BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q00534 (326 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 1G3N-A nrPDB 674 0.0 2W96-B nrPDB 439 e-123 2BPM-A nrPDB 274 3e-74 6GU6-A nrPDB 264 3e-71 3NIZ-A nrPDB 262 2e-70 1V0B-A nrPDB 260 7e-70 4AU8-A nrPDB 244 4e-65 4KRC-A nrPDB 227 5e-60 3GC0-A nrPDB 221 3e-58 5G6V-A nrPDB 216 1e-56 4NST-A nrPDB 199 1e-51 5EFQ-A nrPDB 199 1e-51 1UA2-A nrPDB 195 2e-50 3MIA-A nrPDB 191 3e-49 4AGU-A nrPDB 187 6e-48 4BBM-A nrPDB 183 7e-47 5NGU-A nrPDB 181 3e-46 6DTL-A nrPDB 181 4e-46 2F9G-A nrPDB 181 4e-46 4QNY-A nrPDB 179 2e-45 4QTB-A nrPDB 178 3e-45 4BGQ-A nrPDB 175 2e-44 3ZDU-A nrPDB 172 1e-43 5Z33-A nrPDB 172 2e-43 4MYG-A nrPDB 169 2e-42 1CM8-A nrPDB 167 4e-42 4EWQ-A nrPDB 167 5e-42 3PG1-A nrPDB 166 1e-41 4ZSG-A nrPDB 166 2e-41 3OZ6-A nrPDB 165 2e-41 4IC8-A nrPDB 165 3e-41 3NIE-A nrPDB 162 2e-40 4CRL-A nrPDB 162 3e-40 3GC9-A nrPDB 160 8e-40 3OHT-A nrPDB 160 9e-40 2I6L-A nrPDB 158 3e-39 3N9X-A nrPDB 158 4e-39 3FI2-A nrPDB 156 1e-38 1JNK-A nrPDB 156 1e-38 3E7O-A nrPDB 153 1e-37 4O2Z-A nrPDB 152 1e-37 4E7W-A nrPDB 147 7e-36 3RP9-A nrPDB 146 1e-35 3E3P-A nrPDB 145 2e-35 2XS0-A nrPDB 145 2e-35 3EB0-A nrPDB 145 2e-35 5AWM-A nrPDB 140 6e-34 5ZTN-A nrPDB 133 1e-31 5Y86-A nrPDB 132 3e-31 5X8I-B nrPDB 130 7e-31 5AIR-A nrPDB 128 4e-30 4LFI-A nrPDB 128 4e-30 2PVN-A nrPDB 126 1e-29 5UNP-A nrPDB 122 3e-28 5XVU-A nrPDB 120 9e-28 3RAW-A nrPDB 119 2e-27 6O6Q-A nrPDB 119 2e-27 3LIJ-A nrPDB 117 5e-27 6FYV-A nrPDB 115 2e-26 3NCG-A nrPDB 115 2e-26 6EII-A nrPDB 115 4e-26 4MD7-E nrPDB 114 5e-26 3DFA-A nrPDB 114 5e-26 6HMD-A nrPDB 112 2e-25 4RGJ-A nrPDB 112 2e-25 2WO6-A nrPDB 111 3e-25 4LG4-A nrPDB 109 2e-24 6AO5-A nrPDB 109 2e-24 4IAN-A nrPDB 109 2e-24 6FD3-A nrPDB 108 3e-24 3HZT-A nrPDB 108 4e-24 3DXN-A nrPDB 108 5e-24 2WQN-A nrPDB 108 5e-24 5JN2-A nrPDB 107 6e-24 2XNP-A nrPDB 107 9e-24 3COM-A nrPDB 106 1e-23 5YKS-A nrPDB 106 2e-23 3MA6-A nrPDB 105 3e-23 4FG9-A nrPDB 104 6e-23 6QAU-A nrPDB 103 1e-22 4MVF-A nrPDB 102 2e-22 3Q53-A nrPDB 102 2e-22 3MN3-A nrPDB 102 2e-22 3Q5I-A nrPDB 102 3e-22 4QMW-A nrPDB 102 3e-22 2GCD-A nrPDB 101 4e-22 5JZN-A nrPDB 101 4e-22 2W4O-A nrPDB 101 4e-22 1U5R-A nrPDB 101 4e-22 4KS7-A nrPDB 101 5e-22 2JD5-A nrPDB 100 8e-22 6HXF-B nrPDB 100 8e-22 2VN9-A nrPDB 100 9e-22 4UZD-A nrPDB 100 1e-21 3GUB-A nrPDB 99 2e-21 4WNO-A nrPDB 99 2e-21 2J90-A nrPDB 99 2e-21 3TAC-A nrPDB 99 2e-21 2F57-A nrPDB 98 4e-21 2XIK-A nrPDB 98 4e-21 3H4J-B nrPDB 98 5e-21 4APC-A nrPDB 98 6e-21 2X4F-A nrPDB 97 9e-21 2V7O-A nrPDB 97 9e-21 4JXF-A nrPDB 97 1e-20 3SOA-A nrPDB 97 1e-20 2YAB-A nrPDB 96 2e-20 5U6Y-A nrPDB 96 2e-20 2JAM-A nrPDB 96 2e-20 4CZT-A nrPDB 96 2e-20 2X7G-A nrPDB 96 2e-20 2VZ6-A nrPDB 96 2e-20 3BHH-A nrPDB 96 2e-20 5FG8-A nrPDB 96 3e-20 3ORZ-A nrPDB 96 3e-20 2Z7Q-A nrPDB 96 3e-20 6CMJ-A nrPDB 95 4e-20 6FDY-U nrPDB 94 8e-20 1ZWS-A nrPDB 94 8e-20 3D2K-A nrPDB 94 8e-20 2JC6-A nrPDB 94 8e-20 4WUA-A nrPDB 94 8e-20 2A27-A nrPDB 94 1e-19 4B8L-A nrPDB 94 1e-19 6E2O-A nrPDB 93 2e-19 3KK8-A nrPDB 93 2e-19 4XBR-A nrPDB 93 2e-19 2BDW-A nrPDB 92 2e-19 5J5T-A nrPDB 92 2e-19 4L42-A nrPDB 92 3e-19 5D9K-A nrPDB 92 3e-19 5XZW-A nrPDB 92 3e-19 2UV2-A nrPDB 92 3e-19 2Q0N-A nrPDB 92 4e-19 4RLP-A nrPDB 92 4e-19 6DBN-A nrPDB 92 4e-19 4FIE-A nrPDB 92 4e-19 4JDH-A nrPDB 92 4e-19 5D7A-A nrPDB 91 8e-19 2Y7J-A nrPDB 91 8e-19 1S9I-A nrPDB 91 9e-19 4YZB-A nrPDB 91 1e-18 4AN9-A nrPDB 90 1e-18 1PHK-A nrPDB 90 1e-18 2A1A-B nrPDB 90 2e-18 6CQF-A nrPDB 90 2e-18 5VO2-A nrPDB 90 2e-18 4E93-A nrPDB 90 2e-18 3EQC-A nrPDB 89 2e-18 5KKR-C nrPDB 89 2e-18 2WTK-C nrPDB 89 2e-18 4YNZ-A nrPDB 89 2e-18 4C59-A nrPDB 89 2e-18 5YV8-A nrPDB 89 3e-18 4FR4-A nrPDB 89 3e-18 3VN9-A nrPDB 89 3e-18 4RED-A nrPDB 89 3e-18 1LUF-A nrPDB 89 3e-18 4REW-A nrPDB 89 3e-18 3UTO-A nrPDB 89 3e-18 1KOA-A nrPDB 89 4e-18 4CFH-A nrPDB 88 5e-18 5F9E-A nrPDB 88 5e-18 4AF3-A nrPDB 88 5e-18 1ZXE-A nrPDB 88 6e-18 5ES1-A nrPDB 88 6e-18 2QNJ-A nrPDB 87 7e-18 4PL5-B nrPDB 87 8e-18 3HMP-A nrPDB 87 8e-18 6GVJ-A nrPDB 87 8e-18 3LM0-A nrPDB 87 9e-18 4FZF-B nrPDB 87 1e-17 4CSV-A nrPDB 87 1e-17 4PDS-A nrPDB 87 1e-17 2PSQ-A nrPDB 87 1e-17 5EG3-A nrPDB 87 1e-17 2BRG-A nrPDB 87 1e-17 4CFF-A nrPDB 87 1e-17 5KZ7-A nrPDB 87 1e-17 5EZV-A nrPDB 86 1e-17 3LLT-A nrPDB 86 2e-17 3GQL-A nrPDB 86 3e-17 3FME-A nrPDB 86 3e-17 6HV0-A nrPDB 86 3e-17 5AP3-A nrPDB 86 3e-17 4D28-A nrPDB 85 4e-17 3ORP-A nrPDB 85 4e-17 3TT0-A nrPDB 85 4e-17 2ZMD-A nrPDB 85 4e-17 3HKO-A nrPDB 85 5e-17 2W1I-A nrPDB 85 5e-17 3IO7-A nrPDB 85 5e-17 2YZA-A nrPDB 85 5e-17 4UY9-A nrPDB 84 7e-17 4KIK-B nrPDB 84 8e-17 5WAX-A nrPDB 84 8e-17 5A46-A nrPDB 84 9e-17 3DTC-A nrPDB 84 1e-16 1KOB-A nrPDB 83 1e-16 3UIU-A nrPDB 83 2e-16 3I6U-A nrPDB 82 2e-16 4EQM-A nrPDB 82 2e-16 6C9D-A nrPDB 82 3e-16 2HAK-A nrPDB 82 3e-16 4TNB-A nrPDB 82 4e-16 2YCR-A nrPDB 82 4e-16 6CCF-A nrPDB 82 4e-16 4GS6-A nrPDB 81 5e-16 4C0T-A nrPDB 81 5e-16 2BUJ-A nrPDB 81 7e-16 3ZZW-A nrPDB 81 8e-16 3UDB-A nrPDB 80 9e-16 3F3Z-A nrPDB 80 9e-16 1FOT-A nrPDB 80 1e-15 4U41-A nrPDB 80 1e-15 5AMN-A nrPDB 80 1e-15 3PVW-A nrPDB 80 1e-15 5UUU-A nrPDB 80 2e-15 3TXO-A nrPDB 79 2e-15 5LOH-A nrPDB 79 2e-15 3IS5-A nrPDB 79 2e-15 3CJF-A nrPDB 79 2e-15 3QA8-A nrPDB 79 2e-15 4YHJ-A nrPDB 79 3e-15 5DYK-A nrPDB 79 4e-15 4K33-A nrPDB 79 4e-15 5O0Y-A nrPDB 78 4e-15 3A8W-A nrPDB 78 5e-15 3KN6-A nrPDB 78 6e-15 1FVR-A nrPDB 78 6e-15 2HW6-A nrPDB 78 6e-15 4XCU-A nrPDB 78 7e-15 5X02-A nrPDB 77 7e-15 4AT3-A nrPDB 77 9e-15 3HDN-A nrPDB 77 1e-14 4XUF-A nrPDB 77 1e-14 3ALO-A nrPDB 77 1e-14 5FET-A nrPDB 77 1e-14 4LRM-A nrPDB 77 1e-14 4M7I-A nrPDB 77 1e-14 3QGY-A nrPDB 77 1e-14 3DLS-A nrPDB 76 2e-14 4I6B-A nrPDB 76 2e-14 4XLV-A nrPDB 76 2e-14 5H2U-A nrPDB 76 2e-14 4PWN-A nrPDB 76 2e-14 3FXW-A nrPDB 76 2e-14 5B2L-A nrPDB 76 2e-14 4NIF-A nrPDB 76 2e-14 3UC3-A nrPDB 76 3e-14 2RIO-A nrPDB 75 3e-14 3ZUT-A nrPDB 75 3e-14 2OZA-A nrPDB 75 3e-14 1NY3-A nrPDB 75 4e-14 3NYO-A nrPDB 75 4e-14 6NPU-A nrPDB 75 4e-14 6B2Q-A nrPDB 75 5e-14 4OW8-A nrPDB 74 6e-14 4XEY-B nrPDB 74 6e-14 3KA0-A nrPDB 74 6e-14 4X3F-A nrPDB 74 6e-14 5IG1-A nrPDB 74 8e-14 3DB8-A nrPDB 74 8e-14 5L6P-A nrPDB 74 8e-14 5O2C-A nrPDB 74 8e-14 5N23-A nrPDB 74 9e-14 4UYA-A nrPDB 74 9e-14 4RA4-A nrPDB 74 9e-14 5O2B-A nrPDB 74 9e-14 2XYN-A nrPDB 74 9e-14 4B6L-A nrPDB 74 1e-13 3QUP-A nrPDB 74 1e-13 3SXS-A nrPDB 74 1e-13 6FER-A nrPDB 74 1e-13 5KMM-A nrPDB 74 1e-13 4JG6-A nrPDB 74 1e-13 4WB7-A nrPDB 74 1e-13 3LZB-A nrPDB 74 1e-13 4AW2-A nrPDB 74 1e-13 6CTH-A nrPDB 74 1e-13 4XI2-A nrPDB 74 1e-13 3TKU-A nrPDB 73 1e-13 2FO0-A nrPDB 73 1e-13 1VZO-A nrPDB 73 2e-13 5HVK-A nrPDB 73 2e-13 2OU7-A nrPDB 73 2e-13 2OGV-A nrPDB 73 2e-13 5X3F-B nrPDB 72 2e-13 4J52-A nrPDB 72 2e-13 4OLI-A nrPDB 72 2e-13 5VD3-A nrPDB 72 3e-13 4CQG-A nrPDB 72 3e-13 2DQ7-X nrPDB 72 3e-13 6DBM-A nrPDB 72 3e-13 3A4O-X nrPDB 72 3e-13 3KRL-A nrPDB 72 3e-13 6E4F-A nrPDB 72 3e-13 4EBW-A nrPDB 72 4e-13 5GNK-A nrPDB 72 4e-13 6GQK-A nrPDB 72 5e-13 3UIM-A nrPDB 72 5e-13 2J0K-A nrPDB 71 5e-13 3V5Q-A nrPDB 71 5e-13 2PMN-X nrPDB 71 6e-13 2PL0-A nrPDB 71 6e-13 6BDL-A nrPDB 71 7e-13 5FM2-A nrPDB 71 8e-13 2JDO-A nrPDB 71 8e-13 4E20-A nrPDB 70 8e-13 5GRN-A nrPDB 70 9e-13 3HNG-A nrPDB 70 1e-12 2QKW-B nrPDB 70 1e-12 4Y83-A nrPDB 70 1e-12 4HVI-A nrPDB 70 1e-12 5DBX-A nrPDB 70 1e-12 4Y93-A nrPDB 70 1e-12 5HI2-A nrPDB 70 2e-12 5MJB-A nrPDB 70 2e-12 4R7H-A nrPDB 70 2e-12 6ED6-A nrPDB 70 2e-12 3BBT-B nrPDB 70 2e-12 5TQX-A nrPDB 69 3e-12 5HLW-A nrPDB 69 3e-12 3C1X-A nrPDB 69 3e-12 3PP0-A nrPDB 69 3e-12 4F9B-A nrPDB 69 3e-12 3BEA-A nrPDB 69 3e-12 6F3F-A nrPDB 69 4e-12 6O8B-A nrPDB 68 4e-12 5U6C-A nrPDB 68 4e-12 6E9W-A nrPDB 68 5e-12 4D2V-A nrPDB 68 5e-12 4JLC-A nrPDB 68 5e-12 2HK5-A nrPDB 68 5e-12 2H8H-A nrPDB 68 5e-12 3MV5-A nrPDB 68 6e-12 5IKW-A nrPDB 68 6e-12 3DAK-A nrPDB 68 6e-12 3PPZ-A nrPDB 68 7e-12 5TOS-A nrPDB 68 7e-12 5KCV-A nrPDB 67 7e-12 5X5O-A nrPDB 67 8e-12 1AD5-A nrPDB 67 9e-12 4EUU-A nrPDB 67 9e-12 6NT9-A nrPDB 67 9e-12 5LPZ-A nrPDB 67 1e-11 2VD5-A nrPDB 67 1e-11 5U6B-A nrPDB 67 1e-11 6CKI-A nrPDB 67 1e-11 4EUT-A nrPDB 67 1e-11 5LPV-A nrPDB 67 1e-11 3PFQ-A nrPDB 66 2e-11 3G0E-A nrPDB 66 2e-11 6BXI-A nrPDB 66 2e-11 3VHK-A nrPDB 66 2e-11 2I0E-A nrPDB 66 2e-11 6FEX-A nrPDB 66 2e-11 4TPT-A nrPDB 66 2e-11 5SYS-A nrPDB 66 2e-11 3DKO-A nrPDB 66 3e-11 4OTD-A nrPDB 65 3e-11 4CRS-A nrPDB 65 3e-11 4Y12-A nrPDB 65 3e-11 3C51-A nrPDB 65 3e-11 2PZI-A nrPDB 65 4e-11 3ZBF-A nrPDB 65 4e-11 1JPA-A nrPDB 65 4e-11 1U59-A nrPDB 65 5e-11 2VWV-A nrPDB 65 6e-11 2R2P-A nrPDB 64 7e-11 5XD6-A nrPDB 64 1e-10 3PLS-A nrPDB 63 1e-10 5HIE-A nrPDB 63 1e-10 4PDO-A nrPDB 63 1e-10 3LMG-A nrPDB 63 2e-10 4NEU-A nrPDB 63 2e-10 4RT7-A nrPDB 63 2e-10 2OZO-A nrPDB 63 2e-10 1TKI-A nrPDB 63 2e-10 3MDY-A nrPDB 63 2e-10 5C26-A nrPDB 62 2e-10 1BYG-A nrPDB 62 3e-10 4YFF-A nrPDB 62 3e-10 4P5Q-A nrPDB 62 3e-10 4FL3-A nrPDB 62 3e-10 5WNO-A nrPDB 62 3e-10 1K9A-A nrPDB 62 4e-10 4H1J-A nrPDB 62 4e-10 6BSD-A nrPDB 62 5e-10 1U54-B nrPDB 62 5e-10 4HZS-A nrPDB 61 6e-10 3KUL-B nrPDB 61 6e-10 3OMV-A nrPDB 61 7e-10 5TE0-A nrPDB 60 2e-09 6J5U-C nrPDB 60 2e-09 4IDT-A nrPDB 60 2e-09 3I81-A nrPDB 59 2e-09 2Y6O-A nrPDB 59 2e-09 3QD2-B nrPDB 59 3e-09 3Q4U-A nrPDB 59 3e-09 4G3E-A nrPDB 59 4e-09 3AOX-A nrPDB 58 5e-09 5UIU-A nrPDB 57 8e-09 3G2F-A nrPDB 57 1e-08 4X7Q-B nrPDB 57 2e-08 2WTK-B nrPDB 56 2e-08 2H34-A nrPDB 56 2e-08 4RC3-A nrPDB 55 3e-08 3BGP-A nrPDB 55 4e-08 5TUR-A nrPDB 55 5e-08 4BTK-A nrPDB 55 5e-08 4NFN-A nrPDB 54 7e-08 5WNL-A nrPDB 54 8e-08 5E8V-A nrPDB 53 2e-07 6BFN-A nrPDB 52 3e-07 4M69-B nrPDB 52 4e-07 4BTF-A nrPDB 52 4e-07 1PY5-A nrPDB 52 4e-07 5OAT-A nrPDB 52 4e-07 4CYJ-A nrPDB 51 7e-07 5VDK-A nrPDB 51 7e-07 3M42-A nrPDB 50 9e-07 4F0G-A nrPDB 50 1e-06 2Y4I-B nrPDB 50 1e-06 3MY0-A nrPDB 49 4e-06 5VC6-A nrPDB 48 5e-06 5UV4-A nrPDB 47 1e-05 4M66-A nrPDB 47 1e-05 4JRN-A nrPDB 46 2e-05 4MWI-A nrPDB 46 2e-05 5M07-A nrPDB 46 2e-05 3SV0-A nrPDB 45 4e-05 2CMW-A nrPDB 44 1e-04 4LQP-A nrPDB 44 1e-04 5X18-A nrPDB 43 2e-04 2QLU-A nrPDB 42 3e-04 5AR8-A nrPDB 42 4e-04 3SOC-A nrPDB 42 5e-04 2C47-A nrPDB 41 7e-04 4NT4-A nrPDB 40 0.001 4TN6-A nrPDB 40 0.002 2CHL-A nrPDB 40 0.002 4O1O-A nrPDB 40 0.002 5L2Q-C nrPDB 40 0.002 4OAU-C nrPDB 39 0.003 4IX6-A nrPDB 39 0.003 5FQD-C nrPDB 39 0.003 2RSV-A nrPDB 39 0.003 2JII-A nrPDB 39 0.004 2LAV-A nrPDB 39 0.004 5J0A-A nrPDB 37 0.011 6G4J-A nrPDB 37 0.011 5CLR-A nrPDB 36 0.023 5UU1-A nrPDB 35 0.033 4XHH-A nrPDB 35 0.043 3Q60-A nrPDB 35 0.045 4XHL-A nrPDB 35 0.051 1CSN-A nrPDB 34 0.099 5X1R-A nrPDB 34 0.11 6EQI-C nrPDB 33 0.13 6EWX-A nrPDB 33 0.13 5VE6-A nrPDB 32 0.33 4L00-A nrPDB 32 0.38 5TX1-A nrPDB 32 0.39 4CI6-B nrPDB 32 0.40 3REP-A nrPDB 32 0.41 4AZV-A nrPDB 32 0.55 5DMZ-A nrPDB 31 0.60 4AZW-A nrPDB 31 0.81 3NNR-A nrPDB 30 1.2 3EMC-A nrPDB 30 2.1 2WFP-A nrPDB 29 2.2 5C01-A nrPDB 29 2.4 4WOV-A nrPDB 29 2.6 4L68-A nrPDB 29 3.0 2V8D-A nrPDB 29 3.1 5YPX-A nrPDB 28 4.9 6J6I-B nrPDB 28 5.0 2OBE-A nrPDB 28 5.5 3DZO-A nrPDB 28 6.0 3A9Z-A nrPDB 28 6.0 3BYV-A nrPDB 28 7.6 >1G3N-A nrPDB Length = 326 Score = 674 bits (1740), Expect = 0.0, Method: Compositional matrix adjust. Identities = 326/326 (100%), Positives = 326/326 (100%) Query: 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR 60 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR Sbjct: 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR 60 Query: 61 EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTE 120 EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTE Sbjct: 61 EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTE 120 Query: 121 TIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVV 180 TIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVV Sbjct: 121 TIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVV 180 Query: 181 VTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGE 240 VTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGE Sbjct: 181 VTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGE 240 Query: 241 EDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 EDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF Sbjct: 241 EDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 Query: 301 QDLERCKENLDSHLPPSQNTSELNTA 326 QDLERCKENLDSHLPPSQNTSELNTA Sbjct: 301 QDLERCKENLDSHLPPSQNTSELNTA 326 >2W96-B nrPDB Length = 306 Score = 439 bits (1128), Expect = e-123, Method: Compositional matrix adjust. Identities = 212/300 (70%), Positives = 244/300 (81%), Gaps = 1/300 (0%) Query: 9 ADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHL 68 A +YE VAEIG GAYG V+KARD + G FVALK VRV GEEG+P+ST+REVA+LR L Sbjct: 2 ATSRYEPVAEIGVGAYGTVYKARD-PHSGHFVALKSVRVPNGEEGLPISTVREVALLRRL 60 Query: 69 ETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQ 128 E FEHPNVVRL DVC SRTDRE K+TLVFEHVDQDL TYLDK P PG+P ETIKD+M Q Sbjct: 61 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQ 120 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAP 188 LRGLDFLH++ +VHRDLKP+NILVTS G +KLADFGLARIYS+QMAL VVVTLWYRAP Sbjct: 121 FLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALDPVVVTLWYRAP 180 Query: 189 EVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA 248 EVLLQS+YATPVD+WSVGCIFAEMFRRKPLF G+S+ DQLGKI D+IGLP E+DWPRDV+ Sbjct: 181 EVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVS 240 Query: 249 LPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKE 308 LPR AF + +P++ V +++E G LLL+ LTFNP KRISA+ AL H Y E E Sbjct: 241 LPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE 300 >2BPM-A nrPDB Length = 309 Score = 274 bits (701), Expect = 3e-74, Method: Compositional matrix adjust. Identities = 145/299 (48%), Positives = 198/299 (66%), Gaps = 13/299 (4%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 + ++ V +IGEG YG V+KAR+ K G VALK++R+ T EG+P + IRE+++L+ L Sbjct: 7 ENFQKVEKIGEGTYGVVYKARN-KLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN- 64 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130 HPN+V+L DV E KL LVFE + QDL ++D G+P IK +FQLL Sbjct: 65 --HPNIVKLLDVIHT-----ENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLL 117 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQM-ALTSVVVTLWYRAPE 189 +GL F HSHRV+HRDLKPQN+L+ + G IKLADFGLAR + + T VVTLWYRAPE Sbjct: 118 QGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPE 177 Query: 190 VLLQSS-YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA 248 +LL Y+T VD+WS+GCIFAEM R+ LF G S++DQL +I +G P E WP + Sbjct: 178 ILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS 237 Query: 249 LP--RQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLER 305 +P + +F + Q K V +DE G+ LL + L ++P KRISA +AL+HP+FQD+ + Sbjct: 238 MPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTK 296 >6GU6-A nrPDB Length = 302 Score = 264 bits (675), Expect = 3e-71, Method: Compositional matrix adjust. Identities = 139/300 (46%), Positives = 198/300 (66%), Gaps = 16/300 (5%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 + Y + +IGEG YG V+K R K G+ VA+K++R+++ EEG+P + IRE+++L+ L Sbjct: 7 EDYTKIEKIGEGTYGVVYKGRH-KTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELR- 64 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPG--VPTETIKDMMFQ 128 HPN+V L DV ++++L L+FE + DL YLD +P PG + + +K ++Q Sbjct: 65 --HPNIVSLQDVLM-----QDSRLYLIFEFLSMDLKKYLDSIP-PGQYMDSSLVKSYLYQ 116 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMAL-TSVVVTLWYRA 187 +L+G+ F HS RV+HRDLKPQN+L+ G IKLADFGLAR + + + T VVTLWYR+ Sbjct: 117 ILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRS 176 Query: 188 PEVLLQSS-YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRD 246 PEVLL S+ Y+TPVD+WS+G IFAE+ +KPLF G S++DQL +I +G P E WP Sbjct: 177 PEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEV 236 Query: 247 VALP--RQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLE 304 +L + F + V ++DE G DLL K L ++PAKRIS AL+HPYF DL+ Sbjct: 237 ESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLD 296 >3NIZ-A nrPDB Length = 311 Score = 262 bits (669), Expect = 2e-70, Method: Compositional matrix adjust. Identities = 139/299 (46%), Positives = 195/299 (65%), Gaps = 16/299 (5%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 ++Y+ + ++GEG YG V+KA+D + GR VALKR+R+ +EG+P + IRE+++L+ L Sbjct: 21 EKYQKLEKVGEGTYGVVYKAKD--SQGRIVALKRIRLDAEDEGIPSTAIREISLLKELH- 77 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130 HPN+V L DV R LTLVFE +++DL LD+ + G+ IK ++QLL Sbjct: 78 --HPNIVSLIDVIHSERC-----LTLVFEFMEKDLKKVLDE-NKTGLQDSQIKIYLYQLL 129 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQM-ALTSVVVTLWYRAPE 189 RG+ H HR++HRDLKPQN+L+ S G +KLADFGLAR + + + T VVTLWYRAP+ Sbjct: 130 RGVAHCHQHRILHRDLKPQNLLINSDGALKLADFGLARAFGIPVRSYTHEVVTLWYRAPD 189 Query: 190 VLLQS-SYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA 248 VL+ S Y+T VD+WS+GCIFAEM KPLF G +D DQL KI ++G P +WP+ Sbjct: 190 VLMGSKKYSTSVDIWSIGCIFAEMITGKPLFPGVTDDDQLPKIFSILGTPNPREWPQVQE 249 Query: 249 LP---RQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLE 304 LP ++ F +P + + G DLL L F+P KRISA A++HPYF+DL+ Sbjct: 250 LPLWKQRTFQVFEKKPWSSIIPGFCQEGIDLLSNMLCFDPNKRISARDAMNHPYFKDLD 308 >1V0B-A nrPDB Length = 288 Score = 260 bits (664), Expect = 7e-70, Method: Compositional matrix adjust. Identities = 135/296 (45%), Positives = 192/296 (64%), Gaps = 15/296 (5%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 ++Y + +IGEG YG V+KA++ N G ALK++R++ +EG+P +TIRE+++L+ L+ Sbjct: 2 EKYHGLEKIGEGTYGVVYKAQN--NYGETFALKKIRLEKEDEGIPSTTIREISILKELK- 58 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130 H N+V+L+DV + +L LVFEH+DQDL LD V E G+ + T K + QLL Sbjct: 59 --HSNIVKLYDVIHTKK-----RLVLVFEHLDQDLKKLLD-VCEGGLESVTAKSFLLQLL 110 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQM-ALTSVVVTLWYRAPE 189 G+ + H RV+HRDLKPQN+L+ G++K+ADFGLAR + + T VVTLWYRAP+ Sbjct: 111 NGIAYCHDRRVLHRDLKPQNLLINREGELKIADFGLARAFGIPVRKYTHEVVTLWYRAPD 170 Query: 190 VLLQS-SYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA 248 VL+ S Y+T +D+WSVGCIFAEM PLF G S+ DQL +I ++G P ++WP Sbjct: 171 VLMGSKKYSTTIDIWSVGCIFAEMVNGAPLFPGVSEADQLMRIFRILGTPNSKNWPNVTE 230 Query: 249 LPRQ--AFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQD 302 LP+ F P E F+ +DE G DLL K L +P +RI+A AL H YF++ Sbjct: 231 LPKYDPNFTVYEPLPWESFLKGLDESGIDLLSKMLKLDPNQRITAKQALEHAYFKE 286 >4AU8-A nrPDB Length = 296 Score = 244 bits (623), Expect = 4e-65, Method: Compositional matrix adjust. Identities = 136/300 (45%), Positives = 182/300 (60%), Gaps = 15/300 (5%) Query: 9 ADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHL 68 Q+YE + +IGEG YG VFKA++ + VALKRVR+ +EG+P S +RE+ +L+ L Sbjct: 4 GSQKYEKLEKIGEGTYGTVFKAKN-RETHEIVALKRVRLDDDDEGVPSSALREICLLKEL 62 Query: 69 ETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQ 128 + H N+VRL DV + KLTLVFE DQDL Y D + E +K +FQ Sbjct: 63 K---HKNIVRLHDV-----LHSDKKLTLVFEFCDQDLKKYFDSC-NGDLDPEIVKSFLFQ 113 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSV-VVTLWYRA 187 LL+GL F HS V+HRDLKPQN+L+ +G++KLADFGLAR + + S VVTLWYR Sbjct: 114 LLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRP 173 Query: 188 PEVLLQSS-YATPVDLWSVGCIFAEMFRR-KPLFRGSSDVDQLGKILDVIGLPGEEDWPR 245 P+VL + Y+T +D+WS GCIFAE+ +PLF G+ DQL +I ++G P EE WP Sbjct: 174 PDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPS 233 Query: 246 DVALPRQAFHS--KSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDL 303 LP + + + V ++ G+DLL L NP +RISA AL HPYF D Sbjct: 234 MTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDF 293 >4KRC-A nrPDB Length = 317 Score = 227 bits (579), Expect = 5e-60, Method: Compositional matrix adjust. Identities = 127/315 (40%), Positives = 183/315 (58%), Gaps = 39/315 (12%) Query: 9 ADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHL 68 + Q++ + ++G G Y V+K + K G +VALK V++ + EEG P + IRE+++++ L Sbjct: 3 SSSQFKQLEKLGNGTYATVYKGLN-KTTGVYVALKEVKLDS-EEGTPSTAIREISLMKEL 60 Query: 69 ETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLD-----KVPEPGVPTETIK 123 + H N+VRL+DV E KLTLVFE +D DL Y+D P G+ +K Sbjct: 61 K---HENIVRLYDVIHT-----ENKLTLVFEFMDNDLKKYMDSRTVGNTPR-GLELNLVK 111 Query: 124 DMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQM-ALTSVVVT 182 +QLL+GL F H ++++HRDLKPQN+L+ GQ+KL DFGLAR + + +S VVT Sbjct: 112 YFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVT 171 Query: 183 LWYRAPEVLLQS-SYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEE 241 LWYRAP+VL+ S +Y+T +D+WS GCI AEM KPLF G++D +QL I D++G P E Sbjct: 172 LWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNES 231 Query: 242 DWPRDVALP--------------RQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAK 287 WP LP RQ + +P++ + D L L NP Sbjct: 232 LWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLM-------DFLHGLLQLNPDM 284 Query: 288 RISAYSALSHPYFQD 302 R+SA AL HP+F + Sbjct: 285 RLSAKQALHHPWFAE 299 >3GC0-A nrPDB Length = 329 Score = 221 bits (564), Expect = 3e-58, Method: Compositional matrix adjust. Identities = 127/299 (42%), Positives = 188/299 (62%), Gaps = 21/299 (7%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETF 71 +Y + ++GEG YG+V+KA D VA+KR+R++ EEG+P + IREV++L+ L+ Sbjct: 35 RYRRITKLGEGTYGEVYKAIDTVTN-ETVAIKRIRLEHEEEGVPGTAIREVSLLKELQ-- 91 Query: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLR 131 H N++ L V +L L+FE+ + DL Y+DK P+ V IK ++QL+ Sbjct: 92 -HRNIIELKSVI-----HHNHRLHLIFEYAENDLKKYMDKNPD--VSMRVIKSFLYQLIN 143 Query: 132 GLDFLHSHRVVHRDLKPQNILVTSSGQ-----IKLADFGLARIYSFQM-ALTSVVVTLWY 185 G++F HS R +HRDLKPQN+L++ S +K+ DFGLAR + + T ++TLWY Sbjct: 144 GVNFCHSRRCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQFTHEIITLWY 203 Query: 186 RAPEVLLQS-SYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWP 244 R PE+LL S Y+T VD+WS+ CI+AEM + PLF G S++DQL KI +V+GLP + WP Sbjct: 204 RPPEILLGSRHYSTSVDIWSIACIWAEMLMKTPLFPGDSEIDQLFKIFEVLGLPDDTTWP 263 Query: 245 RDVALP--RQAFHSKSAQPIEKFV-TDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 ALP +Q+F + +++ + +D+ G DLL L +P KRISA +AL HPYF Sbjct: 264 GVTALPDWKQSFPKFRGKTLKRVLGALLDDEGLDLLTAMLEMDPVKRISAKNALEHPYF 322 >5G6V-A nrPDB Length = 324 Score = 216 bits (549), Expect = 1e-56, Method: Compositional matrix adjust. Identities = 127/300 (42%), Positives = 176/300 (58%), Gaps = 20/300 (6%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 + Y + ++GEG Y V+K + K VALK +R++ EEG P + IREV++L+ L+ Sbjct: 2 ETYIKLDKLGEGTYATVYKGKS-KLTDNLVALKEIRLE-HEEGAPCTAIREVSLLKDLK- 58 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130 H N+V L D+ E LTLVFE++D+DL YLD + +K +FQLL Sbjct: 59 --HANIVTLHDIIHT-----EKSLTLVFEYLDKDLKQYLDDCGNI-INMHNVKLFLFQLL 110 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSF-QMALTSVVVTLWYRAPE 189 RGL + H +V+HRDLKPQN+L+ G++KLADFGLAR S + VVTLWYR P+ Sbjct: 111 RGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYDNEVVTLWYRPPD 170 Query: 190 VLLQSS-YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA 248 +LL S+ Y+T +D+W VGCIF EM +PLF GS+ +QL I ++G P EE WP Sbjct: 171 ILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPG--I 228 Query: 249 LPRQAFHSKS-----AQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDL 303 L + F + + A+ + +D G DLL K L F RISA A+ HP+F L Sbjct: 229 LSNEEFKTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSL 288 >4NST-A nrPDB Length = 351 Score = 199 bits (507), Expect = 1e-51, Method: Compositional matrix adjust. Identities = 127/340 (37%), Positives = 191/340 (56%), Gaps = 31/340 (9%) Query: 2 EKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIRE 61 E D R +++ + IGEG YG+V+KA+D K+ G VALK+VR+ +EG P++ IRE Sbjct: 4 ESDWGKRCVDKFDIIGIIGEGTYGQVYKAKD-KDTGELVALKKVRLDNEKEGFPITAIRE 62 Query: 62 VAVLRHLETFEHPNVVRLFDVCTVSRTDRETK-----LTLVFEHVDQDLTTYLDKVPEPG 116 + +LR L H +VV + ++ T + + K LVFE++D DL L E G Sbjct: 63 IKILRQLI---HRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLL----ESG 115 Query: 117 V---PTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQ 173 + + IK M QL+ GL++ H +HRD+K NIL+ +SGQIKLADFGLAR+Y+ + Sbjct: 116 LVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSE 175 Query: 174 MA--LTSVVVTLWYRAPEVLLQSSYATP-VDLWSVGCIFAEMFRRKPLFRGSSDVDQLGK 230 + T+ V+TLWYR PE+LL TP +D+WS GCI E+F +KP+F+ + ++ QL Sbjct: 176 ESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLEL 235 Query: 231 ILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKF-------VTDIDELGKDLLLKCLTF 283 I + G P WP + LP + + +P +++ + I DLL LT Sbjct: 236 ISRLCGSPCPAVWPDVIKLP----YFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTL 291 Query: 284 NPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSEL 323 +P+KR +A L + +D+E K LP Q+ EL Sbjct: 292 DPSKRCTAEQTLQSDFLKDVELSK-MAPPDLPHWQDCHEL 330 >5EFQ-A nrPDB Length = 347 Score = 199 bits (506), Expect = 1e-51, Method: Compositional matrix adjust. Identities = 123/331 (37%), Positives = 184/331 (55%), Gaps = 44/331 (13%) Query: 8 RADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRH 67 R +++ + IGEG YG+V+KARD K+ G VALK+VR+ +EG P++ IRE+ +LR Sbjct: 8 RCVDKFDIIGIIGEGTYGQVYKARD-KDTGEMVALKKVRLDNEKEGFPITAIREIKILRQ 66 Query: 68 LETFEHPNVVRLFDVCTVSRTDRETKLT---------LVFEHVDQDLTTYLDKVPEPGV- 117 L H +++ + ++ T D+E L LVFE++D DL L E G+ Sbjct: 67 LT---HQSIINMKEIVT----DKEDALDFKKDKGAFYLVFEYMDHDLMGLL----ESGLV 115 Query: 118 --PTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMA 175 IK M QL+ GLD+ H +HRD+K NIL+ + GQIKLADFGLAR+YS + + Sbjct: 116 HFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEES 175 Query: 176 --LTSVVVTLWYRAPEVLLQSSYATP-VDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKIL 232 T+ V+TLWYR PE+LL TP +D+WS GCI E+F +KP+F+ + ++ QL I Sbjct: 176 RPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELIS 235 Query: 233 DVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDE-------LGKDLLLKCLTFNP 285 + G P WP + LP + + +P +++ + E DL L +P Sbjct: 236 RICGSPCPAVWPDVIKLP----YFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDP 291 Query: 286 AKRISAYSALSHPYFQDLERCKENLDSHLPP 316 +KR +A AL + +D+E S +PP Sbjct: 292 SKRCTAEQALQCEFLRDVE------PSKMPP 316 >1UA2-A nrPDB Length = 346 Score = 195 bits (496), Expect = 2e-50, Method: Compositional matrix adjust. Identities = 112/298 (37%), Positives = 170/298 (57%), Gaps = 16/298 (5%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRV---QTGEEGMPLSTIREVAVLRH 67 ++YE + +GEG + V+KARD KN + VA+K++++ ++G+ + +RE+ +L+ Sbjct: 10 KRYEKLDFLGEGQFATVYKARD-KNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 Query: 68 LETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMF 127 L HPN++ L D ++ ++LVF+ ++ DL + P+ IK M Sbjct: 69 LS---HPNIIGLLDAF-----GHKSNISLVFDFMETDLEVIIKDNSLVLTPSH-IKAYML 119 Query: 128 QLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY-SFQMALTSVVVTLWYR 186 L+GL++LH H ++HRDLKP N+L+ +G +KLADFGLA+ + S A T VVT WYR Sbjct: 120 MTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYR 179 Query: 187 APEVLLQSS-YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPR 245 APE+L + Y VD+W+VGCI AE+ R P G SD+DQL +I + +G P EE WP Sbjct: 180 APELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPD 239 Query: 246 DVALPRQ-AFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQD 302 +LP F S P+ + + DL+ FNP RI+A AL YF + Sbjct: 240 MCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSN 297 >3MIA-A nrPDB Length = 351 Score = 191 bits (486), Expect = 3e-49, Method: Compositional matrix adjust. Identities = 119/311 (38%), Positives = 179/311 (57%), Gaps = 23/311 (7%) Query: 6 LCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVL 65 C +YE +A+IG+G +G+VFKAR K G + VALK+V ++ +EG P++ +RE+ +L Sbjct: 12 FCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQK-VALKKVLMENEKEGFPITALREIKIL 70 Query: 66 RHLETFEHPNVVRLFDVC--TVSRTDR-ETKLTLVFEHVDQDLTTYLDKVPEPGVPTETI 122 + L+ H NVV L ++C S +R + + LVF+ + DL L V +E I Sbjct: 71 QLLK---HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSE-I 126 Query: 123 KDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMA-----LT 177 K +M LL GL ++H ++++HRD+K N+L+T G +KLADFGLAR +S T Sbjct: 127 KRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYT 186 Query: 178 SVVVTLWYRAPEVLL-QSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIG 236 + VVTLWYR PE+LL + Y P+DLW GCI AEM+ R P+ +G+++ QL I + G Sbjct: 187 NRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCG 246 Query: 237 LPGEEDWPR--DVALPR-----QAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRI 289 E WP + L + K ++ +V D L DL+ K L +PA+RI Sbjct: 247 SITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYAL--DLIDKLLVLDPAQRI 304 Query: 290 SAYSALSHPYF 300 + AL+H +F Sbjct: 305 DSDDALNHDFF 315 >4AGU-A nrPDB Length = 311 Score = 187 bits (475), Expect = 6e-48, Method: Compositional matrix adjust. Identities = 111/319 (34%), Positives = 177/319 (55%), Gaps = 24/319 (7%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 ++YE + +IGEG+YG VFK R+ ++ G+ VA+K+ + + +RE+ +L+ L+ Sbjct: 3 EKYEKIGKIGEGSYGVVFKCRN-RDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLK- 60 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130 HPN+V L +V R+ +L LVFE+ D + LD+ + GVP +K + +Q L Sbjct: 61 --HPNLVNLLEVFR-----RKRRLHLVFEYCDHTVLHELDRY-QRGVPEHLVKSITWQTL 112 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQM-ALTSVVVTLWYRAPE 189 + ++F H H +HRD+KP+NIL+T IKL DFG AR+ + V T WYR+PE Sbjct: 113 QAVNFCHKHNCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYDDEVATRWYRSPE 172 Query: 190 VLL-QSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIG--LPGEEDWPRD 246 +L+ + Y PVD+W++GC+FAE+ PL+ G SDVDQL I +G +P + Sbjct: 173 LLVGDTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQ----Q 228 Query: 247 VALPRQAFHS------KSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 V Q F + +P+E +I LL CL +P +R++ L HPYF Sbjct: 229 VFSTNQYFSGVKIPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTERLTCEQLLHHPYF 288 Query: 301 QDLERCKENLDSHLPPSQN 319 +++ ++ H P++N Sbjct: 289 ENIREIEDLAKEHDKPAEN 307 >4BBM-A nrPDB Length = 331 Score = 183 bits (465), Expect = 7e-47, Method: Compositional matrix adjust. Identities = 109/301 (36%), Positives = 168/301 (55%), Gaps = 24/301 (7%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 ++YE + +GEG+YG V K R+ K+ GR VA+K+ ++ + +RE+ +L+ L Sbjct: 25 EKYENLGLVGEGSYGMVMKCRN-KDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLR- 82 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130 H N+V L +VC ++ + LVFE VD + L+ P G+ + ++ +FQ++ Sbjct: 83 --HENLVNLLEVCK-----KKKRWYLVFEFVDHTILDDLELFPN-GLDYQVVQKYLFQII 134 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMAL-TSVVVTLWYRAPE 189 G+ F HSH ++HRD+KP+NILV+ SG +KL DFG AR + + V T WYRAPE Sbjct: 135 NGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYDDEVATRWYRAPE 194 Query: 190 VLLQS-SYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIG--LPGEEDWPRD 246 +L+ Y VD+W++GC+ EMF +PLF G SD+DQL I+ +G +P ++ Sbjct: 195 LLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNK 254 Query: 247 ------VALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 V LP K +P+E+ + E+ DL KCL +P KR L H +F Sbjct: 255 NPVFAGVRLPE----IKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFF 310 Query: 301 Q 301 Q Sbjct: 311 Q 311 >5NGU-A nrPDB Length = 381 Score = 181 bits (460), Expect = 3e-46, Method: Compositional matrix adjust. Identities = 108/299 (36%), Positives = 163/299 (54%), Gaps = 17/299 (5%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETF 71 +Y ++ IGEGAYG V A D N R VA+K++ + T+RE+ +L F Sbjct: 43 RYTNLSYIGEGAYGMVCSAYDNLNKVR-VAIKKIS-PFEHQTYCQRTLREIKILLR---F 97 Query: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLR 131 H N++ + D+ ++ + +V + ++ DL L + + I ++Q+LR Sbjct: 98 RHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKT---QHLSNDHICYFLYQILR 154 Query: 132 GLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARI----YSFQMALTSVVVTLWYRA 187 GL ++HS V+HRDLKP N+L+ ++ +K+ DFGLAR+ + LT V T WYRA Sbjct: 155 GLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRA 214 Query: 188 PEVLLQS-SYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRD 246 PE++L S Y +D+WSVGCI AEM +P+F G +DQL IL ++G P +ED Sbjct: 215 PEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 274 Query: 247 VALPRQAF----HSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQ 301 + L + + K+ P + + D DLL K LTFNP KRI AL+HPY + Sbjct: 275 INLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLE 333 >6DTL-A nrPDB Length = 364 Score = 181 bits (459), Expect = 4e-46, Method: Compositional matrix adjust. Identities = 109/305 (35%), Positives = 167/305 (54%), Gaps = 12/305 (3%) Query: 16 VAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPN 75 + IG+GAYG V A + VA+K++ + T+RE+ +LRH++ H N Sbjct: 35 IMPIGKGAYGIVCSAMN-SETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMD---HEN 90 Query: 76 VVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDF 135 +V + D+ + + + +E +D DL + + E + ++Q+LRGL + Sbjct: 91 IVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRS--NQALSEEHCQYFLYQILRGLKY 148 Query: 136 LHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSS 195 +HS V+HRDLKP N+L+ ++ +K+ DFGLAR+ S +T VVT WYRAPE+LL SS Sbjct: 149 IHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSS 208 Query: 196 -YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAF 254 Y +D+WSVGCIF E+ RKPLF G V QL ++++IG P EE+ ++ Sbjct: 209 DYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYI 268 Query: 255 HSKSAQP----IEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENL 310 P +KF T + L DL+ K LTF+P +RI+ AL+HPY L + Sbjct: 269 RQLPPYPRQSITDKFPT-VHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISDEP 327 Query: 311 DSHLP 315 + +P Sbjct: 328 ECTIP 332 >2F9G-A nrPDB Length = 353 Score = 181 bits (459), Expect = 4e-46, Method: Compositional matrix adjust. Identities = 112/318 (35%), Positives = 170/318 (53%), Gaps = 25/318 (7%) Query: 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR 60 M K + ++ + +GEGAYG V A K G VA+K++ + L T+R Sbjct: 1 MPKRIVYNISSDFQLKSLLGEGAYGVVCSATH-KPTGEIVAIKKIE-PFDKPLFALRTLR 58 Query: 61 EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTE 120 E+ +L+H F+H N++ +F++ + ++ ++ E + DL + + + Sbjct: 59 EIKILKH---FKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQ---MLSDD 112 Query: 121 TIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY---------- 170 I+ ++Q LR + LH V+HRDLKP N+L+ S+ +K+ DFGLARI Sbjct: 113 HIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEP 172 Query: 171 -SFQMALTSVVVTLWYRAPEVLLQSS-YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQL 228 Q +T V T WYRAPEV+L S+ Y+ +D+WS GCI AE+F R+P+F G QL Sbjct: 173 TGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQL 232 Query: 229 GKILDVIGLPGEEDWPRDVALPRQAFHSKS-----AQPIEKFVTDIDELGKDLLLKCLTF 283 I +IG P ++ R + PR + KS A P+EK ++ G DLL + L F Sbjct: 233 LLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVF 292 Query: 284 NPAKRISAYSALSHPYFQ 301 +PAKRI+A AL HPY Q Sbjct: 293 DPAKRITAKEALEHPYLQ 310 >4QNY-A nrPDB Length = 354 Score = 179 bits (454), Expect = 2e-45, Method: Compositional matrix adjust. Identities = 109/306 (35%), Positives = 165/306 (53%), Gaps = 14/306 (4%) Query: 6 LCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTI-REVAV 64 +CR D +Y IG G+YG V +ARD K+ R VA+KRV + EE + I RE+ + Sbjct: 15 VCRLDDRYLLERIIGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFEEVILAKRILREIKL 74 Query: 65 LRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKD 124 L H F N++ L ++ T + +V + ++ DL L E + I+ Sbjct: 75 LAH---FNDDNIIGLRNILTPEDPENFDHFYIVMDIMETDLKQVLRSGQE--LTEAHIQF 129 Query: 125 MMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMA-LTSVVVTL 183 ++Q LR L +HS V+HRD+ P NILV ++ +K+ DFGLA+ + Q +T V Sbjct: 130 FIYQALRALHIIHSAGVIHRDITPANILVNTNCDLKICDFGLAKEENDQGEYMTDYVTMR 189 Query: 184 WYRAPEVLLQSS-YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEED 242 WYRAPE++++ Y+ +D+W +GCI E+ +PLF+G V+QL KI+DVIG P EED Sbjct: 190 WYRAPELVMEDKDYSAQIDVWGIGCILGELLGSRPLFQGKDRVNQLDKIVDVIGTPSEED 249 Query: 243 WPRDVALPRQAF-----HSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSH 297 + Q + H A +++ T E DLL L FNP +RI+ A+ H Sbjct: 250 INSVGSSAAQKYLKKKSHRPQADWRQRYPTASPE-ALDLLRHMLVFNPKRRITVLQAMRH 308 Query: 298 PYFQDL 303 P+ + L Sbjct: 309 PFLEQL 314 >4QTB-A nrPDB Length = 380 Score = 178 bits (451), Expect = 3e-45, Method: Compositional matrix adjust. Identities = 110/299 (36%), Positives = 161/299 (53%), Gaps = 17/299 (5%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETF 71 +Y + IGEGAYG V A D R VA+K++ + T+RE+ +L F Sbjct: 42 RYTQLQYIGEGAYGMVSSAYDHVRKTR-VAIKKIS-PFEHQTYCQRTLREIQILLR---F 96 Query: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLR 131 H NV+ + D+ S + + +V + ++ DL L + + I ++Q+LR Sbjct: 97 RHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKS---QQLSNDHICYFLYQILR 153 Query: 132 GLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARI----YSFQMALTSVVVTLWYRA 187 GL ++HS V+HRDLKP N+L+ ++ +K+ DFGLARI + LT V T WYRA Sbjct: 154 GLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRA 213 Query: 188 PEVLLQS-SYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRD 246 PE++L S Y +D+WSVGCI AEM +P+F G +DQL IL ++G P +ED Sbjct: 214 PEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 273 Query: 247 VALPR----QAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQ 301 + + Q+ SK+ K D DLL + LTFNP KRI+ AL+HPY + Sbjct: 274 INMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLE 332 >4BGQ-A nrPDB Length = 304 Score = 175 bits (443), Expect = 2e-44, Method: Compositional matrix adjust. Identities = 108/300 (36%), Positives = 168/300 (56%), Gaps = 21/300 (7%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 ++E + +GEGAYG V K R K VA+K+ + E + +T+RE+ +LR T Sbjct: 12 NKFEILGVVGEGAYGVVLKCRH-KETHEIVAIKKFKDSEENEEVKETTLRELKMLR---T 67 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130 + N+V L + R KL LVFE+V++++ L+++P GVP E +K ++QL+ Sbjct: 68 LKQENIVELKEAFR-----RRGKLYLVFEYVEKNMLELLEEMPN-GVPPEKVKSYIYQLI 121 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYS--FQMALTSVVVTLWYRAP 188 + + + H + +VHRD+KP+N+L++ + +KL DFG AR S V T WYR+P Sbjct: 122 KAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYDEEVATRWYRSP 181 Query: 189 EVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIG-LPGEE-----D 242 E+LL + Y VD+WSVGCI E+ +PLF G S++DQL I V+G LP E+ Sbjct: 182 ELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYS 241 Query: 243 WPRDVALPRQAF-HSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQ 301 PR L A H +S + +++ ++ + DL+ L +PA R L+HP FQ Sbjct: 242 NPRFHGLRFPAVNHPQSLE--RRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQ 299 >3ZDU-A nrPDB Length = 325 Score = 172 bits (437), Expect = 1e-43, Method: Compositional matrix adjust. Identities = 110/302 (36%), Positives = 171/302 (56%), Gaps = 29/302 (9%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 + YE + ++GEG+YG V K + KN G+ VA+K + + E+ + +RE+ L+ Sbjct: 3 EMYETLGKVGEGSYGTVMKCKH-KNTGQIVAIK-IFYERPEQSVNKIAMREIKFLKQ--- 57 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPE--PGVPTETIKDMMFQ 128 F H N+V L +V ++ K+ LVFE +D T LD++ G+ ++ ++ +FQ Sbjct: 58 FHHENLVNLIEVFR-----QKKKIHLVFEFIDH---TVLDELQHYCHGLESKRLRKYLFQ 109 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALT-SVVVTLWYRA 187 +LR +D+LHS+ ++HRD+KP+NILV+ SG KL DFG AR + + V T WYRA Sbjct: 110 ILRAIDYLHSNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYDDEVATRWYRA 169 Query: 188 PEVLLQ-SSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIG--------LP 238 PE++L+ +SY PVD+W++GC+ EM P SSD+D L KI+ +G + Sbjct: 170 PELVLKDTSYGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIF 229 Query: 239 GEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHP 298 + V LP Q H K+A+ K ++ L D++ CL +PA RIS+ L H Sbjct: 230 SKSPIFAGVVLP-QVQHPKNAR---KKYPKLNGLLADIVHACLQIDPADRISSSDLLHHE 285 Query: 299 YF 300 YF Sbjct: 286 YF 287 >5Z33-A nrPDB Length = 425 Score = 172 bits (435), Expect = 2e-43, Method: Compositional matrix adjust. Identities = 105/303 (34%), Positives = 164/303 (54%), Gaps = 18/303 (5%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLE 69 D++Y E+G+GAYG V A + VA+K+V ++ + +RE+ +L+H Sbjct: 30 DERYTVTKELGQGAYGIVCAAVN-NQTSEGVAIKKVTNVFSKKILAKRALREIKLLQHFR 88 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQL 129 H N+ L+D+ + R D + L E ++ DL + + +P + + ++Q+ Sbjct: 89 G--HRNITCLYDM-DIPRPDNFNETYLYEELMECDLAAII-RSGQP-LTDAHFQSFIYQI 143 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMA-----LTSVVVTLW 184 L GL ++HS V+HRDLKP N+LV + ++K+ DFGLAR +S +T V T W Sbjct: 144 LCGLKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSVDPEENAGYMTEYVATRW 203 Query: 185 YRAPEVLLQ-SSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDW 243 YRAPE++L SY +D+WSVGCI AE+ +P F+G VDQL +IL ++G P EE Sbjct: 204 YRAPEIMLSFQSYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQILHILGTPNEETL 263 Query: 244 PRDVALPRQAFHSK-----SAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHP 298 R + PR + + + +P + + DLL + L F+P+ RIS AL HP Sbjct: 264 SR-IGSPRAQEYVRNLPFMAKKPFPTLFPNANPDALDLLDRMLAFDPSSRISVEQALEHP 322 Query: 299 YFQ 301 Y Sbjct: 323 YLH 325 >4MYG-A nrPDB Length = 372 Score = 169 bits (428), Expect = 2e-42, Method: Compositional matrix adjust. Identities = 114/309 (36%), Positives = 161/309 (52%), Gaps = 16/309 (5%) Query: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 Y +G GAYG V A D K G VA+K++ E RE+ +L+H++ Sbjct: 45 YVSPTHVGSGAYGSVCSAID-KRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQ--- 100 Query: 73 HPNVVRLFDVCTVSRTDRE-TKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLR 131 H NV+ L DV T + + R LV + DL K+ E I+ +++Q+L+ Sbjct: 101 HENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDL----QKIMGMEFSEEKIQYLVYQMLK 156 Query: 132 GLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVL 191 GL ++HS VVHRDLKP N+ V ++K+ DFGLAR +M T VVT WYRAPEV+ Sbjct: 157 GLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEM--TGYVVTRWYRAPEVI 214 Query: 192 LQ-SSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALP 250 L Y VD+WSVGCI AEM K LF+G +DQL +IL V G+PG E + Sbjct: 215 LSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKA 274 Query: 251 RQAFHSKSAQPIEKFVTDI----DELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERC 306 +++ Q K T + DLL K L + KR++A AL+HP+F+ Sbjct: 275 AKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDP 334 Query: 307 KENLDSHLP 315 +E ++ P Sbjct: 335 EEETEAQQP 343 >1CM8-A nrPDB Length = 367 Score = 167 bits (424), Expect = 4e-42, Method: Compositional matrix adjust. Identities = 111/300 (37%), Positives = 164/300 (54%), Gaps = 21/300 (7%) Query: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 Y + +G GAYG V A D + G + VA+K++ E RE+ +L+H+ Sbjct: 27 YRDLQPVGSGAYGAVCSAVDGRTGAK-VAIKKLYRPFQSELFAKRAYRELRLLKHMR--- 82 Query: 73 HPNVVRLFDVCTVSRT-DRETKLTLVFEHVDQDLTTYL--DKVPEPGVPTETIKDMMFQL 129 H NV+ L DV T T D T LV + DL + +K+ E + I+ +++Q+ Sbjct: 83 HENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGE-----DRIQFLVYQM 137 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPE 189 L+GL ++H+ ++HRDLKP N+ V ++K+ DFGLAR +M T VVT WYRAPE Sbjct: 138 LKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEM--TGYVVTRWYRAPE 195 Query: 190 VLLQ-SSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA 248 V+L Y VD+WSVGCI AEM K LF+GS +DQL +I+ V G P E + + + Sbjct: 196 VILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAE-FVQRLQ 254 Query: 249 LPRQAFHSKSAQPIEK-----FVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDL 303 + K +EK +T+ L +LL K L + +R++A AL+HPYF+ L Sbjct: 255 SDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESL 314 >4EWQ-A nrPDB Length = 383 Score = 167 bits (423), Expect = 5e-42, Method: Compositional matrix adjust. Identities = 109/296 (36%), Positives = 161/296 (54%), Gaps = 15/296 (5%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 ++Y+ ++ +G GAYG V A D K G R VA+K++ T RE+ +L+H++ Sbjct: 45 ERYQNLSPVGSGAYGSVCAAFDTKTGLR-VAVKKLSRPFQSIIHAKRTYRELRLLKHMK- 102 Query: 71 FEHPNVVRLFDVCTVSRTDRE-TKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQL 129 H NV+ L DV T +R+ E + LV + DL + V + + ++ +++Q+ Sbjct: 103 --HENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLN---NIVKCQKLTDDHVQFLIYQI 157 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPE 189 LRGL ++HS ++HRDLKP N+ V ++K+ DFGLAR +M T V T WYRAPE Sbjct: 158 LRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEM--TGYVATRWYRAPE 215 Query: 190 VLLQ-SSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPR-DV 247 ++L Y VD+WSVGCI AE+ + LF G+ +DQL IL ++G PG E + Sbjct: 216 IMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISS 275 Query: 248 ALPRQAFHSKSAQPIEKFVT---DIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 R S + P F + L DLL K L + KRI+A AL+H YF Sbjct: 276 ESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF 331 >3PG1-A nrPDB Length = 362 Score = 166 bits (420), Expect = 1e-41, Method: Compositional matrix adjust. Identities = 113/300 (37%), Positives = 151/300 (50%), Gaps = 21/300 (7%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRV--RVQTGEEGMPLS-------TIREVAVLRHLE 69 I G+YG V D + G VA+KRV V G LS +RE+ +L H Sbjct: 30 ISSGSYGAVCAGVD--SEGIPVAIKRVFNTVSDGRTVNILSDSFLCKRVLREIRLLNH-- 85 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQL 129 F HPN++ L D+ KL LV E + DL + + + I+ M+ + Sbjct: 86 -FHHPNILGLRDIFVHFEEPAMHKLYLVTELMRTDLAQVIHD-QRIVISPQHIQYFMYHI 143 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPE 189 L GL LH VVHRDL P NIL+ + I + DF LAR + T V WYRAPE Sbjct: 144 LLGLHVLHEAGVVHRDLHPGNILLADNNDITICDFNLAREDTADANKTHYVTHRWYRAPE 203 Query: 190 VLLQ-SSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDW----- 243 +++Q + VD+WS GC+ AEMF RK LFRGS+ +QL KI++V+G P ED Sbjct: 204 LVMQFKGFTKLVDMWSAGCVMAEMFNRKALFRGSTFYNQLNKIVEVVGTPKIEDVVMFSS 263 Query: 244 PRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDL 303 P R + + A+ V D + DL+ K L FNP +RIS AL HPYF+ L Sbjct: 264 PSARDYLRNSLSNVPARAWTAVVPTADPVALDLIAKMLEFNPQRRISTEQALRHPYFESL 323 >4ZSG-A nrPDB Length = 347 Score = 166 bits (419), Expect = 2e-41, Method: Compositional matrix adjust. Identities = 107/300 (35%), Positives = 161/300 (53%), Gaps = 17/300 (5%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETF 71 +YE + IG GAYG V AR + G+ VA+K++ T+RE+ +L+H F Sbjct: 8 EYEIIETIGNGAYGVVSSARR-RLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKH---F 63 Query: 72 EHPNVVRLFDVCTVSRTDRETK-LTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130 +H N++ + D+ + E K + +V + ++ DL + +P + E ++ ++QLL Sbjct: 64 KHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHS-SQP-LTLEHVRYFLYQLL 121 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLAR-----IYSFQMALTSVVVTLWY 185 RGL ++HS +V+HRDLKP N+LV + ++K+ DFG+AR Q +T V T WY Sbjct: 122 RGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWY 181 Query: 186 RAPEVLLQ-SSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPG----E 240 RAPE++L Y +DLWSVGCIF EM R+ LF G + V QL I+ V+G P + Sbjct: 182 RAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQ 241 Query: 241 EDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 V Q+ + P E D LL + L F P+ RISA +AL HP+ Sbjct: 242 AVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFL 301 >3OZ6-A nrPDB Length = 388 Score = 165 bits (417), Expect = 2e-41, Method: Compositional matrix adjust. Identities = 114/337 (33%), Positives = 173/337 (51%), Gaps = 62/337 (18%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 ++YE V ++G+GAYG V+K+ D + G VA+K++ T RE+ +L L Sbjct: 9 RKYELVKKLGKGAYGIVWKSID-RRTGEVVAVKKIFDAFQNSTDAQRTFREIMILTELSG 67 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYL-DKVPEPGVPTETIKDMMFQL 129 H N+V L +V R D + + LVF++++ DL + + EP V + + ++QL Sbjct: 68 --HENIVNLLNVL---RADNDRDVYLVFDYMETDLHAVIRANILEP-VHKQYV---VYQL 118 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY------------------- 170 ++ + +LHS ++HRD+KP NIL+ + +K+ADFGL+R + Sbjct: 119 IKVIKYLHSGGLLHRDMKPSNILLNAECHVKVADFGLSRSFVNIRRVTNNIPLSINENTE 178 Query: 171 SF---QMALTSVVVTLWYRAPEVLLQSS-YATPVDLWSVGCIFAEMFRRKPLFRGSSDVD 226 +F Q LT V T WYRAPE+LL S+ Y +D+WS+GCI E+ KP+F GSS ++ Sbjct: 179 NFDDDQPILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGKPIFPGSSTMN 238 Query: 227 QLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFV-------------------- 266 QL +I+ VI P E DV + F + +++ V Sbjct: 239 QLERIIGVIDFPSNE----DVESIQSPFAKTMIESLKEKVEIRQSNKRDIFTKWKNLLLK 294 Query: 267 ----TDIDELGKDLLLKCLTFNPAKRISAYSALSHPY 299 D +E DLL K L FNP KRISA AL HP+ Sbjct: 295 INPKADCNEEALDLLDKLLQFNPNKRISANDALKHPF 331 >4IC8-A nrPDB Length = 442 Score = 165 bits (417), Expect = 3e-41, Method: Compositional matrix adjust. Identities = 107/300 (35%), Positives = 161/300 (53%), Gaps = 17/300 (5%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETF 71 +YE + IG GAYG V AR + G+ VA+K++ T+RE+ +L+H F Sbjct: 56 EYEIIETIGNGAYGVVSSARR-RLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKH---F 111 Query: 72 EHPNVVRLFDVCTVSRTDRETK-LTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130 +H N++ + D+ + E K + +V + ++ DL + +P + E ++ ++QLL Sbjct: 112 KHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSS-QP-LTLEHVRYFLYQLL 169 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLAR-----IYSFQMALTSVVVTLWY 185 RGL ++HS +V+HRDLKP N+LV + ++K+ DFG+AR Q +T V T WY Sbjct: 170 RGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWY 229 Query: 186 RAPEVLLQ-SSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPG----E 240 RAPE++L Y +DLWSVGCIF EM R+ LF G + V QL I+ V+G P + Sbjct: 230 RAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQ 289 Query: 241 EDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 V Q+ + P E D LL + L F P+ RISA +AL HP+ Sbjct: 290 AVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFL 349 >3NIE-A nrPDB Length = 429 Score = 162 bits (410), Expect = 2e-40, Method: Compositional matrix adjust. Identities = 121/360 (33%), Positives = 172/360 (47%), Gaps = 67/360 (18%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETF 71 YE IG G+YG V+ A D KN + VA+K+V + +RE+ +L L++ Sbjct: 29 NYEIKHLIGRGSYGYVYLAYD-KNANKNVAIKKVNRMFEDLIDCKRILREITILNRLKS- 86 Query: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLR 131 ++RL D+ + +L +V E D DL L K P + + +K +++ LL Sbjct: 87 --DYIIRLHDLIIPEDLLKFDELYIVLEIADSDLKK-LFKTP-IFLTEQHVKTILYNLLL 142 Query: 132 GLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYS-------------------- 171 G F+H ++HRDLKP N L+ +K+ DFGLAR + Sbjct: 143 GEKFIHESGIIHRDLKPANCLLNQDCSVKICDFGLARTINSDKDIHIVNDLEEKEENEEP 202 Query: 172 ------FQMALTSVVVTLWYRAPE-VLLQSSYATPVDLWSVGCIFAEMFR---------- 214 + LTS VVT WYRAPE +LLQ +Y +D+WS GCIFAE+ Sbjct: 203 GPHNKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDIWSTGCIFAELLNMMKSHINNPT 262 Query: 215 -RKPLFRGSS-----------------DVDQLGKILDVIGLPGEEDWP----RDVALPRQ 252 R PLF GSS + DQL I +VIG P EED ++V + Sbjct: 263 NRFPLFPGSSCFPLSPDHNSKKVHEKSNRDQLNIIFNVIGTPPEEDLKCITKQEVIKYIK 322 Query: 253 AFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDS 312 F ++ + K + I + G DLL L FN KRI+ ALSHPY +D+ KENL++ Sbjct: 323 LFPTRDGIDLSKKYSSISKEGIDLLESMLRFNAQKRITIDKALSHPYLKDVR--KENLEN 380 >4CRL-A nrPDB Length = 406 Score = 162 bits (409), Expect = 3e-40, Method: Compositional matrix adjust. Identities = 110/322 (34%), Positives = 171/322 (53%), Gaps = 49/322 (15%) Query: 17 AEIGEGAYGKVFKARDLKNGGRF-VALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPN 75 ++G G YG V+KA+ ALK++ G+ +S RE+A+LR L+ HPN Sbjct: 28 CKVGRGTYGHVYKAKRKDGKDDKDYALKQIE----GTGISMSACREIALLRELK---HPN 80 Query: 76 VVRLFDVCTVSRTDRETKLTLVFEHVDQDL--------TTYLDKVPEPGVPTETIKDMMF 127 V+ L V +S DR K+ L+F++ + DL + +K P +P +K +++ Sbjct: 81 VISLQKVF-LSHADR--KVWLLFDYAEHDLWHIIKFHRASKANKKPV-QLPRGMVKSLLY 136 Query: 128 QLLRGLDFLHSHRVVHRDLKPQNILVTSS----GQIKLADFGLARIYSFQMA----LTSV 179 Q+L G+ +LH++ V+HRDLKP NILV G++K+AD G AR+++ + L V Sbjct: 137 QILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPV 196 Query: 180 VVTLWYRAPEVLLQS-SYATPVDLWSVGCIFAEMFRRKPLFRGSSD---------VDQLG 229 VVT WYRAPE+LL + Y +D+W++GCIFAE+ +P+F + DQL Sbjct: 197 VVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLD 256 Query: 230 KILDVIGLPGEEDWPRDVALPRQAFHSKS-----------AQPIEKFVTDIDELGKDLLL 278 +I +V+G P ++DW +P + K + +EK D LL Sbjct: 257 RIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQ 316 Query: 279 KCLTFNPAKRISAYSALSHPYF 300 K LT +P KRI++ A+ PYF Sbjct: 317 KLLTMDPIKRITSEQAMQDPYF 338 >3GC9-A nrPDB Length = 370 Score = 160 bits (404), Expect = 8e-40, Method: Compositional matrix adjust. Identities = 105/297 (35%), Positives = 168/297 (56%), Gaps = 17/297 (5%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 Q+ + + +G GAYG V A D + + VA+K++ T RE+ +L+HL+ Sbjct: 28 QRLQGLRPVGSGAYGSVCSAYDARLRQK-VAVKKLSRPFQSLIHARRTYRELRLLKHLK- 85 Query: 71 FEHPNVVRLFDVCTVSRTDRE-TKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQL 129 H NV+ L DV T + + + +++ LV + DL + V + E ++ +++QL Sbjct: 86 --HENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLN---NIVKSQALSDEHVQFLVYQL 140 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPE 189 LRGL ++HS ++HRDLKP N+ V ++++ DFGLAR +M T V T WYRAPE Sbjct: 141 LRGLKYIHSAGIIHRDLKPSNVAVNEDSELRILDFGLARQADEEM--TGYVATRWYRAPE 198 Query: 190 VLLQ-SSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA 248 ++L Y VD+WSVGCI AE+ + K LF GS +DQL +I++V+G P E + ++ Sbjct: 199 IMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAK-IS 257 Query: 249 LPRQAFHSKSAQPI-EKFVTDI----DELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 + +S P+ +K ++ I + L DLL + L + +R+SA AL+H YF Sbjct: 258 SEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYF 314 >3OHT-A nrPDB Length = 389 Score = 160 bits (404), Expect = 9e-40, Method: Compositional matrix adjust. Identities = 101/296 (34%), Positives = 165/296 (55%), Gaps = 15/296 (5%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 ++Y+ ++ +G GAYG V + D+K+G + +A+K++ T RE+ +L+H++ Sbjct: 51 ERYQTLSPVGSGAYGSVCSSYDVKSGLK-IAVKKLSRPFQSIIHAKRTYRELRLLKHMK- 108 Query: 71 FEHPNVVRLFDVCTVSRTDRE-TKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQL 129 H NV+ L DV T + + E + LV + DL + V + + ++ +++Q+ Sbjct: 109 --HENVIGLLDVFTPATSLEEFNDVYLVTHLMGADLN---NIVKCQKLTDDHVQFLIYQI 163 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPE 189 LRGL ++HS ++HRDLKP N+ V ++K+ DFGLAR +M T V T WYRAPE Sbjct: 164 LRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEM--TGYVATRWYRAPE 221 Query: 190 VLLQ-SSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA 248 ++L Y VD+WSVGCI AE+ + LF G+ ++QL +I+ + G P R + Sbjct: 222 IMLNWMHYNMTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPASVISRMPS 281 Query: 249 LPRQAFHSKSAQPIEKFVTDI----DELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 + + + Q ++ D+ + L DLL K L + KRI+A AL+HPYF Sbjct: 282 HEARNYINSLPQMPKRNFADVFIGANPLAVDLLEKMLVLDTDKRITASEALAHPYF 337 >2I6L-A nrPDB Length = 320 Score = 158 bits (400), Expect = 3e-39, Method: Compositional matrix adjust. Identities = 106/307 (34%), Positives = 173/307 (56%), Gaps = 27/307 (8%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETF 71 +Y + +G G G VF A D + + VA+K++ V T + + +RE+ ++R L+ Sbjct: 12 