BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q01574 (713 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 1RY2-A nrPDB 1333 0.0 5U29-A nrPDB 706 0.0 5JRH-A nrPDB 585 e-167 4WD1-A nrPDB 203 2e-52 3ETC-A nrPDB 171 1e-42 3GPC-A nrPDB 164 1e-40 4WV3-A nrPDB 137 1e-32 5IE2-A nrPDB 127 2e-29 3A9U-A nrPDB 125 5e-29 4EAT-A nrPDB 123 3e-28 4FUQ-A nrPDB 121 1e-27 5BSW-A nrPDB 116 4e-26 3R44-A nrPDB 115 1e-25 3DLP-X nrPDB 112 6e-25 5BUS-A nrPDB 109 4e-24 2V7B-A nrPDB 108 6e-24 3TSY-A nrPDB 103 3e-22 4GR5-A nrPDB 100 3e-21 4M46-A nrPDB 89 5e-18 5DWV-A nrPDB 89 8e-18 3O84-A nrPDB 87 3e-17 3RG2-A nrPDB 84 2e-16 3IVR-A nrPDB 82 1e-15 2D1S-A nrPDB 76 6e-14 1MDF-A nrPDB 75 1e-13 3IPL-A nrPDB 72 7e-13 5WMM-A nrPDB 69 8e-12 1V25-A nrPDB 58 1e-08 4GR4-A nrPDB 58 2e-08 4LGC-A nrPDB 52 1e-06 3L8C-A nrPDB 50 4e-06 3LNV-A nrPDB 49 9e-06 5ES8-A nrPDB 43 4e-04 5ES6-A nrPDB 43 6e-04 3E7W-A nrPDB 42 0.001 4R0M-B nrPDB 41 0.002 5JNF-C nrPDB 41 0.002 3E53-A nrPDB 39 0.007 3FCE-A nrPDB 39 0.008 4RVO-A nrPDB 39 0.011 2Y4O-A nrPDB 35 0.16 6NJ0-A nrPDB 32 1.1 5NPY-A nrPDB 32 1.4 3PBK-A nrPDB 31 1.5 3K9T-A nrPDB 31 2.2 6FSZ-KK nrPDB 30 3.1 5ACA-1 nrPDB 30 3.6 2RAG-A nrPDB 30 3.8 >1RY2-A nrPDB Length = 663 Score = 1333 bits (3450), Expect = 0.0, Method: Compositional matrix adjust. Identities = 642/642 (100%), Positives = 642/642 (100%) Query: 72 GLQDYQRLHKESIEDPAKFFGSKATQFLNWSKPFDKVFIPDPKTGRPSFQNNAWFLNGQL 131 GLQDYQRLHKESIEDPAKFFGSKATQFLNWSKPFDKVFIPDPKTGRPSFQNNAWFLNGQL Sbjct: 22 GLQDYQRLHKESIEDPAKFFGSKATQFLNWSKPFDKVFIPDPKTGRPSFQNNAWFLNGQL 81 Query: 132 NACYNCVDRHALKTPNKKAIIFEGDEPGQGYSITYKELLEEVCQVAQVLTYSMGVRKGDT 191 NACYNCVDRHALKTPNKKAIIFEGDEPGQGYSITYKELLEEVCQVAQVLTYSMGVRKGDT Sbjct: 82 NACYNCVDRHALKTPNKKAIIFEGDEPGQGYSITYKELLEEVCQVAQVLTYSMGVRKGDT 141 Query: 192 VAVYMPMVPEAIITLLAISRIGAIHSVVFAGFSSNSLRDRINDGDSKVVITTDESNRGGK 251 VAVYMPMVPEAIITLLAISRIGAIHSVVFAGFSSNSLRDRINDGDSKVVITTDESNRGGK Sbjct: 142 VAVYMPMVPEAIITLLAISRIGAIHSVVFAGFSSNSLRDRINDGDSKVVITTDESNRGGK 201 Query: 252 VIETKRIVDDALRETPGVRHVLVYRKTNNPSVAFHAPRDLDWATEKKKYKTYYPCTPVDS 311 VIETKRIVDDALRETPGVRHVLVYRKTNNPSVAFHAPRDLDWATEKKKYKTYYPCTPVDS Sbjct: 202 VIETKRIVDDALRETPGVRHVLVYRKTNNPSVAFHAPRDLDWATEKKKYKTYYPCTPVDS 261 Query: 312 EDPLFLLYTSGSTGAPKGVQHSTAGYLLGALLTMRYTFDTHQEDVFFTAGDIGWITGHTY 371 EDPLFLLYTSGSTGAPKGVQHSTAGYLLGALLTMRYTFDTHQEDVFFTAGDIGWITGHTY Sbjct: 262 EDPLFLLYTSGSTGAPKGVQHSTAGYLLGALLTMRYTFDTHQEDVFFTAGDIGWITGHTY 321 Query: 372 VVYGPLLYGCATLVFEGTPAYPNYSRYWDIIDEHKVTQFYVAPTALRLLKRAGDSYIENH 431 VVYGPLLYGCATLVFEGTPAYPNYSRYWDIIDEHKVTQFYVAPTALRLLKRAGDSYIENH Sbjct: 322 VVYGPLLYGCATLVFEGTPAYPNYSRYWDIIDEHKVTQFYVAPTALRLLKRAGDSYIENH 381 Query: 432 SLKSLRCLGSVGEPIAAEVWEWYSEKIGKNEIPIVDTYWQTESGSHLVTPLAGGVTPMKP 491 SLKSLRCLGSVGEPIAAEVWEWYSEKIGKNEIPIVDTYWQTESGSHLVTPLAGGVTPMKP Sbjct: 382 SLKSLRCLGSVGEPIAAEVWEWYSEKIGKNEIPIVDTYWQTESGSHLVTPLAGGVTPMKP 441 Query: 492 GSASFPFFGIDAVVLDPNTGEELNTSHAEGVLAVKAAWPSFARTIWKNHDRYLDTYLNPY 551 GSASFPFFGIDAVVLDPNTGEELNTSHAEGVLAVKAAWPSFARTIWKNHDRYLDTYLNPY Sbjct: 442 GSASFPFFGIDAVVLDPNTGEELNTSHAEGVLAVKAAWPSFARTIWKNHDRYLDTYLNPY 501 Query: 552 PGYYFTGDGAAKDKDGYIWILGRVDDVVNVSGHRLSTAEIEAAIIEDPIVAECAVVGFND 611 PGYYFTGDGAAKDKDGYIWILGRVDDVVNVSGHRLSTAEIEAAIIEDPIVAECAVVGFND Sbjct: 502 PGYYFTGDGAAKDKDGYIWILGRVDDVVNVSGHRLSTAEIEAAIIEDPIVAECAVVGFND 561 Query: 612 DLTGQAVAAFVVLKNKSSWSTATDDELQDIKKHLVFTVRKDIGPFAAPKLIILVDDLPKT 671 DLTGQAVAAFVVLKNKSSWSTATDDELQDIKKHLVFTVRKDIGPFAAPKLIILVDDLPKT Sbjct: 562 DLTGQAVAAFVVLKNKSSWSTATDDELQDIKKHLVFTVRKDIGPFAAPKLIILVDDLPKT 621 Query: 672 RSGKIMRRILRKILAGESDQLGDVSTLSNPGIVRHLIDSVKL 713 RSGKIMRRILRKILAGESDQLGDVSTLSNPGIVRHLIDSVKL Sbjct: 622 RSGKIMRRILRKILAGESDQLGDVSTLSNPGIVRHLIDSVKL 663 >5U29-A nrPDB Length = 694 Score = 706 bits (1822), Expect = 0.0, Method: Compositional matrix adjust. Identities = 352/623 (56%), Positives = 439/623 (70%), Gaps = 11/623 (1%) Query: 89 KFFGSKATQFLNWSKPFDKVFIPDPKTGRPSFQNNAWFLNGQLNACYNCVDRHALKTPNK 148 +++ +KA + L+W F V + G + WF G LNA YNC+DRH K P K Sbjct: 79 EWWAAKARETLDWYDDFKTV-----RAGGFEHGDVQWFPEGTLNAAYNCLDRHYYKNPKK 133 Query: 149 KAIIFEGDEPGQGYSITYKELLEEVCQVAQVLTYSMGVRKGDTVAVYMPMVPEAIITLLA 208 AII+E DEP + ++Y+EL++E C+VA VL S GV+KGD V++Y+PM +A LA Sbjct: 134 TAIIYEADEPSESREVSYEELMQETCRVANVLK-SYGVKKGDAVSIYLPMTWQAAAAFLA 192 Query: 209 ISRIGAIHSVVFAGFSSNSLRDRINDGDSKVVITTDESNRGGKVIETKRIVDDALRETPG 268 +RIGAIHS VFAGFS+ SLRDR+ND + KV+ITTDE RGGK I TK+IVD AL++ P Sbjct: 193 CARIGAIHSAVFAGFSAESLRDRVNDCECKVLITTDEGRRGGKTIATKQIVDAALQQCPL 252 Query: 269 VRHVLVYRKTNNPSVAFHAPRDLDWATEKKKYKTYYPCTPVDSEDPLFLLYTSGSTGAPK 328 V +VLV R+T N V RD W E K Y PC + SEDPLF+LYTSGSTG PK Sbjct: 253 VENVLVLRRTGN-KVPMTEGRDKWWDEECAKMPAYCPCERMASEDPLFILYTSGSTGKPK 311 Query: 329 GVQHSTAGYLLGALLTMRYTFDTHQEDVFFTAGDIGWITGHTYVVYGPLLYGCATLVFEG 388 GV HSTAGYLLG LT++Y FD H +D F DIGWITGH+Y++YGPL G T VFE Sbjct: 312 GVVHSTAGYLLGTALTLKYVFDAHPDDRFACMADIGWITGHSYIIYGPLANGITTAVFES 371 Query: 389 TPAYPNYSRYWDIIDEHKVTQFYVAPTALRLLKRAGDSYIENHSLKSLRCLGSVGEPIAA 448 TP YP SRYWD +D+ K TQ Y APTA+RLL+R G+ +++NH L SLR LGSVGEPI Sbjct: 372 TPVYPTPSRYWDFVDKWKATQLYTAPTAIRLLRRMGEDHVKNHDLSSLRVLGSVGEPINP 431 Query: 449 EVWEWYSEKIGKNEIPIVDTYWQTESGSHLVTPLAGGVTPMKPGSASFPFFGIDAVVLDP 508 E W WY++ GKN+ IVDTYW TE+GS + PL G ++ KPGSA+FPFFG+D ++DP Sbjct: 432 EAWHWYNDFAGKNQCAIVDTYWMTETGSISIAPLPGAIS-TKPGSATFPFFGMDVDIIDP 490 Query: 509 NTGEELNTSHAEGVLAVKAAWPSFARTIWKNHDRYLDTYLNPYPGYYFTGDGAAKDKDGY 568 TG+ L + EGVL + WPS ART++++H RYL+TY+ PYPGY+F GDGAA+D DGY Sbjct: 491 QTGQVLEGNDVEGVLVARRPWPSIARTVYRDHKRYLETYMKPYPGYFFFGDGAARDYDGY 550 Query: 569 IWILGRVDDVVNVSGHRLSTAEIEAAIIEDPIVAECAVVGFNDDLTGQAVAAFVVLKNKS 628 +WI GRVDDV+NVSGHRLSTAE+E+A+I VAE AVVG DDLTGQAV AFV +K + Sbjct: 551 MWIKGRVDDVINVSGHRLSTAEVESALILHKGVAETAVVGCADDLTGQAVYAFVTMKPEF 610 Query: 629 SWSTATDDELQDIKKHLVFTVRKDIGPFAAPKLIILVDDLPKTRSGKIMRRILRKILAGE 688 + D+ K L VRK IGPFAAPK I LV DLPKTRSGKIMRR+LRKI+AGE Sbjct: 611 DLKATKE---ADLSKELAIQVRKVIGPFAAPKKIYLVSDLPKTRSGKIMRRVLRKIVAGE 667 Query: 689 SDQLGDVSTLSNPGIVRHLIDSV 711 DQLGD+S++++P IV + V Sbjct: 668 GDQLGDLSSIADPQIVEEVKQKV 690 >5JRH-A nrPDB Length = 660 Score = 585 bits (1509), Expect = e-167, Method: Compositional matrix adjust. Identities = 297/638 (46%), Positives = 414/638 (64%), Gaps = 18/638 (2%) Query: 74 QDYQRLHKESIEDPAKFFGSKATQFLNWSKPFDKVFIPDPKTGRPSFQNNAWFLNGQLNA 133 + Y+ +K+SI DP F+G + + L+W P+ KV G S + W+ +G LN Sbjct: 22 EQYETKYKQSINDPDTFWGEQG-KILDWITPYQKVKNTSFAPGNVSIK---WYEDGTLNL 77 Query: 134 CYNCVDRHALKTPNKKAIIFEGDEPGQGYSITYKELLEEVCQVAQVLTYSMGVRKGDTVA 193 NC+DRH + ++ AII+EGD+ Q I+Y+EL +VC+ A L +G++KGD VA Sbjct: 78 AANCLDRHLQENGDRTAIIWEGDDTSQSKHISYRELHRDVCRFANTL-LDLGIKKGDVVA 136 Query: 194 VYMPMVPEAIITLLAISRIGAIHSVVFAGFSSNSLRDRINDGDSKVVITTDESNRGGKVI 253 +YMPMVPEA + +LA +RIGA+HSV+F GFS ++ RI D S++VIT DE R G+ I Sbjct: 137 IYMPMVPEAAVAMLACARIGAVHSVIFGGFSPEAVAGRIIDSSSRLVITADEGVRAGRSI 196 Query: 254 ETKRIVDDALRE--TPGVRHVLVYRKTNNPSVAFHAPRDLDWATEKKKYKTYYPCTPVDS 311 K+ VDDAL+ V HV+V ++T + + + RDL W +K + +++ Sbjct: 197 PLKKNVDDALKNPNVTSVEHVIVLKRTGS-DIDWQEGRDLWWRDLIEKASPEHQPEAMNA 255 Query: 312 EDPLFLLYTSGSTGAPKGVQHSTAGYLLGALLTMRYTFDTHQEDVFFTAGDIGWITGHTY 371 EDPLF+LYTSGSTG PKGV H+T GYL+ A T +Y FD H D+++ D+GW+TGH+Y Sbjct: 256 EDPLFILYTSGSTGKPKGVLHTTGGYLVYAATTFKYVFDYHPGDIYWCTADVGWVTGHSY 315 Query: 372 VVYGPLLYGCATLVFEGTPAYPNYSRYWDIIDEHKVTQFYVAPTALRLLKRAGDSYIENH 431 ++YGPL G TL+FEG P +P +R ++D+H+V Y APTA+R L GD IE Sbjct: 316 LLYGPLACGATTLMFEGVPNWPTPARMCQVVDKHQVNILYTAPTAIRALMAEGDKAIEGT 375 Query: 432 SLKSLRCLGSVGEPIAAEVWEWYSEKIGKNEIPIVDTYWQTESGSHLVTPLAGGVTPMKP 491 SLR LGSVGEPI E WEWY +KIGK + P+VDT+WQTE+G ++TPL G + +K Sbjct: 376 DRSSLRILGSVGEPINPEAWEWYWKKIGKEKCPVVDTWWQTETGGFMITPLPGAIE-LKA 434 Query: 492 GSASFPFFGIDAVVLDPNTGEELNTSHAEGVLAVKAAWPSFARTIWKNHDRYLDTYLNPY 551 GSA+ PFFG+ ++D N G + EG L + +WP ART++ +H+R+ TY + + Sbjct: 435 GSATRPFFGVQPALVD-NEGHPQEGA-TEGNLVITDSWPGQARTLFGDHERFEQTYFSTF 492 Query: 552 PGYYFTGDGAAKDKDGYIWILGRVDDVVNVSGHRLSTAEIEAAIIEDPIVAECAVVGFND 611 YF+GDGA +D+DGY WI GRVDDV+NVSGHRL TAEIE+A++ P +AE AVVG Sbjct: 493 KNMYFSGDGARRDEDGYYWITGRVDDVLNVSGHRLGTAEIESALVAHPKIAEAAVVGIPH 552 Query: 612 DLTGQAVAAFVVLKNKSSWSTATDDELQDIKKHLVFTVRKDIGPFAAPKLIILVDDLPKT 671 + GQA+ A+V L + S E+++ VRK+IGP A P ++ D LPKT Sbjct: 553 AIKGQAIYAYVTLNHGEEPSPELYAEVRNW-------VRKEIGPLATPDVLHWTDSLPKT 605 Query: 672 RSGKIMRRILRKILAGESDQLGDVSTLSNPGIVRHLID 709 RSGKIMRRILRKI AG++ LGD STL++PG+V L++ Sbjct: 606 RSGKIMRRILRKIAAGDTSNLGDTSTLADPGVVEKLLE 643 >4WD1-A nrPDB Length = 658 Score = 203 bits (516), Expect = 2e-52, Method: Compositional matrix adjust. Identities = 181/659 (27%), Positives = 296/659 (44%), Gaps = 46/659 (6%) Query: 57 RLQPAIATHYSPHLDGLQDYQRLHKESIEDPAKFFGSKATQF-LNWSKPFDKVFIPDPKT 115 R Q A H+ +G Y LH+ S+++ F+ + F + +S P+ +V Sbjct: 24 RFQAWAAEHHGAPAEG--GYAALHRWSVDELDTFWKAVTEWFDVRFSTPYARVL------ 75 Query: 116 GRPSFQNNAWFLNGQLNACYNCVDRHALKTPNKKAIIFEGDEPGQGYSITYKELLEEVCQ 175 G + WF LN + + R A P++ A+++ DE + +T+ EL +V Sbjct: 76 GDRTMPGAQWFPGATLNYAEHAL-RAAGTRPDEPALLYV-DETHEPAPVTWAELRRQVAS 133 Query: 176 VAQVLTYSMGVRKGDTVAVYMPMVPEAIITLLAISRIGAIHSVVFAGFSSNSLRDRINDG 235 +A L ++GVR GD V+ Y+P +P+A++ LLA + +G + + F + S+ DR Sbjct: 134 LAAELR-ALGVRPGDRVSGYLPNIPQAVVALLATAAVGGVWTSCAPDFGARSVLDRFQQV 192 Query: 236 DSKVVITTDESNRGGKVIETKRIVDDALRETPGVRHVLVYRKTNNPSVAFHAPRD-LDWA 294 + V+ T D GGK + + V + RE P +R V+ + P + AP LDW Sbjct: 193 EPVVLFTVDGYRYGGKEHDRRDTVAELRRELPTLRAVI-----HIPLLGTEAPDGTLDWE 247 Query: 295 T-EKKKYKTYYPCTPVDSEDPLFLLYTSGSTGAPKGVQHSTAGYLLGALLTMRYTFDTHQ 353 T + Y P D PL++LY+SG+TG PK + S G L+ L + D Sbjct: 248 TLTAADAEPVYEQVPFDH--PLWVLYSSGTTGLPKAIVQSQGGILVEHLKQLGLHCDLGP 305 Query: 354 EDVFFTAGDIGWITGHTYVVYGPLLYGCATLVFEGTPAYPNYSRYWDIIDEHKVTQFYVA 413 D FF GW+ + ++V G LL G ++++G+P +P W I + T F + Sbjct: 306 GDRFFWYTSTGWMMWN-FLVSG-LLTGTTIVLYDGSPGFPATDAQWRIAERTGATLFGTS 363 Query: 414 PTALRLLKRAGDSYIENHSLKSLRCLGSVGEPIAAEVWEWYSEKIGKNEIPIVDTYWQTE 473 + ++AG + L +++C+ + G P+ + + W ++ D + + Sbjct: 364 AAYVMACRKAGVHPARDLDLSAIQCVATTGSPLPPDGFRWLHDEFAAGG---ADLWIASV 420 Query: 474 SGSHLVTPLAGGVTPMKP---GSASFPFFGIDAVVLDPNTGEELNTSHAEGVLAVKAAWP 530 SG V G P P G P G D DP +G+ L E L V P Sbjct: 421 SGGTDVCSCFAGAVPTLPVHIGELQAPGLGTDLQSWDP-SGDPLTDEVGE--LVVTNPMP 477 Query: 531 SFARTIWKNHD--RYLDTYLNPYPGYYFTGDGAAKDKDGYIWILGRVDDVVNVSGHRLST 588 S W + D RY D+Y + YPG + GD G + I GR D +N G R+ + Sbjct: 478 SMPIRFWNDPDGSRYHDSYFDTYPGVWRHGDWITLTSRGSVVIHGRSDSTLNRQGVRMGS 537 Query: 589 AEIEAAIIEDPIVAECAVVGFNDDLTGQAVAAFVVLKNKSSWSTATDDELQDIKKHLVFT 648 A+I A+ P + E V+G G + FV L ++ DD L D K T Sbjct: 538 ADIYEAVERLPEIRESLVIGIEQPDGGYWMPLFVHLAPGAT----LDDALLDRIKR---T 590 Query: 649 VRKDIGPFAAPKLIILVDDLPKTRSGKIMRRILRKILAGESDQLGDVSTLSNPGIVRHL 707 +R ++ P P +I V +P T +GK + ++++L G + NPG + +L Sbjct: 591 IRVNLSPRHVPDEVIEVPGIPHTLTGKRIEVPVKRLLQGTP-----LDKAVNPGSIDNL 644 >3ETC-A nrPDB Length = 580 Score = 171 bits (432), Expect = 1e-42, Method: Compositional matrix adjust. Identities = 160/582 (27%), Positives = 256/582 (43%), Gaps = 69/582 (11%) Query: 120 FQNNAWFLNGQ-LNACYNCVDRHALKTPNKKAIIFEGDEPGQGYSITYKELLEEVCQVAQ 178 FQ N L + N Y+ VD +A +P K A+I+ D+ G T+K+L + A Sbjct: 43 FQENFKILVPENFNFAYDVVDVYARDSPEKLAMIW-CDDYGNEKIFTFKDLKYYSDKAAN 101 Query: 179 VLTYSMGVRKGDTVAVYMPMVPEAIITLLAISRIGAIHSVVFAGFSSNSLRDRINDGDSK 238 G+ KGD V + + + +L + ++GAI + + RI K Sbjct: 102 FFV-KHGIGKGDYVMLTLKSRYDFWYCMLGLHKLGAIAVPATHMLKTRDIVYRIEKAGLK 160 Query: 239 VVITTDESNRGGKVIETKRIVDDALRETPGVRHVLVYRKTNNPSVAFHAPRDLDWATEKK 298 +++ E + VD+A E + +K D E+ Sbjct: 161 MIVCIAEDD-------VPEQVDEAHAECGDIP----LKKAKVGGDVLEGWIDFRKELEES 209 Query: 299 KYKTYYPCTPVDS--EDPLFLLYTSGSTGAPKGVQHSTAGYLLGALLTMRYTFDTHQEDV 356 P V + ED + ++SG+ G PK V+H Y LG +LT +Y + + + Sbjct: 210 SPIFERPTGEVSTKNEDICLVYFSSGTAGFPKMVEHDNT-YPLGHILTAKYWQNVEDDGL 268 Query: 357 FFTAGDIGWITGHTYVVYGPLLYGCATLVFEGTPAYPNYSRY-----WDIIDEHKVTQFY 411 +T D GW +YG + GCA V+ +Y R+ + ++ VT F Sbjct: 269 HYTVADSGWGKCVWGKLYGQWIAGCAVFVY-------DYDRFEAKNMLEKASKYGVTTFC 321 Query: 412 VAPTALRLLKRAGDSYIENHSLKSLRCLGSVGEPIAAEVWEWYSEKIGKNEIPIVDTYWQ 471 PT R L + + +++ +L+ GEP+ EV+ + E G I +++ + Q Sbjct: 322 APPTIYRFLIKED---LSHYNFSTLKYAVVAGEPLNPEVFNRFLEFTG---IKLMEGFGQ 375 Query: 472 TESGSHLVTPLAGGVTPMKPGSASFPFFGIDAVVLDPN-----TGEE----LNTSHAE-- 520 TE+ +VT KPGS P G ++D + GEE +NT + Sbjct: 376 TET---VVTIATFPWMEPKPGSIGKPTPGYKIELMDRDGRLCEVGEEGEIVINTMEGKPV 432 Query: 521 GVLAVKAAWPSFARTIWKNHDRYLDTYLNPYPGYYFTGDGAAKDKDGYIWILGRVDDVVN 580 G+ P W HD GYY TGD A D+DGY+W +GR DD++ Sbjct: 433 GLFVHYGKDPERTEETW--HD-----------GYYHTGDMAWMDEDGYLWFVGRADDIIK 479 Query: 581 VSGHRLSTAEIEAAIIEDPIVAECAVVGFNDDLTGQAVAAFVVLKNKSSWSTATDDELQD 640 SG+++ E+E+A+I+ P V ECA+ G D + GQ + A +VL + S + +ELQD Sbjct: 480 TSGYKVGPFEVESALIQHPAVLECAITGVPDPVRGQVIKATIVLTKDYTPSDSLKNELQD 539 Query: 641 IKKHLVFTVRKDIGPFAAPKLIILVDDLPKTRSGKIMRRILR 682 K++ P+ P++I V +LPKT SGKI R +R Sbjct: 540 HVKNVT-------APYKYPRIIEFVPELPKTISGKIRRVEIR 574 >3GPC-A nrPDB Length = 570 Score = 164 bits (415), Expect = 1e-40, Method: Compositional matrix adjust. Identities = 147/528 (27%), Positives = 238/528 (45%), Gaps = 43/528 (8%) Query: 159 GQGYSITYKELLEEVCQVAQVLTYSMGVRKGDTVAVYMPMVPEAIITLLAISRIGAIHSV 218 G+ ++EL E Q A VL+ + G+++GD VAV +P VPE + +L R G I Sbjct: 69 GKELMWNFRELSENSQQAANVLSGACGLQRGDRVAVVLPRVPEWWLVILGCIRAGLIFMP 128 Query: 219 VFAGFSSNSLRDRINDGDSKVVITTDESNRGGKVIETKRIVDDALRETPGVR-HVLVYRK 277 S + R+ +K ++ DE VI+ VD E P +R +LV K Sbjct: 129 GTIQMKSTDILYRLQMSKAKAIVAGDE------VIQE---VDTVASECPSLRIKLLVSEK 179 Query: 278 TNNPSVAFHAPRDLDWATEKKKYKTYYPCTPVDSEDPLFLLYTSGSTGAPKGVQHSTAGY 337 + + + F + L+ A+ T + C S++ + +TSG++G PK +HS + Sbjct: 180 SCDGWLNFK--KLLNEAS------TTHHCVETGSQEASAIYFTSGTSGLPKMAEHSYSSL 231 Query: 338 LLGALLTMRYTFDTHQEDVFFTAGDIGWITGHTYVVYGPLLYGCATLVFEGTPAYPNYSR 397 L A + +T D+ +T D GWI + P G T V P + Sbjct: 232 GLKAKMDAGWT-GLQASDIMWTISDTGWILNILCSLMEPWALGACTFVH----LLPKFDP 286 Query: 398 Y--WDIIDEHKVTQFYVAPTALRLLKRAGDSYIENHSLKSLRCLGSVGEPIAAEVWEWYS 455 + + + AP R+L + + ++ L+ +VGE + E E + Sbjct: 287 LVILKTLSSYPIKSMMGAPIVYRMLLQQD---LSSYKFPHLQNCVTVGESLLPETLENWR 343 Query: 456 EKIGKNEIPIVDTYWQTESGSHLVTPLAGGVTPMKPGSASFPFFGIDAVVLDPNTGEELN 515 + G + I ++Y QTE+G +T + +KPG D ++D + G L Sbjct: 344 AQTG---LDIRESYGQTETG---LTCMVSKTMKIKPGYMGTAASCYDVQIID-DKGNVLP 396 Query: 516 TSHAEGVLAVKAAWPSFARTIWKNH-DRYLDTYLNPYPGYYFTGDGAAKDKDGYIWILGR 574 EG + ++ P I+ + D T N ++ GD KD+DGY +GR Sbjct: 397 PG-TEGDIGIRVK-PIRPIGIFSGYVDNPDKTAANIRGDFWLLGDRGIKDEDGYFQFMGR 454 Query: 575 VDDVVNVSGHRLSTAEIEAAIIEDPIVAECAVVGFNDDLTGQAVAAFVVLKNKSSWSTAT 634 DD++N SG+R+ +E+E A++E P V E AV+ D + G+ V AFVVL S Sbjct: 455 ADDIINSSGYRIGPSEVENALMEHPAVVETAVISSPDPVRGEVVKAFVVLA-----SQFL 509 Query: 635 DDELQDIKKHLVFTVRKDIGPFAAPKLIILVDDLPKTRSGKIMRRILR 682 + + + K L V+ P+ P+ I V +LPKT +GKI R LR Sbjct: 510 SHDPEQLTKELQQHVKSVTAPYKYPRKIEFVLNLPKTVTGKIQRAKLR 557 >4WV3-A nrPDB Length = 529 Score = 137 bits (346), Expect = 1e-32, Method: Compositional matrix adjust. Identities = 148/551 (26%), Positives = 228/551 (41%), Gaps = 50/551 (9%) Query: 135 YNCVD--RHALKTPNKKAIIFEGDEPGQGYSITYKELLEEVCQVAQVLTYSMGVRKGDTV 192 YN VD L K +F D +T++++ E QV L +GVR G+ V Sbjct: 10 YNAVDILERNLPVRANKTALFTPDR-----EMTFRQVSNEANQVGNALK-GLGVRFGECV 63 Query: 193 AVYMPMVPEAIITLLAISRIGAIHSVVFAGFSSNSLRDRINDGDSKVVITTDESNRGGKV 252 + E + + I ++GAI + + D ++V+I E + Sbjct: 64 GLLTLDSAEWVTSFFGIVKLGAIAVGINTLLKPPEYEYILRDCRARVLIVHQEFL---PL 120 Query: 253 IETKRIVDDALRETPGVRHVLVYRKTNNPS-VAFHAPRDLDWATEKKKYKTYYPCTPVDS 311 IE+ R P + H++V + ++F+ DW + T Sbjct: 121 IESIR------GNLPMLEHIVVIGEGPQEGYLSFN-----DWI---RPQPTTLEAAQSHR 166 Query: 312 EDPLFLLYTSGSTGAPKGVQHSTAGYLLGALLTMRYTFDTHQEDVFFTAGDIGWITGHTY 371 ED L Y+SG+TG PKG+ H+ Y L A L + D F + + G Sbjct: 167 EDICSLNYSSGTTGGPKGIPHAHKDYPLTAQLWGVNVLGLRESDRTFALAKLFFTFGTGG 226 Query: 372 VVYGPLLYGCATLVFEGTPAYPNYSRYWDIIDEHKVTQFYVAPTALRLLKRAGDSYIENH 431 + P G + ++F G A S I K T FY APT D H Sbjct: 227 NLIFPWYVGASCVLFPG--AARVASNVLSTISRFKPTIFYNAPTGYAAALALKD--FSQH 282 Query: 432 SLKSLRCLGSVGEPIAAEVWEWYSEKIGKNEIPIVDTYWQTESGSHLVTPLAGGVTPMKP 491 L SLR S E + A +W + E G + I+D TE+ ++ G + +P Sbjct: 283 DLSSLRLCVSASEALPAALWYAWKEATG---VDIIDGIGCTENFHIFISNRPGDI---RP 336 Query: 492 GSASFPFFGIDAVVLDPNTGEELNTSHAEGVLAVKAAWPSFARTIWKNHDRYLDTYLNPY 551 GS+ P G + ++D +E T A + V + A + W N ++ T+ + Sbjct: 337 GSSGKPVEGYELKLVD----DEGKTVPAGEIGNVLLRSETAALSYWHNFEKSRQTFQGEW 392 Query: 552 PGYYFTGDGAAKDKDGYIWILGRVDDVVNVSGHRLSTAEIEAAIIEDPIVAECAVVGFND 611 TGD D DGY W GR DD++ V G +S E+E+ +I+ P V ECAV+G D Sbjct: 393 LA---TGDKYFVDADGYYWHAGRSDDMLKVGGIWVSPVEVESTLIQHPAVQECAVIGCPD 449 Query: 612 DLTGQAVAAFVVLKNKSSWSTATDDELQDIKKHLVFTVRKDIGPFAAPKLIILVDDLPKT 671 AF++LK + S A ++ I H + + + P+ I V +LPKT Sbjct: 450 QSRLIKPKAFIILKPEQIPSEAL---IRQITDHCT----EKMAAYKRPRWIEFVTELPKT 502 Query: 672 RSGKIMRRILR 682 +GKI R LR Sbjct: 503 ATGKIQRFKLR 513 >5IE2-A nrPDB Length = 514 Score = 127 bits (318), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 131/546 (23%), Positives = 244/546 (44%), Gaps = 59/546 (10%) Query: 142 ALKTPNKKAIIFEGDEPGQGYSITYKELLEEVCQVAQVLTYSMGVRKGDTVAVYMPMVPE 201 A K P+++A+ G +++T+ L + + + A L G++ GD VA+ P E Sbjct: 14 AKKFPDRRALSVSGK-----FNLTHARLHDLIERAASRLVSDAGIKPGDVVALTFPNTVE 68 Query: 202 AIITLLAISRIGAIHSVVFAGFSSNSLRDRINDGDSKVVITTDESNRGGKVIETKRIVDD 261 +I LA+ R A + + A +++ ++D DSK+++T+ E N + +K + Sbjct: 69 FVIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLLLTSKEGNAPAQEAASKLKISH 128 Query: 262 ALRETPGVRHVLVYRKTNNPSVAFHAPRDLDWATEKKKYKTYYPCTPVDSEDPLFLLYTS 321 LV ++ SV +D ATE + +D L+TS Sbjct: 129 VTATLLDAGSDLVLSVADSDSV-------VDSATELVNH----------PDDGALFLHTS 171 Query: 322 GSTGAPKGVQHSTAGYLLGALLTMRYTFDTHQEDVFFTAGDIGWITGHTYVVYGPLLYGC 381 G+T PKGV T L ++ ++ + + D + I H + + LL Sbjct: 172 GTTSRPKGVP-LTQLNLASSVKNIKAVYKLTESD----STVIVLPLFHVHGLLAGLLSSL 226 Query: 382 ATLVFEGTPAYPNYS--RYWDIIDEHKVTQFYVAPTALRLLKRAGDSYIENHSLKSLRCL 439 PA +S +W + ++ T + PT +++ S+ E K LR + Sbjct: 227 GAGAAVTLPAAGRFSATTFWPDMKKYNATWYTAVPTIHQIILDRHASHPETEYPK-LRFI 285 Query: 440 GSVGEPIAAEVWEWYSEKIGKNEIPIVDTYWQTESGSHLVT----PLAGGVTPMKPGSAS 495 S +A + E G P+++ Y TE+ +HL++ P G P KPGS Sbjct: 286 RSCSASLAPVILSRLEEAFGA---PVLEAYAMTEA-THLMSSNPLPEEG---PHKPGSVG 338 Query: 496 FPFFGIDAVVLDPNTGEELNTSHAEGVLAVKAAWPSFARTIWKNHDRYLDTYLNPYPGYY 555 P G + +L N E+ + +G + ++ P+ + N + + G++ Sbjct: 339 KPV-GQEMAIL--NEKGEIQEPNNKGEVCIRG--PNVTKGYKNNPEANKAGFEF---GWF 390 Query: 556 FTGDGAAKDKDGYIWILGRVDDVVNVSGHRLSTAEIEAAIIEDPIVAECAVVGFNDDLTG 615 TGD D DGY+ ++GR+ +++N G ++S E++A ++ P V++ G D+ G Sbjct: 391 HTGDIGYFDTDGYLHLVGRIKELINRGGEKISPIEVDAVLLTHPDVSQGVAFGVPDEKYG 450 Query: 616 QAVAAFVVLKNKSSWSTATDDELQDIKKHLVFTVRKDIGPFAAPKLIILVDDLPKTRSGK 675 + + V+ + +T T+++++ +K++ F PK + + D+LPKT SGK Sbjct: 451 EEINCAVIPRE---GTTVTEEDIKAF-------CKKNLAAFKVPKRVFITDNLPKTASGK 500 Query: 676 IMRRIL 681 I RRI+ Sbjct: 501 IQRRIV 506 >3A9U-A nrPDB Length = 536 Score = 125 bits (315), Expect = 5e-29, Method: Compositional matrix adjust. Identities = 134/519 (25%), Positives = 229/519 (44%), Gaps = 67/519 (12%) Query: 184 MGVRKGDTVAVYMPMVPEAIITLLAISRIGAIHSVVFAGFSSNSLRDRINDGDSKVVITT 243 +G+++GD + +++P PE ++ L S GAI + + L +K++IT Sbjct: 69 IGIQQGDVIMLFLPSSPEFVLAFLGASHRGAIITAANPFSTPAELAKHAKASRAKLLIT- 127 Query: 244 DESNRGGKVIETKRIVDDALRETPGVRHVLVYRKTNNPSVAFHAPRDLDWATEKKKYKTY 303 + +++ D A RE+ V V + P H +L A E + Sbjct: 128 -------QACYYEKVKDFA-RES----DVKVMCVDSAPDGCLHF-SELTQADENEA---- 170 Query: 304 YPCTPVDSEDPLFLLYTSGSTGAPKGVQHSTAGYLLGALLTM---RYTFDTHQEDVFFTA 360 P + +D + L Y+SG+TG PKGV + G + + H EDV Sbjct: 171 -PQVDISPDDVVALPYSSGTTGLPKGVMLTHKGLITSVAQQVDGDNPNLYFHSEDVILCV 229 Query: 361 GDIGWITGHTYVVYGPLLYGCATLVFEGTPAYPNYSRYWDIIDEHKVTQFYVAPTALRLL 420 + I ++ L G L+ P + +I+++KV+ V P + + Sbjct: 230 LPMFHIYALNSIMLCGLRVGAPILIM---PKF-EIGSLLGLIEKYKVSIAPVVPPVMMSI 285 Query: 421 KRAGDSYIENHSLKSLRCLGSVGEPIAAEVWEWYSEKIGKNEIPIVDTYWQTESGSHLVT 480 ++ D ++ H L SLR + S G P+ E+ + K + + Y TE+G L Sbjct: 286 AKSPD--LDKHDLSSLRMIKSGGAPLGKELEDTVRAKFPQARLG--QGYGMTEAGPVLAM 341 Query: 481 PLAGGVTP--MKPGSASFPFFGIDAVVLDPNTGEELNTSHAEGVLAVKAAWPSFARTIWK 538 LA P +KPG+ + ++DP TG L + G + ++ Sbjct: 342 CLAFAKEPFDIKPGACGTVVRNAEMKIVDPETGASLPRNQP-GEICIRG----------- 389 Query: 539 NHDRYLDTYLNP---------YPGYYFTGDGAAKDKDGYIWILGRVDDVVNVSGHRLSTA 589 D+ + YLN G+ TGD D D ++I+ R+ +++ G +++ A Sbjct: 390 --DQIMKGYLNDPEATSRTIDKEGWLHTGDIGYIDDDDELFIVDRLKELIKYKGFQVAPA 447 Query: 590 EIEAAIIEDPIVAECAVVGFNDDLTGQAVAAFVVLKNKSSWSTATDDEL-QDIKKHLVFT 648 E+EA +I P +++ AVVG D+ G+ AFVV KS S AT+DE+ Q I K ++F Sbjct: 448 ELEALLIAHPEISDAAVVGLKDEDAGEVPVAFVV---KSEKSQATEDEIKQYISKQVIFY 504 Query: 649 VRKDIGPFAAPKLIILVDDLPKTRSGKIMRRILRKILAG 687 R K + ++ +PK SGKI+R+ L++ LAG Sbjct: 505 KRI--------KRVFFIEAIPKAPSGKILRKNLKEKLAG 535 >4EAT-A nrPDB Length = 524 Score = 123 bits (309), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 115/402 (28%), Positives = 182/402 (45%), Gaps = 28/402 (6%) Query: 288 PRDLDWATEKKKYKTYYPCTPVDSEDPLFLLYTSGSTGAPKGVQHSTAGYLLGALLTMRY 347 P ++D+A + ++DP F LY+SGSTG PKGV H+ A + L R Sbjct: 149 PGEVDFAEFVGAHAPLEKPAATQADDPAFWLYSSGSTGRPKGVVHTHANPYWTSELYGRN 208 Query: 348 TFDTHQEDVFFTAGDIGWITGHTYVVYGPLLYGCATLVFEGTPAYPN--YSRYWDIIDEH 405 T ++DV F+A + + G + P+ G TL+ P P+ + R+ + Sbjct: 209 TLHLREDDVCFSAAKLFFAYGLGNALTFPMTVGATTLLMGERPT-PDAVFKRWLGGVGGV 267 Query: 406 KVTQFYVAPTALRLLKRAGDSYIENHSLKSLRCLGSVGEPIAAEVWEWYSEKIGKNEIPI 465 K T FY APT + A + + + +LR S GE + AE+ + + G + I Sbjct: 268 KPTVFYGAPTGYAGMLAAPN--LPSRDQVALRLASSAGEALPAEIGQRFQRHFG---LDI 322 Query: 466 VDTYWQTESGSHLVTPLAGGVTPMKPGSASFPFFGIDAVVLDPNTGEELNTSHAEGVLAV 525 VD TE ++ L V + G+ +P G + G + G L + Sbjct: 323 VDGIGSTEMLHIFLSNLPDRV---RYGTTGWPVPGYQIELRGDGGGPVADGE--PGDLYI 377 Query: 526 KAAWPSFARTIWKNHDRYLDTYLNPYPGYYFTGDGAAKDKDGYIWILGRVDDVVNVSGHR 585 PS A W N + DT+ G+ +GD ++ DG GR DD++ VSG Sbjct: 378 HG--PSSATMYWGNRAKSRDTFQG---GWTKSGDKYVRNDDGSYTYAGRTDDMLKVSGIY 432 Query: 586 LSTAEIEAAIIEDPIVAECAVVGFNDDLTGQAVAAFVVLKNKSSWSTATDDELQDIKKHL 645 +S EIEA +++ P V E AVVG D+ A+VV + T ++ EL+ Sbjct: 433 VSPFEIEATLVQHPGVLEAAVVGVADEHGLTKPKAYVVPRPG---QTLSETELKTF---- 485 Query: 646 VFTVRKDIGPFAAPKLIILVDDLPKTRSGKIMRRILRKILAG 687 ++ + P+ P+ + V +LPKT +GKI R LR+ + G Sbjct: 486 ---IKDRLAPYKYPRSTVFVAELPKTATGKIQRFKLREGVLG 524 >4FUQ-A nrPDB Length = 503 Score = 121 bits (303), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 