BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q02750 (393 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 5KKR-C nrPDB 809 0.0 3EQC-A nrPDB 737 0.0 1S9I-A nrPDB 589 e-169 4AN9-A nrPDB 577 e-165 3VN9-A nrPDB 224 4e-59 3FME-A nrPDB 221 5e-58 3ALO-A nrPDB 208 3e-54 5B2L-A nrPDB 207 4e-54 6AO5-A nrPDB 181 4e-46 4LG4-A nrPDB 181 6e-46 3COM-A nrPDB 174 6e-44 4QMW-A nrPDB 155 2e-38 2XIK-A nrPDB 155 3e-38 4FZF-B nrPDB 152 3e-37 6HXF-B nrPDB 147 7e-36 5J5T-A nrPDB 135 2e-32 5D7A-A nrPDB 133 1e-31 2UV2-A nrPDB 133 2e-31 6CQF-A nrPDB 132 4e-31 3DAK-A nrPDB 125 3e-29 2WQN-A nrPDB 122 2e-28 5DBX-A nrPDB 118 5e-27 4AGU-A nrPDB 116 2e-26 2Z7Q-A nrPDB 115 5e-26 4KRC-A nrPDB 114 6e-26 4U41-A nrPDB 114 7e-26 3Q53-A nrPDB 113 1e-25 4KS7-A nrPDB 113 1e-25 6FD3-A nrPDB 113 2e-25 4UZD-A nrPDB 111 6e-25 3D2K-A nrPDB 110 1e-24 5D9K-A nrPDB 109 2e-24 4XBR-A nrPDB 108 4e-24 4FIE-A nrPDB 108 4e-24 2Q0N-A nrPDB 108 6e-24 4B8L-A nrPDB 108 6e-24 4JDH-A nrPDB 108 6e-24 2BPM-A nrPDB 107 6e-24 3ZDU-A nrPDB 107 8e-24 6ED6-A nrPDB 107 1e-23 2XNP-A nrPDB 106 1e-23 5X3F-B nrPDB 105 3e-23 5G6V-A nrPDB 105 3e-23 2F57-A nrPDB 105 4e-23 1U5R-A nrPDB 105 5e-23 1FOT-A nrPDB 103 1e-22 2GCD-A nrPDB 103 1e-22 6E9W-A nrPDB 103 2e-22 6E2O-A nrPDB 102 2e-22 1UA2-A nrPDB 101 5e-22 5DYK-A nrPDB 100 1e-21 3A8W-A nrPDB 100 1e-21 4WB7-A nrPDB 100 1e-21 2F9G-A nrPDB 100 1e-21 6GU6-A nrPDB 100 1e-21 5WAX-A nrPDB 100 2e-21 4BGQ-A nrPDB 100 2e-21 2JDO-A nrPDB 100 2e-21 5KCV-A nrPDB 100 2e-21 3MV5-A nrPDB 100 2e-21 5N23-A nrPDB 99 2e-21 4L42-A nrPDB 99 4e-21 4RLP-A nrPDB 99 4e-21 4FR4-A nrPDB 99 4e-21 5F9E-A nrPDB 99 4e-21 3NIZ-A nrPDB 98 5e-21 1V0B-A nrPDB 98 7e-21 5FET-A nrPDB 97 8e-21 4I6B-A nrPDB 97 1e-20 5LOH-A nrPDB 96 2e-20 4AF3-A nrPDB 96 3e-20 5ES1-A nrPDB 96 3e-20 4AW2-A nrPDB 96 3e-20 4YNZ-A nrPDB 96 4e-20 3PPZ-A nrPDB 95 5e-20 6C9D-A nrPDB 95 6e-20 4BBM-A nrPDB 95 7e-20 2QNJ-A nrPDB 95 7e-20 2HAK-A nrPDB 95 7e-20 6BDL-A nrPDB 94 1e-19 4AU8-A nrPDB 94 1e-19 3ORZ-A nrPDB 93 2e-19 3HDN-A nrPDB 93 2e-19 3OHT-A nrPDB 92 3e-19 3UC3-A nrPDB 92 4e-19 4IDT-A nrPDB 92 4e-19 4JXF-A nrPDB 92 4e-19 3MN3-A nrPDB 92 5e-19 4REW-A nrPDB 91 6e-19 4GS6-A nrPDB 91 6e-19 4CFH-A nrPDB 91 6e-19 3ZUT-A nrPDB 91 7e-19 4RED-A nrPDB 91 7e-19 5KZ7-A nrPDB 91 8e-19 1G3N-A nrPDB 91 9e-19 3UDB-A nrPDB 91 1e-18 4EWQ-A nrPDB 90 1e-18 3TXO-A nrPDB 90 2e-18 4UY9-A nrPDB 90 2e-18 4G3E-A nrPDB 89 2e-18 4WNO-A nrPDB 89 2e-18 3NCG-A nrPDB 89 2e-18 4OTD-A nrPDB 89 3e-18 4C0T-A nrPDB 89 3e-18 4CFF-A nrPDB 89 4e-18 1VZO-A nrPDB 89 4e-18 3DFA-A nrPDB 89 5e-18 3TKU-A nrPDB 88 5e-18 4NEU-A nrPDB 88 7e-18 6CTH-A nrPDB 88 7e-18 4TPT-A nrPDB 88 8e-18 3H4J-B nrPDB 87 9e-18 4HVI-A nrPDB 87 9e-18 5EZV-A nrPDB 87 9e-18 5O2C-A nrPDB 87 1e-17 6QAU-A nrPDB 87 1e-17 3SXS-A nrPDB 87 1e-17 5JN2-A nrPDB 87 1e-17 3E3P-A nrPDB 87 1e-17 2PMN-X nrPDB 87 2e-17 3MA6-A nrPDB 87 2e-17 5UUU-A nrPDB 87 2e-17 3PVW-A nrPDB 87 2e-17 2A1A-B nrPDB 87 2e-17 5VO2-A nrPDB 86 2e-17 3UTO-A nrPDB 86 3e-17 1KOA-A nrPDB 86 3e-17 4D28-A nrPDB 86 4e-17 5O2B-A nrPDB 86 4e-17 3DTC-A nrPDB 85 4e-17 3DB8-A nrPDB 85 4e-17 4APC-A nrPDB 85 5e-17 5LPZ-A nrPDB 85 6e-17 5LPV-A nrPDB 85 6e-17 2I0E-A nrPDB 85 6e-17 3DXN-A nrPDB 85 6e-17 3PFQ-A nrPDB 85 6e-17 4E93-A nrPDB 85 6e-17 3KK8-A nrPDB 85 6e-17 3HZT-A nrPDB 85 6e-17 3PP0-A nrPDB 85 7e-17 2YZA-A nrPDB 85 7e-17 2BDW-A nrPDB 84 7e-17 4UYA-A nrPDB 84 9e-17 5XZW-A nrPDB 84 1e-16 3IS5-A nrPDB 84 1e-16 3UIU-A nrPDB 84 1e-16 2W96-B nrPDB 84 1e-16 3LIJ-A nrPDB 84 2e-16 6J5U-C nrPDB 83 2e-16 2W4O-A nrPDB 83 2e-16 3QA8-A nrPDB 82 3e-16 4M7I-A nrPDB 82 3e-16 2X4F-A nrPDB 82 3e-16 4RA4-A nrPDB 82 4e-16 5HVK-A nrPDB 82 4e-16 1U59-A nrPDB 82 4e-16 2VD5-A nrPDB 82 4e-16 4KIK-B nrPDB 82 5e-16 2OU7-A nrPDB 82 5e-16 2YAB-A nrPDB 82 5e-16 6BXI-A nrPDB 82 5e-16 4J52-A nrPDB 82 6e-16 2OZO-A nrPDB 81 7e-16 3ORP-A nrPDB 81 8e-16 6CMJ-A nrPDB 81 8e-16 4PDS-A nrPDB 81 8e-16 1KOB-A nrPDB 81 9e-16 6FDY-U nrPDB 81 9e-16 4QNY-A nrPDB 81 9e-16 5AMN-A nrPDB 81 1e-15 4Y93-A nrPDB 81 1e-15 2J90-A nrPDB 81 1e-15 4YFF-A nrPDB 80 1e-15 4Y83-A nrPDB 80 1e-15 4E7W-A nrPDB 80 1e-15 3NYO-A nrPDB 80 2e-15 5AIR-A nrPDB 80 2e-15 4IC8-A nrPDB 80 2e-15 5TOS-A nrPDB 80 2e-15 2W1I-A nrPDB 80 2e-15 5UIU-A nrPDB 80 2e-15 3TAC-A nrPDB 79 2e-15 5IG1-A nrPDB 79 3e-15 2H34-A nrPDB 79 3e-15 3GUB-A nrPDB 79 3e-15 5O0Y-A nrPDB 79 3e-15 4XI2-A nrPDB 79 3e-15 5YKS-A nrPDB 79 3e-15 4PWN-A nrPDB 79 4e-15 3C51-A nrPDB 79 4e-15 4ZSG-A nrPDB 79 4e-15 6DTL-A nrPDB 79 4e-15 5J0A-A nrPDB 79 4e-15 4EQM-A nrPDB 79 4e-15 6E4F-A nrPDB 79 4e-15 4CZT-A nrPDB 79 4e-15 3IO7-A nrPDB 79 4e-15 2WTK-B nrPDB 79 4e-15 3GC9-A nrPDB 79 5e-15 5YV8-A nrPDB 78 5e-15 4B6L-A nrPDB 78 6e-15 3QGY-A nrPDB 78 7e-15 5GNK-A nrPDB 78 8e-15 3MIA-A nrPDB 78 8e-15 6NPU-A nrPDB 77 1e-14 1ZWS-A nrPDB 77 1e-14 5X5O-A nrPDB 77 1e-14 4MVF-A nrPDB 77 1e-14 2A27-A nrPDB 77 1e-14 2XYN-A nrPDB 77 1e-14 4CRS-A nrPDB 77 1e-14 4TNB-A nrPDB 77 2e-14 5TQX-A nrPDB 77 2e-14 4XEY-B nrPDB 77 2e-14 2BRG-A nrPDB 77 2e-14 1CM8-A nrPDB 77 2e-14 4FG9-A nrPDB 76 2e-14 5EFQ-A nrPDB 76 2e-14 2PL0-A nrPDB 76 2e-14 2DQ7-X nrPDB 76 2e-14 4CSV-A nrPDB 76 3e-14 5FM2-A nrPDB 76 3e-14 3LZB-A nrPDB 76 3e-14 4RGJ-A nrPDB 75 4e-14 2FO0-A nrPDB 75 4e-14 2VN9-A nrPDB 75 5e-14 3LM0-A nrPDB 75 6e-14 3BBT-B nrPDB 75 6e-14 5VD3-A nrPDB 74 8e-14 4JG6-A nrPDB 74 9e-14 6DBN-A nrPDB 74 1e-13 5H2U-A nrPDB 74 1e-13 5Z33-A nrPDB 74 1e-13 4IAN-A nrPDB 74 1e-13 3Q5I-A nrPDB 74 1e-13 3E7O-A nrPDB 74 1e-13 3OZ6-A nrPDB 74 1e-13 2V7O-A nrPDB 74 1e-13 6F3F-A nrPDB 73 2e-13 4YZB-A nrPDB 73 2e-13 4YHJ-A nrPDB 73 2e-13 2Y7J-A nrPDB 73 2e-13 1PHK-A nrPDB 73 2e-13 5XD6-A nrPDB 73 2e-13 2JAM-A nrPDB 73 2e-13 3KN6-A nrPDB 73 3e-13 3A4O-X nrPDB 73 3e-13 5AWM-A nrPDB 72 3e-13 2XS0-A nrPDB 72 3e-13 5FG8-A nrPDB 72 4e-13 4D2V-A nrPDB 72 5e-13 2H8H-A nrPDB 72 5e-13 4LRM-A nrPDB 72 6e-13 4O2Z-A nrPDB 71 6e-13 4NST-A nrPDB 71 8e-13 4JLC-A nrPDB 71 8e-13 6CCF-A nrPDB 71 9e-13 5C26-A nrPDB 71 1e-12 2HW6-A nrPDB 71 1e-12 5SYS-A nrPDB 71 1e-12 4QTB-A nrPDB 70 1e-12 3FXW-A nrPDB 70 1e-12 5JZN-A nrPDB 70 1e-12 4CQG-A nrPDB 70 1e-12 3GC0-A nrPDB 70 2e-12 4FL3-A nrPDB 70 2e-12 4OLI-A nrPDB 70 2e-12 2WO6-A nrPDB 70 2e-12 6NT9-A nrPDB 70 2e-12 3DLS-A nrPDB 70 2e-12 4MYG-A nrPDB 70 2e-12 2YCR-A nrPDB 70 2e-12 4OW8-A nrPDB 69 2e-12 1JNK-A nrPDB 69 2e-12 3EB0-A nrPDB 69 2e-12 4EUU-A nrPDB 69 3e-12 4E20-A nrPDB 69 3e-12 4X3F-A nrPDB 69 3e-12 5X8I-B nrPDB 69 3e-12 1U54-B nrPDB 69 3e-12 4EUT-A nrPDB 69 3e-12 4HZS-A nrPDB 69 4e-12 3FI2-A nrPDB 69 4e-12 5NGU-A nrPDB 69 4e-12 3I6U-A nrPDB 69 4e-12 3F3Z-A nrPDB 68 5e-12 6O8B-A nrPDB 68 5e-12 6DBM-A nrPDB 68 6e-12 6B2Q-A nrPDB 68 6e-12 4P5Q-A nrPDB 68 6e-12 1ZXE-A nrPDB 68 6e-12 5MJB-A nrPDB 68 7e-12 2HK5-A nrPDB 68 7e-12 1JPA-A nrPDB 68 7e-12 5WNL-A nrPDB 68 8e-12 3N9X-A nrPDB 67 9e-12 1K9A-A nrPDB 67 1e-11 2JC6-A nrPDB 67 1e-11 4LQP-A nrPDB 67 1e-11 1BYG-A nrPDB 67 1e-11 1LUF-A nrPDB 67 1e-11 6GQK-A nrPDB 67 1e-11 3LMG-A nrPDB 67 2e-11 3DKO-A nrPDB 66 2e-11 6FYV-A nrPDB 66 2e-11 5TUR-A nrPDB 66 2e-11 2R2P-A nrPDB 66 2e-11 2Y6O-A nrPDB 66 2e-11 5ZTN-A nrPDB 66 3e-11 3BGP-A nrPDB 66 3e-11 5AR8-A nrPDB 66 3e-11 3V5Q-A nrPDB 66 3e-11 4M69-B nrPDB 66 3e-11 4RC3-A nrPDB 66 3e-11 4BTF-A nrPDB 66 3e-11 5E8V-A nrPDB 65 4e-11 4XCU-A nrPDB 65 4e-11 3NIE-A nrPDB 65 4e-11 2VWV-A nrPDB 65 5e-11 5A46-A nrPDB 65 5e-11 3BEA-A nrPDB 65 5e-11 6FER-A nrPDB 65 5e-11 3GQL-A nrPDB 65 6e-11 2PSQ-A nrPDB 65 6e-11 4AT3-A nrPDB 65 6e-11 3TT0-A nrPDB 65 6e-11 1FVR-A nrPDB 64 8e-11 6FEX-A nrPDB 64 1e-10 5L6P-A nrPDB 64 1e-10 5Y86-A nrPDB 64 1e-10 3C1X-A nrPDB 64 1e-10 1NY3-A nrPDB 63 2e-10 5HLW-A nrPDB 63 2e-10 2OZA-A nrPDB 63 2e-10 2VZ6-A nrPDB 63 2e-10 3KA0-A nrPDB 63 2e-10 5U6Y-A nrPDB 63 2e-10 2QKW-B nrPDB 63 2e-10 4NIF-A nrPDB 63 2e-10 5M07-A nrPDB 63 3e-10 5EG3-A nrPDB 63 3e-10 4EBW-A nrPDB 63 3e-10 5KMM-A nrPDB 63 3e-10 4XUF-A nrPDB 62 3e-10 2OGV-A nrPDB 62 3e-10 1AD5-A nrPDB 62 3e-10 3CJF-A nrPDB 62 3e-10 5X02-A nrPDB 62 3e-10 3BHH-A nrPDB 62 3e-10 4M66-A nrPDB 62 3e-10 4R7H-A nrPDB 62 4e-10 3PLS-A nrPDB 62 5e-10 5UNP-A nrPDB 62 5e-10 4F0G-A nrPDB 62 6e-10 6BSD-A nrPDB 62 6e-10 6GVJ-A nrPDB 61 7e-10 5HI2-A nrPDB 61 7e-10 3G0E-A nrPDB 61 7e-10 4PDO-A nrPDB 61 8e-10 3KRL-A nrPDB 61 9e-10 3VHK-A nrPDB 61 1e-09 2J0K-A nrPDB 60 1e-09 4RT7-A nrPDB 60 1e-09 3KUL-B nrPDB 60 1e-09 6CKI-A nrPDB 60 1e-09 3OMV-A nrPDB 60 1e-09 3SOA-A nrPDB 60 1e-09 3HMP-A nrPDB 60 2e-09 3I81-A nrPDB 60 2e-09 4H1J-A nrPDB 60 2e-09 4X7Q-B nrPDB 60 2e-09 3LLT-A nrPDB 59 3e-09 2WTK-C nrPDB 59 3e-09 2JD5-A nrPDB 59 3e-09 4K33-A nrPDB 59 3e-09 3QD2-B nrPDB 59 3e-09 4CRL-A nrPDB 59 5e-09 5HIE-A nrPDB 59 5e-09 5AP3-A nrPDB 59 5e-09 3ZBF-A nrPDB 58 6e-09 3HNG-A nrPDB 58 8e-09 2ZMD-A nrPDB 57 1e-08 3UIM-A nrPDB 57 1e-08 5U6B-A nrPDB 57 1e-08 4XLV-A nrPDB 57 1e-08 3PG1-A nrPDB 57 1e-08 3HKO-A nrPDB 56 3e-08 3ZZW-A nrPDB 55 4e-08 3MDY-A nrPDB 55 5e-08 5GRN-A nrPDB 55 8e-08 1PY5-A nrPDB 54 8e-08 3M42-A nrPDB 54 1e-07 2I6L-A nrPDB 54 1e-07 3RP9-A nrPDB 54 2e-07 6BFN-A nrPDB 53 2e-07 5VDK-A nrPDB 53 2e-07 5VC6-A nrPDB 53 2e-07 3SOC-A nrPDB 52 3e-07 3Q4U-A nrPDB 52 4e-07 2QLU-A nrPDB 52 5e-07 3AOX-A nrPDB 51 8e-07 3G2F-A nrPDB 51 1e-06 5WNO-A nrPDB 51 1e-06 3MY0-A nrPDB 51 1e-06 1TKI-A nrPDB 51 1e-06 5IKW-A nrPDB 50 1e-06 5L2Q-C nrPDB 50 1e-06 5TE0-A nrPDB 50 1e-06 4C59-A nrPDB 50 2e-06 2X7G-A nrPDB 50 2e-06 4WUA-A nrPDB 50 2e-06 4LFI-A nrPDB 50 2e-06 6O6Q-A nrPDB 49 4e-06 4JRN-A nrPDB 49 4e-06 3QUP-A nrPDB 49 4e-06 6HMD-A nrPDB 49 4e-06 5XVU-A nrPDB 49 4e-06 5X18-A nrPDB 48 7e-06 4L68-A nrPDB 48 9e-06 5U6C-A nrPDB 47 1e-05 4BTK-A nrPDB 47 1e-05 4NFN-A nrPDB 47 1e-05 3RAW-A nrPDB 47 2e-05 6EII-A nrPDB 47 2e-05 4MD7-E nrPDB 46 2e-05 2PVN-A nrPDB 45 4e-05 2CMW-A nrPDB 44 1e-04 4L00-A nrPDB 44 1e-04 4F9B-A nrPDB 44 1e-04 2RIO-A nrPDB 44 1e-04 4XHH-A nrPDB 44 2e-04 2BUJ-A nrPDB 44 2e-04 2C47-A nrPDB 43 2e-04 4NT4-A nrPDB 43 2e-04 4XHL-A nrPDB 43 3e-04 5CLR-A nrPDB 42 4e-04 6J6I-B nrPDB 42 5e-04 2CHL-A nrPDB 41 8e-04 4AZV-A nrPDB 41 0.001 6DC0-A nrPDB 40 0.001 5CEK-A nrPDB 40 0.002 4AZW-A nrPDB 40 0.002 5USZ-A nrPDB 40 0.002 6HV0-A nrPDB 39 0.003 4PL5-B nrPDB 39 0.003 4TN6-A nrPDB 38 0.006 5UV4-A nrPDB 38 0.006 1CSN-A nrPDB 38 0.007 2LAV-A nrPDB 38 0.007 2RSV-A nrPDB 38 0.009 3SV0-A nrPDB 37 0.020 5FQD-C nrPDB 33 0.20 6EQI-C nrPDB 32 0.35 4OAU-C nrPDB 32 0.36 4O1O-A nrPDB 31 0.74 6BME-A nrPDB 30 1.6 4IX6-A nrPDB 30 1.9 3RC8-A nrPDB 30 2.1 5X1R-A nrPDB 29 3.5 2JII-A nrPDB 28 5.4 1XOC-A nrPDB 28 6.0 4DA1-A nrPDB 28 7.7 2IQ1-A nrPDB 28 8.4 2ZSG-A nrPDB 28 9.6 >5KKR-C nrPDB Length = 395 Score = 809 bits (2090), Expect = 0.0, Method: Compositional matrix adjust. Identities = 392/393 (99%), Positives = 392/393 (99%) Query: 1 MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV 60 MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV Sbjct: 3 MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV 62 Query: 61 GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE 120 GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE Sbjct: 63 GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE 122 Query: 121 CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL 180 CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL Sbjct: 123 CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL 182 Query: 181 REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY 240 REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY Sbjct: 183 REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY 242 Query: 241 SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY 300 SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY Sbjct: 243 SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY 302 Query: 301 GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF 360 GMDSRPPMAIFELLDYIVNEPPPKLPS VFSLEFQDFVNKCLIKNPAERADLKQLMVHAF Sbjct: 303 GMDSRPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF 362 Query: 361 IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV 393 IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV Sbjct: 363 IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV 395 >3EQC-A nrPDB Length = 360 Score = 737 bits (1902), Expect = 0.0, Method: Compositional matrix adjust. Identities = 356/359 (99%), Positives = 358/359 (99%) Query: 35 KKLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVM 94 KKLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVM Sbjct: 2 KKLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVM 61 Query: 95 ARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQV 154 ARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQV Sbjct: 62 ARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQV 121 Query: 155 LKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQ 214 LKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQ Sbjct: 122 LKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQ 181 Query: 215 LIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELM 274 LIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELM Sbjct: 182 LIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELM 241 Query: 275 FGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEF 334 FGCQVEGDAAETPPRPRTPGRPL+ +GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEF Sbjct: 242 FGCQVEGDAAETPPRPRTPGRPLNKFGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEF 301 Query: 335 QDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV 393 QDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV Sbjct: 302 QDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV 360 >1S9I-A nrPDB Length = 354 Score = 589 bits (1518), Expect = e-169, Method: Compositional matrix adjust. Identities = 294/345 (85%), Positives = 314/345 (91%), Gaps = 4/345 (1%) Query: 51 EAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQ 110 EAFLTQK KVGELKDDDFE+ISELGAGNGGVV KV H+PSGL+MARKLIHLEIKPAIRNQ Sbjct: 1 EAFLTQKAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQ 60 Query: 111 IIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVS 170 IIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLK+A RIPE+ILGKVS Sbjct: 61 IIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVS 120 Query: 171 IAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYM 230 IAV++GL YLREKH+IMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYM Sbjct: 121 IAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYM 180 Query: 231 SPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQV----EGDAAET 286 +PERLQGTHYSVQSDIWSMGLSLVE+AVGRYPIPPPDAKELE +FG V EG+ Sbjct: 181 APERLQGTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSI 240 Query: 287 PPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNP 346 PRPR PGRP+S +GMDSRP MAIFELLDYIVNEPPPKLP+GVF+ +FQ+FVNKCLIKNP Sbjct: 241 SPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNP 300 Query: 347 AERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHAA 391 AERADLK L H FIKRS+ EEVDFAGWLC T+ LNQP TPT A Sbjct: 301 AERADLKMLTNHTFIKRSEVEEVDFAGWLCKTLRLNQPGTPTRTA 345 >4AN9-A nrPDB Length = 301 Score = 577 bits (1488), Expect = e-165, Method: Compositional matrix adjust. Identities = 287/333 (86%), Positives = 288/333 (86%), Gaps = 42/333 (12%) Query: 60 VGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLH 119 +GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLH Sbjct: 3 LGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLH 62 Query: 120 ECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTY 179 ECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTY Sbjct: 63 ECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTY 122 Query: 180 LREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTH 239 LREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID MAN FVGTRSYMSPERLQGTH Sbjct: 123 LREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDEMANEFVGTRSYMSPERLQGTH 182 Query: 240 YSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSS 299 YSVQSDIWSMGLSLVEMAVGRYP Sbjct: 183 YSVQSDIWSMGLSLVEMAVGRYP------------------------------------- 205 Query: 300 YGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHA 359 RPPMAIFELLDYIVNEPPPKLPS VFSLEFQDFVNKCLIKNPAERADLKQLMVHA Sbjct: 206 -----RPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFVNKCLIKNPAERADLKQLMVHA 260 Query: 360 FIKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAG 392 FIKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAG Sbjct: 261 FIKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAG 293 >3VN9-A nrPDB Length = 340 Score = 224 bits (572), Expect = 4e-59, Method: Compositional matrix adjust. Identities = 125/329 (37%), Positives = 187/329 (56%), Gaps = 52/329 (15%) Query: 62 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQV-LHE 120 E+K DD E I ELG G GVV K+ H PSG +MA K I + + +++ +L + + Sbjct: 47 EVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRT 106 Query: 121 CNSPYIVGFYGAFYSDGEISICMEHMDGGSLD----QVLKKAGRIPEQILGKVSIAVIKG 176 + P+ V FYGA + +G++ ICME MD SLD QV+ K IPE ILGK++++++K Sbjct: 107 VDCPFTVTFYGALFREGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVKA 165 Query: 177 LTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSF-VGTRSYMSPER- 234 L +L K ++HRDVKPSN+L+N+ G++K+CDFG+SG L+DS+A + G + YM+PER Sbjct: 166 LEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERI 225 Query: 235 ---LQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPR 291 L YSV+SDIWS+G++++E+A+ R+P D+ TP Sbjct: 226 NPELNQKGYSVKSDIWSLGITMIELAILRFPY------------------DSWGTP---- 263 Query: 292 TPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERAD 351 F+ L +V EP P+LP+ FS EF DF ++CL KN ER Sbjct: 264 -------------------FQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPT 304 Query: 352 LKQLMVHAFIKRSDAEEVDFAGWLCSTIG 380 +LM H F +++ D A ++ +G Sbjct: 305 YPELMQHPFFTLHESKGTDVASFVKLILG 333 >3FME-A nrPDB Length = 290 Score = 221 bits (563), Expect = 5e-58, Method: Compositional matrix adjust. Identities = 124/329 (37%), Positives = 185/329 (56%), Gaps = 52/329 (15%) Query: 62 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQV-LHE 120 E+K DD E I ELG G GVV K+ H PSG +MA K I + + +++ +L + + Sbjct: 3 EVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRT 62 Query: 121 CNSPYIVGFYGAFYSDGEISICMEHMDGGSLD----QVLKKAGRIPEQILGKVSIAVIKG 176 + P+ V FYGA + +G++ ICME MD SLD QV+ K IPE ILGK++++++K Sbjct: 63 VDCPFTVTFYGALFREGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVKA 121 Query: 177 LTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSF-VGTRSYMSPER- 234 L +L K ++HRDVKPSN+L+N+ G++K+CDFG+SG L+D +A G + YM+PER Sbjct: 122 LEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDDVAKDIDAGCKPYMAPERI 181 Query: 235 ---LQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPR 291 L YSV+SDIWS+G++++E+A+ R+P D+ TP Sbjct: 182 NPELNQKGYSVKSDIWSLGITMIELAILRFPY------------------DSWGTP---- 219 Query: 292 TPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERAD 351 F+ L +V EP P+LP+ FS EF DF ++CL KN ER Sbjct: 220 -------------------FQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPT 260 Query: 352 LKQLMVHAFIKRSDAEEVDFAGWLCSTIG 380 +LM H F +++ D A ++ +G Sbjct: 261 YPELMQHPFFTLHESKGTDVASFVKLILG 289 >3ALO-A nrPDB Length = 327 Score = 208 bits (530), Expect = 3e-54, Method: Compositional matrix adjust. Identities = 122/337 (36%), Positives = 184/337 (54%), Gaps = 57/337 (16%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQV-LHECNSP 124 +D + + E+G G G V K+ HKPSG +MA K I + + Q++ +L V + + P Sbjct: 22 EDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCP 81 Query: 125 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR-----IPEQILGKVSIAVIKGLTY 179 YIV FYGA + +G+ ICME M S D+ K IPE+ILGK+++A +K L + Sbjct: 82 YIVQFYGALFREGDCWICMELM-STSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNH 140 Query: 180 LREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSF-VGTRSYMSPERLQGT 238 L+E KI+HRD+KPSNIL++ G IKLCDFG+SGQL+DS+A + G R YM+PER+ + Sbjct: 141 LKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPS 200 Query: 239 H----YSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPG 294 Y V+SD+WS+G++L E+A GR+P P + Sbjct: 201 ASRQGYDVRSDVWSLGITLYELATGRFPYPKWN--------------------------- 233 Query: 295 RPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSG---VFSLEFQDFVNKCLIKNPAERAD 351 ++F+ L +V PP+L + FS F +FVN CL K+ ++R Sbjct: 234 --------------SVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPK 279 Query: 352 LKQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQPSTPT 388 K+L+ H FI + V+ A ++C + P+TP+ Sbjct: 280 YKELLKHPFILMYEERAVEVACYVCKILD-QMPATPS 315 >5B2L-A nrPDB Length = 324 Score = 207 bits (528), Expect = 4e-54, Method: Compositional matrix adjust. Identities = 121/337 (35%), Positives = 191/337 (56%), Gaps = 55/337 (16%) Query: 50 LEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRN 109 + +LT + + + +D E + E+G+G G V+K+ + +G V+A K + Sbjct: 1 MTGYLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENK 60 Query: 110 QIIRELQVL---HECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKA-GRIPEQI 165 +I+ +L V+ H+C PYIV +G F ++ ++ I ME M G S +++ K+ G IPE+I Sbjct: 61 RILMDLDVVLKSHDC--PYIVQCFGTFITNTDVFIAMELM-GTSAEKLKKRMQGPIPERI 117 Query: 166 LGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANS-FV 224 LGK+++A++K L YL+EKH ++HRDVKPSNIL++ RG+IKLCDFG+SG+L+DS A + Sbjct: 118 LGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSA 177 Query: 225 GTRSYMSPERLQ-----GTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQV 279 G +YM+PER+ Y +++D+WS+G+SLVE+A G++P C+ Sbjct: 178 GCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYK-----------NCKT 226 Query: 280 EGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGV-FSLEFQDFV 338 + FE+L ++ E PP LP + FS +FQ FV Sbjct: 227 D------------------------------FEVLTKVLQEEPPLLPGHMGFSGDFQSFV 256 Query: 339 NKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWL 375 CL K+ +R +L+ H+FIKR + EVD A W Sbjct: 257 KDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWF 293 >6AO5-A nrPDB Length = 362 Score = 181 bits (460), Expect = 4e-46, Method: Compositional matrix adjust. Identities = 107/301 (35%), Positives = 166/301 (55%), Gaps = 50/301 (16%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIV 127 F+ + +LG G+ G VFK HK SG V+A K + +E + +II+E+ ++ +C+SPY+V Sbjct: 12 FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVE---SDLQEIIKEISIMQQCDSPYVV 68 Query: 128 GFYGAFYSDGEISICMEHMDGGSLDQVLK-KAGRIPEQILGKVSIAVIKGLTYLREKHKI 186 +YG+++ + ++ I ME+ GS+ +++ + + E + + + +KGL YL KI Sbjct: 69 KYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRKI 128 Query: 187 MHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA--NSFVGTRSYMSPERLQGTHYSVQS 244 HR++K NIL+N+ G KL DFGV+GQL D+MA N+ +GT +M+PE +Q Y+ + Sbjct: 129 -HRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVA 187 Query: 245 DIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDS 304 DIWS+G++ +EMA G+ PP A D Sbjct: 188 DIWSLGITSIEMAEGK----PPYA----------------------------------DI 209 Query: 305 RPPMAIFELLDYIVNEPPPKLPS-GVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKR 363 P AIF I PPP ++S +F DFV KCL+KNP +RA QL+ H FIK Sbjct: 210 HPMRAIF----MIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKN 265 Query: 364 S 364 + Sbjct: 266 A 266 >4LG4-A nrPDB Length = 299 Score = 181 bits (458), Expect = 6e-46, Method: Compositional matrix adjust. Identities = 107/301 (35%), Positives = 166/301 (55%), Gaps = 50/301 (16%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIV 127 F+ + +LG G+ G VFK HK SG V+A K + +E + +II+E+ ++ +C+SPY+V Sbjct: 13 FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVE---SDLQEIIKEISIMQQCDSPYVV 69 Query: 128 GFYGAFYSDGEISICMEHMDGGSLDQVLK-KAGRIPEQILGKVSIAVIKGLTYLREKHKI 186 +YG+++ + ++ I ME+ GS+ +++ + + E + + + +KGL YL KI Sbjct: 70 KYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRKI 129 Query: 187 MHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA--NSFVGTRSYMSPERLQGTHYSVQS 244 HR++K NIL+N+ G KL DFGV+GQL D+MA N+ +GT +M+PE +Q Y+ + Sbjct: 130 -HRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVA 188 Query: 245 DIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDS 304 DIWS+G++ +EMA G+ PP A D Sbjct: 189 DIWSLGITSIEMAEGK----PPYA----------------------------------DI 210 Query: 305 RPPMAIFELLDYIVNEPPPKLPS-GVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKR 363 P AIF I PPP ++S +F DFV KCL+KNP +RA QL+ H FIK Sbjct: 211 HPMRAIF----MIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKN 266 Query: 364 S 364 + Sbjct: 267 A 267 >3COM-A nrPDB Length = 314 Score = 174 bits (441), Expect = 6e-44, Method: Compositional matrix adjust. Identities = 105/332 (31%), Positives = 180/332 (54%), Gaps = 52/332 (15%) Query: 37 LEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMAR 96 LE ++L R++L+ + + + ++ F+ + +LG G+ G V+K HK +G ++A Sbjct: 2 LETVQLRNPPRRQLKKL--DEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAI 59 Query: 97 KLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLK 156 K + +E + +II+E+ ++ +C+SP++V +YG+++ + ++ I ME+ GS+ +++ Sbjct: 60 KQVPVE---SDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIR 116 Query: 157 -KAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL 215 + + E + + + +KGL YL KI HRD+K NIL+N+ G KL DFGV+GQL Sbjct: 117 LRNKTLTEDEIATILQSTLKGLEYLHFMRKI-HRDIKAGNILLNTEGHAKLADFGVAGQL 175 Query: 216 IDSMA--NSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELEL 273 D+MA N+ +GT +M+PE +Q Y+ +DIWS+G++ +EMA G+ PP A Sbjct: 176 TDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGK----PPYA----- 226 Query: 274 MFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPS-GVFSL 332 D P AIF I PPP ++S Sbjct: 227 -----------------------------DIHPMRAIF----MIPTNPPPTFRKPELWSD 253 Query: 333 EFQDFVNKCLIKNPAERADLKQLMVHAFIKRS 364 F DFV +CL+K+P +RA QL+ H F++ + Sbjct: 254 NFTDFVKQCLVKSPEQRATATQLLQHPFVRSA 285 >4QMW-A nrPDB Length = 310 Score = 155 bits (393), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 102/299 (34%), Positives = 159/299 (53%), Gaps = 47/299 (15%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIV 127 F K+ ++G G+ G VFK + V+A K+I LE I +E+ VL +C+SPY+ Sbjct: 31 FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVT 90 Query: 128 GFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIM 187 +YG++ D ++ I ME++ GGS +L + G + E + + ++KGL YL + KI Sbjct: 91 KYYGSYLKDTKLWIIMEYLGGGSALDLL-EPGPLDETQIATILREILKGLDYLHSEKKI- 148 Query: 188 HRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA--NSFVGTRSYMSPERLQGTHYSVQSD 245 HRD+K +N+L++ GE+KL DFGV+GQL D+ N+FVGT +M+PE ++ + Y ++D Sbjct: 149 HRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKAD 208 Query: 246 IWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSR 305 IWS+G++ +E+A G PP + EL Sbjct: 209 IWSLGITAIELARGE----PPHS-ELH--------------------------------- 230 Query: 306 PPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRS 364 PM + L I PP L G +S ++FV CL K P+ R K+L+ H FI R+ Sbjct: 231 -PMKVLFL---IPKNNPPTL-EGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRN 284 >2XIK-A nrPDB Length = 294 Score = 155 bits (391), Expect = 3e-38, Method: Compositional matrix adjust. Identities = 103/316 (32%), Positives = 163/316 (51%), Gaps = 49/316 (15%) Query: 50 LEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRN 109 L F Q +V ++ F K+ +G G+ G V+K + V+A K+I LE Sbjct: 5 LRGFANQHSRVDP--EELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIE 62 Query: 110 QIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKV 169 I +E+ VL +C+SPYI ++G++ ++ I ME++ GGS +L K G + E + + Sbjct: 63 DIQQEITVLSQCDSPYITRYFGSYLKSTKLWIIMEYLGGGSALDLL-KPGPLEETYIATI 121 Query: 170 SIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA--NSFVGTR 227 ++KGL YL + KI HRD+K +N+L++ +G++KL DFGV+GQL D+ N+FVGT Sbjct: 122 LREILKGLDYLHSERKI-HRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTP 180 Query: 228 SYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETP 287 +M+PE ++ + Y ++DIWS+G++ +E+A G PP++ Sbjct: 181 FWMAPEVIKQSAYDFKADIWSLGITAIELAKGE----PPNS------------------- 217 Query: 288 PRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPA 347 D P +F I PP L G S F++FV CL K+P Sbjct: 218 ---------------DLHPMRVLF----LIPKNSPPTL-EGQHSKPFKEFVEACLNKDPR 257 Query: 348 ERADLKQLMVHAFIKR 363 R K+L+ H FI R Sbjct: 258 FRPTAKELLKHKFITR 273 >4FZF-B nrPDB Length = 283 Score = 152 bits (384), Expect = 3e-37, Method: Compositional matrix adjust. Identities = 97/299 (32%), Positives = 158/299 (52%), Gaps = 47/299 (15%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIV 127 F K+ +G G+ G VFK + V+A K+I LE I +E+ VL +C+S Y+ Sbjct: 10 FTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSSYVT 69 Query: 128 GFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIM 187 +YG++ ++ I ME++ GGS +L +AG E + + ++KGL YL + KI Sbjct: 70 KYYGSYLKGSKLWIIMEYLGGGSALDLL-RAGPFDEFQIATMLKEILKGLDYLHSEKKI- 127 Query: 188 HRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA--NSFVGTRSYMSPERLQGTHYSVQSD 245 HRD+K +N+L++ +G++KL FGV+GQL D+ N+FVGT +M+PE +Q + Y ++D Sbjct: 128 HRDIKAANVLLSEQGDVKLAAFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKAD 187 Query: 246 IWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSR 305 IWS+G++ +E+A G PP++ D Sbjct: 188 IWSLGITAIELAKGE----PPNS----------------------------------DMH 209 Query: 306 PPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRS 364 P +F I PP L G F+ F++F++ CL K+P+ R K+L+ H FI ++ Sbjct: 210 PMRVLF----LIPKNNPPTL-VGDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKN 263 >6HXF-B nrPDB Length = 302 Score = 147 bits (371), Expect = 7e-36, Method: Compositional matrix adjust. Identities = 95/302 (31%), Positives = 159/302 (52%), Gaps = 51/302 (16%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIV 127 +E + ELG G G V+K +K +G + A K+I + + + + I+ E+++L C+ PYIV Sbjct: 21 WEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIV-EIEILATCDHPYIV 79 Query: 128 GFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR-IPEQILGKVSIAVIKGLTYLREKHKI 186 GA+Y DG++ I +E GG++D ++ + R + E + V +++ L +L K +I Sbjct: 80 KLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSK-RI 138 Query: 187 MHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA--NSFVGTRSYMSP-----ERLQGTH 239 +HRD+K N+L+ G+I+L DFGVS + + ++ +SF+GT +M+P E ++ T Sbjct: 139 IHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTP 198 Query: 240 YSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSS 299 Y ++DIWS+G++L+EMA Q+E PP Sbjct: 199 YDYKADIWSLGITLIEMA--------------------QIE------PPHHEL------- 225 Query: 300 YGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHA 359 PM + LL ++PP L +S+EF+DF+ L KNP R QL+ H Sbjct: 226 ------NPMRV--LLKIAKSDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLEHP 277 Query: 360 FI 361 F+ Sbjct: 278 FV 279 >5J5T-A nrPDB Length = 370 Score = 135 bits (341), Expect = 2e-32, Method: Compositional matrix adjust. Identities = 97/307 (31%), Positives = 153/307 (49%), Gaps = 54/307 (17%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIR-ELQVLHECNSP 124 +DFE I +G+G G V+K + +G + A K+I LE P +++ E+ ++ +C P Sbjct: 4 EDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLE--PGEDFAVVQQEIIMMKDCKHP 61 Query: 125 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKH 184 IV ++G++ ++ ICME GGSL + G + E + VS ++GL YL K Sbjct: 62 NIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSKG 121 Query: 185 KIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA--NSFVGTRSYMSP-----ERLQG 237 K MHRD+K +NIL+ G +KL DFGVS Q+ ++A +F+GT +M+P ER G Sbjct: 122 K-MHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKAFIGTPYWMAPEVAAVERKGG 180 Query: 238 THYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPL 297 Y+ D+W++G++ +E+A + PP MF Sbjct: 181 --YNQLCDLWAVGITAIELA----ELQPP-------MF---------------------- 205 Query: 298 SSYGMDSRPPMAIFELLDYIVNEPPPKLPSGV-FSLEFQDFVNKCLIKNPAERADLKQLM 356 D P A+F + N PPKL + +S F FV L KNP +R ++L+ Sbjct: 206 -----DLHPMRALFLMTK--SNFQPPKLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLL 258 Query: 357 VHAFIKR 363 H F+ + Sbjct: 259 QHPFVTQ 265 >5D7A-A nrPDB Length = 308 Score = 133 bits (334), Expect = 1e-31, Method: Compositional matrix adjust. Identities = 91/311 (29%), Positives = 153/311 (49%), Gaps = 61/311 (19%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE-CNSPYI 126 FE + +G G G V+K H +G + A K+ +++ +I +E+ +L + + I Sbjct: 19 FELVELVGNGTYGQVYKGRHVKTGQLAAIKV--MDVTGDEEEEIKQEINMLKKYSHHRNI 76 Query: 127 VGFYGAFYS------DGEISICMEHMDGGSLDQVLK--KAGRIPEQILGKVSIAVIKGLT 178 +YGAF D ++ + ME GS+ ++K K + E+ + + +++GL+ Sbjct: 77 ATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLS 136 Query: 179 YLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA--NSFVGTRSYMSPERLQ 236 +L + HK++HRD+K N+L+ E+KL DFGVS QL ++ N+F+GT +M+PE + Sbjct: 137 HLHQ-HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIA 195 Query: 237 -----GTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPR 291 Y +SD+WS+G++ +EMA G P+ C Sbjct: 196 CDENPDATYDFKSDLWSLGITAIEMAEGAPPL-------------C-------------- 228 Query: 292 TPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERAD 351 D P A+F I P P+L S +S +FQ F+ CL+KN ++R Sbjct: 229 -----------DMHPMRALF----LIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPA 273 Query: 352 LKQLMVHAFIK 362 +QLM H FI+ Sbjct: 274 TEQLMKHPFIR 284 >2UV2-A nrPDB Length = 325 Score = 133 bits (334), Expect = 2e-31, Method: Compositional matrix adjust. Identities = 95/305 (31%), Positives = 150/305 (49%), Gaps = 51/305 (16%) Query: 65 DDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSP 124 +D +E I ELG G G V+K +K + ++ A K+I + + + + ++ E+ +L C+ P Sbjct: 36 EDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMV-EIDILASCDHP 94 Query: 125 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR-IPEQILGKVSIAVIKGLTYLREK 183 IV AFY + + I +E GG++D V+ + R + E + V + L YL + Sbjct: 95 NIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHD- 153 Query: 184 HKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA--NSFVGTRSYMSPERL-----Q 236 +KI+HRD+K NIL G+IKL DFGVS + ++ +SF+GT +M+PE + + Sbjct: 154 NKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSK 213 Query: 237 GTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRP 296 Y ++D+WS+G++L+EMA I PP EL Sbjct: 214 DRPYDYKADVWSLGITLIEMA----EIEPP-HHELN------------------------ 244 Query: 297 LSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLM 356 PM + LL +EPP +S F+DF+ KCL KN R QL+ Sbjct: 245 ----------PMRV--LLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLL 292 Query: 357 VHAFI 361 H F+ Sbjct: 293 QHPFV 297 >6CQF-A nrPDB Length = 297 Score = 132 bits (331), Expect = 4e-31, Method: Compositional matrix adjust. Identities = 87/306 (28%), Positives = 151/306 (49%), Gaps = 52/306 (16%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPY 125 D ++ + LG G G VFK K SG ++A K++ +E + + + +E+ +L C Sbjct: 16 DHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDV-STLQKEILILKTCRHAN 74 Query: 126 IVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHK 185 IV ++G++ ++ ICME GSL + + G + E + V V++GL YL + K Sbjct: 75 IVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSQKK 134 Query: 186 IMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMAN--SFVGTRSYMSPE----RLQGTH 239 I HRD+K +NIL+N GE++L DFG+S Q+ ++A +F+GT +M+PE L+G Sbjct: 135 I-HRDIKGANILINDAGEVRLADFGISAQIGATLARRLAFIGTPYWMAPEVAAVALKGG- 192 Query: 240 YSVQSDIWSMGLSLVEMAVGRYPIPPP--DAKELELMFGCQVEGDAAETPPRPRTPGRPL 297 Y+ DIWS+G++ +E+A + PP D L ++F + + PPR + G+ Sbjct: 193 YNELCDIWSLGITAIELA----ELQPPLFDVHPLRVLF---LMTKSGYQPPRLKEKGK-- 243 Query: 298 SSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMV 357 +S F +F+ L K+P +R +++ Sbjct: 244 --------------------------------WSAAFHNFIKVTLTKSPKKRPSATKMLS 271 Query: 358 HAFIKR 363 H + + Sbjct: 272 HQLVSQ 277 >3DAK-A nrPDB Length = 290 Score = 125 bits (314), Expect = 3e-29, Method: Compositional matrix adjust. Identities = 87/323 (26%), Positives = 149/323 (46%), Gaps = 67/323 (20%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPY 125 DD+E +G+G VV P +A K I+LE +++++E+Q + +C+ P Sbjct: 10 DDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCHHPN 69 Query: 126 IVGFYGAFYSDGEISICMEHMDGGSLDQVLK--------KAGRIPEQILGKVSIAVIKGL 177 IV +Y +F E+ + M+ + GGS+ ++K K+G + E + + V++GL Sbjct: 70 IVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEGL 129 Query: 178 TYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLI-------DSMANSFVGTRSYM 230 YL + +I HRDVK NIL+ G +++ DFGVS L + + +FVGT +M Sbjct: 130 EYLHKNGQI-HRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWM 188 Query: 231 SPERLQGTH-YSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPR 289 +PE ++ Y ++DIWS G++ +E+A G Sbjct: 189 APEVMEQVRGYDFKADIWSFGITAIELATG------------------------------ 218 Query: 290 PRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGV--------FSLEFQDFVNKC 341 P Y PPM + L + PP L +GV + F+ ++ C Sbjct: 219 ----AAPYHKY-----PPMKVLML---TLQNDPPSLETGVQDKEMLKKYGKSFRKMISLC 266 Query: 342 LIKNPAERADLKQLMVHAFIKRS 364 L K+P +R +L+ H F +++ Sbjct: 267 LQKDPEKRPTAAELLRHKFFQKA 289 >2WQN-A nrPDB Length = 310 Score = 122 bits (306), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 86/309 (27%), Positives = 144/309 (46%), Gaps = 53/309 (17%) Query: 67 DFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE--IKPAIRNQIIRELQVLHECNSP 124 +F ++G G V++ + G+ +A K + + + R I+E+ +L + N P Sbjct: 33 NFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHP 92 Query: 125 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR----IPEQILGKVSIAVIKGLTYL 180 ++ +Y +F D E++I +E D G L +++K + IPE+ + K + + L ++ Sbjct: 93 NVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHM 152 Query: 181 REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS---MANSFVGTRSYMSPERLQG 237 + ++MHRD+KP+N+ + + G +KL D G+ G+ S A+S VGT YMSPER+ Sbjct: 153 HSR-RVMHRDIKPANVFITATGVVKLGDLGL-GRFFSSKTTAAHSLVGTPYYMSPERIHE 210 Query: 238 THYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPL 297 Y+ +SDIWS+G L EMA + P Sbjct: 211 NGYNFKSDIWSLGCLLYEMAALQSPF---------------------------------- 236 Query: 298 SSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMV 357 YG M ++ L I P LPS +S E + VN C+ +P +R D+ V Sbjct: 237 --YG----DKMNLYSLCKKIEQCDYPPLPSDHYSEELRQLVNMCINPDPEKRPDVT--YV 288 Query: 358 HAFIKRSDA 366 + KR A Sbjct: 289 YDVAKRMHA 297 >5DBX-A nrPDB Length = 328 Score = 118 bits (295), Expect = 5e-27, Method: Compositional matrix adjust. Identities = 85/327 (25%), Positives = 148/327 (45%), Gaps = 67/327 (20%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPY 125 D +E +G+G VV KP +A K I+LE +++++E+Q + +C+ P Sbjct: 11 DAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMSQCSHPN 70 Query: 126 IVGFYGAFYSDGEISICMEHMDGGSLDQVLK--------KAGRIPEQILGKVSIAVIKGL 177 +V +Y +F E+ + M+ + GGS+ ++K K G + E I+ + V++GL Sbjct: 71 VVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGL 130 Query: 178 TYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLI-------DSMANSFVGTRSYM 230 YL +I HRD+K NIL+ G +++ DFGVS L + + FVGT +M Sbjct: 131 DYLHRNGQI-HRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKDFVGTPCWM 189 Query: 231 SPERLQGTH-YSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPR 289 +PE ++ Y ++D+WS G++ +E+A G Sbjct: 190 APEVMEQVRGYDFKADMWSFGITAIELATG------------------------------ 219 Query: 290 PRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGV--------FSLEFQDFVNKC 341 P Y PPM + L + PP L +GV + F+ ++ C Sbjct: 220 ----AAPYHKY-----PPMKVLML---TLQNDPPTLETGVEDKEMMKKYGKSFRKLLSLC 267 Query: 342 LIKNPAERADLKQLMVHAFIKRSDAEE 368 L K+P++R +L+ F +++ E Sbjct: 268 LQKDPSKRPTAAELLKCKFFQKAKNRE 294 >4AGU-A nrPDB Length = 311 Score = 116 bits (290), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 82/301 (27%), Positives = 139/301 (46%), Gaps = 18/301 (5%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMA-RKLIHLEIKPAIRNQIIRELQVLHECNSP 124 + +EKI ++G G+ GVVFK ++ +G ++A +K + E P I+ +RE+++L + P Sbjct: 3 EKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKHP 62 Query: 125 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKH 184 +V F + + E+ D L ++ + +PE ++ ++ ++ + + KH Sbjct: 63 NLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFC-HKH 121 Query: 185 KIMHRDVKPSNILVNSRGEIKLCDFGVSGQLI--DSMANSFVGTRSYMSPERLQG-THYS 241 +HRDVKP NIL+ IKLCDFG + L + V TR Y SPE L G T Y Sbjct: 122 NCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYDDEVATRWYRSPELLVGDTQYG 181 Query: 242 VQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYG 301 D+W++G E+ G P+ P + +L + GD + + + S Sbjct: 182 PPVDVWAIGCVFAELLSG-VPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFSGVK 240 Query: 302 MDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFI 361 + M EL ++ P L G CL +P ER +QL+ H + Sbjct: 241 IPDPEDMEPLELKFPNISYPALGLLKG------------CLHMDPTERLTCEQLLHHPYF 288 Query: 362 K 362 + Sbjct: 289 E 289 >2Z7Q-A nrPDB Length = 321 Score = 115 bits (287), Expect = 5e-26, Method: Compositional matrix adjust. Identities = 78/230 (33%), Positives = 122/230 (53%), Gaps = 13/230 (5%) Query: 51 EAFLTQKQKVGELKDD--DFEKISELGAGNGGVVF---KVSHKPSGLVMARKLIH---LE 102 E +T K G K D FE + LG G+ G VF KV+ SG + A K++ L+ Sbjct: 11 EISITHHVKAGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLK 70 Query: 103 IKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIP 162 ++ +R ++ R+ +L + N P++V + AF ++G++ + ++ + GG L L K Sbjct: 71 VRDRVRTKMERD--ILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFT 128 Query: 163 EQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID--SMA 220 E+ + + GL +L I++RD+KP NIL++ G IKL DFG+S + ID A Sbjct: 129 EEDVKFYLAELALGLDHLHSL-GIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKA 187 Query: 221 NSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKE 270 SF GT YM+PE + +S +D WS G+ + EM G P D KE Sbjct: 188 YSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKE 237 >4KRC-A nrPDB Length = 317 Score = 114 bits (286), Expect = 6e-26, Method: Compositional matrix adjust. Identities = 88/309 (28%), Positives = 152/309 (49%), Gaps = 33/309 (10%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIV 127 F+++ +LG G V+K +K +G+ +A K + L+ + + IRE+ ++ E IV Sbjct: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIV 66 Query: 128 GFYGAFYSDGEISICMEHMDGGSLDQVL--KKAGRIPE----QILGKVSIAVIKGLTYLR 181 Y +++ ++++ E MD L + + + G P ++ +++GL + Sbjct: 67 RLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCH 125 Query: 182 EKHKIMHRDVKPSNILVNSRGEIKLCDFGVS---GQLIDSMANSFVGTRSYMSPERLQGT 238 E +KI+HRD+KP N+L+N RG++KL DFG++ G +++ ++ V T Y +P+ L G+ Sbjct: 126 E-NKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVV-TLWYRAPDVLMGS 183 Query: 239 H-YSVQSDIWSMGLSLVEMAVGRYPIPP--PDAKELELMFGCQVEGDAAETPPR---PRT 292 YS DIWS G L EM G+ P+ P D ++L+L+F D TP P Sbjct: 184 RTYSTSIDIWSCGCILAEMITGK-PLFPGTNDEEQLKLIF------DIMGTPNESLWPSV 236 Query: 293 PGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADL 352 P + + RPP + ++L EP DF++ L NP R Sbjct: 237 TKLPKYNPNIQQRPPRDLRQVLQPHTKEP--------LDGNLMDFLHGLLQLNPDMRLSA 288 Query: 353 KQLMVHAFI 361 KQ + H + Sbjct: 289 KQALHHPWF 297 >4U41-A nrPDB Length = 332 Score = 114 bits (285), Expect = 7e-26, Method: Compositional matrix adjust. Identities = 89/311 (28%), Positives = 146/311 (46%), Gaps = 61/311 (19%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE-CNSPYI 126 FE + +G G G V+K H +G + A K+ +++ +I E+ +L + + I Sbjct: 26 FELVEVVGNGTYGQVYKGRHVKTGQLAAIKV--MDVTEDEEEEIKLEINMLKKYSHHRNI 83 Query: 127 VGFYGAFYS------DGEISICMEHMDGGSLDQVLK--KAGRIPEQILGKVSIAVIKGLT 178 +YGAF D ++ + ME GS+ ++K K + E + +S +++GL Sbjct: 84 ATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLA 143 Query: 179 YLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA--NSFVGTRSYMSPERLQ 236 +L H ++HRD+K N+L+ E+KL DFGVS QL ++ N+F+GT +M+PE + Sbjct: 144 HL-HIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIA 202 Query: 237 -----GTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPR 291 Y +SD+WS G++ +EMA G P+ Sbjct: 203 CDENPDATYDYRSDLWSCGITAIEMAEGAPPL---------------------------- 234 Query: 292 TPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERAD 351 D P A+F I PPP+L S +S +F F+ CL+KN +R Sbjct: 235 ----------CDMHPMRALF----LIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPS 280 Query: 352 LKQLMVHAFIK 362 +QL+ H FI+ Sbjct: 281 TEQLLKHPFIR 291 >3Q53-A nrPDB Length = 306 Score = 113 bits (283), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 88/322 (27%), Positives = 152/322 (47%), Gaps = 51/322 (15%) Query: 43 DEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE 102 DE+ ++L + ++ VG+ K + + ++G G G V+ +G +A + ++L+ Sbjct: 3 DEEILEKLRSIVS----VGDPKKK-YTRFEKIGQGASGTVYTAMDVATGQEVAIRQMNLQ 57 Query: 103 IKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIP 162 +P + II E+ V+ E +P IV + ++ E+ + ME++ GGSL V+ + Sbjct: 58 QQPK-KELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDE 116 Query: 163 EQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLI--DSMA 220 QI V ++ L +L ++++HRD+K NIL+ G +KL DFG Q+ S Sbjct: 117 GQI-AAVCRECLQALEFLH-SNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKR 174 Query: 221 NSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVE 280 ++ VGT +M+PE + Y + DIWS+G+ +EM +E Sbjct: 175 STMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEM----------------------IE 212 Query: 281 GDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNK 340 G E P P R L + P + + P KL S F+DF+N+ Sbjct: 213 G---EPPYLNENPLRALYLIATNGTPEL-----------QNPEKL-----SAIFRDFLNR 253 Query: 341 CLIKNPAERADLKQLMVHAFIK 362 CL + +R K+L+ H F+K Sbjct: 254 CLEMDVEKRGSAKELIQHQFLK 275 >4KS7-A nrPDB Length = 292 Score = 113 bits (283), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 87/302 (28%), Positives = 145/302 (48%), Gaps = 51/302 (16%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPY 125 D + KI G G+ G+V K SG +A K++ L K R + E+ ++ + Sbjct: 26 DSYVKI---GEGSTGIVCLAREKHSGRQVAVKMMDLR-KQQRRELLFNEVVIMRDYQHFN 81 Query: 126 IVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHK 185 +V Y ++ E+ + ME + GG+L ++ + R+ E+ + V AV++ L YL + Sbjct: 82 VVEMYKSYLVGEELWVLMEFLQGGALTDIVSQV-RLNEEQIATVCEAVLQALAYLHAQ-G 139 Query: 186 IMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSM--ANSFVGTRSYMSPERLQGTHYSVQ 243 ++HRD+K +IL+ G +KL DFG Q+ + S VGT +M+PE + + Y+ + Sbjct: 140 VIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATE 199 Query: 244 SDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMD 303 DIWS+G+ ++EM G PP Y D Sbjct: 200 VDIWSLGIMVIEMVDGE---PP----------------------------------YFSD 222 Query: 304 SRPPMAIFELLDYIVNEPPPKLP-SGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIK 362 S P A+ L D PPPKL S S +DF+ + L+++P ERA ++L+ H F+ Sbjct: 223 S-PVQAMKRLRD----SPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFLL 277 Query: 363 RS 364 ++ Sbjct: 278 QT 279 >6FD3-A nrPDB Length = 300 Score = 113 bits (282), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 89/322 (27%), Positives = 151/322 (46%), Gaps = 51/322 (15%) Query: 43 DEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE 102 DE+ ++L + ++ VG+ K + + ++G G G V+ +G +A K ++L+ Sbjct: 4 DEEILEKLRSIVS----VGDPKKK-YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQ 58 Query: 103 IKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIP 162 +P + II E+ V+ E +P IV + ++ E+ + ME++ GGSL V+ + Sbjct: 59 QQPK-KELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDE 117 Query: 163 EQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLI--DSMA 220 QI V ++ L +L ++++HRD+K NIL+ G +KL DFG Q+ S Sbjct: 118 GQI-AAVCRECLQALDFLH-SNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKR 175 Query: 221 NSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVE 280 ++ VGT +M+PE + Y + DIWS+G+ +EM VE Sbjct: 176 STMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEM----------------------VE 213 Query: 281 GDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNK 340 G E P P R L + P + + P +L S F+DF+N+ Sbjct: 214 G---EPPYLNENPLRALYLIATNGTPEL-----------QNPERL-----SAVFRDFLNR 254 Query: 341 CLIKNPAERADLKQLMVHAFIK 362 CL + R K+L+ H F+K Sbjct: 255 CLEMDVDRRGSAKELLQHPFLK 276 >4UZD-A nrPDB Length = 287 Score = 111 bits (277), Expect = 6e-25, Method: Compositional matrix adjust. Identities = 64/206 (31%), Positives = 108/206 (52%), Gaps = 8/206 (3%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLI---HLEIKPAIRNQIIRELQVLHECN 122 +DFE LG G G V+ K S ++A K++ LE K + +Q+ RE+++ Sbjct: 8 EDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLE-KAGVEHQLRREVEIQSHLR 66 Query: 123 SPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLRE 182 P I+ YG F+ + + +E+ G++ + L+K + EQ + L+Y Sbjct: 67 HPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHS 126 Query: 183 KHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSV 242 K +++HRD+KP N+L+ S GE+K+ DFG S S + GT Y+ PE ++G + Sbjct: 127 K-RVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDE 185 Query: 243 QSDIWSMGLSLVEMAVGRYPIPPPDA 268 + D+WS+G+ E VG+ PP +A Sbjct: 186 KVDLWSLGVLCYEFLVGK---PPFEA 208 >3D2K-A nrPDB Length = 272 Score = 110 bits (274), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 63/206 (30%), Positives = 108/206 (52%), Gaps = 8/206 (3%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLI---HLEIKPAIRNQIIRELQVLHECN 122 +DF+ LG G G V+ + S ++A K++ LE K + +Q+ RE+++ Sbjct: 12 EDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLE-KAGVEHQLRREVEIQSHLR 70 Query: 123 SPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLRE 182 P I+ YG F+ + + +E+ G++ + L+K R EQ + L+Y Sbjct: 71 HPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSRFDEQRTATYITELANALSYCHS 130 Query: 183 KHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSV 242 K +++HRD+KP N+L+ S GE+K+ DFG S S + GT Y+ PE ++G + Sbjct: 131 K-RVIHRDIKPENLLLGSNGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDE 189 Query: 243 QSDIWSMGLSLVEMAVGRYPIPPPDA 268 + D+WS+G+ E VG +PP +A Sbjct: 190 KVDLWSLGVLCYEFLVG---MPPFEA 212 >5D9K-A nrPDB Length = 330 Score = 109 bits (273), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 77/234 (32%), Positives = 121/234 (51%), Gaps = 13/234 (5%) Query: 51 EAFLTQKQKVGELKDD--DFEKISELGAGNGGVVF---KVSHKPSGLVMARKLIH---LE 102 E +T K G K D FE + LG G+ G VF K+S + + A K++ L+ Sbjct: 13 EIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLK 72 Query: 103 IKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIP 162 ++ +R ++ R++ V E N P+IV + AF ++G++ + ++ + GG L L K Sbjct: 73 VRDRVRTKMERDILV--EVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFT 130 Query: 163 EQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID--SMA 220 E+ + + L +L I++RD+KP NIL++ G IKL DFG+S + ID A Sbjct: 131 EEDVKFYLAELALALDHLHSL-GIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKA 189 Query: 221 NSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELM 274 SF GT YM+PE + ++ +D WS G+ + EM G P D KE M Sbjct: 190 YSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTM 243 >4XBR-A nrPDB Length = 366 Score = 108 bits (270), Expect = 4e-24, Method: Compositional matrix adjust. Identities = 87/329 (26%), Positives = 154/329 (46%), Gaps = 56/329 (17%) Query: 44 EQQRKRLEAFLTQKQKVGELKD-----DDFEKISELGAGNGGVVFKVSHKPSGLVMARKL 98 E QR E F Q V + D D+F KI G G+ G+V + + SG ++A K Sbjct: 70 EPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKI---GEGSTGIVCIATVRSSGKLVAVKK 126 Query: 99 IHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKA 158 + L K R + E+ ++ + +V Y ++ E+ + ME ++GG+L ++ Sbjct: 127 MDLR-KQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHT 185 Query: 159 GRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS 218 R+ E+ + V +AV++ L+ L + ++HRD+K +IL+ G +KL DFG Q+ Sbjct: 186 -RMNEEQIAAVCLAVLQALSVLHAQ-GVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKE 243 Query: 219 M--ANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFG 276 + S VGT +M+PE + Y + DIWS+G+ ++EM G PP E Sbjct: 244 VPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGE----PPYFNE------ 293 Query: 277 CQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPS-GVFSLEFQ 335 PP+ ++ I + PP+L + S + Sbjct: 294 -----------------------------PPLKAMKM---IRDNLPPRLKNLHKVSPSLK 321 Query: 336 DFVNKCLIKNPAERADLKQLMVHAFIKRS 364 F+++ L+++PA+RA +L+ H F+ ++ Sbjct: 322 GFLDRLLVRDPAQRATAAELLKHPFLAKA 350 >4FIE-A nrPDB Length = 423 Score = 108 bits (270), Expect = 4e-24, Method: Compositional matrix adjust. Identities = 87/329 (26%), Positives = 153/329 (46%), Gaps = 56/329 (17%) Query: 44 EQQRKRLEAFLTQKQKVGELKD-----DDFEKISELGAGNGGVVFKVSHKPSGLVMARKL 98 E QR E F Q V + D D+F KI G G+ G+V + + SG ++A K Sbjct: 127 EPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKI---GEGSTGIVCIATVRSSGKLVAVKK 183 Query: 99 IHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKA 158 + L K R + E+ ++ + +V Y ++ E+ + ME ++GG+L ++ Sbjct: 184 MDLR-KQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHT 242 Query: 159 GRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS 218 R+ E+ + V +AV++ L+ L ++HRD+K +IL+ G +KL DFG Q+ Sbjct: 243 -RMNEEQIAAVCLAVLQALSVL-HAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKE 300 Query: 219 MAN--SFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFG 276 + S VGT +M+PE + Y + DIWS+G+ ++EM G PP E Sbjct: 301 VPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGE----PPYFNE------ 350 Query: 277 CQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPS-GVFSLEFQ 335 PP+ ++ I + PP+L + S + Sbjct: 351 -----------------------------PPLKAMKM---IRDNLPPRLKNLHKVSPSLK 378 Query: 336 DFVNKCLIKNPAERADLKQLMVHAFIKRS 364 F+++ L+++PA+RA +L+ H F+ ++ Sbjct: 379 GFLDRLLVRDPAQRATAAELLKHPFLAKA 407 >2Q0N-A nrPDB Length = 301 Score = 108 bits (269), Expect = 6e-24, Method: Compositional matrix adjust. Identities = 87/329 (26%), Positives = 154/329 (46%), Gaps = 56/329 (17%) Query: 44 EQQRKRLEAFLTQKQKVGELKD-----DDFEKISELGAGNGGVVFKVSHKPSGLVMARKL 98 E QR E F Q V + D D+F KI G G+ G+V + + SG ++A K Sbjct: 5 EPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKI---GEGSTGIVCIATVRSSGKLVAVKK 61 Query: 99 IHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKA 158 + L K R + E+ ++ + +V Y ++ E+ + ME ++GG+L ++ Sbjct: 62 MDLR-KQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHT 120 Query: 159 GRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS 218 R+ E+ + V +AV++ L+ L + ++HRD+K +IL+ G +KL DFG Q+ Sbjct: 121 -RMNEEQIAAVCLAVLQALSVLHAQ-GVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKE 178 Query: 219 M--ANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFG 276 + S VGT +M+PE + Y + DIWS+G+ ++EM G PP E Sbjct: 179 VPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGE----PPYFNE------ 228 Query: 277 CQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPS-GVFSLEFQ 335 PP+ ++ I + PP+L + S + Sbjct: 229 -----------------------------PPLKAMKM---IRDNLPPRLKNLHKVSPSLK 256 Query: 336 DFVNKCLIKNPAERADLKQLMVHAFIKRS 364 F+++ L+++PA+RA +L+ H F+ ++ Sbjct: 257 GFLDRLLVRDPAQRATAAELLKHPFLAKA 285 >4B8L-A nrPDB Length = 286 Score = 108 bits (269), Expect = 6e-24, Method: Compositional matrix adjust. Identities = 65/208 (31%), Positives = 101/208 (48%), Gaps = 5/208 (2%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLI---HLEIKPAIRNQIIRELQVLHECN 122 DDF+ LG G G V+ K + +MA K++ LE K + +Q+ RE+++ Sbjct: 15 DDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLE-KEGVEHQLRREIEIQSHLR 73 Query: 123 SPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLRE 182 P I+ Y F+ I + +E G L + L+K GR EQ + L Y E Sbjct: 74 HPNILRMYNYFHDRKRIYLMLEFAPRGELYKELQKHGRFDEQRSATFMEELADALHYCHE 133 Query: 183 KHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSV 242 + K++HRD+KP N+L+ +GE+K+ DFG S + GT Y+ PE ++G + Sbjct: 134 R-KVIHRDIKPENLLMGYKGELKIADFGWSVHAPSLRRRTMCGTLDYLPPEMIEGKTHDE 192 Query: 243 QSDIWSMGLSLVEMAVGRYPIPPPDAKE 270 + D+W G+ E VG P P E Sbjct: 193 KVDLWCAGVLCYEFLVGMPPFDSPSHTE 220 >4JDH-A nrPDB Length = 346 Score = 108 bits (269), Expect = 6e-24, Method: Compositional matrix adjust. Identities = 87/329 (26%), Positives = 154/329 (46%), Gaps = 56/329 (17%) Query: 44 EQQRKRLEAFLTQKQKVGELKD-----DDFEKISELGAGNGGVVFKVSHKPSGLVMARKL 98 E QR E F Q V + D D+F KI G G+ G+V + + SG ++A K Sbjct: 50 EPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKI---GEGSTGIVCIATVRSSGKLVAVKK 106 Query: 99 IHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKA 158 + L K R + E+ ++ + +V Y ++ E+ + ME ++GG+L ++ Sbjct: 107 MDLR-KQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHT 165 Query: 159 GRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS 218 R+ E+ + V +AV++ L+ L + ++HRD+K +IL+ G +KL DFG Q+ Sbjct: 166 -RMNEEQIAAVCLAVLQALSVLHAQ-GVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKE 223 Query: 219 M--ANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFG 276 + S VGT +M+PE + Y + DIWS+G+ ++EM G PP E Sbjct: 224 VPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGE----PPYFNE------ 273 Query: 277 CQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPS-GVFSLEFQ 335 PP+ ++ I + PP+L + S + Sbjct: 274 -----------------------------PPLKAMKM---IRDNLPPRLKNLHKVSPSLK 301 Query: 336 DFVNKCLIKNPAERADLKQLMVHAFIKRS 364 F+++ L+++PA+RA +L+ H F+ ++ Sbjct: 302 GFLDRLLVRDPAQRATAAELLKHPFLAKA 330 >2BPM-A nrPDB Length = 309 Score = 107 bits (268), Expect = 6e-24, Method: Compositional matrix adjust. Identities = 70/212 (33%), Positives = 113/212 (53%), Gaps = 11/212 (5%) Query: 61 GELKD-DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKP-AIRNQIIRELQVL 118 G L D ++F+K+ ++G G GVV+K +K +G V+A K I L+ + + + IRE+ +L Sbjct: 1 GPLVDMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLL 60 Query: 119 HECNSPYIVGFYGAFYSDGEISICME--HMDGGSLDQVLKKAGRIPEQILGKVSIAVIKG 176 E N P IV +++ ++ + E H D G IP ++ +++G Sbjct: 61 KELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTG-IPLPLIKSYLFQLLQG 119 Query: 177 LTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVS---GQLIDSMANSFVGTRSYMSPE 233 L + H+++HRD+KP N+L+N+ G IKL DFG++ G + + + V T Y +PE Sbjct: 120 LAFC-HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVV-TLWYRAPE 177 Query: 234 RLQGT-HYSVQSDIWSMGLSLVEMAVGRYPIP 264 L G +YS DIWS+G EM R P Sbjct: 178 ILLGCKYYSTAVDIWSLGCIFAEMVTRRALFP 209 >3ZDU-A nrPDB Length = 325 Score = 107 bits (267), Expect = 8e-24, Method: Compositional matrix adjust. Identities = 81/304 (26%), Positives = 146/304 (48%), Gaps = 27/304 (8%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIV 127 +E + ++G G+ G V K HK +G ++A K+ + + ++ +RE++ L + + +V Sbjct: 5 YETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQFHHENLV 64 Query: 128 GFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIM 187 F +I + E +D LD++ + + L K +++ + YL + I+ Sbjct: 65 NLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHS-NNII 123 Query: 188 HRDVKPSNILVNSRGEIKLCDFGVSGQLI--DSMANSFVGTRSYMSPER-LQGTHYSVQS 244 HRD+KP NILV+ G KLCDFG + L + + V TR Y +PE L+ T Y Sbjct: 124 HRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYDDEVATRWYRAPELVLKDTSYGKPV 183 Query: 245 DIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDS 304 DIW++G ++EMA G + P + +L+L+ ++ P + + S Sbjct: 184 DIWALGCMIIEMATGNPYL--PSSSDLDLLH--KIVLKVGNLSPHLQ---------NIFS 230 Query: 305 RPPMAIFELLDYI-----VNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHA 359 + P+ +L + + PKL +G+ + D V+ CL +PA+R L+ H Sbjct: 231 KSPIFAGVVLPQVQHPKNARKKYPKL-NGLLA----DIVHACLQIDPADRISSSDLLHHE 285 Query: 360 FIKR 363 + R Sbjct: 286 YFTR 289 >6ED6-A nrPDB Length = 415 Score = 107 bits (266), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 79/255 (30%), Positives = 129/255 (50%), Gaps = 22/255 (8%) Query: 29 NLEALQKKLEELELDE-----QQRKRLEAFLTQKQKVG------ELKDDDFEKISELGAG 77 N+E+L L L LD ++ K ++ FL + +K+ ++K +D++ + +G G Sbjct: 40 NVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRG 99 Query: 78 NGGVVFKVSHKPSGLVMARKLI-HLE-IKPAIRNQIIRELQVLHECNSPYIVGFYGAFYS 135 G V V HK S V A KL+ E IK + E ++ NSP++V + AF Sbjct: 100 AFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQD 159 Query: 136 DGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSN 195 D + + ME+M GG L ++ +PE+ + V+ L + ++HRDVKP N Sbjct: 160 DRYLYMVMEYMPGGDLVNLMSNYD-VPEKWAKFYTAEVVLALDAIHSM-GLIHRDVKPDN 217 Query: 196 ILVNSRGEIKLCDFGVSGQLIDS---MANSFVGTRSYMSPERLQGT----HYSVQSDIWS 248 +L++ G +KL DFG ++ ++ ++ VGT Y+SPE L+ Y + D WS Sbjct: 218 MLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGGDGFYGRECDWWS 277 Query: 249 MGLSLVEMAVGRYPI 263 +G+ L EM VG P Sbjct: 278 VGVFLYEMLVGDTPF 292 >2XNP-A nrPDB Length = 279 Score = 106 bits (265), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 68/221 (30%), Positives = 117/221 (52%), Gaps = 13/221 (5%) Query: 64 KDDDFEKISELGAGNGGVVFKVSHKPSGLVMARK-LIHLEIKPAIRNQIIRELQVLHECN 122 + +D+E + +G G+ G K+ K G ++ K L + + A + ++ E+ +L E Sbjct: 4 RAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELK 63 Query: 123 SPYIVGFYGAFY--SDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTY- 179 P IV +Y ++ + I ME+ +GG L V+ K + + + + + V+ LT Sbjct: 64 HPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLA 123 Query: 180 LREKHK-------IMHRDVKPSNILVNSRGEIKLCDFGVSGQLI--DSMANSFVGTRSYM 230 L+E H+ ++HRD+KP+N+ ++ + +KL DFG++ L S A +FVGT YM Sbjct: 124 LKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYM 183 Query: 231 SPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKEL 271 SPE++ Y+ +SDIWS+G L E+ P KEL Sbjct: 184 SPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKEL 224 >5X3F-B nrPDB Length = 393 Score = 105 bits (262), Expect = 3e-23, Method: Compositional matrix adjust. Identities = 70/242 (28%), Positives = 124/242 (51%), Gaps = 9/242 (3%) Query: 25 SAETNLEALQKKLEELE--LDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVV 82 S NL A KKL +++ L + + L+ + T Q +L D F++I LG G+ G V Sbjct: 43 SQSANLLAEAKKLNDVQAFLAKAKEDFLKKWETPSQNTAQL--DQFDRIKTLGTGSFGRV 100 Query: 83 FKVSHKPSGLVMARKLIHLE--IKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEIS 140 V HK SG A K++ + +K + E ++L N P++V +F + + Sbjct: 101 MLVKHKESGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLY 160 Query: 141 ICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNS 200 + ME++ GG + L++ GR E + ++ YL +++RD+KP N+L++ Sbjct: 161 MVMEYVAGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL-DLIYRDLKPENLLIDQ 219 Query: 201 RGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGR 260 +G I++ DFG + + + + GT Y++PE + Y+ D W++G+ + EMA G Sbjct: 220 QGYIQVTDFGFAKR-VKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAG- 277 Query: 261 YP 262 YP Sbjct: 278 YP 279 >5G6V-A nrPDB Length = 324 Score = 105 bits (262), Expect = 3e-23, Method: Compositional matrix adjust. Identities = 74/233 (31%), Positives = 119/233 (51%), Gaps = 11/233 (4%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPY 125 + + K+ +LG G V+K K + ++A K I LE + IRE+ +L + Sbjct: 2 ETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHAN 61 Query: 126 IVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSI-AVIKGLTYLREKH 184 IV + +++ +++ E++D L Q L G I K+ + +++GL Y + Sbjct: 62 IVTLHDIIHTEKSLTLVFEYLDK-DLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCH-RQ 119 Query: 185 KIMHRDVKPSNILVNSRGEIKLCDFGV--SGQLIDSMANSFVGTRSYMSPERLQG-THYS 241 K++HRD+KP N+L+N RGE+KL DFG+ + + ++ V T Y P+ L G T YS Sbjct: 120 KVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYDNEVVTLWYRPPDILLGSTDYS 179 Query: 242 VQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPG 294 Q D+W +G EMA GR P+ P E +L F ++ G TP PG Sbjct: 180 TQIDMWGVGCIFYEMATGR-PLFPGSTVEEQLHFIFRILG----TPTEETWPG 227 >2F57-A nrPDB Length = 317 Score = 105 bits (262), Expect = 4e-23, Method: Compositional matrix adjust. Identities = 76/293 (25%), Positives = 141/293 (48%), Gaps = 48/293 (16%) Query: 73 ELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGA 132 ++G G+ G+V + K +G +A K + L K R + E+ ++ + + +V Y + Sbjct: 52 KIGEGSTGIVCIATEKHTGKQVAVKKMDLR-KQQRRELLFNEVVIMRDYHHDNVVDMYSS 110 Query: 133 FYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVK 192 + E+ + ME ++GG+L ++ R+ E+ + V ++V++ L+YL + ++HRD+K Sbjct: 111 YLVGDELWVVMEFLEGGALTDIVTHT-RMNEEQIATVCLSVLRALSYLHNQ-GVIHRDIK 168 Query: 193 PSNILVNSRGEIKLCDFGVSGQLIDSM--ANSFVGTRSYMSPERLQGTHYSVQSDIWSMG 250 +IL+ S G IKL DFG Q+ + S VGT +M+PE + Y + DIWS+G Sbjct: 169 SDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLG 228 Query: 251 LSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAI 310 + ++EM G PP E PP+ Sbjct: 229 IMVIEMIDGE----PPYFNE-----------------------------------PPL-- 247 Query: 311 FELLDYIVNEPPPKLPS-GVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIK 362 + + I + PP++ S + F++ L++ P++RA ++L+ H F+K Sbjct: 248 -QAMRRIRDSLPPRVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLK 299 >1U5R-A nrPDB Length = 348 Score = 105 bits (261), Expect = 5e-23, Method: Compositional matrix adjust. Identities = 87/326 (26%), Positives = 143/326 (43%), Gaps = 69/326 (21%) Query: 59 KVGELKDDD-------------FEKISELGAGN-GGVVFKVSHKPSGLVMARKLIHLEIK 104 + G LKD D F + E+G G+ G V F + S +V +K+ + + Sbjct: 34 RAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQ 93 Query: 105 PAIRNQ-IIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPE 163 + Q II+E++ L + P + + G + + + ME+ G + D + + E Sbjct: 94 SNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQE 153 Query: 164 QILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSF 223 + V+ ++GL YL H ++HRDVK NIL++ G +KL DFG + I + ANSF Sbjct: 154 VEIAAVTHGALQGLAYL-HSHNMIHRDVKAGNILLSEPGLVKLGDFGSAS--IMAPANSF 210 Query: 224 VGTRSYMSPERLQGT---HYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVE 280 VGT +M+PE + Y + D+WS+G++ +E+A Sbjct: 211 VGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELA----------------------- 247 Query: 281 GDAAETPPRPRTPGRPLSSYGMDSRPP---MAIFELLDYIVNEPPPKLPSGVFSLEFQDF 337 + +PP M L +I P L SG +S F++F Sbjct: 248 ----------------------ERKPPLFNMNAMSALYHIAQNESPALQSGHWSEYFRNF 285 Query: 338 VNKCLIKNPAERADLKQLMVHAFIKR 363 V+ CL K P +R + L+ H F+ R Sbjct: 286 VDSCLQKIPQDRPTSEVLLKHRFVLR 311 >1FOT-A nrPDB Length = 318 Score = 103 bits (258), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 63/206 (30%), Positives = 103/206 (50%), Gaps = 18/206 (8%) Query: 67 DFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE------ 120 DF+ + LG G+ G V + + +G A K++ EI ++R QV H Sbjct: 7 DFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEI-------VVRLKQVEHTNDERLM 59 Query: 121 ---CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGL 177 P+I+ +G F +I + M++++GG L +L+K+ R P + + V L Sbjct: 60 LSIVTHPFIIRMWGTFQDAQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLAL 119 Query: 178 TYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQG 237 YL K I++RD+KP NIL++ G IK+ DFG + + D + + GT Y++PE + Sbjct: 120 EYLHSK-DIIYRDLKPENILLDKNGHIKITDFGFAKYVPD-VTYTLCGTPDYIAPEVVST 177 Query: 238 THYSVQSDIWSMGLSLVEMAVGRYPI 263 Y+ D WS G+ + EM G P Sbjct: 178 KPYNKSIDWWSFGILIYEMLAGYTPF 203 >2GCD-A nrPDB Length = 309 Score = 103 bits (258), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 85/312 (27%), Positives = 140/312 (44%), Gaps = 59/312 (18%) Query: 63 LKDDD---FEKISELGAGN-GGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQ-IIRELQV 117 KDD F + E+G G+ G V F + S +V +K+ + + + Q II+E++ Sbjct: 9 FKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRF 68 Query: 118 LHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGL 177 L + P + + G + + + ME+ G + D + + E + V+ ++GL Sbjct: 69 LQKLRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGL 128 Query: 178 TYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQG 237 YL H ++HRDVK NIL++ G +KL DFG + I + ANSFVGT +M+PE + Sbjct: 129 AYL-HSHNMIHRDVKAGNILLSEPGLVKLGDFGSAS--IMAPANSFVGTPYWMAPEVILA 185 Query: 238 T---HYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPG 294 Y + D+WS+G++ +E+A Sbjct: 186 MDEGQYDGKVDVWSLGITCIELA------------------------------------- 208 Query: 295 RPLSSYGMDSRPP---MAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERAD 351 + +PP M L +I P L SG +S F++FV+ CL K P +R Sbjct: 209 --------ERKPPLFNMNAMSALYHIAQNESPALQSGHWSEYFRNFVDSCLQKIPQDRPT 260 Query: 352 LKQLMVHAFIKR 363 + L+ H F+ R Sbjct: 261 SEVLLKHRFVLR 272 >6E9W-A nrPDB Length = 443 Score = 103 bits (256), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 78/258 (30%), Positives = 128/258 (49%), Gaps = 22/258 (8%) Query: 26 AETNLEALQKKLEELELDE-----QQRKRLEAFLTQ-KQKVGELKD-----DDFEKISEL 74 +E N + L L+ L D ++ K ++ FL++ K + +++D +D+E + + Sbjct: 51 SEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINKIRDLRMKAEDYEVVKVI 110 Query: 75 GAGNGGVVFKVSHKPSGLVMARKLI-HLE-IKPAIRNQIIRELQVLHECNSPYIVGFYGA 132 G G G V V HK + V A KL+ E IK + E ++ NSP++V + A Sbjct: 111 GRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYA 170 Query: 133 FYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVK 192 F D + + ME+M GG L ++ +PE+ + V+ L + +HRDVK Sbjct: 171 FQDDRYLYMVMEYMPGGDLVNLMSNYD-VPEKWARFYTAEVVLALDAI-HSMGFIHRDVK 228 Query: 193 PSNILVNSRGEIKLCDFGVSGQLIDS---MANSFVGTRSYMSPERLQGT----HYSVQSD 245 P N+L++ G +KL DFG ++ ++ VGT Y+SPE L+ +Y + D Sbjct: 229 PDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECD 288 Query: 246 IWSMGLSLVEMAVGRYPI 263 WS+G+ L EM VG P Sbjct: 289 WWSVGVFLYEMLVGDTPF 306 >6E2O-A nrPDB Length = 295 Score = 102 bits (255), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 88/292 (30%), Positives = 143/292 (48%), Gaps = 60/292 (20%) Query: 91 GLVMARKLIHLEIKPAIRN---QIIRELQVLHE-------CNSPYIVGFYGAFYSDGEIS 140 G+V A + + +++ AI+ + R Q LHE IV + G+F +G I Sbjct: 36 GIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFSENGFIK 95 Query: 141 ICMEHMDGGSLDQVLK-KAGRIP--EQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNIL 197 I ME + GGSL +L+ K G + EQ +G + +++GL YL + ++I+HRD+K N+L Sbjct: 96 IFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHD-NQIVHRDIKGDNVL 154 Query: 198 VNS-RGEIKLCDFGVSGQL--IDSMANSFVGTRSYMSPERLQG--THYSVQSDIWSMGLS 252 +N+ G +K+ DFG S +L I+ +F GT YM+PE + Y +DIWS+G + Sbjct: 155 INTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCT 214 Query: 253 LVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFE 312 ++EMA G+ P EL P A+F+ Sbjct: 215 IIEMATGKPPF-------YEL------------------------------GEPQAAMFK 237 Query: 313 LLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRS 364 + + V+ P++P + S E + F+ KC +P +RA L+V F+K S Sbjct: 238 VGMFKVH---PEIPESM-SAEAKAFILKCFEPDPDKRACANDLLVDEFLKVS 285 >1UA2-A nrPDB Length = 346 Score = 101 bits (252), Expect = 5e-22, Method: Compositional matrix adjust. Identities = 88/302 (29%), Positives = 140/302 (46%), Gaps = 36/302 (11%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHL----EIKPAIRNQIIRELQVLHECNS 123 +EK+ LG G V+K K + ++A K I L E K I +RE+++L E + Sbjct: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 Query: 124 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRI--PEQILGKVSIAVIKGLTYLR 181 P I+G AF IS+ + M+ L+ ++K + P I + + ++GL YL Sbjct: 72 PNIIGLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYM-LMTLQGLEYLH 129 Query: 182 EKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL--IDSMANSFVGTRSYMSPERLQGTH 239 + H I+HRD+KP+N+L++ G +KL DFG++ + V TR Y +PE L G Sbjct: 130 Q-HWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGAR 188 Query: 240 -YSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLS 298 Y V D+W++G L E+ + R P P D+ +L + G TP + P Sbjct: 189 MYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETLG----TPTEEQWP----- 238 Query: 299 SYGMDSRPPMAIFELLDYIVNEPPPKLP-SGVFSL---EFQDFVNKCLIKNPAERADLKQ 354 M S P DY+ + P +P +FS + D + + NP R Q Sbjct: 239 --DMCSLP--------DYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQ 288 Query: 355 LM 356 + Sbjct: 289 AL 290 >5DYK-A nrPDB Length = 853 Score = 100 bits (249), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 64/211 (30%), Positives = 104/211 (49%), Gaps = 4/211 (1%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE--IKPAIRNQIIRELQVLHECNS 123 D+ E +G G G V V HKP+ + A K + I +N I E ++ E + Sbjct: 539 DELETERIIGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINLNQQNNIKLEREITAENDH 598 Query: 124 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREK 183 P+I+ F E + GG L ++K G + + ++I + YL E+ Sbjct: 599 PFIIRLVRTFKDSKYFYFLTELVTGGELYDAIRKLGLLSKSQAQFYLGSIILAIEYLHER 658 Query: 184 HKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQ 243 + I++RD+KP NIL++ +G +KL DFG + + + A + VGT YM+PE + G Y Sbjct: 659 N-IVYRDLKPENILLDKQGYVKLIDFGCAKK-VQGRAYTLVGTPHYMAPEVILGKGYGCT 716 Query: 244 SDIWSMGLSLVEMAVGRYPIPPPDAKELELM 274 DIW++G+ L E G P + +LE+ Sbjct: 717 VDIWALGICLYEFICGPLPFGNDEEDQLEIF 747 >3A8W-A nrPDB Length = 345 Score = 100 bits (249), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 58/202 (28%), Positives = 108/202 (53%), Gaps = 6/202 (2%) Query: 67 DFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEI--KPAIRNQIIRELQVLHEC-NS 123 DF+ + +G G+ V V K + + A K++ E+ + + E V + N Sbjct: 10 DFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNH 69 Query: 124 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREK 183 P++VG + F ++ + +E+++GG L +++ ++PE+ S + L YL E+ Sbjct: 70 PFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHER 129 Query: 184 HKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLI--DSMANSFVGTRSYMSPERLQGTHYS 241 I++RD+K N+L++S G IKL D+G+ + + ++F GT +Y++PE L+G Y Sbjct: 130 -GIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYG 188 Query: 242 VQSDIWSMGLSLVEMAVGRYPI 263 D W++G+ + EM GR P Sbjct: 189 FSVDWWALGVLMFEMMAGRSPF 210 >4WB7-A nrPDB Length = 405 Score = 100 bits (248), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 58/199 (29%), Positives = 104/199 (52%), Gaps = 5/199 (2%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE--IKPAIRNQIIRELQVLHECNS 123 D FE+I LG G+ G V V HK +G A K++ + +K + E ++L N Sbjct: 96 DQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 155 Query: 124 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREK 183 P++V +F + + + ME++ GG + L++ GR E + ++ YL Sbjct: 156 PFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 215 Query: 184 HKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQ 243 +++RD+KP N+L++ +G I++ DFG + + + + GT Y++PE + Y+ Sbjct: 216 -DLIYRDLKPENLLIDQQGYIQVTDFGFAKR-VKGRTWTLCGTPEYLAPEIILSKGYNKA 273 Query: 244 SDIWSMGLSLVEMAVGRYP 262 D W++G+ + EMA G YP Sbjct: 274 VDWWALGVLIYEMAAG-YP 291 >2F9G-A nrPDB Length = 353 Score = 100 bits (248), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 93/324 (28%), Positives = 151/324 (46%), Gaps = 53/324 (16%) Query: 67 DFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYI 126 DF+ S LG G GVV +HKP+G ++A K I KP + +RE+++L I Sbjct: 12 DFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENI 71 Query: 127 VGFYG-----AFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILG--KVSIAVIKGLTY 179 + + +F + E+ I E M L +V I Q+L + + + L Sbjct: 72 ITIFNIQRPDSFENFNEVYIIQELMQT-DLHRV------ISTQMLSDDHIQYFIYQTLRA 124 Query: 180 LREKH--KIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANS------------FVG 225 ++ H ++HRD+KPSN+L+NS ++K+CDFG++ + +S A++ +V Sbjct: 125 VKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVA 184 Query: 226 TRSYMSPE-RLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAK-ELELMFGC----QV 279 TR Y +PE L YS D+WS G L E+ + R P D + +L L+FG Sbjct: 185 TRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHS 244 Query: 280 EGDA-AETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFV 338 + D PR R + L Y P A E + VN P G+ D + Sbjct: 245 DNDLRCIESPRAREYIKSLPMY------PAAPLEKMFPRVN------PKGI------DLL 286 Query: 339 NKCLIKNPAERADLKQLMVHAFIK 362 + L+ +PA+R K+ + H +++ Sbjct: 287 QRMLVFDPAKRITAKEALEHPYLQ 310 >6GU6-A nrPDB Length = 302 Score = 100 bits (248), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 97/319 (30%), Positives = 152/319 (47%), Gaps = 44/319 (13%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKP-AIRNQIIRELQVLHECNSP 124 +D+ KI ++G G GVV+K HK +G V+A K I LE + + + IRE+ +L E P Sbjct: 7 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 66 Query: 125 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKA------GRIPEQILGKVSI-AVIKGL 177 IV D + + E + S+D LKK G+ + L K + +++G+ Sbjct: 67 NIVSLQDVLMQDSRLYLIFEFL---SMD--LKKYLDSIPPGQYMDSSLVKSYLYQILQGI 121 Query: 178 TYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVS---GQLIDSMANSFVGTRSYMSPER 234 + + +++HRD+KP N+L++ +G IKL DFG++ G I + V T Y SPE Sbjct: 122 VFCHSR-RVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVV-TLWYRSPEV 179 Query: 235 LQGT-HYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTP 293 L G+ YS DIWS+G E+A + P+ D+ E++ +F A TP P Sbjct: 180 LLGSARYSTPVDIWSIGTIFAELATKK-PLFHGDS-EIDQLFRI---FRALGTPNNEVWP 234 Query: 294 GRPLSSYGMDSRPPMAIFELLDYIVNEP---PPKLPSGVFSLEFQ--DFVNKCLIKNPAE 348 + L DY P P L S V +L+ D ++K LI +PA+ Sbjct: 235 ---------------EVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAK 279 Query: 349 RADLKQLMVHAFIKRSDAE 367 R K + H + D + Sbjct: 280 RISGKMALNHPYFNDLDNQ 298 >5WAX-A nrPDB Length = 310 Score = 99.8 bits (247), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 83/317 (26%), Positives = 142/317 (44%), Gaps = 60/317 (18%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHL--EIKPAIRNQIIRELQVLHECNS 123 D +E + ++G+GN GV + ++ G ++A K I +I ++ +II + H Sbjct: 11 DRYELVRDIGSGNFGVARLMRNRADGQLVAVKYIERGEKIDENVQREIINHRSLRH---- 66 Query: 124 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREK 183 P I+ F + ++I ME+ GG L + + AGR E +I G++Y Sbjct: 67 PNIIRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHSM 126 Query: 184 HKIMHRDVKPSNILVN--SRGEIKLCDFGVS-GQLIDSMANSFVGTRSYMSPERLQGTHY 240 ++ HRD+K N L++ + +K+CDFG S ++ S S VGT +Y++PE L Y Sbjct: 127 -QVCHRDLKLENTLLDGSTAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEY 185 Query: 241 SVQ-SDIWSMGLSLVEMAVGRYPIPPPDA-----KELELMFGCQVEGDAAETPPRPRTPG 294 + +D+WS G++L M VG YP PD K ++ + G Q Sbjct: 186 DGKVADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRILGVQ---------------- 229 Query: 295 RPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQ 354 + + DY+ P E QD +++ + NPA R + + Sbjct: 230 ----------------YSIPDYVHISP-----------ECQDLISRIFVANPATRITIPE 262 Query: 355 LMVH-AFIKRSDAEEVD 370 + H F+K A+ +D Sbjct: 263 IRNHPWFLKNLPADLMD 279 >4BGQ-A nrPDB Length = 304 Score = 99.8 bits (247), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 65/217 (29%), Positives = 114/217 (52%), Gaps = 7/217 (3%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMA-RKLIHLEIKPAIRNQIIRELQVLHECNSP 124 + FE + +G G GVV K HK + ++A +K E ++ +REL++L Sbjct: 12 NKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQE 71 Query: 125 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKH 184 IV AF G++ + E+++ L+ + + +P + + +IK + + K+ Sbjct: 72 NIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCH-KN 130 Query: 185 KIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSF---VGTRSYMSPERLQGTHYS 241 I+HRD+KP N+L++ +KLCDFG + L + ++ V TR Y SPE L G Y Sbjct: 131 DIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYDEEVATRWYRSPELLLGAPYG 190 Query: 242 VQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQ 278 D+WS+G L E++ G+ P+ P ++ E++ +F Q Sbjct: 191 KSVDMWSVGCILGELSDGQ-PLFPGES-EIDQLFTIQ 225 >2JDO-A nrPDB Length = 342 Score = 99.8 bits (247), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 60/211 (28%), Positives = 103/211 (48%), Gaps = 7/211 (3%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQI---IRELQVLHECN 122 +DF+ + LG G G V V K +G A K++ E+ A ++++ + E +VL Sbjct: 10 NDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIA-KDEVAHTVTESRVLQNTR 68 Query: 123 SPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLRE 182 P++ AF + + ME+ +GG L L + E+ ++ L YL Sbjct: 69 HPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHS 128 Query: 183 KHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMAN--SFVGTRSYMSPERLQGTHY 240 + +++RD+K N++++ G IK+ DFG+ + I A +F GT Y++PE L+ Y Sbjct: 129 R-DVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDY 187 Query: 241 SVQSDIWSMGLSLVEMAVGRYPIPPPDAKEL 271 D W +G+ + EM GR P D + L Sbjct: 188 GRAVDWWGLGVVMYEMMCGRLPFYNQDHERL 218 >5KCV-A nrPDB Length = 460 Score = 99.8 bits (247), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 59/210 (28%), Positives = 99/210 (47%), Gaps = 4/210 (1%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRN--QIIRELQVLHECNS 123 ++FE + LG G G V V K +G A K++ E+ A + E +VL Sbjct: 162 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 221 Query: 124 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREK 183 P++ +F + + ME+ +GG L L + E ++ L YL + Sbjct: 222 PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSE 281 Query: 184 HKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMAN--SFVGTRSYMSPERLQGTHYS 241 +++RD+K N++++ G IK+ DFG+ + I A +F GT Y++PE L+ Y Sbjct: 282 KNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYG 341 Query: 242 VQSDIWSMGLSLVEMAVGRYPIPPPDAKEL 271 D W +G+ + EM GR P D ++L Sbjct: 342 RAVDWWGLGVVMYEMMCGRLPFYNQDHEKL 371 >3MV5-A nrPDB Length = 342 Score = 99.8 bits (247), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 59/210 (28%), Positives = 99/210 (47%), Gaps = 4/210 (1%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRN--QIIRELQVLHECNS 123 ++FE + LG G G V V K +G A K++ E+ A + E +VL Sbjct: 10 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 69 Query: 124 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREK 183 P++ +F + + ME+ +GG L L + E ++ L YL + Sbjct: 70 PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSE 129 Query: 184 HKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMAN--SFVGTRSYMSPERLQGTHYS 241 +++RD+K N++++ G IK+ DFG+ + I A +F GT Y++PE L+ Y Sbjct: 130 KNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYG 189 Query: 242 VQSDIWSMGLSLVEMAVGRYPIPPPDAKEL 271 D W +G+ + EM GR P D ++L Sbjct: 190 RAVDWWGLGVVMYEMMCGRLPFYNQDHEKL 219 >5N23-A nrPDB Length = 352 Score = 99.4 bits (246), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 68/240 (28%), Positives = 117/240 (48%), Gaps = 10/240 (4%) Query: 29 NLEALQKKLEELELDEQQRKRLEAFLTQ----KQKVGELKDDDFEKISELGAGNGGVVFK 84 N A +K E+ + E K E FL + Q L D FE+I LG G+ G V Sbjct: 3 NAAAAKKGSEQESVKEFLAKAKEDFLKKWESPAQNTAHL--DQFERIRTLGTGSFGRVML 60 Query: 85 VSHKPSGLVMARKLIHLE--IKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISIC 142 V HK +G A K++ + +K + E ++ N P++V +F + + + Sbjct: 61 VKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRIQQAVNFPFLVKLEFSFKDNSNLYMV 120 Query: 143 MEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRG 202 +E+ GG + L++ GR E + ++ YL +++RD+KP N+L++ +G Sbjct: 121 LEYAPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL-DLIYRDLKPENLLIDQQG 179 Query: 203 EIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYP 262 IK+ DFG + ++ + GT Y++PE + Y+ D W++G+ + EMA G YP Sbjct: 180 YIKVADFGFAKRVKGRTPWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAG-YP 238 >4L42-A nrPDB Length = 346 Score = 99.0 bits (245), Expect = 4e-21, Method: Compositional matrix adjust. Identities = 70/227 (30%), Positives = 120/227 (52%), Gaps = 22/227 (9%) Query: 68 FEKISELGAGNGGVVF---KVSHKPSGLVMARKLIHLEIKPAIRN-----QIIRELQVLH 119 FE + LG G G VF KV+ +G + A K+ L+ +RN E +L Sbjct: 20 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKV--LKKAMIVRNAKDTAHTKAERNILE 77 Query: 120 ECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQI----LGKVSIAVIK 175 E P+IV AF + G++ + +E++ GG L L++ G E L ++S+A Sbjct: 78 EVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMA--- 134 Query: 176 GLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID--SMANSFVGTRSYMSPE 233 L +L +K I++RD+KP NI++N +G +KL DFG+ + I ++ ++F GT YM+PE Sbjct: 135 -LGHLHQK-GIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPE 192 Query: 234 RLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKE-LELMFGCQV 279 L + ++ D WS+G + +M G P + K+ ++ + C++ Sbjct: 193 ILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKL 239 >4RLP-A nrPDB Length = 288 Score = 98.6 bits (244), Expect = 4e-21, Method: Compositional matrix adjust. Identities = 69/223 (30%), Positives = 118/223 (52%), Gaps = 21/223 (9%) Query: 62 ELKDDDFEKISELGAGNGGVVF---KVSHKPSGLVMARKLIHLEIKPAIRN-----QIIR 113 +++ + FE + LG G G VF KV+ +G + A K+ L+ +RN Sbjct: 1 KIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKV--LKKAMIVRNAKDTAHTKA 58 Query: 114 ELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQI----LGKV 169 E +L E P+IV AF + G++ + +E++ GG L L++ G E L ++ Sbjct: 59 ERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEI 118 Query: 170 SIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID--SMANSFVGTR 227 S+A L +L +K I++RD+KP NI++N +G +KL DFG+ + I ++ ++F GT Sbjct: 119 SMA----LGHLHQK-GIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTI 173 Query: 228 SYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKE 270 YM+PE L + ++ D WS+G + +M G P + K+ Sbjct: 174 EYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKK 216 >4FR4-A nrPDB Length = 384 Score = 98.6 bits (244), Expect = 4e-21, Method: Compositional matrix adjust. Identities = 57/204 (27%), Positives = 108/204 (52%), Gaps = 9/204 (4%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQI---IRELQVLHECN 122 D FE + +G G+ G V V + + A K ++ + K RN++ +ELQ++ Sbjct: 15 DHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQ-KCVERNEVRNVFKELQIMQGLE 73 Query: 123 SPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLRE 182 P++V + +F + ++ + ++ + GG L L++ E+ + ++ L YL+ Sbjct: 74 HPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELVMALDYLQN 133 Query: 183 KHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL-IDSMANSFVGTRSYMSPERL---QGT 238 + +I+HRD+KP NIL++ G + + DF ++ L ++ + GT+ YM+PE +G Sbjct: 134 Q-RIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQITTMAGTKPYMAPEMFSSRKGA 192 Query: 239 HYSVQSDIWSMGLSLVEMAVGRYP 262 YS D WS+G++ E+ GR P Sbjct: 193 GYSFAVDWWSLGVTAYELLRGRRP 216 >5F9E-A nrPDB Length = 353 Score = 98.6 bits (244), Expect = 4e-21, Method: Compositional matrix adjust. Identities = 63/215 (29%), Positives = 105/215 (48%), Gaps = 6/215 (2%) Query: 62 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEI---KPAIRNQIIRELQVL 118 +LK +DFE LG G+ G VF K + A K + ++ + ++ + + Sbjct: 15 KLKIEDFELHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLS 74 Query: 119 HECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLT 178 P++ + F + + ME+++GG L ++ + + +I GL Sbjct: 75 LAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQ 134 Query: 179 YLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQ--LIDSMANSFVGTRSYMSPERLQ 236 +L K I++RD+K NIL++ G IK+ DFG+ + L D+ N F GT Y++PE L Sbjct: 135 FLHSK-GIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNEFCGTPDYIAPEILL 193 Query: 237 GTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKEL 271 G Y+ D WS G+ L EM +G+ P D +EL Sbjct: 194 GQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEEL 228 >3NIZ-A nrPDB Length = 311 Score = 98.2 bits (243), Expect = 5e-21, Method: Compositional matrix adjust. Identities = 90/312 (28%), Positives = 152/312 (48%), Gaps = 32/312 (10%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIK-PAIRNQIIRELQVLHECNSP 124 + ++K+ ++G G GVV+K + G ++A K I L+ + I + IRE+ +L E + P Sbjct: 21 EKYQKLEKVGEGTYGVVYK-AKDSQGRIVALKRIRLDAEDEGIPSTAIREISLLKELHHP 79 Query: 125 YIVGFYGAFYSDGEISICMEHMDGGSLDQVL--KKAGRIPEQILGKVSI-AVIKGLTYLR 181 IV +S+ +++ E M+ L +VL K G QI K+ + +++G+ + Sbjct: 80 NIVSLIDVIHSERCLTLVFEFMEK-DLKKVLDENKTGLQDSQI--KIYLYQLLRGVAHCH 136 Query: 182 EKHKIMHRDVKPSNILVNSRGEIKLCDFGVS---GQLIDSMANSFVGTRSYMSPERLQGT 238 + H+I+HRD+KP N+L+NS G +KL DFG++ G + S + V T Y +P+ L G+ Sbjct: 137 Q-HRILHRDLKPQNLLINSDGALKLADFGLARAFGIPVRSYTHEVV-TLWYRAPDVLMGS 194 Query: 239 -HYSVQSDIWSMGLSLVEMAVGRYPIPP--PDAKELELMFGCQVEGDAAETPPRPRTPGR 295 YS DIWS+G EM G+ P+ P D +L +F + E P P Sbjct: 195 KKYSTSVDIWSIGCIFAEMITGK-PLFPGVTDDDQLPKIFSILGTPNPREWPQVQELP-- 251 Query: 296 PLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQL 355 + + +FE +P + G F E D ++ L +P +R + Sbjct: 252 ------LWKQRTFQVFE------KKPWSSIIPG-FCQEGIDLLSNMLCFDPNKRISARDA 298 Query: 356 MVHAFIKRSDAE 367 M H + K D + Sbjct: 299 MNHPYFKDLDPQ 310 >1V0B-A nrPDB Length = 288 Score = 97.8 bits (242), Expect = 7e-21, Method: Compositional matrix adjust. Identities = 90/311 (28%), Positives = 146/311 (46%), Gaps = 35/311 (11%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIK-PAIRNQIIRELQVLHECNSP 124 + + + ++G G GVV+K + G A K I LE + I + IRE+ +L E Sbjct: 2 EKYHGLEKIGEGTYGVVYKAQNN-YGETFALKKIRLEKEDEGIPSTTIREISILKELKHS 60 Query: 125 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVS-----IAVIKGLTY 179 IV Y ++ + + EH LDQ LKK + E L V+ + ++ G+ Y Sbjct: 61 NIVKLYDVIHTKKRLVLVFEH-----LDQDLKKLLDVCEGGLESVTAKSFLLQLLNGIAY 115 Query: 180 LREKHKIMHRDVKPSNILVNSRGEIKLCDFGVS---GQLIDSMANSFVGTRSYMSPERLQ 236 ++ +++HRD+KP N+L+N GE+K+ DFG++ G + + V T Y +P+ L Sbjct: 116 CHDR-RVLHRDLKPQNLLINREGELKIADFGLARAFGIPVRKYTHEVV-TLWYRAPDVLM 173 Query: 237 GT-HYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPG- 294 G+ YS DIWS+G EM G P+ P ++ +LM ++ G TP P Sbjct: 174 GSKKYSTTIDIWSVGCIFAEMVNGA-PLFPGVSEADQLMRIFRILG----TPNSKNWPNV 228 Query: 295 RPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQ 354 L Y P ++E L P G+ D ++K L +P +R KQ Sbjct: 229 TELPKYD----PNFTVYEPL------PWESFLKGLDESGI-DLLSKMLKLDPNQRITAKQ 277 Query: 355 LMVHAFIKRSD 365 + HA+ K ++ Sbjct: 278 ALEHAYFKENN 288 >5FET-A nrPDB Length = 847 Score = 97.4 bits (241), Expect = 8e-21, Method: Compositional matrix adjust. Identities = 63/203 (31%), Positives = 100/203 (49%), Gaps = 4/203 (1%) Query: 74 LGAGNGGVVFKVSHKPSGLVMARKLIHLE--IKPAIRNQIIRELQVLHECNSPYIVGFYG 131 +G G G V V HKP+ + A K + I +N I E ++ E + P+I+ Sbjct: 541 IGRGTFGTVKLVHHKPTQIRYALKCVSKRSIISLNQQNNIKLEREITAENDHPFIIRLVR 600 Query: 132 AFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDV 191 F E + GG L ++K G + + ++I + YL E++ I++RD+ Sbjct: 601 TFKDSNCFYFLTELVTGGELYDAIRKLGLLSKPQAQFYLGSIILAIEYLHERN-IVYRDL 659 Query: 192 KPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGL 251 KP NIL++ +G +KL DFG + + I A + VGT YM+PE + G Y DIW++G+ Sbjct: 660 KPENILLDKQGYVKLIDFGCAKK-IQGRAYTLVGTPHYMAPEVILGKGYGCTVDIWALGV 718 Query: 252 SLVEMAVGRYPIPPPDAKELELM 274 L E G P +LE+ Sbjct: 719 CLYEFICGPLPFGNDQEDQLEIF 741 >4I6B-A nrPDB Length = 308 Score = 97.1 bits (240), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 60/201 (29%), Positives = 105/201 (52%), Gaps = 5/201 (2%) Query: 74 LGAGNGGVVFKVSHKPSGLVMARKLI-HLEI-KPAIRNQIIRELQVLHECNSPYIVGFYG 131 LG G ++++ + V A K+I H + KP R +I +E+++ + ++V FY Sbjct: 36 LGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKIDKEIELHRILHHKHVVQFYH 95 Query: 132 AFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDV 191 F I I +E+ S+ +LK + E + ++ GL YL E+ +I+HRD+ Sbjct: 96 YFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQ-EILHRDL 154 Query: 192 KPSNILVNSRGEIKLCDFGVSGQL--IDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSM 249 K N +N E+K+ DFG++ +L ++ + GT +Y+SPE L + +SDIW++ Sbjct: 155 KLGNFFINESMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGAESDIWAL 214 Query: 250 GLSLVEMAVGRYPIPPPDAKE 270 G + M +GR P + KE Sbjct: 215 GCVMYTMLLGRPPFETTNLKE 235 >5LOH-A nrPDB Length = 341 Score = 96.3 bits (238), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 57/171 (33%), Positives = 87/171 (50%), Gaps = 12/171 (7%) Query: 103 IKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIP 162 I + +Q+ E L SP+IV Y + S + + ME++ GG + +L G Sbjct: 73 INKNMTHQVQAERDALALSKSPFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFD 132 Query: 163 EQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMAN- 221 E++ K V L YL +H I+HRD+KP N+L+++ G IKL DFG+S ++ N Sbjct: 133 EEMAVKYISEVALALDYLH-RHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINM 191 Query: 222 -------SFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPP 265 +F GT Y++PE L G + D W++G+ L E G IPP Sbjct: 192 MDILTTRTFCGTPDYLAPELLLGRAHGPAVDWWALGVCLFEFLTG---IPP 239 >4AF3-A nrPDB Length = 292 Score = 95.9 bits (237), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 79/300 (26%), Positives = 134/300 (44%), Gaps = 49/300 (16%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLI---HLEIKPAIRNQIIRELQVLHECN 122 DDFE LG G G V+ K S ++A K++ +E K + +Q+ RE+++ + Sbjct: 23 DDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIE-KEGVEHQLRREIEIQAHLH 81 Query: 123 SPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLRE 182 P I+ Y FY I + +E+ G L + L+K+ EQ + + L Y Sbjct: 82 HPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHG 141 Query: 183 KHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSV 242 K K++HRD+KP N+L+ +GE+K+ DFG S + GT Y+ PE ++G ++ Sbjct: 142 K-KVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNE 200 Query: 243 QSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGM 302 + D+W +G+ E+ VG PP ++ + V+ D Sbjct: 201 KVDLWCIGVLCYELLVGN---PPFESASHNETYRRIVKVDL------------------- 238 Query: 303 DSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIK 362 + P +P+G QD ++K L NP+ER L Q+ H +++ Sbjct: 239 -----------------KFPASVPTGA-----QDLISKLLRHNPSERLPLAQVSAHPWVR 276 >5ES1-A nrPDB Length = 328 Score = 95.9 bits (237), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 58/208 (27%), Positives = 106/208 (50%), Gaps = 4/208 (1%) Query: 67 DFEKISELGAGNGGVVFKVSHKPSGLVMARKLI-HLEIKPAIRNQIIRELQVLHECNSPY 125 ++ + +G GN V H +G +A K+I ++ P+ ++ RE++++ N P Sbjct: 16 NYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPN 75 Query: 126 IVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHK 185 IV + ++ + + ME+ G + L GR+ E+ ++ + Y +K+ Sbjct: 76 IVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKN- 134 Query: 186 IMHRDVKPSNILVNSRGEIKLCDFGVSGQL-IDSMANSFVGTRSYMSPERLQGTHYSV-Q 243 I+HRD+K N+L+++ IK+ DFG S + + S ++F G+ Y +PE QG Y + Sbjct: 135 IVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPE 194 Query: 244 SDIWSMGLSLVEMAVGRYPIPPPDAKEL 271 DIWS+G+ L + G P + KEL Sbjct: 195 VDIWSLGVILYTLVSGSLPFDGHNLKEL 222 >4AW2-A nrPDB Length = 437 Score = 95.5 bits (236), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 69/221 (31%), Positives = 109/221 (49%), Gaps = 12/221 (5%) Query: 54 LTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIH-LEIKPAIRNQII 112 T K K L +DFE + +G G G V V K + V A K+++ E+ Sbjct: 62 FTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACF 121 Query: 113 RELQ-VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKK-AGRIPEQILGKVS 170 RE + VL +S +I + AF D + + M++ GG L +L K R+PE++ Sbjct: 122 REERDVLVNGDSKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEEMARFYL 181 Query: 171 IAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS---MANSFVGTR 227 ++ + + + H + HRD+KP NIL++ G I+L DFG +L++ ++ VGT Sbjct: 182 AEMVIAIDSVHQLHYV-HRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTP 240 Query: 228 SYMSPERLQGT-----HYSVQSDIWSMGLSLVEMAVGRYPI 263 Y+SPE LQ Y + D WS+G+ + EM G P Sbjct: 241 DYISPEILQAMEGGKGRYGPECDWWSLGVCMYEMLYGETPF 281 >4YNZ-A nrPDB Length = 342 Score = 95.5 bits (236), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 57/201 (28%), Positives = 106/201 (52%), Gaps = 4/201 (1%) Query: 74 LGAGNGGVVFKVSHKPSGLVMARKLIHLE-IKPAIRNQIIRELQVLHECNSPYIVGFYGA 132 LG G G+V H + +A K+++ E + ++ ++ RE+ +L P+++ + Sbjct: 18 LGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHVLKLHDV 77 Query: 133 FYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVK 192 + + + + +EH+ GG L L K GR+ + K +I L + H I HRD+K Sbjct: 78 YENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFC-HSHSICHRDLK 136 Query: 193 PSNILVNSRGEIKLCDFGVSG-QLIDSMANSFVGTRSYMSPERLQGTHYS-VQSDIWSMG 250 P N+L++ R I++ DFG++ Q+ DS+ + G+ Y PE ++G Y ++D+WS G Sbjct: 137 PENLLLDERNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGRKADVWSCG 196 Query: 251 LSLVEMAVGRYPIPPPDAKEL 271 + L + VG P + ++L Sbjct: 197 VILFALLVGALPFDDDNLRQL 217 >3PPZ-A nrPDB Length = 309 Score = 95.1 bits (235), Expect = 5e-20, Method: Compositional matrix adjust. Identities = 62/202 (30%), Positives = 108/202 (53%), Gaps = 7/202 (3%) Query: 67 DFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYI 126 D ++GAG+ G V + S V + L+ + N+ +RE+ ++ P I Sbjct: 38 DLNIKEKIGAGSFGTVHRAEWHGSD-VAVKILMEQDFHAERVNEFLREVAIMKRLRHPNI 96 Query: 127 VGFYGAFYSDGEISICMEHMDGGSLDQVLKKAG---RIPEQILGKVSIAVIKGLTYLREK 183 V F GA +SI E++ GSL ++L K+G ++ E+ ++ V KG+ YL + Sbjct: 97 VLFMGAVTQPPNLSIVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAKGMNYLHNR 156 Query: 184 HK-IMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSM--ANSFVGTRSYMSPERLQGTHY 240 + I+HRD+K N+LV+ + +K+CDFG+S + + S GT +M+PE L+ Sbjct: 157 NPPIVHRDLKSPNLLVDKKYTVKVCDFGLSRLKASTFLSSKSAAGTPEWMAPEVLRDEPS 216 Query: 241 SVQSDIWSMGLSLVEMAVGRYP 262 + +SD++S G+ L E+A + P Sbjct: 217 NEKSDVYSFGVILWELATLQQP 238 >6C9D-A nrPDB Length = 459 Score = 94.7 bits (234), Expect = 6e-20, Method: Compositional matrix adjust. Identities = 57/201 (28%), Positives = 101/201 (50%), Gaps = 4/201 (1%) Query: 74 LGAGNGGVVFKVSHKPSGLVMARKLI-HLEIKPAIRNQIIRELQVLHECNSPYIVGFYGA 132 +G GN V H +G +A K+I ++ P ++ RE++++ N P IV + Sbjct: 29 IGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEV 88 Query: 133 FYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVK 192 ++ + + ME+ GG + L GR+ E+ ++ + Y +K+ I+HRD+K Sbjct: 89 IETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKY-IVHRDLK 147 Query: 193 PSNILVNSRGEIKLCDFGVSGQL-IDSMANSFVGTRSYMSPERLQGTHYSV-QSDIWSMG 250 N+L++ IK+ DFG S + + + + F G+ Y +PE QG Y + D+WS+G Sbjct: 148 AENLLLDGDMNIKIADFGFSNEFTVGNKLDEFCGSPPYAAPELFQGKKYDGPEVDVWSLG 207 Query: 251 LSLVEMAVGRYPIPPPDAKEL 271 + L + G P + KEL Sbjct: 208 VILYTLVSGSLPFDGQNLKEL 228 >4BBM-A nrPDB Length = 331 Score = 94.7 bits (234), Expect = 7e-20, Method: Compositional matrix adjust. Identities = 81/303 (26%), Positives = 135/303 (44%), Gaps = 26/303 (8%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMA-RKLIHLEIKPAIRNQIIRELQVLHECNSPYI 126 +E + +G G+ G+V K +K +G ++A +K + + ++ +RE+++L + + Sbjct: 27 YENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHENL 86 Query: 127 VGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKI 186 V + E +D LD + + Q++ K +I G+ + H I Sbjct: 87 VNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIGFCHS-HNI 145 Query: 187 MHRDVKPSNILVNSRGEIKLCDFGVSGQLI--DSMANSFVGTRSYMSPERLQG-THYSVQ 243 +HRD+KP NILV+ G +KLCDFG + L + + V TR Y +PE L G Y Sbjct: 146 IHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYDDEVATRWYRAPELLVGDVKYGKA 205 Query: 244 SDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMD 303 D+W++G + EM +G P+ P D+ +L G+ PR + + Sbjct: 206 VDVWAIGCLVTEMFMGE-PLFPGDSDIDQLYHIMMCLGNLI---PRHQEL--------FN 253 Query: 304 SRPPMAIFELLDYIVNEP----PPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHA 359 P A L + EP PKL V D KCL +P +R +L+ H Sbjct: 254 KNPVFAGVRLPEIKEREPLERRYPKLSEVVI-----DLAKKCLHIDPDKRPFCAELLHHD 308 Query: 360 FIK 362 F + Sbjct: 309 FFQ 311 >2QNJ-A nrPDB Length = 328 Score = 94.7 bits (234), Expect = 7e-20, Method: Compositional matrix adjust. Identities = 57/208 (27%), Positives = 105/208 (50%), Gaps = 4/208 (1%) Query: 67 DFEKISELGAGNGGVVFKVSHKPSGLVMARKLI-HLEIKPAIRNQIIRELQVLHECNSPY 125 ++ + +G GN V H +G +A K+I ++ P ++ RE++++ N P Sbjct: 13 NYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPN 72 Query: 126 IVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHK 185 IV + ++ + + ME+ GG + L GR+ E+ ++ + Y +K + Sbjct: 73 IVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQK-R 131 Query: 186 IMHRDVKPSNILVNSRGEIKLCDFGVSGQL-IDSMANSFVGTRSYMSPERLQGTHYSV-Q 243 I+HRD+K N+L+++ IK+ DFG S + + ++F G+ Y +PE QG Y + Sbjct: 132 IVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPE 191 Query: 244 SDIWSMGLSLVEMAVGRYPIPPPDAKEL 271 D+WS+G+ L + G P + KEL Sbjct: 192 VDVWSLGVILYTLVSGSLPFDGQNLKEL 219 >2HAK-A nrPDB Length = 328 Score = 94.7 bits (234), Expect = 7e-20, Method: Compositional matrix adjust. Identities = 57/201 (28%), Positives = 102/201 (50%), Gaps = 4/201 (1%) Query: 74 LGAGNGGVVFKVSHKPSGLVMARKLI-HLEIKPAIRNQIIRELQVLHECNSPYIVGFYGA 132 +G GN V H +G +A K+I ++ P ++ RE++++ N P IV + Sbjct: 23 IGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEV 82 Query: 133 FYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVK 192 ++ + + ME+ GG + L GR+ E+ ++ + Y +K+ I+HRD+K Sbjct: 83 IETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKY-IVHRDLK 141 Query: 193 PSNILVNSRGEIKLCDFGVSGQL-IDSMANSFVGTRSYMSPERLQGTHYSV-QSDIWSMG 250 N+L++ IK+ DFG S + + + ++F G+ Y +PE QG Y + D+WS+G Sbjct: 142 AENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG 201 Query: 251 LSLVEMAVGRYPIPPPDAKEL 271 + L + G P + KEL Sbjct: 202 VILYTLVSGSLPFDGQNLKEL 222 >6BDL-A nrPDB Length = 347 Score = 94.0 bits (232), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 63/212 (29%), Positives = 98/212 (46%), Gaps = 5/212 (2%) Query: 60 VGELKDDDFEKISELGAGNGGVVFKVSHKPS-GLVMARKLIHLEIKPAIRNQ--IIRELQ 116 LK DF I LG G G V V K A K++ R Q I E Q Sbjct: 28 FANLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQ 87 Query: 117 VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKG 176 ++ +S +IV Y F + + ME GG L +L+ G + + V++ Sbjct: 88 IMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEA 147 Query: 177 LTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL-IDSMANSFVGTRSYMSPERL 235 YL K I++RD+KP N++++ RG KL DFG + ++ +F GT Y++PE + Sbjct: 148 FAYLHSK-GIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEII 206 Query: 236 QGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPD 267 + + +D WS+G+ + E+ G P PD Sbjct: 207 LNKGHDISADYWSLGILMYELLTGSPPFSGPD 238 >4AU8-A nrPDB Length = 296 Score = 93.6 bits (231), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 80/311 (25%), Positives = 143/311 (45%), Gaps = 31/311 (9%) Query: 61 GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKP-AIRNQIIRELQVLH 119 G + +EK+ ++G G G VFK ++ + ++A K + L+ + + +RE+ +L Sbjct: 1 GAMGSQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLK 60 Query: 120 ECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKA-----GRIPEQILGKVSIAVI 174 E IV + +SD ++++ E D Q LKK G + +I+ ++ Sbjct: 61 ELKHKNIVRLHDVLHSDKKLTLVFEFCD-----QDLKKYFDSCNGDLDPEIVKSFLFQLL 115 Query: 175 KGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVS---GQLIDSMANSFVGTRSYMS 231 KGL + ++ ++HRD+KP N+L+N GE+KL DFG++ G + + V T Y Sbjct: 116 KGLGFCHSRN-VLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVV-TLWYRP 173 Query: 232 PERLQGTH-YSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRP 290 P+ L G YS D+WS G E+A P+ P + + +L ++ G TP Sbjct: 174 PDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLG----TPTEE 229 Query: 291 RTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERA 350 + P S + P ++ +VN P +G +D + L NP +R Sbjct: 230 QWP----SMTKLPDYKPYPMYPATTSLVNVVPKLNATG------RDLLQNLLKCNPVQRI 279 Query: 351 DLKQLMVHAFI 361 ++ + H + Sbjct: 280 SAEEALQHPYF 290 >3ORZ-A nrPDB Length = 316 Score = 93.2 bits (230), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 65/218 (29%), Positives = 102/218 (46%), Gaps = 14/218 (6%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQ----IIRELQVLHEC 121 +DF+ LG G+ V + A K+ LE + I+ + RE V+ Sbjct: 37 EDFKFGKILGEGSFSTVVLARELATSREYAIKI--LEKRHIIKENKVPYVTRERDVMSRL 94 Query: 122 NSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLR 181 + P+ V Y F D ++ + + G L + ++K G E + ++ L YL Sbjct: 95 DHPFFVKLYFCFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLH 154 Query: 182 EKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLI----DSMANSFVGTRSYMSPERLQG 237 K I+HRD+KP NIL+N I++ DFG + L + ANSFVGT Y+SPE L Sbjct: 155 GK-GIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTE 213 Query: 238 THYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMF 275 SD+W++G + ++ G +PP A L+F Sbjct: 214 KSACKSSDLWALGCIIYQLVAG---LPPFRAGNEYLIF 248 >3HDN-A nrPDB Length = 373 Score = 92.8 bits (229), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 62/213 (29%), Positives = 104/213 (48%), Gaps = 6/213 (2%) Query: 64 KDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE--IKPAIRNQIIRELQVL-HE 120 K DF + +G G+ G V HK + A K++ + +K I+ E VL Sbjct: 36 KPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKN 95 Query: 121 CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL 180 P++VG + +F + ++ +++++GG L L++ E + + L YL Sbjct: 96 VKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYL 155 Query: 181 REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLI--DSMANSFVGTRSYMSPERLQGT 238 + I++RD+KP NIL++S+G I L DFG+ + I +S ++F GT Y++PE L Sbjct: 156 HSLN-IVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQ 214 Query: 239 HYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKEL 271 Y D W +G L EM G P + E+ Sbjct: 215 PYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEM 247 >3OHT-A nrPDB Length = 389 Score = 92.4 bits (228), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 78/306 (25%), Positives = 136/306 (44%), Gaps = 29/306 (9%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIR-NQIIRELQVLHECNSPYI 126 ++ +S +G+G G V SGL +A K + + I + REL++L + Sbjct: 53 YQTLSPVGSGAYGSVCSSYDVKSGLKIAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENV 112 Query: 127 VGFYGAFYSDGEIS-----ICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLR 181 +G F + + H+ G L+ ++K ++ + + + +++GL Y+ Sbjct: 113 IGLLDVFTPATSLEEFNDVYLVTHLMGADLNNIVK-CQKLTDDHVQFLIYQILRGLKYIH 171 Query: 182 EKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPE-RLQGTHY 240 I+HRD+KPSN+ VN E+K+ DFG++ D M +V TR Y +PE L HY Sbjct: 172 SA-DIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTG-YVATRWYRAPEIMLNWMHY 229 Query: 241 SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPR---PRTPGRPL 297 ++ DIWS+G + E+ GR P D +L ++ G TPP R P Sbjct: 230 NMTVDIWSVGCIMAELLTGRTLFPGTDHIN-QLQQIMRLTG----TPPASVISRMPSHEA 284 Query: 298 SSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMV 357 +Y ++S P M D + P + D + K L+ + +R + + Sbjct: 285 RNY-INSLPQMPKRNFADVFIGANPLAV----------DLLEKMLVLDTDKRITASEALA 333 Query: 358 HAFIKR 363 H + + Sbjct: 334 HPYFSQ 339 >3UC3-A nrPDB Length = 361 Score = 92.0 bits (227), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 64/206 (31%), Positives = 105/206 (50%), Gaps = 7/206 (3%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPY 125 D ++ + ++G+GN GV + K + ++A K ++E AI + RE+ P Sbjct: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVK--YIERGAAIDENVQREIINHRSLRHPN 77 Query: 126 IVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHK 185 IV F + ++I ME+ GG L + + AGR E ++ G++Y + Sbjct: 78 IVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYC-HSMQ 136 Query: 186 IMHRDVKPSNILVNSR--GEIKLCDFGVS-GQLIDSMANSFVGTRSYMSPERLQGTHYSV 242 I HRD+K N L++ +K+CDFG S ++ S S VGT +Y++PE L Y Sbjct: 137 ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDG 196 Query: 243 Q-SDIWSMGLSLVEMAVGRYPIPPPD 267 + +D+WS G++L M VG YP P+ Sbjct: 197 KIADVWSCGVTLYVMLVGAYPFEDPE 222 >4IDT-A nrPDB Length = 356 Score = 92.0 bits (227), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 65/197 (32%), Positives = 100/197 (50%), Gaps = 15/197 (7%) Query: 74 LGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAF 133 LG G+ G V ++ K +G A K + LE+ A EL SP IV YGA Sbjct: 82 LGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRA------EELMACAGLTSPRIVPLYGAV 135 Query: 134 YSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKP 193 ++I ME ++GGSL Q++K+ G +PE ++GL YL + +I+H DVK Sbjct: 136 REGPWVNIFMELLEGGSLGQLVKEQGCLPEDRALYYLGQALEGLEYLHSR-RILHGDVKA 194 Query: 194 SNILVNSRG-EIKLCDFGVS------GQLIDSMANSFV-GTRSYMSPERLQGTHYSVQSD 245 N+L++S G LCDFG + G D + ++ GT ++M+PE + G + D Sbjct: 195 DNVLLSSDGSHAALCDFGHAVCLQPDGLGKDLLTGDYIPGTETHMAPEVVLGRSCDAKVD 254 Query: 246 IWSMGLSLVEMAVGRYP 262 +WS ++ M G +P Sbjct: 255 VWSSCCMMLHMLNGCHP 271 >4JXF-A nrPDB Length = 266 Score = 92.0 bits (227), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 78/310 (25%), Positives = 139/310 (44%), Gaps = 51/310 (16%) Query: 60 VGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE--IKPAIRNQIIRELQV 117 +GE K +DF+ + LG G+ V++ +GL +A K+I + K + ++ E+++ Sbjct: 2 IGE-KIEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKI 60 Query: 118 LHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR-IPEQILGKVSIAVIKG 176 + P I+ Y F + + +E G +++ LK + E +I G Sbjct: 61 HCQLKHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITG 120 Query: 177 LTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLI--DSMANSFVGTRSYMSPER 234 + YL H I+HRD+ SN+L+ IK+ DFG++ QL + GT +Y+SPE Sbjct: 121 MLYL-HSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEI 179 Query: 235 LQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPG 294 + + ++SD+WS+G + +GR PP D ++ V Sbjct: 180 ATRSAHGLESDVWSLGCMFYTLLIGR---PPFDTDTVKNTLNKVV--------------- 221 Query: 295 RPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQ 354 L DY ++PS S+E +D +++ L +NPA+R L Sbjct: 222 ------------------LADY-------EMPS-FLSIEAKDLIHQLLRRNPADRLSLSS 255 Query: 355 LMVHAFIKRS 364 ++ H F+ R+ Sbjct: 256 VLDHPFMSRN 265 >3MN3-A nrPDB Length = 271 Score = 91.7 bits (226), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 64/232 (27%), Positives = 119/232 (51%), Gaps = 11/232 (4%) Query: 67 DFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEI--KPAIRNQIIRELQVLHECNSP 124 +++ + LG G+ G V H +G +A K+I+ ++ K ++ +I RE+ L P Sbjct: 5 NYQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRHP 64 Query: 125 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKH 184 +I+ Y S EI + +E+ D ++++ ++ EQ + +I + Y +H Sbjct: 65 HIIKLYDVIKSKDEIIMVIEYAGNELFDYIVQR-DKMSEQEARRFFQQIISAVEYC-HRH 122 Query: 185 KIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID-SMANSFVGTRSYMSPERLQGTHYSV- 242 KI+HRD+KP N+L++ +K+ DFG+S + D + + G+ +Y +PE + G Y+ Sbjct: 123 KIVHRDLKPENLLLDEHLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKLYAGP 182 Query: 243 QSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPG 294 + D+WS G+ L M R P D + + ++F G T P+ +PG Sbjct: 183 EVDVWSCGVILYVMLCRRLPF---DDESIPVLFKNISNG--VYTLPKFLSPG 229 >4REW-A nrPDB Length = 540 Score = 91.3 bits (225), Expect = 6e-19, Method: Compositional matrix adjust. Identities = 59/197 (29%), Positives = 104/197 (52%), Gaps = 11/197 (5%) Query: 74 LGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRN-----QIIRELQVLHECNSPYIVG 128 LG G G V H+ +G +A K+++ + IR+ +I RE+Q L P+I+ Sbjct: 14 LGVGTFGKVKVGKHELTGHKVAVKILN---RQKIRSLDVVGKIRREIQNLKLFRHPHIIK 70 Query: 129 FYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMH 188 Y + +I + ME++ GG L + K GR+ E+ ++ ++ G+ Y +H ++H Sbjct: 71 LYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYC-HRHMVVH 129 Query: 189 RDVKPSNILVNSRGEIKLCDFGVSGQLID-SMANSFVGTRSYMSPERLQGTHYS-VQSDI 246 RD+KP N+L+++ K+ DFG+S + D + G+ +Y +PE + G Y+ + DI Sbjct: 130 RDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDI 189 Query: 247 WSMGLSLVEMAVGRYPI 263 WS G+ L + G P Sbjct: 190 WSSGVILYALLCGTLPF 206 >4GS6-A nrPDB Length = 315 Score = 91.3 bits (225), Expect = 6e-19, Method: Compositional matrix adjust. Identities = 80/305 (26%), Positives = 136/305 (44%), Gaps = 58/305 (19%) Query: 61 GELKDDDFEKISE---LGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQV 117 G L D+++I +G G GVV K + + A K I E + R I EL+ Sbjct: 1 GSLHMIDYKEIEVEEVVGRGAFGVVCKAKWRAKDV--AIKQIESESE---RKAFIVELRQ 55 Query: 118 LHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKV---SIAVI 174 L N P IV YGA + + + ME+ +GGSL VL A +P + Sbjct: 56 LSRVNHPNIVKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCS 113 Query: 175 KGLTYLR--EKHKIMHRDVKPSNILVNSRGEI-KLCDFGVSGQLIDSMANSFVGTRSYMS 231 +G+ YL + ++HRD+KP N+L+ + G + K+CDFG + + M N+ G+ ++M+ Sbjct: 114 QGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNN-KGSAAWMA 172 Query: 232 PERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPR 291 PE +G++YS + D++S G+ L E+ R P +M+ Sbjct: 173 PEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVH------------- 219 Query: 292 TPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERAD 351 +RPP+ I N P P + + +C K+P++R Sbjct: 220 ----------NGTRPPL--------IKNLPKP----------IESLMTRCWSKDPSQRPS 251 Query: 352 LKQLM 356 +++++ Sbjct: 252 MEEIV 256 >4CFH-A nrPDB Length = 493 Score = 91.3 bits (225), Expect = 6e-19, Method: Compositional matrix adjust. Identities = 64/218 (29%), Positives = 113/218 (51%), Gaps = 12/218 (5%) Query: 54 LTQKQKV-GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRN--- 109 + +KQK G +K + LG G G V H+ +G +A K+++ + IR+ Sbjct: 20 MAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILN---RQKIRSLDV 76 Query: 110 --QIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILG 167 +I RE+Q L P+I+ Y + +I + ME++ GG L + K GR+ E+ Sbjct: 77 VGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESR 136 Query: 168 KVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID-SMANSFVGT 226 ++ ++ G+ Y +H ++HRD+KP N+L+++ K+ DFG+S + D + G+ Sbjct: 137 RLFQQILSGVDYC-HRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGS 195 Query: 227 RSYMSPERLQGTHYS-VQSDIWSMGLSLVEMAVGRYPI 263 +Y +PE + G Y+ + DIWS G+ L + G P Sbjct: 196 PNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPF 233 >3ZUT-A nrPDB Length = 362 Score = 91.3 bits (225), Expect = 7e-19, Method: Compositional matrix adjust. Identities = 65/208 (31%), Positives = 105/208 (50%), Gaps = 11/208 (5%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHL--EIKPAIRNQIIRELQVLHECNS 123 D +E + ++G+GN GV + K S ++A K I +I ++ +II + H Sbjct: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRH---- 74 Query: 124 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREK 183 P IV F + ++I ME+ GG L + + AGR E +I G++Y Sbjct: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAM 134 Query: 184 HKIMHRDVKPSNILVNSRG--EIKLCDFGVS-GQLIDSMANSFVGTRSYMSPERLQGTHY 240 ++ HRD+K N L++ +K+C FG S ++ S S VGT +Y++PE L Y Sbjct: 135 -QVCHRDLKLENTLLDGSPAPRLKICAFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEY 193 Query: 241 SVQ-SDIWSMGLSLVEMAVGRYPIPPPD 267 + +D+WS G++L M VG YP P+ Sbjct: 194 DGKVADVWSCGVTLYVMLVGAYPFEDPE 221 >4RED-A nrPDB Length = 351 Score = 91.3 bits (225), Expect = 7e-19, Method: Compositional matrix adjust. Identities = 59/197 (29%), Positives = 104/197 (52%), Gaps = 11/197 (5%) Query: 74 LGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRN-----QIIRELQVLHECNSPYIVG 128 LG G G V H+ +G +A K+++ + IR+ +I RE+Q L P+I+ Sbjct: 22 LGVGTFGKVKVGKHELTGHAVAVKILN---RQKIRSLDVVGKIRREIQNLKLFRHPHIIK 78 Query: 129 FYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMH 188 Y + +I + ME++ GG L + K GR+ E+ ++ ++ G+ Y +H ++H Sbjct: 79 LYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYC-HRHMVVH 137 Query: 189 RDVKPSNILVNSRGEIKLCDFGVSGQLID-SMANSFVGTRSYMSPERLQGTHYSV-QSDI 246 RD+KP N+L+++ K+ DFG+S + D + G+ +Y +PE + G Y+ + DI Sbjct: 138 RDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDI 197 Query: 247 WSMGLSLVEMAVGRYPI 263 WS G+ L + G P Sbjct: 198 WSSGVILYALLCGTLPF 214 >5KZ7-A nrPDB Length = 346 Score = 90.9 bits (224), Expect = 8e-19, Method: Compositional matrix adjust. Identities = 56/208 (26%), Positives = 104/208 (50%), Gaps = 4/208 (1%) Query: 67 DFEKISELGAGNGGVVFKVSHKPSGLVMARKLI-HLEIKPAIRNQIIRELQVLHECNSPY 125 ++ + +G GN V H +G +A K+I ++ + ++ RE++++ N P Sbjct: 34 NYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPN 93 Query: 126 IVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHK 185 IV + ++ + + ME+ GG + L GR+ E+ ++ + Y +K Sbjct: 94 IVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKF- 152 Query: 186 IMHRDVKPSNILVNSRGEIKLCDFGVSGQL-IDSMANSFVGTRSYMSPERLQGTHYSV-Q 243 I+HRD+K N+L+++ IK+ DFG S + + ++F G+ Y +PE QG Y + Sbjct: 153 IVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPE 212 Query: 244 SDIWSMGLSLVEMAVGRYPIPPPDAKEL 271 D+WS+G+ L + G P + KEL Sbjct: 213 VDVWSLGVILYTLVSGSLPFDGQNLKEL 240 >1G3N-A nrPDB Length = 326 Score = 90.9 bits (224), Expect = 9e-19, Method: Compositional matrix adjust. Identities = 86/311 (27%), Positives = 140/311 (45%), Gaps = 32/311 (10%) Query: 65 DDDFEKISELGAGNGGVVFKVSH-KPSGLVMARKLIHLEI-KPAIRNQIIRELQVLHECN 122 D +E ++E+G G G VFK K G +A K + ++ + + IRE+ VL Sbjct: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLE 69 Query: 123 S---PYIVGFYGAFY-----SDGEISICMEHMDGGSLDQVLKKAGR--IPEQILGKVSIA 172 + P +V + + ++++ EH+D L L K +P + + + Sbjct: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQ 128 Query: 173 VIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA-NSFVGTRSYMS 231 +++GL +L H+++HRD+KP NILV S G+IKL DFG++ MA S V T Y + Sbjct: 129 LLRGLDFL-HSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRA 187 Query: 232 PERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPR 291 PE L + Y+ D+WS+G EM R P+ + +L V G E PR Sbjct: 188 PEVLLQSSYATPVDLWSVGCIFAEM-FRRKPLFRGSSDVDQLGKILDVIGLPGE-EDWPR 245 Query: 292 TPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERAD 351 P ++ S P+ K + + L +D + KCL NPA+R Sbjct: 246 DVALPRQAFHSKSAQPIE--------------KFVTDIDELG-KDLLLKCLTFNPAKRIS 290 Query: 352 LKQLMVHAFIK 362 + H + + Sbjct: 291 AYSALSHPYFQ 301 >3UDB-A nrPDB Length = 317 Score = 90.5 bits (223), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 65/208 (31%), Positives = 105/208 (50%), Gaps = 11/208 (5%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHL--EIKPAIRNQIIRELQVLHECNS 123 D +E + ++GAGN GV + K + ++A K I +I ++ +II + H Sbjct: 19 DRYELVKDIGAGNFGVARLMRDKQANELVAVKYIERGEKIDENVKREIINHRSLRH---- 74 Query: 124 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREK 183 P IV F + ++I ME+ GG L + + AGR E +I G++Y Sbjct: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYAHAM 134 Query: 184 HKIMHRDVKPSNILVNSRG--EIKLCDFGVS-GQLIDSMANSFVGTRSYMSPERLQGTHY 240 ++ HRD+K N L++ +K+ DFG S ++ S S VGT +Y++PE L Y Sbjct: 135 -QVAHRDLKLENTLLDGSPAPRLKIADFGYSKASVLHSQPKSAVGTPAYIAPEVLLKKEY 193 Query: 241 SVQ-SDIWSMGLSLVEMAVGRYPIPPPD 267 + +D+WS G++L M VG YP P+ Sbjct: 194 DGKVADVWSCGVTLYVMLVGAYPFEDPE 221 >4EWQ-A nrPDB Length = 383 Score = 90.1 bits (222), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 59/207 (28%), Positives = 101/207 (48%), Gaps = 10/207 (4%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIR-NQIIRELQVLHECNSPYI 126 ++ +S +G+G G V +GL +A K + + I + REL++L + Sbjct: 47 YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENV 106 Query: 127 VGFYGAFYSDGEIS-----ICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLR 181 +G F + + H+ G L+ ++K ++ + + + +++GL Y+ Sbjct: 107 IGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVK-CQKLTDDHVQFLIYQILRGLKYIH 165 Query: 182 EKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPE-RLQGTHY 240 I+HRD+KPSN+ VN E+K+ DFG++ D M +V TR Y +PE L HY Sbjct: 166 SA-DIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT-GYVATRWYRAPEIMLNWMHY 223 Query: 241 SVQSDIWSMGLSLVEMAVGRYPIPPPD 267 + DIWS+G + E+ GR P D Sbjct: 224 NQTVDIWSVGCIMAELLTGRTLFPGTD 250 >3TXO-A nrPDB Length = 353 Score = 90.1 bits (222), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 62/211 (29%), Positives = 104/211 (49%), Gaps = 6/211 (2%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEI--KPAIRNQIIRELQVLHEC-N 122 D+FE I LG G+ G V K +G + A K++ ++ + + E ++L N Sbjct: 23 DNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARN 82 Query: 123 SPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLRE 182 P++ + F + + ME ++GG L ++K+ R E + +I L +L + Sbjct: 83 HPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHD 142 Query: 183 KHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS--MANSFVGTRSYMSPERLQGTHY 240 K I++RD+K N+L++ G KL DFG+ + I + +F GT Y++PE LQ Y Sbjct: 143 K-GIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLY 201 Query: 241 SVQSDIWSMGLSLVEMAVGRYPIPPPDAKEL 271 D W+MG+ L EM G P + +L Sbjct: 202 GPAVDWWAMGVLLYEMLCGHAPFEAENEDDL 232 >4UY9-A nrPDB Length = 323 Score = 89.7 bits (221), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 72/262 (27%), Positives = 124/262 (47%), Gaps = 22/262 (8%) Query: 61 GELKDDDFEKISE---LGAGNGGVVFKVSHKPSGLVM--ARKLIHLEIKPAIRNQIIREL 115 G+L + DF +++ +G G G V++ + + AR +I I N + +E Sbjct: 1 GQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIEN-VRQEA 59 Query: 116 QVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIK 175 ++ P I+ G + + + ME GG L++VL RIP IL ++ + + Sbjct: 60 KLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLS-GKRIPPDILVNWAVQIAR 118 Query: 176 GLTYLREKH--KIMHRDVKPSNILVNSRGE--------IKLCDFGVSGQLIDSMANSFVG 225 G+ YL ++ I+HRD+K SNIL+ + E +K+ DFG++ + + S G Sbjct: 119 GMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAG 178 Query: 226 TRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAE 285 T ++M+PE ++ + +S SD+WS G+ L E+ G P D L + +G + A Sbjct: 179 TYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDG--LAVAYGVAMNKLAL- 235 Query: 286 TPPRPRTPGRPLSSYGMDSRPP 307 P P T P + D P Sbjct: 236 --PIPSTCPEPFAKLMEDCWNP 255 >4G3E-A nrPDB Length = 352 Score = 89.4 bits (220), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 66/197 (33%), Positives = 102/197 (51%), Gaps = 15/197 (7%) Query: 74 LGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAF 133 +G G+ G V ++ K +G A K + LE+ R + EL +SP IV YGA Sbjct: 82 VGRGSFGEVHRMKDKQTGFQCAVKKVRLEV---FR---VEELVACAGLSSPRIVPLYGAV 135 Query: 134 YSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKP 193 ++I ME ++GGSL Q++K+ G +PE ++GL YL + +I+H DVK Sbjct: 136 REGPWVNIFMELLEGGSLGQLIKQMGCLPEDRALYYLGQALEGLEYLHTR-RILHGDVKA 194 Query: 194 SNILVNSRG-EIKLCDFGVSGQLI-DSMANSFV------GTRSYMSPERLQGTHYSVQSD 245 N+L++S G LCDFG + L D + S + GT ++M+PE + G + D Sbjct: 195 DNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAPEVVMGKPCDAKVD 254 Query: 246 IWSMGLSLVEMAVGRYP 262 IWS ++ M G +P Sbjct: 255 IWSSCCMMLHMLNGCHP 271 >4WNO-A nrPDB Length = 287 Score = 89.4 bits (220), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 64/241 (26%), Positives = 111/241 (46%), Gaps = 16/241 (6%) Query: 67 DFEKISELGAGNGGVVFKVSHKPS-GLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPY 125 +F + +G G VVFK H+ + L +A K I+ + + + +E+++L E Sbjct: 19 EFSRKDLIGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHEN 78 Query: 126 IVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHK 185 IV Y + + ME+ +GG L L + E + ++ + I G L Sbjct: 79 IVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTI-RLFLQQIAGAMRLLHSKG 137 Query: 186 IMHRDVKPSNILVNSRG---------EIKLCDFGVSGQL-IDSMANSFVGTRSYMSPERL 235 I+HRD+KP NIL+++ +K+ DFG + L + MA + G+ YM+PE + Sbjct: 138 IIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVI 197 Query: 236 QGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGR 295 HY ++D+WS+G + + G+ P ++L L + E + P PR Sbjct: 198 MSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFY----EKNKTLVPTIPRETSA 253 Query: 296 P 296 P Sbjct: 254 P 254 >3NCG-A nrPDB Length = 486 Score = 89.4 bits (220), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 64/199 (32%), Positives = 105/199 (52%), Gaps = 15/199 (7%) Query: 74 LGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQ----IIRELQVLHECNSPYIVGF 129 LG G+ G V K + + A K+I+ K + +N+ I+RE+++L + + P I+ Sbjct: 30 LGKGSFGEVLKCKDRITQQEYAVKVIN---KASAKNKDTSTILREVELLKKLDHPNIMKL 86 Query: 130 YGAFYSDGEISICMEHMDGGSL-DQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMH 188 + I E GG L D+++K+ R E ++ V G+TY+ KH I+H Sbjct: 87 FEILEDSSSFYIVGELYTGGELFDEIIKRK-RFSEHDAARIIKQVFSGITYMH-KHNIVH 144 Query: 189 RDVKPSNILVNSR---GEIKLCDFGVSGQL-IDSMANSFVGTRSYMSPERLQGTHYSVQS 244 RD+KP NIL+ S+ +IK+ DFG+S ++ +GT Y++PE L+GT Y + Sbjct: 145 RDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVLRGT-YDEKC 203 Query: 245 DIWSMGLSLVEMAVGRYPI 263 D+WS G+ L + G P Sbjct: 204 DVWSAGVILYILLSGTPPF 222 >4OTD-A nrPDB Length = 341 Score = 89.0 bits (219), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 66/217 (30%), Positives = 109/217 (50%), Gaps = 11/217 (5%) Query: 63 LKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIH---LEIKPAIRNQII--RELQV 117 L +DF+ ++ LG G+ G V +PSG + A K + + + + + + R L Sbjct: 9 LTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAA 68 Query: 118 LHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLD-QVLKKAGRIPEQILGKVSIAVIKG 176 + P++V +G F + + ME+ GG L + P I S V+ G Sbjct: 69 VTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSDVFSEPRAIF--YSACVVLG 126 Query: 177 LTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVS--GQLIDSMANSFVGTRSYMSPER 234 L +L E HKI++RD+K N+L+++ G +K+ DFG+ G ++F GT +++PE Sbjct: 127 LQFLHE-HKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEV 185 Query: 235 LQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKEL 271 L T Y+ D W +G+ L EM VG P P D +E+ Sbjct: 186 LTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEV 222 >4C0T-A nrPDB Length = 974 Score = 89.0 bits (219), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 86/381 (22%), Positives = 155/381 (40%), Gaps = 67/381 (17%) Query: 17 GSAVNGTSSAETNLEALQ-KKLEELELDEQQ-RKRLEAFLTQKQKVGELKD-----DDFE 69 + V+ T E N + + K E L+ +E+ K+ A T K GE+K DF+ Sbjct: 210 NNTVDNTEEEENNDDTDEIPKSETLKQNEENWEKKGAAVKTIKTMDGEMKTIRRNVTDFK 269 Query: 70 KISELGAGNGGVVFKVSHKPSGLVMARKLI---HLEIKPAIRNQIIRELQVLHECNSPYI 126 ELG G+ V + K +G A K++ H+ + ++ I + + N + Sbjct: 270 FGKELGEGSYSTVILATDKITGKQYAVKVLDKRHIIKEKKVKYVNIEKHALNRLSNRLGV 329 Query: 127 VGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKI 186 + Y F + +++ G L ++K+ + E+ ++ + Y+ + + + Sbjct: 330 ISLYFTFQDKDSLYFVLDYASNGELLTLIKRYNTLNEECTRHFGAQILDAIKYMHD-NGV 388 Query: 187 MHRDVKPSNILVNSRGEIKLCDFGVSGQL-----------IDSMANSFVGTRSYMSPERL 235 +HRD+KP NIL++ + I++ DFG + L +D A SFVGT Y+SPE L Sbjct: 389 IHRDLKPENILLDDKMRIQITDFGTARLLEKKNDESEEYPVDVRAKSFVGTAEYVSPELL 448 Query: 236 QGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGR 295 + + D+W+ G + +M G+ PP A L F + Sbjct: 449 ENKYCGKPGDVWAFGCIIYQMIAGK---PPFKATNEYLTFQKITK--------------- 490 Query: 296 PLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQL 355 L + S F +D + K L+ P+ RA + ++ Sbjct: 491 ------------------LQFAF--------SAGFPTIIRDLIKKILVLQPSRRATIPEI 524 Query: 356 MVHAFIKRSDAEEVDFAGWLC 376 H F + D ++ D + WL Sbjct: 525 QKHYFFQSVDFKDFD-SIWLS 544 >4CFF-A nrPDB Length = 571 Score = 88.6 bits (218), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 62/218 (28%), Positives = 110/218 (50%), Gaps = 12/218 (5%) Query: 54 LTQKQKV-GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRN--- 109 + +KQK G +K + LG G G V H+ +G +A K+++ + IR+ Sbjct: 20 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILN---RQKIRSLDV 76 Query: 110 --QIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILG 167 +I RE+Q L P+I+ Y + + + ME++ GG L + K GR+ E Sbjct: 77 VGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEAR 136 Query: 168 KVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID-SMANSFVGT 226 ++ ++ + Y +H ++HRD+KP N+L+++ K+ DFG+S + D + G+ Sbjct: 137 RLFQQILSAVDYC-HRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGS 195 Query: 227 RSYMSPERLQGTHYS-VQSDIWSMGLSLVEMAVGRYPI 263 +Y +PE + G Y+ + DIWS G+ L + G P Sbjct: 196 PNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPF 233 >1VZO-A nrPDB Length = 355 Score = 88.6 bits (218), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 65/212 (30%), Positives = 110/212 (51%), Gaps = 17/212 (8%) Query: 66 DDFEKISELGAGNGGVVF---KVSHKPSGLVMARKLIH---LEIKPAIRNQIIRELQVL- 118 ++FE + LG G G VF K+S +G + A K++ + K E QVL Sbjct: 54 ENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLE 113 Query: 119 HECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLT 178 H SP++V + AF ++ ++ + +++++GG L L + R E +V I V + + Sbjct: 114 HIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEH---EVQIYVGEIVL 170 Query: 179 YLREKHK--IMHRDVKPSNILVNSRGEIKLCDFGVSGQLI---DSMANSFVGTRSYMSPE 233 L HK I++RD+K NIL++S G + L DFG+S + + A F GT YM+P+ Sbjct: 171 ALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYDFCGTIEYMAPD 230 Query: 234 RLQG--THYSVQSDIWSMGLSLVEMAVGRYPI 263 ++G + + D WS+G+ + E+ G P Sbjct: 231 IVRGGDSGHDKAVDWWSLGVLMYELLTGASPF 262 >3DFA-A nrPDB Length = 286 Score = 88.6 bits (218), Expect = 5e-18, Method: Compositional matrix adjust. Identities = 81/303 (26%), Positives = 136/303 (44%), Gaps = 55/303 (18%) Query: 74 LGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQ----IIRELQVLHECNSPYIVGF 129 LG G+ G V K + + A K+I+ K + +N+ I+RE+++L + + P I+ Sbjct: 30 LGKGSFGEVLKCKDRITQQEYAVKVIN---KASAKNKDTSTILREVELLKKLDHPNIMKL 86 Query: 130 YGAFYSDGEISICMEHMDGGSL-DQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMH 188 + I E GG L D+++K+ R E ++ V G+TY+ KH I+H Sbjct: 87 FEILEDSSSFYIVGELYTGGELFDEIIKRK-RFSEHDAARIIKQVFSGITYM-HKHNIVH 144 Query: 189 RDVKPSNILVNSR---GEIKLCDFGVSGQL-IDSMANSFVGTRSYMSPERLQGTHYSVQS 244 RD+KP NIL+ S+ +IK+ DFG+S ++ +GT Y++PE L+GT Y + Sbjct: 145 RDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVLRGT-YDEKC 203 Query: 245 DIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDS 304 D+WS G+ L + G TPP YG + Sbjct: 204 DVWSAGVILYILLSG--------------------------TPP----------FYGKNE 227 Query: 305 RPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRS 364 + E Y + P + S + +D + K L +P+ R Q + H +I++ Sbjct: 228 YDILKRVETGKYAFDLPQWRTISD----DAKDLIRKMLTFHPSLRITATQCLEHPWIQKY 283 Query: 365 DAE 367 +E Sbjct: 284 SSE 286 >3TKU-A nrPDB Length = 433 Score = 88.2 bits (217), Expect = 5e-18, Method: Compositional matrix adjust. Identities = 65/221 (29%), Positives = 107/221 (48%), Gaps = 12/221 (5%) Query: 54 LTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIH-LEIKPAIRNQII 112 TQ K +L +DFE I +G G G V V K + + A K+++ E+ Sbjct: 78 FTQLVKEMQLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACF 137 Query: 113 RELQ-VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKK-AGRIPEQILGKVS 170 RE + VL + +I + AF + + + M++ GG L +L K ++PE + Sbjct: 138 REERDVLVNGDCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYI 197 Query: 171 IAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS---MANSFVGTR 227 ++ + + + H + HRD+KP N+L++ G I+L DFG ++ D ++ VGT Sbjct: 198 GEMVLAIDSIHQLHYV-HRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTP 256 Query: 228 SYMSPERLQGTH-----YSVQSDIWSMGLSLVEMAVGRYPI 263 Y+SPE LQ Y + D WS+G+ + EM G P Sbjct: 257 DYISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPF 297 >4NEU-A nrPDB Length = 333 Score = 87.8 bits (216), Expect = 7e-18, Method: Compositional matrix adjust. Identities = 58/220 (26%), Positives = 108/220 (49%), Gaps = 18/220 (8%) Query: 60 VGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLH 119 V ++K DF + +EL +G G V H+ GL++ + + ++ E ++++ Sbjct: 18 VIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMN 77 Query: 120 ECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTY 179 +V G +G+ S+ ME+M+ G+L VLK P + G++ + +I+G+ Y Sbjct: 78 RLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCY 137 Query: 180 LREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSG---------------QLIDSMANSFV 224 L K ++H+D+KP NILV++ IK+ D G++ + +D A Sbjct: 138 LHGK-GVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNG 196 Query: 225 GTRSYMSPERLQGTHY--SVQSDIWSMGLSLVEMAVGRYP 262 GT YM+PE L + + +SD++S + L + + P Sbjct: 197 GTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEP 236 >6CTH-A nrPDB Length = 309 Score = 87.8 bits (216), Expect = 7e-18, Method: Compositional matrix adjust. Identities = 61/206 (29%), Positives = 104/206 (50%), Gaps = 9/206 (4%) Query: 67 DFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYI 126 +F ++LG G G V++ + S +A K + K I+ + E++++ + Sbjct: 16 NFNAENKLGEGGFGSVYRGFLRDSDTYIAVKKVSRASKQGIK-EYASEVKIISRLRHKNL 74 Query: 127 VGFYGAFYSDGEISICMEHMDGGSLD-QVLKKAGRIPEQILGKVSIAVIKGLTYLREK-- 183 V G + GE+ + E M GSLD + K + ++ ++ + L YL E+ Sbjct: 75 VKLIGWCHERGELMLVYEFMANGSLDSHIFKGKSLLTWEVRYRIVKDLASALLYLHEEGD 134 Query: 184 HKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA----NSFVGTRSYMSPERLQGTH 239 H ++HRD+K SNI+++S KL DFG++ +L+D GT YM+PE L Sbjct: 135 HCVLHRDIKTSNIMLDSSFNAKLGDFGLA-RLVDHAKGLKKTLLAGTVGYMAPECLSSGK 193 Query: 240 YSVQSDIWSMGLSLVEMAVGRYPIPP 265 S +SD++S G+ +E+A GR I P Sbjct: 194 ASKESDVYSFGVVALEIASGRRSIEP 219 >4TPT-A nrPDB Length = 303 Score = 87.8 bits (216), Expect = 8e-18, Method: Compositional matrix adjust. Identities = 60/229 (26%), Positives = 101/229 (44%), Gaps = 26/229 (11%) Query: 74 LGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAF 133 LG G G KV+HK +G VM K + + + + E++V+ + P ++ F G Sbjct: 8 LGKGFFGQAIKVTHKATGKVMVMKEL-IRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVL 66 Query: 134 YSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKP 193 Y D ++++ E+++GG+L L+ P Q + + + G+ YL I+HRD+ Sbjct: 67 YKDKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMAYLHSMC-IIHRDLNS 125 Query: 194 SNILVNSRGEIKLCDFGVSGQLIDSMAN----------------------SFVGTRSYMS 231 N L+ + + DFG+S +++ + VG +M+ Sbjct: 126 HNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGNPYWMA 185 Query: 232 PERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVE 280 PE L G Y DI+S G+ L E+ Y PD L FG V+ Sbjct: 186 PEMLNGKSYDETVDIFSFGIVLCEIIGQVY--ADPDCLPRTLDFGLNVK 232 >3H4J-B nrPDB Length = 336 Score = 87.4 bits (215), Expect = 9e-18, Method: Compositional matrix adjust. Identities = 57/194 (29%), Positives = 101/194 (52%), Gaps = 6/194 (3%) Query: 74 LGAGNGGVVFKVSHKPSGLVMARKLIHLEI--KPAIRNQIIRELQVLHECNSPYIVGFYG 131 LG G+ G V +H + +A K I ++ K + ++ RE+ L P+I+ Y Sbjct: 17 LGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREISYLKLLRHPHIIKLYD 76 Query: 132 AFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDV 191 + +I + +E+ G D +++K R+ E + +I + Y +HKI+HRD+ Sbjct: 77 VITTPTDIVMVIEYAGGELFDYIVEKK-RMTEDEGRRFFQQIICAIEYC-HRHKIVHRDL 134 Query: 192 KPSNILVNSRGEIKLCDFGVSGQLID-SMANSFVGTRSYMSPERLQGTHYSV-QSDIWSM 249 KP N+L++ +K+ DFG+S + D + + G+ +Y +PE + G Y+ + D+WS Sbjct: 135 KPENLLLDDNLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVINGKLYAGPEVDVWSC 194 Query: 250 GLSLVEMAVGRYPI 263 G+ L M VGR P Sbjct: 195 GIVLYVMLVGRLPF 208 >4HVI-A nrPDB Length = 314 Score = 87.4 bits (215), Expect = 9e-18, Method: Compositional matrix adjust. Identities = 67/227 (29%), Positives = 107/227 (47%), Gaps = 20/227 (8%) Query: 63 LKDDDFEKISELGAGNGGVVFKVSHKPSG-----LVMARKLIHLEIKPAIRNQIIRELQV 117 ++ + IS+LG GN G V + P G LV ++L H P + RE+Q+ Sbjct: 7 FEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQH--SGPDQQRDFQREIQI 64 Query: 118 LHECNSPYIVGFYGAFYSDGE--ISICMEHMDGGSLDQVLKK-AGRIPEQILGKVSIAVI 174 L +S +IV + G Y G + + ME++ G L L++ R+ L S + Sbjct: 65 LKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQIC 124 Query: 175 KGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRS------ 228 KG+ YL + + +HRD+ NILV S +K+ DFG++ L + + R Sbjct: 125 KGMEYLGSR-RCVHRDLAARNILVESEAHVKIADFGLAKLL--PLDKDYYVVREPGQSPI 181 Query: 229 -YMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELM 274 + +PE L +S QSD+WS G+ L E+ P A+ L +M Sbjct: 182 FWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMM 228 >5EZV-A nrPDB Length = 560 Score = 87.4 bits (215), Expect = 9e-18, Method: Compositional matrix adjust. Identities = 57/197 (28%), Positives = 101/197 (51%), Gaps = 11/197 (5%) Query: 74 LGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRN-----QIIRELQVLHECNSPYIVG 128 LG G G V H+ +G +A K+++ + IR+ +I RE+Q L P+I+ Sbjct: 36 LGVGTFGKVKIGEHQLTGHKVAVKILN---RQKIRSLDVVGKIKREIQNLKLFRHPHIIK 92 Query: 129 FYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMH 188 Y + + + ME++ GG L + K GR+ E ++ ++ + Y +H ++H Sbjct: 93 LYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYC-HRHMVVH 151 Query: 189 RDVKPSNILVNSRGEIKLCDFGVSGQLID-SMANSFVGTRSYMSPERLQGTHYSV-QSDI 246 RD+KP N+L+++ K+ DFG+S + D + G+ +Y +PE + G Y+ + DI Sbjct: 152 RDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDI 211 Query: 247 WSMGLSLVEMAVGRYPI 263 WS G+ L + G P Sbjct: 212 WSCGVILYALLCGTLPF 228 >5O2C-A nrPDB Length = 380 Score = 87.4 bits (215), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 78/307 (25%), Positives = 135/307 (43%), Gaps = 49/307 (15%) Query: 73 ELGAGNGGVVFKVSHKPSGLVMAR-KLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYG 131 ELG G V+K + + +A +L ++ A + + E ++L P IV FY Sbjct: 32 ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYD 91 Query: 132 AFYS--DGE--ISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHK-I 186 ++ S G+ I + E M G+L LK+ + ++L ++KGL +L + I Sbjct: 92 SWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPPI 151 Query: 187 MHRDVKPSNILVNS-RGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSD 245 +HRD+K NI + G +K+ D G++ + S A S +GT +M+PE + HY D Sbjct: 152 IHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSVIGTPEFMAPEMYE-EHYDESVD 210 Query: 246 IWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSR 305 +++ G+ ++EMA YP CQ +AA+ R T G +S+ + Sbjct: 211 VYAFGMCMLEMATSEYPYSE-----------CQ---NAAQI-YRKVTSGIKPASFNKVTD 255 Query: 306 PPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSD 365 P E ++ + C+ +N +ER ++ L+ HAF Sbjct: 256 P--------------------------EVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDT 289 Query: 366 AEEVDFA 372 V+ A Sbjct: 290 GLRVELA 296 >6QAU-A nrPDB Length = 280 Score = 87.0 bits (214), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 68/240 (28%), Positives = 115/240 (47%), Gaps = 20/240 (8%) Query: 65 DDDFEKISELGAGNGGVVFKVSHK-PSGLVMARKLIHLEIKPAIRNQII--RELQVLHEC 121 D ++ K +G G VVF+ H+ + +A K I+ K ++QI+ +E+++L E Sbjct: 10 DFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINK--KNLSKSQILLGKEIKILKEL 67 Query: 122 NSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLR 181 IV Y + + ME+ +GG L L+ G + E + +V + I + Sbjct: 68 QHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTI-RVFLHQIAAAMRIL 126 Query: 182 EKHKIMHRDVKPSNILV---NSRG------EIKLCDFGVSGQL-IDSMANSFVGTRSYMS 231 I+HRD+KP NIL+ N R IK+ DFG + L + MA G+ YM+ Sbjct: 127 HSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAADLCGSPMYMA 186 Query: 232 PERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPR 291 PE + HY ++D+WS+G + + VG+ P ++L + + E + + P PR Sbjct: 187 PEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFY----EKNRSLMPSIPR 242 >3SXS-A nrPDB Length = 268 Score = 87.0 bits (214), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 62/207 (29%), Positives = 110/207 (53%), Gaps = 11/207 (5%) Query: 62 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHEC 121 ELK ++ + ELG+G GVV K+ +A K+I + ++ +E Q + + Sbjct: 4 ELKREEITLLKELGSGQFGVV-KLGKWKGQYDVAVKMI--KEGSMSEDEFFQEAQTMMKL 60 Query: 122 NSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR--IPEQILGKVSIAVIKGLTY 179 + P +V FYG + I I E++ G L L+ G+ P Q+L ++ V +G+ + Sbjct: 61 SHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLL-EMCYDVCEGMAF 119 Query: 180 LREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTR---SYMSPERLQ 236 L E H+ +HRD+ N LV+ +K+ DFG++ ++D S VGT+ + +PE Sbjct: 120 L-ESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFH 178 Query: 237 GTHYSVQSDIWSMGLSLVEM-AVGRYP 262 YS +SD+W+ G+ + E+ ++G+ P Sbjct: 179 YFKYSSKSDVWAFGILMWEVFSLGKMP 205 >5JN2-A nrPDB Length = 525 Score = 87.0 bits (214), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 63/193 (32%), Positives = 103/193 (53%), Gaps = 10/193 (5%) Query: 74 LGAGNGGVVFKVSHKPSGLVMARKLI-HLEIKPAI-RNQIIRELQVLHECNSPYIVGFYG 131 LG G+ G V K +G A K+I ++K + ++RE+Q+L + + P I+ Y Sbjct: 75 LGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDHPNIMKLYE 134 Query: 132 AFYSDGEISICMEHMDGGSL-DQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRD 190 F G + E GG L D+++ + R E ++ V+ G+TY+ K+KI+HRD Sbjct: 135 FFEDKGYFYLVGEVYTGGELFDEIISRK-RFSEVDAARIIRQVLSGITYMH-KNKIVHRD 192 Query: 191 VKPSNILVNSRGE---IKLCDFGVSGQLIDSMA-NSFVGTRSYMSPERLQGTHYSVQSDI 246 +KP N+L+ S+ + I++ DFG+S S +GT Y++PE L GT Y + D+ Sbjct: 193 LKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVLHGT-YDEKCDV 251 Query: 247 WSMGLSLVEMAVG 259 WS G+ L + G Sbjct: 252 WSTGVILYILLSG 264 >3E3P-A nrPDB Length = 360 Score = 87.0 bits (214), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 75/236 (31%), Positives = 117/236 (49%), Gaps = 41/236 (17%) Query: 43 DEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMA-RKLIHL 101 DE+ RK ++ F ++ G G G V K +G+ +A +K+I Sbjct: 15 DERSRKEMDRFQVERMA---------------GQGTFGTVQLGKEKSTGMSVAIKKVIQ- 58 Query: 102 EIKPAIRN---QIIRELQVLHECNSPYIVGFYGAFYSDGE-------ISICMEHMDGGSL 151 P RN QI+++L VLH P IV FY+ GE +++ ME++ +L Sbjct: 59 --DPRFRNRELQIMQDLAVLHH---PNIVQLQSYFYTLGERDRRDIYLNVVMEYV-PDTL 112 Query: 152 DQVLKKAGR---IPEQILGKVSI-AVIKGLTYLR-EKHKIMHRDVKPSNILVN-SRGEIK 205 + + R P IL KV + +I+ + L + HRD+KP N+LVN + G +K Sbjct: 113 HRCCRNYYRRQVAPPPILIKVFLFQLIRSIGCLHLPSVNVCHRDIKPHNVLVNEADGTLK 172 Query: 206 LCDFGVSGQLIDSMAN-SFVGTRSYMSPERLQGT-HYSVQSDIWSMGLSLVEMAVG 259 LCDFG + +L S N +++ +R Y +PE + G HY+ DIWS+G EM +G Sbjct: 173 LCDFGSAKKLSPSEPNVAYICSRYYRAPELIFGNQHYTTAVDIWSVGCIFAEMMLG 228 >2PMN-X nrPDB Length = 348 Score = 86.7 bits (213), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 69/266 (25%), Positives = 115/266 (43%), Gaps = 34/266 (12%) Query: 114 ELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQ------VLKK--AGRIPEQI 165 ELQ++ + + Y + G + E+ I E+M+ S+ + VL K IP Q+ Sbjct: 93 ELQIITDIKNEYCLTCEGIITNYDEVYIIYEYMENDSILKFDEYFFVLDKNYTCFIPIQV 152 Query: 166 LGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVG 225 + + +V+ +Y+ + I HRDVKPSNIL++ G +KL DFG S ++D G Sbjct: 153 IKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMDKNGRVKLSDFGESEYMVDKKIKGSRG 212 Query: 226 TRSYMSPERL--QGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDA 283 T +M PE + ++ + DIWS+G+ L M Y + P K + + Sbjct: 213 TYEFMPPEFFSNESSYNGAKVDIWSLGICLYVMF---YNVVPFSLKISLVELFNNIRTKN 269 Query: 284 AETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLI 343 E P PL++ + S E DF+ L Sbjct: 270 IEYPLDRNHFLYPLTN---------------------KKSTCSNNFLSNEDIDFLKLFLR 308 Query: 344 KNPAERADLKQLMVHAFIKRSDAEEV 369 KNPAER + + H ++ ++ E++ Sbjct: 309 KNPAERITSEDALKHEWLADTNIEDL 334 >3MA6-A nrPDB Length = 298 Score = 86.7 bits (213), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 67/209 (32%), Positives = 111/209 (53%), Gaps = 14/209 (6%) Query: 74 LGAGNGGVVFKVSHKPSGLVMARKLI-HLEIKPAI-RNQIIRELQVLHECNSPYIVGFYG 131 LG G+ G V K +G A K+I ++K + ++RE+Q+L + + P I+ Y Sbjct: 40 LGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDHPNIMKLYE 99 Query: 132 AFYSDGEISICMEHMDGGSL-DQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRD 190 F G + E GG L D+++ + R E ++ V+ G+TY+ K+KI+HRD Sbjct: 100 FFEDKGYFYLVGEVYTGGELFDEIISRK-RFSEVDAARIIRQVLSGITYM-HKNKIVHRD 157 Query: 191 VKPSNILVNSRGE---IKLCDFGVSGQLIDSMA-NSFVGTRSYMSPERLQGTHYSVQSDI 246 +KP N+L+ S+ + I++ DFG+S S +GT Y++PE L GT Y + D+ Sbjct: 158 LKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVLHGT-YDEKCDV 216 Query: 247 WSMGLSLVEMAVGRYPIPPPD-AKELELM 274 WS G+ L + G PP + A E +++ Sbjct: 217 WSTGVILYILLSG---CPPFNGANEYDIL 242 >5UUU-A nrPDB Length = 547 Score = 86.7 bits (213), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 58/213 (27%), Positives = 107/213 (50%), Gaps = 11/213 (5%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLI---HLEIKP----AIRNQIIRELQVL 118 +DF +G G G V+ +G + A K + +++K A+ +I+ L Sbjct: 198 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 257 Query: 119 HECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLT 178 +C P+IV AF++ ++S ++ M+GG L L + G E + + +I GL Sbjct: 258 GDC--PFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLE 315 Query: 179 YLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQ-G 237 ++ + +++RD+KP+NIL++ G +++ D G++ ++ VGT YM+PE LQ G Sbjct: 316 HMHNRF-VVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKG 374 Query: 238 THYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKE 270 Y +D +S+G L ++ G P K+ Sbjct: 375 VAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKD 407 >3PVW-A nrPDB Length = 695 Score = 86.7 bits (213), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 58/213 (27%), Positives = 107/213 (50%), Gaps = 11/213 (5%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLI---HLEIKP----AIRNQIIRELQVL 118 +DF +G G G V+ +G + A K + +++K A+ +I+ L Sbjct: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 Query: 119 HECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLT 178 +C P+IV AF++ ++S ++ M+GG L L + G E + + +I GL Sbjct: 249 GDC--PFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLE 306 Query: 179 YLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQ-G 237 ++ + +++RD+KP+NIL++ G +++ D G++ ++ VGT YM+PE LQ G Sbjct: 307 HMHNRF-VVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKG 365 Query: 238 THYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKE 270 Y +D +S+G L ++ G P K+ Sbjct: 366 VAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKD 398 >2A1A-B nrPDB Length = 284 Score = 86.7 bits (213), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 65/210 (30%), Positives = 106/210 (50%), Gaps = 27/210 (12%) Query: 67 DFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYI 126 DF++I +G+G G VFK H+ G K + + A R ++ L L N + Sbjct: 12 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAERE--VKALAKLDHVNIVHY 69 Query: 127 VGFYGAFYSDGEIS-------------ICMEHMDGGSLDQVL-KKAGRIPEQILG-KVSI 171 G + F D E S I ME D G+L+Q + K+ G +++L ++ Sbjct: 70 NGCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFE 129 Query: 172 AVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRS--- 228 + KG+ Y+ K K+++RD+KPSNI + ++K+ DFG L+ S+ N TRS Sbjct: 130 QITKGVDYIHSK-KLINRDLKPSNIFLVDTKQVKIGDFG----LVTSLKNDGKRTRSKGT 184 Query: 229 --YMSPERLQGTHYSVQSDIWSMGLSLVEM 256 YMSPE++ Y + D++++GL L E+ Sbjct: 185 LRYMSPEQISSQDYGKEVDLYALGLILAEL 214 >5VO2-A nrPDB Length = 300 Score = 86.3 bits (212), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 62/208 (29%), Positives = 99/208 (47%), Gaps = 15/208 (7%) Query: 68 FEKISEL---GAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSP 124 FE+I +L G+G G VF + + + +R+ +++ L + P Sbjct: 11 FEEILDLQWVGSGAQGAVFLGRFHGEEVAVKK----------VRDLKETDIKHLRKLKHP 60 Query: 125 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKH 184 I+ F G I ME G L +VL+ + +L S+ + G+ YL H Sbjct: 61 NIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLH-LH 119 Query: 185 KIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID-SMANSFVGTRSYMSPERLQGTHYSVQ 243 KI+HRD+K N+L+ +K+ DFG S +L D S SF GT ++M+PE ++ S + Sbjct: 120 KIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEK 179 Query: 244 SDIWSMGLSLVEMAVGRYPIPPPDAKEL 271 DIWS G+ L E+ G P D+ + Sbjct: 180 VDIWSFGVVLWELLTGEIPYKDVDSSAI 207 >3UTO-A nrPDB Length = 573 Score = 85.5 bits (210), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 57/193 (29%), Positives = 97/193 (50%), Gaps = 12/193 (6%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLI---HLEIKPAIRNQIIRELQVLHECN 122 D ++ ELG G GVV +V+ + +G A K + H K +R +E+Q + Sbjct: 157 DHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKETVR----KEIQTMSVLR 212 Query: 123 SPYIVGFYGAFYSDGEISICMEHMDGGSL-DQVLKKAGRIPEQILGKVSIAVIKGLTYLR 181 P +V + AF D E+ + E M GG L ++V + ++ E + V KGL ++ Sbjct: 213 HPTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMRQVCKGLCHMH 272 Query: 182 EKHKIMHRDVKPSNILVNSR--GEIKLCDFGVSGQLIDSMA-NSFVGTRSYMSPERLQGT 238 E + + H D+KP NI+ ++ E+KL DFG++ L + GT + +PE +G Sbjct: 273 ENNYV-HLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTTGTAEFAAPEVAEGK 331 Query: 239 HYSVQSDIWSMGL 251 +D+WS+G+ Sbjct: 332 PVGYYTDMWSVGV 344 >1KOA-A nrPDB Length = 491 Score = 85.5 bits (210), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 57/193 (29%), Positives = 97/193 (50%), Gaps = 12/193 (6%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLI---HLEIKPAIRNQIIRELQVLHECN 122 D ++ ELG G GVV +V+ + +G A K + H K +R +E+Q + Sbjct: 51 DHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKETVR----KEIQTMSVLR 106 Query: 123 SPYIVGFYGAFYSDGEISICMEHMDGGSL-DQVLKKAGRIPEQILGKVSIAVIKGLTYLR 181 P +V + AF D E+ + E M GG L ++V + ++ E + V KGL ++ Sbjct: 107 HPTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMRQVCKGLCHMH 166 Query: 182 EKHKIMHRDVKPSNILVNSR--GEIKLCDFGVSGQLIDSMA-NSFVGTRSYMSPERLQGT 238 E + + H D+KP NI+ ++ E+KL DFG++ L + GT + +PE +G Sbjct: 167 ENNYV-HLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTTGTAEFAAPEVAEGK 225 Query: 239 HYSVQSDIWSMGL 251 +D+WS+G+ Sbjct: 226 PVGYYTDMWSVGV 238 >4D28-A nrPDB Length = 446 Score = 85.5 bits (210), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 56/178 (31%), Positives = 89/178 (50%), Gaps = 7/178 (3%) Query: 93 VMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLD 152 +MA+ I +K + +QI RE+ ++ P IV Y S +I I +E + GG L Sbjct: 41 IMAKSTI---LKNRMVDQIKREISIMKIVRHPNIVRLYEVLASKSKIYIVLEFVTGGELF 97 Query: 153 QVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVS 212 + GR+ E K ++ + + K + HRD+KP N+L+++ G +K+ DFG+S Sbjct: 98 DRIVHKGRLKEDESRKYFQQLVDAVAHCHSK-GVYHRDLKPENLLLDTNGNLKVSDFGLS 156 Query: 213 G--QLIDSMANSFVGTRSYMSPERLQGTHYS-VQSDIWSMGLSLVEMAVGRYPIPPPD 267 Q + N GT +Y++PE L G Y +DIWS G+ L + G P D Sbjct: 157 ALPQEGVELLNDTCGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETD 214 >5O2B-A nrPDB Length = 285 Score = 85.5 bits (210), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 76/296 (25%), Positives = 132/296 (44%), Gaps = 49/296 (16%) Query: 73 ELGAGNGGVVFKVSHKPSGLVMAR-KLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYG 131 ELG G V+K + + +A +L ++ A + + E ++L P IV FY Sbjct: 23 ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYD 82 Query: 132 AFYS--DGE--ISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHK-I 186 ++ S G+ I + E M G+L LK+ + ++L ++KGL +L + I Sbjct: 83 SWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPPI 142 Query: 187 MHRDVKPSNILVNS-RGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSD 245 +HRD+K NI + G +K+ D G++ + S A S +GT +M+PE + HY D Sbjct: 143 IHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSVIGTPEFMAPEMYE-EHYDESVD 201 Query: 246 IWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSR 305 +++ G+ ++EMA YP CQ +AA+ R T G +S+ + Sbjct: 202 VYAFGMCMLEMATSEYPYSE-----------CQ---NAAQI-YRKVTSGIKPASFNKVTD 246 Query: 306 PPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFI 361 P E ++ + C+ +N +ER ++ L+ HAF Sbjct: 247 P--------------------------EVKEIIEGCIRQNKSERLSIRDLLNHAFF 276 >3DTC-A nrPDB Length = 271 Score = 85.1 bits (209), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 61/216 (28%), Positives = 103/216 (47%), Gaps = 17/216 (7%) Query: 102 EIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRI 161 +I I N + +E ++ P I+ G + + + ME GG L++VL RI Sbjct: 45 DISQTIEN-VRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLS-GKRI 102 Query: 162 PEQILGKVSIAVIKGLTYLREKH--KIMHRDVKPSNILVNSRGE--------IKLCDFGV 211 P IL ++ + +G+ YL ++ I+HRD+K SNIL+ + E +K+ DFG+ Sbjct: 103 PPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGL 162 Query: 212 SGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKEL 271 + + + S G ++M+PE ++ + +S SD+WS G+ L E+ G P D L Sbjct: 163 AREWHRTTKMSAAGAYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDG--L 220 Query: 272 ELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPP 307 + +G + A P P T P + D P Sbjct: 221 AVAYGVAMNKLAL---PIPSTCPEPFAKLMEDCWNP 253 >3DB8-A nrPDB Length = 317 Score = 85.1 bits (209), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 54/201 (26%), Positives = 104/201 (51%), Gaps = 5/201 (2%) Query: 74 LGAGNGGVVFKVSHKPSGLVMARKLI--HLEIKPAIRNQIIRELQVLHECNSPYIVGFYG 131 LG G ++++ + V A K++ + +KP + ++ E+ + ++P++VGF+G Sbjct: 50 LGKGGFAKCYEITDMDTKEVFAGKVVPKSMLLKPHQKEKMSTEIAIHKSLDNPHVVGFHG 109 Query: 132 AFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDV 191 F D + + +E SL ++ K+ + E I+G+ YL ++++HRD+ Sbjct: 110 FFEDDDFVYVVLEICRRRSLLELHKRRKAVTEPEARYFMRQTIQGVQYL-HNNRVIHRDL 168 Query: 192 KPSNILVNSRGEIKLCDFGVSGQL-ID-SMANSFVGTRSYMSPERLQGTHYSVQSDIWSM 249 K N+ +N ++K+ DFG++ ++ D GT +Y++PE L +S + DIWS+ Sbjct: 169 KLGNLFLNDDMDVKIGDFGLATKIEFDGERKKDLCGTPNYIAPEVLCKKGHSFEVDIWSL 228 Query: 250 GLSLVEMAVGRYPIPPPDAKE 270 G L + VG+ P KE Sbjct: 229 GCILYTLLVGKPPFETSCLKE 249 >4APC-A nrPDB Length = 350 Score = 85.1 bits (209), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 58/214 (27%), Positives = 107/214 (50%), Gaps = 8/214 (3%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHL-EIKPAIRNQIIRELQVLHECNSP 124 + + ++ ++G G+ G V G K I++ + R + RE+ VL P Sbjct: 24 EKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKHP 83 Query: 125 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRI---PEQILGKVSIAVIKGLTYLR 181 IV + +F +G + I M++ +GG L + + + +QIL + + L ++ Sbjct: 84 NIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWF-VQICLALKHVH 142 Query: 182 EKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS--MANSFVGTRSYMSPERLQGTH 239 ++ KI+HRD+K NI + G ++L DFG++ L + +A + +GT Y+SPE + Sbjct: 143 DR-KILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARACIGTPYYLSPEICENKP 201 Query: 240 YSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELEL 273 Y+ +SDIW++G L E+ ++ K L L Sbjct: 202 YNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVL 235 >5LPZ-A nrPDB Length = 332 Score = 84.7 bits (208), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 63/211 (29%), Positives = 106/211 (50%), Gaps = 14/211 (6%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIV 127 F S +G+G G V+K K V +KLIH+ + + + E++ + + +V Sbjct: 19 FHNDSLIGSGGFGDVYKAILKDGSAVAIKKLIHVSGQG--DREFMAEMETIGKIKHRNLV 76 Query: 128 GFYGAFYSDGEISICMEHMDGGSLDQVL---KKAG-RIPEQILGKVSIAVIKGLTYLREK 183 G E + E M GSL+ VL KKAG ++ K++I +GL +L Sbjct: 77 PLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHHN 136 Query: 184 HK--IMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSM-----ANSFVGTRSYMSPERLQ 236 I+HRD+K SN+L++ E ++ DFG++ +L+ +M ++ GT Y+ PE Q Sbjct: 137 CSPHIIHRDMKSSNVLLDENLEARVSDFGMA-RLMSAMDTHLSVSTLAGTPGYVPPEYYQ 195 Query: 237 GTHYSVQSDIWSMGLSLVEMAVGRYPIPPPD 267 S + D++S G+ L+E+ G+ P PD Sbjct: 196 SFRCSTKGDVYSYGVVLLELLTGKRPTDSPD 226 >5LPV-A nrPDB Length = 296 Score = 84.7 bits (208), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 63/211 (29%), Positives = 106/211 (50%), Gaps = 14/211 (6%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIV 127 F S +G+G G V+K K V +KLIH+ + + + E++ + + +V Sbjct: 19 FHNDSLIGSGGFGDVYKAILKDGSAVAIKKLIHVSGQG--DREFMAEMETIGKIKHRNLV 76 Query: 128 GFYGAFYSDGEISICMEHMDGGSLDQVL---KKAG-RIPEQILGKVSIAVIKGLTYLREK 183 G E + E M GSL+ VL KKAG ++ K++I +GL +L Sbjct: 77 PLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHHN 136 Query: 184 HK--IMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSM-----ANSFVGTRSYMSPERLQ 236 I+HRD+K SN+L++ E ++ DFG++ +L+ +M ++ GT Y+ PE Q Sbjct: 137 CSPHIIHRDMKSSNVLLDENLEARVSDFGMA-RLMSAMDTHLSVSTLAGTPGYVPPEYYQ 195 Query: 237 GTHYSVQSDIWSMGLSLVEMAVGRYPIPPPD 267 S + D++S G+ L+E+ G+ P PD Sbjct: 196 SFRCSTKGDVYSYGVVLLELLTGKRPTDSPD 226 >2I0E-A nrPDB Length = 353 Score = 84.7 bits (208), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 58/216 (26%), Positives = 104/216 (48%), Gaps = 10/216 (4%) Query: 63 LKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEI---KPAIRNQIIRELQVLH 119 +K DF + LG G+ G V K + + A K++ ++ + ++ + + Sbjct: 17 MKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLAL 76 Query: 120 ECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRI--PEQILGKVSIAVIKGL 177 P++ + F + + ME+++GG L +++ GR P + IA+ GL Sbjct: 77 PGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAI--GL 134 Query: 178 TYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLI--DSMANSFVGTRSYMSPERL 235 +L+ K I++RD+K N++++S G IK+ DFG+ + I +F GT Y++PE + Sbjct: 135 FFLQSK-GIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEII 193 Query: 236 QGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKEL 271 Y D W+ G+ L EM G+ P D EL Sbjct: 194 AYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDEL 229 >3DXN-A nrPDB Length = 287 Score = 84.7 bits (208), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 64/206 (31%), Positives = 103/206 (50%), Gaps = 15/206 (7%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQ--IIRELQVLHECNS 123 D ++++ +LG+G G V K +G A K+I N ++ E+ VL + + Sbjct: 21 DRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDH 80 Query: 124 PYIVGFYGAFYSDGEISICMEHMDGGSL-DQVL--KKAGRIPEQILGKVSIAVIKGLTYL 180 P I+ Y F + ME GG L D+++ +K + ++ K V+ G TYL Sbjct: 81 PNIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMK---QVLSGTTYL 137 Query: 181 REKHKIMHRDVKPSNILVNSRGE---IKLCDFGVSGQL-IDSMANSFVGTRSYMSPERLQ 236 KH I+HRD+KP N+L+ S+ IK+ DFG+S + +GT Y++PE L+ Sbjct: 138 H-KHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAPEVLR 196 Query: 237 GTHYSVQSDIWSMGLSLVEMAVGRYP 262 Y + D+WS G+ L + G YP Sbjct: 197 -KKYDEKCDVWSCGVILYILLCG-YP 220 >3PFQ-A nrPDB Length = 674 Score = 84.7 bits (208), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 58/216 (26%), Positives = 104/216 (48%), Gaps = 10/216 (4%) Query: 63 LKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEI---KPAIRNQIIRELQVLH 119 +K DF + LG G+ G V K + + A K++ ++ + ++ + + Sbjct: 338 MKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLAL 397 Query: 120 ECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRI--PEQILGKVSIAVIKGL 177 P++ + F + + ME+++GG L +++ GR P + IA+ GL Sbjct: 398 PGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAI--GL 455 Query: 178 TYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLI--DSMANSFVGTRSYMSPERL 235 +L+ K I++RD+K N++++S G IK+ DFG+ + I +F GT Y++PE + Sbjct: 456 FFLQSK-GIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEII 514 Query: 236 QGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKEL 271 Y D W+ G+ L EM G+ P D EL Sbjct: 515 AYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDEL 550 >4E93-A nrPDB Length = 377 Score = 84.7 bits (208), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 61/208 (29%), Positives = 99/208 (47%), Gaps = 7/208 (3%) Query: 63 LKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECN 122 L +D ++G GN G VF + ++A K + P ++ + ++E ++L + + Sbjct: 111 LNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYS 170 Query: 123 SPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAG-RIPEQILGKVSIAVIKGLTYLR 181 P IV G I I ME + GG L+ G R+ + L ++ G+ YL Sbjct: 171 HPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLE 230 Query: 182 EKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRS----YMSPERLQG 237 K I HRD+ N LV + +K+ DFG+S + D + + G R + +PE L Sbjct: 231 SKCCI-HRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNY 289 Query: 238 THYSVQSDIWSMGLSLVE-MAVGRYPIP 264 YS +SD+WS G+ L E ++G P P Sbjct: 290 GRYSSESDVWSFGILLWETFSLGASPYP 317 >3KK8-A nrPDB Length = 284 Score = 84.7 bits (208), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 65/228 (28%), Positives = 115/228 (50%), Gaps = 12/228 (5%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRN--QIIRELQVLHECNS 123 D+++ ELG G VV + HK +GL A K+I+ + K + R+ ++ RE ++ + Sbjct: 6 DNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTK-KLSARDFQKLEREARICRKLQH 64 Query: 124 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREK 183 P IV + + + + + + GG L + + E +++ + Y Sbjct: 65 PNIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCHS- 123 Query: 184 HKIMHRDVKPSNILVNSRGE---IKLCDFGVSGQLIDSMA-NSFVGTRSYMSPERLQGTH 239 + I+HR++KP N+L+ S+ + +KL DFG++ ++ DS A + F GT Y+SPE L+ Sbjct: 124 NGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVLKKDP 183 Query: 240 YSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETP 287 YS DIW+ G+ L + VG PP E + Q++ A + P Sbjct: 184 YSKPVDIWACGVILYILLVGY----PPFWDEDQHRLYAQIKAGAYDYP 227 >3HZT-A nrPDB Length = 467 Score = 84.7 bits (208), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 64/206 (31%), Positives = 103/206 (50%), Gaps = 15/206 (7%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQ--IIRELQVLHECNS 123 D ++++ +LG+G G V K +G A K+I N ++ E+ VL + + Sbjct: 4 DRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDH 63 Query: 124 PYIVGFYGAFYSDGEISICMEHMDGGSL-DQVL--KKAGRIPEQILGKVSIAVIKGLTYL 180 P I+ Y F + ME GG L D+++ +K + ++ K V+ G TYL Sbjct: 64 PNIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMK---QVLSGTTYL 120 Query: 181 REKHKIMHRDVKPSNILVNSRGE---IKLCDFGVSGQL-IDSMANSFVGTRSYMSPERLQ 236 KH I+HRD+KP N+L+ S+ IK+ DFG+S + +GT Y++PE L+ Sbjct: 121 H-KHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAPEVLR 179 Query: 237 GTHYSVQSDIWSMGLSLVEMAVGRYP 262 Y + D+WS G+ L + G YP Sbjct: 180 -KKYDEKCDVWSCGVILYILLCG-YP 203 >3PP0-A nrPDB Length = 338 Score = 84.7 bits (208), Expect = 7e-17, Method: Compositional matrix adjust. Identities = 64/219 (29%), Positives = 108/219 (49%), Gaps = 12/219 (5%) Query: 63 LKDDDFEKISELGAGNGGVVFKVSHKPSG----LVMARKLIHLEIKPAIRNQIIRELQVL 118 LK+ + K+ LG+G G V+K P G + +A K++ P +I+ E V+ Sbjct: 14 LKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVM 73 Query: 119 HECNSPYIVGFYGAFYSDGEISICMEHMDGGSL-DQVLKKAGRIPEQILGKVSIAVIKGL 177 SPY+ G + + + + M G L D V + GR+ Q L + + KG+ Sbjct: 74 AGVGSPYVSRLLGICLT-STVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGM 132 Query: 178 TYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL-IDSMANSFVGTR---SYMSPE 233 +YL E +++HRD+ N+LV S +K+ DFG++ L ID G + +M+ E Sbjct: 133 SYL-EDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALE 191 Query: 234 RLQGTHYSVQSDIWSMGLSLVE-MAVGRYPIPPPDAKEL 271 + ++ QSD+WS G+++ E M G P A+E+ Sbjct: 192 SILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREI 230 >2YZA-A nrPDB Length = 276 Score = 84.7 bits (208), Expect = 7e-17, Method: Compositional matrix adjust. Identities = 57/197 (28%), Positives = 100/197 (50%), Gaps = 11/197 (5%) Query: 74 LGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRN-----QIIRELQVLHECNSPYIVG 128 LG G G V H+ +G +A K+++ + IR+ +I RE+Q L P+I+ Sbjct: 19 LGVGTFGKVKIGEHQLTGHKVAVKILN---RQKIRSLDVVGKIKREIQNLKLFRHPHIIK 75 Query: 129 FYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMH 188 Y + + + ME++ GG L + K GR+ E ++ ++ + Y +H ++H Sbjct: 76 LYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYC-HRHMVVH 134 Query: 189 RDVKPSNILVNSRGEIKLCDFGVSGQLIDS-MANSFVGTRSYMSPERLQGTHYSV-QSDI 246 RD+KP N+L+++ K+ DFG+S + D G+ +Y +PE + G Y+ + DI Sbjct: 135 RDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRDSCGSPNYAAPEVISGRLYAGPEVDI 194 Query: 247 WSMGLSLVEMAVGRYPI 263 WS G+ L + G P Sbjct: 195 WSCGVILYALLCGTLPF 211 >2BDW-A nrPDB Length = 362 Score = 84.3 bits (207), Expect = 7e-17, Method: Compositional matrix adjust. Identities = 65/228 (28%), Positives = 115/228 (50%), Gaps = 12/228 (5%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRN--QIIRELQVLHECNS 123 D+++ ELG G VV + HK +GL A K+I+ + K + R+ ++ RE ++ + Sbjct: 29 DNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTK-KLSARDFQKLEREARICRKLQH 87 Query: 124 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREK 183 P IV + + + + + + GG L + + E +++ + Y Sbjct: 88 PNIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCHS- 146 Query: 184 HKIMHRDVKPSNILVNSRGE---IKLCDFGVSGQLIDSMA-NSFVGTRSYMSPERLQGTH 239 + I+HR++KP N+L+ S+ + +KL DFG++ ++ DS A + F GT Y+SPE L+ Sbjct: 147 NGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVLKKDP 206 Query: 240 YSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETP 287 YS DIW+ G+ L + VG PP E + Q++ A + P Sbjct: 207 YSKPVDIWACGVILYILLVGY----PPFWDEDQHRLYAQIKAGAYDYP 250 >4UYA-A nrPDB Length = 340 Score = 84.3 bits (207), Expect = 9e-17, Method: Compositional matrix adjust. Identities = 66/237 (27%), Positives = 114/237 (48%), Gaps = 19/237 (8%) Query: 74 LGAGNGGVVFKVSHKPSGL-VMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGA 132 +GAG G V++ + + + V A + + A + RE ++ P I+ G Sbjct: 34 IGAGGFGQVYRATWQGQEVAVKAARQDPEQDAAAAAESVRREARLFAMLRHPNIIELRGV 93 Query: 133 FYSDGEISICMEHMDGGSLDQVLKKAGR-IPEQILGKVSIAVIKGLTYLREKH--KIMHR 189 + + +E GG+L++ L AGR IP +L ++ + +G+ YL E+ I+HR Sbjct: 94 CLQQPHLCLVLEFARGGALNRAL--AGRRIPPHVLVNWAVQIARGMLYLHEEAFVPILHR 151 Query: 190 DVKPSNILVNSRGE--------IKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYS 241 D+K SNIL+ + E +K+ DFG++ + + + G ++M+PE ++ + +S Sbjct: 152 DLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTKMATAGAYAWMAPEVIKSSLFS 211 Query: 242 VQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLS 298 SDIWS G+ L E+ G P D L + +G V T P P T P + Sbjct: 212 KGSDIWSYGVLLWELLTGEVPYRGIDG--LAVAYGVAVN---KLTLPIPSTCPEPFA 263 >5XZW-A nrPDB Length = 471 Score = 84.0 bits (206), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 68/228 (29%), Positives = 102/228 (44%), Gaps = 20/228 (8%) Query: 67 DFEKISEL-GAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPY 125 DF I E+ G G V K + +G A K+I + + REL+VL + N P Sbjct: 196 DFSIIDEVVGQGAFATVKKAIERTTGKTFAVKIISKRKVIGNMDGVTRELEVLQKLNHPR 255 Query: 126 IVGFYGAFYSDGE-ISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKH 184 IV G FY D E + ME + GG L + G + E ++S ++ + Y+ Sbjct: 256 IVRLKG-FYEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHS-M 313 Query: 185 KIMHRDVKPSNILVNSRGE--IKLCDFGVSG-QLIDSMANSFVGTRSYMSPERLQG---- 237 I HRD+KP NIL+ +K+ DFG++ Q S +F GT +Y++PE ++G Sbjct: 314 GISHRDLKPDNILIEQDDPVLVKITDFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDTS 373 Query: 238 ---------THYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFG 276 YS D+WSMG + + G P +L G Sbjct: 374 VSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIG 421 >3IS5-A nrPDB Length = 285 Score = 84.0 bits (206), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 75/281 (26%), Positives = 124/281 (44%), Gaps = 27/281 (9%) Query: 65 DDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSP 124 DD F +LG+G G V V + SGL K I+ + QI E++VL + P Sbjct: 21 DDLFIFKRKLGSGAFGDVHLVEERSSGLERVIKTINKDRSQVPMEQIEAEIEVLKSLDHP 80 Query: 125 YIVGFYGAFYSDGEISICMEHMDGGS-LDQVLKKAGR---IPEQILGKVSIAVIKGLTYL 180 I+ + F + I ME +GG L++++ R + E + ++ ++ L Y Sbjct: 81 NIIKIFEVFEDYHNMYIVMETCEGGELLERIVSAQARGKALSEGYVAELMKQMMNALAYF 140 Query: 181 REKHKIMHRDVKPSNILVNS---RGEIKLCDFGVSGQL-IDSMANSFVGTRSYMSPERLQ 236 +H ++H+D+KP NIL IK+ DFG++ D + + GT YM+PE + Sbjct: 141 HSQH-VVHKDLKPENILFQDTSPHSPIKIIDFGLAELFKSDEHSTNAAGTALYMAPEVFK 199 Query: 237 GTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRP 296 + + DIWS G+ + + G P +E V+ A P RP Sbjct: 200 -RDVTFKCDIWSAGVVMYFLLTGCLPFTGTSLEE--------VQQKATYKEPNYAVECRP 250 Query: 297 LSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDF 337 L+ P A+ +LL ++ + P + PS L + F Sbjct: 251 LT--------PQAV-DLLKQMLTKDPERRPSAAQVLHHEWF 282 >3UIU-A nrPDB Length = 306 Score = 83.6 bits (205), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 65/223 (29%), Positives = 106/223 (47%), Gaps = 40/223 (17%) Query: 67 DFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYI 126 DF++I +G+G G VFK H+ G + + + A R ++ L L N + Sbjct: 13 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIRRVKYNNEKAERE--VKALAKLDHVNIVHY 70 Query: 127 VGFYGAFYSDGEIS--------------------------ICMEHMDGGSLDQVL-KKAG 159 G + F D E S I ME D G+L+Q + K+ G Sbjct: 71 NGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRG 130 Query: 160 RIPEQILG-KVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS 218 +++L ++ + KG+ Y+ K K++HRD+KPSNI + ++K+ DFG L+ S Sbjct: 131 EKLDKVLALELFEQITKGVDYIHSK-KLIHRDLKPSNIFLVDTKQVKIGDFG----LVTS 185 Query: 219 MANSFVGTRS-----YMSPERLQGTHYSVQSDIWSMGLSLVEM 256 + N TRS YMSPE++ Y + D++++GL L E+ Sbjct: 186 LKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAEL 228 >2W96-B nrPDB Length = 306 Score = 83.6 bits (205), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 62/201 (30%), Positives = 97/201 (48%), Gaps = 14/201 (6%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIH-------LEIKPAIRNQIIRELQVLHE 120 +E ++E+G G G V+K SG +A K + L I ++R L+ Sbjct: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGLPISTVREVALLRRLEAFEH 65 Query: 121 CNSPYIVGFYGAFYSDGEISICM--EHMDGGSLDQVLKKAG--RIPEQILGKVSIAVIKG 176 N ++ +D EI + + EH+D L L KA +P + + + ++G Sbjct: 66 PNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQFLRG 124 Query: 177 LTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA-NSFVGTRSYMSPERL 235 L +L + I+HRD+KP NILV S G +KL DFG++ MA + V T Y +PE L Sbjct: 125 LDFL-HANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALDPVVVTLWYRAPEVL 183 Query: 236 QGTHYSVQSDIWSMGLSLVEM 256 + Y+ D+WS+G EM Sbjct: 184 LQSTYATPVDMWSVGCIFAEM 204 >3LIJ-A nrPDB Length = 494 Score = 83.6 bits (205), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 61/204 (29%), Positives = 106/204 (51%), Gaps = 16/204 (7%) Query: 68 FEKISELGAGNGGVVF----KVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNS 123 ++++ +LG+G G V KV+H + + RK + + ++++ E+ VL + Sbjct: 39 YQRVKKLGSGAYGEVLLCRDKVTHVERAIKIIRKT---SVSTSSNSKLLEEVAVLKLLDH 95 Query: 124 PYIVGFYGAFYSDGEISICMEHMDGGSL-DQVLKKAGRIPEQILGKVSIAVIKGLTYLRE 182 P I+ Y F + ME GG L D+++ + + E + V+ G+TYL Sbjct: 96 PNIMKLYDFFEDKRNYYLVMECYKGGELFDEIIHRM-KFNEVDAAVIIKQVLSGVTYLH- 153 Query: 183 KHKIMHRDVKPSNILVNSRGE---IKLCDFGVSGQLIDSMA-NSFVGTRSYMSPERLQGT 238 KH I+HRD+KP N+L+ S+ + IK+ DFG+S + +GT Y++PE L+ Sbjct: 154 KHNIVHRDLKPENLLLESKEKDALIKIVDFGLSAVFENQKKMKERLGTAYYIAPEVLR-K 212 Query: 239 HYSVQSDIWSMGLSLVEMAVGRYP 262 Y + D+WS+G+ L + G YP Sbjct: 213 KYDEKCDVWSIGVILFILLAG-YP 235 >6J5U-C nrPDB Length = 426 Score = 83.2 bits (204), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 70/221 (31%), Positives = 117/221 (52%), Gaps = 27/221 (12%) Query: 62 ELKD--DDFEKISELGAGNGGVVFK---------VSHKPSGLVMARKLIHLEIKP---AI 107 ELK+ +F + + LG G G VFK S SG+V+A K ++KP Sbjct: 78 ELKNATKNFRQDNLLGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVK----QLKPEGFQG 133 Query: 108 RNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICM-EHMDGGSLDQVLKKAGRIP--EQ 164 + + E+ L + + P +V G + ++GE + + E M GSL+ L + G P Sbjct: 134 HKEWLTEVNYLGQLSHPNLVLLVG-YCAEGENRLLVYEFMPKGSLENHLFRRGAQPLTWA 192 Query: 165 ILGKVSIAVIKGLTYLRE-KHKIMHRDVKPSNILVNSRGEIKLCDFGVS--GQLIDS--M 219 I KV++ KGLT+L E K ++++RD K +NIL+++ KL DFG++ G D+ + Sbjct: 193 IRMKVAVGAAKGLTFLHEAKSQVIYRDFKAANILLDADFNAKLSDFGLAKAGPTGDNTHV 252 Query: 220 ANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGR 260 + +GT Y +PE + + +SD++S G+ L+E+ GR Sbjct: 253 STKVIGTHGYAAPEYVATGRLTAKSDVYSFGVVLLELISGR 293 >2W4O-A nrPDB Length = 349 Score = 83.2 bits (204), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 63/216 (29%), Positives = 109/216 (50%), Gaps = 14/216 (6%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIR-ELQVLHECNSP 124 D FE SELG G +V++ K + A K++ K + +I+R E+ VL + P Sbjct: 53 DFFEVESELGRGATSIVYRCKQKGTQKPYALKVL----KKTVDKKIVRTEIGVLLRLSHP 108 Query: 125 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKH 184 I+ F + EIS+ +E + GG L + + G E+ +++ + YL E + Sbjct: 109 NIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHE-N 167 Query: 185 KIMHRDVKPSNILVNS---RGEIKLCDFGVSGQLIDS--MANSFVGTRSYMSPERLQGTH 239 I+HRD+KP N+L + +K+ DFG+S ++++ + + GT Y +PE L+G Sbjct: 168 GIVHRDLKPENLLYATPAPDAPLKIADFGLS-KIVEHQVLMKTVCGTPGYCAPEILRGCA 226 Query: 240 YSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMF 275 Y + D+WS+G+ + G P D + + MF Sbjct: 227 YGPEVDMWSVGIITYILLCGFEPF--YDERGDQFMF 260 >3QA8-A nrPDB Length = 676 Score = 82.4 bits (202), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 67/217 (30%), Positives = 101/217 (46%), Gaps = 26/217 (11%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIV 127 +E LG G G V + H+ +G +A K E+ P R + E+Q++ + N P +V Sbjct: 16 WEMKERLGTGGFGYVLRWIHQDTGEQVAIKQCRQELSPKNRERWCLEIQIMKKLNHPNVV 75 Query: 128 -------GFYGAFYSDGEISICMEHMDGGSLDQVLK--------KAGRIPEQILGKVSIA 172 G +D + + ME+ +GG L + L K G I +L +S A Sbjct: 76 SAREVPDGLQKLAPNDLPL-LAMEYCEGGDLRKYLNQFENCCGLKEGPI-RTLLSDISSA 133 Query: 173 VIKGLTYLREKHKIMHRDVKPSNILVN---SRGEIKLCDFGVSGQLID-SMANSFVGTRS 228 L YL E ++I+HRD+KP NI++ R K+ D G + +L + FVGT Sbjct: 134 ----LRYLHE-NRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQGELCTEFVGTLQ 188 Query: 229 YMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPP 265 Y++PE L+ Y+V D WS G E G P P Sbjct: 189 YLAPELLEQKKYTVTVDYWSFGTLAFECITGFRPFLP 225 >4M7I-A nrPDB Length = 299 Score = 82.4 bits (202), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 64/219 (29%), Positives = 101/219 (46%), Gaps = 30/219 (13%) Query: 67 DFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYI 126 DFE I LG G GVVF+ +K A K I L + R +++RE++ L + P I Sbjct: 6 DFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGI 65 Query: 127 VGFYGAFYSDGE------------ISICMEHMDGGSLDQVLKKAGRIPEQ---ILGKVSI 171 V ++ A+ + I M+ +L + I E+ + + + Sbjct: 66 VRYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFL 125 Query: 172 AVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFG-VSGQLIDSMANSF------- 223 + + + +L K +MHRD+KPSNI +K+ DFG V+ D + Sbjct: 126 QIAEAVEFLHSK-GLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAY 184 Query: 224 ------VGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEM 256 VGT+ YMSPE++ G YS + DI+S+GL L E+ Sbjct: 185 ARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFEL 223 >2X4F-A nrPDB Length = 373 Score = 82.4 bits (202), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 59/214 (27%), Positives = 114/214 (53%), Gaps = 15/214 (7%) Query: 74 LGAGNGGVVFKVSHKPSGLVMARKLIH---LEIKPAIRNQIIRELQVLHECNSPYIVGFY 130 LG G G V K +GL +A K+I ++ K ++N E+ V+++ + ++ Y Sbjct: 97 LGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKEEVKN----EISVMNQLDHANLIQLY 152 Query: 131 GAFYSDGEISICMEHMDGGSL-DQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHR 189 AF S +I + ME++DGG L D+++ ++ + E + +G+ ++ + + I+H Sbjct: 153 DAFESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQMY-ILHL 211 Query: 190 DVKPSNILVNSRG--EIKLCDFGVSGQLI--DSMANSFVGTRSYMSPERLQGTHYSVQSD 245 D+KP NIL +R +IK+ DFG++ + + + +F GT +++PE + S +D Sbjct: 212 DLKPENILCVNRDAKQIKIIDFGLARRYKPREKLKVNF-GTPEFLAPEVVNYDFVSFPTD 270 Query: 246 IWSMGLSLVEMAVGRYP-IPPPDAKELELMFGCQ 278 +WS+G+ + G P + DA+ L + C+ Sbjct: 271 MWSVGVIAYMLLSGLSPFLGDNDAETLNNILACR 304 >4RA4-A nrPDB Length = 355 Score = 82.0 bits (201), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 60/218 (27%), Positives = 111/218 (50%), Gaps = 14/218 (6%) Query: 63 LKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIR----ELQVL 118 +K DF + LG G+ G V K + + A K++ ++ I++ + E +VL Sbjct: 17 VKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDV--VIQDDDVECTMVEKRVL 74 Query: 119 HECNSP-YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRI--PEQILGKVSIAVIK 175 + P ++ + F + + ME+++GG L +++ G+ P+ + I++ Sbjct: 75 ALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISI-- 132 Query: 176 GLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQ-LIDSMAN-SFVGTRSYMSPE 233 GL +L K I++RD+K N++++S G IK+ DFG+ + ++D + +F GT Y++PE Sbjct: 133 GLFFLH-KRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPE 191 Query: 234 RLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKEL 271 + Y D W+ G+ L EM G+ P D EL Sbjct: 192 IIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDEL 229 >5HVK-A nrPDB Length = 315 Score = 82.0 bits (201), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 57/225 (25%), Positives = 102/225 (45%), Gaps = 21/225 (9%) Query: 74 LGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAF 133 LG G G KV+H+ +G VM K + + + ++E++V+ P ++ F G Sbjct: 22 LGKGCFGQAIKVTHRETGEVMVMKEL-IRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVL 80 Query: 134 YSDGEISICMEHMDGGSLDQVLKKA-GRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVK 192 Y D ++ E++ GG+L ++K + P + + G+ YL + I+HR++ Sbjct: 81 YKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMN-IIHRNLN 139 Query: 193 PSNILVNSRGEIKLCDFGVSGQLIDSMAN----------------SFVGTRSYMSPERLQ 236 N LV + + DFG++ ++D + VG +M+PE + Sbjct: 140 SHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPEMIN 199 Query: 237 GTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEG 281 G Y + D++S G+ L E+ +GR PD + FG V G Sbjct: 200 GRSYDEKVDVFSFGIVLCEI-IGRVN-ADPDYLPRTMDFGLNVRG 242 >1U59-A nrPDB Length = 287 Score = 82.0 bits (201), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 68/232 (29%), Positives = 114/232 (49%), Gaps = 28/232 (12%) Query: 73 ELGAGNGGVVFKVSHKPSGLVMARKLIHLEIK-------PAIRNQIIRELQVLHECNSPY 125 ELG GN G V + ++ M +K I + IK A +++RE Q++H+ ++PY Sbjct: 17 ELGCGNFGSVRQGVYR-----MRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPY 71 Query: 126 IVGFYGAFYSDGEISICMEHMDGGSLDQVL-KKAGRIPEQILGKVSIAVIKGLTYLREKH 184 IV G ++ + + ME GG L + L K IP + ++ V G+ YL EK+ Sbjct: 72 IVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKN 130 Query: 185 KIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRS-------YMSPERLQG 237 +HRD+ N+L+ +R K+ DFG+S L +S+ RS + +PE + Sbjct: 131 -FVHRDLAARNVLLVNRHYAKISDFGLSKAL--GADDSYYTARSAGKWPLKWYAPECINF 187 Query: 238 THYSVQSDIWSMGLSLVE-MAVGRYPIPPPDAKELELMFGCQVEGDAAETPP 288 +S +SD+WS G+++ E ++ G+ P E+ +G E PP Sbjct: 188 RKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIE---QGKRMECPP 236 >2VD5-A nrPDB Length = 412 Score = 82.0 bits (201), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 68/216 (31%), Positives = 105/216 (48%), Gaps = 18/216 (8%) Query: 63 LKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE--IKPAIRNQIIRELQVLHE 120 L+ DDFE + +G G V V K +G V A K+++ +K + E VL Sbjct: 58 LQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVN 117 Query: 121 CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAG-RIPEQILGKVSIAVIKGLTY 179 + +I + AF + + + ME+ GG L +L K G RIP + + + +A I + Sbjct: 118 GDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAE-MARFYLAEI--VMA 174 Query: 180 LREKHKI--MHRDVKPSNILVNSRGEIKLCDFGVSGQL-IDSMANSF--VGTRSYMSPER 234 + H++ +HRD+KP NIL++ G I+L DFG +L D S VGT Y+SPE Sbjct: 175 IDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEI 234 Query: 235 LQGTHYSV-------QSDIWSMGLSLVEMAVGRYPI 263 LQ + D W++G+ EM G+ P Sbjct: 235 LQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPF 270 >4KIK-B nrPDB Length = 677 Score = 81.6 bits (200), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 66/214 (30%), Positives = 101/214 (47%), Gaps = 20/214 (9%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIV 127 +E LG G G V + ++ +G +A K E+ P R + E+Q++ P +V Sbjct: 21 WEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQIMRRLTHPNVV 80 Query: 128 -------GFYGAFYSDGEISICMEHMDGGSLDQVLKK----AGRIPEQILGKVSIAVIKG 176 G +D + + ME+ GG L + L + G IL +S + Sbjct: 81 AARDVPEGMQNLAPNDLPL-LAMEYCQGGDLRKYLNQFENCCGLREGAILTLLS-DIASA 138 Query: 177 LTYLREKHKIMHRDVKPSNILVNSRGEIKLC----DFGVSGQLID-SMANSFVGTRSYMS 231 L YL E ++I+HRD+KP NI++ +GE +L D G + +L S+ SFVGT Y++ Sbjct: 139 LRYLHE-NRIIHRDLKPENIVLQ-QGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLA 196 Query: 232 PERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPP 265 PE L+ Y+V D WS G E G P P Sbjct: 197 PELLEQQKYTVTVDYWSFGTLAFECITGFRPFLP 230 >2OU7-A nrPDB Length = 335 Score = 81.6 bits (200), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 54/204 (26%), Positives = 101/204 (49%), Gaps = 5/204 (2%) Query: 74 LGAGNGGVVFKVSHKPSGLVMARKLI--HLEIKPAIRNQIIRELQVLHECNSPYIVGFYG 131 LG G F++S + V A K++ L +KP R ++ E+ + ++VGF+G Sbjct: 49 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 108 Query: 132 AFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDV 191 F + + + +E SL ++ K+ + E ++ G YL +++++HRD+ Sbjct: 109 FFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYL-HRNRVIHRDL 167 Query: 192 KPSNILVNSRGEIKLCDFGVSGQL--IDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSM 249 K N+ +N E+K+ DFG++ ++ GT +Y++PE L +S + D+WS+ Sbjct: 168 KLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGHSFEVDVWSI 227 Query: 250 GLSLVEMAVGRYPIPPPDAKELEL 273 G + + VG+ P KE L Sbjct: 228 GCIMYTLLVGKPPFETSCLKETYL 251 >2YAB-A nrPDB Length = 361 Score = 81.6 bits (200), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 59/211 (27%), Positives = 103/211 (48%), Gaps = 12/211 (5%) Query: 64 KDDDFEKI-SELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPA-----IRNQIIRELQV 117 K +DF I ELG+G +V K K +GL A K I A R +I RE+ + Sbjct: 9 KVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIEREVSI 68 Query: 118 LHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGL 177 L + P I+ + + + ++ + +E + GG L L + + E+ ++ G+ Sbjct: 69 LRQVLHPNIITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGV 128 Query: 178 TYLREKHKIMHRDVKPSNILVNSRG----EIKLCDFGVSGQLIDSMA-NSFVGTRSYMSP 232 YL K KI H D+KP NI++ + IKL DFG++ ++ D + + GT +++P Sbjct: 129 NYLHTK-KIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAP 187 Query: 233 ERLQGTHYSVQSDIWSMGLSLVEMAVGRYPI 263 E + +++D+WS+G+ + G P Sbjct: 188 EIVNYEPLGLEADMWSIGVITYILLSGASPF 218 >6BXI-A nrPDB Length = 333 Score = 81.6 bits (200), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 62/238 (26%), Positives = 107/238 (44%), Gaps = 45/238 (18%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE--IKPAIRNQIIRELQVLHECNS 123 +DFE + +G G G V V K +G V A K++ ++ I E +L E +S Sbjct: 6 EDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADS 65 Query: 124 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREK 183 ++V + +F + + ME + GG + +L K + E+ + + + + + Sbjct: 66 LWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEE---ETQFYIAETVLAIDSI 122 Query: 184 HKI--MHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS----------------------- 218 H++ +HRD+KP N+L++S+G +KL DFG+ L + Sbjct: 123 HQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMN 182 Query: 219 --------------MANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYP 262 +A S VGT Y++PE T Y+ D WS+G+ + EM +G YP Sbjct: 183 SKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIG-YP 239 >4J52-A nrPDB Length = 293 Score = 81.6 bits (200), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 54/204 (26%), Positives = 101/204 (49%), Gaps = 5/204 (2%) Query: 74 LGAGNGGVVFKVSHKPSGLVMARKLI--HLEIKPAIRNQIIRELQVLHECNSPYIVGFYG 131 LG G F++S + V A K++ L +KP R ++ E+ + ++VGF+G Sbjct: 22 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 81 Query: 132 AFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDV 191 F + + + +E SL ++ K+ + E ++ G YL +++++HRD+ Sbjct: 82 FFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYL-HRNRVIHRDL 140 Query: 192 KPSNILVNSRGEIKLCDFGVSGQL--IDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSM 249 K N+ +N E+K+ DFG++ ++ GT +Y++PE L +S + D+WS+ Sbjct: 141 KLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGHSFEVDVWSI 200 Query: 250 GLSLVEMAVGRYPIPPPDAKELEL 273 G + + VG+ P KE L Sbjct: 201 GCIMYTLLVGKPPFETSCLKETYL 224 >2OZO-A nrPDB Length = 613 Score = 81.3 bits (199), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 62/206 (30%), Positives = 107/206 (51%), Gaps = 25/206 (12%) Query: 73 ELGAGNGGVVFKVSHKPSGLVMARKLIHLEIK-------PAIRNQIIRELQVLHECNSPY 125 ELG GN G V + ++ M +K I + IK A +++RE Q++H+ ++PY Sbjct: 343 ELGCGNFGSVRQGVYR-----MRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPY 397 Query: 126 IVGFYGAFYSDGEISICMEHMDGGSLDQVL-KKAGRIPEQILGKVSIAVIKGLTYLREKH 184 IV G ++ + + ME GG L + L K IP + ++ V G+ YL EK+ Sbjct: 398 IVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKN 456 Query: 185 KIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRS-------YMSPERLQG 237 +HR++ N+L+ +R K+ DFG+S L +S+ RS + +PE + Sbjct: 457 -FVHRNLAARNVLLVNRHYAKISDFGLSKAL--GADDSYYTARSAGKWPLKWYAPECINF 513 Query: 238 THYSVQSDIWSMGLSLVE-MAVGRYP 262 +S +SD+WS G+++ E ++ G+ P Sbjct: 514 RKFSSRSDVWSYGVTMWEALSYGQKP 539 >3ORP-A nrPDB Length = 311 Score = 81.3 bits (199), Expect = 8e-16, Method: Compositional matrix adjust. Identities = 52/176 (29%), Positives = 87/176 (49%), Gaps = 18/176 (10%) Query: 101 LEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEIS--------ICMEHMDGGSLD 152 L P+ + RE Q N P IV A Y GE I ME++DG +L Sbjct: 49 LARDPSFYLRFRREAQNAAALNHPAIV----AVYDTGEAETPAGPLPYIVMEYVDGVTLR 104 Query: 153 QVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVS 212 ++ G + + +V + L + ++ I+HRDVKP+NI++++ +K+ DFG++ Sbjct: 105 DIVHTEGPMTPKRAIEVIADACQALNF-SHQNGIIHRDVKPANIMISATNAVKVMDFGIA 163 Query: 213 GQLIDS-----MANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPI 263 + DS + +GT Y+SPE+ +G +SD++S+G L E+ G P Sbjct: 164 RAIADSGNSVTQTAAVIGTAQYLSPEQARGDSVDARSDVYSLGCVLYEVLTGEPPF 219 >6CMJ-A nrPDB Length = 321 Score = 80.9 bits (198), Expect = 8e-16, Method: Compositional matrix adjust. Identities = 81/323 (25%), Positives = 140/323 (43%), Gaps = 69/323 (21%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRN------------QIIR 113 D + E+G G+ GVV ++ A K+ L K IR Q+ + Sbjct: 34 DQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKV--LSKKKLIRQAGGCIQPRGPIEQVYQ 91 Query: 114 ELQVLHECNSPYIVGFYGAFYSDGEISICM--EHMDGGSLDQV--LKKAGRIPEQILGKV 169 E+ +L + + P +V E + M E ++ G + +V LK + + Sbjct: 92 EIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQ- 150 Query: 170 SIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL--IDSMANSFVGTR 227 +IKG+ YL + KI+HRD+KPSN+LV G IK+ DFGVS + D++ ++ VGT Sbjct: 151 --DLIKGIEYLHYQ-KIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTP 207 Query: 228 SYMSPERLQGTH--YSVQS-DIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAA 284 ++M+PE L T +S ++ D+W+MG++L G+ P E + +++ A Sbjct: 208 AFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPF----MDERIMCLHSKIKSQAL 263 Query: 285 ETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIK 344 E P +P + + +D + + L K Sbjct: 264 EFPDQPD--------------------------------------IAEDLKDLITRMLDK 285 Query: 345 NPAERADLKQLMVHAFIKRSDAE 367 NP R + ++ +H ++ R AE Sbjct: 286 NPESRIVVPEIKLHPWVTRHGAE 308 >4PDS-A nrPDB Length = 347 Score = 80.9 bits (198), Expect = 8e-16, Method: Compositional matrix adjust. Identities = 82/316 (25%), Positives = 128/316 (40%), Gaps = 60/316 (18%) Query: 67 DFEKISEL-GAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPY 125 DF I E+ G G V K + +G + K+I + + REL+VL + N P Sbjct: 31 DFSIIDEVVGQGAFATVKKAIERTTGKTFSVKIISKRKVIGNMDGVTRELEVLQKLNHPR 90 Query: 126 IVGFYGAFYSDGE-ISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKH 184 IV G FY D E + ME + GG L + G + E ++S ++ + Y+ Sbjct: 91 IVRLKG-FYEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHS-M 148 Query: 185 KIMHRDVKPSNILVNSRGE--IKLCDFGVSG-QLIDSMANSFVGTRSYMSPERLQG---- 237 I HRD+KP NIL+ +K+ FG++ Q S +F GT +Y++PE ++G Sbjct: 149 GISHRDLKPDNILIEQDDPVLVKITAFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDTS 208 Query: 238 ---------THYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPP 288 YS D+WSMG + + G P +L G G E P Sbjct: 209 VSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIG---RGSYHEGP- 264 Query: 289 RPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAE 348 L D+ ++E E +DF++ L +P Sbjct: 265 ------------------------LKDFRISE------------EARDFIDSLLQVDPNN 288 Query: 349 RADLKQLMVHAFIKRS 364 R+ + + H +IK S Sbjct: 289 RSTAAKALNHPWIKMS 304 >1KOB-A nrPDB Length = 387 Score = 80.9 bits (198), Expect = 9e-16, Method: Compositional matrix adjust. Identities = 56/222 (25%), Positives = 109/222 (49%), Gaps = 7/222 (3%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPY 125 D ++ + ELG+G GVV + K +G V K I+ P + + E+ ++++ + P Sbjct: 51 DYYDILEELGSGAFGVVHRCVEKATGRVFVAKFINTPY-PLDKYTVKNEISIMNQLHHPK 109 Query: 126 IVGFYGAFYSDGEISICMEHMDGGSL-DQVLKKAGRIPEQILGKVSIAVIKGLTYLREKH 184 ++ + AF E+ + +E + GG L D++ + ++ E + +GL ++ E H Sbjct: 110 LINLHDAFEDKYEMVLILEFLSGGELFDRIAAEDYKMSEAEVINYMRQACEGLKHMHE-H 168 Query: 185 KIMHRDVKPSNILVNSR--GEIKLCDFGVSGQLI-DSMANSFVGTRSYMSPERLQGTHYS 241 I+H D+KP NI+ ++ +K+ DFG++ +L D + T + +PE + Sbjct: 169 SIVHLDIKPENIMCETKKASSVKIIDFGLATKLNPDEIVKVTTATAEFAAPEIVDREPVG 228 Query: 242 VQSDIWSMGLSLVEMAVGRYPIPPPDAKE-LELMFGCQVEGD 282 +D+W++G+ + G P D E L+ + C E D Sbjct: 229 FYTDMWAIGVLGYVLLSGLSPFAGEDDLETLQNVKRCDWEFD 270 >6FDY-U nrPDB Length = 276 Score = 80.9 bits (198), Expect = 9e-16, Method: Compositional matrix adjust. Identities = 60/212 (28%), Positives = 100/212 (47%), Gaps = 6/212 (2%) Query: 66 DDFEKISELGAGNGGVVFKV-SHKPSGLVMARKLIHLE-IKPAIRNQIIRELQVLHECNS 123 D F LG+G V+K + K + V+A K + + + A ++ E+++L Sbjct: 11 DGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKGIRH 70 Query: 124 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREK 183 P+IV + I + ME GG L + + +PE++ + L +L E+ Sbjct: 71 PHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFLHER 130 Query: 184 HKIMHRDVKPSNILVNS--RGEIKLCDFGVSGQLID-SMANSFVGTRSYMSPERLQGTHY 240 + I H D+KP NIL++S + +KL DFG + + + G+ YM+PE + Y Sbjct: 131 N-ISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMVCQRQY 189 Query: 241 SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELE 272 + D+WSMG+ L E G+ P ELE Sbjct: 190 DARVDLWSMGVILYEALFGQPPFASRSFSELE 221 >4QNY-A nrPDB Length = 354 Score = 80.9 bits (198), Expect = 9e-16, Method: Compositional matrix adjust. Identities = 80/310 (25%), Positives = 137/310 (44%), Gaps = 32/310 (10%) Query: 74 LGAGNGGVVFKVSH-KPSGLVMARKLIHLEI--KPAIRNQIIRELQVLHECNSPYIVGFY 130 +GAG+ GVV + K ++A K ++ EI + + +I+RE+++L N I+G Sbjct: 28 IGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFEEVILAKRILREIKLLAHFNDDNIIGLR 87 Query: 131 GAFYSDG-----EISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHK 185 + I M+ M+ L QVL+ + E + + + L L H Sbjct: 88 NILTPEDPENFDHFYIVMDIMET-DLKQVLRSGQELTE---AHIQFFIYQALRALHIIHS 143 Query: 186 --IMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS--MANSFVGTRSYMSPER-LQGTHY 240 ++HRD+ P+NILVN+ ++K+CDFG++ + D +V R Y +PE ++ Y Sbjct: 144 AGVIHRDITPANILVNTNCDLKICDFGLAKEENDQGEYMTDYVTMRWYRAPELVMEDKDY 203 Query: 241 SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY 300 S Q D+W +G L E+ +G P+ + +L V G +E Sbjct: 204 SAQIDVWGIGCILGEL-LGSRPLFQGKDRVNQLDKIVDVIGTPSEEDINSVGSSAAQKYL 262 Query: 301 GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF 360 S P A + + P+ S E D + L+ NP R + Q M H F Sbjct: 263 KKKSHRPQADWR----------QRYPTA--SPEALDLLRHMLVFNPKRRITVLQAMRHPF 310 Query: 361 IKR--SDAEE 368 +++ DA++ Sbjct: 311 LEQLHDDADD 320 >5AMN-A nrPDB Length = 299 Score = 80.9 bits (198), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 67/235 (28%), Positives = 113/235 (48%), Gaps = 29/235 (12%) Query: 73 ELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGA 132 E G F + + +A K++ P+ ++ E VL + N P+++ YGA Sbjct: 35 EFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGA 94 Query: 133 FYSDGEISICMEHMDGGSLDQVLKKAGRI----PEQ---ILGK-VSIA--VIKGLTYLRE 182 DG + + +E+ GSL L+++ ++ P++ +G +S A + +G+ YL E Sbjct: 95 CSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYPDERALTMGDLISFAWQISQGMQYLAE 154 Query: 183 KHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRS-------YMSPERL 235 K++HRD+ NILV ++K+ DFG+S + + +S+V RS +M+ E L Sbjct: 155 -MKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEE--DSYV-KRSQGRIPVKWMAIESL 210 Query: 236 QGTHYSVQSDIWSMGLSLVEMAV---GRYPIPPPDAKELELMFGCQVEGDAAETP 287 Y+ QSD+WS G+ L E+ YP PP E +F G E P Sbjct: 211 FDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPP-----ERLFNLLKTGHRMERP 260 >4Y93-A nrPDB Length = 446 Score = 80.9 bits (198), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 61/206 (29%), Positives = 102/206 (49%), Gaps = 9/206 (4%) Query: 62 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHEC 121 E+ D + ELG G GVV K +A K+I + ++ I E +V+ Sbjct: 184 EIDPKDLTFLKELGTGQFGVV-KYGKWRGQYDVAIKMI--KEGSMSEDEFIEEAKVMMNL 240 Query: 122 NSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKA-GRIPEQILGKVSIAVIKGLTYL 180 + +V YG I I E+M G L L++ R Q L ++ V + + YL Sbjct: 241 SHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYL 300 Query: 181 REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTR---SYMSPERLQG 237 E + +HRD+ N LVN +G +K+ DFG++ ++D S G++ + SPE L Sbjct: 301 -ESKQFLHRDLAARNCLVNDQGVVKVSDFGMTRYVLDDEYTSSTGSKFPVKWASPEVLMY 359 Query: 238 THYSVQSDIWSMGLSLVEM-AVGRYP 262 + +S +SDIW+ G+ + E+ ++G+ P Sbjct: 360 SKFSSKSDIWAFGVLMWEIYSLGKMP 385 >2J90-A nrPDB Length = 304 Score = 80.9 bits (198), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 74/310 (23%), Positives = 129/310 (41%), Gaps = 55/310 (17%) Query: 65 DDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEI-----KPAIRNQIIRELQVLH 119 +D +E ELG+G +V K K +G A K I + R +I RE+ +L Sbjct: 25 EDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILR 84 Query: 120 ECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTY 179 E P I+ + F + ++ + +E + GG L L + + E + ++ G+ Y Sbjct: 85 EIRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDGVHY 144 Query: 180 LREKHKIMHRDVKPSNILVNSRG----EIKLCDFGVSGQLIDSMANSF---VGTRSYMSP 232 L K +I H D+KP NI++ + IKL DFG++ ++ N F GT +++P Sbjct: 145 LHSK-RIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKI--EAGNEFKNIFGTPEFVAP 201 Query: 233 ERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRT 292 E + +++D+WS+G+ + G P ET T Sbjct: 202 EIVNYEPLGLEADMWSIGVITYILLSGASPF-------------------LGETKQETLT 242 Query: 293 PGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADL 352 + +Y D +Y N +DF+ + L+K+P R + Sbjct: 243 NISAV-NYDFDE----------EYFSNTSELA----------KDFIRRLLVKDPKRRMTI 281 Query: 353 KQLMVHAFIK 362 Q + H++IK Sbjct: 282 AQSLEHSWIK 291 >4YFF-A nrPDB Length = 311 Score = 80.5 bits (197), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 61/210 (29%), Positives = 107/210 (50%), Gaps = 11/210 (5%) Query: 62 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHEC 121 +L + +F +I +G+G+ G V+K + + + R + + + RE+ +L + Sbjct: 40 QLSEIEFHEI--IGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSDVDMFCREVSILCQL 97 Query: 122 NSPYIVGFYGAFYSD-GEISICMEHMDGGSLDQVLKKAGRIPE-QILGKVSIAVIKGLTY 179 N P ++ F GA +D + +I +++ GGSL +L + RI + Q +++ V KG+ Y Sbjct: 98 NHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEY 157 Query: 180 LRE-KHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLI----DSMANSFVGTRSYMSPER 234 L I+HRD+ NIL+ G + DFG S L D+M G +M+PE Sbjct: 158 LHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQ-PGNLRWMAPEV 216 Query: 235 L-QGTHYSVQSDIWSMGLSLVEMAVGRYPI 263 Q T Y++++D++S L L E+ G P Sbjct: 217 FTQCTRYTIKADVFSYALCLWEILTGEIPF 246 >4Y83-A nrPDB Length = 332 Score = 80.5 bits (197), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 57/170 (33%), Positives = 89/170 (52%), Gaps = 24/170 (14%) Query: 101 LEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR 160 +EI+ R++ I EL YGA + + ME +GGS+ + L+ G Sbjct: 116 VEIQACFRHENIAEL--------------YGAVLWGETVHLFMEAGEGGSVLEKLESCGP 161 Query: 161 IPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA 220 + E + V+ V+KGL +L K K++H D+KPSNI+ S + L DFG+S Q+ + + Sbjct: 162 MREFEIIWVTKHVLKGLDFLHSK-KVIHHDIKPSNIVFMSTKAV-LVDFGLSVQMTEDVY 219 Query: 221 --NSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVG------RYP 262 GT YMSPE + +S ++DI+S+G +L+ M G RYP Sbjct: 220 FPKDLRGTEIYMSPEVILCRGHSTKADIYSLGATLIHMQTGTPPWVKRYP 269 >4E7W-A nrPDB Length = 394 Score = 80.5 bits (197), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 62/224 (27%), Positives = 109/224 (48%), Gaps = 29/224 (12%) Query: 54 LTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIR 113 L K GE ++ + +G G+ GVVF+ S V +K++ +N R Sbjct: 28 LASDGKTGEQREIAYTNCKVIGNGSFGVVFQAKLVESDEVAIKKVLQ---DKRFKN---R 81 Query: 114 ELQVLHECNSPYIVGFYGAFYSDGE------ISICMEHMDGGSLDQVLKKAGR------- 160 ELQ++ P +V FYS+G+ +++ +E++ + + +A R Sbjct: 82 ELQIMRIVKHPNVVDLKAFFYSNGDKKDEVFLNLVLEYVP-----ETVYRASRHYAKLKQ 136 Query: 161 -IPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNS-RGEIKLCDFGVSGQLIDS 218 +P ++ +++ L Y+ I HRD+KP N+L++ G +KL DFG + LI Sbjct: 137 TMPMLLIKLYMYQLLRSLAYIHSI-GICHRDIKPQNLLLDPPSGVLKLIDFGSAKILIAG 195 Query: 219 MAN-SFVGTRSYMSPERLQG-THYSVQSDIWSMGLSLVEMAVGR 260 N S++ +R Y +PE + G T+Y+ DIWS G + E+ G+ Sbjct: 196 EPNVSYICSRYYRAPELIFGATNYTTNIDIWSTGCVMAELMQGQ 239 >3NYO-A nrPDB Length = 576 Score = 80.1 bits (196), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 57/207 (27%), Positives = 99/207 (47%), Gaps = 14/207 (6%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQI--IRELQVLHECNS 123 + F + LG G G V + +G + A K + + + + + E Q+L + NS Sbjct: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNS 243 Query: 124 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR--IPEQILGKVSIAVIKGLTYLR 181 ++V A+ + + + + M+GG L + G+ PE + + GL L Sbjct: 244 RFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDL- 302 Query: 182 EKHKIMHRDVKPSNILVNSRGEIKLCDFGVS-----GQLIDSMANSFVGTRSYMSPERLQ 236 + +I++RD+KP NIL++ G I++ D G++ GQ I VGT YM+PE ++ Sbjct: 303 HRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGR----VGTVGYMAPEVVK 358 Query: 237 GTHYSVQSDIWSMGLSLVEMAVGRYPI 263 Y+ D W++G L EM G+ P Sbjct: 359 NERYTFSPDWWALGCLLYEMIAGQSPF 385 >5AIR-A nrPDB Length = 430 Score = 80.1 bits (196), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 86/322 (26%), Positives = 146/322 (45%), Gaps = 61/322 (18%) Query: 74 LGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAF 133 +G G+ GVV++ SG ++A K + + + +N RELQ++ + + IV F Sbjct: 72 IGNGSFGVVYQAKLCDSGELVAIKKVLQDKR--FKN---RELQIMRKLDHCNIVRLRYFF 126 Query: 134 YSDGE------ISICMEHMDGGSLDQVLKKAGR----IPEQILGKVSIAVIKGLTYLREK 183 YS GE +++ ++++ ++ +V + R +P + + + L Y+ Sbjct: 127 YSSGEKKDEVYLNLVLDYVPE-TVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYI-HS 184 Query: 184 HKIMHRDVKPSNILVN-SRGEIKLCDFGVSGQLIDSMAN-SFVGTRSYMSPERLQG-THY 240 I HRD+KP N+L++ +KLCDFG + QL+ N S++ +R Y +PE + G T Y Sbjct: 185 FGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDY 244 Query: 241 SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPR----------- 289 + D+WS G L E+ +G+ PI P D+ +L+ +V G TP R Sbjct: 245 TSSIDVWSAGCVLAELLLGQ-PIFPGDSGVDQLVEIIKVLG----TPTREQIREMNPNYT 299 Query: 290 ----PRTPGRPLSSYGMDSRPPMAIF---ELLDYI------------------VNEPPPK 324 P+ P + PP AI LL+Y + +P K Sbjct: 300 EFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVK 359 Query: 325 LPSGVFSLEFQDFVNKCLIKNP 346 LP+G + +F + L NP Sbjct: 360 LPNGRDTPALFNFTTQELSSNP 381 >4IC8-A nrPDB Length = 442 Score = 80.1 bits (196), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 73/276 (26%), Positives = 122/276 (44%), Gaps = 47/276 (17%) Query: 6 PTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELKD 65 P P++ PA ++V A NL L+ + ++ D VG Sbjct: 20 PGPVKAEPAHTAASV-----AAKNLALLKARSFDVTFD----------------VG---- 54 Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIR-NQIIRELQVLHECNSP 124 D++E I +G G GVV + +G +A K I + +REL++L Sbjct: 55 DEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHD 114 Query: 125 YIVGF---------YGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIK 175 I+ YG F S + + ++ M+ L Q++ + + + + +++ Sbjct: 115 NIIAIKDILRPTVPYGEFKS---VYVVLDLMES-DLHQIIHSSQPLTLEHVRYFLYQLLR 170 Query: 176 GLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA------NSFVGTRSY 229 GL Y+ +++HRD+KPSN+LVN E+K+ DFG++ L S A +V TR Y Sbjct: 171 GLKYMHSA-QVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWY 229 Query: 230 MSPERLQGTH-YSVQSDIWSMGLSLVEMAVGRYPIP 264 +PE + H Y+ D+WS+G EM R P Sbjct: 230 RAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFP 265 >5TOS-A nrPDB Length = 395 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 65/217 (29%), Positives = 110/217 (50%), Gaps = 19/217 (8%) Query: 62 ELKDDDFEKISELGAGNGGVVFK--------VSHKP-SGLVMARKLIHLEIKPAIRNQII 112 +L +F S +G G G VFK KP +GLV+A K ++ E R + + Sbjct: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHR-EWL 119 Query: 113 RELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR----IPEQILGK 168 E+ L + + P +V G D + E M GSL+ L + G +P + Sbjct: 120 TEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVN 179 Query: 169 VSIAVIKGLTYLR-EKHKIMHRDVKPSNILVNSRGEIKLCDFGVS--GQLID--SMANSF 223 V++ KGL +L + K+++RD+K SNIL+++ KL DFG++ G + D ++ Sbjct: 180 VALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRV 239 Query: 224 VGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGR 260 +GT Y +PE + H + +SD++S G+ L+E+ G+ Sbjct: 240 MGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGK 276 >2W1I-A nrPDB Length = 326 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 61/198 (30%), Positives = 98/198 (49%), Gaps = 14/198 (7%) Query: 71 ISELGAGNGGVVFKVSHKP----SGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYI 126 + +LG GN G V + P +G V+A K + + +R+ RE+++L I Sbjct: 46 LQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRD-FEREIEILKSLQHDNI 104 Query: 127 VGFYGAFYSDGE--ISICMEHMDGGSL-DQVLKKAGRIPEQILGKVSIAVIKGLTYLREK 183 V + G YS G + + ME++ GSL D + K RI L + + + KG+ YL K Sbjct: 105 VKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTK 164 Query: 184 HKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRS-----YMSPERLQGT 238 + +HRD+ NILV + +K+ DFG++ L V + +PE L + Sbjct: 165 -RYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTES 223 Query: 239 HYSVQSDIWSMGLSLVEM 256 +SV SD+WS G+ L E+ Sbjct: 224 KFSVASDVWSFGVVLYEL 241 >5UIU-A nrPDB Length = 323 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 59/200 (29%), Positives = 108/200 (54%), Gaps = 18/200 (9%) Query: 72 SELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPA-IRNQIIRELQVLHECNSPYIVGFY 130 +++G G GVV+K + + + + ++I ++ Q +E++V+ +C +V Sbjct: 53 NKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELL 112 Query: 131 GAFYSDGEISICMEHM---DGGSLDQVLKKAGRIP--EQILGKVSIAVIKGLTYLREKHK 185 G F SDG+ +C+ ++ +G LD++ G P + K++ G+ +L E H Sbjct: 113 G-FSSDGD-DLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHH 170 Query: 186 IMHRDVKPSNILVNSRGEIKLCDFGVS------GQLIDSMANSFVGTRSYMSPERLQGTH 239 I HRD+K +NIL++ K+ DFG++ Q + M + VGT +YM+PE L+G Sbjct: 171 I-HRDIKSANILLDEAFTAKISDFGLARASEKFAQTV--MTSRIVGTTAYMAPEALRG-E 226 Query: 240 YSVQSDIWSMGLSLVEMAVG 259 + +SDI+S G+ L+E+ G Sbjct: 227 ITPKSDIYSFGVVLLEIITG 246 >3TAC-A nrPDB Length = 361 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 86/324 (26%), Positives = 141/324 (43%), Gaps = 61/324 (18%) Query: 61 GELKDDD--FEKISEL----GAGNGGVVFKVSHKPSGLVMARKLI---HLEIKPAIRNQ- 110 G + DDD FE + EL G G VV + ++ +G A K++ P + + Sbjct: 15 GSMADDDVLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTED 74 Query: 111 IIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLD-QVLKKAGR---IPEQIL 166 + RE + H P+IV + SDG + + E MDG L +++K+A E + Sbjct: 75 LKREASICHMLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVA 134 Query: 167 GKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSR---GEIKLCDFGVSGQLIDS--MAN 221 +++ L Y + + I+HRDVKP +L+ S+ +KL FGV+ QL +S +A Sbjct: 135 SHYMRQILEALRYCHD-NNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAG 193 Query: 222 SFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEG 281 VGT +M+PE ++ Y D+W G+ L L+ GC Sbjct: 194 GRVGTPHFMAPEVVKREPYGKPVDVWGCGVIL-----------------FILLSGC---- 232 Query: 282 DAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKC 341 L YG R +FE + + P+ S + S +D V + Sbjct: 233 ---------------LPFYGTKER----LFEGIIKGKYKMNPRQWSHI-SESAKDLVRRM 272 Query: 342 LIKNPAERADLKQLMVHAFIKRSD 365 L+ +PAER + + + H ++K D Sbjct: 273 LMLDPAERITVYEALNHPWLKERD 296 >5IG1-A nrPDB Length = 344 Score = 79.3 bits (194), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 62/226 (27%), Positives = 107/226 (47%), Gaps = 8/226 (3%) Query: 62 ELKDDDF-EKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE-IKPAIRNQIIRELQVLH 119 +L D D +K S +G G V + +K +G V A K+I L+ ++ + N+I RE+ + Sbjct: 12 DLYDVDLKDKRSVIGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRSSEINKIKREIGICS 71 Query: 120 ECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTY 179 +IV AF + + E++ GG L + E+ ++ L + Sbjct: 72 SLQHEHIVSMRRAFRDESHFYLVFEYVSGGELFDEIVTRKFYNEKDASACMHQILSALQH 131 Query: 180 LREKHKIMHRDVKPSNILVNSR---GEIKLCDFGVSGQLIDS-MANSFVGTRSYMSPERL 235 K+ I+HRD+KP N+L+ S+ +K+ DFG++ + F GT Y+SPE + Sbjct: 132 CHSKN-IIHRDLKPENLLLASKDPNAPVKITDFGLAVIMEQGPTYFGFAGTPGYLSPEVI 190 Query: 236 QGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMF-GCQVE 280 + Y D+W+ G+ L + VG P D ++L CQ + Sbjct: 191 RRVPYDTAVDVWACGVILYILLVGYPPFWEEDHQKLYAQIKNCQYD 236 >2H34-A nrPDB Length = 309 Score = 79.3 bits (194), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 65/233 (27%), Positives = 108/233 (46%), Gaps = 18/233 (7%) Query: 74 LGAGNGGVVFKVSHKPSGLVMARKLIH--LEIKPAIRNQIIRELQVLHECNSPYIVGFYG 131 +G G G V++ ++A KL+ L P R ++ RE + P++V + Sbjct: 42 VGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPVFRTRMQREARTAGRLQEPHVVPIHD 101 Query: 132 AFYSDGEISICMEHMDGGSLDQVLKKAGRI-PEQILGKVSIAVIKGLTYLREKHKIMHRD 190 DG++ + M ++G L +L++ G + P + + V I HRD Sbjct: 102 FGEIDGQLYVDMRLINGVDLAAMLRRQGPLAPPRAVAIVR--QIGSALDAAHAAGATHRD 159 Query: 191 VKPSNILVNSRGEIKLCDFGVSGQLID---SMANSFVGTRSYMSPERLQGTHYSVQSDIW 247 VKP NILV++ L DFG++ D + + VGT YM+PER +H + ++DI+ Sbjct: 160 VKPENILVSADDFAYLVDFGIASATTDEKLTQLGNTVGTLYYMAPERFSESHATYRADIY 219 Query: 248 SMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRT--PGRPLS 298 ++ L E G PP +L +M G + + PRP T PG P++ Sbjct: 220 ALTCVLYECLTGS---PPYQGDQLSVM-GAHIN----QAIPRPSTVRPGIPVA 264 >3GUB-A nrPDB Length = 295 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 73/322 (22%), Positives = 135/322 (41%), Gaps = 55/322 (17%) Query: 65 DDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE-----IKPAIRNQIIRELQVLH 119 DD ++ ELG+G VV K K +GL A K I + R I RE+ +L Sbjct: 10 DDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILK 69 Query: 120 ECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTY 179 E P ++ + + + ++ + E + GG L L + + E+ + ++ G+ Y Sbjct: 70 EIQHPNVITLHEVYENKTDVILIGELVAGGELFDFLAEKESLTEEEATEFLKQILNGVYY 129 Query: 180 LREKHKIMHRDVKPSNILVNSRG----EIKLCDFGVSGQLIDSMANSF---VGTRSYMSP 232 L +I H D+KP NI++ R IK+ DFG++ ++ N F GT +++P Sbjct: 130 LH-SLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKI--DFGNEFKNIFGTPEFVAP 186 Query: 233 ERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRT 292 E + +++D+WS+G+ + G P Sbjct: 187 EIVNYEPLGLEADMWSIGVITYILLSGASPF----------------------------- 217 Query: 293 PGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADL 352 G + +A ++Y E + S +L +DF+ + L+K+P +R + Sbjct: 218 -------LGDTKQETLANVSAVNY---EFEDEYFSNTSALA-KDFIRRLLVKDPKKRMTI 266 Query: 353 KQLMVHAFIKRSDAEEVDFAGW 374 + + H +IK D ++ + W Sbjct: 267 QDSLQHPWIKPKDTQQALSSAW 288 >5O0Y-A nrPDB Length = 579 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 61/208 (29%), Positives = 96/208 (46%), Gaps = 20/208 (9%) Query: 102 EIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISIC--MEHMDGGSLDQVLKKAG 159 E K RE ++ E + P IV Y F D + S C +E+ +G LD LK+ Sbjct: 326 EKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTD-SFCTVLEYCEGNDLDFYLKQHK 384 Query: 160 RIPEQILGKVSIAVIKGLTYLRE-KHKIMHRDVKPSNILV---NSRGEIKLCDFGVSGQL 215 + E+ + + ++ L YL E K I+H D+KP NIL+ + GEIK+ DFG+S + Sbjct: 385 LMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIM 444 Query: 216 IDSMANSF---------VGTRSYMSPERL----QGTHYSVQSDIWSMGLSLVEMAVGRYP 262 D NS GT Y+ PE + S + D+WS+G+ + GR P Sbjct: 445 DDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKP 504 Query: 263 IPPPDAKELELMFGCQVEGDAAETPPRP 290 +++ L ++ + PP+P Sbjct: 505 FGHNQSQQDILQENTILKATEVQFPPKP 532 >4XI2-A nrPDB Length = 446 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 62/206 (30%), Positives = 101/206 (49%), Gaps = 9/206 (4%) Query: 62 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHEC 121 E+ D + ELG G GVV K +A K+I ++ I E +V+ Sbjct: 183 EIDPKDLTFLKELGTGQFGVV-KYGKWRGQYDVAIKMIRE--GSMSEDEFIEEAKVMMNL 239 Query: 122 NSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKA-GRIPEQILGKVSIAVIKGLTYL 180 + +V YG I I E+M G L L++ R Q L ++ V + + YL Sbjct: 240 SHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYL 299 Query: 181 REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTR---SYMSPERLQG 237 K + +HRD+ N LVN +G +K+ DFG+S ++D S VG++ + PE L Sbjct: 300 ESK-QFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMY 358 Query: 238 THYSVQSDIWSMGLSLVEM-AVGRYP 262 + +S +SDIW+ G+ + E+ ++G+ P Sbjct: 359 SKFSSKSDIWAFGVLMWEIYSLGKMP 384 >5YKS-A nrPDB Length = 377 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 56/211 (26%), Positives = 104/211 (49%), Gaps = 7/211 (3%) Query: 74 LGAGNGGVVFKVSHKPSGLVMARKLI-HLEIKPAIRNQIIRELQVLHECNSPYIVGFYGA 132 LG G+ VV H +G +A K+I ++ + +E++ + P IV Y Sbjct: 43 LGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHPNIVRLYEV 102 Query: 133 FYSDGEISICMEHMDGGSL-DQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDV 191 + ++ + +E DGG + D ++K + E + K ++ ++Y + H ++HRD+ Sbjct: 103 IDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLH-VVHRDL 161 Query: 192 KPSNIL-VNSRGEIKLCDFGVSGQLI-DSMANSFVGTRSYMSPERLQGTHYSVQS-DIWS 248 KP N++ +G +KL DFG S + + G+ +Y +PE L G Y + DIWS Sbjct: 162 KPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDAPAVDIWS 221 Query: 249 MGLSLVEMAVGRYPIPPP-DAKELELMFGCQ 278 +G+ L + G+ P D++ L ++ C+ Sbjct: 222 LGVILFMLVCGQPPFQEANDSETLTMIMDCK 252 >4PWN-A nrPDB Length = 274 Score = 79.0 bits (193), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 79/312 (25%), Positives = 137/312 (43%), Gaps = 51/312 (16%) Query: 60 VGELKDDDFEKIS-ELGAGNGGVVFK-VSHKPSGLVMARKLIHLEIKPAIRNQIIRELQV 117 VG D F K E+G G+ V+K + + + V +L ++ + R + E ++ Sbjct: 3 VGMSNDGRFLKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEM 62 Query: 118 LHECNSPYIVGFYGAFYSDGEISICM----EHMDGGSLDQVLKKAGRIPEQILGKVSIAV 173 L P IV FY ++ S + C+ E M G+L LK+ + ++L + Sbjct: 63 LKGLQHPNIVRFYDSWESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQI 122 Query: 174 IKGLTYLREKHK-IMHRDVKPSNILVNS-RGEIKLCDFGVSG-QLIDSMANSFVGTRSYM 230 +KGL +L + I+HRD+K NI + G +K+ D G++ + S A S +GT +M Sbjct: 123 LKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLEKRASFAKSVIGTPEFM 182 Query: 231 SPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRP 290 +PE + Y D+++ G+ ++EMA YP CQ +AA+ R Sbjct: 183 APEMYE-EKYDESVDVYAFGMCMLEMATSEYPYSE-----------CQ---NAAQIYRRV 227 Query: 291 RTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERA 350 + +P S D + +P E ++ + C+ +N ER Sbjct: 228 TSGVKPAS---------------FDKVA------IP------EVKEIIEGCIRQNKDERY 260 Query: 351 DLKQLMVHAFIK 362 +K L+ HAF + Sbjct: 261 SIKDLLNHAFFQ 272 >3C51-A nrPDB Length = 543 Score = 79.0 bits (193), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 62/228 (27%), Positives = 111/228 (48%), Gaps = 21/228 (9%) Query: 46 QRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKP 105 Q K LEA Q +GE D F LG G G VF K +G + A K ++ + Sbjct: 173 QWKWLEA-----QPMGE---DWFLDFRVLGRGGFGEVFACQMKATGKLYACKKLNKKRLK 224 Query: 106 AIRNQ--IIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAG---- 159 + + E ++L + +S +IV AF + ++ + M M+GG + + Sbjct: 225 KRKGYQGAMVEKKILAKVHSRFIVSLAYAFETKTDLCLVMTIMNGGDIRYHIYNVDEDNP 284 Query: 160 --RIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLI- 216 + P I + ++ GL +L +++ I++RD+KP N+L++ G +++ D G++ +L Sbjct: 285 GFQEPRAIF--YTAQIVSGLEHLHQRN-IIYRDLKPENVLLDDDGNVRISDLGLAVELKA 341 Query: 217 -DSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPI 263 + + GT +M+PE L G Y D +++G++L EM R P Sbjct: 342 GQTKTKGYAGTPGFMAPELLLGEEYDFSVDYFALGVTLYEMIAARGPF 389 >4ZSG-A nrPDB Length = 347 Score = 79.0 bits (193), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 61/216 (28%), Positives = 102/216 (47%), Gaps = 22/216 (10%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIR-NQIIRELQVLHECNSP 124 D++E I +G G GVV + +G +A K I + +REL++L Sbjct: 7 DEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHD 66 Query: 125 YIVGF---------YGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIK 175 I+ YG F S + + ++ M+ L Q++ + + + + +++ Sbjct: 67 NIIAIKDILRPTVPYGEFKS---VYVVLDLMES-DLHQIIHSSQPLTLEHVRYFLYQLLR 122 Query: 176 GLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA------NSFVGTRSY 229 GL Y+ +++HRD+KPSN+LVN E+K+ DFG++ L S A +V TR Y Sbjct: 123 GLKYMHSA-QVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWY 181 Query: 230 MSPERLQGTH-YSVQSDIWSMGLSLVEMAVGRYPIP 264 +PE + H Y+ D+WS+G EM R P Sbjct: 182 RAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFP 217 >6DTL-A nrPDB Length = 364 Score = 79.0 bits (193), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 59/210 (28%), Positives = 105/210 (50%), Gaps = 25/210 (11%) Query: 71 ISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQI-----IRELQVLHECNSPY 125 I +G G G+V + + +A K +I A N+I +RE+++L + Sbjct: 35 IMPIGKGAYGIVCSAMNSETNESVAIK----KIANAFDNKIDAKRTLREIKLLRHMDHEN 90 Query: 126 IVG--------FYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGL 177 IV AF ++ I E MD L Q+++ + E+ +++GL Sbjct: 91 IVAIRDIIPPPLRNAF---NDVYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQILRGL 146 Query: 178 TYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS-MANSFVGTRSYMSPE-RL 235 Y+ + ++HRD+KPSN+L+N+ ++K+CDFG++ +S +V TR Y +PE L Sbjct: 147 KYIHSAN-VLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLL 205 Query: 236 QGTHYSVQSDIWSMGLSLVEMAVGRYPIPP 265 + Y+ D+WS+G +E+ + R P+ P Sbjct: 206 NSSDYTAAIDVWSVGCIFMEL-MDRKPLFP 234 >5J0A-A nrPDB Length = 300 Score = 79.0 bits (193), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 58/213 (27%), Positives = 111/213 (52%), Gaps = 22/213 (10%) Query: 71 ISELGAGNGGVVF-------KVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNS 123 + +LG G G V+ +SH P + + + + + +++ E ++L + Sbjct: 14 MQKLGFGTGVNVYLMKRSPRGLSHSPWAVKKINPICNDHYRSVYQKRLMDEAKILKSLHH 73 Query: 124 PYIVGFYGAFY--SDGEISICMEHMDGGSLDQVLKKAGR-----IPEQILGKVSIAVIKG 176 P IVG Y AF +DG + + ME+ SL+ ++++ + P I+ KV++ + +G Sbjct: 74 PNIVG-YRAFTEANDGSLCLAMEYGGEKSLNDLIEERYKASQDPFPAAIILKVALNMARG 132 Query: 177 LTYLREKHKIMHRDVKPSNILVNSRGE-IKLCDFGVSGQLIDSMANS-----FVGTRSYM 230 L YL ++ K++H D+K SN+++ E IK+CD GVS L ++M + ++GT + Sbjct: 133 LKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMEVTDPEACYIGTEPWK 192 Query: 231 SPERLQGTHY-SVQSDIWSMGLSLVEMAVGRYP 262 E ++ + ++DI++ GL+L EM P Sbjct: 193 PKEAVEENGVITDKADIFAFGLTLWEMMTLSIP 225 >4EQM-A nrPDB Length = 294 Score = 78.6 bits (192), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 53/208 (25%), Positives = 103/208 (49%), Gaps = 6/208 (2%) Query: 60 VGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHL--EIKPAIRNQIIRELQV 117 +G++ ++ ++ + +LG G V+ + +A K I + K + RE+ Sbjct: 5 IGKIINERYKIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETLKRFEREVHN 64 Query: 118 LHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGL 177 + + IV D + ME+++G +L + ++ G + + ++ G+ Sbjct: 65 SSQLSHQNIVSMIDVDEEDDCYYLVMEYIEGPTLSEYIESHGPLSVDTAINFTNQILDGI 124 Query: 178 TYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID---SMANSFVGTRSYMSPER 234 + + +I+HRD+KP NIL++S +K+ DFG++ L + + N +GT Y SPE+ Sbjct: 125 KHAHDM-RIVHRDIKPQNILIDSNKTLKIFDFGIAKALSETSLTQTNHVLGTVQYFSPEQ 183 Query: 235 LQGTHYSVQSDIWSMGLSLVEMAVGRYP 262 +G +DI+S+G+ L EM VG P Sbjct: 184 AKGEATDECTDIYSIGIVLYEMLVGEPP 211 >6E4F-A nrPDB Length = 290 Score = 78.6 bits (192), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 62/206 (30%), Positives = 102/206 (49%), Gaps = 9/206 (4%) Query: 62 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHEC 121 E+ D + ELG G GVV K +A K+I + ++ I E +V+ Sbjct: 27 EIDPKDLTFLKELGTGQFGVV-KYGKWRGQYDVAIKMI--KEGSMSEDEFIEEAKVMMNL 83 Query: 122 NSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKA-GRIPEQILGKVSIAVIKGLTYL 180 + +V YG I I E+M G L L++ R Q L ++ V + + YL Sbjct: 84 SHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYL 143 Query: 181 REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTR---SYMSPERLQG 237 K + +HRD+ N LVN +G +K+ DFG+S ++D S VG++ + PE L Sbjct: 144 ESK-QFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMY 202 Query: 238 THYSVQSDIWSMGLSLVEM-AVGRYP 262 + +S +SDIW+ G+ + E+ ++G+ P Sbjct: 203 SKFSSKSDIWAFGVLMWEIYSLGKMP 228 >4CZT-A nrPDB Length = 464 Score = 78.6 bits (192), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 56/205 (27%), Positives = 98/205 (47%), Gaps = 8/205 (3%) Query: 74 LGAGNGGVVFKVSHKPSGLVMARKLIHLE--IKPAIRNQIIRELQVLHECNSPYIVGFYG 131 LG G V + +G +A K+I E +K + QI RE+ + P ++ + Sbjct: 19 LGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFE 78 Query: 132 AFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDV 191 S +I +E + GG L + GR+ E K +I + Y + + HRD+ Sbjct: 79 VMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRG-VYHRDL 137 Query: 192 KPSNILVNSRGEIKLCDFGVSG--QLI--DSMANSFVGTRSYMSPERLQGTHYS-VQSDI 246 KP N+L+++ G +K+ DFG+S Q + D + ++ GT +Y++PE + Y ++D+ Sbjct: 138 KPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADL 197 Query: 247 WSMGLSLVEMAVGRYPIPPPDAKEL 271 WS G+ L + G P + L Sbjct: 198 WSCGVILFVLMAGYLPFEDSNLTSL 222 >3IO7-A nrPDB Length = 313 Score = 78.6 bits (192), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 61/198 (30%), Positives = 98/198 (49%), Gaps = 14/198 (7%) Query: 71 ISELGAGNGGVVFKVSHKP----SGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYI 126 + +LG GN G V + P +G V+A K + + +R+ RE+++L I Sbjct: 33 LQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRD-FEREIEILKSLQHDNI 91 Query: 127 VGFYGAFYSDGE--ISICMEHMDGGSL-DQVLKKAGRIPEQILGKVSIAVIKGLTYLREK 183 V + G YS G + + ME++ GSL D + K RI L + + + KG+ YL K Sbjct: 92 VKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTK 151 Query: 184 HKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRS-----YMSPERLQGT 238 + +HRD+ NILV + +K+ DFG++ L V + +PE L + Sbjct: 152 -RYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTES 210 Query: 239 HYSVQSDIWSMGLSLVEM 256 +SV SD+WS G+ L E+ Sbjct: 211 KFSVASDVWSFGVVLYEL 228 >2WTK-B nrPDB Length = 373 Score = 78.6 bits (192), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 83/328 (25%), Positives = 137/328 (41%), Gaps = 47/328 (14%) Query: 68 FEKISELGAG--NGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIR----ELQVLHEC 121 +E ++ +G G + V +KP+G + + I+LE A N+++ EL V Sbjct: 11 YELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLE---ACSNEMVTFLQGELHVSKLF 67 Query: 122 NSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVL--KKAGRIPEQILGKVSIAVIKGLTY 179 N P IV + F +D E+ + M GS ++ + E + + V+K L Y Sbjct: 68 NHPNIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALDY 127 Query: 180 LREKHKIMHRDVKPSNILVNSRGEIKLCDF---------GVSGQLIDSMANSFVGTRSYM 230 + + HR VK S+IL++ G++ L G +++ V ++ Sbjct: 128 IHHMGYV-HRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSVKVLPWL 186 Query: 231 SPERLQGT--HYSVQSDIWSMGLSLVEMAVGRYPIP--PPDAKELELMFG---CQVEGDA 283 SPE LQ Y +SDI+S+G++ E+A G P P LE + G C ++ Sbjct: 187 SPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPCLLDTST 246 Query: 284 AETPPRPRTPGRPLSSYGMDS-------RPPMAIFELLDYIVNEPPPKLPSG-VFSLEFQ 335 +P R +++ G+ RP N P P FS F Sbjct: 247 IPAEELTMSPSRSVANSGLSDSLTTSTPRPS-----------NGDSPSHPYHRTFSPHFH 295 Query: 336 DFVNKCLIKNPAERADLKQLMVHAFIKR 363 FV +CL +NP R L+ H+F K+ Sbjct: 296 HFVEQCLQRNPDARPSASTLLNHSFFKQ 323 >3GC9-A nrPDB Length = 370 Score = 78.6 bits (192), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 66/260 (25%), Positives = 113/260 (43%), Gaps = 28/260 (10%) Query: 113 RELQVLHECNSPYIVGFYGAFYSDGEIS-----ICMEHMDGGSLDQVLKKAGRIPEQILG 167 REL++L ++G F I + + G L+ ++K E + Sbjct: 76 RELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKSQALSDEHVQF 135 Query: 168 KVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTR 227 V +++GL Y+ I+HRD+KPSN+ VN E+++ DFG++ Q + M +V TR Sbjct: 136 LV-YQLLRGLKYIHSA-GIIHRDLKPSNVAVNEDSELRILDFGLARQADEEM-TGYVATR 192 Query: 228 SYMSPE-RLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAET 286 Y +PE L HY+ DIWS+G + E+ G+ P D + +L +V G Sbjct: 193 WYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYID-QLKRIMEVVG----- 246 Query: 287 PPRPRTPGRPLSSYG---MDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLI 343 P P + S + + S PPM +L P + D + + L+ Sbjct: 247 TPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAI----------DLLGRMLV 296 Query: 344 KNPAERADLKQLMVHAFIKR 363 + +R + + HA+ + Sbjct: 297 LDSDQRVSAAEALAHAYFSQ 316 >5YV8-A nrPDB Length = 298 Score = 78.2 bits (191), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 46/123 (37%), Positives = 74/123 (60%), Gaps = 10/123 (8%) Query: 173 VIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL--IDSMANSFVGTRSYM 230 +IKG+ YL + KI+HRD+KPSN+LV G IK+ DFGVS + D++ ++ VGT ++M Sbjct: 146 LIKGIEYLHYQ-KIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFM 204 Query: 231 SPERLQGTH--YSVQS-DIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETP 287 +PE L T +S ++ D+W+MG++L G+ P E + +++ A E P Sbjct: 205 APESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPF----MDERIMCLHSKIKSQALEFP 260 Query: 288 PRP 290 +P Sbjct: 261 DQP 263 >4B6L-A nrPDB Length = 281 Score = 78.2 bits (191), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 54/201 (26%), Positives = 94/201 (46%), Gaps = 5/201 (2%) Query: 74 LGAGNGGVVFKVSHKPSGLVMARKLI--HLEIKPAIRNQIIRELQVLHECNSPYIVGFYG 131 LG G ++ + +G A K+I KP R +I+ E+++ + +IV F Sbjct: 17 LGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVRFSH 76 Query: 132 AFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDV 191 F I I +E SL + K + E + ++ GL YL ++ I+HRD+ Sbjct: 77 HFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQR-GILHRDL 135 Query: 192 KPSNILVNSRGEIKLCDFGVSGQLI--DSMANSFVGTRSYMSPERLQGTHYSVQSDIWSM 249 K N + E+K+ DFG++ +L + + GT +Y++PE L + ++D+WS+ Sbjct: 136 KLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPEADVWSL 195 Query: 250 GLSLVEMAVGRYPIPPPDAKE 270 G + + G P D KE Sbjct: 196 GCVMYTLLCGSPPFETADLKE 216 >3QGY-A nrPDB Length = 286 Score = 77.8 bits (190), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 46/152 (30%), Positives = 77/152 (50%), Gaps = 5/152 (3%) Query: 109 NQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLK-KAGRIPEQILG 167 + I E +V+ + + P +V YG I + E M+ G L L+ + G + L Sbjct: 67 DDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLL 126 Query: 168 KVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTR 227 + + V +G+ YL E ++HRD+ N LV IK+ DFG++ ++D S GT+ Sbjct: 127 GMCLDVCEGMAYLEEA-CVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTK 185 Query: 228 ---SYMSPERLQGTHYSVQSDIWSMGLSLVEM 256 + SPE + YS +SD+WS G+ + E+ Sbjct: 186 FPVKWASPEVFSFSRYSSKSDVWSFGVLMWEV 217 >5GNK-A nrPDB Length = 297 Score = 77.8 bits (190), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 61/220 (27%), Positives = 107/220 (48%), Gaps = 14/220 (6%) Query: 63 LKDDDFEKISELGAGNGGVVFKVSHKPSG----LVMARKLIHLEIKPAIRNQIIRELQVL 118 LK+ +F+KI LG+G G V+K P G + +A K + P +I+ E V+ Sbjct: 16 LKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVM 75 Query: 119 HECNSPYIVGFYGAFYSDGEISICMEHMDGGSL-DQVLKKAGRIPEQILGKVSIAVIKGL 177 ++P++ G + + + M+ M G L D V + I Q L + + KG+ Sbjct: 76 ASVDNPHVCRLLGICLTS-TVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGM 134 Query: 178 TYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTR-----SYMSP 232 YL E +++HRD+ N+LV + +K+ DFG++ +L+ + + +M+ Sbjct: 135 NYL-EDRRLVHRDLAARNVLVKTPQHVKITDFGLA-KLLGAEEKEYHAEGGKVPIKWMAL 192 Query: 233 ERLQGTHYSVQSDIWSMGLSLVE-MAVGRYPIPPPDAKEL 271 E + Y+ QSD+WS G+++ E M G P A E+ Sbjct: 193 ESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEI 232 >3MIA-A nrPDB Length = 351 Score = 77.8 bits (190), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 88/332 (26%), Positives = 145/332 (43%), Gaps = 38/332 (11%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEI-KPAIRNQIIRELQVLHECNSPYI 126 +EK++++G G G VFK H+ +G +A K + +E K +RE+++L + Sbjct: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 Query: 127 VGFY------GAFYSDGEISICM-----EHMDGGSLDQVLKKAGRIPEQILGKVSIAVIK 175 V + Y+ + SI + EH G L VL K + +V ++ Sbjct: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK---FTLSEIKRVMQMLLN 135 Query: 176 GLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLI---DSMANSF---VGTRSY 229 GL Y+ ++KI+HRD+K +N+L+ G +KL DFG++ +S N + V T Y Sbjct: 136 GLYYI-HRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWY 194 Query: 230 MSPERLQGTH-YSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAA-ETP 287 PE L G Y D+W G + EM R PI + ++ +L Q+ G E Sbjct: 195 RPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALISQLCGSITPEVW 253 Query: 288 PRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPA 347 P +D+ EL+ + +L + V D ++K L+ +PA Sbjct: 254 P------------NVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPA 301 Query: 348 ERADLKQLMVHAFIKRSDAEEVDFAGWLCSTI 379 +R D + H F SD D G L + + Sbjct: 302 QRIDSDDALNHDFF-WSDPMPSDLKGMLSTHL 332 >6NPU-A nrPDB Length = 298 Score = 77.4 bits (189), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 78/319 (24%), Positives = 132/319 (41%), Gaps = 57/319 (17%) Query: 62 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHEC 121 E++ D +LG G G V++ K L +A K + + + ++E V+ E Sbjct: 22 EMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEV--EEFLKEAAVMKEI 79 Query: 122 NSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR--IPEQILGKVSIAVIKGLTY 179 P +V G + I E M G+L L++ R + +L ++ + + Y Sbjct: 80 KHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEY 139 Query: 180 LREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTR---SYMSPERLQ 236 L EK +HRD+ N LV +K+ DFG+S + + G + + +PE L Sbjct: 140 L-EKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLA 198 Query: 237 GTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRP 296 +S++SD+W+ G+ L E+A Y + P PG Sbjct: 199 YNKFSIKSDVWAFGVLLWEIAT--YGMSP--------------------------YPGID 230 Query: 297 LSSYGMDSRPPMAIFELL--DYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAER---AD 351 LS ++ELL DY + E P P V+ L + C NP++R A+ Sbjct: 231 LSQ----------VYELLEKDYRM-ERPEGCPEKVYEL-----MRACWQWNPSDRPSFAE 274 Query: 352 LKQLMVHAFIKRSDAEEVD 370 + Q F + S ++EV+ Sbjct: 275 IHQAFETMFQESSISDEVE 293 >1ZWS-A nrPDB Length = 288 Score = 77.4 bits (189), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 57/211 (27%), Positives = 102/211 (48%), Gaps = 12/211 (5%) Query: 64 KDDDFEKI-SELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRN-----QIIRELQV 117 K +DF I ELG+G +V K K +GL A K I A R +I RE+ + Sbjct: 9 KVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSI 68 Query: 118 LHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGL 177 L + ++ + + + ++ + +E + GG L L + + E+ ++ G+ Sbjct: 69 LRQVLHHNVITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGV 128 Query: 178 TYLREKHKIMHRDVKPSNILVNSRG----EIKLCDFGVSGQLIDSMA-NSFVGTRSYMSP 232 YL K KI H D+KP NI++ + IKL DFG++ ++ D + + GT +++P Sbjct: 129 NYLHTK-KIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAP 187 Query: 233 ERLQGTHYSVQSDIWSMGLSLVEMAVGRYPI 263 E + +++D+WS+G+ + G P Sbjct: 188 EIVNYEPLGLEADMWSIGVITYILLSGASPF 218 >5X5O-A nrPDB Length = 310 Score = 77.4 bits (189), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 75/272 (27%), Positives = 113/272 (41%), Gaps = 35/272 (12%) Query: 62 ELKDDDFEKISELGAGNGGVVFKVSH-KPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE 120 ++K DD + G G+ G V++ V +KL+ +E +E ++L Sbjct: 11 QIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIE----------KEAEILSV 60 Query: 121 CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKV---SIAVIKGL 177 + I+ FYG I E+ GSL + + R E + + + V KG+ Sbjct: 61 LSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYIN-SNRSEEMDMDHIMTWATDVAKGM 119 Query: 178 TYLREKH--KIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERL 235 YL + K++HRD+K N+++ + G +K+CDFG S + S VGT +M+PE + Sbjct: 120 HYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEVI 179 Query: 236 QGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGR 295 Q S D +S G+ L EM P K LE G QV E R P Sbjct: 180 QSLPVSETCDTYSYGVVLWEMLTREVPF-----KGLE---GLQVAWLVVEKNERLTIP-- 229 Query: 296 PLSSYGMDSRPPMAIFELLDYIVNEPPPKLPS 327 S P + ELL K PS Sbjct: 230 --------SSCPRSFAELLHQCWEADAKKRPS 253 >4MVF-A nrPDB Length = 506 Score = 77.4 bits (189), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 57/196 (29%), Positives = 95/196 (48%), Gaps = 12/196 (6%) Query: 73 ELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRN--QIIRELQVLHECNSPYIVGFY 130 +LG G G V+K K + + A I E K ++N + +E++++ + + P IV Y Sbjct: 64 KLGQGTYGCVYKGIDKVTNQLYA---IKEEKKDRLKNINRFFQEIEIMKKLDHPNIVKLY 120 Query: 131 GAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRD 190 + +D I + ME G L + + G E+ + + + YL + I+HRD Sbjct: 121 ETYENDNYIYLIMELCSGRELFDSIIENGSFTEKNAATIMKQIFSAIFYLHSLN-IVHRD 179 Query: 191 VKPSNILVNSRGE---IKLCDFGVSGQL-IDSMANSFVGTRSYMSPERLQGTHYSVQSDI 246 +KP N L S + +K+ DFG+S L + GT Y++P+ L G Y + DI Sbjct: 180 LKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFTTTKAGTPYYVAPQVLDG-KYDKKCDI 238 Query: 247 WSMGLSLVEMAVGRYP 262 WS G+ + + G YP Sbjct: 239 WSSGVIMYTLLCG-YP 253 >2A27-A nrPDB Length = 321 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 57/211 (27%), Positives = 102/211 (48%), Gaps = 12/211 (5%) Query: 64 KDDDFEKI-SELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRN-----QIIRELQV 117 K +DF I ELG+G +V K K +GL A K I A R +I RE+ + Sbjct: 9 KVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSI 68 Query: 118 LHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGL 177 L + ++ + + + ++ + +E + GG L L + + E+ ++ G+ Sbjct: 69 LRQVLHHNVITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGV 128 Query: 178 TYLREKHKIMHRDVKPSNILVNSRG----EIKLCDFGVSGQLIDSMA-NSFVGTRSYMSP 232 YL K KI H D+KP NI++ + IKL DFG++ ++ D + + GT +++P Sbjct: 129 NYLHTK-KIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAP 187 Query: 233 ERLQGTHYSVQSDIWSMGLSLVEMAVGRYPI 263 E + +++D+WS+G+ + G P Sbjct: 188 EIVNYEPLGLEADMWSIGVITYILLSGASPF 218 >2XYN-A nrPDB Length = 292 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 58/227 (25%), Positives = 100/227 (44%), Gaps = 9/227 (3%) Query: 51 EAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQ 110 E Q E++ D +LG G G V+ K L +A K + + + Sbjct: 17 ENLYFQSMDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEV--EE 74 Query: 111 IIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR--IPEQILGK 168 ++E V+ E P +V G + I E+M G+L L++ R + +L Sbjct: 75 FLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLY 134 Query: 169 VSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTR- 227 ++ + + YL EK +HRD+ N LV +K+ DFG+S + + G + Sbjct: 135 MATQISSAMEYL-EKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKF 193 Query: 228 --SYMSPERLQGTHYSVQSDIWSMGLSLVEMAV-GRYPIPPPDAKEL 271 + +PE L +S++SD+W+ G+ L E+A G P P D ++ Sbjct: 194 PIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQV 240 >4CRS-A nrPDB Length = 341 Score = 76.6 bits (187), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 61/226 (26%), Positives = 109/226 (48%), Gaps = 13/226 (5%) Query: 55 TQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIH---LEIKPAIRNQI 111 + Q+ + DF + L G+ G V +K + + A K + + + + + + Sbjct: 1 SMSQQRFQFNLQDFRCCAVLLRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEV-DSL 59 Query: 112 IRELQVLHECNS---PYIVGFYGAFYSDGEISICMEHMDGGSLD-QVLKKAGRIPEQILG 167 + E ++ NS P++V + F + + ME+ GG L + P + Sbjct: 60 MCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTDVFSEPRAVF- 118 Query: 168 KVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVS--GQLIDSMANSFVG 225 + V+ GL YL E HKI++RD+K N+L+++ G +K+ DFG+ G ++F G Sbjct: 119 -YAACVVLGLQYLHE-HKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCG 176 Query: 226 TRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKEL 271 T +++PE L T Y+ D W +G+ + EM VG P P D +E+ Sbjct: 177 TPEFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEV 222 >4TNB-A nrPDB Length = 590 Score = 76.6 bits (187), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 55/205 (26%), Positives = 98/205 (47%), Gaps = 10/205 (4%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQ----IIRELQVLHEC 121 + F + LG G G V + +G + A K LE K + + + E Q+L + Sbjct: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACK--RLEKKRIKKRKGESMALNEKQILEKV 241 Query: 122 NSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR--IPEQILGKVSIAVIKGLTY 179 NS ++V A+ + + + + M+GG L + G E+ + ++ GL Sbjct: 242 NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLED 301 Query: 180 LREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID-SMANSFVGTRSYMSPERLQGT 238 L ++ + +RD+KP NIL++ G I++ D G++ ++ + + VGT YM+PE L Sbjct: 302 LHHENTV-YRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQ 360 Query: 239 HYSVQSDIWSMGLSLVEMAVGRYPI 263 Y + D W +G + EM G+ P Sbjct: 361 RYGLSPDYWGLGCLIYEMIEGQSPF 385 >5TQX-A nrPDB Length = 655 Score = 76.6 bits (187), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 64/212 (30%), Positives = 96/212 (45%), Gaps = 21/212 (9%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIV 127 +E LG G G V H+ L +A K LE+ R + E+Q++ + N +V Sbjct: 10 WEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCHEIQIMKKLNHANVV 69 Query: 128 GFYGAFYSDGEISI--------CMEHMDGGSLDQVLKK----AGRIPEQILGKVSIAVIK 175 A E++I ME+ GG L ++L K G QIL +S + Sbjct: 70 K---ACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLS-DIGS 125 Query: 176 GLTYLREKHKIMHRDVKPSNILVNSRGEI---KLCDFGVSGQLID-SMANSFVGTRSYMS 231 G+ YL E +KI+HRD+KP NI++ G K+ D G + + + FVGT Y++ Sbjct: 126 GIRYLHE-NKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGELCTEFVGTLQYLA 184 Query: 232 PERLQGTHYSVQSDIWSMGLSLVEMAVGRYPI 263 PE + Y+ D WS G + E G P Sbjct: 185 PELFENKPYTATVDYWSFGTMVFECIAGYRPF 216 >4XEY-B nrPDB Length = 408 Score = 76.6 bits (187), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 78/319 (24%), Positives = 132/319 (41%), Gaps = 57/319 (17%) Query: 62 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHEC 121 E++ D +LG G G V++ K L +A K + + + ++E V+ E Sbjct: 121 EMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEV--EEFLKEAAVMKEI 178 Query: 122 NSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR--IPEQILGKVSIAVIKGLTY 179 P +V G + I E M G+L L++ R + +L ++ + + Y Sbjct: 179 KHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEY 238 Query: 180 LREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTR---SYMSPERLQ 236 L EK +HRD+ N LV +K+ DFG+S + + G + + +PE L Sbjct: 239 L-EKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLA 297 Query: 237 GTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRP 296 +S++SD+W+ G+ L E+A Y + P PG Sbjct: 298 YNKFSIKSDVWAFGVLLWEIAT--YGMSP--------------------------YPGID 329 Query: 297 LSSYGMDSRPPMAIFELL--DYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAER---AD 351 LS ++ELL DY + E P P V+ L + C NP++R A+ Sbjct: 330 LSQ----------VYELLEKDYRM-ERPEGCPEKVYEL-----MRACWQWNPSDRPSFAE 373 Query: 352 LKQLMVHAFIKRSDAEEVD 370 + Q F + S ++EV+ Sbjct: 374 IHQAFETMFQESSISDEVE 392 >2BRG-A nrPDB Length = 297 Score = 76.6 bits (187), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 53/206 (25%), Positives = 96/206 (46%), Gaps = 6/206 (2%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPY 125 +D++ + LG G G V ++ + +A K++ ++ I +E+ + N Sbjct: 7 EDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHEN 66 Query: 126 IVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHK 185 +V FYG + +E+ GG L ++ +PE + ++ G+ YL Sbjct: 67 VVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYL-HGIG 125 Query: 186 IMHRDVKPSNILVNSRGEIKLCDFGVSGQL----IDSMANSFVGTRSYMSPERLQGTHYS 241 I HRD+KP N+L++ R +K+ DFG++ + + N GT Y++PE L+ + Sbjct: 126 ITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFH 185 Query: 242 VQ-SDIWSMGLSLVEMAVGRYPIPPP 266 + D+WS G+ L M G P P Sbjct: 186 AEPVDVWSCGIVLTAMLAGELPWDQP 211 >1CM8-A nrPDB Length = 367 Score = 76.6 bits (187), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 57/201 (28%), Positives = 97/201 (48%), Gaps = 12/201 (5%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAI-RNQIIRELQVLHECNSPYI 126 + + +G+G G V +G +A K ++ + + + REL++L + Sbjct: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 Query: 127 VGFYGAFYSD------GEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL 180 +G F D + + M M G L +++K ++ E + + ++KGL Y+ Sbjct: 87 IGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHE-KLGEDRIQFLVYQMLKGLRYI 144 Query: 181 REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPER-LQGTH 239 I+HRD+KP N+ VN E+K+ DFG++ Q DS +V TR Y +PE L Sbjct: 145 HAA-GIIHRDLKPGNLAVNEDCELKILDFGLARQ-ADSEMTGYVVTRWYRAPEVILNWMR 202 Query: 240 YSVQSDIWSMGLSLVEMAVGR 260 Y+ DIWS+G + EM G+ Sbjct: 203 YTQTVDIWSVGCIMAEMITGK 223 >4FG9-A nrPDB Length = 320 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 66/223 (29%), Positives = 104/223 (46%), Gaps = 10/223 (4%) Query: 67 DFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYI 126 DF + LG G V K + ++A K I E + E+ VLH+ P I Sbjct: 21 DFRDV--LGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMENEIAVLHKIKHPNI 78 Query: 127 VGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKI 186 V + S G + + M+ + GG L + + G E+ ++ V+ + YL + I Sbjct: 79 VALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDL-GI 137 Query: 187 MHRDVKPSNILVNSRGE---IKLCDFGVSGQLID--SMANSFVGTRSYMSPERLQGTHYS 241 +HRD+KP N+L S E I + DFG+S ++ D S+ ++ GT Y++PE L YS Sbjct: 138 VHRDLKPENLLYYSLDEDSKIMISDFGLS-KMEDPGSVLSTACGTPGYVAPEVLAQKPYS 196 Query: 242 VQSDIWSMGLSLVEMAVGRYPI-PPPDAKELELMFGCQVEGDA 283 D WS+G+ + G P DAK E + + E D+ Sbjct: 197 KAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDS 239 >5EFQ-A nrPDB Length = 347 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 79/291 (27%), Positives = 125/291 (42%), Gaps = 40/291 (13%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEI-KPAIRNQIIRELQVLHECNSP 124 D F+ I +G G G V+K K +G ++A K + L+ K IRE+++L + Sbjct: 11 DKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQ 70 Query: 125 YIVGFY----------------GAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGK 168 I+ GAFY + E+MD + + E + Sbjct: 71 SIINMKEIVTDKEDALDFKKDKGAFY------LVFEYMDHDLMGLLESGLVHFNENHIKS 124 Query: 169 VSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSF---VG 225 +++GL Y +K+ +HRD+K SNIL+N+RG+IKL DFG++ + + V Sbjct: 125 FMRQLMEGLDYCHKKN-FLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVI 183 Query: 226 TRSYMSPERLQG-THYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGD-- 282 T Y PE L G Y+ D+WS G L E+ + PI + + +L ++ G Sbjct: 184 TLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKK-PIFQANQELAQLELISRICGSPC 242 Query: 283 AAETPPRPRTPG----RPLSSYGMDSRP-----PMAIFELLDYIVNEPPPK 324 A P + P +P Y R P A +L DY++ P K Sbjct: 243 PAVWPDVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSK 293 >2PL0-A nrPDB Length = 289 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 55/209 (26%), Positives = 102/209 (48%), Gaps = 11/209 (5%) Query: 62 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHEC 121 E+ + + + LGAG G V+ + V + L + P + + E ++ + Sbjct: 19 EVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSP---DAFLAEANLMKQL 75 Query: 122 NSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQI--LGKVSIAVIKGLTY 179 +V Y A + I I E+M+ GSL LK I I L ++ + +G+ + Sbjct: 76 QHQRLVRLY-AVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAF 134 Query: 180 LREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTR---SYMSPERLQ 236 + E++ I HRD++ +NILV+ K+ DFG++ + D+ + G + + +PE + Sbjct: 135 IEERNYI-HRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAIN 193 Query: 237 GTHYSVQSDIWSMGLSLVEMAV-GRYPIP 264 ++++SD+WS G+ L E+ GR P P Sbjct: 194 YGTFTIKSDVWSFGILLTEIVTHGRIPYP 222 >2DQ7-X nrPDB Length = 283 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 60/222 (27%), Positives = 109/222 (49%), Gaps = 15/222 (6%) Query: 58 QKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQV 117 + V E+ + + I LG G G V+ + + V + L + P + E Q+ Sbjct: 1 KDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSP---ESFLEEAQI 57 Query: 118 LHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLK----KAGRIPEQILGKVSIAV 173 + + +V Y A S+ I I E+M+ GSL LK +A ++P L ++ V Sbjct: 58 MKKLKHDKLVQLY-AVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPN--LVDMAAQV 114 Query: 174 IKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTR---SYM 230 G+ Y+ E+ +HRD++ +NILV + K+ DFG++ + D+ + G + + Sbjct: 115 AAGMAYI-ERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWT 173 Query: 231 SPERLQGTHYSVQSDIWSMGLSLVEMAV-GRYPIPPPDAKEL 271 +PE ++++SD+WS G+ L E+ GR P P + +E+ Sbjct: 174 APEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREV 215 >4CSV-A nrPDB Length = 275 Score = 75.9 bits (185), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 53/205 (25%), Positives = 98/205 (47%), Gaps = 9/205 (4%) Query: 73 ELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGA 132 +LG+G G V++ + + +A K L+ + ++E Q++ + P +V YG Sbjct: 18 KLGSGQFGEVYEGKWRNYNIEVAVKT--LKEGTMSVEEFLQEAQIMKKLKHPNLVQLYGV 75 Query: 133 FYSDGEISICMEHMDGGSLDQVLK--KAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRD 190 + I I E+M GSL L+ + + Q L ++ V G+ YL E +HRD Sbjct: 76 CTKEPPIYIITEYMSHGSLLDYLRDCEGHTVNAQALLDMAAQVASGMAYL-ESQNFIHRD 134 Query: 191 VKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTR---SYMSPERLQGTHYSVQSDIW 247 + N LV +K+ DFG++ + + + G + + +PE + +S++SD+W Sbjct: 135 LAARNCLVGENNVVKVADFGLARLINEDEYTARAGAKFPIKWTAPEAISYNRFSIKSDVW 194 Query: 248 SMGLSLVEM-AVGRYPIPPPDAKEL 271 + G+ L E+ G+ P P E+ Sbjct: 195 AFGILLWEIFTYGQVPYPGMSGSEV 219 >5FM2-A nrPDB Length = 355 Score = 75.9 bits (185), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 65/248 (26%), Positives = 111/248 (44%), Gaps = 41/248 (16%) Query: 73 ELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGA 132 E G F + + +A K++ P+ ++ E VL + N P+++ YGA Sbjct: 76 EFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGA 135 Query: 133 FYSDGEISICMEHMDGGSLDQVLKKAGRI------------------PEQ---ILGK-VS 170 DG + + +E+ GSL L+++ ++ P++ +G +S Sbjct: 136 CSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLIS 195 Query: 171 IA--VIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRS 228 A + +G+ YL E K++HRD+ NILV ++K+ DFG+S + + +S+V Sbjct: 196 FAWQISQGMQYLAEM-KLVHRDLAARNILVAEGRKMKISDFGLSRDVYEE--DSYVKRSQ 252 Query: 229 ------YMSPERLQGTHYSVQSDIWSMGLSLVEMAV---GRYPIPPPDAKELELMFGCQV 279 +M+ E L Y+ QSD+WS G+ L E+ YP PP E +F Sbjct: 253 GRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPP-----ERLFNLLK 307 Query: 280 EGDAAETP 287 G E P Sbjct: 308 TGHRMERP 315 >3LZB-A nrPDB Length = 327 Score = 75.9 bits (185), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 60/219 (27%), Positives = 103/219 (47%), Gaps = 12/219 (5%) Query: 63 LKDDDFEKISELGAGNGGVVFKVSHKPSG----LVMARKLIHLEIKPAIRNQIIRELQVL 118 LK+ +F+KI LG+G G V+K P G + +A K + P +I+ E V+ Sbjct: 12 LKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVM 71 Query: 119 HECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLT 178 ++P++ G + I G LD V + I Q L + + KG+ Sbjct: 72 ASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMN 131 Query: 179 YLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTR-----SYMSPE 233 YL E +++HRD+ N+LV + +K+ DFG++ +L+ + + +M+ E Sbjct: 132 YL-EDRRLVHRDLAARNVLVKTPQHVKITDFGLA-KLLGAEEKEYHAEGGKVPIKWMALE 189 Query: 234 RLQGTHYSVQSDIWSMGLSLVE-MAVGRYPIPPPDAKEL 271 + Y+ QSD+WS G+++ E M G P A E+ Sbjct: 190 SILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEI 228 >4RGJ-A nrPDB Length = 520 Score = 75.5 bits (184), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 62/211 (29%), Positives = 106/211 (50%), Gaps = 27/211 (12%) Query: 65 DDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLI---HLEIKPAIRNQIIRELQVLHEC 121 ++ ++ I LG G+ G V K +G A K+I H++ K + ++RE+++L Sbjct: 59 NEQYKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTD-KESLLREVELLKML 117 Query: 122 NSPYIVGFYGAFYSDGEISICMEHMDGGSL-DQVLKK-------AGRIPEQILGKVSIAV 173 + I+ Y F + + + GG L D+++ + A RI +QIL Sbjct: 118 DHINIMKLYEFFEDNNYYYLVSDVYTGGELFDEIISRKRFYEIDAARIIKQILS------ 171 Query: 174 IKGLTYLREKHKIMHRDVKPSNILVNSRGE----IKLCDFGVSGQL-IDSMANSFVGTRS 228 G+TY+ K+ ++HRD+KP NIL+ ++ + IK+ DFG+S +GT Sbjct: 172 --GITYMH-KNNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHFEYSKKMKDKIGTAY 228 Query: 229 YMSPERLQGTHYSVQSDIWSMGLSLVEMAVG 259 Y++P+ L GT Y + DIWS G+ L + G Sbjct: 229 YIAPDVLHGT-YDEKCDIWSCGVILYILLSG 258 >2FO0-A nrPDB Length = 495 Score = 75.1 bits (183), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 77/319 (24%), Positives = 132/319 (41%), Gaps = 57/319 (17%) Query: 62 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHEC 121 E++ D +LG G G V++ K L +A K + + + ++E V+ E Sbjct: 213 EMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEV--EEFLKEAAVMKEI 270 Query: 122 NSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR--IPEQILGKVSIAVIKGLTY 179 P +V G + I E M G+L L++ R + +L ++ + + Y Sbjct: 271 KHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEY 330 Query: 180 LREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTR---SYMSPERLQ 236 L EK +HR++ N LV +K+ DFG+S + + G + + +PE L Sbjct: 331 L-EKKNFIHRNLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLA 389 Query: 237 GTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRP 296 +S++SD+W+ G+ L E+A Y + P PG Sbjct: 390 YNKFSIKSDVWAFGVLLWEIAT--YGMSP--------------------------YPGID 421 Query: 297 LSSYGMDSRPPMAIFELL--DYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAER---AD 351 LS ++ELL DY + E P P V+ L + C NP++R A+ Sbjct: 422 LSQ----------VYELLEKDYRM-ERPEGCPEKVYEL-----MRACWQWNPSDRPSFAE 465 Query: 352 LKQLMVHAFIKRSDAEEVD 370 + Q F + S ++EV+ Sbjct: 466 IHQAFETMFQESSISDEVE 484 >2VN9-A nrPDB Length = 301 Score = 75.1 bits (183), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 82/310 (26%), Positives = 132/310 (42%), Gaps = 63/310 (20%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQII-RELQVLHECNSP 124 D+++ ELG G VV + P+G A K+I+ + A +Q + RE ++ P Sbjct: 4 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 63 Query: 125 YIVGFYGAFYSDGEISICMEHMDGGSL--DQVLKK------AGRIPEQILGKVSIAVIKG 176 IV + + +G + + + GG L D V ++ A +QIL V+ + G Sbjct: 64 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNG 123 Query: 177 LTYLREKHKIMHRDVKPSNILVNSRGE---IKLCDFGVSGQLI-DSMAN-SFVGTRSYMS 231 I+HRD+KP N+L+ S+ + +KL DFG++ ++ D A F GT Y+S Sbjct: 124 ---------IVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLS 174 Query: 232 PERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPR 291 PE L+ Y D+W+ G+ L + VG P D L Q++ A + P Sbjct: 175 PEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQ----QIKAGAYDFP---- 226 Query: 292 TPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERAD 351 S D+ P E +D +NK L NPA+R Sbjct: 227 -------SPEWDTVTP-------------------------EAKDLINKMLTINPAKRIT 254 Query: 352 LKQLMVHAFI 361 + + H +I Sbjct: 255 ASEALKHPWI 264 >3LM0-A nrPDB Length = 327 Score = 74.7 bits (182), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 72/305 (23%), Positives = 134/305 (43%), Gaps = 49/305 (16%) Query: 73 ELGAGNGGVVFKVSHKPSGLVMARKLIHLEIK-PAIRNQIIRELQVLHECNS-PYIVGFY 130 ELG G VV + K +G A K + + R +I+ E+ VL S P ++ + Sbjct: 36 ELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELAKSCPRVINLH 95 Query: 131 GAFYSDGEISICMEHMDGGSLDQVL--KKAGRIPEQILGKVSIAVIKGLTYLREKHKIMH 188 + + EI + +E+ GG + + + A + E + ++ +++G+ YL + + I+H Sbjct: 96 EVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQNN-IVH 154 Query: 189 RDVKPSNILVNS---RGEIKLCDFGVSGQLIDSMA-NSFVGTRSYMSPERLQGTHYSVQS 244 D+KP NIL++S G+IK+ DFG+S ++ + +GT Y++PE L + + Sbjct: 155 LDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACELREIMGTPEYLAPEILNYDPITTAT 214 Query: 245 DIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDS 304 D+W++G+ + P D +E L QV D +E S Sbjct: 215 DMWNIGIIAYMLLTHTSPFVGEDNQETYLNIS-QVNVDYSEET--------------FSS 259 Query: 305 RPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRS 364 +A DF+ L+KNP +R + + H+++++ Sbjct: 260 VSQLA-------------------------TDFIQSLLVKNPEKRPTAEICLSHSWLQQW 294 Query: 365 DAEEV 369 D E + Sbjct: 295 DFENL 299 >3BBT-B nrPDB Length = 328 Score = 74.7 bits (182), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 53/203 (26%), Positives = 102/203 (50%), Gaps = 11/203 (5%) Query: 63 LKDDDFEKISELGAGNGGVVFKVSHKPSG----LVMARKLIHLEIKPAIRNQIIRELQVL 118 LK+ + +++ LG+G G V+K P G + +A K+++ P + + E ++ Sbjct: 12 LKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIM 71 Query: 119 HECNSPYIVGFYGAFYSDGEISICMEHMDGGSL-DQVLKKAGRIPEQILGKVSIAVIKGL 177 + P++V G S I + + M G L + V + I Q+L + + KG+ Sbjct: 72 ASMDHPHLVRLLGVCLSP-TIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGM 130 Query: 178 TYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVS----GQLIDSMANSFVGTRSYMSPE 233 YL E+ +++HRD+ N+LV S +K+ DFG++ G + A+ +M+ E Sbjct: 131 MYLEER-RLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALE 189 Query: 234 RLQGTHYSVQSDIWSMGLSLVEM 256 + ++ QSD+WS G+++ E+ Sbjct: 190 CIHYRKFTHQSDVWSYGVTIWEL 212 >5VD3-A nrPDB Length = 311 Score = 74.3 bits (181), Expect = 8e-14, Method: Compositional matrix adjust. Identities = 66/200 (33%), Positives = 103/200 (51%), Gaps = 11/200 (5%) Query: 65 DDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIK-PAIRNQIIRELQVLHE--C 121 F+++S LG G+ G VFKV K G + A K + P R + + E+ HE Sbjct: 56 QQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGS-HEKVG 114 Query: 122 NSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAG-RIPE-QILGKVSIAVIKGLTY 179 P V A + +G I + G SL Q + G +PE Q+ G + ++ L + Sbjct: 115 QHPCCVRLEQA-WEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLL-ALAH 172 Query: 180 LREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFV-GTRSYMSPERLQGT 238 L + ++H DVKP+NI + RG KL DFG+ +L + A G YM+PE LQG+ Sbjct: 173 LHSQ-GLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGS 231 Query: 239 HYSVQSDIWSMGLSLVEMAV 258 Y +D++S+GL+++E+A Sbjct: 232 -YGTAADVFSLGLTILEVAC 250 >4JG6-A nrPDB Length = 355 Score = 74.3 bits (181), Expect = 9e-14, Method: Compositional matrix adjust. Identities = 64/216 (29%), Positives = 105/216 (48%), Gaps = 19/216 (8%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVL-HECNSP 124 D +E ++G G+ V + HK + + A K+I + E+++L P Sbjct: 35 DGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKS-----KRDPTEEIEILLRYGQHP 89 Query: 125 YIVGFYGAFYSDGE-ISICMEHMDGGSL-DQVLKKAGRIPEQILGKVSIAVIKGLTYLRE 182 I+ Y DG+ + + E M GG L D++L++ E+ V + K + YL Sbjct: 90 NIITLKDV-YDDGKYVYVVTELMKGGELLDKILRQK-FFSEREASAVLFTITKTVEYLHA 147 Query: 183 KHKIMHRDVKPSNIL-VNSRGE---IKLCDFGVSGQLI--DSMANSFVGTRSYMSPERLQ 236 + ++HRD+KPSNIL V+ G I++CDFG + QL + + + T ++++PE L+ Sbjct: 148 Q-GVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLE 206 Query: 237 GTHYSVQSDIWSMGLSLVEMAVGRYPIP--PPDAKE 270 Y DIWS+G+ L M G P P D E Sbjct: 207 RQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPE 242 >6DBN-A nrPDB Length = 316 Score = 73.9 bits (180), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 60/220 (27%), Positives = 105/220 (47%), Gaps = 18/220 (8%) Query: 54 LTQKQKVGELKDDDFEK-----ISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIR 108 +++K+ E+ FEK I +LG G+ G V + P G ++ +KP Sbjct: 18 VSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESG 77 Query: 109 NQII----RELQVLHECNSPYIVGFYGAFYSDGE--ISICMEHMDGGSLDQVL-KKAGRI 161 I +E+++L IV + G DG I + ME + GSL + L K +I Sbjct: 78 GNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKI 137 Query: 162 PEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL-IDSMA 220 + K ++ + KG+ YL + + HRD+ N+LV S ++K+ DFG++ + D Sbjct: 138 NLKQQLKYAVQICKGMDYLGSRQYV-HRDLAARNVLVESEHQVKIGDFGLTKAIETDKEY 196 Query: 221 NSFVGTRS----YMSPERLQGTHYSVQSDIWSMGLSLVEM 256 + R + +PE L + + + SD+WS G++L E+ Sbjct: 197 YTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHEL 236 >5H2U-A nrPDB Length = 267 Score = 73.9 bits (180), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 61/210 (29%), Positives = 100/210 (47%), Gaps = 20/210 (9%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIR------ELQVLH 119 ++F +LG+G G VF+ GL R + + IK R+ ++ E+Q + Sbjct: 6 EEFTLCRKLGSGYFGEVFE------GLWKDR--VQVAIKVISRDNLLHQQMLQSEIQAMK 57 Query: 120 ECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR--IPEQILGKVSIAVIKGL 177 + +I+ Y + I E M GSL ++L+ + +P L ++ V +G+ Sbjct: 58 KLRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGM 117 Query: 178 TYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSY--MSPERL 235 YL E +HRD+ NILV K+ DFG++ + + + S Y +PE L Sbjct: 118 CYL-ESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEAL 176 Query: 236 QGTHYSVQSDIWSMGLSLVEM-AVGRYPIP 264 HYS +SD+WS G+ L EM + G+ P P Sbjct: 177 SRGHYSTKSDVWSFGILLHEMFSRGQVPYP 206 >5Z33-A nrPDB Length = 425 Score = 73.9 bits (180), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 59/213 (27%), Positives = 104/213 (48%), Gaps = 23/213 (10%) Query: 65 DDDFEKISELGAGNGGVVFK-VSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVL-HECN 122 D+ + ELG G G+V V+++ S V +K+ ++ K + + +RE+++L H Sbjct: 30 DERYTVTKELGQGAYGIVCAAVNNQTSEGVAIKKVTNVFSKKILAKRALREIKLLQHFRG 89 Query: 123 SPYIVGFYGAFYSDGEI--------SICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVI 174 I Y D +I + E + L +++ + + ++ Sbjct: 90 HRNITCLY-----DMDIPRPDNFNETYLYEELMECDLAAIIRSGQPLTDAHFQSFIYQIL 144 Query: 175 KGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVS-GQLIDSMANS-----FVGTRS 228 GL Y+ + ++HRD+KP N+LVN+ E+K+CDFG++ G +D N+ +V TR Sbjct: 145 CGLKYIHSAN-VLHRDLKPGNLLVNADCELKICDFGLARGFSVDPEENAGYMTEYVATRW 203 Query: 229 YMSPE-RLQGTHYSVQSDIWSMGLSLVEMAVGR 260 Y +PE L Y+ D+WS+G L E+ GR Sbjct: 204 YRAPEIMLSFQSYTKAIDVWSVGCILAELLGGR 236 >4IAN-A nrPDB Length = 358 Score = 73.9 bits (180), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 48/163 (29%), Positives = 84/163 (51%), Gaps = 12/163 (7%) Query: 112 IRELQVLHECNSP------YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR---IP 162 ++EL+ L + N + + + FY + + E + +L +VLKK G+ + Sbjct: 75 LKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPL-SMNLREVLKKYGKDVGLH 133 Query: 163 EQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVN-SRGEIKLCDFGVSGQLIDSMAN 221 + + S + L L+ + I+H D+KP NILVN S+ +KLCDFG + + D+ Sbjct: 134 IKAVRSYSQQLFLALKLLK-RCNILHADIKPDNILVNESKTILKLCDFGSASHVADNDIT 192 Query: 222 SFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIP 264 ++ +R Y +PE + G Y D+WS+G +L E+ G+ P Sbjct: 193 PYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFP 235 >3Q5I-A nrPDB Length = 504 Score = 73.9 bits (180), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 48/157 (30%), Positives = 78/157 (49%), Gaps = 7/157 (4%) Query: 110 QIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKV 169 +I E+ +L + P I+ + F + E +GG L + + + E + Sbjct: 92 EIYNEISLLKSLDHPNIIKLFDVFEDKKYFYLVTEFYEGGELFEQIINRHKFDECDAANI 151 Query: 170 SIAVIKGLTYLREKHKIMHRDVKPSNILV---NSRGEIKLCDFGVSGQLI-DSMANSFVG 225 ++ G+ YL KH I+HRD+KP NIL+ NS IK+ DFG+S D +G Sbjct: 152 MKQILSGICYLH-KHNIVHRDIKPENILLENKNSLLNIKIVDFGLSSFFSKDYKLRDRLG 210 Query: 226 TRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYP 262 T Y++PE L+ Y+ + D+WS G+ + + G YP Sbjct: 211 TAYYIAPEVLK-KKYNEKCDVWSCGVIMYILLCG-YP 245 >3E7O-A nrPDB Length = 360 Score = 73.9 bits (180), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 80/313 (25%), Positives = 139/313 (44%), Gaps = 36/313 (11%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQI-----IRELQVLHECN 122 ++++ +G+G G+V G+ +A K ++ +NQ REL +L N Sbjct: 24 YQQLKPIGSGAQGIVCAAFDTVLGINVAVK----KLSRPFQNQTHAKRAYRELVLLKCVN 79 Query: 123 SPYIVGFYGAFYSDG------EISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKG 176 I+ F ++ + ME MD +L QV+ + + + + ++ G Sbjct: 80 HKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIHM--ELDHERMSYLLYQMLCG 136 Query: 177 LTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL-IDSMANSFVGTRSYMSPERL 235 + +L I+HRD+KPSNI+V S +K+ DFG++ + M +V TR Y +PE + Sbjct: 137 IKHLHSA-GIIHRDLKPSNIVVKSDCTLKILDFGLARTASTNFMMTPYVVTRYYRAPEVI 195 Query: 236 QGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDA-----KELELMFGCQVEGDAAETPP-R 289 G Y DIWS+G + E+ G D K +E + E AA P R Sbjct: 196 LGMGYKENVDIWSVGCIMGELVKGSVIFQGTDHIDQWNKVIEQLGTPSAEFMAALQPTVR 255 Query: 290 PRTPGRPLSSYGMDSRPPMAIFELL-DYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAE 348 RP + P +A EL D+I P + + + +D ++K L+ +P + Sbjct: 256 NYVENRP-------AYPGIAFEELFPDWIF--PSESERDKIKTSQARDLLSKMLVIDPDK 306 Query: 349 RADLKQLMVHAFI 361 R + + + H +I Sbjct: 307 RISVDEALRHPYI 319 >3OZ6-A nrPDB Length = 388 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 68/241 (28%), Positives = 115/241 (47%), Gaps = 36/241 (14%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQ-IIRELQVLHECN-SPY 125 +E + +LG G G+V+K + +G V+A K I + + Q RE+ +L E + Sbjct: 11 YELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIFDAFQNSTDAQRTFREIMILTELSGHEN 70 Query: 126 IVGFYGAFYSDGE--ISICMEHMDGGSLDQVLKKAGRIPEQILGK-VSIAVIKGLTYLRE 182 IV +D + + + ++M+ L V++ I E + + V +IK + YL Sbjct: 71 IVNLLNVLRADNDRDVYLVFDYMET-DLHAVIR--ANILEPVHKQYVVYQLIKVIKYLHS 127 Query: 183 KHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS-----------------------M 219 ++HRD+KPSNIL+N+ +K+ DFG+S ++ + Sbjct: 128 G-GLLHRDMKPSNILLNAECHVKVADFGLSRSFVNIRRVTNNIPLSINENTENFDDDQPI 186 Query: 220 ANSFVGTRSYMSPERLQG-THYSVQSDIWSMGLSLVEMAVGRYPIPPPDA--KELELMFG 276 +V TR Y +PE L G T Y+ D+WS+G L E+ G+ PI P + +LE + G Sbjct: 187 LTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGK-PIFPGSSTMNQLERIIG 245 Query: 277 C 277 Sbjct: 246 V 246 >2V7O-A nrPDB Length = 336 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 58/212 (27%), Positives = 99/212 (46%), Gaps = 7/212 (3%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQII-RELQVLHECNSP 124 DD++ ELG G VV + K A K+I+ + A +Q + RE ++ P Sbjct: 31 DDYQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 90 Query: 125 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKH 184 IV + + +G + + + GG L + + E +++ + ++ + H Sbjct: 91 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQ-H 149 Query: 185 KIMHRDVKPSNILVNSR---GEIKLCDFGVSGQLIDSMAN--SFVGTRSYMSPERLQGTH 239 I+HRD+KP N+L+ S+ +KL DFG++ ++ F GT Y+SPE L+ Sbjct: 150 DIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDP 209 Query: 240 YSVQSDIWSMGLSLVEMAVGRYPIPPPDAKEL 271 Y DIW+ G+ L + VG P D +L Sbjct: 210 YGKPVDIWACGVILYILLVGYPPFWDEDQHKL 241 >6F3F-A nrPDB Length = 455 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 58/200 (29%), Positives = 99/200 (49%), Gaps = 15/200 (7%) Query: 73 ELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGA 132 +LG G G V+ + + V + L + P ++E QV+ + +V Y A Sbjct: 194 KLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSP---EAFLQEAQVMKKLRHEKLVQLY-A 249 Query: 133 FYSDGEISICMEHMDGGSLDQVLK----KAGRIPEQILGKVSIAVIKGLTYLREKHKIMH 188 S+ I I E+M+ GSL LK K R+P+ L +S + G+ Y+ E+ +H Sbjct: 250 VVSEEPIYIVTEYMNKGSLLDFLKGETGKYLRLPQ--LVDMSAQIASGMAYV-ERMNYVH 306 Query: 189 RDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTR---SYMSPERLQGTHYSVQSD 245 RD++ +NILV K+ DFG++ + D+ + G + + +PE ++++SD Sbjct: 307 RDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSD 366 Query: 246 IWSMGLSLVEMAV-GRYPIP 264 +WS G+ L E+ GR P P Sbjct: 367 VWSFGILLTELTTKGRVPYP 386 >4YZB-A nrPDB Length = 491 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 51/160 (31%), Positives = 85/160 (53%), Gaps = 14/160 (8%) Query: 122 NSPYIVGFYGAFYSDGEISICMEHMDGGSL-DQVLKKAGRIPEQILGKVSIAVIKGLTYL 180 + P I+ Y F G + E GG L D+++ + R E ++ V+ G+TY+ Sbjct: 88 DHPNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISRK-RFSEVDAARIIRQVLSGITYM 146 Query: 181 REKHKIMHRDVKPSNILVNSR---GEIKLCDFGVSGQL--IDSMANSFVGTRSYMSPERL 235 K+KI+HRD+KP N+L+ ++ I++ DFG+S M + +GT Y++PE L Sbjct: 147 H-KNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDK-IGTAYYIAPEVL 204 Query: 236 QGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPD-AKELELM 274 GT Y + D+WS G+ L + G PP + A E +++ Sbjct: 205 HGT-YDEKCDVWSTGVILYILLSG---CPPFNGANEFDIL 240 >4YHJ-A nrPDB Length = 584 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 43/155 (27%), Positives = 78/155 (50%), Gaps = 4/155 (2%) Query: 112 IRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR--IPEQILGKV 169 + E ++L + S ++V A+ + + + + M+GG L + G EQ Sbjct: 233 LNEKRILEKVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFY 292 Query: 170 SIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSM-ANSFVGTRS 228 + + GL L ++ +I++RD+KP NIL++ RG I++ D G++ ++ + VGT Sbjct: 293 AAELCCGLEDL-QRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVG 351 Query: 229 YMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPI 263 YM+PE + Y+ D W +G + EM G P Sbjct: 352 YMAPEVVNNEKYTFSPDWWGLGCLIYEMIQGHSPF 386 >2Y7J-A nrPDB Length = 365 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 59/230 (25%), Positives = 105/230 (45%), Gaps = 19/230 (8%) Query: 74 LGAGNGGVVFKVSHKPSGLVMARKLIHL-------EIKPAIRNQIIRELQVLHE-CNSPY 125 +G G VV + H+ +G A K++ + E +R RE +L + P+ Sbjct: 102 IGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHILRQVAGHPH 161 Query: 126 IVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHK 185 I+ ++ S + + + M G L L + + E+ + ++++ +++L + Sbjct: 162 IITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLEAVSFL-HANN 220 Query: 186 IMHRDVKPSNILVNSRGEIKLCDFGVSGQLI-DSMANSFVGTRSYMSPERLQG----TH- 239 I+HRD+KP NIL++ +I+L DFG S L GT Y++PE L+ TH Sbjct: 221 IVHRDLKPENILLDDNMQIRLSDFGFSCHLEPGEKLRELCGTPGYLAPEILKCSMDETHP 280 Query: 240 -YSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPP 288 Y + D+W+ G+ L + G PP + LM +EG + P Sbjct: 281 GYGKEVDLWACGVILFTLLAGS---PPFWHRRQILMLRMIMEGQYQFSSP 327 >1PHK-A nrPDB Length = 298 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 77/320 (24%), Positives = 133/320 (41%), Gaps = 57/320 (17%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHL--------EIKPAIRNQIIRELQV 117 +++E LG G VV + HKP+ A K+I + E +R ++E+ + Sbjct: 17 ENYEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQELREATLKEVDI 76 Query: 118 LHECNS-PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKG 176 L + + P I+ + ++ + + M G L L + + E+ K+ A+++ Sbjct: 77 LRKVSGHPNIIQLKDTYETNTFFFLVFDLMKKGELFDYLTEKVTLSEKETRKIMRALLEV 136 Query: 177 LTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLI-DSMANSFVGTRSYMSPERL 235 + L K I+HRD+KP NIL++ IKL DFG S QL GT SY++PE + Sbjct: 137 ICALH-KLNIVHRDLKPENILLDDDMNIKLTDFGFSCQLDPGEKLREVCGTPSYLAPEII 195 Query: 236 QGTH------YSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPR 289 + + Y + D+WS G+ + + G PP ++ LM + G+ P Sbjct: 196 ECSMNDNHPGYGKEVDMWSTGVIMYTLLAGS---PPFWHRKQMLMLRMIMSGNYQFGSP- 251 Query: 290 PRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAER 349 E DY S +D V++ L+ P +R Sbjct: 252 ----------------------EWDDY--------------SDTVKDLVSRFLVVQPQKR 275 Query: 350 ADLKQLMVHAFIKRSDAEEV 369 ++ + H F ++ EEV Sbjct: 276 YTAEEALAHPFFQQYVVEEV 295 >5XD6-A nrPDB Length = 305 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 64/220 (29%), Positives = 104/220 (47%), Gaps = 22/220 (10%) Query: 62 ELKD--DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLH 119 EL+D D++ S +G G+ G VF K SG A K + +P + + ++ ++ Sbjct: 16 ELRDITDNYGSKSLIGEGSYGRVFYGILK-SGKAAAIKKLDSSKQP--DQEFLAQVSMVS 72 Query: 120 ECNSPYIVGFYGAFYSDGEISI-CMEHMDGGSLDQVLKK----AGRIPEQILG-----KV 169 +V G + DG + + E+ GSL +L G P +L K+ Sbjct: 73 RLRQENVVALLG-YCVDGPLRVLAYEYAPNGSLHDILHGRKGVKGAQPGPVLSWHQRVKI 131 Query: 170 SIAVIKGLTYLREKHK--IMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA----NSF 223 ++ +GL YL EK ++HRD+K SN+L+ K+ DF +S Q D A Sbjct: 132 AVGAARGLEYLHEKANPHVIHRDIKSSNVLLFDDDVAKIADFDLSNQAPDMAARLHSTRV 191 Query: 224 VGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPI 263 +GT Y +PE S +SD++S G+ L+E+ GR P+ Sbjct: 192 LGTFGYHAPEYAMTGTLSTKSDVYSFGVVLLELLTGRKPV 231 >2JAM-A nrPDB Length = 304 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 62/204 (30%), Positives = 99/204 (48%), Gaps = 13/204 (6%) Query: 74 LGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQII-RELQVLHECNSPYIVGFYGA 132 LG+G VF V + +G + A K I + PA R+ + E+ VL + IV Sbjct: 17 LGSGAFSEVFLVKQRLTGKLFALKCI--KKSPAFRDSSLENEIAVLKKIKHENIVTLEDI 74 Query: 133 FYSDGEISICMEHMDGGSL-DQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDV 191 + S + M+ + GG L D++L++ G E+ V V+ + YL E + I+HRD+ Sbjct: 75 YESTTHYYLVMQLVSGGELFDRILER-GVYTEKDASLVIQQVLSAVKYLHE-NGIVHRDL 132 Query: 192 KPSNILV---NSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWS 248 KP N+L +I + DFG+S + + ++ GT Y++PE L YS D WS Sbjct: 133 KPENLLYLTPEENSKIMITDFGLSKMEQNGIMSTACGTPGYVAPEVLAQKPYSKAVDCWS 192 Query: 249 MGLSLVEMAVGRYPIPPPDAKELE 272 +G+ + G PP +E E Sbjct: 193 IGVITYILLCGY----PPFYEETE 212 >3KN6-A nrPDB Length = 325 Score = 72.8 bits (177), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 54/200 (27%), Positives = 90/200 (45%), Gaps = 11/200 (5%) Query: 74 LGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECN-SPYIVGFYGA 132 LG G+ + K HK S A K+I ++ + +E+ L C P IV + Sbjct: 19 LGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQ----KEITALKLCEGHPNIVKLHEV 74 Query: 133 FYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVK 192 F+ + ME ++GG L + +KK E + ++ ++++ + ++HRD+K Sbjct: 75 FHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDV-GVVHRDLK 133 Query: 193 PSNILV---NSRGEIKLCDFGVSGQL--IDSMANSFVGTRSYMSPERLQGTHYSVQSDIW 247 P N+L N EIK+ DFG + + + T Y +PE L Y D+W Sbjct: 134 PENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYDESCDLW 193 Query: 248 SMGLSLVEMAVGRYPIPPPD 267 S+G+ L M G+ P D Sbjct: 194 SLGVILYTMLSGQVPFQSHD 213 >3A4O-X nrPDB Length = 286 Score = 72.8 bits (177), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 55/211 (26%), Positives = 100/211 (47%), Gaps = 14/211 (6%) Query: 62 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRN--QIIRELQVLH 119 E+ + + + LGAG G V+ + S V + L KP + + E ++ Sbjct: 9 EIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTL-----KPGTMSVQAFLEEANLMK 63 Query: 120 ECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLK--KAGRIPEQILGKVSIAVIKGL 177 +V Y + I I E+M GSL LK + G++ L S + +G+ Sbjct: 64 TLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGM 123 Query: 178 TYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTR---SYMSPER 234 Y+ K+ I HRD++ +N+LV+ K+ DFG++ + D+ + G + + +PE Sbjct: 124 AYIERKNYI-HRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEA 182 Query: 235 LQGTHYSVQSDIWSMGLSLVEMAV-GRYPIP 264 + ++++SD+WS G+ L E+ G+ P P Sbjct: 183 INFGCFTIKSDVWSFGILLYEIVTYGKIPYP 213 >5AWM-A nrPDB Length = 394 Score = 72.4 bits (176), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 72/276 (26%), Positives = 125/276 (45%), Gaps = 33/276 (11%) Query: 113 RELQVLHECNSPYIVGFYGAFYSD------GEISICMEHMDGGSLDQVLKKAGRIPEQIL 166 RE +++ N I+G AF ++ + ME MD +L QV++ + + Sbjct: 92 REFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDA-NLCQVIQMD--LDHDRM 148 Query: 167 GKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS-MANSFVG 225 + ++ G+ +L I+HRD+KPSNI+V + +K+ DFG++ + M +V Sbjct: 149 SYLLYQMLCGIKHLHSA-GIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVV 207 Query: 226 TRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAE 285 TR Y +PE + G Y+ DIWS+G + EM G P D + + +E Sbjct: 208 TRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHID---QWNKIIEQLGTP 264 Query: 286 TPP---------RPRTPGRP-LSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQ 335 +P R RP + Y D P +F + N+ + S + + Sbjct: 265 SPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDN---NQNSRRKAS-----DAR 316 Query: 336 DFVNKCLIKNPAERADLKQLMVHAFIK-RSDAEEVD 370 + ++K L+ +P +R + + + H +I DAEEVD Sbjct: 317 NLLSKMLVIDPEQRISVDEALKHEYINVWYDAEEVD 352 >2XS0-A nrPDB Length = 386 Score = 72.4 bits (176), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 77/308 (25%), Positives = 140/308 (45%), Gaps = 26/308 (8%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQI-----IRELQVLHECN 122 ++ + +G+G G+V ++ R + ++ +NQ REL ++ N Sbjct: 28 YQNLKPIGSGAQGIVCAAYDA----ILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVN 83 Query: 123 SPYIVGFYGAFYSDG------EISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKG 176 I+G F ++ I ME MD +L QV++ + + + + ++ G Sbjct: 84 HKNIIGLLNVFTPQKSLEEFQDVYIVMELMDA-NLCQVIQM--ELDHERMSYLLYQMLCG 140 Query: 177 LTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS-MANSFVGTRSYMSPERL 235 + +L I+HRD+KPSNI+V S +K+ DFG++ S M FV TR Y +PE + Sbjct: 141 IKHLHSA-GIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMVPFVVTRYYRAPEVI 199 Query: 236 QGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGR 295 G Y DIWS+G + EM G P D + + +E P + Sbjct: 200 LGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHID---QWNKVIEQLGTPCPEFMKKLQP 256 Query: 296 PLSSYGMDSRPPMA--IFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLK 353 + +Y +++RP A FE L V P + + + + +D ++K L+ + ++R + Sbjct: 257 TVRTY-VENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVD 315 Query: 354 QLMVHAFI 361 + + H +I Sbjct: 316 EALQHPYI 323 >5FG8-A nrPDB Length = 285 Score = 72.0 bits (175), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 66/236 (27%), Positives = 111/236 (47%), Gaps = 27/236 (11%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQII-RELQVLHECNSP 124 D+++ ELG G +V + K +G A K+I+ + A Q + RE ++ + + P Sbjct: 14 DNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHHP 73 Query: 125 YIVGFYGAFYSDGEISICMEHMDGGSL--DQVLKK------AGRIPEQILGKVSIAVIKG 176 IV + + + + + + GG L D V ++ A +QIL V+ G Sbjct: 74 NIVRLHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQNG 133 Query: 177 LTYLREKHKIMHRDVKPSNILVNSRGE---IKLCDFGVSGQLI-DSMAN-SFVGTRSYMS 231 ++HRD+KP N+L+ S+ + +KL DFG++ ++ D A F GT Y+S Sbjct: 134 ---------VVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLS 184 Query: 232 PERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETP 287 PE L+ Y DIW+ G+ L + VG PP E + Q++ A + P Sbjct: 185 PEVLKKEPYGKSVDIWACGVILYILLVGY----PPFWDEDQHRLYSQIKAGAYDYP 236 >4D2V-A nrPDB Length = 356 Score = 71.6 bits (174), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 52/208 (25%), Positives = 93/208 (44%), Gaps = 5/208 (2%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIV 127 +E +G G V H +G ++A K++ + +I E++ L +I Sbjct: 31 YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNLRHQHIC 90 Query: 128 GFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIM 187 Y + +I + +E+ GG L + R+ E+ V ++ + Y+ + Sbjct: 91 QLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQ-GYA 149 Query: 188 HRDVKPSNILVNSRGEIKLCDFGVSGQ---LIDSMANSFVGTRSYMSPERLQGTHY-SVQ 243 HRD+KP N+L + ++KL DFG+ + D + G +Y +PE +QG Y + Sbjct: 150 HRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQACCGALAYAAPELIQGKSYLGSE 209 Query: 244 SDIWSMGLSLVEMAVGRYPIPPPDAKEL 271 +D+WSMG+ L + G P A L Sbjct: 210 ADVWSMGILLYVLMCGFLPFDDDTAAAL 237 >2H8H-A nrPDB Length = 535 Score = 71.6 bits (174), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 57/200 (28%), Positives = 98/200 (49%), Gaps = 15/200 (7%) Query: 73 ELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGA 132 +LG G G V+ + + V + L + P ++E QV+ + +V Y A Sbjct: 274 KLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSP---EAFLQEAQVMKKLRHEKLVQLY-A 329 Query: 133 FYSDGEISICMEHMDGGSLDQVLK----KAGRIPEQILGKVSIAVIKGLTYLREKHKIMH 188 S+ I I E+M GSL LK K R+P+ L ++ + G+ Y+ E+ +H Sbjct: 330 VVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQ--LVDMAAQIASGMAYV-ERMNYVH 386 Query: 189 RDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTR---SYMSPERLQGTHYSVQSD 245 RD++ +NILV K+ DFG++ + D+ + G + + +PE ++++SD Sbjct: 387 RDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSD 446 Query: 246 IWSMGLSLVEMAV-GRYPIP 264 +WS G+ L E+ GR P P Sbjct: 447 VWSFGILLTELTTKGRVPYP 466 >4LRM-A nrPDB Length = 334 Score = 71.6 bits (174), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 58/213 (27%), Positives = 100/213 (46%), Gaps = 15/213 (7%) Query: 63 LKDDDFEKISELGAGNGGVVFKVSHKPSG----LVMARKLIHLEIKPAIRNQIIRELQVL 118 LK+ +F+KI LG+G G V+K P G + +A K + P +I+ E V+ Sbjct: 16 LKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVM 75 Query: 119 HECNSP---YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIK 175 ++P ++ G + I G LD V + I Q L + + K Sbjct: 76 ASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAK 135 Query: 176 GLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTR-----SYM 230 G+ YL E +++HRD+ N+LV + +K+ DFG++ +L+ + + +M Sbjct: 136 GMNYL-EDRRLVHRDLAARNVLVKTPQHVKITDFGLA-KLLGAEEKEYHAEGGKVPIKWM 193 Query: 231 SPERLQGTHYSVQSDIWSMGLSLVE-MAVGRYP 262 + E + Y+ QSD+WS G+++ E M G P Sbjct: 194 ALESILHRIYTHQSDVWSYGVTVWELMTFGSKP 226 >4O2Z-A nrPDB Length = 377 Score = 71.2 bits (173), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 68/249 (27%), Positives = 114/249 (45%), Gaps = 40/249 (16%) Query: 133 FYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVK 192 ++S ++ + MD ++ VL+ + E + +++GL YL + + HRD+K Sbjct: 120 YHSFEDVYVVTPLMDV-DMNVVLRSRQVLEESHMQYFVYQILRGLKYLHSAN-VAHRDLK 177 Query: 193 PSNILVNSRGEIKLCDFGVSGQLID---SMANSFVGTRSYMSPE-RLQGTHYSVQSDIWS 248 P+N++ N E+K+ DFG+S + +D S +V TR Y PE L+ T+YS DIWS Sbjct: 178 PANLVTNISCELKIIDFGLS-RSVDVPYSELTDYVITRWYRPPELLLENTNYSTAVDIWS 236 Query: 249 MGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPM 308 +G EM R P+ P +L Q G +PP Sbjct: 237 VGCIFAEM-YNRKPVFPGRNTMDQLRMIAQHIG-----------------------KPPA 272 Query: 309 AIFELLDYI--VNEPP------PKLPSGVF-SLEFQDFVNKCLIKNPAERADLKQLMVHA 359 +I E + + +NE P PKL G+ + E DF++K +P++R ++ H Sbjct: 273 SIVEHREALEKLNELPDGSLNIPKLVPGLAGNTEGIDFLSKMWTLDPSKRPTAADMLAHP 332 Query: 360 FIKRSDAEE 368 ++ EE Sbjct: 333 YLAHLHDEE 341 >4NST-A nrPDB Length = 351 Score = 71.2 bits (173), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 61/212 (28%), Positives = 96/212 (45%), Gaps = 28/212 (13%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEI-KPAIRNQIIRELQVLHECNSP 124 D F+ I +G G G V+K K +G ++A K + L+ K IRE+++L + Sbjct: 13 DKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHR 72 Query: 125 YIVGFY----------------GAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGK 168 +V GAFY + E+MD + + E + Sbjct: 73 SVVNMKEIVTDKQDALDFKKDKGAFY------LVFEYMDHDLMGLLESGLVHFSEDHIKS 126 Query: 169 VSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSF---VG 225 +++GL Y +K+ +HRD+K SNIL+N+ G+IKL DFG++ + + V Sbjct: 127 FMKQLMEGLEYCHKKN-FLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVI 185 Query: 226 TRSYMSPERLQG-THYSVQSDIWSMGLSLVEM 256 T Y PE L G Y+ D+WS G L E+ Sbjct: 186 TLWYRPPELLLGEERYTPAIDVWSCGCILGEL 217 >4JLC-A nrPDB Length = 657 Score = 71.2 bits (173), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 69/215 (32%), Positives = 104/215 (48%), Gaps = 29/215 (13%) Query: 74 LGAGNGGVVFKVSHKPSGLVMARKLIH--LEIKPAIRNQIIRELQVLHECNSPYIVGFYG 131 LG G VF+ HK +G + A K+ + ++P + +RE +VL + N IV + Sbjct: 16 LGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPV--DVQMREFEVLKKLNHKNIVKLFA 73 Query: 132 AFYSDGEIS-----ICMEHMDGGSLDQVLKK---AGRIPEQILGKVSIAVIKGLTYLREK 183 + E + + ME GSL VL++ A +PE V V+ G+ +LRE Sbjct: 74 I---EEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE- 129 Query: 184 HKIMHRDVKPSNIL--VNSRGE--IKLCDFGVSGQL-IDSMANSFVGTRSYMSP---ER- 234 + I+HRD+KP NI+ + G+ KL DFG + +L D S GT Y+ P ER Sbjct: 130 NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERA 189 Query: 235 -LQGTH---YSVQSDIWSMGLSLVEMAVGRYPIPP 265 L+ H Y D+WS+G++ A G P P Sbjct: 190 VLRKDHQKKYGATVDLWSVGVTFYHAATGSLPFRP 224 >6CCF-A nrPDB Length = 290 Score = 70.9 bits (172), Expect = 9e-13, Method: Compositional matrix adjust. Identities = 39/96 (40%), Positives = 60/96 (62%), Gaps = 6/96 (6%) Query: 173 VIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL--IDSMANSFVGTRSYM 230 VI GL YL + KI+HRD+KPSN+L+ G +K+ DFGVS Q D+ +S GT ++M Sbjct: 138 VILGLEYLHCQ-KIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFM 196 Query: 231 SPERL--QGTHYSVQS-DIWSMGLSLVEMAVGRYPI 263 +PE + G +S ++ D+W+ G++L G+ P Sbjct: 197 APEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPF 232 >5C26-A nrPDB Length = 299 Score = 70.9 bits (172), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 65/254 (25%), Positives = 124/254 (48%), Gaps = 18/254 (7%) Query: 73 ELGAGNGGVVFKVSHKPSGLVMARKLIHLEIK---PAIRNQIIRELQVLHECNSPYIVGF 129 ELG+GN G V K ++ +V + L+ + PA++++++ E V+ + ++PYIV Sbjct: 34 ELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRM 93 Query: 130 YGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHR 189 G ++ + + ME + G L++ L++ + ++ + ++ V G+ YL E + +HR Sbjct: 94 IGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESN-FVHR 151 Query: 190 DVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTR-----SYMSPERLQGTHYSVQS 244 D+ N+L+ ++ K+ DFG+S L T + +PE + +S +S Sbjct: 152 DLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKS 211 Query: 245 DIWSMGLSLVE-MAVGRYPIPPPDAKELELMFGCQVEGDAAETP---PRPRTPGRPLS-S 299 D+WS G+ + E + G+ P E+ M +G+ P PR L + Sbjct: 212 DVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLE---KGERMGCPAGCPREMYDLMNLCWT 268 Query: 300 YGMDSRPPMAIFEL 313 Y +++RP A EL Sbjct: 269 YDVENRPGFAAVEL 282 >2HW6-A nrPDB Length = 307 Score = 70.9 bits (172), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 52/173 (30%), Positives = 84/173 (48%), Gaps = 20/173 (11%) Query: 108 RNQIIRELQVLHECN-SPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQIL 166 R+++ RE++ L++C + I+ F D + E + GGS+ ++K E+ Sbjct: 54 RSRVFREVETLYQCQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREA 113 Query: 167 GKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEI---KLCDFGV-SGQLIDSMANS 222 +V V L +L K I HRD+KP NIL S ++ K+CDF + SG +++ Sbjct: 114 SRVVRDVAAALDFLHTK-GIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTP 172 Query: 223 FV--------GTRSYMSPERL-----QGTHYSVQSDIWSMGLSLVEMAVGRYP 262 G+ YM+PE + Q T Y + D+WS+G+ L M G YP Sbjct: 173 ITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSG-YP 224 >5SYS-A nrPDB Length = 286 Score = 70.9 bits (172), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 49/162 (30%), Positives = 84/162 (51%), Gaps = 12/162 (7%) Query: 111 IIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLK----KAGRIPEQIL 166 ++E QV+ + +V Y A S+ I I E+M GSL LK K R+P+ L Sbjct: 60 FLQEAQVMKKLRHEKLVQLY-AVVSEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQ--L 116 Query: 167 GKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGT 226 ++ + G+ Y+ E+ +HRD++ +NILV K+ DFG++ + D+ + G Sbjct: 117 VDMAAQIASGMAYV-ERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGA 175 Query: 227 R---SYMSPERLQGTHYSVQSDIWSMGLSLVEMAV-GRYPIP 264 + + +PE ++++SD+WS G+ L E+ GR P P Sbjct: 176 KFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYP 217 >4QTB-A nrPDB Length = 380 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 55/211 (26%), Positives = 101/211 (47%), Gaps = 19/211 (9%) Query: 68 FEKISELGAGNGGVVFKV-SHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYI 126 + ++ +G G G+V H V +K+ E + + + +RE+Q+L + Sbjct: 43 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQ-RTLREIQILLRFRHENV 101 Query: 127 VGFYGAFYSDG-----EISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLR 181 +G + ++ I + M+ L K+ ++ + +++GL Y+ Sbjct: 102 IGIRDILRASTLEAMRDVYIVQDLMETDLYK--LLKSQQLSNDHICYFLYQILRGLKYIH 159 Query: 182 EKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID------SMANSFVGTRSYMSPE-R 234 + ++HRD+KPSN+L+N+ ++K+CDFG++ ++ D +V TR Y +PE Sbjct: 160 SAN-VLHRDLKPSNLLINTTCDLKICDFGLA-RIADPEHDHTGFLTEYVATRWYRAPEIM 217 Query: 235 LQGTHYSVQSDIWSMGLSLVEMAVGRYPIPP 265 L Y+ DIWS+G L EM R PI P Sbjct: 218 LNSKGYTKSIDIWSVGCILAEMLSNR-PIFP 247 >3FXW-A nrPDB Length = 336 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 80/338 (23%), Positives = 132/338 (39%), Gaps = 68/338 (20%) Query: 66 DDFEKISE-LGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSP 124 DD++ + LG G G V + H+ +G A KL++ P R ++ Q P Sbjct: 28 DDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLLY--DSPKARQEVDHHWQA---SGGP 82 Query: 125 YIVGFYGAF----YSDGEISICMEHMDGGSLDQVLKKAG--RIPEQILGKVSIAVIKGLT 178 +IV + + + I ME M+GG L +++ G E+ ++ + + Sbjct: 83 HIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQ 142 Query: 179 YLREKHKIMHRDVKPSNILVNSRGE---IKLCDFGVSGQLIDSMANSFVGTRSYMSPERL 235 +L H I HRDVKP N+L S+ + +KL DFG + + + + T Y++PE L Sbjct: 143 FLH-SHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNALQTPCYTPYYVAPEVL 201 Query: 236 QGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGR 295 Y D+WS+G+ + + G PP G+ Sbjct: 202 GPEKYDKSCDMWSLGVIMYILLCG--------------------------FPPFYSNTGQ 235 Query: 296 PLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQL 355 +S GM R + + P P+ S + + + L +P ER + Q Sbjct: 236 AISP-GMKRRIRLGQYGF-------PNPEWSE--VSEDAKQLIRLLLKTDPTERLTITQF 285 Query: 356 MVHAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV 393 M H +I +S + P TP H A V Sbjct: 286 MNHPWINQS----------------MVVPQTPLHTARV 307 >5JZN-A nrPDB Length = 280 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 54/207 (26%), Positives = 95/207 (45%), Gaps = 16/207 (7%) Query: 49 RLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIR 108 ++ A +T++ KVG +G GN VV + + + A K+I Sbjct: 12 QIPATITERYKVGR----------TIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKE 61 Query: 109 NQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGK 168 + I E+ +L P IV E+ + ME + GG L + + E+ Sbjct: 62 HMIQNEVSILRRVKHPNIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASG 121 Query: 169 VSIAVIKGLTYLREKHKIMHRDVKPSNILV----NSRGEIKLCDFGVSGQLIDSMANSFV 224 + + + YL + I+HRD+KP N+LV + +KL DFG++ ++D + Sbjct: 122 MLYNLASAIKYLHSLN-IVHRDIKPENLLVYEHQDGSKSLKLGDFGLA-TIVDGPLYTVC 179 Query: 225 GTRSYMSPERLQGTHYSVQSDIWSMGL 251 GT +Y++PE + T Y ++ DIW+ G+ Sbjct: 180 GTPTYVAPEIIAETGYGLKVDIWAAGV 206 >4CQG-A nrPDB Length = 331 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 50/208 (24%), Positives = 92/208 (44%), Gaps = 5/208 (2%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIV 127 +E +G G V H +G ++A K++ + ++ E+ L +I Sbjct: 11 YELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGSDLPRVKTEIDALKSLRHQHIC 70 Query: 128 GFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIM 187 Y + +I + +E+ GG L + R+ E+ V ++ + Y+ + Sbjct: 71 QLYHVLETKNKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQILSAVAYVHSQ-GYA 129 Query: 188 HRDVKPSNILVNSRGEIKLCDFGVSGQ---LIDSMANSFVGTRSYMSPERLQGTHY-SVQ 243 HRD+KP N+L + ++KL DFG+ + D G+ +Y +PE +QG Y + Sbjct: 130 HRDLKPENLLFDENHKLKLIDFGLCAKPKGNKDYHLQECCGSLAYAAPELIQGKSYLGSE 189 Query: 244 SDIWSMGLSLVEMAVGRYPIPPPDAKEL 271 +D+WSMG+ L + G P + L Sbjct: 190 ADVWSMGILLYVLMCGFLPFDDDNVMAL 217 >3GC0-A nrPDB Length = 329 Score = 70.1 bits (170), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 57/220 (25%), Positives = 106/220 (48%), Gaps = 15/220 (6%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEI-KPAIRNQIIRELQVLHECNSP 124 D + +I++LG G G V+K + +A K I LE + + IRE+ +L E Sbjct: 34 DRYRRITKLGEGTYGEVYKAIDTVTNETVAIKRIRLEHEEEGVPGTAIREVSLLKELQHR 93 Query: 125 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKH 184 I+ + + + + E+ + L + + K + +++ +I G+ + + Sbjct: 94 NIIELKSVIHHNHRLHLIFEYAE-NDLKKYMDKNPDVSMRVIKSFLYQLINGVNFCHSR- 151 Query: 185 KIMHRDVKPSNILVNSRGE-----IKLCDFGVS---GQLIDSMANSFVGTRSYMSPERLQ 236 + +HRD+KP N+L++ +K+ DFG++ G I + + T Y PE L Sbjct: 152 RCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQFTHEII-TLWYRPPEILL 210 Query: 237 GT-HYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMF 275 G+ HYS DIWS+ EM + + P+ P D+ E++ +F Sbjct: 211 GSRHYSTSVDIWSIACIWAEMLM-KTPLFPGDS-EIDQLF 248 >4FL3-A nrPDB Length = 635 Score = 70.1 bits (170), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 63/251 (25%), Positives = 121/251 (48%), Gaps = 12/251 (4%) Query: 73 ELGAGNGGVVFKVSHKPSGLVMARKLIHLEIK---PAIRNQIIRELQVLHECNSPYIVGF 129 ELG+GN G V K ++ +V + L+ + PA++++++ E V+ + ++PYIV Sbjct: 376 ELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRM 435 Query: 130 YGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHR 189 G ++ + + ME + G L++ L++ + ++ + ++ V G+ YL E + +HR Sbjct: 436 IGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESN-FVHR 493 Query: 190 DVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRS-----YMSPERLQGTHYSVQS 244 D+ N+L+ ++ K+ DFG+S L T + +PE + +S +S Sbjct: 494 DLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKS 553 Query: 245 DIWSMGLSLVE-MAVGRYPIPPPDAKELELMF-GCQVEGDAAETPPRPRTPGRPLSSYGM 302 D+WS G+ + E + G+ P E+ M + G A P +Y + Sbjct: 554 DVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDV 613 Query: 303 DSRPPMAIFEL 313 ++RP A EL Sbjct: 614 ENRPGFAAVEL 624 >4OLI-A nrPDB Length = 645 Score = 70.1 bits (170), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 56/220 (25%), Positives = 106/220 (48%), Gaps = 17/220 (7%) Query: 68 FEKISELGAGNGGVVFKVSHKPS----GLVMARKLIHLEIKPAIRNQIIRELQVLHECNS 123 +KI +LG G+ G V + P+ G ++A K + + P R+ +E+ +L Sbjct: 355 LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYH 414 Query: 124 PYIVGFYGAFYSDGE--ISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLR 181 +I+ + G GE + + ME++ GSL L + Q+L + + +G+ YL Sbjct: 415 EHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLL-LFAQQICEGMAYLH 473 Query: 182 EKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRS-------YMSPER 234 +H I HR++ N+L+++ +K+ DFG++ + + + + R + +PE Sbjct: 474 SQHYI-HRNLAARNVLLDNDRLVKIGDFGLAKAVPE--GHEYYRVREDGDSPVFWYAPEC 530 Query: 235 LQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELM 274 L+ + SD+WS G++L E+ P K LEL+ Sbjct: 531 LKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELI 570 >2WO6-A nrPDB Length = 382 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 65/211 (30%), Positives = 97/211 (45%), Gaps = 13/211 (6%) Query: 59 KVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVL 118 K GE D +E S +G G+ G V K + +A K+I + K A NQ E+++L Sbjct: 47 KNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKII--KNKKAFLNQAQIEVRLL 104 Query: 119 HECNSP------YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR-IPEQILGKVSI 171 N YIV F + + E + D + R + + K + Sbjct: 105 ELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQ 164 Query: 172 AVIKGLTYLRE-KHKIMHRDVKPSNILVNS--RGEIKLCDFGVSGQLIDSMANSFVGTRS 228 + L +L + I+H D+KP NIL+ + R IK+ DFG S QL + ++ +R Sbjct: 165 QMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIY-QYIQSRF 223 Query: 229 YMSPERLQGTHYSVQSDIWSMGLSLVEMAVG 259 Y SPE L G Y + D+WS+G LVEM G Sbjct: 224 YRSPEVLLGMPYDLAIDMWSLGCILVEMHTG 254 >6NT9-A nrPDB Length = 742 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 65/212 (30%), Positives = 101/212 (47%), Gaps = 23/212 (10%) Query: 74 LGAGNGGVVFKVSHKPSGLVMARKLIH--LEIKPAIRNQIIRELQVLHECNSPYIVGFYG 131 LG G VF+ HK +G + A K+ + ++P + +RE +VL + N IV + Sbjct: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPV--DVQMREFEVLKKLNHKNIVKLFA 72 Query: 132 --AFYSDGEISICMEHMDGGSLDQVLKK---AGRIPEQILGKVSIAVIKGLTYLREKHKI 186 + + ME GSL VL++ A +PE V V+ G+ +LRE + I Sbjct: 73 IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE-NGI 131 Query: 187 MHRDVKPSNIL--VNSRGE--IKLCDFGVSGQL-IDSMANSFVGTRSYMSPER-----LQ 236 +HR++KP NI+ + G+ KL DFG + +L D S GT Y+ P+ L+ Sbjct: 132 VHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLR 191 Query: 237 GTH---YSVQSDIWSMGLSLVEMAVGRYPIPP 265 H Y D+WS+G++ A G P P Sbjct: 192 KDHQKKYGATVDLWSIGVTFYHAATGSLPFRP 223 >3DLS-A nrPDB Length = 335 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 55/206 (26%), Positives = 91/206 (44%), Gaps = 11/206 (5%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE-------IKPAIRNQIIRELQVLHE 120 + +S LG+G G V+ K + K I E I+ ++ E+ +L Sbjct: 26 YSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSR 85 Query: 121 CNSPYIVGFYGAFYSDGEISICME-HMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTY 179 I+ F + G + ME H G L + + R+ E + + ++ + Y Sbjct: 86 VEHANIIKVLDIFENQGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASYIFRQLVSAVGY 145 Query: 180 LREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL-IDSMANSFVGTRSYMSPERLQGT 238 LR K I+HRD+K NI++ IKL DFG + L + +F GT Y +PE L G Sbjct: 146 LRLK-DIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGN 204 Query: 239 HY-SVQSDIWSMGLSLVEMAVGRYPI 263 Y + ++WS+G++L + P Sbjct: 205 PYRGPELEMWSLGVTLYTLVFEENPF 230 >4MYG-A nrPDB Length = 372 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 55/197 (27%), Positives = 91/197 (46%), Gaps = 13/197 (6%) Query: 72 SELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAI-RNQIIRELQVLHECNSPYIVGFY 130 + +G+G G V K SG +A K + + I + REL +L ++G Sbjct: 49 THVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLL 108 Query: 131 GAFYSDG------EISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKH 184 F + + M M L +++ E+ + + ++KGL Y+ Sbjct: 109 DVFTPASSLRNFYDFYLVMPFMQT-DLQKIM--GMEFSEEKIQYLVYQMLKGLKYIHSA- 164 Query: 185 KIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPER-LQGTHYSVQ 243 ++HRD+KP N+ VN E+K+ DFG++ D+ +V TR Y +PE L HY+ Sbjct: 165 GVVHRDLKPGNLAVNEDCELKILDFGLARH-ADAEMTGYVVTRWYRAPEVILSWMHYNQT 223 Query: 244 SDIWSMGLSLVEMAVGR 260 DIWS+G + EM G+ Sbjct: 224 VDIWSVGCIMAEMLTGK 240 >2YCR-A nrPDB Length = 323 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 63/213 (29%), Positives = 105/213 (49%), Gaps = 21/213 (9%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIH---------LEIKPAIRNQIIRELQ 116 D++ LG+G G V + + +A K+I E PA+ + E++ Sbjct: 10 DEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPAL--NVETEIE 67 Query: 117 VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKG 176 +L + N P I+ F+ + I +E M+GG L + R+ E ++ Sbjct: 68 ILKKLNHPCIIKIKN-FFDAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLA 126 Query: 177 LTYLREKHKIMHRDVKPSNILVNSRGE---IKLCDFGVSGQLID-SMANSFVGTRSYMSP 232 + YL E + I+HRD+KP N+L++S+ E IK+ DFG S L + S+ + GT +Y++P Sbjct: 127 VQYLHE-NGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAP 185 Query: 233 ERL--QGTH-YSVQSDIWSMGLSLVEMAVGRYP 262 E L GT Y+ D WS+G+ L + + YP Sbjct: 186 EVLVSVGTAGYNRAVDCWSLGVILF-ICLSGYP 217 >4OW8-A nrPDB Length = 283 Score = 69.3 bits (168), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 60/209 (28%), Positives = 95/209 (45%), Gaps = 29/209 (13%) Query: 74 LGAGNGGVVFKVSHKPSGLVMARKLIHLEIK--PAIRNQIIRELQVLHECNSPYIVGF-- 129 + G G V++ G +A K++ E P + E + N P I Sbjct: 19 IATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHPGIASVHD 78 Query: 130 YGAFYSDGE---ISICMEHMDGGSLDQVLKKAGRIP--------EQILGKVSIAVIKGLT 178 YG +GE + ME ++G L+ VLK+ GR+ EQ + IA GL Sbjct: 79 YGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQIAHAAGL- 137 Query: 179 YLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID----SMANSFVGTRSYMSPER 234 +HRDVKP NIL+ G++K+ DFG++ + +D + +GT Y++PE+ Sbjct: 138 --------VHRDVKPGNILITPTGQVKITDFGIA-KAVDAAPVTQTGMVMGTAQYIAPEQ 188 Query: 235 LQGTHYSVQSDIWSMGLSLVEMAVGRYPI 263 G S SD++S+G+ E G+ P Sbjct: 189 ALGHDASPASDVYSLGVVGYEAVSGKRPF 217 >1JNK-A nrPDB Length = 423 Score = 69.3 bits (168), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 74/316 (23%), Positives = 136/316 (43%), Gaps = 42/316 (13%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQI-----IRELQVLHECN 122 ++ + +G+G G+V V+ R + ++ +NQ REL ++ N Sbjct: 64 YQNLKPIGSGAQGIVCAAY----DAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVN 119 Query: 123 SPYIVGFYGAFYSDG------EISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKG 176 I+ F ++ + ME MD +L QV++ + + + + ++ G Sbjct: 120 HKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQM--ELDHERMSYLLYQMLCG 176 Query: 177 LTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS-MANSFVGTRSYMSPERL 235 + +L I+HRD+KPSNI+V S +K+ DFG++ S M +V TR Y +PE + Sbjct: 177 IKHLHSA-GIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVI 235 Query: 236 QGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGR 295 G Y DIWS+G + EM + P D + + +E P + Sbjct: 236 LGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYID---QWNKVIEQLGTPCPEFMKKLQP 292 Query: 296 PLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVF----------SLEFQDFVNKCLIKN 345 + +Y +++RP A P P +F + + +D ++K L+ + Sbjct: 293 TVRNY-VENRPKYAGLTF--------PKLFPDSLFPADSEHNKLKASQARDLLSKMLVID 343 Query: 346 PAERADLKQLMVHAFI 361 PA+R + + H +I Sbjct: 344 PAKRISVDDALQHPYI 359 >3EB0-A nrPDB Length = 383 Score = 69.3 bits (168), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 62/232 (26%), Positives = 109/232 (46%), Gaps = 52/232 (22%) Query: 74 LGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAF 133 LG G+ G+V +V SG A K + + P +N REL ++ + I+ F Sbjct: 15 LGTGSFGIVCEVFDIESGKRFALKKVLQD--PRYKN---RELDIMKVLDHVNIIKLVDYF 69 Query: 134 YSDGE--------------------------------------ISICMEHMDGGSLDQVL 155 Y+ G+ +++ ME++ +L +VL Sbjct: 70 YTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNVIMEYVPD-TLHKVL 128 Query: 156 K---KAGR-IPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSR-GEIKLCDFG 210 K ++GR IP ++ + + + ++ I HRD+KP N+LVNS+ +KLCDFG Sbjct: 129 KSFIRSGRSIPMNLISIYIYQLFRAVGFIHSL-GICHRDIKPQNLLVNSKDNTLKLCDFG 187 Query: 211 VSGQLIDSMAN-SFVGTRSYMSPERLQG-THYSVQSDIWSMGLSLVEMAVGR 260 + +LI S + +++ +R Y +PE + G T Y+ D+WS+G E+ +G+ Sbjct: 188 SAKKLIPSEPSVAYICSRFYRAPELMLGATEYTPSIDLWSIGCVFGELILGK 239 >4EUU-A nrPDB Length = 319 Score = 69.3 bits (168), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 67/224 (29%), Positives = 107/224 (47%), Gaps = 25/224 (11%) Query: 74 LGAGNGGVVFKVSHKPSGLVMARKLIH--LEIKPAIRNQIIRELQVLHECNSPYIVGFYG 131 LG G VF+ HK +G + A K+ + ++P + +RE +VL + N IV + Sbjct: 17 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPV--DVQMREFEVLKKLNHKNIVKLFA 74 Query: 132 --AFYSDGEISICMEHMDGGSLDQVLKK---AGRIPEQILGKVSIAVIKGLTYLREKHKI 186 + + ME GSL VL++ A +PE V V+ G+ +LRE + I Sbjct: 75 IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE-NGI 133 Query: 187 MHRDVKPSNIL--VNSRGE--IKLCDFGVSGQL-IDSMANSFVGTRSYMSPER-----LQ 236 +HR++KP NI+ + G+ KL DFG + +L D S GT Y+ P+ L+ Sbjct: 134 VHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLR 193 Query: 237 GTH---YSVQSDIWSMGLSLVEMAVGRYPIPPPDA--KELELMF 275 H Y D+WS+G++ A G P P + + E+M+ Sbjct: 194 KDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMY 237 >4E20-A nrPDB Length = 290 Score = 69.3 bits (168), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 57/220 (25%), Positives = 105/220 (47%), Gaps = 17/220 (7%) Query: 68 FEKISELGAGNGGVVFKVSHKPS----GLVMARKLIHLEIKPAIRNQIIRELQVLHECNS 123 +KI +LG G+ G V + P+ G ++A K + P +R+ RE+++L Sbjct: 10 LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSGWQREIEILRTLYH 69 Query: 124 PYIVGFYGAFYSDGE--ISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLR 181 +IV + G GE + + ME++ GSL L + Q+L + + +G+ YL Sbjct: 70 EHIVKYKGCCEDQGEKSVQLVMEYVPLGSLRDYLPRHCVGLAQLL-LFAQQICEGMAYLH 128 Query: 182 EKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRS-------YMSPER 234 +H I HR + N+L+++ +K+ DFG++ + + + + R + +PE Sbjct: 129 AQHYI-HRALAARNVLLDNDRLVKIGDFGLAKAVPE--GHEYYRVREDGDSPVFWYAPEC 185 Query: 235 LQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELM 274 L+ + SD+WS G++L E+ P K EL+ Sbjct: 186 LKECKFYYASDVWSFGVTLYELLTYCDSNQSPHTKFTELI 225 >4X3F-A nrPDB Length = 337 Score = 69.3 bits (168), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 52/167 (31%), Positives = 80/167 (47%), Gaps = 27/167 (16%) Query: 114 ELQVLHECNSPYIVGF--YGAFYSDGE---ISICMEHMDGGSLDQVLKKAGRIP------ 162 E + N P I YG +GE + ME ++G L+ VLK+ GR+ Sbjct: 62 EARTTAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALD 121 Query: 163 --EQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID--- 217 EQ + IA GL +HRDVKP NIL+ G++K+ DFG++ + +D Sbjct: 122 MLEQTGRALQIAHAAGL---------VHRDVKPGNILITPTGQVKITDFGIA-KAVDAAP 171 Query: 218 -SMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPI 263 + +GT Y++PE+ G S SD++S+G+ E G+ P Sbjct: 172 VTQTGMVMGTAQYIAPEQALGHDASPASDVYSLGVVGYEAVSGKRPF 218 >5X8I-B nrPDB Length = 346 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 68/240 (28%), Positives = 106/240 (44%), Gaps = 37/240 (15%) Query: 61 GELKDDDFEKISELGAGN-GGVVFKVSHKPSGLVMARKLIHL--EIKPAIRNQIIRELQV 117 G++ +E + LG G G VV + HK G +A K++ A R+ E+QV Sbjct: 8 GDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARS----EIQV 63 Query: 118 LHECNSP------YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQI--LGKV 169 L N+ V F G I I E + G S +K+ G +P ++ + K+ Sbjct: 64 LEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFE-LLGLSTYDFIKENGFLPFRLDHIRKM 122 Query: 170 SIAVIKGLTYLREKHKIMHRDVKPSNILV---------------NSRG----EIKLCDFG 210 + + K + +L K+ H D+KP NIL + R +IK+ DFG Sbjct: 123 AYQICKSVNFLHSN-KLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFG 181 Query: 211 VSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKE 270 S D ++ V TR Y +PE + +S D+WS+G L+E +G P D+KE Sbjct: 182 -SATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKE 240 >1U54-B nrPDB Length = 291 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 52/202 (25%), Positives = 97/202 (48%), Gaps = 11/202 (5%) Query: 65 DDDFEKISELGAGNGGVVFKVSHK-PSG--LVMARKLIHLEI--KPAIRNQIIRELQVLH 119 + D + +LG G+ GVV + PSG + +A K + ++ +P + IRE+ +H Sbjct: 17 EKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMH 76 Query: 120 ECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTY 179 + ++ YG + + G LD++ K G L + ++ V +G+ Y Sbjct: 77 SLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGY 136 Query: 180 LREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTR-----SYMSPER 234 L K + +HRD+ N+L+ +R +K+ DFG+ L + + + ++ +PE Sbjct: 137 LESK-RFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPES 195 Query: 235 LQGTHYSVQSDIWSMGLSLVEM 256 L+ +S SD W G++L EM Sbjct: 196 LKTRTFSHASDTWMFGVTLWEM 217 >4EUT-A nrPDB Length = 396 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 67/224 (29%), Positives = 107/224 (47%), Gaps = 25/224 (11%) Query: 74 LGAGNGGVVFKVSHKPSGLVMARKLIH--LEIKPAIRNQIIRELQVLHECNSPYIVGFYG 131 LG G VF+ HK +G + A K+ + ++P + +RE +VL + N IV + Sbjct: 17 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPV--DVQMREFEVLKKLNHKNIVKLFA 74 Query: 132 AF--YSDGEISICMEHMDGGSLDQVLKK---AGRIPEQILGKVSIAVIKGLTYLREKHKI 186 + + ME GSL VL++ A +PE V V+ G+ +LRE + I Sbjct: 75 IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE-NGI 133 Query: 187 MHRDVKPSNIL--VNSRGE--IKLCDFGVSGQL-IDSMANSFVGTRSYMSPER-----LQ 236 +HR++KP NI+ + G+ KL DFG + +L D S GT Y+ P+ L+ Sbjct: 134 VHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLR 193 Query: 237 GTH---YSVQSDIWSMGLSLVEMAVGRYPIPPPDA--KELELMF 275 H Y D+WS+G++ A G P P + + E+M+ Sbjct: 194 KDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMY 237 >4HZS-A nrPDB Length = 341 Score = 68.9 bits (167), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 52/200 (26%), Positives = 96/200 (48%), Gaps = 11/200 (5%) Query: 67 DFEKISELGAGNGGVVFKVSHK-PSG--LVMARKLIHLEI--KPAIRNQIIRELQVLHEC 121 D + +LG G+ GVV + PSG + +A K + ++ +P + IRE+ +H Sbjct: 13 DLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSL 72 Query: 122 NSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLR 181 + ++ YG + + G LD++ K G L + ++ V +G+ YL Sbjct: 73 DHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYLE 132 Query: 182 EKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTR-----SYMSPERLQ 236 K + +HRD+ N+L+ +R +K+ DFG+ L + + + ++ +PE L+ Sbjct: 133 SK-RFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLK 191 Query: 237 GTHYSVQSDIWSMGLSLVEM 256 +S SD W G++L EM Sbjct: 192 TRTFSHASDTWMFGVTLWEM 211 >3FI2-A nrPDB Length = 353 Score = 68.9 bits (167), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 74/316 (23%), Positives = 136/316 (43%), Gaps = 42/316 (13%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQI-----IRELQVLHECN 122 ++ + +G+G G+V V+ R + ++ +NQ REL ++ N Sbjct: 26 YQNLKPIGSGAQGIVCAAY----DAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVN 81 Query: 123 SPYIVGFYGAFYSDG------EISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKG 176 I+ F ++ + ME MD +L QV++ + + + + ++ G Sbjct: 82 HKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQM--ELDHERMSYLLYQMLCG 138 Query: 177 LTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS-MANSFVGTRSYMSPERL 235 + +L I+HRD+KPSNI+V S +K+ DFG++ S M +V TR Y +PE + Sbjct: 139 IKHLHSA-GIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVI 197 Query: 236 QGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGR 295 G Y DIWS+G + EM + P D + + +E P + Sbjct: 198 LGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYID---QWNKVIEQLGTPCPEFMKKLQP 254 Query: 296 PLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVF----------SLEFQDFVNKCLIKN 345 + +Y +++RP A P P +F + + +D ++K L+ + Sbjct: 255 TVRNY-VENRPKYAGLTF--------PKLFPDSLFPADSEHNKLKASQARDLLSKMLVID 305 Query: 346 PAERADLKQLMVHAFI 361 PA+R + + H +I Sbjct: 306 PAKRISVDDALQHPYI 321 >5NGU-A nrPDB Length = 381 Score = 68.9 bits (167), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 38/100 (38%), Positives = 60/100 (60%), Gaps = 10/100 (10%) Query: 173 VIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID------SMANSFVGT 226 +++GL Y+ + ++HRD+KPSN+L+N+ ++K+CDFG++ ++ D +V T Sbjct: 152 ILRGLKYIHSAN-VLHRDLKPSNLLLNTTCDLKICDFGLA-RVADPDHDHTGFLTEYVAT 209 Query: 227 RSYMSPE-RLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPP 265 R Y +PE L Y+ DIWS+G L EM R PI P Sbjct: 210 RWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNR-PIFP 248 >3I6U-A nrPDB Length = 419 Score = 68.6 bits (166), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 54/168 (32%), Positives = 89/168 (52%), Gaps = 12/168 (7%) Query: 102 EIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRI 161 E PA+ + E+++L + N P I+ F+ + I +E M+GG L + R+ Sbjct: 180 EADPAL--NVETEIEILKKLNHPCIIKIKN-FFDAEDYYIVLELMEGGELFDKVVGNKRL 236 Query: 162 PEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGE---IKLCDFGVSGQLID- 217 E ++ + YL E + I+HRD+KP N+L++S+ E IK+ DFG S L + Sbjct: 237 KEATCKLYFYQMLLAVQYLHE-NGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGET 295 Query: 218 SMANSFVGTRSYMSPERL--QGTH-YSVQSDIWSMGLSLVEMAVGRYP 262 S+ + GT +Y++PE L GT Y+ D WS+G+ L + + YP Sbjct: 296 SLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILF-ICLSGYP 342 >3F3Z-A nrPDB Length = 277 Score = 68.2 bits (165), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 46/169 (27%), Positives = 80/169 (47%), Gaps = 6/169 (3%) Query: 109 NQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGK 168 ++ +E++++ + P I+ Y F + +I + ME GG L + + E + Sbjct: 51 DRFKQEIEIMKSLDHPNIIRLYETFEDNTDIYLVMELCTGGELFERVVHKRVFRESDAAR 110 Query: 169 VSIAVIKGLTYLREKHKIMHRDVKPSNILV---NSRGEIKLCDFGVSGQLI-DSMANSFV 224 + V+ + Y K + HRD+KP N L + +KL DFG++ + M + V Sbjct: 111 IMKDVLSAVAYC-HKLNVAHRDLKPENFLFLTDSPDSPLKLIDFGLAARFKPGKMMRTKV 169 Query: 225 GTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELEL 273 GT Y+SP+ L+G Y + D WS G+ + + G P P E+ L Sbjct: 170 GTPYYVSPQVLEGL-YGPECDEWSAGVMMYVLLCGYPPFSAPTDSEVML 217 >6O8B-A nrPDB Length = 665 Score = 68.2 bits (165), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 66/214 (30%), Positives = 102/214 (47%), Gaps = 27/214 (12%) Query: 74 LGAGNGGVVFKVSHKPSGLVMARKLIH--LEIKPAIRNQIIRELQVLHECNSPYIVGFYG 131 LG G VF+ HK +G + A K+ + ++P + +RE +VL + N IV + Sbjct: 23 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPV--DVQMREFEVLKKLNHKNIVKLFA 80 Query: 132 --AFYSDGEISICMEHMDGGSLDQVLKK---AGRIPEQILGKVSIAVIKGLTYLREKHKI 186 + + ME GSL VL++ A +PE V V+ G+ +LRE + I Sbjct: 81 IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE-NGI 139 Query: 187 MHRDVKPSNIL--VNSRGE--IKLCDFGVSGQLIDSMANSFV---GTRSYMSPER----- 234 +HR++KP NI+ + G+ KL DFG + +L D FV GT Y+ P+ Sbjct: 140 VHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD--EQFVELYGTEEYLHPDMYERAV 197 Query: 235 LQGTH---YSVQSDIWSMGLSLVEMAVGRYPIPP 265 L+ H Y D+WS+G++ A G P P Sbjct: 198 LRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRP 231 >6DBM-A nrPDB Length = 318 Score = 68.2 bits (165), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 57/220 (25%), Positives = 105/220 (47%), Gaps = 17/220 (7%) Query: 68 FEKISELGAGNGGVVFKVSHKPS----GLVMARKLIHLEIKPAIRNQIIRELQVLHECNS 123 +KI +LG G+ G V + P+ G ++A K + + P R+ +E+ +L Sbjct: 33 LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAGPQHRSGWKQEIDILRTLYH 92 Query: 124 PYIVGFYGAFYSDGEISI--CMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLR 181 +I+ + G G S+ ME++ GSL L + Q+L + + +G+ YL Sbjct: 93 EHIIKYKGCCEDAGAASLQLVMEYVPLGSLRDYLPRHSIGLAQLL-LFAQQICEGMAYLH 151 Query: 182 EKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRS-------YMSPER 234 +H I HRD+ N+L+++ +K+ DFG++ + + + + R + +PE Sbjct: 152 SQHYI-HRDLAARNVLLDNDRLVKIGDFGLAKAVPE--GHEYYRVREDGDSPVFWYAPEC 208 Query: 235 LQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELM 274 L+ + SD+WS G++L E+ P K LEL+ Sbjct: 209 LKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELI 248 >6B2Q-A nrPDB Length = 317 Score = 68.2 bits (165), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 52/167 (31%), Positives = 80/167 (47%), Gaps = 27/167 (16%) Query: 114 ELQVLHECNSPYIVGF--YGAFYSDGE---ISICMEHMDGGSLDQVLKKAGRIP------ 162 E + N P I YG +GE + ME ++G L+ VLK+ GR+ Sbjct: 82 EARTTAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALD 141 Query: 163 --EQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID--- 217 EQ + IA GL +HRDVKP NIL+ G++K+ DFG++ + +D Sbjct: 142 MLEQTGRALQIAHAAGL---------VHRDVKPGNILITPTGQVKITDFGIA-KAVDAAP 191 Query: 218 -SMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPI 263 + +GT Y++PE+ G S SD++S+G+ E G+ P Sbjct: 192 VTQTGMVMGTAQYIAPEQALGHDASPASDVYSLGVVGYEAVSGKRPF 238 >4P5Q-A nrPDB Length = 361 Score = 68.2 bits (165), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 50/164 (30%), Positives = 80/164 (48%), Gaps = 12/164 (7%) Query: 108 RNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKK--AGRIPEQI 165 R + E ++ + + P I+ G + I E+M+ GSLD L+K A Q+ Sbjct: 78 RRDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQL 137 Query: 166 LGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVG 225 +G + + G+ YL + + HRD+ NIL+NS K+ DFG+S L D ++ Sbjct: 138 VGMLR-GIASGMKYLSDMGYV-HRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYT- 194 Query: 226 TRS------YMSPERLQGTHYSVQSDIWSMGLSLVE-MAVGRYP 262 TR + SPE + ++ SD+WS G+ L E M+ G P Sbjct: 195 TRGGKIPIRWTSPEAIAYRKFTSASDVWSYGIVLWEVMSYGERP 238 >1ZXE-A nrPDB Length = 303 Score = 68.2 bits (165), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 61/230 (26%), Positives = 104/230 (45%), Gaps = 52/230 (22%) Query: 67 DFEKISELGAGNGGVVFKVSHKPSGLVMA-RKLIHLEIKPAIRNQIIRELQVLHECNSPY 125 DFE+I+ LG G G V K + A +K+ H E K + I+ E+ +L N Y Sbjct: 7 DFEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRHTEEKLS---TILSEVMLLASLNHQY 63 Query: 126 IVGFYGAFY-------------SDGEISICMEHMDGGSL---------DQVLKKAGRIPE 163 +V +Y A+ + I ME+ + +L +Q + R+ Sbjct: 64 VVRYYAAWLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQRDEYWRLFR 123 Query: 164 QILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSM---- 219 QIL + L+Y+ + I+HR++KP NI ++ +K+ DFG++ + S+ Sbjct: 124 QIL--------EALSYIHSQ-GIIHRNLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILK 174 Query: 220 ------------ANSFVGTRSYMSPERLQGT-HYSVQSDIWSMGLSLVEM 256 S +GT Y++ E L GT HY+ + D++S+G+ EM Sbjct: 175 LDSQNLPGSSDNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEM 224 >5MJB-A nrPDB Length = 305 Score = 67.8 bits (164), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 61/212 (28%), Positives = 101/212 (47%), Gaps = 16/212 (7%) Query: 65 DDDFEKISE-LGAGNGGVVFKVSHKPSG---LVMARKLIHLEIKPAIRNQIIRELQVLHE 120 D F KI E +GAG G V+K K G + +A K + R + E ++ + Sbjct: 24 DVSFVKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQ 83 Query: 121 CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKA-GRIPE-QILGKVSIAVIKGLT 178 + I+ G + I E M+ +LD L++ G+ Q++G + + G+ Sbjct: 84 FDHRNIIRLEGVVTKSRPVMIITEFMENCALDSFLRQNDGQFTVIQLVGMLR-GIAAGMK 142 Query: 179 YLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMAN----SFVGTR---SYMS 231 YL E + + HRD+ NILVNS K+ DFG+S L D ++ S +G + + + Sbjct: 143 YLSEMNYV-HRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTA 201 Query: 232 PERLQGTHYSVQSDIWSMGLSLVE-MAVGRYP 262 PE + ++ SD+WS G+ + E M+ G P Sbjct: 202 PEAIAYRKFTSASDVWSYGIVMWEVMSFGERP 233 >2HK5-A nrPDB Length = 270 Score = 67.8 bits (164), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 53/200 (26%), Positives = 98/200 (49%), Gaps = 15/200 (7%) Query: 73 ELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRN--QIIRELQVLHECNSPYIVGFY 130 +LGAG G V+ ++ V + + KP + + E V+ +V + Sbjct: 22 KLGAGQFGEVWMATYNKHTKVAVKTM-----KPGSMSVEAFLAEANVMKTLQHDKLVKLH 76 Query: 131 GAFYSDGEISICMEHMDGGSLDQVLK--KAGRIPEQILGKVSIAVIKGLTYLREKHKIMH 188 A + I I E M GSL LK + + P L S + +G+ ++ +++ I H Sbjct: 77 -AVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYI-H 134 Query: 189 RDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTR---SYMSPERLQGTHYSVQSD 245 RD++ +NILV++ K+ DFG++ + D+ + G + + +PE + ++++SD Sbjct: 135 RDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSD 194 Query: 246 IWSMGLSLVEMAV-GRYPIP 264 +WS G+ L+E+ GR P P Sbjct: 195 VWSFGILLMEIVTYGRIPYP 214 >1JPA-A nrPDB Length = 312 Score = 67.8 bits (164), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 57/202 (28%), Positives = 97/202 (48%), Gaps = 15/202 (7%) Query: 74 LGAGNGGVVFKVSHKPSG---LVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFY 130 +GAG G V K G + +A K + R + E ++ + + P ++ Sbjct: 41 IGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLE 100 Query: 131 GAFYSDGEISICMEHMDGGSLDQVLKKA-GRIPE-QILGKVSIAVIKGLTYLREKHKIMH 188 G + I E M+ GSLD L++ G+ Q++G + + G+ YL + + + H Sbjct: 101 GVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLR-GIAAGMKYLADMNYV-H 158 Query: 189 RDVKPSNILVNSRGEIKLCDFGVSGQLIDSMAN----SFVGTR---SYMSPERLQGTHYS 241 RD+ NILVNS K+ DFG+S L D ++ S +G + + +PE +Q ++ Sbjct: 159 RDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRKFT 218 Query: 242 VQSDIWSMGLSLVE-MAVGRYP 262 SD+WS G+ + E M+ G P Sbjct: 219 SASDVWSYGIVMWEVMSYGERP 240 >5WNL-A nrPDB Length = 342 Score = 67.8 bits (164), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 57/236 (24%), Positives = 112/236 (47%), Gaps = 16/236 (6%) Query: 67 DFEKISELGAGNGGVVFKVSHKPSGLVMARKLI-HLEIKPAIRNQIIRELQVLHECNSPY 125 +F ++G+G G V+KV H +A K L + R +++ E + + Y Sbjct: 21 EFAGWEKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRERMELLEEAKKMEMAKFRY 80 Query: 126 IVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHK 185 I+ YG + + ME+M+ GSL+++L + +P + ++ G+ +L Sbjct: 81 ILPVYGI--CQEPVGLVMEYMETGSLEKLLA-SEPLPWDLRFRIVHETAVGMNFLHCMSP 137 Query: 186 -IMHRDVKPSNILVNSRGEIKLCDFGVS-----GQLIDSMANSFVGTRSYMSPERL--QG 237 ++H ++KP+NIL+++ +K+ DFG++ D + GT +Y+ PER+ + Sbjct: 138 PLLHLNLKPANILLDAHYHVKISDFGLAKCNGMSHSHDLSMDGLFGTIAYLPPERIREKS 197 Query: 238 THYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPP--RPR 291 + + D++S + + + + P D K + + V+G E PP RPR Sbjct: 198 RLFDTKHDVYSFAIVIWGVLTQKKPF--ADEKNILHIMMKVVKGHRPELPPICRPR 251 >3N9X-A nrPDB Length = 432 Score = 67.4 bits (163), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 58/233 (24%), Positives = 100/233 (42%), Gaps = 43/233 (18%) Query: 74 LGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIR-NQIIRELQVLHECNSPYIVGFYGA 132 +G G+ G V+ K + +A K ++ + I +I+RE+ +L+ S YI+ Y Sbjct: 34 IGRGSYGYVYLAYDKNTEKNVAIKKVNRMFEDLIDCKRILREITILNRLKSDYIIRLYDL 93 Query: 133 FYSDG-----EISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIM 187 D E+ I +E D L ++ K + E+ + + ++ G ++ E I+ Sbjct: 94 IIPDDLLKFDELYIVLEIADS-DLKKLFKTPIFLTEEHIKTILYNLLLGENFIHES-GII 151 Query: 188 HRDVKPSNILVNSRGEIKLCDFGVSGQL------------------------IDSMANSF 223 HRD+KP+N L+N +K+CDFG++ + + S Sbjct: 152 HRDLKPANCLLNQDCSVKVCDFGLARTINSEKDTNIVNDLEENEEPGPHNKNLKKQLTSH 211 Query: 224 VGTRSYMSPER-LQGTHYSVQSDIWSMGLSLVEMA----------VGRYPIPP 265 V TR Y +PE L +Y+ DIWS G E+ R+P+ P Sbjct: 212 VVTRWYRAPELILLQENYTKSIDIWSTGCIFAELLNMLQSHINDPTNRFPLFP 264 >1K9A-A nrPDB Length = 450 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 47/163 (28%), Positives = 80/163 (49%), Gaps = 6/163 (3%) Query: 106 AIRNQIIRELQVLHECNSPYIVGFYGAFYSD-GEISICMEHMDGGSLDQVLKKAGR--IP 162 A + E V+ + +V G + G + I E+M GSL L+ GR + Sbjct: 228 ATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLG 287 Query: 163 EQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANS 222 L K S+ V + + YL E + +HRD+ N+LV+ K+ DFG++ + + Sbjct: 288 GDCLLKFSLDVCEAMEYL-EGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG 346 Query: 223 FVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEM-AVGRYPIP 264 + + + +PE L+ +S +SD+WS G+ L E+ + GR P P Sbjct: 347 KLPVK-WTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYP 388 >2JC6-A nrPDB Length = 334 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 63/222 (28%), Positives = 98/222 (44%), Gaps = 8/222 (3%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIV 127 FE LG G V K +G + A K I + + I E+ VL + IV Sbjct: 24 FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIV 83 Query: 128 GFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIM 187 + S + + M+ + GG L + + G E+ + V+ + YL + I+ Sbjct: 84 ALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLH-RMGIV 142 Query: 188 HRDVKPSNILVNSRGE---IKLCDFGVSGQ--LIDSMANSFVGTRSYMSPERLQGTHYSV 242 HRD+KP N+L S+ E I + DFG+S D M+ + GT Y++PE L YS Sbjct: 143 HRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTA-CGTPGYVAPEVLAQKPYSK 201 Query: 243 QSDIWSMGLSLVEMAVGRYPI-PPPDAKELELMFGCQVEGDA 283 D WS+G+ + G P D+K E + + E D+ Sbjct: 202 AVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDS 243 >4LQP-A nrPDB Length = 508 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 46/152 (30%), Positives = 77/152 (50%), Gaps = 9/152 (5%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIR---ELQVLHECN 122 +DF + +G G G V V K +G + A K + L+ + ++Q+ E VL + Sbjct: 102 EDFHTVKVIGKGAFGEVRLVQKKDTGKIYAMKTL-LKSEMYKKDQLAHVKAERDVLAGSD 160 Query: 123 SPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLRE 182 SP++V Y +F + + ME + GG L +L + E + + + + + Sbjct: 161 SPWVVSLYYSFQDAQYLYLIMEFLPGGDLMTMLIRWQLFTEDV---TRFYMAECILAIET 217 Query: 183 KHKI--MHRDVKPSNILVNSRGEIKLCDFGVS 212 HK+ +HR +KP NIL++ RG IKL DFG+S Sbjct: 218 IHKLGFIHRAIKPDNILIDIRGHIKLSDFGLS 249 Score = 33.5 bits (75), Expect = 0.17, Method: Compositional matrix adjust. Identities = 17/45 (37%), Positives = 23/45 (51%) Query: 219 MANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPI 263 MA S VGT Y++PE Y + D WS+G + E +G P Sbjct: 319 MAYSTVGTPDYIAPEIFLYQGYGQECDWWSLGAIMYECLIGWPPF 363 >1BYG-A nrPDB Length = 278 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 47/163 (28%), Positives = 80/163 (49%), Gaps = 6/163 (3%) Query: 106 AIRNQIIRELQVLHECNSPYIVGFYGAFYSD-GEISICMEHMDGGSLDQVLKKAGR--IP 162 A + E V+ + +V G + G + I E+M GSL L+ GR + Sbjct: 56 ATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLG 115 Query: 163 EQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANS 222 L K S+ V + + YL E + +HRD+ N+LV+ K+ DFG++ + + Sbjct: 116 GDCLLKFSLDVCEAMEYL-EGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG 174 Query: 223 FVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEM-AVGRYPIP 264 + + + +PE L+ +S +SD+WS G+ L E+ + GR P P Sbjct: 175 KLPVK-WTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYP 216 >1LUF-A nrPDB Length = 343 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 56/229 (24%), Positives = 100/229 (43%), Gaps = 36/229 (15%) Query: 62 ELKDDDFEKISELGAGNGGVVFK------VSHKPSGLVMARKLIHLEIKPAIRNQIIREL 115 E ++ E + ++G G G VF+ + ++P +V A K++ E ++ RE Sbjct: 43 EYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMV-AVKMLKEEASADMQADFQREA 101 Query: 116 QVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKA----------------- 158 ++ E ++P IV G + + E+M G L++ L+ Sbjct: 102 ALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRA 161 Query: 159 -----GRIPEQILGKVSIA--VIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGV 211 G P ++ IA V G+ YL E+ K +HRD+ N LV +K+ DFG+ Sbjct: 162 RVSSPGPPPLSCAEQLCIARQVAAGMAYLSER-KFVHRDLATRNCLVGENMVVKIADFGL 220 Query: 212 SGQLIDSMANSFVGTRS----YMSPERLQGTHYSVQSDIWSMGLSLVEM 256 S + + G + +M PE + Y+ +SD+W+ G+ L E+ Sbjct: 221 SRNIYSADYYKADGNDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEI 269 >6GQK-A nrPDB Length = 328 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 62/230 (26%), Positives = 105/230 (45%), Gaps = 30/230 (13%) Query: 74 LGAGNGGVVFKVSHK-----PSGLVMARKLIHLEIKPAIRNQIIRELQVL-HECNSPYIV 127 LGAG G V + + + + + +A K++ R ++ EL+VL + N IV Sbjct: 49 LGAGAFGKVVEATAQGLIKSDAAMTVAVKMLKPSAHSTEREALMSELKVLSYLGNHENIV 108 Query: 128 GFYGAFYSDGEISICMEHMDGGSLDQVL--KKAGRIPEQI--------------LGKVSI 171 GA G + E+ G L L K+ +P ++ L S Sbjct: 109 NLLGACTHGGPTLVITEYCCYGDLLNFLRRKRDEFVPYKVAPEDLYKDFLTLEHLLSFSY 168 Query: 172 AVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTR---- 227 V KG+ +L K+ I HRD+ NIL+ K+CDFG++ + + G Sbjct: 169 QVAKGMAFLASKNCI-HRDLAARNILLTHGNITKICDFGLARDIKNDSNYVDKGNARLPV 227 Query: 228 SYMSPERLQGTHYSVQSDIWSMGLSLVEM-AVGRYPIP--PPDAKELELM 274 +M+PE + + Y+ +SD+WS G+ L E+ ++G P P P D+K +++ Sbjct: 228 KWMAPESIFNSVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMI 277 >3LMG-A nrPDB Length = 344 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 52/206 (25%), Positives = 100/206 (48%), Gaps = 17/206 (8%) Query: 63 LKDDDFEKISELGAGNGGVVFKVSHKPSG----LVMARKLIHLEIKPAIRNQIIRELQVL 118 K+ + K+ LG+G G V K P G + + K+I + + + + Sbjct: 28 FKETELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAI 87 Query: 119 HECNSPYIVGFYGAFYSDGEISICMEHMDGGSL-DQVLKKAGRIPEQILGKVSIAVIKGL 177 + +IV G + + +++ GSL D V + G + Q+L + + KG+ Sbjct: 88 GSLDHAHIVRLLG-LCPGSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGM 146 Query: 178 TYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSG-------QLIDSMANSFVGTRSYM 230 YL E+H ++HR++ N+L+ S ++++ DFGV+ QL+ S A + + +M Sbjct: 147 YYL-EEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPI---KWM 202 Query: 231 SPERLQGTHYSVQSDIWSMGLSLVEM 256 + E + Y+ QSD+WS G+++ E+ Sbjct: 203 ALESIHFGKYTHQSDVWSYGVTVWEL 228 >3DKO-A nrPDB Length = 318 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 56/200 (28%), Positives = 94/200 (47%), Gaps = 13/200 (6%) Query: 74 LGAGNGGVVFKVSHKPSG---LVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFY 130 +GAG G V K G + +A K + + R + E ++ + + P +V Sbjct: 51 IGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHPNVVHLE 110 Query: 131 GAFYSDGEISICMEHMDGGSLDQVLKKA-GRIPE-QILGKVSIAVIKGLTYLREKHKIMH 188 G + I +E M+ G+LD L+K G+ Q++G + + G+ YL + + H Sbjct: 111 GVVTRGKPVMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLR-GIAAGMRYLADMGYV-H 168 Query: 189 RDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRS-----YMSPERLQGTHYSVQ 243 RD+ NILVNS K+ DFG+S + D + T + +PE +Q ++ Sbjct: 169 RDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRKFTSA 228 Query: 244 SDIWSMGLSLVE-MAVGRYP 262 SD+WS G+ + E M+ G P Sbjct: 229 SDVWSYGIVMWEVMSYGERP 248 >6FYV-A nrPDB Length = 337 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 64/231 (27%), Positives = 101/231 (43%), Gaps = 33/231 (14%) Query: 68 FEKISELGAGN-GGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSP-- 124 +E + LG G G VV + H G+ +A K++ + R E+QVL NS Sbjct: 16 YEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIV--KNVGRYREAARSEIQVLEHLNSTDP 73 Query: 125 ----YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQI--LGKVSIAVIKGLT 178 V F G + I E + G S +K+ +P QI + +++ + + + Sbjct: 74 NSVFRCVQMLEWFDHHGHVCIVFE-LLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSIN 132 Query: 179 YLREKHKIMHRDVKPSNILV---------NSR----------GEIKLCDFGVSGQLIDSM 219 +L K+ H D+KP NIL NS+ +IK+ DFG S D Sbjct: 133 FLHHN-KLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFG-SATYDDEH 190 Query: 220 ANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKE 270 ++ V TR Y +PE + +S D+WS+G L+E +G D+KE Sbjct: 191 HSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKE 241 >5TUR-A nrPDB Length = 404 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 36/91 (39%), Positives = 53/91 (58%), Gaps = 4/91 (4%) Query: 177 LTYLREKHK--IMHRDVKPSNILVN-SRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPE 233 L +R H ++HRD+K NIL++ +RGE+KL DFG L D++ F GTR Y PE Sbjct: 243 LEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPE 302 Query: 234 RLQGTHYSVQS-DIWSMGLSLVEMAVGRYPI 263 ++ Y +S +WS+G+ L +M G P Sbjct: 303 WIRYHRYHGRSAAVWSLGILLYDMVCGDIPF 333 >2R2P-A nrPDB Length = 295 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 56/195 (28%), Positives = 92/195 (47%), Gaps = 14/195 (7%) Query: 74 LGAGNGGVVFKVSHKPSG---LVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFY 130 +GAG G V K G L +A K + + R + E ++ + + P I+ Sbjct: 30 IGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIHLE 89 Query: 131 GAFYSDGEISICMEHMDGGSLDQVLKKA-GRIPE-QILGKVSIAVIKGLTYLREKHKIMH 188 G + I E+M+ GSLD LKK G+ Q++G + + G+ YL + + H Sbjct: 90 GVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLR-GISAGMKYLSDMGYV-H 147 Query: 189 RDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRS------YMSPERLQGTHYSV 242 RD+ NIL+NS K+ DFG+S L D ++ TR + +PE + ++ Sbjct: 148 RDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYT-TRGGKIPIRWTAPEAIAFRKFTS 206 Query: 243 QSDIWSMGLSLVEMA 257 SD+WS G+ + E+ Sbjct: 207 ASDVWSYGIVMWEVV 221 >2Y6O-A nrPDB Length = 291 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 50/164 (30%), Positives = 81/164 (49%), Gaps = 12/164 (7%) Query: 108 RNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKA-GRIPE-QI 165 R + E ++ + + P I+ G + I E+M+ GSLD L+K GR Q+ Sbjct: 59 RRDFLSEASIMGQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQL 118 Query: 166 LGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVG 225 +G + + G+ YL + + HRD+ NILVNS K+ DFG+S L D ++ Sbjct: 119 VGMLR-GIGSGMKYLSDMSYV-HRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYT- 175 Query: 226 TRS------YMSPERLQGTHYSVQSDIWSMGLSLVE-MAVGRYP 262 TR + +PE + ++ SD+WS G+ + E M+ G P Sbjct: 176 TRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERP 219 >5ZTN-A nrPDB Length = 429 Score = 66.2 bits (160), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 79/323 (24%), Positives = 139/323 (43%), Gaps = 34/323 (10%) Query: 68 FEKISELGAGNGGVVFKVS----HKPSGLVMAR--KLIHLEIKPAIRNQIIRELQVLHEC 121 +E + +G G+ G V K H+ L M R K H + IR I+ L+ + Sbjct: 99 YEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIR--ILEHLRKQDKD 156 Query: 122 NSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLK-KAGRIPEQILGKVSIAVIKGLTYL 180 N+ ++ F I + E + + + K K ++ K + ++++ L L Sbjct: 157 NTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDAL 216 Query: 181 REKHKIMHRDVKPSNILVNSRGE--IKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGT 238 K++I+H D+KP NIL+ +G IK+ DFG S +++ +R Y +PE + G Sbjct: 217 -HKNRIIHCDLKPENILLKQQGRSGIKVIDFG-SSCYEHQRVYTYIQSRFYRAPEVILGA 274 Query: 239 HYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRP-- 296 Y + D+WS+G L E+ G YP+ P + + +L C +E + R Sbjct: 275 RYGMPIDMWSLGCILAELLTG-YPLLPGEDEGDQL--ACMIELLGMPSQKLLDASKRAKN 331 Query: 297 -LSSYGMDSRPPMAIFELLDYIVN---------EPPPKLPSGVFSLE------FQDFVNK 340 +SS G + ++N PP+ +L+ F DF+ + Sbjct: 332 FVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQ 391 Query: 341 CLIKNPAERADLKQLMVHAFIKR 363 CL +PA R Q + H +++R Sbjct: 392 CLEWDPAVRMTPGQALRHPWLRR 414 >3BGP-A nrPDB Length = 333 Score = 66.2 bits (160), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 36/91 (39%), Positives = 53/91 (58%), Gaps = 4/91 (4%) Query: 177 LTYLREKHK--IMHRDVKPSNILVN-SRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPE 233 L +R H ++HRD+K NIL++ +RGE+KL DFG L D++ F GTR Y PE Sbjct: 172 LEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPE 231 Query: 234 RLQGTHYSVQS-DIWSMGLSLVEMAVGRYPI 263 ++ Y +S +WS+G+ L +M G P Sbjct: 232 WIRYHRYHGRSAAVWSLGILLYDMVCGDIPF 262 >5AR8-A nrPDB Length = 326 Score = 66.2 bits (160), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 55/210 (26%), Positives = 99/210 (47%), Gaps = 24/210 (11%) Query: 74 LGAGNGGVVFKVSHKPSGLVMARKLIHLE--IKPAIRNQIIRELQVLHECNSPYIVGFYG 131 L G G V H + +A K +H+ + + R ++RE ++LH+ YI+ G Sbjct: 40 LSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILG 99 Query: 132 AFYSDGEISICMEHMDGGSLDQVLKKAGRIPE-------QILGKVSIAVIKGLTYLREKH 184 + I E+M GSL+++L + P+ +IL ++++ G+ YL Sbjct: 100 ICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIAL----GVNYLHNMT 155 Query: 185 -KIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFV-------GTRSYMSPERL- 235 ++H D+K NIL+++ +K+ DFG+S + S++ S GT YM PE Sbjct: 156 PPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYE 215 Query: 236 --QGTHYSVQSDIWSMGLSLVEMAVGRYPI 263 Q + S++ DI+S + E+ + P Sbjct: 216 PGQKSRASIKHDIYSYAVITWEVLSRKQPF 245 >3V5Q-A nrPDB Length = 297 Score = 65.9 bits (159), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 67/255 (26%), Positives = 109/255 (42%), Gaps = 33/255 (12%) Query: 60 VGELKDDDFEKISELGAGNGGVVF-----KVSHKPSGLVMARKLIHLEIKPAIRNQIIRE 114 V +K D ELG G G VF +S +++A K + + A R RE Sbjct: 9 VQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALK-DPTLAARKDFQRE 67 Query: 115 LQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAG--------RIPEQIL 166 ++L +IV FYG + + E+M G L++ L+ G P Q Sbjct: 68 AELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAK 127 Query: 167 GKVSIA--------VIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS 218 G++ ++ + G+ YL +H +HRD+ N LV + +K+ DFG+S + S Sbjct: 128 GELGLSQMLHIASQIASGMVYLASQH-FVHRDLATRNCLVGANLLVKIGDFGMSRD-VYS 185 Query: 219 MANSFVGTRS-----YMSPERLQGTHYSVQSDIWSMGLSLVEM-AVGRYPIPPPDAKELE 272 VG + +M PE + ++ +SD+WS G+ L E+ G+ P E+ Sbjct: 186 TDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEV- 244 Query: 273 LMFGCQVEGDAAETP 287 C +G E P Sbjct: 245 --IECITQGRVLERP 257 >4M69-B nrPDB Length = 283 Score = 65.9 bits (159), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 47/170 (27%), Positives = 86/170 (50%), Gaps = 13/170 (7%) Query: 114 ELQVLHECNSPYIVGFYGAFYSDG----EISICMEHMDGGSLDQVLKKAGRIPEQILGKV 169 E++ + + +SP I+ +G E SI ME+ + G+L ++L + + + + Sbjct: 58 EIKTMKKFDSPNILRIFGICIDQTVKPPEFSIVMEYCELGTLRELLDREKDLTMSVRSLL 117 Query: 170 SIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSG--QLIDSMANSFVGTR 227 + +GL Y + +HR++ S+ LV ++KL F +S I A S R Sbjct: 118 VLRAARGL-YRLHHSETLHRNISSSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAER 176 Query: 228 S----YMSPERLQGTH--YSVQSDIWSMGLSLVEMAVGRYPIPPPDAKEL 271 S Y+SPERL+ Y ++++I+S G+ L E+A G+ P D+K++ Sbjct: 177 SSSTIYVSPERLKNPFCLYDIKAEIYSFGIVLWEIATGKIPFEGCDSKKI 226 >4RC3-A nrPDB Length = 289 Score = 65.9 bits (159), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 36/91 (39%), Positives = 53/91 (58%), Gaps = 4/91 (4%) Query: 177 LTYLREKHK--IMHRDVKPSNILVN-SRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPE 233 L +R H ++HRD+K NIL++ +RGE+KL DFG L D++ F GTR Y PE Sbjct: 128 LEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPE 187 Query: 234 RLQGTHYSVQS-DIWSMGLSLVEMAVGRYPI 263 ++ Y +S +WS+G+ L +M G P Sbjct: 188 WIRYHRYHGRSAAVWSLGILLYDMVCGDIPF 218 >4BTF-A nrPDB Length = 469 Score = 65.9 bits (159), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 47/170 (27%), Positives = 86/170 (50%), Gaps = 13/170 (7%) Query: 114 ELQVLHECNSPYIVGFYGAFYSDG----EISICMEHMDGGSLDQVLKKAGRIPEQILGKV 169 E++ + + +SP I+ +G E SI ME+ + G+L ++L + + + + Sbjct: 244 EIKTMKKFDSPNILRIFGICIDQTVKPPEFSIVMEYCELGTLRELLDREKDLTMSVRSLL 303 Query: 170 SIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSG--QLIDSMANSFVGTR 227 + +GL Y + +HR++ S+ LV ++KL F +S I A S R Sbjct: 304 VLRAARGL-YRLHHSETLHRNISSSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAER 362 Query: 228 S----YMSPERLQG--THYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKEL 271 S Y+SPERL+ Y ++++I+S G+ L E+A G+ P D+K++ Sbjct: 363 SSSTIYVSPERLKNPFCLYDIKAEIYSFGIVLWEIATGKIPFEGCDSKKI 412 >5E8V-A nrPDB Length = 316 Score = 65.5 bits (158), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 63/216 (29%), Positives = 97/216 (44%), Gaps = 32/216 (14%) Query: 149 GSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHK--------IMHRDVKPSNILVNS 200 G+L + L + I + L K+ ++ +G+ +L H I+HRD+K SNILV + Sbjct: 98 GNLQEYLTR-HVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKN 156 Query: 201 RGEIKLCDFGVSGQL-----IDSMANS-FVGTRSYMSPE------RLQGTHYSVQSDIWS 248 LCDFG+S +L +D +ANS VGT YM+PE L+ Q+D++S Sbjct: 157 DLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLASAMNLENVESFKQTDVYS 216 Query: 249 MGLSLVEM-----AVGRYPI--PPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYG 301 M L L EM AVG PP +K E + + RP P L+ G Sbjct: 217 MALVLWEMTSRCNAVGEVKDYEPPFGSKVREHPCVASMADNVLADAGRPEIPSFWLNHQG 276 Query: 302 MDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDF 337 + M L + ++P +L + + F + Sbjct: 277 IQ----MVCETLTECWDHDPEARLTAQCVAERFSEL 308 >4XCU-A nrPDB Length = 300 Score = 65.5 bits (158), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 54/176 (30%), Positives = 84/176 (47%), Gaps = 18/176 (10%) Query: 126 IVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVI--------KGL 177 I+ G +G + + +E G+L + L+ A R P G +S V+ +G+ Sbjct: 85 IINLLGVCTQEGPLYVIVECAAKGNLREFLR-ARRPPGSSEGPLSFPVLVSCAYQVARGM 143 Query: 178 TYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL--IDSMANSFVGTR--SYMSPE 233 YL E K +HRD+ N+LV +K+ DFG++ + ID + G +M+PE Sbjct: 144 QYL-ESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPE 202 Query: 234 RLQGTHYSVQSDIWSMGLSLVEM-AVGRYPIPPPDAKELELMFGCQVEGDAAETPP 288 L Y+ QSD+WS G+ L E+ +G P P +EL F EG + PP Sbjct: 203 ALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEEL---FSLLREGHRMDRPP 255 >3NIE-A nrPDB Length = 429 Score = 65.1 bits (157), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 59/244 (24%), Positives = 104/244 (42%), Gaps = 46/244 (18%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIR-NQIIRELQVLHECNSP 124 D++E +G G+ G V+ K + +A K ++ + I +I+RE+ +L+ S Sbjct: 28 DNYEIKHLIGRGSYGYVYLAYDKNANKNVAIKKVNRMFEDLIDCKRILREITILNRLKSD 87 Query: 125 YIVGFYGAFYSDG-----EISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTY 179 YI+ + + E+ I +E D L ++ K + EQ + + ++ G + Sbjct: 88 YIIRLHDLIIPEDLLKFDELYIVLEIADS-DLKKLFKTPIFLTEQHVKTILYNLLLGEKF 146 Query: 180 LREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL------------------------ 215 + E I+HRD+KP+N L+N +K+CDFG++ + Sbjct: 147 IHES-GIIHRDLKPANCLLNQDCSVKICDFGLARTINSDKDIHIVNDLEEKEENEEPGPH 205 Query: 216 ---IDSMANSFVGTRSYMSPER-LQGTHYSVQSDIWSMGLSLVEMA----------VGRY 261 + S V TR Y +PE L +Y+ DIWS G E+ R+ Sbjct: 206 NKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDIWSTGCIFAELLNMMKSHINNPTNRF 265 Query: 262 PIPP 265 P+ P Sbjct: 266 PLFP 269 >2VWV-A nrPDB Length = 302 Score = 65.1 bits (157), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 73/264 (27%), Positives = 111/264 (42%), Gaps = 41/264 (15%) Query: 65 DDDFEKISE-LGAGNGGVVFKVSHKPSG---LVMARKLIHLEIKPAIRNQIIRELQVLHE 120 D + KI E +GAG G V + K G +A K + R + + E ++ + Sbjct: 14 DVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLSEASIMGQ 73 Query: 121 CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLK-KAGRIPE-QILGKVSIAVIKGLT 178 P I+ G + + I E M+ G+LD L+ G+ Q++G + + G+ Sbjct: 74 FEHPNIIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLR-GIASGMR 132 Query: 179 YLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL----IDSMANSFVGTR---SYMS 231 YL E + HRD+ NILVNS K+ DFG+S L D S +G + + + Sbjct: 133 YLAEMSYV-HRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTETSSLGGKIPIRWTA 191 Query: 232 PERLQGTHYSVQSDIWSMGLSLVE-MAVGRYPI-------------------PPPDAKEL 271 PE + ++ SD WS G+ + E M+ G P PPPD Sbjct: 192 PEAIAFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCPTS 251 Query: 272 --ELMFGCQVEGDAAETPPRPRTP 293 +LM C + A RPR P Sbjct: 252 LHQLMLDCWQKDRNA----RPRFP 271 >5A46-A nrPDB Length = 386 Score = 65.1 bits (157), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 59/184 (32%), Positives = 88/184 (47%), Gaps = 27/184 (14%) Query: 126 IVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIP-------------EQILGK--VS 170 I+ GA DG + + +E+ G+L + L+ A R P EQ+ K VS Sbjct: 108 IINLLGACTQDGPLYVIVEYASKGNLREYLQ-ARRPPGLEYCYNPSHNPEEQLSSKDLVS 166 Query: 171 IA--VIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL--IDSMANSFVGT 226 A V +G+ YL K K +HRD+ N+LV +K+ DFG++ + ID + G Sbjct: 167 CAYQVARGMEYLASK-KCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGR 225 Query: 227 R--SYMSPERLQGTHYSVQSDIWSMGLSLVEM-AVGRYPIPPPDAKELELMFGCQVEGDA 283 +M+PE L Y+ QSD+WS G+ L E+ +G P P +EL F EG Sbjct: 226 LPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEEL---FKLLKEGHR 282 Query: 284 AETP 287 + P Sbjct: 283 MDKP 286 >3BEA-A nrPDB Length = 333 Score = 65.1 bits (157), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 59/217 (27%), Positives = 102/217 (47%), Gaps = 28/217 (12%) Query: 74 LGAGNGGVV-----FKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVL-HECNSPYIV 127 LGAG G V F + + + L +A K++ + ++ EL+++ H IV Sbjct: 54 LGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIV 113 Query: 128 GFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPE--------------QILGKVSIAV 173 GA G + + E+ G L L++ R+ E + L S V Sbjct: 114 NLLGACTHGGPVLVITEYCCYGDLLNFLRRKSRVLETDPAFAIANSTLSTRDLLHFSSQV 173 Query: 174 IKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRS----- 228 +G+ +L K+ I HRDV N+L+ + K+ DFG++ +++ +N V + Sbjct: 174 AQGMAFLASKNCI-HRDVAARNVLLTNGHVAKIGDFGLARDIMND-SNYIVKGNARLPVK 231 Query: 229 YMSPERLQGTHYSVQSDIWSMGLSLVEM-AVGRYPIP 264 +M+PE + Y+VQSD+WS G+ L E+ ++G P P Sbjct: 232 WMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYP 268 >6FER-A nrPDB Length = 309 Score = 65.1 bits (157), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 41/178 (23%), Positives = 79/178 (44%), Gaps = 15/178 (8%) Query: 92 LVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSL 151 +++A K++ + RN ++E++++ P I+ +D + + E+M+ G L Sbjct: 51 VLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDL 110 Query: 152 DQVLKK----------AGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSR 201 +Q L + + L ++ + G+ YL + +HRD+ N LV Sbjct: 111 NQFLSRHEPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLN-FVHRDLATRNCLVGKN 169 Query: 202 GEIKLCDFGVSGQLIDSMANSFVGTR----SYMSPERLQGTHYSVQSDIWSMGLSLVE 255 IK+ DFG+S L G +MS E + ++ SD+W+ G++L E Sbjct: 170 YTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWE 227 >3GQL-A nrPDB Length = 326 Score = 64.7 bits (156), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 59/184 (32%), Positives = 88/184 (47%), Gaps = 27/184 (14%) Query: 126 IVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIP-------------EQILGK--VS 170 I+ GA DG + + +E+ G+L + L+ A R P EQ+ K VS Sbjct: 96 IINLLGACTQDGPLYVIVEYASKGNLREYLQ-ARRPPGLEYCYNPSHNPEEQLSSKDLVS 154 Query: 171 IA--VIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL--IDSMANSFVGT 226 A V +G+ YL K K +HRD+ N+LV +K+ DFG++ + ID + G Sbjct: 155 CAYQVARGMEYLASK-KCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGR 213 Query: 227 R--SYMSPERLQGTHYSVQSDIWSMGLSLVEM-AVGRYPIPPPDAKELELMFGCQVEGDA 283 +M+PE L Y+ QSD+WS G+ L E+ +G P P +EL F EG Sbjct: 214 LPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEEL---FKLLKEGHR 270 Query: 284 AETP 287 + P Sbjct: 271 MDKP 274 >2PSQ-A nrPDB Length = 370 Score = 64.7 bits (156), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 51/183 (27%), Positives = 84/183 (45%), Gaps = 25/183 (13%) Query: 126 IVGFYGAFYSDGEISICMEHMDGGSLDQVLK-----------KAGRIPEQI-----LGKV 169 I+ GA DG + + +E+ G+L + L+ R+PE+ L Sbjct: 149 IINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSC 208 Query: 170 SIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL--IDSMANSFVGTR 227 + + +G+ YL K +HRD+ N+LV +K+ DFG++ + ID + G Sbjct: 209 TYQLARGMEYL-ASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRL 267 Query: 228 --SYMSPERLQGTHYSVQSDIWSMGLSLVEM-AVGRYPIPPPDAKELELMFGCQVEGDAA 284 +M+PE L Y+ QSD+WS G+ + E+ +G P P +EL F EG Sbjct: 268 PVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEEL---FKLLKEGHRM 324 Query: 285 ETP 287 + P Sbjct: 325 DKP 327 >4AT3-A nrPDB Length = 299 Score = 64.7 bits (156), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 63/257 (24%), Positives = 109/257 (42%), Gaps = 33/257 (12%) Query: 60 VGELKDDDFEKISELGAGNGGVVF-----KVSHKPSGLVMARKLIHLEIKPAIRNQIIRE 114 V +K + ELG G G VF + + +++A K + + R RE Sbjct: 7 VQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLK-DASDNARKDFHRE 65 Query: 115 LQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAG-------------RI 161 ++L +IV FYG + + E+M G L++ L+ G + Sbjct: 66 AELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTEL 125 Query: 162 PEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMAN 221 + + ++ + G+ YL +H +HRD+ N LV +K+ DFG+S + S Sbjct: 126 TQSQMLHIAQQIAAGMVYLASQH-FVHRDLATRNCLVGENLLVKIGDFGMSRD-VYSTDY 183 Query: 222 SFVGTRS-----YMSPERLQGTHYSVQSDIWSMGLSLVEM-AVGRYPIPPPDAKELELMF 275 VG + +M PE + ++ +SD+WS+G+ L E+ G+ P E+ Sbjct: 184 YRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEV---I 240 Query: 276 GCQVEGDAAETPPRPRT 292 C +G + RPRT Sbjct: 241 ECITQGRVLQ---RPRT 254 >3TT0-A nrPDB Length = 382 Score = 64.7 bits (156), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 59/184 (32%), Positives = 88/184 (47%), Gaps = 27/184 (14%) Query: 126 IVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIP-------------EQILGK--VS 170 I+ GA DG + + +E+ G+L + L+ A R P EQ+ K VS Sbjct: 137 IINLLGACTQDGPLYVIVEYASKGNLREYLQ-ARRPPGLEYSYNPSHNPEEQLSSKDLVS 195 Query: 171 IA--VIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL--IDSMANSFVGT 226 A V +G+ YL K K +HRD+ N+LV +K+ DFG++ + ID + G Sbjct: 196 CAYQVARGMEYLASK-KCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGR 254 Query: 227 R--SYMSPERLQGTHYSVQSDIWSMGLSLVEM-AVGRYPIPPPDAKELELMFGCQVEGDA 283 +M+PE L Y+ QSD+WS G+ L E+ +G P P +EL F EG Sbjct: 255 LPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEEL---FKLLKEGHR 311 Query: 284 AETP 287 + P Sbjct: 312 MDKP 315 >1FVR-A nrPDB Length = 327 Score = 64.3 bits (155), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 62/218 (28%), Positives = 98/218 (44%), Gaps = 25/218 (11%) Query: 60 VGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVM---ARKLIHLEIKPAIRNQIIRELQ 116 V + D F+ + +G GN G V K K GL M +++ K R+ EL+ Sbjct: 21 VLDWNDIKFQDV--IGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRD-FAGELE 77 Query: 117 VLHEC-NSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKK----------------AG 159 VL + + P I+ GA G + + +E+ G+L L+K A Sbjct: 78 VLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTAS 137 Query: 160 RIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVS-GQLIDS 218 + Q L + V +G+ YL +K + +HRD+ NILV K+ DFG+S GQ + Sbjct: 138 TLSSQQLLHFAADVARGMDYLSQK-QFIHRDLAARNILVGENYVAKIADFGLSRGQEVYV 196 Query: 219 MANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEM 256 +M+ E L + Y+ SD+WS G+ L E+ Sbjct: 197 KKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEI 234 >6FEX-A nrPDB Length = 321 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 45/182 (24%), Positives = 81/182 (44%), Gaps = 18/182 (9%) Query: 92 LVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSL 151 L++A K++ + RN ++E++++ P I+ G D + + ++M+ G L Sbjct: 58 LLVAVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDL 117 Query: 152 DQVLK------KAGR-------IPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILV 198 +Q L KA I +L V+ + G+ YL +HRD+ N LV Sbjct: 118 NQFLSAHQLEDKAAEGAPGDPTISYPMLLHVAAQIASGMRYL-ATLNFVHRDLATRNCLV 176 Query: 199 NSRGEIKLCDFGVSGQLIDSMANSFVGTR----SYMSPERLQGTHYSVQSDIWSMGLSLV 254 IK+ DFG+S L G +M+ E + ++ SD+W+ G++L Sbjct: 177 GENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLW 236 Query: 255 EM 256 E+ Sbjct: 237 EV 238 >5L6P-A nrPDB Length = 298 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 59/207 (28%), Positives = 99/207 (47%), Gaps = 16/207 (7%) Query: 70 KISE-LGAGNGGVVFKVSHKPSG---LVMARKLIHLEIKPAIRNQIIRELQVLHECNSPY 125 KI E +GAG G V + K G + +A K + + R + E ++ + + P Sbjct: 22 KIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQRRDFLSEASIMGQFDHPN 81 Query: 126 IVGFYGAFYSDGEISICMEHMDGGSLDQVLK-KAGRIPE-QILGKVSIAVIKGLTYLREK 183 I+ G + I E M+ +LD L+ G+ Q++G + + G+ YL E Sbjct: 82 IIRLEGVVTKSRPVMILTEFMENCALDSFLRLNDGQFTVIQLVGMLR-GIAAGMKYLSEM 140 Query: 184 HKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMAN----SFVGTR---SYMSPERLQ 236 + + HRD+ NILVNS K+ DFG+S L D ++ S +G + + +PE + Sbjct: 141 NYV-HRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTAPEAIA 199 Query: 237 GTHYSVQSDIWSMGLSLVE-MAVGRYP 262 ++ SD+WS G+ + E M+ G P Sbjct: 200 YRKFTSASDVWSYGIVMWEVMSYGERP 226 >5Y86-A nrPDB Length = 588 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 59/209 (28%), Positives = 99/209 (47%), Gaps = 13/209 (6%) Query: 68 FEKISELGAGNGGVVFKV-SHKPS---GLVMAR--KLIHLEIKPAIRNQIIRELQVLHEC 121 +E + +G G+ G V +V HK L M R K H + IR I+ L+ + Sbjct: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIR--ILEHLKKQDKT 266 Query: 122 NSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLK-KAGRIPEQILGKVSIAVIKGLTYL 180 S ++ +F + + E + + + K K Q++ K + ++++ L L Sbjct: 267 GSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDAL 326 Query: 181 REKHKIMHRDVKPSNILV--NSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGT 238 K+KI+H D+KP NIL+ + R K+ DFG S + +++ +R Y +PE + G+ Sbjct: 327 -HKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLY-TYIQSRFYRAPEIILGS 384 Query: 239 HYSVQSDIWSMGLSLVEMAVGRYPIPPPD 267 YS DIWS G L E+ G+ P D Sbjct: 385 RYSTPIDIWSFGCILAELLTGQPLFPGED 413 >3C1X-A nrPDB Length = 373 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 48/193 (24%), Positives = 92/193 (47%), Gaps = 19/193 (9%) Query: 97 KLIHLEIKPAIR-------NQIIRELQVLHECNSPYIVGFYG-AFYSDGEISICMEHMDG 148 K IH +K R +Q + E ++ + + P ++ G S+G + + +M Sbjct: 116 KKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKH 175 Query: 149 GSLDQVLKKAGRIP--EQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKL 206 G L ++ P + ++G + V KG+ +L K K +HRD+ N +++ + +K+ Sbjct: 176 GDLRNFIRNETHNPTVKDLIG-FGLQVAKGMKFLASK-KFVHRDLAARNCMLDEKFTVKV 233 Query: 207 CDFGVSGQLIDSMANSF---VGTR---SYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGR 260 DFG++ + D +S G + +M+ E LQ ++ +SD+WS G+ L E+ Sbjct: 234 ADFGLARDMYDKEFDSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRG 293 Query: 261 YPIPPPDAKELEL 273 P P PD ++ Sbjct: 294 AP-PYPDVNTFDI 305 >1NY3-A nrPDB Length = 400 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 77/309 (24%), Positives = 128/309 (41%), Gaps = 51/309 (16%) Query: 66 DDFEKISE-LGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSP 124 DD++ S+ LG G G V ++ +K + A K+ L+ P R ++ + + Sbjct: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKM--LQDCPKARREVELHWRASQCPHIV 118 Query: 125 YIVGFYGAFYSDGE-ISICMEHMDGGSLDQVLKKAG--RIPEQILGKVSIAVIKGLTYLR 181 IV Y Y+ + + I ME +DGG L ++ G E+ ++ ++ + + YL Sbjct: 119 RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 178 Query: 182 EKHKIMHRDVKPSNILVNSR---GEIKLCDFGVSGQLIDSMANSFVG---TRSYMSPERL 235 + I HRDVKP N+L S+ +KL DFG + + + NS T Y++PE L Sbjct: 179 SIN-IAHRDVKPENLLYTSKRPNAILKLTDFGFAKE--TTSHNSLTTPCYTPYYVAPEVL 235 Query: 236 QGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGR 295 Y D+WS+G+ + + G PP G Sbjct: 236 GPEKYDKSCDMWSLGVIMYILLCG--------------------------YPPFYSNHGL 269 Query: 296 PLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQL 355 +S GM +R M +E P P+ S E + + L P +R + + Sbjct: 270 AISP-GMKTRIRMGQYEF-------PNPEWSE--VSEEVKMLIRNLLKTEPTQRMTITEF 319 Query: 356 MVHAFIKRS 364 M H +I +S Sbjct: 320 MNHPWIMQS 328 >5HLW-A nrPDB Length = 299 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 49/193 (25%), Positives = 91/193 (47%), Gaps = 19/193 (9%) Query: 97 KLIHLEIKPAIR-------NQIIRELQVLHECNSPYIVGFYG-AFYSDGEISICMEHMDG 148 K IH +K R +Q + E ++ + + P ++ G S+G + + +M Sbjct: 47 KKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKH 106 Query: 149 GSLDQVLKKAGRIP--EQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKL 206 G L ++ P + ++G + V KG+ YL K K +HRD+ N +++ + +K+ Sbjct: 107 GDLRNFIRNETHNPTVKDLIG-FGLQVAKGMKYLASK-KFVHRDLAARNCMLDEKFTVKV 164 Query: 207 CDFGVSGQLIDSMANSF---VGTR---SYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGR 260 DFG++ + D S G + +M+ E LQ ++ +SD+WS G+ L E+ Sbjct: 165 ADFGLARDMHDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRG 224 Query: 261 YPIPPPDAKELEL 273 P P PD ++ Sbjct: 225 AP-PYPDVNTFDI 236 >2OZA-A nrPDB Length = 356 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 77/309 (24%), Positives = 128/309 (41%), Gaps = 51/309 (16%) Query: 66 DDFEKISE-LGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSP 124 DD++ S+ LG G G V ++ +K + A K+ L+ P R ++ + + Sbjct: 17 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKM--LQDCPKARREVELHWRASQCPHIV 74 Query: 125 YIVGFYGAFYSDGE-ISICMEHMDGGSLDQVLKKAG--RIPEQILGKVSIAVIKGLTYLR 181 IV Y Y+ + + I ME +DGG L ++ G E+ ++ ++ + + YL Sbjct: 75 RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 134 Query: 182 EKHKIMHRDVKPSNILVNSR---GEIKLCDFGVSGQLIDSMANSFVG---TRSYMSPERL 235 + I HRDVKP N+L S+ +KL DFG + + + NS T Y++PE L Sbjct: 135 SIN-IAHRDVKPENLLYTSKRPNAILKLTDFGFAKE--TTSHNSLTTPCYTPYYVAPEVL 191 Query: 236 QGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGR 295 Y D+WS+G+ + + G PP G Sbjct: 192 GPEKYDKSCDMWSLGVIMYILLCG--------------------------YPPFYSNHGL 225 Query: 296 PLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQL 355 +S GM +R M +E P P+ S E + + L P +R + + Sbjct: 226 AISP-GMKTRIRMGQYEF-------PNPEWSE--VSEEVKMLIRNLLKTEPTQRMTITEF 275 Query: 356 MVHAFIKRS 364 M H +I +S Sbjct: 276 MNHPWIMQS 284 >2VZ6-A nrPDB Length = 313 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 69/300 (23%), Positives = 122/300 (40%), Gaps = 47/300 (15%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQII-RELQVLHECNSPYI 126 ++ ELG G VV + +G A K+I+ + A +Q + RE ++ P I Sbjct: 24 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 83 Query: 127 VGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKI 186 V + + +G + + + GG L + + E +++ + + + + Sbjct: 84 VRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQM-GV 142 Query: 187 MHRDVKPSNILVNSR---GEIKLCDFGVSGQLIDSMAN--SFVGTRSYMSPERLQGTHYS 241 +HRD+KP N+L+ S+ +KL DFG++ ++ F GT Y+SPE L+ Y Sbjct: 143 VHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYG 202 Query: 242 VQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYG 301 D+W+ G+ L + VG P D L Q++ A + P S Sbjct: 203 KPVDLWACGVILYILLVGYPPFWDEDQHRLYQ----QIKAGAYDFP-----------SPE 247 Query: 302 MDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFI 361 D+ P E +D +NK L NP++R + + H +I Sbjct: 248 WDTVTP-------------------------EAKDLINKMLTINPSKRITAAEALKHPWI 282 >3KA0-A nrPDB Length = 320 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 77/309 (24%), Positives = 128/309 (41%), Gaps = 51/309 (16%) Query: 66 DDFEKISE-LGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSP 124 DD++ S+ LG G G V ++ +K + A K+ L+ P R ++ + + Sbjct: 15 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKM--LQDCPKARREVELHWRASQCPHIV 72 Query: 125 YIVGFYGAFYSDGE-ISICMEHMDGGSLDQVLKKAG--RIPEQILGKVSIAVIKGLTYLR 181 IV Y Y+ + + I ME +DGG L ++ G E+ ++ ++ + + YL Sbjct: 73 RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 132 Query: 182 EKHKIMHRDVKPSNILVNSR---GEIKLCDFGVSGQLIDSMANSFVG---TRSYMSPERL 235 + I HRDVKP N+L S+ +KL DFG + + + NS T Y++PE L Sbjct: 133 SIN-IAHRDVKPENLLYTSKRPNAILKLTDFGFAKE--TTSHNSLTEPCYTPYYVAPEVL 189 Query: 236 QGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGR 295 Y D+WS+G+ + + G PP G Sbjct: 190 GPEKYDKSCDMWSLGVIMYILLCG--------------------------YPPFYSNHGL 223 Query: 296 PLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQL 355 +S GM +R M +E P P+ S E + + L P +R + + Sbjct: 224 AISP-GMKTRIRMGQYEF-------PNPEWSE--VSEEVKMLIRNLLKTEPTQRMTITEF 273 Query: 356 MVHAFIKRS 364 M H +I +S Sbjct: 274 MNHPWIMQS 282 >5U6Y-A nrPDB Length = 461 Score = 62.8 bits (151), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 69/300 (23%), Positives = 122/300 (40%), Gaps = 47/300 (15%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQII-RELQVLHECNSPYI 126 ++ ELG G VV + +G A K+I+ + A +Q + RE ++ P I Sbjct: 2 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 61 Query: 127 VGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKI 186 V + + +G + + + GG L + + E +++ + + + + Sbjct: 62 VRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQM-GV 120 Query: 187 MHRDVKPSNILVNSR---GEIKLCDFGVSGQLIDSMAN--SFVGTRSYMSPERLQGTHYS 241 +HRD+KP N+L+ S+ +KL DFG++ ++ F GT Y+SPE L+ Y Sbjct: 121 VHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYG 180 Query: 242 VQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYG 301 D+W+ G+ L + VG P D L Q++ A + P S Sbjct: 181 KPVDLWACGVILYILLVGYPPFWDEDQHRLYQ----QIKAGAYDFP-----------SPE 225 Query: 302 MDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFI 361 D+ P E +D +NK L NP++R + + H +I Sbjct: 226 WDTVTP-------------------------EAKDLINKMLTINPSKRITAAEALKHPWI 260 >2QKW-B nrPDB Length = 321 Score = 62.8 bits (151), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 50/161 (31%), Positives = 80/161 (49%), Gaps = 13/161 (8%) Query: 121 CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIP------EQILGKVSIAVI 174 C P++V G E+ + ++M+ G+L + L + +P EQ L ++ I Sbjct: 92 CRHPHLVSLIGFCDERNEMILIYKYMENGNLKRHLYGSD-LPTMSMSWEQRL-EICIGAA 149 Query: 175 KGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVS--GQLIDSMANSFV--GTRSYM 230 +GL YL + I+HRDVK NIL++ K+ DFG+S G +D S V GT Y+ Sbjct: 150 RGLHYLHTR-AIIHRDVKSINILLDENFVPKITDFGISKKGTELDQTHLSTVVKGTLGYI 208 Query: 231 SPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKEL 271 PE + +SD++S G+ L E+ R I +E+ Sbjct: 209 DPEYFIKGRLTEKSDVYSFGVVLFEVLCARSAIVQSLPREM 249 >4NIF-A nrPDB Length = 333 Score = 62.8 bits (151), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 58/207 (28%), Positives = 98/207 (47%), Gaps = 17/207 (8%) Query: 74 LGAGNGGVVFKVSHKPSGLVMARKLIHLEIK-PAIRNQIIRELQVLHECNSPYIVGFYGA 132 +G G+ + HK + + A K+I + P+ +I+ L P I+ Sbjct: 16 IGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIEIL-----LRYGQHPNIITLKDV 70 Query: 133 FYSDGEISICMEHMDGGSL-DQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDV 191 + + + E M GG L D++L++ E+ V + K + YL + ++HRD+ Sbjct: 71 YDDGKHVYLVTELMRGGELLDKILRQK-FFSEREASFVLHTIGKTVEYLHSQ-GVVHRDL 128 Query: 192 KPSNIL-VNSRGE---IKLCDFGVSGQLI--DSMANSFVGTRSYMSPERLQGTHYSVQSD 245 KPSNIL V+ G +++CDFG + QL + + + T ++++PE L+ Y D Sbjct: 129 KPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCD 188 Query: 246 IWSMGLSLVEMAVGRYPIP--PPDAKE 270 IWS+G+ L M G P P D E Sbjct: 189 IWSLGILLYTMLAGYTPFANGPSDTPE 215 >5M07-A nrPDB Length = 276 Score = 62.8 bits (151), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 53/207 (25%), Positives = 94/207 (45%), Gaps = 27/207 (13%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIH--LEIKPAIRNQIIRELQVLHECNSPY 125 + + LGA G V+ V H A K++ + R + RE +V P+ Sbjct: 32 YTVVRMLGASAMGEVYLVQHPGFPGWQALKVLSPAMAADDEFRRRFQRETEVAARLFHPH 91 Query: 126 IVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPE-----QILGKVSIAVIKGLTYL 180 I+ + DG++ I M+++DG +D A R P ++L V+ AV L Y Sbjct: 92 ILEVHDRGEFDGQLWIAMDYVDG--IDATQHMADRFPAVLPVGEVLAIVT-AVAGALDYA 148 Query: 181 REKHKIMHRDVKPSNILVNSRG----EIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQ 236 ++ ++HRDV P+N+++ S+ I L DFG++ Q SY +PE Sbjct: 149 HQR-GLLHRDVNPANVVLTSQSAGDQRILLADFGIASQ------------PSYPAPELSA 195 Query: 237 GTHYSVQSDIWSMGLSLVEMAVGRYPI 263 G ++D +++ L+ + + G P+ Sbjct: 196 GADVDGRADQYALALTAIHLFAGAPPV 222 >5EG3-A nrPDB Length = 334 Score = 62.8 bits (151), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 50/183 (27%), Positives = 83/183 (45%), Gaps = 25/183 (13%) Query: 126 IVGFYGAFYSDGEISICMEHMDGGSLDQVLK-----------KAGRIPEQI-----LGKV 169 I+ GA DG + + + + G+L + L+ R+PE+ L Sbjct: 103 IINLLGACTQDGPLYVIVAYASKGNLREYLRARRPPGMELSPDINRVPEEQMTFKDLVSC 162 Query: 170 SIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL--IDSMANSFVGTR 227 + + +G+ YL K +HRD+ N+LV +K+ DFG++ + ID + G Sbjct: 163 TYQLARGMEYL-ASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDFFKETTNGRL 221 Query: 228 --SYMSPERLQGTHYSVQSDIWSMGLSLVEM-AVGRYPIPPPDAKELELMFGCQVEGDAA 284 +M+PE L Y+ QSD+WS G+ + E+ +G P P +EL F EG Sbjct: 222 PVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEEL---FKLLKEGHRM 278 Query: 285 ETP 287 + P Sbjct: 279 DKP 281 >4EBW-A nrPDB Length = 304 Score = 62.8 bits (151), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 53/204 (25%), Positives = 95/204 (46%), Gaps = 13/204 (6%) Query: 62 ELKDDDFEKISELGAGNGGVVFK---VSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVL 118 E++ + E +G G G V + +S + L +A K ++R + ++E + Sbjct: 34 EIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTM 93 Query: 119 HECNSPYIVGFYGAFYSDGEISICMEHMDGGSLD---QVLKKAGRIPEQILGKVSIAVIK 175 + + P+IV G ++ + I ME G L QV K + + IL ++ Sbjct: 94 RQFDHPHIVKLIGVI-TENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLST-- 150 Query: 176 GLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTR---SYMSP 232 L YL E + +HRD+ N+LV+S +KL DFG+S + DS + +M+P Sbjct: 151 ALAYL-ESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAP 209 Query: 233 ERLQGTHYSVQSDIWSMGLSLVEM 256 E + ++ SD+W G+ + E+ Sbjct: 210 ESINFRRFTSASDVWMFGVCMWEI 233 >5KMM-A nrPDB Length = 329 Score = 62.8 bits (151), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 60/222 (27%), Positives = 97/222 (43%), Gaps = 28/222 (12%) Query: 60 VGELKDDDFEKISELGAGNGGVVF-----KVSHKPSGLVMARKLIHLEIKPAIRNQIIRE 114 V +K D ELG G G VF + + +++A K + E + R RE Sbjct: 29 VHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALK-EASESARQDFQRE 87 Query: 115 LQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIA-- 172 ++L +IV F+G + + E+M G L++ L+ G + + G +A Sbjct: 88 AELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPG 147 Query: 173 -------------VIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSM 219 V G+ YL H +HRD+ N LV +K+ DFG+S + I S Sbjct: 148 PLGLGQLLAVASQVAAGMVYLAGLH-FVHRDLATRNCLVGQGLVVKIGDFGMS-RDIYST 205 Query: 220 ANSFVGTRS-----YMSPERLQGTHYSVQSDIWSMGLSLVEM 256 VG R+ +M PE + ++ +SD+WS G+ L E+ Sbjct: 206 DYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEI 247 >4XUF-A nrPDB Length = 297 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 64/240 (26%), Positives = 106/240 (44%), Gaps = 43/240 (17%) Query: 74 LGAGNGGVV-----FKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNS-PYIV 127 LG+G G V + +S + +A K++ + + R ++ EL+++ + S IV Sbjct: 17 LGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIV 76 Query: 128 GFYGAFYSDGEISICMEHMDGGSLDQVLK--------------KAGRIPEQ--------- 164 GA G I + E+ G L L+ R+ E+ Sbjct: 77 NLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRLEEEEDLNVLTFE 136 Query: 165 ILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFV 224 L + V KG+ +L E +HRD+ N+LV +K+CDFG++ D M++S Sbjct: 137 DLLCFAYQVAKGMEFL-EFKSCVHRDLAARNVLVTHGKVVKICDFGLAR---DIMSDSNY 192 Query: 225 GTR-------SYMSPERLQGTHYSVQSDIWSMGLSLVE---MAVGRYPIPPPDAKELELM 274 R +M+PE L Y+++SD+WS G+ L E + V YP P DA +L+ Sbjct: 193 VVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLI 252 >2OGV-A nrPDB Length = 317 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 60/213 (28%), Positives = 102/213 (47%), Gaps = 24/213 (11%) Query: 74 LGAGNGGVV-----FKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVL-HECNSPYIV 127 LGAG G V F + + + L +A K++ + ++ EL+++ H IV Sbjct: 46 LGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIV 105 Query: 128 GFYGAFYSDGEISICMEHMDGGSLDQVLKKA---------GRIPE-QILGKVSIAVIKGL 177 GA G + + E+ G L L++ GR E + L S V +G+ Sbjct: 106 NLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEADLDKEDGRPLELRDLLHFSSQVAQGM 165 Query: 178 TYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRS-----YMSP 232 +L K+ I HRDV N+L+ + K+ DFG++ +++ +N V + +M+P Sbjct: 166 AFLASKNCI-HRDVAARNVLLTNGHVAKIGDFGLARDIMND-SNYIVKGNARLPVKWMAP 223 Query: 233 ERLQGTHYSVQSDIWSMGLSLVEM-AVGRYPIP 264 E + Y+VQSD+WS G+ L E+ ++G P P Sbjct: 224 ESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYP 256 >1AD5-A nrPDB Length = 438 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 53/200 (26%), Positives = 95/200 (47%), Gaps = 25/200 (12%) Query: 73 ELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRN--QIIRELQVLHECNSPYIVGFY 130 +LGAG G V+ ++ V + + KP + + E V+ +V + Sbjct: 189 KLGAGQFGEVWMATYNKHTKVAVKTM-----KPGSMSVEAFLAEANVMKTLQHDKLVKLH 243 Query: 131 GAFYSDGEISICMEHMDGGSLDQVLK--KAGRIPEQILGKVSIAVIKGLTYLREKHKIMH 188 A + I I E M GSL LK + + P L S + +G+ ++ +++ I H Sbjct: 244 -AVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYI-H 301 Query: 189 RDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTR---SYMSPERLQGTHYSVQSD 245 RD++ +NILV++ K+ DFG++ VG + + +PE + ++++SD Sbjct: 302 RDLRAANILVSASLVCKIADFGLAR----------VGAKFPIKWTAPEAINFGSFTIKSD 351 Query: 246 IWSMGLSLVEMAV-GRYPIP 264 +WS G+ L+E+ GR P P Sbjct: 352 VWSFGILLMEIVTYGRIPYP 371 >3CJF-A nrPDB Length = 309 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 65/251 (25%), Positives = 109/251 (43%), Gaps = 30/251 (11%) Query: 38 EELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVV-----FKVSHKPSGL 92 +EL LDE + L E D LG G G V F + + Sbjct: 4 DELPLDEHCER-----LPYDASKWEFPRDRLNLGKPLGRGAFGQVIEADAFGIDKTATCR 58 Query: 93 VMARKLIHLEIKPAIRNQIIRELQVL-HECNSPYIVGFYGAFYS-DGEISICMEHMDGGS 150 +A K++ + ++ EL++L H + +V GA G + + +E G+ Sbjct: 59 TVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGN 118 Query: 151 LDQVL--KKAGRIPEQILGK----------VSIAVIKGLTYLREKHKIMHRDVKPSNILV 198 L L K+ +P + L K S V KG+ +L + K +HRD+ NIL+ Sbjct: 119 LSTYLRSKRNEFVPYKDLYKDFLTLEHLICYSFQVAKGMEFLASR-KCIHRDLAARNILL 177 Query: 199 NSRGEIKLCDFGVSGQLIDSMANSFVGTR----SYMSPERLQGTHYSVQSDIWSMGLSLV 254 + + +K+CDFG++ + G +M+PE + Y++QSD+WS G+ L Sbjct: 178 SEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLW 237 Query: 255 EM-AVGRYPIP 264 E+ ++G P P Sbjct: 238 EIFSLGASPYP 248 >5X02-A nrPDB Length = 347 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 64/240 (26%), Positives = 106/240 (44%), Gaps = 43/240 (17%) Query: 74 LGAGNGGVV-----FKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNS-PYIV 127 LG+G G V + +S + +A K++ + + R ++ EL+++ + S IV Sbjct: 56 LGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIV 115 Query: 128 GFYGAFYSDGEISICMEHMDGGSLDQVLK--------------KAGRIPEQ--------- 164 GA G I + E+ G L L+ R+ E+ Sbjct: 116 NLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRLEEEEDLNVLTFE 175 Query: 165 ILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFV 224 L + V KG+ +L E +HRD+ N+LV +K+CDFG++ D M++S Sbjct: 176 DLLCFAYQVAKGMEFL-EFKSCVHRDLAARNVLVTHGKVVKICDFGLAR---DIMSDSNY 231 Query: 225 GTR-------SYMSPERLQGTHYSVQSDIWSMGLSLVE---MAVGRYPIPPPDAKELELM 274 R +M+PE L Y+++SD+WS G+ L E + V YP P DA +L+ Sbjct: 232 VVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLI 291 >3BHH-A nrPDB Length = 295 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 54/212 (25%), Positives = 99/212 (46%), Gaps = 7/212 (3%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQII-RELQVLHECNSP 124 D+++ ++G G VV + +G A K+I+ + A +Q + RE ++ Sbjct: 4 DEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHS 63 Query: 125 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKH 184 IV + + +G + + + GG L + + E +++ + + + Sbjct: 64 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQM- 122 Query: 185 KIMHRDVKPSNILVNSR---GEIKLCDFGVSGQLI-DSMAN-SFVGTRSYMSPERLQGTH 239 ++HRD+KP N+L+ S+ +KL DFG++ ++ D A F GT Y+SPE L+ Sbjct: 123 GVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEA 182 Query: 240 YSVQSDIWSMGLSLVEMAVGRYPIPPPDAKEL 271 Y DIW+ G+ L + VG P D +L Sbjct: 183 YGKPVDIWACGVILYILLVGYPPFWDEDQHKL 214 >4M66-A nrPDB Length = 325 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 57/214 (26%), Positives = 101/214 (47%), Gaps = 29/214 (13%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIH-----LEIKPAI--RNQ-IIRELQV 117 ++ +K+ +G G GVVF+ H+ +A K+++ E+K + RN+ ++ L V Sbjct: 20 EELKKLEFVGKGGFGVVFRAHHRTWNHDVAVKIVNSKKISWEVKAMVNLRNENVLLLLGV 79 Query: 118 LHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGL 177 + ++ G ++ M+ GSL +L+ P +L ++ V+ G+ Sbjct: 80 TEDLQWDFVSG----------QALVTRFMENGSLAGLLQPEAPRPWPLLCRLLQEVVLGM 129 Query: 178 TYLREKHK-IMHRDVKPSNILVNSRGEIKLCDFGVSG--------QLIDSMANSFVGTRS 228 YL ++HRD+KPSNIL++ KL DFG+S S + GT + Sbjct: 130 CYLHSLDPPLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQSGSGSGSGSRDSGGTLA 189 Query: 229 YMSPERLQGTHY--SVQSDIWSMGLSLVEMAVGR 260 Y+ PE L + S SD++S G+ + + GR Sbjct: 190 YLDPELLFKVNLKASKASDVYSFGILVWAVLAGR 223 >4R7H-A nrPDB Length = 343 Score = 62.0 bits (149), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 60/226 (26%), Positives = 104/226 (46%), Gaps = 37/226 (16%) Query: 74 LGAGNGGVV-----FKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVL-HECNSPYIV 127 LGAG G V F + + + L +A K++ + ++ EL+++ H IV Sbjct: 58 LGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIV 117 Query: 128 GFYGAFYSDGEISICMEHMDGGSLDQVLKKA-----------GRIPEQI----------- 165 GA G + + E+ G L L++ G+ PE + Sbjct: 118 NLLGACTHGGPVLVITEYCTYGDLLNFLRRKAEAMLGPSLSPGQDPEGLDKEDGRPLELR 177 Query: 166 -LGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFV 224 L S V +G+ +L K+ I HRDV N+L+ + K+ DFG++ +++ +N V Sbjct: 178 DLLHFSSQVAQGMAFLASKNCI-HRDVAARNVLLTNGHVAKIGDFGLARDIMND-SNYIV 235 Query: 225 GTRS-----YMSPERLQGTHYSVQSDIWSMGLSLVEM-AVGRYPIP 264 + +M+PE + + Y+VQSD+WS G+ L E+ ++G P P Sbjct: 236 KGNARLPVKWMAPESIFDSVYTVQSDVWSYGILLWEIFSLGLNPYP 281 >3PLS-A nrPDB Length = 298 Score = 61.6 bits (148), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 50/198 (25%), Positives = 91/198 (45%), Gaps = 20/198 (10%) Query: 74 LGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIR-------NQIIRELQVLHECNSPYI 126 +G G+ GVV+ + + A+ I IK R +RE ++ N P + Sbjct: 29 IGKGHFGVVYHGEY----IDQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLNHPNV 84 Query: 127 VGFYGAFYS-DGEISICMEHMDGGSLDQVLKKAGRIPE-QILGKVSIAVIKGLTYLREKH 184 + G +G + + +M G L Q ++ R P + L + V +G+ YL E+ Sbjct: 85 LALIGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLAEQ- 143 Query: 185 KIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTR------SYMSPERLQGT 238 K +HRD+ N +++ +K+ DFG++ ++D S R + + E LQ Sbjct: 144 KFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWTALESLQTY 203 Query: 239 HYSVQSDIWSMGLSLVEM 256 ++ +SD+WS G+ L E+ Sbjct: 204 RFTTKSDVWSFGVLLWEL 221 >5UNP-A nrPDB Length = 369 Score = 61.6 bits (148), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 66/238 (27%), Positives = 105/238 (44%), Gaps = 31/238 (13%) Query: 60 VGELKDDDFEKISELGAGN-GGVVFKVSHKPSGLVMARKLIH--LEIKPAIRNQIIRELQ 116 VG+ + +E +S LG G G VV V H+ G +A K+I + K A R +I L+ Sbjct: 28 VGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEI-NVLE 86 Query: 117 VLHEC---NSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQI--LGKVSI 171 ++E N V + F G + I E + + D LK +P I + ++ Sbjct: 87 KINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFD-FLKDNNYLPYPIHQVRHMAF 145 Query: 172 AVIKGLTYLREKHKIMHRDVKPSNIL-VNSRGE------------------IKLCDFGVS 212 + + + +L + K+ H D+KP NIL VNS E +++ DFG S Sbjct: 146 QLCQAVKFLHDN-KLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFG-S 203 Query: 213 GQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKE 270 ++ V TR Y +PE + +S D+WS+G + E VG D +E Sbjct: 204 ATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNRE 261 >4F0G-A nrPDB Length = 287 Score = 61.6 bits (148), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 62/255 (24%), Positives = 119/255 (46%), Gaps = 22/255 (8%) Query: 57 KQKVGELKDDDFEKISELGAGNGGVVFKVSH-KPSGLVMARKLIHLEIKPAIR-----NQ 110 K ++ L D++ E ++G G G+V K K +V + LI + + + Sbjct: 10 KSRLPTLADNEIEYEKQIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQE 69 Query: 111 IIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSL-DQVLKKAGRIPEQILGKV 169 RE+ ++ N P IV YG ++ + ME + G L ++L KA I + ++ Sbjct: 70 FQREVFIMSNLNHPNIVKLYGLMHNPPR--MVMEFVPCGDLYHRLLDKAHPIKWSVKLRL 127 Query: 170 SIAVIKGLTYLREKH-KIMHRDVKPSNILVNSRGE-----IKLCDFGVSGQLIDSMANSF 223 + + G+ Y++ ++ I+HRD++ NI + S E K+ DFG+S Q + S++ Sbjct: 128 MLDIALGIEYMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQSVHSVS-GL 186 Query: 224 VGTRSYMSPERL--QGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEG 281 +G +M+PE + + Y+ ++D +S + L + G P +++ + + EG Sbjct: 187 LGNFQWMAPETIGAEEESYTEKADTYSFAMILYTILTGEGPFDEYSYGKIKFINMIREEG 246 Query: 282 ----DAAETPPRPRT 292 + PPR R Sbjct: 247 LRPTIPEDCPPRLRN 261 >6BSD-A nrPDB Length = 876 Score = 61.6 bits (148), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 43/188 (22%), Positives = 80/188 (42%), Gaps = 24/188 (12%) Query: 92 LVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSL 151 L++A K++ + RN ++E++++ P I+ G D + + ++M+ G L Sbjct: 613 LLVAVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDL 672 Query: 152 DQVLK-------------------KAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVK 192 +Q L + I +L V+ + G+ YL +HRD+ Sbjct: 673 NQFLSAHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYL-ATLNFVHRDLA 731 Query: 193 PSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTR----SYMSPERLQGTHYSVQSDIWS 248 N LV IK+ DFG+S L G +M+ E + ++ SD+W+ Sbjct: 732 TRNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWA 791 Query: 249 MGLSLVEM 256 G++L E+ Sbjct: 792 FGVTLWEV 799 >6GVJ-A nrPDB Length = 429 Score = 61.2 bits (147), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 58/216 (26%), Positives = 101/216 (46%), Gaps = 26/216 (12%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE-----IKPAIRNQIIRELQVLHECN 122 + + ++G+G VF+V ++ + A K ++LE + RN+I L L + + Sbjct: 146 YSILKQIGSGGSSKVFQVLNEKKQ-IYAIKYVNLEEADNQTLDSYRNEIAY-LNKLQQ-H 202 Query: 123 SPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLRE 182 S I+ Y +D I + ME L+ LKK I +++ + + + Sbjct: 203 SDKIIRLYDYEITDQYIYMVME-CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQ 261 Query: 183 KHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL----IDSMANSFVGTRSYMSPERLQGT 238 H I+H D+KP+N L+ G +KL DFG++ Q+ + +S VGT +YM PE ++ Sbjct: 262 -HGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDM 319 Query: 239 HYSVQS-----------DIWSMGLSLVEMAVGRYPI 263 S ++ D+WS+G L M G+ P Sbjct: 320 SSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF 355 >5HI2-A nrPDB Length = 283 Score = 61.2 bits (147), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 58/209 (27%), Positives = 109/209 (52%), Gaps = 17/209 (8%) Query: 62 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHEC 121 E+ D +G+G+ G V+K K G V + L +++ A +N E+ VL + Sbjct: 16 EIPDGQITVGQRIGSGSFGTVYKG--KWHGDVAVKMLTPQQLQ-AFKN----EVGVLRKT 68 Query: 122 NSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKA-GRIPEQILGKVSIAVIKGLTYL 180 I+ F G + + +++I + +G SL L + + + L ++ +G+ YL Sbjct: 69 RHVNILLFMG-YSTKPQLAIVTQWCEGSSLYHHLHASETKFEMKKLIDIARQTARGMDYL 127 Query: 181 REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSG-QLIDSMANSF---VGTRSYMSPE--R 234 K I+HRD+K +NI ++ +K+ DFG++ + S ++ F G+ +M+PE R Sbjct: 128 HAK-SIIHRDLKSNNIFLHEDNTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIR 186 Query: 235 LQGTH-YSVQSDIWSMGLSLVEMAVGRYP 262 +Q ++ YS QSD+++ G+ L E+ G+ P Sbjct: 187 MQDSNPYSFQSDVYAFGIVLYELMTGQLP 215 >3G0E-A nrPDB Length = 336 Score = 61.2 bits (147), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 62/233 (26%), Positives = 104/233 (44%), Gaps = 34/233 (14%) Query: 74 LGAGNGGVVFKVS-----HKPSGLVMARKLIHLEIKPAIRNQIIRELQVL-HECNSPYIV 127 LGAG G V + + + + +A K++ R ++ EL+VL + N IV Sbjct: 54 LGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIV 113 Query: 128 GFYGAFYSDGEISICMEHMDGGSLDQVLKK------AGRIPEQILG------------KV 169 GA G + E+ G L L++ + I+ Sbjct: 114 NLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKTSPAIMEDDELALDLEDLLSF 173 Query: 170 SIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRS- 228 S V KG+ +L K+ I HRD+ NIL+ K+CDFG++ I + +N V + Sbjct: 174 SYQVAKGMAFLASKNCI-HRDLAARNILLTHGRITKICDFGLARD-IKNDSNYVVKGNAR 231 Query: 229 ----YMSPERLQGTHYSVQSDIWSMGLSLVEM-AVGRYPIP--PPDAKELELM 274 +M+PE + Y+ +SD+WS G+ L E+ ++G P P P D+K +++ Sbjct: 232 LPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMI 284 >4PDO-A nrPDB Length = 299 Score = 61.2 bits (147), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 54/200 (27%), Positives = 90/200 (45%), Gaps = 12/200 (6%) Query: 74 LGAGNGGVVFKVSHKPSG----LVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGF 129 +GAG G V+K K S + +A K + R + E ++ + + I+ Sbjct: 42 IGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQFSHHNIIRL 101 Query: 130 YGAFYSDGEISICMEHMDGGSLDQVLK-KAGRIPEQILGKVSIAVIKGLTYLREKHKIMH 188 G + I E+M+ G+LD+ L+ K G L + + G+ YL + + H Sbjct: 102 EGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAGMKYLANMNYV-H 160 Query: 189 RDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRS-----YMSPERLQGTHYSVQ 243 RD+ NILVNS K+ DFG+S L D ++ + + +PE + ++ Sbjct: 161 RDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYRKFTSA 220 Query: 244 SDIWSMGLSLVE-MAVGRYP 262 SD+WS G+ + E M G P Sbjct: 221 SDVWSFGIVMWEVMTYGERP 240 >3KRL-A nrPDB Length = 335 Score = 60.8 bits (146), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 59/219 (26%), Positives = 101/219 (46%), Gaps = 30/219 (13%) Query: 74 LGAGNGGVV-----FKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVL-HECNSPYIV 127 LGAG G V F + + + L +A K++ + ++ EL+++ H IV Sbjct: 54 LGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIV 113 Query: 128 GFYGAFYSDGEISICMEHMDGGSLDQVLKKA-----------GRIPEQILGK-----VSI 171 GA G + + E+ G L L++ PE+ L S Sbjct: 114 NLLGACTHGGPVLVITEYCCYGDLLNFLRRKRPPGLEYSYNPSHNPEEQLSSRDLLHFSS 173 Query: 172 AVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRS--- 228 V +G+ +L K+ I HRDV N+L+ + K+ DFG++ +++ +N V + Sbjct: 174 QVAQGMAFLASKNCI-HRDVAARNVLLTNGHVAKIGDFGLARDIMND-SNYIVKGNARLP 231 Query: 229 --YMSPERLQGTHYSVQSDIWSMGLSLVEM-AVGRYPIP 264 +M+PE + Y+VQSD+WS G+ L E+ ++G P P Sbjct: 232 VKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYP 270 >3VHK-A nrPDB Length = 368 Score = 60.8 bits (146), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 33/100 (33%), Positives = 56/100 (56%), Gaps = 6/100 (6%) Query: 170 SIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTR-- 227 S V KG+ +L + K +HRD+ NIL++ + +K+CDFG++ + G Sbjct: 206 SFQVAKGMEFLASR-KCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARL 264 Query: 228 --SYMSPERLQGTHYSVQSDIWSMGLSLVEM-AVGRYPIP 264 +M+PE + Y++QSD+WS G+ L E+ ++G P P Sbjct: 265 PLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYP 304 >2J0K-A nrPDB Length = 656 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 42/157 (26%), Positives = 77/157 (49%), Gaps = 10/157 (6%) Query: 106 AIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLD---QVLKKAGRIP 162 ++R + ++E + + + P+IV G ++ + I ME G L QV K + + Sbjct: 433 SVREKFLQEALTMRQFDHPHIVKLIGVI-TENPVWIIMELCTLGELRSFLQVRKFSLDLA 491 Query: 163 EQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANS 222 IL ++ L YL E + +HRD+ N+LV++ +KL DFG+S + DS Sbjct: 492 SLILYAYQLST--ALAYL-ESKRFVHRDIAARNVLVSATDCVKLGDFGLSRYMEDSTYYK 548 Query: 223 FVGTR---SYMSPERLQGTHYSVQSDIWSMGLSLVEM 256 + +M+PE + ++ SD+W G+ + E+ Sbjct: 549 ASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEI 585 >4RT7-A nrPDB Length = 415 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 54/173 (31%), Positives = 88/173 (50%), Gaps = 22/173 (12%) Query: 113 RELQVLHECNSPYIVGFYG-AFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSI 171 RE+Q+ +S I G +G +F+S+ EI E+ + L++ E +L + Sbjct: 198 REVQI--HPDSDQISGLHGNSFHSEDEI----EYENQKRLEEEEDLNVLTFEDLLC-FAY 250 Query: 172 AVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTR---- 227 V KG+ +L K +HRD+ N+LV +K+CDFG++ D M++S R Sbjct: 251 QVAKGMEFLEFK-SCVHRDLAARNVLVTHGKVVKICDFGLAR---DIMSDSNYVVRGNAR 306 Query: 228 ---SYMSPERLQGTHYSVQSDIWSMGLSLVE---MAVGRYPIPPPDAKELELM 274 +M+PE L Y+++SD+WS G+ L E + V YP P DA +L+ Sbjct: 307 LPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLI 359 >3KUL-B nrPDB Length = 325 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 46/162 (28%), Positives = 75/162 (46%), Gaps = 8/162 (4%) Query: 108 RNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKA-GRIPEQIL 166 R + E ++ + + P I+ G I E+M+ GSLD L+ G+ L Sbjct: 94 RRDFLSEASIMGQFDHPNIIRLEGVVTRGRLAMIVTEYMENGSLDTFLRTHDGQFTIMQL 153 Query: 167 GKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGT 226 + V G+ YL + + HRD+ N+LV+S K+ DFG+S L D ++ T Sbjct: 154 VGMLRGVGAGMRYLSDLGYV-HRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTT 212 Query: 227 RS-----YMSPERLQGTHYSVQSDIWSMGLSLVE-MAVGRYP 262 + +PE + +S SD+WS G+ + E +A G P Sbjct: 213 GGKIPIRWTAPEAIAFRTFSSASDVWSFGVVMWEVLAYGERP 254 >6CKI-A nrPDB Length = 316 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 67/274 (24%), Positives = 117/274 (42%), Gaps = 44/274 (16%) Query: 107 IRNQIIRELQVLHECNSPYIVGFYGAFYSDGE-ISICMEHMDGGSLDQVLKKAGRIPEQI 165 IR+++ RE+++L++C V F+ + + + E M GGS+ + K E Sbjct: 53 IRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELE 112 Query: 166 LGKVSIAVIKGLTYLREKHKIMHRDVKPSNILV---NSRGEIKLCDFGV-SGQLIDSMAN 221 V V L +L K I HRD+KP NIL N +K+CDFG+ SG ++ + Sbjct: 113 ASVVVQDVASALDFLHNK-GIAHRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCS 171 Query: 222 SF--------VGTRSYMSPERLQG-----THYSVQSDIWSMGLSLVEMAVGRYPIPPPDA 268 G+ YM+PE ++ + Y + D+WS+G+ L + G PP Sbjct: 172 PISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSG---YPPFVG 228 Query: 269 KELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSG 328 + G D E P + +FE + E P K + Sbjct: 229 R-----CGSDCGWDRGEACPACQN----------------MLFESIQEGKYEFPDKDWAH 267 Query: 329 VFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIK 362 + S +D ++K L+++ +R Q++ H +++ Sbjct: 268 I-SCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQ 300 >3OMV-A nrPDB Length = 307 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 57/200 (28%), Positives = 98/200 (49%), Gaps = 14/200 (7%) Query: 72 SELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYG 131 + +G+G+ G V+K K G V + L ++ P E+ VL + I+ F G Sbjct: 42 TRIGSGSFGTVYK--GKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMG 99 Query: 132 AFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIA--VIKGLTYLREKHKIMHR 189 D ++I + +G SL + L Q+ + IA +G+ YL K+ I+HR Sbjct: 100 YMTKDN-LAIVTQWCEGSSLYKHLH-VQETKFQMFQLIDIARQTAQGMDYLHAKN-IIHR 156 Query: 190 DVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFV----GTRSYMSPE--RLQGTH-YSV 242 D+K +NI ++ +K+ DFG++ + V G+ +M+PE R+Q + +S Sbjct: 157 DMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSF 216 Query: 243 QSDIWSMGLSLVEMAVGRYP 262 QSD++S G+ L E+ G P Sbjct: 217 QSDVYSYGIVLYELMTGELP 236 >3SOA-A nrPDB Length = 444 Score = 60.1 bits (144), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 67/302 (22%), Positives = 123/302 (40%), Gaps = 47/302 (15%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQII-RELQVLHECNSP 124 ++++ ELG G VV + +G A +I+ + A +Q + RE ++ P Sbjct: 11 EEYQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDHQKLEREARICRLLKHP 70 Query: 125 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKH 184 IV + + +G + + + GG L + + E +++ + + + Sbjct: 71 NIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQM- 129 Query: 185 KIMHRDVKPSNILVNSR---GEIKLCDFGVSGQLIDSMAN--SFVGTRSYMSPERLQGTH 239 ++HR++KP N+L+ S+ +KL DFG++ ++ F GT Y+SPE L+ Sbjct: 130 GVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDP 189 Query: 240 YSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSS 299 Y D+W+ G+ L + VG P D L Q++ A + P S Sbjct: 190 YGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQ----QIKAGAYDFP-----------S 234 Query: 300 YGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHA 359 D+ P E +D +NK L NP++R + + H Sbjct: 235 PEWDTVTP-------------------------EAKDLINKMLTINPSKRITAAEALKHP 269 Query: 360 FI 361 +I Sbjct: 270 WI 271 >3HMP-A nrPDB Length = 342 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 58/218 (26%), Positives = 102/218 (46%), Gaps = 30/218 (13%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE-----IKPAIRNQI--IRELQVLHE 120 + + ++G+G VF+V ++ + A K ++LE + RN+I + +LQ Sbjct: 58 YSILKQIGSGGSSKVFQVLNEKKQ-IYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQ--- 113 Query: 121 CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL 180 +S I+ Y +D I + ME L+ LKK I +++ + + Sbjct: 114 -HSDKIIRLYDYEITDQYIYMVME-CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTI 171 Query: 181 REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL----IDSMANSFVGTRSYMSPERLQ 236 + H I+H D+KP+N L+ G +KL DFG++ Q+ + +S VGT +YM PE ++ Sbjct: 172 HQ-HGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIK 229 Query: 237 GTHYSVQS-----------DIWSMGLSLVEMAVGRYPI 263 S ++ D+WS+G L M G+ P Sbjct: 230 DMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF 267 >3I81-A nrPDB Length = 315 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 58/214 (27%), Positives = 96/214 (44%), Gaps = 29/214 (13%) Query: 69 EKIS---ELGAGNGGVVFK------VSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLH 119 EKI+ ELG G+ G+V++ V +P V A K ++ R + + E V+ Sbjct: 18 EKITMSRELGQGSFGMVYEGVAKGVVKDEPETRV-AIKTVNEAASMRERIEFLNEASVMK 76 Query: 120 ECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQ----ILGKVSIA--- 172 E N ++V G + ME M G L L+ PE +L S++ Sbjct: 77 EFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLR--PEMENNPVLAPPSLSKMI 134 Query: 173 -----VIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGT- 226 + G+ YL +K +HRD+ N +V +K+ DFG++ + ++ G Sbjct: 135 QMAGEIADGMAYLN-ANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKG 193 Query: 227 ---RSYMSPERLQGTHYSVQSDIWSMGLSLVEMA 257 +MSPE L+ ++ SD+WS G+ L E+A Sbjct: 194 LLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIA 227 >4H1J-A nrPDB Length = 293 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 53/198 (26%), Positives = 88/198 (44%), Gaps = 10/198 (5%) Query: 74 LGAGNGGVVFK---VSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFY 130 LG G G V++ +HK + +A K + + + + E ++ + P+IV Sbjct: 32 LGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHIVKLI 91 Query: 131 GAFYSDGEISICMEHMDGGSLDQVLKK-AGRIPEQILGKVSIAVIKGLTYLREKHKIMHR 189 G + I ME G L L++ + L S+ + K + YL E +HR Sbjct: 92 GII-EEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYL-ESINCVHR 149 Query: 190 DVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTR---SYMSPERLQGTHYSVQSDI 246 D+ NILV S +KL DFG+S + D TR +MSPE + ++ SD+ Sbjct: 150 DIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPESINFRRFTTASDV 209 Query: 247 WSMGLSLVE-MAVGRYPI 263 W + + E ++ G+ P Sbjct: 210 WMFAVCMWEILSFGKQPF 227 >4X7Q-B nrPDB Length = 312 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 37/102 (36%), Positives = 51/102 (50%), Gaps = 3/102 (2%) Query: 186 IMHRDVKPSNILVN-SRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY-SVQ 243 ++HRD+K NIL++ RG KL DFG L D F GTR Y PE + Y ++ Sbjct: 160 VVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALP 219 Query: 244 SDIWSMGLSLVEMAVGRYPIP-PPDAKELELMFGCQVEGDAA 284 + +WS+G+ L +M G P + E EL F V D Sbjct: 220 ATVWSLGILLYDMVCGDIPFERDQEILEAELHFPAHVSPDCC 261 >3LLT-A nrPDB Length = 360 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 65/234 (27%), Positives = 101/234 (43%), Gaps = 39/234 (16%) Query: 59 KVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRN-----QIIR 113 K G L ++ F I ++G G G V H + A K++ IK R+ I++ Sbjct: 28 KKGMLLNNAFLVIRKMGDGTFGRVLLCQHIDNKKYYAVKVVR-NIKKYTRSAKIEADILK 86 Query: 114 ELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQI--LGKVSI 171 ++Q N+ IV ++G F + + E + G SL +++ + I + I Sbjct: 87 KIQNDDINNNN-IVKYHGKFMYYDHMCLIFEPL-GPSLYEIITRNNYNGFHIEDIKLYCI 144 Query: 172 AVIKGLTYLREKHKIMHRDVKPSNILVN--------------------------SRGEIK 205 ++K L YLR K + H D+KP NIL++ S G IK Sbjct: 145 EILKALNYLR-KMSLTHTDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRTKSTG-IK 202 Query: 206 LCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVG 259 L DFG + D S + TR Y +PE + + V SD+WS G L E+ G Sbjct: 203 LIDFGCATFKSDYHG-SIINTRQYRAPEVILNLGWDVSSDMWSFGCVLAELYTG 255 >2WTK-C nrPDB Length = 305 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 46/170 (27%), Positives = 78/170 (45%), Gaps = 14/170 (8%) Query: 105 PAIRNQIIRELQVLHECNSPYIVGFYGAFYSD--GEISICMEHMDGGS---LDQVLKKAG 159 P + +E+Q+L ++ Y++ ++ + ME+ G LD V +K Sbjct: 47 PNGEANVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEK-- 104 Query: 160 RIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL---- 215 R P +I GL YL + I+H+D+KP N+L+ + G +K+ GV+ L Sbjct: 105 RFPVCQAHGYFCQLIDGLEYLHSQ-GIVHKDIKPGNLLLTTGGTLKISALGVAEALHPFA 163 Query: 216 IDSMANSFVGTRSYMSPERLQG--THYSVQSDIWSMGLSLVEMAVGRYPI 263 D + G+ ++ PE G T + DIWS G++L + G YP Sbjct: 164 ADDTCRTSQGSPAFQPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPF 213 >2JD5-A nrPDB Length = 373 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 34/114 (29%), Positives = 57/114 (50%), Gaps = 7/114 (6%) Query: 161 IPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVN------SRGEIKLCDFGVSGQ 214 IP + ++S ++ GL Y+ + I+H D+KP N+L+ + +IK+ D G + Sbjct: 128 IPLIYVKQISKQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNACW 187 Query: 215 LIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDA 268 + NS + TR Y SPE L G + +DIWS + E+ G + P + Sbjct: 188 YDEHYTNS-IQTREYRSPEVLLGAPWGCGADIWSTACLIFELITGDFLFEPDEG 240 >4K33-A nrPDB Length = 325 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 56/184 (30%), Positives = 87/184 (47%), Gaps = 27/184 (14%) Query: 126 IVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIP-------------EQILGK--VS 170 I+ GA G + + +E+ G+L + L+ A R P EQ+ K VS Sbjct: 104 IINLLGACTQGGPLYVLVEYAAKGNLREFLR-ARRPPGLDYSFDTSKPPEEQLTFKDLVS 162 Query: 171 IA--VIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL--IDSMANSFVGT 226 A V +G+ YL + K +HRD+ N+LV +K+ DFG++ + +D + G Sbjct: 163 CAYQVARGMEYLASQ-KCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKETTNGR 221 Query: 227 R--SYMSPERLQGTHYSVQSDIWSMGLSLVEM-AVGRYPIPPPDAKELELMFGCQVEGDA 283 +M+PE L Y+ QSD+WS G+ L E+ +G P P +EL F EG Sbjct: 222 LPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEEL---FKLLKEGHR 278 Query: 284 AETP 287 + P Sbjct: 279 MDKP 282 >3QD2-B nrPDB Length = 332 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 36/102 (35%), Positives = 55/102 (53%), Gaps = 15/102 (14%) Query: 169 VSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFG-VSGQLIDSMANSF---- 223 + I + + + +L K +MHRD+KPSNI +K+ DFG V+ D + Sbjct: 169 IFIQIAEAVEFLHSK-GLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPM 227 Query: 224 ---------VGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEM 256 VGT+ YMSPE++ G +YS + DI+S+GL L E+ Sbjct: 228 PAYATHTGQVGTKLYMSPEQIHGNNYSHKVDIFSLGLILFEL 269 Score = 42.4 bits (98), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 23/67 (34%), Positives = 36/67 (53%) Query: 67 DFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYI 126 DFE I +G G GVVF+ +K A K I L + R +++RE++ L + P I Sbjct: 7 DFEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGI 66 Query: 127 VGFYGAF 133 V ++ A+ Sbjct: 67 VRYFNAW 73 >4CRL-A nrPDB Length = 406 Score = 58.5 bits (140), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 45/165 (27%), Positives = 78/165 (47%), Gaps = 23/165 (13%) Query: 113 RELQVLHECNSPYIVGFYGAFYSDGEISICM-----EH-----MDGGSLDQVLKKAGRIP 162 RE+ +L E P ++ F S + + + EH + + KK ++P Sbjct: 68 REIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLP 127 Query: 163 EQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVN----SRGEIKLCDFGVSGQLIDS 218 ++ + ++ G+ YL + ++HRD+KP+NILV RG +K+ D G + +L +S Sbjct: 128 RGMVKSLLYQILDGIHYL-HANWVLHRDLKPANILVMGEGPERGRVKIADMGFA-RLFNS 185 Query: 219 ------MANSFVGTRSYMSPERLQGT-HYSVQSDIWSMGLSLVEM 256 + V T Y +PE L G HY+ DIW++G E+ Sbjct: 186 PLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAEL 230 >5HIE-A nrPDB Length = 302 Score = 58.5 bits (140), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 60/209 (28%), Positives = 107/209 (51%), Gaps = 17/209 (8%) Query: 62 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHEC 121 E+ D +G+G+ G V+K K G V + L +++ A +N E+ VL + Sbjct: 32 EIPDGQITVGQRIGSGSFGTVYK--GKWHGDVAVKMLTPQQLQ-AFKN----EVGVLRKT 84 Query: 122 NSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQI-LGKVSIAVIKGLTYL 180 I+ F G + + +++I + +G SL L E I L ++ +G+ YL Sbjct: 85 RHVNILLFMG-YSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYL 143 Query: 181 REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSG-QLIDSMANSF---VGTRSYMSPE--R 234 K I+HRD+K +NI ++ +K+ DFG++ + S ++ F G+ +M+PE R Sbjct: 144 HAK-SIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIR 202 Query: 235 LQGTH-YSVQSDIWSMGLSLVEMAVGRYP 262 +Q + YS QSD+++ G+ L E+ G+ P Sbjct: 203 MQDKNPYSFQSDVYAFGIVLYELMTGQLP 231 >5AP3-A nrPDB Length = 313 Score = 58.5 bits (140), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 58/217 (26%), Positives = 102/217 (47%), Gaps = 30/217 (13%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE-----IKPAIRNQI--IRELQVLHE 120 + + ++G+G VF+V ++ + A K ++LE + RN+I + +LQ Sbjct: 30 YSILKQIGSGGSSKVFQVLNEKKQ-IYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQ--- 85 Query: 121 CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL 180 +S I+ Y +D I + ME L+ LKK I +++ + + Sbjct: 86 -HSDKIIRLYDYEITDQYIYMVME-CGNIDLNGWLKKKKSIDPWERKSYWKNMLEAVHTI 143 Query: 181 REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL----IDSMANSFVGTRSYMSPERLQ 236 + H I+H D+KP+N L+ G +KL DFG++ Q+ + +S VGT +YM PE ++ Sbjct: 144 HQ-HGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIK 201 Query: 237 GTHYSVQS-----------DIWSMGLSLVEMAVGRYP 262 S ++ D+WS+G L M G+ P Sbjct: 202 DMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTP 238 >3ZBF-A nrPDB Length = 322 Score = 58.2 bits (139), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 55/211 (26%), Positives = 89/211 (42%), Gaps = 35/211 (16%) Query: 74 LGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAF 133 LG G+G + V G K+ + ++E ++ + N P I+ G Sbjct: 58 LGVGSGEIKVAVKTLKKGSTDQEKI-----------EFLKEAHLMSKFNHPNILKQLGVC 106 Query: 134 YSDGEISICMEHMDGGSLDQVLKKAGRIP-------EQILGKVSIAVIKGLTYLREKHKI 186 + I +E M+GG L L+KA L + + + KG YL H I Sbjct: 107 LLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFI 166 Query: 187 MHRDVKPSNILVNSRGE-----IKLCDFGVSGQLIDSMANSFVGTRS-------YMSPER 234 HRD+ N LV+ + +K+ DFG++ D N + R +M+PE Sbjct: 167 -HRDLAARNCLVSVKDYTSPRIVKIGDFGLAR---DIYKNDYYRKRGEGLLPVRWMAPES 222 Query: 235 LQGTHYSVQSDIWSMGLSLVE-MAVGRYPIP 264 L ++ QSD+WS G+ + E + +G P P Sbjct: 223 LMDGIFTTQSDVWSFGILIWEILTLGHQPYP 253 >3HNG-A nrPDB Length = 360 Score = 57.8 bits (138), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 34/100 (34%), Positives = 57/100 (57%), Gaps = 6/100 (6%) Query: 170 SIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVG-TR- 227 S V +G+ +L + K +HRD+ NIL++ +K+CDFG++ + + G TR Sbjct: 205 SFQVARGMEFLSSR-KCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRKGDTRL 263 Query: 228 --SYMSPERLQGTHYSVQSDIWSMGLSLVEM-AVGRYPIP 264 +M+PE + YS +SD+WS G+ L E+ ++G P P Sbjct: 264 PLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSPYP 303 >2ZMD-A nrPDB Length = 390 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 57/218 (26%), Positives = 101/218 (46%), Gaps = 30/218 (13%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE-----IKPAIRNQI--IRELQVLHE 120 + + ++G+G VF+V ++ + A K ++LE + RN+I + +LQ Sbjct: 58 YSILKQIGSGGSSKVFQVLNEKKQ-IYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQ--- 113 Query: 121 CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL 180 +S I+ Y +D I + ME L+ LKK I +++ + + Sbjct: 114 -HSDKIIRLYDYEITDQYIYMVME-CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTI 171 Query: 181 REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL----IDSMANSFVGTRSYMSPERLQ 236 + H I+H D+KP+N L+ G +KL DFG++ Q+ + +S VG +YM PE ++ Sbjct: 172 HQ-HGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGAVNYMPPEAIK 229 Query: 237 GTHYSVQS-----------DIWSMGLSLVEMAVGRYPI 263 S ++ D+WS+G L M G+ P Sbjct: 230 DMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF 267 >3UIM-A nrPDB Length = 326 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 53/212 (25%), Positives = 101/212 (47%), Gaps = 18/212 (8%) Query: 62 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHEC 121 ++ D+F + LG G G V+K G ++A K + E Q E++++ Sbjct: 26 QVASDNFSNKNILGRGGFGKVYK-GRLADGTLVAVKRLKEERTQGGELQFQTEVEMISMA 84 Query: 122 NSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQ-------ILGKVSIAVI 174 ++ G + E + +M GS+ L++ PE ++++ Sbjct: 85 VHRNLLRLRGFCMTPTERLLVYPYMANGSVASCLRER---PESQPPLDWPKRQRIALGSA 141 Query: 175 KGLTYLREKH--KIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID----SMANSFVGTRS 228 +GL YL + KI+HRDVK +NIL++ E + DFG++ +L+D + + GT Sbjct: 142 RGLAYLHDHCDPKIIHRDVKAANILLDEEFEAVVGDFGLA-KLMDYKDTHVTTAVRGTIG 200 Query: 229 YMSPERLQGTHYSVQSDIWSMGLSLVEMAVGR 260 +++PE L S ++D++ G+ L+E+ G+ Sbjct: 201 HIAPEYLSTGKSSEKTDVFGYGVMLLELITGQ 232 >5U6B-A nrPDB Length = 307 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 54/254 (21%), Positives = 109/254 (42%), Gaps = 33/254 (12%) Query: 40 LELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLI 99 L + E+ +++L + + KV K LG G G V + ++ + Sbjct: 5 LGISEELKEKLRDVMVDRHKVALGK--------TLGEGEFGAVMEGQLNQDDSILKVAVK 56 Query: 100 HLEIKPAIRNQI---IRELQVLHECNSPYIVGFYGAFYSDGEIS------ICMEHMDGGS 150 ++I R+++ + E + E + P ++ G + E + + M G Sbjct: 57 TMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGD 116 Query: 151 LDQVL------KKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEI 204 L L + +P Q+L K + G+ YL K + +HRD+ N ++N + Sbjct: 117 LHSFLLYSRLGDQPVYLPTQMLVKFMADIASGMEYLSTK-RFIHRDLAARNCMLNENMSV 175 Query: 205 KLCDFGVSGQLIDSMANSFVGTR------SYMSPERLQGTHYSVQSDIWSMGLSLVEMAV 258 + DFG+S ++ + + + R +++ E L Y+ +SD+WS G+++ E+A Sbjct: 176 CVADFGLSKKIYN--GDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIAT 233 Query: 259 -GRYPIPPPDAKEL 271 G+ P P + E+ Sbjct: 234 RGQTPYPGVENSEI 247 >4XLV-A nrPDB Length = 328 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 52/211 (24%), Positives = 93/211 (44%), Gaps = 23/211 (10%) Query: 69 EKIS---ELGAGNGGVVFKVSHK-----PSGLVMARKLIHLEIKPAIRNQIIRELQVLHE 120 EKI+ ELG G+ G+V++ + + + +A K ++ R + + E V+ Sbjct: 39 EKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKG 98 Query: 121 CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLK--------KAGRIPEQILGKVSIA 172 ++V G + ME M G L L+ GR P + + +A Sbjct: 99 FTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMA 158 Query: 173 --VIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGT---- 226 + G+ YL K K +HRD+ N +V +K+ DFG++ + ++ G Sbjct: 159 AEIADGMAYLNAK-KFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLP 217 Query: 227 RSYMSPERLQGTHYSVQSDIWSMGLSLVEMA 257 +M+PE L+ ++ SD+WS G+ L E+ Sbjct: 218 VRWMAPESLKDGVFTTSSDMWSFGVVLWEIT 248 >3PG1-A nrPDB Length = 362 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 40/154 (25%), Positives = 73/154 (47%), Gaps = 8/154 (5%) Query: 110 QIIRELQVLHECNSPYIVGFYGAFYSDGE-----ISICMEHMDGGSLDQVLKKAGRIPEQ 164 +++RE+++L+ + P I+G F E + + E M + + I Q Sbjct: 75 RVLREIRLLNHFHHPNILGLRDIFVHFEEPAMHKLYLVTELMRTDLAQVIHDQRIVISPQ 134 Query: 165 ILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQ-LIDSMANSF 223 + ++ GL L E ++HRD+ P NIL+ +I +CDF ++ + D+ + Sbjct: 135 HIQYFMYHILLGLHVLHEA-GVVHRDLHPGNILLADNNDITICDFNLAREDTADANKTHY 193 Query: 224 VGTRSYMSPER-LQGTHYSVQSDIWSMGLSLVEM 256 V R Y +PE +Q ++ D+WS G + EM Sbjct: 194 VTHRWYRAPELVMQFKGFTKLVDMWSAGCVMAEM 227 >3HKO-A nrPDB Length = 345 Score = 55.8 bits (133), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 61/248 (24%), Positives = 96/248 (38%), Gaps = 61/248 (24%) Query: 74 LGAGNGGVVFKVSHKPSGLVMARKLIH----LEIKPAIRNQIIRELQVLHECNSPYIVGF 129 +G G+ GVV + + A K+++ +I P +I E++++ + + P I Sbjct: 34 IGQGSYGVVRVAIENQTRAIRAIKIMNKNKIRQINPKDVERIKTEVRLMKKLHHPNIARL 93 Query: 130 YGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIK-------------- 175 Y + + I + ME GG L L K + GK ++ V+K Sbjct: 94 YEVYEDEQYICLVMELCHGGHL---LDKLNVFIDDSTGKCAMDVVKTQICPCPECNEEAI 150 Query: 176 -----------------------------GLTYLREKHKIMHRDVKPSNIL--VNSRGEI 204 L YL + I HRD+KP N L N EI Sbjct: 151 NGSIHGFRESLDFVQREKLISNIMRQIFSALHYLHNQ-GICHRDIKPENFLFSTNKSFEI 209 Query: 205 KLCDFGVSGQLIDSMANSF------VGTRSYMSPERLQGTH--YSVQSDIWSMGLSLVEM 256 KL DFG+S + + GT +++PE L T+ Y + D WS G+ L + Sbjct: 210 KLVDFGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEVLNTTNESYGPKCDAWSAGVLLHLL 269 Query: 257 AVGRYPIP 264 +G P P Sbjct: 270 LMGAVPFP 277 >3ZZW-A nrPDB Length = 289 Score = 55.5 bits (132), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 48/165 (29%), Positives = 74/165 (44%), Gaps = 33/165 (20%) Query: 145 HMDGGSLD--QVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRG 202 H D GS D + +K A P+ + IA G+ YL H ++H+D+ N+LV + Sbjct: 109 HSDVGSTDDDRTVKSALEPPDFVHLVAQIAA--GMEYL-SSHHVVHKDLATRNVLVYDKL 165 Query: 203 EIKLCDFGVSGQLIDS-----MANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSL---- 253 +K+ D G+ ++ + + NS + R +M+PE + +S+ SDIWS G+ L Sbjct: 166 NVKISDLGLFREVYAADYYKLLGNSLLPIR-WMAPEAIMYGKFSIDSDIWSYGVVLWEVF 224 Query: 254 ---------------VEMAVGRYPIPPPD---AKELELMFGCQVE 280 VEM R +P PD A LM C E Sbjct: 225 SYGLQPYCGYSNQDVVEMIRNRQVLPCPDDCPAWVYALMIECWNE 269 >3MDY-A nrPDB Length = 337 Score = 55.1 bits (131), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 52/209 (24%), Positives = 91/209 (43%), Gaps = 20/209 (9%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIV 127 + + ++G G G V+ + + + E +I + + + HE +I Sbjct: 39 IQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIA 98 Query: 128 GFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLRE----- 182 S ++ + ++ + GSL LK + +L K++ + + GL +L Sbjct: 99 ADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKSML-KLAYSSVSGLCHLHTEIFST 157 Query: 183 --KHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLI------DSMANSFVGTRSYMSP-- 232 K I HRD+K NILV G + D G++ + I D N+ VGT+ YM P Sbjct: 158 QGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPEV 217 Query: 233 --ERLQGTHYS--VQSDIWSMGLSLVEMA 257 E L H+ + +D++S GL L E+A Sbjct: 218 LDESLNRNHFQSYIMADMYSFGLILWEVA 246 >5GRN-A nrPDB Length = 356 Score = 54.7 bits (130), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 51/218 (23%), Positives = 97/218 (44%), Gaps = 35/218 (16%) Query: 80 GVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVL-HECNSPYIVGFYGAFYSDGE 138 G + +S + +A K++ + + + ++ EL+++ H IV GA G Sbjct: 65 GTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGP 124 Query: 139 ISICMEHMDGGSLDQVL----------KKAGRIPEQI----------------LGKVSIA 172 I I E+ G L L KK + ++ L + Sbjct: 125 IYIITEYCFYGDLVNYLHKNRDSFLSHKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQ 184 Query: 173 VIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID-----SMANSFVGTR 227 V +G+ +L K+ + HRD+ N+L+ +K+CDFG++ ++ S ++F+ + Sbjct: 185 VARGMEFLASKNCV-HRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVK 243 Query: 228 SYMSPERLQGTHYSVQSDIWSMGLSLVEM-AVGRYPIP 264 +M+PE + Y+ SD+WS G+ L E+ ++G P P Sbjct: 244 -WMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYP 280 >1PY5-A nrPDB Length = 326 Score = 54.3 bits (129), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 46/155 (29%), Positives = 75/155 (48%), Gaps = 24/155 (15%) Query: 126 IVGFYGAFYSDG----EISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL- 180 I+GF A D ++ + ++ + GSL L + E ++ K++++ GL +L Sbjct: 85 ILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMI-KLALSTASGLAHLH 143 Query: 181 ------REKHKIMHRDVKPSNILVNSRGEIKLCDFGV------SGQLIDSMANSFVGTRS 228 + K I HRD+K NILV G + D G+ + ID N VGT+ Sbjct: 144 MEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKR 203 Query: 229 YMSPERLQGT----HYSV--QSDIWSMGLSLVEMA 257 YM+PE L + H+ ++DI++MGL E+A Sbjct: 204 YMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIA 238 >3M42-A nrPDB Length = 299 Score = 53.9 bits (128), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 71/306 (23%), Positives = 119/306 (38%), Gaps = 66/306 (21%) Query: 66 DDFEKISE-LGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSP 124 DD++ S+ LG G G V ++ +K + A K+ L+ P R ++ + + Sbjct: 17 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKM--LQDCPKARREVELHWRASQCPHIV 74 Query: 125 YIVGFYGAFYSDGE-ISICMEHMDGGSLDQVLKKAG--RIPEQILGKVSIAVIKGLTYLR 181 IV Y Y+ + + I ME +DGG L ++ G E+ ++ ++ + + YL Sbjct: 75 RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 134 Query: 182 EKHKIMHRDVKPSNILVNSR---GEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGT 238 + I HRDVKP N+L S+ +KL DFG + + G Sbjct: 135 SIN-IAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT--------------------GE 173 Query: 239 HYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLS 298 Y D+WS+G+ + + G PP G +S Sbjct: 174 KYDKSCDMWSLGVIMYILLCG--------------------------YPPFYSNHGLAIS 207 Query: 299 SYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVH 358 GM +R M +E P P+ S E + + L P +R + + M H Sbjct: 208 P-GMKTRIRMGQYEF-------PNPEWSE--VSEEVKMLIRNLLKTEPTQRMTITEFMNH 257 Query: 359 AFIKRS 364 +I +S Sbjct: 258 PWIMQS 263 >2I6L-A nrPDB Length = 320 Score = 53.5 bits (127), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 56/224 (25%), Positives = 104/224 (46%), Gaps = 31/224 (13%) Query: 74 LGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFY--- 130 LG G G+VF +A K I L ++++ + RE++++ + IV + Sbjct: 19 LGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKHAL-REIKIIRRLDHDNIVKVFEIL 77 Query: 131 -----------GAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTY 179 G+ + I E+M+ L VL++ G + E+ +++GL Y Sbjct: 78 GPSGSQLTDDVGSLTELNSVYIVQEYMET-DLANVLEQ-GPLLEEHARLFMYQLLRGLKY 135 Query: 180 LREKHKIMHRDVKPSNILVNSRGEI-KLCDFGVSGQLID-------SMANSFVGTRSYMS 231 + + ++HRD+KP+N+ +N+ + K+ DFG++ +++D ++ V T+ Y S Sbjct: 136 IHSAN-VLHRDLKPANLFINTEDLVLKIGDFGLA-RIMDPHYSHKGHLSEGLV-TKWYRS 192 Query: 232 PERLQG-THYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELM 274 P L +Y+ D+W+ G EM G+ A ELE M Sbjct: 193 PRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLF--AGAHELEQM 234 >3RP9-A nrPDB Length = 458 Score = 53.5 bits (127), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 54/227 (23%), Positives = 94/227 (41%), Gaps = 38/227 (16%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIR-NQIIRELQVLHECNSP 124 D +E +G G+ G V + K V+A K I + I +I+RE+ +L+ N Sbjct: 53 DRYEIRHLIGTGSYGHVCEAYDKLEKRVVAIKKILRVFEDLIDCKRILREIAILNRLNHD 112 Query: 125 YIVGFYGAFYSDG-----EISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTY 179 ++V E+ + +E D ++ + + E + + ++ G+ Y Sbjct: 113 HVVKVLDIVIPKDVEKFDELYVVLEIADS-DFKKLFRTPVYLTELHIKTLLYNLLVGVKY 171 Query: 180 LREKHKIMHRDVKPSNILVNSRGEIKLCDFGVS----------GQL-------------- 215 + I+HRD+KP+N LVN +K+CDFG++ QL Sbjct: 172 VHSA-GILHRDLKPANCLVNQDCSVKVCDFGLARTVDYPENGNSQLPISPREDDMNLVTF 230 Query: 216 -----IDSMANSFVGTRSYMSPER-LQGTHYSVQSDIWSMGLSLVEM 256 + V TR Y +PE L +Y+ D+WS+G E+ Sbjct: 231 PHTKNLKRQLTGHVVTRWYRAPELILLQENYTEAIDVWSIGCIFAEL 277 >6BFN-A nrPDB Length = 342 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 45/222 (20%), Positives = 100/222 (45%), Gaps = 21/222 (9%) Query: 67 DFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIK-PAIRNQIIRELQVLHECNSPY 125 +F + ++G G G V++ + + + R + +++ A++ + E++ L P Sbjct: 23 NFSEELKIGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPN 82 Query: 126 IVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRI------PEQILGKVSIAVIKGLTY 179 IV F G +G + + GSL+ L + P+++ + + + + + Sbjct: 83 IVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRL--DILLGTARAIQF 140 Query: 180 LREKH-KIMHRDVKPSNILVNSRGEIKLCDFGV-----------SGQLIDSMANSFVGTR 227 L + ++H D+K SN+L++ R KL DFG+ S + + + GT Sbjct: 141 LHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTL 200 Query: 228 SYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAK 269 +Y+ E ++ +V +D +S G+ ++E G+ + A+ Sbjct: 201 AYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQRAVKTHGAR 242 >5VDK-A nrPDB Length = 297 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 38/147 (25%), Positives = 69/147 (46%), Gaps = 21/147 (14%) Query: 65 DDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRN--QIIRELQVLHEC- 121 + +F ++ ++G G G V+K + G V A IK +++ ++ E LHE Sbjct: 14 EKEFLEVEKIGVGEFGTVYKCIKRLDGCVYA-------IKRSMKTFTELSNENSALHEVY 66 Query: 122 ------NSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVL----KKAGRIPEQILGKVSI 171 + P++V +Y ++ D + I E+ +GGSL + K E L + + Sbjct: 67 AHAVLGHHPHVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILL 126 Query: 172 AVIKGLTYLREKHKIMHRDVKPSNILV 198 + GL Y+ ++H D+KPSNI + Sbjct: 127 QISLGLNYIHNS-SMVHLDIKPSNIFI 152 >5VC6-A nrPDB Length = 289 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 55/225 (24%), Positives = 103/225 (45%), Gaps = 32/225 (14%) Query: 67 DFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQ-IIRELQVLHEC--NS 123 +F ++ ++G+G G VFK + G + A K + ++ Q +RE+ H Sbjct: 12 EFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYA-HAVLGQH 70 Query: 124 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRI----PEQILGKVSIAVIKGLTY 179 ++V ++ A+ D + I E+ +GGSL + + RI E L + + V +GL Y Sbjct: 71 SHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRY 130 Query: 180 LREKHKIMHRDVKPSNILV------NSRGE-------------IKLCDFGVSGQLIDSMA 220 + ++H D+KPSNI + N+ E K+ D G ++ Sbjct: 131 IHSM-SLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQV 189 Query: 221 NSFVGTRSYMSPERLQGTHYSV-QSDIWSMGLSLVEMAVGRYPIP 264 G +++ E LQ + + ++DI+++ L++V A G P+P Sbjct: 190 EE--GDSRFLANEVLQENYTHLPKADIFALALTVV-CAAGAEPLP 231 >3SOC-A nrPDB Length = 322 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 42/140 (30%), Positives = 69/140 (49%), Gaps = 19/140 (13%) Query: 136 DGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREK-------HK--I 186 D ++ + + GSL LK A + L ++ + +GL YL E HK I Sbjct: 94 DVDLWLITAFHEKGSLSDFLK-ANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAI 152 Query: 187 MHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA----NSFVGTRSYMSPERLQGT---- 238 HRD+K N+L+ + + DFG++ + + + VGTR YM+PE L+G Sbjct: 153 SHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQ 212 Query: 239 -HYSVQSDIWSMGLSLVEMA 257 ++ D+++MGL L E+A Sbjct: 213 RDAFLRIDMYAMGLVLWELA 232 >3Q4U-A nrPDB Length = 301 Score = 52.4 bits (124), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 55/212 (25%), Positives = 92/212 (43%), Gaps = 24/212 (11%) Query: 67 DFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIR-NQIIRELQVLHECNSPY 125 D + +G G G V++ S + V + + K R ++ + + HE + Sbjct: 9 DITLLECVGKGRYGEVWRGSWQGEN-VAVKIFSSRDEKSWFRETELYNTVMLRHENILGF 67 Query: 126 IVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL----- 180 I + +S ++ + + + GSL L+ L ++ +++ GL +L Sbjct: 68 IASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCL-RIVLSIASGLAHLHIEIF 126 Query: 181 --REKHKIMHRDVKPSNILVNSRGEIKLCDFGV------SGQLIDSMANSFVGTRSYMSP 232 + K I HRD+K NILV G+ + D G+ S +D N VGT+ YM+P Sbjct: 127 GTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAP 186 Query: 233 ERLQGT-------HYSVQSDIWSMGLSLVEMA 257 E L T Y + DIW+ GL L E+A Sbjct: 187 EVLDETIQVDCFDSYK-RVDIWAFGLVLWEVA 217 >2QLU-A nrPDB Length = 314 Score = 51.6 bits (122), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 45/138 (32%), Positives = 65/138 (47%), Gaps = 20/138 (14%) Query: 138 EISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREK--------HK--IM 187 E+ + D GSL LK I L V+ + +GL+YL E HK I Sbjct: 87 ELWLITAFHDKGSLTDYLK-GNIITWNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIA 145 Query: 188 HRDVKPSNILVNSRGEIKLCDFGVSGQLIDSM----ANSFVGTRSYMSPERLQGT----- 238 HRD K N+L+ S L DFG++ + + VGTR YM+PE L+G Sbjct: 146 HRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVGTRRYMAPEVLEGAINFQR 205 Query: 239 HYSVQSDIWSMGLSLVEM 256 ++ D+++MGL L E+ Sbjct: 206 DAFLRIDMYAMGLVLWEL 223 >3AOX-A nrPDB Length = 344 Score = 51.2 bits (121), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 60/243 (24%), Positives = 100/243 (41%), Gaps = 24/243 (9%) Query: 52 AFLTQKQKVGELKD---DDFEKISELGAGNGGVVFK-----VSHKPSGLVMARKLIHLEI 103 F + + +LK+ + I LG G G V++ + + PS L +A K + Sbjct: 30 CFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVC 89 Query: 104 KPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPE 163 + E ++ + N IV G I +E M GG L L++ P Sbjct: 90 SEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPS 149 Query: 164 Q-----ILGKVSIA--VIKGLTYLREKHKIMHRDVKPSNILVNSRGE---IKLCDFGVSG 213 Q +L + +A + G YL E H I HRD+ N L+ G K+ DFG++ Sbjct: 150 QPSSLAMLDLLHVARDIACGCQYLEENHFI-HRDIAARNCLLTCPGPGRVAKIGDFGMAR 208 Query: 214 QLIDSMANSFVGTR----SYMSPERLQGTHYSVQSDIWSMGLSLVEM-AVGRYPIPPPDA 268 + + G +M PE ++ ++D WS G+ L E+ ++G P P Sbjct: 209 DIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSN 268 Query: 269 KEL 271 +E+ Sbjct: 269 QEV 271 >3G2F-A nrPDB Length = 336 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 61/223 (27%), Positives = 102/223 (45%), Gaps = 39/223 (17%) Query: 66 DDFEKISELGAGNGGVVFK--VSHKPSGLVMARKLIHLEIKPAIRNQ--IIRELQVLHEC 121 D+ + + +G G G V+K + +P +A K+ + N+ I R + H+ Sbjct: 13 DNLKLLELIGRGRYGAVYKGSLDERP----VAVKVFSFANRQNFINEKNIYRVPLMEHDN 68 Query: 122 NSPYIVGFYGAFYSDG--EISICMEHMDGGSLDQVLKKAGRIPEQILG-KVSIAVIKGLT 178 + +IVG +DG E + ME+ GSL + L + + + +++ +V +GL Sbjct: 69 IARFIVGD-ERVTADGRMEYLLVMEYYPNGSLCKYL--SLHTSDWVSSCRLAHSVTRGLA 125 Query: 179 YLRE--------KHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLI----------DSMA 220 YL K I HRD+ N+LV + G + DFG+S +L D+ A Sbjct: 126 YLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPGEEDNAA 185 Query: 221 NSFVGTRSYMSPERLQGT-------HYSVQSDIWSMGLSLVEM 256 S VGT YM+PE L+G Q D++++GL E+ Sbjct: 186 ISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEI 228 >5WNO-A nrPDB Length = 330 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 49/202 (24%), Positives = 94/202 (46%), Gaps = 29/202 (14%) Query: 73 ELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIR---------NQIIRELQVLHECNS 123 +LGAG G VF +G+ ++ +++I AI+ ++++ E + Sbjct: 29 KLGAGAFGTVF------AGIYYPKRAKNVKIPVAIKVFQTDQSQTDEMLEEATNMFRLRH 82 Query: 124 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR---IPEQILGKVSIAVIKGLTYL 180 ++ G D + I + G+L LK EQ+L IA G+ YL Sbjct: 83 DNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKENLGAREQVLYCYQIA--SGMQYL 140 Query: 181 REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRS------YMSPER 234 EK +++HRD+ N+LV +++ DFG+S +++ A+S + +S +++ E Sbjct: 141 -EKQRVVHRDLATRNVLVKKFNHVEITDFGLS-KILKHDADS-ITIKSGKVAIKWLAIEI 197 Query: 235 LQGTHYSVQSDIWSMGLSLVEM 256 Y+ SD+W+ G++ E+ Sbjct: 198 FSKHCYTHASDVWAFGVTCWEI 219 >3MY0-A nrPDB Length = 305 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 40/142 (28%), Positives = 65/142 (45%), Gaps = 20/142 (14%) Query: 135 SDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL-------REKHKIM 187 S ++ + + + GSL L++ P L +++++ GL +L + K I Sbjct: 77 SSTQLWLITHYHEHGSLYDFLQRQTLEPHLAL-RLAVSAACGLAHLHVEIFGTQGKPAIA 135 Query: 188 HRDVKPSNILVNSRGEIKLCDFGVS------GQLIDSMANSFVGTRSYMSPE------RL 235 HRD K N+LV S + + D G++ +D N VGT+ YM+PE R Sbjct: 136 HRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLDEQIRT 195 Query: 236 QGTHYSVQSDIWSMGLSLVEMA 257 +DIW+ GL L E+A Sbjct: 196 DCFESYKWTDIWAFGLVLWEIA 217 >1TKI-A nrPDB Length = 321 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 46/183 (25%), Positives = 85/183 (46%), Gaps = 9/183 (4%) Query: 73 ELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGA 132 +LG G G+V + S K + ++K + + +E+ +L+ I+ + + Sbjct: 12 DLGRGEFGIVHRCVETSSKKTYMAKFV--KVKGTDQVLVKKEISILNIARHRNILHLHES 69 Query: 133 FYSDGEISICMEHMDGGSL-DQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDV 191 F S E+ + E + G + +++ A + E+ + V + L +L H I H D+ Sbjct: 70 FESMEELVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCEALQFL-HSHNIGHFDI 128 Query: 192 KPSNILVNSR--GEIKLCDFGVSGQLI--DSMANSFVGTRSYMSPERLQGTHYSVQSDIW 247 +P NI+ +R IK+ +FG + QL D+ F Y +PE Q S +D+W Sbjct: 129 RPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLFTAP-EYYAPEVHQHDVVSTATDMW 187 Query: 248 SMG 250 S+G Sbjct: 188 SLG 190 >5IKW-A nrPDB Length = 310 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 58/220 (26%), Positives = 94/220 (42%), Gaps = 40/220 (18%) Query: 74 LGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNS-PYIVGFYGA 132 L G VF V G+ A K +++ P + N RE+ ++ E + IVG+ Sbjct: 22 LAEGGFSTVFLV-RTHGGIRCALKRMYVNNMPDL-NVCKREITIMKELSGHKNIVGYLDC 79 Query: 133 FYSD-----GEISICMEHMDGGSL-DQVLKK--AGRIPEQILGKVSIAVIKGLTYLRE-K 183 + E+ I ME+ G + +Q+ KK G ++L ++ + + L + K Sbjct: 80 AVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVL-QIFCDTCEAVARLHQCK 138 Query: 184 HKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVG-----------------T 226 I+HRD+K NIL+N G LCDFG S N F+ T Sbjct: 139 TPIIHRDLKVENILLNDGGNYVLCDFG-------SATNKFLNPQKDGVNVVEEEIKKYTT 191 Query: 227 RSYMSPERLQ---GTHYSVQSDIWSMGLSLVEMAVGRYPI 263 SY +PE + G + ++DIW++G L ++ P Sbjct: 192 LSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPF 231 >5L2Q-C nrPDB Length = 320 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 35/126 (27%), Positives = 67/126 (53%), Gaps = 5/126 (3%) Query: 150 SLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGE-IKLCD 208 +L + K R+ E+ + V++ + L +K+ I+HRD+K N+++N R I + + Sbjct: 139 NLQHYVIKEKRLSERETVVIFYDVVRVVEALHQKN-IVHRDLKLGNMVLNKRTHRITITN 197 Query: 209 FGVSGQLID--SMANSFVGTRSYMSPERLQGTHYSVQ-SDIWSMGLSLVEMAVGRYPIPP 265 F + L+ + G+ +Y+SP+ L G Y + SD+W++G+ L M G++P Sbjct: 198 FCLGKHLVSEGDLLKDQRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPFYD 257 Query: 266 PDAKEL 271 +EL Sbjct: 258 SIPQEL 263 >5TE0-A nrPDB Length = 347 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 43/175 (24%), Positives = 80/175 (45%), Gaps = 25/175 (14%) Query: 113 RELQVLHECNS-PYIVGFYGAFYSD------GEISICMEHMDGGSLDQVLKK---AGRIP 162 RE+Q++ + + IVG+ + ++ E+ I M+ GG + ++ + G Sbjct: 64 REIQIMRDLSGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTE 123 Query: 163 EQILGKVSIAVIKGLTYLRE-KHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMAN 221 ++L ++ + + L + K I+HRD+K NIL++ RG LCDFG + + Sbjct: 124 NEVL-QIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQT 182 Query: 222 SFVG----------TRSYMSPERLQ---GTHYSVQSDIWSMGLSLVEMAVGRYPI 263 V T SY +PE + G + ++DIW++G L ++ P Sbjct: 183 EGVNAVEDEIKKYTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPF 237 >4C59-A nrPDB Length = 340 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 63/261 (24%), Positives = 111/261 (42%), Gaps = 48/261 (18%) Query: 53 FLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQII 112 F+ Q ++GEL+ L G V++ SG A K + L + II Sbjct: 17 FVGQTVELGELR---LRVRRVLAEGGFAFVYEAQDVGSGREYALKRL-LSNEEEKNRAII 72 Query: 113 RELQVLHECNS-PYIVGFYGAFYSDGEIS-------ICMEHMDGGSLDQVLKKA---GRI 161 +E+ + + + P IV F A E S + + + G L + LKK G + Sbjct: 73 QEVCFMKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGPL 132 Query: 162 PEQILGKVSIAVIKGLTYL-REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA 220 + K+ + + ++ R+K I+HRD+K N+L++++G IKLCDFG + + Sbjct: 133 SCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPD 192 Query: 221 NSFVGTRS--------------YMSPERLQ-GTHYSV--QSDIWSMGLSL---------- 253 S+ R Y +PE + +++ + + DIW++G L Sbjct: 193 YSWSAQRRALVEEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPF 252 Query: 254 -----VEMAVGRYPIPPPDAK 269 + + G+Y IPP D + Sbjct: 253 EDGAKLRIVNGKYSIPPHDTQ 273 >2X7G-A nrPDB Length = 389 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 62/268 (23%), Positives = 100/268 (37%), Gaps = 65/268 (24%) Query: 59 KVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVL 118 K+G+L + + I +LG G+ V+ +A K++ + + E+++L Sbjct: 24 KIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVV--KSAQHYTETALDEIKLL 81 Query: 119 HEC---------NSPYIVGFYGAFYSDGE--ISICM--EHMDGGSLDQVLKKAGR-IPEQ 164 +C N +V F G I +CM E + L ++K + +P + Sbjct: 82 -KCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVR 140 Query: 165 ILGKVSIAVIKGLTYLREKHKIMHRDVKPSNI---------------------------- 196 + + V++GL YL K KI+H D+KP NI Sbjct: 141 CVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPS 200 Query: 197 ------------LVN-------SRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQG 237 LVN + +K+ D G + + + TR Y S E L G Sbjct: 201 GSAVSTAPAADLLVNPLDPRNADKIRVKIADLG-NACWVHKHFTEDIQTRQYRSIEVLIG 259 Query: 238 THYSVQSDIWSMGLSLVEMAVGRYPIPP 265 YS +DIWS E+A G Y P Sbjct: 260 AGYSTPADIWSTACMAFELATGDYLFEP 287 >4WUA-A nrPDB Length = 401 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 57/277 (20%), Positives = 106/277 (38%), Gaps = 71/277 (25%) Query: 59 KVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQI---IREL 115 K+G+L + + I +LG G+ V+ S + +K + +++ + + + E+ Sbjct: 34 KIGDLFNGRYHVIRKLGWGHFSTVWL-----SWDIQGKKFVAMKVVKSAEHYTETALDEI 88 Query: 116 QVL--------HECNSPYIVGFYGAFYSDG----EISICMEHMDGGSLDQVLKKAGR-IP 162 ++L ++ N +V F G I + E + L ++K + +P Sbjct: 89 RLLKSVRNSDPNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLP 148 Query: 163 EQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVN----------------------- 199 + K+ V++GL YL K +I+H D+KP NIL++ Sbjct: 149 LPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPP 208 Query: 200 --------------------------SRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPE 233 + ++K+ D G + + + TR Y S E Sbjct: 209 PSGSAVSTAPATAGNFLVNPLEPKNAEKLKVKIADLG-NACWVHKHFTEDIQTRQYRSLE 267 Query: 234 RLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKE 270 L G+ Y+ +DIWS E+A G Y P +E Sbjct: 268 VLIGSGYNTPADIWSTACMAFELATGDYLFEPHSGEE 304 >4LFI-A nrPDB Length = 374 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 50/182 (27%), Positives = 79/182 (43%), Gaps = 15/182 (8%) Query: 186 IMHRDVKPSNILVNSRG-EIKLCDFGVSGQL-IDSMANSFVGTRSYMSPERLQGTH-YSV 242 IMHRDVKP N++++ + +++L D+G++ ++ N V +R + PE L Y Sbjct: 193 IMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDY 252 Query: 243 QSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDA-AETPPRPRTPGRPLSSYG 301 D+WS G L M R P + +L+ +V G + E P Y Sbjct: 253 SLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYD 312 Query: 302 MDS--RPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHA 359 MD R P F +N+ L SG + E D ++ L + ER K+ M H Sbjct: 313 MDQYIRKPWHRF------INDGNKHL-SG--NDEIIDLIDNLLRYDHQERLTAKEAMGHP 363 Query: 360 FI 361 + Sbjct: 364 WF 365 >6O6Q-A nrPDB Length = 335 Score = 48.9 bits (115), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 69/309 (22%), Positives = 123/309 (39%), Gaps = 35/309 (11%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMAR--KLIHLEIKPAIRNQIIRELQVLHE-CN 122 +++E + +LG G VF G+ + + K++ +KP R +I RE+ +L + Sbjct: 41 ENYEILRKLGRGKYSEVF------LGIDLEKREKVVIKVLKPVKRKKIKREISILKNLVD 94 Query: 123 SPYIVGFYGAFYSDGEIS--ICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL 180 P I+ + + EH++ + P + + + L L Sbjct: 95 GPNIIAMLDVVREPQSKTPGLIFEHINNIDFRSLY------PTFTDYDIRFYMYELLKAL 148 Query: 181 REKHK--IMHRDVKPSNILVN-SRGEIKLCDFGVSGQLI-DSMANSFVGTRSYMSPERLQ 236 H IMHRDVKP N++++ + ++L D+G++ + N V +R + PE L Sbjct: 149 DYSHSMGIMHRDVKPHNVMIDHDKKLLRLIDWGLAEYYHPGTEYNVRVASRYFKGPELLV 208 Query: 237 GTH-YSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPR---T 292 Y D+WS G L M + P + +L+ +V G + + Sbjct: 209 DYRLYDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQLVQIVRVLGSKNFKKYLEKYNIS 268 Query: 293 PGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADL 352 G G ++ F +NE L S EF D +++ L + ER Sbjct: 269 LGEEYEDIGYYNKRQWVRF------MNENNKDLVSQ----EFLDLIDRLLRYDHQERLTA 318 Query: 353 KQLMVHAFI 361 K+ M HA+ Sbjct: 319 KEAMKHAYF 327 >4JRN-A nrPDB Length = 372 Score = 48.9 bits (115), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 27/86 (31%), Positives = 42/86 (48%), Gaps = 5/86 (5%) Query: 182 EKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPER---LQGT 238 + I+H D+KP+N L+ G + L DFG I++ +GT Y PER G Sbjct: 219 QAQGIVHTDIKPANFLLLKDGRLFLGDFGT--YRINNSVGRAIGTPGYEPPERPFQATGI 276 Query: 239 HYSVQSDIWSMGLSLVEMAVGRYPIP 264 Y+ +D W +G++L + P P Sbjct: 277 TYTFPTDAWQLGITLYCIWCKERPTP 302 >3QUP-A nrPDB Length = 323 Score = 48.9 bits (115), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 67/275 (24%), Positives = 120/275 (43%), Gaps = 37/275 (13%) Query: 37 LEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKP---SGLV 93 L+ L + ++ +++LE L +Q+ F LG G G V + K S + Sbjct: 2 LDSLGISDELKEKLEDVLIPEQQ--------FTLGRMLGKGEFGSVREAQLKQEDGSFVK 53 Query: 94 MARKLIHLEIKPAIR-NQIIRELQVLHECNSPYIVGFYGAFY---SDGEISICME---HM 146 +A K++ +I + + +RE + E + P++ G + G + I M M Sbjct: 54 VAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFM 113 Query: 147 DGGSLDQVLKKAGRI-------PEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVN 199 G L L A RI P Q L + + + G+ YL ++ I HRD+ N ++ Sbjct: 114 KHGDLHAFLL-ASRIGENPFNLPLQTLVRFMVDIACGMEYLSSRNFI-HRDLAARNCMLA 171 Query: 200 SRGEIKLCDFGVSGQLIDSMANSFVGTRS-----YMSPERLQGTHYSVQSDIWSMGLSLV 254 + + DFG+S + I S G S +++ E L Y+V SD+W+ G+++ Sbjct: 172 EDMTVCVADFGLSRK-IYSGDYYRQGCASKLPVKWLALESLADNLYTVHSDVWAFGVTMW 230 Query: 255 E-MAVGRYPIPPPDAKELELMFGCQVEGDAAETPP 288 E M G+ P + E+ + + G+ + PP Sbjct: 231 EIMTRGQTPYAGIENAEI---YNYLIGGNRLKQPP 262 >6HMD-A nrPDB Length = 365 Score = 48.9 bits (115), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 35/108 (32%), Positives = 53/108 (49%), Gaps = 9/108 (8%) Query: 164 QILGKVSI-----AVIKGLTYLREKHKIMHRDVKPSNILVN-SRGEIKLCDFGVSGQLID 217 QIL I ++K L Y K IMHRDVKP N++++ + +++L D+G++ Sbjct: 142 QILTDFDIRFYMYELLKALDYCHSK-GIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHP 200 Query: 218 SM-ANSFVGTRSYMSPERLQGTH-YSVQSDIWSMGLSLVEMAVGRYPI 263 + N V +R + PE L Y D+WS+G L M R P Sbjct: 201 AQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPF 248 >5XVU-A nrPDB Length = 332 Score = 48.5 bits (114), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 34/98 (34%), Positives = 48/98 (48%), Gaps = 12/98 (12%) Query: 173 VIKGLTYLREKHKIMHRDVKPSNILVNSRG-EIKLCDFGVS-----GQLIDSMANSFVGT 226 ++K L Y + IMHRDVKP NI+++ +I+L +G++ GQ N V + Sbjct: 134 ILKALDYCHSQ-GIMHRDVKPHNIMIDHENRQIRLISWGLAEFYHPGQ----EYNVRVAS 188 Query: 227 RSYMSPERLQGTH-YSVQSDIWSMGLSLVEMAVGRYPI 263 R Y PE L Y DIWS+G L M + P Sbjct: 189 RYYKGPELLIDLQLYDYSLDIWSLGCMLAGMIFKKEPF 226 >5X18-A nrPDB Length = 295 Score = 48.1 bits (113), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 53/207 (25%), Positives = 98/207 (47%), Gaps = 23/207 (11%) Query: 73 ELGAGNGGVVFKVSHKPSGLVMARKLIHLEIK-PAIRNQIIRELQVLHEC-NSPYIVGFY 130 ++G G+ GV+F+ ++ +G+ +A K + + P +R++ + ++L+ N PY +Y Sbjct: 14 KIGEGSFGVLFEGTNMINGVPVAIKFEPRKTEAPQLRDEY-KTYKILNGTPNIPY--AYY 70 Query: 131 GAFYSDGEISICMEHMDGGSLDQVLKKAGR-IPEQILGKVSIAVIKGLTYLREKHKIMHR 189 F +G +I + + G SL+ + GR + + +V++ +I + L H +++R Sbjct: 71 --FGQEGLHNILVIDLLGPSLEDLFDWCGRKFSVKTVVQVAVQMITLIEDL-HAHDLIYR 127 Query: 190 DVKPSNILVNSRGE-----IKLCDFGVSGQLIDSMA---------NSFVGTRSYMSPERL 235 D+KP N L+ G+ I L DFG++ Q D S GT YMS Sbjct: 128 DIKPDNFLIGRPGQPDANNIHLIDFGMAKQYRDPKTKQHIPYREKKSLSGTARYMSINTH 187 Query: 236 QGTHYSVQSDIWSMGLSLVEMAVGRYP 262 G S + D+ ++G G P Sbjct: 188 LGREQSRRDDMEALGHVFFYFLRGHLP 214 >4L68-A nrPDB Length = 340 Score = 47.8 bits (112), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 47/214 (21%), Positives = 99/214 (46%), Gaps = 14/214 (6%) Query: 57 KQKVGEL--KDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRE 114 K K+G+L ++F + + + G +K + P G +A K HL + E Sbjct: 29 KVKLGDLMAATNNFNSENIIVSTRTGTTYK-ALLPDGSALAVK--HLSTCKLGEREFRYE 85 Query: 115 LQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVL-KKAGRIPEQILGKVSIAV 173 + L E + G + E + ++M G+L +L G + ++ + Sbjct: 86 MNQLWELRHSNLAPLLGFCVVEEEKFLVYKYMSNGTLHSLLDSNRGELDWSTRFRIGLGA 145 Query: 174 IKGLTYLREKHK--IMHRDVKPSNILVNSRGEIKLCDFGVSGQLI--DSMANSF----VG 225 +GL +L + I+H+++ S IL++ + ++ D G++ ++ D+ +SF +G Sbjct: 146 ARGLAWLHHGCRPPILHQNICSSVILIDEDFDARIIDSGLARLMVPSDNNESSFMTGDLG 205 Query: 226 TRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVG 259 Y++PE S++ D++ +G+ L+E+A G Sbjct: 206 EFGYVAPEYSTTMLASLKGDVYGLGVVLLELATG 239 >5U6C-A nrPDB Length = 315 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 30/116 (25%), Positives = 57/116 (49%), Gaps = 6/116 (5%) Query: 161 IPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLI--DS 218 IP Q L K + + G+ YL ++ +HRD+ N ++ + + DFG+S ++ D Sbjct: 146 IPLQTLLKFMVDIALGMEYLSNRN-FLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDY 204 Query: 219 MANSFVGTR--SYMSPERLQGTHYSVQSDIWSMGLSLVEMAV-GRYPIPPPDAKEL 271 + +++ E L Y+ +SD+W+ G+++ E+A G P P E+ Sbjct: 205 YRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEM 260 >4BTK-A nrPDB Length = 337 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 37/123 (30%), Positives = 55/123 (44%), Gaps = 21/123 (17%) Query: 160 RIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNI----LVNSRGEIKLCDFGVSGQL 215 R+ +QIL SI I + +L HRD+KPSN L ++ + + DFG++ Q Sbjct: 157 RLGKQILE--SIEAIHSVGFL-------HRDIKPSNFAMGRLPSTYRKCYMLDFGLARQY 207 Query: 216 IDSMAN--------SFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPD 267 ++ + F GT Y S + D+WS+ LVE AVG+ P Sbjct: 208 TNTTGDVRPPRNVAGFRGTVRYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIK 267 Query: 268 AKE 270 KE Sbjct: 268 DKE 270 >4NFN-A nrPDB Length = 309 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 37/123 (30%), Positives = 55/123 (44%), Gaps = 21/123 (17%) Query: 160 RIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNI----LVNSRGEIKLCDFGVSGQL 215 R+ +QIL SI I + +L HRD+KPSN L ++ + + DFG++ Q Sbjct: 122 RLGKQILE--SIEAIHSVGFL-------HRDIKPSNFAMGRLPSTYRKCYMLDFGLARQY 172 Query: 216 IDSMAN--------SFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPD 267 ++ + F GT Y S + D+WS+ LVE AVG+ P Sbjct: 173 TNTTGDVRPPRNVAGFRGTVRYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIK 232 Query: 268 AKE 270 KE Sbjct: 233 DKE 235 >3RAW-A nrPDB Length = 381 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 81/363 (22%), Positives = 139/363 (38%), Gaps = 77/363 (21%) Query: 59 KVGELKDDDFEKISELGAGN-GGVVFKVSHKPSGLVMARKLIHL--EIKPAIRNQI--IR 113 ++G+ + +E + LG G G VV + H +A K+I + + A R +I ++ Sbjct: 44 RIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLK 103 Query: 114 ELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQI--LGKVSI 171 +++ + N V F G + I E + G + + LK+ P + + ++ Sbjct: 104 KIKEKDKENKFLCVLMSDWFNFHGHMCIAFE-LLGKNTFEFLKENNFQPYPLPHVRHMAY 162 Query: 172 AVIKGLTYLREKHKIMHRDVKPSNIL-VNSRGE------------------IKLCDFGVS 212 + L +L E ++ H D+KP NIL VNS E I++ DFG S Sbjct: 163 QLCHALRFLHEN-QLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFG-S 220 Query: 213 GQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELE 272 + V TR Y PE + ++ D+WS+G L E G + +E Sbjct: 221 ATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHL 280 Query: 273 LMF-----------------------GCQVEGDAAETPPRPRTPGRPLSSYGM-DSRPPM 308 +M G V + + + +PL SY + DS + Sbjct: 281 VMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHV 340 Query: 309 AIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEE 368 +F+L+ + LEF +PA+R L + ++H F EE Sbjct: 341 QLFDLMRRM--------------LEF----------DPAQRITLAEALLHPFFAGLTPEE 376 Query: 369 VDF 371 F Sbjct: 377 RSF 379 >6EII-A nrPDB Length = 352 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 34/131 (25%), Positives = 60/131 (45%), Gaps = 15/131 (11%) Query: 140 SICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVN 199 ++ EH++ Q+ + + + + ++K L Y IMHRDVKP N++++ Sbjct: 133 ALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYCHSM-GIMHRDVKPHNVMID 188 Query: 200 SRG-EIKLCDFGVS-----GQLIDSMANSFVGTRSYMSPERLQGTH-YSVQSDIWSMGLS 252 +++L D+G++ GQ N V +R + PE L Y D+WS+G Sbjct: 189 HEHRKLRLIDWGLAEFYHPGQ----EYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCM 244 Query: 253 LVEMAVGRYPI 263 L M + P Sbjct: 245 LASMIFRKEPF 255 >4MD7-E nrPDB Length = 391 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 34/131 (25%), Positives = 60/131 (45%), Gaps = 15/131 (11%) Query: 140 SICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVN 199 ++ EH++ Q+ + + + + ++K L Y IMHRDVKP N++++ Sbjct: 110 ALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYCHSM-GIMHRDVKPHNVMID 165 Query: 200 SRG-EIKLCDFGVS-----GQLIDSMANSFVGTRSYMSPERLQGTH-YSVQSDIWSMGLS 252 +++L D+G++ GQ N V +R + PE L Y D+WS+G Sbjct: 166 HEHRKLRLIDWGLAEFYHPGQ----EYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCM 221 Query: 253 LVEMAVGRYPI 263 L M + P Sbjct: 222 LASMIFRKEPF 232 >2PVN-A nrPDB Length = 352 Score = 45.4 bits (106), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 53/205 (25%), Positives = 86/205 (41%), Gaps = 22/205 (10%) Query: 173 VIKGLTYLREKHKIMHRDVKPSNILVNSR-GEIKLCDFGVSGQLI-DSMANSFVGTRSYM 230 ++K L Y + IMHRDVKP N++++ +++L D+G++ N V +R + Sbjct: 155 LLKALDYCHSQ-GIMHRDVKPHNVMIDHELRKLRLIDWGLAEFYHPGKEYNVRVASRYFK 213 Query: 231 SPE---RLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEG----DA 283 PE LQ YS+ D+WS+G M + P +L+ +V G +A Sbjct: 214 GPELLVDLQDYDYSL--DMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKIAKVLGTDGLNA 271 Query: 284 AETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLI 343 R + + G SR P F D + S E DF++K L Sbjct: 272 YLNKYRIELDPQLEALVGRHSRKPWLKFMNAD----------NQHLVSPEAIDFLDKLLR 321 Query: 344 KNPAERADLKQLMVHAFIKRSDAEE 368 + ER + M H + ++ A E Sbjct: 322 YDHQERLTALEAMTHPYFQQVRAAE 346 >2CMW-A nrPDB Length = 310 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 35/134 (26%), Positives = 58/134 (43%), Gaps = 17/134 (12%) Query: 169 VSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGE-----IKLCDFGVSGQLIDSMA--- 220 ++I ++ + Y+ K+ +++RDVKP N L+ +G I + DFG++ + ID Sbjct: 102 IAIQLLSRMEYVHSKN-LIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKH 160 Query: 221 ------NSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELM 274 S GT YMS G S + D+ ++G + G P A L+ Sbjct: 161 IPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKER 220 Query: 275 FGCQVEGDAAETPP 288 + Q GD P Sbjct: 221 Y--QKIGDTKRNTP 232 >4L00-A nrPDB Length = 304 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 47/188 (25%), Positives = 85/188 (45%), Gaps = 22/188 (11%) Query: 117 VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVL-KKAGRIPEQILGKVSIAVIK 175 ++ + + +IV YG D E + E ++GG LD + +K+ + KV+ + Sbjct: 85 MMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLAS 144 Query: 176 GLTYLREKHKIMHRDVKPSNILVNSRG-------EIKLCDFGVSGQLIDSMANSFVGTRS 228 L+YL +K ++H +V N+L+ G IKL D G+ ++ + Sbjct: 145 ALSYLEDK-DLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSR--QECIERIP 201 Query: 229 YMSPERLQGT-HYSVQSDIWSMGLSLVEMAV-GRYPIPPPDAKELELMFGCQVEGDAAET 286 +++PE ++ + + SV +D WS G +L E+ G P+ E E + E+ Sbjct: 202 WIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFY---------ES 252 Query: 287 PPRPRTPG 294 RP TP Sbjct: 253 RCRPVTPS 260 >4F9B-A nrPDB Length = 361 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 64/286 (22%), Positives = 108/286 (37%), Gaps = 59/286 (20%) Query: 126 IVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHK 185 ++G F + + I M +++ S +L + Q + + + + K L + + Sbjct: 82 VMGVKYCFRKNDHVVIAMPYLEHESFLDILNS---LSFQEVREYMLNLFKALKRIHQ-FG 137 Query: 186 IMHRDVKPSNILVNSR-GEIKLCDFGVSGQLIDSMAN--SFV------------------ 224 I+HRDVKPSN L N R + L DFG++ D+ FV Sbjct: 138 IVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNKCSICL 197 Query: 225 ----------GTRSYMSPERLQGT-HYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELEL 273 GT + +PE L + + D+WS G+ + + GRYP L Sbjct: 198 SRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDDLTAL 257 Query: 274 MFGCQVEGDAAETPPRPRTPGRPLSS----------------YGMDSRPPMAIFELLDYI 317 + G + ET +T G+ + GMDS P ++ + Sbjct: 258 AQIMTIRG-SRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSSTPKLTSDIQGHA 316 Query: 318 VN-EPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIK 362 N E ++P + L + L NPA R ++ ++H F K Sbjct: 317 TNLEGWNEVPDEAYDLLDKL-----LDLNPASRITAEEALLHPFFK 357 >2RIO-A nrPDB Length = 434 Score = 43.5 bits (101), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 65/245 (26%), Positives = 114/245 (46%), Gaps = 48/245 (19%) Query: 69 EKISELGAGNGG-VVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNS-PYI 126 EKI LG G+ G VVF+ S + + + R LI + + E+++L E + P + Sbjct: 20 EKI--LGYGSSGTVVFQGSFQGRPVAVKRMLIDFC------DIALMEIKLLTESDDHPNV 71 Query: 127 VGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGK----VSI--AVIKGLTYL 180 + +Y + +D + I +E + D V K L K +S+ + G+ +L Sbjct: 72 IRYYCSETTDRFLYIALELCNLNLQDLVESKNVSDENLKLQKEYNPISLLRQIASGVAHL 131 Query: 181 REKHKIMHRDVKPSNILVNSRG-------------EIKLCDFGVSGQLIDSMANSF---- 223 KI+HRD+KP NILV++ I + DFG+ +L DS +SF Sbjct: 132 HSL-KIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKL-DSGQSSFRTNL 189 Query: 224 ---VGTRSYMSPERLQGTHYSVQS--------DIWSMGLSLVE-MAVGRYPIPPPDAKEL 271 GT + +PE L+ ++ ++Q+ DI+SMG ++ G++P ++E Sbjct: 190 NNPSGTSGWRAPELLEESN-NLQTKRRLTRSIDIFSMGCVFYYILSKGKHPFGDKYSRES 248 Query: 272 ELMFG 276 ++ G Sbjct: 249 NIIRG 253 >4XHH-A nrPDB Length = 403 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 50/203 (24%), Positives = 90/203 (44%), Gaps = 17/203 (8%) Query: 73 ELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGA 132 ++G+G+ G ++ ++ SG +A I LE + Q+ E +V + + F Sbjct: 14 KIGSGSFGDIYHGTNLISGEEVA---IRLESIRSRHPQLDYESRVYKYLSGGVGIPFIRW 70 Query: 133 FYSDGEISICMEHMDGGSLDQVLKKAGR-IPEQILGKVSIAVIKGLTYLREKHKIMHRDV 191 F +GE + + + G SL+ + R + + +++ +I + Y+ + +HRD+ Sbjct: 71 FGREGEYNAMVIDLLGPSLEDLFNYCHRKFSFKTVIMLALQMICRVQYIHGR-SFIHRDI 129 Query: 192 KPSNIL--VNSRGE-IKLCDFGVSGQLIDSMAN---------SFVGTRSYMSPERLQGTH 239 KP N L V RG + + DFG+S + D + S GT Y S G Sbjct: 130 KPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTARYASVNTHLGIE 189 Query: 240 YSVQSDIWSMGLSLVEMAVGRYP 262 S + D+ S+G L+ G P Sbjct: 190 QSRRDDLESLGYMLIYFCKGSLP 212 >2BUJ-A nrPDB Length = 317 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 33/126 (26%), Positives = 55/126 (43%), Gaps = 15/126 (11%) Query: 151 LDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFG 210 ++++ K + E + + + + +GL + K HRD+KP+NIL+ G+ L D G Sbjct: 121 IERLKDKGNFLTEDQILWLLLGICRGLEAIHAK-GYAHRDLKPTNILLGDEGQPVLMDLG 179 Query: 211 VSGQLIDSMANSFVG-----------TRSYMSPERLQGTHYSV---QSDIWSMGLSLVEM 256 Q + S T SY +PE + V ++D+WS+G L M Sbjct: 180 SMNQACIHVEGSRQALTLQDWAAQRCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAM 239 Query: 257 AVGRYP 262 G P Sbjct: 240 MFGEGP 245 >2C47-A nrPDB Length = 313 Score = 42.7 bits (99), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 37/134 (27%), Positives = 56/134 (41%), Gaps = 17/134 (12%) Query: 169 VSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGE-----IKLCDFGVSGQLIDSMA--- 220 ++I +I + Y+ K +++RDVKP N LV G I + DFG++ + ID Sbjct: 105 IAIQLITRMEYVHTK-SLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKH 163 Query: 221 ------NSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELM 274 S GT YMS G S + D+ ++G + G P A L+ Sbjct: 164 IPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKER 223 Query: 275 FGCQVEGDAAETPP 288 + Q GD P Sbjct: 224 Y--QKIGDTKRATP 235 >4NT4-A nrPDB Length = 312 Score = 42.7 bits (99), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 39/148 (26%), Positives = 60/148 (40%), Gaps = 25/148 (16%) Query: 155 LKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGE-----IKLCDF 209 LK I +Q+L ++ Y+ +H +++RDVKP N L+ I + DF Sbjct: 113 LKTVLMIAKQLLHRIE--------YVHSRH-LIYRDVKPENFLIGRTSTKREKIIHIIDF 163 Query: 210 GVSGQLIDSMAN---------SFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGR 260 G++ + ID N S GT YMS G S + D+ ++G + G Sbjct: 164 GLAKEYIDLDTNRHIPYREHKSLTGTARYMSINTHMGREQSRRDDLEALGHMFMYFLRGS 223 Query: 261 YPIPPPDAKELELMFGCQVEGDAAETPP 288 P A L+ + Q GD P Sbjct: 224 LPWQGLKADTLKERY--QKIGDTKRATP 249 >4XHL-A nrPDB Length = 394 Score = 42.7 bits (99), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 49/203 (24%), Positives = 89/203 (43%), Gaps = 17/203 (8%) Query: 73 ELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGA 132 ++G+G+ G ++ ++ SG +A I LE + Q+ E +V + + F Sbjct: 14 KIGSGSFGDIYHGTNLISGEEVA---IRLESIRSRHPQLDYESRVYRYLSGGVGIPFIRW 70 Query: 133 FYSDGEISICMEHMDGGSLDQVLKKAGR-IPEQILGKVSIAVIKGLTYLREKHKIMHRDV 191 F +GE + + + G SL+ + R + + +++ + + Y+ + +HRD+ Sbjct: 71 FGREGEYNAMVIDLLGPSLEDLFNYCHRRFSFKTVIMLALQMFCRIQYIHGR-SFIHRDI 129 Query: 192 KPSNIL--VNSRGE-IKLCDFGVSGQLIDSMAN---------SFVGTRSYMSPERLQGTH 239 KP N L V RG + + DFG+S + D + S GT Y S G Sbjct: 130 KPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTARYASVNTHLGIE 189 Query: 240 YSVQSDIWSMGLSLVEMAVGRYP 262 S + D+ S+G L+ G P Sbjct: 190 QSRRDDLESLGYVLIYFCKGSLP 212 >5CLR-A nrPDB Length = 451 Score = 42.4 bits (98), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 25/74 (33%), Positives = 44/74 (59%), Gaps = 4/74 (5%) Query: 186 IMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPE---RLQGTHYSV 242 ++HRD+KP NI++++ + L DFG S + S+ GT SY++PE + +S Sbjct: 197 LIHRDLKPGNIMLDADMQCHLVDFGSSSSDKEPKPASW-GTASYLAPELNAQEDFIAFSQ 255 Query: 243 QSDIWSMGLSLVEM 256 SD++++ SL E+ Sbjct: 256 VSDLFALAYSLDEL 269 >6J6I-B nrPDB Length = 351 Score = 42.0 bits (97), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 27/106 (25%), Positives = 49/106 (46%), Gaps = 6/106 (5%) Query: 161 IPEQILGKVSIAVIKGLTYLREKH--KIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS 218 +P + K+ + +TYL I+HRDVKP ++ ++ KL D S L + Sbjct: 160 LPWSVRLKIGKEIANAVTYLHTAFPKIIIHRDVKPMHVFLDKNWTAKLSDLSFSISLPEG 219 Query: 219 M----ANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGR 260 A +GT Y+ P + + +D++S G+ L+ + G+ Sbjct: 220 KSRIEAEWVLGTFGYIDPLYHKTCFVTEYTDVYSFGICLLVIITGK 265 >2CHL-A nrPDB Length = 351 Score = 41.2 bits (95), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 35/134 (26%), Positives = 56/134 (41%), Gaps = 17/134 (12%) Query: 169 VSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGE-----IKLCDFGVSGQLIDSMA--- 220 ++I +I + Y+ K+ +++RDVKP N L+ G I + DF ++ + ID Sbjct: 131 IAIQLISRMEYVHSKN-LIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKH 189 Query: 221 ------NSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELM 274 S GT YMS G S + D+ ++G + G P A L+ Sbjct: 190 IPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKER 249 Query: 275 FGCQVEGDAAETPP 288 + Q GD P Sbjct: 250 Y--QKIGDTKRATP 261 >4AZV-A nrPDB Length = 569 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 25/71 (35%), Positives = 39/71 (54%), Gaps = 6/71 (8%) Query: 141 ICMEHMDGGSLDQVLKKAGRIP-EQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVN 199 + ME + G L +L I E+ILG ++++ L L EK H DV+P N++V+ Sbjct: 319 LVMEKLPGRLLSDMLAAGEEIDREKILG----SLLRSLAAL-EKQGFWHDDVRPWNVMVD 373 Query: 200 SRGEIKLCDFG 210 +R +L DFG Sbjct: 374 ARQHARLIDFG 384 >6DC0-A nrPDB Length = 292 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 20/49 (40%), Positives = 28/49 (57%), Gaps = 2/49 (4%) Query: 225 GTRSYMSPERLQ--GTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKEL 271 G +Y+SPE L GT+ +D+WS+G+ L + VGRYP D L Sbjct: 161 GCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSAL 209 >5CEK-A nrPDB Length = 263 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 20/49 (40%), Positives = 28/49 (57%), Gaps = 2/49 (4%) Query: 225 GTRSYMSPERLQ--GTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKEL 271 G +Y+SPE L GT+ +D+WS+G+ L + VGRYP D L Sbjct: 164 GCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSAL 212 >4AZW-A nrPDB Length = 471 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 25/71 (35%), Positives = 39/71 (54%), Gaps = 6/71 (8%) Query: 141 ICMEHMDGGSLDQVLKKAGRIP-EQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVN 199 + ME + G L +L I E+ILG ++++ L L EK H DV+P N++V+ Sbjct: 319 LVMEKLPGRLLSDMLAAGEEIDREKILG----SLLRSLAAL-EKKGFWHDDVRPWNVMVD 373 Query: 200 SRGEIKLCDFG 210 +R +L DFG Sbjct: 374 ARQHARLIDFG 384 >5USZ-A nrPDB Length = 289 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 47/184 (25%), Positives = 78/184 (42%), Gaps = 35/184 (19%) Query: 125 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIA-VIKGLTYLREK 183 ++V YG E + E + GSLD LKK IL K+ +A + + E+ Sbjct: 73 HLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCI-NILWKLEVAKQLAAAMHFLEE 131 Query: 184 HKIMHRDVKPSNILVNSRGE--------IKLCDFGVSGQLIDSMANSFVGTR-SYMSPER 234 + ++H +V NIL+ + IKL D G+S I + + R ++ PE Sbjct: 132 NTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGIS---ITVLPKDILQERIPWVPPEC 188 Query: 235 LQG-THYSVQSDIWSMGLSLVEMAVG-------------------RYPIPPPDAKEL-EL 273 ++ + ++ +D WS G +L E+ G R+ +P P A EL L Sbjct: 189 IENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKAAELANL 248 Query: 274 MFGC 277 + C Sbjct: 249 INNC 252 >6HV0-A nrPDB Length = 416 Score = 39.3 bits (90), Expect = 0.003, Method: Compositional matrix adjust. Identities = 56/225 (24%), Positives = 98/225 (43%), Gaps = 35/225 (15%) Query: 74 LGAG-NGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGA 132 LG G G +V++ G+ R + I P + RE+Q+L E + V Y Sbjct: 16 LGHGAEGTIVYR------GMFDNRDVAVKRILPECFSFADREVQLLRESDEHPNVIRYFC 69 Query: 133 FYSDGEISICMEHMDGGSLDQVLKKA-----GRIPEQILGKVSIAVIKGLTYLREKHKIM 187 D + + +L + +++ G P +L + + GL +L I+ Sbjct: 70 TEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITLLQQTT----SGLAHLHSL-NIV 124 Query: 188 HRDVKPSNILV---NSRGEIK--LCDFGVSGQLI-----DSMANSFVGTRSYMSPERL-- 235 HRD+KP NIL+ N+ G+IK + DFG+ +L S + GT +++PE L Sbjct: 125 HRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSE 184 Query: 236 ---QGTHYSVQSDIWSMGLSLVE-MAVGRYPIPPPDAKELELMFG 276 + Y+V DI+S G ++ G +P ++ ++ G Sbjct: 185 DCKENPTYTV--DIFSAGCVFYYVISEGSHPFGKSLQRQANILLG 227 >4PL5-B nrPDB Length = 435 Score = 39.3 bits (90), Expect = 0.003, Method: Compositional matrix adjust. Identities = 57/225 (25%), Positives = 96/225 (42%), Gaps = 35/225 (15%) Query: 74 LGAG-NGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGA 132 LG G G +V+K G+ R + I P + RE+Q+L E + V Y Sbjct: 35 LGHGAEGTIVYK------GMFDNRDVAVKRILPECFSFADREVQLLRESDEHPNVIRYFC 88 Query: 133 FYSDGEISICMEHMDGGSLDQVLKKA-----GRIPEQILGKVSIAVIKGLTYLREKHKIM 187 D + + +L + +++ G P +L + + GL +L I+ Sbjct: 89 TEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITLLHQTT----SGLAHLHSL-NIV 143 Query: 188 HRDVKPSNILV---NSRGEIK--LCDFGVSGQLI-----DSMANSFVGTRSYMSPERL-- 235 HRD+KP NIL+ N+ G IK + DFG+ +L S + GT +++PE L Sbjct: 144 HRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSE 203 Query: 236 ---QGTHYSVQSDIWSMGLSLVE-MAVGRYPIPPPDAKELELMFG 276 Y+V DI+S G ++ G +P ++ ++ G Sbjct: 204 DCKDNPTYTV--DIFSAGCVFYYVISEGYHPFGKSLQRQANILLG 246 >4TN6-A nrPDB Length = 318 Score = 38.1 bits (87), Expect = 0.006, Method: Compositional matrix adjust. Identities = 33/141 (23%), Positives = 66/141 (46%), Gaps = 14/141 (9%) Query: 135 SDGEISICMEHMDGGSLDQVLKKAGR-IPEQILGKVSIAVIKGLTYLREKHKIMHRDVKP 193 ++G+ ++ + + G SL+ + R + + ++ +I + Y+ K+ +HRDVKP Sbjct: 73 AEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKN-FIHRDVKP 131 Query: 194 SNIL--VNSRGE-IKLCDFGVSGQLIDSMAN---------SFVGTRSYMSPERLQGTHYS 241 N L + +G + + DFG++ + D+ + + GT Y S G S Sbjct: 132 DNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQS 191 Query: 242 VQSDIWSMGLSLVEMAVGRYP 262 + D+ S+G L+ +G P Sbjct: 192 RRDDLESLGYVLMYFNLGSLP 212 >5UV4-A nrPDB Length = 311 Score = 38.1 bits (87), Expect = 0.006, Method: Compositional matrix adjust. Identities = 40/173 (23%), Positives = 79/173 (45%), Gaps = 27/173 (15%) Query: 108 RNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICM--EHMDGGSLDQVLKKAG--RIPE 163 + + RE++ L P +V G ++ E M ++ D SL L + +P Sbjct: 65 KKEFSREIKKLGSVRHPNLVPLRGYYWGPKEHERIMISDYADATSLSTYLSEFDERNLPP 124 Query: 164 QILGK---VSIAVIKGLTYLREKHKIMHRDVKPSNILV-NSRGEIKLCDF---------G 210 G+ ++I + + L YL + I H ++K SN+L+ NS + D+ G Sbjct: 125 LSAGQRLNIAIDIARCLDYLHNERVIPHGNIKSSNVLIQNSTPSALVTDYSLHRLMTPIG 184 Query: 211 VSGQLIDSMANSFVGTRSYMSPERLQGTHY---SVQSDIWSMGLSLVEMAVGR 260 ++ Q++++ A + SP T S++SD+++ G+ L+E+ G+ Sbjct: 185 MAEQVLNAGALGY-------SPPEFSSTSKPCPSLKSDVYAFGVILLELLTGK 230 >1CSN-A nrPDB Length = 298 Score = 38.1 bits (87), Expect = 0.007, Method: Compositional matrix adjust. Identities = 49/206 (23%), Positives = 94/206 (45%), Gaps = 23/206 (11%) Query: 74 LGAGNGGVVFKVSHKPSGLVMARKLI-HLEIKPAIRNQIIRELQVLHECNSPYIVGFYGA 132 +G G+ GV+F+ ++ + +A K P +R++ R ++L C V ++G Sbjct: 18 IGEGSFGVIFEGTNLLNNQQVAIKFEPRRSDAPQLRDEY-RTYKLLAGCTGIPNVYYFG- 75 Query: 133 FYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHK--IMHRD 190 +G ++ + + G SL+ +L GR + + V++A + L ++ H+ +++RD Sbjct: 76 --QEGLHNVLVIDLLGPSLEDLLDLCGR--KFSVKTVAMAAKQMLARVQSIHEKSLVYRD 131 Query: 191 VKPSNILV---NSRGE--IKLCDFGVSGQLIDSMANSFV---------GTRSYMSPERLQ 236 +KP N L+ NS+ I + DFG+ D + + GT YMS Sbjct: 132 IKPDNFLIGRPNSKNANMIYVVDFGMVKFYRDPVTKQHIPYREKKNLSGTARYMSINTHL 191 Query: 237 GTHYSVQSDIWSMGLSLVEMAVGRYP 262 G S + D+ ++G + G P Sbjct: 192 GREQSRRDDLEALGHVFMYFLRGSLP 217 >2LAV-A nrPDB Length = 361 Score = 38.1 bits (87), Expect = 0.007, Method: Compositional matrix adjust. Identities = 29/127 (22%), Positives = 59/127 (46%), Gaps = 13/127 (10%) Query: 148 GGSLDQVLK-KAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRG--EI 204 G L ++ + A R + + ++S+ ++ L Y+ E H+ +H D+K SN+L+N + ++ Sbjct: 135 GSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHE-HEYVHGDIKASNLLLNYKNPDQV 193 Query: 205 KLCDF---------GVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVE 255 L D+ GV + + GT + S + G S + D+ +G +++ Sbjct: 194 YLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQ 253 Query: 256 MAVGRYP 262 G P Sbjct: 254 WLTGHLP 260 >2RSV-A nrPDB Length = 403 Score = 37.7 bits (86), Expect = 0.009, Method: Compositional matrix adjust. Identities = 39/186 (20%), Positives = 79/186 (42%), Gaps = 26/186 (13%) Query: 148 GGSLDQVLK-KAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRG--EI 204 G L ++ + A R + + ++S+ ++ L Y+ E H+ +H D+K SN+L+N + ++ Sbjct: 142 GSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHE-HEYVHGDIKASNLLLNYKNPDQV 200 Query: 205 KLCDF---------GVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVE 255 L D+ GV + + GT + S + G S + D+ +G +++ Sbjct: 201 YLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQ 260 Query: 256 MAVGRYPIP-----PPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAI 310 G P P ++ ++ + + + P PG ++ Y M Sbjct: 261 WLTGHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGE-IAKY-------MET 312 Query: 311 FELLDY 316 +LLDY Sbjct: 313 VKLLDY 318 >3SV0-A nrPDB Length = 483 Score = 36.6 bits (83), Expect = 0.020, Method: Compositional matrix adjust. Identities = 31/143 (21%), Positives = 64/143 (44%), Gaps = 14/143 (9%) Query: 133 FYSDGEISICMEHMDGGSLDQVLKKAGR-IPEQILGKVSIAVIKGLTYLREKHKIMHRDV 191 F +G+ ++ + + G SL+ + R + + + ++ +I + ++ K +HRD+ Sbjct: 71 FGVEGDYNVLVMDLLGPSLEDLFNFCSRKLSLKTVLMLADQMINRVEFVHSK-SFLHRDI 129 Query: 192 KPSNILV---NSRGEIKLCDFGVSGQLIDSMAN---------SFVGTRSYMSPERLQGTH 239 KP N L+ ++ + DFG++ + D+ + + GT Y S G Sbjct: 130 KPDNFLMGLGRRANQVYIIDFGLAKKYRDTSTHQHIPYRENKNLTGTARYASVNTHLGIE 189 Query: 240 YSVQSDIWSMGLSLVEMAVGRYP 262 S + D+ S+G L+ G P Sbjct: 190 QSRRDDLESLGYVLMYFLRGSLP 212 >5FQD-C nrPDB Length = 341 Score = 33.1 bits (74), Expect = 0.20, Method: Compositional matrix adjust. Identities = 47/219 (21%), Positives = 94/219 (42%), Gaps = 37/219 (16%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYI- 126 ++ + ++G+G+ G ++ + +G +A KL +Q R Q+L+E I Sbjct: 21 YKLVRKIGSGSFGDIYLAINITNGEEVAVKL---------ESQKARHPQLLYESKLYKIL 71 Query: 127 --------VGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR-IPEQILGKVSIAVIKGL 177 + +YG + + ++ + + G SL+ + R + + ++ +I + Sbjct: 72 QGGVGIPHIRWYG---QEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRI 128 Query: 178 TYLREKHKIMHRDVKPSNILV---NSRGEIKLCDFGVSGQLIDSMA---------NSFVG 225 Y+ K+ +HRD+KP N L+ ++ L DFG++ + D+ + G Sbjct: 129 EYVHTKN-FIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTG 187 Query: 226 TRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIP 264 T Y S G S + D+ S+G L M R +P Sbjct: 188 TARYASINAHLGIEQSRRDDMESLGYVL--MYFNRTSLP 224 >6EQI-C nrPDB Length = 433 Score = 32.3 bits (72), Expect = 0.35, Method: Compositional matrix adjust. Identities = 28/89 (31%), Positives = 40/89 (44%), Gaps = 25/89 (28%) Query: 184 HKIMHRDVKPSNILVN-SRGE----IKLCDFGVSGQLIDSMANSFV----------GTRS 228 H I HRD+K NILV+ S G+ I + DFG L D + G R+ Sbjct: 186 HNISHRDLKSDNILVDLSEGDAYPTIVITDFGCC--LCDKQNGLVIPYRSEDQDKGGNRA 243 Query: 229 YMSPE-------RLQGTHYSVQSDIWSMG 250 M+PE +Y +SD+W++G Sbjct: 244 LMAPEIANAKPGTFSWLNYK-KSDLWAVG 271 >4OAU-C nrPDB Length = 699 Score = 32.3 bits (72), Expect = 0.36, Method: Compositional matrix adjust. Identities = 27/109 (24%), Positives = 46/109 (42%), Gaps = 13/109 (11%) Query: 113 RELQVLHECN-SPYIVGFYGAFYSDGEISICM---EHMDGGSLD-----QVLKKAGRIPE 163 RE+ L + ++V FYG+ G + +C+ E LD V + Sbjct: 383 REVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFAR 442 Query: 164 QILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVS 212 +L ++ K + L H+D++P NIL++S+ L DF S Sbjct: 443 NVLS----SIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKS 487 >4O1O-A nrPDB Length = 717 Score = 31.2 bits (69), Expect = 0.74, Method: Compositional matrix adjust. Identities = 28/98 (28%), Positives = 44/98 (44%), Gaps = 19/98 (19%) Query: 126 IVGFYGAFYSDGE-ISICM--------EHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKG 176 +V FYG+ SDG + +C+ EH+ D V + IL + A+ Sbjct: 400 VVTFYGS-ESDGSCLHVCLALCEYTLQEHLANHRGDAVPNEEDESARNILSSLFKAI--- 455 Query: 177 LTYLREKHK--IMHRDVKPSNILVNSRGEIKLCDFGVS 212 E H+ H+D++P NIL++S+ L DF S Sbjct: 456 ----GELHRSGYSHQDLQPQNILIDSKNGTFLADFDKS 489 >6BME-A nrPDB Length = 128 Score = 30.4 bits (67), Expect = 1.6, Method: Composition-based stats. Identities = 13/32 (40%), Positives = 17/32 (53%) Query: 206 LCDFGVSGQLIDSMANSFVGTRSYMSPERLQG 237 L + GV +LID A +G R PER +G Sbjct: 94 LKEMGVGQELIDEAAGVLIGVRPLFDPERYKG 125 >4IX6-A nrPDB Length = 350 Score = 30.0 bits (66), Expect = 1.9, Method: Compositional matrix adjust. Identities = 18/51 (35%), Positives = 29/51 (56%), Gaps = 4/51 (7%) Query: 166 LGKVSIAVIKGLTYLREKHK--IMHRDVKPSNILVNSR--GEIKLCDFGVS 212 LG A+ + L L H+ ++HRDVKP+N++ + G +KL D G + Sbjct: 142 LGVTKKAMRELLGSLARLHECGVVHRDVKPANLIAAEKDGGVLKLIDLGAA 192 >3RC8-A nrPDB Length = 677 Score = 29.6 bits (65), Expect = 2.1, Method: Compositional matrix adjust. Identities = 21/70 (30%), Positives = 36/70 (51%), Gaps = 4/70 (5%) Query: 91 GLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAF---YSDGEISICMEHMD 147 L + R + + IKP+I + REL+ + + I G G F + +GE++ M H D Sbjct: 387 NLSIRRIIFYSLIKPSINEKGERELEPITTSQALQIAGRAGRFSSRFKEGEVTT-MNHED 445 Query: 148 GGSLDQVLKK 157 L ++LK+ Sbjct: 446 LSLLKEILKR 455 >5X1R-A nrPDB Length = 302 Score = 29.3 bits (64), Expect = 3.5, Method: Compositional matrix adjust. Identities = 33/167 (19%), Positives = 71/167 (42%), Gaps = 16/167 (9%) Query: 109 NQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQV-LKKAGRIPEQILG 167 N I+E ++L + P ++ + +G + + G +L + ++ +I E + Sbjct: 84 NSFIQEARLLARFSHPGLLHVLRFWEENGTAYMGTQFYSGTTLKNLQAQQPEKIDEAWIR 143 Query: 168 KVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTR 227 ++ + + + ++ +HRD+ NI + L DFG + + I ++++ T Sbjct: 144 RLLPPLFSAINTIHQE-GYLHRDISLDNIQIQESQLPVLLDFGSARKEIGNLSDE---TE 199 Query: 228 SYMSPERLQGTHYSVQS--------DIWSMGLSLVEMAVGRYPIPPP 266 + P Y+ S DI+++G L + VG PPP Sbjct: 200 IVLKPGFAPIEQYTENSDGEQGPWTDIYALGAVLHTLIVGS---PPP 243 >2JII-A nrPDB Length = 352 Score = 28.5 bits (62), Expect = 5.4, Method: Compositional matrix adjust. Identities = 26/113 (23%), Positives = 59/113 (52%), Gaps = 12/113 (10%) Query: 161 IPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVN--SRGEIKLCDFGVSGQLIDS 218 + E+ + +V+ ++ L +L E ++ +H +V NI V+ + ++ L +G + + S Sbjct: 156 LSERSVLQVACRLLDALEFLHE-NEYVHGNVTAENIFVDPEDQSQVTLAGYGFAFRYCPS 214 Query: 219 MAN-SFV-GTRS-------YMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYP 262 + ++V G+RS ++S + +G S +SD+ S+G +++ G P Sbjct: 215 GKHVAYVEGSRSPHEGDLEFISMDLHKGCGPSRRSDLQSLGYCMLKWLYGFLP 267 >1XOC-A nrPDB Length = 520 Score = 28.1 bits (61), Expect = 6.0, Method: Compositional matrix adjust. Identities = 14/48 (29%), Positives = 25/48 (52%) Query: 136 DGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREK 183 D E+ +++ DG + L +P+ ILG V IA ++ + R+K Sbjct: 134 DYEVLFKLKYKDGNFYNNALDSTAILPKHILGNVPIADLEENEFNRKK 181 >4DA1-A nrPDB Length = 389 Score = 28.1 bits (61), Expect = 7.7, Method: Compositional matrix adjust. Identities = 17/46 (36%), Positives = 21/46 (45%) Query: 329 VFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGW 374 V S E DFVN+C N A A +Q + + S A V F W Sbjct: 333 VNSQEICDFVNQCHDPNEAAHAVTEQAIQYGTEDNSTAVVVPFGAW 378 >2IQ1-A nrPDB Length = 274 Score = 27.7 bits (60), Expect = 8.4, Method: Compositional matrix adjust. Identities = 17/46 (36%), Positives = 21/46 (45%) Query: 329 VFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGW 374 V S E DFVN+C N A A +Q + + S A V F W Sbjct: 219 VNSQEICDFVNQCHDPNEAAHAVTEQAIQYGTEDNSTAVVVPFGAW 264 >2ZSG-A nrPDB Length = 359 Score = 27.7 bits (60), Expect = 9.6, Method: Compositional matrix adjust. Identities = 10/26 (38%), Positives = 18/26 (69%) Query: 204 IKLCDFGVSGQLIDSMANSFVGTRSY 229 +K+ GV+G+L+DS+A F+ + Y Sbjct: 258 LKIAKAGVTGKLLDSVAREFIREKGY 283 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 5KKR-C nrPDB 558 e-159 3EQC-A nrPDB 498 e-141 1S9I-A nrPDB 422 e-118 4AN9-A nrPDB 397 e-111 3COM-A nrPDB 288 2e-78 4LG4-A nrPDB 278 4e-75 6AO5-A nrPDB 275 3e-74 4KRC-A nrPDB 273 8e-74 3NCG-A nrPDB 272 2e-73 3DFA-A nrPDB 272 2e-73 2BPM-A nrPDB 271 3e-73 2XIK-A nrPDB 268 3e-72 4MVF-A nrPDB 268 4e-72 6GU6-A nrPDB 266 9e-72 5JN2-A nrPDB 265 2e-71 3NIZ-A nrPDB 265 2e-71 4AGU-A nrPDB 265 4e-71 4IC8-A nrPDB 264 5e-71 2VN9-A nrPDB 264 6e-71 3VN9-A nrPDB 264 6e-71 3HZT-A nrPDB 263 1e-70 4QMW-A nrPDB 263 1e-70 3ALO-A nrPDB 263 1e-70 2BDW-A nrPDB 263 1e-70 3DXN-A nrPDB 262 2e-70 5FG8-A nrPDB 262 2e-70 3FME-A nrPDB 261 3e-70 5WAX-A nrPDB 261 3e-70 3KK8-A nrPDB 261 3e-70 4FZF-B nrPDB 261 3e-70 2V7O-A nrPDB 261 3e-70 3MA6-A nrPDB 261 5e-70 4REW-A nrPDB 260 9e-70 5IG1-A nrPDB 259 1e-69 4C0T-A nrPDB 259 1e-69 3DAK-A nrPDB 259 1e-69 4FG9-A nrPDB 259 1e-69 3LIJ-A nrPDB 259 1e-69 2JC6-A nrPDB 259 2e-69 4CFH-A nrPDB 258 3e-69 4CFF-A nrPDB 258 3e-69 5KCV-A nrPDB 258 3e-69 5U6Y-A nrPDB 258 4e-69 4RED-A nrPDB 258 5e-69 2QNJ-A nrPDB 257 5e-69 4AU8-A nrPDB 257 5e-69 5ES1-A nrPDB 257 6e-69 5EZV-A nrPDB 257 7e-69 5XZW-A nrPDB 256 9e-69 5X3F-B nrPDB 256 9e-69 3MIA-A nrPDB 256 1e-68 2VZ6-A nrPDB 256 1e-68 4BBM-A nrPDB 256 1e-68 3MV5-A nrPDB 256 1e-68 3BHH-A nrPDB 255 2e-68 5AWM-A nrPDB 255 2e-68 3ZDU-A nrPDB 255 3e-68 5J5T-A nrPDB 255 3e-68 5N23-A nrPDB 255 3e-68 5KZ7-A nrPDB 254 3e-68 3SOA-A nrPDB 254 4e-68 2F9G-A nrPDB 254 6e-68 5DBX-A nrPDB 254 7e-68 6FD3-A nrPDB 254 7e-68 2JDO-A nrPDB 253 8e-68 3MN3-A nrPDB 253 1e-67 2YZA-A nrPDB 253 1e-67 3D2K-A nrPDB 253 1e-67 1JNK-A nrPDB 253 1e-67 5D7A-A nrPDB 252 2e-67 4UZD-A nrPDB 252 2e-67 2JAM-A nrPDB 251 3e-67 3TAC-A nrPDB 251 3e-67 4JDH-A nrPDB 251 3e-67 2W4O-A nrPDB 251 3e-67 2Q0N-A nrPDB 251 4e-67 4KS7-A nrPDB 251 4e-67 4XBR-A nrPDB 251 5e-67 4FIE-A nrPDB 251 5e-67 4QNY-A nrPDB 251 5e-67 3E7O-A nrPDB 250 7e-67 5D9K-A nrPDB 250 7e-67 4EWQ-A nrPDB 250 7e-67 4PDS-A nrPDB 250 8e-67 1PHK-A nrPDB 250 8e-67 2Z7Q-A nrPDB 250 9e-67 5B2L-A nrPDB 250 9e-67 5JZN-A nrPDB 250 9e-67 2XS0-A nrPDB 249 1e-66 1FOT-A nrPDB 249 2e-66 3UC3-A nrPDB 249 2e-66 2F57-A nrPDB 248 3e-66 4YZB-A nrPDB 248 3e-66 3FI2-A nrPDB 248 3e-66 3Q5I-A nrPDB 248 3e-66 3OHT-A nrPDB 248 4e-66 3GUB-A nrPDB 248 4e-66 3ZUT-A nrPDB 247 7e-66 2HAK-A nrPDB 247 7e-66 1G3N-A nrPDB 246 9e-66 1V0B-A nrPDB 246 9e-66 2J90-A nrPDB 246 1e-65 4RGJ-A nrPDB 246 1e-65 3Q53-A nrPDB 246 2e-65 2UV2-A nrPDB 246 2e-65 3H4J-B nrPDB 246 2e-65 6C9D-A nrPDB 245 2e-65 4JXF-A nrPDB 245 2e-65 5Z33-A nrPDB 244 3e-65 5F9E-A nrPDB 244 5e-65 3UDB-A nrPDB 244 5e-65 2YAB-A nrPDB 244 5e-65 1UA2-A nrPDB 244 6e-65 5G6V-A nrPDB 243 9e-65 4CQG-A nrPDB 243 1e-64 4D28-A nrPDB 243 1e-64 3OZ6-A nrPDB 243 1e-64 4D2V-A nrPDB 243 2e-64 4NIF-A nrPDB 242 2e-64 4RLP-A nrPDB 242 2e-64 4L42-A nrPDB 242 2e-64 4WNO-A nrPDB 242 2e-64 6E9W-A nrPDB 242 2e-64 4WB7-A nrPDB 242 2e-64 2Y7J-A nrPDB 242 2e-64 3IS5-A nrPDB 242 2e-64 4CZT-A nrPDB 242 3e-64 1CM8-A nrPDB 241 3e-64 6HXF-B nrPDB 241 3e-64 6FDY-U nrPDB 241 3e-64 4BGQ-A nrPDB 241 4e-64 3GC9-A nrPDB 241 5e-64 2A27-A nrPDB 241 5e-64 6ED6-A nrPDB 241 6e-64 5YKS-A nrPDB 241 6e-64 6CQF-A nrPDB 240 6e-64 4ZSG-A nrPDB 240 7e-64 3FXW-A nrPDB 239 1e-63 1ZWS-A nrPDB 239 1e-63 6DTL-A nrPDB 239 1e-63 4CSV-A nrPDB 239 2e-63 4JG6-A nrPDB 237 5e-63 3TXO-A nrPDB 237 7e-63 3HDN-A nrPDB 236 1e-62 2WQN-A nrPDB 236 1e-62 4MYG-A nrPDB 236 2e-62 6QAU-A nrPDB 235 2e-62 4B6L-A nrPDB 234 3e-62 5DYK-A nrPDB 234 4e-62 5EFQ-A nrPDB 234 4e-62 4NST-A nrPDB 233 1e-61 2YCR-A nrPDB 233 1e-61 4QTB-A nrPDB 232 2e-61 4RA4-A nrPDB 232 2e-61 5NGU-A nrPDB 232 2e-61 4I6B-A nrPDB 231 3e-61 1VZO-A nrPDB 231 3e-61 4U41-A nrPDB 231 3e-61 3A8W-A nrPDB 231 4e-61 4B8L-A nrPDB 231 5e-61 3I6U-A nrPDB 231 5e-61 3GC0-A nrPDB 231 5e-61 1U5R-A nrPDB 231 5e-61 2HW6-A nrPDB 231 5e-61 3F3Z-A nrPDB 230 6e-61 6CMJ-A nrPDB 230 7e-61 4YNZ-A nrPDB 230 7e-61 2GCD-A nrPDB 230 7e-61 5FET-A nrPDB 230 7e-61 3PFQ-A nrPDB 230 8e-61 5Y86-A nrPDB 230 9e-61 2XYN-A nrPDB 229 2e-60 1NY3-A nrPDB 229 2e-60 2FO0-A nrPDB 229 2e-60 2I0E-A nrPDB 229 2e-60 3KA0-A nrPDB 228 2e-60 4XEY-B nrPDB 228 3e-60 6NPU-A nrPDB 228 3e-60 2OZA-A nrPDB 228 3e-60 3NYO-A nrPDB 228 3e-60 3PPZ-A nrPDB 228 5e-60 4J52-A nrPDB 227 8e-60 4GS6-A nrPDB 227 9e-60 2OU7-A nrPDB 226 1e-59 5LOH-A nrPDB 226 1e-59 2X4F-A nrPDB 226 1e-59 6CKI-A nrPDB 226 2e-59 5ZTN-A nrPDB 225 3e-59 4O2Z-A nrPDB 224 3e-59 4APC-A nrPDB 224 3e-59 4UY9-A nrPDB 224 4e-59 3DB8-A nrPDB 224 4e-59 1KOB-A nrPDB 224 5e-59 3UTO-A nrPDB 224 5e-59 3ORZ-A nrPDB 223 9e-59 3TKU-A nrPDB 223 1e-58 4AF3-A nrPDB 223 1e-58 6BDL-A nrPDB 223 2e-58 3N9X-A nrPDB 222 2e-58 1KOA-A nrPDB 222 2e-58 2W96-B nrPDB 221 3e-58 4AW2-A nrPDB 221 4e-58 5YV8-A nrPDB 221 4e-58 4TNB-A nrPDB 221 4e-58 2XNP-A nrPDB 221 4e-58 3LM0-A nrPDB 221 5e-58 4E7W-A nrPDB 220 6e-58 3DTC-A nrPDB 220 7e-58 2BRG-A nrPDB 220 9e-58 5O2C-A nrPDB 220 1e-57 4AT3-A nrPDB 220 1e-57 3NIE-A nrPDB 219 1e-57 5O2B-A nrPDB 219 1e-57 4FR4-A nrPDB 218 3e-57 5X8I-B nrPDB 218 3e-57 4E93-A nrPDB 218 5e-57 3RP9-A nrPDB 217 6e-57 5AIR-A nrPDB 217 7e-57 4EBW-A nrPDB 217 8e-57 4UYA-A nrPDB 217 9e-57 5UUU-A nrPDB 216 1e-56 5VO2-A nrPDB 216 1e-56 3KN6-A nrPDB 216 1e-56 3V5Q-A nrPDB 216 1e-56 6FYV-A nrPDB 216 2e-56 4XI2-A nrPDB 215 2e-56 3PVW-A nrPDB 215 3e-56 2J0K-A nrPDB 214 4e-56 4PWN-A nrPDB 214 4e-56 3C51-A nrPDB 214 4e-56 4XUF-A nrPDB 214 5e-56 5MJB-A nrPDB 214 5e-56 5X02-A nrPDB 214 6e-56 4P5Q-A nrPDB 214 7e-56 6E4F-A nrPDB 213 8e-56 2Y6O-A nrPDB 213 9e-56 6O6Q-A nrPDB 213 9e-56 2H8H-A nrPDB 213 1e-55 6F3F-A nrPDB 213 1e-55 6E2O-A nrPDB 213 1e-55 3SXS-A nrPDB 213 1e-55 2WTK-B nrPDB 213 1e-55 1JPA-A nrPDB 213 2e-55 3DKO-A nrPDB 212 2e-55 6BXI-A nrPDB 212 2e-55 5KMM-A nrPDB 212 2e-55 4EQM-A nrPDB 212 3e-55 3QGY-A nrPDB 211 4e-55 5X5O-A nrPDB 211 6e-55 4Y93-A nrPDB 211 6e-55 2R2P-A nrPDB 211 6e-55 5SYS-A nrPDB 210 7e-55 6FEX-A nrPDB 210 1e-54 3A4O-X nrPDB 209 2e-54 5L6P-A nrPDB 209 2e-54 3RAW-A nrPDB 209 2e-54 2DQ7-X nrPDB 209 2e-54 2WO6-A nrPDB 209 2e-54 4PDO-A nrPDB 208 3e-54 3CJF-A nrPDB 208 3e-54 4H1J-A nrPDB 208 4e-54 3E3P-A nrPDB 208 4e-54 2I6L-A nrPDB 208 4e-54 3HKO-A nrPDB 207 5e-54 2VD5-A nrPDB 207 5e-54 6BSD-A nrPDB 207 5e-54 4OLI-A nrPDB 207 5e-54 3BBT-B nrPDB 207 5e-54 4KIK-B nrPDB 207 5e-54 5H2U-A nrPDB 207 6e-54 4TPT-A nrPDB 207 9e-54 6DBM-A nrPDB 206 1e-53 4YHJ-A nrPDB 206 1e-53 5UNP-A nrPDB 206 1e-53 3GQL-A nrPDB 206 2e-53 6CTH-A nrPDB 205 2e-53 6GQK-A nrPDB 205 2e-53 2VWV-A nrPDB 205 2e-53 3TT0-A nrPDB 205 2e-53 3BEA-A nrPDB 205 3e-53 4OTD-A nrPDB 205 3e-53 5A46-A nrPDB 205 3e-53 3PG1-A nrPDB 205 3e-53 5AMN-A nrPDB 205 3e-53 3PP0-A nrPDB 205 3e-53 3IO7-A nrPDB 205 3e-53 2OGV-A nrPDB 205 3e-53 4CRS-A nrPDB 204 4e-53 2W1I-A nrPDB 204 4e-53 3QA8-A nrPDB 204 6e-53 2PL0-A nrPDB 204 7e-53 3KRL-A nrPDB 204 7e-53 1LUF-A nrPDB 203 9e-53 4XLV-A nrPDB 203 1e-52 1U59-A nrPDB 203 1e-52 4E20-A nrPDB 202 2e-52 3M42-A nrPDB 202 2e-52 1K9A-A nrPDB 202 2e-52 1BYG-A nrPDB 202 2e-52 3ORP-A nrPDB 202 2e-52 4XCU-A nrPDB 202 2e-52 2OZO-A nrPDB 202 3e-52 5TQX-A nrPDB 202 3e-52 4HVI-A nrPDB 202 3e-52 5GNK-A nrPDB 201 3e-52 3KUL-B nrPDB 201 4e-52 6DBN-A nrPDB 201 4e-52 5FM2-A nrPDB 201 5e-52 5TOS-A nrPDB 201 5e-52 3LZB-A nrPDB 201 6e-52 2PVN-A nrPDB 200 7e-52 2HK5-A nrPDB 200 7e-52 4R7H-A nrPDB 200 7e-52 5HVK-A nrPDB 200 9e-52 4M7I-A nrPDB 200 1e-51 2PSQ-A nrPDB 199 1e-51 5GRN-A nrPDB 199 2e-51 5O0Y-A nrPDB 199 2e-51 5HI2-A nrPDB 199 2e-51 3QUP-A nrPDB 198 3e-51 3I81-A nrPDB 198 3e-51 6CCF-A nrPDB 198 3e-51 2PMN-X nrPDB 198 4e-51 4IAN-A nrPDB 198 4e-51 5U6B-A nrPDB 197 5e-51 5EG3-A nrPDB 197 5e-51 1FVR-A nrPDB 197 7e-51 6GVJ-A nrPDB 197 7e-51 4FL3-A nrPDB 197 7e-51 3EB0-A nrPDB 197 8e-51 6FER-A nrPDB 197 8e-51 4F0G-A nrPDB 196 1e-50 2X7G-A nrPDB 196 2e-50 4K33-A nrPDB 196 2e-50 3G0E-A nrPDB 195 2e-50 4WUA-A nrPDB 195 3e-50 4HZS-A nrPDB 195 3e-50 5HIE-A nrPDB 194 4e-50 3ZBF-A nrPDB 194 4e-50 4LRM-A nrPDB 194 5e-50 3HMP-A nrPDB 194 5e-50 1U54-B nrPDB 193 9e-50 2ZMD-A nrPDB 193 1e-49 5AP3-A nrPDB 192 1e-49 4YFF-A nrPDB 192 2e-49 5C26-A nrPDB 192 2e-49 3UIM-A nrPDB 192 2e-49 1AD5-A nrPDB 191 3e-49 3AOX-A nrPDB 191 3e-49 4IDT-A nrPDB 191 4e-49 1TKI-A nrPDB 191 4e-49 5UIU-A nrPDB 191 5e-49 4NEU-A nrPDB 191 5e-49 3OMV-A nrPDB 191 7e-49 3DLS-A nrPDB 191 7e-49 5LPZ-A nrPDB 190 8e-49 5LPV-A nrPDB 190 1e-48 5HLW-A nrPDB 189 2e-48 4G3E-A nrPDB 189 2e-48 6B2Q-A nrPDB 188 4e-48 3PLS-A nrPDB 188 4e-48 2JD5-A nrPDB 188 4e-48 4X3F-A nrPDB 187 5e-48 4OW8-A nrPDB 187 5e-48 6HMD-A nrPDB 187 6e-48 3C1X-A nrPDB 187 7e-48 3LLT-A nrPDB 187 8e-48 2A1A-B nrPDB 187 8e-48 4MD7-E nrPDB 187 9e-48 1ZXE-A nrPDB 187 9e-48 4RC3-A nrPDB 186 1e-47 5XVU-A nrPDB 186 1e-47 5WNL-A nrPDB 186 2e-47 3BGP-A nrPDB 186 2e-47 6EII-A nrPDB 185 3e-47 6J5U-C nrPDB 184 4e-47 5TUR-A nrPDB 184 4e-47 3ZZW-A nrPDB 184 7e-47 3UIU-A nrPDB 182 3e-46 4Y83-A nrPDB 179 1e-45 5XD6-A nrPDB 178 4e-45 4X7Q-B nrPDB 178 4e-45 4C59-A nrPDB 178 4e-45 5WNO-A nrPDB 177 7e-45 4CRL-A nrPDB 177 1e-44 2WTK-C nrPDB 176 1e-44 4JLC-A nrPDB 176 2e-44 5U6C-A nrPDB 176 2e-44 4EUT-A nrPDB 176 2e-44 4EUU-A nrPDB 174 6e-44 2H34-A nrPDB 174 8e-44 5VD3-A nrPDB 173 9e-44 3MDY-A nrPDB 173 1e-43 2QKW-B nrPDB 173 1e-43 6O8B-A nrPDB 172 2e-43 3LMG-A nrPDB 172 2e-43 6NT9-A nrPDB 172 2e-43 4LFI-A nrPDB 172 3e-43 3Q4U-A nrPDB 170 1e-42 5E8V-A nrPDB 167 8e-42 6BFN-A nrPDB 166 1e-41 5AR8-A nrPDB 165 3e-41 3G2F-A nrPDB 165 4e-41 3MY0-A nrPDB 164 4e-41 1PY5-A nrPDB 164 8e-41 4M66-A nrPDB 163 1e-40 4LQP-A nrPDB 163 2e-40 2RIO-A nrPDB 162 3e-40 3SOC-A nrPDB 159 1e-39 4F9B-A nrPDB 159 2e-39 2BUJ-A nrPDB 157 7e-39 5J0A-A nrPDB 152 2e-37 5VC6-A nrPDB 152 4e-37 5TE0-A nrPDB 151 4e-37 2QLU-A nrPDB 150 9e-37 5IKW-A nrPDB 150 1e-36 4BTK-A nrPDB 148 4e-36 4NFN-A nrPDB 147 7e-36 4L68-A nrPDB 145 4e-35 4M69-B nrPDB 144 8e-35 5X18-A nrPDB 143 1e-34 4BTF-A nrPDB 143 1e-34 3QD2-B nrPDB 140 8e-34 5VDK-A nrPDB 140 1e-33 2CHL-A nrPDB 137 6e-33 5M07-A nrPDB 137 7e-33 4XHH-A nrPDB 136 2e-32 2C47-A nrPDB 136 2e-32 2CMW-A nrPDB 134 5e-32 4XHL-A nrPDB 134 7e-32 4NT4-A nrPDB 134 7e-32 3VHK-A nrPDB 132 2e-31 4RT7-A nrPDB 132 3e-31 3HNG-A nrPDB 131 5e-31 5L2Q-C nrPDB 124 7e-29 4L00-A nrPDB 123 1e-28 6DC0-A nrPDB 122 2e-28 5CEK-A nrPDB 122 3e-28 6J6I-B nrPDB 117 8e-27 4JRN-A nrPDB 105 4e-23 5CLR-A nrPDB 87 2e-17 4AZW-A nrPDB 66 2e-11 4AZV-A nrPDB 65 4e-11 Sequences not found previously or not previously below threshold: 2Y4I-B nrPDB 148 4e-36 6HV0-A nrPDB 145 3e-35 4PL5-B nrPDB 144 6e-35 3SV0-A nrPDB 143 1e-34 5FQD-C nrPDB 143 1e-34 4TN6-A nrPDB 141 4e-34 4MWI-A nrPDB 137 1e-32 1CSN-A nrPDB 132 2e-31 5USZ-A nrPDB 118 4e-27 3REP-A nrPDB 117 9e-27 4I94-A nrPDB 115 4e-26 2PZI-A nrPDB 114 5e-26 4Y12-A nrPDB 114 1e-25 5X1R-A nrPDB 112 4e-25 5C01-A nrPDB 109 2e-24 4WOV-A nrPDB 109 2e-24 5UV4-A nrPDB 108 4e-24 5UU1-A nrPDB 100 8e-22 2RSV-A nrPDB 86 3e-17 2LAV-A nrPDB 85 4e-17 5OAT-A nrPDB 84 1e-16 6EQI-C nrPDB 81 8e-16 6EAS-A nrPDB 80 2e-15 5DMZ-A nrPDB 75 4e-14 4IX6-A nrPDB 70 2e-12 6G4J-A nrPDB 69 5e-12 5GZA-A nrPDB 67 1e-11 5GZ9-A nrPDB 67 2e-11 4OAU-C nrPDB 66 3e-11 4CI6-B nrPDB 65 7e-11 4O1O-A nrPDB 63 2e-10 2JII-A nrPDB 59 3e-09 6G38-A nrPDB 58 7e-09 6BHC-A nrPDB 51 7e-07 6EWX-A nrPDB 51 7e-07 3BYV-A nrPDB 50 2e-06 3ENH-A nrPDB 48 8e-06 4BWP-A nrPDB 47 1e-05 4CZY-B nrPDB 46 3e-05 4CYJ-A nrPDB 46 3e-05 1TQM-A nrPDB 45 5e-05 6M7Z-A nrPDB 44 8e-05 5VE6-A nrPDB 44 1e-04 3DZO-A nrPDB 44 2e-04 2W1Z-A nrPDB 43 2e-04 4WWA-A nrPDB 43 2e-04 5YK0-A nrPDB 40 0.002 4OTP-A nrPDB 40 0.002 6G5I-z nrPDB 40 0.003 6G18-v nrPDB 39 0.005 3Q60-A nrPDB 38 0.007 6FDN-A nrPDB 38 0.008 1ZP9-A nrPDB 37 0.018 2PZ1-A nrPDB 34 0.11 4BVU-A nrPDB 32 0.51 6DFL-A nrPDB 32 0.55 6GL3-A nrPDB 31 1.0 >5KKR-C nrPDB Length = 395 Score = 558 bits (1438), Expect = e-159, Method: Composition-based stats. Identities = 392/393 (99%), Positives = 392/393 (99%) Query: 1 MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV 60 MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV Sbjct: 3 MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV 62 Query: 61 GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE 120 GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE Sbjct: 63 GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE 122 Query: 121 CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL 180 CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL Sbjct: 123 CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL 182 Query: 181 REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY 240 REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY Sbjct: 183 REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY 242 Query: 241 SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY 300 SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY Sbjct: 243 SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY 302 Query: 301 GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF 360 GMDSRPPMAIFELLDYIVNEPPPKLPS VFSLEFQDFVNKCLIKNPAERADLKQLMVHAF Sbjct: 303 GMDSRPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF 362 Query: 361 IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV 393 IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV Sbjct: 363 IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV 395 >3EQC-A nrPDB Length = 360 Score = 498 bits (1283), Expect = e-141, Method: Composition-based stats. Identities = 356/359 (99%), Positives = 358/359 (99%) Query: 35 KKLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVM 94 KKLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVM Sbjct: 2 KKLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVM 61 Query: 95 ARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQV 154 ARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQV Sbjct: 62 ARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQV 121 Query: 155 LKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQ 214 LKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQ Sbjct: 122 LKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQ 181 Query: 215 LIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELM 274 LIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELM Sbjct: 182 LIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELM 241 Query: 275 FGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEF 334 FGCQVEGDAAETPPRPRTPGRPL+ +GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEF Sbjct: 242 FGCQVEGDAAETPPRPRTPGRPLNKFGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEF 301 Query: 335 QDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV 393 QDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV Sbjct: 302 QDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV 360 >1S9I-A nrPDB Length = 354 Score = 422 bits (1084), Expect = e-118, Method: Composition-based stats. Identities = 294/345 (85%), Positives = 314/345 (91%), Gaps = 4/345 (1%) Query: 51 EAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQ 110 EAFLTQK KVGELKDDDFE+ISELGAGNGGVV KV H+PSGL+MARKLIHLEIKPAIRNQ Sbjct: 1 EAFLTQKAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQ 60 Query: 111 IIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVS 170 IIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLK+A RIPE+ILGKVS Sbjct: 61 IIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVS 120 Query: 171 IAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYM 230 IAV++GL YLREKH+IMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYM Sbjct: 121 IAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYM 180 Query: 231 SPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQV----EGDAAET 286 +PERLQGTHYSVQSDIWSMGLSLVE+AVGRYPIPPPDAKELE +FG V EG+ Sbjct: 181 APERLQGTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSI 240 Query: 287 PPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNP 346 PRPR PGRP+S +GMDSRP MAIFELLDYIVNEPPPKLP+GVF+ +FQ+FVNKCLIKNP Sbjct: 241 SPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNP 300 Query: 347 AERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHAA 391 AERADLK L H FIKRS+ EEVDFAGWLC T+ LNQP TPT A Sbjct: 301 AERADLKMLTNHTFIKRSEVEEVDFAGWLCKTLRLNQPGTPTRTA 345 >4AN9-A nrPDB Length = 301 Score = 397 bits (1021), Expect = e-111, Method: Composition-based stats. Identities = 287/335 (85%), Positives = 288/335 (85%), Gaps = 42/335 (12%) Query: 58 QKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQV 117 +GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQV Sbjct: 1 MALGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQV 60 Query: 118 LHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGL 177 LHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGL Sbjct: 61 LHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGL 120 Query: 178 TYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQG 237 TYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID MAN FVGTRSYMSPERLQG Sbjct: 121 TYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDEMANEFVGTRSYMSPERLQG 180 Query: 238 THYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPL 297 THYSVQSDIWSMGLSLVEMAVGRYP Sbjct: 181 THYSVQSDIWSMGLSLVEMAVGRYP----------------------------------- 205 Query: 298 SSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMV 357 RPPMAIFELLDYIVNEPPPKLPS VFSLEFQDFVNKCLIKNPAERADLKQLMV Sbjct: 206 -------RPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFVNKCLIKNPAERADLKQLMV 258 Query: 358 HAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAG 392 HAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAG Sbjct: 259 HAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAG 293 >3COM-A nrPDB Length = 314 Score = 288 bits (738), Expect = 2e-78, Method: Composition-based stats. Identities = 102/331 (30%), Positives = 177/331 (53%), Gaps = 50/331 (15%) Query: 37 LEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMAR 96 LE ++L R++L+ + + + ++ F+ + +LG G+ G V+K HK +G ++A Sbjct: 2 LETVQLRNPPRRQLKKL--DEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAI 59 Query: 97 KLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLK 156 K + +E +II+E+ ++ +C+SP++V +YG+++ + ++ I ME+ GS+ +++ Sbjct: 60 KQVPVESD---LQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIR 116 Query: 157 -KAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL 215 + + E + + + +KGL YL KI HRD+K NIL+N+ G KL DFGV+GQL Sbjct: 117 LRNKTLTEDEIATILQSTLKGLEYLHFMRKI-HRDIKAGNILLNTEGHAKLADFGVAGQL 175 Query: 216 IDSMA--NSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELEL 273 D+MA N+ +GT +M+PE +Q Y+ +DIWS+G++ +EMA G+ P Sbjct: 176 TDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPY---------- 225 Query: 274 MFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLE 333 D P AIF + N PP ++S Sbjct: 226 ----------------------------ADIHPMRAIFMIP---TNPPPTFRKPELWSDN 254 Query: 334 FQDFVNKCLIKNPAERADLKQLMVHAFIKRS 364 F DFV +CL+K+P +RA QL+ H F++ + Sbjct: 255 FTDFVKQCLVKSPEQRATATQLLQHPFVRSA 285 >4LG4-A nrPDB Length = 299 Score = 278 bits (710), Expect = 4e-75, Method: Composition-based stats. Identities = 104/313 (33%), Positives = 168/313 (53%), Gaps = 48/313 (15%) Query: 57 KQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQ 116 + + + ++ F+ + +LG G+ G VFK HK SG V+A K + +E +II+E+ Sbjct: 2 EDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESD---LQEIIKEIS 58 Query: 117 VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLK-KAGRIPEQILGKVSIAVIK 175 ++ +C+SPY+V +YG+++ + ++ I ME+ GS+ +++ + + E + + + +K Sbjct: 59 IMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLK 118 Query: 176 GLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA--NSFVGTRSYMSPE 233 GL YL KI HR++K NIL+N+ G KL DFGV+GQL D+MA N+ +GT +M+PE Sbjct: 119 GLEYLHFMRKI-HRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPE 177 Query: 234 RLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTP 293 +Q Y+ +DIWS+G++ +EMA G+ P Sbjct: 178 VIQEIGYNCVADIWSLGITSIEMAEGKPPY------------------------------ 207 Query: 294 GRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLK 353 D P AIF + N PP ++S +F DFV KCL+KNP +RA Sbjct: 208 --------ADIHPMRAIFMIP---TNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATAT 256 Query: 354 QLMVHAFIKRSDA 366 QL+ H FIK + Sbjct: 257 QLLQHPFIKNAKP 269 >6AO5-A nrPDB Length = 362 Score = 275 bits (702), Expect = 3e-74, Method: Composition-based stats. Identities = 104/313 (33%), Positives = 168/313 (53%), Gaps = 48/313 (15%) Query: 57 KQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQ 116 + + + ++ F+ + +LG G+ G VFK HK SG V+A K + +E +II+E+ Sbjct: 1 EDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESD---LQEIIKEIS 57 Query: 117 VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLK-KAGRIPEQILGKVSIAVIK 175 ++ +C+SPY+V +YG+++ + ++ I ME+ GS+ +++ + + E + + + +K Sbjct: 58 IMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLK 117 Query: 176 GLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA--NSFVGTRSYMSPE 233 GL YL KI HR++K NIL+N+ G KL DFGV+GQL D+MA N+ +GT +M+PE Sbjct: 118 GLEYLHFMRKI-HRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPE 176 Query: 234 RLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTP 293 +Q Y+ +DIWS+G++ +EMA G+ P Sbjct: 177 VIQEIGYNCVADIWSLGITSIEMAEGKPPY------------------------------ 206 Query: 294 GRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLK 353 D P AIF + N PP ++S +F DFV KCL+KNP +RA Sbjct: 207 --------ADIHPMRAIFMIP---TNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATAT 255 Query: 354 QLMVHAFIKRSDA 366 QL+ H FIK + Sbjct: 256 QLLQHPFIKNAKP 268 >4KRC-A nrPDB Length = 317 Score = 273 bits (699), Expect = 8e-74, Method: Composition-based stats. Identities = 82/307 (26%), Positives = 144/307 (46%), Gaps = 21/307 (6%) Query: 67 DFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYI 126 F+++ +LG G V+K +K +G+ +A K + L+ + + IRE+ ++ E I Sbjct: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENI 65 Query: 127 VGFYGAFYSDGEISICMEHMDGGSLDQVLKKA------GRIPEQILGKVSIAVIKGLTYL 180 V Y +++ ++++ E MD L + + + ++ +++GL + Sbjct: 66 VRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFC 124 Query: 181 REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQ--LIDSMANSFVGTRSYMSPERLQGT 238 E +KI+HRD+KP N+L+N RG++KL DFG++ + + +S V T Y +P+ L G+ Sbjct: 125 HE-NKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGS 183 Query: 239 H-YSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPL 297 YS DIWS G L EM G+ P + +E +L + G E+ P P Sbjct: 184 RTYSTSIDIWSCGCILAEMITGKPLFPGTNDEE-QLKLIFDIMGTPNES-LWPSVTKLPK 241 Query: 298 SSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMV 357 + + RPP + ++L EP DF++ L NP R KQ + Sbjct: 242 YNPNIQQRPPRDLRQVLQPHTKEP--------LDGNLMDFLHGLLQLNPDMRLSAKQALH 293 Query: 358 HAFIKRS 364 H + Sbjct: 294 HPWFAEY 300 >3NCG-A nrPDB Length = 486 Score = 272 bits (695), Expect = 2e-73, Method: Composition-based stats. Identities = 77/307 (25%), Positives = 129/307 (42%), Gaps = 47/307 (15%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHL-EIKPAIRNQIIRELQVLHECNSP 124 + + + LG G+ G V K + + A K+I+ K + I+RE+++L + + P Sbjct: 22 ERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKLDHP 81 Query: 125 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKH 184 I+ + I E GG L + K R E ++ V G+TY+ KH Sbjct: 82 NIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMH-KH 140 Query: 185 KIMHRDVKPSNILVNS---RGEIKLCDFGVSGQL-IDSMANSFVGTRSYMSPERLQGTHY 240 I+HRD+KP NIL+ S +IK+ DFG+S ++ +GT Y++PE L+GT Y Sbjct: 141 NIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVLRGT-Y 199 Query: 241 SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY 300 + D+WS G+ L + G P Y Sbjct: 200 DEKCDVWSAGVILYILLSGTPPF------------------------------------Y 223 Query: 301 GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF 360 G + + E Y + P + S + +D + K L +P+ R Q + H + Sbjct: 224 GKNEYDILKRVETGKYAFDLPQWR----TISDDAKDLIRKMLTFHPSLRITATQCLEHPW 279 Query: 361 IKRSDAE 367 I++ +E Sbjct: 280 IQKYSSE 286 >3DFA-A nrPDB Length = 286 Score = 272 bits (695), Expect = 2e-73, Method: Composition-based stats. Identities = 77/307 (25%), Positives = 129/307 (42%), Gaps = 47/307 (15%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHL-EIKPAIRNQIIRELQVLHECNSP 124 + + + LG G+ G V K + + A K+I+ K + I+RE+++L + + P Sbjct: 22 ERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKLDHP 81 Query: 125 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKH 184 I+ + I E GG L + K R E ++ V G+TY+ KH Sbjct: 82 NIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMH-KH 140 Query: 185 KIMHRDVKPSNILVNS---RGEIKLCDFGVSGQL-IDSMANSFVGTRSYMSPERLQGTHY 240 I+HRD+KP NIL+ S +IK+ DFG+S ++ +GT Y++PE L+GT Y Sbjct: 141 NIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVLRGT-Y 199 Query: 241 SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY 300 + D+WS G+ L + G P Y Sbjct: 200 DEKCDVWSAGVILYILLSGTPPF------------------------------------Y 223 Query: 301 GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF 360 G + + E Y + P + S + +D + K L +P+ R Q + H + Sbjct: 224 GKNEYDILKRVETGKYAFDLPQWR----TISDDAKDLIRKMLTFHPSLRITATQCLEHPW 279 Query: 361 IKRSDAE 367 I++ +E Sbjct: 280 IQKYSSE 286 >2BPM-A nrPDB Length = 309 Score = 271 bits (694), Expect = 3e-73, Method: Composition-based stats. Identities = 82/309 (26%), Positives = 141/309 (45%), Gaps = 23/309 (7%) Query: 63 LKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIK-PAIRNQIIRELQVLHEC 121 + ++F+K+ ++G G GVV+K +K +G V+A K I L+ + + + IRE+ +L E Sbjct: 4 VDMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKEL 63 Query: 122 NSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKA--GRIPEQILGKVSIAVIKGLTY 179 N P IV +++ ++ + E + L + + + IP ++ +++GL + Sbjct: 64 NHPNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAF 122 Query: 180 LREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL--IDSMANSFVGTRSYMSPERLQG 237 H+++HRD+KP N+L+N+ G IKL DFG++ V T Y +PE L G Sbjct: 123 CHS-HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLG 181 Query: 238 TH-YSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRP 296 YS DIWS+G EM R P D++ +L + G TP PG Sbjct: 182 CKYYSTAVDIWSLGCIFAEMVTRRALFPG-DSEIDQLFRIFRTLG----TPDEVVWPGVT 236 Query: 297 LSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLM 356 S P A + + PP + + +++ L +P +R K + Sbjct: 237 SMPDYKPSFPKWARQDFSKVV----PP------LDEDGRSLLSQMLHYDPNKRISAKAAL 286 Query: 357 VHAFIKRSD 365 H F + Sbjct: 287 AHPFFQDVT 295 >2XIK-A nrPDB Length = 294 Score = 268 bits (685), Expect = 3e-72, Method: Composition-based stats. Identities = 102/318 (32%), Positives = 160/318 (50%), Gaps = 49/318 (15%) Query: 50 LEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRN 109 L F Q +V ++ F K+ +G G+ G V+K + V+A K+I LE Sbjct: 5 LRGFANQHSRVD--PEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIE 62 Query: 110 QIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKV 169 I +E+ VL +C+SPYI ++G++ ++ I ME++ GGS +LK G + E + + Sbjct: 63 DIQQEITVLSQCDSPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLK-PGPLEETYIATI 121 Query: 170 SIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSM--ANSFVGTR 227 ++KGL YL + KI HRD+K +N+L++ +G++KL DFGV+GQL D+ N+FVGT Sbjct: 122 LREILKGLDYLHSERKI-HRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTP 180 Query: 228 SYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETP 287 +M+PE ++ + Y ++DIWS+G++ +E+A G P Sbjct: 181 FWMAPEVIKQSAYDFKADIWSLGITAIELAKGEPP------------------------- 215 Query: 288 PRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPA 347 D P +F I PP L G S F++FV CL K+P Sbjct: 216 -------------NSDLHPMRVLF----LIPKNSPPTL-EGQHSKPFKEFVEACLNKDPR 257 Query: 348 ERADLKQLMVHAFIKRSD 365 R K+L+ H FI R Sbjct: 258 FRPTAKELLKHKFITRYT 275 >4MVF-A nrPDB Length = 506 Score = 268 bits (684), Expect = 4e-72, Method: Composition-based stats. Identities = 72/321 (22%), Positives = 125/321 (38%), Gaps = 49/321 (15%) Query: 65 DDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSP 124 +D + +LG G G V+K K + + A K + I N+ +E++++ + + P Sbjct: 56 EDKYIIDEKLGQGTYGCVYKGIDKVTNQLYAIKEEKKDRLKNI-NRFFQEIEIMKKLDHP 114 Query: 125 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKH 184 IV Y + +D I + ME G L + + G E+ + + + YL + Sbjct: 115 NIVKLYETYENDNYIYLIMELCSGRELFDSIIENGSFTEKNAATIMKQIFSAIFYLHSLN 174 Query: 185 KIMHRDVKPSNILV---NSRGEIKLCDFGVSGQL-IDSMANSFVGTRSYMSPERLQGTHY 240 I+HRD+KP N L N +K+ DFG+S L + GT Y++P+ L G Y Sbjct: 175 -IVHRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFTTTKAGTPYYVAPQVLDG-KY 232 Query: 241 SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY 300 + DIWS G+ + + G P E+ + Y Sbjct: 233 DKKCDIWSSGVIMYTLLCGYPPFYGDTDNEV-----------------LKKVKKGEFCFY 275 Query: 301 GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF 360 D G S + ++ + K L NP ER +++ + H + Sbjct: 276 ENDW-----------------------GSISSDAKNLITKLLTYNPNERCTIEEALNHPW 312 Query: 361 IKRSDA--EEVDFAGWLCSTI 379 I + E V+ + L + Sbjct: 313 ITQMTKSHEHVELSSTLLKNL 333 >6GU6-A nrPDB Length = 302 Score = 266 bits (681), Expect = 9e-72, Method: Composition-based stats. Identities = 83/309 (26%), Positives = 140/309 (45%), Gaps = 24/309 (7%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPA-IRNQIIRELQVLHECNSP 124 +D+ KI ++G G GVV+K HK +G V+A K I LE + + + IRE+ +L E P Sbjct: 7 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 66 Query: 125 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKK---AGRIPEQILGKVSIAVIKGLTYLR 181 IV D + + E + L + L + ++ +++G+ + Sbjct: 67 NIVSLQDVLMQDSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 125 Query: 182 EKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQ--LIDSMANSFVGTRSYMSPERLQGT- 238 + +++HRD+KP N+L++ +G IKL DFG++ + + V T Y SPE L G+ Sbjct: 126 SR-RVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSA 184 Query: 239 HYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLS 298 YS DIWS+G E+A + P+ D++ +L + G TP P Sbjct: 185 RYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALG----TPNNEVWPEVESL 239 Query: 299 SYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVH 358 ++ P L ++ N L D ++K LI +PA+R K + H Sbjct: 240 QDYKNTFPKWKPGSLASHVKNLDENGL----------DLLSKMLIYDPAKRISGKMALNH 289 Query: 359 AFIKRSDAE 367 + D + Sbjct: 290 PYFNDLDNQ 298 >5JN2-A nrPDB Length = 525 Score = 265 bits (678), Expect = 2e-71, Method: Composition-based stats. Identities = 74/315 (23%), Positives = 126/315 (40%), Gaps = 48/315 (15%) Query: 63 LKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE--IKPAIRNQIIRELQVLHE 120 + D ++ LG G+ G V K +G A K+I + + ++RE+Q+L + Sbjct: 64 IFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQ 123 Query: 121 CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL 180 + P I+ Y F G + E GG L + R E ++ V+ G+TY+ Sbjct: 124 LDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYM 183 Query: 181 REKHKIMHRDVKPSNILV---NSRGEIKLCDFGVSGQLI-DSMANSFVGTRSYMSPERLQ 236 K+KI+HRD+KP N+L+ + I++ DFG+S +GT Y++PE L Sbjct: 184 H-KNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVLH 242 Query: 237 GTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRP 296 GT Y + D+WS G+ L + G P A E +++ + E P + Sbjct: 243 GT-YDEKCDVWSTGVILYILLSGCPPFNG--ANEYDILKKVEKGKYTFELPQWKK----- 294 Query: 297 LSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLM 356 S +D + K L P+ R + + Sbjct: 295 ---------------------------------VSESAKDLIRKMLTYVPSMRISARDAL 321 Query: 357 VHAFIKRSDAEEVDF 371 H +I+ E++ Sbjct: 322 DHEWIQTYTKEQISV 336 >3NIZ-A nrPDB Length = 311 Score = 265 bits (678), Expect = 2e-71, Method: Composition-based stats. Identities = 82/308 (26%), Positives = 141/308 (45%), Gaps = 24/308 (7%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEI-KPAIRNQIIRELQVLHECNSP 124 + ++K+ ++G G GVV+K G ++A K I L+ I + IRE+ +L E + P Sbjct: 21 EKYQKLEKVGEGTYGVVYKAKDSQ-GRIVALKRIRLDAEDEGIPSTAIREISLLKELHHP 79 Query: 125 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR-IPEQILGKVSIAVIKGLTYLREK 183 IV +S+ +++ E M+ L +VL + + + + +++G+ + + Sbjct: 80 NIVSLIDVIHSERCLTLVFEFMEK-DLKKVLDENKTGLQDSQIKIYLYQLLRGVAHCH-Q 137 Query: 184 HKIMHRDVKPSNILVNSRGEIKLCDFGVSGQ--LIDSMANSFVGTRSYMSPERLQG-THY 240 H+I+HRD+KP N+L+NS G +KL DFG++ + V T Y +P+ L G Y Sbjct: 138 HRILHRDLKPQNLLINSDGALKLADFGLARAFGIPVRSYTHEVVTLWYRAPDVLMGSKKY 197 Query: 241 SVQSDIWSMGLSLVEMAVGRYPIPP-PDAKELELMFGCQVEGDAAETPPRPRTPGRPLSS 299 S DIWS+G EM G+ P D +L +F + E P P Sbjct: 198 STSVDIWSIGCIFAEMITGKPLFPGVTDDDQLPKIFSILGTPNPREWPQVQELP------ 251 Query: 300 YGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHA 359 + + +FE +P + G F E D ++ L +P +R + M H Sbjct: 252 --LWKQRTFQVFE------KKPWSSIIPG-FCQEGIDLLSNMLCFDPNKRISARDAMNHP 302 Query: 360 FIKRSDAE 367 + K D + Sbjct: 303 YFKDLDPQ 310 >4AGU-A nrPDB Length = 311 Score = 265 bits (676), Expect = 4e-71, Method: Composition-based stats. Identities = 80/302 (26%), Positives = 137/302 (45%), Gaps = 18/302 (5%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARK-LIHLEIKPAIRNQIIRELQVLHECNSP 124 + +EKI ++G G+ GVVFK ++ +G ++A K + E P I+ +RE+++L + P Sbjct: 3 EKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKHP 62 Query: 125 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKH 184 +V F + + E+ D L ++ + +PE ++ ++ ++ + + KH Sbjct: 63 NLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFCH-KH 121 Query: 185 KIMHRDVKPSNILVNSRGEIKLCDFGVSGQLI--DSMANSFVGTRSYMSPERLQG-THYS 241 +HRDVKP NIL+ IKLCDFG + L + V TR Y SPE L G T Y Sbjct: 122 NCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYDDEVATRWYRSPELLVGDTQYG 181 Query: 242 VQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYG 301 D+W++G E+ G P+ P + +L + GD + + + S Sbjct: 182 PPVDVWAIGCVFAELLSG-VPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFSGVK 240 Query: 302 MDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFI 361 + M EL ++ P + CL +P ER +QL+ H + Sbjct: 241 IPDPEDMEPLELKFPNISYP------------ALGLLKGCLHMDPTERLTCEQLLHHPYF 288 Query: 362 KR 363 + Sbjct: 289 EN 290 >4IC8-A nrPDB Length = 442 Score = 264 bits (674), Expect = 5e-71, Method: Composition-based stats. Identities = 80/377 (21%), Positives = 143/377 (37%), Gaps = 54/377 (14%) Query: 6 PTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELKD 65 P P++ PA ++V A NL L+ + ++ D VG Sbjct: 20 PGPVKAEPAHTAASV-----AAKNLALLKARSFDVTFD----------------VG---- 54 Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIR-NQIIRELQVLHECNSP 124 D++E I +G G GVV + +G +A K I + +REL++L Sbjct: 55 DEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHD 114 Query: 125 YIVGFYGAFY------SDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLT 178 I+ + + ++ M+ L Q++ + + + + +++GL Sbjct: 115 NIIAIKDILRPTVPYGEFKSVYVVLDLMES-DLHQIIHSSQPLTLEHVRYFLYQLLRGLK 173 Query: 179 YLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL------IDSMANSFVGTRSYMSP 232 Y+ +++HRD+KPSN+LVN E+K+ DFG++ L +V TR Y +P Sbjct: 174 YMHSA-QVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAP 232 Query: 233 ERLQG-THYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPR 291 E + Y+ D+WS+G EM R P + +L V G +P + Sbjct: 233 ELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNY-VHQLQLIMMVLG--TPSPAVIQ 289 Query: 292 TPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERAD 351 G + S PP P + + + + L P+ R Sbjct: 290 AVGAERVRAYIQSLPPRQPV----------PWETVYPGADRQALSLLGRMLRFEPSARIS 339 Query: 352 LKQLMVHAFIKRSDAEE 368 + H F+ + + Sbjct: 340 AAAALRHPFLAKYHDPD 356 >2VN9-A nrPDB Length = 301 Score = 264 bits (674), Expect = 6e-71, Method: Composition-based stats. Identities = 67/304 (22%), Positives = 121/304 (39%), Gaps = 47/304 (15%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIH-LEIKPAIRNQIIRELQVLHECNSP 124 D+++ ELG G VV + P+G A K+I+ ++ ++ RE ++ P Sbjct: 4 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 63 Query: 125 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKH 184 IV + + +G + + + GG L + + E +++ + + + Sbjct: 64 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCH-LN 122 Query: 185 KIMHRDVKPSNILVNSRGE---IKLCDFGVSGQLIDSMAN--SFVGTRSYMSPERLQGTH 239 I+HRD+KP N+L+ S+ + +KL DFG++ ++ F GT Y+SPE L+ Sbjct: 123 GIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDP 182 Query: 240 YSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSS 299 Y D+W+ G+ L + VG P D L Sbjct: 183 YGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKA---------------------- 220 Query: 300 YGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHA 359 + P P+ + E +D +NK L NPA+R + + H Sbjct: 221 ----------------GAYDFPSPEW--DTVTPEAKDLINKMLTINPAKRITASEALKHP 262 Query: 360 FIKR 363 +I + Sbjct: 263 WICQ 266 >3VN9-A nrPDB Length = 340 Score = 264 bits (674), Expect = 6e-71, Method: Composition-based stats. Identities = 120/340 (35%), Positives = 187/340 (55%), Gaps = 52/340 (15%) Query: 51 EAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQ 110 +A ++ + E+K DD E I ELG G GVV K+ H PSG +MA K I + + + Sbjct: 36 KACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKR 95 Query: 111 IIRELQV-LHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQV----LKKAGRIPEQI 165 ++ +L + + + P+ V FYGA + +G++ ICME MD SLD+ + K IPE I Sbjct: 96 LLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDI 154 Query: 166 LGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSF-V 224 LGK++++++K L +L K ++HRDVKPSN+L+N+ G++K+CDFG+SG L+DS+A + Sbjct: 155 LGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDA 214 Query: 225 GTRSYMSPERL----QGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVE 280 G + YM+PER+ YSV+SDIWS+G++++E+A+ R+P Sbjct: 215 GCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGT------------ 262 Query: 281 GDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNK 340 F+ L +V EP P+LP+ FS EF DF ++ Sbjct: 263 -----------------------------PFQQLKQVVEEPSPQLPADKFSAEFVDFTSQ 293 Query: 341 CLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIG 380 CL KN ER +LM H F +++ D A ++ +G Sbjct: 294 CLKKNSKERPTYPELMQHPFFTLHESKGTDVASFVKLILG 333 >3HZT-A nrPDB Length = 467 Score = 263 bits (672), Expect = 1e-70, Method: Composition-based stats. Identities = 72/302 (23%), Positives = 119/302 (39%), Gaps = 48/302 (15%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRN--QIIRELQVLHECNS 123 D ++++ +LG+G G V K +G A K+I N ++ E+ VL + + Sbjct: 4 DRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDH 63 Query: 124 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREK 183 P I+ Y F + ME GG L + + E + V+ G TYL K Sbjct: 64 PNIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLSGTTYLH-K 122 Query: 184 HKIMHRDVKPSNILVNSRGE---IKLCDFGVSGQL-IDSMANSFVGTRSYMSPERLQGTH 239 H I+HRD+KP N+L+ S+ IK+ DFG+S + +GT Y++PE L+ Sbjct: 123 HNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAPEVLR-KK 181 Query: 240 YSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSS 299 Y + D+WS G+ L + G P +E+ Sbjct: 182 YDEKCDVWSCGVILYILLCGYPPFGGQTDQEI---------------------------- 213 Query: 300 YGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHA 359 + + + PP S E + V L P++R ++ + H Sbjct: 214 ----------LKRVEKGKFSFDPPDWTQ--VSDEAKQLVKLMLTYEPSKRISAEEALNHP 261 Query: 360 FI 361 +I Sbjct: 262 WI 263 >4QMW-A nrPDB Length = 310 Score = 263 bits (671), Expect = 1e-70, Method: Composition-based stats. Identities = 97/303 (32%), Positives = 157/303 (51%), Gaps = 47/303 (15%) Query: 64 KDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNS 123 ++ F K+ ++G G+ G VFK + V+A K+I LE I +E+ VL +C+S Sbjct: 27 PEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDS 86 Query: 124 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREK 183 PY+ +YG++ D ++ I ME++ GGS +L + G + E + + ++KGL YL + Sbjct: 87 PYVTKYYGSYLKDTKLWIIMEYLGGGSALDLL-EPGPLDETQIATILREILKGLDYLHSE 145 Query: 184 HKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSM--ANSFVGTRSYMSPERLQGTHYS 241 KI HRD+K +N+L++ GE+KL DFGV+GQL D+ N+FVGT +M+PE ++ + Y Sbjct: 146 KKI-HRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYD 204 Query: 242 VQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYG 301 ++DIWS+G++ +E+A G P Sbjct: 205 SKADIWSLGITAIELARGEPP--------------------------------------- 225 Query: 302 MDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFI 361 + ++L I PP L G +S ++FV CL K P+ R K+L+ H FI Sbjct: 226 ---HSELHPMKVLFLIPKNNPPTL-EGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFI 281 Query: 362 KRS 364 R+ Sbjct: 282 LRN 284 >3ALO-A nrPDB Length = 327 Score = 263 bits (671), Expect = 1e-70, Method: Composition-based stats. Identities = 122/344 (35%), Positives = 185/344 (53%), Gaps = 57/344 (16%) Query: 59 KVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQV- 117 + + +D + + E+G G G V K+ HKPSG +MA K I + + Q++ +L V Sbjct: 15 QHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVV 74 Query: 118 LHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKA-----GRIPEQILGKVSIA 172 + + PYIV FYGA + +G+ ICME M S D+ K IPE+ILGK+++A Sbjct: 75 MRSSDCPYIVQFYGALFREGDCWICMELMST-SFDKFYKYVYSVLDDVIPEEILGKITLA 133 Query: 173 VIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSF-VGTRSYMS 231 +K L +L+E KI+HRD+KPSNIL++ G IKLCDFG+SGQL+DS+A + G R YM+ Sbjct: 134 TVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMA 193 Query: 232 PERL----QGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETP 287 PER+ Y V+SD+WS+G++L E+A GR+P P ++ Sbjct: 194 PERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNS------------------- 234 Query: 288 PRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSG---VFSLEFQDFVNKCLIK 344 +F+ L +V PP+L + FS F +FVN CL K Sbjct: 235 ----------------------VFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTK 272 Query: 345 NPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQPSTPT 388 + ++R K+L+ H FI + V+ A ++C + P+TP+ Sbjct: 273 DESKRPKYKELLKHPFILMYEERAVEVACYVCKILD-QMPATPS 315 >2BDW-A nrPDB Length = 362 Score = 263 bits (671), Expect = 1e-70, Method: Composition-based stats. Identities = 70/301 (23%), Positives = 127/301 (42%), Gaps = 46/301 (15%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIH-LEIKPAIRNQIIRELQVLHECNSP 124 D+++ ELG G VV + HK +GL A K+I+ ++ ++ RE ++ + P Sbjct: 29 DNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQHP 88 Query: 125 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKH 184 IV + + + + + + GG L + + E +++ + Y + Sbjct: 89 NIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCHS-N 147 Query: 185 KIMHRDVKPSNILVNSRGE---IKLCDFGVSGQLIDSMA-NSFVGTRSYMSPERLQGTHY 240 I+HR++KP N+L+ S+ + +KL DFG++ ++ DS A + F GT Y+SPE L+ Y Sbjct: 148 GIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVLKKDPY 207 Query: 241 SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY 300 S DIW+ G+ L + VG P E + Q++ A + P Sbjct: 208 SKPVDIWACGVILYILLVGYPPFW----DEDQHRLYAQIKAGAYDYP------------- 250 Query: 301 GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF 360 P+ + E + ++ L NP +R Q + + Sbjct: 251 ---------------------SPEW--DTVTPEAKSLIDSMLTVNPKKRITADQALKVPW 287 Query: 361 I 361 I Sbjct: 288 I 288 >3DXN-A nrPDB Length = 287 Score = 262 bits (670), Expect = 2e-70, Method: Composition-based stats. Identities = 72/302 (23%), Positives = 119/302 (39%), Gaps = 48/302 (15%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRN--QIIRELQVLHECNS 123 D ++++ +LG+G G V K +G A K+I N ++ E+ VL + + Sbjct: 21 DRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDH 80 Query: 124 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREK 183 P I+ Y F + ME GG L + + E + V+ G TYL K Sbjct: 81 PNIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLSGTTYLH-K 139 Query: 184 HKIMHRDVKPSNILVNSRGE---IKLCDFGVSGQL-IDSMANSFVGTRSYMSPERLQGTH 239 H I+HRD+KP N+L+ S+ IK+ DFG+S + +GT Y++PE L+ Sbjct: 140 HNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAPEVLR-KK 198 Query: 240 YSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSS 299 Y + D+WS G+ L + G P +E+ Sbjct: 199 YDEKCDVWSCGVILYILLCGYPPFGGQTDQEI---------------------------- 230 Query: 300 YGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHA 359 + + + PP S E + V L P++R ++ + H Sbjct: 231 ----------LKRVEKGKFSFDPPDWTQ--VSDEAKQLVKLMLTYEPSKRISAEEALNHP 278 Query: 360 FI 361 +I Sbjct: 279 WI 280 >5FG8-A nrPDB Length = 285 Score = 262 bits (669), Expect = 2e-70, Method: Composition-based stats. Identities = 64/306 (20%), Positives = 127/306 (41%), Gaps = 47/306 (15%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIR-NQIIRELQVLHECNSP 124 D+++ ELG G +V + K +G A K+I+ + A ++ RE ++ + + P Sbjct: 14 DNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHHP 73 Query: 125 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKH 184 IV + + + + + + GG L + + E +++ + + ++ Sbjct: 74 NIVRLHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCH-QN 132 Query: 185 KIMHRDVKPSNILVNSRGE---IKLCDFGVSGQLIDSMAN--SFVGTRSYMSPERLQGTH 239 ++HRD+KP N+L+ S+ + +KL DFG++ ++ F GT Y+SPE L+ Sbjct: 133 GVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKEP 192 Query: 240 YSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSS 299 Y DIW+ G+ L + VG P E + Q++ A + P Sbjct: 193 YGKSVDIWACGVILYILLVGYPPFW----DEDQHRLYSQIKAGAYDYP------------ 236 Query: 300 YGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHA 359 P+ + E ++ +N+ L NP +R + + H Sbjct: 237 ----------------------SPEW--DTVTPEAKNLINQMLTVNPNKRITAAEALKHP 272 Query: 360 FIKRSD 365 +I + + Sbjct: 273 WICQRE 278 >3FME-A nrPDB Length = 290 Score = 261 bits (668), Expect = 3e-70, Method: Composition-based stats. Identities = 118/329 (35%), Positives = 180/329 (54%), Gaps = 52/329 (15%) Query: 62 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQV-LHE 120 E+K DD E I ELG G GVV K+ H PSG +MA K I + + +++ +L + + Sbjct: 3 EVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRT 62 Query: 121 CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQV----LKKAGRIPEQILGKVSIAVIKG 176 + P+ V FYGA + +G++ ICME MD SLD+ + K IPE ILGK++++++K Sbjct: 63 VDCPFTVTFYGALFREGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVKA 121 Query: 177 LTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSF-VGTRSYMSPERL 235 L +L K ++HRDVKPSN+L+N+ G++K+CDFG+SG L+D +A G + YM+PER+ Sbjct: 122 LEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDDVAKDIDAGCKPYMAPERI 181 Query: 236 ----QGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPR 291 YSV+SDIWS+G++++E+A+ R+P Sbjct: 182 NPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGT----------------------- 218 Query: 292 TPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERAD 351 F+ L +V EP P+LP+ FS EF DF ++CL KN ER Sbjct: 219 ------------------PFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPT 260 Query: 352 LKQLMVHAFIKRSDAEEVDFAGWLCSTIG 380 +LM H F +++ D A ++ +G Sbjct: 261 YPELMQHPFFTLHESKGTDVASFVKLILG 289 >5WAX-A nrPDB Length = 310 Score = 261 bits (668), Expect = 3e-70, Method: Composition-based stats. Identities = 81/324 (25%), Positives = 133/324 (41%), Gaps = 46/324 (14%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPY 125 D +E + ++G+GN GV + ++ G ++A K I E I + RE+ P Sbjct: 11 DRYELVRDIGSGNFGVARLMRNRADGQLVAVKYI--ERGEKIDENVQREIINHRSLRHPN 68 Query: 126 IVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHK 185 I+ F + ++I ME+ GG L + + AGR E +I G++Y + Sbjct: 69 IIRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHSM-Q 127 Query: 186 IMHRDVKPSNILVNSRG--EIKLCDFGVSGQ-LIDSMANSFVGTRSYMSPERLQGTHYSV 242 + HRD+K N L++ +K+CDFG S ++ S S VGT +Y++PE L Y Sbjct: 128 VCHRDLKLENTLLDGSTAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDG 187 Query: 243 QS-DIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYG 301 + D+WS G++L M VG YP PD + ++ G P Sbjct: 188 KVADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRILGVQYSIPDYV----------- 236 Query: 302 MDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFI 361 S E QD +++ + NPA R + ++ H + Sbjct: 237 ---------------------------HISPECQDLISRIFVANPATRITIPEIRNHPWF 269 Query: 362 -KRSDAEEVDFAGWLCSTIGLNQP 384 K A+ +D + QP Sbjct: 270 LKNLPADLMDDSTMSKQYEEPEQP 293 >3KK8-A nrPDB Length = 284 Score = 261 bits (668), Expect = 3e-70, Method: Composition-based stats. Identities = 70/301 (23%), Positives = 127/301 (42%), Gaps = 46/301 (15%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIH-LEIKPAIRNQIIRELQVLHECNSP 124 D+++ ELG G VV + HK +GL A K+I+ ++ ++ RE ++ + P Sbjct: 6 DNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQHP 65 Query: 125 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKH 184 IV + + + + + + GG L + + E +++ + Y + Sbjct: 66 NIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCHS-N 124 Query: 185 KIMHRDVKPSNILVNSRGE---IKLCDFGVSGQLIDSMA-NSFVGTRSYMSPERLQGTHY 240 I+HR++KP N+L+ S+ + +KL DFG++ ++ DS A + F GT Y+SPE L+ Y Sbjct: 125 GIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVLKKDPY 184 Query: 241 SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY 300 S DIW+ G+ L + VG P E + Q++ A + P Sbjct: 185 SKPVDIWACGVILYILLVGYPPFW----DEDQHRLYAQIKAGAYDYP------------- 227 Query: 301 GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF 360 P+ + E + ++ L NP +R Q + + Sbjct: 228 ---------------------SPEW--DTVTPEAKSLIDSMLTVNPKKRITADQALKVPW 264 Query: 361 I 361 I Sbjct: 265 I 265 >4FZF-B nrPDB Length = 283 Score = 261 bits (668), Expect = 3e-70, Method: Composition-based stats. Identities = 96/300 (32%), Positives = 155/300 (51%), Gaps = 47/300 (15%) Query: 64 KDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNS 123 ++ F K+ +G G+ G VFK + V+A K+I LE I +E+ VL +C+S Sbjct: 6 PEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDS 65 Query: 124 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREK 183 Y+ +YG++ ++ I ME++ GGS +L+ AG E + + ++KGL YL + Sbjct: 66 SYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLR-AGPFDEFQIATMLKEILKGLDYLHSE 124 Query: 184 HKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSM--ANSFVGTRSYMSPERLQGTHYS 241 KI HRD+K +N+L++ +G++KL FGV+GQL D+ N+FVGT +M+PE +Q + Y Sbjct: 125 KKI-HRDIKAANVLLSEQGDVKLAAFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYD 183 Query: 242 VQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYG 301 ++DIWS+G++ +E+A G P Sbjct: 184 SKADIWSLGITAIELAKGEPP--------------------------------------N 205 Query: 302 MDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFI 361 D P +F I PP L G F+ F++F++ CL K+P+ R K+L+ H FI Sbjct: 206 SDMHPMRVLF----LIPKNNPPTLV-GDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFI 260 >2V7O-A nrPDB Length = 336 Score = 261 bits (667), Expect = 3e-70, Method: Composition-based stats. Identities = 69/319 (21%), Positives = 124/319 (38%), Gaps = 47/319 (14%) Query: 51 EAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIH-LEIKPAIRN 109 E Q DD++ ELG G VV + K A K+I+ ++ Sbjct: 16 ENLYFQSMATCTRFTDDYQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSARDHQ 75 Query: 110 QIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKV 169 ++ RE ++ P IV + + +G + + + GG L + + E Sbjct: 76 KLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHC 135 Query: 170 SIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGE---IKLCDFGVSGQLIDSMAN--SFV 224 +++ + ++ +H I+HRD+KP N+L+ S+ + +KL DFG++ ++ F Sbjct: 136 IHQILESVNHIH-QHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFA 194 Query: 225 GTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAA 284 GT Y+SPE L+ Y DIW+ G+ L + VG P D +L Sbjct: 195 GTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKA------- 247 Query: 285 ETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIK 344 + P P+ + E ++ +N+ L Sbjct: 248 -------------------------------GAYDFPSPEW--DTVTPEAKNLINQMLTI 274 Query: 345 NPAERADLKQLMVHAFIKR 363 NPA+R Q + H ++ + Sbjct: 275 NPAKRITADQALKHPWVCQ 293 >3MA6-A nrPDB Length = 298 Score = 261 bits (666), Expect = 5e-70, Method: Composition-based stats. Identities = 74/312 (23%), Positives = 125/312 (40%), Gaps = 48/312 (15%) Query: 63 LKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE--IKPAIRNQIIRELQVLHE 120 + D ++ LG G+ G V K +G A K+I + + ++RE+Q+L + Sbjct: 29 IFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQ 88 Query: 121 CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL 180 + P I+ Y F G + E GG L + R E ++ V+ G+TY+ Sbjct: 89 LDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYM 148 Query: 181 REKHKIMHRDVKPSNILV---NSRGEIKLCDFGVSGQLI-DSMANSFVGTRSYMSPERLQ 236 K+KI+HRD+KP N+L+ + I++ DFG+S +GT Y++PE L Sbjct: 149 H-KNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVLH 207 Query: 237 GTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRP 296 GT Y + D+WS G+ L + G P A E +++ + E P + Sbjct: 208 GT-YDEKCDVWSTGVILYILLSGCPPFNG--ANEYDILKKVEKGKYTFELPQWKK----- 259 Query: 297 LSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLM 356 S +D + K L P+ R + + Sbjct: 260 ---------------------------------VSESAKDLIRKMLTYVPSMRISARDAL 286 Query: 357 VHAFIKRSDAEE 368 H +I+ E+ Sbjct: 287 DHEWIQTYTKEQ 298 >4REW-A nrPDB Length = 540 Score = 260 bits (664), Expect = 9e-70, Method: Composition-based stats. Identities = 71/311 (22%), Positives = 129/311 (41%), Gaps = 49/311 (15%) Query: 61 GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIR--NQIIRELQVL 118 G +K + LG G G V H+ +G +A K+++ + ++ +I RE+Q L Sbjct: 1 GSVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNL 60 Query: 119 HECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLT 178 P+I+ Y + +I + ME++ GG L + K GR+ E+ ++ ++ G+ Sbjct: 61 KLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVD 120 Query: 179 YLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID-SMANSFVGTRSYMSPERLQG 237 Y +H ++HRD+KP N+L+++ K+ DFG+S + D + G+ +Y +PE + G Sbjct: 121 YCH-RHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISG 179 Query: 238 THY-SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRP 296 Y + DIWS G+ L + G P Sbjct: 180 RLYAGPEVDIWSSGVILYALLCGTLPFD-------------------------------- 207 Query: 297 LSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLM 356 D P ++ D I P + + L +P +RA +K + Sbjct: 208 ------DDHVPTLFKKICDGIFYTP------QYLNPSVISLLKHMLQVDPMKRASIKDIR 255 Query: 357 VHAFIKRSDAE 367 H + K+ + Sbjct: 256 EHEWFKQDLPK 266 >5IG1-A nrPDB Length = 344 Score = 259 bits (663), Expect = 1e-69, Method: Composition-based stats. Identities = 69/310 (22%), Positives = 125/310 (40%), Gaps = 47/310 (15%) Query: 62 ELKDDDFEKIS-ELGAGNGGVVFKVSHKPSGLVMARKLIHLE-IKPAIRNQIIRELQVLH 119 +L D D + +G G V + +K +G V A K+I L+ ++ + N+I RE+ + Sbjct: 12 DLYDVDLKDKRSVIGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRSSEINKIKREIGICS 71 Query: 120 ECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTY 179 +IV AF + + E++ GG L + E+ ++ L + Sbjct: 72 SLQHEHIVSMRRAFRDESHFYLVFEYVSGGELFDEIVTRKFYNEKDASACMHQILSALQH 131 Query: 180 LREKHKIMHRDVKPSNILV---NSRGEIKLCDFGVSGQLIDSMAN-SFVGTRSYMSPERL 235 K+ I+HRD+KP N+L+ + +K+ DFG++ + F GT Y+SPE + Sbjct: 132 CHSKN-IIHRDLKPENLLLASKDPNAPVKITDFGLAVIMEQGPTYFGFAGTPGYLSPEVI 190 Query: 236 QGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGR 295 + Y D+W+ G+ L + VG P D ++L Sbjct: 191 RRVPYDTAVDVWACGVILYILLVGYPPFWEEDHQKLYAQIK------------------- 231 Query: 296 PLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQL 355 + + P P+ S + ++ + L NP R +++L Sbjct: 232 -------------------NCQYDFPSPEWDS--VTTAAKELIKAMLEPNPKRRPTVQEL 270 Query: 356 MVHAFIKRSD 365 + H +I R D Sbjct: 271 LQHPWIARRD 280 >4C0T-A nrPDB Length = 974 Score = 259 bits (663), Expect = 1e-69, Method: Composition-based stats. Identities = 84/382 (21%), Positives = 152/382 (39%), Gaps = 67/382 (17%) Query: 16 DGSAVNGTSSAETNLEALQ-KKLEELELDEQQR-KRLEAFLTQKQKVGELKD-----DDF 68 + V+ T E N + + K E L+ +E+ K+ A T K GE+K DF Sbjct: 209 SNNTVDNTEEEENNDDTDEIPKSETLKQNEENWEKKGAAVKTIKTMDGEMKTIRRNVTDF 268 Query: 69 EKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE--IKPAIRNQIIRELQVLHECNSP-Y 125 + ELG G+ V + K +G A K++ IK + E L+ ++ Sbjct: 269 KFGKELGEGSYSTVILATDKITGKQYAVKVLDKRHIIKEKKVKYVNIEKHALNRLSNRLG 328 Query: 126 IVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHK 185 ++ Y F + +++ G L ++K+ + E+ ++ + Y+ + + Sbjct: 329 VISLYFTFQDKDSLYFVLDYASNGELLTLIKRYNTLNEECTRHFGAQILDAIKYMHD-NG 387 Query: 186 IMHRDVKPSNILVNSRGEIKLCDFGVSGQL-----------IDSMANSFVGTRSYMSPER 234 ++HRD+KP NIL++ + I++ DFG + L +D A SFVGT Y+SPE Sbjct: 388 VIHRDLKPENILLDDKMRIQITDFGTARLLEKKNDESEEYPVDVRAKSFVGTAEYVSPEL 447 Query: 235 LQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPG 294 L+ + D+W+ G + +M G+ P Sbjct: 448 LENKYCGKPGDVWAFGCIIYQMIAGKPPF------------------------------- 476 Query: 295 RPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQ 354 + + Y + F S F +D + K L+ P+ RA + + Sbjct: 477 KATNEYLTFQKITKLQFAF-------------SAGFPTIIRDLIKKILVLQPSRRATIPE 523 Query: 355 LMVHAFIKRSDAEEVDFAGWLC 376 + H F + D ++ D + WL Sbjct: 524 IQKHYFFQSVDFKDFD-SIWLS 544 >3DAK-A nrPDB Length = 290 Score = 259 bits (663), Expect = 1e-69, Method: Composition-based stats. Identities = 87/328 (26%), Positives = 149/328 (45%), Gaps = 67/328 (20%) Query: 61 GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE 120 + DD+E +G+G VV P +A K I+LE +++++E+Q + + Sbjct: 5 WSINRDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQ 64 Query: 121 CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLK--------KAGRIPEQILGKVSIA 172 C+ P IV +Y +F E+ + M+ + GGS+ ++K K+G + E + + Sbjct: 65 CHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILRE 124 Query: 173 VIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL-------IDSMANSFVG 225 V++GL YL K+ +HRDVK NIL+ G +++ DFGVS L + + +FVG Sbjct: 125 VLEGLEYLH-KNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVG 183 Query: 226 TRSYMSPERLQG-THYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAA 284 T +M+PE ++ Y ++DIWS G++ +E+A G P Sbjct: 184 TPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPY--------------------- 222 Query: 285 ETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLE--------FQD 336 PPM + L + PP L +GV E F+ Sbjct: 223 ------------------HKYPPMKVLMLT---LQNDPPSLETGVQDKEMLKKYGKSFRK 261 Query: 337 FVNKCLIKNPAERADLKQLMVHAFIKRS 364 ++ CL K+P +R +L+ H F +++ Sbjct: 262 MISLCLQKDPEKRPTAAELLRHKFFQKA 289 >4FG9-A nrPDB Length = 320 Score = 259 bits (663), Expect = 1e-69, Method: Composition-based stats. Identities = 78/338 (23%), Positives = 131/338 (38%), Gaps = 47/338 (13%) Query: 50 LEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRN 109 L A + K E D ++ LG G V K + ++A K I E Sbjct: 2 LGAVEGPRWKQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEG 61 Query: 110 QIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKV 169 + E+ VLH+ P IV + S G + + M+ + GG L + + G E+ ++ Sbjct: 62 SMENEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRL 121 Query: 170 SIAVIKGLTYLREKHKIMHRDVKPSNIL---VNSRGEIKLCDFGVSG-QLIDSMANSFVG 225 V+ + YL + I+HRD+KP N+L ++ +I + DFG+S + S+ ++ G Sbjct: 122 IFQVLDAVKYLHDL-GIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACG 180 Query: 226 TRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPP-DAKELELMFGCQVEGDAA 284 T Y++PE L YS D WS+G+ + G P DAK E + + E D+ Sbjct: 181 TPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSP 240 Query: 285 ETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIK 344 S +DF+ + K Sbjct: 241 YW-----------------------------------------DDISDSAKDFIRHLMEK 259 Query: 345 NPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLN 382 +P +R +Q + H +I A + + + I N Sbjct: 260 DPEKRFTCEQALQHPWIAGDTALDKNIHQSVSEQIKKN 297 >3LIJ-A nrPDB Length = 494 Score = 259 bits (662), Expect = 1e-69, Method: Composition-based stats. Identities = 74/316 (23%), Positives = 127/316 (40%), Gaps = 48/316 (15%) Query: 54 LTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHL-EIKPAIRNQII 112 + K G L + ++++ +LG+G G V K + + A K+I + + ++++ Sbjct: 26 MFITSKKGHL-SEMYQRVKKLGSGAYGEVLLCRDKVTHVERAIKIIRKTSVSTSSNSKLL 84 Query: 113 RELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIA 172 E+ VL + P I+ Y F + ME GG L + + E + Sbjct: 85 EEVAVLKLLDHPNIMKLYDFFEDKRNYYLVMECYKGGELFDEIIHRMKFNEVDAAVIIKQ 144 Query: 173 VIKGLTYLREKHKIMHRDVKPSNILVNS---RGEIKLCDFGVSGQLID-SMANSFVGTRS 228 V+ G+TYL KH I+HRD+KP N+L+ S IK+ DFG+S + +GT Sbjct: 145 VLSGVTYLH-KHNIVHRDLKPENLLLESKEKDALIKIVDFGLSAVFENQKKMKERLGTAY 203 Query: 229 YMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPP 288 Y++PE L+ Y + D+WS+G+ L + G P +E+ Sbjct: 204 YIAPEVLR-KKYDEKCDVWSIGVILFILLAGYPPFGGQTDQEI----------------- 245 Query: 289 RPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAE 348 + E Y + P K S +D + + L + Sbjct: 246 -------------------LRKVEKGKYTFDSPEWK----NVSEGAKDLIKQMLQFDSQR 282 Query: 349 RADLKQLMVHAFIKRS 364 R +Q + H +IK Sbjct: 283 RISAQQALEHPWIKEM 298 >2JC6-A nrPDB Length = 334 Score = 259 bits (661), Expect = 2e-69, Method: Composition-based stats. Identities = 76/350 (21%), Positives = 132/350 (37%), Gaps = 48/350 (13%) Query: 47 RKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPA 106 R+ E+ + K++ ++K FE LG G V K +G + A K I + Sbjct: 4 RENGESSSSWKKQAEDIKKI-FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKG 62 Query: 107 IRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQIL 166 + I E+ VL + IV + S + + M+ + GG L + + G E+ Sbjct: 63 KESSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDA 122 Query: 167 GKVSIAVIKGLTYLREKHKIMHRDVKPSNILV---NSRGEIKLCDFGVSG-QLIDSMANS 222 + V+ + YL + I+HRD+KP N+L + +I + DFG+S + + ++ Sbjct: 123 STLIRQVLDAVYYLH-RMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMST 181 Query: 223 FVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPP-DAKELELMFGCQVEG 281 GT Y++PE L YS D WS+G+ + G P D+K E + + E Sbjct: 182 ACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEF 241 Query: 282 DAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKC 341 D+ S +DF+ Sbjct: 242 DSPYW-----------------------------------------DDISDSAKDFIRNL 260 Query: 342 LIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHAA 391 + K+P +R +Q H +I A + + + I N + A Sbjct: 261 MEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKNFAKSKWRQA 310 >4CFH-A nrPDB Length = 493 Score = 258 bits (660), Expect = 3e-69, Method: Composition-based stats. Identities = 74/319 (23%), Positives = 134/319 (42%), Gaps = 50/319 (15%) Query: 54 LTQKQKV-GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIR--NQ 110 + +KQK G +K + LG G G V H+ +G +A K+++ + ++ + Sbjct: 20 MAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGK 79 Query: 111 IIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVS 170 I RE+Q L P+I+ Y + +I + ME++ GG L + K GR+ E+ ++ Sbjct: 80 IRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLF 139 Query: 171 IAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID-SMANSFVGTRSY 229 ++ G+ Y +H ++HRD+KP N+L+++ K+ DFG+S + D + G+ +Y Sbjct: 140 QQILSGVDYCH-RHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNY 198 Query: 230 MSPERLQGTHY-SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPP 288 +PE + G Y + DIWS G+ L + G P Sbjct: 199 AAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFD------------------------ 234 Query: 289 RPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAE 348 D P ++ D I P + + L +P + Sbjct: 235 --------------DDHVPTLFKKICDGIFYTP------QYLNPSVISLLKHMLQVDPMK 274 Query: 349 RADLKQLMVHAFIKRSDAE 367 RA +K + H + K+ + Sbjct: 275 RATIKDIREHEWFKQDLPK 293 >4CFF-A nrPDB Length = 571 Score = 258 bits (660), Expect = 3e-69, Method: Composition-based stats. Identities = 76/345 (22%), Positives = 136/345 (39%), Gaps = 63/345 (18%) Query: 54 LTQKQKV-GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIR--NQ 110 + +KQK G +K + LG G G V H+ +G +A K+++ + ++ + Sbjct: 20 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGK 79 Query: 111 IIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVS 170 I RE+Q L P+I+ Y + + + ME++ GG L + K GR+ E ++ Sbjct: 80 IKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLF 139 Query: 171 IAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID-SMANSFVGTRSY 229 ++ + Y +H ++HRD+KP N+L+++ K+ DFG+S + D + G+ +Y Sbjct: 140 QQILSAVDYCH-RHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNY 198 Query: 230 MSPERLQGTHY-SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPP 288 +PE + G Y + DIWS G+ L + G P E ++ G P Sbjct: 199 AAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPF----DDEHVPTLFKKIRGGVFYIPE 254 Query: 289 RPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAE 348 + L +P + Sbjct: 255 YLNRSVAT----------------------------------------LLMHMLQVDPLK 274 Query: 349 RADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV 393 RA +K + H + K+ D +L P P++ A V Sbjct: 275 RATIKDIREHEWFKQ------DLPSYL-------FPEDPSYDANV 306 >5KCV-A nrPDB Length = 460 Score = 258 bits (659), Expect = 3e-69, Method: Composition-based stats. Identities = 76/329 (23%), Positives = 128/329 (38%), Gaps = 55/329 (16%) Query: 43 DEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE 102 D + +E L + + ++FE + LG G G V V K +G A K++ E Sbjct: 141 DNSGAEEMEVSLAK--PKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKE 198 Query: 103 IKPAIRN--QIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR 160 + A + E +VL P++ +F + + ME+ +GG L L + Sbjct: 199 VIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERV 258 Query: 161 IPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS-- 218 E ++ L YL + +++RD+K N++++ G IK+ DFG+ + I Sbjct: 259 FSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGA 318 Query: 219 MANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQ 278 +F GT Y++PE L+ Y D W +G+ + EM GR P D ++L + Sbjct: 319 TMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELI--- 375 Query: 279 VEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFV 338 E PRT G E + + Sbjct: 376 ----LMEEIRFPRTLG-------------------------------------PEAKSLL 394 Query: 339 NKCLIKNPAERA-----DLKQLMVHAFIK 362 + L K+P +R D K++M H F Sbjct: 395 SGLLKKDPKQRLGGGSEDAKEIMQHRFFA 423 >5U6Y-A nrPDB Length = 461 Score = 258 bits (658), Expect = 4e-69, Method: Composition-based stats. Identities = 63/302 (20%), Positives = 117/302 (38%), Gaps = 47/302 (15%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIH-LEIKPAIRNQIIRELQVLHECNSPYI 126 ++ ELG G VV + +G A K+I+ ++ ++ RE ++ P I Sbjct: 2 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 61 Query: 127 VGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKI 186 V + + +G + + + GG L + + E +++ + + + + Sbjct: 62 VRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQM-GV 120 Query: 187 MHRDVKPSNILVNSRGE---IKLCDFGVSGQLIDSMAN--SFVGTRSYMSPERLQGTHYS 241 +HRD+KP N+L+ S+ + +KL DFG++ ++ F GT Y+SPE L+ Y Sbjct: 121 VHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYG 180 Query: 242 VQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYG 301 D+W+ G+ L + VG P D L Sbjct: 181 KPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKA------------------------ 216 Query: 302 MDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFI 361 + P P+ + E +D +NK L NP++R + + H +I Sbjct: 217 --------------GAYDFPSPEW--DTVTPEAKDLINKMLTINPSKRITAAEALKHPWI 260 Query: 362 KR 363 Sbjct: 261 SH 262 >4RED-A nrPDB Length = 351 Score = 258 bits (658), Expect = 5e-69, Method: Composition-based stats. Identities = 71/311 (22%), Positives = 129/311 (41%), Gaps = 49/311 (15%) Query: 61 GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIR--NQIIRELQVL 118 G +K + LG G G V H+ +G +A K+++ + ++ +I RE+Q L Sbjct: 9 GSVKIGHYILGDTLGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLDVVGKIRREIQNL 68 Query: 119 HECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLT 178 P+I+ Y + +I + ME++ GG L + K GR+ E+ ++ ++ G+ Sbjct: 69 KLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVD 128 Query: 179 YLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID-SMANSFVGTRSYMSPERLQG 237 Y +H ++HRD+KP N+L+++ K+ DFG+S + D + G+ +Y +PE + G Sbjct: 129 YCH-RHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISG 187 Query: 238 THY-SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRP 296 Y + DIWS G+ L + G P Sbjct: 188 RLYAGPEVDIWSSGVILYALLCGTLPFD-------------------------------- 215 Query: 297 LSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLM 356 D P ++ D I P + + L +P +RA +K + Sbjct: 216 ------DDHVPTLFKKICDGIFYTP------QYLNPSVISLLKHMLQVDPMKRASIKDIR 263 Query: 357 VHAFIKRSDAE 367 H + K+ + Sbjct: 264 EHEWFKQDLPK 274 >2QNJ-A nrPDB Length = 328 Score = 257 bits (657), Expect = 5e-69, Method: Composition-based stats. Identities = 69/310 (22%), Positives = 132/310 (42%), Gaps = 48/310 (15%) Query: 62 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHL-EIKPAIRNQIIRELQVLHE 120 + ++ + +G GN V H +G +A K+I ++ P ++ RE++++ Sbjct: 8 QPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKI 67 Query: 121 CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL 180 N P IV + ++ + + ME+ GG + L GR+ E+ ++ + Y Sbjct: 68 LNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYC 127 Query: 181 REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL-IDSMANSFVGTRSYMSPERLQGTH 239 +K +I+HRD+K N+L+++ IK+ DFG S + + ++F G+ Y +PE QG Sbjct: 128 HQK-RIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKK 186 Query: 240 YS-VQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLS 298 Y + D+WS+G+ L + G P + KEL Sbjct: 187 YDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELR-------------------------- 220 Query: 299 SYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVH 358 R + + Y+ S + ++ + + L+ NP +R L+Q+M Sbjct: 221 -----ERVLRGKYRIPFYM-------------STDCENLLKRFLVLNPIKRGTLEQIMKD 262 Query: 359 AFIKRSDAEE 368 +I E+ Sbjct: 263 RWINAGHEED 272 >4AU8-A nrPDB Length = 296 Score = 257 bits (657), Expect = 5e-69, Method: Composition-based stats. Identities = 74/308 (24%), Positives = 139/308 (45%), Gaps = 21/308 (6%) Query: 61 GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIK-PAIRNQIIRELQVLH 119 G + +EK+ ++G G G VFK ++ + ++A K + L+ + + +RE+ +L Sbjct: 1 GAMGSQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLK 60 Query: 120 ECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKA-GRIPEQILGKVSIAVIKGLT 178 E IV + +SD ++++ E D L + G + +I+ ++KGL Sbjct: 61 ELKHKNIVRLHDVLHSDKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFLFQLLKGLG 119 Query: 179 YLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQ--LIDSMANSFVGTRSYMSPERLQ 236 + ++ ++HRD+KP N+L+N GE+KL DFG++ + ++ V T Y P+ L Sbjct: 120 FCHSRN-VLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLF 178 Query: 237 GTH-YSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGR 295 G YS D+WS G E+A P+ P + + +L ++ G E + Sbjct: 179 GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEE--------Q 230 Query: 296 PLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQL 355 S + P ++ +VN P +G +D + L NP +R ++ Sbjct: 231 WPSMTKLPDYKPYPMYPATTSLVNVVPKLNATG------RDLLQNLLKCNPVQRISAEEA 284 Query: 356 MVHAFIKR 363 + H + Sbjct: 285 LQHPYFSD 292 >5ES1-A nrPDB Length = 328 Score = 257 bits (657), Expect = 6e-69, Method: Composition-based stats. Identities = 72/307 (23%), Positives = 133/307 (43%), Gaps = 49/307 (15%) Query: 67 DFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHL-EIKPAIRNQIIRELQVLHECNSPY 125 ++ + +G GN V H +G +A K+I ++ P+ ++ RE++++ N P Sbjct: 16 NYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPN 75 Query: 126 IVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHK 185 IV + ++ + + ME+ G + L GR+ E+ ++ + Y +K+ Sbjct: 76 IVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKN- 134 Query: 186 IMHRDVKPSNILVNSRGEIKLCDFGVSGQLI-DSMANSFVGTRSYMSPERLQGTHYS-VQ 243 I+HRD+K N+L+++ IK+ DFG S + S ++F G+ Y +PE QG Y + Sbjct: 135 IVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPE 194 Query: 244 SDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMD 303 DIWS+G+ L + G P + KEL Sbjct: 195 VDIWSLGVILYTLVSGSLPFDGHNLKELR------------------------------- 223 Query: 304 SRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIK- 362 R + + Y+ S + + + + L+ NPA+R L+Q+M +I Sbjct: 224 ERVLRGKYRVPFYM-------------STDCESILRRFLVLNPAKRCTLEQIMKDKWINI 270 Query: 363 RSDAEEV 369 + EE+ Sbjct: 271 GYEGEEL 277 >5EZV-A nrPDB Length = 560 Score = 257 bits (656), Expect = 7e-69, Method: Composition-based stats. Identities = 76/344 (22%), Positives = 135/344 (39%), Gaps = 63/344 (18%) Query: 55 TQKQKV-GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIR--NQI 111 +KQK G +K + LG G G V H+ +G +A K+++ + ++ +I Sbjct: 16 AEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKI 75 Query: 112 IRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSI 171 RE+Q L P+I+ Y + + + ME++ GG L + K GR+ E ++ Sbjct: 76 KREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQ 135 Query: 172 AVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID-SMANSFVGTRSYM 230 ++ + Y +H ++HRD+KP N+L+++ K+ DFG+S + D + G+ +Y Sbjct: 136 QILSAVDYCH-RHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA 194 Query: 231 SPERLQGTHY-SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPR 289 +PE + G Y + DIWS G+ L + G P E ++ G P Sbjct: 195 APEVISGRLYAGPEVDIWSCGVILYALLCGTLPF----DDEHVPTLFKKIRGGVFYIPEY 250 Query: 290 PRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAER 349 + L +P +R Sbjct: 251 LNRSVAT----------------------------------------LLMHMLQVDPLKR 270 Query: 350 ADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV 393 A +K + H + K+ D +L P P++ A V Sbjct: 271 ATIKDIREHEWFKQ------DLPSYL-------FPEDPSYDANV 301 >5XZW-A nrPDB Length = 471 Score = 256 bits (655), Expect = 9e-69, Method: Composition-based stats. Identities = 77/317 (24%), Positives = 120/317 (37%), Gaps = 58/317 (18%) Query: 67 DFEKI-SELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPY 125 DF I +G G V K + +G A K+I + + REL+VL + N P Sbjct: 196 DFSIIDEVVGQGAFATVKKAIERTTGKTFAVKIISKRKVIGNMDGVTRELEVLQKLNHPR 255 Query: 126 IVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHK 185 IV G + + ME + GG L + G + E ++S ++ + Y+ Sbjct: 256 IVRLKGFYEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSM-G 314 Query: 186 IMHRDVKPSNILVNSRGE--IKLCDFGVSG-QLIDSMANSFVGTRSYMSPERLQGT---- 238 I HRD+KP NIL+ +K+ DFG++ Q S +F GT +Y++PE ++G Sbjct: 315 ISHRDLKPDNILIEQDDPVLVKITDFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDTSV 374 Query: 239 ---------HYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPR 289 YS D+WSMG + + G P +L G G E P Sbjct: 375 SPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIG---RGSYHEGP-- 429 Query: 290 PRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAER 349 L S E +DF++ L +P R Sbjct: 430 -----------------------------------LKDFRISEEARDFIDSLLQVDPNNR 454 Query: 350 ADLKQLMVHAFIKRSDA 366 + + + H +I S Sbjct: 455 STAAKALNHPWIVDSSN 471 >5X3F-B nrPDB Length = 393 Score = 256 bits (655), Expect = 9e-69, Method: Composition-based stats. Identities = 82/357 (22%), Positives = 151/357 (42%), Gaps = 57/357 (15%) Query: 18 SAVNGTSSAETNLEALQKKLEELE--LDEQQRKRLEAFLTQKQKVGELKDDDFEKISELG 75 S++ S NL A KKL +++ L + + L+ + T Q +L D F++I LG Sbjct: 36 SSLLDDPSQSANLLAEAKKLNDVQAFLAKAKEDFLKKWETPSQNTAQL--DQFDRIKTLG 93 Query: 76 AGNGGVVFKVSHKPSGLVMARKLIHLE--IKPAIRNQIIRELQVLHECNSPYIVGFYGAF 133 G+ G V V HK SG A K++ + +K + E ++L N P++V +F Sbjct: 94 TGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSF 153 Query: 134 YSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKP 193 + + + ME++ GG + L++ GR E + ++ YL +++RD+KP Sbjct: 154 KDNSNLYMVMEYVAGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL-DLIYRDLKP 212 Query: 194 SNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSL 253 N+L++ +G I++ DFG + ++ + GT Y++PE + Y+ D W++G+ + Sbjct: 213 ENLLIDQQGYIQVTDFGFAKRVK-GRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLI 271 Query: 254 VEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFEL 313 EMA G P A + ++ V G Sbjct: 272 YEMAAGYPPFF---ADQPIQIYEKIVSGKV------------------------------ 298 Query: 314 LDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERA-----DLKQLMVHAFIKRSD 365 + PS FS + +D + L + +R + + H + +D Sbjct: 299 ----------RFPSH-FSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTD 344 >3MIA-A nrPDB Length = 351 Score = 256 bits (655), Expect = 1e-68, Method: Composition-based stats. Identities = 82/331 (24%), Positives = 139/331 (41%), Gaps = 36/331 (10%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEI-KPAIRNQIIRELQVLHECNSPYI 126 +EK++++G G G VFK H+ +G +A K + +E K +RE+++L + Sbjct: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 Query: 127 VGFYGAFYSD--------GEISICMEHMDG---GSLDQVLKKAGRIPEQILGKVSIAVIK 175 V + G I + + + G L VL K + +V ++ Sbjct: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK---FTLSEIKRVMQMLLN 135 Query: 176 GLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLI------DSMANSFVGTRSY 229 GL Y+ ++KI+HRD+K +N+L+ G +KL DFG++ + + V T Y Sbjct: 136 GLYYIH-RNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWY 194 Query: 230 MSPERLQGTH-YSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPP 288 PE L G Y D+W G + EM R PI + ++ +L Q+ G Sbjct: 195 RPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALISQLCGSIT---- 249 Query: 289 RPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAE 348 P +D+ EL+ + +L + V D ++K L+ +PA+ Sbjct: 250 -------PEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQ 302 Query: 349 RADLKQLMVHAFIKRSDAEEVDFAGWLCSTI 379 R D + H F SD D G L + + Sbjct: 303 RIDSDDALNHDFF-WSDPMPSDLKGMLSTHL 332 >2VZ6-A nrPDB Length = 313 Score = 256 bits (655), Expect = 1e-68, Method: Composition-based stats. Identities = 63/302 (20%), Positives = 117/302 (38%), Gaps = 47/302 (15%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIH-LEIKPAIRNQIIRELQVLHECNSPYI 126 ++ ELG G VV + +G A K+I+ ++ ++ RE ++ P I Sbjct: 24 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 83 Query: 127 VGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKI 186 V + + +G + + + GG L + + E +++ + + + + Sbjct: 84 VRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQM-GV 142 Query: 187 MHRDVKPSNILVNSRGE---IKLCDFGVSGQLIDSMAN--SFVGTRSYMSPERLQGTHYS 241 +HRD+KP N+L+ S+ + +KL DFG++ ++ F GT Y+SPE L+ Y Sbjct: 143 VHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYG 202 Query: 242 VQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYG 301 D+W+ G+ L + VG P D L Sbjct: 203 KPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKA------------------------ 238 Query: 302 MDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFI 361 + P P+ + E +D +NK L NP++R + + H +I Sbjct: 239 --------------GAYDFPSPEW--DTVTPEAKDLINKMLTINPSKRITAAEALKHPWI 282 Query: 362 KR 363 Sbjct: 283 SH 284 >4BBM-A nrPDB Length = 331 Score = 256 bits (655), Expect = 1e-68, Method: Composition-based stats. Identities = 78/308 (25%), Positives = 133/308 (43%), Gaps = 18/308 (5%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARK-LIHLEIKPAIRNQIIRELQVLHECNSP 124 + +E + +G G+ G+V K +K +G ++A K + + ++ +RE+++L + Sbjct: 25 EKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHE 84 Query: 125 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKH 184 +V + E +D LD + + Q++ K +I G+ + H Sbjct: 85 NLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIGFCHS-H 143 Query: 185 KIMHRDVKPSNILVNSRGEIKLCDFGVSGQL--IDSMANSFVGTRSYMSPERLQGT-HYS 241 I+HRD+KP NILV+ G +KLCDFG + L + + V TR Y +PE L G Y Sbjct: 144 NIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYDDEVATRWYRAPELLVGDVKYG 203 Query: 242 VQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYG 301 D+W++G + EM +G P+ P D+ +L G+ P Sbjct: 204 KAVDVWAIGCLVTEMFMGE-PLFPGDSDIDQLYHIMMCLGNLI-----------PRHQEL 251 Query: 302 MDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFI 361 + P A L + EP + + S D KCL +P +R +L+ H F Sbjct: 252 FNKNPVFAGVRLPEIKEREPLERRYPKL-SEVVIDLAKKCLHIDPDKRPFCAELLHHDFF 310 Query: 362 KRSDAEEV 369 + E Sbjct: 311 QMDGFAER 318 >3MV5-A nrPDB Length = 342 Score = 256 bits (655), Expect = 1e-68, Method: Composition-based stats. Identities = 73/306 (23%), Positives = 121/306 (39%), Gaps = 53/306 (17%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRN--QIIRELQVLHECNS 123 ++FE + LG G G V V K +G A K++ E+ A + E +VL Sbjct: 10 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 69 Query: 124 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREK 183 P++ +F + + ME+ +GG L L + E ++ L YL + Sbjct: 70 PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSE 129 Query: 184 HKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS--MANSFVGTRSYMSPERLQGTHYS 241 +++RD+K N++++ G IK+ DFG+ + I +F GT Y++PE L+ Y Sbjct: 130 KNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYG 189 Query: 242 VQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYG 301 D W +G+ + EM GR P D ++L + E PRT G Sbjct: 190 RAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELI-------LMEEIRFPRTLG------- 235 Query: 302 MDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERA-----DLKQLM 356 E + ++ L K+P +R D K++M Sbjct: 236 ------------------------------PEAKSLLSGLLKKDPKQRLGGGSEDAKEIM 265 Query: 357 VHAFIK 362 H F Sbjct: 266 QHRFFA 271 >3BHH-A nrPDB Length = 295 Score = 255 bits (652), Expect = 2e-68, Method: Composition-based stats. Identities = 60/304 (19%), Positives = 120/304 (39%), Gaps = 47/304 (15%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIH-LEIKPAIRNQIIRELQVLHECNSP 124 D+++ ++G G VV + +G A K+I+ ++ ++ RE ++ Sbjct: 4 DEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHS 63 Query: 125 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKH 184 IV + + +G + + + GG L + + E +++ + + + Sbjct: 64 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQM- 122 Query: 185 KIMHRDVKPSNILVNSRGE---IKLCDFGVSGQLIDSMAN--SFVGTRSYMSPERLQGTH 239 ++HRD+KP N+L+ S+ + +KL DFG++ ++ F GT Y+SPE L+ Sbjct: 123 GVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEA 182 Query: 240 YSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSS 299 Y DIW+ G+ L + VG P D +L Sbjct: 183 YGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKA---------------------- 220 Query: 300 YGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHA 359 + P P+ + E ++ +N+ L NPA+R + + H Sbjct: 221 ----------------GAYDFPSPEW--DTVTPEAKNLINQMLTINPAKRITAHEALKHP 262 Query: 360 FIKR 363 ++ + Sbjct: 263 WVCQ 266 >5AWM-A nrPDB Length = 394 Score = 255 bits (651), Expect = 2e-68, Method: Composition-based stats. Identities = 73/316 (23%), Positives = 140/316 (44%), Gaps = 20/316 (6%) Query: 67 DFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIR-NQIIRELQVLHECNSPY 125 + + +G+G G+V + +A K + + + RE +++ N Sbjct: 45 RYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKN 104 Query: 126 IVGFYGAFYSDGEI------SICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTY 179 I+G AF + + ME MD +L QV++ + + + ++ G+ + Sbjct: 105 IIGLLNAFTPQRNLEEFQDVYLVMELMDA-NLCQVIQM--DLDHDRMSYLLYQMLCGIKH 161 Query: 180 LREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS-MANSFVGTRSYMSPERLQGT 238 L I+HRD+KPSNI+V + +K+ DFG++ + M +V TR Y +PE + G Sbjct: 162 LHSA-GIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGM 220 Query: 239 HYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLS 298 Y+ DIWS+G + EM G P D + + +E +P + + Sbjct: 221 GYTENVDIWSVGCIMGEMIRGGVLFPGTDHID---QWNKIIEQLGTPSPSFMQRLQPTVR 277 Query: 299 SYGMDSRPPMAIFELLDYIVNEPPPKLPSG---VFSLEFQDFVNKCLIKNPAERADLKQL 355 +Y +++RP + + P + + + ++ ++K L+ +P +R + + Sbjct: 278 NY-VENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEA 336 Query: 356 MVHAFIK-RSDAEEVD 370 + H +I DAEEVD Sbjct: 337 LKHEYINVWYDAEEVD 352 >3ZDU-A nrPDB Length = 325 Score = 255 bits (651), Expect = 3e-68, Method: Composition-based stats. Identities = 78/304 (25%), Positives = 137/304 (45%), Gaps = 17/304 (5%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIV 127 +E + ++G G+ G V K HK +G ++A K+ + + ++ +RE++ L + + +V Sbjct: 5 YETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQFHHENLV 64 Query: 128 GFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIM 187 F +I + E +D LD++ + + L K +++ + YL + I+ Sbjct: 65 NLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHS-NNII 123 Query: 188 HRDVKPSNILVNSRGEIKLCDFGVSGQL--IDSMANSFVGTRSYMSPE-RLQGTHYSVQS 244 HRD+KP NILV+ G KLCDFG + L + + V TR Y +PE L+ T Y Sbjct: 124 HRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYDDEVATRWYRAPELVLKDTSYGKPV 183 Query: 245 DIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDS 304 DIW++G ++EMA G P P + L G+ + + S Sbjct: 184 DIWALGCMIIEMATG-NPYLPSSSDLDLLHKIVLKVGNLSP------------HLQNIFS 230 Query: 305 RPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRS 364 + P+ +L + + + + D V+ CL +PA+R L+ H + R Sbjct: 231 KSPIFAGVVLPQVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYFTRD 290 Query: 365 DAEE 368 E Sbjct: 291 GFIE 294 >5J5T-A nrPDB Length = 370 Score = 255 bits (651), Expect = 3e-68, Method: Composition-based stats. Identities = 90/306 (29%), Positives = 145/306 (47%), Gaps = 48/306 (15%) Query: 65 DDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSP 124 +DFE I +G+G G V+K + +G + A K+I LE + +E+ ++ +C P Sbjct: 3 QEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDF-AVVQQEIIMMKDCKHP 61 Query: 125 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKH 184 IV ++G++ ++ ICME GGSL + G + E + VS ++GL YL K Sbjct: 62 NIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSKG 121 Query: 185 KIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS--MANSFVGTRSYMSPERL---QGTH 239 K MHRD+K +NIL+ G +KL DFGVS Q+ + +F+GT +M+PE + Sbjct: 122 K-MHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKAFIGTPYWMAPEVAAVERKGG 180 Query: 240 YSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSS 299 Y+ D+W++G++ +E+A + P Sbjct: 181 YNQLCDLWAVGITAIELAELQPP------------------------------------- 203 Query: 300 YGMDSRPPMAIFELLDYIVNEPPPKLPSGV-FSLEFQDFVNKCLIKNPAERADLKQLMVH 358 D P A+F + N PPKL + +S F FV L KNP +R ++L+ H Sbjct: 204 -MFDLHPMRALFLMTK--SNFQPPKLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQH 260 Query: 359 AFIKRS 364 F+ + Sbjct: 261 PFVTQH 266 >5N23-A nrPDB Length = 352 Score = 255 bits (651), Expect = 3e-68, Method: Composition-based stats. Identities = 79/348 (22%), Positives = 141/348 (40%), Gaps = 58/348 (16%) Query: 29 NLEALQKKLEELELDEQQRKRLEAFL----TQKQKVGELKDDDFEKISELGAGNGGVVFK 84 N A +K E+ + E K E FL + Q L D FE+I LG G+ G V Sbjct: 3 NAAAAKKGSEQESVKEFLAKAKEDFLKKWESPAQNTAHL--DQFERIRTLGTGSFGRVML 60 Query: 85 VSHKPSGLVMARKLIHLE--IKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISIC 142 V HK +G A K++ + +K + E ++ N P++V +F + + + Sbjct: 61 VKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRIQQAVNFPFLVKLEFSFKDNSNLYMV 120 Query: 143 MEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRG 202 +E+ GG + L++ GR E + ++ YL +++RD+KP N+L++ +G Sbjct: 121 LEYAPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL-DLIYRDLKPENLLIDQQG 179 Query: 203 EIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYP 262 IK+ DFG + ++ + GT Y++PE + Y+ D W++G+ + EMA G P Sbjct: 180 YIKVADFGFAKRVKGRTPWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPP 239 Query: 263 IPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPP 322 A + ++ V G Sbjct: 240 FF---ADQPIQIYEKIVSGKV--------------------------------------- 257 Query: 323 PKLPSGVFSLEFQDFVNKCLIKNPAERA-----DLKQLMVHAFIKRSD 365 + PS FS + +D + L + +R + + H + +D Sbjct: 258 -RFPSH-FSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTD 303 >5KZ7-A nrPDB Length = 346 Score = 254 bits (650), Expect = 3e-68, Method: Composition-based stats. Identities = 68/310 (21%), Positives = 132/310 (42%), Gaps = 48/310 (15%) Query: 62 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHL-EIKPAIRNQIIRELQVLHE 120 + ++ + +G GN V H +G +A K+I ++ + ++ RE++++ Sbjct: 29 QPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKV 88 Query: 121 CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL 180 N P IV + ++ + + ME+ GG + L GR+ E+ ++ + Y Sbjct: 89 LNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYC 148 Query: 181 REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLI-DSMANSFVGTRSYMSPERLQGTH 239 +K I+HRD+K N+L+++ IK+ DFG S + + ++F G+ Y +PE QG Sbjct: 149 HQKF-IVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKK 207 Query: 240 YS-VQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLS 298 Y + D+WS+G+ L + G P + KEL Sbjct: 208 YDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELR-------------------------- 241 Query: 299 SYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVH 358 R + + Y+ S + ++ + K LI NP++R L+Q+M Sbjct: 242 -----ERVLRGKYRIPFYM-------------STDCENLLKKFLILNPSKRGTLEQIMKD 283 Query: 359 AFIKRSDAEE 368 ++ ++ Sbjct: 284 RWMNVGHEDD 293 >3SOA-A nrPDB Length = 444 Score = 254 bits (650), Expect = 4e-68, Method: Composition-based stats. Identities = 61/304 (20%), Positives = 118/304 (38%), Gaps = 47/304 (15%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIH-LEIKPAIRNQIIRELQVLHECNSP 124 ++++ ELG G VV + +G A +I+ ++ ++ RE ++ P Sbjct: 11 EEYQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDHQKLEREARICRLLKHP 70 Query: 125 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKH 184 IV + + +G + + + GG L + + E +++ + + + Sbjct: 71 NIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQM- 129 Query: 185 KIMHRDVKPSNILVNSRGE---IKLCDFGVSGQLIDSMAN--SFVGTRSYMSPERLQGTH 239 ++HR++KP N+L+ S+ + +KL DFG++ ++ F GT Y+SPE L+ Sbjct: 130 GVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDP 189 Query: 240 YSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSS 299 Y D+W+ G+ L + VG P D L Sbjct: 190 YGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKA---------------------- 227 Query: 300 YGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHA 359 + P P+ + E +D +NK L NP++R + + H Sbjct: 228 ----------------GAYDFPSPEW--DTVTPEAKDLINKMLTINPSKRITAAEALKHP 269 Query: 360 FIKR 363 +I Sbjct: 270 WISH 273 >2F9G-A nrPDB Length = 353 Score = 254 bits (648), Expect = 6e-68, Method: Composition-based stats. Identities = 79/317 (24%), Positives = 137/317 (43%), Gaps = 33/317 (10%) Query: 67 DFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYI 126 DF+ S LG G GVV +HKP+G ++A K I KP + +RE+++L I Sbjct: 12 DFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENI 71 Query: 127 VGFY-----GAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLR 181 + + +F + E+ I E M L +V+ + + + ++ + L Sbjct: 72 ITIFNIQRPDSFENFNEVYIIQELMQT-DLHRVI-STQMLSDDHIQYFIYQTLRAVKVLH 129 Query: 182 EKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA------------NSFVGTRSY 229 + ++HRD+KPSN+L+NS ++K+CDFG++ + +S A +V TR Y Sbjct: 130 GSN-VIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWY 188 Query: 230 MSPER-LQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPP 288 +PE L YS D+WS G L E+ + R P D + L+ + ++ Sbjct: 189 RAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDL 248 Query: 289 RPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAE 348 R R + S P L P + D + + L+ +PA+ Sbjct: 249 RCIESPRAREY--IKSLPMYPAAPLEKMFPRVNPKGI----------DLLQRMLVFDPAK 296 Query: 349 RADLKQLMVHAFIKRSD 365 R K+ + H +++ Sbjct: 297 RITAKEALEHPYLQTYH 313 >5DBX-A nrPDB Length = 328 Score = 254 bits (648), Expect = 7e-68, Method: Composition-based stats. Identities = 87/347 (25%), Positives = 153/347 (44%), Gaps = 67/347 (19%) Query: 61 GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE 120 + D +E +G+G VV KP +A K I+LE +++++E+Q + + Sbjct: 6 WPICRDAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMSQ 65 Query: 121 CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLK--------KAGRIPEQILGKVSIA 172 C+ P +V +Y +F E+ + M+ + GGS+ ++K K G + E I+ + Sbjct: 66 CSHPNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKE 125 Query: 173 VIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL-------IDSMANSFVG 225 V++GL YL ++ +HRD+K NIL+ G +++ DFGVS L + + FVG Sbjct: 126 VLEGLDYLH-RNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKDFVG 184 Query: 226 TRSYMSPERLQG-THYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAA 284 T +M+PE ++ Y ++D+WS G++ +E+A G P Sbjct: 185 TPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPY--------------------- 223 Query: 285 ETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLE--------FQD 336 PPM + L + PP L +GV E F+ Sbjct: 224 ------------------HKYPPMKVLMLT---LQNDPPTLETGVEDKEMMKKYGKSFRK 262 Query: 337 FVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQ 383 ++ CL K+P++R +L+ F +++ E L T + Q Sbjct: 263 LLSLCLQKDPSKRPTAAELLKCKFFQKAKNREYLIEKLLTRTPDIAQ 309 >6FD3-A nrPDB Length = 300 Score = 254 bits (648), Expect = 7e-68, Method: Composition-based stats. Identities = 82/326 (25%), Positives = 147/326 (45%), Gaps = 51/326 (15%) Query: 43 DEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE 102 DE+ ++L + ++ VG+ K + + ++G G G V+ +G +A K ++L+ Sbjct: 4 DEEILEKLRSIVS----VGDPK-KKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQ 58 Query: 103 IKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIP 162 +P + II E+ V+ E +P IV + ++ E+ + ME++ GGSL V+ + + Sbjct: 59 QQPK-KELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETC-MD 116 Query: 163 EQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMAN- 221 E + V ++ L +L ++++HRD+K NIL+ G +KL DFG Q+ + Sbjct: 117 EGQIAAVCRECLQALDFLHS-NQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKR 175 Query: 222 -SFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVE 280 + VGT +M+PE + Y + DIWS+G+ +EM G P Sbjct: 176 STMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPY----------------- 218 Query: 281 GDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNK 340 ++ P A++ + N P S F+DF+N+ Sbjct: 219 ---------------------LNENPLRALYLI---ATNGTPELQNPERLSAVFRDFLNR 254 Query: 341 CLIKNPAERADLKQLMVHAFIKRSDA 366 CL + R K+L+ H F+K Sbjct: 255 CLEMDVDRRGSAKELLQHPFLKLDKP 280 >2JDO-A nrPDB Length = 342 Score = 253 bits (647), Expect = 8e-68, Method: Composition-based stats. Identities = 76/317 (23%), Positives = 127/317 (40%), Gaps = 54/317 (17%) Query: 62 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRN--QIIRELQVLH 119 ++ +DF+ + LG G G V V K +G A K++ E+ A + E +VL Sbjct: 6 KVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQ 65 Query: 120 ECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTY 179 P++ AF + + ME+ +GG L L + E+ ++ L Y Sbjct: 66 NTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEY 125 Query: 180 LREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS--MANSFVGTRSYMSPERLQG 237 L + +++RD+K N++++ G IK+ DFG+ + I +F GT Y++PE L+ Sbjct: 126 LHSR-DVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLED 184 Query: 238 THYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPL 297 Y D W +G+ + EM GR P D + L Sbjct: 185 NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERL-------------------------- 218 Query: 298 SSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERA-----DL 352 FEL+ P L S E + + L K+P +R D Sbjct: 219 -------------FELILMEEIRFPRTL-----SPEAKSLLAGLLKKDPKQRLGGGPSDA 260 Query: 353 KQLMVHAFIKRSDAEEV 369 K++M H F + ++V Sbjct: 261 KEVMEHRFFLSINWQDV 277 >3MN3-A nrPDB Length = 271 Score = 253 bits (645), Expect = 1e-67, Method: Composition-based stats. Identities = 70/305 (22%), Positives = 126/305 (41%), Gaps = 50/305 (16%) Query: 67 DFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEI--KPAIRNQIIRELQVLHECNSP 124 +++ + LG G+ G V H +G +A K+I+ ++ K ++ +I RE+ L P Sbjct: 5 NYQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRHP 64 Query: 125 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKH 184 +I+ Y S EI + +E+ G L + + ++ EQ + +I + Y +H Sbjct: 65 HIIKLYDVIKSKDEIIMVIEYA-GNELFDYIVQRDKMSEQEARRFFQQIISAVEYCH-RH 122 Query: 185 KIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID-SMANSFVGTRSYMSPERLQGTHY-SV 242 KI+HRD+KP N+L++ +K+ DFG+S + D + + G+ +Y +PE + G Y Sbjct: 123 KIVHRDLKPENLLLDEHLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKLYAGP 182 Query: 243 QSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGM 302 + D+WS G+ L M R P D + + ++F G Sbjct: 183 EVDVWSCGVILYVMLCRRLPF---DDESIPVLFKNISNGVYTL----------------- 222 Query: 303 DSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIK 362 S + + LI NP R + ++M + K Sbjct: 223 ------------------------PKFLSPGAAGLIKRMLIVNPLNRISIHEIMQDDWFK 258 Query: 363 RSDAE 367 E Sbjct: 259 VDLPE 263 >2YZA-A nrPDB Length = 276 Score = 253 bits (645), Expect = 1e-67, Method: Composition-based stats. Identities = 67/308 (21%), Positives = 121/308 (39%), Gaps = 49/308 (15%) Query: 61 GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIR--NQIIRELQVL 118 G +K + LG G G V H+ +G +A K+++ + ++ +I RE+Q L Sbjct: 6 GRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNL 65 Query: 119 HECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLT 178 P+I+ Y + + + ME++ GG L + K GR+ E ++ ++ + Sbjct: 66 KLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVD 125 Query: 179 YLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID-SMANSFVGTRSYMSPERLQG 237 Y +H ++HRD+KP N+L+++ K+ DFG+S + D G+ +Y +PE + G Sbjct: 126 YCH-RHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRDSCGSPNYAAPEVISG 184 Query: 238 THY-SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRP 296 Y + DIWS G+ L + G P E ++ G P Sbjct: 185 RLYAGPEVDIWSCGVILYALLCGTLPF----DDEHVPTLFKKIRGGVFYIPEYLNRSVAT 240 Query: 297 LSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLM 356 + L +P +RA +K + Sbjct: 241 ----------------------------------------LLMHMLQVDPLKRATIKDIR 260 Query: 357 VHAFIKRS 364 H + K+ Sbjct: 261 EHEWFKQD 268 >3D2K-A nrPDB Length = 272 Score = 253 bits (645), Expect = 1e-67, Method: Composition-based stats. Identities = 71/309 (22%), Positives = 132/309 (42%), Gaps = 47/309 (15%) Query: 62 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE--IKPAIRNQIIRELQVLH 119 + +DF+ LG G G V+ + S ++A K++ K + +Q+ RE+++ Sbjct: 8 QWTLEDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVEHQLRREVEIQS 67 Query: 120 ECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTY 179 P I+ YG F+ + + +E+ G++ + L+K R EQ + L+Y Sbjct: 68 HLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSRFDEQRTATYITELANALSY 127 Query: 180 LREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTH 239 K +++HRD+KP N+L+ S GE+K+ DFG S S + GT Y+ PE ++G Sbjct: 128 CHSK-RVIHRDIKPENLLLGSNGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRM 186 Query: 240 YSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSS 299 + + D+WS+G+ E VG P +E Sbjct: 187 HDEKVDLWSLGVLCYEFLVGMPPFEAHTYQETY--------------------------- 219 Query: 300 YGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHA 359 R F D++ + +D +++ L N ++R L +++ H Sbjct: 220 ----RRISRVEFTFPDFV-------------TEGARDLISRLLKHNASQRLTLAEVLEHP 262 Query: 360 FIKRSDAEE 368 +IK + ++ Sbjct: 263 WIKANSSKP 271 >1JNK-A nrPDB Length = 423 Score = 253 bits (645), Expect = 1e-67, Method: Composition-based stats. Identities = 73/315 (23%), Positives = 137/315 (43%), Gaps = 19/315 (6%) Query: 67 DFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIR-NQIIRELQVLHECNSPY 125 ++ + +G+G G+V +A K + + + REL ++ N Sbjct: 63 RYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKN 122 Query: 126 IVGFYGAFYSD------GEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTY 179 I+ F ++ + ME MD +L QV++ + + + + ++ G+ + Sbjct: 123 IISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQM--ELDHERMSYLLYQMLCGIKH 179 Query: 180 LREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS-MANSFVGTRSYMSPERLQGT 238 L I+HRD+KPSNI+V S +K+ DFG++ S M +V TR Y +PE + G Sbjct: 180 LHSA-GIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGM 238 Query: 239 HYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLS 298 Y DIWS+G + EM + P D + + +E P + + Sbjct: 239 GYKENVDIWSVGCIMGEMVRHKILFPGRDYID---QWNKVIEQLGTPCPEFMKKLQPTVR 295 Query: 299 SYGMDSRPPMAIFELLDYIVNE--PPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLM 356 +Y +++RP A + P + + + + +D ++K L+ +PA+R + + Sbjct: 296 NY-VENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDAL 354 Query: 357 VHAFIK-RSDAEEVD 370 H +I D EV+ Sbjct: 355 QHPYINVWYDPAEVE 369 >5D7A-A nrPDB Length = 308 Score = 252 bits (643), Expect = 2e-67, Method: Composition-based stats. Identities = 93/329 (28%), Positives = 152/329 (46%), Gaps = 62/329 (18%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHEC-NSPYI 126 FE + +G G G V+K H +G + A K++ ++ +I +E+ +L + + I Sbjct: 19 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVM--DVTGDEEEEIKQEINMLKKYSHHRNI 76 Query: 127 VGFYGAFYSDGE------ISICMEHMDGGSLDQVLK--KAGRIPEQILGKVSIAVIKGLT 178 +YGAF + + ME GS+ ++K K + E+ + + +++GL+ Sbjct: 77 ATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLS 136 Query: 179 YLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS--MANSFVGTRSYMSPERLQ 236 +L +HK++HRD+K N+L+ E+KL DFGVS QL + N+F+GT +M+PE + Sbjct: 137 HLH-QHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIA 195 Query: 237 -----GTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPR 291 Y +SD+WS+G++ +EMA G P+ Sbjct: 196 CDENPDATYDFKSDLWSLGITAIEMAEGAPPL---------------------------- 227 Query: 292 TPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERAD 351 D P A+F I P P+L S +S +FQ F+ CL+KN ++R Sbjct: 228 ----------CDMHPMRALF----LIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPA 273 Query: 352 LKQLMVHAFIKRSDAEEVDFAGWLCSTIG 380 +QLM H FI R E L I Sbjct: 274 TEQLMKHPFI-RDQPNERQVRIQLKDHID 301 >4UZD-A nrPDB Length = 287 Score = 252 bits (643), Expect = 2e-67, Method: Composition-based stats. Identities = 72/311 (23%), Positives = 134/311 (43%), Gaps = 47/311 (15%) Query: 62 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE--IKPAIRNQIIRELQVLH 119 + +DFE LG G G V+ K S ++A K++ K + +Q+ RE+++ Sbjct: 4 QWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQS 63 Query: 120 ECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTY 179 P I+ YG F+ + + +E+ G++ + L+K + EQ + L+Y Sbjct: 64 HLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSY 123 Query: 180 LREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTH 239 K +++HRD+KP N+L+ S GE+K+ DFG S S + GT Y+ PE ++G Sbjct: 124 CHSK-RVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRM 182 Query: 240 YSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSS 299 + + D+WS+G+ E VG+ P +E Sbjct: 183 HDEKVDLWSLGVLCYEFLVGKPPFEANTYQETY--------------------------- 215 Query: 300 YGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHA 359 R F D+ + +D +++ L NP++R L++++ H Sbjct: 216 ----KRISRVEFTFPDF-------------VTEGARDLISRLLKHNPSQRPMLREVLEHP 258 Query: 360 FIKRSDAEEVD 370 +I + ++ + Sbjct: 259 WITANSSKPSN 269 >2JAM-A nrPDB Length = 304 Score = 251 bits (642), Expect = 3e-67, Method: Composition-based stats. Identities = 77/328 (23%), Positives = 124/328 (37%), Gaps = 47/328 (14%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQ-IIRELQVLHECNSPYI 126 F + LG+G VF V + +G + A K I PA R+ + E+ VL + I Sbjct: 11 FIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKK--SPAFRDSSLENEIAVLKKIKHENI 68 Query: 127 VGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKI 186 V + S + M+ + GG L + + G E+ V V+ + YL E + I Sbjct: 69 VTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHE-NGI 127 Query: 187 MHRDVKPSNILV---NSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQ 243 +HRD+KP N+L +I + DFG+S + + ++ GT Y++PE L YS Sbjct: 128 VHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGIMSTACGTPGYVAPEVLAQKPYSKA 187 Query: 244 SDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMD 303 D WS+G+ + G P +L Sbjct: 188 VDCWSIGVITYILLCGYPPFYEETESKL-------------------------------- 215 Query: 304 SRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKR 363 FE + E + S +DF+ L K+P ER ++ + H +I Sbjct: 216 -------FEKIKEGYYEFESPFWDDI-SESAKDFICHLLEKDPNERYTCEKALSHPWIDG 267 Query: 364 SDAEEVDFAGWLCSTIGLNQPSTPTHAA 391 + A D + I N + A Sbjct: 268 NTALHRDIYPSVSLQIQKNFAKSKWRQA 295 >3TAC-A nrPDB Length = 361 Score = 251 bits (642), Expect = 3e-67, Method: Composition-based stats. Identities = 77/327 (23%), Positives = 134/327 (40%), Gaps = 61/327 (18%) Query: 58 QKVGELKDDD------FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIR--- 108 G + DDD +E +G G VV + ++ +G A K++ + + Sbjct: 12 VPRGSMADDDVLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLS 71 Query: 109 -NQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSL-DQVLKKAG---RIPE 163 + RE + H P+IV + SDG + + E MDG L +++K+A E Sbjct: 72 TEDLKREASICHMLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSE 131 Query: 164 QILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGE---IKLCDFGVSGQLIDS-- 218 + +++ L Y + + I+HRDVKP +L+ S+ +KL FGV+ QL +S Sbjct: 132 AVASHYMRQILEALRYCHD-NNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGL 190 Query: 219 MANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQ 278 +A VGT +M+PE ++ Y D+W G+ L + G P + Sbjct: 191 VAGGRVGTPHFMAPEVVKREPYGKPVDVWGCGVILFILLSGCLPFYGTKER--------- 241 Query: 279 VEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFV 338 +FE + + P+ S + S +D V Sbjct: 242 -------------------------------LFEGIIKGKYKMNPRQWSHI-SESAKDLV 269 Query: 339 NKCLIKNPAERADLKQLMVHAFIKRSD 365 + L+ +PAER + + + H ++K D Sbjct: 270 RRMLMLDPAERITVYEALNHPWLKERD 296 >4JDH-A nrPDB Length = 346 Score = 251 bits (642), Expect = 3e-67, Method: Composition-based stats. Identities = 85/353 (24%), Positives = 157/353 (44%), Gaps = 56/353 (15%) Query: 22 GTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELKD-----DDFEKISELGA 76 G + + N + E QR E F Q V + D D+F ++G Sbjct: 28 GARARQENGMPEKPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFI---KIGE 84 Query: 77 GNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSD 136 G+ G+V + + SG ++A K + L K R + E+ ++ + +V Y ++ Sbjct: 85 GSTGIVCIATVRSSGKLVAVKKMDLR-KQQRRELLFNEVVIMRDYQHENVVEMYNSYLVG 143 Query: 137 GEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNI 196 E+ + ME ++GG+L ++ R+ E+ + V +AV++ L+ L + ++HRD+K +I Sbjct: 144 DELWVVMEFLEGGALTDIVTHT-RMNEEQIAAVCLAVLQALSVLHAQ-GVIHRDIKSDSI 201 Query: 197 LVNSRGEIKLCDFGVSGQLIDSMA--NSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLV 254 L+ G +KL DFG Q+ + S VGT +M+PE + Y + DIWS+G+ ++ Sbjct: 202 LLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVI 261 Query: 255 EMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELL 314 EM G P + PP+ + Sbjct: 262 EMVDGEPPYF---------------------------------------NEPPLKA---M 279 Query: 315 DYIVNEPPPKLPS-GVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDA 366 I + PP+L + S + F+++ L+++PA+RA +L+ H F+ ++ Sbjct: 280 KMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGP 332 >2W4O-A nrPDB Length = 349 Score = 251 bits (641), Expect = 3e-67, Method: Composition-based stats. Identities = 71/301 (23%), Positives = 123/301 (40%), Gaps = 47/301 (15%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPY 125 D FE SELG G +V++ K + A K++ + I + E+ VL + P Sbjct: 53 DFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKI---VRTEIGVLLRLSHPN 109 Query: 126 IVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHK 185 I+ F + EIS+ +E + GG L + + G E+ +++ + YL E + Sbjct: 110 IIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHE-NG 168 Query: 186 IMHRDVKPSNILVNS---RGEIKLCDFGVSGQLIDS-MANSFVGTRSYMSPERLQGTHYS 241 I+HRD+KP N+L + +K+ DFG+S + + + GT Y +PE L+G Y Sbjct: 169 IVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYG 228 Query: 242 VQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYG 301 + D+WS+G+ + G P D + + MF + + P Sbjct: 229 PEVDMWSVGIITYILLCGFEPF--YDERGDQFMFRRILNCEYYFISP------------- 273 Query: 302 MDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFI 361 SL +D V K ++ +P +R Q + H ++ Sbjct: 274 ------------------------WWDEVSLNAKDLVRKLIVLDPKKRLTTFQALQHPWV 309 Query: 362 K 362 Sbjct: 310 T 310 >2Q0N-A nrPDB Length = 301 Score = 251 bits (641), Expect = 4e-67, Method: Composition-based stats. Identities = 83/334 (24%), Positives = 152/334 (45%), Gaps = 56/334 (16%) Query: 41 ELDEQQRKRLEAFLTQKQKVGELKD-----DDFEKISELGAGNGGVVFKVSHKPSGLVMA 95 E QR E F Q V + D D+F ++G G+ G+V + + SG ++A Sbjct: 2 PQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFI---KIGEGSTGIVCIATVRSSGKLVA 58 Query: 96 RKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVL 155 K + L K R + E+ ++ + +V Y ++ E+ + ME ++GG+L ++ Sbjct: 59 VKKMDLR-KQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIV 117 Query: 156 KKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL 215 R+ E+ + V +AV++ L+ L + ++HRD+K +IL+ G +KL DFG Q+ Sbjct: 118 THT-RMNEEQIAAVCLAVLQALSVLHAQ-GVIHRDIKSDSILLTHDGRVKLSDFGFCAQV 175 Query: 216 IDSMA--NSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELEL 273 + S VGT +M+PE + Y + DIWS+G+ ++EM G P Sbjct: 176 SKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYF--------- 226 Query: 274 MFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPS-GVFSL 332 + PP+ + I + PP+L + S Sbjct: 227 ------------------------------NEPPLKA---MKMIRDNLPPRLKNLHKVSP 253 Query: 333 EFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDA 366 + F+++ L+++PA+RA +L+ H F+ ++ Sbjct: 254 SLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGP 287 >4KS7-A nrPDB Length = 292 Score = 251 bits (641), Expect = 4e-67, Method: Composition-based stats. Identities = 76/295 (25%), Positives = 137/295 (46%), Gaps = 48/295 (16%) Query: 73 ELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGA 132 ++G G+ G+V K SG +A K++ L K R + E+ ++ + +V Y + Sbjct: 30 KIGEGSTGIVCLAREKHSGRQVAVKMMDLR-KQQRRELLFNEVVIMRDYQHFNVVEMYKS 88 Query: 133 FYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVK 192 + E+ + ME + GG+L ++ + R+ E+ + V AV++ L YL + ++HRD+K Sbjct: 89 YLVGEELWVLMEFLQGGALTDIVSQV-RLNEEQIATVCEAVLQALAYLHAQ-GVIHRDIK 146 Query: 193 PSNILVNSRGEIKLCDFGVSGQLIDS--MANSFVGTRSYMSPERLQGTHYSVQSDIWSMG 250 +IL+ G +KL DFG Q+ S VGT +M+PE + + Y+ + DIWS+G Sbjct: 147 SDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLG 206 Query: 251 LSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAI 310 + ++EM G P Sbjct: 207 IMVIEMVDGEPPYFSDS------------------------------------------P 224 Query: 311 FELLDYIVNEPPPKLP-SGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRS 364 + + + + PPPKL S S +DF+ + L+++P ERA ++L+ H F+ ++ Sbjct: 225 VQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQT 279 >4XBR-A nrPDB Length = 366 Score = 251 bits (640), Expect = 5e-67, Method: Composition-based stats. Identities = 83/334 (24%), Positives = 152/334 (45%), Gaps = 56/334 (16%) Query: 41 ELDEQQRKRLEAFLTQKQKVGELKD-----DDFEKISELGAGNGGVVFKVSHKPSGLVMA 95 E QR E F Q V + D D+F ++G G+ G+V + + SG ++A Sbjct: 67 PQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFI---KIGEGSTGIVCIATVRSSGKLVA 123 Query: 96 RKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVL 155 K + L K R + E+ ++ + +V Y ++ E+ + ME ++GG+L ++ Sbjct: 124 VKKMDLR-KQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIV 182 Query: 156 KKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL 215 R+ E+ + V +AV++ L+ L + ++HRD+K +IL+ G +KL DFG Q+ Sbjct: 183 THT-RMNEEQIAAVCLAVLQALSVLHAQ-GVIHRDIKSDSILLTHDGRVKLSDFGFCAQV 240 Query: 216 IDSMA--NSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELEL 273 + S VGT +M+PE + Y + DIWS+G+ ++EM G P Sbjct: 241 SKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYF--------- 291 Query: 274 MFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPS-GVFSL 332 + PP+ + I + PP+L + S Sbjct: 292 ------------------------------NEPPLKA---MKMIRDNLPPRLKNLHKVSP 318 Query: 333 EFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDA 366 + F+++ L+++PA+RA +L+ H F+ ++ Sbjct: 319 SLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGP 352 >4FIE-A nrPDB Length = 423 Score = 251 bits (640), Expect = 5e-67, Method: Composition-based stats. Identities = 83/334 (24%), Positives = 152/334 (45%), Gaps = 56/334 (16%) Query: 41 ELDEQQRKRLEAFLTQKQKVGELKD-----DDFEKISELGAGNGGVVFKVSHKPSGLVMA 95 E QR E F Q V + D D+F ++G G+ G+V + + SG ++A Sbjct: 124 PQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFI---KIGEGSTGIVCIATVRSSGKLVA 180 Query: 96 RKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVL 155 K + L K R + E+ ++ + +V Y ++ E+ + ME ++GG+L ++ Sbjct: 181 VKKMDLR-KQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIV 239 Query: 156 KKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL 215 R+ E+ + V +AV++ L+ L + ++HRD+K +IL+ G +KL DFG Q+ Sbjct: 240 THT-RMNEEQIAAVCLAVLQALSVLHAQ-GVIHRDIKSDSILLTHDGRVKLSDFGFCAQV 297 Query: 216 IDSMA--NSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELEL 273 + S VGT +M+PE + Y + DIWS+G+ ++EM G P Sbjct: 298 SKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYF--------- 348 Query: 274 MFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPS-GVFSL 332 + PP+ + I + PP+L + S Sbjct: 349 ------------------------------NEPPLKA---MKMIRDNLPPRLKNLHKVSP 375 Query: 333 EFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDA 366 + F+++ L+++PA+RA +L+ H F+ ++ Sbjct: 376 SLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGP 409 >4QNY-A nrPDB Length = 354 Score = 251 bits (640), Expect = 5e-67, Method: Composition-based stats. Identities = 80/333 (24%), Positives = 136/333 (40%), Gaps = 26/333 (7%) Query: 65 DDDFEKISELGAGNGGVVFKVSH-KPSGLVMARKLIHLEIKPAIR--NQIIRELQVLHEC 121 DD + +GAG+ GVV + K ++A K ++ EI + +I+RE+++L Sbjct: 19 DDRYLLERIIGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFEEVILAKRILREIKLLAHF 78 Query: 122 NSPYIVGFYGAFYSDG-----EISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKG 176 N I+G + I M+ M+ L QVL+ + E + ++ Sbjct: 79 NDDNIIGLRNILTPEDPENFDHFYIVMDIMET-DLKQVLRSGQELTEAHIQFFIYQALRA 137 Query: 177 LTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID--SMANSFVGTRSYMSPE- 233 L + ++HRD+ P+NILVN+ ++K+CDFG++ + D +V R Y +PE Sbjct: 138 LHIIHSA-GVIHRDITPANILVNTNCDLKICDFGLAKEENDQGEYMTDYVTMRWYRAPEL 196 Query: 234 RLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTP 293 ++ YS Q D+W +G L E+ G P+ + +L V G +E Sbjct: 197 VMEDKDYSAQIDVWGIGCILGELL-GSRPLFQGKDRVNQLDKIVDVIGTPSEEDINSVGS 255 Query: 294 GRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLK 353 S P A + S E D + L+ NP R + Sbjct: 256 SAAQKYLKKKSHRPQADWRQRYPTA------------SPEALDLLRHMLVFNPKRRITVL 303 Query: 354 QLMVHAFIKRSDAEEVDFAGWLCSTIGLNQPST 386 Q M H F+++ + D + N+ T Sbjct: 304 QAMRHPFLEQLHDDADDNLSYALFRFDENEQKT 336 >3E7O-A nrPDB Length = 360 Score = 250 bits (639), Expect = 7e-67, Method: Composition-based stats. Identities = 73/315 (23%), Positives = 137/315 (43%), Gaps = 19/315 (6%) Query: 67 DFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIR-NQIIRELQVLHECNSPY 125 ++++ +G+G G+V G+ +A K + + + REL +L N Sbjct: 23 RYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKN 82 Query: 126 IVGFYGAFYSD------GEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTY 179 I+ F ++ + ME MD +L QV+ + + + + ++ G+ + Sbjct: 83 IISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIHM--ELDHERMSYLLYQMLCGIKH 139 Query: 180 LREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS-MANSFVGTRSYMSPERLQGT 238 L I+HRD+KPSNI+V S +K+ DFG++ + M +V TR Y +PE + G Sbjct: 140 LHSA-GIIHRDLKPSNIVVKSDCTLKILDFGLARTASTNFMMTPYVVTRYYRAPEVILGM 198 Query: 239 HYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLS 298 Y DIWS+G + E+ G D + + +E + + Sbjct: 199 GYKENVDIWSVGCIMGELVKGSVIFQGTDHID---QWNKVIEQLGTPSAEFMAALQPTVR 255 Query: 299 SYGMDSRP--PMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLM 356 +Y +++RP P FE L P + + + +D ++K L+ +P +R + + + Sbjct: 256 NY-VENRPAYPGIAFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEAL 314 Query: 357 VHAFIK-RSDAEEVD 370 H +I D E + Sbjct: 315 RHPYITVWYDPAEAE 329 >5D9K-A nrPDB Length = 330 Score = 250 bits (639), Expect = 7e-67, Method: Composition-based stats. Identities = 90/329 (27%), Positives = 133/329 (40%), Gaps = 60/329 (18%) Query: 51 EAFLTQKQKVGELKDD--DFEKISELGAGNGGVVFKVSHKPSG----LVMARKLIHLE-I 103 E +T K G K D FE + LG G+ G VF V K SG + A K++ + Sbjct: 13 EIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVK-KISGSDARQLYAMKVLKKATL 71 Query: 104 KPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPE 163 K R + E +L E N P+IV + AF ++G++ + ++ + GG L L K E Sbjct: 72 KVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTE 131 Query: 164 QILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSM--AN 221 + + + L +L I++RD+KP NIL++ G IKL DFG+S + ID A Sbjct: 132 EDVKFYLAELALALDHLHSL-GIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAY 190 Query: 222 SFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEG 281 SF GT YM+PE + ++ +D WS G+ + EM G P D KE M G Sbjct: 191 SFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLG 250 Query: 282 DAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKC 341 S E Q + Sbjct: 251 MP--------------------------------------------QFLSPEAQSLLRML 266 Query: 342 LIKNPAERADL-----KQLMVHAFIKRSD 365 +NPA R +++ H+F D Sbjct: 267 FKRNPANRLGAGPDGVEEIKRHSFFSTID 295 >4EWQ-A nrPDB Length = 383 Score = 250 bits (639), Expect = 7e-67, Method: Composition-based stats. Identities = 75/343 (21%), Positives = 139/343 (40%), Gaps = 28/343 (8%) Query: 36 KLEELELDEQQRKRLEAFLTQK--QKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLV 93 E L + F Q+ + + E+ + ++ +S +G+G G V +GL Sbjct: 14 GTENLYFQSNASQERPTFYRQELNKTIWEVP-ERYQNLSPVGSGAYGSVCAAFDTKTGLR 72 Query: 94 MARKLIHLEIKPAIR-NQIIRELQVLHECNSPYIVGFYGAF------YSDGEISICMEHM 146 +A K + + I + REL++L ++G F ++ + M Sbjct: 73 VAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM 132 Query: 147 DGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKL 206 G L+ ++K ++ + + + +++GL Y+ I+HRD+KPSN+ VN E+K+ Sbjct: 133 -GADLNNIVK-CQKLTDDHVQFLIYQILRGLKYIHSA-DIIHRDLKPSNLAVNEDCELKI 189 Query: 207 CDFGVSGQLIDSMANSFVGTRSYMSPE-RLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPP 265 DFG++ D +V TR Y +PE L HY+ DIWS+G + E+ GR P Sbjct: 190 LDFGLARH-TDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPG 248 Query: 266 PDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKL 325 D +L ++ G + + + S M + + P Sbjct: 249 TDHI-DQLKLILRLVGTPGA--ELLKKISSESARNYIQSLTQMPKMNFANVFIGANPL-- 303 Query: 326 PSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEE 368 D + K L+ + +R Q + HA+ + + Sbjct: 304 --------AVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPD 338 >4PDS-A nrPDB Length = 347 Score = 250 bits (638), Expect = 8e-67, Method: Composition-based stats. Identities = 76/315 (24%), Positives = 120/315 (38%), Gaps = 58/315 (18%) Query: 67 DFEKI-SELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPY 125 DF I +G G V K + +G + K+I + + REL+VL + N P Sbjct: 31 DFSIIDEVVGQGAFATVKKAIERTTGKTFSVKIISKRKVIGNMDGVTRELEVLQKLNHPR 90 Query: 126 IVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHK 185 IV G + + ME + GG L + G + E ++S ++ + Y+ Sbjct: 91 IVRLKGFYEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSM-G 149 Query: 186 IMHRDVKPSNILVNSRGE--IKLCDFGVSG-QLIDSMANSFVGTRSYMSPERLQGT---- 238 I HRD+KP NIL+ +K+ FG++ Q S +F GT +Y++PE ++G Sbjct: 150 ISHRDLKPDNILIEQDDPVLVKITAFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDTSV 209 Query: 239 ---------HYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPR 289 YS D+WSMG + + G P +L G G E P Sbjct: 210 SPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIG---RGSYHEGP-- 264 Query: 290 PRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAER 349 L S E +DF++ L +P R Sbjct: 265 -----------------------------------LKDFRISEEARDFIDSLLQVDPNNR 289 Query: 350 ADLKQLMVHAFIKRS 364 + + + H +IK S Sbjct: 290 STAAKALNHPWIKMS 304 >1PHK-A nrPDB Length = 298 Score = 250 bits (638), Expect = 8e-67, Method: Composition-based stats. Identities = 73/320 (22%), Positives = 130/320 (40%), Gaps = 57/320 (17%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHL--------EIKPAIRNQIIRELQV 117 +++E LG G VV + HKP+ A K+I + E +R ++E+ + Sbjct: 17 ENYEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQELREATLKEVDI 76 Query: 118 LHECN-SPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKG 176 L + + P I+ + ++ + + M G L L + + E+ K+ A+++ Sbjct: 77 LRKVSGHPNIIQLKDTYETNTFFFLVFDLMKKGELFDYLTEKVTLSEKETRKIMRALLEV 136 Query: 177 LTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL-IDSMANSFVGTRSYMSPERL 235 + L K I+HRD+KP NIL++ IKL DFG S QL GT SY++PE + Sbjct: 137 ICALH-KLNIVHRDLKPENILLDDDMNIKLTDFGFSCQLDPGEKLREVCGTPSYLAPEII 195 Query: 236 QGT------HYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPR 289 + + Y + D+WS G+ + + G P ++ LM + G+ P Sbjct: 196 ECSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPFW---HRKQMLMLRMIMSGNYQFGSPE 252 Query: 290 PRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAER 349 +S +D V++ L+ P +R Sbjct: 253 WDD-------------------------------------YSDTVKDLVSRFLVVQPQKR 275 Query: 350 ADLKQLMVHAFIKRSDAEEV 369 ++ + H F ++ EEV Sbjct: 276 YTAEEALAHPFFQQYVVEEV 295 >2Z7Q-A nrPDB Length = 321 Score = 250 bits (638), Expect = 9e-67, Method: Composition-based stats. Identities = 81/263 (30%), Positives = 123/263 (46%), Gaps = 9/263 (3%) Query: 51 EAFLTQKQKVGELKDD--DFEKISELGAGNGGVVFKVSHK---PSGLVMARKLIHLE-IK 104 E +T K G K D FE + LG G+ G VF V SG + A K++ +K Sbjct: 11 EISITHHVKAGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLK 70 Query: 105 PAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQ 164 R + E +L + N P++V + AF ++G++ + ++ + GG L L K E+ Sbjct: 71 VRDRVRTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEE 130 Query: 165 ILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSM--ANS 222 + + GL +L I++RD+KP NIL++ G IKL DFG+S + ID A S Sbjct: 131 DVKFYLAELALGLDHLHSL-GIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYS 189 Query: 223 FVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGD 282 F GT YM+PE + +S +D WS G+ + EM G P D KE + G Sbjct: 190 FCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGM 249 Query: 283 AAETPPRPRTPGRPLSSYGMDSR 305 ++ R L +R Sbjct: 250 PQFLSTEAQSLLRALFKRNPANR 272 >5B2L-A nrPDB Length = 324 Score = 250 bits (638), Expect = 9e-67, Method: Composition-based stats. Identities = 122/353 (34%), Positives = 193/353 (54%), Gaps = 54/353 (15%) Query: 50 LEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRN 109 + +LT + + + +D E + E+G+G G V+K+ + +G V+A K + Sbjct: 1 MTGYLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENK 60 Query: 110 QIIRELQV-LHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKA-GRIPEQILG 167 +I+ +L V L + PYIV +G F ++ ++ I ME M G S +++ K+ G IPE+ILG Sbjct: 61 RILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELM-GTSAEKLKKRMQGPIPERILG 119 Query: 168 KVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSF-VGT 226 K+++A++K L YL+EKH ++HRDVKPSNIL++ RG+IKLCDFG+SG+L+DS A + G Sbjct: 120 KMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGC 179 Query: 227 RSYMSPERLQ-----GTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEG 281 +YM+PER+ Y +++D+WS+G+SLVE+A G++P Sbjct: 180 AAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTD------------ 227 Query: 282 DAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGV-FSLEFQDFVNK 340 FE+L ++ E PP LP + FS +FQ FV Sbjct: 228 -----------------------------FEVLTKVLQEEPPLLPGHMGFSGDFQSFVKD 258 Query: 341 CLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV 393 CL K+ +R +L+ H+FIKR + EVD A W + + +P +GV Sbjct: 259 CLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDV--MAKTESP-RTSGV 308 >5JZN-A nrPDB Length = 280 Score = 250 bits (638), Expect = 9e-67, Method: Composition-based stats. Identities = 58/302 (19%), Positives = 111/302 (36%), Gaps = 44/302 (14%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPY 125 + ++ +G GN VV + + + A K+I + I E+ +L P Sbjct: 19 ERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHMIQNEVSILRRVKHPN 78 Query: 126 IVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHK 185 IV E+ + ME + GG L + + E+ + + + YL + Sbjct: 79 IVLLIEEMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLYNLASAIKYLHSLN- 137 Query: 186 IMHRDVKPSNILV----NSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYS 241 I+HRD+KP N+LV + +KL DFG++ ++D + GT +Y++PE + T Y Sbjct: 138 IVHRDIKPENLLVYEHQDGSKSLKLGDFGLAT-IVDGPLYTVCGTPTYVAPEIIAETGYG 196 Query: 242 VQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYG 301 ++ DIW+ G+ + G P + L + +P Sbjct: 197 LKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYW------------ 244 Query: 302 MDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFI 361 S ++ + L+ + +R Q++ H ++ Sbjct: 245 --------------------------DNVSDSAKELITMMLLVDVDQRFSAVQVLEHPWV 278 Query: 362 KR 363 Sbjct: 279 ND 280 >2XS0-A nrPDB Length = 386 Score = 249 bits (637), Expect = 1e-66, Method: Composition-based stats. Identities = 77/315 (24%), Positives = 139/315 (44%), Gaps = 19/315 (6%) Query: 67 DFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIR-NQIIRELQVLHECNSPY 125 ++ + +G+G G+V +A K + + + REL ++ N Sbjct: 27 RYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKN 86 Query: 126 IVGFYGAFYSD------GEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTY 179 I+G F ++ I ME MD +L QV++ + + + + ++ G+ + Sbjct: 87 IIGLLNVFTPQKSLEEFQDVYIVMELMDA-NLCQVIQM--ELDHERMSYLLYQMLCGIKH 143 Query: 180 LREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMAN-SFVGTRSYMSPERLQGT 238 L I+HRD+KPSNI+V S +K+ DFG++ S FV TR Y +PE + G Sbjct: 144 LHSA-GIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMVPFVVTRYYRAPEVILGM 202 Query: 239 HYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLS 298 Y DIWS+G + EM G P D + + +E P + + Sbjct: 203 GYKENVDIWSVGCIMGEMIKGGVLFPGTDHID---QWNKVIEQLGTPCPEFMKKLQPTVR 259 Query: 299 SYGMDSRPPMA--IFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLM 356 +Y +++RP A FE L V P + + + + +D ++K L+ + ++R + + + Sbjct: 260 TY-VENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEAL 318 Query: 357 VHAFIK-RSDAEEVD 370 H +I D E + Sbjct: 319 QHPYINVWYDPSEAE 333 >1FOT-A nrPDB Length = 318 Score = 249 bits (635), Expect = 2e-66, Method: Composition-based stats. Identities = 71/310 (22%), Positives = 130/310 (41%), Gaps = 53/310 (17%) Query: 67 DFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEI--KPAIRNQIIRELQVLHECNSP 124 DF+ + LG G+ G V + + +G A K++ EI + E +L P Sbjct: 7 DFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTHP 66 Query: 125 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKH 184 +I+ +G F +I + M++++GG L +L+K+ R P + + V L YL K Sbjct: 67 FIIRMWGTFQDAQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYLHSK- 125 Query: 185 KIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQS 244 I++RD+KP NIL++ G IK+ DFG + + D + + GT Y++PE + Y+ Sbjct: 126 DIIYRDLKPENILLDKNGHIKITDFGFAKYVPD-VTYTLCGTPDYIAPEVVSTKPYNKSI 184 Query: 245 DIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDS 304 D WS G+ + EM G P + Sbjct: 185 DWWSFGILIYEMLAGYTPFYDSNT------------------------------------ 208 Query: 305 RPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERA-----DLKQLMVHA 359 M +E + PP F+ + +D +++ + ++ ++R + + H Sbjct: 209 ---MKTYEKILNAELRFPP-----FFNEDVKDLLSRLITRDLSQRLGNLQNGTEDVKNHP 260 Query: 360 FIKRSDAEEV 369 + K E++ Sbjct: 261 WFKEVVWEKL 270 >3UC3-A nrPDB Length = 361 Score = 249 bits (635), Expect = 2e-66, Method: Composition-based stats. Identities = 76/329 (23%), Positives = 130/329 (39%), Gaps = 47/329 (14%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPY 125 D ++ + ++G+GN GV + K + ++A K I E AI + RE+ P Sbjct: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYI--ERGAAIDENVQREIINHRSLRHPN 77 Query: 126 IVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHK 185 IV F + ++I ME+ GG L + + AGR E ++ G++Y + Sbjct: 78 IVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSM-Q 136 Query: 186 IMHRDVKPSNILVNSR--GEIKLCDFGVSG-QLIDSMANSFVGTRSYMSPERLQGTHYSV 242 I HRD+K N L++ +K+CDFG S ++ S S VGT +Y++PE L Y Sbjct: 137 ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDG 196 Query: 243 Q-SDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYG 301 + +D+WS G++L M VG YP P+ ++ P R Sbjct: 197 KIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIR---------- 246 Query: 302 MDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFI 361 S E +++ + +PA R + ++ H++ Sbjct: 247 ----------------------------ISPECCHLISRIFVADPATRISIPEIKTHSWF 278 Query: 362 KRSDAEEVDFAGWLCSTIGLNQPSTPTHA 390 D + +P P + Sbjct: 279 --LKNLPADLMNESNTGSQFQEPEQPMQS 305 >2F57-A nrPDB Length = 317 Score = 248 bits (634), Expect = 3e-66, Method: Composition-based stats. Identities = 81/332 (24%), Positives = 146/332 (43%), Gaps = 50/332 (15%) Query: 36 KLEELELDEQQRKRLEAFLTQKQKVGEL--KDDDFEKISELGAGNGGVVFKVSHKPSGLV 93 E L R E F Q V + ++G G+ G+V + K +G Sbjct: 13 GRENLYFQSMSRVSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQ 72 Query: 94 MARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQ 153 +A K + L K R + E+ ++ + + +V Y ++ E+ + ME ++GG+L Sbjct: 73 VAVKKMDLR-KQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTD 131 Query: 154 VLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSG 213 ++ R+ E+ + V ++V++ L+YL + ++HRD+K +IL+ S G IKL DFG Sbjct: 132 IVTHT-RMNEEQIATVCLSVLRALSYLHNQ-GVIHRDIKSDSILLTSDGRIKLSDFGFCA 189 Query: 214 QLIDS--MANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKEL 271 Q+ S VGT +M+PE + Y + DIWS+G+ ++EM G P Sbjct: 190 QVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYF------- 242 Query: 272 ELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPS-GVF 330 + PP+ + I + PP++ Sbjct: 243 --------------------------------NEPPLQA---MRRIRDSLPPRVKDLHKV 267 Query: 331 SLEFQDFVNKCLIKNPAERADLKQLMVHAFIK 362 S + F++ L++ P++RA ++L+ H F+K Sbjct: 268 SSVLRGFLDLMLVREPSQRATAQELLGHPFLK 299 >4YZB-A nrPDB Length = 491 Score = 248 bits (633), Expect = 3e-66, Method: Composition-based stats. Identities = 74/326 (22%), Positives = 131/326 (40%), Gaps = 50/326 (15%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE--IKPAIRNQIIRELQVLHECNS 123 D ++ LG G+ G V K +G A K+I + + +++E+++L + + Sbjct: 30 DRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTDKELLLKEVELLKKLDH 89 Query: 124 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREK 183 P I+ Y F G + E GG L + R E ++ V+ G+TY+ K Sbjct: 90 PNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMH-K 148 Query: 184 HKIMHRDVKPSNILVN---SRGEIKLCDFGVSGQLIDS-MANSFVGTRSYMSPERLQGTH 239 +KI+HRD+KP N+L+ I++ DFG+S + +GT Y++PE L GT Sbjct: 149 NKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAPEVLHGT- 207 Query: 240 YSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSS 299 Y + D+WS G+ L + G P A E +++ + + P + Sbjct: 208 YDEKCDVWSTGVILYILLSGCPPFNG--ANEFDILKKVEKGKFTFDLPQWKK-------- 257 Query: 300 YGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHA 359 S +D + K L P R + + H Sbjct: 258 ------------------------------VSEPAKDLIRKMLAYVPTMRISARDALEHE 287 Query: 360 FIKRSDA--EEVDFAGWLCSTIGLNQ 383 ++K +DA + +D + + + Q Sbjct: 288 WLKTTDAATDSIDVPSLESTILNIRQ 313 >3FI2-A nrPDB Length = 353 Score = 248 bits (633), Expect = 3e-66, Method: Composition-based stats. Identities = 70/306 (22%), Positives = 133/306 (43%), Gaps = 18/306 (5%) Query: 67 DFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIR-NQIIRELQVLHECNSPY 125 ++ + +G+G G+V +A K + + + REL ++ N Sbjct: 25 RYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKN 84 Query: 126 IVGFYGAFYSD------GEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTY 179 I+ F ++ + ME MD +L QV++ + + + + ++ G+ + Sbjct: 85 IISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQM--ELDHERMSYLLYQMLCGIKH 141 Query: 180 LREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS-MANSFVGTRSYMSPERLQGT 238 L I+HRD+KPSNI+V S +K+ DFG++ S M +V TR Y +PE + G Sbjct: 142 LHSA-GIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGM 200 Query: 239 HYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLS 298 Y DIWS+G + EM + P D + + +E P + + Sbjct: 201 GYKENVDIWSVGCIMGEMVRHKILFPGRDYID---QWNKVIEQLGTPCPEFMKKLQPTVR 257 Query: 299 SYGMDSRPPMAIFELLDYIVNE--PPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLM 356 +Y +++RP A + P + + + + +D ++K L+ +PA+R + + Sbjct: 258 NY-VENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDAL 316 Query: 357 VHAFIK 362 H +I Sbjct: 317 QHPYIN 322 >3Q5I-A nrPDB Length = 504 Score = 248 bits (633), Expect = 3e-66, Method: Composition-based stats. Identities = 66/324 (20%), Positives = 125/324 (38%), Gaps = 59/324 (18%) Query: 57 KQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHL------------EIK 104 ++K G++ + F+ + +LG+G G V K A K+I + Sbjct: 28 RKKEGKIGESYFK-VRKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYSDDNKNI 86 Query: 105 PAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQ 164 +I E+ +L + P I+ + F + E +GG L + + + E Sbjct: 87 EKFHEEIYNEISLLKSLDHPNIIKLFDVFEDKKYFYLVTEFYEGGELFEQIINRHKFDEC 146 Query: 165 ILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRG---EIKLCDFGVSGQLI-DSMA 220 + ++ G+ YL KH I+HRD+KP NIL+ ++ IK+ DFG+S D Sbjct: 147 DAANIMKQILSGICYLH-KHNIVHRDIKPENILLENKNSLLNIKIVDFGLSSFFSKDYKL 205 Query: 221 NSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVE 280 +GT Y++PE L+ Y+ + D+WS G+ + + G P + +++ Sbjct: 206 RDRLGTAYYIAPEVLK-KKYNEKCDVWSCGVIMYILLCGYPPFGGQNDQDI--------- 255 Query: 281 GDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNK 340 + E Y + K S E ++ + Sbjct: 256 ---------------------------IKKVEKGKYYFDFNDWK----NISDEAKELIKL 284 Query: 341 CLIKNPAERADLKQLMVHAFIKRS 364 L + +R ++ + +IK+ Sbjct: 285 MLTYDYNKRCTAEEALNSRWIKKY 308 >3OHT-A nrPDB Length = 389 Score = 248 bits (633), Expect = 4e-66, Method: Composition-based stats. Identities = 75/317 (23%), Positives = 136/317 (42%), Gaps = 26/317 (8%) Query: 60 VGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIR-NQIIRELQVL 118 + E+ + ++ +S +G+G G V SGL +A K + + I + REL++L Sbjct: 46 IWEVP-ERYQTLSPVGSGAYGSVCSSYDVKSGLKIAVKKLSRPFQSIIHAKRTYRELRLL 104 Query: 119 HECNSPYIVGFYGAF------YSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIA 172 ++G F ++ + M G L+ ++K ++ + + + Sbjct: 105 KHMKHENVIGLLDVFTPATSLEEFNDVYLVTHLM-GADLNNIVK-CQKLTDDHVQFLIYQ 162 Query: 173 VIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSP 232 +++GL Y+ I+HRD+KPSN+ VN E+K+ DFG++ D +V TR Y +P Sbjct: 163 ILRGLKYIHSA-DIIHRDLKPSNLAVNEDCELKILDFGLARH-TDDEMTGYVATRWYRAP 220 Query: 233 E-RLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPR 291 E L HY++ DIWS+G + E+ GR P D +L ++ G R Sbjct: 221 EIMLNWMHYNMTVDIWSVGCIMAELLTGRTLFPGTDHIN-QLQQIMRLTGTP-PASVISR 278 Query: 292 TPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERAD 351 P +Y ++S P M D + P D + K L+ + +R Sbjct: 279 MPSHEARNY-INSLPQMPKRNFADVFIGANPL----------AVDLLEKMLVLDTDKRIT 327 Query: 352 LKQLMVHAFIKRSDAEE 368 + + H + + + Sbjct: 328 ASEALAHPYFSQYHDPD 344 >3GUB-A nrPDB Length = 295 Score = 248 bits (632), Expect = 4e-66, Method: Composition-based stats. Identities = 72/320 (22%), Positives = 133/320 (41%), Gaps = 51/320 (15%) Query: 65 DDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIR-----NQIIRELQVLH 119 DD ++ ELG+G VV K K +GL A K I + R I RE+ +L Sbjct: 10 DDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILK 69 Query: 120 ECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTY 179 E P ++ + + + ++ + E + GG L L + + E+ + ++ G+ Y Sbjct: 70 EIQHPNVITLHEVYENKTDVILIGELVAGGELFDFLAEKESLTEEEATEFLKQILNGVYY 129 Query: 180 LREKHKIMHRDVKPSNILVNSRG----EIKLCDFGVSGQLI-DSMANSFVGTRSYMSPER 234 L +I H D+KP NI++ R IK+ DFG++ ++ + + GT +++PE Sbjct: 130 LHSL-QIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAPEI 188 Query: 235 LQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPG 294 + +++D+WS+G+ + G P D K+ L V Sbjct: 189 VNYEPLGLEADMWSIGVITYILLSGASPFLG-DTKQETLANVSAVN-------------- 233 Query: 295 RPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQ 354 +E D + S +DF+ + L+K+P +R ++ Sbjct: 234 ----------------YEFEDEYFSN---------TSALAKDFIRRLLVKDPKKRMTIQD 268 Query: 355 LMVHAFIKRSDAEEVDFAGW 374 + H +IK D ++ + W Sbjct: 269 SLQHPWIKPKDTQQALSSAW 288 >3ZUT-A nrPDB Length = 362 Score = 247 bits (630), Expect = 7e-66, Method: Composition-based stats. Identities = 75/308 (24%), Positives = 130/308 (42%), Gaps = 45/308 (14%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPY 125 D +E + ++G+GN GV + K S ++A K I E I + RE+ P Sbjct: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYI--ERGEKIDENVKREIINHRSLRHPN 76 Query: 126 IVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHK 185 IV F + ++I ME+ GG L + + AGR E +I G++Y + Sbjct: 77 IVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAM-Q 135 Query: 186 IMHRDVKPSNILVNSR--GEIKLCDFGVSG-QLIDSMANSFVGTRSYMSPERLQGTHYSV 242 + HRD+K N L++ +K+C FG S ++ S S VGT +Y++PE L Y Sbjct: 136 VCHRDLKLENTLLDGSPAPRLKICAFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDG 195 Query: 243 QS-DIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYG 301 + D+WS G++L M VG YP P+ P + Sbjct: 196 KVADVWSCGVTLYVMLVGAYPFEDPE---------------------------EPKNFRK 228 Query: 302 MDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFI 361 R + + DY+ S E + +++ + +PA+R + ++ H + Sbjct: 229 TIHRILNVQYAIPDYV-----------HISPECRHLISRIFVADPAKRISIPEIRNHEWF 277 Query: 362 KRSDAEEV 369 ++ ++ Sbjct: 278 LKNLPADL 285 >2HAK-A nrPDB Length = 328 Score = 247 bits (630), Expect = 7e-66, Method: Composition-based stats. Identities = 57/214 (26%), Positives = 104/214 (48%), Gaps = 4/214 (1%) Query: 62 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHL-EIKPAIRNQIIRELQVLHE 120 + ++ +G GN V H +G +A K+I ++ P ++ RE++++ Sbjct: 11 QPHIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKI 70 Query: 121 CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL 180 N P IV + ++ + + ME+ GG + L GR+ E+ ++ + Y Sbjct: 71 LNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYC 130 Query: 181 REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL-IDSMANSFVGTRSYMSPERLQGTH 239 +K I+HRD+K N+L++ IK+ DFG S + + + ++F G+ Y +PE QG Sbjct: 131 HQK-YIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKK 189 Query: 240 YS-VQSDIWSMGLSLVEMAVGRYPIPPPDAKELE 272 Y + D+WS+G+ L + G P + KEL Sbjct: 190 YDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELR 223 >1G3N-A nrPDB Length = 326 Score = 246 bits (629), Expect = 9e-66, Method: Composition-based stats. Identities = 85/315 (26%), Positives = 137/315 (43%), Gaps = 32/315 (10%) Query: 64 KDDDFEKISELGAGNGGVVFKVSH-KPSGLVMARKLIHLEI-KPAIRNQIIRELQVLHEC 121 D +E ++E+G G G VFK K G +A K + ++ + + IRE+ VL Sbjct: 9 ADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHL 68 Query: 122 N---SPYIVGFYGAFY-----SDGEISICMEHMDGGSLDQVLKKAGR--IPEQILGKVSI 171 P +V + + ++++ EH+D L L K +P + + + Sbjct: 69 ETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMF 127 Query: 172 AVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA-NSFVGTRSYM 230 +++GL +L H+++HRD+KP NILV S G+IKL DFG++ MA S V T Y Sbjct: 128 QLLRGLDFLHS-HRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYR 186 Query: 231 SPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRP 290 +PE L + Y+ D+WS+G EM R P+ + +L V G E P Sbjct: 187 APEVLLQSSYATPVDLWSVGCIFAEM-FRRKPLFRGSSDVDQLGKILDVIGLPGEE-DWP 244 Query: 291 RTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERA 350 R P ++ S P+ F +D + KCL NPA+R Sbjct: 245 RDVALPRQAFHSKSAQPIEKFVTD---------------IDELGKDLLLKCLTFNPAKRI 289 Query: 351 DLKQLMVHAFIKRSD 365 + H + + + Sbjct: 290 SAYSALSHPYFQDLE 304 >1V0B-A nrPDB Length = 288 Score = 246 bits (629), Expect = 9e-66, Method: Composition-based stats. Identities = 77/305 (25%), Positives = 129/305 (42%), Gaps = 23/305 (7%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEI-KPAIRNQIIRELQVLHECNSP 124 + + + ++G G GVV+K + G A K I LE I + IRE+ +L E Sbjct: 2 EKYHGLEKIGEGTYGVVYKAQN-NYGETFALKKIRLEKEDEGIPSTTIREISILKELKHS 60 Query: 125 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKA-GRIPEQILGKVSIAVIKGLTYLREK 183 IV Y ++ + + EH+D L ++L G + + ++ G+ Y ++ Sbjct: 61 NIVKLYDVIHTKKRLVLVFEHLDQ-DLKKLLDVCEGGLESVTAKSFLLQLLNGIAYCHDR 119 Query: 184 HKIMHRDVKPSNILVNSRGEIKLCDFGVSGQ--LIDSMANSFVGTRSYMSPERLQG-THY 240 +++HRD+KP N+L+N GE+K+ DFG++ + V T Y +P+ L G Y Sbjct: 120 -RVLHRDLKPQNLLINREGELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVLMGSKKY 178 Query: 241 SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY 300 S DIWS+G EM G P ++ +LM ++ G P P Sbjct: 179 STTIDIWSVGCIFAEMVNGAPLFPGV-SEADQLMRIFRILGTPNSK-NWPNVTELPKYDP 236 Query: 301 GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF 360 P+ L D ++K L +P +R KQ + HA+ Sbjct: 237 NFTVYEPLPWESFLK-------------GLDESGIDLLSKMLKLDPNQRITAKQALEHAY 283 Query: 361 IKRSD 365 K ++ Sbjct: 284 FKENN 288 >2J90-A nrPDB Length = 304 Score = 246 bits (629), Expect = 1e-65, Method: Composition-based stats. Identities = 69/310 (22%), Positives = 126/310 (40%), Gaps = 51/310 (16%) Query: 63 LKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIR-----NQIIRELQV 117 + +D +E ELG+G +V K K +G A K I + R +I RE+ + Sbjct: 23 MVEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNI 82 Query: 118 LHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGL 177 L E P I+ + F + ++ + +E + GG L L + + E + ++ G+ Sbjct: 83 LREIRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDGV 142 Query: 178 TYLREKHKIMHRDVKPSNILVNSRG----EIKLCDFGVSGQLI-DSMANSFVGTRSYMSP 232 YL K +I H D+KP NI++ + IKL DFG++ ++ + + GT +++P Sbjct: 143 HYLHSK-RIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFVAP 201 Query: 233 ERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRT 292 E + +++D+WS+G+ + G P +E Sbjct: 202 EIVNYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISA--------------- 246 Query: 293 PGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADL 352 VN + S +DF+ + L+K+P R + Sbjct: 247 -------------------------VNYDFDEEYFSNTSELAKDFIRRLLVKDPKRRMTI 281 Query: 353 KQLMVHAFIK 362 Q + H++IK Sbjct: 282 AQSLEHSWIK 291 >4RGJ-A nrPDB Length = 520 Score = 246 bits (628), Expect = 1e-65, Method: Composition-based stats. Identities = 67/313 (21%), Positives = 126/313 (40%), Gaps = 49/313 (15%) Query: 63 LKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE--IKPAIRNQIIRELQVLHE 120 + ++ ++ I LG G+ G V K +G A K+I + + + ++RE+++L Sbjct: 57 VFNEQYKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKESLLREVELLKM 116 Query: 121 CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL 180 + I+ Y F + + + GG L + R E ++ ++ G+TY+ Sbjct: 117 LDHINIMKLYEFFEDNNYYYLVSDVYTGGELFDEIISRKRFYEIDAARIIKQILSGITYM 176 Query: 181 REKHKIMHRDVKPSNILV----NSRGEIKLCDFGVSGQL-IDSMANSFVGTRSYMSPERL 235 K+ ++HRD+KP NIL+ IK+ DFG+S +GT Y++P+ L Sbjct: 177 H-KNNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHFEYSKKMKDKIGTAYYIAPDVL 235 Query: 236 QGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGR 295 GT Y + DIWS G+ L + G P + E +++ + + P + Sbjct: 236 HGT-YDEKCDIWSCGVILYILLSGCPPFNG--SNEYDILKKVEAGKYTFDLPQFKK---- 288 Query: 296 PLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQL 355 S + +D + K L+ A R + Sbjct: 289 ----------------------------------ISDKAKDLIKKMLMYTSAVRISARDA 314 Query: 356 MVHAFIKRSDAEE 368 + H +IK +++ Sbjct: 315 LEHEWIKMMTSKD 327 >3Q53-A nrPDB Length = 306 Score = 246 bits (627), Expect = 2e-65, Method: Composition-based stats. Identities = 81/322 (25%), Positives = 148/322 (45%), Gaps = 51/322 (15%) Query: 43 DEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE 102 DE+ ++L + ++ VG+ K + + ++G G G V+ +G +A + ++L+ Sbjct: 3 DEEILEKLRSIVS----VGDPK-KKYTRFEKIGQGASGTVYTAMDVATGQEVAIRQMNLQ 57 Query: 103 IKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIP 162 +P + II E+ V+ E +P IV + ++ E+ + ME++ GGSL V+ + + Sbjct: 58 QQPK-KELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETC-MD 115 Query: 163 EQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMAN- 221 E + V ++ L +L ++++HRD+K NIL+ G +KL DFG Q+ + Sbjct: 116 EGQIAAVCRECLQALEFLHS-NQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKR 174 Query: 222 -SFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVE 280 + VGT +M+PE + Y + DIWS+G+ +EM G P Sbjct: 175 STMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPY----------------- 217 Query: 281 GDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNK 340 ++ P A++ + N P S F+DF+N+ Sbjct: 218 ---------------------LNENPLRALYLI---ATNGTPELQNPEKLSAIFRDFLNR 253 Query: 341 CLIKNPAERADLKQLMVHAFIK 362 CL + +R K+L+ H F+K Sbjct: 254 CLEMDVEKRGSAKELIQHQFLK 275 >2UV2-A nrPDB Length = 325 Score = 246 bits (627), Expect = 2e-65, Method: Composition-based stats. Identities = 94/317 (29%), Positives = 147/317 (46%), Gaps = 52/317 (16%) Query: 62 ELKDDDF-EKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE 120 +L +DF E I ELG G G V+K +K + ++ A K+I + + + + ++ E+ +L Sbjct: 32 DLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMV-EIDILAS 90 Query: 121 CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQV-LKKAGRIPEQILGKVSIAVIKGLTY 179 C+ P IV AFY + + I +E GG++D V L+ + E + V + L Y Sbjct: 91 CDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNY 150 Query: 180 LREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS--MANSFVGTRSYMSPERLQ- 236 L + +KI+HRD+K NIL G+IKL DFGVS + + +SF+GT +M+PE + Sbjct: 151 LHD-NKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMC 209 Query: 237 ----GTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRT 292 Y ++D+WS+G++L+EMA P EL M Sbjct: 210 ETSKDRPYDYKADVWSLGITLIEMAEIEPP-----HHELNPMRV---------------- 248 Query: 293 PGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADL 352 LL +EPP +S F+DF+ KCL KN R Sbjct: 249 --------------------LLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTT 288 Query: 353 KQLMVHAFIKRSDAEEV 369 QL+ H F+ + + Sbjct: 289 SQLLQHPFVTVDSNKPI 305 >3H4J-B nrPDB Length = 336 Score = 246 bits (627), Expect = 2e-65, Method: Composition-based stats. Identities = 64/304 (21%), Positives = 121/304 (39%), Gaps = 50/304 (16%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEI--KPAIRNQIIRELQVLHECNSPY 125 + LG G+ G V +H + +A K I ++ K + ++ RE+ L P+ Sbjct: 11 YIIRETLGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREISYLKLLRHPH 70 Query: 126 IVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHK 185 I+ Y + +I + +E+ GG L + + R+ E + +I + Y +HK Sbjct: 71 IIKLYDVITTPTDIVMVIEYA-GGELFDYIVEKKRMTEDEGRRFFQQIICAIEYCH-RHK 128 Query: 186 IMHRDVKPSNILVNSRGEIKLCDFGVSGQLID-SMANSFVGTRSYMSPERLQGTHY-SVQ 243 I+HRD+KP N+L++ +K+ DFG+S + D + + G+ +Y +PE + G Y + Sbjct: 129 IVHRDLKPENLLLDDNLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVINGKLYAGPE 188 Query: 244 SDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMD 303 D+WS G+ L M VGR P E +V P Sbjct: 189 VDVWSCGIVLYVMLVGRLPF----DDEFIPNLFKKVNSCVYVMPDF-------------- 230 Query: 304 SRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKR 363 S Q + + ++ +P +R ++++ + Sbjct: 231 --------------------------LSPGAQSLIRRMIVADPMQRITIQEIRRDPWFNV 264 Query: 364 SDAE 367 + + Sbjct: 265 NLPD 268 >6C9D-A nrPDB Length = 459 Score = 245 bits (626), Expect = 2e-65, Method: Composition-based stats. Identities = 57/214 (26%), Positives = 103/214 (48%), Gaps = 4/214 (1%) Query: 62 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHL-EIKPAIRNQIIRELQVLHE 120 + ++ +G GN V H +G +A K+I ++ P ++ RE++++ Sbjct: 17 QPHIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKI 76 Query: 121 CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL 180 N P IV + ++ + + ME+ GG + L GR+ E+ ++ + Y Sbjct: 77 LNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYC 136 Query: 181 REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL-IDSMANSFVGTRSYMSPERLQGTH 239 +K I+HRD+K N+L++ IK+ DFG S + + + + F G+ Y +PE QG Sbjct: 137 HQK-YIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDEFCGSPPYAAPELFQGKK 195 Query: 240 YS-VQSDIWSMGLSLVEMAVGRYPIPPPDAKELE 272 Y + D+WS+G+ L + G P + KEL Sbjct: 196 YDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELR 229 >4JXF-A nrPDB Length = 266 Score = 245 bits (626), Expect = 2e-65, Method: Composition-based stats. Identities = 73/310 (23%), Positives = 131/310 (42%), Gaps = 51/310 (16%) Query: 60 VGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE--IKPAIRNQIIRELQV 117 +GE K +DF+ + LG G+ V++ +GL +A K+I + K + ++ E+++ Sbjct: 2 IGE-KIEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKI 60 Query: 118 LHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKA-GRIPEQILGKVSIAVIKG 176 + P I+ Y F + + +E G +++ LK E +I G Sbjct: 61 HCQLKHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITG 120 Query: 177 LTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL--IDSMANSFVGTRSYMSPER 234 + YL H I+HRD+ SN+L+ IK+ DFG++ QL + GT +Y+SPE Sbjct: 121 MLYLHS-HGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEI 179 Query: 235 LQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPG 294 + + ++SD+WS+G + +GR P D ++ V D Sbjct: 180 ATRSAHGLESDVWSLGCMFYTLLIGRPPF---DTDTVKNTLNKVVLADYEM--------- 227 Query: 295 RPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQ 354 S+E +D +++ L +NPA+R L Sbjct: 228 --------------------------------PSFLSIEAKDLIHQLLRRNPADRLSLSS 255 Query: 355 LMVHAFIKRS 364 ++ H F+ R+ Sbjct: 256 VLDHPFMSRN 265 >5Z33-A nrPDB Length = 425 Score = 244 bits (624), Expect = 3e-65, Method: Composition-based stats. Identities = 69/312 (22%), Positives = 128/312 (41%), Gaps = 28/312 (8%) Query: 63 LKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLI-HLEIKPAIRNQIIRELQVLHEC 121 + D+ + ELG G G+V + + +A K + ++ K + + +RE+++L Sbjct: 28 IVDERYTVTKELGQGAYGIVCAAVNNQTSEGVAIKKVTNVFSKKILAKRALREIKLLQHF 87 Query: 122 N-SPYIVGFYGAFYSD----GEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKG 176 I Y E + E M+ L +++ + + ++ G Sbjct: 88 RGHRNITCLYDMDIPRPDNFNETYLYEELMEC-DLAAIIRSGQPLTDAHFQSFIYQILCG 146 Query: 177 LTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSG------QLIDSMANSFVGTRSYM 230 L Y+ + ++HRD+KP N+LVN+ E+K+CDFG++ + +V TR Y Sbjct: 147 LKYIHSAN-VLHRDLKPGNLLVNADCELKICDFGLARGFSVDPEENAGYMTEYVATRWYR 205 Query: 231 SPE-RLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPR 289 +PE L Y+ D+WS+G L E+ G P +L + G E Sbjct: 206 APEIMLSFQSYTKAIDVWSVGCILAELL-GGRPFFKGRDYVDQLNQILHILGTPNEET-- 262 Query: 290 PRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAER 349 G P + + + P MA N P + D +++ L +P+ R Sbjct: 263 LSRIGSPRAQEYVRNLPFMAKKPFPTLFPNANP----------DALDLLDRMLAFDPSSR 312 Query: 350 ADLKQLMVHAFI 361 ++Q + H ++ Sbjct: 313 ISVEQALEHPYL 324 >5F9E-A nrPDB Length = 353 Score = 244 bits (623), Expect = 5e-65, Method: Composition-based stats. Identities = 74/315 (23%), Positives = 129/315 (40%), Gaps = 51/315 (16%) Query: 62 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEI---KPAIRNQIIRELQVL 118 +LK +DFE LG G+ G VF K + A K + ++ + ++ + + Sbjct: 15 KLKIEDFELHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLS 74 Query: 119 HECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLT 178 P++ + F + + ME+++GG L ++ + + +I GL Sbjct: 75 LAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQ 134 Query: 179 YLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQ--LIDSMANSFVGTRSYMSPERLQ 236 +L K I++RD+K NIL++ G IK+ DFG+ + L D+ N F GT Y++PE L Sbjct: 135 FLHSK-GIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNEFCGTPDYIAPEILL 193 Query: 237 GTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRP 296 G Y+ D WS G+ L EM +G+ P D +EL + P PR Sbjct: 194 GQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSI-------RMDNPFYPRW---- 242 Query: 297 LSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLK-QL 355 E +D + K ++ P +R ++ + Sbjct: 243 ---------------------------------LEKEAKDLLVKLFVREPEKRLGVRGDI 269 Query: 356 MVHAFIKRSDAEEVD 370 H + + EE++ Sbjct: 270 RQHPLFREINWEELE 284 >3UDB-A nrPDB Length = 317 Score = 244 bits (623), Expect = 5e-65, Method: Composition-based stats. Identities = 75/308 (24%), Positives = 130/308 (42%), Gaps = 45/308 (14%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPY 125 D +E + ++GAGN GV + K + ++A K I E I + RE+ P Sbjct: 19 DRYELVKDIGAGNFGVARLMRDKQANELVAVKYI--ERGEKIDENVKREIINHRSLRHPN 76 Query: 126 IVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHK 185 IV F + ++I ME+ GG L + + AGR E +I G++Y + Sbjct: 77 IVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYAHAM-Q 135 Query: 186 IMHRDVKPSNILVNSR--GEIKLCDFGVSG-QLIDSMANSFVGTRSYMSPERLQGTHYSV 242 + HRD+K N L++ +K+ DFG S ++ S S VGT +Y++PE L Y Sbjct: 136 VAHRDLKLENTLLDGSPAPRLKIADFGYSKASVLHSQPKSAVGTPAYIAPEVLLKKEYDG 195 Query: 243 QS-DIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYG 301 + D+WS G++L M VG YP P+ P + Sbjct: 196 KVADVWSCGVTLYVMLVGAYPFEDPE---------------------------EPKNFRK 228 Query: 302 MDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFI 361 R + + DY+ S E + +++ + +PA+R + ++ H + Sbjct: 229 TIHRILNVQYAIPDYV-----------HISPECRHLISRIFVADPAKRISIPEIRNHEWF 277 Query: 362 KRSDAEEV 369 ++ ++ Sbjct: 278 LKNLPADL 285 >2YAB-A nrPDB Length = 361 Score = 244 bits (622), Expect = 5e-65, Method: Composition-based stats. Identities = 72/329 (21%), Positives = 132/329 (40%), Gaps = 57/329 (17%) Query: 50 LEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIR- 108 +E F QK +D ++ ELG+G +V K K +GL A K I A R Sbjct: 2 METFKQQKV------EDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRR 55 Query: 109 ----NQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQ 164 +I RE+ +L + P I+ + + + ++ + +E + GG L L + + E+ Sbjct: 56 GVCREEIEREVSILRQVLHPNIITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEE 115 Query: 165 ILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRG----EIKLCDFGVSGQLIDS-M 219 ++ G+ YL K KI H D+KP NI++ + IKL DFG++ ++ D Sbjct: 116 EATSFIKQILDGVNYLHTK-KIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVE 174 Query: 220 ANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQV 279 + GT +++PE + +++D+WS+G+ + G P +E Sbjct: 175 FKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITA-- 232 Query: 280 EGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVN 339 V+ + S +DF+ Sbjct: 233 --------------------------------------VSYDFDEEFFSQTSELAKDFIR 254 Query: 340 KCLIKNPAERADLKQLMVHAFIKRSDAEE 368 K L+K +R +++ + H +I D ++ Sbjct: 255 KLLVKETRKRLTIQEALRHPWITPVDTQQ 283 >1UA2-A nrPDB Length = 346 Score = 244 bits (622), Expect = 6e-65, Method: Composition-based stats. Identities = 83/308 (26%), Positives = 134/308 (43%), Gaps = 26/308 (8%) Query: 64 KDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHL----EIKPAIRNQIIRELQVLH 119 + +EK+ LG G V+K K + ++A K I L E K I +RE+++L Sbjct: 8 RAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQ 67 Query: 120 ECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAG-RIPEQILGKVSIAVIKGLT 178 E + P I+G AF IS+ + M+ L+ ++K + + + ++GL Sbjct: 68 ELSHPNIIGLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLMTLQGLE 126 Query: 179 YLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL--IDSMANSFVGTRSYMSPERLQ 236 YL +H I+HRD+KP+N+L++ G +KL DFG++ + V TR Y +PE L Sbjct: 127 YLH-QHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLF 185 Query: 237 GTH-YSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGR 295 G Y V D+W++G L E+ + R P P D+ +L + G TP + P Sbjct: 186 GARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETLG----TPTEEQWP-- 238 Query: 296 PLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQL 355 M S P F+ I P + D + + NP R Q Sbjct: 239 -----DMCSLPDYVTFKSFPGI----PLHHIFSAAGDDLLDLIQGLFLFNPCARITATQA 289 Query: 356 MVHAFIKR 363 + + Sbjct: 290 LKMKYFSN 297 >5G6V-A nrPDB Length = 324 Score = 243 bits (620), Expect = 9e-65, Method: Composition-based stats. Identities = 78/300 (26%), Positives = 130/300 (43%), Gaps = 20/300 (6%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPY 125 + + K+ +LG G V+K K + ++A K I LE + IRE+ +L + Sbjct: 2 ETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHAN 61 Query: 126 IVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR-IPEQILGKVSIAVIKGLTYLREKH 184 IV + +++ +++ E++D L Q L G I + +++GL Y + Sbjct: 62 IVTLHDIIHTEKSLTLVFEYLDK-DLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCH-RQ 119 Query: 185 KIMHRDVKPSNILVNSRGEIKLCDFGVSG--QLIDSMANSFVGTRSYMSPERLQGT-HYS 241 K++HRD+KP N+L+N RGE+KL DFG++ + ++ V T Y P+ L G+ YS Sbjct: 120 KVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYDNEVVTLWYRPPDILLGSTDYS 179 Query: 242 VQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYG 301 Q D+W +G EMA GR P+ P E +L F ++ G E +Y Sbjct: 180 TQIDMWGVGCIFYEMATGR-PLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYN 238 Query: 302 MDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFI 361 A+ + ++ D + K L R + M H F Sbjct: 239 YPKYRAEALLSHAPRLDSDGA-------------DLLTKLLQFEGRNRISAEDAMKHPFF 285 >4CQG-A nrPDB Length = 331 Score = 243 bits (620), Expect = 1e-64, Method: Composition-based stats. Identities = 63/315 (20%), Positives = 121/315 (38%), Gaps = 52/315 (16%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIV 127 +E +G G V H +G ++A K++ + ++ E+ L +I Sbjct: 11 YELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGSDLPRVKTEIDALKSLRHQHIC 70 Query: 128 GFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIM 187 Y + +I + +E+ GG L + R+ E+ V ++ + Y+ + Sbjct: 71 QLYHVLETKNKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQILSAVAYVHSQ-GYA 129 Query: 188 HRDVKPSNILVNSRGEIKLCDFGVSGQ---LIDSMANSFVGTRSYMSPERLQGTHY-SVQ 243 HRD+KP N+L + ++KL DFG+ + D G+ +Y +PE +QG Y + Sbjct: 130 HRDLKPENLLFDENHKLKLIDFGLCAKPKGNKDYHLQECCGSLAYAAPELIQGKSYLGSE 189 Query: 244 SDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMD 303 +D+WSMG+ L + G P + Sbjct: 190 ADVWSMGILLYVLMCGFLPFDDDNV----------------------------------- 214 Query: 304 SRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKR 363 MA+++ + E P L S + + L +P +R ++ L+ H ++ + Sbjct: 215 ----MALYKKIMRGKYEVPKWL-----SPSSILLLQQMLQVDPKKRISMRNLLNHPWVMQ 265 Query: 364 SDAEEVDFAGWLCST 378 + V+ W T Sbjct: 266 DYSCPVE---WQSKT 277 >4D28-A nrPDB Length = 446 Score = 243 bits (619), Expect = 1e-64, Method: Composition-based stats. Identities = 69/302 (22%), Positives = 120/302 (39%), Gaps = 50/302 (16%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIR--NQIIRELQVLHECNSPY 125 +E +G G V + +G +A K++ R +QI RE+ ++ P Sbjct: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 Query: 126 IVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHK 185 IV Y S +I I +E + GG L + GR+ E K ++ + + K Sbjct: 71 IVRLYEVLASKSKIYIVLEFVTGGELFDRIVHKGRLKEDESRKYFQQLVDAVAHCHSK-G 129 Query: 186 IMHRDVKPSNILVNSRGEIKLCDFGVSGQLID--SMANSFVGTRSYMSPERLQGTHYS-V 242 + HRD+KP N+L+++ G +K+ DFG+S + + N GT +Y++PE L G Y Sbjct: 130 VYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLNDTCGTPNYVAPEVLSGQGYDGS 189 Query: 243 QSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGM 302 +DIWS G+ L + G P D L ++ + PP Sbjct: 190 AADIWSCGVILFVILAGYLPFSETDLPGLYR----KINAAEFDCPPW------------- 232 Query: 303 DSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIK 362 FS E + +++ L NP R ++ + + + Sbjct: 233 ---------------------------FSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFR 265 Query: 363 RS 364 ++ Sbjct: 266 KN 267 >3OZ6-A nrPDB Length = 388 Score = 243 bits (619), Expect = 1e-64, Method: Composition-based stats. Identities = 73/326 (22%), Positives = 133/326 (40%), Gaps = 34/326 (10%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIR-NQIIRELQVLHECN-SPY 125 +E + +LG G G+V+K + +G V+A K I + + + RE+ +L E + Sbjct: 11 YELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIFDAFQNSTDAQRTFREIMILTELSGHEN 70 Query: 126 IVGFYGAFYSDGE--ISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREK 183 IV +D + + + ++M+ L V++ A + V +IK + YL Sbjct: 71 IVNLLNVLRADNDRDVYLVFDYMET-DLHAVIR-ANILEPVHKQYVVYQLIKVIKYLHS- 127 Query: 184 HKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID-----------------------SMA 220 ++HRD+KPSNIL+N+ +K+ DFG+S ++ + Sbjct: 128 GGLLHRDMKPSNILLNAECHVKVADFGLSRSFVNIRRVTNNIPLSINENTENFDDDQPIL 187 Query: 221 NSFVGTRSYMSPERLQGT-HYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQV 279 +V TR Y +PE L G+ Y+ D+WS+G L E+ G+ P + Sbjct: 188 TDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGKPIFPGSSTMNQLERIIGVI 247 Query: 280 EGDAAETPPRPRTPGRPLSSYGMDSR---PPMAIFELLDYIVNEPPPKLPSGVFSLEFQD 336 + + E ++P + + ++ N P + E D Sbjct: 248 DFPSNEDVESIQSPFAKTMIESLKEKVEIRQSNKRDIFTKWKNLLLKINPKADCNEEALD 307 Query: 337 FVNKCLIKNPAERADLKQLMVHAFIK 362 ++K L NP +R + H F+ Sbjct: 308 LLDKLLQFNPNKRISANDALKHPFVS 333 >4D2V-A nrPDB Length = 356 Score = 243 bits (619), Expect = 2e-64, Method: Composition-based stats. Identities = 64/323 (19%), Positives = 116/323 (35%), Gaps = 49/323 (15%) Query: 55 TQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRE 114 K + +E +G G V H +G ++A K++ + +I E Sbjct: 18 GSHMKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTE 77 Query: 115 LQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVI 174 ++ L +I Y + +I + +E+ GG L + R+ E+ V ++ Sbjct: 78 IEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIV 137 Query: 175 KGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQ---LIDSMANSFVGTRSYMS 231 + Y+ + HRD+KP N+L + ++KL DFG+ + D + G +Y + Sbjct: 138 SAVAYVHSQ-GYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQACCGALAYAA 196 Query: 232 PERLQGTHY-SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRP 290 PE +QG Y ++D+WSMG+ L + G P A L Sbjct: 197 PELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDTAAAL------------------- 237 Query: 291 RTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERA 350 G P S + + L +P +R Sbjct: 238 ----VAKIMRGKYDVPKW---------------------LSPSSILLLQQMLQVDPKKRI 272 Query: 351 DLKQLMVHAFIKRSDAEEVDFAG 373 +K L+ H +I + V++ Sbjct: 273 SMKNLLNHPWIMQDYNYPVEWQS 295 >4NIF-A nrPDB Length = 333 Score = 242 bits (618), Expect = 2e-64, Method: Composition-based stats. Identities = 69/307 (22%), Positives = 120/307 (39%), Gaps = 50/307 (16%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVL-HECNSP 124 D + +G G+ + HK + + A K+I + E+++L P Sbjct: 8 DGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSE-----EIEILLRYGQHP 62 Query: 125 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKH 184 I+ + + + E M GG L + + E+ V + K + YL + Sbjct: 63 NIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQ- 121 Query: 185 KIMHRDVKPSNIL-VNSRGE---IKLCDFGVSGQL--IDSMANSFVGTRSYMSPERLQGT 238 ++HRD+KPSNIL V+ G +++CDFG + QL + + + T ++++PE L+ Sbjct: 122 GVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQ 181 Query: 239 HYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLS 298 Y DIWS+G+ L M G P + E + Sbjct: 182 GYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEIL----------------------- 218 Query: 299 SYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVH 358 +R F L N S +D V+K L +P +R KQ++ H Sbjct: 219 -----TRIGSGKFTLSGGNWN---------TVSETAKDLVSKMLHVDPHQRLTAKQVLQH 264 Query: 359 AFIKRSD 365 ++ + D Sbjct: 265 PWVTQKD 271 >4RLP-A nrPDB Length = 288 Score = 242 bits (618), Expect = 2e-64, Method: Composition-based stats. Identities = 79/321 (24%), Positives = 137/321 (42%), Gaps = 58/321 (18%) Query: 62 ELKDDDFEKISELGAGNGGVVFKVSHK---PSGLVMARKLIHLEI---KPAIRNQIIREL 115 +++ + FE + LG G G VF+V +G + A K++ + E Sbjct: 1 KIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAER 60 Query: 116 QVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIK 175 +L E P+IV AF + G++ + +E++ GG L L++ G E + Sbjct: 61 NILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISM 120 Query: 176 GLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS--MANSFVGTRSYMSPE 233 L +L +K I++RD+KP NI++N +G +KL DFG+ + I + ++F GT YM+PE Sbjct: 121 ALGHLHQK-GIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPE 179 Query: 234 RLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTP 293 L + ++ D WS+G + +M G P + K+ Sbjct: 180 ILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKK----------------------- 216 Query: 294 GRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERA--- 350 I ++L +N PP + E +D + K L +N A R Sbjct: 217 ---------------TIDKILKCKLNLPP------YLTQEARDLLKKLLKRNAASRLGAG 255 Query: 351 --DLKQLMVHAFIKRSDAEEV 369 D ++ H F + + EE+ Sbjct: 256 PGDAGEVQAHPFFRHINWEEL 276 >4L42-A nrPDB Length = 346 Score = 242 bits (618), Expect = 2e-64, Method: Composition-based stats. Identities = 79/321 (24%), Positives = 137/321 (42%), Gaps = 58/321 (18%) Query: 62 ELKDDDFEKISELGAGNGGVVFKVSHK---PSGLVMARKLIHLEI---KPAIRNQIIREL 115 +++ + FE + LG G G VF+V +G + A K++ + E Sbjct: 14 KIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAER 73 Query: 116 QVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIK 175 +L E P+IV AF + G++ + +E++ GG L L++ G E + Sbjct: 74 NILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISM 133 Query: 176 GLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS--MANSFVGTRSYMSPE 233 L +L +K I++RD+KP NI++N +G +KL DFG+ + I + ++F GT YM+PE Sbjct: 134 ALGHLHQK-GIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPE 192 Query: 234 RLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTP 293 L + ++ D WS+G + +M G P + K+ Sbjct: 193 ILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKK----------------------- 229 Query: 294 GRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERA--- 350 I ++L +N PP + E +D + K L +N A R Sbjct: 230 ---------------TIDKILKCKLNLPP------YLTQEARDLLKKLLKRNAASRLGAG 268 Query: 351 --DLKQLMVHAFIKRSDAEEV 369 D ++ H F + + EE+ Sbjct: 269 PGDAGEVQAHPFFRHINWEEL 289 >4WNO-A nrPDB Length = 287 Score = 242 bits (618), Expect = 2e-64, Method: Composition-based stats. Identities = 69/306 (22%), Positives = 119/306 (38%), Gaps = 53/306 (17%) Query: 67 DFEKISELGAGNGGVVFKVSHKP-SGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPY 125 +F + +G G VVFK H+ L +A K I+ + + + +E+++L E Sbjct: 19 EFSRKDLIGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHEN 78 Query: 126 IVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHK 185 IV Y + + ME+ +GG L L + E + + + L K Sbjct: 79 IVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSK-G 137 Query: 186 IMHRDVKPSNILVNSRG---------EIKLCDFGVSGQLIDS-MANSFVGTRSYMSPERL 235 I+HRD+KP NIL+++ +K+ DFG + L + MA + G+ YM+PE + Sbjct: 138 IIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVI 197 Query: 236 QGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGR 295 HY ++D+WS+G + + G+ P ++L L + E + P PR Sbjct: 198 MSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFY----EKNKTLVPTIPRETSA 253 Query: 296 PLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQL 355 PL + +N +R D + Sbjct: 254 PLRQLLLALL-------------------------------------QRNHKDRMDFDEF 276 Query: 356 MVHAFI 361 H F+ Sbjct: 277 FHHPFL 282 >6E9W-A nrPDB Length = 443 Score = 242 bits (618), Expect = 2e-64, Method: Composition-based stats. Identities = 77/259 (29%), Positives = 125/259 (48%), Gaps = 22/259 (8%) Query: 25 SAETNLEALQKKLEELELDE-----QQRKRLEAFLTQ------KQKVGELKDDDFEKISE 73 +E N + L L+ L D ++ K ++ FL++ K + +K +D+E + Sbjct: 50 KSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINKIRDLRMKAEDYEVVKV 109 Query: 74 LGAGNGGVVFKVSHKPSGLVMARKLIHLE--IKPAIRNQIIRELQVLHECNSPYIVGFYG 131 +G G G V V HK + V A KL+ IK + E ++ NSP++V + Sbjct: 110 IGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFY 169 Query: 132 AFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDV 191 AF D + + ME+M GG L ++ +PE+ + V+ L + +HRDV Sbjct: 170 AFQDDRYLYMVMEYMPGGDLVNLMSNYD-VPEKWARFYTAEVVLALDAIHSM-GFIHRDV 227 Query: 192 KPSNILVNSRGEIKLCDFGVSGQLIDS---MANSFVGTRSYMSPERLQ----GTHYSVQS 244 KP N+L++ G +KL DFG ++ ++ VGT Y+SPE L+ +Y + Sbjct: 228 KPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYGREC 287 Query: 245 DIWSMGLSLVEMAVGRYPI 263 D WS+G+ L EM VG P Sbjct: 288 DWWSVGVFLYEMLVGDTPF 306 >4WB7-A nrPDB Length = 405 Score = 242 bits (618), Expect = 2e-64, Method: Composition-based stats. Identities = 73/331 (22%), Positives = 137/331 (41%), Gaps = 55/331 (16%) Query: 42 LDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHL 101 L + + L+ + + Q L D FE+I LG G+ G V V HK +G A K++ Sbjct: 74 LAKAKEDFLKKWESPAQNTAHL--DQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDK 131 Query: 102 E--IKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAG 159 + +K + E ++L N P++V +F + + + ME++ GG + L++ G Sbjct: 132 QKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIG 191 Query: 160 RIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSM 219 R E + ++ YL +++RD+KP N+L++ +G I++ DFG + ++ Sbjct: 192 RFSEPHARFYAAQIVLTFEYLHSL-DLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK-GR 249 Query: 220 ANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQV 279 + GT Y++PE + Y+ D W++G+ + EMA G P A + ++ V Sbjct: 250 TWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF---ADQPIQIYEKIV 306 Query: 280 EGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVN 339 G + PS FS + +D + Sbjct: 307 SGKV----------------------------------------RFPSH-FSSDLKDLLR 325 Query: 340 KCLIKNPAERA-----DLKQLMVHAFIKRSD 365 L + +R + + H + +D Sbjct: 326 NLLQVDLTKRFGNLKNGVNDIKNHKWFATTD 356 >2Y7J-A nrPDB Length = 365 Score = 242 bits (617), Expect = 2e-64, Method: Composition-based stats. Identities = 81/369 (21%), Positives = 140/369 (37%), Gaps = 70/369 (18%) Query: 19 AVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQ-KVGELKD--------DDFE 69 ++ S NL A KKL + Q K E Q EL D ++ Sbjct: 43 SLRDDPSQSANLLAEAKKLND-----AQPKGTENLYFQSMGPEDELPDWAAAKEFYQKYD 97 Query: 70 KISELGAGNGGVVFKVSHKPSGLVMARKL-------IHLEIKPAIRNQIIRELQVLHEC- 121 +G G VV + H+ +G A K+ + E +R RE +L + Sbjct: 98 PKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHILRQVA 157 Query: 122 NSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLR 181 P+I+ ++ S + + + M G L L + + E+ + ++++ +++L Sbjct: 158 GHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLEAVSFLH 217 Query: 182 EKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL-IDSMANSFVGTRSYMSPERLQGT-- 238 + I+HRD+KP NIL++ +I+L DFG S L GT Y++PE L+ + Sbjct: 218 -ANNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEPGEKLRELCGTPGYLAPEILKCSMD 276 Query: 239 ----HYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPG 294 Y + D+W+ G+ L + G P + LM +EG + P Sbjct: 277 ETHPGYGKEVDLWACGVILFTLLAGSPPFW---HRRQILMLRMIMEGQYQFSSPE----- 328 Query: 295 RPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQ 354 D R S +D +++ L +P R +Q Sbjct: 329 -------WDDR-------------------------SSTVKDLISRLLQVDPEARLTAEQ 356 Query: 355 LMVHAFIKR 363 + H F +R Sbjct: 357 ALQHPFFER 365 >3IS5-A nrPDB Length = 285 Score = 242 bits (617), Expect = 2e-64, Method: Composition-based stats. Identities = 72/308 (23%), Positives = 123/308 (39%), Gaps = 51/308 (16%) Query: 65 DDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSP 124 DD F +LG+G G V V + SGL K I+ + QI E++VL + P Sbjct: 21 DDLFIFKRKLGSGAFGDVHLVEERSSGLERVIKTINKDRSQVPMEQIEAEIEVLKSLDHP 80 Query: 125 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLK----KAGRIPEQILGKVSIAVIKGLTYL 180 I+ + F + I ME +GG L + + + + E + ++ ++ L Y Sbjct: 81 NIIKIFEVFEDYHNMYIVMETCEGGELLERIVSAQARGKALSEGYVAELMKQMMNALAYF 140 Query: 181 REKHKIMHRDVKPSNILVNS---RGEIKLCDFGVSGQL-IDSMANSFVGTRSYMSPERLQ 236 +H ++H+D+KP NIL IK+ DFG++ D + + GT YM+PE + Sbjct: 141 HSQH-VVHKDLKPENILFQDTSPHSPIKIIDFGLAELFKSDEHSTNAAGTALYMAPEVFK 199 Query: 237 GTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRP 296 + + DIWS G+ + + G P +E++ A P RP Sbjct: 200 -RDVTFKCDIWSAGVVMYFLLTGCLPFTGTSLEEVQQ--------KATYKEPNYAVECRP 250 Query: 297 LSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLM 356 L+ + D + + L K+P R Q++ Sbjct: 251 LT---------------------------------PQAVDLLKQMLTKDPERRPSAAQVL 277 Query: 357 VHAFIKRS 364 H + K++ Sbjct: 278 HHEWFKQA 285 >4CZT-A nrPDB Length = 464 Score = 242 bits (617), Expect = 3e-64, Method: Composition-based stats. Identities = 67/310 (21%), Positives = 121/310 (39%), Gaps = 52/310 (16%) Query: 61 GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE--IKPAIRNQIIRELQVL 118 G + +E LG G V + +G +A K+I E +K + QI RE+ + Sbjct: 6 GRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTM 65 Query: 119 HECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLT 178 P ++ + S +I +E + GG L + GR+ E K +I + Sbjct: 66 KLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVD 125 Query: 179 YLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQ----LIDSMANSFVGTRSYMSPER 234 Y + + HRD+KP N+L+++ G +K+ DFG+S D + ++ GT +Y++PE Sbjct: 126 YCHSR-GVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEV 184 Query: 235 LQGTHYS-VQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTP 293 + Y ++D+WS G+ L + G P + L ++ PP Sbjct: 185 INNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLY----KKIFKAEFTCPPW---- 236 Query: 294 GRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLK 353 FS + + + L NPA R Sbjct: 237 ------------------------------------FSASAKKLIKRILDPNPATRITFA 260 Query: 354 QLMVHAFIKR 363 +++ + + K+ Sbjct: 261 EVIENEWFKK 270 >1CM8-A nrPDB Length = 367 Score = 241 bits (616), Expect = 3e-64, Method: Composition-based stats. Identities = 69/309 (22%), Positives = 125/309 (40%), Gaps = 25/309 (8%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPA-IRNQIIRELQVLHECNSPYI 126 + + +G+G G V +G +A K ++ + + REL++L + Sbjct: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 Query: 127 VGFYGAFYSD------GEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL 180 +G F D + + M M G L +++K ++ E + + ++KGL Y+ Sbjct: 87 IGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMK-HEKLGEDRIQFLVYQMLKGLRYI 144 Query: 181 REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQG-TH 239 I+HRD+KP N+ VN E+K+ DFG++ Q DS +V TR Y +PE + Sbjct: 145 HAA-GIIHRDLKPGNLAVNEDCELKILDFGLARQ-ADSEMTGYVVTRWYRAPEVILNWMR 202 Query: 240 YSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSS 299 Y+ DIWS+G + EM G+ D + AE R ++ + Sbjct: 203 YTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSD---EAK 259 Query: 300 YGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHA 359 M P + + + N S + + K L+ + +R + + H Sbjct: 260 NYMKGLPELEKKDFASILTNA----------SPLAVNLLEKMLVLDAEQRVTAGEALAHP 309 Query: 360 FIKRSDAEE 368 + + E Sbjct: 310 YFESLHDTE 318 >6HXF-B nrPDB Length = 302 Score = 241 bits (616), Expect = 3e-64, Method: Composition-based stats. Identities = 93/311 (29%), Positives = 156/311 (50%), Gaps = 51/311 (16%) Query: 64 KDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNS 123 ++ +E + ELG G G V+K +K +G + A K+I + + + + I+ E+++L C+ Sbjct: 17 PNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIV-EIEILATCDH 75 Query: 124 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR-IPEQILGKVSIAVIKGLTYLRE 182 PYIV GA+Y DG++ I +E GG++D ++ + R + E + V +++ L +L Sbjct: 76 PYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHS 135 Query: 183 KHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMAN--SFVGTRSYMSPERLQ---- 236 K +I+HRD+K N+L+ G+I+L DFGVS + + ++ SF+GT +M+PE + Sbjct: 136 K-RIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETM 194 Query: 237 -GTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGR 295 T Y ++DIWS+G++L+EMA P EL M Sbjct: 195 KDTPYDYKADIWSLGITLIEMAQIEPP-----HHELNPMRV------------------- 230 Query: 296 PLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQL 355 LL ++PP L +S+EF+DF+ L KNP R QL Sbjct: 231 -----------------LLKIAKSDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQL 273 Query: 356 MVHAFIKRSDA 366 + H F+ + Sbjct: 274 LEHPFVSSITS 284 >6FDY-U nrPDB Length = 276 Score = 241 bits (616), Expect = 3e-64, Method: Composition-based stats. Identities = 70/306 (22%), Positives = 120/306 (39%), Gaps = 47/306 (15%) Query: 61 GELKDDDFEKISELGAGNGGVVFKVS-HKPSGLVMARKLI-HLEIKPAIRNQIIRELQVL 118 G + D F LG+G V+K K + V+A K + + A ++ E+++L Sbjct: 6 GPPRLDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEIL 65 Query: 119 HECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLT 178 P+IV + I + ME GG L + + +PE++ + L Sbjct: 66 KGIRHPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQ 125 Query: 179 YLREKHKIMHRDVKPSNILVN--SRGEIKLCDFGVSGQL-IDSMANSFVGTRSYMSPERL 235 +L E++ I H D+KP NIL++ + +KL DFG + + + G+ YM+PE + Sbjct: 126 FLHERN-ISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMV 184 Query: 236 QGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGR 295 Y + D+WSMG+ L E G+ P ELE E P RP Sbjct: 185 CQRQYDARVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSN---RVIELPLRP----- 236 Query: 296 PLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQL 355 + S + +D + + L ++P+ R + Sbjct: 237 ---------------------------------LLSRDCRDLLQRLLERDPSRRISFQDF 263 Query: 356 MVHAFI 361 H ++ Sbjct: 264 FAHPWV 269 >4BGQ-A nrPDB Length = 304 Score = 241 bits (615), Expect = 4e-64, Method: Composition-based stats. Identities = 76/301 (25%), Positives = 133/301 (44%), Gaps = 17/301 (5%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIH-LEIKPAIRNQIIRELQVLHECNSP 124 + FE + +G G GVV K HK + ++A K E ++ +REL++L Sbjct: 12 NKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQE 71 Query: 125 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKH 184 IV AF G++ + E+++ L+ + + +P + + +IK + + K+ Sbjct: 72 NIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCH-KN 130 Query: 185 KIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS---MANSFVGTRSYMSPERLQGTHYS 241 I+HRD+KP N+L++ +KLCDFG + L + + V TR Y SPE L G Y Sbjct: 131 DIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYDEEVATRWYRSPELLLGAPYG 190 Query: 242 VQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYG 301 D+WS+G L E++ G+ P+ P +++ +L +V G P Sbjct: 191 KSVDMWSVGCILGELSDGQ-PLFPGESEIDQLFTIQKVLG-----------PLPSEQMKL 238 Query: 302 MDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFI 361 S P + + G+ + D + L +PA+R +Q + H Sbjct: 239 FYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTF 298 Query: 362 K 362 + Sbjct: 299 Q 299 >3GC9-A nrPDB Length = 370 Score = 241 bits (614), Expect = 5e-64, Method: Composition-based stats. Identities = 73/317 (23%), Positives = 130/317 (41%), Gaps = 26/317 (8%) Query: 60 VGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIR-NQIIRELQVL 118 V E+ + + +G+G G V +A K + + I + REL++L Sbjct: 23 VWEVPQ-RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLL 81 Query: 119 HECNSPYIVGFYGAF------YSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIA 172 ++G F E+ + M G L+ ++K + ++ + + Sbjct: 82 KHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKSQ-ALSDEHVQFLVYQ 139 Query: 173 VIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSP 232 +++GL Y+ I+HRD+KPSN+ VN E+++ DFG++ Q D +V TR Y +P Sbjct: 140 LLRGLKYIHSA-GIIHRDLKPSNVAVNEDSELRILDFGLARQ-ADEEMTGYVATRWYRAP 197 Query: 233 E-RLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPR 291 E L HY+ DIWS+G + E+ G+ P D +L +V G +P Sbjct: 198 EIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYI-DQLKRIMEVVG--TPSPEVLA 254 Query: 292 TPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERAD 351 + + S PPM +L P D + + L+ + +R Sbjct: 255 KISSEHARTYIQSLPPMPQKDLSSIFRGANPL----------AIDLLGRMLVLDSDQRVS 304 Query: 352 LKQLMVHAFIKRSDAEE 368 + + HA+ + E Sbjct: 305 AAEALAHAYFSQYHDPE 321 >2A27-A nrPDB Length = 321 Score = 241 bits (614), Expect = 5e-64, Method: Composition-based stats. Identities = 66/314 (21%), Positives = 126/314 (40%), Gaps = 51/314 (16%) Query: 65 DDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIR-----NQIIRELQVLH 119 +D ++ ELG+G +V K K +GL A K I A R +I RE+ +L Sbjct: 11 EDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILR 70 Query: 120 ECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTY 179 + ++ + + + ++ + +E + GG L L + + E+ ++ G+ Y Sbjct: 71 QVLHHNVITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNY 130 Query: 180 LREKHKIMHRDVKPSNILVNSRG----EIKLCDFGVSGQLIDS-MANSFVGTRSYMSPER 234 L K KI H D+KP NI++ + IKL DFG++ ++ D + GT +++PE Sbjct: 131 LHTK-KIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEI 189 Query: 235 LQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPG 294 + +++D+WS+G+ + G P +E Sbjct: 190 VNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITA----------------- 232 Query: 295 RPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQ 354 V+ + S +DF+ K L+K +R +++ Sbjct: 233 -----------------------VSYDFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQE 269 Query: 355 LMVHAFIKRSDAEE 368 + H +I D ++ Sbjct: 270 ALRHPWITPVDNQQ 283 >6ED6-A nrPDB Length = 415 Score = 241 bits (614), Expect = 6e-64, Method: Composition-based stats. Identities = 83/326 (25%), Positives = 139/326 (42%), Gaps = 22/326 (6%) Query: 26 AETNLEALQKKLEELELDE-----QQRKRLEAFLTQKQKVG------ELKDDDFEKISEL 74 + N+E+L L L LD ++ K ++ FL + +K+ ++K +D++ + + Sbjct: 37 SPINVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVI 96 Query: 75 GAGNGGVVFKVSHKPSGLVMARKLIHLE--IKPAIRNQIIRELQVLHECNSPYIVGFYGA 132 G G G V V HK S V A KL+ IK + E ++ NSP++V + A Sbjct: 97 GRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYA 156 Query: 133 FYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVK 192 F D + + ME+M GG L ++ +PE+ + V+ L + ++HRDVK Sbjct: 157 FQDDRYLYMVMEYMPGGDLVNLMSNYD-VPEKWAKFYTAEVVLALDAIHSM-GLIHRDVK 214 Query: 193 PSNILVNSRGEIKLCDFGVSGQLIDS---MANSFVGTRSYMSPERLQ----GTHYSVQSD 245 P N+L++ G +KL DFG ++ ++ ++ VGT Y+SPE L+ Y + D Sbjct: 215 PDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGGDGFYGRECD 274 Query: 246 IWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSR 305 WS+G+ L EM VG P + L + R Sbjct: 275 WWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDR 334 Query: 306 PPMAIFELLDYIVNEPPPKLPSGVFS 331 ++ I P K + Sbjct: 335 EVRLGRNGVEEIRQHPFFKNDQWHWD 360 >5YKS-A nrPDB Length = 377 Score = 241 bits (614), Expect = 6e-64, Method: Composition-based stats. Identities = 67/305 (21%), Positives = 126/305 (41%), Gaps = 52/305 (17%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHL-EIKPAIRNQIIRELQVLHECNSPYI 126 ++ LG G+ VV H +G +A K+I ++ + +E++ + P I Sbjct: 37 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHPNI 96 Query: 127 VGFYGAFYSDGEISICMEHMDGGSLDQVL-KKAGRIPEQILGKVSIAVIKGLTYLREKHK 185 V Y + ++ + +E DGG + + K + E + K ++ ++Y + H Sbjct: 97 VRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLH- 155 Query: 186 IMHRDVKPSN-ILVNSRGEIKLCDFGVSGQL-IDSMANSFVGTRSYMSPERLQGTHYS-V 242 ++HRD+KP N + +G +KL DFG S + + G+ +Y +PE L G Y Sbjct: 156 VVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDAP 215 Query: 243 QSDIWSMGLSLVEMAVGRYPIPP-PDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYG 301 DIWS+G+ L + G+ P D++ L ++ C+ Sbjct: 216 AVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKY---------------------- 253 Query: 302 MDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFI 361 +PS S E +D + + L ++P RA L+++ H ++ Sbjct: 254 ----------------------TVPSH-VSKECKDLITRMLQRDPKRRASLEEIENHPWL 290 Query: 362 KRSDA 366 + D Sbjct: 291 QGVDP 295 >6CQF-A nrPDB Length = 297 Score = 240 bits (613), Expect = 6e-64, Method: Composition-based stats. Identities = 82/305 (26%), Positives = 144/305 (47%), Gaps = 46/305 (15%) Query: 64 KDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNS 123 D ++ + LG G G VFK K SG ++A K++ +E + + + +E+ +L C Sbjct: 14 PRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDV-STLQKEILILKTCRH 72 Query: 124 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREK 183 IV ++G++ ++ ICME GSL + + G + E + V V++GL YL + Sbjct: 73 ANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSQ 132 Query: 184 HKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMAN--SFVGTRSYMSPE---RLQGT 238 KI HRD+K +NIL+N GE++L DFG+S Q+ ++A +F+GT +M+PE Sbjct: 133 KKI-HRDIKGANILINDAGEVRLADFGISAQIGATLARRLAFIGTPYWMAPEVAAVALKG 191 Query: 239 HYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLS 298 Y+ DIWS+G++ +E+A + P+ Sbjct: 192 GYNELCDIWSLGITAIELAELQPPLFDVH------------------------------- 220 Query: 299 SYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVH 358 P+ + L+ +PP G +S F +F+ L K+P +R +++ H Sbjct: 221 --------PLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSH 272 Query: 359 AFIKR 363 + + Sbjct: 273 QLVSQ 277 >4ZSG-A nrPDB Length = 347 Score = 240 bits (613), Expect = 7e-64, Method: Composition-based stats. Identities = 68/317 (21%), Positives = 123/317 (38%), Gaps = 29/317 (9%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIR-NQIIRELQVLHECNSP 124 D++E I +G G GVV + +G +A K I + +REL++L Sbjct: 7 DEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHD 66 Query: 125 YIVGFYGAFY------SDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLT 178 I+ + + ++ M+ L Q++ + + + + +++GL Sbjct: 67 NIIAIKDILRPTVPYGEFKSVYVVLDLMES-DLHQIIHSSQPLTLEHVRYFLYQLLRGLK 125 Query: 179 YLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL------IDSMANSFVGTRSYMSP 232 Y+ +++HRD+KPSN+LVN E+K+ DFG++ L +V TR Y +P Sbjct: 126 YMHSA-QVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAP 184 Query: 233 ERLQG-THYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPR 291 E + Y+ D+WS+G EM R P + +L V G +P + Sbjct: 185 ELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNY-VHQLQLIMMVLG--TPSPAVIQ 241 Query: 292 TPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERAD 351 G + S PP P + + + + L P+ R Sbjct: 242 AVGAERVRAYIQSLPPRQPV----------PWETVYPGADRQALSLLGRMLRFEPSARIS 291 Query: 352 LKQLMVHAFIKRSDAEE 368 + H F+ + + Sbjct: 292 AAAALRHPFLAKYHDPD 308 >3FXW-A nrPDB Length = 336 Score = 239 bits (611), Expect = 1e-63, Method: Composition-based stats. Identities = 78/338 (23%), Positives = 127/338 (37%), Gaps = 68/338 (20%) Query: 66 DDFEK-ISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSP 124 DD++ LG G G V + H+ +G A KL++ P R ++ Q P Sbjct: 28 DDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLLY--DSPKARQEVDHHWQASG---GP 82 Query: 125 YIVGFYGAFYSDGE----ISICMEHMDGGSLDQVLKKAGR--IPEQILGKVSIAVIKGLT 178 +IV + + + I ME M+GG L +++ G E+ ++ + + Sbjct: 83 HIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQ 142 Query: 179 YLREKHKIMHRDVKPSNILVNS---RGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERL 235 +L H I HRDVKP N+L S +KL DFG + + + + T Y++PE L Sbjct: 143 FLHS-HNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNALQTPCYTPYYVAPEVL 201 Query: 236 QGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGR 295 Y D+WS+G+ + + G P + + Sbjct: 202 GPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQAI------------------------ 237 Query: 296 PLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQL 355 S GM R + + P P+ S + + + L +P ER + Q Sbjct: 238 ---SPGMKRRIRLGQYGF-------PNPEWSE--VSEDAKQLIRLLLKTDPTERLTITQF 285 Query: 356 MVHAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV 393 M H +I +S + P TP H A V Sbjct: 286 MNHPWINQS----------------MVVPQTPLHTARV 307 >1ZWS-A nrPDB Length = 288 Score = 239 bits (611), Expect = 1e-63, Method: Composition-based stats. Identities = 66/314 (21%), Positives = 128/314 (40%), Gaps = 51/314 (16%) Query: 65 DDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIR-----NQIIRELQVLH 119 +D ++ ELG+G +V K K +GL A K I A R +I RE+ +L Sbjct: 11 EDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILR 70 Query: 120 ECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTY 179 + ++ + + + ++ + +E + GG L L + + E+ ++ G+ Y Sbjct: 71 QVLHHNVITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNY 130 Query: 180 LREKHKIMHRDVKPSNILVNSRG----EIKLCDFGVSGQLIDS-MANSFVGTRSYMSPER 234 L K KI H D+KP NI++ + IKL DFG++ ++ D + GT +++PE Sbjct: 131 LHTK-KIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEI 189 Query: 235 LQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPG 294 + +++D+WS+G+ + G P +E Sbjct: 190 VNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQE------------------------ 225 Query: 295 RPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQ 354 + + + + S S +DF+ K L+K +R +++ Sbjct: 226 ---------------TLANITSVSYDFDEEFFSHT-SELAKDFIRKLLVKETRKRLTIQE 269 Query: 355 LMVHAFIKRSDAEE 368 + H +I D ++ Sbjct: 270 ALRHPWITPVDNQQ 283 >6DTL-A nrPDB Length = 364 Score = 239 bits (611), Expect = 1e-63, Method: Composition-based stats. Identities = 66/303 (21%), Positives = 123/303 (40%), Gaps = 24/303 (7%) Query: 71 ISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIR-NQIIRELQVLHECNSPYIVGF 129 I +G G G+V + + +A K I I + +RE+++L + IV Sbjct: 35 IMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAI 94 Query: 130 YGAFYSD-----GEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKH 184 ++ I E MD L Q+++ + E+ +++GL Y+ + Sbjct: 95 RDIIPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSAN 153 Query: 185 KIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID-SMANSFVGTRSYMSPERLQG-THYSV 242 ++HRD+KPSN+L+N+ ++K+CDFG++ + +V TR Y +PE L + Y+ Sbjct: 154 -VLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTA 212 Query: 243 QSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGM 302 D+WS+G +E+ + P D +L ++ G +E + + Sbjct: 213 AIDVWSVGCIFMELMDRKPLFPGRDH-VHQLRLLMELIGTPSE---EELEFLNENAKRYI 268 Query: 303 DSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIK 362 PP + D P D + K L +P R + + H ++ Sbjct: 269 RQLPPYPRQSITDKFPTVHPL----------AIDLIEKMLTFDPRRRITVLDALAHPYLN 318 Query: 363 RSD 365 Sbjct: 319 SLH 321 >4CSV-A nrPDB Length = 275 Score = 239 bits (610), Expect = 2e-63, Method: Composition-based stats. Identities = 61/306 (19%), Positives = 118/306 (38%), Gaps = 52/306 (16%) Query: 58 QKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQV 117 E+ + +LG+G G V++ + + +A K + + ++E Q+ Sbjct: 3 HDKWEIPRSEITLERKLGSGQFGEVYEGKWRNYNIEVAVKTLKEGTMSV--EEFLQEAQI 60 Query: 118 LHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLK--KAGRIPEQILGKVSIAVIK 175 + + P +V YG + I I E+M GSL L+ + + Q L ++ V Sbjct: 61 MKKLKHPNLVQLYGVCTKEPPIYIITEYMSHGSLLDYLRDCEGHTVNAQALLDMAAQVAS 120 Query: 176 GLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTR---SYMSP 232 G+ YL ++ +HRD+ N LV +K+ DFG++ + + + G + + +P Sbjct: 121 GMAYLESQN-FIHRDLAARNCLVGENNVVKVADFGLARLINEDEYTARAGAKFPIKWTAP 179 Query: 233 ERLQGTHYSVQSDIWSMGLSLVEMAV-GRYPIPPPDAKELELMFGCQVEGDAAETPPRPR 291 E + +S++SD+W+ G+ L E+ G+ P P E + + PRP+ Sbjct: 180 EAISYNRFSIKSDVWAFGILLWEIFTYGQVPYPGMSGSE------VIEQVERGYRMPRPQ 233 Query: 292 TPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERAD 351 E + + +C K+P ER Sbjct: 234 GCP-------------------------------------EEIYELMLQCWNKSPEERPT 256 Query: 352 LKQLMV 357 + + Sbjct: 257 FAETLH 262 >4JG6-A nrPDB Length = 355 Score = 237 bits (605), Expect = 5e-63, Method: Composition-based stats. Identities = 71/307 (23%), Positives = 118/307 (38%), Gaps = 50/307 (16%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVL-HECNSP 124 D +E ++G G+ V + HK + + A K+I + E+++L P Sbjct: 35 DGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTE-----EIEILLRYGQHP 89 Query: 125 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKH 184 I+ + + + E M GG L + + E+ V + K + YL + Sbjct: 90 NIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQ- 148 Query: 185 KIMHRDVKPSNIL-VNSRGE---IKLCDFGVSGQL--IDSMANSFVGTRSYMSPERLQGT 238 ++HRD+KPSNIL V+ G I++CDFG + QL + + + T ++++PE L+ Sbjct: 149 GVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLERQ 208 Query: 239 HYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLS 298 Y DIWS+G+ L M G P E + G Sbjct: 209 GYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGK---------------- 252 Query: 299 SYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVH 358 F L N S +D V+K L +P +R ++ H Sbjct: 253 ------------FSLSGGYWNS---------VSDTAKDLVSKMLHVDPHQRLTAALVLRH 291 Query: 359 AFIKRSD 365 +I D Sbjct: 292 PWIVHWD 298 >3TXO-A nrPDB Length = 353 Score = 237 bits (604), Expect = 7e-63, Method: Composition-based stats. Identities = 73/309 (23%), Positives = 120/309 (38%), Gaps = 44/309 (14%) Query: 62 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEI--KPAIRNQIIRELQVLH 119 L D+FE I LG G+ G V K +G + A K++ ++ + + E ++L Sbjct: 19 RLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILS 78 Query: 120 EC-NSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLT 178 N P++ + F + + ME ++GG L ++K+ R E + +I L Sbjct: 79 LARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALM 138 Query: 179 YLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLI--DSMANSFVGTRSYMSPERLQ 236 +L +K I++RD+K N+L++ G KL DFG+ + I +F GT Y++PE LQ Sbjct: 139 FLHDK-GIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQ 197 Query: 237 GTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRP 296 Y D W+MG+ L EM G P + +L + D P Sbjct: 198 EMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEA----ILNDEVVYPTWLHEDATG 253 Query: 297 LSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLM 356 + M P M + L + ++ Sbjct: 254 ILKSFMTKNPTMRLGSLTQGGEHA----------------------------------IL 279 Query: 357 VHAFIKRSD 365 H F K D Sbjct: 280 RHPFFKEID 288 >3HDN-A nrPDB Length = 373 Score = 236 bits (602), Expect = 1e-62, Method: Composition-based stats. Identities = 73/315 (23%), Positives = 128/315 (40%), Gaps = 54/315 (17%) Query: 64 KDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE--IKPAIRNQIIRELQVL-HE 120 K DF + +G G+ G V HK + A K++ + +K I+ E VL Sbjct: 36 KPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKN 95 Query: 121 CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL 180 P++VG + +F + ++ +++++GG L L++ E + + L YL Sbjct: 96 VKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYL 155 Query: 181 REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQ--LIDSMANSFVGTRSYMSPERLQGT 238 + I++RD+KP NIL++S+G I L DFG+ + +S ++F GT Y++PE L Sbjct: 156 HSLN-IVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQ 214 Query: 239 HYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLS 298 Y D W +G L EM G P + E+ Sbjct: 215 PYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMY-------------------------- 248 Query: 299 SYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLK----Q 354 D I+N+P P+ S + + L K+ +R K + Sbjct: 249 ----------------DNILNKPLQLKPNITNS--ARHLLEGLLQKDRTKRLGAKDDFME 290 Query: 355 LMVHAFIKRSDAEEV 369 + H F + +++ Sbjct: 291 IKSHVFFSLINWDDL 305 >2WQN-A nrPDB Length = 310 Score = 236 bits (601), Expect = 1e-62, Method: Composition-based stats. Identities = 77/295 (26%), Positives = 133/295 (45%), Gaps = 49/295 (16%) Query: 67 DFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE--IKPAIRNQIIRELQVLHECNSP 124 +F ++G G V++ + G+ +A K + + + R I+E+ +L + N P Sbjct: 33 NFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHP 92 Query: 125 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR----IPEQILGKVSIAVIKGLTYL 180 ++ +Y +F D E++I +E D G L +++K + IPE+ + K + + L ++ Sbjct: 93 NVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHM 152 Query: 181 REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA--NSFVGTRSYMSPERLQGT 238 + ++MHRD+KP+N+ + + G +KL D G+ +S VGT YMSPER+ Sbjct: 153 HSR-RVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHEN 211 Query: 239 HYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLS 298 Y+ +SDIWS+G L EMA + P Sbjct: 212 GYNFKSDIWSLGCLLYEMAALQSPFYGDK------------------------------- 240 Query: 299 SYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLK 353 M ++ L I P LPS +S E + VN C+ +P +R D+ Sbjct: 241 ---------MNLYSLCKKIEQCDYPPLPSDHYSEELRQLVNMCINPDPEKRPDVT 286 >4MYG-A nrPDB Length = 372 Score = 236 bits (601), Expect = 2e-62, Method: Composition-based stats. Identities = 70/304 (23%), Positives = 118/304 (38%), Gaps = 27/304 (8%) Query: 74 LGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPA-IRNQIIRELQVLHECNSPYIVGFYGA 132 +G+G G V K SG +A K + + + REL +L ++G Sbjct: 51 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 110 Query: 133 FYSDGEI------SICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKI 186 F + + M M L +++ E+ + + ++KGL Y+ + Sbjct: 111 FTPASSLRNFYDFYLVMPFMQT-DLQKIM--GMEFSEEKIQYLVYQMLKGLKYIHSA-GV 166 Query: 187 MHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQG-THYSVQSD 245 +HRD+KP N+ VN E+K+ DFG++ D+ +V TR Y +PE + HY+ D Sbjct: 167 VHRDLKPGNLAVNEDCELKILDFGLARH-ADAEMTGYVVTRWYRAPEVILSWMHYNQTVD 225 Query: 246 IWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSR 305 IWS+G + EM G+ D +L +V G + + + S Sbjct: 226 IWSVGCIMAEMLTGKTLFKGKDYL-DQLTQILKVTG--VPGTEFVQKLNDKAAKSYIQSL 282 Query: 306 PPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKR-S 364 P + S + D + K L + +R Q + H F + Sbjct: 283 PQTPRKDFTQLFPRA----------SPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFR 332 Query: 365 DAEE 368 D EE Sbjct: 333 DPEE 336 >6QAU-A nrPDB Length = 280 Score = 235 bits (600), Expect = 2e-62, Method: Composition-based stats. Identities = 65/266 (24%), Positives = 116/266 (43%), Gaps = 14/266 (5%) Query: 65 DDDFEKISELGAGNGGVVFKVSHK-PSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNS 123 D ++ K +G G VVF+ H+ + +A K I+ + + + +E+++L E Sbjct: 10 DFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKILKELQH 69 Query: 124 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREK 183 IV Y + + ME+ +GG L L+ G + E + + + L K Sbjct: 70 ENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRILHSK 129 Query: 184 HKIMHRDVKPSNILVN---------SRGEIKLCDFGVSGQLIDS-MANSFVGTRSYMSPE 233 I+HRD+KP NIL++ S IK+ DFG + L + MA G+ YM+PE Sbjct: 130 -GIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAADLCGSPMYMAPE 188 Query: 234 RLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTP 293 + HY ++D+WS+G + + VG+ P ++L + + + PR +P Sbjct: 189 VIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNR--SLMPSIPRETSP 246 Query: 294 GRPLSSYGMDSRPPMAIFELLDYIVN 319 G+ R + + + Sbjct: 247 YLANLLLGLLQRNQKDRMDFEAFFSH 272 >4B6L-A nrPDB Length = 281 Score = 234 bits (598), Expect = 3e-62, Method: Composition-based stats. Identities = 66/311 (21%), Positives = 120/311 (38%), Gaps = 50/311 (16%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE--IKPAIRNQIIRELQVLHECNSPY 125 + K LG G ++ + +G A K+I KP R +I+ E+++ + + Sbjct: 11 YLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRH 70 Query: 126 IVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHK 185 IV F F I I +E SL + K + E + ++ GL YL ++ Sbjct: 71 IVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQR-G 129 Query: 186 IMHRDVKPSNILVNSRGEIKLCDFGVSGQL--IDSMANSFVGTRSYMSPERLQGTHYSVQ 243 I+HRD+K N + E+K+ DFG++ +L + + GT +Y++PE L + + Sbjct: 130 ILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPE 189 Query: 244 SDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMD 303 +D+WS+G + + G P D KE Sbjct: 190 ADVWSLGCVMYTLLCGSPPFETADLKE--------------------------------- 216 Query: 304 SRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFI-K 362 + + + P L SL + + L +P +R + Q++ H F K Sbjct: 217 ------TYRCIKQVHYTLPASL-----SLPARQLLAAILRASPRDRPSIDQILRHDFFTK 265 Query: 363 RSDAEEVDFAG 373 + + + Sbjct: 266 GYTPDRLPISS 276 >5DYK-A nrPDB Length = 853 Score = 234 bits (598), Expect = 4e-62, Method: Composition-based stats. Identities = 73/320 (22%), Positives = 127/320 (39%), Gaps = 50/320 (15%) Query: 57 KQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE--IKPAIRNQIIRE 114 K + +++ D+ E +G G G V V HKP+ + A K + I +N I E Sbjct: 530 KMQDTKVEMDELETERIIGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINLNQQNNIKLE 589 Query: 115 LQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVI 174 ++ E + P+I+ F E + GG L ++K G + + ++I Sbjct: 590 REITAENDHPFIIRLVRTFKDSKYFYFLTELVTGGELYDAIRKLGLLSKSQAQFYLGSII 649 Query: 175 KGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPER 234 + YL E++ I++RD+KP NIL++ +G +KL DFG + ++ A + VGT YM+PE Sbjct: 650 LAIEYLHERN-IVYRDLKPENILLDKQGYVKLIDFGCAKKV-QGRAYTLVGTPHYMAPEV 707 Query: 235 LQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPG 294 + G Y DIW++G+ L E G P + +LE+ Sbjct: 708 ILGKGYGCTVDIWALGICLYEFICGPLPFGNDEEDQLEIFRDILTGQLT----------- 756 Query: 295 RPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADL-- 352 P V + + + + L + P R Sbjct: 757 ------------------------------FPDYVTDTDSINLMKRLLCRLPQGRIGCSI 786 Query: 353 ---KQLMVHAFIKRSDAEEV 369 K + H F + +++ Sbjct: 787 NGFKDIKDHPFFSNFNWDKL 806 >5EFQ-A nrPDB Length = 347 Score = 234 bits (598), Expect = 4e-62, Method: Composition-based stats. Identities = 78/328 (23%), Positives = 132/328 (40%), Gaps = 35/328 (10%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEI-KPAIRNQIIRELQVLHECNSP 124 D F+ I +G G G V+K K +G ++A K + L+ K IRE+++L + Sbjct: 11 DKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQ 70 Query: 125 YIVGFYGAFYSDGE----------ISICMEHMDGGSLDQVLKKA-GRIPEQILGKVSIAV 173 I+ + + E+MD L +L+ E + + Sbjct: 71 SIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDH-DLMGLLESGLVHFNENHIKSFMRQL 129 Query: 174 IKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSF---VGTRSYM 230 ++GL Y +K+ +HRD+K SNIL+N+RG+IKL DFG++ + + V T Y Sbjct: 130 MEGLDYCHKKN-FLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYR 188 Query: 231 SPERLQG-THYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPR 289 PE L G Y+ D+WS G L E+ + PI + + +L ++ G P Sbjct: 189 PPELLLGEERYTPAIDVWSCGCILGELFT-KKPIFQANQELAQLELISRICGS----PCP 243 Query: 290 PRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAER 349 P Y +P L P D + L +P++R Sbjct: 244 AVWPDVIKLPYFNTMKPKKQYRRKLREEFVFIP---------AAALDLFDYMLALDPSKR 294 Query: 350 ADLKQLMVHAFIKRSDAEEV---DFAGW 374 +Q + F++ + ++ D W Sbjct: 295 CTAEQALQCEFLRDVEPSKMPPPDLPLW 322 >4NST-A nrPDB Length = 351 Score = 233 bits (594), Expect = 1e-61, Method: Composition-based stats. Identities = 76/316 (24%), Positives = 129/316 (40%), Gaps = 32/316 (10%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEI-KPAIRNQIIRELQVLHECNSP 124 D F+ I +G G G V+K K +G ++A K + L+ K IRE+++L + Sbjct: 13 DKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHR 72 Query: 125 YIVGFYGAFYSDGE----------ISICMEHMDGGSLDQVLKKA-GRIPEQILGKVSIAV 173 +V + + E+MD L +L+ E + + Sbjct: 73 SVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDH-DLMGLLESGLVHFSEDHIKSFMKQL 131 Query: 174 IKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSF---VGTRSYM 230 ++GL Y +K+ +HRD+K SNIL+N+ G+IKL DFG++ + + V T Y Sbjct: 132 MEGLEYCHKKN-FLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYR 190 Query: 231 SPERLQG-THYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPR 289 PE L G Y+ D+WS G L E+ + PI + + +L ++ G P Sbjct: 191 PPELLLGEERYTPAIDVWSCGCILGELFT-KKPIFQANLELAQLELISRLCGS----PCP 245 Query: 290 PRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAER 349 P Y +P L + P D ++ L +P++R Sbjct: 246 AVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIP---------SAALDLLDHMLTLDPSKR 296 Query: 350 ADLKQLMVHAFIKRSD 365 +Q + F+K + Sbjct: 297 CTAEQTLQSDFLKDVE 312 >2YCR-A nrPDB Length = 323 Score = 233 bits (593), Expect = 1e-61, Method: Composition-based stats. Identities = 68/315 (21%), Positives = 123/315 (39%), Gaps = 55/315 (17%) Query: 65 DDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEI--KPAIRNQ-----IIRELQV 117 D++ LG+G G V + + +A K+I + R + E+++ Sbjct: 9 RDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEI 68 Query: 118 LHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGL 177 L + N P I+ F + I +E M+GG L + R+ E ++ + Sbjct: 69 LKKLNHPCIIKIKNFF-DAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAV 127 Query: 178 TYLREKHKIMHRDVKPSNILVN---SRGEIKLCDFGVSGQLID-SMANSFVGTRSYMSPE 233 YL E + I+HRD+KP N+L++ IK+ DFG S L + S+ + GT +Y++PE Sbjct: 128 QYLHE-NGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPE 186 Query: 234 RLQ---GTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRP 290 L Y+ D WS+G+ L G P Sbjct: 187 VLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEH------------------------ 222 Query: 291 RTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERA 350 R +++ + + P++ + S + D V K L+ +P R Sbjct: 223 --------------RTQVSLKDQITSGKYNFIPEVWAE-VSEKALDLVKKLLVVDPKARF 267 Query: 351 DLKQLMVHAFIKRSD 365 ++ + H +++ D Sbjct: 268 TTEEALRHPWLQDED 282 >4QTB-A nrPDB Length = 380 Score = 232 bits (592), Expect = 2e-61, Method: Composition-based stats. Identities = 65/309 (21%), Positives = 125/309 (40%), Gaps = 27/309 (8%) Query: 67 DFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYI 126 + ++ +G G G+V +A K I + +RE+Q+L + Sbjct: 42 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENV 101 Query: 127 VGFYGAFYSDG-----EISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLR 181 +G + ++ I + M+ L ++LK + + +++GL Y+ Sbjct: 102 IGIRDILRASTLEAMRDVYIVQDLMET-DLYKLLKSQQ-LSNDHICYFLYQILRGLKYIH 159 Query: 182 EKHKIMHRDVKPSNILVNSRGEIKLCDFGVSG-----QLIDSMANSFVGTRSYMSPE-RL 235 + ++HRD+KPSN+L+N+ ++K+CDFG++ +V TR Y +PE L Sbjct: 160 SAN-VLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIML 218 Query: 236 QGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGR 295 Y+ DIWS+G L EM R PI P +L + G ++ + Sbjct: 219 NSKGYTKSIDIWSVGCILAEMLSNR-PIFPGKHYLDQLNHILGILGSPSQEDLNCIINMK 277 Query: 296 PLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQL 355 + + S P L D +++ L NP +R +++ Sbjct: 278 ARNY--LQSLPSKTKVAWAKLFPKSDSKAL----------DLLDRMLTFNPNKRITVEEA 325 Query: 356 MVHAFIKRS 364 + H ++++ Sbjct: 326 LAHPYLEQY 334 >4RA4-A nrPDB Length = 355 Score = 232 bits (592), Expect = 2e-61, Method: Composition-based stats. Identities = 73/330 (22%), Positives = 133/330 (40%), Gaps = 55/330 (16%) Query: 51 EAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE--IKPAIR 108 E + +K DF + LG G+ G V K + + A K++ + I+ Sbjct: 5 EDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDV 64 Query: 109 NQIIRELQVLHECNSP-YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILG 167 + E +VL + P ++ + F + + ME+++GG L +++ G+ E Sbjct: 65 ECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAV 124 Query: 168 KVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQ--LIDSMANSFVG 225 + + GL +L K I++RD+K N++++S G IK+ DFG+ + + +F G Sbjct: 125 FYAAEISIGLFFLH-KRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCG 183 Query: 226 TRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAE 285 T Y++PE + Y D W+ G+ L EM G+ P D EL Sbjct: 184 TPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQ------------ 231 Query: 286 TPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKN 345 ++++ V+ P S E + K+ Sbjct: 232 --------------------------SIMEHNVSYPKS------LSKEAVSICKGLMTKH 259 Query: 346 PAERADL-----KQLMVHAFIKRSDAEEVD 370 PA+R + + HAF +R D E+++ Sbjct: 260 PAKRLGCGPEGERDVREHAFFRRIDWEKLE 289 >5NGU-A nrPDB Length = 381 Score = 232 bits (591), Expect = 2e-61, Method: Composition-based stats. Identities = 69/309 (22%), Positives = 130/309 (42%), Gaps = 27/309 (8%) Query: 67 DFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYI 126 + +S +G G G+V + + +A K I + +RE+++L I Sbjct: 43 RYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENI 102 Query: 127 VGFYGAFYSDG-----EISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLR 181 +G + ++ I + M+ L ++LK + + +++GL Y+ Sbjct: 103 IGINDIIRAPTIEQMKDVYIVQDLMET-DLYKLLK-TQHLSNDHICYFLYQILRGLKYIH 160 Query: 182 EKHKIMHRDVKPSNILVNSRGEIKLCDFGVSG-----QLIDSMANSFVGTRSYMSPE-RL 235 + ++HRD+KPSN+L+N+ ++K+CDFG++ +V TR Y +PE L Sbjct: 161 SAN-VLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIML 219 Query: 236 QGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGR 295 Y+ DIWS+G L EM R PI P +L + G ++ + Sbjct: 220 NSKGYTKSIDIWSVGCILAEMLSNR-PIFPGKHYLDQLNHILGILGSPSQEDLNCIINLK 278 Query: 296 PLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQL 355 + L + P +L S D ++K L NP +R +++Q Sbjct: 279 ARNY-----------LLSLPHKNKVPWNRLFPNADSK-ALDLLDKMLTFNPHKRIEVEQA 326 Query: 356 MVHAFIKRS 364 + H ++++ Sbjct: 327 LAHPYLEQY 335 >4I6B-A nrPDB Length = 308 Score = 231 bits (590), Expect = 3e-61, Method: Composition-based stats. Identities = 70/301 (23%), Positives = 125/301 (41%), Gaps = 49/301 (16%) Query: 67 DFEKISELGAGNGGVVFKVSHKPSGLVMARKLI--HLEIKPAIRNQIIRELQVLHECNSP 124 + + LG G ++++ + V A K+I KP R +I +E+++ + Sbjct: 29 RYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKIDKEIELHRILHHK 88 Query: 125 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKH 184 ++V FY F I I +E+ S+ +LK + E + ++ GL YL E+ Sbjct: 89 HVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQ- 147 Query: 185 KIMHRDVKPSNILVNSRGEIKLCDFGVSGQLI--DSMANSFVGTRSYMSPERLQGTHYSV 242 +I+HRD+K N +N E+K+ DFG++ +L + + GT +Y+SPE L + Sbjct: 148 EILHRDLKLGNFFINESMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGA 207 Query: 243 QSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGM 302 +SDIW++G + M +GR P + KE Sbjct: 208 ESDIWALGCVMYTMLLGRPPFETTNLKETYR----------------------------- 238 Query: 303 DSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIK 362 + E +PS + + + + L KNP +R L ++ H F Sbjct: 239 --------------SIREARYTMPSSLLAP-AKHLIASMLSKNPEDRPSLDDIIRHDFFT 283 Query: 363 R 363 + Sbjct: 284 Q 284 >1VZO-A nrPDB Length = 355 Score = 231 bits (590), Expect = 3e-61, Method: Composition-based stats. Identities = 74/338 (21%), Positives = 136/338 (40%), Gaps = 61/338 (18%) Query: 49 RLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHK---PSGLVMARKLIHLEI-- 103 R +KVG ++FE + LG G G VF V +G + A K++ Sbjct: 40 RTANLTGHAEKVG---IENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIV 96 Query: 104 -KPAIRNQIIRELQVLHEC-NSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRI 161 K E QVL SP++V + AF ++ ++ + +++++GG L L + R Sbjct: 97 QKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERF 156 Query: 162 PEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA- 220 E + ++ L +L K I++RD+K NIL++S G + L DFG+S + + Sbjct: 157 TEHEVQIYVGEIVLALEHLH-KLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETE 215 Query: 221 --NSFVGTRSYMSPERLQG--THYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFG 276 F GT YM+P+ ++G + + D WS+G+ + E+ G P K + Sbjct: 216 RAYDFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEIS 275 Query: 277 CQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQD 336 ++ P S +D Sbjct: 276 RRILKSEPPYPQEM----------------------------------------SALAKD 295 Query: 337 FVNKCLIKNPAERA-----DLKQLMVHAFIKRSDAEEV 369 + + L+K+P +R D ++ H F ++ + +++ Sbjct: 296 LIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDL 333 >4U41-A nrPDB Length = 332 Score = 231 bits (590), Expect = 3e-61, Method: Composition-based stats. Identities = 93/329 (28%), Positives = 148/329 (44%), Gaps = 62/329 (18%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHEC-NSPYI 126 FE + +G G G V+K H +G + A K++ ++ +I E+ +L + + I Sbjct: 26 FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVM--DVTEDEEEEIKLEINMLKKYSHHRNI 83 Query: 127 VGFYGAFY------SDGEISICMEHMDGGSLDQVLK--KAGRIPEQILGKVSIAVIKGLT 178 +YGAF D ++ + ME GS+ ++K K + E + +S +++GL Sbjct: 84 ATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLA 143 Query: 179 YLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS--MANSFVGTRSYMSPERLQ 236 +L H ++HRD+K N+L+ E+KL DFGVS QL + N+F+GT +M+PE + Sbjct: 144 HLH-IHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIA 202 Query: 237 -----GTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPR 291 Y +SD+WS G++ +EMA G P+ Sbjct: 203 CDENPDATYDYRSDLWSCGITAIEMAEGAPPL---------------------------- 234 Query: 292 TPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERAD 351 D P A+F I PPP+L S +S +F F+ CL+KN +R Sbjct: 235 ----------CDMHPMRALF----LIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPS 280 Query: 352 LKQLMVHAFIKRSDAEEVDFAGWLCSTIG 380 +QL+ H FI R E L I Sbjct: 281 TEQLLKHPFI-RDQPNERQVRIQLKDHID 308 >3A8W-A nrPDB Length = 345 Score = 231 bits (589), Expect = 4e-61, Method: Composition-based stats. Identities = 73/319 (22%), Positives = 136/319 (42%), Gaps = 47/319 (14%) Query: 63 LKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE--IKPAIRNQIIRELQVLHE 120 L DF+ + +G G+ V V K + + A K++ E + + E V + Sbjct: 6 LGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQ 65 Query: 121 C-NSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTY 179 N P++VG + F ++ + +E+++GG L +++ ++PE+ S + L Y Sbjct: 66 ASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNY 125 Query: 180 LREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL--IDSMANSFVGTRSYMSPERLQG 237 L E+ I++RD+K N+L++S G IKL D+G+ + ++F GT +Y++PE L+G Sbjct: 126 LHER-GIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRG 184 Query: 238 THYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPL 297 Y D W++G+ + EM GR P Sbjct: 185 EDYGFSVDWWALGVLMFEMMAGRSPFD--------------------------------- 211 Query: 298 SSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADL----- 352 G P + L ++ E ++P + S++ + L K+P ER Sbjct: 212 -IVGSSDNPDQNTEDYLFQVILEKQIRIPRSL-SVKAASVLKSFLNKDPKERLGCHPQTG 269 Query: 353 -KQLMVHAFIKRSDAEEVD 370 + H F + D + ++ Sbjct: 270 FADIQGHPFFRNVDWDMME 288 >4B8L-A nrPDB Length = 286 Score = 231 bits (589), Expect = 5e-61, Method: Composition-based stats. Identities = 77/299 (25%), Positives = 123/299 (41%), Gaps = 47/299 (15%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE--IKPAIRNQIIRELQVLHECNS 