RYMDLKPLGCGGNGLVFSAVD-NDCDKRVAIKKI-VLTDPQSVK-HALREIKIIRRLD-- 66 Query: 72 EHPNVVRLFDVCTVSR---TDRETKLT------LVFEHVDQDLTTYLDKVPEPGVPTETI 122 H N+V++F++ S TD LT +V E+++ DL L++ P + E Sbjct: 67 -HDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGP---LLEEHA 122 Query: 123 KDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQI-KLADFGLARI----YSFQMALT 177 + M+QLLRGL ++HS V+HRDLKP N+ + + + K+ DFGLARI YS + L+ Sbjct: 123 RLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLS 182 Query: 178 SVVVTLWYRAPEVLLQ-SSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIG 236 +VT WYR+P +LL ++Y +D+W+ GCIFAEM K LF G+ +++Q+ IL+ I Sbjct: 183 EGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIP 242 Query: 237 LPGEEDWPRDVALPRQAFH---SKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYS 293 + EED +++ ++ +P+ + + I D L + LTF+P R++A Sbjct: 243 VVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREAVDFLEQILTFSPMDRLTAEE 302 Query: 294 ALSHPYF 300 ALSHPY Sbjct: 303 ALSHPYM 309 >3N9X-A nrPDB Length = 432 Score = 158 bits (399), Expect = 4e-39, Method: Compositional matrix adjust. Identities = 116/346 (33%), Positives = 167/346 (48%), Gaps = 64/346 (18%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVR 78 IG G+YG V+ A D KN + VA+K+V + +RE+ +L L++ ++R Sbjct: 34 IGRGSYGYVYLAYD-KNTEKNVAIKKVNRMFEDLIDCKRILREITILNRLKS---DYIIR 89 Query: 79 LFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHS 138 L+D+ + +L +V E D DL L K P + E IK +++ LL G +F+H Sbjct: 90 LYDLIIPDDLLKFDELYIVLEIADSDLKK-LFKTP-IFLTEEHIKTILYNLLLGENFIHE 147 Query: 139 HRVVHRDLKPQNILVTSSGQIKLADFGLARIY-----------------------SFQMA 175 ++HRDLKP N L+ +K+ DFGLAR + + Sbjct: 148 SGIIHRDLKPANCLLNQDCSVKVCDFGLARTINSEKDTNIVNDLEENEEPGPHNKNLKKQ 207 Query: 176 LTSVVVTLWYRAPE-VLLQSSYATPVDLWSVGCIFAEMF-----------RRKPLFRGS- 222 LTS VVT WYRAPE +LLQ +Y +D+WS GCIFAE+ R PLF GS Sbjct: 208 LTSHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAELLNMLQSHINDPTNRFPLFPGSS 267 Query: 223 ----------------SDVDQLGKILDVIGLPGEEDW-----PRDVALPRQAFHSKSAQP 261 S+ DQL I ++IG P E+D P + + H K Sbjct: 268 CFPLSPDRNSKKVHEKSNRDQLNIIFNIIGTPTEDDLKNINKPEVIKYIKLFPHRKPINL 327 Query: 262 IEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCK 307 +K+ + I + G +LL L FNP KRI+ AL HPY +D+ + K Sbjct: 328 KQKYPS-ISDDGINLLESMLKFNPNKRITIDQALDHPYLKDVRKKK 372 >3FI2-A nrPDB Length = 353 Score = 156 bits (394), Expect = 1e-38, Method: Compositional matrix adjust. Identities = 105/307 (34%), Positives = 154/307 (50%), Gaps = 24/307 (7%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 ++Y+ + IG GA G V A D R VA+K++ + RE+ +++ Sbjct: 24 KRYQNLKPIGSGAQGIVCAAYD-AVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMK---C 79 Query: 71 FEHPNVVRLFDVCTVSRTDRETK-LTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQL 129 H N++ L +V T +T E + + LV E +D +L +V + + E + +++Q+ Sbjct: 80 VNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLC----QVIQMELDHERMSYLLYQM 135 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPE 189 L G+ LHS ++HRDLKP NI+V S +K+ DFGLAR +T VVT +YRAPE Sbjct: 136 LCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPE 195 Query: 190 VLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGE--------- 240 V+L Y VD+WSVGCI EM R K LF G +DQ K+++ +G P Sbjct: 196 VILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPT 255 Query: 241 -----EDWPRDVALPRQAFHSKSAQPIEKFVTDID-ELGKDLLLKCLTFNPAKRISAYSA 294 E+ P+ L S P + + +DLL K L +PAKRIS A Sbjct: 256 VRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDA 315 Query: 295 LSHPYFQ 301 L HPY Sbjct: 316 LQHPYIN 322 >1JNK-A nrPDB Length = 423 Score = 156 bits (394), Expect = 1e-38, Method: Compositional matrix adjust. Identities = 105/307 (34%), Positives = 154/307 (50%), Gaps = 24/307 (7%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 ++Y+ + IG GA G V A D R VA+K++ + RE+ +++ Sbjct: 62 KRYQNLKPIGSGAQGIVCAAYDAV-LDRNVAIKKLSRPFQNQTHAKRAYRELVLMK---C 117 Query: 71 FEHPNVVRLFDVCTVSRTDRETK-LTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQL 129 H N++ L +V T +T E + + LV E +D +L +V + + E + +++Q+ Sbjct: 118 VNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLC----QVIQMELDHERMSYLLYQM 173 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPE 189 L G+ LHS ++HRDLKP NI+V S +K+ DFGLAR +T VVT +YRAPE Sbjct: 174 LCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPE 233 Query: 190 VLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGE--------- 240 V+L Y VD+WSVGCI EM R K LF G +DQ K+++ +G P Sbjct: 234 VILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPT 293 Query: 241 -----EDWPRDVALPRQAFHSKSAQPIEKFVTDID-ELGKDLLLKCLTFNPAKRISAYSA 294 E+ P+ L S P + + +DLL K L +PAKRIS A Sbjct: 294 VRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDA 353 Query: 295 LSHPYFQ 301 L HPY Sbjct: 354 LQHPYIN 360 >3E7O-A nrPDB Length = 360 Score = 153 bits (386), Expect = 1e-37, Method: Compositional matrix adjust. Identities = 104/306 (33%), Positives = 157/306 (51%), Gaps = 24/306 (7%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 ++Y+ + IG GA G V A D G VA+K++ + RE+ +L+ Sbjct: 22 KRYQQLKPIGSGAQGIVCAAFDTVLGIN-VAVKKLSRPFQNQTHAKRAYRELVLLK---C 77 Query: 71 FEHPNVVRLFDVCTVSRTDRETK-LTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQL 129 H N++ L +V T +T E + + LV E +D +L +V + E + +++Q+ Sbjct: 78 VNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLC----QVIHMELDHERMSYLLYQM 133 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPE 189 L G+ LHS ++HRDLKP NI+V S +K+ DFGLAR S +T VVT +YRAPE Sbjct: 134 LCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTASTNFMMTPYVVTRYYRAPE 193 Query: 190 VLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVAL 249 V+L Y VD+WSVGCI E+ + +F+G+ +DQ K+++ +G P E Sbjct: 194 VILGMGYKENVDIWSVGCIMGELVKGSVIFQGTDHIDQWNKVIEQLGTPSAEFMAALQPT 253 Query: 250 PRQAFHSKSAQP---IEKFVTDI--------DEL----GKDLLLKCLTFNPAKRISAYSA 294 R ++ A P E+ D D++ +DLL K L +P KRIS A Sbjct: 254 VRNYVENRPAYPGIAFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEA 313 Query: 295 LSHPYF 300 L HPY Sbjct: 314 LRHPYI 319 >4O2Z-A nrPDB Length = 377 Score = 152 bits (385), Expect = 1e-37, Method: Compositional matrix adjust. Identities = 104/306 (33%), Positives = 163/306 (53%), Gaps = 26/306 (8%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVR--VQTGEEGMPLSTIREVAVLRHL 68 +Y + +G GAYG D G + V++K+ R + E+G +RE+ ++R Sbjct: 45 SKYTLLKILGMGAYGIACSCLDGDTGEK-VSIKKCRDVFRDVEDGK--RVLREIDMMRF- 100 Query: 69 ETFEHPNVVRLFDVCTVSRTDRET--KLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMM 126 F H N++ + ++ + + + + +V +D D+ L + ++ + Sbjct: 101 --FHHENLLNVVNILPPLKREYHSFEDVYVVTPLMDVDMNVVLRS--RQVLEESHMQYFV 156 Query: 127 FQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMA-LTSVVVTLWY 185 +Q+LRGL +LHS V HRDLKP N++ S ++K+ DFGL+R + LT V+T WY Sbjct: 157 YQILRGLKYLHSANVAHRDLKPANLVTNISCELKIIDFGLSRSVDVPYSELTDYVITRWY 216 Query: 186 RAPEVLLQSS-YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWP 244 R PE+LL+++ Y+T VD+WSVGCIFAEM+ RKP+F G + +DQL I IG P P Sbjct: 217 RPPELLLENTNYSTAVDIWSVGCIFAEMYNRKPVFPGRNTMDQLRMIAQHIGKP-----P 271 Query: 245 RDVALPRQAFHSKSAQP-----IEKFVTDI--DELGKDLLLKCLTFNPAKRISAYSALSH 297 + R+A + P I K V + + G D L K T +P+KR +A L+H Sbjct: 272 ASIVEHREALEKLNELPDGSLNIPKLVPGLAGNTEGIDFLSKMWTLDPSKRPTAADMLAH 331 Query: 298 PYFQDL 303 PY L Sbjct: 332 PYLAHL 337 >4E7W-A nrPDB Length = 394 Score = 147 bits (370), Expect = 7e-36, Method: Compositional matrix adjust. Identities = 106/318 (33%), Positives = 167/318 (52%), Gaps = 24/318 (7%) Query: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 Y IG G++G VF+A+ +++ VA+K+V + RE+ ++R + Sbjct: 42 YTNCKVIGNGSFGVVFQAKLVESDE--VAIKKVLQDKRFKN------RELQIMR---IVK 90 Query: 73 HPNVVRL--FDVCTVSRTDRETKLTLVFEHVDQDL---TTYLDKVPEPGVPTETIKDMMF 127 HPNVV L F + D E L LV E+V + + + + K+ + +P IK M+ Sbjct: 91 HPNVVDLKAFFYSNGDKKD-EVFLNLVLEYVPETVYRASRHYAKLKQ-TMPMLLIKLYMY 148 Query: 128 QLLRGLDFLHSHRVVHRDLKPQNILV-TSSGQIKLADFGLARIYSFQMALTSVVVTLWYR 186 QLLR L ++HS + HRD+KPQN+L+ SG +KL DFG A+I S + + +YR Sbjct: 149 QLLRSLAYIHSIGICHRDIKPQNLLLDPPSGVLKLIDFGSAKILIAGEPNVSYICSRYYR 208 Query: 187 APEVLL-QSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPR 245 APE++ ++Y T +D+WS GC+ AE+ + +PLF G S +DQL +I+ V+G P E Sbjct: 209 APELIFGATNYTTNIDIWSTGCVMAELMQGQPLFPGESGIDQLVEIIKVLGTPSREQIKT 268 Query: 246 -DVALPRQAFHSKSAQPIEK-FVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDL 303 + F P K F DL+ + L + P+ R++A AL HP+F +L Sbjct: 269 MNPNYMEHKFPQIRPHPFSKVFRPRTPPDAIDLISRLLEYTPSARLTAIEALCHPFFDEL 328 Query: 304 ERCKENLDS--HLPPSQN 319 + + + LPP N Sbjct: 329 RTGEARMPNGRELPPLFN 346 >3RP9-A nrPDB Length = 458 Score = 146 bits (368), Expect = 1e-35, Method: Compositional matrix adjust. Identities = 112/358 (31%), Positives = 165/358 (46%), Gaps = 74/358 (20%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTI-REVAVLRHLET 70 +YE IG G+YG V +A D K R VA+K++ ++ E+ + I RE+A+L L Sbjct: 54 RYEIRHLIGTGSYGHVCEAYD-KLEKRVVAIKKI-LRVFEDLIDCKRILREIAILNRLN- 110 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTET-IKDMMFQL 129 H +VV++ D+ ++ +L +V E D D P TE IK +++ L Sbjct: 111 --HDHVVKVLDIVIPKDVEKFDELYVVLEIADSDFKKLFRT---PVYLTELHIKTLLYNL 165 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSF----------------- 172 L G+ ++HS ++HRDLKP N LV +K+ DFGLAR + Sbjct: 166 LVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFGLARTVDYPENGNSQLPISPREDDM 225 Query: 173 -----------QMALTSVVVTLWYRAPE-VLLQSSYATPVDLWSVGCIFAEMFR------ 214 + LT VVT WYRAPE +LLQ +Y +D+WS+GCIFAE+ Sbjct: 226 NLVTFPHTKNLKRQLTGHVVTRWYRAPELILLQENYTEAIDVWSIGCIFAELLNMIKENV 285 Query: 215 -----RKPLFRGSS--------------------DVDQLGKILDVIGLPGEEDW----PR 245 R PLF GSS + DQL I +++G P EED Sbjct: 286 AYHADRGPLFPGSSCFPLSPDQKAGNDFKFHTRGNRDQLNVIFNILGTPSEEDIEALEKE 345 Query: 246 DVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDL 303 D + F + + + LL + L FNP KRI+ L+HP+F+++ Sbjct: 346 DAKRYIRIFPKREGTDLAERFPASSADAIHLLKRMLVFNPNKRITINECLAHPFFKEV 403 >3E3P-A nrPDB Length = 360 Score = 145 bits (367), Expect = 2e-35, Method: Compositional matrix adjust. Identities = 108/305 (35%), Positives = 157/305 (51%), Gaps = 36/305 (11%) Query: 20 GEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRL 79 G+G +G V ++ K+ G VA+K+V +Q P RE+ +++ L HPN+V+L Sbjct: 32 GQGTFGTVQLGKE-KSTGMSVAIKKV-IQD-----PRFRNRELQIMQDLAVLHHPNIVQL 84 Query: 80 --FDVCTVSRTDRETKLTLVFEHVDQDL-----TTYLDKVPEPGVPTETIKDMMFQLLRG 132 + R R+ L +V E+V L Y +V P + IK +FQL+R Sbjct: 85 QSYFYTLGERDRRDIYLNVVMEYVPDTLHRCCRNYYRRQVAPPPI---LIKVFLFQLIRS 141 Query: 133 LDFLH--SHRVVHRDLKPQNILVTSS-GQIKLADFGLARIYSFQMALTSVVVTLWYRAPE 189 + LH S V HRD+KP N+LV + G +KL DFG A+ S + + + +YRAPE Sbjct: 142 IGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKLSPSEPNVAYICSRYYRAPE 201 Query: 190 VLL-QSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPR--- 245 ++ Y T VD+WSVGCIFAEM +P+FRG + QL +I+ V+G P E + Sbjct: 202 LIFGNQHYTTAVDIWSVGCIFAEMMLGEPIFRGDNSAGQLHEIVRVLGCPSREVLRKLNP 261 Query: 246 ---DVALPRQAFHSKSAQPIEKF----VTDIDELGKDLLLKCLTFNPAKRISAYSALSHP 298 DV L ++SK F + D E DLL L + P +R+ Y AL HP Sbjct: 262 SHTDVDL----YNSKGIPWSNVFSDHSLKDAKE-AYDLLSALLQYLPEERMKPYEALCHP 316 Query: 299 YFQDL 303 YF +L Sbjct: 317 YFDEL 321 >2XS0-A nrPDB Length = 386 Score = 145 bits (367), Expect = 2e-35, Method: Compositional matrix adjust. Identities = 98/307 (31%), Positives = 153/307 (49%), Gaps = 24/307 (7%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 ++Y+ + IG GA G V A D R VA+K++ + RE+ +++ Sbjct: 26 KRYQNLKPIGSGAQGIVCAAYD-AILERNVAIKKLSRPFQNQTHAKRAYRELVLMK---C 81 Query: 71 FEHPNVVRLFDVCTVSRTDRETK-LTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQL 129 H N++ L +V T ++ E + + +V E +D +L +V + + E + +++Q+ Sbjct: 82 VNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLC----QVIQMELDHERMSYLLYQM 137 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPE 189 L G+ LHS ++HRDLKP NI+V S +K+ DFGLAR + VVT +YRAPE Sbjct: 138 LCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMVPFVVTRYYRAPE 197 Query: 190 VLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVAL 249 V+L Y VD+WSVGCI EM + LF G+ +DQ K+++ +G P E + Sbjct: 198 VILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQPT 257 Query: 250 PRQAFHSK---SAQPIEKFVTDI------------DELGKDLLLKCLTFNPAKRISAYSA 294 R ++ + EK D+ +DLL K L + +KRIS A Sbjct: 258 VRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEA 317 Query: 295 LSHPYFQ 301 L HPY Sbjct: 318 LQHPYIN 324 >3EB0-A nrPDB Length = 383 Score = 145 bits (366), Expect = 2e-35, Method: Compositional matrix adjust. Identities = 100/344 (29%), Positives = 165/344 (47%), Gaps = 49/344 (14%) Query: 5 GLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAV 64 GL + ++Y +G G++G V + D+++G RF ALK+V P RE+ + Sbjct: 1 GLETSSKKYSLGKTLGTGSFGIVCEVFDIESGKRF-ALKKVLQD------PRYKNRELDI 53 Query: 65 LRHLETFEHPNVVRLFDV---------------------------------CTVSRTDRE 91 ++ L+ H N+++L D + + Sbjct: 54 MKVLD---HVNIIKLVDYFYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQN 110 Query: 92 TKLTLVFEHVDQDLTTYLDKVPEPG--VPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQ 149 L ++ E+V L L G +P I ++QL R + F+HS + HRD+KPQ Sbjct: 111 KYLNVIMEYVPDTLHKVLKSFIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQ 170 Query: 150 NILVTSS-GQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATP-VDLWSVGC 207 N+LV S +KL DFG A+ + + + +YRAPE++L ++ TP +DLWS+GC Sbjct: 171 NLLVNSKDNTLKLCDFGSAKKLIPSEPSVAYICSRFYRAPELMLGATEYTPSIDLWSIGC 230 Query: 208 IFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPR-DVALPRQAFHSKSAQPIEKFV 266 +F E+ KPLF G + +DQL +I+ ++G P +E R + F + A+ K + Sbjct: 231 VFGELILGKPLFSGETSIDQLVRIIQIMGTPTKEQMIRMNPHYTEVRFPTLKAKDWRKIL 290 Query: 267 TD-IDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKEN 309 + L DLL + L + P RI+ Y A++HP+F L E+ Sbjct: 291 PEGTPSLAIDLLEQILRYEPDLRINPYEAMAHPFFDHLRNSYES 334 >5AWM-A nrPDB Length = 394 Score = 140 bits (354), Expect = 6e-34, Method: Compositional matrix adjust. Identities = 100/311 (32%), Positives = 150/311 (48%), Gaps = 33/311 (10%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETF 71 +Y + IG GA G V A D + VA+K++ RE +++ Sbjct: 45 RYINLRPIGSGAQGIVCAAYDTITQ-QNVAIKKLSRPFQNVTHAKRAYREFKLMK---LV 100 Query: 72 EHPNVVRLFDVCTVSRTDRETK-LTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130 H N++ L + T R E + + LV E +D +L +V + + + + +++Q+L Sbjct: 101 NHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLC----QVIQMDLDHDRMSYLLYQML 156 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEV 190 G+ LHS ++HRDLKP NI+V + +K+ DFGLAR +T VVT +YRAPEV Sbjct: 157 CGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEV 216 Query: 191 LLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGE---------- 240 +L Y VD+WSVGCI EM R LF G+ +DQ KI++ +G P Sbjct: 217 ILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTV 276 Query: 241 ----EDWPR------DVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRIS 290 E+ PR D P F + + Q + +D ++LL K L +P +RIS Sbjct: 277 RNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASD----ARNLLSKMLVIDPEQRIS 332 Query: 291 AYSALSHPYFQ 301 AL H Y Sbjct: 333 VDEALKHEYIN 343 >5ZTN-A nrPDB Length = 429 Score = 133 bits (335), Expect = 1e-31, Method: Compositional matrix adjust. Identities = 95/326 (29%), Positives = 155/326 (47%), Gaps = 46/326 (14%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETF 71 +YE + IG+G++G+V KA D K + VALK VR E+ E+ +L HL Sbjct: 98 RYEVLKVIGKGSFGQVVKAYDHKVH-QHVALKMVR---NEKRFHRQAAEEIRILEHLRKQ 153 Query: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLR 131 + N + + + + + + FE + +L + K G ++ +L+ Sbjct: 154 DKDNTMNVIHM--LENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQ 211 Query: 132 GLDFLHSHRVVHRDLKPQNILVTSSGQ--IKLADFGLARIYSFQMALTSVVVTLWYRAPE 189 LD LH +R++H DLKP+NIL+ G+ IK+ DFG + Y Q T + + +YRAPE Sbjct: 212 CLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFG-SSCYEHQRVYT-YIQSRFYRAPE 269 Query: 190 VLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVAL 249 V+L + Y P+D+WS+GCI AE+ PL G + DQL +++++G+P ++ D + Sbjct: 270 VILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLL--DASK 327 Query: 250 PRQAFHSKSAQPIEKFVTDI----------------------------------DELGKD 275 + F S P VT + D L D Sbjct: 328 RAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLD 387 Query: 276 LLLKCLTFNPAKRISAYSALSHPYFQ 301 L +CL ++PA R++ AL HP+ + Sbjct: 388 FLKQCLEWDPAVRMTPGQALRHPWLR 413 >5Y86-A nrPDB Length = 588 Score = 132 bits (331), Expect = 3e-31, Method: Compositional matrix adjust. Identities = 95/326 (29%), Positives = 163/326 (50%), Gaps = 48/326 (14%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETF 71 +YE + IG+G++G+V + D K ++VALK VR E+ E+ +L HL+ Sbjct: 208 RYEVLKIIGKGSFGQVARVYDHKLR-QYVALKMVR---NEKRFHRQAAEEIRILEHLKKQ 263 Query: 72 EHP---NVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQ 128 + NV+ + + T + + FE + DL + K G + ++ Sbjct: 264 DKTGSMNVIHMLESFTF-----RNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQS 318 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQ--IKLADFGLARIYSFQMALTSVVVTLWYR 186 +L+ LD LH ++++H DLKP+NIL+ G+ K+ DFG + + +Q L + + + +YR Sbjct: 319 ILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG-SSCFEYQ-KLYTYIQSRFYR 376 Query: 187 APEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLP-------- 238 APE++L S Y+TP+D+WS GCI AE+ +PLF G + DQL +++++G+P Sbjct: 377 APEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQS 436 Query: 239 -------GEEDWPRDVALPRQA------------FHSKSAQPIEK-FVTDI----DELGK 274 + PR ++ QA K P K + T + D L Sbjct: 437 KRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFI 496 Query: 275 DLLLKCLTFNPAKRISAYSALSHPYF 300 + L +CL ++P+ R++ AL HP+ Sbjct: 497 EFLKRCLHWDPSARLTPAQALRHPWI 522 >5X8I-B nrPDB Length = 346 Score = 130 bits (327), Expect = 7e-31, Method: Compositional matrix adjust. Identities = 105/335 (31%), Positives = 166/335 (49%), Gaps = 53/335 (15%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETF 71 +YE V +GEGA+GKV + D K GGR VA+K V+ + + E+ VL HL T Sbjct: 14 RYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVK---NVDRYCEAARSEIQVLEHLNTT 70 Query: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPG-VP--TETIKDMMFQ 128 + + R V + + + +VFE + L+TY D + E G +P + I+ M +Q Sbjct: 71 DPNSTFRC--VQMLEWFEHHGHICIVFELLG--LSTY-DFIKENGFLPFRLDHIRKMAYQ 125 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSG-------------------QIKLADFGLARI 169 + + ++FLHS+++ H DLKP+NIL S IK+ DFG A Sbjct: 126 ICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSA-T 184 Query: 170 YSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLG 229 Y + +++V T YRAPEV+L ++ P D+WS+GCI E + +F + L Sbjct: 185 YDDEHH-STLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLA 243 Query: 230 KILDVIG-LPGEE---------------DWPRDVALPRQAFHSKSAQPIEKFVTDID--- 270 + ++G LP DW + R S++ +P+++F+ D Sbjct: 244 MMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYV--SRACKPLKEFMLSQDVEH 301 Query: 271 ELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLER 305 E DL+ K L ++PAKRI+ AL HP+F L++ Sbjct: 302 ERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKK 336 >5AIR-A nrPDB Length = 430 Score = 128 bits (321), Expect = 4e-30, Method: Compositional matrix adjust. Identities = 91/294 (30%), Positives = 151/294 (51%), Gaps = 21/294 (7%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVR 78 IG G++G V++A+ L + G VA+K+V + RE+ ++R L+ H N+VR Sbjct: 72 IGNGSFGVVYQAK-LCDSGELVAIKKVLQDKRFKN------RELQIMRKLD---HCNIVR 121 Query: 79 L--FDVCTVSRTDRETKLTLVFEHVDQDL---TTYLDKVPEPGVPTETIKDMMFQLLRGL 133 L F + + D E L LV ++V + + + + + +P +K M+QL R L Sbjct: 122 LRYFFYSSGEKKD-EVYLNLVLDYVPETVYRVARHYSRAKQ-TLPVIYVKLYMYQLFRSL 179 Query: 134 DFLHSHRVVHRDLKPQNILV-TSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLL 192 ++HS + HRD+KPQN+L+ + +KL DFG A+ S + + +YRAPE++ Sbjct: 180 AYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIF 239 Query: 193 QSS-YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPR-DVALP 250 ++ Y + +D+WS GC+ AE+ +P+F G S VDQL +I+ V+G P E + Sbjct: 240 GATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYT 299 Query: 251 RQAFHSKSAQPIEK-FVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDL 303 F A P K F L + L + P R++ A +H +F +L Sbjct: 300 EFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDEL 353 >4LFI-A nrPDB Length = 374 Score = 128 bits (321), Expect = 4e-30, Method: Compositional matrix adjust. Identities = 80/245 (32%), Positives = 136/245 (55%), Gaps = 28/245 (11%) Query: 73 HPNVVRLFDVCT--VSRTDRETKLTLVFEHVDQDLTTYLD-KVPEPGVPTETIKDMMFQL 129 H N++ LFD+ +S+T LVFE+VD +D ++ P + I+ MF+L Sbjct: 132 HANIIHLFDIIKDPISKTP-----ALVFEYVDN-----VDFRILYPKLTDLEIRFYMFEL 181 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVT-SSGQIKLADFGLARIYSFQMALTSVVVTLWYRAP 188 L+ LD+ HS ++HRD+KP N+++ + +++L D+GLA Y M V + +++ P Sbjct: 182 LKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGP 241 Query: 189 EVLLQSS-YATPVDLWSVGCIFAEM-FRRKPLFRGSSDVDQLGKILDVIGLPGEEDW--P 244 E+L+ Y +DLWS G + A M F+R+P F G+S+ DQL KI+ V+G E + Sbjct: 242 ELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLK 301 Query: 245 RDVALPRQAFHSKSA--QPIEKFVTD-------IDELGKDLLLKCLTFNPAKRISAYSAL 295 ++ LPR+ + +P +F+ D DE+ DL+ L ++ +R++A A+ Sbjct: 302 YEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEI-IDLIDNLLRYDHQERLTAKEAM 360 Query: 296 SHPYF 300 HP+F Sbjct: 361 GHPWF 365 >2PVN-A nrPDB Length = 352 Score = 126 bits (317), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 88/310 (28%), Positives = 155/310 (50%), Gaps = 29/310 (9%) Query: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 YE V ++G G Y +VF+ ++ N + + V+ + + ++ + Sbjct: 54 YEVVRKVGRGKYSEVFEGINVNNNEKCIIKILKPVKKKKIKREIKILQNLC--------G 105 Query: 73 HPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRG 132 PN+V+L D+ R +L+FE+V+ T + KV P + I+ +++LL+ Sbjct: 106 GPNIVKLLDIV---RDQHSKTPSLIFEYVNN--TDF--KVLYPTLTDYDIRYYIYELLKA 158 Query: 133 LDFLHSHRVVHRDLKPQNILVTSS-GQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVL 191 LD+ HS ++HRD+KP N+++ +++L D+GLA Y V + +++ PE+L Sbjct: 159 LDYCHSQGIMHRDVKPHNVMIDHELRKLRLIDWGLAEFYHPGKEYNVRVASRYFKGPELL 218 Query: 192 LQ-SSYATPVDLWSVGCIFAEM-FRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVAL 249 + Y +D+WS+GC+FA M FR++P F G + DQL KI V+G G + + Sbjct: 219 VDLQDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKIAKVLGTDGLNAYLNKYRI 278 Query: 250 P-----RQAFHSKSAQPIEKFVTDIDEL-----GKDLLLKCLTFNPAKRISAYSALSHPY 299 S +P KF+ ++ D L K L ++ +R++A A++HPY Sbjct: 279 ELDPQLEALVGRHSRKPWLKFMNADNQHLVSPEAIDFLDKLLRYDHQERLTALEAMTHPY 338 Query: 300 FQDLERCKEN 309 FQ + R EN Sbjct: 339 FQQV-RAAEN 347 >5UNP-A nrPDB Length = 369 Score = 122 bits (305), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 94/336 (27%), Positives = 158/336 (47%), Gaps = 57/336 (16%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVR-VQTGEEGMPLSTIREVAVLRHLE 69 ++YE V+ +GEG +G+V + D + GG VALK ++ V+ +E L E+ VL + Sbjct: 34 ERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARL----EINVLEKIN 89 Query: 70 TFEHPN---VVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMM 126 + N V++FD D + + FE + +L P ++ M Sbjct: 90 EKDPDNKNLCVQMFDW-----FDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMA 144 Query: 127 FQLLRGLDFLHSHRVVHRDLKPQNILVTSSG-------------------QIKLADFGLA 167 FQL + + FLH +++ H DLKP+NIL +S +++ DFG A Sbjct: 145 FQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSA 204 Query: 168 RIYSFQMALTSVVV-TLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVD 226 +F S +V T YRAPEV+L+ ++ P D+WS+GCI E + LF+ + + Sbjct: 205 ---TFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNRE 261 Query: 227 QLGKILDVIG-LP---------------GEEDWPRDVALPRQAFHSKSAQPIEKFVTDID 270 L + ++G +P G DW + + R + ++ +P+ +++T Sbjct: 262 HLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGR--YVRENCKPLRRYLTSEA 319 Query: 271 ELGK---DLLLKCLTFNPAKRISAYSALSHPYFQDL 303 E DL+ L + PAKR++ AL HP+F L Sbjct: 320 EEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARL 355 >5XVU-A nrPDB Length = 332 Score = 120 bits (300), Expect = 9e-28, Method: Compositional matrix adjust. Identities = 87/309 (28%), Positives = 157/309 (50%), Gaps = 34/309 (11%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 +YE + +IG G Y +VF D + + ++ + RE+ +L++L Sbjct: 31 NRYEIMKKIGRGKYSEVFNGYDTECN------RPCAIKVLKPVKKKKIKREIKILQNLNG 84 Query: 71 FEHPNVVRLFDVCT--VSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMF 127 PN+++L D+ V++T +L+FE+++ D T P + I+ ++ Sbjct: 85 --GPNIIKLLDIVKDPVTKTP-----SLIFEYINNIDFKTLY-----PKFTDKDIRYYIY 132 Query: 128 QLLRGLDFLHSHRVVHRDLKPQNILVTSSG-QIKLADFGLARIYSFQMALTSVVVTLWYR 186 Q+L+ LD+ HS ++HRD+KP NI++ QI+L +GLA Y V + +Y+ Sbjct: 133 QILKALDYCHSQGIMHRDVKPHNIMIDHENRQIRLISWGLAEFYHPGQEYNVRVASRYYK 192 Query: 187 APEVLLQ-SSYATPVDLWSVGCIFAEM-FRRKPLFRGSSDVDQLGKILDVIGLPGEEDWP 244 PE+L+ Y +D+WS+GC+ A M F+++P F G + DQL KI V+G + Sbjct: 193 GPELLIDLQLYDYSLDIWSLGCMLAGMIFKKEPFFCGHDNYDQLVKIAKVLGTEDLHAYL 252 Query: 245 RDVALPRQAFH-----SKSAQPIEKFVTDID-ELGK----DLLLKCLTFNPAKRISAYSA 294 + + + + +P F+T + ++ K DL+ K L ++ AKRI+ A Sbjct: 253 KKYNIKLKPHYLNILGEYERKPWSHFLTQSNIDIAKDEVIDLIDKMLIYDHAKRIAPKEA 312 Query: 295 LSHPYFQDL 303 + HPYF+++ Sbjct: 313 MEHPYFREV 321 >3RAW-A nrPDB Length = 381 Score = 119 bits (298), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 97/348 (27%), Positives = 159/348 (45%), Gaps = 57/348 (16%) Query: 2 EKDG--LCRA----DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVR-VQTGEEGM 54 +K+G +CR ++YE V +GEG +GKV + D G VALK +R V E Sbjct: 36 DKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAA 95 Query: 55 PLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPE 114 L E+ VL+ ++ + N + V + + + FE + ++ +L + Sbjct: 96 RL----EINVLKKIKEKDKEN--KFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNF 149 Query: 115 PGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSS------------------ 156 P ++ M +QL L FLH +++ H DLKP+NIL +S Sbjct: 150 QPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVK 209 Query: 157 -GQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRR 215 I++ADFG A T++V T YR PEV+L+ +A P D+WS+GCI E +R Sbjct: 210 NTSIRVADFGSATFDHEHH--TTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRG 267 Query: 216 KPLFRGSSDVDQLGKILDVIG----------------LPGEEDWPRDVALPRQAFHSKSA 259 LF+ + + L + ++G G W + + R ++ Sbjct: 268 FTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYV--KENC 325 Query: 260 QPIEKFVTDIDELGK----DLLLKCLTFNPAKRISAYSALSHPYFQDL 303 +P++ ++ D L DL+ + L F+PA+RI+ AL HP+F L Sbjct: 326 KPLKSYMLQ-DSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGL 372 >6O6Q-A nrPDB Length = 335 Score = 119 bits (297), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 83/309 (26%), Positives = 157/309 (50%), Gaps = 41/309 (13%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVA-----LKRVRVQTGEEGMPLSTIREVAVL 65 + YE + ++G G Y +VF DL+ + V +KR +++ RE+++L Sbjct: 41 ENYEILRKLGRGKYSEVFLGIDLEKREKVVIKVLKPVKRKKIK-----------REISIL 89 Query: 66 RHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKD 124 ++L + PN++ + DV R + L+FEH++ D + P I+ Sbjct: 90 KNL--VDGPNIIAMLDVV---REPQSKTPGLIFEHINNIDFRSLY-----PTFTDYDIRF 139 Query: 125 MMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQ-IKLADFGLARIYSFQMALTSVVVTL 183 M++LL+ LD+ HS ++HRD+KP N+++ + ++L D+GLA Y V + Sbjct: 140 YMYELLKALDYSHSMGIMHRDVKPHNVMIDHDKKLLRLIDWGLAEYYHPGTEYNVRVASR 199 Query: 184 WYRAPEVLLQSS-YATPVDLWSVGCIFAEM-FRRKPLFRGSSDVDQLGKILDVIGLPGEE 241 +++ PE+L+ Y +D+WS GC+ A M F ++P F G S+ DQL +I+ V+G + Sbjct: 200 YFKGPELLVDYRLYDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQLVQIVRVLGSKNFK 259 Query: 242 DW--PRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLL--------KCLTFNPAKRISA 291 + +++L + + ++V ++E KDL+ + L ++ +R++A Sbjct: 260 KYLEKYNISLG-EEYEDIGYYNKRQWVRFMNENNKDLVSQEFLDLIDRLLRYDHQERLTA 318 Query: 292 YSALSHPYF 300 A+ H YF Sbjct: 319 KEAMKHAYF 327 >3LIJ-A nrPDB Length = 494 Score = 117 bits (294), Expect = 5e-27, Method: Compositional matrix adjust. Identities = 97/319 (30%), Positives = 149/319 (46%), Gaps = 46/319 (14%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 + Y+ V ++G GAYG+V RD K A+K +R + + EVAVL+ L+ Sbjct: 37 EMYQRVKKLGSGAYGEVLLCRD-KVTHVERAIKIIRKTSVSTSSNSKLLEEVAVLKLLD- 94 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ----DLTTYLDKVPEPGVPTETIKDMM 126 HPN+++L+D R LV E D + K E ++ Sbjct: 95 --HPNIMKLYDFFEDKRN-----YYLVMECYKGGELFDEIIHRMKFNEVDAAV-----II 142 Query: 127 FQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQ---IKLADFGLARIYSFQMALTSVVVTL 183 Q+L G+ +LH H +VHRDLKP+N+L+ S + IK+ DFGL+ ++ Q + + T Sbjct: 143 KQVLSGVTYLHKHNIVHRDLKPENLLLESKEKDALIKIVDFGLSAVFENQKKMKERLGTA 202 Query: 184 WYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDW 243 +Y APEV L+ Y D+WS+G I + P F G +D + L Sbjct: 203 YYIAPEV-LRKKYDEKCDVWSIGVILFILLAGYPPFGGQTDQEIL--------------- 246 Query: 244 PRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDL 303 R V + F S + ++ E KDL+ + L F+ +RISA AL HP+ +++ Sbjct: 247 -RKVEKGKYTFDSPEWK-------NVSEGAKDLIKQMLQFDSQRRISAQQALEHPWIKEM 298 Query: 304 ERCKENLDSHLPPSQNTSE 322 KE+ LP N E Sbjct: 299 CSKKES-GIELPSLANAIE 316 >6FYV-A nrPDB Length = 337 Score = 115 bits (289), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 97/336 (28%), Positives = 160/336 (47%), Gaps = 55/336 (16%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR-EVAVLRHLET 70 +YE V +GEGA+GKV + D G VA+K V+ G R E+ VL HL + Sbjct: 15 RYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVK----NVGRYREAARSEIQVLEHLNS 70 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGV---PTETIKDMMF 127 + +V R V + D + +VFE + L+TY D + E + I+ M + Sbjct: 71 TDPNSVFRC--VQMLEWFDHHGHVCIVFELLG--LSTY-DFIKENSFLPFQIDHIRQMAY 125 Query: 128 QLLRGLDFLHSHRVVHRDLKPQNILVTSSG-------------------QIKLADFGLAR 168 Q+ + ++FLH +++ H DLKP+NIL S IK+ DFG A Sbjct: 126 QICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSA- 184 Query: 169 IYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQL 228 Y + +++V T YRAPEV+L ++ P D+WS+GCI E + +F+ + L Sbjct: 185 TYDDEHH-STLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHL 243 Query: 229 GKILDVIG-LP---------------GEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDEL 272 + ++G +P + DW + R + +P+++F+ DE Sbjct: 244 AMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYV--RRRCKPLKEFMLCHDEE 301 Query: 273 GK---DLLLKCLTFNPAKRISAYSALSHPYFQDLER 305 + DL+ + L ++P +RI+ AL HP+F L++ Sbjct: 302 HEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKK 337 >3NCG-A nrPDB Length = 486 Score = 115 bits (288), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 83/295 (28%), Positives = 143/295 (48%), Gaps = 39/295 (13%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 ++Y V +G+G++G+V K +D + A+K + + + + +REV +L+ L+ Sbjct: 22 ERYNIVCMLGKGSFGEVLKCKDRITQQEY-AVKVINKASAKNKDTSTILREVELLKKLD- 79 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFE-HVDQDLTTYLDKVPEPGVPTETIKDMMFQL 129 HPN+++LF++ S + +V E + +L + + + ++ Q+ Sbjct: 80 --HPNIMKLFEILEDS-----SSFYIVGELYTGGEL--FDEIIKRKRFSEHDAARIIKQV 130 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQ---IKLADFGLARIYSFQMALTSVVVTLWYR 186 G+ ++H H +VHRDLKP+NIL+ S + IK+ DFGL+ + + + T +Y Sbjct: 131 FSGITYMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYI 190 Query: 187 APEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRD 246 APEV L+ +Y D+WS G I + P F G ++ D L ++ E Sbjct: 191 APEV-LRGTYDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRV---------ETGKYA 240 Query: 247 VALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQ 301 LP+ S A KDL+ K LTF+P+ RI+A L HP+ Q Sbjct: 241 FDLPQWRTISDDA--------------KDLIRKMLTFHPSLRITATQCLEHPWIQ 281 >6EII-A nrPDB Length = 352 Score = 115 bits (287), Expect = 4e-26, Method: Compositional matrix adjust. Identities = 89/311 (28%), Positives = 148/311 (47%), Gaps = 48/311 (15%) Query: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 Y+ V ++G G Y +VF+A ++ N + V V+ + + + + Sbjct: 62 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLR--------G 113 Query: 73 HPNVVRLFDVCT--VSRTDRETKLTLVFEHVD--------QDLTTYLDKVPEPGVPTETI 122 PN++ L D+ VSRT LVFEHV+ Q LT Y I Sbjct: 114 GPNIITLADIVKDPVSRTP-----ALVFEHVNNTDFKQLYQTLTDY------------DI 156 Query: 123 KDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSG-QIKLADFGLARIYSFQMALTSVVV 181 + M+++L+ LD+ HS ++HRD+KP N+++ +++L D+GLA Y V Sbjct: 157 RFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVA 216 Query: 182 TLWYRAPEVLLQSS-YATPVDLWSVGCIFAEM-FRRKPLFRGSSDVDQLGKILDVIGLPG 239 + +++ PE+L+ Y +D+WS+GC+ A M FR++P F G + DQL +I V+G Sbjct: 217 SRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTED 276 Query: 240 EEDWPRDVAL---PR--QAFHSKSAQPIEKFVTDIDEL-----GKDLLLKCLTFNPAKRI 289 D+ + PR S + E+FV ++ D L K L ++ R+ Sbjct: 277 LYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRL 336 Query: 290 SAYSALSHPYF 300 +A A+ HPYF Sbjct: 337 TAREAMEHPYF 347 >4MD7-E nrPDB Length = 391 Score = 114 bits (286), Expect = 5e-26, Method: Compositional matrix adjust. Identities = 93/311 (29%), Positives = 152/311 (48%), Gaps = 48/311 (15%) Query: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 Y+ V ++G G Y +VF+A ++ N ++V V+ + RE+ +L +L Sbjct: 39 YQLVRKLGRGKYSEVFEAINITNN------EKVVVKILKPVKKKKIKREIKILENLRG-- 90 Query: 73 HPNVVRLFDVCT--VSRTDRETKLTLVFEHVD--------QDLTTYLDKVPEPGVPTETI 122 PN++ L D+ VSRT LVFEHV+ Q LT Y I Sbjct: 91 GPNIITLADIVKDPVSRTP-----ALVFEHVNNTDFKQLYQTLTDY------------DI 133 Query: 123 KDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSG-QIKLADFGLARIYSFQMALTSVVV 181 + M+++L+ LD+ HS ++HRD+KP N+++ +++L D+GLA Y V Sbjct: 134 RFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVA 193 Query: 182 TLWYRAPEVLLQSS-YATPVDLWSVGCIFAEM-FRRKPLFRGSSDVDQLGKILDVIGLPG 239 + +++ PE+L+ Y +D+WS+GC+ A M FR++P F G + DQL +I V+G Sbjct: 194 SRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTED 253 Query: 240 EEDWPRDVAL---PR--QAFHSKSAQPIEKFVTD-----IDELGKDLLLKCLTFNPAKRI 289 D+ + PR S + E+FV + D L K L ++ R+ Sbjct: 254 LYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRL 313 Query: 290 SAYSALSHPYF 300 +A A+ HPYF Sbjct: 314 TAREAMEHPYF 324 >3DFA-A nrPDB Length = 286 Score = 114 bits (285), Expect = 5e-26, Method: Compositional matrix adjust. Identities = 83/295 (28%), Positives = 143/295 (48%), Gaps = 39/295 (13%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 ++Y V +G+G++G+V K +D + A+K + + + + +REV +L+ L+ Sbjct: 22 ERYNIVCMLGKGSFGEVLKCKDRITQQEY-AVKVINKASAKNKDTSTILREVELLKKLD- 79 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFE-HVDQDLTTYLDKVPEPGVPTETIKDMMFQL 129 HPN+++LF++ S + +V E + +L + + + ++ Q+ Sbjct: 80 --HPNIMKLFEILEDS-----SSFYIVGELYTGGEL--FDEIIKRKRFSEHDAARIIKQV 130 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQ---IKLADFGLARIYSFQMALTSVVVTLWYR 186 G+ ++H H +VHRDLKP+NIL+ S + IK+ DFGL+ + + + T +Y Sbjct: 131 FSGITYMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYI 190 Query: 187 APEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRD 246 APEV L+ +Y D+WS G I + P F G ++ D L ++ E Sbjct: 191 APEV-LRGTYDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRV---------ETGKYA 240 Query: 247 VALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQ 301 LP+ S A KDL+ K LTF+P+ RI+A L HP+ Q Sbjct: 241 FDLPQWRTISDDA--------------KDLIRKMLTFHPSLRITATQCLEHPWIQ 281 >6HMD-A nrPDB Length = 365 Score = 112 bits (280), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 82/303 (27%), Positives = 145/303 (47%), Gaps = 32/303 (10%) Query: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 Y+ V ++G G Y +VF+A ++ N R V V+ + + + + Sbjct: 55 YQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLR--------G 106 Query: 73 HPNVVRLFDVCT--VSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130 N+++L D VS+T LVFE+++ L ++ + I+ M++LL Sbjct: 107 GTNIIKLIDTVKDPVSKTP-----ALVFEYINNTDFKQLYQI----LTDFDIRFYMYELL 157 Query: 131 RGLDFLHSHRVVHRDLKPQNILVT-SSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPE 189 + LD+ HS ++HRD+KP N+++ +++L D+GLA Y V + +++ PE Sbjct: 158 KALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPE 217 Query: 190 VLLQSS-YATPVDLWSVGCIFAEM-FRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDV 247 +L+ Y +D+WS+GC+ A M FRR+P F G + DQL +I V+G + + Sbjct: 218 LLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKY 277 Query: 248 ALP-----RQAFHSKSAQPIEKFVTD-----IDELGKDLLLKCLTFNPAKRISAYSALSH 297 + S + E F+ + DLL K L ++ +R++A A+ H Sbjct: 278 HIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEH 337 Query: 298 PYF 300 PYF Sbjct: 338 PYF 340 >4RGJ-A nrPDB Length = 520 Score = 112 bits (280), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 90/320 (28%), Positives = 153/320 (47%), Gaps = 56/320 (17%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRF----VALKRVRVQTGEEGMPLSTIREVAVL 65 ++QY+ + +G+G++G+V +RD G + ++ K V+ +T +E S +REV +L Sbjct: 59 NEQYKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKE----SLLREVELL 114 Query: 66 RHLETFEHPNVVRLFDVCTVSR-----TDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTE 120 + L+ H N+++L++ + +D T L E + + +D Sbjct: 115 KMLD---HINIMKLYEFFEDNNYYYLVSDVYTGGELFDEIISRKRFYEID-------AAR 164 Query: 121 TIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQ----IKLADFGLARIYSFQMAL 176 IK Q+L G+ ++H + VVHRDLKP+NIL+ + + IK+ DFGL+ + + + Sbjct: 165 IIK----QILSGITYMHKNNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHFEYSKKM 220 Query: 177 TSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIG 236 + T +Y AP+V L +Y D+WS G I + P F GS++ D L K+ Sbjct: 221 KDKIGTAYYIAPDV-LHGTYDEKCDIWSCGVILYILLSGCPPFNGSNEYDILKKV----- 274 Query: 237 LPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALS 296 E LP+ I + KDL+ K L + A RISA AL Sbjct: 275 ----EAGKYTFDLPQ--------------FKKISDKAKDLIKKMLMYTSAVRISARDALE 316 Query: 297 HPYFQDLERCKENLDSHLPP 316 H + + + K+NL+ +P Sbjct: 317 HEWIK-MMTSKDNLNIDIPS 335 >2WO6-A nrPDB Length = 382 Score = 111 bits (278), Expect = 3e-25, Method: Compositional matrix adjust. Identities = 93/337 (27%), Positives = 155/337 (45%), Gaps = 61/337 (18%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETF 71 +YE + IG+G++G+V KA D + +VA+K ++ + +R + ++ Sbjct: 55 RYEIDSLIGKGSFGQVVKAYD-RVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMN----- 108 Query: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLR 131 +H ++ + V L LVFE + +L L GV + Q+ Sbjct: 109 KHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCT 168 Query: 132 GLDFLHSHR--VVHRDLKPQNILVTSSGQ--IKLADFGLA-----RIYSFQMALTSVVVT 182 L FL + ++H DLKP+NIL+ + + IK+ DFG + RIY + + + Sbjct: 169 ALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQY-------IQS 221 Query: 183 LWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLP---- 238 +YR+PEVLL Y +D+WS+GCI EM +PLF G+++VDQ+ KI++V+G+P Sbjct: 222 RFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHI 281 Query: 239 ----------------------GEEDWPRDVALP-RQAFHS-----------KSAQPIEK 264 +D R+ P + H+ + A Sbjct: 282 LDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGH 341 Query: 265 FVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQ 301 V D + KDL+L+ L ++P RI Y AL H +F+ Sbjct: 342 TVADYLKF-KDLILRMLDYDPKTRIQPYYALQHSFFK 377 >4LG4-A nrPDB Length = 299 Score = 109 bits (273), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 82/307 (26%), Positives = 149/307 (48%), Gaps = 49/307 (15%) Query: 3 KDGLCRADQQ-YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIRE 61 +D L + ++ ++ + ++GEG+YG VFKA K G+ VA+K+V V++ + + I+E Sbjct: 2 EDSLTKQPEEVFDVLEKLGEGSYGSVFKAIH-KESGQVVAIKQVPVESDLQEI----IKE 56 Query: 62 VAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTET 121 +++++ ++ P VV+ + + T L +V E+ + + ++ + + Sbjct: 57 ISIMQQCDS---PYVVKYY-----GSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDE 108 Query: 122 IKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVV 181 I ++ L+GL++LH R +HR++K NIL+ + G KLADFG+A + MA + V+ Sbjct: 109 IATILKSTLKGLEYLHFMRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVI 168 Query: 182 -TLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLP-- 238 T ++ APEV+ + Y D+WS+G EM KP + +D+ + I + P Sbjct: 169 GTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPY---ADIHPMRAIFMIPTNPPP 225 Query: 239 ---GEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSAL 295 E W D D + KCL NP +R +A L Sbjct: 226 TFRKPELWSDDFT--------------------------DFVKKCLVKNPEQRATATQLL 259 Query: 296 SHPYFQD 302 HP+ ++ Sbjct: 260 QHPFIKN 266 >6AO5-A nrPDB Length = 362 Score = 109 bits (272), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 82/307 (26%), Positives = 149/307 (48%), Gaps = 49/307 (15%) Query: 3 KDGLCRADQQ-YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIRE 61 +D L + ++ ++ + ++GEG+YG VFKA K G+ VA+K+V V++ + + I+E Sbjct: 1 EDSLTKQPEEVFDVLEKLGEGSYGSVFKAIH-KESGQVVAIKQVPVESDLQEI----IKE 55 Query: 62 VAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTET 121 +++++ ++ P VV+ + + T L +V E+ + + ++ + + Sbjct: 56 ISIMQQCDS---PYVVKYY-----GSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDE 107 Query: 122 IKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVV 181 I ++ L+GL++LH R +HR++K NIL+ + G KLADFG+A + MA + V+ Sbjct: 108 IATILKSTLKGLEYLHFMRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVI 167 Query: 182 -TLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLP-- 238 T ++ APEV+ + Y D+WS+G EM KP + +D+ + I + P Sbjct: 168 GTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPY---ADIHPMRAIFMIPTNPPP 224 Query: 239 ---GEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSAL 295 E W D D + KCL NP +R +A L Sbjct: 225 TFRKPELWSDDFT--------------------------DFVKKCLVKNPEQRATATQLL 258 Query: 296 SHPYFQD 302 HP+ ++ Sbjct: 259 QHPFIKN 265 >4IAN-A nrPDB Length = 358 Score = 109 bits (272), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 94/335 (28%), Positives = 148/335 (44%), Gaps = 55/335 (16%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLE 69 D++Y G+G + V +ARD + VA+K +R E M + ++E+ L+ L Sbjct: 29 DKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIR---NNELMQKTGLKELEFLKKLN 85 Query: 70 TFEHPN---VVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKV-PEPGVPTETIKDM 125 + + +RLF + L LVFE + +L L K + G+ + ++ Sbjct: 86 DADPDDKFHCLRLF-----RHFYHKQHLCLVFEPLSMNLREVLKKYGKDVGLHIKAVRSY 140 Query: 126 MFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQI-KLADFGLARIYSFQMALTSVVVTLW 184 QL L L ++H D+KP NILV S I KL DFG A + +T +V+ + Sbjct: 141 SQQLFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSAS-HVADNDITPYLVSRF 199 Query: 185 YRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIG-LPGEEDW 243 YRAPE+++ SY +D+WSVGC E++ K LF G ++ L +D+ G +P + Sbjct: 200 YRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPNK--M 257 Query: 244 PRDVALPRQAFHSK---------------------SAQPIEKFVTDIDELG--------- 273 R Q F + P + + D+ +G Sbjct: 258 IRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLADL--IGCQRLPEDQR 315 Query: 274 ------KDLLLKCLTFNPAKRISAYSALSHPYFQD 302 KDLL + L +PAKRIS AL H + Q+ Sbjct: 316 KKVHQLKDLLDQILMLDPAKRISINQALQHAFIQE 350 >6FD3-A nrPDB Length = 300 Score = 108 bits (270), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 86/292 (29%), Positives = 144/292 (49%), Gaps = 38/292 (13%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 ++Y +IG+GA G V+ A D+ G + VA+K++ +Q ++ I E+ V+R Sbjct: 22 KKYTRFEKIGQGASGTVYTALDIATG-QEVAIKQMNLQ--QQPKKELIINEILVMRE--- 75 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130 ++PN+V D V +L +V E++ T D V E + I + + L Sbjct: 76 NKNPNIVNYLDSYLVG-----DELWVVMEYLAGGSLT--DVVTETCMDEGQIAAVCRECL 128 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGL-ARIYSFQMALTSVVVTLWYRAPE 189 + LDFLHS++V+HRD+K NIL+ G +KL DFG A+I Q +++V T ++ APE Sbjct: 129 QALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPE 188 Query: 190 VLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVAL 249 V+ + +Y VD+WS+G + EM +P + + + L ++ G P ++ R A+ Sbjct: 189 VVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRAL-YLIATNGTPELQNPERLSAV 247 Query: 250 PRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQ 301 R D L +CL + +R SA L HP+ + Sbjct: 248 FR-----------------------DFLNRCLEMDVDRRGSAKELLQHPFLK 276 >3HZT-A nrPDB Length = 467 Score = 108 bits (269), Expect = 4e-24, Method: Compositional matrix adjust. Identities = 87/294 (29%), Positives = 135/294 (45%), Gaps = 40/294 (13%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGR--FVALKRVRVQTGEEGMPLSTIREVAVLRHLE 69 +Y+ V ++G GAYG+V +D G +K+ V T L + EVAVL+ L+ Sbjct: 5 RYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGAL--LDEVAVLKQLD 62 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQL 129 HPN+++L++ R LV E V + + + + +M Q+ Sbjct: 63 ---HPNIMKLYEFFEDKRN-----YYLVME-VYRGGELFDEIILRQKFSEVDAAVIMKQV 113 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQ---IKLADFGLARIYSFQMALTSVVVTLWYR 186 L G +LH H +VHRDLKP+N+L+ S + IK+ DFGL+ + + + T +Y Sbjct: 114 LSGTTYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYI 173 Query: 187 APEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRD 246 APEV L+ Y D+WS G I + P F G +D + L ++ DW Sbjct: 174 APEV-LRKKYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEKGKFSFDPPDW--- 229 Query: 247 VALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 T + + K L+ LT+ P+KRISA AL+HP+ Sbjct: 230 --------------------TQVSDEAKQLVKLMLTYEPSKRISAEEALNHPWI 263 >3DXN-A nrPDB Length = 287 Score = 108 bits (269), Expect = 5e-24, Method: Compositional matrix adjust. Identities = 87/294 (29%), Positives = 135/294 (45%), Gaps = 40/294 (13%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGR--FVALKRVRVQTGEEGMPLSTIREVAVLRHLE 69 +Y+ V ++G GAYG+V +D G +K+ V T L + EVAVL+ L+ Sbjct: 22 RYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGAL--LDEVAVLKQLD 79 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQL 129 HPN+++L++ R LV E V + + + + +M Q+ Sbjct: 80 ---HPNIMKLYEFFEDKRN-----YYLVME-VYRGGELFDEIILRQKFSEVDAAVIMKQV 130 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQ---IKLADFGLARIYSFQMALTSVVVTLWYR 186 L G +LH H +VHRDLKP+N+L+ S + IK+ DFGL+ + + + T +Y Sbjct: 131 LSGTTYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYI 190 Query: 187 APEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRD 246 APEV L+ Y D+WS G I + P F G +D + L ++ DW Sbjct: 191 APEV-LRKKYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEKGKFSFDPPDW--- 246 Query: 247 VALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 T + + K L+ LT+ P+KRISA AL+HP+ Sbjct: 247 --------------------TQVSDEAKQLVKLMLTYEPSKRISAEEALNHPWI 280 >2WQN-A nrPDB Length = 310 Score = 108 bits (269), Expect = 5e-24, Method: Compositional matrix adjust. Identities = 72/225 (32%), Positives = 120/225 (53%), Gaps = 20/225 (8%) Query: 8 RADQQYECVA------EIGEGAYGKVFKARDLKNGGRFVALKRVRV-QTGEEGMPLSTIR 60 R D Y +A +IG G + +V++A L +G VALK+V++ + I+ Sbjct: 23 RPDMGYNTLANFRIEKKIGRGQFSEVYRAACLLDGVP-VALKKVQIFDLMDAKARADCIK 81 Query: 61 EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLD--KVPEPGV 117 E+ +L+ L HPNV++ + + + +L +V E D DL+ + K + + Sbjct: 82 EIDLLKQLN---HPNVIKYY-----ASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLI 133 Query: 118 PTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQ-MAL 176 P T+ QL L+ +HS RV+HRD+KP N+ +T++G +KL D GL R +S + A Sbjct: 134 PERTVWKYFVQLCSALEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAA 193 Query: 177 TSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRG 221 S+V T +Y +PE + ++ Y D+WS+GC+ EM + F G Sbjct: 194 HSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYG 238 >5JN2-A nrPDB Length = 525 Score = 107 bits (268), Expect = 6e-24, Method: Compositional matrix adjust. Identities = 87/316 (27%), Positives = 152/316 (48%), Gaps = 46/316 (14%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGG----RFVALKRVRVQTGEEGMPLSTIREVAVLRH 67 +Y+ +G+G++G+V +D G + ++ ++V+ +T +E S +REV +L+ Sbjct: 68 RYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKE----SLLREVQLLKQ 123 Query: 68 LETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMF 127 L+ HPN+++L++ + + LV E V + + + ++ Sbjct: 124 LD---HPNIMKLYEFF-----EDKGYFYLVGE-VYTGGELFDEIISRKRFSEVDAARIIR 174 Query: 128 QLLRGLDFLHSHRVVHRDLKPQNILVTSSGQ---IKLADFGLARIYSFQMALTSVVVTLW 184 Q+L G+ ++H +++VHRDLKP+N+L+ S + I++ DFGL+ + + + T + Sbjct: 175 QVLSGITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAY 234 Query: 185 YRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWP 244 Y APEV L +Y D+WS G I + P F G+++ D L K+ E Sbjct: 235 YIAPEV-LHGTYDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKV---------EKGK 284 Query: 245 RDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLE 304 LP+ S+SA KDL+ K LT+ P+ RISA AL H + Q Sbjct: 285 YTFELPQWKKVSESA--------------KDLIRKMLTYVPSMRISARDALDHEWIQTY- 329 Query: 305 RCKENLDSHLPPSQNT 320 KE + +P N Sbjct: 330 -TKEQISVDVPSLDNA 344 >2XNP-A nrPDB Length = 279 Score = 107 bits (266), Expect = 9e-24, Method: Compositional matrix adjust. Identities = 76/230 (33%), Positives = 116/230 (50%), Gaps = 16/230 (6%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 + YE + IG G+YG+ K R K+ G+ + K + + E + EV +LR L+ Sbjct: 6 EDYEVLYTIGTGSYGRCQKIRR-KSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELK- 63 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPG--VPTETIKDMMF 127 HPN+VR +D + RT+ T L +V E+ + DL + + K + + E + +M Sbjct: 64 --HPNIVRYYDR-IIDRTN--TTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMT 118 Query: 128 QLLRGLDFLH-----SHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVV- 181 QL L H H V+HRDLKP N+ + +KL DFGLARI + + V Sbjct: 119 QLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVG 178 Query: 182 TLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKI 231 T +Y +PE + + SY D+WS+GC+ E+ P F S + GKI Sbjct: 179 TPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKI 228 >3COM-A nrPDB Length = 314 Score = 106 bits (264), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 79/306 (25%), Positives = 150/306 (49%), Gaps = 49/306 (16%) Query: 1 MEKDGLCRADQQ-YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTI 59 +++D L + ++ ++ + ++GEG+YG V+KA K G+ VA+K+V V++ + + I Sbjct: 18 LDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIH-KETGQIVAIKQVPVESDLQEI----I 72 Query: 60 REVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPT 119 +E+++++ ++ P+VV+ + + T L +V E+ + + ++ + Sbjct: 73 KEISIMQQCDS---PHVVKYY-----GSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTE 124 Query: 120 ETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSV 179 + I ++ L+GL++LH R +HRD+K NIL+ + G KLADFG+A + MA + Sbjct: 125 DEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNT 184 Query: 180 VV-TLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLP 238 V+ T ++ APEV+ + Y D+WS+G EM KP + +D+ + I + P Sbjct: 185 VIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPY---ADIHPMRAIFMIPTNP 241 Query: 239 -----GEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYS 293 E W + D + +CL +P +R +A Sbjct: 242 PPTFRKPELWSDNFT--------------------------DFVKQCLVKSPEQRATATQ 275 Query: 294 ALSHPY 299 L HP+ Sbjct: 276 LLQHPF 281 >5YKS-A nrPDB Length = 377 Score = 106 bits (264), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 86/298 (28%), Positives = 142/298 (47%), Gaps = 46/298 (15%) Query: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALK---RVRVQTGEEGMPLSTIREVAVLRHLE 69 Y+ +G G + V AR + G + VA+K + ++ T L+T +R ++ Sbjct: 37 YDLDKTLGRGHFAVVKLARHVFTGEK-VAVKVIDKTKLDT------LATGHLFQEVRCMK 89 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQ 128 +HPN+VRL++V D +TKL L+ E D D+ Y+ K E G+ + K Q Sbjct: 90 LVQHPNIVRLYEV-----IDTQTKLYLILELGDGGDMFDYIMK-HEEGLNEDLAKKYFAQ 143 Query: 129 LLRGLDFLHSHRVVHRDLKPQNIL-VTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRA 187 ++ + + H VVHRDLKP+N++ G +KL DFG + + LT+ +L Y A Sbjct: 144 IVHAISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSA 203 Query: 188 PEVLLQSSYATP-VDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRD 246 PE+LL Y P VD+WS+G I + +P F+ ++D + L I+D Sbjct: 204 PEILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMD------------- 250 Query: 247 VALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLE 304 K P + + + KDL+ + L +P +R S +HP+ Q ++ Sbjct: 251 ---------CKYTVP-----SHVSKECKDLITRMLQRDPKRRASLEEIENHPWLQGVD 294 >3MA6-A nrPDB Length = 298 Score = 105 bits (262), Expect = 3e-23, Method: Compositional matrix adjust. Identities = 82/290 (28%), Positives = 143/290 (49%), Gaps = 44/290 (15%) Query: 19 IGEGAYGKVFKARDLKNGG----RFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHP 74 +G+G++G+V +D G + ++ ++V+ +T +E S +REV +L+ L+ HP Sbjct: 40 LGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKE----SLLREVQLLKQLD---HP 92 Query: 75 NVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLD 134 N+++L++ + + LV E V + + + ++ Q+L G+ Sbjct: 93 NIMKLYEFF-----EDKGYFYLVGE-VYTGGELFDEIISRKRFSEVDAARIIRQVLSGIT 146 Query: 135 FLHSHRVVHRDLKPQNILVTSSGQ---IKLADFGLARIYSFQMALTSVVVTLWYRAPEVL 191 ++H +++VHRDLKP+N+L+ S + I++ DFGL+ + + + T +Y APEV Sbjct: 147 YMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEV- 205 Query: 192 LQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPR 251 L +Y D+WS G I + P F G+++ D L K+ E LP+ Sbjct: 206 LHGTYDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKV---------EKGKYTFELPQ 256 Query: 252 QAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQ 301 S+SA KDL+ K LT+ P+ RISA AL H + Q Sbjct: 257 WKKVSESA--------------KDLIRKMLTYVPSMRISARDALDHEWIQ 292 >4FG9-A nrPDB Length = 320 Score = 104 bits (259), Expect = 6e-23, Method: Compositional matrix adjust. Identities = 86/286 (30%), Positives = 131/286 (45%), Gaps = 39/286 (13%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVR 78 +G GA+ +V A D K + VA+K + + EG S E+AVL ++ HPN+V Sbjct: 26 LGTGAFSEVILAED-KRTQKLVAIKCI-AKEALEGKEGSMENEIAVLHKIK---HPNIVA 80 Query: 79 LFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTE-TIKDMMFQLLRGLDFLH 137 L D+ + L L+ + V D++ E G TE ++FQ+L + +LH Sbjct: 81 LDDI-----YESGGHLYLIMQLVSG--GELFDRIVEKGFYTERDASRLIFQVLDAVKYLH 133 Query: 138 SHRVVHRDLKPQNILVTS---SGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQS 194 +VHRDLKP+N+L S +I ++DFGL+++ L++ T Y APEVL Q Sbjct: 134 DLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEVLAQK 193 Query: 195 SYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAF 254 Y+ VD WS+G I + P F +D +IL E D P Sbjct: 194 PYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKA---EYEFDSP---------- 240 Query: 255 HSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 + DI + KD + + +P KR + AL HP+ Sbjct: 241 ----------YWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWI 276 >6QAU-A nrPDB Length = 280 Score = 103 bits (256), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 70/228 (30%), Positives = 113/228 (49%), Gaps = 21/228 (9%) Query: 9 ADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHL 68 D +Y +G GA+ VF+ R + VA+K + + + L +E+ +L+ L Sbjct: 9 GDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLG-KEIKILKEL 