BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q00535 (292 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 4AU8-A nrPDB 602 e-173 1V0B-A nrPDB 360 e-100 2BPM-A nrPDB 357 3e-99 5G6V-A nrPDB 344 2e-95 3NIZ-A nrPDB 340 4e-94 6GU6-A nrPDB 337 5e-93 4KRC-A nrPDB 332 1e-91 3GC0-A nrPDB 304 4e-83 1UA2-A nrPDB 265 2e-71 1G3N-A nrPDB 243 5e-65 2W96-B nrPDB 237 4e-63 4NST-A nrPDB 226 1e-59 5EFQ-A nrPDB 225 2e-59 4AGU-A nrPDB 225 2e-59 4BBM-A nrPDB 219 1e-57 4BGQ-A nrPDB 218 2e-57 3MIA-A nrPDB 217 4e-57 3ZDU-A nrPDB 194 3e-50 6DTL-A nrPDB 192 1e-49 4QTB-A nrPDB 189 2e-48 2F9G-A nrPDB 188 2e-48 4ZSG-A nrPDB 186 1e-47 5Z33-A nrPDB 186 2e-47 4IC8-A nrPDB 185 2e-47 4CRL-A nrPDB 184 3e-47 3OZ6-A nrPDB 180 6e-46 5NGU-A nrPDB 177 4e-45 3GC9-A nrPDB 176 2e-44 4MYG-A nrPDB 175 2e-44 3N9X-A nrPDB 174 3e-44 4E7W-A nrPDB 172 1e-43 4EWQ-A nrPDB 172 1e-43 1CM8-A nrPDB 172 2e-43 4O2Z-A nrPDB 171 4e-43 3NIE-A nrPDB 171 4e-43 3OHT-A nrPDB 171 4e-43 2I6L-A nrPDB 167 4e-42 3RP9-A nrPDB 160 6e-40 5AIR-A nrPDB 160 6e-40 1JNK-A nrPDB 160 9e-40 3FI2-A nrPDB 159 1e-39 2XS0-A nrPDB 157 5e-39 4QNY-A nrPDB 156 1e-38 3E7O-A nrPDB 154 4e-38 3E3P-A nrPDB 152 1e-37 3EB0-A nrPDB 152 2e-37 5AWM-A nrPDB 147 4e-36 3PG1-A nrPDB 145 3e-35 6HMD-A nrPDB 133 9e-32 5ZTN-A nrPDB 129 1e-30 4UZD-A nrPDB 129 1e-30 3D2K-A nrPDB 127 4e-30 6O6Q-A nrPDB 127 6e-30 4MVF-A nrPDB 126 9e-30 2PVN-A nrPDB 126 1e-29 4LFI-A nrPDB 124 7e-29 6CQF-A nrPDB 123 1e-28 5XVU-A nrPDB 122 2e-28 6EII-A nrPDB 120 7e-28 4MD7-E nrPDB 119 1e-27 4CZT-A nrPDB 119 1e-27 4B8L-A nrPDB 119 2e-27 5Y86-A nrPDB 119 2e-27 3LIJ-A nrPDB 118 2e-27 3DFA-A nrPDB 116 1e-26 3NCG-A nrPDB 115 2e-26 6FDY-U nrPDB 114 4e-26 3DXN-A nrPDB 114 6e-26 3HZT-A nrPDB 112 2e-25 4D28-A nrPDB 112 2e-25 4APC-A nrPDB 111 3e-25 5YKS-A nrPDB 110 5e-25 5J5T-A nrPDB 109 1e-24 4JXF-A nrPDB 108 3e-24 3COM-A nrPDB 108 3e-24 4RGJ-A nrPDB 107 6e-24 4LG4-A nrPDB 107 8e-24 6AO5-A nrPDB 106 1e-23 2WO6-A nrPDB 106 1e-23 2WQN-A nrPDB 106 1e-23 5WAX-A nrPDB 105 2e-23 3MA6-A nrPDB 105 2e-23 5JN2-A nrPDB 104 3e-23 4YNZ-A nrPDB 104 4e-23 4AF3-A nrPDB 104 5e-23 5ES1-A nrPDB 104 6e-23 3MN3-A nrPDB 103 8e-23 5XZW-A nrPDB 103 9e-23 3H4J-B nrPDB 103 9e-23 2WTK-C nrPDB 102 1e-22 3Q5I-A nrPDB 102 1e-22 6QAU-A nrPDB 102 1e-22 4FG9-A nrPDB 101 3e-22 6HXF-B nrPDB 101 4e-22 4CQG-A nrPDB 100 5e-22 2XNP-A nrPDB 100 6e-22 5IG1-A nrPDB 100 7e-22 2BRG-A nrPDB 100 7e-22 3TAC-A nrPDB 100 1e-21 3HKO-A nrPDB 100 1e-21 3UDB-A nrPDB 100 1e-21 2QNJ-A nrPDB 100 1e-21 3F3Z-A nrPDB 100 1e-21 4IAN-A nrPDB 100 1e-21 6FD3-A nrPDB 100 1e-21 4PDS-A nrPDB 99 2e-21 4B6L-A nrPDB 99 2e-21 5KZ7-A nrPDB 98 3e-21 2Q0N-A nrPDB 98 5e-21 4JDH-A nrPDB 98 5e-21 4RED-A nrPDB 97 6e-21 4KS7-A nrPDB 97 6e-21 3UTO-A nrPDB 97 6e-21 4XBR-A nrPDB 97 7e-21 1KOA-A nrPDB 97 7e-21 4FIE-A nrPDB 97 9e-21 6GVJ-A nrPDB 97 9e-21 4REW-A nrPDB 97 9e-21 3ZUT-A nrPDB 96 1e-20 2HAK-A nrPDB 96 2e-20 4CFH-A nrPDB 96 2e-20 3HMP-A nrPDB 96 2e-20 3Q53-A nrPDB 96 2e-20 2VN9-A nrPDB 96 2e-20 6C9D-A nrPDB 96 2e-20 5AP3-A nrPDB 96 2e-20 4QMW-A nrPDB 96 2e-20 4WNO-A nrPDB 96 3e-20 2F57-A nrPDB 95 4e-20 4KIK-B nrPDB 95 4e-20 5D7A-A nrPDB 94 5e-20 4D2V-A nrPDB 94 8e-20 2ZMD-A nrPDB 94 9e-20 4CSV-A nrPDB 94 9e-20 2UV2-A nrPDB 94 1e-19 1U5R-A nrPDB 93 2e-19 5U6Y-A nrPDB 93 2e-19 5FG8-A nrPDB 93 2e-19 2VZ6-A nrPDB 92 2e-19 2GCD-A nrPDB 92 2e-19 6E2O-A nrPDB 92 2e-19 2JC6-A nrPDB 92 3e-19 2Y7J-A nrPDB 91 4e-19 3GUB-A nrPDB 91 4e-19 5D9K-A nrPDB 91 5e-19 3SOA-A nrPDB 91 5e-19 5KKR-C nrPDB 91 8e-19 3BHH-A nrPDB 90 9e-19 3UC3-A nrPDB 90 1e-18 1TKI-A nrPDB 90 1e-18 4RLP-A nrPDB 90 1e-18 3EQC-A nrPDB 90 1e-18 4EQM-A nrPDB 90 1e-18 4L42-A nrPDB 90 1e-18 2J90-A nrPDB 89 2e-18 4AN9-A nrPDB 89 2e-18 5F9E-A nrPDB 89 2e-18 3QA8-A nrPDB 89 3e-18 2X4F-A nrPDB 89 3e-18 2W4O-A nrPDB 88 4e-18 2JAM-A nrPDB 88 4e-18 2XIK-A nrPDB 88 5e-18 2Z7Q-A nrPDB 88 5e-18 1S9I-A nrPDB 88 5e-18 5JZN-A nrPDB 87 6e-18 2V7O-A nrPDB 87 6e-18 6NPU-A nrPDB 87 7e-18 1ZXE-A nrPDB 87 7e-18 3IS5-A nrPDB 87 7e-18 3KK8-A nrPDB 87 8e-18 4U41-A nrPDB 87 9e-18 4XEY-B nrPDB 87 1e-17 4FZF-B nrPDB 87 1e-17 3RAW-A nrPDB 87 1e-17 2BDW-A nrPDB 87 1e-17 5DBX-A nrPDB 86 2e-17 1AD5-A nrPDB 86 2e-17 3VN9-A nrPDB 86 2e-17 2A27-A nrPDB 86 2e-17 2XYN-A nrPDB 86 2e-17 1ZWS-A nrPDB 86 2e-17 6F3F-A nrPDB 86 2e-17 2PL0-A nrPDB 86 2e-17 2H8H-A nrPDB 86 3e-17 5HVK-A nrPDB 85 3e-17 2A1A-B nrPDB 85 3e-17 4CFF-A nrPDB 85 3e-17 5SYS-A nrPDB 85 3e-17 4RA4-A nrPDB 85 4e-17 2HK5-A nrPDB 85 4e-17 2FO0-A nrPDB 85 4e-17 5EZV-A nrPDB 85 5e-17 3FME-A nrPDB 85 5e-17 2YAB-A nrPDB 84 6e-17 3ORZ-A nrPDB 84 6e-17 6CMJ-A nrPDB 84 6e-17 3UIU-A nrPDB 84 6e-17 4I6B-A nrPDB 84 8e-17 3LM0-A nrPDB 84 9e-17 2YZA-A nrPDB 84 1e-16 4YZB-A nrPDB 83 1e-16 3CJF-A nrPDB 83 1e-16 5UNP-A nrPDB 83 2e-16 3A8W-A nrPDB 83 2e-16 5DYK-A nrPDB 83 2e-16 4E93-A nrPDB 82 3e-16 5VD3-A nrPDB 82 3e-16 3PPZ-A nrPDB 82 3e-16 6CTH-A nrPDB 82 4e-16 4F9B-A nrPDB 82 4e-16 1NY3-A nrPDB 81 4e-16 4NIF-A nrPDB 81 5e-16 3DLS-A nrPDB 81 6e-16 2OZA-A nrPDB 81 6e-16 2YCR-A nrPDB 80 7e-16 1KOB-A nrPDB 80 8e-16 3ORP-A nrPDB 80 8e-16 6DBN-A nrPDB 80 1e-15 3KA0-A nrPDB 80 1e-15 2PSQ-A nrPDB 80 1e-15 5TQX-A nrPDB 80 1e-15 2W1I-A nrPDB 80 1e-15 5TUR-A nrPDB 80 2e-15 4M7I-A nrPDB 79 2e-15 4J52-A nrPDB 79 2e-15 3I6U-A nrPDB 79 2e-15 3DAK-A nrPDB 79 2e-15 5X8I-B nrPDB 79 2e-15 2DQ7-X nrPDB 79 2e-15 2OU7-A nrPDB 79 2e-15 3A4O-X nrPDB 79 2e-15 4RC3-A nrPDB 79 2e-15 3IO7-A nrPDB 79 2e-15 3BGP-A nrPDB 79 2e-15 5EG3-A nrPDB 79 2e-15 3DB8-A nrPDB 79 2e-15 3TXO-A nrPDB 79 2e-15 4JG6-A nrPDB 79 3e-15 5YV8-A nrPDB 79 3e-15 4UYA-A nrPDB 79 3e-15 5FET-A nrPDB 78 4e-15 3HDN-A nrPDB 78 5e-15 1PHK-A nrPDB 78 5e-15 6CCF-A nrPDB 78 5e-15 3TT0-A nrPDB 78 6e-15 3FXW-A nrPDB 78 6e-15 1FOT-A nrPDB 77 7e-15 5MJB-A nrPDB 77 9e-15 4XCU-A nrPDB 77 9e-15 1VZO-A nrPDB 77 9e-15 2JDO-A nrPDB 77 1e-14 5UUU-A nrPDB 77 1e-14 1LUF-A nrPDB 77 1e-14 3GQL-A nrPDB 77 1e-14 4FR4-A nrPDB 76 1e-14 5A46-A nrPDB 76 1e-14 3PVW-A nrPDB 76 2e-14 3ALO-A nrPDB 76 2e-14 5H2U-A nrPDB 76 2e-14 5O2B-A nrPDB 76 2e-14 2RIO-A nrPDB 75 2e-14 4UY9-A nrPDB 75 2e-14 3DTC-A nrPDB 75 3e-14 4PL5-B nrPDB 75 3e-14 6FYV-A nrPDB 75 3e-14 5O2C-A nrPDB 75 3e-14 5AMN-A nrPDB 75 3e-14 3OMV-A nrPDB 75 4e-14 4TPT-A nrPDB 75 5e-14 6GQK-A nrPDB 75 5e-14 6HV0-A nrPDB 75 5e-14 2I0E-A nrPDB 74 5e-14 2X7G-A nrPDB 74 5e-14 3KN6-A nrPDB 74 8e-14 3MV5-A nrPDB 74 8e-14 3PFQ-A nrPDB 74 8e-14 4PDO-A nrPDB 74 9e-14 4AT3-A nrPDB 74 1e-13 5O0Y-A nrPDB 74 1e-13 3ZZW-A nrPDB 74 1e-13 5KCV-A nrPDB 74 1e-13 2JD5-A nrPDB 73 1e-13 3QGY-A nrPDB 73 1e-13 6ED6-A nrPDB 73 2e-13 5LOH-A nrPDB 73 2e-13 4TNB-A nrPDB 72 2e-13 4OLI-A nrPDB 72 2e-13 3VHK-A nrPDB 72 2e-13 6E9W-A nrPDB 72 3e-13 2PMN-X nrPDB 72 3e-13 5N23-A nrPDB 72 3e-13 4HVI-A nrPDB 72 4e-13 4EBW-A nrPDB 72 4e-13 4PWN-A nrPDB 72 4e-13 4AW2-A nrPDB 71 4e-13 5VO2-A nrPDB 71 5e-13 6BDL-A nrPDB 71 5e-13 3HNG-A nrPDB 71 5e-13 4WB7-A nrPDB 71 6e-13 6DBM-A nrPDB 71 6e-13 6FER-A nrPDB 71 6e-13 4K33-A nrPDB 71 7e-13 5FM2-A nrPDB 70 7e-13 5B2L-A nrPDB 70 9e-13 4XI2-A nrPDB 70 1e-12 3V5Q-A nrPDB 70 1e-12 4C0T-A nrPDB 70 1e-12 4E20-A nrPDB 70 2e-12 2Y4I-B nrPDB 70 2e-12 6FEX-A nrPDB 69 2e-12 5L6P-A nrPDB 69 2e-12 3G0E-A nrPDB 69 2e-12 2VWV-A nrPDB 69 2e-12 4WUA-A nrPDB 69 2e-12 5X3F-B nrPDB 69 3e-12 4C59-A nrPDB 69 3e-12 5HI2-A nrPDB 69 3e-12 3C1X-A nrPDB 68 4e-12 2J0K-A nrPDB 68 4e-12 3M42-A nrPDB 68 4e-12 4H1J-A nrPDB 68 5e-12 4XUF-A nrPDB 68 5e-12 1U59-A nrPDB 68 5e-12 6E4F-A nrPDB 68 5e-12 5X02-A nrPDB 68 5e-12 3LZB-A nrPDB 68 5e-12 5IKW-A nrPDB 67 7e-12 5GNK-A nrPDB 67 7e-12 1K9A-A nrPDB 67 7e-12 5KMM-A nrPDB 67 7e-12 3PLS-A nrPDB 67 7e-12 3C51-A nrPDB 67 8e-12 2R2P-A nrPDB 67 8e-12 2VD5-A nrPDB 67 1e-11 1BYG-A nrPDB 67 1e-11 3SXS-A nrPDB 67 1e-11 2OZO-A nrPDB 67 1e-11 5HLW-A nrPDB 67 1e-11 4P5Q-A nrPDB 66 2e-11 3LLT-A nrPDB 66 2e-11 4XLV-A nrPDB 66 2e-11 3DKO-A nrPDB 66 2e-11 6BSD-A nrPDB 66 2e-11 5U6C-A nrPDB 65 2e-11 4X7Q-B nrPDB 65 3e-11 5TOS-A nrPDB 65 3e-11 1FVR-A nrPDB 65 3e-11 4G3E-A nrPDB 65 3e-11 6CKI-A nrPDB 65 4e-11 5GRN-A nrPDB 65 4e-11 1JPA-A nrPDB 65 4e-11 3BBT-B nrPDB 65 4e-11 3KUL-B nrPDB 65 5e-11 4JLC-A nrPDB 65 5e-11 3NYO-A nrPDB 64 5e-11 4YHJ-A nrPDB 64 5e-11 5U6B-A nrPDB 64 6e-11 4Y93-A nrPDB 64 6e-11 5X5O-A nrPDB 64 6e-11 2Y6O-A nrPDB 64 7e-11 5LPV-A nrPDB 64 7e-11 5LPZ-A nrPDB 64 7e-11 4HZS-A nrPDB 64 8e-11 1U54-B nrPDB 64 8e-11 4EUT-A nrPDB 64 1e-10 4LRM-A nrPDB 64 1e-10 6J5U-C nrPDB 63 1e-10 6O8B-A nrPDB 63 1e-10 6NT9-A nrPDB 63 1e-10 4IDT-A nrPDB 63 1e-10 3TKU-A nrPDB 63 1e-10 4EUU-A nrPDB 63 2e-10 2CMW-A nrPDB 63 2e-10 4OW8-A nrPDB 63 2e-10 5C26-A nrPDB 62 2e-10 5HIE-A nrPDB 62 2e-10 5VC6-A nrPDB 62 2e-10 3LMG-A nrPDB 62 3e-10 4X3F-A nrPDB 62 3e-10 6B2Q-A nrPDB 62 3e-10 4FL3-A nrPDB 62 3e-10 5WNO-A nrPDB 62 4e-10 2CHL-A nrPDB 62 4e-10 2OGV-A nrPDB 61 6e-10 4NEU-A nrPDB 61 6e-10 4Y83-A nrPDB 61 6e-10 4GS6-A nrPDB 61 6e-10 4F0G-A nrPDB 61 7e-10 3BEA-A nrPDB 60 9e-10 3I81-A nrPDB 60 1e-09 4RT7-A nrPDB 60 1e-09 2HW6-A nrPDB 60 2e-09 5UIU-A nrPDB 59 2e-09 2C47-A nrPDB 59 2e-09 4M66-A nrPDB 59 3e-09 6BXI-A nrPDB 58 4e-09 3KRL-A nrPDB 58 4e-09 5TE0-A nrPDB 58 5e-09 6BFN-A nrPDB 58 5e-09 5VDK-A nrPDB 58 6e-09 4R7H-A nrPDB 58 6e-09 2QKW-B nrPDB 57 1e-08 3G2F-A nrPDB 57 1e-08 3PP0-A nrPDB 56 1e-08 3QUP-A nrPDB 56 2e-08 2BUJ-A nrPDB 56 2e-08 3SV0-A nrPDB 55 3e-08 3QD2-B nrPDB 55 3e-08 5XD6-A nrPDB 55 5e-08 5FQD-C nrPDB 55 5e-08 4OTD-A nrPDB 55 5e-08 3MDY-A nrPDB 54 9e-08 4JRN-A nrPDB 54 1e-07 4CRS-A nrPDB 54 1e-07 4YFF-A nrPDB 52 2e-07 3SOC-A nrPDB 52 4e-07 5USZ-A nrPDB 52 4e-07 2H34-A nrPDB 51 7e-07 2QLU-A nrPDB 50 1e-06 5WNL-A nrPDB 50 1e-06 4BTK-A nrPDB 49 2e-06 4NFN-A nrPDB 49 2e-06 4LQP-A nrPDB 49 2e-06 5X18-A nrPDB 49 2e-06 5AR8-A nrPDB 49 2e-06 3Q4U-A nrPDB 49 2e-06 4NT4-A nrPDB 49 3e-06 4O1O-A nrPDB 48 5e-06 3UIM-A nrPDB 48 6e-06 4Y12-A nrPDB 47 1e-05 1CSN-A nrPDB 46 2e-05 2PZI-A nrPDB 45 3e-05 5M07-A nrPDB 45 3e-05 4M69-B nrPDB 45 4e-05 1PY5-A nrPDB 45 4e-05 4IX6-A nrPDB 44 6e-05 4BTF-A nrPDB 44 7e-05 4TN6-A nrPDB 44 9e-05 4L00-A nrPDB 44 9e-05 5X1R-A nrPDB 44 9e-05 4XHH-A nrPDB 44 1e-04 4XHL-A nrPDB 43 1e-04 5L2Q-C nrPDB 41 5e-04 5E8V-A nrPDB 41 6e-04 4OAU-C nrPDB 40 0.002 5UU1-A nrPDB 39 0.002 4L68-A nrPDB 38 0.005 2RSV-A nrPDB 36 0.019 2LAV-A nrPDB 36 0.022 3MY0-A nrPDB 35 0.046 6G4J-A nrPDB 34 0.057 5CLR-A nrPDB 33 0.15 5OAT-A nrPDB 32 0.33 3G1Z-A nrPDB 30 1.0 6G38-A nrPDB 30 1.3 4AZW-A nrPDB 30 1.6 4WWA-A nrPDB 30 1.7 4AZV-A nrPDB 30 1.7 6CNC-N nrPDB 29 2.0 4CYJ-A nrPDB 29 2.2 6J6I-B nrPDB 29 2.4 4CI6-B nrPDB 29 2.8 5KH2-A nrPDB 28 6.6 6EQI-C nrPDB 27 8.5 >4AU8-A nrPDB Length = 296 Score = 602 bits (1553), Expect = e-173, Method: Compositional matrix adjust. Identities = 291/291 (100%), Positives = 291/291 (100%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK Sbjct: 6 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 65 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN 121 NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN Sbjct: 66 NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN 125 Query: 122 VLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYST 181 VLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYST Sbjct: 126 VLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYST 185 Query: 182 SIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPM 241 SIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPM Sbjct: 186 SIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPM 245 Query: 242 YPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 292 YPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP Sbjct: 246 YPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 296 >1V0B-A nrPDB Length = 288 Score = 360 bits (925), Expect = e-100, Method: Compositional matrix adjust. Identities = 174/288 (60%), Positives = 215/288 (74%), Gaps = 2/288 (0%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 M+KY LEKIGEGTYG V+KA+N E ALK++RL+ +DEG+PS+ +REI +LKELKH Sbjct: 1 MEKYHGLEKIGEGTYGVVYKAQNN-YGETFALKKIRLEKEDEGIPSTTIREISILKELKH 59 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 NIV+L+DV+H+ K+L LVFE DQDLKK D C G L+ KSFL QLL G+ +CH R Sbjct: 60 SNIVKLYDVIHTKKRLVLVFEHLDQDLKKLLDVCEGGLESVTAKSFLLQLLNGIAYCHDR 119 Query: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYS 180 VLHRDLKPQNLLINR GELK+ADFGLARAFGIPVR Y+ EVVTLWYR PDVL G+K YS Sbjct: 120 RVLHRDLKPQNLLINREGELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVLMGSKKYS 179 Query: 181 TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYP 240 T+ID+WS GCIFAE+ N G PLFPG DQL RIFR+LGTP + WP++T+LP Y P Sbjct: 180 TTIDIWSVGCIFAEMVN-GAPLFPGVSEADQLMRIFRILGTPNSKNWPNVTELPKYDPNF 238 Query: 241 MYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288 + + L+ +G DLL +LK +P QRI+A++AL+H YF + Sbjct: 239 TVYEPLPWESFLKGLDESGIDLLSKMLKLDPNQRITAKQALEHAYFKE 286 >2BPM-A nrPDB Length = 309 Score = 357 bits (916), Expect = 3e-99, Method: Compositional matrix adjust. Identities = 176/294 (59%), Positives = 219/294 (74%), Gaps = 4/294 (1%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 M+ ++K+EKIGEGTYG V+KA+N+ T E+VALK++RLD + EGVPS+A+REI LLKEL H Sbjct: 6 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 65 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDP-EIVKSFLFQLLKGLGFCHS 119 NIV+L DV+H++ KL LVFEF QDLKK+ D+ P ++KS+LFQLL+GL FCHS Sbjct: 66 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 125 Query: 120 RNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLY 179 VLHRDLKPQNLLIN G +KLADFGLARAFG+PVR Y+ EVVTLWYR P++L G K Y Sbjct: 126 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 185 Query: 180 STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKP- 238 ST++D+WS GCIFAE+ R LFPG+ DQL RIFR LGTP E WP +T +PDYKP Sbjct: 186 STAVDIWSLGCIFAEMVTR-RALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPS 244 Query: 239 YPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 292 +P + A VVP L+ GR LL +L +P +RISA+ AL HP+F D P Sbjct: 245 FPKW-ARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP 297 >5G6V-A nrPDB Length = 324 Score = 344 bits (883), Expect = 2e-95, Method: Compositional matrix adjust. Identities = 167/288 (57%), Positives = 215/288 (74%), Gaps = 5/288 (1%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 M+ Y KL+K+GEGTY TV+K K++ T +VALK +RL+ + EG P +A+RE+ LLK+LKH Sbjct: 1 METYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE-EGAPCTAIREVSLLKDLKH 59 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 NIV LHD++H++K LTLVFE+ D+DLK+Y D C ++ VK FLFQLL+GL +CH + Sbjct: 60 ANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQ 119 Query: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYS 180 VLHRDLKPQNLLIN GELKLADFGLARA IP + Y EVVTLWYRPPD+L G+ YS Sbjct: 120 KVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYDNEVVTLWYRPPDILLGSTDYS 179 Query: 181 TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKP-- 238 T IDMW GCIF E+A GRPLFPG+ V++QL IFR+LGTPTEE WP + ++K Sbjct: 180 TQIDMWGVGCIFYEMAT-GRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYN 238 Query: 239 YPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286 YP Y A +L++ P+L++ G DLL LL+ RISAE+A++HP+F Sbjct: 239 YPKYRA-EALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFF 285 >3NIZ-A nrPDB Length = 311 Score = 340 bits (872), Expect = 4e-94, Method: Compositional matrix adjust. Identities = 169/292 (57%), Positives = 212/292 (72%), Gaps = 3/292 (1%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 M+KY+KLEK+GEGTYG V+KAK+ + IVALKR+RLD +DEG+PS+A+REI LLKEL H Sbjct: 20 MEKYQKLEKVGEGTYGVVYKAKDSQG-RIVALKRIRLDAEDEGIPSTAIREISLLKELHH 78 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 NIV L DV+HS++ LTLVFEF ++DLKK D L +K +L+QLL+G+ CH Sbjct: 79 PNIVSLIDVIHSERCLTLVFEFMEKDLKKVLDENKTGLQDSQIKIYLYQLLRGVAHCHQH 138 Query: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYS 180 +LHRDLKPQNLLIN +G LKLADFGLARAFGIPVR Y+ EVVTLWYR PDVL G+K YS Sbjct: 139 RILHRDLKPQNLLINSDGALKLADFGLARAFGIPVRSYTHEVVTLWYRAPDVLMGSKKYS 198 Query: 181 TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYP 240 TS+D+WS GCIFAE+ G+PLFPG DDQL +IF +LGTP +WP + +LP +K Sbjct: 199 TSVDIWSIGCIFAEMI-TGKPLFPGVTDDDQLPKIFSILGTPNPREWPQVQELPLWKQRT 257 Query: 241 MYP-ATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCP 291 +++P G DLL N+L +P +RISA +A+ HPYF D P Sbjct: 258 FQVFEKKPWSSIIPGFCQEGIDLLSNMLCFDPNKRISARDAMNHPYFKDLDP 309 >6GU6-A nrPDB Length = 302 Score = 337 bits (863), Expect = 5e-93, Method: Compositional matrix adjust. Identities = 166/292 (56%), Positives = 212/292 (72%), Gaps = 5/292 (1%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 M+ Y K+EKIGEGTYG V+K +++ T ++VA+K++RL+ ++EGVPS+A+REI LLKEL+H Sbjct: 6 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 65 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSC--NGDLDPEIVKSFLFQLLKGLGFCH 118 NIV L DVL D +L L+FEF DLKKY DS +D +VKS+L+Q+L+G+ FCH Sbjct: 66 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 125 Query: 119 SRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL 178 SR VLHRDLKPQNLLI+ G +KLADFGLARAFGIP+R Y+ EVVTLWYR P+VL G+ Sbjct: 126 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 185 Query: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYK- 237 YST +D+WS G IFAELA +PLF G+ DQL RIFR LGTP E WP + L DYK Sbjct: 186 YSTPVDIWSIGTIFAELATK-KPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN 244 Query: 238 PYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDF 289 +P + SL + V L+ G DLL +L +P +RIS + AL HPYF+D Sbjct: 245 TFPKW-KPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDL 295 >4KRC-A nrPDB Length = 317 Score = 332 bits (851), Expect = 1e-91, Method: Compositional matrix adjust. Identities = 167/297 (56%), Positives = 215/297 (72%), Gaps = 12/297 (4%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62 ++++LEK+G GTY TV+K N+ T VALK V+LD + EG PS+A+REI L+KELKH+N Sbjct: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSE-EGTPSTAIREISLMKELKHEN 64 Query: 63 IVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCN-GD----LDPEIVKSFLFQLLKGLGFC 117 IVRL+DV+H++ KLTLVFEF D DLKKY DS G+ L+ +VK F +QLL+GL FC Sbjct: 65 IVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFC 124 Query: 118 HSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAK 177 H +LHRDLKPQNLLIN+ G+LKL DFGLARAFGIPV +S+EVVTLWYR PDVL G++ Sbjct: 125 HENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSR 184 Query: 178 LYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYK 237 YSTSID+WS GCI AE+ G+PLFPG + ++QLK IF ++GTP E WPS+TKLP Y Sbjct: 185 TYSTSIDIWSCGCILAEMI-TGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYN 243 Query: 238 PYPMYPATTSLVNVV-----PKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDF 289 P L V+ L+ D L LL+ NP R+SA++AL HP+F+++ Sbjct: 244 PNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEY 300 >3GC0-A nrPDB Length = 329 Score = 304 bits (778), Expect = 4e-83, Method: Compositional matrix adjust. Identities = 151/299 (50%), Positives = 215/299 (71%), Gaps = 10/299 (3%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 + +Y ++ K+GEGTYG V+KA + T+E VA+KR+RL+ ++EGVP +A+RE+ LLKEL+H Sbjct: 33 IDRYRRITKLGEGTYGEVYKAIDTVTNETVAIKRIRLEHEEEGVPGTAIREVSLLKELQH 92 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 +NI+ L V+H + +L L+FE+ + DLKKY D N D+ ++KSFL+QL+ G+ FCHSR Sbjct: 93 RNIIELKSVIHHNHRLHLIFEYAENDLKKYMDK-NPDVSMRVIKSFLYQLINGVNFCHSR 151 Query: 121 NVLHRDLKPQNLLINRNGE-----LKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFG 175 LHRDLKPQNLL++ + LK+ DFGLARAFGIP+R ++ E++TLWYRPP++L G Sbjct: 152 RCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQFTHEIITLWYRPPEILLG 211 Query: 176 AKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPD 235 ++ YSTS+D+WS CI+AE+ PLFPG+ DQL +IF +LG P + WP +T LPD Sbjct: 212 SRHYSTSVDIWSIACIWAEML-MKTPLFPGDSEIDQLFKIFEVLGLPDDTTWPGVTALPD 270 Query: 236 YK-PYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFS--DFCP 291 +K +P + T + L+ G DLL +L+ +PV+RISA+ AL+HPYFS DF P Sbjct: 271 WKQSFPKFRGKTLKRVLGALLDDEGLDLLTAMLEMDPVKRISAKNALEHPYFSHNDFDP 329 >1UA2-A nrPDB Length = 346 Score = 265 bits (676), Expect = 2e-71, Method: Compositional matrix adjust. Identities = 133/290 (45%), Positives = 187/290 (64%), Gaps = 5/290 (1%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDE---GVPSSALREICLLKEL 58 ++YEKL+ +GEG + TV+KA+++ T++IVA+K+++L E G+ +ALREI LL+EL Sbjct: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 Query: 59 KHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCH 118 H NI+ L D ++LVF+F + DL+ + L P +K+++ L+GL + H Sbjct: 70 SHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLH 129 Query: 119 SRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL 178 +LHRDLKP NLL++ NG LKLADFGLA++FG P R Y+ +VVT WYR P++LFGA++ Sbjct: 130 QHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARM 189 Query: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKP 238 Y +DMW+ GCI AEL P PG+ DQL RIF LGTPTEEQWP M LPDY Sbjct: 190 YGVGVDMWAVGCILAELL-LRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVT 248 Query: 239 YPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288 + +P L ++ DL+Q L NP RI+A +AL+ YFS+ Sbjct: 249 FKSFPG-IPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSN 297 >1G3N-A nrPDB Length = 326 Score = 243 bits (621), Expect = 5e-65, Method: Compositional matrix adjust. Identities = 136/298 (45%), Positives = 182/298 (61%), Gaps = 15/298 (5%) Query: 2 QKYEKLEKIGEGTYGTVFKAKN-RETHEIVALKRVRLDDDDEGVPSSALREICLLKELK- 59 Q+YE + +IGEG YG VFKA++ + VALKRVR+ +EG+P S +RE+ +L+ L+ Sbjct: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 Query: 60 --HKNIVRLHDV-----LHSDKKLTLVFEFCDQDLKKYFDSC-NGDLDPEIVKSFLFQLL 111 H N+VRL DV + KLTLVFE DQDL Y D + E +K +FQLL Sbjct: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130 Query: 112 KGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPD 171 +GL F HS V+HRDLKPQN+L+ +G++KLADFGLAR + + S VVTLWYR P+ Sbjct: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSV-VVTLWYRAPE 189 Query: 172 VLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMT 231 VL + Y+T +D+WS GCIFAE+ +PLF G+ DQL +I ++G P EE WP Sbjct: 190 VLLQSS-YATPVDLWSVGCIFAEMFRR-KPLFRGSSDVDQLGKILDVIGLPGEEDWPRDV 247 Query: 232 KLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDF 289 LP + + + V ++ G+DLL L NP +RISA AL HPYF D Sbjct: 248 ALPRQAFHS--KSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDL 303 >2W96-B nrPDB Length = 306 Score = 237 bits (605), Expect = 4e-63, Method: Compositional matrix adjust. Identities = 132/294 (44%), Positives = 179/294 (60%), Gaps = 14/294 (4%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELK-- 59 +YE + +IG G YGTV+KA++ + VALK VR+ + +EG+P S +RE+ LL+ L+ Sbjct: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGLPISTVREVALLRRLEAF 63 Query: 60 -HKNIVRLHDVLHSDK-----KLTLVFEFCDQDLKKYFDSCNG-DLDPEIVKSFLFQLLK 112 H N+VRL DV + + K+TLVFE DQDL+ Y D L E +K + Q L+ Sbjct: 64 EHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLR 123 Query: 113 GLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDV 172 GL F H+ ++HRDLKP+N+L+ G +KLADFGLAR + + VVTLWYR P+V Sbjct: 124 GLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQM-ALDPVVVTLWYRAPEV 182 Query: 173 LFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTK 232 L + Y+T +DMWS GCIFAE+ +PLF GN DQL +IF L+G P E+ WP Sbjct: 183 LLQST-YATPVDMWSVGCIFAEMFRR-KPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVS 240 Query: 233 LPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286 LP P P +VVP++ +G LL +L NP +RISA ALQH Y Sbjct: 241 LPRGAFPPRGPRPVQ--SVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL 292 >4NST-A nrPDB Length = 351 Score = 226 bits (575), Expect = 1e-59, Method: Compositional matrix adjust. Identities = 123/303 (40%), Positives = 189/303 (62%), Gaps = 19/303 (6%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 + K++ + IGEGTYG V+KAK+++T E+VALK+VRLD++ EG P +A+REI +L++L H Sbjct: 12 VDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIH 71 Query: 61 KNIVRLHDVLHSDKK-----------LTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQ 109 +++V + +++ +DK+ LVFE+ D DL +S + +KSF+ Q Sbjct: 72 RSVVNMKEIV-TDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQ 130 Query: 110 LLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGI-PVRCYSAEVVTLWYR 168 L++GL +CH +N LHRD+K N+L+N +G++KLADFGLAR + R Y+ +V+TLWYR Sbjct: 131 LMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYR 190 Query: 169 PPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWP 228 PP++L G + Y+ +ID+WS GCI EL +P+F N QL+ I RL G+P WP Sbjct: 191 PPELLLGEERYTPAIDVWSCGCILGELFTK-KPIFQANLELAQLELISRLCGSPCPAVWP 249 Query: 229 SMTKLPDY---KPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPY 285 + KLP + KP Y L + + DLL ++L +P +R +AE+ LQ + Sbjct: 250 DVIKLPYFNTMKPKKQY--RRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDF 307 Query: 286 FSD 288 D Sbjct: 308 LKD 310 >5EFQ-A nrPDB Length = 347 Score = 225 bits (574), Expect = 2e-59, Method: Compositional matrix adjust. Identities = 123/306 (40%), Positives = 188/306 (61%), Gaps = 19/306 (6%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 + K++ + IGEGTYG V+KA++++T E+VALK+VRLD++ EG P +A+REI +L++L H Sbjct: 10 VDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTH 69 Query: 61 KNIVRLHDVLHSDKK-----------LTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQ 109 ++I+ + +++ +DK+ LVFE+ D DL +S + +KSF+ Q Sbjct: 70 QSIINMKEIV-TDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQ 128 Query: 110 LLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGI-PVRCYSAEVVTLWYR 168 L++GL +CH +N LHRD+K N+L+N G++KLADFGLAR + R Y+ +V+TLWYR Sbjct: 129 LMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYR 188 Query: 169 PPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWP 228 PP++L G + Y+ +ID+WS GCI EL +P+F N QL+ I R+ G+P WP Sbjct: 189 PPELLLGEERYTPAIDVWSCGCILGELFTK-KPIFQANQELAQLELISRICGSPCPAVWP 247 Query: 229 SMTKLPDY---KPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPY 285 + KLP + KP Y L + A DL +L +P +R +AE+ALQ + Sbjct: 248 DVIKLPYFNTMKPKKQY--RRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEF 305 Query: 286 FSDFCP 291 D P Sbjct: 306 LRDVEP 311 >4AGU-A nrPDB Length = 311 Score = 225 bits (573), Expect = 2e-59, Method: Compositional matrix adjust. Identities = 121/297 (40%), Positives = 172/297 (57%), Gaps = 15/297 (5%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 M+KYEK+ KIGEG+YG VFK +NR+T +IVA+K+ +DD + ALREI +LK+LKH Sbjct: 2 MEKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKH 61 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 N+V L +V ++L LVFE+CD + D + +VKS +Q L+ + FCH Sbjct: 62 PNLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFCHKH 121 Query: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYS 180 N +HRD+KP+N+LI ++ +KL DFG AR P Y EV T WYR P++L G Y Sbjct: 122 NCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYDDEVATRWYRSPELLVGDTQYG 181 Query: 181 TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLG--------TPTEEQWPSMTK 232 +D+W+ GC+FAEL +G PL+PG DQL I + LG + Q+ S K Sbjct: 182 PPVDVWAIGCVFAELL-SGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFSGVK 240 Query: 233 LPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDF 289 +PD P M P P ++ LL+ L +P +R++ E+ L HPYF + Sbjct: 241 IPD--PEDMEPLELKF----PNISYPALGLLKGCLHMDPTERLTCEQLLHHPYFENI 291 >4BBM-A nrPDB Length = 331 Score = 219 bits (557), Expect = 1e-57, Method: Compositional matrix adjust. Identities = 115/289 (39%), Positives = 165/289 (57%), Gaps = 3/289 (1%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 M+KYE L +GEG+YG V K +N++T IVA+K+ DDD+ V A+REI LLK+L+H Sbjct: 24 MEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRH 83 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 +N+V L +V K+ LVFEF D + + LD ++V+ +LFQ++ G+GFCHS Sbjct: 84 ENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIGFCHSH 143 Query: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYS 180 N++HRD+KP+N+L++++G +KL DFG AR P Y EV T WYR P++L G Y Sbjct: 144 NIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYDDEVATRWYRAPELLVGDVKYG 203 Query: 181 TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPY- 239 ++D+W+ GC+ E+ G PLFPG+ DQL I LG K P + Sbjct: 204 KAVDVWAIGCLVTEMF-MGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGVR 262 Query: 240 -PMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFS 287 P L PKL+ DL + L +P +R E L H +F Sbjct: 263 LPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQ 311 >4BGQ-A nrPDB Length = 304 Score = 218 bits (556), Expect = 2e-57, Method: Compositional matrix adjust. Identities = 120/291 (41%), Positives = 173/291 (59%), Gaps = 6/291 (2%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 M K+E L +GEG YG V K +++ETHEIVA+K+ + +++E V + LRE+ +L+ LK Sbjct: 11 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 70 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 +NIV L + KL LVFE+ ++++ + + + PE VKS+++QL+K + +CH Sbjct: 71 ENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKN 130 Query: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRC-YSAEVVTLWYRPPDVLFGAKLY 179 +++HRD+KP+NLLI+ N LKL DFG AR Y EV T WYR P++L GA Y Sbjct: 131 DIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYDEEVATRWYRSPELLLGAP-Y 189 Query: 180 STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKP- 238 S+DMWS GCI EL++ G+PLFPG DQL I ++LG EQ P + Sbjct: 190 GKSVDMWSVGCILGELSD-GQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGL 248 Query: 239 -YPMYPATTSLV-NVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFS 287 +P SL + LN+ DL++NLLK +P R E+ L HP F Sbjct: 249 RFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQ 299 >3MIA-A nrPDB Length = 351 Score = 217 bits (553), Expect = 4e-57, Method: Compositional matrix adjust. Identities = 128/310 (41%), Positives = 180/310 (58%), Gaps = 23/310 (7%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 + KYEKL KIG+GT+G VFKA++R+T + VALK+V ++++ EG P +ALREI +L+ LKH Sbjct: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75 Query: 61 KNIVRLHDVLHSDK--------KLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLK 112 +N+V L ++ + + LVF+FC+ DL + +K + LL Sbjct: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLN 135 Query: 113 GLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGI-----PVRCYSAEVVTLWY 167 GL + H +LHRD+K N+LI R+G LKLADFGLARAF + P R Y+ VVTLWY Sbjct: 136 GLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNR-YTNRVVTLWY 194 Query: 168 RPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQW 227 RPP++L G + Y ID+W AGCI AE+ P+ GN QL I +L G+ T E W Sbjct: 195 RPPELLLGERDYGPPIDLWGAGCIMAEMWTRS-PIMQGNTEQHQLALISQLCGSITPEVW 253 Query: 228 PSMTKLPDYKPYPMYPATTSLVNVVPKLNATGR-----DLLQNLLKCNPVQRISAEEALQ 282 P++ Y+ + V +L A R DL+ LL +P QRI +++AL Sbjct: 254 PNVDNYELYEKLELVKGQKR--KVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALN 311 Query: 283 HPYF-SDFCP 291 H +F SD P Sbjct: 312 HDFFWSDPMP 321 >3ZDU-A nrPDB Length = 325 Score = 194 bits (494), Expect = 3e-50, Method: Compositional matrix adjust. Identities = 107/295 (36%), Positives = 167/295 (56%), Gaps = 16/295 (5%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 M+ YE L K+GEG+YGTV K K++ T +IVA+K + + ++ V A+REI LK+ H Sbjct: 2 MEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIK-IFYERPEQSVNKIAMREIKFLKQFHH 60 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCDQ----DLKKYFDSCNGDLDPEIVKSFLFQLLKGLGF 116 +N+V L +V KK+ LVFEF D +L+ Y C+G L+ + ++ +LFQ+L+ + + Sbjct: 61 ENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHY---CHG-LESKRLRKYLFQILRAIDY 116 Query: 117 CHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGA 176 HS N++HRD+KP+N+L++++G KL DFG AR P Y EV T WYR P+++ Sbjct: 117 LHSNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYDDEVATRWYRAPELVLKD 176 Query: 177 KLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDY 236 Y +D+W+ GC+ E+A G P P + D L +I +G + +K P + Sbjct: 177 TSYGKPVDIWALGCMIIEMA-TGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIF 235 Query: 237 K----PYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFS 287 P +P PKLN D++ L+ +P RIS+ + L H YF+ Sbjct: 236 AGVVLPQVQHPKNAR--KKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYFT 288 >6DTL-A nrPDB Length = 364 Score = 192 bits (488), Expect = 1e-49, Method: Compositional matrix adjust. Identities = 113/287 (39%), Positives = 169/287 (58%), Gaps = 11/287 (3%) Query: 10 IGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDV 69 IG+G YG V A N ET+E VA+K++ D++ LREI LL+ + H+NIV + D+ Sbjct: 38 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 97 Query: 70 L-----HSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLH 124 + ++ + + +E D DL + S N L E + FL+Q+L+GL + HS NVLH Sbjct: 98 IPPPLRNAFNDVYIAYELMDTDLHQIIRS-NQALSEEHCQYFLYQILRGLKYIHSANVLH 156 Query: 125 RDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSID 184 RDLKP NLL+N N +LK+ DFGLAR + VVT WYR P++L + Y+ +ID Sbjct: 157 RDLKPSNLLLNANCDLKICDFGLARVTS-ESDFMTEYVVTRWYRAPELLLNSSDYTAAID 215 Query: 185 MWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPD--YKPYPMY 242 +WS GCIF EL + +PLFPG D QL+ + L+GTP+EE+ + + + P Y Sbjct: 216 VWSVGCIFMELMDR-KPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPY 274 Query: 243 PATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDF 289 P S+ + P ++ DL++ +L +P +RI+ +AL HPY + Sbjct: 275 P-RQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSL 320 >4QTB-A nrPDB Length = 380 Score = 189 bits (479), Expect = 2e-48, Method: Compositional matrix adjust. Identities = 110/301 (36%), Positives = 166/301 (55%), Gaps = 16/301 (5%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62 +Y +L+ IGEG YG V A + VA+K++ + + LREI +L +H+N Sbjct: 42 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLRFRHEN 100 Query: 63 IVRLHDVLHSD-----KKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFC 117 ++ + D+L + + + +V + + DL K S L + + FL+Q+L+GL + Sbjct: 101 VIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKS--QQLSNDHICYFLYQILRGLKYI 158 Query: 118 HSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSA----EVVTLWYRPPDVL 173 HS NVLHRDLKP NLLIN +LK+ DFGLAR P ++ V T WYR P+++ Sbjct: 159 HSANVLHRDLKPSNLLINTTCDLKICDFGLAR-IADPEHDHTGFLTEYVATRWYRAPEIM 217 Query: 174 FGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKL 233 +K Y+ SID+WS GCI AE+ + RP+FPG DQL I +LG+P++E + + Sbjct: 218 LNSKGYTKSIDIWSVGCILAEML-SNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINM 276 Query: 234 PDYKPYPMYPATTSL--VNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCP 291 P+ T + + PK ++ DLL +L NP +RI+ EEAL HPY + Sbjct: 277 KARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYD 336 Query: 292 P 292 P Sbjct: 337 P 337 >2F9G-A nrPDB Length = 353 Score = 188 bits (478), Expect = 2e-48, Method: Compositional matrix adjust. Identities = 113/302 (37%), Positives = 164/302 (54%), Gaps = 24/302 (7%) Query: 10 IGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDV 69 +GEG YG V A ++ T EIVA+K++ D LREI +LK KH+NI+ + ++ Sbjct: 19 LGEGAYGVVCSATHKPTGEIVAIKKIE-PFDKPLFALRTLREIKILKHFKHENIITIFNI 77 Query: 70 LHSDK-----KLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLH 124 D ++ ++ E DL + + L + ++ F++Q L+ + H NV+H Sbjct: 78 QRPDSFENFNEVYIIQELMQTDLHRVIST--QMLSDDHIQYFIYQTLRAVKVLHGSNVIH 135 Query: 125 RDLKPQNLLINRNGELKLADFGLARAFGIPV----------RCYSAEVVTLWYRPPDVLF 174 RDLKP NLLIN N +LK+ DFGLAR + V T WYR P+V+ Sbjct: 136 RDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVML 195 Query: 175 GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLP 234 + YS ++D+WS GCI AEL RP+FPG D QL IF ++GTP + + P Sbjct: 196 TSAKYSRAMDVWSCGCILAELF-LRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESP 254 Query: 235 DYKPY----PMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFC 290 + Y PMYPA L + P++N G DLLQ +L +P +RI+A+EAL+HPY + Sbjct: 255 RAREYIKSLPMYPA-APLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQTYH 313 Query: 291 PP 292 P Sbjct: 314 DP 315 >4ZSG-A nrPDB Length = 347 Score = 186 bits (472), Expect = 1e-47, Method: Compositional matrix adjust. Identities = 117/314 (37%), Positives = 162/314 (51%), Gaps = 38/314 (12%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62 +YE +E IG G YG V A+ R T + VA+K++ D LRE+ +LK KH N Sbjct: 8 EYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDN 67 Query: 63 IVRLHDVLHSD------KKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGF 116 I+ + D+L K + +V + + DL + S L E V+ FL+QLL+GL + Sbjct: 68 IIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQ-PLTLEHVRYFLYQLLRGLKY 126 Query: 117 CHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYS-AE--------VVTLWY 167 HS V+HRDLKP NLL+N N ELK+ DFG+AR C S AE V T WY Sbjct: 127 MHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGL-----CTSPAEHQYFMTEYVATRWY 181 Query: 168 RPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPT---- 223 R P+++ Y+ +ID+WS GCIF E+ A R LFPG + QL+ I +LGTP+ Sbjct: 182 RAPELMLSLHEYTQAIDLWSVGCIFGEML-ARRQLFPGKNYVHQLQLIMMVLGTPSPAVI 240 Query: 224 -----EEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAE 278 E + LP +P P V P + LL +L+ P RISA Sbjct: 241 QAVGAERVRAYIQSLPPRQPVPWE-------TVYPGADRQALSLLGRMLRFEPSARISAA 293 Query: 279 EALQHPYFSDFCPP 292 AL+HP+ + + P Sbjct: 294 AALRHPFLAKYHDP 307 >5Z33-A nrPDB Length = 425 Score = 186 bits (471), Expect = 2e-47, Method: Compositional matrix adjust. Identities = 116/296 (39%), Positives = 162/296 (54%), Gaps = 13/296 (4%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELK-H 60 ++Y +++G+G YG V A N +T E VA+K+V + + ALREI LL+ + H Sbjct: 31 ERYTVTKELGQGAYGIVCAAVNNQTSEGVAIKKVTNVFSKKILAKRALREIKLLQHFRGH 90 Query: 61 KNIVRLHDV----LHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGF 116 +NI L+D+ + + L E + DL S D +SF++Q+L GL + Sbjct: 91 RNITCLYDMDIPRPDNFNETYLYEELMECDLAAIIRSGQPLTDAHF-QSFIYQILCGLKY 149 Query: 117 CHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVR---CYSAE-VVTLWYRPPDV 172 HS NVLHRDLKP NLL+N + ELK+ DFGLAR F + Y E V T WYR P++ Sbjct: 150 IHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSVDPEENAGYMTEYVATRWYRAPEI 209 Query: 173 LFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMT- 231 + + Y+ +ID+WS GCI AEL GRP F G D DQL +I +LGTP EE + Sbjct: 210 MLSFQSYTKAIDVWSVGCILAELL-GGRPFFKGRDYVDQLNQILHILGTPNEETLSRIGS 268 Query: 232 -KLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286 + +Y + A + P N DLL +L +P RIS E+AL+HPY Sbjct: 269 PRAQEYVRNLPFMAKKPFPTLFPNANPDALDLLDRMLAFDPSSRISVEQALEHPYL 324 >4IC8-A nrPDB Length = 442 Score = 185 bits (469), Expect = 2e-47, Method: Compositional matrix adjust. Identities = 117/314 (37%), Positives = 162/314 (51%), Gaps = 38/314 (12%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62 +YE +E IG G YG V A+ R T + VA+K++ D LRE+ +LK KH N Sbjct: 56 EYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDN 115 Query: 63 IVRLHDVLHSD------KKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGF 116 I+ + D+L K + +V + + DL + S L E V+ FL+QLL+GL + Sbjct: 116 IIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQ-PLTLEHVRYFLYQLLRGLKY 174 Query: 117 CHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYS-AE--------VVTLWY 167 HS V+HRDLKP NLL+N N ELK+ DFG+AR C S AE V T WY Sbjct: 175 MHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGL-----CTSPAEHQYFMTEYVATRWY 229 Query: 168 RPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPT---- 223 R P+++ Y+ +ID+WS GCIF E+ A R LFPG + QL+ I +LGTP+ Sbjct: 230 RAPELMLSLHEYTQAIDLWSVGCIFGEML-ARRQLFPGKNYVHQLQLIMMVLGTPSPAVI 288 Query: 224 -----EEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAE 278 E + LP +P P V P + LL +L+ P RISA Sbjct: 289 QAVGAERVRAYIQSLPPRQPVPWE-------TVYPGADRQALSLLGRMLRFEPSARISAA 341 Query: 279 EALQHPYFSDFCPP 292 AL+HP+ + + P Sbjct: 342 AALRHPFLAKYHDP 355 >4CRL-A nrPDB Length = 406 Score = 184 bits (468), Expect = 3e-47, Method: Compositional matrix adjust. Identities = 118/315 (37%), Positives = 182/315 (57%), Gaps = 42/315 (13%) Query: 9 KIGEGTYGTVFKAKNRETHEIV--ALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRL 66 K+G GTYG V+KAK ++ + ALK++ + G+ SA REI LL+ELKH N++ L Sbjct: 29 KVGRGTYGHVYKAKRKDGKDDKDYALKQI----EGTGISMSACREIALLRELKHPNVISL 84 Query: 67 HDVL--HSDKKLTLVFEFCDQDLK---KYFDSCNGDLDP-----EIVKSFLFQLLKGLGF 116 V H+D+K+ L+F++ + DL K+ + + P +VKS L+Q+L G+ + Sbjct: 85 QKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHY 144 Query: 117 CHSRNVLHRDLKPQNLLIN----RNGELKLADFGLARAFGIPVRCYS---AEVVTLWYRP 169 H+ VLHRDLKP N+L+ G +K+AD G AR F P++ + VVT WYR Sbjct: 145 LHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRA 204 Query: 170 PDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVD---------DQLKRIFRLLG 220 P++L GA+ Y+ +ID+W+ GCIFAEL + P+F D DQL RIF ++G Sbjct: 205 PELLLGARHYTKAIDIWAIGCIFAELLTS-EPIFHCRQEDIKTSNPYHHDQLDRIFNVMG 263 Query: 221 TPTEEQWPSMTKLPDY----KPYPMYPATT-SLVNVVPKL----NATGRDLLQNLLKCNP 271 P ++ W + K+P++ K + T SL+ + K ++ LLQ LL +P Sbjct: 264 FPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDP 323 Query: 272 VQRISAEEALQHPYF 286 ++RI++E+A+Q PYF Sbjct: 324 IKRITSEQAMQDPYF 338 >3OZ6-A nrPDB Length = 388 Score = 180 bits (457), Expect = 6e-46, Method: Compositional matrix adjust. Identities = 115/334 (34%), Positives = 179/334 (53%), Gaps = 45/334 (13%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELK- 59 ++KYE ++K+G+G YG V+K+ +R T E+VA+K++ + REI +L EL Sbjct: 8 LRKYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIFDAFQNSTDAQRTFREIMILTELSG 67 Query: 60 HKNIVRLHDVLHSD--KKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFC 117 H+NIV L +VL +D + + LVF++ + DL + L+P + ++QL+K + + Sbjct: 68 HENIVNLLNVLRADNDRDVYLVFDYMETDLHAVIRA--NILEPVHKQYVVYQLIKVIKYL 125 Query: 118 HSRNVLHRDLKPQNLLINRNGELKLADFGLARAF--------GIPVR------------- 156 HS +LHRD+KP N+L+N +K+ADFGL+R+F IP+ Sbjct: 126 HSGGLLHRDMKPSNILLNAECHVKVADFGLSRSFVNIRRVTNNIPLSINENTENFDDDQP 185 Query: 157 CYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIF 216 + V T WYR P++L G+ Y+ IDMWS GCI E+ G+P+FPG+ +QL+RI Sbjct: 186 ILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEIL-CGKPIFPGSSTMNQLERII 244 Query: 217 RLLGTPTEEQWPSM------TKLPDYKPYPMYPATTS----------LVNVVPKL--NAT 258 ++ P+ E S+ T + K + L+ + PK N Sbjct: 245 GVIDFPSNEDVESIQSPFAKTMIESLKEKVEIRQSNKRDIFTKWKNLLLKINPKADCNEE 304 Query: 259 GRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 292 DLL LL+ NP +RISA +AL+HP+ S F P Sbjct: 305 ALDLLDKLLQFNPNKRISANDALKHPFVSIFHNP 338 >5NGU-A nrPDB Length = 381 Score = 177 bits (449), Expect = 4e-45, Method: Compositional matrix adjust. Identities = 107/301 (35%), Positives = 162/301 (53%), Gaps = 16/301 (5%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62 +Y L IGEG YG V A + VA+K++ + + LREI +L +H+N Sbjct: 43 RYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKIS-PFEHQTYCQRTLREIKILLRFRHEN 101 Query: 63 IVRLHDVLHSD-----KKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFC 117 I+ ++D++ + K + +V + + DL K + + L + + FL+Q+L+GL + Sbjct: 102 IIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQH--LSNDHICYFLYQILRGLKYI 159 Query: 118 HSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSA----EVVTLWYRPPDVL 173 HS NVLHRDLKP NLL+N +LK+ DFGLAR P ++ V T WYR P+++ Sbjct: 160 HSANVLHRDLKPSNLLLNTTCDLKICDFGLARV-ADPDHDHTGFLTEYVATRWYRAPEIM 218 Query: 174 FGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKL 233 +K Y+ SID+WS GCI AE+ + RP+FPG DQL I +LG+P++E + L Sbjct: 219 LNSKGYTKSIDIWSVGCILAEML-SNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINL 277 Query: 234 PDYKPYPMYPATTSL--VNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCP 291 P + + P ++ DLL +L NP +RI E+AL HPY + Sbjct: 278 KARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYD 337 Query: 292 P 292 P Sbjct: 338 P 338 >3GC9-A nrPDB Length = 370 Score = 176 bits (445), Expect = 2e-44, Method: Compositional matrix adjust. Identities = 108/303 (35%), Positives = 157/303 (51%), Gaps = 22/303 (7%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 Q+ + L +G G YG+V A + + VA+K++ RE+ LLK LKH+ Sbjct: 28 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHE 87 Query: 62 NIVRLHDV------LHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLG 115 N++ L DV + ++ LV DL S L E V+ ++QLL+GL Sbjct: 88 NVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKSQA--LSDEHVQFLVYQLLRGLK 145 Query: 116 FCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFG 175 + HS ++HRDLKP N+ +N + EL++ DFGLAR + Y V T WYR P+++ Sbjct: 146 YIHSAGIIHRDLKPSNVAVNEDSELRILDFGLARQADEEMTGY---VATRWYRAPEIMLN 202 Query: 176 AKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSM----- 230 Y+ ++D+WS GCI AEL G+ LFPG+D DQLKRI ++GTP+ E + Sbjct: 203 WMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHA 261 Query: 231 -TKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDF 289 T + P P L ++ N DLL +L + QR+SA EAL H YFS + Sbjct: 262 RTYIQSLPPMPQ----KDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQY 317 Query: 290 CPP 292 P Sbjct: 318 HDP 320 >4MYG-A nrPDB Length = 372 Score = 175 bits (443), Expect = 2e-44, Method: Compositional matrix adjust. Identities = 105/295 (35%), Positives = 157/295 (53%), Gaps = 23/295 (7%) Query: 10 IGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDV 69 +G G YG+V A ++ + E VA+K++ E A RE+ LLK ++H+N++ L DV Sbjct: 51 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 110 Query: 70 LHSDKKLT------LVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVL 123 L LV F DL+K + E ++ ++Q+LKGL + HS V+ Sbjct: 111 FTPASSLRNFYDFYLVMPFMQTDLQKIM---GMEFSEEKIQYLVYQMLKGLKYIHSAGVV 167 Query: 124 HRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSI 183 HRDLKP NL +N + ELK+ DFGLAR + Y VVT WYR P+V+ Y+ ++ Sbjct: 168 HRDLKPGNLAVNEDCELKILDFGLARHADAEMTGY---VVTRWYRAPEVILSWMHYNQTV 224 Query: 184 DMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPD------YK 237 D+WS GCI AE+ G+ LF G D DQL +I ++ G P E + KL D + Sbjct: 225 DIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQILKVTGVPGTE---FVQKLNDKAAKSYIQ 280 Query: 238 PYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 292 P P + P+ + DLL+ +L+ + +R++A +AL HP+F F P Sbjct: 281 SLPQTP-RKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDP 334 >3N9X-A nrPDB Length = 432 Score = 174 bits (442), Expect = 3e-44, Method: Compositional matrix adjust. Identities = 115/335 (34%), Positives = 170/335 (50%), Gaps = 57/335 (17%) Query: 10 IGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDV 69 IG G+YG V+ A ++ T + VA+K+V +D LREI +L LK I+RL+D+ Sbjct: 34 IGRGSYGYVYLAYDKNTEKNVAIKKVNRMFEDLIDCKRILREITILNRLKSDYIIRLYDL 93 Query: 70 LHSDK-----KLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLH 124 + D +L +V E D DLKK F + L E +K+ L+ LL G F H ++H Sbjct: 94 IIPDDLLKFDELYIVLEIADSDLKKLFKTPIF-LTEEHIKTILYNLLLGENFIHESGIIH 152 Query: 125 RDLKPQNLLINRNGELKLADFGLARAFGIP----------------------VRCYSAEV 162 RDLKP N L+N++ +K+ DFGLAR + ++ V Sbjct: 153 RDLKPANCLLNQDCSVKVCDFGLARTINSEKDTNIVNDLEENEEPGPHNKNLKKQLTSHV 212 Query: 163 VTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGR----------PLFPGNDV---- 208 VT WYR P+++ + Y+ SID+WS GCIFAEL N + PLFPG+ Sbjct: 213 VTRWYRAPELILLQENYTKSIDIWSTGCIFAELLNMLQSHINDPTNRFPLFPGSSCFPLS 272 Query: 209 -------------DDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYP--ATTSLVNVVP 253 DQL IF ++GTPTE+ ++ K K ++P +L P Sbjct: 273 PDRNSKKVHEKSNRDQLNIIFNIIGTPTEDDLKNINKPEVIKYIKLFPHRKPINLKQKYP 332 Query: 254 KLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288 ++ G +LL+++LK NP +RI+ ++AL HPY D Sbjct: 333 SISDDGINLLESMLKFNPNKRITIDQALDHPYLKD 367 >4E7W-A nrPDB Length = 394 Score = 172 bits (437), Expect = 1e-43, Method: Compositional matrix adjust. Identities = 110/304 (36%), Positives = 169/304 (55%), Gaps = 35/304 (11%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 Y + IG G++G VF+AK E+ E VA+K+V D + RE+ +++ +KH N+ Sbjct: 42 YTNCKVIGNGSFGVVFQAKLVESDE-VAIKKVLQDKRFKN------RELQIMRIVKHPNV 94 Query: 64 VRLHDVLHS--DKK----LTLVFEFCDQDL---KKYFDSCNGDLDPEIVKSFLFQLLKGL 114 V L +S DKK L LV E+ + + +++ + ++K +++QLL+ L Sbjct: 95 VDLKAFFYSNGDKKDEVFLNLVLEYVPETVYRASRHYAKLKQTMPMLLIKLYMYQLLRSL 154 Query: 115 GFCHSRNVLHRDLKPQNLLINR-NGELKLADFGLARAF--GIPVRCYSAEVVTLWYRPPD 171 + HS + HRD+KPQNLL++ +G LKL DFG A+ G P Y + + +YR P+ Sbjct: 155 AYIHSIGICHRDIKPQNLLLDPPSGVLKLIDFGSAKILIAGEPNVSY---ICSRYYRAPE 211 Query: 172 VLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMT 231 ++FGA Y+T+ID+WS GC+ AEL G+PLFPG DQL I ++LGTP+ EQ +M Sbjct: 212 LIFGATNYTTNIDIWSTGCVMAELMQ-GQPLFPGESGIDQLVEIIKVLGTPSREQIKTMN 270 Query: 232 ------KLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPY 285 K P +P+P P+ DL+ LL+ P R++A EAL HP+ Sbjct: 271 PNYMEHKFPQIRPHPFSKVFR------PRTPPDAIDLISRLLEYTPSARLTAIEALCHPF 324 Query: 286 FSDF 289 F + Sbjct: 325 FDEL 328 >4EWQ-A nrPDB Length = 383 Score = 172 bits (437), Expect = 1e-43, Method: Compositional matrix adjust. Identities = 107/299 (35%), Positives = 157/299 (52%), Gaps = 14/299 (4%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 ++Y+ L +G G YG+V A + +T VA+K++ RE+ LLK +KH+ Sbjct: 45 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 104 Query: 62 NIVRLHDVLHSDKKLT------LVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLG 115 N++ L DV + L LV DL C L + V+ ++Q+L+GL Sbjct: 105 NVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIV-KCQ-KLTDDHVQFLIYQILRGLK 162 Query: 116 FCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFG 175 + HS +++HRDLKP NL +N + ELK+ DFGLAR + Y V T WYR P+++ Sbjct: 163 YIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGY---VATRWYRAPEIMLN 219 Query: 176 AKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMT--KL 233 Y+ ++D+WS GCI AEL GR LFPG D DQLK I RL+GTP E ++ Sbjct: 220 WMHYNQTVDIWSVGCIMAELL-TGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESA 278 Query: 234 PDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 292 +Y + NV N DLL+ +L + +RI+A +AL H YF+ + P Sbjct: 279 RNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDP 337 >1CM8-A nrPDB Length = 367 Score = 172 bits (436), Expect = 2e-43, Method: Compositional matrix adjust. Identities = 105/298 (35%), Positives = 158/298 (53%), Gaps = 28/298 (9%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 Y L+ +G G YG V A + T VA+K++ E A RE+ LLK ++H+N+ Sbjct: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 Query: 64 VRLHDVLHSDKKLT------LVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFC 117 + L DV D+ L LV F DL K + L + ++ ++Q+LKGL + Sbjct: 87 IGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMK--HEKLGEDRIQFLVYQMLKGLRYI 144 Query: 118 HSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAK 177 H+ ++HRDLKP NL +N + ELK+ DFGLAR + Y VVT WYR P+V+ Sbjct: 145 HAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGY---VVTRWYRAPEVILNWM 201 Query: 178 LYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTP---------TEEQWP 228 Y+ ++D+WS GCI AE+ G+ LF G+D DQLK I ++ GTP ++E Sbjct: 202 RYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKN 260 Query: 229 SMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286 M LP+ + +++ + +LL+ +L + QR++A EAL HPYF Sbjct: 261 YMKGLPELE-------KKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF 311 >4O2Z-A nrPDB Length = 377 Score = 171 bits (432), Expect = 4e-43, Method: Compositional matrix adjust. Identities = 104/303 (34%), Positives = 166/303 (54%), Gaps = 29/303 (9%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVR--LDDDDEGVPSSALREICLLKELK 59 KY L+ +G G YG + +T E V++K+ R D ++G LREI +++ Sbjct: 45 SKYTLLKILGMGAYGIACSCLDGDTGEKVSIKKCRDVFRDVEDG--KRVLREIDMMRFFH 102 Query: 60 HKNIVRLHDVL-------HSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLK 112 H+N++ + ++L HS + + +V D D+ S L+ ++ F++Q+L+ Sbjct: 103 HENLLNVVNILPPLKREYHSFEDVYVVTPLMDVDMNVVLRS-RQVLEESHMQYFVYQILR 161 Query: 113 GLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDV 172 GL + HS NV HRDLKP NL+ N + ELK+ DFGL+R+ +P + V+T WYRPP++ Sbjct: 162 GLKYLHSANVAHRDLKPANLVTNISCELKIIDFGLSRSVDVPYSELTDYVITRWYRPPEL 221 Query: 173 LFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPT------EEQ 226 L YST++D+WS GCIFAE+ N +P+FPG + DQL+ I + +G P E Sbjct: 222 LLENTNYSTAVDIWSVGCIFAEMYNR-KPVFPGRNTMDQLRMIAQHIGKPPASIVEHREA 280 Query: 227 WPSMTKLPDYKPYPMYPATTSLVNVVPKL--NATGRDLLQNLLKCNPVQRISAEEALQHP 284 + +LPD + ++ +VP L N G D L + +P +R +A + L HP Sbjct: 281 LEKLNELPD--------GSLNIPKLVPGLAGNTEGIDFLSKMWTLDPSKRPTAADMLAHP 332 Query: 285 YFS 287 Y + Sbjct: 333 YLA 335 >3NIE-A nrPDB Length = 429 Score = 171 bits (432), Expect = 4e-43, Method: Compositional matrix adjust. Identities = 116/344 (33%), Positives = 170/344 (49%), Gaps = 60/344 (17%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 YE IG G+YG V+ A ++ ++ VA+K+V +D LREI +L LK I Sbjct: 30 YEIKHLIGRGSYGYVYLAYDKNANKNVAIKKVNRMFEDLIDCKRILREITILNRLKSDYI 89 Query: 64 VRLHDVLHSDK-----KLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCH 118 +RLHD++ + +L +V E D DLKK F + L + VK+ L+ LL G F H Sbjct: 90 IRLHDLIIPEDLLKFDELYIVLEIADSDLKKLFKTPIF-LTEQHVKTILYNLLLGEKFIH 148 Query: 119 SRNVLHRDLKPQNLLINRNGELKLADFGLARAFG----IPV------------------- 155 ++HRDLKP N L+N++ +K+ DFGLAR I + Sbjct: 149 ESGIIHRDLKPANCLLNQDCSVKICDFGLARTINSDKDIHIVNDLEEKEENEEPGPHNKN 208 Query: 156 --RCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGR----------PLF 203 + ++ VVT WYR P+++ + Y+ SID+WS GCIFAEL N + PLF Sbjct: 209 LKKQLTSHVVTRWYRAPELILLQENYTNSIDIWSTGCIFAELLNMMKSHINNPTNRFPLF 268 Query: 204 PGNDV-----------------DDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT- 245 PG+ DQL IF ++GTP EE +TK K ++P Sbjct: 269 PGSSCFPLSPDHNSKKVHEKSNRDQLNIIFNVIGTPPEEDLKCITKQEVIKYIKLFPTRD 328 Query: 246 -TSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288 L ++ G DLL+++L+ N +RI+ ++AL HPY D Sbjct: 329 GIDLSKKYSSISKEGIDLLESMLRFNAQKRITIDKALSHPYLKD 372 >3OHT-A nrPDB Length = 389 Score = 171 bits (432), Expect = 4e-43, Method: Compositional matrix adjust. Identities = 106/300 (35%), Positives = 158/300 (52%), Gaps = 16/300 (5%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 ++Y+ L +G G YG+V + + ++ +A+K++ RE+ LLK +KH+ Sbjct: 51 ERYQTLSPVGSGAYGSVCSSYDVKSGLKIAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 110 Query: 62 NIVRLHDV------LHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLG 115 N++ L DV L + LV DL C L + V+ ++Q+L+GL Sbjct: 111 NVIGLLDVFTPATSLEEFNDVYLVTHLMGADLNNIV-KCQ-KLTDDHVQFLIYQILRGLK 168 Query: 116 FCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFG 175 + HS +++HRDLKP NL +N + ELK+ DFGLAR + Y V T WYR P+++ Sbjct: 169 YIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGY---VATRWYRAPEIMLN 225 Query: 176 AKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTE---EQWPSMTK 232 Y+ ++D+WS GCI AEL GR LFPG D +QL++I RL GTP + PS Sbjct: 226 WMHYNMTVDIWSVGCIMAELL-TGRTLFPGTDHINQLQQIMRLTGTPPASVISRMPSHEA 284 Query: 233 LPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 292 P P + +V N DLL+ +L + +RI+A EAL HPYFS + P Sbjct: 285 RNYINSLPQMPK-RNFADVFIGANPLAVDLLEKMLVLDTDKRITASEALAHPYFSQYHDP 343 >2I6L-A nrPDB Length = 320 Score = 167 bits (424), Expect = 4e-42, Method: Compositional matrix adjust. Identities = 114/313 (36%), Positives = 169/313 (53%), Gaps = 32/313 (10%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSS---ALREICLLKELK 59 +Y L+ +G G G VF A + + + VA+K++ L D P S ALREI +++ L Sbjct: 12 RYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTD-----PQSVKHALREIKIIRRLD 66 Query: 60 HKNIVRLHDVLH-SDKKLT-------------LVFEFCDQDLKKYFDSCNGDLDPEIVKS 105 H NIV++ ++L S +LT +V E+ + DL + G L E + Sbjct: 67 HDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLE--QGPLLEEHARL 124 Query: 106 FLFQLLKGLGFCHSRNVLHRDLKPQNLLIN-RNGELKLADFGLARAFGIPVRCY----SA 160 F++QLL+GL + HS NVLHRDLKP NL IN + LK+ DFGLAR P + S Sbjct: 125 FMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMD-PHYSHKGHLSE 183 Query: 161 EVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLG 220 +VT WYR P +L Y+ +IDMW+AGCIFAE+ G+ LF G +Q++ I + Sbjct: 184 GLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEML-TGKTLFAGAHELEQMQLILESIP 242 Query: 221 TPTEE-QWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEE 279 EE + ++ +P Y M L ++P ++ D L+ +L +P+ R++AEE Sbjct: 243 VVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREAVDFLEQILTFSPMDRLTAEE 302 Query: 280 ALQHPYFSDFCPP 292 AL HPY S + P Sbjct: 303 ALSHPYMSIYSFP 315 >3RP9-A nrPDB Length = 458 Score = 160 bits (405), Expect = 6e-40, Method: Compositional matrix adjust. Identities = 113/350 (32%), Positives = 167/350 (47%), Gaps = 65/350 (18%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62 +YE IG G+YG V +A ++ +VA+K++ +D LREI +L L H + Sbjct: 54 RYEIRHLIGTGSYGHVCEAYDKLEKRVVAIKKILRVFEDLIDCKRILREIAILNRLNHDH 113 Query: 63 IVRLHDVL-----HSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFC 117 +V++ D++ +L +V E D D KK F + L +K+ L+ LL G+ + Sbjct: 114 VVKVLDIVIPKDVEKFDELYVVLEIADSDFKKLFRTPVY-LTELHIKTLLYNLLVGVKYV 172 Query: 118 HSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIP----------------------- 154 HS +LHRDLKP N L+N++ +K+ DFGLAR P Sbjct: 173 HSAGILHRDLKPANCLVNQDCSVKVCDFGLARTVDYPENGNSQLPISPREDDMNLVTFPH 232 Query: 155 ----VRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGR---------- 200 R + VVT WYR P+++ + Y+ +ID+WS GCIFAEL N + Sbjct: 233 TKNLKRQLTGHVVTRWYRAPELILLQENYTEAIDVWSIGCIFAELLNMIKENVAYHADRG 292 Query: 201 PLFP-------------GNDVD-------DQLKRIFRLLGTPTEEQWPSMTKLPDYKPYP 240 PLFP GND DQL IF +LGTP+EE ++ K + Sbjct: 293 PLFPGSSCFPLSPDQKAGNDFKFHTRGNRDQLNVIFNILGTPSEEDIEALEKEDAKRYIR 352 Query: 241 MYPAT--TSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288 ++P T L P +A LL+ +L NP +RI+ E L HP+F + Sbjct: 353 IFPKREGTDLAERFPASSADAIHLLKRMLVFNPNKRITINECLAHPFFKE 402 >5AIR-A nrPDB Length = 430 Score = 160 bits (405), Expect = 6e-40, Method: Compositional matrix adjust. Identities = 106/303 (34%), Positives = 165/303 (54%), Gaps = 26/303 (8%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 Y + IG G++G V++AK ++ E+VA+K+V D + RE+ ++++L H NI Sbjct: 66 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN------RELQIMRKLDHCNI 119 Query: 64 VRLHDVLHS--DKK----LTLVFEFCDQDL---KKYFDSCNGDLDPEIVKSFLFQLLKGL 114 VRL +S +KK L LV ++ + + +++ L VK +++QL + L Sbjct: 120 VRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 179 Query: 115 GFCHSRNVLHRDLKPQNLLINRN-GELKLADFGLARAF--GIPVRCYSAEVVTLWYRPPD 171 + HS + HRD+KPQNLL++ + LKL DFG A+ G P Y + + +YR P+ Sbjct: 180 AYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSY---ICSRYYRAPE 236 Query: 172 VLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMT 231 ++FGA Y++SID+WSAGC+ AEL G+P+FPG+ DQL I ++LGTPT EQ M Sbjct: 237 LIFGATDYTSSIDVWSAGCVLAELL-LGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMN 295 Query: 232 KLPDYK--PYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDF 289 P+Y +P A P+ L LL+ P R++ EA H +F + Sbjct: 296 --PNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDEL 353 Query: 290 CPP 292 P Sbjct: 354 RDP 356 >1JNK-A nrPDB Length = 423 Score = 160 bits (404), Expect = 9e-40, Method: Compositional matrix adjust. Identities = 106/316 (33%), Positives = 161/316 (50%), Gaps = 35/316 (11%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 +++Y+ L+ IG G G V A + VA+K++ ++ A RE+ L+K + H Sbjct: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120 Query: 61 KNIVRLHDVLHSDKKLT------LVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGL 114 KNI+ L +V K L LV E D +L + +LD E + L+Q+L G+ Sbjct: 121 KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQM---ELDHERMSYLLYQMLCGI 177 Query: 115 GFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLF 174 HS ++HRDLKP N+++ + LK+ DFGLAR G + VVT +YR P+V+ Sbjct: 178 KHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMM-TPYVVTRYYRAPEVIL 236 Query: 175 GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEE--------- 225 G Y ++D+WS GCI E+ + LFPG D DQ ++ LGTP E Sbjct: 237 GMG-YKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTV 294 Query: 226 --------QWPSMTKLPDYKPYPMYPATTSLVNVVPKLNAT-GRDLLQNLLKCNPVQRIS 276 ++ +T P P ++PA + KL A+ RDLL +L +P +RIS Sbjct: 295 RNYVENRPKYAGLT-FPKLFPDSLFPADSEH----NKLKASQARDLLSKMLVIDPAKRIS 349 Query: 277 AEEALQHPYFSDFCPP 292 ++ALQHPY + + P Sbjct: 350 VDDALQHPYINVWYDP 365 >3FI2-A nrPDB Length = 353 Score = 159 bits (402), Expect = 1e-39, Method: Compositional matrix adjust. Identities = 105/311 (33%), Positives = 159/311 (51%), Gaps = 35/311 (11%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 +++Y+ L+ IG G G V A + VA+K++ ++ A RE+ L+K + H Sbjct: 23 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 82 Query: 61 KNIVRLHDVLHSDKKLT------LVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGL 114 KNI+ L +V K L LV E D +L + +LD E + L+Q+L G+ Sbjct: 83 KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQM---ELDHERMSYLLYQMLCGI 139 Query: 115 GFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLF 174 HS ++HRDLKP N+++ + LK+ DFGLAR G + VVT +YR P+V+ Sbjct: 140 KHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF-MMTPYVVTRYYRAPEVIL 198 Query: 175 GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEE--------- 225 G Y ++D+WS GCI E+ + LFPG D DQ ++ LGTP E Sbjct: 199 GMG-YKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTV 256 Query: 226 --------QWPSMTKLPDYKPYPMYPATTSLVNVVPKLNAT-GRDLLQNLLKCNPVQRIS 276 ++ +T P P ++PA + KL A+ RDLL +L +P +RIS Sbjct: 257 RNYVENRPKYAGLT-FPKLFPDSLFPADSEH----NKLKASQARDLLSKMLVIDPAKRIS 311 Query: 277 AEEALQHPYFS 287 ++ALQHPY + Sbjct: 312 VDDALQHPYIN 322 >2XS0-A nrPDB Length = 386 Score = 157 bits (397), Expect = 5e-39, Method: Compositional matrix adjust. Identities = 111/315 (35%), Positives = 160/315 (50%), Gaps = 33/315 (10%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 +++Y+ L+ IG G G V A + VA+K++ ++ A RE+ L+K + H Sbjct: 25 LKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 84 Query: 61 KNIVRLHDVLHSDKKLT------LVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGL 114 KNI+ L +V K L +V E D +L + +LD E + L+Q+L G+ Sbjct: 85 KNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQM---ELDHERMSYLLYQMLCGI 141 Query: 115 GFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLF 174 HS ++HRDLKP N+++ + LK+ DFGLAR G VVT +YR P+V+ Sbjct: 142 KHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMVPF-VVTRYYRAPEVIL 200 Query: 175 GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKL- 233 G Y ++D+WS GCI E+ G LFPG D DQ ++ LGTP E M KL Sbjct: 201 GMG-YKENVDIWSVGCIMGEMIKGG-VLFPGTDHIDQWNKVIEQLGTPCPE---FMKKLQ 255 Query: 234 PDYKPY----PMYPATTSLVNVVP-----------KLNAT-GRDLLQNLLKCNPVQRISA 277 P + Y P Y A S + P KL A+ RDLL +L + +RIS Sbjct: 256 PTVRTYVENRPKY-AGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISV 314 Query: 278 EEALQHPYFSDFCPP 292 +EALQHPY + + P Sbjct: 315 DEALQHPYINVWYDP 329 >4QNY-A nrPDB Length = 354 Score = 156 bits (394), Expect = 1e-38, Method: Compositional matrix adjust. Identities = 95/287 (33%), Positives = 152/287 (52%), Gaps = 11/287 (3%) Query: 10 IGEGTYGTVFKAKNRET-HEIVALKRVRLDDDDEGV-PSSALREICLLKELKHKNIVRLH 67 IG G+YG V +A++ ++ + +VA+KRV + +E + LREI LL NI+ L Sbjct: 28 IGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFEEVILAKRILREIKLLAHFNDDNIIGLR 87 Query: 68 DVLHSDK-----KLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNV 122 ++L + +V + + DLK+ S +L ++ F++Q L+ L HS V Sbjct: 88 NILTPEDPENFDHFYIVMDIMETDLKQVLRSGQ-ELTEAHIQFFIYQALRALHIIHSAGV 146 Query: 123 LHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTS 182 +HRD+ P N+L+N N +LK+ DFGLA+ + V WYR P+++ K YS Sbjct: 147 IHRDITPANILVNTNCDLKICDFGLAKEENDQGEYMTDYVTMRWYRAPELVMEDKDYSAQ 206 Query: 183 IDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSM--TKLPDYKPYP 240 ID+W GCI EL + RPLF G D +QL +I ++GTP+EE S+ + Y Sbjct: 207 IDVWGIGCILGELLGS-RPLFQGKDRVNQLDKIVDVIGTPSEEDINSVGSSAAQKYLKKK 265 Query: 241 MYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFS 287 + P + DLL+++L NP +RI+ +A++HP+ Sbjct: 266 SHRPQADWRQRYPTASPEALDLLRHMLVFNPKRRITVLQAMRHPFLE 312 >3E7O-A nrPDB Length = 360 Score = 154 bits (389), Expect = 4e-38, Method: Compositional matrix adjust. Identities = 104/314 (33%), Positives = 159/314 (50%), Gaps = 31/314 (9%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 +++Y++L+ IG G G V A + VA+K++ ++ A RE+ LLK + H Sbjct: 21 LKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNH 80 Query: 61 KNIVRLHDVLHSDKKLT------LVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGL 114 KNI+ L +V K L LV E D +L + + +LD E + L+Q+L G+ Sbjct: 81 KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI---HMELDHERMSYLLYQMLCGI 137 Query: 115 GFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLF 174 HS ++HRDLKP N+++ + LK+ DFGLAR + VVT +YR P+V+ Sbjct: 138 KHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTASTNFMM-TPYVVTRYYRAPEVIL 196 Query: 175 GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLP 234 G Y ++D+WS GCI EL G +F G D DQ ++ LGTP+ E ++ P Sbjct: 197 GMG-YKENVDIWSVGCIMGELVK-GSVIFQGTDHIDQWNKVIEQLGTPSAEFMAALQ--P 252 Query: 235 DYKPY----PMYPATTSLVNVVPKL------------NATGRDLLQNLLKCNPVQRISAE 278 + Y P YP + + P + RDLL +L +P +RIS + Sbjct: 253 TVRNYVENRPAYPG-IAFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVD 311 Query: 279 EALQHPYFSDFCPP 292 EAL+HPY + + P Sbjct: 312 EALRHPYITVWYDP 325 >3E3P-A nrPDB Length = 360 Score = 152 bits (385), Expect = 1e-37, Method: Compositional matrix adjust. Identities = 108/313 (34%), Positives = 163/313 (52%), Gaps = 31/313 (9%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKEL-- 58 M +++ G+GT+GTV K + T VA+K+V D P RE+ ++++L Sbjct: 22 MDRFQVERMAGQGTFGTVQLGKEKSTGMSVAIKKVIQD------PRFRNRELQIMQDLAV 75 Query: 59 -KHKNIVRLHDVLHS-------DKKLTLVFEFCDQDL----KKYFDSCNGDLDPEIVKSF 106 H NIV+L ++ D L +V E+ L + Y+ P ++K F Sbjct: 76 LHHPNIVQLQSYFYTLGERDRRDIYLNVVMEYVPDTLHRCCRNYYRRQVAP-PPILIKVF 134 Query: 107 LFQLLKGLGFCH--SRNVLHRDLKPQNLLINR-NGELKLADFGLARAFGIPVRCYSAEVV 163 LFQL++ +G H S NV HRD+KP N+L+N +G LKL DFG A+ P A + Sbjct: 135 LFQLIRSIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKLS-PSEPNVAYIC 193 Query: 164 TLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPT 223 + +YR P+++FG + Y+T++D+WS GCIFAE+ G P+F G++ QL I R+LG P+ Sbjct: 194 SRYYRAPELIFGNQHYTTAVDIWSVGCIFAEMM-LGEPIFRGDNSAGQLHEIVRVLGCPS 252 Query: 224 EEQW----PSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEE 279 E PS T + Y + P + + K DLL LL+ P +R+ E Sbjct: 253 REVLRKLNPSHTDVDLYNSKGI-PWSNVFSDHSLKDAKEAYDLLSALLQYLPEERMKPYE 311 Query: 280 ALQHPYFSDFCPP 292 AL HPYF + P Sbjct: 312 ALCHPYFDELHDP 324 >3EB0-A nrPDB Length = 383 Score = 152 bits (383), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 103/329 (31%), Positives = 161/329 (48%), Gaps = 54/329 (16%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 +KY + +G G++G V + + E+ + ALK+V D P RE+ ++K L H Sbjct: 7 KKYSLGKTLGTGSFGIVCEVFDIESGKRFALKKVLQD------PRYKNRELDIMKVLDHV 60 Query: 62 NIVRLHDVLHS--------------------------------------DKKLTLVFEFC 83 NI++L D ++ +K L ++ E+ Sbjct: 61 NIIKLVDYFYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNVIMEYV 120 Query: 84 DQDLKKYFDS---CNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLIN-RNGE 139 L K S + ++ +++QL + +GF HS + HRD+KPQNLL+N ++ Sbjct: 121 PDTLHKVLKSFIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLLVNSKDNT 180 Query: 140 LKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAG 199 LKL DFG A+ IP A + + +YR P+++ GA Y+ SID+WS GC+F EL G Sbjct: 181 LKLCDFGSAKKL-IPSEPSVAYICSRFYRAPELMLGATEYTPSIDLWSIGCVFGELI-LG 238 Query: 200 RPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKP--YPMYPATTSLVNVVPKLNA 257 +PLF G DQL RI +++GTPT+EQ M P Y +P A + + Sbjct: 239 KPLFSGETSIDQLVRIIQIMGTPTKEQMIRMN--PHYTEVRFPTLKAKDWRKILPEGTPS 296 Query: 258 TGRDLLQNLLKCNPVQRISAEEALQHPYF 286 DLL+ +L+ P RI+ EA+ HP+F Sbjct: 297 LAIDLLEQILRYEPDLRINPYEAMAHPFF 325 >5AWM-A nrPDB Length = 394 Score = 147 bits (372), Expect = 4e-36, Method: Compositional matrix adjust. Identities = 102/305 (33%), Positives = 153/305 (50%), Gaps = 26/305 (8%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62 +Y L IG G G V A + T + VA+K++ + A RE L+K + HKN Sbjct: 45 RYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKN 104 Query: 63 IVRLHDVLHSDKKLT------LVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGF 116 I+ L + + L LV E D +L + DLD + + L+Q+L G+ Sbjct: 105 IIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQM---DLDHDRMSYLLYQMLCGIKH 161 Query: 117 CHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGA 176 HS ++HRDLKP N+++ + LK+ DFGLAR G + VVT +YR P+V+ G Sbjct: 162 LHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTF-MMTPYVVTRYYRAPEVILGM 220 Query: 177 KLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPT----EEQWPSMTK 232 Y+ ++D+WS GCI E+ G LFPG D DQ +I LGTP+ + P++ Sbjct: 221 G-YTENVDIWSVGCIMGEMIRGG-VLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRN 278 Query: 233 LPDYKP-YPMYPATTSLVN-VVPKLN--------ATGRDLLQNLLKCNPVQRISAEEALQ 282 + +P Y Y + + P N + R+LL +L +P QRIS +EAL+ Sbjct: 279 YVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALK 338 Query: 283 HPYFS 287 H Y + Sbjct: 339 HEYIN 343 >3PG1-A nrPDB Length = 362 Score = 145 bits (365), Expect = 3e-35, Method: Compositional matrix adjust. Identities = 102/302 (33%), Positives = 150/302 (49%), Gaps = 24/302 (7%) Query: 10 IGEGTYGTVFKAKNRETHEIVALKRV--RLDD-------DDEGVPSSALREICLLKELKH 60 I G+YG V + E VA+KRV + D D + LREI LL H Sbjct: 30 ISSGSYGAVCAGVDSEGIP-VAIKRVFNTVSDGRTVNILSDSFLCKRVLREIRLLNHFHH 88 Query: 61 KNIVRLHDV-LHSDK----KLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLG 115 NI+ L D+ +H ++ KL LV E DL + + P+ ++ F++ +L GL Sbjct: 89 PNILGLRDIFVHFEEPAMHKLYLVTELMRTDLAQVIHDQRIVISPQHIQYFMYHILLGLH 148 Query: 116 FCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFG 175 H V+HRDL P N+L+ N ++ + DF LAR + V WYR P+++ Sbjct: 149 VLHEAGVVHRDLHPGNILLADNNDITICDFNLAREDTADAN-KTHYVTHRWYRAPELVMQ 207 Query: 176 AKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPD 235 K ++ +DMWSAGC+ AE+ N + LF G+ +QL +I ++GTP E M P Sbjct: 208 FKGFTKLVDMWSAGCVMAEMFNR-KALFRGSTFYNQLNKIVEVVGTPKIED-VVMFSSPS 265 Query: 236 YKPY-----PMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFC 290 + Y PA + VVP + DL+ +L+ NP +RIS E+AL+HPYF Sbjct: 266 ARDYLRNSLSNVPA-RAWTAVVPTADPVALDLIAKMLEFNPQRRISTEQALRHPYFESLF 324 Query: 291 PP 292 P Sbjct: 325 DP 326 >6HMD-A nrPDB Length = 365 Score = 133 bits (334), Expect = 9e-32, Method: Compositional matrix adjust. Identities = 96/298 (32%), Positives = 158/298 (53%), Gaps = 27/298 (9%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH-KN 62 Y+ + K+G G Y VF+A N I +RV + RE+ +L+ L+ N Sbjct: 55 YQLVRKLGRGKYSEVFEAIN-----ITNNERVVVKILKPVKKKKIKREVKILENLRGGTN 109 Query: 63 IVRLHDVLHS--DKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 I++L D + K LVFE+ + D K+ + D D ++ ++++LLK L +CHS Sbjct: 110 IIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILT-DFD---IRFYMYELLKALDYCHS 165 Query: 120 RNVLHRDLKPQNLLIN-RNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL 178 + ++HRD+KP N++I+ + +L+L D+GLA F P + Y+ V + +++ P++L ++ Sbjct: 166 KGIMHRDVKPHNVMIDHQQKKLRLIDWGLAE-FYHPAQEYNVRVASRYFKGPELLVDYQM 224 Query: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKL----- 233 Y S+DMWS GC+ A + P F G D DQL RI ++LG TEE + + K Sbjct: 225 YDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLG--TEELYGYLKKYHIDLD 282 Query: 234 PDYKPYPMYPATTSLVNVVPKLNA-----TGRDLLQNLLKCNPVQRISAEEALQHPYF 286 P + + N + N DLL LL+ + QR++A+EA++HPYF Sbjct: 283 PHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 340 >5ZTN-A nrPDB Length = 429 Score = 129 bits (325), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 101/335 (30%), Positives = 161/335 (48%), Gaps = 61/335 (18%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62 +YE L+ IG+G++G V KA + + H+ VALK VR +++ A EI +L+ L+ ++ Sbjct: 98 RYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVR---NEKRFHRQAAEEIRILEHLRKQD 154 Query: 63 IVRLHDVLHSDKKLT------LVFEFCDQDLKKYF--DSCNGDLDPEIVKSFLFQLLKGL 114 +V+H + T + FE +L + + G P +V+ F +L+ L Sbjct: 155 KDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLP-LVRKFAHSILQCL 213 Query: 115 GFCHSRNVLHRDLKPQNLLINRNGE--LKLADFGLARAFGIPVRCYSAEVV-----TLWY 167 H ++H DLKP+N+L+ + G +K+ DFG + CY + V + +Y Sbjct: 214 DALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSS--------CYEHQRVYTYIQSRFY 265 Query: 168 RPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQW 227 R P+V+ GA+ Y IDMWS GCI AEL G PL PG D DQL + LLG P+++ Sbjct: 266 RAPEVILGAR-YGMPIDMWSLGCILAELL-TGYPLLPGEDEGDQLACMIELLGMPSQKLL 323 Query: 228 PSMTKLPDY---KPYPMYPATTSLVNVVPKLNATGR------------------------ 260 + + ++ K YP Y T+L + LN GR Sbjct: 324 DASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNG-GRSRRGKLRGPPESREWGNALKGCDD 382 Query: 261 ----DLLQNLLKCNPVQRISAEEALQHPYFSDFCP 291 D L+ L+ +P R++ +AL+HP+ P Sbjct: 383 PLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLP 417 >4UZD-A nrPDB Length = 287 Score = 129 bits (325), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 85/293 (29%), Positives = 144/293 (49%), Gaps = 44/293 (15%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRV-RLDDDDEGVPSSALREICLLKELK 59 ++ +E +G+G +G V+ A+ +++ I+ALK + + + GV RE+ + L+ Sbjct: 7 LEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLR 66 Query: 60 HKNIVRLHDVLHSDKKLTLVFEFCD-----QDLKKYFDSCNGDLDPEIVKSFLFQLLKGL 114 H NI+RL+ H ++ L+ E+ ++L+K D + +++ +L L Sbjct: 67 HPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKL-----SKFDEQRTATYITELANAL 121 Query: 115 GFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLF 174 +CHS+ V+HRD+KP+NLL+ GELK+ADFG + P + TL Y PP+++ Sbjct: 122 SYCHSKRVIHRDIKPENLLLGSAGELKIADFGW--SVHAPSSRRTTLCGTLDYLPPEMIE 179 Query: 175 GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLP 234 G +++ +D+WS G + E G+P F N + KRI R+ T P Sbjct: 180 G-RMHDEKVDLWSLGVLCYEFL-VGKPPFEANTYQETYKRISRVEFT-----------FP 226 Query: 235 DYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFS 287 D+ + RDL+ LLK NP QR E L+HP+ + Sbjct: 227 DF------------------VTEGARDLISRLLKHNPSQRPMLREVLEHPWIT 261 >3D2K-A nrPDB Length = 272 Score = 127 bits (320), Expect = 4e-30, Method: Compositional matrix adjust. Identities = 83/283 (29%), Positives = 140/283 (49%), Gaps = 44/283 (15%) Query: 10 IGEGTYGTVFKAKNRETHEIVALKRV-RLDDDDEGVPSSALREICLLKELKHKNIVRLHD 68 +G+G +G V+ A+ R++ I+ALK + + + GV RE+ + L+H NI+RL+ Sbjct: 20 LGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVEHQLRREVEIQSHLRHPNILRLYG 79 Query: 69 VLHSDKKLTLVFEFCD-----QDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVL 123 H ++ L+ E+ ++L+K D + +++ +L L +CHS+ V+ Sbjct: 80 YFHDATRVYLILEYAPLGTVYRELQKL-----SRFDEQRTATYITELANALSYCHSKRVI 134 Query: 124 HRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSI 183 HRD+KP+NLL+ NGELK+ADFG + P + TL Y PP+++ G +++ + Sbjct: 135 HRDIKPENLLLGSNGELKIADFGW--SVHAPSSRRTTLCGTLDYLPPEMIEG-RMHDEKV 191 Query: 184 DMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYP 243 D+WS G + E G P F + + +RI R+ T PD+ Sbjct: 192 DLWSLGVLCYEFL-VGMPPFEAHTYQETYRRISRVEFT-----------FPDF------- 232 Query: 244 ATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286 + RDL+ LLK N QR++ E L+HP+ Sbjct: 233 -----------VTEGARDLISRLLKHNASQRLTLAEVLEHPWI 264 >6O6Q-A nrPDB Length = 335 Score = 127 bits (319), Expect = 6e-30, Method: Compositional matrix adjust. Identities = 90/298 (30%), Positives = 157/298 (52%), Gaps = 24/298 (8%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSAL-REICLLKELKH 60 + YE L K+G G Y VF + E E V +K ++ V + REI +LK L Sbjct: 41 ENYEILRKLGRGKYSEVFLGIDLEKREKVVIKVLK------PVKRKKIKREISILKNLVD 94 Query: 61 K-NIVRLHDVLHSDKKLT--LVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFLFQLLKGLGF 116 NI+ + DV+ + T L+FE + D + + + D D ++ ++++LLK L + Sbjct: 95 GPNIIAMLDVVREPQSKTPGLIFEHINNIDFRSLYPTFT-DYD---IRFYMYELLKALDY 150 Query: 117 CHSRNVLHRDLKPQNLLINRNGEL-KLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFG 175 HS ++HRD+KP N++I+ + +L +L D+GLA + P Y+ V + +++ P++L Sbjct: 151 SHSMGIMHRDVKPHNVMIDHDKKLLRLIDWGLAEYYH-PGTEYNVRVASRYFKGPELLVD 209 Query: 176 AKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLP- 234 +LY S+DMWS GC+ A + P F G DQL +I R+LG+ +++ + Sbjct: 210 YRLYDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQLVQIVRVLGSKNFKKYLEKYNISL 269 Query: 235 --DYKPYPMYPAT--TSLVNVVPK--LNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286 +Y+ Y +N K ++ DL+ LL+ + +R++A+EA++H YF Sbjct: 270 GEEYEDIGYYNKRQWVRFMNENNKDLVSQEFLDLIDRLLRYDHQERLTAKEAMKHAYF 327 >4MVF-A nrPDB Length = 506 Score = 126 bits (317), Expect = 9e-30, Method: Compositional matrix adjust. Identities = 87/290 (30%), Positives = 145/290 (50%), Gaps = 38/290 (13%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62 KY EK+G+GTYG V+K ++ T+++ A+K + D + +EI ++K+L H N Sbjct: 58 KYIIDEKLGQGTYGCVYKGIDKVTNQLYAIKEEKKDRLKN--INRFFQEIEIMKKLDHPN 115 Query: 63 IVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSC--NGDLDPEIVKSFLFQLLKGLGFCHSR 120 IV+L++ +D + L+ E C ++ FDS NG + + + Q+ + + HS Sbjct: 116 IVKLYETYENDNYIYLIMELCSG--RELFDSIIENGSFTEKNAATIMKQIFSAIFYLHSL 173 Query: 121 NVLHRDLKPQNLLI---NRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAK 177 N++HRDLKP+N L N++ LK+ DFGL++ G + + T +Y P VL G Sbjct: 174 NIVHRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTG-EFTTTKAGTPYYVAPQVLDGK- 231 Query: 178 LYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYK 237 Y D+WS+G I L G P F G+ ++ LK++ + E W S++ Sbjct: 232 -YDKKCDIWSSGVIMYTLL-CGYPPFYGDTDNEVLKKVKKGEFCFYENDWGSIS------ 283 Query: 238 PYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFS 287 + ++L+ LL NP +R + EEAL HP+ + Sbjct: 284 -------------------SDAKNLITKLLTYNPNERCTIEEALNHPWIT 314 >2PVN-A nrPDB Length = 352 Score = 126 bits (317), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 88/300 (29%), Positives = 149/300 (49%), Gaps = 29/300 (9%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHE-IVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62 YE + K+G G Y VF+ N +E + + L+ +C N Sbjct: 54 YEVVRKVGRGKYSEVFEGINVNNNEKCIIKILKPVKKKKIKREIKILQNLC-----GGPN 108 Query: 63 IVRLHDVL--HSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 IV+L D++ K +L+FE+ + K D D ++ ++++LLK L +CHS+ Sbjct: 109 IVKLLDIVRDQHSKTPSLIFEYVNNTDFKVLYPTLTDYD---IRYYIYELLKALDYCHSQ 165 Query: 121 NVLHRDLKPQNLLINRN-GELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLY 179 ++HRD+KP N++I+ +L+L D+GLA F P + Y+ V + +++ P++L + Y Sbjct: 166 GIMHRDVKPHNVMIDHELRKLRLIDWGLAE-FYHPGKEYNVRVASRYFKGPELLVDLQDY 224 Query: 180 STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGT------------PTEEQW 227 S+DMWS GC+FA + P F G+D DQL +I ++LGT + Q Sbjct: 225 DYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKIAKVLGTDGLNAYLNKYRIELDPQL 284 Query: 228 PSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFS 287 ++ KP+ + + V P+ D L LL+ + +R++A EA+ HPYF Sbjct: 285 EALVGRHSRKPWLKFMNADNQHLVSPE----AIDFLDKLLRYDHQERLTALEAMTHPYFQ 340 >4LFI-A nrPDB Length = 374 Score = 124 bits (310), Expect = 7e-29, Method: Compositional matrix adjust. Identities = 76/240 (31%), Positives = 133/240 (55%), Gaps = 17/240 (7%) Query: 60 HKNIVRLHDVLHS--DKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFLFQLLKGLGF 116 H NI+ L D++ K LVFE+ D D + + DL+ ++ ++F+LLK L + Sbjct: 132 HANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPKLT-DLE---IRFYMFELLKALDY 187 Query: 117 CHSRNVLHRDLKPQNLLIN-RNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFG 175 CHS ++HRD+KP N++I+ +N +L+L D+GLA + + + Y+ V + +++ P++L Sbjct: 188 CHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNME-YNVRVASRFFKGPELLVD 246 Query: 176 AKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQW--PSMTKL 233 ++Y S+D+WS G + A + P F G DQL +I ++LGT E++ L Sbjct: 247 YRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITL 306 Query: 234 P----DYKPYPMYPATTSLVNVVPKLNATGR--DLLQNLLKCNPVQRISAEEALQHPYFS 287 P D Y P + + L+ DL+ NLL+ + +R++A+EA+ HP+F+ Sbjct: 307 PREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFA 366 >6CQF-A nrPDB Length = 297 Score = 123 bits (308), Expect = 1e-28, Method: Compositional matrix adjust. Identities = 72/202 (35%), Positives = 113/202 (55%), Gaps = 4/202 (1%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 Y+ L+++G GTYG VFKA+++ + ++VALK V+++ DD+ S+ +EI +LK +H NI Sbjct: 18 YDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDD--VSTLQKEILILKTCRHANI 75 Query: 64 VRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVL 123 V H +KL + EFC + G L + ++L+GL + HS+ + Sbjct: 76 VAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSQKKI 135 Query: 124 HRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGA--KLYST 181 HRD+K N+LIN GE++LADFG++ G + A + T ++ P+V A Y+ Sbjct: 136 HRDIKGANILINDAGEVRLADFGISAQIGATLARRLAFIGTPYWMAPEVAAVALKGGYNE 195 Query: 182 SIDMWSAGCIFAELANAGRPLF 203 D+WS G ELA PLF Sbjct: 196 LCDIWSLGITAIELAELQPPLF 217 >5XVU-A nrPDB Length = 332 Score = 122 bits (306), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 92/304 (30%), Positives = 161/304 (52%), Gaps = 31/304 (10%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 +YE ++KIG G Y VF + E + A+K ++ REI +L+ L Sbjct: 31 NRYEIMKKIGRGKYSEVFNGYDTECNRPCAIKVLK-----PVKKKKIKREIKILQNLNGG 85 Query: 62 -NIVRLHDVLHS--DKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFC 117 NI++L D++ K +L+FE+ + D K + D D ++ +++Q+LK L +C Sbjct: 86 PNIIKLLDIVKDPVTKTPSLIFEYINNIDFKTLYPKFT-DKD---IRYYIYQILKALDYC 141 Query: 118 HSRNVLHRDLKPQNLLINR-NGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGA 176 HS+ ++HRD+KP N++I+ N +++L +GLA F P + Y+ V + +Y+ P++L Sbjct: 142 HSQGIMHRDVKPHNIMIDHENRQIRLISWGLAE-FYHPGQEYNVRVASRYYKGPELLIDL 200 Query: 177 KLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKL--- 233 +LY S+D+WS GC+ A + P F G+D DQL +I ++LGT + + Sbjct: 201 QLYDYSLDIWSLGCMLAGMIFKKEPFFCGHDNYDQLVKIAKVLGTEDLHAYLKKYNIKLK 260 Query: 234 PDY---------KPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHP 284 P Y KP+ + T S +++ DL+ +L + +RI+ +EA++HP Sbjct: 261 PHYLNILGEYERKPWSHF-LTQSNIDIA---KDEVIDLIDKMLIYDHAKRIAPKEAMEHP 316 Query: 285 YFSD 288 YF + Sbjct: 317 YFRE 320 >6EII-A nrPDB Length = 352 Score = 120 bits (301), Expect = 7e-28, Method: Compositional matrix adjust. Identities = 94/302 (31%), Positives = 161/302 (53%), Gaps = 35/302 (11%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK-N 62 Y+ + K+G G Y VF+A N +E V +K ++ REI +L+ L+ N Sbjct: 62 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILK-----PVKKKKIKREIKILENLRGGPN 116 Query: 63 IVRLHDVLHSDKKLT--LVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 I+ L D++ T LVFE + D K+ + + D D ++ +++++LK L +CHS Sbjct: 117 IITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLT-DYD---IRFYMYEILKALDYCHS 172 Query: 120 RNVLHRDLKPQNLLINR-NGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL 178 ++HRD+KP N++I+ + +L+L D+GLA F P + Y+ V + +++ P++L ++ Sbjct: 173 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE-FYHPGQEYNVRVASRYFKGPELLVDYQM 231 Query: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKL----- 233 Y S+DMWS GC+ A + P F G+D DQL RI ++LG TE+ + + K Sbjct: 232 YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLG--TEDLYDYIDKYNIELD 289 Query: 234 PDY---------KPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHP 284 P + K + + + + V P+ D L LL+ + R++A EA++HP Sbjct: 290 PRFNDILGRHSRKRWERFVHSENQHLVSPE----ALDFLDKLLRYDHQSRLTAREAMEHP 345 Query: 285 YF 286 YF Sbjct: 346 YF 347 >4MD7-E nrPDB Length = 391 Score = 119 bits (298), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 94/302 (31%), Positives = 161/302 (53%), Gaps = 35/302 (11%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK-N 62 Y+ + K+G G Y VF+A N +E V +K ++ REI +L+ L+ N Sbjct: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPV-----KKKKIKREIKILENLRGGPN 93 Query: 63 IVRLHDVLHSDKKLT--LVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 I+ L D++ T LVFE + D K+ + + D D ++ +++++LK L +CHS Sbjct: 94 IITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLT-DYD---IRFYMYEILKALDYCHS 149 Query: 120 RNVLHRDLKPQNLLINR-NGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL 178 ++HRD+KP N++I+ + +L+L D+GLA F P + Y+ V + +++ P++L ++ Sbjct: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE-FYHPGQEYNVRVASRYFKGPELLVDYQM 208 Query: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKL----- 233 Y S+DMWS GC+ A + P F G+D DQL RI ++LG TE+ + + K Sbjct: 209 YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLG--TEDLYDYIDKYNIELD 266 Query: 234 PDY---------KPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHP 284 P + K + + + + V P+ D L LL+ + R++A EA++HP Sbjct: 267 PRFNDILGRHSRKRWERFVHSENQHLVSPE----ALDFLDKLLRYDHQSRLTAREAMEHP 322 Query: 285 YF 286 YF Sbjct: 323 YF 324 >4CZT-A nrPDB Length = 464 Score = 119 bits (298), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 92/294 (31%), Positives = 140/294 (47%), Gaps = 47/294 (15%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSAL-----REICLLKE 57 KYE +GEGT+ V A+N E + VA+K + D E V + + REI +K Sbjct: 12 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVI----DKEKVLKNKMIAQIKREISTMKL 67 Query: 58 LKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFD--SCNGDLDPEIVKSFLFQLLKGLG 115 +KH N++R+ +V+ S K+ V EF + FD S NG L + + + QL+ + Sbjct: 68 IKHPNVIRMFEVMASKTKIYFVLEFVTGG--ELFDKISSNGRLKEDEARKYFQQLINAVD 125 Query: 116 FCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVR---CYSAEVVTLWYRPPDV 172 +CHSR V HRDLKP+NLL++ NG LK++DFGL+ A VR T Y P+V Sbjct: 126 YCHSRGVYHRDLKPENLLLDANGALKVSDFGLS-ALPQQVREDGLLHTTCGTPNYVAPEV 184 Query: 173 LFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTK 232 + D+WS G I L AG F +++ K+IF+ E P Sbjct: 185 INNKGYDGAKADLWSCGVILFVLM-AGYLPFEDSNLTSLYKKIFK-----AEFTCP---- 234 Query: 233 LPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286 P +A+ + L++ +L NP RI+ E +++ +F Sbjct: 235 --------------------PWFSASAKKLIKRILDPNPATRITFAEVIENEWF 268 >4B8L-A nrPDB Length = 286 Score = 119 bits (298), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 85/282 (30%), Positives = 140/282 (49%), Gaps = 44/282 (15%) Query: 10 IGEGTYGTVFKAKNRETHEIVALKRV-RLDDDDEGVPSSALREICLLKELKHKNIVRLHD 68 +G+G +G V+ A+ ++ I+ALK + + + EGV REI + L+H NI+R+++ Sbjct: 23 LGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRREIEIQSHLRHPNILRMYN 82 Query: 69 VLHSDKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDL 127 H K++ L+ EF + +L K +G D + +F+ +L L +CH R V+HRD+ Sbjct: 83 YFHDRKRIYLMLEFAPRGELYKELQK-HGRFDEQRSATFMEELADALHYCHERKVIHRDI 141 Query: 128 KPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWS 187 KP+NLL+ GELK+ADFG + P TL Y PP+++ G K + +D+W Sbjct: 142 KPENLLMGYKGELKIADFGW--SVHAPSLRRRTMCGTLDYLPPEMIEG-KTHDEKVDLWC 198 Query: 188 AGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTS 247 AG + E L+G P + PS T+ Sbjct: 199 AGVLCYEF----------------------LVGMPPFDS-PSHTE-----------THRR 224 Query: 248 LVNV----VPKLNATGRDLLQNLLKCNPVQRISAEEALQHPY 285 +VNV P L+ +DL+ LL+ +P QR+ + ++HP+ Sbjct: 225 IVNVDLKFPPFLSDGSKDLISKLLRYHPPQRLPLKGVMEHPW 266 >5Y86-A nrPDB Length = 588 Score = 119 bits (297), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 95/333 (28%), Positives = 156/333 (46%), Gaps = 57/333 (17%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62 +YE L+ IG+G++G V + + + + VALK VR +++ A EI +L+ LK ++ Sbjct: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVR---NEKRFHRQAAEEIRILEHLKKQD 264 Query: 63 IVRLHDVLHSDKKLT------LVFEFCDQDLKKYFDSCN-GDLDPEIVKSFLFQLLKGLG 115 +V+H + T + FE DL + ++V+ F +L+ L Sbjct: 265 KTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLD 324 Query: 116 FCHSRNVLHRDLKPQNLLINRNG--ELKLADFGLARAFGIPVRCYSAE-----VVTLWYR 168 H ++H DLKP+N+L+ +G K+ DFG + C+ + + + +YR Sbjct: 325 ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSS--------CFEYQKLYTYIQSRFYR 376 Query: 169 PPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTE---E 225 P+++ G++ YST ID+WS GCI AEL G+PLFPG D DQL + LLG P E Sbjct: 377 APEIILGSR-YSTPIDIWSFGCILAELL-TGQPLFPGEDEGDQLACMMELLGMPPPKLLE 434 Query: 226 QWPSMTKLPDYKPYPMYPATTSL----VNVVPKLNATGR--------------------- 260 Q + K P Y + T+ V +V + G+ Sbjct: 435 QSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYL 494 Query: 261 --DLLQNLLKCNPVQRISAEEALQHPYFSDFCP 291 + L+ L +P R++ +AL+HP+ S P Sbjct: 495 FIEFLKRCLHWDPSARLTPAQALRHPWISKSVP 527 >3LIJ-A nrPDB Length = 494 Score = 118 bits (296), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 85/301 (28%), Positives = 143/301 (47%), Gaps = 52/301 (17%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 Y++++K+G G YG V +++ TH A+K +R S L E+ +LK L H NI Sbjct: 39 YQRVKKLGSGAYGEVLLCRDKVTHVERAIKIIRKTSVSTSSNSKLLEEVAVLKLLDHPNI 98 Query: 64 VRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLF----------QLLKG 113 ++L+D + LV E C + G+L EI+ F Q+L G Sbjct: 99 MKLYDFFEDKRNYYLVME-CYK---------GGELFDEIIHRMKFNEVDAAVIIKQVLSG 148 Query: 114 LGFCHSRNVLHRDLKPQNLLI---NRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPP 170 + + H N++HRDLKP+NLL+ ++ +K+ DFGL+ F + + T +Y P Sbjct: 149 VTYLHKHNIVHRDLKPENLLLESKEKDALIKIVDFGLSAVFENQKKM-KERLGTAYYIAP 207 Query: 171 DVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSM 230 +VL K Y D+WS G I L AG P F G + L+++ + T +W ++ Sbjct: 208 EVL--RKKYDEKCDVWSIGVILFILL-AGYPPFGGQTDQEILRKVEKGKYTFDSPEWKNV 264 Query: 231 TKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFC 290 ++ +DL++ +L+ + +RISA++AL+HP+ + C Sbjct: 265 SE-------------------------GAKDLIKQMLQFDSQRRISAQQALEHPWIKEMC 299 Query: 291 P 291 Sbjct: 300 S 300 >3DFA-A nrPDB Length = 286 Score = 116 bits (291), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 85/301 (28%), Positives = 142/301 (47%), Gaps = 52/301 (17%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 ++Y + +G+G++G V K K+R T + A+K + S+ LRE+ LLK+L H Sbjct: 22 ERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKLDHP 81 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLF----------QLL 111 NI++L ++L +V E G+L EI+K F Q+ Sbjct: 82 NIMKLFEILEDSSSFYIVGEL----------YTGGELFDEIIKRKRFSEHDAARIIKQVF 131 Query: 112 KGLGFCHSRNVLHRDLKPQNLLI---NRNGELKLADFGLARAFGIPVRCYSAEVVTLWYR 168 G+ + H N++HRDLKP+N+L+ ++ ++K+ DFGL+ F + + T +Y Sbjct: 132 SGITYMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKM-KDRIGTAYYI 190 Query: 169 PPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWP 228 P+VL G Y D+WSAG I L +G P F G + D LKR+ E Sbjct: 191 APEVLRGT--YDEKCDVWSAGVILYILL-SGTPPFYGKNEYDILKRV---------ETGK 238 Query: 229 SMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288 LP ++ ++ +DL++ +L +P RI+A + L+HP+ Sbjct: 239 YAFDLPQWRT----------------ISDDAKDLIRKMLTFHPSLRITATQCLEHPWIQK 282 Query: 289 F 289 + Sbjct: 283 Y 283 >3NCG-A nrPDB Length = 486 Score = 115 bits (289), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 85/303 (28%), Positives = 142/303 (46%), Gaps = 52/303 (17%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 ++Y + +G+G++G V K K+R T + A+K + S+ LRE+ LLK+L H Sbjct: 22 ERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKLDHP 81 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLF----------QLL 111 NI++L ++L +V E G+L EI+K F Q+ Sbjct: 82 NIMKLFEILEDSSSFYIVGELY----------TGGELFDEIIKRKRFSEHDAARIIKQVF 131 Query: 112 KGLGFCHSRNVLHRDLKPQNLLI---NRNGELKLADFGLARAFGIPVRCYSAEVVTLWYR 168 G+ + H N++HRDLKP+N+L+ ++ ++K+ DFGL+ F + + T +Y Sbjct: 132 SGITYMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKM-KDRIGTAYYI 190 Query: 169 PPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWP 228 P+VL G Y D+WSAG I L +G P F G + D LKR+ E Sbjct: 191 APEVLRGT--YDEKCDVWSAGVILYILL-SGTPPFYGKNEYDILKRV---------ETGK 238 Query: 229 SMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288 LP ++ ++ +DL++ +L +P RI+A + L+HP+ Sbjct: 239 YAFDLPQWRT----------------ISDDAKDLIRKMLTFHPSLRITATQCLEHPWIQK 282 Query: 289 FCP 291 + Sbjct: 283 YSS 285 >6FDY-U nrPDB Length = 276 Score = 114 bits (286), Expect = 4e-26, Method: Compositional matrix adjust. Identities = 87/281 (30%), Positives = 133/281 (47%), Gaps = 32/281 (11%) Query: 8 EKIGEGTYGTVFKA-KNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRL 66 E++G GTY TV+KA ++T E+VA+K V ++ + L EI +LK ++H +IV+L Sbjct: 17 ERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKGIRHPHIVQL 76 Query: 67 HDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRD 126 D + L+ EFC F L ++ + F+ QL L F H RN+ H D Sbjct: 77 KDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFLHERNISHLD 136 Query: 127 LKPQNLLIN--RNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSID 184 LKPQN+L++ LKLADFG A+ + L+ P V + Y +D Sbjct: 137 LKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMVC--QRQYDARVD 194 Query: 185 MWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPA 244 +WS G I E A G+P F + ++I + + +LP Sbjct: 195 LWSMGVILYE-ALFGQPPFASRSFSELEEKI----------RSNRVIELP---------- 233 Query: 245 TTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPY 285 + P L+ RDLLQ LL+ +P +RIS ++ HP+ Sbjct: 234 ------LRPLLSRDCRDLLQRLLERDPSRRISFQDFFAHPW 268 >3DXN-A nrPDB Length = 287 Score = 114 bits (284), Expect = 6e-26, Method: Compositional matrix adjust. Identities = 88/299 (29%), Positives = 145/299 (48%), Gaps = 47/299 (15%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSAL-REICLLKELKHK 61 +Y++++K+G G YG V K++ T A+K ++ S AL E+ +LK+L H Sbjct: 22 RYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDHP 81 Query: 62 NIVRLHDVLHSDKKLTLVFE-------FCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGL 114 NI++L++ + LV E F + L++ F ++D ++ + Q+L G Sbjct: 82 NIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILRQKFS----EVDAAVI---MKQVLSGT 134 Query: 115 GFCHSRNVLHRDLKPQNLLI---NRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPD 171 + H N++HRDLKP+NLL+ +R+ +K+ DFGL+ F + + + T +Y P+ Sbjct: 135 TYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKM-KERLGTAYYIAPE 193 Query: 172 VLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMT 231 VL K Y D+WS G I L G P F G + LKR+ E+ Sbjct: 194 VL--RKKYDEKCDVWSCGVILYILL-CGYPPFGGQTDQEILKRV---------EKGKFSF 241 Query: 232 KLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFC 290 PD+ +++ + L++ +L P +RISAEEAL HP+ FC Sbjct: 242 DPPDW----------------TQVSDEAKQLVKLMLTYEPSKRISAEEALNHPWIVKFC 284 >3HZT-A nrPDB Length = 467 Score = 112 bits (280), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 88/300 (29%), Positives = 145/300 (48%), Gaps = 47/300 (15%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSAL-REICLLKELKHK 61 +Y++++K+G G YG V K++ T A+K ++ S AL E+ +LK+L H Sbjct: 5 RYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDHP 64 Query: 62 NIVRLHDVLHSDKKLTLVFE-------FCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGL 114 NI++L++ + LV E F + L++ F ++D ++ + Q+L G Sbjct: 65 NIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILRQKF----SEVDAAVI---MKQVLSGT 117 Query: 115 GFCHSRNVLHRDLKPQNLLI---NRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPD 171 + H N++HRDLKP+NLL+ +R+ +K+ DFGL+ F + + + T +Y P+ Sbjct: 118 TYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKM-KERLGTAYYIAPE 176 Query: 172 VLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMT 231 VL K Y D+WS G I L G P F G + LKR+ E+ Sbjct: 177 VL--RKKYDEKCDVWSCGVILYILL-CGYPPFGGQTDQEILKRV---------EKGKFSF 224 Query: 232 KLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCP 291 PD+ +++ + L++ +L P +RISAEEAL HP+ FC Sbjct: 225 DPPDW----------------TQVSDEAKQLVKLMLTYEPSKRISAEEALNHPWIVKFCS 268 >4D28-A nrPDB Length = 446 Score = 112 bits (279), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 73/200 (36%), Positives = 107/200 (53%), Gaps = 19/200 (9%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALK--------RVRLDDDDEGVPSSALREICL 54 KYE IGEGT+ V A+N +T + VA+K + R+ D + REI + Sbjct: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIK-------REISI 62 Query: 55 LKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSC--NGDLDPEIVKSFLFQLLK 112 +K ++H NIVRL++VL S K+ +V EF + FD G L + + + QL+ Sbjct: 63 MKIVRHPNIVRLYEVLASKSKIYIVLEFVTGG--ELFDRIVHKGRLKEDESRKYFQQLVD 120 Query: 113 GLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDV 172 + CHS+ V HRDLKP+NLL++ NG LK++DFGL+ V + T Y P+V Sbjct: 121 AVAHCHSKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLNDTCGTPNYVAPEV 180 Query: 173 LFGAKLYSTSIDMWSAGCIF 192 L G ++ D+WS G I Sbjct: 181 LSGQGYDGSAADIWSCGVIL 200 >4APC-A nrPDB Length = 350 Score = 111 bits (278), Expect = 3e-25, Method: Compositional matrix adjust. Identities = 61/197 (30%), Positives = 103/197 (52%), Gaps = 3/197 (1%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 M+KY +L+KIGEG++G K+ E +K + + + RE+ +L +KH Sbjct: 23 MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKH 82 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCD-QDLKKYFDSCNGDLDPE-IVKSFLFQLLKGLGFCH 118 NIV+ + + L +V ++C+ DL K ++ G L E + + Q+ L H Sbjct: 83 PNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVH 142 Query: 119 SRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL 178 R +LHRD+K QN+ + ++G ++L DFG+AR V A + T +Y P++ K Sbjct: 143 DRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARACIGTPYYLSPEICEN-KP 201 Query: 179 YSTSIDMWSAGCIFAEL 195 Y+ D+W+ GC+ EL Sbjct: 202 YNNKSDIWALGCVLYEL 218 >5YKS-A nrPDB Length = 377 Score = 110 bits (276), Expect = 5e-25, Method: Compositional matrix adjust. Identities = 77/290 (26%), Positives = 135/290 (46%), Gaps = 33/290 (11%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 Y+ + +G G + V A++ T E VA+K + D +E+ +K ++H NI Sbjct: 37 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHPNI 96 Query: 64 VRLHDVLHSDKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNV 122 VRL++V+ + KL L+ E D D+ Y L+ ++ K + Q++ + +CH +V Sbjct: 97 VRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLHV 156 Query: 123 LHRDLKPQNLLI-NRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYST 181 +HRDLKP+N++ + G +KL DFG + F P + + +L Y P++L G + + Sbjct: 157 VHRDLKPENVVFFEKQGLVKLTDFGFSNKFQ-PGKKLTTSCGSLAYSAPEILLGDEYDAP 215 Query: 182 SIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPM 241 ++D+WS G I L P ND + ++T + D K Sbjct: 216 AVDIWSLGVILFMLVCGQPPFQEANDSE-------------------TLTMIMDCK---- 252 Query: 242 YPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCP 291 V ++ +DL+ +L+ +P +R S EE HP+ P Sbjct: 253 -------YTVPSHVSKECKDLITRMLQRDPKRRASLEEIENHPWLQGVDP 295 >5J5T-A nrPDB Length = 370 Score = 109 bits (272), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 83/288 (28%), Positives = 137/288 (47%), Gaps = 29/288 (10%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 + +E +++IG GTYG V+KA+N T E+ A+K ++L+ ++ + +EI ++K+ KH Sbjct: 4 EDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDF--AVVQQEIIMMKDCKHP 61 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN 121 NIV KL + EFC + G L + + L+GL + HS+ Sbjct: 62 NIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSKG 121 Query: 122 VLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL--Y 179 +HRD+K N+L+ NG +KLADFG++ + A + T ++ P+V + Y Sbjct: 122 KMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKAFIGTPYWMAPEVAAVERKGGY 181 Query: 180 STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPY 239 + D+W+ G ELA P+F D R L+ T + Q P KL D Sbjct: 182 NQLCDLWAVGITAIELAELQPPMF-----DLHPMRALFLM-TKSNFQPP---KLKDKM-- 230 Query: 240 PMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFS 287 K + + ++ L NP +R +AE+ LQHP+ + Sbjct: 231 --------------KWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVT 264 >4JXF-A nrPDB Length = 266 Score = 108 bits (270), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 76/280 (27%), Positives = 131/280 (46%), Gaps = 33/280 (11%) Query: 10 IGEGTYGTVFKAKNRETHEIVALKRV-RLDDDDEGVPSSALREICLLKELKHKNIVRLHD 68 +G+G++ V++A++ T VA+K + + G+ E+ + +LKH +I+ L++ Sbjct: 15 LGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSILELYN 74 Query: 69 VLHSDKKLTLVFEFC-DQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDL 127 + LV E C + ++ +Y + + F+ Q++ G+ + HS +LHRDL Sbjct: 75 YFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHSHGILHRDL 134 Query: 128 KPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWS 187 NLL+ RN +K+ADFGLA +P + T Y P++ + + D+WS Sbjct: 135 TLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSA-HGLESDVWS 193 Query: 188 AGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTS 247 GC+F L GRP F + V + L ++ L DY+ P + Sbjct: 194 LGCMFYTLL-IGRPPFDTDTVKNTLNKVV----------------LADYE-MPSF----- 230 Query: 248 LVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFS 287 L+ +DL+ LL+ NP R+S L HP+ S Sbjct: 231 -------LSIEAKDLIHQLLRRNPADRLSLSSVLDHPFMS 263 >3COM-A nrPDB Length = 314 Score = 108 bits (269), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 77/283 (27%), Positives = 141/283 (49%), Gaps = 33/283 (11%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 ++ LEK+GEG+YG+V+KA ++ET +IVA+K+V ++ D + + ++EI ++++ ++ Sbjct: 31 FDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEI----IKEISIMQQCDSPHV 86 Query: 64 VRLHDVLHSDKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNV 122 V+ + + L +V E+C + N L + + + L LKGL + H Sbjct: 87 VKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRK 146 Query: 123 LHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTS 182 +HRD+K N+L+N G KLADFG+A + + + T ++ P+V+ Y+ Sbjct: 147 IHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIG-YNCV 205 Query: 183 IDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMY 242 D+WS G E+A G+P P D+ ++ IF + P P ++ ++ Sbjct: 206 ADIWSLGITAIEMAE-GKP--PYADIHP-MRAIFMIPTNPP----------PTFRKPELW 251 Query: 243 PATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPY 285 + D ++ L +P QR +A + LQHP+ Sbjct: 252 SDNFT-------------DFVKQCLVKSPEQRATATQLLQHPF 281 >4RGJ-A nrPDB Length = 520 Score = 107 bits (267), Expect = 6e-24, Method: Compositional matrix adjust. Identities = 89/304 (29%), Positives = 146/304 (48%), Gaps = 62/304 (20%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRET-HE----IVALKRVRLDDDDEGVPSSALREICLLK 56 ++Y+ ++ +G+G++G V ++++ T HE +++ K V+ D E S LRE+ LLK Sbjct: 60 EQYKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKE----SLLREVELLK 115 Query: 57 ELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLF-------- 108 L H NI++L++ + LV + G+L EI+ F Sbjct: 116 MLDHINIMKLYEFFEDNNYYYLVSDVY----------TGGELFDEIISRKRFYEIDAARI 165 Query: 109 --QLLKGLGFCHSRNVLHRDLKPQNLLI-NRNGE---LKLADFGLARAFGIPVRCYSAEV 162 Q+L G+ + H NV+HRDLKP+N+L+ +N E +K+ DFGL+ F + ++ Sbjct: 166 IKQILSGITYMHKNNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHFEYSKKM-KDKI 224 Query: 163 VTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTP 222 T +Y PDVL G Y D+WS G I L +G P F G++ D LK++ Sbjct: 225 GTAYYIAPDVLHGT--YDEKCDIWSCGVILYILL-SGCPPFNGSNEYDILKKV------- 274 Query: 223 TEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQ 282 E LP +K K++ +DL++ +L RISA +AL+ Sbjct: 275 --EAGKYTFDLPQFK----------------KISDKAKDLIKKMLMYTSAVRISARDALE 316 Query: 283 HPYF 286 H + Sbjct: 317 HEWI 320 >4LG4-A nrPDB Length = 299 Score = 107 bits (266), Expect = 8e-24, Method: Compositional matrix adjust. Identities = 80/290 (27%), Positives = 143/290 (49%), Gaps = 35/290 (12%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 ++ LEK+GEG+YG+VFKA ++E+ ++VA+K+V ++ D + + ++EI ++++ + Sbjct: 13 FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEI----IKEISIMQQCDSPYV 68 Query: 64 VRLHDVLHSDKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNV 122 V+ + + L +V E+C + N L + + + L LKGL + H Sbjct: 69 VKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRK 128 Query: 123 LHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTS 182 +HR++K N+L+N G KLADFG+A + + + T ++ P+V+ Y+ Sbjct: 129 IHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIG-YNCV 187 Query: 183 IDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMY 242 D+WS G E+A G+P P D+ ++ IF + P P+ K Sbjct: 188 ADIWSLGITSIEMAE-GKP--PYADIHP-MRAIFMIPTNPP----PTFRK---------- 229 Query: 243 PATTSLVNVVPKLNATG-RDLLQNLLKCNPVQRISAEEALQHPYFSDFCP 291 P+L + D ++ L NP QR +A + LQHP+ + P Sbjct: 230 ----------PELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKP 269 >6AO5-A nrPDB Length = 362 Score = 106 bits (265), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 77/289 (26%), Positives = 142/289 (49%), Gaps = 33/289 (11%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 ++ LEK+GEG+YG+VFKA ++E+ ++VA+K+V ++ D + + ++EI ++++ + Sbjct: 12 FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEI----IKEISIMQQCDSPYV 67 Query: 64 VRLHDVLHSDKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNV 122 V+ + + L +V E+C + N L + + + L LKGL + H Sbjct: 68 VKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRK 127 Query: 123 LHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTS 182 +HR++K N+L+N G KLADFG+A + + + T ++ P+V+ Y+ Sbjct: 128 IHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIG-YNCV 186 Query: 183 IDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMY 242 D+WS G E+A G+P P D+ ++ IF + P P ++ ++ Sbjct: 187 ADIWSLGITSIEMAE-GKP--PYADIHP-MRAIFMIPTNPP----------PTFRKPELW 232 Query: 243 PATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCP 291 + D ++ L NP QR +A + LQHP+ + P Sbjct: 233 SDDFT-------------DFVKKCLVKNPEQRATATQLLQHPFIKNAKP 268 >2WO6-A nrPDB Length = 382 Score = 106 bits (264), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 102/337 (30%), Positives = 153/337 (45%), Gaps = 64/337 (18%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 M +YE IG+G++G V KA +R E VA+K ++ + + + A E+ LL EL + Sbjct: 53 MDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIK---NKKAFLNQAQIEVRLL-ELMN 108 Query: 61 KN-------IVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCN-GDLDPEIVKSFLFQLLK 112 K+ IV L L LVFE +L + N + + + F Q+ Sbjct: 109 KHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCT 168 Query: 113 GLGFCHS--RNVLHRDLKPQNLLI--NRNGELKLADFGLARAFGIPVRCYSAEVVTLWYR 168 L F + +++H DLKP+N+L+ + +K+ DFG + G + Y + + +YR Sbjct: 169 ALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQY---IQSRFYR 225 Query: 169 PPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTE---E 225 P+VL G Y +IDMWS GCI E+ + G PLF G + DQ+ +I +LG P + Sbjct: 226 SPEVLLGMP-YDLAIDMWSLGCILVEM-HTGEPLFSGANEVDQMNKIVEVLGIPPAHILD 283 Query: 226 QWPS----MTKLPD--------------YKPYPMYPATTSLVNVV------PKLNATG-- 259 Q P KLPD YKP P T L N++ P G Sbjct: 284 QAPKARKFFEKLPDGTWNLKKTKDGKREYKP----PGTRKLHNILGVETGGPGGRRAGES 339 Query: 260 ----------RDLLQNLLKCNPVQRISAEEALQHPYF 286 +DL+ +L +P RI ALQH +F Sbjct: 340 GHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFF 376 >2WQN-A nrPDB Length = 310 Score = 106 bits (264), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 71/254 (27%), Positives = 115/254 (45%), Gaps = 27/254 (10%) Query: 8 EKIGEGTYGTVFKAKNRETHEIVALKRVRLDD-DDEGVPSSALREICLLKELKHKNIVRL 66 +KIG G + V++A VALK+V++ D D + ++EI LLK+L H N+++ Sbjct: 38 KKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHPNVIKY 97 Query: 67 HDVLHSDKKLTLVFEFCD----QDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNV 122 + D +L +V E D + K+F + V + QL L HSR V Sbjct: 98 YASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHMHSRRV 157 Query: 123 LHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTS 182 +HRD+KP N+ I G +KL D GL R F + V T +Y P+ + Y+ Sbjct: 158 MHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIH-ENGYNFK 216 Query: 183 IDMWSAGCIFAELANAGRPLF---------------------PGNDVDDQLKRIFRLLGT 221 D+WS GC+ E+A P + P + ++L+++ + Sbjct: 217 SDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQLVNMCIN 276 Query: 222 PTEEQWPSMTKLPD 235 P E+ P +T + D Sbjct: 277 PDPEKRPDVTYVYD 290 >5WAX-A nrPDB Length = 310 Score = 105 bits (263), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 79/287 (27%), Positives = 132/287 (45%), Gaps = 32/287 (11%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62 +YE + IG G +G +NR ++VA+K + + E + + REI + L+H N Sbjct: 12 RYELVRDIGSGNFGVARLMRNRADGQLVAVKYI---ERGEKIDENVQREIINHRSLRHPN 68 Query: 63 IVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCN-GDLDPEIVKSFLFQLLKGLGFCHSRN 121 I+R +V+ + L +V E+ + + CN G + + F QL+ G+ +CHS Sbjct: 69 IIRFKEVILTPTHLAIVMEYASGG-ELFERICNAGRFSEDEARFFFQQLISGVSYCHSMQ 127 Query: 122 VLHRDLKPQNLLINRNG--ELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLY 179 V HRDLK +N L++ + LK+ DFG +++ + + S V T Y P+VL + Sbjct: 128 VCHRDLKLENTLLDGSTAPRLKICDFGYSKSSVLHSQPKST-VGTPAYIAPEVLLKKEYD 186 Query: 180 STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPY 239 D+WS G + P ++ + K I R+LG +PDY Sbjct: 187 GKVADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRILGV--------QYSIPDY--- 235 Query: 240 PMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286 V++ P+ +DL+ + NP RI+ E HP+F Sbjct: 236 ---------VHISPEC----QDLISRIFVANPATRITIPEIRNHPWF 269 >3MA6-A nrPDB Length = 298 Score = 105 bits (262), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 84/306 (27%), Positives = 144/306 (47%), Gaps = 61/306 (19%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHE-----IVALKRVRLDDDDEGVPSSALREICLLKE 57 +Y+ +G+G++G V K++ T + +++ ++V+ D E S LRE+ LLK+ Sbjct: 33 RYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKE----SLLREVQLLKQ 88 Query: 58 LKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLF--------- 108 L H NI++L++ LV E G+L EI+ F Sbjct: 89 LDHPNIMKLYEFFEDKGYFYLVGEVY----------TGGELFDEIISRKRFSEVDAARII 138 Query: 109 -QLLKGLGFCHSRNVLHRDLKPQNLLI---NRNGELKLADFGLARAFGIPVRCYSAEVVT 164 Q+L G+ + H ++HRDLKP+NLL+ +++ +++ DFGL+ F + ++ T Sbjct: 139 RQVLSGITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKM-KDKIGT 197 Query: 165 LWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTE 224 +Y P+VL G Y D+WS G I L +G P F G + D LK++ Sbjct: 198 AYYIAPEVLHGT--YDEKCDVWSTGVILYILL-SGCPPFNGANEYDILKKV--------- 245 Query: 225 EQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHP 284 E+ +LP +K K++ + +DL++ +L P RISA +AL H Sbjct: 246 EKGKYTFELPQWK----------------KVSESAKDLIRKMLTYVPSMRISARDALDHE 289 Query: 285 YFSDFC 290 + + Sbjct: 290 WIQTYT 295 >5JN2-A nrPDB Length = 525 Score = 104 bits (260), Expect = 3e-23, Method: Compositional matrix adjust. Identities = 84/306 (27%), Positives = 144/306 (47%), Gaps = 61/306 (19%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHE-----IVALKRVRLDDDDEGVPSSALREICLLKE 57 +Y+ +G+G++G V K++ T + +++ ++V+ D E S LRE+ LLK+ Sbjct: 68 RYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKE----SLLREVQLLKQ 123 Query: 58 LKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLF--------- 108 L H NI++L++ LV E G+L EI+ F Sbjct: 124 LDHPNIMKLYEFFEDKGYFYLVGEVY----------TGGELFDEIISRKRFSEVDAARII 173 Query: 109 -QLLKGLGFCHSRNVLHRDLKPQNLLI---NRNGELKLADFGLARAFGIPVRCYSAEVVT 164 Q+L G+ + H ++HRDLKP+NLL+ +++ +++ DFGL+ F + ++ T Sbjct: 174 RQVLSGITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKM-KDKIGT 232 Query: 165 LWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTE 224 +Y P+VL G Y D+WS G I L +G P F G + D LK++ Sbjct: 233 AYYIAPEVLHGT--YDEKCDVWSTGVILYILL-SGCPPFNGANEYDILKKV--------- 280 Query: 225 EQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHP 284 E+ +LP +K K++ + +DL++ +L P RISA +AL H Sbjct: 281 EKGKYTFELPQWK----------------KVSESAKDLIRKMLTYVPSMRISARDALDHE 324 Query: 285 YFSDFC 290 + + Sbjct: 325 WIQTYT 330 >4YNZ-A nrPDB Length = 342 Score = 104 bits (260), Expect = 4e-23, Method: Compositional matrix adjust. Identities = 80/266 (30%), Positives = 130/266 (48%), Gaps = 22/266 (8%) Query: 6 KLEK-IGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIV 64 +LEK +G+G G V + T + VA+K V + E V REI +LK ++H +++ Sbjct: 13 RLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHVL 72 Query: 65 RLHDVLHSDKKLTLVFEFCDQDLKKYFDSC--NGDLDPEIVKSFLFQLLKGLGFCHSRNV 122 +LHDV + K L LV E + FD G L P+ + F Q++ L FCHS ++ Sbjct: 73 KLHDVYENKKYLYLVLEHVSGG--ELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSI 130 Query: 123 LHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTS 182 HRDLKP+NLL++ +++ADFG+A + + + Y P+V+ G K Sbjct: 131 CHRDLKPENLLLDERNNIRIADFGMA-SLQVGDSLLETSCGSPHYACPEVIRGEKYDGRK 189 Query: 183 IDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMY 242 D+WS G I L P DD L+++ E+ + +P + P Sbjct: 190 ADVWSCGVILFALLVGALPFD-----DDNLRQLL-------EKVKRGVFHMPHFIP---- 233 Query: 243 PATTSLVNVVPKLNATGRDLLQNLLK 268 P SL+ + +++A R L+++ K Sbjct: 234 PDCQSLLRGMIEVDAARRLTLEHIQK 259 >4AF3-A nrPDB Length = 292 Score = 104 bits (259), Expect = 5e-23, Method: Compositional matrix adjust. Identities = 82/279 (29%), Positives = 141/279 (50%), Gaps = 38/279 (13%) Query: 10 IGEGTYGTVFKAKNRETHEIVALKRV-RLDDDDEGVPSSALREICLLKELKHKNIVRLHD 68 +G+G +G V+ A+ +++H IVALK + + + EGV REI + L H NI+RL++ Sbjct: 31 LGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYN 90 Query: 69 VLHSDKKLTLVFEFCDQD--LKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRD 126 + +++ L+ E+ + K+ SC D + + + +L L +CH + V+HRD Sbjct: 91 YFYDRRRIYLILEYAPRGELYKELQKSCT--FDEQRTATIMEELADALMYCHGKKVIHRD 148 Query: 127 LKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMW 186 +KP+NLL+ GELK+ADFG + P TL Y PP+++ G ++++ +D+W Sbjct: 149 IKPENLLLGLKGELKIADFGW--SVHAPSLRRKTMCGTLDYLPPEMIEG-RMHNEKVDLW 205 Query: 187 SAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATT 246 G + EL G P F ++ +RI ++ D K +PA+ Sbjct: 206 CIGVLCYELL-VGNPPFESASHNETYRRIVKV----------------DLK----FPAS- 243 Query: 247 SLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPY 285 VP +DL+ LL+ NP +R+ + HP+ Sbjct: 244 -----VP---TGAQDLISKLLRHNPSERLPLAQVSAHPW 274 >5ES1-A nrPDB Length = 328 Score = 104 bits (259), Expect = 6e-23, Method: Compositional matrix adjust. Identities = 66/221 (29%), Positives = 114/221 (51%), Gaps = 16/221 (7%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSA---LREICLLKELKH 60 Y L IG+G + V A++ T VA+K + D + PSS RE+ ++K L H Sbjct: 17 YRLLRTIGKGNFAKVKLARHILTGREVAIKII---DKTQLNPSSLQKLFREVRIMKGLNH 73 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 NIV+L +V+ ++K L LV E+ + +G + + ++ Q++ + +CH + Sbjct: 74 PNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQK 133 Query: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVR----CYSAEVVTLWYRPPDVLFGA 176 N++HRDLK +NLL++ +K+ADFG + F + + C S Y P++ G Sbjct: 134 NIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPP-----YAAPELFQGK 188 Query: 177 KLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFR 217 K +D+WS G I L + P F G+++ + +R+ R Sbjct: 189 KYDGPEVDIWSLGVILYTLVSGSLP-FDGHNLKELRERVLR 228 >3MN3-A nrPDB Length = 271 Score = 103 bits (257), Expect = 8e-23, Method: Compositional matrix adjust. Identities = 81/292 (27%), Positives = 136/292 (46%), Gaps = 49/292 (16%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALK----RVRLDDDDEGVPSSALREICLLKELK 59 Y+ ++ +GEG++G V A + T + VALK +V D +G REI L+ L+ Sbjct: 6 YQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQG---RIEREISYLRLLR 62 Query: 60 HKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 H +I++L+DV+ S ++ +V E+ +L Y + + E + F Q++ + +CH Sbjct: 63 HPHIIKLYDVIKSKDEIIMVIEYAGNELFDYIVQRDKMSEQE-ARRFFQQIISAVEYCHR 121 Query: 120 RNVLHRDLKPQNLLINRNGELKLADFGLARAFG----IPVRCYSAEVVTLWYRPPDVLFG 175 ++HRDLKP+NLL++ + +K+ADFGL+ + C S Y P+V+ G Sbjct: 122 HKIVHRDLKPENLLLDEHLNVKIADFGLSNIMTDGNFLKTSCGSPN-----YAAPEVISG 176 Query: 176 AKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPD 235 +D+WS G I + P DD E P + K Sbjct: 177 KLYAGPEVDVWSCGVILYVMLCRRLPF------DD--------------ESIPVLFK--- 213 Query: 236 YKPYPMYPATTSLVNVVPKLNATG-RDLLQNLLKCNPVQRISAEEALQHPYF 286 ++ V +PK + G L++ +L NP+ RIS E +Q +F Sbjct: 214 --------NISNGVYTLPKFLSPGAAGLIKRMLIVNPLNRISIHEIMQDDWF 257 >5XZW-A nrPDB Length = 471 Score = 103 bits (257), Expect = 9e-23, Method: Compositional matrix adjust. Identities = 81/300 (27%), Positives = 140/300 (46%), Gaps = 52/300 (17%) Query: 8 EKIGEGTYGTVFKAKNRETHEIVALKRV---RLDDDDEGVPSSALREICLLKELKHKNIV 64 E +G+G + TV KA R T + A+K + ++ + +GV RE+ +L++L H IV Sbjct: 202 EVVGQGAFATVKKAIERTTGKTFAVKIISKRKVIGNMDGVT----RELEVLQKLNHPRIV 257 Query: 65 RLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLH 124 RL + +V EF F + +G + + + Q+L + + HS + H Sbjct: 258 RLKGFYEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSMGISH 317 Query: 125 RDLKPQNLLINRNGE--LKLADFGLARAFGIP--VRCYSAEVVTLWYRPPDVLFGAKL-- 178 RDLKP N+LI ++ +K+ DFGLA+ G ++ + TL Y P+V+ G Sbjct: 318 RDLKPDNILIEQDDPVLVKITDFGLAKVQGNGSFMKTFCG---TLAYVAPEVIRGKDTSV 374 Query: 179 ----------YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWP 228 YS+ +DMWS GC+ + P F G+ D ++++ +G + + P Sbjct: 375 SPDEYEERNEYSSLVDMWSMGCLVYVILTGHLP-FSGSTQD----QLYKQIGRGSYHEGP 429 Query: 229 SMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288 L D+ +++ RD + +LL+ +P R +A +AL HP+ D Sbjct: 430 ----LKDF-----------------RISEEARDFIDSLLQVDPNNRSTAAKALNHPWIVD 468 >3H4J-B nrPDB Length = 336 Score = 103 bits (257), Expect = 9e-23, Method: Compositional matrix adjust. Identities = 81/292 (27%), Positives = 139/292 (47%), Gaps = 47/292 (16%) Query: 8 EKIGEGTYGTVFKAKNRETHEIVALK---RVRLDDDDEGVPSSALREICLLKELKHKNIV 64 E +GEG++G V A + +T + VALK R L D + REI LK L+H +I+ Sbjct: 15 ETLGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSD--MHMRVEREISYLKLLRHPHII 72 Query: 65 RLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLH 124 +L+DV+ + + +V E+ +L Y + E + F Q++ + +CH ++H Sbjct: 73 KLYDVITTPTDIVMVIEYAGGELFDYIVEKKRMTEDE-GRRFFQQIICAIEYCHRHKIVH 131 Query: 125 RDLKPQNLLINRNGELKLADFGLARAFG----IPVRCYSAEVVTLWYRPPDVLFGAKLYS 180 RDLKP+NLL++ N +K+ADFGL+ + C S Y P+V+ G Sbjct: 132 RDLKPENLLLDDNLNVKIADFGLSNIMTDGNFLKTSCGSPN-----YAAPEVINGKLYAG 186 Query: 181 TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYP 240 +D+WS G + + GR F DD+ +P+ Sbjct: 187 PEVDVWSCGIVLYVML-VGRLPF-----DDEF--------------------IPN----- 215 Query: 241 MYPATTSLVNVVPKLNATG-RDLLQNLLKCNPVQRISAEEALQHPYFSDFCP 291 ++ S V V+P + G + L++ ++ +P+QRI+ +E + P+F+ P Sbjct: 216 LFKKVNSCVYVMPDFLSPGAQSLIRRMIVADPMQRITIQEIRRDPWFNVNLP 267 >2WTK-C nrPDB Length = 305 Score = 102 bits (255), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 81/301 (26%), Positives = 146/301 (48%), Gaps = 40/301 (13%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRET--HEIVALKRVRLDDDDEGVPSSALREICLLKEL 58 + KY + +GEG+YG V + + ET V + + + ++ +EI LL+ L Sbjct: 4 IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRL 63 Query: 59 KHKNIVRLHDVLHSD--KKLTLVFEFCDQDLKKYFDSCNGDLDPEI-VKSFLFQLLKGLG 115 +HKN+++L DVL+++ +K+ +V E+C +++ DS P + QL+ GL Sbjct: 64 RHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLIDGLE 123 Query: 116 FCHSRNVLHRDLKPQNLLINRNGELKLADFGLARA---FGIPVRCYSAEVVTLWYRPPDV 172 + HS+ ++H+D+KP NLL+ G LK++ G+A A F C +++ + ++PP++ Sbjct: 124 YLHSQGIVHKDIKPGNLLLTTGGTLKISALGVAEALHPFAADDTCRTSQ-GSPAFQPPEI 182 Query: 173 LFGAKLYST-SIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMT 231 G +S +D+WSAG + P F G D + ++F +G + Sbjct: 183 ANGLDTFSGFKVDIWSAGVTLYNITTGLYP-FEG----DNIYKLFENIGKGS-------Y 230 Query: 232 KLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCP 291 +P + P L+ DLL+ +L+ P +R S + QH +F P Sbjct: 231 AIPG--------------DCGPPLS----DLLKGMLEYEPAKRFSIRQIRQHSWFRKKHP 272 Query: 292 P 292 P Sbjct: 273 P 273 >3Q5I-A nrPDB Length = 504 Score = 102 bits (255), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 88/310 (28%), Positives = 142/310 (45%), Gaps = 57/310 (18%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRV--------RLDDDDEGVP---SSALR 50 + Y K+ K+G G YG V K + H A+K + R DD++ + Sbjct: 36 ESYFKVRKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYSDDNKNIEKFHEEIYN 95 Query: 51 EICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCD------QDLKKY-FDSCNGDLDPEIV 103 EI LLK L H NI++L DV K LV EF + Q + ++ FD C+ I+ Sbjct: 96 EISLLKSLDHPNIIKLFDVFEDKKYFYLVTEFYEGGELFEQIINRHKFDECDA---ANIM 152 Query: 104 KSFLFQLLKGLGFCHSRNVLHRDLKPQNLLI-NRNG--ELKLADFGLARAFGIPVRCYSA 160 K Q+L G+ + H N++HRD+KP+N+L+ N+N +K+ DFGL+ F + Sbjct: 153 K----QILSGICYLHKHNIVHRDIKPENILLENKNSLLNIKIVDFGLSSFFSKDYKL-RD 207 Query: 161 EVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLG 220 + T +Y P+VL K Y+ D+WS G I L G P F G + D +K++ Sbjct: 208 RLGTAYYIAPEVL--KKKYNEKCDVWSCGVIMYILL-CGYPPFGGQNDQDIIKKV----- 259 Query: 221 TPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEA 280 E+ D+K ++ ++L++ +L + +R +AEEA Sbjct: 260 ----EKGKYYFDFNDWKN----------------ISDEAKELIKLMLTYDYNKRCTAEEA 299 Query: 281 LQHPYFSDFC 290 L + + Sbjct: 300 LNSRWIKKYA 309 >6QAU-A nrPDB Length = 280 Score = 102 bits (255), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 71/223 (31%), Positives = 119/223 (53%), Gaps = 24/223 (10%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRE-THEIVALKRVRLDDDDEGVPSSAL---REICLLKEL 58 +Y K + +G G + VF+ ++R+ T VA+K + + + + S + +EI +LKEL Sbjct: 12 EYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSI----NKKNLSKSQILLGKEIKILKEL 67 Query: 59 KHKNIVRLHDVLHSDKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFC 117 +H+NIV L+DV + LV E+C+ DL Y + G L + ++ FL Q+ + Sbjct: 68 QHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQA-KGTLSEDTIRVFLHQIAAAMRIL 126 Query: 118 HSRNVLHRDLKPQNLLI---NRNGE------LKLADFGLARAFGIPVRCYSAEVV-TLWY 167 HS+ ++HRDLKPQN+L+ NR +K+ADFG AR + +A++ + Y Sbjct: 127 HSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARY--LHSNMMAADLCGSPMY 184 Query: 168 RPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDD 210 P+V+ ++ Y D+WS G + + G+P F N D Sbjct: 185 MAPEVIM-SQHYDAKADLWSIGTVIYQCL-VGKPPFQANSPQD 225 >4FG9-A nrPDB Length = 320 Score = 101 bits (252), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 79/289 (27%), Positives = 134/289 (46%), Gaps = 36/289 (12%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 Y+ + +G G + V A+++ T ++VA+K + + EG S EI +L ++KH NI Sbjct: 20 YDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIA-KEALEGKEGSMENEIAVLHKIKHPNI 78 Query: 64 VRLHDVLHSDKKLTLVFEFCDQDLKKYFDSC--NGDLDPEIVKSFLFQLLKGLGFCHSRN 121 V L D+ S L L+ + + FD G +FQ+L + + H Sbjct: 79 VALDDIYESGGHLYLIMQLVSG--GELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLG 136 Query: 122 VLHRDLKPQNLL---INRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL 178 ++HRDLKP+NLL ++ + ++ ++DFGL++ P S T Y P+VL K Sbjct: 137 IVHRDLKPENLLYYSLDEDSKIMISDFGLSK-MEDPGSVLSTACGTPGYVAPEVL-AQKP 194 Query: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKP 238 YS ++D WS G I L P + ND K ++L E P + D Sbjct: 195 YSKAVDCWSIGVIAYILLCGYPPFYDENDA----KLFEQILKAEYEFDSPYWDDISD--- 247 Query: 239 YPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFS 287 + +D +++L++ +P +R + E+ALQHP+ + Sbjct: 248 -------------------SAKDFIRHLMEKDPEKRFTCEQALQHPWIA 277 >6HXF-B nrPDB Length = 302 Score = 101 bits (251), Expect = 4e-22, Method: Compositional matrix adjust. Identities = 83/296 (28%), Positives = 134/296 (45%), Gaps = 42/296 (14%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 +E + ++G+G +G V+KAKN+ET + A K + ++E + EI +L H I Sbjct: 21 WEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEE--LEDYIVEIEILATCDHPYI 78 Query: 64 VRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLD-----PEIVKSFLFQLLKGLGFCH 118 V+L + D KL ++ EFC D+ +LD P+I + Q+L+ L F H Sbjct: 79 VKLLGAYYHDGKLWIMIEFCPGGA---VDAIMLELDRGLTEPQI-QVVCRQMLEALNFLH 134 Query: 119 SRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL 178 S+ ++HRDLK N+L+ G+++LADFG++ ++ + + T ++ P+V+ + Sbjct: 135 SKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETM 194 Query: 179 ----YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLP 234 Y D+WS G E+A + P E P L Sbjct: 195 KDTPYDYKADIWSLGITLIEMAQ---------------------IEPPHHELNPMRVLLK 233 Query: 235 DYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFC 290 K P T S K + RD L+ L NP R SA + L+HP+ S Sbjct: 234 IAKSDPPTLLTPS------KWSVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSIT 283 >4CQG-A nrPDB Length = 331 Score = 100 bits (250), Expect = 5e-22, Method: Compositional matrix adjust. Identities = 88/295 (29%), Positives = 135/295 (45%), Gaps = 36/295 (12%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 ++ YE E IG G + V A + T E+VA+K + + +P EI LK L+H Sbjct: 8 LKYYELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGSDLPRVK-TEIDALKSLRH 66 Query: 61 KNIVRLHDVLHSDKKLTLVFEFC-DQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 ++I +L+ VL + K+ +V E+C +L Y S L E + Q+L + + HS Sbjct: 67 QHICQLYHVLETKNKIFMVLEYCPGGELFDYIIS-QDRLSEEETRVVFRQILSAVAYVHS 125 Query: 120 RNVLHRDLKPQNLLINRNGELKLADFGL-ARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL 178 + HRDLKP+NLL + N +LKL DFGL A+ G +L Y P+++ G Sbjct: 126 QGYAHRDLKPENLLFDENHKLKLIDFGLCAKPKGNKDYHLQECCGSLAYAAPELIQGKSY 185 Query: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKP 238 + D+WS G + L P F ++V K+I R G +W Sbjct: 186 LGSEADVWSMGILLYVLMCGFLP-FDDDNVMALYKKIMR--GKYEVPKW----------- 231 Query: 239 YPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPY-FSDF-CP 291 L+ + LLQ +L+ +P +RIS L HP+ D+ CP Sbjct: 232 ----------------LSPSSILLLQQMLQVDPKKRISMRNLLNHPWVMQDYSCP 270 >2XNP-A nrPDB Length = 279 Score = 100 bits (250), Expect = 6e-22, Method: Compositional matrix adjust. Identities = 78/253 (30%), Positives = 111/253 (43%), Gaps = 19/253 (7%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 + YE L IG G+YG K + + +I+ K + E + E+ LL+ELKH Sbjct: 6 EDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHP 65 Query: 62 NIVRLHDVL--HSDKKLTLVFEFCD-QDLKKYFDSCNGD---LDPEIVKSFLFQLLKGLG 115 NIVR +D + ++ L +V E+C+ DL + LD E V + QL L Sbjct: 66 NIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALK 125 Query: 116 FCHSRN-----VLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPP 170 CH R+ VLHRDLKP N+ ++ +KL DFGLAR V T +Y P Sbjct: 126 ECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSP 185 Query: 171 DVLFGAKLYSTSIDMWSAGCIFAELANAGRPL-------FPGNDVDDQLKRIFRLLGTPT 223 + + Y+ D+WS GC+ EL P G + + +RI Sbjct: 186 EQM-NRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDEL 244 Query: 224 EEQWPSMTKLPDY 236 E M L DY Sbjct: 245 NEIITRMLNLKDY 257 >5IG1-A nrPDB Length = 344 Score = 100 bits (249), Expect = 7e-22, Method: Compositional matrix adjust. Identities = 81/296 (27%), Positives = 129/296 (43%), Gaps = 51/296 (17%) Query: 5 EKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIV 64 +K IG+G + TV + N+ T E+ A+K + L + REI + L+H++IV Sbjct: 20 DKRSVIGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRSSEINKIKREIGICSSLQHEHIV 79 Query: 65 RLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIV----------KSFLFQLLKGL 114 + + LVFE+ G+L EIV + + Q+L L Sbjct: 80 SMRRAFRDESHFYLVFEYVS----------GGELFDEIVTRKFYNEKDASACMHQILSAL 129 Query: 115 GFCHSRNVLHRDLKPQNLLI---NRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPD 171 CHS+N++HRDLKP+NLL+ + N +K+ DFGLA Y T Y P+ Sbjct: 130 QHCHSKNIIHRDLKPENLLLASKDPNAPVKITDFGLA-VIMEQGPTYFGFAGTPGYLSPE 188 Query: 172 VLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMT 231 V+ Y T++D+W+ G I L G P F D +I +W S+T Sbjct: 189 VIRRVP-YDTAVDVWACGVILYILL-VGYPPFWEEDHQKLYAQIKNCQYDFPSPEWDSVT 246 Query: 232 KLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFS 287 ++L++ +L+ NP +R + +E LQHP+ + Sbjct: 247 -------------------------TAAKELIKAMLEPNPKRRPTVQELLQHPWIA 277 >2BRG-A nrPDB Length = 297 Score = 100 bits (249), Expect = 7e-22, Method: Compositional matrix adjust. Identities = 63/199 (31%), Positives = 104/199 (52%), Gaps = 7/199 (3%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 ++ ++ ++ +GEG YG V A NR T E VA+K V + + P + +EIC+ K L H Sbjct: 6 VEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVD-CPENIKKEICINKMLNH 64 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLD-PEI-VKSFLFQLLKGLGFCH 118 +N+V+ + L E+C + FD D+ PE + F QL+ G+ + H Sbjct: 65 ENVVKFYGHRREGNIQYLFLEYCSGG--ELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLH 122 Query: 119 SRNVLHRDLKPQNLLINRNGELKLADFGLARAF--GIPVRCYSAEVVTLWYRPPDVLFGA 176 + HRD+KP+NLL++ LK++DFGLA F R + TL Y P++L Sbjct: 123 GIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRR 182 Query: 177 KLYSTSIDMWSAGCIFAEL 195 + ++ +D+WS G + + Sbjct: 183 EFHAEPVDVWSCGIVLTAM 201 >3TAC-A nrPDB Length = 361 Score = 99.8 bits (247), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 86/297 (28%), Positives = 137/297 (46%), Gaps = 42/297 (14%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDD--DDEGVPSSAL-REICLLKELKH 60 YE E IG+G + V + NRET + A+K V + G+ + L RE + LKH Sbjct: 28 YELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKH 87 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCDQ-----DLKKYFDSCNGDLDPEIVKS-FLFQLLKGL 114 +IV L + SD L +VFEF D ++ K D+ G + E V S ++ Q+L+ L Sbjct: 88 PHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADA--GFVYSEAVASHYMRQILEAL 145 Query: 115 GFCHSRNVLHRDLKPQNLLI---NRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPD 171 +CH N++HRD+KP +L+ + +KL FG+A G V T + P+ Sbjct: 146 RYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFMAPE 205 Query: 172 VLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMT 231 V+ + Y +D+W G I L + P + GT E + + Sbjct: 206 VV-KREPYGKPVDVWGCGVILFILLSGCLPFY----------------GT-KERLFEGII 247 Query: 232 KLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288 K Y M P S ++ + +DL++ +L +P +RI+ EAL HP+ + Sbjct: 248 K----GKYKMNPRQWS------HISESAKDLVRRMLMLDPAERITVYEALNHPWLKE 294 >3HKO-A nrPDB Length = 345 Score = 99.8 bits (247), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 94/339 (27%), Positives = 141/339 (41%), Gaps = 78/339 (23%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALR---EICLLKEL 58 +KY IG+G+YG V A +T I A+K + + + P R E+ L+K+L Sbjct: 26 KKYHLKGAIGQGSYGVVRVAIENQTRAIRAIKIMNKNKIRQINPKDVERIKTEVRLMKKL 85 Query: 59 KHKNIVRLHDVLHSDKKLTLVFEFCD-----QDLKKYFDSCNGDLDPEIVKS-------- 105 H NI RL++V ++ + LV E C L + D G ++VK+ Sbjct: 86 HHPNIARLYEVYEDEQYICLVMELCHGGHLLDKLNVFIDDSTGKCAMDVVKTQICPCPEC 145 Query: 106 ---------------------------FLFQLLKGLGFCHSRNVLHRDLKPQNLLI--NR 136 + Q+ L + H++ + HRD+KP+N L N+ Sbjct: 146 NEEAINGSIHGFRESLDFVQREKLISNIMRQIFSALHYLHNQGICHRDIKPENFLFSTNK 205 Query: 137 NGELKLADFGLARAF----GIPVRCYSAEVVTLWYRPPDVLFGA-KLYSTSIDMWSAGCI 191 + E+KL DFGL++ F + + T ++ P+VL + Y D WSAG + Sbjct: 206 SFEIKLVDFGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEVLNTTNESYGPKCDAWSAGVL 265 Query: 192 FAELANAGRPLFPG-NDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVN 250 L P FPG ND D + + + L P+Y N Sbjct: 266 LHLLLMGAVP-FPGVNDADTISQVLNKKLCFEN----------PNY-------------N 301 Query: 251 VVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDF 289 V+ L RDLL NLL N +R A ALQHP+ S F Sbjct: 302 VLSPL---ARDLLSNLLNRNVDERFDAMRALQHPWISQF 337 >3UDB-A nrPDB Length = 317 Score = 99.8 bits (247), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 78/287 (27%), Positives = 133/287 (46%), Gaps = 32/287 (11%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62 +YE ++ IG G +G ++++ +E+VA+K + + E + + REI + L+H N Sbjct: 20 RYELVKDIGAGNFGVARLMRDKQANELVAVKYI---ERGEKIDENVKREIINHRSLRHPN 76 Query: 63 IVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCN-GDLDPEIVKSFLFQLLKGLGFCHSRN 121 IVR +V+ + L +V E+ + + CN G + + F QL+ G+ + H+ Sbjct: 77 IVRFKEVILTPTHLAIVMEYASGG-ELFERICNAGRFSEDEARFFFQQLISGVSYAHAMQ 135 Query: 122 VLHRDLKPQNLLINRN--GELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLY 179 V HRDLK +N L++ + LK+ADFG ++A + + SA V T Y P+VL + Sbjct: 136 VAHRDLKLENTLLDGSPAPRLKIADFGYSKASVLHSQPKSA-VGTPAYIAPEVLLKKEYD 194 Query: 180 STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPY 239 D+WS G + P + + K I R+L +PDY Sbjct: 195 GKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNV--------QYAIPDY--- 243 Query: 240 PMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286 V++ P+ R L+ + +P +RIS E H +F Sbjct: 244 ---------VHISPEC----RHLISRIFVADPAKRISIPEIRNHEWF 277 >2QNJ-A nrPDB Length = 328 Score = 99.8 bits (247), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 64/221 (28%), Positives = 114/221 (51%), Gaps = 16/221 (7%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSA---LREICLLKELKH 60 Y L+ IG+G + V A++ T VA+K + D + P+S RE+ ++K L H Sbjct: 14 YRLLKTIGKGNFAKVKLARHILTGREVAIKII---DKTQLNPTSLQKLFREVRIMKILNH 70 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 NIV+L +V+ ++K L L+ E+ + +G + + +S Q++ + +CH + Sbjct: 71 PNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQK 130 Query: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVR----CYSAEVVTLWYRPPDVLFGA 176 ++HRDLK +NLL++ + +K+ADFG + F + + C S Y P++ G Sbjct: 131 RIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPP-----YAAPELFQGK 185 Query: 177 KLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFR 217 K +D+WS G I L + P F G ++ + +R+ R Sbjct: 186 KYDGPEVDVWSLGVILYTLVSGSLP-FDGQNLKELRERVLR 225 >3F3Z-A nrPDB Length = 277 Score = 99.8 bits (247), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 90/303 (29%), Positives = 135/303 (44%), Gaps = 61/303 (20%) Query: 1 MQKYEKLEK-IGEGTYGTVFKAKNRETHEIVALKRVR---LDDDDEGVPSSALREICLLK 56 + +Y LE IG G++G V A + T A K++ ++D D +EI ++K Sbjct: 7 INQYYTLENTIGRGSWGEVKIAVQKGTRIRRAAKKIPKYFVEDVDR-----FKQEIEIMK 61 Query: 57 ELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQ------- 109 L H NI+RL++ + + LV E C G+L +V +F+ Sbjct: 62 SLDHPNIIRLYETFEDNTDIYLVMELC----------TGGELFERVVHKRVFRESDAARI 111 Query: 110 ---LLKGLGFCHSRNVLHRDLKPQNLLI---NRNGELKLADFGLARAFGIPVRCYSAEVV 163 +L + +CH NV HRDLKP+N L + + LKL DFGLA F P + +V Sbjct: 112 MKDVLSAVAYCHKLNVAHRDLKPENFLFLTDSPDSPLKLIDFGLAARFK-PGKMMRTKVG 