123 DDF+ LG G G V+ K + +MA K++ K + +Q+ RE+++ Sbjct: 15 DDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRREIEIQSHLRH 74 Query: 124 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREK 183 P I+ Y F+ I + +E G L + L+K GR EQ + L Y E+ Sbjct: 75 PNILRMYNYFHDRKRIYLMLEFAPRGELYKELQKHGRFDEQRSATFMEELADALHYCHER 134 Query: 184 HKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQ 243 K++HRD+KP N+L+ +GE+K+ DFG S + GT Y+ PE ++G + + Sbjct: 135 -KVIHRDIKPENLLMGYKGELKIADFGWSVHAPSLRRRTMCGTLDYLPPEMIEGKTHDEK 193 Query: 244 SDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMD 303 D+W G+ E VG P P E Sbjct: 194 VDLWCAGVLCYEFLVGMPPFDSPSHTETHRRIVN-------------------------- 227 Query: 304 SRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIK 362 + + PP L G +D ++K L +P +R LK +M H ++K Sbjct: 228 -------------VDLKFPPFLSDGS-----KDLISKLLRYHPPQRLPLKGVMEHPWVK 268 >3I6U-A nrPDB Length = 419 Score = 231 bits (589), Expect = 5e-61, Method: Composition-based stats. Identities = 67/315 (21%), Positives = 123/315 (39%), Gaps = 55/315 (17%) Query: 65 DDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEI--KPAIRNQ-----IIRELQV 117 D++ LG+G G V + + +A ++I + R + E+++ Sbjct: 134 RDEYIMSKTLGSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSAREADPALNVETEIEI 193 Query: 118 LHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGL 177 L + N P I+ F + I +E M+GG L + R+ E ++ + Sbjct: 194 LKKLNHPCIIKIKNFF-DAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAV 252 Query: 178 TYLREKHKIMHRDVKPSNILVN---SRGEIKLCDFGVSGQLID-SMANSFVGTRSYMSPE 233 YL E + I+HRD+KP N+L++ IK+ DFG S L + S+ + GT +Y++PE Sbjct: 253 QYLHE-NGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPE 311 Query: 234 RLQ---GTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRP 290 L Y+ D WS+G+ L G P Sbjct: 312 VLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEH------------------------ 347 Query: 291 RTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERA 350 R +++ + + P++ + S + D V K L+ +P R Sbjct: 348 --------------RTQVSLKDQITSGKYNFIPEVWAE-VSEKALDLVKKLLVVDPKARF 392 Query: 351 DLKQLMVHAFIKRSD 365 ++ + H +++ D Sbjct: 393 TTEEALRHPWLQDED 407 >3GC0-A nrPDB Length = 329 Score = 231 bits (588), Expect = 5e-61, Method: Composition-based stats. Identities = 68/312 (21%), Positives = 126/312 (40%), Gaps = 25/312 (8%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPA-IRNQIIRELQVLHECNSP 124 D + +I++LG G G V+K + +A K I LE + + IRE+ +L E Sbjct: 34 DRYRRITKLGEGTYGEVYKAIDTVTNETVAIKRIRLEHEEEGVPGTAIREVSLLKELQHR 93 Query: 125 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKH 184 I+ + + + + E+ + L + + K + +++ +I G+ + + Sbjct: 94 NIIELKSVIHHNHRLHLIFEYAEN-DLKKYMDKNPDVSMRVIKSFLYQLINGVNFCHSR- 151 Query: 185 KIMHRDVKPSNILV-----NSRGEIKLCDFGVSGQ--LIDSMANSFVGTRSYMSPERLQG 237 + +HRD+KP N+L+ + +K+ DFG++ + + T Y PE L G Sbjct: 152 RCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQFTHEIITLWYRPPEILLG 211 Query: 238 -THYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRP 296 HYS DIWS+ EM + + P+ P D++ +L +V G P PG Sbjct: 212 SRHYSTSVDIWSIACIWAEMLM-KTPLFPGDSEIDQLFKIFEVLGL----PDDTTWPGVT 266 Query: 297 LSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLM 356 S P L + + + + L +P +R K + Sbjct: 267 ALPDWKQSFPKFRGKTLKRVLGALLDDEGLDLLTA---------MLEMDPVKRISAKNAL 317 Query: 357 VHAFIKRSDAEE 368 H + +D + Sbjct: 318 EHPYFSHNDFDP 329 >1U5R-A nrPDB Length = 348 Score = 231 bits (588), Expect = 5e-61, Method: Composition-based stats. Identities = 82/306 (26%), Positives = 135/306 (44%), Gaps = 54/306 (17%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIR--NQIIRELQVLHECNSPY 125 F + E+G G+ G V+ + V+A K + K + II+E++ L + P Sbjct: 56 FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPN 115 Query: 126 IVGFYGAFYSDGEISICMEHMDG--GSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREK 183 + + G + + + ME+ G L +V KK + E + V+ ++GL YL Sbjct: 116 TIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKK--PLQEVEIAAVTHGALQGLAYLHS- 172 Query: 184 HKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQ---GTHY 240 H ++HRDVK NIL++ G +KL DFG + + + ANSFVGT +M+PE + Y Sbjct: 173 HNMIHRDVKAGNILLSEPGLVKLGDFGSASIM--APANSFVGTPYWMAPEVILAMDEGQY 230 Query: 241 SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY 300 + D+WS+G++ +E+A + P+ Sbjct: 231 DGKVDVWSLGITCIELAERKPPLFN----------------------------------- 255 Query: 301 GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF 360 M L +I P L SG +S F++FV+ CL K P +R + L+ H F Sbjct: 256 -------MNAMSALYHIAQNESPALQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRF 308 Query: 361 IKRSDA 366 + R Sbjct: 309 VLRERP 314 >2HW6-A nrPDB Length = 307 Score = 231 bits (588), Expect = 5e-61, Method: Composition-based stats. Identities = 77/322 (23%), Positives = 130/322 (40%), Gaps = 46/322 (14%) Query: 65 DDDFEKISEL-GAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECN- 122 +D ++ SEL G G V +G A K+I + R+++ RE++ L++C Sbjct: 11 EDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQA-GHSRSRVFREVETLYQCQG 69 Query: 123 SPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLRE 182 + I+ F D + E + GGS+ ++K E+ +V V L +L Sbjct: 70 NKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHT 129 Query: 183 KHKIMHRDVKPSNILVNSR---GEIKLCDFGV---------SGQLIDSMANSFVGTRSYM 230 K I HRD+KP NIL S +K+CDF + + + G+ YM Sbjct: 130 K-GIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYM 188 Query: 231 SPERL-----QGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAE 285 +PE + Q T Y + D+WS+G+ L M G P G D E Sbjct: 189 APEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGH--------CGADCGWDRGE 240 Query: 286 TPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKN 345 + +FE + E P K + + S E +D ++K L+++ Sbjct: 241 ----------------VCRVCQNKLFESIQEGKYEFPDKDWAHI-SSEAKDLISKLLVRD 283 Query: 346 PAERADLKQLMVHAFIKRSDAE 367 +R Q++ H +++ E Sbjct: 284 AKQRLSAAQVLQHPWVQGQAPE 305 >3F3Z-A nrPDB Length = 277 Score = 230 bits (587), Expect = 6e-61, Method: Composition-based stats. Identities = 62/300 (20%), Positives = 117/300 (39%), Gaps = 47/300 (15%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIV 127 + + +G G+ G V K + + A K I + ++ +E++++ + P I+ Sbjct: 11 YTLENTIGRGSWGEVKIAVQKGTRIRRAAKKIPKYFVEDV-DRFKQEIEIMKSLDHPNII 69 Query: 128 GFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIM 187 Y F + +I + ME GG L + + E ++ V+ + Y K + Sbjct: 70 RLYETFEDNTDIYLVMELCTGGELFERVVHKRVFRESDAARIMKDVLSAVAYCH-KLNVA 128 Query: 188 HRDVKPSNILV---NSRGEIKLCDFGVSGQL-IDSMANSFVGTRSYMSPERLQGTHYSVQ 243 HRD+KP N L + +KL DFG++ + M + VGT Y+SP+ L+G Y + Sbjct: 129 HRDLKPENFLFLTDSPDSPLKLIDFGLAARFKPGKMMRTKVGTPYYVSPQVLEGL-YGPE 187 Query: 244 SDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMD 303 D WS G+ + + G P P E+ L Sbjct: 188 CDEWSAGVMMYVLLCGYPPFSAPTDSEVML------------------------------ 217 Query: 304 SRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKR 363 ++ + P + S + + + + L K+P +R Q + H + ++ Sbjct: 218 --------KIREGTFTFPEKDWLN--VSPQAESLIRRLLTKSPKQRITSLQALEHEWFEK 267 >6CMJ-A nrPDB Length = 321 Score = 230 bits (587), Expect = 7e-61, Method: Composition-based stats. Identities = 77/348 (22%), Positives = 145/348 (41%), Gaps = 65/348 (18%) Query: 53 FLTQKQKVGELKD----DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAI- 107 F + ++D D + E+G G+ GVV ++ A K++ + Sbjct: 17 FQGHHVSITGMQDCVQLDQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQA 76 Query: 108 ---------RNQIIRELQVLHECNSPYIVGFYGAFYS--DGEISICMEHMDGGSLDQVLK 156 Q+ +E+ +L + + P +V + + + E ++ G + +V Sbjct: 77 GGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEV-P 135 Query: 157 KAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL- 215 + E +IKG+ YL + KI+HRD+KPSN+LV G IK+ DFGVS + Sbjct: 136 TLKPLSEDQARFYFQDLIKGIEYLHYQ-KIIHRDIKPSNLLVGEDGHIKIADFGVSNEFK 194 Query: 216 -IDSMANSFVGTRSYMSPERLQGTH--YSVQS-DIWSMGLSLVEMAVGRYPIPPPDAKEL 271 D++ ++ VGT ++M+PE L T +S ++ D+W+MG++L G+ P E Sbjct: 195 GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPF----MDER 250 Query: 272 ELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFS 331 + +++ A E P +P + Sbjct: 251 IMCLHSKIKSQALEFPDQPD--------------------------------------IA 272 Query: 332 LEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTI 379 + +D + + L KNP R + ++ +H ++ R AE + C+ + Sbjct: 273 EDLKDLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLV 320 >4YNZ-A nrPDB Length = 342 Score = 230 bits (587), Expect = 7e-61, Method: Composition-based stats. Identities = 67/265 (25%), Positives = 121/265 (45%), Gaps = 7/265 (2%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEI-KPAIRNQIIRELQVLHECNSPYI 126 + LG G G+V H + +A K+++ E ++ ++ RE+ +L P++ Sbjct: 12 YRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHV 71 Query: 127 VGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKI 186 + + + + + + +EH+ GG L L K GR+ + K +I L + H I Sbjct: 72 LKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHS-HSI 130 Query: 187 MHRDVKPSNILVNSRGEIKLCDFGVSG-QLIDSMANSFVGTRSYMSPERLQGTHYS-VQS 244 HRD+KP N+L++ R I++ DFG++ Q+ DS+ + G+ Y PE ++G Y ++ Sbjct: 131 CHRDLKPENLLLDERNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGRKA 190 Query: 245 DIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDS 304 D+WS G+ L + VG P + ++L V PP ++ R + Sbjct: 191 DVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVDAAR 250 Query: 305 R---PPMAIFELLDYIVNEPPPKLP 326 R + NEP P+ P Sbjct: 251 RLTLEHIQKHIWYIGGKNEPEPEQP 275 >2GCD-A nrPDB Length = 309 Score = 230 bits (587), Expect = 7e-61, Method: Composition-based stats. Identities = 82/306 (26%), Positives = 135/306 (44%), Gaps = 54/306 (17%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIR--NQIIRELQVLHECNSPY 125 F + E+G G+ G V+ + V+A K + K + II+E++ L + P Sbjct: 17 FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPN 76 Query: 126 IVGFYGAFYSDGEISICMEHMDG--GSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREK 183 + + G + + + ME+ G L +V KK + E + V+ ++GL YL Sbjct: 77 TIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKK--PLQEVEIAAVTHGALQGLAYLHS- 133 Query: 184 HKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQ---GTHY 240 H ++HRDVK NIL++ G +KL DFG + + + ANSFVGT +M+PE + Y Sbjct: 134 HNMIHRDVKAGNILLSEPGLVKLGDFGSASIM--APANSFVGTPYWMAPEVILAMDEGQY 191 Query: 241 SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY 300 + D+WS+G++ +E+A + P+ Sbjct: 192 DGKVDVWSLGITCIELAERKPPLFN----------------------------------- 216 Query: 301 GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF 360 M L +I P L SG +S F++FV+ CL K P +R + L+ H F Sbjct: 217 -------MNAMSALYHIAQNESPALQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRF 269 Query: 361 IKRSDA 366 + R Sbjct: 270 VLRERP 275 >5FET-A nrPDB Length = 847 Score = 230 bits (587), Expect = 7e-61, Method: Composition-based stats. Identities = 67/256 (26%), Positives = 113/256 (44%), Gaps = 6/256 (2%) Query: 57 KQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE--IKPAIRNQIIRE 114 K + +++ + E +G G G V V HKP+ + A K + I +N I E Sbjct: 524 KMQDTKVEMHELETERIIGRGTFGTVKLVHHKPTQIRYALKCVSKRSIISLNQQNNIKLE 583 Query: 115 LQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVI 174 ++ E + P+I+ F E + GG L ++K G + + ++I Sbjct: 584 REITAENDHPFIIRLVRTFKDSNCFYFLTELVTGGELYDAIRKLGLLSKPQAQFYLGSII 643 Query: 175 KGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPER 234 + YL E++ I++RD+KP NIL++ +G +KL DFG + ++ A + VGT YM+PE Sbjct: 644 LAIEYLHERN-IVYRDLKPENILLDKQGYVKLIDFGCAKKI-QGRAYTLVGTPHYMAPEV 701 Query: 235 LQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPG 294 + G Y DIW++G+ L E G P + +E +L + P Sbjct: 702 ILGKGYGCTVDIWALGVCLYEFICGPLPF--GNDQEDQLEIFRDILTGQLTFPDYVSDQD 759 Query: 295 RPLSSYGMDSRPPMAI 310 + R P Sbjct: 760 SINLMKRLLCRLPQGR 775 >3PFQ-A nrPDB Length = 674 Score = 230 bits (586), Expect = 8e-61, Method: Composition-based stats. Identities = 69/294 (23%), Positives = 125/294 (42%), Gaps = 17/294 (5%) Query: 24 SSAETNLEALQKKLEELEL---DEQQRKRLEAFLTQKQKVG---ELKDDDFEKISELGAG 77 +E N E L++K E ++ + ++ +++ G +K DF + LG G Sbjct: 294 EGSEGNEE-LRQKFERAKIGQGTKAPEEKTANTISKFDNNGNRDRMKLTDFNFLMVLGKG 352 Query: 78 NGGVVFKVSHKPSGLVMARKLIHLE--IKPAIRNQIIRELQVLHEC-NSPYIVGFYGAFY 134 + G V K + + A K++ + I+ + E +VL P++ + F Sbjct: 353 SFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQ 412 Query: 135 SDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPS 194 + + ME+++GG L +++ GR E + + GL +L+ K I++RD+K Sbjct: 413 TMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSK-GIIYRDLKLD 471 Query: 195 NILVNSRGEIKLCDFGVSGQ--LIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLS 252 N++++S G IK+ DFG+ + +F GT Y++PE + Y D W+ G+ Sbjct: 472 NVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVL 531 Query: 253 LVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRP 306 L EM G+ P D EL + P + M P Sbjct: 532 LYEMLAGQAPFEGEDEDELFQ----SIMEHNVAYPKSMSKEAVAICKGLMTKHP 581 >5Y86-A nrPDB Length = 588 Score = 230 bits (586), Expect = 9e-61, Method: Composition-based stats. Identities = 72/331 (21%), Positives = 127/331 (38%), Gaps = 36/331 (10%) Query: 67 DFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSP-- 124 +E + +G G+ G V +V +A K++ E + Q E+++L Sbjct: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKR--FHRQAAEEIRILEHLKKQDK 265 Query: 125 ----YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR--IPEQILGKVSIAVIKGLT 178 ++ +F + + E + L +++KK Q++ K + ++++ L Sbjct: 266 TGSMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQGFSVQLVRKFAQSILQSLD 324 Query: 179 YLREKHKIMHRDVKPSNILVNSRGE--IKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQ 236 L K+KI+H D+KP NIL+ G K+ DFG S +++ +R Y +PE + Sbjct: 325 ALH-KNKIIHCDLKPENILLKHHGRSSTKVIDFG-SSCFEYQKLYTYIQSRFYRAPEIIL 382 Query: 237 GTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRP 296 G+ YS DIWS G L E+ G+ P D + C +E P R Sbjct: 383 GSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGD---QLACMMELLGMPPPKLLEQSKRA 439 Query: 297 LSSYGMDSRPPMAIFELL------------DYIVNEPPPKLPSGVFSLE------FQDFV 338 P PP +L+ F +F+ Sbjct: 440 KYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFL 499 Query: 339 NKCLIKNPAERADLKQLMVHAFIKRSDAEEV 369 +CL +P+ R Q + H +I +S + Sbjct: 500 KRCLHWDPSARLTPAQALRHPWISKSVPRPL 530 >2XYN-A nrPDB Length = 292 Score = 229 bits (584), Expect = 2e-60, Method: Composition-based stats. Identities = 65/266 (24%), Positives = 111/266 (41%), Gaps = 10/266 (3%) Query: 51 EAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQ 110 E Q E++ D +LG G G V+ K L +A K + + + Sbjct: 17 ENLYFQSMDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEV--EE 74 Query: 111 IIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR--IPEQILGK 168 ++E V+ E P +V G + I E+M G+L L++ R + +L Sbjct: 75 FLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLY 134 Query: 169 VSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTR- 227 ++ + + YL EK +HRD+ N LV +K+ DFG+S + + G + Sbjct: 135 MATQISSAMEYL-EKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKF 193 Query: 228 --SYMSPERLQGTHYSVQSDIWSMGLSLVEMAV-GRYPIPPPD-AKELELMFGCQVEGDA 283 + +PE L +S++SD+W+ G+ L E+A G P P D ++ +L+ Sbjct: 194 PIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQP 253 Query: 284 AETPPRPRTPGRPLSSYGMDSRPPMA 309 PP+ R + RP A Sbjct: 254 EGCPPKVYELMRACWKWSPADRPSFA 279 >1NY3-A nrPDB Length = 400 Score = 229 bits (584), Expect = 2e-60, Method: Composition-based stats. Identities = 76/336 (22%), Positives = 128/336 (38%), Gaps = 63/336 (18%) Query: 66 DDFEKI-SELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSP 124 DD++ LG G G V ++ +K + A K++ + P R ++ + + Sbjct: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML--QDCPKARREVELHWRASQCPHIV 118 Query: 125 YIVGFYGAFYSDGE-ISICMEHMDGGSLDQVLKKAGR--IPEQILGKVSIAVIKGLTYLR 181 IV Y Y+ + + I ME +DGG L ++ G E+ ++ ++ + + YL Sbjct: 119 RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 178 Query: 182 EKHKIMHRDVKPSNILVNS---RGEIKLCDFGVSGQLI-DSMANSFVGTRSYMSPERLQG 237 + I HRDVKP N+L S +KL DFG + + + + T Y++PE L Sbjct: 179 SIN-IAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGP 237 Query: 238 THYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPL 297 Y D+WS+G+ + + G P + Sbjct: 238 EKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAI-------------------------- 271 Query: 298 SSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMV 357 S GM +R M +E P P+ S E + + L P +R + + M Sbjct: 272 -SPGMKTRIRMGQYEF-------PNPEWSE--VSEEVKMLIRNLLKTEPTQRMTITEFMN 321 Query: 358 HAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV 393 H +I +S P TP H + V Sbjct: 322 HPWIMQST----------------KVPQTPLHTSRV 341 >2FO0-A nrPDB Length = 495 Score = 229 bits (583), Expect = 2e-60, Method: Composition-based stats. Identities = 78/379 (20%), Positives = 141/379 (37%), Gaps = 64/379 (16%) Query: 10 QLNPAPDGSAVNGTSSAETNLEAL-------QKKL-EELELDEQQRKRLEAF-LTQKQKV 60 ++N A DG + S L L L L +R + + ++ Sbjct: 152 RINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDK 211 Query: 61 GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE 120 E++ D +LG G G V++ K L +A K + + + ++E V+ E Sbjct: 212 WEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEV--EEFLKEAAVMKE 269 Query: 121 CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR--IPEQILGKVSIAVIKGLT 178 P +V G + I E M G+L L++ R + +L ++ + + Sbjct: 270 IKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAME 329 Query: 179 YLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTR---SYMSPERL 235 YL EK +HR++ N LV +K+ DFG+S + + G + + +PE L Sbjct: 330 YL-EKKNFIHRNLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESL 388 Query: 236 QGTHYSVQSDIWSMGLSLVEMAV-GRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPG 294 +S++SD+W+ G+ L E+A G P P D ++ + + E Sbjct: 389 AYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEG-------- 440 Query: 295 RPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERAD--- 351 P ++EL + C NP++R Sbjct: 441 -----------CPEKVYEL------------------------MRACWQWNPSDRPSFAE 465 Query: 352 LKQLMVHAFIKRSDAEEVD 370 + Q F + S ++EV+ Sbjct: 466 IHQAFETMFQESSISDEVE 484 >2I0E-A nrPDB Length = 353 Score = 229 bits (583), Expect = 2e-60, Method: Composition-based stats. Identities = 59/215 (27%), Positives = 102/215 (47%), Gaps = 6/215 (2%) Query: 62 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE--IKPAIRNQIIRELQVLH 119 +K DF + LG G+ G V K + + A K++ + I+ + E +VL Sbjct: 16 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 75 Query: 120 EC-NSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLT 178 P++ + F + + ME+++GG L +++ GR E + + GL Sbjct: 76 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 135 Query: 179 YLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQ--LIDSMANSFVGTRSYMSPERLQ 236 +L+ K I++RD+K N++++S G IK+ DFG+ + +F GT Y++PE + Sbjct: 136 FLQSK-GIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA 194 Query: 237 GTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKEL 271 Y D W+ G+ L EM G+ P D EL Sbjct: 195 YQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDEL 229 >3KA0-A nrPDB Length = 320 Score = 228 bits (582), Expect = 2e-60, Method: Composition-based stats. Identities = 76/336 (22%), Positives = 127/336 (37%), Gaps = 63/336 (18%) Query: 66 DDFEKI-SELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSP 124 DD++ LG G G V ++ +K + A K++ + P R ++ + + Sbjct: 15 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML--QDCPKARREVELHWRASQCPHIV 72 Query: 125 YIVGFYGAFYSDGE-ISICMEHMDGGSLDQVLKKAGR--IPEQILGKVSIAVIKGLTYLR 181 IV Y Y+ + + I ME +DGG L ++ G E+ ++ ++ + + YL Sbjct: 73 RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 132 Query: 182 EKHKIMHRDVKPSNILVNS---RGEIKLCDFGVSGQLI-DSMANSFVGTRSYMSPERLQG 237 + I HRDVKP N+L S +KL DFG + + + T Y++PE L Sbjct: 133 SIN-IAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTEPCYTPYYVAPEVLGP 191 Query: 238 THYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPL 297 Y D+WS+G+ + + G P + Sbjct: 192 EKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAI-------------------------- 225 Query: 298 SSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMV 357 S GM +R M +E P P+ S E + + L P +R + + M Sbjct: 226 -SPGMKTRIRMGQYEF-------PNPEWSE--VSEEVKMLIRNLLKTEPTQRMTITEFMN 275 Query: 358 HAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV 393 H +I +S P TP H + V Sbjct: 276 HPWIMQST----------------KVPQTPLHTSRV 295 >4XEY-B nrPDB Length = 408 Score = 228 bits (582), Expect = 3e-60, Method: Composition-based stats. Identities = 69/326 (21%), Positives = 125/326 (38%), Gaps = 55/326 (16%) Query: 54 LTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIR 113 ++ E++ D +LG G G V++ K L +A K + + + ++ Sbjct: 113 VSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEV--EEFLK 170 Query: 114 ELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR--IPEQILGKVSI 171 E V+ E P +V G + I E M G+L L++ R + +L ++ Sbjct: 171 EAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMAT 230 Query: 172 AVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTR---S 228 + + YL EK +HRD+ N LV +K+ DFG+S + + G + Sbjct: 231 QISSAMEYL-EKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIK 289 Query: 229 YMSPERLQGTHYSVQSDIWSMGLSLVEMAV-GRYPIPPPDAKELELMFGCQVEGDAAETP 287 + +PE L +S++SD+W+ G+ L E+A G P P D ++ + + E Sbjct: 290 WTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEG- 348 Query: 288 PRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPA 347 P ++EL+ C NP+ Sbjct: 349 ------------------CPEKVYELM------------------------RACWQWNPS 366 Query: 348 ERAD---LKQLMVHAFIKRSDAEEVD 370 +R + Q F + S ++EV+ Sbjct: 367 DRPSFAEIHQAFETMFQESSISDEVE 392 >6NPU-A nrPDB Length = 298 Score = 228 bits (582), Expect = 3e-60, Method: Composition-based stats. Identities = 67/325 (20%), Positives = 121/325 (37%), Gaps = 55/325 (16%) Query: 55 TQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRE 114 + E++ D +LG G G V++ K L +A K + + + ++E Sbjct: 15 SPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEV--EEFLKE 72 Query: 115 LQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR--IPEQILGKVSIA 172 V+ E P +V G + I E M G+L L++ R + +L ++ Sbjct: 73 AAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQ 132 Query: 173 VIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTR---SY 229 + + YL EK +HRD+ N LV +K+ DFG+S + + G + + Sbjct: 133 ISSAMEYL-EKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKW 191 Query: 230 MSPERLQGTHYSVQSDIWSMGLSLVEMAV-GRYPIPPPDAKELELMFGCQVEGDAAETPP 288 +PE L +S++SD+W+ G+ L E+A G P P D ++ + + E P Sbjct: 192 TAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCP 251 Query: 289 RPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAE 348 + + C NP++ Sbjct: 252 EKVY-------------------------------------------ELMRACWQWNPSD 268 Query: 349 RAD---LKQLMVHAFIKRSDAEEVD 370 R + Q F + S ++EV+ Sbjct: 269 RPSFAEIHQAFETMFQESSISDEVE 293 >2OZA-A nrPDB Length = 356 Score = 228 bits (582), Expect = 3e-60, Method: Composition-based stats. Identities = 76/336 (22%), Positives = 128/336 (38%), Gaps = 63/336 (18%) Query: 66 DDFEKI-SELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSP 124 DD++ LG G G V ++ +K + A K++ + P R ++ + + Sbjct: 17 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML--QDCPKARREVELHWRASQCPHIV 74 Query: 125 YIVGFYGAFYSDGE-ISICMEHMDGGSLDQVLKKAGR--IPEQILGKVSIAVIKGLTYLR 181 IV Y Y+ + + I ME +DGG L ++ G E+ ++ ++ + + YL Sbjct: 75 RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 134 Query: 182 EKHKIMHRDVKPSNILVNS---RGEIKLCDFGVSGQLI-DSMANSFVGTRSYMSPERLQG 237 + I HRDVKP N+L S +KL DFG + + + + T Y++PE L Sbjct: 135 SIN-IAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGP 193 Query: 238 THYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPL 297 Y D+WS+G+ + + G P + Sbjct: 194 EKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAI-------------------------- 227 Query: 298 SSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMV 357 S GM +R M +E P P+ S E + + L P +R + + M Sbjct: 228 -SPGMKTRIRMGQYEF-------PNPEWSE--VSEEVKMLIRNLLKTEPTQRMTITEFMN 277 Query: 358 HAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV 393 H +I +S P TP H + V Sbjct: 278 HPWIMQST----------------KVPQTPLHTSRV 297 >3NYO-A nrPDB Length = 576 Score = 228 bits (581), Expect = 3e-60, Method: Composition-based stats. Identities = 77/352 (21%), Positives = 144/352 (40%), Gaps = 60/352 (17%) Query: 29 NLEALQKKLEELELDEQ-QRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSH 87 ++ L+ + + Q K LE +Q V + + F + LG G G V Sbjct: 154 SVAPFADYLDSIYFNRFLQWKWLE-----RQPVTK---NTFRQYRVLGKGGFGEVCACQV 205 Query: 88 KPSGLVMARKLIHLEIKPAIRNQI--IRELQVLHECNSPYIVGFYGAFYSDGEISICMEH 145 + +G + A K + + + + + E Q+L + NS ++V A+ + + + + Sbjct: 206 RATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTL 265 Query: 146 MDGGSLDQVLKKAGR--IPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGE 203 M+GG L + G+ PE + + GL L + +I++RD+KP NIL++ G Sbjct: 266 MNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLH-RERIVYRDLKPENILLDDHGH 324 Query: 204 IKLCDFGVSGQLIDSMA-NSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYP 262 I++ D G++ + + VGT YM+PE ++ Y+ D W++G L EM G+ P Sbjct: 325 IRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSP 384 Query: 263 IPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPP 322 R E ++ +V E P Sbjct: 385 FQQ---------------------------------------RKKKIKREEVERLVKEVP 405 Query: 323 PKLPSGVFSLEFQDFVNKCLIKNPAERA-----DLKQLMVHAFIKRSDAEEV 369 + S FS + + ++ L K+PAER +++ H K+ + + + Sbjct: 406 EEY-SERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRL 456 >3PPZ-A nrPDB Length = 309 Score = 228 bits (580), Expect = 5e-60, Method: Composition-based stats. Identities = 77/303 (25%), Positives = 136/303 (44%), Gaps = 13/303 (4%) Query: 42 LDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHL 101 D + L ++ D ++GAG+ G V + G +A K++ Sbjct: 13 YDIPTTENLYFQGAMDGDDMDIPWCDLNIKEKIGAGSFGTVHRAEW--HGSDVAVKILME 70 Query: 102 EIKPAIR-NQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAG- 159 + A R N+ +RE+ ++ P IV F GA +SI E++ GSL ++L K+G Sbjct: 71 QDFHAERVNEFLREVAIMKRLRHPNIVLFMGAVTQPPNLSIVTEYLSRGSLYRLLHKSGA 130 Query: 160 --RIPEQILGKVSIAVIKGLTYLREKHK-IMHRDVKPSNILVNSRGEIKLCDFGVSGQLI 216 ++ E+ ++ V KG+ YL ++ I+HRD+K N+LV+ + +K+CDFG+S Sbjct: 131 REQLDERRRLSMAYDVAKGMNYLHNRNPPIVHRDLKSPNLLVDKKYTVKVCDFGLSRLKA 190 Query: 217 DSM--ANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELM 274 + + S GT +M+PE L+ + +SD++S G+ L E+A + P + ++ Sbjct: 191 STFLSSKSAAGTPEWMAPEVLRDEPSNEKSDVYSFGVILWELATLQQPWGNLNPAQVVAA 250 Query: 275 FGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEF 334 G + + PR P G + P I++ P + S V Sbjct: 251 VGFKCK---RLEIPRNLNPQVAAIIEGCWTNEPWKRPSFAT-IMDLLRPLIKSAVPPPNR 306 Query: 335 QDF 337 D Sbjct: 307 SDL 309 >4J52-A nrPDB Length = 293 Score = 227 bits (578), Expect = 8e-60, Method: Composition-based stats. Identities = 60/293 (20%), Positives = 115/293 (39%), Gaps = 49/293 (16%) Query: 74 LGAGNGGVVFKVSHKPSGLVMARKLIHLEI--KPAIRNQIIRELQVLHECNSPYIVGFYG 131 LG G F++S + V A K++ + KP R ++ E+ + ++VGF+G Sbjct: 22 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 81 Query: 132 AFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDV 191 F + + + +E SL ++ K+ + E ++ G YL +++++HRD+ Sbjct: 82 FFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLH-RNRVIHRDL 140 Query: 192 KPSNILVNSRGEIKLCDFGVSG--QLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSM 249 K N+ +N E+K+ DFG++ + GT +Y++PE L +S + D+WS+ Sbjct: 141 KLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGHSFEVDVWSI 200 Query: 250 GLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMA 309 G + + VG+ P KE L Sbjct: 201 GCIMYTLLVGKPPFETSCLKETYLRI---------------------------------- 226 Query: 310 IFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIK 362 + +P + + + K L +P R + +L+ F Sbjct: 227 ---------KKNEYSIPKHI-NPVAASLIQKMLQTDPTARPTINELLNDEFFT 269 >4GS6-A nrPDB Length = 315 Score = 227 bits (578), Expect = 9e-60, Method: Composition-based stats. Identities = 78/310 (25%), Positives = 131/310 (42%), Gaps = 61/310 (19%) Query: 61 GELKDDDFEKISE---LGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQV 117 G L D+++I +G G GVV K + +A K I + R I EL+ Sbjct: 1 GSLHMIDYKEIEVEEVVGRGAFGVVCKAKWRA--KDVAIKQIE---SESERKAFIVELRQ 55 Query: 118 LHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGK---VSIAVI 174 L N P IV YGA + + ME+ +GGSL VL A +P + Sbjct: 56 LSRVNHPNIVKLYGACL--NPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCS 113 Query: 175 KGLTYLREKHK--IMHRDVKPSNILVNSRGEI-KLCDFGVSGQLIDSMANSFVGTRSYMS 231 +G+ YL ++HRD+KP N+L+ + G + K+CDFG + + M N+ G+ ++M+ Sbjct: 114 QGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNN-KGSAAWMA 172 Query: 232 PERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPR 291 PE +G++YS + D++S G+ L E+ R P +M+ PP + Sbjct: 173 PEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVH----NGTRPPLIK 228 Query: 292 TPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERAD 351 +P+ S + +C K+P++R Sbjct: 229 NLPKPIES-------------------------------------LMTRCWSKDPSQRPS 251 Query: 352 LKQ---LMVH 358 +++ +M H Sbjct: 252 MEEIVKIMTH 261 >2OU7-A nrPDB Length = 335 Score = 226 bits (577), Expect = 1e-59, Method: Composition-based stats. Identities = 60/293 (20%), Positives = 115/293 (39%), Gaps = 49/293 (16%) Query: 74 LGAGNGGVVFKVSHKPSGLVMARKLIHLEI--KPAIRNQIIRELQVLHECNSPYIVGFYG 131 LG G F++S + V A K++ + KP R ++ E+ + ++VGF+G Sbjct: 49 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 108 Query: 132 AFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDV 191 F + + + +E SL ++ K+ + E ++ G YL +++++HRD+ Sbjct: 109 FFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLH-RNRVIHRDL 167 Query: 192 KPSNILVNSRGEIKLCDFGVSG--QLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSM 249 K N+ +N E+K+ DFG++ + GT +Y++PE L +S + D+WS+ Sbjct: 168 KLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGHSFEVDVWSI 227 Query: 250 GLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMA 309 G + + VG+ P KE L Sbjct: 228 GCIMYTLLVGKPPFETSCLKETYLRI---------------------------------- 253 Query: 310 IFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIK 362 + +P + + + K L +P R + +L+ F Sbjct: 254 ---------KKNEYSIPKHI-NPVAASLIQKMLQTDPTARPTINELLNDEFFT 296 >5LOH-A nrPDB Length = 341 Score = 226 bits (577), Expect = 1e-59, Method: Composition-based stats. Identities = 73/314 (23%), Positives = 122/314 (38%), Gaps = 54/314 (17%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE--IKPAIRNQIIRELQVLHECNS 123 ++F + + G G V+ G + A K++ I + +Q+ E L S Sbjct: 36 EEFSIVKPISRGAFGKVYLGQ--KGGKLYAVKVVKKADMINKNMTHQVQAERDALALSKS 93 Query: 124 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREK 183 P+IV Y + S + + ME++ GG + +L G E++ K V L YL + Sbjct: 94 PFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALALDYLH-R 152 Query: 184 HKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS--------MANSFVGTRSYMSPERL 235 H I+HRD+KP N+L+++ G IKL DFG+S ++ +F GT Y++PE L Sbjct: 153 HGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILTTRTFCGTPDYLAPELL 212 Query: 236 QGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGR 295 G + D W++G+ L E G P +++ Sbjct: 213 LGRAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQV------------------------ 248 Query: 296 PLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQL 355 + + + P S Q V L + +RA +K+L Sbjct: 249 -----------------FQNILKRDIPWPEGEEKLSDNAQSAVEILLTIDDTKRAGMKEL 291 Query: 356 MVHAFIKRSDAEEV 369 H D E + Sbjct: 292 KRHPLFSDVDWENL 305 >2X4F-A nrPDB Length = 373 Score = 226 bits (577), Expect = 1e-59, Method: Composition-based stats. Identities = 65/298 (21%), Positives = 124/298 (41%), Gaps = 48/298 (16%) Query: 72 SELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYG 131 LG G G V K +GL +A K+I + ++ E+ V+++ + ++ Y Sbjct: 95 EILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKD-KEEVKNEISVMNQLDHANLIQLYD 153 Query: 132 AFYSDGEISICMEHMDGGSLDQ-VLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRD 190 AF S +I + ME++DGG L ++ ++ + E + +G+ ++ + I+H D Sbjct: 154 AFESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQM-YILHLD 212 Query: 191 VKPSNILVNSRG--EIKLCDFGVSGQL-IDSMANSFVGTRSYMSPERLQGTHYSVQSDIW 247 +KP NIL +R +IK+ DFG++ + GT +++PE + S +D+W Sbjct: 213 LKPENILCVNRDAKQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYDFVSFPTDMW 272 Query: 248 SMGLSLVEMAVGRYPIPPP-DAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRP 306 S+G+ + G P DA+ L + C+ + + E Sbjct: 273 SVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEF-------------------- 312 Query: 307 PMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRS 364 S E ++F++K LIK + R + + H ++ Sbjct: 313 ---------------------QDISEEAKEFISKLLIKEKSWRISASEALKHPWLSDH 349 >6CKI-A nrPDB Length = 316 Score = 226 bits (575), Expect = 2e-59, Method: Composition-based stats. Identities = 74/337 (21%), Positives = 134/337 (39%), Gaps = 51/337 (15%) Query: 51 EAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQ 110 ++F + + V +L++D LG G V + + A K+I + IR++ Sbjct: 4 DSFSGRFEDVYQLQED------VLGEGAHARVQTCINLITSQEYAVKIIEKQPG-HIRSR 56 Query: 111 IIRELQVLHECN-SPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKV 169 + RE+++L++C ++ F + + E M GGS+ + K E V Sbjct: 57 VFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVV 116 Query: 170 SIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGE---IKLCDFGV---------SGQLID 217 V L +L K I HRD+KP NIL + +K+CDFG+ + Sbjct: 117 VQDVASALDFLHNK-GIAHRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPIST 175 Query: 218 SMANSFVGTRSYMSPERL-----QGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELE 272 + G+ YM+PE + + + Y + D+WS+G+ L + G P Sbjct: 176 PELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVG------- 228 Query: 273 LMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSL 332 G D E P + +FE + E P K + + S Sbjct: 229 -RCGSDCGWDRGEACPACQN----------------MLFESIQEGKYEFPDKDWAHI-SC 270 Query: 333 EFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEV 369 +D ++K L+++ +R Q++ H +++ E Sbjct: 271 AAKDLISKLLVRDAKQRLSAAQVLQHPWVQGCAPENT 307 >5ZTN-A nrPDB Length = 429 Score = 225 bits (574), Expect = 3e-59, Method: Composition-based stats. Identities = 73/328 (22%), Positives = 138/328 (42%), Gaps = 32/328 (9%) Query: 67 DFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSP-- 124 +E + +G G+ G V K +A K++ E + Q E+++L Sbjct: 98 RYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKR--FHRQAAEEIRILEHLRKQDK 155 Query: 125 ----YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR--IPEQILGKVSIAVIKGLT 178 ++ F I + E + +L +++KK ++ K + ++++ L Sbjct: 156 DNTMNVIHMLENFTFRNHICMTFELLSM-NLYELIKKNKFQGFSLPLVRKFAHSILQCLD 214 Query: 179 YLREKHKIMHRDVKPSNILVNSRGE--IKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQ 236 L K++I+H D+KP NIL+ +G IK+ DFG S +++ +R Y +PE + Sbjct: 215 ALH-KNRIIHCDLKPENILLKQQGRSGIKVIDFG-SSCYEHQRVYTYIQSRFYRAPEVIL 272 Query: 237 GTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRP 296 G Y + D+WS+G L E+ G YP+ P + + +L ++ G ++ + Sbjct: 273 GARYGMPIDMWSLGCILAELLTG-YPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKN 331 Query: 297 -LSSYGMDSRPPMAIFELLDYIVN---------EPPPKLPS------GVFSLEFQDFVNK 340 +SS G + ++N PP+ G F DF+ + Sbjct: 332 FVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQ 391 Query: 341 CLIKNPAERADLKQLMVHAFIKRSDAEE 368 CL +PA R Q + H +++R + Sbjct: 392 CLEWDPAVRMTPGQALRHPWLRRRLPKP 419 >4O2Z-A nrPDB Length = 377 Score = 224 bits (572), Expect = 3e-59, Method: Composition-based stats. Identities = 68/317 (21%), Positives = 129/317 (40%), Gaps = 28/317 (8%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIR-NQIIRELQVLHECNSPYI 126 + + LG G G+ +G ++ K + +++RE+ ++ + + Sbjct: 47 YTLLKILGMGAYGIACSCLDGDTGEKVSIKKCRDVFRDVEDGKRVLREIDMMRFFHHENL 106 Query: 127 VG-------FYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTY 179 + ++S ++ + MD ++ VL+ + E + +++GL Y Sbjct: 107 LNVVNILPPLKREYHSFEDVYVVTPLMD-VDMNVVLRSRQVLEESHMQYFVYQILRGLKY 165 Query: 180 LREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSG--QLIDSMANSFVGTRSYMSPERL-Q 236 L + + HRD+KP+N++ N E+K+ DFG+S + S +V TR Y PE L + Sbjct: 166 LHSAN-VAHRDLKPANLVTNISCELKIIDFGLSRSVDVPYSELTDYVITRWYRPPELLLE 224 Query: 237 GTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRP 296 T+YS DIWS+G EM R P+ P +L Q G Sbjct: 225 NTNYSTAVDIWSVGCIFAEM-YNRKPVFPGRNTMDQLRMIAQHIGKP------------- 270 Query: 297 LSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLM 356 + ++ R + L P +P + E DF++K +P++R ++ Sbjct: 271 -PASIVEHREALEKLNELPDGSLNIPKLVPGLAGNTEGIDFLSKMWTLDPSKRPTAADML 329 Query: 357 VHAFIKRSDAEEVDFAG 373 H ++ EE + Sbjct: 330 AHPYLAHLHDEEDEPTC 346 >4APC-A nrPDB Length = 350 Score = 224 bits (572), Expect = 3e-59, Method: Composition-based stats. Identities = 67/303 (22%), Positives = 130/303 (42%), Gaps = 49/303 (16%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHL-EIKPAIRNQIIRELQVLHECNSP 124 + + ++ ++G G+ G V G K I++ + R + RE+ VL P Sbjct: 24 EKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKHP 83 Query: 125 YIVGFYGAFYSDGEISICMEHMDGGSLDQVL--KKAGRIPEQILGKVSIAVIKGLTYLRE 182 IV + +F +G + I M++ +GG L + + +K E + + + L ++ + Sbjct: 84 NIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVHD 143 Query: 183 KHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS--MANSFVGTRSYMSPERLQGTHY 240 + KI+HRD+K NI + G ++L DFG++ L + +A + +GT Y+SPE + Y Sbjct: 144 R-KILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARACIGTPYYLSPEICENKPY 202 Query: 241 SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY 300 + +SDIW++G L E+ ++ K L L Sbjct: 203 NNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIIS----------------------- 239 Query: 301 GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF 360 S PP+++ +S + + V++ +NP +R + ++ F Sbjct: 240 --GSFPPVSL------------------HYSYDLRSLVSQLFKRNPRDRPSVNSILEKGF 279 Query: 361 IKR 363 I + Sbjct: 280 IAK 282 >4UY9-A nrPDB Length = 323 Score = 224 bits (572), Expect = 4e-59, Method: Composition-based stats. Identities = 80/333 (24%), Positives = 135/333 (40%), Gaps = 38/333 (11%) Query: 61 GELKDDDF---EKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAI---RNQIIRE 114 G+L + DF +G G G V++ G +A K + I + +E Sbjct: 1 GQLLEIDFAELTLEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQE 58 Query: 115 LQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVI 174 ++ P I+ G + + + ME GG L++VL RIP IL ++ + Sbjct: 59 AKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVL-SGKRIPPDILVNWAVQIA 117 Query: 175 KGLTYLREKH--KIMHRDVKPSNILVN--------SRGEIKLCDFGVSGQLIDSMANSFV 224 +G+ YL ++ I+HRD+K SNIL+ S +K+ DFG++ + + S Sbjct: 118 RGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAA 177 Query: 225 GTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAA 284 GT ++M+PE ++ + +S SD+WS G+ L E+ G P D L + +G + A Sbjct: 178 GTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDG--LAVAYGVAMNKLAL 235 Query: 285 ETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIK 344 P P T P + D P + + + F +D + CL Sbjct: 236 ---PIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFH-CLQD 291 Query: 345 NPAERADLKQLMVH---AFIKRSDAEEVDFAGW 374 N H + A+E + W Sbjct: 292 N----------WKHEIQEMFDQLRAKEKELRTW 314 >3DB8-A nrPDB Length = 317 Score = 224 bits (572), Expect = 4e-59, Method: Composition-based stats. Identities = 60/300 (20%), Positives = 119/300 (39%), Gaps = 49/300 (16%) Query: 67 DFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEI--KPAIRNQIIRELQVLHECNSP 124 + + LG G ++++ + V A K++ + KP + ++ E+ + ++P Sbjct: 43 RYMRGRFLGKGGFAKCYEITDMDTKEVFAGKVVPKSMLLKPHQKEKMSTEIAIHKSLDNP 102 Query: 125 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKH 184 ++VGF+G F D + + +E SL ++ K+ + E I+G+ YL + Sbjct: 103 HVVGFHGFFEDDDFVYVVLEICRRRSLLELHKRRKAVTEPEARYFMRQTIQGVQYLHN-N 161 Query: 185 KIMHRDVKPSNILVNSRGEIKLCDFGVSGQL--IDSMANSFVGTRSYMSPERLQGTHYSV 242 +++HRD+K N+ +N ++K+ DFG++ ++ GT +Y++PE L +S Sbjct: 162 RVIHRDLKLGNLFLNDDMDVKIGDFGLATKIEFDGERKKDLCGTPNYIAPEVLCKKGHSF 221 Query: 243 QSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGM 302 + DIWS+G L + VG+ P KE Sbjct: 222 EVDIWSLGCILYTLLVGKPPFETSCLKE-------------------------------- 249 Query: 303 DSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIK 362 YI + + + + L +P R + +L+ F Sbjct: 250 ------------TYIRIKKNEYSVPRHINPVASALIRRMLHADPTLRPSVAELLTDEFFT 297 >1KOB-A nrPDB Length = 387 Score = 224 bits (571), Expect = 5e-59, Method: Composition-based stats. Identities = 65/306 (21%), Positives = 124/306 (40%), Gaps = 48/306 (15%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPY 125 D ++ + ELG+G GVV + K +G V K I+ P + + E+ ++++ + P Sbjct: 51 DYYDILEELGSGAFGVVHRCVEKATGRVFVAKFINTPY-PLDKYTVKNEISIMNQLHHPK 109 Query: 126 IVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAG-RIPEQILGKVSIAVIKGLTYLREKH 184 ++ + AF E+ + +E + GG L + ++ E + +GL ++ E H Sbjct: 110 LINLHDAFEDKYEMVLILEFLSGGELFDRIAAEDYKMSEAEVINYMRQACEGLKHMHE-H 168 Query: 185 KIMHRDVKPSNILVNSR--GEIKLCDFGVSGQL-IDSMANSFVGTRSYMSPERLQGTHYS 241 I+H D+KP NI+ ++ +K+ DFG++ +L D + T + +PE + Sbjct: 169 SIVHLDIKPENIMCETKKASSVKIIDFGLATKLNPDEIVKVTTATAEFAAPEIVDREPVG 228 Query: 242 VQSDIWSMGLSLVEMAVGRYPIPPPDAKE-LELMFGCQVEGDAAETPPRPRTPGRPLSSY 300 +D+W++G+ + G P D E L+ + C E D Sbjct: 229 FYTDMWAIGVLGYVLLSGLSPFAGEDDLETLQNVKRCDWEFDEDAF-------------- 274 Query: 301 GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF 360 S E +DF+ L K P +R + + H + Sbjct: 275 ---------------------------SSVSPEAKDFIKNLLQKEPRKRLTVHDALEHPW 307 Query: 361 IKRSDA 366 +K + Sbjct: 308 LKGDHS 313 >3UTO-A nrPDB Length = 573 Score = 224 bits (571), Expect = 5e-59, Method: Composition-based stats. Identities = 71/310 (22%), Positives = 127/310 (40%), Gaps = 48/310 (15%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPY 125 D ++ ELG G GVV +V+ + +G A K + + + + + +E+Q + P Sbjct: 157 DHYDIHEELGTGAFGVVHRVTERATGNNFAAKFV-MTPHESDKETVRKEIQTMSVLRHPT 215 Query: 126 IVGFYGAFYSDGEISICMEHMDGGSLDQ-VLKKAGRIPEQILGKVSIAVIKGLTYLREKH 184 +V + AF D E+ + E M GG L + V + ++ E + V KGL ++ E + Sbjct: 216 LVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMRQVCKGLCHMHE-N 274 Query: 185 KIMHRDVKPSNILVNSR--GEIKLCDFGVSGQLIDSMA-NSFVGTRSYMSPERLQGTHYS 241 +H D+KP NI+ ++ E+KL DFG++ L + GT + +PE +G Sbjct: 275 NYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTTGTAEFAAPEVAEGKPVG 334 Query: 242 VQSDIWSMGLSLVEMAVGRYPIPPPDAKE-LELMFGCQVEGDAAETPPRPRTPGRPLSSY 300 +D+WS+G+ + G P + E L + C D + Sbjct: 335 YYTDMWSVGVLSYILLSGLSPFGGENDDETLRNVKSCDWNMDDSAF-------------- 380 Query: 301 GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF 360 S + +DF+ K L+ +P R + Q + H + Sbjct: 381 ---------------------------SGISEDGKDFIRKLLLADPNTRMTIHQALEHPW 413 Query: 361 IKRSDAEEVD 370 + +A D Sbjct: 414 LTPGNAPGRD 423 >3ORZ-A nrPDB Length = 316 Score = 223 bits (569), Expect = 9e-59, Method: Composition-based stats. Identities = 74/316 (23%), Positives = 122/316 (38%), Gaps = 57/316 (18%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE--IKPAIRNQIIRELQVLHECNS 123 +DF+ LG G+ V + A K++ IK + RE V+ + Sbjct: 37 EDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDH 96 Query: 124 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREK 183 P+ V Y F D ++ + + G L + ++K G E + ++ L YL K Sbjct: 97 PFFVKLYFCFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGK 156 Query: 184 HKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLI----DSMANSFVGTRSYMSPERLQGTH 239 I+HRD+KP NIL+N I++ DFG + L + ANSFVGT Y+SPE L Sbjct: 157 -GIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKS 215 Query: 240 YSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSS 299 SD+W++G + ++ G P + Sbjct: 216 ACKSSDLWALGCIIYQLVAGLPPFRAGNE------------------------------- 244 Query: 300 YGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQ----- 354 IF+ + + + P K F + +D V K L+ + +R ++ Sbjct: 245 --------YLIFQKIIKLEYDFPEK-----FFPKARDLVEKLLVLDATKRLGCEEMEGYG 291 Query: 355 -LMVHAFIKRSDAEEV 369 L H F + E + Sbjct: 292 PLKAHPFFESVTWENL 307 >3TKU-A nrPDB Length = 433 Score = 223 bits (568), Expect = 1e-58, Method: Composition-based stats. Identities = 79/330 (23%), Positives = 130/330 (39%), Gaps = 55/330 (16%) Query: 54 LTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE--IKPAIRNQI 111 TQ K +L +DFE I +G G G V V K + + A K+++ +K A Sbjct: 78 FTQLVKEMQLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACF 137 Query: 112 IRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKK-AGRIPEQILGKVS 170 E VL + +I + AF + + + M++ GG L +L K ++PE + Sbjct: 138 REERDVLVNGDCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYI 197 Query: 171 IAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS---MANSFVGTR 227 ++ + + + H + HRD+KP N+L++ G I+L DFG ++ D ++ VGT Sbjct: 198 GEMVLAIDSIHQLHYV-HRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTP 256 Query: 228 SYMSPERLQGT-----HYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGD 282 Y+SPE LQ Y + D WS+G+ + EM G P E G Sbjct: 257 DYISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETY--------GK 308 Query: 283 AAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCL 342 R + P S E +D + + L Sbjct: 309 IMNHEERFQFPSHVTD-------------------------------VSEEAKDLIQR-L 336 Query: 343 IKNPAERA---DLKQLMVHAFIKRSDAEEV 369 I + R ++ HAF + + E + Sbjct: 337 ICSRERRLGQNGIEDFKKHAFFEGLNWENI 366 >4AF3-A nrPDB Length = 292 Score = 223 bits (568), Expect = 1e-58, Method: Composition-based stats. Identities = 75/303 (24%), Positives = 126/303 (41%), Gaps = 47/303 (15%) Query: 62 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE--IKPAIRNQIIRELQVLH 119 DDFE LG G G V+ K S ++A K++ K + +Q+ RE+++ Sbjct: 19 HFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQA 78 Query: 120 ECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTY 179 + P I+ Y FY I + +E+ G L + L+K+ EQ + + L Y Sbjct: 79 HLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMY 138 Query: 180 LREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTH 239 K K++HRD+KP N+L+ +GE+K+ DFG S + GT Y+ PE ++G Sbjct: 139 CHGK-KVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRM 197 Query: 240 YSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSS 299 ++ + D+W +G+ E+ VG P E Sbjct: 198 HNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIV----------------------- 234 Query: 300 YGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHA 359 + + P +P+G L ++K L NP+ER L Q+ H Sbjct: 235 ----------------KVDLKFPASVPTGAQDL-----ISKLLRHNPSERLPLAQVSAHP 273 Query: 360 FIK 362 +++ Sbjct: 274 WVR 276 >6BDL-A nrPDB Length = 347 Score = 223 bits (567), Expect = 2e-58, Method: Composition-based stats. Identities = 73/316 (23%), Positives = 124/316 (39%), Gaps = 52/316 (16%) Query: 63 LKDDDFEKISELGAGNGGVVFKVSHK-PSGLVMARKLIHLE--IKPAIRNQIIRELQVLH 119 LK DF I LG G G V V K A K++ + + I E Q++ Sbjct: 31 LKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQ 90 Query: 120 ECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTY 179 +S +IV Y F + + ME GG L +L+ G + + V++ Y Sbjct: 91 GAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAY 150 Query: 180 LREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLI-DSMANSFVGTRSYMSPERLQGT 238 L K I++RD+KP N++++ RG KL DFG + ++ +F GT Y++PE + Sbjct: 151 LHSK-GIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNK 209 Query: 239 HYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLS 298 + + +D WS+G+ + E+ G P PD + + Sbjct: 210 GHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNII----------------------- 246 Query: 299 SYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERA-----DLK 353 L + E P K+ + + + K NP+ER +K Sbjct: 247 --------------LRGIDMIEFPKKI-----AKNAANLIKKLCRDNPSERLGNLKNGVK 287 Query: 354 QLMVHAFIKRSDAEEV 369 + H + + + E + Sbjct: 288 DIQKHKWFEGFNWEGL 303 >3N9X-A nrPDB Length = 432 Score = 222 bits (566), Expect = 2e-58, Method: Composition-based stats. Identities = 76/366 (20%), Positives = 140/366 (38%), Gaps = 49/366 (13%) Query: 51 EAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIR-N 109 E Q K + D++ +G G+ G V+ K + +A K ++ + I Sbjct: 12 ENLYFQGIKNVHVP-DNYIIKHLIGRGSYGYVYLAYDKNTEKNVAIKKVNRMFEDLIDCK 70 Query: 110 QIIRELQVLHECNSPYIVGFYGAFYSDG-----EISICMEHMDGGSLDQVLKKAGRIPEQ 164 +I+RE+ +L+ S YI+ Y D E+ I +E D L ++ K + E+ Sbjct: 71 RILREITILNRLKSDYIIRLYDLIIPDDLLKFDELYIVLEIADS-DLKKLFKTPIFLTEE 129 Query: 165 ILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS------ 218 + + ++ G ++ E I+HRD+KP+N L+N +K+CDFG++ + Sbjct: 130 HIKTILYNLLLGENFIHES-GIIHRDLKPANCLLNQDCSVKVCDFGLARTINSEKDTNIV 188 Query: 219 ------------------MANSFVGTRSYMSPE-RLQGTHYSVQSDIWSMGLSLVEMA-- 257 S V TR Y +PE L +Y+ DIWS G E+ Sbjct: 189 NDLEENEEPGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAELLNM 248 Query: 258 --------VGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMA 309 R+P+ P + + + + + D + Sbjct: 249 LQSHINDPTNRFPLFPGSSCFPLSPDRNSKKVHEKSNRDQLNIIFNIIGTPTEDDLKNIN 308 Query: 310 IFELLDYIVNEP-----PPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRS 364 E++ YI P K S + + + L NP +R + Q + H ++K Sbjct: 309 KPEVIKYIKLFPHRKPINLKQKYPSISDDGINLLESMLKFNPNKRITIDQALDHPYLKDV 368 Query: 365 DAEEVD 370 ++++ Sbjct: 369 RKKKLE 374 >1KOA-A nrPDB Length = 491 Score = 222 bits (566), Expect = 2e-58, Method: Composition-based stats. Identities = 71/310 (22%), Positives = 127/310 (40%), Gaps = 48/310 (15%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPY 125 D ++ ELG G GVV +V+ + +G A K + + + + + +E+Q + P Sbjct: 51 DHYDIHEELGTGAFGVVHRVTERATGNNFAAKFV-MTPHESDKETVRKEIQTMSVLRHPT 109 Query: 126 IVGFYGAFYSDGEISICMEHMDGGSLDQ-VLKKAGRIPEQILGKVSIAVIKGLTYLREKH 184 +V + AF D E+ + E M GG L + V + ++ E + V KGL ++ E + Sbjct: 110 LVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMRQVCKGLCHMHE-N 168 Query: 185 KIMHRDVKPSNILVNSR--GEIKLCDFGVSGQLIDSMA-NSFVGTRSYMSPERLQGTHYS 241 +H D+KP NI+ ++ E+KL DFG++ L + GT + +PE +G Sbjct: 169 NYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTTGTAEFAAPEVAEGKPVG 228 Query: 242 VQSDIWSMGLSLVEMAVGRYPIPPPDAKE-LELMFGCQVEGDAAETPPRPRTPGRPLSSY 300 +D+WS+G+ + G P + E L + C D + Sbjct: 229 YYTDMWSVGVLSYILLSGLSPFGGENDDETLRNVKSCDWNMDDSAF-------------- 274 Query: 301 GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF 360 S + +DF+ K L+ +P R + Q + H + Sbjct: 275 ---------------------------SGISEDGKDFIRKLLLADPNTRMTIHQALEHPW 307 Query: 361 IKRSDAEEVD 370 + +A D Sbjct: 308 LTPGNAPGRD 317 >2W96-B nrPDB Length = 306 Score = 221 bits (564), Expect = 3e-58, Method: Composition-based stats. Identities = 74/315 (23%), Positives = 133/315 (42%), Gaps = 31/315 (9%) Query: 63 LKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEI-KPAIRNQIIRELQVLHEC 121 + +E ++E+G G G V+K SG +A K + + + + +RE+ +L Sbjct: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGLPISTVREVALLRRL 60 Query: 122 N---SPYIVGFYGAFYSDG-----EISICMEHMDGGSLDQVLKKAGR--IPEQILGKVSI 171 P +V + ++++ EH+D L L KA +P + + + Sbjct: 61 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMR 119 Query: 172 AVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA-NSFVGTRSYM 230 ++GL +L + I+HRD+KP NILV S G +KL DFG++ MA + V T Y Sbjct: 120 QFLRGLDFLH-ANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALDPVVVTLWYR 178 Query: 231 SPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRP 290 +PE L + Y+ D+WS+G EM R P+ +++ +L + G PP Sbjct: 179 APEVLLQSTYATPVDMWSVGCIFAEM-FRRKPLFCGNSEADQLGKIFDLIGL----PPED 233 Query: 291 RTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERA 350 P G + PP + + + + L NP +R Sbjct: 234 DWPRDVSLPRG--AFPPRGPRPVQSVVPE----------MEESGAQLLLEMLTFNPHKRI 281 Query: 351 DLKQLMVHAFIKRSD 365 + + H+++ + + Sbjct: 282 SAFRALQHSYLHKDE 296 >4AW2-A nrPDB Length = 437 Score = 221 bits (563), Expect = 4e-58, Method: Composition-based stats. Identities = 86/376 (22%), Positives = 142/376 (37%), Gaps = 61/376 (16%) Query: 13 PAPDGSAVNGTSSAETNLEALQKKLEELELDEQQR-----KRLEAFLTQKQKVGELKDDD 67 PA + L L + L ++ + + F T K K L +D Sbjct: 17 PAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWAKPF-TSKVKQMRLHRED 75 Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE--IKPAIRNQIIRELQVLHECNSPY 125 FE + +G G G V V K + V A K+++ +K A E VL +S + Sbjct: 76 FEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDSKW 135 Query: 126 IVGFYGAFYSDGEISICMEHMDGGSLDQVLKK-AGRIPEQILGKVSIAVIKGLTYLREKH 184 I + AF D + + M++ GG L +L K R+PE++ ++ + + + H Sbjct: 136 ITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEEMARFYLAEMVIAIDSVHQLH 195 Query: 185 KIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS---MANSFVGTRSYMSPERLQ----- 236 + HRD+KP NIL++ G I+L DFG +L++ ++ VGT Y+SPE LQ Sbjct: 196 YV-HRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMEGG 254 Query: 237 GTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRP 296 Y + D WS+G+ + EM G P E E Sbjct: 255 KGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKE---------------- 298 Query: 297 LSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERA---DLK 353 F+ + + S +D + + LI + R ++ Sbjct: 299 -------------RFQFPTQVTD----------VSENAKDLIRR-LICSREHRLGQNGIE 334 Query: 354 QLMVHAFIKRSDAEEV 369 H F D + + Sbjct: 335 DFKKHPFFSGIDWDNI 350 >5YV8-A nrPDB Length = 298 Score = 221 bits (563), Expect = 4e-58, Method: Composition-based stats. Identities = 71/330 (21%), Positives = 134/330 (40%), Gaps = 76/330 (23%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAI------------------ 107 + + E+G G+ GVV ++ A K++ + Sbjct: 13 NQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGG 72 Query: 108 -------RNQIIRELQVLHECNSPYIVGFYGAFYS--DGEISICMEHMDGGSLDQVLKKA 158 Q+ +E+ +L + + P +V + + + E ++ G + +V Sbjct: 73 CIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEV-PTL 131 Query: 159 GRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL--I 216 + E +IKG+ YL + KI+HRD+KPSN+LV G IK+ DFGVS + Sbjct: 132 KPLSEDQARFYFQDLIKGIEYLHYQ-KIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGS 190 Query: 217 DSMANSFVGTRSYMSPERLQGTH--YSVQS-DIWSMGLSLVEMAVGRYPIPPPDAKELEL 273 D++ ++ VGT ++M+PE L T +S ++ D+W+MG++L G+ P E + Sbjct: 191 DALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPF----MDERIM 246 Query: 274 MFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLE 333 +++ A E P +P + + Sbjct: 247 CLHSKIKSQALEFPDQPD--------------------------------------IAED 268 Query: 334 FQDFVNKCLIKNPAERADLKQLMVHAFIKR 363 +D + + L KNP R + ++ +H ++ R Sbjct: 269 LKDLITRMLDKNPESRIVVPEIKLHPWVTR 298 >4TNB-A nrPDB Length = 590 Score = 221 bits (563), Expect = 4e-58, Method: Composition-based stats. Identities = 74/350 (21%), Positives = 137/350 (39%), Gaps = 61/350 (17%) Query: 37 LEELELDEQ-QRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMA 95 L+ + D Q K LE +Q V + + F + LG G G V + +G + A Sbjct: 162 LDSMFFDRFLQWKWLE-----RQPVTK---NTFRQYRVLGKGGFGEVCACQVRATGKMYA 213 Query: 96 RKLIHLEIKPAIRNQ--IIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQ 153 K + + + + + E Q+L + NS ++V A+ + + + + M+GG L Sbjct: 214 CKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKF 273 Query: 154 VLKKAGR--IPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGV 211 + G E+ + ++ GL L ++ ++RD+KP NIL++ G I++ D G+ Sbjct: 274 HIYNMGNPGFEEERALFYAAEILCGLEDLHHEN-TVYRDLKPENILLDDYGHIRISDLGL 332 Query: 212 SGQLID-SMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKE 270 + ++ + + VGT YM+PE L Y + D W +G + EM G+ P K Sbjct: 333 AVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKV 392 Query: 271 LELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVF 330 +V ++ S F Sbjct: 393 KREEVDRRVLET----------------------------------------EEVYSHKF 412 Query: 331 SLEFQDFVNKCLIKNPAERA-----DLKQLMVHAFIKRSDAEEVDFAGWL 375 S E + L K+ +R + ++ H F + + + ++ AG L Sbjct: 413 SEEAKSICKMLLTKDAKQRLGCQEEEAAEVKRHPFFRNMNFKRLE-AGML 461 >2XNP-A nrPDB Length = 279 Score = 221 bits (563), Expect = 4e-58, Method: Composition-based stats. Identities = 74/311 (23%), Positives = 132/311 (42%), Gaps = 56/311 (18%) Query: 64 KDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHL-EIKPAIRNQIIRELQVLHECN 122 + +D+E + +G G+ G K+ K G ++ K + + A + ++ E+ +L E Sbjct: 4 RAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELK 63 Query: 123 SPYIVGFYG--AFYSDGEISICMEHMDGGSLDQVL----KKAGRIPEQILGKVSIAVIKG 176 P IV +Y ++ + I ME+ +GG L V+ K+ + E+ + +V + Sbjct: 64 HPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLA 123 Query: 177 LTYLREK----HKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSM--ANSFVGTRSYM 230 L + H ++HRD+KP+N+ ++ + +KL DFG++ L A +FVGT YM Sbjct: 124 LKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYM 183 Query: 231 SPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRP 290 SPE++ Y+ +SDIWS+G L E+ P KEL G EG P R Sbjct: 184 SPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELA---GKIREGKFRRIPYR- 239 Query: 291 RTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERA 350 +S E + + + L R Sbjct: 240 ---------------------------------------YSDELNEIITRMLNLKDYHRP 260 Query: 351 DLKQLMVHAFI 361 +++++ + I Sbjct: 261 SVEEILENPLI 271 >3LM0-A nrPDB Length = 327 Score = 221 bits (562), Expect = 5e-58, Method: Composition-based stats. Identities = 70/314 (22%), Positives = 134/314 (42%), Gaps = 51/314 (16%) Query: 66 DDFEKI--SELGAGNGGVVFKVSHKPSGLVMARKLIHLEIK-PAIRNQIIRELQVLHECN 122 ++F + ELG G VV + K +G A K + + R +I+ E+ VL Sbjct: 27 NNFYILTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELAK 86 Query: 123 S-PYIVGFYGAFYSDGEISICMEHMDGGSLDQVL--KKAGRIPEQILGKVSIAVIKGLTY 179 S P ++ + + + EI + +E+ GG + + + A + E + ++ +++G+ Y Sbjct: 87 SCPRVINLHEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYY 146 Query: 180 LREKHKIMHRDVKPSNILVNS---RGEIKLCDFGVSGQLIDS-MANSFVGTRSYMSPERL 235 L ++ I+H D+KP NIL++S G+IK+ DFG+S ++ + +GT Y++PE L Sbjct: 147 LH-QNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACELREIMGTPEYLAPEIL 205 Query: 236 QGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGR 295 + +D+W++G+ + P D +E L Sbjct: 206 NYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNIS------------------- 246 Query: 296 PLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQL 355 VN + S DF+ L+KNP +R + Sbjct: 247 ---------------------QVNVDYSEETFSSVSQLATDFIQSLLVKNPEKRPTAEIC 285 Query: 356 MVHAFIKRSDAEEV 369 + H+++++ D E + Sbjct: 286 LSHSWLQQWDFENL 299 >4E7W-A nrPDB Length = 394 Score = 220 bits (561), Expect = 6e-58, Method: Composition-based stats. Identities = 79/340 (23%), Positives = 144/340 (42%), Gaps = 36/340 (10%) Query: 41 ELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIH 100 LD+ ++ L K GE ++ + +G G+ GVVF+ S V +K++ Sbjct: 17 PLDDPN--KVIKVLASDGKTGEQREIAYTNCKVIGNGSFGVVFQAKLVESDEVAIKKVLQ 74 Query: 101 LEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGE------ISICMEHMD---GGSL 151 + RELQ++ P +V FYS+G+ +++ +E++ + Sbjct: 75 DKRFKN------RELQIMRIVKHPNVVDLKAFFYSNGDKKDEVFLNLVLEYVPETVYRAS 128 Query: 152 DQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVN-SRGEIKLCDFG 210 K +P ++ +++ L Y+ I HRD+KP N+L++ G +KL DFG Sbjct: 129 RHYAKLKQTMPMLLIKLYMYQLLRSLAYIHSI-GICHRDIKPQNLLLDPPSGVLKLIDFG 187 Query: 211 VSGQLIDSMAN-SFVGTRSYMSPERLQG-THYSVQSDIWSMGLSLVEMAVGRYPIPPPDA 268 + LI N S++ +R Y +PE + G T+Y+ DIWS G + E+ G+ P+ P ++ Sbjct: 188 SAKILIAGEPNVSYICSRYYRAPELIFGATNYTTNIDIWSTGCVMAELMQGQ-PLFPGES 246 Query: 269 KELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSG 328 +L+ +V G + + P +Y P + PP Sbjct: 247 GIDQLVEIIKVLGTPSREQIKTMNP-----NYMEHKFPQIRPHPFSKVFRPRTPP----- 296 Query: 329 VFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEE 368 + D +++ L P+ R + + H F E Sbjct: 297 ----DAIDLISRLLEYTPSARLTAIEALCHPFFDELRTGE 332 >3DTC-A nrPDB Length = 271 Score = 220 bits (561), Expect = 7e-58, Method: Composition-based stats. Identities = 67/259 (25%), Positives = 114/259 (44%), Gaps = 21/259 (8%) Query: 62 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAI---RNQIIRELQVL 118 E+ + +G G G V++ G +A K + I + +E ++ Sbjct: 3 EIDFAELTLEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQEAKLF 60 Query: 119 HECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLT 178 P I+ G + + + ME GG L++VL RIP IL ++ + +G+ Sbjct: 61 AMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVL-SGKRIPPDILVNWAVQIARGMN 119 Query: 179 YLREKH--KIMHRDVKPSNILVN--------SRGEIKLCDFGVSGQLIDSMANSFVGTRS 228 YL ++ I+HRD+K SNIL+ S +K+ DFG++ + + S G + Sbjct: 120 YLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGAYA 179 Query: 229 YMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPP 288 +M+PE ++ + +S SD+WS G+ L E+ G P D L + +G + A P Sbjct: 180 WMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDG--LAVAYGVAMNKLAL---P 234 Query: 289 RPRTPGRPLSSYGMDSRPP 307 P T P + D P Sbjct: 235 IPSTCPEPFAKLMEDCWNP 253 >2BRG-A nrPDB Length = 297 Score = 220 bits (560), Expect = 9e-58, Method: Composition-based stats. Identities = 65/303 (21%), Positives = 118/303 (38%), Gaps = 47/303 (15%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPY 125 +D++ + LG G G V ++ + +A K++ ++ I +E+ + N Sbjct: 7 EDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHEN 66 Query: 126 IVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHK 185 +V FYG + +E+ GG L ++ +PE + ++ G+ YL Sbjct: 67 VVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLH-GIG 125 Query: 186 IMHRDVKPSNILVNSRGEIKLCDFGVSGQL----IDSMANSFVGTRSYMSPERLQGTHYS 241 I HRD+KP N+L++ R +K+ DFG++ + + N GT Y++PE L+ + Sbjct: 126 ITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFH 185 Query: 242 -VQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY 300 D+WS G+ L M G P P CQ D E Sbjct: 186 AEPVDVWSCGIVLTAMLAGELPWDQPSDS-------CQEYSDWKEKKTYL---------- 228 Query: 301 GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF 360 P K+ S + ++K L++NP+ R + + + Sbjct: 229 -------------------NPWKKIDSAPLA-----LLHKILVENPSARITIPDIKKDRW 264 Query: 361 IKR 363 + Sbjct: 265 YNK 267 >5O2C-A nrPDB Length = 380 Score = 220 bits (560), Expect = 1e-57, Method: Composition-based stats. Identities = 70/307 (22%), Positives = 126/307 (41%), Gaps = 49/307 (15%) Query: 73 ELGAGNGGVVFKVSHKPSGLVMA-RKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYG 131 ELG G V+K + + +A +L ++ A + + E ++L P IV FY Sbjct: 32 ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYD 91 Query: 132 AFYS----DGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREK-HKI 186 ++ S I + E M G+L LK+ + ++L ++KGL +L + I Sbjct: 92 SWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPPI 151 Query: 187 MHRDVKPSNILVNS-RGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSD 245 +HRD+K NI + G +K+ D G++ + S A S +GT +M+PE + HY D Sbjct: 152 IHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSVIGTPEFMAPEMYE-EHYDESVD 210 Query: 246 IWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSR 305 +++ G+ ++EMA YP Sbjct: 211 VYAFGMCMLEMATSEYPYSECQN------------------------------------- 233 Query: 306 PPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSD 365 ++ + + P + V E ++ + C+ +N +ER ++ L+ HAF Sbjct: 234 ----AAQIYRKVTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDT 289 Query: 366 AEEVDFA 372 V+ A Sbjct: 290 GLRVELA 296 >4AT3-A nrPDB Length = 299 Score = 220 bits (560), Expect = 1e-57, Method: Composition-based stats. Identities = 61/272 (22%), Positives = 106/272 (38%), Gaps = 28/272 (10%) Query: 60 VGELKDDDFEKISELGAGNGGVVFKVSH-----KPSGLVMARKLIHLEIKPAIRNQIIRE 114 V +K + ELG G G VF + +++A K + + R RE Sbjct: 7 VQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLK-DASDNARKDFHRE 65 Query: 115 LQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR-------------I 161 ++L +IV FYG + + E+M G L++ L+ G + Sbjct: 66 AELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTEL 125 Query: 162 PEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMAN 221 + + ++ + G+ YL +H +HRD+ N LV +K+ DFG+S + + Sbjct: 126 TQSQMLHIAQQIAAGMVYLASQH-FVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYY 184 Query: 222 SFVG----TRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAV-GRYPIPPPDAKELELMFG 276 G +M PE + ++ +SD+WS+G+ L E+ G+ P E+ Sbjct: 185 RVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEV---IE 241 Query: 277 CQVEGDAAETPPRPRTPGRPLSSYGMDSRPPM 308 C +G + P L P M Sbjct: 242 CITQGRVLQRPRTCPQEVYELMLGCWQREPHM 273 >3NIE-A nrPDB Length = 429 Score = 219 bits (559), Expect = 1e-57, Method: Composition-based stats. Identities = 72/355 (20%), Positives = 134/355 (37%), Gaps = 51/355 (14%) Query: 65 DDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIR-NQIIRELQVLHECNS 123 D++E +G G+ G V+ K + +A K ++ + I +I+RE+ +L+ S Sbjct: 27 PDNYEIKHLIGRGSYGYVYLAYDKNANKNVAIKKVNRMFEDLIDCKRILREITILNRLKS 86 Query: 124 PYIVGFYGAFYSDG-----EISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLT 178 YI+ + + E+ I +E D L ++ K + EQ + + ++ G Sbjct: 87 DYIIRLHDLIIPEDLLKFDELYIVLEIADS-DLKKLFKTPIFLTEQHVKTILYNLLLGEK 145 Query: 179 YLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS-------------------- 218 ++ E I+HRD+KP+N L+N +K+CDFG++ + Sbjct: 146 FIHES-GIIHRDLKPANCLLNQDCSVKICDFGLARTINSDKDIHIVNDLEEKEENEEPGP 204 Query: 219 -------MANSFVGTRSYMSPE-RLQGTHYSVQSDIWSMGLSLVEMA----------VGR 260 S V TR Y +PE L +Y+ DIWS G E+ R Sbjct: 205 HNKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDIWSTGCIFAELLNMMKSHINNPTNR 264 Query: 261 YPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNE 320 +P+ P + + + + + + + E++ YI Sbjct: 265 FPLFPGSSCFPLSPDHNSKKVHEKSNRDQLNIIFNVIGTPPEEDLKCITKQEVIKYIKLF 324 Query: 321 PP-----PKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVD 370 P S E D + L N +R + + + H ++K E ++ Sbjct: 325 PTRDGIDLSKKYSSISKEGIDLLESMLRFNAQKRITIDKALSHPYLKDVRKENLE 379 >5O2B-A nrPDB Length = 285 Score = 219 bits (559), Expect = 1e-57, Method: Composition-based stats. Identities = 69/305 (22%), Positives = 125/305 (40%), Gaps = 49/305 (16%) Query: 73 ELGAGNGGVVFKVSHKPSGLVMA-RKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYG 131 ELG G V+K + + +A +L ++ A + + E ++L P IV FY Sbjct: 23 ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYD 82 Query: 132 AFYS----DGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREK-HKI 186 ++ S I + E M G+L LK+ + ++L ++KGL +L + I Sbjct: 83 SWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPPI 142 Query: 187 MHRDVKPSNILVNS-RGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSD 245 +HRD+K NI + G +K+ D G++ + S A S +GT +M+PE + HY D Sbjct: 143 IHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSVIGTPEFMAPEMYE-EHYDESVD 201 Query: 246 IWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSR 305 +++ G+ ++EMA YP Sbjct: 202 VYAFGMCMLEMATSEYPYSECQN------------------------------------- 224 Query: 306 PPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSD 365 ++ + + P + V E ++ + C+ +N +ER ++ L+ HAF Sbjct: 225 ----AAQIYRKVTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDT 280 Query: 366 AEEVD 370 V+ Sbjct: 281 GLRVE 285 >4FR4-A nrPDB Length = 384 Score = 218 bits (556), Expect = 3e-57, Method: Composition-based stats. Identities = 63/284 (22%), Positives = 126/284 (44%), Gaps = 11/284 (3%) Query: 62 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRN--QIIRELQVLH 119 ++ D FE + +G G+ G V V + + A K ++ + + +ELQ++ Sbjct: 11 DVNFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQ 70 Query: 120 ECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTY 179 P++V + +F + ++ + ++ + GG L L++ E+ + ++ L Y Sbjct: 71 GLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELVMALDY 130 Query: 180 LREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLI-DSMANSFVGTRSYMSPERL--- 235 L+ + +I+HRD+KP NIL++ G + + DF ++ L ++ + GT+ YM+PE Sbjct: 131 LQNQ-RIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQITTMAGTKPYMAPEMFSSR 189 Query: 236 QGTHYSVQSDIWSMGLSLVEMAVGRYPI---PPPDAKELELMFGCQVEGDAAETPPRPRT 292 +G YS D WS+G++ E+ GR P +KE+ F V + + Sbjct: 190 KGAGYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHTFETTVVTYPSAWSQEMVS 249 Query: 293 PGRPLSSYGMDSR-PPMAIFELLDYIVNEPPPKLPSGVFSLEFQ 335 + L D R ++ + Y+ + + F Sbjct: 250 LLKKLLEPNPDQRFSQLSDVQNFPYMNDINWDAVFQKRLIPGFI 293 >5X8I-B nrPDB Length = 346 Score = 218 bits (556), Expect = 3e-57, Method: Composition-based stats. Identities = 78/329 (23%), Positives = 122/329 (37%), Gaps = 33/329 (10%) Query: 61 GELKDDDFEKISELGAGNGGVVFKV-SHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLH 119 G++ +E + LG G G V + HK G +A K++ E+QVL Sbjct: 8 GDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVK--NVDRYCEAARSEIQVLE 65 Query: 120 ECN--SPY----IVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPE--QILGKVSI 171 N P V F G I I E + G S +K+ G +P + K++ Sbjct: 66 HLNTTDPNSTFRCVQMLEWFEHHGHICIVFELL-GLSTYDFIKENGFLPFRLDHIRKMAY 124 Query: 172 AVIKGLTYLREKHKIMHRDVKPSNILVNS-------------------RGEIKLCDFGVS 212 + K + +L +K+ H D+KP NIL +IK+ DFG + Sbjct: 125 QICKSVNFLHS-NKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSA 183 Query: 213 GQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELE 272 D ++ V TR Y +PE + +S D+WS+G L+E +G P D+KE Sbjct: 184 T-YDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHL 242 Query: 273 LMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSL 332 M + + R A + L V Sbjct: 243 AMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQDVEHE 302 Query: 333 EFQDFVNKCLIKNPAERADLKQLMVHAFI 361 D + K L +PA+R L++ + H F Sbjct: 303 RLFDLIQKMLEYDPAKRITLREALKHPFF 331 >4E93-A nrPDB Length = 377 Score = 218 bits (554), Expect = 5e-57, Method: Composition-based stats. Identities = 69/276 (25%), Positives = 116/276 (42%), Gaps = 26/276 (9%) Query: 58 QKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQV 117 + L +D ++G GN G VF + ++A K + P ++ + ++E ++ Sbjct: 106 KDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARI 165 Query: 118 LHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAG-RIPEQILGKVSIAVIKG 176 L + + P IV G I I ME + GG L+ G R+ + L ++ G Sbjct: 166 LKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAG 225 Query: 177 LTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTR----SYMSP 232 + YL K +HRD+ N LV + +K+ DFG+S + D + + G R + +P Sbjct: 226 MEYLESKC-CIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAP 284 Query: 233 ERLQGTHYSVQSDIWSMGLSLVE-MAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPR 291 E L YS +SD+WS G+ L E ++G P P ++ +G P Sbjct: 285 EALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVE---KGGRLPCPEL-- 339 Query: 292 TPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPS 327 P A+F L++ P + PS Sbjct: 340 --------------CPDAVFRLMEQCWAYEPGQRPS 361 >3RP9-A nrPDB Length = 458 Score = 217 bits (553), Expect = 6e-57, Method: Composition-based stats. Identities = 77/405 (19%), Positives = 142/405 (35%), Gaps = 70/405 (17%) Query: 41 ELDEQQRKRL-----EAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMA 95 + + QQRK+ A + + ++ D +E +G G+ G V + K V+A Sbjct: 24 QQEGQQRKQHHSSKPTASMPRPHSDWQIP-DRYEIRHLIGTGSYGHVCEAYDKLEKRVVA 82 Query: 96 RKLIHLEIKPAIR-NQIIRELQVLHECNSPYIVGFYGAFYSDG-----EISICMEHMDGG 149 K I + I +I+RE+ +L+ N ++V E+ + +E D Sbjct: 83 IKKILRVFEDLIDCKRILREIAILNRLNHDHVVKVLDIVIPKDVEKFDELYVVLEIADS- 141 Query: 150 SLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDF 209 ++ + + E + + ++ G+ Y+ I+HRD+KP+N LVN +K+CDF Sbjct: 142 DFKKLFRTPVYLTELHIKTLLYNLLVGVKYVHSA-GILHRDLKPANCLVNQDCSVKVCDF 200 Query: 210 GVSGQLI-----------------------------DSMANSFVGTRSYMSPE-RLQGTH 239 G++ + V TR Y +PE L + Sbjct: 201 GLARTVDYPENGNSQLPISPREDDMNLVTFPHTKNLKRQLTGHVVTRWYRAPELILLQEN 260 Query: 240 YSVQSDIWSMGLSLVEMAV-----------------GRYPIPPPDAKELELMFGCQVEGD 282 Y+ D+WS+G E+ G P ++ F G+ Sbjct: 261 YTEAIDVWSIGCIFAELLNMIKENVAYHADRGPLFPGSSCFPLSPDQKAGNDFKFHTRGN 320 Query: 283 AAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPS-----GVFSLEFQDF 337 + G P + + + YI P + S + Sbjct: 321 RDQLNVIFNILGTPSE----EDIEALEKEDAKRYIRIFPKREGTDLAERFPASSADAIHL 376 Query: 338 VNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLN 382 + + L+ NP +R + + + H F K EV+ + N Sbjct: 377 LKRMLVFNPNKRITINECLAHPFFKEVRIAEVETNATEKVRLPFN 421 >5AIR-A nrPDB Length = 430 Score = 217 bits (553), Expect = 7e-57, Method: Composition-based stats. Identities = 78/348 (22%), Positives = 138/348 (39%), Gaps = 33/348 (9%) Query: 36 KLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMA 95 ++ +D+ K T Q ++ + +G G+ GVV++ SG ++A Sbjct: 34 GSMKVSIDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVA 93 Query: 96 RKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGE------ISICMEHMD-- 147 K + + + R ELQ++ + + IV FYS GE +++ ++++ Sbjct: 94 IKKVLQDKRFKNR-----ELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPET 148 Query: 148 -GGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEI-K 205 + +P + + + L Y+ I HRD+KP N+L++ + K Sbjct: 149 VYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHS-FGICHRDIKPQNLLLDPDTAVLK 207 Query: 206 LCDFGVSGQLIDSMAN-SFVGTRSYMSPERLQG-THYSVQSDIWSMGLSLVEMAVGRYPI 263 LCDFG + QL+ N S++ +R Y +PE + G T Y+ D+WS G L E+ +G+ PI Sbjct: 208 LCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQ-PI 266 Query: 264 PPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPP 323 P D+ +L+ +V G R P + I P Sbjct: 267 FPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKF--------------PQIKAHPWT 312 Query: 324 KLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDF 371 K+ E ++ L P R + H+F V Sbjct: 313 KVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKL 360 >4EBW-A nrPDB Length = 304 Score = 217 bits (552), Expect = 8e-57, Method: Composition-based stats. Identities = 56/267 (20%), Positives = 108/267 (40%), Gaps = 11/267 (4%) Query: 51 EAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHK---PSGLVMARKLIHLEIKPAI 107 + + + E++ + E +G G G V + + L +A K ++ Sbjct: 23 QGAMGSSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSV 82 Query: 108 RNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLK-KAGRIPEQIL 166 R + ++E + + + P+IV G ++ + I ME G L L+ + + L Sbjct: 83 REKFLQEALTMRQFDHPHIVKLIGV-ITENPVWIIMELCTLGELRSFLQVRKYSLDLASL 141 Query: 167 GKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGT 226 + + L YL K + +HRD+ N+LV+S +KL DFG+S + DS Sbjct: 142 ILYAYQLSTALAYLESK-RFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKG 200 Query: 227 R---SYMSPERLQGTHYSVQSDIWSMGLSLVEMAV-GRYPIPPPDAKELE-LMFGCQVEG 281 + +M+PE + ++ SD+W G+ + E+ + G P ++ + + Sbjct: 201 KLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLP 260 Query: 282 DAAETPPRPRTPGRPLSSYGMDSRPPM 308 PP + +Y RP Sbjct: 261 MPPNCPPTLYSLMTKCWAYDPSRRPRF 287 >4UYA-A nrPDB Length = 340 Score = 217 bits (552), Expect = 9e-57, Method: Composition-based stats. Identities = 67/271 (24%), Positives = 116/271 (42%), Gaps = 19/271 (7%) Query: 51 EAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKP---AI 107 E Q V + + E +GAG G V++ + + G +A K + + A Sbjct: 12 ENLYFQGSPV-HVAFERLELKELIGAGGFGQVYRATWQ--GQEVAVKAARQDPEQDAAAA 68 Query: 108 RNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILG 167 + RE ++ P I+ G + + +E GG+L++ L RIP +L Sbjct: 69 AESVRREARLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGALNRAL-AGRRIPPHVLV 127 Query: 168 KVSIAVIKGLTYLREKH--KIMHRDVKPSNILVNS--------RGEIKLCDFGVSGQLID 217 ++ + +G+ YL E+ I+HRD+K SNIL+ +K+ DFG++ + Sbjct: 128 NWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHR 187 Query: 218 SMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGC 277 + + G ++M+PE ++ + +S SDIWS G+ L E+ G P D L + +G Sbjct: 188 TTKMATAGAYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDG--LAVAYGV 245 Query: 278 QVEGDAAETPPRPRTPGRPLSSYGMDSRPPM 308 V P P L P + Sbjct: 246 AVNKLTLPIPSTCPEPFAKLMKECWQQDPHI 276 >5UUU-A nrPDB Length = 547 Score = 216 bits (551), Expect = 1e-56, Method: Composition-based stats. Identities = 68/319 (21%), Positives = 127/319 (39%), Gaps = 53/319 (16%) Query: 62 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQII--RELQVLH 119 L +DF +G G G V+ +G + A K + + + + + E +L Sbjct: 194 HLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 253 Query: 120 EC---NSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKG 176 + P+IV AF++ ++S ++ M+GG L L + G E + + +I G Sbjct: 254 LVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILG 313 Query: 177 LTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQ 236 L ++ + +++RD+KP+NIL++ G +++ D G++ ++ VGT YM+PE LQ Sbjct: 314 LEHMHNRF-VVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQ 372 Query: 237 -GTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGR 295 G Y +D +S+G L ++ G P K+ Sbjct: 373 KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKD------------------------- 407 Query: 296 PLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERA----- 350 + +D EL D FS E + + L ++ R Sbjct: 408 ---KHEIDRMTLTMAVELPD-------------SFSPELRSLLEGLLQRDVNRRLGCLGR 451 Query: 351 DLKQLMVHAFIKRSDAEEV 369 +++ F + D + V Sbjct: 452 GAQEVKESPFFRSLDWQMV 470 >5VO2-A nrPDB Length = 300 Score = 216 bits (551), Expect = 1e-56, Method: Composition-based stats. Identities = 70/303 (23%), Positives = 119/303 (39%), Gaps = 54/303 (17%) Query: 57 KQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQ 116 + + E+ ++ + +G+G G VF G +A K + R+ +++ Sbjct: 3 SEDLWEVPFEEILDLQWVGSGAQGAVFLGRF--HGEEVAVKKV--------RDLKETDIK 52 Query: 117 VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKG 176 L + P I+ F G I ME G L +VL+ + +L S+ + G Sbjct: 53 HLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGG 112 Query: 177 LTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMAN-SFVGTRSYMSPERL 235 + YL HKI+HRD+K N+L+ +K+ DFG S +L D SF GT ++M+PE + Sbjct: 113 MNYLH-LHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVI 171 Query: 236 QGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGR 295 + S + DIWS G+ L E+ G P D+ + G + P P + Sbjct: 172 RNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAI-----IWGVGSNSLHLPVPSSCP- 225 Query: 296 PLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQL 355 F+ + +C P R +Q+ Sbjct: 226 ------------------------------------DGFKILLRQCWNSKPRNRPSFRQI 249 Query: 356 MVH 358 ++H Sbjct: 250 LLH 252 >3KN6-A nrPDB Length = 325 Score = 216 bits (551), Expect = 1e-56, Method: Composition-based stats. Identities = 63/298 (21%), Positives = 110/298 (36%), Gaps = 44/298 (14%) Query: 72 SELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECN-SPYIVGFY 130 LG G+ + K HK S A K+I ++ + +E+ L C P IV + Sbjct: 17 KPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQ----KEITALKLCEGHPNIVKLH 72 Query: 131 GAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRD 190 F+ + ME ++GG L + +KK E + ++ ++++ + ++HRD Sbjct: 73 EVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHD-VGVVHRD 131 Query: 191 VKPSNILV---NSRGEIKLCDFGVSGQLI--DSMANSFVGTRSYMSPERLQGTHYSVQSD 245 +KP N+L N EIK+ DFG + + + T Y +PE L Y D Sbjct: 132 LKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYDESCD 191 Query: 246 IWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSR 305 +WS+G+ L M G+ P D + Sbjct: 192 LWSLGVILYTMLSGQVPFQSHD----------------------RSLTCTSAVEIMKKIK 229 Query: 306 PPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKR 363 FE + S E +D + L +P +R + L + +++ Sbjct: 230 KGDFSFEGEAW-----------KNVSQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQD 276 >3V5Q-A nrPDB Length = 297 Score = 216 bits (550), Expect = 1e-56, Method: Composition-based stats. Identities = 68/324 (20%), Positives = 116/324 (35%), Gaps = 71/324 (21%) Query: 60 VGELKDDDFEKISELGAGNGGVVFKVSH-----KPSGLVMARKLIHLEIKPAIRNQIIRE 114 V +K D ELG G G VF +++A K + + A R RE Sbjct: 9 VQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALK-DPTLAARKDFQRE 67 Query: 115 LQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR-------------- 160 ++L +IV FYG + + E+M G L++ L+ G Sbjct: 68 AELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAK 127 Query: 161 --IPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS 218 + + ++ + G+ YL +H +HRD+ N LV + +K+ DFG+S + + Sbjct: 128 GELGLSQMLHIASQIASGMVYLASQH-FVHRDLATRNCLVGANLLVKIGDFGMSRDVYST 186 Query: 219 MANSFVG----TRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAV-GRYPIPPPDAKELEL 273 G +M PE + ++ +SD+WS G+ L E+ G+ P E+ Sbjct: 187 DYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEV-- 244 Query: 274 MFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLE 333 C +G E P V E Sbjct: 245 -IECITQGRVLERPR----------------------------------------VCPKE 263 Query: 334 FQDFVNKCLIKNPAERADLKQLMV 357 D + C + P +R ++K++ Sbjct: 264 VYDVMLGCWQREPQQRLNIKEIYK 287 >6FYV-A nrPDB Length = 337 Score = 216 bits (549), Expect = 2e-56, Method: Composition-based stats. Identities = 74/329 (22%), Positives = 124/329 (37%), Gaps = 33/329 (10%) Query: 61 GELKDDDFEKISELGAGNGGVVFKV-SHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLH 119 G++ +E + LG G G V + H G+ +A K++ + R E+QVL Sbjct: 9 GDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGR--YREAARSEIQVLE 66 Query: 120 ECNS--PY----IVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQI--LGKVSI 171 NS P V F G + I E + G S +K+ +P QI + +++ Sbjct: 67 HLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELL-GLSTYDFIKENSFLPFQIDHIRQMAY 125 Query: 172 AVIKGLTYLREKHKIMHRDVKPSNILVNS-------------------RGEIKLCDFGVS 212 + + + +L +K+ H D+KP NIL +IK+ DFG + Sbjct: 126 QICQSINFLHH-NKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSA 184 Query: 213 GQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELE 272 D ++ V TR Y +PE + +S D+WS+G L+E +G D+KE Sbjct: 185 T-YDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHL 243 Query: 273 LMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSL 332 M + + R + A + L Sbjct: 244 AMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHE 303 Query: 333 EFQDFVNKCLIKNPAERADLKQLMVHAFI 361 + D V + L +P +R L + + H F Sbjct: 304 KLFDLVRRMLEYDPTQRITLDEALQHPFF 332 >4XI2-A nrPDB Length = 446 Score = 215 bits (548), Expect = 2e-56, Method: Composition-based stats. Identities = 71/273 (26%), Positives = 114/273 (41%), Gaps = 10/273 (3%) Query: 45 QQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIK 104 +Q K + E+ D + ELG G GVV + +A K+I Sbjct: 166 KQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRG-QYDVAIKMIRE--G 222 Query: 105 PAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKK-AGRIPE 163 ++ I E +V+ + +V YG I I E+M G L L++ R Sbjct: 223 SMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQT 282 Query: 164 QILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSF 223 Q L ++ V + + YL K + +HRD+ N LVN +G +K+ DFG+S ++D S Sbjct: 283 QQLLEMCKDVCEAMEYLESK-QFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSS 341 Query: 224 VGTR---SYMSPERLQGTHYSVQSDIWSMGLSLVEM-AVGRYPIPPPDAKEL-ELMFGCQ 278 VG++ + PE L + +S +SDIW+ G+ + E+ ++G+ P E E + Sbjct: 342 VGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGL 401 Query: 279 VEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIF 311 R T D RP I Sbjct: 402 RLYRPHLASERVYTIMYSCWHEKADERPSFKIL 434 >3PVW-A nrPDB Length = 695 Score = 215 bits (548), Expect = 3e-56, Method: Composition-based stats. Identities = 68/319 (21%), Positives = 127/319 (39%), Gaps = 53/319 (16%) Query: 62 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQII--RELQVLH 119 L +DF +G G G V+ +G + A K + + + + + E +L Sbjct: 185 HLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 244 Query: 120 EC---NSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKG 176 + P+IV AF++ ++S ++ M+GG L L + G E + + +I G Sbjct: 245 LVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILG 304 Query: 177 LTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQ 236 L ++ + +++RD+KP+NIL++ G +++ D G++ ++ VGT YM+PE LQ Sbjct: 305 LEHMHNRF-VVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQ 363 Query: 237 -GTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGR 295 G Y +D +S+G L ++ G P K+ Sbjct: 364 KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKD------------------------- 398 Query: 296 PLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERA----- 350 + +D EL D FS E + + L ++ R Sbjct: 399 ---KHEIDRMTLTMAVELPD-------------SFSPELRSLLEGLLQRDVNRRLGCLGR 442 Query: 351 DLKQLMVHAFIKRSDAEEV 369 +++ F + D + V Sbjct: 443 GAQEVKESPFFRSLDWQMV 461 >2J0K-A nrPDB Length = 656 Score = 214 bits (546), Expect = 4e-56, Method: Composition-based stats. Identities = 59/312 (18%), Positives = 120/312 (38%), Gaps = 16/312 (5%) Query: 11 LNPAPDGSAVNGTSSAETNLEALQKKLEELELDE-----QQRKRLEAFLTQKQKVGELKD 65 + P +G + N E + + + E + + + + E++ Sbjct: 330 IRPQKEGERALPSIPKLANNEKQGVRSHTVSVSETDDYAEIIDEEDTYTMPSTRDYEIQR 389 Query: 66 DDFEKISELGAGNGGVVFKVSHK---PSGLVMARKLIHLEIKPAIRNQIIRELQVLHECN 122 + E +G G G V + + + +A K ++R + ++E + + + Sbjct: 390 ERIELGRCIGEGQFGDVHQGIYMSPENPAMAVAIKTCKNCTSDSVREKFLQEALTMRQFD 449 Query: 123 SPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLK-KAGRIPEQILGKVSIAVIKGLTYLR 181 P+IV G ++ + I ME G L L+ + + L + + L YL Sbjct: 450 HPHIVKLIGV-ITENPVWIIMELCTLGELRSFLQVRKFSLDLASLILYAYQLSTALAYLE 508 Query: 182 EKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTR---SYMSPERLQGT 238 K + +HRD+ N+LV++ +KL DFG+S + DS + +M+PE + Sbjct: 509 SK-RFVHRDIAARNVLVSATDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFR 567 Query: 239 HYSVQSDIWSMGLSLVEMAV-GRYPIPPPDAKELE-LMFGCQVEGDAAETPPRPRTPGRP 296 ++ SD+W G+ + E+ + G P ++ + + PP + Sbjct: 568 RFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTK 627 Query: 297 LSSYGMDSRPPM 308 +Y RP Sbjct: 628 CWAYDPSRRPRF 639 >4PWN-A nrPDB Length = 274 Score = 214 bits (546), Expect = 4e-56, Method: Composition-based stats. Identities = 72/313 (23%), Positives = 127/313 (40%), Gaps = 51/313 (16%) Query: 60 VGELKDDDFEKIS-ELGAGNGGVVFKVSHKPSGLVMA-RKLIHLEIKPAIRNQIIRELQV 117 VG D F K E+G G+ V+K + + +A +L ++ + R + E ++ Sbjct: 3 VGMSNDGRFLKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEM 62 Query: 118 LHECNSPYIVGFYGAFYS----DGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAV 173 L P IV FY ++ S I + E M G+L LK+ + ++L + Sbjct: 63 LKGLQHPNIVRFYDSWESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQI 122 Query: 174 IKGLTYLREK-HKIMHRDVKPSNILVNS-RGEIKLCDFGVSG-QLIDSMANSFVGTRSYM 230 +KGL +L + I+HRD+K NI + G +K+ D G++ + S A S +GT +M Sbjct: 123 LKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLEKRASFAKSVIGTPEFM 182 Query: 231 SPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRP 290 +PE + Y D+++ G+ ++EMA YP Sbjct: 183 APEMYE-EKYDESVDVYAFGMCMLEMATSEYPYSECQN---------------------- 219 Query: 291 RTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERA 350 ++ + + P V E ++ + C+ +N ER Sbjct: 220 -------------------AAQIYRRVTSGVKPASFDKVAIPEVKEIIEGCIRQNKDERY 260 Query: 351 DLKQLMVHAFIKR 363 +K L+ HAF + Sbjct: 261 SIKDLLNHAFFQE 273 >3C51-A nrPDB Length = 543 Score = 214 bits (546), Expect = 4e-56, Method: Composition-based stats. Identities = 78/344 (22%), Positives = 134/344 (38%), Gaps = 63/344 (18%) Query: 46 QRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKP 105 Q K LEA Q +GE D F LG G G VF K +G + A K ++ + Sbjct: 173 QWKWLEA-----QPMGE---DWFLDFRVLGRGGFGEVFACQMKATGKLYACKKLNKKRLK 224 Query: 106 AIR--NQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR--- 160 + + E ++L + +S +IV AF + ++ + M M+GG + + Sbjct: 225 KRKGYQGAMVEKKILAKVHSRFIVSLAYAFETKTDLCLVMTIMNGGDIRYHIYNVDEDNP 284 Query: 161 -IPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSM 219 E + ++ GL +L +++ I++RD+KP N+L++ G +++ D G++ +L Sbjct: 285 GFQEPRAIFYTAQIVSGLEHLHQRN-IIYRDLKPENVLLDDDGNVRISDLGLAVELKAGQ 343 Query: 220 ANS--FVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGC 277 + + GT +M+PE L G Y D +++G++L EM R P K Sbjct: 344 TKTKGYAGTPGFMAPELLLGEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKQ 403 Query: 278 QVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDF 337 +V A P FS +DF Sbjct: 404 RVLEQAVTYP----------------------------------------DKFSPASKDF 423 Query: 338 VNKCLIKNPAERA-----DLKQLMVHAFIKRSDAEEVDFAGWLC 376 L K+P +R L H + +++ AG L Sbjct: 424 CEALLQKDPEKRLGFRDGSCDGLRTHPLFRDISWRQLE-AGMLT 466 >4XUF-A nrPDB Length = 297 Score = 214 bits (545), Expect = 5e-56, Method: Composition-based stats. Identities = 63/285 (22%), Positives = 111/285 (38%), Gaps = 37/285 (12%) Query: 61 GELKDDDFEKISELGAGNGGVV-----FKVSHKPSGLVMARKLIHLEIKPAIRNQIIREL 115 E ++ E LG+G G V + +S + +A K++ + + R ++ EL Sbjct: 4 WEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSEL 63 Query: 116 QVLHEC-NSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLK-KAGRIPEQILGK----- 168 +++ + + IV GA G I + E+ G L L+ K + E + Sbjct: 64 KMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKR 123 Query: 169 -----------------VSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGV 211 + V KG+ +L K +HRD+ N+LV +K+CDFG+ Sbjct: 124 LEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFK-SCVHRDLAARNVLVTHGKVVKICDFGL 182 Query: 212 SGQLIDSMANSFVGTRS----YMSPERLQGTHYSVQSDIWSMGLSLVEMAV-GRYPIP-- 264 + ++ G +M+PE L Y+++SD+WS G+ L E+ G P P Sbjct: 183 ARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGI 242 Query: 265 PPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMA 309 P DA +L+ + ++ RP Sbjct: 243 PVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFP 287 >5MJB-A nrPDB Length = 305 Score = 214 bits (545), Expect = 5e-56, Method: Composition-based stats. Identities = 62/272 (22%), Positives = 105/272 (38%), Gaps = 14/272 (5%) Query: 69 EKISELGAGNGGVVFKVSHKPSGL---VMARKLIHLEIKPAIRNQIIRELQVLHECNSPY 125 + +GAG G V+K K G +A K + R + E ++ + + Sbjct: 29 KIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHRN 88 Query: 126 IVGFYGAFYSDGEISICMEHMDGGSLDQVLKKA-GRIPEQILGKVSIAVIKGLTYLREKH 184 I+ G + I E M+ +LD L++ G+ L + + G+ YL E + Sbjct: 89 IIRLEGVVTKSRPVMIITEFMENCALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLSEMN 148 Query: 185 KIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS----MANSFVGTR---SYMSPERLQG 237 + HRD+ NILVNS K+ DFG+S L D S +G + + +PE + Sbjct: 149 YV-HRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIAY 207 Query: 238 THYSVQSDIWSMGLSLVE-MAVGRYPIPPPDAKELELMFGCQVE-GDAAETPPRPRTPGR 295 ++ SD+WS G+ + E M+ G P +++ + P Sbjct: 208 RKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPAALHQLML 267 Query: 296 PLSSYGMDSRPPMAIFELLDYIVNEPPPKLPS 327 +SRP A + P L + Sbjct: 268 DCWQKDRNSRPRFAEIVNTLDKMIRNPASLKT 299 >5X02-A nrPDB Length = 347 Score = 214 bits (544), Expect = 6e-56, Method: Composition-based stats. Identities = 63/285 (22%), Positives = 111/285 (38%), Gaps = 37/285 (12%) Query: 61 GELKDDDFEKISELGAGNGGVV-----FKVSHKPSGLVMARKLIHLEIKPAIRNQIIREL 115 E ++ E LG+G G V + +S + +A K++ + + R ++ EL Sbjct: 43 WEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSEL 102 Query: 116 QVLHEC-NSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLK-KAGRIPEQILGK----- 168 +++ + + IV GA G I + E+ G L L+ K + E + Sbjct: 103 KMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKR 162 Query: 169 -----------------VSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGV 211 + V KG+ +L K +HRD+ N+LV +K+CDFG+ Sbjct: 163 LEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFK-SCVHRDLAARNVLVTHGKVVKICDFGL 221 Query: 212 SGQLIDSMANSFVGTRS----YMSPERLQGTHYSVQSDIWSMGLSLVEMAV-GRYPIP-- 264 + ++ G +M+PE L Y+++SD+WS G+ L E+ G P P Sbjct: 222 ARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGI 281 Query: 265 PPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMA 309 P DA +L+ + ++ RP Sbjct: 282 PVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFP 326 >4P5Q-A nrPDB Length = 361 Score = 214 bits (544), Expect = 7e-56, Method: Composition-based stats. Identities = 65/272 (23%), Positives = 109/272 (40%), Gaps = 13/272 (4%) Query: 62 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLV---MARKLIHLEIKPAIRNQIIRELQVL 118 EL + +GAG G V K +A K + + R + E ++ Sbjct: 29 ELDATNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIM 88 Query: 119 HECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAG-RIPEQILGKVSIAVIKGL 177 + + P I+ G + I E+M+ GSLD L+K + L + + G+ Sbjct: 89 GQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGM 148 Query: 178 TYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSM--ANSFVGTR---SYMSP 232 YL +HRD+ NIL+NS K+ DFG+S L D A + G + + SP Sbjct: 149 KYL-SDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSP 207 Query: 233 ERLQGTHYSVQSDIWSMGLSLVE-MAVGRYPIPPPDAKE-LELMFGCQVEGDAAETPPRP 290 E + ++ SD+WS G+ L E M+ G P ++ ++ + + P Sbjct: 208 EAIAYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCPAAL 267 Query: 291 RTPGRPLSSYGMDSRPPM-AIFELLDYIVNEP 321 ++RP I +LD ++ P Sbjct: 268 YQLMLDCWQKDRNNRPKFEQIVSILDKLIRNP 299 >6E4F-A nrPDB Length = 290 Score = 213 bits (543), Expect = 8e-56, Method: Composition-based stats. Identities = 68/257 (26%), Positives = 110/257 (42%), Gaps = 10/257 (3%) Query: 61 GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE 120 E+ D + ELG G GVV + +A K+I ++ I E +V+ Sbjct: 26 WEIDPKDLTFLKELGTGQFGVVKYGKWRG-QYDVAIKMIKE--GSMSEDEFIEEAKVMMN 82 Query: 121 CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKK-AGRIPEQILGKVSIAVIKGLTY 179 + +V YG I I E+M G L L++ R Q L ++ V + + Y Sbjct: 83 LSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEY 142 Query: 180 LREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTR---SYMSPERLQ 236 L K + +HRD+ N LVN +G +K+ DFG+S ++D S VG++ + PE L Sbjct: 143 LESK-QFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLM 201 Query: 237 GTHYSVQSDIWSMGLSLVEM-AVGRYPIPPPDAKEL-ELMFGCQVEGDAAETPPRPRTPG 294 + +S +SDIW+ G+ + E+ ++G+ P E E + + T Sbjct: 202 YSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIM 261 Query: 295 RPLSSYGMDSRPPMAIF 311 D RP I Sbjct: 262 YSCWHEKADERPTFKIL 278 >2Y6O-A nrPDB Length = 291 Score = 213 bits (543), Expect = 9e-56, Method: Composition-based stats. Identities = 67/283 (23%), Positives = 111/283 (39%), Gaps = 13/283 (4%) Query: 62 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLV---MARKLIHLEIKPAIRNQIIRELQVL 118 E+ + +G G G V K G +A K + R + E ++ Sbjct: 10 EIDASCIKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIM 69 Query: 119 HECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKA-GRIPEQILGKVSIAVIKGL 177 + + P I+ G + I E+M+ GSLD L+K GR L + + G+ Sbjct: 70 GQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGM 129 Query: 178 TYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSM--ANSFVGTR---SYMSP 232 YL + + HRD+ NILVNS K+ DFG+S L D A + G + + +P Sbjct: 130 KYLSDMSYV-HRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAP 188 Query: 233 ERLQGTHYSVQSDIWSMGLSLVE-MAVGRYPIPPPDAKE-LELMFGCQVEGDAAETPPRP 290 E + ++ SD+WS G+ + E M+ G P ++ ++ + + P Sbjct: 189 EAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPPMDCPIAL 248 Query: 291 RTPGRPLSSYGMDSRPPMA-IFELLDYIVNEPPPKLPSGVFSL 332 RP I +LD ++ P +G S Sbjct: 249 HQLMLDCWQKERSDRPKFGQIVNMLDKLIRNPNSLKRTGSESS 291 >6O6Q-A nrPDB Length = 335 Score = 213 bits (543), Expect = 9e-56, Method: Composition-based stats. Identities = 66/307 (21%), Positives = 118/307 (38%), Gaps = 27/307 (8%) Query: 64 KDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHEC-N 122 +++E + +LG G VF + K++ P R +I RE+ +L + Sbjct: 39 PQENYEILRKLGRGKYSEVFLGIDLEKREKVVIKVLK----PVKRKKIKREISILKNLVD 94 Query: 123 SPYIVGFYGAFYSDGEIS--ICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL 180 P I+ + + EH++ + + + ++K L Y Sbjct: 95 GPNIIAMLDVVREPQSKTPGLIFEHINNIDFRSL---YPTFTDYDIRFYMYELLKALDYS 151 Query: 181 REKHKIMHRDVKPSNILVNSRGEI-KLCDFGVSGQLI-DSMANSFVGTRSYMSPERL-QG 237 IMHRDVKP N++++ ++ +L D+G++ + N V +R + PE L Sbjct: 152 HSM-GIMHRDVKPHNVMIDHDKKLLRLIDWGLAEYYHPGTEYNVRVASRYFKGPELLVDY 210 Query: 238 THYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPR---TPG 294 Y D+WS G L M + P + +L+ +V G + + G Sbjct: 211 RLYDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQLVQIVRVLGSKNFKKYLEKYNISLG 270 Query: 295 RPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQ 354 G ++ F +NE L S EF D +++ L + ER K+ Sbjct: 271 EEYEDIGYYNKRQWVRF------MNENNKDL----VSQEFLDLIDRLLRYDHQERLTAKE 320 Query: 355 LMVHAFI 361 M HA+ Sbjct: 321 AMKHAYF 327 >2H8H-A nrPDB Length = 535 Score = 213 bits (543), Expect = 1e-55, Method: Composition-based stats. Identities = 64/318 (20%), Positives = 117/318 (36%), Gaps = 56/318 (17%) Query: 58 QKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQV 117 + E+ + +LG G G V+ + + +A K + ++E QV Sbjct: 259 KDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGT--MSPEAFLQEAQV 315 Query: 118 LHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLK--KAGRIPEQILGKVSIAVIK 175 + + +V Y S+ I I E+M GSL LK + L ++ + Sbjct: 316 MKKLRHEKLVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIAS 374 Query: 176 GLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTR---SYMSP 232 G+ Y+ E+ +HRD++ +NILV K+ DFG++ + D+ + G + + +P Sbjct: 375 GMAYV-ERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAP 433 Query: 233 ERLQGTHYSVQSDIWSMGLSLVEMAV-GRYPIPPPDAKELELMFGCQVEGDAAETPPRPR 291 E ++++SD+WS G+ L E+ GR P P +E+ G PP Sbjct: 434 EAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREV---LDQVERGYRMPCPPEC- 489 Query: 292 TPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERAD 351 D + +C K P ER Sbjct: 490 ---------------------------------------PESLHDLMCQCWRKEPEERPT 510 Query: 352 LK--QLMVHAFIKRSDAE 367 + Q + + ++ + Sbjct: 511 FEYLQAFLEDYFTSTEPQ 528 >6F3F-A nrPDB Length = 455 Score = 213 bits (542), Expect = 1e-55, Method: Composition-based stats. Identities = 65/318 (20%), Positives = 118/318 (37%), Gaps = 56/318 (17%) Query: 58 QKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQV 117 + E+ + +LG G G V+ + + +A K + ++E QV Sbjct: 179 KDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGT--MSPEAFLQEAQV 235 Query: 118 LHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLK--KAGRIPEQILGKVSIAVIK 175 + + +V Y S+ I I E+M+ GSL LK + L +S + Sbjct: 236 MKKLRHEKLVQLYAVV-SEEPIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIAS 294 Query: 176 GLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTR---SYMSP 232 G+ Y+ E+ +HRD++ +NILV K+ DFG++ + D+ + G + + +P Sbjct: 295 GMAYV-ERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAP 353 Query: 233 ERLQGTHYSVQSDIWSMGLSLVEMAV-GRYPIPPPDAKELELMFGCQVEGDAAETPPRPR 291 E ++++SD+WS G+ L E+ GR P P +E+ G PP Sbjct: 354 EAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREV---LDQVERGYRMPCPPEC- 409 Query: 292 TPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERAD 351 D + +C K P ER Sbjct: 410 ---------------------------------------PESLHDLMCQCWRKEPEERPT 430 Query: 352 LK--QLMVHAFIKRSDAE 367 + Q + + ++ + Sbjct: 431 FEYLQAFLEDYFTSTEPQ 448 >6E2O-A nrPDB Length = 295 Score = 213 bits (542), Expect = 1e-55, Method: Composition-based stats. Identities = 87/314 (27%), Positives = 146/314 (46%), Gaps = 56/314 (17%) Query: 62 ELKDDDFEKIS-----ELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQ 116 +L + D+E LG G G+V+ + + +A K I + + E+ Sbjct: 13 DLLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQP-LHEEIA 71 Query: 117 VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLK-KAGRI--PEQILGKVSIAV 173 + IV + G+F +G I I ME + GGSL +L+ K G + EQ +G + + Sbjct: 72 LHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQI 131 Query: 174 IKGLTYLREKHKIMHRDVKPSNILVNS-RGEIKLCDFGVSGQL--IDSMANSFVGTRSYM 230 ++GL YL + ++I+HRD+K N+L+N+ G +K+ DFG S +L I+ +F GT YM Sbjct: 132 LEGLKYLHD-NQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYM 190 Query: 231 SPERLQG--THYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPP 288 +PE + Y +DIWS+G +++EMA G+ P Sbjct: 191 APEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGE-------------------- 230 Query: 289 RPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAE 348 P A+F++ + V+ P++P + S E + F+ KC +P + Sbjct: 231 -----------------PQAAMFKVGMFKVH---PEIPESM-SAEAKAFILKCFEPDPDK 269 Query: 349 RADLKQLMVHAFIK 362 RA L+V F+K Sbjct: 270 RACANDLLVDEFLK 283 >3SXS-A nrPDB Length = 268 Score = 213 bits (541), Expect = 1e-55, Method: Composition-based stats. Identities = 65/252 (25%), Positives = 113/252 (44%), Gaps = 12/252 (4%) Query: 60 VGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLH 119 ELK ++ + ELG+G GVV K +A K+I ++ +E Q + Sbjct: 2 HMELKREEITLLKELGSGQFGVVKLGKWKG-QYDVAVKMIKE--GSMSEDEFFQEAQTMM 58 Query: 120 ECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR-IPEQILGKVSIAVIKGLT 178 + + P +V FYG + I I E++ G L L+ G+ + L ++ V +G+ Sbjct: 59 KLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMA 118 Query: 179 YLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTR---SYMSPERL 235 +L E H+ +HRD+ N LV+ +K+ DFG++ ++D S VGT+ + +PE Sbjct: 119 FL-ESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVF 177 Query: 236 QGTHYSVQSDIWSMGLSLVE-MAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPG 294 YS +SD+W+ G+ + E ++G+ P E+ L +G P Sbjct: 178 HYFKYSSKSDVWAFGILMWEVFSLGKMPYDLYTNSEVVL---KVSQGHRLYRPHLASDTI 234 Query: 295 RPLSSYGMDSRP 306 + P Sbjct: 235 YQIMYSCWHELP 246 >2WTK-B nrPDB Length = 373 Score = 213 bits (541), Expect = 1e-55, Method: Composition-based stats. Identities = 81/343 (23%), Positives = 139/343 (40%), Gaps = 35/343 (10%) Query: 68 FEKISELGAGNG---GVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIR-ELQVLHECNS 123 +E ++ +G G V +KP+G + + I+LE ++ EL V N Sbjct: 11 YELLTVIGKG-FEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNH 69 Query: 124 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVL--KKAGRIPEQILGKVSIAVIKGLTYLR 181 P IV + F +D E+ + M GS ++ + E + + V+K L Y+ Sbjct: 70 PNIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALDYIH 129 Query: 182 EKHKIMHRDVKPSNILVNSRGEIKLCDF---------GVSGQLIDSMANSFVGTRSYMSP 232 +HR VK S+IL++ G++ L G +++ V ++SP Sbjct: 130 HM-GYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSVKVLPWLSP 188 Query: 233 ERLQGT--HYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMF-----GCQVEGDAAE 285 E LQ Y +SDI+S+G++ E+A G P A ++ L C ++ Sbjct: 189 EVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPCLLDTSTIP 248 Query: 286 TPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSG-VFSLEFQDFVNKCLIK 344 +P R +++ G+ ++ N P P FS F FV +CL + Sbjct: 249 AEELTMSPSRSVANSGLSD----SLTTSTPRPSNGDSPSHPYHRTFSPHFHHFVEQCLQR 304 Query: 345 NPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQPSTP 387 NP R L+ H+F K+ + + L +P TP Sbjct: 305 NPDARPSASTLLNHSFFKQIKRRASE------ALPELLRPVTP 341 >1JPA-A nrPDB Length = 312 Score = 213 bits (541), Expect = 2e-55, Method: Composition-based stats. Identities = 61/272 (22%), Positives = 104/272 (38%), Gaps = 14/272 (5%) Query: 69 EKISELGAGNGGVVFKVSHKPSGLV---MARKLIHLEIKPAIRNQIIRELQVLHECNSPY 125 + +GAG G V K G +A K + R + E ++ + + P Sbjct: 36 KIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPN 95 Query: 126 IVGFYGAFYSDGEISICMEHMDGGSLDQVLKKA-GRIPEQILGKVSIAVIKGLTYLREKH 184 ++ G + I E M+ GSLD L++ G+ L + + G+ YL + + Sbjct: 96 VIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLADMN 155 Query: 185 KIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS----MANSFVGTR---SYMSPERLQG 237 + HRD+ NILVNS K+ DFG+S L D S +G + + +PE +Q Sbjct: 156 YV-HRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQY 214 Query: 238 THYSVQSDIWSMGLSLVE-MAVGRYPIPPPDAKELELMFGCQVE-GDAAETPPRPRTPGR 295 ++ SD+WS G+ + E M+ G P +++ + P Sbjct: 215 RKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLML 274 Query: 296 PLSSYGMDSRPPMAIFELLDYIVNEPPPKLPS 327 + RP + P L + Sbjct: 275 DCWQKDRNHRPKFGQIVNTLDKMIRNPNSLKA 306 >3DKO-A nrPDB Length = 318 Score = 212 bits (540), Expect = 2e-55, Method: Composition-based stats. Identities = 64/273 (23%), Positives = 109/273 (39%), Gaps = 13/273 (4%) Query: 62 ELKDDDFEKISELGAGNGGVVFKVSHKPSGL---VMARKLIHLEIKPAIRNQIIRELQVL 118 EL + +GAG G V K G +A K + + R + E ++ Sbjct: 39 ELDASCIKIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIM 98 Query: 119 HECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKA-GRIPEQILGKVSIAVIKGL 177 + + P +V G + I +E M+ G+LD L+K G+ L + + G+ Sbjct: 99 GQFDHPNVVHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGM 158 Query: 178 TYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGT-----RSYMSP 232 YL + +HRD+ NILVNS K+ DFG+S + D + T + +P Sbjct: 159 RYLADM-GYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAP 217 Query: 233 ERLQGTHYSVQSDIWSMGLSLVE-MAVGRYPIPPPDAKE-LELMFGCQVEGDAAETPPRP 290 E +Q ++ SD+WS G+ + E M+ G P ++ ++ + + P Sbjct: 218 EAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPAPMDCPAGL 277 Query: 291 RTPGRPLSSYGMDSRPPM-AIFELLDYIVNEPP 322 RP I +LD ++ P Sbjct: 278 HQLMLDCWQKERAERPKFEQIVGILDKMIRNPN 310 >6BXI-A nrPDB Length = 333 Score = 212 bits (540), Expect = 2e-55, Method: Composition-based stats. Identities = 62/263 (23%), Positives = 104/263 (39%), Gaps = 40/263 (15%) Query: 62 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE--IKPAIRNQIIRELQVLH 119 L +DFE + +G G G V V K +G V A K++ ++ I E +L Sbjct: 2 RLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILV 61 Query: 120 ECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTY 179 E +S ++V + +F + + ME + GG + +L K + E+ + + Sbjct: 62 EADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDS 121 Query: 180 LREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSF---------------- 223 + + +HRD+KP N+L++S+G +KL DFG+ L + F Sbjct: 122 IHQL-GFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQN 180 Query: 224 ---------------------VGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYP 262 VGT Y++PE T Y+ D WS+G+ + EM +G P Sbjct: 181 MNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPP 240 Query: 263 IPPPDAKELELMFGCQVEGDAAE 285 +E E Sbjct: 241 FCSETPQETYKKVMNWKETLTFP 263 >5KMM-A nrPDB Length = 329 Score = 212 bits (539), Expect = 2e-55, Method: Composition-based stats. Identities = 69/281 (24%), Positives = 107/281 (38%), Gaps = 31/281 (11%) Query: 60 VGELKDDDFEKISELGAGNGGVVFKVSH-----KPSGLVMARKLIHLEIKPAIRNQIIRE 114 V +K D ELG G G VF + +++A K + E + R RE Sbjct: 29 VHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALK-EASESARQDFQRE 87 Query: 115 LQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKA---------------G 159 ++L +IV F+G + + E+M G L++ L+ G Sbjct: 88 AELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPG 147 Query: 160 RIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSM 219 + L V+ V G+ YL H +HRD+ N LV +K+ DFG+S + + Sbjct: 148 PLGLGQLLAVASQVAAGMVYLAGLH-FVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTD 206 Query: 220 ANSFVGT----RSYMSPERLQGTHYSVQSDIWSMGLSLVEMAV-GRYPIPPPDAKELELM 274 G +M PE + ++ +SD+WS G+ L E+ G+ P E Sbjct: 207 YYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTE---A 263 Query: 275 FGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLD 315 C +G E P R P G R P + D Sbjct: 264 IDCITQGRELERP-RACPPEVYAIMRGCWQREPQQRHSIKD 303 >4EQM-A nrPDB Length = 294 Score = 212 bits (539), Expect = 3e-55, Method: Composition-based stats. Identities = 54/217 (24%), Positives = 103/217 (47%), Gaps = 6/217 (2%) Query: 57 KQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARK--LIHLEIKPAIRNQIIRE 114 +G++ ++ ++ + +LG G V+ + +A K I K + RE Sbjct: 2 SHMIGKIINERYKIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETLKRFERE 61 Query: 115 LQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVI 174 + + + IV D + ME+++G +L + ++ G + + ++ Sbjct: 62 VHNSSQLSHQNIVSMIDVDEEDDCYYLVMEYIEGPTLSEYIESHGPLSVDTAINFTNQIL 121 Query: 175 KGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID---SMANSFVGTRSYMS 231 G+ + + +I+HRD+KP NIL++S +K+ DFG++ L + + N +GT Y S Sbjct: 122 DGIKHAHDM-RIVHRDIKPQNILIDSNKTLKIFDFGIAKALSETSLTQTNHVLGTVQYFS 180 Query: 232 PERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDA 268 PE+ +G +DI+S+G+ L EM VG P A Sbjct: 181 PEQAKGEATDECTDIYSIGIVLYEMLVGEPPFNGETA 217 >3QGY-A nrPDB Length = 286 Score = 211 bits (537), Expect = 4e-55, Method: Composition-based stats. Identities = 62/249 (24%), Positives = 105/249 (42%), Gaps = 12/249 (4%) Query: 63 LKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECN 122 + + + E+G+G G+V +A K I + I E +V+ + + Sbjct: 24 IDPSELTFVQEIGSGQFGLVHLGYWLNKDK-VAIKTIKE--GSMSEDDFIEEAEVMMKLS 80 Query: 123 SPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLK-KAGRIPEQILGKVSIAVIKGLTYLR 181 P +V YG I + E M+ G L L+ + G + L + + V +G+ YL Sbjct: 81 HPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLE 140 Query: 182 EKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTR---SYMSPERLQGT 238 E ++HRD+ N LV IK+ DFG++ ++D S GT+ + SPE + Sbjct: 141 EAC-VIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFS 199 Query: 239 HYSVQSDIWSMGLSLVEMAV-GRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPL 297 YS +SD+WS G+ + E+ G+ P E+ G P T + Sbjct: 200 RYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDIS---TGFRLYKPRLASTHVYQI 256 Query: 298 SSYGMDSRP 306 ++ RP Sbjct: 257 MNHCWKERP 265 >5X5O-A nrPDB Length = 310 Score = 211 bits (536), Expect = 6e-55, Method: Composition-based stats. Identities = 67/306 (21%), Positives = 113/306 (36%), Gaps = 55/306 (17%) Query: 54 LTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIR 113 + ++K DD + G G+ G V++ +A K + I + Sbjct: 3 MGSGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLK---------IEK 53 Query: 114 ELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLK--KAGRIPEQILGKVSI 171 E ++L + I+ FYG I E+ GSL + ++ + + + Sbjct: 54 EAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWAT 113 Query: 172 AVIKGLTYLREKH--KIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSY 229 V KG+ YL + K++HRD+K N+++ + G +K+CDFG S + S VGT + Sbjct: 114 DVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTFPW 173 Query: 230 MSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPR 289 M+PE +Q S D +S G+ L EM P + G QV E R Sbjct: 174 MAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLE--------GLQVAWLVVEKNER 225 Query: 290 PRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAER 349 P S F + +++C + +R Sbjct: 226 LTIPSSCPRS----------------------------------FAELLHQCWEADAKKR 251 Query: 350 ADLKQL 355 KQ+ Sbjct: 252 PSFKQI 257 >4Y93-A nrPDB Length = 446 Score = 211 bits (536), Expect = 6e-55, Method: Composition-based stats. Identities = 67/257 (26%), Positives = 109/257 (42%), Gaps = 10/257 (3%) Query: 61 GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE 120 E+ D + ELG G GVV + +A K+I ++ I E +V+ Sbjct: 183 WEIDPKDLTFLKELGTGQFGVVKYGKWRG-QYDVAIKMIKE--GSMSEDEFIEEAKVMMN 239 Query: 121 CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKK-AGRIPEQILGKVSIAVIKGLTY 179 + +V YG I I E+M G L L++ R Q L ++ V + + Y Sbjct: 240 LSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEY 299 Query: 180 LREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTR---SYMSPERLQ 236 L K + +HRD+ N LVN +G +K+ DFG++ ++D S G++ + SPE L Sbjct: 300 LESK-QFLHRDLAARNCLVNDQGVVKVSDFGMTRYVLDDEYTSSTGSKFPVKWASPEVLM 358 Query: 237 GTHYSVQSDIWSMGLSLVEM-AVGRYPIPPPDAKEL-ELMFGCQVEGDAAETPPRPRTPG 294 + +S +SDIW+ G+ + E+ ++G+ P E E + R Sbjct: 359 YSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLPRPHLASERVYAIM 418 Query: 295 RPLSSYGMDSRPPMAIF 311 D RP I Sbjct: 419 YSCWHEKADERPTFKIL 435 >2R2P-A nrPDB Length = 295 Score = 211 bits (536), Expect = 6e-55, Method: Composition-based stats. Identities = 65/272 (23%), Positives = 109/272 (40%), Gaps = 13/272 (4%) Query: 62 ELKDDDFEKISELGAGNGGVVFKVSHKPSGL---VMARKLIHLEIKPAIRNQIIRELQVL 118 E++ +GAG G V K G +A K + + R + E ++ Sbjct: 18 EIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIM 77 Query: 119 HECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKA-GRIPEQILGKVSIAVIKGL 177 + + P I+ G + I E+M+ GSLD LKK G+ L + + G+ Sbjct: 78 GQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGISAGM 137 Query: 178 TYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSM--ANSFVGTR---SYMSP 232 YL +HRD+ NIL+NS K+ DFG+S L D A + G + + +P Sbjct: 138 KYL-SDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAP 196 Query: 233 ERLQGTHYSVQSDIWSMGLSLVEMA-VGRYPIPPP-DAKELELMFGCQVEGDAAETPPRP 290 E + ++ SD+WS G+ + E+ G P + ++ + + P Sbjct: 197 EAIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPAAL 256 Query: 291 RTPGRPLSSYGMDSRPPM-AIFELLDYIVNEP 321 +SRP I +LD ++ P Sbjct: 257 YQLMLDCWQKERNSRPKFDEIVNMLDKLIRNP 288 >5SYS-A nrPDB Length = 286 Score = 210 bits (535), Expect = 7e-55, Method: Composition-based stats. Identities = 63/318 (19%), Positives = 117/318 (36%), Gaps = 56/318 (17%) Query: 58 QKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQV 117 + E+ + +LG G G + + + +A K + ++E QV Sbjct: 10 KDAWEIPRESLRLEVKLGQGCFGECWMGTWNGTTR-VAIKTLKPGT--MSPEAFLQEAQV 66 Query: 118 LHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLK--KAGRIPEQILGKVSIAVIK 175 + + +V Y S+ I I E+M GSL LK + L ++ + Sbjct: 67 MKKLRHEKLVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIAS 125 Query: 176 GLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTR---SYMSP 232 G+ Y+ E+ +HRD++ +NILV K+ DFG++ + D+ + G + + +P Sbjct: 126 GMAYV-ERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAP 184 Query: 233 ERLQGTHYSVQSDIWSMGLSLVEMAV-GRYPIPPPDAKELELMFGCQVEGDAAETPPRPR 291 E ++++SD+WS G+ L E+ GR P P +E+ G PP Sbjct: 185 EAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREV---LDQVERGYRMPCPPEC- 240 Query: 292 TPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERAD 351 D + +C K+P ER Sbjct: 241 ---------------------------------------PESLHDLMCQCWRKDPEERPT 261 Query: 352 LK--QLMVHAFIKRSDAE 367 + Q + + ++ + Sbjct: 262 FEYLQAFLEDYFTSTEPQ 279 >6FEX-A nrPDB Length = 321 Score = 210 bits (534), Expect = 1e-54, Method: Composition-based stats. Identities = 65/338 (19%), Positives = 115/338 (34%), Gaps = 74/338 (21%) Query: 62 ELKDDDFEKISELGAGNGGVVFKVS----------------HKPSGLVMARKLIHLEIKP 105 + +LG G G V K L++A K++ + Sbjct: 12 DFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATK 71 Query: 106 AIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAG------ 159 RN ++E++++ P I+ G D + + ++M+ G L+Q L Sbjct: 72 NARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAA 131 Query: 160 -------RIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVS 212 I +L V+ + G+ YL + +HRD+ N LV IK+ DFG+S Sbjct: 132 EGAPGDPTISYPMLLHVAAQIASGMRYLATLN-FVHRDLATRNCLVGENFTIKIADFGMS 190 Query: 213 GQLIDSMANSFVGTR----SYMSPERLQGTHYSVQSDIWSMGLSLVE--MAVGRYPIPPP 266 L G +M+ E + ++ SD+W+ G++L E M P Sbjct: 191 RNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQL 250 Query: 267 DAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLP 326 + QV +A E + + PP P Sbjct: 251 TDE--------QVIENAGEF-----------------------FRDQGRQVYLSRPPACP 279 Query: 327 SGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRS 364 G++ + + +C + +R QL H F+ Sbjct: 280 QGLY-----ELMLRCWSRESEQRPPFSQL--HRFLAED 310 >3A4O-X nrPDB Length = 286 Score = 209 bits (532), Expect = 2e-54, Method: Composition-based stats. Identities = 57/259 (22%), Positives = 108/259 (41%), Gaps = 11/259 (4%) Query: 57 KQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQ 116 + E+ + + + LGAG G V+ + S +A K + + E Sbjct: 4 DKDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTK-VAVKTLKPGTMSV--QAFLEEAN 60 Query: 117 VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLK--KAGRIPEQILGKVSIAVI 174 ++ +V Y + I I E+M GSL LK + G++ L S + Sbjct: 61 LMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIA 120 Query: 175 KGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTR---SYMS 231 +G+ Y+ K+ I HRD++ +N+LV+ K+ DFG++ + D+ + G + + + Sbjct: 121 EGMAYIERKNYI-HRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTA 179 Query: 232 PERLQGTHYSVQSDIWSMGLSLVEMAV-GRYPIPP-PDAKELELMFGCQVEGDAAETPPR 289 PE + ++++SD+WS G+ L E+ G+ P P +A + + P Sbjct: 180 PEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDE 239 Query: 290 PRTPGRPLSSYGMDSRPPM 308 + + RP Sbjct: 240 LYDIMKMCWKEKAEERPTF 258 >5L6P-A nrPDB Length = 298 Score = 209 bits (532), Expect = 2e-54, Method: Composition-based stats. Identities = 60/271 (22%), Positives = 103/271 (38%), Gaps = 14/271 (5%) Query: 69 EKISELGAGNGGVVFKVSHKPSGLV---MARKLIHLEIKPAIRNQIIRELQVLHECNSPY 125 + +GAG G V + K G +A K + + R + E ++ + + P Sbjct: 22 KIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQRRDFLSEASIMGQFDHPN 81 Query: 126 IVGFYGAFYSDGEISICMEHMDGGSLDQVLK-KAGRIPEQILGKVSIAVIKGLTYLREKH 184 I+ G + I E M+ +LD L+ G+ L + + G+ YL E + Sbjct: 82 IIRLEGVVTKSRPVMILTEFMENCALDSFLRLNDGQFTVIQLVGMLRGIAAGMKYLSEMN 141 Query: 185 KIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS----MANSFVGTR---SYMSPERLQG 237 + HRD+ NILVNS K+ DFG+S L D S +G + + +PE + Sbjct: 142 YV-HRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTAPEAIAY 200 Query: 238 THYSVQSDIWSMGLSLVE-MAVGRYPIPPPDAKELELMFGCQVE-GDAAETPPRPRTPGR 295 ++ SD+WS G+ + E M+ G P +++ + P Sbjct: 201 RKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVEQDYRLPPPMDCPTALHQLML 260 Query: 296 PLSSYGMDSRPPMAIFELLDYIVNEPPPKLP 326 + RP + + P L Sbjct: 261 DCWVRDRNLRPKFSQIVNTLDKLIRNPASLK 291 >3RAW-A nrPDB Length = 381 Score = 209 bits (532), Expect = 2e-54, Method: Composition-based stats. Identities = 67/339 (19%), Positives = 126/339 (37%), Gaps = 29/339 (8%) Query: 59 KVGELKDDDFEKISELGAGNGGVVFKV-SHKPSGLVMARKLIHL--EIKPAIRNQI--IR 113 ++G+ + +E + LG G G V + H +A K+I + + A R +I ++ Sbjct: 44 RIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLK 103 Query: 114 ELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAG--RIPEQILGKVSI 171 +++ + N V F G + I E + G + + LK+ P + ++ Sbjct: 104 KIKEKDKENKFLCVLMSDWFNFHGHMCIAFELL-GKNTFEFLKENNFQPYPLPHVRHMAY 162 Query: 172 AVIKGLTYLREKHKIMHRDVKPSNILVN-------------------SRGEIKLCDFGVS 212 + L +L E +++ H D+KP NIL I++ DFG + Sbjct: 163 QLCHALRFLHE-NQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSA 221 Query: 213 GQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELE 272 + V TR Y PE + ++ D+WS+G L E G + +E Sbjct: 222 T-FDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHL 280 Query: 273 LMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSL 332 +M + + R R + + + L + + Sbjct: 281 VMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHV 340 Query: 333 EFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDF 371 + D + + L +PA+R L + ++H F EE F Sbjct: 341 QLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSF 379 >2DQ7-X nrPDB Length = 283 Score = 209 bits (532), Expect = 2e-54, Method: Composition-based stats. Identities = 64/318 (20%), Positives = 120/318 (37%), Gaps = 56/318 (17%) Query: 58 QKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQV 117 + V E+ + + I LG G G V+ + +A K + + E Q+ Sbjct: 1 KDVWEIPRESLQLIKRLGNGQFGEVWMGTWNG-NTKVAIKTLKPGT--MSPESFLEEAQI 57 Query: 118 LHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLK--KAGRIPEQILGKVSIAVIK 175 + + +V Y S+ I I E+M+ GSL LK + + L ++ V Sbjct: 58 MKKLKHDKLVQLYAVV-SEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAA 116 Query: 176 GLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTR---SYMSP 232 G+ Y+ E+ +HRD++ +NILV + K+ DFG++ + D+ + G + + +P Sbjct: 117 GMAYI-ERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAP 175 Query: 233 ERLQGTHYSVQSDIWSMGLSLVEMAV-GRYPIPPPDAKELELMFGCQVEGDAAETPPRPR 291 E ++++SD+WS G+ L E+ GR P P + +E+ G P Sbjct: 176 EAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREV---LEQVERGYRMPCPQDCP 232 Query: 292 TPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERAD 351 + + C K+P ER Sbjct: 233 I----------------------------------------SLHELMIHCWKKDPEERPT 252 Query: 352 LK--QLMVHAFIKRSDAE 367 + Q + + ++ + Sbjct: 253 FEYLQSFLEDYFTATEPQ 270 >2WO6-A nrPDB Length = 382 Score = 209 bits (531), Expect = 2e-54, Method: Composition-based stats. Identities = 84/342 (24%), Positives = 133/342 (38%), Gaps = 37/342 (10%) Query: 58 QKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQV 117 K GE D +E S +G G+ G V K + +A K+I K A NQ E+++ Sbjct: 46 VKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIK--NKKAFLNQAQIEVRL 103 Query: 118 LHECNSP------YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR--IPEQILGKV 169 L N YIV F + + E + +L +L+ + + K Sbjct: 104 LELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSY-NLYDLLRNTNFRGVSLNLTRKF 162 Query: 170 SIAVIKGLTYLRE-KHKIMHRDVKPSNILVN--SRGEIKLCDFGVSGQLIDSMANSFVGT 226 + + L +L + I+H D+KP NIL+ R IK+ DFG S QL + ++ + Sbjct: 163 AQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQ-YIQS 221 Query: 227 RSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAA-- 284 R Y SPE L G Y + D+WS+G LVEM G + + ++ +V G Sbjct: 222 RFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGAN-EVDQMNKIVEVLGIPPAH 280 Query: 285 ------------ETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFS- 331 E P + + +PP V P S Sbjct: 281 ILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESG 340 Query: 332 ------LEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAE 367 L+F+D + + L +P R + H+F K++ E Sbjct: 341 HTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADE 382 >4PDO-A nrPDB Length = 299 Score = 208 bits (530), Expect = 3e-54, Method: Composition-based stats. Identities = 58/250 (23%), Positives = 99/250 (39%), Gaps = 13/250 (5%) Query: 72 SELGAGNGGVVFKVSHKPS----GLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIV 127 +GAG G V+K K S + +A K + R + E ++ + + I+ Sbjct: 40 KVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQFSHHNII 99 Query: 128 GFYGAFYSDGEISICMEHMDGGSLDQVLKKA-GRIPEQILGKVSIAVIKGLTYLREKHKI 186 G + I E+M+ G+LD+ L++ G L + + G+ YL + + Sbjct: 100 RLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAGMKYLANMNYV 159 Query: 187 MHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGT-----RSYMSPERLQGTHYS 241 HRD+ NILVNS K+ DFG+S L D ++ + + +PE + ++ Sbjct: 160 -HRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYRKFT 218 Query: 242 VQSDIWSMGLSLVE-MAVGRYPIPPPDAKE-LELMFGCQVEGDAAETPPRPRTPGRPLSS 299 SD+WS G+ + E M G P E ++ + + P Sbjct: 219 SASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQCWQ 278 Query: 300 YGMDSRPPMA 309 RP A Sbjct: 279 QERARRPKFA 288 >3CJF-A nrPDB Length = 309 Score = 208 bits (530), Expect = 3e-54, Method: Composition-based stats. Identities = 73/345 (21%), Positives = 120/345 (34%), Gaps = 72/345 (20%) Query: 38 EELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVS-----HKPSGL 92 +EL LDE + L E D LG G G V + + Sbjct: 4 DELPLDEHCER-----LPYDASKWEFPRDRLNLGKPLGRGAFGQVIEADAFGIDKTATCR 58 Query: 93 VMARKLIHLEIKPAIRNQIIRELQVL-HECNSPYIVGFYGAFYSDG-EISICMEHMDGGS 150 +A K++ + ++ EL++L H + +V GA G + + +E G+ Sbjct: 59 TVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGN 118 Query: 151 LDQVLKKA------------GRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILV 198 L L+ + + L S V KG+ +L + K +HRD+ NIL+ Sbjct: 119 LSTYLRSKRNEFVPYKDLYKDFLTLEHLICYSFQVAKGMEFLASR-KCIHRDLAARNILL 177 Query: 199 NSRGEIKLCDFGVSGQLIDSMANSFVGTRS----YMSPERLQGTHYSVQSDIWSMGLSLV 254 + + +K+CDFG++ + G +M+PE + Y++QSD+WS G+ L Sbjct: 178 SEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLW 237 Query: 255 EMAV-GRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFEL 313 E+ G P P E EG P + P M L Sbjct: 238 EIFSLGASPYPGVKIDE--EFCRRLKEGTRMRAPDY--------------TTPEMYQTML 281 Query: 314 LDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVH 358 C P++R +L+ H Sbjct: 282 D--------------------------CWHGEPSQRPTFSELVEH 300 >4H1J-A nrPDB Length = 293 Score = 208 bits (529), Expect = 4e-54, Method: Composition-based stats. Identities = 60/255 (23%), Positives = 100/255 (39%), Gaps = 11/255 (4%) Query: 63 LKDDDFEKISELGAGNGGVVFKVS---HKPSGLVMARKLIHLEIKPAIRNQIIRELQVLH 119 + +D LG G G V++ HK + +A K + + + + E ++ Sbjct: 21 IAREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMK 80 Query: 120 ECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVL-KKAGRIPEQILGKVSIAVIKGLT 178 + P+IV G + I ME G L L + + L S+ + K + Sbjct: 81 NLDHPHIVKLIGIIEEE-PTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMA 139 Query: 179 YLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTR---SYMSPERL 235 YL + +HRD+ NILV S +KL DFG+S + D TR +MSPE + Sbjct: 140 YLESIN-CVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPESI 198 Query: 236 QGTHYSVQSDIWSMGLSLVEMA-VGRYPIPPPDAKELE-LMFGCQVEGDAAETPPRPRTP 293 ++ SD+W + + E+ G+ P + K++ ++ PP T Sbjct: 199 NFRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTL 258 Query: 294 GRPLSSYGMDSRPPM 308 Y RP Sbjct: 259 MTRCWDYDPSDRPRF 273 >3E3P-A nrPDB Length = 360 Score = 208 bits (529), Expect = 4e-54, Method: Composition-based stats. Identities = 81/318 (25%), Positives = 131/318 (41%), Gaps = 36/318 (11%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE---CN 122 D F+ G G G V K +G+ +A K + + P RN RELQ++ + + Sbjct: 23 DRFQVERMAGQGTFGTVQLGKEKSTGMSVAIKKVIQD--PRFRN---RELQIMQDLAVLH 77 Query: 123 SPYIVGFYGAFYSDGE-------ISICMEHMDGGSLDQ----VLKKAGRIPEQILGKVSI 171 P IV FY+ GE +++ ME++ +L + ++ P ++ Sbjct: 78 HPNIVQLQSYFYTLGERDRRDIYLNVVMEYVP-DTLHRCCRNYYRRQVAPPPILIKVFLF 136 Query: 172 AVIKGLTYLR-EKHKIMHRDVKPSNILVNS-RGEIKLCDFGVSGQLIDSMAN-SFVGTRS 228 +I+ + L + HRD+KP N+LVN G +KLCDFG + +L S N +++ +R Sbjct: 137 QLIRSIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKLSPSEPNVAYICSRY 196 Query: 229 YMSPERLQGT-HYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETP 287 Y +PE + G HY+ DIWS+G EM +G PI D +L +V G + Sbjct: 197 YRAPELIFGNQHYTTAVDIWSVGCIFAEMMLGE-PIFRGDNSAGQLHEIVRVLGCPSREV 255 Query: 288 PRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPA 347 R P P + S + E D ++ L P Sbjct: 256 LRKLNPSHTDVDLYNSKGIPWSNVF-----------SDHSLKDAKEAYDLLSALLQYLPE 304 Query: 348 ERADLKQLMVHAFIKRSD 365 ER + + H + Sbjct: 305 ERMKPYEALCHPYFDELH 322 >2I6L-A nrPDB Length = 320 Score = 208 bits (529), Expect = 4e-54, Method: Composition-based stats. Identities = 65/317 (20%), Positives = 125/317 (39%), Gaps = 39/317 (12%) Query: 67 DFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYI 126 + + LG G G+VF +A K I L P +RE++++ + I Sbjct: 12 RYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVL-TDPQSVKHALREIKIIRRLDHDNI 70 Query: 127 VGFY--------------GAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIA 172 V + G+ + I E+M+ L VL + G + E+ Sbjct: 71 VKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMET-DLANVL-EQGPLLEEHARLFMYQ 128 Query: 173 VIKGLTYLREKHKIMHRDVKPSNILVN-SRGEIKLCDFGVSGQLIDSMAN-----SFVGT 226 +++GL Y+ + ++HRD+KP+N+ +N +K+ DFG++ + ++ + T Sbjct: 129 LLRGLKYIHSAN-VLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVT 187 Query: 227 RSYMSPERLQG-THYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAE 285 + Y SP L +Y+ D+W+ G EM G+ E ++ + E Sbjct: 188 KWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELE-QMQLILESIPVVHE 246 Query: 286 TPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKN 345 + P+ + P + +LL I S E DF+ + L + Sbjct: 247 EDRQELLSVIPVYIRNDMTEPHKPLTQLLPGI-------------SREAVDFLEQILTFS 293 Query: 346 PAERADLKQLMVHAFIK 362 P +R ++ + H ++ Sbjct: 294 PMDRLTAEEALSHPYMS 310 >3HKO-A nrPDB Length = 345 Score = 207 bits (528), Expect = 5e-54, Method: Composition-based stats. Identities = 76/368 (20%), Positives = 128/368 (34%), Gaps = 98/368 (26%) Query: 51 EAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHL----EIKPA 106 E Q + EL + +G G+ GVV + + A K+++ +I P Sbjct: 12 ENLYFQGGSLLEL-QKKYHLKGAIGQGSYGVVRVAIENQTRAIRAIKIMNKNKIRQINPK 70 Query: 107 IRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLK---------- 156 +I E++++ + + P I Y + + I + ME GG L L Sbjct: 71 DVERIKTEVRLMKKLHHPNIARLYEVYEDEQYICLVMELCHGGHLLDKLNVFIDDSTGKC 130 Query: 157 -----KAGRIP-------------------------EQILGKVSIAVIKGLTYLREKHKI 186 K P E+++ + + L YL + I Sbjct: 131 AMDVVKTQICPCPECNEEAINGSIHGFRESLDFVQREKLISNIMRQIFSALHYLHNQ-GI 189 Query: 187 MHRDVKPSNILVNSR--GEIKLCDFGVSGQLID------SMANSFVGTRSYMSPERLQ-- 236 HRD+KP N L ++ EIKL DFG+S + + GT +++PE L Sbjct: 190 CHRDIKPENFLFSTNKSFEIKLVDFGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEVLNTT 249 Query: 237 GTHYSVQSDIWSMGLSLVEMAVGRYPIPP-PDAKELELMFGCQVEGDAAETPPRPRTPGR 295 Y + D WS G+ L + +G P P DA + + ++ Sbjct: 250 NESYGPKCDAWSAGVLLHLLLMGAVPFPGVNDADTISQVLNKKL---------------- 293 Query: 296 PLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQL 355 FE +Y V S +D ++ L +N ER D + Sbjct: 294 --------------CFENPNY-----------NVLSPLARDLLSNLLNRNVDERFDAMRA 328 Query: 356 MVHAFIKR 363 + H +I + Sbjct: 329 LQHPWISQ 336 >2VD5-A nrPDB Length = 412 Score = 207 bits (528), Expect = 5e-54, Method: Composition-based stats. Identities = 79/324 (24%), Positives = 120/324 (37%), Gaps = 57/324 (17%) Query: 54 LTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE--IKPAIRNQI 111 + + K L+ DDFE + +G G V V K +G V A K+++ +K + Sbjct: 49 IVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCF 108 Query: 112 IRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAG-RIPEQILGKVS 170 E VL + +I + AF + + + ME+ GG L +L K G RIP ++ Sbjct: 109 REERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYL 168 Query: 171 IAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLI-DSMANSF--VGTR 227 ++ + + + +HRD+KP NIL++ G I+L DFG +L D S VGT Sbjct: 169 AEIVMAIDSVH-RLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTP 227 Query: 228 SYMSPERLQ-------GTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVE 280 Y+SPE LQ Y + D W++G+ EM G+ P E Sbjct: 228 DYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETY-------- 279 Query: 281 GDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNK 340 G P L E +DF+ + Sbjct: 280 GKIVHYKEHLSLP-------------------------------LVDEGVPEEARDFIQR 308 Query: 341 CLIKNPAERA---DLKQLMVHAFI 361 L P R H F Sbjct: 309 LLCP-PETRLGRGGAGDFRTHPFF 331 >6BSD-A nrPDB Length = 876 Score = 207 bits (528), Expect = 5e-54, Method: Composition-based stats. Identities = 65/344 (18%), Positives = 115/344 (33%), Gaps = 80/344 (23%) Query: 62 ELKDDDFEKISELGAGNGGVVFKVS----------------HKPSGLVMARKLIHLEIKP 105 + +LG G G V K L++A K++ + Sbjct: 567 DFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATK 626 Query: 106 AIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAG------ 159 RN ++E++++ P I+ G D + + ++M+ G L+Q L Sbjct: 627 NARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAA 686 Query: 160 -------------RIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKL 206 I +L V+ + G+ YL + +HRD+ N LV IK+ Sbjct: 687 EGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLN-FVHRDLATRNCLVGENFTIKI 745 Query: 207 CDFGVSGQLIDSMANSFVGTR----SYMSPERLQGTHYSVQSDIWSMGLSLVE--MAVGR 260 DFG+S L G +M+ E + ++ SD+W+ G++L E M Sbjct: 746 ADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRA 805 Query: 261 YPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNE 320 P + QV +A E + + Sbjct: 806 QPFGQLTDE--------QVIENAGEF-----------------------FRDQGRQVYLS 834 Query: 321 PPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRS 364 PP P G++ + + +C + +R QL H F+ Sbjct: 835 RPPACPQGLY-----ELMLRCWSRESEQRPPFSQL--HRFLAED 871 >4OLI-A nrPDB Length = 645 Score = 207 bits (528), Expect = 5e-54, Method: Composition-based stats. Identities = 66/299 (22%), Positives = 118/299 (39%), Gaps = 41/299 (13%) Query: 68 FEKISELGAGNGGVVFKVSHKPS----GLVMARKLIHLEIKPAIRNQIIRELQVLHECNS 123 +KI +LG G+ G V + P+ G ++A K + + P R+ +E+ +L Sbjct: 355 LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYH 414 Query: 124 PYIVGFYGAFYSDGE--ISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLR 181 +I+ + G GE + + ME++ GSL L + I L + + +G+ YL Sbjct: 415 EHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHS-IGLAQLLLFAQQICEGMAYLH 473 Query: 182 EKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGT-----RSYMSPERLQ 236 +H I HR++ N+L+++ +K+ DFG++ + + V + +PE L+ Sbjct: 474 SQHYI-HRNLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLK 532 Query: 237 GTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRP 296 + SD+WS G++L E+ P K LEL+ Q + Sbjct: 533 EYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLT--------- 583 Query: 297 LSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQL 355 ELL+ P P E + C + R + L Sbjct: 584 ---------------ELLERGERLPRP----DKCPCEVYHLMKNCWETEASFRPTFENL 623 Score = 108 bits (270), Expect = 4e-24, Method: Composition-based stats. Identities = 50/235 (21%), Positives = 87/235 (37%), Gaps = 16/235 (6%) Query: 85 VSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICME 144 + L + K++ ++ + + ++ +G E + E Sbjct: 88 GRDRGQELRVVLKVLDPSHHDIA-LAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTE 146 Query: 145 HMDGGSLDQVLKK-AGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRG- 