67 Query: 69 ETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMF 127 + H N+V L+DV + + + LV E+ + DL YL + + +TI+ + Sbjct: 68 Q---HENIVALYDVQELPNS-----VFLVMEYCNGGDLADYLQ--AKGTLSEDTIRVFLH 117 Query: 128 QLLRGLDFLHSHRVVHRDLKPQNILVT---------SSGQIKLADFGLARIYSFQMALTS 178 Q+ + LHS ++HRDLKPQNIL++ S +IK+ADFG AR M Sbjct: 118 QIAAAMRILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAAD 177 Query: 179 VVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVD 226 + + Y APEV++ Y DLWS+G + + KP F+ +S D Sbjct: 178 LCGSPMYMAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQD 225 >4MVF-A nrPDB Length = 506 Score = 102 bits (255), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 86/317 (27%), Positives = 142/317 (44%), Gaps = 52/317 (16%) Query: 6 LCRA---DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTI--- 59 LC + + +Y ++G+G YG V+K D K + A+K E+ L I Sbjct: 49 LCHSGKLEDKYIIDEKLGQGTYGCVYKGID-KVTNQLYAIKE------EKKDRLKNINRF 101 Query: 60 -REVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVP 118 +E+ +++ L+ HPN+V+L++ + + + L+ E D + E G Sbjct: 102 FQEIEIMKKLD---HPNIVKLYET-----YENDNYIYLIMELCSG--RELFDSIIENGSF 151 Query: 119 TE-TIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQ---IKLADFGLARIYSFQM 174 TE +M Q+ + +LHS +VHRDLKP+N L S + +K+ DFGL++ Sbjct: 152 TEKNAATIMKQIFSAIFYLHSLNIVHRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTGE 211 Query: 175 ALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDV 234 T+ T +Y AP+V L Y D+WS G I + P F G +D + L K+ Sbjct: 212 FTTTKAGTPYYVAPQV-LDGKYDKKCDIWSSGVIMYTLLCGYPPFYGDTDNEVLKKVKKG 270 Query: 235 IGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSA 294 E DW I K+L+ K LT+NP +R + A Sbjct: 271 EFCFYENDWGS-----------------------ISSDAKNLITKLLTYNPNERCTIEEA 307 Query: 295 LSHPYFQDLERCKENLD 311 L+HP+ + + E+++ Sbjct: 308 LNHPWITQMTKSHEHVE 324 >3Q53-A nrPDB Length = 306 Score = 102 bits (255), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 83/292 (28%), Positives = 144/292 (49%), Gaps = 38/292 (13%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 ++Y +IG+GA G V+ A D+ G + VA++++ +Q ++ I E+ V+R Sbjct: 21 KKYTRFEKIGQGASGTVYTAMDVATG-QEVAIRQMNLQ--QQPKKELIINEILVMRE--- 74 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130 ++PN+V D V +L +V E++ T D V E + I + + L Sbjct: 75 NKNPNIVNYLDSYLVG-----DELWVVMEYLAGGSLT--DVVTETCMDEGQIAAVCRECL 127 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGL-ARIYSFQMALTSVVVTLWYRAPE 189 + L+FLHS++V+HRD+K NIL+ G +KL DFG A+I Q +++V T ++ APE Sbjct: 128 QALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPE 187 Query: 190 VLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVAL 249 V+ + +Y VD+WS+G + EM +P + + + + L +I G Sbjct: 188 VVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPL----RALYLIATNG---------- 233 Query: 250 PRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQ 301 + Q EK + + +D L +CL + KR SA + H + + Sbjct: 234 ------TPELQNPEK----LSAIFRDFLNRCLEMDVEKRGSAKELIQHQFLK 275 >3MN3-A nrPDB Length = 271 Score = 102 bits (255), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 70/217 (32%), Positives = 114/217 (52%), Gaps = 19/217 (8%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQT-GEEGMPLSTIREVAVLRHLET 70 Y+ V +GEG++GKV A G + VALK + + + M RE++ LR L Sbjct: 5 NYQIVKTLGEGSFGKVKLAYHTTTGQK-VALKIINKKVLAKSDMQGRIEREISYLRLLR- 62 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYL---DKVPEPGVPTETIKDMMF 127 HP++++L+DV + ++ +V E+ +L Y+ DK+ E + + Sbjct: 63 --HPHIIKLYDVIK-----SKDEIIMVIEYAGNELFDYIVQRDKMSE-----QEARRFFQ 110 Query: 128 QLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRA 187 Q++ +++ H H++VHRDLKP+N+L+ +K+ADFGL+ I + L + + Y A Sbjct: 111 QIISAVEYCHRHKIVHRDLKPENLLLDEHLNVKIADFGLSNIMTDGNFLKTSCGSPNYAA 170 Query: 188 PEVLLQSSYATP-VDLWSVGCIFAEMFRRKPLFRGSS 223 PEV+ YA P VD+WS G I M R+ F S Sbjct: 171 PEVISGKLYAGPEVDVWSCGVILYVMLCRRLPFDDES 207 >3Q5I-A nrPDB Length = 504 Score = 102 bits (253), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 84/313 (26%), Positives = 137/313 (43%), Gaps = 64/313 (20%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRH--- 67 + Y V ++G GAYG+V ++ KNG A+K ++ ++G + + Sbjct: 36 ESYFKVRKLGSGAYGEVLLCKE-KNGHSEKAIKVIKKSQFDKGRYSDDNKNIEKFHEEIY 94 Query: 68 -----LETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETI 122 L++ +HPN+++LFDV FE D+ + + E G E I Sbjct: 95 NEISLLKSLDHPNIIKLFDV---------------FE--DKKYFYLVTEFYEGGELFEQI 137 Query: 123 -----------KDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSG---QIKLADFGLAR 168 ++M Q+L G+ +LH H +VHRD+KP+NIL+ + IK+ DFGL+ Sbjct: 138 INRHKFDECDAANIMKQILSGICYLHKHNIVHRDIKPENILLENKNSLLNIKIVDFGLSS 197 Query: 169 IYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQL 228 +S L + T +Y APEV L+ Y D+WS G I + P F G +D D + Sbjct: 198 FFSKDYKLRDRLGTAYYIAPEV-LKKKYNEKCDVWSCGVIMYILLCGYPPFGGQNDQDII 256 Query: 229 GKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKR 288 K+ DW +I + K+L+ LT++ KR Sbjct: 257 KKVEKGKYYFDFNDWK-----------------------NISDEAKELIKLMLTYDYNKR 293 Query: 289 ISAYSALSHPYFQ 301 +A AL+ + + Sbjct: 294 CTAEEALNSRWIK 306 >4QMW-A nrPDB Length = 310 Score = 102 bits (253), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 67/210 (31%), Positives = 126/210 (60%), Gaps = 15/210 (7%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLE 69 ++ + + +IG+G++G+VFK D + + VA+K + ++ E+ + +E+ VL + Sbjct: 28 EELFTKLEKIGKGSFGEVFKGIDNRTQ-KVVAIKIIDLEEAEDEIEDIQ-QEITVLSQCD 85 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTET-IKDMMFQ 128 + P V + + ++TKL ++ E++ + LD + EPG ET I ++ + Sbjct: 86 S---PYVTKYYGSYL-----KDTKLWIIMEYLGGG--SALDLL-EPGPLDETQIATILRE 134 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLA-RIYSFQMALTSVVVTLWYRA 187 +L+GLD+LHS + +HRD+K N+L++ G++KLADFG+A ++ Q+ + V T ++ A Sbjct: 135 ILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMA 194 Query: 188 PEVLLQSSYATPVDLWSVGCIFAEMFRRKP 217 PEV+ QS+Y + D+WS+G E+ R +P Sbjct: 195 PEVIKQSAYDSKADIWSLGITAIELARGEP 224 >2GCD-A nrPDB Length = 309 Score = 101 bits (252), Expect = 4e-22, Method: Compositional matrix adjust. Identities = 69/203 (33%), Positives = 106/203 (52%), Gaps = 15/203 (7%) Query: 18 EIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVV 77 EIG G++G V+ ARD++N VA+K++ + I + +R L+ HPN + Sbjct: 22 EIGHGSFGAVYFARDVRNS-EVVAIKKMSYSGKQSNEKWQDI--IKEVRFLQKLRHPNTI 78 Query: 78 RLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLH 137 + + C + RE LV E+ + L+ +P E I + L+GL +LH Sbjct: 79 Q-YRGCYL----REHTAWLVMEYCLGSASDLLEVHKKPLQEVE-IAAVTHGALQGLAYLH 132 Query: 138 SHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLL---QS 194 SH ++HRD+K NIL++ G +KL DFG A I + S V T ++ APEV+L + Sbjct: 133 SHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMA---PANSFVGTPYWMAPEVILAMDEG 189 Query: 195 SYATPVDLWSVGCIFAEMFRRKP 217 Y VD+WS+G E+ RKP Sbjct: 190 QYDGKVDVWSLGITCIELAERKP 212 >5JZN-A nrPDB Length = 280 Score = 101 bits (252), Expect = 4e-22, Method: Compositional matrix adjust. Identities = 90/302 (29%), Positives = 141/302 (46%), Gaps = 50/302 (16%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQT--GEEGMPLSTIREVAVLRHL 68 ++Y+ IG+G + V + + ++ R ALK ++ G+E M EV++LR + Sbjct: 19 ERYKVGRTIGDGNFAVVKECVE-RSTAREYALKIIKKSKCRGKEHM---IQNEVSILRRV 74 Query: 69 ETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ----DLTTYLDKVPEPGVPTETIKD 124 + HPN+V L + D T+L LV E V D T +K E Sbjct: 75 K---HPNIVLL-----IEEMDVPTELYLVMELVKGGDLFDAITSTNKYTE-----RDASG 121 Query: 125 MMFQLLRGLDFLHSHRVVHRDLKPQNILV----TSSGQIKLADFGLARIYSFQMALTSVV 180 M++ L + +LHS +VHRD+KP+N+LV S +KL DFGLA I L +V Sbjct: 122 MLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATI--VDGPLYTVC 179 Query: 181 VTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGE 240 T Y APE++ ++ Y VD+W+ G I + P FRGS D ++ + D I L G+ Sbjct: 180 GTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEV--LFDQI-LMGQ 236 Query: 241 EDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 D+P + ++ + K+L+ L + +R SA L HP+ Sbjct: 237 VDFP------------------SPYWDNVSDSAKELITMMLLVDVDQRFSAVQVLEHPWV 278 Query: 301 QD 302 D Sbjct: 279 ND 280 >2W4O-A nrPDB Length = 349 Score = 101 bits (252), Expect = 4e-22, Method: Compositional matrix adjust. Identities = 81/293 (27%), Positives = 141/293 (48%), Gaps = 45/293 (15%) Query: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR-EVAVLRHLETF 71 +E +E+G GA V++ + K + ALK ++ ++ +R E+ VL L Sbjct: 55 FEVESELGRGATSIVYRCKQ-KGTQKPYALKVLKKTVDKK-----IVRTEIGVLLRLS-- 106 Query: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTE-TIKDMMFQLL 130 HPN+++L ++ + T+++LV E V D++ E G +E D + Q+L Sbjct: 107 -HPNIIKLKEIF-----ETPTEISLVLELVTGG--ELFDRIVEKGYYSERDAADAVKQIL 158 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTS---SGQIKLADFGLARIYSFQMALTSVVVTLWYRA 187 + +LH + +VHRDLKP+N+L + +K+ADFGL++I Q+ + +V T Y A Sbjct: 159 EAVAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCA 218 Query: 188 PEVLLQSSYATPVDLWSVGCI-FAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRD 246 PE+L +Y VD+WSVG I + + +P + D +IL+ Sbjct: 219 PEILRGCAYGPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNC------------ 266 Query: 247 VALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPY 299 I + ++ KDL+ K + +P KR++ + AL HP+ Sbjct: 267 -----------EYYFISPWWDEVSLNAKDLVRKLIVLDPKKRLTTFQALQHPW 308 >1U5R-A nrPDB Length = 348 Score = 101 bits (252), Expect = 4e-22, Method: Compositional matrix adjust. Identities = 69/203 (33%), Positives = 106/203 (52%), Gaps = 15/203 (7%) Query: 18 EIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVV 77 EIG G++G V+ ARD++N VA+K++ + I + +R L+ HPN + Sbjct: 61 EIGHGSFGAVYFARDVRNS-EVVAIKKMSYSGKQSNEKWQDI--IKEVRFLQKLRHPNTI 117 Query: 78 RLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLH 137 + + C + RE LV E+ + L+ +P E I + L+GL +LH Sbjct: 118 Q-YRGCYL----REHTAWLVMEYCLGSASDLLEVHKKPLQEVE-IAAVTHGALQGLAYLH 171 Query: 138 SHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLL---QS 194 SH ++HRD+K NIL++ G +KL DFG A I + S V T ++ APEV+L + Sbjct: 172 SHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMA---PANSFVGTPYWMAPEVILAMDEG 228 Query: 195 SYATPVDLWSVGCIFAEMFRRKP 217 Y VD+WS+G E+ RKP Sbjct: 229 QYDGKVDVWSLGITCIELAERKP 251 >4KS7-A nrPDB Length = 292 Score = 101 bits (251), Expect = 5e-22, Method: Compositional matrix adjust. Identities = 84/285 (29%), Positives = 141/285 (49%), Gaps = 38/285 (13%) Query: 17 AEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNV 76 +IGEG+ G V AR+ K+ GR VA+K + ++ + L EV ++R ++H NV Sbjct: 29 VKIGEGSTGIVCLARE-KHSGRQVAVKMMDLRKQQRRELL--FNEVVIMR---DYQHFNV 82 Query: 77 VRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFL 136 V ++ V +L ++ E + T D V + + E I + +L+ L +L Sbjct: 83 VEMYKSYLVGE-----ELWVLMEFLQGGALT--DIVSQVRLNEEQIATVCEAVLQALAYL 135 Query: 137 HSHRVVHRDLKPQNILVTSSGQIKLADFGL-ARIYSFQMALTSVVVTLWYRAPEVLLQSS 195 H+ V+HRD+K +IL+T G++KL+DFG A+I S+V T ++ APEV+ +S Sbjct: 136 HAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSL 195 Query: 196 YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFH 255 YAT VD+WS+G + EM +P + S V + ++ D + P + + Sbjct: 196 YATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRD--------------SPPPKLKN 241 Query: 256 SKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 S P+ +D L + L +P +R +A L HP+ Sbjct: 242 SHKVSPVL----------RDFLERMLVRDPQERATAQELLDHPFL 276 >2JD5-A nrPDB Length = 373 Score = 100 bits (249), Expect = 8e-22, Method: Compositional matrix adjust. Identities = 90/331 (27%), Positives = 157/331 (47%), Gaps = 47/331 (14%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLE 69 D +Y V ++G G + V+ A+D+ N VA+K VR G++ + E+ +L+ + Sbjct: 18 DARYILVRKLGWGHFSTVWLAKDMVNNTH-VAMKIVR---GDKVYTEAAEDEIKLLQRVN 73 Query: 70 TFEHP--------NVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTET 121 ++ ++++L D + + +VFE + ++L + K G+P Sbjct: 74 DADNTKEDSMGANHILKLLDHFN-HKGPNGVHVVMVFEVLGENLLALIKKYEHRGIPLIY 132 Query: 122 IKDMMFQLLRGLDFLHSH-RVVHRDLKPQNILVT------SSGQIKLADFGLARIYSFQM 174 +K + QLL GLD++H ++H D+KP+N+L+ + QIK+AD G A Y Sbjct: 133 VKQISKQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNACWYDEHY 192 Query: 175 ALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLF---RGSS---DVDQL 228 T+ + T YR+PEVLL + + D+WS C+ E+ LF G S D D + Sbjct: 193 --TNSIQTREYRSPEVLLGAPWGCGADIWSTACLIFELITGDFLFEPDEGHSYTKDDDHI 250 Query: 229 GKILDVIG-LPGEEDWPRDVALPRQAFHSKSA---------QPIEKFVTDIDELGK---- 274 +I++++G LP R+ R F+S+ P+E +T+ + K Sbjct: 251 AQIIELLGELPSY--LLRNGKYTRTFFNSRGLLRNISKLKFWPLEDVLTEKYKFSKDEAK 308 Query: 275 ---DLLLKCLTFNPAKRISAYSALSHPYFQD 302 D L L +P KR A ++HP+ +D Sbjct: 309 EISDFLSPMLQLDPRKRADAGGLVNHPWLKD 339 >6HXF-B nrPDB Length = 302 Score = 100 bits (249), Expect = 8e-22, Method: Compositional matrix adjust. Identities = 86/304 (28%), Positives = 137/304 (45%), Gaps = 41/304 (13%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLE 69 ++ +E V E+G+GA+GKV+KA++ K G A K + ++ EE I E+ +L Sbjct: 18 NEVWEIVGELGDGAFGKVYKAKN-KETGALAAAKVIETKSEEELE--DYIVEIEILA--- 71 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQL 129 T +HP +V+L + KL ++ E + + G+ I+ + Q+ Sbjct: 72 TCDHPYIVKLLGAYY-----HDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQM 126 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGL-ARIYSFQMALTSVVVTLWYRAP 188 L L+FLHS R++HRDLK N+L+T G I+LADFG+ A+ S + T ++ AP Sbjct: 127 LEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAP 186 Query: 189 EVLL-----QSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDW 243 EV++ + Y D+WS+G EM + +P + + L KI Sbjct: 187 EVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKI------------ 234 Query: 244 PRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDL 303 +KS P + +D L L NP R SA L HP+ + Sbjct: 235 ------------AKSDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSI 282 Query: 304 ERCK 307 K Sbjct: 283 TSNK 286 >2VN9-A nrPDB Length = 301 Score = 100 bits (249), Expect = 9e-22, Method: Compositional matrix adjust. Identities = 91/297 (30%), Positives = 132/297 (44%), Gaps = 45/297 (15%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVA-LKRVRVQTGEEGMPLSTIREVAVLRHLET 70 +Y+ E+G+GA+ V + + G + A + + + + L RE + R L+ Sbjct: 5 EYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLE--REARICRLLK- 61 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130 HPN+VRL D + E LVF+ V + D V + Q+L Sbjct: 62 --HPNIVRLHDSIS-----EEGFHYLVFDLVTGG-ELFEDIVAREYYSEADASHCIQQIL 113 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQ---IKLADFGLA-RIYSFQMALTSVVVTLWYR 186 ++ H + +VHRDLKP+N+L+ S + +KLADFGLA + Q A T Y Sbjct: 114 ESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYL 173 Query: 187 APEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPR- 245 +PEVL + Y PVD+W+ G I + P F D DQ ++ I G D+P Sbjct: 174 SPEVLRKDPYGKPVDMWACGVILYILLVGYPPFW---DEDQ-HRLYQQIK-AGAYDFPSP 228 Query: 246 --DVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 D P KDL+ K LT NPAKRI+A AL HP+ Sbjct: 229 EWDTVTPE---------------------AKDLINKMLTINPAKRITASEALKHPWI 264 >4UZD-A nrPDB Length = 287 Score = 100 bits (248), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 81/292 (27%), Positives = 138/292 (47%), Gaps = 39/292 (13%) Query: 9 ADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRV-RVQTGEEGMPLSTIREVAVLRH 67 A + +E +G+G +G V+ AR+ K +ALK + + Q + G+ REV + H Sbjct: 6 ALEDFEIGRPLGKGKFGNVYLARE-KQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSH 64 Query: 68 LETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMF 127 L HPN++RL+ + T++ L+ E+ T Y + + + Sbjct: 65 LR---HPNILRLYGYFHDA-----TRVYLILEYAPLG-TVYRELQKLSKFDEQRTATYIT 115 Query: 128 QLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRA 187 +L L + HS RV+HRD+KP+N+L+ S+G++K+ADFG + +++ T++ TL Y Sbjct: 116 ELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWS-VHAPSSRRTTLCGTLDYLP 174 Query: 188 PEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDV 247 PE++ + VDLWS+G + E KP F ++ + +I V + Sbjct: 175 PEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRV-----------EF 223 Query: 248 ALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPY 299 P FVT E +DL+ + L NP++R L HP+ Sbjct: 224 TFP-------------DFVT---EGARDLISRLLKHNPSQRPMLREVLEHPW 259 >3GUB-A nrPDB Length = 295 Score = 99.4 bits (246), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 78/300 (26%), Positives = 138/300 (46%), Gaps = 41/300 (13%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVA--LKRVRVQTGEEGMPLSTI-REVAVLR 66 D Y+ E+G G + V K R+ G ++ A +K+ R ++ G+ I REV++L+ Sbjct: 10 DDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILK 69 Query: 67 HLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPGVPTETIKDM 125 ++ HPNV+ L +V + +T + L+ E V +L +L + + E + Sbjct: 70 EIQ---HPNVITLHEVY-----ENKTDVILIGELVAGGELFDFL--AEKESLTEEEATEF 119 Query: 126 MFQLLRGLDFLHSHRVVHRDLKPQNILVTSSG----QIKLADFGLARIYSFQMALTSVVV 181 + Q+L G+ +LHS ++ H DLKP+NI++ +IK+ DFGLA F ++ Sbjct: 120 LKQILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFG 179 Query: 182 TLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEE 241 T + APE++ D+WS+G I + F G + + L + V Sbjct: 180 TPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAV------- 232 Query: 242 DWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQ 301 + + F + SA L KD + + L +P KR++ +L HP+ + Sbjct: 233 ----NYEFEDEYFSNTSA------------LAKDFIRRLLVKDPKKRMTIQDSLQHPWIK 276 >4WNO-A nrPDB Length = 287 Score = 99.4 bits (246), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 69/218 (31%), Positives = 110/218 (50%), Gaps = 21/218 (9%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVR 78 IG GA+ VFK R VA+K + + + L +E+ +L+ L+ H N+V Sbjct: 26 IGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQTLLG-KEIKILKELK---HENIVA 81 Query: 79 LFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLH 137 L+D ++ + + LV E+ + DL YL + + +TI+ + Q+ + LH Sbjct: 82 LYDFQEMANS-----VYLVMEYCNGGDLADYLHAMRT--LSEDTIRLFLQQIAGAMRLLH 134 Query: 138 SHRVVHRDLKPQNILVTS---------SGQIKLADFGLARIYSFQMALTSVVVTLWYRAP 188 S ++HRDLKPQNIL+++ S ++K+ADFG AR M ++ + Y AP Sbjct: 135 SKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAP 194 Query: 189 EVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVD 226 EV++ Y DLWS+G I + K F+ SS D Sbjct: 195 EVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQD 232 >2J90-A nrPDB Length = 304 Score = 99.4 bits (246), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 77/304 (25%), Positives = 136/304 (44%), Gaps = 41/304 (13%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVA--LKRVRVQTGEEGMPLSTI-REVAVLR 66 + YE E+G G + V K R G + A +K+ R+ + G+ I REV +LR Sbjct: 25 EDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILR 84 Query: 67 HLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDM 125 + HPN++ L D+ + +T + L+ E V +L +L + + + Sbjct: 85 EIR---HPNIITLHDIF-----ENKTDVVLILELVSGGELFDFL--AEKESLTEDEATQF 134 Query: 126 MFQLLRGLDFLHSHRVVHRDLKPQNILVTSSG----QIKLADFGLARIYSFQMALTSVVV 181 + Q+L G+ +LHS R+ H DLKP+NI++ +IKL DFG+A ++ Sbjct: 135 LKQILDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFG 194 Query: 182 TLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEE 241 T + APE++ D+WS+G I + F G + + L I V Sbjct: 195 TPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAV------- 247 Query: 242 DWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQ 301 ++ D E++ ++ EL KD + + L +P +R++ +L H + + Sbjct: 248 NYDFD----------------EEYFSNTSELAKDFIRRLLVKDPKRRMTIAQSLEHSWIK 291 Query: 302 DLER 305 + R Sbjct: 292 AIRR 295 >3TAC-A nrPDB Length = 361 Score = 99.0 bits (245), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 89/312 (28%), Positives = 149/312 (47%), Gaps = 43/312 (13%) Query: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQ--TGEEGMPLSTIREVAVLRHLET 70 YE IG+G + V + + + G +F A+K V V T G+ ++ A + H+ Sbjct: 28 YELCEVIGKGPFSVVRRCINRETGQQF-AVKIVDVAKFTSSPGLSTEDLKREASICHM-- 84 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPG-VPTETIKD-MMF 127 +HP++V L + + + L +VFE +D DL + K + G V +E + M Sbjct: 85 LKHPHIVELLETYS-----SDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMR 139 Query: 128 QLLRGLDFLHSHRVVHRDLKPQNILVTS---SGQIKLADFGLA-RIYSFQMALTSVVVTL 183 Q+L L + H + ++HRD+KP +L+ S S +KL FG+A ++ + V T Sbjct: 140 QILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTP 199 Query: 184 WYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDW 243 + APEV+ + Y PVD+W G I + F G+ + ++ + I + G+ Sbjct: 200 HFMAPEVVKREPYGKPVDVWGCGVILFILLSGCLPFYGTKE-----RLFEGI-IKGKYKM 253 Query: 244 PRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDL 303 PRQ H I E KDL+ + L +PA+RI+ Y AL+HP+ ++ Sbjct: 254 N-----PRQWSH-------------ISESAKDLVRRMLMLDPAERITVYEALNHPWLKER 295 Query: 304 ERCKENLDSHLP 315 +R + HLP Sbjct: 296 DRYAYKI--HLP 305 >2F57-A nrPDB Length = 317 Score = 98.2 bits (243), Expect = 4e-21, Method: Compositional matrix adjust. Identities = 84/285 (29%), Positives = 139/285 (48%), Gaps = 38/285 (13%) Query: 18 EIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVV 77 +IGEG+ G V A + K+ G+ VA+K++ ++ + L EV ++R + H NVV Sbjct: 52 KIGEGSTGIVCIATE-KHTGKQVAVKKMDLRKQQRRELL--FNEVVIMR---DYHHDNVV 105 Query: 78 RLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLH 137 ++ V +L +V E ++ T D V + E I + +LR L +LH Sbjct: 106 DMYSSYLVG-----DELWVVMEFLEGGALT--DIVTHTRMNEEQIATVCLSVLRALSYLH 158 Query: 138 SHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQM-ALTSVVVTLWYRAPEVLLQSSY 196 + V+HRD+K +IL+TS G+IKL+DFG S ++ S+V T ++ APEV+ + Y Sbjct: 159 NQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPY 218 Query: 197 ATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHS 256 T VD+WS+G + EM +P + + + +I RD PR Sbjct: 219 GTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRI-------------RDSLPPRVKDLH 265 Query: 257 KSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQ 301 K + + F+ DL+ L P++R +A L HP+ + Sbjct: 266 KVSSVLRGFL--------DLM---LVREPSQRATAQELLGHPFLK 299 >2XIK-A nrPDB Length = 294 Score = 98.2 bits (243), Expect = 4e-21, Method: Compositional matrix adjust. Identities = 85/283 (30%), Positives = 149/283 (52%), Gaps = 41/283 (14%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVR 78 IG+G++G+V+K D + VA+K + ++ E+ + +E+ VL ++ P + R Sbjct: 27 IGKGSFGEVYKGID-NHTKEVVAIKIIDLEEAEDEIEDIQ-QEITVLSQCDS---PYITR 81 Query: 79 LFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTET-IKDMMFQLLRGLDFLH 137 F S TKL ++ E++ + LD + +PG ET I ++ ++L+GLD+LH Sbjct: 82 YFGSYLKS-----TKLWIIMEYLGGG--SALDLL-KPGPLEETYIATILREILKGLDYLH 133 Query: 138 SHRVVHRDLKPQNILVTSSGQIKLADFGLA-RIYSFQMALTSVVVTLWYRAPEVLLQSSY 196 S R +HRD+K N+L++ G +KLADFG+A ++ Q+ + V T ++ APEV+ QS+Y Sbjct: 134 SERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAY 193 Query: 197 ATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHS 256 D+WS+G E+ + +P +SD+ + ++L +I P++ + HS Sbjct: 194 DFKADIWSLGITAIELAKGEP---PNSDLHPM-RVLFLI--------PKNSPPTLEGQHS 241 Query: 257 KSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPY 299 K P ++FV CL +P R +A L H + Sbjct: 242 K---PFKEFVE-----------ACLNKDPRFRPTAKELLKHKF 270 >3H4J-B nrPDB Length = 336 Score = 97.8 bits (242), Expect = 5e-21, Method: Compositional matrix adjust. Identities = 63/197 (31%), Positives = 109/197 (55%), Gaps = 13/197 (6%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEG-MPLSTIREVAVLRHLETFEHPNVV 77 +GEG++GKV A K + VALK + Q ++ M + RE++ +L+ HP+++ Sbjct: 17 LGEGSFGKVKLATHYKTQQK-VALKFISRQLLKKSDMHMRVEREIS---YLKLLRHPHII 72 Query: 78 RLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLH 137 +L+DV T T + +V E+ +L Y+ V + + + + Q++ +++ H Sbjct: 73 KLYDVITTP-----TDIVMVIEYAGGELFDYI--VEKKRMTEDEGRRFFQQIICAIEYCH 125 Query: 138 SHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYA 197 H++VHRDLKP+N+L+ + +K+ADFGL+ I + L + + Y APEV+ YA Sbjct: 126 RHKIVHRDLKPENLLLDDNLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVINGKLYA 185 Query: 198 TP-VDLWSVGCIFAEMF 213 P VD+WS G + M Sbjct: 186 GPEVDVWSCGIVLYVML 202 >4APC-A nrPDB Length = 350 Score = 97.8 bits (242), Expect = 6e-21, Method: Compositional matrix adjust. Identities = 60/225 (26%), Positives = 114/225 (50%), Gaps = 11/225 (4%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 ++Y + +IGEG++GK + ++G ++V +K + + + REVAVL +++ Sbjct: 24 EKYVRLQKIGEGSFGKAILVKSTEDGRQYV-IKEINISRMSSKEREESRREVAVLANMK- 81 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQL 129 HPN+V+ + + L +V ++ + DL ++ + I D Q+ Sbjct: 82 --HPNIVQYRE-----SFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQI 134 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVV-TLWYRAP 188 L +H +++HRD+K QNI +T G ++L DFG+AR+ + + L + T +Y +P Sbjct: 135 CLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARACIGTPYYLSP 194 Query: 189 EVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILD 233 E+ Y D+W++GC+ E+ K F S + + KI+ Sbjct: 195 EICENKPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIIS 239 >2X4F-A nrPDB Length = 373 Score = 97.1 bits (240), Expect = 9e-21, Method: Compositional matrix adjust. Identities = 84/290 (28%), Positives = 131/290 (45%), Gaps = 44/290 (15%) Query: 19 IGEGAYGKVFKARDLKNGGRFVA--LKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNV 76 +G G +G+V K + G + A +K ++ EE E++V+ L+ H N+ Sbjct: 97 LGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKEE-----VKNEISVMNQLD---HANL 148 Query: 77 VRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMF--QLLRGLD 134 ++L+D S+ D + LV E+VD D++ + + ++F Q+ G+ Sbjct: 149 IQLYDAFE-SKND----IVLVMEYVDG--GELFDRIIDESYNLTELDTILFMKQICEGIR 201 Query: 135 FLHSHRVVHRDLKPQNILVTS--SGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLL 192 +H ++H DLKP+NIL + + QIK+ DFGLAR Y + L T + APEV+ Sbjct: 202 HMHQMYILHLDLKPENILCVNRDAKQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVN 261 Query: 193 QSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQ 252 + P D+WSVG I + F G +D + L IL W L + Sbjct: 262 YDFVSFPTDMWSVGVIAYMLLSGLSPFLGDNDAETLNNILAC-------RWD----LEDE 310 Query: 253 AFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQD 302 F DI E K+ + K L + RISA AL HP+ D Sbjct: 311 EFQ------------DISEEAKEFISKLLIKEKSWRISASEALKHPWLSD 348 >2V7O-A nrPDB Length = 336 Score = 97.1 bits (240), Expect = 9e-21, Method: Compositional matrix adjust. Identities = 93/307 (30%), Positives = 133/307 (43%), Gaps = 59/307 (19%) Query: 8 RADQQYECVAEIGEGAYGKVF----KARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVA 63 R Y+ E+G+GA+ V K + + + K++ + ++ RE Sbjct: 28 RFTDDYQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSARDHQK-----LEREAR 82 Query: 64 VLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTT----YLDKVPEPGVPT 119 + R L+ HPN+VRL D + E LVF DL T + D V Sbjct: 83 ICRLLK---HPNIVRLHDSIS-----EEGFHYLVF-----DLVTGGELFEDIVAREYYSE 129 Query: 120 ETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTS---SGQIKLADFGLA-RIYSFQMA 175 + Q+L ++ +H H +VHRDLKP+N+L+ S +KLADFGLA + Q A Sbjct: 130 ADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQA 189 Query: 176 LTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVI 235 T Y +PEVL + Y PVD+W+ G I + P F D DQ K+ I Sbjct: 190 WFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFW---DEDQ-HKLYQQI 245 Query: 236 GLPGEEDWPR---DVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAY 292 G D+P D P K+L+ + LT NPAKRI+A Sbjct: 246 K-AGAYDFPSPEWDTVTPE---------------------AKNLINQMLTINPAKRITAD 283 Query: 293 SALSHPY 299 AL HP+ Sbjct: 284 QALKHPW 290 >4JXF-A nrPDB Length = 266 Score = 97.1 bits (240), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 80/285 (28%), Positives = 139/285 (48%), Gaps = 40/285 (14%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRV-RVQTGEEGMPLSTIREVAVLRHLETFEHPNVV 77 +G+G++ V++A + G VA+K + + + GM EV + H + +HP+++ Sbjct: 15 LGKGSFAGVYRAESIHTGLE-VAIKMIDKKAMYKAGMVQRVQNEVKI--HCQ-LKHPSIL 70 Query: 78 RLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFL 136 L++ + + LV E + ++ YL +P E + M Q++ G+ +L Sbjct: 71 ELYNY-----FEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEA-RHFMHQIITGMLYL 124 Query: 137 HSHRVVHRDLKPQNILVTSSGQIKLADFGLA-RIYSFQMALTSVVVTLWYRAPEVLLQSS 195 HSH ++HRDL N+L+T + IK+ADFGLA ++ ++ T Y +PE+ +S+ Sbjct: 125 HSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSA 184 Query: 196 YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFH 255 + D+WS+GC+F + +P F D D + L+ + L D +P +F Sbjct: 185 HGLESDVWSLGCMFYTLLIGRPPF----DTDTVKNTLNKVVLA-------DYEMP--SFL 231 Query: 256 SKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 S A KDL+ + L NPA R+S S L HP+ Sbjct: 232 SIEA--------------KDLIHQLLRRNPADRLSLSSVLDHPFM 262 >3SOA-A nrPDB Length = 444 Score = 96.7 bits (239), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 93/305 (30%), Positives = 132/305 (43%), Gaps = 53/305 (17%) Query: 8 RADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALK-RVRVQTGEEGMPLSTIREVAVLR 66 R ++Y+ E+G+GA+ V + + G + A+ + + + L RE + R Sbjct: 8 RFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDHQKLE--REARICR 65 Query: 67 HLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTT----YLDKVPEPGVPTETI 122 L+ HPN+VRL D + E L+F DL T + D V Sbjct: 66 LLK---HPNIVRLHDSIS-----EEGHHYLIF-----DLVTGGELFEDIVAREYYSEADA 112 Query: 123 KDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTS---SGQIKLADFGLA-RIYSFQMALTS 178 + Q+L + H VVHR+LKP+N+L+ S +KLADFGLA + Q A Sbjct: 113 SHCIQQILEAVLHCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFG 172 Query: 179 VVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLP 238 T Y +PEVL + Y PVDLW+ G I + P F D DQ ++ I Sbjct: 173 FAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPF---WDEDQ-HRLYQQIK-A 227 Query: 239 GEEDWPR---DVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSAL 295 G D+P D P KDL+ K LT NP+KRI+A AL Sbjct: 228 GAYDFPSPEWDTVTPE---------------------AKDLINKMLTINPSKRITAAEAL 266 Query: 296 SHPYF 300 HP+ Sbjct: 267 KHPWI 271 >2YAB-A nrPDB Length = 361 Score = 96.3 bits (238), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 81/295 (27%), Positives = 132/295 (44%), Gaps = 41/295 (13%) Query: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVA--LKRVRVQTGEEGMPLSTI-REVAVLRHLE 69 Y+ E+G G + V K R+ G + A +K+ + + G+ I REV++LR + Sbjct: 14 YDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIEREVSILRQVL 73 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQ 128 HPN++ L DV +RTD + L+ E V +L +L + + + E + Q Sbjct: 74 ---HPNIITLHDVYE-NRTD----VVLILELVSGGELFDFLAQ--KESLSEEEATSFIKQ 123 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSG----QIKLADFGLARIYSFQMALTSVVVTLW 184 +L G+++LH+ ++ H DLKP+NI++ IKL DFGLA + ++ T Sbjct: 124 ILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPE 183 Query: 185 YRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWP 244 + APE++ D+WS+G I + F G + + L I V Sbjct: 184 FVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAV---------- 233 Query: 245 RDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPY 299 S E+F + EL KD + K L KR++ AL HP+ Sbjct: 234 -------------SYDFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPW 275 >5U6Y-A nrPDB Length = 461 Score = 96.3 bits (238), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 93/300 (31%), Positives = 129/300 (43%), Gaps = 53/300 (17%) Query: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVA-LKRVRVQTGEEGMPLSTIREVAVLRHLETF 71 Y+ E+G+GA+ V + + G + A + + + + L RE + R L+ Sbjct: 2 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLE--REARICRLLK-- 57 Query: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTT----YLDKVPEPGVPTETIKDMMF 127 HPN+VRL D + E L+F DL T + D V + Sbjct: 58 -HPNIVRLHDSIS-----EEGHHYLIF-----DLVTGGELFEDIVAREYYSEADASHCIQ 106 Query: 128 QLLRGLDFLHSHRVVHRDLKPQNILVTS---SGQIKLADFGLA-RIYSFQMALTSVVVTL 183 Q+L + H VVHRDLKP+N+L+ S +KLADFGLA + Q A T Sbjct: 107 QILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTP 166 Query: 184 WYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDW 243 Y +PEVL + Y PVDLW+ G I + P F D DQ ++ I G D+ Sbjct: 167 GYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFW---DEDQ-HRLYQQIK-AGAYDF 221 Query: 244 PR---DVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 P D P KDL+ K LT NP+KRI+A AL HP+ Sbjct: 222 PSPEWDTVTPE---------------------AKDLINKMLTINPSKRITAAEALKHPWI 260 >2JAM-A nrPDB Length = 304 Score = 96.3 bits (238), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 80/285 (28%), Positives = 132/285 (46%), Gaps = 41/285 (14%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVR 78 +G GA+ +VF + + G+ ALK ++ L E+AVL+ ++ H N+V Sbjct: 17 LGSGAFSEVFLVKQ-RLTGKLFALKCIKKSPAFRDSSLEN--EIAVLKKIK---HENIVT 70 Query: 79 LFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQ-LLRGLDFLH 137 L D+ + T LV + V D++ E GV TE ++ Q +L + +LH Sbjct: 71 LEDI-----YESTTHYYLVMQLVSGG--ELFDRILERGVYTEKDASLVIQQVLSAVKYLH 123 Query: 138 SHRVVHRDLKPQNILVTS---SGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQS 194 + +VHRDLKP+N+L + + +I + DFGL+++ +++ T Y APEVL Q Sbjct: 124 ENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQ-NGIMSTACGTPGYVAPEVLAQK 182 Query: 195 SYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAF 254 Y+ VD WS+G I + P F ++ KI ++ + Sbjct: 183 PYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKI-------------------KEGY 223 Query: 255 HSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPY 299 + + F DI E KD + L +P +R + ALSHP+ Sbjct: 224 YEFES----PFWDDISESAKDFICHLLEKDPNERYTCEKALSHPW 264 >4CZT-A nrPDB Length = 464 Score = 95.9 bits (237), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 68/204 (33%), Positives = 106/204 (51%), Gaps = 17/204 (8%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRV-RVQTGEEGMPLSTIREVAVLRHLET 70 +YE +GEG + KV AR+++NG VA+K + + + + M RE++ ++ ++ Sbjct: 12 KYELGRTLGEGTFAKVKFARNVENGDN-VAIKVIDKEKVLKNKMIAQIKREISTMKLIK- 69 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQ-L 129 HPNV+R+F+V +TK+ V E V DK+ G E FQ L Sbjct: 70 --HPNVIRMFEVMA-----SKTKIYFVLEFVTGG--ELFDKISSNGRLKEDEARKYFQQL 120 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARI---YSFQMALTSVVVTLWYR 186 + +D+ HS V HRDLKP+N+L+ ++G +K++DFGL+ + L + T Y Sbjct: 121 INAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYV 180 Query: 187 APEVLLQSSY-ATPVDLWSVGCIF 209 APEV+ Y DLWS G I Sbjct: 181 APEVINNKGYDGAKADLWSCGVIL 204 >2X7G-A nrPDB Length = 389 Score = 95.9 bits (237), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 95/369 (25%), Positives = 155/369 (42%), Gaps = 87/369 (23%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLE 69 + +Y + ++G G + V+ D++ G RFVA+K V+ L I+ + +R + Sbjct: 30 NGRYHVIRKLGWGHFSTVWLCWDMQ-GKRFVAMKVVKSAQHYTETALDEIKLLKCVRESD 88 Query: 70 TFEHPN---VVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMM 126 + PN VV+L D +S + + +VFE + L ++ K G+P +K ++ Sbjct: 89 PSD-PNKDMVVQLIDDFKISGMN-GIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSII 146 Query: 127 FQLLRGLDFLHSH-RVVHRDLKPQNILVT-----------------------SSG----- 157 Q+L+GLD+LHS +++H D+KP+NIL+ SG Sbjct: 147 RQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAVST 206 Query: 158 -------------------QIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYAT 198 ++K+AD G A T + T YR+ EVL+ + Y+T Sbjct: 207 APAADLLVNPLDPRNADKIRVKIADLGNA--CWVHKHFTEDIQTRQYRSIEVLIGAGYST 264 Query: 199 PVDLWSVGCIFAEMFRRKPLFRGSS------DVDQLGKILDVIGLPGEEDWPRDVAL--- 249 P D+WS C+ E+ LF S D D + I++++G PR AL Sbjct: 265 PADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLG-----SIPRHFALSGK 319 Query: 250 -PRQAF-------HSKSAQPIEKFVTDIDELG---------KDLLLKCLTFNPAKRISAY 292 R+ F H +P F +++ G D L+ L P KR SA Sbjct: 320 YSREFFNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAG 379 Query: 293 SALSHPYFQ 301 L HP+ Sbjct: 380 ECLRHPWLN 388 >2VZ6-A nrPDB Length = 313 Score = 95.9 bits (237), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 91/296 (30%), Positives = 128/296 (43%), Gaps = 45/296 (15%) Query: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVA-LKRVRVQTGEEGMPLSTIREVAVLRHLETF 71 Y+ E+G+GA+ V + + G + A + + + + L RE + R L+ Sbjct: 24 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLE--REARICRLLK-- 79 Query: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLR 131 HPN+VRL D + E L+F+ V + D V + Q+L Sbjct: 80 -HPNIVRLHDSIS-----EEGHHYLIFDLVTGG-ELFEDIVAREYYSEADASHCIQQILE 132 Query: 132 GLDFLHSHRVVHRDLKPQNILVTS---SGQIKLADFGLA-RIYSFQMALTSVVVTLWYRA 187 + H VVHRDLKP+N+L+ S +KLADFGLA + Q A T Y + Sbjct: 133 AVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLS 192 Query: 188 PEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPR-- 245 PEVL + Y PVDLW+ G I + P F D DQ ++ I G D+P Sbjct: 193 PEVLRKDPYGKPVDLWACGVILYILLVGYPPFW---DEDQ-HRLYQQIK-AGAYDFPSPE 247 Query: 246 -DVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 D P KDL+ K LT NP+KRI+A AL HP+ Sbjct: 248 WDTVTPE---------------------AKDLINKMLTINPSKRITAAEALKHPWI 282 >3BHH-A nrPDB Length = 295 Score = 95.5 bits (236), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 93/300 (31%), Positives = 130/300 (43%), Gaps = 53/300 (17%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVA-LKRVRVQTGEEGMPLSTIREVAVLRHLET 70 +Y+ +IG+GA+ V + L G + A + + + + L RE + R L+ Sbjct: 5 EYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLE--REARICRLLK- 61 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTT----YLDKVPEPGVPTETIKDMM 126 H N+VRL D E LVF DL T + D V + Sbjct: 62 --HSNIVRLHD-----SISEEGFHYLVF-----DLVTGGELFEDIVAREYYSEADASHCI 109 Query: 127 FQLLRGLDFLHSHRVVHRDLKPQNILVTS---SGQIKLADFGLA-RIYSFQMALTSVVVT 182 Q+L + H VVHRDLKP+N+L+ S +KLADFGLA + Q A T Sbjct: 110 QQILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGT 169 Query: 183 LWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEED 242 Y +PEVL + +Y PVD+W+ G I + P F D DQ K+ I G D Sbjct: 170 PGYLSPEVLRKEAYGKPVDIWACGVILYILLVGYPPF---WDEDQ-HKLYQQIK-AGAYD 224 Query: 243 WPR---DVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPY 299 +P D P K+L+ + LT NPAKRI+A+ AL HP+ Sbjct: 225 FPSPEWDTVTPE---------------------AKNLINQMLTINPAKRITAHEALKHPW 263 >5FG8-A nrPDB Length = 285 Score = 95.5 bits (236), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 94/310 (30%), Positives = 129/310 (41%), Gaps = 53/310 (17%) Query: 8 RADQQYECVAEIGEGAYGKVFKARDLKNGGRFVA-LKRVRVQTGEEGMPLSTIREVAVLR 66 R Y+ E+G+GA+ V + G F A + + T + L RE + R Sbjct: 11 RFSDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLE--REARICR 68 Query: 67 HLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTT----YLDKVPEPGVPTETI 122 L HPN+VRL D E LVF DL T + D V Sbjct: 69 KLH---HPNIVRLHD-----SIQEENYHYLVF-----DLVTGGELFEDIVAREFYSEADA 115 Query: 123 KDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQ---IKLADFGLA-RIYSFQMALTS 178 + Q+L ++ H + VVHRDLKP+N+L+ S + +KLADFGLA + A Sbjct: 116 SHCIQQILESVNHCHQNGVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFG 175 Query: 179 VVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLP 238 T Y +PEVL + Y VD+W+ G I + P F D DQ ++ I Sbjct: 176 FAGTPGYLSPEVLKKEPYGKSVDIWACGVILYILLVGYPPFW---DEDQ-HRLYSQIK-A 230 Query: 239 GEEDWPR---DVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSAL 295 G D+P D P K+L+ + LT NP KRI+A AL Sbjct: 231 GAYDYPSPEWDTVTPE---------------------AKNLINQMLTVNPNKRITAAEAL 269 Query: 296 SHPYFQDLER 305 HP+ ER Sbjct: 270 KHPWICQRER 279 >3ORZ-A nrPDB Length = 316 Score = 95.5 bits (236), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 88/309 (28%), Positives = 141/309 (45%), Gaps = 51/309 (16%) Query: 19 IGEGAYGKVFKARDLKNGGRF-VALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVV 77 +GEG++ V AR+L + + + R E +P T RE V+ L+ HP V Sbjct: 45 LGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVT-RERDVMSRLD---HPFFV 100 Query: 78 RLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTET-IKDMMFQLLRGLDFL 136 +L+ C + D + L + + +L Y+ K+ G ET + +++ L++L Sbjct: 101 KLY-FCF--QDDEKLYFGLSYAK-NGELLKYIRKI---GSFDETCTRFYTAEIVSALEYL 153 Query: 137 HSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY---SFQMALTSVVVTLWYRAPEVLLQ 193 H ++HRDLKP+NIL+ I++ DFG A++ S Q S V T Y +PE+L + Sbjct: 154 HGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTE 213 Query: 194 SSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQA 253 S DLW++GCI ++ P FR ++ KI+ + E D+P Sbjct: 214 KSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKL-----EYDFP--------- 259 Query: 254 FHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRIS-----AYSAL-SHPYFQDLERCK 307 EKF +DL+ K L + KR+ Y L +HP+F+ + Sbjct: 260 ---------EKFFPK----ARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESV--TW 304 Query: 308 ENLDSHLPP 316 ENL PP Sbjct: 305 ENLHQQTPP 313 >2Z7Q-A nrPDB Length = 321 Score = 95.5 bits (236), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 78/242 (32%), Positives = 120/242 (49%), Gaps = 16/242 (6%) Query: 3 KDGLCRAD-QQYECVAEIGEGAYGKVFKARDLK--NGGRFVALKRVRVQTGEEGMPLSTI 59 K G +AD +E + +G+G++GKVF R + + G A+K ++ T + + T Sbjct: 19 KAGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTK 78 Query: 60 REVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPGVP 118 E +L + HP VV+L E KL L+ + + DL T L K E Sbjct: 79 MERDILADVN---HPFVVKLHYAFQT-----EGKLYLILDFLRGGDLFTRLSK--EVMFT 128 Query: 119 TETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLAR-IYSFQMALT 177 E +K + +L GLD LHS +++RDLKP+NIL+ G IKL DFGL++ + Sbjct: 129 EEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAY 188 Query: 178 SVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDV-IG 236 S T+ Y APEV+ + ++ D WS G + EM F+G + + IL +G Sbjct: 189 SFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLG 248 Query: 237 LP 238 +P Sbjct: 249 MP 250 >6CMJ-A nrPDB Length = 321 Score = 94.7 bits (234), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 93/310 (30%), Positives = 145/310 (46%), Gaps = 55/310 (17%) Query: 7 CRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALK-----RVRVQTGEEGMPLSTI-- 59 C QY EIG+G+YG V A + +N + A+K ++ Q G P I Sbjct: 30 CVQLDQYTLKDEIGKGSYGVVKLAYN-ENDNTYYAMKVLSKKKLIRQAGGCIQPRGPIEQ 88 Query: 60 --REVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGV 117 +E+A+L+ L+ HPNVV+L +V D L +VFE V+Q +VP Sbjct: 89 VYQEIAILKKLD---HPNVVKLVEVLDDPNEDH---LYMVFELVNQGPVM---EVPTLKP 139 Query: 118 PTETIKDMMFQ-LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMAL 176 +E FQ L++G+++LH +++HRD+KP N+LV G IK+ADFG++ + AL Sbjct: 140 LSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDAL 199 Query: 177 TSVVV-TLWYRAPEVLLQSS---YATPVDLWSVGC-IFAEMFRRKPLFRGSSDVDQLGKI 231 S V T + APE L ++ +D+W++G ++ +F + P +D+ +I Sbjct: 200 LSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPF------MDE--RI 251 Query: 232 LDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKF--VTDIDELGKDLLLKCLTFNPAKRI 289 + HSK +F DI E KDL+ + L NP RI Sbjct: 252 M--------------------CLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRI 291 Query: 290 SAYSALSHPY 299 HP+ Sbjct: 292 VVPEIKLHPW 301 >6FDY-U nrPDB Length = 276 Score = 94.0 bits (232), Expect = 8e-20, Method: Compositional matrix adjust. Identities = 86/291 (29%), Positives = 133/291 (45%), Gaps = 42/291 (14%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVR 78 +G G Y V+KA K+ VA+K V ++ + + + E+ +L+ + HP++V+ Sbjct: 19 LGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKGIR---HPHIVQ 75 Query: 79 LFDVCTVSRTDRETKLTLVFEH-VDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLH 137 L D S + L+ E DL+ ++ +P + + M QL L FLH Sbjct: 76 LKDFQWDS-----DNIYLIMEFCAGGDLSRFIHT--RRILPEKVARVFMQQLASALQFLH 128 Query: 138 SHRVVHRDLKPQNILVTS--SGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSS 195 + H DLKPQNIL++S +KLADFG A+ S + + Y APE++ Q Sbjct: 129 ERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMVCQRQ 188 Query: 196 YATPVDLWSVGCIFAEMFRRKPLF--RGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQA 253 Y VDLWS+G I E +P F R S++++ + VI LP RD Sbjct: 189 YDARVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRPLLSRDC------ 242 Query: 254 FHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLE 304 +DLL + L +P++RIS +HP+ DLE Sbjct: 243 --------------------RDLLQRLLERDPSRRISFQDFFAHPWV-DLE 272 >1ZWS-A nrPDB Length = 288 Score = 94.0 bits (232), Expect = 8e-20, Method: Compositional matrix adjust. Identities = 81/295 (27%), Positives = 131/295 (44%), Gaps = 41/295 (13%) Query: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVA--LKRVRVQTGEEGMPLSTI-REVAVLRHLE 69 Y+ E+G G + V K R+ G + A +K+ + + G+ I REV++LR + Sbjct: 14 YDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVL 73 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQ 128 H NV+ L DV +RTD + L+ E V +L +L + + + E + Q Sbjct: 74 ---HHNVITLHDVYE-NRTD----VVLILELVSGGELFDFLAQ--KESLSEEEATSFIKQ 123 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSG----QIKLADFGLARIYSFQMALTSVVVTLW 184 +L G+++LH+ ++ H DLKP+NI++ IKL DFGLA + ++ T Sbjct: 124 ILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPE 183 Query: 185 YRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWP 244 + APE++ D+WS+G I + F G + + L I V Sbjct: 184 FVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITSV---------- 233 Query: 245 RDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPY 299 S E+F + EL KD + K L KR++ AL HP+ Sbjct: 234 -------------SYDFDEEFFSHTSELAKDFIRKLLVKETRKRLTIQEALRHPW 275 >3D2K-A nrPDB Length = 272 Score = 94.0 bits (232), Expect = 8e-20, Method: Compositional matrix adjust. Identities = 75/285 (26%), Positives = 135/285 (47%), Gaps = 41/285 (14%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRV--RVQTGEEGMPLSTIREVAVLRHLETFEHPNV 76 +G+G +G V+ AR+ ++ +F+ +V + Q + G+ REV + HL HPN+ Sbjct: 20 LGKGKFGNVYLARERQS--KFILALKVLFKTQLEKAGVEHQLRREVEIQSHLR---HPNI 74 Query: 77 VRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFL 136 +RL+ + T++ L+ E+ T Y + + + +L L + Sbjct: 75 LRLYGYFHDA-----TRVYLILEYAPLG-TVYRELQKLSRFDEQRTATYITELANALSYC 128 Query: 137 HSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSY 196 HS RV+HRD+KP+N+L+ S+G++K+ADFG + +++ T++ TL Y PE++ + Sbjct: 129 HSKRVIHRDIKPENLLLGSNGELKIADFGWS-VHAPSSRRTTLCGTLDYLPPEMIEGRMH 187 Query: 197 ATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHS 256 VDLWS+G + E P F + + +I V + P Sbjct: 188 DEKVDLWSLGVLCYEFLVGMPPFEAHTYQETYRRISRV-----------EFTFP------ 230 Query: 257 KSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQ 301 FVT E +DL+ + L N ++R++ L HP+ + Sbjct: 231 -------DFVT---EGARDLISRLLKHNASQRLTLAEVLEHPWIK 265 >2JC6-A nrPDB Length = 334 Score = 94.0 bits (232), Expect = 8e-20, Method: Compositional matrix adjust. Identities = 83/292 (28%), Positives = 131/292 (44%), Gaps = 39/292 (13%) Query: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 +E +G GA+ +V A + K G+ A+K + + +G S E+AVLR ++ Sbjct: 24 FEFKETLGTGAFSEVVLAEE-KATGKLFAVKCIP-KKALKGKESSIENEIAVLRKIK--- 78 Query: 73 HPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTET-IKDMMFQLLR 131 H N+V L D+ + L LV + V D++ E G TE ++ Q+L Sbjct: 79 HENIVALEDI-----YESPNHLYLVMQLVSG--GELFDRIVEKGFYTEKDASTLIRQVLD 131 Query: 132 GLDFLHSHRVVHRDLKPQNILVTSS---GQIKLADFGLARIYSFQMALTSVVVTLWYRAP 188 + +LH +VHRDLKP+N+L S +I ++DFGL+++ +++ T Y AP Sbjct: 132 AVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAP 191 Query: 189 EVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA 248 EVL Q Y+ VD WS+G I + P F +D +IL E D P Sbjct: 192 EVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKA---EYEFDSP---- 244 Query: 249 LPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 + DI + KD + + +P KR + A HP+ Sbjct: 245 ----------------YWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWI 280 >4WUA-A nrPDB Length = 401 Score = 94.0 bits (232), Expect = 8e-20, Method: Compositional matrix adjust. Identities = 94/371 (25%), Positives = 158/371 (42%), Gaps = 89/371 (23%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLE 69 + +Y + ++G G + V+ + D++ G +FVA+K V+ L IR + +R+ + Sbjct: 40 NGRYHVIRKLGWGHFSTVWLSWDIQ-GKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSD 98 Query: 70 TFEHPN---VVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMM 126 + PN VV+L D +S + T + +VFE + L ++ K G+P +K ++ Sbjct: 99 PND-PNREMVVQLLDDFKISGVNG-THICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKII 156 Query: 127 FQLLRGLDFLHSH-RVVHRDLKPQNILVTSSGQ--------------------------- 158 Q+L+GLD+LH+ R++H D+KP+NIL++ + Q Sbjct: 157 QQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVST 216 Query: 159 ----------------------IKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSY 196 +K+AD G A T + T YR+ EVL+ S Y Sbjct: 217 APATAGNFLVNPLEPKNAEKLKVKIADLGNA--CWVHKHFTEDIQTRQYRSLEVLIGSGY 274 Query: 197 ATPVDLWSVGCIFAEMFRRKPLFRGSS------DVDQLGKILDVIGLPGEEDWPRDVALP 250 TP D+WS C+ E+ LF S D D + I++++G PR + + Sbjct: 275 NTPADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKV-----PRKLIVA 329 Query: 251 ----RQAF-------HSKSAQP-------IEKFVTDIDELG--KDLLLKCLTFNPAKRIS 290 ++ F H +P +EK+ +E D LL L P KR + Sbjct: 330 GKYSKEFFTKKGDLKHITKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRAT 389 Query: 291 AYSALSHPYFQ 301 A L HP+ Sbjct: 390 AAECLRHPWLN 400 >2A27-A nrPDB Length = 321 Score = 93.6 bits (231), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 81/295 (27%), Positives = 131/295 (44%), Gaps = 41/295 (13%) Query: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVA--LKRVRVQTGEEGMPLSTI-REVAVLRHLE 69 Y+ E+G G + V K R+ G + A +K+ + + G+ I REV++LR + Sbjct: 14 YDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVL 73 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQ 128 H NV+ L DV +RTD + L+ E V +L +L + + + E + Q Sbjct: 74 ---HHNVITLHDVYE-NRTD----VVLILELVSGGELFDFLAQ--KESLSEEEATSFIKQ 123 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSG----QIKLADFGLARIYSFQMALTSVVVTLW 184 +L G+++LH+ ++ H DLKP+NI++ IKL DFGLA + ++ T Sbjct: 124 ILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPE 183 Query: 185 YRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWP 244 + APE++ D+WS+G I + F G + + L I V Sbjct: 184 FVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAV---------- 233 Query: 245 RDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPY 299 S E+F + EL KD + K L KR++ AL HP+ Sbjct: 234 -------------SYDFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPW 275 >4B8L-A nrPDB Length = 286 Score = 93.6 bits (231), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 72/285 (25%), Positives = 136/285 (47%), Gaps = 41/285 (14%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRV--RVQTGEEGMPLSTIREVAVLRHLETFEHPNV 76 +G+G +G V+ AR+ +N +F+ +V + Q +EG+ RE+ + HL HPN+ Sbjct: 23 LGKGKFGNVYLAREKQN--KFIMALKVLFKSQLEKEGVEHQLRREIEIQSHLR---HPNI 77 Query: 77 VRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFL 136 +R+++ DR+ ++ L+ E + Y + + M +L L + Sbjct: 78 LRMYNYFH----DRK-RIYLMLEFAPRG-ELYKELQKHGRFDEQRSATFMEELADALHYC 131 Query: 137 HSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSY 196 H +V+HRD+KP+N+L+ G++K+ADFG + +++ + ++ TL Y PE++ ++ Sbjct: 132 HERKVIHRDIKPENLLMGYKGELKIADFGWS-VHAPSLRRRTMCGTLDYLPPEMIEGKTH 190 Query: 197 ATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHS 256 VDLW G + E P F S + +I++V D+ P Sbjct: 191 DEKVDLWCAGVLCYEFLVGMPPFDSPSHTETHRRIVNV-----------DLKFP------ 233 Query: 257 KSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQ 301 F++D KDL+ K L ++P +R+ + HP+ + Sbjct: 234 -------PFLSDG---SKDLISKLLRYHPPQRLPLKGVMEHPWVK 268 >6E2O-A nrPDB Length = 295 Score = 92.8 bits (229), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 69/208 (33%), Positives = 104/208 (50%), Gaps = 19/208 (9%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVR 78 +G+G YG V+ RDL N R +A+K + + PL E+A+ +HL +H N+V+ Sbjct: 30 LGKGTYGIVYAGRDLSNQVR-IAIKEIPERDSRYSQPLH--EEIALHKHL---KHKNIVQ 83 Query: 79 LFDVCTVSRTDRETKLTLVF-EHV-DQDLTTYLDKVPEPGVPTE-TIKDMMFQLLRGLDF 135 + E +F E V L+ L P E TI Q+L GL + Sbjct: 84 YLGSFS------ENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKY 137 Query: 136 LHSHRVVHRDLKPQNILV-TSSGQIKLADFGLA-RIYSFQMALTSVVVTLWYRAPEVLLQ 193 LH +++VHRD+K N+L+ T SG +K++DFG + R+ + TL Y APE++ + Sbjct: 138 LHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDK 197 Query: 194 S--SYATPVDLWSVGCIFAEMFRRKPLF 219 Y D+WS+GC EM KP F Sbjct: 198 GPRGYGKAADIWSLGCTIIEMATGKPPF 225 >3KK8-A nrPDB Length = 284 Score = 92.8 bits (229), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 90/305 (29%), Positives = 129/305 (42%), Gaps = 52/305 (17%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVA-LKRVRVQTGEEGMPLSTIREVAVLRHLET 70 Y+ E+G+GA+ V + G F A + + + + L RE + R L+ Sbjct: 7 NYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLE--REARICRKLQ- 63 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTT----YLDKVPEPGVPTETIKDMM 126 HPN+VRL D E+ LVF DL T + D V + Sbjct: 64 --HPNIVRLHD-----SIQEESFHYLVF-----DLVTGGELFEDIVAREFYSEADASHCI 111 Query: 127 FQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQ---IKLADFGLARIYSFQMALTSVVVTL 183 Q+L + + HS+ +VHR+LKP+N+L+ S + +KLADFGLA + A T Sbjct: 112 QQILESIAYCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTP 171 Query: 184 WYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDW 243 Y +PEVL + Y+ PVD+W+ G I + P F D DQ + G D+ Sbjct: 172 GYLSPEVLKKDPYSKPVDIWACGVILYILLVGYPPFW---DEDQHRLYAQIKA--GAYDY 226 Query: 244 PR---DVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 P D P K L+ LT NP KRI+A AL P+ Sbjct: 227 PSPEWDTVTPE---------------------AKSLIDSMLTVNPKKRITADQALKVPWI 265 Query: 301 QDLER 305 + ER Sbjct: 266 CNRER 270 >4XBR-A nrPDB Length = 366 Score = 92.8 bits (229), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 78/284 (27%), Positives = 136/284 (47%), Gaps = 38/284 (13%) Query: 18 EIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVV 77 +IGEG+ G V A +++ G+ VA+K++ ++ + L EV ++R ++H NVV Sbjct: 101 KIGEGSTGIVCIA-TVRSSGKLVAVKKMDLRKQQRRELL--FNEVVIMR---DYQHENVV 154 Query: 78 RLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLH 137 +++ V +L +V E ++ T D V + E I + +L+ L LH Sbjct: 155 EMYNSYLVG-----DELWVVMEFLEGGALT--DIVTHTRMNEEQIAAVCLAVLQALSVLH 207 Query: 138 SHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMA-LTSVVVTLWYRAPEVLLQSSY 196 + V+HRD+K +IL+T G++KL+DFG S ++ S+V T ++ APE++ + Y Sbjct: 208 AQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPY 267 Query: 197 ATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHS 256 VD+WS+G + EM +P + + + I RD PR Sbjct: 268 GPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMI-------------RDNLPPRLKNLH 314 Query: 257 KSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 K + ++ F L + L +PA+R +A L HP+ Sbjct: 315 KVSPSLKGF-----------LDRLLVRDPAQRATAAELLKHPFL 347 >2BDW-A nrPDB Length = 362 Score = 92.4 bits (228), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 90/305 (29%), Positives = 129/305 (42%), Gaps = 52/305 (17%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVA-LKRVRVQTGEEGMPLSTIREVAVLRHLET 70 Y+ E+G+GA+ V + G F A + + + + L RE + R L+ Sbjct: 30 NYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLE--REARICRKLQ- 86 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTT----YLDKVPEPGVPTETIKDMM 126 HPN+VRL D E+ LVF DL T + D V + Sbjct: 87 --HPNIVRLHD-----SIQEESFHYLVF-----DLVTGGELFEDIVAREFYSEADASHCI 