BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q01813 (784 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 4XYJ-A nrPDB 1623 0.0 3O8N-A nrPDB 1129 0.0 3OPY-A nrPDB 651 0.0 3O8O-B nrPDB 622 e-178 3OPY-B nrPDB 620 e-177 3O8O-A nrPDB 599 e-171 4I4I-A nrPDB 238 9e-63 4A3S-A nrPDB 235 5e-62 5XZ7-A nrPDB 224 9e-59 1ZXX-A nrPDB 204 1e-52 1PFK-A nrPDB 204 1e-52 2HIG-A nrPDB 89 8e-18 3K2Q-A nrPDB 48 1e-05 3HNO-A nrPDB 46 6e-05 1KZH-A nrPDB 45 2e-04 3AHE-A nrPDB 33 0.68 3KNZ-A nrPDB 31 1.6 5J54-A nrPDB 30 3.8 5N5S-A nrPDB 30 4.3 3SLH-A nrPDB 29 9.6 >4XYJ-A nrPDB Length = 812 Score = 1623 bits (4202), Expect = 0.0, Method: Compositional matrix adjust. Identities = 784/784 (100%), Positives = 784/784 (100%) Query: 1 MDADDSRAPKGSLRKFLEHLSGAGKAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFI 60 MDADDSRAPKGSLRKFLEHLSGAGKAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFI Sbjct: 29 MDADDSRAPKGSLRKFLEHLSGAGKAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFI 88 Query: 61 YEGYQGMVDGGSNIAEADWESVSSILQVGGTIIGSARCQAFRTREGRLKAACNLLQRGIT 120 YEGYQGMVDGGSNIAEADWESVSSILQVGGTIIGSARCQAFRTREGRLKAACNLLQRGIT Sbjct: 89 YEGYQGMVDGGSNIAEADWESVSSILQVGGTIIGSARCQAFRTREGRLKAACNLLQRGIT 148 Query: 121 NLCVIGGDGSLTGANLFRKEWSGLLEELARNGQIDKEAVQKYAYLNVVGMVGSIDNDFCG 180 NLCVIGGDGSLTGANLFRKEWSGLLEELARNGQIDKEAVQKYAYLNVVGMVGSIDNDFCG Sbjct: 149 NLCVIGGDGSLTGANLFRKEWSGLLEELARNGQIDKEAVQKYAYLNVVGMVGSIDNDFCG 208 Query: 181 TDMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLP 240 TDMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLP Sbjct: 209 TDMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLP 268 Query: 241 ESPPEEGWEEQMCVKLSENRARKKRLNIIIVAEGAIDTQNKPITSEKIKELVVTQLGYDT 300 ESPPEEGWEEQMCVKLSENRARKKRLNIIIVAEGAIDTQNKPITSEKIKELVVTQLGYDT Sbjct: 269 ESPPEEGWEEQMCVKLSENRARKKRLNIIIVAEGAIDTQNKPITSEKIKELVVTQLGYDT 328 Query: 301 RVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEATPDTPACVVSLNGNHAVRLPLMEC 360 RVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEATPDTPACVVSLNGNHAVRLPLMEC Sbjct: 329 RVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEATPDTPACVVSLNGNHAVRLPLMEC 388 Query: 361 VQMTQDVQKAMDERRFQDAVRLRGRSFAGNLNTYKRLAIKLPDDQIPKTNCNVAVINVGA 420 VQMTQDVQKAMDERRFQDAVRLRGRSFAGNLNTYKRLAIKLPDDQIPKTNCNVAVINVGA Sbjct: 389 VQMTQDVQKAMDERRFQDAVRLRGRSFAGNLNTYKRLAIKLPDDQIPKTNCNVAVINVGA 448 Query: 421 PAAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGTK 480 PAAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGTK Sbjct: 449 PAAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGTK 508 Query: 481 RVLPGKYLEEIATQMRTHSINALLIIGGFEAYLGLLELSAAREKHEEFCVPMVMVPATVS 540 RVLPGKYLEEIATQMRTHSINALLIIGGFEAYLGLLELSAAREKHEEFCVPMVMVPATVS Sbjct: 509 RVLPGKYLEEIATQMRTHSINALLIIGGFEAYLGLLELSAAREKHEEFCVPMVMVPATVS 568 Query: 541 NNVPGSDFSIGADTALNTITDTCDRIKQSASGTKRRVFIIETMGGYCGYLANMGGLAAGA 600 NNVPGSDFSIGADTALNTITDTCDRIKQSASGTKRRVFIIETMGGYCGYLANMGGLAAGA Sbjct: 569 NNVPGSDFSIGADTALNTITDTCDRIKQSASGTKRRVFIIETMGGYCGYLANMGGLAAGA 628 Query: 601 DAAYIFEEPFDIRDLQSNVEHLTEKMKTTIQRGLVLRNESCSENYTTDFIYQLYSEEGKG 660 DAAYIFEEPFDIRDLQSNVEHLTEKMKTTIQRGLVLRNESCSENYTTDFIYQLYSEEGKG Sbjct: 629 DAAYIFEEPFDIRDLQSNVEHLTEKMKTTIQRGLVLRNESCSENYTTDFIYQLYSEEGKG 688 Query: 661 VFDCRKNVLGHMQQGGAPSPFDRNFGTKISARAMEWITAKLKEARGRGKKFTTDDSICVL 720 VFDCRKNVLGHMQQGGAPSPFDRNFGTKISARAMEWITAKLKEARGRGKKFTTDDSICVL Sbjct: 689 VFDCRKNVLGHMQQGGAPSPFDRNFGTKISARAMEWITAKLKEARGRGKKFTTDDSICVL 748 Query: 721 GISKRNVIFQPVAELKKQTDFEHRIPKEQWWLKLRPLMKILAKYKASYDVSDSGQLEHVQ 780 GISKRNVIFQPVAELKKQTDFEHRIPKEQWWLKLRPLMKILAKYKASYDVSDSGQLEHVQ Sbjct: 749 GISKRNVIFQPVAELKKQTDFEHRIPKEQWWLKLRPLMKILAKYKASYDVSDSGQLEHVQ 808 Query: 781 PWSV 784 PWSV Sbjct: 809 PWSV 812 >3O8N-A nrPDB Length = 762 Score = 1129 bits (2921), Expect = 0.0, Method: Compositional matrix adjust. Identities = 544/752 (72%), Positives = 637/752 (84%), Gaps = 4/752 (0%) Query: 22 GAGKAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGGSNIAEADWES 81 G GKAI VLTSGGDAQGMNAAVRAVVR+GI+ GA+V+F++EGYQG+VDGG +I EA WES Sbjct: 13 GVGKAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGGDHIREATWES 72 Query: 82 VSSILQVGGTIIGSARCQAFRTREGRLKAACNLLQRGITNLCVIGGDGSLTGANLFRKEW 141 VS +LQ+GGT+IGSARC+ FR REGRL+AA NL++RGITNLCVIGGDGSLTGA+ FR EW Sbjct: 73 VSMMLQLGGTVIGSARCKDFREREGRLRAAHNLVKRGITNLCVIGGDGSLTGADTFRSEW 132 Query: 142 SGLLEELARNGQIDKEAVQKYAYLNVVGMVGSIDNDFCGTDMTIGTDSALHRIIEVVDAI 201 S LL +L + G+I E + +YLN+VG+VGSIDNDFCGTDMTIGTDSALHRI E+VDAI Sbjct: 133 SDLLSDLQKAGKITAEEATRSSYLNIVGLVGSIDNDFCGTDMTIGTDSALHRITEIVDAI 192 Query: 202 MTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEEGWEEQMCVKLSENRA 261 TTAQSHQRTFVLEVMGRHCGYLALV++L+CGADWVF+PE PP++ WE+ +C +LSE R Sbjct: 193 TTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDDNWEDHLCRRLSETRT 252 Query: 262 RKKRLNIIIVAEGAIDTQNKPITSEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRIL 321 R RLNIIIVAEGAID KPITSE +K+LVV +LGYDTRVT+LGHVQRGGTPSAFDRIL Sbjct: 253 RGSRLNIIIVAEGAIDRNGKPITSEGVKDLVVRRLGYDTRVTVLGHVQRGGTPSAFDRIL 312 Query: 322 ASRMGVEAVIALLEATPDTPACVVSLNGNHAVRLPLMECVQMTQDVQKAMDERRFQDAVR 381 SRMGVEAV+ALLE TPDTPACVVSL+GN AVRLPLMECVQ+T+DV KAMDE+RF +A++ Sbjct: 313 GSRMGVEAVMALLEGTPDTPACVVSLSGNQAVRLPLMECVQVTKDVTKAMDEKRFDEAMK 372 Query: 382 LRGRSFAGNLNTYKRLAIKLPDDQIPKT-NCNVAVINVGAPAAGMNAAVRSAVRVGIADG 440 LRGRSF N YK LA P PK+ + VAV+NVGAPAAGMNAAVRS VR+G+ G Sbjct: 373 LRGRSFMNNWEVYKLLAHIRP--PAPKSGSYTVAVMNVGAPAAGMNAAVRSTVRIGLIQG 430 Query: 441 HRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGTKRVLPGKYLEEIATQMRTHSI 500 +R+L ++DGF+G AKGQI+E GW+ VGGWTGQGGS LG+KR LP K E+I+ + +I Sbjct: 431 NRVLVVHDGFEGPAKGQIEEAGWSYVGGWTGQGGSKLGSKRTLPKKSFEQISANITKFNI 490 Query: 501 NALLIIGGFEAYLGLLELSAAREKHEEFCVPMVMVPATVSNNVPGSDFSIGADTALNTIT 560 L+IIGGFEAY G LEL R++ +E C+P V++PATVSNNVPGSDFS+GADTALNTI Sbjct: 491 QGLVIIGGFEAYTGGLELMEGRKQFDELCIPFVVIPATVSNNVPGSDFSVGADTALNTIC 550 Query: 561 DTCDRIKQSASGTKRRVFIIETMGGYCGYLANMGGLAAGADAAYIFEEPFDIRDLQSNVE 620 TCDRIKQSA+GTKRRVFIIETMGGYCGYLA M GLAAGADAAYIFEEPF IRDLQ+NVE Sbjct: 551 TTCDRIKQSAAGTKRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDLQANVE 610 Query: 621 HLTEKMKTTIQRGLVLRNESCSENYTTDFIYQLYSEEGKGVFDCRKNVLGHMQQGGAPSP 680 HL +KMKTT++RGLVLRNE C+ENYTTDFI+ LYSEEGKG+FD RKNVLGHMQQGG+P+P Sbjct: 611 HLVQKMKTTVKRGLVLRNEKCNENYTTDFIFNLYSEEGKGIFDSRKNVLGHMQQGGSPTP 670 Query: 681 FDRNFGTKISARAMEWITAKLKEARGRGKKF-TTDDSICVLGISKRNVIFQPVAELKKQT 739 FDRNF TK+ A+AM W+ K+KE+ G+ F T DS CVLG+ KR ++FQPV EL+ QT Sbjct: 671 FDRNFATKMGAKAMNWMAGKIKESYRNGRIFANTPDSGCVLGMRKRALVFQPVTELQNQT 730 Query: 740 DFEHRIPKEQWWLKLRPLMKILAKYKASYDVS 771 DFEHRIPKEQWWLKLRP++KILAKY+ D S Sbjct: 731 DFEHRIPKEQWWLKLRPILKILAKYEIDLDTS 762 >3OPY-A nrPDB Length = 989 Score = 651 bits (1680), Expect = 0.0, Method: Compositional matrix adjust. Identities = 348/775 (44%), Positives = 484/775 (62%), Gaps = 41/775 (5%) Query: 25 KAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGGSNIAEADWESVSS 84 K I ++TSGGDA GMNAAVRAV R GI+ G KVY YEGY G+V GG + E W+ V Sbjct: 211 KKIAIITSGGDAPGMNAAVRAVTRAGIFYGCKVYACYEGYTGLVKGGDMLKELQWQDVRG 270 Query: 85 ILQVGGTIIGSARCQAFRTREGRLKAACNLLQRGITNLCVIGGDGSLTGANLFRKEWSGL 144 +L +GGTIIG+ARC+ FR R GRL+A N++ GI L V GGDGSLTGA+LFRKEW L Sbjct: 271 LLSIGGTIIGTARCKEFRERWGRLQACYNMVSNGIDALVVCGGDGSLTGADLFRKEWPEL 330 Query: 145 LEELARNGQIDKEAVQKYAYLNVVGMVGSIDNDFCGTDMTIGTDSALHRIIEVVDAIMTT 204 ++EL +I KE + + L +VG+VGSIDND CGTD TIG S+L RIIE+VD I T Sbjct: 331 IKELLGEDKITKEQYETHRNLTIVGLVGSIDNDMCGTDSTIGAYSSLERIIELVDYIDAT 390 Query: 205 AQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPP-EEGWEEQMCVKLSENRARK 263 A SH R FV+EVMGRHCG+L L+S +A GAD++F+PE PP E W++ + +R + Sbjct: 391 AASHSRAFVVEVMGRHCGWLGLMSGIATGADYIFIPERPPSESNWKDDLKKVCLRHREKG 450 Query: 264 KRLNIIIVAEGAIDTQNKPITSEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILAS 323 +R +IVAEGAID Q PITSE++K+++V ++G DTR+T LGHVQRGG P AFDR LA+ Sbjct: 451 RRKTTVIVAEGAIDDQLNPITSEEVKDVLV-EIGLDTRITRLGHVQRGGAPCAFDRFLAT 509 Query: 324 RMGVEAVIALLEATPDTPACVVSLNGNHAVRLPLMECVQMTQDVQKAMDERRFQDAVRLR 383 GV+AV A+LE+TP P+ V+S+ N VR PL+E V T+ V A++ + F A++LR Sbjct: 510 VQGVDAVRAVLESTPAIPSPVISILENKIVRQPLVESVAQTKTVSAAIEAKDFDKALQLR 569 Query: 384 GRSFAGNLNTYKRLAIKLPDD---QIPKTN-CNVAVINVGAPAAGMNAAVRSAVRVGIAD 439 + FA + + L++ DD +P+++ N+A+I+VGAP + +N A R A +A Sbjct: 570 DQEFATSYENF--LSVSKYDDGSYLVPESSRLNIAIIHVGAPTSALNPATRVATLNSLAK 627 Query: 440 GHRMLAIYDGFDGFAK-GQIKEIGWTDVGGWTGQGGSILGTKRVLPGKYLEEIATQMRTH 498 GHR+ AI +GF G + G ++E+ W DV W GGS +GT R LP + +A + + Sbjct: 628 GHRVFAIRNGFAGLIRHGAVRELNWIDVEDWHNTGGSEIGTNRSLPSDDMGTVAYYFQQY 687 Query: 499 SINALLIIGGFEAYLGLLELSAAREKHEEFCVPMVMVPATVSNNVPGSDFSIGADTALNT 558 + L+IIGGFEA+ L EL AAR ++ F +PM +PATVSNNVPG+++S+G+DT LNT Sbjct: 688 KFDGLIIIGGFEAFTALYELDAARAQYPIFNIPMCCLPATVSNNVPGTEYSLGSDTCLNT 747 Query: 559 ITDTCDRIKQSASGTKRRVFIIETMGGYCGYLANMGGLAAGADAAYIFEEPFDIRDLQSN 618 ++ CD +KQSAS ++RR F++E GGY GYLA+ GL GA A Y E P +++ +Q + Sbjct: 748 LSGYCDAVKQSASASRRRTFVVEVQGGYSGYLASYAGLITGALAVYTPENPINLQTVQED 807 Query: 619 VEHLTEKMKTTIQRG----LVLRNESCSENYTTDFIYQLYSEEGKGVFDCRKNVLGHMQQ 674 +E LT + + + + NE S+ YTTD I + E GKG F+ R V GH+QQ Sbjct: 808 IELLTRTYEEDDGKNRSGKIFIHNEKASKVYTTDLIAAIIGEAGKGRFESRTAVPGHVQQ 867 Query: 675 GGAPSPFDRNFGTKISARAMEWI---------TAKLKEARGRGKKFTTDDSI-------- 717 G +PS DR +++ + +I A L A R +F DD + Sbjct: 868 GKSPSSIDRVNACRLAIKCCNFIEDANFQVKHNANLS-ADERHLRFFYDDGVKTSAVSGK 926 Query: 718 ---------CVLGISKRNVIFQPVAEL-KKQTDFEHRIPKEQWWLKLRPLMKILA 762 V+GI V F PV +L + +T + R K W +L + +L+ Sbjct: 927 SSVIDDNTSVVIGIQGSEVTFTPVKQLWENETHHKWRKGKNVHWEQLNIVSDLLS 981 >3O8O-B nrPDB Length = 766 Score = 622 bits (1604), Expect = e-178, Method: Compositional matrix adjust. Identities = 326/752 (43%), Positives = 478/752 (63%), Gaps = 23/752 (3%) Query: 25 KAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGGSN-IAEADWESVS 83 KAI V+TSGGDA GMN+ VRA+VR I+ G + + + EGY+G+V GG I E WE V Sbjct: 4 KAIAVMTSGGDAPGMNSNVRAIVRSAIFKGCRAFVVMEGYEGLVRGGPEYIKEFHWEDVR 63 Query: 84 SILQVGGTIIGSARCQAFRTREGRLKAACNLLQRGITNLCVIGGDGSLTGANLFRKEWSG 143 GGT IG+ARC F+ REGRL A +L++ G+ L V GGDGSLTGA+LFR EW Sbjct: 64 GWSAEGGTNIGTARCMEFKKREGRLLGAQHLIEAGVDALIVCGGDGSLTGADLFRSEWPS 123 Query: 144 LLEELARNGQIDKEAVQKYAYLNVVGMVGSIDNDFCGTDMTIGTDSALHRIIEVVDAIMT 203 L+EEL + +I E ++ +LN+ G VGSIDND TD TIG SAL RI + +D + Sbjct: 124 LIEELLKTNRISNEQYERMKHLNICGTVGSIDNDMSTTDATIGAYSALDRICKAIDYVEA 183 Query: 204 TAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEEG-WEEQMCVKLSENRAR 262 TA SH R FV+EVMGR+CG+LAL++ +A AD++F+PE P W++QMC +S++R+R Sbjct: 184 TANSHSRAFVVEVMGRNCGWLALLAGIATSADYIFIPEKPATSSEWQDQMCDIVSKHRSR 243 Query: 263 KKRLNIIIVAEGAIDTQNKPITSEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILA 322 KR I++VAEGAI PI+ + +++V +LG DTR+T LGHVQRGGT A+DRILA Sbjct: 244 GKRTTIVVVAEGAIAADLTPISPSDVHKVLVDRLGLDTRITTLGHVQRGGTAVAYDRILA 303 Query: 323 SRMGVEAVIALLEATPDTPACVVSLNGNHAVRLPLMECVQMTQDVQKAMDERRFQDAVRL 382 + G+EAV A+LE+TPDTP+ ++++N N VR PLME V++T+ V +A+ + F+ A+ L Sbjct: 304 TLQGLEAVNAVLESTPDTPSPLIAVNENKIVRKPLMESVKLTKAVAEAIQAKDFKRAMSL 363 Query: 383 