170 Query: 164 TLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPT 223 T +Y P VL G LY D WSAG + L G P F + + +I T Sbjct: 171 TPYYVSPQVLEG--LYGPECDEWSAGVMMYVLL-CGYPPFSAPTDSEVMLKIREGTFTFP 227 Query: 224 EEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQH 283 E+ W +NV P+ L++ LL +P QRI++ +AL+H Sbjct: 228 EKDW---------------------LNVSPQ----AESLIRRLLTKSPKQRITSLQALEH 262 Query: 284 PYF 286 +F Sbjct: 263 EWF 265 >4IAN-A nrPDB Length = 358 Score = 99.8 bits (247), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 93/328 (28%), Positives = 147/328 (44%), Gaps = 48/328 (14%) Query: 2 QKYEKLEKIGEGTYGTVFKAK-NRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 ++Y G+G + V +A+ N ++ VA+K +R ++E + + L+E+ LK+L Sbjct: 30 KRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIR---NNELMQKTGLKELEFLKKLND 86 Query: 61 KN------IVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEI--VKSFLFQLLK 112 + +RL + + L LVFE +L++ D+ I V+S+ QL Sbjct: 87 ADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVGLHIKAVRSYSQQLFL 146 Query: 113 GLGFCHSRNVLHRDLKPQNLLINRNGE-LKLADFGLARAFGIPVRCYSAEVVTLWYRPPD 171 L N+LH D+KP N+L+N + LKL DFG A + + +V+ +YR P+ Sbjct: 147 ALKLLKRCNILHADIKPDNILVNESKTILKLCDFG--SASHVADNDITPYLVSRFYRAPE 204 Query: 172 VLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLG-TPTEEQWPSM 230 ++ G K Y IDMWS GC EL G+ LFPG + LK L G P + + Sbjct: 205 IIIG-KSYDYGIDMWSVGCTLYELY-TGKILFPGKTNNHMLKLAMDLKGKMPNKMIRKGV 262 Query: 231 TKLP--DYKPYPMYPATTSL-----VNVVPKLNATG-----------------------R 260 K D MY + V V+ +N T + Sbjct: 263 FKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLADLIGCQRLPEDQRKKVHQLK 322 Query: 261 DLLQNLLKCNPVQRISAEEALQHPYFSD 288 DLL +L +P +RIS +ALQH + + Sbjct: 323 DLLDQILMLDPAKRISINQALQHAFIQE 350 >6FD3-A nrPDB Length = 300 Score = 99.8 bits (247), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 83/290 (28%), Positives = 131/290 (45%), Gaps = 41/290 (14%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 +KY + EKIG+G GTV+ A + T + VA+K++ L + + EI +++E K+ Sbjct: 22 KKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPK--KELIINEILVMRENKNP 79 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQD--LKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 NIV D +L +V E+ ++C +D + + + L+ L F HS Sbjct: 80 NIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETC---MDEGQIAAVCRECLQALDFLHS 136 Query: 120 RNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLY 179 V+HRD+K N+L+ +G +KL DFG S V T ++ P+V+ K Y Sbjct: 137 NQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVV-TRKAY 195 Query: 180 STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLL---GTPTEEQWPSMTKLPDY 236 +D+WS G + E+ P N + R L+ GTP E Q P Sbjct: 196 GPKVDIWSLGIMAIEMVEGEPPYLNENPL-----RALYLIATNGTP-ELQNPE------- 242 Query: 237 KPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286 +L+A RD L L+ + +R SA+E LQHP+ Sbjct: 243 -----------------RLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFL 275 >4PDS-A nrPDB Length = 347 Score = 99.0 bits (245), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 79/300 (26%), Positives = 137/300 (45%), Gaps = 56/300 (18%) Query: 8 EKIGEGTYGTVFKAKNRETHEIVALKRV---RLDDDDEGVPSSALREICLLKELKHKNIV 64 E +G+G + TV KA R T + ++K + ++ + +GV RE+ +L++L H IV Sbjct: 37 EVVGQGAFATVKKAIERTTGKTFSVKIISKRKVIGNMDGVT----RELEVLQKLNHPRIV 92 Query: 65 RLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLH 124 RL + +V EF F + +G + + + Q+L + + HS + H Sbjct: 93 RLKGFYEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSMGISH 152 Query: 125 RDLKPQNLLINRNGE--LKLADFGLARAFG----IPVRCYSAEVVTLWYRPPDVLFGAKL 178 RDLKP N+LI ++ +K+ FGLA+ G + C TL Y P+V+ G Sbjct: 153 RDLKPDNILIEQDDPVLVKITAFGLAKVQGNGSFMKTFCG-----TLAYVAPEVIRGKDT 207 Query: 179 ------------YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQ 226 YS+ +DMWS GC+ + P F G+ D ++++ +G + + Sbjct: 208 SVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLP-FSGSTQD----QLYKQIGRGSYHE 262 Query: 227 WPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286 P L D+ +++ RD + +LL+ +P R +A +AL HP+ Sbjct: 263 GP----LKDF-----------------RISEEARDFIDSLLQVDPNNRSTAAKALNHPWI 301 >4B6L-A nrPDB Length = 281 Score = 99.0 bits (245), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 85/297 (28%), Positives = 132/297 (44%), Gaps = 42/297 (14%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALK-----RVRLDDDDEGVPSSALREICLLK 56 + Y K +G+G + ++A + ET A+K RV E + L EI L + Sbjct: 9 RTYLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKI----LNEIELHR 64 Query: 57 ELKHKNIVRLHDVLHSDKKLTLVFEFCD-QDLKKYFDSCNGDLDPEIVKSFLFQLLKGLG 115 +L+H++IVR + + E C + L + + + L+PE V+ +L Q+L GL Sbjct: 65 DLQHRHIVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPE-VRYYLRQILSGLK 123 Query: 116 FCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFG 175 + H R +LHRDLK N I N ELK+ DFGLA P + T Y P+VL Sbjct: 124 YLHQRGILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLL- 182 Query: 176 AKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPD 235 + + D+WS GC+ L G P F D+ + + I ++ T Sbjct: 183 RQGHGPEADVWSLGCVMYTLL-CGSPPFETADLKETYRCIKQVHYT-------------- 227 Query: 236 YKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 292 PA+ SL R LL +L+ +P R S ++ L+H +F+ P Sbjct: 228 ------LPASLSL---------PARQLLAAILRASPRDRPSIDQILRHDFFTKGYTP 269 >5KZ7-A nrPDB Length = 346 Score = 98.2 bits (243), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 60/218 (27%), Positives = 111/218 (50%), Gaps = 10/218 (4%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 Y L+ IG+G + V A++ T + VA+K + + RE+ ++K L H NI Sbjct: 35 YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNI 94 Query: 64 VRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVL 123 V+L +V+ ++K L LV E+ + +G + + ++ Q++ + +CH + ++ Sbjct: 95 VKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIV 154 Query: 124 HRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLW----YRPPDVLFGAKLY 179 HRDLK +NLL++ + +K+ADFG + F + ++ T Y P++ G K Sbjct: 155 HRDLKAENLLLDADMNIKIADFGFSNEF-----TFGNKLDTFCGSPPYAAPELFQGKKYD 209 Query: 180 STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFR 217 +D+WS G I L + P F G ++ + +R+ R Sbjct: 210 GPEVDVWSLGVILYTLVSGSLP-FDGQNLKELRERVLR 246 >2Q0N-A nrPDB Length = 301 Score = 97.8 bits (242), Expect = 5e-21, Method: Compositional matrix adjust. Identities = 72/284 (25%), Positives = 128/284 (45%), Gaps = 31/284 (10%) Query: 9 KIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHD 68 KIGEG+ G V A R + ++VA+K++ L E+ ++++ +H+N+V +++ Sbjct: 36 KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRR--ELLFNEVVIMRDYQHENVVEMYN 93 Query: 69 VLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLK 128 +L +V EF + + ++ E + + +L+ L H++ V+HRD+K Sbjct: 94 SYLVGDELWVVMEFLEGGALTDI-VTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIK 152 Query: 129 PQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSA 188 ++L+ +G +KL+DFG V + V T ++ P+ L Y +D+WS Sbjct: 153 SDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE-LISRLPYGPEVDIWSL 211 Query: 189 GCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSL 248 G + E+ + P F E +M + D P P +L Sbjct: 212 GIMVIEMVDGEPPYF-------------------NEPPLKAMKMIRDNLP----PRLKNL 248 Query: 249 VNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 292 V P L + L LL +P QR +A E L+HP+ + PP Sbjct: 249 HKVSPSL----KGFLDRLLVRDPAQRATAAELLKHPFLAKAGPP 288 >4JDH-A nrPDB Length = 346 Score = 97.8 bits (242), Expect = 5e-21, Method: Compositional matrix adjust. Identities = 72/284 (25%), Positives = 128/284 (45%), Gaps = 31/284 (10%) Query: 9 KIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHD 68 KIGEG+ G V A R + ++VA+K++ L E+ ++++ +H+N+V +++ Sbjct: 81 KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRR--ELLFNEVVIMRDYQHENVVEMYN 138 Query: 69 VLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLK 128 +L +V EF + + ++ E + + +L+ L H++ V+HRD+K Sbjct: 139 SYLVGDELWVVMEFLEGGALTDI-VTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIK 197 Query: 129 PQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSA 188 ++L+ +G +KL+DFG V + V T ++ P+ L Y +D+WS Sbjct: 198 SDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE-LISRLPYGPEVDIWSL 256 Query: 189 GCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSL 248 G + E+ + P F E +M + D P P +L Sbjct: 257 GIMVIEMVDGEPPYF-------------------NEPPLKAMKMIRDNLP----PRLKNL 293 Query: 249 VNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 292 V P L + L LL +P QR +A E L+HP+ + PP Sbjct: 294 HKVSPSL----KGFLDRLLVRDPAQRATAAELLKHPFLAKAGPP 333 >4RED-A nrPDB Length = 351 Score = 97.4 bits (241), Expect = 6e-21, Method: Compositional matrix adjust. Identities = 79/294 (26%), Positives = 133/294 (45%), Gaps = 50/294 (17%) Query: 8 EKIGEGTYGTVFKAKNRETHEIVALK---RVRLDDDDEGVPSSALREICLLKELKHKNIV 64 + +G GT+G V K+ T VA+K R ++ D V REI LK +H +I+ Sbjct: 20 DTLGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLD--VVGKIRREIQNLKLFRHPHII 77 Query: 65 RLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLH 124 +L+ V+ + + +V E+ + NG LD + + Q+L G+ +CH V+H Sbjct: 78 KLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVH 137 Query: 125 RDLKPQNLLINRNGELKLADFGLARAFG----IPVRCYSAEVVTLWYRPPDVLFGAKLYS 180 RDLKP+N+L++ + K+ADFGL+ + C S Y P+V+ G Sbjct: 138 RDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPN-----YAAPEVISGRLYAG 192 Query: 181 TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPD---YK 237 +D+WS+G I L P DD + +F+ K+ D Y Sbjct: 193 PEVDIWSSGVILYALLCGTLPF-----DDDHVPTLFK--------------KICDGIFYT 233 Query: 238 PYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCP 291 P + P+ S LL+++L+ +P++R S ++ +H +F P Sbjct: 234 PQYLNPSVIS--------------LLKHMLQVDPMKRASIKDIREHEWFKQDLP 273 >4KS7-A nrPDB Length = 292 Score = 97.4 bits (241), Expect = 6e-21, Method: Compositional matrix adjust. Identities = 72/278 (25%), Positives = 129/278 (46%), Gaps = 31/278 (11%) Query: 9 KIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHD 68 KIGEG+ G V A+ + + VA+K + L E+ ++++ +H N+V ++ Sbjct: 30 KIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRR--ELLFNEVVIMRDYQHFNVVEMYK 87 Query: 69 VLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLK 128 ++L ++ EF S L+ E + + +L+ L + H++ V+HRD+K Sbjct: 88 SYLVGEELWVLMEFLQGGALTDIVS-QVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIK 146 Query: 129 PQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSA 188 ++L+ +G +KL+DFG V + V T ++ P+V+ LY+T +D+WS Sbjct: 147 SDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVI-SRSLYATEVDIWSL 205 Query: 189 GCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSL 248 G + E+ + P F + V +M +L D P P + Sbjct: 206 GIMVIEMVDGEPPYFSDSPVQ-------------------AMKRLRDSPP----PKLKNS 242 Query: 249 VNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286 V P L RD L+ +L +P +R +A+E L HP+ Sbjct: 243 HKVSPVL----RDFLERMLVRDPQERATAQELLDHPFL 276 >3UTO-A nrPDB Length = 573 Score = 97.4 bits (241), Expect = 6e-21, Method: Compositional matrix adjust. Identities = 78/291 (26%), Positives = 130/291 (44%), Gaps = 35/291 (12%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 + Y+ E++G G +G V + R T A K V + + + +EI + L+H Sbjct: 156 LDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESD--KETVRKEIQTMSVLRH 213 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCDQD--LKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCH 118 +V LHD D ++ +++EF +K D N + E V+ ++ Q+ KGL H Sbjct: 214 PTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVE-YMRQVCKGLCHMH 272 Query: 119 SRNVLHRDLKPQNLLIN--RNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGA 176 N +H DLKP+N++ R+ ELKL DFGL A P + T + P+V G Sbjct: 273 ENNYVHLDLKPENIMFTTKRSNELKLIDFGLT-AHLDPKQSVKVTTGTAEFAAPEVAEG- 330 Query: 177 KLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDY 236 K DMWS G + L + P F G + D+ L+ + W + D Sbjct: 331 KPVGYYTDMWSVGVLSYILLSGLSP-FGGENDDETLRNVKSC-------DW----NMDD- 377 Query: 237 KPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFS 287 + ++ G+D ++ LL +P R++ +AL+HP+ + Sbjct: 378 -------------SAFSGISEDGKDFIRKLLLADPNTRMTIHQALEHPWLT 415 >4XBR-A nrPDB Length = 366 Score = 97.1 bits (240), Expect = 7e-21, Method: Compositional matrix adjust. Identities = 72/284 (25%), Positives = 128/284 (45%), Gaps = 31/284 (10%) Query: 9 KIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHD 68 KIGEG+ G V A R + ++VA+K++ L E+ ++++ +H+N+V +++ Sbjct: 101 KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRR--ELLFNEVVIMRDYQHENVVEMYN 158 Query: 69 VLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLK 128 +L +V EF + + ++ E + + +L+ L H++ V+HRD+K Sbjct: 159 SYLVGDELWVVMEFLEGGALTDI-VTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIK 217 Query: 129 PQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSA 188 ++L+ +G +KL+DFG V + V T ++ P+ L Y +D+WS Sbjct: 218 SDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE-LISRLPYGPEVDIWSL 276 Query: 189 GCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSL 248 G + E+ + P F E +M + D P P +L Sbjct: 277 GIMVIEMVDGEPPYF-------------------NEPPLKAMKMIRDNLP----PRLKNL 313 Query: 249 VNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 292 V P L + L LL +P QR +A E L+HP+ + PP Sbjct: 314 HKVSPSL----KGFLDRLLVRDPAQRATAAELLKHPFLAKAGPP 353 >1KOA-A nrPDB Length = 491 Score = 97.1 bits (240), Expect = 7e-21, Method: Compositional matrix adjust. Identities = 78/291 (26%), Positives = 131/291 (45%), Gaps = 35/291 (12%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 + Y+ E++G G +G V + R T A K V + + + +EI + L+H Sbjct: 50 LDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESD--KETVRKEIQTMSVLRH 107 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCD--QDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCH 118 +V LHD D ++ +++EF + +K D N + E V+ ++ Q+ KGL H Sbjct: 108 PTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVE-YMRQVCKGLCHMH 166 Query: 119 SRNVLHRDLKPQNLLIN--RNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGA 176 N +H DLKP+N++ R+ ELKL DFGL A P + T + P+V G Sbjct: 167 ENNYVHLDLKPENIMFTTKRSNELKLIDFGLT-AHLDPKQSVKVTTGTAEFAAPEVAEG- 224 Query: 177 KLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDY 236 K DMWS G + L + P F G + D+ L+ + W + D Sbjct: 225 KPVGYYTDMWSVGVLSYILLSGLSP-FGGENDDETLRNVKSC-------DW----NMDD- 271 Query: 237 KPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFS 287 + ++ G+D ++ LL +P R++ +AL+HP+ + Sbjct: 272 -------------SAFSGISEDGKDFIRKLLLADPNTRMTIHQALEHPWLT 309 >4FIE-A nrPDB Length = 423 Score = 97.1 bits (240), Expect = 9e-21, Method: Compositional matrix adjust. Identities = 72/284 (25%), Positives = 128/284 (45%), Gaps = 31/284 (10%) Query: 9 KIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHD 68 KIGEG+ G V A R + ++VA+K++ L E+ ++++ +H+N+V +++ Sbjct: 158 KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRR--ELLFNEVVIMRDYQHENVVEMYN 215 Query: 69 VLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLK 128 +L +V EF + + ++ E + + +L+ L H++ V+HRD+K Sbjct: 216 SYLVGDELWVVMEFLEGGALTDI-VTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIK 274 Query: 129 PQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSA 188 ++L+ +G +KL+DFG V + V T ++ P+ L Y +D+WS Sbjct: 275 SDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE-LISRLPYGPEVDIWSL 333 Query: 189 GCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSL 248 G + E+ + P F E +M + D P P +L Sbjct: 334 GIMVIEMVDGEPPYF-------------------NEPPLKAMKMIRDNLP----PRLKNL 370 Query: 249 VNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 292 V P L + L LL +P QR +A E L+HP+ + PP Sbjct: 371 HKVSPSL----KGFLDRLLVRDPAQRATAAELLKHPFLAKAGPP 410 >6GVJ-A nrPDB Length = 429 Score = 97.1 bits (240), Expect = 9e-21, Method: Compositional matrix adjust. Identities = 82/296 (27%), Positives = 132/296 (44%), Gaps = 44/296 (14%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN- 62 Y L++IG G VF+ N E +I A+K V L++ D S EI L +L+ + Sbjct: 146 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 204 Query: 63 -IVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN 121 I+RL+D +D+ + +V E + DL + +DP KS+ +L+ + H Sbjct: 205 KIIRLYDYEITDQYIYMVMECGNIDLNSWLKK-KKSIDPWERKSYWKNMLEAVHTIHQHG 263 Query: 122 VLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCY--SAEVVTLWYRPPDVL------ 173 ++H DLKP N LI +G LKL DFG+A ++V T+ Y PP+ + Sbjct: 264 IVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSS 322 Query: 174 ----FGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPS 229 S D+WS GCI + P + +Q+ ++ ++ E ++P Sbjct: 323 RENGKSKSKISPKSDVWSLGCILYYMTYGKTPF---QQIINQISKLHAIIDPNHEIEFPD 379 Query: 230 MTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPY 285 +P+ + +D+L+ LK +P QRIS E L HPY Sbjct: 380 ----------------------IPEKDL--QDVLKCCLKRDPKQRISIPELLAHPY 411 >4REW-A nrPDB Length = 540 Score = 97.1 bits (240), Expect = 9e-21, Method: Compositional matrix adjust. Identities = 79/294 (26%), Positives = 133/294 (45%), Gaps = 50/294 (17%) Query: 8 EKIGEGTYGTVFKAKNRETHEIVALK---RVRLDDDDEGVPSSALREICLLKELKHKNIV 64 + +G GT+G V K+ T VA+K R ++ D V REI LK +H +I+ Sbjct: 12 DTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLD--VVGKIRREIQNLKLFRHPHII 69 Query: 65 RLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLH 124 +L+ V+ + + +V E+ + NG LD + + Q+L G+ +CH V+H Sbjct: 70 KLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVH 129 Query: 125 RDLKPQNLLINRNGELKLADFGLARAFG----IPVRCYSAEVVTLWYRPPDVLFGAKLYS 180 RDLKP+N+L++ + K+ADFGL+ + C S Y P+V+ G Sbjct: 130 RDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPN-----YAAPEVISGRLYAG 184 Query: 181 TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPD---YK 237 +D+WS+G I L P DD + +F+ K+ D Y Sbjct: 185 PEVDIWSSGVILYALLCGTLPF-----DDDHVPTLFK--------------KICDGIFYT 225 Query: 238 PYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCP 291 P + P+ S LL+++L+ +P++R S ++ +H +F P Sbjct: 226 PQYLNPSVIS--------------LLKHMLQVDPMKRASIKDIREHEWFKQDLP 265 >3ZUT-A nrPDB Length = 362 Score = 96.3 bits (238), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 75/287 (26%), Positives = 132/287 (45%), Gaps = 32/287 (11%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62 +YE ++ IG G +G ++++++E+VA+K + + E + + REI + L+H N Sbjct: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKYI---ERGEKIDENVKREIINHRSLRHPN 76 Query: 63 IVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCN-GDLDPEIVKSFLFQLLKGLGFCHSRN 121 IVR +V+ + L +V E+ + + CN G + + F QL+ G+ +CH+ Sbjct: 77 IVRFKEVILTPTHLAIVMEYASGG-ELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQ 135 Query: 122 VLHRDLKPQNLLINRN--GELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLY 179 V HRDLK +N L++ + LK+ FG +++ + + S V T Y P+VL + Sbjct: 136 VCHRDLKLENTLLDGSPAPRLKICAFGYSKSSVLHSQPKST-VGTPAYIAPEVLLKKEYD 194 Query: 180 STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPY 239 D+WS G + P + + K I R+L +PDY Sbjct: 195 GKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNV--------QYAIPDY--- 243 Query: 240 PMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286 V++ P+ R L+ + +P +RIS E H +F Sbjct: 244 ---------VHISPEC----RHLISRIFVADPAKRISIPEIRNHEWF 277 >2HAK-A nrPDB Length = 328 Score = 95.9 bits (237), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 63/221 (28%), Positives = 113/221 (51%), Gaps = 16/221 (7%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSA---LREICLLKELKH 60 Y + IG+G + V A++ T VA+K + D + P+S RE+ ++K L H Sbjct: 17 YRLQKTIGKGNFAKVKLARHVLTGREVAVKII---DKTQLNPTSLQKLFREVRIMKILNH 73 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 NIV+L +V+ ++K L LV E+ + +G + + ++ Q++ + +CH + Sbjct: 74 PNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQK 133 Query: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVR----CYSAEVVTLWYRPPDVLFGA 176 ++HRDLK +NLL++ + +K+ADFG + F + + C S Y P++ G Sbjct: 134 YIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPP-----YAAPELFQGK 188 Query: 177 KLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFR 217 K +D+WS G I L + P F G ++ + +R+ R Sbjct: 189 KYDGPEVDVWSLGVILYTLVSGSLP-FDGQNLKELRERVLR 228 >4CFH-A nrPDB Length = 493 Score = 95.9 bits (237), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 78/294 (26%), Positives = 133/294 (45%), Gaps = 50/294 (17%) Query: 8 EKIGEGTYGTVFKAKNRETHEIVALK---RVRLDDDDEGVPSSALREICLLKELKHKNIV 64 + +G GT+G V K+ T VA+K R ++ D V REI LK +H +I+ Sbjct: 39 DTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLD--VVGKIRREIQNLKLFRHPHII 96 Query: 65 RLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLH 124 +L+ V+ + + +V E+ + NG LD + + Q+L G+ +CH V+H Sbjct: 97 KLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVH 156 Query: 125 RDLKPQNLLINRNGELKLADFGLARAFG----IPVRCYSAEVVTLWYRPPDVLFGAKLYS 180 RDLKP+N+L++ + K+ADFGL+ + C S Y P+V+ G Sbjct: 157 RDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPN-----YAAPEVISGRLYAG 211 Query: 181 TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPD---YK 237 +D+WS+G I L P DD + +F+ K+ D Y Sbjct: 212 PEVDIWSSGVILYALLCGTLPF-----DDDHVPTLFK--------------KICDGIFYT 252 Query: 238 PYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCP 291 P + P+ S LL+++L+ +P++R + ++ +H +F P Sbjct: 253 PQYLNPSVIS--------------LLKHMLQVDPMKRATIKDIREHEWFKQDLP 292 >3HMP-A nrPDB Length = 342 Score = 95.9 bits (237), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 84/299 (28%), Positives = 135/299 (45%), Gaps = 50/299 (16%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN- 62 Y L++IG G VF+ N E +I A+K V L++ D S EI L +L+ + Sbjct: 58 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 116 Query: 63 -IVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN 121 I+RL+D +D+ + +V E + DL + +DP KS+ +L+ + H Sbjct: 117 KIIRLYDYEITDQYIYMVMECGNIDLNSWLKK-KKSIDPWERKSYWKNMLEAVHTIHQHG 175 Query: 122 VLHRDLKPQNLLINRNGELKLADFGLARAF--GIPVRCYSAEVVTLWYRPPDVLFGAKLY 179 ++H DLKP N LI +G LKL DFG+A ++V T+ Y PP+ + K Sbjct: 176 IVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAI---KDM 231 Query: 180 STS-------------IDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQ 226 S+S D+WS GCI + P + +Q+ ++ ++ E + Sbjct: 232 SSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF---QQIINQISKLHAIIDPNHEIE 288 Query: 227 WPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPY 285 +P +P+ + +D+L+ LK +P QRIS E L HPY Sbjct: 289 FPD----------------------IPEKDL--QDVLKCCLKRDPKQRISIPELLAHPY 323 >3Q53-A nrPDB Length = 306 Score = 95.9 bits (237), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 81/290 (27%), Positives = 130/290 (44%), Gaps = 41/290 (14%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 +KY + EKIG+G GTV+ A + T + VA++++ L + + EI +++E K+ Sbjct: 21 KKYTRFEKIGQGASGTVYTAMDVATGQEVAIRQMNLQQQPK--KELIINEILVMRENKNP 78 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQD--LKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 NIV D +L +V E+ ++C +D + + + L+ L F HS Sbjct: 79 NIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETC---MDEGQIAAVCRECLQALEFLHS 135 Query: 120 RNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLY 179 V+HRD+K N+L+ +G +KL DFG S V T ++ P+V+ K Y Sbjct: 136 NQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVV-TRKAY 194 Query: 180 STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLL---GTPTEEQWPSMTKLPDY 236 +D+WS G + E+ P N + R L+ GTP E Q P Sbjct: 195 GPKVDIWSLGIMAIEMIEGEPPYLNENPL-----RALYLIATNGTP-ELQNPE------- 241 Query: 237 KPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286 KL+A RD L L+ + +R SA+E +QH + Sbjct: 242 -----------------KLSAIFRDFLNRCLEMDVEKRGSAKELIQHQFL 274 >2VN9-A nrPDB Length = 301 Score = 95.5 bits (236), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 80/294 (27%), Positives = 132/294 (44%), Gaps = 44/294 (14%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62 +Y+ E++G+G + V + T + A K + RE + + LKH N Sbjct: 5 EYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPN 64 Query: 63 IVRLHDVLHSDKKLTLVFE-------FCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLG 115 IVRLHD + + LVF+ F D ++Y+ + + Q+L+ + Sbjct: 65 IVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADAS-------HCIQQILESVN 117 Query: 116 FCHSRNVLHRDLKPQNLLI---NRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDV 172 CH ++HRDLKP+NLL+ ++ +KLADFGLA + + T Y P+V Sbjct: 118 HCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEV 177 Query: 173 LFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTK 232 L Y +DMW+ G I L P + D+ R+++ + + +PS Sbjct: 178 L-RKDPYGKPVDMWACGVILYILLVGYPPFW-----DEDQHRLYQQIKAGAYD-FPS--- 227 Query: 233 LPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286 P++ V P+ +DL+ +L NP +RI+A EAL+HP+ Sbjct: 228 -PEWD------------TVTPE----AKDLINKMLTINPAKRITASEALKHPWI 264 >6C9D-A nrPDB Length = 459 Score = 95.5 bits (236), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 63/221 (28%), Positives = 113/221 (51%), Gaps = 16/221 (7%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSA---LREICLLKELKH 60 Y + IG+G + V A++ T VA+K + D + P+S RE+ ++K L H Sbjct: 23 YRLQKTIGKGNFAKVKLARHVLTGREVAVKII---DKTQLNPTSLQKLFREVRIMKILNH 79 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 NIV+L +V+ ++K L LV E+ + +G + + ++ Q++ + +CH + Sbjct: 80 PNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQK 139 Query: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVR----CYSAEVVTLWYRPPDVLFGA 176 ++HRDLK +NLL++ + +K+ADFG + F + + C S Y P++ G Sbjct: 140 YIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDEFCGSPP-----YAAPELFQGK 194 Query: 177 KLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFR 217 K +D+WS G I L + P F G ++ + +R+ R Sbjct: 195 KYDGPEVDVWSLGVILYTLVSGSLP-FDGQNLKELRERVLR 234 >5AP3-A nrPDB Length = 313 Score = 95.5 bits (236), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 84/299 (28%), Positives = 135/299 (45%), Gaps = 50/299 (16%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN- 62 Y L++IG G VF+ N E +I A+K V L++ D S EI L +L+ + Sbjct: 30 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 88 Query: 63 -IVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN 121 I+RL+D +D+ + +V E + DL + +DP KS+ +L+ + H Sbjct: 89 KIIRLYDYEITDQYIYMVMECGNIDLNGWLKK-KKSIDPWERKSYWKNMLEAVHTIHQHG 147 Query: 122 VLHRDLKPQNLLINRNGELKLADFGLARAF--GIPVRCYSAEVVTLWYRPPDVLFGAKLY 179 ++H DLKP N LI +G LKL DFG+A ++V T+ Y PP+ + K Sbjct: 148 IVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAI---KDM 203 Query: 180 STS-------------IDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQ 226 S+S D+WS GCI + P + +Q+ ++ ++ E + Sbjct: 204 SSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF---QQIINQISKLHAIIDPNHEIE 260 Query: 227 WPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPY 285 +P +P+ + +D+L+ LK +P QRIS E L HPY Sbjct: 261 FPD----------------------IPEKDL--QDVLKCCLKRDPKQRISIPELLAHPY 295 >4QMW-A nrPDB Length = 310 Score = 95.5 bits (236), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 62/199 (31%), Positives = 105/199 (52%), Gaps = 5/199 (2%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 + KLEKIG+G++G VFK + T ++VA+K + L++ ++ + +EI +L + + Sbjct: 31 FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQ-QEITVLSQCDSPYV 89 Query: 64 VRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCN-GDLDPEIVKSFLFQLLKGLGFCHSRNV 122 + + D KL ++ E+ D G LD + + L ++LKGL + HS Sbjct: 90 TKYYGSYLKDTKLWIIMEYLGGG--SALDLLEPGPLDETQIATILREILKGLDYLHSEKK 147 Query: 123 LHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTS 182 +HRD+K N+L++ +GE+KLADFG+A + V T ++ P+V+ Y + Sbjct: 148 IHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI-KQSAYDSK 206 Query: 183 IDMWSAGCIFAELANAGRP 201 D+WS G ELA P Sbjct: 207 ADIWSLGITAIELARGEPP 225 >4WNO-A nrPDB Length = 287 Score = 95.5 bits (236), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 65/213 (30%), Positives = 107/213 (50%), Gaps = 19/213 (8%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEI-VALKRVRLDDDDEGVPSSAL--REICLLKELK 59 ++ + + IG G + VFK ++R H++ VA+K + + S L +EI +LKELK Sbjct: 19 EFSRKDLIGHGAFAVVFKGRHRAAHDLEVAVKCI---NKKNLAKSQTLLGKEIKILKELK 75 Query: 60 HKNIVRLHDVLHSDKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCH 118 H+NIV L+D + LV E+C+ DL Y + L + ++ FL Q+ + H Sbjct: 76 HENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMR-TLSEDTIRLFLQQIAGAMRLLH 134 Query: 119 SRNVLHRDLKPQNLLINRNG---------ELKLADFGLARAFGIPVRCYSAEVVTLWYRP 169 S+ ++HRDLKPQN+L++ +K+ADFG AR + + + Y Sbjct: 135 SKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMA-ATLCGSPMYMA 193 Query: 170 PDVLFGAKLYSTSIDMWSAGCIFAELANAGRPL 202 P+V+ ++ Y D+WS G I + P Sbjct: 194 PEVIM-SQHYDGKADLWSIGTIVYQCLTGKAPF 225 >2F57-A nrPDB Length = 317 Score = 94.7 bits (234), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 72/285 (25%), Positives = 130/285 (45%), Gaps = 33/285 (11%) Query: 9 KIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHD 68 KIGEG+ G V A + T + VA+K++ L E+ ++++ H N+V ++ Sbjct: 52 KIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRR--ELLFNEVVIMRDYHHDNVVDMYS 109 Query: 69 VLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLK 128 +L +V EF + + + ++ E + + +L+ L + H++ V+HRD+K Sbjct: 110 SYLVGDELWVVMEFLEGGALTDIVT-HTRMNEEQIATVCLSVLRALSYLHNQGVIHRDIK 168 Query: 129 PQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL-YSTSIDMWS 187 ++L+ +G +KL+DFG V + V T ++ P+V+ ++L Y T +D+WS Sbjct: 169 SDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVI--SRLPYGTEVDIWS 226 Query: 188 AGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTS 247 G + E+ + P F E +M ++ D P P Sbjct: 227 LGIMVIEMIDGEPPYF-------------------NEPPLQAMRRIRDSLP----PRVKD 263 Query: 248 LVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 292 L K+++ R L +L P QR +A+E L HP+ PP Sbjct: 264 L----HKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPP 304 >4KIK-B nrPDB Length = 677 Score = 94.7 bits (234), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 68/217 (31%), Positives = 108/217 (49%), Gaps = 23/217 (10%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALR---EICLLKELKH 60 +E E++G G +G V + N+ET E +A+K+ R E P + R EI +++ L H Sbjct: 21 WEMKERLGTGGFGNVIRWHNQETGEQIAIKQCR----QELSPRNRERWCLEIQIMRRLTH 76 Query: 61 KNIVRLHDVLHSDKKLT------LVFEFCDQ-DLKKY---FDSCNGDLDPEIVKSFLFQL 110 N+V DV + L L E+C DL+KY F++C G + I+ + L + Sbjct: 77 PNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAIL-TLLSDI 135 Query: 111 LKGLGFCHSRNVLHRDLKPQNLLINRNGEL---KLADFGLARAFGIPVRCYSAEVVTLWY 167 L + H ++HRDLKP+N+++ + + K+ D G A+ C S V TL Y Sbjct: 136 ASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSF-VGTLQY 194 Query: 168 RPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFP 204 P++L K Y+ ++D WS G + E RP P Sbjct: 195 LAPELLEQQK-YTVTVDYWSFGTLAFECITGFRPFLP 230 >5D7A-A nrPDB Length = 308 Score = 94.4 bits (233), Expect = 5e-20, Method: Compositional matrix adjust. Identities = 65/214 (30%), Positives = 106/214 (49%), Gaps = 20/214 (9%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH-KN 62 +E +E +G GTYG V+K ++ +T ++ A+K + + D+E +EI +LK+ H +N Sbjct: 19 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEE---EEIKQEINMLKKYSHHRN 75 Query: 63 IVRLHDVL------HSDKKLTLVFEFCD----QDLKKYFDSCNGDLDPEIVKSFLFQLLK 112 I + D +L LV EFC DL K ++ L E + ++L+ Sbjct: 76 IATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIK--NTKGNTLKEEWIAYICREILR 133 Query: 113 GLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDV 172 GL H V+HRD+K QN+L+ N E+KL DFG++ V + + T ++ P+V Sbjct: 134 GLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEV 193 Query: 173 LFGAK----LYSTSIDMWSAGCIFAELANAGRPL 202 + + Y D+WS G E+A PL Sbjct: 194 IACDENPDATYDFKSDLWSLGITAIEMAEGAPPL 227 >4D2V-A nrPDB Length = 356 Score = 93.6 bits (231), Expect = 8e-20, Method: Compositional matrix adjust. Identities = 82/288 (28%), Positives = 129/288 (44%), Gaps = 34/288 (11%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 ++ YE E IG G + V A + T E+VA+K + + +P EI LK L+H Sbjct: 28 LKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIK-TEIEALKNLRH 86 Query: 61 KNIVRLHDVLHSDKKLTLVFEFC-DQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 ++I +L+ VL + K+ +V E+C +L Y S L E + Q++ + + HS Sbjct: 87 QHICQLYHVLETANKIFMVLEYCPGGELFDYIIS-QDRLSEEETRVVFRQIVSAVAYVHS 145 Query: 120 RNVLHRDLKPQNLLINRNGELKLADFGL-ARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL 178 + HRDLKP+NLL + +LKL DFGL A+ G A L Y P+++ G Sbjct: 146 QGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQACCGALAYAAPELIQGKSY 205 Query: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKP 238 + D+WS G + L P F + + +I R G +W S + + Sbjct: 206 LGSEADVWSMGILLYVLMCGFLP-FDDDTAAALVAKIMR--GKYDVPKWLSPSSIL---- 258 Query: 239 YPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286 LLQ +L+ +P +RIS + L HP+ Sbjct: 259 -----------------------LLQQMLQVDPKKRISMKNLLNHPWI 283 >2ZMD-A nrPDB Length = 390 Score = 93.6 bits (231), Expect = 9e-20, Method: Compositional matrix adjust. Identities = 83/299 (27%), Positives = 134/299 (44%), Gaps = 50/299 (16%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN- 62 Y L++IG G VF+ N E +I A+K V L++ D S EI L +L+ + Sbjct: 58 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 116 Query: 63 -IVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN 121 I+RL+D +D+ + +V E + DL + +DP KS+ +L+ + H Sbjct: 117 KIIRLYDYEITDQYIYMVMECGNIDLNSWLKK-KKSIDPWERKSYWKNMLEAVHTIHQHG 175 Query: 122 VLHRDLKPQNLLINRNGELKLADFGLARAF--GIPVRCYSAEVVTLWYRPPDVLFGAKLY 179 ++H DLKP N LI +G LKL DFG+A ++V + Y PP+ + K Sbjct: 176 IVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGAVNYMPPEAI---KDM 231 Query: 180 STS-------------IDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQ 226 S+S D+WS GCI + P + +Q+ ++ ++ E + Sbjct: 232 SSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF---QQIINQISKLHAIIDPNHEIE 288 Query: 227 WPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPY 285 +P +P+ + +D+L+ LK +P QRIS E L HPY Sbjct: 289 FPD----------------------IPEKDL--QDVLKCCLKRDPKQRISIPELLAHPY 323 >4CSV-A nrPDB Length = 275 Score = 93.6 bits (231), Expect = 9e-20, Method: Compositional matrix adjust. Identities = 63/220 (28%), Positives = 113/220 (51%), Gaps = 18/220 (8%) Query: 9 KIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSA--LREICLLKELKHKNIVRL 66 K+G G +G V++ K R + VA+K ++ EG S L+E ++K+LKH N+V+L Sbjct: 18 KLGSGQFGEVYEGKWRNYNIEVAVKTLK-----EGTMSVEEFLQEAQIMKKLKHPNLVQL 72 Query: 67 HDVLHSDKKLTLVFEFCDQ-DLKKYFDSCNG-DLDPEIVKSFLFQLLKGLGFCHSRNVLH 124 + V + + ++ E+ L Y C G ++ + + Q+ G+ + S+N +H Sbjct: 73 YGVCTKEPPIYIITEYMSHGSLLDYLRDCEGHTVNAQALLDMAAQVASGMAYLESQNFIH 132 Query: 125 RDLKPQNLLINRNGELKLADFGLARAFG---IPVRCYSAEVVTLWYRPPDVLFGAKLYST 181 RDL +N L+ N +K+ADFGLAR R A+ W P + + +S Sbjct: 133 RDLAARNCLVGENNVVKVADFGLARLINEDEYTARA-GAKFPIKWTAPEAISY--NRFSI 189 Query: 182 SIDMWSAGCIFAELANAGRPLFP---GNDVDDQLKRIFRL 218 D+W+ G + E+ G+ +P G++V +Q++R +R+ Sbjct: 190 KSDVWAFGILLWEIFTYGQVPYPGMSGSEVIEQVERGYRM 229 >2UV2-A nrPDB Length = 325 Score = 93.6 bits (231), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 73/292 (25%), Positives = 135/292 (46%), Gaps = 40/292 (13%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 +E + ++G+G +G V+KA+N+ET + A K + D E + EI +L H NI Sbjct: 39 WEIIGELGDGAFGKVYKAQNKETSVLAAAKVI--DTKSEEELEDYMVEIDILASCDHPNI 96 Query: 64 VRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLF----QLLKGLGFCHS 119 V+L D + + L ++ EFC D+ +L+ + +S + Q L L + H Sbjct: 97 VKLLDAFYYENNLWILIEFC---AGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHD 153 Query: 120 RNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLF----G 175 ++HRDLK N+L +G++KLADFG++ ++ + + T ++ P+V+ Sbjct: 154 NKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSK 213 Query: 176 AKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPD 235 + Y D+WS G E+A P N + R+L + + P++ + Sbjct: 214 DRPYDYKADVWSLGITLIEMAEIEPPHHELNPM--------RVLLKIAKSEPPTLAQ--- 262 Query: 236 YKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFS 287 P+ + ++ +D L+ L+ N R + + LQHP+ + Sbjct: 263 -------PS---------RWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVT 298 >1U5R-A nrPDB Length = 348 Score = 92.8 bits (229), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 57/206 (27%), Positives = 97/206 (47%), Gaps = 7/206 (3%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVP-SSALREICLLKELKHKN 62 + L +IG G++G V+ A++ E+VA+K++ ++E+ L++L+H N Sbjct: 56 FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPN 115 Query: 63 IVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNV 122 ++ + LV E+C + L + + L+GL + HS N+ Sbjct: 116 TIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHSHNM 175 Query: 123 LHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAK--LYS 180 +HRD+K N+L++ G +KL DFG A P + V T ++ P+V+ Y Sbjct: 176 IHRDVKAGNILLSEPGLVKLGDFGSASIMA-PANSF---VGTPYWMAPEVILAMDEGQYD 231 Query: 181 TSIDMWSAGCIFAELANAGRPLFPGN 206 +D+WS G ELA PLF N Sbjct: 232 GKVDVWSLGITCIELAERKPPLFNMN 257 >5U6Y-A nrPDB Length = 461 Score = 92.8 bits (229), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 83/299 (27%), Positives = 136/299 (45%), Gaps = 54/299 (18%) Query: 4 YEKLEKIGEGTYGTVFK-----AKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKEL 58 Y+ E++G+G + V + A +I+ K++ D + RE + + L Sbjct: 2 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQK-----LEREARICRLL 56 Query: 59 KHKNIVRLHDVLHSDKKLTLVFE-------FCDQDLKKYFDSCNGDLDPEIVKSFLFQLL 111 KH NIVRLHD + + L+F+ F D ++Y+ + + Q+L Sbjct: 57 KHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADAS-------HCIQQIL 109 Query: 112 KGLGFCHSRNVLHRDLKPQNLLIN---RNGELKLADFGLARAFGIPVRCYSAEVVTLWYR 168 + + CH V+HRDLKP+NLL+ + +KLADFGLA + + T Y Sbjct: 110 EAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYL 169 Query: 169 PPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWP 228 P+VL Y +D+W+ G I L G P F D+ R+++ + + +P Sbjct: 170 SPEVL-RKDPYGKPVDLWACGVILYILL-VGYPPF----WDEDQHRLYQQIKAGAYD-FP 222 Query: 229 SMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFS 287 S P++ V P+ +DL+ +L NP +RI+A EAL+HP+ S Sbjct: 223 S----PEWD------------TVTPE----AKDLINKMLTINPSKRITAAEALKHPWIS 261 >5FG8-A nrPDB Length = 285 Score = 92.8 bits (229), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 81/297 (27%), Positives = 126/297 (42%), Gaps = 52/297 (17%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 Y+ E++G+G + V + + T A K + RE + ++L H NI Sbjct: 16 YDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHHPNI 75 Query: 64 VRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLF----------QLLKG 113 VRLHD + + LVF+ G+L +IV + Q+L+ Sbjct: 76 VRLHDSIQEENYHYLVFDLV----------TGGELFEDIVAREFYSEADASHCIQQILES 125 Query: 114 LGFCHSRNVLHRDLKPQNLLI---NRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPP 170 + CH V+HRDLKP+NLL+ + +KLADFGLA + + T Y P Sbjct: 126 VNHCHQNGVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSP 185 Query: 171 DVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSM 230 +VL + Y S+D+W+ G I L P + D+ R++ S Sbjct: 186 EVL-KKEPYGKSVDIWACGVILYILLVGYPPFW-----DEDQHRLY------------SQ 227 Query: 231 TKLPDYK-PYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286 K Y P P + T ++L+ +L NP +RI+A EAL+HP+ Sbjct: 228 IKAGAYDYPSPEWDTVTP----------EAKNLINQMLTVNPNKRITAAEALKHPWI 274 >2VZ6-A nrPDB Length = 313 Score = 92.4 bits (228), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 81/299 (27%), Positives = 135/299 (45%), Gaps = 54/299 (18%) Query: 4 YEKLEKIGEGTYGTVFK-----AKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKEL 58 Y+ E++G+G + V + A +I+ K++ D + RE + + L Sbjct: 24 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQK-----LEREARICRLL 78 Query: 59 KHKNIVRLHDVLHSDKKLTLVFE-------FCDQDLKKYFDSCNGDLDPEIVKSFLFQLL 111 KH NIVRLHD + + L+F+ F D ++Y+ + + Q+L Sbjct: 79 KHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADAS-------HCIQQIL 131 Query: 112 KGLGFCHSRNVLHRDLKPQNLLIN---RNGELKLADFGLARAFGIPVRCYSAEVVTLWYR 168 + + CH V+HRDLKP+NLL+ + +KLADFGLA + + T Y Sbjct: 132 EAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYL 191 Query: 169 PPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWP 228 P+VL Y +D+W+ G I L P + D+ R+++ + + +P Sbjct: 192 SPEVL-RKDPYGKPVDLWACGVILYILLVGYPPFW-----DEDQHRLYQQIKAGAYD-FP 244 Query: 229 SMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFS 287 S P++ V P+ +DL+ +L NP +RI+A EAL+HP+ S Sbjct: 245 S----PEWD------------TVTPE----AKDLINKMLTINPSKRITAAEALKHPWIS 283 >2GCD-A nrPDB Length = 309 Score = 92.4 bits (228), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 57/206 (27%), Positives = 97/206 (47%), Gaps = 7/206 (3%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVP-SSALREICLLKELKHKN 62 + L +IG G++G V+ A++ E+VA+K++ ++E+ L++L+H N Sbjct: 17 FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPN 76 Query: 63 IVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNV 122 ++ + LV E+C + L + + L+GL + HS N+ Sbjct: 77 TIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHSHNM 136 Query: 123 LHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAK--LYS 180 +HRD+K N+L++ G +KL DFG A P + V T ++ P+V+ Y Sbjct: 137 IHRDVKAGNILLSEPGLVKLGDFGSASIMA-PANSF---VGTPYWMAPEVILAMDEGQYD 192 Query: 181 TSIDMWSAGCIFAELANAGRPLFPGN 206 +D+WS G ELA PLF N Sbjct: 193 GKVDVWSLGITCIELAERKPPLFNMN 218 >6E2O-A nrPDB Length = 295 Score = 92.4 bits (228), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 69/243 (28%), Positives = 110/243 (45%), Gaps = 25/243 (10%) Query: 10 IGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDV 69 +G+GTYG V+ ++ +A+K + D P EI L K LKHKNIV+ Sbjct: 30 LGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLH--EEIALHKHLKHKNIVQYLGS 87 Query: 70 LHSDKKLTLVFEFC-DQDLKKYFDSCNGDL--DPEIVKSFLFQLLKGLGFCHSRNVLHRD 126 + + + E L S G L + + + + Q+L+GL + H ++HRD Sbjct: 88 FSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRD 147 Query: 127 LKPQNLLINR-NGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVL-FGAKLYSTSID 184 +K N+LIN +G LK++DFG ++ C TL Y P+++ G + Y + D Sbjct: 148 IKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAAD 207 Query: 185 MWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPA 244 +WS GC E+A P + LG P +M K+ +K +P P Sbjct: 208 IWSLGCTIIEMATGKPPFYE--------------LGEPQ----AAMFKVGMFKVHPEIPE 249 Query: 245 TTS 247 + S Sbjct: 250 SMS 252 >2JC6-A nrPDB Length = 334 Score = 91.7 bits (226), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 78/289 (26%), Positives = 132/289 (45%), Gaps = 36/289 (12%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 +E E +G G + V A+ + T ++ A+K + +G SS EI +L+++KH+NI Sbjct: 24 FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIP-KKALKGKESSIENEIAVLRKIKHENI 82 Query: 64 VRLHDVLHSDKKLTLVFEFCDQDLKKYFDSC--NGDLDPEIVKSFLFQLLKGLGFCHSRN 121 V L D+ S L LV + + FD G + + + Q+L + + H Sbjct: 83 VALEDIYESPNHLYLVMQLVSGG--ELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMG 140 Query: 122 VLHRDLKPQNLLI---NRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL 178 ++HRDLKP+NLL + ++ ++DFGL++ G S T Y P+VL K Sbjct: 141 IVHRDLKPENLLYYSQDEESKIMISDFGLSKMEG-KGDVMSTACGTPGYVAPEVL-AQKP 198 Query: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKP 238 YS ++D WS G I L P + ND K ++L E P + D Sbjct: 199 YSKAVDCWSIGVIAYILLCGYPPFYDENDS----KLFEQILKAEYEFDSPYWDDISD--- 251 Query: 239 YPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFS 287 + +D ++NL++ +P +R + E+A +HP+ + Sbjct: 252 -------------------SAKDFIRNLMEKDPNKRYTCEQAARHPWIA 281 >2Y7J-A nrPDB Length = 365 Score = 91.3 bits (225), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 85/299 (28%), Positives = 140/299 (46%), Gaps = 43/299 (14%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRET-HE----IVALKRVRLDDDD-EGVPSSALREICLL 55 QKY+ + IG G V + +R T HE I+ + RL + E V + RE +L Sbjct: 94 QKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHIL 153 Query: 56 KELK-HKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGD--LDPEIVKSFLFQLLK 112 +++ H +I+ L D S + LVF+ + + FD L + +S + LL+ Sbjct: 154 RQVAGHPHIITLIDSYESSSFMFLVFDLMRKG--ELFDYLTEKVALSEKETRSIMRSLLE 211 Query: 113 GLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDV 172 + F H+ N++HRDLKP+N+L++ N +++L+DFG + P T Y P++ Sbjct: 212 AVSFLHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHLE-PGEKLRELCGTPGYLAPEI 270 Query: 173 LFGAK-----LYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQW 227 L + Y +D+W+ G I L AG P F +R +L E Q+ Sbjct: 271 LKCSMDETHPGYGKEVDLWACGVILFTLL-AGSPPF-------WHRRQILMLRMIMEGQY 322 Query: 228 PSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286 + P + +S V +DL+ LL+ +P R++AE+ALQHP+F Sbjct: 323 QFSS--------PEWDDRSSTV----------KDLISRLLQVDPEARLTAEQALQHPFF 363 >3GUB-A nrPDB Length = 295 Score = 91.3 bits (225), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 81/300 (27%), Positives = 133/300 (44%), Gaps = 56/300 (18%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVA---LKRVRLDDDDEGVPSSAL-REICLLKELK 59 Y+ E++G G + V K + + T A +K+ R GV + RE+ +LKE++ Sbjct: 13 YDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEIQ 72 Query: 60 HKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 H N++ LH+V + + L+ E F + L E FL Q+L G+ + HS Sbjct: 73 HPNVITLHEVYENKTDVILIGELVAGGELFDFLAEKESLTEEEATEFLKQILNGVYYLHS 132 Query: 120 RNVLHRDLKPQN-LLINRNG---ELKLADFGLARA----------FGIPVRCYSAEVVTL 165 + H DLKP+N +L++RN +K+ DFGLA FG P + E+V Sbjct: 133 LQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTP-EFVAPEIVN- 190 Query: 166 WYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEE 225 Y P DMWS G I L + P LG +E Sbjct: 191 -YEP---------LGLEADMWSIGVITYILLSGASP----------------FLGDTKQE 224 Query: 226 QWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPY 285 +++ + +Y+ Y + TS A +D ++ LL +P +R++ +++LQHP+ Sbjct: 225 TLANVSAV-NYEFEDEYFSNTS---------ALAKDFIRRLLVKDPKKRMTIQDSLQHPW 274 >5D9K-A nrPDB Length = 330 Score = 91.3 bits (225), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 87/301 (28%), Positives = 141/301 (46%), Gaps = 55/301 (18%) Query: 3 KYEKLEKIGEGTYGTVFKAKN------RETHEIVALKRVRLDDDDEGVPSSALREICLLK 56 ++E L+ +G+G++G VF K R+ + + LK+ L D V + R+I L Sbjct: 31 QFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDR-VRTKMERDI--LV 87 Query: 57 ELKHKNIVRLHDVLHSDKKLTLVFEFC-DQDLKKYFDSCNGDL--DPEIVKSFLFQLLKG 113 E+ H IV+LH ++ KL L+ +F DL F + ++ E VK +L +L Sbjct: 88 EVNHPFIVKLHYAFQTEGKLYLILDFLRGGDL---FTRLSKEVMFTEEDVKFYLAELALA 144 Query: 114 LGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLAR-AFGIPVRCYSAEVVTLWYRPPDV 172 L HS +++RDLKP+N+L++ G +KL DFGL++ + + YS T+ Y P+V Sbjct: 145 LDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSF-CGTVEYMAPEV 203 Query: 173 LFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRL-LGTPTEEQWPSMT 231 + + ++ S D WS G + E+ P F G D + + I + LG P Q+ Sbjct: 204 V-NRRGHTQSADWWSFGVLMFEMLTGTLP-FQGKDRKETMTMILKAKLGMP---QF---- 254 Query: 232 KLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISA-----EEALQHPYF 286 L+ + LL+ L K NP R+ A EE +H +F Sbjct: 255 -----------------------LSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFF 291 Query: 287 S 287 S Sbjct: 292 S 292 >3SOA-A nrPDB Length = 444 Score = 90.9 bits (224), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 80/301 (26%), Positives = 136/301 (45%), Gaps = 54/301 (17%) Query: 2 QKYEKLEKIGEGTYGTVFK-----AKNRETHEIVALKRVRLDDDDEGVPSSALREICLLK 56 ++Y+ E++G+G + V + A I+ K++ D + RE + + Sbjct: 11 EEYQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDHQK-----LEREARICR 65 Query: 57 ELKHKNIVRLHDVLHSDKKLTLVFE-------FCDQDLKKYFDSCNGDLDPEIVKSFLFQ 109 LKH NIVRLHD + + L+F+ F D ++Y+ + + Q Sbjct: 66 LLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADAS-------HCIQQ 118 Query: 110 LLKGLGFCHSRNVLHRDLKPQNLLIN---RNGELKLADFGLARAFGIPVRCYSAEVVTLW 166 +L+ + CH V+HR+LKP+NLL+ + +KLADFGLA + + T Sbjct: 119 ILEAVLHCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPG 178 Query: 167 YRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQ 226 Y P+VL Y +D+W+ G I L P + D+ R+++ + + Sbjct: 179 YLSPEVL-RKDPYGKPVDLWACGVILYILLVGYPPFW-----DEDQHRLYQQIKAGAYD- 231 Query: 227 WPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286 +PS P++ V P+ +DL+ +L NP +RI+A EAL+HP+ Sbjct: 232 FPS----PEWD------------TVTPE----AKDLINKMLTINPSKRITAAEALKHPWI 271 Query: 287 S 287 S Sbjct: 272 S 272 >5KKR-C nrPDB Length = 395 Score = 90.5 bits (223), Expect = 8e-19, Method: Compositional matrix adjust. Identities = 62/208 (29%), Positives = 106/208 (50%), Gaps = 17/208 (8%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 +EK+ ++G G G VFK ++ + ++A K + L+ + + +RE+ +L E I Sbjct: 70 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKP-AIRNQIIRELQVLHECNSPYI 128 Query: 64 VRLHDVLHSDKKLTLVFEFCD-----QDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCH 118 V + +SD ++++ E D Q LKK G + +I+ ++KGL + Sbjct: 129 VGFYGAFYSDGEISICMEHMDGGSLDQVLKKA-----GRIPEQILGKVSIAVIKGLTYLR 183 Query: 119 SRN-VLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVV-TLWYRPPDVLFGA 176 ++ ++HRD+KP N+L+N GE+KL DFG++ G + + V T Y P+ L G Sbjct: 184 EKHKIMHRDVKPSNILVNSRGEIKLCDFGVS---GQLIDSMANSFVGTRSYMSPERLQGT 240 Query: 177 KLYSTSIDMWSAGCIFAELANAGRPLFP 204 YS D+WS G E+A P+ P Sbjct: 241 H-YSVQSDIWSMGLSLVEMAVGRYPIPP 267 >3BHH-A nrPDB Length = 295 Score = 90.1 bits (222), Expect = 9e-19, Method: Compositional matrix adjust. Identities = 81/293 (27%), Positives = 124/293 (42%), Gaps = 44/293 (15%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62 +Y+ E IG+G + V + T A K + RE + + LKH N Sbjct: 5 EYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSN 64 Query: 63 IVRLHDVLHSDKKLTLVFE-------FCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLG 115 IVRLHD + + LVF+ F D ++Y+ + + Q+L+ + Sbjct: 65 IVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADAS-------HCIQQILEAVL 117 Query: 116 FCHSRNVLHRDLKPQNLLIN---RNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDV 172 CH V+HRDLKP+NLL+ + +KLADFGLA + + T Y P+V Sbjct: 118 HCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEV 177 Query: 173 LFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTK 232 L + Y +D+W+ G I L G P F D ++I +W ++T Sbjct: 178 L-RKEAYGKPVDIWACGVILYILL-VGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVT- 234 Query: 233 LPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPY 285 P +L+N +L NP +RI+A EAL+HP+ Sbjct: 235 ----------PEAKNLIN--------------QMLTINPAKRITAHEALKHPW 263 >3UC3-A nrPDB Length = 361 Score = 90.1 bits (222), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 63/222 (28%), Positives = 107/222 (48%), Gaps = 8/222 (3%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62 +Y+ ++ IG G +G +++ T E+VA+K + + + + REI + L+H N Sbjct: 21 RYDFVKDIGSGNFGVARLMRDKLTKELVAVKYI---ERGAAIDENVQREIINHRSLRHPN 77 Query: 63 IVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCN-GDLDPEIVKSFLFQLLKGLGFCHSRN 121 IVR +V+ + L ++ E+ + Y CN G + + F QLL G+ +CHS Sbjct: 78 IVRFKEVILTPTHLAIIMEYASGG-ELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQ 136 Query: 122 VLHRDLKPQNLLINRN--GELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLY 179 + HRDLK +N L++ + LK+ DFG +++ + + S V T Y P+VL + Sbjct: 137 ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKST-VGTPAYIAPEVLLRQEYD 195 Query: 180 STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGT 221 D+WS G + P + D K I R+L Sbjct: 196 GKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSV 237 >1TKI-A nrPDB Length = 321 Score = 89.7 bits (221), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 70/288 (24%), Positives = 128/288 (44%), Gaps = 34/288 (11%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 +KY E +G G +G V + + + K V++ D+ + +EI +L +H+ Sbjct: 5 EKYMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVKGTDQVLVK---KEISILNIARHR 61 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 NI+ LH+ S ++L ++FEF D+ + ++ +L+ + S++ Q+ + L F HS Sbjct: 62 NILHLHESFESMEELVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCEALQFLHSH 121 Query: 121 NVLHRDLKPQNLL--INRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL 178 N+ H D++P+N++ R+ +K+ +FG AR P + Y P+V + Sbjct: 122 NIGHFDIRPENIIYQTRRSSTIKIIEFGQARQLK-PGDNFRLLFTAPEYYAPEV-HQHDV 179 Query: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKP 238 ST+ DMWS G + L + P + ++ I T EE + Sbjct: 180 VSTATDMWSLGTLVYVLLSGINPFLAETN-QQIIENIMNAEYTFDEEAF----------- 227 Query: 239 YPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286 +++ D + LL R++A EALQHP+ Sbjct: 228 --------------KEISIEAMDFVDRLLVKERKSRMTASEALQHPWL 261 >4RLP-A nrPDB Length = 288 Score = 89.7 bits (221), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 76/295 (25%), Positives = 126/295 (42%), Gaps = 45/295 (15%) Query: 4 YEKLEKIGEGTYGTVF---KAKNRETHEIVALKRVR----LDDDDEGVPSSALREICLLK 56 +E L +G+G YG VF K T +I A+K ++ + + + + A R I L+ Sbjct: 7 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNI--LE 64 Query: 57 ELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGF 116 E+KH IV L + KL L+ E+ G + +L ++ LG Sbjct: 65 EVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGH 124 Query: 117 CHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGA 176 H + +++RDLKP+N+++N G +KL DFGL + T+ Y P++L + Sbjct: 125 LHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRS 184 Query: 177 KLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDY 236 ++ ++D WS G + ++ G P F G + + +I + Sbjct: 185 G-HNRAVDWWSLGALMYDMLT-GAPPFTGENRKKTIDKILK------------------- 223 Query: 237 KPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRIS-----AEEALQHPYF 286 +N+ P L RDLL+ LLK N R+ A E HP+F Sbjct: 224 ----------CKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFF 268 >3EQC-A nrPDB Length = 360 Score = 89.7 bits (221), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 62/208 (29%), Positives = 106/208 (50%), Gaps = 17/208 (8%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 +EK+ ++G G G VFK ++ + ++A K + L+ + + +RE+ +L E I Sbjct: 35 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKP-AIRNQIIRELQVLHECNSPYI 93 Query: 64 VRLHDVLHSDKKLTLVFEFCD-----QDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCH 118 V + +SD ++++ E D Q LKK G + +I+ ++KGL + Sbjct: 94 VGFYGAFYSDGEISICMEHMDGGSLDQVLKK-----AGRIPEQILGKVSIAVIKGLTYLR 148 Query: 119 SRN-VLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVV-TLWYRPPDVLFGA 176 ++ ++HRD+KP N+L+N GE+KL DFG++ G + + V T Y P+ L G Sbjct: 149 EKHKIMHRDVKPSNILVNSRGEIKLCDFGVS---GQLIDSMANSFVGTRSYMSPERLQGT 205 Query: 177 KLYSTSIDMWSAGCIFAELANAGRPLFP 204 YS D+WS G E+A P+ P Sbjct: 206 H-YSVQSDIWSMGLSLVEMAVGRYPIPP 232 >4EQM-A nrPDB Length = 294 Score = 89.7 bits (221), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 64/207 (30%), Positives = 108/207 (52%), Gaps = 6/207 (2%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLD-DDDEGVPSSALREICLLKELKH 60 ++Y+ ++K+G G TV+ A++ + VA+K + + + E RE+ +L H Sbjct: 11 ERYKIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETLKRFEREVHNSSQLSH 70 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 +NIV + DV D LV E+ + L +Y +S +G L + +F Q+L G+ H Sbjct: 71 QNIVSMIDVDEEDDCYYLVMEYIEGPTLSEYIES-HGPLSVDTAINFTNQILDGIKHAHD 129 Query: 120 RNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVV-TLWYRPPDVLFGAKL 178 ++HRD+KPQN+LI+ N LK+ DFG+A+A + V+ T+ Y P+ G Sbjct: 130 MRIVHRDIKPQNILIDSNKTLKIFDFGIAKALSETSLTQTNHVLGTVQYFSPEQAKGEAT 189 Query: 179 YSTSIDMWSAGCIFAELANAGRPLFPG 205 + D++S G + E+ G P F G Sbjct: 190 DECT-DIYSIGIVLYEML-VGEPPFNG 214 >4L42-A nrPDB Length = 346 Score = 89.7 bits (221), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 76/295 (25%), Positives = 126/295 (42%), Gaps = 45/295 (15%) Query: 4 YEKLEKIGEGTYGTVF---KAKNRETHEIVALKRVR----LDDDDEGVPSSALREICLLK 56 +E L +G+G YG VF K T +I A+K ++ + + + + A R I L+ Sbjct: 20 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNI--LE 77 Query: 57 ELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGF 116 E+KH IV L + KL L+ E+ G + +L ++ LG Sbjct: 78 EVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGH 137 Query: 117 CHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGA 176 H + +++RDLKP+N+++N G +KL DFGL + T+ Y P++L + Sbjct: 138 LHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRS 197 Query: 177 KLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDY 236 ++ ++D WS G + ++ G P F G + + +I + Sbjct: 198 G-HNRAVDWWSLGALMYDMLT-GAPPFTGENRKKTIDKILK------------------- 236 Query: 237 KPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRIS-----AEEALQHPYF 286 +N+ P L RDLL+ LLK N R+ A E HP+F Sbjct: 237 ----------CKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFF 281 >2J90-A nrPDB Length = 304 Score = 89.4 bits (220), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 78/301 (25%), Positives = 132/301 (43%), Gaps = 56/301 (18%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVA---LKRVRLDDDDEGVPSSAL-REICLLKELK 59 YE E++G G + V K + + T + A +K+ RL GV + RE+ +L+E++ Sbjct: 28 YEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILREIR 87 Query: 60 HKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 H NI+ LHD+ + + L+ E F + L + FL Q+L G+ + HS Sbjct: 88 HPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDGVHYLHS 147 Query: 120 RNVLHRDLKPQN-LLINRNG---ELKLADFGLARA----------FGIPVRCYSAEVVTL 165 + + H DLKP+N +L+++N +KL DFG+A FG P + E+V Sbjct: 148 KRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTP-EFVAPEIVN- 205 Query: 166 WYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEE 225 Y P DMWS G I L + P LG +E Sbjct: 206 -YEP---------LGLEADMWSIGVITYILLSGASP----------------FLGETKQE 239 Query: 226 QWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPY 285 +++ + +Y Y + TS +D ++ LL +P +R++ ++L+H + Sbjct: 240 TLTNISAV-NYDFDEEYFSNTS---------ELAKDFIRRLLVKDPKRRMTIAQSLEHSW 289 Query: 286 F 286 Sbjct: 290 I 290 >4AN9-A nrPDB Length = 301 Score = 89.0 bits (219), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 81/290 (27%), Positives = 131/290 (45%), Gaps = 45/290 (15%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 +EK+ ++G G G VFK ++ + ++A K + L+ + + +RE+ +L E I Sbjct: 11 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIK-PAIRNQIIRELQVLHECNSPYI 69 Query: 64 VRLHDVLHSDKKLTLVFEFCD-----QDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCH 118 V + +SD ++++ E D Q LKK G + +I+ ++KGL + Sbjct: 70 VGFYGAFYSDGEISICMEHMDGGSLDQVLKK-----AGRIPEQILGKVSIAVIKGLTYLR 124 Query: 119 SRN-VLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVV-TLWYRPPDVLFGA 176 ++ ++HRD+KP N+L+N GE+KL DFG++ G + + E V T Y P+ L G Sbjct: 125 EKHKIMHRDVKPSNILVNSRGEIKLCDFGVS---GQLIDEMANEFVGTRSYMSPERLQGT 181 Query: 177 KLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDY 236 YS D+WS G E+A P P IF LL E P KLP Sbjct: 182 H-YSVQSDIWSMGLSLVEMAVGRYPRPP--------MAIFELLDYIVNEPPP---KLPS- 228 Query: 237 KPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286 A SL +D + L NP +R ++ + H + Sbjct: 229 -------AVFSL---------EFQDFVNKCLIKNPAERADLKQLMVHAFI 262 >5F9E-A nrPDB Length = 353 Score = 89.0 bits (219), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 75/294 (25%), Positives = 137/294 (46%), Gaps = 40/294 (13%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLD----DDDEGVPSSALREICLLK 56 ++ +E + +G+G++G VF A+ ++T++ A+K ++ D DDD V + + + L Sbjct: 18 IEDFELHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDD--VECTMVEKRVLSL 75 Query: 57 ELKHKNIVRLHDVLHSDKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFLFQLLKGLG 115 +H + + + + L V E+ + DL + SC+ D + +++ GL Sbjct: 76 AWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCH-KFDLSRATFYAAEIILGLQ 134 Query: 116 FCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFG 175 F HS+ +++RDLK N+L++++G +K+ADFG+ + + + T Y P++L G Sbjct: 135 FLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNEFCGTPDYIAPEILLG 194 Query: 176 AKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPD 235 K Y+ S+D WS G + E+ P F G D EE+ ++ + Sbjct: 195 QK-YNHSVDWWSFGVLLYEMLIGQSP-FHGQD----------------EEELFHSIRMDN 236 Query: 236 YKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAE-EALQHPYFSD 288 P YP L +DLL L P +R+ + QHP F + Sbjct: 237 ----PFYPRW---------LEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFRE 277 >3QA8-A nrPDB Length = 676 Score = 88.6 bits (218), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 67/217 (30%), Positives = 110/217 (50%), Gaps = 23/217 (10%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALR---EICLLKELKH 60 +E E++G G +G V + +++T E VA+K+ R E P + R EI ++K+L H Sbjct: 16 WEMKERLGTGGFGYVLRWIHQDTGEQVAIKQCR----QELSPKNRERWCLEIQIMKKLNH 71 Query: 61 KNIVRLHDVLHSDKKLT------LVFEFCDQ-DLKKY---FDSCNGDLDPEIVKSFLFQL 110 N+V +V +KL L E+C+ DL+KY F++C G L +++ L + Sbjct: 72 PNVVSAREVPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCG-LKEGPIRTLLSDI 130 Query: 111 LKGLGFCHSRNVLHRDLKPQNLLINRNGEL---KLADFGLARAFGIPVRCYSAEVVTLWY 167 L + H ++HRDLKP+N+++ + K+ D G A+ C + V TL Y Sbjct: 131 SSALRYLHENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQGELC-TEFVGTLQY 189 Query: 168 RPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFP 204 P++L K Y+ ++D WS G + E RP P Sbjct: 190 LAPELLEQKK-YTVTVDYWSFGTLAFECITGFRPFLP 225 >2X4F-A nrPDB Length = 373 Score = 88.6 bits (218), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 79/289 (27%), Positives = 128/289 (44%), Gaps = 39/289 (13%) Query: 6 KLEKIGEGTYGTVFKAKNRETHEIVALK--RVRLDDDDEGVPSSALREICLLKELKHKNI 63 K E +G G +G V K + T +A K + R D E V + EI ++ +L H N+ Sbjct: 93 KTEILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKEEVKN----EISVMNQLDHANL 148 Query: 64 VRLHDVLHSDKKLTLVFEFCD--QDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN 121 ++L+D S + LV E+ D + + D + + + F+ Q+ +G+ H Sbjct: 149 IQLYDAFESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTI-LFMKQICEGIRHMHQMY 207 Query: 122 VLHRDLKPQNLL-INRNG-ELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLY 179 +LH DLKP+N+L +NR+ ++K+ DFGLAR + P T + P+V+ Sbjct: 208 ILHLDLKPENILCVNRDAKQIKIIDFGLARRYK-PREKLKVNFGTPEFLAPEVV-NYDFV 265 Query: 180 STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPY 239 S DMWS G I L + P ND + L I +E++ +++ Sbjct: 266 SFPTDMWSVGVIAYMLLSGLSPFLGDNDAE-TLNNILACRWDLEDEEFQDISE------- 317 Query: 240 PMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288 ++ + LL RISA EAL+HP+ SD Sbjct: 318 ------------------EAKEFISKLLIKEKSWRISASEALKHPWLSD 348 >2W4O-A nrPDB Length = 349 Score = 88.2 bits (217), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 76/293 (25%), Positives = 131/293 (44%), Gaps = 46/293 (15%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 +E ++G G V++ K + T + ALK ++ D + V + EI +L L H NI Sbjct: 55 FEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKIVRT----EIGVLLRLSHPNI 110 Query: 64 VRLHDVLHSDKKLTLVFEFC------DQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFC 117 ++L ++ + +++LV E D+ ++K + S D + Q+L+ + + Sbjct: 111 IKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADA------VKQILEAVAYL 164 Query: 118 HSRNVLHRDLKPQNLLINR---NGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLF 174 H ++HRDLKP+NLL + LK+ADFGL++ V + T Y P++L Sbjct: 165 HENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTV-CGTPGYCAPEILR 223 Query: 175 GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLP 234 G Y +DMWS G I L P + +RI W ++ Sbjct: 224 GCA-YGPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVS--- 279 Query: 235 DYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFS 287 LNA +DL++ L+ +P +R++ +ALQHP+ + Sbjct: 280 --------------------LNA--KDLVRKLIVLDPKKRLTTFQALQHPWVT 310 >2JAM-A nrPDB Length = 304 Score = 88.2 bits (217), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 76/286 (26%), Positives = 127/286 (44%), Gaps = 42/286 (14%) Query: 7 LEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRL 66 +E +G G + VF K R T ++ ALK ++ SS EI +LK++KH+NIV L Sbjct: 14 MEVLGSGAFSEVFLVKQRLTGKLFALKCIK--KSPAFRDSSLENEIAVLKKIKHENIVTL 71 Query: 67 HDVLHSDKKLTLVFEFCDQDLKKYFDSC--NGDLDPEIVKSFLFQLLKGLGFCHSRNVLH 124 D+ S LV + + FD G + + Q+L + + H ++H Sbjct: 72 EDIYESTTHYYLVMQLVSGG--ELFDRILERGVYTEKDASLVIQQVLSAVKYLHENGIVH 129 Query: 125 RDLKPQNLLI---NRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYST 181 RDLKP+NLL N ++ + DFGL++ + S T Y P+VL K YS Sbjct: 130 RDLKPENLLYLTPEENSKIMITDFGLSKMEQNGIM--STACGTPGYVAPEVL-AQKPYSK 186 Query: 182 SIDMWSAGCIFAELANAGRPLFPGNDVD--DQLKRIFRLLGTPTEEQWPSMTKLPDYKPY 239 ++D WS G I L P + + +++K + +P W +++ Sbjct: 187 AVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPF---WDDISE------- 236 Query: 240 PMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPY 285 + +D + +LL+ +P +R + E+AL HP+ Sbjct: 237 ------------------SAKDFICHLLEKDPNERYTCEKALSHPW 264 >2XIK-A nrPDB Length = 294 Score = 87.8 bits (216), Expect = 5e-18, Method: Compositional matrix adjust. Identities = 77/269 (28%), Positives = 132/269 (49%), Gaps = 28/269 (10%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 + KL++IG+G++G V+K + T E+VA+K + L++ ++ + +EI +L + I Sbjct: 21 FTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQ-QEITVLSQCDSPYI 79 Query: 64 VRLHDVLHSDKKLTLVFEFCDQ----DLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 R KL ++ E+ DL K G L+ + + L ++LKGL + HS Sbjct: 80 TRYFGSYLKSTKLWIIMEYLGGGSALDLLK-----PGPLEETYIATILREILKGLDYLHS 134 Query: 120 RNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLY 179 +HRD+K N+L++ G++KLADFG+A + V T ++ P+V+ Y Sbjct: 135 ERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI-KQSAY 193 Query: 180 STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLL---GTPTEEQWPSMTKLPDY 236 D+WS G ELA G P P +D+ R+ L+ PT E S Sbjct: 194 DFKADIWSLGITAIELAK-GEP--PNSDLHPM--RVLFLIPKNSPPTLEGQHS------- 241 Query: 237 KPYPMYPATTSLVNVVPKLNATGRDLLQN 265 KP+ + + +N P+ T ++LL++ Sbjct: 242 KPFKEF--VEACLNKDPRFRPTAKELLKH 268 >2Z7Q-A nrPDB Length = 321 Score = 87.8 bits (216), Expect = 5e-18, Method: Compositional matrix adjust. Identities = 85/300 (28%), Positives = 140/300 (46%), Gaps = 55/300 (18%) Query: 4 YEKLEKIGEGTYGTVF------KAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKE 57 +E L+ +G+G++G VF + + + + LK+ L D V + R+I L + Sbjct: 30 FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDR-VRTKMERDI--LAD 86 Query: 58 LKHKNIVRLHDVLHSDKKLTLVFEFC-DQDLKKYFDSCNGDL--DPEIVKSFLFQLLKGL 114 + H +V+LH ++ KL L+ +F DL F + ++ E VK +L +L GL Sbjct: 87 VNHPFVVKLHYAFQTEGKLYLILDFLRGGDL---FTRLSKEVMFTEEDVKFYLAELALGL 143 Query: 115 GFCHSRNVLHRDLKPQNLLINRNGELKLADFGLAR-AFGIPVRCYSAEVVTLWYRPPDVL 173 HS +++RDLKP+N+L++ G +KL DFGL++ A + YS T+ Y P+V+ Sbjct: 144 DHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSF-CGTVEYMAPEVV 202 Query: 174 FGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRL-LGTPTEEQWPSMTK 232 + +S S D WS G + E+ P F G D + + I + LG P Q+ Sbjct: 203 -NRQGHSHSADWWSYGVLMFEMLTGSLP-FQGKDRKETMTLILKAKLGMP---QF----- 252 Query: 233 LPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRI-----SAEEALQHPYFS 287 L+ + LL+ L K NP R+ AEE +H ++S Sbjct: 253 ----------------------LSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYS 290 >1S9I-A nrPDB Length = 354 Score = 87.8 bits (216), Expect = 5e-18, Method: Compositional matrix adjust. Identities = 59/203 (29%), Positives = 101/203 (49%), Gaps = 7/203 (3%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 +E++ ++G G G V K ++R + I+A K + L+ + + +RE+ +L E I Sbjct: 18 FERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKP-AIRNQIIRELQVLHECNSPYI 76 Query: 64 VRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN-V 122 V + +SD ++++ E D + EI+ +L+GL + ++ + Sbjct: 77 VGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREKHQI 136 Query: 123 LHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVV-TLWYRPPDVLFGAKLYST 181 +HRD+KP N+L+N GE+KL DFG++ G + + V T Y P+ L G YS Sbjct: 137 MHRDVKPSNILVNSRGEIKLCDFGVS---GQLIDSMANSFVGTRSYMAPERLQGTH-YSV 192 Query: 182 SIDMWSAGCIFAELANAGRPLFP 204 D+WS G ELA P+ P Sbjct: 193 QSDIWSMGLSLVELAVGRYPIPP 215 >5JZN-A nrPDB Length = 280 Score = 87.4 bits (215), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 81/292 (27%), Positives = 134/292 (45%), Gaps = 35/292 (11%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 ++Y+ IG+G + V + R T ALK ++ G E+ +L+ +KH Sbjct: 19 ERYKVGRTIGDGNFAVVKECVERSTAREYALKIIK-KSKCRGKEHMIQNEVSILRRVKHP 77 Query: 62 NIVRLHDVLHSDKKLTLVFEFC-DQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 NIV L + + +L LV E DL S N + + L+ L + + HS Sbjct: 78 NIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTNKYTERD-ASGMLYNLASAIKYLHSL 136 Query: 121 NVLHRDLKPQNLLI--NRNG--ELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGA 176 N++HRD+KP+NLL+ +++G LKL DFGLA P+ T Y P+++ Sbjct: 137 NIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGPLYTVCG---TPTYVAPEII-AE 192 Query: 177 KLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDY 236 Y +D+W+AG I L G P F G+ D ++ L+G + +PS Sbjct: 193 TGYGLKVDIWAAGVITYILL-CGFPPFRGSGDDQEVLFDQILMG---QVDFPS------- 241 Query: 237 KPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288 PY ++ + ++L+ +L + QR SA + L+HP+ +D Sbjct: 242 -PY------------WDNVSDSAKELITMMLLVDVDQRFSAVQVLEHPWVND 280 >2V7O-A nrPDB Length = 336 Score = 87.4 bits (215), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 77/293 (26%), Positives = 125/293 (42%), Gaps = 46/293 (15%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 Y+ E++G+G + V + + + A K + RE + + LKH NI Sbjct: 33 YQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 92 Query: 64 VRLHDVLHSDKKLTLVFE-------FCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGF 116 VRLHD + + LVF+ F D ++Y+ + + Q+L+ + Sbjct: 93 VRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADAS-------HCIHQILESVNH 145 Query: 117 CHSRNVLHRDLKPQNLLIN---RNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVL 173 H +++HRDLKP+NLL+ + +KLADFGLA + + T Y P+VL Sbjct: 146 IHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVL 205 Query: 174 FGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKL 233 Y +D+W+ G I L G P F D ++I K Sbjct: 206 -RKDPYGKPVDIWACGVILYILL-VGYPPFWDEDQHKLYQQI----------------KA 247 Query: 234 PDYK-PYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPY 285 Y P P + T ++L+ +L NP +RI+A++AL+HP+ Sbjct: 248 GAYDFPSPEWDTVTP----------EAKNLINQMLTINPAKRITADQALKHPW 290 >6NPU-A nrPDB Length = 298 Score = 87.4 bits (215), Expect = 7e-18, Method: Compositional matrix adjust. Identities = 59/214 (27%), Positives = 107/214 (50%), Gaps = 11/214 (5%) Query: 9 KIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHD 68 K+G G YG V++ ++ VA+K ++ +D L+E ++KE+KH N+V+L Sbjct: 33 KLGGGQYGEVYEGVWKKYSLTVAVKTLK---EDTMEVEEFLKEAAVMKEIKHPNLVQLLG 89 Query: 69 VLHSDKKLTLVFEFCDQ-DLKKYFDSCN-GDLDPEIVKSFLFQLLKGLGFCHSRNVLHRD 126 V + ++ EF +L Y CN +++ ++ Q+ + + +N +HRD Sbjct: 90 VCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRD 149 Query: 127 LKPQNLLINRNGELKLADFGLARAF-GIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDM 185 L +N L+ N +K+ADFGL+R G ++ + + P+ L K +S D+ Sbjct: 150 LAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNK-FSIKSDV 208 Query: 186 WSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLL 219 W+ G + E+A G +PG D L +++ LL Sbjct: 209 WAFGVLLWEIATYGMSPYPGID----LSQVYELL 238 >1ZXE-A nrPDB Length = 303 Score = 87.4 bits (215), Expect = 7e-18, Method: Compositional matrix adjust. Identities = 63/220 (28%), Positives = 107/220 (48%), Gaps = 31/220 (14%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 +E++ +G+G +G V KA+N A+K++R E S+ L E+ LL L H+ + Sbjct: 8 FEEIAVLGQGAFGQVVKARNALDSRYYAIKKIR---HTEEKLSTILSEVMLLASLNHQYV 64 Query: 64 VRLHDV----------LHSDKKLTLVF---EFCD-QDLKKYFDSCNGDLDPEIVKSFLFQ 109 VR + + + KK + +F E+C+ + L S N + + Q Sbjct: 65 VRYYAAWLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQRDEYWRLFRQ 124 Query: 110 LLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLA----RAFGI----------PV 155 +L+ L + HS+ ++HR+LKP N+ I+ + +K+ DFGLA R+ I Sbjct: 125 ILEALSYIHSQGIIHRNLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKLDSQNLPGSS 184 Query: 156 RCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAEL 195 ++ + T Y +VL G Y+ IDM+S G IF E+ Sbjct: 185 DNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEM 224 >3IS5-A nrPDB Length = 285 Score = 87.4 bits (215), Expect = 7e-18, Method: Compositional matrix adjust. Identities = 81/292 (27%), Positives = 126/292 (43%), Gaps = 52/292 (17%) Query: 9 KIGEGTYGTVFKAKNRETHEIVALKRV--RLDDDDEGVPSSALR-EICLLKELKHKNIVR 65 K+G G +G V + R + L+RV ++ D VP + EI +LK L H NI++ Sbjct: 29 KLGSGAFGDVHLVEERSS----GLERVIKTINKDRSQVPMEQIEAEIEVLKSLDHPNIIK 84 Query: 66 LHDVLHSDKKLTLVFEFCDQ-DLKKYFDSCNG---DLDPEIVKSFLFQLLKGLGFCHSRN 121 + +V + +V E C+ +L + S L V + Q++ L + HS++ Sbjct: 85 IFEVFEDYHNMYIVMETCEGGELLERIVSAQARGKALSEGYVAELMKQMMNALAYFHSQH 144 Query: 122 VLHRDLKPQNLLINR---NGELKLADFGLARAFGIPVRCYSAEVVTLWYRPP----DVLF 174 V+H+DLKP+N+L + +K+ DFGLA F +A L+ P DV F Sbjct: 145 VVHKDLKPENILFQDTSPHSPIKIIDFGLAELFKSDEHSTNAAGTALYMAPEVFKRDVTF 204 Query: 175 GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLP 234 D+WSAG + L P F G ++ E Q + K P Sbjct: 205 -------KCDIWSAGVVMYFLLTGCLP-FTGTSLE--------------EVQQKATYKEP 242 Query: 235 DYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286 +Y V P L DLL+ +L +P +R SA + L H +F Sbjct: 243 NYA-----------VECRP-LTPQAVDLLKQMLTKDPERRPSAAQVLHHEWF 282 >3KK8-A nrPDB Length = 284 Score = 87.0 bits (214), Expect = 8e-18, Method: Compositional matrix adjust. Identities = 77/298 (25%), Positives = 129/298 (43%), Gaps = 51/298 (17%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 Y+ E++G+G + V + ++ T A K + RE + ++L+H NI Sbjct: 8 YDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQHPNI 67 Query: 64 VRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLF----------QLLKG 113 VRLHD + + LVF+ G+L +IV + Q+L+ Sbjct: 68 VRLHDSIQEESFHYLVFDLV----------TGGELFEDIVAREFYSEADASHCIQQILES 117 Query: 114 LGFCHSRNVLHRDLKPQNLLI---NRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPP 170 + +CHS ++HR+LKP+NLL+ + +KLADFGLA + T Y P Sbjct: 118 IAYCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVN-DSEAWHGFAGTPGYLSP 176 Query: 171 DVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSM 230 +VL YS +D+W+ G I L P + D+ R++ + Sbjct: 177 EVL-KKDPYSKPVDIWACGVILYILLVGYPPFW-----DEDQHRLYAQIKAGAY------ 224 Query: 231 TKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288 DY P P + T + L+ ++L NP +RI+A++AL+ P+ + Sbjct: 225 ----DY-PSPEWDTVTP----------EAKSLIDSMLTVNPKKRITADQALKVPWICN 267 >4U41-A nrPDB Length = 332 Score = 87.0 bits (214), Expect = 9e-18, Method: Compositional matrix adjust. Identities = 64/214 (29%), Positives = 104/214 (48%), Gaps = 20/214 (9%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH-KN 62 +E +E +G GTYG V+K ++ +T ++ A+K + D E EI +LK+ H +N Sbjct: 26 FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVM---DVTEDEEEEIKLEINMLKKYSHHRN 82 Query: 63 IVRLHDVL------HSDKKLTLVFEFCD----QDLKKYFDSCNGDLDPEIVKSFLFQLLK 112 I + D +L LV EFC DL K ++ L + + ++L+ Sbjct: 83 IATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVK--NTKGNTLKEDWIAYISREILR 140 Query: 113 GLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDV 172 GL H +V+HRD+K QN+L+ N E+KL DFG++ V + + T ++ P+V Sbjct: 141 GLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEV 200 Query: 173 LFGAK----LYSTSIDMWSAGCIFAELANAGRPL 202 + + Y D+WS G E+A PL Sbjct: 201 IACDENPDATYDYRSDLWSCGITAIEMAEGAPPL 234 >4XEY-B nrPDB Length = 408 Score = 86.7 bits (213), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 59/214 (27%), Positives = 107/214 (50%), Gaps = 11/214 (5%) Query: 9 KIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHD 68 K+G G YG V++ ++ VA+K ++ D + L+E ++KE+KH N+V+L Sbjct: 132 KLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTME---VEEFLKEAAVMKEIKHPNLVQLLG 188 Query: 69 VLHSDKKLTLVFEFCDQ-DLKKYFDSCN-GDLDPEIVKSFLFQLLKGLGFCHSRNVLHRD 126 V + ++ EF +L Y CN +++ ++ Q+ + + +N +HRD Sbjct: 189 VCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRD 248 Query: 127 LKPQNLLINRNGELKLADFGLARAF-GIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDM 185 L +N L+ N +K+ADFGL+R G ++ + + P+ L K +S D+ Sbjct: 249 LAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNK-FSIKSDV 307 Query: 186 WSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLL 219 W+ G + E+A G +PG D L +++ LL Sbjct: 308 WAFGVLLWEIATYGMSPYPGID----LSQVYELL 337 >4FZF-B nrPDB Length = 283 Score = 86.7 bits (213), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 61/209 (29%), Positives = 108/209 (51%), Gaps = 14/209 (6%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 + KLE+IG+G++G VFK + T ++VA+K + L++ ++ + +EI +L + + Sbjct: 10 FTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQ-QEITVLSQCDSSYV 68 Query: 64 VRLHDVLHSDKKLTLVFEFCDQ----DLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 + + KL ++ E+ DL + G D + + L ++LKGL + HS Sbjct: 69 TKYYGSYLKGSKLWIIMEYLGGGSALDLLR-----AGPFDEFQIATMLKEILKGLDYLHS 123 Query: 120 RNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLY 179 +HRD+K N+L++ G++KLA FG+A + V T ++ P+V+ Y Sbjct: 124 EKKIHRDIKAANVLLSEQGDVKLAAFGVAGQLTDTQIKRNTFVGTPFWMAPEVI-QQSAY 182 Query: 180 STSIDMWSAGCIFAELANAGRPLFPGNDV 208 + D+WS G ELA G P P +D+ Sbjct: 183 DSKADIWSLGITAIELAK-GEP--PNSDM 208 >3RAW-A nrPDB Length = 381 Score = 86.7 bits (213), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 91/340 (26%), Positives = 145/340 (42%), Gaps = 66/340 (19%) Query: 2 QKYEKLEKIGEGTYGTVFKA-KNRETHEIVALKRVRLDDDDEGVPSSALR-EICLLKELK 59 ++YE + +GEGT+G V + + VALK +R + G A R EI +LK++K Sbjct: 51 ERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIR----NVGKYREAARLEINVLKKIK 106 Query: 60 HKN------IVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDP-EIVKSFLFQLLK 112 K+ V + D + + + FE ++ ++ N P V+ +QL Sbjct: 107 EKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCH 166 Query: 113 GLGFCHSRNVLHRDLKPQNLL-IN------------------RNGELKLADFGLARAFGI 153 L F H + H DLKP+N+L +N +N +++ADFG A Sbjct: 167 ALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSA---TF 223 Query: 154 PVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLK 213 ++ V T YRPP+V+ ++ D+WS GCI E G LF ++ + L Sbjct: 224 DHEHHTTIVATRHYRPPEVILELG-WAQPCDVWSIGCILFEYYR-GFTLFQTHENREHLV 281 Query: 214 RIFRLLGTPTEEQWPSMTKLPDY----------------------KPYPMYPATTSLVNV 251 + ++LG P T+ Y KP Y SL +V Sbjct: 282 MMEKILG-PIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHV 340 Query: 252 VPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCP 291 DL++ +L+ +P QRI+ EAL HP+F+ P Sbjct: 341 ------QLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTP 374 >2BDW-A nrPDB Length = 362 Score = 86.7 bits (213), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 79/296 (26%), Positives = 129/296 (43%), Gaps = 51/296 (17%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 Y+ E++G+G + V + ++ T A K + RE + ++L+H NI Sbjct: 31 YDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQHPNI 90 Query: 64 VRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLF----------QLLKG 113 VRLHD + + LVF+ G+L +IV + Q+L+ Sbjct: 91 VRLHDSIQEESFHYLVFDLV----------TGGELFEDIVAREFYSEADASHCIQQILES 140 Query: 114 LGFCHSRNVLHRDLKPQNLLI---NRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPP 170 + +CHS ++HR+LKP+NLL+ + +KLADFGLA + T Y P Sbjct: 141 IAYCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVN-DSEAWHGFAGTPGYLSP 199 Query: 171 DVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSM 230 +VL YS +D+W+ G I L G P F D+ R++ + Sbjct: 200 EVL-KKDPYSKPVDIWACGVILYILL-VGYPPF----WDEDQHRLYAQIKAGAY------ 247 Query: 231 TKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286 DY P P + T + L+ ++L NP +RI+A++AL+ P+ Sbjct: 248 ----DY-PSPEWDTVT----------PEAKSLIDSMLTVNPKKRITADQALKVPWI 288 >5DBX-A nrPDB Length = 328 Score = 86.3 bits (212), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 64/211 (30%), Positives = 99/211 (46%), Gaps = 14/211 (6%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 YE E IG G V A + E VA+KR+ L+ + L+EI + + H N+ Sbjct: 13 YELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSM-DELLKEIQAMSQCSHPNV 71 Query: 64 VRLHDVLHSDKKLTLVFEFCDQ----DLKKYF----DSCNGDLDPEIVKSFLFQLLKGLG 115 V + +L LV + D+ KY + NG L+ I+ + L ++L+GL Sbjct: 72 VTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGLD 131 Query: 116 FCHSRNVLHRDLKPQNLLINRNGELKLADFGLAR--AFGIPV---RCYSAEVVTLWYRPP 170 + H +HRDLK N+L+ +G +++ADFG++ A G V + V T + P Sbjct: 132 YLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKDFVGTPCWMAP 191 Query: 171 DVLFGAKLYSTSIDMWSAGCIFAELANAGRP 201 +V+ + Y DMWS G ELA P Sbjct: 192 EVMEQVRGYDFKADMWSFGITAIELATGAAP 222 >1AD5-A nrPDB Length = 438 Score = 86.3 bits (212), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 68/231 (29%), Positives = 112/231 (48%), Gaps = 28/231 (12%) Query: 6 KLEK-IGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSA-----LREICLLKELK 59 KLEK +G G +G V+ A + H VA+K ++ P S L E ++K L+ Sbjct: 185 KLEKKLGAGQFGEVWMATYNK-HTKVAVKTMK--------PGSMSVEAFLAEANVMKTLQ 235 Query: 60 HKNIVRLHDVLHSDKKLTLVFEFCDQ-DLKKYFDSCNGDLDP-EIVKSFLFQLLKGLGFC 117 H +V+LH V+ + + + ++ EF + L + S G P + F Q+ +G+ F Sbjct: 236 HDKLVKLHAVV-TKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFI 294 Query: 118 HSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAK 177 RN +HRDL+ N+L++ + K+ADFGLAR A+ W P + FG+ Sbjct: 295 EQRNYIHRDLRAANILVSASLVCKIADFGLARV--------GAKFPIKWTAPEAINFGS- 345 Query: 178 LYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWP 228 ++ D+WS G + E+ GR +PG + ++ + R P E P Sbjct: 346 -FTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCP 395 >3VN9-A nrPDB Length = 340 Score = 85.9 bits (211), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 75/295 (25%), Positives = 127/295 (43%), Gaps = 45/295 (15%) Query: 5 EKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI- 63 E + ++G G YG V K ++ + +I+A+KR+R V S + + + ++ + + Sbjct: 54 EPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRAT-----VNSQEQKRLLMDLDISMRTVD 108 Query: 64 ----VRLHDVLHSDKKLTLVFEFCDQDLKKYFDSC--NGDLDPE-IVKSFLFQLLKGLGF 116 V + L + + + E D L K++ G PE I+ ++K L Sbjct: 109 CPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEH 168 Query: 117 CHSR-NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVL-- 173 HS+ +V+HRD+KP N+LIN G++K+ DFG++ + + + + Y P+ + Sbjct: 169 LHSKLSVIHRDVKPSNVLINALGQVKMCDFGIS-GYLVDSVAKTIDAGCKPYMAPERINP 227 Query: 174 -FGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTK 232 K YS D+WS G ELA P QLK++ Sbjct: 228 ELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVE--------------- 272 Query: 233 LPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFS 287 +P P PA K +A D LK N +R + E +QHP+F+ Sbjct: 273 ----EPSPQLPAD--------KFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFT 315 >2A27-A nrPDB Length = 321 Score = 85.9 bits (211), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 77/302 (25%), Positives = 130/302 (43%), Gaps = 56/302 (18%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETH-EIVA--LKRVRLDDDDEGVPSSAL-REICLLKELK 59 Y+ E++G G + V K + + T E A +K+ + GV + RE+ +L+++ Sbjct: 14 YDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVL 73 Query: 60 HKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 H N++ LHDV + + L+ E F + L E SF+ Q+L G+ + H+ Sbjct: 74 HHNVITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHT 133 Query: 120 RNVLHRDLKPQN-LLINRN---GELKLADFGLARA----------FGIPVRCYSAEVVTL 165 + + H DLKP+N +L+++N +KL DFGLA FG P + E+V Sbjct: 134 KKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTP-EFVAPEIVN- 191 Query: 166 WYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEE 225 Y P DMWS G I L + P LG +E Sbjct: 192 -YEP---------LGLEADMWSIGVITYILLSGASP----------------FLGDTKQE 225 Query: 226 QWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPY 285 ++T + + T+ L +D ++ LL +R++ +EAL+HP+ Sbjct: 226 TLANITAVSYDFDEEFFSQTSEL----------AKDFIRKLLVKETRKRLTIQEALRHPW 275 Query: 286 FS 287 + Sbjct: 276 IT 277 >2XYN-A nrPDB Length = 292 Score = 85.9 bits (211), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 60/216 (27%), Positives = 107/216 (49%), Gaps = 10/216 (4%) Query: 9 KIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHD 68 K+G G YG V+ ++ VA+K ++ +D L+E ++KE+KH N+V+L Sbjct: 39 KLGGGQYGEVYVGVWKKYSLTVAVKTLK---EDTMEVEEFLKEAAVMKEIKHPNLVQLLG 95 Query: 69 VLHSDKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFL-FQLLKGLGFCHSRNVLHRD 126 V + +V E+ +L Y CN + +V ++ Q+ + + +N +HRD Sbjct: 96 VCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRD 155 Query: 127 LKPQNLLINRNGELKLADFGLARAF-GIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDM 185 L +N L+ N +K+ADFGL+R G ++ + + P+ L +S D+ Sbjct: 156 LAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESL-AYNTFSIKSDV 214 Query: 186 WSAGCIFAELANAGRPLFPGND---VDDQLKRIFRL 218 W+ G + E+A G +PG D V D L++ +R+ Sbjct: 215 WAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRM 250 >1ZWS-A nrPDB Length = 288 Score = 85.9 bits (211), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 77/302 (25%), Positives = 130/302 (43%), Gaps = 56/302 (18%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETH-EIVA--LKRVRLDDDDEGVPSSAL-REICLLKELK 59 Y+ E++G G + V K + + T E A +K+ + GV + RE+ +L+++ Sbjct: 14 YDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVL 73 Query: 60 HKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 H N++ LHDV + + L+ E F + L E SF+ Q+L G+ + H+ Sbjct: 74 HHNVITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHT 133 Query: 120 RNVLHRDLKPQN-LLINRN---GELKLADFGLARA----------FGIPVRCYSAEVVTL 165 + + H DLKP+N +L+++N +KL DFGLA FG P + E+V Sbjct: 134 KKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTP-EFVAPEIVN- 191 Query: 166 WYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEE 225 Y P DMWS G I L + P LG +E Sbjct: 192 -YEP---------LGLEADMWSIGVITYILLSGASP----------------FLGDTKQE 225 Query: 226 QWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPY 285 ++T + + T+ L +D ++ LL +R++ +EAL+HP+ Sbjct: 226 TLANITSVSYDFDEEFFSHTSEL----------AKDFIRKLLVKETRKRLTIQEALRHPW 275 Query: 286 FS 287 + Sbjct: 276 IT 277 >6F3F-A nrPDB Length = 455 Score = 85.5 bits (210), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 65/222 (29%), Positives = 114/222 (51%), Gaps = 24/222 (10%) Query: 9 KIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHD 68 K+G+G +G V+ T VA+K ++ P + L+E ++K+L+H+ +V+L+ Sbjct: 194 KLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMS---PEAFLQEAQVMKKLRHEKLVQLYA 249 Query: 69 VLHSDKKLTLVFEFCDQDLKKYFDSCNGDLD-----PEIVKSFLFQLLKGLGFCHSRNVL 123 V+ S++ + +V E+ ++ D G+ P++V Q+ G+ + N + Sbjct: 250 VV-SEEPIYIVTEYMNKG--SLLDFLKGETGKYLRLPQLV-DMSAQIASGMAYVERMNYV 305 Query: 124 HRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYS----AEVVTLWYRPPDVLFGAKLY 179 HRDL+ N+L+ N K+ADFGLAR I Y+ A+ W P L+G + Sbjct: 306 HRDLRAANILVGENLVCKVADFGLARL--IEDNEYTARQGAKFPIKWTAPEAALYGR--F 361 Query: 180 STSIDMWSAGCIFAELANAGRPLFPG---NDVDDQLKRIFRL 218 + D+WS G + EL GR +PG +V DQ++R +R+ Sbjct: 362 TIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRM 403 >2PL0-A nrPDB Length = 289 Score = 85.5 bits (210), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 62/222 (27%), Positives = 113/222 (50%), Gaps = 18/222 (8%) Query: 7 LEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRL 66 +E++G G +G V+ H VA+K ++ P + L E L+K+L+H+ +VRL Sbjct: 28 VERLGAGQFGEVWMGYYN-GHTKVAVKSLK---QGSMSPDAFLAEANLMKQLQHQRLVRL 83 Query: 67 HDVLHSDKKLTLVFEFCDQ-DLKKYFDSCNG-DLDPEIVKSFLFQLLKGLGFCHSRNVLH 124 + V+ + + + ++ E+ + L + + +G L + Q+ +G+ F RN +H Sbjct: 84 YAVV-TQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIH 142 Query: 125 RDLKPQNLLINRNGELKLADFGLARAFGIPVRCYS----AEVVTLWYRPPDVLFGAKLYS 180 RDL+ N+L++ K+ADFGLAR I Y+ A+ W P + +G ++ Sbjct: 143 RDLRAANILVSDTLSCKIADFGLARL--IEDNEYTAREGAKFPIKWTAPEAINYGT--FT 198 Query: 181 TSIDMWSAGCIFAELANAGRPLFPGN---DVDDQLKRIFRLL 219 D+WS G + E+ GR +PG +V L+R +R++ Sbjct: 199 IKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMV 240 >2H8H-A nrPDB Length = 535 Score = 85.5 bits (210), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 65/222 (29%), Positives = 113/222 (50%), Gaps = 24/222 (10%) Query: 9 KIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHD 68 K+G+G +G V+ T VA+K ++ P + L+E ++K+L+H+ +V+L+ Sbjct: 274 KLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMS---PEAFLQEAQVMKKLRHEKLVQLYA 329 Query: 69 VLHSDKKLTLVFEFCDQDLKKYFDSCNGDLD-----PEIVKSFLFQLLKGLGFCHSRNVL 123 V+ S++ + +V E+ + D G+ P++V Q+ G+ + N + Sbjct: 330 VV-SEEPIYIVTEYMSKG--SLLDFLKGETGKYLRLPQLV-DMAAQIASGMAYVERMNYV 385 Query: 124 HRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYS----AEVVTLWYRPPDVLFGAKLY 179 HRDL+ N+L+ N K+ADFGLAR I Y+ A+ W P L+G + Sbjct: 386 HRDLRAANILVGENLVCKVADFGLARL--IEDNEYTARQGAKFPIKWTAPEAALYGR--F 441 Query: 180 STSIDMWSAGCIFAELANAGRPLFPG---NDVDDQLKRIFRL 218 + D+WS G + EL GR +PG +V DQ++R +R+ Sbjct: 442 TIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRM 483 >5HVK-A nrPDB Length = 315 Score = 85.1 bits (209), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 54/203 (26%), Positives = 98/203 (48%), Gaps = 18/203 (8%) Query: 8 EKIGEGTYGTVFKAKNRETHEIVALKR-VRLDDDDEGVPSSALREICLLKELKHKNIVRL 66 E +G+G +G K +RET E++ +K +R D++ + + L+E+ +++ L+H N+++ Sbjct: 20 EVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQ---RTFLKEVKVMRCLEHPNVLKF 76 Query: 67 HDVLHSDKKLTLVFEFCDQD-LKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHR 125 VL+ DK+L + E+ L+ S + SF + G+ + HS N++HR Sbjct: 77 IGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHR 136 Query: 126 DLKPQNLLINRNGELKLADFGLA-------------RAFGIPVRCYSAEVVTLWYRPPDV 172 +L N L+ N + +ADFGLA R+ P R VV Y Sbjct: 137 NLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPE 196 Query: 173 LFGAKLYSTSIDMWSAGCIFAEL 195 + + Y +D++S G + E+ Sbjct: 197 MINGRSYDEKVDVFSFGIVLCEI 219 >2A1A-B nrPDB Length = 284 Score = 85.1 bits (209), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 64/213 (30%), Positives = 108/213 (50%), Gaps = 32/213 (15%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 ++++E IG G +G VFKAK+R + +KRV+ +++ A RE+ L +L H NI Sbjct: 13 FKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNE------KAEREVKALAKLDHVNI 66 Query: 64 VRL--------HDVLHSDKK--------LTLVFEFCDQD-LKKYFDSCNGD-LDPEIVKS 105 V +D S K L + EFCD+ L+++ + G+ LD + Sbjct: 67 VHYNGCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALE 126 Query: 106 FLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAF---GIPVRCYSAEV 162 Q+ KG+ + HS+ +++RDLKP N+ + ++K+ DFGL + G R Sbjct: 127 LFEQITKGVDYIHSKKLINRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKG--- 183 Query: 163 VTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAEL 195 TL Y P+ + ++ Y +D+++ G I AEL Sbjct: 184 -TLRYMSPEQI-SSQDYGKEVDLYALGLILAEL 214 >4CFF-A nrPDB Length = 571 Score = 85.1 bits (209), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 70/291 (24%), Positives = 129/291 (44%), Gaps = 44/291 (15%) Query: 8 EKIGEGTYGTVFKAKNRETHEIVALK---RVRLDDDDEGVPSSALREICLLKELKHKNIV 64 + +G GT+G V +++ T VA+K R ++ D V REI LK +H +I+ Sbjct: 39 DTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLD--VVGKIKREIQNLKLFRHPHII 96 Query: 65 RLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLH 124 +L+ V+ + +V E+ + +G ++ + Q+L + +CH V+H Sbjct: 97 KLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVH 156 Query: 125 RDLKPQNLLINRNGELKLADFGLARAFG----IPVRCYSAEVVTLWYRPPDVLFGAKLYS 180 RDLKP+N+L++ + K+ADFGL+ + C S Y P+V+ G Sbjct: 157 RDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPN-----YAAPEVISGRLYAG 211 Query: 181 TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYP 240 +D+WS G I L P D+ + +F+ + + +P+Y Sbjct: 212 PEVDIWSCGVILYALLCGTLPF-----DDEHVPTLFKKIRG-------GVFYIPEY---- 255 Query: 241 MYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCP 291 LN + LL ++L+ +P++R + ++ +H +F P Sbjct: 256 --------------LNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLP 292 >5SYS-A nrPDB Length = 286 Score = 85.1 bits (209), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 64/222 (28%), Positives = 113/222 (50%), Gaps = 24/222 (10%) Query: 9 KIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHD 68 K+G+G +G + T VA+K ++ P + L+E ++K+L+H+ +V+L+ Sbjct: 25 KLGQGCFGECWMGTWNGTTR-VAIKTLKPGTMS---PEAFLQEAQVMKKLRHEKLVQLYA 80 Query: 69 VLHSDKKLTLVFEFCDQDLKKYFDSCNGDLD-----PEIVKSFLFQLLKGLGFCHSRNVL 123 V+ S++ + +V E+ + D G++ P++V Q+ G+ + N + Sbjct: 81 VV-SEEPIYIVTEYMSKG--SLLDFLKGEMGKYLRLPQLV-DMAAQIASGMAYVERMNYV 136 Query: 124 HRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYS----AEVVTLWYRPPDVLFGAKLY 179 HRDL+ N+L+ N K+ADFGLAR I Y+ A+ W P L+G + Sbjct: 137 HRDLRAANILVGENLVCKVADFGLARL--IEDNEYTARQGAKFPIKWTAPEAALYGR--F 192 Query: 180 STSIDMWSAGCIFAELANAGRPLFPG---NDVDDQLKRIFRL 218 + D+WS G + EL GR +PG +V DQ++R +R+ Sbjct: 193 TIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRM 234 >4RA4-A nrPDB Length = 355 Score = 85.1 bits (209), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 61/214 (28%), Positives = 107/214 (50%), Gaps = 16/214 (7%) Query: 10 IGEGTYGTVFKAKNRETHEIVALKRVRLD----DDDEGVPSSALREICLLKELKHKNIVR 65 +G+G++G V A + T E+ A+K ++ D DDD R + LL K + + Sbjct: 28 LGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLD--KPPFLTQ 85 Query: 66 LHDVLHSDKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLH 124 LH + +L V E+ + DL + +P+ V + ++ GL F H R +++ Sbjct: 86 LHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAV-FYAAEISIGLFFLHKRGIIY 144 Query: 125 RDLKPQNLLINRNGELKLADFGLARAF---GIPVRCYSAEVVTLWYRPPDVLFGAKLYST 181 RDLK N++++ G +K+ADFG+ + G+ R + T Y P+++ + Y Sbjct: 145 RDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCG---TPDYIAPEII-AYQPYGK 200 Query: 182 SIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRI 215 S+D W+ G + E+ AG+P F G D D+ + I Sbjct: 201 SVDWWAYGVLLYEML-AGQPPFDGEDEDELFQSI 233 >2HK5-A nrPDB Length = 270 Score = 84.7 bits (208), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 68/230 (29%), Positives = 113/230 (49%), Gaps = 16/230 (6%) Query: 6 KLEK-IGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIV 64 KLEK +G G +G V+ A H VA+K ++ + L E ++K L+H +V Sbjct: 18 KLEKKLGAGQFGEVWMA-TYNKHTKVAVKTMKPGSMS---VEAFLAEANVMKTLQHDKLV 73 Query: 65 RLHDVLHSDKKLTLVFEFCDQ-DLKKYFDSCNGDLDP-EIVKSFLFQLLKGLGFCHSRNV 122 +LH V+ + + + ++ EF + L + S G P + F Q+ +G+ F RN Sbjct: 74 KLHAVV-TKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNY 132 Query: 123 LHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYS----AEVVTLWYRPPDVLFGAKL 178 +HRDL+ N+L++ + K+ADFGLAR I Y+ A+ W P + FG+ Sbjct: 133 IHRDLRAANILVSASLVCKIADFGLARV--IEDNEYTAREGAKFPIKWTAPEAINFGS-- 188 Query: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWP 228 ++ D+WS G + E+ GR +PG + ++ + R P E P Sbjct: 189 FTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCP 238 >2FO0-A nrPDB Length = 495 Score = 84.7 bits (208), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 58/214 (27%), Positives = 107/214 (50%), Gaps = 11/214 (5%) Query: 9 KIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHD 68 K+G G YG V++ ++ VA+K ++ D + L+E ++KE+KH N+V+L Sbjct: 224 KLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTME---VEEFLKEAAVMKEIKHPNLVQLLG 280 Query: 69 VLHSDKKLTLVFEFCD-QDLKKYFDSCN-GDLDPEIVKSFLFQLLKGLGFCHSRNVLHRD 126 V + ++ EF +L Y CN +++ ++ Q+ + + +N +HR+ Sbjct: 281 VCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRN 340 Query: 127 LKPQNLLINRNGELKLADFGLARAF-GIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDM 185 L +N L+ N +K+ADFGL+R G ++ + + P+ L K +S D+ Sbjct: 341 LAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNK-FSIKSDV 399 Query: 186 WSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLL 219 W+ G + E+A G +PG D L +++ LL Sbjct: 400 WAFGVLLWEIATYGMSPYPGID----LSQVYELL 429 >5EZV-A nrPDB Length = 560 Score = 84.7 bits (208), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 70/291 (24%), Positives = 129/291 (44%), Gaps = 44/291 (15%) Query: 8 EKIGEGTYGTVFKAKNRETHEIVALK---RVRLDDDDEGVPSSALREICLLKELKHKNIV 64 + +G GT+G V +++ T VA+K R ++ D V REI LK +H +I+ Sbjct: 34 DTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLD--VVGKIKREIQNLKLFRHPHII 91 Query: 65 RLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLH 124 +L+ V+ + +V E+ + +G ++ + Q+L + +CH V+H Sbjct: 92 KLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVH 151 Query: 125 RDLKPQNLLINRNGELKLADFGLARAFG----IPVRCYSAEVVTLWYRPPDVLFGAKLYS 180 RDLKP+N+L++ + K+ADFGL+ + C S Y P+V+ G Sbjct: 152 RDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPN-----YAAPEVISGRLYAG 206 Query: 181 TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYP 240 +D+WS G I L P D+ + +F+ + + +P+Y Sbjct: 207 PEVDIWSCGVILYALLCGTLPF-----DDEHVPTLFKKIRG-------GVFYIPEY---- 250 Query: 241 MYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCP 291 LN + LL ++L+ +P++R + ++ +H +F P Sbjct: 251 --------------LNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLP 287 >3FME-A nrPDB Length = 290 Score = 84.7 bits (208), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 75/295 (25%), Positives = 126/295 (42%), Gaps = 45/295 (15%) Query: 5 EKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI- 63 E + ++G G YG V K ++ + +I+A+KR+R V S + + + ++ + + Sbjct: 10 EPIMELGRGAYGVVEKMRHVPSGQIMAVKRIR-----ATVNSQEQKRLLMDLDISMRTVD 64 Query: 64 ----VRLHDVLHSDKKLTLVFEFCDQDLKKYFDSC--NGDLDPE-IVKSFLFQLLKGLGF 116 V + L + + + E D L K++ G PE I+ ++K L Sbjct: 65 CPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEH 124 Query: 117 CHSR-NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVL-- 173 HS+ +V+HRD+KP N+LIN G++K+ DFG++ + + + Y P+ + Sbjct: 125 LHSKLSVIHRDVKPSNVLINALGQVKMCDFGIS-GYLVDDVAKDIDAGCKPYMAPERINP 183 Query: 174 -FGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTK 232 K YS D+WS G ELA P QLK++ Sbjct: 184 ELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVE--------------- 228 Query: 233 LPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFS 287 +P P PA K +A D LK N +R + E +QHP+F+ Sbjct: 229 ----EPSPQLPAD--------KFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFT 271 >2YAB-A nrPDB Length = 361 Score = 84.3 bits (207), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 78/302 (25%), Positives = 130/302 (43%), Gaps = 56/302 (18%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETH-EIVA--LKRVRLDDDDEGVPSSAL-REICLLKELK 59 Y+ E++G G + V K + + T E A +K+ + GV + RE+ +L+++ Sbjct: 14 YDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIEREVSILRQVL 73 Query: 60 HKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 H NI+ LHDV + + L+ E F + L E SF+ Q+L G+ + H+ Sbjct: 74 HPNIITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHT 133 Query: 120 RNVLHRDLKPQN-LLINRN---GELKLADFGLARA----------FGIPVRCYSAEVVTL 165 + + H DLKP+N +L+++N +KL DFGLA FG P + E+V Sbjct: 134 KKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTP-EFVAPEIVN- 191 Query: 166 WYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEE 225 Y P DMWS G I L + P LG +E Sbjct: 192 -YEP---------LGLEADMWSIGVITYILLSGASP----------------FLGDTKQE 225 Query: 226 QWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPY 285 ++T + + T+ L +D ++ LL +R++ +EAL+HP+ Sbjct: 226 TLANITAVSYDFDEEFFSQTSEL----------AKDFIRKLLVKETRKRLTIQEALRHPW 275 Query: 286 FS 287 + Sbjct: 276 IT 277 >3ORZ-A nrPDB Length = 316 Score = 84.3 bits (207), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 76/282 (26%), Positives = 124/282 (43%), Gaps = 32/282 (11%) Query: 10 IGEGTYGTVFKAKNRETHEIVALKRV--RLDDDDEGVPSSALREICLLKELKHKNIVRLH 67 +GEG++ TV A+ T A+K + R + VP RE ++ L H V+L+ Sbjct: 45 LGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPY-VTRERDVMSRLDHPFFVKLY 103 Query: 68 DVLHSDKKLTLVFEFC-DQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRD 126 D+KL + + +L KY G D + + +++ L + H + ++HRD Sbjct: 104 FCFQDDEKLYFGLSYAKNGELLKYIRKI-GSFDETCTRFYTAEIVSALEYLHGKGIIHRD 162 Query: 127 LKPQNLLINRNGELKLADFGLARAFGIPVRCYSAE--VVTLWYRPPDVLFGAKLYSTSID 184 LKP+N+L+N + +++ DFG A+ + A V T Y P++L K S D Sbjct: 163 LKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELL-TEKSACKSSD 221 Query: 185 MWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPA 244 +W+ GCI +L P GN+ IF+ + KL P +P Sbjct: 222 LWALGCIIYQLVAGLPPFRAGNEY-----LIFQ-----------KIIKLEYDFPEKFFPK 265 Query: 245 TTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286 LV + L+AT R L C ++ +A HP+F Sbjct: 266 ARDLVEKLLVLDATKR------LGCEEMEGYGPLKA--HPFF 299 >6CMJ-A nrPDB Length = 321 Score = 84.3 bits (207), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 79/303 (26%), Positives = 133/303 (43%), Gaps = 48/303 (15%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDD---------DDEGVPSSALRE 51 + +Y ++IG+G+YG V A N + A+K + G +E Sbjct: 33 LDQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGGCIQPRGPIEQVYQE 92 Query: 52 ICLLKELKHKNIVRLHDVLH--SDKKLTLVFEFCDQDLKKYFDSCNGDLDP--EIVKSFL 107 I +LK+L H N+V+L +VL ++ L +VFE +Q + L P E F Sbjct: 93 IAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPT----LKPLSEDQARFY 148 Query: 108 FQ-LLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLW 166 FQ L+KG+ + H + ++HRD+KP NLL+ +G +K+ADFG++ F S V T Sbjct: 149 FQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPA 208 Query: 167 YRPPDVLFGA-KLYS-TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTE 224 + P+ L K++S ++D+W+ G P +D+++ + + + Sbjct: 209 FMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPF-----MDERIMCLHSKIKSQAL 263 Query: 225 EQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHP 284 E PD P + +DL+ +L NP RI E HP Sbjct: 264 E-------FPDQ----------------PDIAEDLKDLITRMLDKNPESRIVVPEIKLHP 300 Query: 285 YFS 287 + + Sbjct: 301 WVT 303 >3UIU-A nrPDB Length = 306 Score = 84.3 bits (207), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 65/226 (28%), Positives = 109/226 (48%), Gaps = 45/226 (19%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 ++++E IG G +G VFKAK+R + ++RV+ +++ A RE+ L +L H NI Sbjct: 14 FKEIELIGSGGFGQVFKAKHRIDGKTYVIRRVKYNNE------KAEREVKALAKLDHVNI 67 Query: 64 VRLH--------------DVLHSD---------------KKLTLVFEFCDQ-DLKKYFDS 93 V + D L S K L + EFCD+ L+++ + Sbjct: 68 VHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEK 127 Query: 94 CNGD-LDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAF- 151 G+ LD + Q+ KG+ + HS+ ++HRDLKP N+ + ++K+ DFGL + Sbjct: 128 RRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLK 187 Query: 152 --GIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAEL 195 G R TL Y P+ + ++ Y +D+++ G I AEL Sbjct: 188 NDGKRTRSKG----TLRYMSPEQI-SSQDYGKEVDLYALGLILAEL 228 >4I6B-A nrPDB Length = 308 Score = 84.0 bits (206), Expect = 8e-17, Method: Compositional matrix adjust. Identities = 69/296 (23%), Positives = 128/296 (43%), Gaps = 41/296 (13%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALK-----RVRLDDDDEGVPSSALREICLLK 56 ++Y + + +G+G + ++ + +++ A K RV E + +EI L + Sbjct: 28 KRYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKID----KEIELHR 83 Query: 57 ELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGF 116 L HK++V+ + + + ++ E+C + + L V+ +L Q++ GL + Sbjct: 84 ILHHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKY 143 Query: 117 CHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGA 176 H + +LHRDLK N IN + ELK+ DFGLA T Y P+VL Sbjct: 144 LHEQEILHRDLKLGNFFINESMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVL-NK 202 Query: 177 KLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDY 236 + + D+W+ GC+ + GRP F ++ + + I Sbjct: 203 QGHGAESDIWALGCVMYTML-LGRPPFETTNLKETYRSIRE------------------- 242 Query: 237 KPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD-FCP 291 Y +SL+ A + L+ ++L NP R S ++ ++H +F+ F P Sbjct: 243 ---ARYTMPSSLL-------APAKHLIASMLSKNPEDRPSLDDIIRHDFFTQGFTP 288 >3LM0-A nrPDB Length = 327 Score = 83.6 bits (205), Expect = 9e-17, Method: Compositional matrix adjust. Identities = 73/291 (25%), Positives = 135/291 (46%), Gaps = 40/291 (13%) Query: 8 EKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH-KNIVRL 66 +++G G + V + ++ T + A K ++ + + L EI +L+ K ++ L Sbjct: 35 KELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELAKSCPRVINL 94 Query: 67 HDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEI----VKSFLFQLLKGLGFCHSRNV 122 H+V + ++ L+ E+ + F C +L + V + Q+L+G+ + H N+ Sbjct: 95 HEVYENTSEIILILEYAAGG--EIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQNNI 152 Query: 123 LHRDLKPQNLLINRN---GELKLADFGLARAFGIPVRCYSAEVV-TLWYRPPDVLFGAKL 178 +H DLKPQN+L++ G++K+ DFG++R G C E++ T Y P++L + Sbjct: 153 VHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHA--CELREIMGTPEYLAPEILNYDPI 210 Query: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKP 238 +T+ DMW+ G I L P F G D + I ++ +EE + S+++L Sbjct: 211 -TTATDMWNIGIIAYMLLTHTSP-FVGEDNQETYLNISQVNVDYSEETFSSVSQL----- 263 Query: 239 YPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDF 289 D +Q+LL NP +R +AE L H + + Sbjct: 264 --------------------ATDFIQSLLVKNPEKRPTAEICLSHSWLQQW 294 >2YZA-A nrPDB Length = 276 Score = 83.6 bits (205), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 72/291 (24%), Positives = 127/291 (43%), Gaps = 44/291 (15%) Query: 8 EKIGEGTYGTVFKAKNRETHEIVALK---RVRLDDDDEGVPSSALREICLLKELKHKNIV 64 + +G GT+G V +++ T VA+K R ++ D V REI LK +H +I+ Sbjct: 17 DTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLD--VVGKIKREIQNLKLFRHPHII 74 Query: 65 RLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLH 124 +L+ V+ + +V E+ + +G ++ + Q+L + +CH V+H Sbjct: 75 KLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVH 134 Query: 125 RDLKPQNLLINRNGELKLADFGLARAFG----IPVRCYSAEVVTLWYRPPDVLFGAKLYS 180 RDLKP+N+L++ + K+ADFGL+ + C S Y P+V+ G Sbjct: 135 RDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRDSCGSPN-----YAAPEVISGRLYAG 189 Query: 181 TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYP 240 +D+WS G I L P F V K+I + +P+Y Sbjct: 190 PEVDIWSCGVILYALLCGTLP-FDDEHVPTLFKKI-----------RGGVFYIPEY---- 233 Query: 241 MYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCP 291 LN + LL ++L+ +P++R + ++ +H +F P Sbjct: 234 --------------LNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLP 270 >4YZB-A nrPDB Length = 491 Score = 83.2 bits (204), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 81/302 (26%), Positives = 139/302 (46%), Gaps = 61/302 (20%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHE-----IVALKRVRLDDDDEGVPSSALREICLLKE 57 +Y+ +G+G++G V K++ T + +++ ++V+ D L+E+ LLK+ Sbjct: 31 RYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTD----KELLLKEVELLKK 86 Query: 58 LKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLF--------- 108 L H NI++L++ LV E G+L EI+ F Sbjct: 87 LDHPNIMKLYEFFEDKGYFYLVTEVY----------TGGELFDEIISRKRFSEVDAARII 136 Query: 109 -QLLKGLGFCHSRNVLHRDLKPQNLLIN---RNGELKLADFGLARAFGIPVRCYSAEVVT 164 Q+L G+ + H ++HRDLKP+NLL+ ++ +++ DFGL+ F + ++ T Sbjct: 137 RQVLSGITYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFE-STKKMKDKIGT 195 Query: 165 LWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTE 224 +Y P+VL G Y D+WS G I L +G P F G + D LK++ Sbjct: 196 AYYIAPEVLHGT--YDEKCDVWSTGVILYILL-SGCPPFNGANEFDILKKV--------- 243 Query: 225 EQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHP 284 E+ LP +K K++ +DL++ +L P RISA +AL+H Sbjct: 244 EKGKFTFDLPQWK----------------KVSEPAKDLIRKMLAYVPTMRISARDALEHE 287 Query: 285 YF 286 + Sbjct: 288 WL 289 >3CJF-A nrPDB Length = 309 Score = 82.8 bits (203), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 80/287 (27%), Positives = 124/287 (43%), Gaps = 39/287 (13%) Query: 10 IGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELK-------HKN 62 +G G +G V +A + + V + EG S R L+ ELK H N Sbjct: 35 LGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHR--ALMSELKILIHIGHHLN 92 Query: 63 IVRLHDVLHS-DKKLTLVFEFCD-QDLKKYFDSCNGDLDP--EIVKSFL---------FQ 109 +V L L ++ EFC +L Y S + P ++ K FL FQ Sbjct: 93 VVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKDLYKDFLTLEHLICYSFQ 152 Query: 110 LLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLAR-AFGIP--VRCYSAEVVTLW 166 + KG+ F SR +HRDL +N+L++ +K+ DFGLAR + P VR A + W Sbjct: 153 VAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKW 212 Query: 167 YRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQ 226 P + ++Y+ D+WS G + E+ + G +PG +D++ R + GT Sbjct: 213 MAPETIF--DRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLK-EGT----- 264 Query: 227 WPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQ---NLLKCN 270 + PDY MY + P T +L++ NLL+ N Sbjct: 265 ---RMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQAN 308 >5UNP-A nrPDB Length = 369 Score = 82.8 bits (203), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 87/329 (26%), Positives = 141/329 (42%), Gaps = 52/329 (15%) Query: 2 QKYEKLEKIGEGTYGTVFK-AKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 ++YE + +GEGT+G V + +R VALK ++ + E +A EI +L+++ Sbjct: 34 ERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIK---NVEKYKEAARLEINVLEKINE 90 Query: 61 KN------IVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDP-EIVKSFLFQLLKG 113 K+ V++ D + + FE + N P V+ FQL + Sbjct: 91 KDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQA 150 Query: 114 LGFCHSRNVLHRDLKPQNLL-INRNGEL------------------KLADFGLARAFGIP 154 + F H + H DLKP+N+L +N + EL ++ DFG A Sbjct: 151 VKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSA---TFD 207 Query: 155 VRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKR 214 +S V T YR P+V+ +S D+WS GCI E G LF +D + L Sbjct: 208 HEHHSTIVSTRHYRAPEVILELG-WSQPCDVWSIGCIIFEYY-VGFTLFQTHDNREHLAM 265 Query: 215 IFRLLG-------TPTEEQ---------WPSMTKLPDYKPYPMYPATTSLVNVVPKLNAT 258 + R+LG T +Q W T Y P L + + + Sbjct: 266 MERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQL 325 Query: 259 GRDLLQNLLKCNPVQRISAEEALQHPYFS 287 DL++++L+ P +R++ EALQHP+F+ Sbjct: 326 F-DLIESMLEYEPAKRLTLGEALQHPFFA 353 >3A8W-A nrPDB Length = 345 Score = 82.8 bits (203), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 56/205 (27%), Positives = 97/205 (47%), Gaps = 4/205 (1%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVR--LDDDDEGVPSSALREICLLKEL 58 +Q ++ L IG G+Y V + ++T I A+K V+ L +DDE + + + Sbjct: 8 LQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQAS 67 Query: 59 KHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCH 118 H +V LH ++ +L V E+ + + L E + + ++ L + H Sbjct: 68 NHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLH 127 Query: 119 SRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL 178 R +++RDLK N+L++ G +KL D+G+ + P S T Y P++L G Sbjct: 128 ERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGED- 186 Query: 179 YSTSIDMWSAGCIFAELANAGRPLF 203 Y S+D W+ G + E+ AGR F Sbjct: 187 YGFSVDWWALGVLMFEMM-AGRSPF 210 >5DYK-A nrPDB Length = 853 Score = 82.8 bits (203), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 87/299 (29%), Positives = 136/299 (45%), Gaps = 45/299 (15%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 M + E IG GT+GTV ++ T ALK V + + I L +E+ Sbjct: 538 MDELETERIIGRGTFGTVKLVHHKPTKIRYALKCV---SKRSIINLNQQNNIKLEREITA 594 Query: 61 KN----IVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCN--GDLDPEIVKSFLFQLLKGL 114 +N I+RL K + E + +D+ G L + +L ++ + Sbjct: 595 ENDHPFIIRLVRTFKDSKYFYFLTELVTGG--ELYDAIRKLGLLSKSQAQFYLGSIILAI 652 Query: 115 GFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLF 174 + H RN+++RDLKP+N+L+++ G +KL DFG A+ + R Y+ V T Y P+V+ Sbjct: 653 EYLHERNIVYRDLKPENILLDKQGYVKLIDFGCAKK--VQGRAYTL-VGTPHYMAPEVIL 709 Query: 175 GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFR--LLGTPTEEQWPSMTK 232 G K Y ++D+W+ G E PL GND +DQL+ IFR L G T Sbjct: 710 G-KGYGCTVDIWALGICLYEFICG--PLPFGNDEEDQLE-IFRDILTGQLT--------- 756 Query: 233 LPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKC--NPVQRISAEEALQHPYFSDF 289 +P Y T +N++ +L L Q + C N + I HP+FS+F Sbjct: 757 ------FPDYVTDTDSINLMKRLLCR---LPQGRIGCSINGFKDIK-----DHPFFSNF 801 >4E93-A nrPDB Length = 377 Score = 82.0 bits (201), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 61/217 (28%), Positives = 101/217 (46%), Gaps = 17/217 (7%) Query: 8 EKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVP----SSALREICLLKELKHKNI 63 E+IG G +G VF + R + +VA+K R E +P + L+E +LK+ H NI Sbjct: 120 EQIGRGNFGEVFSGRLRADNTLVAVKSCR-----ETLPPDLKAKFLQEARILKQYSHPNI 174 Query: 64 VRLHDVLHSDKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNV 122 VRL V + + +V E D + + L + + + G+ + S+ Sbjct: 175 VRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCC 234 Query: 123 LHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSA---EVVTLWYRPPDVLFGAKLY 179 +HRDL +N L+ LK++DFG++R V S +V W P + +G Y Sbjct: 235 IHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGR--Y 292 Query: 180 STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIF 216 S+ D+WS G + E + G +P ++ +Q R F Sbjct: 293 SSESDVWSFGILLWETFSLGASPYP--NLSNQQTREF 327 >5VD3-A nrPDB Length = 311 Score = 81.6 bits (200), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 57/198 (28%), Positives = 94/198 (47%), Gaps = 8/198 (4%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKEL-KH 60 Q +++L ++G G+YG VFK +++E + A+KR + L E+ +++ +H Sbjct: 57 QSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQH 116 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 VRL L L E C L+++ ++ L V +L L L HS+ Sbjct: 117 PCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQ 176 Query: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTL--WYRPPDVLFGAKL 178 ++H D+KP N+ + G KL DFGL G + EV Y P++L G+ Sbjct: 177 GLVHLDVKPANIFLGPRGRCKLGDFGLLVELGT---AGAGEVQEGDPRYMAPELLQGS-- 231 Query: 179 YSTSIDMWSAGCIFAELA 196 Y T+ D++S G E+A Sbjct: 232 YGTAADVFSLGLTILEVA 249 >3PPZ-A nrPDB Length = 309 Score = 81.6 bits (200), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 61/199 (30%), Positives = 98/199 (49%), Gaps = 8/199 (4%) Query: 8 EKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLH 67 EKIG G++GTV +A+ + VA+K + D + LRE+ ++K L+H NIV Sbjct: 43 EKIGAGSFGTVHRAEWHGSD--VAVKILMEQDFHAERVNEFLREVAIMKRLRHPNIVLFM 100 Query: 68 DVLHSDKKLTLVFEFCDQ-DLKKYFDSCNG--DLDPEIVKSFLFQLLKGLGFCHSRN--V 122 + L++V E+ + L + LD S + + KG+ + H+RN + Sbjct: 101 GAVTQPPNLSIVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAKGMNYLHNRNPPI 160 Query: 123 LHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTS 182 +HRDLK NLL+++ +K+ DFGL+R + T + P+VL S Sbjct: 161 VHRDLKSPNLLVDKKYTVKVCDFGLSRLKASTFLSSKSAAGTPEWMAPEVLRDEPSNEKS 220 Query: 183 IDMWSAGCIFAELANAGRP 201 D++S G I ELA +P Sbjct: 221 -DVYSFGVILWELATLQQP 238 >6CTH-A nrPDB Length = 309 Score = 81.6 bits (200), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 66/214 (30%), Positives = 107/214 (50%), Gaps = 34/214 (15%) Query: 9 KIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHD 68 K+GEG +G+V++ R++ +A+K+V +G+ A E+ ++ L+HKN+V+L Sbjct: 22 KLGEGGFGSVYRGFLRDSDTYIAVKKVS-RASKQGIKEYA-SEVKIISRLRHKNLVKLIG 79 Query: 69 VLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVK--SFL-----FQLLKGLG----FC 117 H +L LV+EF NG LD I K S L ++++K L + Sbjct: 80 WCHERGELMLVYEFM----------ANGSLDSHIFKGKSLLTWEVRYRIVKDLASALLYL 129 Query: 118 HSRN---VLHRDLKPQNLLINRNGELKLADFGLAR----AFGIPVRCYSAEVVTLWYRPP 170 H VLHRD+K N++++ + KL DFGLAR A G+ + T+ Y P Sbjct: 130 HEEGDHCVLHRDIKTSNIMLDSSFNAKLGDFGLARLVDHAKGLKKTLLAG---TVGYMAP 186 Query: 171 DVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFP 204 + L K S D++S G + E+A+ R + P Sbjct: 187 ECLSSGKASKES-DVYSFGVVALEIASGRRSIEP 219 >4F9B-A nrPDB Length = 361 Score = 81.6 bits (200), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 85/344 (24%), Positives = 133/344 (38%), Gaps = 73/344 (21%) Query: 8 EKIGEGTYGTVFKAKNRET---HEIVALKRVRLDDDDEGVPSS-----ALREICLLKELK 59 +KIGEGT+ +V+ A + E +ALK + +P+S A CL Sbjct: 27 DKIGEGTFSSVYLATAQLQVGPEEKIALKHL--------IPTSHPIRIAAELQCLTVAGG 78 Query: 60 HKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 N++ + + + + + + + + D N L + V+ ++ L K L H Sbjct: 79 QDNVMGVKYCFRKNDHVVIAMPYLEHE--SFLDILN-SLSFQEVREYMLNLFKALKRIHQ 135 Query: 120 RNVLHRDLKPQNLLINRN-GELKLADFGLARAF--------------GIPVRC------- 157 ++HRD+KP N L NR + L DFGLA+ RC Sbjct: 136 FGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNKCSI 195 Query: 158 -------YSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDD 210 + T +R P+VL +T+IDMWSAG IF L + P + +D Sbjct: 196 CLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDDLT 255 Query: 211 QLKRIFRLLGTPTEEQWPSM--------TKLPDYKPYPMYPATTSLVNVVPKLNATGRDL 262 L +I + G+ Q ++P + + + PKL + + Sbjct: 256 ALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSSTPKLTSDIQGH 315 Query: 263 LQNL-----------------LKCNPVQRISAEEALQHPYFSDF 289 NL L NP RI+AEEAL HP+F D Sbjct: 316 ATNLEGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFFKDM 359 >1NY3-A nrPDB Length = 400 Score = 81.3 bits (199), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 85/293 (29%), Positives = 127/293 (43%), Gaps = 53/293 (18%) Query: 10 IGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICL-LKELKHKNIVRLHD 68 +G G G V + N+ T E ALK + + P A RE+ L + + +IVR+ D Sbjct: 70 LGLGINGKVLQIFNKRTQEKFALKML------QDCPK-ARREVELHWRASQCPHIVRIVD 122 Query: 69 V---LHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLG----FCHSRN 121 V L++ +K L+ C D + F D + +++K +G + HS N Sbjct: 123 VYENLYAGRKCLLIVMEC-LDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSIN 181 Query: 122 VLHRDLKPQNLLINR---NGELKLADFGLARAF----GIPVRCYSAEVVTLWYRPPDVLF 174 + HRD+KP+NLL N LKL DFG A+ + CY T +Y P+VL Sbjct: 182 IAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCY-----TPYYVAPEVL- 235 Query: 175 GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLP 234 G + Y S DMWS G I L G P F N G + ++ Sbjct: 236 GPEKYDKSCDMWSLGVIMYILL-CGYPPFYSNH------------GLAISPGMKTRIRMG 282 Query: 235 DYK-PYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286 Y+ P P + + V + L++NLLK P QR++ E + HP+ Sbjct: 283 QYEFPNPEWSEVSEEVKM----------LIRNLLKTEPTQRMTITEFMNHPWI 325 >4NIF-A nrPDB Length = 333 Score = 81.3 bits (199), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 79/298 (26%), Positives = 133/298 (44%), Gaps = 61/298 (20%) Query: 8 EKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLH 67 E IG G+Y + ++ T+ A+K + D + PS + LL+ +H NI+ L Sbjct: 14 ETIGVGSYSECKRCVHKATNMEYAVKVI---DKSKRDPSEEIE--ILLRYGQHPNIITLK 68 Query: 68 DVLHSDKKLTLVFEFC------DQDLKKYFDSCNGDLDPEIVKSFLFQLL-KGLGFCHSR 120 DV K + LV E D+ L++ F S E SF+ + K + + HS+ Sbjct: 69 DVYDDGKHVYLVTELMRGGELLDKILRQKFFS-------EREASFVLHTIGKTVEYLHSQ 121 Query: 121 NVLHRDLKPQNLL-INRNGE---LKLADFGLARAFG-----IPVRCYSAEVVTLWYRPPD 171 V+HRDLKP N+L ++ +G L++ DFG A+ + CY+A V P+ Sbjct: 122 GVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVA-----PE 176 Query: 172 VLFGAKLYSTSIDMWSAGCIFAELANAGRPLF--PGNDVDDQLKRIFRLLGTPTEEQWPS 229 VL + Y D+WS G + + P P + ++ L RI T + W + Sbjct: 177 VL-KRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNT 235 Query: 230 MTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFS 287 +++ T +DL+ +L +P QR++A++ LQHP+ + Sbjct: 236 VSE-------------------------TAKDLVSKMLHVDPHQRLTAKQVLQHPWVT 268 >3DLS-A nrPDB Length = 335 Score = 80.9 bits (198), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 57/209 (27%), Positives = 102/209 (48%), Gaps = 10/209 (4%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVR----LDD---DDEGVPSSALREICL 54 QKY + +G G +G V+ A ++E ++ V +K ++ L+D +D + L EI + Sbjct: 24 QKYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTL-EIAI 82 Query: 55 LKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKY-FDSCNGDLDPEIVKSFLFQLLKG 113 L ++H NI+++ D+ + LV E L + F + LD + QL+ Sbjct: 83 LSRVEHANIIKVLDIFENQGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASYIFRQLVSA 142 Query: 114 LGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVL 173 +G+ ++++HRD+K +N++I + +KL DFG A A+ + + T+ Y P+VL Sbjct: 143 VGYLRLKDIIHRDIKDENIVIAEDFTIKLIDFGSA-AYLERGKLFYTFCGTIEYCAPEVL 201 Query: 174 FGAKLYSTSIDMWSAGCIFAELANAGRPL 202 G ++MWS G L P Sbjct: 202 MGNPYRGPELEMWSLGVTLYTLVFEENPF 230 >2OZA-A nrPDB Length = 356 Score = 80.9 bits (198), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 85/293 (29%), Positives = 127/293 (43%), Gaps = 53/293 (18%) Query: 10 IGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICL-LKELKHKNIVRLHD 68 +G G G V + N+ T E ALK + + P A RE+ L + + +IVR+ D Sbjct: 26 LGLGINGKVLQIFNKRTQEKFALKML------QDCPK-ARREVELHWRASQCPHIVRIVD 78 Query: 69 V---LHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLG----FCHSRN 121 V L++ +K L+ C D + F D + +++K +G + HS N Sbjct: 79 VYENLYAGRKCLLIVMEC-LDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSIN 137 Query: 122 VLHRDLKPQNLLINR---NGELKLADFGLARAF----GIPVRCYSAEVVTLWYRPPDVLF 174 + HRD+KP+NLL N LKL DFG A+ + CY T +Y P+VL Sbjct: 138 IAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCY-----TPYYVAPEVL- 191 Query: 175 GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLP 234 G + Y S DMWS G I L G P F N G + ++ Sbjct: 192 GPEKYDKSCDMWSLGVIMYILL-CGYPPFYSNH------------GLAISPGMKTRIRMG 238 Query: 235 DYK-PYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286 Y+ P P + + V + L++NLLK P QR++ E + HP+ Sbjct: 239 QYEFPNPEWSEVSEEVKM----------LIRNLLKTEPTQRMTITEFMNHPWI 281 >2YCR-A nrPDB Length = 323 Score = 80.5 bits (197), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 78/292 (26%), Positives = 130/292 (44%), Gaps = 42/292 (14%) Query: 10 IGEGTYGTVFKAKNRETHEIVALK-----RVRLDDDDEGVPS-SALREICLLKELKHKNI 63 +G G G V A R+T + VA+K + + E P+ + EI +LK+L H I Sbjct: 18 LGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCI 77 Query: 64 VRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGD--LDPEIVKSFLFQLLKGLGFCHSRN 121 +++ + ++ +V E + + FD G+ L K + +Q+L + + H Sbjct: 78 IKIKNFFDAED-YYIVLELMEGG--ELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENG 134 Query: 122 VLHRDLKPQNLLINRNGE---LKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVL--FGA 176 ++HRDLKP+N+L++ E +K+ DFG ++ G T Y P+VL G Sbjct: 135 IIHRDLKPENVLLSSQEEDCLIKITDFGHSKILG-ETSLMRTLCGTPTYLAPEVLVSVGT 193 Query: 177 KLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDY 236 Y+ ++D WS G I + +G P F + LK +Q S Sbjct: 194 AGYNRAVDCWSLGVILF-ICLSGYPPFSEHRTQVSLK-----------DQITS------- 234 Query: 237 KPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288 Y P V +++ DL++ LL +P R + EEAL+HP+ D Sbjct: 235 GKYNFIP------EVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQD 280 >1KOB-A nrPDB Length = 387 Score = 80.5 bits (197), Expect = 8e-16, Method: Compositional matrix adjust. Identities = 65/292 (22%), Positives = 124/292 (42%), Gaps = 45/292 (15%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVR----LDDDDEGVPSSALREICLLKELK 59 Y+ LE++G G +G V + + T + K + LD + EI ++ +L Sbjct: 53 YDILEELGSGAFGVVHRCVEKATGRVFVAKFINTPYPLDK------YTVKNEISIMNQLH 106 Query: 60 HKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGD---LDPEIVKSFLFQLLKGLGF 116 H ++ LHD ++ L+ EF + FD + + V +++ Q +GL Sbjct: 107 HPKLINLHDAFEDKYEMVLILEFLSGG--ELFDRIAAEDYKMSEAEVINYMRQACEGLKH 164 Query: 117 CHSRNVLHRDLKPQNLL--INRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLF 174 H +++H D+KP+N++ + +K+ DFGLA P T + P+++ Sbjct: 165 MHEHSIVHLDIKPENIMCETKKASSVKIIDFGLATKLN-PDEIVKVTTATAEFAAPEIV- 222 Query: 175 GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLP 234 + DMW+ G + L + P F G D + L+ + R E+ + S++ Sbjct: 223 DREPVGFYTDMWAIGVLGYVLLSGLSP-FAGEDDLETLQNVKRCDWEFDEDAFSSVS--- 278 Query: 235 DYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286 +D ++NLL+ P +R++ +AL+HP+ Sbjct: 279 ----------------------PEAKDFIKNLLQKEPRKRLTVHDALEHPWL 308 >3ORP-A nrPDB Length = 311 Score = 80.5 bits (197), Expect = 8e-16, Method: Compositional matrix adjust. Identities = 62/214 (28%), Positives = 99/214 (46%), Gaps = 14/214 (6%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALR---EICLLKELK 59 +YE E +G G V A++ H VA+K +R D + PS LR E L Sbjct: 13 RYELGEILGFGGMSEVHLARDLRDHRDVAVKVLRADLARD--PSFYLRFRREAQNAAALN 70 Query: 60 HKNIVRLHDVLHSDKKLT----LVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLG 115 H IV ++D ++ +V E+ D + G + P+ + + L Sbjct: 71 HPAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIVHTEGPMTPKRAIEVIADACQALN 130 Query: 116 FCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAF---GIPVRCYSAEVVTLWYRPPDV 172 F H ++HRD+KP N++I+ +K+ DFG+ARA G V +A + T Y P+ Sbjct: 131 FSHQNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGTAQYLSPEQ 190 Query: 173 LFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGN 206 G + + S D++S GC+ E+ G P F G+ Sbjct: 191 ARGDSVDARS-DVYSLGCVLYEVLT-GEPPFTGD 222 >6DBN-A nrPDB Length = 316 Score = 80.1 bits (196), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 56/202 (27%), Positives = 98/202 (48%), Gaps = 14/202 (6%) Query: 5 EKLEKIGEGTYGTV----FKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 +++ +GEG +G V + + T E VA+K ++ + + + +EI +L+ L H Sbjct: 38 KRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHI-ADLKKEIEILRNLYH 96 Query: 61 KNIVRLHDVLHSD--KKLTLVFEFC-DQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFC 117 +NIV+ + D + L+ EF LK+Y ++ + + Q+ KG+ + Sbjct: 97 ENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYL 156 Query: 118 HSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSA----EVVTLWYRPPDVL 173 SR +HRDL +N+L+ ++K+ DFGL +A Y+ + WY P+ L Sbjct: 157 GSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWY-APECL 215 Query: 174 FGAKLYSTSIDMWSAGCIFAEL 195 +K Y S D+WS G EL Sbjct: 216 MQSKFYIAS-DVWSFGVTLHEL 236 >3KA0-A nrPDB Length = 320 Score = 80.1 bits (196), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 85/293 (29%), Positives = 127/293 (43%), Gaps = 53/293 (18%) Query: 10 IGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICL-LKELKHKNIVRLHD 68 +G G G V + N+ T E ALK + + P A RE+ L + + +IVR+ D Sbjct: 24 LGLGINGKVLQIFNKRTQEKFALKML------QDCPK-ARREVELHWRASQCPHIVRIVD 76 Query: 69 V---LHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLG----FCHSRN 121 V L++ +K L+ C D + F D + +++K +G + HS N Sbjct: 77 VYENLYAGRKCLLIVMEC-LDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSIN 135 Query: 122 VLHRDLKPQNLLINR---NGELKLADFGLARAF----GIPVRCYSAEVVTLWYRPPDVLF 174 + HRD+KP+NLL N LKL DFG A+ + CY T +Y P+VL Sbjct: 136 IAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTEPCY-----TPYYVAPEVL- 189 Query: 175 GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLP 234 G + Y S DMWS G I L G P F N G + ++ Sbjct: 190 GPEKYDKSCDMWSLGVIMYILL-CGYPPFYSNH------------GLAISPGMKTRIRMG 236 Query: 235 DYK-PYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286 Y+ P P + + V + L++NLLK P QR++ E + HP+ Sbjct: 237 QYEFPNPEWSEVSEEVKM----------LIRNLLKTEPTQRMTITEFMNHPWI 279 >2PSQ-A nrPDB Length = 370 Score = 79.7 bits (195), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 64/236 (27%), Positives = 113/236 (47%), Gaps = 32/236 (13%) Query: 10 IGEGTYGTVFKA------KNRETHEIVALKRVRLDDDDEGVPSSALREICLLKEL-KHKN 62 +GEG +G V A K++ + ++ DD E S + E+ ++K + KHKN Sbjct: 89 LGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKN 148 Query: 63 IVRLHDVLHSDKKLTLVFEFCDQ-DLKKYFD---------SCNGDLDPEIVKSF------ 106 I+ L D L ++ E+ + +L++Y S + + PE +F Sbjct: 149 IINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSC 208 Query: 107 LFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFG---IPVRCYSAEVV 163 +QL +G+ + S+ +HRDL +N+L+ N +K+ADFGLAR + + + Sbjct: 209 TYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLP 268 Query: 164 TLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLL 219 W P+ LF ++Y+ D+WS G + E+ G +PG V++ +F+LL Sbjct: 269 VKWM-APEALFD-RVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEE----LFKLL 318 >5TQX-A nrPDB Length = 655 Score = 79.7 bits (195), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 64/212 (30%), Positives = 103/212 (48%), Gaps = 16/212 (7%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 +E E++G G +G V ++RE +A+K RL+ + EI ++K+L H N+ Sbjct: 10 WEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKN-RERWCHEIQIMKKLNHANV 68 Query: 64 VRLHDVLHSDKKLT-----LVFEFCDQ-DLKKYF---DSCNGDLDPEIVKSFLFQLLKGL 114 V+ DV L L E+C DL+K ++C G + +I+ S L + G+ Sbjct: 69 VKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQIL-SLLSDIGSGI 127 Query: 115 GFCHSRNVLHRDLKPQNLLINRNGE---LKLADFGLARAFGIPVRCYSAEVVTLWYRPPD 171 + H ++HRDLKP+N+++ G K+ D G A+ C + V TL Y P+ Sbjct: 128 RYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGELC-TEFVGTLQYLAPE 186 Query: 172 VLFGAKLYSTSIDMWSAGCIFAELANAGRPLF 203 LF K Y+ ++D WS G + E RP Sbjct: 187 -LFENKPYTATVDYWSFGTMVFECIAGYRPFL 217 >2W1I-A nrPDB Length = 326 Score = 79.7 bits (195), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 58/200 (29%), Positives = 97/200 (48%), Gaps = 15/200 (7%) Query: 7 LEKIGEGTYGTV----FKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62 L+++G+G +G+V + T E+VA+K+ L E REI +LK L+H N Sbjct: 46 LQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKK--LQHSTEEHLRDFEREIEILKSLQHDN 103 Query: 63 IVRLHDVLHS--DKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 IV+ V +S + L L+ E+ L+ Y +D + + Q+ KG+ + + Sbjct: 104 IVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGT 163 Query: 120 RNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYS----AEVVTLWYRPPDVLFG 175 + +HRDL +N+L+ +K+ DFGL + Y E WY P+ L Sbjct: 164 KRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWY-APESLTE 222 Query: 176 AKLYSTSIDMWSAGCIFAEL 195 +K +S + D+WS G + EL Sbjct: 223 SK-FSVASDVWSFGVVLYEL 241 >5TUR-A nrPDB Length = 404 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 63/209 (30%), Positives = 100/209 (47%), Gaps = 12/209 (5%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDD-DDEGVPSSALR---EICLLKEL 58 +Y+ +G G +G+V+ + VA+K V D D G + R E+ LLK++ Sbjct: 128 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 187 Query: 59 KH--KNIVRLHDVLHSDKKLTLVFEFCD--QDLKKYFDSCNGDLDPEIVKSFLFQLLKGL 114 ++RL D L+ E + QDL + G L E+ +SF +Q+L+ + Sbjct: 188 SSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITE-RGALQEELARSFFWQVLEAV 246 Query: 115 GFCHSRNVLHRDLKPQNLLINRN-GELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVL 173 CH+ VLHRD+K +N+LI+ N GELKL DFG V Y+ T Y PP+ + Sbjct: 247 RHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV--YTDFDGTRVYSPPEWI 304 Query: 174 FGAKLYSTSIDMWSAGCIFAELANAGRPL 202 + + S +WS G + ++ P Sbjct: 305 RYHRYHGRSAAVWSLGILLYDMVCGDIPF 333 >4M7I-A nrPDB Length = 299 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 78/313 (24%), Positives = 138/313 (44%), Gaps = 60/313 (19%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 +E ++ +G G +G VF+AKN+ A+KR+RL + E +RE+ L +L+H I Sbjct: 7 FEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNR-ELAREKVMREVKALAKLEHPGI 65 Query: 64 VRLHDVL---HSDKKLT---------LVFEFC-DQDLKKYFDS-CN-GDLDPEIVKSFLF 108 VR + ++ +KL + + C ++LK + + C + + + Sbjct: 66 VRYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFL 125 Query: 109 QLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFG---------IPVRCY- 158 Q+ + + F HS+ ++HRDLKP N+ + +K+ DFGL A P+ Y Sbjct: 126 QIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYA 185 Query: 159 --SAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIF 216 + +V T Y P+ + G YS +D++S G I EL L+P Q++R+ Sbjct: 186 RHTGQVGTKLYMSPEQIHGNS-YSHKVDIFSLGLILFEL------LYP---FSTQMERVR 235 Query: 217 RLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRIS 276 L + P T+ YP +V Q++L +P++R Sbjct: 236 TLTDVRNLKFPPLFTQ--------KYPCEYVMV--------------QDMLSPSPMERPE 273 Query: 277 AEEALQHPYFSDF 289 A +++ F D Sbjct: 274 AINIIENAVFEDL 286 >4J52-A nrPDB Length = 293 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 75/291 (25%), Positives = 121/291 (41%), Gaps = 54/291 (18%) Query: 10 IGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSAL----------REICLLKELK 59 +G+G + F+ + +T E+ A K V P S L EI + + L Sbjct: 22 LGKGGFAKCFEISDADTKEVFAGKIV---------PKSLLLKPHQREKMSMEISIHRSLA 72 Query: 60 HKNIVRLHDVLHSDKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCH 118 H+++V H + + +V E C + L + +PE + +L Q++ G + H Sbjct: 73 HQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPE-ARYYLRQIVLGCQYLH 131 Query: 119 SRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL 178 V+HRDLK NL +N + E+K+ DFGLA T Y P+VL K Sbjct: 132 RNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVL-SKKG 190 Query: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKP 238 +S +D+WS GCI L G+P F + + + RI K +Y Sbjct: 191 HSFEVDVWSIGCIMYTLL-VGKPPFETSCLKETYLRI----------------KKNEYS- 232 Query: 239 YPMYPATTSLVNVVPK-LNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288 +PK +N L+Q +L+ +P R + E L +F+ Sbjct: 233 -------------IPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTS 270 >3I6U-A nrPDB Length = 419 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 76/296 (25%), Positives = 129/296 (43%), Gaps = 50/296 (16%) Query: 10 IGEGTYGTVFKAKNRETHEIVALK-----RVRLDDDDEGVPS-SALREICLLKELKHKNI 63 +G G G V A R+T + VA++ + + E P+ + EI +LK+L H I Sbjct: 143 LGSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSAREADPALNVETEIEILKKLNHPCI 202 Query: 64 VRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGD--LDPEIVKSFLFQLLKGLGFCHSRN 121 +++ + ++ +V E + + FD G+ L K + +Q+L + + H Sbjct: 203 IKIKNFFDAED-YYIVLELMEGG--ELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENG 259 Query: 122 VLHRDLKPQNLLINRNGE---LKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVL--FGA 176 ++HRDLKP+N+L++ E +K+ DFG ++ G T Y P+VL G Sbjct: 260 IIHRDLKPENVLLSSQEEDCLIKITDFGHSKILG-ETSLMRTLCGTPTYLAPEVLVSVGT 