134 Query: 127 FQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQ---IKLADFGLARIYSFQMALTSVVVTL 183 Q+L + + HS+ +VHR+LKP+N+L+ S + +KLADFGLA + A T Sbjct: 135 QQILESIAYCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTP 194 Query: 184 WYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDW 243 Y +PEVL + Y+ PVD+W+ G I + P F D DQ + G D+ Sbjct: 195 GYLSPEVLKKDPYSKPVDIWACGVILYILLVGYPPFW---DEDQHRLYAQIKA--GAYDY 249 Query: 244 PR---DVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 P D P K L+ LT NP KRI+A AL P+ Sbjct: 250 PSPEWDTVTPE---------------------AKSLIDSMLTVNPKKRITADQALKVPWI 288 Query: 301 QDLER 305 + ER Sbjct: 289 CNRER 293 >5J5T-A nrPDB Length = 370 Score = 92.4 bits (228), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 64/213 (30%), Positives = 110/213 (51%), Gaps = 16/213 (7%) Query: 9 ADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHL 68 + + +E + IG G YG V+KAR++ N G A+K ++++ GE+ + +++ ++ + Sbjct: 2 SQEDFELIQRIGSGTYGDVYKARNV-NTGELAAIKVIKLEPGED---FAVVQQEIIM--M 55 Query: 69 ETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQ 128 + +HPN+V F R KL + E + V P + I + + Sbjct: 56 KDCKHPNIVAYFGSYL-----RRDKLWICMEFCGGGSLQDIYHVTGP-LSELQIAYVSRE 109 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGL-ARIYSFQMALTSVVVTLWYRA 187 L+GL +LHS +HRD+K NIL+T +G +KLADFG+ A+I + + + T ++ A Sbjct: 110 TLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKAFIGTPYWMA 169 Query: 188 PEVLL---QSSYATPVDLWSVGCIFAEMFRRKP 217 PEV + Y DLW+VG E+ +P Sbjct: 170 PEVAAVERKGGYNQLCDLWAVGITAIELAELQP 202 >4L42-A nrPDB Length = 346 Score = 92.0 bits (227), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 80/304 (26%), Positives = 136/304 (44%), Gaps = 52/304 (17%) Query: 13 YECVAEIGEGAYGKVFKARDL--KNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRH--- 67 +E + +G+G YGKVF+ R + N G+ A+K ++ + M + ++ A + Sbjct: 20 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLK-----KAMIVRNAKDTAHTKAERN 74 Query: 68 -LETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDM 125 LE +HP +V L KL L+ E++ +L L++ E +T Sbjct: 75 ILEEVKHPFIVDLIYAFQTG-----GKLYLILEYLSGGELFMQLER--EGIFMEDTACFY 127 Query: 126 MFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVV-TLW 184 + ++ L LH +++RDLKP+NI++ G +KL DFGL + +T T+ Sbjct: 128 LAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIE 187 Query: 185 YRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWP 244 Y APE+L++S + VD WS+G + +M P F G + + KIL Sbjct: 188 YMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKIL------------ 235 Query: 245 RDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSA-----LSHPY 299 K + ++T + +DLL K L N A R+ A +HP+ Sbjct: 236 ------------KCKLNLPPYLT---QEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPF 280 Query: 300 FQDL 303 F+ + Sbjct: 281 FRHI 284 >5D9K-A nrPDB Length = 330 Score = 92.0 bits (227), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 86/305 (28%), Positives = 141/305 (46%), Gaps = 22/305 (7%) Query: 3 KDGLCRAD-QQYECVAEIGEGAYGKVFKARDLK--NGGRFVALKRVRVQTGEEGMPLSTI 59 K+G +AD Q+E + +G+G++GKVF + + + + A+K ++ T + + T Sbjct: 21 KEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTK 80 Query: 60 REVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPGVP 118 E +L + HP +V+L E KL L+ + + DL T L K E Sbjct: 81 MERDILVEVN---HPFIVKLHYAFQT-----EGKLYLILDFLRGGDLFTRLSK--EVMFT 130 Query: 119 TETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLAR-IYSFQMALT 177 E +K + +L LD LHS +++RDLKP+NIL+ G IKL DFGL++ + Sbjct: 131 EEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAY 190 Query: 178 SVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDV-IG 236 S T+ Y APEV+ + + D WS G + EM F+G + + IL +G Sbjct: 191 SFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLG 250 Query: 237 LPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALS 296 +P + P +L R F A + ++E+ + + +N Y Sbjct: 251 MP-QFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWN-----KLYRREI 304 Query: 297 HPYFQ 301 HP F+ Sbjct: 305 HPPFK 309 >5XZW-A nrPDB Length = 471 Score = 92.0 bits (227), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 84/302 (27%), Positives = 137/302 (45%), Gaps = 55/302 (18%) Query: 19 IGEGAYGKVFKARDLKNGGRFVA--LKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNV 76 +G+GA+ V KA + G F + + +V +G+ RE+ VL+ L HP + Sbjct: 204 VGQGAFATVKKAIERTTGKTFAVKIISKRKVIGNMDGVT----RELEVLQKLN---HPRI 256 Query: 77 VRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQLLRGLDF 135 VRL D E+ +V E V DL ++ V + +++ Q+L + + Sbjct: 257 VRLKGF----YEDTES-YYMVMEFVSGGDLMDFV--AAHGAVGEDAGREISRQILTAIKY 309 Query: 136 LHSHRVVHRDLKPQNILVTSSGQ--IKLADFGLARIYSFQMALTSVVVTLWYRAPEVLL- 192 +HS + HRDLKP NIL+ +K+ DFGLA++ + + TL Y APEV+ Sbjct: 310 IHSMGISHRDLKPDNILIEQDDPVLVKITDFGLAKVQGNGSFMKTFCGTLAYVAPEVIRG 369 Query: 193 ------------QSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGE 240 ++ Y++ VD+WS+GC+ + F GS+ DQL K Sbjct: 370 KDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQ-DQLYK---------- 418 Query: 241 EDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 + R ++H P++ F I E +D + L +P R +A AL+HP+ Sbjct: 419 -------QIGRGSYHEG---PLKDF--RISEEARDFIDSLLQVDPNNRSTAAKALNHPWI 466 Query: 301 QD 302 D Sbjct: 467 VD 468 >2UV2-A nrPDB Length = 325 Score = 92.0 bits (227), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 84/293 (28%), Positives = 129/293 (44%), Gaps = 41/293 (13%) Query: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 +E + E+G+GA+GKV+KA++ K A K + ++ EE + E+ +L + + Sbjct: 39 WEIIGELGDGAFGKVYKAQN-KETSVLAAAKVIDTKSEEELE--DYMVEIDILA---SCD 92 Query: 73 HPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRG 132 HPN+V+L D E L ++ E + E + I+ + Q L Sbjct: 93 HPNIVKLLDAFYY-----ENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDA 147 Query: 133 LDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGL-ARIYSFQMALTSVVVTLWYRAPEVL 191 L++LH ++++HRDLK NIL T G IKLADFG+ A+ S + T ++ APEV+ Sbjct: 148 LNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVV 207 Query: 192 LQSS-----YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRD 246 + + Y D+WS+G EM +P P E P Sbjct: 208 MCETSKDRPYDYKADVWSLGITLIEMAEIEP--------------------PHHELNPMR 247 Query: 247 VALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPY 299 V L +KS P + KD L KCL N R + L HP+ Sbjct: 248 VLLKI----AKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPF 296 >2Q0N-A nrPDB Length = 301 Score = 91.7 bits (226), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 78/284 (27%), Positives = 136/284 (47%), Gaps = 38/284 (13%) Query: 18 EIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVV 77 +IGEG+ G V A +++ G+ VA+K++ ++ + L EV ++R ++H NVV Sbjct: 36 KIGEGSTGIVCIA-TVRSSGKLVAVKKMDLRKQQRRELL--FNEVVIMR---DYQHENVV 89 Query: 78 RLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLH 137 +++ V +L +V E ++ T D V + E I + +L+ L LH Sbjct: 90 EMYNSYLVG-----DELWVVMEFLEGGALT--DIVTHTRMNEEQIAAVCLAVLQALSVLH 142 Query: 138 SHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMA-LTSVVVTLWYRAPEVLLQSSY 196 + V+HRD+K +IL+T G++KL+DFG S ++ S+V T ++ APE++ + Y Sbjct: 143 AQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPY 202 Query: 197 ATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHS 256 VD+WS+G + EM +P + + + I RD PR Sbjct: 203 GPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMI-------------RDNLPPRLKNLH 249 Query: 257 KSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 K + ++ F L + L +PA+R +A L HP+ Sbjct: 250 KVSPSLKGF-----------LDRLLVRDPAQRATAAELLKHPFL 282 >4RLP-A nrPDB Length = 288 Score = 91.7 bits (226), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 81/304 (26%), Positives = 138/304 (45%), Gaps = 52/304 (17%) Query: 13 YECVAEIGEGAYGKVFKARDL--KNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRH--- 67 +E + +G+G YGKVF+ R + N G+ A+K ++ + M + ++ A + Sbjct: 7 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLK-----KAMIVRNAKDTAHTKAERN 61 Query: 68 -LETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDM 125 LE +HP +V D+ +T KL L+ E++ +L L++ E +T Sbjct: 62 ILEEVKHPFIV---DLIYAFQTG--GKLYLILEYLSGGELFMQLER--EGIFMEDTACFY 114 Query: 126 MFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVV-TLW 184 + ++ L LH +++RDLKP+NI++ G +KL DFGL + +T T+ Sbjct: 115 LAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIE 174 Query: 185 YRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWP 244 Y APE+L++S + VD WS+G + +M P F G + + KIL Sbjct: 175 YMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKC---------- 224 Query: 245 RDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSA-----LSHPY 299 + LP + + +DLL K L N A R+ A +HP+ Sbjct: 225 -KLNLPPY----------------LTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPF 267 Query: 300 FQDL 303 F+ + Sbjct: 268 FRHI 271 >6DBN-A nrPDB Length = 316 Score = 91.7 bits (226), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 71/231 (30%), Positives = 113/231 (48%), Gaps = 25/231 (10%) Query: 16 VAEIGEGAYGKVFKAR---DLKNGGRFVALKRVRVQTGEEGMPLSTIR-EVAVLRHLETF 71 + ++GEG +GKV R + N G VA+K ++ ++G G ++ ++ E+ +LR+L Sbjct: 40 IRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESG--GNHIADLKKEIEILRNLY-- 95 Query: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPGVPTETIKDMMFQLL 130 H N+V+ +CT D + L+ E + L YL K + +K Q+ Sbjct: 96 -HENIVKYKGICT---EDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLK-YAVQIC 150 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSV-----VVTLWY 185 +G+D+L S + VHRDL +N+LV S Q+K+ DFGL + +V WY Sbjct: 151 KGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWY 210 Query: 186 RAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIG 236 APE L+QS + D+WS G E+ L SD + L +IG Sbjct: 211 -APECLMQSKFYIASDVWSFGVTLHEL-----LTYCDSDSSPMALFLKMIG 255 >4FIE-A nrPDB Length = 423 Score = 91.7 bits (226), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 80/286 (27%), Positives = 135/286 (47%), Gaps = 42/286 (14%) Query: 18 EIGEGAYGKVFKARDLKNGGRFVALKRV--RVQTGEEGMPLSTIREVAVLRHLETFEHPN 75 +IGEG+ G V A +++ G+ VA+K++ R Q E + EV ++R ++H N Sbjct: 158 KIGEGSTGIVCIA-TVRSSGKLVAVKKMDLRKQQRRELL----FNEVVIMR---DYQHEN 209 Query: 76 VVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDF 135 VV +++ V +L +V E ++ T D V + E I + +L+ L Sbjct: 210 VVEMYNSYLVG-----DELWVVMEFLEGGALT--DIVTHTRMNEEQIAAVCLAVLQALSV 262 Query: 136 LHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMA-LTSVVVTLWYRAPEVLLQS 194 LH+ V+HRD+K +IL+T G++KL+DFG S ++ S+V T ++ APE++ + Sbjct: 263 LHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRL 322 Query: 195 SYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAF 254 Y VD+WS+G + EM +P + + + I D LP Sbjct: 323 PYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRD--NLP---------------- 364 Query: 255 HSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 P K + + K L + L +PA+R +A L HP+ Sbjct: 365 ------PRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFL 404 >4JDH-A nrPDB Length = 346 Score = 91.7 bits (226), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 78/284 (27%), Positives = 136/284 (47%), Gaps = 38/284 (13%) Query: 18 EIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVV 77 +IGEG+ G V A +++ G+ VA+K++ ++ + L EV ++R ++H NVV Sbjct: 81 KIGEGSTGIVCIA-TVRSSGKLVAVKKMDLRKQQRRELL--FNEVVIMR---DYQHENVV 134 Query: 78 RLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLH 137 +++ V +L +V E ++ T D V + E I + +L+ L LH Sbjct: 135 EMYNSYLVG-----DELWVVMEFLEGGALT--DIVTHTRMNEEQIAAVCLAVLQALSVLH 187 Query: 138 SHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMA-LTSVVVTLWYRAPEVLLQSSY 196 + V+HRD+K +IL+T G++KL+DFG S ++ S+V T ++ APE++ + Y Sbjct: 188 AQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPY 247 Query: 197 ATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHS 256 VD+WS+G + EM +P + + + I RD PR Sbjct: 248 GPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMI-------------RDNLPPRLKNLH 294 Query: 257 KSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 K + ++ F L + L +PA+R +A L HP+ Sbjct: 295 KVSPSLKGF-----------LDRLLVRDPAQRATAAELLKHPFL 327 >5D7A-A nrPDB Length = 308 Score = 90.9 bits (224), Expect = 8e-19, Method: Compositional matrix adjust. Identities = 84/298 (28%), Positives = 142/298 (47%), Gaps = 39/298 (13%) Query: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 +E V +G G YG+V+K R +K G + A+K + V TG+E + +E+ +L+ Sbjct: 19 FELVELVGNGTYGQVYKGRHVKTG-QLAAIKVMDV-TGDEEEEIK--QEINMLKKYS--H 72 Query: 73 HPNVVRLFDV-CTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPG-VPTETIKDMMFQLL 130 H N+ + + + +L LV E T L K + + E I + ++L Sbjct: 73 HRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREIL 132 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGL-ARIYSFQMALTSVVVTLWYRAPE 189 RGL LH H+V+HRD+K QN+L+T + ++KL DFG+ A++ + + T ++ APE Sbjct: 133 RGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 192 Query: 190 VLL-----QSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWP 244 V+ ++Y DLWS+G EM P D+ + + + P Sbjct: 193 VIACDENPDATYDFKSDLWSLGITAIEMAEGAPPL---CDMHPMRALFLI---------P 240 Query: 245 RDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQD 302 R+ A PR KS + +KF + I+ CL N ++R + + HP+ +D Sbjct: 241 RNPA-PR----LKSKKWSKKFQSFIES--------CLVKNHSQRPATEQLMKHPFIRD 285 >2Y7J-A nrPDB Length = 365 Score = 90.9 bits (224), Expect = 8e-19, Method: Compositional matrix adjust. Identities = 85/305 (27%), Positives = 134/305 (43%), Gaps = 48/305 (15%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRF------VALKRVRVQTGEEGMPLSTIREVAV 64 Q+Y+ IG G V + G F V +R+ + EE + +T RE + Sbjct: 94 QKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEE-VREATRRETHI 152 Query: 65 LRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYL-DKVPEPGVPTETI 122 LR + HP+++ L D S + + LVF+ + + +L YL +KV + + Sbjct: 153 LRQVAG--HPHIITLIDSYESS-----SFMFLVFDLMRKGELFDYLTEKV---ALSEKET 202 Query: 123 KDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVT 182 + +M LL + FLH++ +VHRDLKP+NIL+ + QI+L+DFG + L + T Sbjct: 203 RSIMRSLLEAVSFLHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEPGEKLRELCGT 262 Query: 183 LWYRAPEVLLQS------SYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIG 236 Y APE+L S Y VDLW+ G I + P F + L I++ Sbjct: 263 PGYLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQY 322 Query: 237 LPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALS 296 +W D KDL+ + L +P R++A AL Sbjct: 323 QFSSPEW-----------------------DDRSSTVKDLISRLLQVDPEARLTAEQALQ 359 Query: 297 HPYFQ 301 HP+F+ Sbjct: 360 HPFFE 364 >1S9I-A nrPDB Length = 354 Score = 90.5 bits (223), Expect = 9e-19, Method: Compositional matrix adjust. Identities = 86/321 (26%), Positives = 145/321 (45%), Gaps = 42/321 (13%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLE 69 D +E ++E+G G G V K + + G +A K + ++ + + IRE+ VL Sbjct: 15 DDDFERISELGAGNGGVVTKVQH-RPSGLIMARKLIHLEI-KPAIRNQIIRELQVLHECN 72 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPG--VPTETIKDMMF 127 + P +V + + ++++ EH+D LD+V + +P E + + Sbjct: 73 S---PYIVGFYGAFY-----SDGEISICMEHMD---GGSLDQVLKEAKRIPEEILGKVSI 121 Query: 128 QLLRGLDFL-HSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYR 186 +LRGL +L H+++HRD+KP NILV S G+IKL DFG++ MA S V T Y Sbjct: 122 AVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA-NSFVGTRSYM 180 Query: 187 APEVLLQSSYATPVDLWSVGCIFAEM-FRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPR 245 APE L + Y+ D+WS+G E+ R P+ D +L I + GEE P Sbjct: 181 APERLQGTHYSVQSDIWSMGLSLVELAVGRYPI--PPPDAKELEAIFGRPVVDGEEGEPH 238 Query: 246 DVALPRQ------AFHSKSAQPIEKFVTDIDELG----------------KDLLLKCLTF 283 ++ + + H ++P +D + ++ + KCL Sbjct: 239 SISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIK 298 Query: 284 NPAKRISAYSALSHPYFQDLE 304 NPA+R +H + + E Sbjct: 299 NPAERADLKMLTNHTFIKRSE 319 >4YZB-A nrPDB Length = 491 Score = 90.5 bits (223), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 60/200 (30%), Positives = 98/200 (49%), Gaps = 30/200 (15%) Query: 128 QLLRGLDFLHSHRVVHRDLKPQNILVTSS---GQIKLADFGLARIYSFQMALTSVVVTLW 184 Q+L G+ ++H +++VHRDLKP+N+L+ + I++ DFGL+ + + + T + Sbjct: 138 QVLSGITYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAY 197 Query: 185 YRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWP 244 Y APEV L +Y D+WS G I + P F G+++ D L K+ E Sbjct: 198 YIAPEV-LHGTYDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKV---------EKGK 247 Query: 245 RDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLE 304 LP+ K ++P KDL+ K L + P RISA AL H + + + Sbjct: 248 FTFDLPQ---WKKVSEP-----------AKDLIRKMLAYVPTMRISARDALEHEWLKTTD 293 Query: 305 RCKENLDSHLPPSQNTSELN 324 +++D PS ++ LN Sbjct: 294 AATDSID---VPSLESTILN 310 >4AN9-A nrPDB Length = 301 Score = 90.1 bits (222), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 80/299 (26%), Positives = 136/299 (45%), Gaps = 50/299 (16%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLE 69 D +E ++E+G G G VFK K G +A K + ++ + + IRE+ VL Sbjct: 8 DDDFEKISELGAGNGGVVFKVSH-KPSGLVMARKLIHLEI-KPAIRNQIIRELQVLHECN 65 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPG--VPTETIKDMMF 127 + P +V + + ++++ EH+D LD+V + +P + + + Sbjct: 66 S---PYIVGFYGAFY-----SDGEISICMEHMD---GGSLDQVLKKAGRIPEQILGKVSI 114 Query: 128 QLLRGLDFL-HSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYR 186 +++GL +L H+++HRD+KP NILV S G+IKL DFG++ +MA V T Y Sbjct: 115 AVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDEMA-NEFVGTRSYM 173 Query: 187 APEVLLQSSYATPVDLWSVGCIFAEM----FRRKPLFRGSSDVDQLGKILDVIGLPGEED 242 +PE L + Y+ D+WS+G EM + R P+ I +++ E Sbjct: 174 SPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPRPPM-----------AIFELLDYIVNEP 222 Query: 243 WPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQ 301 P+ LP F + +D + KCL NPA+R + H + + Sbjct: 223 PPK---LPSAVFSLEF---------------QDFVNKCLIKNPAERADLKQLMVHAFIK 263 >1PHK-A nrPDB Length = 298 Score = 90.1 bits (222), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 86/281 (30%), Positives = 123/281 (43%), Gaps = 48/281 (17%) Query: 29 KARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRT 88 K D+ GG F A + VQ E +T++EV +LR + HPN+++L D Sbjct: 48 KIIDVTGGGSFSAEE---VQELRE----ATLKEVDILRKVSG--HPNIIQLKDT-----Y 93 Query: 89 DRETKLTLVFEHVDQ-DLTTYL-DKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDL 146 + T LVF+ + + +L YL +KV + + + +M LL + LH +VHRDL Sbjct: 94 ETNTFFFLVFDLMKKGELFDYLTEKVT---LSEKETRKIMRALLEVICALHKLNIVHRDL 150 Query: 147 KPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQS------SYATPV 200 KP+NIL+ IKL DFG + L V T Y APE++ S Y V Sbjct: 151 KPENILLDDDMNIKLTDFGFSCQLDPGEKLREVCGTPSYLAPEIIECSMNDNHPGYGKEV 210 Query: 201 DLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQ 260 D+WS G I + P F W R L + S + Q Sbjct: 211 DMWSTGVIMYTLLAGSPPF-----------------------WHRKQMLMLRMIMSGNYQ 247 Query: 261 PIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQ 301 D + KDL+ + L P KR +A AL+HP+FQ Sbjct: 248 FGSPEWDDYSDTVKDLVSRFLVVQPQKRYTAEEALAHPFFQ 288 >2A1A-B nrPDB Length = 284 Score = 89.7 bits (221), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 62/207 (29%), Positives = 102/207 (49%), Gaps = 22/207 (10%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVR 78 IG G +G+VFKA+ +G +V +KRV+ + REV L L+ H N+V Sbjct: 19 IGSGGFGQVFKAKHRIDGKTYV-IKRVKYNNEK------AEREVKALAKLD---HVNIVH 68 Query: 79 L--------FDVCTVSRTDRETKLTLVF---EHVDQD-LTTYLDKVPEPGVPTETIKDMM 126 +D T S+ +K +F E D+ L +++K + ++ Sbjct: 69 YNGCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELF 128 Query: 127 FQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYR 186 Q+ +G+D++HS ++++RDLKP NI + + Q+K+ DFGL T TL Y Sbjct: 129 EQITKGVDYIHSKKLINRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYM 188 Query: 187 APEVLLQSSYATPVDLWSVGCIFAEMF 213 +PE + Y VDL+++G I AE+ Sbjct: 189 SPEQISSQDYGKEVDLYALGLILAELL 215 >6CQF-A nrPDB Length = 297 Score = 89.7 bits (221), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 87/295 (29%), Positives = 141/295 (47%), Gaps = 48/295 (16%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETF 71 Y+ + +G G YG+VFKARD K G VALK V+++ ++ +ST+++ ++ L+T Sbjct: 17 HYDLLQRLGGGTYGEVFKARD-KVSGDLVALKMVKMEPDDD---VSTLQKEILI--LKTC 70 Query: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVD----QDLTTYLDKVPEPGVPTETIKDMMF 127 H N+V + KL + E QD+ + E I + Sbjct: 71 RHANIVAYHGSYLWLQ-----KLWICMEFCGAGSLQDIYQVTGSLSE-----LQISYVCR 120 Query: 128 QLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGL-ARIYSFQMALTSVVVTLWYR 186 ++L+GL +LHS + +HRD+K NIL+ +G+++LADFG+ A+I + + + T ++ Sbjct: 121 EVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLAFIGTPYWM 180 Query: 187 APE---VLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILDVIGLPGEED 242 APE V L+ Y D+WS+G E+ + PLF DV L ++L ++ G + Sbjct: 181 APEVAAVALKGGYNELCDIWSLGITAIELAELQPPLF----DVHPL-RVLFLMTKSGYQP 235 Query: 243 WPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSH 297 PR K + F+ LT +P KR SA LSH Sbjct: 236 -------PRLKEKGKWSAAFHNFIK-----------VTLTKSPKKRPSATKMLSH 272 >5VO2-A nrPDB Length = 300 Score = 89.7 bits (221), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 69/244 (28%), Positives = 114/244 (46%), Gaps = 29/244 (11%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVR 78 +G GA G VF R G VA+K+VR ++E + +HL +HPN++ Sbjct: 20 VGSGAQGAVFLGR---FHGEEVAVKKVR-----------DLKETDI-KHLRKLKHPNIIT 64 Query: 79 LFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHS 138 VCT + ++ E Q + + P P+ + D + G+++LH Sbjct: 65 FKGVCT-----QAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLV-DWSMGIAGGMNYLHL 118 Query: 139 HRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYAT 198 H+++HRDLK N+L+T +K++DFG ++ S + S T+ + APEV+ + Sbjct: 119 HKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSE 178 Query: 199 PVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDV----IGLPGEEDWPRDVA-LPRQA 253 VD+WS G + E+ + ++ DVD I V + LP P L RQ Sbjct: 179 KVDIWSFGVVLWELLTGEIPYK---DVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQC 235 Query: 254 FHSK 257 ++SK Sbjct: 236 WNSK 239 >4E93-A nrPDB Length = 377 Score = 89.7 bits (221), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 63/202 (31%), Positives = 103/202 (50%), Gaps = 19/202 (9%) Query: 18 EIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVV 77 +IG G +G+VF R L+ VA+K R +T + ++E +L+ + HPN+V Sbjct: 121 QIGRGNFGEVFSGR-LRADNTLVAVKSCR-ETLPPDLKAKFLQEARILKQ---YSHPNIV 175 Query: 78 RLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFL 136 RL VCT ++ + +V E V D T+L + + +T+ M+ G+++L Sbjct: 176 RLIGVCT-----QKQPIYIVMELVQGGDFLTFL-RTEGARLRVKTLLQMVGDAAAGMEYL 229 Query: 137 HSHRVVHRDLKPQNILVTSSGQIKLADFGLAR-----IYSFQMALTSVVVTLWYRAPEVL 191 S +HRDL +N LVT +K++DFG++R +Y+ L V V + APE L Sbjct: 230 ESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVK--WTAPEAL 287 Query: 192 LQSSYATPVDLWSVGCIFAEMF 213 Y++ D+WS G + E F Sbjct: 288 NYGRYSSESDVWSFGILLWETF 309 >3EQC-A nrPDB Length = 360 Score = 89.4 bits (220), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 64/206 (31%), Positives = 106/206 (51%), Gaps = 17/206 (8%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLE 69 D +E ++E+G G G VFK K G +A K + ++ + + IRE+ VL Sbjct: 32 DDDFEKISELGAGNGGVVFKVSH-KPSGLVMARKLIHLEI-KPAIRNQIIRELQVLHECN 89 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPG--VPTETIKDMMF 127 + P +V + + ++++ EH+D LD+V + +P + + + Sbjct: 90 S---PYIVGFYGAFY-----SDGEISICMEHMD---GGSLDQVLKKAGRIPEQILGKVSI 138 Query: 128 QLLRGLDFL-HSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYR 186 +++GL +L H+++HRD+KP NILV S G+IKL DFG++ MA S V T Y Sbjct: 139 AVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA-NSFVGTRSYM 197 Query: 187 APEVLLQSSYATPVDLWSVGCIFAEM 212 +PE L + Y+ D+WS+G EM Sbjct: 198 SPERLQGTHYSVQSDIWSMGLSLVEM 223 >5KKR-C nrPDB Length = 395 Score = 89.4 bits (220), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 64/206 (31%), Positives = 106/206 (51%), Gaps = 17/206 (8%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLE 69 D +E ++E+G G G VFK K G +A K + ++ + + IRE+ VL Sbjct: 67 DDDFEKISELGAGNGGVVFKVSH-KPSGLVMARKLIHLEI-KPAIRNQIIRELQVLHECN 124 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPG--VPTETIKDMMF 127 + P +V + + ++++ EH+D LD+V + +P + + + Sbjct: 125 S---PYIVGFYGAFY-----SDGEISICMEHMD---GGSLDQVLKKAGRIPEQILGKVSI 173 Query: 128 QLLRGLDFL-HSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYR 186 +++GL +L H+++HRD+KP NILV S G+IKL DFG++ MA S V T Y Sbjct: 174 AVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA-NSFVGTRSYM 232 Query: 187 APEVLLQSSYATPVDLWSVGCIFAEM 212 +PE L + Y+ D+WS+G EM Sbjct: 233 SPERLQGTHYSVQSDIWSMGLSLVEM 258 >2WTK-C nrPDB Length = 305 Score = 89.4 bits (220), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 84/310 (27%), Positives = 134/310 (43%), Gaps = 40/310 (12%) Query: 19 IGEGAYGKVFKARDLKN-GGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVV 77 +GEG+YGKV + D + R V + + + + +E+ +LR L H NV+ Sbjct: 13 LGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLR---HKNVI 69 Query: 78 RLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLH 137 +L DV + + K+ +V E+ + LD VPE P QL+ GL++LH Sbjct: 70 QLVDVLY---NEEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLIDGLEYLH 126 Query: 138 SHRVVHRDLKPQNILVTSSGQIKLADFGLAR-IYSFQMALTSVVV--TLWYRAPEVL--L 192 S +VH+D+KP N+L+T+ G +K++ G+A ++ F T + ++ PE+ L Sbjct: 127 SQGIVHKDIKPGNLLLTTGGTLKISALGVAEALHPFAADDTCRTSQGSPAFQPPEIANGL 186 Query: 193 QSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQ 252 + VD+WS G + F G D + K+ + IG G P D P Sbjct: 187 DTFSGFKVDIWSAGVTLYNITTGLYPFEG----DNIYKLFENIG-KGSYAIPGDCGPPLS 241 Query: 253 AFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDS 312 DLL L + PAKR S H +F+ E Sbjct: 242 ----------------------DLLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAE-APV 278 Query: 313 HLPPSQNTSE 322 +PPS +T + Sbjct: 279 PIPPSPDTKD 288 >4YNZ-A nrPDB Length = 342 Score = 89.4 bits (220), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 58/172 (33%), Positives = 89/172 (51%), Gaps = 12/172 (6%) Query: 40 VALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFE 99 VA+K V + E + + RE+A+L+ EHP+V++L DV + + L LV E Sbjct: 38 VAIKIVNREKLSESVLMKVEREIAILK---LIEHPHVLKLHDV-----YENKKYLYLVLE 89 Query: 100 HVDQ-DLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQ 158 HV +L YL V + + + + Q++ LDF HSH + HRDLKP+N+L+ Sbjct: 90 HVSGGELFDYL--VKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKPENLLLDERNN 147 Query: 159 IKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSY-ATPVDLWSVGCIF 209 I++ADFG+A + L + + Y PEV+ Y D+WS G I Sbjct: 148 IRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVIL 199 >4C59-A nrPDB Length = 340 Score = 89.0 bits (219), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 66/227 (29%), Positives = 117/227 (51%), Gaps = 28/227 (12%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVR 78 + EG + V++A+D+ GR ALKR+ + EE + I+EV ++ L HPN+V+ Sbjct: 35 LAEGGFAFVYEAQDV-GSGREYALKRLL--SNEEEKNRAIIQEVCFMKKLSG--HPNIVQ 89 Query: 79 LFDVCTVSRTDRET---KLTLVFEHVDQDLTTYLDKVPEPG-VPTETIKDMMFQLLRGLD 134 ++ + + +T + L+ E L +L K+ G + +T+ + +Q R + Sbjct: 90 FCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGPLSCDTVLKIFYQTCRAVQ 149 Query: 135 FLHSHR--VVHRDLKPQNILVTSSGQIKLADFGLARI------YSFQMALTSVV------ 180 +H + ++HRDLK +N+L+++ G IKL DFG A YS+ ++V Sbjct: 150 HMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEEEITR 209 Query: 181 -VTLWYRAPEVL-LQSSY--ATPVDLWSVGCI-FAEMFRRKPLFRGS 222 T YR PE++ L S++ D+W++GCI + FR+ P G+ Sbjct: 210 NTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDGA 256 >5YV8-A nrPDB Length = 298 Score = 89.0 bits (219), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 93/327 (28%), Positives = 148/327 (45%), Gaps = 70/327 (21%) Query: 5 GLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALK-----RVRVQTG--------- 50 G C QY EIG+G+YG V A + +N + A+K ++ Q G Sbjct: 7 GDCVQLNQYTLKDEIGKGSYGVVKLAYN-ENDNTYYAMKVLSKKKLIRQAGFPRRPPPRG 65 Query: 51 ---------EEGMPLSTI-REVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEH 100 + P+ + +E+A+L+ L+ HPNVV+L +V D L +VFE Sbjct: 66 TRPAPGGCIQPRGPIEQVYQEIAILKKLD---HPNVVKLVEVLDDPNEDH---LYMVFEL 119 Query: 101 VDQDLTTYLDKVPEPGVPTETIKDMMFQ-LLRGLDFLHSHRVVHRDLKPQNILVTSSGQI 159 V+Q +VP +E FQ L++G+++LH +++HRD+KP N+LV G I Sbjct: 120 VNQGPVM---EVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHI 176 Query: 160 KLADFGLARIYSFQMALTSVVV-TLWYRAPEVLLQSS---YATPVDLWSVGC-IFAEMFR 214 K+ADFG++ + AL S V T + APE L ++ +D+W++G ++ +F Sbjct: 177 KIADFGVSNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFG 236 Query: 215 RKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKF--VTDIDEL 272 + P +D+ +I+ HSK +F DI E Sbjct: 237 QCPF------MDE--RIM--------------------CLHSKIKSQALEFPDQPDIAED 268 Query: 273 GKDLLLKCLTFNPAKRISAYSALSHPY 299 KDL+ + L NP RI HP+ Sbjct: 269 LKDLITRMLDKNPESRIVVPEIKLHPW 295 >4FR4-A nrPDB Length = 384 Score = 89.0 bits (219), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 76/299 (25%), Positives = 135/299 (45%), Gaps = 43/299 (14%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTI-REVAVLRHLET 70 +E + IG+G++GKV + + + A+K + Q E + + +E+ +++ LE Sbjct: 16 HFEILRAIGKGSFGKVCIVQK-NDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQGLE- 73 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130 HP +V L+ S D E +V + DL +L + ET+K + +L+ Sbjct: 74 --HPFLVNLW----YSFQDEEDMFMVVDLLLGGDLRYHLQQ--NVHFKEETVKLFICELV 125 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEV 190 LD+L + R++HRD+KP NIL+ G + + DF +A + + +T++ T Y APE+ Sbjct: 126 MALDYLQNQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQITTMAGTKPYMAPEM 185 Query: 191 LLQ---SSYATPVDLWSVGCIFAEMFR-RKPL-FRGSSDVDQLGKILDVIGLPGEEDWPR 245 + Y+ VD WS+G E+ R R+P R S+ ++ + + W + Sbjct: 186 FSSRKGAGYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHTFETTVVTYPSAWSQ 245 Query: 246 DVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSH-PYFQDL 303 ++ LL K L NP +R S S + + PY D+ Sbjct: 246 EMV--------------------------SLLKKLLEPNPDQRFSQLSDVQNFPYMNDI 278 >3VN9-A nrPDB Length = 340 Score = 88.6 bits (218), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 80/296 (27%), Positives = 135/296 (45%), Gaps = 44/296 (14%) Query: 14 ECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQ-TGEEGMPLSTIREVAVLRHLETFE 72 E + E+G GAYG V K R + +G + +A+KR+R +E L +++ + T + Sbjct: 54 EPIMELGRGAYGVVEKMRHVPSG-QIMAVKRIRATVNSQEQKRLLMDLDIS----MRTVD 108 Query: 73 HPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPG--VPTETIKDMMFQLL 130 P V + RE + + E +D L + +V + G +P + + + ++ Sbjct: 109 CPFTVTFYGALF-----REGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIV 163 Query: 131 RGLDFLHSH-RVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPE 189 + L+ LHS V+HRD+KP N+L+ + GQ+K+ DFG++ +A T Y APE Sbjct: 164 KALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPE 223 Query: 190 ----VLLQSSYATPVDLWSVGCIFAEM-FRRKPLFRGSSDVDQLGKILDVIGLPGEEDWP 244 L Q Y+ D+WS+G E+ R P + QL +++ EE P Sbjct: 224 RINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVV-------EEPSP 276 Query: 245 RDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 + LP F + +FV D +CL N +R + + HP+F Sbjct: 277 Q---LPADKFSA-------EFV--------DFTSQCLKKNSKERPTYPELMQHPFF 314 >4RED-A nrPDB Length = 351 Score = 88.6 bits (218), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 64/197 (32%), Positives = 102/197 (51%), Gaps = 12/197 (6%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVR 78 +G G +GKV K + G VA+K + Q + IR +++L+ F HP++++ Sbjct: 22 LGVGTFGKV-KVGKHELTGHAVAVKILNRQKIRSLDVVGKIRRE--IQNLKLFRHPHIIK 78 Query: 79 LFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQ-LLRGLDFLH 137 L+ V + + + +V E+V D + + G E +FQ +L G+D+ H Sbjct: 79 LYQVISTP-----SDIFMVMEYVSG--GELFDYICKNGRLDEKESRRLFQQILSGVDYCH 131 Query: 138 SHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYA 197 H VVHRDLKP+N+L+ + K+ADFGL+ + S L + + Y APEV+ YA Sbjct: 132 RHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYA 191 Query: 198 TP-VDLWSVGCIFAEMF 213 P VD+WS G I + Sbjct: 192 GPEVDIWSSGVILYALL 208 >1LUF-A nrPDB Length = 343 Score = 88.6 bits (218), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 68/230 (29%), Positives = 113/230 (49%), Gaps = 39/230 (16%) Query: 14 ECVAEIGEGAYGKVFKARDLK----NGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLE 69 E V +IGEGA+G+VF+AR VA+K ++ + + M RE A++ Sbjct: 50 EYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASAD-MQADFQREAALMAE-- 106 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYL------------------- 109 F++PN+V+L VC V + + L+FE++ DL +L Sbjct: 107 -FDNPNIVKLLGVCAVGK-----PMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTR 160 Query: 110 DKVPEPGVPTETIKDMMF---QLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGL 166 +V PG P + + + Q+ G+ +L + VHRDL +N LV + +K+ADFGL Sbjct: 161 ARVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGL 220 Query: 167 AR-IYS--FQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMF 213 +R IYS + A + + + + PE + + Y T D+W+ G + E+F Sbjct: 221 SRNIYSADYYKADGNDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIF 270 >4REW-A nrPDB Length = 540 Score = 88.6 bits (218), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 64/197 (32%), Positives = 102/197 (51%), Gaps = 12/197 (6%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVR 78 +G G +GKV K + G VA+K + Q + IR +++L+ F HP++++ Sbjct: 14 LGVGTFGKV-KVGKHELTGHKVAVKILNRQKIRSLDVVGKIRRE--IQNLKLFRHPHIIK 70 Query: 79 LFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQ-LLRGLDFLH 137 L+ V + + + +V E+V D + + G E +FQ +L G+D+ H Sbjct: 71 LYQVISTP-----SDIFMVMEYVSG--GELFDYICKNGRLDEKESRRLFQQILSGVDYCH 123 Query: 138 SHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYA 197 H VVHRDLKP+N+L+ + K+ADFGL+ + S L + + Y APEV+ YA Sbjct: 124 RHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYA 183 Query: 198 TP-VDLWSVGCIFAEMF 213 P VD+WS G I + Sbjct: 184 GPEVDIWSSGVILYALL 200 >3UTO-A nrPDB Length = 573 Score = 88.6 bits (218), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 80/316 (25%), Positives = 135/316 (42%), Gaps = 48/316 (15%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETF 71 Y+ E+G GA+G V + + G F A + ++ I+ ++VLRH Sbjct: 158 HYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKETVRKEIQTMSVLRH---- 213 Query: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-----QDLTTYLDKVPEPGVPTETIKDMM 126 P +V L D + + ++ +++E + + + +K+ E + + M Sbjct: 214 --PTLVNLHDAF-----EDDNEMVMIYEFMSGGELFEKVADEHNKMSE-----DEAVEYM 261 Query: 127 FQLLRGLDFLHSHRVVHRDLKPQNILVTS--SGQIKLADFGLARIYSFQMALTSVVVTLW 184 Q+ +GL +H + VH DLKP+NI+ T+ S ++KL DFGL + ++ T Sbjct: 262 RQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTTGTAE 321 Query: 185 YRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWP 244 + APEV D+WSVG + + F G +D + L + DW Sbjct: 322 FAAPEVAEGKPVGYYTDMWSVGVLSYILLSGLSPFGGENDDETLRNVKSC-------DWN 374 Query: 245 RDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLE 304 D + AF + I E GKD + K L +P R++ + AL HP+ Sbjct: 375 MDDS----AF------------SGISEDGKDFIRKLLLADPNTRMTIHQALEHPWL--TP 416 Query: 305 RCKENLDSHLPPSQNT 320 DS +P S+ T Sbjct: 417 GNAPGRDSQIPSSRYT 432 >1KOA-A nrPDB Length = 491 Score = 88.6 bits (218), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 80/316 (25%), Positives = 135/316 (42%), Gaps = 48/316 (15%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETF 71 Y+ E+G GA+G V + + G F A + ++ I+ ++VLRH Sbjct: 52 HYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKETVRKEIQTMSVLRH---- 107 Query: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-----QDLTTYLDKVPEPGVPTETIKDMM 126 P +V L D + + ++ +++E + + + +K+ E + + M Sbjct: 108 --PTLVNLHDAF-----EDDNEMVMIYEFMSGGELFEKVADEHNKMSE-----DEAVEYM 155 Query: 127 FQLLRGLDFLHSHRVVHRDLKPQNILVTS--SGQIKLADFGLARIYSFQMALTSVVVTLW 184 Q+ +GL +H + VH DLKP+NI+ T+ S ++KL DFGL + ++ T Sbjct: 156 RQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTTGTAE 215 Query: 185 YRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWP 244 + APEV D+WSVG + + F G +D + L + DW Sbjct: 216 FAAPEVAEGKPVGYYTDMWSVGVLSYILLSGLSPFGGENDDETLRNVKSC-------DWN 268 Query: 245 RDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLE 304 D + AF + I E GKD + K L +P R++ + AL HP+ Sbjct: 269 MDDS----AF------------SGISEDGKDFIRKLLLADPNTRMTIHQALEHPWL--TP 310 Query: 305 RCKENLDSHLPPSQNT 320 DS +P S+ T Sbjct: 311 GNAPGRDSQIPSSRYT 326 >4CFH-A nrPDB Length = 493 Score = 88.2 bits (217), Expect = 5e-18, Method: Compositional matrix adjust. Identities = 64/197 (32%), Positives = 102/197 (51%), Gaps = 12/197 (6%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVR 78 +G G +GKV K + G VA+K + Q + IR +++L+ F HP++++ Sbjct: 41 LGVGTFGKV-KVGKHELTGHKVAVKILNRQKIRSLDVVGKIRRE--IQNLKLFRHPHIIK 97 Query: 79 LFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQ-LLRGLDFLH 137 L+ V + + + +V E+V D + + G E +FQ +L G+D+ H Sbjct: 98 LYQVISTP-----SDIFMVMEYVSG--GELFDYICKNGRLDEKESRRLFQQILSGVDYCH 150 Query: 138 SHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYA 197 H VVHRDLKP+N+L+ + K+ADFGL+ + S L + + Y APEV+ YA Sbjct: 151 RHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYA 210 Query: 198 TP-VDLWSVGCIFAEMF 213 P VD+WS G I + Sbjct: 211 GPEVDIWSSGVILYALL 227 >5F9E-A nrPDB Length = 353 Score = 87.8 bits (216), Expect = 5e-18, Method: Compositional matrix adjust. Identities = 84/299 (28%), Positives = 136/299 (45%), Gaps = 45/299 (15%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVR--VQTGEEGMPLSTIREVAVLRHL 68 + +E +G+G++GKVF A + K +F A+K ++ V ++ + T+ E VL Sbjct: 19 EDFELHKMLGKGSFGKVFLA-EFKKTNQFFAIKALKKDVVLMDDDVE-CTMVEKRVLSL- 75 Query: 69 ETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMF 127 +EHP + +F CT + L V E+++ DL ++ + + T Sbjct: 76 -AWEHPFLTHMF--CTFQTKEN---LFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAA-- 127 Query: 128 QLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVV-TLWYR 186 +++ GL FLHS +V+RDLK NIL+ G IK+ADFG+ + A T+ T Y Sbjct: 128 EIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNEFCGTPDYI 187 Query: 187 APEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRD 246 APE+LL Y VD WS G + EM + F G + Sbjct: 188 APEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDE---------------------- 225 Query: 247 VALPRQAFHS-KSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSAL-SHPYFQDL 303 + FHS + P + +++ KDLL+K P KR+ + HP F+++ Sbjct: 226 ----EELFHSIRMDNPF--YPRWLEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFREI 278 >4AF3-A nrPDB Length = 292 Score = 87.8 bits (216), Expect = 5e-18, Method: Compositional matrix adjust. Identities = 81/307 (26%), Positives = 143/307 (46%), Gaps = 47/307 (15%) Query: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRV-RVQTGEEGMPLSTIREVAVLRHLETF 71 +E +G+G +G V+ AR+ K VALK + + Q +EG+ RE+ + HL Sbjct: 25 FEIGRPLGKGKFGNVYLARE-KKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLH-- 81 Query: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQLL 130 HPN++RL++ R ++ L+ E+ + +L L K + +M +L Sbjct: 82 -HPNILRLYNYFYDRR-----RIYLILEYAPRGELYKELQK--SCTFDEQRTATIMEELA 133 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEV 190 L + H +V+HRD+KP+N+L+ G++K+ADFG + +++ + ++ TL Y PE+ Sbjct: 134 DALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWS-VHAPSLRRKTMCGTLDYLPPEM 192 Query: 191 LLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALP 250 + + VDLW +G + E+ P F +S + +I+ V D+ Sbjct: 193 IEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKV-----------DL--- 238 Query: 251 RQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENL 310 KF + +DL+ K L NP++R+ +HP+ + N Sbjct: 239 -------------KFPASVPTGAQDLISKLLRHNPSERLPLAQVSAHPW------VRANS 279 Query: 311 DSHLPPS 317 LPPS Sbjct: 280 RRVLPPS 286 >1ZXE-A nrPDB Length = 303 Score = 87.8 bits (216), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 73/252 (28%), Positives = 118/252 (46%), Gaps = 33/252 (13%) Query: 7 CRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLR 66 R +E +A +G+GA+G+V KAR+ + R+ A+K++R T E+ LSTI +L Sbjct: 2 LRYASDFEEIAVLGQGAFGQVVKARNALDS-RYYAIKKIR-HTEEK---LSTILSEVML- 55 Query: 67 HLETFEHPNVVRLFD--------VCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVP 118 L + H VVR + V ++ +++ L + E+ + L Sbjct: 56 -LASLNHQYVVRYYAAWLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQ 114 Query: 119 TETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQM---- 174 + + Q+L L ++HS ++HR+LKP NI + S +K+ DFGLA+ + Sbjct: 115 RDEYWRLFRQILEALSYIHSQGIIHRNLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILK 174 Query: 175 -----------ALTSVVVTLWYRAPEVLLQSS-YATPVDLWSVGCIFAEMFRRKPLFRGS 222 LTS + T Y A EVL + Y +D++S+G IF EM P G Sbjct: 175 LDSQNLPGSSDNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMIY--PFSTGM 232 Query: 223 SDVDQLGKILDV 234 V+ L K+ V Sbjct: 233 ERVNILKKLRSV 244 >5ES1-A nrPDB Length = 328 Score = 87.8 bits (216), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 61/200 (30%), Positives = 98/200 (49%), Gaps = 13/200 (6%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETF 71 Y + IG+G + KV AR + G R VA+K + REV +++ L Sbjct: 16 NYRLLRTIGKGNFAKVKLARHILTG-REVAIKIIDKTQLNPSSLQKLFREVRIMKGLN-- 72 Query: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQLL 130 HPN+V+LF+V +T L LV E+ ++ YL V + + + Q++ Sbjct: 73 -HPNIVKLFEVIETEKT-----LYLVMEYASAGEVFDYL--VSHGRMKEKEARAKFRQIV 124 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEV 190 + + H +VHRDLK +N+L+ + IK+ADFG + ++ L + + Y APE+ Sbjct: 125 SAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPEL 184 Query: 191 LLQSSYATP-VDLWSVGCIF 209 Y P VD+WS+G I Sbjct: 185 FQGKKYDGPEVDIWSLGVIL 204 >2QNJ-A nrPDB Length = 328 Score = 87.4 bits (215), Expect = 7e-18, Method: Compositional matrix adjust. Identities = 64/213 (30%), Positives = 106/213 (49%), Gaps = 20/213 (9%) Query: 5 GLCRADQQ-----YECVAEIGEGAYGKVFKARDLKNGGRFVALKRV-RVQTGEEGMPLST 58 G +D+Q Y + IG+G + KV AR + G R VA+K + + Q P S Sbjct: 1 GAMGSDEQPHIGNYRLLKTIGKGNFAKVKLARHILTG-REVAIKIIDKTQLN----PTSL 55 Query: 59 IREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGV 117 + +R ++ HPN+V+LF+V +T L L+ E+ ++ YL V + Sbjct: 56 QKLFREVRIMKILNHPNIVKLFEVIETEKT-----LYLIMEYASGGEVFDYL--VAHGRM 108 Query: 118 PTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALT 177 + + Q++ + + H R+VHRDLK +N+L+ + IK+ADFG + ++ L Sbjct: 109 KEKEARSKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLD 168 Query: 178 SVVVTLWYRAPEVLLQSSYATP-VDLWSVGCIF 209 + + Y APE+ Y P VD+WS+G I Sbjct: 169 TFCGSPPYAAPELFQGKKYDGPEVDVWSLGVIL 201 >4PL5-B nrPDB Length = 435 Score = 87.4 bits (215), Expect = 8e-18, Method: Compositional matrix adjust. Identities = 91/300 (30%), Positives = 136/300 (45%), Gaps = 52/300 (17%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVR 78 +G GA G + N R VA+KR+ + REV +LR E+ EHPNV+R Sbjct: 35 LGHGAEGTIVYKGMFDN--RDVAVKRILPECFS-----FADREVQLLR--ESDEHPNVIR 85 Query: 79 LFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHS 138 F CT DR+ + + E L Y+++ + E I ++ Q GL LHS Sbjct: 86 YF--CT--EKDRQFQY-IAIELCAATLQEYVEQKDFAHLGLEPIT-LLHQTTSGLAHLHS 139 Query: 139 HRVVHRDLKPQNILVT---SSGQIK--LADFGLARI-----YSFQMALTSVVVTLWYRAP 188 +VHRDLKP NIL++ + G+IK ++DFGL + +SF + V T + AP Sbjct: 140 LNIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRR-SGVPGTEGWIAP 198 Query: 189 EVLLQSSYATP---VDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPR 245 E+L + P VD++S GC+F + G S Q +L L Sbjct: 199 EMLSEDCKDNPTYTVDIFSAGCVFYYVISEGYHPFGKSLQRQANILLGACNL-------- 250 Query: 246 DVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLER 305 FHS + D + ++L+ K + +P +R SA L HP+F LE+ Sbjct: 251 ------DCFHSDKHE---------DVIARELIEKMIAMDPQQRPSAKHVLKHPFFWSLEK 295 >3HMP-A nrPDB Length = 342 Score = 87.4 bits (215), Expect = 8e-18, Method: Compositional matrix adjust. Identities = 83/306 (27%), Positives = 133/306 (43%), Gaps = 55/306 (17%) Query: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 Y + +IG G KVF+ L + A+K V ++ + S E+A L L+ + Sbjct: 58 YSILKQIGSGGSSKVFQV--LNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQ--Q 113 Query: 73 HPN-VVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLR 131 H + ++RL+D + + +V E + DL ++L K + + K +L Sbjct: 114 HSDKIIRLYDYEITDQY-----IYMVMECGNIDLNSWLKK--KKSIDPWERKSYWKNMLE 166 Query: 132 GLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVV-----TLWYR 186 + +H H +VH DLKP N L+ G +KL DFG+A Q TSVV T+ Y Sbjct: 167 AVHTIHQHGIVHSDLKPANFLIV-DGMLKLIDFGIAN--QMQPDTTSVVKDSQVGTVNYM 223 Query: 187 APEVLLQSSYA-----------TPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVI 235 PE + S + D+WS+GCI M K F+ ++Q+ K+ +I Sbjct: 224 PPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ--QIINQISKLHAII 281 Query: 236 GLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSAL 295 E ++P +P + +D+L CL +P +RIS L Sbjct: 282 DPNHEIEFPD---IPEKDL-------------------QDVLKCCLKRDPKQRISIPELL 319 Query: 296 SHPYFQ 301 +HPY Q Sbjct: 320 AHPYVQ 325 >6GVJ-A nrPDB Length = 429 Score = 87.4 bits (215), Expect = 8e-18, Method: Compositional matrix adjust. Identities = 86/306 (28%), Positives = 132/306 (43%), Gaps = 55/306 (17%) Query: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 Y + +IG G KVF+ L + A+K V ++ + S E+A L L+ Sbjct: 146 YSILKQIGSGGSSKVFQV--LNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHS 203 Query: 73 HPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRG 132 ++RL+D TD+ + +V E + DL ++L K + + K +L Sbjct: 204 D-KIIRLYDY---EITDQ--YIYMVMECGNIDLNSWLKK--KKSIDPWERKSYWKNMLEA 255 Query: 133 LDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVV-----TLWYRA 187 + +H H +VH DLKP N L+ G +KL DFG+A Q TSVV T+ Y Sbjct: 256 VHTIHQHGIVHSDLKPANFLIV-DGMLKLIDFGIAN--QMQPDTTSVVKDSQVGTVNYMP 312 Query: 188 PEVLLQSSYA-----------TPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIG 236 PE + S + D+WS+GCI M K F+ ++Q+ K+ +I Sbjct: 313 PEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ--QIINQISKLHAIID 370 Query: 237 LPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELG-KDLLLKCLTFNPAKRISAYSAL 295 E ++P DI E +D+L CL +P +RIS L Sbjct: 371 PNHEIEFP-----------------------DIPEKDLQDVLKCCLKRDPKQRISIPELL 407 Query: 296 SHPYFQ 301 +HPY Q Sbjct: 408 AHPYVQ 413 >3LM0-A nrPDB Length = 327 Score = 87.0 bits (214), Expect = 9e-18, Method: Compositional matrix adjust. Identities = 75/289 (25%), Positives = 130/289 (44%), Gaps = 37/289 (12%) Query: 18 EIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVV 77 E+G G + V + K+ G+ A K ++ + + + E+AVL ++ P V+ Sbjct: 36 ELGRGKFAVVRQCIS-KSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELAKSC--PRVI 92 Query: 78 RLFDVCTVSRTDRETKLTLVFEHV--DQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDF 135 L +V + +++ L+ E+ + + L ++ E + I+ ++ Q+L G+ + Sbjct: 93 NLHEV-----YENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIR-LIKQILEGVYY 146 Query: 136 LHSHRVVHRDLKPQNILVTSS---GQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLL 192 LH + +VH DLKPQNIL++S G IK+ DFG++R L ++ T Y APE+L Sbjct: 147 LHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACELREIMGTPEYLAPEILN 206 Query: 193 QSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQ 252 T D+W++G I + F G + + I V +V + Sbjct: 207 YDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQV-----------NVDYSEE 255 Query: 253 AFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQ 301 F S + +L D + L NP KR +A LSH + Q Sbjct: 256 TFSS------------VSQLATDFIQSLLVKNPEKRPTAEICLSHSWLQ 292 >4FZF-B nrPDB Length = 283 Score = 87.0 bits (214), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 59/214 (27%), Positives = 117/214 (54%), Gaps = 13/214 (6%) Query: 5 GLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAV 64 + ++ + + IG+G++G+VFK D + + VA+K + ++ E+ + +E+ V Sbjct: 2 AMADPEELFTKLERIGKGSFGEVFKGIDNRTQ-QVVAIKIIDLEEAEDEIEDIQ-QEITV 59 Query: 65 LRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKD 124 L ++ V + + + +KL ++ E++ + LD + I Sbjct: 60 LSQCDS---SYVTKYYGSYL-----KGSKLWIIMEYLGGG--SALDLLRAGPFDEFQIAT 109 Query: 125 MMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLA-RIYSFQMALTSVVVTL 183 M+ ++L+GLD+LHS + +HRD+K N+L++ G +KLA FG+A ++ Q+ + V T Sbjct: 110 MLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLAAFGVAGQLTDTQIKRNTFVGTP 169 Query: 184 WYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKP 217 ++ APEV+ QS+Y + D+WS+G E+ + +P Sbjct: 170 FWMAPEVIQQSAYDSKADIWSLGITAIELAKGEP 203 >4CSV-A nrPDB Length = 275 Score = 86.7 bits (213), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 60/219 (27%), Positives = 112/219 (51%), Gaps = 21/219 (9%) Query: 18 EIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLST-IREVAVLRHLETFEHPNV 76 ++G G +G+V++ + +N VA+K ++ T M + ++E +++ L+ HPN+ Sbjct: 18 KLGSGQFGEVYEGK-WRNYNIEVAVKTLKEGT----MSVEEFLQEAQIMKKLK---HPNL 69 Query: 77 VRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQLLRGLDF 135 V+L+ VCT +E + ++ E++ L YL V + + DM Q+ G+ + Sbjct: 70 VQLYGVCT-----KEPPIYIITEYMSHGSLLDYLRDCEGHTVNAQALLDMAAQVASGMAY 124 Query: 136 LHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQ--MALTSVVVTLWYRAPEVLLQ 193 L S +HRDL +N LV + +K+ADFGLAR+ + A + + APE + Sbjct: 125 LESQNFIHRDLAARNCLVGENNVVKVADFGLARLINEDEYTARAGAKFPIKWTAPEAISY 184 Query: 194 SSYATPVDLWSVGCIFAEMFRRK----PLFRGSSDVDQL 228 + ++ D+W+ G + E+F P GS ++Q+ Sbjct: 185 NRFSIKSDVWAFGILLWEIFTYGQVPYPGMSGSEVIEQV 223 >4PDS-A nrPDB Length = 347 Score = 86.7 bits (213), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 82/301 (27%), Positives = 136/301 (45%), Gaps = 55/301 (18%) Query: 19 IGEGAYGKVFKARDLKNGGRFVA--LKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNV 76 +G+GA+ V KA + G F + + +V +G+ RE+ VL+ L HP + Sbjct: 39 VGQGAFATVKKAIERTTGKTFSVKIISKRKVIGNMDGV----TRELEVLQKLN---HPRI 91 Query: 77 VRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQLLRGLDF 135 VRL D E+ +V E V DL ++ V + +++ Q+L + + Sbjct: 92 VRLKGFYE----DTES-YYMVMEFVSGGDLMDFV--AAHGAVGEDAGREISRQILTAIKY 144 Query: 136 LHSHRVVHRDLKPQNILVTSSGQ--IKLADFGLARIYSFQMALTSVVVTLWYRAPEVLL- 192 +HS + HRDLKP NIL+ +K+ FGLA++ + + TL Y APEV+ Sbjct: 145 IHSMGISHRDLKPDNILIEQDDPVLVKITAFGLAKVQGNGSFMKTFCGTLAYVAPEVIRG 204 Query: 193 ------------QSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGE 240 ++ Y++ VD+WS+GC+ + F GS+ DQL K Sbjct: 205 KDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQ-DQLYK---------- 253 Query: 241 EDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 + R ++H P++ F I E +D + L +P R +A AL+HP+ Sbjct: 254 -------QIGRGSYHEG---PLKDF--RISEEARDFIDSLLQVDPNNRSTAAKALNHPWI 301 Query: 301 Q 301 + Sbjct: 302 K 302 >2PSQ-A nrPDB Length = 370 Score = 86.7 bits (213), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 64/219 (29%), Positives = 111/219 (50%), Gaps = 32/219 (14%) Query: 19 IGEGAYGKVFKA------RDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 +GEG +G+V A +D VA+K ++ E+ + + E+ +++ + + Sbjct: 89 LGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLS-DLVSEMEMMKMIG--K 145 Query: 73 HPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPG---------VPTE-- 120 H N++ L CT ++ L ++ E+ + +L YL PG VP E Sbjct: 146 HKNIINLLGACT-----QDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQM 200 Query: 121 TIKDMM---FQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYS---FQM 174 T KD++ +QL RG+++L S + +HRDL +N+LVT + +K+ADFGLAR + + Sbjct: 201 TFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYK 260 Query: 175 ALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMF 213 T+ + + + APE L Y D+WS G + E+F Sbjct: 261 KTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIF 299 >5EG3-A nrPDB Length = 334 Score = 86.7 bits (213), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 65/219 (29%), Positives = 111/219 (50%), Gaps = 32/219 (14%) Query: 19 IGEGAYGKVFKA------RDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 +GEGA+G+V A +D VA+K ++ E+ + + E+ +++ + + Sbjct: 43 LGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLS-DLVSEMEMMKMIG--K 99 Query: 73 HPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPG---------VPTE-- 120 H N++ L CT ++ L ++ + + +L YL PG VP E Sbjct: 100 HKNIINLLGACT-----QDGPLYVIVAYASKGNLREYLRARRPPGMELSPDINRVPEEQM 154 Query: 121 TIKDMM---FQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYS---FQM 174 T KD++ +QL RG+++L S + +HRDL +N+LVT + +K+ADFGLAR + F Sbjct: 155 TFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDFFK 214 Query: 175 ALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMF 213 T+ + + + APE L Y D+WS G + E+F Sbjct: 215 ETTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIF 253 >2BRG-A nrPDB Length = 297 Score = 86.7 bits (213), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 60/207 (28%), Positives = 105/207 (50%), Gaps = 15/207 (7%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 + ++ V +GEGAYG+V A + + VA+K V ++ + P + +E+ + + L Sbjct: 7 EDWDLVQTLGEGAYGEVQLAVN-RVTEEAVAVKIVDMKRAVD-CPENIKKEICINKMLN- 63 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130 H NVV+ + RE + +F + P+ G+P + QL+ Sbjct: 64 --HENVVKFYG------HRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLM 115 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSF---QMALTSVVVTLWYRA 187 G+ +LH + HRD+KP+N+L+ +K++DFGLA ++ + + L + TL Y A Sbjct: 116 AGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVA 175 Query: 188 PEVLLQSSY-ATPVDLWSVGCIFAEMF 213 PE+L + + A PVD+WS G + M Sbjct: 176 PELLKRREFHAEPVDVWSCGIVLTAML 202 >4CFF-A nrPDB Length = 571 Score = 86.7 bits (213), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 63/197 (31%), Positives = 101/197 (51%), Gaps = 12/197 (6%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVR 78 +G G +GKV K + + G VA+K + Q + I+ +++L+ F HP++++ Sbjct: 41 LGVGTFGKV-KIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKRE--IQNLKLFRHPHIIK 97 Query: 79 LFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQ-LLRGLDFLH 137 L+ V + T +V E+V D + + G E +FQ +L +D+ H Sbjct: 98 LYQVISTP-----TDFFMVMEYVSGG--ELFDYICKHGRVEEMEARRLFQQILSAVDYCH 150 Query: 138 SHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYA 197 H VVHRDLKP+N+L+ + K+ADFGL+ + S L + + Y APEV+ YA Sbjct: 151 RHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYA 210 Query: 198 TP-VDLWSVGCIFAEMF 213 P VD+WS G I + Sbjct: 211 GPEVDIWSCGVILYALL 227 >5KZ7-A nrPDB Length = 346 Score = 86.7 bits (213), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 63/208 (30%), Positives = 102/208 (49%), Gaps = 18/208 (8%) Query: 9 ADQQ-----YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVA 63 AD+Q Y + IG+G + KV AR + G + VA+K + REV Sbjct: 26 ADEQPHIGNYRLLKTIGKGNFAKVKLARHILTG-KEVAVKIIDKTQLNSSSLQKLFREVR 84 Query: 64 VLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETI 122 +++ HPN+V+LF+V +T L LV E+ ++ YL V + + Sbjct: 85 IMK---VLNHPNIVKLFEVIETEKT-----LYLVMEYASGGEVFDYL--VAHGRMKEKEA 134 Query: 123 KDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVT 182 + Q++ + + H +VHRDLK +N+L+ + IK+ADFG + ++F L + + Sbjct: 135 RAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGS 194 