RGRSFAGNLNTYKRLAIKLPDDQIPK----TNCNVAVINVGAPAAGMNAAVRSAVRVGIA 438 R F +LN + +AI D PK +A++NVGAPA G+N+AV S ++ Sbjct: 364 RDTEFIEHLNNF--MAINSADHNEPKLPKDKRLKIAIVNVGAPAGGINSAVYSMATYCMS 421 Query: 439 DGHRMLAIYDGFDGFAKGQ-IKEIGWTDVGGWTGQGGSILGTKRVLPGKY-LEEIATQMR 496 GHR AIY+G+ G A+ + ++ + W D+ GW +GGS +GT RV P + L IA + Sbjct: 422 QGHRPYAIYNGWSGLARHESVRSLNWKDMLGWQSRGGSEIGTNRVTPEEADLGMIAYYFQ 481 Query: 497 THSINALLIIGGFEAYLGLLELSAAREKHEEFCVPMVMVPATVSNNVPGSDFSIGADTAL 556 + + L+I+GGFEA+ L +L ARE + F +PMV++PAT+SNNVPG+++S+G+DTAL Sbjct: 482 KYEFDGLIIVGGFEAFESLHQLERARESYPAFRIPMVLIPATLSNNVPGTEYSLGSDTAL 541 Query: 557 NTITDTCDRIKQSASGTKRRVFIIETMGGYCGYLANMGGLAAGADAAYIFEEPFDIRDLQ 616 N + + CD +KQSAS T+ R F+++ GG GYLA LA GA +Y+ EE + L Sbjct: 542 NALMEYCDVVKQSASSTRGRAFVVDCQGGNSGYLATYASLAVGAQVSYVPEEGISLEQLS 601 Query: 617 SNVEHLTEKMKTTIQRG----LVLRNESCSENYTTDFIYQLYSEEGKGVFDCRKNVLGHM 672 ++E+L + + RG L+L++ + S+ + + ++ + E G FD + GH+ Sbjct: 602 EDIEYLAQSFEKAEGRGRFGKLILKSTNASKALSATKLAEVITAEADGRFDAKPAYPGHV 661 Query: 673 QQGGAPSPFDRNFGTKISARAMEWIT---AKLKEARGRGKKFTTD-----DSICVLGISK 724 QQGG PSP DR T+++ +A+ +I A + EAR + F D D+ V+G+ Sbjct: 662 QQGGLPSPIDRTRATRMAIKAVGFIKDNQAAIAEARAAEENFNADDKTISDTAAVVGVKG 721 Query: 725 RNVIFQPVAEL-KKQTDFEHRIPKEQWWLKLR 755 +V++ + +L +T+ R+PK W R Sbjct: 722 SHVVYNSIRQLYDYETEVSMRMPKVIHWQATR 753 >3OPY-B nrPDB Length = 941 Score = 620 bits (1598), Expect = e-177, Method: Compositional matrix adjust. Identities = 328/761 (43%), Positives = 467/761 (61%), Gaps = 19/761 (2%) Query: 20 LSGAGKAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGGSN-IAEAD 78 L+ K IGV+TSGGD+ GMN VRAVVR GIY G KV+ I+EGY+G+V GG I E Sbjct: 177 LNPVRKTIGVMTSGGDSPGMNPFVRAVVRAGIYKGCKVFCIHEGYEGLVRGGEKYIKETQ 236 Query: 79 WESVSSILQVGGTIIGSARCQAFRTREGRLKAACNLLQRGITNLCVIGGDGSLTGANLFR 138 W V L GGT IG+ARC+ FR R GRLKA N++ GI L V GGDGSLTGA+ FR Sbjct: 237 WHDVRGWLVEGGTNIGTARCKEFRERSGRLKACKNMIDMGIDALIVCGGDGSLTGADRFR 296 Query: 139 KEWSGLLEELARNGQIDKEAVQKYAYLNVVGMVGSIDNDFCGTDMTIGTDSALHRIIEVV 198 EW L+EEL + QI ++ + LN+ G VGSIDND TD TIG S+L RI + Sbjct: 297 SEWPSLIEELLQTEQISQQQFNTHQNLNICGAVGSIDNDMSSTDATIGAFSSLDRICRAI 356 Query: 199 DAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESP-PEEGWEEQMCVKLS 257 D I TA SH R F++EVMGRHCG+L L++ LA AD++ +PE P W++QMC + Sbjct: 357 DYIDATANSHSRAFIVEVMGRHCGWLGLLAGLATSADYILIPEKPASSREWQDQMCDIVG 416 Query: 258 ENRARKKRLNIIIVAEGAIDTQNKPITSEKIKELVVTQLGYDTRVTILGHVQRGGTPSAF 317 ++RAR KR I+IVAEGAI PI+ +++K+++V +LG DTRVT LGHVQRGGT AF Sbjct: 417 KHRARGKRKTIVIVAEGAISNDLSPISCDQVKDVLVNRLGLDTRVTTLGHVQRGGTAVAF 476 Query: 318 DRILASRMGVEAVIALLEATPDTPACVVSLNGNHAVRLPLMECVQMTQDVQKAMDERRFQ 377 DRI A+ GVEAV A+LE DTP+ ++++ + R+PL++ V++TQ V K+++ R F+ Sbjct: 477 DRIYATLQGVEAVNAVLECDADTPSPMIAIKEDQITRVPLVDAVELTQQVAKSIESRNFK 536 Query: 378 DAVRLRGRSFAGNLNTY--KRLAIKLPDDQIPKTNCNVAVINVGAPAAGMNAAVRSAVRV 435 A+ LR F ++ + A +P + +A+INVGAPA GMN+AV S Sbjct: 537 KAISLRDSEFVEHMKNFISTNSADHVPPSLPLEKRKKIAIINVGAPAGGMNSAVYSMATY 596 Query: 436 GIADGHRMLAIYDGFDGFAKGQ-IKEIGWTDVGGWTGQGGSILGTKRVLPGKY-LEEIAT 493 ++ GH AI++GF G A+ + ++ I W D+ GW GGS +GT R LP + IA Sbjct: 597 CMSRGHVPYAIHNGFSGLARHESVRSINWLDIEGWGSLGGSEIGTNRTLPNDADIGMIAY 656 Query: 494 QMRTHSINALLIIGGFEAYLGLLELSAAREKHEEFCVPMVMVPATVSNNVPGSDFSIGAD 553 + + L+++GGFEA++ L +L AR + +P+V++PAT+SNNVPG+++S+G+D Sbjct: 657 FFEKYGFDGLILVGGFEAFISLHQLERARINYPSLRIPLVLIPATISNNVPGTEYSLGSD 716 Query: 554 TALNTITDTCDRIKQSASGTKRRVFIIETMGGYCGYLANMGGLAAGADAAYIFEEPFDIR 613 T LN+ + CD IKQSA+ T+ RVF++E GG GY+A LA GA +Y+ EE + Sbjct: 717 TCLNSFMEYCDVIKQSAAATRNRVFVVEVQGGNSGYIATHAQLACGAQISYVPEEGISLA 776 Query: 614 DLQSNVEHLTEKM-----KTTIQRGLVLRNESCSENYTTDFIYQLYSEEGKGVFDCRKNV 668 L+ ++ L E KT R L+L++E+ S+ TT+ I + +E G FD + + Sbjct: 777 QLEMDINSLKESFANDQGKTKSGR-LILKSENASKVLTTEVISTIIDDEASGRFDSKTAI 835 Query: 669 LGHMQQGGAPSPFDRNFGTKISARAMEWITAKLKEAR--GRGKKFTTDDSI----CVLGI 722 GH+QQGG PSP DR ++ + RA+ +I + F D I VLGI Sbjct: 836 PGHVQQGGIPSPMDRVRASRFAIRAVSFIERHSDRCQTFKNSISFRQTDEITSTAVVLGI 895 Query: 723 SKRNVIFQPVAELKK-QTDFEHRIPKEQWWLKLRPLMKILA 762 K + F P+ +L ++D R+ K +W +R + +L+ Sbjct: 896 HKSQLRFTPIRQLYDFESDVPRRMRKNIFWSNVREISDMLS 936 >3O8O-A nrPDB Length = 787 Score = 599 bits (1544), Expect = e-171, Method: Compositional matrix adjust. Identities = 330/768 (42%), Positives = 480/768 (62%), Gaps = 33/768 (4%) Query: 25 KAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGGSNIAEADWESVSS 84 K I V+TSGGD+ GMNAAVRAVVR GI+ G V+ +YEGY+G++ GG + + WE V Sbjct: 6 KKIAVMTSGGDSPGMNAAVRAVVRTGIHFGCDVFAVYEGYEGLLRGGKYLKKMAWEDVRG 65 Query: 85 ILQVGGTIIGSARCQAFRTREGRLKAACNLLQRGITNLCVIGGDGSLTGANLFRKEWSGL 144 L GGT+IG+AR FR REGR +AA NL+ +GI L V GGDGSLTGA+LFR EW L Sbjct: 66 WLSEGGTLIGTARSMEFRKREGRRQAAGNLISQGIDALVVCGGDGSLTGADLFRHEWPSL 125 Query: 145 LEELARNGQIDKEAVQKYAYLNVVGMVGSIDNDFCGTDMTIGTDSALHRIIEVVDAIMTT 204 ++EL G+ KE V Y L++VG+VGSIDND GTD TIG SAL RI E+VD I T Sbjct: 126 VDELVAEGRFTKEEVAPYKNLSIVGLVGSIDNDMSGTDSTIGAYSALERICEMVDYIDAT 185 Query: 205 AQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPE-SPPEEGWEEQMCVKLSENRARK 263 A+SH R FV+EVMGRHCG+LAL++ +A GAD++F+PE + P W++++ +R++ Sbjct: 186 AKSHSRAFVVEVMGRHCGWLALMAGIATGADYIFIPERAVPHGKWQDELKEVCQRHRSKG 245 Query: 264 KRLNIIIVAEGAIDTQNKPITSEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILAS 323 +R N IIVAEGA+D Q P+T+ +K+ ++ +LG DT+VTILGHVQRGGT A DR LA+ Sbjct: 246 RRNNTIIVAEGALDDQLNPVTANDVKDALI-ELGLDTKVTILGHVQRGGTAVAHDRWLAT 304 Query: 324 RMGVEAVIALLEATPDTPACVVSLNGNHAVRLPLMECVQMTQDVQKAMDERRFQDAVRLR 383 GV+AV A+LE TP+TP+ ++ + N +R+PL+E V++T+ V A++ + F A+ LR Sbjct: 305 LQGVDAVKAVLEFTPETPSPLIGILENKIIRMPLVESVKLTKSVATAIENKDFDKAISLR 364 Query: 384 GRSFAGNLNTYKRLAIKLPDD---QIPKTN-CNVAVINVGAPAAGMNAAVRSAVRVGIAD 439 F + L+ + DD +P ++ N+ +++VGAP+A +NAA R+A ++ Sbjct: 365 DTEFIELYENF--LSTTVKDDGSELLPVSDRLNIGIVHVGAPSAALNAATRAATLYCLSH 422 Query: 440 GHRMLAIYDGFDGFAK-GQIKEIGWTDVGGWTGQGGSILGTKRVLPGKYLEEIATQMRTH 498 GH+ AI +GF G + G++KE+ W DV W GGS +GT R + + L IA + + Sbjct: 423 GHKPYAIMNGFSGLIQTGEVKELSWIDVENWHNLGGSEIGTNRSVASEDLGTIAYYFQKN 482 Query: 499 SINALLIIGGFEAYLGLLELSAAREKHEEFCVPMVMVPATVSNNVPGSDFSIGADTALNT 558 ++ L+I+GGFE + L +L R +H F +PM ++PATVSNNVPG+++S+G DT LN Sbjct: 483 KLDGLIILGGFEGFRSLKQLRDGRTQHPIFNIPMCLIPATVSNNVPGTEYSLGVDTCLNA 542 Query: 559 ITDTCDRIKQSASGTKRRVFIIETMGGYCGYLANMGGLAAGADAAYIFEEPFDIRDLQSN 618 + + D IKQSAS T+RRVF+ E GG+ GY+A+ GL GA + Y E+ D+ ++ + Sbjct: 543 LVNYTDDIKQSASATRRRVFVCEVQGGHSGYIASFTGLITGAVSVYTPEKKIDLASIRED 602 Query: 619 VEHLTEKMKTTIQRG----LVLRNESCSENYTTDFIYQLYSEEGKGVFDCRKNVLGHMQQ 674 + L E + L++RNE S Y+T + + SE KG F R + GH+QQ Sbjct: 603 ITLLKENFRHDKGENRNGKLLVRNEQASSVYSTQLLADIISEASKGKFGVRTAIPGHVQQ 662 Query: 675 GGAPSPFDRNFGTKISARAMEWITA--KLKEAR-------------GRGKKFTT----DD 715 GG PS DR ++ + + +++I K EA G+K T DD Sbjct: 663 GGVPSSKDRVTASRFAVKCIKFIEQWNKKNEASPNTDAKVLRFKFDTHGEKVPTVEHEDD 722 Query: 716 SICVLGISKRNVIFQPVAEL-KKQTDFEHRIPKEQWWLKLRPLMKILA 762 S V+ ++ +V F+P+A L + +T+ E R E W + + IL+ Sbjct: 723 SAAVICVNGSHVSFKPIANLWENETNVELRKGFEVHWAEYNKIGDILS 770 >4I4I-A nrPDB Length = 319 Score = 238 bits (606), Expect = 9e-63, Method: Compositional matrix adjust. Identities = 141/312 (45%), Positives = 189/312 (60%), Gaps = 35/312 (11%) Query: 25 KAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGGSNIAEADWESVSS 84 K IGVLTSGGD+ GMNAA+R+VVR IY G +VY +Y GY G++ G NI + + V Sbjct: 2 KRIGVLTSGGDSPGMNAAIRSVVRKAIYHGVEVYGVYHGYAGLIAG--NIKKLEVGDVGD 59 Query: 85 ILQVGGTIIGSARCQAFRTREGRLKAACNLLQRGITNLCVIGGDGSLTGANLFRKEWSGL 144 I+ GGTI+ +ARC F+T EG+ K L + GI L VIGGDGS GA Sbjct: 60 IIHRGGTILYTARCPEFKTEEGQKKGIEQLKKHGIEGLVVIGGDGSYQGA---------- 109 Query: 145 LEELARNGQIDKEAVQKYAYLNVVGMVGSIDNDFCGTDMTIGTDSALHRIIEVVDAIMTT 204 ++L +G VG+ G+IDND GTD TIG D+AL+ +I+ +D I Sbjct: 110 -KKLTEHG------------FPCVGVPGTIDNDIPGTDFTIGFDTALNTVIDAIDKIRDA 156 Query: 205 AQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEEGWEEQMCVKLSENRARKK 264 A SH+RT+V+EVMGRH G +AL S LA GA+ + +PE+ + + +L R K Sbjct: 157 ATSHERTYVIEVMGRHAGDIALWSGLAGGAETILIPEADYD---MNDVIARLKRGHERGK 213 Query: 265 RLNIIIVAEGAIDTQNKPITSEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILASR 324 + +IIIVAEG + +I+E G++TRVT+LGHVQRGG+P+AFDR+LASR Sbjct: 214 KHSIIIVAEGVGSGVD---FGRQIQEAT----GFETRVTVLGHVQRGGSPTAFDRVLASR 266 Query: 325 MGVEAVIALLEA 336 +G AV LLE Sbjct: 267 LGARAVELLLEG 278 Score = 170 bits (430), Expect = 2e-42, Method: Compositional matrix adjust. Identities = 103/288 (35%), Positives = 160/288 (55%), Gaps = 19/288 (6%) Query: 413 VAVINVGAPAAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQ 472 + V+ G + GMNAA+RS VR I G + +Y G+ G G IK++ DVG + Sbjct: 4 IGVLTSGGDSPGMNAAIRSVVRKAIYHGVEVYGVYHGYAGLIAGNIKKLEVGDVGDIIHR 63 Query: 473 GGSILGTKRVLPGKYLE---EIATQMRTHSINALLIIGGFEAYLGLLELSAAREKHEEFC 529 GG+IL T R K E + Q++ H I L++IGG +Y G +L+ E Sbjct: 64 GGTILYTARCPEFKTEEGQKKGIEQLKKHGIEGLVVIGGDGSYQGAKKLT-------EHG 116 Query: 530 VPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRIKQSASGTKRRVFIIETMGGYCGY 589 P V VP T+ N++PG+DF+IG DTALNT+ D D+I+ +A+ + R ++IE MG + G Sbjct: 117 FPCVGVPGTIDNDIPGTDFTIGFDTALNTVIDAIDKIRDAAT-SHERTYVIEVMGRHAGD 175 Query: 590 LANMGGLAAGADAAYIFEEPFDIRDLQSNVEHLTEKMKTTIQRGLVLRNESCSENYTTDF 649 +A GLA GA+ I E +D+ D+ + ++ E+ K + +++ E DF Sbjct: 176 IALWSGLAGGAETILIPEADYDMNDVIARLKRGHERGK---KHSIIIVAEGVGSG--VDF 230 Query: 650 IYQLYSEEGKGVFDCRKNVLGHMQQGGAPSPFDRNFGTKISARAMEWI 697 Q+ G F+ R VLGH+Q+GG+P+ FDR +++ ARA+E + Sbjct: 231 GRQIQEATG---FETRVTVLGHVQRGGSPTAFDRVLASRLGARAVELL 275 >4A3S-A nrPDB Length = 319 Score = 235 bits (600), Expect = 5e-62, Method: Compositional matrix adjust. Identities = 148/347 (42%), Positives = 203/347 (58%), Gaps = 38/347 (10%) Query: 25 KAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGGSNIAEADWESVSS 84 K IGVLTSGGD+ GMNAAVRAVVR IY +VY IY GY G++ G I + + SV Sbjct: 2 KRIGVLTSGGDSPGMNAAVRAVVRKAIYHDVEVYGIYNGYAGLISG--KIEKLELGSVGD 59 Query: 85 ILQVGGTIIGSARCQAFRTREGRLKAACNLLQRGITNLCVIGGDGSLTGANLFRKEWSGL 144 I+ GGT + +ARC F+T EGR K NL + GI L VIGGDGS GA Sbjct: 60 IIHRGGTKLYTARCPEFKTVEGREKGIANLKKLGIEGLVVIGGDGSYMGA---------- 109 Query: 145 LEELARNGQIDKEAVQKYAYLNVVGMVGSIDNDFCGTDMTIGTDSALHRIIEVVDAIMTT 204 ++L +G VG+ G+IDND GTD TIG D+AL+ +I+ +D I T Sbjct: 110 -KKLTEHG------------FPCVGVPGTIDNDIPGTDFTIGFDTALNTVIDAIDKIRDT 156 Query: 205 AQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEEGWEEQMCVKLSENRARKK 264 A SH+RT+V+EVMGRH G +AL + LA GA+ + +PE+ + ++ +L R K Sbjct: 157 ATSHERTYVIEVMGRHAGDIALWAGLAGGAESILIPEADYD---MHEIIARLKRGHERGK 213 Query: 265 RLNIIIVAEGAIDTQNKPITSEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILASR 324 + +IIIVAEG + ++I+E + +TRV++LGH+QRGG+PSA DR+LASR Sbjct: 214 KHSIIIVAEG---VGSGVEFGKRIEE----ETNLETRVSVLGHIQRGGSPSAADRVLASR 266 Query: 325 MGVEAVIALLEATPDTPACVVSLNGNHAVRLPLMECVQMTQDVQKAM 371 +G AV LLE C V + N V ++E ++ V++ M Sbjct: 267 LGAYAVELLLEGKGGR--C-VGIQNNKLVDHDIIEILETKHTVEQNM 310 Score = 149 bits (375), Expect = 6e-36, Method: Compositional matrix adjust. Identities = 103/335 (30%), Positives = 176/335 (52%), Gaps = 31/335 (9%) Query: 413 VAVINVGAPAAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQ 472 + V+ G + GMNAAVR+ VR I + IY+G+ G G+I+++ VG + Sbjct: 4 IGVLTSGGDSPGMNAAVRAVVRKAIYHDVEVYGIYNGYAGLISGKIEKLELGSVGDIIHR 63 Query: 473 GGSILGTKRVLPGKYLE---EIATQMRTHSINALLIIGGFEAYLGLLELSAAREKHEEFC 529 GG+ L T R K +E + ++ I L++IGG +Y+G +L+ E Sbjct: 64 GGTKLYTARCPEFKTVEGREKGIANLKKLGIEGLVVIGGDGSYMGAKKLT-------EHG 116 Query: 530 VPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRIKQSASGTKRRVFIIETMGGYCGY 589 P V VP T+ N++PG+DF+IG DTALNT+ D D+I+ +A+ + R ++IE MG + G Sbjct: 117 FPCVGVPGTIDNDIPGTDFTIGFDTALNTVIDAIDKIRDTAT-SHERTYVIEVMGRHAGD 175 Query: 590 LANMGGLAAGADAAYIFEEPFDIRDLQSNVEHLTEKMKTTIQRGLVLRNESCSENYTTDF 649 +A GLA GA++ I E +D+ ++ + ++ E+ K + +++ E +F Sbjct: 176 IALWAGLAGGAESILIPEADYDMHEIIARLKRGHERGK---KHSIIIVAEGVGSG--VEF 230 Query: 650 IYQLYSEEGKGVFDCRKNVLGHMQQGGAPSPFDRNFGTKISARAMEWITAKLKEARG--- 706 ++ E + R +VLGH+Q+GG+PS DR +++ A A+E L E +G Sbjct: 231 GKRIEEETN---LETRVSVLGHIQRGGSPSAADRVLASRLGAYAVEL----LLEGKGGRC 283 Query: 707 ---RGKKFTTDDSICVLGISKRNVIFQPVAELKKQ 738 + K D I +L ++ + Q + +L K+ Sbjct: 284 VGIQNNKLVDHDIIEIL--ETKHTVEQNMYQLSKE 316 >5XZ7-A nrPDB Length = 330 Score = 224 bits (572), Expect = 9e-59, Method: Compositional matrix adjust. Identities = 134/311 (43%), Positives = 188/311 (60%), Gaps = 33/311 (10%) Query: 25 KAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGGSNIAEADWESVSS 84 K I VLTSGGD+ GMNAAVRAVVR IY +VY +Y GYQG+++ +I + + SV Sbjct: 2 KKIAVLTSGGDSPGMNAAVRAVVRTAIYNEIEVYGVYHGYQGLLN--DDIHKLELGSVGD 59 Query: 85 ILQVGGTIIGSARCQAFRTREGRLKAACNLLQRGITNLCVIGGDGSLTGANLFRKEWSGL 144 +Q GGT + SARC F+ +E R A NL +RGI L VIGGDGS GA +E Sbjct: 60 TIQRGGTFLYSARCPEFKEQEVRKVAIENLRKRGIEGLVVIGGDGSYRGAQRISEEC--- 116 Query: 145 LEELARNGQIDKEAVQKYAYLNVVGMVGSIDNDFCGTDMTIGTDSALHRIIEVVDAIMTT 204 KE + +G+ G+IDND GTD TIG D+AL+ II +VD I T Sbjct: 117 -----------KE-------IQTIGIPGTIDNDINGTDFTIGFDTALNTIIGLVDKIRDT 158 Query: 205 AQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEEGWEEQMCVKLSENRARKK 264 A SH RTF++E MGR CG LAL + L+ GA+ + +PE + +++ K+ + R K Sbjct: 159 ASSHARTFIIEAMGRDCGDLALWAGLSVGAETIVVPEVKTD---IKEIADKIEQGIKRGK 215 Query: 265 RLNIIIVAEGAIDTQNKPITSEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILASR 324 + +I++VAEG +T++ ++ + + D RV++LGHVQRGG+P+ DR+LASR Sbjct: 216 KHSIVLVAEGC-------MTAQDCQKELSQYINVDNRVSVLGHVQRGGSPTGADRVLASR 268 Query: 325 MGVEAVIALLE 335 +G AV L++ Sbjct: 269 LGGYAVDLLMQ 279 Score = 138 bits (347), Expect = 1e-32, Method: Compositional matrix adjust. Identities = 98/301 (32%), Positives = 155/301 (51%), Gaps = 18/301 (5%) Query: 413 VAVINVGAPAAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQ 472 +AV+ G + GMNAAVR+ VR I + + +Y G+ G I ++ VG + Sbjct: 4 IAVLTSGGDSPGMNAAVRAVVRTAIYNEIEVYGVYHGYQGLLNDDIHKLELGSVGDTIQR 63 Query: 473 GGSILGTKRVLPGKYLE--EIATQ-MRTHSINALLIIGGFEAYLGLLELSAAREKHEEFC 529 GG+ L + R K E ++A + +R I L++IGG +Y G A R E Sbjct: 64 GGTFLYSARCPEFKEQEVRKVAIENLRKRGIEGLVVIGGDGSYRG-----AQRISEECKE 118 Query: 530 VPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRIKQSASGTKRRVFIIETMGGYCGY 589 + + +P T+ N++ G+DF+IG DTALNTI D+I+ +AS + R FIIE MG CG Sbjct: 119 IQTIGIPGTIDNDINGTDFTIGFDTALNTIIGLVDKIRDTAS-SHARTFIIEAMGRDCGD 177 Query: 590 LANMGGLAAGADAAYIFEEPFDIRDLQSNVEHLTEKMKTTIQRGLVLRNESCSENYTTDF 649 LA GL+ GA+ + E DI+++ +E ++ K + +VL E C Sbjct: 178 LALWAGLSVGAETIVVPEVKTDIKEIADKIEQGIKRGK---KHSIVLVAEGCMTAQDCQK 234 Query: 650 IYQLYSEEGKGVFDCRKNVLGHMQQGGAPSPFDRNFGTKISARAMEWITAKLKEARGRGK 709 Y D R +VLGH+Q+GG+P+ DR +++ A++ + + + A+G G Sbjct: 235 ELSQYIN-----VDNRVSVLGHVQRGGSPTGADRVLASRLGGYAVDLLM-QGETAKGVGI 288 Query: 710 K 710 K Sbjct: 289 K 289 >1ZXX-A nrPDB Length = 319 Score = 204 bits (519), Expect = 1e-52, Method: Compositional matrix adjust. Identities = 124/311 (39%), Positives = 177/311 (56%), Gaps = 35/311 (11%) Query: 25 KAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGGSNIAEADWESVSS 84 K IG+LTSGGDA GMNAAVRAV R+ I G +V+ I G+ G+V G +I + E V+ Sbjct: 2 KRIGILTSGGDAPGMNAAVRAVTRVAIANGLEVFGIRYGFAGLVAG--DIFPLESEDVAH 59 Query: 85 ILQVGGTIIGSARCQAFRTREGRLKAACNLLQRGITNLCVIGGDGSLTGANLFRKEWSGL 144 ++ V GT + SAR F EG+L L + GI + VIGGDGS GA Sbjct: 60 LINVSGTFLYSARYPEFAEEEGQLAGIEQLKKHGIDAVVVIGGDGSYHGA---------- 109 Query: 145 LEELARNGQIDKEAVQKYAYLNVVGMVGSIDNDFCGTDMTIGTDSALHRIIEVVDAIMTT 204 +L R+G N +G+ G+IDND TD TIG D+A ++ +D I T Sbjct: 110 -LQLTRHG------------FNSIGLPGTIDNDIPYTDATIGYDTACMTAMDAIDKIRDT 156 Query: 205 AQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEEGWEEQMCVKLSENRARKK 264 A SH R F++ VMGR+CG +A+ +ACGAD + +PE P + E++ +L + + K Sbjct: 157 ASSHHRVFIVNVMGRNCGDIAMRVGVACGADAIVIPERPYD---VEEIANRLKQAQESGK 213 Query: 265 RLNIIIVAEGAIDTQNKPITSEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILASR 324 +++VAEG +T+++ + +D R +LGH+QRGGTP+ DR+LAS+ Sbjct: 214 DHGLVVVAEGV-------MTADQFMAELKKYGDFDVRANVLGHMQRGGTPTVSDRVLASK 266 Query: 325 MGVEAVIALLE 335 +G EAV LLE Sbjct: 267 LGSEAVHLLLE 277 Score = 151 bits (381), Expect = 1e-36, Method: Compositional matrix adjust. Identities = 104/291 (35%), Positives = 155/291 (53%), Gaps = 25/291 (8%) Query: 413 VAVINVGAPAAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQ 472 + ++ G A GMNAAVR+ RV IA+G + I GF G G I + DV Sbjct: 4 IGILTSGGDAPGMNAAVRAVTRVAIANGLEVFGIRYGFAGLVAGDIFPLESEDVAHLINV 63 Query: 473 GGSILGTKRVLPGKYLEEIAT-----QMRTHSINALLIIGGFEAYLGLLELSAAREKHEE 527 G+ L + R P ++ EE Q++ H I+A+++IGG +Y G L+L+ +H Sbjct: 64 SGTFLYSAR-YP-EFAEEEGQLAGIEQLKKHGIDAVVVIGGDGSYHGALQLT----RH-- 115 Query: 528 FCVPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRIKQSASGTKRRVFIIETMGGYC 587 + +P T+ N++P +D +IG DTA T D D+I+ +AS + RVFI+ MG C Sbjct: 116 -GFNSIGLPGTIDNDIPYTDATIGYDTACMTAMDAIDKIRDTAS-SHHRVFIVNVMGRNC 173 Query: 588 GYLANMGGLAAGADAAYIFEEPFDIRDLQSNVEHLTEKMKTTIQRGLVLRNESCSENYTT 647 G +A G+A GADA I E P+D+ ++ + ++ E K GLV+ E T Sbjct: 174 GDIAMRVGVACGADAIVIPERPYDVEEIANRLKQAQESGK---DHGLVVVAEGV---MTA 227 Query: 648 DFIYQLYSEEGK-GVFDCRKNVLGHMQQGGAPSPFDRNFGTKISARAMEWI 697 D Q +E K G FD R NVLGHMQ+GG P+ DR +K+ + A+ + Sbjct: 228 D---QFMAELKKYGDFDVRANVLGHMQRGGTPTVSDRVLASKLGSEAVHLL 275 >1PFK-A nrPDB Length = 320 Score = 204 bits (518), Expect = 1e-52, Method: Compositional matrix adjust. Identities = 127/310 (40%), Positives = 174/310 (56%), Gaps = 35/310 (11%) Query: 25 KAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGGSNIAEADWESVSS 84 K IGVLTSGGDA GMNAA+R VVR + G +V IY+GY G+ + + + D SVS Sbjct: 3 KKIGVLTSGGDAPGMNAAIRGVVRSALTEGLEVMGIYDGYLGLYE--DRMVQLDRYSVSD 60 Query: 85 ILQVGGTIIGSARCQAFRTREGRLKAACNLLQRGITNLCVIGGDGSLTGANLFRKEWSGL 144 ++ GGT +GSAR FR R A NL +RGI L VIGGDGS GA Sbjct: 61 MINRGGTFLGSARFPEFRDENIRAVAIENLKKRGIDALVVIGGDGSYMGAMR-------- 112 Query: 145 LEELARNGQIDKEAVQKYAYLNVVGMVGSIDNDFCGTDMTIGTDSALHRIIEVVDAIMTT 204 L E+ +G+ G+IDND GTD TIG +AL ++E +D + T Sbjct: 113 LTEMG---------------FPCIGLPGTIDNDIKGTDYTIGFFTALSTVVEAIDRLRDT 157 Query: 205 AQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEEGWEEQMCVKLSENRARKK 264 + SHQR V+EVMGR+CG L L +A+A G ++V +PE E E + ++ A+ K Sbjct: 158 SSSHQRISVVEVMGRYCGDLTLAAAIAGGCEFVVVPEV---EFSREDLVNEIKAGIAKGK 214 Query: 265 RLNIIIVAEGAIDTQNKPITSEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILASR 324 + I+ + E D +++ + + G +TR T+LGH+QRGG+P +DRILASR Sbjct: 215 KHAIVAITEHMCDV-------DELAHFIEKETGRETRATVLGHIQRGGSPVPYDRILASR 267 Query: 325 MGVEAVIALL 334 MG A+ LL Sbjct: 268 MGAYAIDLLL 277 Score = 142 bits (359), Expect = 4e-34, Method: Compositional matrix adjust. Identities = 85/291 (29%), Positives = 156/291 (53%), Gaps = 19/291 (6%) Query: 412 NVAVINVGAPAAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWTG 471 + V+ G A GMNAA+R VR + +G ++ IYDG+ G + ++ ++ V Sbjct: 4 KIGVLTSGGDAPGMNAAIRGVVRSALTEGLEVMGIYDGYLGLYEDRMVQLDRYSVSDMIN 63 Query: 472 QGGSILGTKRV--LPGKYLEEIATQ-MRTHSINALLIIGGFEAYLGLLELSAAREKHEEF 528 +GG+ LG+ R + + +A + ++ I+AL++IGG +Y+G + L+ E Sbjct: 64 RGGTFLGSARFPEFRDENIRAVAIENLKKRGIDALVVIGGDGSYMGAMRLT-------EM 116 Query: 529 CVPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRIKQSASGTKRRVFIIETMGGYCG 588 P + +P T+ N++ G+D++IG TAL+T+ + DR++ ++S + +R+ ++E MG YCG Sbjct: 117 GFPCIGLPGTIDNDIKGTDYTIGFFTALSTVVEAIDRLRDTSS-SHQRISVVEVMGRYCG 175 Query: 589 YLANMGGLAAGADAAYIFEEPFDIRDLQSNVEHLTEKMKTTIQRGLVLRNESCSENYTTD 648 L +A G + + E F DL + ++ K K + + C + Sbjct: 176 DLTLAAAIAGGCEFVVVPEVEFSREDLVNEIKAGIAKGKK--HAIVAITEHMCDVDELAH 233 Query: 649 FIYQLYSEEGKGVFDCRKNVLGHMQQGGAPSPFDRNFGTKISARAMEWITA 699 FI + E G+ + R VLGH+Q+GG+P P+DR +++ A A++ + A Sbjct: 234 FIEK---ETGR---ETRATVLGHIQRGGSPVPYDRILASRMGAYAIDLLLA 278 >2HIG-A nrPDB Length = 487 Score = 88.6 bits (218), Expect = 8e-18, Method: Compositional matrix adjust. Identities = 101/383 (26%), Positives = 171/383 (44%), Gaps = 61/383 (15%) Query: 19 HLSGAGKAIGVLTSGGDAQGMNAAVRAVVRMGI--YVGAKVYFIYEGYQGMVDGGSNIA- 75 H + IG++T GG G+N +R++ GI Y +V GY G+ GS A Sbjct: 92 HFNPTETTIGIVTCGGICPGLNDVIRSITLTGINVYNVKRVIGFRFGYWGLSKKGSQTAI 151 Query: 76 EADWESVSSILQVGGTIIGSARCQAFRTREGRLKAACNLLQR-GITNLCVIGGDGSLTGA 134 E V++I GGTI+GS+R K + L+R G+ L +GGDG+ GA Sbjct: 152 ELHRGRVTNIHHYGGTILGSSRGPQ------DPKEMVDTLERLGVNILFTVGGDGTQRGA 205 Query: 135 NLFRKEWSGLLEELARNGQIDKEAVQKYAYLNVVGMVGSIDNDFCGTDMTIGTDSALHRI 194 + I +EA ++ ++V G+ +IDND + T G +A+ + Sbjct: 206 LV-----------------ISQEAKRRGVDISVFGVPKTIDNDLSFSHRTFGFQTAVEKA 248 Query: 195 IEVVDAIMTTAQSHQRTF-VLEVMGRHCGYL-ALVSALACGADWVFLPESPPEEGWEEQM 252 ++ + A A S V+++MGR G++ A + + A+ +PE+P EQ Sbjct: 249 VQAIRAAYAEAVSANYGVGVVKLMGRDSGFIAAQAAVASAQANICLVPENP----ISEQE 304 Query: 253 CVKLSENRARKKRLNIIIVAE----------GAIDTQ-NKP------ITSEKIKELVVTQ 295 + L E R R +IIVAE G D NK I +EK+K + Sbjct: 305 VMSLLERRFCHSRSCVIIVAEGFGQDWGRGSGGYDASGNKKLIDIGVILTEKVKAFLKAN 364 Query: 296 LGY--DTRVTIL--GHVQRGGTPSAFDRILASRMGVEAVIALLEATPDTPACVVSLNGNH 351 D+ V + ++ R PSA D + + + A +A+ EA C++++ N+ Sbjct: 365 KSRYPDSTVKYIDPSYMIRACPPSANDALFCATL---ATLAVHEAMAGATGCIIAMRHNN 421 Query: 352 AVRLPLMECVQMTQDVQKAMDER 374 + +P +++ V++ +D R Sbjct: 422 YILVP----IKVATSVRRVLDLR 440 Score = 37.7 bits (86), Expect = 0.018, Method: Compositional matrix adjust. Identities = 45/187 (24%), Positives = 75/187 (40%), Gaps = 8/187 (4%) Query: 409 TNCNVAVINVGAPAAGMNAAVRSAVRVGIA--DGHRMLAIYDGFDGFAKGQIK---EIGW 463 T + ++ G G+N +RS GI + R++ G+ G +K + E+ Sbjct: 96 TETTIGIVTCGGICPGLNDVIRSITLTGINVYNVKRVIGFRFGYWGLSKKGSQTAIELHR 155 Query: 464 TDVGGWTGQGGSILGTKRVLPGKYLEEIATQMRTHSINALLIIGGFEAYLGLLELSAARE 523 V GG+ILG+ R P E + T R +N L +GG G L +S Sbjct: 156 GRVTNIHHYGGTILGSSRG-PQDPKEMVDTLERL-GVNILFTVGGDGTQRGALVIS-QEA 212 Query: 524 KHEEFCVPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRIKQSASGTKRRVFIIETM 583 K + + VP T+ N++ S + G TA+ A V +++ M Sbjct: 213 KRRGVDISVFGVPKTIDNDLSFSHRTFGFQTAVEKAVQAIRAAYAEAVSANYGVGVVKLM 272 Query: 584 GGYCGYL 590 G G++ Sbjct: 273 GRDSGFI 279 >3K2Q-A nrPDB Length = 420 Score = 48.1 bits (113), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 58/235 (24%), Positives = 96/235 (40%), Gaps = 27/235 (11%) Query: 489 EEIATQMRTHSINALLIIGGFEAYLGLLELSAAREKHEEFCVPMVMVPATVSNNVPGSDF 548 E + R H I GG ++ ++S ++ + + + VP TV N++P +D Sbjct: 94 