318 Query: 177 KLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDY 236 Y+ ++D WS G I + +G P F + LK Sbjct: 319 AGYNRAVDCWSLGVILF-ICLSGYPPFSEHRTQVSLKD---------------------- 355 Query: 237 KPYPMYPATTSLVNVVPKLNA----TGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288 T+ N +P++ A DL++ LL +P R + EEAL+HP+ D Sbjct: 356 ------QITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQD 405 >3DAK-A nrPDB Length = 290 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 76/299 (25%), Positives = 131/299 (43%), Gaps = 40/299 (13%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 YE E IG G V A E VA+KR+ L+ + L+EI + + H NI Sbjct: 12 YELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSM-DELLKEIQAMSQCHHPNI 70 Query: 64 VRLHDVLHSDKKLTLVFEFCDQ----DLKKYF----DSCNGDLDPEIVKSFLFQLLKGLG 115 V + +L LV + D+ K+ + +G LD + + L ++L+GL Sbjct: 71 VSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEGLE 130 Query: 116 FCHSRNVLHRDLKPQNLLINRNGELKLADFGLAR--AFGIPV---RCYSAEVVTLWYRPP 170 + H +HRD+K N+L+ +G +++ADFG++ A G + + V T + P Sbjct: 131 YLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWMAP 190 Query: 171 DVLFGAKLYSTSIDMWSAGCIFAELANAGRPL--FPGNDVDDQLKRIFRLLGTPTEEQWP 228 +V+ + Y D+WS G ELA P +P ++L + P Sbjct: 191 EVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPP----------MKVLMLTLQNDPP 240 Query: 229 SM-TKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286 S+ T + D + ++ K + R ++ L+ +P +R +A E L+H +F Sbjct: 241 SLETGVQDKE-------------MLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFF 286 >5X8I-B nrPDB Length = 346 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 90/333 (27%), Positives = 146/333 (43%), Gaps = 64/333 (19%) Query: 3 KYEKLEKIGEGTYGTVF-----KAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKE 57 +YE ++ +GEG +G V KA R VA+K V+ + + +A EI +L+ Sbjct: 14 RYEIVDTLGEGAFGKVVECIDHKAGGRH----VAVKIVK---NVDRYCEAARSEIQVLEH 66 Query: 58 LKHKN------IVRLHDVLHSDKKLTLVFEFCDQDLKKY-FDSCNGDLDPEI--VKSFLF 108 L + V++ + + +VFE L Y F NG L + ++ + Sbjct: 67 LNTTDPNSTFRCVQMLEWFEHHGHICIVFELLG--LSTYDFIKENGFLPFRLDHIRKMAY 124 Query: 109 QLLKGLGFCHSRNVLHRDLKPQNLL-------------INR------NGELKLADFGLAR 149 Q+ K + F HS + H DLKP+N+L I R N ++K+ DFG A Sbjct: 125 QICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSA- 183 Query: 150 AFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVD 209 +S V T YR P+V+ A +S D+WS GCI E G +FP +D Sbjct: 184 --TYDDEHHSTLVSTRHYRAPEVIL-ALGWSQPCDVWSIGCILIEYY-LGFTVFPTHDSK 239 Query: 210 DQLKRIFRLLG-------TPTEEQ---------WPSMTKLPDYKPYPMYPATTSLVNVVP 253 + L + R+LG T ++ W + Y P +++ Sbjct: 240 EHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQDV 299 Query: 254 KLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286 + + DL+Q +L+ +P +RI+ EAL+HP+F Sbjct: 300 E-HERLFDLIQKMLEYDPAKRITLREALKHPFF 331 >2DQ7-X nrPDB Length = 283 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 65/223 (29%), Positives = 112/223 (50%), Gaps = 22/223 (9%) Query: 7 LEKIGEGTYGTVFKAK-NRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVR 65 ++++G G +G V+ N T VA+K ++ P S L E ++K+LKH +V+ Sbjct: 14 IKRLGNGQFGEVWMGTWNGNTK--VAIKTLKPGTMS---PESFLEEAQIMKKLKHDKLVQ 68 Query: 66 LHDVLHSDKKLTLVFEFCDQ-DLKKYFDSCNGDLD--PEIVKSFLFQLLKGLGFCHSRNV 122 L+ V+ S++ + +V E+ ++ L + G P +V Q+ G+ + N Sbjct: 69 LYAVV-SEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLV-DMAAQVAAGMAYIERMNY 126 Query: 123 LHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYS----AEVVTLWYRPPDVLFGAKL 178 +HRDL+ N+L+ K+ADFGLAR I Y+ A+ W P L+G Sbjct: 127 IHRDLRSANILVGNGLICKIADFGLARL--IEDNEYTARQGAKFPIKWTAPEAALYGR-- 182 Query: 179 YSTSIDMWSAGCIFAELANAGRPLFPG---NDVDDQLKRIFRL 218 ++ D+WS G + EL GR +PG +V +Q++R +R+ Sbjct: 183 FTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRM 225 >2OU7-A nrPDB Length = 335 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 75/291 (25%), Positives = 121/291 (41%), Gaps = 54/291 (18%) Query: 10 IGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSAL----------REICLLKELK 59 +G+G + F+ + +T E+ A K V P S L EI + + L Sbjct: 49 LGKGGFAKCFEISDADTKEVFAGKIV---------PKSLLLKPHQREKMSMEISIHRSLA 99 Query: 60 HKNIVRLHDVLHSDKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCH 118 H+++V H + + +V E C + L + +PE + +L Q++ G + H Sbjct: 100 HQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPE-ARYYLRQIVLGCQYLH 158 Query: 119 SRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL 178 V+HRDLK NL +N + E+K+ DFGLA T Y P+VL K Sbjct: 159 RNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVL-SKKG 217 Query: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKP 238 +S +D+WS GCI L G+P F + + + RI K +Y Sbjct: 218 HSFEVDVWSIGCIMYTLL-VGKPPFETSCLKETYLRI----------------KKNEYS- 259 Query: 239 YPMYPATTSLVNVVPK-LNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288 +PK +N L+Q +L+ +P R + E L +F+ Sbjct: 260 -------------IPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTS 297 >3A4O-X nrPDB Length = 286 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 62/224 (27%), Positives = 115/224 (51%), Gaps = 23/224 (10%) Query: 7 LEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPS--SALREICLLKELKHKNIV 64 ++++G G +G V+ + + VA+K ++ G S + L E L+K L+H +V Sbjct: 18 VKRLGAGQFGEVWMGYYNNSTK-VAVKTLK-----PGTMSVQAFLEEANLMKTLQHDKLV 71 Query: 65 RLHDVLHSDKKLTLVFEFCDQ-DLKKYFDSCNGD--LDPEIVKSFLFQLLKGLGFCHSRN 121 RL+ V+ ++ + ++ E+ + L + S G L P+++ F Q+ +G+ + +N Sbjct: 72 RLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLI-DFSAQIAEGMAYIERKN 130 Query: 122 VLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYS----AEVVTLWYRPPDVLFGAK 177 +HRDL+ N+L++ + K+ADFGLAR I Y+ A+ W P + FG Sbjct: 131 YIHRDLRAANVLVSESLMCKIADFGLARV--IEDNEYTAREGAKFPIKWTAPEAINFGC- 187 Query: 178 LYSTSIDMWSAGCIFAELANAGRPLFPGN---DVDDQLKRIFRL 218 ++ D+WS G + E+ G+ +PG DV L + +R+ Sbjct: 188 -FTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRM 230 >4RC3-A nrPDB Length = 289 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 63/209 (30%), Positives = 100/209 (47%), Gaps = 12/209 (5%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDD-DDEGVPSSALR---EICLLKEL 58 +Y+ +G G +G+V+ + VA+K V D D G + R E+ LLK++ Sbjct: 13 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 72 Query: 59 KH--KNIVRLHDVLHSDKKLTLVFEFCD--QDLKKYFDSCNGDLDPEIVKSFLFQLLKGL 114 ++RL D L+ E + QDL + G L E+ +SF +Q+L+ + Sbjct: 73 SSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITE-RGALQEELARSFFWQVLEAV 131 Query: 115 GFCHSRNVLHRDLKPQNLLINRN-GELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVL 173 CH+ VLHRD+K +N+LI+ N GELKL DFG V Y+ T Y PP+ + Sbjct: 132 RHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV--YTDFDGTRVYSPPEWI 189 Query: 174 FGAKLYSTSIDMWSAGCIFAELANAGRPL 202 + + S +WS G + ++ P Sbjct: 190 RYHRYHGRSAAVWSLGILLYDMVCGDIPF 218 >3IO7-A nrPDB Length = 313 Score = 79.0 bits (193), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 58/200 (29%), Positives = 97/200 (48%), Gaps = 15/200 (7%) Query: 7 LEKIGEGTYGTV----FKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62 L+++G+G +G+V + T E+VA+K+ L E REI +LK L+H N Sbjct: 33 LQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKK--LQHSTEEHLRDFEREIEILKSLQHDN 90 Query: 63 IVRLHDVLHS--DKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 IV+ V +S + L L+ E+ L+ Y +D + + Q+ KG+ + + Sbjct: 91 IVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGT 150 Query: 120 RNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYS----AEVVTLWYRPPDVLFG 175 + +HRDL +N+L+ +K+ DFGL + Y E WY P+ L Sbjct: 151 KRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWY-APESLTE 209 Query: 176 AKLYSTSIDMWSAGCIFAEL 195 +K +S + D+WS G + EL Sbjct: 210 SK-FSVASDVWSFGVVLYEL 228 >3BGP-A nrPDB Length = 333 Score = 79.0 bits (193), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 63/209 (30%), Positives = 100/209 (47%), Gaps = 12/209 (5%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDD-DDEGVPSSALR---EICLLKEL 58 +Y+ +G G +G+V+ + VA+K V D D G + R E+ LLK++ Sbjct: 57 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 116 Query: 59 KH--KNIVRLHDVLHSDKKLTLVFEFCD--QDLKKYFDSCNGDLDPEIVKSFLFQLLKGL 114 ++RL D L+ E + QDL + G L E+ +SF +Q+L+ + Sbjct: 117 SSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITE-RGALQEELARSFFWQVLEAV 175 Query: 115 GFCHSRNVLHRDLKPQNLLINRN-GELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVL 173 CH+ VLHRD+K +N+LI+ N GELKL DFG V Y+ T Y PP+ + Sbjct: 176 RHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV--YTDFDGTRVYSPPEWI 233 Query: 174 FGAKLYSTSIDMWSAGCIFAELANAGRPL 202 + + S +WS G + ++ P Sbjct: 234 RYHRYHGRSAAVWSLGILLYDMVCGDIPF 262 >5EG3-A nrPDB Length = 334 Score = 79.0 bits (193), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 63/236 (26%), Positives = 112/236 (47%), Gaps = 32/236 (13%) Query: 10 IGEGTYGTVFKA------KNRETHEIVALKRVRLDDDDEGVPSSALREICLLKEL-KHKN 62 +GEG +G V A K++ + ++ DD E S + E+ ++K + KHKN Sbjct: 43 LGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKN 102 Query: 63 IVRLHDVLHSDKKLTLVFEFCDQ-DLKKYFDS---CNGDLDPEIVK------------SF 106 I+ L D L ++ + + +L++Y + +L P+I + S Sbjct: 103 IINLLGACTQDGPLYVIVAYASKGNLREYLRARRPPGMELSPDINRVPEEQMTFKDLVSC 162 Query: 107 LFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFG---IPVRCYSAEVV 163 +QL +G+ + S+ +HRDL +N+L+ N +K+ADFGLAR + + Sbjct: 163 TYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDFFKETTNGRLP 222 Query: 164 TLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLL 219 W P+ LF ++Y+ D+WS G + E+ G +PG V++ +F+LL Sbjct: 223 VKWM-APEALFD-RVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEE----LFKLL 272 >3DB8-A nrPDB Length = 317 Score = 79.0 bits (193), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 77/304 (25%), Positives = 127/304 (41%), Gaps = 54/304 (17%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSAL----------R 50 M++Y + +G+G + ++ + +T E+ A K V P S L Sbjct: 41 MKRYMRGRFLGKGGFAKCYEITDMDTKEVFAGKVV---------PKSMLLKPHQKEKMST 91 Query: 51 EICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFLFQ 109 EI + K L + ++V H D + +V E C + L + +PE + F+ Q Sbjct: 92 EIAIHKSLDNPHVVGFHGFFEDDDFVYVVLEICRRRSLLELHKRRKAVTEPE-ARYFMRQ 150 Query: 110 LLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRP 169 ++G+ + H+ V+HRDLK NL +N + ++K+ DFGLA T Y Sbjct: 151 TIQGVQYLHNNRVIHRDLKLGNLFLNDDMDVKIGDFGLATKIEFDGERKKDLCGTPNYIA 210 Query: 170 PDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPS 229 P+VL K +S +D+WS GCI L G+P F + + + RI Sbjct: 211 PEVL-CKKGHSFEVDIWSLGCILYTLL-VGKPPFETSCLKETYIRI-------------- 254 Query: 230 MTKLPDYKPYPMYPATTSLVNVVPK-LNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288 K +Y VP+ +N L++ +L +P R S E L +F+ Sbjct: 255 --KKNEYS--------------VPRHINPVASALIRRMLHADPTLRPSVAELLTDEFFTS 298 Query: 289 FCPP 292 P Sbjct: 299 GYAP 302 >3TXO-A nrPDB Length = 353 Score = 79.0 bits (193), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 70/302 (23%), Positives = 128/302 (42%), Gaps = 51/302 (16%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVR----LDDDDEGVPSSALREICLLK 56 + +E + +G+G++G V A+ +ET ++ A+K ++ L DDD + R + L + Sbjct: 22 IDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLAR 81 Query: 57 ELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGF 116 H + +L + +L V EF + + + D + + +++ L F Sbjct: 82 --NHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMF 139 Query: 117 CHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLW----YRPPDV 172 H + +++RDLK N+L++ G KLADFG+ + GI C T Y P++ Sbjct: 140 LHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKE-GI---CNGVTTATFCGTPDYIAPEI 195 Query: 173 LFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTK 232 L LY ++D W+ G + E+ P F + DD + I Sbjct: 196 L-QEMLYGPAVDWWAMGVLLYEMLCGHAP-FEAENEDDLFEAI----------------- 236 Query: 233 LPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISA------EEALQHPYF 286 L D YP + L+ +L++ + NP R+ + L+HP+F Sbjct: 237 LNDEVVYPTW------------LHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFF 284 Query: 287 SD 288 + Sbjct: 285 KE 286 >4JG6-A nrPDB Length = 355 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 76/302 (25%), Positives = 131/302 (43%), Gaps = 63/302 (20%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 YE E IG G+Y + ++ T+ A+K + D + P+ + LL+ +H NI Sbjct: 37 YEVKEDIGVGSYSVCKRCIHKATNMEFAVKII---DKSKRDPTEEIE--ILLRYGQHPNI 91 Query: 64 VRLHDVLHSDKKLTLVFEFC------DQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFC 117 + L DV K + +V E D+ L++ F S + LF + K + + Sbjct: 92 ITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFS------EREASAVLFTITKTVEYL 145 Query: 118 HSRNVLHRDLKPQNLL-INRNG---ELKLADFGLARAFG-----IPVRCYSAEVVTLWYR 168 H++ V+HRDLKP N+L ++ +G +++ DFG A+ + CY+A V Sbjct: 146 HAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVA---- 201 Query: 169 PPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTP----TE 224 P+VL + Y + D+WS G + + P N DD + I +G+ + Sbjct: 202 -PEVL-ERQGYDAACDIWSLGVLLYTMLTGYTPF--ANGPDDTPEEILARIGSGKFSLSG 257 Query: 225 EQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHP 284 W S++ T +DL+ +L +P QR++A L+HP Sbjct: 258 GYWNSVSD-------------------------TAKDLVSKMLHVDPHQRLTAALVLRHP 292 Query: 285 YF 286 + Sbjct: 293 WI 294 >5YV8-A nrPDB Length = 298 Score = 78.6 bits (192), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 74/315 (23%), Positives = 131/315 (41%), Gaps = 57/315 (18%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDD--------------------- 39 + +Y ++IG+G+YG V A N + A+K + Sbjct: 12 LNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPG 71 Query: 40 ---DDEGVPSSALREICLLKELKHKNIVRLHDVLH--SDKKLTLVFEFCDQDLKKYFDSC 94 G +EI +LK+L H N+V+L +VL ++ L +VFE +Q + Sbjct: 72 GCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTL 131 Query: 95 NGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIP 154 L + + + L+KG+ + H + ++HRD+KP NLL+ +G +K+ADFG++ F Sbjct: 132 K-PLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGS 190 Query: 155 VRCYSAEVVTLWYRPPDVLFGA-KLYS-TSIDMWSAGCIFAELANAGRPLFPGNDVDDQL 212 S V T + P+ L K++S ++D+W+ G P +D+++ Sbjct: 191 DALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPF-----MDERI 245 Query: 213 KRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPV 272 + + + E PD P + +DL+ +L NP Sbjct: 246 MCLHSKIKSQALE-------FPDQ----------------PDIAEDLKDLITRMLDKNPE 282 Query: 273 QRISAEEALQHPYFS 287 RI E HP+ + Sbjct: 283 SRIVVPEIKLHPWVT 297 >4UYA-A nrPDB Length = 340 Score = 78.6 bits (192), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 60/212 (28%), Positives = 93/212 (43%), Gaps = 17/212 (8%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 ++ E E IG G +G V++A + V R + D S RE L L+H Sbjct: 26 ERLELKELIGAGGFGQVYRATWQGQEVAVKAARQDPEQDAAAAAESVRREARLFAMLRHP 85 Query: 62 NIVRLHDVLHSDKKLTLVFEFC-DQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 NI+ L V L LV EF L + + P ++ ++ Q+ +G+ + H Sbjct: 86 NIIELRGVCLQQPHLCLVLEFARGGALNRAL--AGRRIPPHVLVNWAVQIARGMLYLHEE 143 Query: 121 N---VLHRDLKPQNLLINR--------NGELKLADFGLARAFGIPVRCYSAEVVTLWYRP 169 +LHRDLK N+L+ N LK+ DFGLAR + + +A + Sbjct: 144 AFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTKMATAGAYA--WMA 201 Query: 170 PDVLFGAKLYSTSIDMWSAGCIFAELANAGRP 201 P+V+ + L+S D+WS G + EL P Sbjct: 202 PEVI-KSSLFSKGSDIWSYGVLLWELLTGEVP 232 >5FET-A nrPDB Length = 847 Score = 78.2 bits (191), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 69/223 (30%), Positives = 108/223 (48%), Gaps = 18/223 (8%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 M + E IG GT+GTV ++ T ALK V + + I L +E+ Sbjct: 532 MHELETERIIGRGTFGTVKLVHHKPTQIRYALKCV---SKRSIISLNQQNNIKLEREITA 588 Query: 61 KN----IVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCN--GDLDPEIVKSFLFQLLKGL 114 +N I+RL + E + +D+ G L + +L ++ + Sbjct: 589 ENDHPFIIRLVRTFKDSNCFYFLTELVTGG--ELYDAIRKLGLLSKPQAQFYLGSIILAI 646 Query: 115 GFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLF 174 + H RN+++RDLKP+N+L+++ G +KL DFG A+ I R Y+ V T Y P+V+ Sbjct: 647 EYLHERNIVYRDLKPENILLDKQGYVKLIDFGCAKK--IQGRAYTL-VGTPHYMAPEVIL 703 Query: 175 GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFR 217 G K Y ++D+W+ G E PL GND +DQL+ IFR Sbjct: 704 G-KGYGCTVDIWALGVCLYEFICG--PLPFGNDQEDQLE-IFR 742 >3HDN-A nrPDB Length = 373 Score = 77.8 bits (190), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 72/290 (24%), Positives = 127/290 (43%), Gaps = 43/290 (14%) Query: 7 LEKIGEGTYGTVFKAKNRETHEIVALKRVR----LDDDDEGVPSSALREICLLKELKHKN 62 L+ IG+G++G V A+++ A+K ++ L +E S LLK +KH Sbjct: 43 LKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERN--VLLKNVKHPF 100 Query: 63 IVRLHDVLHSDKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN 121 +V LH + KL V ++ + +L + L+P + + ++ LG+ HS N Sbjct: 101 LVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPR-ARFYAAEIASALGYLHSLN 159 Query: 122 VLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYST 181 +++RDLKP+N+L++ G + L DFGL + S T Y P+VL + Y Sbjct: 160 IVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLH-KQPYDR 218 Query: 182 SIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPM 241 ++D W G + E+ P + N T E + ++ P Sbjct: 219 TVDWWCLGAVLYEMLYGLPPFYSRN----------------TAEMYDNILNKP------- 255 Query: 242 YPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAE----EALQHPYFS 287 + + P + + R LL+ LL+ + +R+ A+ E H +FS Sbjct: 256 -------LQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFS 298 >1PHK-A nrPDB Length = 298 Score = 77.8 bits (190), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 75/304 (24%), Positives = 132/304 (43%), Gaps = 46/304 (15%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLD-------DDDEGVPSSALREICL 54 + YE E +G G V + ++ T + A+K + + ++ + + + L+E+ + Sbjct: 17 ENYEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQELREATLKEVDI 76 Query: 55 LKELK-HKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKG 113 L+++ H NI++L D ++ LVF+ + + + L + + + LL+ Sbjct: 77 LRKVSGHPNIIQLKDTYETNTFFFLVFDLMKKGELFDYLTEKVTLSEKETRKIMRALLEV 136 Query: 114 LGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVL 173 + H N++HRDLKP+N+L++ + +KL DFG + P T Y P+++ Sbjct: 137 ICALHKLNIVHRDLKPENILLDDDMNIKLTDFGFSCQLD-PGEKLREVCGTPSYLAPEII 195 Query: 174 FGAK-----LYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFR---LLGTPTEE 225 + Y +DMWS G I L AG P F L+ I G+P Sbjct: 196 ECSMNDNHPGYGKEVDMWSTGVIMYTLL-AGSPPFWHRKQMLMLRMIMSGNYQFGSP--- 251 Query: 226 QWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPY 285 +W DY + T +DL+ L P +R +AEEAL HP+ Sbjct: 252 EW------DDY-------------------SDTVKDLVSRFLVVQPQKRYTAEEALAHPF 286 Query: 286 FSDF 289 F + Sbjct: 287 FQQY 290 >6CCF-A nrPDB Length = 290 Score = 77.8 bits (190), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 74/315 (23%), Positives = 133/315 (42%), Gaps = 57/315 (18%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRV-----------------RLDDDDEG 43 + +Y+ +IG+G YG V A N A+K + R +G Sbjct: 4 LNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQG 63 Query: 44 VPSSAL-------REICLLKELKHKNIVRLHDVLH--SDKKLTLVFEFCDQDLKKYFDSC 94 P+ L +EI +LK+L H N+V+L +VL ++ L LVF+ + C Sbjct: 64 GPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEV-PC 122 Query: 95 NGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIP 154 + E + +L ++ GL + H + ++HRD+KP NLL+ +G +K+ADFG++ F Sbjct: 123 DKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGN 182 Query: 155 VRCYSAEVVTLWYRPPDVL--FGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQL 212 S+ T + P+ + G ++D+W+ G P +DD + Sbjct: 183 DAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPF-----IDDFI 237 Query: 213 KRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPV 272 + R + +P ++P P+++ +DL+ +L NP Sbjct: 238 LALHRKIKN---------------EPV-VFPEE-------PEISEELKDLILKMLDKNPE 274 Query: 273 QRISAEEALQHPYFS 287 RI + HP+ + Sbjct: 275 TRIGVPDIKLHPWVT 289 >3TT0-A nrPDB Length = 382 Score = 77.8 bits (190), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 66/239 (27%), Positives = 118/239 (49%), Gaps = 38/239 (15%) Query: 10 IGEGTYGTVFKAK---------NRETHEIVALKRVRLDDDDEGVPSSALREICLLKEL-K 59 +GEG +G V A+ NR T VA+K ++ D ++ + S + E+ ++K + K Sbjct: 77 LGEGAFGQVVLAEAIGLDKDKPNRVTK--VAVKMLKSDATEKDL-SDLISEMEMMKMIGK 133 Query: 60 HKNIVRLHDVLHSDKKLTLVFEFCDQ-DLKKYFD---------SCNGDLDPEI------V 103 HKNI+ L D L ++ E+ + +L++Y S N +PE + Sbjct: 134 HKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYSYNPSHNPEEQLSSKDL 193 Query: 104 KSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLAR---AFGIPVRCYSA 160 S +Q+ +G+ + S+ +HRDL +N+L+ + +K+ADFGLAR + + Sbjct: 194 VSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNG 253 Query: 161 EVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLL 219 + W P+ LF ++Y+ D+WS G + E+ G +PG V++ +F+LL Sbjct: 254 RLPVKWM-APEALFD-RIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEE----LFKLL 306 >3FXW-A nrPDB Length = 336 Score = 77.8 bits (190), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 77/304 (25%), Positives = 127/304 (41%), Gaps = 74/304 (24%) Query: 10 IGEGTYGTVFKAKNRETHEIVALK------RVRLDDDDEGVPSSALREICLLKELKHKNI 63 +G G G V + +R T + ALK + R + D S +C+L Sbjct: 37 LGLGVNGKVLECFHRRTGQKCALKLLYDSPKARQEVDHHWQASGGPHIVCILD------- 89 Query: 64 VRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLG----FCHS 119 +++ +H K+ L+ C + + F D + ++++ +G F HS Sbjct: 90 --VYENMHHGKRCLLIIMEC-MEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLHS 146 Query: 120 RNVLHRDLKPQNLLIN---RNGELKLADFGLARAF---GIPVRCYSAEVVTLWYRPPDVL 173 N+ HRD+KP+NLL ++ LKL DFG A+ + CY T +Y P+VL Sbjct: 147 HNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNALQTPCY-----TPYYVAPEVL 201 Query: 174 FGAKLYSTSIDMWSAGCIFAEL--------ANAGRPLFPGNDVDDQLKRIFRL--LGTPT 223 G + Y S DMWS G I L +N G+ + PG +KR RL G P Sbjct: 202 -GPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPG------MKRRIRLGQYGFPN 254 Query: 224 EEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQH 283 E W +++ + L++ LLK +P +R++ + + H Sbjct: 255 PE-WSEVSE-------------------------DAKQLIRLLLKTDPTERLTITQFMNH 288 Query: 284 PYFS 287 P+ + Sbjct: 289 PWIN 292 >1FOT-A nrPDB Length = 318 Score = 77.4 bits (189), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 70/308 (22%), Positives = 136/308 (44%), Gaps = 68/308 (22%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICL-LKELK 59 +Q ++ L +G G++G V ++R A+K ++ +EI + LK+++ Sbjct: 5 LQDFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLK-------------KEIVVRLKQVE 51 Query: 60 HKN-------------IVRLHDVLHSDKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEIVKS 105 H N I+R+ +++ ++ ++ + +L +P + K Sbjct: 52 HTNDERLMLSIVTHPFIIRMWGTFQDAQQIFMIMDYIEGGELFSLLRKSQRFPNP-VAKF 110 Query: 106 FLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTL 165 + ++ L + HS+++++RDLKP+N+L+++NG +K+ DFG A+ +P Y+ T Sbjct: 111 YAAEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKY--VPDVTYTL-CGTP 167 Query: 166 WYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEE 225 Y P+V+ K Y+ SID WS G + E+ P + N +K ++L E Sbjct: 168 DYIAPEVV-STKPYNKSIDWWSFGILIYEMLAGYTPFYDSN----TMKTYEKILN--AEL 220 Query: 226 QWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRI-----SAEEA 280 ++P P N +DLL L+ + QR+ E+ Sbjct: 221 RFP------------------------PFFNEDVKDLLSRLITRDLSQRLGNLQNGTEDV 256 Query: 281 LQHPYFSD 288 HP+F + Sbjct: 257 KNHPWFKE 264 >5MJB-A nrPDB Length = 305 Score = 77.0 bits (188), Expect = 9e-15, Method: Compositional matrix adjust. Identities = 58/226 (25%), Positives = 108/226 (47%), Gaps = 20/226 (8%) Query: 8 EKIGEGTYGTVFKAK-----NRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62 E IG G +G V+K + RE + VA+K ++ E L E ++ + H+N Sbjct: 32 EVIGAGEFGEVYKGRLKLPGKREIY--VAIKTLKAGYS-EKQRRDFLSEASIMGQFDHRN 88 Query: 63 IVRLHDVLHSDKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN 121 I+RL V+ + + ++ EF + L + +G + L + G+ + N Sbjct: 89 IIRLEGVVTKSRPVMIITEFMENCALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLSEMN 148 Query: 122 VLHRDLKPQNLLINRNGELKLADFGLARAF----GIPVRCYS--AEVVTLWYRPPDVLFG 175 +HRDL +N+L+N N K++DFGL+R P S ++ W P + + Sbjct: 149 YVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIAY- 207 Query: 176 AKLYSTSIDMWSAGCIFAELANAG-RPLF--PGNDVDDQLKRIFRL 218 + ++++ D+WS G + E+ + G RP + DV + +++ +RL Sbjct: 208 -RKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRL 252 >4XCU-A nrPDB Length = 300 Score = 77.0 bits (188), Expect = 9e-15, Method: Compositional matrix adjust. Identities = 57/219 (26%), Positives = 111/219 (50%), Gaps = 21/219 (9%) Query: 10 IGEGTYGTVFKAK-------NRETHEIVALKRVRLDDDDEGVPSSALREICLLKEL-KHK 61 +GEG +G V +A+ + VA+K ++ + D+ + + + E+ ++K + +HK Sbjct: 25 LGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDL-ADLVSEMEVMKLIGRHK 83 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQ-DLKKYF------DSCNGDLDPEIVKSFLFQLLKGL 114 NI+ L V + L ++ E + +L+++ S G L ++ S +Q+ +G+ Sbjct: 84 NIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGSSEGPLSFPVLVSCAYQVARGM 143 Query: 115 GFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARA---FGIPVRCYSAEVVTLWYRPPD 171 + SR +HRDL +N+L+ + +K+ADFGLAR + + + W P+ Sbjct: 144 QYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWM-APE 202 Query: 172 VLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDD 210 LF ++Y+ D+WS G + E+ G +PG V++ Sbjct: 203 ALFD-RVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEE 240 >1VZO-A nrPDB Length = 355 Score = 77.0 bits (188), Expect = 9e-15, Method: Compositional matrix adjust. Identities = 70/301 (23%), Positives = 134/301 (44%), Gaps = 41/301 (13%) Query: 1 MQKYEKLEKIGEGTYGTVF---KAKNRETHEIVALKRVRLDDDDEGVPSS--ALREICLL 55 ++ +E L+ +G G YG VF K +T ++ A+K ++ + ++ E +L Sbjct: 53 IENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVL 112 Query: 56 KELKHKN-IVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGL 114 + ++ +V LH ++ KL L+ ++ + S V+ ++ +++ L Sbjct: 113 EHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLAL 172 Query: 115 GFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGI--PVRCYSAEVVTLWYRPPDV 172 H +++RD+K +N+L++ NG + L DFGL++ F R Y T+ Y PD+ Sbjct: 173 EHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYDF-CGTIEYMAPDI 231 Query: 173 LFGA-KLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMT 231 + G + ++D WS G + EL P + + Q + R+L Sbjct: 232 VRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRIL------------ 279 Query: 232 KLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRIS-----AEEALQHPYF 286 K P YP +++A +DL+Q LL +P +R+ A+E +H +F Sbjct: 280 -----KSEPPYP---------QEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFF 325 Query: 287 S 287 Sbjct: 326 Q 326 >2JDO-A nrPDB Length = 342 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 69/297 (23%), Positives = 135/297 (45%), Gaps = 47/297 (15%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLD---DDDEGVPSSALREICLLKE 57 M ++ L+ +G+GT+G V + + T A+K +R + DE + + E +L+ Sbjct: 9 MNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDE--VAHTVTESRVLQN 66 Query: 58 LKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFC 117 +H + L + +L V E+ + + S E + + +++ L + Sbjct: 67 TRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYL 126 Query: 118 HSRNVLHRDLKPQNLLINRNGELKLADFGLAR---AFGIPVRCYSAEVVTLWYRPPDVLF 174 HSR+V++RD+K +NL+++++G +K+ DFGL + + G ++ + T Y P+VL Sbjct: 127 HSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCG---TPEYLAPEVLE 183 Query: 175 GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLP 234 Y ++D W G + E+ P + + +R+F L+ M ++ Sbjct: 184 DND-YGRAVDWWGLGVVMYEMMCGRLPFY-----NQDHERLFELI---------LMEEI- 227 Query: 235 DYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRIS-----AEEALQHPYF 286 +P T L+ + LL LLK +P QR+ A+E ++H +F Sbjct: 228 ------RFPRT---------LSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFF 269 >5UUU-A nrPDB Length = 547 Score = 76.6 bits (187), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 54/201 (26%), Positives = 99/201 (49%), Gaps = 14/201 (6%) Query: 10 IGEGTYGTVFKAKNRETHEIVALK-----RVRLDDDDEGVPSSALREICLLKELKHKN-- 62 IG G +G V+ + +T ++ A+K R+++ + + AL E +L + + Sbjct: 206 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGE----TLALNERIMLSLVSTGDCP 261 Query: 63 -IVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN 121 IV + H+ KL+ + + + Y S +G ++ + +++ GL H+R Sbjct: 262 FIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRF 321 Query: 122 VLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYST 181 V++RDLKP N+L++ +G ++++D GLA F + A V T Y P+VL Y + Sbjct: 322 VVYRDLKPANILLDEHGHVRISDLGLACDFS--KKKPHASVGTHGYMAPEVLQKGVAYDS 379 Query: 182 SIDMWSAGCIFAELANAGRPL 202 S D +S GC+ +L P Sbjct: 380 SADWFSLGCMLFKLLRGHSPF 400 >1LUF-A nrPDB Length = 343 Score = 76.6 bits (187), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 62/236 (26%), Positives = 105/236 (44%), Gaps = 53/236 (22%) Query: 5 EKLEKIGEGTYGTVFKAKN-----RETHEIVALKRVRLDDDDEGVPSSALREICLLKELK 59 E + IGEG +G VF+A+ E +VA+K ++ ++ + + RE L+ E Sbjct: 50 EYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLK-EEASADMQADFQREAALMAEFD 108 Query: 60 HKNIVRLHDVLHSDKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFLF---------- 108 + NIV+L V K + L+FE+ DL ++ S + P V S Sbjct: 109 NPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRS----MSPHTVCSLSHSDLSTRARVS 164 Query: 109 -----------------QLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAF 151 Q+ G+ + R +HRDL +N L+ N +K+ADFGL+R Sbjct: 165 SPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNI 224 Query: 152 GIPVRCYSA--------EVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAG 199 YSA + + + + PP+ +F + Y+T D+W+ G + E+ + G Sbjct: 225 ------YSADYYKADGNDAIPIRWMPPESIFYNR-YTTESDVWAYGVVLWEIFSYG 273 >3GQL-A nrPDB Length = 326 Score = 76.6 bits (187), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 66/239 (27%), Positives = 119/239 (49%), Gaps = 38/239 (15%) Query: 10 IGEGTYGTVFKAK---------NRETHEIVALKRVRLDDDDEGVPSSALREICLLKEL-K 59 +GEG +G V A+ NR T VA+K ++ D ++ + S + E+ ++K + K Sbjct: 36 LGEGAFGQVVLAEAIGLDKDKPNRVTK--VAVKMLKSDATEKDL-SDLISEMEMMKMIGK 92 Query: 60 HKNIVRLHDVLHSDKKLTLVFEFCDQ-DLKKYFDS--------C-NGDLDPEI------V 103 HKNI+ L D L ++ E+ + +L++Y + C N +PE + Sbjct: 93 HKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDL 152 Query: 104 KSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLAR---AFGIPVRCYSA 160 S +Q+ +G+ + S+ +HRDL +N+L+ + +K+ADFGLAR + + Sbjct: 153 VSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNG 212 Query: 161 EVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLL 219 + W P+ LF ++Y+ D+WS G + E+ G +PG V++ +F+LL Sbjct: 213 RLPVKWM-APEALFD-RIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEE----LFKLL 265 >4FR4-A nrPDB Length = 384 Score = 76.3 bits (186), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 69/289 (23%), Positives = 123/289 (42%), Gaps = 32/289 (11%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDD-DDEGVPSSALREICLLKELKHKN 62 +E L IG+G++G V + +T ++ A+K + + + +E+ +++ L+H Sbjct: 17 FEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQGLEHPF 76 Query: 63 IVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNV 122 +V L ++ + +V + +Y N E VK F+ +L+ L + ++ + Sbjct: 77 LVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELVMALDYLQNQRI 136 Query: 123 LHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAK--LYS 180 +HRD+KP N+L++ +G + + DF +A + + T Y P++ K YS Sbjct: 137 IHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQI-TTMAGTKPYMAPEMFSSRKGAGYS 195 Query: 181 TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYP 240 ++D WS G EL RP + K I T Sbjct: 196 FAVDWWSLGVTAYELLRGRRPYHIRSSTSS--KEIVHTFETTV----------------V 237 Query: 241 MYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQH-PYFSD 288 YP+ S V LL+ LL+ NP QR S +Q+ PY +D Sbjct: 238 TYPSAWSQEMV---------SLLKKLLEPNPDQRFSQLSDVQNFPYMND 277 >5A46-A nrPDB Length = 386 Score = 76.3 bits (186), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 66/239 (27%), Positives = 119/239 (49%), Gaps = 38/239 (15%) Query: 10 IGEGTYGTVFKAK---------NRETHEIVALKRVRLDDDDEGVPSSALREICLLKEL-K 59 +GEG +G V A+ NR T VA+K ++ D ++ + S + E+ ++K + K Sbjct: 48 LGEGCFGQVVLAEAIGLDKDKPNRVTK--VAVKMLKSDATEKDL-SDLISEMEMMKMIGK 104 Query: 60 HKNIVRLHDVLHSDKKLTLVFEFCDQ-DLKKYFDS--------C-NGDLDPEI------V 103 HKNI+ L D L ++ E+ + +L++Y + C N +PE + Sbjct: 105 HKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDL 164 Query: 104 KSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLAR---AFGIPVRCYSA 160 S +Q+ +G+ + S+ +HRDL +N+L+ + +K+ADFGLAR + + Sbjct: 165 VSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNG 224 Query: 161 EVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLL 219 + W P+ LF ++Y+ D+WS G + E+ G +PG V++ +F+LL Sbjct: 225 RLPVKWM-APEALFD-RIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEE----LFKLL 277 >3PVW-A nrPDB Length = 695 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 54/201 (26%), Positives = 99/201 (49%), Gaps = 14/201 (6%) Query: 10 IGEGTYGTVFKAKNRETHEIVALK-----RVRLDDDDEGVPSSALREICLLKELKHKN-- 62 IG G +G V+ + +T ++ A+K R+++ + + AL E +L + + Sbjct: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGE----TLALNERIMLSLVSTGDCP 252 Query: 63 -IVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN 121 IV + H+ KL+ + + + Y S +G ++ + +++ GL H+R Sbjct: 253 FIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRF 312 Query: 122 VLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYST 181 V++RDLKP N+L++ +G ++++D GLA F + A V T Y P+VL Y + Sbjct: 313 VVYRDLKPANILLDEHGHVRISDLGLACDFS--KKKPHASVGTHGYMAPEVLQKGVAYDS 370 Query: 182 SIDMWSAGCIFAELANAGRPL 202 S D +S GC+ +L P Sbjct: 371 SADWFSLGCMLFKLLRGHSPF 391 >3ALO-A nrPDB Length = 327 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 68/284 (23%), Positives = 124/284 (43%), Gaps = 20/284 (7%) Query: 7 LEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRL 66 L +IG G YG+V K ++ + +I+A+KR+R D++ + +++ IV+ Sbjct: 27 LGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQF 86 Query: 67 HDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLD----PEIVKSFLFQLLKGLGFCHSR-N 121 + L + + E K++ LD EI+ +K L Sbjct: 87 YGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKENLK 146 Query: 122 VLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVL---FGAKL 178 ++HRD+KP N+L++R+G +KL DFG++ + + + Y P+ + + Sbjct: 147 IIHRDIKPSNILLDRSGNIKLCDFGISGQL-VDSIAKTRDAGCRPYMAPERIDPSASRQG 205 Query: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKP 238 Y D+WS G ELA P N V DQL ++ + G P + L + + Sbjct: 206 YDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVK--GDPPQ--------LSNSEE 255 Query: 239 YPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQ 282 P+ + VN+ + + R + LLK +P + E A++ Sbjct: 256 REFSPSFINFVNLCLTKDESKRPKYKELLK-HPFILMYEERAVE 298 >5H2U-A nrPDB Length = 267 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 55/217 (25%), Positives = 105/217 (48%), Gaps = 8/217 (3%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALR-EICLLKELKH 60 +++ K+G G +G VF+ ++ ++ +++ D + L+ EI +K+L+H Sbjct: 6 EEFTLCRKLGSGYFGEVFEGLWKDRVQVA----IKVISRDNLLHQQMLQSEIQAMKKLRH 61 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCDQD--LKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCH 118 K+I+ L+ V+ + ++ E + L+ DS L + +Q+ +G+ + Sbjct: 62 KHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLE 121 Query: 119 SRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL 178 S+N +HRDL +N+L+ N K+ DFGLAR V + + P+ L Sbjct: 122 SQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEALSRGH- 180 Query: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRI 215 YST D+WS G + E+ + G+ +PG + R+ Sbjct: 181 YSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRV 217 >5O2B-A nrPDB Length = 285 Score = 75.9 bits (185), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 70/288 (24%), Positives = 132/288 (45%), Gaps = 40/288 (13%) Query: 9 KIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHD 68 ++G G + TV+K + ET VA ++ + E +LK L+H NIVR +D Sbjct: 23 ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYD 82 Query: 69 ----VLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN--V 122 +L K + LV E K + + P++++S+ Q+LKGL F H+R + Sbjct: 83 SWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPPI 142 Query: 123 LHRDLKPQNLLINR-NGELKLADFGLARAFGIPVRCYSAEVV-TLWYRPPDVLFGAKLYS 180 +HRDLK N+ I G +K+ D GLA ++ V+ T + P++ + Y Sbjct: 143 IHRDLKCDNIFITGPTGSVKIGDLGLATLMRTS---FAKSVIGTPEFMAPEMY--EEHYD 197 Query: 181 TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYP 240 S+D+++ G E+A + P + +I+R + + + S K+ D Sbjct: 198 ESVDVYAFGMCMLEMATSEYPYSECQNA----AQIYRKVTSGIKP--ASFNKVTD----- 246 Query: 241 MYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288 P++ +++++ ++ N +R+S + L H +F++ Sbjct: 247 ------------PEV----KEIIEGCIRQNKSERLSIRDLLNHAFFAE 278 >2RIO-A nrPDB Length = 434 Score = 75.5 bits (184), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 86/310 (27%), Positives = 141/310 (45%), Gaps = 61/310 (19%) Query: 8 EKI-GEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELK-HKNIVR 65 EKI G G+ GTV + + VA+KR+ +D D AL EI LL E H N++R Sbjct: 20 EKILGYGSSGTVVFQGSFQGRP-VAVKRMLIDFCD-----IALMEIKLLTESDDHPNVIR 73 Query: 66 LHDVLHSDKKLTLVFEFCDQDLKKYFDSCN-GDLDPEIVK-----SFLFQLLKGLGFCHS 119 + +D+ L + E C+ +L+ +S N D + ++ K S L Q+ G+ HS Sbjct: 74 YYCSETTDRFLYIALELCNLNLQDLVESKNVSDENLKLQKEYNPISLLRQIASGVAHLHS 133 Query: 120 RNVLHRDLKPQNLLIN-------------RNGELKLADFGLARAFGIPVRCYSAEVV--- 163 ++HRDLKPQN+L++ N + ++DFGL + + + Sbjct: 134 LKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFRTNLNNPS 193 Query: 164 -TLWYRPPDVLFGAKLYST------SIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIF 216 T +R P++L + T SID++S GC+F + + G+ P D + I Sbjct: 194 GTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGK--HPFGDKYSRESNII 251 Query: 217 RLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRIS 276 R + + E M L D SL+ A DL+ ++ +P++R + Sbjct: 252 RGIFSLDE-----MKCLHD----------RSLI-------AEATDLISQMIDHDPLKRPT 289 Query: 277 AEEALQHPYF 286 A + L+HP F Sbjct: 290 AMKVLRHPLF 299 >4UY9-A nrPDB Length = 323 Score = 75.5 bits (184), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 65/212 (30%), Positives = 99/212 (46%), Gaps = 18/212 (8%) Query: 8 EKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLH 67 E IG G +G V++A V R D+D + +E L LKH NI+ L Sbjct: 15 EIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALR 74 Query: 68 DVLHSDKKLTLVFEFCDQD-LKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN---VL 123 V + L LV EF L + + P+I+ ++ Q+ +G+ + H ++ Sbjct: 75 GVCLKEPNLCLVMEFARGGPLNRVLSGKR--IPPDILVNWAVQIARGMNYLHDEAIVPII 132 Query: 124 HRDLKPQNLLINR---NGE-----LKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFG 175 HRDLK N+LI + NG+ LK+ DFGLAR + + +A T + P+V+ Sbjct: 133 HRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAG--TYAWMAPEVI-R 189 Query: 176 AKLYSTSIDMWSAGCIFAELANAGRPLFPGND 207 A ++S D+WS G + EL P F G D Sbjct: 190 ASMFSKGSDVWSYGVLLWELLTGEVP-FRGID 220 >3DTC-A nrPDB Length = 271 Score = 75.5 bits (184), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 65/212 (30%), Positives = 96/212 (45%), Gaps = 18/212 (8%) Query: 8 EKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLH 67 E IG G +G V++A V R D+D + +E L LKH NI+ L Sbjct: 13 EIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALR 72 Query: 68 DVLHSDKKLTLVFEFCDQD-LKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN---VL 123 V + L LV EF L + + P+I+ ++ Q+ +G+ + H ++ Sbjct: 73 GVCLKEPNLCLVMEFARGGPLNRVLSGKR--IPPDILVNWAVQIARGMNYLHDEAIVPII 130 Query: 124 HRDLKPQNLLINR---NGE-----LKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFG 175 HRDLK N+LI + NG+ LK+ DFGLAR + + SA W P + Sbjct: 131 HRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTK-MSAAGAYAWMAPE--VIR 187 Query: 176 AKLYSTSIDMWSAGCIFAELANAGRPLFPGND 207 A ++S D+WS G + EL P F G D Sbjct: 188 ASMFSKGSDVWSYGVLLWELLTGEVP-FRGID 218 >4PL5-B nrPDB Length = 435 Score = 75.5 bits (184), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 80/294 (27%), Positives = 129/294 (43%), Gaps = 55/294 (18%) Query: 10 IGEGTYGT-VFKA--KNRETHEIVALKRVRLDDDDEGVPSSALREICLLKEL-KHKNIVR 65 +G G GT V+K NR+ VA+KR+ + S A RE+ LL+E +H N++R Sbjct: 35 LGHGAEGTIVYKGMFDNRD----VAVKRILPE-----CFSFADREVQLLRESDEHPNVIR 85 Query: 66 LHDVLHSDKKLTLVFEFCDQDLKKYF---DSCNGDLDPEIVKSFLFQLLKGLGFCHSRNV 122 + + E C L++Y D + L+P + L Q GL HS N+ Sbjct: 86 YFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEP---ITLLHQTTSGLAHLHSLNI 142 Query: 123 LHRDLKPQNLLI---NRNGELK--LADFGLARAFGIPVRCYSAEV----VTLWYRPPDVL 173 +HRDLKP N+L+ N +G +K ++DFGL + + +S W P + Sbjct: 143 VHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLS 202 Query: 174 FGAKLYST-SIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTK 232 K T ++D++SAGC+F + + G F G + Q LLG Sbjct: 203 EDCKDNPTYTVDIFSAGCVFYYVISEGYHPF-GKSLQRQAN---ILLGA----------- 247 Query: 233 LPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286 + + R+L++ ++ +P QR SA+ L+HP+F Sbjct: 248 -----------CNLDCFHSDKHEDVIARELIEKMIAMDPQQRPSAKHVLKHPFF 290 >6FYV-A nrPDB Length = 337 Score = 75.1 bits (183), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 86/330 (26%), Positives = 144/330 (43%), Gaps = 58/330 (17%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEI-VALKRVRLDDDDEGVPSSALR-EICLLKELKH 60 +YE ++ +GEG +G V + + + VA+K V+ + G A R EI +L+ L Sbjct: 15 RYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVK----NVGRYREAARSEIQVLEHLNS 70 Query: 61 KN------IVRLHDVLHSDKKLTLVFEFCDQDLKKY-FDSCNGDLDPEI--VKSFLFQLL 111 + V++ + + +VFE L Y F N L +I ++ +Q+ Sbjct: 71 TDPNSVFRCVQMLEWFDHHGHVCIVFELLG--LSTYDFIKENSFLPFQIDHIRQMAYQIC 128 Query: 112 KGLGFCHSRNVLHRDLKPQNLLIN-------------------RNGELKLADFGLARAFG 152 + + F H + H DLKP+N+L +N ++K+ DFG A Sbjct: 129 QSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSA---T 185 Query: 153 IPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQL 212 +S V T YR P+V+ A +S D+WS GCI E G +F +D + L Sbjct: 186 YDDEHHSTLVSTRHYRAPEVIL-ALGWSQPCDVWSIGCILIEYY-LGFTVFQTHDSKEHL 243 Query: 213 KRIFRLLGTPTEEQWPSMTKLPDYKPYPM--YPATTSLVNVVPKL--------------N 256 + R+LG P + T+ Y + + +S V + + Sbjct: 244 AMMERILG-PIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEH 302 Query: 257 ATGRDLLQNLLKCNPVQRISAEEALQHPYF 286 DL++ +L+ +P QRI+ +EALQHP+F Sbjct: 303 EKLFDLVRRMLEYDPTQRITLDEALQHPFF 332 >5O2C-A nrPDB Length = 380 Score = 75.1 bits (183), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 70/288 (24%), Positives = 128/288 (44%), Gaps = 40/288 (13%) Query: 9 KIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHD 68 ++G G + TV+K + ET VA ++ + E +LK L+H NIVR +D Sbjct: 32 ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYD 91 Query: 69 ----VLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN--V 122 +L K + LV E K + + P++++S+ Q+LKGL F H+R + Sbjct: 92 SWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPPI 151 Query: 123 LHRDLKPQNLLINR-NGELKLADFGLARAFGIPVRCYSAEVV-TLWYRPPDVLFGAKLYS 180 +HRDLK N+ I G +K+ D GLA ++ V+ T + P++ + Y Sbjct: 152 IHRDLKCDNIFITGPTGSVKIGDLGLATLMRT---SFAKSVIGTPEFMAPEMY--EEHYD 206 Query: 181 TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYP 240 S+D+++ G E+A + P + +I+R + + KP Sbjct: 207 ESVDVYAFGMCMLEMATSEYPYSECQNA----AQIYRKVTS-------------GIKPAS 249 Query: 241 MYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288 T V +++++ ++ N +R+S + L H +F++ Sbjct: 250 FNKVTDPEV----------KEIIEGCIRQNKSERLSIRDLLNHAFFAE 287 >5AMN-A nrPDB Length = 299 Score = 75.1 bits (183), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 62/234 (26%), Positives = 108/234 (46%), Gaps = 33/234 (14%) Query: 10 IGEGTYGTVFKA-----KNRETHEIVALKRVRLDDDDEGVPSSALR----EICLLKELKH 60 +GEG +G V KA K R + VA+K ++ E S LR E +LK++ H Sbjct: 31 LGEGEFGKVVKATAFHLKGRAGYTTVAVKMLK-----ENASPSELRDLLSEFNVLKQVNH 85 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEI----------VKSFLFQL 110 ++++L+ D L L+ E+ + F + + P + SF +Q+ Sbjct: 86 PHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYPDERALTMGDLISFAWQI 145 Query: 111 LKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAF---GIPVRCYSAEVVTLWY 167 +G+ + ++HRDL +N+L+ ++K++DFGL+R V+ + W Sbjct: 146 SQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWM 205 Query: 168 RPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGT 221 + LF +Y+T D+WS G + E+ G +PG + R+F LL T Sbjct: 206 -AIESLFD-HIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPE----RLFNLLKT 253 >3OMV-A nrPDB Length = 307 Score = 74.7 bits (182), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 58/228 (25%), Positives = 107/228 (46%), Gaps = 27/228 (11%) Query: 9 KIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHD 68 +IG G++GTV+K K H VA+K +++ D + E+ +L++ +H NI+ Sbjct: 43 RIGSGSFGTVYKGK---WHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMG 99 Query: 69 VLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLL-------KGLGFCHSRN 121 + D L +V ++C+ S L + K +FQL+ +G+ + H++N Sbjct: 100 YMTKDN-LAIVTQWCEGS------SLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKN 152 Query: 122 VLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVV------TLWYRPPDV-LF 174 ++HRD+K N+ ++ +K+ DFGLA + R ++ V LW P + + Sbjct: 153 IIHRDMKSNNIFLHEGLTVKIGDFGLAT---VKSRWSGSQQVEQPTGSVLWMAPEVIRMQ 209 Query: 175 GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTP 222 +S D++S G + EL P N+ D + + R +P Sbjct: 210 DNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASP 257 >4TPT-A nrPDB Length = 303 Score = 74.7 bits (182), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 53/209 (25%), Positives = 101/209 (48%), Gaps = 25/209 (11%) Query: 8 EKIGEGTYGTVFKAKNRETHEIVALKR-VRLDDDDEGVPSSALREICLLKELKHKNIVRL 66 E +G+G +G K ++ T +++ +K +R D++ + + L E+ +++ L H N+++ Sbjct: 6 EVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQ---KTFLTEVKVMRSLDHPNVLKF 62 Query: 67 HDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRD 126 VL+ DKKL L+ E+ + K F + F + G+ + HS ++HRD Sbjct: 63 IGVLYKDKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMAYLHSMCIIHRD 122 Query: 127 LKPQNLLINRNGELKLADFGLARAF-----GIPVRCYSAEVVTL---------------W 166 L N LI + + +ADFGL+R P+ + + TL + Sbjct: 123 LNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGNPY 182 Query: 167 YRPPDVLFGAKLYSTSIDMWSAGCIFAEL 195 + P++L G K Y ++D++S G + E+ Sbjct: 183 WMAPEMLNG-KSYDETVDIFSFGIVLCEI 210 >6GQK-A nrPDB Length = 328 Score = 74.7 bits (182), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 78/296 (26%), Positives = 120/296 (40%), Gaps = 61/296 (20%) Query: 10 IGEGTYGTVFKAKNR-----ETHEIVALKRVRLDDDDEGVPS--SALREICLLKELK--- 59 +G G +G V +A + + VA+K ++ PS S RE L+ ELK Sbjct: 49 LGAGAFGKVVEATAQGLIKSDAAMTVAVKMLK--------PSAHSTERE-ALMSELKVLS 99 Query: 60 ----HKNIVRLHDV-LHSDKKLTLVFEFCDQDLKKYFDSCNGDLDP-------------- 100 H+NIV L H L + C DL + + P Sbjct: 100 YLGNHENIVNLLGACTHGGPTLVITEYCCYGDLLNFLRRKRDEFVPYKVAPEDLYKDFLT 159 Query: 101 -EIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAF---GIPVR 156 E + SF +Q+ KG+ F S+N +HRDL +N+L+ K+ DFGLAR V Sbjct: 160 LEHLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGNITKICDFGLARDIKNDSNYVD 219 Query: 157 CYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQ----L 212 +A + W P + +Y+ D+WS G EL + G +PG VD + + Sbjct: 220 KGNARLPVKWMAPESIF--NSVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMI 277 Query: 213 KRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLK 268 K FR+ P+Y P MY + + P T + ++Q++ K Sbjct: 278 KEGFRMSS-------------PEYAPAEMYDIMKTCWDADPDKRPTFKQIVQDIEK 320 >6HV0-A nrPDB Length = 416 Score = 74.7 bits (182), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 77/291 (26%), Positives = 131/291 (45%), Gaps = 49/291 (16%) Query: 10 IGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKEL-KHKNIVRLHD 68 +G G GT+ + + VA+KR+ + S A RE+ LL+E +H N++R Sbjct: 16 LGHGAEGTIVYRGMFDNRD-VAVKRILPE-----CFSFADREVQLLRESDEHPNVIRYFC 69 Query: 69 VLHSDKKLTLVFEFCDQDLKKYF---DSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHR 125 + + E C L++Y D + L+P + L Q GL HS N++HR Sbjct: 70 TEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEP---ITLLQQTTSGLAHLHSLNIVHR 126 Query: 126 DLKPQNLLI---NRNGELK--LADFGLARAFGIPVRCYSAEV----VTLWYRPPDVLFGA 176 DLKP N+LI N +G++K ++DFGL + + +S W P + Sbjct: 127 DLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDC 186 Query: 177 KLYST-SIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPD 235 K T ++D++SAGC+F + + G F G + Q LLG + + Sbjct: 187 KENPTYTVDIFSAGCVFYYVISEGSHPF-GKSLQRQAN---ILLGACSLD---------- 232 Query: 236 YKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286 ++P + R+L++ ++ +P +R SA+ L+HP+F Sbjct: 233 ----CLHPEKHE--------DVIARELIEKMIAMDPQKRPSAKHVLKHPFF 271 >2I0E-A nrPDB Length = 353 Score = 74.3 bits (181), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 56/214 (26%), Positives = 107/214 (50%), Gaps = 16/214 (7%) Query: 10 IGEGTYGTVFKAKNRETHEIVALKRVRLD----DDDEGVPSSALREICLLKELKHKNIVR 65 +G+G++G V ++ + T E+ A+K ++ D DDD V + + + L K + + Sbjct: 28 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDD--VECTMVEKRVLALPGKPPFLTQ 85 Query: 66 LHDVLHSDKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLH 124 LH + +L V E+ + DL + +P V + ++ GL F S+ +++ Sbjct: 86 LHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAV-FYAAEIAIGLFFLQSKGIIY 144 Query: 125 RDLKPQNLLINRNGELKLADFGLARAF---GIPVRCYSAEVVTLWYRPPDVLFGAKLYST 181 RDLK N++++ G +K+ADFG+ + G+ + + T Y P+++ + Y Sbjct: 145 RDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCG---TPDYIAPEII-AYQPYGK 200 Query: 182 SIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRI 215 S+D W+ G + E+ AG+ F G D D+ + I Sbjct: 201 SVDWWAFGVLLYEML-AGQAPFEGEDEDELFQSI 233 >2X7G-A nrPDB Length = 389 Score = 74.3 bits (181), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 89/364 (24%), Positives = 146/364 (40%), Gaps = 86/364 (23%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62 +Y + K+G G + TV+ + + VA+K V+ + +AL EI LLK ++ + Sbjct: 32 RYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVK---SAQHYTETALDEIKLLKCVRESD 88 Query: 63 --------IVRLHDVLH----SDKKLTLVFEFCDQDLKKYFDSCN-GDLDPEIVKSFLFQ 109 +V+L D + + +VFE L K+ N L VKS + Q Sbjct: 89 PSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQ 148 Query: 110 LLKGLGFCHSR-NVLHRDLKPQN------------------------------------- 131 +L+GL + HS+ ++H D+KP+N Sbjct: 149 VLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAVSTAP 208 Query: 132 ---LLIN----RNGE---LKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYST 181 LL+N RN + +K+AD G A + ++ ++ T YR +VL GA YST Sbjct: 209 AADLLVNPLDPRNADKIRVKIADLGNACWVH---KHFTEDIQTRQYRSIEVLIGAG-YST 264 Query: 182 SIDMWSAGCIFAELANAGRPLFPGNDVD-----DQLKRIFRLLGTPTEE----------- 225 D+WS C+ ELA P + D D + I LLG+ Sbjct: 265 PADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREF 324 Query: 226 --QWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQH 283 + + + KP+ ++ + A D L +L+ P +R SA E L+H Sbjct: 325 FNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRH 384 Query: 284 PYFS 287 P+ + Sbjct: 385 PWLN 388 >3KN6-A nrPDB Length = 325 Score = 73.9 bits (180), Expect = 8e-14, Method: Compositional matrix adjust. Identities = 60/205 (29%), Positives = 96/205 (46%), Gaps = 26/205 (12%) Query: 10 IGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELK-HKNIVRLHD 68 +GEG++ K ++++++ A+K + + + ++ +EI LK + H NIV+LH+ Sbjct: 19 LGEGSFSICRKCVHKKSNQAFAVKII-----SKRMEANTQKEITALKLCEGHPNIVKLHE 73 Query: 69 VLHSDKKLTLVFEFCDQ-------DLKKYFDSCNGDLDPEIVKSFLF-QLLKGLGFCHSR 120 V H LV E + KK+F E S++ +L+ + H Sbjct: 74 VFHDQLHTFLVMELLNGGELFERIKKKKHFS--------ETEASYIMRKLVSAVSHMHDV 125 Query: 121 NVLHRDLKPQNLLI---NRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAK 177 V+HRDLKP+NLL N N E+K+ DFG AR + TL Y P++L Sbjct: 126 GVVHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELL-NQN 184 Query: 178 LYSTSIDMWSAGCIFAELANAGRPL 202 Y S D+WS G I + + P Sbjct: 185 GYDESCDLWSLGVILYTMLSGQVPF 209 >3MV5-A nrPDB Length = 342 Score = 73.9 bits (180), Expect = 8e-14, Method: Compositional matrix adjust. Identities = 71/299 (23%), Positives = 135/299 (45%), Gaps = 48/299 (16%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLD---DDDEGVPSSALREICLLKE 57 M ++E L+ +G+GT+G V K + T A+K ++ + DE + L E +L+ Sbjct: 9 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDE--VAHTLTENRVLQN 66 Query: 58 LKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFC 117 +H + L + +L V E+ + + S + + + +++ L + Sbjct: 67 SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYL 126 Query: 118 HS-RNVLHRDLKPQNLLINRNGELKLADFGLARAF---GIPVRCYSAEVVTLWYRPPDVL 173 HS +NV++RDLK +NL+++++G +K+ DFGL + G ++ + T Y P+VL Sbjct: 127 HSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCG---TPEYLAPEVL 183 Query: 174 FGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKL 233 Y ++D W G + E+ P + + +++F L+ M ++ Sbjct: 184 EDND-YGRAVDWWGLGVVMYEMMCGRLPFY-----NQDHEKLFELI---------LMEEI 228 Query: 234 PDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRIS-----AEEALQHPYFS 287 +P T L + LL LLK +P QR+ A+E +QH +F+ Sbjct: 229 -------RFPRT---------LGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFA 271 >3PFQ-A nrPDB Length = 674 Score = 73.9 bits (180), Expect = 8e-14, Method: Compositional matrix adjust. Identities = 56/214 (26%), Positives = 107/214 (50%), Gaps = 16/214 (7%) Query: 10 IGEGTYGTVFKAKNRETHEIVALKRVRLD----DDDEGVPSSALREICLLKELKHKNIVR 65 +G+G++G V ++ + T E+ A+K ++ D DDD V + + + L K + + Sbjct: 349 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDD--VECTMVEKRVLALPGKPPFLTQ 406 Query: 66 LHDVLHSDKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLH 124 LH + +L V E+ + DL + +P V + ++ GL F S+ +++ Sbjct: 407 LHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAV-FYAAEIAIGLFFLQSKGIIY 465 Query: 125 RDLKPQNLLINRNGELKLADFGLARAF---GIPVRCYSAEVVTLWYRPPDVLFGAKLYST 181 RDLK N++++ G +K+ADFG+ + G+ + + T Y P+++ + Y Sbjct: 466 RDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCG---TPDYIAPEII-AYQPYGK 521 Query: 182 SIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRI 215 S+D W+ G + E+ AG+ F G D D+ + I Sbjct: 522 SVDWWAFGVLLYEML-AGQAPFEGEDEDELFQSI 554 >4PDO-A nrPDB Length = 299 Score = 73.6 bits (179), Expect = 9e-14, Method: Compositional matrix adjust. Identities = 61/232 (26%), Positives = 111/232 (47%), Gaps = 18/232 (7%) Query: 10 IGEGTYGTVFKAKNRETH---EI-VALKRVRLDDDDEGVPSSALREICLLKELKHKNIVR 65 IG G +G V+K + + E+ VA+K ++ E L E ++ + H NI+R Sbjct: 42 IGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYT-EKQRVDFLGEAGIMGQFSHHNIIR 100 Query: 66 LHDVLHSDKKLTLVFEFCDQD-LKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLH 124 L V+ K + ++ E+ + L K+ +G+ + L + G+ + + N +H Sbjct: 101 LEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAGMKYLANMNYVH 160 Query: 125 RDLKPQNLLINRNGELKLADFGLARAF-GIPVRCYS---AEVVTLWYRPPDVLFGAKLYS 180 RDL +N+L+N N K++DFGL+R P Y+ ++ W P + + + ++ Sbjct: 161 RDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISY--RKFT 218 Query: 181 TSIDMWSAGCIFAELANAG-RPLF--PGNDVDDQLKRIFRLLGTPTEEQWPS 229 ++ D+WS G + E+ G RP + ++V + FRL PT PS Sbjct: 219 SASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRL---PTPMDCPS 267 >4AT3-A nrPDB Length = 299 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 75/290 (25%), Positives = 132/290 (45%), Gaps = 42/290 (14%) Query: 9 KIGEGTYGTVFKAKN-----RETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 ++GEG +G VF A+ + +VA+K L D + RE LL L+H++I Sbjct: 20 ELGEGAFGKVFLAECYNLCPEQDKILVAVKT--LKDASDNARKDFHREAELLTNLQHEHI 77 Query: 64 VRLHDVLHSDKKLTLVFEFCDQ-DLKKYFDS--------CNGDLDPEIVKSFLF----QL 110 V+ + V L +VFE+ DL K+ + G+ E+ +S + Q+ Sbjct: 78 VKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQI 137 Query: 111 LKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIP--VRCYSAEVVTLWYR 168 G+ + S++ +HRDL +N L+ N +K+ DFG++R R ++ + + Sbjct: 138 AAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWM 197 Query: 169 PPDVLFGAKLYSTSIDMWSAGCIFAELANAGR-PLF--PGNDVDDQLK--RIFRLLGTPT 223 PP+ + K ++T D+WS G + E+ G+ P + N+V + + R+ + T Sbjct: 198 PPESIMYRK-FTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCP 256 Query: 224 EEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATG-RDLLQNLLKCNPV 272 +E + M +P+ + N G LLQNL K +PV Sbjct: 257 QEVYELMLGCWQREPH-------------MRKNIKGIHTLLQNLAKASPV 293 >5O0Y-A nrPDB Length = 579 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 65/237 (27%), Positives = 105/237 (44%), Gaps = 27/237 (11%) Query: 15 YGTVFKAKNRETHEIVALKRVRL-----DDDDEGVPSSALREICLLKELKHKNIVRLHDV 69 + V+KA + VA+K +L D+ E A RE + KEL H IV+L+D Sbjct: 297 FSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDY 356 Query: 70 LHSDK-KLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN--VLHRD 126 D V E+C+ + ++ + + + +S + Q++ L + + ++H D Sbjct: 357 FSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYD 416 Query: 127 LKPQN-LLINRN--GELKLADFGLARAF---------GIPVRCYSAEVVTLWYRPPDVLF 174 LKP N LL+N GE+K+ DFGL++ G+ + A T WY PP+ Sbjct: 417 LKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGA--GTYWYLPPECFV 474 Query: 175 GAK---LYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWP 228 K S +D+WS G IF + +P D L+ + TE Q+P Sbjct: 475 VGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQE--NTILKATEVQFP 529 >3ZZW-A nrPDB Length = 289 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 60/240 (25%), Positives = 107/240 (44%), Gaps = 41/240 (17%) Query: 7 LEKIGEGTYGTVFKAK-----NRETHEIVALKRVRLDDDDEGVPSSALREICLLK-ELKH 60 +E++GE +G V+K E + VA+K L D EG R +L+ L+H Sbjct: 14 MEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKT--LKDKAEGPLREEFRHEAMLRARLQH 71 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCDQ-DLKKYF---------------DSCNGDLDPEIVK 104 N+V L V+ D+ L+++F +C DL ++ + L+P Sbjct: 72 PNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFV 131 Query: 105 SFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVT 164 + Q+ G+ + S +V+H+DL +N+L+ +K++D GL R Y+A+ Sbjct: 132 HLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFR------EVYAADYYK 185 Query: 165 L---------WYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRI 215 L W P +++G +S D+WS G + E+ + G + G D ++ I Sbjct: 186 LLGNSLLPIRWMAPEAIMYGK--FSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMI 243 >5KCV-A nrPDB Length = 460 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 71/299 (23%), Positives = 135/299 (45%), Gaps = 48/299 (16%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLD---DDDEGVPSSALREICLLKE 57 M ++E L+ +G+GT+G V K + T A+K ++ + DE + L E +L+ Sbjct: 161 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDE--VAHTLTENRVLQN 218 Query: 58 LKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFC 117 +H + L + +L V E+ + + S + + + +++ L + Sbjct: 219 SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYL 278 Query: 118 HS-RNVLHRDLKPQNLLINRNGELKLADFGLARAF---GIPVRCYSAEVVTLWYRPPDVL 173 HS +NV++RDLK +NL+++++G +K+ DFGL + G ++ + T Y P+VL Sbjct: 279 HSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCG---TPEYLAPEVL 335 Query: 174 FGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKL 233 Y ++D W G + E+ P + + +++F L+ M ++ Sbjct: 336 EDND-YGRAVDWWGLGVVMYEMMCGRLPFY-----NQDHEKLFELI---------LMEEI 380 Query: 234 PDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRIS-----AEEALQHPYFS 287 +P T L + LL LLK +P QR+ A+E +QH +F+ Sbjct: 381 -------RFPRT---------LGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFA 423 >2JD5-A nrPDB Length = 373 Score = 73.2 bits (178), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 88/335 (26%), Positives = 140/335 (41%), Gaps = 64/335 (19%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLK------ 56 +Y + K+G G + TV+ AK+ + VA+K VR D+ +A EI LL+ Sbjct: 20 RYILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVR---GDKVYTEAAEDEIKLLQRVNDAD 76 Query: 57 -----ELKHKNIVRLHDVLHSDKK------LTLVFEFCDQDLKKYFDSCNGDLDPEI-VK 104 + +I++L D H + K + +VFE ++L P I VK Sbjct: 77 NTKEDSMGANHILKLLD--HFNHKGPNGVHVVMVFEVLGENLLALIKKYEHRGIPLIYVK 134 Query: 105 SFLFQLLKGLGFCHSR-NVLHRDLKPQNLLINRNG------ELKLADFGLARAFGIPVRC 157 QLL GL + H R ++H D+KP+N+L+ ++K+AD G A + Sbjct: 135 QISKQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNACWYD---EH 191 Query: 158 YSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDV------DDQ 211 Y+ + T YR P+VL GA + D+WS C+ EL G LF ++ DD Sbjct: 192 YTNSIQTREYRSPEVLLGAP-WGCGADIWSTACLIFELI-TGDFLFEPDEGHSYTKDDDH 249 Query: 212 LKRIFRLLGTPTEEQWPS------------------MTKLPDYKPYPMYPATTSLVNVVP 253 + +I LLG + PS + + K +P+ T Sbjct: 250 IAQIIELLG-----ELPSYLLRNGKYTRTFFNSRGLLRNISKLKFWPLEDVLTEKYKFSK 304 Query: 254 KLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288 D L +L+ +P +R A + HP+ D Sbjct: 305 DEAKEISDFLSPMLQLDPRKRADAGGLVNHPWLKD 339 >3QGY-A nrPDB Length = 286 Score = 72.8 bits (177), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 56/221 (25%), Positives = 102/221 (46%), Gaps = 18/221 (8%) Query: 7 LEKIGEGTYGTVFKAK--NRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIV 64 +++IG G +G V N++ I +K + +DD + E ++ +L H +V Sbjct: 32 VQEIGSGQFGLVHLGYWLNKDKVAIKTIKEGSMSEDD------FIEEAEVMMKLSHPKLV 85 Query: 65 RLHDVLHSDKKLTLVFEFCDQD-LKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVL 123 +L+ V + LVFEF + L Y + G E + + +G+ + V+ Sbjct: 86 QLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVI 145 Query: 124 HRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTL---WYRPPDVLFGAKLYS 180 HRDL +N L+ N +K++DFG+ R F + + S+ W P +F YS Sbjct: 146 HRDLAARNCLVGENQVIKVSDFGMTR-FVLDDQYTSSTGTKFPVKWASPE--VFSFSRYS 202 Query: 181 TSIDMWSAGCIFAELANAGRPLF---PGNDVDDQLKRIFRL 218 + D+WS G + E+ + G+ + ++V + + FRL Sbjct: 203 SKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRL 243 >6ED6-A nrPDB Length = 415 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 72/296 (24%), Positives = 128/296 (43%), Gaps = 38/296 (12%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRV-RLDDDDEGVPSSALREICLLKELKH 60 + Y+ ++ IG G +G V +++ + ++ A+K + + + + E ++ Sbjct: 88 EDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANS 147 Query: 61 KNIVRLHDVLHSDKKLTLVFEFC-DQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 +V+L D+ L +V E+ DL N D+ + K + +++ L HS Sbjct: 148 PWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLM--SNYDVPEKWAKFYTAEVVLALDAIHS 205 Query: 120 RNVLHRDLKPQNLLINRNGELKLADFGLARAFGIP--VRCYSAEVVTLWYRPPDVL---F 174 ++HRD+KP N+L++++G LKLADFG V C +A V T Y P+VL Sbjct: 206 MGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTA-VGTPDYISPEVLKSQG 264 Query: 175 GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLP 234 G Y D WS G E+ P + + L+GT +K+ Sbjct: 265 GDGFYGRECDWWSVGVFLYEMLVGDTPFYADS-----------LVGT--------YSKIM 305 Query: 235 DYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQ--RISAEEALQHPYFSD 288 D+K +P +++ ++L+ L V+ R EE QHP+F + Sbjct: 306 DHKNSLCFPEDA-------EISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKN 354 >5LOH-A nrPDB Length = 341 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 70/299 (23%), Positives = 129/299 (43%), Gaps = 45/299 (15%) Query: 1 MQKYEKLEKIGEGTYGTVF-KAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELK 59 ++++ ++ I G +G V+ K + + + +K+ + + + A R+ L K Sbjct: 35 IEEFSIVKPISRGAFGKVYLGQKGGKLYAVKVVKKADMINKNMTHQVQAERDALALS--K 92 Query: 60 HKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 IV L+ L S + LV E+ K G D E+ ++ ++ L + H Sbjct: 93 SPFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALALDYLHR 152 Query: 120 RNVLHRDLKPQNLLINRNGELKLADFGLARAF---------GIPVRCYSAEVVTLWYRPP 170 ++HRDLKP N+LI+ G +KL DFGL++ + R + T Y P Sbjct: 153 HGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILTTRTFCG---TPDYLAP 209 Query: 171 DVLFGAKLYSTSIDMWSAG-CIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPS 229 ++L G + + ++D W+ G C+F L G P F D+ +++F+ + + WP Sbjct: 210 ELLLG-RAHGPAVDWWALGVCLFEFL--TGIPPFN----DETPQQVFQNI-LKRDIPWPE 261 Query: 230 MTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288 + KL+ + ++ LL + +R +E +HP FSD Sbjct: 262 GEE---------------------KLSDNAQSAVEILLTIDDTKRAGMKELKRHPLFSD 299 >4TNB-A nrPDB Length = 590 Score = 72.4 bits (176), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 57/198 (28%), Positives = 95/198 (47%), Gaps = 9/198 (4%) Query: 10 IGEGTYGTVFKAKNRETHEIVALKRVRLDD-DDEGVPSSALREICLLKELKHKNIVRLHD 68 +G+G +G V + R T ++ A KR+ S AL E +L+++ + +V L Sbjct: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAY 251 Query: 69 VLHSDKKLTLVFEFCDQ-DLKKY-FDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRD 126 + L LV + DLK + ++ N + E + ++L GL H N ++RD Sbjct: 252 AYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHHENTVYRD 311 Query: 127 LKPQNLLINRNGELKLADFGLARAF--GIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSID 184 LKP+N+L++ G ++++D GLA G +R V T+ Y P+VL + Y S D Sbjct: 312 LKPENILLDDYGHIRISDLGLAVKIPEGDLIR---GRVGTVGYMAPEVLNNQR-YGLSPD 367 Query: 185 MWSAGCIFAELANAGRPL 202 W GC+ E+ P Sbjct: 368 YWGLGCLIYEMIEGQSPF 385 >4OLI-A nrPDB Length = 645 Score = 72.4 bits (176), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 59/202 (29%), Positives = 101/202 (50%), Gaps = 16/202 (7%) Query: 5 EKLEKIGEGTYGTV----FKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 +K+ +GEG +G V + N T E+VA+K ++ D + S +EI +L+ L H Sbjct: 356 KKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHR-SGWKQEIDILRTLYH 414 Query: 61 KNIVRLHDVL--HSDKKLTLVFEFCD-QDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFC 117 ++I++ +K L LV E+ L+ Y + L ++ F Q+ +G+ + Sbjct: 415 EHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLL--FAQQICEGMAYL 472 Query: 118 HSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCY----SAEVVTLWYRPPDVL 173 HS++ +HR+L +N+L++ + +K+ DFGLA+A Y + WY P+ L Sbjct: 473 HSQHYIHRNLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWY-APECL 531 Query: 174 FGAKLYSTSIDMWSAGCIFAEL 195 K Y S D+WS G EL Sbjct: 532 KEYKFYYAS-DVWSFGVTLYEL 552 >3VHK-A nrPDB Length = 368 Score = 72.0 bits (175), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 52/174 (29%), Positives = 83/174 (47%), Gaps = 17/174 (9%) Query: 106 FLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLAR-AFGIP--VRCYSAEV 162 + FQ+ KG+ F SR +HRDL +N+L++ +K+ DFGLAR + P VR A + Sbjct: 205 YSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARL 264 Query: 163 VTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTP 222 W P + ++Y+ D+WS G + E+ + G +PG +D++ R + GT Sbjct: 265 PLKWMAPETIF--DRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLK-EGT- 320 Query: 223 TEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQ---NLLKCNPVQ 273 + PDY MY + P T +L++ NLL+ N Q Sbjct: 321 -------RMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQ 367 >6E9W-A nrPDB Length = 443 Score = 72.0 bits (175), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 57/209 (27%), Positives = 96/209 (45%), Gaps = 10/209 (4%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRV-RLDDDDEGVPSSALREICLLKELKH 60 + YE ++ IG G +G V +++ T ++ A+K + + + + E ++ Sbjct: 102 EDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANS 161 Query: 61 KNIVRLHDVLHSDKKLTLVFEFC-DQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 +V+L D+ L +V E+ DL N D+ + + + +++ L HS Sbjct: 162 PWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLM--SNYDVPEKWARFYTAEVVLALDAIHS 219 Query: 120 RNVLHRDLKPQNLLINRNGELKLADFGLARAFGIP--VRCYSAEVVTLWYRPPDVL---F 174 +HRD+KP N+L++++G LKLADFG VRC +A V T Y P+VL Sbjct: 220 MGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTA-VGTPDYISPEVLKSQG 278 Query: 175 GAKLYSTSIDMWSAGCIFAELANAGRPLF 203 G Y D WS G E+ P + Sbjct: 279 GDGYYGRECDWWSVGVFLYEMLVGDTPFY 307 >2PMN-X nrPDB Length = 348 Score = 72.0 bits (175), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 58/250 (23%), Positives = 118/250 (47%), Gaps = 26/250 (10%) Query: 51 EICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDP--------EI 102 E+ ++ ++K++ + ++ + ++ +++E+ + D FD LD ++ Sbjct: 93 ELQIITDIKNEYCLTCEGIITNYDEVYIIYEYMENDSILKFDEYFFVLDKNYTCFIPIQV 152 Query: 103 VKSFLFQLLKGLGFCHS-RNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAE 161 +K + +L + H+ +N+ HRD+KP N+L+++NG +KL+DFG + + + Sbjct: 153 IKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMDKNGRVKLSDFGESEY--MVDKKIKGS 210 Query: 162 VVTLWYRPPDVLFGAKLYS-TSIDMWSAG-CIFAELANAGRPLFPGNDVDDQLKRIFRLL 219 T + PP+ Y+ +D+WS G C++ N P + L +F + Sbjct: 211 RGTYEFMPPEFFSNESSYNGAKVDIWSLGICLYVMFYNVV-PF----SLKISLVELFNNI 265 Query: 220 GTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPK-LNATGRDLLQNLLKCNPVQRISAE 278 T E P + + +YP T L+ D L+ L+ NP +RI++E Sbjct: 266 RTKNIE-------YPLDRNHFLYPLTNKKSTCSNNFLSNEDIDFLKLFLRKNPAERITSE 318 Query: 279 EALQHPYFSD 288 +AL+H + +D Sbjct: 319 DALKHEWLAD 328 >5N23-A nrPDB Length = 352 Score = 72.0 bits (175), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 52/208 (25%), Positives = 103/208 (49%), Gaps = 12/208 (5%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVP----SSALREICLLK 56 + ++E++ +G G++G V K++ET A+K + D + V L E + + Sbjct: 41 LDQFERIRTLGTGSFGRVMLVKHKETGNHYAMK---ILDKQKVVKLKQIEHTLNEKRIQQ 97 Query: 57 ELKHKNIVRLHDVLHSDKKLTLVFEFC-DQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLG 115 + +V+L + L +V E+ ++ + +P + + Q++ Sbjct: 98 AVNFPFLVKLEFSFKDNSNLYMVLEYAPGGEMFSHLRRIGRFSEPH-ARFYAAQIVLTFE 156 Query: 116 FCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFG 175 + HS ++++RDLKP+NLLI++ G +K+ADFG A+ + R T Y P+++ Sbjct: 157 YLHSLDLIYRDLKPENLLIDQQGYIKVADFGFAKR--VKGRTPWTLCGTPEYLAPEIIL- 213 Query: 176 AKLYSTSIDMWSAGCIFAELANAGRPLF 203 +K Y+ ++D W+ G + E+A P F Sbjct: 214 SKGYNKAVDWWALGVLIYEMAAGYPPFF 241 >4HVI-A nrPDB Length = 314 Score = 71.6 bits (174), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 54/200 (27%), Positives = 93/200 (46%), Gaps = 15/200 (7%) Query: 7 LEKIGEGTYGTV----FKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62 + ++G+G +G+V + T +VA+K+++ D+ REI +LK L Sbjct: 15 ISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQ--QRDFQREIQILKALHSDF 72 Query: 63 IVRLHDVLHS--DKKLTLVFEFCDQD-LKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 IV+ V + + L LV E+ L+ + LD + + Q+ KG+ + S Sbjct: 73 IVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGS 132 Query: 120 RNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCY----SAEVVTLWYRPPDVLFG 175 R +HRDL +N+L+ +K+ADFGLA+ + Y + WY P + Sbjct: 133 RRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESL--S 190 Query: 176 AKLYSTSIDMWSAGCIFAEL 195 ++S D+WS G + EL Sbjct: 191 DNIFSRQSDVWSFGVVLYEL 210 >4EBW-A nrPDB Length = 304 Score = 71.6 bits (174), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 52/212 (24%), Positives = 99/212 (46%), Gaps = 10/212 (4%) Query: 10 IGEGTYGTVFKAKNRETHE---IVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRL 66 IGEG +G V + VA+K + + + V L+E +++ H +IV+L Sbjct: 46 IGEGQFGDVHQGIYMSPENPALAVAIKTCK-NCTSDSVREKFLQEALTMRQFDHPHIVKL 104 Query: 67 HDVLHSDKKLTLVFEFCD-QDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHR 125 V+ ++ + ++ E C +L+ + LD + + +QL L + S+ +HR Sbjct: 105 IGVI-TENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHR 163 Query: 126 DLKPQNLLINRNGELKLADFGLARAF--GIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSI 183 D+ +N+L++ N +KL DFGL+R + ++ W P + F + ++++ Sbjct: 164 DIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINF--RRFTSAS 221 Query: 184 DMWSAGCIFAELANAGRPLFPGNDVDDQLKRI 215 D+W G E+ G F G +D + RI Sbjct: 222 DVWMFGVCMWEILMHGVKPFQGVKNNDVIGRI 253 >4PWN-A nrPDB Length = 274 Score = 71.6 bits (174), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 71/289 (24%), Positives = 129/289 (44%), Gaps = 41/289 (14%) Query: 9 KIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHD 68 +IG G++ TV+K + ET VA ++ + E +LK L+H NIVR +D Sbjct: 17 EIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQHPNIVRFYD 76 Query: 69 VLHSDKK----LTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN--V 122 S K + LV E K + + ++++S+ Q+LKGL F H+R + Sbjct: 77 SWESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKGLQFLHTRTPPI 136 Query: 123 LHRDLKPQNLLINR-NGELKLADFGLARAFGIPVRCYSAEVV--TLWYRPPDVLFGAKLY 179 +HRDLK N+ I G +K+ D GLA + R A+ V T + P++ + Y Sbjct: 137 IHRDLKCDNIFITGPTGSVKIGDLGLAT---LEKRASFAKSVIGTPEFMAPEMY--EEKY 191 Query: 180 STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPY 239 S+D+++ G E+A + P + +R+ Sbjct: 192 DESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRV----------------------TS 229 Query: 240 PMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288 + PA+ V +P++ +++++ ++ N +R S ++ L H +F + Sbjct: 230 GVKPASFDKV-AIPEV----KEIIEGCIRQNKDERYSIKDLLNHAFFQE 273 >4AW2-A nrPDB Length = 437 Score = 71.2 bits (173), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 70/296 (23%), Positives = 124/296 (41%), Gaps = 36/296 (12%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALRE-ICLLKELKH 60 + +E L+ IG G +G V K + ++ A+K + + + ++ RE +L Sbjct: 74 EDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDS 133 Query: 61 KNIVRLHDVLHSDKKLTLVFEF-CDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 K I LH D L LV ++ DL L E+ + +L +++ + H Sbjct: 134 KWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEEMARFYLAEMVIAIDSVHQ 193 Query: 120 RNVLHRDLKPQNLLINRNGELKLADFGLA-RAFGIPVRCYSAEVVTLWYRPPDVL----F 174 + +HRD+KP N+L++ NG ++LADFG + S V T Y P++L Sbjct: 194 LHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMEG 253 Query: 175 GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLP 234 G Y D WS G E+ P + + V+ + K+ Sbjct: 254 GKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVE-------------------TYGKIM 294 Query: 235 DYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISA---EEALQHPYFS 287 ++K +P V ++ +DL++ L+ C+ R+ E+ +HP+FS Sbjct: 295 NHKERFQFPTQ------VTDVSENAKDLIRRLI-CSREHRLGQNGIEDFKKHPFFS 343 >5VO2-A nrPDB Length = 300 Score = 71.2 bits (173), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 56/206 (27%), Positives = 87/206 (42%), Gaps = 18/206 (8%) Query: 7 LEKIGEGTYGTVFKAKNRETHEIVALKRVR-LDDDDEGVPSSALREICLLKELKHKNIVR 65 L+ +G G G VF R E VA+K+VR L + D I L++LKH NI+ Sbjct: 17 LQWVGSGAQGAVFLG--RFHGEEVAVKKVRDLKETD----------IKHLRKLKHPNIIT 64 Query: 66 LHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHR 125 V ++ EFC Q + P ++ + + G+ + H ++HR Sbjct: 65 FKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHR 124 Query: 126 DLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDM 185 DLK N+LI + +K++DFG ++ S W P + + S +D+ Sbjct: 125 DLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPE--VIRNEPVSEKVDI 182 Query: 186 WSAGCIFAELANAGRPLFPGNDVDDQ 211 WS G + EL P DVD Sbjct: 183 WSFGVVLWELLTGE---IPYKDVDSS 205 >6BDL-A nrPDB Length = 347 Score = 71.2 bits (173), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 64/299 (21%), Positives = 122/299 (40%), Gaps = 43/299 (14%) Query: 1 MQKYEKLEKIGEGTYGTV----FKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLK 56 + + ++ +G G +G V K++ +T + LK+ + D + +R + Sbjct: 33 LSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQ---QEHIRSEKQIM 89 Query: 57 ELKHKN-IVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLG 115 + H + IVRL+ K L ++ E C G + + + +++ Sbjct: 90 QGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFA 149 Query: 116 FCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFG 175 + HS+ +++RDLKP+NL+++ G KL DFG A+ G + ++ T Y P+++ Sbjct: 150 YLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTF-CGTPEYVAPEIILN 208 Query: 176 AKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPD 235 K + S D WS G + EL G P F G D Sbjct: 209 -KGHDISADYWSLGILMYELL-TGSPPFSGPD---------------------------P 239 Query: 236 YKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRI-----SAEEALQHPYFSDF 289 K Y + ++ K+ +L++ L + NP +R+ ++ +H +F F Sbjct: 240 MKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGF 298 >3HNG-A nrPDB Length = 360 Score = 71.2 bits (173), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 39/109 (35%), Positives = 61/109 (55%), Gaps = 5/109 (4%) Query: 105 SFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLAR-AFGIP--VRCYSAE 161 S+ FQ+ +G+ F SR +HRDL +N+L++ N +K+ DFGLAR + P VR Sbjct: 203 SYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRKGDTR 262 Query: 162 VVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDD 210 + W P + K+YST D+WS G + E+ + G +PG +D+ Sbjct: 263 LPLKWMAPESIF--DKIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDE 309 >4WB7-A nrPDB Length = 405 Score = 70.9 bits (172), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 51/208 (24%), Positives = 106/208 (50%), Gaps = 13/208 (6%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVP----SSALREICLLK 56 + ++E+++ +G G++G V K++ET A+K + D + V L E +L+ Sbjct: 95 LDQFERIKTLGTGSFGRVMLVKHKETGNHYAMK---ILDKQKVVKLKQIEHTLNEKRILQ 151 Query: 57 ELKHKNIVRLHDVLHSDKKLTLVFEFC-DQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLG 115 + +V+L + L +V E+ ++ + +P + + Q++ Sbjct: 152 AVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPH-ARFYAAQIVLTFE 210 Query: 116 FCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFG 175 + HS ++++RDLKP+NLLI++ G +++ DFG A+ + R ++ T Y P+++ Sbjct: 211 YLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKR--VKGRTWTL-CGTPEYLAPEIIL- 266 Query: 176 AKLYSTSIDMWSAGCIFAELANAGRPLF 203 +K Y+ ++D W+ G + E+A P F Sbjct: 267 SKGYNKAVDWWALGVLIYEMAAGYPPFF 294 >6DBM-A nrPDB Length = 318 Score = 70.9 bits (172), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 59/202 (29%), Positives = 99/202 (49%), Gaps = 16/202 (7%) Query: 5 EKLEKIGEGTYGTV----FKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 +K+ +GEG +G V + N T E+VA+K ++ D + S +EI +L+ L H Sbjct: 34 KKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAGPQH-RSGWKQEIDILRTLYH 92 Query: 61 KNIVRLHDVLH--SDKKLTLVFEFCD-QDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFC 117 ++I++ L LV E+ L+ Y + L ++ F Q+ +G+ + Sbjct: 93 EHIIKYKGCCEDAGAASLQLVMEYVPLGSLRDYLPRHSIGLAQLLL--FAQQICEGMAYL 150 Query: 118 HSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCY----SAEVVTLWYRPPDVL 173 HS++ +HRDL +N+L++ + +K+ DFGLA+A Y + WY P+ L Sbjct: 151 HSQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWY-APECL 209 Query: 174 FGAKLYSTSIDMWSAGCIFAEL 195 K Y S D+WS G EL Sbjct: 210 KEYKFYYAS-DVWSFGVTLYEL 230 >6FER-A nrPDB Length = 309 Score = 70.9 bits (172), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 60/216 (27%), Positives = 103/216 (47%), Gaps = 32/216 (14%) Query: 8 EKIGEGTYGTV----------FKAKN------RETHEIVALKRVRLDDDDEGVPSSALRE 51 EK+GEG +G V FK K+ +VA+K +R D + + + L+E Sbjct: 15 EKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADAN-KNARNDFLKE 73 Query: 52 ICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQ-DLKKYF------DSCNGDLDPEIVK 104 I ++ LK NI+ L V +D L ++ E+ + DL ++ +S + D+ Sbjct: 74 IKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPNSSSSDVRTVSYT 133 Query: 105 SFLF---QLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAF--GIPVRCYS 159 + F Q+ G+ + S N +HRDL +N L+ +N +K+ADFG++R G R Sbjct: 134 NLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYYRIQG 193 Query: 160 AEVVTL-WYRPPDVLFGAKLYSTSIDMWSAGCIFAE 194 V+ + W +L G ++T+ D+W+ G E Sbjct: 194 RAVLPIRWMSWESILLGK--FTTASDVWAFGVTLWE 227 >4K33-A nrPDB Length = 325 Score = 70.9 bits (172), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 63/238 (26%), Positives = 117/238 (49%), Gaps = 36/238 (15%) Query: 10 IGEGTYGTVFKA------KNRETHEI-VALKRVRLDDDDEGVPSSALREICLLKEL-KHK 61 +GEG +G V A K+R + VA+K ++ D D+ + S + E+ ++K + KHK Sbjct: 44 LGEGAFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDL-SDLVSEMEMMKMIGKHK 102 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQ-DLKKY------------FDSCNGDLDPEIVKSFL- 107 NI+ L L ++ E+ + +L+++ FD+ + K + Sbjct: 103 NIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTSKPPEEQLTFKDLVS 162 Query: 108 --FQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVT- 164 +Q+ +G+ + S+ +HRDL +N+L+ + +K+ADFGLAR + Y E Sbjct: 163 CAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLAR--DVHNLDYYKETTNG 220 Query: 165 ---LWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLL 219 + + P+ LF ++Y+ D+WS G + E+ G +PG V++ +F+LL Sbjct: 221 RLPVKWMAPEALFD-RVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEE----LFKLL 273 >5FM2-A nrPDB Length = 355 Score = 70.5 bits (171), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 62/248 (25%), Positives = 108/248 (43%), Gaps = 47/248 (18%) Query: 10 IGEGTYGTVFKA-----KNRETHEIVALKRVRLDDDDEGVPSSALR----EICLLKELKH 60 +GEG +G V KA K R + VA+K ++ E S LR E +LK++ H Sbjct: 72 LGEGEFGKVVKATAFHLKGRAGYTTVAVKMLK-----ENASPSELRDLLSEFNVLKQVNH 126 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVK---------------- 104 ++++L+ D L L+ E+ + F + + P + Sbjct: 127 PHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDER 186 Query: 105 --------SFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAF---GI 153 SF +Q+ +G+ + ++HRDL +N+L+ ++K++DFGL+R Sbjct: 187 ALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDS 246 Query: 154 PVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLK 213 V+ + W + LF +Y+T D+WS G + E+ G +PG + Sbjct: 247 YVKRSQGRIPVKWM-AIESLFD-HIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPE---- 300 Query: 214 RIFRLLGT 221 R+F LL T Sbjct: 301 RLFNLLKT 308 >5B2L-A nrPDB Length = 324 Score = 70.5 bits (171), Expect = 9e-13, Method: Compositional matrix adjust. Identities = 53/203 (26%), Positives = 90/203 (44%), Gaps = 8/203 (3%) Query: 5 EKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIV 64 E L ++G GT G V+K + R+T ++A+K++R + E + +LK IV Sbjct: 20 ENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIV 79 Query: 65 RLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN-VL 123 + ++ + + E +K G + I+ ++K L + ++ V+ Sbjct: 80 QCFGTFITNTDVFIAMELMGTSAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVI 139 Query: 124 HRDLKPQNLLINRNGELKLADFGLA-RAFGIPVRCYSAEVVTLW----YRPPDVLFGAKL 178 HRD+KP N+L++ G++KL DFG++ R + SA PPD Sbjct: 140 HRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPT--KPD 197 Query: 179 YSTSIDMWSAGCIFAELANAGRP 201 Y D+WS G ELA P Sbjct: 198 YDIRADVWSLGISLVELATGQFP 220 >4XI2-A nrPDB Length = 446 Score = 69.7 bits (169), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 54/219 (24%), Positives = 106/219 (48%), Gaps = 14/219 (6%) Query: 7 LEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRL 66 L+++G G +G V K R ++ VA+K +R E + E ++ L H+ +V+L Sbjct: 192 LKELGTGQFGVVKYGKWRGQYD-VAIKMIREGSMSE---DEFIEEAKVMMNLSHEKLVQL 247 Query: 67 HDVLHSDKKLTLVFEFCDQD-LKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHR 125 + V + + ++ E+ L Y + + + + + + S+ LHR Sbjct: 248 YGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHR 307 Query: 126 DLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLW---YRPPDVLFGAKLYSTS 182 DL +N L+N G +K++DFGL+R + Y++ V + + + PP+VL +K S S Sbjct: 308 DLAARNCLVNDQGVVKVSDFGLSRY--VLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKS 365 Query: 183 IDMWSAGCIFAELANAGR---PLFPGNDVDDQLKRIFRL 218 D+W+ G + E+ + G+ F ++ + + + RL Sbjct: 366 -DIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRL 403 >3V5Q-A nrPDB Length = 297 Score = 69.7 bits (169), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 59/219 (26%), Positives = 100/219 (45%), Gaps = 27/219 (12%) Query: 9 KIGEGTYGTVFKAKN-----RETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 ++GEG +G VF A+ + +VA+K L D RE LL L+H++I Sbjct: 22 ELGEGAFGKVFLAECYNLSPTKDKMLVAVKA--LKDPTLAARKDFQREAELLTNLQHEHI 79 Query: 64 VRLHDVLHSDKKLTLVFEFCDQ-DLKKYFDS---------------CNGDLDPEIVKSFL 107 V+ + V L +VFE+ DL K+ + G+L + Sbjct: 80 VKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIA 139 Query: 108 FQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIP--VRCYSAEVVTL 165 Q+ G+ + S++ +HRDL +N L+ N +K+ DFG++R R ++ + Sbjct: 140 SQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPI 199 Query: 166 WYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGR-PLF 203 + PP+ + K ++T D+WS G I E+ G+ P F Sbjct: 200 RWMPPESIMYRK-FTTESDVWSFGVILWEIFTYGKQPWF 237 >4C0T-A nrPDB Length = 974 Score = 69.7 bits (169), Expect = 1e-12, Method: Composition-based stats. Identities = 77/304 (25%), Positives = 134/304 (44%), Gaps = 70/304 (23%) Query: 8 EKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVR-- 65 +++GEG+Y TV A ++ T + A+K LD R I K++K+ NI + Sbjct: 272 KELGEGSYSTVILATDKITGKQYAVKV--LDK----------RHIIKEKKVKYVNIEKHA 319 Query: 66 LHDVLHSDKKLTLVFEFCDQDLKKYF---DSCNGDL----------DPEIVKSFLFQLLK 112 L+ + + ++L F F D+D YF + NG+L + E + F Q+L Sbjct: 320 LNRLSNRLGVISLYFTFQDKD-SLYFVLDYASNGELLTLIKRYNTLNEECTRHFGAQILD 378 Query: 113 GLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLAR----------AFGIPVRCYSAEV 162 + + H V+HRDLKP+N+L++ +++ DFG AR + + VR S V Sbjct: 379 AIKYMHDNGVIHRDLKPENILLDDKMRIQITDFGTARLLEKKNDESEEYPVDVRAKSF-V 437 Query: 163 VTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTP 222 T Y P++L K D+W+ GCI ++ AG+P F + ++I +L Sbjct: 438 GTAEYVSPELLEN-KYCGKPGDVWAFGCIIYQMI-AGKPPFKATNEYLTFQKITKL---- 491 Query: 223 TEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQ 282 + + ++ RDL++ +L P +R + E + Sbjct: 492 ------------------QFAFSAGFPTII-------RDLIKKILVLQPSRRATIPEIQK 526 Query: 283 HPYF 286 H +F Sbjct: 527 HYFF 530 >4E20-A nrPDB Length = 290 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 60/205 (29%), Positives = 101/205 (49%), Gaps = 22/205 (10%) Query: 5 EKLEKIGEGTYGTV----FKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 +K+ +GEG +G V + N T E+VA+K ++ + + S REI +L+ L H Sbjct: 11 KKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALK-EGCGPQLRSGWQREIEILRTLYH 69 Query: 61 KNIVRLHDVL--HSDKKLTLVFEFCD-QDLKKYF-DSCNGDLDPEIVKSFLF--QLLKGL 114 ++IV+ +K + LV E+ L+ Y C G + + LF Q+ +G+ Sbjct: 70 EHIVKYKGCCEDQGEKSVQLVMEYVPLGSLRDYLPRHCVG-----LAQLLLFAQQICEGM 124 Query: 115 GFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCY----SAEVVTLWYRPP 170 + H+++ +HR L +N+L++ + +K+ DFGLA+A Y + WY P Sbjct: 125 AYLHAQHYIHRALAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWY-AP 183 Query: 171 DVLFGAKLYSTSIDMWSAGCIFAEL 195 + L K Y S D+WS G EL Sbjct: 184 ECLKECKFYYAS-DVWSFGVTLYEL 207 >2Y4I-B nrPDB Length = 319 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 40/153 (26%), Positives = 79/153 (51%), Gaps = 5/153 (3%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 ++ E E IG+G +G V+ + H VA++ + ++ D+E + RE+ ++ +H+ Sbjct: 33 EQLEIGELIGKGRFGQVYHGR---WHGEVAIRLIDIERDNEDQLKAFKREVMAYRQTRHE 89 Query: 62 NIVRLHDVLHSDKKLTLVFEFCD-QDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 N+V S L ++ C + L LD + +++KG+G+ H++ Sbjct: 90 NVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAK 149 Query: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAFGI 153 +LH+DLK +N+ + NG++ + DFGL G+ Sbjct: 150 GILHKDLKSKNVFYD-NGKVVITDFGLFSISGV 181 >6FEX-A nrPDB Length = 321 Score = 69.3 bits (168), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 59/236 (25%), Positives = 103/236 (43%), Gaps = 33/236 (13%) Query: 8 EKIGEGTYGTV---------------FKAKNRETHEIVALKRVRLDDDDEGVPSSALREI 52 EK+GEG +G V F R+ H ++ ++ D + + L+E+ Sbjct: 22 EKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEV 81 Query: 53 CLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQ-DLKKYFDSC--------NGDLDPEIV 103 ++ LK NI+RL V D L ++ ++ + DL ++ + DP I Sbjct: 82 KIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAPGDPTIS 141 Query: 104 KSFLF----QLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAF--GIPVRC 157 L Q+ G+ + + N +HRDL +N L+ N +K+ADFG++R G R Sbjct: 142 YPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRV 201 Query: 158 YSAEVVTL-WYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQL 212 V+ + W +L G ++T+ D+W+ G E+ R G D+Q+ Sbjct: 202 QGRAVLPIRWMAWECILMGK--FTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQV 255 >5L6P-A nrPDB Length = 298 Score = 69.3 bits (168), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 55/224 (24%), Positives = 106/224 (47%), Gaps = 16/224 (7%) Query: 8 EKIGEGTYGTVFKAKNRETHE---IVALKRVRLDDDDEGVPSSALREICLLKELKHKNIV 64 E IG G +G V + + ++ VA+K +++ E L E ++ + H NI+ Sbjct: 25 EVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYT-ERQRRDFLSEASIMGQFDHPNII 83 Query: 65 RLHDVLHSDKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVL 123 RL V+ + + ++ EF + L + +G + L + G+ + N + Sbjct: 84 RLEGVVTKSRPVMILTEFMENCALDSFLRLNDGQFTVIQLVGMLRGIAAGMKYLSEMNYV 143 Query: 124 HRDLKPQNLLINRNGELKLADFGLARAF----GIPVRCYS--AEVVTLWYRPPDVLFGAK 177 HRDL +N+L+N N K++DFGL+R P S ++ W P + + + Sbjct: 144 HRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTAPEAIAY--R 201 Query: 178 LYSTSIDMWSAGCIFAELANAG-RPLF--PGNDVDDQLKRIFRL 218 ++++ D+WS G + E+ + G RP + DV + +++ +RL Sbjct: 202 KFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVEQDYRL 245 >3G0E-A nrPDB Length = 336 Score = 69.3 bits (168), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 78/308 (25%), Positives = 123/308 (39%), Gaps = 87/308 (28%) Query: 8 EKIGEGTYGTVFKAK-----NRETHEIVALKRVRLDDDDEGVPSSALREI-CLLKELK-- 59 + +G G +G V +A + VA+K ++ PS+ L E L+ ELK Sbjct: 52 KTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLK--------PSAHLTEREALMSELKVL 103 Query: 60 -----HKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDL---------------- 98 H NIV L ++ E+C C GDL Sbjct: 104 SYLGNHMNIVNLLGACTIGGPTLVITEYC----------CYGDLLNFLRRKRDSFICSKT 153 Query: 99 DPEIVK------------SFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFG 146 P I++ SF +Q+ KG+ F S+N +HRDL +N+L+ K+ DFG Sbjct: 154 SPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFG 213 Query: 147 LARAFGIPVRCYSAEVVT------LWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGR 200 LAR ++ S VV + + P+ +F +Y+ D+WS G EL + G Sbjct: 214 LAR----DIKNDSNYVVKGNARLPVKWMAPESIFNC-VYTFESDVWSYGIFLWELFSLGS 268 Query: 201 PLFPGNDVDDQ----LKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLN 256 +PG VD + +K FR+L P++ P MY + + P Sbjct: 269 SPYPGMPVDSKFYKMIKEGFRMLS-------------PEHAPAEMYDIMKTCWDADPLKR 315 Query: 257 ATGRDLLQ 264 T + ++Q Sbjct: 316 PTFKQIVQ 323 >2VWV-A nrPDB Length = 302 Score = 69.3 bits (168), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 57/230 (24%), Positives = 109/230 (47%), Gaps = 17/230 (7%) Query: 3 KYEKLEK-IGEGTYGTVFKAKNR---ETHEIVALKRVRLDDDDEGVPSSALREICLLKEL 58 Y K+E+ IG G +G V + + + + VA+K ++ E L E ++ + Sbjct: 16 SYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLK-GGYTERQRREFLSEASIMGQF 74 Query: 59 KHKNIVRLHDVLHSDKKLTLVFEFCDQD-LKKYFDSCNGDLDPEIVKSFLFQLLKGLGFC 117 +H NI+RL V+ + + ++ EF + L + +G + L + G+ + Sbjct: 75 EHPNIIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGMRYL 134 Query: 118 HSRNVLHRDLKPQNLLINRNGELKLADFGLARAF----GIPVRCYS--AEVVTLWYRPPD 171 + +HRDL +N+L+N N K++DFGL+R P S ++ W P Sbjct: 135 AEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTETSSLGGKIPIRWTAPEA 194 Query: 172 VLFGAKLYSTSIDMWSAGCIFAELANAG-RPLF--PGNDVDDQLKRIFRL 218 + F + ++++ D WS G + E+ + G RP + DV + +++ +RL Sbjct: 195 IAF--RKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRL 242 >4WUA-A nrPDB Length = 401 Score = 68.9 bits (167), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 81/366 (22%), Positives = 147/366 (40%), Gaps = 88/366 (24%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62 +Y + K+G G + TV+ + + + + VA+K V+ E +AL EI LLK +++ + Sbjct: 42 RYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVK---SAEHYTETALDEIRLLKSVRNSD 98 Query: 63 --------IVRLHDVLH----SDKKLTLVFEFCDQDLKKYFDSCNGDLDP-EIVKSFLFQ 109 +V+L D + + +VFE L K+ N P VK + Q Sbjct: 99 PNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQ 158 Query: 110 LLKGLGFCHSR-NVLHRDLKPQNLLINRNGE----------------------------- 139 +L+GL + H++ ++H D+KP+N+L++ N + Sbjct: 159 VLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVSTAP 218 Query: 140 --------------------LKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLY 179 +K+AD G A + ++ ++ T YR +VL G+ Y Sbjct: 219 ATAGNFLVNPLEPKNAEKLKVKIADLGNACWVH---KHFTEDIQTRQYRSLEVLIGSG-Y 274 Query: 180 STSIDMWSAGCIFAELANAGRPLFPGNDV-----DDQLKRIFRLLGTPTEE--------- 225 +T D+WS C+ ELA P + +D + I LLG + Sbjct: 275 NTPADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSK 334 Query: 226 ----QWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEAL 281 + + + KP+ ++ + A D L +L+ P +R +A E L Sbjct: 335 EFFTKKGDLKHITKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATAAECL 394 Query: 282 QHPYFS 287 +HP+ + Sbjct: 395 RHPWLN 400 >5X3F-B nrPDB Length = 393 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 49/208 (23%), Positives = 106/208 (50%), Gaps = 13/208 (6%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVP----SSALREICLLK 56 + ++++++ +G G++G V K++E+ A+K + D + V L E +L+ Sbjct: 83 LDQFDRIKTLGTGSFGRVMLVKHKESGNHYAMKIL---DKQKVVKLKQIEHTLNEKRILQ 139 Query: 57 ELKHKNIVRLHDVLHSDKKLTLVFEF-CDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLG 115 + +V+L + L +V E+ ++ + +P + + Q++ Sbjct: 140 AVNFPFLVKLEFSFKDNSNLYMVMEYVAGGEMFSHLRRIGRFSEPH-ARFYAAQIVLTFE 198 Query: 116 FCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFG 175 + HS ++++RDLKP+NLLI++ G +++ DFG A+ + R ++ T Y P+++ Sbjct: 199 YLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKR--VKGRTWTL-CGTPEYLAPEIIL- 254 Query: 176 AKLYSTSIDMWSAGCIFAELANAGRPLF 203 +K Y+ ++D W+ G + E+A P F Sbjct: 255 SKGYNKAVDWWALGVLIYEMAAGYPPFF 282 >4C59-A nrPDB Length = 340 Score = 68.6 bits (166), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 56/213 (26%), Positives = 98/213 (46%), Gaps = 35/213 (16%) Query: 10 IGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELK-HKNIVRLHD 68 + EG + V++A++ + ALKR+ +++++ + ++E+C +K+L H NIV+ Sbjct: 35 LAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKN--RAIIQEVCFMKKLSGHPNIVQFCS 92 Query: 69 VLHSDKK--------LTLVFEFCDQDLKKYFD--SCNGDLDPEIVKSFLFQLLKGLGFCH 118 K+ L+ E C L ++ G L + V +Q + + H Sbjct: 93 AASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGPLSCDTVLKIFYQTCRAVQHMH 152 Query: 119 SRN--VLHRDLKPQNLLINRNGELKLADFGLARAFG-IPVRCYSAEV-----------VT 164 + ++HRDLK +NLL++ G +KL DFG A P +SA+ T Sbjct: 153 RQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEEEITRNTT 212 Query: 165 LWYRPPDVLFGAKLYST-----SIDMWSAGCIF 192 YR P+++ LYS D+W+ GCI Sbjct: 213 PMYRTPEII---DLYSNFPIGEKQDIWALGCIL 242 >5HI2-A nrPDB Length = 283 Score = 68.6 bits (166), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 51/215 (23%), Positives = 104/215 (48%), Gaps = 14/215 (6%) Query: 8 EKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLH 67 ++IG G++GTV+K K H VA+K + + E+ +L++ +H NI+ L Sbjct: 26 QRIGSGSFGTVYKGK---WHGDVAVKMLTPQQ-----LQAFKNEVGVLRKTRHVNIL-LF 76 Query: 68 DVLHSDKKLTLVFEFCD-QDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRD 126 + +L +V ++C+ L + + + + + Q +G+ + H+++++HRD Sbjct: 77 MGYSTKPQLAIVTQWCEGSSLYHHLHASETKFEMKKLIDIARQTARGMDYLHAKSIIHRD 136 Query: 127 LKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVT---LWYRPPDV-LFGAKLYSTS 182 LK N+ ++ + +K+ DFGLA + E ++ LW P + + + YS Sbjct: 137 LKSNNIFLHEDNTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDSNPYSFQ 196 Query: 183 IDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFR 217 D+++ G + EL P N+ D ++ + R Sbjct: 197 SDVYAFGIVLYELMTGQLPYSNINNRDQIIEMVGR 231 >3C1X-A nrPDB Length = 373 Score = 68.2 bits (165), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 64/248 (25%), Positives = 111/248 (44%), Gaps = 29/248 (11%) Query: 8 EKIGEGTYGTVFKAK-----NRETH-EIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 E IG G +G V+ ++ H + +L R+ D G S L E ++K+ H Sbjct: 95 EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRIT----DIGEVSQFLTEGIIMKDFSHP 150 Query: 62 NIVRLHDV-LHSDKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 N++ L + L S+ +V + DL+ + + + + + F Q+ KG+ F S Sbjct: 151 NVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKFLAS 210 Query: 120 RNVLHRDLKPQNLLINRNGELKLADFGLAR-----AFGIPVRCYSAEVVTLWYRPPDVLF 174 + +HRDL +N +++ +K+ADFGLAR F A++ W + Sbjct: 211 KKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEFDSVHNKTGAKLPVKWMALESL-- 268 Query: 175 GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLP 234 + ++T D+WS G + EL G P +P DV+ ++ L G + P Sbjct: 269 QTQKFTTKSDVWSFGVLLWELMTRGAPPYP--DVNTFDITVYLLQGRRLLQ--------P 318 Query: 235 DYKPYPMY 242 +Y P P+Y Sbjct: 319 EYCPDPLY 326 >2J0K-A nrPDB Length = 656 Score = 68.2 bits (165), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 52/212 (24%), Positives = 97/212 (45%), Gaps = 10/212 (4%) Query: 10 IGEGTYGTVFKAKNRETHE---IVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRL 66 IGEG +G V + VA+K + D V L+E +++ H +IV+L Sbjct: 398 IGEGQFGDVHQGIYMSPENPAMAVAIKTCKNCTSD-SVREKFLQEALTMRQFDHPHIVKL 456 Query: 67 HDVLHSDKKLTLVFEFCD-QDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHR 125 V+ ++ + ++ E C +L+ + LD + + +QL L + S+ +HR Sbjct: 457 IGVI-TENPVWIIMELCTLGELRSFLQVRKFSLDLASLILYAYQLSTALAYLESKRFVHR 515 Query: 126 DLKPQNLLINRNGELKLADFGLARAF--GIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSI 183 D+ +N+L++ +KL DFGL+R + ++ W P + F + ++++ Sbjct: 516 DIAARNVLVSATDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINF--RRFTSAS 573 Query: 184 DMWSAGCIFAELANAGRPLFPGNDVDDQLKRI 215 D+W G E+ G F G +D + RI Sbjct: 574 DVWMFGVCMWEILMHGVKPFQGVKNNDVIGRI 605 >3M42-A nrPDB Length = 299 Score = 68.2 bits (165), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 79/289 (27%), Positives = 117/289 (40%), Gaps = 66/289 (22%) Query: 10 IGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICL-LKELKHKNIVRLHD 68 +G G G V + N+ T E ALK + + P A RE+ L + + +IVR+ D Sbjct: 26 LGLGINGKVLQIFNKRTQEKFALKML------QDCPK-ARREVELHWRASQCPHIVRIVD 78 Query: 69 V---LHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLG----FCHSRN 121 V L++ +K L+ C D + F D + +++K +G + HS N Sbjct: 79 VYENLYAGRKCLLIVMEC-LDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSIN 137 Query: 122 VLHRDLKPQNLLINR---NGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL 178 + HRD+KP+NLL N LKL DFG A+ G K Sbjct: 138 IAHRDVKPENLLYTSKRPNAILKLTDFGFAKE----------------------TTGEK- 174 Query: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYK- 237 Y S DMWS G I L G P F N G + ++ Y+ Sbjct: 175 YDKSCDMWSLGVIMYILL-CGYPPFYSNH------------GLAISPGMKTRIRMGQYEF 221 Query: 238 PYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286 P P + + V + L++NLLK P QR++ E + HP+ Sbjct: 222 PNPEWSEVSEEVKM----------LIRNLLKTEPTQRMTITEFMNHPWI 260 >4H1J-A nrPDB Length = 293 Score = 67.8 bits (164), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 72/270 (26%), Positives = 124/270 (45%), Gaps = 28/270 (10%) Query: 10 IGEGTYGTVFKA--KNRETHEI-VALKRVRLD---DDDEGVPSSALREICLLKELKHKNI 63 +GEG +G V++ N + +I VA+K + D D+ E S A+ ++K L H +I Sbjct: 32 LGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAV----IMKNLDHPHI 87 Query: 64 VRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVL 123 V+L ++ + ++ + +L Y + L + + Q+ K + + S N + Sbjct: 88 VKLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINCV 147 Query: 124 HRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTL---WYRPPDVLFGAKLYS 180 HRD+ +N+L+ +KL DFGL+R Y A V L W P + F + ++ Sbjct: 148 HRDIAVRNILVASPECVKLGDFGLSRYIE-DEDYYKASVTRLPIKWMSPESINF--RRFT 204 Query: 181 TSIDMWS-AGCIFAELANAGRPLF--PGNDVDDQLKRIFRLLGTPTEEQWPS-----MTK 232 T+ D+W A C++ L+ +P F DV L++ RL P + P MT+ Sbjct: 205 TASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRL---PKPDLCPPVLYTLMTR 261 Query: 233 LPDYKPYPMYPATTSLVNVVPKLNATGRDL 262 DY P P T LV + + +D+ Sbjct: 262 CWDYDPSDR-PRFTELVCSLSDVYQMEKDI 290 >4XUF-A nrPDB Length = 297 Score = 67.8 bits (164), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 69/282 (24%), Positives = 118/282 (41%), Gaps = 45/282 (15%) Query: 10 IGEGTYGTVFKAKNRETHEI-----VALKRVRLDDDDEGVPSSALREICLLKEL-KHKNI 63 +G G +G V A + VA+K ++ + D + + E+ ++ +L H+NI Sbjct: 17 LGSGAFGKVMNATAYGISKTGVSIQVAVKMLK-EKADSSEREALMSELKMMTQLGSHENI 75 Query: 64 VRLHDVLHSDKKLTLVFEFC-DQDLKKYFDSCNGDLDPEIVK------------------ 104 V L + L+FE+C DL Y S + ++ Sbjct: 76 VNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRLEEEEDLNVLTF 135 Query: 105 ----SFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAF----GIPVR 156 F +Q+ KG+ F ++ +HRDL +N+L+ +K+ DFGLAR VR Sbjct: 136 EDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVR 195 Query: 157 CYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIF 216 +A + W P + G +Y+ D+WS G + E+ + G +PG VD ++ Sbjct: 196 G-NARLPVKWMAPESLFEG--IYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLI 252 Query: 217 R---LLGTP---TEEQWPSMTKLP--DYKPYPMYPATTSLVN 250 + + P TEE + M D + P +P TS + Sbjct: 253 QNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLG 294 >1U59-A nrPDB Length = 287 Score = 67.8 bits (164), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 53/199 (26%), Positives = 95/199 (47%), Gaps = 11/199 (5%) Query: 9 KIGEGTYGTVFKA--KNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRL 66 ++G G +G+V + + R+ VA+K ++ ++ +RE ++ +L + IVRL Sbjct: 17 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLK-QGTEKADTEEMMREAQIMHQLDNPYIVRL 75 Query: 67 HDVLHSDKKLTLVFEFCDQD-LKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHR 125 V ++ L LV E L K+ ++ V L Q+ G+ + +N +HR Sbjct: 76 IGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHR 134 Query: 126 DLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVT----LWYRPPDVLFGAKLYST 181 DL +N+L+ K++DFGL++A G Y+A WY P + F + +S+ Sbjct: 135 DLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINF--RKFSS 192 Query: 182 SIDMWSAGCIFAELANAGR 200 D+WS G E + G+ Sbjct: 193 RSDVWSYGVTMWEALSYGQ 211 >6E4F-A nrPDB Length = 290 Score = 67.8 bits (164), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 53/219 (24%), Positives = 106/219 (48%), Gaps = 14/219 (6%) Query: 7 LEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRL 66 L+++G G +G V K R ++ VA+K ++ E + E ++ L H+ +V+L Sbjct: 36 LKELGTGQFGVVKYGKWRGQYD-VAIKMIKEGSMSE---DEFIEEAKVMMNLSHEKLVQL 91 Query: 67 HDVLHSDKKLTLVFEFCDQD-LKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHR 125 + V + + ++ E+ L Y + + + + + + S+ LHR Sbjct: 92 YGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHR 151 Query: 126 DLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLW---YRPPDVLFGAKLYSTS 182 DL +N L+N G +K++DFGL+R + Y++ V + + + PP+VL +K S S Sbjct: 152 DLAARNCLVNDQGVVKVSDFGLSRY--VLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKS 209 Query: 183 IDMWSAGCIFAELANAGR---PLFPGNDVDDQLKRIFRL 218 D+W+ G + E+ + G+ F ++ + + + RL Sbjct: 210 -DIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRL 247 >5X02-A nrPDB Length = 347 Score = 67.8 bits (164), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 69/281 (24%), Positives = 118/281 (41%), Gaps = 45/281 (16%) Query: 10 IGEGTYGTVFKAKNRETHEI-----VALKRVRLDDDDEGVPSSALREICLLKEL-KHKNI 63 +G G +G V A + VA+K ++ + D + + E+ ++ +L H+NI Sbjct: 56 LGSGAFGKVMNATAYGISKTGVSIQVAVKMLK-EKADSSEREALMSELKMMTQLGSHENI 114 Query: 64 VRLHDVLHSDKKLTLVFEFC-DQDLKKYFDSCNGDLDPEIVK------------------ 104 V L + L+FE+C DL Y S + ++ Sbjct: 115 VNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRLEEEEDLNVLTF 174 Query: 105 ----SFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAF----GIPVR 156 F +Q+ KG+ F ++ +HRDL +N+L+ +K+ DFGLAR VR Sbjct: 175 EDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVR 234 Query: 157 CYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIF 216 +A + W P + G +Y+ D+WS G + E+ + G +PG VD ++ Sbjct: 235 G-NARLPVKWMAPESLFEG--IYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLI 291 Query: 217 R---LLGTP---TEEQWPSMTKLP--DYKPYPMYPATTSLV 249 + + P TEE + M D + P +P TS + Sbjct: 292 QNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFL 332 >3LZB-A nrPDB Length = 327 Score = 67.8 bits (164), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 58/229 (25%), Positives = 109/229 (47%), Gaps = 19/229 (8%) Query: 3 KYEKLEKIGEGTYGTVFKA----KNRETHEIVALKRVRLDDDDEGVPSSALREICLLKEL 58 +++K++ +G G +GTV+K + + VA+K +R + L E ++ + Sbjct: 16 EFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELR-EATSPKANKEILDEAYVMASV 74 Query: 59 KHKNIVRLHDV-LHSDKKL-TLVFEF-CDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLG 115 + ++ RL + L S +L T + F C D Y ++ + + ++ Q+ KG+ Sbjct: 75 DNPHVCRLLGICLTSTVQLITQLMPFGCLLD---YVREHKDNIGSQYLLNWCVQIAKGMN 131 Query: 116 FCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAE---VVTLWYRPPDV 172 + R ++HRDL +N+L+ +K+ DFGLA+ G + Y AE V W + Sbjct: 132 YLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESI 191 Query: 173 LFGAKLYSTSIDMWSAGCIFAELANAGRPLF---PGNDVDDQLKRIFRL 218 L ++Y+ D+WS G EL G + P +++ L++ RL Sbjct: 192 LH--RIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERL 238 >5IKW-A nrPDB Length = 310 Score = 67.4 bits (163), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 64/214 (29%), Positives = 108/214 (50%), Gaps = 33/214 (15%) Query: 8 EKIGEGTYGTVFKAKNRETHEIV--ALKRVRLDDDDEGVPSSALREICLLKELK-HKNIV 64 E + EG + TVF + TH + ALKR+ +++ + + REI ++KEL HKNIV Sbjct: 20 ESLAEGGFSTVFLVR---THGGIRCALKRMYVNNMPD--LNVCKREITIMKELSGHKNIV 74 Query: 65 -----RLHDVLHSDKKLTLVFEFCD-----QDLKKYFDSCNGDLDPEIVKSFL--FQLLK 112 ++ + + ++ ++ E+C + K + G +PE+++ F + + Sbjct: 75 GYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQT--GFTEPEVLQIFCDTCEAVA 132 Query: 113 GLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLA-RAFGIP----VRCYSAEV---VT 164 L C + ++HRDLK +N+L+N G L DFG A F P V E+ T Sbjct: 133 RLHQCKTP-IIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTT 191 Query: 165 LWYRPPDV--LFGAKLYSTSIDMWSAGCIFAELA 196 L YR P++ L+G K +T D+W+ GC+ +L Sbjct: 192 LSYRAPEMINLYGGKPITTKADIWALGCLLYKLC 225 >5GNK-A nrPDB Length = 297 Score = 67.4 bits (163), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 52/226 (23%), Positives = 104/226 (46%), Gaps = 13/226 (5%) Query: 3 KYEKLEKIGEGTYGTVFKA----KNRETHEIVALKRVRLDDDDEGVPSSALREICLLKEL 58 +++K++ +G G +GTV+K + + VA+K +R + L E ++ + Sbjct: 20 EFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELR-EATSPKANKEILDEAYVMASV 78 Query: 59 KHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCH 118 + ++ RL + + ++ L Y ++ + + ++ Q+ KG+ + Sbjct: 79 DNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLE 138 Query: 119 SRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAE---VVTLWYRPPDVLFG 175 R ++HRDL +N+L+ +K+ DFGLA+ G + Y AE V W +L Sbjct: 139 DRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILH- 197 Query: 176 AKLYSTSIDMWSAGCIFAELANAGRPLF---PGNDVDDQLKRIFRL 218 ++Y+ D+WS G EL G + P +++ L++ RL Sbjct: 198 -RIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERL 242 >1K9A-A nrPDB Length = 450 Score = 67.4 bits (163), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 55/218 (25%), Positives = 106/218 (48%), Gaps = 13/218 (5%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 M++ + L+ IG+G +G V R VA+K ++ ++ + L E ++ +L+H Sbjct: 192 MKELKLLQTIGKGEFGDVMLGDYRGNK--VAVKCIK----NDATAQAFLAEASVMTQLRH 245 Query: 61 KNIVRLHDVLHSDKK-LTLVFEFCDQ-DLKKYFDS-CNGDLDPEIVKSFLFQLLKGLGFC 117 N+V+L V+ +K L +V E+ + L Y S L + + F + + + + Sbjct: 246 SNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYL 305 Query: 118 HSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAK 177 N +HRDL +N+L++ + K++DFGL + + ++ W P + K Sbjct: 306 EGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQD--TGKLPVKWTAPEALR--EK 361 Query: 178 LYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRI 215 +ST D+WS G + E+ + GR +P + D + R+ Sbjct: 362 KFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRV 399 >5KMM-A nrPDB Length = 329 Score = 67.4 bits (163), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 55/214 (25%), Positives = 97/214 (45%), Gaps = 25/214 (11%) Query: 9 KIGEGTYGTVFKAKNR-----ETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 ++GEG +G VF A+ + +VA+K L + E RE LL L+H++I Sbjct: 42 ELGEGAFGKVFLAECHNLLPEQDKMLVAVKA--LKEASESARQDFQREAELLTMLQHQHI 99 Query: 64 VRLHDVLHSDKKLTLVFEFCDQ-DLKKYF--------------DSCNGDLDPEIVKSFLF 108 VR V + L +VFE+ DL ++ D G L + + Sbjct: 100 VRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVAS 159 Query: 109 QLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIP--VRCYSAEVVTLW 166 Q+ G+ + + +HRDL +N L+ + +K+ DFG++R R ++ + Sbjct: 160 QVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIR 219 Query: 167 YRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGR 200 + PP+ + K ++T D+WS G + E+ G+ Sbjct: 220 WMPPESILYRK-FTTESDVWSFGVVLWEIFTYGK 252 >3PLS-A nrPDB Length = 298 Score = 67.4 bits (163), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 57/214 (26%), Positives = 98/214 (45%), Gaps = 37/214 (17%) Query: 10 IGEGTYGTVF------KAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 IG+G +G V+ +A+NR I +L R+ E LRE L++ L H N+ Sbjct: 29 IGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAF----LREGLLMRGLNHPNV 84 Query: 64 VRLHDVLHSDKKL--TLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN 121 + L ++ + L L+ C DL ++ S + + + SF Q+ +G+ + + Sbjct: 85 LALIGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLAEQK 144 Query: 122 VLHRDLKPQNLLINRNGELKLADFGLARAF--------------GIPVRCYSAEVVTLWY 167 +HRDL +N +++ + +K+ADFGLAR +PV+ + E + Y Sbjct: 145 FVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWTALESLQT-Y 203 Query: 168 RPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRP 201 R ++T D+WS G + EL G P Sbjct: 204 R----------FTTKSDVWSFGVLLWELLTRGAP 227 >3C51-A nrPDB Length = 543 Score = 67.4 bits (163), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 69/292 (23%), Positives = 121/292 (41%), Gaps = 43/292 (14%) Query: 10 IGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVP-SSALREICLLKELKHKNIVRLHD 68 +G G +G VF + + T ++ A K++ + A+ E +L ++ + IV L Sbjct: 193 LGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILAKVHSRFIVSLAY 252 Query: 69 VLHSDKKLTLVFEFCDQDLKKY----FDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLH 124 + L LV + +Y D N + Q++ GL H RN+++ Sbjct: 253 AFETKTDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQIVSGLEHLHQRNIIY 312 Query: 125 RDLKPQNLLINRNGELKLADFGLA---RAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYST 181 RDLKP+N+L++ +G ++++D GLA +A + Y+ T + P++L G + Y Sbjct: 313 RDLKPENVLLDDDGNVRISDLGLAVELKAGQTKTKGYAG---TPGFMAPELLLGEE-YDF 368 Query: 182 SIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPM 241 S+D ++ G E+ A P FR G E + L YP Sbjct: 369 SVDYFALGVTLYEMIAARGP--------------FRARGEKVENKELKQRVLEQAVTYP- 413 Query: 242 YPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRI-----SAEEALQHPYFSD 288 K + +D + LL+ +P +R+ S + HP F D Sbjct: 414 -----------DKFSPASKDFCEALLQKDPEKRLGFRDGSCDGLRTHPLFRD 454 >2R2P-A nrPDB Length = 295 Score = 67.0 bits (162), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 57/222 (25%), Positives = 101/222 (45%), Gaps = 18/222 (8%) Query: 10 IGEGTYGTVFKAK-----NRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIV 64 IG G +G V + RE VA+K +++ E L E ++ + H NI+ Sbjct: 30 IGAGEFGEVCSGRLKLPGKRELP--VAIKTLKVGYT-EKQRRDFLGEASIMGQFDHPNII 86 Query: 65 RLHDVLHSDKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVL 123 L V+ K + +V E+ + L + +G + L + G+ + + Sbjct: 87 HLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGISAGMKYLSDMGYV 146 Query: 124 HRDLKPQNLLINRNGELKLADFGLARAF-GIPVRCYS---AEVVTLWYRPPDVLFGAKLY 179 HRDL +N+LIN N K++DFGL+R P Y+ ++ W P + F + + Sbjct: 147 HRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAF--RKF 204 Query: 180 STSIDMWSAGCIFAELANAG-RPLF--PGNDVDDQLKRIFRL 218 +++ D+WS G + E+ + G RP + DV ++ +RL Sbjct: 205 TSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRL 246 >2VD5-A nrPDB Length = 412 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 75/297 (25%), Positives = 120/297 (40%), Gaps = 42/297 (14%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRV-RLDDDDEGVPSSALREICLLKELKHKN 62 +E L+ IG G + V K ++T ++ A+K + + D G S E +L + Sbjct: 63 FEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDRRW 122 Query: 63 IVRLHDVLHSDKKLTLVFEF-CDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN 121 I +LH + L LV E+ DL + E+ + +L +++ + H Sbjct: 123 ITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHRLG 182 Query: 122 VLHRDLKPQNLLINRNGELKLADFGLA---RAFGIPVRCYSAEVVTLWYRPPDVLFGAKL 178 +HRD+KP N+L++R G ++LADFG RA G VR A V T Y P++L Sbjct: 183 YVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGT-VRSLVA-VGTPDYLSPEILQAVGG 240 Query: 179 YST------SIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTK 232 D W+ G E+ P + + + + K Sbjct: 241 GPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAE-------------------TYGK 281 Query: 233 LPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRI---SAEEALQHPYF 286 + YK + SL V + RD +Q LL C P R+ A + HP+F Sbjct: 282 IVHYKEH------LSLPLVDEGVPEEARDFIQRLL-CPPETRLGRGGAGDFRTHPFF 331 >1BYG-A nrPDB Length = 278 Score = 66.6 bits (161), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 56/225 (24%), Positives = 107/225 (47%), Gaps = 27/225 (12%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 M++ + L+ IG+G +G V R VA+K ++ ++ + L E ++ +L+H Sbjct: 20 MKELKLLQTIGKGEFGDVMLGDYRGNK--VAVKCIK----NDATAQAFLAEASVMTQLRH 73 Query: 61 KNIVRLHDVLHSDKK-LTLVFEFCDQ-DLKKYFDS-CNGDLDPEIVKSFLFQLLKGLGFC 117 N+V+L V+ +K L +V E+ + L Y S L + + F + + + + Sbjct: 74 SNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYL 133 Query: 118 HSRNVLHRDLKPQNLLINRNGELKLADFGLARAFG-------IPVRCYSAEVVTLWYRPP 170 N +HRDL +N+L++ + K++DFGL + +PV+ + E + Sbjct: 134 EGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALR------ 187 Query: 171 DVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRI 215 K +ST D+WS G + E+ + GR +P + D + R+ Sbjct: 188 -----EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRV 227 >3SXS-A nrPDB Length = 268 Score = 66.6 bits (161), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 50/198 (25%), Positives = 97/198 (48%), Gaps = 11/198 (5%) Query: 7 LEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRL 66 L+++G G +G V K + ++ VA+K ++ E +E + +L H +V+ Sbjct: 13 LKELGSGQFGVVKLGKWKGQYD-VAVKMIKEGSMSE---DEFFQEAQTMMKLSHPKLVKF 68 Query: 67 HDVLHSDKKLTLVFEFCDQD-LKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHR 125 + V + + +V E+ L Y S L+P + + + +G+ F S +HR Sbjct: 69 YGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQFIHR 128 Query: 126 DLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLW---YRPPDVLFGAKLYSTS 182 DL +N L++R+ +K++DFG+ R + Y + V T + + P+V K YS+ Sbjct: 129 DLAARNCLVDRDLCVKVSDFGMTRY--VLDDQYVSSVGTKFPVKWSAPEVFHYFK-YSSK 185 Query: 183 IDMWSAGCIFAELANAGR 200 D+W+ G + E+ + G+ Sbjct: 186 SDVWAFGILMWEVFSLGK 203 >2OZO-A nrPDB Length = 613 Score = 66.6 bits (161), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 52/199 (26%), Positives = 95/199 (47%), Gaps = 11/199 (5%) Query: 9 KIGEGTYGTVFKA--KNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRL 66 ++G G +G+V + + R+ VA+K ++ ++ +RE ++ +L + IVRL Sbjct: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLK-QGTEKADTEEMMREAQIMHQLDNPYIVRL 401 Query: 67 HDVLHSDKKLTLVFEFCDQD-LKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHR 125 V ++ L LV E L K+ ++ V L Q+ G+ + +N +HR Sbjct: 402 IGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHR 460 Query: 126 DLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVT----LWYRPPDVLFGAKLYST 181 +L +N+L+ K++DFGL++A G Y+A WY P + F + +S+ Sbjct: 461 NLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINF--RKFSS 518 Query: 182 SIDMWSAGCIFAELANAGR 200 D+WS G E + G+ Sbjct: 519 RSDVWSYGVTMWEALSYGQ 537 >5HLW-A nrPDB Length = 299 Score = 66.6 bits (161), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 63/257 (24%), Positives = 112/257 (43%), Gaps = 47/257 (18%) Query: 8 EKIGEGTYGTVFKAK-----NRETH-EIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 E IG G +G V+ ++ H + +L R+ D G S L E ++K+ H Sbjct: 26 EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRI----TDIGEVSQFLTEGIIMKDFSHP 81 Query: 62 NIVRLHDV-LHSDKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 N++ L + L S+ +V + DL+ + + + + + F Q+ KG+ + S Sbjct: 82 NVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLAS 141 Query: 120 RNVLHRDLKPQNLLINRNGELKLADFGLAR--------------AFGIPVRCYSAEVVTL 165 + +HRDL +N +++ +K+ADFGLAR +PV+ + E + Sbjct: 142 KKFVHRDLAARNCMLDEKFTVKVADFGLARDMHDKEYYSVHNKTGAKLPVKWMALESLQ- 200 Query: 166 WYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEE 225 + ++T D+WS G + EL G P +P DV+ ++ L G + Sbjct: 201 ----------TQKFTTKSDVWSFGVLLWELMTRGAPPYP--DVNTFDITVYLLQGRRLLQ 248 Query: 226 QWPSMTKLPDYKPYPMY 242 P+Y P P+Y Sbjct: 249 --------PEYCPDPLY 257 >4P5Q-A nrPDB Length = 361 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 52/209 (24%), Positives = 98/209 (46%), Gaps = 12/209 (5%) Query: 10 IGEGTYGTVFKAKNR--ETHEI-VALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRL 66 +G G +G V + + EI VA+K +++ E L E ++ + H NI+RL Sbjct: 41 VGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYT-EKQRRDFLGEASIMGQFDHPNIIRL 99 Query: 67 HDVLHSDKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHR 125 V+ K + +V E+ + L + + + L + G+ + +HR Sbjct: 100 EGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYLSDMGYVHR 159 Query: 126 DLKPQNLLINRNGELKLADFGLARAF-GIPVRCYS---AEVVTLWYRPPDVLFGAKLYST 181 DL +N+LIN N K++DFGL+R P Y+ ++ W P + + + +++ Sbjct: 160 DLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIAY--RKFTS 217 Query: 182 SIDMWSAGCIFAELANAG-RPLFPGNDVD 209 + D+WS G + E+ + G RP + ++ D Sbjct: 218 ASDVWSYGIVLWEVMSYGERPYWEMSNQD 246 >3LLT-A nrPDB Length = 360 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 76/314 (24%), Positives = 137/314 (43%), Gaps = 49/314 (15%) Query: 7 LEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI--- 63 + K+G+GT+G V ++ + + A+K VR + + SA E +LK++++ +I Sbjct: 40 IRKMGDGTFGRVLLCQHIDNKKYYAVKVVR---NIKKYTRSAKIEADILKKIQNDDINNN 96 Query: 64 --VRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGD-LDPEIVKSFLFQLLKGLGFCHSR 120 V+ H + L+FE L + N + E +K + ++LK L + Sbjct: 97 NIVKYHGKFMYYDHMCLIFEPLGPSLYEIITRNNYNGFHIEDIKLYCIEILKALNYLRKM 156 Query: 121 NVLHRDLKPQNLLIN-------------------------RNGELKLADFGLARAFGIPV 155 ++ H DLKP+N+L++ ++ +KL DFG A Sbjct: 157 SLTHTDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRTKSTGIKLIDFGCAT---FKS 213 Query: 156 RCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRI 215 + + + T YR P+V+ + S DMWS GC+ AEL G LF ++ + L + Sbjct: 214 DYHGSIINTRQYRAPEVILNLG-WDVSSDMWSFGCVLAELY-TGSLLFRTHEHMEHLAMM 271 Query: 216 FRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRI 275 ++ + TK K Y L P+ NA+ + ++++ KC P+ +I Sbjct: 272 ESIIQPIPKNMLYEATKTNGSK----YVNKDELKLAWPE-NASSINSIKHVKKCLPLYKI 326 Query: 276 SAEEALQHPYFSDF 289 ++H F DF Sbjct: 327 -----IKHELFCDF 335 >4XLV-A nrPDB Length = 328 Score = 65.9 bits (159), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 56/244 (22%), Positives = 108/244 (44%), Gaps = 43/244 (17%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALRE-------ICL 54 +K L ++G+G++G V++ R+ + A RV + +E S++LRE + Sbjct: 39 EKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNE---SASLRERIEFLNEASV 95 Query: 55 LKELKHKNIVRLHDVLHSDKKLTLVFEFCDQ-DLKKYFDSCNGDLD------PEIVKSFL 107 +K ++VRL V+ + +V E DLK Y S + + P ++ + Sbjct: 96 MKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMI 155 Query: 108 ---FQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFG------------ 152 ++ G+ + +++ +HRDL +N ++ + +K+ DFG+ R Sbjct: 156 QMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGL 215 Query: 153 IPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQL 212 +PVR W P + G +++TS DMWS G + E+ + + G + L Sbjct: 216 LPVR---------WMAPESLKDG--VFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVL 264 Query: 213 KRIF 216 K + Sbjct: 265 KFVM 268 >3DKO-A nrPDB Length = 318 Score = 65.9 bits (159), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 56/225 (24%), Positives = 105/225 (46%), Gaps = 15/225 (6%) Query: 6 KLEK-IGEGTYGTVFKAKNR---ETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 K+E+ IG G +G V + + + VA+K +++ E L E ++ + H Sbjct: 46 KIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYT-EKQRRDFLCEASIMGQFDHP 104 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQD-LKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 N+V L V+ K + +V EF + L + +G + L + G+ + Sbjct: 105 NVVHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGMRYLADM 164 Query: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAF-GIPVRCYS---AEVVTLWYRPPDVLFGA 176 +HRDL +N+L+N N K++DFGL+R P Y+ ++ W P + + Sbjct: 165 GYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQY-- 222 Query: 177 KLYSTSIDMWSAGCIFAELANAG-RPLF--PGNDVDDQLKRIFRL 218 + ++++ D+WS G + E+ + G RP + DV ++ +RL Sbjct: 223 RKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRL 267 >6BSD-A nrPDB Length = 876 Score = 65.9 bits (159), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 58/241 (24%), Positives = 104/241 (43%), Gaps = 37/241 (15%) Query: 8 EKIGEGTYGTV---------------FKAKNRETHEIVALKRVRLDDDDEGVPSSALREI 52 EK+GEG +G V F R+ H ++ ++ D + + L+E+ Sbjct: 577 EKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEV 636 Query: 53 CLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQ-DLKKYF----------DSCNGD---- 97 ++ LK NI+RL V D L ++ ++ + DL ++ + GD Sbjct: 637 KIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAPGDGQAA 696 Query: 98 LDPEIVKSFLF----QLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAF-- 151 P I L Q+ G+ + + N +HRDL +N L+ N +K+ADFG++R Sbjct: 697 QGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYA 756 Query: 152 GIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQ 211 G R V+ + + + + K ++T+ D+W+ G E+ R G D+Q Sbjct: 757 GDYYRVQGRAVLPIRWMAWECILMGK-FTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQ 815 Query: 212 L 212 + Sbjct: 816 V 816 >5U6C-A nrPDB Length = 315 Score = 65.5 bits (158), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 53/221 (23%), Positives = 98/221 (44%), Gaps = 35/221 (15%) Query: 10 IGEGTYGTVFKAKNRE---THEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRL 66 +GEG +G+V + ++ T VA+K ++LD+ + L E +K+ H N++RL Sbjct: 44 LGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVMRL 103 Query: 67 HDVL-----HSDKKLTLVFEFCDQ-DLKKYFDSCNGDLDP-----EIVKSFLFQLLKGLG 115 V K ++ F DL Y + P + + F+ + G+ Sbjct: 104 LGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGME 163 Query: 116 FCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVL-- 173 + +RN LHRDL +N ++ + + +ADFGL++ + YS + +YR + Sbjct: 164 YLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSK------KIYSGD----YYRQGRIAKM 213 Query: 174 ---------FGAKLYSTSIDMWSAGCIFAELANAGRPLFPG 205 ++Y++ D+W+ G E+A G +PG Sbjct: 214 PVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPG 254 >4X7Q-B nrPDB Length = 312 Score = 65.5 bits (158), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 57/204 (27%), Positives = 90/204 (44%), Gaps = 14/204 (6%) Query: 10 IGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSS----ALREICLLKELK----HK 61 +G+G +GTVF VA+K + + P S E+ LL ++ H Sbjct: 39 LGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHP 98 Query: 62 NIVRLHDVLHSDKKLTLVFE--FCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 ++RL D + + LV E QDL Y G L + F Q++ + CHS Sbjct: 99 GVIRLLDWFETQEGFMLVLERPLPAQDLFDYITE-KGPLGEGPSRCFFGQVVAAIQHCHS 157 Query: 120 RNVLHRDLKPQNLLIN-RNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL 178 R V+HRD+K +N+LI+ R G KL DFG + Y+ T Y PP+ + + Sbjct: 158 RGVVHRDIKDENILIDLRRGCAKLIDFGSGAL--LHDEPYTDFDGTRVYSPPEWISRHQY 215 Query: 179 YSTSIDMWSAGCIFAELANAGRPL 202 ++ +WS G + ++ P Sbjct: 216 HALPATVWSLGILLYDMVCGDIPF 239 >5TOS-A nrPDB Length = 395 Score = 65.5 bits (158), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 63/212 (29%), Positives = 98/212 (46%), Gaps = 24/212 (11%) Query: 10 IGEGTYGTVFKAKNRE---------THEIVALKRVRLDDDDEGVPSSA--LREICLLKEL 58 IGEG +G VFK E T ++A+K++ + EG L EI L +L Sbjct: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKL----NQEGFQGHREWLTEINYLGQL 128 Query: 59 KHKNIVRLHDVLHSDKKLTLVFEFCDQ-DLKKYFDSCNGDLDPE---IVKSFLFQLLKGL 114 H N+V+L D+ LV+EF + L+ + P + + KGL Sbjct: 129 SHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGL 188 Query: 115 GFCHSR--NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVV--TLWYRPP 170 F HS V++RD+K N+L++ + KL+DFGLAR + Y + V T Y P Sbjct: 189 AFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAP 248 Query: 171 DVLFGAKLYSTSIDMWSAGCIFAELANAGRPL 202 + + L + S D++S G + E+ + R L Sbjct: 249 EYMSSGHLNARS-DVYSFGVLLLEILSGKRAL 279 >1FVR-A nrPDB Length = 327 Score = 65.5 bits (158), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 54/216 (25%), Positives = 93/216 (43%), Gaps = 24/216 (11%) Query: 10 IGEGTYGTVFKAKNRET--HEIVALKRVR--LDDDDEGVPSSALREICLLKELKHKNIVR 65 IGEG +G V KA+ ++ A+KR++ DD + L +C L H NI+ Sbjct: 33 IGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGH--HPNIIN 90 Query: 66 LHDVLHSDKKLTLVFEFCDQD-----LKK-----------YFDSCNGDLDPEIVKSFLFQ 109 L L L E+ L+K +S L + + F Sbjct: 91 LLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAAD 150 Query: 110 LLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRP 169 + +G+ + + +HRDL +N+L+ N K+ADFGL+R + V+ + W Sbjct: 151 VARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAI 210 Query: 170 PDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPG 205 + + +Y+T+ D+WS G + E+ + G + G Sbjct: 211 ESLNY--SVYTTNSDVWSYGVLLWEIVSLGGTPYCG 244 >4G3E-A nrPDB Length = 352 Score = 65.1 bits (157), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 50/199 (25%), Positives = 91/199 (45%), Gaps = 14/199 (7%) Query: 9 KIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHD 68 ++G G++G V + K+++T A+K+VRL+ + E+ L IV L+ Sbjct: 81 RVGRGSFGEVHRMKDKQTGFQCAVKKVRLE-------VFRVEELVACAGLSSPRIVPLYG 133 Query: 69 VLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLK 128 + + + E + G L + +L Q L+GL + H+R +LH D+K Sbjct: 134 AVREGPWVNIFMELLEGGSLGQLIKQMGCLPEDRALYYLGQALEGLEYLHTRRILHGDVK 193 Query: 129 PQNLLINRNGE-LKLADFGLARAF---GIPVRCYSAEVV--TLWYRPPDVLFGAKLYSTS 182 N+L++ +G L DFG A G+ + + + T + P+V+ G K Sbjct: 194 ADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAPEVVMG-KPCDAK 252 Query: 183 IDMWSAGCIFAELANAGRP 201 +D+WS+ C+ + N P Sbjct: 253 VDIWSSCCMMLHMLNGCHP 271 >6CKI-A nrPDB Length = 316 Score = 65.1 bits (157), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 76/310 (24%), Positives = 130/310 (41%), Gaps = 54/310 (17%) Query: 10 IGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELK-HKNIVRLHD 68 +GEG + V N T + A+K + + + S RE+ +L + + H+N++ L + Sbjct: 21 LGEGAHARVQTCINLITSQEYAVKII--EKQPGHIRSRVFREVEMLYQCQGHRNVLELIE 78 Query: 69 VLHSDKKLTLVFE-------FCDQDLKKYFDSCNGDLDPEIVKSFLFQ-LLKGLGFCHSR 120 + + LVFE +++F+ E+ S + Q + L F H++ Sbjct: 79 FFEEEDRFYLVFEKMRGGSILSHIHKRRHFN--------ELEASVVVQDVASALDFLHNK 130 Query: 121 NVLHRDLKPQNLLI---NRNGELKLADFGLARAFGIPVRC---YSAEVVT----LWYRPP 170 + HRDLKP+N+L N+ +K+ DFGL + C + E++T Y P Sbjct: 131 GIAHRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPELLTPCGSAEYMAP 190 Query: 171 DVLFG----AKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQ 226 +V+ A +Y D+WS G I L +G P F G D G E Sbjct: 191 EVVEAFSEEASIYDKRCDLWSLGVILYILL-SGYPPFVGRCGSD--------CGWDRGEA 241 Query: 227 WPSMTKLPDYKPYPMYPATTSLVNVVP-----KLNATGRDLLQNLLKCNPVQRISAEEAL 281 P+ + ++ + P ++ +DL+ LL + QR+SA + L Sbjct: 242 CPACQNM-------LFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVL 294 Query: 282 QHPYFSDFCP 291 QHP+ P Sbjct: 295 QHPWVQGCAP 304 >5GRN-A nrPDB Length = 356 Score = 65.1 bits (157), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 59/207 (28%), Positives = 95/207 (45%), Gaps = 23/207 (11%) Query: 45 PSSALREICLLKELK---HKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGD-LDP 100 P + E C +L HKN D S KK +++ D ++K N + L Sbjct: 124 PIYIITEYCFYGDLVNYLHKN----RDSFLSHKKKSML----DSEVKNLLSDDNSEGLTL 175 Query: 101 EIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSA 160 + SF +Q+ +G+ F S+N +HRDL +N+L+ + +K+ DFGLAR S Sbjct: 176 LDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSK 235 Query: 161 EVVTL---WYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVD----DQLK 213 L W P + LY+T D+WS G + E+ + G +PG VD +++K Sbjct: 236 GSTFLPVKWMAPESIF--DNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIK 293 Query: 214 RIFRLL--GTPTEEQWPSMTKLPDYKP 238 +R+ T E + M K + +P Sbjct: 294 SGYRMAKPDHATSEVYEIMVKCWNSEP 320 >1JPA-A nrPDB Length = 312 Score = 64.7 bits (156), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 59/238 (24%), Positives = 106/238 (44%), Gaps = 39/238 (16%) Query: 6 KLEK-IGEGTYGTVFKAK-----NRETHEIVALKRVRLDDDDEGVPSSALREICLLKELK 59 K+E+ IG G +G V RE VA+K ++ E L E ++ + Sbjct: 36 KIEQVIGAGEFGEVCSGHLKLPGKREI--FVAIKTLK-SGYTEKQRRDFLSEASIMGQFD 92 Query: 60 HKNIVRLHDVLHSDKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCH 118 H N++ L V+ + ++ EF + L + +G + L + G+ + Sbjct: 93 HPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLA 152 Query: 119 SRNVLHRDLKPQNLLINRNGELKLADFGLAR-------------AFG--IPVRCYSAEVV 163 N +HRDL +N+L+N N K++DFGL+R A G IP+R Sbjct: 153 DMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIR------- 205 Query: 164 TLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAG-RPLF--PGNDVDDQLKRIFRL 218 W P + + + ++++ D+WS G + E+ + G RP + DV + +++ +RL Sbjct: 206 --WTAPEAIQY--RKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRL 259 >3BBT-B nrPDB Length = 328 Score = 64.7 bits (156), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 54/228 (23%), Positives = 110/228 (48%), Gaps = 13/228 (5%) Query: 5 EKLEKIGEGTYGTVFKAKNRETHEIVALK-RVRLDDDDEGVPSSA--LREICLLKELKHK 61 ++++ +G G +GTV+K E V + +++ ++ G ++ + E ++ + H Sbjct: 18 KRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHP 77 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQD-LKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 ++VRL V S + LV + L +Y ++ +++ ++ Q+ KG+ + R Sbjct: 78 HLVRLLGVCLS-PTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEER 136 Query: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTL---WYRPPDVLFGAK 177 ++HRDL +N+L+ +K+ DFGLAR + Y+A+ + W + + + Sbjct: 137 RLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHY--R 194 Query: 178 LYSTSIDMWSAGCIFAELAN-AGRPL--FPGNDVDDQLKRIFRLLGTP 222 ++ D+WS G EL G+P P ++ D L++ RL P Sbjct: 195 KFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPP 242 >3KUL-B nrPDB Length = 325 Score = 64.7 bits (156), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 48/185 (25%), Positives = 87/185 (47%), Gaps = 13/185 (7%) Query: 49 LREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFL 107 L E ++ + H NI+RL V+ + +V E+ + L + + +G + L Sbjct: 98 LSEASIMGQFDHPNIIRLEGVVTRGRLAMIVTEYMENGSLDTFLRTHDGQFTIMQLVGML 157 Query: 108 FQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAF-GIPVRCYS---AEVV 163 + G+ + +HRDL +N+L++ N K++DFGL+R P Y+ ++ Sbjct: 158 RGVGAGMRYLSDLGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIP 217 Query: 164 TLWYRPPDVLFGAKLYSTSIDMWSAGCIFAE-LANAGRPLF--PGNDVDDQLKRIFRL-- 218 W P + F + +S++ D+WS G + E LA RP + DV ++ +RL Sbjct: 218 IRWTAPEAIAF--RTFSSASDVWSFGVVMWEVLAYGERPYWNMTNRDVISSVEEGYRLPA 275 Query: 219 -LGTP 222 +G P Sbjct: 276 PMGCP 280 >4JLC-A nrPDB Length = 657 Score = 64.7 bits (156), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 63/217 (29%), Positives = 97/217 (44%), Gaps = 30/217 (13%) Query: 10 IGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSA-LREICLLKELKHKNIVRLHD 68 +G+G VF+ ++++T ++ A+K ++ P +RE +LK+L HKNIV+L Sbjct: 16 LGQGATANVFRGRHKKTGDLYAVKV--FNNISFLRPVDVQMREFEVLKKLNHKNIVKLFA 73 Query: 69 VLH--SDKKLTLVFEFCD-QDLKKYFDS-CNGDLDPEIVKSFLFQL---LKGLGFCHSRN 121 + + + L+ EFC L + N PE FL L + G+ Sbjct: 74 IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPE--SEFLIVLRDVVGGMNHLRENG 131 Query: 122 VLHRDLKPQNLL--INRNGE--LKLADFGLARAFGIP---VRCYSAEVVTLWYRPPDVLF 174 ++HRD+KP N++ I +G+ KL DFG AR V Y E Y PD+ Sbjct: 132 IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEE----YLHPDMYE 187 Query: 175 GA-------KLYSTSIDMWSAGCIFAELANAGRPLFP 204 A K Y ++D+WS G F A P P Sbjct: 188 RAVLRKDHQKKYGATVDLWSVGVTFYHAATGSLPFRP 224 >3NYO-A nrPDB Length = 576 Score = 64.3 bits (155), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 70/286 (24%), Positives = 124/286 (43%), Gaps = 38/286 (13%) Query: 10 IGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSS-ALREICLLKELKHKNIVRLHD 68 +G+G +G V + R T ++ A K++ + + AL E +L+++ + +V L Sbjct: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAY 251 Query: 69 VLHSDKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFLF-QLLKGLGFCHSRNVLHRD 126 + L LV + DLK + PE F ++ GL H +++RD Sbjct: 252 AYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRD 311 Query: 127 LKPQNLLINRNGELKLADFGLARAFGIPV-RCYSAEVVTLWYRPPDVLFGAKLYSTSIDM 185 LKP+N+L++ +G ++++D GL A +P + V T+ Y P+V+ + Y+ S D Sbjct: 312 LKPENILLDDHGHIRISDLGL--AVHVPEGQTIKGRVGTVGYMAPEVVKNER-YTFSPDW 368 Query: 186 WSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT 245 W+ GC+ E+ AG+ F + + + RL+ EE Sbjct: 369 WALGCLLYEMI-AGQSPFQQRKKKIKREEVERLVKEVPEE-------------------- 407 Query: 246 TSLVNVVPKLNATGRDLLQNLLKCNPVQRI-----SAEEALQHPYF 286 + + R L LL +P +R+ SA E +HP F Sbjct: 408 -----YSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLF 448 >4YHJ-A nrPDB Length = 584 Score = 64.3 bits (155), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 54/198 (27%), Positives = 97/198 (48%), Gaps = 9/198 (4%) Query: 10 IGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSS-ALREICLLKELKHKNIVRLHD 68 +G+G +G V + R T ++ A K+++ + + AL E +L++++ + +V L Sbjct: 193 LGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQSRFVVSLAY 252 Query: 69 VLHSDKKLTLVFEFCDQ-DLKKY-FDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRD 126 + L LV + DLK + ++ N D + + +L GL +++RD Sbjct: 253 AYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQRERIVYRD 312 Query: 127 LKPQNLLINRNGELKLADFGLARAF--GIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSID 184 LKP+N+L++ G ++++D GLA G VR V T+ Y P+V+ K Y+ S D Sbjct: 313 LKPENILLDDRGHIRISDLGLATEIPEGQRVR---GRVGTVGYMAPEVVNNEK-YTFSPD 368 Query: 185 MWSAGCIFAELANAGRPL 202 W GC+ E+ P Sbjct: 369 WWGLGCLIYEMIQGHSPF 386 >5U6B-A nrPDB Length = 307 Score = 64.3 bits (155), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 57/238 (23%), Positives = 106/238 (44%), Gaps = 40/238 (16%) Query: 10 IGEGTYGTVFKAKNRETHEI--VALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLH 67 +GEG +G V + + + I VA+K +++ L E +KE H N++RL Sbjct: 31 LGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLI 90 Query: 68 DVLHSDKKL------TLVFEFCDQ-DLKKYF-DSCNGD----LDPEIVKSFLFQLLKGLG 115 V + ++ F DL + S GD L +++ F+ + G+ Sbjct: 91 GVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGME 150 Query: 116 FCHSRNVLHRDLKPQNLLINRNGELKLADFGLA------------RAFGIPVRCYSAEVV 163 + ++ +HRDL +N ++N N + +ADFGL+ R +PV+ + E + Sbjct: 151 YLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESL 210 Query: 164 TLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPG---NDVDDQLKRIFRL 218 ++Y++ D+WS G E+A G+ +PG +++ D L++ RL Sbjct: 211 -----------ADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRL 257 >4Y93-A nrPDB Length = 446 Score = 64.3 bits (155), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 49/217 (22%), Positives = 99/217 (45%), Gaps = 10/217 (4%) Query: 7 LEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRL 66 L+++G G +G V K R ++ VA+K ++ E + E ++ L H+ +V+L Sbjct: 193 LKELGTGQFGVVKYGKWRGQYD-VAIKMIKEGSMSE---DEFIEEAKVMMNLSHEKLVQL 248 Query: 67 HDVLHSDKKLTLVFEFCDQD-LKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHR 125 + V + + ++ E+ L Y + + + + + + S+ LHR Sbjct: 249 YGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHR 308 Query: 126 DLKPQNLLINRNGELKLADFGLAR-AFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSID 184 DL +N L+N G +K++DFG+ R + + + P+VL +K S S D Sbjct: 309 DLAARNCLVNDQGVVKVSDFGMTRYVLDDEYTSSTGSKFPVKWASPEVLMYSKFSSKS-D 367 Query: 185 MWSAGCIFAELANAGR---PLFPGNDVDDQLKRIFRL 218 +W+ G + E+ + G+ F ++ + + + RL Sbjct: 368 IWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRL 404 >5X5O-A nrPDB Length = 310 Score = 64.3 bits (155), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 51/204 (25%), Positives = 99/204 (48%), Gaps = 24/204 (11%) Query: 7 LEKIGEGTYGTVFKAKNRETHEIVALKRV-RLDDDDEGVPSSALREICLLKELKHKNIVR 65 E G G++G+V++AK + VA+K++ +++ + E +L L H+NI++ Sbjct: 20 FENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAE-----------ILSVLSHRNIIQ 68 Query: 66 LHDVLHSDKKLTLVFEFCDQDLKKYFDSCNG----DLDPEIVKSFLFQLLKGLGFCHSR- 120 + V+ +V E+ L +D N ++D + + ++ + KG+ + H Sbjct: 69 FYGVILEPPNYGIVTEYAS--LGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEA 126 Query: 121 --NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL 178 V+HRDLK +N++I +G LK+ DFG +R + + V T + P+V+ + Sbjct: 127 PVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTT--HMSLVGTFPWMAPEVIQSLPV 184 Query: 179 YSTSIDMWSAGCIFAELANAGRPL 202 S + D +S G + E+ P Sbjct: 185 -SETCDTYSYGVVLWEMLTREVPF 207 >2Y6O-A nrPDB Length = 291 Score = 64.3 bits (155), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 56/225 (24%), Positives = 107/225 (47%), Gaps = 15/225 (6%) Query: 6 KLEK-IGEGTYGTVFKAKNR--ETHEI-VALKRVRLDDDDEGVPSSALREICLLKELKHK 61 K+EK IG G +G V + + EI VA+K ++ D+ L E ++ + H Sbjct: 17 KIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQ-RRDFLSEASIMGQFDHP 75 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 NI+ L V+ K + ++ E+ + L + +G + L + G+ + Sbjct: 76 NIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYLSDM 135 Query: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAF-GIPVRCYS---AEVVTLWYRPPDVLFGA 176 + +HRDL +N+L+N N K++DFG++R P Y+ ++ W P + + Sbjct: 136 SYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAY-- 193 Query: 177 KLYSTSIDMWSAGCIFAELANAG-RPLF--PGNDVDDQLKRIFRL 218 + ++++ D+WS G + E+ + G RP + DV ++ +RL Sbjct: 194 RKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRL 238 >5LPV-A nrPDB Length = 296 Score = 64.3 bits (155), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 52/201 (25%), Positives = 92/201 (45%), Gaps = 13/201 (6%) Query: 10 IGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDV 69 IG G +G V+KA ++ + K + + + + E+ + ++KH+N+V L Sbjct: 25 IGSGGFGDVYKAILKDGSAVAIKKLIHVSGQGD---REFMAEMETIGKIKHRNLVPLLGY 81 Query: 70 LHSDKKLTLVFEFCD----QDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCH---SRNV 122 + LV+EF +D+ L+ + +GL F H S ++ Sbjct: 82 CKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHHNCSPHI 141 Query: 123 LHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVV--TLWYRPPDVLFGAKLYS 180 +HRD+K N+L++ N E +++DFG+AR S + T Y PP+ + + S Sbjct: 142 IHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPE-YYQSFRCS 200 Query: 181 TSIDMWSAGCIFAELANAGRP 201 T D++S G + EL RP Sbjct: 201 TKGDVYSYGVVLLELLTGKRP 221 >5LPZ-A nrPDB Length = 332 Score = 63.9 bits (154), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 52/201 (25%), Positives = 92/201 (45%), Gaps = 13/201 (6%) Query: 10 IGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDV 69 IG G +G V+KA ++ + K + + + + E+ + ++KH+N+V L Sbjct: 25 IGSGGFGDVYKAILKDGSAVAIKKLIHVSGQGD---REFMAEMETIGKIKHRNLVPLLGY 81 Query: 70 LHSDKKLTLVFEFCD----QDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCH---SRNV 122 + LV+EF +D+ L+ + +GL F H S ++ Sbjct: 82 CKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHHNCSPHI 141 Query: 123 LHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVV--TLWYRPPDVLFGAKLYS 180 +HRD+K N+L++ N E +++DFG+AR S + T Y PP+ + + S Sbjct: 142 IHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPE-YYQSFRCS 200 Query: 181 TSIDMWSAGCIFAELANAGRP 201 T D++S G + EL RP Sbjct: 201 TKGDVYSYGVVLLELLTGKRP 221 >4HZS-A nrPDB Length = 341 Score = 63.9 bits (154), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 54/218 (24%), Positives = 99/218 (45%), Gaps = 12/218 (5%) Query: 7 LEKIGEGTYGTVFKAK-NRETHEIVALKRVRLDDDDEGVPSSA---LREICLLKELKHKN 62 LEK+G+G++G V + + + + + V++ L D P + +RE+ + L H+N Sbjct: 17 LEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRN 76 Query: 63 IVRLHDVLHSDKKLTLVFEFCD-QDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN 121 ++RL+ V+ + + +V E L G + + Q+ +G+G+ S+ Sbjct: 77 LIRLYGVVLT-PPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYLESKR 135 Query: 122 VLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAE----VVTLWYRPPDVLFGAK 177 +HRDL +NLL+ +K+ DFGL RA Y + V W P + + Sbjct: 136 FIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESL--KTR 193 Query: 178 LYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRI 215 +S + D W G E+ G+ + G + L +I Sbjct: 194 TFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKI 231 >1U54-B nrPDB Length = 291 Score = 63.9 bits (154), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 54/218 (24%), Positives = 99/218 (45%), Gaps = 12/218 (5%) Query: 7 LEKIGEGTYGTVFKAK-NRETHEIVALKRVRLDDDDEGVPSSA---LREICLLKELKHKN 62 LEK+G+G++G V + + + + + V++ L D P + +RE+ + L H+N Sbjct: 23 LEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRN 82 Query: 63 IVRLHDVLHSDKKLTLVFEFCD-QDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN 121 ++RL+ V+ + + +V E L G + + Q+ +G+G+ S+ Sbjct: 83 LIRLYGVVLT-PPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYLESKR 141 Query: 122 VLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAE----VVTLWYRPPDVLFGAK 177 +HRDL +NLL+ +K+ DFGL RA Y + V W P + + Sbjct: 142 FIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESL--KTR 199 Query: 178 LYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRI 215 +S + D W G E+ G+ + G + L +I Sbjct: 200 TFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKI 237 >4EUT-A nrPDB Length = 396 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 62/216 (28%), Positives = 95/216 (43%), Gaps = 28/216 (12%) Query: 10 IGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDV 69 +G+G VF+ ++++T ++ A+K V +RE +LK+L HKNIV+L + Sbjct: 17 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPV-DVQMREFEVLKKLNHKNIVKLFAI 75 Query: 70 LH--SDKKLTLVFEFCD-QDLKKYFDS-CNGDLDPEIVKSFLFQL---LKGLGFCHSRNV 122 + + L+ EFC L + N PE FL L + G+ + Sbjct: 76 EEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPE--SEFLIVLRDVVGGMNHLRENGI 133 Query: 123 LHRDLKPQNLL--INRNGE--LKLADFGLARAFGIP---VRCYSAEVVTLWYRPPDVLFG 175 +HR++KP N++ I +G+ KL DFG AR V Y E Y PD+ Sbjct: 134 VHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEE----YLHPDMYER 189 Query: 176 A-------KLYSTSIDMWSAGCIFAELANAGRPLFP 204 A K Y ++D+WS G F A P P Sbjct: 190 AVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRP 225 >4LRM-A nrPDB Length = 334 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 61/240 (25%), Positives = 110/240 (45%), Gaps = 30/240 (12%) Query: 3 KYEKLEKIGEGTYGTVFKA----KNRETHEIVALKRVRLDDDDEGVPSSALREI------ 52 +++K++ +G G +GTV+K + + VA+K +R E A +EI Sbjct: 20 EFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELR-----EATSPKANKEILDEAYV 74 Query: 53 -CLLKELKHKNIVRLHDV-LHSDKKL-TLVFEF-CDQDLKKYFDSCNGDLDPEIVKSFLF 108 + + ++ RL + L S +L T + F C L Y ++ + + ++ Sbjct: 75 MASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGC---LLDYVREHKDNIGSQYLLNWCV 131 Query: 109 QLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAE---VVTL 165 Q+ KG+ + R ++HRDL +N+L+ +K+ DFGLA+ G + Y AE V Sbjct: 132 QIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIK 191 Query: 166 WYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLF---PGNDVDDQLKRIFRLLGTP 222 W +L ++Y+ D+WS G EL G + P +++ L++ RL P Sbjct: 192 WMALESILH--RIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPP 249 >6J5U-C nrPDB Length = 426 Score = 63.2 bits (152), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 66/248 (26%), Positives = 109/248 (43%), Gaps = 34/248 (13%) Query: 10 IGEGTYGTVFK---------AKNRETHEIVALKRVRLDDDDEGVPSSA--LREICLLKEL 58 +GEG +G VFK A + +VA+K+++ EG L E+ L +L Sbjct: 92 LGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQLK----PEGFQGHKEWLTEVNYLGQL 147 Query: 59 KHKNIVRLHDVLHSDKKLTLVFEFCDQ-DLKKY-FDSCNGDLDPEIVKSFLFQLLKGLGF 116 H N+V L + LV+EF + L+ + F L I KGL F Sbjct: 148 SHPNLVLLVGYCAEGENRLLVYEFMPKGSLENHLFRRGAQPLTWAIRMKVAVGAAKGLTF 207 Query: 117 CHS--RNVLHRDLKPQNLLINRNGELKLADFGLARA--FGIPVRCYSAEVVTLWYRPPDV 172 H V++RD K N+L++ + KL+DFGLA+A G + + T Y P+ Sbjct: 208 LHEAKSQVIYRDFKAANILLDADFNAKLSDFGLAKAGPTGDNTHVSTKVIGTHGYAAPEY 267 Query: 173 LFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDD------------QLKRIFRLLG 220 + +L + S D++S G + EL + R + N ++ +++FR++ Sbjct: 268 VATGRLTAKS-DVYSFGVVLLELISGRRAMDNSNGGNEYSLVDWATPYLGDKRKLFRIMD 326 Query: 221 TPTEEQWP 228 T Q+P Sbjct: 327 TKLGGQYP 334 >6O8B-A nrPDB Length = 665 Score = 63.2 bits (152), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 62/217 (28%), Positives = 97/217 (44%), Gaps = 30/217 (13%) Query: 10 IGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSA-LREICLLKELKHKNIVRLHD 68 +G+G VF+ ++++T ++ A+K ++ P +RE +LK+L HKNIV+L Sbjct: 23 LGQGATANVFRGRHKKTGDLFAIKV--FNNISFLRPVDVQMREFEVLKKLNHKNIVKLFA 80 Query: 69 VLH--SDKKLTLVFEFCD-QDLKKYFDS-CNGDLDPEIVKSFLFQL---LKGLGFCHSRN 121 + + + L+ EFC L + N PE FL L + G+ Sbjct: 81 IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPE--SEFLIVLRDVVGGMNHLRENG 138 Query: 122 VLHRDLKPQNLL--INRNGE--LKLADFGLARAFGIP---VRCYSAEVVTLWYRPPDVLF 174 ++HR++KP N++ I +G+ KL DFG AR V Y E Y PD+ Sbjct: 139 IVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVELYGTEE----YLHPDMYE 194 Query: 175 GA-------KLYSTSIDMWSAGCIFAELANAGRPLFP 204 A K Y ++D+WS G F A P P Sbjct: 195 RAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRP 231 >6NT9-A nrPDB Length = 742 Score = 63.2 bits (152), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 62/217 (28%), Positives = 97/217 (44%), Gaps = 30/217 (13%) Query: 10 IGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSA-LREICLLKELKHKNIVRLHD 68 +G+G VF+ ++++T ++ A+K ++ P +RE +LK+L HKNIV+L Sbjct: 15 LGQGATANVFRGRHKKTGDLFAIKV--FNNISFLRPVDVQMREFEVLKKLNHKNIVKLFA 72 Query: 69 VLH--SDKKLTLVFEFCD-QDLKKYFDS-CNGDLDPEIVKSFLFQL---LKGLGFCHSRN 121 + + + L+ EFC L + N PE FL L + G+ Sbjct: 73 IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPE--SEFLIVLRDVVGGMNHLRENG 130 Query: 122 VLHRDLKPQNLL--INRNGE--LKLADFGLARAFGIP---VRCYSAEVVTLWYRPPDVLF 174 ++HR++KP N++ I +G+ KL DFG AR V Y E Y PD+ Sbjct: 131 IVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEE----YLHPDMYE 186 Query: 175 GA-------KLYSTSIDMWSAGCIFAELANAGRPLFP 204 A K Y ++D+WS G F A P P Sbjct: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRP 223 >4IDT-A nrPDB Length = 356 Score = 63.2 bits (152), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 49/199 (24%), Positives = 90/199 (45%), Gaps = 14/199 (7%) Query: 9 KIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHD 68 ++G G++G V + ++++T A+K+VRL+ E+ L IV L+ Sbjct: 81 RLGRGSFGEVHRMEDKQTGFQCAVKKVRLE-------VFRAEELMACAGLTSPRIVPLYG 133 Query: 69 VLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLK 128 + + + E + G L + +L Q L+GL + HSR +LH D+K Sbjct: 134 AVREGPWVNIFMELLEGGSLGQLVKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVK 193 Query: 129 PQNLLINRNG-ELKLADFGLARAF---GIPVRCYSAEVV--TLWYRPPDVLFGAKLYSTS 182 N+L++ +G L DFG A G+ + + + T + P+V+ G + Sbjct: 194 ADNVLLSSDGSHAALCDFGHAVCLQPDGLGKDLLTGDYIPGTETHMAPEVVLG-RSCDAK 252 Query: 183 IDMWSAGCIFAELANAGRP 201 +D+WS+ C+ + N P Sbjct: 253 VDVWSSCCMMLHMLNGCHP 271 >3TKU-A nrPDB Length = 433 Score = 63.2 bits (152), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 53/215 (24%), Positives = 94/215 (43%), Gaps = 7/215 (3%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREIC-LLKELKH 60 + +E ++ IG G +G V K + T I A+K + + + ++ RE +L Sbjct: 90 EDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDC 149 Query: 61 KNIVRLHDVLHSDKKLTLVFEF-CDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 + I LH + L LV ++ DL L ++ + ++ +++ + H Sbjct: 150 QWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIHQ 209 Query: 120 RNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVV-TLWYRPPDVLF---- 174 + +HRD+KP N+L++ NG ++LADFG S+ V T Y P++L Sbjct: 210 LHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQAMED 269 Query: 175 GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVD 209 G Y D WS G E+ P + + V+ Sbjct: 270 GMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVE 304 >4EUU-A nrPDB Length = 319 Score = 62.8 bits (151), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 62/216 (28%), Positives = 95/216 (43%), Gaps = 28/216 (12%) Query: 10 IGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDV 69 +G+G VF+ ++++T ++ A+K V +RE +LK+L HKNIV+L + Sbjct: 17 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPV-DVQMREFEVLKKLNHKNIVKLFAI 75 Query: 70 LH--SDKKLTLVFEFCD-QDLKKYFDS-CNGDLDPEIVKSFLFQL---LKGLGFCHSRNV 122 + + L+ EFC L + N PE FL L + G+ + Sbjct: 76 EEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPE--SEFLIVLRDVVGGMNHLRENGI 133 Query: 123 LHRDLKPQNLL--INRNGE--LKLADFGLARAFGIP---VRCYSAEVVTLWYRPPDVLFG 175 +HR++KP N++ I +G+ KL DFG AR V Y E Y PD+ Sbjct: 134 VHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEE----YLHPDMYER 189 Query: 176 A-------KLYSTSIDMWSAGCIFAELANAGRPLFP 204 A K Y ++D+WS G F A P P Sbjct: 190 AVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRP 225 >2CMW-A nrPDB Length = 310 Score = 62.8 bits (151), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 59/208 (28%), Positives = 92/208 (44%), Gaps = 19/208 (9%) Query: 8 EKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH--KNIVR 65 +KIG G +G + KN T+E VA+K L+ P L E K+L + + + Sbjct: 6 KKIGCGNFGELRLGKNLYTNEYVAIK---LEPIKSRAPQLHL-EYRFYKQLGSAGEGLPQ 61 Query: 66 LHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHR 125 ++ K +V E L+ FD C+ + V QLL + + HS+N+++R Sbjct: 62 VYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYVHSKNLIYR 121 Query: 126 DLKPQNLLINRNGELK-----LADFGLARAF-------GIPVRCYSAEVVTLWYRPPDVL 173 D+KP+N LI R G K + DFGLA+ + IP R + + T Y + Sbjct: 122 DVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTH 181 Query: 174 FGAKLYSTSIDMWSAGCIFAELANAGRP 201 G K S D+ + G +F P Sbjct: 182 LG-KEQSRRDDLEALGHMFMYFLRGSLP 208 >4OW8-A nrPDB Length = 283 Score = 62.8 bits (151), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 56/211 (26%), Positives = 86/211 (40%), Gaps = 9/211 (4%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLD-DDDEGVPSSALREICLLKELKHK 61 +Y I G G V++A + VA+K ++ + D E L H Sbjct: 12 RYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHP 71 Query: 62 NIVRLHDVLHSD-----KKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGF 116 I +HD S + LV E + + G L L Q + L Sbjct: 72 GIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQI 131 Query: 117 CHSRNVLHRDLKPQNLLINRNGELKLADFGLARAF-GIPVRCYSAEVVTLWYRPPDVLFG 175 H+ ++HRD+KP N+LI G++K+ DFG+A+A PV + T Y P+ G Sbjct: 132 AHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQALG 191 Query: 176 AKLYSTSIDMWSAGCIFAELANAGRPLFPGN 206 S D++S G + E + RP F G+ Sbjct: 192 HDASPAS-DVYSLGVVGYEAVSGKRP-FAGD 220 >5C26-A nrPDB Length = 299 Score = 62.4 bits (150), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 56/229 (24%), Positives = 107/229 (46%), Gaps = 15/229 (6%) Query: 8 EKIGEGTYGTVFKAKNRETHEIVALKRVRLDDD--DEGVPSSALREICLLKELKHKNIVR 65 +++G G +GTV K + + + L ++ D + L E ++++L + IVR Sbjct: 33 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 92 Query: 66 LHDVLHSDKKLTLVFEFCDQD-LKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLH 124 + + ++ + LV E + L KY D I++ + Q+ G+ + N +H Sbjct: 93 MIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIE-LVHQVSMGMKYLEESNFVH 150 Query: 125 RDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLW---YRPPDVLFGAKLYST 181 RDL +N+L+ K++DFGL++A Y A+ W + P+ + K +S+ Sbjct: 151 RDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYK-FSS 209 Query: 182 SIDMWSAGCIFAELANAGRPLF---PGNDVDDQLKRIFRL---LGTPTE 224 D+WS G + E + G+ + G++V L++ R+ G P E Sbjct: 210 KSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE 258 >5HIE-A nrPDB Length = 302 Score = 62.4 bits (150), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 51/207 (24%), Positives = 97/207 (46%), Gaps = 14/207 (6%) Query: 8 EKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLH 67 ++IG G++GTV+K K H VA+K + + E+ +L++ +H NI+ L Sbjct: 42 QRIGSGSFGTVYKGK---WHGDVAVKMLTPQQ-----LQAFKNEVGVLRKTRHVNIL-LF 92 Query: 68 DVLHSDKKLTLVFEFCD-QDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRD 126 + +L +V ++C+ L + + + Q +G+ + H+++++HRD Sbjct: 93 MGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRD 152 Query: 127 LKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVT---LWYRPPDVLFGAKL-YSTS 182 LK N+ ++ + +K+ DFGLA + E ++ LW P + K YS Sbjct: 153 LKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQ 212 Query: 183 IDMWSAGCIFAELANAGRPLFPGNDVD 209 D+++ G + EL P N+ D Sbjct: 213 SDVYAFGIVLYELMTGQLPYSNINNRD 239 >5VC6-A nrPDB Length = 289 Score = 62.4 bits (150), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 42/147 (28%), Positives = 69/147 (46%), Gaps = 19/147 (12%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKEL-KHK 61 ++ +LEKIG G +G+VFK R I A+KR + +ALRE+ L +H Sbjct: 12 EFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHS 71 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQD-----------LKKYFDSCNGDLDPEIVKSFLFQL 110 ++VR D + + E+C+ + YF +K L Q+ Sbjct: 72 HVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAE-------LKDLLLQV 124 Query: 111 LKGLGFCHSRNVLHRDLKPQNLLINRN 137 +GL + HS +++H D+KP N+ I+R Sbjct: 125 GRGLRYIHSMSLVHMDIKPSNIFISRT 151 >3LMG-A nrPDB Length = 344 Score = 62.0 bits (149), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 59/223 (26%), Positives = 103/223 (46%), Gaps = 13/223 (5%) Query: 6 KLEKIGEGTYGTVFKAKNRETHEIVALKR-VRLDDDDEGVPS--SALREICLLKELKHKN 62 KL+ +G G +GTV K E + + +++ +D G S + + + L H + Sbjct: 35 KLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAH 94 Query: 63 IVRLHDVLHSDKKLTLVFEFCD-QDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN 121 IVRL L L LV ++ L + G L P+++ ++ Q+ KG+ + Sbjct: 95 IVRLLG-LCPGSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEHG 153 Query: 122 VLHRDLKPQNLLINRNGELKLADFGLARAFGIPVR--CYS-AEVVTLWYRPPDVLFGAKL 178 ++HR+L +N+L+ ++++ADFG+A + YS A+ W + FG Sbjct: 154 MVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHFGK-- 211 Query: 179 YSTSIDMWSAGCIFAELANAGRPLFPG---NDVDDQLKRIFRL 218 Y+ D+WS G EL G + G +V D L++ RL Sbjct: 212 YTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERL 254 >4X3F-A nrPDB Length = 337 Score = 62.0 bits (149), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 45/155 (29%), Positives = 67/155 (43%), Gaps = 8/155 (5%) Query: 58 LKHKNIVRLHDVLHSD-----KKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLK 112 L H I +HD S + LV E + + G L L Q + Sbjct: 69 LNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGR 128 Query: 113 GLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAF-GIPVRCYSAEVVTLWYRPPD 171 L H+ ++HRD+KP N+LI G++K+ DFG+A+A PV + T Y P+ Sbjct: 129 ALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPE 188 Query: 172 VLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGN 206 G S D++S G + E + RP F G+ Sbjct: 189 QALGHDASPAS-DVYSLGVVGYEAVSGKRP-FAGD 221 >6B2Q-A nrPDB Length = 317 Score = 62.0 bits (149), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 56/211 (26%), Positives = 86/211 (40%), Gaps = 9/211 (4%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLD-DDDEGVPSSALREICLLKELKHK 61 +Y I G G V++A + VA+K ++ + D E L H Sbjct: 33 RYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHP 92 Query: 62 NIVRLHDVLHSD-----KKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGF 116 I +HD S + LV E + + G L L Q + L Sbjct: 93 GIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQI 152 Query: 117 CHSRNVLHRDLKPQNLLINRNGELKLADFGLARAF-GIPVRCYSAEVVTLWYRPPDVLFG 175 H+ ++HRD+KP N+LI G++K+ DFG+A+A PV + T Y P+ G Sbjct: 153 AHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQALG 212 Query: 176 AKLYSTSIDMWSAGCIFAELANAGRPLFPGN 206 S D++S G + E + RP F G+ Sbjct: 213 HDASPAS-DVYSLGVVGYEAVSGKRP-FAGD 241 >4FL3-A nrPDB Length = 635 Score = 62.0 bits (149), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 56/229 (24%), Positives = 107/229 (46%), Gaps = 15/229 (6%) Query: 8 EKIGEGTYGTVFKAKNRETHEIVALKRVRLDDD--DEGVPSSALREICLLKELKHKNIVR 65 +++G G +GTV K + + + L ++ D + L E ++++L + IVR Sbjct: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 Query: 66 LHDVLHSDKKLTLVFEFCDQD-LKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLH 124 + + ++ + LV E + L KY D I++ + Q+ G+ + N +H Sbjct: 435 MIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIE-LVHQVSMGMKYLEESNFVH 492 Query: 125 RDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLW---YRPPDVLFGAKLYST 181 RDL +N+L+ K++DFGL++A Y A+ W + P+ + K +S+ Sbjct: 493 RDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYK-FSS 551 Query: 182 SIDMWSAGCIFAELANAGRPLF---PGNDVDDQLKRIFRL---LGTPTE 224 D+WS G + E + G+ + G++V L++ R+ G P E Sbjct: 552 KSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE 600 >5WNO-A nrPDB Length = 330 Score = 61.6 bits (148), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 49/213 (23%), Positives = 95/213 (44%), Gaps = 18/213 (8%) Query: 8 EKIGEGTYGTVF-------KAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 +K+G G +GTVF +AKN + VA+K + D+ L E + L+H Sbjct: 28 KKLGAGAFGTVFAGIYYPKRAKNVKIP--VAIKVFQ---TDQSQTDEMLEEATNMFRLRH 82 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCD-QDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 N++++ D L +V + +L+ + +L + +Q+ G+ + Sbjct: 83 DNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKENLGAREQVLYCYQIASGMQYLEK 142 Query: 120 RNVLHRDLKPQNLLINRNGELKLADFGLARAF---GIPVRCYSAEVVTLWYRPPDVLFGA 176 + V+HRDL +N+L+ + +++ DFGL++ + S +V W +F Sbjct: 143 QRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIE--IFSK 200 Query: 177 KLYSTSIDMWSAGCIFAELANAGRPLFPGNDVD 209 Y+ + D+W+ G E+ G+ + G D Sbjct: 201 HCYTHASDVWAFGVTCWEIITFGQSPYQGMSTD 233 >2CHL-A nrPDB Length = 351 Score = 61.6 bits (148), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 69/250 (27%), Positives = 108/250 (43%), Gaps = 28/250 (11%) Query: 8 EKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN-IVRL 66 +KIG G +G + KN T+E VA+K L+ P L E K+L + I ++ Sbjct: 36 KKIGCGNFGELRLGKNLYTNEYVAIK---LEPMKSRAPQLHL-EYRFYKQLGSGDGIPQV 91 Query: 67 HDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRD 126 + K +V E L+ FD C+ + V QL+ + + HS+N+++RD Sbjct: 92 YYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRD 151 Query: 127 LKPQNLLINRNGE-----LKLADFGLARAF-------GIPVRCYSAEVVTLWYRPPDVLF 174 +KP+N LI R G + + DF LA+ + IP R + + T Y + Sbjct: 152 VKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHL 211 Query: 175 GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLG-----TPTE---EQ 226 G K S D+ + G +F P + G D LK ++ +G TP E E Sbjct: 212 G-KEQSRRDDLEALGHMFMYFLRGSLP-WQGLKA-DTLKERYQKIGDTKRATPIEVLCEN 268 Query: 227 WPSMTKLPDY 236 +P M Y Sbjct: 269 FPEMATYLRY 278 >2OGV-A nrPDB Length = 317 Score = 60.8 bits (146), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 57/230 (24%), Positives = 101/230 (43%), Gaps = 28/230 (12%) Query: 10 IGEGTYGTVFKAK----NRETH----EIVALKRVRLDDDDEGVPSSALREICLLKEL-KH 60 +G G +G V +A +E + LK D+ E + S E+ ++ L +H Sbjct: 46 LGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMS----ELKIMSHLGQH 101 Query: 61 KNIVRLHDVLHSDKKLTLVFEFC-DQDLKKYFD-SCNGDLDPEIVK--------SFLFQL 110 +NIV L + ++ E+C DL + DLD E + F Q+ Sbjct: 102 ENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEADLDKEDGRPLELRDLLHFSSQV 161 Query: 111 LKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAF---GIPVRCYSAEVVTLWY 167 +G+ F S+N +HRD+ +N+L+ K+ DFGLAR + +A + W Sbjct: 162 AQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWM 221 Query: 168 RPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFR 217 P + +Y+ D+WS G + E+ + G +PG V+ + ++ + Sbjct: 222 APESIF--DCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVK 269 >4NEU-A nrPDB Length = 333 Score = 60.8 bits (146), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 27/100 (27%), Positives = 57/100 (57%) Query: 49 LREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLF 108 L E ++ L+H +V+L V+ + K +LV E+ ++ + + + Sbjct: 70 LEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIIL 129 Query: 109 QLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLA 148 ++++G+ + H + V+H+DLKP+N+L++ + +K+AD GLA Sbjct: 130 EIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLA 169 >4Y83-A nrPDB Length = 332 Score = 60.8 bits (146), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 67/275 (24%), Positives = 118/275 (42%), Gaps = 34/275 (12%) Query: 10 IGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDV 69 I G +G V+ A++ +T + +A K + +D + PS + C +H+NI L+ Sbjct: 81 IPRGAFGKVYLAQDIKTKKRMACKLIPVD---QFKPSDVEIQACF----RHENIAELYGA 133 Query: 70 LHSDKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLK 128 + + + L E + + + +SC + EI+ +LKGL F HS+ V+H D+K Sbjct: 134 VLWGETVHLFMEAGEGGSVLEKLESCGPMREFEII-WVTKHVLKGLDFLHSKKVIHHDIK 192 Query: 129 PQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSA 188 P N++ + L DFGL+ V T Y P+V+ + +ST D++S Sbjct: 193 PSNIVFMSTKAV-LVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVIL-CRGHSTKADIYSL 250 Query: 189 GCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSL 248 G + P +KR R + P Y Y ++ L Sbjct: 251 GATLIHMQTGTPPW---------VKRYPR-------------SAYPSYL-YIIHKQAPPL 287 Query: 249 VNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQH 283 ++ + R+L++ L+ NP R A + L+H Sbjct: 288 EDIADDCSPGMRELIEASLERNPNHRPRAADLLKH 322 >4GS6-A nrPDB Length = 315 Score = 60.8 bits (146), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 57/210 (27%), Positives = 95/210 (45%), Gaps = 23/210 (10%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 ++ E E +G G +G V KAK R VA+K++ + + + + E+ L + H Sbjct: 9 KEIEVEEVVGRGAFGVVCKAKWRAKD--VAIKQIESESERKAF----IVELRQLSRVNHP 62 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGD-----LDPEIVKSFLFQLLKGLGF 116 NIV+L+ + + LV E+ + ++ +G S+ Q +G+ + Sbjct: 63 NIVKLYGACLN--PVCLVMEYAEGG--SLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAY 118 Query: 117 CHS---RNVLHRDLKPQNLLINRNGE-LKLADFGLARAFGIPVRCYSAEVVTLWYRPPDV 172 HS + ++HRDLKP NLL+ G LK+ DFG A I + + W P Sbjct: 119 LHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFG--TACDIQTHMTNNKGSAAWMAPE-- 174 Query: 173 LFGAKLYSTSIDMWSAGCIFAELANAGRPL 202 +F YS D++S G I E+ +P Sbjct: 175 VFEGSNYSEKCDVFSWGIILWEVITRRKPF 204 >4F0G-A nrPDB Length = 287 Score = 60.8 bits (146), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 49/213 (23%), Positives = 94/213 (44%), Gaps = 19/213 (8%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVP-----SSALREICLLKE 57 +YEK +IG+G +G V K + + +VA+K + L D + RE+ ++ Sbjct: 22 EYEK--QIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQREVFIMSN 79 Query: 58 LKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFC 117 L H NIV+L+ ++H+ ++ + F C + D + + + + + G+ + Sbjct: 80 LNHPNIVKLYGLMHNPPRMVMEFVPCGDLYHRLLDKAH-PIKWSVKLRLMLDIALGIEYM 138 Query: 118 HSRN--VLHRDLKPQNLLINRNGE-----LKLADFGLARAFGIPVRCYSAEVVTL-WYRP 169 ++N ++HRDL+ N+ + E K+ADFGL++ V S + W P Sbjct: 139 QNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQ---SVHSVSGLLGNFQWMAP 195 Query: 170 PDVLFGAKLYSTSIDMWSAGCIFAELANAGRPL 202 + + Y+ D +S I + P Sbjct: 196 ETIGAEEESYTEKADTYSFAMILYTILTGEGPF 228 >3BEA-A nrPDB Length = 333 Score = 60.5 bits (145), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 56/236 (23%), Positives = 101/236 (42%), Gaps = 32/236 (13%) Query: 8 EKIGEGTYGTVFKAK----NRETH----EIVALKRVRLDDDDEGVPSSALREICLLKEL- 58 + +G G +G V +A +E + LK D+ E + S E+ ++ L Sbjct: 52 KTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMS----ELKIMSHLG 107 Query: 59 KHKNIVRLHDVLHSDKKLTLVFEFC-DQDLKKY-------------FDSCNGDLDPEIVK 104 +H+NIV L + ++ E+C DL + F N L + Sbjct: 108 QHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKSRVLETDPAFAIANSTLSTRDLL 167 Query: 105 SFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAF---GIPVRCYSAE 161 F Q+ +G+ F S+N +HRD+ +N+L+ K+ DFGLAR + +A Sbjct: 168 HFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNAR 227 Query: 162 VVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFR 217 + W P + +Y+ D+WS G + E+ + G +PG V+ + ++ + Sbjct: 228 LPVKWMAPESIF--DCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVK 281 >3I81-A nrPDB Length = 315 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 48/223 (21%), Positives = 95/223 (42%), Gaps = 37/223 (16%) Query: 9 KIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSA----LREICLLKELKHKNIV 64 ++G+G++G V++ + + RV + +E L E ++KE ++V Sbjct: 25 ELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVV 84 Query: 65 RLHDVLHSDKKLTLVFEFCDQ-DLKKYFDSCNGDLD-------PEIVKSFLF--QLLKGL 114 RL V+ + ++ E + DLK Y S +++ P + K ++ G+ Sbjct: 85 RLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMAGEIADGM 144 Query: 115 GFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFG------------IPVRCYSAEV 162 + ++ +HRDL +N ++ + +K+ DFG+ R +PVR Sbjct: 145 AYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVR------ 198 Query: 163 VTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPG 205 W P + G +++T D+WS G + E+A + G Sbjct: 199 ---WMSPESLKDG--VFTTYSDVWSFGVVLWEIATLAEQPYQG 236 >4RT7-A nrPDB Length = 415 Score = 59.7 bits (143), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 45/156 (28%), Positives = 74/156 (47%), Gaps = 15/156 (9%) Query: 106 FLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAF----GIPVRCYSAE 161 F +Q+ KG+ F ++ +HRDL +N+L+ +K+ DFGLAR VR +A Sbjct: 248 FAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRG-NAR 306 Query: 162 VVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFR---L 218 + W P + G +Y+ D+WS G + E+ + G +PG VD ++ + Sbjct: 307 LPVKWMAPESLFEG--IYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFK 364 Query: 219 LGTP---TEEQWPSMTKLP--DYKPYPMYPATTSLV 249 + P TEE + M D + P +P TS + Sbjct: 365 MDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFL 400 Score = 28.9 bits (63), Expect = 3.0, Method: Compositional matrix adjust. Identities = 24/95 (25%), Positives = 41/95 (43%), Gaps = 17/95 (17%) Query: 10 IGEGTYGTVFKAKNRETHEI-----VALKRVRLDDDDEGVPSSALREICLLKEL-KHKNI 63 +G G +G V A + VA+K ++ + D + + E+ ++ +L H+NI Sbjct: 73 LGSGAFGKVMNATAYGISKTGVSIQVAVKMLK-EKADSSEREALMSELKMMTQLGSHENI 131 Query: 64 VRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDL 98 V L + L+FE+C C GDL Sbjct: 132 VNLLGACTLSGPIYLIFEYC----------CYGDL 156 >2HW6-A nrPDB Length = 307 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 72/303 (23%), Positives = 119/303 (39%), Gaps = 36/303 (11%) Query: 8 EKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELK-HKNIVRL 66 E +GEG Y V A + + + A+K + S RE+ L + + +KNI+ L Sbjct: 19 ELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHS--RSRVFREVETLYQCQGNKNILEL 76 Query: 67 HDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRD 126 + D + LVFE + + + L F H++ + HRD Sbjct: 77 IEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKGIAHRD 136 Query: 127 LKPQNLLI---NRNGELKLADFGLARAFGIPVRC---YSAEVVT----LWYRPPDVLF-- 174 LKP+N+L + +K+ DF L + C + E+ T Y P+V+ Sbjct: 137 LKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVF 196 Query: 175 --GAKLYSTSIDMWSAGCIFAELANAGRPLFPGN---DVDDQLKRIFRLLGTPT-EEQWP 228 A Y D+WS G + + +G P F G+ D + R+ E Sbjct: 197 TDQATFYDKRCDLWSLGVVLY-IMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQE 255 Query: 229 SMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288 + PD K + +++ +DL+ LL + QR+SA + LQHP+ Sbjct: 256 GKYEFPD-KDW-------------AHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQG 301 Query: 289 FCP 291 P Sbjct: 302 QAP 304 >5UIU-A nrPDB Length = 323 Score = 59.3 bits (142), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 53/193 (27%), Positives = 85/193 (44%), Gaps = 9/193 (4%) Query: 9 KIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHD 68 K+GEG +G V+K T V +D E + +EI ++ + +H+N+V L Sbjct: 54 KMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLG 113 Query: 69 VLHSDKKLTLVFEFC-DQDLKKYFDSCNGD--LDPEIVKSFLFQLLKGLGFCHSRNVLHR 125 L LV+ + + L +G L + G+ F H + +HR Sbjct: 114 FSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHR 173 Query: 126 DLKPQNLLINRNGELKLADFGLARA---FGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTS 182 D+K N+L++ K++DFGLARA F V S V T Y P+ L G + Sbjct: 174 DIKSANILLDEAFTAKISDFGLARASEKFAQTVMT-SRIVGTTAYMAPEALRGE--ITPK 230 Query: 183 IDMWSAGCIFAEL 195 D++S G + E+ Sbjct: 231 SDIYSFGVVLLEI 243 >2C47-A nrPDB Length = 313 Score = 58.9 bits (141), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 54/207 (26%), Positives = 92/207 (44%), Gaps = 18/207 (8%) Query: 8 EKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH-KNIVRL 66 +KIG G +G + KN T+E VA+K L+ P L E K+L + + ++ Sbjct: 10 KKIGCGNFGELRLGKNLYTNEYVAIK---LEPIKSRAPQLHL-EYRFYKQLSATEGVPQV 65 Query: 67 HDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRD 126 + K +V E L+ FD C+ + V QL+ + + H++++++RD Sbjct: 66 YYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYVHTKSLIYRD 125 Query: 127 LKPQNLLINRNG-----ELKLADFGLARAF-------GIPVRCYSAEVVTLWYRPPDVLF 174 +KP+N L+ R G + + DFGLA+ + IP R + + T Y + Sbjct: 126 VKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHL 185 Query: 175 GAKLYSTSIDMWSAGCIFAELANAGRP 201 G K S D+ + G +F P Sbjct: 186 G-KEQSRRDDLEALGHMFMYFLRGSLP 211 >4M66-A nrPDB Length = 325 Score = 58.5 bits (140), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 64/218 (29%), Positives = 102/218 (46%), Gaps = 33/218 (15%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 ++ +KLE +G+G +G VF+A +R + VA+K V E+ + L+++ Sbjct: 20 EELKKLEFVGKGGFGVVFRAHHRTWNHDVAVKIVN--------SKKISWEVKAMVNLRNE 71 Query: 62 NIVRLHDVLHSDKKLTLVFEFCD-QDLKKYF---DSCNGDLDPEIVKSF------LFQLL 111 N++ L V L ++F Q L F S G L PE + + L +++ Sbjct: 72 NVLLLLGVTED-----LQWDFVSGQALVTRFMENGSLAGLLQPEAPRPWPLLCRLLQEVV 126 Query: 112 KGLGFCHSRN--VLHRDLKPQNLLINRNGELKLADFGLAR------AFGIPVRCYSAEVV 163 G+ + HS + +LHRDLKP N+L++ KLADFGL+ + Sbjct: 127 LGMCYLHSLDPPLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQSGSGSGSGSRDSGG 186 Query: 164 TLWYRPPDVLFGAKL-YSTSIDMWSAGCIFAELANAGR 200 TL Y P++LF L S + D++S G I AGR Sbjct: 187 TLAYLDPELLFKVNLKASKASDVYSFG-ILVWAVLAGR 223 >6BXI-A nrPDB Length = 333 Score = 58.2 bits (139), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 40/148 (27%), Positives = 69/148 (46%), Gaps = 1/148 (0%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALR-EICLLKELK 59 ++ +E L+ IG G +G V + ++T + A+K +R D E +R E +L E Sbjct: 5 LEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEAD 64 Query: 60 HKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 +V++ L L+ EF L E + ++ + + + H Sbjct: 65 SLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQ 124 Query: 120 RNVLHRDLKPQNLLINRNGELKLADFGL 147 +HRD+KP NLL++ G +KL+DFGL Sbjct: 125 LGFIHRDIKPDNLLLDSKGHVKLSDFGL 152 >3KRL-A nrPDB Length = 335 Score = 58.2 bits (139), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 57/236 (24%), Positives = 102/236 (43%), Gaps = 34/236 (14%) Query: 10 IGEGTYGTVFKAK----NRETH----EIVALKRVRLDDDDEGVPSSALREICLLKEL-KH 60 +G G +G V +A +E + LK D+ E + + E+ ++ L +H Sbjct: 54 LGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEAL----MSELKIMSHLGQH 109 Query: 61 KNIVRLHDVLHSDKKLTLVFEFC-DQDLKKYFD---------SCNGDLDPEIVKS----- 105 +NIV L + ++ E+C DL + S N +PE S Sbjct: 110 ENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKRPPGLEYSYNPSHNPEEQLSSRDLL 169 Query: 106 -FLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAF---GIPVRCYSAE 161 F Q+ +G+ F S+N +HRD+ +N+L+ K+ DFGLAR + +A Sbjct: 170 HFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNAR 229 Query: 162 VVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFR 217 + W P + +Y+ D+WS G + E+ + G +PG V+ + ++ + Sbjct: 230 LPVKWMAPESIF--DCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVK 283 >5TE0-A nrPDB Length = 347 Score = 57.8 bits (138), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 59/216 (27%), Positives = 106/216 (49%), Gaps = 38/216 (17%) Query: 8 EKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELK-HKNIV-- 64 E + EG + VF + + ALKR+ ++++ + REI ++++L HKNIV Sbjct: 25 EVLAEGGFAIVFLVRTSNGMK-CALKRMFVNNEHD--LQVCKREIQIMRDLSGHKNIVGY 81 Query: 65 ---RLHDVLHSDK-KLTLVFEFC---------DQDLKKYFDSCNGDLDPEIVKSFL--FQ 109 +++V D ++ ++ +FC +Q L+ F + E+++ F + Sbjct: 82 IDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFT------ENEVLQIFCDTCE 135 Query: 110 LLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLA-RAFGIP----VRCYSAEV-- 162 + L C + ++HRDLK +N+L++ G L DFG A F P V E+ Sbjct: 136 AVARLHQCKTP-IIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKK 194 Query: 163 -VTLWYRPPDV--LFGAKLYSTSIDMWSAGCIFAEL 195 TL YR P++ L+ K+ +T D+W+ GC+ +L Sbjct: 195 YTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKL 230 >6BFN-A nrPDB Length = 342 Score = 57.8 bits (138), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 46/149 (30%), Positives = 69/149 (46%), Gaps = 10/149 (6%) Query: 9 KIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDE--GVPSSALREICLLKELKHKNIVRL 66 KIGEG +G V++A R T + A+KR++ + D E V S L E+ L +H NIV Sbjct: 29 KIGEGGFGCVYRAVMRNT--VYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDF 86 Query: 67 HDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIV----KSFLFQLLKGLGFCH--SR 120 + LV+ F + C P + L + + F H S Sbjct: 87 AGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSP 146 Query: 121 NVLHRDLKPQNLLINRNGELKLADFGLAR 149 +++H D+K N+L++ KL DFGLAR Sbjct: 147 SLIHGDIKSSNVLLDERLTPKLGDFGLAR 175 >5VDK-A nrPDB Length = 297 Score = 57.8 bits (138), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 42/142 (29%), Positives = 71/142 (50%), Gaps = 11/142 (7%) Query: 3 KYEK----LEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKEL 58 +YEK +EKIG G +GTV+K R + A+KR + +SAL E+ L Sbjct: 12 RYEKEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSALHEVYAHAVL 71 Query: 59 KHK-NIVRLHDVLHSDKKLTLVFEFCDQD-----LKKYFDSCNGDLDPEIVKSFLFQLLK 112 H ++VR + D + + E+C+ + + S N +P++ K L Q+ Sbjct: 72 GHHPHVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKL-KDILLQISL 130 Query: 113 GLGFCHSRNVLHRDLKPQNLLI 134 GL + H+ +++H D+KP N+ I Sbjct: 131 GLNYIHNSSMVHLDIKPSNIFI 152 >4R7H-A nrPDB Length = 343 Score = 57.8 bits (138), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 56/243 (23%), Positives = 102/243 (41%), Gaps = 41/243 (16%) Query: 10 IGEGTYGTVFKAK----NRETH----EIVALKRVRLDDDDEGVPSSALREICLLKEL-KH 60 +G G +G V +A +E + LK D+ E + + E+ ++ L +H Sbjct: 58 LGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEAL----MSELKIMSHLGQH 113 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCD-QDLKKYFD---------SCNGDLDPEIVKS----- 105 +NIV L + ++ E+C DL + S + DPE + Sbjct: 114 ENIVNLLGACTHGGPVLVITEYCTYGDLLNFLRRKAEAMLGPSLSPGQDPEGLDKEDGRP 173 Query: 106 --------FLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAF---GIP 154 F Q+ +G+ F S+N +HRD+ +N+L+ K+ DFGLAR Sbjct: 174 LELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNY 233 Query: 155 VRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKR 214 + +A + W P + +Y+ D+WS G + E+ + G +PG V+ + + Sbjct: 234 IVKGNARLPVKWMAPESIF--DSVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYK 291 Query: 215 IFR 217 + + Sbjct: 292 LVK 294 >2QKW-B nrPDB Length = 321 Score = 56.6 bits (135), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 53/195 (27%), Positives = 98/195 (50%), Gaps = 16/195 (8%) Query: 10 IGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDV 69 IG G +G V+K R+ + VALKR R + +G+ L +H ++V L Sbjct: 47 IGHGVFGKVYKGVLRDGAK-VALKR-RTPESSQGIEEFETEIE-TLSFCRHPHLVSLIGF 103 Query: 70 LHSDKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFLFQL------LKGLGFCHSRNV 122 ++ L++++ + +LK++ DL P + S+ +L +GL + H+R + Sbjct: 104 CDERNEMILIYKYMENGNLKRHL--YGSDL-PTMSMSWEQRLEICIGAARGLHYLHTRAI 160 Query: 123 LHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVV--TLWYRPPDVLFGAKLYS 180 +HRD+K N+L++ N K+ DFG+++ + + + VV TL Y P+ +L Sbjct: 161 IHRDVKSINILLDENFVPKITDFGISKKGTELDQTHLSTVVKGTLGYIDPEYFIKGRLTE 220 Query: 181 TSIDMWSAGCIFAEL 195 S D++S G + E+ Sbjct: 221 KS-DVYSFGVVLFEV 234 >3G2F-A nrPDB Length = 336 Score = 56.6 bits (135), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 61/234 (26%), Positives = 96/234 (41%), Gaps = 42/234 (17%) Query: 7 LEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRL 66 LE IG G YG V+K E VA+K + + + + L++ H NI R Sbjct: 18 LELIGRGRYGAVYKGSLDE--RPVAVKVFSFANRQNFINEKNIYRVPLME---HDNIARF 72 Query: 67 HDVLHSDKKLT--------LVFEFC-DQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFC 117 + D+++T LV E+ + L KY D + +GL + Sbjct: 73 ---IVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSC--RLAHSVTRGLAYL 127 Query: 118 HSR---------NVLHRDLKPQNLLINRNGELKLADFGLARAF--------GIPVRCYSA 160 H+ + HRDL +N+L+ +G ++DFGL+ G + Sbjct: 128 HTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPGEEDNAAIS 187 Query: 161 EVVTLWYRPPDVLFGA------KLYSTSIDMWSAGCIFAELANAGRPLFPGNDV 208 EV T+ Y P+VL GA + +DM++ G I+ E+ LFPG V Sbjct: 188 EVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESV 241 >3PP0-A nrPDB Length = 338 Score = 56.2 bits (134), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 57/224 (25%), Positives = 102/224 (45%), Gaps = 15/224 (6%) Query: 6 KLEKIGEGTYGTVFKA---KNRETHEI-VALKRVRLDDDDEGVPSSALREICLLKELKHK 61 K++ +G G +GTV+K + E +I VA+K +R ++ L E ++ + Sbjct: 21 KVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLR-ENTSPKANKEILDEAYVMAGVGSP 79 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQD-LKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 + RL + + + LV + L + G L + + ++ Q+ KG+ + Sbjct: 80 YVSRLLGICLT-STVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDV 138 Query: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAE---VVTLWYRPPDVLFGAK 177 ++HRDL +N+L+ +K+ DFGLAR I Y A+ V W +L + Sbjct: 139 RLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESIL--RR 196 Query: 178 LYSTSIDMWSAGCIFAELANAG-RPL--FPGNDVDDQLKRIFRL 218 ++ D+WS G EL G +P P ++ D L++ RL Sbjct: 197 RFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERL 240 >3QUP-A nrPDB Length = 323 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 54/221 (24%), Positives = 100/221 (45%), Gaps = 18/221 (8%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRE---THEIVALKRVRLDDDDEGVPSSALREICLLKEL 58 Q++ +G+G +G+V +A+ ++ + VA+K ++ D LRE +KE Sbjct: 23 QQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEF 82 Query: 59 KHKNIVRLHDV-LHSDKKLTL-----VFEFCDQ-DLKKYFDSCNGDLDP-----EIVKSF 106 H ++ +L V L S K L + F DL + + +P + + F Sbjct: 83 DHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLVRF 142 Query: 107 LFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAF--GIPVRCYSAEVVT 164 + + G+ + SRN +HRDL +N ++ + + +ADFGL+R G R A + Sbjct: 143 MVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLP 202 Query: 165 LWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPG 205 + + + L LY+ D+W+ G E+ G+ + G Sbjct: 203 VKWLALESL-ADNLYTVHSDVWAFGVTMWEIMTRGQTPYAG 242 >2BUJ-A nrPDB Length = 317 Score = 55.8 bits (133), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 53/212 (25%), Positives = 93/212 (43%), Gaps = 25/212 (11%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 + Y ++K+GEG + V + ALKR+ + + A RE + + H Sbjct: 29 KHYLFIQKLGEGGFSYVDLVEGLHDGHFYALKRILCHEQQD--REEAQREADMHRLFNHP 86 Query: 62 NIVRLHDVLHSDK----KLTLVFEFCDQ-----DLKKYFDSCNGDLDPEIVKSFLFQLLK 112 NI+RL ++ + L+ F + ++++ D N + +I+ L + + Sbjct: 87 NILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFLTEDQIL-WLLLGICR 145 Query: 113 GLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRC---------YSAEVV 163 GL H++ HRDLKP N+L+ G+ L D G I V ++A+ Sbjct: 146 GLEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSRQALTLQDWAAQRC 205 Query: 164 TLWYRPPDVLFGAKLYST---SIDMWSAGCIF 192 T+ YR P+ LF + + D+WS GC+ Sbjct: 206 TISYRAPE-LFSVQSHCVIDERTDVWSLGCVL 236 >3SV0-A nrPDB Length = 483 Score = 55.5 bits (132), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 46/155 (29%), Positives = 77/155 (49%), Gaps = 12/155 (7%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62 K+ KIG G++G ++ N +T+E VA+K L++ P L E + + L+ Sbjct: 8 KFRLGRKIGSGSFGEIYLGTNIQTNEEVAIK---LENVKTKHPQ-LLYESKIYRILQGGT 63 Query: 63 I---VRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 VR V D + LV + L+ F+ C+ L + V Q++ + F HS Sbjct: 64 GIPNVRWFGV-EGDYNV-LVMDLLGPSLEDLFNFCSRKLSLKTVLMLADQMINRVEFVHS 121 Query: 120 RNVLHRDLKPQNLLIN---RNGELKLADFGLARAF 151 ++ LHRD+KP N L+ R ++ + DFGLA+ + Sbjct: 122 KSFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKY 156 >3QD2-B nrPDB Length = 332 Score = 55.5 bits (132), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 32/102 (31%), Positives = 50/102 (49%), Gaps = 13/102 (12%) Query: 106 FLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFG---------IPVR 156 Q+ + + F HS+ ++HRDLKP N+ + +K+ DFGL A P+ Sbjct: 169 IFIQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMP 228 Query: 157 CY---SAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAEL 195 Y + +V T Y P+ + G YS +D++S G I EL Sbjct: 229 AYATHTGQVGTKLYMSPEQIHGNN-YSHKVDIFSLGLILFEL 269 Score = 42.0 bits (97), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 23/62 (37%), Positives = 37/62 (59%), Gaps = 1/62 (1%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 +E ++ +G G +G VF+AKN+ A+KR+RL + E +RE+ L +L+H I Sbjct: 8 FEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRL-PNRELAREKVMREVKALAKLEHPGI 66 Query: 64 VR 65 VR Sbjct: 67 VR 68 >5XD6-A nrPDB Length = 305 Score = 54.7 bits (130), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 54/207 (26%), Positives = 96/207 (46%), Gaps = 19/207 (9%) Query: 10 IGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDV 69 IGEG+YG VF + + + A+K++ D + L ++ ++ L+ +N+V L Sbjct: 30 IGEGSYGRVFYGILK-SGKAAAIKKL---DSSKQPDQEFLAQVSMVSRLRQENVVALLGY 85 Query: 70 LHSDKKLTLVFEFC-DQDLKKYFDSCNG--DLDPEIVKSFLFQL------LKGLGFCHSR 120 L +E+ + L G P V S+ ++ +GL + H + Sbjct: 86 CVDGPLRVLAYEYAPNGSLHDILHGRKGVKGAQPGPVLSWHQRVKIAVGAARGLEYLHEK 145 Query: 121 ---NVLHRDLKPQNLLINRNGELKLADFGLA-RAFGIPVRCYSAEVV-TLWYRPPDVLFG 175 +V+HRD+K N+L+ + K+ADF L+ +A + R +S V+ T Y P+ Sbjct: 146 ANPHVIHRDIKSSNVLLFDDDVAKIADFDLSNQAPDMAARLHSTRVLGTFGYHAPEYAMT 205 Query: 176 AKLYSTSIDMWSAGCIFAELANAGRPL 202 L ST D++S G + EL +P+ Sbjct: 206 GTL-STKSDVYSFGVVLLELLTGRKPV 231 >5FQD-C nrPDB Length = 341 Score = 54.7 bits (130), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 47/159 (29%), Positives = 76/159 (47%), Gaps = 20/159 (12%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62 KY+ + KIG G++G ++ A N E VA+K + S R LL E K Sbjct: 20 KYKLVRKIGSGSFGDIYLAINITNGEEVAVK----------LESQKARHPQLLYESKLYK 69 Query: 63 IVRL-----HDVLHSDKK--LTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLG 115 I++ H + +K LV + L+ F+ C+ + V Q++ + Sbjct: 70 ILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIE 129 Query: 116 FCHSRNVLHRDLKPQNLL--INRN-GELKLADFGLARAF 151 + H++N +HRD+KP N L I R+ +L L DFGLA+ + Sbjct: 130 YVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKY 168 >4OTD-A nrPDB Length = 341 Score = 54.7 bits (130), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 72/305 (23%), Positives = 126/305 (41%), Gaps = 61/305 (20%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDD----DDEGVPSSALREICLLK 56 ++ ++ L +G G +G V ++ R + E+ A+K ++ D D+ R + + Sbjct: 11 LEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVT 70 Query: 57 ELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQ------- 109 H +V L + + + V E+ S GDL I + Sbjct: 71 SAGHPFLVNLFGCFQTPEHVCFVMEY----------SAGGDLMLHIHSDVFSEPRAIFYS 120 Query: 110 --LLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLAR-AFGIPVRCYSAEVVTLW 166 ++ GL F H +++RDLK NLL++ G +K+ADFGL + G R S T Sbjct: 121 ACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRT-STFCGTPE 179 Query: 167 YRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQ 226 + P+VL Y+ ++D W G + E+ P FPG+D ++ I Sbjct: 180 FLAPEVLTDTS-YTRAVDWWGLGVLLYEMLVGESP-FPGDDEEEVFDSI----------- 226 Query: 227 WPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRIS-----AEEAL 281 + D YP + L+A +++ LL+ NP +R+ AE+ Sbjct: 227 ------VNDEVRYPRF------------LSAEAIGIMRRLLRRNPERRLGSSERDAEDVK 268 Query: 282 QHPYF 286 + P+F Sbjct: 269 KQPFF 273 >3MDY-A nrPDB Length = 337 Score = 53.5 bits (127), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 60/220 (27%), Positives = 101/220 (45%), Gaps = 35/220 (15%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 ++ + +++IG+G YG V+ K R E VA+K ++ + + + L++ H+ Sbjct: 37 KQIQMVKQIGKGRYGEVWMGKWR--GEKVAVKVFFTTEEASWFRETEIYQTVLMR---HE 91 Query: 62 NIVRL--HDV--LHSDKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFLFQLLKGLGF 116 NI+ D+ S +L L+ ++ + L Y S LD + + + + GL Sbjct: 92 NILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTT--LDAKSMLKLAYSSVSGLCH 149 Query: 117 CHSR--------NVLHRDLKPQNLLINRNGELKLADFGLARAF-------GIPVRCYSAE 161 H+ + HRDLK +N+L+ +NG +AD GLA F IP + Sbjct: 150 LHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPP---NTR 206 Query: 162 VVTLWYRPPDVL---FGAKLYSTSI--DMWSAGCIFAELA 196 V T Y PP+VL + + I DM+S G I E+A Sbjct: 207 VGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVA 246 >4JRN-A nrPDB Length = 372 Score = 53.5 bits (127), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 75/324 (23%), Positives = 123/324 (37%), Gaps = 91/324 (28%) Query: 10 IGEGTYGTVFKAKNRETHEIVALKRVRLDDD--DEGV-----PSSALREICLLKELKH-- 60 +G G + TV++A + ET+E +A+K + + DE + SS R L K K Sbjct: 76 LGSGGFATVYEATDVETNEELAVKVFMSEKEPTDETMLDLQRESSCYRNFSLAKTAKDAQ 135 Query: 61 --------KNIVRLHDVLHSDKKLT-----------LVFEFCDQDLKKYFDSCNGDLDPE 101 ++V L S + + L+ + D+ K GD Sbjct: 136 ESCRFMVPSDVVMLEGQPASTEVVIGLTTRWVPNYFLLMMRAEADMSKVISWVFGDASVN 195 Query: 102 ------IVKSFLF-QLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFG-------L 147 +V+ +L Q +K + ++ ++H D+KP N L+ ++G L L DFG + Sbjct: 196 KSEFGLVVRMYLSSQAIKLVANVQAQGIVHTDIKPANFLLLKDGRLFLGDFGTYRINNSV 255 Query: 148 ARAFGIPVRCYSAEVVTLWYRPPDVLFGAK--LYSTSIDMWSAGCIFAELANAGRPLFPG 205 RA G P Y PP+ F A Y+ D W G + RP Sbjct: 256 GRAIGTP-----------GYEPPERPFQATGITYTFPTDAWQLGITLYCIWCKERP---- 300 Query: 206 NDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQN 265 TP + W DY + P+T LV +DL+++ Sbjct: 301 ---------------TPADGIW-------DYLHFADCPSTPELV----------QDLIRS 328 Query: 266 LLKCNPVQRISAEEALQHPYFSDF 289 LL +P +R+ +AL+ F + Sbjct: 329 LLNRDPQKRMLPLQALETAAFKEM 352 >4CRS-A nrPDB Length = 341 Score = 53.5 bits (127), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 69/293 (23%), Positives = 123/293 (41%), Gaps = 61/293 (20%) Query: 13 GTYGTVFKAKNRETHEIVALKRVRLDD----DDEGVPSSALREICLLKELKHKNIVRLHD 68 G +G V A+ + T+E+ A+K ++ D D+ R + ++H +V L Sbjct: 23 GHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVNLFA 82 Query: 69 VLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQ---------LLKGLGFCHS 119 + + + V E+ + GDL I + ++ GL + H Sbjct: 83 CFQTKEHVCFVMEY----------AAGGDLMMHIHTDVFSEPRAVFYAACVVLGLQYLHE 132 Query: 120 RNVLHRDLKPQNLLINRNGELKLADFGLAR-AFGIPVRCYSAEVVTLWYRPPDVLFGAKL 178 +++RDLK NLL++ G +K+ADFGL + G R S T + P+VL Sbjct: 133 HKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRT-STFCGTPEFLAPEVLTETS- 190 Query: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKP 238 Y+ ++D W G + E+ P FPG+D ++ I + D Sbjct: 191 YTRAVDWWGLGVLIYEMLVGESP-FPGDDEEEVFDSI-----------------VNDEVR 232 Query: 239 YPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRIS-----AEEALQHPYF 286 YP + +T ++ +++ LL+ NP +R+ AE+ +HP+F Sbjct: 233 YPRFLSTEAI------------SIMRRLLRRNPERRLGASEKDAEDVKKHPFF 273 >4YFF-A nrPDB Length = 311 Score = 52.4 bits (124), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 48/208 (23%), Positives = 93/208 (44%), Gaps = 8/208 (3%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDD-DEGVPSSALREICLLKELK 59 + + E E IG G++G V+K + R ++IVA+KR R + + RE+ +L +L Sbjct: 41 LSEIEFHEIIGSGSFGKVYKGRCR--NKIVAIKRYRANTYCSKSDVDMFCREVSILCQLN 98 Query: 60 HKNIVR-LHDVLHSDKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFC 117 H +++ + L+ + +V ++ L LD + + KG+ + Sbjct: 99 HPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYL 158 Query: 118 H--SRNVLHRDLKPQNLLINRNGELKLADFGLARAF-GIPVRCYSAEVVTLWYRPPDVLF 174 H ++ ++HRDL N+L+ +G +ADFG +R + + + L + P+V Sbjct: 159 HNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFT 218 Query: 175 GAKLYSTSIDMWSAGCIFAELANAGRPL 202 Y+ D++S E+ P Sbjct: 219 QCTRYTIKADVFSYALCLWEILTGEIPF 246 >3SOC-A nrPDB Length = 322 Score = 51.6 bits (122), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 57/213 (26%), Positives = 95/213 (44%), Gaps = 30/213 (14%) Query: 7 LEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRL 66 LE G +G V+KA+ +E VA+K + D E+ L +KH+NI++ Sbjct: 29 LEVKARGRFGCVWKAQ--LLNEYVAVKIFPIQDKQSWQNE---YEVYSLPGMKHENILQF 83 Query: 67 HDVLHSDKKLTLV----------------FEFCDQDLKKYFDSCNGDLDPEIVKSFLFQL 110 + ++K+ T V +F ++ + + C+ ++L + Sbjct: 84 ---IGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHED 140 Query: 111 LKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAF--GIPVRCYSAEVVTLWYR 168 + GL H + HRD+K +N+L+ N +ADFGLA F G +V T Y Sbjct: 141 IPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYM 200 Query: 169 PPDVLFGAKLYSTS----IDMWSAGCIFAELAN 197 P+VL GA + IDM++ G + ELA+ Sbjct: 201 APEVLEGAINFQRDAFLRIDMYAMGLVLWELAS 233 >5USZ-A nrPDB Length = 289 Score = 51.6 bits (122), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 56/224 (25%), Positives = 94/224 (41%), Gaps = 22/224 (9%) Query: 8 EKIGEGTYGTVFKAKNRET------HEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 E +G+GT+ +FK RE HE L +V LD S ++ +L HK Sbjct: 14 ESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKV-LDKAHRNYSESFFEAASMMSKLSHK 72 Query: 62 NIVRLHDVLHSDKKLTLVFEFC-----DQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGF 116 ++V + V + LV EF D LKK + N E+ K QL + F Sbjct: 73 HLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAK----QLAAAMHF 128 Query: 117 CHSRNVLHRDLKPQNLLINRNGELKLAD--FGLARAFGIPVRCYSAEVVT--LWYRPPDV 172 ++H ++ +N+L+ R + K + F GI + +++ + + PP+ Sbjct: 129 LEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPEC 188 Query: 173 LFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIF 216 + K + + D WS G E+ + G P + +D Q K F Sbjct: 189 IENPKNLNLATDKWSFGTTLWEICSGGDK--PLSALDSQRKLQF 230 >2H34-A nrPDB Length = 309 Score = 50.8 bits (120), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 52/200 (26%), Positives = 89/200 (44%), Gaps = 6/200 (3%) Query: 10 IGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSAL-REICLLKELKHKNIVRLHD 68 +G G G V++A++ IVALK + + V + + RE L+ ++V +HD Sbjct: 42 VGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPVFRTRMQREARTAGRLQEPHVVPIHD 101 Query: 69 VLHSDKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDL 127 D +L + + DL G L P + + Q+ L H+ HRD+ Sbjct: 102 FGEIDGQLYVDMRLINGVDLAAMLRR-QGPLAPPRAVAIVRQIGSALDAAHAAGATHRDV 160 Query: 128 KPQNLLINRNGELKLADFGLARAFGIP-VRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMW 186 KP+N+L++ + L DFG+A A + V TL+Y P+ F + D++ Sbjct: 161 KPENILVSADDFAYLVDFGIASATTDEKLTQLGNTVGTLYYMAPE-RFSESHATYRADIY 219 Query: 187 SAGCIFAELANAGRPLFPGN 206 + C+ E G P + G+ Sbjct: 220 ALTCVLYECLT-GSPPYQGD 238 >2QLU-A nrPDB Length = 314 Score = 50.1 bits (118), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 60/216 (27%), Positives = 97/216 (44%), Gaps = 35/216 (16%) Query: 7 LEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRL 66 LE G +G V+KA+ ++ VA+K L D + REI +KH+N+++ Sbjct: 20 LEIKARGRFGCVWKAQL--MNDFVAVKIFPLQDKQSW---QSEREIFSTPGMKHENLLQF 74 Query: 67 HDVLHSDKK-------LTLVFEFCDQDLKKYFDSCNGDLD--------PEIVKSFLFQLL 111 + ++K+ L L+ F D+ D G++ E + L L Sbjct: 75 ---IAAEKRGSNLEVELWLITAFHDKG--SLTDYLKGNIITWNELCHVAETMSRGLSYLH 129 Query: 112 KGLGFC----HSRNVLHRDLKPQNLLINRNGELKLADFGLARAF--GIPVRCYSAEVVTL 165 + + +C H ++ HRD K +N+L+ + LADFGLA F G P +V T Sbjct: 130 EDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVGTR 189 Query: 166 WYRPPDVLFGAKLYSTS----IDMWSAGCIFAELAN 197 Y P+VL GA + IDM++ G + EL + Sbjct: 190 RYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVS 225 >5WNL-A nrPDB Length = 342 Score = 50.1 bits (118), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 50/213 (23%), Positives = 104/213 (48%), Gaps = 23/213 (10%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALK---RVRLDDDDEGVPSSALREICLLKELK 59 ++ EK+G G +G V+K ++ +A+K + +DD + L E ++ K Sbjct: 21 EFAGWEKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRER---MELLEEAKKMEMAK 77 Query: 60 HKNIVRLHDVLHSDKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFLFQLLKGLGF-- 116 + I+ ++ + + + LV E+ + L+K S L ++ + + G+ F Sbjct: 78 FRYILPVYGI--CQEPVGLVMEYMETGSLEKLLAS--EPLPWDLRFRIVHETAVGMNFLH 133 Query: 117 CHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVV------TLWYRPP 170 C S +LH +LKP N+L++ + +K++DFGLA+ G+ +S ++ T+ Y PP Sbjct: 134 CMSPPLLHLNLKPANILLDAHYHVKISDFGLAKCNGM---SHSHDLSMDGLFGTIAYLPP 190 Query: 171 D-VLFGAKLYSTSIDMWSAGCIFAELANAGRPL 202 + + ++L+ T D++S + + +P Sbjct: 191 ERIREKSRLFDTKHDVYSFAIVIWGVLTQKKPF 223 >4BTK-A nrPDB Length = 337 Score = 49.3 bits (116), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 44/156 (28%), Positives = 75/156 (48%), Gaps = 12/156 (7%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALR-EICLLKELKHK 61 +++ L+KIG G +G +++A + T E VALK + P L+ E+ +LK+L+ K Sbjct: 57 RWKVLKKIGGGGFGEIYEAMDLLTRENVALKV-----ESAQQPKQVLKMEVAVLKKLQGK 111 Query: 62 N-IVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSC-NGDLDPEIVKSFLFQLLKGLGFCHS 119 + + R ++K +V + ++L S G Q+L+ + HS Sbjct: 112 DHVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHS 171 Query: 120 RNVLHRDLKPQNLLINR----NGELKLADFGLARAF 151 LHRD+KP N + R + + DFGLAR + Sbjct: 172 VGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQY 207 >4NFN-A nrPDB Length = 309 Score = 49.3 bits (116), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 44/156 (28%), Positives = 75/156 (48%), Gaps = 12/156 (7%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALR-EICLLKELKHK 61 +++ L+KIG G +G +++A + T E VALK + P L+ E+ +LK+L+ K Sbjct: 22 RWKVLKKIGGGGFGEIYEAMDLLTRENVALKV-----ESAQQPKQVLKMEVAVLKKLQGK 76 Query: 62 N-IVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSC-NGDLDPEIVKSFLFQLLKGLGFCHS 119 + + R ++K +V + ++L S G Q+L+ + HS Sbjct: 77 DHVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHS 136 Query: 120 RNVLHRDLKPQNLLINR----NGELKLADFGLARAF 151 LHRD+KP N + R + + DFGLAR + Sbjct: 137 VGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQY 172 >4LQP-A nrPDB Length = 508 Score = 49.3 bits (116), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 38/163 (23%), Positives = 73/163 (44%), Gaps = 25/163 (15%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALK---RVRLDDDDEGVPSSALREICLLKEL 58 + + ++ IG+G +G V + ++T +I A+K + + D+ A R++ L Sbjct: 102 EDFHTVKVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKDQLAHVKAERDV--LAGS 159 Query: 59 KHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDL----------DPEIVKSFLF 108 +V L+ + L L+ EF GDL ++ + ++ Sbjct: 160 DSPWVVSLYYSFQDAQYLYLIMEFL----------PGGDLMTMLIRWQLFTEDVTRFYMA 209 Query: 109 QLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAF 151 + + + H +HR +KP N+LI+ G +KL+DFGL+ F Sbjct: 210 ECILAIETIHKLGFIHRAIKPDNILIDIRGHIKLSDFGLSTGF 252 >5X18-A nrPDB Length = 295 Score = 49.3 bits (116), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 53/203 (26%), Positives = 85/203 (41%), Gaps = 20/203 (9%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALR-EICLLKELKHK- 61 Y+ +KIGEG++G +F+ N VA+K + + LR E K L Sbjct: 9 YKIGKKIGEGSFGVLFEGTNMINGVPVAIKF-----EPRKTEAPQLRDEYKTYKILNGTP 63 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN 121 NI + LV + L+ FD C + V Q++ + H+ + Sbjct: 64 NIPYAYYFGQEGLHNILVIDLLGPSLEDLFDWCGRKFSVKTVVQVAVQMITLIEDLHAHD 123 Query: 122 VLHRDLKPQNLLINRNGE-----LKLADFGLARAF-------GIPVRCYSAEVVTLWYRP 169 +++RD+KP N LI R G+ + L DFG+A+ + IP R + T Y Sbjct: 124 LIYRDIKPDNFLIGRPGQPDANNIHLIDFGMAKQYRDPKTKQHIPYREKKSLSGTARYMS 183 Query: 170 PDVLFGAKLYSTSIDMWSAGCIF 192 + G + S DM + G +F Sbjct: 184 INTHLGRE-QSRRDDMEALGHVF 205 >5AR8-A nrPDB Length = 326 Score = 48.9 bits (115), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 67/295 (22%), Positives = 127/295 (43%), Gaps = 51/295 (17%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVR-----LDDDDEGVPSSALREICLLK 56 K L + G GTV A++ + VA+K + LD + + V LRE +L Sbjct: 32 HKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDV----LREAEILH 87 Query: 57 ELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLD---------PEIVKSFL 107 + + I+ + + + + L +V E+ NG L+ P++ Sbjct: 88 KARFSYILPILGICNEPEFLGIVTEYMP----------NGSLNELLHRKTEYPDVAWPLR 137 Query: 108 FQLLK----GLGFCHSRN--VLHRDLKPQNLLINRNGELKLADFGLAR-----AFGIPVR 156 F++L G+ + H+ +LH DLK QN+L++ +K+ADFGL++ Sbjct: 138 FRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSS 197 Query: 157 CYSAEVVTLWYRPPDVLFGAKLYSTSI--DMWSAGCIFAELANAGRPLFPGNDVDDQLKR 214 + E T+ Y PP+ + SI D++S I E+ + +P DV + L+ Sbjct: 198 KSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPF---EDVTNPLQI 254 Query: 215 IFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKC 269 ++ + ++ P + + + PY + P +++++ A D + LKC Sbjct: 255 MYSV----SQGHRPVINE--ESLPYDI-PHRARMISLIESGWAQNPDERPSFLKC 302 >3Q4U-A nrPDB Length = 301 Score = 48.9 bits (115), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 53/212 (25%), Positives = 89/212 (41%), Gaps = 29/212 (13%) Query: 7 LEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRL 66 LE +G+G YG V++ + E VA+K D+ + L +L+ H+NI+ Sbjct: 13 LECVGKGRYGEVWRGSWQG--ENVAVKIFSSRDEKSWFRETELYNTVMLR---HENILGF 67 Query: 67 --HDVL--HSDKKLTLVFEFCDQDLKKYFDSCN-GDLDPEIVKSFLFQLLKGLGFCHSR- 120 D+ HS +L L+ + ++ +D LD + + GL H Sbjct: 68 IASDMTSRHSSTQLWLITHY--HEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEI 125 Query: 121 -------NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSA----EVVTLWYRP 169 + HRDLK +N+L+ +NG+ +AD GLA V T Y Sbjct: 126 FGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMA 185 Query: 170 PDVL---FGAKLYST--SIDMWSAGCIFAELA 196 P+VL + + +D+W+ G + E+A Sbjct: 186 PEVLDETIQVDCFDSYKRVDIWAFGLVLWEVA 217 >4NT4-A nrPDB Length = 312 Score = 48.9 bits (115), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 36/137 (26%), Positives = 59/137 (43%), Gaps = 13/137 (9%) Query: 77 TLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINR 136 +V E L+ F+ C + V QLL + + HSR++++RD+KP+N LI R Sbjct: 90 AMVLELLGLSLEDLFNICARKFSLKTVLMIAKQLLHRIEYVHSRHLIYRDVKPENFLIGR 149 Query: 137 NGE-----LKLADFGLARAF-------GIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSID 184 + + DFGLA+ + IP R + + T Y + G + S D Sbjct: 150 TSTKREKIIHIIDFGLAKEYIDLDTNRHIPYREHKSLTGTARYMSINTHMGRE-QSRRDD 208 Query: 185 MWSAGCIFAELANAGRP 201 + + G +F P Sbjct: 209 LEALGHMFMYFLRGSLP 225 >4O1O-A nrPDB Length = 717 Score = 47.8 bits (112), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 34/120 (28%), Positives = 51/120 (42%), Gaps = 9/120 (7%) Query: 30 VALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKK 89 VA+KR EG CL + N+V + L + C+ L++ Sbjct: 372 VAVKRF-----SEGSTRGQQEVSCLQSSRANDNVVTFYGSESDGSCLHVCLALCEYTLQE 426 Query: 90 YFDSCNGDLDP----EIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADF 145 + + GD P E ++ L L K +G H H+DL+PQN+LI+ LADF Sbjct: 427 HLANHRGDAVPNEEDESARNILSSLFKAIGELHRSGYSHQDLQPQNILIDSKNGTFLADF 486 >3UIM-A nrPDB Length = 326 Score = 47.8 bits (112), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 47/204 (23%), Positives = 88/204 (43%), Gaps = 17/204 (8%) Query: 10 IGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDV 69 +G G +G V+K + + +VA+KR++ ++ +G E+ ++ H+N++RL Sbjct: 38 LGRGGFGKVYKGRLADG-TLVAVKRLK-EERTQGGELQFQTEVEMISMAVHRNLLRLRGF 95 Query: 70 LHSDKKLTLVFEFCDQDLKKYFDSCNGD-------LDPEIVKSFLFQLLKGLGFCHSR-- 120 + + LV+ + SC + LD + +GL + H Sbjct: 96 CMTPTERLLVYPYM---ANGSVASCLRERPESQPPLDWPKRQRIALGSARGLAYLHDHCD 152 Query: 121 -NVLHRDLKPQNLLINRNGELKLADFGLARAFGIP-VRCYSAEVVTLWYRPPDVLFGAKL 178 ++HRD+K N+L++ E + DFGLA+ +A T+ + P+ L K Sbjct: 153 PKIIHRDVKAANILLDEEFEAVVGDFGLAKLMDYKDTHVTTAVRGTIGHIAPEYLSTGK- 211 Query: 179 YSTSIDMWSAGCIFAELANAGRPL 202 S D++ G + EL R Sbjct: 212 SSEKTDVFGYGVMLLELITGQRAF 235 >4Y12-A nrPDB Length = 375 Score = 46.6 bits (109), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 47/200 (23%), Positives = 88/200 (44%), Gaps = 16/200 (8%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62 +YE I G G ++ A +R + + + + D + A+ E L E+ H + Sbjct: 120 QYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAERQFLAEVVHPS 179 Query: 63 IVRL-----HDVLHSDKKLTLVFEFCD-QDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGF 116 IV++ H H D +V E+ Q LK+ S L ++L ++L L + Sbjct: 180 IVQIFNFVEHTDRHGDPVGYIVMEYVGGQSLKR---SKGQKLPVAEAIAYLLEILPALSY 236 Query: 117 CHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGA 176 HS +++ DLKP+N+++ +LKL D G + + T ++ P+++ Sbjct: 237 LHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSR----INSFGYLYGTPGFQAPEIVRTG 291 Query: 177 KLYSTSIDMWSAGCIFAELA 196 +T D+++ G A L Sbjct: 292 PTVAT--DIYTVGRTLAALT 309 >1CSN-A nrPDB Length = 298 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 40/162 (24%), Positives = 69/162 (42%), Gaps = 18/162 (11%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDD-----DEGVPSSALREICLLKEL 58 Y+ +IGEG++G +F+ N ++ VA+K D DE L + + Sbjct: 12 YKVGRRIGEGSFGVIFEGTNLLNNQQVAIKFEPRRSDAPQLRDEYRTYKLLAGCTGIPNV 71 Query: 59 KHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCH 118 + LH+VL V + L+ D C + V Q+L + H Sbjct: 72 YYFGQEGLHNVL--------VIDLLGPSLEDLLDLCGRKFSVKTVAMAAKQMLARVQSIH 123 Query: 119 SRNVLHRDLKPQNLLINRNGE-----LKLADFGLARAFGIPV 155 +++++RD+KP N LI R + + DFG+ + + PV Sbjct: 124 EKSLVYRDIKPDNFLIGRPNSKNANMIYVVDFGMVKFYRDPV 165 >2PZI-A nrPDB Length = 681 Score = 45.4 bits (106), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 47/199 (23%), Positives = 88/199 (44%), Gaps = 16/199 (8%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62 +YE I G G ++ A +R + + + + D + A+ E L E+ H + Sbjct: 81 QYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAERQFLAEVVHPS 140 Query: 63 IVRL-----HDVLHSDKKLTLVFEFCD-QDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGF 116 IV++ H H D +V E+ Q LK+ S L ++L ++L L + Sbjct: 141 IVQIFNFVEHTDRHGDPVGYIVMEYVGGQSLKR---SKGQKLPVAEAIAYLLEILPALSY 197 Query: 117 CHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGA 176 HS +++ DLKP+N+++ +LKL D G + + T ++ P+++ Sbjct: 198 LHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSR----INSFGYLYGTPGFQAPEIVRTG 252 Query: 177 KLYSTSIDMWSAGCIFAEL 195 +T D+++ G A L Sbjct: 253 PTVAT--DIYTVGRTLAAL 269 >5M07-A nrPDB Length = 276 Score = 45.4 bits (106), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 29/105 (27%), Positives = 50/105 (47%), Gaps = 6/105 (5%) Query: 50 REICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQ-DLKKYF-DSCNGDLDPEIVKSFL 107 RE + L H +I+ +HD D +L + ++ D D ++ D L V + + Sbjct: 79 RETEVAARLFHPHILEVHDRGEFDGQLWIAMDYVDGIDATQHMADRFPAVLPVGEVLAIV 138 Query: 108 FQLLKGLGFCHSRNVLHRDLKPQNLLINRNG----ELKLADFGLA 148 + L + H R +LHRD+ P N+++ + LADFG+A Sbjct: 139 TAVAGALDYAHQRGLLHRDVNPANVVLTSQSAGDQRILLADFGIA 183 >4M69-B nrPDB Length = 283 Score = 45.1 bits (105), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 48/217 (22%), Positives = 84/217 (38%), Gaps = 24/217 (11%) Query: 3 KYEKLEKIGEGTYG---TVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELK 59 K K+ I G Y K N E V + R +D EI +K+ Sbjct: 18 KTSKMSTIYRGEYHRSPVTIKVFNNPQAESVGIVRFTFND-----------EIKTMKKFD 66 Query: 60 HKNIVRLHDVLHSDK----KLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLG 115 NI+R+ + + ++V E+C+ + DL + + + +GL Sbjct: 67 SPNILRIFGICIDQTVKPPEFSIVMEYCELGTLRELLDREKDLTMSVRSLLVLRAARGLY 126 Query: 116 FCHSRNVLHRDLKPQNLLINRNGELKLADFGLAR---AFGIPVRCYSAE--VVTLWYRPP 170 H LHR++ + L+ ++KLA F L++ + + AE T++ P Sbjct: 127 RLHHSETLHRNISSSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPE 186 Query: 171 DVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGND 207 + LY +++S G + E+A P F G D Sbjct: 187 RLKNPFCLYDIKAEIYSFGIVLWEIATGKIP-FEGCD 222 >1PY5-A nrPDB Length = 326 Score = 45.1 bits (105), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 57/217 (26%), Positives = 92/217 (42%), Gaps = 41/217 (18%) Query: 8 EKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLH 67 E IG+G +G V++ K R E VA+K ++ + + + +L+ H+NI+ Sbjct: 35 ESIGKGRFGEVWRGKWR--GEEVAVKIFSSREERSWFREAEIYQTVMLR---HENILGFI 89 Query: 68 DVLHSDK----KLTLVFEFCDQDLKKYFDSCNG-DLDPEIVKSFLFQLLKGLGFCHSR-- 120 + D +L LV ++ + FD N + E + GL H Sbjct: 90 AADNKDNGTWTQLWLVSDYHEHG--SLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIV 147 Query: 121 ------NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSA----------EVVT 164 + HRDLK +N+L+ +NG +AD GLA VR SA V T Sbjct: 148 GTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLA------VRHDSATDTIDIAPNHRVGT 201 Query: 165 LWYRPPDVL---FGAKLYST--SIDMWSAGCIFAELA 196 Y P+VL K + + D+++ G +F E+A Sbjct: 202 KRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIA 238 >4IX6-A nrPDB Length = 350 Score = 44.3 bits (103), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 56/225 (24%), Positives = 82/225 (36%), Gaps = 52/225 (23%) Query: 93 SCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINR--NGELKLADFGLARA 150 +C + + K + +LL L H V+HRD+KP NL+ G LKL D G A A Sbjct: 135 ACADATELGVTKKAMRELLGSLARLHECGVVHRDVKPANLIAAEKDGGVLKLIDLGAA-A 193 Query: 151 FGIPVRCYSAEVVTLW---------YRPPDVLF-------------GAKLYST----SID 184 +P+ E + + Y D L+ AKL+ D Sbjct: 194 LCLPL----PETLNYYPGDGPADPRYAKADELYLLPPGSPRPTKDNAAKLWEAHKPDRFD 249 Query: 185 MWSAGCIFAELANAGRPLFPGNDVDDQLKRI---FRLLGTPTEEQWPSMTKLPDYKPYPM 241 WSAGC+ +LA G D L+R ++ +G ++ Sbjct: 250 SWSAGCVMLQLAVVGL------RTDAGLERFLADYKAVGYDVNA----------FRGEKS 293 Query: 242 YPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286 T + G DL Q L++ R S E AL H +F Sbjct: 294 GEYGTMDFAALDANGGAGWDLCQRLMEAERDARASCEAALSHAFF 338 >4BTF-A nrPDB Length = 469 Score = 44.3 bits (103), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 48/217 (22%), Positives = 84/217 (38%), Gaps = 24/217 (11%) Query: 3 KYEKLEKIGEGTYG---TVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELK 59 K K+ I G Y K N E V + R +D EI +K+ Sbjct: 204 KTSKMSTIYRGEYHRSPVTIKVFNNPQAESVGIVRFTFND-----------EIKTMKKFD 252 Query: 60 HKNIVRLHDVLHSDK----KLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLG 115 NI+R+ + + ++V E+C+ + DL + + + +GL Sbjct: 253 SPNILRIFGICIDQTVKPPEFSIVMEYCELGTLRELLDREKDLTMSVRSLLVLRAARGLY 312 Query: 116 FCHSRNVLHRDLKPQNLLINRNGELKLADFGLAR---AFGIPVRCYSAE--VVTLWYRPP 170 H LHR++ + L+ ++KLA F L++ + + AE T++ P Sbjct: 313 RLHHSETLHRNISSSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPE 372 Query: 171 DVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGND 207 + LY +++S G + E+A P F G D Sbjct: 373 RLKNPFCLYDIKAEIYSFGIVLWEIATGKIP-FEGCD 408 >4TN6-A nrPDB Length = 318 Score = 43.9 bits (102), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 24/78 (30%), Positives = 41/78 (52%), Gaps = 3/78 (3%) Query: 77 TLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLL--I 134 +V E L+ F+ C+ + V Q++ + + HS+N +HRD+KP N L + Sbjct: 79 VMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGL 138 Query: 135 NRNGEL-KLADFGLARAF 151 + G L + DFGLA+ + Sbjct: 139 GKKGNLVYIIDFGLAKKY 156 >4L00-A nrPDB Length = 304 Score = 43.9 bits (102), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 49/207 (23%), Positives = 90/207 (43%), Gaps = 18/207 (8%) Query: 8 EKIGEGT-----YGTVFKAKNRE-THEIVALKRV--RLDDDDEGVPSSALREICLLKELK 59 E +G GT GT+ K+ E T E +K + LD + + +++++ Sbjct: 31 EHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVS 90 Query: 60 HKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLF----QLLKGLG 115 HK+IV L+ V D + +V EF + F D+ + + F QL L Sbjct: 91 HKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDV---LTTPWKFKVAKQLASALS 147 Query: 116 FCHSRNVLHRDLKPQNLLINRNG-ELKLADFGLARAFGIPVRCYSAE--VVTLWYRPPDV 172 + ++++H ++ +NLL+ R G + + F GIP+ S + + + + P+ Sbjct: 148 YLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPEC 207 Query: 173 LFGAKLYSTSIDMWSAGCIFAELANAG 199 + +K S + D WS G E+ G Sbjct: 208 VEDSKNLSVAADKWSFGTTLWEICYNG 234 >5X1R-A nrPDB Length = 302 Score = 43.5 bits (101), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 38/167 (22%), Positives = 66/167 (39%), Gaps = 20/167 (11%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRV-------RLDDDDEGVP---------- 45 ++E E IGEG +G V++A + + +A+K R DD G+ Sbjct: 22 EFEIQEAIGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAKRNDDLSIGLRGERFGKTFQA 81 Query: 46 --SSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGD-LDPEI 102 +S ++E LL H ++ + + + +F K + + +D Sbjct: 82 GLNSFIQEARLLARFSHPGLLHVLRFWEENGTAYMGTQFYSGTTLKNLQAQQPEKIDEAW 141 Query: 103 VKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLAR 149 ++ L L + H LHRD+ N+ I + L DFG AR Sbjct: 142 IRRLLPPLFSAINTIHQEGYLHRDISLDNIQIQESQLPVLLDFGSAR 188 >4XHH-A nrPDB Length = 403 Score = 43.5 bits (101), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 34/153 (22%), Positives = 64/153 (41%), Gaps = 6/153 (3%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 +K+ KIG G++G ++ N + E VA +RL+ P Sbjct: 7 RKFRIGRKIGSGSFGDIYHGTNLISGEEVA---IRLESIRSRHPQLDYESRVYKYLSGGV 63 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN 121 I + + +V + L+ F+ C+ + V Q++ + + H R+ Sbjct: 64 GIPFIRWFGREGEYNAMVIDLLGPSLEDLFNYCHRKFSFKTVIMLALQMICRVQYIHGRS 123 Query: 122 VLHRDLKPQNLLIN---RNGELKLADFGLARAF 151 +HRD+KP N L+ R + + DFGL++ + Sbjct: 124 FIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKY 156 >4XHL-A nrPDB Length = 394 Score = 43.1 bits (100), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 45/210 (21%), Positives = 79/210 (37%), Gaps = 14/210 (6%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 +K+ KIG G++G ++ N + E VA +RL+ P Sbjct: 7 RKFRIGRKIGSGSFGDIYHGTNLISGEEVA---IRLESIRSRHPQLDYESRVYRYLSGGV 63 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN 121 I + + +V + L+ F+ C+ + V Q+ + + H R+ Sbjct: 64 GIPFIRWFGREGEYNAMVIDLLGPSLEDLFNYCHRRFSFKTVIMLALQMFCRIQYIHGRS 123 Query: 122 VLHRDLKPQNLLIN---RNGELKLADFGLARAF-------GIPVRCYSAEVVTLWYRPPD 171 +HRD+KP N L+ R + + DFGL++ + IP R + T Y + Sbjct: 124 FIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTARYASVN 183 Query: 172 VLFGAKLYSTSIDMWSAGCIFAELANAGRP 201 G + S D+ S G + P Sbjct: 184 THLGIE-QSRRDDLESLGYVLIYFCKGSLP 212 >5L2Q-C nrPDB Length = 320 Score = 41.2 bits (95), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 23/99 (23%), Positives = 44/99 (44%), Gaps = 1/99 (1%) Query: 106 FLFQLLKGLGFCHSRNVLHRDLKPQNLLIN-RNGELKLADFGLARAFGIPVRCYSAEVVT 164 + +++ + H +N++HRDLK N+++N R + + +F L + + + Sbjct: 158 IFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEGDLLKDQRGS 217 Query: 165 LWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLF 203 Y PDVL G DMW+ G + + P + Sbjct: 218 PAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPFY 256 >5E8V-A nrPDB Length = 316 Score = 40.8 bits (94), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 49/208 (23%), Positives = 86/208 (41%), Gaps = 33/208 (15%) Query: 10 IGEGTYGTVFKAK-NRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHD 68 +G+G + V+KAK + T E V++ +E ++I LKH+NI++ Sbjct: 17 VGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQFLT 76 Query: 69 VLHSDKKLT----LVFEF-CDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN-- 121 +L L+ F +L++Y + E ++ L +G+ HS + Sbjct: 77 AEERKTELGKQYWLITAFHAKGNLQEYL--TRHVISWEDLRKLGSSLARGIAHLHSDHTP 134 Query: 122 -------VLHRDLKPQNLLINRNGELKLADFGLAR----AFGIPVRCYSAEVVTLWYRPP 170 ++HRDLK N+L+ + L DFGL+ + S +V T Y P Sbjct: 135 CGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAP 194 Query: 171 DVLFGA------------KLYSTSIDMW 186 +VL A +YS ++ +W Sbjct: 195 EVLASAMNLENVESFKQTDVYSMALVLW 222 >4OAU-C nrPDB Length = 699 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 29/109 (26%), Positives = 48/109 (44%), Gaps = 5/109 (4%) Query: 42 EGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGD---- 97 EG P + CL ++ ++V + L + C+Q L+ D G+ Sbjct: 376 EGSPRAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVEN 435 Query: 98 LDPEIVKSFLFQLLKGLGFCH-SRNVLHRDLKPQNLLINRNGELKLADF 145 + E ++ L + K + H S H+DL+PQN+LI+ LADF Sbjct: 436 EEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADF 484 >5UU1-A nrPDB Length = 324 Score = 38.9 bits (89), Expect = 0.002, Method: Compositional matrix adjust. Identities = 41/162 (25%), Positives = 68/162 (41%), Gaps = 19/162 (11%) Query: 8 EKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALR-------EICLLKELKH 60 +KIG G +G ++ A E A V+++ + G S L+ + C+ K ++ Sbjct: 22 KKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDCIKKWIER 81 Query: 61 KNIVRLHDVLHSDKKLT---------LVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLL 111 K + L L LT +V E DL+K NG V ++L Sbjct: 82 KQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQK-ISGQNGTFKKSTVLQLGIRML 140 Query: 112 KGLGFCHSRNVLHRDLKPQNLLINRNG--ELKLADFGLARAF 151 L + H +H D+K NLL+ ++ LAD+GL+ + Sbjct: 141 DVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRY 182 >4L68-A nrPDB Length = 340 Score = 37.7 bits (86), Expect = 0.005, Method: Compositional matrix adjust. Identities = 44/178 (24%), Positives = 77/178 (43%), Gaps = 27/178 (15%) Query: 51 EICLLKELKHKNIVRLHDVLHSDKKLTLVFEF-CDQDLKKYFDSCNGDLDPEIVKSFLFQ 109 E+ L EL+H N+ L +++ LV+++ + L DS G+LD Sbjct: 85 EMNQLWELRHSNLAPLLGFCVVEEEKFLVYKYMSNGTLHSLLDSNRGELDWSTRFRIGLG 144 Query: 110 LLKGLGFCHSRN---VLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVT-- 164 +GL + H +LH+++ +LI+ + + ++ D GLAR +P + +T Sbjct: 145 AARGLAWLHHGCRPPILHQNICSSVILIDEDFDARIIDSGLARLM-VPSDNNESSFMTGD 203 Query: 165 ---LWYRPPDVLFGAKLYSTSI------DMWSAGCIFAELANA----GRPLFPGNDVD 209 Y P+ YST++ D++ G + ELA G F G+ VD Sbjct: 204 LGEFGYVAPE-------YSTTMLASLKGDVYGLGVVLLELATGLKAVGGEGFKGSLVD 254 >2RSV-A nrPDB Length = 403 Score = 36.2 bits (82), Expect = 0.019, Method: Compositional matrix adjust. Identities = 27/109 (24%), Positives = 48/109 (44%), Gaps = 13/109 (11%) Query: 66 LHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHR 125 LHD + ++ F DL+K +++ + V ++L L + H +H Sbjct: 125 LHDKNGKSYRFMIMDRF-GSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHG 183 Query: 126 DLKPQNLLINRNG--ELKLADFGLARAF---GI-------PVRCYSAEV 162 D+K NLL+N ++ L D+GLA + G+ P RC+ + Sbjct: 184 DIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTI 232 >2LAV-A nrPDB Length = 361 Score = 35.8 bits (81), Expect = 0.022, Method: Compositional matrix adjust. Identities = 27/109 (24%), Positives = 48/109 (44%), Gaps = 13/109 (11%) Query: 66 LHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHR 125 LHD + ++ F DL+K +++ + V ++L L + H +H Sbjct: 118 LHDKNGKSYRFMIMDRF-GSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHG 176 Query: 126 DLKPQNLLINRNG--ELKLADFGLARAF---GI-------PVRCYSAEV 162 D+K NLL+N ++ L D+GLA + G+ P RC+ + Sbjct: 177 DIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTI 225 >3MY0-A nrPDB Length = 305 Score = 34.7 bits (78), Expect = 0.046, Method: Compositional matrix adjust. Identities = 37/155 (23%), Positives = 62/155 (40%), Gaps = 20/155 (12%) Query: 7 LEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRL 66 +E +G+G YG V++ E VA+K D+ + + LL+ H NI+ Sbjct: 13 VECVGKGRYGEVWRGLWHG--ESVAVKIFSSRDEQSWFRETEIYNTVLLR---HDNILGF 67 Query: 67 ----HDVLHSDKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR- 120 +S +L L+ + + L + L+P + GL H Sbjct: 68 IASDMTSRNSSTQLWLITHYHEHGSLYDFLQ--RQTLEPHLALRLAVSAACGLAHLHVEI 125 Query: 121 -------NVLHRDLKPQNLLINRNGELKLADFGLA 148 + HRD K +N+L+ N + +AD GLA Sbjct: 126 FGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLA 160 >6G4J-A nrPDB Length = 315 Score = 34.3 bits (77), Expect = 0.057, Method: Compositional matrix adjust. Identities = 39/167 (23%), Positives = 69/167 (41%), Gaps = 23/167 (13%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 Y +++G+G G V+ A+ + H VALK + DD + S E+ +LK Sbjct: 28 YTLRKQLGKGANGIVYLAETSDGH--VALK---VSDDSLSITS----EVNVLKSFSKAQS 78 Query: 64 VRLHD---------VLHSDKKLTL-VFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKG 113 V + + ++ K++ E+ L + S G E + + QLL Sbjct: 79 VTMGPSFFDTDDAYIPSANTKVSFYAMEYIKGPLLLKYVSDKG---AEWIPVLMIQLLSS 135 Query: 114 LGFCHSRNVLHRDLKPQNLLINR-NGELKLADFGLARAFGIPVRCYS 159 L H + + DLKP NL++ ++ D G G ++ Y+ Sbjct: 136 LSVLHQQGWIFGDLKPDNLIVTGPPARIRCIDVGGTTKEGRAIKEYT 182 >5CLR-A nrPDB Length = 451 Score = 33.1 bits (74), Expect = 0.15, Method: Compositional matrix adjust. Identities = 12/29 (41%), Positives = 20/29 (68%) Query: 118 HSRNVLHRDLKPQNLLINRNGELKLADFG 146 H ++HRDLKP N++++ + + L DFG Sbjct: 193 HELGLIHRDLKPGNIMLDADMQCHLVDFG 221 >5OAT-A nrPDB Length = 411 Score = 32.0 bits (71), Expect = 0.33, Method: Compositional matrix adjust. Identities = 45/185 (24%), Positives = 70/185 (37%), Gaps = 47/185 (25%) Query: 112 KGLGFCHSRNVLHRDLKPQNLLINRNGE----LKLADFGLARA-----FGIPVRCYSAEV 162 +G+ + + HRDLK NLL++ + L ++DFG A +P Y + Sbjct: 164 EGVAHMTAHGIAHRDLKSDNLLLDTSEPESPILVISDFGCCLADKTNGLSLPYTSYEMDK 223 Query: 163 -VTLWYRPPDVL------FGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRI 215 P+++ F YS + D+W+ G I E+ N P + +LK Sbjct: 224 GGNTALMAPEIICQKPGTFSVLNYSKA-DLWAVGAIAYEIFNCHNPFYG----PSRLKNF 278 Query: 216 FRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRI 275 G + KLPD P + L+ NLLK NP +R+ Sbjct: 279 NYKEG--------DLPKLPDEVP------------------TVIQALVANLLKRNPNKRL 312 Query: 276 SAEEA 280 E A Sbjct: 313 DPEVA 317 >3G1Z-A nrPDB Length = 326 Score = 30.4 bits (67), Expect = 1.0, Method: Compositional matrix adjust. Identities = 21/56 (37%), Positives = 28/56 (50%), Gaps = 12/56 (21%) Query: 228 PSMTKLPDYKP-YPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQ 282 P T L Y+P Y MY L+N V DLLQ +L C P + +S ++A Q Sbjct: 111 PEFTMLEWYRPHYDMY----RLMNEVD-------DLLQQVLDCQPAESLSYQQAFQ 155 >6G38-A nrPDB Length = 357 Score = 30.0 bits (66), Expect = 1.3, Method: Compositional matrix adjust. Identities = 21/63 (33%), Positives = 32/63 (50%), Gaps = 8/63 (12%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDD------EGVPSSALREICLL 55 +K ++ EKIGEG +G VF+ H VA+K + ++ D + L EI + Sbjct: 41 EKLQRCEKIGEGVFGEVFQTI--ADHTPVAIKIIAIEGPDLVNGSHQKTFEEILPEIIIS 98 Query: 56 KEL 58 KEL Sbjct: 99 KEL 101 >4AZW-A nrPDB Length = 471 Score = 29.6 bits (65), Expect = 1.6, Method: Compositional matrix adjust. Identities = 12/43 (27%), Positives = 22/43 (51%) Query: 104 KSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFG 146 + L LL+ L + H D++P N++++ +L DFG Sbjct: 342 EKILGSLLRSLAALEKKGFWHDDVRPWNVMVDARQHARLIDFG 384 >4WWA-A nrPDB Length = 261 Score = 29.6 bits (65), Expect = 1.7, Method: Compositional matrix adjust. Identities = 18/66 (27%), Positives = 33/66 (50%), Gaps = 3/66 (4%) Query: 86 DLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGEL---KL 142 +LK + + D ++V + L ++ + +G H + H DL N+++ R+G L Sbjct: 121 NLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHL 180 Query: 143 ADFGLA 148 DFGL Sbjct: 181 IDFGLG 186 >4AZV-A nrPDB Length = 569 Score = 29.6 bits (65), Expect = 1.7, Method: Compositional matrix adjust. Identities = 12/43 (27%), Positives = 22/43 (51%) Query: 104 KSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFG 146 + L LL+ L + H D++P N++++ +L DFG Sbjct: 342 EKILGSLLRSLAALEKQGFWHDDVRPWNVMVDARQHARLIDFG 384 >6CNC-N nrPDB Length = 422 Score = 29.3 bits (64), Expect = 2.0, Method: Compositional matrix adjust. Identities = 13/37 (35%), Positives = 23/37 (62%) Query: 38 DDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDK 74 DDD+EGV S + ++ + KE + +N++ D S+K Sbjct: 144 DDDNEGVASKSKKKFNMGKEFEARNLIEDEDDGESEK 180 >4CYJ-A nrPDB Length = 438 Score = 29.3 bits (64), Expect = 2.2, Method: Compositional matrix adjust. Identities = 30/143 (20%), Positives = 66/143 (46%), Gaps = 22/143 (15%) Query: 18 VFKAKNRETHEIVALKRV---RLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHS-- 72 V+KA+N AL+R+ RL ++ + L + K++K+ +IV +H+V + Sbjct: 71 VYKAQNSRNGRHYALRRLEGYRLTNE-----KAILNVMKDWKKIKNASIVTIHEVFTTRE 125 Query: 73 --DKKLTLVFEF--CDQDLKKY-FDSCNGD-------LDPEIVKSFLFQLLKGLGFCHSR 120 D L ++F + L+++ F +G+ + + ++ Q+ L HS Sbjct: 126 FGDSSLIFAYDFHPLSKTLQEHHFQPIHGNRYRPPPAVPENTIWGYICQIANALKTIHSN 185 Query: 121 NVLHRDLKPQNLLINRNGELKLA 143 + R L+P +++ ++L+ Sbjct: 186 RLAARCLEPSKIILTDINRIRLS 208 >6J6I-B nrPDB Length = 351 Score = 29.3 bits (64), Expect = 2.4, Method: Compositional matrix adjust. Identities = 9/27 (33%), Positives = 19/27 (70%) Query: 122 VLHRDLKPQNLLINRNGELKLADFGLA 148 ++HRD+KP ++ +++N KL+D + Sbjct: 187 IIHRDVKPMHVFLDKNWTAKLSDLSFS 213 >4CI6-B nrPDB Length = 643 Score = 28.9 bits (63), Expect = 2.8, Method: Compositional matrix adjust. Identities = 21/76 (27%), Positives = 34/76 (44%), Gaps = 6/76 (7%) Query: 83 CDQDLKKYFDSC-NGDLDPE----IVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINR- 136 C L+ DS G ++ E +K +LL ++H D+KP N++ +R Sbjct: 133 CSDTLRSLADSWKQGKINSEAYWGTIKFIAHRLLDVTNHLAKAGIVHNDIKPGNVVFDRA 192 Query: 137 NGELKLADFGLARAFG 152 +GE + D GL G Sbjct: 193 SGEPVVIDLGLHSRSG 208 >5KH2-A nrPDB Length = 272 Score = 27.7 bits (60), Expect = 6.6, Method: Compositional matrix adjust. Identities = 15/50 (30%), Positives = 28/50 (56%), Gaps = 11/50 (22%) Query: 96 GDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADF 145 GD+ E++ ++LF L +DL+ +L+I +GEL+L++F Sbjct: 192 GDITEELIGNYLFT-----------QHLPKDLRDPDLIIRTSGELRLSNF 230 >6EQI-C nrPDB Length = 433 Score = 27.3 bits (59), Expect = 8.5, Method: Compositional matrix adjust. Identities = 31/151 (20%), Positives = 54/151 (35%), Gaps = 41/151 (27%) Query: 112 KGLGFCHSRNVLHRDLKPQNLLINRNG-----ELKLADFGLARAFGIPVRCYSAEVVTLW 166 + + + N+ HRDLK N+L++ + + + DFG C + + Sbjct: 178 EAVAHMNIHNISHRDLKSDNILVDLSEGDAYPTIVITDFGCC-------LCDKQNGLVIP 230 Query: 167 YRPPDVLFGAK------------------LYSTSIDMWSAGCIFAELANAGRPLFPGNDV 208 YR D G L D+W+ G I E+ N P + Sbjct: 231 YRSEDQDKGGNRALMAPEIANAKPGTFSWLNYKKSDLWAVGAIAYEIFNIDNPFY----- 285 Query: 209 DDQLKRIFRLLGTPTEEQWPSMTKLPDYKPY 239 + +LL +E+ + +LPD P+ Sbjct: 286 ----DKTMKLLSKSYKEE--DLPELPDTIPF 310 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 4AU8-A nrPDB 410 e-115 2BPM-A nrPDB 357 3e-99 3NIZ-A nrPDB 346 1e-95 1V0B-A nrPDB 342 7e-95 6GU6-A nrPDB 338 2e-93 4KRC-A nrPDB 329 1e-90 1UA2-A nrPDB 315 2e-86 5G6V-A nrPDB 311 3e-85 4AGU-A nrPDB 301 3e-82 3GC0-A nrPDB 298 2e-81 4BBM-A nrPDB 297 3e-81 5EFQ-A nrPDB 297 5e-81 4NST-A nrPDB 297 5e-81 5Z33-A nrPDB 291 2e-79 4EWQ-A nrPDB 291 2e-79 1G3N-A nrPDB 291 2e-79 2F9G-A nrPDB 285 1e-77 3OHT-A nrPDB 285 2e-77 3MIA-A nrPDB 284 2e-77 4QTB-A nrPDB 284 3e-77 5NGU-A nrPDB 283 5e-77 1CM8-A nrPDB 281 2e-76 3GC9-A nrPDB 280 6e-76 4IC8-A nrPDB 280 6e-76 4BGQ-A nrPDB 280 7e-76 6DTL-A nrPDB 279 9e-76 3OZ6-A nrPDB 279 9e-76 2W96-B nrPDB 279 1e-75 4QNY-A nrPDB 279 1e-75 3ZDU-A nrPDB 278 2e-75 4MYG-A nrPDB 277 3e-75 4ZSG-A nrPDB 275 1e-74 3NCG-A nrPDB 273 5e-74 5JN2-A nrPDB 273 8e-74 3LIJ-A nrPDB 272 1e-73 1JNK-A nrPDB 272 1e-73 2XS0-A nrPDB 271 2e-73 5AWM-A nrPDB 271 3e-73 4MVF-A nrPDB 270 4e-73 3DFA-A nrPDB 270 4e-73 3HZT-A nrPDB 269 1e-72 3E7O-A nrPDB 269 1e-72 3DXN-A nrPDB 266 7e-72 3MA6-A nrPDB 266 7e-72 3FI2-A nrPDB 265 1e-71 5AIR-A nrPDB 263 7e-71 3RP9-A nrPDB 260 5e-70 3N9X-A nrPDB 259 8e-70 2VN9-A nrPDB 259 8e-70 4O2Z-A nrPDB 259 1e-69 5FG8-A nrPDB 257 3e-69 5ES1-A nrPDB 257 5e-69 4YZB-A nrPDB 256 8e-69 3NIE-A nrPDB 255 1e-68 2QNJ-A nrPDB 255 1e-68 5U6Y-A nrPDB 255 2e-68 3COM-A nrPDB 255 2e-68 5IG1-A nrPDB 254 3e-68 4REW-A nrPDB 254 4e-68 2V7O-A nrPDB 253 5e-68 2BDW-A nrPDB 253 5e-68 4E7W-A nrPDB 253 6e-68 5YKS-A nrPDB 253 6e-68 5KZ7-A nrPDB 253 6e-68 2VZ6-A nrPDB 253 9e-68 3Q5I-A nrPDB 252 9e-68 4RGJ-A nrPDB 252 1e-67 3MN3-A nrPDB 252 1e-67 3H4J-B nrPDB 252 2e-67 4LG4-A nrPDB 252 2e-67 3BHH-A nrPDB 251 2e-67 5WAX-A nrPDB 251 3e-67 4UZD-A nrPDB 251 3e-67 3PG1-A nrPDB 251 3e-67 4FG9-A nrPDB 250 5e-67 3KK8-A nrPDB 250 5e-67 4CZT-A nrPDB 250 5e-67 3D2K-A nrPDB 250 6e-67 6AO5-A nrPDB 250 7e-67 5XZW-A nrPDB 250 7e-67 3SOA-A nrPDB 249 1e-66 2JC6-A nrPDB 248 2e-66 4CFF-A nrPDB 248 2e-66 4CFH-A nrPDB 248 2e-66 5KCV-A nrPDB 248 2e-66 2I6L-A nrPDB 248 2e-66 5EZV-A nrPDB 248 2e-66 4RED-A nrPDB 248 3e-66 4D28-A nrPDB 247 5e-66 3MV5-A nrPDB 246 1e-65 2JDO-A nrPDB 245 1e-65 5J5T-A nrPDB 245 2e-65 6FD3-A nrPDB 244 4e-65 4FIE-A nrPDB 243 5e-65 5Y86-A nrPDB 243 7e-65 3TAC-A nrPDB 243 9e-65 3ZUT-A nrPDB 242 1e-64 2YCR-A nrPDB 242 1e-64 4JDH-A nrPDB 241 3e-64 2UV2-A nrPDB 241 3e-64 4L42-A nrPDB 241 3e-64 2YZA-A nrPDB 241 3e-64 4XBR-A nrPDB 241 3e-64 2W4O-A nrPDB 241 3e-64 2Q0N-A nrPDB 241 3e-64 4JXF-A nrPDB 241 3e-64 2Y7J-A nrPDB 241 3e-64 3UDB-A nrPDB 240 4e-64 3E3P-A nrPDB 240 5e-64 4CQG-A nrPDB 240 7e-64 2F57-A nrPDB 239 8e-64 4NIF-A nrPDB 239 9e-64 5D9K-A nrPDB 239 1e-63 4KS7-A nrPDB 239 1e-63 4D2V-A nrPDB 239 1e-63 4RLP-A nrPDB 238 1e-63 4PDS-A nrPDB 238 2e-63 3I6U-A nrPDB 238 2e-63 6C9D-A nrPDB 238 2e-63 1PHK-A nrPDB 238 2e-63 2JAM-A nrPDB 238 3e-63 2HAK-A nrPDB 238 3e-63 2J90-A nrPDB 237 3e-63 4B6L-A nrPDB 237 4e-63 5ZTN-A nrPDB 237 4e-63 3EB0-A nrPDB 237 5e-63 3DB8-A nrPDB 237 6e-63 3UC3-A nrPDB 236 7e-63 2YAB-A nrPDB 236 8e-63 1FOT-A nrPDB 235 1e-62 4JG6-A nrPDB 235 1e-62 5F9E-A nrPDB 235 2e-62 3Q53-A nrPDB 235 2e-62 4I6B-A nrPDB 234 3e-62 6FDY-U nrPDB 233 4e-62 2XIK-A nrPDB 233 5e-62 3F3Z-A nrPDB 233 5e-62 3HDN-A nrPDB 233 6e-62 2Z7Q-A nrPDB 233 6e-62 1VZO-A nrPDB 233 7e-62 6ED6-A nrPDB 233 9e-62 3GUB-A nrPDB 233 9e-62 6HXF-B nrPDB 233 9e-62 4QMW-A nrPDB 233 1e-61 3TKU-A nrPDB 232 1e-61 4AW2-A nrPDB 232 1e-61 6E9W-A nrPDB 232 1e-61 2A27-A nrPDB 232 2e-61 3TXO-A nrPDB 232 2e-61 3DAK-A nrPDB 232 2e-61 3UTO-A nrPDB 232 2e-61 1ZWS-A nrPDB 231 3e-61 4APC-A nrPDB 230 5e-61 5D7A-A nrPDB 230 7e-61 1KOA-A nrPDB 230 7e-61 4YNZ-A nrPDB 230 8e-61 5JZN-A nrPDB 229 1e-60 6CMJ-A nrPDB 229 1e-60 4FZF-B nrPDB 229 1e-60 5LOH-A nrPDB 228 1e-60 3A8W-A nrPDB 228 2e-60 4CSV-A nrPDB 228 2e-60 2OU7-A nrPDB 228 2e-60 5DBX-A nrPDB 227 4e-60 3IS5-A nrPDB 227 5e-60 4J52-A nrPDB 227 6e-60 5N23-A nrPDB 227 6e-60 4B8L-A nrPDB 226 1e-59 5X3F-B nrPDB 225 1e-59 4RA4-A nrPDB 225 1e-59 6O6Q-A nrPDB 225 2e-59 6CQF-A nrPDB 224 3e-59 4WB7-A nrPDB 224 3e-59 2X4F-A nrPDB 224 4e-59 1U5R-A nrPDB 223 5e-59 5YV8-A nrPDB 223 5e-59 2HW6-A nrPDB 223 8e-59 3ORZ-A nrPDB 223 9e-59 2VD5-A nrPDB 222 1e-58 2GCD-A nrPDB 222 1e-58 1KOB-A nrPDB 222 1e-58 3PFQ-A nrPDB 220 4e-58 5DYK-A nrPDB 220 5e-58 5KKR-C nrPDB 220 7e-58 3HKO-A nrPDB 219 1e-57 5X8I-B nrPDB 218 2e-57 4CRL-A nrPDB 218 3e-57 2I0E-A nrPDB 217 4e-57 6BDL-A nrPDB 217 4e-57 4AF3-A nrPDB 217 4e-57 3ALO-A nrPDB 217 4e-57 3NYO-A nrPDB 217 4e-57 3EQC-A nrPDB 217 4e-57 3KN6-A nrPDB 217 7e-57 2BRG-A nrPDB 216 8e-57 5FET-A nrPDB 216 9e-57 3VN9-A nrPDB 216 9e-57 6E2O-A nrPDB 215 2e-56 2WQN-A nrPDB 215 2e-56 2PVN-A nrPDB 215 2e-56 4U41-A nrPDB 215 3e-56 4C0T-A nrPDB 214 3e-56 6HMD-A nrPDB 213 6e-56 4MD7-E nrPDB 213 6e-56 4FR4-A nrPDB 213 9e-56 6FYV-A nrPDB 213 1e-55 3FME-A nrPDB 213 1e-55 6CKI-A nrPDB 212 1e-55 3LM0-A nrPDB 212 1e-55 4AN9-A nrPDB 212 2e-55 4TNB-A nrPDB 212 2e-55 2FO0-A nrPDB 211 3e-55 5UUU-A nrPDB 211 4e-55 3C51-A nrPDB 211 4e-55 4XEY-B nrPDB 210 4e-55 5XVU-A nrPDB 210 5e-55 3PVW-A nrPDB 210 6e-55 3PPZ-A nrPDB 209 1e-54 4WNO-A nrPDB 209 1e-54 6CCF-A nrPDB 208 2e-54 6EII-A nrPDB 208 2e-54 6NPU-A nrPDB 208 3e-54 6QAU-A nrPDB 207 4e-54 2XYN-A nrPDB 207 4e-54 2WO6-A nrPDB 207 6e-54 6BXI-A nrPDB 206 8e-54 1TKI-A nrPDB 205 1e-53 5O2C-A nrPDB 205 2e-53 5O2B-A nrPDB 205 3e-53 4E93-A nrPDB 205 3e-53 5H2U-A nrPDB 205 3e-53 3FXW-A nrPDB 204 5e-53 2H8H-A nrPDB 203 5e-53 5UNP-A nrPDB 203 6e-53 6GVJ-A nrPDB 203 7e-53 4P5Q-A nrPDB 202 1e-52 1S9I-A nrPDB 201 2e-52 2XNP-A nrPDB 201 2e-52 5B2L-A nrPDB 201 3e-52 5MJB-A nrPDB 201 3e-52 5L6P-A nrPDB 201 4e-52 4PWN-A nrPDB 201 4e-52 4AT3-A nrPDB 201 4e-52 1NY3-A nrPDB 200 5e-52 2WTK-C nrPDB 200 5e-52 6F3F-A nrPDB 200 5e-52 3DKO-A nrPDB 200 6e-52 2DQ7-X nrPDB 200 8e-52 3RAW-A nrPDB 200 8e-52 3QGY-A nrPDB 200 8e-52 4XI2-A nrPDB 200 9e-52 2OZA-A nrPDB 199 1e-51 2R2P-A nrPDB 199 1e-51 3KA0-A nrPDB 199 1e-51 2Y6O-A nrPDB 199 1e-51 3HMP-A nrPDB 198 2e-51 4EBW-A nrPDB 198 2e-51 4EQM-A nrPDB 198 2e-51 4Y93-A nrPDB 198 2e-51 6E4F-A nrPDB 198 2e-51 3TT0-A nrPDB 198 2e-51 4UYA-A nrPDB 198 2e-51 4OLI-A nrPDB 198 3e-51 3SXS-A nrPDB 198 3e-51 5A46-A nrPDB 197 4e-51 1JPA-A nrPDB 197 4e-51 3PP0-A nrPDB 197 4e-51 4YHJ-A nrPDB 197 5e-51 4UY9-A nrPDB 197 5e-51 2ZMD-A nrPDB 196 8e-51 3GQL-A nrPDB 196 1e-50 5GNK-A nrPDB 196 1e-50 2VWV-A nrPDB 196 1e-50 5AP3-A nrPDB 196 1e-50 2J0K-A nrPDB 196 1e-50 3ORP-A nrPDB 196 1e-50 6GQK-A nrPDB 195 1e-50 3V5Q-A nrPDB 195 1e-50 3DTC-A nrPDB 195 1e-50 5SYS-A nrPDB 195 2e-50 3LZB-A nrPDB 195 2e-50 3OMV-A nrPDB 195 2e-50 3BBT-B nrPDB 195 2e-50 6DBM-A nrPDB 195 2e-50 2PSQ-A nrPDB 195 2e-50 4K33-A nrPDB 195 3e-50 4PDO-A nrPDB 194 3e-50 1BYG-A nrPDB 194 4e-50 4OTD-A nrPDB 194 4e-50 1K9A-A nrPDB 194 5e-50 5HI2-A nrPDB 193 5e-50 4IAN-A nrPDB 193 5e-50 3A4O-X nrPDB 193 8e-50 4XCU-A nrPDB 193 1e-49 1ZXE-A nrPDB 193 1e-49 4GS6-A nrPDB 192 1e-49 3CJF-A nrPDB 192 1e-49 5KMM-A nrPDB 192 2e-49 5X02-A nrPDB 192 2e-49 5VO2-A nrPDB 191 3e-49 4E20-A nrPDB 191 3e-49 4XUF-A nrPDB 191 4e-49 4LRM-A nrPDB 190 4e-49 4XLV-A nrPDB 190 5e-49 5EG3-A nrPDB 190 5e-49 5TUR-A nrPDB 190 5e-49 5O0Y-A nrPDB 190 6e-49 2OGV-A nrPDB 190 6e-49 2PL0-A nrPDB 190 7e-49 6FEX-A nrPDB 190 9e-49 4HZS-A nrPDB 189 9e-49 2W1I-A nrPDB 189 9e-49 6BSD-A nrPDB 189 1e-48 4LFI-A nrPDB 189 1e-48 3KUL-B nrPDB 189 1e-48 5AMN-A nrPDB 189 1e-48 2HK5-A nrPDB 189 1e-48 6DBN-A nrPDB 189 1e-48 3IO7-A nrPDB 189 1e-48 3BEA-A nrPDB 188 2e-48 4KIK-B nrPDB 188 2e-48 3BGP-A nrPDB 188 2e-48 5HIE-A nrPDB 188 3e-48 1U54-B nrPDB 188 3e-48 3DLS-A nrPDB 187 4e-48 4CRS-A nrPDB 187 4e-48 3KRL-A nrPDB 187 5e-48 4RC3-A nrPDB 187 5e-48 1U59-A nrPDB 187 5e-48 1AD5-A nrPDB 186 6e-48 4M7I-A nrPDB 186 8e-48 2OZO-A nrPDB 186 8e-48 4H1J-A nrPDB 186 9e-48 5HLW-A nrPDB 186 1e-47 3C1X-A nrPDB 186 1e-47 2X7G-A nrPDB 185 2e-47 1FVR-A nrPDB 185 2e-47 1LUF-A nrPDB 185 2e-47 5X5O-A nrPDB 185 2e-47 4WUA-A nrPDB 185 3e-47 4R7H-A nrPDB 185 3e-47 5FM2-A nrPDB 185 3e-47 5VD3-A nrPDB 184 4e-47 2JD5-A nrPDB 184 4e-47 3I81-A nrPDB 183 6e-47 4HVI-A nrPDB 183 7e-47 4YFF-A nrPDB 183 8e-47 3QA8-A nrPDB 182 2e-46 4OW8-A nrPDB 181 2e-46 6CTH-A nrPDB 181 2e-46 6B2Q-A nrPDB 181 2e-46 4X3F-A nrPDB 181 2e-46 3G0E-A nrPDB 181 3e-46 2A1A-B nrPDB 180 4e-46 5UIU-A nrPDB 180 5e-46 5HVK-A nrPDB 180 6e-46 5TQX-A nrPDB 180 6e-46 6FER-A nrPDB 180 7e-46 5GRN-A nrPDB 180 7e-46 4TPT-A nrPDB 178 2e-45 4C59-A nrPDB 178 2e-45 4X7Q-B nrPDB 178 3e-45 3PLS-A nrPDB 178 3e-45 5U6B-A nrPDB 178 4e-45 3UIU-A nrPDB 176 1e-44 5TOS-A nrPDB 176 1e-44 3ZZW-A nrPDB 176 1e-44 2PMN-X nrPDB 176 1e-44 6J5U-C nrPDB 175 2e-44 2RIO-A nrPDB 173 6e-44 5WNL-A nrPDB 173 8e-44 5U6C-A nrPDB 173 9e-44 3M42-A nrPDB 173 1e-43 4PL5-B nrPDB 172 1e-43 5WNO-A nrPDB 172 2e-43 3QUP-A nrPDB 172 2e-43 4FL3-A nrPDB 171 3e-43 4NEU-A nrPDB 171 4e-43 4IDT-A nrPDB 170 7e-43 4Y83-A nrPDB 170 7e-43 3LLT-A nrPDB 170 7e-43 4F9B-A nrPDB 170 9e-43 6HV0-A nrPDB 169 1e-42 5C26-A nrPDB 167 4e-42 3LMG-A nrPDB 166 7e-42 5LPZ-A nrPDB 165 2e-41 4G3E-A nrPDB 165 2e-41 5LPV-A nrPDB 165 3e-41 4LQP-A nrPDB 164 4e-41 3UIM-A nrPDB 163 1e-40 3Q4U-A nrPDB 162 2e-40 4F0G-A nrPDB 161 2e-40 2QKW-B nrPDB 159 1e-39 3MDY-A nrPDB 159 1e-39 4JLC-A nrPDB 159 2e-39 4EUU-A nrPDB 158 2e-39 4EUT-A nrPDB 158 4e-39 2BUJ-A nrPDB 157 7e-39 3SV0-A nrPDB 156 1e-38 2Y4I-B nrPDB 155 2e-38 5TE0-A nrPDB 155 2e-38 6NT9-A nrPDB 155 3e-38 5XD6-A nrPDB 154 3e-38 6O8B-A nrPDB 154 3e-38 3SOC-A nrPDB 154 5e-38 2CHL-A nrPDB 153 8e-38 5AR8-A nrPDB 152 2e-37 2H34-A nrPDB 152 2e-37 3G2F-A nrPDB 151 3e-37 1PY5-A nrPDB 151 3e-37 5IKW-A nrPDB 150 5e-37 6BFN-A nrPDB 150 6e-37 4M66-A nrPDB 149 1e-36 5FQD-C nrPDB 149 1e-36 2CMW-A nrPDB 149 2e-36 4TN6-A nrPDB 149 2e-36 2C47-A nrPDB 148 3e-36 3QD2-B nrPDB 145 2e-35 5E8V-A nrPDB 144 3e-35 2QLU-A nrPDB 144 5e-35 5X18-A nrPDB 144 5e-35 3VHK-A nrPDB 142 2e-34 5VC6-A nrPDB 141 2e-34 4NT4-A nrPDB 140 6e-34 4XHH-A nrPDB 140 8e-34 3HNG-A nrPDB 139 1e-33 4XHL-A nrPDB 138 2e-33 5VDK-A nrPDB 138 2e-33 1CSN-A nrPDB 136 2e-32 5L2Q-C nrPDB 133 1e-31 4BTK-A nrPDB 132 1e-31 4JRN-A nrPDB 132 2e-31 4NFN-A nrPDB 131 3e-31 4RT7-A nrPDB 131 4e-31 5X1R-A nrPDB 129 2e-30 5USZ-A nrPDB 128 4e-30 2PZI-A nrPDB 127 5e-30 4L00-A nrPDB 127 7e-30 4Y12-A nrPDB 125 2e-29 4M69-B nrPDB 123 1e-28 4BTF-A nrPDB 123 1e-28 5M07-A nrPDB 114 5e-26 4IX6-A nrPDB 97 9e-21 4O1O-A nrPDB 81 4e-16 4OAU-C nrPDB 75 3e-14 Sequences not found previously or not previously below threshold: 3ZBF-A nrPDB 171 5e-43 3AOX-A nrPDB 166 1e-41 2WTK-B nrPDB 156 1e-38 3MY0-A nrPDB 154 5e-38 5J0A-A nrPDB 130 8e-31 6DC0-A nrPDB 129 1e-30 5CEK-A nrPDB 129 1e-30 4MWI-A nrPDB 119 2e-27 5C01-A nrPDB 115 2e-26 4WOV-A nrPDB 114 4e-26 4L68-A nrPDB 111 4e-25 3REP-A nrPDB 100 2e-21 4I94-A nrPDB 98 5e-21 5OAT-A nrPDB 97 7e-21 6J6I-B nrPDB 97 7e-21 5UV4-A nrPDB 96 1e-20 6EQI-C nrPDB 93 1e-19 5UU1-A nrPDB 83 1e-16 5CLR-A nrPDB 83 2e-16 2RSV-A nrPDB 81 8e-16 2LAV-A nrPDB 79 2e-15 6G4J-A nrPDB 71 8e-13 4CI6-B nrPDB 68 3e-12 5DMZ-A nrPDB 67 1e-11 6EAS-A nrPDB 66 2e-11 2JII-A nrPDB 59 3e-09 6EWX-A nrPDB 58 7e-09 4AZV-A nrPDB 57 1e-08 4AZW-A nrPDB 56 2e-08 6M7Z-A nrPDB 56 2e-08 5GZ9-A nrPDB 56 3e-08 5GZA-A nrPDB 55 3e-08 3ENH-A nrPDB 55 4e-08 4CYJ-A nrPDB 54 9e-08 6BHC-A nrPDB 51 5e-07 5VE6-A nrPDB 49 2e-06 6G38-A nrPDB 48 3e-06 3Q60-A nrPDB 48 6e-06 4WWA-A nrPDB 48 6e-06 2W1Z-A nrPDB 47 9e-06 4BWP-A nrPDB 47 1e-05 3BYV-A nrPDB 47 1e-05 3DZO-A nrPDB 45 3e-05 4CZY-B nrPDB 42 3e-04 1TQM-A nrPDB 41 6e-04 6FAI-l nrPDB 37 0.010 5YK0-A nrPDB 36 0.027 6G18-v nrPDB 33 0.18 4BVU-A nrPDB 33 0.20 6FDN-A nrPDB 32 0.41 6G5I-z nrPDB 31 0.74 4OTP-A nrPDB 31 0.95 6EF6-A nrPDB 30 1.5 3CNW-A nrPDB 29 1.6 5LJ3-H nrPDB 29 2.1 >4AU8-A nrPDB Length = 296 Score = 410 bits (1053), Expect = e-115, Method: Composition-based stats. Identities = 291/291 (100%), Positives = 291/291 (100%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK Sbjct: 6 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 65 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN 121 NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN Sbjct: 66 NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN 125 Query: 122 VLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYST 181 VLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYST Sbjct: 126 VLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYST 185 Query: 182 SIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPM 241 SIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPM Sbjct: 186 SIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPM 245 Query: 242 YPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 292 YPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP Sbjct: 246 YPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 296 >2BPM-A nrPDB Length = 309 Score = 357 bits (917), Expect = 3e-99, Method: Composition-based stats. Identities = 174/293 (59%), Positives = 216/293 (73%), Gaps = 2/293 (0%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 M+ ++K+EKIGEGTYG V+KA+N+ T E+VALK++RLD + EGVPS+A+REI LLKEL H Sbjct: 6 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 65 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCN-GDLDPEIVKSFLFQLLKGLGFCHS 119 NIV+L DV+H++ KL LVFEF QDLKK+ D+ + ++KS+LFQLL+GL FCHS Sbjct: 66 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 125 Query: 120 RNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLY 179 VLHRDLKPQNLLIN G +KLADFGLARAFG+PVR Y+ EVVTLWYR P++L G K Y Sbjct: 126 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 185 Query: 180 STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPY 239 ST++D+WS GCIFAE+ R LFPG+ DQL RIFR LGTP E WP +T +PDYKP Sbjct: 186 STAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPS 244 Query: 240 PMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 292 A VVP L+ GR LL +L +P +RISA+ AL HP+F D P Sbjct: 245 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP 297 >3NIZ-A nrPDB Length = 311 Score = 346 bits (887), Expect = 1e-95, Method: Composition-based stats. Identities = 169/292 (57%), Positives = 211/292 (72%), Gaps = 3/292 (1%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 M+KY+KLEK+GEGTYG V+KAK+ IVALKR+RLD +DEG+PS+A+REI LLKEL H Sbjct: 20 MEKYQKLEKVGEGTYGVVYKAKD-SQGRIVALKRIRLDAEDEGIPSTAIREISLLKELHH 78 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 NIV L DV+HS++ LTLVFEF ++DLKK D L +K +L+QLL+G+ CH Sbjct: 79 PNIVSLIDVIHSERCLTLVFEFMEKDLKKVLDENKTGLQDSQIKIYLYQLLRGVAHCHQH 138 Query: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYS 180 +LHRDLKPQNLLIN +G LKLADFGLARAFGIPVR Y+ EVVTLWYR PDVL G+K YS Sbjct: 139 RILHRDLKPQNLLINSDGALKLADFGLARAFGIPVRSYTHEVVTLWYRAPDVLMGSKKYS 198 Query: 181 TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPY- 239 TS+D+WS GCIFAE+ G+PLFPG DDQL +IF +LGTP +WP + +LP +K Sbjct: 199 TSVDIWSIGCIFAEMIT-GKPLFPGVTDDDQLPKIFSILGTPNPREWPQVQELPLWKQRT 257 Query: 240 PMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCP 291 +++P G DLL N+L +P +RISA +A+ HPYF D P Sbjct: 258 FQVFEKKPWSSIIPGFCQEGIDLLSNMLCFDPNKRISARDAMNHPYFKDLDP 309 >1V0B-A nrPDB Length = 288 Score = 342 bits (879), Expect = 7e-95, Method: Composition-based stats. Identities = 173/288 (60%), Positives = 214/288 (74%), Gaps = 2/288 (0%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 M+KY LEKIGEGTYG V+KA+N E ALK++RL+ +DEG+PS+ +REI +LKELKH Sbjct: 1 MEKYHGLEKIGEGTYGVVYKAQNNY-GETFALKKIRLEKEDEGIPSTTIREISILKELKH 59 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 NIV+L+DV+H+ K+L LVFE DQDLKK D C G L+ KSFL QLL G+ +CH R Sbjct: 60 SNIVKLYDVIHTKKRLVLVFEHLDQDLKKLLDVCEGGLESVTAKSFLLQLLNGIAYCHDR 119 Query: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYS 180 VLHRDLKPQNLLINR GELK+ADFGLARAFGIPVR Y+ EVVTLWYR PDVL G+K YS Sbjct: 120 RVLHRDLKPQNLLINREGELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVLMGSKKYS 179 Query: 181 TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYP 240 T+ID+WS GCIFAE+ N PLFPG DQL RIFR+LGTP + WP++T+LP Y P Sbjct: 180 TTIDIWSVGCIFAEMVNGA-PLFPGVSEADQLMRIFRILGTPNSKNWPNVTELPKYDPNF 238 Query: 241 MYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288 + + L+ +G DLL +LK +P QRI+A++AL+H YF + Sbjct: 239 TVYEPLPWESFLKGLDESGIDLLSKMLKLDPNQRITAKQALEHAYFKE 286 >6GU6-A nrPDB Length = 302 Score = 338 bits (868), Expect = 2e-93, Method: Composition-based stats. Identities = 165/292 (56%), Positives = 209/292 (71%), Gaps = 3/292 (1%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 M+ Y K+EKIGEGTYG V+K +++ T ++VA+K++RL+ ++EGVPS+A+REI LLKEL+H Sbjct: 6 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 65 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSC--NGDLDPEIVKSFLFQLLKGLGFCH 118 NIV L DVL D +L L+FEF DLKKY DS +D +VKS+L+Q+L+G+ FCH Sbjct: 66 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 125 Query: 119 SRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL 178 SR VLHRDLKPQNLLI+ G +KLADFGLARAFGIP+R Y+ EVVTLWYR P+VL G+ Sbjct: 126 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 185 Query: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKP 238 YST +D+WS G IFAELA +PLF G+ DQL RIFR LGTP E WP + L DYK Sbjct: 186 YSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN 244 Query: 239 YPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFC 290 SL + V L+ G DLL +L +P +RIS + AL HPYF+D Sbjct: 245 TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLD 296 >4KRC-A nrPDB Length = 317 Score = 329 bits (843), Expect = 1e-90, Method: Composition-based stats. Identities = 166/298 (55%), Positives = 213/298 (71%), Gaps = 12/298 (4%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62 ++++LEK+G GTY TV+K N+ T VALK V+LD + EG PS+A+REI L+KELKH+N Sbjct: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSE-EGTPSTAIREISLMKELKHEN 64 Query: 63 IVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCN-----GDLDPEIVKSFLFQLLKGLGFC 117 IVRL+DV+H++ KLTLVFEF D DLKKY DS L+ +VK F +QLL+GL FC Sbjct: 65 IVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFC 124 Query: 118 HSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAK 177 H +LHRDLKPQNLLIN+ G+LKL DFGLARAFGIPV +S+EVVTLWYR PDVL G++ Sbjct: 125 HENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSR 184 Query: 178 LYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYK 237 YSTSID+WS GCI AE+ G+PLFPG + ++QLK IF ++GTP E WPS+TKLP Y Sbjct: 185 TYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYN 243 Query: 238 PYPMYPATTSLVNVV-----PKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFC 290 P L V+ L+ D L LL+ NP R+SA++AL HP+F+++ Sbjct: 244 PNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEYY 301 >1UA2-A nrPDB Length = 346 Score = 315 bits (807), Expect = 2e-86, Method: Composition-based stats. Identities = 134/294 (45%), Positives = 188/294 (63%), Gaps = 5/294 (1%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDE---GVPSSALREICLLKEL 58 ++YEKL+ +GEG + TV+KA+++ T++IVA+K+++L E G+ +ALREI LL+EL Sbjct: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 Query: 59 KHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCH 118 H NI+ L D ++LVF+F + DL+ + L P +K+++ L+GL + H Sbjct: 70 SHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLH 129 Query: 119 SRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL 178 +LHRDLKP NLL++ NG LKLADFGLA++FG P R Y+ +VVT WYR P++LFGA++ Sbjct: 130 QHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARM 189 Query: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKP 238 Y +DMW+ GCI AEL P PG+ DQL RIF LGTPTEEQWP M LPDY Sbjct: 190 YGVGVDMWAVGCILAELL-LRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVT 248 Query: 239 YPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 292 + +P L ++ DL+Q L NP RI+A +AL+ YFS+ P Sbjct: 249 FKSFPG-IPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGP 301 >5G6V-A nrPDB Length = 324 Score = 311 bits (796), Expect = 3e-85, Method: Composition-based stats. Identities = 164/287 (57%), Positives = 211/287 (73%), Gaps = 3/287 (1%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 M+ Y KL+K+GEGTY TV+K K++ T +VALK +RL+ + EG P +A+RE+ LLK+LKH Sbjct: 1 METYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE-EGAPCTAIREVSLLKDLKH 59 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 NIV LHD++H++K LTLVFE+ D+DLK+Y D C ++ VK FLFQLL+GL +CH + Sbjct: 60 ANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQ 119 Query: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYS 180 VLHRDLKPQNLLIN GELKLADFGLARA IP + Y EVVTLWYRPPD+L G+ YS Sbjct: 120 KVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYDNEVVTLWYRPPDILLGSTDYS 179 Query: 181 TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYP 240 T IDMW GCIF E+A GRPLFPG+ V++QL IFR+LGTPTEE WP + ++K Y Sbjct: 180 TQIDMWGVGCIFYEMAT-GRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYN 238 Query: 241 MYPATTS-LVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286 L++ P+L++ G DLL LL+ RISAE+A++HP+F Sbjct: 239 YPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFF 285 >4AGU-A nrPDB Length = 311 Score = 301 bits (771), Expect = 3e-82, Method: Composition-based stats. Identities = 115/290 (39%), Positives = 165/290 (56%), Gaps = 3/290 (1%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 M+KYEK+ KIGEG+YG VFK +NR+T +IVA+K+ +DD + ALREI +LK+LKH Sbjct: 2 MEKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKH 61 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 N+V L +V ++L LVFE+CD + D + +VKS +Q L+ + FCH Sbjct: 62 PNLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFCHKH 121 Query: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYS 180 N +HRD+KP+N+LI ++ +KL DFG AR P Y EV T WYR P++L G Y Sbjct: 122 NCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYDDEVATRWYRSPELLVGDTQYG 181 Query: 181 TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDY--KP 238 +D+W+ GC+FAEL + G PL+PG DQL I + LG + + Sbjct: 182 PPVDVWAIGCVFAELLS-GVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFSGVK 240 Query: 239 YPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288 P L P ++ LL+ L +P +R++ E+ L HPYF + Sbjct: 241 IPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTERLTCEQLLHHPYFEN 290 >3GC0-A nrPDB Length = 329 Score = 298 bits (763), Expect = 2e-81, Method: Composition-based stats. Identities = 151/299 (50%), Positives = 214/299 (71%), Gaps = 10/299 (3%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 + +Y ++ K+GEGTYG V+KA + T+E VA+KR+RL+ ++EGVP +A+RE+ LLKEL+H Sbjct: 33 IDRYRRITKLGEGTYGEVYKAIDTVTNETVAIKRIRLEHEEEGVPGTAIREVSLLKELQH 92 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 +NI+ L V+H + +L L+FE+ + DLKKY D N D+ ++KSFL+QL+ G+ FCHSR Sbjct: 93 RNIIELKSVIHHNHRLHLIFEYAENDLKKYMDK-NPDVSMRVIKSFLYQLINGVNFCHSR 151 Query: 121 NVLHRDLKPQNLLI-----NRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFG 175 LHRDLKPQNLL+ + LK+ DFGLARAFGIP+R ++ E++TLWYRPP++L G Sbjct: 152 RCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQFTHEIITLWYRPPEILLG 211 Query: 176 AKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPD 235 ++ YSTS+D+WS CI+AE+ PLFPG+ DQL +IF +LG P + WP +T LPD Sbjct: 212 SRHYSTSVDIWSIACIWAEMLM-KTPLFPGDSEIDQLFKIFEVLGLPDDTTWPGVTALPD 270 Query: 236 YK-PYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFS--DFCP 291 +K +P + T + L+ G DLL +L+ +PV+RISA+ AL+HPYFS DF P Sbjct: 271 WKQSFPKFRGKTLKRVLGALLDDEGLDLLTAMLEMDPVKRISAKNALEHPYFSHNDFDP 329 >4BBM-A nrPDB Length = 331 Score = 297 bits (762), Expect = 3e-81, Method: Composition-based stats. Identities = 114/289 (39%), Positives = 164/289 (56%), Gaps = 3/289 (1%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 M+KYE L +GEG+YG V K +N++T IVA+K+ DDD+ V A+REI LLK+L+H Sbjct: 24 MEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRH 83 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 +N+V L +V K+ LVFEF D + + LD ++V+ +LFQ++ G+GFCHS Sbjct: 84 ENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIGFCHSH 143 Query: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYS 180 N++HRD+KP+N+L++++G +KL DFG AR P Y EV T WYR P++L G Y Sbjct: 144 NIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYDDEVATRWYRAPELLVGDVKYG 203 Query: 181 TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYK--P 238 ++D+W+ GC+ E+ PLFPG+ DQL I LG K P + Sbjct: 204 KAVDVWAIGCLVTEMFMGE-PLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGVR 262 Query: 239 YPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFS 287 P L PKL+ DL + L +P +R E L H +F Sbjct: 263 LPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQ 311 >5EFQ-A nrPDB Length = 347 Score = 297 bits (760), Expect = 5e-81, Method: Composition-based stats. Identities = 119/303 (39%), Positives = 183/303 (60%), Gaps = 13/303 (4%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 + K++ + IGEGTYG V+KA++++T E+VALK+VRLD++ EG P +A+REI +L++L H Sbjct: 10 VDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTH 69 Query: 61 KNIVRLHDVLHSDKK----------LTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQL 110 ++I+ + +++ + LVFE+ D DL +S + +KSF+ QL Sbjct: 70 QSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQL 129 Query: 111 LKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAF-GIPVRCYSAEVVTLWYRP 169 ++GL +CH +N LHRD+K N+L+N G++KLADFGLAR + R Y+ +V+TLWYRP Sbjct: 130 MEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRP 189 Query: 170 PDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPS 229 P++L G + Y+ +ID+WS GCI EL +P+F N QL+ I R+ G+P WP Sbjct: 190 PELLLGEERYTPAIDVWSCGCILGELFT-KKPIFQANQELAQLELISRICGSPCPAVWPD 248 Query: 230 MTKLPDYKP-YPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288 + KLP + P L + A DL +L +P +R +AE+ALQ + D Sbjct: 249 VIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRD 308 Query: 289 FCP 291 P Sbjct: 309 VEP 311 >4NST-A nrPDB Length = 351 Score = 297 bits (760), Expect = 5e-81, Method: Composition-based stats. Identities = 121/309 (39%), Positives = 186/309 (60%), Gaps = 18/309 (5%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 + K++ + IGEGTYG V+KAK+++T E+VALK+VRLD++ EG P +A+REI +L++L H Sbjct: 12 VDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIH 71 Query: 61 KNIVRLHDVLHSDKK----------LTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQL 110 +++V + +++ + LVFE+ D DL +S + +KSF+ QL Sbjct: 72 RSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQL 131 Query: 111 LKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAF-GIPVRCYSAEVVTLWYRP 169 ++GL +CH +N LHRD+K N+L+N +G++KLADFGLAR + R Y+ +V+TLWYRP Sbjct: 132 MEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRP 191 Query: 170 PDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPS 229 P++L G + Y+ +ID+WS GCI EL +P+F N QL+ I RL G+P WP Sbjct: 192 PELLLGEERYTPAIDVWSCGCILGELFT-KKPIFQANLELAQLELISRLCGSPCPAVWPD 250 Query: 230 MTKLPDYKP-YPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288 + KLP + P L + + DLL ++L +P +R +AE+ LQ + D Sbjct: 251 VIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKD 310 Query: 289 -----FCPP 292 PP Sbjct: 311 VELSKMAPP 319 >5Z33-A nrPDB Length = 425 Score = 291 bits (746), Expect = 2e-79, Method: Composition-based stats. Identities = 114/301 (37%), Positives = 162/301 (53%), Gaps = 13/301 (4%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELK-H 60 ++Y +++G+G YG V A N +T E VA+K+V + + ALREI LL+ + H Sbjct: 31 ERYTVTKELGQGAYGIVCAAVNNQTSEGVAIKKVTNVFSKKILAKRALREIKLLQHFRGH 90 Query: 61 KNIVRLHDV----LHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGF 116 +NI L+D+ + + L E + DL S L +SF++Q+L GL + Sbjct: 91 RNITCLYDMDIPRPDNFNETYLYEELMECDLAAIIRS-GQPLTDAHFQSFIYQILCGLKY 149 Query: 117 CHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRC----YSAEVVTLWYRPPDV 172 HS NVLHRDLKP NLL+N + ELK+ DFGLAR F + + V T WYR P++ Sbjct: 150 IHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSVDPEENAGYMTEYVATRWYRAPEI 209 Query: 173 LFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMT- 231 + + Y+ +ID+WS GCI AEL GRP F G D DQL +I +LGTP EE + Sbjct: 210 MLSFQSYTKAIDVWSVGCILAELL-GGRPFFKGRDYVDQLNQILHILGTPNEETLSRIGS 268 Query: 232 -KLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFC 290 + +Y + A + P N DLL +L +P RIS E+AL+HPY + Sbjct: 269 PRAQEYVRNLPFMAKKPFPTLFPNANPDALDLLDRMLAFDPSSRISVEQALEHPYLHIWH 328 Query: 291 P 291 Sbjct: 329 D 329 >4EWQ-A nrPDB Length = 383 Score = 291 bits (745), Expect = 2e-79, Method: Composition-based stats. Identities = 104/299 (34%), Positives = 154/299 (51%), Gaps = 14/299 (4%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 ++Y+ L +G G YG+V A + +T VA+K++ RE+ LLK +KH+ Sbjct: 45 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 104 Query: 62 NIVRLHDVL------HSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLG 115 N++ L DV + LV DL L + V+ ++Q+L+GL Sbjct: 105 NVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK--LTDDHVQFLIYQILRGLK 162 Query: 116 FCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFG 175 + HS +++HRDLKP NL +N + ELK+ DFGLAR + V T WYR P+++ Sbjct: 163 YIHSADIIHRDLKPSNLAVNEDCELKILDFGLARH---TDDEMTGYVATRWYRAPEIMLN 219 Query: 176 AKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMT--KL 233 Y+ ++D+WS GCI AEL GR LFPG D DQLK I RL+GTP E ++ Sbjct: 220 WMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESA 278 Query: 234 PDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 292 +Y + NV N DLL+ +L + +RI+A +AL H YF+ + P Sbjct: 279 RNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDP 337 >1G3N-A nrPDB Length = 326 Score = 291 bits (745), Expect = 2e-79, Method: Composition-based stats. Identities = 135/298 (45%), Positives = 183/298 (61%), Gaps = 15/298 (5%) Query: 2 QKYEKLEKIGEGTYGTVFKAKN-RETHEIVALKRVRLDDDDEGVPSSALREICLLKELK- 59 Q+YE + +IGEG YG VFKA++ + VALKRVR+ +EG+P S +RE+ +L+ L+ Sbjct: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 Query: 60 --HKNIVRLHDVLH-----SDKKLTLVFEFCDQDLKKYFDSC-NGDLDPEIVKSFLFQLL 111 H N+VRL DV + KLTLVFE DQDL Y D + E +K +FQLL Sbjct: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130 Query: 112 KGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPD 171 +GL F HS V+HRDLKPQN+L+ +G++KLADFGLAR + + ++ VVTLWYR P+ Sbjct: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQM-ALTSVVVTLWYRAPE 189 Query: 172 VLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMT 231 VL + Y+T +D+WS GCIFAE+ +PLF G+ DQL +I ++G P EE WP Sbjct: 190 VLLQSS-YATPVDLWSVGCIFAEMF-RRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDV 247 Query: 232 KLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDF 289 LP + + + V ++ G+DLL L NP +RISA AL HPYF D Sbjct: 248 ALPRQAFHS--KSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDL 303 >2F9G-A nrPDB Length = 353 Score = 285 bits (731), Expect = 1e-77, Method: Composition-based stats. Identities = 113/309 (36%), Positives = 165/309 (53%), Gaps = 24/309 (7%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62 ++ +GEG YG V A ++ T EIVA+K++ D LREI +LK KH+N Sbjct: 12 DFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI-EPFDKPLFALRTLREIKILKHFKHEN 70 Query: 63 IVRLH-----DVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFC 117 I+ + D + ++ ++ E DL + + L + ++ F++Q L+ + Sbjct: 71 IITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQ--MLSDDHIQYFIYQTLRAVKVL 128 Query: 118 HSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPV----------RCYSAEVVTLWY 167 H NV+HRDLKP NLLIN N +LK+ DFGLAR + V T WY Sbjct: 129 HGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWY 188 Query: 168 RPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQW 227 R P+V+ + YS ++D+WS GCI AEL RP+FPG D QL IF ++GTP + Sbjct: 189 RAPEVMLTSAKYSRAMDVWSCGCILAELF-LRRPIFPGRDYRHQLLLIFGIIGTPHSDND 247 Query: 228 PSMTKLPDYKPY----PMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQH 283 + P + Y PMYPA L + P++N G DLLQ +L +P +RI+A+EAL+H Sbjct: 248 LRCIESPRAREYIKSLPMYPAA-PLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEH 306 Query: 284 PYFSDFCPP 292 PY + P Sbjct: 307 PYLQTYHDP 315 >3OHT-A nrPDB Length = 389 Score = 285 bits (730), Expect = 2e-77, Method: Composition-based stats. Identities = 101/299 (33%), Positives = 154/299 (51%), Gaps = 14/299 (4%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 ++Y+ L +G G YG+V + + ++ +A+K++ RE+ LLK +KH+ Sbjct: 51 ERYQTLSPVGSGAYGSVCSSYDVKSGLKIAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 110 Query: 62 NIVRLHDVL------HSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLG 115 N++ L DV + LV DL L + V+ ++Q+L+GL Sbjct: 111 NVIGLLDVFTPATSLEEFNDVYLVTHLMGADLNNIVKCQK--LTDDHVQFLIYQILRGLK 168 Query: 116 FCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFG 175 + HS +++HRDLKP NL +N + ELK+ DFGLAR + V T WYR P+++ Sbjct: 169 YIHSADIIHRDLKPSNLAVNEDCELKILDFGLARH---TDDEMTGYVATRWYRAPEIMLN 225 Query: 176 AKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSM--TKL 233 Y+ ++D+WS GCI AEL GR LFPG D +QL++I RL GTP M + Sbjct: 226 WMHYNMTVDIWSVGCIMAELLT-GRTLFPGTDHINQLQQIMRLTGTPPASVISRMPSHEA 284 Query: 234 PDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 292 +Y + +V N DLL+ +L + +RI+A EAL HPYFS + P Sbjct: 285 RNYINSLPQMPKRNFADVFIGANPLAVDLLEKMLVLDTDKRITASEALAHPYFSQYHDP 343 >3MIA-A nrPDB Length = 351 Score = 284 bits (728), Expect = 2e-77, Method: Composition-based stats. Identities = 122/307 (39%), Positives = 175/307 (57%), Gaps = 18/307 (5%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 + KYEKL KIG+GT+G VFKA++R+T + VALK+V ++++ EG P +ALREI +L+ LKH Sbjct: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75 Query: 61 KNIVRLHDVLHSD--------KKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLK 112 +N+V L ++ + + LVF+FC+ DL + +K + LL Sbjct: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLN 135 Query: 113 GLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRC----YSAEVVTLWYR 168 GL + H +LHRD+K N+LI R+G LKLADFGLARAF + Y+ VVTLWYR Sbjct: 136 GLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYR 195 Query: 169 PPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWP 228 PP++L G + Y ID+W AGCI AE+ P+ GN QL I +L G+ T E WP Sbjct: 196 PPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALISQLCGSITPEVWP 254 Query: 229 SMTKLPDYKPYPMYPATTSLVNVVPKL---NATGRDLLQNLLKCNPVQRISAEEALQHPY 285 ++ Y+ + V K + DL+ LL +P QRI +++AL H + Sbjct: 255 NVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDF 314 Query: 286 FSDFCPP 292 F + P Sbjct: 315 F--WSDP 319 >4QTB-A nrPDB Length = 380 Score = 284 bits (727), Expect = 3e-77, Method: Composition-based stats. Identities = 109/300 (36%), Positives = 163/300 (54%), Gaps = 14/300 (4%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62 +Y +L+ IGEG YG V A + VA+K++ + + LREI +L +H+N Sbjct: 42 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLRFRHEN 100 Query: 63 IVRLHDVL-----HSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFC 117 ++ + D+L + + + +V + + DL K S L + + FL+Q+L+GL + Sbjct: 101 VIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQ--LSNDHICYFLYQILRGLKYI 158 Query: 118 HSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCY---SAEVVTLWYRPPDVLF 174 HS NVLHRDLKP NLLIN +LK+ DFGLAR + V T WYR P+++ Sbjct: 159 HSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIML 218 Query: 175 GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLP 234 +K Y+ SID+WS GCI AE+ + RP+FPG DQL I +LG+P++E + + Sbjct: 219 NSKGYTKSIDIWSVGCILAEMLSN-RPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMK 277 Query: 235 DYKPYPMYPATTS--LVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 292 P+ T + PK ++ DLL +L NP +RI+ EEAL HPY + P Sbjct: 278 ARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDP 337 >5NGU-A nrPDB Length = 381 Score = 283 bits (725), Expect = 5e-77, Method: Composition-based stats. Identities = 106/300 (35%), Positives = 160/300 (53%), Gaps = 14/300 (4%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62 +Y L IGEG YG V A + VA+K++ + + LREI +L +H+N Sbjct: 43 RYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKIS-PFEHQTYCQRTLREIKILLRFRHEN 101 Query: 63 IVRLHDVL-----HSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFC 117 I+ ++D++ K + +V + + DL K + + L + + FL+Q+L+GL + Sbjct: 102 IIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQH--LSNDHICYFLYQILRGLKYI 159 Query: 118 HSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCY---SAEVVTLWYRPPDVLF 174 HS NVLHRDLKP NLL+N +LK+ DFGLAR + V T WYR P+++ Sbjct: 160 HSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIML 219 Query: 175 GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLP 234 +K Y+ SID+WS GCI AE+ + RP+FPG DQL I +LG+P++E + L Sbjct: 220 NSKGYTKSIDIWSVGCILAEMLSN-RPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLK 278 Query: 235 --DYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 292 +Y + + P ++ DLL +L NP +RI E+AL HPY + P Sbjct: 279 ARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDP 338 >1CM8-A nrPDB Length = 367 Score = 281 bits (719), Expect = 2e-76, Method: Composition-based stats. Identities = 103/296 (34%), Positives = 154/296 (52%), Gaps = 14/296 (4%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 Y L+ +G G YG V A + T VA+K++ E A RE+ LLK ++H+N+ Sbjct: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 Query: 64 VRLHDVLHSDKKL------TLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFC 117 + L DV D+ L LV F DL K + L + ++ ++Q+LKGL + Sbjct: 87 IGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMK--HEKLGEDRIQFLVYQMLKGLRYI 144 Query: 118 HSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAK 177 H+ ++HRDLKP NL +N + ELK+ DFGLAR + VVT WYR P+V+ Sbjct: 145 HAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE---MTGYVVTRWYRAPEVILNWM 201 Query: 178 LYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEE--QWPSMTKLPD 235 Y+ ++D+WS GCI AE+ G+ LF G+D DQLK I ++ GTP E Q + + Sbjct: 202 RYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKN 260 Query: 236 YKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCP 291 Y +++ + +LL+ +L + QR++A EAL HPYF Sbjct: 261 YMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHD 316 >3GC9-A nrPDB Length = 370 Score = 280 bits (716), Expect = 6e-76, Method: Composition-based stats. Identities = 105/299 (35%), Positives = 153/299 (51%), Gaps = 14/299 (4%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 Q+ + L +G G YG+V A + + VA+K++ RE+ LLK LKH+ Sbjct: 28 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHE 87 Query: 62 NIVRLHDVL------HSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLG 115 N++ L DV ++ LV DL S L E V+ ++QLL+GL Sbjct: 88 NVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKSQ--ALSDEHVQFLVYQLLRGLK 145 Query: 116 FCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFG 175 + HS ++HRDLKP N+ +N + EL++ DFGLAR + V T WYR P+++ Sbjct: 146 YIHSAGIIHRDLKPSNVAVNEDSELRILDFGLARQAD---EEMTGYVATRWYRAPEIMLN 202 Query: 176 AKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPD 235 Y+ ++D+WS GCI AEL G+ LFPG+D DQLKRI ++GTP+ E ++ Sbjct: 203 WMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHA 261 Query: 236 YKPYPMYP--ATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 292 P L ++ N DLL +L + QR+SA EAL H YFS + P Sbjct: 262 RTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDP 320 >4IC8-A nrPDB Length = 442 Score = 280 bits (716), Expect = 6e-76, Method: Composition-based stats. Identities = 106/303 (34%), Positives = 155/303 (51%), Gaps = 14/303 (4%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 +YE +E IG G YG V A+ R T + VA+K++ D LRE+ +LK KH Sbjct: 55 DEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHD 114 Query: 62 NIVRLHDV------LHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLG 115 NI+ + D+ K + +V + + DL + S L E V+ FL+QLL+GL Sbjct: 115 NIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQ-PLTLEHVRYFLYQLLRGLK 173 Query: 116 FCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAF----GIPVRCYSAEVVTLWYRPPD 171 + HS V+HRDLKP NLL+N N ELK+ DFG+AR + V T WYR P+ Sbjct: 174 YMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPE 233 Query: 172 VLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSM- 230 ++ Y+ +ID+WS GCIF E+ + LFPG + QL+ I +LGTP+ ++ Sbjct: 234 LMLSLHEYTQAIDLWSVGCIFGEMLARRQ-LFPGKNYVHQLQLIMMVLGTPSPAVIQAVG 292 Query: 231 -TKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDF 289 ++ Y V P + LL +L+ P RISA AL+HP+ + + Sbjct: 293 AERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKY 352 Query: 290 CPP 292 P Sbjct: 353 HDP 355 >4BGQ-A nrPDB Length = 304 Score = 280 bits (716), Expect = 7e-76, Method: Composition-based stats. Identities = 120/291 (41%), Positives = 171/291 (58%), Gaps = 6/291 (2%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 M K+E L +GEG YG V K +++ETHEIVA+K+ + +++E V + LRE+ +L+ LK Sbjct: 11 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 70 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 +NIV L + KL LVFE+ ++++ + + + PE VKS+++QL+K + +CH Sbjct: 71 ENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKN 130 Query: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRC-YSAEVVTLWYRPPDVLFGAKLY 179 +++HRD+KP+NLLI+ N LKL DFG AR Y EV T WYR P++L GA Y Sbjct: 131 DIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYDEEVATRWYRSPELLLGA-PY 189 Query: 180 STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDY--K 237 S+DMWS GCI EL + G+PLFPG DQL I ++LG EQ P + Sbjct: 190 GKSVDMWSVGCILGEL-SDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGL 248 Query: 238 PYPMYPATTSLVNVVPK-LNATGRDLLQNLLKCNPVQRISAEEALQHPYFS 287 +P SL LN+ DL++NLLK +P R E+ L HP F Sbjct: 249 RFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQ 299 >6DTL-A nrPDB Length = 364 Score = 279 bits (715), Expect = 9e-76, Method: Composition-based stats. Identities = 113/296 (38%), Positives = 168/296 (56%), Gaps = 10/296 (3%) Query: 3 KYEK-LEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 KY+ + IG+G YG V A N ET+E VA+K++ D++ LREI LL+ + H+ Sbjct: 30 KYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHE 89 Query: 62 NIVRLHDVLHSD-----KKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGF 116 NIV + D++ + + +E D DL + S N L E + FL+Q+L+GL + Sbjct: 90 NIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRS-NQALSEEHCQYFLYQILRGLKY 148 Query: 117 CHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGA 176 HS NVLHRDLKP NLL+N N +LK+ DFGLAR + VVT WYR P++L + Sbjct: 149 IHSANVLHRDLKPSNLLLNANCDLKICDFGLAR-VTSESDFMTEYVVTRWYRAPELLLNS 207 Query: 177 KLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKL-PD 235 Y+ +ID+WS GCIF EL + +PLFPG D QL+ + L+GTP+EE+ + + Sbjct: 208 SDYTAAIDVWSVGCIFMELMD-RKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKR 266 Query: 236 YKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCP 291 Y S+ + P ++ DL++ +L +P +RI+ +AL HPY + Sbjct: 267 YIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHD 322 >3OZ6-A nrPDB Length = 388 Score = 279 bits (714), Expect = 9e-76, Method: Composition-based stats. Identities = 109/334 (32%), Positives = 171/334 (51%), Gaps = 45/334 (13%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELK- 59 ++KYE ++K+G+G YG V+K+ +R T E+VA+K++ + REI +L EL Sbjct: 8 LRKYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIFDAFQNSTDAQRTFREIMILTELSG 67 Query: 60 HKNIVRLHDVLH--SDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFC 117 H+NIV L +VL +D+ + LVF++ + DL + L+P + ++QL+K + + Sbjct: 68 HENIVNLLNVLRADNDRDVYLVFDYMETDLHAVIRAN--ILEPVHKQYVVYQLIKVIKYL 125 Query: 118 HSRNVLHRDLKPQNLLINRNGELKLADFGLARA---------------------FGIPVR 156 HS +LHRD+KP N+L+N +K+ADFGL+R+ F Sbjct: 126 HSGGLLHRDMKPSNILLNAECHVKVADFGLSRSFVNIRRVTNNIPLSINENTENFDDDQP 185 Query: 157 CYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIF 216 + V T WYR P++L G+ Y+ IDMWS GCI E+ G+P+FPG+ +QL+RI Sbjct: 186 ILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILC-GKPIFPGSSTMNQLERII 244 Query: 217 RLLGTPTEEQWPSMTK------------------LPDYKPYPMYPATTSLVNVVPKLNAT 258 ++ P+ E S+ + + +N N Sbjct: 245 GVIDFPSNEDVESIQSPFAKTMIESLKEKVEIRQSNKRDIFTKWKNLLLKINPKADCNEE 304 Query: 259 GRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 292 DLL LL+ NP +RISA +AL+HP+ S F P Sbjct: 305 ALDLLDKLLQFNPNKRISANDALKHPFVSIFHNP 338 >2W96-B nrPDB Length = 306 Score = 279 bits (714), Expect = 1e-75, Method: Composition-based stats. Identities = 132/293 (45%), Positives = 180/293 (61%), Gaps = 14/293 (4%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELK--- 