Query: 183 LWYRAPEVLLQSSYATP-VDLWSVGCIF 209 Y APE+ Y P VD+WS+G I Sbjct: 195 PPYAAPELFQGKKYDGPEVDVWSLGVIL 222 >5EZV-A nrPDB Length = 560 Score = 86.3 bits (212), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 63/197 (31%), Positives = 101/197 (51%), Gaps = 12/197 (6%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVR 78 +G G +GKV K + + G VA+K + Q + I+ +++L+ F HP++++ Sbjct: 36 LGVGTFGKV-KIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKRE--IQNLKLFRHPHIIK 92 Query: 79 LFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQ-LLRGLDFLH 137 L+ V + T +V E+V D + + G E +FQ +L +D+ H Sbjct: 93 LYQVISTP-----TDFFMVMEYVSGG--ELFDYICKHGRVEEMEARRLFQQILSAVDYCH 145 Query: 138 SHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYA 197 H VVHRDLKP+N+L+ + K+ADFGL+ + S L + + Y APEV+ YA Sbjct: 146 RHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYA 205 Query: 198 TP-VDLWSVGCIFAEMF 213 P VD+WS G I + Sbjct: 206 GPEVDIWSCGVILYALL 222 >3LLT-A nrPDB Length = 360 Score = 85.9 bits (211), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 81/338 (23%), Positives = 134/338 (39%), Gaps = 57/338 (16%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLE 69 + + + ++G+G +G+V + + N ++ A+K VR + S E +L+ ++ Sbjct: 34 NNAFLVIRKMGDGTFGRVLLCQHIDNK-KYYAVKVVR---NIKKYTRSAKIEADILKKIQ 89 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQL 129 + N + D + L+FE + L + + G E IK ++ Sbjct: 90 NDDINNNNIVKYHGKFMYYDH---MCLIFEPLGPSLYEIITRNNYNGFHIEDIKLYCIEI 146 Query: 130 LRGLDFLHSHRVVHRDLKPQNILV-------------------------TSSGQIKLADF 164 L+ L++L + H DLKP+NIL+ T S IKL DF Sbjct: 147 LKALNYLRKMSLTHTDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRTKSTGIKLIDF 206 Query: 165 GLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSD 224 G A S S++ T YRAPEV+L + D+WS GC+ AE++ LFR Sbjct: 207 GCATFKSDYHG--SIINTRQYRAPEVILNLGWDVSSDMWSFGCVLAELYTGSLLFRTHEH 264 Query: 225 VDQLGKILDVIG-LPGEE--------------------DWPRDVALPRQAFHSKSAQPIE 263 ++ L + +I +P WP + + H K P+ Sbjct: 265 MEHLAMMESIIQPIPKNMLYEATKTNGSKYVNKDELKLAWPENASSINSIKHVKKCLPLY 324 Query: 264 KFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQ 301 K + EL D L L +P R S L H + + Sbjct: 325 KIIK--HELFCDFLYSILQIDPTLRPSPAELLKHKFLE 360 >3GQL-A nrPDB Length = 326 Score = 85.5 bits (210), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 64/219 (29%), Positives = 111/219 (50%), Gaps = 32/219 (14%) Query: 19 IGEGAYGKVFKA------RDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 +GEGA+G+V A +D N VA+K ++ E+ + I E+ +++ + + Sbjct: 36 LGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLS-DLISEMEMMKMIG--K 92 Query: 73 HPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGV---------PTETI 122 H N++ L CT ++ L ++ E+ + +L YL PG+ P E + Sbjct: 93 HKNIINLLGACT-----QDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQL 147 Query: 123 --KDMM---FQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLAR---IYSFQM 174 KD++ +Q+ RG+++L S + +HRDL +N+LVT +K+ADFGLAR + Sbjct: 148 SSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYK 207 Query: 175 ALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMF 213 T+ + + + APE L Y D+WS G + E+F Sbjct: 208 KTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIF 246 >3FME-A nrPDB Length = 290 Score = 85.5 bits (210), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 79/296 (26%), Positives = 134/296 (45%), Gaps = 44/296 (14%) Query: 14 ECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQ-TGEEGMPLSTIREVAVLRHLETFE 72 E + E+G GAYG V K R + +G + +A+KR+R +E L +++ + T + Sbjct: 10 EPIMELGRGAYGVVEKMRHVPSG-QIMAVKRIRATVNSQEQKRLLMDLDIS----MRTVD 64 Query: 73 HPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPG--VPTETIKDMMFQLL 130 P V + RE + + E +D L + +V + G +P + + + ++ Sbjct: 65 CPFTVTFYGALF-----REGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIV 119 Query: 131 RGLDFLHSH-RVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPE 189 + L+ LHS V+HRD+KP N+L+ + GQ+K+ DFG++ +A Y APE Sbjct: 120 KALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDDVAKDIDAGCKPYMAPE 179 Query: 190 ----VLLQSSYATPVDLWSVGCIFAEM-FRRKPLFRGSSDVDQLGKILDVIGLPGEEDWP 244 L Q Y+ D+WS+G E+ R P + QL +++ EE P Sbjct: 180 RINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVV-------EEPSP 232 Query: 245 RDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 + LP F + +FV D +CL N +R + + HP+F Sbjct: 233 Q---LPADKFSA-------EFV--------DFTSQCLKKNSKERPTYPELMQHPFF 270 >6HV0-A nrPDB Length = 416 Score = 85.5 bits (210), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 91/300 (30%), Positives = 136/300 (45%), Gaps = 52/300 (17%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVR 78 +G GA G + N R VA+KR+ E + REV +LR E+ EHPNV+R Sbjct: 16 LGHGAEGTIVYRGMFDN--RDVAVKRIL----PECFSFAD-REVQLLR--ESDEHPNVIR 66 Query: 79 LFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHS 138 F CT DR+ + + E L Y+++ + E I ++ Q GL LHS Sbjct: 67 YF--CT--EKDRQFQY-IAIELCAATLQEYVEQKDFAHLGLEPIT-LLQQTTSGLAHLHS 120 Query: 139 HRVVHRDLKPQNILVT---SSGQIK--LADFGLARI-----YSFQMALTSVVVTLWYRAP 188 +VHRDLKP NIL++ + G+IK ++DFGL + +SF + V T + AP Sbjct: 121 LNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRR-SGVPGTEGWIAP 179 Query: 189 EVLLQSSYATP---VDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPR 245 E+L + P VD++S GC+F + G S Q +L L Sbjct: 180 EMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANILLGACSL-------- 231 Query: 246 DVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLER 305 H + + D + ++L+ K + +P KR SA L HP+F LE+ Sbjct: 232 ------DCLHPEKHE---------DVIARELIEKMIAMDPQKRPSAKHVLKHPFFWSLEK 276 >5AP3-A nrPDB Length = 313 Score = 85.5 bits (210), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 85/306 (27%), Positives = 134/306 (43%), Gaps = 55/306 (17%) Query: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 Y + +IG G KVF+ L + A+K V ++ + S E+A L L+ + Sbjct: 30 YSILKQIGSGGSSKVFQV--LNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQ--Q 85 Query: 73 HPN-VVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLR 131 H + ++RL+D TD+ + +V E + DL +L K + + K +L Sbjct: 86 HSDKIIRLYDY---EITDQ--YIYMVMECGNIDLNGWLKK--KKSIDPWERKSYWKNMLE 138 Query: 132 GLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVV-----TLWYR 186 + +H H +VH DLKP N L+ G +KL DFG+A Q TSVV T+ Y Sbjct: 139 AVHTIHQHGIVHSDLKPANFLIV-DGMLKLIDFGIAN--QMQPDTTSVVKDSQVGTVNYM 195 Query: 187 APEVLLQSSYA-----------TPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVI 235 PE + S + D+WS+GCI M K F+ ++Q+ K+ +I Sbjct: 196 PPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ--QIINQISKLHAII 253 Query: 236 GLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSAL 295 E ++P +P + +D+L CL +P +RIS L Sbjct: 254 DPNHEIEFPD---IPEKDL-------------------QDVLKCCLKRDPKQRISIPELL 291 Query: 296 SHPYFQ 301 +HPY Q Sbjct: 292 AHPYVQ 297 >4D28-A nrPDB Length = 446 Score = 85.1 bits (209), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 66/202 (32%), Positives = 102/202 (50%), Gaps = 15/202 (7%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTI-REVAVLRHLET 70 +YE IGEG + KV AR+ G VA+K + T + + I RE+++++ Sbjct: 10 KYEVGRTIGEGTFAKVKFARNTDTGDN-VAIKIMAKSTILKNRMVDQIKREISIMK---I 65 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQ-L 129 HPN+VRL++V ++K+ +V E V D++ G E FQ L Sbjct: 66 VRHPNIVRLYEVLA-----SKSKIYIVLEFVTGG--ELFDRIVHKGRLKEDESRKYFQQL 118 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMA-LTSVVVTLWYRAP 188 + + HS V HRDLKP+N+L+ ++G +K++DFGL+ + + L T Y AP Sbjct: 119 VDAVAHCHSKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLNDTCGTPNYVAP 178 Query: 189 EVLLQSSY-ATPVDLWSVGCIF 209 EVL Y + D+WS G I Sbjct: 179 EVLSGQGYDGSAADIWSCGVIL 200 >3ORP-A nrPDB Length = 311 Score = 85.1 bits (209), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 75/281 (26%), Positives = 128/281 (45%), Gaps = 32/281 (11%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETF 71 +YE +G G +V ARDL++ R VA+K +R + P +R ++ Sbjct: 13 RYELGEILGFGGMSEVHLARDLRDH-RDVAVKVLRADLARD--PSFYLRFRREAQNAAAL 69 Query: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLR 131 HP +V ++D + T +V E+VD + P P I +++ + Sbjct: 70 NHPAIVAVYDTGE-AETPAGPLPYIVMEYVDGVTLRDIVHTEGPMTPKRAI-EVIADACQ 127 Query: 132 GLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLAR-IYSFQMALT---SVVVTLWYRA 187 L+F H + ++HRD+KP NI+++++ +K+ DFG+AR I ++T +V+ T Y + Sbjct: 128 ALNFSHQNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGTAQYLS 187 Query: 188 PEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDV 247 PE S D++S+GC+ E+ +P F G S V + + R+ Sbjct: 188 PEQARGDSVDARSDVYSLGCVLYEVLTGEPPFTGDSPVSVAYQHV------------RED 235 Query: 248 ALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKR 288 +P A H E D+D ++LK L NP R Sbjct: 236 PIPPSARH-------EGLSADLDA----VVLKALAKNPENR 265 >3TT0-A nrPDB Length = 382 Score = 84.7 bits (208), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 64/219 (29%), Positives = 111/219 (50%), Gaps = 32/219 (14%) Query: 19 IGEGAYGKVFKA------RDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 +GEGA+G+V A +D N VA+K ++ E+ + I E+ +++ + + Sbjct: 77 LGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLS-DLISEMEMMKMIG--K 133 Query: 73 HPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGV---------PTETI 122 H N++ L CT ++ L ++ E+ + +L YL PG+ P E + Sbjct: 134 HKNIINLLGACT-----QDGPLYVIVEYASKGNLREYLQARRPPGLEYSYNPSHNPEEQL 188 Query: 123 --KDMM---FQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLAR---IYSFQM 174 KD++ +Q+ RG+++L S + +HRDL +N+LVT +K+ADFGLAR + Sbjct: 189 SSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYK 248 Query: 175 ALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMF 213 T+ + + + APE L Y D+WS G + E+F Sbjct: 249 KTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIF 287 >2ZMD-A nrPDB Length = 390 Score = 84.7 bits (208), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 82/306 (26%), Positives = 132/306 (43%), Gaps = 55/306 (17%) Query: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 Y + +IG G KVF+ L + A+K V ++ + S E+A L L+ + Sbjct: 58 YSILKQIGSGGSSKVFQV--LNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQ--Q 113 Query: 73 HPN-VVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLR 131 H + ++RL+D + + +V E + DL ++L K + + K +L Sbjct: 114 HSDKIIRLYDYEITDQY-----IYMVMECGNIDLNSWLKK--KKSIDPWERKSYWKNMLE 166 Query: 132 GLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVV-----TLWYR 186 + +H H +VH DLKP N L+ G +KL DFG+A Q TSVV + Y Sbjct: 167 AVHTIHQHGIVHSDLKPANFLIV-DGMLKLIDFGIAN--QMQPDTTSVVKDSQVGAVNYM 223 Query: 187 APEVLLQSSYA-----------TPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVI 235 PE + S + D+WS+GCI M K F+ ++Q+ K+ +I Sbjct: 224 PPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ--QIINQISKLHAII 281 Query: 236 GLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSAL 295 E ++P +P + +D+L CL +P +RIS L Sbjct: 282 DPNHEIEFPD---IPEKDL-------------------QDVLKCCLKRDPKQRISIPELL 319 Query: 296 SHPYFQ 301 +HPY Q Sbjct: 320 AHPYVQ 325 >3HKO-A nrPDB Length = 345 Score = 84.7 bits (208), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 85/343 (24%), Positives = 137/343 (39%), Gaps = 79/343 (23%) Query: 6 LCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFV-ALKRVRVQTGEEGMPLSTIREVAV 64 L ++Y IG+G+YG V A ++N R + A+K + + P R Sbjct: 21 LLELQKKYHLKGAIGQGSYGVVRVA--IENQTRAIRAIKIMNKNKIRQINPKDVERIKTE 78 Query: 65 LRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFE-----HVDQDLTTYLDK-------- 111 +R ++ HPN+ RL++V + E + LV E H+ L ++D Sbjct: 79 VRLMKKLHHPNIARLYEV-----YEDEQYICLVMELCHGGHLLDKLNVFIDDSTGKCAMD 133 Query: 112 ------VPEPGVPTETIK--------------------DMMFQLLRGLDFLHSHRVVHRD 145 P P E I ++M Q+ L +LH+ + HRD Sbjct: 134 VVKTQICPCPECNEEAINGSIHGFRESLDFVQREKLISNIMRQIFSALHYLHNQGICHRD 193 Query: 146 LKPQNILVTS--SGQIKLADFGLAR-IYSFQ----MALTSVVVTLWYRAPEVL--LQSSY 196 +KP+N L ++ S +IKL DFGL++ Y +T+ T ++ APEVL SY Sbjct: 194 IKPENFLFSTNKSFEIKLVDFGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEVLNTTNESY 253 Query: 197 ATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHS 256 D WS G + + F G +D D + ++L+ + F + Sbjct: 254 GPKCDAWSAGVLLHLLLMGAVPFPGVNDADTISQVLN----------------KKLCFEN 297 Query: 257 KSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPY 299 + + L +DLL L N +R A AL HP+ Sbjct: 298 PNYNV-------LSPLARDLLSNLLNRNVDERFDAMRALQHPW 333 >2W1I-A nrPDB Length = 326 Score = 84.7 bits (208), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 62/210 (29%), Positives = 108/210 (51%), Gaps = 25/210 (11%) Query: 16 VAEIGEGAYGKVFKARD---LKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 + ++G+G +G V R N G VA+K+++ T E RE+ +L+ L+ Sbjct: 46 LQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFE--REIEILKSLQ--- 100 Query: 73 HPNVVRLFDVC-TVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMF--Q 128 H N+V+ VC + R + L L+ E++ L YL K E + IK + + Q Sbjct: 101 HDNIVKYKGVCYSAGRRN----LKLIMEYLPYGSLRDYLQKHKER---IDHIKLLQYTSQ 153 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYS-----FQMALTSVVVTL 183 + +G+++L + R +HRDL +NILV + ++K+ DFGL ++ +++ Sbjct: 154 ICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIF 213 Query: 184 WYRAPEVLLQSSYATPVDLWSVGCIFAEMF 213 WY APE L +S ++ D+WS G + E+F Sbjct: 214 WY-APESLTESKFSVASDVWSFGVVLYELF 242 >3IO7-A nrPDB Length = 313 Score = 84.7 bits (208), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 62/210 (29%), Positives = 108/210 (51%), Gaps = 25/210 (11%) Query: 16 VAEIGEGAYGKVFKARD---LKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 + ++G+G +G V R N G VA+K+++ T E RE+ +L+ L+ Sbjct: 33 LQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFE--REIEILKSLQ--- 87 Query: 73 HPNVVRLFDVC-TVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMF--Q 128 H N+V+ VC + R + L L+ E++ L YL K E + IK + + Q Sbjct: 88 HDNIVKYKGVCYSAGRRN----LKLIMEYLPYGSLRDYLQKHKER---IDHIKLLQYTSQ 140 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYS-----FQMALTSVVVTL 183 + +G+++L + R +HRDL +NILV + ++K+ DFGL ++ +++ Sbjct: 141 ICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIF 200 Query: 184 WYRAPEVLLQSSYATPVDLWSVGCIFAEMF 213 WY APE L +S ++ D+WS G + E+F Sbjct: 201 WY-APESLTESKFSVASDVWSFGVVLYELF 229 >2YZA-A nrPDB Length = 276 Score = 84.7 bits (208), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 63/197 (31%), Positives = 100/197 (50%), Gaps = 12/197 (6%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVR 78 +G G +GKV K + + G VA+K + Q + I+ +++L+ F HP++++ Sbjct: 19 LGVGTFGKV-KIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKRE--IQNLKLFRHPHIIK 75 Query: 79 LFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQ-LLRGLDFLH 137 L+ V + T +V E+V D + + G E +FQ +L +D+ H Sbjct: 76 LYQVISTP-----TDFFMVMEYVSGG--ELFDYICKHGRVEEMEARRLFQQILSAVDYCH 128 Query: 138 SHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYA 197 H VVHRDLKP+N+L+ + K+ADFGL+ + S L + Y APEV+ YA Sbjct: 129 RHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRDSCGSPNYAAPEVISGRLYA 188 Query: 198 TP-VDLWSVGCIFAEMF 213 P VD+WS G I + Sbjct: 189 GPEVDIWSCGVILYALL 205 >4UY9-A nrPDB Length = 323 Score = 84.3 bits (207), Expect = 7e-17, Method: Compositional matrix adjust. Identities = 66/216 (30%), Positives = 105/216 (48%), Gaps = 27/216 (12%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEE-GMPLSTIREVAVLRHLETFEHPNVV 77 IG G +GKV++A + G VA+K R E+ + +R+ A L +HPN++ Sbjct: 17 IGIGGFGKVYRAFWI---GDEVAVKAARHDPDEDISQTIENVRQEAKL--FAMLKHPNII 71 Query: 78 RLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKV-PEPGVPTETIKDMMFQLLRGLDFL 136 L VC +E L LV E L++V +P + + + Q+ RG+++L Sbjct: 72 ALRGVCL-----KEPNLCLVMEFAR---GGPLNRVLSGKRIPPDILVNWAVQIARGMNYL 123 Query: 137 HSHRVV---HRDLKPQNILVT--------SSGQIKLADFGLARIYSFQMALTSVVVTLWY 185 H +V HRDLK NIL+ S+ +K+ DFGLAR + +++ W Sbjct: 124 HDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWM 183 Query: 186 RAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRG 221 APEV+ S ++ D+WS G + E+ + FRG Sbjct: 184 -APEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRG 218 >4KIK-B nrPDB Length = 677 Score = 84.0 bits (206), Expect = 8e-17, Method: Compositional matrix adjust. Identities = 63/205 (30%), Positives = 97/205 (47%), Gaps = 11/205 (5%) Query: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 +E +G G +G V + + + G + +A+K+ R +E P + R ++ + Sbjct: 21 WEMKERLGTGGFGNVIRWHNQETGEQ-IAIKQCR----QELSPRNRERWCLEIQIMRRLT 75 Query: 73 HPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ--DLTTYLDKVPEP-GVPTETIKDMMFQL 129 HPNVV DV + L L+ Q DL YL++ G+ I ++ + Sbjct: 76 HPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDI 135 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQI---KLADFGLARIYSFQMALTSVVVTLWYR 186 L +LH +R++HRDLKP+NI++ Q K+ D G A+ TS V TL Y Sbjct: 136 ASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYL 195 Query: 187 APEVLLQSSYATPVDLWSVGCIFAE 211 APE+L Q Y VD WS G + E Sbjct: 196 APELLEQQKYTVTVDYWSFGTLAFE 220 >5WAX-A nrPDB Length = 310 Score = 84.0 bits (206), Expect = 8e-17, Method: Compositional matrix adjust. Identities = 79/296 (26%), Positives = 129/296 (43%), Gaps = 45/296 (15%) Query: 12 QYECVAEIGEGAYGKVFKARDLKN--GGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLE 69 +YE V +IG G +G AR ++N G+ VA+K + E G + + ++ H Sbjct: 12 RYELVRDIGSGNFGV---ARLMRNRADGQLVAVKYI-----ERGEKIDENVQREIINH-R 62 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQ- 128 + HPN++R +V T L +V E+ +++ G +E FQ Sbjct: 63 SLRHPNIIRFKEVILTP-----THLAIVMEYASGG--ELFERICNAGRFSEDEARFFFQQ 115 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILV--TSSGQIKLADFGLARIYSFQMALTSVVVTLWYR 186 L+ G+ + HS +V HRDLK +N L+ +++ ++K+ DFG ++ S V T Y Sbjct: 116 LISGVSYCHSMQVCHRDLKLENTLLDGSTAPRLKICDFGYSKSSVLHSQPKSTVGTPAYI 175 Query: 187 APEVLLQSSYATPV-DLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILD-VIGLPGEEDWP 244 APEVLL+ Y V D+WS G M F + K + ++G+ Sbjct: 176 APEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRILGV------- 228 Query: 245 RDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 ++P S Q DL+ + NPA RI+ +HP+F Sbjct: 229 -QYSIPDYVHISPECQ--------------DLISRIFVANPATRITIPEIRNHPWF 269 >5A46-A nrPDB Length = 386 Score = 84.0 bits (206), Expect = 9e-17, Method: Compositional matrix adjust. Identities = 63/219 (28%), Positives = 110/219 (50%), Gaps = 32/219 (14%) Query: 19 IGEGAYGKVFKA------RDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 +GEG +G+V A +D N VA+K ++ E+ + I E+ +++ + + Sbjct: 48 LGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLS-DLISEMEMMKMIG--K 104 Query: 73 HPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGV---------PTETI 122 H N++ L CT ++ L ++ E+ + +L YL PG+ P E + Sbjct: 105 HKNIINLLGACT-----QDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQL 159 Query: 123 --KDMM---FQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLAR---IYSFQM 174 KD++ +Q+ RG+++L S + +HRDL +N+LVT +K+ADFGLAR + Sbjct: 160 SSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYK 219 Query: 175 ALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMF 213 T+ + + + APE L Y D+WS G + E+F Sbjct: 220 KTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIF 258 >3DTC-A nrPDB Length = 271 Score = 83.6 bits (205), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 66/216 (30%), Positives = 105/216 (48%), Gaps = 27/216 (12%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEE-GMPLSTIREVAVLRHLETFEHPNVV 77 IG G +GKV++A + G VA+K R E+ + +R+ A L +HPN++ Sbjct: 15 IGIGGFGKVYRAFWI---GDEVAVKAARHDPDEDISQTIENVRQEAKL--FAMLKHPNII 69 Query: 78 RLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKV-PEPGVPTETIKDMMFQLLRGLDFL 136 L VC +E L LV E L++V +P + + + Q+ RG+++L Sbjct: 70 ALRGVCL-----KEPNLCLVMEFARGG---PLNRVLSGKRIPPDILVNWAVQIARGMNYL 121 Query: 137 HSHRVV---HRDLKPQNILVT--------SSGQIKLADFGLARIYSFQMALTSVVVTLWY 185 H +V HRDLK NIL+ S+ +K+ DFGLAR + +++ W Sbjct: 122 HDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGAYAWM 181 Query: 186 RAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRG 221 APEV+ S ++ D+WS G + E+ + FRG Sbjct: 182 -APEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRG 216 >1KOB-A nrPDB Length = 387 Score = 83.2 bits (204), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 73/308 (23%), Positives = 129/308 (41%), Gaps = 39/308 (12%) Query: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 Y+ + E+G GA+G V + + G FVA + T + E++++ L Sbjct: 53 YDILEELGSGAFGVVHRCVEKATGRVFVA---KFINTPYPLDKYTVKNEISIMNQLH--- 106 Query: 73 HPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRG 132 HP ++ L D + + ++ L+ E + + + + + M Q G Sbjct: 107 HPKLINLHDAF-----EDKYEMVLILEFLSGGELFDRIAAEDYKMSEAEVINYMRQACEG 161 Query: 133 LDFLHSHRVVHRDLKPQNILVTS--SGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEV 190 L +H H +VH D+KP+NI+ + + +K+ DFGLA + + T + APE+ Sbjct: 162 LKHMHEHSIVHLDIKPENIMCETKKASSVKIIDFGLATKLNPDEIVKVTTATAEFAAPEI 221 Query: 191 LLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALP 250 + + D+W++G + + F G D++ L + DW D Sbjct: 222 VDREPVGFYTDMWAIGVLGYVLLSGLSPFAGEDDLETLQNVKRC-------DWEFD---- 270 Query: 251 RQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENL 310 AF S S + KD + L P KR++ + AL HP+ L+ NL Sbjct: 271 EDAFSSVSPE------------AKDFIKNLLQKEPRKRLTVHDALEHPW---LKGDHSNL 315 Query: 311 DSHLPPSQ 318 S +P S+ Sbjct: 316 TSRIPSSR 323 >3UIU-A nrPDB Length = 306 Score = 82.8 bits (203), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 61/221 (27%), Positives = 102/221 (46%), Gaps = 37/221 (16%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVR 78 IG G +G+VFKA+ +G +V ++RV+ + REV L L+ H N+V Sbjct: 20 IGSGGFGQVFKAKHRIDGKTYV-IRRVKYNNEK------AEREVKALAKLD---HVNIVH 69 Query: 79 LFDVC----------------------TVSRTDRETKLTLVF---EHVDQD-LTTYLDKV 112 ++ C S+ +K +F E D+ L +++K Sbjct: 70 -YNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKR 128 Query: 113 PEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSF 172 + ++ Q+ +G+D++HS +++HRDLKP NI + + Q+K+ DFGL Sbjct: 129 RGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKN 188 Query: 173 QMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMF 213 T TL Y +PE + Y VDL+++G I AE+ Sbjct: 189 DGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELL 229 >3I6U-A nrPDB Length = 419 Score = 82.4 bits (202), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 79/306 (25%), Positives = 134/306 (43%), Gaps = 51/306 (16%) Query: 12 QYECVAEIGEGAYGKV---FKARDLKNGG-RFVALKRVRVQTGEEGMP-LSTIREVAVLR 66 +Y +G GA G+V F+ + K R ++ ++ + + E P L+ E+ +L+ Sbjct: 136 EYIMSKTLGSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSAREADPALNVETEIEILK 195 Query: 67 HLETFEHPNVVRL---FDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKV-PEPGVPTETI 122 L HP ++++ FD +V E ++ DKV + T Sbjct: 196 KLN---HPCIIKIKNFFDA---------EDYYIVLELMEGG--ELFDKVVGNKRLKEATC 241 Query: 123 KDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQ---IKLADFGLARIYSFQMALTSV 179 K +Q+L + +LH + ++HRDLKP+N+L++S + IK+ DFG ++I + ++ Sbjct: 242 KLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTL 301 Query: 180 VVTLWYRAPEVLLQ---SSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIG 236 T Y APEVL+ + Y VD WS+G I + + G Sbjct: 302 CGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVIL---------------------FICLSG 340 Query: 237 LPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALS 296 P + V+L Q S I + ++ E DL+ K L +P R + AL Sbjct: 341 YPPFSEHRTQVSLKDQ-ITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALR 399 Query: 297 HPYFQD 302 HP+ QD Sbjct: 400 HPWLQD 405 >4EQM-A nrPDB Length = 294 Score = 82.4 bits (202), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 64/221 (28%), Positives = 112/221 (50%), Gaps = 17/221 (7%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTI-REVAVLRHL 68 +++Y+ V ++G G V+ A D + VA+K + + E+ L REV + Sbjct: 10 NERYKIVDKLGGGGMSTVYLAEDTILNIK-VAIKAIFIPPREKEETLKRFEREV---HNS 65 Query: 69 ETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMF 127 H N+V + DV + + LV E+++ L+ Y++ + +T + Sbjct: 66 SQLSHQNIVSMIDV-----DEEDDCYYLVMEYIEGPTLSEYIES--HGPLSVDTAINFTN 118 Query: 128 QLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTS---VVVTLW 184 Q+L G+ H R+VHRD+KPQNIL+ S+ +K+ DFG+A+ S + +LT V+ T+ Sbjct: 119 QILDGIKHAHDMRIVHRDIKPQNILIDSNKTLKIFDFGIAKALS-ETSLTQTNHVLGTVQ 177 Query: 185 YRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDV 225 Y +PE + D++S+G + EM +P F G + V Sbjct: 178 YFSPEQAKGEATDECTDIYSIGIVLYEMLVGEPPFNGETAV 218 >6C9D-A nrPDB Length = 459 Score = 82.4 bits (202), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 61/201 (30%), Positives = 97/201 (48%), Gaps = 15/201 (7%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRV-RVQTGEEGMPLSTIREVAVLRHLET 70 Y IG+G + KV AR + G R VA+K + + Q P S + +R ++ Sbjct: 22 NYRLQKTIGKGNFAKVKLARHVLTG-REVAVKIIDKTQLN----PTSLQKLFREVRIMKI 76 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQL 129 HPN+V+LF+V +T L LV E+ ++ YL V + + + Q+ Sbjct: 77 LNHPNIVKLFEVIETEKT-----LYLVMEYASGGEVFDYL--VAHGRMKEKEARAKFRQI 129 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPE 189 + + + H +VHRDLK +N+L+ IK+ADFG + ++ L + Y APE Sbjct: 130 VSAVQYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDEFCGSPPYAAPE 189 Query: 190 VLLQSSYATP-VDLWSVGCIF 209 + Y P VD+WS+G I Sbjct: 190 LFQGKKYDGPEVDVWSLGVIL 210 >2HAK-A nrPDB Length = 328 Score = 82.0 bits (201), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 63/215 (29%), Positives = 102/215 (47%), Gaps = 15/215 (6%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRV-RVQTGEEGMPLSTIREVAVLRHLET 70 Y IG+G + KV AR + G R VA+K + + Q P S + +R ++ Sbjct: 16 NYRLQKTIGKGNFAKVKLARHVLTG-REVAVKIIDKTQLN----PTSLQKLFREVRIMKI 70 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQL 129 HPN+V+LF+V +T L LV E+ ++ YL V + + + Q+ Sbjct: 71 LNHPNIVKLFEVIETEKT-----LYLVMEYASGGEVFDYL--VAHGRMKEKEARAKFRQI 123 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPE 189 + + + H +VHRDLK +N+L+ IK+ADFG + ++ L + + Y APE Sbjct: 124 VSAVQYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPE 183 Query: 190 VLLQSSYATP-VDLWSVGCIFAEMFRRKPLFRGSS 223 + Y P VD+WS+G I + F G + Sbjct: 184 LFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQN 218 >4TNB-A nrPDB Length = 590 Score = 82.0 bits (201), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 60/206 (29%), Positives = 92/206 (44%), Gaps = 7/206 (3%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVR 78 +G+G +G+V A ++ G+ A KR+ E+ E L + E N Sbjct: 192 LGKGGFGEVC-ACQVRATGKMYACKRL-----EKKRIKKRKGESMALNEKQILEKVNSQF 245 Query: 79 LFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHS 138 + ++ T L L + DL ++ + PG E ++L GL+ LH Sbjct: 246 VVNLAYAYETKDALCLVLTIMN-GGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHH 304 Query: 139 HRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYAT 198 V+RDLKP+NIL+ G I+++D GLA + V T+ Y APEVL Y Sbjct: 305 ENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGL 364 Query: 199 PVDLWSVGCIFAEMFRRKPLFRGSSD 224 D W +GC+ EM + FRG + Sbjct: 365 SPDYWGLGCLIYEMIEGQSPFRGRKE 390 >2YCR-A nrPDB Length = 323 Score = 81.6 bits (200), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 77/299 (25%), Positives = 132/299 (44%), Gaps = 51/299 (17%) Query: 19 IGEGAYGKV---FKARDLKNGG-RFVALKRVRVQTGEEGMP-LSTIREVAVLRHLETFEH 73 +G GA G+V F+ + K + ++ ++ + + E P L+ E+ +L+ L H Sbjct: 18 LGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLN---H 74 Query: 74 PNVVRL---FDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKV-PEPGVPTETIKDMMFQL 129 P ++++ FD +V E ++ DKV + T K +Q+ Sbjct: 75 PCIIKIKNFFDA---------EDYYIVLELMEGG--ELFDKVVGNKRLKEATCKLYFYQM 123 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQ---IKLADFGLARIYSFQMALTSVVVTLWYR 186 L + +LH + ++HRDLKP+N+L++S + IK+ DFG ++I + ++ T Y Sbjct: 124 LLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYL 183 Query: 187 APEVLLQ---SSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDW 243 APEVL+ + Y VD WS+G I + + G P + Sbjct: 184 APEVLVSVGTAGYNRAVDCWSLGVIL---------------------FICLSGYPPFSEH 222 Query: 244 PRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQD 302 V+L Q S I + ++ E DL+ K L +P R + AL HP+ QD Sbjct: 223 RTQVSLKDQ-ITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQD 280 >6CCF-A nrPDB Length = 290 Score = 81.6 bits (200), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 91/324 (28%), Positives = 142/324 (43%), Gaps = 76/324 (23%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRV-----------------RVQTGEEG 53 QY+ +EIG+GAYG V A + ++ R A+K + R +G Sbjct: 5 NQYKLQSEIGKGAYGVVRLAYN-ESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQG 63 Query: 54 MPLSTI-------REVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLT 106 P + +E+A+L+ L+ H NVV+L +V E L LVF+ Sbjct: 64 GPAKQLLPLERVYQEIAILKKLD---HVNVVKLIEVLD---DPAEDNLYLVFD------- 110 Query: 107 TYLDKVPEPGVPT------ETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIK 160 L K P VP E + + ++ GL++LH ++VHRD+KP N+L+ G +K Sbjct: 111 -LLRKGPVMEVPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVK 169 Query: 161 LADFGLARIYSFQMA-LTSVVVTLWYRAPEVLL---QSSYATPVDLWSVGC-IFAEMFRR 215 +ADFG++ + A L+S T + APE + QS +D+W+ G ++ ++ + Sbjct: 170 IADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGK 229 Query: 216 KPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKD 275 P I D I +AL R+ + P E +I E KD Sbjct: 230 CPF------------IDDFI-----------LALHRKIKNEPVVFPEE---PEISEELKD 263 Query: 276 LLLKCLTFNPAKRISAYSALSHPY 299 L+LK L NP RI HP+ Sbjct: 264 LILKMLDKNPETRIGVPDIKLHPW 287 >4GS6-A nrPDB Length = 315 Score = 81.3 bits (199), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 76/280 (27%), Positives = 128/280 (45%), Gaps = 53/280 (18%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVR 78 +G GA+G V KA K + VA+K++ ++ + + LR L HPN+V+ Sbjct: 17 VGRGAFGVVCKA---KWRAKDVAIKQIESESERKAF-------IVELRQLSRVNHPNIVK 66 Query: 79 LFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMM---FQLLRGLDF 135 L+ C + LV E+ + + EP +P T M Q +G+ + Sbjct: 67 LYGACL-------NPVCLVMEYAEGGSLYNVLHGAEP-LPYYTAAHAMSWCLQCSQGVAY 118 Query: 136 LHSHR---VVHRDLKPQNILVTSSGQI-KLADFGLARIYSFQMALTSVVVTLWYRAPEVL 191 LHS + ++HRDLKP N+L+ + G + K+ DFG A Q +T+ + + APEV Sbjct: 119 LHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTA--CDIQTHMTNNKGSAAWMAPEVF 176 Query: 192 LQSSYATPVDLWSVGCIFAEMF-RRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALP 250 S+Y+ D++S G I E+ RRKP D IG P Sbjct: 177 EGSNYSEKCDVFSWGIILWEVITRRKP--------------FDEIGGPAFRI-------- 214 Query: 251 RQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRIS 290 A H+ + P+ + ++ + + L+ +C + +P++R S Sbjct: 215 MWAVHNGTRPPL---IKNLPKPIESLMTRCWSKDPSQRPS 251 >4C0T-A nrPDB Length = 974 Score = 81.3 bits (199), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 75/308 (24%), Positives = 128/308 (41%), Gaps = 67/308 (21%) Query: 18 EIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVV 77 E+GEG+Y V A D G ++ V+V + ++ V + +H + Sbjct: 273 ELGEGSYSTVILATDKITGKQYA----VKVLDKRHIIKEKKVKYVNIEKHA-------LN 321 Query: 78 RLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPG-----------VPTETIKDMM 126 RL ++R ++L F D+D ++ G + E + Sbjct: 322 RL--------SNRLGVISLYFTFQDKDSLYFVLDYASNGELLTLIKRYNTLNEECTRHFG 373 Query: 127 FQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARI----------YSFQMAL 176 Q+L + ++H + V+HRDLKP+NIL+ +I++ DFG AR+ Y + Sbjct: 374 AQILDAIKYMHDNGVIHRDLKPENILLDDKMRIQITDFGTARLLEKKNDESEEYPVDVRA 433 Query: 177 TSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIG 236 S V T Y +PE+L P D+W+ GCI +M KP F+ +++ KI + Sbjct: 434 KSFVGTAEYVSPELLENKYCGKPGDVWAFGCIIYQMIAGKPPFKATNEYLTFQKITKL-- 491 Query: 237 LPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALS 296 + AF + F T I +DL+ K L P++R + Sbjct: 492 --------------QFAFSA-------GFPTII----RDLIKKILVLQPSRRATIPEIQK 526 Query: 297 HPYFQDLE 304 H +FQ ++ Sbjct: 527 HYFFQSVD 534 >2BUJ-A nrPDB Length = 317 Score = 80.9 bits (198), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 67/227 (29%), Positives = 104/227 (45%), Gaps = 28/227 (12%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRV---QTGEEGMPLSTIREVAVLR 66 ++ Y + ++GEG + V L +G F ALKR+ Q EE RE + R Sbjct: 28 NKHYLFIQKLGEGGFSYVDLVEGLHDG-HFYALKRILCHEQQDREEAQ-----READMHR 81 Query: 67 HLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPG--VPTETIKD 124 F HPN++RL C R + L+ L ++++ + G + + I Sbjct: 82 ---LFNHPNILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFLTEDQILW 138 Query: 125 MMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFG-----LARIYSFQMALT-- 177 ++ + RGL+ +H+ HRDLKP NIL+ GQ L D G + + ALT Sbjct: 139 LLLGICRGLEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSRQALTLQ 198 Query: 178 ---SVVVTLWYRAPEVLLQSSYAT---PVDLWSVGCI-FAEMFRRKP 217 + T+ YRAPE+ S+ D+WS+GC+ +A MF P Sbjct: 199 DWAAQRCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGP 245 >3ZZW-A nrPDB Length = 289 Score = 80.9 bits (198), Expect = 8e-16, Method: Compositional matrix adjust. Identities = 67/249 (26%), Positives = 119/249 (47%), Gaps = 30/249 (12%) Query: 18 EIGEGAYGKVFKARDL--KNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPN 75 E+GE +GKV+K G + A+ ++ EG R A+LR +HPN Sbjct: 16 ELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLR--ARLQHPN 73 Query: 76 VVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYL--------------DKVPEPGVPTE 120 VV L V T ++ L+++F + DL +L D+ + + Sbjct: 74 VVCLLGVVT-----KDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPP 128 Query: 121 TIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLAR-IYS--FQMALT 177 ++ Q+ G+++L SH VVH+DL +N+LV +K++D GL R +Y+ + L Sbjct: 129 DFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLG 188 Query: 178 SVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRR--KPLFRGSSDVDQLGKILDVI 235 + ++ + + APE ++ ++ D+WS G + E+F +P + G S+ D + I + Sbjct: 189 NSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQP-YCGYSNQDVVEMIRNRQ 247 Query: 236 GLPGEEDWP 244 LP +D P Sbjct: 248 VLPCPDDCP 256 >3UDB-A nrPDB Length = 317 Score = 80.5 bits (197), Expect = 9e-16, Method: Compositional matrix adjust. Identities = 64/206 (31%), Positives = 96/206 (46%), Gaps = 18/206 (8%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETF 71 +YE V +IG G +G RD K VA+K + E G + + ++ H + Sbjct: 20 RYELVKDIGAGNFGVARLMRD-KQANELVAVKYI-----ERGEKIDENVKREIINH-RSL 72 Query: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQ-LL 130 HPN+VR +V T L +V E+ +++ G +E FQ L+ Sbjct: 73 RHPNIVRFKEVILTP-----THLAIVMEYASG--GELFERICNAGRFSEDEARFFFQQLI 125 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTSS--GQIKLADFGLARIYSFQMALTSVVVTLWYRAP 188 G+ + H+ +V HRDLK +N L+ S ++K+ADFG ++ S V T Y AP Sbjct: 126 SGVSYAHAMQVAHRDLKLENTLLDGSPAPRLKIADFGYSKASVLHSQPKSAVGTPAYIAP 185 Query: 189 EVLLQSSYATPV-DLWSVGCIFAEMF 213 EVLL+ Y V D+WS G M Sbjct: 186 EVLLKKEYDGKVADVWSCGVTLYVML 211 >3F3Z-A nrPDB Length = 277 Score = 80.5 bits (197), Expect = 9e-16, Method: Compositional matrix adjust. Identities = 71/300 (23%), Positives = 128/300 (42%), Gaps = 49/300 (16%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRH-- 67 +Q Y IG G++G+V + K R++ + +P + +V + Sbjct: 8 NQYYTLENTIGRGSWGEV----------KIAVQKGTRIRRAAKKIPKYFVEDVDRFKQEI 57 Query: 68 --LETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTET-IKD 124 +++ +HPN++RL++ + T + LV E ++V V E+ Sbjct: 58 EIMKSLDHPNIIRLYETF-----EDNTDIYLVMELCTGG--ELFERVVHKRVFRESDAAR 110 Query: 125 MMFQLLRGLDFLHSHRVVHRDLKPQNILV---TSSGQIKLADFGLARIYSFQMALTSVVV 181 +M +L + + H V HRDLKP+N L + +KL DFGLA + + + V Sbjct: 111 IMKDVLSAVAYCHKLNVAHRDLKPENFLFLTDSPDSPLKLIDFGLAARFKPGKMMRTKVG 170 Query: 182 TLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEE 241 T +Y +P+V L+ Y D WS G + + P F +D + + KI + E+ Sbjct: 171 TPYYVSPQV-LEGLYGPECDEWSAGVMMYVLLCGYPPFSAPTDSEVMLKIREGTFTFPEK 229 Query: 242 DWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQ 301 DW ++ + L+ + LT +P +RI++ AL H +F+ Sbjct: 230 DW-----------------------LNVSPQAESLIRRLLTKSPKQRITSLQALEHEWFE 266 >1FOT-A nrPDB Length = 318 Score = 80.5 bits (197), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 62/239 (25%), Positives = 112/239 (46%), Gaps = 41/239 (17%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQ----------TGEEGMPLSTIR 60 Q ++ + +G G++G+V R NG R+ A+K ++ + T +E + LS + Sbjct: 6 QDFQILRTLGTGSFGRVHLIRSRHNG-RYYAMKVLKKEIVVRLKQVEHTNDERLMLSIV- 63 Query: 61 EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPT 119 HP ++R++ ++ ++ ++ ++++ +L + L K P Sbjct: 64 -----------THPFIIRMWGTFQDAQ-----QIFMIMDYIEGGELFSLLRKSQR--FPN 105 Query: 120 ETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSV 179 K ++ L++LHS +++RDLKP+NIL+ +G IK+ DFG A+ + V Sbjct: 106 PVAKFYAAEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKY------VPDV 159 Query: 180 VVTLW----YRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDV 234 TL Y APEV+ Y +D WS G + EM F S+ + KIL+ Sbjct: 160 TYTLCGTPDYIAPEVVSTKPYNKSIDWWSFGILIYEMLAGYTPFYDSNTMKTYEKILNA 218 >4U41-A nrPDB Length = 332 Score = 80.1 bits (196), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 64/213 (30%), Positives = 99/213 (46%), Gaps = 14/213 (6%) Query: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 +E V +G G YG+V+K R +K G L ++V E E+ +L+ Sbjct: 26 FELVEVVGNGTYGQVYKGRHVKTG----QLAAIKVMDVTEDEEEEIKLEINMLKKYS--H 79 Query: 73 HPNVVRLFDV-CTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTET-IKDMMFQLL 130 H N+ + S + +L LV E T L K + E I + ++L Sbjct: 80 HRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREIL 139 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGL-ARIYSFQMALTSVVVTLWYRAPE 189 RGL LH H V+HRD+K QN+L+T + ++KL DFG+ A++ + + T ++ APE Sbjct: 140 RGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 199 Query: 190 VLL-----QSSYATPVDLWSVGCIFAEMFRRKP 217 V+ ++Y DLWS G EM P Sbjct: 200 VIACDENPDATYDYRSDLWSCGITAIEMAEGAP 232 >5AMN-A nrPDB Length = 299 Score = 79.7 bits (195), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 63/208 (30%), Positives = 106/208 (50%), Gaps = 21/208 (10%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREV-AVLRHLETFEHPNVV 77 +GEG +GKV KA GR V V+ +E S +R++ + L+ HP+V+ Sbjct: 31 LGEGEFGKVVKATAFHLKGR-AGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVI 89 Query: 78 RLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPE--PGVPTE---TIKDMM---FQ 128 +L+ C+ ++ L L+ E+ L +L + + PG P E T+ D++ +Q Sbjct: 90 KLYGACS-----QDGPLLLIVEYAKYGSLRGFLRESRKVGPGYPDERALTMGDLISFAWQ 144 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLAR-IY---SFQMALTSVVVTLW 184 + +G+ +L ++VHRDL +NILV ++K++DFGL+R +Y S+ + W Sbjct: 145 ISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKW 204 Query: 185 YRAPEVLLQSSYATPVDLWSVGCIFAEM 212 A E L Y T D+WS G + E+ Sbjct: 205 M-AIESLFDHIYTTQSDVWSFGVLLWEI 231 >3PVW-A nrPDB Length = 695 Score = 79.7 bits (195), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 66/218 (30%), Positives = 109/218 (50%), Gaps = 24/218 (11%) Query: 19 IGEGAYGKVFKARDLKNGGRFVAL----KRVRVQTGEEGMPLSTIREVAVLRHLETFEHP 74 IG G +G+V+ R G + KR++++ GE + E +L + T + P Sbjct: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGE----TLALNERIMLSLVSTGDCP 252 Query: 75 NVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMF---QLL 130 F VC KL+ + + ++ DL +L + GV +E DM F +++ Sbjct: 253 -----FIVCMSYAFHTPDKLSFILDLMNGGDLHYHLS---QHGVFSEA--DMRFYAAEII 302 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEV 190 GL+ +H+ VV+RDLKP NIL+ G ++++D GLA +S + S V T Y APEV Sbjct: 303 LGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHAS-VGTHGYMAPEV 361 Query: 191 LLQS-SYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQ 227 L + +Y + D +S+GC+ ++ R FR D+ Sbjct: 362 LQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK 399 >5UUU-A nrPDB Length = 547 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 66/218 (30%), Positives = 109/218 (50%), Gaps = 24/218 (11%) Query: 19 IGEGAYGKVFKARDLKNGGRFVAL----KRVRVQTGEEGMPLSTIREVAVLRHLETFEHP 74 IG G +G+V+ R G + KR++++ GE + E +L + T + P Sbjct: 206 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGE----TLALNERIMLSLVSTGDCP 261 Query: 75 NVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMF---QLL 130 F VC KL+ + + ++ DL +L + GV +E DM F +++ Sbjct: 262 -----FIVCMSYAFHTPDKLSFILDLMNGGDLHYHLS---QHGVFSEA--DMRFYAAEII 311 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEV 190 GL+ +H+ VV+RDLKP NIL+ G ++++D GLA +S + S V T Y APEV Sbjct: 312 LGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHAS-VGTHGYMAPEV 370 Query: 191 LLQS-SYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQ 227 L + +Y + D +S+GC+ ++ R FR D+ Sbjct: 371 LQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK 408 >3TXO-A nrPDB Length = 353 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 80/317 (25%), Positives = 137/317 (43%), Gaps = 52/317 (16%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVR----VQTGEEGMPLSTIREVAVLRH 67 +E + +G+G++GKV AR +K G A+K ++ +Q + ++ R +++ R+ Sbjct: 24 NFEFIRVLGKGSFGKVMLAR-VKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARN 82 Query: 68 LETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMM 126 HP + +LF C DR L V E V+ DL ++ K + Sbjct: 83 -----HPFLTQLF--CCFQTPDR---LFFVMEFVNGGDLMFHIQKSRR--FDEARARFYA 130 Query: 127 FQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVV-TLWY 185 +++ L FLH +++RDLK N+L+ G KLADFG+ + T+ T Y Sbjct: 131 AEIISALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDY 190 Query: 186 RAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPR 245 APE+L + Y VD W++G + EM F ++ D IL+ Sbjct: 191 IAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILN-----------D 239 Query: 246 DVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISA------YSALSHPY 299 +V P T + E +L +T NP R+ + ++ L HP+ Sbjct: 240 EVVYP----------------TWLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPF 283 Query: 300 FQDLERCKENLDSHLPP 316 F++++ + N PP Sbjct: 284 FKEIDWAQLNHRQIEPP 300 >5LOH-A nrPDB Length = 341 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 80/321 (24%), Positives = 136/321 (42%), Gaps = 60/321 (18%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRH-LE 69 +++ V I GA+GKV+ + GG+ A+K V+ + + + +V R L Sbjct: 36 EEFSIVKPISRGAFGKVYLGQ---KGGKLYAVKVVK---KADMINKNMTHQVQAERDALA 89 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEH-VDQDLTT------YLDKVPEPGVPTETI 122 + P +V L+ + LV E+ + D+ + Y D+ E Sbjct: 90 LSKSPFIVHLY-----YSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDE--------EMA 136 Query: 123 KDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARI-YSFQMALTSVVV 181 + ++ LD+LH H ++HRDLKP N+L+++ G IKL DFGL+++ + + + ++ Sbjct: 137 VKYISEVALALDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILT 196 Query: 182 TLW------YRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVI 235 T Y APE+LL ++ VD W++G E P F + IL Sbjct: 197 TRTFCGTPDYLAPELLLGRAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILK-- 254 Query: 236 GLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSAL 295 RD+ P E+ ++D + ++L LT + KR Sbjct: 255 ---------RDIPWPEG----------EEKLSDNAQSAVEIL---LTIDDTKRAGMKELK 292 Query: 296 SHPYFQDLERCKENLDSHLPP 316 HP F D++ ENL P Sbjct: 293 RHPLFSDVDW--ENLQHQTMP 311 >3IS5-A nrPDB Length = 285 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 77/295 (26%), Positives = 127/295 (43%), Gaps = 51/295 (17%) Query: 18 EIGEGAYGKVFKARDLKNGGRFVALKRV--RVQTGEEGMPLSTIR-EVAVLRHLETFEHP 74 ++G GA+G V + +G L+RV + +P+ I E+ VL+ L+ HP Sbjct: 29 KLGSGAFGDVHLVEERSSG-----LERVIKTINKDRSQVPMEQIEAEIEVLKSLD---HP 80 Query: 75 NVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPG--VPTETIKDMMFQLLR 131 N++++F+V + + +V E + +L + G + + ++M Q++ Sbjct: 81 NIIKIFEVF-----EDYHNMYIVMETCEGGELLERIVSAQARGKALSEGYVAELMKQMMN 135 Query: 132 GLDFLHSHRVVHRDLKPQNILVTSS---GQIKLADFGLARIYSFQMALTSVVVTLWYRAP 188 L + HS VVH+DLKP+NIL + IK+ DFGLA ++ T+ T Y AP Sbjct: 136 ALAYFHSQHVVHKDLKPENILFQDTSPHSPIKIIDFGLAELFKSDEHSTNAAGTALYMAP 195 Query: 189 EVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSS--DVDQLGKILDVIGLPGEEDWPRD 246 EV + D+WS G + + F G+S +V Q + Sbjct: 196 EV-FKRDVTFKCDIWSAGVVMYFLLTGCLPFTGTSLEEVQQKATYKE------------- 241 Query: 247 VALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQ 301 P A + P DLL + LT +P +R SA L H +F+ Sbjct: 242 ---PNYAVECRPLTP----------QAVDLLKQMLTKDPERRPSAAQVLHHEWFK 283 >3CJF-A nrPDB Length = 309 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 66/213 (30%), Positives = 102/213 (47%), Gaps = 25/213 (11%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR----EVAVLRHLETFEHP 74 +G GA+G+V +A D + + V V+ +EG S R E+ +L H+ H Sbjct: 35 LGRGAFGQVIEA-DAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIG--HHL 91 Query: 75 NVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPGVPTETI-KDMM------ 126 NVV L CT L ++ E +L+TYL VP + + KD + Sbjct: 92 NVVNLLGACTKP----GGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKDLYKDFLTLEHLI 147 Query: 127 ---FQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLAR-IYS--FQMALTSVV 180 FQ+ +G++FL S + +HRDL +NIL++ +K+ DFGLAR IY + Sbjct: 148 CYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDAR 207 Query: 181 VTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMF 213 + L + APE + Y D+WS G + E+F Sbjct: 208 LPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIF 240 >3QA8-A nrPDB Length = 676 Score = 79.0 bits (193), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 68/231 (29%), Positives = 105/231 (45%), Gaps = 22/231 (9%) Query: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 +E +G G +G V + ++ G VA+K+ R +E P + R ++ ++ Sbjct: 16 WEMKERLGTGGFGYVLRWIH-QDTGEQVAIKQCR----QELSPKNRERWCLEIQIMKKLN 70 Query: 73 HPNVVRLFDVCTVSRTDRETKLT------LVFEHVDQ-DLTTYLDKVPEP-GVPTETIKD 124 HPNVV +V D KL L E+ + DL YL++ G+ I+ Sbjct: 71 HPNVVSAREV-----PDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGPIRT 125 Query: 125 MMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQI---KLADFGLARIYSFQMALTSVVV 181 ++ + L +LH +R++HRDLKP+NI++ Q K+ D G A+ T V Sbjct: 126 LLSDISSALRYLHENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQGELCTEFVG 185 Query: 182 TLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRR-KPLFRGSSDVDQLGKI 231 TL Y APE+L Q Y VD WS G + E +P V GK+ Sbjct: 186 TLQYLAPELLEQKKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHGKV 236 >4YHJ-A nrPDB Length = 584 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 56/205 (27%), Positives = 89/205 (43%), Gaps = 28/205 (13%) Query: 104 DLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLAD 163 DL ++ + PG + +L GL+ L R+V+RDLKP+NIL+ G I+++D Sbjct: 271 DLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISD 330 Query: 164 FGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSS 223 GLA + V T+ Y APEV+ Y D W +GC+ EM + F+ Sbjct: 331 LGLATEIPEGQRVRGRVGTVGYMAPEVVNNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYK 390 Query: 224 DVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTF 283 + + ++ Q + + + EKF D + + LL K Sbjct: 391 EKVKWEEV-------------------DQRIKNDTEEYSEKFSEDAKSICRMLLTK---- 427 Query: 284 NPAKRI-----SAYSALSHPYFQDL 303 NP+KR+ A HP F+D+ Sbjct: 428 NPSKRLGCRGEGAAGVKQHPVFKDI 452 >5DYK-A nrPDB Length = 853 Score = 78.6 bits (192), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 66/238 (27%), Positives = 111/238 (46%), Gaps = 39/238 (16%) Query: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMF-QLL 130 +HP ++RL RT +++K + Y D + + G+ +++ ++ Sbjct: 597 DHPFIIRLV------RTFKDSKYFYFLTELVTGGELY-DAIRKLGLLSKSQAQFYLGSII 649 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEV 190 +++LH +V+RDLKP+NIL+ G +KL DFG A+ Q ++V T Y APEV Sbjct: 650 LAIEYLHERNIVYRDLKPENILLDKQGYVKLIDFGCAK--KVQGRAYTLVGTPHYMAPEV 707 Query: 191 LLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALP 250 +L Y VD+W++G E F PL G+ + DQL D+ L G+ +P Sbjct: 708 ILGKGYGCTVDIWALGICLYE-FICGPLPFGNDEEDQLEIFRDI--LTGQLTFP------ 758 Query: 251 RQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKR----ISAYSALS-HPYFQDL 303 +VTD D + +L+ + L P R I+ + + HP+F + Sbjct: 759 -------------DYVTDTDSI--NLMKRLLCRLPQGRIGCSINGFKDIKDHPFFSNF 801 >4K33-A nrPDB Length = 325 Score = 78.6 bits (192), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 61/219 (27%), Positives = 109/219 (49%), Gaps = 32/219 (14%) Query: 19 IGEGAYGKVFKA------RDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 +GEGA+G+V A +D VA+K ++ ++ + + E+ +++ + + Sbjct: 44 LGEGAFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLS-DLVSEMEMMKMIG--K 100 Query: 73 HPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGV---------PTE-- 120 H N++ L CT + L ++ E+ + +L +L PG+ P E Sbjct: 101 HKNIINLLGACT-----QGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTSKPPEEQL 155 Query: 121 TIKDMM---FQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLAR---IYSFQM 174 T KD++ +Q+ RG+++L S + +HRDL +N+LVT +K+ADFGLAR + Sbjct: 156 TFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYK 215 Query: 175 ALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMF 213 T+ + + + APE L Y D+WS G + E+F Sbjct: 216 ETTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIF 254 >5O0Y-A nrPDB Length = 579 Score = 78.2 bits (191), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 83/305 (27%), Positives = 133/305 (43%), Gaps = 64/305 (20%) Query: 24 YGKVFKARDLKNGGRFVALKRVRVQTG-----EEGMPLSTIREVAVLRHLETFEHPNVVR 78 + +V+KA DL R+VA+K ++ +E RE + + L+ HP +V+ Sbjct: 297 FSEVYKAFDL-TEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELD---HPRIVK 352 Query: 79 LFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLH 137 L+D ++ TD V E+ + DL YL + + + + ++ Q++ L +L+ Sbjct: 353 LYDYFSLD-TD---SFCTVLEYCEGNDLDFYLKQ--HKLMSEKEARSIIMQIVNALKYLN 406 Query: 138 SHR--VVHRDLKPQNILV---TSSGQIKLADFGLARIY---SFQ----MALTSV-VVTLW 184 + ++H DLKP NIL+ T+ G+IK+ DFGL++I S+ M LTS T W Sbjct: 407 EIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYW 466 Query: 185 YRAPEVLLQS----SYATPVDLWSVGCIFAE-MFRRKPLFRGSS--DVDQLGKILDV--I 235 Y PE + + VD+WSVG IF + ++ RKP S D+ Q IL + Sbjct: 467 YLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEV 526 Query: 236 GLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSAL 295 P P+ V P K + +CL + RI Sbjct: 527 QFP-----PKPVVTPE---------------------AKAFIRRCLAYRKEDRIDVQQLA 560 Query: 296 SHPYF 300 PY Sbjct: 561 CDPYL 565 >3A8W-A nrPDB Length = 345 Score = 78.2 bits (191), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 66/220 (30%), Positives = 105/220 (47%), Gaps = 17/220 (7%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHL-- 68 Q ++ + IG G+Y KV R LK R A+K V+ + + I V +H+ Sbjct: 9 QDFDLLRVIGRGSYAKVLLVR-LKKTDRIYAMKVVKKELVNDD---EDIDWVQTEKHVFE 64 Query: 69 ETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMF 127 + HP +V L E++L V E+V+ DL ++ + + +P E + Sbjct: 65 QASNHPFLVGLHSCFQT-----ESRLFFVIEYVNGGDLMFHMQR--QRKLPEEHARFYSA 117 Query: 128 QLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVV-TLWYR 186 ++ L++LH +++RDLK N+L+ S G IKL D+G+ + TS T Y Sbjct: 118 EISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYI 177 Query: 187 APEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFR--GSSD 224 APE+L Y VD W++G + EM + F GSSD Sbjct: 178 APEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSD 217 >3KN6-A nrPDB Length = 325 Score = 77.8 bits (190), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 75/296 (25%), Positives = 131/296 (44%), Gaps = 36/296 (12%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVR 78 +GEG++ K K+ F V+ + M +T +E+ L+ E HPN+V+ Sbjct: 19 LGEGSFSICRKCVHKKSNQAFA------VKIISKRMEANTQKEITALKLCEG--HPNIVK 70 Query: 79 LFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKD-MMFQLLRGLDFLH 137 L +V + LV E ++ +++ + +ET +M +L+ + +H Sbjct: 71 LHEV-----FHDQLHTFLVMELLNGG--ELFERIKKKKHFSETEASYIMRKLVSAVSHMH 123 Query: 138 SHRVVHRDLKPQNILVTSSG---QIKLADFGLARIYS-FQMALTSVVVTLWYRAPEVLLQ 193 VVHRDLKP+N+L T +IK+ DFG AR+ L + TL Y APE+L Q Sbjct: 124 DVGVVHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQ 183 Query: 194 SSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQA 253 + Y DLWS+G I M + F+ ++++ + D+ + Sbjct: 184 NGYDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDF---------S 234 Query: 254 FHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKEN 309 F ++ + ++ + KDL+ LT +P KR+ + + QD + N Sbjct: 235 FEGEAWK-------NVSQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQLSSN 283 >1FVR-A nrPDB Length = 327 Score = 77.8 bits (190), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 65/210 (30%), Positives = 97/210 (46%), Gaps = 24/210 (11%) Query: 19 IGEGAYGKVFKARDLKNGGRF-VALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVV 77 IGEG +G+V KAR K+G R A+KR++ ++ E+ VL L HPN++ Sbjct: 33 IGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHR-DFAGELEVLCKLG--HHPNII 89 Query: 78 RLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKV------PEPGVPTETIKDMMFQLL 130 L C + L L E+ +L +L K P + T + Q L Sbjct: 90 NLLGAC-----EHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQL 144 Query: 131 --------RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVT 182 RG+D+L + +HRDL +NILV + K+ADFGL+R + T + Sbjct: 145 LHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLP 204 Query: 183 LWYRAPEVLLQSSYATPVDLWSVGCIFAEM 212 + + A E L S Y T D+WS G + E+ Sbjct: 205 VRWMAIESLNYSVYTTNSDVWSYGVLLWEI 234 >2HW6-A nrPDB Length = 307 Score = 77.8 bits (190), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 82/306 (26%), Positives = 124/306 (40%), Gaps = 49/306 (16%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVR 78 +GEGAY KV A L+NG + A+K + Q G REV L + + N++ Sbjct: 21 LGEGAYAKVQGAVSLQNGKEY-AVKIIEKQAGHSRS--RVFREVETLYQCQG--NKNILE 75 Query: 79 LFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLH 137 L + + +T+ LVFE + + ++ K + ++ + LDFLH Sbjct: 76 LIEF-----FEDDTRFYLVFEKLQGGSILAHIQK--QKHFNEREASRVVRDVAAALDFLH 128 Query: 138 SHRVVHRDLKPQNILVTSSGQ---IKLADFGLARIYSFQMALTSVVV--------TLWYR 186 + + HRDLKP+NIL S + +K+ DF L + T + + Y Sbjct: 129 TKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYM 188 Query: 187 APEVL-----LQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVD---QLGKILDVIGLP 238 APEV+ + Y DLWS+G + M P F G D G++ V Sbjct: 189 APEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVC--- 245 Query: 239 GEEDWPRDVALPRQAFHSKSAQPIE---KFVTDIDELGKDLLLKCLTFNPAKRISAYSAL 295 + F S E K I KDL+ K L + +R+SA L Sbjct: 246 -----------QNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVL 294 Query: 296 SHPYFQ 301 HP+ Q Sbjct: 295 QHPWVQ 300 >4XCU-A nrPDB Length = 300 Score = 77.8 bits (190), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 58/211 (27%), Positives = 100/211 (47%), Gaps = 25/211 (11%) Query: 19 IGEGAYGKVFKARDL------KNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 +GEG +G+V +A + VA+K ++ ++ + + E+ V++ + Sbjct: 25 LGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDL-ADLVSEMEVMKLIG--R 81 Query: 73 HPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPG-----VPTETIKDMM 126 H N++ L VCT +E L ++ E + +L +L PG + + Sbjct: 82 HKNIINLLGVCT-----QEGPLYVIVECAAKGNLREFLRARRPPGSSEGPLSFPVLVSCA 136 