149/542 (27%), Positives = 237/542 (43%), Gaps = 59/542 (10%) Query: 143 LKTPNKKAIIFEGDEPGQGYSITYKELLEEVCQVAQVLTYSMGVRKGDTVAVYMPMVPEA 202 L P+K AI E G I+Y EL+ +VA VL + G++ GD VA EA Sbjct: 13 LDDPHKLAI-----ETAAGDKISYAELVARAGRVANVLV-ARGLQVGDRVAAQTEKSVEA 66 Query: 203 IITLLAISRIGAIHSVVFAGFSSNSLRDRINDGDSKVVITTDESNRGGKVIETKRIVDDA 262 ++ LA R G ++ + ++ + L I D + K+V+ D S R G ++ Sbjct: 67 LVLYLATVRAGGVYLPLNTAYTLHELDYFITDAEPKIVVC-DPSKRDGIAAIAAKVGATV 125 Query: 263 LRETPGVRHVLVYRKTNNPSVAFHAPRDLDWATEKKKYKTYYPCTPVDSEDPLFLLYTSG 322 P R L T+ + A A +D ++D +LYTSG Sbjct: 126 ETLGPDGRGSL----TDAAAGASEAFATIDRG----------------ADDLAAILYTSG 165 Query: 323 STGAPKGVQHSTAGYLLGALLTMRYTFDTHQEDVFFTAGDIGWITGHTYVVYGPLLYGCA 382 +TG KG S +L + Y + +DV A I + T +V L+ Sbjct: 166 TTGRSKGAMLSHDNLASNSLTLVDY-WRFTPDDVLIHALPI-YHTHGLFVASNVTLFARG 223 Query: 383 TLVFEGTPAYPNYSRYWDIIDEHKVTQFYVAPTA-LRLLKRAGDSYIENHSLKSLRCLGS 441 +++F P + + + D++ + T PT RLL+ + + +R S Sbjct: 224 SMIF--LPKF-DPDKILDLM--ARATVLMGVPTFYTRLLQ---SPRLTKETTGHMRLFIS 275 Query: 442 VGEPIAAEVWEWYSEKIGKNEIPIVDTYWQTESGSHLVTPLAGGVTPMKPGSASFPFFGI 501 P+ A+ +S K G +++ Y TE+ + P G P G A P G+ Sbjct: 276 GSAPLLADTHREWSAKTGH---AVLERYGMTETNMNTSNPYDGDRVPGAVGPA-LP--GV 329 Query: 502 DAVVLDPNTGEELNTSHAEGVLAVKAAWPSFARTIWKNHDRYLDTYLNPYPGYYFTGDGA 561 A V DP TG+EL G++ VK P+ + W+ ++ + + G++ TGD Sbjct: 330 SARVTDPETGKELPRGDI-GMIEVKG--PNVFKGYWRMPEKTKSEFRDD--GFFITGDLG 384 Query: 562 AKDKDGYIWILGRVDDVVNVSGHRLSTAEIEAAIIEDPIVAECAVVGFNDDLTGQAVAAF 621 D+ GY+ ILGR D+V G + EIE+ I P V E AV+G G+ V A Sbjct: 385 KIDERGYVHILGRGKDLVITGGFNVYPKEIESEIDAMPGVVESAVIGVPHADFGEGVTA- 443 Query: 622 VVLKNKSSWSTATDDELQDIKKHLVFTVRKDIGPFAAPKLIILVDDLPKTRSGKIMRRIL 681 VV+++K AT DE Q ++ + + F PK +I VDDLP+ GK+ + +L Sbjct: 444 VVVRDKG----ATIDEAQ-----VLHGLDGQLAKFKMPKKVIFVDDLPRNTMGKVQKNVL 494 Query: 682 RK 683 R+ Sbjct: 495 RE 496 >5BSW-A nrPDB Length = 541 Score = 116 bits (290), Expect = 4e-26, Method: Compositional matrix adjust. Identities = 129/528 (24%), Positives = 228/528 (43%), Gaps = 82/528 (15%) Query: 182 YSMGVRKGDTVAVYMPMVPEAIITLLAISRIGAIHSVVFAGFSSNSLRDRINDGDSKVVI 241 + G++ DT+ + +P PE + + S +GAI ++ F+ + + +K+++ Sbjct: 70 HKQGIQPKDTIMILLPNSPEFVFAFIGASYLGAISTMANPLFTPAEVVKQAKASSAKIIV 129 Query: 242 TTDESNRGGKVIE------TKRIVDDALRETPGVRHVLVYRKTNNPSVAFHAPRDLDWAT 295 T ++ KV + K I D+ E G H V + N + Sbjct: 130 T--QACHVNKVKDYAFENDVKIICIDSAPE--GCLHFSVLTQANEHDI------------ 173 Query: 296 EKKKYKTYYPCTPVDSEDPLFLLYTSGSTGAPKGVQHSTAGYLLGALLTM---RYTFDTH 352 P + +D + L Y+SG+TG PKGV + G + + H Sbjct: 174 ---------PEVEIQPDDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLYIH 224 Query: 353 QEDVFFTAGDIGWITGHTYVVYGPLLYGCATLVFEGTPAYPNYSRYWDIIDEHKVTQF-Y 411 EDV + I V+ L G A L+ + + + ++I +KVT + Sbjct: 225 SEDVMLCVLPLFHIYSLNSVLLCGLRVGAAILIMQKF----DIVSFLELIQRYKVTIGPF 280 Query: 412 VAPTALRLLKRAGDSYIENHSLKSLRCLGSVGEPIAAEVWEWYSEKIGKNEIPIVDTYWQ 471 V P L + K ++++ L S+R + S P+ E+ + K ++ Y Sbjct: 281 VPPIVLAIAK---SPMVDDYDLSSVRTVMSGAAPLGKELEDTVRAKFPNAKLG--QGYGM 335 Query: 472 TESGSHLVTPLAGGVTP--MKPGSASFPFFGIDAVVLDPNTGEELNTSHAEGVLAVKAAW 529 TE+G L LA P +K G+ + ++DP TG L + + G + ++ Sbjct: 336 TEAGP-LAMCLAFAKEPFEIKSGACGTVVRNAEMKIVDPKTGNSLPRNQS-GEICIRG-- 391 Query: 530 PSFARTIWKNHDRYLDTYLNP---------YPGYYFTGDGAAKDKDGYIWILGRVDDVVN 580 D+ + YLN G+ +TGD D D ++I+ R+ +++ Sbjct: 392 -----------DQIMKGYLNDPEATARTIDKEGWLYTGDIGYIDDDDELFIVDRLKELIK 440 Query: 581 VSGHRLSTAEIEAAIIEDPIVAECAVVGFNDDLTGQAVAAFVVLKNKSSWSTATDDELQD 640 G +++ AE+EA ++ P +++ AVV D+ G+ AFVV +S+ ST T+DE++D Sbjct: 441 YKGFQVAPAELEALLLNHPNISDAAVVPMKDEQAGEVPVAFVV---RSNGSTITEDEVKD 497 Query: 641 -IKKHLVFTVRKDIGPFAAPKLIILVDDLPKTRSGKIMRRILRKILAG 687 I K ++F R K + VD +PK+ SGKI+R+ LR LA Sbjct: 498 FISKQVIFYKRI--------KRVFFVDAIPKSPSGKILRKDLRAKLAA 537 >3R44-A nrPDB Length = 517 Score = 115 bits (287), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 134/536 (25%), Positives = 224/536 (41%), Gaps = 72/536 (13%) Query: 157 EPGQGYSITYKELLEEVCQVAQVLTYSMGVRKGDTVAVYMPMVPEAIITLLAISRIGAIH 216 EP +TY ++ + A VLT ++G+ KGD VA+ MP E +++GA+ Sbjct: 37 EPSTDVRMTYAQMNALANRCADVLT-ALGIAKGDRVALLMPNSVEFCCLFYGAAKLGAVA 95 Query: 217 SVVFAGFSSNSLRDRINDGDSKVVITTDESNRGGKVIETKRIVDDALRETPGVRHVLVYR 276 + ++ + ++D SKVVI S VI+ R A + PG Sbjct: 96 VPINTRLAAPEVSFILSDSGSKVVIYGAPS---APVIDAIR----AQADPPGTVT----- 143 Query: 277 KTNNPSVAFHAPRDLDW------ATEKKKYKTYYPCTPVDSEDPLFLLYTSGSTGAPKGV 330 DW A + P +D LF++YTSG+TG PKGV Sbjct: 144 ---------------DWIGADSLAERLRSAAADEPAVECGGDDNLFIMYTSGTTGHPKGV 188 Query: 331 QHSTAGYLLGALLTMRYTFDTHQEDVFFTAGDIGWITGHTYVVYGPLLYGCATLVFEGTP 390 H T + A + T D D + + T V++ + TL+ P Sbjct: 189 VH-THESVHSAASSWASTIDVRYRDRLLLPLPMFHVAALTTVIFSAMR--GVTLI--SMP 243 Query: 391 AYPNYSRYWDIIDEHKVTQFYVAPTALRLLKRAGDSYIENHSLKSLRCLGSVGEPIAAEV 450 + + ++ W +I E +V P L +++ + R + G P+ + Sbjct: 244 QF-DATKVWSLIVEERVCIGGAVPAILNFMRQVPE--FAELDAPDFRYFITGGAPMPEAL 300 Query: 451 WEWYSEKIGKNEIPIVDTYWQTES---GSHLVTPLAGGVTPMKPGSASFPFFGIDAVVLD 507 + Y+ K I +V Y TES G+ L++ A K GSA D V Sbjct: 301 IKIYAAK----NIEVVQGYALTESCGGGTLLLSEDA----LRKAGSAGRATMFTDVAV-- 350 Query: 508 PNTGEELNTSHAEGVLAVKAAWPSFARTIWKNHDRYLDTYLNPYPGYYFTGDGAAKDKDG 567 + + H EG + +K+ + W + D + N G++ TGD D +G Sbjct: 351 -RGDDGVIREHGEGEVVIKS--DILLKEYWNRPEATRDAFDN---GWFRTGDIGEIDDEG 404 Query: 568 YIWILGRVDDVVNVSGHRLSTAEIEAAIIEDPIVAECAVVGFNDDLTGQAVAAFVVLKNK 627 Y++I R+ D++ G + AEIE+ II P V+E AV+G D+ G+ AA VV Sbjct: 405 YLYIKDRLKDMIISGGENVYPAEIESVIIGVPGVSEVAVIGLPDEKWGEIAAAIVV---- 460 Query: 628 SSWSTATDDELQDIKKHLVFTVRKDIGPFAAPKLIILVDDLPKTRSGKIMRRILRK 683 A +E+ + + +V + + PK +I + +P+ +GKI++ +LR+ Sbjct: 461 -----ADQNEVSE--QQIVEYCGTRLARYKLPKKVIFAEAIPRNPTGKILKTVLRE 509 >3DLP-X nrPDB Length = 504 Score = 112 bits (280), Expect = 6e-25, Method: Compositional matrix adjust. Identities = 144/565 (25%), Positives = 222/565 (39%), Gaps = 81/565 (14%) Query: 131 LNACYNCVDRHALKTPNKKAIIFEGDEPGQGYSITYKELLEEVCQVAQVLTYSMGVRKGD 190 + + R A + P+ A+ P +G +T+ EL V VA L ++ G+R Sbjct: 1 MQTVNEMLRRAATRAPDHCALAV----PARGLRLTHAELRARVEAVAARL-HADGLRPQQ 55 Query: 191 TVAVYMPMVPEAIITLLAISRIGAIHSVVFAGFSSNSLRDRINDGDSKVVITTDESNRGG 250 VAV P + +I +LA+ R+GA+ +++ S L + I G+ Sbjct: 56 RVAVVAPNSADVVIAILALHRLGAVPALLNPRLKSAELAELIKRGEMT-----------A 104 Query: 251 KVIETKRIVDDALRETPGVRHVLVYRKTNNPSVAFHAPRDLDWATEKKKYKTYYPCTPVD 310 VI R V DA +++ + + F D + + Y P Sbjct: 105 AVIAVGRQVADA-----------IFQSGSGARIIFLG----DLVRDGEPYSYGPPIEDPQ 149 Query: 311 SE--DPLFLLYTSGSTGAPKGVQHSTAGYLLGALLTMRYTFDTHQEDVFFTAGDIGWITG 368 E P F+ YTSG+TG PK A++ R + V F + +G G Sbjct: 150 REPAQPAFIFYTSGTTGLPKA-----------AIIPQRAA----ESRVLFMSTQVGLRHG 194 Query: 369 HTYVVYG--PLLYGC-------ATLVFEGTPAYPNYSRYWD---IIDEHKVTQFYVAPTA 416 VV G PL + A L +GT R D ++ + +VT + PT Sbjct: 195 RHNVVLGLMPLYHVVGFFAVLVAALALDGTYVVVEEFRPVDALQLVQQEQVTSLFATPTH 254 Query: 417 LRLLKRAGDSYIENHSLKSLRCLGSVGEPIAAEVWEWYSEKIGKNEIPIVDTYWQTESGS 476 L L A + L SLR + G + V E + + + V+ Y TE+ + Sbjct: 255 LDALAAAAAHAGSSLKLDSLRHVTFAGATMPDAVLETVHQHLPGEK---VNIYGTTEAMN 311 Query: 477 HLVTPLAGGVTPMKPGSASFPFFGIDAVVLDPNTGEELNTSHAEGVLAVKAAWPSFARTI 536 L T M PG FF +V +E+ + EG L V A+ +F Sbjct: 312 SLYMRQPKTGTEMAPG-----FFSEVRIVRIGGGVDEIVANGEEGELIVAASDSAFVG-- 364 Query: 537 WKNHDRYLDTYLNPYPGYYFTGDGAAKDKDGYIWILGRVDDVVNVSGHRLSTAEIEAAII 596 + N + L G+Y T D A +G + ILGRV D++ G + +EIE + Sbjct: 365 YLNQPQATAEKLQD--GWYRTSDVAVWTPEGTVRILGRVPDMIISGGENIHPSEIERVLG 422 Query: 597 EDPIVAECAVVGFNDDLTGQAVAAFVVLKNKSSWSTATDDELQDIKKHLVFTVRKDIGPF 656 P V E V+G D GQ+V A VV + + S D F ++ F Sbjct: 423 TAPGVTEVVVIGLADQRWGQSVTACVVPRLGETLSADALD---------TFCRSSELADF 473 Query: 657 AAPKLIILVDDLPKTRSGKIMRRIL 681 PK ++D LPK K++RR L Sbjct: 474 KRPKRYFILDQLPKNALNKVLRRQL 498 >5BUS-A nrPDB Length = 494 Score = 109 bits (273), Expect = 4e-24, Method: Compositional matrix adjust. Identities = 130/569 (22%), Positives = 233/569 (40%), Gaps = 93/569 (16%) Query: 129 GQLNACYNCVDRHALKTPNKKAIIFEGDEPGQGYSITYKELLEEVCQVAQVLTYSMGVRK 188 G L N + + A TP + A+I+E ++T+ EL ++A+ L + VRK Sbjct: 2 GMLTEQPNWLMQRAQLTPERIALIYEDQ------TVTFAELFAASKRMAEQLA-AHSVRK 54 Query: 189 GDTVAVYMPMVPEAIITLLAISRIGAIHSVVFAGFSSNSLRDRINDGDSKVVITTD--ES 246 GDT A+ + E + + A +G ++ S++ ++ D S ++T E Sbjct: 55 GDTAAILLQNRAEMVYAVHACFLLGVKAVLLNTKLSTHERLFQLEDSGSGFLLTDSSFEK 114 Query: 247 NRGGKVIETKRIVDDALRETPGVRHVLVYRKTNNPSVAFHAPRDLDWATEKKKYKTYYPC 306 +++T VD+ ++E + Y + + + Sbjct: 115 KEYEHIVQTID-VDELMKEAAEEIEIEAYMQMDATAT----------------------- 150 Query: 307 TPVDSEDPLFLLYTSGSTGAPKGVQHSTAGYLLGALLTMRYTFDTHQEDVFFTAGDIGWI 366 L+YTSG+TG PKGVQ + + A+ + ++D + A + I Sbjct: 151 ----------LMYTSGTTGKPKGVQQTFGNHYFSAV-SSALNLGITEQDRWLIALPLFHI 199 Query: 367 TGHTYVVYGPLLYGCATLVFEGTPAYPNYSRYWDIIDEHKVTQFYVAPTAL-RLLKRAGD 425 +G + ++ ++YG ++ + + S I+ H+VT T L LL+ Sbjct: 200 SGLS-ALFKSVIYGMTVVLHQRF----SVSDVLHSINRHEVTMISAVQTMLASLLEET-- 252 Query: 426 SYIENHSLKSLRCLGSVGEPIAAEVWEWYSEKIGKNEIPIVDTYWQTESGSHLVTPLAGG 485 N +S+RC+ G P + E EK P+ +Y TE+ S +VT L+ Sbjct: 253 ----NRCPESIRCILLGGGPAPLPLLEECREK----GFPVFQSYGMTETCSQIVT-LSPE 303 Query: 486 VTPMKPGSASFPFFGI------DAVVLDPNTGEELNTSHAEGVLAVKAAWPSFARTIWKN 539 + K GSA P F D V +P + G + VK P+ ++ + Sbjct: 304 FSMEKLGSAGKPLFSCEIKIERDGQVCEP---------YEHGEIMVKG--PNVMKSYFNR 352 Query: 540 HDRYLDTYLNPYPGYYFTGDGAAKDKDGYIWILGRVDDVVNVSGHRLSTAEIEAAIIEDP 599 ++ N G+ TGD D +G++++L R D++ G + AE+E+ ++ P Sbjct: 353 ESANEASFQN---GWLKTGDLGYLDNEGFLYVLDRRSDLIISGGENIYPAEVESVLLSHP 409 Query: 600 IVAECAVVGFNDDLTGQAVAAFVVLKNKSSWSTATDDELQDIKKHLVFTVRKDIGPFAAP 659 VAE V G D G+ A++VL S TD ++ + + P Sbjct: 410 AVAEAGVSGAEDKKWGKVPHAYLVLHKPVSAGELTD------------YCKERLAKYKIP 457 Query: 660 KLIILVDDLPKTRSGKIMRRILRKILAGE 688 ++D LP+ S K++R L+ GE Sbjct: 458 AKFFVLDRLPRNASNKLLRNQLKDARKGE 486 >2V7B-A nrPDB Length = 529 Score = 108 bits (271), Expect = 6e-24, Method: Compositional matrix adjust. Identities = 112/376 (29%), Positives = 171/376 (45%), Gaps = 32/376 (8%) Query: 311 SEDPLFLLYTSGSTGAPKGVQHSTAGYLLGALLTMRYTFDTHQEDVFFTAGDIGWITGHT 370 +D F LY+SGSTG PKG H+ A A L + + DV F+A + + G Sbjct: 182 CDDIAFWLYSSGSTGKPKGTVHTHANLYWTAELYAKPILGIAENDVVFSAAKLFFAYGLG 241 Query: 371 YVVYGPLLYGC-ATLVFEGTPAYPNYSRYWDIIDEHKVTQFYVAPTALRLLKRAGDSYIE 429 + PL G A L+ E A ++R + EH+ T FY PT + + + + Sbjct: 242 NGLTFPLSVGATAILMAERPTADAIFAR----LVEHRPTVFYGVPTLYANMLVSPN--LP 295 Query: 430 NHSLKSLRCLGSVGEPIAAEVWEWYSEKIGKNEIPIVDTYWQTESGSHLVTPLAGGVTPM 489 + ++R S GE + E+ E ++ G I+D TE ++ AG V Sbjct: 296 ARADVAIRICTSAGEALPREIGERFTAHFGCE---ILDGIGSTEMLHIFLSNRAGAV--- 349 Query: 490 KPGSASFPFFGIDAVVLDPNTGEELNTSHAEGVLAVKAAWPSFARTIWKNHDRYLDTYLN 549 + G+ P G + + L G + G L +K PS A W N ++ T+L Sbjct: 350 EYGTTGRPVPGYE-IELRDEAGHAVPDGEV-GDLYIKG--PSAAVMYWNNREKSRATFLG 405 Query: 550 PYPGYYFTGDGAAKDKDGYIWILGRVDDVVNVSGHRLSTAEIEAAIIEDPIVAECAVVGF 609 + +GD + +G GR DD++ VSG +S E+E +++ V E AVVG Sbjct: 406 E---WIRSGDKYCRLPNGCYVYAGRSDDMLKVSGQYVSPVEVEMVLVQHDAVLEAAVVGV 462 Query: 610 NDDLTGQAVA--AFVVLKNKSSWSTATDDELQDIKKHLVFTVRKDIGPFAAPKLIILVDD 667 + G V AFVVLK + + S +EL+ V+ + P P+ I+ VDD Sbjct: 463 DH---GGLVKTRAFVVLKREFAPSEILAEELKAF-------VKDRLAPHKYPRDIVFVDD 512 Query: 668 LPKTRSGKIMRRILRK 683 LPKT +GKI R LR+ Sbjct: 513 LPKTATGKIQRFKLRE 528 >3TSY-A nrPDB Length = 979 Score = 103 bits (257), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 130/549 (23%), Positives = 227/549 (41%), Gaps = 76/549 (13%) Query: 161 GYSITYKELLEEVCQVAQVLTYSMGVRKGDTVAVYMPMVPEAIITLLAISRIGAIHSVVF 220 G+ TY ++ Q+A + +GV + D V + +P PE +++ LA S GA + Sbjct: 86 GHVYTYSDVHVISRQIAANF-HKLGVNQNDVVMLLLPNCPEFVLSFLAASFRGATATAAN 144 Query: 221 AGFSSNSLRDRINDGDSKVVITTDESNRGGKVIETKRIVDDA--LRETPGVRHVLVYRKT 278 F+ + + ++K++IT R VD L+ GV V + Sbjct: 145 PFFTPAEIAKQAKASNTKLIITE------------ARYVDKIKPLQNDDGVVIVCIDDNE 192 Query: 279 NNPSVAFHAPRDLDWATEKKKYKTYYPCTPVDSEDPLFLLYTSGSTGAPKGVQHSTAGYL 338 + P + R + + + +D + L Y+SG+TG PKGV + G + Sbjct: 193 SVP-IPEGCLRFTELTQSTTEASEVIDSVEISPDDVVALPYSSGTTGLPKGVMLTHKGLV 251 Query: 339 LGALLTMRYTFDTHQEDVFFTAGDIGWIT---GHTYVVYGPLLYGCATLVFEGTPAYPNY 395 ++ D +++F + D+ H Y + +L C V P + Sbjct: 252 T----SVAQQVDGENPNLYFHSDDVILCVLPMFHIYALNSIML--CGLRVGAAILIMPKF 305 Query: 396 --SRYWDIIDEHKVTQFYVAPTALRLLKRAGDSYIENHSLKSLRCLGSVGEPIAAEVWEW 453 + ++I KVT + P + L A S E + L S+R + S P+ E+ + Sbjct: 306 EINLLLELIQRCKVTVAPMVPPIV--LAIAKSSETEKYDLSSIRVVKSGAAPLGKELEDA 363 Query: 454 YSEKIGKNEIPIVDTYWQTESGSHLVTPL--AGGVTPMKPGSASFPFFGIDAVVLDPNTG 511 + K ++ Y TE+G L L A P+K G+ + ++DP+TG Sbjct: 364 VNAKFPNAKLG--QGYGMTEAGPVLAMSLGFAKEPFPVKSGACGTVVRNAEMKIVDPDTG 421 Query: 512 EELNTSHAEGVLAVKAAWPSFARTIWKNHDRYLDTYLNPYPGYYFTGDGAAKDKDGYI-- 569 + L+ + G + ++ I K YL+ NP DKDG++ Sbjct: 422 DSLSRNQP-GEICIRG------HQIMKG---YLN---NP------AATAETIDKDGWLHT 462 Query: 570 ------------WILGRVDDVVNVSGHRLSTAEIEAAIIEDPIVAECAVVGFNDDLTGQA 617 +I+ R+ +++ G +++ AE+EA +I P + + AVV ++ G+ Sbjct: 463 GDIGLIDDDDELFIVDRLKELIKYKGFQVAPAELEALLIGHPDITDVAVVAMKEEAAGEV 522 Query: 618 VAAFVVLKNKSSWSTATDDELQDIKKHLVFTVRKDIGPFAAPKLIILVDDLPKTRSGKIM 677 AFVV S S DD Q + K +VF R + + + +PK SGKI+ Sbjct: 523 PVAFVVKSKDSELS--EDDVKQFVSKQVVFYKRIN--------KVFFTESIPKAPSGKIL 572 Query: 678 RRILRKILA 686 R+ LR LA Sbjct: 573 RKDLRAKLA 581 >4GR5-A nrPDB Length = 570 Score = 100 bits (248), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 130/563 (23%), Positives = 229/563 (40%), Gaps = 84/563 (14%) Query: 132 NAC-YNCVDRHALKTPNKKAIIFEGDEPGQGYSITYKELLEEVCQVAQVLTYSMGVRKGD 190 AC + + A + P+ A++ E DE +TY L E ++A L +GV G Sbjct: 74 GACVHELFEAQAARAPDAVALLHEADE------LTYGALNERANRLAHRLV-GLGVAPGT 126 Query: 191 TVAVYMPMVPEAIITLLAISRIGAIHSVVFAGFSSNSLRDRINDGDSKVVITTDESNRGG 250 V V++ + ++ LLA+ + G ++++ F L + D + +++T+ + Sbjct: 127 LVGVHLERGFDMVVALLAVLKAGGGYTMLDPQFPVERLALSLEDTGAPLLVTSRPLSGRL 186 Query: 251 KVIETKRIVDDALRETPGVRHVLVYRKTNNPSVAFHAPRDLDWATEKKKYKTYYPCTPVD 310 T + D+A + P N + T V Sbjct: 187 TGTTTLYVEDEAASDAP----------AGNLA------------------------TGVG 212 Query: 311 SEDPLFLLYTSGSTGAPKGVQHSTAGYLLGALLTMRYTFDTHQEDVFFTAGDIGWITGHT 370 ED +++TSGSTG PKGV S L G L Y ++VF + W Sbjct: 213 PEDVACVMFTSGSTGRPKGVM-SPHRALTGTYLGQDYA-GFGPDEVFLQCSPVSW-DAFG 269 Query: 371 YVVYGPLLYGCATLVFEGTPAYPNYSRYWDIIDEHKVTQFYVAPTALRLLKRAGDSYIEN 430 ++G LL+G ++ G P+ +++ H VT ++ + L D E Sbjct: 270 LELFGALLFGARCVLQSGQ--NPDPLEIGELVARHGVTMLQLSASLFNFLV---DEVPE- 323 Query: 431 HSLKSLRCLGSVGEP-----IAAEVWEWYSEKIGKNEIPIVDTYWQTESGSHLVTP--LA 483 + + +R + GEP +A + + ++G P + T H V L+ Sbjct: 324 -AFEGVRYAITGGEPASVPHVAKARRDHPALRLGNGYGPAESMGFTTH---HAVVAGDLS 379 Query: 484 GGVTPMKPGSASFPFFGIDAVVLDPNTGEELNTSHAEGVLAVKAAWPSFARTIWKNHDRY 543 G P+ P G A VLD + N + E +A + +R+ Sbjct: 380 GTALPI-----GVPLAGKRAYVLDDDLKPAANGALGELYVAGAGLAHGYVSRPALTAERF 434 Query: 544 LDTYLNPYPG-----YYFTGDGAAKDKDGYIWILGRVDDVVNVSGHRLSTAEIEAAIIED 598 + +P+ G Y TGD A + DG + +GR DD V + G R+ E+EA ++ Sbjct: 435 V---ADPFAGPGGERMYRTGDLARRRADGVLEYVGRADDQVKIRGFRVEPGEVEARLVGH 491 Query: 599 PIVAECAVVGFNDDLTGQAVAAFVVLKNKSSWSTATDDELQDIKKHLVFTVRKDIGPFAA 658 P V + AV+ + L + + A+VV + + A ++++H V + + + Sbjct: 492 PAVRQAAVLAQDSRLGDKQLVAYVVAERADAPPDAA-----ELRRH----VAEALPAYMV 542 Query: 659 PKLIILVDDLPKTRSGKIMRRIL 681 P + VD+LP+T +GK+ RR L Sbjct: 543 PVECVPVDELPRTPNGKLDRRAL 565 >4M46-A nrPDB Length = 581 Score = 89.4 bits (220), Expect = 5e-18, Method: Compositional matrix adjust. Identities = 101/384 (26%), Positives = 176/384 (45%), Gaps = 52/384 (13%) Query: 316 FLLYTSGSTGAPKGVQHSTAGYLLGALLTMRYTFDTHQEDVFF---TAGDIGWIT----G 368 ++ +SGSTG PKGV+ L + +R++ H D F D +T Sbjct: 228 LIMNSSGSTGLPKGVE------LTHKNICVRFS---HCRDPVFGNQIIPDTAILTVIPFH 278 Query: 369 HTYVVYGPLLYGCATLVFEGTPAYP-NYSRYWDIIDEHKVTQFYVAPTALRLLKRAGDSY 427 H + ++ L G T F Y + + ++K+ + PT ++ + Sbjct: 279 HGFGMFTTL--GYLTCGFRIVLMYRFEEELFLRSLQDYKIQSALLVPTLFSFFAKS--TL 334 Query: 428 IENHSLKSLRCLGSVGEPIAAEVWEWYSEKIGKNEIP-IVDTYWQTESGSHLVTPLAGGV 486 ++ + L +L + S G P+A EV E +++ ++P I Y TE+ S ++ + Sbjct: 335 VDKYDLSNLHEIASGGAPLAKEVGEAVAKRF---KLPGIRQGYGLTETTSAII------I 385 Query: 487 TPM---KPGSAS--FPFFGIDAVVLDPNTGEELNTSHAEGVLAVKAAWPSFARTIWKNHD 541 TP KPG+ PFF A ++D +TG+ L + G L VK P + N + Sbjct: 386 TPEGDDKPGACGKVVPFF--SAKIVDLDTGKTLGVNQ-RGELCVKG--PMIMKGYVNNPE 440 Query: 542 RYLDTYLNPYPGYYFTGDGAAKDKDGYIWILGRVDDVVNVSGHRLSTAEIEAAIIEDPIV 601 + L G+ +GD A DKDG+ +I+ R+ ++ G+++ AE+E+ +++ P + Sbjct: 441 A--TSALIDKDGWLHSGDIAYYDKDGHFFIVDRLKSLIKYKGYQVPPAELESILLQHPFI 498 Query: 602 AECAVVGFNDDLTGQAVAAFVVLKNKSSWSTATDDELQDIKKHLVFTVRKDIGPFAAPKL 661 + V G D G+ AA VVL+ T T+ E+ D V ++ G Sbjct: 499 FDAGVAGIPDPDAGELPAAVVVLEE---GKTMTEQEVMDYVAGQVTASKRLRGG------ 549 Query: 662 IILVDDLPKTRSGKIMRRILRKIL 685 + VD++PK +GKI R +R+IL Sbjct: 550 VKFVDEVPKGLTGKIDARKIREIL 573 >5DWV-A nrPDB Length = 573 Score = 88.6 bits (218), Expect = 8e-18, Method: Compositional matrix adjust. Identities = 100/383 (26%), Positives = 178/383 (46%), Gaps = 50/383 (13%) Query: 316 FLLYTSGSTGAPKGVQ--HSTA----GYLLGALLTMRYTFDTHQEDVFFTAGDIGWITGH 369 ++ +SGSTG PKGV H TA + + + DT V G T Sbjct: 217 LIMNSSGSTGLPKGVALPHRTACVRFSHARDPIFGNQIIPDTAILSVVPFHHGFGMFTTL 276 Query: 370 TYVVYG---PLLYGCATLVFEGTPAYPNYSRYWDIIDEHKVTQFYVAPTALRLLKRAGDS 426 Y++ G L+Y +F + + ++K+ + PT ++ + Sbjct: 277 GYLICGFRVVLMYRFEEELFLRS------------LQDYKIQSALLVPTLFSFFAKS--T 322 Query: 427 YIENHSLKSLRCLGSVGEPIAAEVWEWYSEKIGKNEIP-IVDTYWQTESGSH-LVTPLAG 484 I+ + L +L + S G P++ EV E +++ +P I Y TE+ S L+TP Sbjct: 323 LIDKYDLSNLHEIASGGAPLSKEVGEAVAKRF---HLPGIRQGYGLTETTSAILITPEGD 379 Query: 485 GVTPMKPGSAS--FPFFGIDAVVLDPNTGEELNTSHAEGVLAVKAAWPSFARTIWKNHDR 542 KPG+ PFF +A V+D +TG+ L + G L V+ + + N+ Sbjct: 380 D----KPGAVGKVVPFF--EAKVVDLDTGKTLGVNQ-RGELCVRGPM---IMSGYVNNPE 429 Query: 543 YLDTYLNPYPGYYFTGDGAAKDKDGYIWILGRVDDVVNVSGHRLSTAEIEAAIIEDPIVA 602 + ++ G+ +GD A D+D + +I+ R+ ++ G++++ AE+E+ +++ P + Sbjct: 430 ATNALIDK-DGWLHSGDIAYWDEDEHFFIVDRLKSLIKYKGYQVAPAELESILLQHPNIF 488 Query: 603 ECAVVGFNDDLTGQAVAAFVVLKNKSSWSTATDDELQDIKKHLVFTVRKDIGPFAAPKLI 662 + V G DD G+ AA VVL++ T T+ E+ D V T +K G + Sbjct: 489 DAGVAGLPDDDAGELPAAVVVLEH---GKTMTEKEIVDYVASQVTTAKKLRGG------V 539 Query: 663 ILVDDLPKTRSGKIMRRILRKIL 685 + VD++PK +GK+ R +R+IL Sbjct: 540 VFVDEVPKGLTGKLDARKIREIL 562 >3O84-A nrPDB Length = 544 Score = 87.0 bits (214), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 120/516 (23%), Positives = 208/516 (40%), Gaps = 68/516 (13%) Query: 185 GVRKGDTVAVYMPMVPEAIITLLAISRIGAIHSVVFAGFSSNSLRDRINDGDSKVVITTD 244 G+ KGDT V +P V E I A+ + G + L I K++I Sbjct: 76 GLGKGDTALVQLPNVAEFYIVFFALLKAGVVVLNALYSHRQYELNAFIKQIQPKLLI--- 132 Query: 245 ESNRGGKVIETKRIVDDA--LRETPGVRHVLVYRKTNNPSVAFHAPRDLDWATEKKKYKT 302 +R +V + +D + +P + +L ++ T+ F LDW + Sbjct: 133 -GSRQHEVFSNNQFIDSLHDVNLSPEIILMLNHQATD-----FGL---LDWIETPAETFV 183 Query: 303 YYPCTPVDSEDPLFLLYTSGSTGAPKGVQHSTAGYLLGALLTMRYTFDTHQEDVFFTAGD 362 + TP D + F + GSTG PK + + Y Y+ E + Sbjct: 184 DFSSTPAD--EVAFFQLSGGSTGTPKLIPRTHNDY--------DYSVRASAEICGLNSNT 233 Query: 363 ---IGWITGHTYVVYGP----LLYGCATLVFEGTPAYPNYSRYWDIIDEHKVTQFYVAPT 415 H +++ P +L+ +V P N + II H+V + P+ Sbjct: 234 RLLCALPAPHNFMLSSPGALGVLHAGGCVVMAPNPEPLNC---FSIIQRHQVNMASLVPS 290 Query: 416 ALRL-LKRAGDSYIENHSLKSLRCLG-SVGEPIAAEVWEWYSEKI----GKNEIPIVDTY 469 A+ + L++A + SLK L+ G S E +A +V E + K+ G E +V+ Sbjct: 291 AVIMWLEKAAQYKDQIQSLKLLQVGGASFPESLARQVPEVLNCKLQQVFGMAE-GLVNYT 349 Query: 470 WQTESGSHLVTPLAGGVTPMKPGSASFPFFGIDAVVLDPNTGEELNTSHAEGVLAVKAAW 529 +S + T T +P S+ +D + GE G+LA + + Sbjct: 350 RLDDSDEQIFT------TQGRPISSDDEIKIVDEQYREVPEGEI-------GMLATRGPY 396 Query: 530 PSFARTIWKNHDRYLDTYLNPYPGYYFTGDGAAKDKDGYIWILGRVDDVVNVSGHRLSTA 589 H+ + N YY++GD + DG + ++GR+ D +N G ++++ Sbjct: 397 TFCGYYQSPEHNSQVFDEDN----YYYSGDLVQRTPDGNLRVVGRIKDQINRGGEKIASE 452 Query: 590 EIEAAIIEDPIVAECAVVGFNDDLTGQAVAAFVVLKNKSSWSTATDDELQDIKKHLVFTV 649 EIE I+ P V A+V D+ G+ AF+V +N + +++HL + Sbjct: 453 EIEKLILLHPEVMHAALVAIVDEQFGEKSCAFIVSRNPELKAVV-------LRRHL---M 502 Query: 650 RKDIGPFAAPKLIILVDDLPKTRSGKIMRRILRKIL 685 I + P I L++ LP T GK+ ++ LR IL Sbjct: 503 ELGIAQYKLPDQIKLIESLPLTAVGKVDKKQLRSIL 538 >3RG2-A nrPDB Length = 617 Score = 84.3 bits (207), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 125/559 (22%), Positives = 226/559 (40%), Gaps = 69/559 (12%) Query: 164 ITYKELLEEVCQVAQVLTYSMGVRKGDTVAVYMPMVPEAIITLLAISRIGAIHSVVFAGF 223 ++Y+EL + +A L G++ G+T V + V E IT A+ ++G + V A F Sbjct: 51 LSYRELNQAADNLACSLR-RQGIKPGETALVQLGNVAELYITFFALLKLGV--APVLALF 107 Query: 224 SSNSLRDRINDGDSKVVITTDESNRGGKVIETKRIVDDALRETPGVRHVLVYRKT--NNP 281 S R +N S++ ++R + ++ + E +R V + + +N Sbjct: 108 SHQ--RSELNAYASQIEPALLIADRQHALFSGDDFLNTFVTEHSSIRVVQLLNDSGEHNL 165 Query: 282 SVAFHAPRDLDWATEKKKYKTYYPCTPVDSEDPLFLLYTSGSTGAPKGVQHSTAGYLLGA 341 A + P + + TP +++ + + G+TG PK + + Y Sbjct: 166 QDAINHPAE------------DFTATPSPADEVAYFQLSGGTTGTPKLIPRTHNDYYYSV 213 Query: 342 LLTMRYTFDTHQEDVFFTAGDIGWITGHTYVVYGP----LLYGCATLVFEGTPAYPNYSR 397 ++ T Q H Y + P + T+V A P+ + Sbjct: 214 RRSVEICQFTQQTRYLCAIP-----AAHNYAMSSPGSLGVFLAGGTVVLA---ADPSATL 265 Query: 398 YWDIIDEHKVTQFYVAPTALRLLKRA---GDSYIENHSLKSLRCLG-----SVGEPIAAE 449 + +I++H+V + P A+ L +A G+S + SLK L+ G ++ I AE Sbjct: 266 CFPLIEKHQVNVTALVPPAVSLWLQALIEGESRAQLASLKLLQVGGARLSATLAARIPAE 325 Query: 450 VWEWYSEKIGKNEIPIVDTYWQTESGSHLVTPLAGGVTPMKPGSASFPFFGIDAVVLDPN 509 + + G E + Y + + + + G PM P D V + Sbjct: 326 IGCQLQQVFGMAEGLV--NYTRLDDSAEKIIHTQG--YPMCPD---------DEVWVADA 372 Query: 510 TGEELNTSHAEGVLAVKAAWPSFARTIWKNHDRYLDTYLNPYPGYYFTGDGAAKDKDGYI 569 G L G L + P R +K+ + G+Y +GD + D +GYI Sbjct: 373 EGNPLPQGEV-GRLMTRG--PYTFRGYYKSPQHNASAF--DANGFYCSGDLISIDPEGYI 427 Query: 570 WILGRVDDVVNVSGHRLSTAEIEAAIIEDPIVAECAVVGFNDDLTGQAVAAFVVLKNKSS 629 + GR D +N G +++ EIE ++ P V A+V D+L G+ A++V+K Sbjct: 428 TVQGREKDQINRGGEKIAAEEIENLLLRHPAVIYAALVSMEDELMGEKSCAYLVVK---- 483 Query: 630 WSTATDDELQDIKKHLVFTVRKDIGPFAAPKLIILVDDLPKTRSGKIMRRILRKILAGES 689 + L+ ++ F + I F P + VD LP T GK+ ++ LR+ LA + Sbjct: 484 ------EPLRAVQVRR-FLREQGIAEFKLPDRVECVDSLPLTAVGKVDKKQLRQWLASRA 536 Query: 690 DQLGDVSTLSNPGIVRHLI 708 G S ++ +R +I Sbjct: 537 SA-GRASIPASKAALREVI 554 >3IVR-A nrPDB Length = 509 Score = 81.6 bits (200), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 128/552 (23%), Positives = 215/552 (38%), Gaps = 78/552 (14%) Query: 140 RHALKTPNKKAIIFEGDEPGQGYSITYKELLEEVCQVAQVLTYSMGVRKGDTVAVYMPMV 199 R+A P++ A + +G +T+++ L ++A L GV GD VA+ Sbjct: 14 RNAALFPDRTAFMVDG------VRLTHRDYLARAERLASGLLRD-GVHTGDRVAILSQNC 66 Query: 