59 +YE + +IG G YGTV+KA++ + VALK VR+ + +EG+P S +RE+ LL+ L+ Sbjct: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGLPISTVREVALLRRLEAFE 64 Query: 60 HKNIVRLHDVLHSDK-----KLTLVFEFCDQDLKKYFDSCNGD-LDPEIVKSFLFQLLKG 113 H N+VRL DV + + K+TLVFE DQDL+ Y D L E +K + Q L+G Sbjct: 65 HPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRG 124 Query: 114 LGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVL 173 L F H+ ++HRDLKP+N+L+ G +KLADFGLAR + + VVTLWYR P+VL Sbjct: 125 LDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQM-ALDPVVVTLWYRAPEVL 183 Query: 174 FGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKL 233 + Y+T +DMWS GCIFAE+ +PLF GN DQL +IF L+G P E+ WP L Sbjct: 184 LQS-TYATPVDMWSVGCIFAEMF-RRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSL 241 Query: 234 PDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286 P P P + +VVP++ +G LL +L NP +RISA ALQH Y Sbjct: 242 PRGAFPPRGP--RPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL 292 >4QNY-A nrPDB Length = 354 Score = 279 bits (714), Expect = 1e-75, Method: Composition-based stats. Identities = 96/299 (32%), Positives = 152/299 (50%), Gaps = 11/299 (3%) Query: 2 QKYEKLEKIGEGTYGTVFKAKN-RETHEIVALKRVRLDDDDEGV-PSSALREICLLKELK 59 +Y IG G+YG V +A++ + + +VA+KRV + +E + LREI LL Sbjct: 20 DRYLLERIIGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFEEVILAKRILREIKLLAHFN 79 Query: 60 HKNIVRLHDVLHSDK-----KLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGL 114 NI+ L ++L + +V + + DLK+ S +L ++ F++Q L+ L Sbjct: 80 DDNIIGLRNILTPEDPENFDHFYIVMDIMETDLKQVLRS-GQELTEAHIQFFIYQALRAL 138 Query: 115 GFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLF 174 HS V+HRD+ P N+L+N N +LK+ DFGLA+ + V WYR P+++ Sbjct: 139 HIIHSAGVIHRDITPANILVNTNCDLKICDFGLAKEENDQGEYMTDYVTMRWYRAPELVM 198 Query: 175 GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSM--TK 232 K YS ID+W GCI EL RPLF G D +QL +I ++GTP+EE S+ + Sbjct: 199 EDKDYSAQIDVWGIGCILGELL-GSRPLFQGKDRVNQLDKIVDVIGTPSEEDINSVGSSA 257 Query: 233 LPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCP 291 Y + P + DLL+++L NP +RI+ +A++HP+ Sbjct: 258 AQKYLKKKSHRPQADWRQRYPTASPEALDLLRHMLVFNPKRRITVLQAMRHPFLEQLHD 316 >3ZDU-A nrPDB Length = 325 Score = 278 bits (712), Expect = 2e-75, Method: Composition-based stats. Identities = 102/289 (35%), Positives = 159/289 (55%), Gaps = 4/289 (1%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 M+ YE L K+GEG+YGTV K K++ T +IVA+K + ++ V A+REI LK+ H Sbjct: 2 MEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIF-YERPEQSVNKIAMREIKFLKQFHH 60 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 +N+V L +V KK+ LVFEF D + L+ + ++ +LFQ+L+ + + HS Sbjct: 61 ENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSN 120 Query: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYS 180 N++HRD+KP+N+L++++G KL DFG AR P Y EV T WYR P+++ Y Sbjct: 121 NIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYDDEVATRWYRAPELVLKDTSYG 180 Query: 181 TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKP-- 238 +D+W+ GC+ E+A G P P + D L +I +G + +K P + Sbjct: 181 KPVDIWALGCMIIEMAT-GNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGVV 239 Query: 239 YPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFS 287 P + PKLN D++ L+ +P RIS+ + L H YF+ Sbjct: 240 LPQVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYFT 288 >4MYG-A nrPDB Length = 372 Score = 277 bits (710), Expect = 3e-75, Method: Composition-based stats. Identities = 100/291 (34%), Positives = 151/291 (51%), Gaps = 15/291 (5%) Query: 10 IGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDV 69 +G G YG+V A ++ + E VA+K++ E A RE+ LLK ++H+N++ L DV Sbjct: 51 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 110 Query: 70 LHSDKKL------TLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVL 123 L LV F DL+K + E ++ ++Q+LKGL + HS V+ Sbjct: 111 FTPASSLRNFYDFYLVMPFMQTDLQKIM---GMEFSEEKIQYLVYQMLKGLKYIHSAGVV 167 Query: 124 HRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSI 183 HRDLKP NL +N + ELK+ DFGLAR + VVT WYR P+V+ Y+ ++ Sbjct: 168 HRDLKPGNLAVNEDCELKILDFGLARHADAE---MTGYVVTRWYRAPEVILSWMHYNQTV 224 Query: 184 DMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTK--LPDYKPYPM 241 D+WS GCI AE+ G+ LF G D DQL +I ++ G P E + Y Sbjct: 225 DIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLP 283 Query: 242 YPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 292 + P+ + DLL+ +L+ + +R++A +AL HP+F F P Sbjct: 284 QTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDP 334 >4ZSG-A nrPDB Length = 347 Score = 275 bits (705), Expect = 1e-74, Method: Composition-based stats. Identities = 106/303 (34%), Positives = 155/303 (51%), Gaps = 14/303 (4%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 +YE +E IG G YG V A+ R T + VA+K++ D LRE+ +LK KH Sbjct: 7 DEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHD 66 Query: 62 NIVRLHDV------LHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLG 115 NI+ + D+ K + +V + + DL + S L E V+ FL+QLL+GL Sbjct: 67 NIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQ-PLTLEHVRYFLYQLLRGLK 125 Query: 116 FCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAF----GIPVRCYSAEVVTLWYRPPD 171 + HS V+HRDLKP NLL+N N ELK+ DFG+AR + V T WYR P+ Sbjct: 126 YMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPE 185 Query: 172 VLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSM- 230 ++ Y+ +ID+WS GCIF E+ + LFPG + QL+ I +LGTP+ ++ Sbjct: 186 LMLSLHEYTQAIDLWSVGCIFGEMLARRQ-LFPGKNYVHQLQLIMMVLGTPSPAVIQAVG 244 Query: 231 -TKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDF 289 ++ Y V P + LL +L+ P RISA AL+HP+ + + Sbjct: 245 AERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKY 304 Query: 290 CPP 292 P Sbjct: 305 HDP 307 >3NCG-A nrPDB Length = 486 Score = 273 bits (699), Expect = 5e-74, Method: Composition-based stats. Identities = 79/291 (27%), Positives = 135/291 (46%), Gaps = 32/291 (10%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 ++Y + +G+G++G V K K+R T + A+K + S+ LRE+ LLK+L H Sbjct: 22 ERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKLDHP 81 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN 121 NI++L ++L +V E + Q+ G+ + H N Sbjct: 82 NIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMHKHN 141 Query: 122 VLHRDLKPQNLLI---NRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL 178 ++HRDLKP+N+L+ ++ ++K+ DFGL+ F + + T +Y P+VL G Sbjct: 142 IVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTK-MKDRIGTAYYIAPEVLRGT-- 198 Query: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKP 238 Y D+WSAG I L + G P F G + D LKR+ E LP ++ Sbjct: 199 YDEKCDVWSAGVILYILLS-GTPPFYGKNEYDILKRV---------ETGKYAFDLPQWRT 248 Query: 239 YPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDF 289 ++ +DL++ +L +P RI+A + L+HP+ + Sbjct: 249 ----------------ISDDAKDLIRKMLTFHPSLRITATQCLEHPWIQKY 283 >5JN2-A nrPDB Length = 525 Score = 273 bits (698), Expect = 8e-74, Method: Composition-based stats. Identities = 76/293 (25%), Positives = 131/293 (44%), Gaps = 33/293 (11%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRV-RLDDDDEGVPSSALREICLLKELKH 60 +Y+ +G+G++G V K++ T + A+K + + + S LRE+ LLK+L H Sbjct: 67 DRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDH 126 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 NI++L++ LV E + Q+L G+ + H Sbjct: 127 PNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKN 186 Query: 121 NVLHRDLKPQNLLI---NRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAK 177 ++HRDLKP+NLL+ +++ +++ DFGL+ F + ++ T +Y P+VL G Sbjct: 187 KIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEA-SKKMKDKIGTAYYIAPEVLHGT- 244 Query: 178 LYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYK 237 Y D+WS G I L + P F G + D LK++ + T QW Sbjct: 245 -YDEKCDVWSTGVILYILLSGC-PPFNGANEYDILKKVEKGKYTFELPQWK--------- 293 Query: 238 PYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFC 290 K++ + +DL++ +L P RISA +AL H + + Sbjct: 294 ----------------KVSESAKDLIRKMLTYVPSMRISARDALDHEWIQTYT 330 >3LIJ-A nrPDB Length = 494 Score = 272 bits (696), Expect = 1e-73, Method: Composition-based stats. Identities = 78/292 (26%), Positives = 135/292 (46%), Gaps = 32/292 (10%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 + Y++++K+G G YG V +++ TH A+K +R S L E+ +LK L H Sbjct: 37 EMYQRVKKLGSGAYGEVLLCRDKVTHVERAIKIIRKTSVSTSSNSKLLEEVAVLKLLDHP 96 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN 121 NI++L+D + LV E + + Q+L G+ + H N Sbjct: 97 NIMKLYDFFEDKRNYYLVMECYKGGELFDEIIHRMKFNEVDAAVIIKQVLSGVTYLHKHN 156 Query: 122 VLHRDLKPQNLLI---NRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL 178 ++HRDLKP+NLL+ ++ +K+ DFGL+ F + + T +Y P+VL K Sbjct: 157 IVHRDLKPENLLLESKEKDALIKIVDFGLSAVFENQ-KKMKERLGTAYYIAPEVL--RKK 213 Query: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKP 238 Y D+WS G I L G P F G + L+++ + T +W ++ Sbjct: 214 YDEKCDVWSIGVILFILLA-GYPPFGGQTDQEILRKVEKGKYTFDSPEWKNV-------- 264 Query: 239 YPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFC 290 + +DL++ +L+ + +RISA++AL+HP+ + C Sbjct: 265 -----------------SEGAKDLIKQMLQFDSQRRISAQQALEHPWIKEMC 299 >1JNK-A nrPDB Length = 423 Score = 272 bits (696), Expect = 1e-73, Method: Composition-based stats. Identities = 101/311 (32%), Positives = 155/311 (49%), Gaps = 25/311 (8%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 +++Y+ L+ IG G G V A + VA+K++ ++ A RE+ L+K + H Sbjct: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120 Query: 61 KNIVRLHDVLHSDKKL------TLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGL 114 KNI+ L +V K L LV E D +L + +LD E + L+Q+L G+ Sbjct: 121 KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI---QMELDHERMSYLLYQMLCGI 177 Query: 115 GFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLF 174 HS ++HRDLKP N+++ + LK+ DFGLAR G + VVT +YR P+V+ Sbjct: 178 KHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF-MMTPYVVTRYYRAPEVIL 236 Query: 175 GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMT-KL 233 G Y ++D+WS GCI E+ + LFPG D DQ ++ LGTP E + + Sbjct: 237 GM-GYKENVDIWSVGCIMGEMV-RHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTV 294 Query: 234 PDYKPYPMYPATTSLVNVVPK------------LNATGRDLLQNLLKCNPVQRISAEEAL 281 +Y A + + P + RDLL +L +P +RIS ++AL Sbjct: 295 RNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDAL 354 Query: 282 QHPYFSDFCPP 292 QHPY + + P Sbjct: 355 QHPYINVWYDP 365 >2XS0-A nrPDB Length = 386 Score = 271 bits (694), Expect = 2e-73, Method: Composition-based stats. Identities = 102/311 (32%), Positives = 153/311 (49%), Gaps = 25/311 (8%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 +++Y+ L+ IG G G V A + VA+K++ ++ A RE+ L+K + H Sbjct: 25 LKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 84 Query: 61 KNIVRLHDVLHSDKKL------TLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGL 114 KNI+ L +V K L +V E D +L + +LD E + L+Q+L G+ Sbjct: 85 KNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVI---QMELDHERMSYLLYQMLCGI 141 Query: 115 GFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLF 174 HS ++HRDLKP N+++ + LK+ DFGLAR G VVT +YR P+V+ Sbjct: 142 KHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF-MMVPFVVTRYYRAPEVIL 200 Query: 175 GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMT-KL 233 G Y ++D+WS GCI E+ G LFPG D DQ ++ LGTP E + + Sbjct: 201 GM-GYKENVDIWSVGCIMGEMIKGGV-LFPGTDHIDQWNKVIEQLGTPCPEFMKKLQPTV 258 Query: 234 PDYKPYPMYPATTSLVNVVPKL------------NATGRDLLQNLLKCNPVQRISAEEAL 281 Y A S + P + + RDLL +L + +RIS +EAL Sbjct: 259 RTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEAL 318 Query: 282 QHPYFSDFCPP 292 QHPY + + P Sbjct: 319 QHPYINVWYDP 329 >5AWM-A nrPDB Length = 394 Score = 271 bits (693), Expect = 3e-73, Method: Composition-based stats. Identities = 100/309 (32%), Positives = 148/309 (47%), Gaps = 26/309 (8%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62 +Y L IG G G V A + T + VA+K++ + A RE L+K + HKN Sbjct: 45 RYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKN 104 Query: 63 IVRLHDVLHSDKKL------TLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGF 116 I+ L + + L LV E D +L + DLD + + L+Q+L G+ Sbjct: 105 IIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVI---QMDLDHDRMSYLLYQMLCGIKH 161 Query: 117 CHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGA 176 HS ++HRDLKP N+++ + LK+ DFGLAR G + VVT +YR P+V+ G Sbjct: 162 LHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTF-MMTPYVVTRYYRAPEVILG- 219 Query: 177 KLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTE------------ 224 Y+ ++D+WS GCI E+ G LFPG D DQ +I LGTP+ Sbjct: 220 MGYTENVDIWSVGCIMGEMIRGGV-LFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRN 278 Query: 225 --EQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQ 282 E P T + +P + + R+LL +L +P QRIS +EAL+ Sbjct: 279 YVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALK 338 Query: 283 HPYFSDFCP 291 H Y + + Sbjct: 339 HEYINVWYD 347 >4MVF-A nrPDB Length = 506 Score = 270 bits (692), Expect = 4e-73, Method: Composition-based stats. Identities = 84/292 (28%), Positives = 139/292 (47%), Gaps = 34/292 (11%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 KY EK+G+GTYG V+K ++ T+++ A+K + D +EI ++K+L H Sbjct: 57 DKYIIDEKLGQGTYGCVYKGIDKVTNQLYAIKEEKKDRLKNINR--FFQEIEIMKKLDHP 114 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN 121 NIV+L++ +D + L+ E C NG + + + Q+ + + HS N Sbjct: 115 NIVKLYETYENDNYIYLIMELCSGRELFDSIIENGSFTEKNAATIMKQIFSAIFYLHSLN 174 Query: 122 VLHRDLKPQNLLI---NRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL 178 ++HRDLKP+N L N++ LK+ DFGL++ G + + T +Y P VL G Sbjct: 175 IVHRDLKPENFLFQSENKDSLLKIIDFGLSKNLG-TGEFTTTKAGTPYYVAPQVLDGK-- 231 Query: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKP 238 Y D+WS+G I L G P F G+ ++ LK++ + E W S Sbjct: 232 YDKKCDIWSSGVIMYTLLC-GYPPFYGDTDNEVLKKVKKGEFCFYENDWGS--------- 281 Query: 239 YPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFC 290 +++ ++L+ LL NP +R + EEAL HP+ + Sbjct: 282 ----------------ISSDAKNLITKLLTYNPNERCTIEEALNHPWITQMT 317 >3DFA-A nrPDB Length = 286 Score = 270 bits (692), Expect = 4e-73, Method: Composition-based stats. Identities = 79/291 (27%), Positives = 135/291 (46%), Gaps = 32/291 (10%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 ++Y + +G+G++G V K K+R T + A+K + S+ LRE+ LLK+L H Sbjct: 22 ERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKLDHP 81 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN 121 NI++L ++L +V E + Q+ G+ + H N Sbjct: 82 NIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMHKHN 141 Query: 122 VLHRDLKPQNLLI---NRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL 178 ++HRDLKP+N+L+ ++ ++K+ DFGL+ F + + T +Y P+VL G Sbjct: 142 IVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTK-MKDRIGTAYYIAPEVLRGT-- 198 Query: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKP 238 Y D+WSAG I L + G P F G + D LKR+ E LP ++ Sbjct: 199 YDEKCDVWSAGVILYILLS-GTPPFYGKNEYDILKRV---------ETGKYAFDLPQWRT 248 Query: 239 YPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDF 289 ++ +DL++ +L +P RI+A + L+HP+ + Sbjct: 249 ----------------ISDDAKDLIRKMLTFHPSLRITATQCLEHPWIQKY 283 >3HZT-A nrPDB Length = 467 Score = 269 bits (688), Expect = 1e-72, Method: Composition-based stats. Identities = 82/293 (27%), Positives = 131/293 (44%), Gaps = 33/293 (11%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSAL-REICLLKELKH 60 +Y++++K+G G YG V K++ T A+K ++ S AL E+ +LK+L H Sbjct: 4 DRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDH 63 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 NI++L++ + LV E + Q+L G + H Sbjct: 64 PNIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLSGTTYLHKH 123 Query: 121 NVLHRDLKPQNLLI---NRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAK 177 N++HRDLKP+NLL+ +R+ +K+ DFGL+ F + + + T +Y P+VL K Sbjct: 124 NIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGK-MKERLGTAYYIAPEVL--RK 180 Query: 178 LYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYK 237 Y D+WS G I L G P F G + LKR+ + + W + Sbjct: 181 KYDEKCDVWSCGVILYILLC-GYPPFGGQTDQEILKRVEKGKFSFDPPDWTQV------- 232 Query: 238 PYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFC 290 + + L++ +L P +RISAEEAL HP+ FC Sbjct: 233 ------------------SDEAKQLVKLMLTYEPSKRISAEEALNHPWIVKFC 267 >3E7O-A nrPDB Length = 360 Score = 269 bits (687), Expect = 1e-72, Method: Composition-based stats. Identities = 99/311 (31%), Positives = 155/311 (49%), Gaps = 25/311 (8%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 +++Y++L+ IG G G V A + VA+K++ ++ A RE+ LLK + H Sbjct: 21 LKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNH 80 Query: 61 KNIVRLHDVLHSDKKL------TLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGL 114 KNI+ L +V K L LV E D +L + + +LD E + L+Q+L G+ Sbjct: 81 KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI---HMELDHERMSYLLYQMLCGI 137 Query: 115 GFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLF 174 HS ++HRDLKP N+++ + LK+ DFGLAR + VVT +YR P+V+ Sbjct: 138 KHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTASTNF-MMTPYVVTRYYRAPEVIL 196 Query: 175 GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMT-KL 233 G Y ++D+WS GCI EL +F G D DQ ++ LGTP+ E ++ + Sbjct: 197 GM-GYKENVDIWSVGCIMGELVKGSV-IFQGTDHIDQWNKVIEQLGTPSAEFMAALQPTV 254 Query: 234 PDYKPYPMYPATTSLVNVVPKL------------NATGRDLLQNLLKCNPVQRISAEEAL 281 +Y + + P + RDLL +L +P +RIS +EAL Sbjct: 255 RNYVENRPAYPGIAFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEAL 314 Query: 282 QHPYFSDFCPP 292 +HPY + + P Sbjct: 315 RHPYITVWYDP 325 >3DXN-A nrPDB Length = 287 Score = 266 bits (681), Expect = 7e-72, Method: Composition-based stats. Identities = 82/293 (27%), Positives = 131/293 (44%), Gaps = 33/293 (11%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSAL-REICLLKELKH 60 +Y++++K+G G YG V K++ T A+K ++ S AL E+ +LK+L H Sbjct: 21 DRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDH 80 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 NI++L++ + LV E + Q+L G + H Sbjct: 81 PNIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLSGTTYLHKH 140 Query: 121 NVLHRDLKPQNLLI---NRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAK 177 N++HRDLKP+NLL+ +R+ +K+ DFGL+ F + + + T +Y P+VL K Sbjct: 141 NIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGK-MKERLGTAYYIAPEVL--RK 197 Query: 178 LYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYK 237 Y D+WS G I L G P F G + LKR+ + + W + Sbjct: 198 KYDEKCDVWSCGVILYILLC-GYPPFGGQTDQEILKRVEKGKFSFDPPDWTQV------- 249 Query: 238 PYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFC 290 + + L++ +L P +RISAEEAL HP+ FC Sbjct: 250 ------------------SDEAKQLVKLMLTYEPSKRISAEEALNHPWIVKFC 284 >3MA6-A nrPDB Length = 298 Score = 266 bits (681), Expect = 7e-72, Method: Composition-based stats. Identities = 76/293 (25%), Positives = 131/293 (44%), Gaps = 33/293 (11%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRV-RLDDDDEGVPSSALREICLLKELKH 60 +Y+ +G+G++G V K++ T + A+K + + + S LRE+ LLK+L H Sbjct: 32 DRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDH 91 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 NI++L++ LV E + Q+L G+ + H Sbjct: 92 PNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKN 151 Query: 121 NVLHRDLKPQNLLI---NRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAK 177 ++HRDLKP+NLL+ +++ +++ DFGL+ F + ++ T +Y P+VL G Sbjct: 152 KIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEA-SKKMKDKIGTAYYIAPEVLHGT- 209 Query: 178 LYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYK 237 Y D+WS G I L + P F G + D LK++ + T QW Sbjct: 210 -YDEKCDVWSTGVILYILLSGC-PPFNGANEYDILKKVEKGKYTFELPQWK--------- 258 Query: 238 PYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFC 290 K++ + +DL++ +L P RISA +AL H + + Sbjct: 259 ----------------KVSESAKDLIRKMLTYVPSMRISARDALDHEWIQTYT 295 >3FI2-A nrPDB Length = 353 Score = 265 bits (679), Expect = 1e-71, Method: Composition-based stats. Identities = 100/309 (32%), Positives = 154/309 (49%), Gaps = 25/309 (8%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 +++Y+ L+ IG G G V A + VA+K++ ++ A RE+ L+K + H Sbjct: 23 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 82 Query: 61 KNIVRLHDVLHSDKKL------TLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGL 114 KNI+ L +V K L LV E D +L + +LD E + L+Q+L G+ Sbjct: 83 KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI---QMELDHERMSYLLYQMLCGI 139 Query: 115 GFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLF 174 HS ++HRDLKP N+++ + LK+ DFGLAR G + VVT +YR P+V+ Sbjct: 140 KHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF-MMTPYVVTRYYRAPEVIL 198 Query: 175 GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMT-KL 233 G Y ++D+WS GCI E+ + LFPG D DQ ++ LGTP E + + Sbjct: 199 GM-GYKENVDIWSVGCIMGEMV-RHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTV 256 Query: 234 PDYKPYPMYPATTSLVNVVPK------------LNATGRDLLQNLLKCNPVQRISAEEAL 281 +Y A + + P + RDLL +L +P +RIS ++AL Sbjct: 257 RNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDAL 316 Query: 282 QHPYFSDFC 290 QHPY + + Sbjct: 317 QHPYINVWY 325 >5AIR-A nrPDB Length = 430 Score = 263 bits (672), Expect = 7e-71, Method: Composition-based stats. Identities = 99/299 (33%), Positives = 158/299 (52%), Gaps = 18/299 (6%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 Y + IG G++G V++AK ++ E+VA+K+V D + RE+ ++++L H NI Sbjct: 66 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN------RELQIMRKLDHCNI 119 Query: 64 VRLHDVLHSDK------KLTLVFEFCDQDLKK---YFDSCNGDLDPEIVKSFLFQLLKGL 114 VRL +S L LV ++ + + + ++ L VK +++QL + L Sbjct: 120 VRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 179 Query: 115 GFCHSRNVLHRDLKPQNLLINRN-GELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVL 173 + HS + HRD+KPQNLL++ + LKL DFG A+ + + + + +YR P+++ Sbjct: 180 AYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQL-VRGEPNVSYICSRYYRAPELI 238 Query: 174 FGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKL 233 FGA Y++SID+WSAGC+ AEL G+P+FPG+ DQL I ++LGTPT EQ M Sbjct: 239 FGATDYTSSIDVWSAGCVLAELL-LGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPN 297 Query: 234 PDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 292 +P A P+ L LL+ P R++ EA H +F + P Sbjct: 298 YTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDP 356 >3RP9-A nrPDB Length = 458 Score = 260 bits (665), Expect = 5e-70, Method: Composition-based stats. Identities = 111/351 (31%), Positives = 165/351 (47%), Gaps = 65/351 (18%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 +YE IG G+YG V +A ++ +VA+K++ +D LREI +L L H Sbjct: 53 DRYEIRHLIGTGSYGHVCEAYDKLEKRVVAIKKILRVFEDLIDCKRILREIAILNRLNHD 112 Query: 62 NIVRLHDVL-----HSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGF 116 ++V++ D++ +L +V E D D KK F + L +K+ L+ LL G+ + Sbjct: 113 HVVKVLDIVIPKDVEKFDELYVVLEIADSDFKKLFRTP-VYLTELHIKTLLYNLLVGVKY 171 Query: 117 CHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPV--------------------- 155 HS +LHRDLKP N L+N++ +K+ DFGLAR P Sbjct: 172 VHSAGILHRDLKPANCLVNQDCSVKVCDFGLARTVDYPENGNSQLPISPREDDMNLVTFP 231 Query: 156 ------RCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANA----------G 199 R + VVT WYR P+++ + Y+ +ID+WS GCIFAEL N Sbjct: 232 HTKNLKRQLTGHVVTRWYRAPELILLQENYTEAIDVWSIGCIFAELLNMIKENVAYHADR 291 Query: 200 RPLFPGND--------------------VDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPY 239 PLFPG+ DQL IF +LGTP+EE ++ K + Sbjct: 292 GPLFPGSSCFPLSPDQKAGNDFKFHTRGNRDQLNVIFNILGTPSEEDIEALEKEDAKRYI 351 Query: 240 PMYPAT--TSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288 ++P T L P +A LL+ +L NP +RI+ E L HP+F + Sbjct: 352 RIFPKREGTDLAERFPASSADAIHLLKRMLVFNPNKRITINECLAHPFFKE 402 >3N9X-A nrPDB Length = 432 Score = 259 bits (663), Expect = 8e-70, Method: Composition-based stats. Identities = 115/343 (33%), Positives = 168/343 (48%), Gaps = 57/343 (16%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 Y IG G+YG V+ A ++ T + VA+K+V +D LREI +L LK Sbjct: 26 DNYIIKHLIGRGSYGYVYLAYDKNTEKNVAIKKVNRMFEDLIDCKRILREITILNRLKSD 85 Query: 62 NIVRLHDVLHSDK-----KLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGF 116 I+RL+D++ D +L +V E D DLKK F + L E +K+ L+ LL G F Sbjct: 86 YIIRLYDLIIPDDLLKFDELYIVLEIADSDLKKLFKTP-IFLTEEHIKTILYNLLLGENF 144 Query: 117 CHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIP---------------------- 154 H ++HRDLKP N L+N++ +K+ DFGLAR Sbjct: 145 IHESGIIHRDLKPANCLLNQDCSVKVCDFGLARTINSEKDTNIVNDLEENEEPGPHNKNL 204 Query: 155 VRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELA----------NAGRPLFP 204 + ++ VVT WYR P+++ + Y+ SID+WS GCIFAEL PLFP Sbjct: 205 KKQLTSHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAELLNMLQSHINDPTNRFPLFP 264 Query: 205 GN-----------------DVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTS 247 G+ DQL IF ++GTPTE+ ++ K K ++P Sbjct: 265 GSSCFPLSPDRNSKKVHEKSNRDQLNIIFNIIGTPTEDDLKNINKPEVIKYIKLFPHRKP 324 Query: 248 --LVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288 L P ++ G +LL+++LK NP +RI+ ++AL HPY D Sbjct: 325 INLKQKYPSISDDGINLLESMLKFNPNKRITIDQALDHPYLKD 367 >2VN9-A nrPDB Length = 301 Score = 259 bits (663), Expect = 8e-70, Method: Composition-based stats. Identities = 76/290 (26%), Positives = 118/290 (40%), Gaps = 30/290 (10%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 +Y+ E++G+G + V + T + A K + RE + + LKH Sbjct: 4 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 63 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN 121 NIVRLHD + + LVF+ + Q+L+ + CH Sbjct: 64 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNG 123 Query: 122 VLHRDLKPQNLLI---NRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL 178 ++HRDLKP+NLL+ ++ +KLADFGLA + + T Y P+VL Sbjct: 124 IVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVL-RKDP 182 Query: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKP 238 Y +DMW+ G I L G P F D ++I +W ++T Sbjct: 183 YGKPVDMWACGVILYILLV-GYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVT------- 234 Query: 239 YPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288 +DL+ +L NP +RI+A EAL+HP+ Sbjct: 235 ------------------PEAKDLINKMLTINPAKRITASEALKHPWICQ 266 >4O2Z-A nrPDB Length = 377 Score = 259 bits (662), Expect = 1e-69, Method: Composition-based stats. Identities = 97/296 (32%), Positives = 152/296 (51%), Gaps = 9/296 (3%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62 KY L+ +G G YG + +T E V++K+ R D LREI +++ H+N Sbjct: 46 KYTLLKILGMGAYGIACSCLDGDTGEKVSIKKCRDVFRDVEDGKRVLREIDMMRFFHHEN 105 Query: 63 IVRLHDV-------LHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLG 115 ++ + ++ HS + + +V D D+ S L+ ++ F++Q+L+GL Sbjct: 106 LLNVVNILPPLKREYHSFEDVYVVTPLMDVDMNVVLRSRQ-VLEESHMQYFVYQILRGLK 164 Query: 116 FCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFG 175 + HS NV HRDLKP NL+ N + ELK+ DFGL+R+ +P + V+T WYRPP++L Sbjct: 165 YLHSANVAHRDLKPANLVTNISCELKIIDFGLSRSVDVPYSELTDYVITRWYRPPELLLE 224 Query: 176 AKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPD 235 YST++D+WS GCIFAE+ N +P+FPG + DQL+ I + +G P L Sbjct: 225 NTNYSTAVDIWSVGCIFAEMYN-RKPVFPGRNTMDQLRMIAQHIGKPPASIVEHREALEK 283 Query: 236 YKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCP 291 P + N G D L + +P +R +A + L HPY + Sbjct: 284 LNELPDGSLNIPKLVPGLAGNTEGIDFLSKMWTLDPSKRPTAADMLAHPYLAHLHD 339 >5FG8-A nrPDB Length = 285 Score = 257 bits (658), Expect = 3e-69, Method: Composition-based stats. Identities = 75/290 (25%), Positives = 117/290 (40%), Gaps = 30/290 (10%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 Y+ E++G+G + V + + T A K + RE + ++L H Sbjct: 14 DNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHHP 73 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN 121 NIVRLHD + + LVF+ + Q+L+ + CH Sbjct: 74 NIVRLHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQNG 133 Query: 122 VLHRDLKPQNLLINRNGE---LKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL 178 V+HRDLKP+NLL+ + +KLADFGLA + + T Y P+VL + Sbjct: 134 VVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVL-KKEP 192 Query: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKP 238 Y S+D+W+ G I L G P F D +I +W ++T Sbjct: 193 YGKSVDIWACGVILYILLV-GYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVT------- 244 Query: 239 YPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288 ++L+ +L NP +RI+A EAL+HP+ Sbjct: 245 ------------------PEAKNLINQMLTVNPNKRITAAEALKHPWICQ 276 >5ES1-A nrPDB Length = 328 Score = 257 bits (657), Expect = 5e-69, Method: Composition-based stats. Identities = 68/284 (23%), Positives = 130/284 (45%), Gaps = 31/284 (10%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 Y L IG+G + V A++ T VA+K + + RE+ ++K L H NI Sbjct: 17 YRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNI 76 Query: 64 VRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVL 123 V+L +V+ ++K L LV E+ + +G + + ++ Q++ + +CH +N++ Sbjct: 77 VKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIV 136 Query: 124 HRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSI 183 HRDLK +NLL++ +K+ADFG + F + + + Y P++ G K + Sbjct: 137 HRDLKAENLLLDAEANIKIADFGFSNEFTLGSK-LDTFCGSPPYAAPELFQGKKYDGPEV 195 Query: 184 DMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYP 243 D+WS G I L + P F G+++ + +R+ R ++P Y Sbjct: 196 DIWSLGVILYTLVSGSLP-FDGHNLKELRERVLR-----------GKYRVPFY------- 236 Query: 244 ATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFS 287 ++ +L+ L NP +R + E+ ++ + + Sbjct: 237 -----------MSTDCESILRRFLVLNPAKRCTLEQIMKDKWIN 269 >4YZB-A nrPDB Length = 491 Score = 256 bits (654), Expect = 8e-69, Method: Composition-based stats. Identities = 74/290 (25%), Positives = 128/290 (44%), Gaps = 33/290 (11%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRV-RLDDDDEGVPSSALREICLLKELKH 60 +Y+ +G+G++G V K++ T + A+K + + + L+E+ LLK+L H Sbjct: 30 DRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTDKELLLKEVELLKKLDH 89 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 NI++L++ LV E + Q+L G+ + H Sbjct: 90 PNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKN 149 Query: 121 NVLHRDLKPQNLLIN---RNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAK 177 ++HRDLKP+NLL+ ++ +++ DFGL+ F + ++ T +Y P+VL G Sbjct: 150 KIVHRDLKPENLLLENKRKDANIRIIDFGLSTHF-ESTKKMKDKIGTAYYIAPEVLHGT- 207 Query: 178 LYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYK 237 Y D+WS G I L + P F G + D LK++ + T QW Sbjct: 208 -YDEKCDVWSTGVILYILLSGC-PPFNGANEFDILKKVEKGKFTFDLPQWK--------- 256 Query: 238 PYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFS 287 K++ +DL++ +L P RISA +AL+H + Sbjct: 257 ----------------KVSEPAKDLIRKMLAYVPTMRISARDALEHEWLK 290 >3NIE-A nrPDB Length = 429 Score = 255 bits (653), Expect = 1e-68, Method: Composition-based stats. Identities = 114/346 (32%), Positives = 166/346 (47%), Gaps = 60/346 (17%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 YE IG G+YG V+ A ++ ++ VA+K+V +D LREI +L LK Sbjct: 28 DNYEIKHLIGRGSYGYVYLAYDKNANKNVAIKKVNRMFEDLIDCKRILREITILNRLKSD 87 Query: 62 NIVRLHDVLHSDK-----KLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGF 116 I+RLHD++ + +L +V E D DLKK F + L + VK+ L+ LL G F Sbjct: 88 YIIRLHDLIIPEDLLKFDELYIVLEIADSDLKKLFKTP-IFLTEQHVKTILYNLLLGEKF 146 Query: 117 CHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIP---------------------- 154 H ++HRDLKP N L+N++ +K+ DFGLAR Sbjct: 147 IHESGIIHRDLKPANCLLNQDCSVKICDFGLARTINSDKDIHIVNDLEEKEENEEPGPHN 206 Query: 155 ---VRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELA----------NAGRP 201 + ++ VVT WYR P+++ + Y+ SID+WS GCIFAEL P Sbjct: 207 KNLKKQLTSHVVTRWYRAPELILLQENYTNSIDIWSTGCIFAELLNMMKSHINNPTNRFP 266 Query: 202 LFPGN-----------------DVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPA 244 LFPG+ DQL IF ++GTP EE +TK K ++P Sbjct: 267 LFPGSSCFPLSPDHNSKKVHEKSNRDQLNIIFNVIGTPPEEDLKCITKQEVIKYIKLFPT 326 Query: 245 TT--SLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288 L ++ G DLL+++L+ N +RI+ ++AL HPY D Sbjct: 327 RDGIDLSKKYSSISKEGIDLLESMLRFNAQKRITIDKALSHPYLKD 372 >2QNJ-A nrPDB Length = 328 Score = 255 bits (653), Expect = 1e-68, Method: Composition-based stats. Identities = 68/284 (23%), Positives = 132/284 (46%), Gaps = 31/284 (10%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 Y L+ IG+G + V A++ T VA+K + + RE+ ++K L H NI Sbjct: 14 YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNI 73 Query: 64 VRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVL 123 V+L +V+ ++K L L+ E+ + +G + + +S Q++ + +CH + ++ Sbjct: 74 VKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIV 133 Query: 124 HRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSI 183 HRDLK +NLL++ + +K+ADFG + F + + + Y P++ G K + Sbjct: 134 HRDLKAENLLLDADMNIKIADFGFSNEFTVGGK-LDTFCGSPPYAAPELFQGKKYDGPEV 192 Query: 184 DMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYP 243 D+WS G I L + P F G ++ + +R+ R ++P Y Sbjct: 193 DVWSLGVILYTLVSGSLP-FDGQNLKELRERVLR-----------GKYRIPFY------- 233 Query: 244 ATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFS 287 ++ +LL+ L NP++R + E+ ++ + + Sbjct: 234 -----------MSTDCENLLKRFLVLNPIKRGTLEQIMKDRWIN 266 >5U6Y-A nrPDB Length = 461 Score = 255 bits (652), Expect = 2e-68, Method: Composition-based stats. Identities = 75/287 (26%), Positives = 116/287 (40%), Gaps = 30/287 (10%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 Y+ E++G+G + V + + A K + RE + + LKH NI Sbjct: 2 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 61 Query: 64 VRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVL 123 VRLHD + + L+F+ + Q+L+ + CH V+ Sbjct: 62 VRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVV 121 Query: 124 HRDLKPQNLLIN---RNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYS 180 HRDLKP+NLL+ + +KLADFGLA + + T Y P+VL Y Sbjct: 122 HRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVL-RKDPYG 180 Query: 181 TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYP 240 +D+W+ G I L G P F D ++I +W ++T Sbjct: 181 KPVDLWACGVILYILLV-GYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVT--------- 230 Query: 241 MYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFS 287 +DL+ +L NP +RI+A EAL+HP+ S Sbjct: 231 ----------------PEAKDLINKMLTINPSKRITAAEALKHPWIS 261 >3COM-A nrPDB Length = 314 Score = 255 bits (651), Expect = 2e-68, Method: Composition-based stats. Identities = 74/285 (25%), Positives = 134/285 (47%), Gaps = 33/285 (11%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 ++ LEK+GEG+YG+V+KA ++ET +IVA+K+V ++ D ++EI ++++ ++ Sbjct: 31 FDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESD----LQEIIKEISIMQQCDSPHV 86 Query: 64 VRLHDVLHSDKKLTLVFEFCD-QDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNV 122 V+ + + L +V E+C + N L + + + L LKGL + H Sbjct: 87 VKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRK 146 Query: 123 LHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTS 182 +HRD+K N+L+N G KLADFG+A + + + T ++ P+V+ Y+ Sbjct: 147 IHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI-QEIGYNCV 205 Query: 183 IDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMY 242 D+WS G E+A P ++ IF + P P ++ ++ Sbjct: 206 ADIWSLGITAIEMAEGKPPY----ADIHPMRAIFMIPTNPP----------PTFRKPELW 251 Query: 243 PATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFS 287 + D ++ L +P QR +A + LQHP+ Sbjct: 252 -------------SDNFTDFVKQCLVKSPEQRATATQLLQHPFVR 283 >5IG1-A nrPDB Length = 344 Score = 254 bits (649), Expect = 3e-68, Method: Composition-based stats. Identities = 77/291 (26%), Positives = 126/291 (43%), Gaps = 31/291 (10%) Query: 5 EKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIV 64 +K IG+G + TV + N+ T E+ A+K + L + REI + L+H++IV Sbjct: 20 DKRSVIGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRSSEINKIKREIGICSSLQHEHIV 79 Query: 65 RLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLH 124 + + LVFE+ + + + + Q+L L CHS+N++H Sbjct: 80 SMRRAFRDESHFYLVFEYVSGGELFDEIVTRKFYNEKDASACMHQILSALQHCHSKNIIH 139 Query: 125 RDLKPQNLLI---NRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYST 181 RDLKP+NLL+ + N +K+ DFGLA Y T Y P+V+ Y T Sbjct: 140 RDLKPENLLLASKDPNAPVKITDFGLAVIMEQ-GPTYFGFAGTPGYLSPEVIRRV-PYDT 197 Query: 182 SIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPM 241 ++D+W+ G I L G P F D +I +W S+T Sbjct: 198 AVDVWACGVILYILLV-GYPPFWEEDHQKLYAQIKNCQYDFPSPEWDSVTT--------- 247 Query: 242 YPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 292 ++L++ +L+ NP +R + +E LQHP+ + P Sbjct: 248 ----------------AAKELIKAMLEPNPKRRPTVQELLQHPWIARRDVP 282 >4REW-A nrPDB Length = 540 Score = 254 bits (649), Expect = 4e-68, Method: Composition-based stats. Identities = 74/292 (25%), Positives = 128/292 (43%), Gaps = 32/292 (10%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDE-GVPSSALREICLLKELK 59 + Y + +G GT+G V K+ T VA+K + V REI LK + Sbjct: 5 IGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFR 64 Query: 60 HKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 H +I++L+ V+ + + +V E+ + NG LD + + Q+L G+ +CH Sbjct: 65 HPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHR 124 Query: 120 RNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLY 179 V+HRDLKP+N+L++ + K+ADFGL+ + Y P+V+ G Sbjct: 125 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS-DGEFLRTSCGSPNYAAPEVISGRLYA 183 Query: 180 STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPY 239 +D+WS+G I L P DD + +F+ + + P Y Sbjct: 184 GPEVDIWSSGVILYALLCGTLPF-----DDDHVPTLFKKI-------CDGIFYTPQY--- 228 Query: 240 PMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCP 291 LN + LL+++L+ +P++R S ++ +H +F P Sbjct: 229 ---------------LNPSVISLLKHMLQVDPMKRASIKDIREHEWFKQDLP 265 >2V7O-A nrPDB Length = 336 Score = 253 bits (648), Expect = 5e-68, Method: Composition-based stats. Identities = 71/290 (24%), Positives = 117/290 (40%), Gaps = 30/290 (10%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 Y+ E++G+G + V + + + A K + RE + + LKH Sbjct: 31 DDYQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 90 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN 121 NIVRLHD + + LVF+ + Q+L+ + H + Sbjct: 91 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHD 150 Query: 122 VLHRDLKPQNLLINRNGE---LKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL 178 ++HRDLKP+NLL+ + +KLADFGLA + + T Y P+VL Sbjct: 151 IVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVL-RKDP 209 Query: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKP 238 Y +D+W+ G I L G P F D ++I +W ++T Sbjct: 210 YGKPVDIWACGVILYILLV-GYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVT------- 261 Query: 239 YPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288 ++L+ +L NP +RI+A++AL+HP+ Sbjct: 262 ------------------PEAKNLINQMLTINPAKRITADQALKHPWVCQ 293 >2BDW-A nrPDB Length = 362 Score = 253 bits (648), Expect = 5e-68, Method: Composition-based stats. Identities = 72/290 (24%), Positives = 120/290 (41%), Gaps = 31/290 (10%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 Y+ E++G+G + V + ++ T A K + RE + ++L+H Sbjct: 29 DNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQHP 88 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN 121 NIVRLHD + + LVF+ + Q+L+ + +CHS Sbjct: 89 NIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCHSNG 148 Query: 122 VLHRDLKPQNLLINRNGE---LKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL 178 ++HR+LKP+NLL+ + +KLADFGLA + T Y P+VL Sbjct: 149 IVHRNLKPENLLLASKAKGAAVKLADFGLAIEVN-DSEAWHGFAGTPGYLSPEVL-KKDP 206 Query: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKP 238 YS +D+W+ G I L G P F D +I +W ++T Sbjct: 207 YSKPVDIWACGVILYILLV-GYPPFWDEDQHRLYAQIKAGAYDYPSPEWDTVT------- 258 Query: 239 YPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288 + L+ ++L NP +RI+A++AL+ P+ + Sbjct: 259 ------------------PEAKSLIDSMLTVNPKKRITADQALKVPWICN 290 >4E7W-A nrPDB Length = 394 Score = 253 bits (647), Expect = 6e-68, Method: Composition-based stats. Identities = 102/296 (34%), Positives = 162/296 (54%), Gaps = 19/296 (6%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 Y + IG G++G VF+AK E+ E VA+K+V D + RE+ +++ +KH N+ Sbjct: 42 YTNCKVIGNGSFGVVFQAKLVESDE-VAIKKVLQDKRFKN------RELQIMRIVKHPNV 94 Query: 64 VRLHDVLHSDKK------LTLVFEFCDQDLKK---YFDSCNGDLDPEIVKSFLFQLLKGL 114 V L +S+ L LV E+ + + + ++ + ++K +++QLL+ L Sbjct: 95 VDLKAFFYSNGDKKDEVFLNLVLEYVPETVYRASRHYAKLKQTMPMLLIKLYMYQLLRSL 154 Query: 115 GFCHSRNVLHRDLKPQNLLINR-NGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVL 173 + HS + HRD+KPQNLL++ +G LKL DFG A+ I + + + +YR P+++ Sbjct: 155 AYIHSIGICHRDIKPQNLLLDPPSGVLKLIDFGSAKIL-IAGEPNVSYICSRYYRAPELI 213 Query: 174 FGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKL 233 FGA Y+T+ID+WS GC+ AEL G+PLFPG DQL I ++LGTP+ EQ +M Sbjct: 214 FGATNYTTNIDIWSTGCVMAELMQ-GQPLFPGESGIDQLVEIIKVLGTPSREQIKTMNPN 272 Query: 234 PDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDF 289 +P P+ DL+ LL+ P R++A EAL HP+F + Sbjct: 273 YMEHKFPQIRPHPFSKVFRPRTPPDAIDLISRLLEYTPSARLTAIEALCHPFFDEL 328 >5YKS-A nrPDB Length = 377 Score = 253 bits (647), Expect = 6e-68, Method: Composition-based stats. Identities = 76/290 (26%), Positives = 133/290 (45%), Gaps = 33/290 (11%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 Y+ + +G G + V A++ T E VA+K + D +E+ +K ++H NI Sbjct: 37 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHPNI 96 Query: 64 VRLHDVLHSDKKLTLVFEFCD-QDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNV 122 VRL++V+ + KL L+ E D D+ Y L+ ++ K + Q++ + +CH +V Sbjct: 97 VRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLHV 156 Query: 123 LHRDLKPQN-LLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYST 181 +HRDLKP+N + + G +KL DFG + F P + + +L Y P++L G + + Sbjct: 157 VHRDLKPENVVFFEKQGLVKLTDFGFSNKF-QPGKKLTTSCGSLAYSAPEILLGDEYDAP 215 Query: 182 SIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPM 241 ++D+WS G I + G+P F + + L I T Sbjct: 216 AVDIWSLGVILF-MLVCGQPPFQEANDSETLTMIMDCKYT-------------------- 254 Query: 242 YPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCP 291 V ++ +DL+ +L+ +P +R S EE HP+ P Sbjct: 255 ---------VPSHVSKECKDLITRMLQRDPKRRASLEEIENHPWLQGVDP 295 >5KZ7-A nrPDB Length = 346 Score = 253 bits (647), Expect = 6e-68, Method: Composition-based stats. Identities = 68/287 (23%), Positives = 130/287 (45%), Gaps = 31/287 (10%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 Y L+ IG+G + V A++ T + VA+K + + RE+ ++K L H NI Sbjct: 35 YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNI 94 Query: 64 VRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVL 123 V+L +V+ ++K L LV E+ + +G + + ++ Q++ + +CH + ++ Sbjct: 95 VKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIV 154 Query: 124 HRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSI 183 HRDLK +NLL++ + +K+ADFG + F + Y P++ G K + Sbjct: 155 HRDLKAENLLLDADMNIKIADFGFSNEFTF-GNKLDTFCGSPPYAAPELFQGKKYDGPEV 213 Query: 184 DMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYP 243 D+WS G I L + P F G ++ + +R+ R ++P Y Sbjct: 214 DVWSLGVILYTLVSGSLP-FDGQNLKELRERVLR-----------GKYRIPFY------- 254 Query: 244 ATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFC 290 ++ +LL+ L NP +R + E+ ++ + + Sbjct: 255 -----------MSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGH 290 >2VZ6-A nrPDB Length = 313 Score = 253 bits (646), Expect = 9e-68, Method: Composition-based stats. Identities = 75/287 (26%), Positives = 116/287 (40%), Gaps = 30/287 (10%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 Y+ E++G+G + V + + A K + RE + + LKH NI Sbjct: 24 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 83 Query: 64 VRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVL 123 VRLHD + + L+F+ + Q+L+ + CH V+ Sbjct: 84 VRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVV 143 Query: 124 HRDLKPQNLLIN---RNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYS 180 HRDLKP+NLL+ + +KLADFGLA + + T Y P+VL Y Sbjct: 144 HRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVL-RKDPYG 202 Query: 181 TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYP 240 +D+W+ G I L G P F D ++I +W ++T Sbjct: 203 KPVDLWACGVILYILLV-GYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVT--------- 252 Query: 241 MYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFS 287 +DL+ +L NP +RI+A EAL+HP+ S Sbjct: 253 ----------------PEAKDLINKMLTINPSKRITAAEALKHPWIS 283 >3Q5I-A nrPDB Length = 504 Score = 252 bits (645), Expect = 9e-68, Method: Composition-based stats. Identities = 78/302 (25%), Positives = 125/302 (41%), Gaps = 43/302 (14%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDD-----------EGVPSSALR 50 + Y K+ K+G G YG V K + H A+K ++ D E Sbjct: 36 ESYFKVRKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYSDDNKNIEKFHEEIYN 95 Query: 51 EICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQL 110 EI LLK L H NI++L DV K LV EF + D + + Q+ Sbjct: 96 EISLLKSLDHPNIIKLFDVFEDKKYFYLVTEFYEGGELFEQIINRHKFDECDAANIMKQI 155 Query: 111 LKGLGFCHSRNVLHRDLKPQNLLINRNG---ELKLADFGLARAFGIPVRCYSAEVVTLWY 167 L G+ + H N++HRD+KP+N+L+ +K+ DFGL+ F + + T +Y Sbjct: 156 LSGICYLHKHNIVHRDIKPENILLENKNSLLNIKIVDFGLSSFFSKDYK-LRDRLGTAYY 214 Query: 168 RPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQW 227 P+VL K Y+ D+WS G I L G P F G + D +K++ + W Sbjct: 215 IAPEVL--KKKYNEKCDVWSCGVIMYILLC-GYPPFGGQNDQDIIKKVEKGKYYFDFNDW 271 Query: 228 PSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFS 287 ++ ++L++ +L + +R +AEEAL + Sbjct: 272 K-------------------------NISDEAKELIKLMLTYDYNKRCTAEEALNSRWIK 306 Query: 288 DF 289 + Sbjct: 307 KY 308 >4RGJ-A nrPDB Length = 520 Score = 252 bits (645), Expect = 1e-67, Method: Composition-based stats. Identities = 75/291 (25%), Positives = 131/291 (45%), Gaps = 34/291 (11%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRV-RLDDDDEGVPSSALREICLLKELKH 60 ++Y+ ++ +G+G++G V ++++ T A+K + + + S LRE+ LLK L H Sbjct: 60 EQYKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKESLLREVELLKMLDH 119 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 NI++L++ + LV + + Q+L G+ + H Sbjct: 120 INIMKLYEFFEDNNYYYLVSDVYTGGELFDEIISRKRFYEIDAARIIKQILSGITYMHKN 179 Query: 121 NVLHRDLKPQNLLI----NRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGA 176 NV+HRDLKP+N+L+ + +K+ DFGL+ F + ++ T +Y PDVL G Sbjct: 180 NVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHFEY-SKKMKDKIGTAYYIAPDVLHGT 238 Query: 177 KLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDY 236 Y D+WS G I L + P F G++ D LK++ T Q+ Sbjct: 239 --YDEKCDIWSCGVILYILLSGC-PPFNGSNEYDILKKVEAGKYTFDLPQFK-------- 287 Query: 237 KPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFS 287 K++ +DL++ +L RISA +AL+H + Sbjct: 288 -----------------KISDKAKDLIKKMLMYTSAVRISARDALEHEWIK 321 >3MN3-A nrPDB Length = 271 Score = 252 bits (644), Expect = 1e-67, Method: Composition-based stats. Identities = 70/289 (24%), Positives = 129/289 (44%), Gaps = 33/289 (11%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPS-SALREICLLKELKHKN 62 Y+ ++ +GEG++G V A + T + VALK + + REI L+ L+H + Sbjct: 6 YQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRHPH 65 Query: 63 IVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNV 122 I++L+DV+ S ++ +V E+ +L Y + + + F Q++ + +CH + Sbjct: 66 IIKLYDVIKSKDEIIMVIEYAGNELFDYI-VQRDKMSEQEARRFFQQIISAVEYCHRHKI 124 Query: 123 LHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTS 182 +HRDLKP+NLL++ + +K+ADFGL+ + Y P+V+ G Sbjct: 125 VHRDLKPENLLLDEHLNVKIADFGLSNIMT-DGNFLKTSCGSPNYAAPEVISGKLYAGPE 183 Query: 183 IDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMY 242 +D+WS G I + P D+ + +F+ + Sbjct: 184 VDVWSCGVILYVMLCRRLPF-----DDESIPVLFKNI----------------------- 215 Query: 243 PATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCP 291 + + + L+ L++ +L NP+ RIS E +Q +F P Sbjct: 216 --SNGVYTLPKFLSPGAAGLIKRMLIVNPLNRISIHEIMQDDWFKVDLP 262 >3H4J-B nrPDB Length = 336 Score = 252 bits (643), Expect = 2e-67, Method: Composition-based stats. Identities = 72/289 (24%), Positives = 135/289 (46%), Gaps = 33/289 (11%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRV-RLDDDDEGVPSSALREICLLKELKHKN 62 Y E +GEG++G V A + +T + VALK + R + REI LK L+H + Sbjct: 11 YIIRETLGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREISYLKLLRHPH 70 Query: 63 IVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNV 122 I++L+DV+ + + +V E+ +L Y + + + F Q++ + +CH + Sbjct: 71 IIKLYDVITTPTDIVMVIEYAGGELFDYIVE-KKRMTEDEGRRFFQQIICAIEYCHRHKI 129 Query: 123 LHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTS 182 +HRDLKP+NLL++ N +K+ADFGL+ + Y P+V+ G Sbjct: 130 VHRDLKPENLLLDDNLNVKIADFGLSNIMT-DGNFLKTSCGSPNYAAPEVINGKLYAGPE 188 Query: 183 IDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMY 242 +D+WS G + + P D+ + +F+ + + + +PD+ Sbjct: 189 VDVWSCGIVLYVMLVGRLPF-----DDEFIPNLFKKVNSC-------VYVMPDF------ 230 Query: 243 PATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCP 291 L+ + L++ ++ +P+QRI+ +E + P+F+ P Sbjct: 231 ------------LSPGAQSLIRRMIVADPMQRITIQEIRRDPWFNVNLP 267 >4LG4-A nrPDB Length = 299 Score = 252 bits (643), Expect = 2e-67, Method: Composition-based stats. Identities = 74/289 (25%), Positives = 135/289 (46%), Gaps = 33/289 (11%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 ++ LEK+GEG+YG+VFKA ++E+ ++VA+K+V ++ D ++EI ++++ + Sbjct: 13 FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESD----LQEIIKEISIMQQCDSPYV 68 Query: 64 VRLHDVLHSDKKLTLVFEFCD-QDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNV 122 V+ + + L +V E+C + N L + + + L LKGL + H Sbjct: 69 VKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRK 128 Query: 123 LHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTS 182 +HR++K N+L+N G KLADFG+A + + + T ++ P+V+ Y+ Sbjct: 129 IHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI-QEIGYNCV 187 Query: 183 IDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMY 242 D+WS G E+A P ++ IF + P P ++ ++ Sbjct: 188 ADIWSLGITSIEMAEGKPPY----ADIHPMRAIFMIPTNPP----------PTFRKPELW 233 Query: 243 PATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCP 291 + D ++ L NP QR +A + LQHP+ + P Sbjct: 234 -------------SDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKP 269 >3BHH-A nrPDB Length = 295 Score = 251 bits (642), Expect = 2e-67, Method: Composition-based stats. Identities = 76/290 (26%), Positives = 116/290 (40%), Gaps = 30/290 (10%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 +Y+ E IG+G + V + T A K + RE + + LKH Sbjct: 4 DEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHS 63 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN 121 NIVRLHD + + LVF+ + Q+L+ + CH Sbjct: 64 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMG 123 Query: 122 VLHRDLKPQNLLINRNGE---LKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL 178 V+HRDLKP+NLL+ + +KLADFGLA + + T Y P+VL + Sbjct: 124 VVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVL-RKEA 182 Query: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKP 238 Y +D+W+ G I L G P F D ++I +W ++T Sbjct: 183 YGKPVDIWACGVILYILLV-GYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVT------- 234 Query: 239 YPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288 ++L+ +L NP +RI+A EAL+HP+ Sbjct: 235 ------------------PEAKNLINQMLTINPAKRITAHEALKHPWVCQ 266 >5WAX-A nrPDB Length = 310 Score = 251 bits (641), Expect = 3e-67, Method: Composition-based stats. Identities = 76/292 (26%), Positives = 126/292 (43%), Gaps = 30/292 (10%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 +YE + IG G +G +NR ++VA+K + + E + + REI + L+H Sbjct: 11 DRYELVRDIGSGNFGVARLMRNRADGQLVAVKYI---ERGEKIDENVQREIINHRSLRHP 67 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN 121 NI+R +V+ + L +V E+ G + + F QL+ G+ +CHS Sbjct: 68 NIIRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHSMQ 127 Query: 122 VLHRDLKPQNLLINRNG--ELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLY 179 V HRDLK +N L++ + LK+ DFG +++ + + S V T Y P+VL + Sbjct: 128 VCHRDLKLENTLLDGSTAPRLKICDFGYSKSSVLHSQPKST-VGTPAYIAPEVLLKKEYD 186 Query: 180 STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPY 239 D+WS G + P ++ + K I R+LG +PDY Sbjct: 187 GKVADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRILGV--------QYSIPDYV-- 236 Query: 240 PMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCP 291 ++ +DL+ + NP RI+ E HP+F P Sbjct: 237 --------------HISPECQDLISRIFVANPATRITIPEIRNHPWFLKNLP 274 >4UZD-A nrPDB Length = 287 Score = 251 bits (641), Expect = 3e-67, Method: Composition-based stats. Identities = 81/288 (28%), Positives = 137/288 (47%), Gaps = 34/288 (11%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRV-RLDDDDEGVPSSALREICLLKELK 59 ++ +E +G+G +G V+ A+ +++ I+ALK + + + GV RE+ + L+ Sbjct: 7 LEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLR 66 Query: 60 HKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 H NI+RL+ H ++ L+ E+ D + +++ +L L +CHS Sbjct: 67 HPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHS 126 Query: 120 RNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLY 179 + V+HRD+KP+NLL+ GELK+ADFG + P + TL Y PP+++ G +++ Sbjct: 127 KRVIHRDIKPENLLLGSAGELKIADFGWS--VHAPSSRRTTLCGTLDYLPPEMIEG-RMH 183 Query: 180 STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPY 239 +D+WS G + E G+P F N + KRI R+ T + Sbjct: 184 DEKVDLWSLGVLCYEFLV-GKPPFEANTYQETYKRISRVEFTFPD--------------- 227 Query: 240 PMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFS 287 + RDL+ LLK NP QR E L+HP+ + Sbjct: 228 --------------FVTEGARDLISRLLKHNPSQRPMLREVLEHPWIT 261 >3PG1-A nrPDB Length = 362 Score = 251 bits (641), Expect = 3e-67, Method: Composition-based stats. Identities = 96/306 (31%), Positives = 144/306 (47%), Gaps = 20/306 (6%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDD---------EGVPSSALREICL 54 Y I G+YG V + E VA+KRV D + LREI L Sbjct: 24 YTVQRFISSGSYGAVCAGVDSE-GIPVAIKRVFNTVSDGRTVNILSDSFLCKRVLREIRL 82 Query: 55 LKELKHKNIVRLHDVLHSDKK-----LTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQ 109 L H NI+ L D+ ++ L LV E DL + + P+ ++ F++ Sbjct: 83 LNHFHHPNILGLRDIFVHFEEPAMHKLYLVTELMRTDLAQVIHDQRIVISPQHIQYFMYH 142 Query: 110 LLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRP 169 +L GL H V+HRDL P N+L+ N ++ + DF LAR + V WYR Sbjct: 143 ILLGLHVLHEAGVVHRDLHPGNILLADNNDITICDFNLAREDTADANK-THYVTHRWYRA 201 Query: 170 PDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQ--- 226 P+++ K ++ +DMWSAGC+ AE+ N + LF G+ +QL +I ++GTP E Sbjct: 202 PELVMQFKGFTKLVDMWSAGCVMAEMFNR-KALFRGSTFYNQLNKIVEVVGTPKIEDVVM 260 Query: 227 WPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286 + S + + + VVP + DL+ +L+ NP +RIS E+AL+HPYF Sbjct: 261 FSSPSARDYLRNSLSNVPARAWTAVVPTADPVALDLIAKMLEFNPQRRISTEQALRHPYF 320 Query: 287 SDFCPP 292 P Sbjct: 321 ESLFDP 326 >4FG9-A nrPDB Length = 320 Score = 250 bits (639), Expect = 5e-67, Method: Composition-based stats. Identities = 74/287 (25%), Positives = 130/287 (45%), Gaps = 32/287 (11%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 Y+ + +G G + V A+++ T ++VA+K + + EG S EI +L ++KH NI Sbjct: 20 YDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEAL-EGKEGSMENEIAVLHKIKHPNI 78 Query: 64 VRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVL 123 V L D+ S L L+ + G +FQ+L + + H ++ Sbjct: 79 VALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLGIV 138 Query: 124 HRDLKPQNLL---INRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYS 180 HRDLKP+NLL ++ + ++ ++DFGL++ P S T Y P+VL K YS Sbjct: 139 HRDLKPENLLYYSLDEDSKIMISDFGLSK-MEDPGSVLSTACGTPGYVAPEVL-AQKPYS 196 Query: 181 TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYP 240 ++D WS G I L P + ND ++I + W Sbjct: 197 KAVDCWSIGVIAYILLCGYPPFYDENDAK-LFEQILKAEYEFDSPYWD------------ 243 Query: 241 MYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFS 287 ++ + +D +++L++ +P +R + E+ALQHP+ + Sbjct: 244 -------------DISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIA 277 >3KK8-A nrPDB Length = 284 Score = 250 bits (639), Expect = 5e-67, Method: Composition-based stats. Identities = 72/290 (24%), Positives = 120/290 (41%), Gaps = 31/290 (10%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 Y+ E++G+G + V + ++ T A K + RE + ++L+H Sbjct: 6 DNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQHP 65 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN 121 NIVRLHD + + LVF+ + Q+L+ + +CHS Sbjct: 66 NIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCHSNG 125 Query: 122 VLHRDLKPQNLLINRNGE---LKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL 178 ++HR+LKP+NLL+ + +KLADFGLA + T Y P+VL Sbjct: 126 IVHRNLKPENLLLASKAKGAAVKLADFGLAIEVN-DSEAWHGFAGTPGYLSPEVL-KKDP 183 Query: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKP 238 YS +D+W+ G I L G P F D +I +W ++T Sbjct: 184 YSKPVDIWACGVILYILLV-GYPPFWDEDQHRLYAQIKAGAYDYPSPEWDTVT------- 235 Query: 239 YPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288 + L+ ++L NP +RI+A++AL+ P+ + Sbjct: 236 ------------------PEAKSLIDSMLTVNPKKRITADQALKVPWICN 267 >4CZT-A nrPDB Length = 464 Score = 250 bits (639), Expect = 5e-67, Method: Composition-based stats. Identities = 82/291 (28%), Positives = 130/291 (44%), Gaps = 33/291 (11%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDD-DDEGVPSSALREICLLKELKHK 61 KYE +GEGT+ V A+N E + VA+K + + + + REI +K +KH Sbjct: 12 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHP 71 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN 121 N++R+ +V+ S K+ V EF S NG L + + + QL+ + +CHSR Sbjct: 72 NVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRG 131 Query: 122 VLHRDLKPQNLLINRNGELKLADFGLARAFGI--PVRCYSAEVVTLWYRPPDVLFGAKLY 179 V HRDLKP+NLL++ NG LK++DFGL+ T Y P+V+ Sbjct: 132 VYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYD 191 Query: 180 STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPY 239 D+WS G I L P F +++ K+IF+ T Sbjct: 192 GAKADLWSCGVILFVLMAGYLP-FEDSNLTSLYKKIFKAEFTCP---------------- 234 Query: 240 PMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFC 290 P +A+ + L++ +L NP RI+ E +++ +F Sbjct: 235 -------------PWFSASAKKLIKRILDPNPATRITFAEVIENEWFKKGY 272 >3D2K-A nrPDB Length = 272 Score = 250 bits (638), Expect = 6e-67, Method: Composition-based stats. Identities = 79/288 (27%), Positives = 137/288 (47%), Gaps = 34/288 (11%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRV-RLDDDDEGVPSSALREICLLKELK 59 ++ ++ +G+G +G V+ A+ R++ I+ALK + + + GV RE+ + L+ Sbjct: 11 LEDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVEHQLRREVEIQSHLR 70 Query: 60 HKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 H NI+RL+ H ++ L+ E+ D + +++ +L L +CHS Sbjct: 71 HPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSRFDEQRTATYITELANALSYCHS 130 Query: 120 RNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLY 179 + V+HRD+KP+NLL+ NGELK+ADFG + P + TL Y PP+++ G +++ Sbjct: 131 KRVIHRDIKPENLLLGSNGELKIADFGWS--VHAPSSRRTTLCGTLDYLPPEMIEG-RMH 187 Query: 180 STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPY 239 +D+WS G + E G P F + + +RI R+ T + Sbjct: 188 DEKVDLWSLGVLCYEFLV-GMPPFEAHTYQETYRRISRVEFTFPD--------------- 231 Query: 240 PMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFS 287 + RDL+ LLK N QR++ E L+HP+ Sbjct: 232 --------------FVTEGARDLISRLLKHNASQRLTLAEVLEHPWIK 265 >6AO5-A nrPDB Length = 362 Score = 250 bits (638), Expect = 7e-67, Method: Composition-based stats. Identities = 74/289 (25%), Positives = 135/289 (46%), Gaps = 33/289 (11%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 ++ LEK+GEG+YG+VFKA ++E+ ++VA+K+V ++ D ++EI ++++ + Sbjct: 12 FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESD----LQEIIKEISIMQQCDSPYV 67 Query: 64 VRLHDVLHSDKKLTLVFEFCD-QDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNV 122 V+ + + L +V E+C + N L + + + L LKGL + H Sbjct: 68 VKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRK 127 Query: 123 LHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTS 182 +HR++K N+L+N G KLADFG+A + + + T ++ P+V+ Y+ Sbjct: 128 IHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI-QEIGYNCV 186 Query: 183 IDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMY 242 D+WS G E+A P ++ IF + P P ++ ++ Sbjct: 187 ADIWSLGITSIEMAEGKPPY----ADIHPMRAIFMIPTNPP----------PTFRKPELW 232 Query: 243 PATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCP 291 + D ++ L NP QR +A + LQHP+ + P Sbjct: 233 -------------SDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKP 268 >5XZW-A nrPDB Length = 471 Score = 250 bits (638), Expect = 7e-67, Method: Composition-based stats. Identities = 81/302 (26%), Positives = 130/302 (43%), Gaps = 43/302 (14%) Query: 2 QKYEKL-EKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 + + + E +G+G + TV KA R T + A+K + G RE+ +L++L H Sbjct: 195 KDFSIIDEVVGQGAFATVKKAIERTTGKTFAVKIISKRKVI-GNMDGVTRELEVLQKLNH 253 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 IVRL + +V EF F + +G + + + Q+L + + HS Sbjct: 254 PRIVRLKGFYEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSM 313 Query: 121 NVLHRDLKPQNLLINRNGE--LKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL 178 + HRDLKP N+LI ++ +K+ DFGLA+ G TL Y P+V+ G Sbjct: 314 GISHRDLKPDNILIEQDDPVLVKITDFGLAKVQGN-GSFMKTFCGTLAYVAPEVIRGKDT 372 Query: 179 ------------YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQ 226 YS+ +DMWS GC+ + P F G+ D K+I R G+ E Sbjct: 373 SVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLP-FSGSTQDQLYKQIGR--GSYHEGP 429 Query: 227 WPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286 +++ RD + +LL+ +P R +A +AL HP+ Sbjct: 430 LKDF-----------------------RISEEARDFIDSLLQVDPNNRSTAAKALNHPWI 466 Query: 287 SD 288 D Sbjct: 467 VD 468 >3SOA-A nrPDB Length = 444 Score = 249 bits (636), Expect = 1e-66, Method: Composition-based stats. Identities = 73/289 (25%), Positives = 117/289 (40%), Gaps = 30/289 (10%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 ++Y+ E++G+G + V + + A + RE + + LKH Sbjct: 11 EEYQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDHQKLEREARICRLLKHP 70 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN 121 NIVRLHD + + L+F+ + Q+L+ + CH Sbjct: 71 NIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMG 130 Query: 122 VLHRDLKPQNLLIN---RNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL 178 V+HR+LKP+NLL+ + +KLADFGLA + + T Y P+VL Sbjct: 131 VVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVL-RKDP 189 Query: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKP 238 Y +D+W+ G I L G P F D ++I +W ++T Sbjct: 190 YGKPVDLWACGVILYILLV-GYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVT------- 241 Query: 239 YPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFS 287 +DL+ +L NP +RI+A EAL+HP+ S Sbjct: 242 ------------------PEAKDLINKMLTINPSKRITAAEALKHPWIS 272 >2JC6-A nrPDB Length = 334 Score = 248 bits (635), Expect = 2e-66, Method: Composition-based stats. Identities = 72/287 (25%), Positives = 126/287 (43%), Gaps = 32/287 (11%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 +E E +G G + V A+ + T ++ A+K + G SS EI +L+++KH+NI Sbjct: 24 FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALK-GKESSIENEIAVLRKIKHENI 82 Query: 64 VRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVL 123 V L D+ S L LV + G + + + Q+L + + H ++ Sbjct: 83 VALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIV 142 Query: 124 HRDLKPQNLLI---NRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYS 180 HRDLKP+NLL + ++ ++DFGL++ S T Y P+VL K YS Sbjct: 143 HRDLKPENLLYYSQDEESKIMISDFGLSK-MEGKGDVMSTACGTPGYVAPEVL-AQKPYS 200 Query: 181 TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYP 240 ++D WS G I L P + ND ++I + W Sbjct: 201 KAVDCWSIGVIAYILLCGYPPFYDENDSK-LFEQILKAEYEFDSPYWD------------ 247 Query: 241 MYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFS 287 ++ + +D ++NL++ +P +R + E+A +HP+ + Sbjct: 248 -------------DISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIA 281 >4CFF-A nrPDB Length = 571 Score = 248 bits (634), Expect = 2e-66, Method: Composition-based stats. Identities = 67/292 (22%), Positives = 126/292 (43%), Gaps = 32/292 (10%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDE-GVPSSALREICLLKELK 59 + Y + +G GT+G V +++ T VA+K + V REI LK + Sbjct: 32 IGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR 91 Query: 60 HKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 H +I++L+ V+ + +V E+ + +G ++ + Q+L + +CH Sbjct: 92 HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHR 151 Query: 120 RNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLY 179 V+HRDLKP+N+L++ + K+ADFGL+ + Y P+V+ G Sbjct: 152 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS-DGEFLRTSCGSPNYAAPEVISGRLYA 210 Query: 180 STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPY 239 +D+WS G I L P D+ + +F+ + + +P+Y Sbjct: 211 GPEVDIWSCGVILYALLCGTLPF-----DDEHVPTLFKKI-------RGGVFYIPEY--- 255 Query: 240 PMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCP 291 LN + LL ++L+ +P++R + ++ +H +F P Sbjct: 256 ---------------LNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLP 292 >4CFH-A nrPDB Length = 493 Score = 248 bits (634), Expect = 2e-66, Method: Composition-based stats. Identities = 73/292 (25%), Positives = 128/292 (43%), Gaps = 32/292 (10%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDE-GVPSSALREICLLKELK 59 + Y + +G GT+G V K+ T VA+K + V REI LK + Sbjct: 32 IGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFR 91 Query: 60 HKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 H +I++L+ V+ + + +V E+ + NG LD + + Q+L G+ +CH Sbjct: 92 HPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHR 151 Query: 120 RNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLY 179 V+HRDLKP+N+L++ + K+ADFGL+ + Y P+V+ G Sbjct: 152 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS-DGEFLRTSCGSPNYAAPEVISGRLYA 210 Query: 180 STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPY 239 +D+WS+G I L P DD + +F+ + + P Y Sbjct: 211 GPEVDIWSSGVILYALLCGTLPF-----DDDHVPTLFKKI-------CDGIFYTPQY--- 255 Query: 240 PMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCP 291 LN + LL+++L+ +P++R + ++ +H +F P Sbjct: 256 ---------------LNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLP 292 >5KCV-A nrPDB Length = 460 Score = 248 bits (634), Expect = 2e-66, Method: Composition-based stats. Identities = 65/294 (22%), Positives = 125/294 (42%), Gaps = 38/294 (12%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDD-DEGVPSSALREICLLKELK 59 M ++E L+ +G+GT+G V K + T A+K ++ + + + L E +L+ + Sbjct: 161 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSR 220 Query: 60 HKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 H + L + +L V E+ + + S + + + +++ L + HS Sbjct: 221 HPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHS 280 Query: 120 -RNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL 178 +NV++RDLK +NL+++++G +K+ DFGL + T Y P+VL Sbjct: 281 EKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDND- 339 Query: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKP 238 Y ++D W G + E+ P + + +++F L+ Sbjct: 340 YGRAVDWWGLGVVMYEMMCGRLPFY-----NQDHEKLFELI------------------- 375 Query: 239 YPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRIS-----AEEALQHPYFS 287 + L + LL LLK +P QR+ A+E +QH +F+ Sbjct: 376 ------LMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFA 423 >2I6L-A nrPDB Length = 320 Score = 248 bits (634), Expect = 2e-66, Method: Composition-based stats. Identities = 107/309 (34%), Positives = 157/309 (50%), Gaps = 24/309 (7%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62 +Y L+ +G G G VF A + + + VA+K++ L D ALREI +++ L H N Sbjct: 12 RYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVL--TDPQSVKHALREIKIIRRLDHDN 69 Query: 63 IVRLH--------------DVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLF 108 IV++ L + +V E+ + DL + G L E + F++ Sbjct: 70 IVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLE--QGPLLEEHARLFMY 127 Query: 109 QLLKGLGFCHSRNVLHRDLKPQNLLIN-RNGELKLADFGLARAFGIPVRCYSAE---VVT 164 QLL+GL + HS NVLHRDLKP NL IN + LK+ DFGLAR +VT Sbjct: 128 QLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVT 187 Query: 165 LWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTE 224 WYR P +L Y+ +IDMW+AGCIFAE+ G+ LF G +Q++ I + E Sbjct: 188 KWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLT-GKTLFAGAHELEQMQLILESIPVVHE 246 Query: 225 EQWPSMTK-LPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQH 283 E + +P Y M L ++P ++ D L+ +L +P+ R++AEEAL H Sbjct: 247 EDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREAVDFLEQILTFSPMDRLTAEEALSH 306 Query: 284 PYFSDFCPP 292 PY S + P Sbjct: 307 PYMSIYSFP 315 >5EZV-A nrPDB Length = 560 Score = 248 bits (633), Expect = 2e-66, Method: Composition-based stats. Identities = 67/292 (22%), Positives = 126/292 (43%), Gaps = 32/292 (10%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDE-GVPSSALREICLLKELK 59 + Y + +G GT+G V +++ T VA+K + V REI LK + Sbjct: 27 IGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR 86 Query: 60 HKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 H +I++L+ V+ + +V E+ + +G ++ + Q+L + +CH Sbjct: 87 HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHR 146 Query: 120 RNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLY 179 V+HRDLKP+N+L++ + K+ADFGL+ + Y P+V+ G Sbjct: 147 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS-DGEFLRTSCGSPNYAAPEVISGRLYA 205 Query: 180 STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPY 239 +D+WS G I L P D+ + +F+ + + +P+Y Sbjct: 206 GPEVDIWSCGVILYALLCGTLPF-----DDEHVPTLFKKI-------RGGVFYIPEY--- 250 Query: 240 PMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCP 291 LN + LL ++L+ +P++R + ++ +H +F P Sbjct: 251 ---------------LNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLP 287 >4RED-A nrPDB Length = 351 Score = 248 bits (633), Expect = 3e-66, Method: Composition-based stats. Identities = 74/292 (25%), Positives = 128/292 (43%), Gaps = 32/292 (10%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDE-GVPSSALREICLLKELK 59 + Y + +G GT+G V K+ T VA+K + V REI LK + Sbjct: 13 IGHYILGDTLGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLDVVGKIRREIQNLKLFR 72 Query: 60 HKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 H +I++L+ V+ + + +V E+ + NG LD + + Q+L G+ +CH Sbjct: 73 HPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHR 132 Query: 120 RNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLY 179 V+HRDLKP+N+L++ + K+ADFGL+ + Y P+V+ G Sbjct: 133 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS-DGEFLRTSCGSPNYAAPEVISGRLYA 191 Query: 180 STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPY 239 +D+WS+G I L P DD + +F+ + + P Y Sbjct: 192 GPEVDIWSSGVILYALLCGTLPF-----DDDHVPTLFKKI-------CDGIFYTPQY--- 236 Query: 240 PMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCP 291 LN + LL+++L+ +P++R S ++ +H +F P Sbjct: 237 ---------------LNPSVISLLKHMLQVDPMKRASIKDIREHEWFKQDLP 273 >4D28-A nrPDB Length = 446 Score = 247 bits (630), Expect = 5e-66, Method: Composition-based stats. Identities = 84/291 (28%), Positives = 130/291 (44%), Gaps = 31/291 (10%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRV-RLDDDDEGVPSSALREICLLKELKHK 61 KYE IGEGT+ V A+N +T + VA+K + + + REI ++K ++H Sbjct: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN 121 NIVRL++VL S K+ +V EF G L + + + QL+ + CHS+ Sbjct: 70 NIVRLYEVLASKSKIYIVLEFVTGGELFDRIVHKGRLKEDESRKYFQQLVDAVAHCHSKG 129 Query: 122 VLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYST 181 V HRDLKP+NLL++ NG LK++DFGL+ V + T Y P+VL G + Sbjct: 130 VYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLNDTCGTPNYVAPEVLSGQGYDGS 189 Query: 182 SIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPM 241 + D+WS G I + P F D+ ++I Sbjct: 190 AADIWSCGVILFVILAGYLP-FSETDLPGLYRKI-------------------------- 222 Query: 242 YPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 292 + + P +A + L+ +L NP RI + + P+F P Sbjct: 223 ---NAAEFDCPPWFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRKNYVP 270 >3MV5-A nrPDB Length = 342 Score = 246 bits (628), Expect = 1e-65, Method: Composition-based stats. Identities = 65/294 (22%), Positives = 125/294 (42%), Gaps = 38/294 (12%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDD-DEGVPSSALREICLLKELK 59 M ++E L+ +G+GT+G V K + T A+K ++ + + + L E +L+ + Sbjct: 9 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSR 68 Query: 60 HKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 H + L + +L V E+ + + S + + + +++ L + HS Sbjct: 69 HPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHS 128 Query: 120 -RNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL 178 +NV++RDLK +NL+++++G +K+ DFGL + T Y P+VL Sbjct: 129 EKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDND- 187 Query: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKP 238 Y ++D W G + E+ P + + +++F L+ Sbjct: 188 YGRAVDWWGLGVVMYEMMCGRLPFY-----NQDHEKLFELI------------------- 223 Query: 239 YPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRIS-----AEEALQHPYFS 287 + L + LL LLK +P QR+ A+E +QH +F+ Sbjct: 224 ------LMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFA 271 >2JDO-A nrPDB Length = 342 Score = 245 bits (627), Expect = 1e-65, Method: Composition-based stats. Identities = 63/292 (21%), Positives = 124/292 (42%), Gaps = 37/292 (12%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLD-DDDEGVPSSALREICLLKELK 59 M ++ L+ +G+GT+G V + + T A+K +R + + + + E +L+ + Sbjct: 9 MNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTR 68 Query: 60 HKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 H + L + +L V E+ + + S E + + +++ L + HS Sbjct: 69 HPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHS 128 Query: 120 RNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLY 179 R+V++RD+K +NL+++++G +K+ DFGL + T Y P+VL Y Sbjct: 129 RDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDND-Y 187 Query: 180 STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPY 239 ++D W G + E+ P + + +R+F L+ Sbjct: 188 GRAVDWWGLGVVMYEMMCGRLPFY-----NQDHERLFELI-------------------- 222 Query: 240 PMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRIS-----AEEALQHPYF 286 + L+ + LL LLK +P QR+ A+E ++H +F Sbjct: 223 -----LMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFF 269 >5J5T-A nrPDB Length = 370 Score = 245 bits (626), Expect = 2e-65, Method: Composition-based stats. Identities = 78/289 (26%), Positives = 133/289 (46%), Gaps = 29/289 (10%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 + +E +++IG GTYG V+KA+N T E+ A+K ++L+ ++ +EI ++K+ KH Sbjct: 4 EDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAV--VQQEIIMMKDCKHP 61 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN 121 NIV KL + EFC + G L + + L+GL + HS+ Sbjct: 62 NIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSKG 121 Query: 122 VLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDV--LFGAKLY 179 +HRD+K N+L+ NG +KLADFG++ + A + T ++ P+V + Y Sbjct: 122 KMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKAFIGTPYWMAPEVAAVERKGGY 181 Query: 180 STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPY 239 + D+W+ G ELA P+F + + L T + Q P + Sbjct: 182 NQLCDLWAVGITAIELAELQPPMFDLHPMRALF------LMTKSNFQPPKLKDKM----- 230 Query: 240 PMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288 K + + ++ L NP +R +AE+ LQHP+ + Sbjct: 231 --------------KWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQ 265 >6FD3-A nrPDB Length = 300 Score = 244 bits (623), Expect = 4e-65, Method: Composition-based stats. Identities = 77/290 (26%), Positives = 126/290 (43%), Gaps = 31/290 (10%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 +KY + EKIG+G GTV+ A + T + VA+K++ L + + EI +++E K+ Sbjct: 22 KKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKK--ELIINEILVMRENKNP 79 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN 121 NIV D +L +V E+ + +D + + + L+ L F HS Sbjct: 80 NIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTET-CMDEGQIAAVCRECLQALDFLHSNQ 138 Query: 122 VLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYST 181 V+HRD+K N+L+ +G +KL DFG S V T ++ P+V+ K Y Sbjct: 139 VIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVV-TRKAYGP 197 Query: 182 SIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPM 241 +D+WS G + E+ P + + P Y + Sbjct: 198 KVDIWSLGIMAIEMVEGEPPY---------------------------LNENPLRALYLI 230 Query: 242 YPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCP 291 T + +L+A RD L L+ + +R SA+E LQHP+ P Sbjct: 231 ATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLDKP 280 >4FIE-A nrPDB Length = 423 Score = 243 bits (622), Expect = 5e-65, Method: Composition-based stats. Identities = 67/284 (23%), Positives = 130/284 (45%), Gaps = 31/284 (10%) Query: 9 KIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHD 68 KIGEG+ G V A R + ++VA+K++ L E+ ++++ +H+N+V +++ Sbjct: 158 KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRR--ELLFNEVVIMRDYQHENVVEMYN 215 Query: 69 VLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLK 128 +L +V EF + + + ++ E + + +L+ L H++ V+HRD+K Sbjct: 216 SYLVGDELWVVMEFLEGGALTDIVT-HTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIK 274 Query: 129 PQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSA 188 ++L+ +G +KL+DFG V + V T ++ P+++ Y +D+WS Sbjct: 275 SDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELI-SRLPYGPEVDIWSL 333 Query: 189 GCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSL 248 G + E+ + P F E +M + D P Sbjct: 334 GIMVIEMVDGEPPYF-------------------NEPPLKAMKMIRDNLP--------PR 366 Query: 249 VNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 292 + + K++ + + L LL +P QR +A E L+HP+ + PP Sbjct: 367 LKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPP 410 >5Y86-A nrPDB Length = 588 Score = 243 bits (620), Expect = 7e-65, Method: Composition-based stats. Identities = 89/328 (27%), Positives = 148/328 (45%), Gaps = 47/328 (14%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK- 61 +YE L+ IG+G++G V + + + + VALK VR +++ A EI +L+ LK + Sbjct: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVR---NEKRFHRQAAEEIRILEHLKKQD 264 Query: 62 -----NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCN-GDLDPEIVKSFLFQLLKGLG 115 N++ + + + + FE DL + ++V+ F +L+ L Sbjct: 265 KTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLD 324 Query: 116 FCHSRNVLHRDLKPQNLLINRNGE--LKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVL 173 H ++H DLKP+N+L+ +G K+ DFG + + + + +YR P+++ Sbjct: 325 ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC---FEYQKLYTYIQSRFYRAPEII 381 Query: 174 FGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTE---EQWPSM 230 G++ YST ID+WS GCI AEL G+PLFPG D DQL + LLG P EQ Sbjct: 382 LGSR-YSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRA 439 Query: 231 TKLPDYKPYPMY--------------------------PATTSLVNVVPKLNA-TGRDLL 263 + K P Y P + + + + L Sbjct: 440 KYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFL 499 Query: 264 QNLLKCNPVQRISAEEALQHPYFSDFCP 291 + L +P R++ +AL+HP+ S P Sbjct: 500 KRCLHWDPSARLTPAQALRHPWISKSVP 527 >3TAC-A nrPDB Length = 361 Score = 243 bits (620), Expect = 9e-65, Method: Composition-based stats. Identities = 75/295 (25%), Positives = 122/295 (41%), Gaps = 38/295 (12%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEG---VPSSALREICLLKELKH 60 YE E IG+G + V + NRET + A+K V + RE + LKH Sbjct: 28 YELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKH 87 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCDQ-DLKKYFDSC---NGDLDPEIVKSFLFQLLKGLGF 116 +IV L + SD L +VFEF D DL + ++ Q+L+ L + Sbjct: 88 PHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRY 147 Query: 117 CHSRNVLHRDLKPQNLLINR---NGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVL 173 CH N++HRD+KP +L+ + +KL FG+A G V T + P+V+ Sbjct: 148 CHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFMAPEVV 207 Query: 174 FGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKL 233 + Y +D+W G I L + P + + + I + QW Sbjct: 208 -KREPYGKPVDVWGCGVILFILLSGCLPFYGTKER--LFEGIIKGKYKMNPRQW------ 258 Query: 234 PDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288 ++ + +DL++ +L +P +RI+ EAL HP+ + Sbjct: 259 -------------------SHISESAKDLVRRMLMLDPAERITVYEALNHPWLKE 294 >3ZUT-A nrPDB Length = 362 Score = 242 bits (618), Expect = 1e-64, Method: Composition-based stats. Identities = 72/292 (24%), Positives = 126/292 (43%), Gaps = 30/292 (10%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 +YE ++ IG G +G ++++++E+VA+K + + E + + REI + L+H Sbjct: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYI---ERGEKIDENVKREIINHRSLRHP 75 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN 121 NIVR +V+ + L +V E+ G + + F QL+ G+ +CH+ Sbjct: 76 NIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQ 135 Query: 122 VLHRDLKPQNLLINRN--GELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLY 179 V HRDLK +N L++ + LK+ FG +++ + + S V T Y P+VL + Sbjct: 136 VCHRDLKLENTLLDGSPAPRLKICAFGYSKSSVLHSQPKST-VGTPAYIAPEVLLKKEYD 194 Query: 180 STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPY 239 D+WS G + P + + K I R+L +PDY Sbjct: 195 GKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRIL--------NVQYAIPDYV-- 244 Query: 240 PMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCP 291 ++ R L+ + +P +RIS E H +F P Sbjct: 245 --------------HISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNLP 282 >2YCR-A nrPDB Length = 323 Score = 242 bits (618), Expect = 1e-64, Method: Composition-based stats. Identities = 70/298 (23%), Positives = 118/298 (39%), Gaps = 38/298 (12%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSA------LREICLL 55 +Y + +G G G V A R+T + VA+K + G A EI +L Sbjct: 10 DEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEIL 69 Query: 56 KELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLG 115 K+L H I+++ + ++ +V E + N L K + +Q+L + Sbjct: 70 KKLNHPCIIKIKNFFDAEDY-YIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQ 128 Query: 116 FCHSRNVLHRDLKPQNLLIN---RNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDV 172 + H ++HRDLKP+N+L++ + +K+ DFG ++ G T Y P+V Sbjct: 129 YLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILG-ETSLMRTLCGTPTYLAPEV 187 Query: 173 L--FGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSM 230 L G Y+ ++D WS G I + P +I E W Sbjct: 188 LVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWA-- 245 Query: 231 TKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288 +++ DL++ LL +P R + EEAL+HP+ D Sbjct: 246 -----------------------EVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQD 280 >4JDH-A nrPDB Length = 346 Score = 241 bits (616), Expect = 3e-64, Method: Composition-based stats. Identities = 67/284 (23%), Positives = 130/284 (45%), Gaps = 31/284 (10%) Query: 9 KIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHD 68 KIGEG+ G V A R + ++VA+K++ L E+ ++++ +H+N+V +++ Sbjct: 81 KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRR--ELLFNEVVIMRDYQHENVVEMYN 138 Query: 69 VLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLK 128 +L +V EF + + + ++ E + + +L+ L H++ V+HRD+K Sbjct: 139 SYLVGDELWVVMEFLEGGALTDIVT-HTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIK 197 Query: 129 PQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSA 188 ++L+ +G +KL+DFG V + V T ++ P+++ Y +D+WS Sbjct: 198 SDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELI-SRLPYGPEVDIWSL 256 Query: 189 GCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSL 248 G + E+ + P F E +M + D P Sbjct: 257 GIMVIEMVDGEPPYF-------------------NEPPLKAMKMIRDNLP--------PR 289 Query: 249 VNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 292 + + K++ + + L LL +P QR +A E L+HP+ + PP Sbjct: 290 LKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPP 333 >2UV2-A nrPDB Length = 325 Score = 241 bits (616), Expect = 3e-64, Method: Composition-based stats. Identities = 67/289 (23%), Positives = 124/289 (42%), Gaps = 34/289 (11%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 +E + ++G+G +G V+KA+N+ET + A K + ++E + EI +L H NI Sbjct: 39 WEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEE--LEDYMVEIDILASCDHPNI 96 Query: 64 VRLHDVLHSDKKLTLVFEFCDQDLKK-YFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNV 122 V+L D + + L ++ EFC L ++ Q L L + H + Sbjct: 97 VKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHDNKI 156 Query: 123 LHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLF----GAKL 178 +HRDLK N+L +G++KLADFG++ ++ + + T ++ P+V+ + Sbjct: 157 IHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRP 216 Query: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKP 238 Y D+WS G E+A P + L +I + Sbjct: 217 YDYKADVWSLGITLIEMAEIE-PPHHELNPMRVLLKIAK--------------------- 254 Query: 239 YPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFS 287 + + + ++ +D L+ L+ N R + + LQHP+ + Sbjct: 255 -----SEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVT 298 >4L42-A nrPDB Length = 346 Score = 241 bits (616), Expect = 3e-64, Method: Composition-based stats. Identities = 73/294 (24%), Positives = 121/294 (41%), Gaps = 41/294 (13%) Query: 4 YEKLEKIGEGTYGTVF---KAKNRETHEIVALKRVRLDD--DDEGVPSSALREICLLKEL 58 +E L +G+G YG VF K T +I A+K ++ + + E +L+E+ Sbjct: 20 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEV 79 Query: 59 KHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCH 118 KH IV L + KL L+ E+ G + +L ++ LG H Sbjct: 80 KHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLH 139 Query: 119 SRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL 178 + +++RDLKP+N+++N G +KL DFGL + T+ Y P++L Sbjct: 140 QKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILM-RSG 198 Query: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKP 238 ++ ++D WS G + ++ P F G + + +I + Sbjct: 199 HNRAVDWWSLGALMYDMLTGA-PPFTGENRKKTIDKILKC-------------------- 237 Query: 239 YPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRIS-----AEEALQHPYFS 287 +N+ P L RDLL+ LLK N R+ A E HP+F Sbjct: 238 ---------KLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFR 282 >2YZA-A nrPDB Length = 276 Score = 241 bits (615), Expect = 3e-64, Method: Composition-based stats. Identities = 67/292 (22%), Positives = 126/292 (43%), Gaps = 32/292 (10%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDE-GVPSSALREICLLKELK 59 + Y + +G GT+G V +++ T VA+K + V REI LK + Sbjct: 10 IGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR 69 Query: 60 HKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 H +I++L+ V+ + +V E+ + +G ++ + Q+L + +CH Sbjct: 70 HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHR 129 Query: 120 RNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLY 179 V+HRDLKP+N+L++ + K+ADFGL+ + Y P+V+ G Sbjct: 130 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS-DGEFLRDSCGSPNYAAPEVISGRLYA 188 Query: 180 STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPY 239 +D+WS G I L P D+ + +F+ + + +P+Y Sbjct: 189 GPEVDIWSCGVILYALLCGTLPF-----DDEHVPTLFKKI-------RGGVFYIPEY--- 233 Query: 240 PMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCP 291 LN + LL ++L+ +P++R + ++ +H +F P Sbjct: 234 ---------------LNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLP 270 >4XBR-A nrPDB Length = 366 Score = 241 bits (615), Expect = 3e-64, Method: Composition-based stats. Identities = 67/284 (23%), Positives = 130/284 (45%), Gaps = 31/284 (10%) Query: 9 KIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHD 68 KIGEG+ G V A R + ++VA+K++ L E+ ++++ +H+N+V +++ Sbjct: 101 KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRR--ELLFNEVVIMRDYQHENVVEMYN 158 Query: 69 VLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLK 128 +L +V EF + + + ++ E + + +L+ L H++ V+HRD+K Sbjct: 159 SYLVGDELWVVMEFLEGGALTDIVT-HTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIK 217 Query: 129 PQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSA 188 ++L+ +G +KL+DFG V + V T ++ P+++ Y +D+WS Sbjct: 218 SDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELI-SRLPYGPEVDIWSL 276 Query: 189 GCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSL 248 G + E+ + P F E +M + D P Sbjct: 277 GIMVIEMVDGEPPYF-------------------NEPPLKAMKMIRDNLP--------PR 309 Query: 249 VNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 292 + + K++ + + L LL +P QR +A E L+HP+ + PP Sbjct: 310 LKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPP 353 >2W4O-A nrPDB Length = 349 Score = 241 bits (615), Expect = 3e-64, Method: Composition-based stats. Identities = 70/287 (24%), Positives = 120/287 (41%), Gaps = 34/287 (11%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 +E ++G G V++ K + T + ALK ++ D + V EI +L L H NI Sbjct: 55 FEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKIVR----TEIGVLLRLSHPNI 110 Query: 64 VRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVL 123 ++L ++ + +++LV E G + Q+L+ + + H ++ Sbjct: 111 IKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIV 170 Query: 124 HRDLKPQNLLINR---NGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYS 180 HRDLKP+NLL + LK+ADFGL++ V T Y P++L G Y Sbjct: 171 HRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQV-LMKTVCGTPGYCAPEILRGC-AYG 228 Query: 181 TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYP 240 +DMWS G I L P + +RI W Sbjct: 229 PEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWD------------ 276 Query: 241 MYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFS 287 +++ +DL++ L+ +P +R++ +ALQHP+ + Sbjct: 277 -------------EVSLNAKDLVRKLIVLDPKKRLTTFQALQHPWVT 310 >2Q0N-A nrPDB Length = 301 Score = 241 bits (615), Expect = 3e-64, Method: Composition-based stats. Identities = 67/284 (23%), Positives = 130/284 (45%), Gaps = 31/284 (10%) Query: 9 KIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHD 68 KIGEG+ G V A R + ++VA+K++ L E+ ++++ +H+N+V +++ Sbjct: 36 KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRR--ELLFNEVVIMRDYQHENVVEMYN 93 Query: 69 VLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLK 128 +L +V EF + + + ++ E + + +L+ L H++ V+HRD+K Sbjct: 94 SYLVGDELWVVMEFLEGGALTDIVT-HTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIK 152 Query: 129 PQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSA 188 ++L+ +G +KL+DFG V + V T ++ P+++ Y +D+WS Sbjct: 153 SDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELI-SRLPYGPEVDIWSL 211 Query: 189 GCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSL 248 G + E+ + P F E +M + D P Sbjct: 212 GIMVIEMVDGEPPYF-------------------NEPPLKAMKMIRDNLP--------PR 244 Query: 249 VNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 292 + + K++ + + L LL +P QR +A E L+HP+ + PP Sbjct: 245 LKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPP 288 >4JXF-A nrPDB Length = 266 Score = 241 bits (615), Expect = 3e-64, Method: Composition-based stats. Identities = 72/289 (24%), Positives = 130/289 (44%), Gaps = 33/289 (11%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRV-RLDDDDEGVPSSALREICLLKELK 59 ++ ++ +G+G++ V++A++ T VA+K + + G+ E+ + +LK Sbjct: 6 IEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLK 65 Query: 60 HKNIVRLHDVLHSDKKLTLVFEFC-DQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCH 118 H +I+ L++ + LV E C + ++ +Y + + F+ Q++ G+ + H Sbjct: 66 HPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLH 125 Query: 119 SRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL 178 S +LHRDL NLL+ RN +K+ADFGLA +P + T Y P+ + Sbjct: 126 SHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPE-IATRSA 184 Query: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKP 238 + D+WS GC+F L GRP F + V + L ++ Sbjct: 185 HGLESDVWSLGCMFYTLLI-GRPPFDTDTVKNTLNKVV---------------------- 221 Query: 239 YPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFS 287 + + L+ +DL+ LL+ NP R+S L HP+ S Sbjct: 222 -------LADYEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFMS 263 >2Y7J-A nrPDB Length = 365 Score = 241 bits (615), Expect = 3e-64, Method: Composition-based stats. Identities = 74/298 (24%), Positives = 131/298 (43%), Gaps = 39/298 (13%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDD------EGVPSSALREICLL 55 QKY+ + IG G V + +R T A+K + + + E V + RE +L Sbjct: 94 QKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHIL 153 Query: 56 KEL-KHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGL 114 +++ H +I+ L D S + LVF+ + + + L + +S + LL+ + Sbjct: 154 RQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLEAV 213 Query: 115 GFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVL- 173 F H+ N++HRDLKP+N+L++ N +++L+DFG + P T Y P++L Sbjct: 214 SFLHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHL-EPGEKLRELCGTPGYLAPEILK 272 Query: 174 ----FGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPS 229 Y +D+W+ G I L P + + L+ I + +W Sbjct: 273 CSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQIL-MLRMIMEGQYQFSSPEWDD 331 Query: 230 MTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFS 287 ++T +DL+ LL+ +P R++AE+ALQHP+F Sbjct: 332 R-------------------------SSTVKDLISRLLQVDPEARLTAEQALQHPFFE 364 >3UDB-A nrPDB Length = 317 Score = 240 bits (614), Expect = 4e-64, Method: Composition-based stats. Identities = 75/292 (25%), Positives = 127/292 (43%), Gaps = 30/292 (10%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 +YE ++ IG G +G ++++ +E+VA+K + + E + + REI + L+H Sbjct: 19 DRYELVKDIGAGNFGVARLMRDKQANELVAVKYI---ERGEKIDENVKREIINHRSLRHP 75 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN 121 NIVR +V+ + L +V E+ G + + F QL+ G+ + H+ Sbjct: 76 NIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYAHAMQ 135 Query: 122 VLHRDLKPQNLLINRN--GELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLY 179 V HRDLK +N L++ + LK+ADFG ++A + + SA V T Y P+VL + Sbjct: 136 VAHRDLKLENTLLDGSPAPRLKIADFGYSKASVLHSQPKSA-VGTPAYIAPEVLLKKEYD 194 Query: 180 STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPY 239 D+WS G + P + + K I R+L +PDY Sbjct: 195 GKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRIL--------NVQYAIPDYV-- 244 Query: 240 PMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCP 291 ++ R L+ + +P +RIS E H +F P Sbjct: 245 --------------HISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNLP 282 >3E3P-A nrPDB Length = 360 Score = 240 bits (613), Expect = 5e-64, Method: Composition-based stats. Identities = 104/311 (33%), Positives = 158/311 (50%), Gaps = 27/311 (8%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKEL-- 58 M +++ G+GT+GTV K + T VA+K+V D P RE+ ++++L Sbjct: 22 MDRFQVERMAGQGTFGTVQLGKEKSTGMSVAIKKVIQD------PRFRNRELQIMQDLAV 75 Query: 59 -KHKNIVRLHDVLHS-------DKKLTLVFEFCDQDLKK---YFDSCNGDLDPEIVKSFL 107 H NIV+L ++ D L +V E+ L + + P ++K FL Sbjct: 76 LHHPNIVQLQSYFYTLGERDRRDIYLNVVMEYVPDTLHRCCRNYYRRQVAPPPILIKVFL 135 Query: 108 FQLLKGLGFCH--SRNVLHRDLKPQNLLINR-NGELKLADFGLARAFGIPVRCYSAEVVT 164 FQL++ +G H S NV HRD+KP N+L+N +G LKL DFG A+ P A + + Sbjct: 136 FQLIRSIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKLS-PSEPNVAYICS 194 Query: 165 LWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTE 224 +YR P+++FG + Y+T++D+WS GCIFAE+ G P+F G++ QL I R+LG P+ Sbjct: 195 RYYRAPELIFGNQHYTTAVDIWSVGCIFAEMM-LGEPIFRGDNSAGQLHEIVRVLGCPSR 253 Query: 225 EQWPSMTKLP---DYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEAL 281 E + D P + + K DLL LL+ P +R+ EAL Sbjct: 254 EVLRKLNPSHTDVDLYNSKGIPWSNVFSDHSLKDAKEAYDLLSALLQYLPEERMKPYEAL 313 Query: 282 QHPYFSDFCPP 292 HPYF + P Sbjct: 314 CHPYFDELHDP 324 >4CQG-A nrPDB Length = 331 Score = 240 bits (612), Expect = 7e-64, Method: Composition-based stats. Identities = 83/294 (28%), Positives = 129/294 (43%), Gaps = 33/294 (11%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 ++ YE E IG G + V A + T E+VA+K + + +P EI LK L+H Sbjct: 8 LKYYELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGSDLPR-VKTEIDALKSLRH 66 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 ++I +L+ VL + K+ +V E+C + L E + Q+L + + HS+ Sbjct: 67 QHICQLYHVLETKNKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQILSAVAYVHSQ 126 Query: 121 NVLHRDLKPQNLLINRNGELKLADFGL-ARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLY 179 HRDLKP+NLL + N +LKL DFGL A+ G +L Y P+++ G Sbjct: 127 GYAHRDLKPENLLFDENHKLKLIDFGLCAKPKGNKDYHLQECCGSLAYAAPELIQGKSYL 186 Query: 180 STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPY 239 + D+WS G + L P F ++V K+I R Sbjct: 187 GSEADVWSMGILLYVLMCGFLP-FDDDNVMALYKKIMR---------------------- 223 Query: 240 PMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPY-FSDFCPP 292 V L+ + LLQ +L+ +P +RIS L HP+ D+ P Sbjct: 224 -------GKYEVPKWLSPSSILLLQQMLQVDPKKRISMRNLLNHPWVMQDYSCP 270 >2F57-A nrPDB Length = 317 Score = 239 bits (611), Expect = 8e-64, Method: Composition-based stats. Identities = 70/284 (24%), Positives = 127/284 (44%), Gaps = 31/284 (10%) Query: 9 KIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHD 68 KIGEG+ G V A + T + VA+K++ L E+ ++++ H N+V ++ Sbjct: 52 KIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRR--ELLFNEVVIMRDYHHDNVVDMYS 109 Query: 69 VLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLK 128 +L +V EF + + + ++ E + + +L+ L + H++ V+HRD+K Sbjct: 110 SYLVGDELWVVMEFLEGGALTDIVT-HTRMNEEQIATVCLSVLRALSYLHNQGVIHRDIK 168 Query: 129 PQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSA 188 ++L+ +G +KL+DFG V + V T ++ P+V+ Y T +D+WS Sbjct: 169 SDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVI-SRLPYGTEVDIWSL 227 Query: 189 GCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSL 248 G + E+ + P F E +M ++ D P Sbjct: 228 GIMVIEMIDGEPPYF-------------------NEPPLQAMRRIRDSLP--------PR 260 Query: 249 VNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 292 V + K+++ R L +L P QR +A+E L HP+ PP Sbjct: 261 VKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPP 304 >4NIF-A nrPDB Length = 333 Score = 239 bits (611), Expect = 9e-64, Method: Composition-based stats. Identities = 70/292 (23%), Positives = 117/292 (40%), Gaps = 39/292 (13%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLL-KELKHKN 62 Y E IG G+Y + ++ T+ A+K + D EI +L + +H N Sbjct: 10 YVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPS------EEIEILLRYGQHPN 63 Query: 63 IVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNV 122 I+ L DV K + LV E L + K + + HS+ V Sbjct: 64 IITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGV 123 Query: 123 LHRDLKPQNLL-INRNGE---LKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL 178 +HRDLKP N+L ++ +G L++ DFG A+ T + P+VL + Sbjct: 124 VHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVL-KRQG 182 Query: 179 YSTSIDMWSAGCIFAELANAGRPLFPG--NDVDDQLKRIFRLLGTPTEEQWPSMTKLPDY 236 Y D+WS G + + P G + ++ L RI T + W ++ Sbjct: 183 YDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTV------ 236 Query: 237 KPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288 + T +DL+ +L +P QR++A++ LQHP+ + Sbjct: 237 -------------------SETAKDLVSKMLHVDPHQRLTAKQVLQHPWVTQ 269 >5D9K-A nrPDB Length = 330 Score = 239 bits (611), Expect = 1e-63, Method: Composition-based stats. Identities = 76/308 (24%), Positives = 131/308 (42%), Gaps = 49/308 (15%) Query: 3 KYEKLEKIGEGTYGTVFKAKNR---ETHEIVALKRVRLDDDDEGVPSSALREICLLKELK 59 ++E L+ +G+G++G VF K + ++ A+K ++ E +L E+ Sbjct: 31 QFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVN 90 Query: 60 HKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 H IV+LH ++ KL L+ +F S E VK +L +L L HS Sbjct: 91 HPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHS 150 Query: 120 RNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLY 179 +++RDLKP+N+L++ G +KL DFGL++ + + T+ Y P+V+ + + Sbjct: 151 LGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVV-NRRGH 209 Query: 180 STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPY 239 + S D WS G + E+ P F G D + + I + Sbjct: 210 TQSADWWSFGVLMFEMLTGTLP-FQGKDRKETMTMILK---------------------- 246 Query: 240 PMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISA-----EEALQHPYFS------- 287 + + + L+ + LL+ L K NP R+ A EE +H +FS Sbjct: 247 -------AKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKL 299 Query: 288 ---DFCPP 292 + PP Sbjct: 300 YRREIHPP 307 >4KS7-A nrPDB Length = 292 Score = 239 bits (611), Expect = 1e-63, Method: Composition-based stats. Identities = 68/278 (24%), Positives = 128/278 (46%), Gaps = 31/278 (11%) Query: 9 KIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHD 68 KIGEG+ G V A+ + + VA+K + L E+ ++++ +H N+V ++ Sbjct: 30 KIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRR--ELLFNEVVIMRDYQHFNVVEMYK 87 Query: 69 VLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLK 128 ++L ++ EF S L+ E + + +L+ L + H++ V+HRD+K Sbjct: 88 SYLVGEELWVLMEFLQGGALTDIVS-QVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIK 146 Query: 129 PQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSA 188 ++L+ +G +KL+DFG V + V T ++ P+V+ LY+T +D+WS Sbjct: 147 SDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVI-SRSLYATEVDIWSL 205 Query: 189 GCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSL 248 G + E+ + P F + V + RL +P + Sbjct: 206 GIMVIEMVDGEPPYFSDSPVQA----MKRLRDSPPPK----------------------- 238 Query: 249 VNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286 + K++ RD L+ +L +P +R +A+E L HP+ Sbjct: 239 LKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFL 276 >4D2V-A nrPDB Length = 356 Score = 239 bits (610), Expect = 1e-63, Method: Composition-based stats. Identities = 80/294 (27%), Positives = 128/294 (43%), Gaps = 33/294 (11%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 ++ YE E IG G + V A + T E+VA+K + + +P EI LK L+H Sbjct: 28 LKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPR-IKTEIEALKNLRH 86 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 ++I +L+ VL + K+ +V E+C + L E + Q++ + + HS+ Sbjct: 87 QHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQ 146 Query: 121 NVLHRDLKPQNLLINRNGELKLADFGL-ARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLY 179 HRDLKP+NLL + +LKL DFGL A+ G A L Y P+++ G Sbjct: 147 GYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQACCGALAYAAPELIQGKSYL 206 Query: 180 STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPY 239 + D+WS G + L P F + + +I R Sbjct: 207 GSEADVWSMGILLYVLMCGFLP-FDDDTAAALVAKIMR---------------------- 243 Query: 240 PMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF-SDFCPP 292 +V L+ + LLQ +L+ +P +RIS + L HP+ D+ P Sbjct: 244 -------GKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYP 290 >4RLP-A nrPDB Length = 288 Score = 238 bits (609), Expect = 1e-63, Method: Composition-based stats. Identities = 73/294 (24%), Positives = 121/294 (41%), Gaps = 41/294 (13%) Query: 4 YEKLEKIGEGTYGTVF---KAKNRETHEIVALKRVRLDD--DDEGVPSSALREICLLKEL 58 +E L +G+G YG VF K T +I A+K ++ + + E +L+E+ Sbjct: 7 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEV 66 Query: 59 KHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCH 118 KH IV L + KL L+ E+ G + +L ++ LG H Sbjct: 67 KHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLH 126 Query: 119 SRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL 178 + +++RDLKP+N+++N G +KL DFGL + T+ Y P++L Sbjct: 127 QKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILM-RSG 185 Query: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKP 238 ++ ++D WS G + ++ P F G + + +I + Sbjct: 186 HNRAVDWWSLGALMYDMLTGA-PPFTGENRKKTIDKILKC-------------------- 224 Query: 239 YPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRIS-----AEEALQHPYFS 287 +N+ P L RDLL+ LLK N R+ A E HP+F Sbjct: 225 ---------KLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFR 269 >4PDS-A nrPDB Length = 347 Score = 238 bits (609), Expect = 2e-63, Method: Composition-based stats. Identities = 78/301 (25%), Positives = 128/301 (42%), Gaps = 43/301 (14%) Query: 2 QKYEKL-EKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 + + + E +G+G + TV KA R T + ++K + G RE+ +L++L H Sbjct: 30 KDFSIIDEVVGQGAFATVKKAIERTTGKTFSVKIISKRKVI-GNMDGVTRELEVLQKLNH 88 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 IVRL + +V EF F + +G + + + Q+L + + HS Sbjct: 89 PRIVRLKGFYEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSM 148 Query: 121 NVLHRDLKPQNLLINRNGE--LKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL 178 + HRDLKP N+LI ++ +K+ FGLA+ G TL Y P+V+ G Sbjct: 149 GISHRDLKPDNILIEQDDPVLVKITAFGLAKVQGN-GSFMKTFCGTLAYVAPEVIRGKDT 207 Query: 179 ------------YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQ 226 YS+ +DMWS GC+ + P F G+ D K+I R G+ E Sbjct: 208 SVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLP-FSGSTQDQLYKQIGR--GSYHEGP 264 Query: 227 WPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286 +++ RD + +LL+ +P R +A +AL HP+ Sbjct: 265 LKDF-----------------------RISEEARDFIDSLLQVDPNNRSTAAKALNHPWI 301 Query: 287 S 287 Sbjct: 302 K 302 >3I6U-A nrPDB Length = 419 Score = 238 bits (608), Expect = 2e-63, Method: Composition-based stats. Identities = 69/298 (23%), Positives = 118/298 (39%), Gaps = 38/298 (12%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSA------LREICLL 55 +Y + +G G G V A R+T + VA++ + G A EI +L Sbjct: 135 DEYIMSKTLGSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSAREADPALNVETEIEIL 194 Query: 56 KELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLG 115 K+L H I+++ + ++ +V E + N L K + +Q+L + Sbjct: 195 KKLNHPCIIKIKNFFDAEDY-YIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQ 253 Query: 116 FCHSRNVLHRDLKPQNLLIN---RNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDV 172 + H ++HRDLKP+N+L++ + +K+ DFG ++ G T Y P+V Sbjct: 254 YLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILG-ETSLMRTLCGTPTYLAPEV 312 Query: 173 L--FGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSM 230 L G Y+ ++D WS G I + P +I E W Sbjct: 313 LVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWA-- 370 Query: 231 TKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288 +++ DL++ LL +P R + EEAL+HP+ D Sbjct: 371 -----------------------EVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQD 405 >6C9D-A nrPDB Length = 459 Score = 238 bits (608), Expect = 2e-63, Method: Composition-based stats. Identities = 66/287 (22%), Positives = 126/287 (43%), Gaps = 31/287 (10%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 Y + IG+G + V A++ T VA+K + + RE+ ++K L H NI Sbjct: 23 YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNI 82 Query: 64 VRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVL 123 V+L +V+ ++K L LV E+ + +G + + ++ Q++ + +CH + ++ Sbjct: 83 VKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIV 142 Query: 124 HRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSI 183 HRDLK +NLL++ + +K+ADFG + F + + Y P++ G K + Sbjct: 143 HRDLKAENLLLDGDMNIKIADFGFSNEFTV-GNKLDEFCGSPPYAAPELFQGKKYDGPEV 201 Query: 184 DMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYP 243 D+WS G I L + P F G ++ + +R+ R ++P Y Sbjct: 202 DVWSLGVILYTLVSGSLP-FDGQNLKELRERVLR-----------GKYRIPFYMSTDCEN 249 Query: 244 ATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFC 290 L+ + NP++R S E+ ++ + + Sbjct: 250 LLKKLLVL------------------NPIKRGSLEQIMKDRWMNVGH 278 >1PHK-A nrPDB Length = 298 Score = 238 bits (607), Expect = 2e-63, Method: Composition-based stats. Identities = 70/301 (23%), Positives = 125/301 (41%), Gaps = 40/301 (13%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLD-------DDDEGVPSSALREICL 54 + YE E +G G V + ++ T + A+K + + ++ + + + L+E+ + Sbjct: 17 ENYEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQELREATLKEVDI 76 Query: 55 LKELK-HKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKG 113 L+++ H NI++L D ++ LVF+ + + + L + + + LL+ Sbjct: 77 LRKVSGHPNIIQLKDTYETNTFFFLVFDLMKKGELFDYLTEKVTLSEKETRKIMRALLEV 136 Query: 114 LGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVL 173 + H N++HRDLKP+N+L++ + +KL DFG + P T Y P+++ Sbjct: 137 ICALHKLNIVHRDLKPENILLDDDMNIKLTDFGFSCQLD-PGEKLREVCGTPSYLAPEII 195 Query: 174 F-----GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWP 228 Y +DMWS G I L G P F L+ I +W Sbjct: 196 ECSMNDNHPGYGKEVDMWSTGVIMYTLLA-GSPPFWHRKQMLMLRMIMSGNYQFGSPEWD 254 Query: 229 SMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288 + T +DL+ L P +R +AEEAL HP+F Sbjct: 255 DY-------------------------SDTVKDLVSRFLVVQPQKRYTAEEALAHPFFQQ 289 Query: 289 F 289 + Sbjct: 290 Y 290 >2JAM-A nrPDB Length = 304 Score = 238 bits (607), Expect = 3e-63, Method: Composition-based stats. Identities = 73/288 (25%), Positives = 120/288 (41%), Gaps = 34/288 (11%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 + + +E +G G + VF K R T ++ ALK ++ SS EI +LK++KH+ Sbjct: 9 KTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPA--FRDSSLENEIAVLKKIKHE 66 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN 121 NIV L D+ S LV + G + + Q+L + + H Sbjct: 67 NIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHENG 126 Query: 122 VLHRDLKPQNLLI---NRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL 178 ++HRDLKP+NLL N ++ + DFGL++ + S T Y P+VL K Sbjct: 127 IVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGI--MSTACGTPGYVAPEVL-AQKP 183 Query: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKP 238 YS ++D WS G I L P + ++I W Sbjct: 184 YSKAVDCWSIGVITYILLCGYPPFYE-ETESKLFEKIKEGYYEFESPFWD---------- 232 Query: 239 YPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286 ++ + +D + +LL+ +P +R + E+AL HP+ Sbjct: 233 ---------------DISESAKDFICHLLEKDPNERYTCEKALSHPWI 265 >2HAK-A nrPDB Length = 328 Score = 238 bits (607), Expect = 3e-63, Method: Composition-based stats. Identities = 66/287 (22%), Positives = 126/287 (43%), Gaps = 31/287 (10%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 Y + IG+G + V A++ T VA+K + + RE+ ++K L H NI Sbjct: 17 YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNI 76 Query: 64 VRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVL 123 V+L +V+ ++K L LV E+ + +G + + ++ Q++ + +CH + ++ Sbjct: 77 VKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIV 136 Query: 124 HRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSI 183 HRDLK +NLL++ + +K+ADFG + F + + Y P++ G K + Sbjct: 137 HRDLKAENLLLDGDMNIKIADFGFSNEFTV-GNKLDTFCGSPPYAAPELFQGKKYDGPEV 195 Query: 184 DMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYP 243 D+WS G I L + P F G ++ + +R+ R ++P Y Sbjct: 196 DVWSLGVILYTLVSGSLP-FDGQNLKELRERVLR-----------GKYRIPFYMSTDCEN 243 Query: 244 ATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFC 290 L+ + NP++R S E+ ++ + + Sbjct: 244 LLKKLLVL------------------NPIKRGSLEQIMKDRWMNVGH 272 >2J90-A nrPDB Length = 304 Score = 237 bits (606), Expect = 3e-63, Method: Composition-based stats. Identities = 66/294 (22%), Positives = 118/294 (40%), Gaps = 36/294 (12%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVP----SSALREICLLKE 57 YE E++G G + V K + + T + A K ++ RE+ +L+E Sbjct: 26 DHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILRE 85 Query: 58 LKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFC 117 ++H NI+ LHD+ + + L+ E F + L + FL Q+L G+ + Sbjct: 86 IRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDGVHYL 145 Query: 118 HSRNVLHRDLKPQNLLINR----NGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVL 173 HS+ + H DLKP+N+++ N +KL DFG+A + T + P+++ Sbjct: 146 HSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEA-GNEFKNIFGTPEFVAPEIV 204 Query: 174 FGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKL 233 + DMWS G I L + P G + L I + EE Sbjct: 205 -NYEPLGLEADMWSIGVITYILLSGASPFL-GETKQETLTNISAVNYDFDEE-------- 254 Query: 234 PDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFS 287 + +D ++ LL +P +R++ ++L+H + Sbjct: 255 -----------------YFSNTSELAKDFIRRLLVKDPKRRMTIAQSLEHSWIK 291 >4B6L-A nrPDB Length = 281 Score = 237 bits (606), Expect = 4e-63, Method: Composition-based stats. Identities = 76/290 (26%), Positives = 119/290 (41%), Gaps = 32/290 (11%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDD-DDEGVPSSALREICLLKELKHKN 62 Y K +G+G + ++A + ET A+K + L EI L ++L+H++ Sbjct: 11 YLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRH 70 Query: 63 IVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNV 122 IVR + + E C + + L V+ +L Q+L GL + H R + Sbjct: 71 IVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGI 130 Query: 123 LHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTS 182 LHRDLK N I N ELK+ DFGLA P + T Y P+VL + + Sbjct: 131 LHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLL-RQGHGPE 189 Query: 183 IDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMY 242 D+WS GC+ L G P F D+ + + I ++ T Sbjct: 190 ADVWSLGCVMYTLLC-GSPPFETADLKETYRCIKQVHYTLPA------------------ 230 Query: 243 PATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 292 L+ R LL +L+ +P R S ++ L+H +F+ P Sbjct: 231 -----------SLSLPARQLLAAILRASPRDRPSIDQILRHDFFTKGYTP 269 >5ZTN-A nrPDB Length = 429 Score = 237 bits (605), Expect = 4e-63, Method: Composition-based stats. Identities = 88/328 (26%), Positives = 150/328 (45%), Gaps = 47/328 (14%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK- 61 +YE L+ IG+G++G V KA + + H+ VALK VR +++ A EI +L+ L+ + Sbjct: 98 RYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVR---NEKRFHRQAAEEIRILEHLRKQD 154 Query: 62 -----NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCN-GDLDPEIVKSFLFQLLKGLG 115 N++ + + + + FE +L + +V+ F +L+ L Sbjct: 155 KDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLD 214 Query: 116 FCHSRNVLHRDLKPQNLLINRNGE--LKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVL 173 H ++H DLKP+N+L+ + G +K+ DFG + V Y + + +YR P+V+ Sbjct: 215 ALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTY---IQSRFYRAPEVI 271 Query: 174 FGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKL 233 GA+ Y IDMWS GCI AEL G PL PG D DQL + LLG P+++ + + Sbjct: 272 LGAR-YGMPIDMWSLGCILAELLT-GYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRA 329 Query: 234 PDYKPYPMYPATTSLVNVVPK------------------------------LNATGRDLL 263 ++ YP ++ + + D L Sbjct: 330 KNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFL 389 Query: 264 QNLLKCNPVQRISAEEALQHPYFSDFCP 291 + L+ +P R++ +AL+HP+ P Sbjct: 390 KQCLEWDPAVRMTPGQALRHPWLRRRLP 417 >3EB0-A nrPDB Length = 383 Score = 237 bits (605), Expect = 5e-63, Method: Composition-based stats. Identities = 101/327 (30%), Positives = 159/327 (48%), Gaps = 50/327 (15%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 +KY + +G G++G V + + E+ + ALK+V D P RE+ ++K L H Sbjct: 7 KKYSLGKTLGTGSFGIVCEVFDIESGKRFALKKVLQD------PRYKNRELDIMKVLDHV 60 Query: 62 NIVRLHDVLHS--------------------------------------DKKLTLVFEFC 83 NI++L D ++ +K L ++ E+ Sbjct: 61 NIIKLVDYFYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNVIMEYV 120 Query: 84 DQDLKKYFDS---CNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLIN-RNGE 139 L K S + ++ +++QL + +GF HS + HRD+KPQNLL+N ++ Sbjct: 121 PDTLHKVLKSFIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLLVNSKDNT 180 Query: 140 LKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAG 199 LKL DFG A+ IP A + + +YR P+++ GA Y+ SID+WS GC+F EL G Sbjct: 181 LKLCDFGSAKKL-IPSEPSVAYICSRFYRAPELMLGATEYTPSIDLWSIGCVFGELI-LG 238 Query: 200 RPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATG 259 +PLF G DQL RI +++GTPT+EQ M +P A + + Sbjct: 239 KPLFSGETSIDQLVRIIQIMGTPTKEQMIRMNPHYTEVRFPTLKAKDWRKILPEGTPSLA 298 Query: 260 RDLLQNLLKCNPVQRISAEEALQHPYF 286 DLL+ +L+ P RI+ EA+ HP+F Sbjct: 299 IDLLEQILRYEPDLRINPYEAMAHPFF 325 >3DB8-A nrPDB Length = 317 Score = 237 bits (604), Expect = 6e-63, Method: Composition-based stats. Identities = 68/293 (23%), Positives = 118/293 (40%), Gaps = 32/293 (10%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDD-DEGVPSSALREICLLKELK 59 M++Y + +G+G + ++ + +T E+ A K V EI + K L Sbjct: 41 MKRYMRGRFLGKGGFAKCYEITDMDTKEVFAGKVVPKSMLLKPHQKEKMSTEIAIHKSLD 100 Query: 60 HKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 + ++V H D + +V E C + + + F+ Q ++G+ + H+ Sbjct: 101 NPHVVGFHGFFEDDDFVYVVLEICRRRSLLELHKRRKAVTEPEARYFMRQTIQGVQYLHN 160 Query: 120 RNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLY 179 V+HRDLK NL +N + ++K+ DFGLA T Y P+VL K + Sbjct: 161 NRVIHRDLKLGNLFLNDDMDVKIGDFGLATKIEFDGERKKDLCGTPNYIAPEVL-CKKGH 219 Query: 180 STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPY 239 S +D+WS GCI L G+P F + + + RI + Sbjct: 220 SFEVDIWSLGCILYTLLV-GKPPFETSCLKETYIRIKK---------------------- 256 Query: 240 PMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 292 + +V +N L++ +L +P R S E L +F+ P Sbjct: 257 -------NEYSVPRHINPVASALIRRMLHADPTLRPSVAELLTDEFFTSGYAP 302 >3UC3-A nrPDB Length = 361 Score = 236 bits (603), Expect = 7e-63, Method: Composition-based stats. Identities = 71/292 (24%), Positives = 122/292 (41%), Gaps = 30/292 (10%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 +Y+ ++ IG G +G +++ T E+VA+K + + + + REI + L+H Sbjct: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYI---ERGAAIDENVQREIINHRSLRHP 76 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN 121 NIVR +V+ + L ++ E+ G + + F QLL G+ +CHS Sbjct: 77 NIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQ 136 Query: 122 VLHRDLKPQNLLINRN--GELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLY 179 + HRDLK +N L++ + LK+ DFG +++ + + S V T Y P+VL + Sbjct: 137 ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKST-VGTPAYIAPEVLLRQEYD 195 Query: 180 STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPY 239 D+WS G + P + D K I R+L +PD Sbjct: 196 GKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVK--------YSIPD---- 243 Query: 240 PMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCP 291 +++ L+ + +P RIS E H +F P Sbjct: 244 ------------DIRISPECCHLISRIFVADPATRISIPEIKTHSWFLKNLP 283 >2YAB-A nrPDB Length = 361 Score = 236 bits (603), Expect = 8e-63, Method: Composition-based stats. Identities = 70/292 (23%), Positives = 123/292 (42%), Gaps = 36/292 (12%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEG----VPSSALREICLLKELK 59 Y+ E++G G + V K + + T A K ++ RE+ +L+++ Sbjct: 14 YDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIEREVSILRQVL 73 Query: 60 HKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 H NI+ LHDV + + L+ E F + L E SF+ Q+L G+ + H+ Sbjct: 74 HPNIITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHT 133 Query: 120 RNVLHRDLKPQNL-LINRN---GELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFG 175 + + H DLKP+N+ L+++N +KL DFGLA V + T + P+++ Sbjct: 134 KKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVE-FKNIFGTPEFVAPEIV-N 191 Query: 176 AKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPD 235 + DMWS G I L + P G+ + L I + EE Sbjct: 192 YEPLGLEADMWSIGVITYILLSGASPFL-GDTKQETLANITAVSYDFDEE---------- 240 Query: 236 YKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFS 287 + + +D ++ LL +R++ +EAL+HP+ + Sbjct: 241 ---------------FFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWIT 277 >1FOT-A nrPDB Length = 318 Score = 235 bits (601), Expect = 1e-62, Method: Composition-based stats. Identities = 59/294 (20%), Positives = 121/294 (41%), Gaps = 40/294 (13%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDE-GVPSSALREICLLKELK 59 +Q ++ L +G G++G V ++R A+K ++ + E +L + Sbjct: 5 LQDFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVT 64 Query: 60 HKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 H I+R+ +++ ++ ++ + + + K + ++ L + HS Sbjct: 65 HPFIIRMWGTFQDAQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYLHS 124 Query: 120 RNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLY 179 +++++RDLKP+N+L+++NG +K+ DFG A+ T Y P+V+ K Y Sbjct: 125 KDIIYRDLKPENILLDKNGHIKITDFGFAKYVPD---VTYTLCGTPDYIAPEVV-STKPY 180 Query: 180 STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPY 239 + SID WS G + E+ P + ++ ++I Sbjct: 181 NKSIDWWSFGILIYEMLAGYTPFYD-SNTMKTYEKILN---------------------- 217 Query: 240 PMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRI-----SAEEALQHPYFSD 288 + + P N +DLL L+ + QR+ E+ HP+F + Sbjct: 218 -------AELRFPPFFNEDVKDLLSRLITRDLSQRLGNLQNGTEDVKNHPWFKE 264 >4JG6-A nrPDB Length = 355 Score = 235 bits (601), Expect = 1e-62, Method: Composition-based stats. Identities = 69/290 (23%), Positives = 118/290 (40%), Gaps = 39/290 (13%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLL-KELKHKN 62 YE E IG G+Y + ++ T+ A+K + D EI +L + +H N Sbjct: 37 YEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPT------EEIEILLRYGQHPN 90 Query: 63 IVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNV 122 I+ L DV K + +V E + LF + K + + H++ V Sbjct: 91 IITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGV 150 Query: 123 LHRDLKPQNLL-INRNGE---LKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL 178 +HRDLKP N+L ++ +G +++ DFG A+ T + P+VL + Sbjct: 151 VHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLE-RQG 209 Query: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDV--DDQLKRIFRLLGTPTEEQWPSMTKLPDY 236 Y + D+WS G + + P G D ++ L RI + + W S+ Sbjct: 210 YDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSV------ 263 Query: 237 KPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286 + T +DL+ +L +P QR++A L+HP+ Sbjct: 264 -------------------SDTAKDLVSKMLHVDPHQRLTAALVLRHPWI 294 >5F9E-A nrPDB Length = 353 Score = 235 bits (599), Expect = 2e-62, Method: Composition-based stats. Identities = 69/291 (23%), Positives = 128/291 (43%), Gaps = 34/291 (11%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDD--DDEGVPSSALREICLLKEL 58 ++ +E + +G+G++G VF A+ ++T++ A+K ++ D D+ V + + + L Sbjct: 18 IEDFELHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAW 77 Query: 59 KHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCH 118 +H + + + + L V E+ + Y D + +++ GL F H Sbjct: 78 EHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLH 137 Query: 119 SRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL 178 S+ +++RDLK N+L++++G +K+ADFG+ + + + T Y P++L G K Sbjct: 138 SKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNEFCGTPDYIAPEILLGQK- 196 Query: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKP 238 Y+ S+D WS G + E+ P F G D ++ I Sbjct: 197 YNHSVDWWSFGVLLYEMLIGQSP-FHGQDEEELFHSI--------------------RMD 235 Query: 239 YPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAE-EALQHPYFSD 288 P YP L +DLL L P +R+ + QHP F + Sbjct: 236 NPFYPRW---------LEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFRE 277 >3Q53-A nrPDB Length = 306 Score = 235 bits (599), Expect = 2e-62, Method: Composition-based stats. Identities = 75/290 (25%), Positives = 125/290 (43%), Gaps = 31/290 (10%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 +KY + EKIG+G GTV+ A + T + VA++++ L + + EI +++E K+ Sbjct: 21 KKYTRFEKIGQGASGTVYTAMDVATGQEVAIRQMNLQQQPKK--ELIINEILVMRENKNP 78 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN 121 NIV D +L +V E+ + +D + + + L+ L F HS Sbjct: 79 NIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTET-CMDEGQIAAVCRECLQALEFLHSNQ 137 Query: 122 VLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYST 181 V+HRD+K N+L+ +G +KL DFG S V T ++ P+V+ K Y Sbjct: 138 VIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVV-TRKAYGP 196 Query: 182 SIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPM 241 +D+WS G + E+ P + + P Y + Sbjct: 197 KVDIWSLGIMAIEMIEGEPPY---------------------------LNENPLRALYLI 229 Query: 242 YPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCP 291 T + KL+A RD L L+ + +R SA+E +QH + P Sbjct: 230 ATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELIQHQFLKIAKP 279 >4I6B-A nrPDB Length = 308 Score = 234 bits (598), Expect = 3e-62, Method: Composition-based stats. Identities = 64/292 (21%), Positives = 122/292 (41%), Gaps = 32/292 (10%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDD-DDEGVPSSALREICLLKELKH 60 ++Y + + +G+G + ++ + +++ A K + +EI L + L H Sbjct: 28 KRYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKIDKEIELHRILHH 87 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 K++V+ + + + ++ E+C + + L V+ +L Q++ GL + H + Sbjct: 88 KHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQ 147 Query: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYS 180 +LHRDLK N IN + ELK+ DFGLA T Y P+VL + + Sbjct: 148 EILHRDLKLGNFFINESMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVL-NKQGHG 206 Query: 181 TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYP 240 D+W+ GC+ + GRP F ++ + + I T Sbjct: 207 AESDIWALGCVMYTML-LGRPPFETTNLKETYRSIREARYT------------------- 246 Query: 241 MYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 292 + L A + L+ ++L NP R S ++ ++H +F+ P Sbjct: 247 ----------MPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFFTQGFTP 288 >6FDY-U nrPDB Length = 276 Score = 233 bits (596), Expect = 4e-62, Method: Composition-based stats. Identities = 86/295 (29%), Positives = 137/295 (46%), Gaps = 32/295 (10%) Query: 1 MQKYEKLEKIGEGTYGTVFKAK-NRETHEIVALKRVRLDDDDEGVPSSALREICLLKELK 59 + + E++G GTY TV+KA ++T E+VA+K V ++ + L EI +LK ++ Sbjct: 10 LDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKGIR 69 Query: 60 HKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 H +IV+L D + L+ EFC F L ++ + F+ QL L F H Sbjct: 70 HPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFLHE 129 Query: 120 RNVLHRDLKPQNLLIN--RNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAK 177 RN+ H DLKPQN+L++ LKLADFG A+ + + Y P+++ + Sbjct: 130 RNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKH-VLRGSPLYMAPEMV-CQR 187 Query: 178 LYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYK 237 Y +D+WS G I E G+P F + ++I + + +LP Sbjct: 188 QYDARVDLWSMGVILYEALF-GQPPFASRSFSELEEKI----------RSNRVIELP--- 233 Query: 238 PYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 292 + P L+ RDLLQ LL+ +P +RIS ++ HP+ P Sbjct: 234 -------------LRPLLSRDCRDLLQRLLERDPSRRISFQDFFAHPWVDLEHMP 275 >2XIK-A nrPDB Length = 294 Score = 233 bits (596), Expect = 5e-62, Method: Composition-based stats. Identities = 69/287 (24%), Positives = 125/287 (43%), Gaps = 32/287 (11%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 + KL++IG+G++G V+K + T E+VA+K + L++ + +EI +L + I Sbjct: 21 FTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAE-DEIEDIQQEITVLSQCDSPYI 79 Query: 64 VRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVL 123 R KL ++ E+ G L+ + + L ++LKGL + HS + Sbjct: 80 TRYFGSYLKSTKLWIIMEYLGGGSALDLLKP-GPLEETYIATILREILKGLDYLHSERKI 138 Query: 124 HRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSI 183 HRD+K N+L++ G++KLADFG+A + V T ++ P+V+ + Y Sbjct: 139 HRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQS-AYDFKA 197 Query: 184 DMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYP 243 D+WS G ELA P + D R+ L+ + P Sbjct: 198 DIWSLGITAIELAKGEPP-----NSDLHPMRVLFLIPKNSPPTLEGQHSKP--------- 243 Query: 244 ATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFC 290 ++ ++ L +P R +A+E L+H + + + Sbjct: 244 ---------------FKEFVEACLNKDPRFRPTAKELLKHKFITRYT 275 >3F3Z-A nrPDB Length = 277 Score = 233 bits (596), Expect = 5e-62, Method: Composition-based stats. Identities = 81/292 (27%), Positives = 124/292 (42%), Gaps = 35/292 (11%) Query: 1 MQKYEKLE-KIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELK 59 + +Y LE IG G++G V A + T A K++ ++ +EI ++K L Sbjct: 7 INQYYTLENTIGRGSWGEVKIAVQKGTRIRRAAKKIPKYFVEDVDR--FKQEIEIMKSLD 64 Query: 60 HKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 H NI+RL++ + + LV E C + +L + +CH Sbjct: 65 HPNIIRLYETFEDNTDIYLVMELCTGGELFERVVHKRVFRESDAARIMKDVLSAVAYCHK 124 Query: 120 RNVLHRDLKPQNLLI---NRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGA 176 NV HRDLKP+N L + + LKL DFGLA F P + +V T +Y P VL G Sbjct: 125 LNVAHRDLKPENFLFLTDSPDSPLKLIDFGLAARF-KPGKMMRTKVGTPYYVSPQVLEG- 182 Query: 177 KLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDY 236 LY D WSAG + L G P F + + +I T E+ W ++ Sbjct: 183 -LYGPECDEWSAGVMMYVLLC-GYPPFSAPTDSEVMLKIREGTFTFPEKDWLNV------ 234 Query: 237 KPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288 + L++ LL +P QRI++ +AL+H +F Sbjct: 235 -------------------SPQAESLIRRLLTKSPKQRITSLQALEHEWFEK 267 >3HDN-A nrPDB Length = 373 Score = 233 bits (596), Expect = 6e-62, Method: Composition-based stats. Identities = 67/291 (23%), Positives = 119/291 (40%), Gaps = 37/291 (12%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRV-RLDDDDEGVPSSALREI-CLLKELKH 60 + L+ IG+G++G V A+++ A+K + + + + E LLK +KH Sbjct: 39 DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKH 98 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 +V LH + KL V ++ + Y + + ++ LG+ HS Sbjct: 99 PFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSL 158 Query: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYS 180 N+++RDLKP+N+L++ G + L DFGL + S T Y P+VL + Y Sbjct: 159 NIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLH-KQPYD 217 Query: 181 TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYP 240 ++D W G + E+ G P F + + I Sbjct: 218 RTVDWWCLGAVLYEMLY-GLPPFYSRNTAEMYDNILNKP--------------------- 255 Query: 241 MYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAE----EALQHPYFS 287 + + P + + R LL+ LL+ + +R+ A+ E H +FS Sbjct: 256 --------LQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFS 298 >2Z7Q-A nrPDB Length = 321 Score = 233 bits (595), Expect = 6e-62, Method: Composition-based stats. Identities = 72/292 (24%), Positives = 128/292 (43%), Gaps = 39/292 (13%) Query: 4 YEKLEKIGEGTYGTVFKAKNR---ETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 +E L+ +G+G++G VF + ++ + A+K ++ E +L ++ H Sbjct: 30 FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNH 89 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 +V+LH ++ KL L+ +F S E VK +L +L GL HS Sbjct: 90 PFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSL 149 Query: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYS 180 +++RDLKP+N+L++ G +KL DFGL++ + + T+ Y P+V+ + +S Sbjct: 150 GIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVV-NRQGHS 208 Query: 181 TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYP 240 S D WS G + E+ P F G D + + I + Sbjct: 209 HSADWWSYGVLMFEMLTGSLP-FQGKDRKETMTLILK----------------------- 244 Query: 241 MYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRI-----SAEEALQHPYFS 287 + + + L+ + LL+ L K NP R+ AEE +H ++S Sbjct: 245 ------AKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYS 290 >1VZO-A nrPDB Length = 355 Score = 233 bits (595), Expect = 7e-62, Method: Composition-based stats. Identities = 67/301 (22%), Positives = 130/301 (43%), Gaps = 39/301 (12%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKN---RETHEIVALKRVRLDD--DDEGVPSSALREICLL 55 ++ +E L+ +G G YG VF + +T ++ A+K ++ E +L Sbjct: 53 IENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVL 112 Query: 56 KELK-HKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGL 114 + ++ +V LH ++ KL L+ ++ + S V+ ++ +++ L Sbjct: 113 EHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLAL 172 Query: 115 GFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYS-AEVVTLWYRPPDVL 173 H +++RD+K +N+L++ NG + L DFGL++ F + T+ Y PD++ Sbjct: 173 EHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYDFCGTIEYMAPDIV 232 Query: 174 F-GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTK 232 G + ++D WS G + EL P + + Q + R+L Sbjct: 233 RGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRIL------------- 279 Query: 233 LPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRIS-----AEEALQHPYFS 287 K P YP +++A +DL+Q LL +P +R+ A+E +H +F Sbjct: 280 ----KSEPPYPQ---------EMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQ 326 Query: 288 D 288 Sbjct: 327 K 327 >6ED6-A nrPDB Length = 415 Score = 233 bits (594), Expect = 9e-62, Method: Composition-based stats. Identities = 67/295 (22%), Positives = 124/295 (42%), Gaps = 36/295 (12%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRV-RLDDDDEGVPSSALREICLLKELKH 60 + Y+ ++ IG G +G V +++ + ++ A+K + + + + E ++ Sbjct: 88 EDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANS 147 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 +V+L D+ L +V E+ S N D+ + K + +++ L HS Sbjct: 148 PWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMS-NYDVPEKWAKFYTAEVVLALDAIHSM 206 Query: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCY-SAEVVTLWYRPPDVLF---GA 176 ++HRD+KP N+L++++G LKLADFG + V T Y P+VL G Sbjct: 207 GLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGGD 266 Query: 177 KLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDY 236 Y D WS G E+ P + + L+GT +K+ D+ Sbjct: 267 GFYGRECDWWSVGVFLYEMLVGDTPFYADS-----------LVGT--------YSKIMDH 307 Query: 237 KPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRI---SAEEALQHPYFSD 288 K +P +++ ++L+ L + R+ EE QHP+F + Sbjct: 308 KNSLCFPEDA-------EISKHAKNLICAFLT-DREVRLGRNGVEEIRQHPFFKN 354 >3GUB-A nrPDB Length = 295 Score = 233 bits (594), Expect = 9e-62, Method: Composition-based stats. Identities = 66/292 (22%), Positives = 119/292 (40%), Gaps = 36/292 (12%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVP----SSALREICLLKELK 59 Y+ E++G G + V K + + T A K ++ RE+ +LKE++ Sbjct: 13 YDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEIQ 72 Query: 60 HKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 H N++ LH+V + + L+ E F + L E FL Q+L G+ + HS Sbjct: 73 HPNVITLHEVYENKTDVILIGELVAGGELFDFLAEKESLTEEEATEFLKQILNGVYYLHS 132 Query: 120 RNVLHRDLKPQNLLINRNG----ELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFG 175 + H DLKP+N+++ +K+ DFGLA + T + P+++ Sbjct: 133 LQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDF-GNEFKNIFGTPEFVAPEIV-N 190 Query: 176 AKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPD 235 + DMWS G I L + P G+ + L + + +E Sbjct: 191 YEPLGLEADMWSIGVITYILLSGASPFL-GDTKQETLANVSAVNYEFEDE---------- 239 Query: 236 YKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFS 287 +A +D ++ LL +P +R++ +++LQHP+ Sbjct: 240 ---------------YFSNTSALAKDFIRRLLVKDPKKRMTIQDSLQHPWIK 276 >6HXF-B