ERLIEVFRAHDIGYFFYNGGGDSQDTAYKVSQLADRMG-YPITCIGVPKTVDNDLPFTDC 152 Query: 549 -----SIGADTALNTITDTCDRIKQSASGTKRRVFIIETMGGYCGYLANMGGLAAGADAA 603 S+ A +T+ + D +S T +VFI+E MG + G++A GGLA ++ Sbjct: 153 CPGFGSVAKYIATSTLEASLD--IKSMCETSTKVFILEVMGRHAGWIAAAGGLAGQSEG- 209 Query: 604 YIFEEPFDI--RDLQSNVEHLTEKMKTTIQ-RGLVLRNESCSENYTTDFIYQLYSEEGKG 660 E P I ++ N E E++ ++ G + S Y E+G+ Sbjct: 210 ---EPPHVILFPEIPFNREKFLERVDQCVRDYGYCVVVASEGAQY----------EDGRF 256 Query: 661 VFDC-RKNVLGHMQQGGAPSPFDRNFGTKISARAMEWITAKLKEARGRGKKFTTD 714 V D K+ GH Q GG +P N + W A + R TD Sbjct: 257 VADAGAKDAFGHTQLGGV-APALANMVKQALGHKYHWAVADYLQRAARHIASATD 310 Score = 46.6 bits (109), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 38/171 (22%), Positives = 69/171 (40%), Gaps = 26/171 (15%) Query: 165 LNVVGMVGSIDNDFCGTDMTIGTDSALHRI----IEVVDAIMTTAQSHQRTFVLEVMGRH 220 + +G+ ++DND TD G S I +E I + ++ + F+LEVMGRH Sbjct: 134 ITCIGVPKTVDNDLPFTDCCPGFGSVAKYIATSTLEASLDIKSMCETSTKVFILEVMGRH 193 Query: 221 CGYLALVSALACGADW-----VFLPESPPEEGWEEQMCVKLSENRARKKRLNIIIVAEGA 275 G++A LA ++ + PE P + + ++ + R +++ +EGA Sbjct: 194 AGWIAAAGGLAGQSEGEPPHVILFPEIP----FNREKFLERVDQCVRDYGYCVVVASEGA 249 Query: 276 IDTQNKPITSEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILASRMG 326 + + K+ GH Q GG A ++ +G Sbjct: 250 QYEDGRFVADAGAKD-------------AFGHTQLGGVAPALANMVKQALG 287 >3HNO-A nrPDB Length = 419 Score = 46.2 bits (108), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 39/148 (26%), Positives = 69/148 (46%), Gaps = 13/148 (8%) Query: 489 EEIATQMRTHSINALLIIGGFEAYLGLLELSAAREKHEEFCVPMVMVPATVSNNVPGSDF 548 E + + H I GG ++ L++S + + + VP TV N++P +D Sbjct: 94 ERLIEVFKAHDIGYFFYNGGGDSADTCLKVSQLSGTLG-YPIQAIHVPKTVDNDLPITDC 152 Query: 549 -----SIGADTALNTITDTCDRIKQSASGTKRRVFIIETMGGYCGYLANMGGLAAGAD-- 601 S+ A++T+ + D SA+ TK VF++E MG + G++A GGLA+ + Sbjct: 153 CPGFGSVAKYIAVSTLEASFDVASMSATSTK--VFVLEVMGRHAGWIAAAGGLASSPERE 210 Query: 602 --AAYIFEE-PFDIRDLQSNVEHLTEKM 626 +F E FD + + V+ +K Sbjct: 211 IPVVILFPEISFDKQKFLAKVDSCVKKF 238 Score = 44.7 bits (104), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 38/165 (23%), Positives = 70/165 (42%), Gaps = 26/165 (15%) Query: 173 SIDNDFCGTDMTIGTDSALHRI----IEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVS 228 ++DND TD G S I +E + + + + + FVLEVMGRH G++A Sbjct: 142 TVDNDLPITDCCPGFGSVAKYIAVSTLEASFDVASMSATSTKVFVLEVMGRHAGWIAAAG 201 Query: 229 ALACGADWVFLPESP-----PEEGWEEQMCVKLSENRARKKRLNIIIVAEGAIDTQNKPI 283 LA + E P PE +++Q + ++ +K ++V+EG K + Sbjct: 202 GLASSPER----EIPVVILFPEISFDKQKFLAKVDSCVKKFGYCSVVVSEGVKGDDGKFL 257 Query: 284 TSEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILASRMGVE 328 + + +++ GH Q GG ++ +G++ Sbjct: 258 SDQGVRDA-------------FGHAQLGGVAPVVASMVKEGLGLK 289 >1KZH-A nrPDB Length = 555 Score = 44.7 bits (104), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 61/249 (24%), Positives = 103/249 (41%), Gaps = 40/249 (16%) Query: 27 IGVLTSGGDAQGMNAAVRAVVRM--GIYVGAKVYFIYEGYQGMVDGGSNIAEADWESVSS 84 IG++ SGG A G + + V +K++ G G+++ E ++S Sbjct: 75 IGIILSGGPAPGGHNVISGVFDAIKKFNPNSKLFGFKGGPLGLLENDK--IELTESLINS 132 Query: 85 ILQVGGTIIGSARCQAFRTREGRLKAACNLLQRGITNLCVIGGDGSLTGANLFRKEWSGL 144 GG I S+ T E KA + + + +IGGD S T A + L Sbjct: 133 YRNTGGFDIVSSGRTKIETEEHYNKALFVAKENNLNAIIIIGGDDSNTNAAI-------L 185 Query: 145 LEELARNGQIDKEAVQKYAYLNVVGMVGSIDNDFCG--TDMTIGTDSALHRIIEVVDAIM 202 E +NG E +Q V+G+ +ID D +++ G DSA E++ + Sbjct: 186 AEYFKKNG----ENIQ------VIGVPKTIDADLRNDHIEISFGFDSATKIYSELIGNLC 235 Query: 203 TTAQSHQRTF-VLEVMGRHCGYLALVSALACGADWVFLPESPPEEGWEEQMCVKLSENRA 261 A S ++ + +++MGR ++AL AL + +C+ E A Sbjct: 236 RDAMSTKKYWHFVKLMGRSASHVALECALKTHPN----------------ICIVSEEVLA 279 Query: 262 RKKRLNIII 270 +KK L+ II Sbjct: 280 KKKTLSEII 288 Score = 32.0 bits (71), Expect = 1.0, Method: Compositional matrix adjust. Identities = 44/235 (18%), Positives = 97/235 (41%), Gaps = 20/235 (8%) Query: 412 NVAVINVGAPAAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQIK-------EIGWT 464 N+ +I G PA G + + G+ D + GF G + E+ + Sbjct: 74 NIGIILSGGPAPGGHNVIS-----GVFDAIKKFNPNSKLFGFKGGPLGLLENDKIELTES 128 Query: 465 DVGGWTGQGGSIL---GTKRVLPGKYLEEIATQMRTHSINALLIIGGFEAYLGLLELSAA 521 + + GG + G ++ ++ + + +++NA++IIGG ++ L+ Sbjct: 129 LINSYRNTGGFDIVSSGRTKIETEEHYNKALFVAKENNLNAIIIIGGDDSNTNAAILAEY 188 Query: 522 REKHEEFCVPMVMVPATVSNNVPGS--DFSIGADTALNTITDTCDRIKQSASGTKRRVFI 579 +K+ E + ++ VP T+ ++ + S G D+A ++ + + A TK+ Sbjct: 189 FKKNGE-NIQVIGVPKTIDADLRNDHIEISFGFDSATKIYSELIGNLCRDAMSTKKYWHF 247 Query: 580 IETMGGYCGYLANMGGLAAGADAAYIFEEPFDIRDLQSNVEHLTEKMKTTIQRGL 634 ++ MG ++A L + + EE + S + + E + ++R L Sbjct: 248 VKLMGRSASHVALECALKTHPNICIVSEEVLAKKKTLSEI--IDEMVSVILKRSL 300 >3AHE-A nrPDB Length = 845 Score = 32.7 bits (73), Expect = 0.68, Method: Compositional matrix adjust. Identities = 19/67 (28%), Positives = 34/67 (50%), Gaps = 9/67 (13%) Query: 625 KMKTTIQRGLVLRNESCSENYTTD----FIYQLYSEEGKGVFDCRKN-----VLGHMQQG 675 K+++ L +E +E +T D F Y Y+++ +G+ R N V+G+ +QG Sbjct: 699 KLQSRENNDEALTDEEFTELFTADKPVLFAYHSYAQDVRGLIYDRPNHDNFHVVGYKEQG 758 Query: 676 GAPSPFD 682 +PFD Sbjct: 759 STTTPFD 765 >3KNZ-A nrPDB Length = 366 Score = 31.2 bits (69), Expect = 1.6, Method: Compositional matrix adjust. Identities = 21/72 (29%), Positives = 34/72 (47%), Gaps = 3/72 (4%) Query: 102 RTREGRLKAACNLLQRGITNLCVIGGDGSLTG---ANLFRKEWSGLLEELARNGQIDKEA 158 +TRE +AA L +RG+T + + G S G A F + W L ++ +D E Sbjct: 33 QTREDLWRAAQALTERGVTRIILTGSGTSYHGALTARTFMQRWCALPVDVCWPFMLDDET 92 Query: 159 VQKYAYLNVVGM 170 + + VVG+ Sbjct: 93 LARSGKALVVGI 104 >5J54-A nrPDB Length = 494 Score = 30.0 bits (66), Expect = 3.8, Method: Compositional matrix adjust. Identities = 15/49 (30%), Positives = 27/49 (55%), Gaps = 3/49 (6%) Query: 238 FLP---ESPPEEGWEEQMCVKLSENRARKKRLNIIIVAEGAIDTQNKPI 283 F+P ++P +GW Q+C +L E R+ + + + +G + T N PI Sbjct: 421 FVPRAKDAPEGDGWIVQVCNRLEEQRSDLLIFDALDIEKGPVATVNIPI 469 >5N5S-A nrPDB Length = 515 Score = 30.0 bits (66), Expect = 4.3, Method: Compositional matrix adjust. Identities = 35/144 (24%), Positives = 54/144 (37%), Gaps = 22/144 (15%) Query: 619 VEHLTEKMKTTIQR----GLVLRNESCSENYTTDFIYQLYSEEGKGVFDCRKNVLGHMQQ 674 V+ + TIQR G +SC +LY E +G K + + Sbjct: 294 VDDYVPDLDYTIQRLINGGFYQGGQSCIHMQRLYVHERLYDEVKEGFVAAVKKL-----K 348 Query: 675 GGAPSPFDRNFGTKISARAMEWITAKLKEARGRGKKFTTD-------------DSICVLG 721 G P D G IS A + I +KEA +G K T + + + Sbjct: 349 MGNPFEEDTYLGPMISESAAKGIEDWVKEAVAKGGKLLTGGNRKGAFIEPTVIEDVPIEA 408 Query: 722 ISKRNVIFQPVAELKKQTDFEHRI 745 +++ IF PV L K +DF+ + Sbjct: 409 NARKEEIFGPVVLLYKYSDFKEAV 432 >3SLH-A nrPDB Length = 441 Score = 28.9 bits (63), Expect = 9.6, Method: Compositional matrix adjust. Identities = 19/78 (24%), Positives = 32/78 (41%) Query: 399 IKLPDDQIPKTNCNVAVINVGAPAAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQI 458 I +P DQ+P T V+ + A A +R A + + + R+ A+ DG Sbjct: 306 IDIPPDQVPLTIDEFPVLLIAAAVAQGKTVLRDAAELRVKETDRIAAMVDGLQKLGIAAE 365 Query: 459 KEIGWTDVGGWTGQGGSI 476 + G T +GG + Sbjct: 366 SLPDGVIIQGGTLEGGEV 383 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 4XYJ-A nrPDB 1148 0.0 3O8N-A nrPDB 1015 0.0 3OPY-B nrPDB 973 0.0 3OPY-A nrPDB 960 0.0 3O8O-B nrPDB 927 0.0 3O8O-A nrPDB 923 0.0 4A3S-A nrPDB 378 e-105 4I4I-A nrPDB 375 e-104 5XZ7-A nrPDB 358 4e-99 1PFK-A nrPDB 351 8e-97 1ZXX-A nrPDB 347 1e-95 2HIG-A nrPDB 296 2e-80 3K2Q-A nrPDB 218 8e-57 1KZH-A nrPDB 214 1e-55 3HNO-A nrPDB 184 2e-46 Sequences not found previously or not previously below threshold: 5FHY-A nrPDB 35 0.13 4MCA-A nrPDB 34 0.19 3KNZ-A nrPDB 33 0.58 4RGQ-A nrPDB 32 0.93 5LX9-A nrPDB 32 0.96 4RFL-A nrPDB 32 1.2 6B9O-A nrPDB 30 3.5 4BHD-A nrPDB 30 4.1 CONVERGED! >4XYJ-A nrPDB Length = 812 Score = 1148 bits (2969), Expect = 0.0, Method: Composition-based stats. Identities = 784/784 (100%), Positives = 784/784 (100%) Query: 1 MDADDSRAPKGSLRKFLEHLSGAGKAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFI 60 MDADDSRAPKGSLRKFLEHLSGAGKAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFI Sbjct: 29 MDADDSRAPKGSLRKFLEHLSGAGKAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFI 88 Query: 61 YEGYQGMVDGGSNIAEADWESVSSILQVGGTIIGSARCQAFRTREGRLKAACNLLQRGIT 120 YEGYQGMVDGGSNIAEADWESVSSILQVGGTIIGSARCQAFRTREGRLKAACNLLQRGIT Sbjct: 89 YEGYQGMVDGGSNIAEADWESVSSILQVGGTIIGSARCQAFRTREGRLKAACNLLQRGIT 148 Query: 121 NLCVIGGDGSLTGANLFRKEWSGLLEELARNGQIDKEAVQKYAYLNVVGMVGSIDNDFCG 180 NLCVIGGDGSLTGANLFRKEWSGLLEELARNGQIDKEAVQKYAYLNVVGMVGSIDNDFCG Sbjct: 149 NLCVIGGDGSLTGANLFRKEWSGLLEELARNGQIDKEAVQKYAYLNVVGMVGSIDNDFCG 208 Query: 181 TDMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLP 240 TDMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLP Sbjct: 209 TDMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLP 268 Query: 241 ESPPEEGWEEQMCVKLSENRARKKRLNIIIVAEGAIDTQNKPITSEKIKELVVTQLGYDT 300 ESPPEEGWEEQMCVKLSENRARKKRLNIIIVAEGAIDTQNKPITSEKIKELVVTQLGYDT Sbjct: 269 ESPPEEGWEEQMCVKLSENRARKKRLNIIIVAEGAIDTQNKPITSEKIKELVVTQLGYDT 328 Query: 301 RVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEATPDTPACVVSLNGNHAVRLPLMEC 360 RVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEATPDTPACVVSLNGNHAVRLPLMEC Sbjct: 329 RVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEATPDTPACVVSLNGNHAVRLPLMEC 388 Query: 361 VQMTQDVQKAMDERRFQDAVRLRGRSFAGNLNTYKRLAIKLPDDQIPKTNCNVAVINVGA 420 VQMTQDVQKAMDERRFQDAVRLRGRSFAGNLNTYKRLAIKLPDDQIPKTNCNVAVINVGA Sbjct: 389 VQMTQDVQKAMDERRFQDAVRLRGRSFAGNLNTYKRLAIKLPDDQIPKTNCNVAVINVGA 448 Query: 421 PAAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGTK 480 PAAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGTK Sbjct: 449 PAAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGTK 508 Query: 481 RVLPGKYLEEIATQMRTHSINALLIIGGFEAYLGLLELSAAREKHEEFCVPMVMVPATVS 540 RVLPGKYLEEIATQMRTHSINALLIIGGFEAYLGLLELSAAREKHEEFCVPMVMVPATVS Sbjct: 509 RVLPGKYLEEIATQMRTHSINALLIIGGFEAYLGLLELSAAREKHEEFCVPMVMVPATVS 568 Query: 541 NNVPGSDFSIGADTALNTITDTCDRIKQSASGTKRRVFIIETMGGYCGYLANMGGLAAGA 600 NNVPGSDFSIGADTALNTITDTCDRIKQSASGTKRRVFIIETMGGYCGYLANMGGLAAGA Sbjct: 569 NNVPGSDFSIGADTALNTITDTCDRIKQSASGTKRRVFIIETMGGYCGYLANMGGLAAGA 628 Query: 601 DAAYIFEEPFDIRDLQSNVEHLTEKMKTTIQRGLVLRNESCSENYTTDFIYQLYSEEGKG 660 DAAYIFEEPFDIRDLQSNVEHLTEKMKTTIQRGLVLRNESCSENYTTDFIYQLYSEEGKG Sbjct: 629 DAAYIFEEPFDIRDLQSNVEHLTEKMKTTIQRGLVLRNESCSENYTTDFIYQLYSEEGKG 688 Query: 661 VFDCRKNVLGHMQQGGAPSPFDRNFGTKISARAMEWITAKLKEARGRGKKFTTDDSICVL 720 VFDCRKNVLGHMQQGGAPSPFDRNFGTKISARAMEWITAKLKEARGRGKKFTTDDSICVL Sbjct: 689 VFDCRKNVLGHMQQGGAPSPFDRNFGTKISARAMEWITAKLKEARGRGKKFTTDDSICVL 748 Query: 721 GISKRNVIFQPVAELKKQTDFEHRIPKEQWWLKLRPLMKILAKYKASYDVSDSGQLEHVQ 780 GISKRNVIFQPVAELKKQTDFEHRIPKEQWWLKLRPLMKILAKYKASYDVSDSGQLEHVQ Sbjct: 749 GISKRNVIFQPVAELKKQTDFEHRIPKEQWWLKLRPLMKILAKYKASYDVSDSGQLEHVQ 808 Query: 781 PWSV 784 PWSV Sbjct: 809 PWSV 812 >3O8N-A nrPDB Length = 762 Score = 1015 bits (2625), Expect = 0.0, Method: Composition-based stats. Identities = 544/752 (72%), Positives = 637/752 (84%), Gaps = 4/752 (0%) Query: 22 GAGKAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGGSNIAEADWES 81 G GKAI VLTSGGDAQGMNAAVRAVVR+GI+ GA+V+F++EGYQG+VDGG +I EA WES