Query: 127 FQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLAR----IYSFQMALTSVVVT 182 +Q+ RG+ +L S + +HRDL +N+LVT +K+ADFGLAR I ++ + Sbjct: 137 YQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPV 196 Query: 183 LWYRAPEVLLQSSYATPVDLWSVGCIFAEMF 213 W APE L Y D+WS G + E+F Sbjct: 197 KWM-APEALFDRVYTHQSDVWSFGILLWEIF 226 >5X02-A nrPDB Length = 347 Score = 77.4 bits (189), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 64/226 (28%), Positives = 104/226 (46%), Gaps = 41/226 (18%) Query: 19 IGEGAYGKVFKARDL---KNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPN 75 +G GA+GKV A K G ++ + + + + E+ ++ L + H N Sbjct: 56 LGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGS--HEN 113 Query: 76 VVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYL----DKVPEPGVPTE---------- 120 +V L CT+S + L+FE+ DL YL +K E + E Sbjct: 114 IVNLLGACTLS-----GPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRLEEEED 168 Query: 121 ----TIKDMM---FQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQ 173 T +D++ +Q+ +G++FL VHRDL +N+LVT +K+ DFGLAR Sbjct: 169 LNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDI--- 225 Query: 174 MALTSVVVT------LWYRAPEVLLQSSYATPVDLWSVGCIFAEMF 213 M+ ++ VV + + APE L + Y D+WS G + E+F Sbjct: 226 MSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIF 271 >4AT3-A nrPDB Length = 299 Score = 77.0 bits (188), Expect = 9e-15, Method: Compositional matrix adjust. Identities = 63/228 (27%), Positives = 111/228 (48%), Gaps = 31/228 (13%) Query: 18 EIGEGAYGKVFKARDL----KNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEH 73 E+GEGA+GKVF A + VA+K ++ + RE +L +L+ H Sbjct: 20 ELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFH--REAELLTNLQ---H 74 Query: 74 PNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDK-------VPEPGVPTETIKDM 125 ++V+ + VC L +VFE++ DL +L + E PTE + Sbjct: 75 EHIVKFYGVCV-----EGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQ 129 Query: 126 MF----QLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLAR-IYS--FQMALTS 178 M Q+ G+ +L S VHRDL +N LV + +K+ DFG++R +YS + Sbjct: 130 MLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGH 189 Query: 179 VVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFR--RKPLFRGSSD 224 ++ + + PE ++ + T D+WS+G + E+F ++P ++ S++ Sbjct: 190 TMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNN 237 >3HDN-A nrPDB Length = 373 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 72/222 (32%), Positives = 106/222 (47%), Gaps = 21/222 (9%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALK----RVRVQTGEEGMPLSTIREVAVLRHLETFEHP 74 IG+G++GKV AR K F A+K + ++ EE +S E VL L+ +HP Sbjct: 46 IGKGSFGKVLLARH-KAEEVFYAVKVLQKKAILKKKEEKHIMS---ERNVL--LKNVKHP 99 Query: 75 NVVRL-FDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQLLRG 132 +V L F T KL V ++++ +L +L + E + ++ Sbjct: 100 FLVGLHFSFQTAD------KLYFVLDYINGGELFYHLQR--ERCFLEPRARFYAAEIASA 151 Query: 133 LDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVV-TLWYRAPEVL 191 L +LHS +V+RDLKP+NIL+ S G I L DFGL + + TS T Y APEVL Sbjct: 152 LGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVL 211 Query: 192 LQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILD 233 + Y VD W +G + EM P F + + IL+ Sbjct: 212 HKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILN 253 >4XUF-A nrPDB Length = 297 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 64/226 (28%), Positives = 104/226 (46%), Gaps = 41/226 (18%) Query: 19 IGEGAYGKVFKARDL---KNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPN 75 +G GA+GKV A K G ++ + + + + E+ ++ L + H N Sbjct: 17 LGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGS--HEN 74 Query: 76 VVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYL----DKVPEPGVPTE---------- 120 +V L CT+S + L+FE+ DL YL +K E + E Sbjct: 75 IVNLLGACTLS-----GPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRLEEEED 129 Query: 121 ----TIKDMM---FQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQ 173 T +D++ +Q+ +G++FL VHRDL +N+LVT +K+ DFGLAR Sbjct: 130 LNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDI--- 186 Query: 174 MALTSVVVT------LWYRAPEVLLQSSYATPVDLWSVGCIFAEMF 213 M+ ++ VV + + APE L + Y D+WS G + E+F Sbjct: 187 MSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIF 232 >3ALO-A nrPDB Length = 327 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 77/297 (25%), Positives = 129/297 (43%), Gaps = 46/297 (15%) Query: 16 VAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPN 75 + EIG GAYG V K K G+ +A+KR+R E+ + V+R + + P Sbjct: 27 LGEIGRGAYGSVNKMVH-KPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMR---SSDCPY 82 Query: 76 VVRLFDV------CTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQL 129 +V+ + C + T +++V + LD V +P E + + Sbjct: 83 IVQFYGALFREGDCWICMELMSTSFDKFYKYV----YSVLDDV----IPEEILGKITLAT 134 Query: 130 LRGLDFLHSH-RVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAP 188 ++ L+ L + +++HRD+KP NIL+ SG IKL DFG++ +A T Y AP Sbjct: 135 VKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAP 194 Query: 189 EVLLQSS----YATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILDVIGLPGEEDW 243 E + S+ Y D+WS+G E+ R P + +S DQL +++ Sbjct: 195 ERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVK---------- 244 Query: 244 PRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 P Q +S+ + F+ ++ CLT + +KR L HP+ Sbjct: 245 ----GDPPQLSNSEEREFSPSFINFVN--------LCLTKDESKRPKYKELLKHPFI 289 >5FET-A nrPDB Length = 847 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 45/120 (37%), Positives = 67/120 (55%), Gaps = 5/120 (4%) Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAP 188 ++ +++LH +V+RDLKP+NIL+ G +KL DFG A+ Q ++V T Y AP Sbjct: 642 IILAIEYLHERNIVYRDLKPENILLDKQGYVKLIDFGCAK--KIQGRAYTLVGTPHYMAP 699 Query: 189 EVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA 248 EV+L Y VD+W++G E F PL G+ DQL D+ L G+ +P V+ Sbjct: 700 EVILGKGYGCTVDIWALGVCLYE-FICGPLPFGNDQEDQLEIFRDI--LTGQLTFPDYVS 756 >4LRM-A nrPDB Length = 334 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 59/223 (26%), Positives = 101/223 (45%), Gaps = 29/223 (13%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRF---VALKRVRVQTGEEGMPLSTIREVAVLR 66 + +++ + +G GA+G V+K + G + VA+K +R T + + E V+ Sbjct: 18 ETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANK-EILDEAYVMA 76 Query: 67 HLETFEHPNVVRLFDVCTVSRTDRETKLT-------LVFEHVDQDLTTYLDKVPEPGVPT 119 ++ +P+V RL +C S T+L V EH D + YL Sbjct: 77 SVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYL---------- 126 Query: 120 ETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSF---QMAL 176 + Q+ +G+++L R+VHRDL +N+LV + +K+ DFGLA++ + Sbjct: 127 ---LNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHA 183 Query: 177 TSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEM--FRRKP 217 V + + A E +L Y D+WS G E+ F KP Sbjct: 184 EGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKP 226 >4M7I-A nrPDB Length = 299 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 82/309 (26%), Positives = 133/309 (43%), Gaps = 65/309 (21%) Query: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 +E + +G G +G VF+A++ + + A+KR+R+ E +REV L LE Sbjct: 7 FEPIQCLGRGGFGVVFEAKNKVDDCNY-AIKRIRLPNRELARE-KVMREVKALAKLE--- 61 Query: 73 HPNVVRLFDVCTVSRTDRETKLT--LVFEHVDQDLTTYLDKVPEPGVPTETIKDMM---- 126 HP +VR F+ T + + + V+ ++ L E +KD M Sbjct: 62 HPGIVRYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCR-----------KENLKDWMNGRC 110 Query: 127 --------------FQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY-- 170 Q+ ++FLHS ++HRDLKP NI T +K+ DFGL Sbjct: 111 TIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQ 170 Query: 171 --SFQMALTSV---------VVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLF 219 Q LT + V T Y +PE + +SY+ VD++S+G I E+ L+ Sbjct: 171 DEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFEL-----LY 225 Query: 220 RGSSDVDQLGKILDVIGL----------PGEEDWPRDVALPRQAFHSKSAQPIEKFV-TD 268 S+ ++++ + DV L P E +D+ P ++ IE V D Sbjct: 226 PFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFED 285 Query: 269 IDELGKDLL 277 +D GK +L Sbjct: 286 LDFPGKTVL 294 >3QGY-A nrPDB Length = 286 Score = 76.6 bits (187), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 60/204 (29%), Positives = 98/204 (48%), Gaps = 23/204 (11%) Query: 16 VAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLST---IREVAVLRHLETFE 72 V EIG G +G L + G ++ +V ++T +EG +S I E V+ L Sbjct: 32 VQEIGSGQFG-------LVHLGYWLNKDKVAIKTIKEG-SMSEDDFIEEAEVMMKLS--- 80 Query: 73 HPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRG 132 HP +V+L+ VC + + LVFE ++ + + ET+ M + G Sbjct: 81 HPKLVQLYGVCL-----EQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEG 135 Query: 133 LDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLW---YRAPE 189 + +L V+HRDL +N LV + IK++DFG+ R + TS T + + +PE Sbjct: 136 MAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTR-FVLDDQYTSSTGTKFPVKWASPE 194 Query: 190 VLLQSSYATPVDLWSVGCIFAEMF 213 V S Y++ D+WS G + E+F Sbjct: 195 VFSFSRYSSKSDVWSFGVLMWEVF 218 >3DLS-A nrPDB Length = 335 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 62/231 (26%), Positives = 112/231 (48%), Gaps = 23/231 (9%) Query: 1 MEKDGL--CRAD--QQYECVAEIGEGAYGKVFKARDLKNGG----RFVALKRVRVQTGEE 52 +E +GL C + Q+Y ++ +G GA+G V+ A D + +F+ ++V E Sbjct: 10 VELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIE 69 Query: 53 GMPLSTIR-EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ--DLTTYL 109 L + E+A+L +E H N++++ D+ + + LV E DL ++ Sbjct: 70 DPKLGKVTLEIAILSRVE---HANIIKVLDI-----FENQGFFQLVMEKHGSGLDLFAFI 121 Query: 110 DKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARI 169 D+ P P + + QL+ + +L ++HRD+K +NI++ IKL DFG A Sbjct: 122 DRHPRLDEPLASY--IFRQLVSAVGYLRLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAY 179 Query: 170 YSFQMALTSVVVTLWYRAPEVLLQSSYATP-VDLWSVGC-IFAEMFRRKPL 218 + T+ Y APEVL+ + Y P +++WS+G ++ +F P Sbjct: 180 LERGKLFYTFCGTIEYCAPEVLMGNPYRGPELEMWSLGVTLYTLVFEENPF 230 >4I6B-A nrPDB Length = 308 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 54/217 (24%), Positives = 106/217 (48%), Gaps = 16/217 (7%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVA--LKRVRVQTGEEGMPLSTIREVAVLRHL 68 ++Y +G+G + K ++ DL N + A + RV + + +E+ + R Sbjct: 28 KRYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKID--KEIELHR-- 83 Query: 69 ETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTE-TIKDMMF 127 H +VV+ + D+E + ++ E+ + ++ K + V TE ++ + Sbjct: 84 -ILHHKHVVQFYHYFE----DKEN-IYILLEYCSRRSMAHILKARK--VLTEPEVRYYLR 135 Query: 128 QLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGL-ARIYSFQMALTSVVVTLWYR 186 Q++ GL +LH ++HRDLK N + S ++K+ DFGL AR+ + ++ T Y Sbjct: 136 QIVSGLKYLHEQEILHRDLKLGNFFINESMELKVGDFGLAARLEPLEHRRRTICGTPNYL 195 Query: 187 APEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSS 223 +PEVL + + D+W++GC+ M +P F ++ Sbjct: 196 SPEVLNKQGHGAESDIWALGCVMYTMLLGRPPFETTN 232 >4XLV-A nrPDB Length = 328 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 80/298 (26%), Positives = 128/298 (42%), Gaps = 72/298 (24%) Query: 18 EIGEGAYGKVFK--ARDLKNGGRFVALKRVRVQTGEEGMPLST----IREVAVLRHLETF 71 E+G+G++G V++ ARD+ G A RV V+T E L + E +V++ F Sbjct: 46 ELGQGSFGMVYEGNARDIIKGE---AETRVAVKTVNESASLRERIEFLNEASVMK---GF 99 Query: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKV-PE----PGVPTETIKDMM 126 +VVRL V VS+ + + H DL +YL + PE PG P T+++M+ Sbjct: 100 TCHHVVRLLGV--VSKGQPTLVVMELMAH--GDLKSYLRSLRPEAENNPGRPPPTLQEMI 155 Query: 127 ---FQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLAR-IYS---FQMALTSV 179 ++ G+ +L++ + VHRDL +N +V +K+ DFG+ R IY ++ + Sbjct: 156 QMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGL 215 Query: 180 VVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPG 239 + W APE L + T D+WS G + E+ Sbjct: 216 LPVRWM-APESLKDGVFTTSSDMWSFGVVLWEI--------------------------- 247 Query: 240 EEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGK---------DLLLKCLTFNPAKR 288 +L Q + S + + KFV D L + DL+ C FNP R Sbjct: 248 -------TSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPNMR 298 >5H2U-A nrPDB Length = 267 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 62/210 (29%), Positives = 100/210 (47%), Gaps = 14/210 (6%) Query: 8 RADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRV-RVQTGEEGMPLSTIREVAVLR 66 R +++ ++G G +G+VF+ L VA+K + R + M S I+ + LR Sbjct: 3 RPREEFTLCRKLGSGYFGEVFEG--LWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLR 60 Query: 67 HLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMM 126 H VV + D + T+ K +L+ D D E +P + D+ Sbjct: 61 HKHILALYAVVSVGDPVYII-TELMAKGSLLELLRDSD---------EKVLPVSELLDIA 110 Query: 127 FQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTS-VVVTLWY 185 +Q+ G+ +L S +HRDL +NILV + K+ DFGLAR+ + L+ + + Sbjct: 111 WQVAEGMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKW 170 Query: 186 RAPEVLLQSSYATPVDLWSVGCIFAEMFRR 215 APE L + Y+T D+WS G + EMF R Sbjct: 171 TAPEALSRGHYSTKSDVWSFGILLHEMFSR 200 >4PWN-A nrPDB Length = 274 Score = 75.9 bits (185), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 72/300 (24%), Positives = 124/300 (41%), Gaps = 53/300 (17%) Query: 29 KARDLKNGGRF----VALKRVRVQTGEEGMPLSTIREVAVLR------------------ 66 KA + N GRF + + R +T +G+ T EVA Sbjct: 1 KAVGMSNDGRFLKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEA 60 Query: 67 -HLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDM 125 L+ +HPN+VR +D + ++ + + L TYL + + + ++ Sbjct: 61 EMLKGLQHPNIVRFYDSWESTVKGKKCIVLVTELMTSGTLKTYLKRFKV--MKIKVLRSW 118 Query: 126 MFQLLRGLDFLHSHR--VVHRDLKPQNILVTS-SGQIKLADFGLARIYSFQMALTSVVVT 182 Q+L+GL FLH+ ++HRDLK NI +T +G +K+ D GLA + SV+ T Sbjct: 119 CRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLEKRASFAKSVIGT 178 Query: 183 LWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEED 242 + APE + + Y VD+++ G EM + + + Q+ + + P D Sbjct: 179 PEFMAPE-MYEEKYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPASFD 237 Query: 243 WPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQD 302 VA+P K+++ C+ N +R S L+H +FQ+ Sbjct: 238 ---KVAIPEV---------------------KEIIEGCIRQNKDERYSIKDLLNHAFFQE 273 >3FXW-A nrPDB Length = 336 Score = 75.9 bits (185), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 61/240 (25%), Positives = 109/240 (45%), Gaps = 23/240 (9%) Query: 64 VLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIK 123 V H + P++V + DV + L ++ +L + + + + Sbjct: 72 VDHHWQASGGPHIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAA 131 Query: 124 DMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQ---IKLADFGLARIYSFQMALTSVV 180 ++M + + FLHSH + HRD+KP+N+L TS + +KL DFG A+ + Q AL + Sbjct: 132 EIMRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAK-ETTQNALQTPC 190 Query: 181 VTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGE 240 T +Y APEVL Y D+WS+G I + P F ++ G+ + PG Sbjct: 191 YTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGFPPFYSNT-----GQAIS----PGM 241 Query: 241 EDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 + R + L + F + +++ E K L+ L +P +R++ ++HP+ Sbjct: 242 K---RRIRLGQYGFPNPEW-------SEVSEDAKQLIRLLLKTDPTERLTITQFMNHPWI 291 >5B2L-A nrPDB Length = 324 Score = 75.9 bits (185), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 78/298 (26%), Positives = 133/298 (44%), Gaps = 41/298 (13%) Query: 14 ECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEH 73 E + E+G G G+V+K R + G +A+K++R ++G + + ++ V+ L++ + Sbjct: 20 ENLGEMGSGTCGQVWKMR-FRKTGHVIAVKQMR-RSGNKEENKRILMDLDVV--LKSHDC 75 Query: 74 PNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGL 133 P +V+ F ++ TD + L+ ++ L K + +P + M +++ L Sbjct: 76 PYIVQCFGT-FITNTDVFIAMELMGTSAEK-----LKKRMQGPIPERILGKMTVAIVKAL 129 Query: 134 DFL-HSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVL- 191 +L H V+HRD+KP NIL+ GQIKL DFG++ A T Y APE + Sbjct: 130 YYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERID 189 Query: 192 ----LQSSYATPVDLWSVGCIFAEMFRRK-PLFRGSSDVDQLGKILDVIGLPGEEDWPRD 246 + Y D+WS+G E+ + P +D + L K+L +E+ P Sbjct: 190 PPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVL-------QEEPP-- 240 Query: 247 VALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLE 304 LP H + + FV D CLT + KR L H + + E Sbjct: 241 -LLPG---HMGFSGDFQSFVKD-----------CLTKDHRKRPKYNKLLEHSFIKRYE 283 >4NIF-A nrPDB Length = 333 Score = 75.9 bits (185), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 76/265 (28%), Positives = 117/265 (44%), Gaps = 47/265 (17%) Query: 61 EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTE 120 E+ +L L +HPN++ L DV D + LV E + LDK+ +E Sbjct: 51 EIEIL--LRYGQHPNIITLKDV-----YDDGKHVYLVTELMRGG--ELLDKILRQKFFSE 101 Query: 121 TIKDMMFQLL-RGLDFLHSHRVVHRDLKPQNIL-VTSSGQ---IKLADFGLAR-IYSFQM 174 + + + +++LHS VVHRDLKP NIL V SG +++ DFG A+ + + Sbjct: 102 REASFVLHTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENG 161 Query: 175 ALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILD 233 L + T + APEVL + Y D+WS+G + M P G SD + +IL Sbjct: 162 LLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPE--EILT 219 Query: 234 VIG-----LPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKR 288 IG L G +W + E KDL+ K L +P +R Sbjct: 220 RIGSGKFTLSG-GNW-----------------------NTVSETAKDLVSKMLHVDPHQR 255 Query: 289 ISAYSALSHPYFQDLERCKENLDSH 313 ++A L HP+ ++ ++ SH Sbjct: 256 LTAKQVLQHPWVTQKDKLPQSQLSH 280 >3UC3-A nrPDB Length = 361 Score = 75.9 bits (185), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 76/293 (25%), Positives = 121/293 (41%), Gaps = 39/293 (13%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETF 71 +Y+ V +IG G +G RD K VA+K + E G + + ++ H + Sbjct: 21 RYDFVKDIGSGNFGVARLMRD-KLTKELVAVKYI-----ERGAAIDENVQREIINH-RSL 73 Query: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQ-LL 130 HPN+VR +V T L ++ E+ +++ G +E FQ LL Sbjct: 74 RHPNIVRFKEVILTP-----THLAIIMEYASGG--ELYERICNAGRFSEDEARFFFQQLL 126 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTSS--GQIKLADFGLARIYSFQMALTSVVVTLWYRAP 188 G+ + HS ++ HRDLK +N L+ S ++K+ DFG ++ S V T Y AP Sbjct: 127 SGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAP 186 Query: 189 EVLLQSSYATPV-DLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDV 247 EVLL+ Y + D+WS G M F + K + I L + P D+ Sbjct: 187 EVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRI-LSVKYSIPDDI 245 Query: 248 ALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 + + H L+ + +PA RIS +H +F Sbjct: 246 RISPECCH--------------------LISRIFVADPATRISIPEIKTHSWF 278 >2RIO-A nrPDB Length = 434 Score = 75.5 bits (184), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 83/316 (26%), Positives = 142/316 (44%), Gaps = 73/316 (23%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVR 78 +G G+ G V + GR VA+KR+ + + + E+ +L E+ +HPNV+R Sbjct: 23 LGYGSSGTVVFQGSFQ--GRPVAVKRMLIDFCDIAL-----MEIKLLT--ESDDHPNVIR 73 Query: 79 LFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPGVPTETIK--------DMMFQL 129 + C+ + TDR + L +++ QDL V V E +K ++ Q+ Sbjct: 74 YY--CSET-TDRFLYIALELCNLNLQDL------VESKNVSDENLKLQKEYNPISLLRQI 124 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSG-------------QIKLADFGLARIY-----S 171 G+ LHS +++HRDLKPQNILV++S +I ++DFGL + S Sbjct: 125 ASGVAHLHSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSS 184 Query: 172 FQMALTSVVVTLWYRAPEVLLQSS-------YATPVDLWSVGCIFAEMFRRKPLFRGSSD 224 F+ L + T +RAPE+L +S+ +D++S+GC+F + + Sbjct: 185 FRTNLNNPSGTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSK--------- 235 Query: 225 VDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFN 284 GK P + + R+ + R F + + + DL+ + + + Sbjct: 236 ----GK------HPFGDKYSRESNIIRGIFSLDEMKCLHD--RSLIAEATDLISQMIDHD 283 Query: 285 PAKRISAYSALSHPYF 300 P KR +A L HP F Sbjct: 284 PLKRPTAMKVLRHPLF 299 >3ZUT-A nrPDB Length = 362 Score = 75.5 bits (184), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 62/206 (30%), Positives = 94/206 (45%), Gaps = 18/206 (8%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETF 71 +YE V +IG G +G RD K VA+K + E G + + ++ H + Sbjct: 20 RYELVKDIGSGNFGVARLMRD-KQSNELVAVKYI-----ERGEKIDENVKREIINH-RSL 72 Query: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQ-LL 130 HPN+VR +V T L +V E+ +++ G +E FQ L+ Sbjct: 73 RHPNIVRFKEVILTP-----THLAIVMEYASG--GELFERICNAGRFSEDEARFFFQQLI 125 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTSS--GQIKLADFGLARIYSFQMALTSVVVTLWYRAP 188 G+ + H+ +V HRDLK +N L+ S ++K+ FG ++ S V T Y AP Sbjct: 126 SGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICAFGYSKSSVLHSQPKSTVGTPAYIAP 185 Query: 189 EVLLQSSYATPV-DLWSVGCIFAEMF 213 EVLL+ Y V D+WS G M Sbjct: 186 EVLLKKEYDGKVADVWSCGVTLYVML 211 >2OZA-A nrPDB Length = 356 Score = 75.1 bits (183), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 61/205 (29%), Positives = 100/205 (48%), Gaps = 15/205 (7%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVR 78 +G G GKV + + + +F ALK + + P + REV + H + P++VR Sbjct: 26 LGLGINGKVLQIFNKRTQEKF-ALKML------QDCPKAR-REVEL--HWRASQCPHIVR 75 Query: 79 LFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLH 137 + DV R+ L +V E +D +L + + + ++M + + +LH Sbjct: 76 IVDVYENLYAGRKC-LLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 134 Query: 138 SHRVVHRDLKPQNILVTS---SGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQS 194 S + HRD+KP+N+L TS + +KL DFG A+ + +LT+ T +Y APEVL Sbjct: 135 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPE 194 Query: 195 SYATPVDLWSVGCIFAEMFRRKPLF 219 Y D+WS+G I + P F Sbjct: 195 KYDKSCDMWSLGVIMYILLCGYPPF 219 >1NY3-A nrPDB Length = 400 Score = 75.1 bits (183), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 61/205 (29%), Positives = 100/205 (48%), Gaps = 15/205 (7%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVR 78 +G G GKV + + + +F ALK + + P + REV + H + P++VR Sbjct: 70 LGLGINGKVLQIFNKRTQEKF-ALKML------QDCPKAR-REVEL--HWRASQCPHIVR 119 Query: 79 LFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLH 137 + DV R+ L +V E +D +L + + + ++M + + +LH Sbjct: 120 IVDVYENLYAGRKC-LLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 178 Query: 138 SHRVVHRDLKPQNILVTS---SGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQS 194 S + HRD+KP+N+L TS + +KL DFG A+ + +LT+ T +Y APEVL Sbjct: 179 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPE 238 Query: 195 SYATPVDLWSVGCIFAEMFRRKPLF 219 Y D+WS+G I + P F Sbjct: 239 KYDKSCDMWSLGVIMYILLCGYPPF 263 >3NYO-A nrPDB Length = 576 Score = 75.1 bits (183), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 55/205 (26%), Positives = 86/205 (41%), Gaps = 28/205 (13%) Query: 104 DLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLAD 163 DL ++ + + G P ++ GL+ LH R+V+RDLKP+NIL+ G I+++D Sbjct: 270 DLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISD 329 Query: 164 FGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSS 223 GLA + V T+ Y APEV+ Y D W++GC+ EM G S Sbjct: 330 LGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEM------IAGQS 383 Query: 224 DVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTF 283 Q R + R+ + E++ + L + L Sbjct: 384 PFQQ-----------------RKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCK 426 Query: 284 NPAKRI-----SAYSALSHPYFQDL 303 +PA+R+ SA HP F+ L Sbjct: 427 DPAERLGCRGGSAREVKEHPLFKKL 451 >6NPU-A nrPDB Length = 298 Score = 75.1 bits (183), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 55/198 (27%), Positives = 98/198 (49%), Gaps = 15/198 (7%) Query: 18 EIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVV 77 ++G G YG+V++ K VA+K ++ T E ++E AV++ ++ HPN+V Sbjct: 33 KLGGGQYGEVYEGV-WKKYSLTVAVKTLKEDTMEVE---EFLKEAAVMKEIK---HPNLV 85 Query: 78 RLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFL 136 +L VCT RE ++ E + +L YL + V + M Q+ +++L Sbjct: 86 QLLGVCT-----REPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYL 140 Query: 137 HSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYS--FQMALTSVVVTLWYRAPEVLLQS 194 +HRDL +N LV + +K+ADFGL+R+ + A + + APE L + Sbjct: 141 EKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYN 200 Query: 195 SYATPVDLWSVGCIFAEM 212 ++ D+W+ G + E+ Sbjct: 201 KFSIKSDVWAFGVLLWEI 218 >6B2Q-A nrPDB Length = 317 Score = 74.7 bits (182), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 62/206 (30%), Positives = 98/206 (47%), Gaps = 8/206 (3%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVR 78 I G G+V++A D + G R VA+K ++ + + P R A R HP + Sbjct: 40 IATGGMGQVWEAVDNRLG-RRVAVKVLKSEFSSD--PEFIERFRAEARTTAMLNHPGIAS 96 Query: 79 LFDVCTVSRTDRETKLTLVFEHVDQD-LTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLH 137 + D LV E V+ + L + L + + DM+ Q R L H Sbjct: 97 VHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGR--LSLRHALDMLEQTGRALQIAH 154 Query: 138 SHRVVHRDLKPQNILVTSSGQIKLADFGLAR-IYSFQMALTSVVV-TLWYRAPEVLLQSS 195 + +VHRD+KP NIL+T +GQ+K+ DFG+A+ + + + T +V+ T Y APE L Sbjct: 155 AAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQALGHD 214 Query: 196 YATPVDLWSVGCIFAEMFRRKPLFRG 221 + D++S+G + E K F G Sbjct: 215 ASPASDVYSLGVVGYEAVSGKRPFAG 240 >4OW8-A nrPDB Length = 283 Score = 74.3 bits (181), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 63/213 (29%), Positives = 100/213 (46%), Gaps = 8/213 (3%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETF 71 +Y I G G+V++A D + G R VA+K ++ + + P R A R Sbjct: 12 RYRLQRLIATGGMGQVWEAVDNRLG-RRVAVKVLKSEFSSD--PEFIERFRAEARTTAML 68 Query: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQD-LTTYLDKVPEPGVPTETIKDMMFQLL 130 HP + + D LV E V+ + L + L + + DM+ Q Sbjct: 69 NHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGR--LSLRHALDMLEQTG 126 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLAR-IYSFQMALTSVVV-TLWYRAP 188 R L H+ +VHRD+KP NIL+T +GQ+K+ DFG+A+ + + + T +V+ T Y AP Sbjct: 127 RALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAP 186 Query: 189 EVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRG 221 E L + D++S+G + E K F G Sbjct: 187 EQALGHDASPASDVYSLGVVGYEAVSGKRPFAG 219 >4XEY-B nrPDB Length = 408 Score = 74.3 bits (181), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 55/198 (27%), Positives = 98/198 (49%), Gaps = 15/198 (7%) Query: 18 EIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVV 77 ++G G YG+V++ K VA+K ++ T E ++E AV++ ++ HPN+V Sbjct: 132 KLGGGQYGEVYEGV-WKKYSLTVAVKTLKEDTMEVE---EFLKEAAVMKEIK---HPNLV 184 Query: 78 RLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFL 136 +L VCT RE ++ E + +L YL + V + M Q+ +++L Sbjct: 185 QLLGVCT-----REPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYL 239 Query: 137 HSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYS--FQMALTSVVVTLWYRAPEVLLQS 194 +HRDL +N LV + +K+ADFGL+R+ + A + + APE L + Sbjct: 240 EKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYN 299 Query: 195 SYATPVDLWSVGCIFAEM 212 ++ D+W+ G + E+ Sbjct: 300 KFSIKSDVWAFGVLLWEI 317 >3KA0-A nrPDB Length = 320 Score = 74.3 bits (181), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 61/205 (29%), Positives = 99/205 (48%), Gaps = 15/205 (7%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVR 78 +G G GKV + + + +F ALK + + P + REV + H + P++VR Sbjct: 24 LGLGINGKVLQIFNKRTQEKF-ALKML------QDCPKAR-REVEL--HWRASQCPHIVR 73 Query: 79 LFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLH 137 + DV R+ L +V E +D +L + + + ++M + + +LH Sbjct: 74 IVDVYENLYAGRKC-LLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 132 Query: 138 SHRVVHRDLKPQNILVTS---SGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQS 194 S + HRD+KP+N+L TS + +KL DFG A+ + +LT T +Y APEVL Sbjct: 133 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTEPCYTPYYVAPEVLGPE 192 Query: 195 SYATPVDLWSVGCIFAEMFRRKPLF 219 Y D+WS+G I + P F Sbjct: 193 KYDKSCDMWSLGVIMYILLCGYPPF 217 >4X3F-A nrPDB Length = 337 Score = 74.3 bits (181), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 62/206 (30%), Positives = 98/206 (47%), Gaps = 8/206 (3%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVR 78 I G G+V++A D + G R VA+K ++ + + P R A R HP + Sbjct: 20 IATGGMGQVWEAVDNRLG-RRVAVKVLKSEFSSD--PEFIERFRAEARTTAMLNHPGIAS 76 Query: 79 LFDVCTVSRTDRETKLTLVFEHVDQD-LTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLH 137 + D LV E V+ + L + L + + DM+ Q R L H Sbjct: 77 VHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGR--LSLRHALDMLEQTGRALQIAH 134 Query: 138 SHRVVHRDLKPQNILVTSSGQIKLADFGLAR-IYSFQMALTSVVV-TLWYRAPEVLLQSS 195 + +VHRD+KP NIL+T +GQ+K+ DFG+A+ + + + T +V+ T Y APE L Sbjct: 135 AAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQALGHD 194 Query: 196 YATPVDLWSVGCIFAEMFRRKPLFRG 221 + D++S+G + E K F G Sbjct: 195 ASPASDVYSLGVVGYEAVSGKRPFAG 220 >5IG1-A nrPDB Length = 344 Score = 73.9 bits (180), Expect = 8e-14, Method: Compositional matrix adjust. Identities = 74/286 (25%), Positives = 119/286 (41%), Gaps = 38/286 (13%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVR 78 IG+GA+ V + + K G A+K + +++ RE+ + L+ H ++V Sbjct: 25 IGKGAFSTVHRCVN-KRTGEVCAVKVIALKSLRSSEINKIKREIGICSSLQ---HEHIV- 79 Query: 79 LFDVCTVSRTDR-ETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLH 137 ++ R R E+ LVFE+V + + V + M Q+L L H Sbjct: 80 -----SMRRAFRDESHFYLVFEYVSGG-ELFDEIVTRKFYNEKDASACMHQILSALQHCH 133 Query: 138 SHRVVHRDLKPQNILVTS---SGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQS 194 S ++HRDLKP+N+L+ S + +K+ DFGLA I T Y +PEV+ + Sbjct: 134 SKNIIHRDLKPENLLLASKDPNAPVKITDFGLAVIMEQGPTYFGFAGTPGYLSPEVIRRV 193 Query: 195 SYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAF 254 Y T VD+W+ G I + P F EED + A + Sbjct: 194 PYDTAVDVWACGVILYILLVGYPPF-------------------WEEDHQKLYAQIKNCQ 234 Query: 255 HSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 + + + T EL K +L NP +R + L HP+ Sbjct: 235 YDFPSPEWDSVTTAAKELIKAMLEP----NPKRRPTVQELLQHPWI 276 >3DB8-A nrPDB Length = 317 Score = 73.9 bits (180), Expect = 8e-14, Method: Compositional matrix adjust. Identities = 38/99 (38%), Positives = 56/99 (56%), Gaps = 1/99 (1%) Query: 125 MMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTS-VVVTL 183 M Q ++G+ +LH++RV+HRDLK N+ + +K+ DFGLA F + T Sbjct: 147 FMRQTIQGVQYLHNNRVIHRDLKLGNLFLNDDMDVKIGDFGLATKIEFDGERKKDLCGTP 206 Query: 184 WYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGS 222 Y APEVL + ++ VD+WS+GCI + KP F S Sbjct: 207 NYIAPEVLCKKGHSFEVDIWSLGCILYTLLVGKPPFETS 245 >5L6P-A nrPDB Length = 298 Score = 73.9 bits (180), Expect = 8e-14, Method: Compositional matrix adjust. Identities = 57/205 (27%), Positives = 98/205 (47%), Gaps = 21/205 (10%) Query: 19 IGEGAYGKVFKARDLKNGGR---FVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPN 75 IG G +G+V + R LK GR FVA+K ++V E + E +++ F+HPN Sbjct: 27 IGAGEFGEVCRGR-LKQPGRREVFVAIKTLKVGYTER-QRRDFLSEASIMGQ---FDHPN 81 Query: 76 VVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDF 135 ++RL V T SR + ++ E ++ ++ + + M+ + G+ + Sbjct: 82 IIRLEGVVTKSR-----PVMILTEFMENCALDSFLRLNDGQFTVIQLVGMLRGIAAGMKY 136 Query: 136 LHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY-------SFQMALTSVVVTLWYRAP 188 L VHRDL +NILV S+ K++DFGL+R ++ +L + W AP Sbjct: 137 LSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRW-TAP 195 Query: 189 EVLLQSSYATPVDLWSVGCIFAEMF 213 E + + + D+WS G + E+ Sbjct: 196 EAIAYRKFTSASDVWSYGIVMWEVM 220 >5O2C-A nrPDB Length = 380 Score = 73.9 bits (180), Expect = 8e-14, Method: Compositional matrix adjust. Identities = 74/292 (25%), Positives = 132/292 (45%), Gaps = 43/292 (14%) Query: 18 EIGEGAYGKVFKARDLKNGGR--FVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPN 75 E+G GA+ V+K D + + L+ ++ E+ +E A + L+ +HPN Sbjct: 32 ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQ----QRFKEEAEM--LKGLQHPN 85 Query: 76 VVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLD--KVPEPGVPTETIKDMMFQLLRGL 133 +VR +D ++ + + L TYL KV +P V ++ Q+L+GL Sbjct: 86 IVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKV----LRSWCRQILKGL 141 Query: 134 DFLHSHR--VVHRDLKPQNILVTS-SGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEV 190 FLH+ ++HRDLK NI +T +G +K+ D GLA + A SV+ T + APE Sbjct: 142 QFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFA-KSVIGTPEFMAPE- 199 Query: 191 LLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALP 250 + + Y VD+++ G EM + + + Q+ + + P Sbjct: 200 MYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPA----------- 248 Query: 251 RQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQD 302 +F+ VTD + K+++ C+ N ++R+S L+H +F + Sbjct: 249 --SFNK---------VTDPE--VKEIIEGCIRQNKSERLSIRDLLNHAFFAE 287 >5N23-A nrPDB Length = 352 Score = 73.9 bits (180), Expect = 9e-14, Method: Compositional matrix adjust. Identities = 56/223 (25%), Positives = 106/223 (47%), Gaps = 14/223 (6%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLE-T 70 Q+E + +G G++G+V + + G + +++ ++ + L I + ++ Sbjct: 43 QFERIRTLGTGSFGRVMLVKHKETGNHYA----MKILDKQKVVKLKQIEHTLNEKRIQQA 98 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPGVPTETIKDMMFQL 129 P +V+L S D + L +V E+ ++ ++L ++ P Q+ Sbjct: 99 VNFPFLVKL----EFSFKDN-SNLYMVLEYAPGGEMFSHLRRIGRFSEPHARF--YAAQI 151 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPE 189 + ++LHS +++RDLKP+N+L+ G IK+ADFG A+ + T + T Y APE Sbjct: 152 VLTFEYLHSLDLIYRDLKPENLLIDQQGYIKVADFGFAKRVKGRTPWT-LCGTPEYLAPE 210 Query: 190 VLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKIL 232 ++L Y VD W++G + EM P F + KI+ Sbjct: 211 IILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIV 253 >4UYA-A nrPDB Length = 340 Score = 73.9 bits (180), Expect = 9e-14, Method: Compositional matrix adjust. Identities = 58/215 (26%), Positives = 97/215 (45%), Gaps = 25/215 (11%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLS-TIREVAVLRHLETFEHPNVV 77 IG G +G+V++A G+ VA+K R ++ + ++R A R HPN++ Sbjct: 34 IGAGGFGQVYRA---TWQGQEVAVKAARQDPEQDAAAAAESVRREA--RLFAMLRHPNII 88 Query: 78 RLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLH 137 L VC ++ L LV E + +P + + Q+ RG+ +LH Sbjct: 89 ELRGVCL-----QQPHLCLVLEFARGGALN--RALAGRRIPPHVLVNWAVQIARGMLYLH 141 Query: 138 SHR---VVHRDLKPQNILV--------TSSGQIKLADFGLARIYSFQMALTSVVVTLWYR 186 ++HRDLK NIL+ + +K+ DFGLAR + + + W Sbjct: 142 EEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTKMATAGAYAWM- 200 Query: 187 APEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRG 221 APEV+ S ++ D+WS G + E+ + +RG Sbjct: 201 APEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRG 235 >4RA4-A nrPDB Length = 355 Score = 73.9 bits (180), Expect = 9e-14, Method: Compositional matrix adjust. Identities = 61/221 (27%), Positives = 102/221 (46%), Gaps = 19/221 (8%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVR--VQTGEEGMPLSTIREVAVLRHLETFEHPNV 76 +G+G++GKV A D K A+K ++ V ++ + + + + R L + P Sbjct: 28 LGKGSFGKVMLA-DRKGTEELYAIKILKKDVVIQDDDVECTMVEK----RVLALLDKPPF 82 Query: 77 VRLFDVC--TVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQLLRGL 133 + C TV R L V E+V+ DL ++ +V + P + GL Sbjct: 83 LTQLHSCFQTVDR------LYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISI--GL 134 Query: 134 DFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVV-TLWYRAPEVLL 192 FLH +++RDLK N+++ S G IK+ADFG+ + + T T Y APE++ Sbjct: 135 FFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIA 194 Query: 193 QSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILD 233 Y VD W+ G + EM +P F G + + I++ Sbjct: 195 YQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIME 235 >5O2B-A nrPDB Length = 285 Score = 73.9 bits (180), Expect = 9e-14, Method: Compositional matrix adjust. Identities = 73/294 (24%), Positives = 126/294 (42%), Gaps = 47/294 (15%) Query: 18 EIGEGAYGKVFKARDLKNGGR--FVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPN 75 E+G GA+ V+K D + + L+ ++ E+ +E A + L+ +HPN Sbjct: 23 ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQ----QRFKEEAEM--LKGLQHPN 76 Query: 76 VVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLD--KVPEPGVPTETIKDMMFQLLRGL 133 +VR +D ++ + + L TYL KV +P V ++ Q+L+GL Sbjct: 77 IVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKV----LRSWCRQILKGL 132 Query: 134 DFLHSHR--VVHRDLKPQNILVTS-SGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEV 190 FLH+ ++HRDLK NI +T +G +K+ D GLA + A SV+ T + APE Sbjct: 133 QFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFA-KSVIGTPEFMAPE- 190 Query: 191 LLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALP 250 + + Y VD+++ G EM ++P Sbjct: 191 MYEEHYDESVDVYAFGMCMLEM--------------------------ATSEYPYSECQN 224 Query: 251 RQAFHSKSAQPIE--KFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQD 302 + K I+ F D K+++ C+ N ++R+S L+H +F + Sbjct: 225 AAQIYRKVTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAE 278 >2XYN-A nrPDB Length = 292 Score = 73.9 bits (180), Expect = 9e-14, Method: Compositional matrix adjust. Identities = 55/198 (27%), Positives = 99/198 (50%), Gaps = 15/198 (7%) Query: 18 EIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVV 77 ++G G YG+V+ K VA+K ++ T E ++E AV++ ++ HPN+V Sbjct: 39 KLGGGQYGEVYVGV-WKKYSLTVAVKTLKEDTMEVE---EFLKEAAVMKEIK---HPNLV 91 Query: 78 RLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFL 136 +L VCT+ E +V E++ +L YL + V + M Q+ +++L Sbjct: 92 QLLGVCTL-----EPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYL 146 Query: 137 HSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYS--FQMALTSVVVTLWYRAPEVLLQS 194 +HRDL +N LV + +K+ADFGL+R+ + A + + APE L + Sbjct: 147 EKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYN 206 Query: 195 SYATPVDLWSVGCIFAEM 212 +++ D+W+ G + E+ Sbjct: 207 TFSIKSDVWAFGVLLWEI 224 >4B6L-A nrPDB Length = 281 Score = 73.9 bits (180), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 53/212 (25%), Positives = 99/212 (46%), Gaps = 30/212 (14%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLR-----HLETFEH 73 +G+G + + ++A D + G + + + + + E+ + R H+ F H Sbjct: 17 LGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVRFSH 76 Query: 74 -----PNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQ 128 N+ ++C+ R++ H+ + T L+ PE ++ + Q Sbjct: 77 HFEDADNIYIFLELCS-----RKS-----LAHIWKARHTLLE--PE-------VRYYLRQ 117 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGL-ARIYSFQMALTSVVVTLWYRA 187 +L GL +LH ++HRDLK N +T + ++K+ DFGL AR+ + ++ T Y A Sbjct: 118 ILSGLKYLHQRGILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVA 177 Query: 188 PEVLLQSSYATPVDLWSVGCIFAEMFRRKPLF 219 PEVLL+ + D+WS+GC+ + P F Sbjct: 178 PEVLLRQGHGPEADVWSLGCVMYTLLCGSPPF 209 >3QUP-A nrPDB Length = 323 Score = 73.9 bits (180), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 58/218 (26%), Positives = 101/218 (46%), Gaps = 16/218 (7%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFV--ALKRVRVQTGEEGMPLSTIREVAVLRH 67 +QQ+ +G+G +G V +A+ + G FV A+K ++ +RE A ++ Sbjct: 22 EQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKE 81 Query: 68 LETFEHPNVVRLFDVCTVSRTDRETKLTLV----FEHVDQDLTTYLDKVPEP--GVPTET 121 F+HP+V +L V SR + +V +H D ++ E +P +T Sbjct: 82 ---FDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQT 138 Query: 122 IKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLAR-IYS---FQMALT 177 + M + G+++L S +HRDL +N ++ + +ADFGL+R IYS ++ Sbjct: 139 LVRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCA 198 Query: 178 SVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRR 215 S + W A E L + Y D+W+ G E+ R Sbjct: 199 SKLPVKWL-ALESLADNLYTVHSDVWAFGVTMWEIMTR 235 >3SXS-A nrPDB Length = 268 Score = 73.9 bits (180), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 56/205 (27%), Positives = 98/205 (47%), Gaps = 25/205 (12%) Query: 16 VAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET---FE 72 + E+G G +G V G++ V V+ +EG ++ E + +T Sbjct: 13 LKELGSGQFGVV-------KLGKWKGQYDVAVKMIKEG----SMSEDEFFQEAQTMMKLS 61 Query: 73 HPNVVRLFDVCTVSRTDRETKLTLVFEHVDQD-LTTYLDKVPEPGVPTETIKDMMFQLLR 131 HP +V+ + VC+ +E + +V E++ L YL + G+ + +M + + Sbjct: 62 HPKLVKFYGVCS-----KEYPIYIVTEYISNGCLLNYL-RSHGKGLEPSQLLEMCYDVCE 115 Query: 132 GLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLW---YRAP 188 G+ FL SH+ +HRDL +N LV +K++DFG+ R Y S V T + + AP Sbjct: 116 GMAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTR-YVLDDQYVSSVGTKFPVKWSAP 174 Query: 189 EVLLQSSYATPVDLWSVGCIFAEMF 213 EV Y++ D+W+ G + E+F Sbjct: 175 EVFHYFKYSSKSDVWAFGILMWEVF 199 >6FER-A nrPDB Length = 309 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 60/224 (26%), Positives = 103/224 (45%), Gaps = 38/224 (16%) Query: 18 EIGEGAYGKV----------FKARDLK-----NGGRFVALKRVRVQTGEEGMPLSTIREV 62 ++GEG +G+V FK +D N VA+K +R + ++E+ Sbjct: 16 KLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARN-DFLKEI 74 Query: 63 AVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPG----- 116 ++ L+ PN++ L VC + L ++ E+++ DL +L + P Sbjct: 75 KIMSRLK---DPNIIHLLAVCIT-----DDPLCMITEYMENGDLNQFLSRHEPPNSSSSD 126 Query: 117 ---VPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLAR-IYS- 171 V +K M Q+ G+ +L S VHRDL +N LV + IK+ADFG++R +YS Sbjct: 127 VRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSG 186 Query: 172 --FQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMF 213 +++ +V+ W +LL + T D+W+ G E F Sbjct: 187 DYYRIQGRAVLPIRWMSWESILL-GKFTTASDVWAFGVTLWETF 229 >5KMM-A nrPDB Length = 329 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 69/231 (29%), Positives = 111/231 (48%), Gaps = 37/231 (16%) Query: 18 EIGEGAYGKVFKA--RDL--KNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEH 73 E+GEGA+GKVF A +L + VA+K ++ E RE +L L+ H Sbjct: 42 ELGEGAFGKVFLAECHNLLPEQDKMLVAVKALK--EASESARQDFQREAELLTMLQ---H 96 Query: 74 PNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYL--------------DKVPEPGVP 118 ++VR F VCT R L +VFE++ DL +L D P P + Sbjct: 97 QHIVRFFGVCTEGRP-----LLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGP-LG 150 Query: 119 TETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLAR-IYS---FQM 174 + + Q+ G+ +L VHRDL +N LV +K+ DFG++R IYS +++ Sbjct: 151 LGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRV 210 Query: 175 ALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFR--RKPLFRGSS 223 +++ W PE +L + T D+WS G + E+F ++P ++ S+ Sbjct: 211 GGRTMLPIRWM-PPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSN 260 >4JG6-A nrPDB Length = 355 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 70/246 (28%), Positives = 109/246 (44%), Gaps = 35/246 (14%) Query: 61 EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTE 120 E+ +L L +HPN++ L DV D + +V E + LDK+ +E Sbjct: 78 EIEIL--LRYGQHPNIITLKDV-----YDDGKYVYVVTELMKGG--ELLDKILRQKFFSE 128 Query: 121 -TIKDMMFQLLRGLDFLHSHRVVHRDLKPQNIL-VTSSGQ---IKLADFGLAR-IYSFQM 174 ++F + + +++LH+ VVHRDLKP NIL V SG I++ DFG A+ + + Sbjct: 129 REASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENG 188 Query: 175 ALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDV 234 L + T + APEVL + Y D+WS+G + M F D D +IL Sbjct: 189 LLMTPCYTANFVAPEVLERQGYDAACDIWSLGVLLYTMLTGYTPFANGPD-DTPEEILAR 247 Query: 235 IGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSA 294 IG S + + + KDL+ K L +P +R++A Sbjct: 248 IG-------------------SGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALV 288 Query: 295 LSHPYF 300 L HP+ Sbjct: 289 LRHPWI 294 >4WB7-A nrPDB Length = 405 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 56/223 (25%), Positives = 107/223 (47%), Gaps = 15/223 (6%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIRE-VAVLRHLET 70 Q+E + +G G++G+V + + G + +++ ++ + L I + R L+ Sbjct: 97 QFERIKTLGTGSFGRVMLVKHKETGNHYA----MKILDKQKVVKLKQIEHTLNEKRILQA 152 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPGVPTETIKDMMFQL 129 P +V+L S D + L +V E+V ++ ++L ++ P Q+ Sbjct: 153 VNFPFLVKL----EFSFKDN-SNLYMVMEYVPGGEMFSHLRRIGRFSEPHARF--YAAQI 205 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPE 189 + ++LHS +++RDLKP+N+L+ G I++ DFG A+ + ++ T Y APE Sbjct: 206 VLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAK--RVKGRTWTLCGTPEYLAPE 263 Query: 190 VLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKIL 232 ++L Y VD W++G + EM P F + KI+ Sbjct: 264 IILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIV 306 >3LZB-A nrPDB Length = 327 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 59/223 (26%), Positives = 101/223 (45%), Gaps = 32/223 (14%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRF---VALKRVRVQTGEEGMPLSTIREVAVLR 66 + +++ + +G GA+G V+K + G + VA+K +R T + + E V+ Sbjct: 14 ETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANK-EILDEAYVM- 71 Query: 67 HLETFEHPNVVRLFDVCTVSRTDRETKLT-------LVFEHVDQDLTTYLDKVPEPGVPT 119 + ++P+V RL +C S T+L V EH D + YL Sbjct: 72 --ASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYL---------- 119 Query: 120 ETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSF---QMAL 176 + Q+ +G+++L R+VHRDL +N+LV + +K+ DFGLA++ + Sbjct: 120 ---LNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHA 176 Query: 177 TSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEM--FRRKP 217 V + + A E +L Y D+WS G E+ F KP Sbjct: 177 EGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKP 219 >4AW2-A nrPDB Length = 437 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 69/238 (28%), Positives = 111/238 (46%), Gaps = 31/238 (13%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 + +E + IG GA+G+V + LKN + A+K + + +L+ ET Sbjct: 74 EDFEILKVIGRGAFGEVAVVK-LKNADKVFAMK--------------ILNKWEMLKRAET 118 Query: 71 F---EHPNVVRLFDVCTVSRT----DRETKLTLVFEH-VDQDLTTYLDKVPEPGVPTETI 122 E +V+ D ++ + L LV ++ V DL T L K E +P E Sbjct: 119 ACFREERDVLVNGDSKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKF-EDRLPEEMA 177 Query: 123 KDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFG-LARIYSFQMALTSVVV 181 + + +++ +D +H VHRD+KP NIL+ +G I+LADFG ++ +SV V Sbjct: 178 RFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAV 237 Query: 182 -TLWYRAPEVLL-----QSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILD 233 T Y +PE+L + Y D WS+G EM + F S V+ GKI++ Sbjct: 238 GTPDYISPEILQAMEGGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMN 295 >6CTH-A nrPDB Length = 309 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 61/216 (28%), Positives = 106/216 (49%), Gaps = 24/216 (11%) Query: 6 LCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVL 65 L + + ++GEG +G V++ L++ ++A+K+V + ++G+ EV ++ Sbjct: 10 LAKVTSNFNAENKLGEGGFGSVYRGF-LRDSDTYIAVKKVS-RASKQGIK-EYASEVKII 66 Query: 66 RHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDK---VPEPGVPTET 121 L H N+V+L C +L LV+E + + L +++ K + V Sbjct: 67 SRLR---HKNLVKLIGWC-----HERGELMLVYEFMANGSLDSHIFKGKSLLTWEVRYRI 118 Query: 122 IKDMMFQLLRGLDFLHS---HRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTS 178 +KD+ LL +LH H V+HRD+K NI++ SS KL DFGLAR+ L Sbjct: 119 VKDLASALL----YLHEEGDHCVLHRDIKTSNIMLDSSFNAKLGDFGLARLVDHAKGLKK 174 Query: 179 VVV--TLWYRAPEVLLQSSYATPVDLWSVGCIFAEM 212 ++ T+ Y APE L + D++S G + E+ Sbjct: 175 TLLAGTVGYMAPECLSSGKASKESDVYSFGVVALEI 210 >4XI2-A nrPDB Length = 446 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 57/202 (28%), Positives = 102/202 (50%), Gaps = 19/202 (9%) Query: 16 VAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPN 75 + E+G G +G V + G VA+K +R + E I E V+ +L H Sbjct: 192 LKELGTGQFGVVKYGK--WRGQYDVAIKMIREGSMSED---EFIEEAKVMMNLS---HEK 243 Query: 76 VVRLFDVCTVSRTDRETKLTLVFEHVDQD-LTTYLDKVPEPGVPTETIKDMMFQLLRGLD 134 +V+L+ VCT R + ++ E++ L YL ++ T+ + +M + ++ Sbjct: 244 LVQLYGVCTKQRP-----IFIITEYMANGCLLNYLREMRHR-FQTQQLLEMCKDVCEAME 297 Query: 135 FLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLW---YRAPEVL 191 +L S + +HRDL +N LV G +K++DFGL+R Y TS V + + + PEVL Sbjct: 298 YLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSR-YVLDDEYTSSVGSKFPVRWSPPEVL 356 Query: 192 LQSSYATPVDLWSVGCIFAEMF 213 + S +++ D+W+ G + E++ Sbjct: 357 MYSKFSSKSDIWAFGVLMWEIY 378 >3TKU-A nrPDB Length = 433 Score = 73.2 bits (178), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 68/238 (28%), Positives = 110/238 (46%), Gaps = 31/238 (13%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 + +E + IG GA+G+V + +KN R A+K + + +L+ ET Sbjct: 90 EDFEIIKVIGRGAFGEVAVVK-MKNTERIYAMK--------------ILNKWEMLKRAET 134 Query: 71 F---EHPNVVRLFDVCTVSRT----DRETKLTLVFEH-VDQDLTTYLDKVPEPGVPTETI 122 E +V+ D ++ E L LV ++ V DL T L K E +P + Sbjct: 135 ACFREERDVLVNGDCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKF-EDKLPEDMA 193 Query: 123 KDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFG-LARIYSFQMALTSVVV 181 + + +++ +D +H VHRD+KP N+L+ +G I+LADFG ++ +SV V Sbjct: 194 RFYIGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAV 253 Query: 182 -TLWYRAPEVLL-----QSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILD 233 T Y +PE+L Y D WS+G EM + F S V+ GKI++ Sbjct: 254 GTPDYISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMN 311 >2FO0-A nrPDB Length = 495 Score = 73.2 bits (178), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 54/198 (27%), Positives = 98/198 (49%), Gaps = 15/198 (7%) Query: 18 EIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVV 77 ++G G YG+V++ K VA+K ++ T E ++E AV++ ++ HPN+V Sbjct: 224 KLGGGQYGEVYEGV-WKKYSLTVAVKTLKEDTME---VEEFLKEAAVMKEIK---HPNLV 276 Query: 78 RLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFL 136 +L VCT RE ++ E + +L YL + V + M Q+ +++L Sbjct: 277 QLLGVCT-----REPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYL 331 Query: 137 HSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQ--MALTSVVVTLWYRAPEVLLQS 194 +HR+L +N LV + +K+ADFGL+R+ + A + + APE L + Sbjct: 332 EKKNFIHRNLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYN 391 Query: 195 SYATPVDLWSVGCIFAEM 212 ++ D+W+ G + E+ Sbjct: 392 KFSIKSDVWAFGVLLWEI 409 >1VZO-A nrPDB Length = 355 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 79/314 (25%), Positives = 141/314 (44%), Gaps = 60/314 (19%) Query: 11 QQYECVAEIGEGAYGKVFKARDLK--NGGRFVALKRVRVQTGEEGMPLS--TIREVAVLR 66 + +E + +G GAYGKVF R + + G+ A+K ++ T + + T E VL Sbjct: 54 ENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLE 113 Query: 67 HLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDM 125 H+ + P +V L ETKL L+ ++++ +L T+L + ++ Sbjct: 114 HIR--QSPFLVTLHYAFQT-----ETKLHLILDYINGGELFTHLSQRER--FTEHEVQIY 164 Query: 126 MFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLA---------RIYSFQMAL 176 + +++ L+ LH +++RD+K +NIL+ S+G + L DFGL+ R Y F Sbjct: 165 VGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYDF---- 220 Query: 177 TSVVVTLWYRAPEVLL--QSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDV 234 T+ Y AP+++ S + VD WS+G + E+ F Sbjct: 221 ---CGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFT-------------- 263 Query: 235 IGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRIS---- 290 + GE++ +++ R+ S+ P E + L KDL+ + L +P KR+ Sbjct: 264 --VDGEKNSQAEIS--RRILKSEPPYPQE-----MSALAKDLIQRLLMKDPKKRLGCGPR 314 Query: 291 -AYSALSHPYFQDL 303 A H +FQ + Sbjct: 315 DADEIKEHLFFQKI 328 >5HVK-A nrPDB Length = 315 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 57/230 (24%), Positives = 104/230 (45%), Gaps = 31/230 (13%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVR 78 +G+G +G+ K + G V + +R +E + ++EV V+R LE HPNV++ Sbjct: 22 LGKGCFGQAIKVTHRETGEVMVMKELIRF---DEETQRTFLKEVKVMRCLE---HPNVLK 75 Query: 79 LFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHS 138 V ++ +L + E++ + K + P + G+ +LHS Sbjct: 76 FIGVLY-----KDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHS 130 Query: 139 HRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALT---------------SVVVTL 183 ++HR+L N LV + + +ADFGLAR+ + +VV Sbjct: 131 MNIIHRNLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNP 190 Query: 184 WYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILD 233 ++ APE++ SY VD++S G + E+ + R ++D D L + +D Sbjct: 191 YWMAPEMINGRSYDEKVDVFSFGIVLCEI-----IGRVNADPDYLPRTMD 235 >2OU7-A nrPDB Length = 335 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 37/96 (38%), Positives = 55/96 (57%), Gaps = 1/96 (1%) Query: 128 QLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVV-TLWYR 186 Q++ G +LH +RV+HRDLK N+ + ++K+ DFGLA + V+ T Y Sbjct: 149 QIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYI 208 Query: 187 APEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGS 222 APEVL + ++ VD+WS+GCI + KP F S Sbjct: 209 APEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETS 244 >2OGV-A nrPDB Length = 317 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 59/211 (27%), Positives = 99/211 (46%), Gaps = 24/211 (11%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALK---RVRVQTGEEGMPLSTIREVAVLRHLETFEHPN 75 +G GA+GKV +A G LK ++ T + + E+ ++ HL +H N Sbjct: 46 LGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLG--QHEN 103 Query: 76 VVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYL------DKVPEPGVPTETIKDMMF- 127 +V L CT + ++ E+ DL +L D E G P E ++D++ Sbjct: 104 IVNLLGACT-----HGGPVLVITEYCCYGDLLNFLRRKAEADLDKEDGRPLE-LRDLLHF 157 Query: 128 --QLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY---SFQMALTSVVVT 182 Q+ +G+ FL S +HRD+ +N+L+T+ K+ DFGLAR S + + + Sbjct: 158 SSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLP 217 Query: 183 LWYRAPEVLLQSSYATPVDLWSVGCIFAEMF 213 + + APE + Y D+WS G + E+F Sbjct: 218 VKWMAPESIFDCVYTVQSDVWSYGILLWEIF 248 >5X3F-B nrPDB Length = 393 Score = 72.4 bits (176), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 55/223 (24%), Positives = 108/223 (48%), Gaps = 15/223 (6%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIRE-VAVLRHLET 70 Q++ + +G G++G+V + ++G + +++ ++ + L I + R L+ Sbjct: 85 QFDRIKTLGTGSFGRVMLVKHKESGNHYA----MKILDKQKVVKLKQIEHTLNEKRILQA 140 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPGVPTETIKDMMFQL 129 P +V+L S D + L +V E+V ++ ++L ++ P Q+ Sbjct: 141 VNFPFLVKL----EFSFKDN-SNLYMVMEYVAGGEMFSHLRRIGRFSEPHARF--YAAQI 193 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPE 189 + ++LHS +++RDLKP+N+L+ G I++ DFG A+ + ++ T Y APE Sbjct: 194 VLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAK--RVKGRTWTLCGTPEYLAPE 251 Query: 190 VLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKIL 232 ++L Y VD W++G + EM P F + KI+ Sbjct: 252 IILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIV 294 >4J52-A nrPDB Length = 293 Score = 72.4 bits (176), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 37/96 (38%), Positives = 55/96 (57%), Gaps = 1/96 (1%) Query: 128 QLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVV-TLWYR 186 Q++ G +LH +RV+HRDLK N+ + ++K+ DFGLA + V+ T Y Sbjct: 122 QIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYI 181 Query: 187 APEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGS 222 APEVL + ++ VD+WS+GCI + KP F S Sbjct: 182 APEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETS 217 >4OLI-A nrPDB Length = 645 Score = 72.4 bits (176), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 61/230 (26%), Positives = 103/230 (44%), Gaps = 23/230 (10%) Query: 16 VAEIGEGAYGKV-FKARDLKNGG--RFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 + ++GEG +GKV D N G VA+K ++ G + +E+ +LR T Sbjct: 358 IRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRS-GWKQEIDILR---TLY 413 Query: 73 HPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRG 132 H ++++ C E L LV E+V L + D +P + + Q+ G Sbjct: 414 HEHIIKYKGCC---EDQGEKSLQLVMEYVP--LGSLRDYLPRHSIGLAQLLLFAQQICEG 468 Query: 133 LDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYS-----FQMALTSVVVTLWYRA 187 + +LHS +HR+L +N+L+ + +K+ DFGLA+ +++ WY A Sbjct: 469 MAYLHSQHYIHRNLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWY-A 527 Query: 188 PEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGL 237 PE L + + D+WS G E+ L S K L++IG+ Sbjct: 528 PECLKEYKFYYASDVWSFGVTLYEL-----LTHCDSSQSPPTKFLELIGI 572 Score = 29.3 bits (64), Expect = 2.6, Method: Compositional matrix adjust. Identities = 26/94 (27%), Positives = 43/94 (45%), Gaps = 12/94 (12%) Query: 128 QLLRGLDFLHSHRVVHRDLKPQNILVTSSGQ-------IKLADFGLARIYSFQMALTSVV 180 QL L +L + +VH ++ +NIL+ G IKL+D G+ ++ V Sbjct: 175 QLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGL---GALSREERV 231 Query: 181 VTLWYRAPEVLL--QSSYATPVDLWSVGCIFAEM 212 + + APE L +S +T +D W G E+ Sbjct: 232 ERIPWLAPECLPGGANSLSTAMDKWGFGATLLEI 265 >5VD3-A nrPDB Length = 311 Score = 72.4 bits (176), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 68/220 (30%), Positives = 94/220 (42%), Gaps = 12/220 (5%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVA-VLRHL 68 Q ++ ++ +G G+YG+VFK R K GR A+KR P R++A V H Sbjct: 56 QQSFQRLSRLGHGSYGEVFKVRS-KEDGRLYAVKR---SMSPFRGPKDRARKLAEVGSHE 111 Query: 69 ETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQ 128 + +HP VRL + L L E L + + +P + + Sbjct: 112 KVGQHPCCVRLEQAW-----EEGGILYLQTELCGPSLQQHCEAW-GASLPEAQVWGYLRD 165 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAP 188 L L LHS +VH D+KP NI + G+ KL DFGL A Y AP Sbjct: 166 TLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAP 225 Query: 189 EVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQL 228 E LLQ SY T D++S+G E+ L G QL Sbjct: 226 E-LLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQL 264 >4CQG-A nrPDB Length = 331 Score = 72.4 bits (176), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 79/311 (25%), Positives = 134/311 (43%), Gaps = 51/311 (16%) Query: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 YE IG G + KV A + G VA+K + +P R + L++ Sbjct: 11 YELYETIGTGGFAKVKLACHVLTG-EMVAIKIMDKNALGSDLP----RVKTEIDALKSLR 65 Query: 73 HPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPGVPTETIKDMMFQLLR 131 H ++ +L+ V + + K+ +V E+ +L Y+ + + + E + + Q+L Sbjct: 66 HQHICQLYHV-----LETKNKIFMVLEYCPGGELFDYI--ISQDRLSEEETRVVFRQILS 118 Query: 132 GLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLA------RIYSFQMALTSVVVTLWY 185 + ++HS HRDLKP+N+L + ++KL DFGL + Y Q S+ Y Sbjct: 119 AVAYVHSQGYAHRDLKPENLLFDENHKLKLIDFGLCAKPKGNKDYHLQECCGSLA----Y 174 Query: 186 RAPEVLLQSSY-ATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWP 244 APE++ SY + D+WS+G + +L LP ++D Sbjct: 175 AAPELIQGKSYLGSEADVWSMGILLY--------------------VLMCGFLPFDDD-- 212 Query: 245 RDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLE 304 +AL ++ K P K+++ L LL + L +P KRIS + L+HP+ Sbjct: 213 NVMALYKKIMRGKYEVP--KWLSPSSIL---LLQQMLQVDPKKRISMRNLLNHPWVMQDY 267 Query: 305 RCKENLDSHLP 315 C S P Sbjct: 268 SCPVEWQSKTP 278 >2DQ7-X nrPDB Length = 283 Score = 72.4 bits (176), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 62/255 (24%), Positives = 118/255 (46%), Gaps = 20/255 (7%) Query: 14 ECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEH 73 + + +G G +G+V+ NG VA+K ++ T P S + E +++ L+ H Sbjct: 12 QLIKRLGNGQFGEVWMGT--WNGNTKVAIKTLKPGTMS---PESFLEEAQIMKKLK---H 63 Query: 74 PNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQLLRG 132 +V+L+ V + E + +V E++++ L +L + + DM Q+ G Sbjct: 64 DKLVQLYAVVS------EEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAG 117 Query: 133 LDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY--SFQMALTSVVVTLWYRAPEV 190 + ++ +HRDL+ NILV + K+ADFGLAR+ + A + + APE Sbjct: 118 MAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEA 177 Query: 191 LLQSSYATPVDLWSVGCIFAEMFRRKPL-FRGSSDVDQLGKILDVIGLPGEEDWPRDVAL 249 L + D+WS G + E+ + + + G ++ + L ++ +P +D P ++L Sbjct: 178 ALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCP--ISL 235 Query: 250 PRQAFHSKSAQPIEK 264 H P E+ Sbjct: 236 HELMIHCWKKDPEER 250 >6DBM-A nrPDB Length = 318 Score = 72.0 bits (175), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 61/230 (26%), Positives = 103/230 (44%), Gaps = 23/230 (10%) Query: 16 VAEIGEGAYGKV-FKARDLKNGG--RFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 + ++GEG +GKV D N G VA+K ++ G + +E+ +LR T Sbjct: 36 IRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAGPQHRS-GWKQEIDILR---TLY 91 Query: 73 HPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRG 132 H ++++ C + L LV E+V L + D +P + + Q+ G Sbjct: 92 HEHIIKYKGCCEDAGA---ASLQLVMEYVP--LGSLRDYLPRHSIGLAQLLLFAQQICEG 146 Query: 133 LDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYS-----FQMALTSVVVTLWYRA 187 + +LHS +HRDL +N+L+ + +K+ DFGLA+ +++ WY A Sbjct: 147 MAYLHSQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWY-A 205 Query: 188 PEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGL 237 PE L + + D+WS G E+ L S K L++IG+ Sbjct: 206 PECLKEYKFYYASDVWSFGVTLYEL-----LTHCDSSQSPPTKFLELIGI 250 >3A4O-X nrPDB Length = 286 Score = 72.0 bits (175), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 63/250 (25%), Positives = 114/250 (45%), Gaps = 17/250 (6%) Query: 2 EKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIRE 61 +KD + + V +G G +G+V+ N VA+K ++ T M + E Sbjct: 4 DKDAWEIPRESIKLVKRLGAGQFGEVWMG--YYNNSTKVAVKTLKPGT----MSVQAFLE 57 Query: 62 VAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPG-VPTE 120 A L ++T +H +VRL+ V T RE + ++ E++ + K E G V Sbjct: 58 EANL--MKTLQHDKLVRLYAVVT-----REEPIYIITEYMAKGSLLDFLKSDEGGKVLLP 110 Query: 121 TIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY--SFQMALTS 178 + D Q+ G+ ++ +HRDL+ N+LV+ S K+ADFGLAR+ + A Sbjct: 111 KLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREG 170 Query: 179 VVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPL-FRGSSDVDQLGKILDVIGL 237 + + APE + + D+WS G + E+ + + G ++ D + + + Sbjct: 171 AKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRM 230 Query: 238 PGEEDWPRDV 247 P E+ P ++ Sbjct: 231 PRVENCPDEL 240 >3KRL-A nrPDB Length = 335 Score = 72.0 bits (175), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 58/216 (26%), Positives = 100/216 (46%), Gaps = 28/216 (12%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALK---RVRVQTGEEGMPLSTIREVAVLRHLETFEHPN 75 +G GA+GKV +A G LK ++ T + + E+ ++ HL +H N Sbjct: 54 LGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLG--QHEN 111 Query: 76 VVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPGV---------PTETI--K 123 +V L CT + ++ E+ DL +L + PG+ P E + + Sbjct: 112 IVNLLGACT-----HGGPVLVITEYCCYGDLLNFLRRKRPPGLEYSYNPSHNPEEQLSSR 166 Query: 124 DMMF---QLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY---SFQMALT 177 D++ Q+ +G+ FL S +HRD+ +N+L+T+ K+ DFGLAR S + Sbjct: 167 DLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKG 226 Query: 178 SVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMF 213 + + + + APE + Y D+WS G + E+F Sbjct: 227 NARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIF 262 >6E4F-A nrPDB Length = 290 Score = 72.0 bits (175), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 56/202 (27%), Positives = 102/202 (50%), Gaps = 19/202 (9%) Query: 16 VAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPN 75 + E+G G +G V + G VA+K ++ + E I E V+ +L H Sbjct: 36 LKELGTGQFGVVKYGK--WRGQYDVAIKMIKEGSMSED---EFIEEAKVMMNLS---HEK 87 Query: 76 VVRLFDVCTVSRTDRETKLTLVFEHVDQD-LTTYLDKVPEPGVPTETIKDMMFQLLRGLD 134 +V+L+ VCT R + ++ E++ L YL ++ T+ + +M + ++ Sbjct: 88 LVQLYGVCTKQRP-----IFIITEYMANGCLLNYLREMRHR-FQTQQLLEMCKDVCEAME 141 Query: 135 FLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLW---YRAPEVL 191 +L S + +HRDL +N LV G +K++DFGL+R Y TS V + + + PEVL Sbjct: 142 YLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSR-YVLDDEYTSSVGSKFPVRWSPPEVL 200 Query: 192 LQSSYATPVDLWSVGCIFAEMF 213 + S +++ D+W+ G + E++ Sbjct: 201 MYSKFSSKSDIWAFGVLMWEIY 222 >4EBW-A nrPDB Length = 304 Score = 71.6 bits (174), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 63/233 (27%), Positives = 114/233 (48%), Gaps = 19/233 (8%) Query: 19 IGEGAYGKVFKARDL--KNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNV 76 IGEG +G V + + +N VA+K + T + + ++E +R F+HP++ Sbjct: 46 IGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSD-SVREKFLQEALTMRQ---FDHPHI 101 Query: 77 VRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDF 135 V+L V T E + ++ E +L ++L +V + + ++ +QL L + Sbjct: 102 VKLIGVIT------ENPVWIIMELCTLGELRSFL-QVRKYSLDLASLILYAYQLSTALAY 154 Query: 136 LHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY---SFQMALTSVVVTLWYRAPEVLL 192 L S R VHRD+ +N+LV+S+ +KL DFGL+R ++ A + W APE + Sbjct: 155 LESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWM-APESIN 213 Query: 193 QSSYATPVDLWSVG-CIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWP 244 + + D+W G C++ + F+G + D +G+I + LP + P Sbjct: 214 FRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCP 266 >5GNK-A nrPDB Length = 297 Score = 71.6 bits (174), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 58/223 (26%), Positives = 100/223 (44%), Gaps = 32/223 (14%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRF---VALKRVRVQTGEEGMPLSTIREVAVLR 66 + +++ + +G GA+G V+K + G + VA+K +R T + + E V+ Sbjct: 18 ETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANK-EILDEAYVM- 75 Query: 67 HLETFEHPNVVRLFDVCTVSRTDRETKLT-------LVFEHVDQDLTTYLDKVPEPGVPT 119 + ++P+V RL +C S +L V EH D + YL Sbjct: 76 --ASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYL---------- 123 Query: 120 ETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSF---QMAL 176 + Q+ +G+++L R+VHRDL +N+LV + +K+ DFGLA++ + Sbjct: 124 ---LNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHA 180 Query: 177 TSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEM--FRRKP 217 V + + A E +L Y D+WS G E+ F KP Sbjct: 181 EGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKP 223 >6GQK-A nrPDB Length = 328 Score = 71.6 bits (174), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 61/217 (28%), Positives = 94/217 (43%), Gaps = 30/217 (13%) Query: 19 IGEGAYGKVFKARD---LKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPN 75 +G GA+GKV +A +K+ ++ + + + E+ VL +L H N Sbjct: 49 LGAGAFGKVVEATAQGLIKSDAAMTVAVKMLKPSAHSTEREALMSELKVLSYLGN--HEN 106 Query: 76 VVRLFDVCTVSRTDRETKLTLVFEH--VDQDLTTYLDK-----VPEPGVPTETIKDMM-- 126 +V L CT TLV DL +L + VP P + KD + Sbjct: 107 IVNLLGACT------HGGPTLVITEYCCYGDLLNFLRRKRDEFVPYKVAPEDLYKDFLTL 160 Query: 127 -------FQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY---SFQMAL 176 +Q+ +G+ FL S +HRDL +NIL+T K+ DFGLAR S + Sbjct: 161 EHLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGNITKICDFGLARDIKNDSNYVDK 220 Query: 177 TSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMF 213 + + + + APE + S Y D+WS G E+F Sbjct: 221 GNARLPVKWMAPESIFNSVYTFESDVWSYGIFLWELF 257 >3UIM-A nrPDB Length = 326 Score = 71.6 bits (174), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 69/236 (29%), Positives = 111/236 (47%), Gaps = 33/236 (13%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRV---RVQTGEEGMPLSTIREVAVLRHLETFEHPN 75 +G G +GKV+K R G VA+KR+ R Q GE L EV ++ H N Sbjct: 38 LGRGGFGKVYKGR--LADGTLVAVKRLKEERTQGGE----LQFQTEVEMI---SMAVHRN 88 Query: 76 VVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPGVPTETIKDMMFQL--LRG 132 ++RL C T+ LV+ ++ + + + L + PE P + K L RG Sbjct: 89 LLRLRGFCMTP-----TERLLVYPYMANGSVASCLRERPESQPPLDWPKRQRIALGSARG 143 Query: 133 LDFLHSH---RVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQ--MALTSVVVTLWYRA 187 L +LH H +++HRD+K NIL+ + + DFGLA++ ++ T+V T+ + A Sbjct: 144 LAYLHDHCDPKIIHRDVKAANILLDEEFEAVVGDFGLAKLMDYKDTHVTTAVRGTIGHIA 203 Query: 188 PEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDW 243 PE L + D++ G + E+ + F D+ +L DV+ L DW Sbjct: 204 PEYLSTGKSSEKTDVFGYGVMLLELITGQRAF----DLARLANDDDVMLL----DW 251 >2J0K-A nrPDB Length = 656 Score = 71.2 bits (173), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 62/233 (26%), Positives = 114/233 (48%), Gaps = 19/233 (8%) Query: 19 IGEGAYGKVFKARDL--KNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNV 76 IGEG +G V + + +N VA+K + T + + ++E +R F+HP++ Sbjct: 398 IGEGQFGDVHQGIYMSPENPAMAVAIKTCKNCTSD-SVREKFLQEALTMRQ---FDHPHI 453 Query: 77 VRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDF 135 V+L V T E + ++ E +L ++L +V + + ++ +QL L + Sbjct: 454 VKLIGVIT------ENPVWIIMELCTLGELRSFL-QVRKFSLDLASLILYAYQLSTALAY 506 Query: 136 LHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY---SFQMALTSVVVTLWYRAPEVLL 192 L S R VHRD+ +N+LV+++ +KL DFGL+R ++ A + W APE + Sbjct: 507 LESKRFVHRDIAARNVLVSATDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWM-APESIN 565 Query: 193 QSSYATPVDLWSVG-CIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWP 244 + + D+W G C++ + F+G + D +G+I + LP + P Sbjct: 566 FRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCP 618 >3V5Q-A nrPDB Length = 297 Score = 71.2 bits (173), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 65/231 (28%), Positives = 109/231 (47%), Gaps = 36/231 (15%) Query: 18 EIGEGAYGKVFKARDLK----NGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEH 73 E+GEGA+GKVF A VA+K ++ T RE +L +L+ H Sbjct: 22 ELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQ--REAELLTNLQ---H 76 Query: 74 PNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYL-----------DKVPEPGVPTET 121 ++V+ + VC L +VFE++ DL +L D P Sbjct: 77 EHIVKFYGVCGDG-----DPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELG 131 Query: 122 IKDMMF---QLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLAR-IYS---FQM 174 + M+ Q+ G+ +L S VHRDL +N LV ++ +K+ DFG++R +YS +++ Sbjct: 132 LSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRV 191 Query: 175 ALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFR--RKPLFRGSS 223 +++ W PE ++ + T D+WS G I E+F ++P F+ S+ Sbjct: 192 GGHTMLPIRWM-PPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSN 241 >2PMN-X nrPDB Length = 348 Score = 71.2 bits (173), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 59/218 (27%), Positives = 102/218 (46%), Gaps = 20/218 (9%) Query: 96 LVFEHVDQD----LTTY---LDKVPEPGVPTETIKDMMFQLLRGLDFLHSHR-VVHRDLK 147 +++E+++ D Y LDK +P + IK ++ +L ++H+ + + HRD+K Sbjct: 120 IIYEYMENDSILKFDEYFFVLDKNYTCFIPIQVIKCIIKSVLNSFSYIHNEKNICHRDVK 179 Query: 148 PQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLL-QSSY-ATPVDLWSV 205 P NIL+ +G++KL+DFG + Y + T + PE +SSY VD+WS+ Sbjct: 180 PSNILMDKNGRVKLSDFGESE-YMVDKKIKGSRGTYEFMPPEFFSNESSYNGAKVDIWSL 238 Query: 206 G-CIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEK 264 G C++ + P S V+ I ++P D +K + Sbjct: 239 GICLYVMFYNVVPFSLKISLVELFNNI-----RTKNIEYPLDRNHFLYPLTNKKSTCSNN 293 Query: 265 FVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQD 302 F+++ D D L L NPA+RI++ AL H + D Sbjct: 294 FLSNED---IDFLKLFLRKNPAERITSEDALKHEWLAD 328 >2PL0-A nrPDB Length = 289 Score = 71.2 bits (173), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 52/200 (26%), Positives = 96/200 (48%), Gaps = 17/200 (8%) Query: 16 VAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPN 75 V +G G +G+V+ NG VA+K ++ + P + + E +++ L+ H Sbjct: 28 VERLGAGQFGEVWMG--YYNGHTKVAVKSLKQGSMS---PDAFLAEANLMKQLQ---HQR 79 Query: 76 VVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQLLRGLD 134 +VRL+ V T + + ++ E+++ L +L + + DM Q+ G+ Sbjct: 80 LVRLYAVVT------QEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMA 133 Query: 135 FLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY--SFQMALTSVVVTLWYRAPEVLL 192 F+ +HRDL+ NILV+ + K+ADFGLAR+ + A + + APE + Sbjct: 134 FIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAIN 193 Query: 193 QSSYATPVDLWSVGCIFAEM 212 ++ D+WS G + E+ Sbjct: 194 YGTFTIKSDVWSFGILLTEI 213 >6BDL-A nrPDB Length = 347 Score = 70.9 bits (172), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 36/113 (31%), Positives = 56/113 (49%), Gaps = 3/113 (2%) Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAP 188 ++ +LHS +++RDLKP+N+++ G KL DFG A+ F + T Y AP Sbjct: 144 VVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAP 203 Query: 189 EVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKIL---DVIGLP 238 E++L + D WS+G + E+ P F G + IL D+I P Sbjct: 204 EIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFP 256 >5FM2-A nrPDB Length = 355 Score = 70.9 bits (172), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 63/222 (28%), Positives = 106/222 (47%), Gaps = 35/222 (15%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIRE-VAVLRHLETFEHPNVV 77 +GEG +GKV KA GR V V+ +E S +R+ ++ L+ HP+V+ Sbjct: 72 LGEGEFGKVVKATAFHLKGR-AGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVI 130 Query: 78 RLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPE--PGV--------------PTE 120 +L+ C+ ++ L L+ E+ L +L + + PG P E Sbjct: 131 KLYGACS-----QDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDE 185 Query: 121 ---TIKDMM---FQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLAR-IY--- 170 T+ D++ +Q+ +G+ +L ++VHRDL +NILV ++K++DFGL+R +Y Sbjct: 186 RALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEED 245 Query: 171 SFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEM 212 S+ + W A E L Y T D+WS G + E+ Sbjct: 246 SYVKRSQGRIPVKWM-AIESLFDHIYTTQSDVWSFGVLLWEI 286 >2JDO-A nrPDB Length = 342 Score = 70.9 bits (172), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 60/197 (30%), Positives = 98/197 (49%), Gaps = 14/197 (7%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLS-TIREVAVLRHLETFEHPNVV 77 +G+G +GKV R+ K GR+ A+K +R + ++ T+ E VL++ HP + Sbjct: 18 LGKGTFGKVILVRE-KATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTR---HPFLT 73 Query: 78 RLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFL 136 L DR L V E+ + +L +L + E E + +++ L++L Sbjct: 74 AL--KYAFQTHDR---LCFVMEYANGGELFFHLSR--ERVFTEERARFYGAEIVSALEYL 126 Query: 137 HSHRVVHRDLKPQNILVTSSGQIKLADFGLARI-YSFQMALTSVVVTLWYRAPEVLLQSS 195 HS VV+RD+K +N+++ G IK+ DFGL + S + + T Y APEVL + Sbjct: 127 HSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDND 186 Query: 196 YATPVDLWSVGCIFAEM 212 Y VD W +G + EM Sbjct: 187 YGRAVDWWGLGVVMYEM 203 >4E20-A nrPDB Length = 290 Score = 70.5 bits (171), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 56/206 (27%), Positives = 94/206 (45%), Gaps = 18/206 (8%) Query: 16 VAEIGEGAYGKV-FKARDLKNGG--RFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 + ++GEG +GKV D N G VA+K ++ G + + RE+ +LR T Sbjct: 13 IRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQ-LRSGWQREIEILR---TLY 68 Query: 73 HPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRG 132 H ++V+ C E + LV E+V L + D +P V + Q+ G Sbjct: 69 HEHIVKYKGCC---EDQGEKSVQLVMEYVP--LGSLRDYLPRHCVGLAQLLLFAQQICEG 123 Query: 133 LDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYS-----FQMALTSVVVTLWYRA 187 + +LH+ +HR L +N+L+ + +K+ DFGLA+ +++ WY A Sbjct: 124 MAYLHAQHYIHRALAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWY-A 182 Query: 188 PEVLLQSSYATPVDLWSVGCIFAEMF 213 PE L + + D+WS G E+ Sbjct: 183 PECLKECKFYYASDVWSFGVTLYELL 208 >5GRN-A nrPDB Length = 356 Score = 70.5 bits (171), Expect = 9e-13, Method: Compositional matrix adjust. Identities = 60/222 (27%), Positives = 101/222 (45%), Gaps = 30/222 (13%) Query: 19 IGEGAYGKVFK--ARDLKNGGRF--VALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHP 74 +G GA+GKV + A L VA+K ++ T + + E+ ++ HL H Sbjct: 54 LGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLK-PTARSSEKQALMSELKIMTHLGP--HL 110 Query: 75 NVVRLFDVCTVS-------------------RTDRETKLTLVFEHV-DQDLTTYLDKVPE 114 N+V L CT S +R++ L+ + + D ++ L Sbjct: 111 NIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHKKKSMLDSEVKNLLSDDNS 170 Query: 115 PGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY---S 171 G+ + +Q+ RG++FL S VHRDL +N+L+ +K+ DFGLAR S Sbjct: 171 EGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDS 230 Query: 172 FQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMF 213 ++ S + + + APE + + Y T D+WS G + E+F Sbjct: 231 NYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIF 272 >3HNG-A nrPDB Length = 360 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 37/99 (37%), Positives = 60/99 (60%), Gaps = 6/99 (6%) Query: 121 TIKDMM---FQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLAR-IYSF--QM 174 T++D++ FQ+ RG++FL S + +HRDL +NIL++ + +K+ DFGLAR IY + Sbjct: 197 TMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYV 256 Query: 175 ALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMF 213 + L + APE + Y+T D+WS G + E+F Sbjct: 257 RKGDTRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIF 295 >2QKW-B nrPDB Length = 321 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 57/201 (28%), Positives = 100/201 (49%), Gaps = 18/201 (8%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVR 78 IG G +GKV+K L++G + VALKR R +G+ L HP++V Sbjct: 47 IGHGVFGKVYKGV-LRDGAK-VALKR-RTPESSQGIEEFETEIET----LSFCRHPHLVS 99 Query: 79 LFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYL--DKVPEPGVPTETIKDMMFQLLRGLDF 135 L C D ++ L++++++ +L +L +P + E ++ RGL + Sbjct: 100 LIGFC-----DERNEMILIYKYMENGNLKRHLYGSDLPTMSMSWEQRLEICIGAARGLHY 154 Query: 136 LHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSF--QMALTSVVV-TLWYRAPEVLL 192 LH+ ++HRD+K NIL+ + K+ DFG+++ + Q L++VV TL Y PE + Sbjct: 155 LHTRAIIHRDVKSINILLDENFVPKITDFGISKKGTELDQTHLSTVVKGTLGYIDPEYFI 214 Query: 193 QSSYATPVDLWSVGCIFAEMF 213 + D++S G + E+ Sbjct: 215 KGRLTEKSDVYSFGVVLFEVL 235 >4Y83-A nrPDB Length = 332 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 79/285 (27%), Positives = 117/285 (41%), Gaps = 49/285 (17%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVR 78 I GA+GKV+ A+D+K R +A K + V + S + A RH N+ Sbjct: 81 IPRGAFGKVYLAQDIKTKKR-MACKLIPVDQFKP----SDVEIQACFRH------ENIAE 129 Query: 79 LFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTE-TIKDMMFQLLRGLDFLH 137 L+ T + L E + + L+K+ G E I + +L+GLDFLH Sbjct: 130 LYGAVLWGET-----VHLFMEAGEGG--SVLEKLESCGPMREFEIIWVTKHVLKGLDFLH 182 Query: 138 SHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMA-----LTSVVVTLWYRAPEVLL 192 S +V+H D+KP NI+ S+ + L DFGL S QM + T Y +PEV+L Sbjct: 183 SKKVIHHDIKPSNIVFMSTKAV-LVDFGL----SVQMTEDVYFPKDLRGTEIYMSPEVIL 237 Query: 193 QSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQ 252 ++T D++S+G M P P + +PR Sbjct: 238 CRGHSTKADIYSLGATLIHMQTGTP--------------------PWVKRYPRSAYPSYL 277 Query: 253 AFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSH 297 K A P+E D ++L+ L NP R A L H Sbjct: 278 YIIHKQAPPLEDIADDCSPGMRELIEASLERNPNHRPRAADLLKH 322 >4HVI-A nrPDB Length = 314 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 56/206 (27%), Positives = 95/206 (46%), Gaps = 17/206 (8%) Query: 16 VAEIGEGAYGKVFKARD---LKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 ++++G+G +G V R N G VA+K+++ ++ RE+ +L+ L Sbjct: 15 ISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQ--REIQILKAL---- 68 Query: 73 HPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRG 132 H + + + VS L LV E++ + + + Q+ +G Sbjct: 69 HSDFIVKYR--GVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKG 126 Query: 133 LDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSV-----VVTLWYRA 187 +++L S R VHRDL +NILV S +K+ADFGLA++ V WY A Sbjct: 127 MEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWY-A 185 Query: 188 PEVLLQSSYATPVDLWSVGCIFAEMF 213 PE L + ++ D+WS G + E+F Sbjct: 186 PESLSDNIFSRQSDVWSFGVVLYELF 211 >5DBX-A nrPDB Length = 328 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 85/311 (27%), Positives = 135/311 (43%), Gaps = 45/311 (14%) Query: 6 LCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVL 65 +CR YE IG GA V +A K VA+KR+ ++ + M ++E+ + Sbjct: 8 ICR--DAYELQEVIGSGATA-VVQAALCKPRQERVAIKRINLEKCQTSMD-ELLKEIQAM 63 Query: 66 RHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ----DLTTYLDKVPE--PGVPT 119 HPNVV + V + +L LV + + D+ Y+ E GV Sbjct: 64 SQCS---HPNVVTYYTSFVV-----KDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLE 115 Query: 120 ETI-KDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALT- 177 E I ++ ++L GLD+LH + +HRDLK NIL+ G +++ADFG++ + +T Sbjct: 116 EAIIATILKEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTR 175 Query: 178 -----SVVVTLWYRAPEVLLQ-SSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKI 231 V T + APEV+ Q Y D+WS G E L G++ + Sbjct: 176 NKVRKDFVGTPCWMAPEVMEQVRGYDFKADMWSFGITAIE------LATGAAPYHKYPP- 228 Query: 232 LDVIGLPGEEDWPR-DVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRIS 290 + V+ L + D P + + + K + K LL CL +P+KR + Sbjct: 229 MKVLMLTLQNDPPTLETGVEDKEMMKKYGKSFRK-----------LLSLCLQKDPSKRPT 277 Query: 291 AYSALSHPYFQ 301 A L +FQ Sbjct: 278 AAELLKCKFFQ 288 >4Y93-A nrPDB Length = 446 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 54/202 (26%), Positives = 101/202 (50%), Gaps = 19/202 (9%) Query: 16 VAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPN 75 + E+G G +G V + G VA+K ++ + E I E V+ +L H Sbjct: 193 LKELGTGQFGVVKYGK--WRGQYDVAIKMIKEGSMSED---EFIEEAKVMMNLS---HEK 244 Query: 76 VVRLFDVCTVSRTDRETKLTLVFEHVDQD-LTTYLDKVPEPGVPTETIKDMMFQLLRGLD 134 +V+L+ VCT R + ++ E++ L YL ++ T+ + +M + ++ Sbjct: 245 LVQLYGVCTKQRP-----IFIITEYMANGCLLNYLREMRH-RFQTQQLLEMCKDVCEAME 298 Query: 135 FLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLW---YRAPEVL 191 +L S + +HRDL +N LV G +K++DFG+ R Y TS + + + +PEVL Sbjct: 299 YLESKQFLHRDLAARNCLVNDQGVVKVSDFGMTR-YVLDDEYTSSTGSKFPVKWASPEVL 357 Query: 192 LQSSYATPVDLWSVGCIFAEMF 213 + S +++ D+W+ G + E++ Sbjct: 358 MYSKFSSKSDIWAFGVLMWEIY 379 >5HI2-A nrPDB Length = 283 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 56/233 (24%), Positives = 108/233 (46%), Gaps = 27/233 (11%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLE 69 D Q IG G++G V+K G++ V++ T ++ EV VLR Sbjct: 19 DGQITVGQRIGSGSFGTVYK-------GKWHGDVAVKMLTPQQLQAFKN--EVGVLR--- 66 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQL 129 H N++ T + +L +V + + + E + + D+ Q Sbjct: 67 KTRHVNILLFMGYST------KPQLAIVTQWCEGSSLYHHLHASETKFEMKKLIDIARQT 120 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARI---YSFQMALTSVVVTLWYR 186 RG+D+LH+ ++HRDLK NI + +K+ DFGLA + +S + ++ + Sbjct: 121 ARGMDYLHAKSIIHRDLKSNNIFLHEDNTVKIGDFGLATVKSRWSGSHQFEQLSGSILWM 180 Query: 187 APEVL-LQSS--YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIG 236 APEV+ +Q S Y+ D+++ G + E+ + + S+++ +I++++G Sbjct: 181 APEVIRMQDSNPYSFQSDVYAFGIVLYELMTGQLPY---SNINNRDQIIEMVG 230 >5MJB-A nrPDB Length = 305 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 62/237 (26%), Positives = 108/237 (45%), Gaps = 22/237 (9%) Query: 19 IGEGAYGKVFKARDLKNGGR--FVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNV 76 IG G +G+V+K R G R +VA+K ++ E+ + E +++ F+H N+ Sbjct: 34 IGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEK-QRRDFLSEASIMGQ---FDHRNI 89 Query: 77 VRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFL 136 +RL V T SR + ++ E ++ + + + M+ + G+ +L Sbjct: 90 IRLEGVVTKSRP-----VMIITEFMENCALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYL 144 Query: 137 HSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY-------SFQMALTSVVVTLWYRAPE 189 VHRDL +NILV S+ K++DFGL+R ++ +L + W APE Sbjct: 145 SEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRW-TAPE 203 Query: 190 VLLQSSYATPVDLWSVGCIFAEM--FRRKPLFRGSSDVDQLGKILDVIGLPGEEDWP 244 + + + D+WS G + E+ F +P + S+ D + I LP D P Sbjct: 204 AIAYRKFTSASDVWSYGIVMWEVMSFGERP-YWDMSNQDVINAIEQDYRLPPPMDCP 259 >4R7H-A nrPDB Length = 343 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 59/223 (26%), Positives = 100/223 (44%), Gaps = 35/223 (15%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALK---RVRVQTGEEGMPLSTIREVAVLRHLETFEHPN 75 +G GA+GKV +A G LK ++ T + + E+ ++ HL +H N Sbjct: 58 LGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLG--QHEN 115 Query: 76 VVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPE--------PGVPTET----- 121 +V L CT + ++ E+ DL +L + E PG E Sbjct: 116 IVNLLGACT-----HGGPVLVITEYCTYGDLLNFLRRKAEAMLGPSLSPGQDPEGLDKED 170 Query: 122 -----IKDMMF---QLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY--- 170 ++D++ Q+ +G+ FL S +HRD+ +N+L+T+ K+ DFGLAR Sbjct: 171 GRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMND 230 Query: 171 SFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMF 213 S + + + + + APE + S Y D+WS G + E+F Sbjct: 231 SNYIVKGNARLPVKWMAPESIFDSVYTVQSDVWSYGILLWEIF 273 >6ED6-A nrPDB Length = 415 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 71/237 (29%), Positives = 104/237 (43%), Gaps = 20/237 (8%) Query: 5 GLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAV 64 GL + Y+ V IG GA+G+V R K + A+K + + E + S Sbjct: 82 GLQMKAEDYDVVKVIGRGAFGEVQLVRH-KASQKVYAMKLL---SKFEMIKRSDSAFFWE 137 Query: 65 LRHLETFEH-PNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPGVPTETI 122 R + F + P VV+LF R L +V E++ DL + VP + Sbjct: 138 ERDIMAFANSPWVVQLFYAFQDDRY-----LYMVMEYMPGGDLVNLMSNY---DVPEKWA 189 Query: 123 KDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFG--LARIYSFQMALTSVV 180 K +++ LD +HS ++HRD+KP N+L+ G +KLADFG + + + + V Sbjct: 190 KFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAV 249 Query: 181 VTLWYRAPEVLLQSS----YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILD 233 T Y +PEVL Y D WSVG EM F S V KI+D Sbjct: 250 GTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMD 306 >3BBT-B nrPDB Length = 328 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 57/217 (26%), Positives = 95/217 (43%), Gaps = 32/217 (14%) Query: 16 VAEIGEGAYGKVFKARDLKNGGRF---VALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 V +G GA+G V+K + G VA+K + TG P + + + + + + Sbjct: 20 VKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTG----PKANVEFMDEALIMASMD 75 Query: 73 HPNVVRLFDVCTVSRTDRETKLT-------LVFEHVDQDLTTYLDKVPEPGVPTETIKDM 125 HP++VRL VC T+L V EH D + ++ + + Sbjct: 76 HPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDN-------------IGSQLLLNW 122 Query: 126 MFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSF---QMALTSVVVT 182 Q+ +G+ +L R+VHRDL +N+LV S +K+ DFGLAR+ + + Sbjct: 123 CVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMP 182 Query: 183 LWYRAPEVLLQSSYATPVDLWSVGCIFAEM--FRRKP 217 + + A E + + D+WS G E+ F KP Sbjct: 183 IKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKP 219 >5TQX-A nrPDB Length = 655 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 62/209 (29%), Positives = 97/209 (46%), Gaps = 20/209 (9%) Query: 13 YECVAEIGEGAYGKV--FKAR--DLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHL 68 +E +G G +G V ++ R DLK +A+K R++ + E+ +++ L Sbjct: 10 WEMRERLGTGGFGNVCLYQHRELDLK-----IAIKSCRLELSTKNRE-RWCHEIQIMKKL 63 Query: 69 ETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEP--GVPTETIKDM 125 H NVV+ DV L E+ DL L+K PE G+ I + Sbjct: 64 N---HANVVKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNK-PENCCGLKESQILSL 119 Query: 126 MFQLLRGLDFLHSHRVVHRDLKPQNILVTS-SGQI--KLADFGLARIYSFQMALTSVVVT 182 + + G+ +LH ++++HRDLKP+NI++ G+I K+ D G A+ T V T Sbjct: 120 LSDIGSGIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGELCTEFVGT 179 Query: 183 LWYRAPEVLLQSSYATPVDLWSVGCIFAE 211 L Y APE+ Y VD WS G + E Sbjct: 180 LQYLAPELFENKPYTATVDYWSFGTMVFE 208 >5HLW-A nrPDB Length = 299 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 61/213 (28%), Positives = 99/213 (46%), Gaps = 33/213 (15%) Query: 19 IGEGAYGKVFKARDLKNGGRFV-----ALKRVRVQTGEEGMPLSTIREVAVLRHLETFEH 73 IG G +G V+ L N G+ + +L R+ GE L+ E +++ F H Sbjct: 28 IGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRI-TDIGEVSQFLT---EGIIMK---DFSH 80 Query: 74 PNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYL-DKVPEPGVPTETIKDMM---FQ 128 PNV+ L +C S E +V ++ DL ++ ++ P T+KD++ Q Sbjct: 81 PNVLSLLGICLRS----EGSPLVVLPYMKHGDLRNFIRNETHNP-----TVKDLIGFGLQ 131 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLAR------IYSFQMALTSVVVT 182 + +G+ +L S + VHRDL +N ++ +K+ADFGLAR YS + + Sbjct: 132 VAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMHDKEYYSVHNKTGAKLPV 191 Query: 183 LWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRR 215 W A E L + T D+WS G + E+ R Sbjct: 192 KW-MALESLQTQKFTTKSDVWSFGVLLWELMTR 223 >3C1X-A nrPDB Length = 373 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 60/212 (28%), Positives = 101/212 (47%), Gaps = 31/212 (14%) Query: 19 IGEGAYGKVFKARDLKNGGRFV-----ALKRVRVQTGEEGMPLSTIREVAVLRHLETFEH 73 IG G +G V+ L N G+ + +L R+ GE +S ++ ++ F H Sbjct: 97 IGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRI-TDIGE----VSQFLTEGII--MKDFSH 149 Query: 74 PNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYL-DKVPEPGVPTETIKDMM---FQ 128 PNV+ L +C S E +V ++ DL ++ ++ P T+KD++ Q Sbjct: 150 PNVLSLLGICLRS----EGSPLVVLPYMKHGDLRNFIRNETHNP-----TVKDLIGFGLQ 200 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLAR-IYSFQM----ALTSVVVTL 183 + +G+ FL S + VHRDL +N ++ +K+ADFGLAR +Y + T + + Sbjct: 201 VAKGMKFLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEFDSVHNKTGAKLPV 260 Query: 184 WYRAPEVLLQSSYATPVDLWSVGCIFAEMFRR 215 + A E L + T D+WS G + E+ R Sbjct: 261 KWMALESLQTQKFTTKSDVWSFGVLLWELMTR 292 >3PP0-A nrPDB Length = 338 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 57/213 (26%), Positives = 98/213 (46%), Gaps = 24/213 (11%) Query: 16 VAEIGEGAYGKVFKARDLKNGGRF---VALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 V +G GA+G V+K + +G VA+K +R T + + E V+ + + Sbjct: 22 VKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANK-EILDEAYVMAGVGS-- 78 Query: 73 HPNVVRLFDVCTVSRTDRETKLT---LVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQL 129 P V RL +C S T+L + +HV ++ + ++ + + Q+ Sbjct: 79 -PYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGR---------LGSQDLLNWCMQI 128 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSF---QMALTSVVVTLWYR 186 +G+ +L R+VHRDL +N+LV S +K+ DFGLAR+ + V + + Sbjct: 129 AKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWM 188 Query: 187 APEVLLQSSYATPVDLWSVGCIFAEM--FRRKP 217 A E +L+ + D+WS G E+ F KP Sbjct: 189 ALESILRRRFTHQSDVWSYGVTVWELMTFGAKP 221 >4F9B-A nrPDB Length = 361 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 90/364 (24%), Positives = 140/364 (38%), Gaps = 90/364 (24%) Query: 13 YECVAEIGEGAYGKVFKARDLKNGGRF--VALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 YE V ++ VFK D G F V L ++Q G E E L+HL Sbjct: 13 YEAVPQLS-----NVFKIEDKIGEGTFSSVYLATAQLQVGPE--------EKIALKHLIP 59 Query: 71 FEHP-NVVRLFDVCTVSR-TDRETKLTLVFEHVDQ--------DLTTYLDKVPEPGVPTE 120 HP + TV+ D + F D + ++LD + + + Sbjct: 60 TSHPIRIAAELQCLTVAGGQDNVMGVKYCFRKNDHVVIAMPYLEHESFLDILN--SLSFQ 117 Query: 121 TIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSS-GQIKLADFGLAR----------- 168 +++ M L + L +H +VHRD+KP N L + L DFGLA+ Sbjct: 118 EVREYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLK 177 Query: 169 ------------------IYSFQMALTSVVVTLWYRAPEVLLQS-SYATPVDLWSVGCIF 209 S + + T +RAPEVL + + T +D+WS G IF Sbjct: 178 FVQSEAQQERCSQNKCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIF 237 Query: 210 AEMFR-RKPLFRGSSDVDQLGKILDVIG----LPGEEDWPRDV----ALPRQAFHS---- 256 + R P ++ S D+ L +I+ + G + + + + + +P Q Sbjct: 238 LSLLSGRYPFYKASDDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCER 297 Query: 257 ----KSAQPIEKFVTDIDELGKDL-------------LLKCLTFNPAKRISAYSALSHPY 299 S+ P K +DI +L L K L NPA RI+A AL HP+ Sbjct: 298 LRGMDSSTP--KLTSDIQGHATNLEGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPF 355 Query: 300 FQDL 303 F+D+ Sbjct: 356 FKDM 359 >3BEA-A nrPDB Length = 333 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 56/214 (26%), Positives = 98/214 (45%), Gaps = 26/214 (12%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALK---RVRVQTGEEGMPLSTIREVAVLRHLETFEHPN 75 +G GA+GKV +A G LK ++ T + + E+ ++ HL +H N Sbjct: 54 LGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLG--QHEN 111 Query: 76 VVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKV-------PEPGVPTETI--KDM 125 +V L CT + ++ E+ DL +L + P + T+ +D+ Sbjct: 112 IVNLLGACT-----HGGPVLVITEYCCYGDLLNFLRRKSRVLETDPAFAIANSTLSTRDL 166 Query: 126 MF---QLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY---SFQMALTSV 179 + Q+ +G+ FL S +HRD+ +N+L+T+ K+ DFGLAR S + + Sbjct: 167 LHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNA 226 Query: 180 VVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMF 213 + + + APE + Y D+WS G + E+F Sbjct: 227 RLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIF 260 >6F3F-A nrPDB Length = 455 Score = 68.6 bits (166), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 54/198 (27%), Positives = 96/198 (48%), Gaps = 17/198 (8%) Query: 18 EIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVV 77 ++G+G +G+V+ NG VA+K ++ T P + ++E V++ L H +V Sbjct: 194 KLGQGCFGEVWMG--TWNGTTRVAIKTLKPGTMS---PEAFLQEAQVMKKLR---HEKLV 245 Query: 78 RLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFL 136 +L+ V + E + +V E++++ L +L + + DM Q+ G+ ++ Sbjct: 246 QLYAVVS------EEPIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYV 299 Query: 137 HSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY--SFQMALTSVVVTLWYRAPEVLLQS 194 VHRDL+ NILV + K+ADFGLAR+ + A + + APE L Sbjct: 300 ERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYG 359 Query: 195 SYATPVDLWSVGCIFAEM 212 + D+WS G + E+ Sbjct: 360 RFTIKSDVWSFGILLTEL 377 >6O8B-A nrPDB Length = 665 Score = 68.2 bits (165), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 63/228 (27%), Positives = 96/228 (42%), Gaps = 36/228 (15%) Query: 4 DGLCRADQQYECVAE--IGEGAYGKVFKARDLKNGGRFVA--------LKRVRVQTGEEG 53 DG+C++ + + +G+GA VF+ R K G F L+ V VQ Sbjct: 6 DGICQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ----- 60 Query: 54 MPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVP 113 +RE VL+ L H N+V+LF + T R L + F T + Sbjct: 61 -----MREFEVLKKLN---HKNIVKLFAI-EEETTTRHKVLIMEFCPCGSLYTVLEEPSN 111 Query: 114 EPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNIL--VTSSGQ--IKLADFGLARI 169 G+P ++ ++ G++ L + +VHR++KP NI+ + GQ KL DFG AR Sbjct: 112 AYGLPESEFLIVLRDVVGGMNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARE 171 Query: 170 YSFQMALTSVVVTLWYRAPEVL--------LQSSYATPVDLWSVGCIF 209 + T Y P++ Q Y VDLWS+G F Sbjct: 172 LEDDEQFVELYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTF 219 >5U6C-A nrPDB Length = 315 Score = 68.2 bits (165), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 55/209 (26%), Positives = 98/209 (46%), Gaps = 17/209 (8%) Query: 19 IGEGAYGKVFKARDLKNGGRF--VALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNV 76 +GEG +G V + + G VA+K +++ + + E A ++ F HPNV Sbjct: 44 LGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMK---DFSHPNV 100 Query: 77 VRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYL-----DKVPEPGVPTETIKDMMFQLL 130 +RL VC + K ++ + DL TYL + P+ +P +T+ M + Sbjct: 101 MRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKH-IPLQTLLKFMVDIA 159 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLA-RIYS---FQMALTSVVVTLWYR 186 G+++L + +HRDL +N ++ + +ADFGL+ +IYS ++ + + W Sbjct: 160 LGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWI- 218 Query: 187 APEVLLQSSYATPVDLWSVGCIFAEMFRR 215 A E L Y + D+W+ G E+ R Sbjct: 219 AIESLADRVYTSKSDVWAFGVTMWEIATR 247 >6E9W-A nrPDB Length = 443 Score = 68.2 bits (165), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 69/231 (29%), Positives = 103/231 (44%), Gaps = 20/231 (8%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 + YE V IG GA+G+V R K+ + A+K + + E + S R + Sbjct: 102 EDYEVVKVIGRGAFGEVQLVRH-KSTRKVYAMK---LLSKFEMIKRSDSAFFWEERDIMA 157 Query: 71 FEH-PNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPGVPTETIKDMMFQ 128 F + P VV+LF R L +V E++ DL + VP + + + Sbjct: 158 FANSPWVVQLFYAFQDDRY-----LYMVMEYMPGGDLVNLMSNY---DVPEKWARFYTAE 209 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQ--MALTSVVVTLWYR 186 ++ LD +HS +HRD+KP N+L+ SG +KLADFG + + + + V T Y Sbjct: 210 VVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYI 269 Query: 187 APEVLLQSS----YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILD 233 +PEVL Y D WSVG EM F S V KI++ Sbjct: 270 SPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMN 320 >4D2V-A nrPDB Length = 356 Score = 68.2 bits (165), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 72/296 (24%), Positives = 125/296 (42%), Gaps = 51/296 (17%) Query: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 YE IG G + KV A + G VA+K + T +P R + L+ Sbjct: 31 YELHETIGTGGFAKVKLACHILTG-EMVAIKIMDKNTLGSDLP----RIKTEIEALKNLR 85 Query: 73 HPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPGVPTETIKDMMFQLLR 131 H ++ +L+ V + K+ +V E+ +L Y+ + + + E + + Q++ Sbjct: 86 HQHICQLYHVLETA-----NKIFMVLEYCPGGELFDYI--ISQDRLSEEETRVVFRQIVS 138 Query: 132 GLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLA------RIYSFQMALTSVVVTLWY 185 + ++HS HRDLKP+N+L ++KL DFGL + Y Q ++ Y Sbjct: 139 AVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQACCGALA----Y 194 Query: 186 RAPEVLLQSSY-ATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWP 244 APE++ SY + D+WS+G + + F + + KI+ G+ D P Sbjct: 195 AAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDTAAALVAKIMR-----GKYDVP 249 Query: 245 RDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 + ++ P LL + L +P KRIS + L+HP+ Sbjct: 250 KWLS-PSSIL---------------------LLQQMLQVDPKKRISMKNLLNHPWI 283 >4JLC-A nrPDB Length = 657 Score = 68.2 bits (165), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 62/211 (29%), Positives = 89/211 (42%), Gaps = 34/211 (16%) Query: 19 IGEGAYGKVFKARDLKNGGRFVA--------LKRVRVQTGEEGMPLSTIREVAVLRHLET 70 +G+GA VF+ R K G + L+ V VQ +RE VL+ L Sbjct: 16 LGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQ----------MREFEVLKKLN- 64 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130 H N+V+LF + T R L + F T + G+P ++ ++ Sbjct: 65 --HKNIVKLFAI-EEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVV 121 Query: 131 RGLDFLHSHRVVHRDLKPQNIL--VTSSGQ--IKLADFGLARIYSFQMALTSVVVTLWYR 186 G++ L + +VHRD+KP NI+ + GQ KL DFG AR S+ T Y Sbjct: 122 GGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYL 181 Query: 187 APEVL--------LQSSYATPVDLWSVGCIF 209 P++ Q Y VDLWSVG F Sbjct: 182 HPDMYERAVLRKDHQKKYGATVDLWSVGVTF 212 >2HK5-A nrPDB Length = 270 Score = 68.2 bits (165), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 63/250 (25%), Positives = 112/250 (44%), Gaps = 18/250 (7%) Query: 2 EKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIRE 61 EKD + + ++G G +G+V+ A K+ +V V+T + G +S Sbjct: 6 EKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKH-------TKVAVKTMKPG-SMSVEAF 57 Query: 62 VAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTET 121 +A ++T +H +V+L V T +E + L +L P Sbjct: 58 LAEANVMKTLQHDKLVKLHAVVT-----KEPIYIITEFMAKGSLLDFLKSDEGSKQPLPK 112 Query: 122 IKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY--SFQMALTSV 179 + D Q+ G+ F+ +HRDL+ NILV++S K+ADFGLAR+ + A Sbjct: 113 LIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGA 172 Query: 180 VVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEM--FRRKPLFRGSSDVDQLGKILDVIGL 237 + + APE + S+ D+WS G + E+ + R P + G S+ + + + + Sbjct: 173 KFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIP-YPGMSNPEVIRALERGYRM 231 Query: 238 PGEEDWPRDV 247 P E+ P ++ Sbjct: 232 PRPENCPEEL 241 >2H8H-A nrPDB Length = 535 Score = 68.2 bits (165), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 54/198 (27%), Positives = 95/198 (47%), Gaps = 17/198 (8%) Query: 18 EIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVV 77 ++G+G +G+V+ NG VA+K ++ T P + ++E V++ L H +V Sbjct: 274 KLGQGCFGEVWMG--TWNGTTRVAIKTLKPGTMS---PEAFLQEAQVMKKLR---HEKLV 325 Query: 78 RLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFL 136 +L+ V + E + +V E++ + L +L + + DM Q+ G+ ++ Sbjct: 326 QLYAVVS------EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYV 379 Query: 137 HSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY--SFQMALTSVVVTLWYRAPEVLLQS 194 VHRDL+ NILV + K+ADFGLAR+ + A + + APE L Sbjct: 380 ERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYG 439 Query: 195 SYATPVDLWSVGCIFAEM 212 + D+WS G + E+ Sbjct: 440 RFTIKSDVWSFGILLTEL 457 >3MV5-A nrPDB Length = 342 Score = 67.8 bits (164), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 61/209 (29%), Positives = 102/209 (48%), Gaps = 21/209 (10%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVL----R 66 ++E + +G+G +GKV ++ K GR+ A+K ++ + + EVA R Sbjct: 10 NEFEYLKLLGKGTFGKVILVKE-KATGRYYAMKILKKEV------IVAKDEVAHTLTENR 62 Query: 67 HLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDM 125 L+ HP + L + DR L V E+ + +L +L + E + + Sbjct: 63 VLQNSRHPFLTAL--KYSFQTHDR---LCFVMEYANGGELFFHLSR--ERVFSEDRARFY 115 Query: 126 MFQLLRGLDFLHSHR-VVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMA-LTSVVVTL 183 +++ LD+LHS + VV+RDLK +N+++ G IK+ DFGL + A + + T Sbjct: 116 GAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTP 175 Query: 184 WYRAPEVLLQSSYATPVDLWSVGCIFAEM 212 Y APEVL + Y VD W +G + EM Sbjct: 176 EYLAPEVLEDNDYGRAVDWWGLGVVMYEM 204 >5IKW-A nrPDB Length = 310 Score = 67.8 bits (164), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 57/211 (27%), Positives = 96/211 (45%), Gaps = 25/211 (11%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTI--REVAVLRHLETFEHPNV 76 + EG + VF R +GG ALKR+ V MP + RE+ +++ L H N+ Sbjct: 22 LAEGGFSTVFLVR--THGGIRCALKRMYVNN----MPDLNVCKREITIMKELSG--HKNI 73 Query: 77 VRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQLLRGLDF 135 V D S +D ++ ++ E+ + ++K + G + + + Sbjct: 74 VGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVAR 133 Query: 136 LHSHR--VVHRDLKPQNILVTSSGQIKLADFGLA--RIYSFQMALTSVV-------VTLW 184 LH + ++HRDLK +NIL+ G L DFG A + + Q +VV TL Sbjct: 134 LHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLS 193 Query: 185 YRAPEVLL---QSSYATPVDLWSVGCIFAEM 212 YRAPE++ T D+W++GC+ ++ Sbjct: 194 YRAPEMINLYGGKPITTKADIWALGCLLYKL 224 >3DAK-A nrPDB Length = 290 Score = 67.8 bits (164), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 78/304 (25%), Positives = 133/304 (43%), Gaps = 43/304 (14%) Query: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 YE IG GA V +A VA+KR+ ++ + M ++E+ + Sbjct: 12 YELQEVIGSGATA-VVQAAYCAPKKEKVAIKRINLEKCQTSMD-ELLKEIQAMSQCH--- 66 Query: 73 HPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ----DLTTYLDKVPE--PGVPTE-TIKDM 125 HPN+V + V + +L LV + + D+ ++ E GV E TI + Sbjct: 67 HPNIVSYYTSFVV-----KDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATI 121 Query: 126 MFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALT------SV 179 + ++L GL++LH + +HRD+K NIL+ G +++ADFG++ + +T + Sbjct: 122 LREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTF 181 Query: 180 VVTLWYRAPEVLLQ-SSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLP 238 V T + APEV+ Q Y D+WS G E L G++ + + V+ L Sbjct: 182 VGTPCWMAPEVMEQVRGYDFKADIWSFGITAIE------LATGAAPYHKYPP-MKVLMLT 234 Query: 239 GEEDWPR-DVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSH 297 + D P + + + K + K ++ CL +P KR +A L H Sbjct: 235 LQNDPPSLETGVQDKEMLKKYGKSFRKMIS-----------LCLQKDPEKRPTAAELLRH 283 Query: 298 PYFQ 301 +FQ Sbjct: 284 KFFQ 287 >3PPZ-A nrPDB Length = 309 Score = 67.8 bits (164), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 60/200 (30%), Positives = 98/200 (49%), Gaps = 16/200 (8%) Query: 18 EIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVV 77 +IG G++G V +A + G VA+K + Q +REVA+++ L HPN+V Sbjct: 44 KIGAGSFGTVHRA---EWHGSDVAVKILMEQDFHAERVNEFLREVAIMKRLR---HPNIV 97 Query: 78 RLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIK-DMMFQLLRGLDF 135 T + L++V E++ + L L K E + M + + +G+++ Sbjct: 98 LFMGAVT-----QPPNLSIVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAKGMNY 152 Query: 136 LHSHR--VVHRDLKPQNILVTSSGQIKLADFGLARI-YSFQMALTSVVVTLWYRAPEVLL 192 LH+ +VHRDLK N+LV +K+ DFGL+R+ S ++ S T + APEVL Sbjct: 153 LHNRNPPIVHRDLKSPNLLVDKKYTVKVCDFGLSRLKASTFLSSKSAAGTPEWMAPEVLR 212 Query: 193 QSSYATPVDLWSVGCIFAEM 212 D++S G I E+ Sbjct: 213 DEPSNEKSDVYSFGVILWEL 232 >5TOS-A nrPDB Length = 395 Score = 67.8 bits (164), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 68/226 (30%), Positives = 108/226 (47%), Gaps = 30/226 (13%) Query: 9 ADQQYECVAEIGEGAYGKVFKA-------RDLKNG-GRFVALKRVRVQTGEEGMPLSTIR 60 A + + + IGEG +G VFK K G G +A+K++ Q G +G R Sbjct: 63 ATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLN-QEGFQGH-----R 116 Query: 61 E-VAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVP---EP 115 E + + +L HPN+V+L C + E +L LV+E + + L +L + +P Sbjct: 117 EWLTEINYLGQLSHPNLVKLIGYCL----EDEHRL-LVYEFMQKGSLENHLFRRGAYFKP 171 Query: 116 GVPTETIKDMMFQLLRGLDFLHSH--RVVHRDLKPQNILVTSSGQIKLADFGLAR---IY 170 +P ++ +GL FLHS +V++RD+K NIL+ + KL+DFGLAR + Sbjct: 172 -LPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMG 230 Query: 171 SFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRK 216 T V+ T Y APE + D++S G + E+ K Sbjct: 231 DLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGK 276 >5KCV-A nrPDB Length = 460 Score = 67.4 bits (163), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 61/209 (29%), Positives = 102/209 (48%), Gaps = 21/209 (10%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVL----R 66 ++E + +G+G +GKV ++ K GR+ A+K ++ + + EVA R Sbjct: 162 NEFEYLKLLGKGTFGKVILVKE-KATGRYYAMKILKKEV------IVAKDEVAHTLTENR 214 Query: 67 HLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDM 125 L+ HP + L + DR L V E+ + +L +L + E + + Sbjct: 215 VLQNSRHPFLTAL--KYSFQTHDR---LCFVMEYANGGELFFHLSR--ERVFSEDRARFY 267 Query: 126 MFQLLRGLDFLHSHR-VVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMA-LTSVVVTL 183 +++ LD+LHS + VV+RDLK +N+++ G IK+ DFGL + A + + T Sbjct: 268 GAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTP 327 Query: 184 WYRAPEVLLQSSYATPVDLWSVGCIFAEM 212 Y APEVL + Y VD W +G + EM Sbjct: 328 EYLAPEVLEDNDYGRAVDWWGLGVVMYEM 356 >5X5O-A nrPDB Length = 310 Score = 67.4 bits (163), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 46/209 (22%), Positives = 97/209 (46%), Gaps = 30/209 (14%) Query: 20 GEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRL 79 G G++G V++A+ + K ++++ +E +L L H N+++ Sbjct: 24 GGGSFGSVYRAKWISQDKEVAVKKLLKIE-----------KEAEILSVLS---HRNIIQF 69 Query: 80 FDVC----TVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDF 135 + V L ++++++ + + +D + I + +G+ + Sbjct: 70 YGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMD--------MDHIMTWATDVAKGMHY 121 Query: 136 LHSH---RVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLL 192 LH +V+HRDLK +N+++ + G +K+ DFG +R ++ + S+V T + APEV+ Sbjct: 122 LHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHM-SLVGTFPWMAPEVIQ 180 Query: 193 QSSYATPVDLWSVGCIFAEMFRRKPLFRG 221 + D +S G + EM R+ F+G Sbjct: 181 SLPVSETCDTYSYGVVLWEMLTREVPFKG 209 >1AD5-A nrPDB Length = 438 Score = 67.4 bits (163), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 62/248 (25%), Positives = 110/248 (44%), Gaps = 24/248 (9%) Query: 2 EKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIRE 61 EKD + + ++G G +G+V+ A K+ +V V+T + G +S Sbjct: 173 EKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKH-------TKVAVKTMKPG-SMSVEAF 224 Query: 62 VAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTET 121 +A ++T +H +V+L V T +E + L +L P Sbjct: 225 LAEANVMKTLQHDKLVKLHAVVT-----KEPIYIITEFMAKGSLLDFLKSDEGSKQPLPK 279 Query: 122 IKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVV 181 + D Q+ G+ F+ +HRDL+ NILV++S K+ADFGLAR+ Sbjct: 280 LIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARV--------GAKF 331 Query: 182 TLWYRAPEVLLQSSYATPVDLWSVGCIFAEM--FRRKPLFRGSSDVDQLGKILDVIGLPG 239 + + APE + S+ D+WS G + E+ + R P + G S+ + + + +P Sbjct: 332 PIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIP-YPGMSNPEVIRALERGYRMPR 390 Query: 240 EEDWPRDV 247 E+ P ++ Sbjct: 391 PENCPEEL 398 >4EUU-A nrPDB Length = 319 Score = 67.4 bits (163), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 61/211 (28%), Positives = 89/211 (42%), Gaps = 34/211 (16%) Query: 19 IGEGAYGKVFKARDLKNGGRFVA--------LKRVRVQTGEEGMPLSTIREVAVLRHLET 70 +G+GA VF+ R K G F L+ V VQ +RE VL+ L Sbjct: 17 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ----------MREFEVLKKLN- 65 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130 H N+V+LF + T R L + F T + G+P ++ ++ Sbjct: 66 --HKNIVKLFAI-EEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVV 122 Query: 131 RGLDFLHSHRVVHRDLKPQNIL--VTSSGQ--IKLADFGLARIYSFQMALTSVVVTLWYR 186 G++ L + +VHR++KP NI+ + GQ KL DFG AR S+ T Y Sbjct: 123 GGMNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYL 182 Query: 187 APEVL--------LQSSYATPVDLWSVGCIF 209 P++ Q Y VDLWS+G F Sbjct: 183 HPDMYERAVLRKDHQKKYGATVDLWSIGVTF 213 >6NT9-A nrPDB Length = 742 Score = 67.0 bits (162), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 61/211 (28%), Positives = 89/211 (42%), Gaps = 34/211 (16%) Query: 19 IGEGAYGKVFKARDLKNGGRFVA--------LKRVRVQTGEEGMPLSTIREVAVLRHLET 70 +G+GA VF+ R K G F L+ V VQ +RE VL+ L Sbjct: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ----------MREFEVLKKLN- 63 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130 H N+V+LF + T R L + F T + G+P ++ ++ Sbjct: 64 --HKNIVKLFAI-EEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVV 120 Query: 131 RGLDFLHSHRVVHRDLKPQNIL--VTSSGQ--IKLADFGLARIYSFQMALTSVVVTLWYR 186 G++ L + +VHR++KP NI+ + GQ KL DFG AR S+ T Y Sbjct: 121 GGMNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYL 180 Query: 187 APEVL--------LQSSYATPVDLWSVGCIF 209 P++ Q Y VDLWS+G F Sbjct: 181 HPDMYERAVLRKDHQKKYGATVDLWSIGVTF 211 >5LPZ-A nrPDB Length = 332 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 60/221 (27%), Positives = 105/221 (47%), Gaps = 23/221 (10%) Query: 6 LCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIRE-VAV 64 L +A + + IG G +G V+KA + G VA+K++ +G+ RE +A Sbjct: 12 LLQATNGFHNDSLIGSGGFGDVYKA--ILKDGSAVAIKKLIHVSGQGD------REFMAE 63 Query: 65 LRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPGVPTE--T 121 + + +H N+V L C V + LV+E + L L + GV T Sbjct: 64 METIGKIKHRNLVPLLGYCKVG-----DERLLVYEFMKYGSLEDVLHDPKKAGVKLNWST 118 Query: 122 IKDMMFQLLRGLDFLH---SHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSF---QMA 175 + + RGL FLH S ++HRD+K N+L+ + + +++DFG+AR+ S ++ Sbjct: 119 RRKIAIGSARGLAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLS 178 Query: 176 LTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRK 216 ++++ T Y PE +T D++S G + E+ K Sbjct: 179 VSTLAGTPGYVPPEYYQSFRCSTKGDVYSYGVVLLELLTGK 219 >2VD5-A nrPDB Length = 412 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 52/152 (34%), Positives = 73/152 (48%), Gaps = 11/152 (7%) Query: 91 ETKLTLVFEH-VDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQ 149 E L LV E+ V DL T L K E +P E + + +++ +D +H VHRD+KP Sbjct: 133 ENYLYLVMEYYVGGDLLTLLSKFGER-IPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPD 191 Query: 150 NILVTSSGQIKLADFGLARIYSFQMALTSVVV--TLWYRAPEVL-------LQSSYATPV 200 NIL+ G I+LADFG + S+V T Y +PE+L SY Sbjct: 192 NILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPEC 251 Query: 201 DLWSVGCIFAEMFRRKPLFRGSSDVDQLGKIL 232 D W++G EMF + F S + GKI+ Sbjct: 252 DWWALGVFAYEMFYGQTPFYADSTAETYGKIV 283 >5U6B-A nrPDB Length = 307 Score = 66.6 bits (161), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 