200 PEAIITLLAISRIGAIHSVVFAGFSSNSLRDRINDGDSKVVITTDESNRGGKVIETKRIV 259 E I + A++ IGAI V +++ + + DG VV+ + + IV Sbjct: 67 SEMIELIGAVALIGAILLPVNYRLNADEIAFVLGDGAPSVVVAG---------TDYRDIV 117 Query: 260 DDALRETPGVRHVLVYRKTNNPSVAFHAPRDLDWATEKKKYKTYYPCTPVDSEDPLFLLY 319 L GV+ + P F D A++ T + + D +++ Sbjct: 118 AGVLPSLGGVKKAYAIGDGSGPFAPFK-----DLASD-----TPFSAPEFGAADGFVIIH 167 Query: 320 TSGSTGAPKGVQHSTAGYLLGALLTMRYTFDTHQEDVFFTAGDIGWITGHTYVVYGPLLY 379 T+ G P+G S G LL A ++ + + DV + +TG ++ Sbjct: 168 TAAVGGRPRGALISQ-GNLLIAQSSLVDAWRLTEADVNLGMLPLFHVTGLGLMLTLQQAG 226 Query: 380 GCATLVFEGTPAYPNYSRYWDIIDEHKVTQFY-VAPTALRLLKRAGDSYIENHSLKSLRC 438 G + + + PA I+ HKVT AP +L +A + L SLR Sbjct: 227 GASVIAAKFDPAQAARD-----IEAHKVTVMAEFAPMLGNILDQAAPA-----QLASLRA 276 Query: 439 LGSVGEPIAAEVWEWYSEKIGKNEIPIVDTYWQT-----ESGSHLVTPLAGGVTPMKPGS 493 + + P E +E T+W T SG P +P S Sbjct: 277 VTGLDTPETIERFEATCPNA---------TFWATFGQSETSGLSTFAPYRD-----RPKS 322 Query: 494 ASFPFFGIDAVVLDPNTGEELNTSHAE-GVLAVKAAWPSFARTIWKNHDRYLDTYLNPYP 552 A P F V+D E+ E G + ++ P+ + W N + N Sbjct: 323 AGRPLFWRTVAVVD---AEDRPLPPGEVGEIVLRG--PTVFKGYWNNAAATQHAFRN--- 374 Query: 553 GYYFTGDGAAKDKDGYIWILGRV--DDVVNVSGHRLSTAEIEAAIIEDPIVAECAVVGFN 610 G++ TGD D DGY++ GR +++ G + AE+E A+ + P +A+ V+G Sbjct: 375 GWHHTGDMGRFDADGYLFYAGRAPEKELIKTGGENVYPAEVEGALKQHPAIADAVVIGVP 434 Query: 611 DDLTGQAVAAFVVLKNKSSWSTATDDELQDIKKHLVFTVRKDIGPFAAPKLIILVDDLPK 670 D +A+ A V K S + D L + L+ +K PK ++ V+ LPK Sbjct: 435 DPQWSEAIKAVCVCKPGESIAA---DALAEFVASLIARYKK-------PKHVVFVEALPK 484 Query: 671 TRSGKIMRRILR 682 G I R ++ Sbjct: 485 DAKGAIDRAAVK 496 >2D1S-A nrPDB Length = 548 Score = 75.9 bits (185), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 96/387 (24%), Positives = 170/387 (43%), Gaps = 50/387 (12%) Query: 312 EDPLFLLYTSGSTGAPKGVQHSTAGYLLGALLTMRYTFDTHQEDVFF-------TAGDIG 364 E ++ +SGSTG PKGVQ L + R++ H D + TA Sbjct: 192 EQVALIMNSSGSTGLPKGVQ------LTHENIVTRFS---HARDPIYGNQVSPGTAVLTV 242 Query: 365 WITGHTYVVYGPLLYG-CATLVFEGTPAYPNYSRYWDIIDEHKVTQFYVAPTALRLLKRA 423 H + ++ L Y C V T + + + ++K T + PT +L ++ Sbjct: 243 VPFHHGFGMFTTLGYLICGFRVVMLTKF--DEETFLKTLQDYKCTSVILVPTLFAILNKS 300 Query: 424 GDSYIENHSLKSLRCLGSVGEPIAAEVWEWYSEKIGKNEIPIVDTYWQTESGSHLVTPLA 483 + + L +L + S G P++ EV E + + N + Y TE+ S ++ Sbjct: 301 --ELLNKYDLSNLVEIASGGAPLSKEVGEAVARRF--NLPGVRQGYGLTETTSAII---- 352 Query: 484 GGVTPM---KPGSAS--FPFFGIDAVVLDPNTGEELNTSHAEGVLAVKAAWPSFARTIWK 538 +TP KPG++ P F A V+D +T + L + G + VK P + Sbjct: 353 --ITPEGDDKPGASGKVVPLF--KAKVIDLDTKKSLGPNR-RGEVCVKG--PMLMKGYVN 405 Query: 539 NHDRYLDTYLNPYPGYYFTGDGAAKDKDGYIWILGRVDDVVNVSGHRLSTAEIEAAIIED 598 N + + L G+ TGD D++ + +I+ R+ ++ G+++ AE+E+ +++ Sbjct: 406 NPEATKE--LIDEEGWLHTGDIGYYDEEKHFFIVDRLKSLIKYKGYQVPPAELESVLLQH 463 Query: 599 PIVAECAVVGFNDDLTGQAVAAFVVLKNKSSWSTATDDELQDIKKHLVFTVRKDIGPFAA 658 P + + V G D + G+ A VVL+ S T+ E+ D V ++ G Sbjct: 464 PSIFDAGVAGVPDPVAGELPGAVVVLE---SGKNMTEKEVMDYVASQVSNAKRLRGG--- 517 Query: 659 PKLIILVDDLPKTRSGKIMRRILRKIL 685 + VD++PK +GKI R +R+IL Sbjct: 518 ---VRFVDEVPKGLTGKIDGRAIREIL 541 >1MDF-A nrPDB Length = 539 Score = 74.7 bits (182), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 118/538 (21%), Positives = 209/538 (38%), Gaps = 68/538 (12%) Query: 165 TYKELLEEVCQVAQVLTYSMGVRKGDTVAVYMPMVPEAIITLLAISRIGAIHSVVFAGFS 224 +Y+EL ++A +G+++ D V V +P + E + A+ R+GA+ Sbjct: 52 SYRELDTRADRLAAGFQ-KLGIQQKDRVVVQLPNIKEFFEVIFALFRLGALPVFALPSHR 110 Query: 225 SNSLRDRINDGDSKVVITTDESNRGGKVIETKRIVDDALRETPGVRHVLVYRKTNNPSVA 284 S+ + ++ I D + G R V L P +++++V + Sbjct: 111 SSEITYFCEFAEAAAYIIPD-AYSGFDYRSLARQVQSKL---PTLKNIIVAGEAEE---- 162 Query: 285 FHAPRDLDWATEKKKYKTYYPCTPVDSEDPLFLLYTSGSTGAPKGVQHSTAGYLLGALLT 344 F DL TE K V S D FL + GSTG K + + Y+ + Sbjct: 163 FLPLEDLH--TEPVKLPE------VKSSDVAFLQLSGGSTGLSKLIPRTHDDYIYSLKRS 214 Query: 345 MRYTFDTHQEDVFFTAGDIGWITGHTYVVYGP----LLYGCATLVFEGTPAYPNYSRYWD 400 + + H V+ A + H Y + P +LY +V +P+ P+ + + Sbjct: 215 VEVCWLDHST-VYLAALPMA----HNYPLSSPGVLGVLYAGGRVVLSPSPS-PDDA--FP 266 Query: 401 IIDEHKVTQFYVAPTALRLLKRAGDSYIENHSLKSLRCLGSVGEPIAAEVWEWYSEKIGK 460 +I+ KVT + P + A S ++ L SL+ L G +AE G Sbjct: 267 LIEREKVTITALVPPLAMVWMDAASSRRDD--LSSLQVLQVGGAKFSAEAARRVKAVFGC 324 Query: 461 NEIPIVD------TYWQTESGSHLVTPLAGGVTPMKPGSASFPFFGIDAVVLDPNTGEEL 514 + Y + + ++ G PM P S + D V TG L Sbjct: 325 TLQQVFGMAEGLVNYTRLDDPEEIIVNTQG--KPMSPYDESRVWDDHDRDVKPGETGHLL 382 Query: 515 NTSHAEGVLAVKAAWPSFARTIWKNHDRYLDTYLNPYPGYYFTGDGAAKDKDGYIWILGR 574 P R +K + ++ G+Y TGD +DGYI + GR Sbjct: 383 TRG------------PYTIRGYYKAEEHNAASFTED--GFYRTGDIVRLTRDGYIVVEGR 428 Query: 575 VDDVVNVSGHRLSTAEIEAAIIEDPIVAECAVVGFNDDLTGQAVAAFVVLKNKSSWSTAT 634 D +N G +++ E+E ++ P V + A+V D G+ F++ ++++ + Sbjct: 429 AKDQINRGGEKVAAEEVENHLLAHPAVHDAAMVSMPDQFLGERSCVFIIPRDEAPKAA-- 486 Query: 635 DDELQDIKKHLVFTVRKDIGPFAAPKLIILVDDLPKTRSGKIMRRILR-----KILAG 687 EL+ F + + + P + V+ P+T GK+ ++ LR K+LAG Sbjct: 487 --ELK------AFLRERGLAAYKIPDRVEFVESFPQTGVGKVSKKALREAISEKLLAG 536 >3IPL-A nrPDB Length = 501 Score = 72.4 bits (176), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 115/554 (20%), Positives = 206/554 (37%), Gaps = 119/554 (21%) Query: 163 SITYKELLEEVCQVAQVLTYSMGVRKGDTVAVYMPMVPEAIITLLAISRIGAIHSVVFAG 222 S TY+ L E A +L + + V +Y+ ++II + A +++ Sbjct: 26 SYTYQNLYCE----ASLLAKRLKAYQQSRVGLYIDNSIQSIILIHACWLANIEIAMINTR 81 Query: 223 FSSNSLRDRINDGDSKVVITT-------------DESNRGGKVIETKRIVDDALRETPGV 269 + N + +++ D +++ T D+ G+ I T ++D+ T G+ Sbjct: 82 LTPNEMTNQMRSIDVQLIFCTLPLELRGFQIVSLDDIEFAGRDITTNGLLDN----TMGI 137 Query: 270 RHVLVYRKTNNPSVAFHAPRDLDWATEKKKYKTYYPCTPVDSEDPLFLLYTSGSTGAPKG 329 + Y +N V +P ++ T + +D +++TSG+TG K Sbjct: 138 Q----YDTSNETVVPKESPSNI-------------LNTSFNLDDIASIMFTSGTTGPQKA 180 Query: 330 VQHSTAGYLLGALLTMRYTFDTHQEDVFFTAGDIGWITGHTYVVYGPLLY--GCATL--- 384 V TF H +G+ ++ P+ + G + L Sbjct: 181 VPQ---------------TFRNHYASAIGCKESLGFDRDTNWLSVLPIYHISGLSVLLRA 225 Query: 385 VFEGTPAYP----NYSRYWDIIDEHKVTQFYVAPTALRLLKRAGDSYIENHSLKSLRCLG 440 V EG N + +I ++T + P L L + G E ++L+ + G Sbjct: 226 VIEGFTVRIVDKFNAEQILTMIKNERITHISLVPQTLNWLMQQGLH--EPYNLQKILLGG 283 Query: 441 SVGEPIAAEVWEWYSEKIGKNEIPIVDTYWQTESGSHLVTPLAGGVTP----MKPGSASF 496 + E Y+ +PI +++ TE+ S +T TP +P + Sbjct: 284 AKLSATMIETALQYN-------LPIYNSFGMTETCSQFLT-----ATPEMLHARPDTVGM 331 Query: 497 PFFGIDAVVLDPNTGEELNTSHAEGVLAVKAAWPSFARTIWKNHDRYLDTYLNPYP---- 552 P +D + +PN G L +K A ++ YL P Sbjct: 332 PSANVDVKIKNPN-------KEGHGELMIKGA-------------NVMNGYLYPTDLTGT 371 Query: 553 ---GYYFTGDGAAKDKDGYIWILGRVDDVVNVSGHRLSTAEIEAAIIEDPIVAECAVVGF 609 GY+ TGD A D +GY+ I R D++ G + +IE + P +++ VG Sbjct: 372 FENGYFNTGDIAEIDHEGYVMIYDRRKDLIISGGENIYPYQIETVAKQFPGISDAVCVGH 431 Query: 610 NDDLTGQAVAAFVVLKNKSSWSTATDDELQDIKKHLVFTVRKDIGPFAAPKLIILVDDLP 669 DD GQ + V ++ S K L+ + K + + PK VD LP Sbjct: 432 PDDTWGQVPKLYFVSESDIS------------KAQLIAYLSKHLAKYKVPKHFEKVDTLP 479 Query: 670 KTRSGKIMRRILRK 683 T +GK+ R L + Sbjct: 480 YTSTGKLQRNKLYR 493 >5WMM-A nrPDB Length = 926 Score = 68.6 bits (166), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 88/335 (26%), Positives = 142/335 (42%), Gaps = 32/335 (9%) Query: 302 TYYPCTPVDSEDP-----LFLLYTSGSTGAPKGVQHSTAGYLLGALLTMRYTFDTHQEDV 356 T YP P+D+ D +L+YTSGSTG PKGV+ S L AL D + V Sbjct: 168 TGYPTRPLDTADVGGEHLAYLMYTSGSTGTPKGVEVSHRNVLSLALDPC--WADADHQRV 225 Query: 357 FFTAGDIGWITGHTYVVYGPLLYGCATLVFEGTPAYPNYSRYWDIIDEHKVTQFYVAPTA 416 A TY ++ PLL+G A +V P + +R +I E VT ++ Sbjct: 226 LVHAPPT--FDASTYEMWVPLLHGGAAVV--APPGKLDAARLATLIAERGVTALWLPAGL 281 Query: 417 LRLL-KRAGDSYIENHSLKSLRCLGSVGEPIAAEVWEWYSEKIGKNE--IPIVDTYWQTE 473 L+ + S+++ ++ + G V P A ++ +++ + +V+ Y TE Sbjct: 282 FDLITQHHPKSFVQ---VREVWAGGDVLSPAAVR-------RLVRDDGTLTVVNGYGPTE 331 Query: 474 S----GSHLVTPLAGGVTPMKPGSASFPFFGIDAVVLDPNTGEELNTSHAEGVLAVKAAW 529 + + ++ A P+ G P G LD + E + Sbjct: 332 TTTFAARYRMSAPARCKDPLPIGE---PMAGSRLYALDDRLRQVPQGVIGELYVGGDGVA 388 Query: 530 PSFARTIWKNHDRYL-DTYLNPYPGYYFTGDGAAKDKDGYIWILGRVDDVVNVSGHRLST 588 +A +R++ D + P Y TGD + DG + LGRVD+ V + G R+ Sbjct: 389 RGYANHPPLTSERFVADPFGRPGERMYRTGDLVRWNHDGQLEFLGRVDEQVKIRGFRVEP 448 Query: 589 AEIEAAIIEDPIVAECAVVGFNDDLTGQAVAAFVV 623 EI AA+ + VA+ VV D L + + A+VV Sbjct: 449 GEIRAALRKRDGVAQAVVVPRTDRLGERRLVAYVV 483 >1V25-A nrPDB Length = 541 Score = 58.2 bits (139), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 37/131 (28%), Positives = 68/131 (51%), Gaps = 10/131 (7%) Query: 553 GYYFTGDGAAKDKDGYIWILGRVDDVVNVSGHRLSTAEIEAAIIEDPIVAECAVVGFNDD 612 G++ TGD A D++GY+ I R+ D++ G +S+ ++E A++ P V E AVV Sbjct: 412 GFFRTGDIAVWDEEGYVEIKDRLKDLIKSGGEWISSVDLENALMGHPKVKEAAVVAIPHP 471 Query: 613 LTGQAVAAFVVLKNKSSWSTATDDELQDIKKHLVFTVRKDIGPFAAPKLIILVDDLPKTR 672 + A VV + + T +EL + HL ++ + P + +++P+T Sbjct: 472 KWQERPLAVVVPRGEKP----TPEELNE---HL---LKAGFAKWQLPDAYVFAEEIPRTS 521 Query: 673 SGKIMRRILRK 683 +GK ++R LR+ Sbjct: 522 AGKFLKRALRE 532 >4GR4-A nrPDB Length = 469 Score = 57.8 bits (138), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 101/458 (22%), Positives = 175/458 (38%), Gaps = 75/458 (16%) Query: 132 NAC-YNCVDRHALKTPNKKAIIFEGDEPGQGYSITYKELLEEVCQVAQVLTYSMGVRKGD 190 AC + + A + P+ A++ E DE +TY L E ++A L +GV G Sbjct: 74 GACVHELFEAQAARAPDAVALLHEADE------LTYGALNERANRLAHRLV-GLGVAPGT 126 Query: 191 TVAVYMPMVPEAIITLLAISRIGAIHSVVFAGFSSNSLRDRINDGDSKVVITTDESNRGG 250 V V++ + ++ LLA+ + G ++++ F L + D + +++T+ + Sbjct: 127 LVGVHLERGFDMVVALLAVLKAGGGYTMLDPQFPVERLALSLEDTGAPLLVTSRPLSGRL 186 Query: 251 KVIETKRIVDDALRETPGVRHVLVYRKTNNPSVAFHAPRDLDWATEKKKYKTYYPCTPVD 310 T + D+A + P N + T V Sbjct: 187 TGTTTLYVEDEAASDAP----------AGNLA------------------------TGVG 212 Query: 311 SEDPLFLLYTSGSTGAPKGVQHSTAGYLLGALLTMRYTFDTHQEDVFFTAGDIGWITGHT 370 ED +++TSGSTG PKGV S L G L Y ++VF + W Sbjct: 213 PEDVACVMFTSGSTGRPKGVM-SPHRALTGTYLGQDYA-GFGPDEVFLQCSPVSW-DAFG 269 Query: 371 YVVYGPLLYGCATLVFEGTPAYPNYSRYWDIIDEHKVTQFYVAPTALRLLKRAGDSYIEN 430 ++G LL+G ++ G P+ +++ H VT ++ + L D E Sbjct: 270 LELFGALLFGARCVLQSGQ--NPDPLEIGELVARHGVTMLQLSASLFNFLV---DEVPE- 323 Query: 431 HSLKSLRCLGSVGEP-----IAAEVWEWYSEKIGKNEIPIVDTYWQTESGSHLVTP--LA 483 + + +R + GEP +A + + ++G P + T H V L+ Sbjct: 324 -AFEGVRYAITGGEPASVPHVAKARRDHPALRLGNGYGPAESMGFTTH---HAVVAGDLS 379 Query: 484 GGVTPMKPGSASFPFFGIDAVVLDPNTGEELNTSHAEGVLAVKAAWPSFARTIWKNHDRY 543 G P+ P G A VLD + N + E +A + +R+ Sbjct: 380 GTALPI-----GVPLAGKRAYVLDDDLKPAANGALGELYVAGAGLAHGYVSRPALTAERF 434 Query: 544 LDTYLNPYPG-----YYFTGDGAAKDKDGYIWILGRVD 576 + +P+ G Y TGD A + DG + +GR D Sbjct: 435 V---ADPFAGPGGERMYRTGDLARRRADGVLEYVGRAD 469 >4LGC-A nrPDB Length = 539 Score = 52.0 bits (123), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 69/295 (23%), Positives = 118/295 (40%), Gaps = 40/295 (13%) Query: 400 DIIDEHKVTQFYVAPTAL-RLLKRAGDSYIENHSLKSLRCLGSVGEPIAAEVWEWYSEKI 458 ++I ++K+ + PT + RL K G + SLK+L G V P ++W + + Sbjct: 274 NMIKKYKIEFIQMVPTLMNRLAKLEGVGKEDFASLKALCHTGGVCSPWLKQIW---IDLL 330 Query: 459 GKNEIPIVDTYWQTESGSHLVTPLAGGVTPMKPGSASFPFFGIDAVVLDPNTGEELNTSH 518 G +I + Y TE +T + G PGS P + D N E Sbjct: 331 GPEKI--YEMYSMTECIG--LTCIRGDEWVKHPGSIGRPVGDSKVSIRDENGKEVAPFEI 386 Query: 519 AEGVLAVKAAWPSFARTIWKNHDRYLDTYLNPYP------GYYFTGDGAAKDKDGYIWIL 572 E + A++ + Y+N P G+ GD D+ GY++ Sbjct: 387 GEIYMTAPASY-------------LVTEYINWEPLEVKEGGFRSVGDIGYVDEQGYLYFS 433 Query: 573 GRVDDVVNVSGHRLSTAEIEAAIIEDPIVAECAVVGFNDDLTGQAVAAFVVLKNKSSWST 632 R D++ G + E+E A++ + + VVG D+ G+ + A + T Sbjct: 434 DRRSDMLVSGGENVFATEVETALLRYKDILDAVVVGIPDEDLGRRLHAVI--------ET 485 Query: 633 ATDDELQDIKKHLVFTVRKDIGPFAAPKLIILVDDLPKTRSGKIMR-RILRKILA 686 + +++K L RK + P+ PK V + + +GK R RIL +A Sbjct: 486 GKEIPAEELKTFL----RKYLTPYKIPKTFEFVRSIRRGDNGKADRKRILEDCIA 536 >3L8C-A nrPDB Length = 521 Score = 49.7 bits (117), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 89/403 (22%), Positives = 160/403 (39%), Gaps = 78/403 (19%) Query: 309 VDSEDPLFLLYTSGSTGAPKGVQHSTAGYLL-----------------GALLTMRYTFD- 350 V +D ++++TSG+TG PKGVQ S L L Y+FD Sbjct: 142 VKGDDNYYIIFTSGTTGQPKGVQISHDNLLSFTNWMIEDAAFDVPKQPQMLAQPPYSFDL 201 Query: 351 --THQEDVFFTAGDIGWITGHTYVVYGPLLYGCATL---VFEGTPAYPNYSRYWDIIDEH 405 + G + + + L A L ++ TP++ + + D + Sbjct: 202 SVMYWAPTLALGGTLFALPKELVADFKQLFTTIAQLPVGIWTSTPSFADMAMLSDDFCQA 261 Query: 406 K---VTQFY------VAPTALRLLKRAGDSYIENHSLKSLRCLGSVGEPIAAEVWEWYSE 456 K +T FY TA +L +R S K + G +A E E Sbjct: 262 KMPALTHFYFDGEELTVSTARKLFERF-------PSAKIINAYGPTEATVALSAIEITRE 314 Query: 457 KIGKNEIPIVDTYWQTESGSHLVTPLAGGVTPMKPGSASFPFFGIDAVVLDPNTGEELNT 516 +VD Y + G KP S ++ ++D + G+EL + Sbjct: 315 --------MVDNYTRLPIGYP------------KPDSPTY--------IIDED-GKEL-S 344 Query: 517 SHAEGVLAVKAAWPSFARTIWKNHDRYLDTYLNPYPGY--YFTGDGAAKDKDGYIWILGR 574 S +G + V P+ ++ N ++ + + + G Y TGD + +D + GR Sbjct: 345 SGEQGEIIVTG--PAVSKGYLNNPEKTAEAFFT-FKGQPAYHTGDIGSLTEDNILLYGGR 401 Query: 575 VDDVVNVSGHRLSTAEIEAAIIEDPIVAEC-AVVGFNDDLTGQAVAAFVVLKNKSSWSTA 633 +D + +G+R+ ++ + + P+VA AV +N + Q + A++V+K+ Sbjct: 402 LDFQIKYAGYRIELEDVSQQLNQSPMVASAVAVPRYNKEHKVQNLLAYIVVKD--GVKER 459 Query: 634 TDDELQDIKKHLVFTVRKDIGPFAAPKLIILVDDLPKTRSGKI 676 D EL+ + K + +V+ + + P + D LP T +GKI Sbjct: 460 FDRELE-LTKAIKASVKDHMMSYMMPSKFLYRDSLPLTPNGKI 501 >3LNV-A nrPDB Length = 590 Score = 48.5 bits (114), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 61/251 (24%), Positives = 105/251 (41%), Gaps = 31/251 (12%) Query: 130 QLNACYNCVDRHALKTPNKKAIIFEGDEPGQGYSITYKELLEEVCQVAQVLTYSMGVRKG 189 Q + + V AL +PNKK+ F E + ++TY++L + +A L + G + G Sbjct: 9 QCQSLVDVVRLRALHSPNKKSCTFLNKELEE--TMTYEQLDQHAKAIAATLQ-AEGAKPG 65 Query: 190 DTVAV-YMPMVPEAIITLLAISRIGAIHSVVFAGFSSNSLRDRINDGDSKVVITTDESNR 248 D V + + P +P L + +G +++ A ++++ D ++V + Sbjct: 66 DRVLLLFAPGLP------LIQAFLGCLYAGCIAVPIYPPAQEKLLDKAQRIVTNSKPVIV 119 Query: 249 GGKVIETKRIVDDALRETPGVRHVLVYRKTNNPSVAFHAPRDLDWATEKKKYKTYYPCTP 308 K+ D L P + P++A + E + ++ P T Sbjct: 120 LMIADHIKKFTADELNTNPKFLKI--------PAIALES-------IELNRSSSWQP-TS 163 Query: 309 VDSEDPLFLLYTSGSTGAPKGVQHSTAGYLLGALLTMRYTFDTHQEDVFFT----AGDIG 364 + S D FL YTSGST PKGV S LL L + +F + E + F+ D+G Sbjct: 164 IKSNDIAFLQYTSGSTMHPKGVMVSHHN-LLDNLNKIFTSFHMNDETIIFSWLPPHHDMG 222 Query: 365 WITGHTYVVYG 375 I +YG Sbjct: 223 LIGCILTPIYG 233 Score = 34.7 bits (78), Expect = 0.16, Method: Compositional matrix adjust. Identities = 30/136 (22%), Positives = 63/136 (46%), Gaps = 11/136 (8%) Query: 554 YYFTGD-GAAKDKDGYIWILGRVDDVVNVSGHRLSTAEIEAAIIEDP---IVAECAVVGF 609 Y TGD G + + +++ GR+ D++ + G +IE +++ P ++ +CA Sbjct: 437 YLRTGDLGFLHENE--LYVTGRIKDLIIIYGKNHYPQDIEFSLMHSPLHHVLGKCAAFVI 494 Query: 610 NDDLTGQAVAAFVVLKNKSSWSTATDDELQDIKKHLVFTVRKDIGPFAAPKLIILVDDLP 669 ++ + + +KN+ A D+ +I + + + ++ ++I + +P Sbjct: 495 QEEHEYK-LTVMCEVKNRFMDDVAQDNLFNEIFELVYENHQLEVHTI----VLIPLKAMP 549 Query: 670 KTRSGKIMRRILRKIL 685 T SGKI R RK L Sbjct: 550 HTTSGKIRRNFCRKHL 565 >5ES8-A nrPDB Length = 776 Score = 43.1 bits (100), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 35/140 (25%), Positives = 64/140 (45%), Gaps = 13/140 (9%) Query: 555 YFTGDGAAKDKDGYIWILGRVDDVVNVSGHRLSTAEIEAAIIEDPIVAECAVVGFNDDLT 614 Y TGD A DG I LGR+D++V + G+R+ EIE ++ P++ V+ Sbjct: 564 YRTGDRARFLPDGNIEFLGRLDNLVKIRGYRIEPGEIEPFLMNHPLIELTTVLAKEQADG 623 Query: 615 GQAVAAFVVLKNKSSWSTATDDELQDIKKHLVFTVRKDIGPFAAPKLIILVDDLPKTRSG 674 + + + V + EL++ + D+ + P + + P T +G Sbjct: 624 RKYLVGYYVAPEEIPHG-----ELRE-------WLGNDLPDYMIPTYFVHMKAFPLTANG 671 Query: 675 KIMRRILRKILAGESDQLGD 694 K+ RR L + A +++ LG+ Sbjct: 672 KVDRRALPDVQA-DAELLGE 690 Score = 40.8 bits (94), Expect = 0.002, Method: Compositional matrix adjust. Identities = 44/189 (23%), Positives = 76/189 (40%), Gaps = 46/189 (24%) Query: 145 TPNKKAIIFEGDEPGQGYSITYKELLEEVCQVAQVLTYSMGVRKGDTVAVYMPMVPEAII 204 TP+ A++ +G S+TYK+L E Q+A L GV+ D VA+ + + I+ Sbjct: 216 TPDHVAVV------DRGQSLTYKQLNERANQLAHHLR-GKGVKPDDQVAIMLDKSLDMIV 268 Query: 205 TLLAISRIGAIHSVVFAGFSSNSLRDRINDGDSKVVITT---DESNRGGKVIETKRIVDD 261 ++LA+ + G + + + + + D + +++T +E G I D Sbjct: 269 SILAVMKAGGAYVPIDPDYPGERIAYMLADSSAAILLTNALHEEKANGACDIIDVHDPDS 328 Query: 262 ALRETPGVRHVLVYRKTNNPSVAFHAPRDLDWATEKKKYKTYYPCTPVDSEDPLFLLYTS 321 T + HV N P +D ++++YTS Sbjct: 329 YSENTNNLPHV------NRP------------------------------DDLVYVMYTS 352 Query: 322 GSTGAPKGV 330 GSTG KGV Sbjct: 353 GSTGLAKGV 361 >5ES6-A nrPDB Length = 685 Score = 42.7 bits (99), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 33/132 (25%), Positives = 58/132 (43%), Gaps = 12/132 (9%) Query: 555 YFTGDGAAKDKDGYIWILGRVDDVVNVSGHRLSTAEIEAAIIEDPIVAECAVVGFNDDLT 614 Y TGD A DG I LGR+D++V + G+R+ EIE ++ P++ V+ Sbjct: 564 YRTGDRARFLPDGNIEFLGRLDNLVKIRGYRIEPGEIEPFLMNHPLIELTTVLAKEQADG 623 Query: 615 GQAVAAFVVLKNKSSWSTATDDELQDIKKHLVFTVRKDIGPFAAPKLIILVDDLPKTRSG 674 + + + V + EL++ + D+ + P + + P T +G Sbjct: 624 RKYLVGYYVAPEEIPHG-----ELRE-------WLGNDLPDYMIPTYFVHMKAFPLTANG 671 Query: 675 KIMRRILRKILA 686 K+ RR L + A Sbjct: 672 KVDRRALPDVQA 683 Score = 40.8 bits (94), Expect = 0.002, Method: Compositional matrix adjust. Identities = 44/189 (23%), Positives = 76/189 (40%), Gaps = 46/189 (24%) Query: 145 TPNKKAIIFEGDEPGQGYSITYKELLEEVCQVAQVLTYSMGVRKGDTVAVYMPMVPEAII 204 TP+ A++ +G S+TYK+L E Q+A L GV+ D VA+ + + I+ Sbjct: 216 TPDHVAVV------DRGQSLTYKQLNERANQLAHHLR-GKGVKPDDQVAIMLDKSLDMIV 268 Query: 205 TLLAISRIGAIHSVVFAGFSSNSLRDRINDGDSKVVITT---DESNRGGKVIETKRIVDD 261 ++LA+ + G + + + + + D + +++T +E G I D Sbjct: 269 SILAVMKAGGAYVPIDPDYPGERIAYMLADSSAAILLTNALHEEKANGACDIIDVHDPDS 328 Query: 262 ALRETPGVRHVLVYRKTNNPSVAFHAPRDLDWATEKKKYKTYYPCTPVDSEDPLFLLYTS 321 T + HV N P +D ++++YTS Sbjct: 329 YSENTNNLPHV------NRP------------------------------DDLVYVMYTS 352 Query: 322 GSTGAPKGV 330 GSTG KGV Sbjct: 353 GSTGLAKGV 361 >3E7W-A nrPDB Length = 511 Score = 41.6 bits (96), Expect = 0.001, Method: Compositional matrix adjust. Identities = 49/176 (27%), Positives = 78/176 (44%), Gaps = 32/176 (18%) Query: 160 QGYSITYKELLEEVCQVAQVLTYSMGVRKGDTVAVYMPMVPEAIITLLAISRIGAIHSVV 219 QG S+TY+EL E+ + A + + K + VY M P I++ L + G H + Sbjct: 23 QGQSLTYQELWEQSDRAAAAIQKRISGEKKSPILVYGHMEPHMIVSFLGSVKAG--HPYI 80 Query: 220 FAGFSSNSLRDRINDGDSKVVITTDESNRGGKVIETKRIVDDALRETPGVRHVLVYRKTN 279 S S +RI +K++ ES+ +I + DA+ + + Sbjct: 81 PVDLSIPS--ERI----AKII----ESSGAELLIHAAGLSIDAVGQQIQTVSAEELLENE 130 Query: 280 NPSVAFHAPRDLDWATEKKKYKTYYPCTPVDSEDPLFLLYTSGSTGAPKGVQHSTA 335 SV+ +D W K+++T+Y ++YTSGSTG PKGVQ S A Sbjct: 131 GGSVS----QD-QWV---KEHETFY------------IIYTSGSTGNPKGVQISAA 166 Score = 40.0 bits (92), Expect = 0.004, Method: Compositional matrix adjust. Identities = 38/135 (28%), Positives = 62/135 (45%), Gaps = 14/135 (10%) Query: 555 YFTGDGAAKDKDGYIWILGRVDDVVNVSGHRLSTAEIEAAIIEDPIVAECAVVGFNDDLT 614 Y TGD A +DG I+ GR+D + + G+R+ EIE + + V V+ + + T Sbjct: 378 YRTGD-AGFIQDGQIFCQGRLDFQIKLHGYRMELEEIEFHVRQSQYVRSAVVIPYQPNGT 436 Query: 615 GQAVAAFVVLKNKSSWSTATDDELQ---DIKKHLVFTVRKDIGPFAAPKLIILVDDLPKT 671 + + A +V + + E Q IKK L + + P+ I D + T Sbjct: 437 VEYLIAAIVPEEHE-----FEKEFQLTSAIKKELA----ASLPAYMIPRKFIYQDHIQMT 487 Query: 672 RSGKIMR-RILRKIL 685 +GKI R RI ++L Sbjct: 488 ANGKIDRKRIGEEVL 502 >4R0M-B nrPDB Length = 643 Score = 41.2 bits (95), Expect = 0.002, Method: Compositional matrix adjust. Identities = 37/175 (21%), Positives = 78/175 (44%), Gaps = 11/175 (6%) Query: 309 VDSEDPLFLLYTSGSTGAPKGV---QHSTAGYLLGALLTMRYTFDTHQEDVFFTAGDIGW 365 +D +D LL+TSGSTG PKGV H+ G ++ +T Q++V + Sbjct: 171 LDPQDAALLLFTSGSTGMPKGVILTHHNILSMTAGTVVMNHFT----QQEVTLNWMPLDH 226 Query: 366 ITGHTYVVYGPLLYGCATLVFEGTPAYPNYSRYWDIIDEHKVTQFYVAPTALRLLKRAGD 425 + ++ + C + ++ ++I +H+V+ + A L+ + + Sbjct: 227 VGAIVFLGIMAVDLACDQIHVPMELVLRQPLQWLELIQKHQVSISWSPNFAFSLINQQAE 286 Query: 426 SYIE-NHSLKSLRCLGSVGEPIAAEVWEWYSEKIGKNEI---PIVDTYWQTESGS 476 +++L S++ L + GE ++ + + E + K+++ I + TES S Sbjct: 287 ELKHVSYNLSSMKFLVNAGEQVSVKTIRLFLEILEKHQLQERAIKPAFGMTESCS 341 >5JNF-C nrPDB Length = 587 Score = 40.8 bits (94), Expect = 0.002, Method: Compositional matrix adjust. Identities = 44/189 (23%), Positives = 76/189 (40%), Gaps = 46/189 (24%) Query: 145 TPNKKAIIFEGDEPGQGYSITYKELLEEVCQVAQVLTYSMGVRKGDTVAVYMPMVPEAII 204 TP+ A++ +G S+TYK+L E Q+A L GV+ D VA+ + + I+ Sbjct: 218 TPDHVAVV------DRGQSLTYKQLNERANQLAHHLR-GKGVKPDDQVAIMLDKSLDMIV 270 Query: 205 TLLAISRIGAIHSVVFAGFSSNSLRDRINDGDSKVVITT---DESNRGGKVIETKRIVDD 261 ++LA+ + G + + + + + D + +++T +E G I D Sbjct: 271 SILAVMKAGGAYVPIDPDYPGERIAYMLADSSAAILLTNALHEEKANGACDIIDVHDPDS 330 Query: 262 ALRETPGVRHVLVYRKTNNPSVAFHAPRDLDWATEKKKYKTYYPCTPVDSEDPLFLLYTS 321 T + HV N P +D ++++YTS Sbjct: 331 YSENTNNLPHV------NRP------------------------------DDLVYVMYTS 354 Query: 322 GSTGAPKGV 330 GSTG KGV Sbjct: 355 GSTGLAKGV 363 >3E53-A nrPDB Length = 480 Score = 39.3 bits (90), Expect = 0.007, Method: Compositional matrix adjust. Identities = 58/212 (27%), Positives = 77/212 (36%), Gaps = 38/212 (17%) Query: 127 LNGQLNACYNCVDRHALKTPNKKAIIF---EGDEPGQGYSITYKELLEEVCQVAQVLTYS 183 L L AC A P+ A F E D G ++T+ +L VAQ L+ Sbjct: 26 LPAALRAC-------ARLQPHDPAFTFMDYEQDWDGVAITLTWSQLYRRTLNVAQELSRC 78 Query: 184 MGVRKGDTVAVYMPMVPEAIITLLAISRIG--AIHSVVFAGFSSNSLRDRINDGDSKVVI 241 GD V + P E ++ L + G A+ V G ++ D + S V I Sbjct: 79 GST--GDRVVISAPQGLEYVVAFLGALQAGRIAVPLSVPQGGVTDERSDSVLSDSSPVAI 136 Query: 242 TTDESNRGGKVIETKRIVDDALRETPGVRHVLVYRKTNNPSVAFHAPRDLDWATEKKKYK 301 T T VDD V+HV + PS+ DLD + Sbjct: 137 LT-----------TSSAVDDV------VQHVARRPGESPPSIIEVDLLDLDAPNGYTFKE 179 Query: 302 TYYPCTPVDSEDPLFLLYTSGSTGAPKGVQHS 333 YP T +L YTSGST P GV S Sbjct: 180 DEYPST-------AYLQYTSGSTRTPAGVVMS 204 >3FCE-A nrPDB Length = 512 Score = 38.9 bits (89), Expect = 0.008, Method: Compositional matrix adjust. Identities = 41/194 (21%), Positives = 82/194 (42%), Gaps = 37/194 (19%) Query: 138 VDRHALKTPNKKAIIFEGDEPGQGYSITYKELLEEVCQVAQVLTYSMGVRKGDTVAVYMP 197 +++ A +TP++ A ++ + ITYK+L E+ +A ++ + + VY Sbjct: 7 IEKWAAETPDQTAFVW------RDAKITYKQLKEDSDALAHWISSEYPDDRS-PIMVYGH 59 Query: 198 MVPEAIITLLAISRIGAIHSVVFAGFSSNSLRDRINDGDSKVVITTDESNRGGKVIETKR 257 M PE II L + G + V ++ ++ + +K++++ + + Sbjct: 60 MQPEMIINFLGCVKAGHAYIPVDLSIPADRVQRIAENSGAKLLLSATAVTVTD--LPVRI 117 Query: 258 IVDDALRETPGVRHVLVYRKTNNPSVAFHAPRDLDWATEKKKYKTYYPCTPVDSEDPLFL 317 + +D L++ + K N P+ P V ++ ++ Sbjct: 118 VSEDNLKD------IFFTHKGNTPN----------------------PEHAVKGDENFYI 149 Query: 318 LYTSGSTGAPKGVQ 331 +YTSGSTG PKGVQ Sbjct: 150 IYTSGSTGNPKGVQ 163 >4RVO-A nrPDB Length = 436 Score = 38.5 bits (88), Expect = 0.011, Method: Compositional matrix adjust. Identities = 38/131 (29%), Positives = 52/131 (39%), Gaps = 10/131 (7%) Query: 295 TEKKKYKTYYPCTPVDSE---DPLFLLYTSGSTGAPKGVQHSTAGYLLGALLTMR--YTF 349 T K + YP V + D + + +SG+TG P + HS A L R Y Sbjct: 66 TTKSDMRANYPFGLVAGDMKRDGVRIHSSSGTTGNPTVIVHSQHDLDSWANLVARCLYMV 125 Query: 350 DTHQEDVFFTAGDIGWITGHTYVVYGPLLYGCATLVFEGTPAYPNYSRYWDIIDEHKVTQ 409 + DVF + G TG YG GC T+ A N R I + K T Sbjct: 126 GIRKTDVFQNSSGYGMFTGGLGFQYGAERLGCLTV----PAAAGNSKRQIKFISDFKTTA 181 Query: 410 FYVAPT-ALRL 419 + P+ A+RL Sbjct: 182 LHAIPSYAIRL 192 >2Y4O-A nrPDB Length = 443 Score = 34.7 bits (78), Expect = 0.16, Method: Compositional matrix adjust. Identities = 43/182 (23%), Positives = 79/182 (43%), Gaps = 20/182 (10%) Query: 505 VLDPNTGEEL-NTSHAEGVLA--VKAAWPSFARTIWKNHDRYLDTYLNPYPGYYFTGDGA 561 ++DP TGE L + S E V K A P + + R L L P Sbjct: 276 IIDPVTGEVLPDGSQGELVFTSLTKEAMP-----VIRYRTRDLTALLPP----------T 320 Query: 562 AKDKDGYIWILGRVDDVVNVSGHRLSTAEIEAAIIEDPIVAECAVVGFNDDLTGQAVAAF 621 A+ I GR DD++ V G + ++IE ++ P+++ + + D + Sbjct: 321 ARAMRRLAKITGRSDDMLIVRGVNVFPSQIEEIVVALPLLSGQFQITLSRDGHMDRLDLA 380 Query: 622 VVLKNKSSWSTATDDELQDIKKHLVFTVRKDIGPFAAPKLIILVDDLPKTRSGKIMRRIL 681 V L+++++ S TD E + + L ++ +G ++ ++ +P T +GK R I Sbjct: 381 VELRSEAAASV-TDGERAALARELQHRIKTMVG-VSSGVTVLAAGGIPATATGKARRVID 438 Query: 682 RK 683 R+ Sbjct: 439 RR 440 >6NJ0-A nrPDB Length = 451 Score = 31.6 bits (70), Expect = 1.1, Method: Compositional matrix adjust. Identities = 69/301 (22%), Positives = 113/301 (37%), Gaps = 48/301 (15%) Query: 317 LLYTSGSTGAPKGVQHSTAGYLLGALLTMRYT-FDTHQEDVFFTAGDIGWITGHTYVVYG 375 + TSGSTG PK H+ +L A + F H D + + + ++G + Sbjct: 139 MTLTSGSTGLPKAAVHTYQAHLASAQGVLSLIPFGDH--DDWLLSLPLFHVSGQG--IMW 194 Query: 376 PLLYGCATLVFEGTPAYPNYSRYWDIIDEHKVTQFYVAPTALRLLKRAGDSYIENHSLKS 435 LY A + + D+ + Q T L+ + N S S Sbjct: 195 RWLYAGARMT---------------VRDKQPLEQMLAGCTHASLVPTQLWRLLVNRSSVS 239 Query: 436 LRCLGSVGEPIAAEVWEWYSEKIGKNEIPIVDTYWQTESGSHLVTPLAGGVTPMKPGSAS 495 L+ + G I E+ +E+ + I Y TE S + A G+ Sbjct: 240 LKAVLLGGAAIPVEL----TEQAREQGIRCFCGYGLTEFASTVCAKEADGL--------- 286 Query: 496 FPFFGIDAVVLDPNTGEELNTSHAEGVLAVKAAWPSFARTIWKNHDRYLDTYLNPYPGYY 555 A V P G E+ + E + ++AA S A W+N L + +N G+Y Sbjct: 287 -------ADVGSPLPGREVKIVNNE--VWLRAA--SMAEGYWRNGQ--LVSLVND-EGWY 332 Query: 556 FTGDGAAKDKDGYIWILGRVDDVVNVSGHRLSTAEIEAAIIEDPIVAECAVVGFNDDLTG 615 T D + +G + I+GR+D++ G + E+E I P V + +V D G Sbjct: 333 ATRD-RGEMHNGKLTIVGRLDNLFFSGGEGIQPEEVERVIAAHPAVLQVFIVPVADKEFG 391 Query: 616 Q 616 Sbjct: 392 H 392 >5NPY-A nrPDB Length = 618 Score = 31.6 bits (70), Expect = 1.4, Method: Compositional matrix adjust. Identities = 21/72 (29%), Positives = 32/72 (44%) Query: 539 NHDRYLDTYLNPYPGYYFTGDGAAKDKDGYIWILGRVDDVVNVSGHRLSTAEIEAAIIED 598 N R D YL GYY G K KDG + R +D+ + G+ LS +I + Sbjct: 127 NFARDADGYLVTPEGYYVYGIDLKKIKDGTLNSTARDEDIEKLHGNTLSPLQIPQDLTYQ 186 Query: 599 PIVAECAVVGFN 610 P+++ + N Sbjct: 187 PVLSTKVGISVN 198 >3PBK-A nrPDB Length = 583 Score = 31.2 bits (69), Expect = 1.5, Method: Compositional matrix adjust. Identities = 30/119 (25%), Positives = 57/119 (47%), Gaps = 11/119 (9%) Query: 566 DGYIWILGRVDDVVNVSGHRLSTAEIEAAIIEDPIVAECAVVGFNDDLTGQAVAAFVVLK 625 DGY+++ GR+ D++ + G + +IE ++P + + F +T Q ++L+ Sbjct: 450 DGYLYVTGRIKDLIIIRGRNIWPQDIEYIAEQEPEIHSGDAIAF---VTAQEK---IILQ 503 Query: 626 NKSSWSTATDDELQDIKKH-LVFTVRKDIGPFAAPKLIILVDDLPKTRSGKIMRRILRK 683 + S D+E + H L ++ + G AA L+ +P+T SGK R +K Sbjct: 504 IQCRIS---DEERRGQLIHALAARIQSEFGVTAAIDLLP-PHSIPRTSSGKPARAEAKK 558 >3K9T-A nrPDB Length = 435 Score = 30.8 bits (68), Expect = 2.2, Method: Compositional matrix adjust. Identities = 39/146 (26%), Positives = 58/146 (39%), Gaps = 25/146 (17%) Query: 532 FARTIWKNHDR--YLDTYLNPYPGYYFTGDGAAK--DKDGYIWILGRVDDVVNVSGHRLS 587 + TI N DR YL +Y G+ T + + D D + I ++D G Sbjct: 115 YLHTIPGNKDRIPYLTSYYKENWGFSLTQNKFDELCDDDYEVVIDSSLEDGSLTYGEYYI 174 Query: 588 TAEIEAAIIEDPIVAECAVVGFNDDLTGQAVAAFVV-----LKNKSS------------- 629 E+E I+ C ND+L+G A+ F+ LK K S Sbjct: 175 RGELEEEIL--LTTYTCHPSMCNDNLSGVALITFIAKALSKLKTKYSYRFLFAPETIGSI 232 Query: 630 -WSTATDDELQDIKKHLVFTVRKDIG 654 W + +D+L++IK LV T D G Sbjct: 233 TWLSRNEDKLKNIKMGLVATCVGDAG 258 >6FSZ-KK nrPDB Length = 733 Score = 30.4 bits (67), Expect = 3.1, Method: Compositional matrix adjust. Identities = 23/68 (33%), Positives = 36/68 (52%), Gaps = 9/68 (13%) Query: 58 LQPAIATHYSPHLDGLQDYQRLHKESIE--DPAKFFGSKATQFLNWSKPFDKVFIPDPKT 115 + PA A ++SP +D L D L K++I+ PAK G +++SK IP+ + Sbjct: 636 VDPASAPNHSPEIDNLDDLVVLKKKNIQKKQPAKEKGVTEKDAVDYSK------IPNILS 689 Query: 116 GRPSFQNN 123 +P QNN Sbjct: 690 NKPG-QNN 696 >5ACA-1 nrPDB Length = 214 Score = 30.0 bits (66), Expect = 3.6, Method: Compositional matrix adjust. Identities = 17/42 (40%), Positives = 20/42 (47%) Query: 235 GDSKVVITTDESNRGGKVIETKRIVDDALRETPGVRHVLVYR 276 G+ V+TTD S GG V E KR+ D HVL R Sbjct: 5 GEGADVVTTDPSTHGGAVTEKKRVHTDVAFVMDRFTHVLTNR 46 >2RAG-A nrPDB Length = 417 Score = 30.0 bits (66), Expect = 3.8, Method: Compositional matrix adjust. Identities = 22/84 (26%), Positives = 35/84 (41%), Gaps = 8/84 (9%) Query: 223 FSSNSLRDRINDGDSKV--------VITTDESNRGGKVIETKRIVDDALRETPGVRHVLV 274 F +N L D D K+ + E+NR G VI+ DD + ++ + + Sbjct: 187 FRNNQLADSSTDPKGKIWNGYSPLGLRWLAEANRLGIVIDVSHASDDVVDQSVALSKAPI 246 Query: 275 YRKTNNPSVAFHAPRDLDWATEKK 298 + P + PR+LD A KK Sbjct: 247 IASHSGPKAVYDHPRNLDDARLKK 270 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 1RY2-A nrPDB 819 0.0 5U29-A nrPDB 664 0.0 5JRH-A nrPDB 662 0.0 4WD1-A nrPDB 492 e-139 3ETC-A nrPDB 462 e-130 4WV3-A nrPDB 430 e-120 3GPC-A nrPDB 426 e-119 3TSY-A nrPDB 415 e-116 3A9U-A nrPDB 415 e-116 5BSW-A nrPDB 409 e-114 3R44-A nrPDB 407 e-113 5IE2-A nrPDB 407 e-113 4EAT-A nrPDB 397 e-111 5BUS-A nrPDB 393 e-109 4FUQ-A nrPDB 389 e-108 2V7B-A nrPDB 381 e-106 3IVR-A nrPDB 380 e-106 1MDF-A nrPDB 379 e-105 3RG2-A nrPDB 375 e-104 4GR5-A nrPDB 356 2e-98 5DWV-A nrPDB 355 3e-98 4M46-A nrPDB 355 5e-98 3DLP-X nrPDB 348 4e-96 2D1S-A nrPDB 343 1e-94 3O84-A nrPDB 342 3e-94 3IPL-A nrPDB 336 2e-92 1V25-A nrPDB 297 7e-81 5ES8-A nrPDB 270 1e-72 4LGC-A nrPDB 267 1e-71 5ES6-A nrPDB 266 2e-71 5WMM-A nrPDB 266 3e-71 4GR4-A nrPDB 261 6e-70 3LNV-A nrPDB 252 3e-67 3L8C-A nrPDB 247 1e-65 3E7W-A nrPDB 240 1e-63 4R0M-B nrPDB 215 6e-56 Sequences not found previously or not previously below threshold: 3FCE-A nrPDB 222 3e-58 3PBK-A nrPDB 193 2e-49 5EY8-A nrPDB 177 1e-44 5JNF-C nrPDB 175 5e-44 6NJ0-A nrPDB 163 2e-40 5HM3-A nrPDB 156 3e-38 5EY9-A nrPDB 153 3e-37 5D6N-A nrPDB 152 5e-37 3E53-A nrPDB 140 2e-33 4RVO-A nrPDB 107 2e-23 2Y4O-A nrPDB 101 1e-21 2Y4N-A nrPDB 91 2e-18 6HIV-BC nrPDB 59 5e-09 5YV5-A nrPDB 36 0.058 5YHV-A nrPDB 36 0.059 2YWB-A nrPDB 33 0.41 1RPZ-A nrPDB 33 0.65 3J15-B nrPDB 32 0.78 3KGX-A nrPDB 32 0.89 3WO8-A nrPDB 32 1.1 3WBH-A nrPDB 31 1.3 2I2W-A nrPDB 31 1.4 3L44-A nrPDB 31 1.6 4GAX-A nrPDB 31 1.8 2EG4-A nrPDB 31 1.8 5BV0-A nrPDB 31 1.9 5LHE-A nrPDB 30 2.9 >1RY2-A nrPDB Length = 663 Score = 819 bits (2115), Expect = 0.0, Method: Composition-based stats. Identities = 643/647 (99%), Positives = 644/647 (99%), Gaps = 1/647 (0%) Query: 67 SPHLDGLQDYQRLHKESIEDPAKFFGSKATQFLNWSKPFDKVFIPDPKTGRPSFQNNAWF 126 H+ GLQDYQRLHKESIEDPAKFFGSKATQFLNWSKPFDKVFIPDPKTGRPSFQNNAWF Sbjct: 18 GSHM-GLQDYQRLHKESIEDPAKFFGSKATQFLNWSKPFDKVFIPDPKTGRPSFQNNAWF 76 Query: 127 LNGQLNACYNCVDRHALKTPNKKAIIFEGDEPGQGYSITYKELLEEVCQVAQVLTYSMGV 186 LNGQLNACYNCVDRHALKTPNKKAIIFEGDEPGQGYSITYKELLEEVCQVAQVLTYSMGV Sbjct: 77 LNGQLNACYNCVDRHALKTPNKKAIIFEGDEPGQGYSITYKELLEEVCQVAQVLTYSMGV 136 Query: 187 RKGDTVAVYMPMVPEAIITLLAISRIGAIHSVVFAGFSSNSLRDRINDGDSKVVITTDES 246 RKGDTVAVYMPMVPEAIITLLAISRIGAIHSVVFAGFSSNSLRDRINDGDSKVVITTDES Sbjct: 137 RKGDTVAVYMPMVPEAIITLLAISRIGAIHSVVFAGFSSNSLRDRINDGDSKVVITTDES 196 Query: 247 NRGGKVIETKRIVDDALRETPGVRHVLVYRKTNNPSVAFHAPRDLDWATEKKKYKTYYPC 306 NRGGKVIETKRIVDDALRETPGVRHVLVYRKTNNPSVAFHAPRDLDWATEKKKYKTYYPC Sbjct: 197 NRGGKVIETKRIVDDALRETPGVRHVLVYRKTNNPSVAFHAPRDLDWATEKKKYKTYYPC 256 Query: 307 TPVDSEDPLFLLYTSGSTGAPKGVQHSTAGYLLGALLTMRYTFDTHQEDVFFTAGDIGWI 366 TPVDSEDPLFLLYTSGSTGAPKGVQHSTAGYLLGALLTMRYTFDTHQEDVFFTAGDIGWI Sbjct: 257 TPVDSEDPLFLLYTSGSTGAPKGVQHSTAGYLLGALLTMRYTFDTHQEDVFFTAGDIGWI 316 Query: 367 TGHTYVVYGPLLYGCATLVFEGTPAYPNYSRYWDIIDEHKVTQFYVAPTALRLLKRAGDS 426 TGHTYVVYGPLLYGCATLVFEGTPAYPNYSRYWDIIDEHKVTQFYVAPTALRLLKRAGDS Sbjct: 317 TGHTYVVYGPLLYGCATLVFEGTPAYPNYSRYWDIIDEHKVTQFYVAPTALRLLKRAGDS 376 Query: 427 YIENHSLKSLRCLGSVGEPIAAEVWEWYSEKIGKNEIPIVDTYWQTESGSHLVTPLAGGV 486 YIENHSLKSLRCLGSVGEPIAAEVWEWYSEKIGKNEIPIVDTYWQTESGSHLVTPLAGGV Sbjct: 377 YIENHSLKSLRCLGSVGEPIAAEVWEWYSEKIGKNEIPIVDTYWQTESGSHLVTPLAGGV 436 Query: 487 TPMKPGSASFPFFGIDAVVLDPNTGEELNTSHAEGVLAVKAAWPSFARTIWKNHDRYLDT 546 TPMKPGSASFPFFGIDAVVLDPNTGEELNTSHAEGVLAVKAAWPSFARTIWKNHDRYLDT Sbjct: 437 TPMKPGSASFPFFGIDAVVLDPNTGEELNTSHAEGVLAVKAAWPSFARTIWKNHDRYLDT 496 Query: 547 YLNPYPGYYFTGDGAAKDKDGYIWILGRVDDVVNVSGHRLSTAEIEAAIIEDPIVAECAV 606 YLNPYPGYYFTGDGAAKDKDGYIWILGRVDDVVNVSGHRLSTAEIEAAIIEDPIVAECAV Sbjct: 497 YLNPYPGYYFTGDGAAKDKDGYIWILGRVDDVVNVSGHRLSTAEIEAAIIEDPIVAECAV 556 Query: 607 VGFNDDLTGQAVAAFVVLKNKSSWSTATDDELQDIKKHLVFTVRKDIGPFAAPKLIILVD 666 VGFNDDLTGQAVAAFVVLKNKSSWSTATDDELQDIKKHLVFTVRKDIGPFAAPKLIILVD Sbjct: 557 VGFNDDLTGQAVAAFVVLKNKSSWSTATDDELQDIKKHLVFTVRKDIGPFAAPKLIILVD 616 Query: 667 DLPKTRSGKIMRRILRKILAGESDQLGDVSTLSNPGIVRHLIDSVKL 713 DLPKTRSGKIMRRILRKILAGESDQLGDVSTLSNPGIVRHLIDSVKL Sbjct: 617 DLPKTRSGKIMRRILRKILAGESDQLGDVSTLSNPGIVRHLIDSVKL 663 >5U29-A nrPDB Length = 694 Score = 664 bits (1713), Expect = 0.0, Method: Composition-based stats. Identities = 352/624 (56%), Positives = 439/624 (70%), Gaps = 11/624 (1%) Query: 88 AKFFGSKATQFLNWSKPFDKVFIPDPKTGRPSFQNNAWFLNGQLNACYNCVDRHALKTPN 147 +++ +KA + L+W F V + G + WF G LNA YNC+DRH K P Sbjct: 78 DEWWAAKARETLDWYDDFKTV-----RAGGFEHGDVQWFPEGTLNAAYNCLDRHYYKNPK 132 Query: 148 KKAIIFEGDEPGQGYSITYKELLEEVCQVAQVLTYSMGVRKGDTVAVYMPMVPEAIITLL 207 K AII+E DEP + ++Y+EL++E C+VA VL S GV+KGD V++Y+PM +A L Sbjct: 133 KTAIIYEADEPSESREVSYEELMQETCRVANVL-KSYGVKKGDAVSIYLPMTWQAAAAFL 191 Query: 208 AISRIGAIHSVVFAGFSSNSLRDRINDGDSKVVITTDESNRGGKVIETKRIVDDALRETP 267 A +RIGAIHS VFAGFS+ SLRDR+ND + KV+ITTDE RGGK I TK+IVD AL++ P Sbjct: 192 ACARIGAIHSAVFAGFSAESLRDRVNDCECKVLITTDEGRRGGKTIATKQIVDAALQQCP 251 Query: 268 GVRHVLVYRKTNNPSVAFHAPRDLDWATEKKKYKTYYPCTPVDSEDPLFLLYTSGSTGAP 327 V +VLV R+T N V RD W E K Y PC + SEDPLF+LYTSGSTG P Sbjct: 252 LVENVLVLRRTGN-KVPMTEGRDKWWDEECAKMPAYCPCERMASEDPLFILYTSGSTGKP 310 Query: 328 KGVQHSTAGYLLGALLTMRYTFDTHQEDVFFTAGDIGWITGHTYVVYGPLLYGCATLVFE 387 KGV HSTAGYLLG LT++Y FD H +D F DIGWITGH+Y++YGPL G T VFE Sbjct: 311 KGVVHSTAGYLLGTALTLKYVFDAHPDDRFACMADIGWITGHSYIIYGPLANGITTAVFE 370 Query: 388 GTPAYPNYSRYWDIIDEHKVTQFYVAPTALRLLKRAGDSYIENHSLKSLRCLGSVGEPIA 447 TP YP SRYWD +D+ K TQ Y APTA+RLL+R G+ +++NH L SLR LGSVGEPI Sbjct: 371 STPVYPTPSRYWDFVDKWKATQLYTAPTAIRLLRRMGEDHVKNHDLSSLRVLGSVGEPIN 430 Query: 448 AEVWEWYSEKIGKNEIPIVDTYWQTESGSHLVTPLAGGVTPMKPGSASFPFFGIDAVVLD 507 E W WY++ GKN+ IVDTYW TE+GS + PL G ++ KPGSA+FPFFG+D ++D Sbjct: 431 PEAWHWYNDFAGKNQCAIVDTYWMTETGSISIAPLPGAIS-TKPGSATFPFFGMDVDIID 489 Query: 508 PNTGEELNTSHAEGVLAVKAAWPSFARTIWKNHDRYLDTYLNPYPGYYFTGDGAAKDKDG 567 P TG+ L + EGVL + WPS ART++++H RYL+TY+ PYPGY+F GDGAA+D DG Sbjct: 490 PQTGQVLEGNDVEGVLVARRPWPSIARTVYRDHKRYLETYMKPYPGYFFFGDGAARDYDG 549 Query: 568 YIWILGRVDDVVNVSGHRLSTAEIEAAIIEDPIVAECAVVGFNDDLTGQAVAAFVVLKNK 627 Y+WI GRVDDV+NVSGHRLSTAE+E+A+I VAE AVVG DDLTGQAV AFV +K + Sbjct: 550 YMWIKGRVDDVINVSGHRLSTAEVESALILHKGVAETAVVGCADDLTGQAVYAFVTMKPE 609 Query: 628 SSWSTATDDELQDIKKHLVFTVRKDIGPFAAPKLIILVDDLPKTRSGKIMRRILRKILAG 687 + D+ K L VRK IGPFAAPK I LV DLPKTRSGKIMRR+LRKI+AG Sbjct: 610 FDLKATKE---ADLSKELAIQVRKVIGPFAAPKKIYLVSDLPKTRSGKIMRRVLRKIVAG 666 Query: 688 ESDQLGDVSTLSNPGIVRHLIDSV 711 E DQLGD+S++++P IV + V Sbjct: 667 EGDQLGDLSSIADPQIVEEVKQKV 690 >5JRH-A nrPDB Length = 660 Score = 662 bits (1708), Expect = 0.0, Method: Composition-based stats. Identities = 297/639 (46%), Positives = 413/639 (64%), Gaps = 18/639 (2%) Query: 74 QDYQRLHKESIEDPAKFFGSKATQFLNWSKPFDKVFIPDPKTGRPSFQNNAWFLNGQLNA 133 + Y+ +K+SI DP F+G + + L+W P+ KV G S + W+ +G LN Sbjct: 22 EQYETKYKQSINDPDTFWGEQG-KILDWITPYQKVKNTSFAPGNVSIK---WYEDGTLNL 77 Query: 134 CYNCVDRHALKTPNKKAIIFEGDEPGQGYSITYKELLEEVCQVAQVLTYSMGVRKGDTVA 193 NC+DRH + ++ AII+EGD+ Q I+Y+EL +VC+ A L +G++KGD VA Sbjct: 78 AANCLDRHLQENGDRTAIIWEGDDTSQSKHISYRELHRDVCRFANTLL-DLGIKKGDVVA 136 Query: 194 VYMPMVPEAIITLLAISRIGAIHSVVFAGFSSNSLRDRINDGDSKVVITTDESNRGGKVI 253 +YMPMVPEA + +LA +RIGA+HSV+F GFS ++ RI D S++VIT DE R G+ I Sbjct: 137 IYMPMVPEAAVAMLACARIGAVHSVIFGGFSPEAVAGRIIDSSSRLVITADEGVRAGRSI 196 Query: 254 ETKRIVDDAL--RETPGVRHVLVYRKTNNPSVAFHAPRDLDWATEKKKYKTYYPCTPVDS 311 K+ VDDAL V HV+V ++T + + + RDL W +K + +++ Sbjct: 197 PLKKNVDDALKNPNVTSVEHVIVLKRTGS-DIDWQEGRDLWWRDLIEKASPEHQPEAMNA 255 Query: 312 EDPLFLLYTSGSTGAPKGVQHSTAGYLLGALLTMRYTFDTHQEDVFFTAGDIGWITGHTY 371 EDPLF+LYTSGSTG PKGV H+T GYL+ A T +Y FD H D+++ D+GW+TGH+Y Sbjct: 256 EDPLFILYTSGSTGKPKGVLHTTGGYLVYAATTFKYVFDYHPGDIYWCTADVGWVTGHSY 315 Query: 372 VVYGPLLYGCATLVFEGTPAYPNYSRYWDIIDEHKVTQFYVAPTALRLLKRAGDSYIENH 431 ++YGPL G TL+FEG P +P +R ++D+H+V Y APTA+R L GD IE Sbjct: 316 LLYGPLACGATTLMFEGVPNWPTPARMCQVVDKHQVNILYTAPTAIRALMAEGDKAIEGT 375 Query: 432 SLKSLRCLGSVGEPIAAEVWEWYSEKIGKNEIPIVDTYWQTESGSHLVTPLAGGVTPMKP 491 SLR LGSVGEPI E WEWY +KIGK + P+VDT+WQTE+G ++TPL G + +K Sbjct: 376 DRSSLRILGSVGEPINPEAWEWYWKKIGKEKCPVVDTWWQTETGGFMITPLPGAI-ELKA 434 Query: 492 GSASFPFFGIDAVVLDPNTGEELNTSHAEGVLAVKAAWPSFARTIWKNHDRYLDTYLNPY 551 GSA+ PFFG+ ++D N G + EG L + +WP ART++ +H+R+ TY + + Sbjct: 435 GSATRPFFGVQPALVD-NEGHPQEGA-TEGNLVITDSWPGQARTLFGDHERFEQTYFSTF 492 Query: 552 PGYYFTGDGAAKDKDGYIWILGRVDDVVNVSGHRLSTAEIEAAIIEDPIVAECAVVGFND 611 YF+GDGA +D+DGY WI GRVDDV+NVSGHRL TAEIE+A++ P +AE AVVG Sbjct: 493 KNMYFSGDGARRDEDGYYWITGRVDDVLNVSGHRLGTAEIESALVAHPKIAEAAVVGIPH 552 Query: 612 DLTGQAVAAFVVLKNKSSWSTATDDELQDIKKHLVFTVRKDIGPFAAPKLIILVDDLPKT 671 + GQA+ A+V L + S E+++ VRK+IGP A P ++ D LPKT Sbjct: 553 AIKGQAIYAYVTLNHGEEPSPELYAEVRN-------WVRKEIGPLATPDVLHWTDSLPKT 605 Query: 672 RSGKIMRRILRKILAGESDQLGDVSTLSNPGIVRHLIDS 710 RSGKIMRRILRKI AG++ LGD STL++PG+V L++ Sbjct: 606 RSGKIMRRILRKIAAGDTSNLGDTSTLADPGVVEKLLEE 644 >4WD1-A nrPDB Length = 658 Score = 492 bits (1267), Expect = e-139, Method: Composition-based stats. Identities = 179/659 (27%), Positives = 292/659 (44%), Gaps = 46/659 (6%) Query: 57 RLQPAIATHYSPHLDGLQDYQRLHKESIEDPAKFFGSKATQF-LNWSKPFDKVFIPDPKT 115 R Q A H+ +G Y LH+ S+++ F+ + F + +S P+ +V Sbjct: 24 RFQAWAAEHHGAPAEG--GYAALHRWSVDELDTFWKAVTEWFDVRFSTPYARVL------ 75 Query: 116 GRPSFQNNAWFLNGQLNACYNCVDRHALKTPNKKAIIFEGDEPGQGYSITYKELLEEVCQ 175 G + WF LN + + R A P++ A+++ DE + +T+ EL +V Sbjct: 76 GDRTMPGAQWFPGATLNYAEHAL-RAAGTRPDEPALLYV-DETHEPAPVTWAELRRQVAS 133 Query: 176 VAQVLTYSMGVRKGDTVAVYMPMVPEAIITLLAISRIGAIHSVVFAGFSSNSLRDRINDG 235 +A L ++GVR GD V+ Y+P +P+A++ LLA + +G + + F + S+ DR Sbjct: 134 LAAELR-ALGVRPGDRVSGYLPNIPQAVVALLATAAVGGVWTSCAPDFGARSVLDRFQQV 192 Query: 236 DSKVVITTDESNRGGKVIETKRIVDDALRETPGVRHVLVYRKTNNPSVAFHAPRD-LDWA 294 + V+ T D GGK + + V + RE P +R V+ + P + AP LDW Sbjct: 193 EPVVLFTVDGYRYGGKEHDRRDTVAELRRELPTLRAVI-----HIPLLGTEAPDGTLDWE 247 Query: 295 T-EKKKYKTYYPCTPVDSEDPLFLLYTSGSTGAPKGVQHSTAGYLLGALLTMRYTFDTHQ 353 T + Y P D PL++LY+SG+TG PK + S G L+ L + D Sbjct: 248 TLTAADAEPVYEQVPFDH--PLWVLYSSGTTGLPKAIVQSQGGILVEHLKQLGLHCDLGP 305 Query: 354 EDVFFTAGDIGWITGHTYVVYGPLLYGCATLVFEGTPAYPNYSRYWDIIDEHKVTQFYVA 413 D FF GW+ + LL G ++++G+P +P W I + T F + Sbjct: 306 GDRFFWYTSTGWMM--WNFLVSGLLTGTTIVLYDGSPGFPATDAQWRIAERTGATLFGTS 363 Query: 414 PTALRLLKRAGDSYIENHSLKSLRCLGSVGEPIAAEVWEWYSEKIGKNEIPIVDTYWQTE 473 + ++AG + L +++C+ + G P+ + + W ++ D + + Sbjct: 364 AAYVMACRKAGVHPARDLDLSAIQCVATTGSPLPPDGFRWLHDEFAAGG---ADLWIASV 420 Query: 474 SGSHLVTPLAGGVTPMKP---GSASFPFFGIDAVVLDPNTGEELNTSHAEGVLAVKAAWP 530 SG V G P P G P G D DP +G+ L G L V P Sbjct: 421 SGGTDVCSCFAGAVPTLPVHIGELQAPGLGTDLQSWDP-SGDPLTDEV--GELVVTNPMP 477 Query: 531 SFARTIWKNHD--RYLDTYLNPYPGYYFTGDGAAKDKDGYIWILGRVDDVVNVSGHRLST 588 S W + D RY D+Y + YPG + GD G + I GR D +N G R+ + Sbjct: 478 SMPIRFWNDPDGSRYHDSYFDTYPGVWRHGDWITLTSRGSVVIHGRSDSTLNRQGVRMGS 537 Query: 589 AEIEAAIIEDPIVAECAVVGFNDDLTGQAVAAFVVLKNKSSWSTATDDELQDIKKHLVFT 648 A+I A+ P + E V+G G + FV L ++ DD L D K T Sbjct: 538 ADIYEAVERLPEIRESLVIGIEQPDGGYWMPLFVHLAPGAT----LDDALLDRIKR---T 590 Query: 649 VRKDIGPFAAPKLIILVDDLPKTRSGKIMRRILRKILAGESDQLGDVSTLSNPGIVRHL 707 +R ++ P P +I V +P T +GK + ++++L G + NPG + +L Sbjct: 591 IRVNLSPRHVPDEVIEVPGIPHTLTGKRIEVPVKRLLQGTP-----LDKAVNPGSIDNL 644 >3ETC-A nrPDB Length = 580 Score = 462 bits (1189), Expect = e-130, Method: Composition-based stats. Identities = 161/607 (26%), Positives = 265/607 (43%), Gaps = 53/607 (8%) Query: 84 IEDPAKFFGSKATQFLNWSKPFDKVFIPDPKTGRPSFQNNAWFLNGQ-LNACYNCVDRHA 142 I+D K S +QF++ F+ FQ N L + N Y+ VD +A Sbjct: 17 IDDDDKHMTSLLSQFVS-KTDFESYED---------FQENFKILVPENFNFAYDVVDVYA 66 Query: 143 LKTPNKKAIIFEGDEPGQGYSITYKELLEEVCQVAQVLTYSMGVRKGDTVAVYMPMVPEA 202 +P K A+I+ D+ G T+K+L + A G+ KGD V + + + Sbjct: 67 RDSPEKLAMIW-CDDYGNEKIFTFKDLKYYSDKAANFFV-KHGIGKGDYVMLTLKSRYDF 124 Query: 203 IITLLAISRIGAIHSVVFAGFSSNSLRDRINDGDSKVVITTDESNRGGKVIETKRIVDDA 262 +L + ++GAI + + RI K+++ E + VD+A Sbjct: 125 WYCMLGLHKLGAIAVPATHMLKTRDIVYRIEKAGLKMIVCIAED-------DVPEQVDEA 177 Query: 263 LRETPGVRHVLVYRKTNNPSVAFHAPRDLDWATEKKKYKTYYPCTPVDS--EDPLFLLYT 320 E + +K D E+ P V + ED + ++ Sbjct: 178 HAECGDIP----LKKAKVGGDVLEGWIDFRKELEESSPIFERPTGEVSTKNEDICLVYFS 233 Query: 321 SGSTGAPKGVQHSTAGYLLGALLTMRYTFDTHQEDVFFTAGDIGWITGHTYVVYGPLLYG 380 SG+ G PK V+H Y LG +LT +Y + + + +T D GW +YG + G Sbjct: 234 SGTAGFPKMVEHDNT-YPLGHILTAKYWQNVEDDGLHYTVADSGWGKCVWGKLYGQWIAG 292 Query: 381 CATLVFEGTPAYPNYSRYWDIIDEHKVTQFYVAPTALRLLKRAGDSYIENHSLKSLRCLG 440 CA V++ + ++ VT F PT R L + + +++ +L+ Sbjct: 293 CAVFVYD--YDRFEAKNMLEKASKYGVTTFCAPPTIYRFLIKED---LSHYNFSTLKYAV 347 Query: 441 SVGEPIAAEVWEWYSEKIGKNEIPIVDTYWQTESGSHLVTPLAGGVTPMKPGSASFPFFG 500 GEP+ EV+ + E G I +++ + QTE+ +VT KPGS P G Sbjct: 348 VAGEPLNPEVFNRFLEFTG---IKLMEGFGQTET---VVTIATFPWMEPKPGSIGKPTPG 401 Query: 501 IDAVVLDPNTGEELNTSHAEGVLAV---KAAWPSFARTIWKNHDRYLDTYLNPYPGYYFT 557 ++D + L EG + + + K+ +R +T + GYY T Sbjct: 402 YKIELMDRDGR--LCEVGEEGEIVINTMEGKPVGLFVHYGKDPERTEET---WHDGYYHT 456 Query: 558 GDGAAKDKDGYIWILGRVDDVVNVSGHRLSTAEIEAAIIEDPIVAECAVVGFNDDLTGQA 617 GD A D+DGY+W +GR DD++ SG+++ E+E+A+I+ P V ECA+ G D + GQ Sbjct: 457 GDMAWMDEDGYLWFVGRADDIIKTSGYKVGPFEVESALIQHPAVLECAITGVPDPVRGQV 516 Query: 618 VAAFVVLKNKSSWSTATDDELQDIKKHLVFTVRKDIGPFAAPKLIILVDDLPKTRSGKIM 677 + A +VL + S + +ELQD K++ P+ P++I V +LPKT SGKI Sbjct: 517 IKATIVLTKDYTPSDSLKNELQDHVKNVT-------APYKYPRIIEFVPELPKTISGKIR 569 Query: 678 RRILRKI 684 R +R Sbjct: 570 RVEIRDK 576 >4WV3-A nrPDB Length = 529 Score = 430 bits (1104), Expect = e-120, Method: Composition-based stats. Identities = 139/551 (25%), Positives = 216/551 (39%), Gaps = 48/551 (8%) Query: 135 YNCVD--RHALKTPNKKAIIFEGDEPGQGYSITYKELLEEVCQVAQVLTYSMGVRKGDTV 192 YN VD L K +F D +T++++ E QV L +GVR G+ V Sbjct: 10 YNAVDILERNLPVRANKTALFTPDR-----EMTFRQVSNEANQVGNAL-KGLGVRFGECV 63 Query: 193 AVYMPMVPEAIITLLAISRIGAIHSVVFAGFSSNSLRDRINDGDSKVVITTDESNRGGKV 252 + E + + I ++GAI + + D ++V+I E Sbjct: 64 GLLTLDSAEWVTSFFGIVKLGAIAVGINTLLKPPEYEYILRDCRARVLIVHQEFLP---- 119 Query: 253 IETKRIVDDALRETPGVRHVLVYRKTNNPSVAFHAPRDLDWATEKKKYKTYYPCTPVDSE 312 +++ P + H++V + DW + T E Sbjct: 120 -----LIESIRGNLPMLEHIVVIGEGPQEG----YLSFNDWI---RPQPTTLEAAQSHRE 167 Query: 313 DPLFLLYTSGSTGAPKGVQHSTAGYLLGALLTMRYTFDTHQEDVFFTAGDIGWITGHTYV 372 D L Y+SG+TG PKG+ H+ Y L A L + D F + + G Sbjct: 168 DICSLNYSSGTTGGPKGIPHAHKDYPLTAQLWGVNVLGLRESDRTFALAKLFFTFGTGGN 227 Query: 373 VYGPLLYGCATLVFEGTPAYPNYSRYWDIIDEHKVTQFYVAPTALRLLKRAGDSYIENHS 432 + P G + ++F G A S I K T FY APT D H Sbjct: 228 LIFPWYVGASCVLFPG--AARVASNVLSTISRFKPTIFYNAPTGYAAALALKD--FSQHD 283 Query: 433 LKSLRCLGSVGEPIAAEVWEWYSEKIGKNEIPIVDTYWQTESGSHLVTPLAGGVTPMKPG 492 L SLR S E + A +W + E G + I+D TE+ ++ G ++PG Sbjct: 284 LSSLRLCVSASEALPAALWYAWKEATG---VDIIDGIGCTENFHIFISNRPGD---IRPG 337 Query: 493 SASFPFFGIDAVVLDPNTGEELNTSHAEGVLAVKAAWPSFARTIWKNHDRYLDTYLNPYP 552 S+ P G + ++D V + A + W N ++ T+ Sbjct: 338 SSGKPVEGYELKLVDDEGKTVPAGEIG----NVLLRSETAALSYWHNFEKSRQTFQGE-- 391 Query: 553 GYYFTGDGAAKDKDGYIWILGRVDDVVNVSGHRLSTAEIEAAIIEDPIVAECAVVGFNDD 612 + TGD D DGY W GR DD++ V G +S E+E+ +I+ P V ECAV+G D Sbjct: 392 -WLATGDKYFVDADGYYWHAGRSDDMLKVGGIWVSPVEVESTLIQHPAVQECAVIGCPDQ 450 Query: 613 LTGQAVAAFVVLKNKSSWSTATDDELQDIKKHLVFTVRKDIGPFAAPKLIILVDDLPKTR 672 AF++LK + S A + + + + + + P+ I V +LPKT Sbjct: 451 SRLIKPKAFIILKPEQIPSEA-------LIRQITDHCTEKMAAYKRPRWIEFVTELPKTA 503 Query: 673 SGKIMRRILRK 683 +GKI R LR Sbjct: 504 TGKIQRFKLRS 514 >3GPC-A nrPDB Length = 570 Score = 426 bits (1095), Expect = e-119, Method: Composition-based stats. Identities = 148/563 (26%), Positives = 243/563 (43%), Gaps = 45/563 (7%) Query: 129 GQLNACYNCVD-----RHALKTPNKKAIIFEGDEPGQGYSITYKELLEEVCQVAQVLTYS 183 + N + +D A K P A+ + + G+ ++EL E Q A VL+ + Sbjct: 35 AKFNFASDVLDHWADMEKAGKRPPSPALWWVNGK-GKELMWNFRELSENSQQAANVLSGA 93 Query: 184 MGVRKGDTVAVYMPMVPEAIITLLAISRIGAIHSVVFAGFSSNSLRDRINDGDSKVVITT 243 G+++GD VAV +P VPE + +L R G I S + R+ +K ++ Sbjct: 94 CGLQRGDRVAVVLPRVPEWWLVILGCIRAGLIFMPGTIQMKSTDILYRLQMSKAKAIVAG 153 Query: 244 DESNRGGKVIETKRIVDDALRETPGVR-HVLVYRKTNNPSVAFHAPRDLDWATEKKKYKT 302 DE + VD E P +R +LV K+ + + F + T Sbjct: 154 DE---------VIQEVDTVASECPSLRIKLLVSEKSCDGWLNFKKL--------LNEAST 196 Query: 303 YYPCTPVDSEDPLFLLYTSGSTGAPKGVQHSTAGYLLGALLTMRYTFDTHQEDVFFTAGD 362 + C S++ + +TSG++G PK +HS + L A + +T D+ +T D Sbjct: 197 THHCVETGSQEASAIYFTSGTSGLPKMAEHSYSSLGLKAKMDAGWT-GLQASDIMWTISD 255 Query: 363 IGWITGHTYVVYGPLLYGCATLVFEGTPAYPNYSRYWDIIDEHKVTQFYVAPTALRLLKR 422 GWI + P G T V + + + + AP R+L + Sbjct: 256 TGWILNILCSLMEPWALGACTFVHLLPKF--DPLVILKTLSSYPIKSMMGAPIVYRMLLQ 313 Query: 423 AGDSYIENHSLKSLRCLGSVGEPIAAEVWEWYSEKIGKNEIPIVDTYWQTESGSHLVTPL 482 + ++ L+ +VGE + E E + + G + I ++Y QTE+G +T + Sbjct: 314 QD---LSSYKFPHLQNCVTVGESLLPETLENWRAQTG---LDIRESYGQTETG---LTCM 364 Query: 483 AGGVTPMKPGSASFPFFGIDAVVLDPNTGEELNTSHAEGVLAVKAAWPSFARTIWKNH-D 541 +KPG D ++D + G L EG + ++ P I+ + D Sbjct: 365 VSKTMKIKPGYMGTAASCYDVQIID-DKGNVLPPG-TEGDIGIRVK-PIRPIGIFSGYVD 421 Query: 542 RYLDTYLNPYPGYYFTGDGAAKDKDGYIWILGRVDDVVNVSGHRLSTAEIEAAIIEDPIV 601 T N ++ GD KD+DGY +GR DD++N SG+R+ +E+E A++E P V Sbjct: 422 NPDKTAANIRGDFWLLGDRGIKDEDGYFQFMGRADDIINSSGYRIGPSEVENALMEHPAV 481 Query: 602 AECAVVGFNDDLTGQAVAAFVVLKNKSSWSTATDDELQDIKKHLVFTVRKDIGPFAAPKL 661 E AV+ D + G+ V AFVVL S + + + K L V+ P+ P+ Sbjct: 482 VETAVISSPDPVRGEVVKAFVVLA-----SQFLSHDPEQLTKELQQHVKSVTAPYKYPRK 536 Query: 662 IILVDDLPKTRSGKIMRRILRKI 684 I V +LPKT +GKI R LR Sbjct: 537 IEFVLNLPKTVTGKIQRAKLRDK 559 >3TSY-A nrPDB Length = 979 Score = 415 bits (1067), Expect = e-116, Method: Composition-based stats. Identities = 127/534 (23%), Positives = 221/534 (41%), Gaps = 44/534 (8%) Query: 160 QGYSITYKELLEEVCQVAQVLTYSMGVRKGDTVAVYMPMVPEAIITLLAISRIGAIHSVV 219 G+ TY ++ Q+A + +GV + D V + +P PE +++ LA S GA + Sbjct: 85 TGHVYTYSDVHVISRQIAANF-HKLGVNQNDVVMLLLPNCPEFVLSFLAASFRGATATAA 143 Query: 220 FAGFSSNSLRDRINDGDSKVVITTDESNRGGKVIETKRIVDDA--LRETPGVRHVLVYRK 277 F+ + + ++K++IT R VD L+ GV V + Sbjct: 144 NPFFTPAEIAKQAKASNTKLIITE------------ARYVDKIKPLQNDDGVVIVCIDDN 191 Query: 278 TNNPSVAFHAPRDLDWATEKKKYKTYYPCTPVDSEDPLFLLYTSGSTGAPKGVQHSTAGY 337 + P + R + + + +D + L Y+SG+TG PKGV + G Sbjct: 192 ESVP-IPEGCLRFTELTQSTTEASEVIDSVEISPDDVVALPYSSGTTGLPKGVMLTHKGL 250 Query: 338 LLGALLTMR---YTFDTHQEDVFFTAGDIGWITGHTYVVYGPLLYGCATLVFEGTPAYPN 394 + + H +DV + I ++ L G A L+ Sbjct: 251 VTSVAQQVDGENPNLYFHSDDVILCVLPMFHIYALNSIMLCGLRVGAAILIMPKF----E 306 Query: 395 YSRYWDIIDEHKVTQFYVAPTALRLLKRAGDSYIENHSLKSLRCLGSVGEPIAAEVWEWY 454 + ++I KVT + P + L A S E + L S+R + S P+ E+ + Sbjct: 307 INLLLELIQRCKVTVAPMVPPIV--LAIAKSSETEKYDLSSIRVVKSGAAPLGKELEDAV 364 Query: 455 SEKIGKNEIPIVDTYWQTESGSHLVTPL--AGGVTPMKPGSASFPFFGIDAVVLDPNTGE 512 + K ++ Y TE+G L L A P+K G+ + ++DP+TG+ Sbjct: 365 NAKFPNAKLG--QGYGMTEAGPVLAMSLGFAKEPFPVKSGACGTVVRNAEMKIVDPDTGD 422 Query: 513 ELNTSHAEGVLAVKAAWPSFARTIWKNHDRYLDTYLNPYPGYYFTGDGAAKDKDGYIWIL 572 L+ + G + ++ + N +T G+ TGD D D ++I+ Sbjct: 423 SLSRNQP-GEICIRG--HQIMKGYLNNPAATAET--IDKDGWLHTGDIGLIDDDDELFIV 477 Query: 573 GRVDDVVNVSGHRLSTAEIEAAIIEDPIVAECAVVGFNDDLTGQAVAAFVVLKNKSSWST 632 R+ +++ G +++ AE+EA +I P + + AVV ++ G+ AFVV S S Sbjct: 478 DRLKELIKYKGFQVAPAELEALLIGHPDITDVAVVAMKEEAAGEVPVAFVVKSKDSELSE 537 Query: 633 ATDDELQDIKKHLVFTVRKDIGPFAAPKLIILVDDLPKTRSGKIMRRILRKILA 686 DD Q + K +VF R + + + +PK SGKI+R+ LR LA Sbjct: 538 --DDVKQFVSKQVVFYKRIN--------KVFFTESIPKAPSGKILRKDLRAKLA 581 >3A9U-A nrPDB Length = 536 Score = 415 bits (1066), Expect = e-116, Method: Composition-based stats. Identities = 129/534 (24%), Positives = 224/534 (41%), Gaps = 48/534 (8%) Query: 159 GQGYSITYKELLEEVCQVAQVLTYSMGVRKGDTVAVYMPMVPEAIITLLAISRIGAIHSV 218 G TY ++ +VA L +G+++GD + +++P PE ++ L S GAI + Sbjct: 45 ANGDVYTYADVELTARRVASGL-NKIGIQQGDVIMLFLPSSPEFVLAFLGASHRGAIITA 103 Query: 219 VFAGFSSNSLRDRINDGDSKVVITTDESNRGGKVIETKRIVDDALRETPGVRHVLVYRKT 278 + L +K++IT ++ KV + R D V V Sbjct: 104 ANPFSTPAELAKHAKASRAKLLIT--QACYYEKVKDFARESD-----------VKVMCVD 150 Query: 279 NNPSVAFHAPRDLDWATEKKKYKTYYPCTPVDSEDPLFLLYTSGSTGAPKGVQHSTAGYL 338 + P H + P + +D + L Y+SG+TG PKGV + G + Sbjct: 151 SAPDGCLHFSELTQADENEA------PQVDISPDDVVALPYSSGTTGLPKGVMLTHKGLI 204 Query: 339 LGALLTMR---YTFDTHQEDVFFTAGDIGWITGHTYVVYGPLLYGCATLVFEGTPAYPNY 395 + H EDV + I ++ L G L+ Sbjct: 205 TSVAQQVDGDNPNLYFHSEDVILCVLPMFHIYALNSIMLCGLRVGAPILIMPKF----EI 260 Query: 396 SRYWDIIDEHKVTQFYVAPTALRLLKRAGDSYIENHSLKSLRCLGSVGEPIAAEVWEWYS 455 +I+++KV+ V P + + ++ D ++ H L SLR + S G P+ E+ + Sbjct: 261 GSLLGLIEKYKVSIAPVVPPVMMSIAKSPD--LDKHDLSSLRMIKSGGAPLGKELEDTVR 318 Query: 456 EKIGKNEIPIVDTYWQTESGSHLVTPLAGGVTP--MKPGSASFPFFGIDAVVLDPNTGEE 513 K + + Y TE+G L LA P +KPG+ + ++DP TG Sbjct: 319 AKFPQARLG--QGYGMTEAGPVLAMCLAFAKEPFDIKPGACGTVVRNAEMKIVDPETGAS 376 Query: 514 LNTSHAEGVLAVKAAWPSFARTIWKNHDRYLDTYLNPYPGYYFTGDGAAKDKDGYIWILG 573 L + G + ++ + + + T G+ TGD D D ++I+ Sbjct: 377 LPRNQP-GEICIRGDQ--IMKGYLNDPEATSRT--IDKEGWLHTGDIGYIDDDDELFIVD 431 Query: 574 RVDDVVNVSGHRLSTAEIEAAIIEDPIVAECAVVGFNDDLTGQAVAAFVVLKNKSSWSTA 633 R+ +++ G +++ AE+EA +I P +++ AVVG D+ G+ AFVV KS S A Sbjct: 432 RLKELIKYKGFQVAPAELEALLIAHPEISDAAVVGLKDEDAGEVPVAFVV---KSEKSQA 488 Query: 634 TDDELQDIKKHLVFTVRKDIGPFAAPKLIILVDDLPKTRSGKIMRRILRKILAG 687 T+DE++ V + K + ++ +PK SGKI+R+ L++ LAG Sbjct: 489 TEDEIKQYISKQVIF-------YKRIKRVFFIEAIPKAPSGKILRKNLKEKLAG 535 >5BSW-A nrPDB Length = 541 Score = 409 bits (1050), Expect = e-114, Method: Composition-based stats. Identities = 118/534 (22%), Positives = 226/534 (42%), Gaps = 49/534 (9%) Query: 159 GQGYSITYKELLEEVCQVAQVLTYSMGVRKGDTVAVYMPMVPEAIITLLAISRIGAIHSV 218 TY ++ +VA L + G++ DT+ + +P PE + + S +GAI ++ Sbjct: 48 ANKQIYTYADVELNSRKVAAGL-HKQGIQPKDTIMILLPNSPEFVFAFIGASYLGAISTM 106 Query: 219 VFAGFSSNSLRDRINDGDSKVVITTDESNRGGKVIETKRIVDDALRETPGVRHVLVYRKT 278 F+ + + +K+++T + ++ D A + + + Sbjct: 107 ANPLFTPAEVVKQAKASSAKIIVT--------QACHVNKVKDYAFENDVKIICIDSAPEG 158 Query: 279 NNPSVAFHAPRDLDWATEKKKYKTYYPCTPVDSEDPLFLLYTSGSTGAPKGVQHSTAGYL 338 L ++ + + P + +D + L Y+SG+TG PKGV + G + Sbjct: 159 C-----------LHFSVLTQANEHDIPEVEIQPDDVVALPYSSGTTGLPKGVMLTHKGLV 207 Query: 339 LGALLTMR---YTFDTHQEDVFFTAGDIGWITGHTYVVYGPLLYGCATLVFEGTPAYPNY 395 + H EDV + I V+ L G A L+ + + Sbjct: 208 TSVAQQVDGENPNLYIHSEDVMLCVLPLFHIYSLNSVLLCGLRVGAAILIMQKF----DI 263 Query: 396 SRYWDIIDEHKVTQFYVAPTALRLLKRAGDSYIENHSLKSLRCLGSVGEPIAAEVWEWYS 455 + ++I +KVT P + + ++ ++++ L S+R + S P+ E+ + Sbjct: 264 VSFLELIQRYKVTIGPFVPPIVLAIAKSP--MVDDYDLSSVRTVMSGAAPLGKELEDTVR 321 Query: 456 EKIGKNEIPIVDTYWQTESGSHLVTPLAGGVTP--MKPGSASFPFFGIDAVVLDPNTGEE 513 K ++ Y TE+G L LA P +K G+ + ++DP TG Sbjct: 322 AKFPNAKLG--QGYGMTEAGP-LAMCLAFAKEPFEIKSGACGTVVRNAEMKIVDPKTGNS 378 Query: 514 LNTSHAEGVLAVKAAWPSFARTIWKNHDRYLDTYLNPYPGYYFTGDGAAKDKDGYIWILG 573 L + + G + ++ + + + T G+ +TGD D D ++I+ Sbjct: 379 LPRNQS-GEICIRGDQ--IMKGYLNDPEATART--IDKEGWLYTGDIGYIDDDDELFIVD 433 Query: 574 RVDDVVNVSGHRLSTAEIEAAIIEDPIVAECAVVGFNDDLTGQAVAAFVVLKNKSSWSTA 633 R+ +++ G +++ AE+EA ++ P +++ AVV D+ G+ AFVV +S+ ST Sbjct: 434 RLKELIKYKGFQVAPAELEALLLNHPNISDAAVVPMKDEQAGEVPVAFVV---RSNGSTI 490 Query: 634 TDDELQDIKKHLVFTVRKDIGPFAAPKLIILVDDLPKTRSGKIMRRILRKILAG 687 T+DE++D V + K + VD +PK+ SGKI+R+ LR LA Sbjct: 491 TEDEVKDFISKQVIF-------YKRIKRVFFVDAIPKSPSGKILRKDLRAKLAA 537 >3R44-A nrPDB Length = 517 Score = 407 bits (1045), Expect = e-113, Method: Composition-based stats. Identities = 130/547 (23%), Positives = 225/547 (41%), Gaps = 58/547 (10%) Query: 137 CVDRHALKTPNKKAIIFEGDEPGQGYSITYKELLEEVCQVAQVLTYSMGVRKGDTVAVYM 196 + + A +P +A + EP +TY ++ + A VLT ++G+ KGD VA+ M Sbjct: 21 MLRQRATVSPRLQAYV----EPSTDVRMTYAQMNALANRCADVLT-ALGIAKGDRVALLM 75 Query: 197 PMVPEAIITLLAISRIGAIHSVVFAGFSSNSLRDRINDGDSKVVITTDESNRGGKVIETK 256 P E +++GA+ + ++ + ++D SKVVI S VI+ Sbjct: 76 PNSVEFCCLFYGAAKLGAVAVPINTRLAAPEVSFILSDSGSKVVIYGAPS---APVIDAI 132 Query: 257 RIVDDALRETPGVRHVLVYRKTNNPSVAFHAPRDLDWATEKKKYKTYYPCTPVDSEDPLF 316 R A + PG + + A + P +D LF Sbjct: 133 R----AQADPPGTVTDWIGADS--------------LAERLRSAAADEPAVECGGDDNLF 174 Query: 317 LLYTSGSTGAPKGVQHSTAGYLLGALLTMRYTFDTHQEDVFFTAGDIGWITGHTYVVYGP 376 ++YTSG+TG PKGV H+ + A + T D D + + T V++ Sbjct: 175 IMYTSGTTGHPKGVVHTHES-VHSAASSWASTIDVRYRDRLLLPLPMFHVAALTTVIFSA 233 Query: 377 LLYGCATLVFEGTPAYPNYSRYWDIIDEHKVTQFYVAPTALRLLKRAGDSYIENHSLKSL 436 + + P + + ++ W +I E +V P L +++ + Sbjct: 234 MRG----VTLISMPQF-DATKVWSLIVEERVCIGGAVPAILNFMRQVPE--FAELDAPDF 286 Query: 437 RCLGSVGEPIAAEVWEWYSEKIGKNEIPIVDTYWQTESGSHLVTPLAGGVTPMKPGSASF 496 R + G P+ + + Y+ K I +V Y TES L+ K GSA Sbjct: 287 RYFITGGAPMPEALIKIYAAK----NIEVVQGYALTESCGGGTLLLSEDAL-RKAGSAGR 341 Query: 497 PFFGIDAVVLDPNTGEELNTSHAEGVLAVKAAWPSFARTIWKNHDRYLDTYLNPYPGYYF 556 D V + + H EG + +K + W + D + N G++ Sbjct: 342 ATMFTDVAVRGDDG---VIREHGEGEVVIK--SDILLKEYWNRPEATRDAFDN---GWFR 393 Query: 557 TGDGAAKDKDGYIWILGRVDDVVNVSGHRLSTAEIEAAIIEDPIVAECAVVGFNDDLTGQ 616 TGD D +GY++I R+ D++ G + AEIE+ II P V+E AV+G D+ G+ Sbjct: 394 TGDIGEIDDEGYLYIKDRLKDMIISGGENVYPAEIESVIIGVPGVSEVAVIGLPDEKWGE 453 Query: 617 AVAAFVVLKNKSSWSTATDDELQDIKKHLVFTVRKDIGPFAAPKLIILVDDLPKTRSGKI 676 AA VV A +E+ + + +V + + PK +I + +P+ +GKI Sbjct: 454 IAAAIVV---------ADQNEVSE--QQIVEYCGTRLARYKLPKKVIFAEAIPRNPTGKI 502 Query: 677 MRRILRK 683 ++ +LR+ Sbjct: 503 LKTVLRE 509 >5IE2-A nrPDB Length = 514 Score = 407 bits (1044), Expect = e-113, Method: Composition-based stats. Identities = 122/545 (22%), Positives = 238/545 (43%), Gaps = 47/545 (8%) Query: 137 CVDRHALKTPNKKAIIFEGDEPGQGYSITYKELLEEVCQVAQVLTYSMGVRKGDTVAVYM 196 ++ A K P+++A+ G +++T+ L + + + A L G++ GD VA+ Sbjct: 9 LLENVAKKFPDRRALSVSGK-----FNLTHARLHDLIERAASRLVSDAGIKPGDVVALTF 63 Query: 197 PMVPEAIITLLAISRIGAIHSVVFAGFSSNSLRDRINDGDSKVVITTDESNRGGKVIETK 256 P E +I LA+ R A + + A +++ ++D DSK+++T+ E N + +K Sbjct: 64 PNTVEFVIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLLLTSKEGNAPAQEAASK 123 Query: 257 RIVDDALRETPGVRHVLVYRKTNNPSVAFHAPRDLDWATEKKKYKTYYPCTPVDSEDPLF 316 + LV ++ SV +D ATE + +D Sbjct: 124 LKISHVTATLLDAGSDLVLSVADSDSV-------VDSATELVNH----------PDDGAL 166 Query: 317 LLYTSGSTGAPKGVQHSTAGYLLGALLTMRYTFDTHQEDVFFTAGDIGWITGHTYVVYGP 376 L+TSG+T PKGV + L ++ ++ + + D + + H + Sbjct: 167 FLHTSGTTSRPKGVPLTQLN-LASSVKNIKAVYKLTESDSTVIVLPLFHV--HGLLAGLL 223 Query: 377 LLYGCATLVFEGTPAYPNYSRYWDIIDEHKVTQFYVAPTALRLLKRAGDSYIENHSLKSL 436 G V + + +W + ++ T + PT +++ S+ E K L Sbjct: 224 SSLGAGAAVTLPAAGRFSATTFWPDMKKYNATWYTAVPTIHQIILDRHASHPETEYPK-L 282 Query: 437 RCLGSVGEPIAAEVWEWYSEKIGKNEIPIVDTYWQTESGSHLVTPLAGGVTPMKPGSASF 496 R + S +A + E G P+++ Y TE+ + + P KPGS Sbjct: 283 RFIRSCSASLAPVILSRLEEAFGA---PVLEAYAMTEATHLMSSNPLPEEGPHKPGSVGK 339 Query: 497 PFFGIDAVVLDPNTGEELNTSHAEGVLAVKAAWPSFARTIWKNHDRYLDTYLNPYPGYYF 556 P G + +L N E+ + +G + ++ P+ + N + + G++ Sbjct: 340 PV-GQEMAIL--NEKGEIQEPNNKGEVCIRG--PNVTKGYKNNPEANKAGFEF---GWFH 391 Query: 557 TGDGAAKDKDGYIWILGRVDDVVNVSGHRLSTAEIEAAIIEDPIVAECAVVGFNDDLTGQ 616 TGD D DGY+ ++GR+ +++N G ++S E++A ++ P V++ G D+ G+ Sbjct: 392 TGDIGYFDTDGYLHLVGRIKELINRGGEKISPIEVDAVLLTHPDVSQGVAFGVPDEKYGE 451 Query: 617 AVAAFVVLKNKSSWSTATDDELQDIKKHLVFTVRKDIGPFAAPKLIILVDDLPKTRSGKI 676 + V+ + +T T+++++ +K++ F PK + + D+LPKT SGKI Sbjct: 452 EINCAVIPREG---TTVTEEDIKAF-------CKKNLAAFKVPKRVFITDNLPKTASGKI 501 Query: 677 MRRIL 681 RRI+ Sbjct: 502 QRRIV 506 >4EAT-A nrPDB Length = 524 Score = 397 bits (1020), Expect = e-111, Method: Composition-based stats. Identities = 137/562 (24%), Positives = 237/562 (42%), Gaps = 47/562 (8%) Query: 127 LNGQLNACYNCVDRHALKTPNKKAIIFEGDEPGQGYSITYKELLEEVCQVAQVLTYSMGV 186 + N + + + P+K A + D+ S+++ +L + Q+A L ++GV Sbjct: 9 PPEKFNFAEHLL-QTNRVRPDKTAFV---DDIS---SLSFAQLEAQTRQLAAALR-AIGV 60 Query: 187 RKGDTVAVYMPMVPEAIITLLAISRIGAIHSVVFAGFSSNSLRDRINDGDSKVVITTDES 246 ++ + V + M + + L G + V +++ + ++ V+ + Sbjct: 61 KREERVLLLMLDGTDWPVAFLGAIYAGIVPVAVNTLLTADDYAYMLEHSRAQAVLVS--- 117 Query: 247 NRGGKVIETKRIVDDALRETPGVRHVLVYRKTNNPSVAFHAPRDLDWATEKKKYKTYYPC 306 G + + + V+ V+V R P+ P ++D+A + Sbjct: 118 ---GALHPVLK--AALTKSDHEVQRVIVSR----PAAPLE-PGEVDFAEFVGAHAPLEKP 167 Query: 307 TPVDSEDPLFLLYTSGSTGAPKGVQHSTAGYLLGALLTMRYTFDTHQEDVFFTAGDIGWI 366 ++DP F LY+SGSTG PKGV H+ A + L R T ++DV F+A + + Sbjct: 168 AATQADDPAFWLYSSGSTGRPKGVVHTHANPYWTSELYGRNTLHLREDDVCFSAAKLFFA 227 Query: 367 TGHTYVVYGPLLYGCATLVFEGTPAY-PNYSRYWDIIDEHKVTQFYVAPTALRLLKRAGD 425 G + P+ G TL+ P + R+ + K T FY APT + A + Sbjct: 228 YGLGNALTFPMTVGATTLLMGERPTPDAVFKRWLGGVGGVKPTVFYGAPTGYAGMLAAPN 287 Query: 426 SYIENHSLKSLRCLGSVGEPIAAEVWEWYSEKIGKNEIPIVDTYWQTESGSHLVTPLAGG 485 + + +LR S GE + AE+ + + G + IVD TE ++ L Sbjct: 288 --LPSRDQVALRLASSAGEALPAEIGQRFQRHFG---LDIVDGIGSTEMLHIFLSNLPDR 342 Query: 486 VTPMKPGSASFPFFGIDAVVLDPNTGEELNTSHAEGVLAVKAAWPSFARTIWKNHDRYLD 545 V + G+ +P G + G + G L + PS A W N + D Sbjct: 343 V---RYGTTGWPVPGYQIELRGDGGGPVADGEP--GDLYIHG--PSSATMYWGNRAKSRD 395 Query: 546 TYLNPYPGYYFTGDGAAKDKDGYIWILGRVDDVVNVSGHRLSTAEIEAAIIEDPIVAECA 605 T+ G+ +GD ++ DG GR DD++ VSG +S EIEA +++ P V E A Sbjct: 396 TFQG---GWTKSGDKYVRNDDGSYTYAGRTDDMLKVSGIYVSPFEIEATLVQHPGVLEAA 452 Query: 606 VVGFNDDLTGQAVAAFVVLKNKSSWSTATDDELQDIKKHLVFTVRKDIGPFAAPKLIILV 665 VVG D+ A+VV + + S L ++ + P+ P+ + V Sbjct: 453 VVGVADEHGLTKPKAYVVPRPGQTLSE----------TELKTFIKDRLAPYKYPRSTVFV 502 Query: 666 DDLPKTRSGKIMRRILRKILAG 687 +LPKT +GKI R LR+ + G Sbjct: 503 AELPKTATGKIQRFKLREGVLG 524 >5BUS-A nrPDB Length = 494 Score = 393 bits (1009), Expect = e-109, Method: Composition-based stats. Identities = 126/562 (22%), Positives = 228/562 (40%), Gaps = 79/562 (14%) Query: 129 GQLNACYNCVDRHALKTPNKKAIIFEGDEPGQGYSITYKELLEEVCQVAQVLTYSMGVRK 188 G L N + + A TP + A+I+E ++T+ EL ++A+ L + VRK Sbjct: 2 GMLTEQPNWLMQRAQLTPERIALIYEDQ------TVTFAELFAASKRMAEQLA-AHSVRK 54 Query: 189 GDTVAVYMPMVPEAIITLLAISRIGAIHSVVFAGFSSNSLRDRINDGDSKVVITTD--ES 246 GDT A+ + E + + A +G ++ S++ ++ D S ++T E Sbjct: 55 GDTAAILLQNRAEMVYAVHACFLLGVKAVLLNTKLSTHERLFQLEDSGSGFLLTDSSFEK 114 Query: 247 NRGGKVIETKRIVDDALRETPGVRHVLVYRKTNNPSVAFHAPRDLDWATEKKKYKTYYPC 306 +++T VD+ ++E + Y + + Sbjct: 115 KEYEHIVQTID-VDELMKEAAEEIEIEAYMQMDAT------------------------- 148 Query: 307 TPVDSEDPLFLLYTSGSTGAPKGVQHSTAGYLLGALLTMRYTFDTHQEDVFFTAGDIGWI 366 L+YTSG+TG PKGVQ + + A+ + ++D + A + I Sbjct: 149 --------ATLMYTSGTTGKPKGVQQTFGNHYFSAVSSA-LNLGITEQDRWLIALPLFHI 199 Query: 367 TGHTYVVYGPLLYGCATLVFEGTPAYPNYSRYWDIIDEHKVTQFYVAPTALRLLKRAGDS 426 +G + ++ ++YG ++ + S I+ H+VT T L L Sbjct: 200 SGLS-ALFKSVIYGMTVVLHQRFSV----SDVLHSINRHEVTMISAVQTMLASLLEE--- 251 Query: 427 YIENHSLKSLRCLGSVGEPIAAEVWEWYSEKIGKNEIPIVDTYWQTESGSHLVTPLAGGV 486 N +S+RC+ G P + E EK P+ +Y TE+ S +VT L+ Sbjct: 252 --TNRCPESIRCILLGGGPAPLPLLEECREK----GFPVFQSYGMTETCSQIVT-LSPEF 304 Query: 487 TPMKPGSASFPFFGIDAVVLDPNTGEELNTSHAEGVLAVKAAWPSFARTIWKNHDRYLDT 546 + K GSA P F + + + + G + VK P+ ++ + + Sbjct: 305 SMEKLGSAGKPLFSCEIKIERDGQ---VCEPYEHGEIMVKG--PNVMKSYFNRESANEAS 359 Query: 547 YLNPYPGYYFTGDGAAKDKDGYIWILGRVDDVVNVSGHRLSTAEIEAAIIEDPIVAECAV 606 + N G+ TGD D +G++++L R D++ G + AE+E+ ++ P VAE V Sbjct: 360 FQN---GWLKTGDLGYLDNEGFLYVLDRRSDLIISGGENIYPAEVESVLLSHPAVAEAGV 416 Query: 607 VGFNDDLTGQAVAAFVVLKNKSSWSTATDDELQDIKKHLVFTVRKDIGPFAAPKLIILVD 666 G D G+ A++VL S TD ++ + + P ++D Sbjct: 417 SGAEDKKWGKVPHAYLVLHKPVSAGELTD------------YCKERLAKYKIPAKFFVLD 464 Query: 667 DLPKTRSGKIMRRILRKILAGE 688 LP+ S K++R L+ GE Sbjct: 465 RLPRNASNKLLRNQLKDARKGE 486 >4FUQ-A nrPDB Length = 503 Score = 389 bits (999), Expect = e-108, Method: Composition-based stats. Identities = 136/541 (25%), Positives = 221/541 (40%), Gaps = 57/541 (10%) Query: 143 LKTPNKKAIIFEGDEPGQGYSITYKELLEEVCQVAQVLTYSMGVRKGDTVAVYMPMVPEA 202 L P+K AI E G I+Y EL+ +VA VL + G++ GD VA EA Sbjct: 13 LDDPHKLAI-----ETAAGDKISYAELVARAGRVANVLV-ARGLQVGDRVAAQTEKSVEA 66 Query: 203 IITLLAISRIGAIHSVVFAGFSSNSLRDRINDGDSKVVITTDESNRGGKVIETKRIVDDA 262 ++ LA R G ++ + ++ + L I D + K+V+ D S R G ++ Sbjct: 67 LVLYLATVRAGGVYLPLNTAYTLHELDYFITDAEPKIVVC-DPSKRDGIAAIAAKVGATV 125 Query: 263 LRETPGVRHVLVYRKTNNPSVAFHAPRDLDWATEKKKYKTYYPCTPVDSEDPLFLLYTSG 322 P R L + ++D +LYTSG Sbjct: 126 ETLGPDGRGSL--------------------TDAAAGASEAFATIDRGADDLAAILYTSG 165 Query: 323 STGAPKGVQHSTAGYLLGALLTMRYTFDTHQEDVFFTAGDIGWITGHTYVVYGPLLYGCA 382 +TG KG S +L + Y + +DV A I G +V L+ Sbjct: 166 TTGRSKGAMLSHDNLASNSLTLVDY-WRFTPDDVLIHALPIYHTHGL-FVASNVTLFARG 223 Query: 383 TLVFEGTPAYPNYSRYWDIIDEHKVTQFYVAPTALRLLKRAGDSYIENHSLKSLRCLGSV 442 +++F P + + + D++ T PT L ++ + + +R S Sbjct: 224 SMIF--LPKF-DPDKILDLMAR--ATVLMGVPTFYTRLLQSP--RLTKETTGHMRLFISG 276 Query: 443 GEPIAAEVWEWYSEKIGKNEIPIVDTYWQTESGSHLVTPLAGGVTPMKPGSASFPFFGID 502 P+ A+ +S K G +++ Y TE+ + P G PG+ G+ Sbjct: 277 SAPLLADTHREWSAKTGHA---VLERYGMTETNMNTSNPYDGDRV---PGAVGPALPGVS 330 Query: 503 AVVLDPNTGEELNTSHAEGVLAVKAAWPSFARTIWKNHDRYLDTYLNPYPGYYFTGDGAA 562 A V DP TG+EL G++ VK P+ + W+ ++ + + G++ TGD Sbjct: 331 ARVTDPETGKELPRGDI-GMIEVKG--PNVFKGYWRMPEKTKSEFRDD--GFFITGDLGK 385 Query: 563 KDKDGYIWILGRVDDVVNVSGHRLSTAEIEAAIIEDPIVAECAVVGFNDDLTGQAVAAFV 622 D+ GY+ ILGR D+V G + EIE+ I P V E AV+G G+ V A V Sbjct: 386 IDERGYVHILGRGKDLVITGGFNVYPKEIESEIDAMPGVVESAVIGVPHADFGEGVTAVV 445 Query: 623 VLKNKSSWSTATDDELQDIKKHLVFTVRKDIGPFAAPKLIILVDDLPKTRSGKIMRRILR 682 V ++ A ++ + + F PK +I VDDLP+ GK+ + +LR Sbjct: 446 VRDKGATIDEA----------QVLHGLDGQLAKFKMPKKVIFVDDLPRNTMGKVQKNVLR 495 Query: 683 K 683 + Sbjct: 496 E 496 >2V7B-A nrPDB Length = 529 Score = 381 bits (979), Expect = e-106, Method: Composition-based stats. Identities = 139/557 (24%), Positives = 221/557 (39%), Gaps = 47/557 (8%) Query: 127 LNGQLNACYNCVDRHALKTPNKKAIIFEGDEPGQGYSITYKELLEEVCQVAQVLTYSMGV 186 N + + K A I D+ G S TY EL E + A L +GV Sbjct: 19 PPALFNFAAYLFRLNETRAG-KTAYI---DDTG---STTYGELEERARRFASALRT-LGV 70 Query: 187 RKGDTVAVYMPMVPEAIITLLAISRIGAIHSVVFAGFSSNSLRDRINDGDSKVVITTDES 246 + + + M + L G + V + + ++ VI + Sbjct: 71 HPEERILLVMLDTVALPVAFLGALYAGVVPVVANTLLTPADYVYMLTHSHARAVIAS--- 127 Query: 247 NRGGKVIETKRIVDDALRETPGVRHVLVYRKTNNPSVAFHAPRDLDWATEKKKYKTYYPC 306 G V + ++ A E G + ++ + + P +A +D A K Sbjct: 128 --GALVQNVTQALESA--EHDGCQLIVSQPRESEPRLAPLFEELIDAAAPAAKAAAT--- 180 Query: 307 TPVDSEDPLFLLYTSGSTGAPKGVQHSTAGYLLGALLTMRYTFDTHQEDVFFTAGDIGWI 366 +D F LY+SGSTG PKG H+ A A L + + DV F+A + + Sbjct: 181 ---GCDDIAFWLYSSGSTGKPKGTVHTHANLYWTAELYAKPILGIAENDVVFSAAKLFFA 237 Query: 367 TGHTYVVYGPLLYGCATLVFEGTPAYPNYSRYWDIIDEHKVTQFYVAPTALRLLKRAGDS 426 G + PL G ++ P + + EH+ T FY PT + + + Sbjct: 238 YGLGNGLTFPLSVGATAILMAERP---TADAIFARLVEHRPTVFYGVPTLYANMLVSPN- 293 Query: 427 YIENHSLKSLRCLGSVGEPIAAEVWEWYSEKIGKNEIPIVDTYWQTESGSHLVTPLAGGV 486 + + ++R S GE + E+ E ++ G I+D TE ++ AG V Sbjct: 294 -LPARADVAIRICTSAGEALPREIGERFTAHFGCE---ILDGIGSTEMLHIFLSNRAGAV 349 Query: 487 TPMKPGSASFPFFGIDAVVLDPNTGEELNTSHAEGVLAVKAAWPSFARTIWKNHDRYLDT 546 G+ P G + + D G + G L +K PS A W N ++ T Sbjct: 350 E---YGTTGRPVPGYEIELRD-EAGHAVPDGEV-GDLYIKG--PSAAVMYWNNREKSRAT 402 Query: 547 YLNPYPGYYFTGDGAAKDKDGYIWILGRVDDVVNVSGHRLSTAEIEAAIIEDPIVAECAV 606 +L + +GD + +G GR DD++ VSG +S E+E +++ V E AV Sbjct: 403 FLGE---WIRSGDKYCRLPNGCYVYAGRSDDMLKVSGQYVSPVEVEMVLVQHDAVLEAAV 459 Query: 607 VGFNDDLTGQAVAAFVVLKNKSSWSTATDDELQDIKKHLVFTVRKDIGPFAAPKLIILVD 666 VG D AFVVLK + + S +EL+ V+ + P P+ I+ VD Sbjct: 460 VGV-DHGGLVKTRAFVVLKREFAPSEILAEELKAF-------VKDRLAPHKYPRDIVFVD 511 Query: 667 DLPKTRSGKIMRRILRK 683 DLPKT +GKI R LR+ Sbjct: 512 DLPKTATGKIQRFKLRE 528 >3IVR-A nrPDB Length = 509 Score = 380 bits (976), Expect = e-106, Method: Composition-based stats. Identities = 125/554 (22%), Positives = 213/554 (38%), Gaps = 68/554 (12%) Query: 133 ACYNCVDRHALKTPNKKAIIFEGDEPGQGYSITYKELLEEVCQVAQVLTYSMGVRKGDTV 192 + R+A P++ A + + G +T+++ L ++A L GV GD V Sbjct: 7 TLADVYRRNAALFPDRTAFMVD------GVRLTHRDYLARAERLASGLLRD-GVHTGDRV 59 Query: 193 AVYMPMVPEAIITLLAISRIGAIHSVVFAGFSSNSLRDRINDGDSKVVITTDESNRGGKV 252 A+ E I + A++ IGAI V +++ + + DG VV+ Sbjct: 60 AILSQNCSEMIELIGAVALIGAILLPVNYRLNADEIAFVLGDGAPSVVVAG--------- 110 Query: 253 IETKRIVDDALRETPGVRHVLVYRKTNNPSVAFHAPRDLDWATEKKKYKTYYPCTPVDSE 312 + + IV L GV+ + P F D A++ T + + Sbjct: 111 TDYRDIVAGVLPSLGGVKKAYAIGDGSGPFAPFK-----DLASD-----TPFSAPEFGAA 160 Query: 313 DPLFLLYTSGSTGAPKGVQHSTAGYLLGALLTMRYTFDTHQEDVFFTAGDIGWITGHTYV 372 D +++T+ G P+G S G LL A ++ + + DV + +TG + Sbjct: 161 DGFVIIHTAAVGGRPRGALISQ-GNLLIAQSSLVDAWRLTEADVNLGMLPLFHVTGLGLM 219 Query: 373 VYGPLLYGCATLVFEGTPAYPNYSRYWDIIDEHKVTQFY-VAPTALRLLKRAGDSYIENH 431 + G + + + PA I+ HKVT AP +L +A + Sbjct: 220 LTLQQAGGASVIAAKFDPAQAARD-----IEAHKVTVMAEFAPMLGNILDQAAPA----- 269 Query: 432 SLKSLRCLGSVGEPIAAEVWEWYSEKIGKNEIPIVDTYWQTES-GSHLVTPLAGGVTPMK 490 L SLR + + P E +E T+ Q+E+ G P + Sbjct: 270 QLASLRAVTGLDTPETIERFEATCPNA-----TFWATFGQSETSGLSTFAPYRD-----R 319 Query: 491 PGSASFPFFGIDAVVLDPNTGEELNTSHAEGVLAVKAAWPSFARTIWKNHDRYLDTYLNP 550 P SA P F V+D G + ++ P+ + W N + N Sbjct: 320 PKSAGRPLFWRTVAVVDAEDRPLPPGEV--GEIVLRG--PTVFKGYWNNAAATQHAFRN- 374 Query: 551 YPGYYFTGDGAAKDKDGYIWILGRV--DDVVNVSGHRLSTAEIEAAIIEDPIVAECAVVG 608 G++ TGD D DGY++ GR +++ G + AE+E A+ + P +A+ V+G Sbjct: 375 --GWHHTGDMGRFDADGYLFYAGRAPEKELIKTGGENVYPAEVEGALKQHPAIADAVVIG 432 Query: 609 FNDDLTGQAVAAFVVLKNKSSWSTATDDELQDIKKHLVFTVRKDIGPFAAPKLIILVDDL 668 D +A+ A V K S + D L + L I + PK ++ V+ L Sbjct: 433 VPDPQWSEAIKAVCVCKPGESIAA---DALAEFVASL-------IARYKKPKHVVFVEAL 482 Query: 669 PKTRSGKIMRRILR 682 PK G I R ++ Sbjct: 483 PKDAKGAIDRAAVK 496 >1MDF-A nrPDB Length = 539 Score = 379 bits (972), Expect = e-105, Method: Composition-based stats. Identities = 105/557 (18%), Positives = 203/557 (36%), Gaps = 61/557 (10%) Query: 136 NCVDRHALKTPNKKAIIFEGDEPGQGYSITYKELLEEVCQVAQVLTYSMGVRKGDTVAVY 195 + + A K ++ AI +Y+EL ++A +G+++ D V V Sbjct: 29 DLLRDRAAKYGDRIAI------TCGNTHWSYRELDTRADRLAAGFQ-KLGIQQKDRVVVQ 81 Query: 196 MPMVPEAIITLLAISRIGAIHSVVFAGFSSNSLRDRINDGDSKVVITTDESNRGGKVIET 255 +P + E + A+ R+GA+ S+ + ++ I D + + Sbjct: 82 LPNIKEFFEVIFALFRLGALPVFALPSHRSSEITYFCEFAEAAAYIIPDAYSG----FDY 137 Query: 256 KRIVDDALRETPGVRHVLVYRKTNNPSVAFHAPRDLDWATEKKKYKTYYPCTPVDSEDPL 315 + + + P +++++V + F DL + V S D Sbjct: 138 RSLARQVQSKLPTLKNIIVAGEAEE----FLPLEDL--------HTEPVKLPEVKSSDVA 185 Query: 316 FLLYTSGSTGAPKGVQHSTAGYLLGALLTMRYTFDTHQEDVFFTAGDIGWITGHTYVVYG 375 FL + GSTG K + + Y+ ++ + H V+ A + + Sbjct: 186 FLQLSGGSTGLSKLIPRTHDDYIYSLKRSVEVCWLDH-STVYLAALPMAHNYPLSSPGVL 244 Query: 376 PLLYGCATLVFEGTPAYPNYSRYWDIIDEHKVTQFYVAPTALRLLKRAGDSYIENHSLKS 435 +LY +V +P+ + +I+ KVT + P + A S + L S Sbjct: 245 GVLYAGGRVVLSPSPS---PDDAFPLIEREKVTITALVPPLAMVWMDAASSRRD--DLSS 299 Query: 436 LRCLGSVGEPIAAEVWEWYSEKIGKNEIPIVDT------YWQTESGSHLVTPLAGGVTPM 489 L+ L G +AE G + Y + + ++ G PM Sbjct: 300 LQVLQVGGAKFSAEAARRVKAVFGCTLQQVFGMAEGLVNYTRLDDPEEIIVNTQGK--PM 357 Query: 490 KPGSASFPFFGIDAVVLDPNTGEELNTSHAEGVLAVKAAWPSFARTIWKNHDRYLDTYLN 549 P S + D V TG L P R +K + ++ Sbjct: 358 SPYDESRVWDDHDRDVKPGETGHLLTRG------------PYTIRGYYKAEEHNAASFTE 405 Query: 550 PYPGYYFTGDGAAKDKDGYIWILGRVDDVVNVSGHRLSTAEIEAAIIEDPIVAECAVVGF 609 G+Y TGD +DGYI + GR D +N G +++ E+E ++ P V + A+V Sbjct: 406 D--GFYRTGDIVRLTRDGYIVVEGRAKDQINRGGEKVAAEEVENHLLAHPAVHDAAMVSM 463 Query: 610 NDDLTGQAVAAFVVLKNKSSWSTATDDELQDIKKHLVFTVRKDIGPFAAPKLIILVDDLP 669 D G+ F++ ++++ + F + + + P + V+ P Sbjct: 464 PDQFLGERSCVFIIPRDEAPKAAELK----------AFLRERGLAAYKIPDRVEFVESFP 513 Query: 670 KTRSGKIMRRILRKILA 686 +T GK+ ++ LR+ ++ Sbjct: 514 QTGVGKVSKKALREAIS 530 >3RG2-A nrPDB Length = 617 Score = 375 bits (962), Expect = e-104, Method: Composition-based stats. Identities = 118/581 (20%), Positives = 221/581 (38%), Gaps = 65/581 (11%) Query: 136 NCVDRHALKTPNKKAIIFEGDEPGQGYSITYKELLEEVCQVAQVLTYSMGVRKGDTVAVY 195 + + RHA + A+I ++Y+EL + +A L G++ G+T V