202 +++ G LD L++ G +P V+ + L+YL K+ ++H +V NIL+ G Sbjct: 147 YVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKN-LVHGNVCGRNILLARLGL 205 Query: 203 ------EIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQG--THYSVQSDIWSMGLSLV 254 IKL D GV L V +++PE L G S D W G +L+ Sbjct: 206 AEGTSPFIKLSDPGVG--LGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLL 263 Query: 255 EMAV-GRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPM 308 E+ G P+ E E + Q + P+ T +Y RP Sbjct: 264 EICFDGEAPLQSRSPSEKEHFYQRQHR-LPEPSCPQLATLTSQCLTYEPTQRPSF 317 >3BBT-B nrPDB Length = 328 Score = 207 bits (528), Expect = 5e-54, Method: Composition-based stats. Identities = 70/302 (23%), Positives = 129/302 (42%), Gaps = 30/302 (9%) Query: 63 LKDDDFEKISELGAGNGGVVFKVSHKPSGLVM----ARKLIHLEIKPAIRNQIIRELQVL 118 LK+ + +++ LG+G G V+K P G + A K+++ P + + E ++ Sbjct: 12 LKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIM 71 Query: 119 HECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKA-GRIPEQILGKVSIAVIKGL 177 + P++V G S I + + M G L + + + I Q+L + + KG+ Sbjct: 72 ASMDHPHLVRLLGVCLSPT-IQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGM 130 Query: 178 TYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLI-DSMANSFVGTR---SYMSPE 233 YL E+ +++HRD+ N+LV S +K+ DFG++ L D + G + +M+ E Sbjct: 131 MYLEER-RLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALE 189 Query: 234 RLQGTHYSVQSDIWSMGLSLVEMAV-GRYPIPPPDAKELELMFGCQVEGDAAETPPRPRT 292 + ++ QSD+WS G+++ E+ G P +E+ + +G+ PP Sbjct: 190 CIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLE---KGERLPQPPICTI 246 Query: 293 PGR----PLSSYGMDSRPPMAIFELLDYIVNEPPPK-----------LPSGVFSLEFQDF 337 DSRP + P + LPS S FQ+ Sbjct: 247 DVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNL 306 Query: 338 VN 339 ++ Sbjct: 307 LD 308 >4KIK-B nrPDB Length = 677 Score = 207 bits (528), Expect = 5e-54, Method: Composition-based stats. Identities = 66/297 (22%), Positives = 117/297 (39%), Gaps = 34/297 (11%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIV 127 +E LG G G V + ++ +G +A K E+ P R + E+Q++ P +V Sbjct: 21 WEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQIMRRLTHPNVV 80 Query: 128 GFYGAFYSDGEI------SICMEHMDGGSLDQVL---KKAGRIPEQILGKVSIAVIKGLT 178 + + ME+ GG L + L + + E + + + L Sbjct: 81 AARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALR 140 Query: 179 YLREKHKIMHRDVKPSNILVNSRGE---IKLCDFGVSGQLID-SMANSFVGTRSYMSPER 234 YL E ++I+HRD+KP NI++ + K+ D G + +L S+ SFVGT Y++PE Sbjct: 141 YLHE-NRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPEL 199 Query: 235 LQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPG 294 L+ Y+V D WS G E G P P + Sbjct: 200 LEQQKYTVTVDYWSFGTLAFECITGFRPFLP--------------------NWQPVQWHS 239 Query: 295 RPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERAD 351 + +D + + + + P P + V + + ++ L+ +P +R Sbjct: 240 KVRQKSEVDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGT 296 >5H2U-A nrPDB Length = 267 Score = 207 bits (527), Expect = 6e-54, Method: Composition-based stats. Identities = 66/257 (25%), Positives = 108/257 (42%), Gaps = 9/257 (3%) Query: 62 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHEC 121 E ++F +LG+G G VF+ K + +A K+I + + + E+Q + + Sbjct: 2 ERPREEFTLCRKLGSGYFGEVFEGLWK-DRVQVAIKVISRDNL-LHQQMLQSEIQAMKKL 59 Query: 122 NSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR--IPEQILGKVSIAVIKGLTY 179 +I+ Y + I E M GSL ++L+ + +P L ++ V +G+ Y Sbjct: 60 RHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCY 119 Query: 180 LREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTR--SYMSPERLQG 237 L ++ I HRD+ NILV K+ DFG++ + + + S + +PE L Sbjct: 120 LESQNYI-HRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEALSR 178 Query: 238 THYSVQSDIWSMGLSLVEMAV-GRYPIPPPDAKELELMFGCQVE-GDAAETPPRPRTPGR 295 HYS +SD+WS G+ L EM G+ P P E L E PP Sbjct: 179 GHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLML 238 Query: 296 PLSSYGMDSRPPMAIFE 312 + RP Sbjct: 239 TCWCRDPEQRPTFKALR 255 >4TPT-A nrPDB Length = 303 Score = 207 bits (526), Expect = 9e-54, Method: Composition-based stats. Identities = 67/273 (24%), Positives = 112/273 (41%), Gaps = 31/273 (11%) Query: 67 DFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYI 126 D LG G G KV+HK +G VM K + + + + E++V+ + P + Sbjct: 1 DLIHGEVLGKGFFGQAIKVTHKATGKVMVMKEL-IRCDEETQKTFLTEVKVMRSLDHPNV 59 Query: 127 VGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKI 186 + F G Y D ++++ E+++GG+L L+ P Q + + + G+ YL I Sbjct: 60 LKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMAYLHSMC-I 118 Query: 187 MHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA----------------------NSFV 224 +HRD+ N L+ + + DFG+S +++ + V Sbjct: 119 IHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVV 178 Query: 225 GTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQV----- 279 G +M+PE L G Y DI+S G+ L E+ G+ PD L FG V Sbjct: 179 GNPYWMAPEMLNGKSYDETVDIFSFGIVLCEII-GQV-YADPDCLPRTLDFGLNVKLFWE 236 Query: 280 EGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFE 312 + + PP +SRP + E Sbjct: 237 KFVPTDCPPAFFPLAAICCRLEPESRPAFSKLE 269 >6DBM-A nrPDB Length = 318 Score = 206 bits (525), Expect = 1e-53, Method: Composition-based stats. Identities = 68/300 (22%), Positives = 121/300 (40%), Gaps = 43/300 (14%) Query: 68 FEKISELGAGNGGVVFKVSHKPS----GLVMARKLIHLEIKPAIRNQIIRELQVLHECNS 123 +KI +LG G+ G V + P+ G ++A K + + P R+ +E+ +L Sbjct: 33 LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAGPQHRSGWKQEIDILRTLYH 92 Query: 124 PYIVGFYGAFYSDG--EISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLR 181 +I+ + G G + + ME++ GSL L + I L + + +G+ YL Sbjct: 93 EHIIKYKGCCEDAGAASLQLVMEYVPLGSLRDYLPRHS-IGLAQLLLFAQQICEGMAYLH 151 Query: 182 EKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGT-----RSYMSPERLQ 236 +H I HRD+ N+L+++ +K+ DFG++ + + V + +PE L+ Sbjct: 152 SQHYI-HRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLK 210 Query: 237 GTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRP 296 + SD+WS G++L E+ P K LEL+ Q + Sbjct: 211 EYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLT--------- 261 Query: 297 LSSYGMDSRPPMAIFELLDYIVNEP-PPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQL 355 ELL+ P P K P+ V+ + C + R + L Sbjct: 262 ---------------ELLERGERLPRPDKCPAEVY-----HLMKNCWETEASFRPTFENL 301 >4YHJ-A nrPDB Length = 584 Score = 206 bits (524), Expect = 1e-53, Method: Composition-based stats. Identities = 70/335 (20%), Positives = 127/335 (37%), Gaps = 59/335 (17%) Query: 46 QRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKP 105 Q K LE +Q V + + F LG G G V + +G + A K + + Sbjct: 173 QWKWLE-----RQPVTK---NTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIK 224 Query: 106 AIRNQI--IRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR--I 161 + + + E ++L + S ++V A+ + + + + M+GG L + G Sbjct: 225 KRKGEAMALNEKRILEKVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGF 284 Query: 162 PEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA- 220 EQ + + GL L ++ +I++RD+KP NIL++ RG I++ D G++ ++ + Sbjct: 285 DEQRAVFYAAELCCGLEDL-QRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRV 343 Query: 221 NSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVE 280 VGT YM+PE + Y+ D W +G + EM G P K Sbjct: 344 RGRVGTVGYMAPEVVNNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEK----------- 392 Query: 281 GDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNK 340 +E +D + + FS + + Sbjct: 393 ----------------------------VKWEEVDQRIKNDTEEYSEK-FSEDAKSICRM 423 Query: 341 CLIKNPAERA-----DLKQLMVHAFIKRSDAEEVD 370 L KNP++R + H K + ++ Sbjct: 424 LLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLE 458 >5UNP-A nrPDB Length = 369 Score = 206 bits (524), Expect = 1e-53, Method: Composition-based stats. Identities = 78/335 (23%), Positives = 129/335 (38%), Gaps = 29/335 (8%) Query: 60 VGELKDDDFEKISELGAGNGG-VVFKVSHKPSGLVMARKLIH--LEIKPAIRNQI-IREL 115 VG+ + +E +S LG G G VV V H+ G +A K+I + K A R +I + E Sbjct: 28 VGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEK 87 Query: 116 QVLHECNSPY-IVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQI--LGKVSIA 172 + ++ V + F G + I E + G S LK +P I + ++ Sbjct: 88 INEKDPDNKNLCVQMFDWFDYHGHMCISFELL-GLSTFDFLKDNNYLPYPIHQVRHMAFQ 146 Query: 173 VIKGLTYLREKHKIMHRDVKPSNIL-VNSRGE------------------IKLCDFGVSG 213 + + + +L + +K+ H D+KP NIL VNS E +++ DFG + Sbjct: 147 LCQAVKFLHD-NKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSAT 205 Query: 214 QLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELEL 273 ++ V TR Y +PE + +S D+WS+G + E VG D +E Sbjct: 206 -FDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLA 264 Query: 274 MFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLE 333 M + + + R A + + + Sbjct: 265 MMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQ 324 Query: 334 FQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEE 368 D + L PA+R L + + H F R AE Sbjct: 325 LFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEP 359 >3GQL-A nrPDB Length = 326 Score = 206 bits (523), Expect = 2e-53, Method: Composition-based stats. Identities = 70/311 (22%), Positives = 120/311 (38%), Gaps = 36/311 (11%) Query: 56 QKQKVGELKDDDFEKISELGAGNGGVVFKV------SHKPSGL-VMARKLIHLEIKPAIR 108 + EL D LG G G V KP+ + +A K++ + Sbjct: 18 PEDPRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDL 77 Query: 109 NQIIRELQVLHEC-NSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR------- 160 + +I E++++ I+ GA DG + + +E+ G+L + L+ Sbjct: 78 SDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCY 137 Query: 161 ---------IPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGV 211 + + L + V +G+ YL K K +HRD+ N+LV +K+ DFG+ Sbjct: 138 NPSHNPEEQLSSKDLVSCAYQVARGMEYLASK-KCIHRDLAARNVLVTEDNVMKIADFGL 196 Query: 212 SGQL--IDSMANSFVGTR--SYMSPERLQGTHYSVQSDIWSMGLSLVEMAV-GRYPIPPP 266 + + ID + G +M+PE L Y+ QSD+WS G+ L E+ G P P Sbjct: 197 ARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGV 256 Query: 267 DAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLP 326 +EL F EG + P L D + + E ++ Sbjct: 257 PVEEL---FKLLKEGHRMDKP---SNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIV 310 Query: 327 SGVFSLEFQDF 337 + + E+ D Sbjct: 311 ALTSNQEYLDL 321 >6CTH-A nrPDB Length = 309 Score = 205 bits (522), Expect = 2e-53, Method: Composition-based stats. Identities = 61/220 (27%), Positives = 106/220 (48%), Gaps = 7/220 (3%) Query: 67 DFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYI 126 +F ++LG G G V++ + S +A K + K I+ + E++++ + Sbjct: 16 NFNAENKLGEGGFGSVYRGFLRDSDTYIAVKKVSRASKQGIK-EYASEVKIISRLRHKNL 74 Query: 127 VGFYGAFYSDGEISICMEHMDGGSLDQVL-KKAGRIPEQILGKVSIAVIKGLTYLREK-- 183 V G + GE+ + E M GSLD + K + ++ ++ + L YL E+ Sbjct: 75 VKLIGWCHERGELMLVYEFMANGSLDSHIFKGKSLLTWEVRYRIVKDLASALLYLHEEGD 134 Query: 184 HKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSM---ANSFVGTRSYMSPERLQGTHY 240 H ++HRD+K SNI+++S KL DFG++ + + GT YM+PE L Sbjct: 135 HCVLHRDIKTSNIMLDSSFNAKLGDFGLARLVDHAKGLKKTLLAGTVGYMAPECLSSGKA 194 Query: 241 SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVE 280 S +SD++S G+ +E+A GR I P + L+ V Sbjct: 195 SKESDVYSFGVVALEIASGRRSIEPKFEESEALLLVPWVW 234 >6GQK-A nrPDB Length = 328 Score = 205 bits (522), Expect = 2e-53, Method: Composition-based stats. Identities = 64/279 (22%), Positives = 106/279 (37%), Gaps = 30/279 (10%) Query: 61 GELKDDDFEKISELGAGNGGVVFKVS-----HKPSGLVMARKLIHLEIKPAIRNQIIREL 115 E + LGAG G V + + + + +A K++ R ++ EL Sbjct: 36 WEFPRNRLSFGKTLGAGAFGKVVEATAQGLIKSDAAMTVAVKMLKPSAHSTEREALMSEL 95 Query: 116 QVLHEC-NSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKA---------------- 158 +VL N IV GA G + E+ G L L++ Sbjct: 96 KVLSYLGNHENIVNLLGACTHGGPTLVITEYCCYGDLLNFLRRKRDEFVPYKVAPEDLYK 155 Query: 159 GRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS 218 + + L S V KG+ +L K+ +HRD+ NIL+ K+CDFG++ + + Sbjct: 156 DFLTLEHLLSFSYQVAKGMAFLASKN-CIHRDLAARNILLTHGNITKICDFGLARDIKND 214 Query: 219 MANSFVGTRS----YMSPERLQGTHYSVQSDIWSMGLSLVEMAV-GRYPIP--PPDAKEL 271 G +M+PE + + Y+ +SD+WS G+ L E+ G P P P D+K Sbjct: 215 SNYVDKGNARLPVKWMAPESIFNSVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFY 274 Query: 272 ELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAI 310 +++ P + D RP Sbjct: 275 KMIKEGFRMSSPEYAPAEMYDIMKTCWDADPDKRPTFKQ 313 >2VWV-A nrPDB Length = 302 Score = 205 bits (522), Expect = 2e-53, Method: Composition-based stats. Identities = 61/271 (22%), Positives = 102/271 (37%), Gaps = 14/271 (5%) Query: 69 EKISELGAGNGGVVFKVSHKPSGLV---MARKLIHLEIKPAIRNQIIRELQVLHECNSPY 125 + +GAG G V + K G +A K + R + + E ++ + P Sbjct: 19 KIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLSEASIMGQFEHPN 78 Query: 126 IVGFYGAFYSDGEISICMEHMDGGSLDQVLK-KAGRIPEQILGKVSIAVIKGLTYLREKH 184 I+ G + + I E M+ G+LD L+ G+ L + + G+ YL E Sbjct: 79 IIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGMRYLAEMS 138 Query: 185 KIMHRDVKPSNILVNSRGEIKLCDFGVSGQL----IDSMANSFVGTR---SYMSPERLQG 237 + HRD+ NILVNS K+ DFG+S L D S +G + + +PE + Sbjct: 139 YV-HRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTETSSLGGKIPIRWTAPEAIAF 197 Query: 238 THYSVQSDIWSMGLSLVE-MAVGRYPIPPPDAKELELMFGCQVE-GDAAETPPRPRTPGR 295 ++ SD WS G+ + E M+ G P +++ + P Sbjct: 198 RKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCPTSLHQLML 257 Query: 296 PLSSYGMDSRPPMAIFELLDYIVNEPPPKLP 326 ++RP + P L Sbjct: 258 DCWQKDRNARPRFPQVVSALDKMIRNPASLK 288 >3TT0-A nrPDB Length = 382 Score = 205 bits (522), Expect = 2e-53, Method: Composition-based stats. Identities = 72/331 (21%), Positives = 119/331 (35%), Gaps = 73/331 (22%) Query: 56 QKQKVGELKDDDFEKISELGAGNGGVVFKV------SHKPSGL-VMARKLIHLEIKPAIR 108 + EL D LG G G V KP+ + +A K++ + Sbjct: 59 PEDPRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDL 118 Query: 109 NQIIRELQVLHEC-NSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR------- 160 + +I E++++ I+ GA DG + + +E+ G+L + L+ Sbjct: 119 SDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYSY 178 Query: 161 ---------IPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGV 211 + + L + V +G+ YL K K +HRD+ N+LV +K+ DFG+ Sbjct: 179 NPSHNPEEQLSSKDLVSCAYQVARGMEYLASK-KCIHRDLAARNVLVTEDNVMKIADFGL 237 Query: 212 SGQL--IDSMANSFVGTR--SYMSPERLQGTHYSVQSDIWSMGLSLVEMAV-GRYPIPPP 266 + + ID + G +M+PE L Y+ QSD+WS G+ L E+ G P P Sbjct: 238 ARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGV 297 Query: 267 DAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLP 326 +EL F EG + P Sbjct: 298 PVEEL---FKLLKEGHRMDKPSNCTN---------------------------------- 320 Query: 327 SGVFSLEFQDFVNKCLIKNPAERADLKQLMV 357 E + C P++R KQL+ Sbjct: 321 ------ELYMMMRDCWHAVPSQRPTFKQLVE 345 >3BEA-A nrPDB Length = 333 Score = 205 bits (522), Expect = 3e-53, Method: Composition-based stats. Identities = 61/279 (21%), Positives = 111/279 (39%), Gaps = 28/279 (10%) Query: 59 KVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLV-----MARKLIHLEIKPAIRNQIIR 113 + E ++ + LGAG G V + + G +A K++ + ++ Sbjct: 39 EKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMS 98 Query: 114 ELQVLHEC-NSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR------------ 160 EL+++ IV GA G + + E+ G L L++ R Sbjct: 99 ELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKSRVLETDPAFAIAN 158 Query: 161 --IPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS 218 + + L S V +G+ +L K+ +HRDV N+L+ + K+ DFG++ +++ Sbjct: 159 STLSTRDLLHFSSQVAQGMAFLASKN-CIHRDVAARNVLLTNGHVAKIGDFGLARDIMND 217 Query: 219 MANSFVGTRS----YMSPERLQGTHYSVQSDIWSMGLSLVEMAV-GRYPIPPP--DAKEL 271 G +M+PE + Y+VQSD+WS G+ L E+ G P P ++K Sbjct: 218 SNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFY 277 Query: 272 ELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAI 310 +L+ A P + + + RP Sbjct: 278 KLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQ 316 >4OTD-A nrPDB Length = 341 Score = 205 bits (521), Expect = 3e-53, Method: Composition-based stats. Identities = 74/312 (23%), Positives = 124/312 (39%), Gaps = 58/312 (18%) Query: 63 LKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE--IKPAIRNQIIRELQVLHE 120 L +DF+ ++ LG G+ G V +PSG + A K + + ++ E ++L Sbjct: 9 LTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAA 68 Query: 121 CN---SPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGL 177 P++V +G F + + ME+ GG L + E S V+ GL Sbjct: 69 VTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHS-DVFSEPRAIFYSACVVLGL 127 Query: 178 TYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL--IDSMANSFVGTRSYMSPERL 235 +L E HKI++RD+K N+L+++ G +K+ DFG+ + ++F GT +++PE L Sbjct: 128 QFLHE-HKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVL 186 Query: 236 QGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGR 295 T Y+ D W +G+ L EM VG P P D +E+ + D P Sbjct: 187 TDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEV----FDSIVNDEVRYPRF------ 236 Query: 296 PLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERA----- 350 S E + + L +NP R Sbjct: 237 ----------------------------------LSAEAIGIMRRLLRRNPERRLGSSER 262 Query: 351 DLKQLMVHAFIK 362 D + + F + Sbjct: 263 DAEDVKKQPFFR 274 >5A46-A nrPDB Length = 386 Score = 205 bits (521), Expect = 3e-53, Method: Composition-based stats. Identities = 71/321 (22%), Positives = 123/321 (38%), Gaps = 36/321 (11%) Query: 56 QKQKVGELKDDDFEKISELGAGNGGVVFKV------SHKPSGL-VMARKLIHLEIKPAIR 108 + EL D LG G G V KP+ + +A K++ + Sbjct: 30 PEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDL 89 Query: 109 NQIIRELQVLHEC-NSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR------- 160 + +I E++++ I+ GA DG + + +E+ G+L + L+ Sbjct: 90 SDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCY 149 Query: 161 ---------IPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGV 211 + + L + V +G+ YL K K +HRD+ N+LV +K+ DFG+ Sbjct: 150 NPSHNPEEQLSSKDLVSCAYQVARGMEYLASK-KCIHRDLAARNVLVTEDNVMKIADFGL 208 Query: 212 SGQL--IDSMANSFVGTR--SYMSPERLQGTHYSVQSDIWSMGLSLVEMAV-GRYPIPPP 266 + + ID + G +M+PE L Y+ QSD+WS G+ L E+ G P P Sbjct: 209 ARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGV 268 Query: 267 DAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLP 326 +EL F EG + P L D + + E ++ Sbjct: 269 PVEEL---FKLLKEGHRMDKP---SNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIV 322 Query: 327 SGVFSLEFQDFVNKCLIKNPA 347 + + E+ D +P+ Sbjct: 323 ALTSNQEYLDLSMPLDQYSPS 343 >3PG1-A nrPDB Length = 362 Score = 205 bits (521), Expect = 3e-53, Method: Composition-based stats. Identities = 64/337 (18%), Positives = 121/337 (35%), Gaps = 34/337 (10%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIR----------NQIIRELQV 117 + + +G+ G V G+ +A K + + +++RE+++ Sbjct: 24 YTVQRFISSGSYGAVCAGVD-SEGIPVAIKRVFNTVSDGRTVNILSDSFLCKRVLREIRL 82 Query: 118 LHECNSPYIVGFYGAFYSDGE-----ISICMEHMDGGSLDQVLK-KAGRIPEQILGKVSI 171 L+ + P I+G F E + + E M L QV+ + I Q + Sbjct: 83 LNHFHHPNILGLRDIFVHFEEPAMHKLYLVTELMRT-DLAQVIHDQRIVISPQHIQYFMY 141 Query: 172 AVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQ-LIDSMANSFVGTRSYM 230 ++ GL L E ++HRD+ P NIL+ +I +CDF ++ + D+ +V R Y Sbjct: 142 HILLGLHVLHEA-GVVHRDLHPGNILLADNNDITICDFNLAREDTADANKTHYVTHRWYR 200 Query: 231 SPE-RLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPR 289 +PE +Q ++ D+WS G + EM + + + + Sbjct: 201 APELVMQFKGFTKLVDMWSAGCVMAEMFNRKALFRG--STFYNQLNKIVEVVGTPKIEDV 258 Query: 290 PRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAER 349 Y +S + + P L D + K L NP R Sbjct: 259 VMFSSPSARDYLRNSLSNVPARAWTAVVPTADPVAL----------DLIAKMLEFNPQRR 308 Query: 350 ADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQPST 386 +Q + H + + + +D L ++ T Sbjct: 309 ISTEQALRHPYFESL-FDPLDLTEGLSERFHFDESVT 344 >5AMN-A nrPDB Length = 299 Score = 205 bits (521), Expect = 3e-53, Method: Composition-based stats. Identities = 70/282 (24%), Positives = 113/282 (40%), Gaps = 24/282 (8%) Query: 45 QQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKV-----SHKPSGLVMARKLI 99 ++AF + E + LG G G V K + +A K++ Sbjct: 2 PLSLSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKML 61 Query: 100 HLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAG 159 P+ ++ E VL + N P+++ YGA DG + + +E+ GSL L+++ Sbjct: 62 KENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESR 121 Query: 160 R----------IPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDF 209 + + L + + +G+ YL E K++HRD+ NILV ++K+ DF Sbjct: 122 KVGPGYPDERALTMGDLISFAWQISQGMQYLAEM-KLVHRDLAARNILVAEGRKMKISDF 180 Query: 210 GVSGQLI--DSMANSFVGTR--SYMSPERLQGTHYSVQSDIWSMGLSLVEMAV-GRYPIP 264 G+S + DS G +M+ E L Y+ QSD+WS G+ L E+ G P P Sbjct: 181 GLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYP 240 Query: 265 PPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRP 306 E +F G E P L P Sbjct: 241 GIPP---ERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEP 279 >3PP0-A nrPDB Length = 338 Score = 205 bits (521), Expect = 3e-53, Method: Composition-based stats. Identities = 67/277 (24%), Positives = 119/277 (42%), Gaps = 19/277 (6%) Query: 63 LKDDDFEKISELGAGNGGVVFKVSHKPSGL----VMARKLIHLEIKPAIRNQIIRELQVL 118 LK+ + K+ LG+G G V+K P G +A K++ P +I+ E V+ Sbjct: 14 LKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVM 73 Query: 119 HECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKK-AGRIPEQILGKVSIAVIKGL 177 SPY+ G + + + + M G L +++ GR+ Q L + + KG+ Sbjct: 74 AGVGSPYVSRLLGICLTST-VQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGM 132 Query: 178 TYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL-IDSMANSFVGTR---SYMSPE 233 +YL E +++HRD+ N+LV S +K+ DFG++ L ID G + +M+ E Sbjct: 133 SYL-EDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALE 191 Query: 234 RLQGTHYSVQSDIWSMGLSLVEMAV-GRYPIPPPDAKELELMFGCQVEGDAAETPPRPRT 292 + ++ QSD+WS G+++ E+ G P A+E+ + +G+ PP Sbjct: 192 SILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLE---KGERLPQPPICTI 248 Query: 293 PGR----PLSSYGMDSRPPMAIFELLDYIVNEPPPKL 325 + RP + P + Sbjct: 249 DVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRF 285 >3IO7-A nrPDB Length = 313 Score = 205 bits (521), Expect = 3e-53, Method: Composition-based stats. Identities = 76/311 (24%), Positives = 126/311 (40%), Gaps = 41/311 (13%) Query: 57 KQKVGELKDDDFEKISELGAGNGGVVFKVSHKP----SGLVMARKLIHLEIKPAIRNQII 112 + + ++ + + +LG GN G V + P +G V+A K + + +R+ Sbjct: 19 SHNMTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRD-FE 77 Query: 113 RELQVLHECNSPYIVGFYGAFYSDGE--ISICMEHMDGGSLDQVLKKAG-RIPEQILGKV 169 RE+++L IV + G YS G + + ME++ GSL L+K RI L + Sbjct: 78 REIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQY 137 Query: 170 SIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRS- 228 + + KG+ YL K I HRD+ NILV + +K+ DFG++ L V Sbjct: 138 TSQICKGMEYLGTKRYI-HRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGE 196 Query: 229 ----YMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAA 284 + +PE L + +SV SD+WS G+ L E+ Sbjct: 197 SPIFWYAPESLTESKFSVASDVWSFGVVLYELFT-------------------------- 230 Query: 285 ETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIK 344 P + G D + M +F L++ + N P G E + +C Sbjct: 231 YIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGC-PDEIYMIMTECWNN 289 Query: 345 NPAERADLKQL 355 N +R + L Sbjct: 290 NVNQRPSFRDL 300 >2OGV-A nrPDB Length = 317 Score = 205 bits (521), Expect = 3e-53, Method: Composition-based stats. Identities = 60/275 (21%), Positives = 110/275 (40%), Gaps = 24/275 (8%) Query: 59 KVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLV-----MARKLIHLEIKPAIRNQIIR 113 + E ++ + LGAG G V + + G +A K++ + ++ Sbjct: 31 EKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMS 90 Query: 114 ELQVLHEC-NSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKA----------GRIP 162 EL+++ IV GA G + + E+ G L L++ + Sbjct: 91 ELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEADLDKEDGRPLE 150 Query: 163 EQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANS 222 + L S V +G+ +L K+ +HRDV N+L+ + K+ DFG++ +++ Sbjct: 151 LRDLLHFSSQVAQGMAFLASKN-CIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYI 209 Query: 223 FVGTRS----YMSPERLQGTHYSVQSDIWSMGLSLVEMAV-GRYPIPPP--DAKELELMF 275 G +M+PE + Y+VQSD+WS G+ L E+ G P P ++K +L+ Sbjct: 210 VKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVK 269 Query: 276 GCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAI 310 A P + + + RP Sbjct: 270 DGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQ 304 >4CRS-A nrPDB Length = 341 Score = 204 bits (520), Expect = 4e-53, Method: Composition-based stats. Identities = 71/323 (21%), Positives = 124/323 (38%), Gaps = 58/323 (17%) Query: 55 TQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE--IKPAIRNQII 112 + Q+ + DF + L G+ G V +K + + A K + + + ++ Sbjct: 1 SMSQQRFQFNLQDFRCCAVLLRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLM 60 Query: 113 RELQVLHECN---SPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKV 169 E ++ N P++V + F + + ME+ GG L + E Sbjct: 61 CEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIH-TDVFSEPRAVFY 119 Query: 170 SIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL--IDSMANSFVGTR 227 + V+ GL YL E HKI++RD+K N+L+++ G +K+ DFG+ + ++F GT Sbjct: 120 AACVVLGLQYLHE-HKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTP 178 Query: 228 SYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETP 287 +++PE L T Y+ D W +G+ + EM VG P P D +E+ + D P Sbjct: 179 EFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEV----FDSIVNDEVRYP 234 Query: 288 PRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPA 347 S E + + L +NP Sbjct: 235 RF----------------------------------------LSTEAISIMRRLLRRNPE 254 Query: 348 ERA-----DLKQLMVHAFIKRSD 365 R D + + H F + D Sbjct: 255 RRLGASEKDAEDVKKHPFFRLID 277 >2W1I-A nrPDB Length = 326 Score = 204 bits (520), Expect = 4e-53, Method: Composition-based stats. Identities = 76/306 (24%), Positives = 125/306 (40%), Gaps = 41/306 (13%) Query: 62 ELKDDDFEKISELGAGNGGVVFKVSHKP----SGLVMARKLIHLEIKPAIRNQIIRELQV 117 + ++ + + +LG GN G V + P +G V+A K + + +R+ RE+++ Sbjct: 37 QFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRD-FEREIEI 95 Query: 118 LHECNSPYIVGFYGAFYSDGE--ISICMEHMDGGSLDQVLKKAG-RIPEQILGKVSIAVI 174 L IV + G YS G + + ME++ GSL L+K RI L + + + Sbjct: 96 LKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQIC 155 Query: 175 KGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRS-----Y 229 KG+ YL K I HRD+ NILV + +K+ DFG++ L V + Sbjct: 156 KGMEYLGTKRYI-HRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFW 214 Query: 230 MSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPR 289 +PE L + +SV SD+WS G+ L E+ Sbjct: 215 YAPESLTESKFSVASDVWSFGVVLYELFT--------------------------YIEKS 248 Query: 290 PRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAER 349 P + G D + M +F L++ + N P G E + +C N +R Sbjct: 249 KSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGC-PDEIYMIMTECWNNNVNQR 307 Query: 350 ADLKQL 355 + L Sbjct: 308 PSFRDL 313 >3QA8-A nrPDB Length = 676 Score = 204 bits (519), Expect = 6e-53, Method: Composition-based stats. Identities = 60/211 (28%), Positives = 97/211 (45%), Gaps = 14/211 (6%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIV 127 +E LG G G V + H+ +G +A K E+ P R + E+Q++ + N P +V Sbjct: 16 WEMKERLGTGGFGYVLRWIHQDTGEQVAIKQCRQELSPKNRERWCLEIQIMKKLNHPNVV 75 Query: 128 GFYGAFYSDGEI------SICMEHMDGGSLDQVL---KKAGRIPEQILGKVSIAVIKGLT 178 ++ + ME+ +GG L + L + + E + + + L Sbjct: 76 SAREVPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGPIRTLLSDISSALR 135 Query: 179 YLREKHKIMHRDVKPSNILVN---SRGEIKLCDFGVSGQLID-SMANSFVGTRSYMSPER 234 YL E ++I+HRD+KP NI++ R K+ D G + +L + FVGT Y++PE Sbjct: 136 YLHE-NRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQGELCTEFVGTLQYLAPEL 194 Query: 235 LQGTHYSVQSDIWSMGLSLVEMAVGRYPIPP 265 L+ Y+V D WS G E G P P Sbjct: 195 LEQKKYTVTVDYWSFGTLAFECITGFRPFLP 225 >2PL0-A nrPDB Length = 289 Score = 204 bits (518), Expect = 7e-53, Method: Composition-based stats. Identities = 56/255 (21%), Positives = 109/255 (42%), Gaps = 12/255 (4%) Query: 61 GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE 120 E+ + + + LGAG G V+ + +A K + + + E ++ + Sbjct: 18 WEVPRETLKLVERLGAGQFGEVWMGYYNGHTK-VAVKSLKQ--GSMSPDAFLAEANLMKQ 74 Query: 121 CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAG--RIPEQILGKVSIAVIKGLT 178 +V Y + I I E+M+ GSL LK ++ L ++ + +G+ Sbjct: 75 LQHQRLVRLYAVVTQE-PIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMA 133 Query: 179 YLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTR---SYMSPERL 235 ++ E++ I HRD++ +NILV+ K+ DFG++ + D+ + G + + +PE + Sbjct: 134 FIEERNYI-HRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAI 192 Query: 236 QGTHYSVQSDIWSMGLSLVEMAV-GRYPIPPPDAKE-LELMFGCQVEGDAAETPPRPRTP 293 ++++SD+WS G+ L E+ GR P P E ++ + P Sbjct: 193 NYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQL 252 Query: 294 GRPLSSYGMDSRPPM 308 R + RP Sbjct: 253 MRLCWKERPEDRPTF 267 >3KRL-A nrPDB Length = 335 Score = 204 bits (518), Expect = 7e-53, Method: Composition-based stats. Identities = 60/281 (21%), Positives = 110/281 (39%), Gaps = 30/281 (10%) Query: 59 KVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLV-----MARKLIHLEIKPAIRNQIIR 113 + E ++ + LGAG G V + + G +A K++ + ++ Sbjct: 39 EKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMS 98 Query: 114 ELQVLHEC-NSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR------------ 160 EL+++ IV GA G + + E+ G L L++ Sbjct: 99 ELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKRPPGLEYSYNPSHN 158 Query: 161 ----IPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLI 216 + + L S V +G+ +L K+ +HRDV N+L+ + K+ DFG++ ++ Sbjct: 159 PEEQLSSRDLLHFSSQVAQGMAFLASKN-CIHRDVAARNVLLTNGHVAKIGDFGLARDIM 217 Query: 217 DSMANSFVGTRS----YMSPERLQGTHYSVQSDIWSMGLSLVEMAV-GRYPIPPP--DAK 269 + G +M+PE + Y+VQSD+WS G+ L E+ G P P ++K Sbjct: 218 NDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSK 277 Query: 270 ELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAI 310 +L+ A P + + + RP Sbjct: 278 FYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQ 318 >1LUF-A nrPDB Length = 343 Score = 203 bits (517), Expect = 9e-53, Method: Composition-based stats. Identities = 63/302 (20%), Positives = 112/302 (37%), Gaps = 40/302 (13%) Query: 44 EQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGL-------VMAR 96 +R+ L K E ++ E + ++G G G VF+ + GL ++A Sbjct: 25 NPMYQRMPLLLNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQA--RAPGLLPYEPFTMVAV 82 Query: 97 KLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLK 156 K++ E ++ RE ++ E ++P IV G + + E+M G L++ L+ Sbjct: 83 KMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLR 142 Query: 157 KAG------------------------RIPEQILGKVSIAVIKGLTYLREKHKIMHRDVK 192 + ++ V G+ YL E+ K +HRD+ Sbjct: 143 SMSPHTVCSLSHSDLSTRARVSSPGPPPLSCAEQLCIARQVAAGMAYLSER-KFVHRDLA 201 Query: 193 PSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGT----RSYMSPERLQGTHYSVQSDIWS 248 N LV +K+ DFG+S + + G +M PE + Y+ +SD+W+ Sbjct: 202 TRNCLVGENMVVKIADFGLSRNIYSADYYKADGNDAIPIRWMPPESIFYNRYTTESDVWA 261 Query: 249 MGLSLVEMA-VGRYPIPPPDAKE-LELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRP 306 G+ L E+ G P +E + + + P R S RP Sbjct: 262 YGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILACPENCPLELYNLMRLCWSKLPADRP 321 Query: 307 PM 308 Sbjct: 322 SF 323 >4XLV-A nrPDB Length = 328 Score = 203 bits (516), Expect = 1e-52, Method: Composition-based stats. Identities = 59/327 (18%), Positives = 108/327 (33%), Gaps = 70/327 (21%) Query: 61 GELKDDDFEKISELGAGNGGVVFK--VSHKPSGLV---MARKLIHLEIKPAIRNQIIREL 115 E+ + + ELG G+ G+V++ G +A K ++ R + + E Sbjct: 34 WEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEA 93 Query: 116 QVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPE----------QI 165 V+ ++V G + ME M G L L+ E Q Sbjct: 94 SVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQE 153 Query: 166 LGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVG 225 + +++ + G+ YL K K +HRD+ N +V +K+ DFG++ + ++ G Sbjct: 154 MIQMAAEIADGMAYLNAK-KFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGG 212 Query: 226 ----TRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAV-GRYPIPPPDAKELELMFGCQVE 280 +M+PE L+ ++ SD+WS G+ L E+ P E + ++ Sbjct: 213 KGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSN---EQVLKFVMD 269 Query: 281 GDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNK 340 G + P D + Sbjct: 270 GGYLDQPDNC----------------------------------------PERVTDLMRM 289 Query: 341 CLIKNPAERADLKQLMV------HAFI 361 C NP R +++ H Sbjct: 290 CWQFNPNMRPTFLEIVNLLKDDLHPSF 316 >1U59-A nrPDB Length = 287 Score = 203 bits (516), Expect = 1e-52, Method: Composition-based stats. Identities = 70/261 (26%), Positives = 120/261 (45%), Gaps = 13/261 (4%) Query: 63 LKDDDFEKIS-ELGAGNGGVVFKV--SHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLH 119 LK D+ ELG GN G V + + + +A K++ + A +++RE Q++H Sbjct: 6 LKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMH 65 Query: 120 ECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLK-KAGRIPEQILGKVSIAVIKGLT 178 + ++PYIV G ++ + + ME GG L + L K IP + ++ V G+ Sbjct: 66 QLDNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMK 124 Query: 179 YLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL--IDSMANSFVGTRS---YMSPE 233 YL EK+ +HRD+ N+L+ +R K+ DFG+S L DS + + + +PE Sbjct: 125 YLEEKN-FVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPE 183 Query: 234 RLQGTHYSVQSDIWSMGLSLVE-MAVGRYPIPPPDAKELELMFG-CQVEGDAAETPPRPR 291 + +S +SD+WS G+++ E ++ G+ P E+ + E PP Sbjct: 184 CINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELY 243 Query: 292 TPGRPLSSYGMDSRPPMAIFE 312 Y + RP E Sbjct: 244 ALMSDCWIYKWEDRPDFLTVE 264 >4E20-A nrPDB Length = 290 Score = 202 bits (515), Expect = 2e-52, Method: Composition-based stats. Identities = 62/269 (23%), Positives = 111/269 (41%), Gaps = 22/269 (8%) Query: 68 FEKISELGAGNGGVVFKVSHKPS----GLVMARKLIHLEIKPAIRNQIIRELQVLHECNS 123 +KI +LG G+ G V + P+ G ++A K + P +R+ RE+++L Sbjct: 10 LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSGWQREIEILRTLYH 69 Query: 124 PYIVGFYGAFYSDGE--ISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLR 181 +IV + G GE + + ME++ GSL L + + L + + +G+ YL Sbjct: 70 EHIVKYKGCCEDQGEKSVQLVMEYVPLGSLRDYLPRHC-VGLAQLLLFAQQICEGMAYLH 128 Query: 182 EKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGT-----RSYMSPERLQ 236 +H I HR + N+L+++ +K+ DFG++ + + V + +PE L+ Sbjct: 129 AQHYI-HRALAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLK 187 Query: 237 GTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELM---------FGCQVEGDAAETP 287 + SD+WS G++L E+ P K EL+ + E Sbjct: 188 ECKFYYASDVWSFGVTLYELLTYCDSNQSPHTKFTELIGHTQGQMTVLRLTELLERGERL 247 Query: 288 PRPRTPGRPLSSYGMDSRPPMAIFELLDY 316 PRP + + A F Sbjct: 248 PRPDRCPCEIYHLMKNCWETEASFRPTFQ 276 >3M42-A nrPDB Length = 299 Score = 202 bits (514), Expect = 2e-52, Method: Composition-based stats. Identities = 72/335 (21%), Positives = 120/335 (35%), Gaps = 82/335 (24%) Query: 66 DDFEKI-SELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSP 124 DD++ LG G G V ++ +K + A K++ + P R ++ + + Sbjct: 17 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML--QDCPKARREVELHWRASQCPHIV 74 Query: 125 YIVGFYGAFYSDGE-ISICMEHMDGGSLDQVLKKAGR--IPEQILGKVSIAVIKGLTYLR 181 IV Y Y+ + + I ME +DGG L ++ G E+ ++ ++ + + YL Sbjct: 75 RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 134 Query: 182 EKHKIMHRDVKPSNILVNS---RGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGT 238 + I HRDVKP N+L S +KL DFG + + G Sbjct: 135 SIN-IAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT--------------------GE 173 Query: 239 HYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLS 298 Y D+WS+G+ + + G P + Sbjct: 174 KYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAI--------------------------- 206 Query: 299 SYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVH 358 S GM +R M +E P P+ S E + + L P +R + + M H Sbjct: 207 SPGMKTRIRMGQYEF-------PNPEWSE--VSEEVKMLIRNLLKTEPTQRMTITEFMNH 257 Query: 359 AFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV 393 +I +S P TP H + V Sbjct: 258 PWIMQST----------------KVPQTPLHTSRV 276 >1K9A-A nrPDB Length = 450 Score = 202 bits (514), Expect = 2e-52, Method: Composition-based stats. Identities = 62/257 (24%), Positives = 107/257 (41%), Gaps = 12/257 (4%) Query: 61 GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE 120 L + + + +G G G V ++ G +A K I + + E V+ + Sbjct: 188 WALNMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATA---QAFLAEASVMTQ 242 Query: 121 CNSPYIVGFYGAF-YSDGEISICMEHMDGGSLDQVLKKAGR--IPEQILGKVSIAVIKGL 177 +V G G + I E+M GSL L+ GR + L K S+ V + + Sbjct: 243 LRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAM 302 Query: 178 TYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQG 237 YL E + +HRD+ N+LV+ K+ DFG++ + + + + +PE L+ Sbjct: 303 EYL-EGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKL-PVKWTAPEALRE 360 Query: 238 THYSVQSDIWSMGLSLVEM-AVGRYPIPPPDAKELELMFGCQVEGDAAE-TPPRPRTPGR 295 +S +SD+WS G+ L E+ + GR P P K++ + DA + PP + Sbjct: 361 KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMK 420 Query: 296 PLSSYGMDSRPPMAIFE 312 +RP Sbjct: 421 NCWHLDAATRPTFLQLR 437 >1BYG-A nrPDB Length = 278 Score = 202 bits (514), Expect = 2e-52, Method: Composition-based stats. Identities = 62/257 (24%), Positives = 106/257 (41%), Gaps = 12/257 (4%) Query: 61 GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE 120 L + + + +G G G V ++ G +A K I + + E V+ + Sbjct: 16 WALNMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATA---QAFLAEASVMTQ 70 Query: 121 CNSPYIVGFYGAF-YSDGEISICMEHMDGGSLDQVLKKAGR--IPEQILGKVSIAVIKGL 177 +V G G + I E+M GSL L+ GR + L K S+ V + + Sbjct: 71 LRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAM 130 Query: 178 TYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQG 237 YL E + +HRD+ N+LV+ K+ DFG++ + + + + +PE L+ Sbjct: 131 EYL-EGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKL-PVKWTAPEALRE 188 Query: 238 THYSVQSDIWSMGLSLVEM-AVGRYPIPPPDAKELELMFGCQVEGDAAE-TPPRPRTPGR 295 +S +SD+WS G+ L E+ + GR P P K++ + DA + PP + Sbjct: 189 KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMK 248 Query: 296 PLSSYGMDSRPPMAIFE 312 RP Sbjct: 249 NCWHLDAAMRPSFLQLR 265 >3ORP-A nrPDB Length = 311 Score = 202 bits (513), Expect = 2e-52, Method: Composition-based stats. Identities = 57/213 (26%), Positives = 98/213 (46%), Gaps = 12/213 (5%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIH--LEIKPAIRNQIIRELQVLHECNS 123 D +E LG G V +A K++ L P+ + RE Q N Sbjct: 12 DRYELGEILGFGGMSEVHLARDLRDHRDVAVKVLRADLARDPSFYLRFRREAQNAAALNH 71 Query: 124 PYIVGFYGAFYSDGEI----SICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTY 179 P IV Y ++ I ME++DG +L ++ G + + +V + L + Sbjct: 72 PAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIVHTEGPMTPKRAIEVIADACQALNF 131 Query: 180 LREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS-----MANSFVGTRSYMSPER 234 ++ I+HRDVKP+NI++++ +K+ DFG++ + DS + +GT Y+SPE+ Sbjct: 132 SH-QNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGTAQYLSPEQ 190 Query: 235 LQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPD 267 +G +SD++S+G L E+ G P Sbjct: 191 ARGDSVDARSDVYSLGCVLYEVLTGEPPFTGDS 223 >4XCU-A nrPDB Length = 300 Score = 202 bits (513), Expect = 2e-52, Method: Composition-based stats. Identities = 68/319 (21%), Positives = 113/319 (35%), Gaps = 64/319 (20%) Query: 59 KVGELKDDDFEKISELGAGNGGVVFKVS-------HKPSGLVMARKLIHLEIKPAIRNQI 111 + E D LG G G V + +A K++ + Sbjct: 10 PLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADL 69 Query: 112 IRELQVLHEC-NSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKA-------GRIPE 163 + E++V+ I+ G +G + + +E G+L + L+ G + Sbjct: 70 VSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGSSEGPLSF 129 Query: 164 QILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSG--QLIDSMAN 221 +L + V +G+ YL + K +HRD+ N+LV +K+ DFG++ ID Sbjct: 130 PVLVSCAYQVARGMQYLESR-KCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKK 188 Query: 222 SFVGTR--SYMSPERLQGTHYSVQSDIWSMGLSLVEMAV-GRYPIPPPDAKELELMFGCQ 278 + G +M+PE L Y+ QSD+WS G+ L E+ G P P +EL F Sbjct: 189 TSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEEL---FSLL 245 Query: 279 VEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFV 338 EG + PP E + Sbjct: 246 REGHRMDRPPHC----------------------------------------PPELYGLM 265 Query: 339 NKCLIKNPAERADLKQLMV 357 +C P++R KQL+ Sbjct: 266 RECWHAAPSQRPTFKQLVE 284 >2OZO-A nrPDB Length = 613 Score = 202 bits (513), Expect = 3e-52, Method: Composition-based stats. Identities = 74/289 (25%), Positives = 126/289 (43%), Gaps = 13/289 (4%) Query: 57 KQKVGELKDDDFEKIS-ELGAGNGGVVFKV--SHKPSGLVMARKLIHLEIKPAIRNQIIR 113 K K LK D+ ELG GN G V + + + +A K++ + A +++R Sbjct: 326 KDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMR 385 Query: 114 ELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLK-KAGRIPEQILGKVSIA 172 E Q++H+ ++PYIV G ++ + + ME GG L + L K IP + ++ Sbjct: 386 EAQIMHQLDNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQ 444 Query: 173 VIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL--IDSMANSFVGTRS-- 228 V G+ YL EK+ +HR++ N+L+ +R K+ DFG+S L DS + + Sbjct: 445 VSMGMKYLEEKN-FVHRNLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPL 503 Query: 229 -YMSPERLQGTHYSVQSDIWSMGLSLVE-MAVGRYPIPPPDAKELELMFG-CQVEGDAAE 285 + +PE + +S +SD+WS G+++ E ++ G+ P E+ + E Sbjct: 504 KWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPE 563 Query: 286 TPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEF 334 PP Y + RP E G +LE Sbjct: 564 CPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGGSALEV 612 >5TQX-A nrPDB Length = 655 Score = 202 bits (513), Expect = 3e-52, Method: Composition-based stats. Identities = 70/313 (22%), Positives = 117/313 (37%), Gaps = 43/313 (13%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIV 127 +E LG G G V H+ L +A K LE+ R + E+Q++ + N +V Sbjct: 10 WEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCHEIQIMKKLNHANVV 69 Query: 128 GFYGAFYSDGEI-----SICMEHMDGGSLDQVLKK---AGRIPEQILGKVSIAVIKGLTY 179 + + ME+ GG L ++L K + E + + + G+ Y Sbjct: 70 KACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSGIRY 129 Query: 180 LREKHKIMHRDVKPSNILV-NSRGEI--KLCDFGVSGQLID-SMANSFVGTRSYMSPERL 235 L E +KI+HRD+KP NI++ + G+I K+ D G + + + FVGT Y++PE Sbjct: 130 LHE-NKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGELCTEFVGTLQYLAPELF 188 Query: 236 QGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGR 295 + Y+ D WS G + E G P + + R Sbjct: 189 ENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPKCIFACEEMSGEVR 248 Query: 296 PLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAER-----A 350 + + P P + ++++ L +P +R Sbjct: 249 --------------------FSSHLPQPNSLCSLIVEPMENWLQLMLNWDPQQRGGPVDL 288 Query: 351 DLKQ-----LMVH 358 LKQ LM H Sbjct: 289 TLKQPRCFVLMDH 301 >4HVI-A nrPDB Length = 314 Score = 202 bits (513), Expect = 3e-52, Method: Composition-based stats. Identities = 75/301 (24%), Positives = 123/301 (40%), Gaps = 42/301 (13%) Query: 63 LKDDDFEKISELGAGNGGVVFKVSHKP----SGLVMARKLIHLEIKPAIRNQIIRELQVL 118 ++ + IS+LG GN G V + P +G ++A K + P + RE+Q+L Sbjct: 7 FEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQ-HSGPDQQRDFQREIQIL 65 Query: 119 HECNSPYIVGFYGAFYSDGE--ISICMEHMDGGSLDQVLKKAG-RIPEQILGKVSIAVIK 175 +S +IV + G Y G + + ME++ G L L++ R+ L S + K Sbjct: 66 KALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICK 125 Query: 176 GLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRS-----YM 230 G+ YL + + +HRD+ NILV S +K+ DFG++ L V + Sbjct: 126 GMEYLGSR-RCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWY 184 Query: 231 SPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRP 290 +PE L +S QSD+WS G+ L E+ P A+ L +M G + P Sbjct: 185 APESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMM------GSERDVPALS 238 Query: 291 RTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERA 350 R + + PP P+ E + + C +P +R Sbjct: 239 RLLELLEEGQRLPA-----------------PPACPA-----EVHELMKLCWAPSPQDRP 276 Query: 351 D 351 Sbjct: 277 S 277 >5GNK-A nrPDB Length = 297 Score = 201 bits (512), Expect = 3e-52, Method: Composition-based stats. Identities = 66/277 (23%), Positives = 120/277 (43%), Gaps = 19/277 (6%) Query: 63 LKDDDFEKISELGAGNGGVVFKVSHKPSGLV----MARKLIHLEIKPAIRNQIIRELQVL 118 LK+ +F+KI LG+G G V+K P G +A K + P +I+ E V+ Sbjct: 16 LKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVM 75 Query: 119 HECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKA-GRIPEQILGKVSIAVIKGL 177 ++P++ G + + + M+ M G L +++ I Q L + + KG+ Sbjct: 76 ASVDNPHVCRLLGICLTST-VQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGM 134 Query: 178 TYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL-IDSMANSFVGTR---SYMSPE 233 YL ++ +++HRD+ N+LV + +K+ DFG++ L + G + +M+ E Sbjct: 135 NYLEDR-RLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALE 193 Query: 234 RLQGTHYSVQSDIWSMGLSLVEMAV-GRYPIPPPDAKELELMFGCQVEGDAAETPPRPRT 292 + Y+ QSD+WS G+++ E+ G P A E+ + +G+ PP Sbjct: 194 SILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILE---KGERLPQPPICTI 250 Query: 293 PGR----PLSSYGMDSRPPMAIFELLDYIVNEPPPKL 325 DSRP + + P + Sbjct: 251 DVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRY 287 >3KUL-B nrPDB Length = 325 Score = 201 bits (512), Expect = 4e-52, Method: Composition-based stats. Identities = 62/282 (21%), Positives = 106/282 (37%), Gaps = 13/282 (4%) Query: 62 ELKDDDFEKISELGAGNGGVVFKVSHKPSGL---VMARKLIHLEIKPAIRNQIIRELQVL 118 E++ +G+G+ G V + G +A K + R + E ++ Sbjct: 45 EIEASRIHIEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGYTERQRRDFLSEASIM 104 Query: 119 HECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKA-GRIPEQILGKVSIAVIKGL 177 + + P I+ G I E+M+ GSLD L+ G+ L + V G+ Sbjct: 105 GQFDHPNIIRLEGVVTRGRLAMIVTEYMENGSLDTFLRTHDGQFTIMQLVGMLRGVGAGM 164 Query: 178 TYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGT-----RSYMSP 232 YL +HRD+ N+LV+S K+ DFG+S L D ++ T + +P Sbjct: 165 RYL-SDLGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTAP 223 Query: 233 ERLQGTHYSVQSDIWSMGLSLVE-MAVGRYPIPPPDAKE-LELMFGCQVEGDAAETPPRP 290 E + +S SD+WS G+ + E +A G P ++ + + P Sbjct: 224 EAIAFRTFSSASDVWSFGVVMWEVLAYGERPYWNMTNRDVISSVEEGYRLPAPMGCPHAL 283 Query: 291 RTPGRPLSSYGMDSRPPM-AIFELLDYIVNEPPPKLPSGVFS 331 RP I +LD ++ P + S Sbjct: 284 HQLMLDCWHKDRAQRPRFSQIVSVLDALIRSPESLRATATVS 325 >6DBN-A nrPDB Length = 316 Score = 201 bits (511), Expect = 4e-52, Method: Composition-based stats. Identities = 69/313 (22%), Positives = 126/313 (40%), Gaps = 28/313 (8%) Query: 44 EQQRKRLEAFLTQKQKVGELKDDDFEK-----ISELGAGNGGVVFKVSHKP----SGLVM 94 + ++ +++K+ E+ FEK I +LG G+ G V + P +G + Sbjct: 8 NKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQV 67 Query: 95 ARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGE--ISICMEHMDGGSLD 152 A K + E + +E+++L IV + G DG I + ME + GSL Sbjct: 68 AVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLK 127 Query: 153 QVL-KKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGV 211 + L K +I + K ++ + KG+ YL + + HRD+ N+LV S ++K+ DFG+ Sbjct: 128 EYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYV-HRDLAARNVLVESEHQVKIGDFGL 186 Query: 212 SGQLIDSMANSFVGTRS-----YMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPP 266 + + V + +PE L + + + SD+WS G++L E+ Sbjct: 187 TKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLT----YCDS 242 Query: 267 DAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLP 326 D+ + L T R + P +++L+ P Sbjct: 243 DSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRT 302 Query: 327 SGVFSLEFQDFVN 339 S FQ+ + Sbjct: 303 S------FQNLIE 309 >5FM2-A nrPDB Length = 355 Score = 201 bits (510), Expect = 5e-52, Method: Composition-based stats. Identities = 70/296 (23%), Positives = 115/296 (38%), Gaps = 38/296 (12%) Query: 45 QQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKV-----SHKPSGLVMARKLI 99 + + ++AF + E + LG G G V K + +A K++ Sbjct: 43 ENQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKML 102 Query: 100 HLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAG 159 P+ ++ E VL + N P+++ YGA DG + + +E+ GSL L+++ Sbjct: 103 KENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESR 162 Query: 160 R------------------------IPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSN 195 + + L + + +G+ YL E K++HRD+ N Sbjct: 163 KVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEM-KLVHRDLAARN 221 Query: 196 ILVNSRGEIKLCDFGVSGQLI--DSMANSFVGTR--SYMSPERLQGTHYSVQSDIWSMGL 251 ILV ++K+ DFG+S + DS G +M+ E L Y+ QSD+WS G+ Sbjct: 222 ILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGV 281 Query: 252 SLVEMAV-GRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRP 306 L E+ G P P E +F G E P L P Sbjct: 282 LLWEIVTLGGNPYPGIPP---ERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEP 334 >5TOS-A nrPDB Length = 395 Score = 201 bits (510), Expect = 5e-52, Method: Composition-based stats. Identities = 71/314 (22%), Positives = 126/314 (40%), Gaps = 45/314 (14%) Query: 62 ELKDDDFEKISELGAGNGGVVFKV---------SHKPSGLVMARKLIHLEIKPAIRNQII 112 +L +F S +G G G VFK + +GLV+A K ++ E R + + Sbjct: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHR-EWL 119 Query: 113 RELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAG----RIPEQILGK 168 E+ L + + P +V G D + E M GSL+ L + G +P + Sbjct: 120 TEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVN 179 Query: 169 VSIAVIKGLTYLREKH-KIMHRDVKPSNILVNSRGEIKLCDFGVSGQLI----DSMANSF 223 V++ KGL +L K+++RD+K SNIL+++ KL DFG++ ++ Sbjct: 180 VALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRV 239 Query: 224 VGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDA 283 +GT Y +PE + H + +SD++S G+ L+E+ G+ + Sbjct: 240 MGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDH------------------ 281 Query: 284 AETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLI 343 P + Y R + I + P + ++ +CL Sbjct: 282 -NRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAV-------QCLS 333 Query: 344 KNPAERADLKQLMV 357 P R + Q++ Sbjct: 334 FEPKSRPTMDQVVR 347 >3LZB-A nrPDB Length = 327 Score = 201 bits (510), Expect = 6e-52, Method: Composition-based stats. Identities = 66/277 (23%), Positives = 120/277 (43%), Gaps = 19/277 (6%) Query: 63 LKDDDFEKISELGAGNGGVVFKVSHKPSGLV----MARKLIHLEIKPAIRNQIIRELQVL 118 LK+ +F+KI LG+G G V+K P G +A K + P +I+ E V+ Sbjct: 12 LKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVM 71 Query: 119 HECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKA-GRIPEQILGKVSIAVIKGL 177 ++P++ G + + + + M G L +++ I Q L + + KG+ Sbjct: 72 ASVDNPHVCRLLGICLTST-VQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGM 130 Query: 178 TYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL-IDSMANSFVGTR---SYMSPE 233 YL ++ +++HRD+ N+LV + +K+ DFG++ L + G + +M+ E Sbjct: 131 NYLEDR-RLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALE 189 Query: 234 RLQGTHYSVQSDIWSMGLSLVEMAV-GRYPIPPPDAKELELMFGCQVEGDAAETPPRPRT 292 + Y+ QSD+WS G+++ E+ G P A E+ + +G+ PP Sbjct: 190 SILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILE---KGERLPQPPICTI 246 Query: 293 P----GRPLSSYGMDSRPPMAIFELLDYIVNEPPPKL 325 R DSRP + + P + Sbjct: 247 DVYMIMRKCWMIDADSRPKFRELIIEFSKMARDPQRY 283 >2PVN-A nrPDB Length = 352 Score = 200 bits (509), Expect = 7e-52, Method: Composition-based stats. Identities = 73/314 (23%), Positives = 126/314 (40%), Gaps = 28/314 (8%) Query: 65 DDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHEC-NS 123 DD+E + ++G G VF+ + + K I +KP + +I RE+++L Sbjct: 51 QDDYEVVRKVGRGKYSEVFEGINVNNNE----KCIIKILKPVKKKKIKREIKILQNLCGG 106 Query: 124 PYIVGFYGAFYSDGEI--SICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLR 181 P IV S+ E+++ +VL + + + ++K L Y Sbjct: 107 PNIVKLLDIVRDQHSKTPSLIFEYVNNTD-FKVL--YPTLTDYDIRYYIYELLKALDYCH 163 Query: 182 EKHKIMHRDVKPSNILVNSR-GEIKLCDFGVSGQLI-DSMANSFVGTRSYMSPERLQG-T 238 + IMHRDVKP N++++ +++L D+G++ N V +R + PE L Sbjct: 164 SQ-GIMHRDVKPHNVMIDHELRKLRLIDWGLAEFYHPGKEYNVRVASRYFKGPELLVDLQ 222 Query: 239 HYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEG----DAAETPPRPRTPG 294 Y D+WS+G M + P +L+ +V G +A R Sbjct: 223 DYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKIAKVLGTDGLNAYLNKYRIELDP 282 Query: 295 RPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQ 354 + + G SR P F D + S E DF++K L + ER + Sbjct: 283 QLEALVGRHSRKPWLKFMNAD----------NQHLVSPEAIDFLDKLLRYDHQERLTALE 332 Query: 355 LMVHAFIKRSDAEE 368 M H + ++ A E Sbjct: 333 AMTHPYFQQVRAAE 346 >2HK5-A nrPDB Length = 270 Score = 200 bits (509), Expect = 7e-52, Method: Composition-based stats. Identities = 57/256 (22%), Positives = 109/256 (42%), Gaps = 14/256 (5%) Query: 57 KQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQ 116 ++ E+ + + +LGAG G V+ ++ +A K + + E Sbjct: 6 EKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTK-VAVKTMKPGSMSV--EAFLAEAN 62 Query: 117 VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLK--KAGRIPEQILGKVSIAVI 174 V+ +V + + I I E M GSL LK + + P L S + Sbjct: 63 VMKTLQHDKLVKLHAVV-TKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIA 121 Query: 175 KGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTR---SYMS 231 +G+ ++ +++ I HRD++ +NILV++ K+ DFG++ + D+ + G + + + Sbjct: 122 EGMAFIEQRNYI-HRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTA 180 Query: 232 PERLQGTHYSVQSDIWSMGLSLVEMAV-GRYPIPPPDAKELELMFGCQVEGDAAETPPRP 290 PE + ++++SD+WS G+ L+E+ GR P P E+ G P Sbjct: 181 PEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEV---IRALERGYRMPRPENC 237 Query: 291 RTPGRPLSSYGMDSRP 306 + +RP Sbjct: 238 PEELYNIMMRCWKNRP 253 >4R7H-A nrPDB Length = 343 Score = 200 bits (509), Expect = 7e-52, Method: Composition-based stats. Identities = 60/288 (20%), Positives = 111/288 (38%), Gaps = 37/288 (12%) Query: 59 KVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLV-----MARKLIHLEIKPAIRNQIIR 113 + E ++ + LGAG G V + + G +A K++ + ++ Sbjct: 43 EKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMS 102 Query: 114 ELQVLHEC-NSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKA-------------- 158 EL+++ IV GA G + + E+ G L L++ Sbjct: 103 ELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCTYGDLLNFLRRKAEAMLGPSLSPGQD 162 Query: 159 ---------GRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDF 209 + + L S V +G+ +L K+ +HRDV N+L+ + K+ DF Sbjct: 163 PEGLDKEDGRPLELRDLLHFSSQVAQGMAFLASKN-CIHRDVAARNVLLTNGHVAKIGDF 221 Query: 210 GVSGQLIDSMANSFVGTRS----YMSPERLQGTHYSVQSDIWSMGLSLVEMAV-GRYPIP 264 G++ +++ G +M+PE + + Y+VQSD+WS G+ L E+ G P P Sbjct: 222 GLARDIMNDSNYIVKGNARLPVKWMAPESIFDSVYTVQSDVWSYGILLWEIFSLGLNPYP 281 Query: 265 PP--DAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAI 310 ++K +L+ A P + + + RP Sbjct: 282 GILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQ 329 >5HVK-A nrPDB Length = 315 Score = 200 bits (509), Expect = 9e-52, Method: Composition-based stats. Identities = 63/272 (23%), Positives = 109/272 (40%), Gaps = 26/272 (9%) Query: 63 LKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECN 122 + D LG G G KV+H+ +G VM K + + + ++E++V+ Sbjct: 11 FRPSDLIHGEVLGKGCFGQAIKVTHRETGEVMVMKEL-IRFDEETQRTFLKEVKVMRCLE 69 Query: 123 SPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAG-RIPEQILGKVSIAVIKGLTYLR 181 P ++ F G Y D ++ E++ GG+L ++K + P + + G+ YL Sbjct: 70 HPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLH 129 Query: 182 EKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA----------------NSFVG 225 + I+HR++ N LV + + DFG++ ++D + VG Sbjct: 130 SMN-IIHRNLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVG 188 Query: 226 TRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEG---- 281 +M+PE + G Y + D++S G+ L E+ GR PD + FG V G Sbjct: 189 NPYWMAPEMINGRSYDEKVDVFSFGIVLCEII-GRVN-ADPDYLPRTMDFGLNVRGFLDR 246 Query: 282 -DAAETPPRPRTPGRPLSSYGMDSRPPMAIFE 312 PP + RP E Sbjct: 247 YCPPNCPPSFFPITVRCCDLDPEKRPSFVKLE 278 >4M7I-A nrPDB Length = 299 Score = 200 bits (508), Expect = 1e-51, Method: Composition-based stats. Identities = 74/283 (26%), Positives = 117/283 (41%), Gaps = 36/283 (12%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPY 125 DFE I LG G GVVF+ +K A K I L + R +++RE++ L + P Sbjct: 5 TDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPG 64 Query: 126 IVGFYGAFYSDG------------EISICMEHMDGGSLDQVLKKAGRIPEQILG---KVS 170 IV ++ A+ + I M+ +L + I E+ + Sbjct: 65 IVRYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIF 124 Query: 171 IAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSM----------- 219 + + + + +L K +MHRD+KPSNI +K+ DFG+ + Sbjct: 125 LQIAEAVEFLHSK-GLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPA 183 Query: 220 ---ANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFG 276 VGT+ YMSPE++ G YS + DI+S+GL L E+ YP + L Sbjct: 184 YARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELL---YPFSTQMERVRTLTDV 240 Query: 277 CQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVN 319 ++ T + P + M S PM E ++ I N Sbjct: 241 RNLKFPPLFT---QKYPCEYVMVQDMLSPSPMERPEAINIIEN 280 >2PSQ-A nrPDB Length = 370 Score = 199 bits (507), Expect = 1e-51, Method: Composition-based stats. Identities = 64/274 (23%), Positives = 112/274 (40%), Gaps = 33/274 (12%) Query: 43 DEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKV------SHKPSG-LVMA 95 D + + + E D LG G G V KP + +A Sbjct: 58 DTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVA 117 Query: 96 RKLIHLEIKPAIRNQIIRELQVLHEC-NSPYIVGFYGAFYSDGEISICMEHMDGGSLDQV 154 K++ + + ++ E++++ I+ GA DG + + +E+ G+L + Sbjct: 118 VKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREY 177 Query: 155 LKKA-----------GRIPEQI-----LGKVSIAVIKGLTYLREKHKIMHRDVKPSNILV 198 L+ R+PE+ L + + +G+ YL + K +HRD+ N+LV Sbjct: 178 LRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQ-KCIHRDLAARNVLV 236 Query: 199 NSRGEIKLCDFGVSGQL--IDSMANSFVGTR--SYMSPERLQGTHYSVQSDIWSMGLSLV 254 +K+ DFG++ + ID + G +M+PE L Y+ QSD+WS G+ + Sbjct: 237 TENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMW 296 Query: 255 EMAV-GRYPIPPPDAKELELMFGCQVEGDAAETP 287 E+ G P P +EL F EG + P Sbjct: 297 EIFTLGGSPYPGIPVEEL---FKLLKEGHRMDKP 327 >5GRN-A nrPDB Length = 356 Score = 199 bits (506), Expect = 2e-51, Method: Composition-based stats. Identities = 66/341 (19%), Positives = 117/341 (34%), Gaps = 41/341 (12%) Query: 37 LEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVS-----HKPSG 91 +E + D + ++ E D LG+G G V + + Sbjct: 17 IESISPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPV 76 Query: 92 LVMARKLIHLEIKPAIRNQIIRELQVLHECN-SPYIVGFYGAFYSDGEISICMEHMDGGS 150 + +A K++ + + + ++ EL+++ IV GA G I I E+ G Sbjct: 77 MKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGD 136 Query: 151 LDQVLKKAGR--------------------------IPEQILGKVSIAVIKGLTYLREKH 184 L L K + L + V +G+ +L K+ Sbjct: 137 LVNYLHKNRDSFLSHKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKN 196 Query: 185 KIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGT----RSYMSPERLQGTHY 240 +HRD+ N+L+ +K+CDFG++ ++ G+ +M+PE + Y Sbjct: 197 -CVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLY 255 Query: 241 SVQSDIWSMGLSLVEMAV-GRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSS 299 + SD+WS G+ L E+ G P P + G P + + Sbjct: 256 TTLSDVWSYGILLWEIFSLGGTPYPGM--MVDSTFYNKIKSGYRMAKPDHATSEVYEIMV 313 Query: 300 YGMDSRP-PMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVN 339 +S P F L IV P + DF+ Sbjct: 314 KCWNSEPEKRPSFYHLSEIVENLLPGQYKKSYEKIHLDFLK 354 >5O0Y-A nrPDB Length = 579 Score = 199 bits (506), Expect = 2e-51, Method: Composition-based stats. Identities = 85/375 (22%), Positives = 148/375 (39%), Gaps = 63/375 (16%) Query: 24 SSAETNLEALQKKLEELE-LDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVV 82 E ++A ++LE + L ++ KR+ + K +D + + LG G V Sbjct: 241 KKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEV 300 Query: 83 FKVSHKPSGLVMARKL--IHL----EIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSD 136 +K +A K+ ++ E K RE ++ E + P IV Y F D Sbjct: 301 YKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLD 360 Query: 137 GE-ISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLRE-KHKIMHRDVKPS 194 + +E+ +G LD LK+ + E+ + + ++ L YL E K I+H D+KP Sbjct: 361 TDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPG 420 Query: 195 NILV---NSRGEIKLCDFGVSGQLIDSMANSF---------VGTRSYMSPERL----QGT 238 NIL+ + GEIK+ DFG+S + D NS GT Y+ PE + Sbjct: 421 NILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPP 480 Query: 239 HYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLS 298 S + D+WS+G+ + GR P +++ L ++ + PP+P Sbjct: 481 KISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKP-------- 532 Query: 299 SYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVH 358 V + E + F+ +CL +R D++QL Sbjct: 533 ------------------------------VVTPEAKAFIRRCLAYRKEDRIDVQQLACD 562 Query: 359 AFIKRSDAEEVDFAG 373 ++ + V + Sbjct: 563 PYLLPHIRKSVSTSS 577 >5HI2-A nrPDB Length = 283 Score = 199 bits (505), Expect = 2e-51, Method: Composition-based stats. Identities = 56/269 (20%), Positives = 108/269 (40%), Gaps = 23/269 (8%) Query: 56 QKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIREL 115 E+ D +G+G+ G V+K +A K++ P E+ Sbjct: 10 DSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD---VAVKML----TPQQLQAFKNEV 62 Query: 116 QVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLK-KAGRIPEQILGKVSIAVI 174 VL + I+ F G + + +++I + +G SL L + + L ++ Sbjct: 63 GVLRKTRHVNILLFMG-YSTKPQLAIVTQWCEGSSLYHHLHASETKFEMKKLIDIARQTA 121 Query: 175 KGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVS----GQLIDSMANSFVGTRSYM 230 +G+ YL K I+HRD+K +NI ++ +K+ DFG++ G+ +M Sbjct: 122 RGMDYLHAK-SIIHRDLKSNNIFLHEDNTVKIGDFGLATVKSRWSGSHQFEQLSGSILWM 180 Query: 231 SPERLQ---GTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQ------VEG 281 +PE ++ YS QSD+++ G+ L E+ G+ P + ++ + + + Sbjct: 181 APEVIRMQDSNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEMVGRGSLSPDLSK 240 Query: 282 DAAETPPRPRTPGRPLSSYGMDSRPPMAI 310 + P R + D RP Sbjct: 241 VRSNCPKRMKRLMAECLKKKRDERPSFPR 269 >3QUP-A nrPDB Length = 323 Score = 198 bits (504), Expect = 3e-51, Method: Composition-based stats. Identities = 60/336 (17%), Positives = 125/336 (37%), Gaps = 73/336 (21%) Query: 37 LEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSG---LV 93 L+ L + ++ +++LE L +Q+ F LG G G V + K + Sbjct: 2 LDSLGISDELKEKLEDVLIPEQQ--------FTLGRMLGKGEFGSVREAQLKQEDGSFVK 53 Query: 94 MARKLIHLEI-KPAIRNQIIRELQVLHECNSPYIVGFYGAFYS---DGEI---SICMEHM 146 +A K++ +I + + +RE + E + P++ G G + + + M Sbjct: 54 VAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFM 113 Query: 147 DGGSLDQVL------KKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNS 200 G L L + +P Q L + + + G+ YL ++ +HRD+ N ++ Sbjct: 114 KHGDLHAFLLASRIGENPFNLPLQTLVRFMVDIACGMEYLSSRN-FIHRDLAARNCMLAE 172 Query: 201 RGEIKLCDFGVSGQLIDSMANSF-VGTR---SYMSPERLQGTHYSVQSDIWSMGLSLVEM 256 + + DFG+S ++ ++ +++ E L Y+V SD+W+ G+++ E+ Sbjct: 173 DMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVHSDVWAFGVTMWEI 232 Query: 257 AV-GRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLD 315 G+ P + E ++ + G+ + PP Sbjct: 233 MTRGQTPYAGIENAE---IYNYLIGGNRLKQPPECM------------------------ 265 Query: 316 YIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERAD 351 E D + +C +P +R Sbjct: 266 ----------------EEVYDLMYQCWSADPKQRPS 285 >3I81-A nrPDB Length = 315 Score = 198 bits (504), Expect = 3e-51, Method: Composition-based stats. Identities = 63/297 (21%), Positives = 110/297 (37%), Gaps = 22/297 (7%) Query: 61 GELKDDDFEKISELGAGNGGVVFKVSHK-----PSGLVMARKLIHLEIKPAIRNQIIREL 115 E+ + ELG G+ G+V++ K +A K ++ R + + E Sbjct: 13 WEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEA 72 Query: 116 QVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPE----------QI 165 V+ E N ++V G + ME M G L L+ E Sbjct: 73 SVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSK 132 Query: 166 LGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVG 225 + +++ + G+ YL +K +HRD+ N +V +K+ DFG++ + ++ G Sbjct: 133 MIQMAGEIADGMAYL-NANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGG 191 Query: 226 ----TRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAV-GRYPIPPPDAKE-LELMFGCQV 279 +MSPE L+ ++ SD+WS G+ L E+A P ++ L + + Sbjct: 192 KGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGL 251 Query: 280 EGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQD 336 P R Y RP EP + S +S E + Sbjct: 252 LDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENKM 308 >6CCF-A nrPDB Length = 290 Score = 198 bits (504), Expect = 3e-51, Method: Composition-based stats. Identities = 66/333 (19%), Positives = 125/333 (37%), Gaps = 76/333 (22%) Query: 63 LKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAI--------------- 107 ++ + ++ SE+G G GVV ++ A K++ + Sbjct: 2 MQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAA 61 Query: 108 ----------RNQIIRELQVLHECNSPYIVGFYGAFYS--DGEISICMEHMDGGSLDQVL 155 ++ +E+ +L + + +V + + + + + G + +V Sbjct: 62 QGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEVP 121 Query: 156 KKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL 215 E+ VI GL YL + KI+HRD+KPSN+L+ G +K+ DFGVS Q Sbjct: 122 CDK-PFSEEQARLYLRDVILGLEYLHCQ-KIVHRDIKPSNLLLGDDGHVKIADFGVSNQF 179 Query: 216 I--DSMANSFVGTRSYMSPERLQGTHYS---VQSDIWSMGLSLVEMAVGRYPIPPPDAKE 270 D+ +S GT ++M+PE + + S D+W+ G++L G+ P + Sbjct: 180 EGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPF----IDD 235 Query: 271 LELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVF 330 L +++ + P P Sbjct: 236 FILALHRKIKNEPVVFPEEPE--------------------------------------I 257 Query: 331 SLEFQDFVNKCLIKNPAERADLKQLMVHAFIKR 363 S E +D + K L KNP R + + +H ++ + Sbjct: 258 SEELKDLILKMLDKNPETRIGVPDIKLHPWVTK 290 >2PMN-X nrPDB Length = 348 Score = 198 bits (503), Expect = 4e-51, Method: Composition-based stats. Identities = 77/343 (22%), Positives = 128/343 (37%), Gaps = 52/343 (15%) Query: 53 FLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRN--- 109 +L + K + +D+ I L G + A K + R+ Sbjct: 18 YLNKYVKEKDKYINDYRIIRTLNQGKFNKIILCE--KDNKFYALKKYEKSLLEKKRDFTK 75 Query: 110 -------------QIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQV-- 154 ELQ++ + + Y + G + E+ I E+M+ S+ + Sbjct: 76 SNNDKISIKSKYDDFKNELQIITDIKNEYCLTCEGIITNYDEVYIIYEYMENDSILKFDE 135 Query: 155 ----LKKAG--RIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCD 208 L K IP Q++ + +V+ +Y+ + I HRDVKPSNIL++ G +KL D Sbjct: 136 YFFVLDKNYTCFIPIQVIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMDKNGRVKLSD 195 Query: 209 FGVSGQLIDSMANSFVGTRSYMSPERL-QGTHY-SVQSDIWSMGLSLVEMAVGRYPIPPP 266 FG S ++D GT +M PE + Y + DIWS+G+ L M P Sbjct: 196 FGESEYMVDKKIKGSRGTYEFMPPEFFSNESSYNGAKVDIWSLGICLYVMFYNVVPF--- 252 Query: 267 DAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLP 326 K + + E P PL++ Sbjct: 253 SLKISLVELFNNIRTKNIEYPLDRNHFLYPLTN---------------------KKSTCS 291 Query: 327 SGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEV 369 + S E DF+ L KNPAER + + H ++ ++ E++ Sbjct: 292 NNFLSNEDIDFLKLFLRKNPAERITSEDALKHEWLADTNIEDL 334 >4IAN-A nrPDB Length = 358 Score = 198 bits (503), Expect = 4e-51, Method: Composition-based stats. Identities = 71/335 (21%), Positives = 139/335 (41%), Gaps = 31/335 (9%) Query: 56 QKQKVGELKDDDFEKISELGAGNGGVVFKVSHK-PSGLVMARKLIHLEIKPAIRNQIIRE 114 + +GE+ D + G G V + + +A K+I ++ ++E Sbjct: 20 YRVNIGEVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIR--NNELMQKTGLKE 77 Query: 115 LQVLHECN------SPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR---IPEQI 165 L+ L + N + + + FY + + E + +L +VLKK G+ + + Sbjct: 78 LEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSM-NLREVLKKYGKDVGLHIKA 136 Query: 166 LGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEI-KLCDFGVSGQLIDSMANSFV 224 + S + L L ++ I+H D+KP NILVN I KLCDFG + + D+ ++ Sbjct: 137 VRSYSQQLFLALK-LLKRCNILHADIKPDNILVNESKTILKLCDFGSASHVADNDITPYL 195 Query: 225 GTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKEL---------ELMF 275 +R Y +PE + G Y D+WS+G +L E+ G+ P + ++ Sbjct: 196 VSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPN 255 Query: 276 GCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPP-----KLPSGVF 330 +G + + + R + + ++ + +LP Sbjct: 256 KMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLADLIGCQRLPEDQR 315 Query: 331 SL--EFQDFVNKCLIKNPAERADLKQLMVHAFIKR 363 + +D +++ L+ +PA+R + Q + HAFI+ Sbjct: 316 KKVHQLKDLLDQILMLDPAKRISINQALQHAFIQE 350 >5U6B-A nrPDB Length = 307 Score = 197 bits (502), Expect = 5e-51, Method: Composition-based stats. Identities = 63/341 (18%), Positives = 123/341 (36%), Gaps = 74/341 (21%) Query: 36 KLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSG--LV 93 L + E+ +++L + + KV LG G G V + L Sbjct: 1 GSNSLGISEELKEKLRDVMVDRHKVA--------LGKTLGEGEFGAVMEGQLNQDDSILK 52 Query: 94 MARKLIHLEIKPAIR-NQIIRELQVLHECNSPYIVGFYGAFYSDGEI------SICMEHM 146 +A K + + I + E + E + P ++ G + E + + M Sbjct: 53 VAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFM 112 Query: 147 DGGSLDQVL------KKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNS 200 G L L + +P Q+L K + G+ YL K + +HRD+ N ++N Sbjct: 113 KHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGMEYLSTK-RFIHRDLAARNCMLNE 171 Query: 201 RGEIKLCDFGVSGQLIDSMANSFVGTR-----SYMSPERLQGTHYSVQSDIWSMGLSLVE 255 + + DFG+S ++ + G +++ E L Y+ +SD+WS G+++ E Sbjct: 172 NMSVCVADFGLSKKIYNGDYY-RQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWE 230 Query: 256 MAV-GRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELL 314 +A G+ P P + E ++ +G+ + P Sbjct: 231 IATRGQTPYPGVENSE---IYDYLRQGNRLKQP--------------------------- 260 Query: 315 DYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQL 355 G+++ +++C NP +R +L Sbjct: 261 --------ADCLDGLYA-----LMSRCWELNPQDRPSFTEL 288 >5EG3-A nrPDB Length = 334 Score = 197 bits (502), Expect = 5e-51, Method: Composition-based stats. Identities = 68/314 (21%), Positives = 121/314 (38%), Gaps = 36/314 (11%) Query: 53 FLTQKQKVGELKDDDFEKISELGAGNGGVVFKV------SHKPSG-LVMARKLIHLEIKP 105 F + E D LG G G V KP + +A K++ + Sbjct: 22 FELPEDPKWEFPRDKLTLGKPLGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATE 81 Query: 106 AIRNQIIRELQVLHEC-NSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKA------ 158 + ++ E++++ I+ GA DG + + + + G+L + L+ Sbjct: 82 KDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVAYASKGNLREYLRARRPPGME 141 Query: 159 -----GRIPEQI-----LGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCD 208 R+PE+ L + + +G+ YL + K +HRD+ N+LV +K+ D Sbjct: 142 LSPDINRVPEEQMTFKDLVSCTYQLARGMEYLASQ-KCIHRDLAARNVLVTENNVMKIAD 200 Query: 209 FGVSGQL--IDSMANSFVGTR--SYMSPERLQGTHYSVQSDIWSMGLSLVEMAV-GRYPI 263 FG++ + ID + G +M+PE L Y+ QSD+WS G+ + E+ G P Sbjct: 201 FGLARDINNIDFFKETTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPY 260 Query: 264 PPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPP 323 P +EL F EG + P L D + + E Sbjct: 261 PGIPVEEL---FKLLKEGHRMDKP---ANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLD 314 Query: 324 KLPSGVFSLEFQDF 337 ++ + + E+ D Sbjct: 315 RILTLTTNEEYLDL 328 >1FVR-A nrPDB Length = 327 Score = 197 bits (501), Expect = 7e-51, Method: Composition-based stats. Identities = 71/312 (22%), Positives = 111/312 (35%), Gaps = 65/312 (20%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVM--ARKLIHLEIKPAIRNQIIRELQVLHEC-N 122 +D + +G GN G V K K GL M A K + EL+VL + + Sbjct: 25 NDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGH 84 Query: 123 SPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKK----------------AGRIPEQIL 166 P I+ GA G + + +E+ G+L L+K A + Q L Sbjct: 85 HPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQL 144 Query: 167 GKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGT 226 + V +G+ YL + + +HRD+ NILV K+ DFG+S + + Sbjct: 145 LHFAADVARGMDYL-SQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRL 203 Query: 227 R-SYMSPERLQGTHYSVQSDIWSMGLSLVEMAV-GRYPIPPPDAKELELMFGCQVEGDAA 284 +M+ E L + Y+ SD+WS G+ L E+ G P EL + +G Sbjct: 204 PVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAEL---YEKLPQGYRL 260 Query: 285 ETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIK 344 E P E D + +C + Sbjct: 261 EKPLNC----------------------------------------DDEVYDLMRQCWRE 280 Query: 345 NPAERADLKQLM 356 P ER Q++ Sbjct: 281 KPYERPSFAQIL 292 >6GVJ-A nrPDB Length = 429 Score = 197 bits (501), Expect = 7e-51, Method: Composition-based stats. Identities = 69/313 (22%), Positives = 121/313 (38%), Gaps = 63/313 (20%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIR-ELQVLHECN--SP 124 + + ++G+G VF+V + + A K ++LE R E+ L++ S Sbjct: 146 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 204 Query: 125 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKH 184 I+ Y +D I + ME L+ LKK I +++ + + +H Sbjct: 205 KIIRLYDYEITDQYIYMVME-CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIH-QH 262 Query: 185 KIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA----NSFVGTRSYMSPERLQGTHY 240 I+H D+KP+N L+ G +KL DFG++ Q+ +S VGT +YM PE ++ Sbjct: 263 GIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSS 321 Query: 241 SVQ-----------SDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPR 289 S + SD+WS+G L M G+ P + +L E P Sbjct: 322 SRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPN-HEIEFPDI 380 Query: 290 PRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAER 349 P + QD + CL ++P +R Sbjct: 381 PE----------------------------------------KDLQDVLKCCLKRDPKQR 400 Query: 350 ADLKQLMVHAFIK 362 + +L+ H +++ Sbjct: 401 ISIPELLAHPYVQ 413 >4FL3-A nrPDB Length = 635 Score = 197 bits (501), Expect = 7e-51, Method: Composition-based stats. Identities = 74/325 (22%), Positives = 139/325 (42%), Gaps = 19/325 (5%) Query: 4 KKPTPIQLNPAPDGSAVNGTSSAETNLEALQ-KKLEELELDEQQRKR-LEAFLTQKQKVG 61 +K +P Q N + N A + + E L +D + + + K Sbjct: 304 RKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVFESPFADPEEIRPKEV 363 Query: 62 ELKDDDFEKI-SELGAGNGGVVFKVSHK-----PSGLVMARKLIHLEIKPAIRNQIIREL 115 L ELG+GN G V K ++ + V K + PA++++++ E Sbjct: 364 YLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILK--NEANDPALKDELLAEA 421 Query: 116 QVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIK 175 V+ + ++PYIV G ++ + + ME + G L++ L++ + ++ + ++ V Sbjct: 422 NVMQQLDNPYIVRMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM 480 Query: 176 GLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGT-----RSYM 230 G+ YL E + +HRD+ N+L+ ++ K+ DFG+S L T + Sbjct: 481 GMKYLEESN-FVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY 539 Query: 231 SPERLQGTHYSVQSDIWSMGLSLVE-MAVGRYPIPPPDAKELELMFGC-QVEGDAAETPP 288 +PE + +S +SD+WS G+ + E + G+ P E+ M + G A P Sbjct: 540 APECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPR 599 Query: 289 RPRTPGRPLSSYGMDSRPPMAIFEL 313 +Y +++RP A EL Sbjct: 600 EMYDLMNLCWTYDVENRPGFAAVEL 624 >3EB0-A nrPDB Length = 383 Score = 197 bits (500), Expect = 8e-51, Method: Composition-based stats. Identities = 77/365 (21%), Positives = 135/365 (36%), Gaps = 68/365 (18%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIV 127 + LG G+ G+V +V SG A K + + + R EL ++ + I+ Sbjct: 9 YSLGKTLGTGSFGIVCEVFDIESGKRFALKKVLQDPRYKNR-----ELDIMKVLDHVNII 63 Query: 128 GFYGAFYS--------------------------------------DGEISICMEHMD-- 147 FY+ + +++ ME++ Sbjct: 64 KLVDYFYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNVIMEYVPDT 123 Query: 148 -GGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNS-RGEIK 205 L ++ IP ++ + + + ++ I HRD+KP N+LVNS +K Sbjct: 124 LHKVLKSFIRSGRSIPMNLISIYIYQLFRAVGFIHSL-GICHRDIKPQNLLVNSKDNTLK 182 Query: 206 LCDFGVSGQLIDSMAN-SFVGTRSYMSPERLQG-THYSVQSDIWSMGLSLVEMAVGRYPI 263 LCDFG + +LI S + +++ +R Y +PE + G T Y+ D+WS+G E+ +G+ P+ Sbjct: 183 LCDFGSAKKLIPSEPSVAYICSRFYRAPELMLGATEYTPSIDLWSIGCVFGELILGK-PL 241 Query: 264 PPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPP 323 + +L+ Q+ G P + P + Sbjct: 242 FSGETSIDQLVRIIQIMGT-------------PTKEQMIRMNPHYTEVRFPTLKAKDWRK 288 Query: 324 KLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFI---KRSDAEEVDFAGWLCSTIG 380 LP G SL D + + L P R + + M H F + S EV + Sbjct: 289 ILPEGTPSL-AIDLLEQILRYEPDLRINPYEAMAHPFFDHLRNSYESEVKNNSNFPHGVN 347 Query: 381 LNQPS 385 N P Sbjct: 348 QNIPQ 352 >6FER-A nrPDB Length = 309 Score = 197 bits (500), Expect = 8e-51, Method: Composition-based stats. Identities = 57/297 (19%), Positives = 99/297 (33%), Gaps = 41/297 (13%) Query: 58 QKVGELKDDDFEKISELGAGNGGVVFKV------SHKPSG----------LVMARKLIHL 101 V E +LG G G V K +++A K++ Sbjct: 1 VAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRA 60 Query: 102 EIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR- 160 + RN ++E++++ P I+ +D + + E+M+ G L+Q L + Sbjct: 61 DANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPP 120 Query: 161 ---------IPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGV 211 + L ++ + G+ YL +HRD+ N LV IK+ DFG+ Sbjct: 121 NSSSSDVRTVSYTNLKFMATQIASGMKYL-SSLNFVHRDLATRNCLVGKNYTIKIADFGM 179 Query: 212 SGQLIDSMANSFVGTR----SYMSPERLQGTHYSVQSDIWSMGLSLVE--MAVGRYPIPP 265 S L G +MS E + ++ SD+W+ G++L E P Sbjct: 180 SRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQ 239 Query: 266 PDAKELELMFG--------CQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELL 314 +++ G A P +RP LL Sbjct: 240 LSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIHLL 296 >4F0G-A nrPDB Length = 287 Score = 196 bits (498), Expect = 1e-50, Method: Composition-based stats. Identities = 65/273 (23%), Positives = 121/273 (44%), Gaps = 22/273 (8%) Query: 56 QKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRN------ 109 K ++ L D++ E ++G G G+V K V+A K + L Sbjct: 9 PKSRLPTLADNEIEYEKQIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQ 68 Query: 110 QIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSL-DQVLKKAGRIPEQILGK 168 + RE+ ++ N P IV YG ++ + ME + G L ++L KA I + + Sbjct: 69 EFQREVFIMSNLNHPNIVKLYGLMHNPPR--MVMEFVPCGDLYHRLLDKAHPIKWSVKLR 126 Query: 169 VSIAVIKGLTYLREKH-KIMHRDVKPSNILVNSRGE-----IKLCDFGVSGQLIDSMANS 222 + + + G+ Y++ ++ I+HRD++ NI + S E K+ DFG+S Q + S+ + Sbjct: 127 LMLDIALGIEYMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQSVHSV-SG 185 Query: 223 FVGTRSYMSPERL--QGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVE 280 +G +M+PE + + Y+ ++D +S + L + G P +++ + + E Sbjct: 186 LLGNFQWMAPETIGAEEESYTEKADTYSFAMILYTILTGEGPFDEYSYGKIKFINMIREE 245 Query: 281 GD----AAETPPRPRTPGRPLSSYGMDSRPPMA 309 G + PPR R S RP + Sbjct: 246 GLRPTIPEDCPPRLRNVIELCWSGDPKKRPHFS 278 >2X7G-A nrPDB Length = 389 Score = 196 bits (497), Expect = 2e-50, Method: Composition-based stats. Identities = 77/391 (19%), Positives = 131/391 (33%), Gaps = 79/391 (20%) Query: 43 DEQQRKRLEAFLT--QKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIH 100 DE+Q + K+G+L + + I +LG G+ V+ +A K++ Sbjct: 6 DEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVK 65 Query: 101 LEIKPAIRNQIIRELQVLHEC--------NSPYIVGFYGAFYSDG----EISICMEHMDG 148 + E+++L N +V F G + + E + Sbjct: 66 --SAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGH 123 Query: 149 GSLDQVLKKAGR-IPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILV--------- 198 L ++K + +P + + + V++GL YL K KI+H D+KP NIL+ Sbjct: 124 HLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRR 183 Query: 199 --------------------------------------NSRGEIKLCDFGVSGQLIDSMA 220 + +K+ D G + + Sbjct: 184 MAAEATEWQKAGAPPPSGSAVSTAPAADLLVNPLDPRNADKIRVKIADLGNAC-WVHKHF 242 Query: 221 NSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVE 280 + TR Y S E L G YS +DIWS E+A G Y P ++ + E Sbjct: 243 TEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLFEPHSGEDY-----SRDE 297 Query: 281 GDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKL---------PSGVFS 331 A + R + G SR L +I P L + Sbjct: 298 DHIAHIIELLGSIPRHFALSGKYSREFFNRRGELRHITKLKPWSLFDVLVEKYGWPHEDA 357 Query: 332 LEFQDFVNKCLIKNPAERADLKQLMVHAFIK 362 +F DF+ L P +RA + + H ++ Sbjct: 358 AQFTDFLIPMLEMVPEKRASAGECLRHPWLN 388 >4K33-A nrPDB Length = 325 Score = 196 bits (497), Expect = 2e-50, Method: Composition-based stats. Identities = 59/275 (21%), Positives = 105/275 (38%), Gaps = 33/275 (12%) Query: 42 LDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKV------SHKPSG-LVM 94 D + EL LG G G V + + + + Sbjct: 12 QDPPTLANVSELELPADPKWELSRARLTLGKPLGEGAFGQVVMAEAIGIDKDRAAKPVTV 71 Query: 95 ARKLIHLEIKPAIRNQIIRELQVLHEC-NSPYIVGFYGAFYSDGEISICMEHMDGGSLDQ 153 A K++ + + ++ E++++ I+ GA G + + +E+ G+L + Sbjct: 72 AVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLRE 131 Query: 154 VLKKAGR----------------IPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNIL 197 L+ + + L + V +G+ YL + K +HRD+ N+L Sbjct: 132 FLRARRPPGLDYSFDTSKPPEEQLTFKDLVSCAYQVARGMEYLASQ-KCIHRDLAARNVL 190 Query: 198 VNSRGEIKLCDFGVSGQLI--DSMANSFVGTR--SYMSPERLQGTHYSVQSDIWSMGLSL 253 V +K+ DFG++ + D + G +M+PE L Y+ QSD+WS G+ L Sbjct: 191 VTEDNVMKIADFGLARDVHNLDYYKETTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLL 250 Query: 254 VEMAV-GRYPIPPPDAKELELMFGCQVEGDAAETP 287 E+ G P P +EL F EG + P Sbjct: 251 WEIFTLGGSPYPGIPVEEL---FKLLKEGHRMDKP 282 >3G0E-A nrPDB Length = 336 Score = 195 bits (496), Expect = 2e-50, Method: Composition-based stats. Identities = 67/326 (20%), Positives = 110/326 (33%), Gaps = 72/326 (22%) Query: 61 GELKDDDFEKISELGAGNGGVVFKVS-----HKPSGLVMARKLIHLEIKPAIRNQIIREL 115 E + LGAG G V + + + + +A K++ R ++ EL Sbjct: 41 WEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSEL 100 Query: 116 QVLHEC-NSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAG--------------- 159 +VL N IV GA G + E+ G L L++ Sbjct: 101 KVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKTSPAIMED 160 Query: 160 ---RIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLI 216 + + L S V KG+ +L K+ +HRD+ NIL+ K+CDFG++ + Sbjct: 161 DELALDLEDLLSFSYQVAKGMAFLASKN-CIHRDLAARNILLTHGRITKICDFGLARDIK 219 Query: 217 DSMANSFVGTRS----YMSPERLQGTHYSVQSDIWSMGLSLVEMAV-GRYPIPPPDAKEL 271 + G +M+PE + Y+ +SD+WS G+ L E+ G P P Sbjct: 220 NDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVD-- 277 Query: 272 ELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFS 331 + EG +P Sbjct: 278 SKFYKMIKEGFRMLSPEHA----------------------------------------P 297 Query: 332 LEFQDFVNKCLIKNPAERADLKQLMV 357 E D + C +P +R KQ++ Sbjct: 298 AEMYDIMKTCWDADPLKRPTFKQIVQ 323 >4WUA-A nrPDB Length = 401 Score = 195 bits (496), Expect = 3e-50, Method: Composition-based stats. Identities = 70/373 (18%), Positives = 130/373 (34%), Gaps = 69/373 (18%) Query: 56 QKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIREL 115 K+G+L + + I +LG G+ V+ +A K++ + E+ Sbjct: 31 HLVKIGDLFNGRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVK--SAEHYTETALDEI 88 Query: 116 QVLHEC-----NSPY---IVGFYG----AFYSDGEISICMEHMDGGSLDQVLKKAGR-IP 162 ++L N P +V + + I + E + L ++K + +P Sbjct: 89 RLLKSVRNSDPNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLP 148 Query: 163 EQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVN----------------------- 199 + K+ V++GL YL K +I+H D+KP NIL++ Sbjct: 149 LPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPP 208 Query: 200 --------------------------SRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPE 233 + ++K+ D G + + + TR Y S E Sbjct: 209 PSGSAVSTAPATAGNFLVNPLEPKNAEKLKVKIADLGNAC-WVHKHFTEDIQTRQYRSLE 267 Query: 234 RLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKEL--ELMFGCQVEGDAAETPPRPR 291 L G+ Y+ +DIWS E+A G Y P +E + + + P + Sbjct: 268 VLIGSGYNTPADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLI 327 Query: 292 TPGRPLSSYGMDSRPPMAIFELLDYIVNE--PPPKLPSGVFSLEFQDFVNKCLIKNPAER 349 G+ + I +L + + E S + F DF+ L P +R Sbjct: 328 VAGKYSKEFFTKKGDLKHITKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKR 387 Query: 350 ADLKQLMVHAFIK 362 A + + H ++ Sbjct: 388 ATAAECLRHPWLN 400 >4HZS-A nrPDB Length = 341 Score = 195 bits (495), Expect = 3e-50, Method: Composition-based stats. Identities = 59/264 (22%), Positives = 114/264 (43%), Gaps = 16/264 (6%) Query: 63 LKDDDFEKISELGAGNGGVVFKVSHK-PSGLVM--ARKLIHLEI--KPAIRNQIIRELQV 117 + + D + +LG G+ GVV + PSG + A K + ++ +P + IRE+ Sbjct: 9 IGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNA 68 Query: 118 LHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKA-GRIPEQILGKVSIAVIKG 176 +H + ++ YG + + + E GSL L+K G L + ++ V +G Sbjct: 69 MHSLDHRNLIRLYGVVLTP-PMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEG 127 Query: 177 LTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRS-----YMS 231 + YL K + +HRD+ N+L+ +R +K+ DFG+ L + + + + + Sbjct: 128 MGYLESK-RFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCA 186 Query: 232 PERLQGTHYSVQSDIWSMGLSLVEMAV-GRYPIPPPDAKEL--ELMFGCQVEGDAAETPP 288 PE L+ +S SD W G++L EM G+ P + ++ ++ + + P Sbjct: 187 PESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQ 246 Query: 289 RPRTPGRPLSSYGMDSRPPMAIFE 312 ++ + RP Sbjct: 247 DIYNVMVQCWAHKPEDRPTFVALR 270 >5HIE-A nrPDB Length = 302 Score = 194 bits (494), Expect = 4e-50, Method: Composition-based stats. Identities = 57/284 (20%), Positives = 111/284 (39%), Gaps = 23/284 (8%) Query: 56 QKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIREL 115 E+ D +G+G+ G V+K +A K++ P E+ Sbjct: 26 DSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD---VAVKML----TPQQLQAFKNEV 78 Query: 116 QVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKK-AGRIPEQILGKVSIAVI 174 VL + I+ F G + + +++I + +G SL L + L ++ Sbjct: 79 GVLRKTRHVNILLFMG-YSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTA 137 Query: 175 KGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVS----GQLIDSMANSFVGTRSYM 230 +G+ YL K I+HRD+K +NI ++ +K+ DFG++ G+ +M Sbjct: 138 QGMDYLHAK-SIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWM 196 Query: 231 SPERLQ---GTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQ------VEG 281 +PE ++ YS QSD+++ G+ L E+ G+ P + ++ + + + Sbjct: 197 APEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSK 256 Query: 282 DAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKL 325 + P + D RP ++ PK+ Sbjct: 257 VRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKI 300 >3ZBF-A nrPDB Length = 322 Score = 194 bits (494), Expect = 4e-50, Method: Composition-based stats. Identities = 65/322 (20%), Positives = 118/322 (36%), Gaps = 67/322 (20%) Query: 53 FLTQKQKVGELKDDDFEKISELGAGNGGVVFKVS-----HKPSGLV-MARKLIHLEIKPA 106 F + + + LG+G G V++ + SG + +A K + Sbjct: 20 FQGSIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQ 79 Query: 107 IRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIP---- 162 + + ++E ++ + N P I+ G + I +E M+GG L L+KA Sbjct: 80 EKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGP 139 Query: 163 ---EQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGE-----IKLCDFGVSGQ 214 L + + + KG YL H +HRD+ N LV+ + +K+ DFG++ Sbjct: 140 LLTLVDLVDLCVDISKGCVYLERMH-FIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARD 198 Query: 215 LIDSMANSFVGT----RSYMSPERLQGTHYSVQSDIWSMGLSLVEMAV-GRYPIPPPDAK 269 + + G +M+PE L ++ QSD+WS G+ + E+ G P P Sbjct: 199 IYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSN- 257 Query: 270 ELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGV 329 L+++ Q G EPP P + Sbjct: 258 -LDVLNYVQTGGRL------------------------------------EPPRNCPDDL 280 Query: 330 FSLEFQDFVNKCLIKNPAERAD 351 + + + +C + P +R Sbjct: 281 W-----NLMTQCWAQEPDQRPT 297 >4LRM-A nrPDB Length = 334 Score = 194 bits (494), Expect = 5e-50, Method: Composition-based stats. Identities = 65/280 (23%), Positives = 119/280 (42%), Gaps = 22/280 (7%) Query: 63 LKDDDFEKISELGAGNGGVVFKVSHKPSGLV----MARKLIHLEIKPAIRNQIIRELQVL 118 LK+ +F+KI LG+G G V+K P G +A K + P +I+ E V+ Sbjct: 16 LKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVM 75 Query: 119 HECN---SPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKA-GRIPEQILGKVSIAVI 174 + +P++ G + + + + M G L +++ I Q L + + Sbjct: 76 ASVDNPGNPHVCRLLGICLTST-VQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIA 134 Query: 175 KGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL-IDSMANSFVGTR---SYM 230 KG+ YL ++ +++HRD+ N+LV + +K+ DFG++ L + G + +M Sbjct: 135 KGMNYLEDR-RLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWM 193 Query: 231 SPERLQGTHYSVQSDIWSMGLSLVEMAV-GRYPIPPPDAKELELMFGCQVEGDAAETPPR 289 + E + Y+ QSD+WS G+++ E+ G P A E+ + +G+ PP Sbjct: 194 ALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILE---KGERLPQPPI 250 Query: 290 PRTPGR----PLSSYGMDSRPPMAIFELLDYIVNEPPPKL 325 DSRP + + P + Sbjct: 251 CTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRY 290 >3HMP-A nrPDB Length = 342 Score = 194 bits (493), Expect = 5e-50, Method: Composition-based stats. Identities = 69/313 (22%), Positives = 121/313 (38%), Gaps = 63/313 (20%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIR-ELQVLHECN--SP 124 + + ++G+G VF+V + + A K ++LE R E+ L++ S Sbjct: 58 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 116 Query: 125 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKH 184 I+ Y +D I + ME L+ LKK I +++ + + +H Sbjct: 117 KIIRLYDYEITDQYIYMVME-CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIH-QH 174 Query: 185 KIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA----NSFVGTRSYMSPERLQGTHY 240 I+H D+KP+N L+ G +KL DFG++ Q+ +S VGT +YM PE ++ Sbjct: 175 GIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSS 233 Query: 241 SVQ-----------SDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPR 289 S + SD+WS+G L M G+ P + +L E P Sbjct: 234 SRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPN-HEIEFPDI 292 Query: 290 PRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAER 349 P + QD + CL ++P +R Sbjct: 293 PE----------------------------------------KDLQDVLKCCLKRDPKQR 312 Query: 350 ADLKQLMVHAFIK 362 + +L+ H +++ Sbjct: 313 ISIPELLAHPYVQ 325 >1U54-B nrPDB Length = 291 Score = 193 bits (491), Expect = 9e-50, Method: Composition-based stats. Identities = 59/264 (22%), Positives = 114/264 (43%), Gaps = 16/264 (6%) Query: 63 LKDDDFEKISELGAGNGGVVFKVSHK-PSGLVM--ARKLIHLEI--KPAIRNQIIRELQV 117 + + D + +LG G+ GVV + PSG + A K + ++ +P + IRE+ Sbjct: 15 IGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNA 74 Query: 118 LHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKA-GRIPEQILGKVSIAVIKG 176 +H + ++ YG + + + E GSL L+K G L + ++ V +G Sbjct: 75 MHSLDHRNLIRLYGVVLTP-PMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEG 133 Query: 177 LTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRS-----YMS 231 + YL K + +HRD+ N+L+ +R +K+ DFG+ L + + + + + Sbjct: 134 MGYLESK-RFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCA 192 Query: 232 PERLQGTHYSVQSDIWSMGLSLVEMAV-GRYPIPPPDAKEL--ELMFGCQVEGDAAETPP 288 PE L+ +S SD W G++L EM G+ P + ++ ++ + + P Sbjct: 193 PESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQ 252 Query: 289 RPRTPGRPLSSYGMDSRPPMAIFE 312 ++ + RP Sbjct: 253 DIYNVMVQCWAHKPEDRPTFVALR 276 >2ZMD-A nrPDB Length = 390 Score = 193 bits (491), Expect = 1e-49, Method: Composition-based stats. Identities = 75/351 (21%), Positives = 133/351 (37%), Gaps = 71/351 (20%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIR-ELQVLHECN--SP 124 + + ++G+G VF+V + + A K ++LE R E+ L++ S Sbjct: 58 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 116 Query: 125 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKH 184 I+ Y +D I + ME L+ LKK I +++ + + +H Sbjct: 117 KIIRLYDYEITDQYIYMVME-CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIH-QH 174 Query: 185 KIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA----NSFVGTRSYMSPERLQGTHY 240 I+H D+KP+N L+ G +KL DFG++ Q+ +S VG +YM PE ++ Sbjct: 175 GIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGAVNYMPPEAIKDMSS 233 Query: 241 SVQ-----------SDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPR 289 S + SD+WS+G L M G+ P + +L E P Sbjct: 234 SRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPN-HEIEFPDI 292 Query: 290 PRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAER 349 P + QD + CL ++P +R Sbjct: 293 PE----------------------------------------KDLQDVLKCCLKRDPKQR 312 Query: 350 ADLKQLMVHAFIK-RSDAEEV-------DFAGWLCSTIGLNQPSTPTHAAG 392 + +L+ H +++ ++ + L +GLN P++ AA Sbjct: 313 ISIPELLAHPYVQIQTHPVNQMAKGTTEEMKYVLGQLVGLNSPNSILKAAK 363 >5AP3-A nrPDB Length = 313 Score = 192 bits (489), Expect = 1e-49, Method: Composition-based stats. Identities = 69/313 (22%), Positives = 121/313 (38%), Gaps = 63/313 (20%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIR-ELQVLHECN--SP 124 + + ++G+G VF+V + + A K ++LE R E+ L++ S Sbjct: 30 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 88 Query: 125 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKH 184 I+ Y +D I + ME L+ LKK I +++ + + +H Sbjct: 89 KIIRLYDYEITDQYIYMVME-CGNIDLNGWLKKKKSIDPWERKSYWKNMLEAVHTIH-QH 146 Query: 185 KIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA----NSFVGTRSYMSPERLQGTHY 240 I+H D+KP+N L+ G +KL DFG++ Q+ +S VGT +YM PE ++ Sbjct: 147 GIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSS 205 Query: 241 SVQ-----------SDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPR 289 S + SD+WS+G L M G+ P + +L E P Sbjct: 206 SRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPN-HEIEFPDI 264 Query: 290 PRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAER 349 P + QD + CL ++P +R Sbjct: 265 PE----------------------------------------KDLQDVLKCCLKRDPKQR 284 Query: 350 ADLKQLMVHAFIK 362 + +L+ H +++ Sbjct: 285 ISIPELLAHPYVQ 297 >4YFF-A nrPDB Length = 311 Score = 192 bits (489), Expect = 2e-49, Method: Composition-based stats. Identities = 63/247 (25%), Positives = 109/247 (44%), Gaps = 16/247 (6%) Query: 62 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEI--KPAIRNQIIRELQVLH 119 L+ + E +G+G+ G V+K + ++A K + + RE+ +L Sbjct: 38 HLQLSEIEFHEIIGSGSFGKVYKGRCR--NKIVAIKRYRANTYCSKSDVDMFCREVSILC 95 Query: 120 ECNSPYIVGFYGAFYSDG-EISICMEHMDGGSLDQVLKKAGR-IPEQILGKVSIAVIKGL 177 + N P ++ F GA +D + +I +++ GGSL +L + R + Q +++ V KG+ Sbjct: 96 QLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGM 155 Query: 178 TYLREK-HKIMHRDVKPSNILVNSRGEIKLCDFGVSGQ---LIDSMANSFVGTRSYMSPE 233 YL I+HRD+ NIL+ G + DFG S L + G +M+PE Sbjct: 156 EYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPE 215 Query: 234 RL-QGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRT 292 Q T Y++++D++S L L E+ G P PP + Sbjct: 216 VFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHI-----RPPIGYS 270 Query: 293 PGRPLSS 299 +P+SS Sbjct: 271 IPKPISS 277 >5C26-A nrPDB Length = 299 Score = 192 bits (488), Expect = 2e-49, Method: Composition-based stats. Identities = 63/254 (24%), Positives = 119/254 (46%), Gaps = 16/254 (6%) Query: 72 SELGAGNGGVVFKVSHK-----PSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYI 126 ELG+GN G V K ++ + V K + PA++++++ E V+ + ++PYI Sbjct: 33 KELGSGNFGTVKKGYYQMKKVVKTVAVKILK--NEANDPALKDELLAEANVMQQLDNPYI 90 Query: 127 VGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKI 186 V G ++ + + ME + G L++ L++ + ++ + ++ V G+ YL E + Sbjct: 91 VRMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESN-F 148 Query: 187 MHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGT-----RSYMSPERLQGTHYS 241 +HRD+ N+L+ ++ K+ DFG+S L T + +PE + +S Sbjct: 149 VHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFS 208 Query: 242 VQSDIWSMGLSLVE-MAVGRYPIPPPDAKELELMFGC-QVEGDAAETPPRPRTPGRPLSS 299 +SD+WS G+ + E + G+ P E+ M + G A P + Sbjct: 209 SKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWT 268 Query: 300 YGMDSRPPMAIFEL 313 Y +++RP A EL Sbjct: 269 YDVENRPGFAAVEL 282 >3UIM-A nrPDB Length = 326 Score = 192 bits (487), Expect = 2e-49, Method: Composition-based stats. Identities = 59/287 (20%), Positives = 118/287 (41%), Gaps = 11/287 (3%) Query: 38 EELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARK 97 ++ +E L + ++ D+F + LG G G V+K G ++A K Sbjct: 2 FDVPAEEDPEVHLGQLKRFSLRELQVASDNFSNKNILGRGGFGKVYKGRL-ADGTLVAVK 60 Query: 98 LIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKK 157 + E Q E++++ ++ G + E + +M GS+ L++ Sbjct: 61 RLKEERTQGGELQFQTEVEMISMAVHRNLLRLRGFCMTPTERLLVYPYMANGSVASCLRE 120 Query: 158 A----GRIPEQILGKVSIAVIKGLTYLREKH--KIMHRDVKPSNILVNSRGEIKLCDFGV 211 + ++++ +GL YL + KI+HRDVK +NIL++ E + DFG+ Sbjct: 121 RPESQPPLDWPKRQRIALGSARGLAYLHDHCDPKIIHRDVKAANILLDEEFEAVVGDFGL 180 Query: 212 SGQL---IDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIP-PPD 267 + + + + GT +++PE L S ++D++ G+ L+E+ G+ Sbjct: 181 AKLMDYKDTHVTTAVRGTIGHIAPEYLSTGKSSEKTDVFGYGVMLLELITGQRAFDLARL 240 Query: 268 AKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELL 314 A + ++M V+G E +Y + + LL Sbjct: 241 ANDDDVMLLDWVKGLLKEKKLEALVDVDLQGNYKDEEVEQLIQVALL 287 >1AD5-A nrPDB Length = 438 Score = 191 bits (486), Expect = 3e-49, Method: Composition-based stats. Identities = 55/253 (21%), Positives = 103/253 (40%), Gaps = 18/253 (7%) Query: 57 KQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQ 116 ++ E+ + + +LGAG G V+ ++ +A K + + E Sbjct: 173 EKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTK-VAVKTMKPGSMSV--EAFLAEAN 229 Query: 117 VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLK--KAGRIPEQILGKVSIAVI 174 V+ +V + + I I E M GSL LK + + P L S + Sbjct: 230 VMKTLQHDKLVKLHAVV-TKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIA 288 Query: 175 KGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPER 234 +G+ ++ +++ I HRD++ +NILV++ K+ DFG++ + +PE Sbjct: 289 EGMAFIEQRNYI-HRDLRAANILVSASLVCKIADFGLARVGAKFPIK-------WTAPEA 340 Query: 235 LQGTHYSVQSDIWSMGLSLVEMAV-GRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTP 293 + ++++SD+WS G+ L+E+ GR P P E+ G P Sbjct: 341 INFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEV---IRALERGYRMPRPENCPEE 397 Query: 294 GRPLSSYGMDSRP 306 + +RP Sbjct: 398 LYNIMMRCWKNRP 410 >3AOX-A nrPDB Length = 344 Score = 191 bits (486), Expect = 3e-49, Method: Composition-based stats. Identities = 69/295 (23%), Positives = 111/295 (37%), Gaps = 26/295 (8%) Query: 52 AFLTQKQKVGELKD---DDFEKISELGAGNGGVVFKVS-----HKPSGLVMARKLIHLEI 103 F + + +LK+ + I LG G G V++ + PS L +A K + Sbjct: 30 CFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVC 89 Query: 104 KPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPE 163 + E ++ + N IV G I +E M GG L L++ P Sbjct: 90 SEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPS 149 Query: 164 Q-------ILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRG---EIKLCDFGVSG 213 Q L V+ + G YL E H +HRD+ N L+ G K+ DFG++ Sbjct: 150 QPSSLAMLDLLHVARDIACGCQYLEENH-FIHRDIAARNCLLTCPGPGRVAKIGDFGMAR 208 Query: 214 QLIDSMANSFVGTR----SYMSPERLQGTHYSVQSDIWSMGLSLVEMAV-GRYPIPPPDA 268 + + G +M PE ++ ++D WS G+ L E+ G P P Sbjct: 209 DIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSN 268 Query: 269 KELELMFGCQVEGDAAETPPRPRTPGRP-LSSYGMDSRPPMA-IFELLDYIVNEP 321 +E+ D + P P + + RP A I E ++Y +P Sbjct: 269 QEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDP 323 >4IDT-A nrPDB Length = 356 Score = 191 bits (486), Expect = 4e-49, Method: Composition-based stats. Identities = 76/250 (30%), Positives = 115/250 (46%), Gaps = 31/250 (12%) Query: 62 ELKDDDFEKISE---------LGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQII 112 +LK D+E E LG G+ G V ++ K +G A K + LE+ A Sbjct: 61 KLKPVDYEYREEVHWATHQLRLGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRAE----- 115 Query: 113 RELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIA 172 EL SP IV YGA ++I ME ++GGSL Q++K+ G +PE Sbjct: 116 -ELMACAGLTSPRIVPLYGAVREGPWVNIFMELLEGGSLGQLVKEQGCLPEDRALYYLGQ 174 Query: 173 VIKGLTYLREKHKIMHRDVKPSNILVNSRG-EIKLCDFGVSGQL------IDSMANSFV- 224 ++GL YL + +I+H DVK N+L++S G LCDFG + L D + ++ Sbjct: 175 ALEGLEYLHSR-RILHGDVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKDLLTGDYIP 233 Query: 225 GTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAA 284 GT ++M+PE + G + D+WS ++ M G +P + G A+ Sbjct: 234 GTETHMAPEVVLGRSCDAKVDVWSSCCMMLHMLNGCHPW-------TQFFRGPLCLKIAS 286 Query: 285 ETPPRPRTPG 294 E PP P Sbjct: 287 EPPPVREIPP 296 >1TKI-A nrPDB Length = 321 Score = 191 bits (486), Expect = 4e-49, Method: Composition-based stats. Identities = 58/302 (19%), Positives = 114/302 (37%), Gaps = 47/302 (15%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPY 125 + + +LG G G+V + S K + ++ + + +E+ +L+ Sbjct: 5 EKYMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVKGTDQV--LVKKEISILNIARHRN 62 Query: 126 IVGFYGAFYSDGEISICMEHMDGGSLDQVLK-KAGRIPEQILGKVSIAVIKGLTYLREKH 184 I+ + +F S E+ + E + G + + + A + E+ + V + L +L H Sbjct: 63 ILHLHESFESMEELVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCEALQFLHS-H 121 Query: 185 KIMHRDVKPSNILVNSR--GEIKLCDFGVSGQLIDSMANSFVGT-RSYMSPERLQGTHYS 241 I H D++P NI+ +R IK+ +FG + QL + T Y +PE Q S Sbjct: 122 NIGHFDIRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLFTAPEYYAPEVHQHDVVS 181 Query: 242 VQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYG 301 +D+WS+G + + G P ++ Sbjct: 182 TATDMWSLGTLVYVLLSGINPF-------------------------------LAETNQQ 210 Query: 302 MDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFI 361 + A + + E S+E DFV++ L+K R + + H ++ Sbjct: 211 IIENIMNAEYTFDEEAFKE---------ISIEAMDFVDRLLVKERKSRMTASEALQHPWL 261 Query: 362 KR 363 K+ Sbjct: 262 KQ 263 >5UIU-A nrPDB Length = 323 Score = 191 bits (485), Expect = 5e-49, Method: Composition-based stats. Identities = 63/266 (23%), Positives = 118/266 (44%), Gaps = 19/266 (7%) Query: 72 SELGAGNGGVVFKVSHKPSGLVMARKLIHLEIK---PAIRNQIIRELQVLHECNSPYIVG 128 +++G G GVV+K + +A K + + ++ Q +E++V+ +C +V Sbjct: 53 NKMGEGGFGVVYKGYVNNT--TVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVE 110 Query: 129 FYGAFYSDGEISICMEHMDGGSLDQV---LKKAGRIPEQILGKVSIAVIKGLTYLREKHK 185 G ++ + +M GSL L + + K++ G+ +L E H Sbjct: 111 LLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHH 170 Query: 186 IMHRDVKPSNILVNSRGEIKLCDFGVSG---QLIDSMANSF-VGTRSYMSPERLQGTHYS 241 I HRD+K +NIL++ K+ DFG++ + ++ S VGT +YM+PE L+G + Sbjct: 171 I-HRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEI-T 228 Query: 242 VQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYG 301 +SDI+S G+ L+E+ G + +L L ++E + Sbjct: 229 PKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTI-----EDYIDKKMND 283 Query: 302 MDSRPPMAIFELLDYIVNEPPPKLPS 327 DS A++ + ++E K P Sbjct: 284 ADSTSVEAMYSVASQCLHEKKNKRPD 309 >4NEU-A nrPDB Length = 333 Score = 191 bits (485), Expect = 5e-49, Method: Composition-based stats. Identities = 67/310 (21%), Positives = 123/310 (39%), Gaps = 57/310 (18%) Query: 59 KVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVL 118 V ++K DF + +EL +G G V H+ GL++ + + ++ E +++ Sbjct: 17 NVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMM 76 Query: 119 HECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLT 178 + +V G +G+ S+ ME+M+ G+L VLK P + G++ + +I+G+ Sbjct: 77 NRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMC 136 Query: 179 YLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSG---------------QLIDSMANSF 223 YL K ++H+D+KP NILV++ IK+ D G++ + +D A Sbjct: 137 YLHGK-GVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKN 195 Query: 224 VGTRSYMSPERLQGTHY--SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEG 281 GT YM+PE L + + +SD++S + L + + P +A + + C G Sbjct: 196 GGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYE--NAICEQQLIMCIKSG 253 Query: 282 DAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKC 341 + + R E + C Sbjct: 254 NRPDVDDITEYCPR-------------------------------------EIISLMKLC 276 Query: 342 LIKNPAERAD 351 NP R Sbjct: 277 WEANPEARPT 286 >3OMV-A nrPDB Length = 307 Score = 191 bits (484), Expect = 7e-49, Method: Composition-based stats. Identities = 51/224 (22%), Positives = 102/224 (45%), Gaps = 14/224 (6%) Query: 61 GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHL-EIKPAIRNQIIRELQVLH 119 E++ + + +G+G+ G V+K +A K++ + + P E+ VL Sbjct: 31 WEIEASEVMLSTRIGSGSFGTVYKGKWHGD---VAVKILKVVDPTPEQFQAFRNEVAVLR 87 Query: 120 ECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLK-KAGRIPEQILGKVSIAVIKGLT 178 + I+ F G D ++I + +G SL + L + + L ++ +G+ Sbjct: 88 KTRHVNILLFMGYMTKDN-LAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMD 146 Query: 179 YLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVS----GQLIDSMANSFVGTRSYMSPER 234 YL K+ I+HRD+K +NI ++ +K+ DFG++ G+ +M+PE Sbjct: 147 YLHAKN-IIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEV 205 Query: 235 LQ---GTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMF 275 ++ +S QSD++S G+ L E+ G P + ++ + Sbjct: 206 IRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFM 249 >3DLS-A nrPDB Length = 335 Score = 191 bits (484), Expect = 7e-49, Method: Composition-based stats. Identities = 65/306 (21%), Positives = 109/306 (35%), Gaps = 61/306 (19%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE-------IKPAIRNQIIRELQVLHE 120 + +S LG+G G V+ K + K I E I+ ++ E+ +L Sbjct: 26 YSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSR 85 Query: 121 CNSPYIVGFYGAFYSDGEISICME-HMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTY 179 I+ F + G + ME H G L + + R+ E + + ++ + Y Sbjct: 86 VEHANIIKVLDIFENQGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASYIFRQLVSAVGY 145 Query: 180 LREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA-NSFVGTRSYMSPERLQGT 238 LR K I+HRD+K NI++ IKL DFG + L +F GT Y +PE L G Sbjct: 146 LRLK-DIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGN 204 Query: 239 HY-SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPL 297 Y + ++WS+G++L + P Sbjct: 205 PYRGPELEMWSLGVTLYTLVFEENPF------------------------------CELE 234 Query: 298 SSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMV 357 + PP + S E V+ L P R L++L+ Sbjct: 235 ETVEAAIHPPY--------------------LVSKELMSLVSGLLQPVPERRTTLEKLVT 274 Query: 358 HAFIKR 363 ++ + Sbjct: 275 DPWVTQ 280 >5LPZ-A nrPDB Length = 332 Score = 190 bits (483), Expect = 8e-49, Method: Composition-based stats. Identities = 55/210 (26%), Positives = 97/210 (46%), Gaps = 12/210 (5%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIV 127 F S +G+G G V+K K G +A K + + + + + E++ + + +V Sbjct: 19 FHNDSLIGSGGFGDVYKAILK-DGSAVAIKKL-IHVSGQGDREFMAEMETIGKIKHRNLV 76 Query: 128 GFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR----IPEQILGKVSIAVIKGLTYLREK 183 G E + E M GSL+ VL + + K++I +GL +L Sbjct: 77 PLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHHN 136 Query: 184 HK--IMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMAN----SFVGTRSYMSPERLQG 237 I+HRD+K SN+L++ E ++ DFG++ + + + GT Y+ PE Q Sbjct: 137 CSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYYQS 196 Query: 238 THYSVQSDIWSMGLSLVEMAVGRYPIPPPD 267 S + D++S G+ L+E+ G+ P PD Sbjct: 197 FRCSTKGDVYSYGVVLLELLTGKRPTDSPD 226 >5LPV-A nrPDB Length = 296 Score = 190 bits (482), Expect = 1e-48, Method: Composition-based stats. Identities = 55/210 (26%), Positives = 97/210 (46%), Gaps = 12/210 (5%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIV 127 F S +G+G G V+K K G +A K + + + + + E++ + + +V Sbjct: 19 FHNDSLIGSGGFGDVYKAILK-DGSAVAIKKL-IHVSGQGDREFMAEMETIGKIKHRNLV 76 Query: 128 GFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR----IPEQILGKVSIAVIKGLTYLREK 183 G E + E M GSL+ VL + + K++I +GL +L Sbjct: 77 PLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHHN 136 Query: 184 HK--IMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMAN----SFVGTRSYMSPERLQG 237 I+HRD+K SN+L++ E ++ DFG++ + + + GT Y+ PE Q Sbjct: 137 CSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYYQS 196 Query: 238 THYSVQSDIWSMGLSLVEMAVGRYPIPPPD 267 S + D++S G+ L+E+ G+ P PD Sbjct: 197 FRCSTKGDVYSYGVVLLELLTGKRPTDSPD 226 >5HLW-A nrPDB Length = 299 Score = 189 bits (480), Expect = 2e-48, Method: Composition-based stats. Identities = 52/251 (20%), Positives = 105/251 (41%), Gaps = 14/251 (5%) Query: 72 SELGAGNGGVVFKVS---HKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVG 128 +G G+ G V+ + + + A K ++ +Q + E ++ + + P ++ Sbjct: 26 EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLS 85 Query: 129 FYGAFY-SDGEISICMEHMDGGSLDQVLKKAGRIP-EQILGKVSIAVIKGLTYLREKHKI 186 G S+G + + +M G L ++ P + L + V KG+ YL K K Sbjct: 86 LLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASK-KF 144 Query: 187 MHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSF---VGTR---SYMSPERLQGTHY 240 +HRD+ N +++ + +K+ DFG++ + D S G + +M+ E LQ + Sbjct: 145 VHRDLAARNCMLDEKFTVKVADFGLARDMHDKEYYSVHNKTGAKLPVKWMALESLQTQKF 204 Query: 241 SVQSDIWSMGLSLVEMAV-GRYPIPPPDAKELEL-MFGCQVEGDAAETPPRPRTPGRPLS 298 + +SD+WS G+ L E+ G P P + ++ + + + P Sbjct: 205 TTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCW 264 Query: 299 SYGMDSRPPMA 309 + RP + Sbjct: 265 HPKAEMRPSFS 275 >4G3E-A nrPDB Length = 352 Score = 189 bits (479), Expect = 2e-48, Method: Composition-based stats. Identities = 79/274 (28%), Positives = 128/274 (46%), Gaps = 37/274 (13%) Query: 7 TPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELKDD 66 + A +++ T S+ + KL+ L + + + + LT+K LK Sbjct: 19 GSVSSGQAHSLASLAKTWSSGS------AKLQRLGPETEDNEGV--LLTEK-----LKPV 65 Query: 67 DFEKISEL---------GAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQV 117 D+E E+ G G+ G V ++ K +G A K + LE+ + EL Sbjct: 66 DYEYREEVHWMTHQPRVGRGSFGEVHRMKDKQTGFQCAVKKVRLEVFR------VEELVA 119 Query: 118 LHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGL 177 +SP IV YGA ++I ME ++GGSL Q++K+ G +PE ++GL Sbjct: 120 CAGLSSPRIVPLYGAVREGPWVNIFMELLEGGSLGQLIKQMGCLPEDRALYYLGQALEGL 179 Query: 178 TYLREKHKIMHRDVKPSNILVNSRG-EIKLCDFGVSGQL-IDSMANSFV------GTRSY 229 YL + +I+H DVK N+L++S G LCDFG + L D + S + GT ++ Sbjct: 180 EYLHTR-RILHGDVKADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETH 238 Query: 230 MSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPI 263 M+PE + G + DIWS ++ M G +P Sbjct: 239 MAPEVVMGKPCDAKVDIWSSCCMMLHMLNGCHPW 272 >6B2Q-A nrPDB Length = 317 Score = 188 bits (477), Expect = 4e-48, Method: Composition-based stats. Identities = 59/238 (24%), Positives = 102/238 (42%), Gaps = 11/238 (4%) Query: 51 EAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE--IKPAIR 108 L +VG + + G G V++ G +A K++ E P Sbjct: 17 RGSLHMSPRVGVTLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFI 76 Query: 109 NQIIRELQVLHECNSPYI--VGFYGAFYSDGE---ISICMEHMDGGSLDQVLKKAGRIPE 163 + E + N P I V YG +GE + ME ++G L+ VLK+ GR+ Sbjct: 77 ERFRAEARTTAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSL 136 Query: 164 QILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID---SMA 220 + + + L + ++HRDVKP NIL+ G++K+ DFG++ + + Sbjct: 137 RHALDMLEQTGRALQ-IAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQT 195 Query: 221 NSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQ 278 +GT Y++PE+ G S SD++S+G+ E G+ P A + + + Sbjct: 196 GMVMGTAQYIAPEQALGHDASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKE 253 >3PLS-A nrPDB Length = 298 Score = 188 bits (477), Expect = 4e-48, Method: Composition-based stats. Identities = 58/283 (20%), Positives = 109/283 (38%), Gaps = 20/283 (7%) Query: 42 LDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKP---SGLVMARKL 98 LD ++ L ++V D +G G+ GVV+ + + + A K Sbjct: 3 LDSALLAEVKDVLIPHERVVTHSD------RVIGKGHFGVVYHGEYIDQAQNRIQCAIKS 56 Query: 99 IHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEI-SICMEHMDGGSLDQVLKK 157 + + +RE ++ N P ++ G + + + +M G L Q ++ Sbjct: 57 LSRITEMQQVEAFLREGLLMRGLNHPNVLALIGIMLPPEGLPHVLLPYMCHGDLLQFIRS 116 Query: 158 AGRIP-EQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLI 216 R P + L + V +G+ YL E+ K +HRD+ N +++ +K+ DFG++ ++ Sbjct: 117 PQRNPTVKDLISFGLQVARGMEYLAEQ-KFVHRDLAARNCMLDESFTVKVADFGLARDIL 175 Query: 217 DSMANSFVGTR------SYMSPERLQGTHYSVQSDIWSMGLSLVEMAV-GRYPIPPPDAK 269 D S R + + E LQ ++ +SD+WS G+ L E+ G P D Sbjct: 176 DREYYSVQQHRHARLPVKWTALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPF 235 Query: 270 ELELMFG-CQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIF 311 +L + P + RP + Sbjct: 236 DLTHFLAQGRRLPQPEYCPDSLYQVMQQCWEADPAVRPTFRVL 278 >2JD5-A nrPDB Length = 373 Score = 188 bits (477), Expect = 4e-48, Method: Composition-based stats. Identities = 72/333 (21%), Positives = 132/333 (39%), Gaps = 33/333 (9%) Query: 64 KDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNS 123 KD + + +LG G+ V+ + +A K++ + E+++L N Sbjct: 17 KDARYILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVRGD--KVYTEAAEDEIKLLQRVND 74 Query: 124 -----------PYIVGFYGAFYSDG----EISICMEHMDGGSLDQVLKKAGR--IPEQIL 166 +I+ F G + + E + G +L ++KK IP + Sbjct: 75 ADNTKEDSMGANHILKLLDHFNHKGPNGVHVVMVFE-VLGENLLALIKKYEHRGIPLIYV 133 Query: 167 GKVSIAVIKGLTYLREKHKIMHRDVKPSNILVN------SRGEIKLCDFGVSGQLIDSMA 220 ++S ++ GL Y+ + I+H D+KP N+L+ + +IK+ D G + D Sbjct: 134 KQISKQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNACWY-DEHY 192 Query: 221 NSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELEL--MFGCQ 278 + + TR Y SPE L G + +DIWS + E+ G + P + Q Sbjct: 193 TNSIQTREYRSPEVLLGAPWGCGADIWSTACLIFELITGDFLFEPDEGHSYTKDDDHIAQ 252 Query: 279 VEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQ--- 335 + E P G+ ++ +SR + L + E E + Sbjct: 253 IIELLGELPSYLLRNGKYTRTF-FNSRGLLRNISKLKFWPLEDVLTEKYKFSKDEAKEIS 311 Query: 336 DFVNKCLIKNPAERADLKQLMVHAFIKRSDAEE 368 DF++ L +P +RAD L+ H ++K + E Sbjct: 312 DFLSPMLQLDPRKRADAGGLVNHPWLKDTLGME 344 >4X3F-A nrPDB Length = 337 Score = 187 bits (476), Expect = 5e-48, Method: Composition-based stats. Identities = 58/230 (25%), Positives = 101/230 (43%), Gaps = 11/230 (4%) Query: 59 KVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE--IKPAIRNQIIRELQ 116 +VG + + G G V++ G +A K++ E P + E + Sbjct: 5 RVGVTLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEAR 64 Query: 117 VLHECNSPYI--VGFYGAFYSDGE---ISICMEHMDGGSLDQVLKKAGRIPEQILGKVSI 171 N P I V YG +GE + ME ++G L+ VLK+ GR+ + + Sbjct: 65 TTAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLE 124 Query: 172 AVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID---SMANSFVGTRS 228 + L + ++HRDVKP NIL+ G++K+ DFG++ + + +GT Sbjct: 125 QTGRALQ-IAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQ 183 Query: 229 YMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQ 278 Y++PE+ G S SD++S+G+ E G+ P A + + + Sbjct: 184 YIAPEQALGHDASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKE 233 >4OW8-A nrPDB Length = 283 Score = 187 bits (476), Expect = 5e-48, Method: Composition-based stats. Identities = 58/230 (25%), Positives = 101/230 (43%), Gaps = 11/230 (4%) Query: 59 KVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE--IKPAIRNQIIRELQ 116 +VG + + G G V++ G +A K++ E P + E + Sbjct: 4 RVGVTLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEAR 63 Query: 117 VLHECNSPYI--VGFYGAFYSDGE---ISICMEHMDGGSLDQVLKKAGRIPEQILGKVSI 171 N P I V YG +GE + ME ++G L+ VLK+ GR+ + + Sbjct: 64 TTAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLE 123 Query: 172 AVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID---SMANSFVGTRS 228 + L + ++HRDVKP NIL+ G++K+ DFG++ + + +GT Sbjct: 124 QTGRALQ-IAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQ 182 Query: 229 YMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQ 278 Y++PE+ G S SD++S+G+ E G+ P A + + + Sbjct: 183 YIAPEQALGHDASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKE 232 >6HMD-A nrPDB Length = 365 Score = 187 bits (475), Expect = 6e-48, Method: Composition-based stats. Identities = 60/304 (19%), Positives = 117/304 (38%), Gaps = 20/304 (6%) Query: 64 KDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNS 123 DD++ + +LG G VF+ + + ++ +KP + +I RE+++L Sbjct: 51 NQDDYQLVRKLGRGKYSEVFEAINITNNER----VVVKILKPVKKKKIKREVKILENLRG 106 Query: 124 P-YIVGFYGAFYSD--GEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL 180 I+ ++ E+++ Q+ + + + ++K L Y Sbjct: 107 GTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQL---YQILTDFDIRFYMYELLKALDYC 163 Query: 181 REKHKIMHRDVKPSNILVNSR-GEIKLCDFGVSGQLIDSM-ANSFVGTRSYMSPERL-QG 237 K IMHRDVKP N++++ + +++L D+G++ + N V +R + PE L Sbjct: 164 HSK-GIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDY 222 Query: 238 THYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPL 297 Y D+WS+G L M R P +L+ +V G + Sbjct: 223 QMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYH---- 278 Query: 298 SSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMV 357 +D + + + S E D ++K L + +R K+ M Sbjct: 279 --IDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAME 336 Query: 358 HAFI 361 H + Sbjct: 337 HPYF 340 >3C1X-A nrPDB Length = 373 Score = 187 bits (475), Expect = 7e-48, Method: Composition-based stats. Identities = 51/251 (20%), Positives = 106/251 (42%), Gaps = 14/251 (5%) Query: 72 SELGAGNGGVVFKVS---HKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVG 128 +G G+ G V+ + + + A K ++ +Q + E ++ + + P ++ Sbjct: 95 EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLS 154 Query: 129 FYGAFY-SDGEISICMEHMDGGSLDQVLKKAGRIP-EQILGKVSIAVIKGLTYLREKHKI 186 G S+G + + +M G L ++ P + L + V KG+ +L K K Sbjct: 155 LLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKFLASK-KF 213 Query: 187 MHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSF---VGTR---SYMSPERLQGTHY 240 +HRD+ N +++ + +K+ DFG++ + D +S G + +M+ E LQ + Sbjct: 214 VHRDLAARNCMLDEKFTVKVADFGLARDMYDKEFDSVHNKTGAKLPVKWMALESLQTQKF 273 Query: 241 SVQSDIWSMGLSLVEMAV-GRYPIPPPDAKELEL-MFGCQVEGDAAETPPRPRTPGRPLS 298 + +SD+WS G+ L E+ G P P + ++ + + + P Sbjct: 274 TTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCW 333 Query: 299 SYGMDSRPPMA 309 + RP + Sbjct: 334 HPKAEMRPSFS 344 >3LLT-A nrPDB Length = 360 Score = 187 bits (475), Expect = 8e-48, Method: Composition-based stats. Identities = 75/338 (22%), Positives = 126/338 (37%), Gaps = 39/338 (11%) Query: 59 KVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVL 118 K G L ++ F I ++G G G V H + A K++ IK R+ I E +L Sbjct: 28 KKGMLLNNAFLVIRKMGDGTFGRVLLCQHIDNKKYYAVKVVR-NIKKYTRSAKI-EADIL 85 Query: 119 HECNSPYI-----VGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR--IPEQILGKVSI 171 + + I V ++G F + + E + G SL +++ + + + I Sbjct: 86 KKIQNDDINNNNIVKYHGKFMYYDHMCLIFEPL-GPSLYEIITRNNYNGFHIEDIKLYCI 144 Query: 172 AVIKGLTYLREKHKIMHRDVKPSNILVNSRGE-------------------------IKL 206 ++K L YLR K + H D+KP NIL++ IKL Sbjct: 145 EILKALNYLR-KMSLTHTDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRTKSTGIKL 203 Query: 207 CDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPP 266 DFG + D S + TR Y +PE + + V SD+WS G L E+ G Sbjct: 204 IDFGCATFKSDYHG-SIINTRQYRAPEVILNLGWDVSSDMWSFGCVLAELYTGSLLFRTH 262 Query: 267 DAKELELMFGCQVE--GDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPK 324 + E M ++ + ++ + P + + Sbjct: 263 EHMEHLAMMESIIQPIPKNMLYEATKTNGSKYVNKDELKLAWPENASSINSIKHVKKCLP 322 Query: 325 LPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIK 362 L + F DF+ L +P R +L+ H F++ Sbjct: 323 LYKIIKHELFCDFLYSILQIDPTLRPSPAELLKHKFLE 360 >2A1A-B nrPDB Length = 284 Score = 187 bits (474), Expect = 8e-48, Method: Composition-based stats. Identities = 57/210 (27%), Positives = 102/210 (48%), Gaps = 25/210 (11%) Query: 67 DFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYI 126 DF++I +G+G G VFK H+ G K + + A R E++ L + + I Sbjct: 12 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAER-----EVKALAKLDHVNI 66 Query: 127 VGFYGAF----------------YSDGEISICMEHMDGGSLDQVL--KKAGRIPEQILGK 168 V + G + + I ME D G+L+Q + ++ ++ + + + Sbjct: 67 VHYNGCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALE 126 Query: 169 VSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLI-DSMANSFVGTR 227 + + KG+ Y+ K K+++RD+KPSNI + ++K+ DFG+ L D GT Sbjct: 127 LFEQITKGVDYIHSK-KLINRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTL 185 Query: 228 SYMSPERLQGTHYSVQSDIWSMGLSLVEMA 257 YMSPE++ Y + D++++GL L E+ Sbjct: 186 RYMSPEQISSQDYGKEVDLYALGLILAELL 215 >4MD7-E nrPDB Length = 391 Score = 187 bits (474), Expect = 9e-48, Method: Composition-based stats. Identities = 61/304 (20%), Positives = 116/304 (38%), Gaps = 20/304 (6%) Query: 64 KDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNS 123 DD++ + +LG G VF+ + + ++ +KP + +I RE+++L Sbjct: 35 NQDDYQLVRKLGRGKYSEVFEAINITNNEK----VVVKILKPVKKKKIKREIKILENLRG 90 Query: 124 -PYIVGFYGAFYSD--GEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL 180 P I+ ++ EH++ Q+ + + + ++K L Y Sbjct: 91 GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQL---YQTLTDYDIRFYMYEILKALDYC 147 Query: 181 REKHKIMHRDVKPSNILVNSRG-EIKLCDFGVSGQLI-DSMANSFVGTRSYMSPERL-QG 237 IMHRDVKP N++++ +++L D+G++ N V +R + PE L Sbjct: 148 HSM-GIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDY 206 Query: 238 THYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPL 297 Y D+WS+G L M + P +L+ +V G + Sbjct: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKY----- 261 Query: 298 SSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMV 357 + +D R + + S E DF++K L + R ++ M Sbjct: 262 -NIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAME 320 Query: 358 HAFI 361 H + Sbjct: 321 HPYF 324 >1ZXE-A nrPDB Length = 303 Score = 187 bits (474), Expect = 9e-48, Method: Composition-based stats. Identities = 66/334 (19%), Positives = 123/334 (36%), Gaps = 76/334 (22%) Query: 67 DFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYI 126 DFE+I+ LG G G V K + A K I + I+ E+ +L N Y+ Sbjct: 7 DFEEIAVLGQGAFGQVVKARNALDSRYYAIKKIR--HTEEKLSTILSEVMLLASLNHQYV 64 Query: 127 VGFYGAFYS-------------DGEISICMEHMDGGSLDQVLKKAG-RIPEQILGKVSIA 172 V +Y A+ + I ME+ + +L ++ ++ Sbjct: 65 VRYYAAWLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQRDEYWRLFRQ 124 Query: 173 VIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLI---------------- 216 +++ L+Y+ + I+HR++KP NI ++ +K+ DFG++ + Sbjct: 125 ILEALSYIHSQ-GIIHRNLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKLDSQNLPGS 183 Query: 217 DSMANSFVGTRSYMSPERLQGT-HYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMF 275 S +GT Y++ E L GT HY+ + D++S+G+ EM YP Sbjct: 184 SDNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMI---YPFSTG--------- 231 Query: 276 GCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQ 335 + I + L + E PP +E + Sbjct: 232 -----------------------------MERVNILKKLRSVSIEFPPDFDDNKMKVE-K 261 Query: 336 DFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEV 369 + + +P +R + L+ ++ +EV Sbjct: 262 KIIRLLIDHDPNKRPGARTLLNSGWLPVKHQDEV 295 >4RC3-A nrPDB Length = 289 Score = 186 bits (473), Expect = 1e-47, Method: Composition-based stats. Identities = 61/319 (19%), Positives = 117/319 (36%), Gaps = 61/319 (19%) Query: 55 TQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRN----- 109 K E + ++ LG+G G V+ L +A K + + Sbjct: 1 GPHMKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGT 60 Query: 110 QIIRELQVLHECNSPY--IVGFYGAFYSDGEISICMEHMDGG-SLDQVLKKAGRIPEQIL 166 ++ E+ +L + +S + ++ F + +E + L + + G + E++ Sbjct: 61 RVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELA 120 Query: 167 GKVSIAVIKGLTYLREKHKIMHRDVKPSNILVN-SRGEIKLCDFGVSGQLIDSMANSFVG 225 V++ + + ++HRD+K NIL++ +RGE+KL DFG L D++ F G Sbjct: 121 RSFFWQVLEAVRHCHN-CGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDG 179 Query: 226 TRSYMSPERLQGTHY-SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAA 284 TR Y PE ++ Y + +WS+G+ L +M G P + +F Q Sbjct: 180 TRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQ------ 233 Query: 285 ETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIK 344 S E Q + CL Sbjct: 234 --------------------------------------------RVSSECQHLIRWCLAL 249 Query: 345 NPAERADLKQLMVHAFIKR 363 P++R +++ H +++ Sbjct: 250 RPSDRPTFEEIQNHPWMQD 268 >5XVU-A nrPDB Length = 332 Score = 186 bits (472), Expect = 1e-47, Method: Composition-based stats. Identities = 71/314 (22%), Positives = 120/314 (38%), Gaps = 28/314 (8%) Query: 64 KDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNS 123 K + +E + ++G G VF A +KP + +I RE+++L N Sbjct: 29 KPNRYEIMKKIGRGKYSEVFNGYDTECNRPCA----IKVLKPVKKKKIKREIKILQNLNG 84 Query: 124 -PYIVGFYGAFYSD--GEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL 180 P I+ S+ E+++ + + ++ + ++K L Y Sbjct: 85 GPNIIKLLDIVKDPVTKTPSLIFEYINNIDFKTL---YPKFTDKDIRYYIYQILKALDYC 141 Query: 181 REKHKIMHRDVKPSNILVN-SRGEIKLCDFGVSGQLI-DSMANSFVGTRSYMSPERLQG- 237 + IMHRDVKP NI+++ +I+L +G++ N V +R Y PE L Sbjct: 142 HSQ-GIMHRDVKPHNIMIDHENRQIRLISWGLAEFYHPGQEYNVRVASRYYKGPELLIDL 200 Query: 238 THYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEG----DAAETPPRPRTP 293 Y DIWS+G L M + P +L+ +V G A + Sbjct: 201 QLYDYSLDIWSLGCMLAGMIFKKEPFFCGHDNYDQLVKIAKVLGTEDLHAYLKKYNIKLK 260 Query: 294 GRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLK 353 L+ G R P + F I + E D ++K LI + A+R K Sbjct: 261 PHYLNILGEYERKPWSHFLTQSNI----------DIAKDEVIDLIDKMLIYDHAKRIAPK 310 Query: 354 QLMVHAFIKRSDAE 367 + M H + + E Sbjct: 311 EAMEHPYFREVREE 324 >5WNL-A nrPDB Length = 342 Score = 186 bits (472), Expect = 2e-47, Method: Composition-based stats. Identities = 60/298 (20%), Positives = 122/298 (40%), Gaps = 48/298 (16%) Query: 67 DFEKISELGAGNGGVVFKVSHKPSGLVMARKLI-HLEIKPAIRNQIIRELQVLHECNSPY 125 +F ++G+G G V+KV H +A K L + R +++ E + + Y Sbjct: 21 EFAGWEKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRERMELLEEAKKMEMAKFRY 80 Query: 126 IVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHK 185 I+ YG + + ME+M+ GSL+++L + +P + ++ G+ +L Sbjct: 81 ILPVYGICQE--PVGLVMEYMETGSLEKLL-ASEPLPWDLRFRIVHETAVGMNFLHCMSP 137 Query: 186 -IMHRDVKPSNILVNSRGEIKLCDFGVSG-----QLIDSMANSFVGTRSYMSPERLQGTH 239 ++H ++KP+NIL+++ +K+ DFG++ D + GT +Y+ PER++ Sbjct: 138 PLLHLNLKPANILLDAHYHVKISDFGLAKCNGMSHSHDLSMDGLFGTIAYLPPERIREKS 197 Query: 240 --YSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPL 297 + + D++S + + + + P D K + + V+G E PP R R Sbjct: 198 RLFDTKHDVYSFAIVIWGVLTQKKPF--ADEKNILHIMMKVVKGHRPELPPICRPRPRAC 255 Query: 298 SSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQL 355 +S + +C +P R +++ Sbjct: 256 AS----------------------------------LIGLMQRCWHADPQVRPTFQEI 279 >3BGP-A nrPDB Length = 333 Score = 186 bits (471), Expect = 2e-47, Method: Composition-based stats. Identities = 67/342 (19%), Positives = 124/342 (36%), Gaps = 62/342 (18%) Query: 33 LQKKLEELE-LDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSG 91 L K+ L L L A K E + ++ LG+G G V+ Sbjct: 22 LLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDN 81 Query: 92 LVMARKLIHLEIKPAIRN-----QIIRELQVLHECNSPY--IVGFYGAFYSDGEISICME 144 L +A K + + ++ E+ +L + +S + ++ F + +E Sbjct: 82 LPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILE 141 Query: 145 HMDGG-SLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVN-SRG 202 + L + + G + E++ V++ + + ++HRD+K NIL++ +RG Sbjct: 142 RPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHN-CGVLHRDIKDENILIDLNRG 200 Query: 203 EIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY-SVQSDIWSMGLSLVEMAVGRY 261 E+KL DFG L D++ F GTR Y PE ++ Y + +WS+G+ L +M G Sbjct: 201 ELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDI 260 Query: 262 PIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEP 321 P + +F Q Sbjct: 261 PFEHDEEIIRGQVFFRQ------------------------------------------- 277 Query: 322 PPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKR 363 S E Q + CL P++R +++ H +++ Sbjct: 278 -------RVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQD 312 >6EII-A nrPDB Length = 352 Score = 185 bits (470), Expect = 3e-47, Method: Composition-based stats. Identities = 61/304 (20%), Positives = 116/304 (38%), Gaps = 20/304 (6%) Query: 64 KDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNS 123 DD++ + +LG G VF+ + + ++ +KP + +I RE+++L Sbjct: 58 NQDDYQLVRKLGRGKYSEVFEAINITNNEK----VVVKILKPVKKKKIKREIKILENLRG 113 Query: 124 -PYIVGFYGAFYSD--GEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL 180 P I+ ++ EH++ Q+ + + + ++K L Y Sbjct: 114 GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQL---YQTLTDYDIRFYMYEILKALDYC 170 Query: 181 REKHKIMHRDVKPSNILVNSRG-EIKLCDFGVSGQLI-DSMANSFVGTRSYMSPERL-QG 237 IMHRDVKP N++++ +++L D+G++ N V +R + PE L Sbjct: 171 HSM-GIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDY 229 Query: 238 THYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPL 297 Y D+WS+G L M + P +L+ +V G + Sbjct: 230 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKY----- 284 Query: 298 SSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMV 357 + +D R + + S E DF++K L + R ++ M Sbjct: 285 -NIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAME 343 Query: 358 HAFI 361 H + Sbjct: 344 HPYF 347 >6J5U-C nrPDB Length = 426 Score = 184 bits (468), Expect = 4e-47, Method: Composition-based stats. Identities = 73/313 (23%), Positives = 131/313 (41%), Gaps = 45/313 (14%) Query: 62 ELKD--DDFEKISELGAGNGGVVFK---------VSHKPSGLVMARKLIHLEIKPAIRNQ 110 ELK+ +F + + LG G G VFK S SG+V+A K + E + Sbjct: 78 ELKNATKNFRQDNLLGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQLKPEGFQG-HKE 136 Query: 111 IIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAG--RIPEQILGK 168 + E+ L + + P +V G + E M GSL+ L + G + I K Sbjct: 137 WLTEVNYLGQLSHPNLVLLVGYCAEGENRLLVYEFMPKGSLENHLFRRGAQPLTWAIRMK 196 Query: 169 VSIAVIKGLTYLRE-KHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID----SMANSF 223 V++ KGLT+L E K ++++RD K +NIL+++ KL DFG++ ++ Sbjct: 197 VAVGAAKGLTFLHEAKSQVIYRDFKAANILLDADFNAKLSDFGLAKAGPTGDNTHVSTKV 256 Query: 224 VGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDA 283 +GT Y +PE + + +SD++S G+ L+E+ GR + + Sbjct: 257 IGTHGYAAPEYVATGRLTAKSDVYSFGVVLLELISGRRAMDNSNG--------------- 301 Query: 284 AETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLI 343 + + Y D R +F ++D + P + + +CL Sbjct: 302 ----GNEYSLVDWATPYLGDKRK---LFRIMDTKLGGQYP----QKGAFTAANLALQCLN 350 Query: 344 KNPAERADLKQLM 356 + R + +++ Sbjct: 351 PDAKLRPKMSEVL 363 >5TUR-A nrPDB Length = 404 Score = 184 bits (468), Expect = 4e-47, Method: Composition-based stats. Identities = 67/342 (19%), Positives = 124/342 (36%), Gaps = 62/342 (18%) Query: 33 LQKKLEELE-LDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSG 91 L K+ L L L A K E + ++ LG+G G V+ Sbjct: 93 LLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDN 152 Query: 92 LVMARKLIHLEIKPAIRN-----QIIRELQVLHECNSPY--IVGFYGAFYSDGEISICME 144 L +A K + + ++ E+ +L + +S + ++ F + +E Sbjct: 153 LPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILE 212 Query: 145 HMDGG-SLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVN-SRG 202 + L + + G + E++ V++ + + ++HRD+K NIL++ +RG Sbjct: 213 RPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHN-CGVLHRDIKDENILIDLNRG 271 Query: 203 EIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY-SVQSDIWSMGLSLVEMAVGRY 261 E+KL DFG L D++ F GTR Y PE ++ Y + +WS+G+ L +M G Sbjct: 272 ELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDI 331 Query: 262 PIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEP 321 P + +F Q Sbjct: 332 PFEHDEEIIRGQVFFRQ------------------------------------------- 348 Query: 322 PPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKR 363 S E Q + CL P++R +++ H +++ Sbjct: 349 -------RVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQD 383 >3ZZW-A nrPDB Length = 289 Score = 184 bits (466), Expect = 7e-47, Method: Composition-based stats. Identities = 54/278 (19%), Positives = 101/278 (36%), Gaps = 31/278 (11%) Query: 61 GELKDDDF---EKISELGAGNGGVVFKVSH-----KPSGLVMARKLIHLEIKPAIRNQII 112 G+LK+ + ELG G V+K +A K + + + +R + Sbjct: 1 GKLKEISLSAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFR 60 Query: 113 RELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR------------ 160 E + P +V G D +S+ + G L + L Sbjct: 61 HEAMLRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRT 120 Query: 161 ----IPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLI 216 + + + G+ YL H ++H+D+ N+LV + +K+ D G+ ++ Sbjct: 121 VKSALEPPDFVHLVAQIAAGMEYL-SSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVY 179 Query: 217 DSMANSFVGT----RSYMSPERLQGTHYSVQSDIWSMGLSLVE-MAVGRYPIPPPDAKE- 270 + +G +M+PE + +S+ SDIWS G+ L E + G P ++ Sbjct: 180 AADYYKLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDV 239 Query: 271 LELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPM 308 +E++ QV + P + RP Sbjct: 240 VEMIRNRQVLPCPDDCPAWVYALMIECWNEFPSRRPRF 277 >3UIU-A nrPDB Length = 306 Score = 182 bits (461), Expect = 3e-46, Method: Composition-based stats. Identities = 57/223 (25%), Positives = 102/223 (45%), Gaps = 38/223 (17%) Query: 67 DFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYI 126 DF++I +G+G G VFK H+ G + + + A R E++ L + + I Sbjct: 13 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIRRVKYNNEKAER-----EVKALAKLDHVNI 67 Query: 127 VGFYGAF-----------------------------YSDGEISICMEHMDGGSLDQVL-- 