nrPDB Length = 302 Score = 233 bits (594), Expect = 9e-62, Method: Composition-based stats. Identities = 74/292 (25%), Positives = 126/292 (43%), Gaps = 34/292 (11%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 +E + ++G+G +G V+KAKN+ET + A K + + E + EI +L H I Sbjct: 21 WEIVGELGDGAFGKVYKAKNKETGALAAAKVI--ETKSEEELEDYIVEIEILATCDHPYI 78 Query: 64 VRLHDVLHSDKKLTLVFEFCDQDLKKYF-DSCNGDLDPEIVKSFLFQLLKGLGFCHSRNV 122 V+L + D KL ++ EFC + L ++ Q+L+ L F HS+ + Sbjct: 79 VKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKRI 138 Query: 123 LHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVL----FGAKL 178 +HRDLK N+L+ G+++LADFG++ ++ + + T ++ P+V+ Sbjct: 139 IHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTP 198 Query: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKP 238 Y D+WS G E+A P + L +I + Sbjct: 199 YDYKADIWSLGITLIEMAQIE-PPHHELNPMRVLLKIAK--------------------- 236 Query: 239 YPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFC 290 + + K + RD L+ L NP R SA + L+HP+ S Sbjct: 237 -----SDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSIT 283 >4QMW-A nrPDB Length = 310 Score = 233 bits (594), Expect = 1e-61, Method: Composition-based stats. Identities = 70/283 (24%), Positives = 127/283 (44%), Gaps = 32/283 (11%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 + KLEKIG+G++G VFK + T ++VA+K + L++ + +EI +L + + Sbjct: 31 FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAE-DEIEDIQQEITVLSQCDSPYV 89 Query: 64 VRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVL 123 + + D KL ++ E+ G LD + + L ++LKGL + HS + Sbjct: 90 TKYYGSYLKDTKLWIIMEYLGGGSALDLLEP-GPLDETQIATILREILKGLDYLHSEKKI 148 Query: 124 HRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSI 183 HRD+K N+L++ +GE+KLADFG+A + V T ++ P+V+ + Y + Sbjct: 149 HRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQS-AYDSKA 207 Query: 184 DMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYP 243 D+WS G ELA P + ++L + P++ Sbjct: 208 DIWSLGITAIELARGEPPHSELHP--------MKVLFLIPKNNPPTLEG----------- 248 Query: 244 ATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286 + ++ ++ L P R +A+E L+H + Sbjct: 249 ----------NYSKPLKEFVEACLNKEPSFRPTAKELLKHKFI 281 >3TKU-A nrPDB Length = 433 Score = 232 bits (593), Expect = 1e-61, Method: Composition-based stats. Identities = 62/298 (20%), Positives = 115/298 (38%), Gaps = 36/298 (12%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRV-RLDDDDEGVPSSALREICLLKELKH 60 + +E ++ IG G +G V K + T I A+K + + + + E +L Sbjct: 90 EDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDC 149 Query: 61 KNIVRLHDVLHSDKKLTLVFEF-CDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 + I LH + L LV ++ DL L ++ + ++ +++ + H Sbjct: 150 QWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIHQ 209 Query: 120 RNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSA-EVVTLWYRPPDVLF---- 174 + +HRD+KP N+L++ NG ++LADFG S+ V T Y P++L Sbjct: 210 LHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQAMED 269 Query: 175 GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLP 234 G Y D WS G E+ P + + + +I Sbjct: 270 GMGKYGPECDWWSLGVCMYEMLYGETPFYA-ESLVETYGKIMN----------------- 311 Query: 235 DYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRI---SAEEALQHPYFSDF 289 + + V ++ +DL+Q L C+ +R+ E+ +H +F Sbjct: 312 -------HEERFQFPSHVTDVSEEAKDLIQR-LICSRERRLGQNGIEDFKKHAFFEGL 361 >4AW2-A nrPDB Length = 437 Score = 232 bits (592), Expect = 1e-61, Method: Composition-based stats. Identities = 68/299 (22%), Positives = 119/299 (39%), Gaps = 36/299 (12%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRV-RLDDDDEGVPSSALREICLLKELKH 60 + +E L+ IG G +G V K + ++ A+K + + + + E +L Sbjct: 74 EDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDS 133 Query: 61 KNIVRLHDVLHSDKKLTLVFEF-CDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 K I LH D L LV ++ DL L E+ + +L +++ + H Sbjct: 134 KWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEEMARFYLAEMVIAIDSVHQ 193 Query: 120 RNVLHRDLKPQNLLINRNGELKLADFGLA-RAFGIPVRCYSAEVVTLWYRPPDVLF---- 174 + +HRD+KP N+L++ NG ++LADFG + S V T Y P++L Sbjct: 194 LHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMEG 253 Query: 175 GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLP 234 G Y D WS G E+ P + E + K+ Sbjct: 254 GKGRYGPECDWWSLGVCMYEMLYGETPFY-------------------AESLVETYGKIM 294 Query: 235 DYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRI---SAEEALQHPYFSDFC 290 ++K +P + ++ +DL++ L C+ R+ E+ +HP+FS Sbjct: 295 NHKERFQFPTQVT------DVSENAKDLIRR-LICSREHRLGQNGIEDFKKHPFFSGID 346 >6E9W-A nrPDB Length = 443 Score = 232 bits (592), Expect = 1e-61, Method: Composition-based stats. Identities = 65/295 (22%), Positives = 120/295 (40%), Gaps = 36/295 (12%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRV-RLDDDDEGVPSSALREICLLKELKH 60 + YE ++ IG G +G V +++ T ++ A+K + + + + E ++ Sbjct: 102 EDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANS 161 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 +V+L D+ L +V E+ S N D+ + + + +++ L HS Sbjct: 162 PWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMS-NYDVPEKWARFYTAEVVLALDAIHSM 220 Query: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCY-SAEVVTLWYRPPDVLF---GA 176 +HRD+KP N+L++++G LKLADFG V T Y P+VL G Sbjct: 221 GFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGD 280 Query: 177 KLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDY 236 Y D WS G E+ P + + L+GT +K+ ++ Sbjct: 281 GYYGRECDWWSVGVFLYEMLVGDTPFYADS-----------LVGT--------YSKIMNH 321 Query: 237 KPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRI---SAEEALQHPYFSD 288 K +P ++ ++L+ L + R+ EE +H +F + Sbjct: 322 KNSLTFPDDND-------ISKEAKNLICAFLT-DREVRLGRNGVEEIKRHLFFKN 368 >2A27-A nrPDB Length = 321 Score = 232 bits (592), Expect = 2e-61, Method: Composition-based stats. Identities = 69/292 (23%), Positives = 123/292 (42%), Gaps = 36/292 (12%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVP----SSALREICLLKELK 59 Y+ E++G G + V K + + T A K ++ RE+ +L+++ Sbjct: 14 YDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVL 73 Query: 60 HKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 H N++ LHDV + + L+ E F + L E SF+ Q+L G+ + H+ Sbjct: 74 HHNVITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHT 133 Query: 120 RNVLHRDLKPQNL-LINRN---GELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFG 175 + + H DLKP+N+ L+++N +KL DFGLA V + T + P+++ Sbjct: 134 KKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVE-FKNIFGTPEFVAPEIV-N 191 Query: 176 AKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPD 235 + DMWS G I L + P G+ + L I + EE Sbjct: 192 YEPLGLEADMWSIGVITYILLSGASPFL-GDTKQETLANITAVSYDFDEE---------- 240 Query: 236 YKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFS 287 + + +D ++ LL +R++ +EAL+HP+ + Sbjct: 241 ---------------FFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWIT 277 >3TXO-A nrPDB Length = 353 Score = 232 bits (592), Expect = 2e-61, Method: Composition-based stats. Identities = 64/298 (21%), Positives = 124/298 (41%), Gaps = 39/298 (13%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDD-DEGVPSSALREICLLKELK 59 + +E + +G+G++G V A+ +ET ++ A+K ++ D + + E +L + Sbjct: 22 IDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLAR 81 Query: 60 -HKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCH 118 H + +L + +L V EF + + + D + + +++ L F H Sbjct: 82 NHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLH 141 Query: 119 SRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL 178 + +++RDLK N+L++ G KLADFG+ + + T Y P++L L Sbjct: 142 DKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEIL-QEML 200 Query: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKP 238 Y ++D W+ G + E+ P F + DD + I L D Sbjct: 201 YGPAVDWWAMGVLLYEMLCGHAP-FEAENEDDLFEAI-----------------LNDEVV 242 Query: 239 YPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISA------EEALQHPYFSDFC 290 YP + L+ +L++ + NP R+ + L+HP+F + Sbjct: 243 YPTW------------LHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEID 288 >3DAK-A nrPDB Length = 290 Score = 232 bits (591), Expect = 2e-61, Method: Composition-based stats. Identities = 69/300 (23%), Positives = 116/300 (38%), Gaps = 34/300 (11%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 YE E IG G V A E VA+KR+ L+ + L+EI + + H Sbjct: 10 DDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDE-LLKEIQAMSQCHHP 68 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSC--------NGDLDPEIVKSFLFQLLKG 113 NIV + +L LV + +G LD + + L ++L+G Sbjct: 69 NIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEG 128 Query: 114 LGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPV-----RCYSAEVVTLWYR 168 L + H +HRD+K N+L+ +G +++ADFG++ + V T + Sbjct: 129 LEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWM 188 Query: 169 PPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWP 228 P+V+ + Y D+WS G ELA P P + Sbjct: 189 APEVMEQVRGYDFKADIWSFGITAIELATGAAPYHK---------------YPPMKVLML 233 Query: 229 SMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288 ++ P P ++ K + R ++ L+ +P +R +A E L+H +F Sbjct: 234 TLQNDP-----PSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQK 288 >3UTO-A nrPDB Length = 573 Score = 232 bits (591), Expect = 2e-61, Method: Composition-based stats. Identities = 73/295 (24%), Positives = 123/295 (41%), Gaps = 33/295 (11%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 + Y+ E++G G +G V + R T A K V E + +EI + L+H Sbjct: 156 LDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTP--HESDKETVRKEIQTMSVLRH 213 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCDQD-LKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 +V LHD D ++ +++EF L + + + + ++ Q+ KGL H Sbjct: 214 PTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMRQVCKGLCHMHE 273 Query: 120 RNVLHRDLKPQNLLIN--RNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAK 177 N +H DLKP+N++ R+ ELKL DFGL P + T + P+V G K Sbjct: 274 NNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLD-PKQSVKVTTGTAEFAAPEVAEG-K 331 Query: 178 LYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYK 237 DMWS G + L + P F G + D+ L+ + Sbjct: 332 PVGYYTDMWSVGVLSYILLSGLSP-FGGENDDETLRNVKSC------------------- 371 Query: 238 PYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 292 + ++ G+D ++ LL +P R++ +AL+HP+ + P Sbjct: 372 ------DWNMDDSAFSGISEDGKDFIRKLLLADPNTRMTIHQALEHPWLTPGNAP 420 >1ZWS-A nrPDB Length = 288 Score = 231 bits (590), Expect = 3e-61, Method: Composition-based stats. Identities = 69/292 (23%), Positives = 122/292 (41%), Gaps = 36/292 (12%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVP----SSALREICLLKELK 59 Y+ E++G G + V K + + T A K ++ RE+ +L+++ Sbjct: 14 YDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVL 73 Query: 60 HKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 H N++ LHDV + + L+ E F + L E SF+ Q+L G+ + H+ Sbjct: 74 HHNVITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHT 133 Query: 120 RNVLHRDLKPQNL-LINRN---GELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFG 175 + + H DLKP+N+ L+++N +KL DFGLA V + T + P+++ Sbjct: 134 KKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVE-FKNIFGTPEFVAPEIV-N 191 Query: 176 AKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPD 235 + DMWS G I L + P G+ + L I + EE Sbjct: 192 YEPLGLEADMWSIGVITYILLSGASPFL-GDTKQETLANITSVSYDFDEE---------- 240 Query: 236 YKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFS 287 + +D ++ LL +R++ +EAL+HP+ + Sbjct: 241 ---------------FFSHTSELAKDFIRKLLVKETRKRLTIQEALRHPWIT 277 >4APC-A nrPDB Length = 350 Score = 230 bits (588), Expect = 5e-61, Method: Composition-based stats. Identities = 75/284 (26%), Positives = 124/284 (43%), Gaps = 32/284 (11%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 M+KY +L+KIGEG++G K+ E +K + + + RE+ +L +KH Sbjct: 23 MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKH 82 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCD-QDLKKYFDSCNGDL-DPEIVKSFLFQLLKGLGFCH 118 NIV+ + + L +V ++C+ DL K ++ G L + + + Q+ L H Sbjct: 83 PNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVH 142 Query: 119 SRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL 178 R +LHRD+K QN+ + ++G ++L DFG+AR V A + T +Y P++ K Sbjct: 143 DRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARACIGTPYYLSPEICEN-KP 201 Query: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKP 238 Y+ D+W+ GC+ EL G+ + LK I Sbjct: 202 YNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKII----------------------- 238 Query: 239 YPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQ 282 + S V + R L+ L K NP R S L+ Sbjct: 239 ------SGSFPPVSLHYSYDLRSLVSQLFKRNPRDRPSVNSILE 276 >5D7A-A nrPDB Length = 308 Score = 230 bits (586), Expect = 7e-61, Method: Composition-based stats. Identities = 73/298 (24%), Positives = 129/298 (43%), Gaps = 44/298 (14%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKEL-KHKN 62 +E +E +G GTYG V+K ++ +T ++ A+K + + D+E +EI +LK+ H+N Sbjct: 19 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEE---EEIKQEINMLKKYSHHRN 75 Query: 63 IVRLHDVLHS------DKKLTLVFEFCD-QDLKKYFDSCNGD-LDPEIVKSFLFQLLKGL 114 I + D +L LV EFC + + G+ L E + ++L+GL Sbjct: 76 IATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGL 135 Query: 115 GFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLF 174 H V+HRD+K QN+L+ N E+KL DFG++ V + + T ++ P+V+ Sbjct: 136 SHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIA 195 Query: 175 GAKL----YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSM 230 + Y D+WS G E+A PL Sbjct: 196 CDENPDATYDFKSDLWSLGITAIEMAEGAPPL---------------------------- 227 Query: 231 TKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288 + + + P + K + + +++ L N QR + E+ ++HP+ D Sbjct: 228 CDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRD 285 >1KOA-A nrPDB Length = 491 Score = 230 bits (586), Expect = 7e-61, Method: Composition-based stats. Identities = 73/295 (24%), Positives = 123/295 (41%), Gaps = 33/295 (11%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 + Y+ E++G G +G V + R T A K V E + +EI + L+H Sbjct: 50 LDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTP--HESDKETVRKEIQTMSVLRH 107 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCDQD-LKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 +V LHD D ++ +++EF L + + + + ++ Q+ KGL H Sbjct: 108 PTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMRQVCKGLCHMHE 167 Query: 120 RNVLHRDLKPQNLLIN--RNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAK 177 N +H DLKP+N++ R+ ELKL DFGL P + T + P+V G K Sbjct: 168 NNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLD-PKQSVKVTTGTAEFAAPEVAEG-K 225 Query: 178 LYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYK 237 DMWS G + L + P F G + D+ L+ + Sbjct: 226 PVGYYTDMWSVGVLSYILLSGLSP-FGGENDDETLRNVKSC------------------- 265 Query: 238 PYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 292 + ++ G+D ++ LL +P R++ +AL+HP+ + P Sbjct: 266 ------DWNMDDSAFSGISEDGKDFIRKLLLADPNTRMTIHQALEHPWLTPGNAP 314 >4YNZ-A nrPDB Length = 342 Score = 230 bits (586), Expect = 8e-61, Method: Composition-based stats. Identities = 73/282 (25%), Positives = 127/282 (45%), Gaps = 31/282 (10%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 Y + +G+G G V + T + VA+K V + E V REI +LK ++H ++ Sbjct: 12 YRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHV 71 Query: 64 VRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVL 123 ++LHDV + K L LV E + G L P+ + F Q++ L FCHS ++ Sbjct: 72 LKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSIC 131 Query: 124 HRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSI 183 HRDLKP+NLL++ +++ADFG+A + + Y P+V+ G K Sbjct: 132 HRDLKPENLLLDERNNIRIADFGMAS-LQVGDSLLETSCGSPHYACPEVIRGEKYDGRKA 190 Query: 184 DMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYP 243 D+WS G I L P F +++ L+++ R + +P + P Sbjct: 191 DVWSCGVILFALLVGALP-FDDDNLRQLLEKVKR-----------GVFHMPHFIP----- 233 Query: 244 ATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPY 285 + LL+ +++ + +R++ E +H + Sbjct: 234 -------------PDCQSLLRGMIEVDAARRLTLEHIQKHIW 262 >5JZN-A nrPDB Length = 280 Score = 229 bits (584), Expect = 1e-60, Method: Composition-based stats. Identities = 73/291 (25%), Positives = 122/291 (41%), Gaps = 33/291 (11%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 ++Y+ IG+G + V + R T ALK ++ G E+ +L+ +KH Sbjct: 19 ERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCR-GKEHMIQNEVSILRRVKHP 77 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN 121 NIV L + + +L LV E + L+ L + + HS N Sbjct: 78 NIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLYNLASAIKYLHSLN 137 Query: 122 VLHRDLKPQNLLI----NRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAK 177 ++HRD+KP+NLL+ + + LKL DFGLA P+ T Y P+++ Sbjct: 138 IVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGPLY---TVCGTPTYVAPEII-AET 193 Query: 178 LYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYK 237 Y +D+W+AG I L G P F G+ G E + + Sbjct: 194 GYGLKVDIWAAGVITYILLC-GFPPFRGS-------------GDDQEVLFDQILMGQVDF 239 Query: 238 PYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288 P P + ++ + ++L+ +L + QR SA + L+HP+ +D Sbjct: 240 PSPYWD----------NVSDSAKELITMMLLVDVDQRFSAVQVLEHPWVND 280 >6CMJ-A nrPDB Length = 321 Score = 229 bits (584), Expect = 1e-60, Method: Composition-based stats. Identities = 70/300 (23%), Positives = 125/300 (41%), Gaps = 42/300 (14%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDD---------DDEGVPSSALRE 51 + +Y ++IG+G+YG V A N + A+K + G +E Sbjct: 33 LDQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGGCIQPRGPIEQVYQE 92 Query: 52 ICLLKELKHKNIVRLHDVLHS--DKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQ 109 I +LK+L H N+V+L +VL + L +VFE +Q + L + + + Sbjct: 93 IAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLK-PLSEDQARFYFQD 151 Query: 110 LLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRP 169 L+KG+ + H + ++HRD+KP NLL+ +G +K+ADFG++ F S V T + Sbjct: 152 LIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMA 211 Query: 170 PDVLFGAKLY--STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQW 227 P+ L + ++D+W+ G P +D+++ + + + E Sbjct: 212 PESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPF-----MDERIMCLHSKIKSQALEFP 266 Query: 228 PSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFS 287 P + +DL+ +L NP RI E HP+ + Sbjct: 267 DQ-----------------------PDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVT 303 >4FZF-B nrPDB Length = 283 Score = 229 bits (584), Expect = 1e-60, Method: Composition-based stats. Identities = 67/283 (23%), Positives = 124/283 (43%), Gaps = 32/283 (11%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 + KLE+IG+G++G VFK + T ++VA+K + L++ + +EI +L + + Sbjct: 10 FTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAE-DEIEDIQQEITVLSQCDSSYV 68 Query: 64 VRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVL 123 + + KL ++ E+ G D + + L ++LKGL + HS + Sbjct: 69 TKYYGSYLKGSKLWIIMEYLGGGSALDLLRA-GPFDEFQIATMLKEILKGLDYLHSEKKI 127 Query: 124 HRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSI 183 HRD+K N+L++ G++KLA FG+A + V T ++ P+V+ + Y + Sbjct: 128 HRDIKAANVLLSEQGDVKLAAFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQS-AYDSKA 186 Query: 184 DMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYP 243 D+WS G ELA P + D R+ L+ Sbjct: 187 DIWSLGITAIELAKGEPP-----NSDMHPMRVLFLI------------------------ 217 Query: 244 ATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286 + +V + ++ + L +P R +A+E L+H + Sbjct: 218 PKNNPPTLVGDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFI 260 >5LOH-A nrPDB Length = 341 Score = 228 bits (583), Expect = 1e-60, Method: Composition-based stats. Identities = 65/295 (22%), Positives = 117/295 (39%), Gaps = 37/295 (12%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDD-DEGVPSSALREICLLKELK 59 ++++ ++ I G +G V+ + + ++ A+K V+ D ++ + E L K Sbjct: 35 IEEFSIVKPISRGAFGKVYLGQ--KGGKLYAVKVVKKADMINKNMTHQVQAERDALALSK 92 Query: 60 HKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 IV L+ L S + LV E+ K G D E+ ++ ++ L + H Sbjct: 93 SPFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALALDYLHR 152 Query: 120 RNVLHRDLKPQNLLINRNGELKLADFGLARAF------GIPVRCYSAEVVTLWYRPPDVL 173 ++HRDLKP N+LI+ G +KL DFGL++ + + T Y P++L Sbjct: 153 HGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILTTRTFCGTPDYLAPELL 212 Query: 174 FGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKL 233 G + + ++D W+ G E G P F + I + Sbjct: 213 LG-RAHGPAVDWWALGVCLFEFLT-GIPPFNDETPQQVFQNILK---------------- 254 Query: 234 PDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288 KL+ + ++ LL + +R +E +HP FSD Sbjct: 255 ----------RDIPWPEGEEKLSDNAQSAVEILLTIDDTKRAGMKELKRHPLFSD 299 >3A8W-A nrPDB Length = 345 Score = 228 bits (583), Expect = 2e-60, Method: Composition-based stats. Identities = 62/296 (20%), Positives = 121/296 (40%), Gaps = 30/296 (10%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLD--DDDEGVPSSALREICLLKEL 58 +Q ++ L IG G+Y V + ++T I A+K V+ + +DDE + + + Sbjct: 8 LQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQAS 67 Query: 59 KHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCH 118 H +V LH ++ +L V E+ + + L E + + ++ L + H Sbjct: 68 NHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLH 127 Query: 119 SRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL 178 R +++RDLK N+L++ G +KL D+G+ + P S T Y P++L G Sbjct: 128 ERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGED- 186 Query: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKP 238 Y S+D W+ G + E+ P ++G+ + + Sbjct: 187 YGFSVDWWALGVLMFEMMAGRSPF--------------DIVGSSDNPDQNT-------ED 225 Query: 239 YPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISA------EEALQHPYFSD 288 Y + + L+ +L++ L +P +R+ + HP+F + Sbjct: 226 YLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRN 281 >4CSV-A nrPDB Length = 275 Score = 228 bits (582), Expect = 2e-60, Method: Composition-based stats. Identities = 63/285 (22%), Positives = 121/285 (42%), Gaps = 39/285 (13%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62 + K+G G +G V++ K R + VA+K ++ L+E ++K+LKH N Sbjct: 12 EITLERKLGSGQFGEVYEGKWRNYNIEVAVKTLKEGTMS---VEEFLQEAQIMKKLKHPN 68 Query: 63 IVRLHDVLHSDKKLTLVFEFCD-QDLKKYFDSCNG-DLDPEIVKSFLFQLLKGLGFCHSR 120 +V+L+ V + + ++ E+ L Y C G ++ + + Q+ G+ + S+ Sbjct: 69 LVQLYGVCTKEPPIYIITEYMSHGSLLDYLRDCEGHTVNAQALLDMAAQVASGMAYLESQ 128 Query: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLW---YRPPDVLFGAK 177 N +HRDL +N L+ N +K+ADFGLAR Y+A + + P+ + + Sbjct: 129 NFIHRDLAARNCLVGENNVVKVADFGLARLINED--EYTARAGAKFPIKWTAPEAISYNR 186 Query: 178 LYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYK 237 +S D+W+ G + E+ G+ +PG + ++++ R P + P Sbjct: 187 -FSIKSDVWAFGILLWEIFTYGQVPYPGMSGSEVIEQVERGYRMPRPQGCP--------- 236 Query: 238 PYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQ 282 +L+ +P +R + E L Sbjct: 237 -------------------EEIYELMLQCWNKSPEERPTFAETLH 262 >2OU7-A nrPDB Length = 335 Score = 228 bits (582), Expect = 2e-60, Method: Composition-based stats. Identities = 67/284 (23%), Positives = 113/284 (39%), Gaps = 32/284 (11%) Query: 10 IGEGTYGTVFKAKNRETHEIVALKRVRLDDD-DEGVPSSALREICLLKELKHKNIVRLHD 68 +G+G + F+ + +T E+ A K V EI + + L H+++V H Sbjct: 49 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 108 Query: 69 VLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLK 128 + + +V E C + L + +L Q++ G + H V+HRDLK Sbjct: 109 FFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLK 168 Query: 129 PQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSA 188 NL +N + E+K+ DFGLA T Y P+VL K +S +D+WS Sbjct: 169 LGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVL-SKKGHSFEVDVWSI 227 Query: 189 GCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSL 248 GCI L G+P F + + + RI + + Sbjct: 228 GCIMYTLLV-GKPPFETSCLKETYLRIKK-----------------------------NE 257 Query: 249 VNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 292 ++ +N L+Q +L+ +P R + E L +F+ P Sbjct: 258 YSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIP 301 >5DBX-A nrPDB Length = 328 Score = 227 bits (580), Expect = 4e-60, Method: Composition-based stats. Identities = 72/298 (24%), Positives = 118/298 (39%), Gaps = 34/298 (11%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 YE E IG G V A + E VA+KR+ L+ + L+EI + + H N+ Sbjct: 13 YELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDE-LLKEIQAMSQCSHPNV 71 Query: 64 VRLHDVLHSDKKLTLVFEFCDQDLKKYF--------DSCNGDLDPEIVKSFLFQLLKGLG 115 V + +L LV + + NG L+ I+ + L ++L+GL Sbjct: 72 VTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGLD 131 Query: 116 FCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPV-----RCYSAEVVTLWYRPP 170 + H +HRDLK N+L+ +G +++ADFG++ + V T + P Sbjct: 132 YLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKDFVGTPCWMAP 191 Query: 171 DVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSM 230 +V+ + Y DMWS G ELA P P + ++ Sbjct: 192 EVMEQVRGYDFKADMWSFGITAIELATGAAPYHK---------------YPPMKVLMLTL 236 Query: 231 TKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288 P P ++ K + R LL L+ +P +R +A E L+ +F Sbjct: 237 QNDP-----PTLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQK 289 >3IS5-A nrPDB Length = 285 Score = 227 bits (579), Expect = 5e-60, Method: Composition-based stats. Identities = 73/292 (25%), Positives = 120/292 (41%), Gaps = 38/292 (13%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 + K+G G +G V + R + +K + D + EI +LK L H NI Sbjct: 24 FIFKRKLGSGAFGDVHLVEERSSGLERVIKTIN-KDRSQVPMEQIEAEIEVLKSLDHPNI 82 Query: 64 VRLHDVLHSDKKLTLVFEFCDQD-LKKYFDSCNGD---LDPEIVKSFLFQLLKGLGFCHS 119 +++ +V + +V E C+ L + S L V + Q++ L + HS Sbjct: 83 IKIFEVFEDYHNMYIVMETCEGGELLERIVSAQARGKALSEGYVAELMKQMMNALAYFHS 142 Query: 120 RNVLHRDLKPQNLLINR---NGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGA 176 ++V+H+DLKP+N+L + +K+ DFGLA F +A T Y P+V Sbjct: 143 QHVVHKDLKPENILFQDTSPHSPIKIIDFGLAELFKSDEHSTNA-AGTALYMAPEVF--K 199 Query: 177 KLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDY 236 + + D+WSAG + L P F G +++ Q + K P+Y Sbjct: 200 RDVTFKCDIWSAGVVMYFLLTGCLP-FTGTSLEEV--------------QQKATYKEPNY 244 Query: 237 KPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288 L DLL+ +L +P +R SA + L H +F Sbjct: 245 AVECR------------PLTPQAVDLLKQMLTKDPERRPSAAQVLHHEWFKQ 284 >4J52-A nrPDB Length = 293 Score = 227 bits (578), Expect = 6e-60, Method: Composition-based stats. Identities = 67/284 (23%), Positives = 113/284 (39%), Gaps = 32/284 (11%) Query: 10 IGEGTYGTVFKAKNRETHEIVALKRVRLDDD-DEGVPSSALREICLLKELKHKNIVRLHD 68 +G+G + F+ + +T E+ A K V EI + + L H+++V H Sbjct: 22 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 81 Query: 69 VLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLK 128 + + +V E C + L + +L Q++ G + H V+HRDLK Sbjct: 82 FFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLK 141 Query: 129 PQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSA 188 NL +N + E+K+ DFGLA T Y P+VL K +S +D+WS Sbjct: 142 LGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVL-SKKGHSFEVDVWSI 200 Query: 189 GCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSL 248 GCI L G+P F + + + RI + + Sbjct: 201 GCIMYTLLV-GKPPFETSCLKETYLRIKK-----------------------------NE 230 Query: 249 VNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 292 ++ +N L+Q +L+ +P R + E L +F+ P Sbjct: 231 YSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIP 274 >5N23-A nrPDB Length = 352 Score = 227 bits (578), Expect = 6e-60, Method: Composition-based stats. Identities = 63/293 (21%), Positives = 123/293 (41%), Gaps = 39/293 (13%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRV-RLDDDDEGVPSSALREICLLKELK 59 + ++E++ +G G++G V K++ET A+K + + L E + + + Sbjct: 41 LDQFERIRTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRIQQAVN 100 Query: 60 HKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 +V+L + L +V E+ G + + Q++ + HS Sbjct: 101 FPFLVKLEFSFKDNSNLYMVLEYAPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS 160 Query: 120 RNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLY 179 ++++RDLKP+NLLI++ G +K+ADFG A+ R T Y P+++ +K Y Sbjct: 161 LDLIYRDLKPENLLIDQQGYIKVADFGFAKRVK--GRTPWTLCGTPEYLAPEIIL-SKGY 217 Query: 180 STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPY 239 + ++D W+ G + E+A P F DQ +I+ + Sbjct: 218 NKAVDWWALGVLIYEMAAGYPPFFA-----DQPIQIYEKI-------------------- 252 Query: 240 PMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRI-----SAEEALQHPYFS 287 + V ++ +DLL+NLL+ + +R + H +F+ Sbjct: 253 -----VSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFA 300 >4B8L-A nrPDB Length = 286 Score = 226 bits (576), Expect = 1e-59, Method: Composition-based stats. Identities = 79/288 (27%), Positives = 136/288 (47%), Gaps = 34/288 (11%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRV-RLDDDDEGVPSSALREICLLKELK 59 + ++ +G+G +G V+ A+ ++ I+ALK + + + EGV REI + L+ Sbjct: 14 IDDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRREIEIQSHLR 73 Query: 60 HKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 H NI+R+++ H K++ L+ EF + +G D + +F+ +L L +CH Sbjct: 74 HPNILRMYNYFHDRKRIYLMLEFAPRGELYKELQKHGRFDEQRSATFMEELADALHYCHE 133 Query: 120 RNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLY 179 R V+HRD+KP+NLL+ GELK+ADFG + P TL Y PP+++ G K + Sbjct: 134 RKVIHRDIKPENLLMGYKGELKIADFGWS--VHAPSLRRRTMCGTLDYLPPEMIEG-KTH 190 Query: 180 STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPY 239 +D+W AG + E G P F + +RI + Sbjct: 191 DEKVDLWCAGVLCYEFLV-GMPPFDSPSHTETHRRIVNV--------------------- 228 Query: 240 PMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFS 287 + P L+ +DL+ LL+ +P QR+ + ++HP+ Sbjct: 229 --------DLKFPPFLSDGSKDLISKLLRYHPPQRLPLKGVMEHPWVK 268 >5X3F-B nrPDB Length = 393 Score = 225 bits (575), Expect = 1e-59, Method: Composition-based stats. Identities = 59/293 (20%), Positives = 123/293 (41%), Gaps = 40/293 (13%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRV-RLDDDDEGVPSSALREICLLKELK 59 + ++++++ +G G++G V K++E+ A+K + + L E +L+ + Sbjct: 83 LDQFDRIKTLGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVN 142 Query: 60 HKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 +V+L + L +V E+ G + + Q++ + HS Sbjct: 143 FPFLVKLEFSFKDNSNLYMVMEYVAGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS 202 Query: 120 RNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLY 179 ++++RDLKP+NLLI++ G +++ DFG A+ T Y P+++ +K Y Sbjct: 203 LDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG---RTWTLCGTPEYLAPEIIL-SKGY 258 Query: 180 STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPY 239 + ++D W+ G + E+A P F DQ +I+ + Sbjct: 259 NKAVDWWALGVLIYEMAAGYPPFFA-----DQPIQIYEKI-------------------- 293 Query: 240 PMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRI-----SAEEALQHPYFS 287 + V ++ +DLL+NLL+ + +R + H +F+ Sbjct: 294 -----VSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFA 341 >4RA4-A nrPDB Length = 355 Score = 225 bits (575), Expect = 1e-59, Method: Composition-based stats. Identities = 60/294 (20%), Positives = 117/294 (39%), Gaps = 38/294 (12%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDD-DDEGVPSSALREICLLKELK 59 + + L +G+G++G V A + T E+ A+K ++ D + + E +L L Sbjct: 19 LTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLD 78 Query: 60 HK-NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCH 118 + +LH + +L V E+ + Y G + ++ GL F H Sbjct: 79 KPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLH 138 Query: 119 SRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL 178 R +++RDLK N++++ G +K+ADFG+ + + T Y P+++ + Sbjct: 139 KRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEII-AYQP 197 Query: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKP 238 Y S+D W+ G + E+ G+P F G D D+ + I Sbjct: 198 YGKSVDWWAYGVLLYEMLA-GQPPFDGEDEDELFQSIME--------------------- 235 Query: 239 YPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISA-----EEALQHPYFS 287 V+ L+ + + L+ +P +R+ + +H +F Sbjct: 236 --------HNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFR 281 >6O6Q-A nrPDB Length = 335 Score = 225 bits (574), Expect = 2e-59, Method: Composition-based stats. Identities = 86/296 (29%), Positives = 151/296 (51%), Gaps = 20/296 (6%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKEL-KH 60 + YE L K+G G Y VF + E E V +K ++ + REI +LK L Sbjct: 41 ENYEILRKLGRGKYSEVFLGIDLEKREKVVIKVLKPVKRKK-----IKREISILKNLVDG 95 Query: 61 KNIVRLHDVLHSDKKLT--LVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCH 118 NI+ + DV+ + T L+FE + F S ++ ++++LLK L + H Sbjct: 96 PNIIAMLDVVREPQSKTPGLIFEHINNI---DFRSLYPTFTDYDIRFYMYELLKALDYSH 152 Query: 119 SRNVLHRDLKPQNLLINRNGEL-KLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAK 177 S ++HRD+KP N++I+ + +L +L D+GLA + P Y+ V + +++ P++L + Sbjct: 153 SMGIMHRDVKPHNVMIDHDKKLLRLIDWGLA-EYYHPGTEYNVRVASRYFKGPELLVDYR 211 Query: 178 LYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKL---P 234 LY S+DMWS GC+ A + P F G DQL +I R+LG+ +++ + Sbjct: 212 LYDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQLVQIVRVLGSKNFKKYLEKYNISLGE 271 Query: 235 DYKPYPMYPATTSLVNVVPK----LNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286 +Y+ Y + + ++ DL+ LL+ + +R++A+EA++H YF Sbjct: 272 EYEDIGYYNKRQWVRFMNENNKDLVSQEFLDLIDRLLRYDHQERLTAKEAMKHAYF 327 >6CQF-A nrPDB Length = 297 Score = 224 bits (572), Expect = 3e-59, Method: Composition-based stats. Identities = 85/284 (29%), Positives = 137/284 (48%), Gaps = 29/284 (10%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 Y+ L+++G GTYG VFKA+++ + ++VALK V+++ DD+ S+ +EI +LK +H Sbjct: 16 DHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDD--VSTLQKEILILKTCRHA 73 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN 121 NIV H +KL + EFC + G L + ++L+GL + HS+ Sbjct: 74 NIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSQK 133 Query: 122 VLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDV--LFGAKLY 179 +HRD+K N+LIN GE++LADFG++ G + A + T ++ P+V + Y Sbjct: 134 KIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLAFIGTPYWMAPEVAAVALKGGY 193 Query: 180 STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPY 239 + D+WS G ELA PLF D L T + Q P + + Sbjct: 194 NELCDIWSLGITAIELAELQPPLF------DVHPLRVLFLMTKSGYQPPRLKEKG----- 242 Query: 240 PMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQH 283 K +A + ++ L +P +R SA + L H Sbjct: 243 --------------KWSAAFHNFIKVTLTKSPKKRPSATKMLSH 272 >4WB7-A nrPDB Length = 405 Score = 224 bits (571), Expect = 3e-59, Method: Composition-based stats. Identities = 61/293 (20%), Positives = 123/293 (41%), Gaps = 40/293 (13%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRV-RLDDDDEGVPSSALREICLLKELK 59 + ++E+++ +G G++G V K++ET A+K + + L E +L+ + Sbjct: 95 LDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVN 154 Query: 60 HKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 +V+L + L +V E+ G + + Q++ + HS Sbjct: 155 FPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS 214 Query: 120 RNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLY 179 ++++RDLKP+NLLI++ G +++ DFG A+ T Y P+++ +K Y Sbjct: 215 LDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG---RTWTLCGTPEYLAPEIIL-SKGY 270 Query: 180 STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPY 239 + ++D W+ G + E+A P F DQ +I+ + Sbjct: 271 NKAVDWWALGVLIYEMAAGYPPFFA-----DQPIQIYEKI-------------------- 305 Query: 240 PMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRI-----SAEEALQHPYFS 287 + V ++ +DLL+NLL+ + +R + H +F+ Sbjct: 306 -----VSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFA 353 >2X4F-A nrPDB Length = 373 Score = 224 bits (571), Expect = 4e-59, Method: Composition-based stats. Identities = 74/284 (26%), Positives = 122/284 (42%), Gaps = 33/284 (11%) Query: 8 EKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLH 67 E +G G +G V K + T +A K ++ + EI ++ +L H N+++L+ Sbjct: 95 EILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDK--EEVKNEISVMNQLDHANLIQLY 152 Query: 68 DVLHSDKKLTLVFEFCDQD-LKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRD 126 D S + LV E+ D L + +L F+ Q+ +G+ H +LH D Sbjct: 153 DAFESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQMYILHLD 212 Query: 127 LKPQNLL-INRN-GELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSID 184 LKP+N+L +NR+ ++K+ DFGLAR + P T + P+V+ S D Sbjct: 213 LKPENILCVNRDAKQIKIIDFGLARRY-KPREKLKVNFGTPEFLAPEVV-NYDFVSFPTD 270 Query: 185 MWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPA 244 MWS G I L + P G++ + L I +E++ Sbjct: 271 MWSVGVIAYMLLSGLSPFL-GDNDAETLNNILACRWDLEDEEFQ---------------- 313 Query: 245 TTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288 ++ ++ + LL RISA EAL+HP+ SD Sbjct: 314 ---------DISEEAKEFISKLLIKEKSWRISASEALKHPWLSD 348 >1U5R-A nrPDB Length = 348 Score = 223 bits (570), Expect = 5e-59, Method: Composition-based stats. Identities = 67/292 (22%), Positives = 119/292 (40%), Gaps = 35/292 (11%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVP-SSALREICLLKELKHKN 62 + L +IG G++G V+ A++ E+VA+K++ ++E+ L++L+H N Sbjct: 56 FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPN 115 Query: 63 IVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNV 122 ++ + LV E+C + L + + L+GL + HS N+ Sbjct: 116 TIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHSHNM 175 Query: 123 LHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVL--FGAKLYS 180 +HRD+K N+L++ G +KL DFG A ++ V T ++ P+V+ Y Sbjct: 176 IHRDVKAGNILLSEPGLVKLGDFGSASIMA----PANSFVGTPYWMAPEVILAMDEGQYD 231 Query: 181 TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYP 240 +D+WS G ELA PLF + L I + Sbjct: 232 GKVDVWSLGITCIELAERKPPLF-NMNAMSALYHIAQ----------------------- 267 Query: 241 MYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 292 S + R+ + + L+ P R ++E L+H + PP Sbjct: 268 ----NESPALQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPP 315 >5YV8-A nrPDB Length = 298 Score = 223 bits (570), Expect = 5e-59, Method: Composition-based stats. Identities = 70/315 (22%), Positives = 125/315 (39%), Gaps = 57/315 (18%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDD--------------------- 39 + +Y ++IG+G+YG V A N + A+K + Sbjct: 12 LNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPG 71 Query: 40 ---DDEGVPSSALREICLLKELKHKNIVRLHDVLHS--DKKLTLVFEFCDQDLKKYFDSC 94 G +EI +LK+L H N+V+L +VL + L +VFE +Q + Sbjct: 72 GCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTL 131 Query: 95 NGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIP 154 L + + + L+KG+ + H + ++HRD+KP NLL+ +G +K+ADFG++ F Sbjct: 132 K-PLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGS 190 Query: 155 VRCYSAEVVTLWYRPPDVLFGAKLY--STSIDMWSAGCIFAELANAGRPLFPGNDVDDQL 212 S V T + P+ L + ++D+W+ G P +D+++ Sbjct: 191 DALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPF-----MDERI 245 Query: 213 KRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPV 272 + + + E P + +DL+ +L NP Sbjct: 246 MCLHSKIKSQALEFPDQ-----------------------PDIAEDLKDLITRMLDKNPE 282 Query: 273 QRISAEEALQHPYFS 287 RI E HP+ + Sbjct: 283 SRIVVPEIKLHPWVT 297 >2HW6-A nrPDB Length = 307 Score = 223 bits (569), Expect = 8e-59, Method: Composition-based stats. Identities = 67/299 (22%), Positives = 115/299 (38%), Gaps = 28/299 (9%) Query: 8 EKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELK-HKNIVRL 66 E +GEG Y V A + + + A+K + S RE+ L + + +KNI+ L Sbjct: 19 ELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSR--SRVFREVETLYQCQGNKNILEL 76 Query: 67 HDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRD 126 + D + LVFE + + + L F H++ + HRD Sbjct: 77 IEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKGIAHRD 136 Query: 127 LKPQNLLINRN---GELKLADFGLARAFGIPVRCY-------SAEVVTLWYRPPDVLF-- 174 LKP+N+L +K+ DF L + C + + Y P+V+ Sbjct: 137 LKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVF 196 Query: 175 --GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTK 232 A Y D+WS G + + + G P F G+ D + + + S+ + Sbjct: 197 TDQATFYDKRCDLWSLGVVLYIMLS-GYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQE 255 Query: 233 LPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCP 291 P + +++ +DL+ LL + QR+SA + LQHP+ P Sbjct: 256 GKYEFPDKDW----------AHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAP 304 >3ORZ-A nrPDB Length = 316 Score = 223 bits (568), Expect = 9e-59, Method: Composition-based stats. Identities = 69/299 (23%), Positives = 125/299 (41%), Gaps = 42/299 (14%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRV-RLDDDDEGVPSSALREICLLKELKH 60 + ++ + +GEG++ TV A+ T A+K + + E RE ++ L H Sbjct: 37 EDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDH 96 Query: 61 KNIVRLHDVLHSDKKLTLVFEFC-DQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 V+L+ D+KL + + +L KY G D + + +++ L + H Sbjct: 97 PFFVKLYFCFQDDEKLYFGLSYAKNGELLKYIRKI-GSFDETCTRFYTAEIVSALEYLHG 155 Query: 120 RNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRC--YSAEVVTLWYRPPDVLFGAK 177 + ++HRDLKP+N+L+N + +++ DFG A+ + ++ V T Y P++L Sbjct: 156 KGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKS 215 Query: 178 LYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYK 237 S D+W+ GCI +L G P F + ++I +L E+ +P Sbjct: 216 AC-KSSDLWALGCIIYQLVA-GLPPFRAGNEYLIFQKIIKLEYDFPEKFFP--------- 264 Query: 238 PYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEE------ALQHPYFSDFC 290 RDL++ LL + +R+ EE HP+F Sbjct: 265 --------------------KARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVT 303 >2VD5-A nrPDB Length = 412 Score = 222 bits (567), Expect = 1e-58, Method: Composition-based stats. Identities = 70/297 (23%), Positives = 112/297 (37%), Gaps = 38/297 (12%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRV-RLDDDDEGVPSSALREICLLKELKH 60 +E L+ IG G + V K ++T ++ A+K + + D G S E +L Sbjct: 61 DDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDR 120 Query: 61 KNIVRLHDVLHSDKKLTLVFEF-CDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 + I +LH + L LV E+ DL + E+ + +L +++ + H Sbjct: 121 RWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHR 180 Query: 120 RNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYS-AEVVTLWYRPPDVLFG--- 175 +HRD+KP N+L++R G ++LADFG S V T Y P++L Sbjct: 181 LGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAVGG 240 Query: 176 ---AKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTK 232 Y D W+ G E+ P + + + Sbjct: 241 GPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAET---------------------- 278 Query: 233 LPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRI---SAEEALQHPYF 286 Y Y SL V + RD +Q LL C P R+ A + HP+F Sbjct: 279 ---YGKIVHYKEHLSLPLVDEGVPEEARDFIQRLL-CPPETRLGRGGAGDFRTHPFF 331 >2GCD-A nrPDB Length = 309 Score = 222 bits (567), Expect = 1e-58, Method: Composition-based stats. Identities = 67/292 (22%), Positives = 119/292 (40%), Gaps = 35/292 (11%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVP-SSALREICLLKELKHKN 62 + L +IG G++G V+ A++ E+VA+K++ ++E+ L++L+H N Sbjct: 17 FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPN 76 Query: 63 IVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNV 122 ++ + LV E+C + L + + L+GL + HS N+ Sbjct: 77 TIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHSHNM 136 Query: 123 LHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVL--FGAKLYS 180 +HRD+K N+L++ G +KL DFG A ++ V T ++ P+V+ Y Sbjct: 137 IHRDVKAGNILLSEPGLVKLGDFGSASIMA----PANSFVGTPYWMAPEVILAMDEGQYD 192 Query: 181 TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYP 240 +D+WS G ELA PLF + L I + Sbjct: 193 GKVDVWSLGITCIELAERKPPLF-NMNAMSALYHIAQ----------------------- 228 Query: 241 MYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 292 S + R+ + + L+ P R ++E L+H + PP Sbjct: 229 ----NESPALQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPP 276 >1KOB-A nrPDB Length = 387 Score = 222 bits (567), Expect = 1e-58, Method: Composition-based stats. Identities = 62/290 (21%), Positives = 121/290 (41%), Gaps = 33/290 (11%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 Y+ LE++G G +G V + + T + K + + EI ++ +L H + Sbjct: 53 YDILEELGSGAFGVVHRCVEKATGRVFVAKFINTPY--PLDKYTVKNEISIMNQLHHPKL 110 Query: 64 VRLHDVLHSDKKLTLVFEFCDQD-LKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNV 122 + LHD ++ L+ EF L + + + V +++ Q +GL H ++ Sbjct: 111 INLHDAFEDKYEMVLILEFLSGGELFDRIAAEDYKMSEAEVINYMRQACEGLKHMHEHSI 170 Query: 123 LHRDLKPQNLLI--NRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYS 180 +H D+KP+N++ + +K+ DFGLA P T + P+++ + Sbjct: 171 VHLDIKPENIMCETKKASSVKIIDFGLATKLN-PDEIVKVTTATAEFAAPEIV-DREPVG 228 Query: 181 TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYP 240 DMW+ G + L + P F G D + L+ + R E+ + S+ Sbjct: 229 FYTDMWAIGVLGYVLLSGLSP-FAGEDDLETLQNVKRCDWEFDEDAFSSV---------- 277 Query: 241 MYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFC 290 + +D ++NLL+ P +R++ +AL+HP+ Sbjct: 278 ---------------SPEAKDFIKNLLQKEPRKRLTVHDALEHPWLKGDH 312 >3PFQ-A nrPDB Length = 674 Score = 220 bits (562), Expect = 4e-58, Method: Composition-based stats. Identities = 57/294 (19%), Positives = 116/294 (39%), Gaps = 38/294 (12%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLD--DDDEGVPSSALREICLLKEL 58 + + L +G+G++G V ++ + T E+ A+K ++ D D+ V + + + L Sbjct: 340 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 399 Query: 59 KHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCH 118 K + +LH + +L V E+ + Y G + ++ GL F Sbjct: 400 KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQ 459 Query: 119 SRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL 178 S+ +++RDLK N++++ G +K+ADFG+ + T Y P+++ + Sbjct: 460 SKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEII-AYQP 518 Query: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKP 238 Y S+D W+ G + E+ P F G D D+ + I Sbjct: 519 YGKSVDWWAFGVLLYEMLAGQAP-FEGEDEDELFQSIME--------------------- 556 Query: 239 YPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISA-----EEALQHPYFS 287 V ++ + + L+ +P +R+ + +H +F Sbjct: 557 --------HNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFR 602 >5DYK-A nrPDB Length = 853 Score = 220 bits (562), Expect = 5e-58, Method: Composition-based stats. Identities = 81/295 (27%), Positives = 125/295 (42%), Gaps = 37/295 (12%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALR-EICLLKELK 59 M + E IG GT+GTV ++ T ALK V + ++ E + E Sbjct: 538 MDELETERIIGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINLNQQNNIKLEREITAEND 597 Query: 60 HKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 H I+RL K + E G L + +L ++ + + H Sbjct: 598 HPFIIRLVRTFKDSKYFYFLTELVTGGELYDAIRKLGLLSKSQAQFYLGSIILAIEYLHE 657 Query: 120 RNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLY 179 RN+++RDLKP+N+L+++ G +KL DFG A+ R Y+ V T Y P+V+ G K Y Sbjct: 658 RNIVYRDLKPENILLDKQGYVKLIDFGCAKKVQ--GRAYT-LVGTPHYMAPEVILG-KGY 713 Query: 180 STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPY 239 ++D+W+ G E P GND +DQL+ IFR + T PDY Sbjct: 714 GCTVDIWALGICLYEFICGPLPF--GNDEEDQLE-IFRDILT-------GQLTFPDYVT- 762 Query: 240 PMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISA-----EEALQHPYFSDF 289 + +L++ LL P RI ++ HP+FS+F Sbjct: 763 ----------------DTDSINLMKRLLCRLPQGRIGCSINGFKDIKDHPFFSNF 801 >5KKR-C nrPDB Length = 395 Score = 220 bits (560), Expect = 7e-58, Method: Composition-based stats. Identities = 71/301 (23%), Positives = 131/301 (43%), Gaps = 19/301 (6%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 +EK+ ++G G G VFK ++ + ++A K + L+ + + +RE+ +L E Sbjct: 68 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE-IKPAIRNQIIRELQVLHECNSP 126 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFC-HSR 120 IV + +SD ++++ E D G + +I+ ++KGL + Sbjct: 127 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKH 186 Query: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYS 180 ++HRD+KP N+L+N GE+KL DFG++ + ++ V T Y P+ L G YS Sbjct: 187 KIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA--NSFVGTRSYMSPERLQGT-HYS 243 Query: 181 TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWP--------SMTK 232 D+WS G E+A P+ P + + +L ++ G E S Sbjct: 244 VQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYG 303 Query: 233 LPDYKPYPMYPATTSLVNVVPK------LNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286 + P ++ +VN P + +D + L NP +R ++ + H + Sbjct: 304 MDSRPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFI 363 Query: 287 S 287 Sbjct: 364 K 364 >3HKO-A nrPDB Length = 345 Score = 219 bits (559), Expect = 1e-57, Method: Composition-based stats. Identities = 87/340 (25%), Positives = 135/340 (39%), Gaps = 76/340 (22%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALR---EICLLKEL 58 +KY IG+G+YG V A +T I A+K + + + P R E+ L+K+L Sbjct: 26 KKYHLKGAIGQGSYGVVRVAIENQTRAIRAIKIMNKNKIRQINPKDVERIKTEVRLMKKL 85 Query: 59 KHKNIVRLHDVLHSDKKLTLVFEFCDQD-----LKKYFDSCNGDLDPEIVKS-------- 105 H NI RL++V ++ + LV E C L + D G ++VK+ Sbjct: 86 HHPNIARLYEVYEDEQYICLVMELCHGGHLLDKLNVFIDDSTGKCAMDVVKTQICPCPEC 145 Query: 106 ---------------------------FLFQLLKGLGFCHSRNVLHRDLKPQNLLI--NR 136 + Q+ L + H++ + HRD+KP+N L N+ Sbjct: 146 NEEAINGSIHGFRESLDFVQREKLISNIMRQIFSALHYLHNQGICHRDIKPENFLFSTNK 205 Query: 137 NGELKLADFGLARAF----GIPVRCYSAEVVTLWYRPPDVLF-GAKLYSTSIDMWSAGCI 191 + E+KL DFGL++ F + + T ++ P+VL + Y D WSAG + Sbjct: 206 SFEIKLVDFGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEVLNTTNESYGPKCDAWSAGVL 265 Query: 192 FAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNV 251 L P FPG + D + ++ + Sbjct: 266 LHLLLMGAVP-FPGVNDADTISQVLNKKLCFENPNYNV---------------------- 302 Query: 252 VPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCP 291 L+ RDLL NLL N +R A ALQHP+ S F Sbjct: 303 ---LSPLARDLLSNLLNRNVDERFDAMRALQHPWISQFSD 339 >5X8I-B nrPDB Length = 346 Score = 218 bits (557), Expect = 2e-57, Method: Composition-based stats. Identities = 78/327 (23%), Positives = 136/327 (41%), Gaps = 52/327 (15%) Query: 3 KYEKLEKIGEGTYGTVFKAK-NRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 +YE ++ +GEG +G V + ++ VA+K V+ D +A EI +L+ L Sbjct: 14 RYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVD---RYCEAARSEIQVLEHLNTT 70 Query: 62 N------IVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNG-DLDPEIVKSFLFQLLKGL 114 + V++ + + +VFE + + ++ +Q+ K + Sbjct: 71 DPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSV 130 Query: 115 GFCHSRNVLHRDLKPQNLLINR-------------------NGELKLADFGLARAFGIPV 155 F HS + H DLKP+N+L + N ++K+ DFG A Sbjct: 131 NFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSAT---YDD 187 Query: 156 RCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRI 215 +S V T YR P+V+ +S D+WS GCI E G +FP +D + L + Sbjct: 188 EHHSTLVSTRHYRAPEVILAL-GWSQPCDVWSIGCILIE-YYLGFTVFPTHDSKEHLAMM 245 Query: 216 FRLLGTPTEE----------------QWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATG 259 R+LG + W + Y P +++ + + Sbjct: 246 ERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQDVE-HERL 304 Query: 260 RDLLQNLLKCNPVQRISAEEALQHPYF 286 DL+Q +L+ +P +RI+ EAL+HP+F Sbjct: 305 FDLIQKMLEYDPAKRITLREALKHPFF 331 >4CRL-A nrPDB Length = 406 Score = 218 bits (555), Expect = 3e-57, Method: Composition-based stats. Identities = 115/321 (35%), Positives = 175/321 (54%), Gaps = 43/321 (13%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEI--VALKRVRLDDDDEGVPSSALREICLLKELKH 60 +YE + G GTYG V+KAK ++ + ALK++ + G+ SA REI LL+ELKH Sbjct: 24 EYEGCKV-GRGTYGHVYKAKRKDGKDDKDYALKQI----EGTGISMSACREIALLRELKH 78 Query: 61 KNIVRLHDVL--HSDKKLTLVFEFCDQDLKKYFDSCNG--------DLDPEIVKSFLFQL 110 N++ L V H+D+K+ L+F++ + DL L +VKS L+Q+ Sbjct: 79 PNVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQI 138 Query: 111 LKGLGFCHSRNVLHRDLKPQNLLIN----RNGELKLADFGLARAFGIPVRCYSAE---VV 163 L G+ + H+ VLHRDLKP N+L+ G +K+AD G AR F P++ + VV Sbjct: 139 LDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVV 198 Query: 164 TLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVD---------DQLKR 214 T WYR P++L GA+ Y+ +ID+W+ GCIFAEL + P+F D DQL R Sbjct: 199 TFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSE-PIFHCRQEDIKTSNPYHHDQLDR 257 Query: 215 IFRLLGTPTEEQWPSMTKLPDY---------KPYPMYPATTSLVNVVPKLNATGRDLLQN 265 IF ++G P ++ W + K+P++ Y + K ++ LLQ Sbjct: 258 IFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQK 317 Query: 266 LLKCNPVQRISAEEALQHPYF 286 LL +P++RI++E+A+Q PYF Sbjct: 318 LLTMDPIKRITSEQAMQDPYF 338 >2I0E-A nrPDB Length = 353 Score = 217 bits (554), Expect = 4e-57, Method: Composition-based stats. Identities = 57/294 (19%), Positives = 116/294 (39%), Gaps = 38/294 (12%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLD--DDDEGVPSSALREICLLKEL 58 + + L +G+G++G V ++ + T E+ A+K ++ D D+ V + + + L Sbjct: 19 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 78 Query: 59 KHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCH 118 K + +LH + +L V E+ + Y G + ++ GL F Sbjct: 79 KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQ 138 Query: 119 SRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL 178 S+ +++RDLK N++++ G +K+ADFG+ + T Y P+++ + Sbjct: 139 SKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEII-AYQP 197 Query: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKP 238 Y S+D W+ G + E+ P F G D D+ + I Sbjct: 198 YGKSVDWWAFGVLLYEMLAGQAP-FEGEDEDELFQSIME--------------------- 235 Query: 239 YPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISA-----EEALQHPYFS 287 V ++ + + L+ +P +R+ + +H +F Sbjct: 236 --------HNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFR 281 >6BDL-A nrPDB Length = 347 Score = 217 bits (554), Expect = 4e-57, Method: Composition-based stats. Identities = 62/296 (20%), Positives = 120/296 (40%), Gaps = 37/296 (12%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNR-ETHEIVALKRVRLDDDDEGVPSSALR-EICLLKEL 58 + + ++ +G G +G V + + E + A+K ++ + +R E +++ Sbjct: 33 LSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGA 92 Query: 59 KHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCH 118 IVRL+ K L ++ E C G + + + +++ + H Sbjct: 93 HSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLH 152 Query: 119 SRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL 178 S+ +++RDLKP+NL+++ G KL DFG A+ G + ++ T Y P+++ K Sbjct: 153 SKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWT-FCGTPEYVAPEIILN-KG 210 Query: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKP 238 + S D WS G + EL G P F G D I R + Sbjct: 211 HDISADYWSLGILMYELLT-GSPPFSGPDPMKTYNIILRGI------------------- 250 Query: 239 YPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRI-----SAEEALQHPYFSDF 289 ++ K+ +L++ L + NP +R+ ++ +H +F F Sbjct: 251 --------DMIEFPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGF 298 >4AF3-A nrPDB Length = 292 Score = 217 bits (554), Expect = 4e-57, Method: Composition-based stats. Identities = 74/288 (25%), Positives = 135/288 (46%), Gaps = 34/288 (11%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRV-RLDDDDEGVPSSALREICLLKELK 59 + +E +G+G +G V+ A+ +++H IVALK + + + EGV REI + L Sbjct: 22 IDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLH 81 Query: 60 HKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 H NI+RL++ + +++ L+ E+ + + D + + + +L L +CH Sbjct: 82 HPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHG 141 Query: 120 RNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLY 179 + V+HRD+KP+NLL+ GELK+ADFG + P TL Y PP+++ G +++ Sbjct: 142 KKVIHRDIKPENLLLGLKGELKIADFGWS--VHAPSLRRKTMCGTLDYLPPEMIEG-RMH 198 Query: 180 STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPY 239 + +D+W G + EL G P F ++ +RI ++ Sbjct: 199 NEKVDLWCIGVLCYELLV-GNPPFESASHNETYRRIVKV--------------------- 236 Query: 240 PMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFS 287 + + +DL+ LL+ NP +R+ + HP+ Sbjct: 237 --------DLKFPASVPTGAQDLISKLLRHNPSERLPLAQVSAHPWVR 276 >3ALO-A nrPDB Length = 327 Score = 217 bits (554), Expect = 4e-57, Method: Composition-based stats. Identities = 63/293 (21%), Positives = 120/293 (40%), Gaps = 33/293 (11%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 + + L +IG G YG+V K ++ + +I+A+KR+R D++ + +++ Sbjct: 22 EDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCP 81 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLD----PEIVKSFLFQLLKGLGFC 117 IV+ + L + + E K++ LD EI+ +K L Sbjct: 82 YIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHL 141 Query: 118 HSR-NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVL--- 173 ++HRD+KP N+L++R+G +KL DFG++ + + + Y P+ + Sbjct: 142 KENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQL-VDSIAKTRDAGCRPYMAPERIDPS 200 Query: 174 FGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKL 233 + Y D+WS G ELA P N V DQL ++ + G P + Sbjct: 201 ASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVK--GDPPQ--------- 249 Query: 234 PDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286 + + + + + + L + +R +E L+HP+ Sbjct: 250 -------------LSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFI 289 >3NYO-A nrPDB Length = 576 Score = 217 bits (553), Expect = 4e-57, Method: Composition-based stats. Identities = 64/294 (21%), Positives = 119/294 (40%), Gaps = 36/294 (12%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGV-PSSALREICLLKELKHKN 62 + + +G+G +G V + R T ++ A K++ + + AL E +L+++ + Sbjct: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRF 245 Query: 63 IVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGD--LDPEIVKSFLFQLLKGLGFCHSR 120 +V L + L LV + K+ G + ++ GL H Sbjct: 246 VVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRE 305 Query: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYS 180 +++RDLKP+N+L++ +G ++++D GLA + V T+ Y P+V+ + Y+ Sbjct: 306 RIVYRDLKPENILLDDHGHIRISDLGLAVHVP-EGQTIKGRVGTVGYMAPEVVKNER-YT 363 Query: 181 TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYP 240 S D W+ GC+ E+ P F + + + RL+ EE Sbjct: 364 FSPDWWALGCLLYEMIAGQSP-FQQRKKKIKREEVERLVKEVPEE--------------- 407 Query: 241 MYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRI-----SAEEALQHPYFSDF 289 + + R L LL +P +R+ SA E +HP F Sbjct: 408 ----------YSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKL 451 >3EQC-A nrPDB Length = 360 Score = 217 bits (553), Expect = 4e-57, Method: Composition-based stats. Identities = 70/301 (23%), Positives = 131/301 (43%), Gaps = 19/301 (6%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 +EK+ ++G G G VFK ++ + ++A K + L+ + + +RE+ +L E Sbjct: 33 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE-IKPAIRNQIIRELQVLHECNSP 91 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFC-HSR 120 IV + +SD ++++ E D G + +I+ ++KGL + Sbjct: 92 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKH 151 Query: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYS 180 ++HRD+KP N+L+N GE+KL DFG++ + ++ V T Y P+ L G YS Sbjct: 152 KIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA--NSFVGTRSYMSPERLQGT-HYS 208 Query: 181 TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWP--------SMTK 232 D+WS G E+A P+ P + + +L ++ G E + Sbjct: 209 VQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLNKFG 268 Query: 233 LPDYKPYPMYPATTSLVNVVPK------LNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286 + P ++ +VN P + +D + L NP +R ++ + H + Sbjct: 269 MDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFI 328 Query: 287 S 287 Sbjct: 329 K 329 >3KN6-A nrPDB Length = 325 Score = 217 bits (552), Expect = 7e-57, Method: Composition-based stats. Identities = 67/291 (23%), Positives = 116/291 (39%), Gaps = 41/291 (14%) Query: 8 EKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKEL-KHKNIVRL 66 + +GEG++ K ++++++ A+K + + + ++ +EI LK H NIV+L Sbjct: 17 KPLGEGSFSICRKCVHKKSNQAFAVKII-----SKRMEANTQKEITALKLCEGHPNIVKL 71 Query: 67 HDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRD 126 H+V H LV E + + +L+ + H V+HRD Sbjct: 72 HEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRD 131 Query: 127 LKPQNLLI---NRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSI 183 LKP+NLL N N E+K+ DFG AR + TL Y P++L Y S Sbjct: 132 LKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELL-NQNGYDESC 190 Query: 184 DMWSAGCIFAELANAGRPL------FPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYK 237 D+WS G I + + P + +K+I + + E W ++ Sbjct: 191 DLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNV------- 243 Query: 238 PYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288 + +DL+Q LL +P +R+ + + D Sbjct: 244 ------------------SQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQD 276 >2BRG-A nrPDB Length = 297 Score = 216 bits (551), Expect = 8e-57, Method: Composition-based stats. Identities = 72/290 (24%), Positives = 125/290 (43%), Gaps = 30/290 (10%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 ++ ++ ++ +GEG YG V A NR T E VA+K V + + P + +EIC+ K L H Sbjct: 6 VEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVD-CPENIKKEICINKMLNH 64 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 +N+V+ + L E+C + + + F QL+ G+ + H Sbjct: 65 ENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGI 124 Query: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAF--GIPVRCYSAEVVTLWYRPPDVLFGAKL 178 + HRD+KP+NLL++ LK++DFGLA F R + TL Y P++L + Sbjct: 125 GITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREF 184 Query: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKP 238 ++ +D+WS G + + P +D S + D+K Sbjct: 185 HAEPVDVWSCGIVLTAMLAGELPWDQPSD---------------------SCQEYSDWKE 223 Query: 239 YPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288 Y ++ P LL +L NP RI+ + + +++ Sbjct: 224 KKTYLNPWKKIDSAPLA------LLHKILVENPSARITIPDIKKDRWYNK 267 >5FET-A nrPDB Length = 847 Score = 216 bits (551), Expect = 9e-57, Method: Composition-based stats. Identities = 78/295 (26%), Positives = 123/295 (41%), Gaps = 37/295 (12%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALR-EICLLKELK 59 M + E IG GT+GTV ++ T ALK V + ++ E + E Sbjct: 532 MHELETERIIGRGTFGTVKLVHHKPTQIRYALKCVSKRSIISLNQQNNIKLEREITAEND 591 Query: 60 HKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 H I+RL + E G L + +L ++ + + H Sbjct: 592 HPFIIRLVRTFKDSNCFYFLTELVTGGELYDAIRKLGLLSKPQAQFYLGSIILAIEYLHE 651 Query: 120 RNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLY 179 RN+++RDLKP+N+L+++ G +KL DFG A+ R Y+ V T Y P+V+ G K Y Sbjct: 652 RNIVYRDLKPENILLDKQGYVKLIDFGCAKKIQ--GRAYT-LVGTPHYMAPEVILG-KGY 707 Query: 180 STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPY 239 ++D+W+ G E P GND +DQL+ IFR + T PDY Sbjct: 708 GCTVDIWALGVCLYEFICGPLPF--GNDQEDQLE-IFRDILT-------GQLTFPDYVS- 756 Query: 240 PMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISA-----EEALQHPYFSDF 289 + +L++ LL P RI ++ +H +F +F Sbjct: 757 ----------------DQDSINLMKRLLCRLPQGRIGCSINGFKDIKEHAFFGNF 795 >3VN9-A nrPDB Length = 340 Score = 216 bits (551), Expect = 9e-57, Method: Composition-based stats. Identities = 70/293 (23%), Positives = 122/293 (41%), Gaps = 35/293 (11%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 E + ++G G YG V K ++ + +I+A+KR+R + + + ++ + Sbjct: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCP 110 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDS---CNGDLDPEIVKSFLFQLLKGLGFCH 118 V + L + + + E D L K++ + +I+ ++K L H Sbjct: 111 FTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLH 170 Query: 119 SR-NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVL---F 174 S+ +V+HRD+KP N+LIN G++K+ DFG++ + + + Y P+ + Sbjct: 171 SKLSVIHRDVKPSNVLINALGQVKMCDFGISGYL-VDSVAKTIDAGCKPYMAPERINPEL 229 Query: 175 GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLP 234 K YS D+WS G ELA P QLK++ Sbjct: 230 NQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVE----------------- 272 Query: 235 DYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFS 287 +P P PA K +A D LK N +R + E +QHP+F+ Sbjct: 273 --EPSPQLPA--------DKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFT 315 >6E2O-A nrPDB Length = 295 Score = 215 bits (548), Expect = 2e-56, Method: Composition-based stats. Identities = 70/284 (24%), Positives = 121/284 (42%), Gaps = 34/284 (11%) Query: 9 KIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHD 68 +G+GTYG V+ ++ +A+K + + D EI L K LKHKNIV+ Sbjct: 29 VLGKGTYGIVYAGRDLSNQVRIAIKEIP--ERDSRYSQPLHEEIALHKHLKHKNIVQYLG 86 Query: 69 VLHSDKKLTLVFEFCDQD-LKKYFDSCNGDL--DPEIVKSFLFQLLKGLGFCHSRNVLHR 125 + + + E L S G L + + + + Q+L+GL + H ++HR Sbjct: 87 SFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHR 146 Query: 126 DLKPQNLLINR-NGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVL-FGAKLYSTSI 183 D+K N+LIN +G LK++DFG ++ C TL Y P+++ G + Y + Sbjct: 147 DIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAA 206 Query: 184 DMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYP 243 D+WS GC E+A P + E +M K+ +K +P P Sbjct: 207 DIWSLGCTIIEMATGKPPFYE------------------LGEPQAAMFKVGMFKVHPEIP 248 Query: 244 ATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFS 287 + ++A + + + +P +R A + L + Sbjct: 249 ES---------MSAEAKAFILKCFEPDPDKRACANDLLVDEFLK 283 >2WQN-A nrPDB Length = 310 Score = 215 bits (548), Expect = 2e-56, Method: Composition-based stats. Identities = 70/280 (25%), Positives = 112/280 (40%), Gaps = 32/280 (11%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRL-DDDDEGVPSSALREICLLKELK 59 + + +KIG G + V++A VALK+V++ D D + ++EI LLK+L Sbjct: 31 LANFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLN 90 Query: 60 HKNIVRLHDVLHSDKKLTLVFEFCDQD----LKKYFDSCNGDLDPEIVKSFLFQLLKGLG 115 H N+++ + D +L +V E D + K+F + V + QL L Sbjct: 91 HPNVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALE 150 Query: 116 FCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFG 175 HSR V+HRD+KP N+ I G +KL D GL R F + V T +Y P+ + Sbjct: 151 HMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIH- 209 Query: 176 AKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPD 235 Y+ D+WS GC+ E+A P + L + P Sbjct: 210 ENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLP---------- 259 Query: 236 YKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRI 275 + R L+ + +P +R Sbjct: 260 ----------------SDHYSEELRQLVNMCINPDPEKRP 283 >2PVN-A nrPDB Length = 352 Score = 215 bits (547), Expect = 2e-56, Method: Composition-based stats. Identities = 83/298 (27%), Positives = 143/298 (47%), Gaps = 19/298 (6%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 YE + K+G G Y VF+ N +E K + L Sbjct: 52 DDYEVVRKVGRGKYSEVFEGINVNNNE----KCIIKILKPVKKKKIKREIKILQNLCGGP 107 Query: 62 NIVRLHDVLHSD--KKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 NIV+L D++ K +L+FE+ + K L ++ ++++LLK L +CHS Sbjct: 108 NIVKLLDIVRDQHSKTPSLIFEYVNNTDFKVLY---PTLTDYDIRYYIYELLKALDYCHS 164 Query: 120 RNVLHRDLKPQNLLINRNGE-LKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL 178 + ++HRD+KP N++I+ L+L D+GLA F P + Y+ V + +++ P++L + Sbjct: 165 QGIMHRDVKPHNVMIDHELRKLRLIDWGLA-EFYHPGKEYNVRVASRYFKGPELLVDLQD 223 Query: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKL---PD 235 Y S+DMWS GC+FA + P F G+D DQL +I ++LGT + + ++ P Sbjct: 224 YDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKIAKVLGTDGLNAYLNKYRIELDPQ 283 Query: 236 YKPYPMYPATTSLVNVVPK-----LNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288 + + + + ++ D L LL+ + +R++A EA+ HPYF Sbjct: 284 LEALVGRHSRKPWLKFMNADNQHLVSPEAIDFLDKLLRYDHQERLTALEAMTHPYFQQ 341 >4U41-A nrPDB Length = 332 Score = 215 bits (547), Expect = 3e-56, Method: Composition-based stats. Identities = 74/298 (24%), Positives = 129/298 (43%), Gaps = 44/298 (14%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKEL-KHKN 62 +E +E +G GTYG V+K ++ +T ++ A+K + + +D+E EI +LK+ H+N Sbjct: 26 FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKL---EINMLKKYSHHRN 82 Query: 63 IVRLHDVLH------SDKKLTLVFEFCD-QDLKKYFDSCNGD-LDPEIVKSFLFQLLKGL 114 I + D +L LV EFC + + G+ L + + ++L+GL Sbjct: 83 IATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGL 142 Query: 115 GFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLF 174 H +V+HRD+K QN+L+ N E+KL DFG++ V + + T ++ P+V+ Sbjct: 143 AHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIA 202 Query: 175 GAKL----YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSM 230 + Y D+WS G E+A PL ++ +F + P Sbjct: 203 CDENPDATYDYRSDLWSCGITAIEMAEGAPPL----CDMHPMRALFLIPRNPPPRLKSKK 258 Query: 231 TKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288 + ++ L N +QR S E+ L+HP+ D Sbjct: 259 WSKKFFSF------------------------IEGCLVKNYMQRPSTEQLLKHPFIRD 292 >4C0T-A nrPDB Length = 974 Score = 214 bits (546), Expect = 3e-56, Method: Composition-based stats. Identities = 63/296 (21%), Positives = 116/296 (39%), Gaps = 42/296 (14%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRV-RLDDDDEGVPSSALREICLLKELKHK 61 ++ +++GEG+Y TV A ++ T + A+K + + E E L L ++ Sbjct: 267 DFKFGKELGEGSYSTVILATDKITGKQYAVKVLDKRHIIKEKKVKYVNIEKHALNRLSNR 326 Query: 62 -NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 ++ L+ L V ++ L+ E + F Q+L + + H Sbjct: 327 LGVISLYFTFQDKDSLYFVLDYASNGELLTLIKRYNTLNEECTRHFGAQILDAIKYMHDN 386 Query: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCY---------SAEVVTLWYRPPD 171 V+HRDLKP+N+L++ +++ DFG AR + V T Y P+ Sbjct: 387 GVIHRDLKPENILLDDKMRIQITDFGTARLLEKKNDESEEYPVDVRAKSFVGTAEYVSPE 446 Query: 172 VLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMT 231 +L K D+W+ GCI ++ G+P F + ++I +L Sbjct: 447 LLEN-KYCGKPGDVWAFGCIIYQMIA-GKPPFKATNEYLTFQKITKL------------- 491 Query: 232 KLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFS 287 + +P RDL++ +L P +R + E +H +F Sbjct: 492 ---QFAFSAGFPTII-------------RDLIKKILVLQPSRRATIPEIQKHYFFQ 531 >6HMD-A nrPDB Length = 365 Score = 213 bits (544), Expect = 6e-56, Method: Composition-based stats. Identities = 91/297 (30%), Positives = 152/297 (51%), Gaps = 21/297 (7%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 Y+ + K+G G Y VF+A N +E RV + RE+ +L+ L+ Sbjct: 53 DDYQLVRKLGRGKYSEVFEAINITNNE-----RVVVKILKPVKKKKIKREVKILENLRGG 107 Query: 62 -NIVRLHDVLHSD--KKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCH 118 NI++L D + K LVFE+ + K D D ++ ++++LLK L +CH Sbjct: 108 TNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFD---IRFYMYELLKALDYCH 164 Query: 119 SRNVLHRDLKPQNLLINRN-GELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAK 177 S+ ++HRD+KP N++I+ +L+L D+GLA F P + Y+ V + +++ P++L + Sbjct: 165 SKGIMHRDVKPHNVMIDHQQKKLRLIDWGLA-EFYHPAQEYNVRVASRYFKGPELLVDYQ 223 Query: 178 LYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKL---P 234 +Y S+DMWS GC+ A + P F G D DQL RI ++LGT + + P Sbjct: 224 MYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDP 283 Query: 235 DYKPYPMYPATTSLVNVVPK-----LNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286 + + N + ++ DLL LL+ + QR++A+EA++HPYF Sbjct: 284 HFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 340 >4MD7-E nrPDB Length = 391 Score = 213 bits (544), Expect = 6e-56, Method: Composition-based stats. Identities = 86/297 (28%), Positives = 146/297 (49%), Gaps = 21/297 (7%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH- 60 Y+ + K+G G Y VF+A N +E V + REI +L+ L+ Sbjct: 37 DDYQLVRKLGRGKYSEVFEAINITNNEK-----VVVKILKPVKKKKIKREIKILENLRGG 91 Query: 61 KNIVRLHDVLHSD--KKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCH 118 NI+ L D++ + LVFE + F L ++ +++++LK L +CH Sbjct: 92 PNIITLADIVKDPVSRTPALVFEHVNNT---DFKQLYQTLTDYDIRFYMYEILKALDYCH 148 Query: 119 SRNVLHRDLKPQNLLIN-RNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAK 177 S ++HRD+KP N++I+ + +L+L D+GLA F P + Y+ V + +++ P++L + Sbjct: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLVDYQ 207 Query: 178 LYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKL---P 234 +Y S+DMWS GC+ A + P F G+D DQL RI ++LGT + + P Sbjct: 208 MYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDP 267 Query: 235 DYKPYPMYPATTSLVNVVPK-----LNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286 + + V ++ D L LL+ + R++A EA++HPYF Sbjct: 268 RFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 >4FR4-A nrPDB Length = 384 Score = 213 bits (542), Expect = 9e-56, Method: Composition-based stats. Identities = 64/291 (21%), Positives = 120/291 (41%), Gaps = 32/291 (10%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVP-SSALREICLLKELKH 60 +E L IG+G++G V + +T ++ A+K + E + +E+ +++ L+H Sbjct: 15 DHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQGLEH 74 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 +V L ++ + +V + +Y N E VK F+ +L+ L + ++ Sbjct: 75 PFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELVMALDYLQNQ 134 Query: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAK--L 178 ++HRD+KP N+L++ +G + + DF +A + + T Y P++ K Sbjct: 135 RIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQI-TTMAGTKPYMAPEMFSSRKGAG 193 Query: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKP 238 YS ++D WS G EL RP + Sbjct: 194 YSFAVDWWSLGVTAYELLRGRRPYHIRSSTSS---------------------------K 226 Query: 239 YPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRIS-AEEALQHPYFSD 288 ++ T++V + LL+ LL+ NP QR S + PY +D Sbjct: 227 EIVHTFETTVVTYPSAWSQEMVSLLKKLLEPNPDQRFSQLSDVQNFPYMND 277 >6FYV-A nrPDB Length = 337 Score = 213 bits (542), Expect = 1e-55, Method: Composition-based stats. Identities = 75/327 (22%), Positives = 132/327 (40%), Gaps = 52/327 (15%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRE-THEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 +YE ++ +GEG +G V + + VA+K V+ +A EI +L+ L Sbjct: 15 RYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVG---RYREAARSEIQVLEHLNST 71 Query: 62 N------IVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNG-DLDPEIVKSFLFQLLKGL 114 + V++ + + +VFE + + + ++ +Q+ + + Sbjct: 72 DPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSI 131 Query: 115 GFCHSRNVLHRDLKPQNLLINR-------------------NGELKLADFGLARAFGIPV 155 F H + H DLKP+N+L + N ++K+ DFG A Sbjct: 132 NFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSAT---YDD 188 Query: 156 RCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRI 215 +S V T YR P+V+ +S D+WS GCI E G +F +D + L + Sbjct: 189 EHHSTLVSTRHYRAPEVILAL-GWSQPCDVWSIGCILIE-YYLGFTVFQTHDSKEHLAMM 246 Query: 216 FRLLGTPTEE----------------QWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATG 259 R+LG + W + Y P + + + Sbjct: 247 ERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKP-LKEFMLCHDEEHEKL 305 Query: 260 RDLLQNLLKCNPVQRISAEEALQHPYF 286 DL++ +L+ +P QRI+ +EALQHP+F Sbjct: 306 FDLVRRMLEYDPTQRITLDEALQHPFF 332 >3FME-A nrPDB Length = 290 Score = 213 bits (542), Expect = 1e-55, Method: Composition-based stats. Identities = 71/293 (24%), Positives = 121/293 (41%), Gaps = 35/293 (11%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 E + ++G G YG V K ++ + +I+A+KR+R + + + ++ + Sbjct: 7 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCP 66 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDS---CNGDLDPEIVKSFLFQLLKGLGFCH 118 V + L + + + E D L K++ + +I+ ++K L H Sbjct: 67 FTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLH 126 Query: 119 SR-NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVL---F 174 S+ +V+HRD+KP N+LIN G++K+ DFG++ V + Y P+ + Sbjct: 127 SKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDDV-AKDIDAGCKPYMAPERINPEL 185 Query: 175 GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLP 234 K YS D+WS G ELA P QLK++ Sbjct: 186 NQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVE----------------- 228 Query: 235 DYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFS 287 +P P PA K +A D LK N +R + E +QHP+F+ Sbjct: 229 --EPSPQLPA--------DKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFT 271 >6CKI-A nrPDB Length = 316 Score = 212 bits (540), Expect = 1e-55, Method: Composition-based stats. Identities = 70/304 (23%), Positives = 116/304 (38%), Gaps = 29/304 (9%) Query: 4 YEKLE-KIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELK-HK 61 Y+ E +GEG + V N T + A+K + + + S RE+ +L + + H+ Sbjct: 14 YQLQEDVLGEGAHARVQTCINLITSQEYAVKII--EKQPGHIRSRVFREVEMLYQCQGHR 71 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN 121 N++ L + + + LVFE + + + L F H++ Sbjct: 72 NVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHNKG 131 Query: 122 VLHRDLKPQNLLINRNGE---LKLADFGLARAFGIPVRCYS-------AEVVTLWYRPPD 171 + HRDLKP+N+L + +K+ DFGL + C + Y P+ Sbjct: 132 IAHRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPELLTPCGSAEYMAPE 191 Query: 172 VL----FGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQW 227 V+ A +Y D+WS G I L + G P F G D G E Sbjct: 192 VVEAFSEEASIYDKRCDLWSLGVILYILLS-GYPPFVGRCGSD--------CGWDRGEAC 242 Query: 228 PSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFS 287 P+ + ++ +DL+ LL + QR+SA + LQHP+ Sbjct: 243 PACQNM--LFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQ 300 Query: 288 DFCP 291 P Sbjct: 301 GCAP 304 >3LM0-A nrPDB Length = 327 Score = 212 bits (540), Expect = 1e-55, Method: Composition-based stats. Identities = 71/291 (24%), Positives = 130/291 (44%), Gaps = 38/291 (13%) Query: 8 EKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH-KNIVRL 66 +++G G + V + ++ T + A K ++ + + L EI +L+ K ++ L Sbjct: 35 KELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELAKSCPRVINL 94 Query: 67 HDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDL----DPEIVKSFLFQLLKGLGFCHSRNV 122 H+V + ++ L+ E+ + F C +L V + Q+L+G+ + H N+ Sbjct: 95 HEVYENTSEIILILEYAAGG--EIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQNNI 152 Query: 123 LHRDLKPQNLLINRN---GELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLY 179 +H DLKPQN+L++ G++K+ DFG++R G + T Y P++L Sbjct: 153 VHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACE-LREIMGTPEYLAPEIL-NYDPI 210 Query: 180 STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPY 239 +T+ DMW+ G I L P F G D + I ++ +EE + S+++L Sbjct: 211 TTATDMWNIGIIAYMLLTHTSP-FVGEDNQETYLNISQVNVDYSEETFSSVSQL------ 263 Query: 240 PMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFC 290 D +Q+LL NP +R +AE L H + + Sbjct: 264 -------------------ATDFIQSLLVKNPEKRPTAEICLSHSWLQQWD 295 >4AN9-A nrPDB Length = 301 Score = 212 bits (540), Expect = 2e-55, Method: Composition-based stats. Identities = 69/287 (24%), Positives = 118/287 (41%), Gaps = 33/287 (11%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 +EK+ ++G G G VFK ++ + ++A K + L+ + + +RE+ +L E Sbjct: 9 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE-IKPAIRNQIIRELQVLHECNSP 67 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFC-HSR 120 IV + +SD ++++ E D G + +I+ ++KGL + Sbjct: 68 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKH 127 Query: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYS 180 ++HRD+KP N+L+N GE+KL DFG++ + V T Y P+ L G YS Sbjct: 128 KIMHRDVKPSNILVNSRGEIKLCDFGVSGQLI--DEMANEFVGTRSYMSPERLQGT-HYS 184 Query: 181 TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYP 240 D+WS G E+A P P IF LL E P + Sbjct: 185 VQSDIWSMGLSLVEMAVGRYPRPP--------MAIFELLDYIVNEPPPKLPSA------- 229 Query: 241 MYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFS 287 + +D + L NP +R ++ + H + Sbjct: 230 -------------VFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIK 263 >4TNB-A nrPDB Length = 590 Score = 212 bits (540), Expect = 2e-55, Method: Composition-based stats. Identities = 66/294 (22%), Positives = 120/294 (40%), Gaps = 36/294 (12%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRV-RLDDDDEGVPSSALREICLLKELKHKN 62 + + +G+G +G V + R T ++ A KR+ + S AL E +L+++ + Sbjct: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQF 245 Query: 63 IVRLHDVLHSDKKLTLVFEFCDQDLKKY--FDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 +V L + L LV + K+ ++ N + E + ++L GL H Sbjct: 246 VVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHHE 305 Query: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYS 180 N ++RDLKP+N+L++ G ++++D GLA V T+ Y P+VL + Y Sbjct: 306 NTVYRDLKPENILLDDYGHIRISDLGLAVKIP-EGDLIRGRVGTVGYMAPEVLNNQR-YG 363 Query: 181 TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYP 240 S D W GC+ E+ P F G + + + R + Sbjct: 364 LSPDYWGLGCLIYEMIEGQSP-FRGRKEKVKREEVDRRV--------------------- 401 Query: 241 MYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRIS-----AEEALQHPYFSDF 289 + K + + + + LL + QR+ A E +HP+F + Sbjct: 402 ----LETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEEAAEVKRHPFFRNM 451 >2FO0-A nrPDB Length = 495 Score = 211 bits (537), Expect = 3e-55, Method: Composition-based stats. Identities = 64/285 (22%), Positives = 121/285 (42%), Gaps = 37/285 (12%) Query: 1 MQKYEK--LEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKEL 58 M++ + K+G G YG V++ ++ VA+K ++ D + L+E ++KE+ Sbjct: 214 MERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTME---VEEFLKEAAVMKEI 270 Query: 59 KHKNIVRLHDVLHSDKKLTLVFEFCD-QDLKKYFDSCNG-DLDPEIVKSFLFQLLKGLGF 116 KH N+V+L V + ++ EF +L Y CN +++ ++ Q+ + + Sbjct: 271 KHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEY 330 Query: 117 CHSRNVLHRDLKPQNLLINRNGELKLADFGLARAF-GIPVRCYSAEVVTLWYRPPDVLFG 175 +N +HR+L +N L+ N +K+ADFGL+R G ++ + + P+ L Sbjct: 331 LEKKNFIHRNLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAY 390 Query: 176 AKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPD 235 K +S D+W+ G + E+A G +PG D+ + + + E P Sbjct: 391 NK-FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVY--- 446 Query: 236 YKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEA 280 +L++ + NP R S E Sbjct: 447 -------------------------ELMRACWQWNPSDRPSFAEI 466 >5UUU-A nrPDB Length = 547 Score = 211 bits (537), Expect = 4e-55, Method: Composition-based stats. Identities = 69/299 (23%), Positives = 122/299 (40%), Gaps = 38/299 (12%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSS-ALREICLLKEL- 58 M + IG G +G V+ + +T ++ A+K + + AL E +L + Sbjct: 197 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 256 Query: 59 --KHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGF 116 IV + H+ KL+ + + + Y S +G ++ + +++ GL Sbjct: 257 TGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEH 316 Query: 117 CHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGA 176 H+R V++RDLKP N+L++ +G ++++D GLA F + A V T Y P+VL Sbjct: 317 MHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSK--KKPHASVGTHGYMAPEVLQKG 374 Query: 177 KLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDY 236 Y +S D +S GC+ +L P D I R+ Sbjct: 375 VAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKH--EIDRM------------------ 414 Query: 237 KPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRI-----SAEEALQHPYFSDFC 290 T V + + R LL+ LL+ + +R+ A+E + P+F Sbjct: 415 -------TLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLD 466 >3C51-A nrPDB Length = 543 Score = 211 bits (537), Expect = 4e-55, Method: Composition-based stats. Identities = 66/291 (22%), Positives = 115/291 (39%), Gaps = 37/291 (12%) Query: 8 EKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGV-PSSALREICLLKELKHKNIVRL 66 +G G +G VF + + T ++ A K++ + A+ E +L ++ + IV L Sbjct: 191 RVLGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILAKVHSRFIVSL 250 Query: 67 HDVLHSDKKLTLVFEFCDQDLKKYF----DSCNGDLDPEIVKSFLFQLLKGLGFCHSRNV 122 + L LV + +Y D N + Q++ GL H RN+ Sbjct: 251 AYAFETKTDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQIVSGLEHLHQRNI 310 Query: 123 LHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTS 182 ++RDLKP+N+L++ +G ++++D GLA T + P++L G + Y S Sbjct: 311 IYRDLKPENVLLDDDGNVRISDLGLAVELKAGQTKTKGYAGTPGFMAPELLLGEE-YDFS 369 Query: 183 IDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMY 242 +D ++ G E+ A P R G E + L YP Sbjct: 370 VDYFALGVTLYEMIAARGPF--------------RARGEKVENKELKQRVLEQAVTYP-- 413 Query: 243 PATTSLVNVVPKLNATGRDLLQNLLKCNPVQRI-----SAEEALQHPYFSD 288 K + +D + LL+ +P +R+ S + HP F D Sbjct: 414 ----------DKFSPASKDFCEALLQKDPEKRLGFRDGSCDGLRTHPLFRD 454 >4XEY-B nrPDB Length = 408 Score = 210 bits (536), Expect = 4e-55, Method: Composition-based stats. Identities = 65/285 (22%), Positives = 121/285 (42%), Gaps = 37/285 (12%) Query: 1 MQKYEK--LEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKEL 58 M++ + K+G G YG V++ ++ VA+K ++ D + L+E ++KE+ Sbjct: 122 MERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTME---VEEFLKEAAVMKEI 178 Query: 59 KHKNIVRLHDVLHSDKKLTLVFEFCD-QDLKKYFDSCNG-DLDPEIVKSFLFQLLKGLGF 116 KH N+V+L V + ++ EF +L Y CN +++ ++ Q+ + + Sbjct: 179 KHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEY 238 Query: 117 CHSRNVLHRDLKPQNLLINRNGELKLADFGLARAF-GIPVRCYSAEVVTLWYRPPDVLFG 175 +N +HRDL +N L+ N +K+ADFGL+R G ++ + + P+ L Sbjct: 239 LEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAY 298 Query: 176 AKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPD 235 K +S D+W+ G + E+A G +PG D+ + + + E P Sbjct: 299 NK-FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVY--- 354 Query: 236 YKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEA 280 +L++ + NP R S E Sbjct: 355 -------------------------ELMRACWQWNPSDRPSFAEI 374 >5XVU-A nrPDB Length = 332 Score = 210 bits (536), Expect = 5e-55, Method: Composition-based stats. Identities = 85/299 (28%), Positives = 151/299 (50%), Gaps = 21/299 (7%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH- 60 +YE ++KIG G Y VF + E + A + REI +L+ L Sbjct: 31 NRYEIMKKIGRGKYSEVFNGYDTECNRPCA-----IKVLKPVKKKKIKREIKILQNLNGG 85 Query: 61 KNIVRLHDVLHSD--KKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCH 118 NI++L D++ K +L+FE+ + F + + ++ +++Q+LK L +CH Sbjct: 86 PNIIKLLDIVKDPVTKTPSLIFEYINNI---DFKTLYPKFTDKDIRYYIYQILKALDYCH 142 Query: 119 SRNVLHRDLKPQNLLIN-RNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAK 177 S+ ++HRD+KP N++I+ N +++L +GLA F P + Y+ V + +Y+ P++L + Sbjct: 143 SQGIMHRDVKPHNIMIDHENRQIRLISWGLA-EFYHPGQEYNVRVASRYYKGPELLIDLQ 201 Query: 178 LYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKL---P 234 LY S+D+WS GC+ A + P F G+D DQL +I ++LGT + + P Sbjct: 202 LYDYSLDIWSLGCMLAGMIFKKEPFFCGHDNYDQLVKIAKVLGTEDLHAYLKKYNIKLKP 261 Query: 235 DYKPYPMYPATTSLVNVVPKLN-----ATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288 Y + + + N DL+ +L + +RI+ +EA++HPYF + Sbjct: 262 HYLNILGEYERKPWSHFLTQSNIDIAKDEVIDLIDKMLIYDHAKRIAPKEAMEHPYFRE 320 >3PVW-A nrPDB Length = 695 Score = 210 bits (535), Expect = 6e-55, Method: Composition-based stats. Identities = 69/299 (23%), Positives = 122/299 (40%), Gaps = 38/299 (12%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSS-ALREICLLKEL- 58 M + IG G +G V+ + +T ++ A+K + + AL E +L + Sbjct: 188 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 247 Query: 59 --KHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGF 116 IV + H+ KL+ + + + Y S +G ++ + +++ GL Sbjct: 248 TGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEH 307 Query: 117 CHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGA 176 H+R V++RDLKP N+L++ +G ++++D GLA F + A V T Y P+VL Sbjct: 308 MHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSK--KKPHASVGTHGYMAPEVLQKG 365 Query: 177 KLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDY 236 Y +S D +S GC+ +L P D I R+ Sbjct: 366 VAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKH--EIDRM------------------ 405 Query: 237 KPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRI-----SAEEALQHPYFSDFC 290 T V + + R LL+ LL+ + +R+ A+E + P+F Sbjct: 406 -------TLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLD 457 >3PPZ-A nrPDB Length = 309 Score = 209 bits (533), Expect = 1e-54, Method: Composition-based stats. Identities = 70/295 (23%), Positives = 116/295 (39%), Gaps = 40/295 (13%) Query: 6 KLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVR 65 EKIG G++GTV +A+ VA+K + D + LRE+ ++K L+H NIV Sbjct: 41 IKEKIGAGSFGTVHRAEWH--GSDVAVKILMEQDFHAERVNEFLREVAIMKRLRHPNIVL 98 Query: 66 LHDVLHSDKKLTLVFEFCD-QDLKKYFDSCNGD--LDPEIVKSFLFQLLKGLGFCHSRN- 121 + L++V E+ L + LD S + + KG+ + H+RN Sbjct: 99 FMGAVTQPPNLSIVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAKGMNYLHNRNP 158 Query: 122 -VLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYS 180 ++HRDLK NLL+++ +K+ DFGL+R + T + P+VL + Sbjct: 159 PIVHRDLKSPNLLVDKKYTVKVCDFGLSRLKASTFLSSKSAAGTPEWMAPEVLRDEPS-N 217 Query: 181 TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYP 240 D++S G I ELA +P N F+ Sbjct: 218 EKSDVYSFGVILWELATLQQPWGNLNPAQVVAAVGFKC---------------------- 255 Query: 241 MYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRI---SAEEALQHPYFSDFCPP 292 + + LN +++ P +R + + L+ P PP Sbjct: 256 ------KRLEIPRNLNPQVAAIIEGCWTNEPWKRPSFATIMDLLR-PLIKSAVPP 303 >4WNO-A nrPDB Length = 287 Score = 209 bits (532), Expect = 1e-54, Method: Composition-based stats. Identities = 72/294 (24%), Positives = 124/294 (42%), Gaps = 40/294 (13%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHE-IVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 ++ + + IG G + VFK ++R H+ VA+K + + + +EI +LKELKH+ Sbjct: 19 EFSRKDLIGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQT-LLGKEIKILKELKHE 77 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN 121 NIV L+D + LV E+C+ + L + ++ FL Q+ + HS+ Sbjct: 78 NIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKG 137 Query: 122 VLHRDLKPQNLLINRNG---------ELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDV 172 ++HRDLKPQN+L++ +K+ADFG AR + + + Y P+V Sbjct: 138 IIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMA-ATLCGSPMYMAPEV 196 Query: 173 LFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTK 232 + ++ Y D+WS G I + P F + D L E+ + Sbjct: 197 IM-SQHYDGKADLWSIGTIVYQCLTGKAP-FQASSPQD--------LRLFYEKNKTLVPT 246 Query: 233 LPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286 +P P+ +L+ N R+ +E HP+ Sbjct: 247 IPRETSAPLRQLLLALLQR------------------NHKDRMDFDEFFHHPFL 282 >6CCF-A nrPDB Length = 290 Score = 208 bits (531), Expect = 2e-54, Method: Composition-based stats. Identities = 68/316 (21%), Positives = 122/316 (38%), Gaps = 57/316 (18%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGV---------------- 44 + +Y+ +IG+G YG V A N A+K + + Sbjct: 4 LNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQG 63 Query: 45 --------PSSALREICLLKELKHKNIVRLHDVLHS--DKKLTLVFEFCDQDLKKYFDSC 94 +EI +LK+L H N+V+L +VL + L LVF+ + C Sbjct: 64 GPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEVP-C 122 Query: 95 NGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIP 154 + E + +L ++ GL + H + ++HRD+KP NLL+ +G +K+ADFG++ F Sbjct: 123 DKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGN 182 Query: 155 VRCYSAEVVTLWYRPPDVL--FGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQL 212 S+ T + P+ + G ++D+W+ G P +DD + Sbjct: 183 DAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPF-----IDDFI 237 Query: 213 KRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPV 272 + R + P+++ +DL+ +L NP Sbjct: 238 LALHRKIKNEPVVFPEE-----------------------PEISEELKDLILKMLDKNPE 274 Query: 273 QRISAEEALQHPYFSD 288 RI + HP+ + Sbjct: 275 TRIGVPDIKLHPWVTK 290 >6EII-A nrPDB Length = 352 Score = 208 bits (530), Expect = 2e-54, Method: Composition-based stats. Identities = 86/297 (28%), Positives = 146/297 (49%), Gaps = 21/297 (7%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH- 60 Y+ + K+G G Y VF+A N +E V + REI +L+ L+ Sbjct: 60 DDYQLVRKLGRGKYSEVFEAINITNNEK-----VVVKILKPVKKKKIKREIKILENLRGG 114 Query: 61 KNIVRLHDVLHSD--KKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCH 118 NI+ L D++ + LVFE + F L ++ +++++LK L +CH Sbjct: 115 PNIITLADIVKDPVSRTPALVFEHVNNT---DFKQLYQTLTDYDIRFYMYEILKALDYCH 171 Query: 119 SRNVLHRDLKPQNLLIN-RNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAK 177 S ++HRD+KP N++I+ + +L+L D+GLA F P + Y+ V + +++ P++L + Sbjct: 172 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLVDYQ 230 Query: 178 LYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKL---P 234 +Y S+DMWS GC+ A + P F G+D DQL RI ++LGT + + P Sbjct: 231 MYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDP 290 Query: 235 DYKPYPMYPATTSLVNVVPK-----LNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286 + + V ++ D L LL+ + R++A EA++HPYF Sbjct: 291 RFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 347 >6NPU-A nrPDB Length = 298 Score = 208 bits (529), Expect = 3e-54, Method: Composition-based stats. Identities = 65/285 (22%), Positives = 121/285 (42%), Gaps = 37/285 (12%) Query: 1 MQKYEK--LEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKEL 58 M++ + K+G G YG V++ ++ VA+K ++ D + L+E ++KE+ Sbjct: 23 MERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTME---VEEFLKEAAVMKEI 79 Query: 59 KHKNIVRLHDVLHSDKKLTLVFEFCD-QDLKKYFDSCNG-DLDPEIVKSFLFQLLKGLGF 116 KH N+V+L V + ++ EF +L Y CN +++ ++ Q+ + + Sbjct: 80 KHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEY 139 Query: 117 CHSRNVLHRDLKPQNLLINRNGELKLADFGLARAF-GIPVRCYSAEVVTLWYRPPDVLFG 175 +N +HRDL +N L+ N +K+ADFGL+R G ++ + + P+ L Sbjct: 140 LEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAY 199 Query: 176 AKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPD 235 K +S D+W+ G + E+A G +PG D+ + + + E P Sbjct: 200 NK-FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVY--- 255 Query: 236 YKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEA 280 +L++ + NP R S E Sbjct: 256 -------------------------ELMRACWQWNPSDRPSFAEI 275 >6QAU-A nrPDB Length = 280 Score = 207 bits (528), Expect = 4e-54, Method: Composition-based stats. Identities = 74/296 (25%), Positives = 126/296 (42%), Gaps = 40/296 (13%) Query: 3 KYEKLEKIGEGTYGTVFKAKNR-ETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 +Y K + +G G + VF+ ++R +T VA+K + + + +EI +LKEL+H+ Sbjct: 12 EYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQI-LLGKEIKILKELQHE 70 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN 121 NIV L+DV + LV E+C+ + G L + ++ FL Q+ + HS+ Sbjct: 71 NIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRILHSKG 130 Query: 122 VLHRDLKPQNLLIN---------RNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDV 172 ++HRDLKPQN+L++ +K+ADFG AR + + + Y P+V Sbjct: 131 IIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMA-ADLCGSPMYMAPEV 189 Query: 173 LFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTK 232 + ++ Y D+WS G + + G+P F N D L E+ M Sbjct: 190 IM-SQHYDAKADLWSIGTVIYQCLV-GKPPFQANSPQD--------LRMFYEKNRSLMPS 239 Query: 233 LPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288 +P + L+ + N R+ E HP+ Sbjct: 240 IPRETSPYLANLLLGLL------------------QRNQKDRMDFEAFFSHPFLEQ 277 >2XYN-A nrPDB Length = 292 Score = 207 bits (527), Expect = 4e-54, Method: Composition-based stats. Identities = 64/256 (25%), Positives = 115/256 (44%), Gaps = 19/256 (7%) Query: 1 MQKYEKLE-------KIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREIC 53 M K+E K+G G YG V+ ++ VA+K ++ D + L+E Sbjct: 24 MDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTME---VEEFLKEAA 80 Query: 54 LLKELKHKNIVRLHDVLHSDKKLTLVFEFCD-QDLKKYFDSCNGD-LDPEIVKSFLFQLL 111 ++KE+KH N+V+L V + +V E+ +L Y CN + + ++ Q+ Sbjct: 81 VMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQIS 140 Query: 112 KGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAF-GIPVRCYSAEVVTLWYRPP 170 + + +N +HRDL +N L+ N +K+ADFGL+R G ++ + + P Sbjct: 141 SAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAP 200 Query: 171 DVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGND---VDDQLKRIFRLLGT--PTEE 225 + L +S D+W+ G + E+A G +PG D V D L++ +R+ + Sbjct: 201 ESL-AYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPK 259 Query: 226 QWPSMTKLPDYKPYPM 241 + M + P Sbjct: 260 VYELMRACWKWSPADR 275 >2WO6-A nrPDB Length = 382 Score = 207 bits (527), Expect = 6e-54, Method: Composition-based stats. Identities = 86/334 (25%), Positives = 132/334 (39%), Gaps = 48/334 (14%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 M +YE IG+G++G V KA +R E VA+K ++ +R + L+ + Sbjct: 53 MDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDT 112 Query: 61 K---NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGD-LDPEIVKSFLFQLLKGLGF 116 + IV L L LVFE +L + N + + + F Q+ L F Sbjct: 113 EMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLF 172 Query: 117 CH--SRNVLHRDLKPQNLLI--NRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDV 172 +++H DLKP+N+L+ + +K+ DFG + G + Y + + +YR P+V Sbjct: 173 LATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQY---IQSRFYRSPEV 229 Query: 173 LFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPT-------EE 225 L G Y +IDMWS GCI E+ PLF G + DQ+ +I +LG P + Sbjct: 230 LLGM-PYDLAIDMWSLGCILVEMHTGE-PLFSGANEVDQMNKIVEVLGIPPAHILDQAPK 287 Query: 226 QWPSMTKLPDYKPYPMYPATTSLVNVVPKLNA---------------------------- 257 KLPD P Sbjct: 288 ARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYL 347 Query: 258 TGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCP 291 +DL+ +L +P RI ALQH +F Sbjct: 348 KFKDLILRMLDYDPKTRIQPYYALQHSFFKKTAD 381 >6BXI-A nrPDB Length = 333 Score = 206 bits (525), Expect = 8e-54, Method: Composition-based stats. Identities = 69/326 (21%), Positives = 111/326 (34%), Gaps = 67/326 (20%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALR-EICLLKELK 59 ++ +E L+ IG G +G V + ++T + A+K +R D E +R E +L E Sbjct: 5 LEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEAD 64 Query: 60 HKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 +V++ L L+ EF L E + ++ + + + H Sbjct: 65 SLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQ 124 Query: 120 RNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRC---------------------- 157 +HRD+KP NLL++ G +KL+DFGL R Sbjct: 125 LGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSK 184 Query: 158 -------------YSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFP 204 + V T Y P+V Y+ D WS G I E+ G P F Sbjct: 185 RKAETWKRNRRQLAFSTVGTPDYIAPEVFMQT-GYNKLCDWWSLGVIMYEMLI-GYPPFC 242 Query: 205 GNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQ 264 + K++ W P P ++ +DL+ Sbjct: 243 SETPQETYKKVMN---------WKETLTFPPEVP----------------ISEKAKDLIL 277 Query: 265 NLLKCNPVQRISA---EEALQHPYFS 287 C RI A EE + +F Sbjct: 278 RF-CCEWEHRIGAPGVEEIKSNSFFE 302 >1TKI-A nrPDB Length = 321 Score = 205 bits (523), Expect = 1e-53, Method: Composition-based stats. Identities = 70/290 (24%), Positives = 126/290 (43%), Gaps = 34/290 (11%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 +KY E +G G +G V + + + K V++ D+ + EI +L +H+ Sbjct: 5 EKYMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVKGTDQVLVKK---EISILNIARHR 61 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 NI+ LH+ S ++L ++FEF D+ + ++ +L+ + S++ Q+ + L F HS Sbjct: 62 NILHLHESFESMEELVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCEALQFLHSH 121 Query: 121 NVLHRDLKPQNLLIN--RNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL 178 N+ H D++P+N++ R+ +K+ +FG AR P + Y P+V + Sbjct: 122 NIGHFDIRPENIIYQTRRSSTIKIIEFGQARQL-KPGDNFRLLFTAPEYYAPEV-HQHDV 179 Query: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKP 238 ST+ DMWS G + L + P ++ I T EE + Sbjct: 180 VSTATDMWSLGTLVYVLLSGINPFLA-ETNQQIIENIMNAEYTFDEEAFK---------- 228 Query: 239 YPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288 +++ D + LL R++A EALQHP+ Sbjct: 229 ---------------EISIEAMDFVDRLLVKERKSRMTASEALQHPWLKQ 263 >5O2C-A nrPDB Length = 380 Score = 205 bits (521), Expect = 2e-53, Method: Composition-based stats. Identities = 64/293 (21%), Positives = 124/293 (42%), Gaps = 40/293 (13%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62 K++ ++G G + TV+K + ET VA ++ + E +LK L+H N Sbjct: 28 KFDI--ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPN 85 Query: 63 IVRLHDVLHS----DKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCH 118 IVR +D S K + LV E K + + P++++S+ Q+LKGL F H Sbjct: 86 IVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLH 145 Query: 119 SRN--VLHRDLKPQNLLIN-RNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFG 175 +R ++HRDLK N+ I G +K+ D GLA + + T + P++ Sbjct: 146 TRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLM--RTSFAKSVIGTPEFMAPEMYE- 202 Query: 176 AKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPD 235 + Y S+D+++ G E+A + P + +++ + Sbjct: 203 -EHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKP-------------- 247 Query: 236 YKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288 + + +++++ ++ N +R+S + L H +F++ Sbjct: 248 -------------ASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAE 287 >5O2B-A nrPDB Length = 285 Score = 205 bits (521), Expect = 3e-53, Method: Composition-based stats. Identities = 64/293 (21%), Positives = 124/293 (42%), Gaps = 40/293 (13%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62 K++ ++G G + TV+K + ET VA ++ + E +LK L+H N Sbjct: 19 KFDI--ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPN 76 Query: 63 IVRLHDVLHS----DKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCH 118 IVR +D S K + LV E K + + P++++S+ Q+LKGL F H Sbjct: 77 IVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLH 136 Query: 119 SRN--VLHRDLKPQNLLIN-RNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFG 175 +R ++HRDLK N+ I G +K+ D GLA + + T + P++ Sbjct: 137 TRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLM--RTSFAKSVIGTPEFMAPEMYE- 193 Query: 176 AKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPD 235 + Y S+D+++ G E+A + P + +++ + Sbjct: 194 -EHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKP-------------- 238 Query: 236 YKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288 + + +++++ ++ N +R+S + L H +F++ Sbjct: 239 -------------ASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAE 278 >4E93-A nrPDB Length = 377 Score = 205 bits (521), Expect = 3e-53, Method: Composition-based stats. Identities = 62/246 (25%), Positives = 106/246 (43%), Gaps = 12/246 (4%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 + E+IG G +G VF + R + +VA+K R + + + L+E +LK+ H Sbjct: 114 EDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCR-ETLPPDLKAKFLQEARILKQYSHP 172 Query: 62 NIVRLHDVLHSDKKLTLVFEFC-DQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 NIVRL V + + +V E D + + L + + + G+ + S+ Sbjct: 173 NIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESK 232 Query: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSA---EVVTLWYRPPDVLFGAK 177 +HRDL +N L+ LK++DFG++R V S +V W P+ L + Sbjct: 233 CCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWT-APEALNYGR 291 Query: 178 LYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPS-----MTK 232 YS+ D+WS G + E + G +P + + + P E P M + Sbjct: 292 -YSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQ 350 Query: 233 LPDYKP 238 Y+P Sbjct: 351 CWAYEP 356 >5H2U-A nrPDB Length = 267 Score = 205 bits (521), Expect = 3e-53, Method: Composition-based stats. Identities = 63/267 (23%), Positives = 114/267 (42%), Gaps = 16/267 (5%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 +++ K+G G +G VF+ ++ VA+K + D+ EI +K+L+HK Sbjct: 6 EEFTLCRKLGSGYFGEVFEGLWKD-RVQVAIKVISRDNL--LHQQMLQSEIQAMKKLRHK 62 Query: 62 NIVRLHDVLHSDKKLTLVFEFC-DQDLKKYFD-SCNGDLDPEIVKSFLFQLLKGLGFCHS 119 +I+ L+ V+ + ++ E L + S L + +Q+ +G+ + S Sbjct: 63 HILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLES 122 Query: 120 RNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLY 179 +N +HRDL +N+L+ N K+ DFGLAR V + + P+ L Y Sbjct: 123 QNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEAL-SRGHY 181 Query: 180 STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPY 239 ST D+WS G + E+ + G+ +PG + R+ P P P Sbjct: 182 STKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMP----------CPLECPP 231 Query: 240 PMYPATTSLVNVVPKLNATGRDLLQNL 266 ++ + P+ T + L + L Sbjct: 232 SVHKLMLTCWCRDPEQRPTFKALRERL 258 >3FXW-A nrPDB Length = 336 Score = 204 bits (519), Expect = 5e-53, Method: Composition-based stats. Identities = 65/298 (21%), Positives = 110/298 (36%), Gaps = 43/298 (14%) Query: 2 QKYEK-LEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLL-KELK 59 Y+ + +G G G V + +R T + ALK + A +E+ + Sbjct: 28 DDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLL-------YDSPKARQEVDHHWQASG 80 Query: 60 HKNIVRLHDVLHS----DKKLTLVFEFCDQD-LKKYFDSCNGD-LDPEIVKSFLFQLLKG 113 +IV + DV + + L ++ E + L + + Sbjct: 81 GPHIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTA 140 Query: 114 LGFCHSRNVLHRDLKPQNLLIN---RNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPP 170 + F HS N+ HRD+KP+NLL ++ LKL DFG A+ T +Y P Sbjct: 141 IQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKE--TTQNALQTPCYTPYYVAP 198 Query: 171 DVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSM 230 +VL G + Y S DMWS G I L P + G Sbjct: 199 EVL-GPEKYDKSCDMWSLGVIMYILLCGFPPFYSNT-------------GQAISPGMKRR 244 Query: 231 TKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288 +L Y +++ + L++ LLK +P +R++ + + HP+ + Sbjct: 245 IRLGQYGFPNP---------EWSEVSEDAKQLIRLLLKTDPTERLTITQFMNHPWINQ 293 >2H8H-A nrPDB Length = 535 Score = 203 bits (518), Expect = 5e-53, Method: Composition-based stats. Identities = 68/290 (23%), Positives = 122/290 (42%), Gaps = 43/290 (14%) Query: 9 KIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHD 68 K+G+G +G V+ T VA+K ++ P + L+E ++K+L+H+ +V+L+ Sbjct: 274 KLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMS---PEAFLQEAQVMKKLRHEKLVQLYA 329 Query: 69 VLHSDKKLTLVFEFCD-QDLKKYFDSCNGD-LDPEIVKSFLFQLLKGLGFCHSRNVLHRD 126 V+ S++ + +V E+ L + G L + Q+ G+ + N +HRD Sbjct: 330 VV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRD 388 Query: 127 LKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLW---YRPPDVLFGAKLYSTSI 183 L+ N+L+ N K+ADFGLAR Y+A + + P+ + ++ Sbjct: 389 LRAANILVGENLVCKVADFGLARLI--EDNEYTARQGAKFPIKWTAPEAALYGR-FTIKS 445 Query: 184 DMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYP 243 D+WS G + EL GR +PG + L ++ R P + P Sbjct: 446 DVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECP--------------- 490 Query: 244 ATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAE--EALQHPYFSDFCP 291 + DL+ + P +R + E +A YF+ P Sbjct: 491 -------------ESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEP 527 >5UNP-A nrPDB Length = 369 Score = 203 bits (517), Expect = 6e-53, Method: Composition-based stats. Identities = 85/336 (25%), Positives = 139/336 (41%), Gaps = 54/336 (16%) Query: 2 QKYEKLEKIGEGTYGTVFKAK-NRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 ++YE + +GEGT+G V + +R VALK ++ + E +A EI +L+++ Sbjct: 34 ERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIK---NVEKYKEAARLEINVLEKINE 90 Query: 61 KN------IVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNG-DLDPEIVKSFLFQLLKG 113 K+ V++ D + + FE + N V+ FQL + Sbjct: 91 KDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQA 150 Query: 114 LGFCHSRNVLHRDLKPQNLL-INRNGE------------------LKLADFGLARAFGIP 154 + F H + H DLKP+N+L +N + E +++ DFG A Sbjct: 151 VKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSAT---FD 207 Query: 155 VRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKR 214 +S V T YR P+V+ +S D+WS GCI E G LF +D + L Sbjct: 208 HEHHSTIVSTRHYRAPEVILEL-GWSQPCDVWSIGCIIFE-YYVGFTLFQTHDNREHLAM 265 Query: 215 IFRLLGTPTEE----------------QWPSMTKLPDYKPYPMYPATTSLVNVVPKLNAT 258 + R+LG W T Y P L + + + Sbjct: 266 MERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQL 325 Query: 259 GRDLLQNLLKCNPVQRISAEEALQHPYFSDFC--PP 292 DL++++L+ P +R++ EALQHP+F+ PP Sbjct: 326 F-DLIESMLEYEPAKRLTLGEALQHPFFARLRAEPP 360 >6GVJ-A nrPDB Length = 429 Score = 203 bits (517), Expect = 7e-53, Method: Composition-based stats. Identities = 83/303 (27%), Positives = 132/303 (43%), Gaps = 44/303 (14%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELK-HKN 62 Y L++IG G VF+ N E +I A+K V L++ D S EI L +L+ H + Sbjct: 146 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 204 Query: 63 -IVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN 121 I+RL+D +D+ + +V E + DL + +DP KS+ +L+ + H Sbjct: 205 KIIRLYDYEITDQYIYMVMECGNIDLNSWLKK-KKSIDPWERKSYWKNMLEAVHTIHQHG 263 Query: 122 VLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRC--YSAEVVTLWYRPPDVLFGAK-- 177 ++H DLKP N LI +G LKL DFG+A ++V T+ Y PP+ + Sbjct: 264 IVHSDLKPANFLIV-DGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSS 322 Query: 178 --------LYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPS 229 S D+WS GCI + P + +Q+ ++ ++ E ++P Sbjct: 323 RENGKSKSKISPKSDVWSLGCILYYMTYGKTPF---QQIINQISKLHAIIDPNHEIEFPD 379 Query: 230 MTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDF 289 + + +D+L+ LK +P QRIS E L HPY Sbjct: 380 IPE------------------------KDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQ 415 Query: 290 CPP 292 P Sbjct: 416 THP 418 >4P5Q-A nrPDB Length = 361 Score = 202 bits (515), Expect = 1e-52, Method: Composition-based stats. Identities = 56/273 (20%), Positives = 107/273 (39%), Gaps = 21/273 (7%) Query: 8 EKIGEGTYGTVFKAKNRETHEI---VALKRVRLDDDDEGVPSSALREICLLKELKHKNIV 64 + +G G +G V + + + VA+K +++ E L E ++ + H NI+ Sbjct: 39 KVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVG-YTEKQRRDFLGEASIMGQFDHPNII 97 Query: 65 RLHDVLHSDKKLTLVFEFCD-QDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVL 123 RL V+ K + +V E+ + L + + + L + G+ + + Sbjct: 98 RLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYLSDMGYV 157 Query: 124 HRDLKPQNLLINRNGELKLADFGLARAF-GIPVRCYSAEVV--TLWYRPPDVLFGAKLYS 180 HRDL +N+LIN N K++DFGL+R P Y+ + + P+ + K ++ Sbjct: 158 HRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIAYRK-FT 216 Query: 181 TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYP 240 ++ D+WS G + E+ + G + D +K + P P+ Sbjct: 217 SASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCPA----------A 266 Query: 241 MYPATTSLVNVVPKLNATGRDLLQNL--LKCNP 271 +Y ++ L L NP Sbjct: 267 LYQLMLDCWQKDRNNRPKFEQIVSILDKLIRNP 299 >1S9I-A nrPDB Length = 354 Score = 201 bits (513), Expect = 2e-52, Method: Composition-based stats. Identities = 72/307 (23%), Positives = 126/307 (41%), Gaps = 27/307 (8%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 +E++ ++G G G V K ++R + I+A K + L+ + + +RE+ +L E Sbjct: 16 DDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLE-IKPAIRNQIIRELQVLHECNSP 74 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN 121 IV + +SD ++++ E D + EI+ +L+GL + ++ Sbjct: 75 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREKH 134 Query: 122 -VLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYS 180 ++HRD+KP N+L+N GE+KL DFG++ + ++ V T Y P+ L G YS Sbjct: 135 QIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA--NSFVGTRSYMAPERLQGT-HYS 191 Query: 181 TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKL------- 233 D+WS G ELA P+ P + + L+ IF EE P Sbjct: 192 VQSDIWSMGLSLVELAVGRYPIPPPDAKE--LEAIFGRPVVDGEEGEPHSISPRPRPPGR 249 Query: 234 ------PDYKPYPMYPATTSLVNVVPK-------LNATGRDLLQNLLKCNPVQRISAEEA 280 D +P + P ++ + L NP +R + Sbjct: 250 PVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADLKML 309 Query: 281 LQHPYFS 287 H + Sbjct: 310 TNHTFIK 316 >2XNP-A nrPDB Length = 279 Score = 201 bits (513), Expect = 2e-52, Method: Composition-based stats. Identities = 79/296 (26%), Positives = 120/296 (40%), Gaps = 41/296 (13%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 + YE L IG G+YG K + + +I+ K + E + E+ LL+ELKH Sbjct: 6 EDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHP 65 Query: 62 NIVRLHDVL--HSDKKLTLVFEFCDQ-DLKKYFDSCNGD---LDPEIVKSFLFQLLKGLG 115 NIVR +D + ++ L +V E+C+ DL + LD E V + QL L Sbjct: 66 NIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALK 125 Query: 116 FCHSRN-----VLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPP 170 CH R+ VLHRDLKP N+ ++ +KL DFGLAR V T +Y P Sbjct: 126 ECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSP 185 Query: 171 DVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSM 230 + + Y+ D+WS GC+ EL P F + +I Sbjct: 186 EQM-NRMSYNEKSDIWSLGCLLYELCAL-MPPFTAFSQKELAGKIREG------------ 231 Query: 231 TKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286 + + + +++ +L R S EE L++P Sbjct: 232 ----------------KFRRIPYRYSDELNEIITRMLNLKDYHRPSVEEILENPLI 271 >5B2L-A nrPDB Length = 324 Score = 201 bits (511), Expect = 3e-52, Method: Composition-based stats. Identities = 55/294 (18%), Positives = 111/294 (37%), Gaps = 32/294 (10%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 + E L ++G GT G V+K + R+T ++A+K++R + E + +LK Sbjct: 16 INDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDC 75 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFC-HS 119 IV+ ++ + + E +K G + I+ ++K L + Sbjct: 76 PYIVQCFGTFITNTDVFIAMELMGTSAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEK 135 Query: 120 RNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLF----G 175 V+HRD+KP N+L++ G++KL DFG++ + + + Y P+ + Sbjct: 136 HGVIHRDVKPSNILLDERGQIKLCDFGISGRL-VDSKAKTRSAGCAAYMAPERIDPPDPT 194 Query: 176 AKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPD 235 Y D+WS G ELA P + L ++ + Sbjct: 195 KPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQ------------------ 236 Query: 236 YKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDF 289 L+ + + +++ L + +R + L+H + + Sbjct: 237 --------EEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRY 282 >5MJB-A nrPDB Length = 305 Score = 201 bits (511), Expect = 3e-52, Method: Composition-based stats. Identities = 53/234 (22%), Positives = 105/234 (44%), Gaps = 11/234 (4%) Query: 5 EKLEKIGEGTYGTVFKAKNRETHE---IVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 + E IG G +G V+K + + + VA+K ++ E L E ++ + H+ Sbjct: 29 KIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAG-YSEKQRRDFLSEASIMGQFDHR 87 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 NI+RL V+ + + ++ EF + L + +G + L + G+ + Sbjct: 88 NIIRLEGVVTKSRPVMIITEFMENCALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLSEM 147 Query: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVR--CYSAEVV---TLWYRPPDVLFG 175 N +HRDL +N+L+N N K++DFGL+R Y++ + + + P+ + Sbjct: 148 NYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIAY 207 Query: 176 AKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPS 229 K ++++ D+WS G + E+ + G + D + I + P P+ Sbjct: 208 RK-FTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPA 260 >5L6P-A nrPDB Length = 298 Score = 201 bits (511), Expect = 4e-52, Method: Composition-based stats. Identities = 56/279 (20%), Positives = 113/279 (40%), Gaps = 23/279 (8%) Query: 5 EKLEKIGEGTYGTVFKAKNRETHEI---VALKRVRLDDDDEGVPSSALREICLLKELKHK 61 + E IG G +G V + + ++ VA+K +++ E L E ++ + H Sbjct: 22 KIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVG-YTERQRRDFLSEASIMGQFDHP 80 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 NI+RL V+ + + ++ EF + L + +G + L + G+ + Sbjct: 81 NIIRLEGVVTKSRPVMILTEFMENCALDSFLRLNDGQFTVIQLVGMLRGIAAGMKYLSEM 140 Query: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAFGIP--VRCYSAEVV---TLWYRPPDVLFG 175 N +HRDL +N+L+N N K++DFGL+R Y++ + + + P+ + Sbjct: 141 NYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTAPEAIAY 200 Query: 176 AKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPD 235 K ++++ D+WS G + E+ + G + D + + + P P+ Sbjct: 201 RK-FTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVEQDYRLPPPMDCPT------ 253 Query: 236 YKPYPMYPATTSLVNVVPKLNATGRDLLQNL--LKCNPV 272 ++ L ++ L L NP Sbjct: 254 ----ALHQLMLDCWVRDRNLRPKFSQIVNTLDKLIRNPA 288 >4PWN-A nrPDB Length = 274 Score = 201 bits (511), Expect = 4e-52, Method: Composition-based stats. Identities = 65/293 (22%), Positives = 124/293 (42%), Gaps = 39/293 (13%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62 K++ +IG G++ TV+K + ET VA ++ + E +LK L+H N Sbjct: 13 KFDI--EIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQHPN 70 Query: 63 IVRLHDVLHS----DKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCH 118 IVR +D S K + LV E K + + ++++S+ Q+LKGL F H Sbjct: 71 IVRFYDSWESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKGLQFLH 130 Query: 119 SRN--VLHRDLKPQNLLIN-RNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFG 175 +R ++HRDLK N+ I G +K+ D GLA + + T + P++ Sbjct: 131 TRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLAT-LEKRASFAKSVIGTPEFMAPEMYE- 188 Query: 176 AKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPD 235 + Y S+D+++ G E+A + P + +R+ + + ++ Sbjct: 189 -EKYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPASFDKVAI------ 241 Query: 236 YKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288 +++++ ++ N +R S ++ L H +F + Sbjct: 242 ---------------------PEVKEIIEGCIRQNKDERYSIKDLLNHAFFQE 273 >4AT3-A nrPDB Length = 299 Score = 201 bits (511), Expect = 4e-52, Method: Composition-based stats. Identities = 63/285 (22%), Positives = 124/285 (43%), Gaps = 30/285 (10%) Query: 6 KLEKIGEGTYGTVFKAKN-----RETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 ++GEG +G VF A+ + +VA+K ++ D + RE LL L+H Sbjct: 17 LKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLK--DASDNARKDFHREAELLTNLQH 74 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCD-QDLKKYFDSCNG------------DLDPEIVKSFL 107 ++IV+ + V L +VFE+ DL K+ + +L + Sbjct: 75 EHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIA 134 Query: 108 FQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPV--RCYSAEVVTL 165 Q+ G+ + S++ +HRDL +N L+ N +K+ DFG++R R ++ + Sbjct: 135 QQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPI 194 Query: 166 WYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLK-----RIFRLLG 220 + PP+ + K ++T D+WS G + E+ G+ + ++ ++ R+ + Sbjct: 195 RWMPPESIMYRK-FTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPR 253 Query: 221 TPTEEQWPSMTKLPDYKPY--PMYPATTSLVNVVPKLNATGRDLL 263 T +E + M +P+ +L+ + K + D+L Sbjct: 254 TCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDIL 298 >1NY3-A nrPDB Length = 400 Score = 200 bits (510), Expect = 5e-52, Method: Composition-based stats. Identities = 74/297 (24%), Positives = 120/297 (40%), Gaps = 42/297 (14%) Query: 1 MQKYEKL-EKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLL-KEL 58 + Y+ + +G G G V + N+ T E ALK ++ A RE+ L + Sbjct: 60 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ-------DCPKARREVELHWRAS 112 Query: 59 KHKNIVRLHDVLHS----DKKLTLVFEFCDQDLK--KYFDSCNGDLDPEIVKSFLFQLLK 112 + +IVR+ DV + K L +V E D + D + + + + Sbjct: 113 QCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGE 172 Query: 113 GLGFCHSRNVLHRDLKPQNLLINR---NGELKLADFGLARAFGIPVRCYSAEVVTLWYRP 169 + + HS N+ HRD+KP+NLL N LKL DFG A+ + T +Y Sbjct: 173 AIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKE-TTSHNSLTTPCYTPYYVA 231 Query: 170 PDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPS 229 P+VL G + Y S DMWS G I L P + + G + Sbjct: 232 PEVL-GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNH-------------GLAISPGMKT 277 Query: 230 MTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286 ++ Y+ +++ + L++NLLK P QR++ E + HP+ Sbjct: 278 RIRMGQYEFPNP---------EWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 325 >2WTK-C nrPDB Length = 305 Score = 200 bits (510), Expect = 5e-52, Method: Composition-based stats. Identities = 75/301 (24%), Positives = 137/301 (45%), Gaps = 40/301 (13%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRET--HEIVALKRVRLDDDDEGVPSSALREICLLKEL 58 + KY + +GEG+YG V + + ET V + + + ++ +EI LL+ L Sbjct: 4 IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRL 63 Query: 59 KHKNIVRLHDVL--HSDKKLTLVFEFCDQDLKKYFDSC-NGDLDPEIVKSFLFQLLKGLG 115 +HKN+++L DVL +K+ +V E+C +++ DS + QL+ GL Sbjct: 64 RHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLIDGLE 123 Query: 116 FCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFG---IPVRCYSAEVVTLWYRPPDV 172 + HS+ ++H+D+KP NLL+ G LK++ G+A A C +++ + ++PP++ Sbjct: 124 YLHSQGIVHKDIKPGNLLLTTGGTLKISALGVAEALHPFAADDTCRTSQ-GSPAFQPPEI 182 Query: 173 LFGAKLYS-TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMT 231 G +S +D+WSAG + P F G+++ + I + + P ++ Sbjct: 183 ANGLDTFSGFKVDIWSAGVTLYNITTGLYP-FEGDNIYKLFENIGKGSYAIPGDCGPPLS 241 Query: 232 KLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCP 291 DLL+ +L+ P +R S + QH +F P Sbjct: 242 -----------------------------DLLKGMLEYEPAKRFSIRQIRQHSWFRKKHP 272 Query: 292 P 292 P Sbjct: 273 P 273 >6F3F-A nrPDB Length = 455 Score = 200 bits (510), Expect = 5e-52, Method: Composition-based stats. Identities = 68/290 (23%), Positives = 123/290 (42%), Gaps = 43/290 (14%) Query: 9 KIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHD 68 K+G+G +G V+ T VA+K ++ P + L+E ++K+L+H+ +V+L+ Sbjct: 194 KLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMS---PEAFLQEAQVMKKLRHEKLVQLYA 249 Query: 69 VLHSDKKLTLVFEFCD-QDLKKYFDSCNGD-LDPEIVKSFLFQLLKGLGFCHSRNVLHRD 126 V+ S++ + +V E+ + L + G L + Q+ G+ + N +HRD Sbjct: 250 VV-SEEPIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVERMNYVHRD 308 Query: 127 LKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLW---YRPPDVLFGAKLYSTSI 183 L+ N+L+ N K+ADFGLAR Y+A + + P+ + ++ Sbjct: 309 LRAANILVGENLVCKVADFGLARLI--EDNEYTARQGAKFPIKWTAPEAALYGR-FTIKS 365 Query: 184 DMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYP 243 D+WS G + EL GR +PG + L ++ R P + P Sbjct: 366 DVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECP--------------- 410 Query: 244 ATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAE--EALQHPYFSDFCP 291 + DL+ + P +R + E +A YF+ P Sbjct: 411 -------------ESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEP 447 >3DKO-A nrPDB Length = 318 Score = 200 bits (509), Expect = 6e-52, Method: Composition-based stats. Identities = 55/275 (20%), Positives = 105/275 (38%), Gaps = 17/275 (6%) Query: 5 EKLEKIGEGTYGTVFKAKNRETHEI---VALKRVRLDDDDEGVPSSALREICLLKELKHK 61 + IG G +G V + + + VA+K +++ E L E ++ + H Sbjct: 46 KIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVG-YTEKQRRDFLCEASIMGQFDHP 104 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQD-LKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 N+V L V+ K + +V EF + L + +G + L + G+ + Sbjct: 105 NVVHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGMRYLADM 164 Query: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVV---TLWYRPPDVLFGAK 177 +HRDL +N+L+N N K++DFGL+R + + P+ + K Sbjct: 165 GYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRK 224 Query: 178 LYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYK 237 ++++ D+WS G + E+ + G + D +K I P P+ Sbjct: 225 -FTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPAPMDCPAGLHQLMLD 283 Query: 238 PYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPV 272 + A + + L ++ NP Sbjct: 284 CWQKERAERPKFEQIVGI-------LDKMI-RNPN 310 >2DQ7-X nrPDB Length = 283 Score = 200 bits (508), Expect = 8e-52, Method: Composition-based stats. Identities = 64/294 (21%), Positives = 124/294 (42%), Gaps = 43/294 (14%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 + + ++++G G +G V+ + VA+K ++ P S L E ++K+LKH Sbjct: 9 ESLQLIKRLGNGQFGEVWMGTW-NGNTKVAIKTLKPGTMS---PESFLEEAQIMKKLKHD 64 Query: 62 NIVRLHDVLHSDKKLTLVFEFCD-QDLKKYFDSCNGD-LDPEIVKSFLFQLLKGLGFCHS 119 +V+L+ V+ S++ + +V E+ + L + G L + Q+ G+ + Sbjct: 65 KLVQLYAVV-SEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIER 123 Query: 120 RNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLW---YRPPDVLFGA 176 N +HRDL+ N+L+ K+ADFGLAR Y+A + + P+ Sbjct: 124 MNYIHRDLRSANILVGNGLICKIADFGLARLI--EDNEYTARQGAKFPIKWTAPEAALYG 181 Query: 177 KLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDY 236 + ++ D+WS G + EL GR +PG + + L+++ R P + P Sbjct: 182 R-FTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPI------- 233 Query: 237 KPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFC 290 + +L+ + K +P +R + E + D+ Sbjct: 234 ---------------------SLHELMIHCWKKDPEERPTFEYLQS--FLEDYF 264 >3RAW-A nrPDB Length = 381 Score = 200 bits (508), Expect = 8e-52, Method: Composition-based stats. Identities = 81/333 (24%), Positives = 139/333 (41%), Gaps = 52/333 (15%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHE-IVALKRVRLDDDDEGVPSSALREICLLKELKH 60 ++YE + +GEGT+G V + + + VALK +R +A EI +LK++K Sbjct: 51 ERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVG---KYREAARLEINVLKKIKE 107 Query: 61 KN------IVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCN-GDLDPEIVKSFLFQLLKG 113 K+ V + D + + + FE ++ ++ N V+ +QL Sbjct: 108 KDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHA 167 Query: 114 LGFCHSRNVLHRDLKPQNLLIN-------------------RNGELKLADFGLARAFGIP 154 L F H + H DLKP+N+L +N +++ADFG A Sbjct: 168 LRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSAT---FD 224 Query: 155 VRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKR 214 ++ V T YRPP+V+ ++ D+WS GCI E G LF ++ + L Sbjct: 225 HEHHTTIVATRHYRPPEVILEL-GWAQPCDVWSIGCILFE-YYRGFTLFQTHENREHLVM 282 Query: 215 IFRLLGTPTEE----------------QWPSMTKLPDYKPYPMYPATTSLVNVVPKLNAT 258 + ++LG W + Y P + ++ + + Sbjct: 283 MEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLE-HVQ 341 Query: 259 GRDLLQNLLKCNPVQRISAEEALQHPYFSDFCP 291 DL++ +L+ +P QRI+ EAL HP+F+ P Sbjct: 342 LFDLMRRMLEFDPAQRITLAEALLHPFFAGLTP 374 >3QGY-A nrPDB Length = 286 Score = 200 bits (508), Expect = 8e-52, Method: Composition-based stats. Identities = 58/268 (21%), Positives = 107/268 (39%), Gaps = 21/268 (7%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62 + +++IG G +G V + VA+K ++ E + E ++ +L H Sbjct: 28 ELTFVQEIGSGQFGLVHLGYWLNKDK-VAIKTIKEGSMSED---DFIEEAEVMMKLSHPK 83 Query: 63 IVRLHDVLHSDKKLTLVFEFCDQD-LKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN 121 +V+L+ V + LVFEF + L Y + G E + + +G+ + Sbjct: 84 LVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEAC 143 Query: 122 VLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLW---YRPPDVLFGAKL 178 V+HRDL +N L+ N +K++DFG+ R Y++ T + + P+V F Sbjct: 144 VIHRDLAARNCLVGENQVIKVSDFGMTRFVLDD--QYTSSTGTKFPVKWASPEV-FSFSR 200 Query: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKP 238 YS+ D+WS G + E+ + G+ + + ++ I P Sbjct: 201 YSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDI----------STGFRLYKPRLAS 250 Query: 239 YPMYPATTSLVNVVPKLNATGRDLLQNL 266 +Y P+ LL+ L Sbjct: 251 THVYQIMNHCWKERPEDRPAFSRLLRQL 278 >4XI2-A nrPDB Length = 446 Score = 200 bits (508), Expect = 9e-52, Method: Composition-based stats. Identities = 59/272 (21%), Positives = 117/272 (43%), Gaps = 21/272 (7%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 + L+++G G +G V K R ++ VA+K +R E + E ++ L H+ Sbjct: 187 KDLTFLKELGTGQFGVVKYGKWRGQYD-VAIKMIREGSMSED---EFIEEAKVMMNLSHE 242 Query: 62 NIVRLHDVLHSDKKLTLVFEFC-DQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 +V+L+ V + + ++ E+ + L Y + + + + + + S+ Sbjct: 243 KLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESK 302 Query: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTL---WYRPPDVLFGAK 177 LHRDL +N L+N G +K++DFGL+R Y++ V + + PP+VL +K Sbjct: 303 QFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDD--EYTSSVGSKFPVRWSPPEVLMYSK 360 Query: 178 LYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYK 237 +S+ D+W+ G + E+ + G+ + + + I + L P Sbjct: 361 -FSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYR----------PHLA 409 Query: 238 PYPMYPATTSLVNVVPKLNATGRDLLQNLLKC 269 +Y S + + + LL N+L Sbjct: 410 SERVYTIMYSCWHEKADERPSFKILLSNILDV 441 >2OZA-A nrPDB Length = 356 Score = 199 bits (507), Expect = 1e-51, Method: Composition-based stats. Identities = 74/297 (24%), Positives = 120/297 (40%), Gaps = 42/297 (14%) Query: 1 MQKYEKL-EKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLL-KEL 58 + Y+ + +G G G V + N+ T E ALK ++ A RE+ L + Sbjct: 16 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ-------DCPKARREVELHWRAS 68 Query: 59 KHKNIVRLHDVLHS----DKKLTLVFEFCDQDLK--KYFDSCNGDLDPEIVKSFLFQLLK 112 + +IVR+ DV + K L +V E D + D + + + + Sbjct: 69 QCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGE 128 Query: 113 GLGFCHSRNVLHRDLKPQNLLINR---NGELKLADFGLARAFGIPVRCYSAEVVTLWYRP 169 + + HS N+ HRD+KP+NLL N LKL DFG A+ + T +Y Sbjct: 129 AIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKE-TTSHNSLTTPCYTPYYVA 187 Query: 170 PDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPS 229 P+VL G + Y S DMWS G I L P + + G + Sbjct: 188 PEVL-GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNH-------------GLAISPGMKT 233 Query: 230 MTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286 ++ Y+ +++ + L++NLLK P QR++ E + HP+ Sbjct: 234 RIRMGQYEFPNP---------EWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 281 >2R2P-A nrPDB Length = 295 Score = 199 bits (507), Expect = 1e-51, Method: Composition-based stats. Identities = 56/277 (20%), Positives = 108/277 (38%), Gaps = 21/277 (7%) Query: 5 EKLEKIGEGTYGTVFKAKNRETHEI---VALKRVRLDDDDEGVPSSALREICLLKELKHK 61 IG G +G V + + + VA+K +++ E L E ++ + H Sbjct: 25 TIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVG-YTEKQRRDFLGEASIMGQFDHP 83 Query: 62 NIVRLHDVLHSDKKLTLVFEFCD-QDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 NI+ L V+ K + +V E+ + L + +G + L + G+ + Sbjct: 84 NIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGISAGMKYLSDM 143 Query: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAF-GIPVRCYSAEVV--TLWYRPPDVLFGAK 177 +HRDL +N+LIN N K++DFGL+R P Y+ + + P+ + + Sbjct: 144 GYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAI-AFR 202 Query: 178 LYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYK 237 ++++ D+WS G + E+ + G + D +K + P+ P+ Sbjct: 203 KFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPA-------- 254 Query: 238 PYPMYPATTSLVNVVPKLNATGRDLLQNL--LKCNPV 272 +Y +++ L L NP Sbjct: 255 --ALYQLMLDCWQKERNSRPKFDEIVNMLDKLIRNPA 289 >3KA0-A nrPDB Length = 320 Score = 199 bits (507), Expect = 1e-51, Method: Composition-based stats. Identities = 74/297 (24%), Positives = 120/297 (40%), Gaps = 42/297 (14%) Query: 1 MQKYEKL-EKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLL-KEL 58 + Y+ + +G G G V + N+ T E ALK ++ A RE+ L + Sbjct: 14 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ-------DCPKARREVELHWRAS 66 Query: 59 KHKNIVRLHDVLHS----DKKLTLVFEFCDQDLK--KYFDSCNGDLDPEIVKSFLFQLLK 112 + +IVR+ DV + K L +V E D + D + + + + Sbjct: 67 QCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGE 126 Query: 113 GLGFCHSRNVLHRDLKPQNLLINR---NGELKLADFGLARAFGIPVRCYSAEVVTLWYRP 169 + + HS N+ HRD+KP+NLL N LKL DFG A+ + T +Y Sbjct: 127 AIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKE-TTSHNSLTEPCYTPYYVA 185 Query: 170 PDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPS 229 P+VL G + Y S DMWS G I L P + + G + Sbjct: 186 PEVL-GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNH-------------GLAISPGMKT 231 Query: 230 MTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286 ++ Y+ +++ + L++NLLK P QR++ E + HP+ Sbjct: 232 RIRMGQYEFPNP---------EWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 279 >2Y6O-A nrPDB Length = 291 Score = 199 bits (506), Expect = 1e-51, Method: Composition-based stats. Identities = 50/231 (21%), Positives = 100/231 (43%), Gaps = 9/231 (3%) Query: 5 EKLEKIGEGTYGTVFKAKNRETHEI---VALKRVRLDDDDEGVPSSALREICLLKELKHK 61 + + IG G +G V + + + VA+K ++ D+ L E ++ + H Sbjct: 17 KIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDK-QRRDFLSEASIMGQFDHP 75 Query: 62 NIVRLHDVLHSDKKLTLVFEFCD-QDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 NI+ L V+ K + ++ E+ + L + +G + L + G+ + Sbjct: 76 NIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYLSDM 135 Query: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAF-GIPVRCYSAEVV--TLWYRPPDVLFGAK 177 + +HRDL +N+L+N N K++DFG++R P Y+ + + P+ + K Sbjct: 136 SYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRK 195 Query: 178 LYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWP 228 ++++ D+WS G + E+ + G + D +K I P P Sbjct: 196 -FTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPPMDCP 245 >3HMP-A nrPDB Length = 342 Score = 198 bits (505), Expect = 2e-51, Method: Composition-based stats. Identities = 83/303 (27%), Positives = 132/303 (43%), Gaps = 44/303 (14%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELK-HKN 62 Y L++IG G VF+ N E +I A+K V L++ D S EI L +L+ H + Sbjct: 58 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 116 Query: 63 -IVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN 121 I+RL+D +D+ + +V E + DL + +DP KS+ +L+ + H Sbjct: 117 KIIRLYDYEITDQYIYMVMECGNIDLNSWLKK-KKSIDPWERKSYWKNMLEAVHTIHQHG 175 Query: 122 VLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRC--YSAEVVTLWYRPPDVLFGAK-- 177 ++H DLKP N LI +G LKL DFG+A ++V T+ Y PP+ + Sbjct: 176 IVHSDLKPANFLIV-DGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSS 234 Query: 178 --------LYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPS 229 S D+WS GCI + P + +Q+ ++ ++ E ++P Sbjct: 235 RENGKSKSKISPKSDVWSLGCILYYMTYGKTPF---QQIINQISKLHAIIDPNHEIEFPD 291 Query: 230 MTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDF 289 + + +D+L+ LK +P QRIS E L HPY Sbjct: 292 IPE------------------------KDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQ 327 Query: 290 CPP 292 P Sbjct: 328 THP 330 >4EBW-A nrPDB Length = 304 Score = 198 bits (505), Expect = 2e-51, Method: Composition-based stats. Identities = 61/269 (22%), Positives = 117/269 (43%), Gaps = 14/269 (5%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNR---ETHEIVALKRVRLDDDDEGVPSSALREICLLKEL 58 ++ E IGEG +G V + VA+K + + + V L+E +++ Sbjct: 38 ERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCK-NCTSDSVREKFLQEALTMRQF 96 Query: 59 KHKNIVRLHDVLHSDKKLTLVFEFCD-QDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFC 117 H +IV+L V+ ++ + ++ E C +L+ + LD + + +QL L + Sbjct: 97 DHPHIVKLIGVI-TENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYL 155 Query: 118 HSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEV-VTLWYRPPDVLFGA 176 S+ +HRD+ +N+L++ N +KL DFGL+R +++ + + + P+ + Sbjct: 156 ESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESI-NF 214 Query: 177 KLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPS-----MT 231 + ++++ D+W G E+ G F G +D + RI P P MT Sbjct: 215 RRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMT 274 Query: 232 KLPDYKPYPMYPATTSLVNVVPKLNATGR 260 K Y P P T L + + + Sbjct: 275 KCWAYDPSRR-PRFTELKAQLSTILEEEK 302 >4EQM-A nrPDB Length = 294 Score = 198 bits (504), Expect = 2e-51, Method: Composition-based stats. Identities = 69/273 (25%), Positives = 117/273 (42%), Gaps = 6/273 (2%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLD-DDDEGVPSSALREICLLKELKH 60 ++Y+ ++K+G G TV+ A++ + VA+K + + + E RE+ +L H Sbjct: 11 ERYKIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETLKRFEREVHNSSQLSH 70 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 +NIV + DV D LV E+ + + +G L + +F Q+L G+ H Sbjct: 71 QNIVSMIDVDEEDDCYYLVMEYIEGPTLSEYIESHGPLSVDTAINFTNQILDGIKHAHDM 130 Query: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEV-VTLWYRPPDVLFGAKLY 179 ++HRD+KPQN+LI+ N LK+ DFG+A+A + V T+ Y P+ G Sbjct: 131 RIVHRDIKPQNILIDSNKTLKIFDFGIAKALSETSLTQTNHVLGTVQYFSPEQAKGEAT- 189 Query: 180 STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPY 239 D++S G + E+ P F G I + + +P Sbjct: 190 DECTDIYSIGIVLYEMLVGE-PPFNGETAVSI--AIKHIQDSVPNVTTDVRKDIPQSLSN 246 Query: 240 PMYPATTSLVNVVPKLNATGRDLLQNLLKCNPV 272 + AT K +D L ++L N Sbjct: 247 VILRATEKDKANRYKTIQEMKDDLSSVLHENRA 279 >4Y93-A nrPDB Length = 446 Score = 198 bits (504), Expect = 2e-51, Method: Composition-based stats. Identities = 56/270 (20%), Positives = 113/270 (41%), Gaps = 17/270 (6%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 + L+++G G +G V K R ++ VA+K ++ E + E ++ L H+ Sbjct: 188 KDLTFLKELGTGQFGVVKYGKWRGQYD-VAIKMIKEGSMSED---EFIEEAKVMMNLSHE 243 Query: 62 NIVRLHDVLHSDKKLTLVFEFC-DQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 +V+L+ V + + ++ E+ + L Y + + + + + + S+ Sbjct: 244 KLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESK 303 Query: 121 NVLHRDLKPQNLLINRNGELKLADFGLARA-FGIPVRCYSAEVVTLWYRPPDVLFGAKLY 179 LHRDL +N L+N G +K++DFG+ R + + + P+VL +K + Sbjct: 304 QFLHRDLAARNCLVNDQGVVKVSDFGMTRYVLDDEYTSSTGSKFPVKWASPEVLMYSK-F 362 Query: 180 STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPY 239 S+ D+W+ G + E+ + G+ + + + I + L P P Sbjct: 363 SSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLPR----------PHLASE 412 Query: 240 PMYPATTSLVNVVPKLNATGRDLLQNLLKC 269 +Y S + T + LL N+L Sbjct: 413 RVYAIMYSCWHEKADERPTFKILLSNILDV 442 >6E4F-A nrPDB Length = 290 Score = 198 bits (504), Expect = 2e-51, Method: Composition-based stats. Identities = 59/272 (21%), Positives = 117/272 (43%), Gaps = 21/272 (7%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 + L+++G G +G V K R ++ VA+K ++ E + E ++ L H+ Sbjct: 31 KDLTFLKELGTGQFGVVKYGKWRGQYD-VAIKMIKEGSMSED---EFIEEAKVMMNLSHE 86 Query: 62 NIVRLHDVLHSDKKLTLVFEFC-DQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 +V+L+ V + + ++ E+ + L Y + + + + + + S+ Sbjct: 87 KLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESK 146 Query: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTL---WYRPPDVLFGAK 177 LHRDL +N L+N G +K++DFGL+R Y++ V + + PP+VL +K Sbjct: 147 QFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDD--EYTSSVGSKFPVRWSPPEVLMYSK 204 Query: 178 LYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYK 237 +S+ D+W+ G + E+ + G+ + + + I + L P Sbjct: 205 -FSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYR----------PHLA 253 Query: 238 PYPMYPATTSLVNVVPKLNATGRDLLQNLLKC 269 +Y S + T + LL N+L Sbjct: 254 SEKVYTIMYSCWHEKADERPTFKILLSNILDV 285 >3TT0-A nrPDB Length = 382 Score = 198 bits (504), Expect = 2e-51, Method: Composition-based stats. Identities = 67/291 (23%), Positives = 122/291 (41%), Gaps = 38/291 (13%) Query: 2 QKYEKLEKIGEGTYGTVFKA------KNRETHE-IVALKRVRLDDDDEGVPSSALREICL 54 + + +GEG +G V A K++ VA+K ++ D E S + E+ + Sbjct: 69 DRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLK-SDATEKDLSDLISEMEM 127 Query: 55 LKEL-KHKNIVRLHDVLHSDKKLTLVFEFCD-QDLKKYFDSCNGD--------------- 97 +K + KHKNI+ L D L ++ E+ +L++Y + Sbjct: 128 MKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYSYNPSHNPEEQ 187 Query: 98 LDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRC 157 L + + S +Q+ +G+ + S+ +HRDL +N+L+ + +K+ADFGLAR Sbjct: 188 LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYY 247 Query: 158 YSAEVVTLW--YRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRI 215 L + P+ LF ++Y+ D+WS G + E+ G +PG V++ K + Sbjct: 248 KKTTNGRLPVKWMAPEALFD-RIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLL 306 Query: 216 FRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNL 266 P +Y + VP T + L+++L Sbjct: 307 KEG----------HRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 347 >4UYA-A nrPDB Length = 340 Score = 198 bits (504), Expect = 2e-51, Method: Composition-based stats. Identities = 69/278 (24%), Positives = 111/278 (39%), Gaps = 29/278 (10%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDE--GVPSSALREICLLKELK 59 ++ E E IG G +G V++A + VA+K R D + + S RE L L+ Sbjct: 26 ERLELKELIGAGGFGQVYRATW--QGQEVAVKAARQDPEQDAAAAAESVRREARLFAMLR 83 Query: 60 HKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 H NI+ L V L LV EF + + P ++ ++ Q+ +G+ + H Sbjct: 84 HPNIIELRGVCLQQPHLCLVLEFARGGALNRALA-GRRIPPHVLVNWAVQIARGMLYLHE 142 Query: 120 RN---VLHRDLKPQNLLINR--------NGELKLADFGLARAFGIPVRCYSAEVVTLWYR 168 +LHRDLK N+L+ N LK+ DFGLAR + + +A + Sbjct: 143 EAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTKMATA--GAYAWM 200 Query: 169 PPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWP 228 P+V+ + L+S D+WS G + EL P + + L P Sbjct: 201 APEVI-KSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLTLP------ 253 Query: 229 SMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNL 266 +P P P P + + +L+ L Sbjct: 254 ----IPSTCPEPFAKLMKECWQQDPHIRPSFALILEQL 287 >4OLI-A nrPDB Length = 645 Score = 198 bits (503), Expect = 3e-51, Method: Composition-based stats. Identities = 67/278 (24%), Positives = 120/278 (43%), Gaps = 21/278 (7%) Query: 2 QKY-EKLEKIGEGTYGTV----FKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLK 56 ++Y +K+ +GEG +G V + N T E+VA+K ++ D + S +EI +L+ Sbjct: 352 KRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQ-HRSGWKQEIDILR 410 Query: 57 ELKHKNIVRLHDVLHS--DKKLTLVFEFCD-QDLKKYFDSCNGDLDPEIVKSFLFQLLKG 113 L H++I++ +K L LV E+ L+ Y + L + F Q+ +G Sbjct: 411 TLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGL--AQLLLFAQQICEG 468 Query: 114 LGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYS----AEVVTLWYRP 169 + + HS++ +HR+L +N+L++ + +K+ DFGLA+A Y + WY Sbjct: 469 MAYLHSQHYIHRNLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWY-A 527 Query: 170 PDVLFGAKLYSTSIDMWSAGCIFAELANAG----RPLFPGNDVDDQLKRIFRLLGTPTEE 225 P+ L K Y + D+WS G EL P ++ + +L Sbjct: 528 PECLKEYKFY-YASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELL 586 Query: 226 QWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLL 263 + PD P +Y + T +L+ Sbjct: 587 ERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLI 624 Score = 113 bits (282), Expect = 1e-25, Method: Composition-based stats. Identities = 48/271 (17%), Positives = 89/271 (32%), Gaps = 45/271 (16%) Query: 21 AKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVF 80 ++R V LK + D + + L+ ++ H ++ +H V + +V Sbjct: 88 GRDRGQELRVVLKVL--DPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVT 145 Query: 81 EFCDQDLKK-YFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGE 139 E+ + + G + QL L + ++N++H ++ +N+L+ R G Sbjct: 146 EYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGL 205 Query: 140 -------LKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVL-FGAKLYSTSIDMWSAGCI 191 +KL+D G G+ V + + P+ L GA ST++D W G Sbjct: 206 AEGTSPFIKLSDPG----VGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGAT 261 Query: 192 FAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNV 251 E+ G ++ + P P P + Sbjct: 262 LLEICFDGEAPLQSRSPSEK----------------EHFYQRQHRLPEPSCPQLAT---- 301 Query: 252 VPKLNATGRDLLQNLLKCNPVQRISAEEALQ 282 L L P QR S L+ Sbjct: 302 ----------LTSQCLTYEPTQRPSFRTILR 322 >3SXS-A nrPDB Length = 268 Score = 198 bits (503), Expect = 3e-51, Method: Composition-based stats. Identities = 57/269 (21%), Positives = 118/269 (43%), Gaps = 21/269 (7%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 ++ L+++G G +G V K + ++ VA+K ++ E +E + +L H Sbjct: 8 EEITLLKELGSGQFGVVKLGKWKGQYD-VAVKMIKEGSMSED---EFFQEAQTMMKLSHP 63 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQD-LKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 +V+ + V + + +V E+ L Y S L+P + + + +G+ F S Sbjct: 64 KLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESH 123 Query: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLW---YRPPDVLFGAK 177 +HRDL +N L++R+ +K++DFG+ R Y + V T + + P+V K Sbjct: 124 QFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDD--QYVSSVGTKFPVKWSAPEVFHYFK 181 Query: 178 LYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYK 237 YS+ D+W+ G + E+ + G+ + + + ++ + P Sbjct: 182 -YSSKSDVWAFGILMWEVFSLGKMPYDLYTNSEVVLKVSQ----------GHRLYRPHLA 230 Query: 238 PYPMYPATTSLVNVVPKLNATGRDLLQNL 266 +Y S + +P+ T + LL ++ Sbjct: 231 SDTIYQIMYSCWHELPEKRPTFQQLLSSI 259 >5A46-A nrPDB Length = 386 Score = 197 bits (502), Expect = 4e-51, Method: Composition-based stats. Identities = 67/291 (23%), Positives = 122/291 (41%), Gaps = 38/291 (13%) Query: 2 QKYEKLEKIGEGTYGTVFKA------KNRETHE-IVALKRVRLDDDDEGVPSSALREICL 54 + + +GEG +G V A K++ VA+K ++ D E S + E+ + Sbjct: 40 DRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK-SDATEKDLSDLISEMEM 98 Query: 55 LKEL-KHKNIVRLHDVLHSDKKLTLVFEFCD-QDLKKYFDSCNGD--------------- 97 +K + KHKNI+ L D L ++ E+ +L++Y + Sbjct: 99 MKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQ 158 Query: 98 LDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRC 157 L + + S +Q+ +G+ + S+ +HRDL +N+L+ + +K+ADFGLAR Sbjct: 159 LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYY 218 Query: 158 YSAEVVTLW--YRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRI 215 L + P+ LF ++Y+ D+WS G + E+ G +PG V++ K + Sbjct: 219 KKTTNGRLPVKWMAPEALFD-RIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLL 277 Query: 216 FRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNL 266 P +Y + VP T + L+++L Sbjct: 278 KE----------GHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 318 >1JPA-A nrPDB Length = 312 Score = 197 bits (502), Expect = 4e-51, Method: Composition-based stats. Identities = 50/234 (21%), Positives = 99/234 (42%), Gaps = 11/234 (4%) Query: 5 EKLEKIGEGTYGTVFKAKNRETHEI---VALKRVRLDDDDEGVPSSALREICLLKELKHK 61 + + IG G +G V + + VA+K ++ E L E ++ + H Sbjct: 36 KIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLK-SGYTEKQRRDFLSEASIMGQFDHP 94 Query: 62 NIVRLHDVLHSDKKLTLVFEFCD-QDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 N++ L V+ + ++ EF + L + +G + L + G+ + Sbjct: 95 NVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLADM 154 Query: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVR--CYSAEVV---TLWYRPPDVLFG 175 N +HRDL +N+L+N N K++DFGL+R Y++ + + + P+ + Sbjct: 155 NYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQY 214 Query: 176 AKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPS 229 K ++++ D+WS G + E+ + G + D + I + P PS Sbjct: 215 RK-FTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPS 267 >3PP0-A nrPDB Length = 338 Score = 197 bits (502), Expect = 4e-51, Method: Composition-based stats. Identities = 53/280 (18%), Positives = 107/280 (38%), Gaps = 22/280 (7%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHE----IVALKRVRLDDDDEGVPSSALREICLLKEL 58 + K++ +G G +GTV+K E VA+K +R ++ L E ++ + Sbjct: 18 ELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLR-ENTSPKANKEILDEAYVMAGV 76 Query: 59 KHKNIVRLHDVLHSDKKLTLVFEFCDQD-LKKYFDSCNGDLDPEIVKSFLFQLLKGLGFC 117 + RL + + + LV + L + G L + + ++ Q+ KG+ + Sbjct: 77 GSPYVSRLLGICLTST-VQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYL 135 Query: 118 HSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVV--TLWYRPPDVLFG 175 ++HRDL +N+L+ +K+ DFGLAR I Y A+ + + + + Sbjct: 136 EDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILR 195 Query: 176 AKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPD 235 + ++ D+WS G EL G + G + + + P Sbjct: 196 RR-FTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPIC-------- 246 Query: 236 YKPYPMYPATTSLVNVVPKLNATGRDLLQNL--LKCNPVQ 273 +Y + + R+L+ + +P + Sbjct: 247 --TIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQR 284 >4YHJ-A nrPDB Length = 584 Score = 197 bits (501), Expect = 5e-51, Method: Composition-based stats. Identities = 66/293 (22%), Positives = 121/293 (41%), Gaps = 36/293 (12%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGV-PSSALREICLLKELKHKN 62 + +G+G +G V + R T ++ A K+++ + + AL E +L++++ + Sbjct: 187 FRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQSRF 246 Query: 63 IVRLHDVLHSDKKLTLVFEFCDQDLKKY--FDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 +V L + L LV + K+ ++ N D + + +L GL Sbjct: 247 VVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQRE 306 Query: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYS 180 +++RDLKP+N+L++ G ++++D GLA R V T+ Y P+V+ K Y+ Sbjct: 307 RIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVR-GRVGTVGYMAPEVVNNEK-YT 364 Query: 181 TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYP 240 S D W GC+ E+ P F + + + + + TEE Sbjct: 365 FSPDWWGLGCLIYEMIQGHSP-FKKYKEKVKWEEVDQRIKNDTEE--------------- 408 Query: 241 MYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRI-----SAEEALQHPYFSD 288 K + + + + LL NP +R+ A QHP F D Sbjct: 409 ----------YSEKFSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKD 451 >4UY9-A nrPDB Length = 323 Score = 197 bits (501), Expect = 5e-51, Method: Composition-based stats. Identities = 72/277 (25%), Positives = 112/277 (40%), Gaps = 29/277 (10%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDD--EGVPSSALREICLLKELKH 60 + E IG G +G V++A + VA+K R D D+ + +E L LKH Sbjct: 10 ELTLEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKH 67 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 NI+ L V + L LV EF S + P+I+ ++ Q+ +G+ + H Sbjct: 68 PNIIALRGVCLKEPNLCLVMEFARGGPLNRVLS-GKRIPPDILVNWAVQIARGMNYLHDE 126 Query: 121 N---VLHRDLKPQNLLI--------NRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRP 169 ++HRDLK N+LI N LK+ DFGLAR + + +A T + Sbjct: 127 AIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAA--GTYAWMA 184 Query: 170 PDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPS 229 P+V+ A ++S D+WS G + EL P + + L P Sbjct: 185 PEVI-RASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALP------- 236 Query: 230 MTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNL 266 +P P P N P + ++L L Sbjct: 237 ---IPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQL 270 >2ZMD-A nrPDB Length = 390 Score = 196 bits (499), Expect = 8e-51, Method: Composition-based stats. Identities = 82/303 (27%), Positives = 131/303 (43%), Gaps = 44/303 (14%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELK-HKN 62 Y L++IG G VF+ N E +I A+K V L++ D S EI L +L+ H + Sbjct: 58 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 116 Query: 63 -IVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN 121 I+RL+D +D+ + +V E + DL + +DP KS+ +L+ + H Sbjct: 117 KIIRLYDYEITDQYIYMVMECGNIDLNSWLKK-KKSIDPWERKSYWKNMLEAVHTIHQHG 175 Query: 122 VLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRC--YSAEVVTLWYRPPDVLFGAK-- 177 ++H DLKP N LI +G LKL DFG+A ++V + Y PP+ + Sbjct: 176 IVHSDLKPANFLIV-DGMLKLIDFGIANQMQPDTTSVVKDSQVGAVNYMPPEAIKDMSSS 234 Query: 178 --------LYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPS 229 S D+WS GCI + P + +Q+ ++ ++ E ++P Sbjct: 235 RENGKSKSKISPKSDVWSLGCILYYMTYGKTPF---QQIINQISKLHAIIDPNHEIEFPD 291 Query: 230 MTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDF 289 + + +D+L+ LK +P QRIS E L HPY Sbjct: 292 IPE------------------------KDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQ 327 Query: 290 CPP 292 P Sbjct: 328 THP 330 >3GQL-A nrPDB Length = 326 Score = 196 bits (499), Expect = 1e-50, Method: Composition-based stats. Identities = 67/291 (23%), Positives = 122/291 (41%), Gaps = 38/291 (13%) Query: 2 QKYEKLEKIGEGTYGTVFKA------KNRETHE-IVALKRVRLDDDDEGVPSSALREICL 54 + + +GEG +G V A K++ VA+K ++ D E S + E+ + Sbjct: 28 DRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLK-SDATEKDLSDLISEMEM 86 Query: 55 LKEL-KHKNIVRLHDVLHSDKKLTLVFEFCD-QDLKKYFDSCNGD--------------- 97 +K + KHKNI+ L D L ++ E+ +L++Y + Sbjct: 87 MKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQ 146 Query: 98 LDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRC 157 L + + S +Q+ +G+ + S+ +HRDL +N+L+ + +K+ADFGLAR Sbjct: 147 LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYY 206 Query: 158 YSAEVVTLW--YRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRI 215 L + P+ LF ++Y+ D+WS G + E+ G +PG V++ K + Sbjct: 207 KKTTNGRLPVKWMAPEALFD-RIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLL 265 Query: 216 FRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNL 266 P +Y + VP T + L+++L Sbjct: 266 KE----------GHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 306 >5GNK-A nrPDB Length = 297 Score = 196 bits (498), Expect = 1e-50, Method: Composition-based stats. Identities = 53/281 (18%), Positives = 112/281 (39%), Gaps = 24/281 (8%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIV----ALKRVRLDDDDEGVPSSALREICLLKEL 58 +++K++ +G G +GTV+K E V A+K +R + L E ++ + Sbjct: 20 EFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELR-EATSPKANKEILDEAYVMASV 78 Query: 59 KHKNIVRLHDVLHSDKKLTLVFEFCD-QDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFC 117 + ++ RL + + + L+ + L Y ++ + + ++ Q+ KG+ + Sbjct: 79 DNPHVCRLLGICLTST-VQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYL 137 Query: 118 HSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVV--TLWYRPPDVLFG 175 R ++HRDL +N+L+ +K+ DFGLA+ G + Y AE + + + + Sbjct: 138 EDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESIL- 196 Query: 176 AKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPD 235 ++Y+ D+WS G EL G + G + + + P Sbjct: 197 HRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPIC-------- 248 Query: 236 YKPYPMYPATTSLVNVVPKLNATGRDLL---QNLLKCNPVQ 273 +Y + R+L+ + +P + Sbjct: 249 --TIDVYMIMVKCWMIDADSRPKFRELIIEFSKM-ARDPQR 286 >2VWV-A nrPDB Length = 302 Score = 196 bits (498), Expect = 1e-50, Method: Composition-based stats. Identities = 56/273 (20%), Positives = 112/273 (41%), Gaps = 20/273 (7%) Query: 5 EKLEKIGEGTYGTVFKAKNRETHEI---VALKRVRLDDDDEGVPSSALREICLLKELKHK 61 + E IG G +G V + + + + VA+K ++ E L E ++ + +H Sbjct: 19 KIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLK-GGYTERQRREFLSEASIMGQFEHP 77 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQD-LKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 NI+RL V+ + + ++ EF + L + +G + L + G+ + Sbjct: 78 NIIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGMRYLAEM 137 Query: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAFGI------PVRCYSAEVVTLWYRPPDVLF 174 + +HRDL +N+L+N N K++DFGL+R ++ W P + F Sbjct: 138 SYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTETSSLGGKIPIRWTAPEAIAF 197 Query: 175 GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTK-- 232 + ++++ D WS G + E+ + G + D + I + P P+ Sbjct: 198 --RKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCPTSLHQL 255 Query: 233 -----LPDYKPYPMYPATTSLVNVVPKLNATGR 260 D P +P S ++ + + A+ + Sbjct: 256 MLDCWQKDRNARPRFPQVVSALDKMIRNPASLK 288 >5AP3-A nrPDB Length = 313 Score = 196 bits (498), Expect = 1e-50, Method: Composition-based stats. Identities = 82/303 (27%), Positives = 130/303 (42%), Gaps = 44/303 (14%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELK--HK 61 Y L++IG G VF+ N E +I A+K V L++ D S EI L +L+ Sbjct: 30 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 88 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN 121 I+RL+D +D+ + +V E + DL + +DP KS+ +L+ + H Sbjct: 89 KIIRLYDYEITDQYIYMVMECGNIDLNGWLKK-KKSIDPWERKSYWKNMLEAVHTIHQHG 147 Query: 122 VLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRC--YSAEVVTLWYRPPDVLFGAK-- 177 ++H DLKP N LI +G LKL DFG+A ++V T+ Y PP+ + Sbjct: 148 IVHSDLKPANFLIV-DGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSS 206 Query: 178 --------LYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPS 229 S D+WS GCI + P + +Q+ ++ ++ E ++P Sbjct: 207 RENGKSKSKISPKSDVWSLGCILYYMTYGKTPF---QQIINQISKLHAIIDPNHEIEFPD 263 Query: 230 MTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDF 289 + + +D+L+ LK +P QRIS E L HPY Sbjct: 264 IPE------------------------KDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQ 299 Query: 290 CPP 292 P Sbjct: 300 THP 302 >2J0K-A nrPDB Length = 656 Score = 196 bits (498), Expect = 1e-50, Method: Composition-based stats. Identities = 60/269 (22%), Positives = 116/269 (43%), Gaps = 14/269 (5%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNR---ETHEIVALKRVRLDDDDEGVPSSALREICLLKEL 58 ++ E IGEG +G V + VA+K + + + V L+E +++ Sbjct: 390 ERIELGRCIGEGQFGDVHQGIYMSPENPAMAVAIKTCK-NCTSDSVREKFLQEALTMRQF 448 Query: 59 KHKNIVRLHDVLHSDKKLTLVFEFCD-QDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFC 117 H +IV+L V+ ++ + ++ E C +L+ + LD + + +QL L + Sbjct: 449 DHPHIVKLIGVI-TENPVWIIMELCTLGELRSFLQVRKFSLDLASLILYAYQLSTALAYL 507 Query: 118 HSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEV-VTLWYRPPDVLFGA 176 S+ +HRD+ +N+L++ +KL DFGL+R +++ + + + P+ + Sbjct: 508 ESKRFVHRDIAARNVLVSATDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESI-NF 566 Query: 177 KLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPS-----MT 231 + ++++ D+W G E+ G F G +D + RI P P MT Sbjct: 567 RRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMT 626 Query: 232 KLPDYKPYPMYPATTSLVNVVPKLNATGR 260 K Y P P T L + + + Sbjct: 627 KCWAYDPSRR-PRFTELKAQLSTILEEEK 654 >3ORP-A nrPDB Length = 311 Score = 196 bits (498), Expect = 1e-50, Method: Composition-based stats. Identities = 64/271 (23%), Positives = 107/271 (39%), Gaps = 12/271 (4%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLD-DDDEGVPSSALREICLLKELKH 60 +YE E +G G V A++ H VA+K +R D D RE L H Sbjct: 12 DRYELGEILGFGGMSEVHLARDLRDHRDVAVKVLRADLARDPSFYLRFRREAQNAAALNH 71 Query: 61 KNIVRLHDVLHSDKKL----TLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGF 116 IV ++D ++ +V E+ D + G + P+ + + L F Sbjct: 72 PAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIVHTEGPMTPKRAIEVIADACQALNF 131 Query: 117 CHSRNVLHRDLKPQNLLINRNGELKLADFGLARAF---GIPVRCYSAEVVTLWYRPPDVL 173 H ++HRD+KP N++I+ +K+ DFG+ARA G V +A + T Y P+ Sbjct: 132 SHQNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGTAQYLSPEQA 191 Query: 174 FGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKL 233 G + D++S GC+ E+ P F G+ + R P + ++ Sbjct: 192 RGDSV-DARSDVYSLGCVLYEVLTGE-PPFTGDSPVSVAYQHVREDPIPPSARHEGLSA- 248 Query: 234 PDYKPYPMYPATTSLVNVVPKLNATGRDLLQ 264 D + + N DL++ Sbjct: 249 -DLDAVVLKALAKNPENRYQTAAEMRADLVR 278 >6GQK-A nrPDB Length = 328 Score = 195 bits (497), Expect = 1e-50, Method: Composition-based stats. Identities = 69/306 (22%), Positives = 123/306 (40%), Gaps = 55/306 (17%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNR-----ETHEIVALKRVRLDDDDEGVPSSALREICLLK 56 + + +G G +G V +A + + VA+K ++ + + E+ +L Sbjct: 41 NRLSFGKTLGAGAFGKVVEATAQGLIKSDAAMTVAVKMLK-PSAHSTEREALMSELKVLS 99 Query: 57 EL-KHKNIVRLHDVLHSDKKLTLVFEFC-DQDLKKYFDSCNGD---------------LD 99 L H+NIV L ++ E+C DL + + L Sbjct: 100 YLGNHENIVNLLGACTHGGPTLVITEYCCYGDLLNFLRRKRDEFVPYKVAPEDLYKDFLT 159 Query: 100 PEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIP---VR 156 E + SF +Q+ KG+ F S+N +HRDL +N+L+ K+ DFGLAR V Sbjct: 160 LEHLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGNITKICDFGLARDIKNDSNYVD 219 Query: 157 CYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIF 216 +A + W P+ +F + +Y+ D+WS G EL + G +PG VD + ++ Sbjct: 220 KGNARLPVKW-MAPESIFNS-VYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMI 277 Query: 217 RLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRIS 276 + P+Y P MY D+++ +P +R + Sbjct: 278 K---------EGFRMSSPEYAPAEMY------------------DIMKTCWDADPDKRPT 310 Query: 277 AEEALQ 282 ++ +Q Sbjct: 311 FKQIVQ 316 >3V5Q-A nrPDB Length = 297 Score = 195 bits (497), Expect = 1e-50, Method: Composition-based stats. Identities = 64/298 (21%), Positives = 120/298 (40%), Gaps = 54/298 (18%) Query: 6 KLEKIGEGTYGTVFKAKN-----RETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 ++GEG +G VF A+ + +VA+K ++ RE LL L+H Sbjct: 19 LKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTL--AARKDFQREAELLTNLQH 76 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCD-QDLKKYFDSC---------------NGDLDPEIVK 104 ++IV+ + V L +VFE+ DL K+ + G+L + Sbjct: 77 EHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQML 136 Query: 105 SFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPV--RCYSAEV 162 Q+ G+ + S++ +HRDL +N L+ N +K+ DFG++R R + Sbjct: 137 HIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTM 196 Query: 163 VTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTP 222 + + + PP+ + K ++T D+WS G I E+ G+ + + ++ I Sbjct: 197 LPIRWMPPESIMYRK-FTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECI------- 248 Query: 223 TEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEA 280 + + P P +Y D++ + P QR++ +E Sbjct: 249 ---TQGRVLERPRVCPKEVY------------------DVMLGCWQREPQQRLNIKEI 285 >3DTC-A nrPDB Length = 271 Score = 195 bits (497), Expect = 1e-50, Method: Composition-based stats. Identities = 71/277 (25%), Positives = 111/277 (40%), Gaps = 29/277 (10%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDD--EGVPSSALREICLLKELKH 60 + E IG G +G V++A + VA+K R D D+ + +E L LKH Sbjct: 8 ELTLEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKH 65 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 NI+ L V + L LV EF S + P+I+ ++ Q+ +G+ + H Sbjct: 66 PNIIALRGVCLKEPNLCLVMEFARGGPLNRVLS-GKRIPPDILVNWAVQIARGMNYLHDE 124 Query: 121 N---VLHRDLKPQNLLI--------NRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRP 169 ++HRDLK N+LI N LK+ DFGLAR + + +A + Sbjct: 125 AIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAA--GAYAWMA 182 Query: 170 PDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPS 229 P+V+ A ++S D+WS G + EL P + + L P Sbjct: 183 PEVI-RASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALP------- 234 Query: 230 MTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNL 266 +P P P N P + ++L L Sbjct: 235 ---IPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQL 268 >5SYS-A nrPDB Length = 286 Score = 195 bits (497), Expect = 2e-50, Method: Composition-based stats. Identities = 66/290 (22%), Positives = 121/290 (41%), Gaps = 43/290 (14%) Query: 9 KIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHD 68 K+G+G +G + T VA+K ++ P + L+E ++K+L+H+ +V+L+ Sbjct: 25 KLGQGCFGECWMGTWNGTTR-VAIKTLKPGTMS---PEAFLQEAQVMKKLRHEKLVQLYA 80 Query: 69 VLHSDKKLTLVFEFCD-QDLKKYFD-SCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRD 126 V+ S++ + +V E+ L + L + Q+ G+ + N +HRD Sbjct: 81 VV-SEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRD 139 Query: 127 LKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLW---YRPPDVLFGAKLYSTSI 183 L+ N+L+ N K+ADFGLAR Y+A + + P+ + ++ Sbjct: 140 LRAANILVGENLVCKVADFGLARLI--EDNEYTARQGAKFPIKWTAPEAALYGR-FTIKS 196 Query: 184 DMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYP 243 D+WS G + EL GR +PG + L ++ R P + P Sbjct: 197 DVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECP--------------- 241 Query: 244 ATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAE--EALQHPYFSDFCP 291 + DL+ + +P +R + E +A YF+ P Sbjct: 242 -------------ESLHDLMCQCWRKDPEERPTFEYLQAFLEDYFTSTEP 278 >3LZB-A nrPDB Length = 327 Score = 195 bits (497), Expect = 2e-50, Method: Composition-based stats. Identities = 53/281 (18%), Positives = 112/281 (39%), Gaps = 24/281 (8%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIV----ALKRVRLDDDDEGVPSSALREICLLKEL 58 +++K++ +G G +GTV+K E V A+K +R + L E ++ + Sbjct: 16 EFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELR-EATSPKANKEILDEAYVMASV 74 Query: 59 KHKNIVRLHDVLHSDKKLTLVFEFCD-QDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFC 117 + ++ RL + + + L+ + L Y ++ + + ++ Q+ KG+ + Sbjct: 75 DNPHVCRLLGICLTST-VQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYL 133 Query: 118 HSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVV--TLWYRPPDVLFG 175 R ++HRDL +N+L+ +K+ DFGLA+ G + Y AE + + + + Sbjct: 134 EDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESIL- 192 Query: 176 AKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPD 235 ++Y+ D+WS G EL G + G + + + P Sbjct: 193 HRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPIC-------- 244 Query: 236 YKPYPMYPATTSLVNVVPKLNATGRDLL---QNLLKCNPVQ 273 +Y + R+L+ + +P + Sbjct: 245 --TIDVYMIMRKCWMIDADSRPKFRELIIEFSKM-ARDPQR 282 >3OMV-A nrPDB Length = 307 Score = 195 bits (497), Expect = 2e-50, Method: Composition-based stats. Identities = 63/280 (22%), Positives = 117/280 (41%), Gaps = 27/280 (9%) Query: 9 KIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHD 68 +IG G++GTV+K K VA+K +++ D + E+ +L++ +H NI+ Sbjct: 43 RIGSGSFGTVYKGKWHGD---VAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMG 99 Query: 69 VLHSDKKLTLVFEFCDQD-LKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDL 127 + + L +V ++C+ L K+ + Q +G+ + H++N++HRD+ Sbjct: 100 YM-TKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDM 158 Query: 128 KPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVT--LWYRPPDVL--FGAKLYSTSI 183 K N+ ++ +K+ DFGLA E T + + P+V+ +S Sbjct: 159 KSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQS 218 Query: 184 DMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYP 243 D++S G + EL P N+ D + + R +P ++KL P M Sbjct: 219 DVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASP------DLSKLYKNCPKAMKR 272 Query: 244 ATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQH 283 V V + +L ++ E LQH Sbjct: 273 LVADCVKKVKEERPLFPQILSSI------------ELLQH 300 >3BBT-B nrPDB Length = 328 Score = 195 bits (496), Expect = 2e-50, Method: Composition-based stats. Identities = 56/300 (18%), Positives = 120/300 (40%), Gaps = 18/300 (6%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIV----ALKRVRLDDDDEGVPSSALREICLLKEL 58 + ++++ +G G +GTV+K E V A+K + + + E ++ + Sbjct: 16 ELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILN-ETTGPKANVEFMDEALIMASM 74 Query: 59 KHKNIVRLHDVLHSDKKLTLVFEFCDQD-LKKYFDSCNGDLDPEIVKSFLFQLLKGLGFC 117 H ++VRL V S + LV + L +Y ++ +++ ++ Q+ KG+ + Sbjct: 75 DHPHLVRLLGVCLSPT-IQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYL 133 Query: 118 HSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVV--TLWYRPPDVLFG 175 R ++HRDL +N+L+ +K+ DFGLAR + Y+A+ + + + + Sbjct: 134 EERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHY 193 Query: 176 AKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWP-SMTKLP 234 K ++ D+WS G EL G + G + + + P + + Sbjct: 194 RK-FTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVM 252 Query: 235 DYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKC---NPVQRISAEEALQHPYFSDFCP 291 + + + + RD Q L + ++ S ++ +F + Sbjct: 253 VKCWMIDADSRPKFKELAAEFSRMARD-PQRYLVIQGDDRMKLPSPNDSK---FFQNLLD 308 >6DBM-A nrPDB Length = 318 Score = 195 bits (496), Expect = 2e-50, Method: Composition-based stats. Identities = 67/278 (24%), Positives = 118/278 (42%), Gaps = 21/278 (7%) Query: 2 QKY-EKLEKIGEGTYGTV----FKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLK 56 ++Y +K+ +GEG +G V + N T E+VA+K ++ D + S +EI +L+ Sbjct: 30 KRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAGPQ-HRSGWKQEIDILR 88 Query: 57 ELKHKNIVRLHDVLHSDK--KLTLVFEFCD-QDLKKYFDSCNGDLDPEIVKSFLFQLLKG 113 L H++I++ L LV E+ L+ Y + L + F Q+ +G Sbjct: 89 TLYHEHIIKYKGCCEDAGAASLQLVMEYVPLGSLRDYLPRHSIGL--AQLLLFAQQICEG 146 Query: 114 LGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYS----AEVVTLWYRP 169 + + HS++ +HRDL +N+L++ + +K+ DFGLA+A Y + WY Sbjct: 147 MAYLHSQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWY-A 205 Query: 170 PDVLFGAKLYSTSIDMWSAGCIFAELANAG----RPLFPGNDVDDQLKRIFRLLGTPTEE 225 P+ L K Y + D+WS G EL P ++ + +L Sbjct: 206 PECLKEYKFY-YASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELL 264 Query: 226 QWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLL 263 + PD P +Y + T +L+ Sbjct: 265 ERGERLPRPDKCPAEVYHLMKNCWETEASFRPTFENLI 302 >2PSQ-A nrPDB Length = 370 Score = 195 bits (495), Expect = 2e-50, Method: Composition-based stats. Identities = 70/291 (24%), Positives = 124/291 (42%), Gaps = 38/291 (13%) Query: 2 QKYEKLEKIGEGTYGTVFKA------KNRETHEI-VALKRVRLDDDDEGVPSSALREICL 54 K + +GEG +G V A K++ + VA+K ++ DD E S + E+ + Sbjct: 81 DKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLK-DDATEKDLSDLVSEMEM 139 Query: 55 LKEL-KHKNIVRLHDVLHSDKKLTLVFEFCD-QDLKKYFDSCNGD--------------- 97 +K + KHKNI+ L D L ++ E+ +L++Y + Sbjct: 140 MKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQ 199 Query: 98 LDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRC 157 + + + S +QL +G+ + S+ +HRDL +N+L+ N +K+ADFGLAR Sbjct: 200 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY 259 Query: 158 YSAEVVTLW--YRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRI 215 L + P+ LF ++Y+ D+WS G + E+ G +PG V++ K + Sbjct: 260 KKTTNGRLPVKWMAPEALFD-RVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLL 318 Query: 216 FRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNL 266 P +Y + VP T + L+++L Sbjct: 319 KEG----------HRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 359 >4K33-A nrPDB Length = 325 Score = 195 bits (495), Expect = 3e-50, Method: Composition-based stats. Identities = 62/290 (21%), Positives = 124/290 (42%), Gaps = 38/290 (13%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHE-------IVALKRVRLDDDDEGVPSSALREICLL 55 + + +GEG +G V A+ + VA+K ++ DD + S + E+ ++ Sbjct: 37 RLTLGKPLGEGAFGQVVMAEAIGIDKDRAAKPVTVAVKMLK-DDATDKDLSDLVSEMEMM 95 Query: 56 KEL-KHKNIVRLHDVLHSDKKLTLVFEFC-DQDLKKYFDSCNGD---------------L 98 K + KHKNI+ L L ++ E+ +L+++ + L Sbjct: 96 KMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTSKPPEEQL 155 Query: 99 DPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFG--IPVR 156 + + S +Q+ +G+ + S+ +HRDL +N+L+ + +K+ADFGLAR + Sbjct: 156 TFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYK 215 Query: 157 CYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIF 216 + + + + P+ LF ++Y+ D+WS G + E+ G +PG V++ K + Sbjct: 216 ETTNGRLPVKWMAPEALFD-RVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLK 274 Query: 217 RLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNL 266 P + +Y + P T + L+++L Sbjct: 275 E----------GHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDL 314 >4PDO-A nrPDB Length = 299 Score = 194 bits (494), Expect = 3e-50, Method: Composition-based stats. Identities = 54/230 (23%), Positives = 101/230 (43%), Gaps = 10/230 (4%) Query: 8 EKIGEGTYGTVFKAKNR----ETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 + IG G +G V+K + + VA+K ++ E L E ++ + H NI Sbjct: 40 KVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAG-YTEKQRVDFLGEAGIMGQFSHHNI 98 Query: 64 VRLHDVLHSDKKLTLVFEFCDQD-LKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNV 122 +RL V+ K + ++ E+ + L K+ +G+ + L + G+ + + N Sbjct: 99 IRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAGMKYLANMNY 158 Query: 123 LHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVV---TLWYRPPDVLFGAKLY 179 +HRDL +N+L+N N K++DFGL+R + + P+ + K + Sbjct: 159 VHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYRK-F 217 Query: 180 STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPS 229 +++ D+WS G + E+ G + + +K I PT PS Sbjct: 218 TSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPS 267 >1BYG-A nrPDB Length = 278 Score = 194 bits (494), Expect = 4e-50, Method: Composition-based stats. Identities = 61/269 (22%), Positives = 118/269 (43%), Gaps = 23/269 (8%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 M++ + L+ IG+G +G V R VA+K ++ ++ + L E ++ +L+H Sbjct: 20 MKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIK----NDATAQAFLAEASVMTQLRH 73 Query: 61 KNIVRLHDVL-HSDKKLTLVFEFC-DQDLKKYFDSCNGD-LDPEIVKSFLFQLLKGLGFC 117 N+V+L V+ L +V E+ L Y S L + + F + + + + Sbjct: 74 SNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYL 133 Query: 118 HSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAK 177 N +HRDL +N+L++ + K++DFGL + + ++ W P+ L K Sbjct: 134 EGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQD--TGKLPVKWT-APEAL-REK 189 Query: 178 LYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYK 237 +ST D+WS G + E+ + GR +P + D + R+ + PD Sbjct: 190 KFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKM----------DAPDGC 239 Query: 238 PYPMYPATTSLVNVVPKLNATGRDLLQNL 266 P +Y + ++ + + L + L Sbjct: 240 PPAVYEVMKNCWHLDAAMRPSFLQLREQL 268 >4OTD-A nrPDB Length = 341 Score = 194 bits (494), Expect = 4e-50, Method: Composition-based stats. Identities = 69/297 (23%), Positives = 123/297 (41%), Gaps = 43/297 (14%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVP-SSALREICLLKEL- 58 ++ ++ L +G G +G V ++ R + E+ A+K ++ D S + E +L + Sbjct: 11 LEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVT 70 Query: 59 --KHKNIVRLHDVLHSDKKLTLVFEF-CDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLG 115 H +V L + + + V E+ DL + S + ++ GL Sbjct: 71 SAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHS--DVFSEPRAIFYSACVVLGLQ 128 Query: 116 FCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFG 175 F H +++RDLK NLL++ G +K+ADFGL + S T + P+VL Sbjct: 129 FLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTD 188 Query: 176 AKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPD 235 Y+ ++D W G + E+ P FPG+D ++ I D Sbjct: 189 TS-YTRAVDWWGLGVLLYEMLVGESP-FPGDDEEEVFDSIVN-----------------D 229 Query: 236 YKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRIS-----AEEALQHPYFS 287 YP + L+A +++ LL+ NP +R+ AE+ + P+F Sbjct: 230 EVRYPRF------------LSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFFR 274 >1K9A-A nrPDB Length = 450 Score = 194 bits (493), Expect = 5e-50, Method: Composition-based stats. Identities = 62/269 (23%), Positives = 117/269 (43%), Gaps = 23/269 (8%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 M++ + L+ IG+G +G V R VA+K ++ ++ + L E ++ +L+H Sbjct: 192 MKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIK----NDATAQAFLAEASVMTQLRH 245 Query: 61 KNIVRLHDVL-HSDKKLTLVFEFC-DQDLKKYFDSCNGD-LDPEIVKSFLFQLLKGLGFC 117 N+V+L V+ L +V E+ L Y S L + + F + + + + Sbjct: 246 SNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYL 305 Query: 118 HSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAK 177 N +HRDL +N+L++ + K++DFGL + + ++ W P+ L K Sbjct: 306 EGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQD--TGKLPVKWT-APEAL-REK 361 Query: 178 LYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYK 237 +ST D+WS G + E+ + GR +P + D + R+ + PD Sbjct: 362 KFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKM----------DAPDGC 411 Query: 238 PYPMYPATTSLVNVVPKLNATGRDLLQNL 266 P +Y + ++ T L + L Sbjct: 412 PPAVYDVMKNCWHLDAATRPTFLQLREQL 440 >5HI2-A nrPDB Length = 283 Score = 193 bits (492), Expect = 5e-50, Method: Composition-based stats. Identities = 53/270 (19%), Positives = 116/270 (42%), Gaps = 19/270 (7%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62 + ++IG G++GTV+K K VA+K + + E+ +L++ +H N Sbjct: 21 QITVGQRIGSGSFGTVYKGKWHGD---VAVKML-----TPQQLQAFKNEVGVLRKTRHVN 72 Query: 63 IVRLHDVLHSDKKLTLVFEFCDQD-LKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN 121 I+ + +L +V ++C+ L + + + + + Q +G+ + H+++ Sbjct: 73 ILLFMG-YSTKPQLAIVTQWCEGSSLYHHLHASETKFEMKKLIDIARQTARGMDYLHAKS 131 Query: 122 VLHRDLKPQNLLINRNGELKLADFGLARAFG--IPVRCYSAEVVTLWYRPPDVL--FGAK 177 ++HRDLK N+ ++ + +K+ DFGLA + ++ + P+V+ + Sbjct: 132 IIHRDLKSNNIFLHEDNTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDSN 191 Query: 178 LYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQ-----WPSMTK 232 YS D+++ G + EL P N+ D ++ + R +P + M + Sbjct: 192 PYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEMVGRGSLSPDLSKVRSNCPKRMKR 251 Query: 233 LPDYKPYPMYPATTSLVNVVPKLNATGRDL 262 L S ++ ++ R+L Sbjct: 252 LMAECLKKKRDERPSFPRILAEIEELAREL 281 >4IAN-A nrPDB Length = 358 Score = 193 bits (492), Expect = 5e-50, Method: Composition-based stats. Identities = 86/328 (26%), Positives = 141/328 (42%), Gaps = 48/328 (14%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNR-ETHEIVALKRVRLDDDDEGVPSSALREICLLKEL-- 58 ++Y G+G + V +A++ ++ VA+K +R ++E + + L+E+ LK+L Sbjct: 30 KRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIR---NNELMQKTGLKELEFLKKLND 86 Query: 59 ----KHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEI--VKSFLFQLLK 112 + +RL + + L LVFE +L++ D+ I V+S+ QL Sbjct: 87 ADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVGLHIKAVRSYSQQLFL 146 Query: 113 GLGFCHSRNVLHRDLKPQNLLINRNGEL-KLADFGLARAFGIPVRCYSAEVVTLWYRPPD 171 L N+LH D+KP N+L+N + + KL DFG A + +V+ +YR P+ Sbjct: 147 ALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASHVADND--ITPYLVSRFYRAPE 204 Query: 172 VLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLG-TPTEEQWPSM 230 ++ G K Y IDMWS GC EL LFPG + LK L G P + + Sbjct: 205 IIIG-KSYDYGIDMWSVGCTLYELYTGKI-LFPGKTNNHMLKLAMDLKGKMPNKMIRKGV 262 Query: 231 TKLPDYKPYPMYP-------ATTSLVNVVPKLNA-----------------------TGR 260 K + + V V+ +N + Sbjct: 263 FKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLADLIGCQRLPEDQRKKVHQLK 322 Query: 261 DLLQNLLKCNPVQRISAEEALQHPYFSD 288 DLL +L +P +RIS +ALQH + + Sbjct: 323 DLLDQILMLDPAKRISINQALQHAFIQE 350 >3A4O-X nrPDB Length = 286 Score = 193 bits (491), Expect = 8e-50, Method: Composition-based stats. Identities = 54/233 (23%), Positives = 109/233 (46%), Gaps = 12/233 (5%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 + + ++++G G +G V+ + + VA+K ++ + L E L+K L+H Sbjct: 13 ESIKLVKRLGAGQFGEVWMGYYNNSTK-VAVKTLKPGTMS---VQAFLEEANLMKTLQHD 68 Query: 62 NIVRLHDVLHSDKKLTLVFEFC-DQDLKKYFDS-CNGDLDPEIVKSFLFQLLKGLGFCHS 119 +VRL+ V+ ++ + ++ E+ L + S G + + F Q+ +G+ + Sbjct: 69 KLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIER 128 Query: 120 RNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLW---YRPPDVLFGA 176 +N +HRDL+ N+L++ + K+ADFGLAR Y+A + + P+ + Sbjct: 129 KNYIHRDLRAANVLVSESLMCKIADFGLARVI--EDNEYTAREGAKFPIKWTAPEAI-NF 185 Query: 177 KLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPS 229 ++ D+WS G + E+ G+ +PG D + + + P E P Sbjct: 186 GCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPD 238 >4XCU-A nrPDB Length = 300 Score = 193 bits (490), Expect = 1e-49, Method: Composition-based stats. Identities = 62/282 (21%), Positives = 121/282 (42%), Gaps = 29/282 (10%) Query: 2 QKYEKLEKIGEGTYGTVFKAK-------NRETHEIVALKRVRLDDDDEGVPSSALREICL 54 + + +GEG +G V +A+ + VA+K ++ D+ + + + E+ + Sbjct: 17 DRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLK-DNASDKDLADLVSEMEV 75 Query: 55 LKEL-KHKNIVRLHDVLHSDKKLTLVFEFC-DQDLKKYFDSCN------GDLDPEIVKSF 106 +K + +HKNI+ L V + L ++ E +L+++ + G L ++ S Sbjct: 76 MKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGSSEGPLSFPVLVSC 135 Query: 107 LFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLW 166 +Q+ +G+ + SR +HRDL +N+L+ + +K+ADFGLAR L Sbjct: 136 AYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLP 195 Query: 167 --YRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTE 224 + P+ LF ++Y+ D+WS G + E+ G +PG V++ + Sbjct: 196 VKWMAPEALFD-RVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRP 254 Query: 225 EQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNL 266 P +Y + P T + L++ L Sbjct: 255 PHCP----------PELYGLMRECWHAAPSQRPTFKQLVEAL 286 >1ZXE-A nrPDB Length = 303 Score = 193 bits (490), Expect = 1e-49, Method: Composition-based stats. Identities = 72/312 (23%), Positives = 128/312 (41%), Gaps = 59/312 (18%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62 +E++ +G+G +G V KA+N A+K++R E S+ L E+ LL L H+ Sbjct: 7 DFEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRH---TEEKLSTILSEVMLLASLNHQY 63 Query: 63 IVRLHDVLHSDKK-------------LTLVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFLF 108 +VR + + L + E+C+ L S N + + Sbjct: 64 VVRYYAAWLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQRDEYWRLFR 123 Query: 109 QLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGI--------------P 154 Q+L+ L + HS+ ++HR+LKP N+ I+ + +K+ DFGLA+ Sbjct: 124 QILEALSYIHSQGIIHRNLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKLDSQNLPGS 183 Query: 155 VRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKR 214 ++ + T Y +VL G Y+ IDM+S G IF E+ P G + + LK+ Sbjct: 184 SDNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMI---YPFSTGMERVNILKK 240 Query: 215 IFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQR 274 + + S+ PD+ M + +++ L+ +P +R Sbjct: 241 LRSV----------SIEFPPDFDDNKMKVE---------------KKIIRLLIDHDPNKR 275 Query: 275 ISAEEALQHPYF 286 A L + Sbjct: 276 PGARTLLNSGWL 287 >4GS6-A nrPDB Length = 315 Score = 192 bits (489), Expect = 1e-49, Method: Composition-based stats. Identities = 69/288 (23%), Positives = 113/288 (39%), Gaps = 46/288 (15%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 ++ E E +G G +G V KAK R + VA+K++ + E + + E+ L + H Sbjct: 9 KEIEVEEVVGRGAFGVVCKAKWRA--KDVAIKQI----ESESERKAFIVELRQLSRVNHP 62 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLD---PEIVKSFLFQLLKGLGFCH 118 NIV+L+ + LV E+ + L S+ Q +G+ + H Sbjct: 63 NIVKLYGACL--NPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLH 120 Query: 119 SRN---VLHRDLKPQNLLINRNGEL-KLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLF 174 S ++HRDLKP NLL+ G + K+ DFG A + + + P+V Sbjct: 121 SMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQ---THMTNNKGSAAWMAPEVFE 177 Query: 175 GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLP 234 G+ YS D++S G I E+ +P D+ FR++ P + K Sbjct: 178 GS-NYSEKCDVFSWGIILWEVITRRKPF------DEIGGPAFRIMWAVHNGTRPPLIK-- 228 Query: 235 DYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQ 282 L L+ +P QR S EE ++ Sbjct: 229 -------------------NLPKPIESLMTRCWSKDPSQRPSMEEIVK 257 >3CJF-A nrPDB Length = 309 Score = 192 bits (489), Expect = 1e-49, Method: Composition-based stats. Identities = 67/286 (23%), Positives = 122/286 (42%), Gaps = 32/286 (11%) Query: 2 QKYEKLEKIGEGTYGTVFKA----KNR-ETHEIVALKRVRLDDDDEGVPSSALREICLLK 56 + + +G G +G V +A ++ T VA+K ++ + + + E+ +L Sbjct: 27 DRLNLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLK-EGATHSEHRALMSELKILI 85 Query: 57 ELKHK-NIVRLHDVLHS-DKKLTLVFEFCD-QDLKKYFDSCNGD-----------LDPEI 102 + H N+V L L ++ EFC +L Y S + L E Sbjct: 86 HIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKDLYKDFLTLEH 145 Query: 103 VKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRC--YSA 160 + + FQ+ KG+ F SR +HRDL +N+L++ +K+ DFGLAR Sbjct: 146 LICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGD 205 Query: 161 EVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLG 220 + L + P+ +F ++Y+ D+WS G + E+ + G +PG +D++ R + Sbjct: 206 ARLPLKWMAPETIFD-RVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLK--- 261 Query: 221 TPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNL 266 + + PDY MY + P T +L+++L Sbjct: 262 ------EGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHL 301 >5KMM-A nrPDB Length = 329 Score = 192 bits (488), Expect = 2e-49, Method: Composition-based stats. Identities = 58/261 (22%), Positives = 107/261 (40%), Gaps = 30/261 (11%) Query: 9 KIGEGTYGTVFKAKNRE-----THEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 ++GEG +G VF A+ +VA+K ++ + E RE LL L+H++I Sbjct: 42 ELGEGAFGKVFLAECHNLLPEQDKMLVAVKALK--EASESARQDFQREAELLTMLQHQHI 99 Query: 64 VRLHDVLHSDKKLTLVFEFC-DQDLKKYFDSCN--------------GDLDPEIVKSFLF 108 VR V + L +VFE+ DL ++ S G L + + Sbjct: 100 VRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVAS 159 Query: 109 QLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPV--RCYSAEVVTLW 166 Q+ G+ + + +HRDL +N L+ + +K+ DFG++R R ++ + Sbjct: 160 QVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIR 219 Query: 167 YRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRI-----FRLLGT 221 + PP+ + K ++T D+WS G + E+ G+ + + + I Sbjct: 220 WMPPESILYRK-FTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRA 278 Query: 222 PTEEQWPSMTKLPDYKPYPMY 242 E + M +P + Sbjct: 279 CPPEVYAIMRGCWQREPQQRH 299 >5X02-A nrPDB Length = 347 Score = 192 bits (488), Expect = 2e-49, Method: Composition-based stats. Identities = 66/297 (22%), Positives = 116/297 (39%), Gaps = 41/297 (13%) Query: 2 QKYEKLEKIGEGTYGTVFKAK-----NRETHEIVALKRVRLDDDDEGVPSSALREICLLK 56 + E + +G G +G V A VA+K ++ + D + + E+ ++ Sbjct: 48 ENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLK-EKADSSEREALMSELKMMT 106 Query: 57 EL-KHKNIVRLHDVLHSDKKLTLVFEFC-DQDLKKYFDSCNGDLDPEIVKS--------- 105 +L H+NIV L + L+FE+C DL Y S + ++ Sbjct: 107 QLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRLEEE 166 Query: 106 -------------FLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFG 152 F +Q+ KG+ F ++ +HRDL +N+L+ +K+ DFGLAR Sbjct: 167 EDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIM 226 Query: 153 IPVRC--YSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDD 210 + + + P+ LF +Y+ D+WS G + E+ + G +PG VD Sbjct: 227 SDSNYVVRGNARLPVKWMAPESLFEG-IYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDA 285 Query: 211 QLKRIFR------LLGTPTEEQWPSMTKLP--DYKPYPMYPATTSLVNVVPKLNATG 259 ++ + TEE + M D + P +P TS + Sbjct: 286 NFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEA 342 >5VO2-A nrPDB Length = 300 Score = 191 bits (486), Expect = 3e-49, Method: Composition-based stats. Identities = 62/282 (21%), Positives = 104/282 (36%), Gaps = 41/282 (14%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 ++ L+ +G G G VF + E VA+K+VR + + I L++LKH Sbjct: 12 EEILDLQWVGSGAQGAVFLGRFH--GEEVAVKKVRDLKETD---------IKHLRKLKHP 60 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN 121 NI+ V ++ EFC Q + P ++ + + G+ + H Sbjct: 61 NIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHK 120 Query: 122 VLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYST 181 ++HRDLK N+LI + +K++DFG ++ S T+ + P+V+ + S Sbjct: 121 IIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMS-FAGTVAWMAPEVIRNEPV-SE 178 Query: 182 SIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPM 241 +D+WS G + EL P + L P P K+ Sbjct: 179 KVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKI-------- 230 Query: 242 YPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQH 283 LL+ P R S + L H Sbjct: 231 --------------------LLRQCWNSKPRNRPSFRQILLH 252 >4E20-A nrPDB Length = 290 Score = 191 bits (485), Expect = 3e-49, Method: Composition-based stats. Identities = 66/278 (23%), Positives = 119/278 (42%), Gaps = 21/278 (7%) Query: 2 QKY-EKLEKIGEGTYGTV----FKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLK 56 ++Y +K+ +GEG +G V + N T E+VA+K ++ + + S REI +L+ Sbjct: 7 KRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALK-EGCGPQLRSGWQREIEILR 65 Query: 57 ELKHKNIVRLHDVLHS--DKKLTLVFEFCD-QDLKKYFDSCNGDLDPEIVKSFLFQLLKG 113 L H++IV+ +K + LV E+ L+ Y L + F Q+ +G Sbjct: 66 TLYHEHIVKYKGCCEDQGEKSVQLVMEYVPLGSLRDYLPRHCVGL--AQLLLFAQQICEG 123 Query: 114 LGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYS----AEVVTLWYRP 169 + + H+++ +HR L +N+L++ + +K+ DFGLA+A Y + WY Sbjct: 124 MAYLHAQHYIHRALAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWY-A 182 Query: 170 PDVLFGAKLYSTSIDMWSAGCIFAELANAG----RPLFPGNDVDDQLKRIFRLLGTPTEE 225 P+ L K Y + D+WS G EL P ++ + +L Sbjct: 183 PECLKECKFY-YASDVWSFGVTLYELLTYCDSNQSPHTKFTELIGHTQGQMTVLRLTELL 241 Query: 226 QWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLL 263 + PD P +Y + T ++L+ Sbjct: 242 ERGERLPRPDRCPCEIYHLMKNCWETEASFRPTFQNLV 279 >4XUF-A nrPDB Length = 297 Score = 191 bits (485), Expect = 4e-49, Method: Composition-based stats. Identities = 66/287 (22%), Positives = 116/287 (40%), Gaps = 41/287 (14%) Query: 2 QKYEKLEKIGEGTYGTVFKAK-----NRETHEIVALKRVRLDDDDEGVPSSALREICLLK 56 + E + +G G +G V A VA+K ++ + D + + E+ ++ Sbjct: 9 ENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLK-EKADSSEREALMSELKMMT 67 Query: 57 EL-KHKNIVRLHDVLHSDKKLTLVFEFC-DQDLKKYFDSCNGDLDPEIVKS--------- 105 +L H+NIV L + L+FE+C DL Y S + ++ Sbjct: 68 QLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRLEEE 127 Query: 106 -------------FLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFG 152 F +Q+ KG+ F ++ +HRDL +N+L+ +K+ DFGLAR Sbjct: 128 EDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIM 187 Query: 153 IPVRC--YSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDD 210 + + + P+ LF +Y+ D+WS G + E+ + G +PG VD Sbjct: 188 SDSNYVVRGNARLPVKWMAPESLFEG-IYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDA 246 Query: 211 QLKRIFR------LLGTPTEEQWPSMTKLP--DYKPYPMYPATTSLV 249 ++ + TEE + M D + P +P TS + Sbjct: 247 NFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFL 293 >4LRM-A nrPDB Length = 334 Score = 190 bits (484), Expect = 4e-49, Method: Composition-based stats. Identities = 53/284 (18%), Positives = 112/284 (39%), Gaps = 27/284 (9%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIV----ALKRVRLDDDDEGVPSSALREICLLKEL 58 +++K++ +G G +GTV+K E V A+K +R + L E ++ + Sbjct: 20 EFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELR-EATSPKANKEILDEAYVMASV 78 Query: 59 KHK---NIVRLHDVLHSDKKLTLVFEFCD-QDLKKYFDSCNGDLDPEIVKSFLFQLLKGL 114 + ++ RL + + + L+ + L Y ++ + + ++ Q+ KG+ Sbjct: 79 DNPGNPHVCRLLGICLTST-VQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGM 137 Query: 115 GFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVV--TLWYRPPDV 172 + R ++HRDL +N+L+ +K+ DFGLA+ G + Y AE + + + Sbjct: 138 NYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALES 197 Query: 173 LFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTK 232 + ++Y+ D+WS G EL G + G + + + P Sbjct: 198 IL-HRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPIC----- 251 Query: 233 LPDYKPYPMYPATTSLVNVVPKLNATGRDLL---QNLLKCNPVQ 273 +Y + R+L+ + +P + Sbjct: 252 -----TIDVYMIMVKCWMIDADSRPKFRELIIEFSKM-ARDPQR 289 >4XLV-A nrPDB Length = 328 Score = 190 bits (484), Expect = 5e-49, Method: Composition-based stats. Identities = 60/308 (19%), Positives = 116/308 (37%), Gaps = 53/308 (17%) Query: 2 QKYEKLEKIGEGTYGTVFK--AKNRETHE---IVALKRVRLDDDDEGVPSSALREICLLK 56 +K L ++G+G++G V++ A++ E VA+K V + L E ++K Sbjct: 39 EKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVN-ESASLRERIEFLNEASVMK 97 Query: 57 ELKHKNIVRLHDVLHSDKKLTLVFEFC-DQDLKKYFDSCNGDLD---------PEIVKSF 106 ++VRL V+ + +V E DLK Y S + + + + Sbjct: 98 GFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQM 157 Query: 107 LFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVV--T 164 ++ G+ + +++ +HRDL +N ++ + +K+ DFG+ R Sbjct: 158 AAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLP 217 Query: 165 LWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTE 224 + + P+ L +++TS DMWS G + E+ + + G + LK + Sbjct: 218 VRWMAPESLKDG-VFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQP 276 Query: 225 EQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQ-- 282 + P DL++ + NP R + E + Sbjct: 277 DNCPERVT----------------------------DLMRMCWQFNPNMRPTFLEIVNLL 308 Query: 283 ----HPYF 286 HP F Sbjct: 309 KDDLHPSF 316 >5EG3-A nrPDB Length = 334 Score = 190 bits (484), Expect = 5e-49, Method: Composition-based stats. Identities = 68/291 (23%), Positives = 126/291 (43%), Gaps = 38/291 (13%) Query: 2 QKYEKLEKIGEGTYGTVFKA------KNRETHEI-VALKRVRLDDDDEGVPSSALREICL 54 K + +GEG +G V A K++ + VA+K ++ DD E S + E+ + Sbjct: 35 DKLTLGKPLGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKMLK-DDATEKDLSDLVSEMEM 93 Query: 55 LKEL-KHKNIVRLHDVLHSDKKLTLVFEFCD-QDLKKYFDSCNGD--------------- 97 +K + KHKNI+ L D L ++ + +L++Y + Sbjct: 94 MKMIGKHKNIINLLGACTQDGPLYVIVAYASKGNLREYLRARRPPGMELSPDINRVPEEQ 153 Query: 98 LDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPV-- 155 + + + S +QL +G+ + S+ +HRDL +N+L+ N +K+ADFGLAR Sbjct: 154 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDFF 213 Query: 156 RCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRI 215 + + + + + P+ LF ++Y+ D+WS G + E+ G +PG V++ K + Sbjct: 214 KETTNGRLPVKWMAPEALFD-RVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLL 272 Query: 216 FRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNL 266 P +Y + VP T + L+++L Sbjct: 273 KEG----------HRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 313 >5TUR-A nrPDB Length = 404 Score = 190 bits (484), Expect = 5e-49, Method: Composition-based stats. Identities = 72/299 (24%), Positives = 122/299 (40%), Gaps = 48/299 (16%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVP----SSALREICLLKEL 58 +Y+ +G G +G+V+ + VA+K V D + + E+ LLK++ Sbjct: 128 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 187 Query: 59 KHKN--IVRLHDVLHSDKKLTLVFEFCD--QDLKKYFDSCNGDLDPEIVKSFLFQLLKGL 114 ++RL D L+ E + QDL + + G L E+ +SF +Q+L+ + Sbjct: 188 SSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFI-TERGALQEELARSFFWQVLEAV 246 Query: 115 GFCHSRNVLHRDLKPQNLLIN-RNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVL 173 CH+ VLHRD+K +N+LI+ GELKL DFG V Y+ T Y PP+ + Sbjct: 247 RHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV--YTDFDGTRVYSPPEWI 304 Query: 174 FGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKL 233 + + S +WS G + ++ P + + I R Sbjct: 305 RYHRYHGRSAAVWSLGILLYDMVCGDIPF-------EHDEEIIR---------------- 341 Query: 234 PDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 292 V ++++ + L++ L P R + EE HP+ D P Sbjct: 342 -------------GQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLP 387 >5O0Y-A nrPDB Length = 579 Score = 190 bits (483), Expect = 6e-49, Method: Composition-based stats. Identities = 67/293 (22%), Positives = 113/293 (38%), Gaps = 45/293 (15%) Query: 15 YGTVFKAKNRETHEIVALKRVRL-----DDDDEGVPSSALREICLLKELKHKNIVRLHDV 69 + V+KA + VA+K +L D+ E A RE + KEL H IV+L+D Sbjct: 297 FSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDY 356 Query: 70 LH-SDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN--VLHRD 126 V E+C+ + ++ + + + +S + Q++ L + + ++H D Sbjct: 357 FSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYD 416 Query: 127 LKPQNLLINRN---GELKLADFGLARAFGIP-------VRCYSAEVVTLWYRPPDVLFGA 176 LKP N+L+ GE+K+ DFGL++ + S T WY PP+ Sbjct: 417 LKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVG 476 Query: 177 K---LYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKL 233 K S +D+WS G IF + +P D L+ + TE Q+P Sbjct: 477 KEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQE--NTILKATEVQFPPK--- 531 Query: 234 PDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286 P + + ++ L RI ++ PY Sbjct: 532 -------------------PVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 565 >2OGV-A nrPDB Length = 317 Score = 190 bits (483), Expect = 6e-49, Method: Composition-based stats. Identities = 57/279 (20%), Positives = 112/279 (40%), Gaps = 31/279 (11%) Query: 5 EKLEKIGEGTYGTVFKAKNRETHEI-----VALKRVRLDDDDEGVPSSALREICLLKEL- 58 + + +G G +G V +A + VA+K ++ + + E+ ++ L Sbjct: 41 QFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLK-STAHADEKEALMSELKIMSHLG 99 Query: 59 KHKNIVRLHDVLHSDKKLTLVFEFC-DQDLKKYFDSC---------NGDLDPEIVKSFLF 108 +H+NIV L + ++ E+C DL + L+ + F Sbjct: 100 QHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEADLDKEDGRPLELRDLLHFSS 159 Query: 109 QLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVR---CYSAEVVTL 165 Q+ +G+ F S+N +HRD+ +N+L+ K+ DFGLAR +A + Sbjct: 160 QVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVK 219 Query: 166 WYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEE 225 W P+ +F +Y+ D+WS G + E+ + G +PG V+ + ++ + Sbjct: 220 W-MAPESIFDC-VYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVK-------- 269 Query: 226 QWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQ 264 P + P +Y + + P T + + Sbjct: 270 -DGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICS 307 >2PL0-A nrPDB Length = 289 Score = 190 bits (483), Expect = 7e-49, Method: Composition-based stats. Identities = 58/263 (22%), Positives = 116/263 (44%), Gaps = 13/263 (4%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 + + +E++G G +G V+ H VA+K ++ P + L E L+K+L+H+ Sbjct: 23 ETLKLVERLGAGQFGEVWMGYY-NGHTKVAVKSLKQGSMS---PDAFLAEANLMKQLQHQ 78 Query: 62 NIVRLHDVLHSDKKLTLVFEFCD-QDLKKYFDSCNG-DLDPEIVKSFLFQLLKGLGFCHS 119 +VRL+ V+ + + + ++ E+ + L + + +G L + Q+ +G+ F Sbjct: 79 RLVRLYAVV-TQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEE 137 Query: 120 RNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLW---YRPPDVLFGA 176 RN +HRDL+ N+L++ K+ADFGLAR Y+A + + P+ + Sbjct: 138 RNYIHRDLRAANILVSDTLSCKIADFGLARLI--EDNEYTAREGAKFPIKWTAPEAI-NY 194 Query: 177 KLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDY 236 ++ D+WS G + E+ GR +PG + ++ + R + P Sbjct: 195 GTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMR 254 Query: 237 KPYPMYPATTSLVNVVPKLNATG 259 + P + + + Sbjct: 255 LCWKERPEDRPTFDYLRSVLEDF 277 >6FEX-A nrPDB Length = 321 Score = 190 bits (482), Expect = 9e-49, Method: Composition-based stats. Identities = 65/313 (20%), Positives = 121/313 (38%), Gaps = 49/313 (15%) Query: 3 KYEKLEKIGEGTYGTVFKAK--------------NRETHE--IVALKRVRLDDDDEGVPS 46 + EK+GEG +G V + N +VA+K +R D + + Sbjct: 17 RLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILR-PDATKNARN 75 Query: 47 SALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCD-QDLKKYFDSCN---------- 95 L+E+ ++ LK NI+RL V D L ++ ++ + DL ++ + Sbjct: 76 DFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAP 135 Query: 96 --GDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAF-- 151 + ++ Q+ G+ + + N +HRDL +N L+ N +K+ADFG++R Sbjct: 136 GDPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYA 195 Query: 152 GIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAE--LANAGRPLFPGNDVD 209 G R V+ + + + + K ++T+ D+W+ G E + +P G D Sbjct: 196 GDYYRVQGRAVLPIRWMAWECILMGK-FTTASDVWAFGVTLWEVLMLCRAQPF--GQLTD 252 Query: 210 DQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKC 269 +Q+ I ++ P P +Y + + L Sbjct: 253 EQV--IENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQL------- 303 Query: 270 NPVQRISAEEALQ 282 R AE+AL Sbjct: 304 ---HRFLAEDALN 313 >4HZS-A nrPDB Length = 341 Score = 189 bits (481), Expect = 9e-49, Method: Composition-based stats. Identities = 65/279 (23%), Positives = 118/279 (42%), Gaps = 19/279 (6%) Query: 2 QKYEKLEKIGEGTYGTVFKAK-NRETHEIV--ALKRVRLDDDDE-GVPSSALREICLLKE 57 + LEK+G+G++G V + + + + + V A+K ++ D + +RE+ + Sbjct: 12 KDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHS 71 Query: 58 LKHKNIVRLHDVLHSDKKLTLVFEFCD-QDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGF 116 L H+N++RL+ V+ + + +V E L G + + Q+ +G+G+ Sbjct: 72 LDHRNLIRLYGVVLTP-PMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGY 130 Query: 117 CHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCY---SAEVVTLWYRPPDVL 173 S+ +HRDL +NLL+ +K+ DFGL RA Y V + P+ L Sbjct: 131 LESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESL 190 Query: 174 FGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKL 233 + +S + D W G E+ G+ + G + L +I + E+ P Sbjct: 191 -KTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDK-----EGERLPR---- 240 Query: 234 PDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPV 272 P+ P +Y P+ T L LL+ P Sbjct: 241 PEDCPQDIYNVMVQCWAHKPEDRPTFVALRDFLLEAQPT 279 >2W1I-A nrPDB Length = 326 Score = 189 bits (481), Expect = 9e-49, Method: Composition-based stats. Identities = 72/278 (25%), Positives = 118/278 (42%), Gaps = 28/278 (10%) Query: 5 EKLEKIGEGTYGTVFKAKNR----ETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 + L+++G+G +G+V + T E+VA+K++ E REI +LK L+H Sbjct: 44 KFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKL--QHSTEEHLRDFEREIEILKSLQH 101 Query: 61 KNIVRLHDVLHS--DKKLTLVFEFCD-QDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFC 117 NIV+ V +S + L L+ E+ L+ Y +D + + Q+ KG+ + Sbjct: 102 DNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYL 161 Query: 118 HSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYS----AEVVTLWYRPPDVL 173 ++ +HRDL +N+L+ +K+ DFGL + Y E WY P+ L Sbjct: 162 GTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWY-APESL 220 Query: 174 FGAKLYSTSIDMWSAGCIFAELANA----GRPLFP-----GNDVDDQLKRIFRLLGTPTE 224 +K +S + D+WS G + EL P GND Q+ + Sbjct: 221 TESK-FSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNN 279 Query: 225 EQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDL 262 + P PD P +Y T N + RDL Sbjct: 280 GRLPR----PDGCPDEIYMIMTECWNNNVNQRPSFRDL 313 >6BSD-A nrPDB Length = 876 Score = 189 bits (481), Expect = 1e-48, Method: Composition-based stats. Identities = 65/319 (20%), Positives = 121/319 (37%), Gaps = 55/319 (17%) Query: 3 KYEKLEKIGEGTYGTVFKAK--------------NRETHE--IVALKRVRLDDDDEGVPS 46 + EK+GEG +G V + N +VA+K +R D + + Sbjct: 572 RLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILR-PDATKNARN 630 Query: 47 SALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCD-QDLKKYFDSCN---------- 95 L+E+ ++ LK NI+RL V D L ++ ++ + DL ++ + Sbjct: 631 DFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAP 690 Query: 96 --------GDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGL 147 + ++ Q+ G+ + + N +HRDL +N L+ N +K+ADFG+ Sbjct: 691 GDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGM 750 Query: 148 ARAF--GIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAE--LANAGRPLF 203 +R G R V+ + + + + K ++T+ D+W+ G E + +P Sbjct: 751 SRNLYAGDYYRVQGRAVLPIRWMAWECILMGK-FTTASDVWAFGVTLWEVLMLCRAQPF- 808 Query: 204 PGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLL 263 G D+Q+ I ++ P P +Y + + L Sbjct: 809 -GQLTDEQV--IENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQL- 864 Query: 264 QNLLKCNPVQRISAEEALQ 282 R AE+AL Sbjct: 865 ---------HRFLAEDALN 874 >4LFI-A nrPDB Length = 374 Score = 189 bits (481), Expect = 1e-48, Method: Composition-based stats. Identities = 84/331 (25%), Positives = 153/331 (46%), Gaps = 49/331 (14%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVAL------------------------KRVRL 37 + YE K+G G Y VF+ ++ + + K Sbjct: 40 KDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPT 99 Query: 38 DDDDEGVPSSALREICLLKELK----------HKNIVRLHDVLHSD--KKLTLVFEFCDQ 85 + ++ +LK ++ H NI+ L D++ K LVFE+ D Sbjct: 100 TLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDN 159 Query: 86 DLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLIN-RNGELKLAD 144 F L ++ ++F+LLK L +CHS ++HRD+KP N++I+ +N +L+L D Sbjct: 160 ---VDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLID 216 Query: 145 FGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFP 204 +GLA + + + Y+ V + +++ P++L ++Y S+D+WS G + A + P F Sbjct: 217 WGLAEFYHVNME-YNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFH 275 Query: 205 GNDVDDQLKRIFRLLGTPTEEQWPSMTKLP------DYKPYPMYPATTSLVNVVPKLN-- 256 G DQL +I ++LGT E++ ++ D Y P + + L+ Sbjct: 276 GTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGN 335 Query: 257 ATGRDLLQNLLKCNPVQRISAEEALQHPYFS 287 DL+ NLL+ + +R++A+EA+ HP+F+ Sbjct: 336 DEIIDLIDNLLRYDHQERLTAKEAMGHPWFA 366 >3KUL-B nrPDB Length = 325 Score = 189 bits (481), Expect = 1e-48, Method: Composition-based stats. Identities = 55/285 (19%), Positives = 109/285 (38%), Gaps = 22/285 (7%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEI---VALKRVRLDDDDEGVPSSALREICLLKELK 59 + + IG G G V + R + VA+K ++ E L E ++ + Sbjct: 50 RIHIEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKAG-YTERQRRDFLSEASIMGQFD 108 Query: 60 HKNIVRLHDVLHSDKKLTLVFEFCD-QDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCH 118 H NI+RL V+ + +V E+ + L + + +G + L + G+ + Sbjct: 109 HPNIIRLEGVVTRGRLAMIVTEYMENGSLDTFLRTHDGQFTIMQLVGMLRGVGAGMRYLS 168 Query: 119 SRNVLHRDLKPQNLLINRNGELKLADFGLARAF-GIPVRCYSAEVV--TLWYRPPDVLFG 175 +HRDL +N+L++ N K++DFGL+R P Y+ + + P+ + Sbjct: 169 DLGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTAPEAI-A 227 Query: 176 AKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPD 235 + +S++ D+WS G + E+ G + D + + P P Sbjct: 228 FRTFSSASDVWSFGVVMWEVLAYGERPYWNMTNRDVISSVEEGYRLPAPMGCP------- 280 Query: 236 YKPYPMYPATTSLVNVVPKLNATGRDLLQNL--LKCNPVQ-RISA 277 + ++ + ++ L L +P R +A Sbjct: 281 ---HALHQLMLDCWHKDRAQRPRFSQIVSVLDALIRSPESLRATA 322 >5AMN-A nrPDB Length = 299 Score = 189 bits (481), Expect = 1e-48, Method: Composition-based stats. Identities = 64/284 (22%), Positives = 117/284 (41%), Gaps = 32/284 (11%) Query: 6 KLEKIGEGTYGTVFKA-----KNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 + +GEG +G V KA K R + VA+K ++ ++ L E +LK++ H Sbjct: 27 LGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLK-ENASPSELRDLLSEFNVLKQVNH 85 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCD-QDLKKYFDSCN---------GDLDPEIVKSFLFQL 110 ++++L+ D L L+ E+ L+ + L + SF +Q+ Sbjct: 86 PHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYPDERALTMGDLISFAWQI 145 Query: 111 LKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLW--YR 168 +G+ + ++HRDL +N+L+ ++K++DFGL+R + + Sbjct: 146 SQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWM 205 Query: 169 PPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWP 228 + LF +Y+T D+WS G + E+ G +PG +R+F LL T Sbjct: 206 AIESLFDH-IYTTQSDVWSFGVLLWEIVTLGGNPYPGIPP----ERLFNLLKTGHR---- 256 Query: 229 SMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDL---LQNLLKC 269 + PD MY P D+ L+ ++ Sbjct: 257 --MERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVK 298 >2HK5-A nrPDB Length = 270 Score = 189 bits (481), Expect = 1e-48, Method: Composition-based stats. Identities = 62/263 (23%), Positives = 115/263 (43%), Gaps = 13/263 (4%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 + + +K+G G +G V+ A + H VA+K ++ + L E ++K L+H Sbjct: 15 ESLKLEKKLGAGQFGEVWMATYNK-HTKVAVKTMKPGSMS---VEAFLAEANVMKTLQHD 70 Query: 62 NIVRLHDVLHSDKKLTLVFEFC-DQDLKKYFDSCNGDLDP-EIVKSFLFQLLKGLGFCHS 119 +V+LH V+ + + + ++ EF L + S G P + F Q+ +G+ F Sbjct: 71 KLVKLHAVV-TKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQ 129 Query: 120 RNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLW---YRPPDVLFGA 176 RN +HRDL+ N+L++ + K+ADFGLAR Y+A + + P+ + Sbjct: 130 RNYIHRDLRAANILVSASLVCKIADFGLARVI--EDNEYTAREGAKFPIKWTAPEAI-NF 186 Query: 177 KLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDY 236 ++ D+WS G + E+ GR +PG + ++ + R P E P Sbjct: 187 GSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMM 246 Query: 237 KPYPMYPATTSLVNVVPKLNATG 259 + + P + + Sbjct: 247 RCWKNRPEERPTFEYIQSVLDDF 269 >6DBN-A nrPDB Length = 316 Score = 189 bits (480), Expect = 1e-48, Method: Composition-based stats. Identities = 66/293 (22%), Positives = 122/293 (41%), Gaps = 29/293 (9%) Query: 2 QKY-EKLEKIGEGTYGTVFKAK----NRETHEIVALKRVRLDDDDEGVPSSALREICLLK 56 +++ +++ +GEG +G V + T E VA+K ++ + + +EI +L+ Sbjct: 34 KRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGG-NHIADLKKEIEILR 92 Query: 57 ELKHKNIVRLHDVLHSDKK--LTLVFEFC-DQDLKKYFDSCNGDLDPEIVKSFLFQLLKG 113 L H+NIV+ + D + L+ EF LK+Y ++ + + Q+ KG Sbjct: 93 NLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKG 152 Query: 114 LGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYS----AEVVTLWYRP 169 + + SR +HRDL +N+L+ ++K+ DFGL +A Y+ + WY Sbjct: 153 MDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWY-A 211 Query: 170 PDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPS 229 P+ L +K Y + D+WS G EL + + +++G PT Q Sbjct: 212 PECLMQSKFY-IASDVWSFGVTLHELLTYC------DSDSSPMALFLKMIG-PTHGQMTV 263 Query: 230 MTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQ 282 + K P P L++ + P R S + ++ Sbjct: 264 TRLVNTLKEGKRLP-------CPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIE 309 >3IO7-A nrPDB Length = 313 Score = 189 bits (480), Expect = 1e-48, Method: Composition-based stats. Identities = 72/278 (25%), Positives = 118/278 (42%), Gaps = 28/278 (10%) Query: 5 EKLEKIGEGTYGTVFKAKNR----ETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 + L+++G+G +G+V + T E+VA+K++ E REI +LK L+H Sbjct: 31 KFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKL--QHSTEEHLRDFEREIEILKSLQH 88 Query: 61 KNIVRLHDVLHS--DKKLTLVFEFCD-QDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFC 117 NIV+ V +S + L L+ E+ L+ Y +D + + Q+ KG+ + Sbjct: 89 DNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYL 148 Query: 118 HSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYS----AEVVTLWYRPPDVL 173 ++ +HRDL +N+L+ +K+ DFGL + Y E WY P+ L Sbjct: 149 GTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWY-APESL 207 Query: 174 FGAKLYSTSIDMWSAGCIFAELANA----GRPLFP-----GNDVDDQLKRIFRLLGTPTE 224 +K +S + D+WS G + EL P GND Q+ + Sbjct: 208 TESK-FSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNN 266 Query: 225 EQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDL 262 + P PD P +Y T N + RDL Sbjct: 267 GRLPR----PDGCPDEIYMIMTECWNNNVNQRPSFRDL 300 >3BEA-A nrPDB Length = 333 Score = 188 bits (479), Expect = 2e-48, Method: Composition-based stats. Identities = 58/283 (20%), Positives = 112/283 (39%), Gaps = 35/283 (12%) Query: 5 EKLEKIGEGTYGTVFKAKNRETHEI-----VALKRVRLDDDDEGVPSSALREICLLKEL- 58 + + +G G +G V +A + VA+K ++ + + E+ ++ L Sbjct: 49 QFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLK-STAHADEKEALMSELKIMSHLG 107 Query: 59 KHKNIVRLHDVLHSDKKLTLVFEFC-DQDLKKYFDS-------------CNGDLDPEIVK 104 +H+NIV L + ++ E+C DL + N L + Sbjct: 108 QHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKSRVLETDPAFAIANSTLSTRDLL 167 Query: 105 SFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVR---CYSAE 161 F Q+ +G+ F S+N +HRD+ +N+L+ K+ DFGLAR +A Sbjct: 168 HFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNAR 227 Query: 162 VVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGT 221 + W P+ +F +Y+ D+WS G + E+ + G +PG V+ + ++ + Sbjct: 228 LPVKW-MAPESIFDC-VYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVK---- 281 Query: 222 PTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQ 264 P + P +Y + + P T + + Sbjct: 282 -----DGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICS 319 >4KIK-B nrPDB Length = 677 Score = 188 bits (479), Expect = 2e-48, Method: Composition-based stats. Identities = 73/287 (25%), Positives = 122/287 (42%), Gaps = 25/287 (8%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 +E E++G G +G V + N+ET E +A+K+ R + L EI +++ L H N+ Sbjct: 21 WEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCL-EIQIMRRLTHPNV 79 Query: 64 VRLHDVLHSDKKL------TLVFEFC-DQDLKKYFDSCNG--DLDPEIVKSFLFQLLKGL 114 V DV + L L E+C DL+KY + L + + L + L Sbjct: 80 VAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASAL 139 Query: 115 GFCHSRNVLHRDLKPQNLLINRNGEL---KLADFGLARAFGIPVRCYSAEVVTLWYRPPD 171 + H ++HRDLKP+N+++ + + K+ D G A+ C ++ V TL Y P+ Sbjct: 140 RYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLC-TSFVGTLQYLAPE 198 Query: 172 VLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRL--LGTPTEEQWPS 229 +L K Y+ ++D WS G + E RP P ++ + + E Sbjct: 199 LLEQQK-YTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNG 257 Query: 230 MTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRIS 276 K PYP + + LQ +L +P QR + Sbjct: 258 TVKFSSSLPYPNNLNSVLAERLEKW--------LQLMLMWHPRQRGT 296 >3BGP-A nrPDB Length = 333 Score = 188 bits (479), Expect = 2e-48, Method: Composition-based stats. Identities = 72/299 (24%), Positives = 122/299 (40%), Gaps = 48/299 (16%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVP----SSALREICLLKEL 58 +Y+ +G G +G+V+ + VA+K V D + + E+ LLK++ Sbjct: 57 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 116 Query: 59 KHKN--IVRLHDVLHSDKKLTLVFEFCD--QDLKKYFDSCNGDLDPEIVKSFLFQLLKGL 114 ++RL D L+ E + QDL + + G L E+ +SF +Q+L+ + Sbjct: 117 SSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFI-TERGALQEELARSFFWQVLEAV 175 Query: 115 GFCHSRNVLHRDLKPQNLLIN-RNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVL 173 CH+ VLHRD+K +N+LI+ GELKL DFG V Y+ T Y PP+ + Sbjct: 176 RHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV--YTDFDGTRVYSPPEWI 233 Query: 174 FGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKL 233 + + S +WS G + ++ P + + I R Sbjct: 234 RYHRYHGRSAAVWSLGILLYDMVCGDIPF-------EHDEEIIR---------------- 270 Query: 234 PDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 292 V ++++ + L++ L P R + EE HP+ D P Sbjct: 271 -------------GQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLP 316 >5HIE-A nrPDB Length = 302 Score = 188 bits (478), Expect = 3e-48, Method: Composition-based stats. Identities = 54/272 (19%), Positives = 110/272 (40%), Gaps = 18/272 (6%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62 + ++IG G++GTV+K K VA+K + + E+ +L++ +H N Sbjct: 37 QITVGQRIGSGSFGTVYKGKWHGD---VAVKML-----TPQQLQAFKNEVGVLRKTRHVN 88 Query: 63 IVRLHDVLHSDKKLTLVFEFCDQD-LKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN 121 I+ + +L +V ++C+ L + + + Q +G+ + H+++ Sbjct: 89 ILLFMG-YSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKS 147 Query: 122 VLHRDLKPQNLLINRNGELKLADFGLARAFG--IPVRCYSAEVVTLWYRPPDVL--FGAK 177 ++HRDLK N+ ++ + +K+ DFGLA + ++ + P+V+ Sbjct: 148 IIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKN 207 Query: 178 LYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYK 237 YS D+++ G + EL P N+ D + + R G + + + P Sbjct: 208 PYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGR--GYLSPDLSKVRSNCPKAM 265 Query: 238 PYPMYPATTSLVNVVPKLNA--TGRDLLQNLL 267 M + P +LL L Sbjct: 266 KRLMAECLKKKRDERPLFPQILASIELLARSL 297 >1U54-B nrPDB Length = 291 Score = 188 bits (477), Expect = 3e-48, Method: Composition-based stats. Identities = 65/279 (23%), Positives = 118/279 (42%), Gaps = 19/279 (6%) Query: 2 QKYEKLEKIGEGTYGTVFKAK-NRETHEIV--ALKRVRLDDDDE-GVPSSALREICLLKE 57 + LEK+G+G++G V + + + + + V A+K ++ D + +RE+ + Sbjct: 18 KDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHS 77 Query: 58 LKHKNIVRLHDVLHSDKKLTLVFEFCD-QDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGF 116 L H+N++RL+ V+ + + +V E L G + + Q+ +G+G+ Sbjct: 78 LDHRNLIRLYGVVLTP-PMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGY 136 Query: 117 CHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCY---SAEVVTLWYRPPDVL 173 S+ +HRDL +NLL+ +K+ DFGL RA Y V + P+ L Sbjct: 137 LESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESL 196 Query: 174 FGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKL 233 + +S + D W G E+ G+ + G + L +I + E+ P Sbjct: 197 -KTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDK-----EGERLPR---- 246 Query: 234 PDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPV 272 P+ P +Y P+ T L LL+ P Sbjct: 247 PEDCPQDIYNVMVQCWAHKPEDRPTFVALRDFLLEAQPT 285 >3DLS-A nrPDB Length = 335 Score = 187 bits (476), Expect = 4e-48, Method: Composition-based stats. Identities = 64/294 (21%), Positives = 117/294 (39%), Gaps = 44/294 (14%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALR------EICLL 55 QKY + +G G +G V+ A ++E ++ V +K ++ + E + EI +L Sbjct: 24 QKYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAIL 83 Query: 56 KELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKY-FDSCNGDLDPEIVKSFLFQLLKGL 114 ++H NI+++ D+ + LV E L + F + LD + QL+ + Sbjct: 84 SRVEHANIIKVLDIFENQGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASYIFRQLVSAV 143 Query: 115 GFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLF 174 G+ ++++HRD+K +N++I + +KL DFG A Y+ T+ Y P+VL Sbjct: 144 GYLRLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYT-FCGTIEYCAPEVLM 202 Query: 175 GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLP 234 G ++MWS G L P EE + P Sbjct: 203 GNPYRGPELEMWSLGVTLYTLVFEENPF------------------CELEETVEAAIHPP 244 Query: 235 DYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288 ++ L+ LL+ P +R + E+ + P+ + Sbjct: 245 YL------------------VSKELMSLVSGLLQPVPERRTTLEKLVTDPWVTQ 280 >4CRS-A nrPDB Length = 341 Score = 187 bits (476), Expect = 4e-48, Method: Composition-based stats. Identities = 66/297 (22%), Positives = 120/297 (40%), Gaps = 43/297 (14%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDD----DDEGVPSSALREICLLK 56 +Q + + G +G V A+ + T+E+ A+K ++ D D+ R + Sbjct: 11 LQDFRCCAVLLRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVN 70 Query: 57 ELKHKNIVRLHDVLHSDKKLTLVFEFC-DQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLG 115 ++H +V L + + + V E+ DL + + ++ GL Sbjct: 71 SVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHI--HTDVFSEPRAVFYAACVVLGLQ 128 Query: 116 FCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFG 175 + H +++RDLK NLL++ G +K+ADFGL + S T + P+VL Sbjct: 129 YLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVL-T 187 Query: 176 AKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPD 235 Y+ ++D W G + E+ P FPG+D ++ I D Sbjct: 188 ETSYTRAVDWWGLGVLIYEMLVGESP-FPGDDEEEVFDSIVN-----------------D 229 Query: 236 YKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRIS-----AEEALQHPYFS 287 YP + L+ +++ LL+ NP +R+ AE+ +HP+F Sbjct: 230 EVRYPRF------------LSTEAISIMRRLLRRNPERRLGASEKDAEDVKKHPFFR 274 >3KRL-A nrPDB Length = 335 Score = 187 bits (476), Expect = 5e-48, Method: Composition-based stats. Identities = 57/285 (20%), Positives = 111/285 (38%), Gaps = 37/285 (12%) Query: 5 EKLEKIGEGTYGTVFKAKNRETHEI-----VALKRVRLDDDDEGVPSSALREICLLKEL- 58 + + +G G +G V +A + VA+K ++ + + E+ ++ L Sbjct: 49 QFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLK-STAHADEKEALMSELKIMSHLG 107 Query: 59 KHKNIVRLHDVLHSDKKLTLVFEFC-DQDLKKYFDSCNGD---------------LDPEI 102 +H+NIV L + ++ E+C DL + L Sbjct: 108 QHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKRPPGLEYSYNPSHNPEEQLSSRD 167 Query: 103 VKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVR---CYS 159 + F Q+ +G+ F S+N +HRD+ +N+L+ K+ DFGLAR + Sbjct: 168 LLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGN 227 Query: 160 AEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLL 219 A + W P+ +F +Y+ D+WS G + E+ + G +PG V+ + ++ + Sbjct: 228 ARLPVKW-MAPESIFDC-VYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVK-- 283 Query: 220 GTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQ 264 P + P +Y + + P T + + Sbjct: 284 -------DGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICS 321 >4RC3-A nrPDB Length = 289 Score = 187 bits (475), Expect = 5e-48, Method: Composition-based stats. Identities = 72/299 (24%), Positives = 122/299 (40%), Gaps = 48/299 (16%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVP----SSALREICLLKEL 58 +Y+ +G G +G+V+ + VA+K V D + + E+ LLK++ Sbjct: 13 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 72 Query: 59 KHKN--IVRLHDVLHSDKKLTLVFEFCD--QDLKKYFDSCNGDLDPEIVKSFLFQLLKGL 114 ++RL D L+ E + QDL + + G L E+ +SF +Q+L+ + Sbjct: 73 SSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFI-TERGALQEELARSFFWQVLEAV 131 Query: 115 GFCHSRNVLHRDLKPQNLLIN-RNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVL 173 CH+ VLHRD+K +N+LI+ GELKL DFG V Y+ T Y PP+ + Sbjct: 132 RHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV--YTDFDGTRVYSPPEWI 189 Query: 174 FGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKL 233 + + S +WS G + ++ P + + I R Sbjct: 190 RYHRYHGRSAAVWSLGILLYDMVCGDIPF-------EHDEEIIR---------------- 226 Query: 234 PDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 292 V ++++ + L++ L P R + EE HP+ D P Sbjct: 227 -------------GQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLP 272 >1U59-A nrPDB Length = 287 Score = 187 bits (475), Expect = 5e-48, Method: Composition-based stats. Identities = 59/240 (24%), Positives = 110/240 (45%), Gaps = 14/240 (5%) Query: 9 KIGEGTYGTVFKA--KNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRL 66 ++G G +G+V + + R+ VA+K ++ + +RE ++ +L + IVRL Sbjct: 17 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEK-ADTEEMMREAQIMHQLDNPYIVRL 75 Query: 67 HDVLHSDKKLTLVFEFCDQD-LKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHR 125 V ++ L LV E L K+ ++ V L Q+ G+ + +N +HR Sbjct: 76 IGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHR 134 Query: 126 DLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLW---YRPPDVLFGAKLYSTS 182 DL +N+L+ K++DFGL++A G Y+A W + P+ + + +S+ Sbjct: 135 DLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI-NFRKFSSR 193 Query: 183 IDMWSAGCIFAELANAGRPLF---PGNDVDDQLKRIFRLLGTP--TEEQWPSMTKLPDYK 237 D+WS G E + G+ + G +V +++ R+ P E + M+ YK Sbjct: 194 SDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYK 253 >1AD5-A nrPDB Length = 438 Score = 186 bits (474), Expect = 6e-48, Method: Composition-based stats. Identities = 64/260 (24%), Positives = 115/260 (44%), Gaps = 17/260 (6%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 + + +K+G G +G V+ A + H VA+K ++ + L E ++K L+H Sbjct: 182 ESLKLEKKLGAGQFGEVWMATYNK-HTKVAVKTMKPGSMS---VEAFLAEANVMKTLQHD 237 Query: 62 NIVRLHDVLHSDKKLTLVFEFC-DQDLKKYFDSCNGDLDP-EIVKSFLFQLLKGLGFCHS 119 +V+LH V+ + + + ++ EF L + S G P + F Q+ +G+ F Sbjct: 238 KLVKLHAVV-TKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQ 296 Query: 120 RNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLY 179 RN +HRDL+ N+L++ + K+ADFGLAR A+ W P + FG+ + Sbjct: 297 RNYIHRDLRAANILVSASLVCKIADFGLAR--------VGAKFPIKWTAPEAINFGS--F 346 Query: 180 STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPY 239 + D+WS G + E+ GR +PG + ++ + R P E P + + Sbjct: 347 TIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCW 406 Query: 240 PMYPATTSLVNVVPKLNATG 259 P + + Sbjct: 407 KNRPEERPTFEYIQSVLDDF 426 >4M7I-A nrPDB Length = 299 Score = 186 bits (474), Expect = 8e-48, Method: Composition-based stats. Identities = 71/319 (22%), Positives = 132/319 (41%), Gaps = 60/319 (18%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 + +E ++ +G G +G VF+AKN+ A+KR+RL + E +RE+ L +L+H Sbjct: 4 LTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPN-RELAREKVMREVKALAKLEH 62 Query: 61 KNIVRLHDVLHSDK------------KLTLVFEFCDQDLKKYFDSCNGDLDPEIV---KS 105 IVR + L + + C ++ K + + ++ Sbjct: 63 PGIVRYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLH 122 Query: 106 FLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRC-------- 157 Q+ + + F HS+ ++HRDLKP N+ + +K+ DFGL A Sbjct: 123 IFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMP 182 Query: 158 ----YSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLK 213 ++ +V T Y P+ + G YS +D++S G I EL P Q++ Sbjct: 183 AYARHTGQVGTKLYMSPEQIHGNS-YSHKVDIFSLGLILFELL---YPF------STQME 232 Query: 214 RIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQ 273 R+ ++T + + K P++ V+ +Q++L +P++ Sbjct: 233 RVR------------TLTDVRNLKFPPLFTQKYPCEYVM----------VQDMLSPSPME 270 Query: 274 RISAEEALQHPYFSDFCPP 292 R A +++ F D P Sbjct: 271 RPEAINIIENAVFEDLDFP 289 >2OZO-A nrPDB Length = 613 Score = 186 bits (474), Expect = 8e-48, Method: Composition-based stats. Identities = 58/240 (24%), Positives = 110/240 (45%), Gaps = 14/240 (5%) Query: 9 KIGEGTYGTVFKA--KNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRL 66 ++G G +G+V + + R+ VA+K ++ + +RE ++ +L + IVRL Sbjct: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEK-ADTEEMMREAQIMHQLDNPYIVRL 401 Query: 67 HDVLHSDKKLTLVFEFCDQD-LKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHR 125 V ++ L LV E L K+ ++ V L Q+ G+ + +N +HR Sbjct: 402 IGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHR 460 Query: 126 DLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLW---YRPPDVLFGAKLYSTS 182 +L +N+L+ K++DFGL++A G Y+A W + P+ + + +S+ Sbjct: 461 NLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI-NFRKFSSR 519 Query: 183 IDMWSAGCIFAELANAGRPLF---PGNDVDDQLKRIFRLLGTP--TEEQWPSMTKLPDYK 237 D+WS G E + G+ + G +V +++ R+ P E + M+ YK Sbjct: 520 SDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYK 579 >4H1J-A nrPDB Length = 293 Score = 186 bits (473), Expect = 9e-48, Method: Composition-based stats. Identities = 57/265 (21%), Positives = 113/265 (42%), Gaps = 14/265 (5%) Query: 8 EKIGEGTYGTVFKAK---NRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIV 64 +GEG +G V++ ++ VA+K + D + + E ++K L H +IV Sbjct: 30 RILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDN-KEKFMSEAVIMKNLDHPHIV 88 Query: 65 RLHDVLHSDKKLTLVFEFCD-QDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVL 123 +L ++ + ++ E +L Y + L + + Q+ K + + S N + Sbjct: 89 KLIGIIEEEPT-WIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINCV 147 Query: 124 HRDLKPQNLLINRNGELKLADFGLARAF-GIPVRCYSAEVVTLWYRPPDVLFGAKLYSTS 182 HRD+ +N+L+ +KL DFGL+R S + + + P+ + + ++T+ Sbjct: 148 HRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPESI-NFRRFTTA 206 Query: 183 IDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPS-----MTKLPDYK 237 D+W E+ + G+ F + D + + + P + P MT+ DY Sbjct: 207 SDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYD 266 Query: 238 PYPMYPATTSLVNVVPKLNATGRDL 262 P P T LV + + +D+ Sbjct: 267 PSDR-PRFTELVCSLSDVYQMEKDI 290 >5HLW-A nrPDB Length = 299 Score = 186 bits (473), Expect = 1e-47, Method: Composition-based stats. Identities = 64/271 (23%), Positives = 115/271 (42%), Gaps = 27/271 (9%) Query: 8 EKIGEGTYGTVFKAK---NRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIV 64 E IG G +G V+ N A+K + D G S L E ++K+ H N++ Sbjct: 26 EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLN-RITDIGEVSQFLTEGIIMKDFSHPNVL 84 Query: 65 RLHDVL-HSDKKLTLVFEFCD-QDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNV 122 L + S+ +V + DL+ + + + + + F Q+ KG+ + S+ Sbjct: 85 SLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKF 144 Query: 123 LHRDLKPQNLLINRNGELKLADFGLARAFGI----PVRCYSAEVVTLWYRPPDVLFGAKL 178 +HRDL +N +++ +K+ADFGLAR V + + + + + L K Sbjct: 145 VHRDLAARNCMLDEKFTVKVADFGLARDMHDKEYYSVHNKTGAKLPVKWMALESLQTQK- 203 Query: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQ---LKRIFRLLGTPTEEQWPSMTKLPD 235 ++T D+WS G + EL G P +P + D L + RLL P+ Sbjct: 204 FTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQ-------------PE 250 Query: 236 YKPYPMYPATTSLVNVVPKLNATGRDLLQNL 266 Y P P+Y + ++ + +L+ + Sbjct: 251 YCPDPLYEVMLKCWHPKAEMRPSFSELVSRI 281 >3C1X-A nrPDB Length = 373 Score = 186 bits (472), Expect = 1e-47, Method: Composition-based stats. Identities = 65/271 (23%), Positives = 115/271 (42%), Gaps = 27/271 (9%) Query: 8 EKIGEGTYGTVFKAK---NRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIV 64 E IG G +G V+ N A+K + D G S L E ++K+ H N++ Sbjct: 95 EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLN-RITDIGEVSQFLTEGIIMKDFSHPNVL 153 Query: 65 RLHDVL-HSDKKLTLVFEFCD-QDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNV 122 L + S+ +V + DL+ + + + + + F Q+ KG+ F S+ Sbjct: 154 SLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKFLASKKF 213 Query: 123 LHRDLKPQNLLINRNGELKLADFGLARAFG----IPVRCYSAEVVTLWYRPPDVLFGAKL 178 +HRDL +N +++ +K+ADFGLAR V + + + + + L K Sbjct: 214 VHRDLAARNCMLDEKFTVKVADFGLARDMYDKEFDSVHNKTGAKLPVKWMALESLQTQK- 272 Query: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQ---LKRIFRLLGTPTEEQWPSMTKLPD 235 ++T D+WS G + EL G P +P + D L + RLL P+ Sbjct: 273 FTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQ-------------PE 319 Query: 236 YKPYPMYPATTSLVNVVPKLNATGRDLLQNL 266 Y P P+Y + ++ + +L+ + Sbjct: 320 YCPDPLYEVMLKCWHPKAEMRPSFSELVSRI 350 >2X7G-A nrPDB Length = 389 Score = 185 bits (470), Expect = 2e-47, Method: Composition-based stats. Identities = 85/364 (23%), Positives = 142/364 (39%), Gaps = 86/364 (23%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62 +Y + K+G G + TV+ + + VA+K V+ + +AL EI LLK ++ + Sbjct: 32 RYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVK---SAQHYTETALDEIKLLKCVRESD 88 Query: 63 --------IVRLHDVLH----SDKKLTLVFEFCDQDLKKYFDSCN-GDLDPEIVKSFLFQ 109 +V+L D + + +VFE L K+ N L VKS + Q Sbjct: 89 PSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQ 148 Query: 110 LLKGLGFCHSR-NVLHRDLKPQNLLI---------------------------------- 134 +L+GL + HS+ ++H D+KP+N+L+ Sbjct: 149 VLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAVSTAP 208 Query: 135 -------------NRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYST 181 +K+AD G A + ++ ++ T YR +VL GA YST Sbjct: 209 AADLLVNPLDPRNADKIRVKIADLGNACWVH---KHFTEDIQTRQYRSIEVLIGA-GYST 264 Query: 182 SIDMWSAGCIFAELANAGRPLFPGNDVD-----DQLKRIFRLLGTPTEE----------- 225 D+WS C+ ELA P + D D + I LLG+ Sbjct: 265 PADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREF 324 Query: 226 --QWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQH 283 + + + KP+ ++ + A D L +L+ P +R SA E L+H Sbjct: 325 FNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRH 384 Query: 284 PYFS 287 P+ + Sbjct: 385 PWLN 388 >1FVR-A nrPDB Length = 327 Score = 185 bits (470), Expect = 2e-47, Method: Composition-based stats. Identities = 57/299 (19%), Positives = 112/299 (37%), Gaps = 50/299 (16%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIV--ALKRVRLDDDDEGVPSSALREICLLKEL- 58 + + IGEG +G V KA+ ++ + A+KR++ + + E+ +L +L Sbjct: 25 NDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMK-EYASKDDHRDFAGELEVLCKLG 83 Query: 59 KHKNIVRLHDVLHSDKKLTLVFEFCD-QDLKKYFDSCN---------------GDLDPEI 102 H NI+ L L L E+ +L + L + Sbjct: 84 HHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQ 143 Query: 103 VKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEV 162 + F + +G+ + + +HRDL +N+L+ N K+ADFGL+R + V+ + Sbjct: 144 LLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRL 203 Query: 163 VTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTP 222 W + L +Y+T+ D+WS G + E+ + G + G + +++ + Sbjct: 204 PVRW-MAIESL-NYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLE 261 Query: 223 TEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEAL 281 + DL++ + P +R S + L Sbjct: 262 KPLNC----------------------------DDEVYDLMRQCWREKPYERPSFAQIL 292 >1LUF-A nrPDB Length = 343 Score = 185 bits (469), Expect = 2e-47, Method: Composition-based stats. Identities = 63/296 (21%), Positives = 122/296 (41%), Gaps = 44/296 (14%) Query: 5 EKLEKIGEGTYGTVFKAKN-----RETHEIVALKRVRLDDDDEGVPSSALREICLLKELK 59 E + IGEG +G VF+A+ E +VA+K ++ ++ + + RE L+ E Sbjct: 50 EYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLK-EEASADMQADFQREAALMAEFD 108 Query: 60 HKNIVRLHDVLHSDKKLTLVFEFCD-QDLKKYFDSCNG---------------------- 96 + NIV+L V K + L+FE+ DL ++ S + Sbjct: 109 NPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRARVSSPGP 168 Query: 97 -DLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAF--GI 153 L Q+ G+ + R +HRDL +N L+ N +K+ADFGL+R Sbjct: 169 PPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSAD 228 Query: 154 PVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLK 213 + + + + + PP+ +F + Y+T D+W+ G + E+ + G + G ++ + Sbjct: 229 YYKADGNDAIPIRWMPPESIFYNR-YTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIY 287 Query: 214 RIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKC 269 + ++ P+ P +Y + +P + + +L+ Sbjct: 288 YVRD----------GNILACPENCPLELYNLMRLCWSKLPADRPSFCS-IHRILQR 332 >5X5O-A nrPDB Length = 310 Score = 185 bits (469), Expect = 2e-47, Method: Composition-based stats. Identities = 56/284 (19%), Positives = 112/284 (39%), Gaps = 46/284 (16%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 + E G G++G+V++AK + VA+K++ +E +L L H+ Sbjct: 15 DDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLK----------IEKEAEILSVLSHR 64 Query: 62 NIVRLHDVLHSDKKLTLVFEFCD-QDLKKYFDSCNGD-LDPEIVKSFLFQLLKGLGFCHS 119 NI++ + V+ +V E+ L Y +S + +D + + ++ + KG+ + H Sbjct: 65 NIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHM 124 Query: 120 R---NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGA 176 V+HRDLK +N++I +G LK+ DFG +R + V T + P+V+ Sbjct: 125 EAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHM--SLVGTFPWMAPEVIQSL 182 Query: 177 KLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDY 236 + S + D +S G + E+ P L Sbjct: 183 PV-SETCDTYSYGVVLWEMLTREVPF----------------------------KGLEGL 213 Query: 237 KPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEA 280 + + + + + +LL + + +R S ++ Sbjct: 214 QVAWLVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQI 257 >4WUA-A nrPDB Length = 401 Score = 185 bits (469), Expect = 3e-47, Method: Composition-based stats. Identities = 80/366 (21%), Positives = 146/366 (39%), Gaps = 88/366 (24%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62 +Y + K+G G + TV+ + + + + VA+K V+ E +AL EI LLK +++ + Sbjct: 42 RYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVK---SAEHYTETALDEIRLLKSVRNSD 98 Query: 63 --------IVRLHDVLH----SDKKLTLVFEFCDQDLKKYFDSCN-GDLDPEIVKSFLFQ 109 +V+L D + + +VFE L K+ N L VK + Q Sbjct: 99 PNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQ 158 Query: 110 LLKGLGFCHSR-NVLHRDLKPQNLLIN--------------------------------- 135 +L+GL + H++ ++H D+KP+N+L++ Sbjct: 159 VLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVSTAP 218 Query: 136 ----------------RNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLY 179 ++K+AD G A + ++ ++ T YR +VL G+ Y Sbjct: 219 ATAGNFLVNPLEPKNAEKLKVKIADLGNACWVH---KHFTEDIQTRQYRSLEVLIGS-GY 274 Query: 180 STSIDMWSAGCIFAELANAGRPLFPGNDV-----DDQLKRIFRLLGTPTEE--------- 225 +T D+WS C+ ELA P + +D + I LLG + Sbjct: 275 NTPADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSK 334 Query: 226 ----QWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEAL 281 + + + KP+ ++ + A D L +L+ P +R +A E L Sbjct: 335 EFFTKKGDLKHITKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATAAECL 394 Query: 282 QHPYFS 287 +HP+ + Sbjct: 395 RHPWLN 400 >4R7H-A nrPDB Length = 343 Score = 185 bits (469), Expect = 3e-47, Method: Composition-based stats. Identities = 58/296 (19%), Positives = 116/296 (39%), Gaps = 45/296 (15%) Query: 5 EKLEKIGEGTYGTVFKAKNRETHEI-----VALKRVRLDDDDEGVPSSALREICLLKEL- 58 + + +G G +G V +A + VA+K ++ + + E+ ++ L Sbjct: 53 QFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLK-STAHADEKEALMSELKIMSHLG 111 Query: 59 KHKNIVRLHDVLHSDKKLTLVFEFCD-QDLKKYFDSC----------------------N 95 +H+NIV L + ++ E+C DL + Sbjct: 112 QHENIVNLLGACTHGGPVLVITEYCTYGDLLNFLRRKAEAMLGPSLSPGQDPEGLDKEDG 171 Query: 96 GDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPV 155 L+ + F Q+ +G+ F S+N +HRD+ +N+L+ K+ DFGLAR Sbjct: 172 RPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDS 231 Query: 156 R---CYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQL 212 +A + W P+ +F + +Y+ D+WS G + E+ + G +PG V+ + Sbjct: 232 NYIVKGNARLPVKW-MAPESIFDS-VYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKF 289 Query: 213 KRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLK 268 ++ + P + P +Y + + P T + + + L+ Sbjct: 290 YKLVK---------DGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQ-ITSFLQ 335 >5FM2-A nrPDB Length = 355 Score = 185 bits (469), Expect = 3e-47, Method: Composition-based stats. Identities = 64/298 (21%), Positives = 117/298 (39%), Gaps = 46/298 (15%) Query: 6 KLEKIGEGTYGTVFKA-----KNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 + +GEG +G V KA K R + VA+K ++ ++ L E +LK++ H Sbjct: 68 LGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLK-ENASPSELRDLLSEFNVLKQVNH 126 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCD-QDLKKYFDSCN-----------------------G 96 ++++L+ D L L+ E+ L+ + Sbjct: 127 PHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDER 186 Query: 97 DLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVR 156 L + SF +Q+ +G+ + ++HRDL +N+L+ ++K++DFGL+R Sbjct: 187 ALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDS 246 Query: 157 CYSAEVVTLW--YRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKR 214 + + + LF +Y+T D+WS G + E+ G +PG +R Sbjct: 247 YVKRSQGRIPVKWMAIESLFDH-IYTTQSDVWSFGVLLWEIVTLGGNPYPGIPP----ER 301 Query: 215 IFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDL---LQNLLKC 269 +F LL T + PD MY P D+ L+ ++ Sbjct: 302 LFNLLKTGHR------MERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVK 353 >5VD3-A nrPDB Length = 311 Score = 184 bits (468), Expect = 4e-47, Method: Composition-based stats. Identities = 70/288 (24%), Positives = 118/288 (40%), Gaps = 35/288 (12%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKEL-KH 60 Q +++L ++G G+YG VFK +++E + A+KR + L E+ +++ +H Sbjct: 57 QSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQH 116 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 VRL L L E C L+++ ++ L V +L L L HS+ Sbjct: 117 PCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQ 176 Query: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYS 180 ++H D+KP N+ + G KL DFGL G + Y P++L G+ Y Sbjct: 177 GLVHLDVKPANIFLGPRGRCKLGDFGLLVELG-TAGAGEVQEGDPRYMAPELLQGS--YG 233 Query: 181 TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYP 240 T+ D++S G E+A G + QL++ + P E Sbjct: 234 TAADVFSLGLTILEVACNMELP-HGGEGWQQLRQGY----LPPE---------------- 272 Query: 241 MYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288 L++ R +L +L+ +P R +AE L P Sbjct: 273 ----------FTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQ 310 >2JD5-A nrPDB Length = 373 Score = 184 bits (467), Expect = 4e-47, Method: Composition-based stats. Identities = 81/327 (24%), Positives = 132/327 (40%), Gaps = 48/327 (14%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK- 61 +Y + K+G G + TV+ AK+ + VA+K VR D+ +A EI LL+ + Sbjct: 20 RYILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVR---GDKVYTEAAEDEIKLLQRVNDAD 76 Query: 62 ----------NIVRLHDVLHSDK----KLTLVFEFCDQDLKKYFDSC-NGDLDPEIVKSF 106 +I++L D + + +VFE ++L + + VK Sbjct: 77 NTKEDSMGANHILKLLDHFNHKGPNGVHVVMVFEVLGENLLALIKKYEHRGIPLIYVKQI 136 Query: 107 LFQLLKGLGFCHSR-NVLHRDLKPQNLLIN-----RNG-ELKLADFGLARAFGIPVRCYS 159 QLL GL + H R ++H D+KP+N+L+ N ++K+AD G A + Y+ Sbjct: 137 SKQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNACWYD---EHYT 193 Query: 160 AEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGN-----DVDDQLKR 214 + T YR P+VL GA + D+WS C+ EL P DD + + Sbjct: 194 NSIQTREYRSPEVLLGA-PWGCGADIWSTACLIFELITGDFLFEPDEGHSYTKDDDHIAQ 252 Query: 215 IFRLLGTPTE-------------EQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRD 261 I LLG + + K +P+ T D Sbjct: 253 IIELLGELPSYLLRNGKYTRTFFNSRGLLRNISKLKFWPLEDVLTEKYKFSKDEAKEISD 312 Query: 262 LLQNLLKCNPVQRISAEEALQHPYFSD 288 L +L+ +P +R A + HP+ D Sbjct: 313 FLSPMLQLDPRKRADAGGLVNHPWLKD 339 >3I81-A nrPDB Length = 315 Score = 183 bits (466), Expect = 6e-47, Method: Composition-based stats. Identities = 50/282 (17%), Positives = 111/282 (39%), Gaps = 29/282 (10%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHE-----IVALKRVRLDDDDEGVPSSALREICLLK 56 +K ++G+G++G V++ + + VA+K V + L E ++K Sbjct: 18 EKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVN-EAASMRERIEFLNEASVMK 76 Query: 57 ELKHKNIVRLHDVLHSDKKLTLVFEFC-DQDLKKYFDSCNGDLD---------PEIVKSF 106 E ++VRL V+ + ++ E DLK Y S +++ + Sbjct: 77 EFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQM 136 Query: 107 LFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVV--T 164 ++ G+ + ++ +HRDL +N ++ + +K+ DFG+ R Sbjct: 137 AGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLP 196 Query: 165 LWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTE 224 + + P+ L +++T D+WS G + E+A + G + L+ + Sbjct: 197 VRWMSPESLKDG-VFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVME------- 248 Query: 225 EQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNL 266 + PD P ++ PK+ + +++ ++ Sbjct: 249 ---GGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSI 287 >4HVI-A nrPDB Length = 314 Score = 183 bits (465), Expect = 7e-47, Method: Composition-based stats. Identities = 65/283 (22%), Positives = 116/283 (40%), Gaps = 29/283 (10%) Query: 5 EKLEKIGEGTYGTVFKAKNR----ETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 + + ++G+G +G+V + T +VA+K+++ D+ REI +LK L Sbjct: 13 KYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQ--QRDFQREIQILKALHS 70 Query: 61 KNIVRLHDVLHSDKK--LTLVFEFCDQD-LKKYFDSCNGDLDPEIVKSFLFQLLKGLGFC 117 IV+ V + + L LV E+ L+ + LD + + Q+ KG+ + Sbjct: 71 DFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYL 130 Query: 118 HSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCY----SAEVVTLWYRPPDVL 173 SR +HRDL +N+L+ +K+ADFGLA+ + Y + WY P+ L Sbjct: 131 GSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWY-APESL 189 Query: 174 FGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKL 233 ++S D+WS G + EL + + L+ + P + + + Sbjct: 190 -SDNIFSRQSDVWSFGVVLYELFTYCDK--SCSPSAEFLRMMGSERDVPALSRLLELLEE 246 Query: 234 PDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRIS 276 P P P A +L++ +P R S Sbjct: 247 GQRLPAP------------PACPAEVHELMKLCWAPSPQDRPS 277 >4YFF-A nrPDB Length = 311 Score = 183 bits (465), Expect = 8e-47, Method: Composition-based stats. Identities = 51/253 (20%), Positives = 99/253 (39%), Gaps = 8/253 (3%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDD-DEGVPSSALREICLLKELK 59 + + E E IG G++G V+K + R ++IVA+KR R + + RE+ +L +L Sbjct: 41 LSEIEFHEIIGSGSFGKVYKGRCR--NKIVAIKRYRANTYCSKSDVDMFCREVSILCQLN 98 Query: 60 HKNIVRLHDVLHSDK-KLTLVFEFCDQD-LKKYFDSCNGDLDPEIVKSFLFQLLKGLGFC 117 H +++ +D + +V ++ L LD + + KG+ + Sbjct: 99 HPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYL 158 Query: 118 H--SRNVLHRDLKPQNLLINRNGELKLADFGLARAF-GIPVRCYSAEVVTLWYRPPDVLF 174 H ++ ++HRDL N+L+ +G +ADFG +R + + + L + P+V Sbjct: 159 HNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFT 218 Query: 175 GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLP 234 Y+ D++S E+ P + + P P Sbjct: 219 QCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPISSL 278 Query: 235 DYKPYPMYPATTS 247 + + P Sbjct: 279 LIRGWNACPEGRP 291 >3QA8-A nrPDB Length = 676 Score = 182 bits (462), Expect = 2e-46, Method: Composition-based stats. Identities = 62/214 (28%), Positives = 105/214 (49%), Gaps = 15/214 (7%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 +E E++G G +G V + +++T E VA+K+ R + + L EI ++K+L H N+ Sbjct: 16 WEMKERLGTGGFGYVLRWIHQDTGEQVAIKQCRQELSPKNRERWCL-EIQIMKKLNHPNV 74 Query: 64 VRLHDVLHSDKKL------TLVFEFCDQ-DLKKYFDSCNG--DLDPEIVKSFLFQLLKGL 114 V +V +KL L E+C+ DL+KY + L +++ L + L Sbjct: 75 VSAREVPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGPIRTLLSDISSAL 134 Query: 115 GFCHSRNVLHRDLKPQNLLINRNGEL---KLADFGLARAFGIPVRCYSAEVVTLWYRPPD 171 + H ++HRDLKP+N+++ + K+ D G A+ C + V TL Y P+ Sbjct: 135 RYLHENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQGELC-TEFVGTLQYLAPE 193 Query: 172 VLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPG 205 +L K Y+ ++D WS G + E RP P Sbjct: 194 LLEQKK-YTVTVDYWSFGTLAFECITGFRPFLPN 226 >4OW8-A nrPDB Length = 283 Score = 181 bits (461), Expect = 2e-46, Method: Composition-based stats. Identities = 62/280 (22%), Positives = 100/280 (35%), Gaps = 37/280 (13%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLD-DDDEGVPSSALREICLLKELKHK 61 +Y I G G V++A + VA+K ++ + D E L H Sbjct: 12 RYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHP 71 Query: 62 NIVRLHDVLH-----SDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGF 116 I +HD + LV E + + G L L Q + L Sbjct: 72 GIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQI 131 Query: 117 CHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGI-PVRCYSAEVVTLWYRPPDVLFG 175 H+ ++HRD+KP N+LI G++K+ DFG+A+A PV + T Y P+ G Sbjct: 132 AHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQALG 191 Query: 176 AKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPD 235 S + D++S G + E + RP + +K I + P++ Sbjct: 192 HDA-SPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKEPPPPLPPDLPPNV----- 245 Query: 236 YKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRI 275 R+L++ L NP R Sbjct: 246 ------------------------RELIEITLVKNPAMRY 261 >6CTH-A nrPDB Length = 309 Score = 181 bits (461), Expect = 2e-46, Method: Composition-based stats. Identities = 58/212 (27%), Positives = 100/212 (47%), Gaps = 8/212 (3%) Query: 9 KIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHD 68 K+GEG +G+V++ R++ +A+K+V + E+ ++ L+HKN+V+L Sbjct: 22 KLGEGGFGSVYRGFLRDSDTYIAVKKVSR--ASKQGIKEYASEVKIISRLRHKNLVKLIG 79 Query: 69 VLHSDKKLTLVFEFC-DQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN---VLH 124 H +L LV+EF + L + L E+ + L L + H VLH Sbjct: 80 WCHERGELMLVYEFMANGSLDSHIFKGKSLLTWEVRYRIVKDLASALLYLHEEGDHCVLH 139 Query: 125 RDLKPQNLLINRNGELKLADFGLARAFGI-PVRCYSAEVVTLWYRPPDVLFGAKLYSTSI 183 RD+K N++++ + KL DFGLAR + T+ Y P+ L K S Sbjct: 140 RDIKTSNIMLDSSFNAKLGDFGLARLVDHAKGLKKTLLAGTVGYMAPECLSSGKA-SKES 198 Query: 184 DMWSAGCIFAELANAGRPLFPGNDVDDQLKRI 215 D++S G + E+A+ R + P + + L + Sbjct: 199 DVYSFGVVALEIASGRRSIEPKFEESEALLLV 230 >6B2Q-A nrPDB Length = 317 Score = 181 bits (461), Expect = 2e-46, Method: Composition-based stats. Identities = 62/280 (22%), Positives = 100/280 (35%), Gaps = 37/280 (13%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLD-DDDEGVPSSALREICLLKELKHK 61 +Y I G G V++A + VA+K ++ + D E L H Sbjct: 33 RYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHP 92 Query: 62 NIVRLHDVLH-----SDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGF 116 I +HD + LV E + + G L L Q + L Sbjct: 93 GIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQI 152 Query: 117 CHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGI-PVRCYSAEVVTLWYRPPDVLFG 175 H+ ++HRD+KP N+LI G++K+ DFG+A+A PV + T Y P+ G Sbjct: 153 AHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQALG 212 Query: 176 AKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPD 235 S + D++S G + E + RP + +K I + P++ Sbjct: 213 HDA-SPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKEPPPPLPPDLPPNV----- 266 Query: 236 YKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRI 275 R+L++ L NP R Sbjct: 267 ------------------------RELIEITLVKNPAMRY 282 >4X3F-A nrPDB Length = 337 Score = 181 bits (461), Expect = 2e-46, Method: Composition-based stats. Identities = 62/280 (22%), Positives = 100/280 (35%), Gaps = 37/280 (13%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLD-DDDEGVPSSALREICLLKELKHK 61 +Y I G G V++A + VA+K ++ + D E L H Sbjct: 13 RYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHP 72 Query: 62 NIVRLHDVLH-----SDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGF 116 I +HD + LV E + + G L L Q + L Sbjct: 73 GIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQI 132 Query: 117 CHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGI-PVRCYSAEVVTLWYRPPDVLFG 175 H+ ++HRD+KP N+LI G++K+ DFG+A+A PV + T Y P+ G Sbjct: 133 AHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQALG 192 Query: 176 AKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPD 235 S + D++S G + E + RP + +K I + P++ Sbjct: 193 HDA-SPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKEPPPPLPPDLPPNV----- 246 Query: 236 YKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRI 275 R+L++ L NP R Sbjct: 247 ------------------------RELIEITLVKNPAMRY 262 >3G0E-A nrPDB Length = 336 Score = 181 bits (460), Expect = 3e-46, Method: Composition-based stats. Identities = 67/290 (23%), Positives = 118/290 (40%), Gaps = 39/290 (13%) Query: 2 QKYEKLEKIGEGTYGTVFKAK-----NRETHEIVALKRVRLDDDDEGVPSSALREICLLK 56 + + +G G +G V +A + VA+K ++ + + E+ +L Sbjct: 46 NRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLK-PSAHLTEREALMSELKVLS 104 Query: 57 EL-KHKNIVRLHDVLHSDKKLTLVFEFC-DQDLKKYFDSCNGDL-----DPEIVK----- 104 L H NIV L ++ E+C DL + P I++ Sbjct: 105 YLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKTSPAIMEDDELA 164 Query: 105 -------SFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRC 157 SF +Q+ KG+ F S+N +HRDL +N+L+ K+ DFGLAR Sbjct: 165 LDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNY 224 Query: 158 Y---SAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKR 214 +A + W P+ +F +Y+ D+WS G EL + G +PG VD + + Sbjct: 225 VVKGNARLPVKW-MAPESIFNC-VYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYK 282 Query: 215 IFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQ 264 + + E + ++ P++ P MY + + P T + ++Q Sbjct: 283 MIK-------EGFRMLS--PEHAPAEMYDIMKTCWDADPLKRPTFKQIVQ 323 >2A1A-B nrPDB Length = 284 Score = 180 bits (458), Expect = 4e-46, Method: Composition-based stats. Identities = 71/298 (23%), Positives = 125/298 (41%), Gaps = 60/298 (20%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62 ++++E IG G +G VFKAK+R + +KRV+ +++ A RE+ L +L H N Sbjct: 12 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEK------AEREVKALAKLDHVN 65 Query: 63 IVRLHDVL----------------HSDKKLTLVFEFCD-QDLKKYFDSCNGD-LDPEIVK 104 IV + K L + EFCD L+++ + G+ LD + Sbjct: 66 IVHYNGCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLAL 125 Query: 105 SFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVT 164 Q+ KG+ + HS+ +++RDLKP N+ + ++K+ DFGL + + ++ T Sbjct: 126 ELFEQITKGVDYIHSKKLINRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSK-GT 184 Query: 165 LWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTE 224 L Y P+ + ++ Y +D+++ G I AEL + F + L+ Sbjct: 185 LRYMSPEQI-SSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGI-------- 235 Query: 225 EQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQ 282 + + + LLQ LL P R + E L+ Sbjct: 236 --------------------------ISDIFDKKEKTLLQKLLSKKPEDRPNTSEILR 267 >5UIU-A nrPDB Length = 323 Score = 180 bits (458), Expect = 5e-46, Method: Composition-based stats. Identities = 67/281 (23%), Positives = 113/281 (40%), Gaps = 26/281 (9%) Query: 9 KIGEGTYGTVFKAKNRETHEIVALKRV--RLDDDDEGVPSSALREICLLKELKHKNIVRL 66 K+GEG +G V+K T VA+K++ +D E + +EI ++ + +H+N+V L Sbjct: 54 KMGEGGFGVVYKGYVNNT--TVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVEL 111 Query: 67 HDVLHSDKKLTLVFEFC-DQDLKKYFDSCNG--DLDPEIVKSFLFQLLKGLGFCHSRNVL 123 L LV+ + + L +G L + G+ F H + + Sbjct: 112 LGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHI 171 Query: 124 HRDLKPQNLLINRNGELKLADFGLARAFGI--PVRCYSAEVVTLWYRPPDVLFGAKLYST 181 HRD+K N+L++ K++DFGLARA S V T Y P+ L G + Sbjct: 172 HRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGE--ITP 229 Query: 182 SIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPM 241 D++S G + E+ VD+ + +LL EE + DY M Sbjct: 230 KSDIYSFGVVLLEIITGLP------AVDEHRE--PQLLLDIKEEIEDEEKTIEDYIDKKM 281 Query: 242 YPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQ 282 A ++ V + + L +R ++ Q Sbjct: 282 NDADSTSVEAMYSVA-------SQCLHEKKNKRPDIKKVQQ 315 >5HVK-A nrPDB Length = 315 Score = 180 bits (458), Expect = 6e-46, Method: Composition-based stats. Identities = 63/296 (21%), Positives = 118/296 (39%), Gaps = 47/296 (15%) Query: 7 LEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRL 66 E +G+G +G K +RET E++ +K + DE + L+E+ +++ L+H N+++ Sbjct: 19 GEVLGKGCFGQAIKVTHRETGEVMVMKEL--IRFDEETQRTFLKEVKVMRCLEHPNVLKF 76 Query: 67 HDVLHSDKKLTLVFEFCDQD-LKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHR 125 VL+ DK+L + E+ L+ S + SF + G+ + HS N++HR Sbjct: 77 IGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHR 136 Query: 126 DLKPQNLLINRNGELKLADFGLARAF--------------GIPVRCYSAEVVTLWYRPPD 171 +L N L+ N + +ADFGLAR + V ++ P+ Sbjct: 137 NLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPE 196 Query: 172 VLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMT 231 ++ G + Y +D++S G + E+ I R+ P Sbjct: 197 MING-RSYDEKVDVFSFGIVLCEI-------------------IGRVNADPD-------- 228 Query: 232 KLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFS 287 LP + + P + + +P +R S + L+H + Sbjct: 229 YLPRTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCCDLDPEKRPSFVK-LEH-WLE 282 >5TQX-A nrPDB Length = 655 Score = 180 bits (457), Expect = 6e-46, Method: Composition-based stats. Identities = 74/282 (26%), Positives = 123/282 (43%), Gaps = 20/282 (7%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 +E E++G G +G V ++RE +A+K RL+ + EI ++K+L H N+ Sbjct: 10 WEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKN-RERWCHEIQIMKKLNHANV 68 Query: 64 VRLHDVLHSDKKLT-----LVFEFC-DQDLKKYFDSCNG--DLDPEIVKSFLFQLLKGLG 115 V+ DV L L E+C DL+K + L + S L + G+ Sbjct: 69 VKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSGIR 128 Query: 116 FCHSRNVLHRDLKPQNLLI-NRNGEL--KLADFGLARAFGIPVRCYSAEVVTLWYRPPDV 172 + H ++HRDLKP+N+++ + G++ K+ D G A+ C + V TL Y P+ Sbjct: 129 YLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGELC-TEFVGTLQYLAPE- 186 Query: 173 LFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTK 232 LF K Y+ ++D WS G + E RP ++I + M+ Sbjct: 187 LFENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKK-DPKCIFACEEMSG 245 Query: 233 LPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQR 274 + + P + + V P N LQ +L +P QR Sbjct: 246 EVRFSSHLPQPNSLCSLIVEPMENW-----LQLMLNWDPQQR 282 >6FER-A nrPDB Length = 309 Score = 180 bits (457), Expect = 7e-46, Method: Composition-based stats. Identities = 64/288 (22%), Positives = 112/288 (38%), Gaps = 32/288 (11%) Query: 8 EKIGEGTYGTVFKA--------KNRE--------THEIVALKRVRLDDDDEGVPSSALRE 51 EK+GEG +G V K+++ +VA+K +R D ++ + L+E Sbjct: 15 EKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRAD-ANKNARNDFLKE 73 Query: 52 ICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCD-QDLKKYFDSCNGD---------LDPE 101 I ++ LK NI+ L V +D L ++ E+ + DL ++ + Sbjct: 74 IKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPNSSSSDVRTVSYT 133 Query: 102 IVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAF--GIPVRCYS 159 +K Q+ G+ + S N +HRDL +N L+ +N +K+ADFG++R G R Sbjct: 134 NLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYYRIQG 193 Query: 160 AEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAG--RPLFPGNDVDDQLKRIFR 217 V+ + + + + K ++T+ D+W+ G E +P +D Sbjct: 194 RAVLPIRWMSWESILLGK-FTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIENTGEF 252 Query: 218 LLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQN 265 + P PD M P LLQ Sbjct: 253 FRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIHLLLLQQ 300 >5GRN-A nrPDB Length = 356 Score = 180 bits (457), Expect = 7e-46, Method: Composition-based stats. Identities = 65/299 (21%), Positives = 113/299 (37%), Gaps = 48/299 (16%) Query: 6 KLEKIGEGTYGTVFKAKNRETHE-----IVALKRVRLDDDDEGVPSSALREICLLKELK- 59 +G G +G V + VA+K ++ + + E+ ++ L Sbjct: 50 LGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLK-PTARSSEKQALMSELKIMTHLGP 108 Query: 60 HKNIVRLHDVLHSDKKLTLVFEFC-DQDLKKYFDSCNGD--------------------- 97 H NIV L + ++ E+C DL Y Sbjct: 109 HLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHKKKSMLDSEVKNLLSDD 168 Query: 98 ----LDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGI 153 L + SF +Q+ +G+ F S+N +HRDL +N+L+ + +K+ DFGLAR Sbjct: 169 NSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMH 228 Query: 154 PVRCYS--AEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQ 211 S + + + + P+ +F LY+T D+WS G + E+ + G +PG VD Sbjct: 229 DSNYVSKGSTFLPVKWMAPESIFDN-LYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDST 287 Query: 212 LKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDL---LQNLL 267 + + PD+ +Y N P+ + L ++NLL Sbjct: 288 FY---------NKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLL 337 >4TPT-A nrPDB Length = 303 Score = 178 bits (453), Expect = 2e-45, Method: Composition-based stats. Identities = 59/276 (21%), Positives = 108/276 (39%), Gaps = 32/276 (11%) Query: 7 LEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRL 66 E +G+G +G K ++ T +++ +K + DE + L E+ +++ L H N+++ Sbjct: 5 GEVLGKGFFGQAIKVTHKATGKVMVMKEL--IRCDEETQKTFLTEVKVMRSLDHPNVLKF 62 Query: 67 HDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRD 126 VL+ DKKL L+ E+ + K F + F + G+ + HS ++HRD Sbjct: 63 IGVLYKDKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMAYLHSMCIIHRD 122 Query: 127 LKPQNLLINRNGELKLADFGLARAF--------------------GIPVRCYSAEVVTLW 166 L N LI + + +ADFGL+R + V + Sbjct: 123 LNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGNPY 182 Query: 167 YRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQ 226 + P++L G K Y ++D++S G + E+ V + R L + Sbjct: 183 WMAPEMLNG-KSYDETVDIFSFGIVLCEII---------GQVYADPDCLPRTLDFGLNVK 232 Query: 227 WPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDL 262 +P P +P + P+ L Sbjct: 233 LFWEKFVPTDCPPAFFPLAAICCRLEPESRPAFSKL 268 >4C59-A nrPDB Length = 340 Score = 178 bits (452), Expect = 2e-45, Method: Composition-based stats. Identities = 67/305 (21%), Positives = 116/305 (38%), Gaps = 61/305 (20%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELK-HK 61 + + EG + V++A++ + ALKR+ ++E + ++E+C +K+L H Sbjct: 28 RLRVRRVLAEGGFAFVYEAQDVGSGREYALKRLL--SNEEEKNRAIIQEVCFMKKLSGHP 85 Query: 62 NIVRL-----HDVLHSDK---KLTLVFEFCDQDLKKYFDS--CNGDLDPEIVKSFLFQLL 111 NIV+ SD + L+ E C L ++ G L + V +Q Sbjct: 86 NIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGPLSCDTVLKIFYQTC 145 Query: 112 KGLGFCHSRN--VLHRDLKPQNLLINRNGELKLADFGLARAF-GIPVRCYSAEV------ 162 + + H + ++HRDLK +NLL++ G +KL DFG A P +SA+ Sbjct: 146 RAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEE 205 Query: 163 -----VTLWYRPPDVLFGAKLY--STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRI 215 T YR P+++ + D+W+ GCI L P G + RI Sbjct: 206 EITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDGAKL-----RI 260 Query: 216 FRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRI 275 + L++ +L+ NP +R+ Sbjct: 261 VNGKYSIPPHDTQYTV---------------------------FHSLIRAMLQVNPEERL 293 Query: 276 SAEEA 280 S E Sbjct: 294 SIAEV 298 >4X7Q-B nrPDB Length = 312 Score = 178 bits (452), Expect = 3e-45, Method: Composition-based stats. Identities = 66/296 (22%), Positives = 112/296 (37%), Gaps = 50/296 (16%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVP----SSALREICLLKEL 58 +Y +G+G +GTVF VA+K + + P + E+ LL ++ Sbjct: 32 EYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKV 91 Query: 59 K----HKNIVRLHDVLHSDKKLTLVFE--FCDQDLKKYFDSCNGDLDPEIVKSFLFQLLK 112 H ++RL D + + LV E QDL Y + G L + F Q++ Sbjct: 92 GAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYI-TEKGPLGEGPSRCFFGQVVA 150 Query: 113 GLGFCHSRNVLHRDLKPQNLLIN-RNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPD 171 + CHSR V+HRD+K +N+LI+ R G KL DFG Y+ T Y PP+ Sbjct: 151 AIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLH--DEPYTDFDGTRVYSPPE 208 Query: 172 VLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMT 231 + + ++ +WS G + ++ P ++ + Sbjct: 209 WISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEILE--------------------- 247 Query: 232 KLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFS 287 + ++ ++ L++ L P R S EE L P+ Sbjct: 248 ---------------AELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQ 288 >3PLS-A nrPDB Length = 298 Score = 178 bits (451), Expect = 3e-45, Method: Composition-based stats. Identities = 60/265 (22%), Positives = 117/265 (44%), Gaps = 21/265 (7%) Query: 8 EKIGEGTYGTVFKAKNRETHE---IVALKRVRLDDDDEGVPSSALREICLLKELKHKNIV 64 IG+G +G V+ + + + A+K + + + V + LRE L++ L H N++ Sbjct: 27 RVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQV-EAFLREGLLMRGLNHPNVL 85 Query: 65 RLHDVLHSDKKL-TLVFEF-CDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNV 122 L ++ + L ++ + C DL ++ S + + + SF Q+ +G+ + + Sbjct: 86 ALIGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLAEQKF 145 Query: 123 LHRDLKPQNLLINRNGELKLADFGLARAF----GIPVRCYSAEVVTLWYRPPDVLFGAKL 178 +HRDL +N +++ + +K+ADFGLAR V+ + + + + + L + Sbjct: 146 VHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWTALESLQTYR- 204 Query: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKP 238 ++T D+WS G + EL G P + D D + + P P+Y P Sbjct: 205 FTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQ----------PEYCP 254 Query: 239 YPMYPATTSLVNVVPKLNATGRDLL 263 +Y P + T R L+ Sbjct: 255 DSLYQVMQQCWEADPAVRPTFRVLV 279 >5U6B-A nrPDB Length = 307 Score = 178 bits (451), Expect = 4e-45, Method: Composition-based stats. Identities = 56/293 (19%), Positives = 109/293 (37%), Gaps = 45/293 (15%) Query: 6 KLEKIGEGTYGTVFKAKNRETHEI--VALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 + +GEG +G V + + + I VA+K +++ L E +KE H N+ Sbjct: 27 LGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNV 86 Query: 64 VRLHDVLHSDKKL------TLVFEFCD-QDLKKYFDSCN-----GDLDPEIVKSFLFQLL 111 +RL V + ++ F DL + L +++ F+ + Sbjct: 87 MRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIA 146 Query: 112 KGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVV--TLWYRP 169 G+ + ++ +HRDL +N ++N N + +ADFGL++ + + + Sbjct: 147 SGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIA 206 Query: 170 PDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPS 229 + L ++Y++ D+WS G E+A G+ +PG + + Sbjct: 207 IESL-ADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEI------------------ 247 Query: 230 MTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQ 282 Y + + L A L+ + NP R S E + Sbjct: 248 ------YDYLRQGNRLKQPADCLDGLYA----LMSRCWELNPQDRPSFTELRE 290 >3UIU-A nrPDB Length = 306 Score = 176 bits (446), Expect = 1e-44, Method: Composition-based stats. Identities = 71/311 (22%), Positives = 125/311 (40%), Gaps = 73/311 (23%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62 ++++E IG G +G VFKAK+R + ++RV+ +++ A RE+ L +L H N Sbjct: 13 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIRRVKYNNEK------AEREVKALAKLDHVN 66 Query: 63 IVRLHDVL-----------------------------HSDKKLTLVFEFCD-QDLKKYFD 92 IV + K L + EFCD L+++ + Sbjct: 67 IVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIE 126 Query: 93 SCNGD-LDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAF 151 G+ LD + Q+ KG+ + HS+ ++HRDLKP N+ + ++K+ DFGL + Sbjct: 127 KRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSL 186 Query: 152 GIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQ 211 + ++ TL Y P+ + ++ Y +D+++ G I AEL + F + Sbjct: 187 KNDGKRTRSK-GTLRYMSPEQI-SSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTD 244 Query: 212 LKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNP 271 L+ + + + LLQ LL P Sbjct: 245 LRDGI----------------------------------ISDIFDKKEKTLLQKLLSKKP 270 Query: 272 VQRISAEEALQ 282 R + E L+ Sbjct: 271 EDRPNTSEILR 281 >5TOS-A nrPDB Length = 395 Score = 176 bits (446), Expect = 1e-44, Method: Composition-based stats. Identities = 68/299 (22%), Positives = 115/299 (38%), Gaps = 34/299 (11%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRE---------THEIVALKRVRLDDDDEGVPSSALREI 52 + + IGEG +G VFK E T ++A+K++ + L EI Sbjct: 65 RNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQ--GHREWLTEI 122 Query: 53 CLLKELKHKNIVRLHDVLHSDKKLTLVFEFC-DQDLKKYFDSCN---GDLDPEIVKSFLF 108 L +L H N+V+L D+ LV+EF L+ + L + + Sbjct: 123 NYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVAL 182 Query: 109 QLLKGLGFCHSR--NVLHRDLKPQNLLINRNGELKLADFGLARA--FGIPVRCYSAEVVT 164 KGL F HS V++RD+K N+L++ + KL+DFGLAR G + + T Sbjct: 183 DAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGT 242 Query: 165 LWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDV-DDQLKRIFRLLGTPT 223 Y P+ + + D++S G + E+ + R L ++ L R T Sbjct: 243 YGYAAPE-YMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSK 301 Query: 224 EEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQ 282 + + D + P + V V L P R + ++ ++ Sbjct: 302 RKVLLIVDNRLDTQYLPEEAVRMASVAV-------------QCLSFEPKSRPTMDQVVR 347 >3ZZW-A nrPDB Length = 289 Score = 176 bits (446), Expect = 1e-44, Method: Composition-based stats. Identities = 62/283 (21%), Positives = 116/283 (40%), Gaps = 35/283 (12%) Query: 7 LEKIGEGTYGTVFKAKNR-----ETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 +E++GE +G V+K E + VA+K ++ D + + E L L+H Sbjct: 14 MEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLK-DKAEGPLREEFRHEAMLRARLQHP 72 Query: 62 NIVRLHDVLHSDKKLTLVFEFCD-QDLKKYF---------------DSCNGDLDPEIVKS 105 N+V L V+ D+ L+++F +C DL ++ + L+P Sbjct: 73 NVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVH 132 Query: 106 FLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAF--GIPVRCYSAEVV 163 + Q+ G+ + S +V+H+DL +N+L+ +K++D GL R + ++ Sbjct: 133 LVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSLL 192 Query: 164 TLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPT 223 + + P+ + K +S D+WS G + E+ + G + G D ++ I P Sbjct: 193 PIRWMAPEAIMYGK-FSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLP- 250 Query: 224 EEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNL 266 PD P +Y N P +D+ L Sbjct: 251 ---------CPDDCPAWVYALMIECWNEFPSRRPRFKDIHSRL 284 >2PMN-X nrPDB Length = 348 Score = 176 bits (446), Expect = 1e-44, Method: Composition-based stats. Identities = 61/314 (19%), Positives = 130/314 (41%), Gaps = 41/314 (13%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVP--------------- 45 + Y + + +G + + + + ++ ALK+ ++ Sbjct: 30 INDYRIIRTLNQGKFNKIILCE--KDNKFYALKKYEKSLLEKKRDFTKSNNDKISIKSKY 87 Query: 46 SSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDP----- 100 E+ ++ ++K++ + ++ + ++ +++E+ + D FD LD Sbjct: 88 DDFKNELQIITDIKNEYCLTCEGIITNYDEVYIIYEYMENDSILKFDEYFFVLDKNYTCF 147 Query: 101 ---EIVKSFLFQLLKGLGFCH-SRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVR 156 +++K + +L + H +N+ HRD+KP N+L+++NG +KL+DFG + + Sbjct: 148 IPIQVIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMDKNGRVKLSDFGESEYMV--DK 205 Query: 157 CYSAEVVTLWYRPPDVLFGAKLY-STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRI 215 T + PP+ Y +D+WS G + P + L + Sbjct: 206 KIKGSRGTYEFMPPEFFSNESSYNGAKVDIWSLGICLYVMFYNVVPF----SLKISLVEL 261 Query: 216 FRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPK-LNATGRDLLQNLLKCNPVQR 274 F + T E P + + +YP T L+ D L+ L+ NP +R Sbjct: 262 FNNIRTKNIE-------YPLDRNHFLYPLTNKKSTCSNNFLSNEDIDFLKLFLRKNPAER 314 Query: 275 ISAEEALQHPYFSD 288 I++E+AL+H + +D Sbjct: 315 ITSEDALKHEWLAD 328 >6J5U-C nrPDB Length = 426 Score = 175 bits (445), Expect = 2e-44, Method: Composition-based stats. Identities = 70/289 (24%), Positives = 115/289 (39%), Gaps = 34/289 (11%) Query: 10 IGEGTYGTVFKAKNRET---------HEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 +GEG +G VFK +T +VA+K+++ + L E+ L +L H Sbjct: 92 LGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQLKPEGFQ--GHKEWLTEVNYLGQLSH 149 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCDQDLKK--YFDSCNGDLDPEIVKSFLFQLLKGLGFCH 118 N+V L + LV+EF + + F L I KGL F H Sbjct: 150 PNLVLLVGYCAEGENRLLVYEFMPKGSLENHLFRRGAQPLTWAIRMKVAVGAAKGLTFLH 209 Query: 119 SRN--VLHRDLKPQNLLINRNGELKLADFGLARA--FGIPVRCYSAEVVTLWYRPPDVLF 174 V++RD K N+L++ + KL+DFGLA+A G + + T Y P+ + Sbjct: 210 EAKSQVIYRDFKAANILLDADFNAKLSDFGLAKAGPTGDNTHVSTKVIGTHGYAAPEYVA 269 Query: 175 GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLG--TPTEEQWPSMTK 232 +L + D++S G + EL + R + N ++ + L+ TP + + Sbjct: 270 TGRL-TAKSDVYSFGVVLLELISGRRAMDNSNGGNE-----YSLVDWATPYLGDKRKLFR 323 Query: 233 LPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEAL 281 + D K YP + T +L L + R E L Sbjct: 324 IMDTKLGGQYPQKGAF---------TAANLALQCLNPDAKLRPKMSEVL 363 >2RIO-A nrPDB Length = 434 Score = 173 bits (440), Expect = 6e-44, Method: Composition-based stats. Identities = 77/309 (24%), Positives = 135/309 (43%), Gaps = 60/309 (19%) Query: 8 EKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELK-HKNIVRL 66 + +G G+ GTV + VA+KR+ +D D AL EI LL E H N++R Sbjct: 21 KILGYGSSGTVVF-QGSFQGRPVAVKRMLIDFCD-----IALMEIKLLTESDDHPNVIRY 74 Query: 67 HDVLHSDKKLTLVFEFCDQDLKKYFDSCN-GDLDPEIVKSF-----LFQLLKGLGFCHSR 120 + +D+ L + E C+ +L+ +S N D + ++ K + L Q+ G+ HS Sbjct: 75 YCSETTDRFLYIALELCNLNLQDLVESKNVSDENLKLQKEYNPISLLRQIASGVAHLHSL 134 Query: 121 NVLHRDLKPQNLLIN-------------RNGELKLADFGLARAFGIPVRCYSAEV----V 163 ++HRDLKPQN+L++ N + ++DFGL + + + Sbjct: 135 KIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFRTNLNNPSG 194 Query: 164 TLWYRPPDVLFG------AKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFR 217 T +R P++L + + SID++S GC+F + + G+ F D + I R Sbjct: 195 TSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPF--GDKYSRESNIIR 252 Query: 218 LLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISA 277 + + E + L A DL+ ++ +P++R +A Sbjct: 253 GIFSLDEMKCLHDRSLI----------------------AEATDLISQMIDHDPLKRPTA 290 Query: 278 EEALQHPYF 286 + L+HP F Sbjct: 291 MKVLRHPLF 299 >5WNL-A nrPDB Length = 342 Score = 173 bits (439), Expect = 8e-44, Method: Composition-based stats. Identities = 53/284 (18%), Positives = 116/284 (40%), Gaps = 31/284 (10%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62 ++ EK+G G +G V+K ++ +A+K D+ L E ++ K + Sbjct: 21 EFAGWEKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRERMELLEEAKKMEMAKFRY 80 Query: 63 IVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCH--SR 120 I+ ++ + + + LV E+ + + + L ++ + + G+ F H S Sbjct: 81 ILPVYGICQ--EPVGLVMEYMETGSLEKLLASE-PLPWDLRFRIVHETAVGMNFLHCMSP 137 Query: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVR---CYSAEVVTLWYRPPDVL-FGA 176 +LH +LKP N+L++ + +K++DFGLA+ G+ T+ Y PP+ + + Sbjct: 138 PLLHLNLKPANILLDAHYHVKISDFGLAKCNGMSHSHDLSMDGLFGTIAYLPPERIREKS 197 Query: 177 KLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDY 236 +L+ T D++S + + +P ++ + ++ + Sbjct: 198 RLFDTKHDVYSFAIVIWGVLTQKKPFADEKNILHIMMKVVK------------------- 238 Query: 237 KPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEA 280 P + P+ A+ L+Q +P R + +E Sbjct: 239 ---GHRPELPPICRPRPRACASLIGLMQRCWHADPQVRPTFQEI 279 >5U6C-A nrPDB Length = 315 Score = 173 bits (438), Expect = 9e-44, Method: Composition-based stats. Identities = 58/283 (20%), Positives = 111/283 (39%), Gaps = 24/283 (8%) Query: 6 KLEKIGEGTYGTVFKAKNRE---THEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62 + +GEG +G+V + ++ T VA+K ++LD+ + L E +K+ H N Sbjct: 40 LGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPN 99 Query: 63 IVRLHDVLHSD-----KKLTLVFEFCD-QDLKKYFDSCNGDLDPEIV-----KSFLFQLL 111 ++RL V K ++ F DL Y + P+ + F+ + Sbjct: 100 VMRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIA 159 Query: 112 KGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVV--TLWYRP 169 G+ + +RN LHRDL +N ++ + + +ADFGL++ + + + Sbjct: 160 LGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIA 219 Query: 170 PDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPS 229 + L ++Y++ D+W+ G E+A G +PG + + E Sbjct: 220 IESL-ADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLD 278 Query: 230 MTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPV 272 Y + P +V+ L+ LL+ P Sbjct: 279 ELYEIMYSCWRTDPLDRPTFSVLRLQ-------LEKLLESLPD 314 >3M42-A nrPDB Length = 299 Score = 173 bits (438), Expect = 1e-43, Method: Composition-based stats. Identities = 68/297 (22%), Positives = 111/297 (37%), Gaps = 63/297 (21%) Query: 1 MQKYEKL-EKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLL-KEL 58 + Y+ + +G G G V + N+ T E ALK ++ A RE+ L + Sbjct: 16 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ-------DCPKARREVELHWRAS 68 Query: 59 KHKNIVRLHDVLHS----DKKLTLVFEFCDQDLK--KYFDSCNGDLDPEIVKSFLFQLLK 112 + +IVR+ DV + K L +V E D + D + + + + Sbjct: 69 QCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGE 128 Query: 113 GLGFCHSRNVLHRDLKPQNLLINR---NGELKLADFGLARAFGIPVRCYSAEVVTLWYRP 169 + + HS N+ HRD+KP+NLL N LKL DFG A+ Sbjct: 129 AIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT----------------- 171 Query: 170 PDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPS 229 + Y S DMWS G I L P + + G + Sbjct: 172 ------GEKYDKSCDMWSLGVIMYILLCGYPPFYSNH-------------GLAISPGMKT 212 Query: 230 MTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286 ++ Y+ +++ + L++NLLK P QR++ E + HP+ Sbjct: 213 RIRMGQYEFPNP---------EWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 260 >4PL5-B nrPDB Length = 435 Score = 172 bits (437), Expect = 1e-43, Method: Composition-based stats. Identities = 71/291 (24%), Positives = 124/291 (42%), Gaps = 45/291 (15%) Query: 8 EKIGEGTYGT-VFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELK-HKNIVR 65 + +G G GT V+K + VA+KR+ + S A RE+ LL+E H N++R Sbjct: 33 DVLGHGAEGTIVYKG--MFDNRDVAVKRILPE-----CFSFADREVQLLRESDEHPNVIR 85 Query: 66 LHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHR 125 + + E C L++Y + + + L Q GL HS N++HR Sbjct: 86 YFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITLLHQTTSGLAHLHSLNIVHR 145 Query: 126 DLKPQNLLI---NRNGELK--LADFGLARAFGIPVRCYSAEV---VTLWYRPPDVLFGAK 177 DLKP N+L+ N +G +K ++DFGL + + +S T + P++L Sbjct: 146 DLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDC 205 Query: 178 LY--STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPD 235 + ++D++SAGC+F + + G F G + Q + Sbjct: 206 KDNPTYTVDIFSAGCVFYYVISEGYHPF-GKSLQRQANILLGAC---------------- 248 Query: 236 YKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286 + + R+L++ ++ +P QR SA+ L+HP+F Sbjct: 249 ---------NLDCFHSDKHEDVIARELIEKMIAMDPQQRPSAKHVLKHPFF 290 >5WNO-A nrPDB Length = 330 Score = 172 bits (436), Expect = 2e-43, Method: Composition-based stats. Identities = 48/268 (17%), Positives = 105/268 (39%), Gaps = 15/268 (5%) Query: 5 EKLEKIGEGTYGTVFKA-----KNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELK 59 + +K+G G +GTVF + + VA+K D+ L E + L+ Sbjct: 25 KLDKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVF---QTDQSQTDEMLEEATNMFRLR 81 Query: 60 HKNIVRLHDVLHSDKKLTLVFEFCD-QDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCH 118 H N++++ D L +V + +L+ + +L + +Q+ G+ + Sbjct: 82 HDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKENLGAREQVLYCYQIASGMQYLE 141 Query: 119 SRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVV--TLWYRPPDVLFGA 176 + V+HRDL +N+L+ + +++ DFGL++ + + + + + +F Sbjct: 142 KQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIE-IFSK 200 Query: 177 KLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDY 236 Y+ + D+W+ G E+ G+ + G D L Q P+ ++ Sbjct: 201 HCYTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNF---LKDGNRLSQPPNCSQDLYQ 257 Query: 237 KPYPMYPATTSLVNVVPKLNATGRDLLQ 264 + + A L ++ + Sbjct: 258 ELLRCWMADPKSRPGFEILYERFKEFCK 285 >3QUP-A nrPDB Length = 323 Score = 172 bits (436), Expect = 2e-43, Method: Composition-based stats. Identities = 59/292 (20%), Positives = 114/292 (39%), Gaps = 46/292 (15%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETH---EIVALKRVRLDDDDEGVPSSALREICLLKEL 58 Q++ +G+G +G+V +A+ ++ VA+K ++ D LRE +KE Sbjct: 23 QQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEF 82 Query: 59 KHKNIVRLHDVL---HSDKKL---TLVFEFCD-QDLKKYFDSCN-----GDLDPEIVKSF 106 H ++ +L V + +L ++ F DL + + +L + + F Sbjct: 83 DHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLVRF 142 Query: 107 LFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAF--GIPVRCYSAEVVT 164 + + G+ + SRN +HRDL +N ++ + + +ADFGL+R G R A + Sbjct: 143 MVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLP 202 Query: 165 LWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTE 224 + + + L LY+ D+W+ G E+ G+ + G + + Sbjct: 203 VKWLALESL-ADNLYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYN----------- 250 Query: 225 EQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRIS 276 Y + + P+ DL+ +P QR S Sbjct: 251 -----------------YLIGGNRLKQPPECMEEVYDLMYQCWSADPKQRPS 285 >4FL3-A nrPDB Length = 635 Score = 171 bits (434), Expect = 3e-43, Method: Composition-based stats. Identities = 49/227 (21%), Positives = 103/227 (45%), Gaps = 7/227 (3%) Query: 8 EKIGEGTYGTVFKAKNR--ETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVR 65 +++G G +GTV K + + + VA+K ++ + +D + L E ++++L + IVR Sbjct: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 Query: 66 LHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHR 125 + + ++ + LV E + + N + + + + Q+ G+ + N +HR Sbjct: 435 MIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHR 493 Query: 126 DLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLW---YRPPDVLFGAKLYSTS 182 DL +N+L+ K++DFGL++A Y A+ W + P+ + K +S+ Sbjct: 494 DLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYK-FSSK 552 Query: 183 IDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPS 229 D+WS G + E + G+ + G + + + P Sbjct: 553 SDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPR 599 >4NEU-A nrPDB Length = 333 Score = 171 bits (433), Expect = 4e-43, Method: Composition-based stats. Identities = 47/262 (17%), Positives = 97/262 (37%), Gaps = 22/262 (8%) Query: 12 EGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLH 71 G +G V +R ++ +K V + + L E ++ L+H +V+L V+ Sbjct: 34 SGGFGKVSLCFHRTQGLMI-MKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVII 92 Query: 72 SDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQN 131 + K +LV E+ ++ + + + ++++G+ + H + V+H+DLKP+N Sbjct: 93 EEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCYLHGKGVIHKDLKPEN 152 Query: 132 LLINRNGELKLADFGLAR-------------AFGIPVRCYSAEVVTLWYRPPDVLFGAK- 177 +L++ + +K+AD GLA TL+Y P+ L Sbjct: 153 ILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHLNDVNA 212 Query: 178 LYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYK 237 + D++S + + P + I P + + +Y Sbjct: 213 KPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCI-------KSGNRPDVDDITEYC 265 Query: 238 PYPMYPATTSLVNVVPKLNATG 259 P + P+ T Sbjct: 266 PREIISLMKLCWEANPEARPTF 287 >3ZBF-A nrPDB Length = 322 Score = 171 bits (433), Expect = 5e-43, Method: Composition-based stats. Identities = 54/281 (19%), Positives = 103/281 (36%), Gaps = 22/281 (7%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRE-----THEI-VALKRVRLDDDDEGVPSSALREICLL 55 +K +G G +G V++ + + EI VA+K ++ D+ L+E L+ Sbjct: 33 EKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIE-FLKEAHLM 91 Query: 56 KELKHKNIVRLHDVLHSDKKLTLVFEFCDQ-DLKKYFDSCN------GDLDPEIVKSFLF 108 + H NI++ V ++ ++ E + DL Y L + Sbjct: 92 SKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCV 151 Query: 109 QLLKGLGFCHSRNVLHRDLKPQNLLI-----NRNGELKLADFGLARAF--GIPVRCYSAE 161 + KG + + +HRDL +N L+ +K+ DFGLAR R Sbjct: 152 DISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEG 211 Query: 162 VVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGT 221 ++ + + P+ L +++T D+WS G + E+ G +P + D L + Sbjct: 212 LLPVRWMAPESLMDG-IFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRL 270 Query: 222 PTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDL 262 P + + P + + R+ Sbjct: 271 EPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNF 311 >4IDT-A nrPDB Length = 356 Score = 170 bits (431), Expect = 7e-43, Method: Composition-based stats. Identities = 62/303 (20%), Positives = 110/303 (36%), Gaps = 54/303 (17%) Query: 9 KIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHD 68 ++G G++G V + ++++T A+K+VRL+ E+ L IV L+ Sbjct: 81 RLGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFR-------AEELMACAGLTSPRIVPLYG 133 Query: 69 VLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLK 128 + + + E + G L + +L Q L+GL + HSR +LH D+K Sbjct: 134 AVREGPWVNIFMELLEGGSLGQLVKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVK 193 Query: 129 PQNLLINRNG-ELKLADFGLARAFGIPVRCYSAEV-----VTLWYRPPDVLFGAKLYSTS 182 N+L++ +G L DFG A T + P+V+ G + Sbjct: 194 ADNVLLSSDGSHAALCDFGHAVCLQPDGLGKDLLTGDYIPGTETHMAPEVVLG-RSCDAK 252 Query: 183 IDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMY 242 +D+WS+ C+ + N P W + P Sbjct: 253 VDVWSSCCMMLHMLNGCHP-------------------------WTQFFRGPLCLKIASE 287 Query: 243 PATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEA-------------LQHPYFSDF 289 P + + P +Q L+ P+ R+SA E L+ P+ ++ Sbjct: 288 P--PPVREIPPSCAPLTAQAIQEGLRKEPIHRVSAAELGGKVNRALQQVGGLKSPWRGEY 345 Query: 290 CPP 292 P Sbjct: 346 KEP 348 >4Y83-A nrPDB Length = 332 Score = 170 bits (431), Expect = 7e-43, Method: Composition-based stats. Identities = 62/283 (21%), Positives = 111/283 (39%), Gaps = 35/283 (12%) Query: 10 IGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDV 69 I G +G V+ A++ +T + +A K + +D + + +H+NI L+ Sbjct: 81 IPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSD-------VEIQACFRHENIAELYGA 133 Query: 70 LHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKP 129 + + + L E + G + + +LKGL F HS+ V+H D+KP Sbjct: 134 VLWGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHHDIKP 193 Query: 130 QNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAG 189 N++ + L DFGL+ V T Y P+V+ + +ST D++S G Sbjct: 194 SNIVFMSTKAV-LVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVIL-CRGHSTKADIYSLG 251 Query: 190 CIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLV 249 + GTP + + P Y Y ++ L Sbjct: 252 ATLIHMQT----------------------GTPPWVKRYPRSAYPSYL-YIIHKQAPPLE 288 Query: 250 NVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 292 ++ + R+L++ L+ NP R A + L+H + PP Sbjct: 289 DIADDCSPGMRELIEASLERNPNHRPRAADLLKHEALN---PP 328 >3LLT-A nrPDB Length = 360 Score = 170 bits (431), Expect = 7e-43, Method: Composition-based stats. Identities = 74/332 (22%), Positives = 136/332 (40%), Gaps = 56/332 (16%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 + + K+G+GT+G V ++ + + A+K VR + + SA E +LK++++ +I Sbjct: 37 FLVIRKMGDGTFGRVLLCQHIDNKKYYAVKVVR---NIKKYTRSAKIEADILKKIQNDDI 93 Query: 64 -----VRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGD-LDPEIVKSFLFQLLKGLGFC 117 V+ H + L+FE L + N + E +K + ++LK L + Sbjct: 94 NNNNIVKYHGKFMYYDHMCLIFEPLGPSLYEIITRNNYNGFHIEDIKLYCIEILKALNYL 153 Query: 118 HSRNVLHRDLKPQNLLIN-------------------------RNGELKLADFGLARAFG 152 ++ H DLKP+N+L++ ++ +KL DFG A Sbjct: 154 RKMSLTHTDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRTKSTGIKLIDFGCAT--- 210 Query: 153 IPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQL 212 + + + T YR P+V+ + S DMWS GC+ AEL LF ++ + L Sbjct: 211 FKSDYHGSIINTRQYRAPEVILNL-GWDVSSDMWSFGCVLAELYTGSL-LFRTHEHMEHL 268 Query: 213 KRIFRLLGTPTEEQWPSMTKLPDYKPYPM------YPATTSLVNVVPKL----------- 255 + ++ + TK K +P S +N + + Sbjct: 269 AMMESIIQPIPKNMLYEATKTNGSKYVNKDELKLAWPENASSINSIKHVKKCLPLYKIIK 328 Query: 256 NATGRDLLQNLLKCNPVQRISAEEALQHPYFS 287 + D L ++L+ +P R S E L+H + Sbjct: 329 HELFCDFLYSILQIDPTLRPSPAELLKHKFLE 360 >4F9B-A nrPDB Length = 361 Score = 170 bits (430), Expect = 9e-43, Method: Composition-based stats. Identities = 81/344 (23%), Positives = 132/344 (38%), Gaps = 65/344 (18%) Query: 4 YEKLEKIGEGTYGTVFKAKNRET---HEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 ++ +KIGEGT+ +V+ A + E +ALK + P E+ L Sbjct: 23 FKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHL----IPTSHPIRIAAELQCLTVAGG 78 Query: 61 K-NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 + N++ + + + + + + + + D N L + V+ ++ L K L H Sbjct: 79 QDNVMGVKYCFRKNDHVVIAMPYLEHE--SFLDILN-SLSFQEVREYMLNLFKALKRIHQ 135 Query: 120 RNVLHRDLKPQNLLINRN-GELKLADFGLARAFGIPV----------------------- 155 ++HRD+KP N L NR + L DFGLA+ Sbjct: 136 FGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNKCSI 195 Query: 156 -----RCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDD 210 + + T +R P+VL +T+IDMWSAG IF L + P + +D Sbjct: 196 CLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDDLT 255 Query: 211 QLKRIFRLLGTPTEEQWPSMT--------KLPDYKPYPMYPATTSLVNVVPKLNATGRDL 262 L +I + G+ Q ++P + + + PKL + + Sbjct: 256 ALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSSTPKLTSDIQGH 315 Query: 263 LQNL-----------------LKCNPVQRISAEEALQHPYFSDF 289 NL L NP RI+AEEAL HP+F D Sbjct: 316 ATNLEGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFFKDM 359 >6HV0-A nrPDB Length = 416 Score = 169 bits (429), Expect = 1e-42, Method: Composition-based stats. Identities = 70/291 (24%), Positives = 128/291 (43%), Gaps = 45/291 (15%) Query: 8 EKIGEGTYGT-VFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELK-HKNIVR 65 + +G G GT V++ + VA+KR+ + S A RE+ LL+E H N++R Sbjct: 14 DVLGHGAEGTIVYRG--MFDNRDVAVKRILPE-----CFSFADREVQLLRESDEHPNVIR 66 Query: 66 LHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHR 125 + + E C L++Y + + + L Q GL HS N++HR Sbjct: 67 YFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITLLQQTTSGLAHLHSLNIVHR 126 Query: 126 DLKPQNLLI---NRNGELK--LADFGLARAFGIPVRCYSAEVV---TLWYRPPDVLFG-- 175 DLKP N+LI N +G++K ++DFGL + + +S T + P++L Sbjct: 127 DLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDC 186 Query: 176 AKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPD 235 + + ++D++SAGC+F + + G F G + Q + Sbjct: 187 KENPTYTVDIFSAGCVFYYVISEGSHPF-GKSLQRQANILLGAC---------------- 229 Query: 236 YKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286 + ++ + R+L++ ++ +P +R SA+ L+HP+F Sbjct: 230 ---------SLDCLHPEKHEDVIARELIEKMIAMDPQKRPSAKHVLKHPFF 271 >5C26-A nrPDB Length = 299 Score = 167 bits (424), Expect = 4e-42, Method: Composition-based stats. Identities = 49/227 (21%), Positives = 103/227 (45%), Gaps = 7/227 (3%) Query: 8 EKIGEGTYGTVFKAKNR--ETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVR 65 +++G G +GTV K + + + VA+K ++ + +D + L E ++++L + IVR Sbjct: 33 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 92 Query: 66 LHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHR 125 + + ++ + LV E + + N + + + + Q+ G+ + N +HR Sbjct: 93 MIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHR 151 Query: 126 DLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLW---YRPPDVLFGAKLYSTS 182 DL +N+L+ K++DFGL++A Y A+ W + P+ + K +S+ Sbjct: 152 DLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYK-FSSK 210 Query: 183 IDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPS 229 D+WS G + E + G+ + G + + + P Sbjct: 211 SDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPR 257 >3LMG-A nrPDB Length = 344 Score = 166 bits (422), Expect = 7e-42, Method: Composition-based stats. Identities = 57/268 (21%), Positives = 103/268 (38%), Gaps = 22/268 (8%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHE----IVALKRVRLDDDDEGVPSSALREICLLKEL 58 + KL+ +G G +GTV K E V +K + + + + + L Sbjct: 32 ELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSF-QAVTDHMLAIGSL 90 Query: 59 KHKNIVRLHDVLHSDKKLTLVFEFCD-QDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFC 117 H +IVRL + L LV ++ L + G L P+++ ++ Q+ KG+ + Sbjct: 91 DHAHIVRLLGLC-PGSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYL 149 Query: 118 HSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCY---SAEVVTLWYRPPDVLF 174 ++HR+L +N+L+ ++++ADFG+A + A+ W + F Sbjct: 150 EEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHF 209 Query: 175 GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLP 234 G Y+ D+WS G EL G + G RL P + P Sbjct: 210 GK--YTHQSDVWSYGVTVWELMTFGAEPYAG----------LRLAEVPDLLEKGERLAQP 257 Query: 235 DYKPYPMYPATTSLVNVVPKLNATGRDL 262 +Y + + T ++L Sbjct: 258 QICTIDVYMVMVKCWMIDENIRPTFKEL 285 >3AOX-A nrPDB Length = 344 Score = 166 bits (420), Expect = 1e-41, Method: Composition-based stats. Identities = 53/290 (18%), Positives = 101/290 (34%), Gaps = 31/290 (10%) Query: 2 QKYEKLEKIGEGTYGTVFKAK-----NRETHEIVALKRVRLDDDDEGVPSSALREICLLK 56 + + +G G +G V++ + N + VA+K + + E L E ++ Sbjct: 47 KNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLP-EVCSEQDELDFLMEALIIS 105 Query: 57 ELKHKNIVRLHDVLHSDKKLTLVFEFC-DQDLKKYFDSCNGD------LDPEIVKSFLFQ 109 + H+NIVR V ++ E DLK + L + Sbjct: 106 KFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARD 165 Query: 110 LLKGLGFCHSRNVLHRDLKPQNLLINRNG---ELKLADFGLARAFGIPVRCYSAEVVTLW 166 + G + + +HRD+ +N L+ G K+ DFG+AR L Sbjct: 166 IACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLP 225 Query: 167 --YRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTE 224 + PP+ ++++ D WS G + E+ + G +P + L+ + Sbjct: 226 VKWMPPEAFMEG-IFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPP 284 Query: 225 EQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNL--LKCNPV 272 + P P+Y T P+ +L+ + +P Sbjct: 285 KNCPG----------PVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPD 324 >5LPZ-A nrPDB Length = 332 Score = 165 bits (419), Expect = 2e-41, Method: Composition-based stats. Identities = 54/207 (26%), Positives = 91/207 (43%), Gaps = 13/207 (6%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 + IG G +G V+KA ++ VA+K++ + E+ + ++KH+N+ Sbjct: 19 FHNDSLIGSGGFGDVYKAILKD-GSAVAIKKLIHVSGQGD--REFMAEMETIGKIKHRNL 75 Query: 64 VRLHDVLHSDKKLTLVFEFCD-QDLKKYF---DSCNGDLDPEIVKSFLFQLLKGLGFCH- 118 V L + LV+EF L+ L+ + +GL F H Sbjct: 76 VPLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHH 135 Query: 119 --SRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCY--SAEVVTLWYRPPDVLF 174 S +++HRD+K N+L++ N E +++DFG+AR S T Y PP+ Sbjct: 136 NCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYYQ 195 Query: 175 GAKLYSTSIDMWSAGCIFAELANAGRP 201 + ST D++S G + EL RP Sbjct: 196 SFR-CSTKGDVYSYGVVLLELLTGKRP 221 >4G3E-A nrPDB Length = 352 Score = 165 bits (419), Expect = 2e-41, Method: Composition-based stats. Identities = 50/200 (25%), Positives = 87/200 (43%), Gaps = 14/200 (7%) Query: 9 KIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHD 68 ++G G++G V + K+++T A+K+VRL+ + E+ L IV L+ Sbjct: 81 RVGRGSFGEVHRMKDKQTGFQCAVKKVRLEVFR-------VEELVACAGLSSPRIVPLYG 133 Query: 69 VLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLK 128 + + + E + G L + +L Q L+GL + H+R +LH D+K Sbjct: 134 AVREGPWVNIFMELLEGGSLGQLIKQMGCLPEDRALYYLGQALEGLEYLHTRRILHGDVK 193 Query: 129 PQNLLINRNG-ELKLADFGLARAFGIPVRCYSAEV-----VTLWYRPPDVLFGAKLYSTS 182 N+L++ +G L DFG A S T + P+V+ G K Sbjct: 194 ADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAPEVVMG-KPCDAK 252 Query: 183 IDMWSAGCIFAELANAGRPL 202 +D+WS+ C+ + N P Sbjct: 253 VDIWSSCCMMLHMLNGCHPW 272 >5LPV-A nrPDB Length = 296 Score = 165 bits (417), Expect = 3e-41, Method: Composition-based stats. Identities = 54/207 (26%), Positives = 91/207 (43%), Gaps = 13/207 (6%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 + IG G +G V+KA ++ VA+K++ + E+ + ++KH+N+ Sbjct: 19 FHNDSLIGSGGFGDVYKAILKD-GSAVAIKKLIHVSGQGD--REFMAEMETIGKIKHRNL 75 Query: 64 VRLHDVLHSDKKLTLVFEFCD-QDLKKYF---DSCNGDLDPEIVKSFLFQLLKGLGFCH- 118 V L + LV+EF L+ L+ + +GL F H Sbjct: 76 VPLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHH 135 Query: 119 --SRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCY--SAEVVTLWYRPPDVLF 174 S +++HRD+K N+L++ N E +++DFG+AR S T Y PP+ Sbjct: 136 NCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYYQ 195 Query: 175 GAKLYSTSIDMWSAGCIFAELANAGRP 201 + ST D++S G + EL RP Sbjct: 196 SFR-CSTKGDVYSYGVVLLELLTGKRP 221 >4LQP-A nrPDB Length = 508 Score = 164 bits (415), Expect = 4e-41, Method: Composition-based stats. Identities = 56/328 (17%), Positives = 114/328 (34%), Gaps = 46/328 (14%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRV-RLDDDDEGVPSSALREICLLKELKH 60 + + ++ IG+G +G V + ++T +I A+K + + + + + E +L Sbjct: 102 EDFHTVKVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKDQLAHVKAERDVLAGSDS 161 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 +V L+ + L L+ EF ++ + ++ + + + H Sbjct: 162 PWVVSLYYSFQDAQYLYLIMEFLPGGDLMTMLIRWQLFTEDVTRFYMAECILAIETIHKL 221 Query: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAFGIP------------VRCYSAEVVTLWYR 168 +HR +KP N+LI+ G +KL+DFGL+ F + Y Sbjct: 222 GFIHRAIKPDNILIDIRGHIKLSDFGLSTGFHKTHDSNYYKKLLQQDEATNGISKPGTYN 281 Query: 169 PPDVLFGAKLYSTSIDMWSAGCIF---------------AELANAGRP--------LFPG 205 K + +D S + G P L+ G Sbjct: 282 ANTTDTANKRQTMVVD--SISLTMSNRQQIQTWRKSRRLMAYSTVGTPDYIAPEIFLYQG 339 Query: 206 NDVDDQLKRIFRLLGTPTEEQWPSMTKLPD--YKPYPMYPATTSLVNVVPKLNATGRDLL 263 + + ++ P ++ P Y+ + T + + ++ DL+ Sbjct: 340 YGQECDWWSLGAIMYECLIGWPPFCSETPQETYRKIMNFEQTLQFPDDI-HISYEAEDLI 398 Query: 264 QNLLKCNPVQRI----SAEEALQHPYFS 287 + LL QR+ A+E HP+F Sbjct: 399 RRLLTH-ADQRLGRHGGADEIKSHPFFR 425 >3UIM-A nrPDB Length = 326 Score = 163 bits (412), Expect = 1e-40, Method: Composition-based stats. Identities = 45/209 (21%), Positives = 87/209 (41%), Gaps = 11/209 (5%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 + +G G +G V+K + +VA+KR++ ++ +G E+ ++ H+ Sbjct: 30 DNFSNKNILGRGGFGKVYKGR-LADGTLVAVKRLK-EERTQGGELQFQTEVEMISMAVHR 87 Query: 62 NIVRLHDVLHSDKKLTLVFEFC-DQDLKKYFDSC---NGDLDPEIVKSFLFQLLKGLGFC 117 N++RL + + LV+ + + + LD + +GL + Sbjct: 88 NLLRLRGFCMTPTERLLVYPYMANGSVASCLRERPESQPPLDWPKRQRIALGSARGLAYL 147 Query: 118 HSR---NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEV-VTLWYRPPDVL 173 H ++HRD+K N+L++ E + DFGLA+ + V T+ + P+ L Sbjct: 148 HDHCDPKIIHRDVKAANILLDEEFEAVVGDFGLAKLMDYKDTHVTTAVRGTIGHIAPEYL 207 Query: 174 FGAKLYSTSIDMWSAGCIFAELANAGRPL 202 K S D++ G + EL R Sbjct: 208 STGKS-SEKTDVFGYGVMLLELITGQRAF 235 >3Q4U-A nrPDB Length = 301 Score = 162 bits (410), Expect = 2e-40, Method: Composition-based stats. Identities = 64/312 (20%), Positives = 111/312 (35%), Gaps = 55/312 (17%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 + LE +G+G YG V++ E VA+K D+ + L +L+ H+ Sbjct: 8 RDITLLECVGKGRYGEVWRGSW--QGENVAVKIFSSRDEKSWFRETELYNTVMLR---HE 62 Query: 62 NIVRLHDVLHSDKK----LTLVFEFCD-QDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGF 116 NI+ + + L L+ + + L Y LD + + GL Sbjct: 63 NILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLT--TLDTVSCLRIVLSIASGLAH 120 Query: 117 CH--------SRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCY----SAEVVT 164 H + HRDLK +N+L+ +NG+ +AD GLA + V T Sbjct: 121 LHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGT 180 Query: 165 LWYRPPDVLFGAKLYS-----TSIDMWSAGCIFAELANA---------GRPLFPGNDVDD 210 Y P+VL +D+W+ G + E+A +P F +D Sbjct: 181 KRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPND 240 Query: 211 QLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCN 270 P+ E + + + P + P L + + L++ N Sbjct: 241 -----------PSFEDMRKVVCVDQQR-----PNIPNRWFSDPTLTSLAK-LMKECWYQN 283 Query: 271 PVQRISAEEALQ 282 P R++A + Sbjct: 284 PSARLTALRIKK 295 >4F0G-A nrPDB Length = 287 Score = 161 bits (409), Expect = 2e-40, Method: Composition-based stats. Identities = 55/273 (20%), Positives = 112/273 (41%), Gaps = 22/273 (8%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVP-----SSALREICLLK 56 + E ++IG+G +G V K + + +VA+K + L D + RE+ ++ Sbjct: 19 NEIEYEKQIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQREVFIMS 78 Query: 57 ELKHKNIVRLHDVLHSDKKLTLVFEFCD-QDLKKYFDSCNGDLDPEIVKSFLFQLLKGLG 115 L H NIV+L+ ++H+ + +V EF DL + + + + G+ Sbjct: 79 NLNHPNIVKLYGLMHNPPR--MVMEFVPCGDLYHRLLDKAHPIKWSVKLRLMLDIALGIE 136 Query: 116 FCHSRN--VLHRDLKPQNLL---INRNGEL--KLADFGLARAFGIPVRCYSAEVVTLWYR 168 + ++N ++HRDL+ N+ ++ N + K+ADFGL++ V S + + Sbjct: 137 YMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQ---SVHSVSGLLGNFQWM 193 Query: 169 PPDVL-FGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLG---TPTE 224 P+ + + Y+ D +S I + P + + + R G T E Sbjct: 194 APETIGAEEESYTEKADTYSFAMILYTILTGEGPFDEYSYGKIKFINMIREEGLRPTIPE 253 Query: 225 EQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNA 257 + P + + + +V +L+ Sbjct: 254 DCPPRLRNVIELCWSGDPKKRPHFSYIVKELSE 286 >2QKW-B nrPDB Length = 321 Score = 159 bits (402), Expect = 1e-39, Method: Composition-based stats. Identities = 57/278 (20%), Positives = 105/278 (37%), Gaps = 23/278 (8%) Query: 10 IGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDV 69 IG G +G V+K R+ VALK R + EI L +H ++V L Sbjct: 47 IGHGVFGKVYKGVLRD-GAKVALK--RRTPESSQGIEEFETEIETLSFCRHPHLVSLIGF 103 Query: 70 LHSDKKLTLVFEFCD-QDLKKYF---DSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHR 125 ++ L++++ + +LK++ D + E +GL + H+R ++HR Sbjct: 104 CDERNEMILIYKYMENGNLKRHLYGSDLPTMSMSWEQRLEICIGAARGLHYLHTRAIIHR 163 Query: 126 DLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEV--VTLWYRPPDVLFGAKLYSTSI 183 D+K N+L++ N K+ DFG+++ + + + V TL Y P+ +L + Sbjct: 164 DVKSINILLDENFVPKITDFGISKKGTELDQTHLSTVVKGTLGYIDPEYFIKGRL-TEKS 222 Query: 184 DMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYP 243 D++S G + E+ A I + L + + Sbjct: 223 DVYSFGVVLFEVLCARS-------------AIVQSLPREMVNLAEWAVESHNNGQLEQIV 269 Query: 244 ATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEAL 281 + P+ D L + R S + L Sbjct: 270 DPNLADKIRPESLRKFGDTAVKCLALSSEDRPSMGDVL 307 >3MDY-A nrPDB Length = 337 Score = 159 bits (402), Expect = 1e-39, Method: Composition-based stats. Identities = 68/303 (22%), Positives = 121/303 (39%), Gaps = 37/303 (12%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 ++ + +++IG+G YG V+ K R E VA+K ++ + + + L++ H+ Sbjct: 37 KQIQMVKQIGKGRYGEVWMGKWR--GEKVAVKVFFTTEEASWFRETEIYQTVLMR---HE 91 Query: 62 NIVRLHDVLHSDK----KLTLVFEFCD-QDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGF 116 NI+ +L L+ ++ + L Y S LD + + + + GL Sbjct: 92 NILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKST--TLDAKSMLKLAYSSVSGLCH 149 Query: 117 CH--------SRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCY----SAEVVT 164 H + HRDLK +N+L+ +NG +AD GLA F + V T Sbjct: 150 LHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGT 209 Query: 165 LWYRPPDVL---FGAKLYSTS--IDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLL 219 Y PP+VL + + DM+S G I E+A G + QL + Sbjct: 210 KRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVS--GGIVEEYQLPYHDLVP 267 Query: 220 GTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEE 279 P+ E + + +P +P S + ++ L+ NP R++A Sbjct: 268 SDPSYEDMREIVCIKKLRP--SFPNRWSSDECLRQMGK----LMTECWAHNPASRLTALR 321 Query: 280 ALQ 282 + Sbjct: 322 VKK 324 >4JLC-A nrPDB Length = 657 Score = 159 bits (402), Expect = 2e-39, Method: Composition-based stats. Identities = 58/244 (23%), Positives = 102/244 (41%), Gaps = 18/244 (7%) Query: 8 EKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLH 67 + +G+G VF+ ++++T ++ A+K V +RE +LK+L HKNIV+L Sbjct: 14 DILGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQ-MREFEVLKKLNHKNIVKLF 72 Query: 68 DVLH--SDKKLTLVFEFCD-QDLKKYFD--SCNGDLDPEIVKSFLFQLLKGLGFCHSRNV 122 + + + L+ EFC L + S L L ++ G+ + Sbjct: 73 AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGI 132 Query: 123 LHRDLKPQNLL--INRNGE--LKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFG--- 175 +HRD+KP N++ I +G+ KL DFG AR + + T Y PD+ Sbjct: 133 VHRDIKPGNIMRVIGEDGQSVYKLTDFGAAREL-EDDEQFVSLYGTEEYLHPDMYERAVL 191 Query: 176 ----AKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMT 231 K Y ++D+WS G F A P P + +++++ + Sbjct: 192 RKDHQKKYGATVDLWSVGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQ 251 Query: 232 KLPD 235 K + Sbjct: 252 KAEN 255 >4EUU-A nrPDB Length = 319 Score = 158 bits (401), Expect = 2e-39, Method: Composition-based stats. Identities = 57/244 (23%), Positives = 102/244 (41%), Gaps = 18/244 (7%) Query: 8 EKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLH 67 + +G+G VF+ ++++T ++ A+K V +RE +LK+L HKNIV+L Sbjct: 15 DILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ-MREFEVLKKLNHKNIVKLF 73 Query: 68 DVLH--SDKKLTLVFEFCD-QDLKKYFD--SCNGDLDPEIVKSFLFQLLKGLGFCHSRNV 122 + + + L+ EFC L + S L L ++ G+ + Sbjct: 74 AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGI 133 Query: 123 LHRDLKPQNLL--INRNGE--LKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFG--- 175 +HR++KP N++ I +G+ KL DFG AR + + T Y PD+ Sbjct: 134 VHRNIKPGNIMRVIGEDGQSVYKLTDFGAAREL-EDDEQFVSLYGTEEYLHPDMYERAVL 192 Query: 176 ----AKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMT 231 K Y ++D+WS G F A P P + +++++ + Sbjct: 193 RKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQ 252 Query: 232 KLPD 235 K + Sbjct: 253 KAEN 256 >4EUT-A nrPDB Length = 396 Score = 158 bits (399), Expect = 4e-39, Method: Composition-based stats. Identities = 57/244 (23%), Positives = 102/244 (41%), Gaps = 18/244 (7%) Query: 8 EKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLH 67 + +G+G VF+ ++++T ++ A+K V +RE +LK+L HKNIV+L Sbjct: 15 DILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ-MREFEVLKKLNHKNIVKLF 73 Query: 68 DVLH--SDKKLTLVFEFCD-QDLKKYFD--SCNGDLDPEIVKSFLFQLLKGLGFCHSRNV 122 + + + L+ EFC L + S L L ++ G+ + Sbjct: 74 AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGI 133 Query: 123 LHRDLKPQNLL--INRNGE--LKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFG--- 175 +HR++KP N++ I +G+ KL DFG AR + + T Y PD+ Sbjct: 134 VHRNIKPGNIMRVIGEDGQSVYKLTDFGAAREL-EDDEQFVSLYGTEEYLHPDMYERAVL 192 Query: 176 ----AKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMT 231 K Y ++D+WS G F A P P + +++++ + Sbjct: 193 RKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQ 252 Query: 232 KLPD 235 K + Sbjct: 253 KAEN 256 >2BUJ-A nrPDB Length = 317 Score = 157 bits (397), Expect = 7e-39, Method: Composition-based stats. Identities = 63/308 (20%), Positives = 115/308 (37%), Gaps = 54/308 (17%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 + Y ++K+GEG + V + ALKR+ + + A RE + + H Sbjct: 29 KHYLFIQKLGEGGFSYVDLVEGLHDGHFYALKRILCHEQQDR--EEAQREADMHRLFNHP 86 Query: 62 NIVRLHDVLHSDK----KLTLVFEFCDQDLK----KYFDSCNGDLDPEIVKSFLFQLLKG 113 NI+RL ++ + L+ F + + L + + L + +G Sbjct: 87 NILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFLTEDQILWLLLGICRG 146 Query: 114 LGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVR---------CYSAEVVT 164 L H++ HRDLKP N+L+ G+ L D G I V ++A+ T Sbjct: 147 LEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSRQALTLQDWAAQRCT 206 Query: 165 LWYRPPDV--LFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTP 222 + YR P++ + + D+WS GC+ + P +F+ + Sbjct: 207 ISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPY----------DMVFQKGDSV 256 Query: 223 TEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQR------IS 276 ++ + P+ ++ LL +++ +P QR +S Sbjct: 257 ALAVQNQLS-----------------IPQSPRHSSALWQLLNSMMTVDPHQRPHIPLLLS 299 Query: 277 AEEALQHP 284 EALQ P Sbjct: 300 QLEALQPP 307 >2WTK-B nrPDB Length = 373 Score = 156 bits (395), Expect = 1e-38, Method: Composition-based stats. Identities = 69/316 (21%), Positives = 117/316 (37%), Gaps = 34/316 (10%) Query: 4 YEKLEKIGEGTYG---TVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 YE L IG+G + TV A+ + T E V ++R+ L+ + + E+ + K H Sbjct: 11 YELLTVIGKG-FEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNH 69 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCN--GDLDPEIVKSFLFQLLKGLGFCH 118 NIV +D +L +V F K + ++ + L +LK L + H Sbjct: 70 PNIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALDYIH 129 Query: 119 SRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVV---------TLWYRP 169 +HR +K ++LI+ +G++ L+ GL + VV L + Sbjct: 130 HMGYVHRSVKASHILISVDGKVYLS--GLRSNLSMISHGQRQRVVHDFPKYSVKVLPWLS 187 Query: 170 PDVLFGA-KLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRI------------- 215 P+VL + Y D++S G ELAN P L+++ Sbjct: 188 PEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPCLLDTSTI 247 Query: 216 --FRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPK-LNATGRDLLQNLLKCNPV 272 L +P+ S P S + + + ++ L+ NP Sbjct: 248 PAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTFSPHFHHFVEQCLQRNPD 307 Query: 273 QRISAEEALQHPYFSD 288 R SA L H +F Sbjct: 308 ARPSASTLLNHSFFKQ 323 >3SV0-A nrPDB Length = 483 Score = 156 bits (395), Expect = 1e-38, Method: Composition-based stats. Identities = 52/212 (24%), Positives = 86/212 (40%), Gaps = 16/212 (7%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 K+ KIG G++G ++ N +T+E VA+K + L E + + L+ Sbjct: 7 NKFRLGRKIGSGSFGEIYLGTNIQTNEEVAIKLENVKTKHP----QLLYESKIYRILQGG 62 Query: 62 -NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 I + LV + L+ F+ C+ L + V Q++ + F HS+ Sbjct: 63 TGIPNVRWFGVEGDYNVLVMDLLGPSLEDLFNFCSRKLSLKTVLMLADQMINRVEFVHSK 122 Query: 121 NVLHRDLKPQNLLIN---RNGELKLADFGLARAF-------GIPVRCYSAEVVTLWYRPP 170 + LHRD+KP N L+ R ++ + DFGLA+ + IP R T Y Sbjct: 123 SFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDTSTHQHIPYRENKNLTGTARYASV 182 Query: 171 DVLFGAKLYSTSIDMWSAGCIFAELANAGRPL 202 + G + S D+ S G + P Sbjct: 183 NTHLGIEQ-SRRDDLESLGYVLMYFLRGSLPW 213 >2Y4I-B nrPDB Length = 319 Score = 155 bits (393), Expect = 2e-38, Method: Composition-based stats. Identities = 60/299 (20%), Positives = 121/299 (40%), Gaps = 37/299 (12%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 ++ E E IG+G +G V+ + H VA++ + ++ D+E + RE+ ++ +H+ Sbjct: 33 EQLEIGELIGKGRFGQVYHGRW---HGEVAIRLIDIERDNEDQLKAFKREVMAYRQTRHE 89 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 N+V S L ++ C L LD + +++KG+G+ H++ Sbjct: 90 NVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAK 149 Query: 121 NVLHRDLKPQNLLINRNGELKLADFGL---ARAFGIPVRCYSAEVVTLW--YRPPDVL-- 173 +LH+DLK +N+ + NG++ + DFGL + R + W + P+++ Sbjct: 150 GILHKDLKSKNVFYD-NGKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAPEIIRQ 208 Query: 174 ------FGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQW 227 +S D+++ G I+ EL P + I +GT + Sbjct: 209 LSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPF-----KTQPAEAIIWQMGTGMKPNL 263 Query: 228 PSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPV--QRISAEEALQHP 284 + + ++ + T L+ +L+ P +R+S HP Sbjct: 264 SQIGMGKEISDILLF-----CWAFEQEERPTFTKLMD-MLEKLPKRNRRLS------HP 310 >5TE0-A nrPDB Length = 347 Score = 155 bits (392), Expect = 2e-38, Method: Composition-based stats. Identities = 62/294 (21%), Positives = 105/294 (35%), Gaps = 57/294 (19%) Query: 8 EKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELK-HKNIVRL 66 E + EG + VF + ALKR+ +++ E REI ++++L HKNIV Sbjct: 25 EVLAEGGFAIVFLVR-TSNGMKCALKRMFVNN--EHDLQVCKREIQIMRDLSGHKNIVGY 81 Query: 67 HDVLHSD------KKLTLVFEFCDQDLKKYF--DSCNGDLDPEIVKSFLFQLLKGLGFCH 118 D ++ ++ ++ +FC V + + H Sbjct: 82 IDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLH 141 Query: 119 SRN--VLHRDLKPQNLLINRNGELKLADFGLAR-AFGIPVRCYSAEV-------VTLWYR 168 ++HRDLK +N+L++ G L DFG A F P V TL YR Sbjct: 142 QCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYR 201 Query: 169 PPDV--LFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQ 226 P++ L+ K+ +T D+W+ GC+ +L P G Sbjct: 202 APEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPF-----------------GESQVAI 244 Query: 227 WPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEA 280 +PD Y L++ +L+ +P +R + Sbjct: 245 CDGNFTIPDNSRYSQDMHC----------------LIRYMLEPDPDKRPDIYQV 282 >6NT9-A nrPDB Length = 742 Score = 155 bits (392), Expect = 3e-38, Method: Composition-based stats. Identities = 57/244 (23%), Positives = 102/244 (41%), Gaps = 18/244 (7%) Query: 8 EKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLH 67 + +G+G VF+ ++++T ++ A+K V +RE +LK+L HKNIV+L Sbjct: 13 DILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ-MREFEVLKKLNHKNIVKLF 71 Query: 68 DVLH--SDKKLTLVFEFCD-QDLKKYFD--SCNGDLDPEIVKSFLFQLLKGLGFCHSRNV 122 + + + L+ EFC L + S L L ++ G+ + Sbjct: 72 AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGI 131 Query: 123 LHRDLKPQNLL--INRNGE--LKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFG--- 175 +HR++KP N++ I +G+ KL DFG AR + + T Y PD+ Sbjct: 132 VHRNIKPGNIMRVIGEDGQSVYKLTDFGAAREL-EDDEQFVSLYGTEEYLHPDMYERAVL 190 Query: 176 ----AKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMT 231 K Y ++D+WS G F A P P + +++++ + Sbjct: 191 RKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQ 250 Query: 232 KLPD 235 K + Sbjct: 251 KAEN 254 >5XD6-A nrPDB Length = 305 Score = 154 bits (391), Expect = 3e-38, Method: Composition-based stats. Identities = 52/214 (24%), Positives = 88/214 (41%), Gaps = 19/214 (8%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 Y IGEG+YG VF + + + A+K++ D + L ++ ++ L+ + Sbjct: 22 DNYGSKSLIGEGSYGRVFYGILK-SGKAAAIKKL---DSSKQPDQEFLAQVSMVSRLRQE 77 Query: 62 NIVRLHDVLHSDKKLTLVFEFC-DQDLKKYFDSCNGD--------LDPEIVKSFLFQLLK 112 N+V L L +E+ + L G L + Sbjct: 78 NVVALLGYCVDGPLRVLAYEYAPNGSLHDILHGRKGVKGAQPGPVLSWHQRVKIAVGAAR 137 Query: 113 GLGFCHSR---NVLHRDLKPQNLLINRNGELKLADFGLARA-FGIPVRCYSAEV-VTLWY 167 GL + H + +V+HRD+K N+L+ + K+ADF L+ + R +S V T Y Sbjct: 138 GLEYLHEKANPHVIHRDIKSSNVLLFDDDVAKIADFDLSNQAPDMAARLHSTRVLGTFGY 197 Query: 168 RPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRP 201 P+ L ST D++S G + EL +P Sbjct: 198 HAPEYAMTGTL-STKSDVYSFGVVLLELLTGRKP 230 >6O8B-A nrPDB Length = 665 Score = 154 bits (391), Expect = 3e-38, Method: Composition-based stats. Identities = 57/244 (23%), Positives = 101/244 (41%), Gaps = 18/244 (7%) Query: 8 EKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLH 67 + +G+G VF+ ++++T ++ A+K V +RE +LK+L HKNIV+L Sbjct: 21 DILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ-MREFEVLKKLNHKNIVKLF 79 Query: 68 DVLH--SDKKLTLVFEFCD-QDLKKYFD--SCNGDLDPEIVKSFLFQLLKGLGFCHSRNV 122 + + + L+ EFC L + S L L ++ G+ + Sbjct: 80 AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGI 139 Query: 123 LHRDLKPQNLL--INRNGE--LKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFG--- 175 +HR++KP N++ I +G+ KL DFG AR + T Y PD+ Sbjct: 140 VHRNIKPGNIMRVIGEDGQSVYKLTDFGAAREL-EDDEQFVELYGTEEYLHPDMYERAVL 198 Query: 176 ----AKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMT 231 K Y ++D+WS G F A P P + +++++ + Sbjct: 199 RKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQ 258 Query: 232 KLPD 235 K + Sbjct: 259 KAEN 262 >3MY0-A nrPDB Length = 305 Score = 154 bits (389), Expect = 5e-38, Method: Composition-based stats. Identities = 60/302 (19%), Positives = 102/302 (33%), Gaps = 43/302 (14%) Query: 6 KLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVR 65 +E +G+G YG V++ E VA+K D+ + + LL+ H NI+ Sbjct: 12 LVECVGKGRYGEVWRGLWH--GESVAVKIFSSRDEQSWFRETEIYNTVLLR---HDNILG 66 Query: 66 LHDVLHSDKK----LTLVFEFCD-QDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCH-- 118 + + L L+ + + L + L+P + GL H Sbjct: 67 FIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQ--TLEPHLALRLAVSAACGLAHLHVE 124 Query: 119 ------SRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCY----SAEVVTLWYR 168 + HRD K +N+L+ N + +AD GLA + V T Y Sbjct: 125 IFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYM 184 Query: 169 PPDVL-FGAKLYSTSI----DMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPT 223 P+VL + D+W+ G + E+A + I P Sbjct: 185 APEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARR-----------TIVNGIVEDYRPPF 233 Query: 224 EEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKC---NPVQRISAEEA 280 + P+ D K T + + L Q + +C NP R++A Sbjct: 234 YDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRI 293 Query: 281 LQ 282 + Sbjct: 294 KK 295 >3SOC-A nrPDB Length = 322 Score = 154 bits (389), Expect = 5e-38, Method: Composition-based stats. Identities = 65/293 (22%), Positives = 108/293 (36%), Gaps = 33/293 (11%) Query: 5 EKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIV 64 + LE G +G V+KA+ +E VA+K + D E+ L +KH+NI+ Sbjct: 27 QLLEVKARGRFGCVWKAQLL--NEYVAVKIFPIQDKQSWQNE---YEVYSLPGMKHENIL 81 Query: 65 RLHDVLHSDK----KLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS- 119 + L L+ F ++ F N + + + +GL + H Sbjct: 82 QFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKAN-VVSWNELCHIAETMARGLAYLHED 140 Query: 120 ---------RNVLHRDLKPQNLLINRNGELKLADFGLARAF--GIPVRCYSAEVVTLWYR 168 + HRD+K +N+L+ N +ADFGLA F G +V T Y Sbjct: 141 IPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYM 200 Query: 169 PPDVLFGAKLYST----SIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTE 224 P+VL GA + IDM++ G + ELA+ D + L Sbjct: 201 APEVLEGAINFQRDAFLRIDMYAMGLVLWELASRC-------TAADGPVDEYMLPFEEEI 253 Query: 225 EQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISA 277 Q PS+ + + + A + ++ + R+SA Sbjct: 254 GQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSA 306 >2CHL-A nrPDB Length = 351 Score = 153 bits (387), Expect = 8e-38, Method: Composition-based stats. Identities = 68/279 (24%), Positives = 109/279 (39%), Gaps = 24/279 (8%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN- 62 + +KIG G +G + KN T+E VA+K L+ P L E K+L + Sbjct: 32 FRVGKKIGCGNFGELRLGKNLYTNEYVAIK---LEPMKSRAPQLHL-EYRFYKQLGSGDG 87 Query: 63 IVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNV 122 I +++ K +V E L+ FD C+ + V QL+ + + HS+N+ Sbjct: 88 IPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNL 147 Query: 123 LHRDLKPQNLLINRNGE-----LKLADFGLARAF-------GIPVRCYSAEVVTLWYRPP 170 ++RD+KP+N LI R G + + DF LA+ + IP R + + T Y Sbjct: 148 IYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSI 207 Query: 171 DVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSM 230 + G K S D+ + G +F P + G D LK ++ +G + Sbjct: 208 NTHLG-KEQSRRDDLEALGHMFMYFLRGSLP-WQGLKA-DTLKERYQKIGDTKRATPIEV 264 Query: 231 --TKLPDYKPYPMYPATTSLVNV--VPKLNATGRDLLQN 265 P+ Y Y L DL Sbjct: 265 LCENFPEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDR 303 >5AR8-A nrPDB Length = 326 Score = 152 bits (385), Expect = 2e-37, Method: Composition-based stats. Identities = 59/292 (20%), Positives = 115/292 (39%), Gaps = 25/292 (8%) Query: 7 LEKIGEGTYGTVFKAKNRETHEIVALKRVRL-DDDDEGVPSSALREICLLKELKHKNIVR 65 L + G GTV A++ + VA+K + + + LRE +L + + I+ Sbjct: 37 LRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILP 96 Query: 66 LHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLD---PEIVKSFLFQLLKGLGFCHSRN- 121 + + + + L +V E+ + + L ++ G+ + H+ Sbjct: 97 ILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTP 156 Query: 122 -VLHRDLKPQNLLINRNGELKLADFGLAR-----AFGIPVRCYSAEVVTLWYRPPDVLF- 174 +LH DLK QN+L++ +K+ADFGL++ + E T+ Y PP+ Sbjct: 157 PLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEP 216 Query: 175 -GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKL 233 S D++S I E+ + +P + + +++ + ++ P + + Sbjct: 217 GQKSRASIKHDIYSYAVITWEVLSRKQPF-------EDVTNPLQIMYSVSQGHRPVINEE 269 Query: 234 PDYKPYPMYPATTSLVNVVPKLNATGR-DLLQNLLKCNPVQR----ISAEEA 280 P SL+ N R L+ L++ PV R I+ EA Sbjct: 270 SLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEA 321 >2H34-A nrPDB Length = 309 Score = 152 bits (384), Expect = 2e-37, Method: Composition-based stats. Identities = 53/222 (23%), Positives = 91/222 (40%), Gaps = 4/222 (1%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLD-DDDEGVPSSALREICLLKELKHKN 62 Y +G G G V++A++ IVALK + D + RE L+ + Sbjct: 36 YRLRRLVGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPVFRTRMQREARTAGRLQEPH 95 Query: 63 IVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNV 122 +V +HD D +L + + G L P + + Q+ L H+ Sbjct: 96 VVPIHDFGEIDGQLYVDMRLINGVDLAAMLRRQGPLAPPRAVAIVRQIGSALDAAHAAGA 155 Query: 123 LHRDLKPQNLLINRNGELKLADFGLARAFGIPV-RCYSAEVVTLWYRPPDVLFGAKLYST 181 HRD+KP+N+L++ + L DFG+A A V TL+Y P+ F + Sbjct: 156 THRDVKPENILVSADDFAYLVDFGIASATTDEKLTQLGNTVGTLYYMAPER-FSESHATY 214 Query: 182 SIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPT 223 D+++ C+ E G P + G+ + I + + P+ Sbjct: 215 RADIYALTCVLYECLT-GSPPYQGDQLSVMGAHINQAIPRPS 255 >3G2F-A nrPDB Length = 336 Score = 151 bits (382), Expect = 3e-37, Method: Composition-based stats. Identities = 67/308 (21%), Positives = 122/308 (39%), Gaps = 42/308 (13%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60 + + LE IG G YG V+K VA+K + + + + L++ H Sbjct: 12 LDNLKLLELIGRGRYGAVYKGS--LDERPVAVKVFSFANRQNFINEKNIYRVPLME---H 66 Query: 61 KNIVRLH---DVLHSDKKL--TLVFEFC-DQDLKKYFDSCNGDLDPEIVKSFLFQLLKGL 114 NI R + + +D ++ LV E+ + L KY D + +GL Sbjct: 67 DNIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTS--DWVSSCRLAHSVTRGL 124 Query: 115 GFCH---------SRNVLHRDLKPQNLLINRNGELKLADFGLARAF--------GIPVRC 157 + H + HRDL +N+L+ +G ++DFGL+ G Sbjct: 125 AYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPGEEDNA 184 Query: 158 YSAEVVTLWYRPPDVLFG------AKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDD- 210 +EV T+ Y P+VL G + +DM++ G I+ E+ LFPG V + Sbjct: 185 AISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVPEY 244 Query: 211 QLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCN 270 Q+ + PT E + K P +P ++ + + ++ +++ + Sbjct: 245 QMAFQTEVGNHPTFEDMQVLVS--REKQRPKFPEAWKENSLAVR---SLKETIEDCWDQD 299 Query: 271 PVQRISAE 278 R++A+ Sbjct: 300 AEARLTAQ 307 >1PY5-A nrPDB Length = 326 Score = 151 bits (382), Expect = 3e-37, Method: Composition-based stats. Identities = 65/299 (21%), Positives = 111/299 (37%), Gaps = 37/299 (12%) Query: 6 KLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVR 65 E IG+G +G V++ K R E VA+K ++ + EI L+H+NI+ Sbjct: 33 LQESIGKGRFGEVWRGKWR--GEEVAVKIFSSREERSWFREA---EIYQTVMLRHENILG 87 Query: 66 LHDVLHSDK----KLTLVFEFCD-QDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCH-- 118 + D +L LV ++ + L Y + + E + GL H Sbjct: 88 FIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRY--TVTVEGMIKLALSTASGLAHLHME 145 Query: 119 ------SRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCY----SAEVVTLWYR 168 + HRDLK +N+L+ +NG +AD GLA + V T Y Sbjct: 146 IVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYM 205 Query: 169 PPDVL---FGAKLYS--TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPT 223 P+VL K + D+++ G +F E+A G D QL + P+ Sbjct: 206 APEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCS--IGGIHEDYQLPYYDLVPSDPS 263 Query: 224 EEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQ 282 E+ + + P + L + +++ N R++A + Sbjct: 264 VEEMRKVVCEQKLR-----PNIPNRWQSCEALRVMAK-IMRECWYANGAARLTALRIKK 316 >5IKW-A nrPDB Length = 310 Score = 150 bits (380), Expect = 5e-37, Method: Composition-based stats. Identities = 66/296 (22%), Positives = 107/296 (36%), Gaps = 56/296 (18%) Query: 5 EKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELK-HKNI 63 E + EG + TVF + ALKR+ +++ + REI ++KEL HKNI Sbjct: 17 TLEESLAEGGFSTVFLVR-THGGIRCALKRMYVNNMPDLNVCK--REITIMKELSGHKNI 73 Query: 64 VRLHDVLHSD-----KKLTLVFEFCDQD--LKKYFDSCNGDLDPEIVKSFLFQLLKGLGF 116 V D + ++ ++ E+C + + V + + Sbjct: 74 VGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVAR 133 Query: 117 CHSRN--VLHRDLKPQNLLINRNGELKLADFGLAR-AFGIPVRCYSAEV-------VTLW 166 H ++HRDLK +N+L+N G L DFG A F P + V TL Sbjct: 134 LHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLS 193 Query: 167 YRPPDV--LFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTE 224 YR P++ L+G K +T D+W+ GC+ +L P G Sbjct: 194 YRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPF-----------------GESQV 236 Query: 225 EQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEA 280 +PD Y L++ +L+ +P R + Sbjct: 237 AICDGNFTIPDNSRYSRNIHC----------------LIRFMLEPDPEHRPDIFQV 276 >6BFN-A nrPDB Length = 342 Score = 150 bits (380), Expect = 6e-37, Method: Composition-based stats. Identities = 59/209 (28%), Positives = 88/209 (42%), Gaps = 20/209 (9%) Query: 9 KIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEG--VPSSALREICLLKELKHKNIVRL 66 KIGEG +G V++A R T + A+KR++ + D E V S L E+ L +H NIV Sbjct: 29 KIGEGGFGCVYRAVMRNT--VYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDF 86 Query: 67 HDVLHSDKKLTLVFEFCDQDLKKYFDSCN----GDLDPEIVKSFLFQLLKGLGFCH--SR 120 + LV+ F + C L L + + F H S Sbjct: 87 AGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSP 146 Query: 121 NVLHRDLKPQNLLINRNGELKLADFGLAR--AFGIPVRCYSAEV-------VTLWYRPPD 171 +++H D+K N+L++ KL DFGLAR F S+ V TL Y P + Sbjct: 147 SLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEE 206 Query: 172 VLFGAKLYSTSIDMWSAGCIFAELANAGR 200 + +L + D +S G + E R Sbjct: 207 YIKTGRL-AVDTDTFSFGVVVLETLAGQR 234 >4M66-A nrPDB Length = 325 Score = 149 bits (377), Expect = 1e-36, Method: Composition-based stats. Identities = 58/274 (21%), Positives = 104/274 (37%), Gaps = 24/274 (8%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 ++ +KLE +G+G +G VF+A +R + VA+K V E+ + L+++ Sbjct: 20 EELKKLEFVGKGGFGVVFRAHHRTWNHDVAVKIVNSKKISW--------EVKAMVNLRNE 71 Query: 62 NIVRLHDVLHSDKK-----LTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGF 116 N++ L V + LV F + ++ L +++ G+ + Sbjct: 72 NVLLLLGVTEDLQWDFVSGQALVTRFMENGSLAGLLQPEAPRPWPLLCRLLQEVVLGMCY 131 Query: 117 CHSRN--VLHRDLKPQNLLINRNGELKLADFGLAR------AFGIPVRCYSAEVVTLWYR 168 HS + +LHRDLKP N+L++ KLADFGL+ + TL Y Sbjct: 132 LHSLDPPLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQSGSGSGSGSRDSGGTLAYL 191 Query: 169 PPDVLFGAK-LYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQW 227 P++LF S + D++S G + + + R P E Sbjct: 192 DPELLFKVNLKASKASDVYSFGILVWAVLAGREAELVDKTSLIRETVCDRQSRPPLTELP 251 Query: 228 PSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRD 261 P + P + + + +D Sbjct: 252 PGSPETPGLEKLKELMIH--CWGSQSENRPSFQD 283 >5FQD-C nrPDB Length = 341 Score = 149 bits (377), Expect = 1e-36, Method: Composition-based stats. Identities = 59/242 (24%), Positives = 93/242 (38%), Gaps = 19/242 (7%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK- 61 KY+ + KIG G++G ++ A N E VA+K L+ P L E L K L+ Sbjct: 20 KYKLVRKIGSGSFGDIYLAINITNGEEVAVK---LESQKARHPQ-LLYESKLYKILQGGV 75 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN 121 I + LV + L+ F+ C+ + V Q++ + + H++N Sbjct: 76 GIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKN 135 Query: 122 VLHRDLKPQNLLINRNGEL---KLADFGLARAF-------GIPVRCYSAEVVTLWYRPPD 171 +HRD+KP N L+ L DFGLA+ + IP R T Y + Sbjct: 136 FIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASIN 195 Query: 172 VLFGAKLYSTSIDMWSAGCIFAELANAGRPL--FPGNDVDDQLKRI-FRLLGTPTEEQWP 228 G + S DM S G + P + ++I + + TP E Sbjct: 196 AHLGIEQ-SRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCK 254 Query: 229 SM 230 Sbjct: 255 GF 256 >2CMW-A nrPDB Length = 310 Score = 149 bits (376), Expect = 2e-36, Method: Composition-based stats. Identities = 63/231 (27%), Positives = 101/231 (43%), Gaps = 21/231 (9%) Query: 5 EKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH--KN 62 +KIG G +G + KN T+E VA+K L+ P L E K+L + Sbjct: 3 RVGKKIGCGNFGELRLGKNLYTNEYVAIK---LEPIKSRAPQLHL-EYRFYKQLGSAGEG 58 Query: 63 IVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNV 122 + +++ K +V E L+ FD C+ + V QLL + + HS+N+ Sbjct: 59 LPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYVHSKNL 118 Query: 123 LHRDLKPQNLLINRNGE-----LKLADFGLARAF-------GIPVRCYSAEVVTLWYRPP 170 ++RD+KP+N LI R G + + DFGLA+ + IP R + + T Y Sbjct: 119 IYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSI 178 Query: 171 DVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGT 221 + G K S D+ + G +F P + G D LK ++ +G Sbjct: 179 NTHLG-KEQSRRDDLEALGHMFMYFLRGSLP-WQGLKA-DTLKERYQKIGD 226 >4TN6-A nrPDB Length = 318 Score = 149 bits (376), Expect = 2e-36, Method: Composition-based stats. Identities = 58/280 (20%), Positives = 102/280 (36%), Gaps = 19/280 (6%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 +Y KIG G++G ++ + E VA+K L+ P + E + K ++ Sbjct: 7 NRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIK---LECVKTKHPQLHI-ESKIYKMMQGG 62 Query: 62 -NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 I + +V E L+ F+ C+ + V Q++ + + HS+ Sbjct: 63 VGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSK 122 Query: 121 NVLHRDLKPQNLLIN---RNGELKLADFGLARAF-------GIPVRCYSAEVVTLWYRPP 170 N +HRD+KP N L+ + + + DFGLA+ + IP R T Y Sbjct: 123 NFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASI 182 Query: 171 DVLFGAKLYSTSIDMWSAG-CIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPS 229 + G + S D+ S G + N G + G + ++ R+ Sbjct: 183 NTHLGIEQ-SRRDDLESLGYVLMY--FNLGSLPWQGLKAATKRQKYERISEKKMSTPIEV 239 Query: 230 MTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKC 269 + K + SL + R L +NL Sbjct: 240 LCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHR 279 >2C47-A nrPDB Length = 313 Score = 148 bits (374), Expect = 3e-36, Method: Composition-based stats. Identities = 64/278 (23%), Positives = 113/278 (40%), Gaps = 23/278 (8%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELK-HKN 62 + +KIG G +G + KN T+E VA+K L+ P L E K+L + Sbjct: 6 FRVGKKIGCGNFGELRLGKNLYTNEYVAIK---LEPIKSRAPQLHL-EYRFYKQLSATEG 61 Query: 63 IVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNV 122 + +++ K +V E L+ FD C+ + V QL+ + + H++++ Sbjct: 62 VPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYVHTKSL 121 Query: 123 LHRDLKPQNLLINRNGE-----LKLADFGLARAF-------GIPVRCYSAEVVTLWYRPP 170 ++RD+KP+N L+ R G + + DFGLA+ + IP R + + T Y Sbjct: 122 IYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSI 181 Query: 171 DVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSM 230 + G K S D+ + G +F P + G D LK ++ +G + Sbjct: 182 NTHLG-KEQSRRDDLEALGHMFMYFLRGSLP-WQGLKA-DTLKERYQKIGDTKRATPIEV 238 Query: 231 TKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLK 268 + Y ++ K + D L+ L Sbjct: 239 LCENFPEEMATYLRYVRRLDFFEKPDY---DYLRKLFT 273 >3QD2-B nrPDB Length = 332 Score = 145 bits (366), Expect = 2e-35, Method: Composition-based stats. Identities = 65/336 (19%), Positives = 117/336 (34%), Gaps = 85/336 (25%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDD------------------- 41 + +E ++ +G G +G VF+AKN+ A+KR+RL + + Sbjct: 5 LTDFEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHP 64 Query: 42 ----------EGVPSSALRE---------------------------ICLLKELKHKNIV 64 E P E I + KN V Sbjct: 65 GIVRYFNAWLETPPEKWQEEMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFSTKNTV 124 Query: 65 RLHDVLHSDKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEI--VKSFLFQLLKGLGFCHSRN 121 L + + C + +LK + + D E Q+ + + F HS+ Sbjct: 125 GQLQPSSPKVYLYIQMQLCRKENLKDWMNRRCSLEDREHGVCLHIFIQIAEAVEFLHSKG 184 Query: 122 VLHRDLKPQNLLINRNGELKLADFGLARAFGIPVR------------CYSAEVVTLWYRP 169 ++HRDLKP N+ + +K+ DFGL A ++ +V T Y Sbjct: 185 LMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQVGTKLYMS 244 Query: 170 PDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPS 229 P+ + G YS +D++S G I EL Q++R+ R++ ++P Sbjct: 245 PEQIHGN-NYSHKVDIFSLGLILFELLY---------SFSTQMERV-RIITDVRNLKFPL 293 Query: 230 MTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQN 265 + K + +++ P D+++N Sbjct: 294 LFT---QKYPQEHMMVQDMLSPSPTERPEATDIIEN 326 >5E8V-A nrPDB Length = 316 Score = 144 bits (365), Expect = 3e-35, Method: Composition-based stats. Identities = 59/296 (19%), Positives = 109/296 (36%), Gaps = 40/296 (13%) Query: 10 IGEGTYGTVFKAKNRETH----EIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVR 65 +G+G + V+KAK ++ E VA+K + E ++I LKH+NI++ Sbjct: 17 VGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYE---EYASWKTEKDIFSDINLKHENILQ 73 Query: 66 LHDVLHSDKKL----TLVFEF-CDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 +L L+ F +L++Y + E ++ L +G+ HS Sbjct: 74 FLTAEERKTELGKQYWLITAFHAKGNLQEYLTRH--VISWEDLRKLGSSLARGIAHLHSD 131 Query: 121 N---------VLHRDLKPQNLLINRNGELKLADFGLARAFG----IPVRCYSAEVVTLWY 167 + ++HRDLK N+L+ + L DFGL+ + S +V T Y Sbjct: 132 HTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARY 191 Query: 168 RPPDVLFGAKLYS-----TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTP 222 P+VL A D++S + E+ + + ++K G+ Sbjct: 192 MAPEVLASAMNLENVESFKQTDVYSMALVLWEMTSRC-------NAVGEVKDYEPPFGSK 244 Query: 223 TEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAE 278 E + + P S + L + +P R++A+ Sbjct: 245 VREHPCVASMADNVLADAGRPEIPSFWLNHQGIQMVCETLTE-CWDHDPEARLTAQ 299 >2QLU-A nrPDB Length = 314 Score = 144 bits (363), Expect = 5e-35, Method: Composition-based stats. Identities = 68/295 (23%), Positives = 111/295 (37%), Gaps = 36/295 (12%) Query: 5 EKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIV 64 + LE G +G V+KA+ VA+K L D REI +KH+N++ Sbjct: 18 QLLEIKARGRFGCVWKAQLMND--FVAVKIFPLQDKQSWQSE---REIFSTPGMKHENLL 72 Query: 65 RLHDVLHSDK----KLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS- 119 + +L L+ F D+ + N + + + +GL + H Sbjct: 73 QFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNI-ITWNELCHVAETMSRGLSYLHED 131 Query: 120 ----------RNVLHRDLKPQNLLINRNGELKLADFGLARAF--GIPVRCYSAEVVTLWY 167 ++ HRD K +N+L+ + LADFGLA F G P +V T Y Sbjct: 132 VPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVGTRRY 191 Query: 168 RPPDVLFGAKLYST----SIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGT-P 222 P+VL GA + IDM++ G + EL + + VD+ + +G P Sbjct: 192 MAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKA--ADGPVDEYMLPFEEEIGQHP 249 Query: 223 TEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISA 277 + E+ + M P P L ++ + R+SA Sbjct: 250 SLEELQEVV-----VHKKMRPTIKDHWLKHPGLAQLCVT-IEECWDHDAEARLSA 298 >5X18-A nrPDB Length = 295 Score = 144 bits (363), Expect = 5e-35, Method: Composition-based stats. Identities = 53/228 (23%), Positives = 90/228 (39%), Gaps = 19/228 (8%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH-KN 62 Y+ +KIGEG++G +F+ N VA+K + E K L N Sbjct: 9 YKIGKKIGEGSFGVLFEGTNMINGVPVAIKFEPRKTEAP----QLRDEYKTYKILNGTPN 64 Query: 63 IVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNV 122 I + LV + L+ FD C + V Q++ + H+ ++ Sbjct: 65 IPYAYYFGQEGLHNILVIDLLGPSLEDLFDWCGRKFSVKTVVQVAVQMITLIEDLHAHDL 124 Query: 123 LHRDLKPQNLLINRNGE-----LKLADFGLARAF-------GIPVRCYSAEVVTLWYRPP 170 ++RD+KP N LI R G+ + L DFG+A+ + IP R + T Y Sbjct: 125 IYRDIKPDNFLIGRPGQPDANNIHLIDFGMAKQYRDPKTKQHIPYREKKSLSGTARYMSI 184 Query: 171 DVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRL 218 + G + S DM + G +F P + G + ++ ++ Sbjct: 185 NTHLGREQ-SRRDDMEALGHVFFYFLRGHLP-WQGLKAPNNKQKYEKI 230 >3VHK-A nrPDB Length = 368 Score = 142 bits (358), Expect = 2e-34, Method: Composition-based stats. Identities = 49/187 (26%), Positives = 84/187 (44%), Gaps = 15/187 (8%) Query: 92 DSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAF 151 D L E + + FQ+ KG+ F SR +HRDL +N+L++ +K+ DFGLAR Sbjct: 191 DLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDI 250 Query: 152 GIPVRC--YSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVD 209 + L + P+ +F ++Y+ D+WS G + E+ + G +PG +D Sbjct: 251 YKDPDYVRKGDARLPLKWMAPETIFD-RVYTIQSDVWSFGVLLWEIFSLGASPYPGVKID 309 Query: 210 DQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQN---L 266 ++ R + + + PDY MY + P T +L+++ L Sbjct: 310 EEFCRRLK---------EGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNL 360 Query: 267 LKCNPVQ 273 L+ N Q Sbjct: 361 LQANAQQ 367 Score = 69.1 bits (168), Expect = 2e-12, Method: Composition-based stats. Identities = 23/107 (21%), Positives = 45/107 (42%), Gaps = 9/107 (8%) Query: 2 QKYEKLEKIGEGTYGTVFKA----KNR-ETHEIVALKRVRLDDDDEGVPSSALREICLLK 56 + + + +G G +G V +A ++ T VA+K ++ + + + E+ +L Sbjct: 29 DRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLK-EGATHSEHRALMSELKILI 87 Query: 57 ELKHK-NIVRLHDVLHS-DKKLTLVFEFCD-QDLKKYFDSCNGDLDP 100 + H N+V L L ++ EFC +L Y S + P Sbjct: 88 HIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVP 134 >5VC6-A nrPDB Length = 289 Score = 141 bits (357), Expect = 2e-34, Method: Composition-based stats. Identities = 62/305 (20%), Positives = 109/305 (35%), Gaps = 60/305 (19%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKEL-KHK 61 ++ +LEKIG G +G+VFK R I A+KR + +ALRE+ L +H Sbjct: 12 EFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHS 71 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGD----LDPEIVKSFLFQLLKGLGFC 117 ++VR D + + E+C+ S N +K L Q+ +GL + Sbjct: 72 HVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYI 131 Query: 118 HSRNVLHRDLKPQNLLINRNGEL-------------------KLADFGLARAFGIPVRCY 158 HS +++H D+KP N+ I+R K+ D G P Sbjct: 132 HSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQVEE 191 Query: 159 SAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRL 218 + +VL + D+++ A PL D ++++ Sbjct: 192 GDS----RFLANEVLQENYTHLPKADIFALALTV-VCAAGAEPLPRNGDQWHEIRQG--- 243 Query: 219 LGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAE 278 L + L+ +LL+ ++ +P +R SA Sbjct: 244 ----------------------------RLPRIPQVLSQEFTELLKVMIHPDPERRPSAM 275 Query: 279 EALQH 283 ++H Sbjct: 276 ALVKH 280 >4NT4-A nrPDB Length = 312 Score = 140 bits (354), Expect = 6e-34, Method: Composition-based stats. Identities = 63/284 (22%), Positives = 109/284 (38%), Gaps = 29/284 (10%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK-- 61 + +KIG G +G + KN +E VA+K + P L E K L Sbjct: 14 FRVGKKIGCGNFGELRLGKNLYNNEHVAIKM---EPMKSKAPQLHL-EYRFYKLLGSHAD 69 Query: 62 ----NIVRLHDVLHSDKKL-TLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGF 116 I R++ + + +V E L+ F+ C + V QLL + + Sbjct: 70 NAPDGIPRIYHLGTCGGRYNAMVLELLGLSLEDLFNICARKFSLKTVLMIAKQLLHRIEY 129 Query: 117 CHSRNVLHRDLKPQNLLINRNGE-----LKLADFGLARAF-------GIPVRCYSAEVVT 164 HSR++++RD+KP+N LI R + + DFGLA+ + IP R + + T Sbjct: 130 VHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRHIPYREHKSLTGT 189 Query: 165 LWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTE 224 Y + G + S D+ + G +F P + G D LK ++ +G Sbjct: 190 ARYMSINTHMGREQ-SRRDDLEALGHMFMYFLRGSLP-WQGLKA-DTLKERYQKIGDTKR 246 Query: 225 EQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLK 268 + + + Y ++ + D L+ L + Sbjct: 247 ATPIEVLCDGHPEEFATYLRYVRRLDFFETPDY---DFLRRLFQ 287 >4XHH-A nrPDB Length = 403 Score = 140 bits (353), Expect = 8e-34, Method: Composition-based stats. Identities = 48/228 (21%), Positives = 88/228 (38%), Gaps = 15/228 (6%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 +K+ KIG G++G ++ N + E VA+ RL+ P Sbjct: 7 RKFRIGRKIGSGSFGDIYHGTNLISGEEVAI---RLESIRSRHPQLDYESRVYKYLSGGV 63 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN 121 I + + +V + L+ F+ C+ + V Q++ + + H R+ Sbjct: 64 GIPFIRWFGREGEYNAMVIDLLGPSLEDLFNYCHRKFSFKTVIMLALQMICRVQYIHGRS 123 Query: 122 VLHRDLKPQNLLIN---RNGELKLADFGLARAF-------GIPVRCYSAEVVTLWYRPPD 171 +HRD+KP N L+ R + + DFGL++ + IP R + T Y + Sbjct: 124 FIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTARYASVN 183 Query: 172 VLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLL 219 G + S D+ S G + P + G + ++ R+L Sbjct: 184 THLGIEQ-SRRDDLESLGYMLIYFCKGSLP-WQGLKATTKKQKYDRIL 229 >3HNG-A nrPDB Length = 360 Score = 139 bits (351), Expect = 1e-33, Method: Composition-based stats. Identities = 46/174 (26%), Positives = 78/174 (44%), Gaps = 12/174 (6%) Query: 95 NGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAF--G 152 + E + S+ FQ+ +G+ F SR +HRDL +N+L++ N +K+ DFGLAR Sbjct: 193 KEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKN 252 Query: 153 IPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQL 212 + L + P+ +F K+YST D+WS G + E+ + G +PG +D+ Sbjct: 253 PDYVRKGDTRLPLKWMAPESIFD-KIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDF 311 Query: 213 KRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNL 266 R + P+Y +Y + PK +L++ L Sbjct: 312 CSRLR---------EGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKL 356 Score = 68.7 bits (167), Expect = 3e-12, Method: Composition-based stats. Identities = 22/105 (20%), Positives = 43/105 (40%), Gaps = 9/105 (8%) Query: 2 QKYEKLEKIGEGTYGTVFKA-----KNRETHEIVALKRVRLDDDDEGVPSSALREICLLK 56 ++ + + +G G +G V +A K T VA+K ++ + + + E+ +L Sbjct: 27 ERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLK-EGATASEYKALMTELKILT 85 Query: 57 ELKHK-NIVRLHDVLHS-DKKLTLVFEFCD-QDLKKYFDSCNGDL 98 + H N+V L L ++ E+C +L Y S Sbjct: 86 HIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKRDLF 130 >4XHL-A nrPDB Length = 394 Score = 138 bits (349), Expect = 2e-33, Method: Composition-based stats. Identities = 47/228 (20%), Positives = 87/228 (38%), Gaps = 15/228 (6%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 +K+ KIG G++G ++ N + E VA+ RL+ P Sbjct: 7 RKFRIGRKIGSGSFGDIYHGTNLISGEEVAI---RLESIRSRHPQLDYESRVYRYLSGGV 63 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN 121 I + + +V + L+ F+ C+ + V Q+ + + H R+ Sbjct: 64 GIPFIRWFGREGEYNAMVIDLLGPSLEDLFNYCHRRFSFKTVIMLALQMFCRIQYIHGRS 123 Query: 122 VLHRDLKPQNLLIN---RNGELKLADFGLARAF-------GIPVRCYSAEVVTLWYRPPD 171 +HRD+KP N L+ R + + DFGL++ + IP R + T Y + Sbjct: 124 FIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTARYASVN 183 Query: 172 VLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLL 219 G + S D+ S G + P + G + ++ R++ Sbjct: 184 THLGIEQ-SRRDDLESLGYVLIYFCKGSLP-WQGLKATTKKQKYDRIM 229 >5VDK-A nrPDB Length = 297 Score = 138 bits (349), Expect = 2e-33, Method: Composition-based stats. Identities = 61/305 (20%), Positives = 114/305 (37%), Gaps = 64/305 (20%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKEL-KH 60 +++ ++EKIG G +GTV+K R + A+KR + +SAL E+ L H Sbjct: 15 KEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSALHEVYAHAVLGHH 74 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGD----LDPEIVKSFLFQLLKGLGF 116 ++VR + D + + E+C+ + S N + +K L Q+ GL + Sbjct: 75 PHVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQISLGLNY 134 Query: 117 CHSRNVLHRDLKPQNL-----------------------LINRNGELKLADFGLARAFGI 153 H+ +++H D+KP N+ ++ N K+ D G A + Sbjct: 135 IHNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIGDLGHATSINK 194 Query: 154 PVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLK 213 P E + ++L + D+++ G A A Sbjct: 195 P----KVEEGDSRFLANEILQEDYRHLPKADIFALGLTIAVAA----------------- 233 Query: 214 RIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQ 273 E P+ + +P +V +L+ + LL+N+++ + Q Sbjct: 234 ---------GAESLPTNGAAWHHIRKGNFP------DVPQELSESFSSLLKNMIQPDAEQ 278 Query: 274 RISAE 278 R SA Sbjct: 279 RPSAA 283 >1CSN-A nrPDB Length = 298 Score = 136 bits (342), Expect = 2e-32, Method: Composition-based stats. Identities = 56/264 (21%), Positives = 92/264 (34%), Gaps = 25/264 (9%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKEL-KHKN 62 Y+ +IGEG++G +F+ N ++ VA+K D E K L Sbjct: 12 YKVGRRIGEGSFGVIFEGTNLLNNQQVAIKFEPRRSDAP----QLRDEYRTYKLLAGCTG 67 Query: 63 IVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNV 122 I ++ LV + L+ D C + V Q+L + H +++ Sbjct: 68 IPNVYYFGQEGLHNVLVIDLLGPSLEDLLDLCGRKFSVKTVAMAAKQMLARVQSIHEKSL 127 Query: 123 LHRDLKPQNLLINRNGE-----LKLADFGLARAF-------GIPVRCYSAEVVTLWYRPP 170 ++RD+KP N LI R + + DFG+ + + IP R T Y Sbjct: 128 VYRDIKPDNFLIGRPNSKNANMIYVVDFGMVKFYRDPVTKQHIPYREKKNLSGTARYMSI 187 Query: 171 DVLFGAKLYSTSIDMWSAGCIFAELANAGRPL--FPGNDVDDQLKRI-FRLLGTPTEEQW 227 + G + S D+ + G +F P + +RI + TP E Sbjct: 188 NTHLGREQ-SRRDDLEALGHVFMYFLRGSLPWQGLKAATNKQKYERIGEKKQSTPLRELC 246 Query: 228 ----PSMTKLPDYKPYPMYPATTS 247 K Y + AT Sbjct: 247 AGFPEEFYKYMHYARNLAFDATPD 270 >5L2Q-C nrPDB Length = 320 Score = 133 bits (334), Expect = 1e-31, Method: Composition-based stats. Identities = 54/303 (17%), Positives = 107/303 (35%), Gaps = 67/303 (22%) Query: 19 FKAKNRETHEIVALKRVRLDDD-DEGVPSSALR--------EICLLKELKHKN-IVRLHD 68 A+ T + LK + L++ D+G+ S R E LL L ++ +V H Sbjct: 33 CLARKDGTDDFYQLKILTLEERGDQGIESQEERQGKMLLHTEYSLLSLLHTQDGVVHHHG 92 Query: 69 VLHS------------------DKKLTLVFE-FCDQDL---------KKYFDSCNGDLDP 100 + K++ LV + C D +++ L Sbjct: 93 LFQDRTCEIVEDTESSRMVKKMKKRICLVLDCLCAHDFSDKTADLINLQHYVIKEKRLSE 152 Query: 101 EIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGE-LKLADFGLARAFGIPVRCYS 159 + +++ + H +N++HRDLK N+++N+ + + +F L + Sbjct: 153 RETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEGDLLK 212 Query: 160 AEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLL 219 + + Y PDVL G DMW+ G + + P + + ++I Sbjct: 213 DQRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPFYDSIP-QELFRKIKAAE 271 Query: 220 GTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEE 279 T E+ +++ L++ LL +P QR++A + Sbjct: 272 YTIPEDG---------------------------RVSENTVCLIRKLLVLDPQQRLAAAD 304 Query: 280 ALQ 282 L+ Sbjct: 305 VLE 307 >4BTK-A nrPDB Length = 337 Score = 132 bits (333), Expect = 1e-31, Method: Composition-based stats. Identities = 54/228 (23%), Positives = 95/228 (41%), Gaps = 18/228 (7%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 +++ L+KIG G +G +++A + T E VALK + + E+ +LK+L+ K Sbjct: 56 DRWKVLKKIGGGGFGEIYEAMDLLTRENVALKV----ESAQQPKQVLKMEVAVLKKLQGK 111 Query: 62 -NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSC-NGDLDPEIVKSFLFQLLKGLGFCHS 119 ++ R ++K +V + ++L S G Q+L+ + HS Sbjct: 112 DHVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHS 171 Query: 120 RNVLHRDLKPQNL----LINRNGELKLADFGLARAFGI------PVRCYSAEVVTLWYRP 169 LHRD+KP N L + + + DFGLAR + P R + T+ Y Sbjct: 172 VGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRYAS 231 Query: 170 PDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFR 217 + ++ D+WS + E A P + +Q+ I Sbjct: 232 VNAHKNREM-GRHDDLWSLFYMLVEFAVGQLP-WRKIKDKEQVGMIKE 277 >4JRN-A nrPDB Length = 372 Score = 132 bits (332), Expect = 2e-31, Method: Composition-based stats. Identities = 64/318 (20%), Positives = 110/318 (34%), Gaps = 77/318 (24%) Query: 10 IGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPS-SALREICLLKELK--------- 59 +G G + TV++A + ET+E +A+K + + RE + Sbjct: 76 LGSGGFATVYEATDVETNEELAVKVFMSEKEPTDETMLDLQRESSCYRNFSLAKTAKDAQ 135 Query: 60 -------HKNIVRLHDVLHSDK-----------KLTLVFEFCDQDLKKYFDSCNG----- 96 ++V L S + L+ + D+ K G Sbjct: 136 ESCRFMVPSDVVMLEGQPASTEVVIGLTTRWVPNYFLLMMRAEADMSKVISWVFGDASVN 195 Query: 97 --DLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIP 154 + + Q +K + ++ ++H D+KP N L+ ++G L L DFG R Sbjct: 196 KSEFGLVVRMYLSSQAIKLVANVQAQGIVHTDIKPANFLLLKDGRLFLGDFGTYRI---- 251 Query: 155 VRCYSAEVVTLWYRPPDVLFGAKL--YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQL 212 + T Y PP+ F A Y+ D W G + RP Sbjct: 252 NNSVGRAIGTPGYEPPERPFQATGITYTFPTDAWQLGITLYCIWCKERP----------- 300 Query: 213 KRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPV 272 TP + W DY + P+T LV +DL+++LL +P Sbjct: 301 --------TPADGIW-------DYLHFADCPSTPELV----------QDLIRSLLNRDPQ 335 Query: 273 QRISAEEALQHPYFSDFC 290 +R+ +AL+ F + Sbjct: 336 KRMLPLQALETAAFKEMD 353 >4NFN-A nrPDB Length = 309 Score = 131 bits (330), Expect = 3e-31, Method: Composition-based stats. Identities = 54/228 (23%), Positives = 95/228 (41%), Gaps = 18/228 (7%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 +++ L+KIG G +G +++A + T E VALK + + E+ +LK+L+ K Sbjct: 21 DRWKVLKKIGGGGFGEIYEAMDLLTRENVALKV----ESAQQPKQVLKMEVAVLKKLQGK 76 Query: 62 -NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSC-NGDLDPEIVKSFLFQLLKGLGFCHS 119 ++ R ++K +V + ++L S G Q+L+ + HS Sbjct: 77 DHVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHS 136 Query: 120 RNVLHRDLKPQNL----LINRNGELKLADFGLARAFGI------PVRCYSAEVVTLWYRP 169 LHRD+KP N L + + + DFGLAR + P R + T+ Y Sbjct: 137 VGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRYAS 196 Query: 170 PDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFR 217 + ++ D+WS + E A P + +Q+ I Sbjct: 197 VNAHKNREM-GRHDDLWSLFYMLVEFAVGQLP-WRKIKDKEQVGMIKE 242 >4RT7-A nrPDB Length = 415 Score = 131 bits (329), Expect = 4e-31, Method: Composition-based stats. Identities = 53/221 (23%), Positives = 93/221 (42%), Gaps = 19/221 (8%) Query: 50 REICLLKELKHKNIVRLHD-VLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLF 108 RE+ + + I LH HS+ ++ E+ +Q + + N L E + F + Sbjct: 198 REVQIHPDSDQ--ISGLHGNSFHSEDEI----EYENQKRLEEEEDLN-VLTFEDLLCFAY 250 Query: 109 QLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRC--YSAEVVTLW 166 Q+ KG+ F ++ +HRDL +N+L+ +K+ DFGLAR + + Sbjct: 251 QVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVK 310 Query: 167 YRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFR------LLG 220 + P+ LF +Y+ D+WS G + E+ + G +PG VD ++ + Sbjct: 311 WMAPESLFEG-IYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPF 369 Query: 221 TPTEEQWPSMTKLP--DYKPYPMYPATTSLVNVVPKLNATG 259 TEE + M D + P +P TS + Sbjct: 370 YATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEA 410 Score = 80.7 bits (198), Expect = 7e-16, Method: Composition-based stats. Identities = 25/104 (24%), Positives = 43/104 (41%), Gaps = 8/104 (7%) Query: 2 QKYEKLEKIGEGTYGTVFKAK-----NRETHEIVALKRVRLDDDDEGVPSSALREICLLK 56 + E + +G G +G V A VA+K ++ + D + + E+ ++ Sbjct: 65 ENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLK-EKADSSEREALMSELKMMT 123 Query: 57 EL-KHKNIVRLHDVLHSDKKLTLVFEF-CDQDLKKYFDSCNGDL 98 +L H+NIV L + L+FE+ C DL Y S Sbjct: 124 QLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKF 167 >5J0A-A nrPDB Length = 300 Score = 130 bits (327), Expect = 8e-31, Method: Composition-based stats. Identities = 55/299 (18%), Positives = 110/299 (36%), Gaps = 37/299 (12%) Query: 7 LEKIGEGTYGT---VFKAKNRE---THEIVALKRVRL---DDDDEGVPSSALREICLLKE 57 ++K+G +GT V+ K +H A+K++ D + E +LK Sbjct: 14 MQKLG---FGTGVNVYLMKRSPRGLSHSPWAVKKINPICNDHYRSVYQKRLMDEAKILKS 70 Query: 58 LKHKNIVRLHDVLH-SDKKLTLVFEFC-DQDLKKYFDSC----NGDLDPEIVKSFLFQLL 111 L H NIV +D L L E+ ++ L + I+ + Sbjct: 71 LHHPNIVGYRAFTEANDGSLCLAMEYGGEKSLNDLIEERYKASQDPFPAAIILKVALNMA 130 Query: 112 KGLGFCH-SRNVLHRDLKPQNLLINRNG-ELKLADFGLARAFGIPVRCYSAE---VVTLW 166 +GL + H + +LH D+K N++I + +K+ D G++ + E + T Sbjct: 131 RGLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMEVTDPEACYIGTEP 190 Query: 167 YRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQ 226 ++P + + + + D+++ G E+ P ++ DD + F E Sbjct: 191 WKPKEAVEENGVITDKADIFAFGLTLWEMMTLSIPHINLSNDDDDEDKTFDESDFDDEAY 250 Query: 227 WPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAE---EALQ 282 + ++ P + + ++ + +P R SA EAL+ Sbjct: 251 YAALGTRPPINMEELDESYQKVIELFSVCTNE-----------DPKDRPSAAHIVEALE 298 >6DC0-A nrPDB Length = 292 Score = 129 bits (325), Expect = 1e-30, Method: Composition-based stats. Identities = 53/273 (19%), Positives = 94/273 (34%), Gaps = 41/273 (15%) Query: 18 VFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLT 77 V +A T + K + + + ++ H NI + +V+ + K Sbjct: 22 VSRALCIHTGRELRCKVFPIKHYQDKIRP-------YIQLPSHSNITGIVEVILGETKAY 74 Query: 78 LVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLIN-- 135 + FE D+ Y S L E Q++ + CH ++ DLK + + + Sbjct: 75 VFFEKDFGDMHSYVRSRK-RLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTE 133 Query: 136 RNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYS-TSIDMWSAGCIFAE 194 +L+L S + Y P++L YS + D+WS G + Sbjct: 134 ERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYT 193 Query: 195 LANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPK 254 L P F +D +I R E Sbjct: 194 LLVGRYP-FHDSDPSALFSKIRRGQFCIPE-----------------------------H 223 Query: 255 LNATGRDLLQNLLKCNPVQRISAEEALQHPYFS 287 ++ R L+++LL+ P +R++A E L HP+F Sbjct: 224 ISPKARCLIRSLLRREPSERLTAPEILLHPWFE 256 >5CEK-A nrPDB Length = 263 Score = 129 bits (325), Expect = 1e-30, Method: Composition-based stats. Identities = 53/273 (19%), Positives = 94/273 (34%), Gaps = 41/273 (15%) Query: 18 VFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLT 77 V +A T + K + + + ++ H NI + +V+ + K Sbjct: 25 VSRALCIHTGRELRCKVFPIKHYQDKIRP-------YIQLPSHSNITGIVEVILGETKAY 77 Query: 78 LVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLIN-- 135 + FE D+ Y S L E Q++ + CH ++ DLK + + + Sbjct: 78 VFFEKDFGDMHSYVRSRK-RLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTE 136 Query: 136 RNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYS-TSIDMWSAGCIFAE 194 +L+L S + Y P++L YS + D+WS G + Sbjct: 137 ERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYT 196 Query: 195 LANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPK 254 L P F +D +I R E Sbjct: 197 LLVGRYP-FHDSDPSALFSKIRRGQFCIPE-----------------------------H 226 Query: 255 LNATGRDLLQNLLKCNPVQRISAEEALQHPYFS 287 ++ R L+++LL+ P +R++A E L HP+F Sbjct: 227 ISPKARCLIRSLLRREPSERLTAPEILLHPWFE 259 >5X1R-A nrPDB Length = 302 Score = 129 bits (324), Expect = 2e-30, Method: Composition-based stats. Identities = 48/289 (16%), Positives = 98/289 (33%), Gaps = 35/289 (12%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKR-----VRLDDDD--------------E 42 ++E E IGEG +G V++A + + +A+K + +DD + Sbjct: 21 NEFEIQEAIGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAKRNDDLSIGLRGERFGKTFQ 80 Query: 43 GVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGD-LDPE 101 +S ++E LL H ++ + + + +F K + + +D Sbjct: 81 AGLNSFIQEARLLARFSHPGLLHVLRFWEENGTAYMGTQFYSGTTLKNLQAQQPEKIDEA 140 Query: 102 IVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAE 161 ++ L L + H LHRD+ N+ I + L DFG AR + + Sbjct: 141 WIRRLLPPLFSAINTIHQEGYLHRDISLDNIQIQESQLPVLLDFGSARKEIGNLSDETEI 200 Query: 162 VVTLWYRPPDVL--FGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLL 219 V+ + P + D+++ G + L P ++ Sbjct: 201 VLKPGFAPIEQYTENSDGEQGPWTDIYALGAVLHTLIVGSPPP-------------VSVV 247 Query: 220 GTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLK 268 + + P + P + + + P+ D + LL+ Sbjct: 248 RSIEDSYQPLTERRPAGYSPELLRTVDRALALKPEDRPQTIDEMAELLE 296 >5USZ-A nrPDB Length = 289 Score = 128 bits (321), Expect = 4e-30, Method: Composition-based stats. Identities = 57/291 (19%), Positives = 101/291 (34%), Gaps = 52/291 (17%) Query: 8 EKIGEGTYGTVFKAKNRETHE-------IVALKRVRLDDDDEGVPSSALREICLLKELKH 60 E +G+GT+ +FK RE + V LK + D S ++ +L H Sbjct: 14 ESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVL--DKAHRNYSESFFEAASMMSKLSH 71 Query: 61 KNIVRLHDVLHSDKKLTLVFEFCD-QDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 K++V + V + LV EF L Y ++ QL + F Sbjct: 72 KHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAAAMHFLEE 131 Query: 120 RNVLHRDLKPQNLLINRNGE--------LKLADFGLARAFGIPVRCYSAEVVTLWYRPPD 171 ++H ++ +N+L+ R + +KL+D G++ +P + + PP+ Sbjct: 132 NTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITV-LPKDILQERIP---WVPPE 187 Query: 172 VLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMT 231 + K + + D WS G E+ + G D Sbjct: 188 CIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQ---------------------R 226 Query: 232 KLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQ 282 KL Y+ PA + A +L+ N + P R S ++ Sbjct: 227 KLQFYEDRHQLPAPKA---------AELANLINNCMDYEPDHRPSFRAIIR 268 >2PZI-A nrPDB Length = 681 Score = 127 bits (320), Expect = 5e-30, Method: Composition-based stats. Identities = 58/283 (20%), Positives = 103/283 (36%), Gaps = 52/283 (18%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRE-THEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 +YE I G G ++ A +R V LK + + D + A+ E L E+ H Sbjct: 81 QYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGL-VHSGDAEAQAMAMAERQFLAEVVHP 139 Query: 62 NIVRLHDVLHSDKKL-----TLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGF 116 +IV++ + + + +V E+ K S L ++L ++L L + Sbjct: 140 SIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSLK--RSKGQKLPVAEAIAYLLEILPALSY 197 Query: 117 CHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGA 176 HS +++ DLKP+N+++ +LKL D G Y T ++ P+++ Sbjct: 198 LHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINSFGYLY----GTPGFQAPEIVRTG 252 Query: 177 KLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDY 236 + + D+++ G A L P G VD E P + Y Sbjct: 253 P--TVATDIYTVGRTLAAL-TLDLPTRNGRYVD------------GLPEDDPVLKTYDSY 297 Query: 237 KPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEE 279 LL+ + +P QR + E Sbjct: 298 GR-----------------------LLRRAIDPDPRQRFTTAE 317 >4L00-A nrPDB Length = 304 Score = 127 bits (319), Expect = 7e-30, Method: Composition-based stats. Identities = 53/292 (18%), Positives = 101/292 (34%), Gaps = 50/292 (17%) Query: 7 LEKIGEGTYGTVFKAK------NRETHEIVALKRVR--LDDDDEGVPSSALREICLLKEL 58 E +G GT ++ + T E +K + LD + + +++++ Sbjct: 30 GEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQV 89 Query: 59 KHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGD-LDPEIVKSFLFQLLKGLGFC 117 HK+IV L+ V D + +V EF + F D L QL L + Sbjct: 90 SHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYL 149 Query: 118 HSRNVLHRDLKPQNLLINRNGE-------LKLADFGLARAFGIPVRCYSAEVVTLWYRPP 170 ++++H ++ +NLL+ R G +KL+D G I V + + + P Sbjct: 150 EDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPG----IPITVLSRQECIERIPWIAP 205 Query: 171 DVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSM 230 + + +K S + D WS G E+ G + ++ +R + P + Sbjct: 206 ECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEK-ERFYESRCRPVTPSCKEL 264 Query: 231 TKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQ 282 DL+ + +P QR ++ Sbjct: 265 A-----------------------------DLMTRCMNYDPNQRPFFRAIMR 287 >4Y12-A nrPDB Length = 375 Score = 125 bits (315), Expect = 2e-29, Method: Composition-based stats. Identities = 58/283 (20%), Positives = 103/283 (36%), Gaps = 52/283 (18%) Query: 3 KYEKLEKIGEGTYGTVFKAKNRE-THEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 +YE I G G ++ A +R V LK + + D + A+ E L E+ H Sbjct: 120 QYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGL-VHSGDAEAQAMAMAERQFLAEVVHP 178 Query: 62 NIVRLHDVLHSDKKL-----TLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGF 116 +IV++ + + + +V E+ K S L ++L ++L L + Sbjct: 179 SIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSLK--RSKGQKLPVAEAIAYLLEILPALSY 236 Query: 117 CHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGA 176 HS +++ DLKP+N+++ +LKL D G Y T ++ P+++ Sbjct: 237 LHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINSFGYLY----GTPGFQAPEIVRTG 291 Query: 177 KLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDY 236 + + D+++ G A L P G VD E P + Y Sbjct: 292 P--TVATDIYTVGRTLAAL-TLDLPTRNGRYVD------------GLPEDDPVLKTYDSY 336 Query: 237 KPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEE 279 LL+ + +P QR + E Sbjct: 337 GR-----------------------LLRRAIDPDPRQRFTTAE 356 >4M69-B nrPDB Length = 283 Score = 123 bits (309), Expect = 1e-28, Method: Composition-based stats. Identities = 48/278 (17%), Positives = 93/278 (33%), Gaps = 41/278 (14%) Query: 16 GTVFKAKNRETHEIVALKRVRLDDDDE--GVPSSALREICLLKELKHKNIVRLHDVLHSD 73 T+++ + + V +K + V + EI +K+ NI+R+ + Sbjct: 23 STIYRGEYHRS--PVTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICIDQ 80 Query: 74 K----KLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKP 129 + ++V E+C+ + DL + + + +GL H LHR++ Sbjct: 81 TVKPPEFSIVMEYCELGTLRELLDREKDLTMSVRSLLVLRAARGLYRLHHSETLHRNISS 140 Query: 130 QNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLW----YRPPDVLFGA-KLYSTSID 184 + L+ ++KLA F L++ R + Y P+ L LY + Sbjct: 141 SSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDIKAE 200 Query: 185 MWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPA 244 ++S G + E+A P F G D + + Sbjct: 201 IYSFGIVLWEIATGKIP-FEGCDSKKIRELVAE--------------------------- 232 Query: 245 TTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQ 282 V R+++ P QR S + L+ Sbjct: 233 DKKQEPVGQDCPELLREIINECRAHEPSQRPSVDGILE 270 >4BTF-A nrPDB Length = 469 Score = 123 bits (308), Expect = 1e-28, Method: Composition-based stats. Identities = 48/278 (17%), Positives = 93/278 (33%), Gaps = 41/278 (14%) Query: 16 GTVFKAKNRETHEIVALKRVRLDDDDE--GVPSSALREICLLKELKHKNIVRLHDVLHSD 73 T+++ + + V +K + V + EI +K+ NI+R+ + Sbjct: 209 STIYRGEYHRS--PVTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICIDQ 266 Query: 74 K----KLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKP 129 + ++V E+C+ + DL + + + +GL H LHR++ Sbjct: 267 TVKPPEFSIVMEYCELGTLRELLDREKDLTMSVRSLLVLRAARGLYRLHHSETLHRNISS 326 Query: 130 QNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLW----YRPPDVLFGA-KLYSTSID 184 + L+ ++KLA F L++ R + Y P+ L LY + Sbjct: 327 SSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDIKAE 386 Query: 185 MWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPA 244 ++S G + E+A P F G D + + Sbjct: 387 IYSFGIVLWEIATGKIP-FEGCDSKKIRELVAE--------------------------- 418 Query: 245 TTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQ 282 V R+++ P QR S + L+ Sbjct: 419 DKKQEPVGQDCPELLREIINECRAHEPSQRPSVDGILE 456 >4MWI-A nrPDB Length = 294 Score = 119 bits (298), Expect = 2e-27, Method: Composition-based stats. Identities = 53/281 (18%), Positives = 99/281 (35%), Gaps = 45/281 (16%) Query: 16 GTVFKAKNRETHEIVALKRVRLDDDDEG--VPSSALREICLLKELKHKNIVRLHDVLHSD 73 T++K + VA+K + V + +EI +K+ + NI+R+ + + Sbjct: 38 STLYKGEYHR--APVAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICIDE 95 Query: 74 K----KLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNV--LHRDL 127 + ++V E+C+ + DL + +GL H LH + Sbjct: 96 TVTPPQFSIVMEYCELGTLRELLDREKDLTLGKRMVLVLGAARGLYRLHHSEAPELHGKI 155 Query: 128 KPQNLLINRNGELKLADFGLARAFGI----PVRCYSAEVVTLWYRPPDVLFGAKL-YSTS 182 + N L+ + ++KLA F L + R + V + Y P L Y Sbjct: 156 RSSNFLVTQGYQVKLAGFELRKTQTSMSLGTTREKTDRVKSTAYLSPQELEDVFYQYDVK 215 Query: 183 IDMWSAGCIFAELANAGRPLFPGNDVDDQLKRI-FRLLGTPTEEQWPSMTKLPDYKPYPM 241 +++S G + E+A P F G + + K + + P E PS Sbjct: 216 SEIYSFGIVLWEIATGDIP-FQGCNSEKIRKLVAVKRQQEPLGEDCPS------------ 262 Query: 242 YPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQ 282 R+++ +P R S +E L+ Sbjct: 263 ----------------ELREIIDECRAHDPSVRPSVDEILK 287 >5C01-A nrPDB Length = 342 Score = 115 bits (289), Expect = 2e-26, Method: Composition-based stats. Identities = 48/271 (17%), Positives = 89/271 (32%), Gaps = 45/271 (16%) Query: 21 AKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVF 80 ++R V LK + D + + L+ ++ H ++ +H V + +V Sbjct: 101 GRDRGQELRVVLKVL--DPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVT 158 Query: 81 EFCDQDLKK-YFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGE 139 E+ + + G + QL L + ++N++H ++ +N+L+ R G Sbjct: 159 EYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGL 218 Query: 140 -------LKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVL-FGAKLYSTSIDMWSAGCI 191 +KL+D G G+ V + + P+ L GA ST++D W G Sbjct: 219 AEGTSPFIKLSDPG----VGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGAT 274 Query: 192 FAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNV 251 E+ G ++ + P P P + Sbjct: 275 LLEICFDGEAPLQSRSPSEK----------------EHFYQRQHRLPEPSCPQLAT---- 314 Query: 252 VPKLNATGRDLLQNLLKCNPVQRISAEEALQ 282 L L P QR S L+ Sbjct: 315 ----------LTSQCLTYEPTQRPSFRTILR 335 >4WOV-A nrPDB Length = 317 Score = 114 bits (286), Expect = 4e-26, Method: Composition-based stats. Identities = 48/271 (17%), Positives = 89/271 (32%), Gaps = 45/271 (16%) Query: 21 AKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVF 80 ++R V LK + D + + L+ ++ H ++ +H V + +V Sbjct: 78 GRDRGQELRVVLKVL--DPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVT 135 Query: 81 EFCDQDLKK-YFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGE 139 E+ + + G + QL L + ++N++H ++ +N+L+ R G Sbjct: 136 EYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGL 195 Query: 140 -------LKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVL-FGAKLYSTSIDMWSAGCI 191 +KL+D G G+ V + + P+ L GA ST++D W G Sbjct: 196 AEGTSPFIKLSDPG----VGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGAT 251 Query: 192 FAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNV 251 E+ G ++ + P P P + Sbjct: 252 LLEICFDGEAPLQSRSPSEK----------------EHFYQRQHRLPEPSCPQLAT---- 291 Query: 252 VPKLNATGRDLLQNLLKCNPVQRISAEEALQ 282 L L P QR S L+ Sbjct: 292 ----------LTSQCLTYEPTQRPSFRTILR 312 >5M07-A nrPDB Length = 276 Score = 114 bits (285), Expect = 5e-26, Method: Composition-based stats. Identities = 44/205 (21%), Positives = 79/205 (38%), Gaps = 22/205 (10%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDD-DEGVPSSALREICLLKELKHKN 62 Y + +G G V+ ++ ALK + D+ RE + L H + Sbjct: 32 YTVVRMLGASAMGEVYLVQHPGFPGWQALKVLSPAMAADDEFRRRFQRETEVAARLFHPH 91 Query: 63 IVRLHDVLHSDKKLTLVFEFCDQ-DLKKYF-DSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 I+ +HD D +L + ++ D D ++ D L V + + + L + H R Sbjct: 92 ILEVHDRGEFDGQLWIAMDYVDGIDATQHMADRFPAVLPVGEVLAIVTAVAGALDYAHQR 151 Query: 121 NVLHRDLKPQNLLINR----NGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGA 176 +LHRD+ P N+++ + + LADFG+A Y P++ GA Sbjct: 152 GLLHRDVNPANVVLTSQSAGDQRILLADFGIASQ--------------PSYPAPELSAGA 197 Query: 177 KLYSTSIDMWSAGCIFAELANAGRP 201 + + D ++ L P Sbjct: 198 DVDGRA-DQYALALTAIHLFAGAPP 221 >4L68-A nrPDB Length = 340 Score = 111 bits (278), Expect = 4e-25, Method: Composition-based stats. Identities = 43/191 (22%), Positives = 77/191 (40%), Gaps = 13/191 (6%) Query: 16 GTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKK 75 GT +KA +A+K + E E+ L EL+H N+ L +++ Sbjct: 54 GTTYKA-LLPDGSALAVKHLSTCKLGE---REFRYEMNQLWELRHSNLAPLLGFCVVEEE 109 Query: 76 LTLVFEFC-DQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCH---SRNVLHRDLKPQN 131 LV+++ + L DS G+LD +GL + H +LH+++ Sbjct: 110 KFLVYKYMSNGTLHSLLDSNRGELDWSTRFRIGLGAARGLAWLHHGCRPPILHQNICSSV 169 Query: 132 LLINRNGELKLADFGLARAF----GIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWS 187 +LI+ + + ++ D GLAR + ++ Y P+ L S D++ Sbjct: 170 ILIDEDFDARIIDSGLARLMVPSDNNESSFMTGDLGEFGYVAPE-YSTTMLASLKGDVYG 228 Query: 188 AGCIFAELANA 198 G + ELA Sbjct: 229 LGVVLLELATG 239 >3REP-A nrPDB Length = 271 Score = 99.5 bits (247), Expect = 2e-21, Method: Composition-based stats. Identities = 44/270 (16%), Positives = 92/270 (34%), Gaps = 47/270 (17%) Query: 16 GTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDK- 74 G ++K + + +V K +++ D E L+ H N++ + S Sbjct: 24 GELWKGRWQGNDIVV--KVLKVRDWSTRKSRDFNEECPRLRIFSHPNVLPVLGACQSPPA 81 Query: 75 -KLTLVFEFCD-QDLKKYFDS-CNGDLDPEIVKSFLFQLLKGLGFCHS-RNVLHR-DLKP 129 TL+ + L N +D F + +G+ F H+ ++ R L Sbjct: 82 PHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFLHTLEPLIPRHALNS 141 Query: 130 QNLLINRNGELKL--ADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYS--TSIDM 185 ++++I+ + ++ AD + F P R Y+ + P+ L + S DM Sbjct: 142 RSVMIDEDMTARISMADVKFS--FQSPGRMYA-----PAWVAPEALQKKPEDTNRRSADM 194 Query: 186 WSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT 245 WS + EL P ++++ +K L Sbjct: 195 WSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRP------------------------ 230 Query: 246 TSLVNVVPKLNATGRDLLQNLLKCNPVQRI 275 + P ++ L++ + +P +R Sbjct: 231 ----TIPPGISPHVSKLMKICMNEDPAKRP 256 >4I94-A nrPDB Length = 300 Score = 97.6 bits (242), Expect = 5e-21, Method: Composition-based stats. Identities = 42/259 (16%), Positives = 93/259 (35%), Gaps = 19/259 (7%) Query: 17 TVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKL 76 V+K K E +A+KR L E + +L++ + L + D++ Sbjct: 44 VVYKGK-LENQRRIAVKRFNRKS--WPDSRQFLEEAKAVGQLRNHRMANLLGCCYEDEER 100 Query: 77 TLVFEFCDQDLK--KYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN-VLHRDLKPQNLL 133 L+ EF + F + + + + + L +C S+ L+ DL +L Sbjct: 101 LLIAEFMPNETLAKHLFHWESQPMKWAMRLRVALHIAQALEYCTSKGRALYHDLNAYRVL 160 Query: 134 INRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFA 193 + + +L+ FGL + + T PP+ L ++ + ++S G + Sbjct: 161 FDDDANPRLSCFGLMKNSRDGKSYSTNLAFT----PPEYLRTGRV-TPESVIYSFGTLLL 215 Query: 194 ELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVP 253 +L + + + I L+ + E Q+ S + + + P Sbjct: 216 DLLSGKHIPPSHALDLIRDRNIQMLMDSGLEGQFSS------DDGTELIRLASRCLQYEP 269 Query: 254 KLNATGRDLLQNL--LKCN 270 + + L+ + L+ + Sbjct: 270 RERPNPKSLVSAMIPLQKD 288 >5OAT-A nrPDB Length = 411 Score = 97.2 bits (241), Expect = 7e-21, Method: Composition-based stats. Identities = 62/340 (18%), Positives = 112/340 (32%), Gaps = 96/340 (28%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHE-----IVALKRV---RLDDDDEGVPSSALREI 52 + + I +GT G V+ AK ++ ALK + + ++ + + RE Sbjct: 10 LNDLSLGKPIAKGTNGVVYSAKVKDDETDDNKYPFALKMMFNYDIQENSMEILKAMYRET 69 Query: 53 CLLKELK---------------------HKNIVRLHDVLHS-----------------DK 74 + H NIV + V + Sbjct: 70 VPARMYYSNHDLNNWEIELANRRKHLPPHPNIVAIFSVFTDLYPAALPPRLHPEGEGRNM 129 Query: 75 KLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLI 134 L L+ + D +L+ + + ++ + L + G+ + + HRDLK NLL+ Sbjct: 130 SLFLLMKRYDCNLQSFLSTAPSTRTSLLLLAQLLE---GVAHMTAHGIAHRDLKSDNLLL 186 Query: 135 N----RNGELKLADFGLA-----RAFGIPVRCYS-AEVVTLWYRPPDVLFGAK------L 178 + + L ++DFG +P Y + P+++ Sbjct: 187 DTSEPESPILVISDFGCCLADKTNGLSLPYTSYEMDKGGNTALMAPEIICQKPGTFSVLN 246 Query: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKP 238 YS D+W+ G I E+ N P + PS K +YK Sbjct: 247 YS-KADLWAVGAIAYEIFNCHNPFY-----------------------GPSRLKNFNYKE 282 Query: 239 YPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAE 278 L + ++ + L+ NLLK NP +R+ E Sbjct: 283 -------GDLPKLPDEVPTVIQALVANLLKRNPNKRLDPE 315 >6J6I-B nrPDB Length = 351 Score = 97.2 bits (241), Expect = 7e-21, Method: Composition-based stats. Identities = 34/198 (17%), Positives = 68/198 (34%), Gaps = 14/198 (7%) Query: 27 HEIVALKRVRLDD---DDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFC 83 +KR D+ V + + H N ++L LVFEF Sbjct: 81 DRSYMIKRFSEDEITGKRHRVKEVYNDIVLSARMSNHSNFLQLLGCCLEFPFPVLVFEFA 140 Query: 84 DQDLKK-----YFDSCNGDLDPEIVKSFLFQLLKGLGFCHS---RNVLHRDLKPQNLLIN 135 + + L + ++ + + H+ + ++HRD+KP ++ ++ Sbjct: 141 EHGAMNQRGGVIVNGEESLLPWSVRLKIGKEIANAVTYLHTAFPKIIIHRDVKPMHVFLD 200 Query: 136 RNGELKLADFGLARAFGIPVRCYSAE--VVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFA 193 +N KL+D + + AE + T Y P + + D++S G Sbjct: 201 KNWTAKLSDLSFSISLPEGKSRIEAEWVLGTFGYIDP-LYHKTCFVTEYTDVYSFGICLL 259 Query: 194 ELANAGRPLFPGNDVDDQ 211 + + +D D Q Sbjct: 260 VIITGKPAIMTISDGDLQ 277 >4IX6-A nrPDB Length = 350 Score = 96.8 bits (240), Expect = 9e-21, Method: Composition-based stats. Identities = 59/325 (18%), Positives = 100/325 (30%), Gaps = 62/325 (19%) Query: 10 IGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN-IVRLHD 68 +G G +GTVF+ + + V LK + D ++ K R Sbjct: 28 LGSGNFGTVFRGVFKGD-QDVVLKNAKADVMAAEELLECEMDVNYHVHANAKGTCARFMG 86 Query: 69 VLH----SDKKLT--LVFE---FC-----DQDLKKYFDSCNGDL----------DPEIVK 104 + ++ + E + ++ L + + K Sbjct: 87 CIELGAKDGGEIYNGTLTEGLWLMWANEGENTVEALMRRGTAPLATAMACADATELGVTK 146 Query: 105 SFLFQLLKGLGFCHSRNVLHRDLKPQNLLINR--NGELKLADFG---LARAFGIPVRCYS 159 + +LL L H V+HRD+KP NL+ G LKL D G L + Y Sbjct: 147 KAMRELLGSLARLHECGVVHRDVKPANLIAAEKDGGVLKLIDLGAAALCLPLPETLNYYP 206 Query: 160 AEVVT-LWYR-PPDVLFGAKLYSTSI----------------DMWSAGCIFAELANAGRP 201 + Y ++ D WSAGC+ +LA G Sbjct: 207 GDGPADPRYAKADELYLLPPGSPRPTKDNAAKLWEAHKPDRFDSWSAGCVMLQLAVVGL- 265 Query: 202 LFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRD 261 + ++ ++ +G + ++ T + G D Sbjct: 266 --RTDAGLERFLADYKAVG----------YDVNAFRGEKSGEYGTMDFAALDANGGAGWD 313 Query: 262 LLQNLLKCNPVQRISAEEALQHPYF 286 L Q L++ R S E AL H +F Sbjct: 314 LCQRLMEAERDARASCEAALSHAFF 338 >5UV4-A nrPDB Length = 311 Score = 96.1 bits (238), Expect = 1e-20, Method: Composition-based stats. Identities = 44/203 (21%), Positives = 80/203 (39%), Gaps = 14/203 (6%) Query: 8 EKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLH 67 E IG +GT +KA + ++ +K ++ REI L ++H N+V L Sbjct: 31 EIIGRSCHGTSYKAT-LDNGYMLTVKWLKEGFAKSK--KEFSREIKKLGSVRHPNLVPLR 87 Query: 68 DVLHSDKKL--TLVFEFCDQD-----LKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 K+ ++ ++ D L ++ + L + + + L + H+ Sbjct: 88 GYYWGPKEHERIMISDYADATSLSTYLSEFDERNLPPLSAGQRLNIAIDIARCLDYLHNE 147 Query: 121 NVL-HRDLKPQNLLI-NRNGELKLADFGLARAFG-IPVRCYSAEVVTLWYRPPDVLFGAK 177 V+ H ++K N+LI N + D+ L R I + L Y PP+ +K Sbjct: 148 RVIPHGNIKSSNVLIQNSTPSALVTDYSLHRLMTPIGMAEQVLNAGALGYSPPEFSSTSK 207 Query: 178 LY-STSIDMWSAGCIFAELANAG 199 S D+++ G I EL Sbjct: 208 PCPSLKSDVYAFGVILLELLTGK 230 >6EQI-C nrPDB Length = 433 Score = 93.0 bits (230), Expect = 1e-19, Method: Composition-based stats. Identities = 65/349 (18%), Positives = 120/349 (34%), Gaps = 102/349 (29%) Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRETH-----EIVALKRV---RLDDDDEGVPSSALRE- 51 + + + E I +G V+ AK + +A+K + ++ + + + RE Sbjct: 14 LDELDLGEPIAKGCNAVVYSAKLKNVQSNKLAHQLAVKMMFNYDVESNSTAILKAMYRET 73 Query: 52 --------------ICLLKELK-----HKNIVRLHDVLHSDKK----------------- 75 I + + K H NIVR++ V Sbjct: 74 VPAMSYFFNQNLFNIENISDFKIRLPPHPNIVRMYSVFADRIPDLQCNKQLYPEALPPRI 133 Query: 76 ----------LTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHR 125 L LV + D LK+Y ++ L QLL+ + + N+ HR Sbjct: 134 NPEGSGRNMSLFLVMKRYDCTLKEYLRDKTPNM--RSSILLLSQLLEAVAHMNIHNISHR 191 Query: 126 DLKPQNLLINRNG-----ELKLADFGLA---RAFGIPVRCYS---AEVVTLWYRPPDVLF 174 DLK N+L++ + + + DFG + G+ + S + P++ Sbjct: 192 DLKSDNILVDLSEGDAYPTIVITDFGCCLCDKQNGLVIPYRSEDQDKGGNRALMAPEIAN 251 Query: 175 GAKL-YS----TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPS 229 +S D+W+ G I E+ N P + K + L + EE P Sbjct: 252 AKPGTFSWLNYKKSDLWAVGAIAYEIFNIDNPFYD--------KTMKLLSKSYKEEDLP- 302 Query: 230 MTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAE 278 +LPD P+ + R+L+ N+L + +R+ + Sbjct: 303 --ELPDTIPFII------------------RNLVSNMLSRSTNKRLDCD 331 >5UU1-A nrPDB Length = 324 Score = 83.0 bits (204), Expect = 1e-16, Method: Composition-based stats. Identities = 43/229 (18%), Positives = 74/229 (32%), Gaps = 27/229 (11%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEG------------VPSSAL 49 ++ +KIG G +G ++ A E A V+++ + G + Sbjct: 16 NQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDCI 75 Query: 50 REICLLKELKHKNIVRLHDV----LHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKS 105 ++ K+L + I + +V E DL+K NG V Sbjct: 76 KKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQK-ISGQNGTFKKSTVLQ 134 Query: 106 FLFQLLKGLGFCHSRNVLHRDLKPQNLLIN--RNGELKLADFGLA-------RAFGIPVR 156 ++L L + H +H D+K NLL+ ++ LAD+GL+ Sbjct: 135 LGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNGNHKQYQEN 194 Query: 157 CYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPG 205 T+ + D G L S D+ G P Sbjct: 195 PRKGHNGTIEFTSLDAHKGVAL-SRRSDVEILGYCMLRWLCGKLPWEQN 242 >5CLR-A nrPDB Length = 451 Score = 82.6 bits (203), Expect = 2e-16, Method: Composition-based stats. Identities = 37/187 (19%), Positives = 74/187 (39%), Gaps = 19/187 (10%) Query: 19 FKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKK--L 76 FK + + LK V++D + + E L +L RL +++ Sbjct: 96 FKVYALDDGKTYFLKSVKIDAES---LTEFTNEKDTLSKLG-----RLVGTFFNEQTQVH 147 Query: 77 TLVFEFCDQ-DLKKYFDSCNGDLDPEI---VKSFLFQLLKGLGFCHSRNVLHRDLKPQNL 132 ++ F DL +Y ++ +++ + V + + + H ++HRDLKP N+ Sbjct: 148 YILTTFIKGIDLSRYKNALPLNVNLKHFWEVLGIMISVCHQVKQFHELGLIHRDLKPGNI 207 Query: 133 LINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL--YSTSIDMWSAGC 190 +++ + + L DFG + A T Y P++ +S D+++ Sbjct: 208 MLDADMQCHLVDFGSS---SSDKEPKPASWGTASYLAPELNAQEDFIAFSQVSDLFALAY 264 Query: 191 IFAELAN 197 EL N Sbjct: 265 SLDELFN 271 >4O1O-A nrPDB Length = 717 Score = 81.4 bits (200), Expect = 4e-16, Method: Composition-based stats. Identities = 56/291 (19%), Positives = 95/291 (32%), Gaps = 78/291 (26%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 ++Y+ + G ++ + + VA+KR EG CL + Sbjct: 350 EEYKIADT----AEGGIYLGLYED--QEVAVKRF-----SEGSTRGQQEVSCLQSSRAND 398 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDP----EIVKSFLFQLLKGLGFC 117 N+V + L + C+ L+++ + GD P E ++ L L K +G Sbjct: 399 NVVTFYGSESDGSCLHVCLALCEYTLQEHLANHRGDAVPNEEDESARNILSSLFKAIGEL 458 Query: 118 HSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAK 177 H H+DL+PQN+LI+ LADF + + + Sbjct: 459 HRSGYSHQDLQPQNILIDSKNGTFLADFDKSIKWAEDPQKIKR----------------- 501 Query: 178 LYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYK 237 D+ + G + + G F + I G+P EE Sbjct: 502 ------DLEALGLLVLYVVKKGDISFETLKNQSFEEVIQ---GSPDEET----------- 541 Query: 238 PYPMYPATTSLVNVVPKLNATGRDLLQNLLKC--NPVQRISAEEALQHPYF 286 RDL+ +L N R+S+ L HP+F Sbjct: 542 ----------------------RDLIHHLFHPGDNVEDRLSS--LLAHPFF 568 >2RSV-A nrPDB Length = 403 Score = 80.7 bits (198), Expect = 8e-16, Method: Composition-based stats. Identities = 48/292 (16%), Positives = 98/292 (33%), Gaps = 46/292 (15%) Query: 2 QKYEKLEKIGEGTYGTVFKA-----KNRETHEIVALKRVRLDD----------DDEGVPS 46 ++++ IG+G +G ++ A ++ + +K D+ P Sbjct: 42 KEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPE 101 Query: 47 SALREICLLKELKHKNIVRLHDVLHSDK----KLTLVFEFCDQDLKKYFDSCNGDLDPEI 102 + I ++LK+ + + DK ++ + DL+K +++ + Sbjct: 102 QIQKWIRT-RKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKT 160 Query: 103 VKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLIN--RNGELKLADFGLA-----RAFGIPV 155 V ++L L + H +H D+K NLL+N ++ L D+GLA Sbjct: 161 VLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEY 220 Query: 156 RCYSAEV--VTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPL--------FPG 205 + T+ + D G S D+ G + P + Sbjct: 221 KEDPKRCHDGTIEFTSIDAHNGVAP-SRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVR 279 Query: 206 NDVDDQLKRIFRLLGTPTEE--------QWPSMTKLPDYKPYPMYPATTSLV 249 + + I L+ E ++ KL DY P+Y ++ Sbjct: 280 DSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDIL 331 >2LAV-A nrPDB Length = 361 Score = 79.1 bits (194), Expect = 2e-15, Method: Composition-based stats. Identities = 39/229 (17%), Positives = 80/229 (34%), Gaps = 30/229 (13%) Query: 2 QKYEKLEKIGEGTYGTVFKA-----KNRETHEIVALKRVRLDD----------DDEGVPS 46 ++++ IG+G +G ++ A ++ + +K D+ P Sbjct: 35 KEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPE 94 Query: 47 SALREICLLKELKHKNIVRLHDVLHSDK----KLTLVFEFCDQDLKKYFDSCNGDLDPEI 102 + I ++LK+ + + DK ++ + DL+K +++ + Sbjct: 95 QIQKWIRT-RKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKT 153 Query: 103 VKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLIN--RNGELKLADFGLA-----RAFGIPV 155 V ++L L + H +H D+K NLL+N ++ L D+GLA Sbjct: 154 VLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEY 213 Query: 156 RCYSAEV--VTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPL 202 + T+ + D G S D+ G + P Sbjct: 214 KEDPKRCHDGTIEFTSIDAHNGVAP-SRRGDLEILGYCMIQWLTGHLPW 261 >4OAU-C nrPDB Length = 699 Score = 75.3 bits (184), Expect = 3e-14, Method: Composition-based stats. Identities = 35/149 (23%), Positives = 63/149 (42%), Gaps = 16/149 (10%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 +KY+ + + G ++ + + VA+K EG P + CL ++ Sbjct: 347 EKYKIADT----SEGGIYLGFYEK--QEVAVKTFC-----EGSPRAQREVSCLQSSRENS 395 Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGD----LDPEIVKSFLFQLLKGLGFC 117 ++V + L + C+Q L+ D G+ + E ++ L + K + Sbjct: 396 HLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQEL 455 Query: 118 H-SRNVLHRDLKPQNLLINRNGELKLADF 145 H S H+DL+PQN+LI+ LADF Sbjct: 456 HLSCGYTHQDLQPQNILIDSKKAAHLADF 484 >6G4J-A nrPDB Length = 315 Score = 70.6 bits (172), Expect = 8e-13, Method: Composition-based stats. Identities = 40/201 (19%), Positives = 71/201 (35%), Gaps = 28/201 (13%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63 Y +++G+G G V+ A+ + H VALK S E+ +LK Sbjct: 28 YTLRKQLGKGANGIVYLAETSDGH--VALKV-------SDDSLSITSEVNVLKSFSKAQS 78 Query: 64 VRLHDVLHSDKKLTL----------VFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKG 113 V + + E+ L + S G E + + QLL Sbjct: 79 VTMGPSFFDTDDAYIPSANTKVSFYAMEYIKGPLLLKYVSDKGA---EWIPVLMIQLLSS 135 Query: 114 LGFCHSRNVLHRDLKPQNLLIN-RNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDV 172 L H + + DLKP NL++ ++ D G G ++ Y+ ++ Sbjct: 136 LSVLHQQGWIFGDLKPDNLIVTGPPARIRCIDVGGTTKEGRAIKEYTEFYDRGYW----- 190 Query: 173 LFGAKLYSTSIDMWSAGCIFA 193 +G + S D+++ I Sbjct: 191 GYGTRKAEPSYDLFAVAMIMI 211 >4CI6-B nrPDB Length = 643 Score = 68.3 bits (166), Expect = 3e-12, Method: Composition-based stats. Identities = 48/280 (17%), Positives = 92/280 (32%), Gaps = 39/280 (13%) Query: 24 RETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHD---VLHSDKKLT-LV 79 ++ +VA K R + + KH N+ +H V + ++ L+ Sbjct: 66 KDKQRLVA-KIERSIAEGHLFAELEAYKHIYKTAGKHPNLANVHGMAVVPYGNRYYYALL 124 Query: 80 FEFCDQ-----DLKKYFD-----SCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKP 129 + D L+ D N + +K +LL ++H D+KP Sbjct: 125 MDEVDGWRCSDTLRSLADSWKQGKINSEAYWGTIKFIAHRLLDVTNHLAKAGIVHNDIKP 184 Query: 130 QNLLINR-NGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSA 188 N++ +R +GE + D GL G + + T ++ P++ G S D+ Sbjct: 185 GNVVFDRASGEPVVIDLGLHSRSGEQPKGF-----TESFKAPELGVGNLGASEKSDV--- 236 Query: 189 GCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSL 248 L G + ++ I P + ++ YP Sbjct: 237 -------FLVVSTLLHGIEGFEKDPEI-----KPNQGLRFITSEPAHVMDENGYPIHRPG 284 Query: 249 VNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288 + V + ++L + R + EA H + SD Sbjct: 285 IAGVETAYTR---FITDILGVSADSRPDSNEARLHEFLSD 321 >5DMZ-A nrPDB Length = 365 Score = 66.8 bits (162), Expect = 1e-11, Method: Composition-based stats. Identities = 36/214 (16%), Positives = 76/214 (35%), Gaps = 26/214 (12%) Query: 10 IGEGTYGTVFKAK-----NRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIV 64 +GEG + V++A + + + LK + + E + L E L ++H + Sbjct: 73 LGEGAFAQVYEATQGDLNDAKNKQKFVLKVQKPANPWEFYIGTQLME-RLKPSMQHMF-M 130 Query: 65 RLHDVLHSDKKLTLVFEFCDQDLKK-----YFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 119 + + LV E Y ++ + +V SF ++L + H Sbjct: 131 KFYSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEKVMPQGLVISFAMRMLYMIEQVHD 190 Query: 120 RNVLHRDLKPQNLLINRNGE-----------LKLADFGLARAFGI--PVRCYSAEVVTLW 166 ++H D+KP N ++ L L D G + + ++A+ T Sbjct: 191 CEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMKLFPKGTIFTAKCETSG 250 Query: 167 YRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGR 200 ++ ++L K ++ ID + + Sbjct: 251 FQCVEMLSN-KPWNYQIDYFGVAATVYCMLFGTY 283 >6EAS-A nrPDB Length = 308 Score = 65.6 bits (159), Expect = 2e-11, Method: Composition-based stats. Identities = 37/258 (14%), Positives = 79/258 (30%), Gaps = 24/258 (9%) Query: 19 FKAKNRETHEIVALK---RVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKK 75 +K + +A+ D + S ++I L ++ HKN + L + Sbjct: 57 YKGT-LSSGVEIAVASSLVTSAKDWSKENESQYRKKITNLSKVSHKNFMNLLGYCEEEHP 115 Query: 76 L--TLVFEFC-DQDLKKYFDSCNGD-LDPEIVKSFLFQLLKGLGFCHSRNV--LHRDLKP 129 +VFE+ + L ++ + LD + L H R+ Sbjct: 116 FTRVMVFEYAPNGTLFEHLHVREAEKLDWMARLRISMGIAYCLEHMHQLQTPAALRNFDS 175 Query: 130 QNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAG 189 + + + K++D + E+ PD+ + Y G Sbjct: 176 TTVYLTDDFAAKVSDLEFWNDAKGHNSTTNNELA----FSPDMEDIVRKY---------G 222 Query: 190 CIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQW-PSMTKLPDYKPYPMYPATTSL 248 + E+ P + + + G EE PS+ P+ + S Sbjct: 223 MVLLEILTGRVPSSEDDGPLENWVSRYFEGGMRLEELIDPSIGFFPEDTARALCEVVRSC 282 Query: 249 VNVVPKLNATGRDLLQNL 266 ++ PK +++ + Sbjct: 283 IDRDPKKRPQMKEVAARM 300 >2JII-A nrPDB Length = 352 Score = 58.7 bits (141), Expect = 3e-09, Method: Composition-based stats. Identities = 32/170 (18%), Positives = 60/170 (35%), Gaps = 12/170 (7%) Query: 70 LHSDKKLTLVFEFCDQDLKKYFD-SCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLK 128 +H DK LV + L+ D S L V +LL L F H +H ++ Sbjct: 127 VHQDKYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVT 186 Query: 129 PQNLLIN--RNGELKLADFGLARAFGIPVRCYSAEVVTL-------WYRPPDVLFGAKLY 179 +N+ ++ ++ LA +G A + + + + + D+ G Sbjct: 187 AENIFVDPEDQSQVTLAGYGFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMDLHKGCGP- 245 Query: 180 STSIDMWSAGCIFAELANAGRPLFPG-NDVDDQLKRIFRLLGTPTEEQWP 228 S D+ S G + P + +D +K+ + + P P Sbjct: 246 SRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFVGP 295 >6EWX-A nrPDB Length = 484 Score = 57.5 bits (138), Expect = 7e-09, Method: Composition-based stats. Identities = 37/232 (15%), Positives = 68/232 (29%), Gaps = 72/232 (31%) Query: 92 DSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNG------------- 138 ++ V L QL GL ++HRDL +NLL+ Sbjct: 201 HRAEPEVYERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLVHCNPQSSPGPSANPSV 260 Query: 139 ----------------------------ELKLADFGLARAFGIPVRCYSAEVVTLWYRPP 170 L +++F A+ + P Sbjct: 261 PTTTSRCPSAAPAATTACQGGPGEKHLPRLIISNFLKAKQKPGGTTNLQQKKSQAR-LAP 319 Query: 171 DVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSM 230 +++ ++ D + G + EL + P +V QL+ Sbjct: 320 EIVSASQY--RKFDEFQTGILIYELLHQPNPF----EVRAQLRE---------------- 357 Query: 231 TKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQ 282 DY+ + P T + + + L LL+ +P++RI EA + Sbjct: 358 ---RDYRREDLPPLPT-----LSLYSPGLQQLAHLLLEADPIKRIRIGEAKR 401 >4AZV-A nrPDB Length = 569 Score = 56.8 bits (136), Expect = 1e-08, Method: Composition-based stats. Identities = 21/113 (18%), Positives = 42/113 (37%), Gaps = 4/113 (3%) Query: 35 VRLDDDDEGVPSSALREICLLKEL-KHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDS 93 + ++ + EI L + + + + + LV E L + Sbjct: 275 ILTAEESQRNKYELHNEIKFLTQPPAGFDAPAVLAHGENAQSGWLVMEKLPGRLLSDMLA 334 Query: 94 CNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFG 146 ++D E L LL+ L + H D++P N++++ +L DFG Sbjct: 335 AGEEIDRE---KILGSLLRSLAALEKQGFWHDDVRPWNVMVDARQHARLIDFG 384 >4AZW-A nrPDB Length = 471 Score = 56.0 bits (134), Expect = 2e-08, Method: Composition-based stats. Identities = 21/113 (18%), Positives = 42/113 (37%), Gaps = 4/113 (3%) Query: 35 VRLDDDDEGVPSSALREICLLKEL-KHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDS 93 + ++ + EI L + + + + + LV E L + Sbjct: 275 ILTAEESQRNKHELHNEIKFLTQPPAGFDAPAVLAHGENAQSGWLVMEKLPGRLLSDMLA 334 Query: 94 CNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFG 146 ++D E L LL+ L + H D++P N++++ +L DFG Sbjct: 335 AGEEIDRE---KILGSLLRSLAALEKKGFWHDDVRPWNVMVDARQHARLIDFG 384 >6M7Z-A nrPDB Length = 319 Score = 55.6 bits (133), Expect = 2e-08, Method: Composition-based stats. Identities = 30/219 (13%), Positives = 63/219 (28%), Gaps = 51/219 (23%) Query: 79 VFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNG 138 +F + L V+ ++ L H+ +LHR ++ + + +G Sbjct: 124 IFHPLSKGLVGDMLETGR--SHPDVQVLAANMVAALKSLHNLGLLHRSIELNSFSVLPDG 181 Query: 139 ELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDV--------LFGAKLYSTSIDMWSAGC 190 + L A G R + P++ ++ D++S G Sbjct: 182 TVVLGGLDTAAPIGTETRLWVGFFGQE--TAPEIDRNFLADLALTQGRHTVKSDVYSLGV 239 Query: 191 IFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVN 250 + + +LLG P + Sbjct: 240 --------------------AFRNLVQLLGNGNLG------------PEDRGAVRQDHLE 267 Query: 251 VVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDF 289 ++ KL+ Q +++ P R + EE ++ P F Sbjct: 268 LLDKLS-------QKMIEEEPGNRPTIEEIMKDPLFEGL 299 >5GZ9-A nrPDB Length = 305 Score = 55.6 bits (133), Expect = 3e-08, Method: Composition-based stats. Identities = 33/209 (15%), Positives = 66/209 (31%), Gaps = 38/209 (18%) Query: 7 LEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRL 66 L+++GEG VF ++ +E VAL R+ + E L + +LK L+ +++V L Sbjct: 39 LKRVGEGAVKRVFLSEWKE--HKVALSRLTRLEMKE----DFLHGLQMLKSLQSEHVVTL 92 Query: 67 HDVLHSDKKLTLVFEFCD-QDLKKY-----FDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 D ++ E+ L + + + + + H Sbjct: 93 VGYCEEDGT--ILTEYHPLGSLSNLEETLQLSKYQDVNTWQHRLQLAMEYVSIINYLHHS 150 Query: 121 NVLHRDLKPQN--------LLINRNGELKLADFGLARAFGIPVRCYSAEVVTLW----YR 168 + R + N L+ N + D A + + Sbjct: 151 PLGTRVMCDSNDLPKTLSQYLLTSNFSIVANDLD-ALPLVDHDSGVLIKCGHRELHGDFV 209 Query: 169 PPDVLFGA-----------KLYSTSIDMW 186 P+ L+ Y+ +D+W Sbjct: 210 APEQLWPYGEDTPFQDDLMPSYNEKVDIW 238 >5GZA-A nrPDB Length = 290 Score = 55.2 bits (132), Expect = 3e-08, Method: Composition-based stats. Identities = 34/217 (15%), Positives = 60/217 (27%), Gaps = 51/217 (23%) Query: 5 EKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIV 64 +++ IG+G V+ ++ + VAL + D L + +L+ L+ ++V Sbjct: 28 RRVKLIGQGAVKKVYLSEW--QGQKVALSVLSSDQ----YADDFLHGLSMLRALQSSHVV 81 Query: 65 RLHDVLHSDKKLTLVFEFCDQDLKKYFD------SCNGDLDPEIVKSFLFQLLKGLGFCH 118 L V D V E+ D + L + H Sbjct: 82 TLVGVCEED--AVFVTEYHPLGSVLTLDTTLAQERYRWRNSWHTRLQLAIDYVAFLAYLH 139 Query: 119 SR--NV--------LHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVV----- 163 S + LH+ L L+ + L LA + Sbjct: 140 SSPAGIRVMCDSNDLHKTL--SQFLLASDMRL------LANDLDALPEVEKGGLGVKCGH 191 Query: 164 ---TLWYRPPDVL-----------FGAKLYSTSIDMW 186 T + P+ L Y D+W Sbjct: 192 HELTGDFVAPEQLWPYGEDFSFSDEAMPGYDEKTDIW 228 >3ENH-A nrPDB Length = 540 Score = 54.8 bits (131), Expect = 4e-08, Method: Composition-based stats. Identities = 30/160 (18%), Positives = 59/160 (36%), Gaps = 18/160 (11%) Query: 10 IGEGTYGTVFKAKNRETHEIVALK-RVRLDDDDEGVPSSAL-----REICLLKELKHKNI 63 IG+G + ++ V +K RV+ DE + + RE L +K I Sbjct: 344 IGKGAEADIK--RDSYLDFDVIIKERVKKGYRDERLDENIRKSRTAREARYLALVKDFGI 401 Query: 64 VRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVL 123 + ++ + + L K N +++ + +G H +V+ Sbjct: 402 PAPYIFDVDLDNKRIMMSYINGKLAKDVIEDN--------LDIAYKIGEIVGKLHKNDVI 453 Query: 124 HRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVV 163 H DL N + +++ L + DFGL + + +V Sbjct: 454 HNDLTTSNFIFDKD--LYIIDFGLGKISNLDEDKAVDLIV 491 >4CYJ-A nrPDB Length = 438 Score = 53.7 bits (128), Expect = 9e-08, Method: Composition-based stats. Identities = 27/146 (18%), Positives = 60/146 (41%), Gaps = 19/146 (13%) Query: 15 YG---TVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLH 71 +G V+KA+N AL+R+ + + L + K++K+ +IV +H+V Sbjct: 65 FGYPSWVYKAQNSRNGRHYALRRL--EGYRLTNEKAILNVMKDWKKIKNASIVTIHEVFT 122 Query: 72 SDKKL--TLVFEFCDQDLKKYFDSCN------------GDLDPEIVKSFLFQLLKGLGFC 117 + + +L+F + L K + + + ++ Q+ L Sbjct: 123 TREFGDSSLIFAYDFHPLSKTLQEHHFQPIHGNRYRPPPAVPENTIWGYICQIANALKTI 182 Query: 118 HSRNVLHRDLKPQNLLINRNGELKLA 143 HS + R L+P +++ ++L+ Sbjct: 183 HSNRLAARCLEPSKIILTDINRIRLS 208 >6BHC-A nrPDB Length = 438 Score = 51.0 bits (121), Expect = 5e-07, Method: Composition-based stats. Identities = 46/300 (15%), Positives = 81/300 (27%), Gaps = 88/300 (29%) Query: 30 VALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSD---------------- 73 A+K + + +L L H NI + ++ Sbjct: 86 YAVKICKSKAKESQQYYHSLAVRQSLA--VHFNIQQDCGHFLAEVPNRLLPWEDPSKKQR 143 Query: 74 KKLTLVF---------EFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLH 124 + ++ +F L ++ S DL V L QL GL +V H Sbjct: 144 SHVVVITREVPCLTVADFVRDSLAQHGKS--PDLYERQVCLLLLQLCSGLEHLKPYHVTH 201 Query: 125 RDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWY----------------- 167 DL+ +NLL+ G A+ FG ++ T Sbjct: 202 CDLRLENLLLVHYQPG-----GTAQGFGPAEPTPTSSYPTRLIVSNFSQAKQKSHLVDPE 256 Query: 168 -------RPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLG 220 P+++ + D + G + E+ + P Sbjct: 257 ILRDQSRLAPEIITATQY--KKCDEFQTGILIYEMLHLPNPF------------------ 296 Query: 221 TPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEA 280 + P+ K A + + + L LL NP +RI +A Sbjct: 297 ----------DENPELKEREYTRADLPRIPFRSPYSRGLQQLASCLLNPNPSERILISDA 346 >5VE6-A nrPDB Length = 492 Score = 49.5 bits (117), Expect = 2e-06, Method: Composition-based stats. Identities = 13/35 (37%), Positives = 17/35 (48%) Query: 100 PEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLI 134 V L QL GL ++HRDL +NLL+ Sbjct: 207 ERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLL 241 Score = 34.8 bits (79), Expect = 0.045, Method: Composition-based stats. Identities = 21/115 (18%), Positives = 40/115 (34%), Gaps = 30/115 (26%) Query: 168 RPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQW 227 P+++ ++ D + G + EL + P +V QL+ +E Sbjct: 325 LAPEIVSASQY--RKFDEFQTGILIYELLHQPNPF----EVRAQLRE-----RDYRQEDL 373 Query: 228 PSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQ 282 P + L Y + + L LL+ +P++RI EA + Sbjct: 374 PPLPALSLY-------------------SPGLQQLAHLLLEADPIKRIRIGEAKR 409 >6G38-A nrPDB Length = 357 Score = 48.3 bits (114), Expect = 3e-06, Method: Composition-based stats. Identities = 39/177 (22%), Positives = 56/177 (31%), Gaps = 49/177 (27%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLD------DDDEGVPSSALREICLL 55 +K ++ EKIGEG +G VF + H VA+K + ++ + L EI + Sbjct: 41 EKLQRCEKIGEGVFGEVF--QTIADHTPVAIKIIAIEGPDLVNGSHQKTFEEILPEIIIS 98 Query: 56 KE-----------------LKHKNIVR------LHDVLHS----------------DKKL 76 KE L + V+ L D +L Sbjct: 99 KELSLLSGEVCNRTEGFIGLNSVHCVQGSYPPLLLKAWDHYNSTKGSANDRPDFFKDDQL 158 Query: 77 TLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCH-SRNVLHRDLKPQNL 132 +V EF + KS L QL L S HRDL N+ Sbjct: 159 FIVLEFEFGGI-DLEQMRTKLSSLATAKSILHQLTASLAVAEASLRFEHRDLHWGNV 214 >3Q60-A nrPDB Length = 371 Score = 47.9 bits (113), Expect = 6e-06, Method: Composition-based stats. Identities = 54/327 (16%), Positives = 97/327 (29%), Gaps = 74/327 (22%) Query: 2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61 +K + +E + G VF ++ E E ALK + ++ L E Sbjct: 62 RKLKLVEPLRVGDRSVVFLVRDVERLEDFALKVFTMGAENSRSELERLHEATFAAA---- 117 Query: 62 NIVRLHD-------------------VLHSDKKL---------------TLVFEFCDQDL 87 RL + S L+ DL Sbjct: 118 ---RLLGESPEEARDRRRLLLPSDAVAVQSQPPFAQLSPGQDDYAVANYLLLMPAASVDL 174 Query: 88 ------KKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELK 141 + GD + QL++ S+ ++H P NL I +G L Sbjct: 175 ELLFSTLDFVYVFRGDEGILALHILTAQLIRLAANLQSKGLVHGHFTPDNLFIMPDGRLM 234 Query: 142 LADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAK-LYSTSIDMWSAGCIFAELANAGR 200 L D ++ + + R ++ V Y P + L + ++ +++ W G + Sbjct: 235 LGD--VSALWKVGTRGPASSVPVT-YAPREFLNASTATFTHALNAWQLGLSIYRVWCLFL 291 Query: 201 PLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATG- 259 P L+ + W +P P T SL Sbjct: 292 PF--------------GLVTPGIKGSWK--------RPSLRVPGTDSLAFGSCTPLPDFV 329 Query: 260 RDLLQNLLKCNPVQRISAEEALQHPYF 286 + L+ L + +R+ EA++ P F Sbjct: 330 KTLIGRFLNFDRRRRLLPLEAMETPEF 356 >4WWA-A nrPDB Length = 261 Score = 47.5 bits (112), Expect = 6e-06, Method: Composition-based stats. Identities = 33/150 (22%), Positives = 62/150 (41%), Gaps = 23/150 (15%) Query: 19 FKAKNRETHEIVALK-----RVRLDDDDEGVPS-SALREICLLKELK---HKNIVRLHDV 69 + + +++H+ +K R R D+ + L E LL +L + +L Sbjct: 38 YLPRAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIAC 97 Query: 70 LHSDKKLTLVFEFCDQDL---------KKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 + + L EF +DL K + + D ++V + L ++ + +G H Sbjct: 98 DPYNGFIWL--EFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWN 155 Query: 121 NVLHRDLKPQNLLINRNG---ELKLADFGL 147 + H DL N+++ R+G L DFGL Sbjct: 156 DYCHGDLTSSNIVLVRDGARWTPHLIDFGL 185 >2W1Z-A nrPDB Length = 368 Score = 47.1 bits (111), Expect = 9e-06, Method: Composition-based stats. Identities = 32/188 (17%), Positives = 56/188 (29%), Gaps = 9/188 (4%) Query: 85 QDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLAD 144 D+ S + L QL++ ++H D + +N+L+++ G + L Sbjct: 175 GDVLLSHSSTHKSLVHHARLQLTLQLIRLAASLQHYGLVHADFQVRNILLDQRGGVFLTG 234 Query: 145 FG-LARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLY----STSIDMWSAGCIFAELANAG 199 F L R V +L + + + D W+ G + A Sbjct: 235 FEHLVRDGASAVSPIGRGFAPPETTAERMLPYRQHHPTLMTFPFDTWTLGLAIYWIWCAD 294 Query: 200 RPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATG 259 P N D +L I + P L + Y L + Sbjct: 295 LP----NTEDAELGGIEWIYRRCKNIPQPVRALLEGFLRYSKEDRLLPLQAMETSEYEQL 350 Query: 260 RDLLQNLL 267 R L +L Sbjct: 351 RTELSAVL 358 >4BWP-A nrPDB Length = 448 Score = 46.8 bits (110), Expect = 1e-05, Method: Composition-based stats. Identities = 26/139 (18%), Positives = 46/139 (33%), Gaps = 38/139 (27%) Query: 19 FKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHS----DK 74 ++A + T +R + + + + K+L+H N+V+L +V + D Sbjct: 67 YRATHNTTGYKY---CLRRIHGFRLQSTKCMTLVEMWKKLQHTNVVQLREVFTTKAFGDN 123 Query: 75 KLTLVFEFCDQD---LKKYF----------------------------DSCNGDLDPEIV 103 L LV+++ L KYF S L + Sbjct: 124 SLVLVYDYHPGSQTLLAKYFTPAPETNGYTDPFQGEARPFSHKSNMQRTSNGPLLPEATI 183 Query: 104 KSFLFQLLKGLGFCHSRNV 122 S + QL GL H + Sbjct: 184 WSIIMQLTAGLKAIHHAGL 202 >3BYV-A nrPDB Length = 377 Score = 46.8 bits (110), Expect = 1e-05, Method: Composition-based stats. Identities = 34/226 (15%), Positives = 78/226 (34%), Gaps = 48/226 (21%) Query: 20 KAKNRETHEIV--------------ALKRVRLD---------DDDEGVPSSALREICLLK 56 +A ++ET E A+K+++ + ++ LR I Sbjct: 91 EATDQETGESFEVHVPYFTERPPSNAIKQMKEEVLRLRLLRGIKNQKQAKVHLRFIFPFD 150 Query: 57 ELKHKNIVRLHDVLHSDKKLTLVFEF-----CDQDLKKY------FDSCNGDLDPEIVKS 105 +K ++ V ++ + ++ F +L+ + S + L Sbjct: 151 LVKDPQKKKMIRVRLDERDMWVLSRFFLYPRMQSNLQTFGEVLLSHSSTHKSLVHHARLQ 210 Query: 106 FLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTL 165 Q+++ L H ++H L+P ++++++ G + L F + V+ Sbjct: 211 LTLQVIRLLASLHHYGLVHTYLRPVDIVLDQRGGVFLTGF----EHLVRDGARVVSSVSR 266 Query: 166 WYRPPDV----------LFGAKLYSTSIDMWSAGCIFAELANAGRP 201 + PP++ L + S D W+ G + + A P Sbjct: 267 GFEPPELEARRATISYHRDRRTLMTFSFDAWALGLVIYWIWCADLP 312 >3DZO-A nrPDB Length = 413 Score = 45.2 bits (106), Expect = 3e-05, Method: Composition-based stats. Identities = 33/221 (14%), Positives = 75/221 (33%), Gaps = 39/221 (17%) Query: 20 KAKNRETHEIV--------------ALKRVRLD---------DDDEGVPSSALREICLLK 56 +A ++ET E A+K+++ + ++ LR I Sbjct: 96 EATDQETGESFEVHVPYFTERPPSNAIKQMKEEVLRLRLLRGIKNQKQAKVHLRFIFPFD 155 Query: 57 ELKHKNIVRLHDVLHSDKKLTLVFEF-----CDQDLKKY------FDSCNGDLDPEIVKS 105 +K ++ V ++ + ++ F +L+ + S + L Sbjct: 156 LVKDPQKKKMIRVRLDERDMWVLSRFFLYPRMQSNLQTFGEVLLSHSSTHKSLVHHARLQ 215 Query: 106 FLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFG-LARAFGIPVRCYSAEVVT 164 Q+++ L H ++H L+P ++++++ G + L F L R V Sbjct: 216 LTLQVIRLLASLHHYGLVHTYLRPVDIVLDQRGGVFLTGFEHLVRDGASAVSPIGRGFAP 275 Query: 165 LWYRPPDVLFGAKLY----STSIDMWSAGCIFAELANAGRP 201 +L + + + + D W+ G + A P Sbjct: 276 PETTAERMLPFGQHHPTLMTFAFDTWTLGLAIYWIWCADLP 316 >4CZY-B nrPDB Length = 429 Score = 42.1 bits (98), Expect = 3e-04, Method: Composition-based stats. Identities = 27/140 (19%), Positives = 56/140 (40%), Gaps = 18/140 (12%) Query: 19 FKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHS----DK 74 +KA+N + AL+R+ + + L K++ + NIV +H+ + D Sbjct: 61 YKAQNNKNGRHFALRRI--EGYRLTNEKAILNVTKEWKKIINANIVTVHEAFTTEFFGDS 118 Query: 75 KLTLVFEF--CDQDLKKYF---------DSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVL 123 L V++F + L + + ++ S++ Q+ L H+ + Sbjct: 119 SLIFVYDFHPLSETLYDHHFPPNNSHNRLRNTNKIPENLLWSYVCQIANALLAIHNAKLA 178 Query: 124 HRDLKPQNLLINRNGELKLA 143 R L+ + I N ++LA Sbjct: 179 ARCLELSKI-IWENNRIRLA 197 >1TQM-A nrPDB Length = 282 Score = 41.0 bits (95), Expect = 6e-04, Method: Composition-based stats. Identities = 33/165 (20%), Positives = 62/165 (37%), Gaps = 27/165 (16%) Query: 6 KLEKIGEGTYGTVFKAKNRETHEIVAL---------KRVRLDDD------DEGVPSSALR 50 + +GEG VF + + E V K+V+ D SA Sbjct: 94 IGKLMGEGKESAVFNCYSEKFGECVVKFHKVGHTSFKKVKEKRDYGDLHFSVLAIRSARN 153 Query: 51 EICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQL 110 E L++L+ + +++ + ++ E D K + E++ L ++ Sbjct: 154 EFRALQKLQGLAVPKVYAW----EGNAVLMELIDA---KELYRVRVENPDEVLDMILEEV 206 Query: 111 LKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPV 155 K F H R ++H DL N+L++ G + + DF + G Sbjct: 207 AK---FYH-RGIVHGDLSQYNVLVSEEG-IWIIDFPQSVEVGEEG 246 >6FAI-l nrPDB Length = 425 Score = 36.7 bits (84), Expect = 0.010, Method: Composition-based stats. Identities = 23/169 (13%), Positives = 52/169 (30%), Gaps = 36/169 (21%) Query: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVR---------------LDDDDEGVPSSA 48 Y IG G ++K ++ + V +K R L ++G Sbjct: 95 YSVGNTIGVGKESDIYKVSDKNGNPRV-MKIHRLGRTSFHSVRNNRDYLKKSNQGANWMH 153 Query: 49 L------REICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEI 102 L +E + L K ++ + + + + +V E + + Sbjct: 154 LSRLAANKEYQFMSMLYSKGF-KVPEPFDNSRHI-VVMELIEGYPMRRLRKHKN------ 205 Query: 103 VKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINR------NGELKLADF 145 + L+ + + ++H D N++I + + DF Sbjct: 206 IPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDF 254 >5YK0-A nrPDB Length = 452 Score = 35.6 bits (81), Expect = 0.027, Method: Composition-based stats. Identities = 26/169 (15%), Positives = 49/169 (28%), Gaps = 41/169 (24%) Query: 16 GTVFKAKNRETHEIVALKR-------------------------VRLDDDDEGVPSSALR 50 G V KA VA+K + D +GV + Sbjct: 146 GQVHKAIW-SDGREVAVKIQYPGADEALRADLKTMQRMVGVLKQLSPGADVQGVVDELVE 204 Query: 51 --EICLLKELKHKNIVRLHDVLHSDKKL-----------TLVFEFCDQDLKKYFDSCNGD 97 E+ L L+ N H + ++ E+ + Sbjct: 205 RTEMELDYRLEAANQRAFAKAYHDHPRFQVPHVVASAPKVVIQEWIEGVPMAEIIRHGTT 264 Query: 98 LDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFG 146 +++ + L +L ++H D P N ++ +G + + DFG Sbjct: 265 EQRDLIGTLLAELT--FDAPRRLGLMHGDAHPGNFMLLPDGRMGIIDFG 311 >6G18-v nrPDB Length = 552 Score = 32.9 bits (74), Expect = 0.18, Method: Composition-based stats. Identities = 9/74 (12%), Positives = 28/74 (37%), Gaps = 6/74 (8%) Query: 72 SDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQN 131 + +V E + + C + + + ++ + + ++H D N Sbjct: 180 DYNRHAVVMELING-----YPLCQIHHVEDPASVY-DEAMELIVKLANHGLIHGDFNEFN 233 Query: 132 LLINRNGELKLADF 145 L+++ + + + DF Sbjct: 234 LILDESDHITMIDF 247 >4BVU-A nrPDB Length = 211 Score = 32.5 bits (73), Expect = 0.20, Method: Composition-based stats. Identities = 26/146 (17%), Positives = 51/146 (34%), Gaps = 22/146 (15%) Query: 6 KLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVR 65 + IG+G+ +F+ N + K + + + A +E L Sbjct: 44 LGKLIGQGSTAEIFEDVNDSSALYK--KYDLIGNQYNEILEMAWQESELFNA-------- 93 Query: 66 LHD-----VLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120 + V+ + L D+ + P+ ++S QL+ L Sbjct: 94 FYGDEASVVIQYGGDVYLRMLRVPGTPLSDIDTADI---PDNIESLYLQLICKLNEL--- 147 Query: 121 NVLHRDLKPQNLLINRNGE-LKLADF 145 +++H DL N+L ++ E L DF Sbjct: 148 SIIHYDLNTGNMLYDKESESLFPIDF 173 >6FDN-A nrPDB Length = 320 Score = 31.7 bits (71), Expect = 0.41, Method: Composition-based stats. Identities = 9/74 (12%), Positives = 28/74 (37%), Gaps = 6/74 (8%) Query: 72 SDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQN 131 + +V E + + C + + + ++ + + ++H D N Sbjct: 180 DYNRHAVVMELING-----YPLCQIHHVEDPASVY-DEAMELIVKLANHGLIHGDFNEFN 233 Query: 132 LLINRNGELKLADF 145 L+++ + + + DF Sbjct: 234 LILDESDHITMIDF 247 >6G5I-z nrPDB Length = 568 Score = 30.6 bits (68), Expect = 0.74, Method: Composition-based stats. Identities = 14/69 (20%), Positives = 25/69 (36%), Gaps = 2/69 (2%) Query: 77 TLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFC-HSRNVLHRDLKPQNLLIN 135 LV F +D N L + Q+++ + ++H DL N+L Sbjct: 274 VLVMSFIGKDDMPAPLLKNVQLSESKARELYLQVIQYMRRMYQDARLVHADLSEFNMLY- 332 Query: 136 RNGELKLAD 144 G + + D Sbjct: 333 HGGGVYIID 341 >4OTP-A nrPDB Length = 352 Score = 30.6 bits (68), Expect = 0.95, Method: Composition-based stats. Identities = 14/69 (20%), Positives = 25/69 (36%), Gaps = 2/69 (2%) Query: 77 TLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFC-HSRNVLHRDLKPQNLLIN 135 LV F +D N L + Q+++ + ++H DL N+L Sbjct: 132 VLVMSFIGKDDMPAPLLKNVQLSESKARELYLQVIQYMRRMYQDARLVHADLSEFNMLY- 190 Query: 136 RNGELKLAD 144 G + + D Sbjct: 191 HGGGVYIID 199 >6EF6-A nrPDB Length = 354 Score = 29.8 bits (66), Expect = 1.5, Method: Composition-based stats. Identities = 8/28 (28%), Positives = 16/28 (57%), Gaps = 3/28 (10%) Query: 121 NVLHRDLKPQNLLINRN---GELKLADF 145 ++H DL+ NLL++ + + + DF Sbjct: 226 GLIHADLRLANLLVDSSTPQRTITVIDF 253 >3CNW-A nrPDB Length = 148 Score = 29.4 bits (65), Expect = 1.6, Method: Composition-based stats. Identities = 15/72 (20%), Positives = 26/72 (36%), Gaps = 2/72 (2%) Query: 216 FRLLGTPTE--EQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQ 273 + G+P + + LPD+ PY T V N G +++ L N + Sbjct: 10 MEIFGSPEQVWQLIGGFNSLPDWLPYIPSSKLTEGGRVRHLANPDGDTIIERLEVFNDKE 69 Query: 274 RISAEEALQHPY 285 R + P+ Sbjct: 70 RYYTYSIMNAPF 81 >5LJ3-H nrPDB Length = 591 Score = 29.4 bits (65), Expect = 2.1, Method: Composition-based stats. Identities = 15/40 (37%), Positives = 21/40 (52%), Gaps = 1/40 (2%) Query: 124 HRDLKPQNLLINRNGELK-LADFGLARAFGIPVRCYSAEV 162 HRDL N+LI R+ K + DF L + G + SA + Sbjct: 41 HRDLFQVNILIGRDIICKNVVDFTLNKQNGRLIPALSALI 80 >2D51-A nrPDB Length = 406 Score = 29.0 bits (64), Expect = 2.2, Method: Composition-based stats. Identities = 15/72 (20%), Positives = 30/72 (41%), Gaps = 2/72 (2%) Query: 189 GCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSL 248 G +F + G P+ N+V+ L +F+ +G E W S+ +P + + Sbjct: 275 GMMFY--LSKGSPMTISNNVEACLIDVFKSVGITPPEDWNSLFWIPHPGGRAILDQVEAK 332 Query: 249 VNVVPKLNATGR 260 + + P+ R Sbjct: 333 LKLRPEKFRAAR 344 >5JY7-I nrPDB Length = 441 Score = 28.3 bits (62), Expect = 3.7, Method: Composition-based stats. Identities = 14/77 (18%), Positives = 27/77 (35%), Gaps = 10/77 (12%) Query: 18 VFKAKNRETHEIV---ALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDK 74 VF A+ T + A+ ++ P L +L + ++ RL ++ Sbjct: 126 VFGAEQSNTSVVFGEDAIFKLFRRITPGVHPDIELN--RVLARAGNPHVARLLGSFETEW 183 Query: 75 K-----LTLVFEFCDQD 86 + L +V EF Sbjct: 184 EGEPYALGMVTEFAANS 200 >5IOL-A nrPDB Length = 150 Score = 28.3 bits (62), Expect = 4.4, Method: Composition-based stats. Identities = 14/66 (21%), Positives = 24/66 (36%), Gaps = 8/66 (12%) Query: 16 GTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKK 75 G V + R +++VA+K + LK L +L + S Sbjct: 20 GEVIQRFERRGYKLVAIKMM------HASEQLLQTHYEALKSLS--FFPKLVAYMSSGPV 71 Query: 76 LTLVFE 81 + +VFE Sbjct: 72 VPMVFE 77 >3FED-A nrPDB Length = 707 Score = 28.3 bits (62), Expect = 4.5, Method: Composition-based stats. Identities = 14/82 (17%), Positives = 30/82 (36%), Gaps = 8/82 (9%) Query: 189 GCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSL 248 G + EL ++ F D + LK + +++K D + + SL Sbjct: 538 GALVYELVDSKIIPFNIQDYAEALKNYAASIY--------NLSKKHDQQLTDHGVSFDSL 589 Query: 249 VNVVPKLNATGRDLLQNLLKCN 270 + V + D + L++ + Sbjct: 590 FSAVKNFSEAASDFHKRLIQVD 611 >4D0L-A nrPDB Length = 566 Score = 27.9 bits (61), Expect = 4.9, Method: Composition-based stats. Identities = 14/68 (20%), Positives = 22/68 (32%), Gaps = 10/68 (14%) Query: 86 DLKKYFDSCNGDLDPEI---VKSFLFQLLKG---LGFCHSRNVLHRDLKPQNLLINRNGE 139 L YF +G E + Q G + + H N+L++ G Sbjct: 396 SLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHN----GNILLDAEGH 451 Query: 140 LKLADFGL 147 + DFG Sbjct: 452 IIHIDFGF 459 >6GL3-A nrPDB Length = 386 Score = 27.9 bits (61), Expect = 5.0, Method: Composition-based stats. Identities = 14/68 (20%), Positives = 22/68 (32%), Gaps = 10/68 (14%) Query: 86 DLKKYFDSCNGDLDPEI---VKSFLFQLLKG---LGFCHSRNVLHRDLKPQNLLINRNGE 139 L YF +G E + Q G + + H N+L++ G Sbjct: 217 SLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHN----GNILLDAEGH 272 Query: 140 LKLADFGL 147 + DFG Sbjct: 273 IIHIDFGF 280 >2UZK-A nrPDB Length = 97 Score = 27.9 bits (61), Expect = 5.1, Method: Composition-based stats. Identities = 8/36 (22%), Positives = 16/36 (44%), Gaps = 5/36 (13%) Query: 261 DLLQNLLKCNPVQRISAEEA-----LQHPYFSDFCP 291 DL+ ++ +P +R++ + PYF D Sbjct: 8 DLITRAIESSPDKRLTLSQIYEWMVRCVPYFKDKGD 43 >5C4G-E nrPDB Length = 529 Score = 27.9 bits (61), Expect = 5.9, Method: Composition-based stats. Identities = 14/68 (20%), Positives = 22/68 (32%), Gaps = 10/68 (14%) Query: 86 DLKKYFDSCNGDLDPEI---VKSFLFQLLKG---LGFCHSRNVLHRDLKPQNLLINRNGE 139 L YF +G E + Q G + + H N+L++ G Sbjct: 359 SLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHN----GNILLDAEGH 414 Query: 140 LKLADFGL 147 + DFG Sbjct: 415 IIHIDFGF 422 >3F7W-A nrPDB Length = 288 Score = 27.5 bits (60), Expect = 6.8, Method: Composition-based stats. Identities = 14/67 (20%), Positives = 26/67 (38%), Gaps = 7/67 (10%) Query: 82 FCDQDLKKYFDSC--NGDLDPEIVKSFLFQLLKGLGFC----HSRNVLHRDLKPQNLLIN 135 + +Q + Y G L P V+ + ++L L +H DL N+L Sbjct: 145 YAEQRILPYLRRAADRGALTPGDVR-LVEKVLDALDHLAGDPEPPARIHGDLWNGNVLWQ 203 Query: 136 RNGELKL 142 +G + + Sbjct: 204 DDGAVVI 210 >2ICU-A nrPDB Length = 229 Score = 27.5 bits (60), Expect = 6.9, Method: Composition-based stats. Identities = 10/38 (26%), Positives = 15/38 (39%) Query: 76 LTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKG 113 +V DQ L D L PE + ++ Q + G Sbjct: 152 FLIVTAAADQGLVDIHDRRPLVLSPEAAREWMRQEISG 189 >4FDJ-A nrPDB Length = 502 Score = 27.5 bits (60), Expect = 7.5, Method: Composition-based stats. Identities = 20/125 (16%), Positives = 36/125 (28%), Gaps = 30/125 (24%) Query: 170 PDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPG--NDVDDQLKRIFRLLGTPTEEQW 227 P++L A S + W G RP F + D+ G + Sbjct: 99 PELLKKAGYVSKIVGKWHLGH---------RPQFHPLKHGFDEWFGSPNCHFGPYDNKAR 149 Query: 228 PSMTKLPDYKPYPMYPATTSLVNVVPKLN------ATGRDLLQNLLKCNPVQRISAEEAL 281 P++ D++ Y + + N D ++ +A Sbjct: 150 PNIPVYRDWEMVGRYYEEFPINLKTGEANLTQIYLQEALDFIKR-------------QAR 196 Query: 282 QHPYF 286 HP+F Sbjct: 197 HHPFF 201 >6DFL-A nrPDB Length = 259 Score = 27.5 bits (60), Expect = 7.6, Method: Composition-based stats. Identities = 15/75 (20%), Positives = 30/75 (40%), Gaps = 3/75 (4%) Query: 77 TLVFE-FCDQDLKKYF--DSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLL 133 +V E + F D P + ++ + + + +G H V HRD + L Sbjct: 111 FIVTEELAPTVDLEVFSQDWRERPPPPRLKRALVEAVARMVGDMHRAGVNHRDCYICHFL 170 Query: 134 INRNGELKLADFGLA 148 ++ + + DF L+ Sbjct: 171 LHTDKPVSADDFRLS 185 >5XGF-A nrPDB Length = 300 Score = 27.1 bits (59), Expect = 9.4, Method: Composition-based stats. Identities = 19/90 (21%), Positives = 33/90 (36%), Gaps = 11/90 (12%) Query: 30 VALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHD-VLHSDKKLT-LVFEFCDQDL 87 A K ++ +D + +EI + K + + HS ++ L+F L Sbjct: 174 YAEKVLQNVKEDNEKDEAKRQEILIAKTFNFYDYMLFQRLAFHSGNQIYGLIF----NGL 229 Query: 88 KKYFDSCNG-----DLDPEIVKSFLFQLLK 112 KK +D E+ F QLL+ Sbjct: 230 KKLYDRVGSYYFSNPASRELALKFYHQLLE 259 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.316 0.156 0.505 Lambda K H 0.267 0.0479 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 13,714,766 Number of Sequences: 36641 Number of extensions: 601053 Number of successful extensions: 5577 Number of sequences better than 10.0: 522 Number of HSP's better than 10.0 without gapping: 944 Number of HSP's successfully gapped in prelim test: 45 Number of HSP's that attempted gapping in prelim test: 1610 Number of HSP's gapped (non-prelim): 1206 length of query: 292 length of database: 10,336,785 effective HSP length: 96 effective length of query: 196 effective length of database: 6,819,249 effective search space: 1336572804 effective search space used: 1336572804 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.4 bits) S2: 59 (27.1 bits)