Sbjct: 31 DILTRHAAS--DSIAVI------DGERQLSYRELNQAADNLACSLR-RQGIKPGETALVQ 81 Query: 196 MPMVPEAIITLLAISRIGAIHSVVFAGFSSNSLRDRINDGDSKVVITTDESNRGGKVIET 255 + V E IT A+ ++G + + L + + ++I +R + Sbjct: 82 LGNVAELYITFFALLKLGVAPVLALFSHQRSELNAYASQIEPALLIA----DRQHALFSG 137 Query: 256 KRIVDDALRETPGVRHVLVYRKTNNPSVAFHAPRDLDWATEKKKYKTYYPCTPVDSEDPL 315 ++ + E +R V + + + + TP +++ Sbjct: 138 DDFLNTFVTEHSSIRVVQLLNDSGEH----------NLQDAINHPAEDFTATPSPADEVA 187 Query: 316 FLLYTSGSTGAPKGVQHSTAGYLLGALLTMRYTFDTHQEDVFFTAGDIGWITGHTYVVYG 375 + + G+TG PK + + Y ++ Q+ + A + Sbjct: 188 YFQLSGGTTGTPKLIPRTHNDYYYSVRRSVEICQ-FTQQTRYLCAIPAAHNYAMSSPGSL 246 Query: 376 PLLYGCATLVFEGTPAYPNYSRYWDIIDEHKVTQFYVAPTALRLLKRA---GDSYIENHS 432 + T+V P+ + + +I++H+V + P A+ L +A G+S + S Sbjct: 247 GVFLAGGTVVLAADPS---ATLCFPLIEKHQVNVTALVPPAVSLWLQALIEGESRAQLAS 303 Query: 433 LKSLRCLG-----SVGEPIAAEVWEWYSEKIGKNEIPIVDTYWQTESGSHLVTPLAGGVT 487 LK L+ G ++ I AE+ + G E + Y + + + + G Sbjct: 304 LKLLQVGGARLSATLAARIPAEIGCQLQQVFGMAEGLV--NYTRLDDSAEKIIHTQG--Y 359 Query: 488 PMKPGSASFPFFGIDAVVLDPNTGEELNTSHAEGVLAVKAAWPSFARTIWKNHDRYLDTY 547 PM P D V + G L G L + P R +K+ + Sbjct: 360 PMCPD---------DEVWVADAEGNPLPQGEV-GRLMTRG--PYTFRGYYKSPQHNASAF 407 Query: 548 LNPYPGYYFTGDGAAKDKDGYIWILGRVDDVVNVSGHRLSTAEIEAAIIEDPIVAECAVV 607 G+Y +GD + D +GYI + GR D +N G +++ EIE ++ P V A+V Sbjct: 408 --DANGFYCSGDLISIDPEGYITVQGREKDQINRGGEKIAAEEIENLLLRHPAVIYAALV 465 Query: 608 GFNDDLTGQAVAAFVVLKNKSSWSTATDDELQDIKKHLVFTVRKDIGPFAAPKLIILVDD 667 D+L G+ A++V+K E + F + I F P + VD Sbjct: 466 SMEDELMGEKSCAYLVVK-----------EPLRAVQVRRFLREQGIAEFKLPDRVECVDS 514 Query: 668 LPKTRSGKIMRRILRKILAGESDQLGDVSTLSNPGIVRHLI 708 LP T GK+ ++ LR+ LA + G S ++ +R +I Sbjct: 515 LPLTAVGKVDKKQLRQWLASRASA-GRASIPASKAALREVI 554 >4GR5-A nrPDB Length = 570 Score = 356 bits (913), Expect = 2e-98, Method: Composition-based stats. Identities = 126/572 (22%), Positives = 222/572 (38%), Gaps = 75/572 (13%) Query: 117 RPSFQNNAWFLNGQLNACYNCVDRHALKTPNKKAIIFEGDEPGQGYSITYKELLEEVCQV 176 RP+ G + + A + P+ A++ E DE +TY L E ++ Sbjct: 62 RPTGPAVERAPAGAC--VHELFEAQAARAPDAVALLHEADE------LTYGALNERANRL 113 Query: 177 AQVLTYSMGVRKGDTVAVYMPMVPEAIITLLAISRIGAIHSVVFAGFSSNSLRDRINDGD 236 A L +GV G V V++ + ++ LLA+ + G ++++ F L + D Sbjct: 114 AHRLV-GLGVAPGTLVGVHLERGFDMVVALLAVLKAGGGYTMLDPQFPVERLALSLEDTG 172 Query: 237 SKVVITTDESNRGGKVIETKRIVDDALRETPGVRHVLVYRKTNNPSVAFHAPRDLDWATE 296 + +++T+ + T + D+A + P Sbjct: 173 APLLVTSRPLSGRLTGTTTLYVEDEAASDAP----------------------------- 203 Query: 297 KKKYKTYYPCTPVDSEDPLFLLYTSGSTGAPKGVQHSTAGYLLGALLTMRYTFDTHQEDV 356 T V ED +++TSGSTG PKGV S L G L Y ++V Sbjct: 204 -----AGNLATGVGPEDVACVMFTSGSTGRPKGVM-SPHRALTGTYLGQDYA-GFGPDEV 256 Query: 357 FFTAGDIGWITGHTYVVYGPLLYGCATLVFEGTPAYPNYSRYWDIIDEHKVTQFYVAPTA 416 F + W ++G LL+G ++ G P+ +++ H VT ++ + Sbjct: 257 FLQCSPVSW-DAFGLELFGALLFGARCVLQSGQ--NPDPLEIGELVARHGVTMLQLSASL 313 Query: 417 LRLLKRAGDSYIENHSLKSLRCLGSVGEP-----IAAEVWEWYSEKIGKNEIPIVDTYWQ 471 L + + +R + GEP +A + + ++G P + Sbjct: 314 FNFLVDEVPE-----AFEGVRYAITGGEPASVPHVAKARRDHPALRLGNGYGPAESMGFT 368 Query: 472 TESGSHLVTPLAGGVTPMKPGSASFPFFGIDAVVLDPNTGEELNTSHAEGVLAVKAAWPS 531 T + L+G P+ P G A VLD + N + E +A Sbjct: 369 THHA-VVAGDLSGTALPI-----GVPLAGKRAYVLDDDLKPAANGALGELYVAGAGLAHG 422 Query: 532 FARTIWKNHDRYL-DTYLNPY-PGYYFTGDGAAKDKDGYIWILGRVDDVVNVSGHRLSTA 589 + +R++ D + P Y TGD A + DG + +GR DD V + G R+ Sbjct: 423 YVSRPALTAERFVADPFAGPGGERMYRTGDLARRRADGVLEYVGRADDQVKIRGFRVEPG 482 Query: 590 EIEAAIIEDPIVAECAVVGFNDDLTGQAVAAFVVLKNKSSWSTATDDELQDIKKHLVFTV 649 E+EA ++ P V + AV+ + L + + A+VV + + A + L V Sbjct: 483 EVEARLVGHPAVRQAAVLAQDSRLGDKQLVAYVVAERADAPPDAAE---------LRRHV 533 Query: 650 RKDIGPFAAPKLIILVDDLPKTRSGKIMRRIL 681 + + + P + VD+LP+T +GK+ RR L Sbjct: 534 AEALPAYMVPVECVPVDELPRTPNGKLDRRAL 565 >5DWV-A nrPDB Length = 573 Score = 355 bits (911), Expect = 3e-98, Method: Composition-based stats. Identities = 111/567 (19%), Positives = 220/567 (38%), Gaps = 51/567 (8%) Query: 126 FLNGQLNACYNCVDRHALKTPNKKAIIFEGDEPGQGYSITYKELLEEVCQVAQVLTYSMG 185 +G + + P A + +ITY E E ++A+ + G Sbjct: 40 LEDGTAGEQLHKAMKRYALVPGTIAFT----DAHIEVNITYAEYFEMSVRLAEAM-KRYG 94 Query: 186 VRKGDTVAVYMPMVPEAIITLLAISRIGAIHSVVFAGFSSNSLRDRINDGDSKVVITTDE 245 + + V + + +L IG + ++ L + +N VV + + Sbjct: 95 LNTNHRIVVCSENSLQFFMPVLGALFIGVAVAPANDIYNERELLNSMNISQPTVVFVSKK 154 Query: 246 SNRGGKVIETKRIVDDALRETPGVRHVLVYRKTNNPSVAFHAPRDLDWATEKKKYKTYYP 305 + + + ++ P ++ +++ + + + + Sbjct: 155 GL---------QKILNVQKKLPIIQKIIIMDSKTDYQGFQSMYTFVTSHLPPGFNEYDFV 205 Query: 306 CTPVDSED-PLFLLYTSGSTGAPKGVQHSTA------GYLLGALLTMRYTFDTHQEDVFF 358 D + ++ +SGSTG PKGV + + + DT V Sbjct: 206 PESFDRDKTIALIMNSSGSTGLPKGVALPHRTACVRFSHARDPIFGNQIIPDTAILSVVP 265 Query: 359 TAGDIGWITGHTYVVYGPLLYGCATLVFEGTPAYPNYSRYWDIIDEHKVTQFYVAPTALR 418 G T Y L+ G ++ + + ++K+ + PT Sbjct: 266 FHHGFGMFTTLGY-----LICGFRVVLMYRF----EEELFLRSLQDYKIQSALLVPTLFS 316 Query: 419 LLKRAGDSYIENHSLKSLRCLGSVGEPIAAEVWEWYSEKIGKNEIPIVDTYWQTESGSHL 478 ++ + I+ + L +L + S G P++ EV E +++ + I Y TE+ S + Sbjct: 317 FFAKS--TLIDKYDLSNLHEIASGGAPLSKEVGEAVAKRF--HLPGIRQGYGLTETTSAI 372 Query: 479 VTPLAGGVTPMKPGSASFPFFGIDAVVLDPNTGEELNTSHAEGVLAVKAAWPSFARTIWK 538 + G KPG+ +A V+D +TG+ L + G L V+ P Sbjct: 373 LITPEGDD---KPGAVGKVVPFFEAKVVDLDTGKTLGVNQ-RGELCVRG--PMIMSGYVN 426 Query: 539 NHDRYLDTYLNPYPGYYFTGDGAAKDKDGYIWILGRVDDVVNVSGHRLSTAEIEAAIIED 598 N + L G+ +GD A D+D + +I+ R+ ++ G++++ AE+E+ +++ Sbjct: 427 NPEATNA--LIDKDGWLHSGDIAYWDEDEHFFIVDRLKSLIKYKGYQVAPAELESILLQH 484 Query: 599 PIVAECAVVGFNDDLTGQAVAAFVVLKNKSSWSTATDDELQDIKKHLVFTVRKDIGPFAA 658 P + + V G DD G+ AA VVL++ T T+ E+ D V T +K G Sbjct: 485 PNIFDAGVAGLPDDDAGELPAAVVVLEHG---KTMTEKEIVDYVASQVTTAKKLRGG--- 538 Query: 659 PKLIILVDDLPKTRSGKIMRRILRKIL 685 ++ VD++PK +GK+ R +R+IL Sbjct: 539 ---VVFVDEVPKGLTGKLDARKIREIL 562 >4M46-A nrPDB Length = 581 Score = 355 bits (909), Expect = 5e-98, Method: Composition-based stats. Identities = 110/566 (19%), Positives = 219/566 (38%), Gaps = 49/566 (8%) Query: 126 FLNGQLNACYNCVDRHALKTPNKKAIIFEGDEPGQGYSITYKELLEEVCQVAQVLTYSMG 185 +G + + + P A + +ITY E E C++A+ + G Sbjct: 51 LEDGTAGEQLHKAMKRYAQVPGTIAFT----DAHAEVNITYSEYFEMACRLAETM-KRYG 105 Query: 186 VRKGDTVAVYMPMVPEAIITLLAISRIGAIHSVVFAGFSSNSLRDRINDGDSKVVITTDE 245 + +AV + + + IG + ++ L + ++ +V + Sbjct: 106 LGLQHHIAVCSENSLQFFMPVCGALFIGVGVAPTNDIYNERELYNSLSISQPTIVFCSKR 165 Query: 246 SNRGGKVIETKRIVDDALRETPGVRHVLVYRKTNNPSVAFHAPRDLDWATEKKKYKTYYP 305 + + + ++ P ++ +++ + ++ + Y Sbjct: 166 AL---------QKILGVQKKLPIIQKIVILDSREDYMGKQSMYSFIESHLPAGFNEYDYI 216 Query: 306 CTPVDSEDP-LFLLYTSGSTGAPKGVQHSTAGYLLGALLTMRYTFDTH--QEDVFFTAGD 362 D E ++ +SGSTG PKGV+ + + F + T Sbjct: 217 PDSFDRETATALIMNSSGSTGLPKGVELTHKNICVRFSHCRDPVFGNQIIPDTAILTVIP 276 Query: 363 IGWITGHTYVVYGPLLY---GCATLVFEGTPAYPNYSRYWDIIDEHKVTQFYVAPTALRL 419 H + ++ L Y G ++ + + ++K+ + PT Sbjct: 277 ----FHHGFGMFTTLGYLTCGFRIVLMYRF----EEELFLRSLQDYKIQSALLVPTLFSF 328 Query: 420 LKRAGDSYIENHSLKSLRCLGSVGEPIAAEVWEWYSEKIGKNEIPIVDTYWQTESGSHLV 479 ++ + ++ + L +L + S G P+A EV E +++ I Y TE+ S ++ Sbjct: 329 FAKS--TLVDKYDLSNLHEIASGGAPLAKEVGEAVAKRF--KLPGIRQGYGLTETTSAII 384 Query: 480 TPLAGGVTPMKPGSASFPFFGIDAVVLDPNTGEELNTSHAEGVLAVKAAWPSFARTIWKN 539 G KPG+ A ++D +TG+ L + G L VK P + N Sbjct: 385 ITPEGDD---KPGACGKVVPFFSAKIVDLDTGKTLGVNQ-RGELCVKG--PMIMKGYVNN 438 Query: 540 HDRYLDTYLNPYPGYYFTGDGAAKDKDGYIWILGRVDDVVNVSGHRLSTAEIEAAIIEDP 599 + + L G+ +GD A DKDG+ +I+ R+ ++ G+++ AE+E+ +++ P Sbjct: 439 PEAT--SALIDKDGWLHSGDIAYYDKDGHFFIVDRLKSLIKYKGYQVPPAELESILLQHP 496 Query: 600 IVAECAVVGFNDDLTGQAVAAFVVLKNKSSWSTATDDELQDIKKHLVFTVRKDIGPFAAP 659 + + V G D G+ AA VVL+ T T+ E+ D V ++ G Sbjct: 497 FIFDAGVAGIPDPDAGELPAAVVVLEEG---KTMTEQEVMDYVAGQVTASKRLRGG---- 549 Query: 660 KLIILVDDLPKTRSGKIMRRILRKIL 685 + VD++PK +GKI R +R+IL Sbjct: 550 --VKFVDEVPKGLTGKIDARKIREIL 573 >3DLP-X nrPDB Length = 504 Score = 348 bits (893), Expect = 4e-96, Method: Composition-based stats. Identities = 131/554 (23%), Positives = 210/554 (37%), Gaps = 59/554 (10%) Query: 131 LNACYNCVDRHALKTPNKKAIIFEGDEPGQGYSITYKELLEEVCQVAQVLTYSMGVRKGD 190 + + R A + P+ A+ P +G +T+ EL V VA L ++ G+R Sbjct: 1 MQTVNEMLRRAATRAPDHCALAV----PARGLRLTHAELRARVEAVAARL-HADGLRPQQ 55 Query: 191 TVAVYMPMVPEAIITLLAISRIGAIHSVVFAGFSSNSLRDRINDGDSKVVITTDESNRGG 250 VAV P + +I +LA+ R+GA+ +++ S L + I G+ Sbjct: 56 RVAVVAPNSADVVIAILALHRLGAVPALLNPRLKSAELAELIKRGEMT-----------A 104 Query: 251 KVIETKRIVDDALRETPGVRHVLVYRKTNNPSVAFHAPRDLDWATEKKKYKTYYPCTPVD 310 VI R V DA +++ + + F D + + Y P Sbjct: 105 AVIAVGRQVADA-----------IFQSGSGARIIFLG----DLVRDGEPYSYGPPIEDPQ 149 Query: 311 --SEDPLFLLYTSGSTGAPKGVQHSTAGYLLGAL-LTMRYTFDTHQEDVFFTAGDIGWIT 367 P F+ YTSG+TG PK L ++ + + +V + + Sbjct: 150 REPAQPAFIFYTSGTTGLPKAAIIPQRAAESRVLFMSTQVGLRHGRHNVVLGLMPLYHVV 209 Query: 368 GHTYVVYGPLLYGCATLVFEGTPAYPNYSRYWDIIDEHKVTQFYVAPTALRLLKRAGDSY 427 G V+ L +V E ++ + +VT + PT L L A Sbjct: 210 GFFAVLVAALALDGTYVVVEEF----RPVDALQLVQQEQVTSLFATPTHLDALAAAAAHA 265 Query: 428 IENHSLKSLRCLGSVGEPIAAEVWEWYSEKIGKNEIPIVDTYWQTESGSHLVTPLAGGVT 487 + L SLR + G + V E + + + V+ Y TE+ + L T Sbjct: 266 GSSLKLDSLRHVTFAGATMPDAVLETVHQHLPGEK---VNIYGTTEAMNSLYMRQPKTGT 322 Query: 488 PMKPGSASFPFFGIDAVVLDPNTGEELNTSHAEGVLAVKAAWPSFARTIWKNHDRYLDTY 547 M PG FF +V +E+ + EG L V A+ S + Sbjct: 323 EMAPG-----FFSEVRIVRIGGGVDEIVANGEEGELIVAASD-SAFVGYLNQPQATAEKL 376 Query: 548 LNPYPGYYFTGDGAAKDKDGYIWILGRVDDVVNVSGHRLSTAEIEAAIIEDPIVAECAVV 607 + G+Y T D A +G + ILGRV D++ G + +EIE + P V E V+ Sbjct: 377 QD---GWYRTSDVAVWTPEGTVRILGRVPDMIISGGENIHPSEIERVLGTAPGVTEVVVI 433 Query: 608 GFNDDLTGQAVAAFVVLKNKSSWSTATDDELQDIKKHLVFTVRKDIGPFAAPKLIILVDD 667 G D GQ+V A VV + + S D F ++ F PK ++D Sbjct: 434 GLADQRWGQSVTACVVPRLGETLSADALD---------TFCRSSELADFKRPKRYFILDQ 484 Query: 668 LPKTRSGKIMRRIL 681 LPK K++RR L Sbjct: 485 LPKNALNKVLRRQL 498 >2D1S-A nrPDB Length = 548 Score = 343 bits (880), Expect = 1e-94, Method: Composition-based stats. Identities = 109/552 (19%), Positives = 212/552 (38%), Gaps = 41/552 (7%) Query: 138 VDRHALKTPNKKAIIFEGDEPGQGYSITYKELLEEVCQVAQVLTYSMGVRKGDTVAVYMP 197 + ++ + AI F G +Y E LE+ C + + L G+ +A+ Sbjct: 29 LRKYMERYAKLGAIAFTNAVT--GVDYSYAEYLEKSCCLGKALQN-YGLVVDGRIALCSE 85 Query: 198 MVPEAIITLLAISRIGAIHSVVFAGFSSNSLRDRINDGDSKVVITTDESNRGGKVIETKR 257 E I ++A IG + ++ L + +V ++ + Sbjct: 86 NCEEFFIPVIAGLFIGVGVAPTNEIYTLRELVHSLGISKPTIVFSSKKGL---------D 136 Query: 258 IVDDALRETPGVRHVLVYRKTNNPSVAFHAPRDLDWATEKKKYKTYYPCTPVDS-EDPLF 316 V + ++ +++ + + T + + VD E Sbjct: 137 KVITVQKTVTTIKTIVILDSKVDYRGYQCLDTFIKRNTPPGFQASSFKTVEVDRKEQVAL 196 Query: 317 LLYTSGSTGAPKGVQHSTAGYLL--GALLTMRYTFDTHQEDVFFTAGDIGWITGHTYVVY 374 ++ +SGSTG PKGVQ + + Y T H + ++ Sbjct: 197 IMNSSGSTGLPKGVQLTHENIVTRFSHARDPIYGNQVSPGTAVLTVVP----FHHGFGMF 252 Query: 375 GPLLYGCATLVFEGTPAYPNYSRYWDIIDEHKVTQFYVAPTALRLLKRAGDSYIENHSLK 434 L Y + + + + ++K T + PT +L ++ + + L Sbjct: 253 TTLGYLICGFRVVMLTKF-DEETFLKTLQDYKCTSVILVPTLFAILNKS--ELLNKYDLS 309 Query: 435 SLRCLGSVGEPIAAEVWEWYSEKIGKNEIPIVDTYWQTESGSHLVTPLAGGVTPMKPGSA 494 +L + S G P++ EV E + + N + Y TE+ S ++ G KPG++ Sbjct: 310 NLVEIASGGAPLSKEVGEAVARRF--NLPGVRQGYGLTETTSAIIITPEGDD---KPGAS 364 Query: 495 SFPFFGIDAVVLDPNTGEELNTSHAEGVLAVKAAWPSFARTIWKNHDRYLDTYLNPYPGY 554 A V+D +T + L + G + VK P + N + + L G+ Sbjct: 365 GKVVPLFKAKVIDLDTKKSLGPNR-RGEVCVKG--PMLMKGYVNNPEATKE--LIDEEGW 419 Query: 555 YFTGDGAAKDKDGYIWILGRVDDVVNVSGHRLSTAEIEAAIIEDPIVAECAVVGFNDDLT 614 TGD D++ + +I+ R+ ++ G+++ AE+E+ +++ P + + V G D + Sbjct: 420 LHTGDIGYYDEEKHFFIVDRLKSLIKYKGYQVPPAELESVLLQHPSIFDAGVAGVPDPVA 479 Query: 615 GQAVAAFVVLKNKSSWSTATDDELQDIKKHLVFTVRKDIGPFAAPKLIILVDDLPKTRSG 674 G+ A VVL+ S T+ E+ D V ++ G + VD++PK +G Sbjct: 480 GELPGAVVVLE---SGKNMTEKEVMDYVASQVSNAKRLRGG------VRFVDEVPKGLTG 530 Query: 675 KIMRRILRKILA 686 KI R +R+IL Sbjct: 531 KIDGRAIREILK 542 >3O84-A nrPDB Length = 544 Score = 342 bits (876), Expect = 3e-94, Method: Composition-based stats. Identities = 123/552 (22%), Positives = 215/552 (38%), Gaps = 69/552 (12%) Query: 146 PNKKAIIFEGDEPGQGYSITYKELLEEVCQVAQVLTYSMGVRKGDTVAVYMPMVPEAIIT 205 P+ AII ++Y EL +A L G+ KGDT V +P V E I Sbjct: 44 PHSLAII------CGERQLSYIELDRLSTNLATRLAEK-GLGKGDTALVQLPNVAEFYIV 96 Query: 206 LLAISRIGAIHSVVFAGFSSNSLRDRINDGDSKVVITTDESNRGGKVIETKRIVDDA--L 263 A+ + G + L I K++I +R +V + +D + Sbjct: 97 FFALLKAGVVVLNALYSHRQYELNAFIKQIQPKLLI----GSRQHEVFSNNQFIDSLHDV 152 Query: 264 RETPGVRHVLVYRKTNNPSVAFHAPRDLDWATEKKKYKTYYPCTPVDSEDPLFLLYTSGS 323 +P + +L ++ T+ LDW + + TP +++ F + GS Sbjct: 153 NLSPEIILMLNHQATD--------FGLLDWIETPAETFVDFSSTP--ADEVAFFQLSGGS 202 Query: 324 TGAPKGVQHSTAGYLLGALLTMRYTFDTHQEDVFFTAGDIGWITGHTYVVYGP----LLY 379 TG PK + + Y + + A H +++ P +L+ Sbjct: 203 TGTPKLIPRTHNDYDYSVRASAEIC-GLNSNTRLLCALP----APHNFMLSSPGALGVLH 257 Query: 380 GCATLVFEGTPAYPNYSRYWDIIDEHKVTQFYVAPTAL-RLLKRAGDSYIENHSLKSLRC 438 +V P + II H+V + P+A+ L++A + SLK L+ Sbjct: 258 AGGCVVMAPNP---EPLNCFSIIQRHQVNMASLVPSAVIMWLEKAAQYKDQIQSLKLLQV 314 Query: 439 LG-SVGEPIAAEVWEWYSEK----IGKNEIPIVDTYWQTESGSHLVTPLAGGVTPMKPGS 493 G S E +A +V E + K G E +V+ +S + T T +P S Sbjct: 315 GGASFPESLARQVPEVLNCKLQQVFGMAE-GLVNYTRLDDSDEQIFT------TQGRPIS 367 Query: 494 ASFPFFGIDAVVLDPNTGEELNTSHAEGVLAVKAAWPSFARTIWKNHDRYLDTYLNPYPG 553 + +D + GE G+LA + P +++ + + Sbjct: 368 SDDEIKIVDEQYREVPEGEI-------GMLATRG--PYTFCGYYQSPEHNSQVF--DEDN 416 Query: 554 YYFTGDGAAKDKDGYIWILGRVDDVVNVSGHRLSTAEIEAAIIEDPIVAECAVVGFNDDL 613 YY++GD + DG + ++GR+ D +N G ++++ EIE I+ P V A+V D+ Sbjct: 417 YYYSGDLVQRTPDGNLRVVGRIKDQINRGGEKIASEEIEKLILLHPEVMHAALVAIVDEQ 476 Query: 614 TGQAVAAFVVLKNKSSWSTATDDELQDIKKHLVFTVRKDIGPFAAPKLIILVDDLPKTRS 673 G+ AF+V +N + L ++ I + P I L++ LP T Sbjct: 477 FGEKSCAFIVSRNPELKAVVLRRHLMEL----------GIAQYKLPDQIKLIESLPLTAV 526 Query: 674 GKIMRRILRKIL 685 GK+ ++ LR IL Sbjct: 527 GKVDKKQLRSIL 538 >3IPL-A nrPDB Length = 501 Score = 336 bits (862), Expect = 2e-92, Method: Composition-based stats. Identities = 110/552 (19%), Positives = 215/552 (38%), Gaps = 69/552 (12%) Query: 137 CVDRHALKTPNKKAIIFEGDEPGQGYSITYKELLEEVCQVAQVLTYSMGVRKGDTVAVYM 196 + + A + + AI +G E S TY+ L E A +L + + V +Y+ Sbjct: 6 WLYKQAQQNGHHIAIT-DGQE-----SYTYQNLYCE----ASLLAKRLKAYQQSRVGLYI 55 Query: 197 PMVPEAIITLLAISRIGAIHSVVFAGFSSNSLRDRINDGDSKVVITTDESNRGGKVIETK 256 ++II + A +++ + N + +++ D +++ T G I + Sbjct: 56 DNSIQSIILIHACWLANIEIAMINTRLTPNEMTNQMRSIDVQLIFCTLPLELRGFQIVSL 115 Query: 257 RIVDDALRETPGVRHV-----LVYRKTNNPSVAFHAPRDLDWATEKKKYKTYYPCTPVDS 311 ++ A R+ + + Y +N V +P ++ T + Sbjct: 116 DDIEFAGRDITTNGLLDNTMGIQYDTSNETVVPKESPSNI-------------LNTSFNL 162 Query: 312 EDPLFLLYTSGSTGAPKGVQHSTAGYLLGALLTMRYTFDTHQEDVFFTAGDIGWITGHTY 371 +D +++TSG+TG K V + + A+ + + ++ + + I I+G + Sbjct: 163 DDIASIMFTSGTTGPQKAVPQTFRNHYASAI-GCKESLGFDRDTNWLSVLPIYHISGLS- 220 Query: 372 VVYGPLLYGCATLVFEGTPAYPNYSRYWDIIDEHKVTQFYVAPTALRLLKRAGDSYIENH 431 V+ ++ G + + N + +I ++T + P L L + G E + Sbjct: 221 VLLRAVIEGFTVRIVDKF----NAEQILTMIKNERITHISLVPQTLNWLMQQGLH--EPY 274 Query: 432 SLKSLRCLGSVGEPIAAEVWEWYSEKIGKNEIPIVDTYWQTESGSHLVTPLAGGVTPMKP 491 +L+ + G+ E Y+ +PI +++ TE+ S +T + +P Sbjct: 275 NLQKILLGGAKLSATMIETALQYN-------LPIYNSFGMTETCSQFLTATP-EMLHARP 326 Query: 492 GSASFPFFGIDAVVLDPNTGEELNTSHAEGVLAVKAAWPSFARTIWKNHDRYLDTYLNPY 551 + P +D + +PN G L +K A + T+ N Sbjct: 327 DTVGMPSANVDVKIKNPNK-------EGHGELMIKGA--NVMNGY-LYPTDLTGTFEN-- 374 Query: 552 PGYYFTGDGAAKDKDGYIWILGRVDDVVNVSGHRLSTAEIEAAIIEDPIVAECAVVGFND 611 GY+ TGD A D +GY+ I R D++ G + +IE + P +++ VG D Sbjct: 375 -GYFNTGDIAEIDHEGYVMIYDRRKDLIISGGENIYPYQIETVAKQFPGISDAVCVGHPD 433 Query: 612 DLTGQAVAAFVVLKNKSSWSTATDDELQDIKKHLVFTVRKDIGPFAAPKLIILVDDLPKT 671 D GQ + V ++ S K L+ + K + + PK VD LP T Sbjct: 434 DTWGQVPKLYFVSESDIS------------KAQLIAYLSKHLAKYKVPKHFEKVDTLPYT 481 Query: 672 RSGKIMRRILRK 683 +GK+ R L + Sbjct: 482 STGKLQRNKLYR 493 >1V25-A nrPDB Length = 541 Score = 297 bits (761), Expect = 7e-81, Method: Composition-based stats. Identities = 108/570 (18%), Positives = 203/570 (35%), Gaps = 58/570 (10%) Query: 126 FLNGQLNACYNC---VDRHALKTPNKKAIIFEGDEPGQGYSITYKELLEEVCQVAQVLTY 182 F + ++ N ++R A K+ + G+ + TY E+ + ++ L Sbjct: 9 FPSTMMDEELNLWDFLERAAALFGRKE--VVSRLHTGEVHRTTYAEVYQRARRLMGGLR- 65 Query: 183 SMGVRKGDTVAVYMPMVPEAIITLLAISRIGAIHSVVFAGFSSNSLRDRINDGDSKVVIT 242 ++GV GD VA + A+ +GA+ S + +N + KV++ Sbjct: 66 ALGVGVGDRVATLGFNHFRHLEAYFAVPGMGAVLHTANPRLSPKEIAYILNHAEDKVLLF 125 Query: 243 TDESNRGGKVIETKRIVDDALRETPGVRHVLVYRKTNNPSVAFHAPRDLDWATEKKKYKT 302 +V+ E V+H +V + P L + + Sbjct: 126 DPNLLP---------LVEAIRGELKTVQHFVVMDE-KAPEGYLAYEEALGEEADPVRVPE 175 Query: 303 YYPCTPVDSEDPLFLLYTSGSTGAPKGVQHSTAGYLLGALL-TMRYTFDTHQEDVFFTAG 361 C + YT+G+TG PKGV +S +L +L ++ ++DV Sbjct: 176 RAACG---------MAYTTGTTGLPKGVVYSHRALVLHSLAASLVDGTALSEKDVVLPVV 226 Query: 362 DIGWITGHTYVVYGPLLYGCATLVFEGTPAYPNYSRYWDIIDEHKVTQFYVAPTALRLLK 421 + + + Y L G ++ + + ++ D VT PT L Sbjct: 227 PMFHVNA-WCLPYAATLVGAKQVLPGP---RLDPASLVELFDGEGVTFTAGVPTV--WLA 280 Query: 422 RAGDSYIENHSLKSLRCLGSVGEPIAAEVWEWYSEKIGKNEIPIVDTYWQTESGSHLVTP 481 A H LK+LR L G + + + + + Y TE+ +V Sbjct: 281 LADYLESTGHRLKTLRRLVVGGSAAPRSLI----ARFERMGVEVRQGYGLTETSPVVVQN 336 Query: 482 --------LAGGVTPMKPGSASFPFFGIDAVVLDPNTGEELNTSHAEGVLAVKAAWPSFA 533 L+ P + V D A G + +K W Sbjct: 337 FVKSHLESLSEEEKLTLKAKTGLPIPLVRLRVADEEGRPVPKDGKALGEVQLKGPW--IT 394 Query: 534 RTIWKNHDRYLDTYLNPYPGYYFTGDGAAKDKDGYIWILGRVDDVVNVSGHRLSTAEIEA 593 + N + G++ TGD A D++GY+ I R+ D++ G +S+ ++E Sbjct: 395 GGYYGNEEATRSAL--TPDGFFRTGDIAVWDEEGYVEIKDRLKDLIKSGGEWISSVDLEN 452 Query: 594 AIIEDPIVAECAVVGFNDDLTGQAVAAFVVLKNKSSWSTATDDELQDIKKHLVFTVRKDI 653 A++ P V E AVV + A VV + + ++ L ++ Sbjct: 453 ALMGHPKVKEAAVVAIPHPKWQERPLAVVVPRGEKPTPEELNEHL----------LKAGF 502 Query: 654 GPFAAPKLIILVDDLPKTRSGKIMRRILRK 683 + P + +++P+T +GK ++R LR+ Sbjct: 503 AKWQLPDAYVFAEEIPRTSAGKFLKRALRE 532 >5ES8-A nrPDB Length = 776 Score = 270 bits (690), Expect = 1e-72, Method: Composition-based stats. Identities = 98/563 (17%), Positives = 196/563 (34%), Gaps = 81/563 (14%) Query: 135 YNCVDRHALKTPNKKAIIFEGDEPGQGYSITYKELLEEVCQVAQVLTYSMGVRKGDTVAV 194 + ++ TP+ A++ +G S+TYK+L E Q+A L GV+ D VA+ Sbjct: 206 HQLFEQQVEMTPDHVAVV------DRGQSLTYKQLNERANQLAHHLRGK-GVKPDDQVAI 258 Query: 195 YMPMVPEAIITLLAISRIGAIHSVVFAGFSSNSLRDRINDGDSKVVITTDESNRGGKVIE 254 + + I+++LA+ + G + + + + + D + +++T Sbjct: 259 MLDKSLDMIVSILAVMKAGGAYVPIDPDYPGERIAYMLADSSAAILLTNA---------- 308 Query: 255 TKRIVDDALRETPGVRHVLVYRKTNNPSVAFHAPRDLDWATEKKKYKTYYPCTPVDSEDP 314 ++ + N + D D +E + +D Sbjct: 309 -------------------LHEEKANGACDIIDVHDPDSYSENTNNLPHVN----RPDDL 345 Query: 315 LFLLYTSGSTGAPKGVQHSTAGYLLGALLTMRYTFDTHQEDVFFTAGDIGWITGHTYVVY 374 ++++YTSGSTG KGV L+ R F D + G ++ Sbjct: 346 VYVMYTSGSTGLAKGVMIEHHN-LVNFCEWYRPYFGVTPADKALVYSSFSF-DGSALDIF 403 Query: 375 GPLLYGCATLVFEGTPAYPNYSRYWDIIDEHKVTQFYVAPTALRLLKRAGDSYIENHSLK 434 LL G A + Y + D ++ +T Y+ A + + + Sbjct: 404 THLLAGAALHIVPSERKY-DLDALNDYCNQEGITISYLPTGAAEQFMQMDN--------Q 454 Query: 435 SLRCLGSVGEPIAAEVWEWYSEKIGKNEIPIVDTYWQTESGSHLVTPLAGGVTPMKPGSA 494 S R + + G + + + + Y TE ++ + P Sbjct: 455 SFRVVITGG--------DVLKKIERNGTYKLYNGYGPTECT--IMVTMFEVDKPYANIPI 504 Query: 495 SFPFFGIDAVVLDPNTGEELNTSHAEGVLAVKAAWPSFARTIWKNHDRYLDTYL---NPY 551 P ++LD + E + + R + + ++ Sbjct: 505 GKPIDRTRILILDEALALQPIGVAGELFIVGEG----LGRGYLNRPELTAEKFIVHPQTG 560 Query: 552 PGYYFTGDGAAKDKDGYIWILGRVDDVVNVSGHRLSTAEIEAAIIEDPIVAECAVVGFND 611 Y TGD A DG I LGR+D++V + G+R+ EIE ++ P++ V+ Sbjct: 561 ERMYRTGDRARFLPDGNIEFLGRLDNLVKIRGYRIEPGEIEPFLMNHPLIELTTVLAKEQ 620 Query: 612 DLTGQAVAAFVVLKNKSSWSTATDDELQDIKKHLVFTVRKDIGPFAAPKLIILVDDLPKT 671 + + + V + + + D+ + P + + P T Sbjct: 621 ADGRKYLVGYYVAPEEIPHGELRE------------WLGNDLPDYMIPTYFVHMKAFPLT 668 Query: 672 RSGKIMRRILRKILAGESDQLGD 694 +GK+ RR L + A +++ LG+ Sbjct: 669 ANGKVDRRALPDVQA-DAELLGE 690 >4LGC-A nrPDB Length = 539 Score = 267 bits (682), Expect = 1e-71, Method: Composition-based stats. Identities = 102/567 (17%), Positives = 186/567 (32%), Gaps = 80/567 (14%) Query: 123 NAWFLNGQLNACYNCVDRHALKTPNKKAIIFEGDEPGQGYSITYKELLEEVCQVAQVLTY 182 N QL C P+ A+I E IT+ +L Q+A L Sbjct: 47 NFVTPGKQLEYVSEC-------KPDSTAVICLDKE-QNCSVITWHQLHVYSSQLAWYLIE 98 Query: 183 SMGVRKGDTVAVYMPMVPEAIITLLAISRIGAIHSVVFAGFSSNSLRDRINDGDSKVVIT 242 + + G V P E II + AI + GA + + + + +R+ Sbjct: 99 NE-IGPGSIVLTMFPNSIEHIIAVFAIWKAGACYMPMSYKAAESEIREAC---------- 147 Query: 243 TDESNRGGKVIETKRIVDDALRETPGVRHVLVYRKTNNPSVAFHAPRDLDWATEKKKYKT 302 D + + P + F D + + + K Sbjct: 148 -----------------DTIHPNA-------AFAECKIPGLKFCLSADEIYEAMEGRSKE 183 Query: 303 YYPCTPVDSEDPLFLLYTSGSTGAPKGVQHS-TAGYLLGALLTMRYTFDTHQEDVFFTAG 361 + + + G++G K ++ + G + + E G Sbjct: 184 MPSDRLANPN---MISLSGGTSGKMKFIRQNLPCGLDDETIRSWSLMSGMGFEQRQLLVG 240 Query: 362 DIGWITGHTYVVYGPLLYGCATLVFEGTPAYPNYSRYWDIIDEHKVTQFYVAPTALRLLK 421 + H+ + L G ++ ++I ++K+ + PT + L Sbjct: 241 PLFHGAPHS-AAFNGLFMGNTLVL----TRNLCPGNILNMIKKYKIEFIQMVPTLMNRLA 295 Query: 422 R-AGDSYIENHSLKSLRCLGSVGEPIAAEVWEWYSEKIGKNEIPIVDTYWQTESGSHLVT 480 + G + SLK+L G V P ++W + +G + I + Y TE +T Sbjct: 296 KLEGVGKEDFASLKALCHTGGVCSPWLKQIW---IDLLGPEK--IYEMYSMTECIG--LT 348 Query: 481 PLAGGVTPMKPGSASFPFFGIDAVVLDPNTGEELNTSHAEGVLAVKAAWPSFARTIWKNH 540 + G PGS P + D N E G + + A Sbjct: 349 CIRGDEWVKHPGSIGRPVGDSKVSIRDENGKEVAPFEI--GEIYMTAPASYLVTEYINWE 406 Query: 541 DRYLDTYLNPYPGYYFTGDGAAKDKDGYIWILGRVDDVVNVSGHRLSTAEIEAAIIEDPI 600 + G+ GD D+ GY++ R D++ G + E+E A++ Sbjct: 407 PLEVKE-----GGFRSVGDIGYVDEQGYLYFSDRRSDMLVSGGENVFATEVETALLRYKD 461 Query: 601 VAECAVVGFNDDLTGQAVAAFVVLKNKSSWSTATDDELQDIKKHLVFTVRKDIGPFAAPK 660 + + VVG D+ G+ + A + + +EL+ +RK + P+ PK Sbjct: 462 ILDAVVVGIPDEDLGRRLHAVI-----ETGKEIPAEELKTF-------LRKYLTPYKIPK 509 Query: 661 LIILVDDLPKTRSGKIMR-RILRKILA 686 V + + +GK R RIL +A Sbjct: 510 TFEFVRSIRRGDNGKADRKRILEDCIA 536 >5ES6-A nrPDB Length = 685 Score = 266 bits (680), Expect = 2e-71, Method: Composition-based stats. Identities = 96/555 (17%), Positives = 190/555 (34%), Gaps = 80/555 (14%) Query: 135 YNCVDRHALKTPNKKAIIFEGDEPGQGYSITYKELLEEVCQVAQVLTYSMGVRKGDTVAV 194 + ++ TP+ A++ +G S+TYK+L E Q+A L GV+ D VA+ Sbjct: 206 HQLFEQQVEMTPDHVAVV------DRGQSLTYKQLNERANQLAHHLRGK-GVKPDDQVAI 258 Query: 195 YMPMVPEAIITLLAISRIGAIHSVVFAGFSSNSLRDRINDGDSKVVITTDESNRGGKVIE 254 + + I+++LA+ + G + + + + + D + +++T Sbjct: 259 MLDKSLDMIVSILAVMKAGGAYVPIDPDYPGERIAYMLADSSAAILLTNA---------- 308 Query: 255 TKRIVDDALRETPGVRHVLVYRKTNNPSVAFHAPRDLDWATEKKKYKTYYPCTPVDSEDP 314 ++ + N + D D +E + +D Sbjct: 309 -------------------LHEEKANGACDIIDVHDPDSYSENTNNLPHVN----RPDDL 345 Query: 315 LFLLYTSGSTGAPKGVQHSTAGYLLGALLTMRYTFDTHQEDVFFTAGDIGWITGHTYVVY 374 ++++YTSGSTG KGV L+ R F D + G ++ Sbjct: 346 VYVMYTSGSTGLAKGVMIEHHN-LVNFCEWYRPYFGVTPADKALVYSSFSF-DGSALDIF 403 Query: 375 GPLLYGCATLVFEGTPAYPNYSRYWDIIDEHKVTQFYVAPTALRLLKRAGDSYIENHSLK 434 LL G A + Y + D ++ +T Y+ A + + + Sbjct: 404 THLLAGAALHIVPSERKY-DLDALNDYCNQEGITISYLPTGAAEQFMQMDN--------Q 454 Query: 435 SLRCLGSVGEPIAAEVWEWYSEKIGKNEIPIVDTYWQTESGSHLVTPLAGGVTPMKPGSA 494 S R + + G + + + + Y TE ++ + P Sbjct: 455 SFRVVITGG--------DVLKKIERNGTYKLYNGYGPTECT--IMVTMFEVDKPYANIPI 504 Query: 495 SFPFFGIDAVVLDPNTGEELNTSHAEGVLAVKAAWPSFARTIWKNHDRYLDTYL---NPY 551 P ++LD + E + + R + + ++ Sbjct: 505 GKPIDRTRILILDEALALQPIGVAGELFIVGEG----LGRGYLNRPELTAEKFIVHPQTG 560 Query: 552 PGYYFTGDGAAKDKDGYIWILGRVDDVVNVSGHRLSTAEIEAAIIEDPIVAECAVVGFND 611 Y TGD A DG I LGR+D++V + G+R+ EIE ++ P++ V+ Sbjct: 561 ERMYRTGDRARFLPDGNIEFLGRLDNLVKIRGYRIEPGEIEPFLMNHPLIELTTVLAKEQ 620 Query: 612 DLTGQAVAAFVVLKNKSSWSTATDDELQDIKKHLVFTVRKDIGPFAAPKLIILVDDLPKT 671 + + + V + + + D+ + P + + P T Sbjct: 621 ADGRKYLVGYYVAPEEIPHGELRE------------WLGNDLPDYMIPTYFVHMKAFPLT 668 Query: 672 RSGKIMRRILRKILA 686 +GK+ RR L + A Sbjct: 669 ANGKVDRRALPDVQA 683 >5WMM-A nrPDB Length = 926 Score = 266 bits (678), Expect = 3e-71, Method: Composition-based stats. Identities = 110/518 (21%), Positives = 181/518 (34%), Gaps = 72/518 (13%) Query: 131 LNACYNCVDRHALKTPNKKAIIFEGDEPGQGYSITYKELLEEVCQVAQVLTYSMGVRKGD 190 + + P A++ E S TY EL ++A L ++ GV + Sbjct: 53 VGTIPERFAAVVAEQPEAVALVAADGE----ESWTYGELDRWANRIAHHL-HARGVGRQH 107 Query: 191 TVAVYMPMVPEAIITLLAISRIGAIHSVVFAGFSSNSLRDRINDGDSKVVITTDESNRGG 250 VA+ M P + +L + GA + V + + + D D +VI Sbjct: 108 RVALVMERSPLLVAAVLGTLKAGACYVPVEPTWPRARIDLVLADLDPALVI--------- 158 Query: 251 KVIETKRIVDDALRETPGVRHVLVYRKTNNPSVAFHAPRDLDWATEKKKYKTYYPCTPVD 310 D+ L E V Sbjct: 159 ---------DERLAE----------------------------EDLTGYPTRPLDTADVG 181 Query: 311 SEDPLFLLYTSGSTGAPKGVQHSTAGYLLGALLTMRYTFDTHQEDVFFTAGDIGWITGHT 370 E +L+YTSGSTG PKGV+ S L AL D + V A T Sbjct: 182 GEHLAYLMYTSGSTGTPKGVEVSHRNVLSLALDPC--WADADHQRVLVHAPPTF--DAST 237 Query: 371 YVVYGPLLYGCATLVFEGTPAYPNYSRYWDIIDEHKVTQFYVAPTALRLLKRAGDSYIEN 430 Y ++ PLL+G A +V P + +R +I E VT ++ L+ + Sbjct: 238 YEMWVPLLHGGAAVVAP--PGKLDAARLATLIAERGVTALWLPAGLFDLITQH--HPKSF 293 Query: 431 HSLKSLRCLGSVGEPIAAEVWEWYSEKIGKNEIPIVDTYWQTESGS----HLVTPLAGGV 486 ++ + G V P A + +V+ Y TE+ + + ++ A Sbjct: 294 VQVREVWAGGDVLSPAAVRRLVR-----DDGTLTVVNGYGPTETTTFAARYRMSAPARCK 348 Query: 487 TPMKPGSASFPFFGIDAVVLDPNTGEELNTSHAEGVLAVKAAWPSFARTIWKNHDRYL-D 545 P+ G P G LD + E + +A +R++ D Sbjct: 349 DPLPIGE---PMAGSRLYALDDRLRQVPQGVIGELYVGGDGVARGYANHPPLTSERFVAD 405 Query: 546 TYLNPYPGYYFTGDGAAKDKDGYIWILGRVDDVVNVSGHRLSTAEIEAAIIEDPIVAECA 605 + P Y TGD + DG + LGRVD+ V + G R+ EI AA+ + VA+ Sbjct: 406 PFGRPGERMYRTGDLVRWNHDGQLEFLGRVDEQVKIRGFRVEPGEIRAALRKRDGVAQAV 465 Query: 606 VVGFNDDLTGQAVAAFVVLKNKSSWSTATDDELQDIKK 643 VV D L + + A+VV + + + + ++ + Sbjct: 466 VVPRTDRLGERRLVAYVVPEVPAGADEDSTEHVEKWRA 503 Score = 39.5 bits (90), Expect = 0.005, Method: Composition-based stats. Identities = 15/87 (17%), Positives = 33/87 (37%), Gaps = 1/87 (1%) Query: 599 PIVAECAVVGFNDDLTGQAVAAFVVLKNKSSWS-TATDDELQDIKKHLVFTVRKDIGPFA 657 P E ++ + V V + + + A + + L + ++ Sbjct: 839 PGWFEAVIIPVDSGHCRDGVYRPVGPRPRQLVNLPAAARRVSRLPSWLREELAAELPEHL 898 Query: 658 APKLIILVDDLPKTRSGKIMRRILRKI 684 P I++++ LP T +GKI L ++ Sbjct: 899 VPGDIVVMERLPLTTNGKIDHSRLPEV 925 >4GR4-A nrPDB Length = 469 Score = 261 bits (667), Expect = 6e-70, Method: Composition-based stats. Identities = 97/467 (20%), Positives = 171/467 (36%), Gaps = 66/467 (14%) Query: 117 RPSFQNNAWFLNGQLNACYNCVDRHALKTPNKKAIIFEGDEPGQGYSITYKELLEEVCQV 176 RP+ G + + A + P+ A++ E DE +TY L E ++ Sbjct: 62 RPTGPAVERAPAGAC--VHELFEAQAARAPDAVALLHEADE------LTYGALNERANRL 113 Query: 177 AQVLTYSMGVRKGDTVAVYMPMVPEAIITLLAISRIGAIHSVVFAGFSSNSLRDRINDGD 236 A L +GV G V V++ + ++ LLA+ + G ++++ F L + D Sbjct: 114 AHRLV-GLGVAPGTLVGVHLERGFDMVVALLAVLKAGGGYTMLDPQFPVERLALSLEDTG 172 Query: 237 SKVVITTDESNRGGKVIETKRIVDDALRETPGVRHVLVYRKTNNPSVAFHAPRDLDWATE 296 + +++T+ + T + D+A + P Sbjct: 173 APLLVTSRPLSGRLTGTTTLYVEDEAASDAP----------------------------- 203 Query: 297 KKKYKTYYPCTPVDSEDPLFLLYTSGSTGAPKGVQHSTAGYLLGALLTMRYTFDTHQEDV 356 T V ED +++TSGSTG PKGV S L G L Y ++V Sbjct: 204 -----AGNLATGVGPEDVACVMFTSGSTGRPKGVM-SPHRALTGTYLGQDYA-GFGPDEV 256 Query: 357 FFTAGDIGWITGHTYVVYGPLLYGCATLVFEGTPAYPNYSRYWDIIDEHKVTQFYVAPTA 416 F + W ++G LL+G ++ G P+ +++ H VT ++ + Sbjct: 257 FLQCSPVSW-DAFGLELFGALLFGARCVLQSGQ--NPDPLEIGELVARHGVTMLQLSASL 313 Query: 417 LRLLKRAGDSYIENHSLKSLRCLGSVGEP-----IAAEVWEWYSEKIGKNEIPIVDTYWQ 471 L + + +R + GEP +A + + ++G P + Sbjct: 314 FNFLVDEVPE-----AFEGVRYAITGGEPASVPHVAKARRDHPALRLGNGYGPAESMGFT 368 Query: 472 TESGSHLVTPLAGGVTPMKPGSASFPFFGIDAVVLDPNTGEELNTSHAEGVLAVKAAWPS 531 T + L+G P+ P G A VLD + N + E +A Sbjct: 369 THHA-VVAGDLSGTALPI-----GVPLAGKRAYVLDDDLKPAANGALGELYVAGAGLAHG 422 Query: 532 FARTIWKNHDRYL-DTYLNP-YPGYYFTGDGAAKDKDGYIWILGRVD 576 + +R++ D + P Y TGD A + DG + +GR D Sbjct: 423 YVSRPALTAERFVADPFAGPGGERMYRTGDLARRRADGVLEYVGRAD 469 >3LNV-A nrPDB Length = 590 Score = 252 bits (644), Expect = 3e-67, Method: Composition-based stats. Identities = 111/595 (18%), Positives = 197/595 (33%), Gaps = 77/595 (12%) Query: 130 QLNACYNCVDRHALKTPNKKAIIFEGDEPGQGYSITYKELLEEVCQVAQVLTYSMGVRKG 189 Q + + V AL +PNKK+ F E + ++TY++L + +A L + G + G Sbjct: 9 QCQSLVDVVRLRALHSPNKKSCTFLNKELEE--TMTYEQLDQHAKAIAATLQ-AEGAKPG 65 Query: 190 DTVAVYMPMVPEAIITLLAISRIGAIHSVVFAGFSSNSLRDRINDGDSKVVITTDESNRG 249 D V + I L G I + ++++ D ++V + Sbjct: 66 DRVLLLFAPGLPLIQAFLGCLYAGCIAVPI-----YPPAQEKLLDKAQRIVTNSKPVIVL 120 Query: 250 GKVIETKRIVDDALRETPGVRHVLVYRKTNNPSVAFHAPRDLDWATEKKKYKTYYPCTPV 309 K+ D L P + P++A + E + ++ P T + Sbjct: 121 MIADHIKKFTADELNTNPKFLKI--------PAIALES-------IELNRSSSWQP-TSI 164 Query: 310 DSEDPLFLLYTSGSTGAPKGVQHSTAGYLLGALLTMRYTFDTHQEDVFFTAGDIGWITGH 369 S D FL YTSGST PKGV S LL L + +F + E + F+ G Sbjct: 165 KSNDIAFLQYTSGSTMHPKGVMVSHHN-LLDNLNKIFTSFHMNDETIIFSWLPPHHDMGL 223 Query: 370 TYVVYGPLLYGCATLVFEGTPAYPNYSRYWDIIDEHKVTQFYVAPTALRLLKRA-GDSYI 428 + P+ G ++ N + I ++K T A + + Sbjct: 224 IGCILTPIYGGIQAIMMSPFSFLQNPLSWLKHITKYKATISGSPNFAYDYCVKRIREEKK 283 Query: 429 ENHSLKSLRCLGSVGEPIAAEVWEWYSE---KIGKNEIPIVDTYWQTESGSHLVTPLAGG 485 E L S + EP+ E E + + + G + Y E+ + G Sbjct: 284 EGLDLSSWVTAFNGAEPVREETMEHFYQAFKEFGFRKEAFYPCYGLAEATLLVTGGTPGS 343 Query: 486 VTPM-------------------KPGSASFPFFG---IDAVVLDPNTGEELNTSHAEGVL 523 PGS G + ++DP+T + G + Sbjct: 344 SYKTLTLAKEQFQDHRVHFADDNSPGSYKLVSSGNPIQEVKIIDPDTLIPCDFDQV-GEI 402 Query: 524 AVKAAWPSFARTIWKNHDRYLDTYLNPYPG------YYFTGDGAAKDKDGYIWILGRVDD 577 V++ S A+ W + + Y TGD + +++ GR+ D Sbjct: 403 WVQSN--SVAKGYWNQPEETRHAFAGKIKDDERSAIYLRTGDLGFL-HENELYVTGRIKD 459 Query: 578 VVNVSGHRLSTAEIEAAIIEDP-----IVAECAVVGFNDDLTGQAVAAFVVLKNKSSWST 632 ++ + G +IE +++ P V+ + + Sbjct: 460 LIIIYGKNHYPQDIEFSLMHSPLHHVLGKCAAFVIQEEHEYKLTVMCEVKNRFMDDVAQD 519 Query: 633 ATDDELQDIK--KHLVFTVRKDIGPFAAPKLIILVDDLPKTRSGKIMRRILRKIL 685 +E+ ++ H + + P +P T SGKI R RK L Sbjct: 520 NLFNEIFELVYENHQLEVHTIVLIPLK---------AMPHTTSGKIRRNFCRKHL 565 >3L8C-A nrPDB Length = 521 Score = 247 bits (630), Expect = 1e-65, Method: Composition-based stats. Identities = 94/529 (17%), Positives = 189/529 (35%), Gaps = 57/529 (10%) Query: 161 GYSITYKELLEEVCQVAQVLTYSMGVRKGDTVAVYMPMVPEAIITLLAISRIGAIHSVVF 220 G TY +L + +A S+ + V V+ + + T +A+++ G + V Sbjct: 27 GERRTYGQLKRDSDSIAA-FIDSLALLAKSPVLVFGAQTYDMLATFVALTKSGHAYIPVD 85 Query: 221 AGFSSNSLRDRINDGDSKVVITTDESNRGGKVIETKRIVDDALRETPGVRHVLVYRKTNN 280 + + I ++I +E E + + Sbjct: 86 VHSAPERILAIIEIAKPSLIIAIEEFP--------------LTIEGISLVSLSEIESAKL 131 Query: 281 PSVAFHAPRDLDWATEKKKYKTYYPCTPVDSEDPLFLLYTSGSTGAPKGVQHSTAGYLLG 340 + + V +D ++++TSG+TG PKGVQ S L Sbjct: 132 AEMPYER------------------THSVKGDDNYYIIFTSGTTGQPKGVQISHDNLLSF 173 Query: 341 ALLTM-RYTFDTHQEDVFFTAGDIGWITGHTYVVYGPLLYGCATLVFEGTPAYPNYSRYW 399 + FD ++ + Y + P L TL ++ + + Sbjct: 174 TNWMIEDAAFDVPKQPQMLAQPPYSFDLSVMY--WAPTLALGGTLFALPKELVADFKQLF 231 Query: 400 DIIDEHKVTQFYVAPTALRLLKRAGDSYIENHSLKSLRCLGSVGEPIAAEVWEWYSEKIG 459 I + V + P+ + + D + +L GE + E+ Sbjct: 232 TTIAQLPVGIWTSTPSFADMAMLSDD--FCQAKMPALTHFYFDGEELTVSTARKLFERFP 289 Query: 460 KNEIPIVDTYWQTESGSHL----VTPLAGGVTPMKPGSASFPFFGIDAVVLDPNTGEELN 515 + I++ Y TE+ L +T P +P ++D + E + Sbjct: 290 SAK--IINAYGPTEATVALSAIEITREMVDNYTRLP--IGYPKPDSPTYIIDEDGKELSS 345 Query: 516 TSHAEGVLAVKAAWPSFARTIWKNHDRYLDTYLNPYPGY--YFTGDGAAKDKDGYIWILG 573 G + V P+ ++ N ++ + + + G Y TGD + +D + G Sbjct: 346 GEQ--GEIIVTG--PAVSKGYLNNPEKTAEAFF-TFKGQPAYHTGDIGSLTEDNILLYGG 400 Query: 574 RVDDVVNVSGHRLSTAEIEAAIIEDPIVAEC-AVVGFNDDLTGQAVAAFVVLKNKSSWST 632 R+D + +G+R+ ++ + + P+VA AV +N + Q + A++V+K+ Sbjct: 401 RLDFQIKYAGYRIELEDVSQQLNQSPMVASAVAVPRYNKEHKVQNLLAYIVVKDG--VKE 458 Query: 633 ATDDELQDIKKHLVFTVRKDIGPFAAPKLIILVDDLPKTRSGKIMRRIL 681 D EL ++ K + +V+ + + P + D LP T +GKI + L Sbjct: 459 RFDREL-ELTKAIKASVKDHMMSYMMPSKFLYRDSLPLTPNGKIDIKTL 506 >3E7W-A nrPDB Length = 511 Score = 240 bits (613), Expect = 1e-63, Method: Composition-based stats. Identities = 104/553 (18%), Positives = 194/553 (35%), Gaps = 63/553 (11%) Query: 136 NCVDRHALKTPNKKAIIFEGDEPGQGYSITYKELLEEVCQVAQVLTYSMGVRKGDTVAVY 195 + + HA P A QG S+TY+EL E+ + A + + K + VY Sbjct: 5 HAIQTHAETYPQTDAF------RSQGQSLTYQELWEQSDRAAAAIQKRISGEKKSPILVY 58 Query: 196 MPMVPEAIITLLAISRIGAIHSVVFAGFSSNSLRDRINDGDSKVVITTDESNRGGKVIET 255 M P I++ L + G + V S + I ++++I Sbjct: 59 GHMEPHMIVSFLGSVKAGHPYIPVDLSIPSERIAKIIESSGAELLI------------HA 106 Query: 256 KRIVDDALRETPGVRHVLVYRKTNNPSVAFHAPRDLDWATEKKKYKTYYPCTPVDSEDPL 315 + DA+ + + SV+ V + Sbjct: 107 AGLSIDAVGQQIQTVSAEELLENEGGSVSQDQW--------------------VKEHETF 146 Query: 316 FLLYTSGSTGAPKGVQHSTAGYLLGALLTMRYTFDTHQEDVFFTAGDIGWITGHTYVVYG 375 +++YTSGSTG PKGVQ S A L + F +F + + + Sbjct: 147 YIIYTSGSTGNPKGVQISAAN-LQSFTDWICADFPVSGGKIFLNQAPFSF--DLSVMDLY 203 Query: 376 PLLYGCATLVFEGTPAYPNYSRYWDIIDEHKVTQFYVAPTALRLLKRAGDSYIENHSLKS 435 P L TL A ++ + + + + P+ +++ D L Sbjct: 204 PCLQSGGTLHCVTKDAVNKPKVLFEELKKSGLNVWTSTPSFVQMCLM--DPGFSQDLLPH 261 Query: 436 LRCLGSVGEPIAAEVWEWYSEKIGKNEIPIVDTYWQTES----GSHLVTPLAGGVTPMKP 491 GE + V + E+ K + I +TY TE+ S +T + P Sbjct: 262 ADTFMFCGEVLPVSVAKALLERFPKAK--IFNTYGPTEATVAVTSVEITNDVISRSESLP 319 Query: 492 GSASFPFFGIDAVVLDPNTGEELNTSHAEGVLAVKAAWPSFARTIWKNHDRYLDTYLNPY 551 F ++ ++D G+ L +G + + PS +R + + + Sbjct: 320 --VGFAKPDMNIFIMD-EEGQPLPEGE-KGEIVIAG--PSVSRGYLGEPELTEKAFFSHE 373 Query: 552 PGY-YFTGDGAAKDKDGYIWILGRVDDVVNVSGHRLSTAEIEAAIIEDPIVAECAVVGFN 610 + Y TGD +DG I+ GR+D + + G+R+ EIE + + V V+ + Sbjct: 374 GQWAYRTGDAGFI-QDGQIFCQGRLDFQIKLHGYRMELEEIEFHVRQSQYVRSAVVIPYQ 432 Query: 611 DDLTGQAVAAFVVLKNKSSWSTATDDELQDIKKHLVFTVRKDIGPFAAPKLIILVDDLPK 670 + T + + A +V + + + + + + P+ I D + Sbjct: 433 PNGTVEYLIAAIVPEEHEFEKEF------QLTSAIKKELAASLPAYMIPRKFIYQDHIQM 486 Query: 671 TRSGKIMRRILRK 683 T +GKI R+ + + Sbjct: 487 TANGKIDRKRIGE 499 >3FCE-A nrPDB Length = 512 Score = 222 bits (566), Expect = 3e-58, Method: Composition-based stats. Identities = 95/549 (17%), Positives = 192/549 (34%), Gaps = 58/549 (10%) Query: 136 NCVDRHALKTPNKKAIIFEGDEPGQGYSITYKELLEEVCQVAQVLTYSMGVRKGDT--VA 193 +++ A +TP++ A ++ + ITYK+L E+ +A ++ D + Sbjct: 5 EQIEKWAAETPDQTAFVW------RDAKITYKQLKEDSDALAHWISSE---YPDDRSPIM 55 Query: 194 VYMPMVPEAIITLLAISRIGAIHSVVFAGFSSNSLRDRINDGDSKVVITTDESNRGGKVI 253 VY M PE II L + G + V ++ ++ + +K++++ Sbjct: 56 VYGHMQPEMIINFLGCVKAGHAYIPVDLSIPADRVQRIAENSGAKLLLSA---------- 105 Query: 254 ETKRIVDDALRETPGVRHVLVYRKTNNPSVAFHAPRDLDWATEKKKYKTYYPCTPVDSED 313 + + P V + + N + F + T P V ++ Sbjct: 106 -----TAVTVTDLP----VRIVSEDNLKDIFFTHKGN-----------TPNPEHAVKGDE 145 Query: 314 PLFLLYTSGSTGAPKGVQHSTAGYLLGALLTMRYTFDTHQEDVFFTAGDIGWITGHTYVV 373 +++YTSGSTG PKGVQ + L+ F+ VF + + + Sbjct: 146 NFYIIYTSGSTGNPKGVQITY-NCLVSFTKWAVEDFNLQTGQVFLNQAPFSF--DLSVMD 202 Query: 374 YGPLLYGCATLVFEGTPAYPNYSRYWDIIDEHKVTQFYVAPTALRLLKRAGDSYIENHSL 433 P L TL + +++ + + P+ + L Sbjct: 203 IYPSLVTGGTLWAIDKDMIARPKDLFASLEQSDIQVWTSTPSFAEMCLMEAS--FSESML 260 Query: 434 KSLRCLGSVGEPIAAEVWEWYSEKIGKNEIPIVDTYWQTESGSHLVTPLAGGVTPMKPGS 493 +++ GE + EV E+ K I++TY TE+ + + S Sbjct: 261 PNMKTFLFCGEVLPNEVARKLIERFPKA--TIMNTYGPTEATVAVTGIHVTEEVLDQYKS 318 Query: 494 ASFPFFGIDAVVLDPNTGEELNTSHAEGVLAVKAAWPSFARTIWKNHDRYLDTY-LNPYP 552 + D +L + +G + + PS + + + + + Sbjct: 319 LPVGYCKSDCRLLIMKEDGTIAPDGEKGEIVIVG--PSVSVGYLGSPELTEKAFTMIDGE 376 Query: 553 GYYFTGDGAAKDKDGYIWILGRVDDVVNVSGHRLSTAEIEAAIIEDPIVAECAVVGFNDD 612 Y TGD ++G ++ GR+D + + G+R+ EIE + V +V Sbjct: 377 RAYKTGDAGYV-ENGLLFYNGRLDFQIKLHGYRMELEEIEHHLRACSYVEGAVIVPIKKG 435 Query: 613 LTGQAVAAFVVLKNKSSWSTATDDELQDIKKHLVFTVRKDIGPFAAPKLIILVDDLPKTR 672 + A VV S + + + + + + P+ + +P T Sbjct: 436 EKYDYLLAVVVPGEHSFEKEFK------LTSAIKKELNERLPNYMIPRKFMYQSSIPMTP 489 Query: 673 SGKIMRRIL 681 +GK+ R+ L Sbjct: 490 NGKVDRKKL 498 >4R0M-B nrPDB Length = 643 Score = 215 bits (547), Expect = 6e-56, Method: Composition-based stats. Identities = 88/530 (16%), Positives = 184/530 (34%), Gaps = 46/530 (8%) Query: 165 TYKELLEEVCQVAQVLTYSMGVRKGDTVAVYMPMVPEAIITLLAISRIGAIHSVVFAGFS 224 +Y++L ++ + L G++ G V + + + I L A G I + S Sbjct: 47 SYQDLYQDALVILNGLEQK-GIKLGHKVILQIAKNQDFIPALWACFLGGIIPVPLTVAPS 105 Query: 225 SNSLRDRINDGDSKVVITTDESNRGGKVIETKRIVDDALRETPGVRHVLVYRKTNNPSVA 284 + + K + + ++ ++ + + Sbjct: 106 -----YDLENSAVKKLENVWKILDNPLILSDSELITEIEKL--------------GTYSH 146 Query: 285 FHAPRDLDWATEKKKYKTYYPCTPVDSEDPLFLLYTSGSTGAPKGVQHSTAGYLLGALLT 344 + + +K +D +D LL+TSGSTG PKGV + L T Sbjct: 147 LEGWQVISVNELRKAPSKIEQLPILDPQDAALLLFTSGSTGMPKGVILTHHNILSMTAGT 206 Query: 345 MRYTFDTHQEDVFFTAGDIGWITGHTYVVYGPLLYGCATLVFEGTPAYPNYSRYWDIIDE 404 + Q++V + + ++ + C + ++ ++I + Sbjct: 207 VVMN-HFTQQEVTLNWMPLDHVGAIVFLGIMAVDLACDQIHVPMELVLRQPLQWLELIQK 265 Query: 405 HKVTQFYVAPTALRLLKRAGDSYIE-NHSLKSLRCLGSVGEPIAAEVWEWYSEKIGKNEI 463 H+V+ + A L+ + + +++L S++ L + GE ++ + + E + K+++ Sbjct: 266 HQVSISWSPNFAFSLINQQAEELKHVSYNLSSMKFLVNAGEQVSVKTIRLFLEILEKHQL 325 Query: 464 ---PIVDTYWQTESGSHLVTPLAGGVTPMKPG----SASFPFFGIDAVVLDPNTGEELNT 516 I + TES S + + S P G ++D Sbjct: 326 QERAIKPAFGMTESCSGITWSAGLSKNELTEENSFVSLGKPIPGATIRIVDQENNPLPER 385 Query: 517 SHAEGVLAVKAAWPSFARTIWKNHDRYLDTYLNPYPGYYFTGDGAAKDKDGYIWILGRVD 576 + S + + N++ + + G++ TGD K G ++I GR Sbjct: 386 EIGRLQI----QGNSVTKGYYNNNELNQEVFQ---EGWFTTGDLGYLSK-GELFITGREK 437 Query: 577 DVVNVSGHRLSTAEIEAAIIEDPI--VAECAVVGFNDDLTGQAVAAFVVLKNKSSWSTAT 634 + ++G E+E I E V+ A D + + +S Sbjct: 438 QEIIINGVNYFAHELETTIEELEGVKVSYTAAFAVFDQSR-ETDLLIITFSPESEQFEQG 496 Query: 635 DDELQDIKKHLVFTVRKDIGP-FAAPKLIILVDDLPKTRSGKIMRRILRK 683 ++ I+ H+ + I P + P LV PKT GK+ + L+K Sbjct: 497 IKVVRKIRSHVTQ--KFGIAPAYVIPLERNLV---PKTSIGKVQKSKLKK 541 >3PBK-A nrPDB Length = 583 Score = 193 bits (490), Expect = 2e-49, Method: Composition-based stats. Identities = 92/594 (15%), Positives = 174/594 (29%), Gaps = 91/594 (15%) Query: 129 GQLNACYNCVDRHALKTPNKKAIIFEGDEPGQGYSITYKELLEEVCQVAQVLTYSMGVRK 188 + +D AL + + F + Y+ L A+ L S+ ++K Sbjct: 17 ADFPTLVDALDYAALSS---AGMNFYDRRCQLEDQLEYQTLKARAEAGAKRLL-SLNLKK 72 Query: 189 GDTVAVYMPMVPEAIITLLAISRIGAIHSVVFAGFS-------SNSLRDRINDGDSKVVI 241 GD VA+ E + A G + + S L+ + +I Sbjct: 73 GDRVALIAETSSEFVEAFFACQYAGLVAVPLAIPMGVGQRDSWSAKLQGLLASCQPAAII 132 Query: 242 TTDESNRGGKVIETKRIVDDALRETPGVRHVLVYRKTNNPSVAFHAPRDLDWATEKKKYK 301 T DE +V+ A + P + H + + Sbjct: 133 TGDEWLP---------LVNAATHDNPEL----------------HVLSHAWFKALPEADV 167 Query: 302 TYYPCTPVDSEDPLFLLYTSGSTGAPKGVQHSTAGYLLGALLTMRYTFDTHQEDVFFTAG 361 D +L YTSGST P+GV + + D + Sbjct: 168 ALQRPV---PNDIAYLQYTSGSTRFPRGVIITHREVMANLRAISHDGIKLRPGDRCVSWL 224 Query: 362 DIGWITGHTYVVYGPLLYGCATLVFEGTPAYPNYSRYWDIIDEHKVTQFYVAPTALRLLK 421 G + P+ + ++ +I +++ T P L + Sbjct: 225 PFYHDMGLVGFLLTPVATQLSVDYLRTQDFAMRPLQWLKLISKNRGTVSVAPPFGYELCQ 284 Query: 422 RAGDSY-IENHSLKSLRCLGSVGEPIAAEVWEWYSEKIGKNEIP---IVDTYWQ------ 471 R + + L R G EPI+AE ++E + + Y Sbjct: 285 RRVNEKDLAELDLSCWRVAGIGAEPISAEQLHQFAECFRQVNFDNKTFMPCYGLAENALA 344 Query: 472 ----TESGSHLVTPLAGGVTP-----MKPGS----------ASFPFFGIDAVVLDPNTGE 512 E+ +V + + + PG+ + + Sbjct: 345 VSFSDEASGVVVNEVDRDILEYQGKAVAPGAETRAVSTFVNCGKALPEHGIEIRNEAGMP 404 Query: 513 ELNTSHAEGVLAVKAAWPSFARTIWKNHDRYLDTYLNPYPGYYFTGDGAAKDKDGYIWIL 572 + + PS + + + G+ TGD DGY+++ Sbjct: 405 VAERVVGH--ICISG--PSLMSGYFGDQVSQDEIAAT---GWLDTGDLGYLL-DGYLYVT 456 Query: 573 GRVDDVVNVSGHRLSTAEIEAAIIEDPIVAECAVVGFNDDLTGQAVAAFVVLKNKSSWST 632 GR+ D++ + G + +IE ++P + + AFV + K Sbjct: 457 GRIKDLIIIRGRNIWPQDIEYIAEQEPEIHSGDAI------------AFVTAQEKIILQI 504 Query: 633 ATDDELQDIKKHLVFTVRKDI-GPFAAPKLIILVD--DLPKTRSGKIMRRILRK 683 ++ + L+ + I F I L+ +P+T SGK R +K Sbjct: 505 QCRISDEERRGQLIHALAARIQSEFGVTAAIDLLPPHSIPRTSSGKPARAEAKK 558 >5EY8-A nrPDB Length = 630 Score = 177 bits (448), Expect = 1e-44, Method: Composition-based stats. Identities = 106/641 (16%), Positives = 186/641 (29%), Gaps = 110/641 (17%) Query: 117 RPSFQNNA-WFLNGQLNACYNCVDRHALKTPNKKA---IIFEGDEPGQGYSITYKELLEE 172 P ++ F +G + V+R A +K A + F + G +T+ + Sbjct: 5 NPFIKDGQIKFPDGSSIVAH--VERWAKVRGDKLAYRFLDFSTERDGVPRDLTWAQFSAR 62 Query: 173 VCQVAQVLTYSMGVRKGDTVAVYMPMVPEAIITLLAISRIGAIHSVVFAGFSSN---SLR 229 VA L + GD VA+ P + ++ G I +F L Sbjct: 63 NRAVAARLQQV--TQPGDRVAILCPQNLDYLVAFFGALYAGRIAVPLFDPSEPGHVGRLH 120 Query: 230 DRINDGDSKVVITTDESNRGGKVIETKRIVDDALRETPGVRHVLVYRKTNNPSVAFHAPR 289 +++ ++TT E+ G V R P + V P Sbjct: 121 AVLDNCHPSAILTTTEAAEG---------VRKFFRTRPANQRPRVIAVDAVPDDVASTWV 171 Query: 290 DLDWATEKKKYKTYYPCTPVDSEDPLFLLYTSGSTGAPKGVQHSTAGYLLGALLTMRYTF 349 + D E +L YTSGST P GVQ + + + Sbjct: 172 NPDEPDETT---------------IAYLQYTSGSTRIPTGVQITHLNLATNVVQVIE-AL 215 Query: 350 DTHQEDVFFTAGDIGWITGHTYVVYGPLLYGCATLVFEGTPAYPNYSRYWDIIDE----H 405 + + D + G + P++ T R+ + Sbjct: 216 EGEEGDRGLSWLPFFHDMGLITALLAPMIGHYFTF-MTPAAFVRRPERWIRELARKEGDT 274 Query: 406 KVTQFYVAPTALRLLKRAGDSYI--ENHSLKSLRCLGSVGEPIAAEVWEWYSEKIGKNEI 463 T A G L +++ + + EPI+A ++E G Sbjct: 275 GGTISVAPNFAFDHAAARGVPKPGSPPLDLSNVKAVLNGSEPISAATVRRFNEAFGPFGF 334 Query: 464 P---IVDTYWQTESGSHLVTPLAGGVTP-------------------------MKPGSAS 495 P I +Y E+ + V+ P + SA Sbjct: 335 PPKAIKPSYGLAEA-TLFVSTTPSAEEPKIITVDRDQLNSGRIVEVDADSPKAVAQASAG 393 Query: 496 FPFFGIDAVVLDPNTGEELNTSHAEGVLAVKAAWPSFARTIWKNHDRYLDTYLN------ 549 AV++D + EL G + + + W + + T+ N Sbjct: 394 KVGIAEWAVIVDAESATELPDGQV-GEIWISGQ--NMGTGYWGKPEESVATFQNILKSRT 450 Query: 550 ---------PYPGYYFTGDGAAKDKDGYIWILGRVDDVVNVSGHRLSTAEIE-AAIIEDP 599 + TGD A DG ++I GRV D+V + G ++E +A Sbjct: 451 NPSHAEGATDDATWVRTGDYGAF-YDGDLYITGRVKDLVIIDGRNHYPQDLEYSAQEASK 509 Query: 600 IVAECAVVG-------FNDDLTGQAVAAFVVLKNKSSWST---ATDDELQDIKKHLVFTV 649 + V D++ + + + + + K + Sbjct: 510 AIRTGYVAAFSVPANQLPDEVF-ENAHSGIKRDPDDTSEQLVIVAERAPGAHKLDIGPIT 568 Query: 650 RKDIGPFAAPKLIILVD-------DLPKTRSGKIMRRILRK 683 A + + D +P+T SGKI RR R Sbjct: 569 DDIRAAIAVRHGVTVRDVLLTAAGAIPRTSSGKIGRRACRA 609 >5JNF-C nrPDB Length = 587 Score = 175 bits (444), Expect = 5e-44, Method: Composition-based stats. Identities = 77/445 (17%), Positives = 148/445 (33%), Gaps = 68/445 (15%) Query: 135 YNCVDRHALKTPNKKAIIFEGDEPGQGYSITYKELLEEVCQVAQVLTYSMGVRKGDTVAV 194 + ++ TP+ A++ +G S+TYK+L E Q+A L GV+ D VA+ Sbjct: 208 HQLFEQQVEMTPDHVAVV------DRGQSLTYKQLNERANQLAHHLRGK-GVKPDDQVAI 260 Query: 195 YMPMVPEAIITLLAISRIGAIHSVVFAGFSSNSLRDRINDGDSKVVITTDESNRGGKVIE 254 + + I+++LA+ + G + + + + + D + +++T Sbjct: 261 MLDKSLDMIVSILAVMKAGGAYVPIDPDYPGERIAYMLADSSAAILLTNA---------- 310 Query: 255 TKRIVDDALRETPGVRHVLVYRKTNNPSVAFHAPRDLDWATEKKKYKTYYPCTPVDSEDP 314 ++ + N + D D +E + +D Sbjct: 311 -------------------LHEEKANGACDIIDVHDPDSYSENTNNLPHVN----RPDDL 347 Query: 315 LFLLYTSGSTGAPKGVQHSTAGYLLGALLTMRYTFDTHQEDVFFTAGDIGWITGHTYVVY 374 ++++YTSGSTG KGV L+ R F D + G ++ Sbjct: 348 VYVMYTSGSTGLAKGVMIEHHN-LVNFCEWYRPYFGVTPADKALVYSSFSF-DGSALDIF 405 Query: 375 GPLLYGCATLVFEGTPAYPNYSRYWDIIDEHKVTQFYVAPTALRLLKRAGDSYIENHSLK 434 LL G A + Y + D ++ +T Y+ A + + + Sbjct: 406 THLLAGAALHIVPSERKY-DLDALNDYCNQEGITISYLPTGAAEQFMQMDN--------Q 456 Query: 435 SLRCLGSVGEPIAAEVWEWYSEKIGKNEIPIVDTYWQTESGSHLVTPLAGGVTPMKPGSA 494 S R + + G + + + + Y TE ++ + P Sbjct: 457 SFRVVITGG--------DVLKKIERNGTYKLYNGYGPTEC--TIMVTMFEVDKPYANIPI 506 Query: 495 SFPFFGIDAVVLDPNTGEELNTSHAEGVLAVKAAWPSFARTIWKNHDRYLDTYL---NPY 551 P ++LD + E + + R + + ++ Sbjct: 507 GKPIDRTRILILDEALALQPIGVAGELFIVGEG----LGRGYLNRPELTAEKFIVHPQTG 562 Query: 552 PGYYFTGDGAAKDKDGYIWILGRVD 576 Y TGD A DG I LGR+D Sbjct: 563 ERMYRTGDRARFLPDGNIEFLGRLD 587 >6NJ0-A nrPDB Length = 451 Score = 163 bits (412), Expect = 2e-40, Method: Composition-based stats. Identities = 102/554 (18%), Positives = 178/554 (32%), Gaps = 113/554 (20%) Query: 136 NCVDRHALKTPNKKAIIFEGDEPGQGYSITYKELLEEVCQVAQVLTYSMGVRKGDTVAVY 195 + RH + + + DE + ++EL V ++A GV +G V + Sbjct: 5 DWPWRHWRQVRGETIALRLNDE-----QLNWRELCARVDELASGFAV-QGVVEGSGVMLR 58 Query: 196 MPMVPEAIITLLAISRIGAIHSVVFAGFSSNSLRDRINDGDSKVVITTDESNRGGKVIET 255 P+ ++ LA+ + GA V L + + + + + D N + Sbjct: 59 AWNTPQTLLAWLALLQCGARVLPVNPQLPQPLLEELLPNLTLQFALVPDGENTFPALTSL 118 Query: 256 KRIVDDALRETPGVRHVLVYRKTNNPSVAFHAPRDLDWATEKKKYKTYYPCTPVDSEDPL 315 + E T+ P Sbjct: 119 HIQL-----------------------------------VEGAHAATWQPTR------LC 137 Query: 316 FLLYTSGSTGAPKGVQHSTAGYLLGALLTMRYTFDTHQEDVFFTAGDIGWITGHTYVVYG 375 + TSGSTG PK H+ +L A + +D + + + ++G +++ Sbjct: 138 SMTLTSGSTGLPKAAVHTYQAHLASAQGVLSLIPFGDHDD-WLLSLPLFHVSGQG-IMWR 195 Query: 376 PLLYGCATLVFEGTPAYPNYSRYWDIIDEHKVTQFYVAPT-ALRLLKRAGDSYIENHSLK 434 L G V + P + T + PT RLL N S Sbjct: 196 WLYAGARMTVRDKQPL----EQML-----AGCTHASLVPTQLWRLLV--------NRSSV 238 Query: 435 SLRCLGSVGEPIAAEVWEWYSEKIGKNEIPIVDTYWQTESGSHLVTPLAGGVTPMKPGSA 494 SL+ + G I E+ E E+ I Y TE S + A G+ Sbjct: 239 SLKAVLLGGAAIPVELTEQAREQ----GIRCFCGYGLTEFASTVCAKEADGLA-----DV 289 Query: 495 SFPFFGIDAVVLDPNTGEELNTSHAEGVLAVKAAWPSFARTIWKNHDRYLDTYLNPYPGY 554 P G + +++ V S A W+N L + +N G+ Sbjct: 290 GSPLPGREVKIVNNE---------------VWLRAASMAEGYWRNGQ--LVSLVND-EGW 331 Query: 555 YFTGDGAAKDKDGYIWILGRVDDVVNVSGHRLSTAEIEAAIIEDPIVAECAVVGFNDDLT 614 Y T D +G + I+GR+D++ G + E+E I P V + +V D Sbjct: 332 YATRDRGEM-HNGKLTIVGRLDNLFFSGGEGIQPEEVERVIAAHPAVLQVFIVPVADKEF 390 Query: 615 GQAVAAFVVLKNKSSWSTATDDELQDIKKHLVFTVRKDIGPFAAPKLIILVDDLPKTRSG 674 G A + E L V+ + F P + + P+ ++G Sbjct: 391 