155 V + G + + I ME D G+L+Q + Sbjct: 68 VHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEK 127 Query: 156 KKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL 215 ++ ++ + + ++ + KG+ Y+ K K++HRD+KPSNI + ++K+ DFG+ L Sbjct: 128 RRGEKLDKVLALELFEQITKGVDYIHSK-KLIHRDLKPSNIFLVDTKQVKIGDFGLVTSL 186 Query: 216 I-DSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMA 257 D GT YMSPE++ Y + D++++GL L E+ Sbjct: 187 KNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELL 229 >4Y83-A nrPDB Length = 332 Score = 179 bits (455), Expect = 1e-45, Method: Composition-based stats. Identities = 71/286 (24%), Positives = 114/286 (39%), Gaps = 47/286 (16%) Query: 76 AGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYS 135 G G V+ + MA KLI ++ +++ I YGA Sbjct: 83 RGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSD------VEIQACFRHENIAELYGAVLW 136 Query: 136 DGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSN 195 + + ME +GGS+ + L+ G + E + V+ V+KGL +L K K++H D+KPSN Sbjct: 137 GETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKGLDFLHSK-KVIHHDIKPSN 195 Query: 196 ILVNSRGEIKLCDFGVSGQLIDSMA--NSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSL 253 I+ S + L DFG+S Q+ + + GT YMSPE + +S ++DI+S+G +L Sbjct: 196 IVFMSTKAV-LVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILCRGHSTKADIYSLGATL 254 Query: 254 VEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFEL 313 + M G P + PR P L Sbjct: 255 IHMQTGTPPW--------------------VKRYPRSAYPSY-----------------L 277 Query: 314 LDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHA 359 PP + + S ++ + L +NP R L+ H Sbjct: 278 YIIHKQAPPLEDIADDCSPGMRELIEASLERNPNHRPRAADLLKHE 323 >5XD6-A nrPDB Length = 305 Score = 178 bits (451), Expect = 4e-45, Method: Composition-based stats. Identities = 55/215 (25%), Positives = 93/215 (43%), Gaps = 18/215 (8%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPY 125 D++ S +G G+ G VF K SG A K + +P + + ++ ++ Sbjct: 22 DNYGSKSLIGEGSYGRVFYGILK-SGKAAAIKKLDSSKQPD--QEFLAQVSMVSRLRQEN 78 Query: 126 IVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAG---------RIPEQILGKVSIAVIKG 176 +V G + E+ GSL +L + K+++ +G Sbjct: 79 VVALLGYCVDGPLRVLAYEYAPNGSLHDILHGRKGVKGAQPGPVLSWHQRVKIAVGAARG 138 Query: 177 LTYLREKHK--IMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS----MANSFVGTRSYM 230 L YL EK ++HRD+K SN+L+ K+ DF +S Q D + +GT Y Sbjct: 139 LEYLHEKANPHVIHRDIKSSNVLLFDDDVAKIADFDLSNQAPDMAARLHSTRVLGTFGYH 198 Query: 231 SPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPP 265 +PE S +SD++S G+ L+E+ GR P+ Sbjct: 199 APEYAMTGTLSTKSDVYSFGVVLLELLTGRKPVDH 233 >4X7Q-B nrPDB Length = 312 Score = 178 bits (451), Expect = 4e-45, Method: Composition-based stats. Identities = 66/321 (20%), Positives = 113/321 (35%), Gaps = 66/321 (20%) Query: 62 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEI----KPAIRNQII-RELQ 116 E + ++ LG G G VF L +A K+I P + E+ Sbjct: 27 EAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVA 86 Query: 117 VLHECN----SPYIVGFYGAFYSDGEISICME-HMDGGSLDQVLKKAGRIPEQILGKVSI 171 +L + P ++ F + + +E + L + + G + E Sbjct: 87 LLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFG 146 Query: 172 AVIKGLTYLREKHKIMHRDVKPSNILVN-SRGEIKLCDFGVSGQLIDSMANSFVGTRSYM 230 V+ + + + ++HRD+K NIL++ RG KL DFG L D F GTR Y Sbjct: 147 QVVAAIQHCHSR-GVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTRVYS 205 Query: 231 SPERLQGTHYSV-QSDIWSMGLSLVEMAVGRYPIP-PPDAKELELMFGCQVEGDAAETPP 288 PE + Y + +WS+G+ L +M G P + E EL F V Sbjct: 206 PPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEILEAELHFPAHV--------- 256 Query: 289 RPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAE 348 S + + +CL P+ Sbjct: 257 ------------------------------------------SPDCCALIRRCLAPKPSS 274 Query: 349 RADLKQLMVHAFIKRSDAEEV 369 R L+++++ + ++ AE+V Sbjct: 275 RPSLEEILLDPW-MQTPAEDV 294 >4C59-A nrPDB Length = 340 Score = 178 bits (451), Expect = 4e-45, Method: Composition-based stats. Identities = 69/336 (20%), Positives = 117/336 (34%), Gaps = 81/336 (24%) Query: 52 AFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQI 111 F+ Q ++GEL L G V++ SG A K + L + I Sbjct: 16 DFVGQTVELGEL---RLRVRRVLAEGGFAFVYEAQDVGSGREYALKRL-LSNEEEKNRAI 71 Query: 112 IRELQVLHECN-SPYIVGF-----YGAFYSDG---EISICMEHMDGGSLDQVLKK---AG 159 I+E+ + + + P IV F G SD E + E G L + LKK G Sbjct: 72 IQEVCFMKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELC-KGQLVEFLKKMESRG 130 Query: 160 RIPEQILGKVSIAVIKGLTYLR-EKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS 218 + + K+ + + ++ +K I+HRD+K N+L++++G IKLCDFG + + Sbjct: 131 PLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHY 190 Query: 219 MANSFVG--------------TRSYMSPERL-QGTHY--SVQSDIWSMGLSLVEMAVGRY 261 S+ T Y +PE + +++ + DIW++G L + ++ Sbjct: 191 PDYSWSAQRRALVEEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQH 250 Query: 262 PIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEP 321 P IVN Sbjct: 251 PFEDG----------------------------------------------AKLRIVNGK 264 Query: 322 PPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMV 357 P F + L NP ER + +++ Sbjct: 265 YSIPPHDTQYTVFHSLIRAMLQVNPEERLSIAEVVH 300 >5WNO-A nrPDB Length = 330 Score = 177 bits (449), Expect = 7e-45, Method: Composition-based stats. Identities = 53/284 (18%), Positives = 99/284 (34%), Gaps = 21/284 (7%) Query: 69 EKISELGAGNGGVVFKVSH-----KPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNS 123 + +LGAG G VF + K + +A K+ + + ++++ E + Sbjct: 25 KLDKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVF--QTDQSQTDEMLEEATNMFRLRH 82 Query: 124 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLK-KAGRIPEQILGKVSIAVIKGLTYLRE 182 ++ G D + I + G+L LK + + + G+ YL E Sbjct: 83 DNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKENLGAREQVLYCYQIASGMQYL-E 141 Query: 183 KHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS----MANSFVGTRSYMSPERLQGT 238 K +++HRD+ N+LV +++ DFG+S L S +++ E Sbjct: 142 KQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIEIFSKH 201 Query: 239 HYSVQSDIWSMGLSLVEMAV-GRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRP- 296 Y+ SD+W+ G++ E+ G+ P + +G+ PP Sbjct: 202 CYTHASDVWAFGVTCWEIITFGQSPYQGMSTDS---IHNFLKDGNRLSQPPNCSQDLYQE 258 Query: 297 ---LSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDF 337 SRP I + P + D Sbjct: 259 LLRCWMADPKSRPGFEILYERFKEFCKVPQLFLENSNKISESDL 302 >4CRL-A nrPDB Length = 406 Score = 177 bits (448), Expect = 1e-44, Method: Composition-based stats. Identities = 70/354 (19%), Positives = 124/354 (35%), Gaps = 46/354 (12%) Query: 52 AFLTQKQKVGELKDDDFEKIS-ELGAGNGGVVFKVSHKPSGLV--MARKLIHLEIKPAIR 108 F + E +D FE ++G G G V+K K A K I I Sbjct: 7 DFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQIE---GTGIS 63 Query: 109 NQIIRELQVLHECNSPYIVGFYGAFYS--DGEISICMEHMDGGSLDQVLK---------K 157 RE+ +L E P ++ F S D ++ + ++ + L ++K K Sbjct: 64 MSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEH-DLWHIIKFHRASKANKK 122 Query: 158 AGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVN----SRGEIKLCDFGVSG 213 ++P ++ + ++ G+ YL + ++HRD+KP+NILV RG +K+ D G + Sbjct: 123 PVQLPRGMVKSLLYQILDGIHYLH-ANWVLHRDLKPANILVMGEGPERGRVKIADMGFAR 181 Query: 214 QLIDSMA-----NSFVGTRSYMSPERLQG-THYSVQSDIWSMGLSLVEMAVGRYPIP--- 264 + + V T Y +PE L G HY+ DIW++G E+ Sbjct: 182 LFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQ 241 Query: 265 -------PPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYI 317 P +L+ +F + + P + Sbjct: 242 EDIKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYME 301 Query: 318 VNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDF 371 ++ P + + K L +P +R +Q M + D Sbjct: 302 KHKVKP-------DSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLEDPLPTSDV 348 >2WTK-C nrPDB Length = 305 Score = 176 bits (447), Expect = 1e-44, Method: Composition-based stats. Identities = 66/312 (21%), Positives = 119/312 (38%), Gaps = 59/312 (18%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIK---PAIRNQIIRELQVLHECNSP 124 + LG G+ G V +V + A K++ + P + +E+Q+L Sbjct: 7 YLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHK 66 Query: 125 YIVGFYGAFYSDGE--ISICMEHMDGGSLDQVLKK--AGRIPEQILGKVSIAVIKGLTYL 180 ++ Y++ + + + ME+ G + ++L R P +I GL YL Sbjct: 67 NVIQLVDVLYNEEKQKMYMVMEYCVCG-MQEMLDSVPEKRFPVCQAHGYFCQLIDGLEYL 125 Query: 181 REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLI----DSMANSFVGTRSYMSPERLQ 236 + I+H+D+KP N+L+ + G +K+ GV+ L D + G+ ++ PE Sbjct: 126 HSQ-GIVHKDIKPGNLLLTTGGTLKISALGVAEALHPFAADDTCRTSQGSPAFQPPEIAN 184 Query: 237 G--THYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPG 294 G T + DIWS G++L + G YP + +F +G A P G Sbjct: 185 GLDTFSGFKVDIWSAGVTLYNITTGLYPFEG---DNIYKLFENIGKGSYA----IPGDCG 237 Query: 295 RPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQ 354 PLS D + L PA+R ++Q Sbjct: 238 PPLS-------------------------------------DLLKGMLEYEPAKRFSIRQ 260 Query: 355 LMVHAFIKRSDA 366 + H++ ++ Sbjct: 261 IRQHSWFRKKHP 272 >4JLC-A nrPDB Length = 657 Score = 176 bits (445), Expect = 2e-44, Method: Composition-based stats. Identities = 74/318 (23%), Positives = 124/318 (38%), Gaps = 30/318 (9%) Query: 72 SELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYG 131 LG G VF+ HK +G + A K+ + + +RE +VL + N IV + Sbjct: 14 DILGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFA 73 Query: 132 AFYSDG--EISICMEHMDGGSLDQVLKK---AGRIPEQILGKVSIAVIKGLTYLREKHKI 186 + ME GSL VL++ A +PE V V+ G+ +LRE + I Sbjct: 74 IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE-NGI 132 Query: 187 MHRDVKPSNIL--VNSRGE--IKLCDFGVSGQLIDS-MANSFVGTRSYMSPERLQG---- 237 +HRD+KP NI+ + G+ KL DFG + +L D S GT Y+ P+ + Sbjct: 133 VHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLR 192 Query: 238 ----THYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEG----------DA 283 Y D+WS+G++ A G P P + ++ Sbjct: 193 KDHQKKYGATVDLWSVGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQK 252 Query: 284 AETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKC-L 342 AE P + PLS + L + + + F E D +++ + Sbjct: 253 AENGPIDWSGDMPLSCSLSQGLQALLTPVLANILEADQEKCWGFDQFFAETSDVLHRMVI 312 Query: 343 IKNPAERADLKQLMVHAF 360 + ++ +H++ Sbjct: 313 HVFSLQHMTAHKIYIHSY 330 >5U6C-A nrPDB Length = 315 Score = 176 bits (445), Expect = 2e-44, Method: Composition-based stats. Identities = 55/303 (18%), Positives = 107/303 (35%), Gaps = 32/303 (10%) Query: 43 DEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKP---SGLVMARKLI 99 E+ + +LE + + + LG G G V + + K + L +A K + Sbjct: 21 SEELQNKLEDVV--------IDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTM 72 Query: 100 HLEIKPAIR-NQIIRELQVLHECNSPYIVGFYGAFYSDGEI-----SICMEHMDGGSLDQ 153 L+ + + E + + + P ++ G + + M G L Sbjct: 73 KLDNSSQREIEEFLSEAACMKDFSHPNVMRLLGVCIEMSSQGIPKPMVILPFMKYGDLHT 132 Query: 154 VL------KKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLC 207 L IP Q L K + + G+ YL ++ +HRD+ N ++ + + Sbjct: 133 YLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRN-FLHRDLAARNCMLRDDMTVCVA 191 Query: 208 DFGVSGQLIDSMANSFVGTR-----SYMSPERLQGTHYSVQSDIWSMGLSLVEMAV-GRY 261 DFG+S ++ G +++ E L Y+ +SD+W+ G+++ E+A G Sbjct: 192 DFGLSKKIYSGDYY-RQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMT 250 Query: 262 PIPPPDAKELE-LMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNE 320 P P E+ + + RP ++ L + E Sbjct: 251 PYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLE 310 Query: 321 PPP 323 P Sbjct: 311 SLP 313 >4EUT-A nrPDB Length = 396 Score = 176 bits (445), Expect = 2e-44, Method: Composition-based stats. Identities = 72/318 (22%), Positives = 125/318 (39%), Gaps = 30/318 (9%) Query: 72 SELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYG 131 LG G VF+ HK +G + A K+ + + +RE +VL + N IV + Sbjct: 15 DILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFA 74 Query: 132 AFYSDG--EISICMEHMDGGSLDQVLKK---AGRIPEQILGKVSIAVIKGLTYLREKHKI 186 + ME GSL VL++ A +PE V V+ G+ +LRE + I Sbjct: 75 IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE-NGI 133 Query: 187 MHRDVKPSNIL--VNSRGE--IKLCDFGVSGQLIDS-MANSFVGTRSYMSPERLQG---- 237 +HR++KP NI+ + G+ KL DFG + +L D S GT Y+ P+ + Sbjct: 134 VHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLR 193 Query: 238 ----THYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEG----------DA 283 Y D+WS+G++ A G P P + ++ Sbjct: 194 KDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQK 253 Query: 284 AETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKC-L 342 AE P + P+S + L + + + F E D +++ + Sbjct: 254 AENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFAETSDILHRMVI 313 Query: 343 IKNPAERADLKQLMVHAF 360 ++ ++ +H++ Sbjct: 314 HVFSLQQMTAHKIYIHSY 331 >4EUU-A nrPDB Length = 319 Score = 174 bits (441), Expect = 6e-44, Method: Composition-based stats. Identities = 62/215 (28%), Positives = 96/215 (44%), Gaps = 19/215 (8%) Query: 72 SELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYG 131 LG G VF+ HK +G + A K+ + + +RE +VL + N IV + Sbjct: 15 DILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFA 74 Query: 132 AFYSDG--EISICMEHMDGGSLDQVLKK---AGRIPEQILGKVSIAVIKGLTYLREKHKI 186 + ME GSL VL++ A +PE V V+ G+ +LRE + I Sbjct: 75 IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE-NGI 133 Query: 187 MHRDVKPSNIL--VNSRGE--IKLCDFGVSGQLIDS-MANSFVGTRSYMSPERLQG---- 237 +HR++KP NI+ + G+ KL DFG + +L D S GT Y+ P+ + Sbjct: 134 VHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLR 193 Query: 238 ----THYSVQSDIWSMGLSLVEMAVGRYPIPPPDA 268 Y D+WS+G++ A G P P + Sbjct: 194 KDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEG 228 >2H34-A nrPDB Length = 309 Score = 174 bits (440), Expect = 8e-44, Method: Composition-based stats. Identities = 54/228 (23%), Positives = 94/228 (41%), Gaps = 6/228 (2%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIH--LEIKPAIRNQIIRELQVLHECNSPY 125 + +G G G V++ ++A KL+ L P R ++ RE + P+ Sbjct: 36 YRLRRLVGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPVFRTRMQREARTAGRLQEPH 95 Query: 126 IVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHK 185 +V + DG++ + M ++G L +L++ G + + + L Sbjct: 96 VVPIHDFGEIDGQLYVDMRLINGVDLAAMLRRQGPLAPPRAVAIVRQIGSALD-AAHAAG 154 Query: 186 IMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMAN---SFVGTRSYMSPERLQGTHYSV 242 HRDVKP NILV++ L DFG++ D + VGT YM+PER +H + Sbjct: 155 ATHRDVKPENILVSADDFAYLVDFGIASATTDEKLTQLGNTVGTLYYMAPERFSESHATY 214 Query: 243 QSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRP 290 ++DI+++ L E G P + + + P P Sbjct: 215 RADIYALTCVLYECLTGSPPYQGDQLSVMGAHINQAIPRPSTVRPGIP 262 >5VD3-A nrPDB Length = 311 Score = 173 bits (439), Expect = 9e-44, Method: Composition-based stats. Identities = 74/301 (24%), Positives = 124/301 (41%), Gaps = 54/301 (17%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIK-PAIRNQIIRELQVLHEC-NSPY 125 F+++S LG G+ G VFKV K G + A K + P R + + E+ + P Sbjct: 59 FQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPC 118 Query: 126 IVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAG-RIPEQILGKVSIAVIKGLTYLREKH 184 V A+ G + + E G SL Q + G +PE + + L +L + Sbjct: 119 CVRLEQAWEEGGILYLQTELC-GPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQ- 176 Query: 185 KIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFV-GTRSYMSPERLQGTHYSVQ 243 ++H DVKP+NI + RG KL DFG+ +L + A G YM+PE LQG+ Y Sbjct: 177 GLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGS-YGTA 235 Query: 244 SDIWSMGLSLVEMAVG-RYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGM 302 +D++S+GL+++E+A P ++L + Sbjct: 236 ADVFSLGLTILEVACNMELPHGGEGWQQLRQGYL-------------------------- 269 Query: 303 DSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIK 362 PP+ +G+ S E + + L +P RA + L+ ++ Sbjct: 270 -------------------PPEFTAGL-SSELRSVLVMMLEPDPKLRATAEALLALPVLR 309 Query: 363 R 363 + Sbjct: 310 Q 310 >3MDY-A nrPDB Length = 337 Score = 173 bits (439), Expect = 1e-43, Method: Composition-based stats. Identities = 68/307 (22%), Positives = 115/307 (37%), Gaps = 46/307 (14%) Query: 67 DFEKISELGAGNGGVVFKVSHKPSGLVMARKLI--HLEIKPAIRNQIIRELQVLHECNSP 124 + + ++G G G V+ + G +A K+ E +I + + + HE Sbjct: 38 QIQMVKQIGKGRYGEVWMGKWR--GEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILG 95 Query: 125 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLRE-- 182 +I S ++ + ++ + GSL LK + + + K++ + + GL +L Sbjct: 96 FIAADIKGTGSWTQLYLITDYHENGSLYDYLKST-TLDAKSMLKLAYSSVSGLCHLHTEI 154 Query: 183 -----KHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL------IDSMANSFVGTRSYMS 231 K I HRD+K NILV G + D G++ + +D N+ VGT+ YM Sbjct: 155 FSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMP 214 Query: 232 PERLQGT------HYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAE 285 PE L + + +D++S GL L E+A V G E Sbjct: 215 PEVLDESLNRNHFQSYIMADMYSFGLILWEVARRC------------------VSGGIVE 256 Query: 286 TPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKN 345 P P D R + I +L P + S + + +C N Sbjct: 257 EYQLPYHDLVPSDPSYEDMREIVCIKKLRP----SFPNRWSSDECLRQMGKLMTECWAHN 312 Query: 346 PAERADL 352 PA R Sbjct: 313 PASRLTA 319 >2QKW-B nrPDB Length = 321 Score = 173 bits (438), Expect = 1e-43, Method: Composition-based stats. Identities = 66/291 (22%), Positives = 122/291 (41%), Gaps = 13/291 (4%) Query: 53 FLTQKQKVGELKD--DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQ 110 F + + + +L++ ++F+ +G G G V+K + G +A K E I Sbjct: 24 FESYRVPLVDLEEATNNFDHKFLIGHGVFGKVYKGVLR-DGAKVALKRRTPESSQGIEEF 82 Query: 111 IIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAG----RIPEQIL 166 ++ L C P++V G E+ + ++M+ G+L + L + + + Sbjct: 83 ETE-IETLSFCRHPHLVSLIGFCDERNEMILIYKYMENGNLKRHLYGSDLPTMSMSWEQR 141 Query: 167 GKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSG---QLIDSMANSF 223 ++ I +GL YL + I+HRDVK NIL++ K+ DFG+S +L + ++ Sbjct: 142 LEICIGAARGLHYLHTR-AIIHRDVKSINILLDENFVPKITDFGISKKGTELDQTHLSTV 200 Query: 224 V-GTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGD 282 V GT Y+ PE + +SD++S G+ L E+ R I +E+ + VE Sbjct: 201 VKGTLGYIDPEYFIKGRLTEKSDVYSFGVVLFEVLCARSAIVQSLPREMVNLAEWAVESH 260 Query: 283 AAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLE 333 + P R + +E P + ++ LE Sbjct: 261 NNGQLEQIVDPNLADKIRPESLRKFGDTAVKCLALSSEDRPSMGDVLWKLE 311 >6O8B-A nrPDB Length = 665 Score = 172 bits (437), Expect = 2e-43, Method: Composition-based stats. Identities = 71/318 (22%), Positives = 124/318 (38%), Gaps = 30/318 (9%) Query: 72 SELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYG 131 LG G VF+ HK +G + A K+ + + +RE +VL + N IV + Sbjct: 21 DILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFA 80 Query: 132 AFYSDG--EISICMEHMDGGSLDQVLKK---AGRIPEQILGKVSIAVIKGLTYLREKHKI 186 + ME GSL VL++ A +PE V V+ G+ +LRE + I Sbjct: 81 IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE-NGI 139 Query: 187 MHRDVKPSNIL--VNSRGE--IKLCDFGVSGQLIDS-MANSFVGTRSYMSPERLQG---- 237 +HR++KP NI+ + G+ KL DFG + +L D GT Y+ P+ + Sbjct: 140 VHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVELYGTEEYLHPDMYERAVLR 199 Query: 238 ----THYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEG----------DA 283 Y D+WS+G++ A G P P + ++ Sbjct: 200 KDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQK 259 Query: 284 AETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKC-L 342 AE P + P+S + L + + + F E D +++ + Sbjct: 260 AENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFAETSDILHRMVI 319 Query: 343 IKNPAERADLKQLMVHAF 360 ++ ++ +H++ Sbjct: 320 HVFSLQQMTAHKIYIHSY 337 >3LMG-A nrPDB Length = 344 Score = 172 bits (436), Expect = 2e-43, Method: Composition-based stats. Identities = 57/274 (20%), Positives = 109/274 (39%), Gaps = 13/274 (4%) Query: 63 LKDDDFEKISELGAGNGGVVFKVSHKPSGL----VMARKLIHLEIKPAIRNQIIRELQVL 118 K+ + K+ LG+G G V K P G + K+I + + + + Sbjct: 28 FKETELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAI 87 Query: 119 HECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLK-KAGRIPEQILGKVSIAVIKGL 177 + +IV G + + +++ GSL ++ G + Q+L + + KG+ Sbjct: 88 GSLDHAHIVRLLGLC-PGSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGM 146 Query: 178 TYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS---MANSFVGTR-SYMSPE 233 YL E H ++HR++ N+L+ S ++++ DFGV+ L + S T +M+ E Sbjct: 147 YYLEE-HGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALE 205 Query: 234 RLQGTHYSVQSDIWSMGLSLVEMAV-GRYPIPPPDAKEL-ELMFGCQVEGDAAETPPRPR 291 + Y+ QSD+WS G+++ E+ G P E+ +L+ + Sbjct: 206 SIHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVY 265 Query: 292 TPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKL 325 + RP + PP+ Sbjct: 266 MVMVKCWMIDENIRPTFKELANEFTRMARDPPRY 299 >6NT9-A nrPDB Length = 742 Score = 172 bits (436), Expect = 2e-43, Method: Composition-based stats. Identities = 72/318 (22%), Positives = 125/318 (39%), Gaps = 30/318 (9%) Query: 72 SELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYG 131 LG G VF+ HK +G + A K+ + + +RE +VL + N IV + Sbjct: 13 DILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFA 72 Query: 132 AFYSDG--EISICMEHMDGGSLDQVLKK---AGRIPEQILGKVSIAVIKGLTYLREKHKI 186 + ME GSL VL++ A +PE V V+ G+ +LRE + I Sbjct: 73 IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE-NGI 131 Query: 187 MHRDVKPSNIL--VNSRGE--IKLCDFGVSGQLIDS-MANSFVGTRSYMSPERLQG---- 237 +HR++KP NI+ + G+ KL DFG + +L D S GT Y+ P+ + Sbjct: 132 VHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLR 191 Query: 238 ----THYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEG----------DA 283 Y D+WS+G++ A G P P + ++ Sbjct: 192 KDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQK 251 Query: 284 AETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKC-L 342 AE P + P+S + L + + + F E D +++ + Sbjct: 252 AENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFAETSDILHRMVI 311 Query: 343 IKNPAERADLKQLMVHAF 360 ++ ++ +H++ Sbjct: 312 HVFSLQQMTAHKIYIHSY 329 >4LFI-A nrPDB Length = 374 Score = 172 bits (435), Expect = 3e-43, Method: Composition-based stats. Identities = 66/345 (19%), Positives = 120/345 (34%), Gaps = 56/345 (16%) Query: 61 GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMAR------------------------ 96 D+E +++G G VF+ S + + Sbjct: 35 WSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNE 94 Query: 97 KL----IHLEIKPAIRNQIIRELQVLH-------ECNSPYIVGFYGAFYSD--GEISICM 143 K+ + + NQ L+ + I+ + ++ Sbjct: 95 KVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVF 154 Query: 144 EHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNS-RG 202 E++D ++L ++ + + ++K L Y IMHRDVKP N++++ Sbjct: 155 EYVDNVD-FRIL--YPKLTDLEIRFYMFELLKALDYCHSM-GIMHRDVKPHNVMIDHKNK 210 Query: 203 EIKLCDFGVSGQL-IDSMANSFVGTRSYMSPERL-QGTHYSVQSDIWSMGLSLVEMAVGR 260 +++L D+G++ ++ N V +R + PE L Y D+WS G L M R Sbjct: 211 KLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKR 270 Query: 261 YPIPPPDAKELELMFGCQVEGDA-AETPPRPRTPGRPLSSYGMDS--RPPMAIFELLDYI 317 P + +L+ +V G + E P Y MD R P F Sbjct: 271 EPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRF------ 324 Query: 318 VNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIK 362 +N+ L + E D ++ L + ER K+ M H + Sbjct: 325 INDGNKHLSG---NDEIIDLIDNLLRYDHQERLTAKEAMGHPWFA 366 >3Q4U-A nrPDB Length = 301 Score = 170 bits (430), Expect = 1e-42, Method: Composition-based stats. Identities = 69/310 (22%), Positives = 109/310 (35%), Gaps = 52/310 (16%) Query: 67 DFEKISELGAGNGGVVFKVSHKPSGLVMARKLI-HLEIKPAIRNQIIRELQVLHECNSPY 125 D + +G G G V++ S + G +A K+ + K R EL Sbjct: 9 DITLLECVGKGRYGEVWRGSWQ--GENVAVKIFSSRDEKSWFRE---TELYNTVMLRHEN 63 Query: 126 IVGFYGAFYSDGE----ISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLR 181 I+GF + + + + + + GSL L+ L + +++ GL +L Sbjct: 64 ILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLR-IVLSIASGLAHLH 122 Query: 182 -------EKHKIMHRDVKPSNILVNSRGEIKLCDFGVS------GQLIDSMANSFVGTRS 228 K I HRD+K NILV G+ + D G++ +D N VGT+ Sbjct: 123 IEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKR 182 Query: 229 YMSPERLQGT------HYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGD 282 YM+PE L T + DIW+ GL L E+A ++ VE Sbjct: 183 YMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVAR-------------RMVSNGIVED- 228 Query: 283 AAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCL 342 PP S M +D P + S + +C Sbjct: 229 --YKPPFYDVVP------NDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECW 280 Query: 343 IKNPAERADL 352 +NP+ R Sbjct: 281 YQNPSARLTA 290 >5E8V-A nrPDB Length = 316 Score = 167 bits (422), Expect = 8e-42, Method: Composition-based stats. Identities = 75/317 (23%), Positives = 124/317 (39%), Gaps = 49/317 (15%) Query: 61 GELKDDD---FEKISELGAGNGGVVFKVSHKPSG----LVMARKLIHLE--IKPAIRNQI 111 G + + + E + +G G V+K K + +A K+ E I Sbjct: 1 GHMHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDI 60 Query: 112 IRELQVLHECNSPYIVGFYGAFYSDGEI----SICMEHMDGGSLDQVLKKAGRIPEQILG 167 ++ I+ F A E+ + G+L + L + I + L Sbjct: 61 FSDIN----LKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRH-VISWEDLR 115 Query: 168 KVSIAVIKGLTYLREKH--------KIMHRDVKPSNILVNSRGEIKLCDFGVSGQL---- 215 K+ ++ +G+ +L H I+HRD+K SNILV + LCDFG+S +L Sbjct: 116 KLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTL 175 Query: 216 -IDSMANS-FVGTRSYMSPER------LQGTHYSVQSDIWSMGLSLVEMAVGRYPI---- 263 +D +ANS VGT YM+PE L+ Q+D++SM L L EM + Sbjct: 176 SVDDLANSGQVGTARYMAPEVLASAMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVK 235 Query: 264 ---PPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNE 320 PP +K E + + RP P L+ G+ M L + ++ Sbjct: 236 DYEPPFGSKVREHPCVASMADNVLADAGRPEIPSFWLNHQGIQ----MVCETLTECWDHD 291 Query: 321 PPPKLPSGVFSLEFQDF 337 P +L + + F + Sbjct: 292 PEARLTAQCVAERFSEL 308 >6BFN-A nrPDB Length = 342 Score = 166 bits (421), Expect = 1e-41, Method: Composition-based stats. Identities = 60/308 (19%), Positives = 117/308 (37%), Gaps = 23/308 (7%) Query: 67 DFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIK---PAIRNQIIRELQVLHECNS 123 +F + ++G G G V++ + + V A K + A++ + E++ L Sbjct: 23 NFSEELKIGEGGFGCVYRAVMRNT--VYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRH 80 Query: 124 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLK----KAGRIPEQILGKVSIAVIKGLTY 179 P IV F G +G + + GSL+ L + + + + + + Sbjct: 81 PNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQF 140 Query: 180 LRE-KHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQ-----------LIDSMANSFVGTR 227 L + ++H D+K SN+L++ R KL DFG++ + + + GT Sbjct: 141 LHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTL 200 Query: 228 SYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETP 287 +Y+ E ++ +V +D +S G+ ++E G+ + A+ L VE +A E Sbjct: 201 AYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQRAVKTHGARTKYL--KDLVEEEAEEAG 258 Query: 288 PRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPA 347 R+ L + I + +P P L CL + Sbjct: 259 VALRSTQSTLQAGLAADAWAAPIAMQIYKKHLDPRPGPCPPELGLGLGQLACCCLHRRAK 318 Query: 348 ERADLKQL 355 R + Q+ Sbjct: 319 RRPPMTQV 326 >5AR8-A nrPDB Length = 326 Score = 165 bits (417), Expect = 3e-41, Method: Composition-based stats. Identities = 68/295 (23%), Positives = 120/295 (40%), Gaps = 36/295 (12%) Query: 71 ISELGAGNGGVVFKVSHKPSGLVMARKL--IHLEIKPAIRNQIIRELQVLHECNSPYIVG 128 + L G G V H + +A K IH + + R ++RE ++LH+ YI+ Sbjct: 37 LRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILP 96 Query: 129 FYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIP---EQILGKVSIAVIKGLTYLREK-H 184 G + I E+M GSL+++L + P + ++ + G+ YL Sbjct: 97 ILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTP 156 Query: 185 KIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFV-------GTRSYMSPERL-- 235 ++H D+K NIL+++ +K+ DFG+S + S++ S GT YM PE Sbjct: 157 PLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEP 216 Query: 236 -QGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPG 294 Q + S++ DI+S + E+ + P L++M+ + P Sbjct: 217 GQKSRASIKHDIYSYAVITWEVLSRKQPFEDV-TNPLQIMYSV-----SQGHRPVINEES 270 Query: 295 RPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAER 349 P Y + R M L++ + P + PS F+ + P R Sbjct: 271 LP---YDIPHRARM--ISLIESGWAQNPDERPS---------FLKCLIELEPVLR 311 >3G2F-A nrPDB Length = 336 Score = 165 bits (417), Expect = 4e-41, Method: Composition-based stats. Identities = 67/320 (20%), Positives = 115/320 (35%), Gaps = 51/320 (15%) Query: 63 LKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQ--IIRELQVLHE 120 L D+ + + +G G G V+K S +A K+ + N+ I R + H+ Sbjct: 10 LDLDNLKLLELIGRGRYGAVYKGS--LDERPVAVKVFSFANRQNFINEKNIYRVPLMEHD 67 Query: 121 CNSPYIVGFYGAFYSDG-EISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTY 179 + +IVG E + ME+ GSL + L +++ +V +GL Y Sbjct: 68 NIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTS-DWVSSCRLAHSVTRGLAY 126 Query: 180 LRE--------KHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLI----------DSMAN 221 L K I HRD+ N+LV + G + DFG+S +L D+ A Sbjct: 127 LHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPGEEDNAAI 186 Query: 222 SFVGTRSYMSPERLQG-------THYSVQSDIWSMGLSLVEMAVGRY-PIPPPDAKELEL 273 S VGT YM+PE L+G Q D++++GL E+ + P E ++ Sbjct: 187 SEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVPEYQM 246 Query: 274 MFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLE 333 F +V + P + + Sbjct: 247 AFQTEVGNHPTFE-------------------DMQVLVSREKQRPKFPEAWKENSLAVRS 287 Query: 334 FQDFVNKCLIKNPAERADLK 353 ++ + C ++ R + Sbjct: 288 LKETIEDCWDQDAEARLTAQ 307 >3MY0-A nrPDB Length = 305 Score = 164 bits (416), Expect = 4e-41, Method: Composition-based stats. Identities = 60/306 (19%), Positives = 106/306 (34%), Gaps = 50/306 (16%) Query: 70 KISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGF 129 + +G G G V++ G +A K+ + + + E+ I+GF Sbjct: 12 LVECVGKGRYGEVWRGLW--HGESVAVKIFSSRDEQSWFRE--TEIYNTVLLRHDNILGF 67 Query: 130 YGAFYS----DGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLR---- 181 + + ++ + + + GSL L++ + + +++++ GL +L Sbjct: 68 IASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQ-TLEPHLALRLAVSAACGLAHLHVEIF 126 Query: 182 ---EKHKIMHRDVKPSNILVNSRGEIKLCDFGVS------GQLIDSMANSFVGTRSYMSP 232 K I HRD K N+LV S + + D G++ +D N VGT+ YM+P Sbjct: 127 GTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAP 186 Query: 233 ERLQGT------HYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAET 286 E L +DIW+ GL L E+A V G + Sbjct: 187 EVLDEQIRTDCFESYKWTDIWAFGLVLWEIAR-----------------RTIVNGIVEDY 229 Query: 287 PPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNP 346 P S M +D P +L + + +C NP Sbjct: 230 RP-----PFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNP 284 Query: 347 AERADL 352 + R Sbjct: 285 SARLTA 290 >1PY5-A nrPDB Length = 326 Score = 164 bits (414), Expect = 8e-41, Method: Composition-based stats. Identities = 60/276 (21%), Positives = 106/276 (38%), Gaps = 34/276 (12%) Query: 72 SELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLH--ECNSPYIVGF 129 +G G G V++ + G +A K+ RE ++ I+GF Sbjct: 35 ESIGKGRFGEVWRGKWR--GEEVAVKI----FSSREERSWFREAEIYQTVMLRHENILGF 88 Query: 130 YGAFYSDG----EISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLR---- 181 A D ++ + ++ + GSL L + + + + K++++ GL +L Sbjct: 89 IAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRY-TVTVEGMIKLALSTASGLAHLHMEIV 147 Query: 182 ---EKHKIMHRDVKPSNILVNSRGEIKLCDFGV------SGQLIDSMANSFVGTRSYMSP 232 K I HRD+K NILV G + D G+ + ID N VGT+ YM+P Sbjct: 148 GTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAP 207 Query: 233 ERLQGT------HYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAET 286 E L + ++DI++MGL E+A ++ +L + V D + Sbjct: 208 EVLDDSINMKHFESFKRADIYAMGLVFWEIARRCS--IGGIHEDYQLPYYDLVPSDPSVE 265 Query: 287 PPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPP 322 R + L + ++ I+ E Sbjct: 266 EMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECW 301 >4M66-A nrPDB Length = 325 Score = 163 bits (412), Expect = 1e-40, Method: Composition-based stats. Identities = 60/276 (21%), Positives = 108/276 (39%), Gaps = 28/276 (10%) Query: 63 LKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECN 122 + ++ +K+ +G G GVVF+ H+ +A K+++ + E++ + Sbjct: 17 VSREELKKLEFVGKGGFGVVFRAHHRTWNHDVAVKIVNSKKISW-------EVKAMVNLR 69 Query: 123 SPYIVGFYGAFYSDGEIS-----ICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGL 177 + ++ G + M+ GSL +L+ P +L ++ V+ G+ Sbjct: 70 NENVLLLLGVTEDLQWDFVSGQALVTRFMENGSLAGLLQPEAPRPWPLLCRLLQEVVLGM 129 Query: 178 TYLRE-KHKIMHRDVKPSNILVNSRGEIKLCDFGVSG--------QLIDSMANSFVGTRS 228 YL ++HRD+KPSNIL++ KL DFG+S S + GT + Sbjct: 130 CYLHSLDPPLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQSGSGSGSGSRDSGGTLA 189 Query: 229 YMSPERLQ--GTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAET 286 Y+ PE L S SD++S G+ + + GR + + D Sbjct: 190 YLDPELLFKVNLKASKASDVYSFGILVWAVLAGREA-----ELVDKTSLIRETVCDRQSR 244 Query: 287 PPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPP 322 PP P + G++ + I N P Sbjct: 245 PPLTELPPGSPETPGLEKLKELMIHCWGSQSENRPS 280 >4LQP-A nrPDB Length = 508 Score = 163 bits (412), Expect = 2e-40, Method: Composition-based stats. Identities = 67/333 (20%), Positives = 114/333 (34%), Gaps = 39/333 (11%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE--IKPAIRNQIIRELQVLHECNS 123 +DF + +G G G V V K +G + A K + K + E VL +S Sbjct: 102 EDFHTVKVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKDQLAHVKAERDVLAGSDS 161 Query: 124 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREK 183 P++V Y +F + + ME + GG L +L + E + I + + K Sbjct: 162 PWVVSLYYSFQDAQYLYLIMEFLPGGDLMTMLIRWQLFTEDVTRFYMAECILAIETIH-K 220 Query: 184 HKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFV----------------GTR 227 +HR +KP NIL++ RG IKL DFG+S + +++ GT Sbjct: 221 LGFIHRAIKPDNILIDIRGHIKLSDFGLSTGFHKTHDSNYYKKLLQQDEATNGISKPGT- 279 Query: 228 SYMSPER-LQGTHYSVQSDIWSMGLSL--------VEMAVGRYPIPPPDAKELELMFGCQ 278 Y + ++ D S+ L++ + + Sbjct: 280 -YNANTTDTANKRQTMVVD--SISLTMSNRQQIQTWRKSRRLMAYSTVGTPDYIAPEIFL 336 Query: 279 VEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVN-EPPPKLPSGV-FSLEFQD 336 +G E G E I+N E + P + S E +D Sbjct: 337 YQGYGQECDWWSLGAIMYECLIGWPPFCSETPQETYRKIMNFEQTLQFPDDIHISYEAED 396 Query: 337 FVNKCLIKNPAERA----DLKQLMVHAFIKRSD 365 + + L +R ++ H F + D Sbjct: 397 LIRRLLTH-ADQRLGRHGGADEIKSHPFFRGVD 428 >2RIO-A nrPDB Length = 434 Score = 162 bits (409), Expect = 3e-40, Method: Composition-based stats. Identities = 65/353 (18%), Positives = 133/353 (37%), Gaps = 84/353 (23%) Query: 72 SELGAGNGG-VVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECN-SPYIVGF 129 LG G+ G VVF+ S + G +A K + ++ + E+++L E + P ++ + Sbjct: 21 KILGYGSSGTVVFQGSFQ--GRPVAVKRMLIDFCDIA----LMEIKLLTESDDHPNVIRY 74 Query: 130 YGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILG-------KVSIAVIKGLTYLRE 182 Y + +D + I +E + +L +++ E + + + G+ +L Sbjct: 75 YCSETTDRFLYIALELCNL-NLQDLVESKNVSDENLKLQKEYNPISLLRQIASGVAHLHS 133 Query: 183 KHKIMHRDVKPSNILVN-------------SRGEIKLCDFGVSGQLIDSMA------NSF 223 KI+HRD+KP NILV+ I + DFG+ +L + N+ Sbjct: 134 L-KIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFRTNLNNP 192 Query: 224 VGTRSYMSPERLQG-------THYSVQSDIWSMGLSLVEMAV-GRYPIPPPDAKELELMF 275 GT + +PE L+ + DI+SMG + G++P ++E ++ Sbjct: 193 SGTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPFGDKYSRESNIIR 252 Query: 276 GCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQ 335 G IF L + L E Sbjct: 253 G---------------------------------IFSLDEM------KCLHDRSLIAEAT 273 Query: 336 DFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQPSTPT 388 D +++ + +P +R +++ H +++++F + + + P+ Sbjct: 274 DLISQMIDHDPLKRPTAMKVLRHPLF-WPKSKKLEFLLKVSDRLEIENRDPPS 325 >3SOC-A nrPDB Length = 322 Score = 159 bits (403), Expect = 1e-39, Method: Composition-based stats. Identities = 62/307 (20%), Positives = 108/307 (35%), Gaps = 48/307 (15%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIV 127 + + G G V+K +A K+ ++ K + +N+ E+ L I+ Sbjct: 26 LQLLEVKARGRFGCVWKAQLL--NEYVAVKIFPIQDKQSWQNE--YEVYSLPGMKHENIL 81 Query: 128 GFYGAFYSDG----EISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLR-- 181 F GA ++ + + GSL LK A + L ++ + +GL YL Sbjct: 82 QFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLK-ANVVSWNELCHIAETMARGLAYLHED 140 Query: 182 -------EKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSM----ANSFVGTRSYM 230 K I HRD+K N+L+ + + DFG++ + + VGTR YM Sbjct: 141 IPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYM 200 Query: 231 SPERLQG-----THYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAE 285 +PE L+G ++ D+++MGL L E+A P E L F ++ Sbjct: 201 APEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGP-VDEYMLPFEEEIGQH--- 256 Query: 286 TPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKN 345 P RP + + + + +C + Sbjct: 257 ----PSLEDMQEVVVHKKKRPVLRDY-------------WQKHAGMAMLCETIEECWDHD 299 Query: 346 PAERADL 352 R Sbjct: 300 AEARLSA 306 >4F9B-A nrPDB Length = 361 Score = 159 bits (401), Expect = 2e-39, Method: Composition-based stats. Identities = 73/350 (20%), Positives = 124/350 (35%), Gaps = 66/350 (18%) Query: 68 FEKISELGAGNGGVVFKVSHK---PSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNS- 123 F+ ++G G V+ + + +A K + P +I ELQ L Sbjct: 23 FKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPI---RIAAELQCLTVAGGQ 79 Query: 124 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREK 183 ++G F + + I M +++ S +L + Q + + + + K L + + Sbjct: 80 DNVMGVKYCFRKNDHVVIAMPYLEHESFLDILNS---LSFQEVREYMLNLFKALKRIH-Q 135 Query: 184 HKIMHRDVKPSNILVNSRGEIK-LCDFGVSGQLIDS------------------------ 218 I+HRDVKPSN L N R + L DFG++ D+ Sbjct: 136 FGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNKCSI 195 Query: 219 ------MANSFVGTRSYMSPERLQGTH-YSVQSDIWSMGLSLVEMAVGRYPIPPPDAKEL 271 GT + +PE L + D+WS G+ + + GRYP Sbjct: 196 CLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDDLT 255 Query: 272 ELMFGCQVEGDAAETPPRPRTPGRPL----------------SSYGMDSRPPMAIFELLD 315 L + G ET +T G+ + GMDS P ++ Sbjct: 256 ALAQIMTIRGSR-ETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSSTPKLTSDIQG 314 Query: 316 YIVN-EPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRS 364 + N E ++P + L + NPA R ++ ++H F K Sbjct: 315 HATNLEGWNEVPDEAYDLLDKLL-----DLNPASRITAEEALLHPFFKDM 359 >2BUJ-A nrPDB Length = 317 Score = 157 bits (397), Expect = 7e-39, Method: Composition-based stats. Identities = 61/286 (21%), Positives = 103/286 (36%), Gaps = 27/286 (9%) Query: 63 LKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECN 122 + + + I +LG G V V G A K I L + R + RE + N Sbjct: 26 IDNKHYLFIQKLGEGGFSYVDLVEGLHDGHFYALKRI-LCHEQQDREEAQREADMHRLFN 84 Query: 123 SPYIVGFYGAFYSDG----EISICMEHMDGGSL----DQVLKKAGRIPEQILGKVSIAVI 174 P I+ + E + + G+L +++ K + E + + + + Sbjct: 85 HPNILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFLTEDQILWLLLGIC 144 Query: 175 KGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVG--------- 225 +GL + K HRD+KP+NIL+ G+ L D G Q + S Sbjct: 145 RGLEAIHAK-GYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSRQALTLQDWAAQ 203 Query: 226 --TRSYMSPERLQGTHY---SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVE 280 T SY +PE + ++D+WS+G L M G P K + Q + Sbjct: 204 RCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPYDMVFQKGDSVALAVQNQ 263 Query: 281 GDAAETPPRPRTPGRPLSS---YGMDSRPPMAIFELLDYIVNEPPP 323 ++P + L+S RP + + + P P Sbjct: 264 LSIPQSPRHSSALWQLLNSMMTVDPHQRPHIPLLLSQLEALQPPAP 309 >5J0A-A nrPDB Length = 300 Score = 152 bits (385), Expect = 2e-37, Method: Composition-based stats. Identities = 68/311 (21%), Positives = 131/311 (42%), Gaps = 48/311 (15%) Query: 70 KISELGAGNGGVVFKVSHKPSGL---VMARKLIHLEIKPAIR----NQIIRELQVLHECN 122 + +LG G G V+ + P GL A K I+ R +++ E ++L + Sbjct: 13 FMQKLGFGTGVNVYLMKRSPRGLSHSPWAVKKINPICNDHYRSVYQKRLMDEAKILKSLH 72 Query: 123 SPYIVGFYGAFY-SDGEISICMEHMDGGSLDQVLKKA-----GRIPEQILGKVSIAVIKG 176 P IVG+ +DG + + ME+ SL+ ++++ P I+ KV++ + +G Sbjct: 73 HPNIVGYRAFTEANDGSLCLAMEYGGEKSLNDLIEERYKASQDPFPAAIILKVALNMARG 132 Query: 177 LTYLREKHKIMHRDVKPSNILVNSRGE-IKLCDFGVSGQLIDSMANS-----FVGTRSYM 230 L YL ++ K++H D+K SN+++ E IK+CD GVS L ++M + ++GT + Sbjct: 133 LKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMEVTDPEACYIGTEPWK 192 Query: 231 SPERLQGTHY-SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPR 289 E ++ + ++DI++ GL+L EM P + D + Sbjct: 193 PKEAVEENGVITDKADIFAFGLTLWEMMTLSIP-----------HINLSNDDDDEDKTFD 241 Query: 290 PRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAER 349 + +RPP+ + EL + + + C ++P +R Sbjct: 242 ESDFDDEAYYAALGTRPPINMEELDESYQK--------------VIELFSVCTNEDPKDR 287 Query: 350 ADLK---QLMV 357 + + Sbjct: 288 PSAAHIVEALE 298 >5VC6-A nrPDB Length = 289 Score = 152 bits (383), Expect = 4e-37, Method: Composition-based stats. Identities = 64/320 (20%), Positives = 121/320 (37%), Gaps = 77/320 (24%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQ-IIRELQVLHEC-NS 123 +F ++ ++G+G G VFK + G + A K + ++ Q +RE+ Sbjct: 11 TEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQH 70 Query: 124 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR----IPEQILGKVSIAVIKGLTY 179 ++V ++ A+ D + I E+ +GGSL + + R E L + + V +GL Y Sbjct: 71 SHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRY 130 Query: 180 LREKHKIMHRDVKPSNILVNSRG-------------------EIKLCDFGVSGQLIDSMA 220 + ++H D+KPSNI ++ K+ D G ++ Sbjct: 131 IHSM-SLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQV 189 Query: 221 NSFVGTRSYMSPERLQGTHYSV--QSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQ 278 G +++ E LQ +Y+ ++DI+++ L++V A G P+P + E+ G Sbjct: 190 EE--GDSRFLANEVLQ-ENYTHLPKADIFALALTVV-CAAGAEPLPRNGDQWHEIRQGRL 245 Query: 279 VEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFV 338 P++P V S EF + + Sbjct: 246 --------------------------------------------PRIP-QVLSQEFTELL 260 Query: 339 NKCLIKNPAERADLKQLMVH 358 + +P R L+ H Sbjct: 261 KVMIHPDPERRPSAMALVKH 280 >5TE0-A nrPDB Length = 347 Score = 151 bits (382), Expect = 4e-37, Method: Composition-based stats. Identities = 58/287 (20%), Positives = 112/287 (39%), Gaps = 28/287 (9%) Query: 69 EKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECN-SPYIV 127 L G +VF V +G+ A K + + + + RE+Q++ + + IV Sbjct: 22 TVDEVLAEGGFAIVFLVR-TSNGMKCALKRMFVNNEHDL-QVCKREIQIMRDLSGHKNIV 79 Query: 128 GFYGAFYSD------GEISICMEHMDGGSLDQVLKKA--GRIPEQILGKVSIAVIKGLTY 179 G+ + ++ E+ I M+ GG + ++ + E + ++ + + Sbjct: 80 GYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVAR 139 Query: 180 LRE-KHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFV----------GTRS 228 L + K I+HRD+K NIL++ RG LCDFG + + V T S Sbjct: 140 LHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLS 199 Query: 229 YMSPERLQ---GTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAE 285 Y +PE + G + ++DIW++G L ++ P ++ + G D + Sbjct: 200 YRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPF---GESQVAICDGNFTIPDNSR 256 Query: 286 TPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSL 332 R + D RP + + + + +P+ S Sbjct: 257 YSQDMHCLIRYMLEPDPDKRPDIYQVSYFSFKLLKKECPIPNVQNSP 303 >2QLU-A nrPDB Length = 314 Score = 150 bits (379), Expect = 9e-37, Method: Composition-based stats. Identities = 66/308 (21%), Positives = 113/308 (36%), Gaps = 35/308 (11%) Query: 61 GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE 120 G + + + G G V+K +A K+ L+ K + +++ RE+ Sbjct: 10 GLVPRGSLQLLEIKARGRFGCVWKAQLMND--FVAVKIFPLQDKQSWQSE--REIFSTPG 65 Query: 121 CNSPYIVGFYGAFYSDG----EISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKG 176 ++ F A E+ + D GSL LK I L V+ + +G Sbjct: 66 MKHENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLK-GNIITWNELCHVAETMSRG 124 Query: 177 LTYLR----------EKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSM----ANS 222 L+YL K I HRD K N+L+ S L DFG++ + + Sbjct: 125 LSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHG 184 Query: 223 FVGTRSYMSPERLQG-----THYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGC 277 VGTR YM+PE L+G ++ D+++MGL L E+ P E L F Sbjct: 185 QVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGP-VDEYMLPFEE 243 Query: 278 QVEGDAAETPPRPRT---PGRPLSSYGMDSRPPMA--IFELLDYIVNEPPPKLPSGVFSL 332 ++ + + RP P +A + + ++ +L +G Sbjct: 244 EIGQHPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEE 303 Query: 333 EFQDFVNK 340 + + Sbjct: 304 RV-SLIRR 310 >5IKW-A nrPDB Length = 310 Score = 150 bits (379), Expect = 1e-36, Method: Composition-based stats. Identities = 53/233 (22%), Positives = 95/233 (40%), Gaps = 26/233 (11%) Query: 54 LTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIR 113 ++ +V + L G VF V G+ A K +++ P + N R Sbjct: 2 MSVGVRVFAVGRHQVTLEESLAEGGFSTVFLVR-THGGIRCALKRMYVNNMPDL-NVCKR 59 Query: 114 ELQVLHECN-SPYIVGFYGAFYSD-----GEISICMEHMDGGSLDQVLKKA--GRIPEQI 165 E+ ++ E + IVG+ + E+ I ME+ G + + K E Sbjct: 60 EITIMKELSGHKNIVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPE 119 Query: 166 LGKVSIAVIKGLTYLRE-KHKIMHRDVKPSNILVNSRGEIKLCDFGVSG----------- 213 + ++ + + L + K I+HRD+K NIL+N G LCDFG + Sbjct: 120 VLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGV 179 Query: 214 QLIDSMANSFVGTRSYMSPERLQ---GTHYSVQSDIWSMGLSLVEMAVGRYPI 263 +++ + T SY +PE + G + ++DIW++G L ++ P Sbjct: 180 NVVEEEIKKYT-TLSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPF 231 >2Y4I-B nrPDB Length = 319 Score = 148 bits (374), Expect = 4e-36, Method: Composition-based stats. Identities = 59/314 (18%), Positives = 121/314 (38%), Gaps = 32/314 (10%) Query: 27 ETNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVS 86 E NL L + ++ + FL + ++ + E +G G G V+ Sbjct: 3 EMNLSLLSARSFP-----RKASQTSIFLQE----WDIPFEQLEIGELIGKGRFGQVYHGR 53 Query: 87 HKPSGLVMARKLIHLEIK-PAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEH 145 +A +LI +E RE+ + +V F GA S ++I Sbjct: 54 WHG---EVAIRLIDIERDNEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSL 110 Query: 146 MDGGSLDQVLKKAG-RIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEI 204 G +L V++ A + +++ ++KG+ YL K I+H+D+K N+ + G++ Sbjct: 111 CKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAK-GILHKDLKSKNVFYD-NGKV 168 Query: 205 KLCDFGV---SGQLIDSMANSFV----GTRSYMSPERLQG---------THYSVQSDIWS 248 + DFG+ SG L + G +++PE ++ +S SD+++ Sbjct: 169 VITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFA 228 Query: 249 MGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPM 308 +G E+ +P A+ + G ++ + ++ L + + Sbjct: 229 LGTIWYELHAREWPFKTQPAEAIIWQMGTGMKPNLSQIGMGKEISDILLFCWAFEQEERP 288 Query: 309 AIFELLDYIVNEPP 322 +L+D + P Sbjct: 289 TFTKLMDMLEKLPK 302 >4BTK-A nrPDB Length = 337 Score = 148 bits (374), Expect = 4e-36, Method: Composition-based stats. Identities = 47/230 (20%), Positives = 94/230 (40%), Gaps = 20/230 (8%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNS-P 124 D ++ + ++G G G +++ + +A K+ E + + E+ VL + Sbjct: 56 DRWKVLKKIGGGGFGEIYEAMDLLTRENVALKV---ESAQQPKQVLKMEVAVLKKLQGKD 112 Query: 125 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKK--AGRIPEQILGKVSIAVIKGLTYLRE 182 ++ F G ++ + M+ G +L + + G ++ +++ + + Sbjct: 113 HVCRFIGCGRNEKFNYVVMQL-QGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHS 171 Query: 183 KHKIMHRDVKPSNI----LVNSRGEIKLCDFGVSGQLIDSMAN--------SFVGTRSYM 230 +HRD+KPSN L ++ + + DFG++ Q ++ + F GT Y Sbjct: 172 -VGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRYA 230 Query: 231 SPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVE 280 S + D+WS+ LVE AVG+ P KE M + E Sbjct: 231 SVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKEKYE 280 >4NFN-A nrPDB Length = 309 Score = 147 bits (371), Expect = 7e-36, Method: Composition-based stats. Identities = 47/230 (20%), Positives = 94/230 (40%), Gaps = 20/230 (8%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNS-P 124 D ++ + ++G G G +++ + +A K+ E + + E+ VL + Sbjct: 21 DRWKVLKKIGGGGFGEIYEAMDLLTRENVALKV---ESAQQPKQVLKMEVAVLKKLQGKD 77 Query: 125 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKK--AGRIPEQILGKVSIAVIKGLTYLRE 182 ++ F G ++ + M+ G +L + + G ++ +++ + + Sbjct: 78 HVCRFIGCGRNEKFNYVVMQL-QGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHS 136 Query: 183 KHKIMHRDVKPSNI----LVNSRGEIKLCDFGVSGQLIDSMAN--------SFVGTRSYM 230 +HRD+KPSN L ++ + + DFG++ Q ++ + F GT Y Sbjct: 137 -VGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRYA 195 Query: 231 SPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVE 280 S + D+WS+ LVE AVG+ P KE M + E Sbjct: 196 SVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKEKYE 245 >6HV0-A nrPDB Length = 416 Score = 145 bits (366), Expect = 3e-35, Method: Composition-based stats. Identities = 59/312 (18%), Positives = 112/312 (35%), Gaps = 68/312 (21%) Query: 68 FEKISELGAGNGGV-VFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECN-SPY 125 F LG G G V++ +A K I P + RE+Q+L E + P Sbjct: 10 FCPKDVLGHGAEGTIVYRGMF--DNRDVAVKRI----LPECFSFADREVQLLRESDEHPN 63 Query: 126 IVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAG--RIPEQILGKVSIAVIKGLTYLREK 183 ++ ++ I +E +L + +++ + + + + GL +L Sbjct: 64 VIRYFCTEKDRQFQYIAIELCAA-TLQEYVEQKDFAHLGLEPI-TLLQQTTSGLAHLHSL 121 Query: 184 HKIMHRDVKPSNILV---NSRGEIK--LCDFGVSGQL-----IDSMANSFVGTRSYMSPE 233 + I+HRD+KP NIL+ N+ G+IK + DFG+ +L S + GT +++PE Sbjct: 122 N-IVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPE 180 Query: 234 RLQG---THYSVQSDIWSMGLSLVEMAV-GRYPIPPPDAKELELMFGCQVEGDAAETPPR 289 L + + DI+S G + G +P ++ ++ G Sbjct: 181 MLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANILLGACSLDCL------ 234 Query: 290 PRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAER 349 P + ++ + K + +P +R Sbjct: 235 -----------------------------------HPEKHEDVIARELIEKMIAMDPQKR 259 Query: 350 ADLKQLMVHAFI 361 K ++ H F Sbjct: 260 PSAKHVLKHPFF 271 >4L68-A nrPDB Length = 340 Score = 145 bits (365), Expect = 4e-35, Method: Composition-based stats. Identities = 53/281 (18%), Positives = 112/281 (39%), Gaps = 18/281 (6%) Query: 57 KQKVGEL--KDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRE 114 K K+G+L ++F + + + G +K P G +A K HL + E Sbjct: 29 KVKLGDLMAATNNFNSENIIVSTRTGTTYKA-LLPDGSALAVK--HLSTCKLGEREFRYE 85 Query: 115 LQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLK-KAGRIPEQILGKVSIAV 173 + L E + G + E + ++M G+L +L G + ++ + Sbjct: 86 MNQLWELRHSNLAPLLGFCVVEEEKFLVYKYMSNGTLHSLLDSNRGELDWSTRFRIGLGA 145 Query: 174 IKGLTYLRE--KHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLI------DSMANSFVG 225 +GL +L + I+H+++ S IL++ + ++ D G++ ++ S +G Sbjct: 146 ARGLAWLHHGCRPPILHQNICSSVILIDEDFDARIIDSGLARLMVPSDNNESSFMTGDLG 205 Query: 226 TRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAE 285 Y++PE S++ D++ +G+ L+E+A G + K + + Q+E Sbjct: 206 EFGYVAPEYSTTMLASLKGDVYGLGVVLLELATGLKAVGGEGFKGSLVDWVKQLESSG-- 263 Query: 286 TPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLP 326 T + G D + L+ + + P + Sbjct: 264 --RIAETFDENIRGKGHDEEISKFVEIALNCVSSRPKERWS 302 >4PL5-B nrPDB Length = 435 Score = 144 bits (363), Expect = 6e-35, Method: Composition-based stats. Identities = 66/348 (18%), Positives = 125/348 (35%), Gaps = 77/348 (22%) Query: 32 ALQKKLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGV-VFKVSHKPS 90 A+ + LE D++ + T+ VG++ F LG G G V+K Sbjct: 2 AMDPEFPSLEQDDEDEE------TRMVIVGKIS---FCPKDVLGHGAEGTIVYKGMF--D 50 Query: 91 GLVMARKLIHLEIKPAIRNQIIRELQVLHECN-SPYIVGFYGAFYSDGEISICMEHMDGG 149 +A K I P + RE+Q+L E + P ++ ++ I +E Sbjct: 51 NRDVAVKRI----LPECFSFADREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAA- 105 Query: 150 SLDQVLKKAG--RIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILV---NSRGEI 204 +L + +++ + + + + GL +L + I+HRD+KP NIL+ N+ G I Sbjct: 106 TLQEYVEQKDFAHLGLEPI-TLLHQTTSGLAHLHSLN-IVHRDLKPHNILLSMPNAHGRI 163 Query: 205 K--LCDFGVSGQL-----IDSMANSFVGTRSYMSPERLQG---THYSVQSDIWSMGLSLV 254 K + DFG+ +L S + GT +++PE L + + DI+S G Sbjct: 164 KAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKDNPTYTVDIFSAGCVFY 223 Query: 255 EMAV-GRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFEL 313 + G +P ++ ++ G Sbjct: 224 YVISEGYHPFGKSLQRQANILLGACNLDCF------------------------------ 253 Query: 314 LDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFI 361 + ++ + K + +P +R K ++ H F Sbjct: 254 -----------HSDKHEDVIARELIEKMIAMDPQQRPSAKHVLKHPFF 290 >4M69-B nrPDB Length = 283 Score = 144 bits (362), Expect = 8e-35, Method: Composition-based stats. Identities = 54/245 (22%), Positives = 108/245 (44%), Gaps = 20/245 (8%) Query: 79 GGVVFKVSHKPSGLVMARKLIHLEIKPAI---RNQIIRELQVLHECNSPYIVGFYGAFYS 135 +++ + S + K+ + ++ R E++ + + +SP I+ +G Sbjct: 22 MSTIYRGEYHRS--PVTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICID 79 Query: 136 DG----EISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDV 191 E SI ME+ + G+L ++L + + + + + +GL L + +HR++ Sbjct: 80 QTVKPPEFSIVMEYCELGTLRELLDREKDLTMSVRSLLVLRAARGLYRLHHS-ETLHRNI 138 Query: 192 KPSNILVNSRGEIKLCDFGVSG--QLIDSMANSFVGTRS----YMSPERLQG--THYSVQ 243 S+ LV ++KL F +S I A S RS Y+SPERL+ Y ++ Sbjct: 139 SSSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDIK 198 Query: 244 SDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAA--ETPPRPRTPGRPLSSYG 301 ++I+S G+ L E+A G+ P D+K++ + + + + P R ++ Sbjct: 199 AEIYSFGIVLWEIATGKIPFEGCDSKKIRELVAEDKKQEPVGQDCPELLREIINECRAHE 258 Query: 302 MDSRP 306 RP Sbjct: 259 PSQRP 263 >3SV0-A nrPDB Length = 483 Score = 143 bits (361), Expect = 1e-34, Method: Composition-based stats. Identities = 49/269 (18%), Positives = 104/269 (38%), Gaps = 33/269 (12%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNS-- 123 + F ++G+G+ G ++ ++ + +A KL +++ K Q++ E ++ Sbjct: 7 NKFRLGRKIGSGSFGEIYLGTNIQTNEEVAIKLENVKTK---HPQLLYESKIYRILQGGT 63 Query: 124 --PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR-IPEQILGKVSIAVIKGLTYL 180 P V ++G + M+ + G SL+ + R + + + ++ +I + ++ Sbjct: 64 GIPN-VRWFGV--EGDYNVLVMDLL-GPSLEDLFNFCSRKLSLKTVLMLADQMINRVEFV 119 Query: 181 REKHKIMHRDVKPSNILVN---SRGEIKLCDFGVSGQLIDSMA---------NSFVGTRS 228 K +HRD+KP N L+ ++ + DFG++ + D+ + GT Sbjct: 120 HSK-SFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDTSTHQHIPYRENKNLTGTAR 178 Query: 229 YMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQ--------VE 280 Y S G S + D+ S+G L+ G P A + + +E Sbjct: 179 YASVNTHLGIEQSRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKYEKISEKKVATSIE 238 Query: 281 GDAAETPPRPRTPGRPLSSYGMDSRPPMA 309 P + S D +P + Sbjct: 239 ALCRGYPTEFASYFHYCRSLRFDDKPDYS 267 >5X18-A nrPDB Length = 295 Score = 143 bits (361), Expect = 1e-34, Method: Composition-based stats. Identities = 52/234 (22%), Positives = 95/234 (40%), Gaps = 21/234 (8%) Query: 67 DFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNS-PY 125 ++ ++G G+ GV+F+ ++ +G+ +A K E + Q+ E + N P Sbjct: 8 HYKIGKKIGEGSFGVLFEGTNMINGVPVAIKF---EPRKTEAPQLRDEYKTYKILNGTPN 64 Query: 126 IVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR-IPEQILGKVSIAVIKGLTYLREKH 184 I Y + ++ + G SL+ + GR + + +V++ +I + L H Sbjct: 65 IPYAYYFGQEGLHNILVIDLL-GPSLEDLFDWCGRKFSVKTVVQVAVQMITLIEDLH-AH 122 Query: 185 KIMHRDVKPSNILVNSRGE-----IKLCDFGVSGQLIDSMAN---------SFVGTRSYM 230 +++RD+KP N L+ G+ I L DFG++ Q D S GT YM Sbjct: 123 DLIYRDIKPDNFLIGRPGQPDANNIHLIDFGMAKQYRDPKTKQHIPYREKKSLSGTARYM 182 Query: 231 SPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAA 284 S G S + D+ ++G G P A + + E + Sbjct: 183 SINTHLGREQSRRDDMEALGHVFFYFLRGHLPWQGLKAPNNKQKYEKIGEKKRS 236 >4BTF-A nrPDB Length = 469 Score = 143 bits (361), Expect = 1e-34, Method: Composition-based stats. Identities = 54/245 (22%), Positives = 108/245 (44%), Gaps = 20/245 (8%) Query: 79 GGVVFKVSHKPSGLVMARKLIHLEIKPAI---RNQIIRELQVLHECNSPYIVGFYGAFYS 135 +++ + S + K+ + ++ R E++ + + +SP I+ +G Sbjct: 208 MSTIYRGEYHRS--PVTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICID 265 Query: 136 DG----EISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDV 191 E SI ME+ + G+L ++L + + + + + +GL L + +HR++ Sbjct: 266 QTVKPPEFSIVMEYCELGTLRELLDREKDLTMSVRSLLVLRAARGLYRLHHS-ETLHRNI 324 Query: 192 KPSNILVNSRGEIKLCDFGVSG--QLIDSMANSFVGTRS----YMSPERLQG--THYSVQ 243 S+ LV ++KL F +S I A S RS Y+SPERL+ Y ++ Sbjct: 325 SSSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDIK 384 Query: 244 SDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAA--ETPPRPRTPGRPLSSYG 301 ++I+S G+ L E+A G+ P D+K++ + + + + P R ++ Sbjct: 385 AEIYSFGIVLWEIATGKIPFEGCDSKKIRELVAEDKKQEPVGQDCPELLREIINECRAHE 444 Query: 302 MDSRP 306 RP Sbjct: 445 PSQRP 449 >5FQD-C nrPDB Length = 341 Score = 143 bits (360), Expect = 1e-34, Method: Composition-based stats. Identities = 53/262 (20%), Positives = 102/262 (38%), Gaps = 26/262 (9%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNS---- 123 ++ + ++G+G+ G ++ + +G +A K LE + A Q++ E ++ Sbjct: 21 YKLVRKIGSGSFGDIYLAINITNGEEVAVK---LESQKARHPQLLYESKLYKILQGGVGI 77 Query: 124 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKA-GRIPEQILGKVSIAVIKGLTYLRE 182 P+I +YG + M+ + G SL+ + R + + ++ +I + Y+ Sbjct: 78 PHI-RWYG--QEKDYNVLVMDLL-GPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHT 133 Query: 183 KHKIMHRDVKPSNILVNSRGEIK---LCDFGVSGQLIDSMA---------NSFVGTRSYM 230 K+ +HRD+KP N L+ L DFG++ + D+ + GT Y Sbjct: 134 KN-FIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYA 192 Query: 231 SPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRP 290 S G S + D+ S+G L+ P A + + ++ TP Sbjct: 193 SINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYE-KISEKKMSTPVEV 251 Query: 291 RTPGRPLSSYGMDSRPPMAIFE 312 G P + FE Sbjct: 252 LCKGFPAEFAMYLNYCRGLRFE 273 >4TN6-A nrPDB Length = 318 Score = 141 bits (356), Expect = 4e-34, Method: Composition-based stats. Identities = 50/261 (19%), Positives = 100/261 (38%), Gaps = 20/261 (7%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPY 125 + + ++G+G+ G ++ + +G +A K LE Q+ E ++ Sbjct: 7 NRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIK---LECVKTKHPQLHIESKIYKMMQGGV 63 Query: 126 IVGFYGAFYSDGEIS-ICMEHMDGGSLDQVLKKAGR-IPEQILGKVSIAVIKGLTYLREK 183 + ++G+ + + ME + G SL+ + R + + ++ +I + Y+ K Sbjct: 64 GIPTIRWCGAEGDYNVMVMELL-GPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSK 122 Query: 184 HKIMHRDVKPSNILV---NSRGEIKLCDFGVSGQLIDSMA---------NSFVGTRSYMS 231 + +HRDVKP N L+ + + DFG++ + D+ + GT Y S Sbjct: 123 N-FIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYAS 181 Query: 232 PERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPR 291 G S + D+ S+G L+ +G P A + ++ TP Sbjct: 182 INTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYE-RISEKKMSTPIEVL 240 Query: 292 TPGRPLSSYGMDSRPPMAIFE 312 G P + F+ Sbjct: 241 CKGYPSEFATYLNFCRSLRFD 261 >3QD2-B nrPDB Length = 332 Score = 140 bits (353), Expect = 8e-34, Method: Composition-based stats. Identities = 61/328 (18%), Positives = 108/328 (32%), Gaps = 81/328 (24%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMAR-------------KLIHL----------- 101 DFE I +G G GVVF+ +K A K++ Sbjct: 6 TDFEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPG 65 Query: 102 --------------EIKPAIRNQIIR-------------------ELQVLHECNSPYIVG 128 + + + ++ +++ + ++ VG Sbjct: 66 IVRYFNAWLETPPEKWQEEMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFSTKNTVG 125 Query: 129 FYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQI---LGKVSIAVIKGLTYLREKHK 185 + I M+ +L + + + ++ + I + + + +L K Sbjct: 126 QLQPSSPKVYLYIQMQLCRKENLKDWMNRRCSLEDREHGVCLHIFIQIAEAVEFLHSK-G 184 Query: 186 IMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSM--------------ANSFVGTRSYMS 231 +MHRD+KPSNI +K+ DFG+ + VGT+ YMS Sbjct: 185 LMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQVGTKLYMS 244 Query: 232 PERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPR 291 PE++ G +YS + DI+S+GL L E+ + + V + Sbjct: 245 PEQIHGNNYSHKVDIFSLGLILFELLY------SFSTQMERVRIITDVRNLKFPLLFTQK 298 Query: 292 TPGRPLSSYGMDSRPPMAIFELLDYIVN 319 P + M S P E D I N Sbjct: 299 YPQEHMMVQDMLSPSPTERPEATDIIEN 326 >5VDK-A nrPDB Length = 297 Score = 140 bits (352), Expect = 1e-33, Method: Composition-based stats. Identities = 56/319 (17%), Positives = 112/319 (35%), Gaps = 79/319 (24%) Query: 65 DDDFEKISELGAGNGGVVFKVSHKPSGLVMARKL-IHLEIKPAIRNQIIRELQVLHEC-N 122 + +F ++ ++G G G V+K + G V A K + + + N + E+ + Sbjct: 14 EKEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSALHEVYAHAVLGH 73 Query: 123 SPYIVGFYGAFYSDGEISICMEHMDGGSLDQVL----KKAGRIPEQILGKVSIAVIKGLT 178 P++V +Y ++ D + I E+ +GGSL + K E L + + + GL Sbjct: 74 HPHVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQISLGLN 133 Query: 179 YLREKHKIMHRDVKPSNILVNSRGE-----------------------IKLCDFGVSGQL 215 Y+ ++H D+KPSNI + + + K+ D G + + Sbjct: 134 YIHNS-SMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIGDLGHATSI 192 Query: 216 IDSMANSFVGTRSYMSPERLQ-GTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELM 274 G +++ E LQ + ++DI+++GL++ +A G +P A Sbjct: 193 NKPKVEE--GDSRFLANEILQEDYRHLPKADIFALGLTIA-VAAGAESLPTNGA------ 243 Query: 275 FGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEF 334 +I P +P + S F Sbjct: 244 --------------------------------------AWHHIRKGNFPDVPQEL-SESF 264 Query: 335 QDFVNKCLIKNPAERADLK 353 + + + +R Sbjct: 265 SSLLKNMIQPDAEQRPSAA 283 >2CHL-A nrPDB Length = 351 Score = 137 bits (346), Expect = 6e-33, Method: Composition-based stats. Identities = 57/267 (21%), Positives = 103/267 (38%), Gaps = 24/267 (8%) Query: 67 DFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHEC-NSPY 125 +F ++G GN G + + + +A KL ++ + Q+ E + + + Sbjct: 31 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRA---PQLHLEYRFYKQLGSGDG 87 Query: 126 IVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR-IPEQILGKVSIAVIKGLTYLREKH 184 I Y ++ +E + G SL+ + R + + ++I +I + Y+ K+ Sbjct: 88 IPQVYYFGPCGKYNAMVLELL-GPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKN 146 Query: 185 KIMHRDVKPSNILVNSRGE-----IKLCDFGVSGQLIDSMAN---------SFVGTRSYM 230 +++RDVKP N L+ G I + DF ++ + ID S GT YM Sbjct: 147 -LIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYM 205 Query: 231 SPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRP 290 S G S + D+ ++G + G P A L+ + Q GD P Sbjct: 206 SINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERY--QKIGDTKRATPIE 263 Query: 291 RTP-GRPLSSYGMDSRPPMAIFELLDY 316 P + + + FE DY Sbjct: 264 VLCENFPEMATYLRYVRRLDFFEKPDY 290 >5M07-A nrPDB Length = 276 Score = 137 bits (345), Expect = 7e-33, Method: Composition-based stats. Identities = 50/213 (23%), Positives = 92/213 (43%), Gaps = 21/213 (9%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIH--LEIKPAIRNQIIRELQVLHECNSPY 125 + + LGA G V+ V H A K++ + R + RE +V P+ Sbjct: 32 YTVVRMLGASAMGEVYLVQHPGFPGWQALKVLSPAMAADDEFRRRFQRETEVAARLFHPH 91 Query: 126 IVGFYGAFYSDGEISICMEHMDGGSLDQVL--KKAGRIPEQILGKVSIAVIKGLTYLREK 183 I+ + DG++ I M+++DG Q + + +P + + AV L Y ++ Sbjct: 92 ILEVHDRGEFDGQLWIAMDYVDGIDATQHMADRFPAVLPVGEVLAIVTAVAGALDYAHQR 151 Query: 184 HKIMHRDVKPSNILVNS----RGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTH 239 ++HRDV P+N+++ S I L DFG++ Q SY +PE G Sbjct: 152 -GLLHRDVNPANVVLTSQSAGDQRILLADFGIASQ------------PSYPAPELSAGAD 198 Query: 240 YSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELE 272 ++D +++ L+ + + G P+ L+ Sbjct: 199 VDGRADQYALALTAIHLFAGAPPVDRSHTGPLQ 231 >4MWI-A nrPDB Length = 294 Score = 137 bits (344), Expect = 1e-32, Method: Composition-based stats. Identities = 46/280 (16%), Positives = 104/280 (37%), Gaps = 58/280 (20%) Query: 94 MARKLIHL---EIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDG----EISICMEHM 146 +A K+ +R +E++ + + SP I+ +G + + SI ME+ Sbjct: 50 VAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYC 109 Query: 147 DGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREK-HKIMHRDVKPSNILVNSRGEIK 205 + G+L ++L + + + + +GL L +H ++ SN LV ++K Sbjct: 110 ELGTLRELLDREKDLTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQVK 169 Query: 206 LCDFGVSGQLID------SMANSFVGTRSYMSPERLQG--THYSVQSDIWSMGLSLVEMA 257 L F + V + +Y+SP+ L+ Y V+S+I+S G+ L E+A Sbjct: 170 LAGFELRKTQTSMSLGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWEIA 229 Query: 258 VGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYI 317 G P +++++ + + + + Sbjct: 230 TGDIPFQGCNSEKIRKLVAVKRQQEPLGEDC----------------------------- 260 Query: 318 VNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMV 357 E ++ +++C +P+ R + +++ Sbjct: 261 -------------PSELREIIDECRAHDPSVRPSVDEILK 287 >4XHH-A nrPDB Length = 403 Score = 136 bits (342), Expect = 2e-32, Method: Composition-based stats. Identities = 60/286 (20%), Positives = 106/286 (37%), Gaps = 27/286 (9%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIV 127 F ++G+G+ G ++ ++ SG +A I LE + Q+ E +V + + Sbjct: 9 FRIGRKIGSGSFGDIYHGTNLISGEEVA---IRLESIRSRHPQLDYESRVYKYLSGGVGI 65 Query: 128 GFYGAFYSDGEIS-ICMEHMDGGSLDQVLKKAGR-IPEQILGKVSIAVIKGLTYLREKHK 185 F F +GE + + ++ + G SL+ + R + + +++ +I + Y+ + Sbjct: 66 PFIRWFGREGEYNAMVIDLL-GPSLEDLFNYCHRKFSFKTVIMLALQMICRVQYIHGR-S 123 Query: 186 IMHRDVKPSNILVN---SRGEIKLCDFGVSGQLID---------SMANSFVGTRSYMSPE 233 +HRD+KP N L+ + + DFG+S + D S GT Y S Sbjct: 124 FIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTARYASVN 183 Query: 234 RLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKE--------LELMFGCQVEGDAAE 285 G S + D+ S+G L+ G P A LE VE A Sbjct: 184 THLGIEQSRRDDLESLGYMLIYFCKGSLPWQGLKATTKKQKYDRILEKKLCISVETLCAG 243 Query: 286 TPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFS 331 P + D RP L ++ +F Sbjct: 244 LPLEFSEYMNYCRNLKFDERPDYLYLARLFKDLSIKLEYHNDHLFD 289 >2C47-A nrPDB Length = 313 Score = 136 bits (342), Expect = 2e-32, Method: Composition-based stats. Identities = 54/243 (22%), Positives = 95/243 (39%), Gaps = 23/243 (9%) Query: 67 DFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECN-SPY 125 +F ++G GN G + + + +A K LE + Q+ E + + + + Sbjct: 5 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIK---LEPIKSRAPQLHLEYRFYKQLSATEG 61 Query: 126 IVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR-IPEQILGKVSIAVIKGLTYLREKH 184 + Y ++ +E + G SL+ + R + + ++I +I + Y+ K Sbjct: 62 VPQVYYFGPCGKYNAMVLELL-GPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYVHTK- 119 Query: 185 KIMHRDVKPSNILVNSRGE-----IKLCDFGVSGQLIDSMAN---------SFVGTRSYM 230 +++RDVKP N LV G I + DFG++ + ID S GT YM Sbjct: 120 SLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYM 179 Query: 231 SPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRP 290 S G S + D+ ++G + G P A L+ + Q GD P Sbjct: 180 SINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERY--QKIGDTKRATPIE 237 Query: 291 RTP 293 Sbjct: 238 VLC 240 >2CMW-A nrPDB Length = 310 Score = 134 bits (338), Expect = 5e-32, Method: Composition-based stats. Identities = 52/237 (21%), Positives = 94/237 (39%), Gaps = 24/237 (10%) Query: 69 EKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNS--PYI 126 ++G GN G + + + +A K LE + Q+ E + + S + Sbjct: 3 RVGKKIGCGNFGELRLGKNLYTNEYVAIK---LEPIKSRAPQLHLEYRFYKQLGSAGEGL 59 Query: 127 VGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR-IPEQILGKVSIAVIKGLTYLREKHK 185 Y ++ +E + G SL+ + R + + ++I ++ + Y+ K+ Sbjct: 60 PQVYYFGPCGKYNAMVLELL-GPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYVHSKN- 117 Query: 186 IMHRDVKPSNILVNSRGE-----IKLCDFGVSGQLIDSMAN---------SFVGTRSYMS 231 +++RDVKP N L+ +G I + DFG++ + ID S GT YMS Sbjct: 118 LIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMS 177 Query: 232 PERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPP 288 G S + D+ ++G + G P A L+ + Q GD P Sbjct: 178 INTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERY--QKIGDTKRNTP 232 >4XHL-A nrPDB Length = 394 Score = 134 bits (337), Expect = 7e-32, Method: Composition-based stats. Identities = 56/286 (19%), Positives = 106/286 (37%), Gaps = 27/286 (9%) Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIV 127 F ++G+G+ G ++ ++ SG +A I LE + Q+ E +V + + Sbjct: 9 FRIGRKIGSGSFGDIYHGTNLISGEEVA---IRLESIRSRHPQLDYESRVYRYLSGGVGI 65 Query: 128 GFYGAFYSDGEIS-ICMEHMDGGSLDQVLKK-AGRIPEQILGKVSIAVIKGLTYLREKHK 185 F F +GE + + ++ + G SL+ + R + + +++ + + Y+ + Sbjct: 66 PFIRWFGREGEYNAMVIDLL-GPSLEDLFNYCHRRFSFKTVIMLALQMFCRIQYIHGR-S 123 Query: 186 IMHRDVKPSNILVN---SRGEIKLCDFGVSGQLID---------SMANSFVGTRSYMSPE 233 +HRD+KP N L+ + + DFG+S + D S GT Y S Sbjct: 124 FIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTARYASVN 183 Query: 234 RLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKE--------LELMFGCQVEGDAAE 285 G S + D+ S+G L+ G P A +E VE + Sbjct: 184 THLGIEQSRRDDLESLGYVLIYFCKGSLPWQGLKATTKKQKYDRIMEKKLNVSVETLCSG 243 Query: 286 TPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFS 331 P + + D +P L ++ +F Sbjct: 244 LPLEFQEYMAYCKNLKFDEKPDYLFLARLFKDLSIKLEYHNDHLFD 289 >4NT4-A nrPDB Length = 312 Score = 134 bits (337), Expect = 7e-32, Method: Composition-based stats. Identities = 50/246 (20%), Positives = 94/246 (38%), Gaps = 23/246 (9%) Query: 67 DFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKP---AIRNQIIRELQVLHECNS 123 +F ++G GN G + + + +A K+ ++ K + + + L + Sbjct: 13 NFRVGKKIGCGNFGELRLGKNLYNNEHVAIKMEPMKSKAPQLHLEYRFYKLLGSHADNAP 72 Query: 124 PYIVGFYGAFYSDGEIS-ICMEHMDGGSLDQVLKKAGR-IPEQILGKVSIAVIKGLTYLR 181 I Y G + + +E + G SL+ + R + + ++ ++ + Y+ Sbjct: 73 DGIPRIYHLGTCGGRYNAMVLELL-GLSLEDLFNICARKFSLKTVLMIAKQLLHRIEYVH 131 Query: 182 EKHKIMHRDVKPSNILVNSRGE-----IKLCDFGVSGQLID---------SMANSFVGTR 227 +H +++RDVKP N L+ I + DFG++ + ID S GT Sbjct: 132 SRH-LIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRHIPYREHKSLTGTA 190 Query: 228 SYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETP 287 YMS G S + D+ ++G + G P A L+ + Q GD Sbjct: 191 RYMSINTHMGREQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERY--QKIGDTKRAT 248 Query: 288 PRPRTP 293 P Sbjct: 249 PIEVLC 254 >3VHK-A nrPDB Length = 368 Score = 132 bits (332), Expect = 2e-31, Method: Composition-based stats. Identities = 46/206 (22%), Positives = 74/206 (35%), Gaps = 48/206 (23%) Query: 158 AGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID 217 + + L S V KG+ +L + K +HRD+ NIL++ + +K+CDFG++ + Sbjct: 194 KDFLTLEHLICYSFQVAKGMEFLASR-KCIHRDLAARNILLSEKNVVKICDFGLARDIYK 252 Query: 218 SMANSFVGTRS----YMSPERLQGTHYSVQSDIWSMGLSLVEMAV-GRYPIPPPDAKELE 272 G +M+PE + Y++QSD+WS G+ L E+ G P P E Sbjct: 253 DPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDE-- 310 Query: 273 LMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSL 332 EG P + P M L Sbjct: 311 EFCRRLKEGTRMRAPDY--------------TTPEMYQTMLD------------------ 338 Query: 333 EFQDFVNKCLIKNPAERADLKQLMVH 358 C P++R +L+ H Sbjct: 339 --------CWHGEPSQRPTFSELVEH 356 Score = 90.1 bits (222), Expect = 2e-18, Method: Composition-based stats. Identities = 27/129 (20%), Positives = 47/129 (36%), Gaps = 12/129 (9%) Query: 38 EELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKV-----SHKPSGL 92 +EL LDE + L E D + LG G G V + + Sbjct: 6 DELPLDEHCER-----LPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCR 60 Query: 93 VMARKLIHLEIKPAIRNQIIRELQVL-HECNSPYIVGFYGAFYSD-GEISICMEHMDGGS 150 +A K++ + ++ EL++L H + +V GA G + + +E G+ Sbjct: 61 TVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGN 120 Query: 151 LDQVLKKAG 159 L L+ Sbjct: 121 LSTYLRSKR 129 >1CSN-A nrPDB Length = 298 Score = 132 bits (332), Expect = 2e-31, Method: Composition-based stats. Identities = 50/262 (19%), Positives = 95/262 (36%), Gaps = 22/262 (8%) Query: 67 DFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNS-PY 125 ++ +G G+ GV+F+ ++ + +A K R ++L C P Sbjct: 11 HYKVGRRIGEGSFGVIFEGTNLLNNQQVAIKFEPRRSDAPQLRDEYRTYKLLAGCTGIPN 70 Query: 126 IVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR-IPEQILGKVSIAVIKGLTYLREKH 184 + Y + ++ + G SL+ +L GR + + + ++ + + EK Sbjct: 71 V---YYFGQEGLHNVLVIDLL-GPSLEDLLDLCGRKFSVKTVAMAAKQMLARVQSIHEK- 125 Query: 185 KIMHRDVKPSNILVNSRGE-----IKLCDFGVSGQLIDSMANSFV---------GTRSYM 230 +++RD+KP N L+ I + DFG+ D + + GT YM Sbjct: 126 SLVYRDIKPDNFLIGRPNSKNANMIYVVDFGMVKFYRDPVTKQHIPYREKKNLSGTARYM 185 Query: 231 SPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRP 290 S G S + D+ ++G + G P A + + ++ TP R Sbjct: 186 SINTHLGREQSRRDDLEALGHVFMYFLRGSLPWQGLKAATNKQKYE-RIGEKKQSTPLRE 244 Query: 291 RTPGRPLSSYGMDSRPPMAIFE 312 G P Y F+ Sbjct: 245 LCAGFPEEFYKYMHYARNLAFD 266 >4RT7-A nrPDB Length = 415 Score = 132 bits (332), Expect = 3e-31, Method: Composition-based stats. Identities = 52/205 (25%), Positives = 91/205 (44%), Gaps = 16/205 (7%) Query: 113 RELQVLHECNSPYIVGFYG-AFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSI 171 RE+Q+ +S I G +G +F+S+ EI E+ + L++ + + + L + Sbjct: 198 REVQI--HPDSDQISGLHGNSFHSEDEI----EYENQKRLEE-EEDLNVLTFEDLLCFAY 250 Query: 172 AVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRS--- 228 V KG+ +L K +HRD+ N+LV +K+CDFG++ ++ G Sbjct: 251 QVAKGMEFLEFK-SCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPV 309 Query: 229 -YMSPERLQGTHYSVQSDIWSMGLSLVEMAV-GRYPIP--PPDAKELELMFGCQVEGDAA 284 +M+PE L Y+++SD+WS G+ L E+ G P P P DA +L+ Sbjct: 310 KWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPF 369 Query: 285 ETPPRPRTPGRPLSSYGMDSRPPMA 309 + ++ RP Sbjct: 370 YATEEIYIIMQSCWAFDSRKRPSFP 394 Score = 103 bits (256), Expect = 2e-22, Method: Composition-based stats. Identities = 23/118 (19%), Positives = 47/118 (39%), Gaps = 6/118 (5%) Query: 61 GELKDDDFEKISELGAGNGGVV-----FKVSHKPSGLVMARKLIHLEIKPAIRNQIIREL 115 E ++ E LG+G G V + +S + +A K++ + + R ++ EL Sbjct: 60 WEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSEL 119 Query: 116 QVLHEC-NSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIA 172 +++ + + IV GA G I + E+ G L L+ + ++ Sbjct: 120 KMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKE 177 >3HNG-A nrPDB Length = 360 Score = 131 bits (330), Expect = 5e-31, Method: Composition-based stats. Identities = 44/161 (27%), Positives = 66/161 (40%), Gaps = 12/161 (7%) Query: 158 AGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID 217 I + L S V +G+ +L + K +HRD+ NIL++ +K+CDFG++ + Sbjct: 193 KEPITMEDLISYSFQVARGMEFLSSR-KCIHRDLAARNILLSENNVVKICDFGLARDIYK 251 Query: 218 SMANSFVG-TR---SYMSPERLQGTHYSVQSDIWSMGLSLVEMAV-GRYPIPPPDAKELE 272 + G TR +M+PE + YS +SD+WS G+ L E+ G P P E Sbjct: 252 NPDYVRKGDTRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDED- 310 Query: 273 LMFGCQVEGDAAETP----PRPRTPGRPLSSYGMDSRPPMA 309 EG P P RP A Sbjct: 311 -FCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFA 350 Score = 91.7 bits (226), Expect = 6e-19, Method: Composition-based stats. Identities = 27/131 (20%), Positives = 49/131 (37%), Gaps = 12/131 (9%) Query: 38 EELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKV-----SHKPSGL 92 +E+ LDEQ + L E + + LG G G V + P+ Sbjct: 4 DEVPLDEQCER-----LPYDASKWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCR 58 Query: 93 VMARKLIHLEIKPAIRNQIIRELQVLHECNSP-YIVGFYGAFYSD-GEISICMEHMDGGS 150 +A K++ + ++ EL++L +V GA G + + +E+ G+ Sbjct: 59 TVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGN 118 Query: 151 LDQVLKKAGRI 161 L LK + Sbjct: 119 LSNYLKSKRDL 129 >5L2Q-C nrPDB Length = 320 Score = 124 bits (311), Expect = 7e-29, Method: Composition-based stats. Identities = 52/318 (16%), Positives = 102/318 (32%), Gaps = 86/318 (27%) Query: 83 FKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPY-----------IVGFYG 131 + K++ LE + + E Q ++ Y +V +G Sbjct: 33 CLARKDGTDDFYQLKILTLEERGDQGIESQEERQGKMLLHTEYSLLSLLHTQDGVVHHHG 92 Query: 132 AFYS------------------DGEISICMEHMDGGS----------LDQVLKKAGRIPE 163 F I + ++ + L + K R+ E Sbjct: 93 LFQDRTCEIVEDTESSRMVKKMKKRICLVLDCLCAHDFSDKTADLINLQHYVIKEKRLSE 152 Query: 164 QILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGE-IKLCDFGVSGQLID--SMA 220 + + V++ + L +K+ I+HRD+K N+++N R I + +F + L+ + Sbjct: 153 RETVVIFYDVVRVVEALHQKN-IVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEGDLL 211 Query: 221 NSFVGTRSYMSPERLQGTHY-SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQV 279 G+ +Y+SP+ L G Y SD+W++G+ L M G++P Sbjct: 212 KDQRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPFYD-------------- 257 Query: 280 EGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVN 339 P +F + P G S + Sbjct: 258 -------------------------SIPQELFRKIKAAEYTIPE---DGRVSENTVCLIR 289 Query: 340 KCLIKNPAERADLKQLMV 357 K L+ +P +R ++ Sbjct: 290 KLLVLDPQQRLAAADVLE 307 >4L00-A nrPDB Length = 304 Score = 123 bits (309), Expect = 1e-28, Method: Composition-based stats. Identities = 59/308 (19%), Positives = 111/308 (36%), Gaps = 67/308 (21%) Query: 62 ELKDDDFEKISELGAGNGGVVFKVS------HKPSGLVMARKLIHLEIKPAIRN---QII 112 + D + LG G ++ + + + K+I + P+ R+ Sbjct: 21 RILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFF 80 Query: 113 RELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKA-GRIPEQILGKVSI 171 ++ + + +IV YG D E + E ++GG LD + + + KV+ Sbjct: 81 EAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAK 140 Query: 172 AVIKGLTYLREKHKIMHRDVKPSNILVNSRG-------EIKLCDFGVSGQLIDSMANSFV 224 + L+YL +K ++H +V N+L+ G IKL D G+ ++ + Sbjct: 141 QLASALSYLEDK-DLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQ--ECI 197 Query: 225 GTRSYMSPERLQGTH-YSVQSDIWSMGLSLVEMAV-GRYPIPPPDAKELELMFGCQVEGD 282 +++PE ++ + SV +D WS G +L E+ G P+ E E + Sbjct: 198 ERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFY------- 250 Query: 283 AAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCL 342 E+ RP TP E D + +C+ Sbjct: 251 --ESRCRPVTPS------------------------------------CKELADLMTRCM 272 Query: 343 IKNPAERA 350 +P +R Sbjct: 273 NYDPNQRP 280 >6DC0-A nrPDB Length = 292 Score = 122 bits (306), Expect = 2e-28, Method: Composition-based stats. Identities = 48/288 (16%), Positives = 103/288 (35%), Gaps = 60/288 (20%) Query: 82 VFKVSHKPSGLVMARKLIHLE-IKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEIS 140 V + +G + K+ ++ + IR I + I G + + Sbjct: 22 VSRALCIHTGRELRCKVFPIKHYQDKIRPYI-------QLPSHSNITGIVEVILGETKAY 74 Query: 141 ICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVN- 199 + E D G + ++ R+ E+ ++ ++ + + + I+ D+K + + Sbjct: 75 VFFEK-DFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSA-IVLGDLKLRKFVFST 132 Query: 200 -SRGEIKLCDFGVSGQL--IDSMANSFVGTRSYMSPERLQ--GTHYSVQSDIWSMGLSLV 254 R +++L + + D + G +Y+SPE L GT+ +D+WS+G+ L Sbjct: 133 EERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLY 192 Query: 255 EMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELL 314 + VGRYP D P A+F + Sbjct: 193 TLLVGRYPFHDSD---------------------------------------PSALFSKI 213 Query: 315 DYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIK 362 P + S + + + L + P+ER ++++H + + Sbjct: 214 RRGQFCIPEHI-----SPKARCLIRSLLRREPSERLTAPEILLHPWFE 256 >5CEK-A nrPDB Length = 263 Score = 122 bits (306), Expect = 3e-28, Method: Composition-based stats. Identities = 48/288 (16%), Positives = 103/288 (35%), Gaps = 60/288 (20%) Query: 82 VFKVSHKPSGLVMARKLIHLE-IKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEIS 140 V + +G + K+ ++ + IR I + I G + + Sbjct: 25 VSRALCIHTGRELRCKVFPIKHYQDKIRPYI-------QLPSHSNITGIVEVILGETKAY 77 Query: 141 ICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVN- 199 + E D G + ++ R+ E+ ++ ++ + + + I+ D+K + + Sbjct: 78 VFFEK-DFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSA-IVLGDLKLRKFVFST 135 Query: 200 -SRGEIKLCDFGVSGQL--IDSMANSFVGTRSYMSPERLQ--GTHYSVQSDIWSMGLSLV 254 R +++L + + D + G +Y+SPE L GT+ +D+WS+G+ L Sbjct: 136 EERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLY 195 Query: 255 EMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELL 314 + VGRYP D P A+F + Sbjct: 196 TLLVGRYPFHDSD---------------------------------------PSALFSKI 216 Query: 315 DYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIK 362 P + S + + + L + P+ER ++++H + + Sbjct: 217 RRGQFCIPEHI-----SPKARCLIRSLLRREPSERLTAPEILLHPWFE 259 >5USZ-A nrPDB Length = 289 Score = 118 bits (296), Expect = 4e-27, Method: Composition-based stats. Identities = 54/266 (20%), Positives = 101/266 (37%), Gaps = 25/266 (9%) Query: 62 ELKDDDFEKISELGAGNGGVVFKVSHKPSGL-------VMARKLIHLEIKPAIRNQIIRE 114 +++++D LG G +FK + G + K++ + Sbjct: 4 KIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHR-NYSESFFEA 62 Query: 115 LQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR-IPEQILGKVSIAV 173 ++ + + ++V YG E + E + GSLD LKK I +V+ + Sbjct: 63 ASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQL 122 Query: 174 IKGLTYLREKHKIMHRDVKPSNILV--------NSRGEIKLCDFGVS-GQLIDSMANSFV 224 + +L E + ++H +V NIL+ + IKL D G+S L + + Sbjct: 123 AAAMHFLEE-NTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERI 181 Query: 225 GTRSYMSPERLQG-THYSVQSDIWSMGLSLVEMAV-GRYPIPPPDAKELELMFGCQVEGD 282 ++ PE ++ + ++ +D WS G +L E+ G P+ D+ + +L F Sbjct: 182 ---PWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDS-QRKLQFYEDRHQL 237 Query: 283 AAETPPRPRTPGRPLSSYGMDSRPPM 308 A Y D RP Sbjct: 238 PAPKAAELANLINNCMDYEPDHRPSF 263 >6J6I-B nrPDB Length = 351 Score = 117 bits (293), Expect = 8e-27, Method: Composition-based stats. Identities = 39/203 (19%), Positives = 77/203 (37%), Gaps = 17/203 (8%) Query: 94 MARKLIHLEIKPAIRNQIIRELQV-----LHECNSPYIVGFYGAFYSDGEISICMEHMDG 148 K + R+++ +E+ N + G + E + Sbjct: 84 YMIKRFSEDEITGKRHRV-KEVYNDIVLSARMSNHSNFLQLLGCCLEFPFPVLVFEFAEH 142 Query: 149 GSLDQ---VLKKAGR--IPEQILGKVSIAVIKGLTYLREKHK--IMHRDVKPSNILVNSR 201 G+++Q V+ +P + K+ + +TYL I+HRDVKP ++ ++ Sbjct: 143 GAMNQRGGVIVNGEESLLPWSVRLKIGKEIANAVTYLHTAFPKIIIHRDVKPMHVFLDKN 202 Query: 202 GEIKLCDFGVSGQLIDS----MANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMA 257 KL D S L + A +GT Y+ P + + +D++S G+ L+ + Sbjct: 203 WTAKLSDLSFSISLPEGKSRIEAEWVLGTFGYIDPLYHKTCFVTEYTDVYSFGICLLVII 262 Query: 258 VGRYPIPPPDAKELELMFGCQVE 280 G+ I +L+ + E Sbjct: 263 TGKPAIMTISDGDLQGILSLVRE 285 >3REP-A nrPDB Length = 271 Score = 117 bits (293), Expect = 9e-27, Method: Composition-based stats. Identities = 43/267 (16%), Positives = 99/267 (37%), Gaps = 15/267 (5%) Query: 67 DFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYI 126 +++L + G ++K + + +V+ + R+ E L + P + Sbjct: 11 QLNFLTKLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRD-FNEECPRLRIFSHPNV 69 Query: 127 VGFYGAFYSDG--EISICMEHMDGGSLDQVLKKAGRI--PEQILGKVSIAVIKGLTYLRE 182 + GA S ++ M GSL VL + + K ++ + +G+ +L Sbjct: 70 LPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFLHT 129 Query: 183 KHKIMHR-DVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYS 241 ++ R + +++++ ++ ++ + + ++++PE LQ Sbjct: 130 LEPLIPRHALNSRSVMIDEDMTARIS---MADVKFSFQSPGRMYAPAWVAPEALQKKPED 186 Query: 242 V---QSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLS 298 +D+WS + L E+ P D +E+ +EG PP L Sbjct: 187 TNRRSADMWSFAVLLWELVTREVPF--ADLSNMEIGMKVALEGLRPTIPPGISPHVSKLM 244 Query: 299 SYGMDSRP-PMAIFELLDYIVNEPPPK 324 M+ P F+++ I+ + K Sbjct: 245 KICMNEDPAKRPKFDMIVPILEKMQDK 271 >4I94-A nrPDB Length = 300 Score = 115 bits (287), Expect = 4e-26, Method: Composition-based stats. Identities = 53/277 (19%), Positives = 100/277 (36%), Gaps = 44/277 (15%) Query: 81 VVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEIS 140 VV+K + +A K + + P R Q + E + + + + + G Y D E Sbjct: 44 VVYKGKL-ENQRRIAVKRFNRKSWPDSR-QFLEEAKAVGQLRNHRMANLLGCCYEDEERL 101 Query: 141 ICMEHMDGGSLDQVLKKA--GRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILV 198 + E M +L + L + + +V++ + + L Y K + ++ D+ +L Sbjct: 102 LIAEFMPNETLAKHLFHWESQPMKWAMRLRVALHIAQALEYCTSKGRALYHDLNAYRVLF 161 Query: 199 NSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAV 258 + +L FG+ D + S ++ PE L+ + +S I+S G L+++ Sbjct: 162 DDDANPRLSCFGLMKNSRDGKSYST--NLAFTPPEYLRTGRVTPESVIYSFGTLLLDLLS 219 Query: 259 GRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIV 318 G++ IPP A +L Q+ D+ G Sbjct: 220 GKH-IPPSHALDLIRDRNIQMLMDSGLEGQFSSDDG------------------------ 254 Query: 319 NEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQL 355 E ++CL P ER + K L Sbjct: 255 -------------TELIRLASRCLQYEPRERPNPKSL 278 >2PZI-A nrPDB Length = 681 Score = 114 bits (286), Expect = 5e-26, Method: Composition-based stats. Identities = 62/347 (17%), Positives = 128/347 (36%), Gaps = 37/347 (10%) Query: 61 GELKDDDFEKISELGAGNGGVVFKVSHKP-SGLVMARKLIHLEIKPAIRNQIIRELQVLH 119 G++ +E + G G ++ + +G + K + + + E Q L Sbjct: 75 GDIVAGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAERQFLA 134 Query: 120 ECNSPYIVGFYGAFYSDGEI-----SICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVI 174 E P IV + I ME++ G SL + K ++P + ++ Sbjct: 135 EVVHPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSLKR--SKGQKLPVAEAIAYLLEIL 192 Query: 175 KGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPER 234 L+YL +++ D+KP NI++ ++KL D G ++ + GT + +PE Sbjct: 193 PALSYLHSI-GLVYNDLKPENIMLTEE-QLKLIDLGAVSRI--NSFGYLYGTPGFQAPEI 248 Query: 235 LQGTHYSVQSDIWSMGLSLVEMAVGRYP-----IPPPDAKELELMFGCQVEGDAAETPPR 289 ++ +V +DI+++G +L + P ++ ++ G Sbjct: 249 VRTGP-TVATDIYTVGRTLAAL-TLDLPTRNGRYVDGLPEDDPVLKTYDSYGRLLRRAID 306 Query: 290 PRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKN---- 345 P R ++ M ++ + E++ P P L + +FS F L+ + Sbjct: 307 PDPRQRFTTAEEMSAQLTGVLREVVAQDTGVPRPGLST-IFSPSRSTFGVDLLVAHTDVY 365 Query: 346 -----PAERADLKQ---LMVHAFIKRSDAEEVDFAGWLCSTIGLNQP 384 AE+ + + + + D A + L+QP Sbjct: 366 LDGQVHAEKLTANEIVTALSVPLV-----DPTDVAASVLQATVLSQP 407 >4Y12-A nrPDB Length = 375 Score = 114 bits (284), Expect = 1e-25, Method: Composition-based stats. Identities = 42/202 (20%), Positives = 86/202 (42%), Gaps = 13/202 (6%) Query: 61 GELKDDDFEKISELGAGNGGVVFKVSHKP-SGLVMARKLIHLEIKPAIRNQIIRELQVLH 119 G++ +E + G G ++ + +G + K + + + E Q L Sbjct: 114 GDIVAGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAERQFLA 173 Query: 120 ECNSPYIVGFYGAFYSDGEI-----SICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVI 174 E P IV + I ME++ G SL + K ++P + ++ Sbjct: 174 EVVHPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSLKR--SKGQKLPVAEAIAYLLEIL 231 Query: 175 KGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPER 234 L+YL +++ D+KP NI++ ++KL D G ++ + GT + +PE Sbjct: 232 PALSYLHSI-GLVYNDLKPENIMLTEE-QLKLIDLGAVSRI--NSFGYLYGTPGFQAPEI 287 Query: 235 LQGTHYSVQSDIWSMGLSLVEM 256 ++ +V +DI+++G +L + Sbjct: 288 VRTGP-TVATDIYTVGRTLAAL 308 >5X1R-A nrPDB Length = 302 Score = 112 bits (279), Expect = 4e-25, Method: Composition-based stats. Identities = 44/268 (16%), Positives = 99/268 (36%), Gaps = 28/268 (10%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARK--------LIHLEIKPAIRNQ------- 110 ++FE +G G G+V++ +A K + ++ +R + Sbjct: 21 NEFEIQEAIGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAKRNDDLSIGLRGERFGKTFQ 80 Query: 111 -----IIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQV-LKKAGRIPEQ 164 I+E ++L + P ++ + +G + + G +L + ++ +I E Sbjct: 81 AGLNSFIQEARLLARFSHPGLLHVLRFWEENGTAYMGTQFYSGTTLKNLQAQQPEKIDEA 140 Query: 165 ILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA--NS 222 + ++ + + + ++ +HRD+ NI + L DFG + + I +++ Sbjct: 141 WIRRLLPPLFSAINTIHQE-GYLHRDISLDNIQIQESQLPVLLDFGSARKEIGNLSDETE 199 Query: 223 FVGTRSYMSPERL---QGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQV 279 V + E+ +DI+++G L + VG P P + +E + Sbjct: 200 IVLKPGFAPIEQYTENSDGEQGPWTDIYALGAVLHTLIVGSPP-PVSVVRSIEDSYQPLT 258 Query: 280 EGDAAETPPRPRTPGRPLSSYGMDSRPP 307 E A P + + RP Sbjct: 259 ERRPAGYSPELLRTVDRALALKPEDRPQ 286 >5C01-A nrPDB Length = 342 Score = 109 bits (273), Expect = 2e-24, Method: Composition-based stats. Identities = 50/235 (21%), Positives = 87/235 (37%), Gaps = 16/235 (6%) Query: 85 VSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICME 144 + L + K++ ++ + + ++ +G E + E Sbjct: 101 GRDRGQELRVVLKVLDPSHHDIA-LAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTE 159 Query: 145 HMDGGSLDQVLKK-AGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRG- 202 +++ G LD L++ G +P V+ + L+YL K+ ++H +V NIL+ G Sbjct: 160 YVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKN-LVHGNVCGRNILLARLGL 218 Query: 203 ------EIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQG--THYSVQSDIWSMGLSLV 254 IKL D GV L V +++PE L G S D W G +L+ Sbjct: 219 AEGTSPFIKLSDPGVG--LGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLL 276 Query: 255 EMAV-GRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPM 308 E+ G P+ E E + Q + P+ T +Y RP Sbjct: 277 EICFDGEAPLQSRSPSEKEHFYQRQHR-LPEPSCPQLATLTSQCLTYEPTQRPSF 330 >4WOV-A nrPDB Length = 317 Score = 109 bits (272), Expect = 2e-24, Method: Composition-based stats. Identities = 50/235 (21%), Positives = 87/235 (37%), Gaps = 16/235 (6%) Query: 85 VSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICME 144 + L + K++ ++ + + ++ +G E + E Sbjct: 78 GRDRGQELRVVLKVLDPSHHDIA-LAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTE 136 Query: 145 HMDGGSLDQVLKK-AGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRG- 202 +++ G LD L++ G +P V+ + L+YL K+ ++H +V NIL+ G Sbjct: 137 YVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKN-LVHGNVCGRNILLARLGL 195 Query: 203 ------EIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQG--THYSVQSDIWSMGLSLV 254 IKL D GV L V +++PE L G S D W G +L+ Sbjct: 196 AEGTSPFIKLSDPGVG--LGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLL 253 Query: 255 EMAV-GRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPM 308 E+ G P+ E E + Q + P+ T +Y RP Sbjct: 254 EICFDGEAPLQSRSPSEKEHFYQRQHR-LPEPSCPQLATLTSQCLTYEPTQRPSF 307 >5UV4-A nrPDB Length = 311 Score = 108 bits (270), Expect = 4e-24, Method: Composition-based stats. Identities = 41/203 (20%), Positives = 83/203 (40%), Gaps = 15/203 (7%) Query: 72 SELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGF-- 129 +G G +K + +G ++ K + + + + RE++ L P +V Sbjct: 31 EIIGRSCHGTSYKATL-DNGYMLTVKWLKEGFAKS-KKEFSREIKKLGSVRHPNLVPLRG 88 Query: 130 YGAFYSDGEISICMEHMDGGSLDQVLKKAG-----RIPEQILGKVSIAVIKGLTYLREKH 184 Y + E + ++ D SL L + + ++I + + L YL + Sbjct: 89 YYWGPKEHERIMISDYADATSLSTYLSEFDERNLPPLSAGQRLNIAIDIARCLDYLHNER 148 Query: 185 KIMHRDVKPSNILV-NSRGEIKLCDFGVSGQLIDSMANSFV---GTRSYMSPERLQGTH- 239 I H ++K SN+L+ NS + D+ + + V G Y PE + Sbjct: 149 VIPHGNIKSSNVLIQNSTPSALVTDYSLHRLMTPIGMAEQVLNAGALGYSPPEFSSTSKP 208 Query: 240 -YSVQSDIWSMGLSLVEMAVGRY 261 S++SD+++ G+ L+E+ G+ Sbjct: 209 CPSLKSDVYAFGVILLELLTGKI 231 >4JRN-A nrPDB Length = 372 Score = 105 bits (262), Expect = 4e-23, Method: Composition-based stats. Identities = 58/332 (17%), Positives = 100/332 (30%), Gaps = 92/332 (27%) Query: 74 LGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRN--QIIRELQVLHECNS-------- 123 LG+G V++ + + +A K+ E +P + RE + Sbjct: 76 LGSGGFATVYEATDVETNEELAVKVFMSEKEPTDETMLDLQRESSCYRNFSLAKTAKDAQ 135 Query: 124 -------PYIVGFYGAFYSDGEISI--CMEHMDG---------GSLDQVLK--------K 157 P V + E+ I + + +V+ Sbjct: 136 ESCRFMVPSDVVMLEGQPASTEVVIGLTTRWVPNYFLLMMRAEADMSKVISWVFGDASVN 195 Query: 158 AGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID 217 + +S IK + + + I+H D+KP+N L+ G + L DFG I+ Sbjct: 196 KSEFGLVVRMYLSSQAIKLVANV-QAQGIVHTDIKPANFLLLKDGRLFLGDFGTYR--IN 252 Query: 218 SMANSFVGTRSYMSPER---LQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELM 274 + +GT Y PER G Y+ +D W +G++L + P P + Sbjct: 253 NSVGRAIGTPGYEPPERPFQATGITYTFPTDAWQLGITLYCIWCKERPTPADGIWDYLHF 312 Query: 275 FGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEF 334 C P TP Sbjct: 313 ADC------------PSTP--------------------------------------ELV 322 Query: 335 QDFVNKCLIKNPAERADLKQLMVHAFIKRSDA 366 QD + L ++P +R Q + A K D+ Sbjct: 323 QDLIRSLLNRDPQKRMLPLQALETAAFKEMDS 354 >5UU1-A nrPDB Length = 324 Score = 100 bits (250), Expect = 8e-22, Method: Composition-based stats. Identities = 40/232 (17%), Positives = 98/232 (42%), Gaps = 30/232 (12%) Query: 62 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPA-------------IR 108 +++ + + ++G+G G+++ AR ++ +E + + Sbjct: 12 DMEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAK 71 Query: 109 NQIIRELQVLHECNSPYIVGFYGAFYSD----GEISICMEHMDGGSLDQVLKKAGRIPEQ 164 I++ + + I FYG+ ++ + ME + G L ++ + G + Sbjct: 72 KDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERL-GIDLQKISGQNGTFKKS 130 Query: 165 ILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILV--NSRGEIKLCDFGVS---------G 213 + ++ I ++ L Y+ E ++ +H D+K +N+L+ + ++ L D+G+S Sbjct: 131 TVLQLGIRMLDVLEYIHE-NEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNGNHK 189 Query: 214 QLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPP 265 Q ++ GT + S + +G S +SD+ +G ++ G+ P Sbjct: 190 QYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQ 241 >5CLR-A nrPDB Length = 451 Score = 86.7 bits (213), Expect = 2e-17, Method: Composition-based stats. Identities = 43/193 (22%), Positives = 77/193 (39%), Gaps = 19/193 (9%) Query: 83 FKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISIC 142 FKV G K + ++ + + E L + +VG + + I Sbjct: 96 FKVYALDDGKTYFLKSVKIDAESL--TEFTNEKDTLSKL--GRLVGTFFNEQTQVH-YIL 150 Query: 143 MEHMDGGSLDQVLKKAGRIPE-----QILGKVSIAVIKGLTYLREKHKIMHRDVKPSNIL 197 + G L + K A + + + I+V + E ++HRD+KP NI+ Sbjct: 151 TTFIKGIDLSRY-KNALPLNVNLKHFWEVLGIMISVCHQVKQFHEL-GLIHRDLKPGNIM 208 Query: 198 VNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTH---YSVQSDIWSMGLSLV 254 +++ + L DFG S + S+ GT SY++PE +S SD++++ SL Sbjct: 209 LDADMQCHLVDFGSSSSDKEPKPASW-GTASYLAPELNAQEDFIAFSQVSDLFALAYSLD 267 Query: 255 EMAVGRYPIPPPD 267 E+ P Sbjct: 268 ELFN---PFRQVK 277 >2RSV-A nrPDB Length = 403 Score = 85.9 bits (211), Expect = 3e-17, Method: Composition-based stats. Identities = 47/312 (15%), Positives = 114/312 (36%), Gaps = 43/312 (13%) Query: 47 RKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLV-----MARKLIHL 101 ++ L + + ++ +++ +G G G ++ S V K+ Sbjct: 23 KRHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPS 82 Query: 102 EIKP----------AIRNQIIRELQVLHECNSPYIVGFYGAFYSDG----EISICME-HM 146 + P A + + I++ + + ++G+ D + M+ Sbjct: 83 DNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF- 141 Query: 147 DGGSLDQVLK-KAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVN--SRGE 203 G L ++ + A R + + ++S+ ++ L Y+ E H+ +H D+K SN+L+N + + Sbjct: 142 -GSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHE-HEYVHGDIKASNLLLNYKNPDQ 199 Query: 204 IKLCDFGVS---------GQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLV 254 + L D+G++ + + GT + S + G S + D+ +G ++ Sbjct: 200 VYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMI 259 Query: 255 EMAVGRYPIPPP--------DAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRP 306 + G P D+K + +P + + + + Sbjct: 260 QWLTGHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYT 319 Query: 307 PMAIFELLDYIV 318 ++E L I+ Sbjct: 320 EKPLYENLRDIL 331 >2LAV-A nrPDB Length = 361 Score = 85.1 bits (209), Expect = 4e-17, Method: Composition-based stats. Identities = 47/312 (15%), Positives = 114/312 (36%), Gaps = 43/312 (13%) Query: 47 RKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLV-----MARKLIHL 101 ++ L + + ++ +++ +G G G ++ S V K+ Sbjct: 16 KRHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPS 75 Query: 102 EIKP----------AIRNQIIRELQVLHECNSPYIVGFYGAFYSDG----EISICME-HM 146 + P A + + I++ + + ++G+ D + M+ Sbjct: 76 DNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF- 134 Query: 147 DGGSLDQVLK-KAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVN--SRGE 203 G L ++ + A R + + ++S+ ++ L Y+ E H+ +H D+K SN+L+N + + Sbjct: 135 -GSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHE-HEYVHGDIKASNLLLNYKNPDQ 192 Query: 204 IKLCDFGVS---------GQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLV 254 + L D+G++ + + GT + S + G S + D+ +G ++ Sbjct: 193 VYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMI 252 Query: 255 EMAVGRYPIPPP--------DAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRP 306 + G P D+K + +P + + + + Sbjct: 253 QWLTGHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYT 312 Query: 307 PMAIFELLDYIV 318 ++E L I+ Sbjct: 313 EKPLYENLRDIL 324 >5OAT-A nrPDB Length = 411 Score = 84.0 bits (206), Expect = 1e-16, Method: Composition-based stats. Identities = 55/347 (15%), Positives = 106/347 (30%), Gaps = 74/347 (21%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPS-----GLVMARKLIHLEIKPAIRNQIIR------- 113 +D + G GVV+ K A K++ +I++ Sbjct: 11 NDLSLGKPIAKGTNGVVYSAKVKDDETDDNKYPFALKMMFNYDIQENSMEILKAMYRETV 70 Query: 114 --------------ELQVLHECNS----PYIVGFYGAFYS------------DGE----- 138 E+++ + P IV + F +GE Sbjct: 71 PARMYYSNHDLNNWEIELANRRKHLPPHPNIVAIFSVFTDLYPAALPPRLHPEGEGRNMS 130 Query: 139 ISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILV 198 + + M+ D +L L A + + +++G+ ++ H I HRD+K N+L+ Sbjct: 131 LFLLMKRYDC-NLQSFLSTA--PSTRTSLLLLAQLLEGVAHM-TAHGIAHRDLKSDNLLL 186 Query: 199 N----SRGEIKLCDF---------GVSGQLIDSMANSFVGTRSYMSPERLQGTH------ 239 + + + DF G+S + T M+PE + Sbjct: 187 DTSEPESPILVISDFGCCLADKTNGLSLPYTSYEMDKGGNTAL-MAPEIICQKPGTFSVL 245 Query: 240 -YSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLS 298 YS ++D+W++G E+ P P + + E P + L Sbjct: 246 NYS-KADLWAVGAIAYEIFNCHNPFYGPSRLKNFNYKEGDLPKLPDEVPTVIQALVANLL 304 Query: 299 SYGMDSR-PPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIK 344 + R P + + P L G+ + + L Sbjct: 305 KRNPNKRLDPEVAANVCQLFLWAPSTWLKPGLKVPTSGEILQWLLSL 351 >6EQI-C nrPDB Length = 433 Score = 81.3 bits (199), Expect = 8e-16, Method: Composition-based stats. Identities = 50/299 (16%), Positives = 93/299 (31%), Gaps = 78/299 (26%) Query: 66 DDFEKISELGAGNGGVVFKVSHKPSG-----LVMARKLI----HLEIKPAIRNQIIRE-- 114 D+ + + G VV+ K +A K++ AI + RE Sbjct: 15 DELDLGEPIAKGCNAVVYSAKLKNVQSNKLAHQLAVKMMFNYDVESNSTAILKAMYRETV 74 Query: 115 -------------LQVLHECN-----SPYIVGFYGAFYS--------------------- 135 ++ + + P IV Y F Sbjct: 75 PAMSYFFNQNLFNIENISDFKIRLPPHPNIVRMYSVFADRIPDLQCNKQLYPEALPPRIN 134 Query: 136 ------DGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHR 189 + + + M+ D +L + L+ + + +++ + ++ H I HR Sbjct: 135 PEGSGRNMSLFLVMKRYDC-TLKEYLRDKTP-NMRSSILLLSQLLEAVAHM-NIHNISHR 191 Query: 190 DVKPSNILV-----NSRGEIKLCDFGVS--------GQLIDSMANSFVGTRSYMSPERLQ 236 D+K NILV ++ I + DFG S G R+ M+PE Sbjct: 192 DLKSDNILVDLSEGDAYPTIVITDFGCCLCDKQNGLVIPYRSEDQDKGGNRALMAPEIAN 251 Query: 237 GTHYS------VQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPR 289 + +SD+W++G E+ P K L + + + +T P Sbjct: 252 AKPGTFSWLNYKKSDLWAVGAIAYEIFNIDNPFYDKTMKLLSKSYKEEDLPELPDTIPF 310 >6EAS-A nrPDB Length = 308 Score = 79.7 bits (195), Expect = 2e-15, Method: Composition-based stats. Identities = 46/322 (14%), Positives = 109/322 (33%), Gaps = 59/322 (18%) Query: 46 QRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARK----LIHL 101 Q+ + + K+ E +DF I +G+ + +++K + SG+ +A Sbjct: 22 QKAFVTGVPSLKRSELETACEDFSNI--IGSTSTCMLYKGTL-SSGVEIAVASSLVTSAK 78 Query: 102 EIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEI--SICMEHMDGGSLDQVL--KK 157 + +Q +++ L + + + G + + E+ G+L + L ++ Sbjct: 79 DWSKENESQYRKKITNLSKVSHKNFMNLLGYCEEEHPFTRVMVFEYAPNGTLFEHLHVRE 138 Query: 158 AGRIPEQILGKVSIAVIKGLTYLRE-KHKIMHRDVKPSNILVNSRGEIKLCDFGV---SG 213 A ++ ++S+ + L ++ + + R+ + + + K+ D + Sbjct: 139 AEKLDWMARLRISMGIAYCLEHMHQLQTPAALRNFDSTTVYLTDDFAAKVSDLEFWNDAK 198 Query: 214 QLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELEL 273 + N + M E + G+ L+E+ GR P D Sbjct: 199 GHNSTTNNELAFSPD-M--EDIVRK----------YGMVLLEILTGRVPSSEDDG----- 240 Query: 274 MFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLE 333 P R M + EL+D + P + Sbjct: 241 --------------PLENWVSRYFEG-------GMRLEELIDPSIGFFPEDTARALC--- 276 Query: 334 FQDFVNKCLIKNPAERADLKQL 355 + V C+ ++P +R +K++ Sbjct: 277 --EVVRSCIDRDPKKRPQMKEV 296 >5DMZ-A nrPDB Length = 365 Score = 75.5 bits (184), Expect = 4e-14, Method: Composition-based stats. Identities = 46/299 (15%), Positives = 97/299 (32%), Gaps = 43/299 (14%) Query: 74 LGAGNGGVVFKVS-----HKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHEC----NSP 124 LG G V++ + + K+ KPA + Q++ Sbjct: 73 LGEGAFAQVYEATQGDLNDAKNKQKFVLKV----QKPANPWEFYIGTQLMERLKPSMQHM 128 Query: 125 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQIL-GKVSIAVIKGLTYL--- 180 + + FY A + E G+L + PE+++ + I+ + Y+ Sbjct: 129 F-MKFYSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEKVMPQGLVISFAMRMLYMIEQ 187 Query: 181 REKHKIMHRDVKPSNILVNSRGE-----------IKLCDFGVSGQL----IDSMANSFVG 225 +I+H D+KP N ++ + + L D G S + ++ + Sbjct: 188 VHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMKLFPKGTIFTAKCE 247 Query: 226 TRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAE 285 T + E L ++ Q D + + ++ M G Y K C+ EG Sbjct: 248 TSGFQCVEMLSNKPWNYQIDYFGVAATVYCMLFGTY------MKVKNEGGECKPEGLFRR 301 Query: 286 TPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIK 344 P + + +LL + K+ ++ + + N+ ++ Sbjct: 302 LPHLDMWNEFFHVMLNIPDCHHLPSLDLLRQKL----KKVFQQHYTNKIRALRNRLIVL 356 >4IX6-A nrPDB Length = 350 Score = 69.7 bits (169), Expect = 2e-12, Method: Composition-based stats. Identities = 56/347 (16%), Positives = 103/347 (29%), Gaps = 95/347 (27%) Query: 74 LGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIR-ELQVLHECNSPY----IVG 128 LG+GN G VF+ K V+ L + + +++ E+ V + Sbjct: 28 LGSGNFGTVFRGVFKGDQDVV---LKNAKADVMAAEELLECEMDVNYHV-HANAKGTCAR 83 Query: 129 FYGAFY----SDGEIS--ICME---HM---DGGSLDQVLKKAGRIPEQIL---------- 166 F G GEI E M +G + + L + G P Sbjct: 84 FMGCIELGAKDGGEIYNGTLTEGLWLMWANEGENTVEALMRRGTAPLATAMACADATELG 143 Query: 167 --GKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSR--GEIKLCDFGVSG------QLI 216 K ++ L L E ++HRDVKP+N++ + G +KL D G + + + Sbjct: 144 VTKKAMRELLGSLARLHE-CGVVHRDVKPANLIAAEKDGGVLKLIDLGAAALCLPLPETL 202 Query: 217 DSMANSFVGTRSY--------MSP--------------ERLQGTHYSVQSDIWSMGLSLV 254 + Y + P E + + WS G ++ Sbjct: 203 NYYPGDGPADPRYAKADELYLLPPGSPRPTKDNAAKLWEAHKPDRFDS----WSAGCVML 258 Query: 255 EMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELL 314 ++AV G + + + G ++++ + + Sbjct: 259 QLAV----------------VGLRTDAGLERFLADYKAVGYDVNAFRGEKSGEYGTMDFA 302 Query: 315 DYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFI 361 N D + + RA + + HAF Sbjct: 303 ALDANGGA-----------GWDLCQRLMEAERDARASCEAALSHAFF 338 >6G4J-A nrPDB Length = 315 Score = 68.6 bits (166), Expect = 5e-12, Method: Composition-based stats. Identities = 33/161 (20%), Positives = 63/161 (39%), Gaps = 23/161 (14%) Query: 61 GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE 120 G+ + + +LG G G+V+ S +A K+ + I E+ VL Sbjct: 21 GKWNGNTYTLRKQLGKGANGIVYLAE--TSDGHVALKVSDDSLS------ITSEVNVLKS 72 Query: 121 CNSPYIVGFYGAFYSDGEISI----------CMEHMDGGSLDQVLKKAGRIPEQILGKVS 170 + V +F+ + I ME++ G L + + G + + + Sbjct: 73 FSKAQSVTMGPSFFDTDDAYIPSANTKVSFYAMEYIKGPLLLKYVSDKGA---EWIPVLM 129 Query: 171 IAVIKGLTYLREKHKIMHRDVKPSNILVNS-RGEIKLCDFG 210 I ++ L+ L ++ I D+KP N++V I+ D G Sbjct: 130 IQLLSSLSVLHQQGWIF-GDLKPDNLIVTGPPARIRCIDVG 169 >5GZA-A nrPDB Length = 290 Score = 67.0 bits (162), Expect = 1e-11, Method: Composition-based stats. Identities = 37/209 (17%), Positives = 68/209 (32%), Gaps = 38/209 (18%) Query: 69 EKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVG 128 ++ +G G V+ + G +A ++ + + L +L S ++V Sbjct: 28 RRVKLIGQGAVKKVYLSEWQ--GQKVALSVLS---SDQYADDFLHGLSMLRALQSSHVVT 82 Query: 129 FYGAFYSDGEISICMEHMDGGS---LDQVL---KKAGRIPEQILGKVSIAVIKGLTYLRE 182 G D E+ GS LD L + R +++I + L YL Sbjct: 83 LVGVCEEDA--VFVTEYHPLGSVLTLDTTLAQERYRWRNSWHTRLQLAIDYVAFLAYLHS 140 Query: 183 KHKIMHRDVKPSN--------ILVNSRGEIKLCDFGVSGQLIDSMANSFVG----TRSYM 230 + R + SN L+ S + D ++ G T ++ Sbjct: 141 SPAGI-RVMCDSNDLHKTLSQFLLASDMRLLANDLDALPEVEKGGLGVKCGHHELTGDFV 199 Query: 231 SPERL------------QGTHYSVQSDIW 247 +PE+L Y ++DIW Sbjct: 200 APEQLWPYGEDFSFSDEAMPGYDEKTDIW 228 >5GZ9-A nrPDB Length = 305 Score = 67.0 bits (162), Expect = 2e-11, Method: Composition-based stats. Identities = 43/218 (19%), Positives = 77/218 (35%), Gaps = 41/218 (18%) Query: 62 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHEC 121 E + ++ +G G VF K +A + + ++ + LQ+L Sbjct: 30 EELRTEVRQLKRVGEGAVKRVFLSEWKE--HKVALSRL---TRLEMKEDFLHGLQMLKSL 84 Query: 122 NSPYIVGFYGAFYSDGEISICMEHMDGGSLDQV-----LKKAGRI-PEQILGKVSIAVIK 175 S ++V G DG I E+ GSL + L K + Q ++++ + Sbjct: 85 QSEHVVTLVGYCEEDGT--ILTEYHPLGSLSNLEETLQLSKYQDVNTWQHRLQLAMEYVS 142 Query: 176 GLTYLREKHKIMHRDVKPSN--------ILVNSRGEIKLCDFGVSGQLIDSMANSF--VG 225 + YL + R + SN L+ S I D + L+D + G Sbjct: 143 IINYLHHS-PLGTRVMCDSNDLPKTLSQYLLTSNFSIVANDLD-ALPLVDHDSGVLIKCG 200 Query: 226 TRS----YMSPERL------------QGTHYSVQSDIW 247 R +++PE+L Y+ + DIW Sbjct: 201 HRELHGDFVAPEQLWPYGEDTPFQDDLMPSYNEKVDIW 238 >4AZW-A nrPDB Length = 471 Score = 66.2 bits (160), Expect = 2e-11, Method: Composition-based stats. Identities = 31/137 (22%), Positives = 57/137 (41%), Gaps = 15/137 (10%) Query: 79 GGV--VFK--VSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIV-GFYGAF 133 G V K P G++ A E ++++ E++ L + + + Sbjct: 258 FGEDYVCKFFYYDMPHGILTA------EESQRNKHELHNEIKFLTQPPAGFDAPAVLAHG 311 Query: 134 YSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKP 193 + + ME + G L +L I K+ ++++ L L EK H DV+P Sbjct: 312 ENAQSGWLVMEKLPGRLLSDMLAAGEEID---REKILGSLLRSLAAL-EKKGFWHDDVRP 367 Query: 194 SNILVNSRGEIKLCDFG 210 N++V++R +L DFG Sbjct: 368 WNVMVDARQHARLIDFG 384 >4OAU-C nrPDB Length = 699 Score = 65.9 bits (159), Expect = 3e-11, Method: Composition-based stats. Identities = 47/276 (17%), Positives = 93/276 (33%), Gaps = 35/276 (12%) Query: 80 GVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECN-SPYIVGFYGAFYSDGE 138 G ++ + +A K E P + RE+ L + ++V FYG+ G Sbjct: 357 GGIYLGFY--EKQEVAVKTF-CEGSP----RAQREVSCLQSSRENSHLVTFYGSESHRGH 409 Query: 139 ISICMEHMDGGSLD---QVLKKAGRIPEQI--LGKVSIAVIKGLTYLREKHKIMHRDVKP 193 + +C+ + +L+ V + E+ V ++ K + L H+D++P Sbjct: 410 LFVCVTLCEQ-TLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQP 468 Query: 194 SNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMG-LS 252 NIL++S+ L DF S + E + D+ +G L Sbjct: 469 QNILIDSKKAAHLADFDKSIKWAGDPQ------------EV--------KRDLEDLGRLV 508 Query: 253 LVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFE 312 L + G A+ E + + + + R PG + D + Sbjct: 509 LYVVKKGSISFEDLKAQSNEEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWT 568 Query: 313 LLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAE 348 S + + + + + + L P+E Sbjct: 569 WESRYRTLRNVGNESDIKTRKSESEILRLLQPGPSE 604 >4AZV-A nrPDB Length = 569 Score = 65.5 bits (158), Expect = 4e-11, Method: Composition-based stats. Identities = 31/137 (22%), Positives = 56/137 (40%), Gaps = 15/137 (10%) Query: 79 GGV--VFK--VSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIV-GFYGAF 133 G V K P G++ A E + ++ E++ L + + + Sbjct: 258 FGEDYVCKFFYYDMPHGILTA------EESQRNKYELHNEIKFLTQPPAGFDAPAVLAHG 311 Query: 134 YSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKP 193 + + ME + G L +L I K+ ++++ L L EK H DV+P Sbjct: 312 ENAQSGWLVMEKLPGRLLSDMLAAGEEID---REKILGSLLRSLAAL-EKQGFWHDDVRP 367 Query: 194 SNILVNSRGEIKLCDFG 210 N++V++R +L DFG Sbjct: 368 WNVMVDARQHARLIDFG 384 >4CI6-B nrPDB Length = 643 Score = 64.7 bits (156), Expect = 7e-11, Method: Composition-based stats. Identities = 53/327 (16%), Positives = 104/327 (31%), Gaps = 62/327 (18%) Query: 88 KPSGLVMARKLIHLEIKPAIRNQIIRELQVLHEC-----NSPYIVGFYG---AFYSDGEI 139 K ++A K+ + + EL+ P + +G Y + Sbjct: 66 KDKQRLVA-KI----ERSIAEGHLFAELEAYKHIYKTAGKHPNLANVHGMAVVPYGNRYY 120 Query: 140 S-ICMEHMDG-------GSLDQVLKKAGRIPEQ---ILGKVSIAVIKGLTYLREKHKIMH 188 + M+ +DG SL K+ E + ++ ++ +L K I+H Sbjct: 121 YALLMDEVDGWRCSDTLRSLADSWKQGKINSEAYWGTIKFIAHRLLDVTNHL-AKAGIVH 179 Query: 189 RDVKPSNILVN-SRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGT-HYSVQSDI 246 D+KP N++ + + GE + D G+ + F T S+ +PE G S +SD+ Sbjct: 180 NDIKPGNVVFDRASGEPVVIDLGLHSR-SGEQPKGF--TESFKAPELGVGNLGASEKSDV 236 Query: 247 WSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRP 306 + L + + G +P + Sbjct: 237 F---LVVSTLLHGIEGFEKDPE-------------------------IKPNQGLRFITSE 268 Query: 307 PMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDA 366 P + + Y ++ P ++ F+ L + R D + +H F+ Sbjct: 269 PAHVMDENGYPIHRPGIAGVETAYTR----FITDILGVSADSRPDSNEARLHEFLSDGTI 324 Query: 367 EEVDFAGWLCSTIGLNQPSTPTHAAGV 393 +E L T+ PT + Sbjct: 325 DEESAKQILKDTLTGEMSPLPTDVRRI 351 >4O1O-A nrPDB Length = 717 Score = 63.2 bits (152), Expect = 2e-10, Method: Composition-based stats. Identities = 47/363 (12%), Positives = 104/363 (28%), Gaps = 106/363 (29%) Query: 44 EQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEI 103 E + + K+ D++++ G ++ + +A K Sbjct: 328 EALKHLHRIWRPMIGKLKIFIDEEYKIADT-AEGG---IYLGLY--EDQEVAVKRFSEGS 381 Query: 104 KPAIRNQIIRELQVLHECN-SPYIVGFYGAFYSDGEISICMEHMDGGSLDQVL--KKAGR 160 +E+ L + +V FYG+ + +C+ + +L + L + Sbjct: 382 TRG-----QQEVSCLQSSRANDNVVTFYGSESDGSCLHVCLALCEY-TLQEHLANHRGDA 435 Query: 161 IPEQI---LGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID 217 +P + + ++ K + L + H+D++P NIL++S+ L DF S + + Sbjct: 436 VPNEEDESARNILSSLFKAIGELH-RSGYSHQDLQPQNILIDSKNGTFLADFDKSIKWAE 494 Query: 218 SMANSFVGTRSYMSPERLQGTHYSVQSDIWSMG-LSLVEMAVGRYPIPPPDAKELELMFG 276 ++ D+ ++G L L + G + E Sbjct: 495 DPQK--------------------IKRDLEALGLLVLYVVKKGDISFETLKNQSFE---- 530 Query: 277 CQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQD 336 ++ G E +D Sbjct: 531 -----------------------------------------------EVIQGSPDEETRD 543 Query: 337 FVNKCLIK--NPAERADLKQLMVHAFIKRSDAE-----------EVDFAGWLCSTIGLNQ 383 ++ N +R L+ H F ++ ++ + L Q Sbjct: 544 LIHHLFHPGDNVEDRLSS--LLAHPFFWSWESRYRTLRDVGNESDIKTRNQNSRILQLLQ 601 Query: 384 PST 386 P T Sbjct: 602 PGT 604 >2JII-A nrPDB Length = 352 Score = 58.9 bits (141), Expect = 3e-09, Method: Composition-based stats. Identities = 39/217 (17%), Positives = 82/217 (37%), Gaps = 19/217 (8%) Query: 134 YSDGEISICMEHMDGGSLDQVLK--KAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDV 191 + D + + + G SL L + E+ + +V+ ++ L +L E ++ +H +V Sbjct: 128 HQDKYRFLVLPSL-GRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHE-NEYVHGNV 185 Query: 192 KPSNILVN--SRGEIKLCDFGVS-GQLIDSMANSFV--------GTRSYMSPERLQGTHY 240 NI V+ + ++ L +G + ++V G ++S + +G Sbjct: 186 TAENIFVDPEDQSQVTLAGYGFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMDLHKGCGP 245 Query: 241 SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY 300 S +SD+ S+G +++ G P ++M Q + P P Sbjct: 246 SRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQ---KFVDKPGPFVGPCGHWIRP 302 Query: 301 GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDF 337 + + + L Y P L + + +L QD Sbjct: 303 SETLQKYLKVVMALTYEEKPPYAMLRNNLEAL-LQDL 338 >6G38-A nrPDB Length = 357 Score = 57.8 bits (138), Expect = 7e-09, Method: Composition-based stats. Identities = 30/181 (16%), Positives = 57/181 (31%), Gaps = 51/181 (28%) Query: 63 LKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE-------IKPAIRNQIIREL 115 L + ++ ++G G G VF+ + +A K+I +E +I+ E+ Sbjct: 38 LPTEKLQRCEKIGEGVFGEVFQTIADHT--PVAIKIIAIEGPDLVNGSHQKTFEEILPEI 95 Query: 116 QVLHE-----------------CNSPYIVG------FYGAFYS----------------D 136 + E NS + V A+ D Sbjct: 96 IISKELSLLSGEVCNRTEGFIGLNSVHCVQGSYPPLLLKAWDHYNSTKGSANDRPDFFKD 155 Query: 137 GEISICMEHMDGG-SLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSN 195 ++ I +E GG L+Q+ K + + + L + HRD+ N Sbjct: 156 DQLFIVLEFEFGGIDLEQMRTKLSSL--ATAKSILHQLTASLAVAEASLRFEHRDLHWGN 213 Query: 196 I 196 + Sbjct: 214 V 214 >6BHC-A nrPDB Length = 438 Score = 51.2 bits (121), Expect = 7e-07, Method: Composition-based stats. Identities = 39/305 (12%), Positives = 87/305 (28%), Gaps = 87/305 (28%) Query: 94 MARKLIHLEIKP--------AIRNQIIRELQVLHECNS-----PYIVGFYGAFYSDG--E 138 A K+ + K A+R + + +C P + + Sbjct: 86 YAVKICKSKAKESQQYYHSLAVRQSLAVHFNIQQDCGHFLAEVPNRLLPWEDPSKKQRSH 145 Query: 139 ISICMEHMDGGSLDQVLK-------KAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDV 191 + + + ++ ++ K+ + E+ + + + + GL +L+ H + H D+ Sbjct: 146 VVVITREVPCLTVADFVRDSLAQHGKSPDLYERQVCLLLLQLCSGLEHLKPYH-VTHCDL 204 Query: 192 KPSNILVNS---------------------RGEIKLCDFGVSGQLIDSMANSFVGTRSYM 230 + N+L+ + + +F + Q + + +S + Sbjct: 205 RLENLLLVHYQPGGTAQGFGPAEPTPTSSYPTRLIVSNFSQAKQKSHLVDPEILRDQSRL 264 Query: 231 SPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRP 290 +PE + T Y + D + G+ + EM P Sbjct: 265 APEIITATQY-KKCDEFQTGILIYEMLHLPNPFD-------------------------- 297 Query: 291 RTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERA 350 P Y P + +S Q + L NP+ER Sbjct: 298 ENPELKEREYTRADLPRIPFRSP----------------YSRGLQQLASCLLNPNPSERI 341 Query: 351 DLKQL 355 + Sbjct: 342 LISDA 346 >6EWX-A nrPDB Length = 484 Score = 51.2 bits (121), Expect = 7e-07, Method: Composition-based stats. Identities = 32/235 (13%), Positives = 67/235 (28%), Gaps = 86/235 (36%) Query: 163 EQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRG-------------------- 202 E+ + + + + GL +L+E H I+HRD+ N+L+ Sbjct: 209 ERRVCFLLLQLCNGLEHLKE-HGIIHRDLCLENLLLVHCNPQSSPGPSANPSVPTTTSRC 267 Query: 203 ---------------------EIKLCDFGVSGQLIDSMAN-SFVGTRSYMSPERLQGTHY 240 + + +F + Q N +++ ++PE + + Y Sbjct: 268 PSAAPAATTACQGGPGEKHLPRLIISNFLKAKQKPGGTTNLQQKKSQARLAPEIVSASQY 327 Query: 241 SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY 300 + D + G+ + E+ P Sbjct: 328 -RKFDEFQTGILIYELLHQPNPF------------------------------------- 349 Query: 301 GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQL 355 A DY + PP ++S Q + L +P +R + + Sbjct: 350 -----EVRAQLRERDYRREDLPPLPTLSLYSPGLQQLAHLLLEADPIKRIRIGEA 399 >3BYV-A nrPDB Length = 377 Score = 49.7 bits (117), Expect = 2e-06, Method: Composition-based stats. Identities = 29/204 (14%), Positives = 68/204 (33%), Gaps = 41/204 (20%) Query: 95 ARKLIHLEIKPAIRNQIIRELQVLHECN-SPYIV------------GFYGAFYSDGEISI 141 A K + E+ +R +++R ++ + + + ++ + Sbjct: 116 AIKQMKEEV---LRLRLLRGIKNQKQAKVHLRFIFPFDLVKDPQKKKMIRVRLDERDMWV 172 Query: 142 CMEH-----MD------GGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRD 190 M G L + ++++ VI+ L L + ++H Sbjct: 173 LSRFFLYPRMQSNLQTFGEVLLSHSSTHKSLVHHARLQLTLQVIRLLASLHH-YGLVHTY 231 Query: 191 VKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPER------LQGTH----- 239 ++P +I+++ RG + L F + D +R + PE + Sbjct: 232 LRPVDIVLDQRGGVFLTGFEH--LVRDGARVVSSVSRGFEPPELEARRATISYHRDRRTL 289 Query: 240 YSVQSDIWSMGLSLVEMAVGRYPI 263 + D W++GL + + PI Sbjct: 290 MTFSFDAWALGLVIYWIWCADLPI 313 >3ENH-A nrPDB Length = 540 Score = 47.8 bits (112), Expect = 8e-06, Method: Composition-based stats. Identities = 26/169 (15%), Positives = 57/169 (33%), Gaps = 27/169 (15%) Query: 46 QRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKP 105 +++++ L K ++K D + + V K + Sbjct: 335 KKRKIPEHLIGKGAEADIKRDSYLDFDVIIK---ERVKKGYR------------DERLDE 379 Query: 106 AIRN-QIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQ 164 IR + RE + L I Y I M +++G V++ Sbjct: 380 NIRKSRTAREARYLALVKDFGIPAPYIFDVDLDNKRIMMSYINGKLAKDVIEDN------ 433 Query: 165 ILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSG 213 ++ + + + L K+ ++H D+ SN + + + + DFG+ Sbjct: 434 --LDIAYKIGEIVGKLH-KNDVIHNDLTTSNFIFDKD--LYIIDFGLGK 477 >4BWP-A nrPDB Length = 448 Score = 47.4 bits (111), Expect = 1e-05, Method: Composition-based stats. Identities = 18/165 (10%), Positives = 50/165 (30%), Gaps = 42/165 (25%) Query: 83 FKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYS----DGE 138 ++ +H +G + IH + + + +++ + +V F + D Sbjct: 67 YRATHNTTGYKYCLRRIHGFRLQSTKCMTL--VEMWKKLQHTNVVQLREVFTTKAFGDNS 124 Query: 139 ISICMEHMDG-----------------------GSLDQVLKKAGR--------IPEQILG 167 + + ++ G G K+ +PE + Sbjct: 125 LVLVYDYHPGSQTLLAKYFTPAPETNGYTDPFQGEARPFSHKSNMQRTSNGPLLPEATIW 184 Query: 168 KVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSR----GEIKLCD 208 + + + GL + + + + P+ I+V + + D Sbjct: 185 SIIMQLTAGLKAIHHA-GLACKVLDPTKIIVTGKRVRFSSCCISD 228 >4CZY-B nrPDB Length = 429 Score = 45.8 bits (107), Expect = 3e-05, Method: Composition-based stats. Identities = 23/140 (16%), Positives = 46/140 (32%), Gaps = 18/140 (12%) Query: 83 FKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYS----DGE 138 +K + +G A + I + I+ + + + IV + AF + D Sbjct: 61 YKAQNNKNGRHFALRRI-EGYRLTNEKAILNVTKEWKKIINANIVTVHEAFTTEFFGDSS 119 Query: 139 ISICMEHMDGGS-LDQV----------LKKAGRIPEQILGKVSIAVIKGLTYLREKHKIM 187 + + L L+ +IPE +L + L + K+ Sbjct: 120 LIFVYDFHPLSETLYDHHFPPNNSHNRLRNTNKIPENLLWSYVCQIANALLAIHNA-KLA 178 Query: 188 HRDVKPSNILVNSRGEIKLC 207 R ++ S I + I+L Sbjct: 179 ARCLELSKI-IWENNRIRLA 197 >4CYJ-A nrPDB Length = 438 Score = 45.8 bits (107), Expect = 3e-05, Method: Composition-based stats. Identities = 28/167 (16%), Positives = 63/167 (37%), Gaps = 27/167 (16%) Query: 82 VFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSD--GEI 139 V+K + +G A + + + I+ ++ + + IV + F + G+ Sbjct: 71 VYKAQNSRNGRHYALRRL-EGYRLTNEKAILNVMKDWKKIKNASIVTIHEVFTTREFGDS 129 Query: 140 SICMEHMDGGSLDQVLKKAGR-------------IPEQILGKVSIAVIKGLTYLREKHKI 186 S+ + D L + L++ +PE + + L + +++ Sbjct: 130 SLIFAY-DFHPLSKTLQEHHFQPIHGNRYRPPPAVPENTIWGYICQIANALKTIHS-NRL 187 Query: 187 MHRDVKPSNILVNSRGEIKLC-----D---FGV-SGQLIDSMANSFV 224 R ++PS I++ I+L D FG+ S +++ FV Sbjct: 188 AARCLEPSKIILTDINRIRLSACAILDVVQFGMNSRSVVELQQEDFV 234 >1TQM-A nrPDB Length = 282 Score = 45.4 bits (106), Expect = 5e-05, Method: Composition-based stats. Identities = 31/165 (18%), Positives = 58/165 (35%), Gaps = 29/165 (17%) Query: 70 KISELGAGNGGVVFKVSHKPSGLVMAR--KLIHLEIKPAIRNQ--------------IIR 113 +G G VF + G + + K+ H K + Sbjct: 94 IGKLMGEGKESAVFNCYSEKFGECVVKFHKVGHTSFKKVKEKRDYGDLHFSVLAIRSARN 153 Query: 114 ELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAV 173 E + L + + Y + + ME +D L +V + P+++L + V Sbjct: 154 EFRALQKLQGLAVPKVYAWEGNA----VLMELIDAKELYRVRVEN---PDEVLDMILEEV 206 Query: 174 IKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS 218 K + I+H D+ N+LV+ G I + DF S ++ + Sbjct: 207 AK---FYH--RGIVHGDLSQYNVLVSEEG-IWIIDFPQSVEVGEE 245 >6M7Z-A nrPDB Length = 319 Score = 44.3 bits (103), Expect = 8e-05, Method: Composition-based stats. Identities = 19/129 (14%), Positives = 49/129 (37%), Gaps = 26/129 (20%) Query: 139 ISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILV 198 ++ + G + +L+ + ++ ++ L L ++HR ++ ++ V Sbjct: 121 LTYIFHPLSKGLVGDMLETGR--SHPDVQVLAANMVAALKSLHNL-GLLHRSIELNSFSV 177 Query: 199 NSRGEIKLCDFGVSGQLIDSMANSFVGTRSYM-------SPER---------LQGTHYSV 242 G + L + + TR ++ +PE L ++V Sbjct: 178 LPDGTVVLGGLDTAAPIGTE-------TRLWVGFFGQETAPEIDRNFLADLALTQGRHTV 230 Query: 243 QSDIWSMGL 251 +SD++S+G+ Sbjct: 231 KSDVYSLGV 239 >5VE6-A nrPDB Length = 492 Score = 43.9 bits (102), Expect = 1e-04, Method: Composition-based stats. Identities = 12/36 (33%), Positives = 23/36 (63%), Gaps = 1/36 (2%) Query: 163 EQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILV 198 E+ + + + + GL +L+E H I+HRD+ N+L+ Sbjct: 207 ERRVCFLLLQLCNGLEHLKE-HGIIHRDLCLENLLL 241 Score = 35.8 bits (81), Expect = 0.033, Method: Composition-based stats. Identities = 17/126 (13%), Positives = 34/126 (26%), Gaps = 43/126 (34%) Query: 230 MSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPR 289 ++PE + + Y + D + G+ + E+ P Sbjct: 325 LAPEIVSASQY-RKFDEFQTGILIYELLHQPNPF-------------------------- 357 Query: 290 PRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAER 349 A DY + PP ++S Q + L +P +R Sbjct: 358 ----------------EVRAQLRERDYRQEDLPPLPALSLYSPGLQQLAHLLLEADPIKR 401 Query: 350 ADLKQL 355 + + Sbjct: 402 IRIGEA 407 >3DZO-A nrPDB Length = 413 Score = 43.5 bits (101), Expect = 2e-04, Method: Composition-based stats. Identities = 31/202 (15%), Positives = 71/202 (35%), Gaps = 40/202 (19%) Query: 95 ARKLIHLEIKPAIRNQIIRELQVLHECN-SPYIV------------GFYGAFYSDGEISI 141 A K + E+ +R +++R ++ + + + ++ + Sbjct: 121 AIKQMKEEV---LRLRLLRGIKNQKQAKVHLRFIFPFDLVKDPQKKKMIRVRLDERDMWV 177 Query: 142 CMEH-----MD------GGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRD 190 M G L + ++++ VI+ L L + ++H Sbjct: 178 LSRFFLYPRMQSNLQTFGEVLLSHSSTHKSLVHHARLQLTLQVIRLLASLHH-YGLVHTY 236 Query: 191 VKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPER----------LQGTHY 240 ++P +I+++ RG + L F + + A S +G R + PE T Sbjct: 237 LRPVDIVLDQRGGVFLTGFEHLVR-DGASAVSPIG-RGFAPPETTAERMLPFGQHHPTLM 294 Query: 241 SVQSDIWSMGLSLVEMAVGRYP 262 + D W++GL++ + P Sbjct: 295 TFAFDTWTLGLAIYWIWCADLP 316 >2W1Z-A nrPDB Length = 368 Score = 43.1 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 53/358 (14%), Positives = 119/358 (33%), Gaps = 76/358 (21%) Query: 23 TSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELKDDD-FEKISELGA----- 76 T + +E L ++ E + + + L +++ F SELG Sbjct: 2 TDPGDVVIEELFNRIPETSVWNENERVLSN-ANHLVSTALWRNEQSFRVESELGERPRTL 60 Query: 77 ---------GNGGVVFKVSHKPSGLVM--------------ARKLIHLEIKPAIRNQIIR 113 G+ + + + + +G + A K + ++ +R +++R Sbjct: 61 VRGPVLRDDGSY-ICLEATDQETGEPLEVHVPYFTERPPSNAIKQLSEQV---LRLRLLR 116 Query: 114 ELQVLHE-------------CNSPYIVGFYGAFYSDGEISIC--------ME---HMDGG 149 ++ + P + ++ + M+ H+ G Sbjct: 117 GIKNQRQAKAYLRFIFPIDLVKDPKKRKMIRVRLDERDMWVLSRFFLYPRMQSNLHILGD 176 Query: 150 SLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDF 209 L + ++++ +I+ L+ + ++H D + NIL++ RG + L F Sbjct: 177 VLLSHSSTHKSLVHHARLQLTLQLIRLAASLQH-YGLVHADFQVRNILLDQRGGVFLTGF 235 Query: 210 GVSGQLIDSMANSFVGTRSYMSPE-----RLQGTHY-----SVQSDIWSMGLSLVEMAVG 259 + + A S +G R + PE L + + D W++GL++ + Sbjct: 236 EHLVR-DGASAVSPIG-RGFAPPETTAERMLPYRQHHPTLMTFPFDTWTLGLAIYWIWCA 293 Query: 260 RYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSR-PPMAIFELLDY 316 P + ++ EL + P R Y + R P+ E +Y Sbjct: 294 DLP----NTEDAELGGIEWIYRRCKNIPQPVRALLEGFLRYSKEDRLLPLQAMETSEY 347 >4WWA-A nrPDB Length = 261 Score = 43.1 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 27/153 (17%), Positives = 49/153 (32%), Gaps = 29/153 (18%) Query: 83 FKVSHKPSGLVMARKLIHLEI-------KPAIRNQIIRELQVLHECN---SPYIVGFYGA 132 + K S K + + +++ + E ++L + + Sbjct: 38 YLPRAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIAC 97 Query: 133 FYSDGEISICM--EHMDGG----SLDQVLKKAGRIPEQ-----ILGKVSIAVIKGLTYLR 181 +G I + E + GG +L L + P L KV + L Sbjct: 98 DPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIG-----LL 152 Query: 182 EKHKIMHRDVKPSNILVNSRG---EIKLCDFGV 211 + H D+ SNI++ G L DFG+ Sbjct: 153 HWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGL 185 >5YK0-A nrPDB Length = 452 Score = 39.7 bits (91), Expect = 0.002, Method: Composition-based stats. Identities = 30/220 (13%), Positives = 71/220 (32%), Gaps = 49/220 (22%) Query: 34 QKKLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISE--LGAGNGGVVFKVSHKPSG 91 ++ L +L+ D + ++G + F ++ + + + G V K G Sbjct: 98 REALTKLQKDAPPLPASKVHRVLDGQLGTKWRERFSSFNDTPVASASIGQVHKAIW-SDG 156 Query: 92 LVMARKLIHLEIKPAIR---NQIIRELQVLHEC--------------------------- 121 +A K+ + A+R + R + VL + Sbjct: 157 REVAVKIQYPGADEALRADLKTMQRMVGVLKQLSPGADVQGVVDELVERTEMELDYRLEA 216 Query: 122 -----------NSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVS 170 + P S ++ + E ++G + ++++ ++G + Sbjct: 217 ANQRAFAKAYHDHPRF-QVPHVVASAPKV-VIQEWIEGVPMAEIIRHGTTEQRDLIGTLL 274 Query: 171 IAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFG 210 + + +MH D P N ++ G + + DFG Sbjct: 275 AELT---FDAPRRLGLMHGDAHPGNFMLLPDGRMGIIDFG 311 >4OTP-A nrPDB Length = 352 Score = 39.7 bits (91), Expect = 0.002, Method: Composition-based stats. Identities = 15/83 (18%), Positives = 36/83 (43%), Gaps = 1/83 (1%) Query: 141 ICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNS 200 + M + + L K ++ E ++ + VI+ + + + +++H D+ N+L + Sbjct: 133 LVMSFIGKDDMPAPLLKNVQLSESKARELYLQVIQYMRRMYQDARLVHADLSEFNMLYHG 192 Query: 201 RGEIKLCDFGVSGQLIDSMANSF 223 G + + D S + A F Sbjct: 193 GG-VYIIDVSQSVEHDHPHALEF 214 >6G5I-z nrPDB Length = 568 Score = 39.7 bits (91), Expect = 0.003, Method: Composition-based stats. Identities = 15/83 (18%), Positives = 36/83 (43%), Gaps = 1/83 (1%) Query: 141 ICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNS 200 + M + + L K ++ E ++ + VI+ + + + +++H D+ N+L + Sbjct: 275 LVMSFIGKDDMPAPLLKNVQLSESKARELYLQVIQYMRRMYQDARLVHADLSEFNMLYHG 334 Query: 201 RGEIKLCDFGVSGQLIDSMANSF 223 G + + D S + A F Sbjct: 335 GG-VYIIDVSQSVEHDHPHALEF 356 >6G18-v nrPDB Length = 552 Score = 38.5 bits (88), Expect = 0.005, Method: Composition-based stats. Identities = 12/78 (15%), Positives = 28/78 (35%), Gaps = 9/78 (11%) Query: 133 FYSDGEISICMEHMDGGSLDQVLKKAGRIPE-QILGKVSIAVIKGLTYLREKHKIMHRDV 191 ++ ME ++G L Q+ ++ + + H ++H D Sbjct: 178 PIDYNRHAVVMELINGYPLCQIHHVEDPASVYDEAMELIVKLAN--------HGLIHGDF 229 Query: 192 KPSNILVNSRGEIKLCDF 209 N++++ I + DF Sbjct: 230 NEFNLILDESDHITMIDF 247 >3Q60-A nrPDB Length = 371 Score = 38.1 bits (87), Expect = 0.007, Method: Composition-based stats. Identities = 38/228 (16%), Positives = 64/228 (28%), Gaps = 55/228 (24%) Query: 150 SLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDF 209 +LD V G L ++ +I+ L+ K ++H P N+ + G + L D Sbjct: 180 TLDFVYVFRGDEGILALHILTAQLIRLAANLQSK-GLVHGHFTPDNLFIMPDGRLMLGD- 237 Query: 210 GVSGQLIDSMANSFVGTRS--------YMSPERLQGT--HYSVQSDIWSMGLSLVEMAVG 259 A VGTR Y E L + ++ + W +GLS+ + Sbjct: 238 --------VSALWKVGTRGPASSVPVTYAPREFLNASTATFTHALNAWQLGLSIYRVWCL 289 Query: 260 RYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVN 319 P V + RP S S P+ F Sbjct: 290 FLPF-------------GLVTPGIKGSWKRPSLRVPGTDSLAFGSCTPLPDF-------- 328 Query: 320 EPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAE 367 + + + L + R + M + E Sbjct: 329 --------------VKTLIGRFLNFDRRRRLLPLEAMETPEFLQLQNE 362 >6FDN-A nrPDB Length = 320 Score = 37.7 bits (86), Expect = 0.008, Method: Composition-based stats. Identities = 12/78 (15%), Positives = 28/78 (35%), Gaps = 9/78 (11%) Query: 133 FYSDGEISICMEHMDGGSLDQVLKKAGRIPE-QILGKVSIAVIKGLTYLREKHKIMHRDV 191 ++ ME ++G L Q+ ++ + + H ++H D Sbjct: 178 PIDYNRHAVVMELINGYPLCQIHHVEDPASVYDEAMELIVKLAN--------HGLIHGDF 229 Query: 192 KPSNILVNSRGEIKLCDF 209 N++++ I + DF Sbjct: 230 NEFNLILDESDHITMIDF 247 >1ZP9-A nrPDB Length = 258 Score = 36.6 bits (83), Expect = 0.018, Method: Composition-based stats. Identities = 16/85 (18%), Positives = 38/85 (44%), Gaps = 4/85 (4%) Query: 141 ICMEHMDGGSLD--QVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILV 198 + ME + L +++ + E + + V++ + L ++ +++H D+ NI+ Sbjct: 145 LLMEFIGEDELPAPTLVELGRELKELDVEGIFNDVVENVKRLYQEAELVHADLSEYNIMY 204 Query: 199 NSRGEIKLCDFGVSGQLIDSMANSF 223 + + D G + L MA S+ Sbjct: 205 IDK--VYFIDMGQAVTLRHPMAESY 227 >2PZ1-A nrPDB Length = 466 Score = 34.3 bits (77), Expect = 0.11, Method: Composition-based stats. Identities = 40/211 (18%), Positives = 66/211 (31%), Gaps = 43/211 (20%) Query: 10 QLNPAPDGSAVNGTSSAETNLEALQKKLEELELD-------------EQQRKRLEAFLTQ 56 Q PA D + + G S AE Q +++ + + R E ++ Q Sbjct: 88 QDEPADDDAPLAGNSGAEDGGAEAQSSKDQMRTNVINEILSTERDYIKHLRDICEGYVRQ 147 Query: 57 KQKVGELKDDDFEKISELGAGNGG------VVFKVSHKPSGLVMARKLIHLEIKPAIRNQ 110 +K ++ + E++ + G K K R+ HL A + Sbjct: 148 CRKRADMFSE--EQLRTI----FGNIEDIYRCQKAFVKALEQRFNRERPHLSELGACFLE 201 Query: 111 IIRELQVLHE--CNSPY-IVGFYGAFYSDGEISICMEHMDG------GSLDQVLKKAGRI 161 + Q+ E N P V + E SLD L Sbjct: 202 HQADFQIYSEYCNNHPNACVELSRLTKLSKYVYF-FEACRLLQKMIDISLDGFL----LT 256 Query: 162 PEQILGKVSIAVIKGLTYLREKHKIMHRDVK 192 P Q + K + + + L Y + HRD K Sbjct: 257 PVQKICKYPLQLAELLKYTHPQ----HRDFK 283 >4BVU-A nrPDB Length = 211 Score = 32.0 bits (71), Expect = 0.51, Method: Composition-based stats. Identities = 32/186 (17%), Positives = 60/186 (32%), Gaps = 30/186 (16%) Query: 70 KISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGF 129 +G G+ +F+ + S L K + E+ + S F Sbjct: 44 LGKLIGQGSTAEIFEDVNDSSALY---------KKYDLIGNQYNEILEMAWQESELFNAF 94 Query: 130 YG-----AFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKH 184 YG G++ + M + G L + IP+ I + K + Sbjct: 95 YGDEASVVIQYGGDVYLRMLRVPGTPLSDI--DTADIPDNIESLYLQLICK-----LNEL 147 Query: 185 KIMHRDVKPSNILVNSRGE-IKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQ 243 I+H D+ N+L + E + DF + A + T+ E + Sbjct: 148 SIIHYDLNTGNMLYDKESESLFPIDF------RNIYAEYYAATKK--DKEIIDRRLQMRT 199 Query: 244 SDIWSM 249 +D +S+ Sbjct: 200 NDFYSL 205 >6DFL-A nrPDB Length = 259 Score = 31.6 bits (70), Expect = 0.55, Method: Composition-based stats. Identities = 24/166 (14%), Positives = 54/166 (32%), Gaps = 17/166 (10%) Query: 75 GAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGF----Y 130 G G + + G + K + P + + +E Q + + + Y Sbjct: 45 GRGYFVKIHRGI--GWGEIA--KNLLTAKLPVLGAR--QEWQAIRRLHEAGVATMTAVAY 98 Query: 131 GAFYSD---GEISICME-HMDGGSLDQVLK--KAGRIPEQILGKVSIAVIKGLTYLREKH 184 G SD I E L+ + + P ++ + AV + + + + Sbjct: 99 GERGSDPARQHSFIVTEELAPTVDLEVFSQDWRERPPPPRLKRALVEAVARMVGDMH-RA 157 Query: 185 KIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYM 230 + HRD + L+++ + DF +S + + + Sbjct: 158 GVNHRDCYICHFLLHTDKPVSADDFRLSVIDLHRAQTRDATPKRWR 203 >6GL3-A nrPDB Length = 386 Score = 30.8 bits (68), Expect = 1.0, Method: Composition-based stats. Identities = 14/62 (22%), Positives = 25/62 (40%), Gaps = 1/62 (1%) Query: 151 LDQVLKKAGRIPEQILGKVSIAVIKGLT-YLREKHKIMHRDVKPSNILVNSRGEIKLCDF 209 LD L++ G + ++ Y + + +D NIL+++ G I DF Sbjct: 219 LDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAEGHIIHIDF 278 Query: 210 GV 211 G Sbjct: 279 GF 280 >4D0L-A nrPDB Length = 566 Score = 30.8 bits (68), Expect = 1.1, Method: Composition-based stats. Identities = 14/62 (22%), Positives = 25/62 (40%), Gaps = 1/62 (1%) Query: 151 LDQVLKKAGRIPEQILGKVSIAVIKGLT-YLREKHKIMHRDVKPSNILVNSRGEIKLCDF 209 LD L++ G + ++ Y + + +D NIL+++ G I DF Sbjct: 398 LDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAEGHIIHIDF 457 Query: 210 GV 211 G Sbjct: 458 GF 459 >5C4G-E nrPDB Length = 529 Score = 30.8 bits (68), Expect = 1.2, Method: Composition-based stats. Identities = 14/62 (22%), Positives = 25/62 (40%), Gaps = 1/62 (1%) Query: 151 LDQVLKKAGRIPEQILGKVSIAVIKGLT-YLREKHKIMHRDVKPSNILVNSRGEIKLCDF 209 LD L++ G + ++ Y + + +D NIL+++ G I DF Sbjct: 361 LDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAEGHIIHIDF 420 Query: 210 GV 211 G Sbjct: 421 GF 422 >2WW2-A nrPDB Length = 737 Score = 30.4 bits (67), Expect = 1.3, Method: Composition-based stats. Identities = 15/88 (17%), Positives = 34/88 (38%), Gaps = 1/88 (1%) Query: 8 PIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELKDDD 67 P +P G + G +S ++A K ++ ++ ++ + + ++ + D Sbjct: 368 PEWASPGHRGCMI-GNNSVSLLVDAWMKGIQTVDAEKALEAMIHQTQARHAEIASVGRDG 426 Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMA 95 FE +LG V + + K A Sbjct: 427 FEYYDKLGYVPYPEVPEATAKTLEYAYA 454 >3W4R-A nrPDB Length = 554 Score = 30.0 bits (66), Expect = 1.8, Method: Composition-based stats. Identities = 13/58 (22%), Positives = 21/58 (36%), Gaps = 3/58 (5%) Query: 2 PKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQK 59 P+ KPT PAP S T E E+ ++ E ++ K++ Sbjct: 457 PEPKPTTSLPTPAPTAST---TEEEAQQPEVELPAENEIGNSDKICTSEEDYIPDKKQ 511 >6EF6-A nrPDB Length = 354 Score = 30.0 bits (66), Expect = 2.0, Method: Composition-based stats. Identities = 9/31 (29%), Positives = 21/31 (67%), Gaps = 3/31 (9%) Query: 182 EKHKIMHRDVKPSNILVNS---RGEIKLCDF 209 +++ ++H D++ +N+LV+S + I + DF Sbjct: 223 DRYGLIHADLRLANLLVDSSTPQRTITVIDF 253 >5M0X-A nrPDB Length = 575 Score = 28.1 bits (61), Expect = 6.7, Method: Composition-based stats. Identities = 19/125 (15%), Positives = 41/125 (32%), Gaps = 8/125 (6%) Query: 272 ELMFGCQVEGDAAETPPRPRTP-GRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVF 330 ++ G ++ G +P R + +++ ++D +PP P+ + Sbjct: 51 KIHLGWKISGRVKGSPGRLEVLRTKAPEKVLVNNWQSWGPCRVVDAFSFKPPEIDPNWRY 110 Query: 331 SLEFQ-DFVNKCLIKN--PAERADLKQLMV----HAFIKRSDAEEVDFAGWLCSTIGLNQ 383 + D + + L + AE + + H F D E V + + Sbjct: 111 TASVVPDVLERNLQSDYFVAEEGKVYGFLSSKIAHPFFAVEDGELVAYLEYFDVEFDDFV 170 Query: 384 PSTPT 388 P P Sbjct: 171 PLEPL 175 >4ZO4-A nrPDB Length = 204 Score = 28.1 bits (61), Expect = 7.3, Method: Composition-based stats. Identities = 17/87 (19%), Positives = 40/87 (45%), Gaps = 12/87 (13%) Query: 95 ARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGF-----YGAFYSDGEISICM---EHM 146 A+K++ P IR +I+ ++Q+L + N + V GA+ + G++ + E Sbjct: 84 AKKILENFTHPKIRAKILEQMQILDKENKAFFVEIPLFFESGAYENLGKVIVIYTPKEL- 142 Query: 147 DGGSLDQVLKKAGRIPEQILGKVSIAV 173 SL +++++ E ++ + Sbjct: 143 ---SLKRIMQRDKLSLEAAKARLDSQI 166 >5U8E-A nrPDB Length = 384 Score = 27.7 bits (60), Expect = 8.7, Method: Composition-based stats. Identities = 11/62 (17%), Positives = 19/62 (30%), Gaps = 3/62 (4%) Query: 146 MDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIK 205 MD + Q++ E + Y I H D K + VN ++ Sbjct: 200 MDKATQQQLIDDHFLFKEGDR---FLQAANACRYWPTGRGIYHNDAKTFLVWVNEEDHLR 256 Query: 206 LC 207 + Sbjct: 257 II 258 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.308 0.134 0.386 Lambda K H 0.267 0.0407 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 15,880,585 Number of Sequences: 36641 Number of extensions: 655323 Number of successful extensions: 6149 Number of sequences better than 10.0: 510 Number of HSP's better than 10.0 without gapping: 870 Number of HSP's successfully gapped in prelim test: 109 Number of HSP's that attempted gapping in prelim test: 2079 Number of HSP's gapped (non-prelim): 1401 length of query: 393 length of database: 10,336,785 effective HSP length: 99 effective length of query: 294 effective length of database: 6,709,326 effective search space: 1972541844 effective search space used: 1972541844 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.1 bits) S2: 60 (27.7 bits)