Sbjct: 13 GVGKAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGGDHIREATWES 72 Query: 82 VSSILQVGGTIIGSARCQAFRTREGRLKAACNLLQRGITNLCVIGGDGSLTGANLFRKEW 141 VS +LQ+GGT+IGSARC+ FR REGRL+AA NL++RGITNLCVIGGDGSLTGA+ FR EW Sbjct: 73 VSMMLQLGGTVIGSARCKDFREREGRLRAAHNLVKRGITNLCVIGGDGSLTGADTFRSEW 132 Query: 142 SGLLEELARNGQIDKEAVQKYAYLNVVGMVGSIDNDFCGTDMTIGTDSALHRIIEVVDAI 201 S LL +L + G+I E + +YLN+VG+VGSIDNDFCGTDMTIGTDSALHRI E+VDAI Sbjct: 133 SDLLSDLQKAGKITAEEATRSSYLNIVGLVGSIDNDFCGTDMTIGTDSALHRITEIVDAI 192 Query: 202 MTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEEGWEEQMCVKLSENRA 261 TTAQSHQRTFVLEVMGRHCGYLALV++L+CGADWVF+PE PP++ WE+ +C +LSE R Sbjct: 193 TTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDDNWEDHLCRRLSETRT 252 Query: 262 RKKRLNIIIVAEGAIDTQNKPITSEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRIL 321 R RLNIIIVAEGAID KPITSE +K+LVV +LGYDTRVT+LGHVQRGGTPSAFDRIL Sbjct: 253 RGSRLNIIIVAEGAIDRNGKPITSEGVKDLVVRRLGYDTRVTVLGHVQRGGTPSAFDRIL 312 Query: 322 ASRMGVEAVIALLEATPDTPACVVSLNGNHAVRLPLMECVQMTQDVQKAMDERRFQDAVR 381 SRMGVEAV+ALLE TPDTPACVVSL+GN AVRLPLMECVQ+T+DV KAMDE+RF +A++ Sbjct: 313 GSRMGVEAVMALLEGTPDTPACVVSLSGNQAVRLPLMECVQVTKDVTKAMDEKRFDEAMK 372 Query: 382 LRGRSFAGNLNTYKRLAIKLPDDQIPKT-NCNVAVINVGAPAAGMNAAVRSAVRVGIADG 440 LRGRSF N YK LA P PK+ + VAV+NVGAPAAGMNAAVRS VR+G+ G Sbjct: 373 LRGRSFMNNWEVYKLLAHIRPP--APKSGSYTVAVMNVGAPAAGMNAAVRSTVRIGLIQG 430 Query: 441 HRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGTKRVLPGKYLEEIATQMRTHSI 500 +R+L ++DGF+G AKGQI+E GW+ VGGWTGQGGS LG+KR LP K E+I+ + +I Sbjct: 431 NRVLVVHDGFEGPAKGQIEEAGWSYVGGWTGQGGSKLGSKRTLPKKSFEQISANITKFNI 490 Query: 501 NALLIIGGFEAYLGLLELSAAREKHEEFCVPMVMVPATVSNNVPGSDFSIGADTALNTIT 560 L+IIGGFEAY G LEL R++ +E C+P V++PATVSNNVPGSDFS+GADTALNTI Sbjct: 491 QGLVIIGGFEAYTGGLELMEGRKQFDELCIPFVVIPATVSNNVPGSDFSVGADTALNTIC 550 Query: 561 DTCDRIKQSASGTKRRVFIIETMGGYCGYLANMGGLAAGADAAYIFEEPFDIRDLQSNVE 620 TCDRIKQSA+GTKRRVFIIETMGGYCGYLA M GLAAGADAAYIFEEPF IRDLQ+NVE Sbjct: 551 TTCDRIKQSAAGTKRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDLQANVE 610 Query: 621 HLTEKMKTTIQRGLVLRNESCSENYTTDFIYQLYSEEGKGVFDCRKNVLGHMQQGGAPSP 680 HL +KMKTT++RGLVLRNE C+ENYTTDFI+ LYSEEGKG+FD RKNVLGHMQQGG+P+P Sbjct: 611 HLVQKMKTTVKRGLVLRNEKCNENYTTDFIFNLYSEEGKGIFDSRKNVLGHMQQGGSPTP 670 Query: 681 FDRNFGTKISARAMEWITAKLKEARGRGKKF-TTDDSICVLGISKRNVIFQPVAELKKQT 739 FDRNF TK+ A+AM W+ K+KE+ G+ F T DS CVLG+ KR ++FQPV EL+ QT Sbjct: 671 FDRNFATKMGAKAMNWMAGKIKESYRNGRIFANTPDSGCVLGMRKRALVFQPVTELQNQT 730 Query: 740 DFEHRIPKEQWWLKLRPLMKILAKYKASYDVS 771 DFEHRIPKEQWWLKLRP++KILAKY+ D S Sbjct: 731 DFEHRIPKEQWWLKLRPILKILAKYEIDLDTS 762 >3OPY-B nrPDB Length = 941 Score = 973 bits (2516), Expect = 0.0, Method: Composition-based stats. Identities = 325/760 (42%), Positives = 465/760 (61%), Gaps = 17/760 (2%) Query: 20 LSGAGKAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGG-SNIAEAD 78 L+ K IGV+TSGGD+ GMN VRAVVR GIY G KV+ I+EGY+G+V GG I E Sbjct: 177 LNPVRKTIGVMTSGGDSPGMNPFVRAVVRAGIYKGCKVFCIHEGYEGLVRGGEKYIKETQ 236 Query: 79 WESVSSILQVGGTIIGSARCQAFRTREGRLKAACNLLQRGITNLCVIGGDGSLTGANLFR 138 W V L GGT IG+ARC+ FR R GRLKA N++ GI L V GGDGSLTGA+ FR Sbjct: 237 WHDVRGWLVEGGTNIGTARCKEFRERSGRLKACKNMIDMGIDALIVCGGDGSLTGADRFR 296 Query: 139 KEWSGLLEELARNGQIDKEAVQKYAYLNVVGMVGSIDNDFCGTDMTIGTDSALHRIIEVV 198 EW L+EEL + QI ++ + LN+ G VGSIDND TD TIG S+L RI + Sbjct: 297 SEWPSLIEELLQTEQISQQQFNTHQNLNICGAVGSIDNDMSSTDATIGAFSSLDRICRAI 356 Query: 199 DAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEE-GWEEQMCVKLS 257 D I TA SH R F++EVMGRHCG+L L++ LA AD++ +PE P W++QMC + Sbjct: 357 DYIDATANSHSRAFIVEVMGRHCGWLGLLAGLATSADYILIPEKPASSREWQDQMCDIVG 416 Query: 258 ENRARKKRLNIIIVAEGAIDTQNKPITSEKIKELVVTQLGYDTRVTILGHVQRGGTPSAF 317 ++RAR KR I+IVAEGAI PI+ +++K+++V +LG DTRVT LGHVQRGGT AF Sbjct: 417 KHRARGKRKTIVIVAEGAISNDLSPISCDQVKDVLVNRLGLDTRVTTLGHVQRGGTAVAF 476 Query: 318 DRILASRMGVEAVIALLEATPDTPACVVSLNGNHAVRLPLMECVQMTQDVQKAMDERRFQ 377 DRI A+ GVEAV A+LE DTP+ ++++ + R+PL++ V++TQ V K+++ R F+ Sbjct: 477 DRIYATLQGVEAVNAVLECDADTPSPMIAIKEDQITRVPLVDAVELTQQVAKSIESRNFK 536 Query: 378 DAVRLRGRSFAGNLNTY--KRLAIKLPDDQIPKTNCNVAVINVGAPAAGMNAAVRSAVRV 435 A+ LR F ++ + A +P + +A+INVGAPA GMN+AV S Sbjct: 537 KAISLRDSEFVEHMKNFISTNSADHVPPSLPLEKRKKIAIINVGAPAGGMNSAVYSMATY 596 Query: 436 GIADGHRMLAIYDGFDGFAKGQ-IKEIGWTDVGGWTGQGGSILGTKRVLPGK-YLEEIAT 493 ++ GH AI++GF G A+ + ++ I W D+ GW GGS +GT R LP + IA Sbjct: 597 CMSRGHVPYAIHNGFSGLARHESVRSINWLDIEGWGSLGGSEIGTNRTLPNDADIGMIAY 656 Query: 494 QMRTHSINALLIIGGFEAYLGLLELSAAREKHEEFCVPMVMVPATVSNNVPGSDFSIGAD 553 + + L+++GGFEA++ L +L AR + +P+V++PAT+SNNVPG+++S+G+D Sbjct: 657 FFEKYGFDGLILVGGFEAFISLHQLERARINYPSLRIPLVLIPATISNNVPGTEYSLGSD 716 Query: 554 TALNTITDTCDRIKQSASGTKRRVFIIETMGGYCGYLANMGGLAAGADAAYIFEEPFDIR 613 T LN+ + CD IKQSA+ T+ RVF++E GG GY+A LA GA +Y+ EE + Sbjct: 717 TCLNSFMEYCDVIKQSAAATRNRVFVVEVQGGNSGYIATHAQLACGAQISYVPEEGISLA 776 Query: 614 DLQSNVEHLTEKMKTTIQRG----LVLRNESCSENYTTDFIYQLYSEEGKGVFDCRKNVL 669 L+ ++ L E + L+L++E+ S+ TT+ I + +E G FD + + Sbjct: 777 QLEMDINSLKESFANDQGKTKSGRLILKSENASKVLTTEVISTIIDDEASGRFDSKTAIP 836 Query: 670 GHMQQGGAPSPFDRNFGTKISARAMEWITAKLKEAR--GRGKKFTTDDSI----CVLGIS 723 GH+QQGG PSP DR ++ + RA+ +I + F D I VLGI Sbjct: 837 GHVQQGGIPSPMDRVRASRFAIRAVSFIERHSDRCQTFKNSISFRQTDEITSTAVVLGIH 896 Query: 724 KRNVIFQPVAELKK-QTDFEHRIPKEQWWLKLRPLMKILA 762 K + F P+ +L ++D R+ K +W +R + +L+ Sbjct: 897 KSQLRFTPIRQLYDFESDVPRRMRKNIFWSNVREISDMLS 936 >3OPY-A nrPDB Length = 989 Score = 960 bits (2482), Expect = 0.0, Method: Composition-based stats. Identities = 346/775 (44%), Positives = 481/775 (62%), Gaps = 39/775 (5%) Query: 24 GKAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGGSNIAEADWESVS 83 K I ++TSGGDA GMNAAVRAV R GI+ G KVY YEGY G+V GG + E W+ V Sbjct: 210 KKKIAIITSGGDAPGMNAAVRAVTRAGIFYGCKVYACYEGYTGLVKGGDMLKELQWQDVR 269 Query: 84 SILQVGGTIIGSARCQAFRTREGRLKAACNLLQRGITNLCVIGGDGSLTGANLFRKEWSG 143 +L +GGTIIG+ARC+ FR R GRL+A N++ GI L V GGDGSLTGA+LFRKEW Sbjct: 270 GLLSIGGTIIGTARCKEFRERWGRLQACYNMVSNGIDALVVCGGDGSLTGADLFRKEWPE 329 Query: 144 LLEELARNGQIDKEAVQKYAYLNVVGMVGSIDNDFCGTDMTIGTDSALHRIIEVVDAIMT 203 L++EL +I KE + + L +VG+VGSIDND CGTD TIG S+L RIIE+VD I Sbjct: 330 LIKELLGEDKITKEQYETHRNLTIVGLVGSIDNDMCGTDSTIGAYSSLERIIELVDYIDA 389 Query: 204 TAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPP-EEGWEEQMCVKLSENRAR 262 TA SH R FV+EVMGRHCG+L L+S +A GAD++F+PE PP E W++ + +R + Sbjct: 390 TAASHSRAFVVEVMGRHCGWLGLMSGIATGADYIFIPERPPSESNWKDDLKKVCLRHREK 449 Query: 263 KKRLNIIIVAEGAIDTQNKPITSEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILA 322 +R +IVAEGAID Q PITSE++K+++V ++G DTR+T LGHVQRGG P AFDR LA Sbjct: 450 GRRKTTVIVAEGAIDDQLNPITSEEVKDVLV-EIGLDTRITRLGHVQRGGAPCAFDRFLA 508 Query: 323 SRMGVEAVIALLEATPDTPACVVSLNGNHAVRLPLMECVQMTQDVQKAMDERRFQDAVRL 382 + GV+AV A+LE+TP P+ V+S+ N VR PL+E V T+ V A++ + F A++L Sbjct: 509 TVQGVDAVRAVLESTPAIPSPVISILENKIVRQPLVESVAQTKTVSAAIEAKDFDKALQL 568 Query: 383 RGRSFAGNLNTYKRLAIKLPDD---QIPK-TNCNVAVINVGAPAAGMNAAVRSAVRVGIA 438 R + FA + + L++ DD +P+ + N+A+I+VGAP + +N A R A +A Sbjct: 569 RDQEFATSYENF--LSVSKYDDGSYLVPESSRLNIAIIHVGAPTSALNPATRVATLNSLA 626 Query: 439 DGHRMLAIYDGFDGFAK-GQIKEIGWTDVGGWTGQGGSILGTKRVLPGKYLEEIATQMRT 497 GHR+ AI +GF G + G ++E+ W DV W GGS +GT R LP + +A + Sbjct: 627 KGHRVFAIRNGFAGLIRHGAVRELNWIDVEDWHNTGGSEIGTNRSLPSDDMGTVAYYFQQ 686 Query: 498 HSINALLIIGGFEAYLGLLELSAAREKHEEFCVPMVMVPATVSNNVPGSDFSIGADTALN 557 + + L+IIGGFEA+ L EL AAR ++ F +PM +PATVSNNVPG+++S+G+DT LN Sbjct: 687 YKFDGLIIIGGFEAFTALYELDAARAQYPIFNIPMCCLPATVSNNVPGTEYSLGSDTCLN 746 Query: 558 TITDTCDRIKQSASGTKRRVFIIETMGGYCGYLANMGGLAAGADAAYIFEEPFDIRDLQS 617 T++ CD +KQSAS ++RR F++E GGY GYLA+ GL GA A Y E P +++ +Q Sbjct: 747 TLSGYCDAVKQSASASRRRTFVVEVQGGYSGYLASYAGLITGALAVYTPENPINLQTVQE 806 Query: 618 NVEHLTEKMKTTIQRG----LVLRNESCSENYTTDFIYQLYSEEGKGVFDCRKNVLGHMQ 673 ++E LT + + + + NE S+ YTTD I + E GKG F+ R V GH+Q Sbjct: 807 DIELLTRTYEEDDGKNRSGKIFIHNEKASKVYTTDLIAAIIGEAGKGRFESRTAVPGHVQ 866 Query: 674 QGGAPSPFDRNFGTKISARAMEWIT--------AKLKEARGRGKKFTTDDSI-------- 717 QG +PS DR +++ + +I A R +F DD + Sbjct: 867 QGKSPSSIDRVNACRLAIKCCNFIEDANFQVKHNANLSADERHLRFFYDDGVKTSAVSGK 926 Query: 718 ---------CVLGISKRNVIFQPVAEL-KKQTDFEHRIPKEQWWLKLRPLMKILA 762 V+GI V F PV +L + +T + R K W +L + +L+ Sbjct: 927 SSVIDDNTSVVIGIQGSEVTFTPVKQLWENETHHKWRKGKNVHWEQLNIVSDLLS 981 Score = 225 bits (573), Expect = 6e-59, Method: Composition-based stats. Identities = 90/313 (28%), Positives = 152/313 (48%), Gaps = 30/313 (9%) Query: 408 KTNCNVAVINVGAPAAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQ--IKEIGWTD 465 + +A+I G A GMNAAVR+ R GI G ++ A Y+G+ G KG +KE+ W D Sbjct: 208 EGKKKIAIITSGGDAPGMNAAVRAVTRAGIFYGCKVYACYEGYTGLVKGGDMLKELQWQD 267 Query: 466 VGGWTGQGGSILGTKRVLPG-KYLEEI--ATQMRTHSINALLIIGGFEAYLGLLELSA-- 520 V G GG+I+GT R + + M ++ I+AL++ GG + G Sbjct: 268 VRGLLSIGGTIIGTARCKEFRERWGRLQACYNMVSNGIDALVVCGGDGSLTGADLFRKEW 327 Query: 521 -------------AREKHEEF-CVPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRI 566 +E++E + +V + ++ N++ G+D +IGA ++L I + D I Sbjct: 328 PELIKELLGEDKITKEQYETHRNLTIVGLVGSIDNDMCGTDSTIGAYSSLERIIELVDYI 387 Query: 567 KQSASGTKRRVFIIETMGGYCGYLANMGGLAAGADAAYIFEEPFDIRDLQSNVEH-LTEK 625 + + + R F++E MG +CG+L M G+A GAD +I E P + + +++ Sbjct: 388 -DATAASHSRAFVVEVMGRHCGWLGLMSGIATGADYIFIPERPPSESNWKDDLKKVCLRH 446 Query: 626 MKTTIQRGLVLRNESCSENY----TTDFIYQLYSEEGKGVFDCRKNVLGHMQQGGAPSPF 681 + ++ V+ E ++ T++ + + E G D R LGH+Q+GGAP F Sbjct: 447 REKGRRKTTVIVAEGAIDDQLNPITSEEVKDVLVEIG---LDTRITRLGHVQRGGAPCAF 503 Query: 682 DRNFGTKISARAM 694 DR T A+ Sbjct: 504 DRFLATVQGVDAV 516 >3O8O-B nrPDB Length = 766 Score = 927 bits (2396), Expect = 0.0, Method: Composition-based stats. Identities = 326/759 (42%), Positives = 479/759 (63%), Gaps = 23/759 (3%) Query: 24 GKAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGGSN-IAEADWESV 82 KAI V+TSGGDA GMN+ VRA+VR I+ G + + + EGY+G+V GG I E WE V Sbjct: 3 QKAIAVMTSGGDAPGMNSNVRAIVRSAIFKGCRAFVVMEGYEGLVRGGPEYIKEFHWEDV 62 Query: 83 SSILQVGGTIIGSARCQAFRTREGRLKAACNLLQRGITNLCVIGGDGSLTGANLFRKEWS 142 GGT IG+ARC F+ REGRL A +L++ G+ L V GGDGSLTGA+LFR EW Sbjct: 63 RGWSAEGGTNIGTARCMEFKKREGRLLGAQHLIEAGVDALIVCGGDGSLTGADLFRSEWP 122 Query: 143 GLLEELARNGQIDKEAVQKYAYLNVVGMVGSIDNDFCGTDMTIGTDSALHRIIEVVDAIM 202 L+EEL + +I E ++ +LN+ G VGSIDND TD TIG SAL RI + +D + Sbjct: 123 SLIEELLKTNRISNEQYERMKHLNICGTVGSIDNDMSTTDATIGAYSALDRICKAIDYVE 182 Query: 203 TTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEEG-WEEQMCVKLSENRA 261 TA SH R FV+EVMGR+CG+LAL++ +A AD++F+PE P W++QMC +S++R+ Sbjct: 183 ATANSHSRAFVVEVMGRNCGWLALLAGIATSADYIFIPEKPATSSEWQDQMCDIVSKHRS 242 Query: 262 RKKRLNIIIVAEGAIDTQNKPITSEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRIL 321 R KR I++VAEGAI PI+ + +++V +LG DTR+T LGHVQRGGT A+DRIL Sbjct: 243 RGKRTTIVVVAEGAIAADLTPISPSDVHKVLVDRLGLDTRITTLGHVQRGGTAVAYDRIL 302 Query: 322 ASRMGVEAVIALLEATPDTPACVVSLNGNHAVRLPLMECVQMTQDVQKAMDERRFQDAVR 381 A+ G+EAV A+LE+TPDTP+ ++++N N VR PLME V++T+ V +A+ + F+ A+ Sbjct: 303 ATLQGLEAVNAVLESTPDTPSPLIAVNENKIVRKPLMESVKLTKAVAEAIQAKDFKRAMS 362 Query: 382 