GHRPVAVM--------------EYDHESVDLSEWVKDKLARFQQPVRWLTLP--PELKNG 434 Query: 675 --KIMRRILRKILA 686 KI R+ L++ + Sbjct: 435 GIKISRQALKEWVQ 448 >5HM3-A nrPDB Length = 657 Score = 156 bits (394), Expect = 3e-38, Method: Composition-based stats. Identities = 102/621 (16%), Positives = 178/621 (28%), Gaps = 112/621 (18%) Query: 138 VDRHALKTPNKKA---IIFEGDEPGQGYSITYKELLEEVCQVAQVLTYSMGVRKGDTVAV 194 V++ A +K A + F + G I + + V L + GD VA+ Sbjct: 53 VEKWAKVRGDKLAYRFLDFSTERDGVARDILWSDFSARNRAVGARLQQV--TQPGDRVAI 110 Query: 195 YMPMVPEAIITLLAISRIGAIHSVVFAGFSSNS------LRDRINDGDSKVVITTDESNR 248 P + +I+ G I + F L ++D ++TT +S Sbjct: 111 LCPQNLDYLISFFGALYSGRIAVPL---FDPAEPGHVGRLHAVLDDCAPSTILTTTDSAE 167 Query: 249 GGKVIETKRIVDDALRETPGVRHVLVYRKTNNPSVAFHAPRDLDWATEKKKYKTYYPCTP 308 G + R A PR + + + Sbjct: 168 GVRKFIRAR-------------------------SAKERPRVIAVDAVPTEVAATWQQPE 202 Query: 309 VDSEDPLFLLYTSGSTGAPKGVQHSTAGYLLGALLTMRYTFDTHQEDVFFTAGDIGWITG 368 + E +L YTSGST P GVQ + + + + + D + G Sbjct: 203 ANEETVAYLQYTSGSTRIPSGVQITHLNLPTNVV-QVLNALEGQEGDRGVSWLPFFHDMG 261 Query: 369 HTYVVYGPLLYGCATLVFEGTPAYPNYSRYWDIIDE----HKVTQFYVAPTALRLLKRAG 424 V+ +L G + R+ + T A G Sbjct: 262 LITVLLASVL-GHSFTFMTPAAFVRRPGRWIRELARKPGETGGTFSAAPNFAFEHAAVRG 320 Query: 425 DSYIENH--SLKSLRCLGSVGEPIAAEVWEWYSEKI---GKNEIPIVDTYWQTESGSHLV 479 + L +++ + + EP++ + E G + + +Y E+ + V Sbjct: 321 VPRDDEPPLDLSNVKGILNGSEPVSPASMRKFFEAFAPYGLKQTAVKPSYGLAEA-TLFV 379 Query: 480 TPLAGGVTPM--------------------KPG-----SASFPFFGIDAVVLDPNTGEEL 514 + P P SA AV++D +T EL Sbjct: 380 STTPMDEVPTVIHVDRDELNNQRFVEVAADAPNAVAQVSAGKVGVSEWAVIVDADTASEL 439 Query: 515 NTSHAEGVLAVKAAWPSFARTIWKNHDRYLDTYLN---------------PYPGYYFTGD 559 G + + + W + T+ N + TGD Sbjct: 440 PDGQI-GEIWLHGN--NLGTGYWGKEEESAQTFKNILKSRISESRAEGAPDDALWVRTGD 496 Query: 560 GAAKDKDGYIWILGRVDDVVNVSGHRLSTAEIEAAIIEDPI---VAECAVVGFNDDLTGQ 616 KD +++I GR+ D+V + G ++E E V A + Q Sbjct: 497 YGTYFKD-HLYIAGRIKDLVIIDGRNHYPQDLECTAQESTKALRVGYAAAFSVPANQLPQ 555 Query: 617 AV----AAFVVLKNKSSWSTAT---DDELQDIKKHLVFTVRKDIGPFAAPKLIILVD--- 666 V A + + + + K V A + + D Sbjct: 556 TVFDDSHAGLKFDPEDTSEQLVIVGERAAGTHKLDHQPIVDDIRAAIAVGHGVTVRDVLL 615 Query: 667 ----DLPKTRSGKIMRRILRK 683 +P+T SGKI RR R Sbjct: 616 VSAGTIPRTSSGKIGRRACRA 636 >5EY9-A nrPDB Length = 629 Score = 153 bits (386), Expect = 3e-37, Method: Composition-based stats. Identities = 107/653 (16%), Positives = 189/653 (28%), Gaps = 130/653 (19%) Query: 110 IPDPKTGRPSFQNNAWFLNGQLNACYNCVDRHALKTPNKKA---IIFEGDEPGQGYSITY 166 P G+ F N V++ A +K A + F + G I + Sbjct: 5 NPFIVNGKIRFPEN--------TNLVRHVEKWARVRGDKLAYRFLDFSTERDGVERDILW 56 Query: 167 KELLEEVCQVAQVLTYSMGVRKGDTVAVYMPMVPEAIITLLAISRIGAIHSVVFAGFSSN 226 E V L + GD +A+ P + +I+ G I + F Sbjct: 57 SEFSARNRAVGARLQQV--TQPGDRIAILCPQNLDYLISFFGALYSGRIAVPL---FDPA 111 Query: 227 S------LRDRINDGDSKVVITTDESNRGGKVIETKRIVDDALRETPGVRHVLVYRKTNN 280 L ++D ++TT +S G + R Sbjct: 112 EPGHVGRLHAVLDDCTPSTILTTTDSAEGVRKFIRSR----------------------- 148 Query: 281 PSVAFHAPRDLDWATEKKKYKTYYPCTPVDSEDPLFLLYTSGSTGAPKGVQHSTAGYLLG 340 A PR + + + + + +L YTSGST P GVQ + Sbjct: 149 --SAKERPRVIAVDAVPTEVASTWQQPEANELTTAYLQYTSGSTRVPSGVQITHLNLPTN 206 Query: 341 ALLTMRYTFDTHQEDVFFTAGDIGWITGHTYVVYGPLLYGCATLVFEGTPAYPNYSRYWD 400 +L + + + D + G V+ +L G + R+ Sbjct: 207 -VLQVLNALEGQEGDRGVSWLPFFHDMGLITVLLASVL-GHSFTFMTPAAFVRRPGRWIR 264 Query: 401 IIDE----HKVTQFYVAPTAL--RLLKRAGDSYIENHSLKSLRCLGSVGEPIAAEVWEWY 454 + T A ++ L +++ + + EP++ + Sbjct: 265 ELARKPGETGGTFSAAPNFAFEHAAMRGVPRDDEPPLDLSNVKGILNGSEPVSPASMRKF 324 Query: 455 SEKI---GKNEIPIVDTYWQTESGSHLVTPLAGGVTPM--------------------KP 491 + G E + +Y E+ + V+ P P Sbjct: 325 FKAFEPYGLRETAVKPSYGLAEA-TLFVSTTPMDEVPTVIHVDRDELNKQRFVEVAADAP 383 Query: 492 G-----SASFPFFGIDAVVLDPNTGEELNTSHAEGVLAVKAAWPSFARTIWKNHDRYLDT 546 SA AV++D T EL G + + + W + T Sbjct: 384 NAVAQVSAGKVGVDEWAVIVDTETASELPDGQI-GEIWLHGN--NLGIGYWGKEEESAQT 440 Query: 547 YLN--------------PYPG-YYFTGDGAAKDKDGYIWILGRVDDVVNVSGHRLSTAEI 591 + N P G + TGD K G+++I GR+ D+V + G ++ Sbjct: 441 FRNILKSRVPESHAEGAPDDGLWVRTGDYGTYFK-GHLYIAGRIKDLVIIDGRNHYPQDL 499 Query: 592 EAAIIEDPI---VAECAVVGFN----------DDLTG-------QAVAAFVVLKNKSSWS 631 E E V A D G + +V + + Sbjct: 500 EYTAQESTKALRVGYVAAFSVPANQLPQKVFDDPHAGLSFDPEDTSEQLVIVGERAAGTH 559 Query: 632 TATDDELQDIKKHLVFTVRKDIGPFAAPKLIILVDD--LPKTRSGKIMRRILR 682 + D + + +G + ++LV +P+T SGKI RR R Sbjct: 560 KLEYQPIADDIRAAIA-----VGHGVTVRDVLLVSAGTIPRTSSGKIGRRACR 607 >5D6N-A nrPDB Length = 508 Score = 152 bits (383), Expect = 5e-37, Method: Composition-based stats. Identities = 87/515 (16%), Positives = 149/515 (28%), Gaps = 91/515 (17%) Query: 117 RPSFQNNA-WFLNGQLNACYNCVDRHALKTPNKKA---IIFEGDEPGQGYSITYKELLEE 172 P ++ F +G + V+R A +K A + F + G +T+ + Sbjct: 29 NPFIKDGQIKFPDGSSIVAH--VERWAKVRGDKLAYRFLDFSTERDGVPRDLTWAQFSAR 86 Query: 173 VCQVAQVLTYSMGVRKGDTVAVYMPMVPEAIITLLAISRIGAIHSVVFAGFSSN---SLR 229 VA L + GD VA+ P + ++ G I +F L Sbjct: 87 NRAVAARLQQV--TQPGDRVAILCPQNLDYLVAFFGALYAGRIAVPLFDPSEPGHVGRLH 144 Query: 230 DRINDGDSKVVITTDESNRGGKVIETKRIVDDALRETPGVRHVLVYRKTNNPSVAFHAPR 289 +++ ++TT E+ G V R P + V P Sbjct: 145 AVLDNCHPSAILTTTEAAEG---------VRKFFRTRPANQRPRVIAVDAVPDDVASTWV 195 Query: 290 DLDWATEKKKYKTYYPCTPVDSEDPLFLLYTSGSTGAPKGVQHSTAGYLLGALLTMRYTF 349 + D E +L YTSGST P GVQ + + + Sbjct: 196 NPDEPDETT---------------IAYLQYTSGSTRIPTGVQITHLNLATNVVQVIE-AL 239 Query: 350 DTHQEDVFFTAGDIGWITGHTYVVYGPLLYGCATLVFEGTPAYPNYSRYWDIIDE----H 405 + + D + G + P++ T R+ + Sbjct: 240 EGEEGDRGLSWLPFFHDMGLITALLAPMIGHYFTF-MTPAAFVRRPERWIRELARKEGDT 298 Query: 406 KVTQFYVAPTALRLLKRAGDSYI--ENHSLKSLRCLGSVGEPIAAEVWEWYSEKIGKNEI 463 T A G L +++ + + EPI+A ++E G Sbjct: 299 GGTISVAPNFAFDHAAARGVPKPGSPPLDLSNVKAVLNGSEPISAATVRRFNEAFGPFGF 358 Query: 464 P---IVDTYWQTESGSHLVTPLAGGVTP-------------------------MKPGSAS 495 P I +Y E+ + V+ P + SA Sbjct: 359 PPKAIKPSYGLAEA-TLFVSTTPSAEEPKIITVDRDQLNSGRIVEVDADSPKAVAQASAG 417 Query: 496 FPFFGIDAVVLDPNTGEELNTSHAEGVLAVKAAWPSFARTIWKNHDRYLDTYLN------ 549 AV++D + EL G + + + W + + T+ N Sbjct: 418 KVGIAEWAVIVDAESATELPDGQV-GEIWISGQ--NMGTGYWGKPEESVATFQNILKSRT 474 Query: 550 ---------PYPGYYFTGDGAAKDKDGYIWILGRV 575 + TGD A DG ++I GRV Sbjct: 475 NPSHAEGATDDATWVRTGDYGAF-YDGDLYITGRV 508 >3E53-A nrPDB Length = 480 Score = 140 bits (352), Expect = 2e-33, Method: Composition-based stats. Identities = 93/487 (19%), Positives = 156/487 (32%), Gaps = 76/487 (15%) Query: 133 ACYNCVDRHALKTPNKKAII---FEGDEPGQGYSITYKELLEEVCQVAQVLTYSMGVRKG 189 + + A P+ A +E D G ++T+ +L VAQ L G G Sbjct: 25 SLPAALRACARLQPHDPAFTFMDYEQDWDGVAITLTWSQLYRRTLNVAQEL-SRCG-STG 82 Query: 190 DTVAVYMPMVPEAIITLLAISRIGAIHSVVFA---GFSSNSLRDRINDGDSKVVITTDES 246 D V + P E ++ L + G I + G + ++D ++TT + Sbjct: 83 DRVVISAPQGLEYVVAFLGALQAGRIAVPLSVPQGGVTDERSDSVLSDSSPVAILTTSSA 142 Query: 247 NRGGKVIETKRIVDDALRETPGVRHVLVYRKTNNPSVAFHAPRDLDWATEKKKYKTYYPC 306 VDD V+HV + PS+ DLD + YP Sbjct: 143 ------------VDDV------VQHVARRPGESPPSIIEVDLLDLDAPNGYTFKEDEYPS 184 Query: 307 TPVDSEDPLFLLYTSGSTGAPKGVQHSTAGYLLG-ALLTMRYTFDTH----QEDVFFTAG 361 T +L YTSGST P GV S + L Y DT + Sbjct: 185 T-------AYLQYTSGSTRTPAGVVMSHQNVRVNFEQLMSGYFADTDGIPPPNSALVSWL 237 Query: 362 DIGWITGHTYVVYGPLLYGCATLVFEGTPAYPNYSRYWDIIDEHKVTQFYVAPTALRL-L 420 G + P+L G ++ +R+ ++ A L Sbjct: 238 PFYHDMGLVIGICAPILGGYPAVLTSPVSFLQRPARWMHLMASDFHAFSAAPNFAFELAA 297 Query: 421 KRAGDSYIENHSLKSLRCLGSVGEPIAAEVWEWYSEKIGKNEIP---IVDTYWQTESGSH 477 +R D + L ++ + S E + A + ++++ + + I +Y E+ + Sbjct: 298 RRTTDDDMAGRDLGNILTILSGSERVQAATIKRFADRFARFNLQERVIRPSYGLAEATVY 357 Query: 478 LVTPLAGGVTPM-------------KPGSASFPFFGID--------AVVLDPNTGEELNT 516 + T G KP + I ++D +T E Sbjct: 358 VATSKPGQPPETVDFDTESLSAGHAKPCAGGGATSLISYMLPRSPIVRIVDSDTCIECPD 417 Query: 517 SHAEGVLAVKAAWPSFARTIWKNHDRYLDTYLN---------PYPGYYFTGDGAAKDKDG 567 G + V + A W+ D T+ P + TGD DG Sbjct: 418 GTV-GEIWVHG--DNVANGYWQKPDESERTFGGKIVTPSPGTPEGPWLRTGDSGFVT-DG 473 Query: 568 YIWILGR 574 ++I+GR Sbjct: 474 KMFIIGR 480 >4RVO-A nrPDB Length = 436 Score = 107 bits (266), Expect = 2e-23, Method: Composition-based stats. Identities = 81/420 (19%), Positives = 139/420 (33%), Gaps = 36/420 (8%) Query: 273 LVYRKTNNPSVAFHAPRDLDWA--TEKKKYKTYYPCTPVDSE---DPLFLLYTSGSTGAP 327 V+ K + + D+ T K + YP V + D + + +SG+TG P Sbjct: 42 EVFSKNGITGDSIQSLDDIRKIPFTTKSDMRANYPFGLVAGDMKRDGVRIHSSSGTTGNP 101 Query: 328 KGVQHSTAGYLLGALLTMR--YTFDTHQEDVFFTAGDIGWITGHTYVVYGPLLYGCATLV 385 + HS A L R Y + DVF + G TG YG GC T+ Sbjct: 102 TVIVHSQHDLDSWANLVARCLYMVGIRKTDVFQNSSGYGMFTGGLGFQYGAERLGCLTV- 160 Query: 386 FEGTPAYPNYSRYWDIIDEHKVTQFYVAPTALRLLKRAGDSYIENHSLKSLRCLGSVGEP 445 A N R I + K T + P+ L + +L+ L EP Sbjct: 161 ---PAAAGNSKRQIKFISDFKTTALHAIPSYAIRLAEVFQEEGIDPRETTLKTLVIGAEP 217 Query: 446 IAAEVWEWYSEKIGKNEIPIVDTYWQTESGSHLVTPLAGGVTPMKPGSASFPFFGIDAVV 505 E + + +++ TE V M + Sbjct: 218 HTDEQRRKIERML---NVKAYNSFGMTEMNGPGVAFECQEQNGMHFWE-----DCYLVEI 269 Query: 506 LDPNTGEELNTSHAEGVLAVKAAWPSFARTIWKNHDRYLDTYLNPYPGYYFTGDGAAKDK 565 +DP TGE + ++ ++ D G D Sbjct: 270 IDPETGEPVPEGEIGELVLTTLDREMMPLIRYRTRDLTRILPGKCPCGRTHL----RID- 324 Query: 566 DGYIWILGRVDDVVNVSGHRLSTAEIEAAIIEDPIVAECAVVGFNDDLTGQAVAAFVVLK 625 I GR DD+ + G + ++E +++ P + ++ + +V Sbjct: 325 ----RIKGRSDDMFIIKGVNIFPMQVEKILVQFPELGSNYLITLETVNNQDEM---IVEV 377 Query: 626 NKSSWSTATDDELQDIKKHLVFTVRKDIGPFAAPK-LIILVDDLPKTRSGKIMR-RILRK 683 S ST EL+ I++ ++ ++ +I PK ++ LP+ GK +R + LR Sbjct: 378 ELSDLSTDNYIELEKIRRDIIRQLKDEI--LVTPKVKLVKKGSLPQ-SEGKAVRVKDLRD 434 >2Y4O-A nrPDB Length = 443 Score = 101 bits (251), Expect = 1e-21, Method: Composition-based stats. Identities = 74/390 (18%), Positives = 133/390 (34%), Gaps = 33/390 (8%) Query: 302 TYYPCTPVDSEDPLFLLYTSGSTGAPKGVQHSTAGYLLGALLTMRY--TFDTHQEDVFFT 359 + V E + + +SG+TG P V ++ A +T R D Sbjct: 82 YPFGLFAVPREQVVRVHASSGTTGKPTVVGYTARDIDTWANVTARSIRAAGGRPGDTLHN 141 Query: 360 AGDIGWITGHTYVVYGPLLYGCATLVFEGTPAYPNYSRYWDIIDEHKVTQFYVAPTALRL 419 A G TG + YG GC + G + +I + + V P+ + Sbjct: 142 AFGYGLFTGGLGIHYGAERLGCMVVPMSG----GQTEKQVQLIRDFEPKIILVTPSYMLN 197 Query: 420 LKRAGDSYIENHSLKSLRCLGSVGEPIAAEVWEWYSEKIGKNEIPIVDTYWQTESGSHLV 479 L + + SL+ EP + ++G I +D Y +E V Sbjct: 198 LIDEMVRQGMDPAESSLKIGIFGAEPWTQALRNEVETRVG---IDALDIYGLSEVMGPGV 254 Query: 480 TPLAGGVTPMKPGSASFPFFGID---AVVLDPNTGEELNTSHAEGVLAVKAAWPSFARTI 536 K G P D ++DP TGE L ++G L + I Sbjct: 255 AC---ECVETKDG----PVIWEDHFYPEIIDPVTGEVLPDG-SQGELVFTSLTKEAMPVI 306 Query: 537 WKNHDRYLDTYLNPYPGYYFTGDGAAKDKDGYIWILGRVDDVVNVSGHRLSTAEIEAAII 596 I GR DD++ V G + ++IE ++ Sbjct: 307 RYRTRDLTALLPPTARAMRRLA-----------KITGRSDDMLIVRGVNVFPSQIEEIVV 355 Query: 597 EDPIVAECAVVGFNDDLTGQAVAAFVVLKNKSSWSTATDDELQDIKKHLVFTVRKDIGPF 656 P+++ + + D + V L+++++ S TD E + + L ++ + Sbjct: 356 ALPLLSGQFQITLSRDGHMDRLDLAVELRSEAAAS-VTDGERAALARELQHRIKT-MVGV 413 Query: 657 AAPKLIILVDDLPKTRSGKIMRRILRKILA 686 ++ ++ +P T +GK R I R+ A Sbjct: 414 SSGVTVLAAGGIPATATGKARRVIDRRQAA 443 >2Y4N-A nrPDB Length = 437 Score = 90.8 bits (223), Expect = 2e-18, Method: Composition-based stats. Identities = 71/386 (18%), Positives = 127/386 (32%), Gaps = 30/386 (7%) Query: 301 KTYYPCTPVDSEDPLFLLYTSGSTGAPKGVQHSTAGYLLGALLTMRY--TFDTHQEDVFF 358 + V + + +SG+TG P V ++ A A L R + D Sbjct: 79 SYPFGMFAVPQDRISRIHASSGTTGKPTVVGYTAADIDTWANLVARSIRAAGARRGDKVH 138 Query: 359 TAGDIGWITGHTYVVYGPLLYGCATLVFEGTPAYPNYSRYWDIIDEHKVTQFYVAPTALR 418 + G TG YG G + F G + +I + + V P+ + Sbjct: 139 VSYGYGLFTGGLGAHYGAERAGLTVIPFGG----GQTEKQVQLIQDFRPDIIMVTPSYML 194 Query: 419 LLKRAGDSYIENHSLKSLRCLGSVGEPIAAEVWEWYSEKIGKNEIPIVDTYWQTESGSHL 478 + + + SLR EP ++ +++G I VD Y +E Sbjct: 195 SIADEIERQGLDPVQSSLRIGIFGAEPWTNDMRVAIEQRMG---IDAVDIYGLSEVMGPG 251 Query: 479 VTPLAGGVTPMKPGSASFPFFGIDAVVLDPNTGEELNTSHAEGVLAVKAAWPSFARTIWK 538 V A K G + ++DP TGE L ++ + ++ Sbjct: 252 V---ASECVETKDGPTIWEDHFY-PEIIDPETGEVLPDGELGELVFTSLTKEALPIIRYR 307 Query: 539 NHDRYLDTYLNPYPGYYFTGDGAAKDKDGYIWILGRVDDVVNVSGHRLSTAEIEAAIIED 598 D PG T +K I GR DD++ V G + +IE +++ Sbjct: 308 TRDLTR-----LLPGTART--MRRMEK-----ITGRSDDMMIVRGVNVFPTQIEEQLLK- 354 Query: 599 PIVAECAVVGFNDDLTGQAVAAFVVLKNKSSWSTATDDELQDIKKHLVFTVRKDIGPFAA 658 + LT + + L + TA D + K + K + A Sbjct: 355 ---QRALAPHYQIVLTKEGPLDVLTLNVEPCPETAPDTAAIQVAKQALAYDIKSLIGVTA 411 Query: 659 PKLIILVDDLPKTRSGKIMRRILRKI 684 ++ V+ + + GK R + ++ Sbjct: 412 VINVLPVNGIER-SVGKARRVVDKRK 436 >6HIV-BC nrPDB Length = 523 Score = 59.2 bits (141), Expect = 5e-09, Method: Composition-based stats. Identities = 72/451 (15%), Positives = 144/451 (31%), Gaps = 52/451 (11%) Query: 159 GQGYSITYKELLEEVCQVAQVLTYSMGVRKGDTVAVYMPMVPEAIITLLAISRIGAIHSV 218 Q + ++ + +A L + G+R G V P E + LA ++IGA+ +V Sbjct: 85 HQAVRWAFADIRKNSEALAHGLLQT-GLRPGQRVLAIQPCNCETFVLQLACAKIGALLAV 143 Query: 219 VF-AGFSSNSLRDRINDGDSKVVIT--------TDESNRGGKVIETKRIVDDALRETPG- 268 V S++ LR +N+ +I + + + ++ + + E Sbjct: 144 VPHHNISADKLRFYLNEFQPHHLIAREWIVVPEVKQGVLVERNMHFWDMIYNVIPELGLS 203 Query: 269 ----------------VRHVLVYRKTNNPSVAFHAPRDLDWATEK-KKYKTYYPCTPVDS 311 ++ V++ N + L W + + + Sbjct: 204 YPGQRFQWVHSQEFFFLKKVVITDHNMNLLGVTPMRKMLVWGPFSYYEQRLRRLSALLHP 263 Query: 312 EDPLFLLYTSGSTGAPKGVQHSTAGYLLGALLTMRYTFDTHQEDVFFTAGDIGWITGHTY 371 +DP+ L K + + A E F + Sbjct: 264 DDPILALEDPHPALEDKLHITYSHRNCINAGFLFGNLMGLKAESR-FGVMPNHHVDPVGA 322 Query: 372 VV--YGPLLYGCATLVF--EGTPAYPNYSRYWDIIDEHKVTQFYVAPTALRLLKRAGDSY 427 +V Y L G + + + + E V LL+ AG+ Sbjct: 323 IVAPYAALTTGAVLVHIHSDMFTDDHAINGIEKLCVEEVVGMLGKKSDFDLLLRHAGNFD 382 Query: 428 IENHS-LKSLRCLGSVGEP-IAAEVWEWYSEKIGKNEIPIVDTYWQTESGSHLV-TPLAG 484 + + LK + EP + E + ++++G ++ + ES ++ L Sbjct: 383 ADQYEHLKWVVLFEDASEPTVGDEYLQKLAKELGLEDVFVFR--GPLESAYMVMWRSLKR 440 Query: 485 GVTPMKPGSASFPFFGIDAVVL-DPNTGEE-LNTSHAEGVLAVKAAWPSFARTIWKNHDR 542 M P ++A V+ D T + + ++ G L +K P + + N Sbjct: 441 ARWEMVP--------HVEAKVVGDRGTADARILAANTRGNLKLKG--PHISAGYYNN--A 488 Query: 543 YLDTYLNPYPGYYFTGDGAAKDKDGYIWILG 573 L T L G+ T A D+ G + + G Sbjct: 489 GLLTELVDERGFCSTSREAVMDERGQLTLHG 519 >5YV5-A nrPDB Length = 536 Score = 36.1 bits (81), Expect = 0.058, Method: Composition-based stats. Identities = 23/124 (18%), Positives = 42/124 (33%), Gaps = 13/124 (10%) Query: 594 AIIEDPIVAECAVVGFNDDLTGQAVAAFVVLKNKSSWSTATDDELQD------IKKHLVF 647 + P+V E VVG A +L + + D++ D L Sbjct: 35 VLYRLPVVKEGMVVGIVGPNGTGKSTAVKILAGQLIPNLCGDNDSWDGVIRAFRGNELQN 94 Query: 648 TVRKDIGPFAAP-KLIILVDDLPKTRSGKIMRRILRKILAGESDQLGDVSTLSNPGIVRH 706 K P VD +PK GK++ L ++D+ G + + + + Sbjct: 95 YFEKLKNGEIRPVVKPQYVDLIPKAVKGKVIE------LLKKADETGKLEEVVKALELEN 148 Query: 707 LIDS 710 ++D Sbjct: 149 VLDR 152 >5YHV-A nrPDB Length = 394 Score = 36.1 bits (81), Expect = 0.059, Method: Composition-based stats. Identities = 13/121 (10%), Positives = 29/121 (23%), Gaps = 5/121 (4%) Query: 174 CQVAQVLTYSMGVRKG-DTVAVYMPMVPEAIITLLAISRIGAIHSVVFAGFSSNSLRDRI 232 +A G+ D V + ++ LA G ++ G+ Sbjct: 81 DAIAADYQRRHGITVEPDAVVITTGSSGGFLLAFLACFDAGDRVAMASPGYPCYRNILSA 140 Query: 233 NDGDSKVVITTDESNRGGKVIETKRIVDDALRETPGVRHVLVYRKTNNPSVAFHAPRDLD 292 + + ++ T +++ + GV T Sbjct: 141 LGCEVVEIPCGPQTRFQ----PTAQMLAEIDPPLRGVVVASPANPTGTVIPPEELAAIAS 196 Query: 293 W 293 W Sbjct: 197 W 197 >2YWB-A nrPDB Length = 503 Score = 33.4 bits (74), Expect = 0.41, Method: Composition-based stats. Identities = 30/263 (11%), Positives = 75/263 (28%), Gaps = 39/263 (14%) Query: 59 QPAIATHYSPHLDGLQDYQRL---HKESIEDPAKFFGSKATQFLNWSKPFDKVFIPDPKT 115 + + H P GL+ ++ H++++ P + A N P + PD + Sbjct: 102 KALLTRHEGPLFRGLEGEVQVWMSHQDAVTAPPPGWRVVAETEEN---PVAAIASPDGRA 158 Query: 116 GRPSF-QNNAWFLNGQLNACYNCVDRHALKTPNKKAIIFEGDEPGQGYSITYKELLEEVC 174 F A G + N ++ +K + + + +E+ E Sbjct: 159 YGVQFHPEVAHTPKG-MQILENFLELAGVKRD------WTPEHVLEELL---REVRERAG 208 Query: 175 QVAQVLTYSMGVRKGDTVAVYMPMVPEAIITLLAISRIGAIHSVVFAGFSS------NSL 228 + D V + + ++ L +++ G H VF + Sbjct: 209 K--------------DRVLLAVSGGVDSSTLALLLAKAGVDHLAVFVDHGLLRLGEREEV 254 Query: 229 RDRINDGDSKVVITTDESNRGGKVIETKRIVDDALRETPGVRHVLVYRKTNNPSVAFHAP 288 + +++ + + + + R+ G V + + F Sbjct: 255 EGALRALGVNLLVVDAKERFLKALKGVED--PEEKRKIIGREFVAAFSQVARERGPFRFL 312 Query: 289 RDLDWATEKKKYKTYYPCTPVDS 311 + + + + S Sbjct: 313 AQGTLYPDVIESAGGHGAAKIKS 335 >1RPZ-A nrPDB Length = 301 Score = 32.6 bits (72), Expect = 0.65, Method: Composition-based stats. Identities = 30/188 (15%), Positives = 53/188 (28%), Gaps = 20/188 (10%) Query: 254 ETKRIVDDALRETPGVRHVLVYRKTNNPSVAFHAPRDLDWATEKKKYKTYYPCTPVDSED 313 K ++ P R H D+ W K+ T D Sbjct: 77 SVKGVIISDTNLNPERRLAWETFAKEYGWKVEHKVFDVPWTELVKRNS--KRGTKAVPID 134 Query: 314 PLFLLYTS-----------GSTGAPKGVQHSTAGYLLGALLTMRYTFDTHQEDVFFTAGD 362 L +Y S G+ G PK V G L Y + DV Sbjct: 135 VLRSMYKSMREYLGLPVYNGTPGKPKAVIFDVDGTLAKMNGRGPYDLEKCDTDVI---NP 191 Query: 363 IGWITGHTYVVYGPLLYGCATLVFEGTPAYPNYSRYWDIIDEHKVTQFYVAPTALRLLKR 422 + Y + G Y + + + ++Y+ + + V P ++ + Sbjct: 192 MVVELSKMYALMG---YQIVVVSGRESGTKEDPTKYYRMTRKW-VEDIAGVPLVMQCQRE 247 Query: 423 AGDSYIEN 430 GD+ ++ Sbjct: 248 QGDTRKDD 255 >3J15-B nrPDB Length = 593 Score = 32.2 bits (71), Expect = 0.78, Method: Composition-based stats. Identities = 19/98 (19%), Positives = 39/98 (39%), Gaps = 8/98 (8%) Query: 594 AIIEDPIVAECAVVGFNDDLTGQAVAAFVVLKNKSSWSTATDDE-----LQDIKKHLVFT 648 + PIV + VVG A +L + + D++ ++ + + + Sbjct: 93 VLYRLPIVKDGMVVGIVGPNGTGKTTAVKILAGQLIPNLCEDNDSWDNVIRAFRGNELQN 152 Query: 649 VRKDIGPFAAPKLII--LVDDLPKTRSGKIMRRILRKI 684 + + ++ VD LPK GK+ R +L+K+ Sbjct: 153 YFERLKNGEIRPVVKPQYVDLLPKAVKGKV-RELLKKV 189 >3KGX-A nrPDB Length = 393 Score = 32.2 bits (71), Expect = 0.89, Method: Composition-based stats. Identities = 17/88 (19%), Positives = 29/88 (32%), Gaps = 9/88 (10%) Query: 523 LAVKAAWPSFARTIWKNHDRYLDTYLNPYPGYY--FTGDGAAKDKDGYIWILGRVDDVVN 580 L V + T N D++L G + + A + I RV ++ Sbjct: 77 LVVSGSGHCAMETALFNLLEPGDSFLTGTNGIWGMRAAEIADR-------IGARVHQMIK 129 Query: 581 VSGHRLSTAEIEAAIIEDPIVAECAVVG 608 G + E+E + + V V G Sbjct: 130 KPGEHYTLQEVEEGLAQHKPVLLFLVHG 157 >3WO8-A nrPDB Length = 478 Score = 31.8 bits (70), Expect = 1.1, Method: Composition-based stats. Identities = 17/85 (20%), Positives = 35/85 (41%), Gaps = 5/85 (5%) Query: 627 KSSWSTATDDELQDIKKHLVFTVRKDIGPFAAPKLIILVDDLPKTRSGKIMRRILRKILA 686 + + +++L +K L + + +D LP T S KI+ +LR+ + Sbjct: 191 DAPFEKLWEEDLLPFRKVLEREKKVTVMTAHV--RYSSIDSLPATLSEKIITDVLREKIG 248 Query: 687 GESDQLGDV---STLSNPGIVRHLI 708 + + D S +SN V ++ Sbjct: 249 FDGLVISDAMEMSAVSNNFSVEEIV 273 >3WBH-A nrPDB Length = 527 Score = 31.4 bits (69), Expect = 1.3, Method: Composition-based stats. Identities = 18/106 (16%), Positives = 35/106 (33%), Gaps = 7/106 (6%) Query: 128 NGQLNACYNCVDRHALKTPNK------KAIIFEGDEPGQGYSITYKELLEEVCQVAQVLT 181 +G ++ +A + P+ A E G+S+T+ E V Sbjct: 41 DGMGPQQVGLLETYANQAPDSIYDGEPTAFHQLAKEGVVGFSLTHPEDAVVVDSACSATQ 100 Query: 182 YSMGVRKG-DTVAVYMPMVPEAIITLLAISRIGAIHSVVFAGFSSN 226 + G+ G + + + P + LA +R A V + Sbjct: 101 LASGIYSGSEVIGIDAEGNPVETVLELAQARGKATGLVSDTRLTHA 146 >2I2W-A nrPDB Length = 212 Score = 31.4 bits (69), Expect = 1.4, Method: Composition-based stats. Identities = 14/70 (20%), Positives = 22/70 (31%), Gaps = 3/70 (4%) Query: 168 ELLEEVCQVAQVLTYSMGVRKGDTVAVYMPMVPEAIITLLAISRIGAIHSVVFAGFSSNS 227 EL E +A L + AV + +A +L+ G S A + Sbjct: 29 ELNEAAETLANFLKDDANIHAIQRAAVLLADSFKAGGKVLSC---GNGGSHCDAMHFAEE 85 Query: 228 LRDRINDGDS 237 L R + Sbjct: 86 LTGRYRENRP 95 >3L44-A nrPDB Length = 434 Score = 31.0 bits (68), Expect = 1.6, Method: Composition-based stats. Identities = 24/100 (24%), Positives = 34/100 (34%), Gaps = 2/100 (2%) Query: 409 QFYVAPTALRLLKRAGDSYIENHSLKSLRCLGSVGEPIAAEVWEWYSEKIGKNEIPIVDT 468 Y PTAL + K A +L +R + S E + G+ +I Sbjct: 88 VLYGTPTALEV-KFAKMLKEAMPALDKVRFVNSGTEAVMT-TIRVARAYTGRTKIMKFAG 145 Query: 469 YWQTESGSHLVTPLAGGVTPMKPGSASFPFFGIDAVVLDP 508 + S LV +G T P SA P V+ P Sbjct: 146 CYHGHSDLVLVAAGSGPSTLGTPDSAGVPQSIAQEVITVP 185 >4GAX-A nrPDB Length = 563 Score = 31.0 bits (68), Expect = 1.8, Method: Composition-based stats. Identities = 18/100 (18%), Positives = 32/100 (32%), Gaps = 16/100 (16%) Query: 77 QRLHKESIEDPAKFFGSKATQFLNWSKPFDKVFIPDPKTGRPSFQNNAWFLNGQLNACYN 136 Q LH+E + +K++ + FD V P + + W L + Y+ Sbjct: 252 QSLHREELSQLSKWWKA-----------FD-VKNNAPYSRDRIVECYFWALASRFEPQYS 299 Query: 137 CVDRHALKTPNKKAIIFEGDEPGQGYSITYKELLEEVCQV 176 A K + + TY+EL + Sbjct: 300 ----RARIFLAKVIALVTLIDDIYDAYGTYEELKIFTEAI 335 >2EG4-A nrPDB Length = 230 Score = 31.0 bits (68), Expect = 1.8, Method: Composition-based stats. Identities = 7/37 (18%), Positives = 15/37 (40%) Query: 178 QVLTYSMGVRKGDTVAVYMPMVPEAIITLLAISRIGA 214 + L +G++ G V VY + + + +G Sbjct: 173 EGLLERLGLQPGQEVGVYCHSGARSAVAFFVLRSLGV 209 >5BV0-A nrPDB Length = 669 Score = 31.0 bits (68), Expect = 1.9, Method: Composition-based stats. Identities = 21/86 (24%), Positives = 33/86 (38%), Gaps = 8/86 (9%) Query: 73 LQDYQRLHKESIEDPAKFFGSKATQFLNWSKPFDKVFIPDPKTGRPSFQNNAWFLNGQLN 132 LQ Y H ++ + + FL+ S P + +G P + N +L QL Sbjct: 448 LQGYGHQHLLTLHNL-----ERLQMFLSKSSPLASMITMSGSSGGPDQKTNYTYLRKQLR 502 Query: 133 ACYNCVDRHALKTPNKKAIIFEGDEP 158 VD + PN A ++ G P Sbjct: 503 L---IVDEVNEQDPNDIAYVYSGYAP 525 >5LHE-A nrPDB Length = 207 Score = 30.3 bits (66), Expect = 2.9, Method: Composition-based stats. Identities = 21/124 (16%), Positives = 41/124 (33%), Gaps = 14/124 (11%) Query: 584 HRLSTAEIEAAIIEDPIVAECAVVGFNDDLTGQAVAAFVVLKNKSSWSTATDDELQDIKK 643 + I+ P AV D+ + AF+V + + + L+ I + Sbjct: 70 EKTGAEYIQVHSDMHPK----AVNRLKDEYGVSVMKAFMVPRESDDPAEDAERLLELIGQ 125 Query: 644 HLVFTVRKDIGPFAAPKLIILVDDLPKTRSGKIMRRILRKILAG--ESDQLGDVSTLSNP 701 + V + D G + + V I+ + +LAG + +G+ P Sbjct: 126 YEVDKILLDTGVGSGRRHDYRVSA--------IIAKEYPIVLAGGLTPENVGEAIRWVKP 177 Query: 702 GIVR 705 V Sbjct: 178 AGVD 181 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.304 0.113 0.267 Lambda K H 0.267 0.0349 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 23,147,463 Number of Sequences: 36641 Number of extensions: 929960 Number of successful extensions: 2890 Number of sequences better than 10.0: 64 Number of HSP's better than 10.0 without gapping: 92 Number of HSP's successfully gapped in prelim test: 23 Number of HSP's that attempted gapping in prelim test: 2417 Number of HSP's gapped (non-prelim): 158 length of query: 713 length of database: 10,336,785 effective HSP length: 104 effective length of query: 609 effective length of database: 6,526,121 effective search space: 3974407689 effective search space used: 3974407689 T: 11 A: 40 X1: 16 ( 7.0 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.1 bits) S2: 62 (28.7 bits)