LRGRSFAGNLNTYKRLAIKLPDDQIPK----TNCNVAVINVGAPAAGMNAAVRSAVRVGI 437 LR F +LN + +AI D PK +A++NVGAPA G+N+AV S + Sbjct: 363 LRDTEFIEHLNNF--MAINSADHNEPKLPKDKRLKIAIVNVGAPAGGINSAVYSMATYCM 420 Query: 438 ADGHRMLAIYDGFDGFAKGQ-IKEIGWTDVGGWTGQGGSILGTKRVLPGK-YLEEIATQM 495 + GHR AIY+G+ G A+ + ++ + W D+ GW +GGS +GT RV P + L IA Sbjct: 421 SQGHRPYAIYNGWSGLARHESVRSLNWKDMLGWQSRGGSEIGTNRVTPEEADLGMIAYYF 480 Query: 496 RTHSINALLIIGGFEAYLGLLELSAAREKHEEFCVPMVMVPATVSNNVPGSDFSIGADTA 555 + + + L+I+GGFEA+ L +L ARE + F +PMV++PAT+SNNVPG+++S+G+DTA Sbjct: 481 QKYEFDGLIIVGGFEAFESLHQLERARESYPAFRIPMVLIPATLSNNVPGTEYSLGSDTA 540 Query: 556 LNTITDTCDRIKQSASGTKRRVFIIETMGGYCGYLANMGGLAAGADAAYIFEEPFDIRDL 615 LN + + CD +KQSAS T+ R F+++ GG GYLA LA GA +Y+ EE + L Sbjct: 541 LNALMEYCDVVKQSASSTRGRAFVVDCQGGNSGYLATYASLAVGAQVSYVPEEGISLEQL 600 Query: 616 QSNVEHLTEKMKTTIQRG----LVLRNESCSENYTTDFIYQLYSEEGKGVFDCRKNVLGH 671 ++E+L + + RG L+L++ + S+ + + ++ + E G FD + GH Sbjct: 601 SEDIEYLAQSFEKAEGRGRFGKLILKSTNASKALSATKLAEVITAEADGRFDAKPAYPGH 660 Query: 672 MQQGGAPSPFDRNFGTKISARAMEWITAK---LKEARGRGKKFTTD-----DSICVLGIS 723 +QQGG PSP DR T+++ +A+ +I + EAR + F D D+ V+G+ Sbjct: 661 VQQGGLPSPIDRTRATRMAIKAVGFIKDNQAAIAEARAAEENFNADDKTISDTAAVVGVK 720 Query: 724 KRNVIFQPVAEL-KKQTDFEHRIPKEQWWLKLRPLMKIL 761 +V++ + +L +T+ R+PK W R + L Sbjct: 721 GSHVVYNSIRQLYDYETEVSMRMPKVIHWQATRLIADHL 759 >3O8O-A nrPDB Length = 787 Score = 923 bits (2385), Expect = 0.0, Method: Composition-based stats. Identities = 330/769 (42%), Positives = 478/769 (62%), Gaps = 33/769 (4%) Query: 24 GKAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGGSNIAEADWESVS 83 K I V+TSGGD+ GMNAAVRAVVR GI+ G V+ +YEGY+G++ GG + + WE V Sbjct: 5 KKKIAVMTSGGDSPGMNAAVRAVVRTGIHFGCDVFAVYEGYEGLLRGGKYLKKMAWEDVR 64 Query: 84 SILQVGGTIIGSARCQAFRTREGRLKAACNLLQRGITNLCVIGGDGSLTGANLFRKEWSG 143 L GGT+IG+AR FR REGR +AA NL+ +GI L V GGDGSLTGA+LFR EW Sbjct: 65 GWLSEGGTLIGTARSMEFRKREGRRQAAGNLISQGIDALVVCGGDGSLTGADLFRHEWPS 124 Query: 144 LLEELARNGQIDKEAVQKYAYLNVVGMVGSIDNDFCGTDMTIGTDSALHRIIEVVDAIMT 203 L++EL G+ KE V Y L++VG+VGSIDND GTD TIG SAL RI E+VD I Sbjct: 125 LVDELVAEGRFTKEEVAPYKNLSIVGLVGSIDNDMSGTDSTIGAYSALERICEMVDYIDA 184 Query: 204 TAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPES-PPEEGWEEQMCVKLSENRAR 262 TA+SH R FV+EVMGRHCG+LAL++ +A GAD++F+PE P W++++ +R++ Sbjct: 185 TAKSHSRAFVVEVMGRHCGWLALMAGIATGADYIFIPERAVPHGKWQDELKEVCQRHRSK 244 Query: 263 KKRLNIIIVAEGAIDTQNKPITSEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILA 322 +R N IIVAEGA+D Q P+T+ +K+ ++ +LG DT+VTILGHVQRGGT A DR LA Sbjct: 245 GRRNNTIIVAEGALDDQLNPVTANDVKDALI-ELGLDTKVTILGHVQRGGTAVAHDRWLA 303 Query: 323 SRMGVEAVIALLEATPDTPACVVSLNGNHAVRLPLMECVQMTQDVQKAMDERRFQDAVRL 382 + GV+AV A+LE TP+TP+ ++ + N +R+PL+E V++T+ V A++ + F A+ L Sbjct: 304 TLQGVDAVKAVLEFTPETPSPLIGILENKIIRMPLVESVKLTKSVATAIENKDFDKAISL 363 Query: 383 RGRSFAGNLNTYKRLAIKLPDD---QIPKT-NCNVAVINVGAPAAGMNAAVRSAVRVGIA 438 R F + L+ + DD +P + N+ +++VGAP+A +NAA R+A ++ Sbjct: 364 RDTEFIELYENF--LSTTVKDDGSELLPVSDRLNIGIVHVGAPSAALNAATRAATLYCLS 421 Query: 439 DGHRMLAIYDGFDGFAK-GQIKEIGWTDVGGWTGQGGSILGTKRVLPGKYLEEIATQMRT 497 GH+ AI +GF G + G++KE+ W DV W GGS +GT R + + L IA + Sbjct: 422 HGHKPYAIMNGFSGLIQTGEVKELSWIDVENWHNLGGSEIGTNRSVASEDLGTIAYYFQK 481 Query: 498 HSINALLIIGGFEAYLGLLELSAAREKHEEFCVPMVMVPATVSNNVPGSDFSIGADTALN 557 + ++ L+I+GGFE + L +L R +H F +PM ++PATVSNNVPG+++S+G DT LN Sbjct: 482 NKLDGLIILGGFEGFRSLKQLRDGRTQHPIFNIPMCLIPATVSNNVPGTEYSLGVDTCLN 541 Query: 558 TITDTCDRIKQSASGTKRRVFIIETMGGYCGYLANMGGLAAGADAAYIFEEPFDIRDLQS 617 + + D IKQSAS T+RRVF+ E GG+ GY+A+ GL GA + Y E+ D+ ++ Sbjct: 542 ALVNYTDDIKQSASATRRRVFVCEVQGGHSGYIASFTGLITGAVSVYTPEKKIDLASIRE 601 Query: 618 NVEHLTEKMKTTIQRG----LVLRNESCSENYTTDFIYQLYSEEGKGVFDCRKNVLGHMQ 673 ++ L E + L++RNE S Y+T + + SE KG F R + GH+Q Sbjct: 602 DITLLKENFRHDKGENRNGKLLVRNEQASSVYSTQLLADIISEASKGKFGVRTAIPGHVQ 661 Query: 674 QGGAPSPFDRNFGTKISARAMEWITA--KLKEA-------------RGRGKKFTT----D 714 QGG PS DR ++ + + +++I K EA G+K T D Sbjct: 662 QGGVPSSKDRVTASRFAVKCIKFIEQWNKKNEASPNTDAKVLRFKFDTHGEKVPTVEHED 721 Query: 715 DSICVLGISKRNVIFQPVAEL-KKQTDFEHRIPKEQWWLKLRPLMKILA 762 DS V+ ++ +V F+P+A L + +T+ E R E W + + IL+ Sbjct: 722 DSAAVICVNGSHVSFKPIANLWENETNVELRKGFEVHWAEYNKIGDILS 770 Score = 224 bits (572), Expect = 9e-59, Method: Composition-based stats. Identities = 88/314 (28%), Positives = 157/314 (50%), Gaps = 30/314 (9%) Query: 408 KTNCNVAVINVGAPAAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQ--IKEIGWTD 465 + +AV+ G + GMNAAVR+ VR GI G + A+Y+G++G +G +K++ W D Sbjct: 3 QKKKKIAVMTSGGDSPGMNAAVRAVVRTGIHFGCDVFAVYEGYEGLLRGGKYLKKMAWED 62 Query: 466 VGGWTGQGGSILGTKRVLPGKYLE---EIATQMRTHSINALLIIGGFEAYLGL------- 515 V GW +GG+++GT R + + E + A + + I+AL++ GG + G Sbjct: 63 VRGWLSEGGTLIGTARSMEFRKREGRRQAAGNLISQGIDALVVCGGDGSLTGADLFRHEW 122 Query: 516 -----LELSAAREKHEE----FCVPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRI 566 ++ R EE + +V + ++ N++ G+D +IGA +AL I + D I Sbjct: 123 PSLVDELVAEGRFTKEEVAPYKNLSIVGLVGSIDNDMSGTDSTIGAYSALERICEMVDYI 182 Query: 567 KQSASGTKRRVFIIETMGGYCGYLANMGGLAAGADAAYIFEEPFDIRDLQSNVEHLTEKM 626 + + + R F++E MG +CG+LA M G+A GAD +I E Q ++ + ++ Sbjct: 183 -DATAKSHSRAFVVEVMGRHCGWLALMAGIATGADYIFIPERAVPHGKWQDELKEVCQRH 241 Query: 627 KTTIQR-GLVLRNESCSENY----TTDFIYQLYSEEGKGVFDCRKNVLGHMQQGGAPSPF 681 ++ +R ++ E ++ T + + E G D + +LGH+Q+GG Sbjct: 242 RSKGRRNNTIIVAEGALDDQLNPVTANDVKDALIELG---LDTKVTILGHVQRGGTAVAH 298 Query: 682 DRNFGTKISARAME 695 DR T A++ Sbjct: 299 DRWLATLQGVDAVK 312 >4A3S-A nrPDB Length = 319 Score = 378 bits (971), Expect = e-105, Method: Composition-based stats. Identities = 145/347 (41%), Positives = 200/347 (57%), Gaps = 38/347 (10%) Query: 25 KAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGGSNIAEADWESVSS 84 K IGVLTSGGD+ GMNAAVRAVVR IY +VY IY GY G++ G I + + SV Sbjct: 2 KRIGVLTSGGDSPGMNAAVRAVVRKAIYHDVEVYGIYNGYAGLISG--KIEKLELGSVGD 59 Query: 85 ILQVGGTIIGSARCQAFRTREGRLKAACNLLQRGITNLCVIGGDGSLTGANLFRKEWSGL 144 I+ GGT + +ARC F+T EGR K NL + GI L VIGGDGS GA Sbjct: 60 IIHRGGTKLYTARCPEFKTVEGREKGIANLKKLGIEGLVVIGGDGSYMGA---------- 109 Query: 145 LEELARNGQIDKEAVQKYAYLNVVGMVGSIDNDFCGTDMTIGTDSALHRIIEVVDAIMTT 204 ++L +G VG+ G+IDND GTD TIG D+AL+ +I+ +D I T Sbjct: 110 -KKLTEHG------------FPCVGVPGTIDNDIPGTDFTIGFDTALNTVIDAIDKIRDT 156 Query: 205 AQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEEGWEEQMCVKLSENRARKK 264 A SH+RT+V+EVMGRH G +AL + LA GA+ + +PE+ + ++ +L R K Sbjct: 157 ATSHERTYVIEVMGRHAGDIALWAGLAGGAESILIPEADYD---MHEIIARLKRGHERGK 213 Query: 265 RLNIIIVAEGAIDTQNKPITSEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILASR 324 + +IIIVAEG + + + + + +TRV++LGH+QRGG+PSA DR+LASR Sbjct: 214 KHSIIIVAEGVG-------SGVEFGKRIEEETNLETRVSVLGHIQRGGSPSAADRVLASR 266 Query: 325 MGVEAVIALLEATPDTPACVVSLNGNHAVRLPLMECVQMTQDVQKAM 371 +G AV LLE V + N V ++E ++ V++ M Sbjct: 267 LGAYAVELLLEGKGGR---CVGIQNNKLVDHDIIEILETKHTVEQNM 310 Score = 358 bits (918), Expect = 6e-99, Method: Composition-based stats. Identities = 102/333 (30%), Positives = 175/333 (52%), Gaps = 23/333 (6%) Query: 411 CNVAVINVGAPAAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWT 470 + V+ G + GMNAAVR+ VR I + IY+G+ G G+I+++ VG Sbjct: 2 KRIGVLTSGGDSPGMNAAVRAVVRKAIYHDVEVYGIYNGYAGLISGKIEKLELGSVGDII 61 Query: 471 GQGGSILGTKRVLPGKYL---EEIATQMRTHSINALLIIGGFEAYLGLLELSAAREKHEE 527 +GG+ L T R K + E+ ++ I L++IGG +Y+G +L+ E Sbjct: 62 HRGGTKLYTARCPEFKTVEGREKGIANLKKLGIEGLVVIGGDGSYMGAKKLT-------E 114 Query: 528 FCVPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRIKQSASGTKRRVFIIETMGGYC 587 P V VP T+ N++PG+DF+IG DTALNT+ D D+I+ +A+ + R ++IE MG + Sbjct: 115 HGFPCVGVPGTIDNDIPGTDFTIGFDTALNTVIDAIDKIRDTAT-SHERTYVIEVMGRHA 173 Query: 588 GYLANMGGLAAGADAAYIFEEPFDIRDLQSNVEHLTEKMKTTIQRGLVLRNESCSENYTT 647 G +A GLA GA++ I E +D+ ++ + ++ E+ K + +++ E Sbjct: 174 GDIALWAGLAGGAESILIPEADYDMHEIIARLKRGHERGK---KHSIIIVAEGVGSG--V 228 Query: 648 DFIYQLYSEEGKGVFDCRKNVLGHMQQGGAPSPFDRNFGTKISARAME-WITAKLKEARG 706 +F ++ E + R +VLGH+Q+GG+PS DR +++ A A+E + K G Sbjct: 229 EFGKRIEEETN---LETRVSVLGHIQRGGSPSAADRVLASRLGAYAVELLLEGKGGRCVG 285 Query: 707 -RGKKFTTDDSICVLGISKRNVIFQPVAELKKQ 738 + K D I +L ++ + Q + +L K+ Sbjct: 286 IQNNKLVDHDIIEIL--ETKHTVEQNMYQLSKE 316 >4I4I-A nrPDB Length = 319 Score = 375 bits (962), Expect = e-104, Method: Composition-based stats. Identities = 146/347 (42%), Positives = 199/347 (57%), Gaps = 38/347 (10%) Query: 25 KAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGGSNIAEADWESVSS 84 K IGVLTSGGD+ GMNAA+R+VVR IY G +VY +Y GY G++ G NI + + V Sbjct: 2 KRIGVLTSGGDSPGMNAAIRSVVRKAIYHGVEVYGVYHGYAGLIAG--NIKKLEVGDVGD 59 Query: 85 ILQVGGTIIGSARCQAFRTREGRLKAACNLLQRGITNLCVIGGDGSLTGANLFRKEWSGL 144 I+ GGTI+ +ARC F+T EG+ K L + GI L VIGGDGS GA Sbjct: 60 IIHRGGTILYTARCPEFKTEEGQKKGIEQLKKHGIEGLVVIGGDGSYQGA---------- 109 Query: 145 LEELARNGQIDKEAVQKYAYLNVVGMVGSIDNDFCGTDMTIGTDSALHRIIEVVDAIMTT 204 ++L +G VG+ G+IDND GTD TIG D+AL+ +I+ +D I Sbjct: 110 -KKLTEHG------------FPCVGVPGTIDNDIPGTDFTIGFDTALNTVIDAIDKIRDA 156 Query: 205 AQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEEGWEEQMCVKLSENRARKK 264 A SH+RT+V+EVMGRH G +AL S LA GA+ + +PE+ + + +L R K Sbjct: 157 ATSHERTYVIEVMGRHAGDIALWSGLAGGAETILIPEADYD---MNDVIARLKRGHERGK 213 Query: 265 RLNIIIVAEGAIDTQNKPITSEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILASR 324 + +IIIVAEG + +I+E G++TRVT+LGHVQRGG+P+AFDR+LASR Sbjct: 214 KHSIIIVAEGVGSGVD---FGRQIQEA----TGFETRVTVLGHVQRGGSPTAFDRVLASR 266 Query: 325 MGVEAVIALLEATPDTPACVVSLNGNHAVRLPLMECVQMTQDVQKAM 371 +G AV LLE V + N V + E + + + M Sbjct: 267 LGARAVELLLEGKGGR---CVGIQNNQLVDHDIAEALANKHTIDQRM 310 Score = 353 bits (905), Expect = 2e-97, Method: Composition-based stats. Identities = 111/333 (33%), Positives = 174/333 (52%), Gaps = 23/333 (6%) Query: 411 CNVAVINVGAPAAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWT 470 + V+ G + GMNAA+RS VR I G + +Y G+ G G IK++ DVG Sbjct: 2 KRIGVLTSGGDSPGMNAAIRSVVRKAIYHGVEVYGVYHGYAGLIAGNIKKLEVGDVGDII 61 Query: 471 GQGGSILGTKRVLPGKYLE---EIATQMRTHSINALLIIGGFEAYLGLLELSAAREKHEE 527 +GG+IL T R K E + Q++ H I L++IGG +Y G +L+ E Sbjct: 62 HRGGTILYTARCPEFKTEEGQKKGIEQLKKHGIEGLVVIGGDGSYQGAKKLT-------E 114 Query: 528 FCVPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRIKQSASGTKRRVFIIETMGGYC 587 P V VP T+ N++PG+DF+IG DTALNT+ D D+I+ +A+ + R ++IE MG + Sbjct: 115 HGFPCVGVPGTIDNDIPGTDFTIGFDTALNTVIDAIDKIRDAAT-SHERTYVIEVMGRHA 173 Query: 588 GYLANMGGLAAGADAAYIFEEPFDIRDLQSNVEHLTEKMKTTIQRGLVLRNESCSENYTT 647 G +A GLA GA+ I E +D+ D+ + ++ E+ K + +++ E Sbjct: 174 GDIALWSGLAGGAETILIPEADYDMNDVIARLKRGHERGK---KHSIIIVAEGVGSG--V 228 Query: 648 DFIYQLYSEEGKGVFDCRKNVLGHMQQGGAPSPFDRNFGTKISARAME-WITAKLKEARG 706 DF Q+ G F+ R VLGH+Q+GG+P+ FDR +++ ARA+E + K G Sbjct: 229 DFGRQIQEATG---FETRVTVLGHVQRGGSPTAFDRVLASRLGARAVELLLEGKGGRCVG 285 Query: 707 -RGKKFTTDDSICVLGISKRNVIFQPVAELKKQ 738 + + D L ++ I Q + L K+ Sbjct: 286 IQNNQLVDHDIAEALA--NKHTIDQRMYALSKE 316 >5XZ7-A nrPDB Length = 330 Score = 358 bits (919), Expect = 4e-99, Method: Composition-based stats. Identities = 136/329 (41%), Positives = 191/329 (58%), Gaps = 36/329 (10%) Query: 25 KAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGGSNIAEADWESVSS 84 K I VLTSGGD+ GMNAAVRAVVR IY +VY +Y GYQG+++ +I + + SV Sbjct: 2 KKIAVLTSGGDSPGMNAAVRAVVRTAIYNEIEVYGVYHGYQGLLN--DDIHKLELGSVGD 59 Query: 85 ILQVGGTIIGSARCQAFRTREGRLKAACNLLQRGITNLCVIGGDGSLTGANLFRKEWSGL 144 +Q GGT + SARC F+ +E R A NL +RGI L VIGGDGS GA +E Sbjct: 60 TIQRGGTFLYSARCPEFKEQEVRKVAIENLRKRGIEGLVVIGGDGSYRGAQRISEEC--- 116 Query: 145 LEELARNGQIDKEAVQKYAYLNVVGMVGSIDNDFCGTDMTIGTDSALHRIIEVVDAIMTT 204 + +G+ G+IDND GTD TIG D+AL+ II +VD I T Sbjct: 117 ------------------KEIQTIGIPGTIDNDINGTDFTIGFDTALNTIIGLVDKIRDT 158 Query: 205 AQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEEGWEEQMCVKLSENRARKK 264 A SH RTF++E MGR CG LAL + L+ GA+ + +PE + +++ K+ + R K Sbjct: 159 ASSHARTFIIEAMGRDCGDLALWAGLSVGAETIVVPEVKTDI---KEIADKIEQGIKRGK 215 Query: 265 RLNIIIVAEGAIDTQNKPITSEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILASR 324 + +I++VAEG +T++ ++ + + D RV++LGHVQRGG+P+ DR+LASR Sbjct: 216 KHSIVLVAEGC-------MTAQDCQKELSQYINVDNRVSVLGHVQRGGSPTGADRVLASR 268 Query: 325 MGVEAVIALLEATPDTPACVVSLNGNHAV 353 +G AV L++ A V + N V Sbjct: 269 LGGYAVDLLMQGE---TAKGVGIKNNKIV 294 Score = 331 bits (848), Expect = 9e-91, Method: Composition-based stats. Identities = 96/305 (31%), Positives = 150/305 (49%), Gaps = 18/305 (5%) Query: 411 CNVAVINVGAPAAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWT 470 +AV+ G + GMNAAVR+ VR I + + +Y G+ G I ++ VG Sbjct: 2 KKIAVLTSGGDSPGMNAAVRAVVRTAIYNEIEVYGVYHGYQGLLNDDIHKLELGSVGDTI 61 Query: 471 GQGGSILGTKRVLPGKYLE---EIATQMRTHSINALLIIGGFEAYLGLLELSAAREKHEE 527 +GG+ L + R K E +R I L++IGG +Y G R E Sbjct: 62 QRGGTFLYSARCPEFKEQEVRKVAIENLRKRGIEGLVVIGGDGSYRGA-----QRISEEC 116 Query: 528 FCVPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRIKQSASGTKRRVFIIETMGGYC 587 + + +P T+ N++ G+DF+IG DTALNTI D+I+ +AS + R FIIE MG C Sbjct: 117 KEIQTIGIPGTIDNDINGTDFTIGFDTALNTIIGLVDKIRDTAS-SHARTFIIEAMGRDC 175 Query: 588 GYLANMGGLAAGADAAYIFEEPFDIRDLQSNVEHLTEKMKTTIQRGLVLRNESCSENYTT 647 G LA GL+ GA+ + E DI+++ +E ++ K + +VL E C Sbjct: 176 GDLALWAGLSVGAETIVVPEVKTDIKEIADKIEQGIKRGK---KHSIVLVAEGCMTAQDC 232 Query: 648 DFIYQLYSEEGKGVFDCRKNVLGHMQQGGAPSPFDRNFGTKISARAMEWITAKLKEARGR 707 Y D R +VLGH+Q+GG+P+ DR +++ A++ + + + A+G Sbjct: 233 QKELSQYIN-----VDNRVSVLGHVQRGGSPTGADRVLASRLGGYAVDLLM-QGETAKGV 286 Query: 708 GKKFT 712 G K Sbjct: 287 GIKNN 291 >1PFK-A nrPDB Length = 320 Score = 351 bits (900), Expect = 8e-97, Method: Composition-based stats. Identities = 127/341 (37%), Positives = 180/341 (52%), Gaps = 38/341 (11%) Query: 25 KAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGGSNIAEADWESVSS 84 K IGVLTSGGDA GMNAA+R VVR + G +V IY+GY G+ + + + D SVS Sbjct: 3 KKIGVLTSGGDAPGMNAAIRGVVRSALTEGLEVMGIYDGYLGLYE--DRMVQLDRYSVSD 60 Query: 85 ILQVGGTIIGSARCQAFRTREGRLKAACNLLQRGITNLCVIGGDGSLTGANLFRKEWSGL 144 ++ GGT +GSAR FR R A NL +RGI L VIGGDGS GA + Sbjct: 61 MINRGGTFLGSARFPEFRDENIRAVAIENLKKRGIDALVVIGGDGSYMGAMRLTE----- 115 Query: 145 LEELARNGQIDKEAVQKYAYLNVVGMVGSIDNDFCGTDMTIGTDSALHRIIEVVDAIMTT 204 +G+ G+IDND GTD TIG +AL ++E +D + T Sbjct: 116 ------------------MGFPCIGLPGTIDNDIKGTDYTIGFFTALSTVVEAIDRLRDT 157 Query: 205 AQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEEGWEEQMCVKLSENRARKK 264 + SHQR V+EVMGR+CG L L +A+A G ++V +PE E E + ++ A+ K Sbjct: 158 SSSHQRISVVEVMGRYCGDLTLAAAIAGGCEFVVVPEV---EFSREDLVNEIKAGIAKGK 214 Query: 265 RLNIIIVAEGAIDTQNKPITSEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILASR 324 + I+ + E D ++ + + G +TR T+LGH+QRGG+P +DRILASR Sbjct: 215 KHAIVAITEHMCDVD-------ELAHFIEKETGRETRATVLGHIQRGGSPVPYDRILASR 267 Query: 325 MGVEAVIALLEATPDTPACVVSLNGNHAVRLPLMECVQMTQ 365 MG A+ LL V + V +++ ++ + Sbjct: 268 MGAYAIDLLLAGYGGR---CVGIQNEQLVHHDIIDAIENMK 305 Score = 314 bits (805), Expect = 7e-86, Method: Composition-based stats. Identities = 89/320 (27%), Positives = 162/320 (50%), Gaps = 21/320 (6%) Query: 411 CNVAVINVGAPAAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWT 470 + V+ G A GMNAA+R VR + +G ++ IYDG+ G + ++ ++ V Sbjct: 3 KKIGVLTSGGDAPGMNAAIRGVVRSALTEGLEVMGIYDGYLGLYEDRMVQLDRYSVSDMI 62 Query: 471 GQGGSILGTKRVLPG--KYLEEIA-TQMRTHSINALLIIGGFEAYLGLLELSAAREKHEE 527 +GG+ LG+ R + + +A ++ I+AL++IGG +Y+G + L+ E Sbjct: 63 NRGGTFLGSARFPEFRDENIRAVAIENLKKRGIDALVVIGGDGSYMGAMRLT-------E 115 Query: 528 FCVPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRIKQSASGTKRRVFIIETMGGYC 587 P + +P T+ N++ G+D++IG TAL+T+ + DR++ + S + +R+ ++E MG YC Sbjct: 116 MGFPCIGLPGTIDNDIKGTDYTIGFFTALSTVVEAIDRLRDT-SSSHQRISVVEVMGRYC 174 Query: 588 GYLANMGGLAAGADAAYIFEEPFDIRDLQSNVEHLTEKMKTTIQRGLVLRNESCSENYTT 647 G L +A G + + E F DL + ++ K K + + C + Sbjct: 175 GDLTLAAAIAGGCEFVVVPEVEFSREDLVNEIKAGIAKGKK--HAIVAITEHMCDVDELA 232 Query: 648 DFIYQLYSEEGKGVFDCRKNVLGHMQQGGAPSPFDRNFGTKISARAMEWITAKLKEA--R 705 FI + E G+ + R VLGH+Q+GG+P P+DR +++ A A++ + A Sbjct: 233 HFIEK---ETGR---ETRATVLGHIQRGGSPVPYDRILASRMGAYAIDLLLAGYGGRCVG 286 Query: 706 GRGKKFTTDDSICVLGISKR 725 + ++ D I + KR Sbjct: 287 IQNEQLVHHDIIDAIENMKR 306 >1ZXX-A nrPDB Length = 319 Score = 347 bits (891), Expect = 1e-95, Method: Composition-based stats. Identities = 125/341 (36%), Positives = 182/341 (53%), Gaps = 38/341 (11%) Query: 25 KAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGGSNIAEADWESVSS 84 K IG+LTSGGDA GMNAAVRAV R+ I G +V+ I G+ G+V G I + E V+ Sbjct: 2 KRIGILTSGGDAPGMNAAVRAVTRVAIANGLEVFGIRYGFAGLVAGD--IFPLESEDVAH 59 Query: 85 ILQVGGTIIGSARCQAFRTREGRLKAACNLLQRGITNLCVIGGDGSLTGANLFRKEWSGL 144 ++ V GT + SAR F EG+L L + GI + VIGGDGS GA Sbjct: 60 LINVSGTFLYSARYPEFAEEEGQLAGIEQLKKHGIDAVVVIGGDGSYHGAL--------- 110 Query: 145 LEELARNGQIDKEAVQKYAYLNVVGMVGSIDNDFCGTDMTIGTDSALHRIIEVVDAIMTT 204 +L R+G N +G+ G+IDND TD TIG D+A ++ +D I T Sbjct: 111 --QLTRHG------------FNSIGLPGTIDNDIPYTDATIGYDTACMTAMDAIDKIRDT 156 Query: 205 AQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEEGWEEQMCVKLSENRARKK 264 A SH R F++ VMGR+CG +A+ +ACGAD + +PE P + E++ +L + + K Sbjct: 157 ASSHHRVFIVNVMGRNCGDIAMRVGVACGADAIVIPERPYD---VEEIANRLKQAQESGK 213 Query: 265 RLNIIIVAEGAIDTQNKPITSEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILASR 324 +++VAEG +T+++ + +D R +LGH+QRGGTP+ DR+LAS+ Sbjct: 214 DHGLVVVAEGV-------MTADQFMAELKKYGDFDVRANVLGHMQRGGTPTVSDRVLASK 266 Query: 325 MGVEAVIALLEATPDTPACVVSLNGNHAVRLPLMECVQMTQ 365 +G EAV LLE V + +++ + Sbjct: 267 LGSEAVHLLLEGKGGLA---VGIENGKVTSHDILDLFDESH 304 Score = 315 bits (808), Expect = 4e-86, Method: Composition-based stats. Identities = 105/334 (31%), Positives = 159/334 (47%), Gaps = 35/334 (10%) Query: 411 CNVAVINVGAPAAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWT 470 + ++ G A GMNAAVR+ RV IA+G + I GF G G I + DV Sbjct: 2 KRIGILTSGGDAPGMNAAVRAVTRVAIANGLEVFGIRYGFAGLVAGDIFPLESEDVAHLI 61 Query: 471 GQGGSILGTKRVLPGKYLE---EIATQMRTHSINALLIIGGFEAYLGLLELSAAREKHEE 527 G+ L + R E Q++ H I+A+++IGG +Y G L+L+ Sbjct: 62 NVSGTFLYSARYPEFAEEEGQLAGIEQLKKHGIDAVVVIGGDGSYHGALQLTR------- 114 Query: 528 FCVPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRIKQSASGTKRRVFIIETMGGYC 587 + +P T+ N++P +D +IG DTA T D D+I+ +AS + RVFI+ MG C Sbjct: 115 HGFNSIGLPGTIDNDIPYTDATIGYDTACMTAMDAIDKIRDTAS-SHHRVFIVNVMGRNC 173 Query: 588 GYLANMGGLAAGADAAYIFEEPFDIRDLQSNVEHLTEKMKTTIQRGLVLRNESCSENYTT 647 G +A G+A GADA I E P+D+ ++ + ++ E K GLV+ E Sbjct: 174 GDIAMRVGVACGADAIVIPERPYDVEEIANRLKQAQESGK---DHGLVVVAEGVMTA--- 227 Query: 648 DFIYQLYSEEGK-GVFDCRKNVLGHMQQGGAPSPFDRNFGTKISARAMEWITAKLKEARG 706 Q +E K G FD R NVLGHMQ+GG P+ DR +K+ + A+ + E +G Sbjct: 228 ---DQFMAELKKYGDFDVRANVLGHMQRGGTPTVSDRVLASKLGSEAVHLL----LEGKG 280 Query: 707 RGKKFTTDDSICVLGISKRNVIFQPVAELKKQTD 740 +GI V + +L ++ Sbjct: 281 ----------GLAVGIENGKVTSHDILDLFDESH 304 >2HIG-A nrPDB Length = 487 Score = 296 bits (758), Expect = 2e-80, Method: Composition-based stats. Identities = 99/383 (25%), Positives = 169/383 (44%), Gaps = 61/383 (15%) Query: 19 HLSGAGKAIGVLTSGGDAQGMNAAVRAVVRMGI--YVGAKVYFIYEGYQGMVDGGSNIA- 75 H + IG++T GG G+N +R++ GI Y +V GY G+ GS A Sbjct: 92 HFNPTETTIGIVTCGGICPGLNDVIRSITLTGINVYNVKRVIGFRFGYWGLSKKGSQTAI 151 Query: 76 EADWESVSSILQVGGTIIGSARCQAFRTREGRLKAACNLLQR-GITNLCVIGGDGSLTGA 134 E V++I GGTI+GS+R K + L+R G+ L +GGDG+ GA Sbjct: 152 ELHRGRVTNIHHYGGTILGSSRGPQ------DPKEMVDTLERLGVNILFTVGGDGTQRGA 205 Query: 135 NLFRKEWSGLLEELARNGQIDKEAVQKYAYLNVVGMVGSIDNDFCGTDMTIGTDSALHRI 194 + I +EA ++ ++V G+ +IDND + T G +A+ + Sbjct: 206 LV-----------------ISQEAKRRGVDISVFGVPKTIDNDLSFSHRTFGFQTAVEKA 248 Query: 195 IEVVDAIMTTAQSHQRTF-VLEVMGRHCGYL-ALVSALACGADWVFLPESPPEEGWEEQM 252 ++ + A A S V+++MGR G++ A + + A+ +PE+P EQ Sbjct: 249 VQAIRAAYAEAVSANYGVGVVKLMGRDSGFIAAQAAVASAQANICLVPENP----ISEQE 304 Query: 253 CVKLSENRARKKRLNIIIVAE----------GAIDTQNKP-------ITSEKIKELVVTQ 295 + L E R R +IIVAE G D I +EK+K + Sbjct: 305 VMSLLERRFCHSRSCVIIVAEGFGQDWGRGSGGYDASGNKKLIDIGVILTEKVKAFLKAN 364 Query: 296 LGY--DTRVTIL--GHVQRGGTPSAFDRILASRMGVEAVIALLEATPDTPACVVSLNGNH 351 D+ V + ++ R PSA D + + + A +A+ EA C++++ N+ Sbjct: 365 KSRYPDSTVKYIDPSYMIRACPPSANDALFCATL---ATLAVHEAMAGATGCIIAMRHNN 421 Query: 352 AVRLPLMECVQMTQDVQKAMDER 374 + +P +++ V++ +D R Sbjct: 422 YILVP----IKVATSVRRVLDLR 440 Score = 120 bits (301), Expect = 2e-27, Method: Composition-based stats. Identities = 65/380 (17%), Positives = 130/380 (34%), Gaps = 54/380 (14%) Query: 409 TNCNVAVINVGAPAAGMNAAVRSAVRVGI--ADGHRMLAIYDGFDGFAK---GQIKEIGW 463 T + ++ G G+N +RS GI + R++ G+ G +K E+ Sbjct: 96 TETTIGIVTCGGICPGLNDVIRSITLTGINVYNVKRVIGFRFGYWGLSKKGSQTAIELHR 155 Query: 464 TDVGGWTGQGGSILGTKRVLPGKYLEEIATQMRTHSINALLIIGGFEAYLGLLELSAARE 523 V GG+ILG+ R + +E+ + +N L +GG G L +S + Sbjct: 156 GRVTNIHHYGGTILGSSRGP--QDPKEMVDTLERLGVNILFTVGGDGTQRGALVISQEAK 213 Query: 524 KHEEFCVPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRIKQSASGTKRRVFIIETM 583 + + + VP T+ N++ S + G TA+ A V +++ M Sbjct: 214 RRGV-DISVFGVPKTIDNDLSFSHRTFGFQTAVEKAVQAIRAAYAEAVSANYGVGVVKLM 272 Query: 584 GGYCGYLANMGGLAAGADAA-YIFEEPFDIRDLQSNVEHLTEKMKTTIQRGLVLRNESCS 642 G G++A +A+ + E P +++ L E+ + +++ E Sbjct: 273 GRDSGFIAAQAAVASAQANICLVPENPISEQEVM----SLLERRFCHSRSCVIIVAEGFG 328 Query: 643 ENY---------------------TTDFIYQLYSEEGKGVFDCRKNV--LGHMQQGGAPS 679 +++ T+ + D +M + PS Sbjct: 329 QDWGRGSGGYDASGNKKLIDIGVILTEKVKAFLKANKSRYPDSTVKYIDPSYMIRACPPS 388 Query: 680 PFDRNFGTKISARAMEWITAKLKEARGRGKKFTTDDSICVLGISKRNVIFQPVAELKKQT 739 D F ++ A+ A + C++ + N I P+ T Sbjct: 389 ANDALFCATLATLAVHEAMAGA--------------TGCIIAMRHNNYILVPIK---VAT 431 Query: 740 DFEHRIP-KEQWWLKLRPLM 758 + + Q W ++R + Sbjct: 432 SVRRVLDLRGQLWRQVREIT 451 >3K2Q-A nrPDB Length = 420 Score = 218 bits (555), Expect = 8e-57, Method: Composition-based stats. Identities = 69/318 (21%), Positives = 120/318 (37%), Gaps = 39/318 (12%) Query: 418 VGAPAAGMNAAVRSAVRVGIADGH---RMLAIYDGFDGFAKGQIKEIGWTD---VGGWTG 471 G A +NA+ ++ ++ A +G G K ++ + + Sbjct: 11 SGGVTAVINASACGVIQTARKHPDQIGKVYAGRNGIIGALKEELIDTSLESDDAIQALIH 70 Query: 472 QGGSILGTKR------VLPGKYLEEIATQMRTHSINALLIIGGFEAYLGLLELSAAREKH 525 G G+ R + E + R H I GG ++ ++S ++ Sbjct: 71 TPGGAFGSCRYKLKNISENQREYERLIEVFRAHDIGYFFYNGGGDSQDTAYKVSQLADRM 130 Query: 526 EEFCVPMVMVPATVSNNVPGSDF-----SIGADTALNTITDTCDRIKQSASGTKRRVFII 580 + + + VP TV N++P +D S+ A +T+ + D +S T +VFI+ Sbjct: 131 G-YPITCIGVPKTVDNDLPFTDCCPGFGSVAKYIATSTLEASLD--IKSMCETSTKVFIL 187 Query: 581 ETMGGYCGYLANMGGLAAGADAAYIFEEPFDI--RDLQSNVEHLTEKMKTTIQ-RGLVLR 637 E MG + G++A GGLA ++ E P I ++ N E E++ ++ G + Sbjct: 188 EVMGRHAGWIAAAGGLAGQSEG----EPPHVILFPEIPFNREKFLERVDQCVRDYGYCVV 243 Query: 638 NESCSENYTTDFIYQLYSEEGKGVFDC-RKNVLGHMQQGGAPSPFDRNFGTKISARAMEW 696 S Y E+G+ V D K+ GH Q GG +P N + W Sbjct: 244 VASEGAQY----------EDGRFVADAGAKDAFGHTQLGGV-APALANMVKQALGHKYHW 292 Query: 697 ITAKLKEARGRGKKFTTD 714 A + R TD Sbjct: 293 AVADYLQRAARHIASATD 310 Score = 174 bits (442), Expect = 1e-43, Method: Composition-based stats. Identities = 59/311 (18%), Positives = 108/311 (34%), Gaps = 50/311 (16%) Query: 32 SGGDAQGMNAAVRAVVRMGIYV---GAKVYFIYEGYQGMVDGGSNIAEADWES-VSSILQ 87 SGG +NA+ V++ KVY G G + + + + +++ Sbjct: 11 SGGVTAVINASACGVIQTARKHPDQIGKVYAGRNGIIGALKEELIDTSLESDDAIQALIH 70 Query: 88 VGGTIIGSARCQA---FRTREGRLKAACNLLQRGITNLCVIGGDGSLTGANLFRKEWSGL 144 G GS R + + + I GG S A Sbjct: 71 TPGGAFGSCRYKLKNISENQREYERLIEVFRAHDIGYFFYNGGGDSQDTAY--------- 121 Query: 145 LEELARNGQIDKEAVQKYAYLNVVGMVGSIDNDFCGTDMTIGTDSALHRI----IEVVDA 200 ++ + A + + +G+ ++DND TD G S I +E Sbjct: 122 --------KVSQLADRMGYPITCIGVPKTVDNDLPFTDCCPGFGSVAKYIATSTLEASLD 173 Query: 201 IMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADW-----VFLPESPPEEGWEEQMCVK 255 I + ++ + F+LEVMGRH G++A LA ++ + PE P + + ++ Sbjct: 174 IKSMCETSTKVFILEVMGRHAGWIAAAGGLAGQSEGEPPHVILFPEIP----FNREKFLE 229 Query: 256 LSENRARKKRLNIIIVAEGAIDTQNKPITSEKIKELVVTQLGYDTRVTILGHVQRGGTPS 315 + R +++ +EGA + + K+ GH Q GG Sbjct: 230 RVDQCVRDYGYCVVVASEGAQYEDGRFVADAGAKDA-------------FGHTQLGGVAP 276 Query: 316 AFDRILASRMG 326 A ++ +G Sbjct: 277 ALANMVKQALG 287 >1KZH-A nrPDB Length = 555 Score = 214 bits (545), Expect = 1e-55, Method: Composition-based stats. Identities = 58/261 (22%), Positives = 105/261 (40%), Gaps = 29/261 (11%) Query: 27 IGVLTSGGDAQGMNAAVRAVVRM--GIYVGAKVYFIYEGYQGMVDGGSNIAEADWESVSS 84 IG++ SGG A G + + V +K++ G G+++ E ++S Sbjct: 75 IGIILSGGPAPGGHNVISGVFDAIKKFNPNSKLFGFKGGPLGLLENDK--IELTESLINS 132 Query: 85 ILQVGGTIIGSARCQAFRTREGRLKAACNLLQRGITNLCVIGGDGSLTGANLFRKEWSGL 144 GG I S+ T E KA + + + +IGGD S T A + L Sbjct: 133 YRNTGGFDIVSSGRTKIETEEHYNKALFVAKENNLNAIIIIGGDDSNTNAAI-------L 185 Query: 145 LEELARNGQIDKEAVQKYAYLNVVGMVGSIDNDFCG--TDMTIGTDSALHRIIEVVDAIM 202 E +NG+ + V+G+ +ID D +++ G DSA E++ + Sbjct: 186 AEYFKKNGE----------NIQVIGVPKTIDADLRNDHIEISFGFDSATKIYSELIGNLC 235 Query: 203 TTAQSHQRTF-VLEVMGRHCGYLALVSALACGADWVFLPE-----SPPEEGWEEQMCVKL 256 A S ++ + +++MGR ++AL AL + + E ++M + Sbjct: 236 RDAMSTKKYWHFVKLMGRSASHVALECALKTHPNICIVSEEVLAKKKTLSEIIDEMVSVI 295 Query: 257 SENRARKKRLNIIIVAEGAID 277 + ++IV EG I+ Sbjct: 296 LKRSLNGDNFGVVIVPEGLIE 316 Score = 89.4 bits (220), Expect = 6e-18, Method: Composition-based stats. Identities = 41/244 (16%), Positives = 95/244 (38%), Gaps = 13/244 (5%) Query: 409 TNCNVAVINVGAPAAGMNAAVRSA--VRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDV 466 N+ +I G PA G + + ++ G G + E+ + + Sbjct: 71 KALNIGIILSGGPAPGGHNVISGVFDAIKKFNPNSKLFGFKGGPLGLLENDKIELTESLI 130 Query: 467 GGWTGQGGSIL---GTKRVLPGKYLEEIATQMRTHSINALLIIGGFEAYLGLLELSAARE 523 + GG + G ++ ++ + + +++NA++IIGG ++ L+ + Sbjct: 131 NSYRNTGGFDIVSSGRTKIETEEHYNKALFVAKENNLNAIIIIGGDDSNTNAAILAEYFK 190 Query: 524 KHEEFCVPMVMVPATVSNNVPGS--DFSIGADTALNTITDTCDRIKQSASGTKRRVFIIE 581 K+ E + ++ VP T+ ++ + S G D+A ++ + + A TK+ ++ Sbjct: 191 KNGE-NIQVIGVPKTIDADLRNDHIEISFGFDSATKIYSELIGNLCRDAMSTKKYWHFVK 249 Query: 582 TMGGYCGYLANMGGLAAGADAAYIFEEPFDIRDLQSNV-----EHLTEKMKTTIQRGLVL 636 MG ++A L + + EE + S + + ++ G+V+ Sbjct: 250 LMGRSASHVALECALKTHPNICIVSEEVLAKKKTLSEIIDEMVSVILKRSLNGDNFGVVI 309 Query: 637 RNES 640 E Sbjct: 310 VPEG 313 Score = 31.2 bits (69), Expect = 1.7, Method: Composition-based stats. Identities = 14/63 (22%), Positives = 25/63 (39%) Query: 286 EKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEATPDTPACVV 345 +K+ + + G+ R PS FD +G AV+ +L +C+ Sbjct: 407 NDMKKRGEYKGSFTPVDHFFGYEGRSAFPSNFDSDYCYSLGYNAVVLILNGLTGYMSCIK 466 Query: 346 SLN 348 +LN Sbjct: 467 NLN 469 >3HNO-A nrPDB Length = 419 Score = 184 bits (466), Expect = 2e-46, Method: Composition-based stats. Identities = 74/401 (18%), Positives = 138/401 (34%), Gaps = 75/401 (18%) Query: 418 VGAPAAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSIL 477 G A +NA+ + ++ IY G +G G + E D+ + + + Sbjct: 11 SGGVTAVINASAAGVIEAARKQSGKIGRIYAGRNGII-GALTE----DLIDTGQESDAAI 65 Query: 478 GTKRVLPG-----------------KYLEEIATQMRTHSINALLIIGGFEAYLGLLELSA 520 R P + E + + H I GG ++ L++S Sbjct: 66 SALRYTPSGAFGSCRYKLKSLEQNRREYERLIEVFKAHDIGYFFYNGGGDSADTCLKVSQ 125 Query: 521 AREKHEEFCVPMVMVPATVSNNVPGSDF-----SIGADTALNTITDTCDRIKQSASGTKR 575 + + + VP TV N++P +D S+ A++T+ + D SA+ TK Sbjct: 126 LSGTLG-YPIQAIHVPKTVDNDLPITDCCPGFGSVAKYIAVSTLEASFDVASMSATSTK- 183 Query: 576 RVFIIETMGGYCGYLANMGGLAAGAD-----AAYIFEEPFDIRDLQSNVEHLTEKMKTTI 630 VF++E MG + G++A GGLA+ + E FD + + V+ +K Sbjct: 184 -VFVLEVMGRHAGWIAAAGGLASSPEREIPVVILFPEISFDKQKFLAKVDSCVKKFGYCS 242 Query: 631 QRGLVLRNESCSENYTTDFIYQLYSEEGKGVFDCRK-NVLGHMQQGGAPSPFDRNFGTKI 689 V+ +E + ++GK + D + GH Q GG +P + + Sbjct: 243 ----VVVSEG------------VKGDDGKFLSDQGVRDAFGHAQLGGV-APVVASMVKEG 285 Query: 690 SARAMEWITAKLKEARGRGKKFTTD--------DSICVLGISKRNVIFQPV--------- 732 W A + R TD + + N + + Sbjct: 286 LGLKYHWGVADYLQRAARHIASKTDVEQAYAMGQAAVEFAVQGHNSVMPTIERISARPYQ 345 Query: 733 -----AELKKQTDFEHRIPKEQWWLKLRPLMKILAKYKASY 768 A+L + + E +P+ + + +Y A Sbjct: 346 WKVGMAQLSQVANVEKMMPENFITEDGFGITDLCREYLAPL 386 Score = 158 bits (400), Expect = 7e-39, Method: Composition-based stats. Identities = 57/313 (18%), Positives = 113/313 (36%), Gaps = 50/313 (15%) Query: 32 SGGDAQGMNAAVRAVVRMGIYVGAKVYFIYEGYQG----MVDGGSNIAEADWESVSSILQ 87 SGG +NA+ V+ K+ IY G G + + + + ++S++ Sbjct: 11 SGGVTAVINASAAGVIEAARKQSGKIGRIYAGRNGIIGALTEDLIDTGQESDAAISALRY 70 Query: 88 VGGTIIGSARCQAFRTREGRL---KAACNLLQRGITNLCVIGGDGSLTGANLFRKEWSGL 144 GS R + + R + I GG S A+ Sbjct: 71 TPSGAFGSCRYKLKSLEQNRREYERLIEVFKAHDIGYFFYNGGGDS---ADTCL------ 121 Query: 145 LEELARNGQIDKEAVQKYAYLNVVGMVGSIDNDFCGTDMTIGTDSALHRI----IEVVDA 200 ++ + + + + + ++DND TD G S I +E Sbjct: 122 --------KVSQLSGTLGYPIQAIHVPKTVDNDLPITDCCPGFGSVAKYIAVSTLEASFD 173 Query: 201 IMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADW-----VFLPESPPEEGWEEQMCVK 255 + + + + + FVLEVMGRH G++A LA + + PE +++Q + Sbjct: 174 VASMSATSTKVFVLEVMGRHAGWIAAAGGLASSPEREIPVVILFPEI----SFDKQKFLA 229 Query: 256 LSENRARKKRLNIIIVAEGAIDTQNKPITSEKIKELVVTQLGYDTRVTILGHVQRGGTPS 315 ++ +K ++V+EG K ++ + +++ GH Q GG Sbjct: 230 KVDSCVKKFGYCSVVVSEGVKGDDGKFLSDQGVRDA-------------FGHAQLGGVAP 276 Query: 316 AFDRILASRMGVE 328 ++ +G++ Sbjct: 277 VVASMVKEGLGLK 289 >5FHY-A nrPDB Length = 346 Score = 35.1 bits (79), Expect = 0.13, Method: Composition-based stats. Identities = 31/144 (21%), Positives = 56/144 (38%), Gaps = 11/144 (7%) Query: 275 AIDTQNKPIT------SEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDR--ILASRMG 326 A+ KPIT +K+ V + +T + Q T D+ + + +G Sbjct: 202 AVTEAGKPITLTVSRDDAGVKDNVKKFVEAYNTLTKFINEQTVVTKVGEDKNPVTGALLG 261 Query: 327 VEAVIALLEATPDTPACVVSLNGNHAVRLPLMECVQMTQDVQKAMDERRFQDAVRLRGRS 386 +V AL+ + +++ N N +VR + T+D +DE++ A+ Sbjct: 262 DASVRALVNTM---RSELIASNENGSVRNLAALGITTTKDGTLEIDEKKLDKAISADFEG 318 Query: 387 FAGNLNTYKRLAIKLPDDQIPKTN 410 A LA +L D P T+ Sbjct: 319 VASYFTGDTGLAKRLGDKMKPYTD 342 >4MCA-A nrPDB Length = 367 Score = 34.3 bits (77), Expect = 0.19, Method: Composition-based stats. Identities = 11/65 (16%), Positives = 31/65 (47%), Gaps = 6/65 (9%) Query: 486 KYLEEIATQMRTHSINALLIIGGFEAYLGLLELSAAREKHEEFCVPMVMVPATVSNNVPG 545 K ++ + +++ H ++ +GG + ++ ++ +P+V++P S + P Sbjct: 71 KEIDRLGRELKAHGCRGVIGVGGGKTLDTAKAIAHYQQ------LPVVLIPTIASTDAPT 124 Query: 546 SDFSI 550 S S+ Sbjct: 125 SALSV 129 >3KNZ-A nrPDB Length = 366 Score = 32.8 bits (73), Expect = 0.58, Method: Composition-based stats. Identities = 21/72 (29%), Positives = 34/72 (47%), Gaps = 3/72 (4%) Query: 102 RTREGRLKAACNLLQRGITNLCVIGGDGSLTGAN---LFRKEWSGLLEELARNGQIDKEA 158 +TRE +AA L +RG+T + + G S GA F + W L ++ +D E Sbjct: 33 QTREDLWRAAQALTERGVTRIILTGSGTSYHGALTARTFMQRWCALPVDVCWPFMLDDET 92 Query: 159 VQKYAYLNVVGM 170 + + VVG+ Sbjct: 93 LARSGKALVVGI 104 >4RGQ-A nrPDB Length = 368 Score = 32.0 bits (71), Expect = 0.93, Method: Composition-based stats. Identities = 11/59 (18%), Positives = 27/59 (45%), Gaps = 7/59 (11%) Query: 485 GKYLEEIATQMRTH-SINALLIIGGFEAYLGLLELSAAREKHEEFCVPMVMVPATVSNN 542 + L + +++ + + + ++ IGG + L+ + +P + VP T SN+ Sbjct: 86 DEILNNLEIELKKYTAYDCVIGIGGGRSIDTGKYLAY------KLGIPFISVPTTASND 138 >5LX9-A nrPDB Length = 307 Score = 32.0 bits (71), Expect = 0.96, Method: Composition-based stats. Identities = 16/80 (20%), Positives = 29/80 (36%), Gaps = 3/80 (3%) Query: 444 LAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGTKRVLPGKYLEEIATQMRTHS-INA 502 I +GF I +IGW + G+ L R+ + + +H + Sbjct: 217 YVISEGF--LKAATIGQIGWLMLMASLYITGAALYAARIPERFFPGKCDIWFHSHQLFHI 274 Query: 503 LLIIGGFEAYLGLLELSAAR 522 ++ G F + G+ L R Sbjct: 275 FVVAGAFVHFHGVSNLQEFR 294 >4RFL-A nrPDB Length = 371 Score = 31.6 bits (70), Expect = 1.2, Method: Composition-based stats. Identities = 11/59 (18%), Positives = 27/59 (45%), Gaps = 7/59 (11%) Query: 485 GKYLEEIATQMRTH-SINALLIIGGFEAYLGLLELSAAREKHEEFCVPMVMVPATVSNN 542 + L + +++ + + + ++ IGG + L+ + +P + VP T SN+ Sbjct: 89 DEILNNLEIELKKYTAYDCVIGIGGGRSIDTGKYLAY------KLGIPFISVPTTASND 141 >6B9O-A nrPDB Length = 981 Score = 30.1 bits (66), Expect = 3.5, Method: Composition-based stats. Identities = 18/116 (15%), Positives = 38/116 (32%), Gaps = 6/116 (5%) Query: 536 PATVSNNVPGSD----FSIGADTALNTITDTCDRIKQSASGTKRRVFII--ETMGGYCGY 589 P + + P +D + G T+ + + D + T++ F ++ + Sbjct: 316 PLKIDDYFPYADGRNAYWTGFYTSRSALKDYVRMLSGYYLATRQLGFFAGKKSTKYHAFD 375 Query: 590 LANMGGLAAGADAAYIFEEPFDIRDLQSNVEHLTEKMKTTIQRGLVLRNESCSENY 645 LA+ G+A DA + D + K + + L S + Sbjct: 376 LADALGIAQHHDAVSGTAKQHTTNDYAKRLAIGASKAEAVVSSSLACLTSKQSADQ 431 >4BHD-A nrPDB Length = 428 Score = 30.1 bits (66), Expect = 4.1, Method: Composition-based stats. Identities = 14/45 (31%), Positives = 20/45 (44%), Gaps = 4/45 (8%) Query: 461 IGWTDVGGWTGQGGSILGTKRVLP----GKYLEEIATQMRTHSIN 501 + W DV G LGT+ K +EEIA M+ +I+ Sbjct: 347 LPWDDVNNSDNPSGIRLGTQECTRLGMKEKEMEEIAEFMKRIAID 391 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.313 0.130 0.330 Lambda K H 0.267 0.0397 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 27,509,901 Number of Sequences: 36641 Number of extensions: 1068796 Number of successful extensions: 3606 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 31 Number of HSP's successfully gapped in prelim test: 23 Number of HSP's that attempted gapping in prelim test: 3249 Number of HSP's gapped (non-prelim): 82 length of query: 784 length of database: 10,336,785 effective HSP length: 105 effective length of query: 679 effective length of database: 6,489,480 effective search space: 4406356920 effective search space used: 4406356920 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.5 bits) S2: 63 (28.9 bits)