79/320 (24%), Positives = 134/320 (41%), Gaps = 59/320 (18%) Query: 19 IGEGAYGKVFKARDLKNGGRF-VALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVV 77 +GEG +G V + + ++ VA+K +++ + E ++ F+HPNV+ Sbjct: 31 LGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKE---FDHPNVM 87 Query: 78 RLFDVCTVSRTDRET----KLTLVF-EHVDQDLTTYLDKVPEPGV--PTETIKDMMFQLL 130 RL VC ++RE+ + L F +H D ++ + V PT+ + M + Sbjct: 88 RLIGVC-FQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIA 146 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLA-RIYS---FQMALTSVVVTLWYR 186 G+++L + R +HRDL +N ++ + + +ADFGL+ +IY+ ++ + + W Sbjct: 147 SGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWI- 205 Query: 187 APEVLLQSSYATPVDLWSVGCIFAEMFRRK----PLFRGSSDVDQLGKILDVIGLPGEED 242 A E L Y + D+WS G E+ R P S D L Sbjct: 206 AIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYL-------------- 251 Query: 243 WPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQD 302 RQ ++ QP + +D L L+ +C NP R P F + Sbjct: 252 --------RQG--NRLKQPADC----LDGL-YALMSRCWELNPQDR---------PSFTE 287 Query: 303 LERCKENLDSHLPPSQNTSE 322 L EN LPP+Q E Sbjct: 288 LREDLENTLKALPPAQEPDE 307 >6CKI-A nrPDB Length = 316 Score = 66.6 bits (161), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 79/300 (26%), Positives = 121/300 (40%), Gaps = 37/300 (12%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVR 78 +GEGA+ +V +L + A+K + Q G + REV +L + H NV+ Sbjct: 21 LGEGAHARVQTCINLITSQEY-AVKIIEKQPGH--IRSRVFREVEMLYQCQG--HRNVLE 75 Query: 79 LFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQ-LLRGLDFLH 137 + + E + LVFE + + L + + E ++ Q + LDFLH Sbjct: 76 -----LIEFFEEEDRFYLVFEKMRGG--SILSHIHKRRHFNELEASVVVQDVASALDFLH 128 Query: 138 SHRVVHRDLKPQNILVTSSGQ---IKLADFGLARIYSFQMALTSVVV--------TLWYR 186 + + HRDLKP+NIL Q +K+ DFGL + + + Y Sbjct: 129 NKGIAHRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPELLTPCGSAEYM 188 Query: 187 APEVL-----LQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEE 241 APEV+ S Y DLWS+G I + P F G D G E Sbjct: 189 APEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSD--------CGWDRGE 240 Query: 242 DWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQ 301 P + ++ + +K I KDL+ K L + +R+SA L HP+ Q Sbjct: 241 ACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQ 300 >4EUT-A nrPDB Length = 396 Score = 66.6 bits (161), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 61/211 (28%), Positives = 89/211 (42%), Gaps = 34/211 (16%) Query: 19 IGEGAYGKVFKARDLKNGGRFVA--------LKRVRVQTGEEGMPLSTIREVAVLRHLET 70 +G+GA VF+ R K G F L+ V VQ +RE VL+ L Sbjct: 17 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ----------MREFEVLKKLN- 65 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130 H N+V+LF + T R L + F T + G+P ++ ++ Sbjct: 66 --HKNIVKLFAI-EEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVV 122 Query: 131 RGLDFLHSHRVVHRDLKPQNIL--VTSSGQ--IKLADFGLARIYSFQMALTSVVVTLWYR 186 G++ L + +VHR++KP NI+ + GQ KL DFG AR S+ T Y Sbjct: 123 GGMNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYL 182 Query: 187 APEVL--------LQSSYATPVDLWSVGCIF 209 P++ Q Y VDLWS+G F Sbjct: 183 HPDMYERAVLRKDHQKKYGATVDLWSIGVTF 213 >5LPV-A nrPDB Length = 296 Score = 66.6 bits (161), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 60/221 (27%), Positives = 105/221 (47%), Gaps = 23/221 (10%) Query: 6 LCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIRE-VAV 64 L +A + + IG G +G V+KA + G VA+K++ +G+ RE +A Sbjct: 12 LLQATNGFHNDSLIGSGGFGDVYKA--ILKDGSAVAIKKLIHVSGQGD------REFMAE 63 Query: 65 LRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTE--T 121 + + +H N+V L C V + LV+E + L L + GV T Sbjct: 64 METIGKIKHRNLVPLLGYCKVG-----DERLLVYEFMKYGSLEDVLHDPKKAGVKLNWST 118 Query: 122 IKDMMFQLLRGLDFLH---SHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSF---QMA 175 + + RGL FLH S ++HRD+K N+L+ + + +++DFG+AR+ S ++ Sbjct: 119 RRKIAIGSARGLAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLS 178 Query: 176 LTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRK 216 ++++ T Y PE +T D++S G + E+ K Sbjct: 179 VSTLAGTPGYVPPEYYQSFRCSTKGDVYSYGVVLLELLTGK 219 >3PFQ-A nrPDB Length = 674 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 42/143 (29%), Positives = 69/143 (48%), Gaps = 4/143 (2%) Query: 93 KLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNI 151 +L V E+V+ DL ++ +V P ++ GL FL S +++RDLK N+ Sbjct: 416 RLYFVMEYVNGGDLMYHIQQVGRFKEPHAVF--YAAEIAIGLFFLQSKGIIYRDLKLDNV 473 Query: 152 LVTSSGQIKLADFGLARIYSFQMALTSVVV-TLWYRAPEVLLQSSYATPVDLWSVGCIFA 210 ++ S G IK+ADFG+ + + T T Y APE++ Y VD W+ G + Sbjct: 474 MLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLY 533 Query: 211 EMFRRKPLFRGSSDVDQLGKILD 233 EM + F G + + I++ Sbjct: 534 EMLAGQAPFEGEDEDELFQSIME 556 >3G0E-A nrPDB Length = 336 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 59/221 (26%), Positives = 96/221 (43%), Gaps = 36/221 (16%) Query: 19 IGEGAYGKVFKARDL----KNGGRFVALKRVRVQ---TGEEGMPLSTIREVAVLRHLETF 71 +G GA+GKV +A + VA+K ++ T E + + E+ VL +L Sbjct: 54 LGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREAL----MSELKVLSYLGN- 108 Query: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMM----- 126 H N+V L CT+ L + DL +L + + + ++T +M Sbjct: 109 -HMNIVNLLGACTIG----GPTLVITEYCCYGDLLNFLRRKRDSFICSKTSPAIMEDDEL 163 Query: 127 -----------FQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY---SF 172 +Q+ +G+ FL S +HRDL +NIL+T K+ DFGLAR S Sbjct: 164 ALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSN 223 Query: 173 QMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMF 213 + + + + + APE + Y D+WS G E+F Sbjct: 224 YVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELF 264 >6BXI-A nrPDB Length = 333 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 67/261 (25%), Positives = 111/261 (42%), Gaps = 49/261 (18%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR-EVAVLRHLE 69 + +E + IG GA+G+V + K+ G A+K +R E + IR E +L + Sbjct: 6 EDFESLKVIGRGAFGEV-RLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEAD 64 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPGVPTETIKDMMFQ 128 + VV++F S D+ L L+ E + D+ T L K + + E + + + Sbjct: 65 SLW---VVKMF----YSFQDK-LNLYLIMEFLPGGDMMTLLMK--KDTLTEEETQFYIAE 114 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLA--------------------R 168 + +D +H +HRD+KP N+L+ S G +KL+DFGL Sbjct: 115 TVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPS 174 Query: 169 IYSFQMALTSVVVTLW----------------YRAPEVLLQSSYATPVDLWSVGCIFAEM 212 ++FQ + W Y APEV +Q+ Y D WS+G I EM Sbjct: 175 DFTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEM 234 Query: 213 FRRKPLFRGSSDVDQLGKILD 233 P F + + K+++ Sbjct: 235 LIGYPPFCSETPQETYKKVMN 255 >3VHK-A nrPDB Length = 368 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 39/117 (33%), Positives = 59/117 (50%), Gaps = 12/117 (10%) Query: 109 LDKVPEPGVPTETIKDMM---------FQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQI 159 L V E P + KD + FQ+ +G++FL S + +HRDL +NIL++ + Sbjct: 180 LSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVV 239 Query: 160 KLADFGLAR-IYS--FQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMF 213 K+ DFGLAR IY + + L + APE + Y D+WS G + E+F Sbjct: 240 KICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIF 296 >2I0E-A nrPDB Length = 353 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 42/143 (29%), Positives = 69/143 (48%), Gaps = 4/143 (2%) Query: 93 KLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNI 151 +L V E+V+ DL ++ +V P ++ GL FL S +++RDLK N+ Sbjct: 95 RLYFVMEYVNGGDLMYHIQQVGRFKEPHAVF--YAAEIAIGLFFLQSKGIIYRDLKLDNV 152 Query: 152 LVTSSGQIKLADFGLARIYSFQMALTSVVV-TLWYRAPEVLLQSSYATPVDLWSVGCIFA 210 ++ S G IK+ADFG+ + + T T Y APE++ Y VD W+ G + Sbjct: 153 MLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLY 212 Query: 211 EMFRRKPLFRGSSDVDQLGKILD 233 EM + F G + + I++ Sbjct: 213 EMLAGQAPFEGEDEDELFQSIME 235 >6FEX-A nrPDB Length = 321 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 48/170 (28%), Positives = 87/170 (51%), Gaps = 23/170 (13%) Query: 59 IREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYL------DK 111 ++EV ++ L+ PN++RL VC ++ L ++ ++++ DL +L DK Sbjct: 78 LKEVKIMSRLK---DPNIIRLLGVCV-----QDDPLCMITDYMENGDLNQFLSAHQLEDK 129 Query: 112 VPE--PGVPTETIKDMMF---QLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGL 166 E PG PT + ++ Q+ G+ +L + VHRDL +N LV + IK+ADFG+ Sbjct: 130 AAEGAPGDPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGM 189 Query: 167 AR-IYS--FQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMF 213 +R +Y+ + V+ + + A E +L + T D+W+ G E+ Sbjct: 190 SRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVL 239 >4TPT-A nrPDB Length = 303 Score = 65.9 bits (159), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 64/250 (25%), Positives = 111/250 (44%), Gaps = 39/250 (15%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVR 78 +G+G +G+ K G V + +R +E + + EV V+R L+ HPNV++ Sbjct: 8 LGKGFFGQAIKVTHKATGKVMVMKELIRC---DEETQKTFLTEVKVMRSLD---HPNVLK 61 Query: 79 LFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHS 138 V ++ KL L+ E+++ + +P P + + G+ +LHS Sbjct: 62 FIGVLY-----KDKKLNLLTEYIEGGTLKDFLRSMDP-FPWQQKVRFAKGIASGMAYLHS 115 Query: 139 HRVVHRDLKPQNILVTSSGQIKLADFGLARIY-------SFQMALT-------------- 177 ++HRDL N L+ + +ADFGL+R+ + A T Sbjct: 116 MCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRY 175 Query: 178 SVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGL 237 +VV ++ APE+L SY VD++S G + E+ + + +D D L + LD GL Sbjct: 176 TVVGNPYWMAPEMLNGKSYDETVDIFSFGIVLCEI-----IGQVYADPDCLPRTLD-FGL 229 Query: 238 PGEEDWPRDV 247 + W + V Sbjct: 230 NVKLFWEKFV 239 >5SYS-A nrPDB Length = 286 Score = 65.9 bits (159), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 53/198 (26%), Positives = 94/198 (47%), Gaps = 17/198 (8%) Query: 18 EIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVV 77 ++G+G +G+ + NG VA+K ++ T P + ++E V++ L H +V Sbjct: 25 KLGQGCFGECWMG--TWNGTTRVAIKTLKPGTMS---PEAFLQEAQVMKKLR---HEKLV 76 Query: 78 RLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFL 136 +L+ V + E + +V E++ + L +L + + DM Q+ G+ ++ Sbjct: 77 QLYAVVS------EEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYV 130 Query: 137 HSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY--SFQMALTSVVVTLWYRAPEVLLQS 194 VHRDL+ NILV + K+ADFGLAR+ + A + + APE L Sbjct: 131 ERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYG 190 Query: 195 SYATPVDLWSVGCIFAEM 212 + D+WS G + E+ Sbjct: 191 RFTIKSDVWSFGILLTEL 208 >3DKO-A nrPDB Length = 318 Score = 65.9 bits (159), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 61/233 (26%), Positives = 103/233 (44%), Gaps = 16/233 (6%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTG-EEGMPLSTIREVAVLRHLETFEHPNVV 77 IG G +G+V R G R VA+ ++ G E + E +++ F+HPNVV Sbjct: 51 IGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQ---FDHPNVV 107 Query: 78 RLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLH 137 L V T R + +V E ++ + + + M+ + G+ +L Sbjct: 108 HLEGVVT-----RGKPVMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGMRYLA 162 Query: 138 SHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQ----MALTSVVVTLWYRAPEVLLQ 193 VHRDL +NILV S+ K++DFGL+R+ T + + + APE + Sbjct: 163 DMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQY 222 Query: 194 SSYATPVDLWSVGCIFAEM--FRRKPLFRGSSDVDQLGKILDVIGLPGEEDWP 244 + + D+WS G + E+ + +P + S+ D + I + LP D P Sbjct: 223 RKFTSASDVWSYGIVMWEVMSYGERP-YWDMSNQDVIKAIEEGYRLPAPMDCP 274 >4OTD-A nrPDB Length = 341 Score = 65.5 bits (158), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 66/235 (28%), Positives = 111/235 (47%), Gaps = 30/235 (12%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFV--ALKRVRVQTGEEGMPLSTIREVAVLRHL 68 + ++ +A +G G +GKV + +G F ALK+ + +E S + E +L + Sbjct: 12 EDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVE--SLMCEKRILAAV 69 Query: 69 ETFEHPNVVRLFD-------VCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTET 121 + HP +V LF VC V L L H+ D+ + EP Sbjct: 70 TSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLML---HIHSDVFS------EP------ 114 Query: 122 IKDMMFQ--LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLAR-IYSFQMALTS 178 + + + ++ GL FLH H++V+RDLK N+L+ + G +K+ADFGL + + ++ Sbjct: 115 -RAIFYSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTST 173 Query: 179 VVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILD 233 T + APEVL +SY VD W +G + EM + F G + + I++ Sbjct: 174 FCGTPEFLAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVN 228 >4CRS-A nrPDB Length = 341 Score = 65.5 bits (158), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 64/233 (27%), Positives = 110/233 (47%), Gaps = 26/233 (11%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVR----VQTGEEGMPLSTIREVAVLR 66 Q + C A + G +GKV A + KN A+K ++ V E S + E + Sbjct: 12 QDFRCCAVLLRGHFGKVLLA-EYKNTNEMFAIKALKKGDIVARDEVD---SLMCEKRIFE 67 Query: 67 HLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHV---DQDLTTYLDKVPEPGVPTETIK 123 + + HP +V LF C ++ + V E+ D + + D EP + Sbjct: 68 TVNSVRHPFLVNLF-ACFQTKE----HVCFVMEYAAGGDLMMHIHTDVFSEP-------R 115 Query: 124 DMMFQ--LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARI-YSFQMALTSVV 180 + + ++ GL +LH H++V+RDLK N+L+ + G +K+ADFGL + + ++ Sbjct: 116 AVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFC 175 Query: 181 VTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILD 233 T + APEVL ++SY VD W +G + EM + F G + + I++ Sbjct: 176 GTPEFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVN 228 >4Y12-A nrPDB Length = 375 Score = 65.5 bits (158), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 60/204 (29%), Positives = 100/204 (49%), Gaps = 18/204 (8%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETF 71 QYE I G G ++ A D GR V LK + V +G+ + +A + L Sbjct: 120 QYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGL-VHSGDA---EAQAMAMAERQFLAEV 175 Query: 72 EHPNVVRLFDVCTVSRTDRETKLT--LVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQL 129 HP++V++F+ V TDR +V E+V L + +P + ++ Sbjct: 176 VHPSIVQIFNF--VEHTDRHGDPVGYIVMEYVGGQ---SLKRSKGQKLPVAEAIAYLLEI 230 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFG-LARIYSFQMALTSVVVTLWYRAP 188 L L +LHS +V+ DLKP+NI++T Q+KL D G ++RI SF + T ++AP Sbjct: 231 LPALSYLHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINSFGY----LYGTPGFQAP 285 Query: 189 EVLLQSSYATPVDLWSVGCIFAEM 212 E+ +++ D+++VG A + Sbjct: 286 EI-VRTGPTVATDIYTVGRTLAAL 308 >3C51-A nrPDB Length = 543 Score = 65.5 bits (158), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 32/98 (32%), Positives = 54/98 (55%), Gaps = 1/98 (1%) Query: 128 QLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLA-RIYSFQMALTSVVVTLWYR 186 Q++ GL+ LH +++RDLKP+N+L+ G ++++D GLA + + Q T + Sbjct: 297 QIVSGLEHLHQRNIIYRDLKPENVLLDDDGNVRISDLGLAVELKAGQTKTKGYAGTPGFM 356 Query: 187 APEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSD 224 APE+LL Y VD +++G EM + FR + Sbjct: 357 APELLLGEEYDFSVDYFALGVTLYEMIAARGPFRARGE 394 >2PZI-A nrPDB Length = 681 Score = 65.1 bits (157), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 62/213 (29%), Positives = 102/213 (47%), Gaps = 18/213 (8%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETF 71 QYE I G G ++ A D GR V LK + V +G+ + +A + L Sbjct: 81 QYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGL-VHSGDA---EAQAMAMAERQFLAEV 136 Query: 72 EHPNVVRLFDVCTVSRTDRETKLT--LVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQL 129 HP++V++F+ V TDR +V E+V L + +P + ++ Sbjct: 137 VHPSIVQIFNF--VEHTDRHGDPVGYIVMEYVGGQ---SLKRSKGQKLPVAEAIAYLLEI 191 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFG-LARIYSFQMALTSVVVTLWYRAP 188 L L +LHS +V+ DLKP+NI++T Q+KL D G ++RI SF + T ++AP Sbjct: 192 LPALSYLHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINSFGY----LYGTPGFQAP 246 Query: 189 EVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRG 221 E+ +++ D+++VG A + P G Sbjct: 247 EI-VRTGPTVATDIYTVGRTLAALTLDLPTRNG 278 >3ZBF-A nrPDB Length = 322 Score = 65.1 bits (157), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 58/209 (27%), Positives = 97/209 (46%), Gaps = 18/209 (8%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET-FEHPNVV 77 +G GA+G+V++ + G +V V+T ++G E HL + F HPN++ Sbjct: 41 LGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNIL 100 Query: 78 RLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVP-----EPGVPTETIKDMMFQLLRG 132 + VC ++ E + ++ DL TYL K P + + D+ + +G Sbjct: 101 KQLGVCLLN----EPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKG 156 Query: 133 LDFLHSHRVVHRDLKPQNILV-----TSSGQIKLADFGLAR-IYS--FQMALTSVVVTLW 184 +L +HRDL +N LV TS +K+ DFGLAR IY + ++ + Sbjct: 157 CVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVR 216 Query: 185 YRAPEVLLQSSYATPVDLWSVGCIFAEMF 213 + APE L+ + T D+WS G + E+ Sbjct: 217 WMAPESLMDGIFTTQSDVWSFGILIWEIL 245 >1JPA-A nrPDB Length = 312 Score = 65.1 bits (157), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 53/204 (25%), Positives = 92/204 (45%), Gaps = 19/204 (9%) Query: 19 IGEGAYGKVFKARDLKNGGR--FVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNV 76 IG G +G+V G R FVA+K ++ E+ + E +++ F+HPNV Sbjct: 41 IGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEK-QRRDFLSEASIMGQ---FDHPNV 96 Query: 77 VRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFL 136 + L V T + T + ++ E ++ + + + M+ + G+ +L Sbjct: 97 IHLEGVVT-----KSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYL 151 Query: 137 HSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY-------SFQMALTSVVVTLWYRAPE 189 VHRDL +NILV S+ K++DFGL+R ++ AL + W APE Sbjct: 152 ADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRW-TAPE 210 Query: 190 VLLQSSYATPVDLWSVGCIFAEMF 213 + + + D+WS G + E+ Sbjct: 211 AIQYRKFTSASDVWSYGIVMWEVM 234 >1U59-A nrPDB Length = 287 Score = 64.7 bits (156), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 57/217 (26%), Positives = 101/217 (46%), Gaps = 23/217 (10%) Query: 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKA-RDLKNGGRFVALKRVRVQTGEEGMPLSTI 59 +++D L AD E+G G +G V + ++ VA+K ++ Q E+ + Sbjct: 6 LKRDNLLIAD------IELGCGNFGSVRQGVYRMRKKQIDVAIKVLK-QGTEKADTEEMM 58 Query: 60 REVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQD-LTTYLDKVPEPGVP 118 RE ++ L+ +P +VRL VC L LV E L +L E +P Sbjct: 59 REAQIMHQLD---NPYIVRLIGVCQAE------ALMLVMEMAGGGPLHKFLVGKREE-IP 108 Query: 119 TETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY----SFQM 174 + +++ Q+ G+ +L VHRDL +N+L+ + K++DFGL++ S+ Sbjct: 109 VSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYT 168 Query: 175 ALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAE 211 A ++ L + APE + +++ D+WS G E Sbjct: 169 ARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWE 205 >2VWV-A nrPDB Length = 302 Score = 64.7 bits (156), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 64/235 (27%), Positives = 108/235 (45%), Gaps = 18/235 (7%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIRE-VAVLRHLETFEHPNVV 77 IG G +G+V + R LK G+ + V ++T + G RE ++ + FEHPN++ Sbjct: 24 IGAGEFGEVCRGR-LKAPGKKESC--VAIKTLKGGYTERQRREFLSEASIMGQFEHPNII 80 Query: 78 RLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLH 137 RL V T S + ++ E ++ ++ + + M+ + G+ +L Sbjct: 81 RLEGVVTNS-----MPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGMRYLA 135 Query: 138 SHRVVHRDLKPQNILVTSSGQIKLADFGLARIY---SFQMALTSVV---VTLWYRAPEVL 191 VHRDL +NILV S+ K++DFGL+R S TS + + + + APE + Sbjct: 136 EMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTETSSLGGKIPIRWTAPEAI 195 Query: 192 LQSSYATPVDLWSVGCIFAEM--FRRKPLFRGSSDVDQLGKILDVIGLPGEEDWP 244 + + D WS G + E+ F +P + S+ D + I LP D P Sbjct: 196 AFRKFTSASDAWSYGIVMWEVMSFGERP-YWDMSNQDVINAIEQDYRLPPPPDCP 249 >2R2P-A nrPDB Length = 295 Score = 64.3 bits (155), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 62/235 (26%), Positives = 114/235 (48%), Gaps = 20/235 (8%) Query: 19 IGEGAYGKVFKARDLKNGGRF--VALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNV 76 IG G +G+V R G R VA+K ++V E+ + E +++ F+HPN+ Sbjct: 30 IGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEK-QRRDFLGEASIMGQ---FDHPNI 85 Query: 77 VRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQLLRGLDF 135 + L V T S+ + +V E+++ L T+L K + + M+ + G+ + Sbjct: 86 IHLEGVVTKSKP-----VMIVTEYMENGSLDTFLKKNDGQFTVIQLV-GMLRGISAGMKY 139 Query: 136 LHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSF--QMALTS--VVVTLWYRAPEVL 191 L VHRDL +NIL+ S+ K++DFGL+R+ + A T+ + + + APE + Sbjct: 140 LSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAI 199 Query: 192 LQSSYATPVDLWSVGCIFAEM--FRRKPLFRGSSDVDQLGKILDVIGLPGEEDWP 244 + + D+WS G + E+ + +P + ++ D + + + LP D P Sbjct: 200 AFRKFTSASDVWSYGIVMWEVVSYGERPYWE-MTNQDVIKAVEEGYRLPSPMDCP 253 >5XD6-A nrPDB Length = 305 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 63/227 (27%), Positives = 100/227 (44%), Gaps = 38/227 (16%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETF 71 Y + IGEG+YG+VF + G+ A+K++ + L+ + V+ LR Sbjct: 23 NYGSKSLIGEGSYGRVFYG--ILKSGKAAAIKKLDSSKQPDQEFLAQVSMVSRLRQ---- 76 Query: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVD----QDLTTYLDKV----PEPGVPTETIK 123 NVV L C D ++ L +E+ D+ V P P + Sbjct: 77 --ENVVALLGYCV----DGPLRV-LAYEYAPNGSLHDILHGRKGVKGAQPGPVLSWHQRV 129 Query: 124 DMMFQLLRGLDFLHSH---RVVHRDLKPQNILVTSSGQIKLADFGL--------ARIYSF 172 + RGL++LH V+HRD+K N+L+ K+ADF L AR++S Sbjct: 130 KIAVGAARGLEYLHEKANPHVIHRDIKSSNVLLFDDDVAKIADFDLSNQAPDMAARLHS- 188 Query: 173 QMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKPL 218 T V+ T Y APE + + +T D++S G + E+ RKP+ Sbjct: 189 ----TRVLGTFGYHAPEYAMTGTLSTKSDVYSFGVVLLELLTGRKPV 231 >3PLS-A nrPDB Length = 298 Score = 63.2 bits (152), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 62/219 (28%), Positives = 99/219 (45%), Gaps = 34/219 (15%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREV----AVLRH---LETF 71 IG+G +G V+ G ++ + R+Q + LS I E+ A LR + Sbjct: 29 IGKGHFGVVYH-------GEYIDQAQNRIQCAIKS--LSRITEMQQVEAFLREGLLMRGL 79 Query: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMM---FQ 128 HPNV+ L + L + DL ++ + P+ T+KD++ Q Sbjct: 80 NHPNVLALIGIMLPPEGLPHVLLPYM---CHGDLLQFI-RSPQR---NPTVKDLISFGLQ 132 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLAR------IYSFQMALTSVVVT 182 + RG+++L + VHRDL +N ++ S +K+ADFGLAR YS Q + + Sbjct: 133 VARGMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPV 192 Query: 183 LWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRR-KPLFR 220 W A E L + T D+WS G + E+ R P +R Sbjct: 193 KW-TALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYR 230 >5HIE-A nrPDB Length = 302 Score = 63.2 bits (152), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 52/225 (23%), Positives = 101/225 (44%), Gaps = 24/225 (10%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLE 69 D Q IG G++G V+K G++ V++ T ++ EV VLR Sbjct: 35 DGQITVGQRIGSGSFGTVYK-------GKWHGDVAVKMLTPQQLQAFKN--EVGVLRKTR 85 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQL 129 H N++ T + +L +V + + + + E + D+ Q Sbjct: 86 ---HVNILLFMGYST------KPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQT 136 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARI---YSFQMALTSVVVTLWYR 186 +G+D+LH+ ++HRDLK NI + +K+ DFGLA + +S + ++ + Sbjct: 137 AQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWM 196 Query: 187 APEVLL---QSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQL 228 APEV+ ++ Y+ D+++ G + E+ + + ++ DQ+ Sbjct: 197 APEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQI 241 >4PDO-A nrPDB Length = 299 Score = 63.2 bits (152), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 55/238 (23%), Positives = 108/238 (45%), Gaps = 19/238 (7%) Query: 19 IGEGAYGKVFKARDLKNGGRF---VALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPN 75 IG G +G+V+K + G+ VA+K ++ E+ + + E ++ F H N Sbjct: 42 IGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEK-QRVDFLGEAGIMGQ---FSHHN 97 Query: 76 VVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDF 135 ++RL V + + + ++ E+++ + + + M+ + G+ + Sbjct: 98 IIRLEGVIS-----KYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAGMKY 152 Query: 136 LHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVV----VTLWYRAPEVL 191 L + VHRDL +NILV S+ K++DFGL+R+ T + + + APE + Sbjct: 153 LANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAI 212 Query: 192 LQSSYATPVDLWSVGCIFAEM--FRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDV 247 + + D+WS G + E+ + +P + S+ + + I D LP D P + Sbjct: 213 SYRKFTSASDVWSFGIVMWEVMTYGERPYWE-LSNHEVMKAINDGFRLPTPMDCPSAI 269 >3LMG-A nrPDB Length = 344 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 50/203 (24%), Positives = 95/203 (46%), Gaps = 20/203 (9%) Query: 19 IGEGAYGKVFKARDLKNGGRF---VALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPN 75 +G G +G V K + G V +K + ++G + T +A+ + +H + Sbjct: 39 LGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAI----GSLDHAH 94 Query: 76 VVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPE--PGVPTETIKDMMFQLLRGL 133 +VRL +C S L LV +++ L + LD V + + + + + Q+ +G+ Sbjct: 95 IVRLLGLCPGS------SLQLVTQYLP--LGSLLDHVRQHRGALGPQLLLNWGVQIAKGM 146 Query: 134 DFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY---SFQMALTSVVVTLWYRAPEV 190 +L H +VHR+L +N+L+ S Q+++ADFG+A + Q+ + + + A E Sbjct: 147 YYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALES 206 Query: 191 LLQSSYATPVDLWSVGCIFAEMF 213 + Y D+WS G E+ Sbjct: 207 IHFGKYTHQSDVWSYGVTVWELM 229 >4NEU-A nrPDB Length = 333 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 49/182 (26%), Positives = 81/182 (44%), Gaps = 28/182 (15%) Query: 66 RHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDM 125 + + H VV+L V E K +LV E++++ ++ K E P + Sbjct: 74 KMMNRLRHSRVVKLLGVII-----EEGKYSLVMEYMEKGNLMHVLKA-EMSTPLSVKGRI 127 Query: 126 MFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQM----------- 174 + +++ G+ +LH V+H+DLKP+NILV + IK+AD GLA SF+M Sbjct: 128 ILEIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLA---SFKMWSKLNNEEHNE 184 Query: 175 ------ALTSVVVTLWYRAPEVL--LQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVD 226 TL+Y APE L + + D++S + +F K + + Sbjct: 185 LREVDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQ 244 Query: 227 QL 228 QL Sbjct: 245 QL 246 >4RT7-A nrPDB Length = 415 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 36/102 (35%), Positives = 57/102 (55%), Gaps = 12/102 (11%) Query: 121 TIKDMM---FQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALT 177 T +D++ +Q+ +G++FL VHRDL +N+LVT +K+ DFGLAR M+ + Sbjct: 241 TFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDI---MSDS 297 Query: 178 SVVVT------LWYRAPEVLLQSSYATPVDLWSVGCIFAEMF 213 + VV + + APE L + Y D+WS G + E+F Sbjct: 298 NYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIF 339 Score = 29.3 bits (64), Expect = 2.2, Method: Compositional matrix adjust. Identities = 25/95 (26%), Positives = 42/95 (44%), Gaps = 11/95 (11%) Query: 19 IGEGAYGKVFKARDL---KNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPN 75 +G GA+GKV A K G ++ + + + + E+ ++ L + H N Sbjct: 73 LGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGS--HEN 130 Query: 76 VVRLFDVCTVSRTDRETKLTLVFEH-VDQDLTTYL 109 +V L CT+S + L+FE+ DL YL Sbjct: 131 IVNLLGACTLS-----GPIYLIFEYCCYGDLLNYL 160 >2OZO-A nrPDB Length = 613 Score = 62.8 bits (151), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 56/224 (25%), Positives = 100/224 (44%), Gaps = 23/224 (10%) Query: 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR 60 +++D L AD E+G G +G V + + +V Q E+ +R Sbjct: 332 LKRDNLLIAD------IELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMR 385 Query: 61 EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQD-LTTYLDKVPEPGVPT 119 E ++ L+ +P +VRL VC L LV E L +L E +P Sbjct: 386 EAQIMHQLD---NPYIVRLIGVCQAE------ALMLVMEMAGGGPLHKFLVGKREE-IPV 435 Query: 120 ETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY----SFQMA 175 + +++ Q+ G+ +L VHR+L +N+L+ + K++DFGL++ S+ A Sbjct: 436 SNVAELLHQVSMGMKYLEEKNFVHRNLAARNVLLVNRHYAKISDFGLSKALGADDSYYTA 495 Query: 176 LTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEM--FRRKP 217 ++ L + APE + +++ D+WS G E + +KP Sbjct: 496 RSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKP 539 >1TKI-A nrPDB Length = 321 Score = 62.8 bits (151), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 71/311 (22%), Positives = 134/311 (43%), Gaps = 62/311 (19%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHL-- 68 ++Y ++G G +G V + + + ++A K V+V+ ++ + I + + RH Sbjct: 5 EKYMIAEDLGRGEFGIVHRCVETSSKKTYMA-KFVKVKGTDQVLVKKEISILNIARHRNI 63 Query: 69 ----ETFEH-PNVVRLFDVCTVSRTDRETKL-TLVFEHVDQDLTTYLDKVPEPGVPTETI 122 E+FE +V +F+ +S D ++ T FE ++++ +Y+ +V E Sbjct: 64 LHLHESFESMEELVMIFEF--ISGLDIFERINTSAFELNEREIVSYVHQVCE-------- 113 Query: 123 KDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTS--SGQIKLADFGLARIY----SFQMAL 176 L FLHSH + H D++P+NI+ + S IK+ +FG AR +F++ Sbjct: 114 ---------ALQFLHSHNIGHFDIRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLF 164 Query: 177 TSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIG 236 T+ Y APEV +T D+WS+G + + F ++ + I++ Sbjct: 165 TAP----EYYAPEVHQHDVVSTATDMWSLGTLVYVLLSGINPFLAETNQQIIENIMNA-- 218 Query: 237 LPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALS 296 + +AF S + + D + + L R++A AL Sbjct: 219 ---------EYTFDEEAFKEISIEAM------------DFVDRLLVKERKSRMTASEALQ 257 Query: 297 HPYF-QDLERC 306 HP+ Q +ER Sbjct: 258 HPWLKQKIERV 268 >3MDY-A nrPDB Length = 337 Score = 62.8 bits (151), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 85/308 (27%), Positives = 137/308 (44%), Gaps = 52/308 (16%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 +Q + V +IG+G YG+V+ K G VA+K T EE S RE + + + Sbjct: 37 KQIQMVKQIGKGRYGEVWMG---KWRGEKVAVKVFF--TTEEA---SWFRETEIYQTV-L 87 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFE-HVDQDLTTYLDKVPEPGVPTETIKDMMFQL 129 H N++ F + T T+L L+ + H + L YL + +++ + + Sbjct: 88 MRHENILG-FIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTT---LDAKSMLKLAYSS 143 Query: 130 LRGLDFLHSH--------RVVHRDLKPQNILVTSSGQIKLADFGLARIY-----SFQMAL 176 + GL LH+ + HRDLK +NILV +G +AD GLA + + Sbjct: 144 VSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPP 203 Query: 177 TSVVVTLWYRAPEVLLQS-------SYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLG 229 + V T Y PEVL +S SY D++S G I E+ RR G Sbjct: 204 NTRVGTKRYMPPEVLDESLNRNHFQSYIM-ADMYSFGLILWEVARRC----------VSG 252 Query: 230 KILDVIGLPGEEDWPRDVALP--RQAFHSKSAQPI--EKFVTD--IDELGKDLLLKCLTF 283 I++ LP + P D + R+ K +P ++ +D + ++GK L+ +C Sbjct: 253 GIVEEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGK-LMTECWAH 311 Query: 284 NPAKRISA 291 NPA R++A Sbjct: 312 NPASRLTA 319 >5C26-A nrPDB Length = 299 Score = 62.4 bits (150), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 59/232 (25%), Positives = 111/232 (47%), Gaps = 22/232 (9%) Query: 18 EIGEGAYGKVFKAR-DLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNV 76 E+G G +G V K +K + VA+K ++ + + + + E V++ L+ +P + Sbjct: 34 ELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLD---NPYI 90 Query: 77 VRLFDVCTVSRTDRETKLTLVFEHVDQD-LTTYLDKVPEPGVPTETIKDMMFQLLRGLDF 135 VR+ +C LV E + L YL + V + I +++ Q+ G+ + Sbjct: 91 VRMIGICEAE------SWMLVMEMAELGPLNKYLQQ--NRHVKDKNIIELVHQVSMGMKY 142 Query: 136 LHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY----SFQMALTSVVVTLWYRAPEVL 191 L VHRDL +N+L+ + K++DFGL++ ++ A T + + APE + Sbjct: 143 LEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECI 202 Query: 192 LQSSYATPVDLWSVGCIFAEMFR--RKPLFRG--SSDVDQLGKILDVIGLPG 239 +++ D+WS G + E F +KP +RG S+V + + + +G P Sbjct: 203 NYYKFSSKSDVWSFGVLMWEAFSYGQKP-YRGMKGSEVTAMLEKGERMGCPA 253 >1BYG-A nrPDB Length = 278 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 50/196 (25%), Positives = 92/196 (46%), Gaps = 17/196 (8%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVR 78 IG+G +G V D + G VA+K ++ + + + E +V+ L H N+V+ Sbjct: 29 IGKGEFGDVMLG-DYR--GNKVAVKCIK----NDATAQAFLAEASVMTQLR---HSNLVQ 78 Query: 79 LFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLH 137 L V + + L +V E++ + L YL + + + + +++L Sbjct: 79 LLGVIV----EEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE 134 Query: 138 SHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYA 197 + VHRDL +N+LV+ K++DFGL + S + V + APE L + ++ Sbjct: 135 GNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVK--WTAPEALREKKFS 192 Query: 198 TPVDLWSVGCIFAEMF 213 T D+WS G + E++ Sbjct: 193 TKSDVWSFGILLWEIY 208 >4YFF-A nrPDB Length = 311 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 53/201 (26%), Positives = 94/201 (46%), Gaps = 16/201 (7%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTI-REVAVLRHLETFEHPNVV 77 IG G++GKV+K R +N + VA+KR R T + REV++L L HP V+ Sbjct: 50 IGSGSFGKVYKGR-CRN--KIVAIKRYRANTYCSKSDVDMFCREVSILCQLN---HPCVI 103 Query: 78 RLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLH 137 + C + ++ +V +++ L + + ++ + + +G+++LH Sbjct: 104 QFVGACL----NDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLH 159 Query: 138 --SHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSF--QMALTSVVVTLWYRAPEVLLQ 193 + ++HRDL NIL+ G +ADFG +R + +T L + APEV Q Sbjct: 160 NLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQ 219 Query: 194 SS-YATPVDLWSVGCIFAEMF 213 + Y D++S E+ Sbjct: 220 CTRYTIKADVFSYALCLWEIL 240 >4P5Q-A nrPDB Length = 361 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 56/215 (26%), Positives = 108/215 (50%), Gaps = 21/215 (9%) Query: 19 IGEGAYGKVFKARDLKNGGR---FVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPN 75 +G G +G+V R LK + VA+K ++V E+ + E +++ F+HPN Sbjct: 41 VGAGEFGEVCSGR-LKLPSKKEISVAIKTLKVGYTEK-QRRDFLGEASIMGQ---FDHPN 95 Query: 76 VVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQLLRGLD 134 ++RL V T S+ + +V E+++ L ++L K + + M+ + G+ Sbjct: 96 IIRLEGVVTKSK-----PVMIVTEYMENGSLDSFLRKHDAQFTVIQLV-GMLRGIASGMK 149 Query: 135 FLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSF--QMALTS--VVVTLWYRAPEV 190 +L VHRDL +NIL+ S+ K++DFGL+R+ + A T+ + + + +PE Sbjct: 150 YLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEA 209 Query: 191 LLQSSYATPVDLWSVGCIFAEM--FRRKPLFRGSS 223 + + + D+WS G + E+ + +P + S+ Sbjct: 210 IAYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSN 244 >4FL3-A nrPDB Length = 635 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 59/231 (25%), Positives = 111/231 (48%), Gaps = 22/231 (9%) Query: 18 EIGEGAYGKVFKAR-DLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNV 76 E+G G +G V K +K + VA+K ++ + + + + E V++ L+ +P + Sbjct: 376 ELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLD---NPYI 432 Query: 77 VRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDF 135 VR+ +C LV E + L YL + V + I +++ Q+ G+ + Sbjct: 433 VRMIGICEAE------SWMLVMEMAELGPLNKYLQQNRH--VKDKNIIELVHQVSMGMKY 484 Query: 136 LHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY----SFQMALTSVVVTLWYRAPEVL 191 L VHRDL +N+L+ + K++DFGL++ ++ A T + + APE + Sbjct: 485 LEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECI 544 Query: 192 LQSSYATPVDLWSVGCIFAEMFR--RKPLFRG--SSDVDQLGKILDVIGLP 238 +++ D+WS G + E F +KP +RG S+V + + + +G P Sbjct: 545 NYYKFSSKSDVWSFGVLMWEAFSYGQKP-YRGMKGSEVTAMLEKGERMGCP 594 >5WNO-A nrPDB Length = 330 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 53/216 (24%), Positives = 96/216 (44%), Gaps = 20/216 (9%) Query: 18 EIGEGAYGKVFKA----RDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEH 73 ++G GA+G VF + KN VA+K + + L + LRH Sbjct: 29 KLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTDQSQTDEMLEEATNMFRLRH------ 82 Query: 74 PNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGL 133 N++++ C D K+ ++ + +L +L K+ + + +Q+ G+ Sbjct: 83 DNLLKIIGFCM---HDDGLKIVTIYRPLG-NLQNFL-KLHKENLGAREQVLYCYQIASGM 137 Query: 134 DFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSF---QMALTSVVVTLWYRAPEV 190 +L RVVHRDL +N+LV +++ DFGL++I + + S V + + A E+ Sbjct: 138 QYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIEI 197 Query: 191 LLQSSYATPVDLWSVGCIFAEM--FRRKPLFRGSSD 224 + Y D+W+ G E+ F + P S+D Sbjct: 198 FSKHCYTHASDVWAFGVTCWEIITFGQSPYQGMSTD 233 >1K9A-A nrPDB Length = 450 Score = 62.0 bits (149), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 50/196 (25%), Positives = 92/196 (46%), Gaps = 17/196 (8%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVR 78 IG+G +G V D + G VA+K ++ + + + E +V+ L H N+V+ Sbjct: 201 IGKGEFGDVMLG-DYR--GNKVAVKCIK----NDATAQAFLAEASVMTQLR---HSNLVQ 250 Query: 79 LFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLH 137 L V + + L +V E++ + L YL + + + + +++L Sbjct: 251 LLGVIV----EEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE 306 Query: 138 SHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYA 197 + VHRDL +N+LV+ K++DFGL + S + V + APE L + ++ Sbjct: 307 GNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVK--WTAPEALREKKFS 364 Query: 198 TPVDLWSVGCIFAEMF 213 T D+WS G + E++ Sbjct: 365 TKSDVWSFGILLWEIY 380 >4H1J-A nrPDB Length = 293 Score = 61.6 bits (148), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 50/211 (23%), Positives = 102/211 (48%), Gaps = 24/211 (11%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLST----IREVAVLRHLETFEHP 74 +GEG +G+V++ + G + V V+T ++ L + E ++++L+ HP Sbjct: 32 LGEGFFGEVYEGVYTNHKGEKI---NVAVKTCKKDCTLDNKEKFMSEAVIMKNLD---HP 85 Query: 75 NVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLD 134 ++V+L + + E ++ + +L YL++ + + T+ Q+ + + Sbjct: 86 HIVKLIGI-----IEEEPTWIIMELYPYGELGHYLER-NKNSLKVLTLVLYSLQICKAMA 139 Query: 135 FLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYS----FQMALTSVVVTLWYRAPEV 190 +L S VHRD+ +NILV S +KL DFGL+R ++ ++T + + + +PE Sbjct: 140 YLESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIK--WMSPES 197 Query: 191 LLQSSYATPVDLWSVGCIFAEM--FRRKPLF 219 + + T D+W E+ F ++P F Sbjct: 198 INFRRFTTASDVWMFAVCMWEILSFGKQPFF 228 >6BSD-A nrPDB Length = 876 Score = 61.6 bits (148), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 49/177 (27%), Positives = 86/177 (48%), Gaps = 31/177 (17%) Query: 59 IREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYL------DK 111 ++EV ++ L+ PN++RL VC ++ L ++ ++++ DL +L DK Sbjct: 633 LKEVKIMSRLKD---PNIIRLLGVCV-----QDDPLCMITDYMENGDLNQFLSAHQLEDK 684 Query: 112 VPEPGVPTE-------TIKDMMF-----QLLRGLDFLHSHRVVHRDLKPQNILVTSSGQI 159 E G P + TI M Q+ G+ +L + VHRDL +N LV + I Sbjct: 685 AAE-GAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTI 743 Query: 160 KLADFGLAR-IYS--FQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMF 213 K+ADFG++R +Y+ + V+ + + A E +L + T D+W+ G E+ Sbjct: 744 KIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVL 800 >1U54-B nrPDB Length = 291 Score = 61.6 bits (148), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 65/254 (25%), Positives = 112/254 (44%), Gaps = 30/254 (11%) Query: 9 ADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALK----RVRVQTGEEGMPLSTIREVAV 64 ++ + ++G+G++G V + G+ V++ + V + E M IREV Sbjct: 16 GEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMD-DFIREVNA 74 Query: 65 LRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKV--PEPGVPTETI 122 + L+ H N++RL+ V T+L L + LD++ + T+ Sbjct: 75 MHSLD---HRNLIRLYGVVLTPPMKMVTELA--------PLGSLLDRLRKHQGHFLLGTL 123 Query: 123 KDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY-----SFQMALT 177 Q+ G+ +L S R +HRDL +N+L+ + +K+ DFGL R + M Sbjct: 124 SRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEH 183 Query: 178 SVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFR--RKPL--FRGSSDVDQLGKILD 233 V W APE L +++ D W G EMF ++P GS + ++ K + Sbjct: 184 RKVPFAWC-APESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDK--E 240 Query: 234 VIGLPGEEDWPRDV 247 LP ED P+D+ Sbjct: 241 GERLPRPEDCPQDI 254 >4HZS-A nrPDB Length = 341 Score = 61.2 bits (147), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 65/254 (25%), Positives = 112/254 (44%), Gaps = 30/254 (11%) Query: 9 ADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALK----RVRVQTGEEGMPLSTIREVAV 64 ++ + ++G+G++G V + G+ V++ + V + E M IREV Sbjct: 10 GEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMD-DFIREVNA 68 Query: 65 LRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKV--PEPGVPTETI 122 + L+ H N++RL+ V T+L L + LD++ + T+ Sbjct: 69 MHSLD---HRNLIRLYGVVLTPPMKMVTELA--------PLGSLLDRLRKHQGHFLLGTL 117 Query: 123 KDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY-----SFQMALT 177 Q+ G+ +L S R +HRDL +N+L+ + +K+ DFGL R + M Sbjct: 118 SRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEH 177 Query: 178 SVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFR--RKPL--FRGSSDVDQLGKILD 233 V W APE L +++ D W G EMF ++P GS + ++ K + Sbjct: 178 RKVPFAWC-APESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDK--E 234 Query: 234 VIGLPGEEDWPRDV 247 LP ED P+D+ Sbjct: 235 GERLPRPEDCPQDI 248 >3KUL-B nrPDB Length = 325 Score = 61.2 bits (147), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 53/201 (26%), Positives = 94/201 (46%), Gaps = 15/201 (7%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTG-EEGMPLSTIREVAVLRHLETFEHPNVV 77 IG G G+V R G R V + ++ G E + E +++ F+HPN++ Sbjct: 57 IGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGYTERQRRDFLSEASIMGQ---FDHPNII 113 Query: 78 RLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFL 136 RL V T R +V E+++ L T+L + + + M+ + G+ +L Sbjct: 114 RLEGVVTRGRL-----AMIVTEYMENGSLDTFL-RTHDGQFTIMQLVGMLRGVGAGMRYL 167 Query: 137 HSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYS----FQMALTSVVVTLWYRAPEVLL 192 VHRDL +N+LV S+ K++DFGL+R+ T + + + APE + Sbjct: 168 SDLGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTAPEAIA 227 Query: 193 QSSYATPVDLWSVGCIFAEMF 213 ++++ D+WS G + E+ Sbjct: 228 FRTFSSASDVWSFGVVMWEVL 248 >3OMV-A nrPDB Length = 307 Score = 60.8 bits (146), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 53/216 (24%), Positives = 98/216 (45%), Gaps = 19/216 (8%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVR 78 IG G++G V+K + +G V + +V T E+ EVAVLR H N++ Sbjct: 44 IGSGSFGTVYKGK--WHGDVAVKILKVVDPTPEQFQAFRN--EVAVLRKTR---HVNILL 96 Query: 79 LFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHS 138 T + L +V + + V E + D+ Q +G+D+LH+ Sbjct: 97 FMGYMT------KDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHA 150 Query: 139 HRVVHRDLKPQNILVTSSGQIKLADFGLARI---YSFQMALTSVVVTLWYRAPEVLL--- 192 ++HRD+K NI + +K+ DFGLA + +S + ++ + APEV+ Sbjct: 151 KNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQD 210 Query: 193 QSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQL 228 + ++ D++S G + E+ + + ++ DQ+ Sbjct: 211 NNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQI 246 >5TE0-A nrPDB Length = 347 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 59/211 (27%), Positives = 92/211 (43%), Gaps = 24/211 (11%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVR 78 + EG + VF R + G ALKR+ V E + + RE+ ++R L H N+V Sbjct: 27 LAEGGFAIVFLVR--TSNGMKCALKRMFVNN-EHDLQVCK-REIQIMRDLSG--HKNIVG 80 Query: 79 LFD--VCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFL 136 D + VS D L L+ + +++ + G + + + L Sbjct: 81 YIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARL 140 Query: 137 HSHR--VVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVV----------VTLW 184 H + ++HRDLK +NIL+ G L DFG A FQ T V TL Sbjct: 141 HQCKTPIIHRDLKVENILLHDRGHYVLCDFGSA-TNKFQNPQTEGVNAVEDEIKKYTTLS 199 Query: 185 YRAPEVLLQSS---YATPVDLWSVGCIFAEM 212 YRAPE++ S T D+W++GC+ ++ Sbjct: 200 YRAPEMVNLYSGKIITTKADIWALGCLLYKL 230 >6J5U-C nrPDB Length = 426 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 60/209 (28%), Positives = 93/209 (44%), Gaps = 24/209 (11%) Query: 19 IGEGAYGKVFKA--------RDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 +GEG +G VFK G VA+K+++ + G +G + EV L L Sbjct: 92 LGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQLKPE-GFQGHK-EWLTEVNYLGQLS- 148 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQL 129 HPN+V L C + E +L LV+E + + L +L + + + Sbjct: 149 --HPNLVLLVGYCA----EGENRL-LVYEFMPKGSLENHLFRRGAQPLTWAIRMKVAVGA 201 Query: 130 LRGLDFLHSHR--VVHRDLKPQNILVTSSGQIKLADFGLAR---IYSFQMALTSVVVTLW 184 +GL FLH + V++RD K NIL+ + KL+DFGLA+ T V+ T Sbjct: 202 AKGLTFLHEAKSQVIYRDFKAANILLDADFNAKLSDFGLAKAGPTGDNTHVSTKVIGTHG 261 Query: 185 YRAPEVLLQSSYATPVDLWSVGCIFAEMF 213 Y APE + D++S G + E+ Sbjct: 262 YAAPEYVATGRLTAKSDVYSFGVVLLELI 290 >4IDT-A nrPDB Length = 356 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 59/205 (28%), Positives = 93/205 (45%), Gaps = 30/205 (14%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQT--GEEGMPLSTIREVAVLRHLETFEHPNV 76 +G G++G+V + D K G A+K+VR++ EE M + + P + Sbjct: 82 LGRGSFGEVHRMED-KQTGFQCAVKKVRLEVFRAEELMACAGLTS------------PRI 128 Query: 77 VRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPG-VPTETIKDMMFQLLRGLDF 135 V L+ RE +F + + + V E G +P + + Q L GL++ Sbjct: 129 VPLYGAV------REGPWVNIFMELLEG-GSLGQLVKEQGCLPEDRALYYLGQALEGLEY 181 Query: 136 LHSHRVVHRDLKPQNILVTSSG-QIKLADFGLARIYS----FQMALTSVVV--TLWYRAP 188 LHS R++H D+K N+L++S G L DFG A + LT + T + AP Sbjct: 182 LHSRRILHGDVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKDLLTGDYIPGTETHMAP 241 Query: 189 EVLLQSSYATPVDLWSVGCIFAEMF 213 EV+L S VD+WS C+ M Sbjct: 242 EVVLGRSCDAKVDVWSSCCMMLHML 266 >3I81-A nrPDB Length = 315 Score = 59.3 bits (142), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 52/213 (24%), Positives = 99/213 (46%), Gaps = 29/213 (13%) Query: 18 EIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRH-LETFEHPNV 76 E+G+G++G V++ K V E + + T+ E A +R +E +V Sbjct: 25 ELGQGSFGMVYEG----------VAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASV 74 Query: 77 VRLFDVCTVSR-----TDRETKLTLVFEHVDQDLTTYLDKV-PE----PGVPTETIKDMM 126 ++ F+ V R + + L ++ DL +YL + PE P + ++ M+ Sbjct: 75 MKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMI 134 Query: 127 ---FQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLAR-IYS---FQMALTSV 179 ++ G+ +L++++ VHRDL +N +V +K+ DFG+ R IY ++ + Sbjct: 135 QMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGL 194 Query: 180 VVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEM 212 + W +PE L + T D+WS G + E+ Sbjct: 195 LPVRWM-SPESLKDGVFTTYSDVWSFGVVLWEI 226 >2Y6O-A nrPDB Length = 291 Score = 59.3 bits (142), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 59/234 (25%), Positives = 110/234 (47%), Gaps = 18/234 (7%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIRE-VAVLRHLETFEHPNVV 77 IG G +G+V R G R + V ++T + G R+ ++ + F+HPN++ Sbjct: 22 IGVGEFGEVCSGRLKVPGKREIC---VAIKTLKAGYTDKQRRDFLSEASIMGQFDHPNII 78 Query: 78 RLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFL 136 L V T + + ++ E+++ L +L K + + M+ + G+ +L Sbjct: 79 HLEGVVTKCKP-----VMIITEYMENGSLDAFLRKNDGRFTVIQLV-GMLRGIGSGMKYL 132 Query: 137 HSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSF--QMALTS--VVVTLWYRAPEVLL 192 VHRDL +NILV S+ K++DFG++R+ + A T+ + + + APE + Sbjct: 133 SDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIA 192 Query: 193 QSSYATPVDLWSVGCIFAEM--FRRKPLFRGSSDVDQLGKILDVIGLPGEEDWP 244 + + D+WS G + E+ + +P + S+ D + I + LP D P Sbjct: 193 YRKFTSASDVWSYGIVMWEVMSYGERPYW-DMSNQDVIKAIEEGYRLPPPMDCP 245 >3QD2-B nrPDB Length = 332 Score = 58.9 bits (141), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 40/126 (31%), Positives = 64/126 (50%), Gaps = 18/126 (14%) Query: 125 MMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY----SFQMALTSV- 179 + Q+ ++FLHS ++HRDLKP NI T +K+ DFGL Q LT + Sbjct: 169 IFIQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMP 228 Query: 180 --------VVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKI 231 V T Y +PE + ++Y+ VD++S+G I E+ L+ S+ ++++ I Sbjct: 229 AYATHTGQVGTKLYMSPEQIHGNNYSHKVDIFSLGLILFEL-----LYSFSTQMERVRII 283 Query: 232 LDVIGL 237 DV L Sbjct: 284 TDVRNL 289 Score = 37.7 bits (86), Expect = 0.007, Method: Compositional matrix adjust. Identities = 23/70 (32%), Positives = 38/70 (54%), Gaps = 5/70 (7%) Query: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 +E + +G G +G VF+A++ + + A+KR+R+ E +REV L L E Sbjct: 8 FEPIQCMGRGGFGVVFEAKNKVDDCNY-AIKRIRLPNRELARE-KVMREVKALAKL---E 62 Query: 73 HPNVVRLFDV 82 HP +VR F+ Sbjct: 63 HPGIVRYFNA 72 >3Q4U-A nrPDB Length = 301 Score = 58.9 bits (141), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 78/299 (26%), Positives = 129/299 (43%), Gaps = 43/299 (14%) Query: 14 ECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEH 73 ECV G+G YG+V++ G VA+K + + + + +LRH Sbjct: 14 ECV---GKGRYGEVWRG---SWQGENVAVKIFSSRDEKSWFRETELYNTVMLRH------ 61 Query: 74 PNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGL 133 N++ SR T+L L+ + ++ + D + + T + ++ + GL Sbjct: 62 ENILGFIASDMTSR-HSSTQLWLITHY--HEMGSLYDYLQLTTLDTVSCLRIVLSIASGL 118 Query: 134 DFLHSH--------RVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSV-----V 180 LH + HRDLK +NILV +GQ +AD GLA ++S V V Sbjct: 119 AHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRV 178 Query: 181 VTLWYRAPEVLLQS-------SYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILD 233 T Y APEVL ++ SY VD+W+ G + E+ RR + D D Sbjct: 179 GTKRYMAPEVLDETIQVDCFDSYKR-VDIWAFGLVLWEVARR--MVSNGIVEDYKPPFYD 235 Query: 234 VI-GLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISA 291 V+ P ED + V + +Q + + + +T + +L K+ C NP+ R++A Sbjct: 236 VVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKE----CWYQNPSARLTA 290 >4G3E-A nrPDB Length = 352 Score = 58.5 bits (140), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 52/203 (25%), Positives = 91/203 (44%), Gaps = 26/203 (12%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVR 78 +G G++G+V + +D K G A+K+VR++ + V L P +V Sbjct: 82 VGRGSFGEVHRMKD-KQTGFQCAVKKVRLE----------VFRVEELVACAGLSSPRIVP 130 Query: 79 LFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPG-VPTETIKDMMFQLLRGLDFLH 137 L+ RE +F + + + + + G +P + + Q L GL++LH Sbjct: 131 LYGAV------REGPWVNIFMELLEG-GSLGQLIKQMGCLPEDRALYYLGQALEGLEYLH 183 Query: 138 SHRVVHRDLKPQNILVTSSG-QIKLADFGLARIYSFQMALTSVVV------TLWYRAPEV 190 + R++H D+K N+L++S G + L DFG A S++ T + APEV Sbjct: 184 TRRILHGDVKADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAPEV 243 Query: 191 LLQSSYATPVDLWSVGCIFAEMF 213 ++ VD+WS C+ M Sbjct: 244 VMGKPCDAKVDIWSSCCMMLHML 266 >3AOX-A nrPDB Length = 344 Score = 58.2 bits (139), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 54/210 (25%), Positives = 96/210 (45%), Gaps = 23/210 (10%) Query: 19 IGEGAYGKVFKAR--DLKNGGR--FVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHP 74 +G GA+G+V++ + + N VA+K + E+ L + E ++ F H Sbjct: 55 LGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDE-LDFLMEALII---SKFNHQ 110 Query: 75 NVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKV-PEPGVPTETIKDMMFQLLR-- 131 N+VR V ++ R L L+ DL ++L + P P P+ + + R Sbjct: 111 NIVRCIGV-SLQSLPRFILLELM---AGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDI 166 Query: 132 --GLDFLHSHRVVHRDLKPQNILVTSSGQ---IKLADFGLAR-IY--SFQMALTSVVVTL 183 G +L + +HRD+ +N L+T G K+ DFG+AR IY S+ ++ + Sbjct: 167 ACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPV 226 Query: 184 WYRAPEVLLQSSYATPVDLWSVGCIFAEMF 213 + PE ++ + + D WS G + E+F Sbjct: 227 KWMPPEAFMEGIFTSKTDTWSFGVLLWEIF 256 >5UIU-A nrPDB Length = 323 Score = 57.4 bits (137), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 33/90 (36%), Positives = 49/90 (54%), Gaps = 4/90 (4%) Query: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYS--FQMALTS-VVVTLWYRA 187 G++FLH + +HRD+K NIL+ + K++DFGLAR Q +TS +V T Y A Sbjct: 160 NGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMA 219 Query: 188 PEVLLQSSYATPVDLWSVGCIFAEMFRRKP 217 PE L+ D++S G + E+ P Sbjct: 220 PEA-LRGEITPKSDIYSFGVVLLEIITGLP 248 >3G2F-A nrPDB Length = 336 Score = 56.6 bits (135), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 65/232 (28%), Positives = 98/232 (42%), Gaps = 39/232 (16%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVR 78 IG G YG V+K R VA+K + + I V ++ EH N+ R Sbjct: 21 IGRGRYGAVYKG---SLDERPVAVKVFSFANRQNFINEKNIYRVPLM------EHDNIAR 71 Query: 79 LFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLH 137 D + LV E+ + L YL V + + + RGL +LH Sbjct: 72 FIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSS---CRLAHSVTRGLAYLH 128 Query: 138 SH---------RVVHRDLKPQNILVTSSGQIKLADFGLA-RIYSFQM--------ALTSV 179 + + HRDL +N+LV + G ++DFGL+ R+ ++ A S Sbjct: 129 TELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPGEEDNAAISE 188 Query: 180 VVTLWYRAPEVLLQS-------SYATPVDLWSVGCIFAEMFRR-KPLFRGSS 223 V T+ Y APEVL + S VD++++G I+ E+F R LF G S Sbjct: 189 VGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGES 240 >4X7Q-B nrPDB Length = 312 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 64/213 (30%), Positives = 93/213 (43%), Gaps = 20/213 (9%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLS----TIREVAVL 65 + +Y +G+G +G VF L + + VA+K + PLS EVA+L Sbjct: 30 EAEYRLGPLLGKGGFGTVFAGHRLTDRLQ-VAIKVIPRNRVLGWSPLSDSVTCPLEVALL 88 Query: 66 RHLETFE-HPNVVRLFDVCTVSRTDRETKLTLVFEHV--DQDLTTYLDKVPEPGVPTETI 122 + HP V+RL D + + LV E QDL D + E G E Sbjct: 89 WKVGAGGGHPGVIRLLD-----WFETQEGFMLVLERPLPAQDL---FDYITEKGPLGEGP 140 Query: 123 KDMMF-QLLRGLDFLHSHRVVHRDLKPQNILV-TSSGQIKLADFGLARIYSFQMALTSVV 180 F Q++ + HS VVHRD+K +NIL+ G KL DFG + + T Sbjct: 141 SRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDE-PYTDFD 199 Query: 181 VTLWYRAPEVLLQSSY-ATPVDLWSVGCIFAEM 212 T Y PE + + Y A P +WS+G + +M Sbjct: 200 GTRVYSPPEWISRHQYHALPATVWSLGILLYDM 232 >2WTK-B nrPDB Length = 373 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 81/330 (24%), Positives = 134/330 (40%), Gaps = 51/330 (15%) Query: 13 YECVAEIGEG--AYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 YE + IG+G V AR K G +V ++R+ ++ M E+ V + Sbjct: 11 YELLTVIGKGFEDLMTVNLAR-YKPTGEYVTVRRINLEACSNEMVTFLQGELHVSK---L 66 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDL--TTYLDKVPEPGVPTETIKDMMFQ 128 F HPN+V + ++ + + + +DL T ++D G+ I ++ Sbjct: 67 FNHPNIVP-YRATFIADNELWVVTSFMAYGSAKDLICTHFMD-----GMNELAIAYILQG 120 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADF--GLARIYSFQ-------MALTSV 179 +L+ LD++H VHR +K +IL++ G++ L+ L+ I Q SV Sbjct: 121 VLKALDYIHHMGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSV 180 Query: 180 VVTLWYRAPEVLLQS--SYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGK------- 230 V W +PEVL Q+ Y D++SVG E+ F+ L + Sbjct: 181 KVLPWL-SPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVP 239 Query: 231 -ILDVIGLPGEE---DWPRDVA-----------LPRQAFHSKSAQPIEKFVTDIDELGKD 275 +LD +P EE R VA PR S P + Sbjct: 240 CLLDTSTIPAEELTMSPSRSVANSGLSDSLTTSTPRP---SNGDSPSHPYHRTFSPHFHH 296 Query: 276 LLLKCLTFNPAKRISAYSALSHPYFQDLER 305 + +CL NP R SA + L+H +F+ ++R Sbjct: 297 FVEQCLQRNPDARPSASTLLNHSFFKQIKR 326 >2H34-A nrPDB Length = 309 Score = 55.8 bits (133), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 59/213 (27%), Positives = 97/213 (45%), Gaps = 17/213 (7%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVR 78 +G G G V++A D R VALK + + P+ R R + P+VV Sbjct: 42 VGRGGMGDVYEAEDTVRE-RIVALKLMSETLSSD--PVFRTRMQREARTAGRLQEPHVVP 98 Query: 79 LFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLH 137 + D + + +L + ++ DL L + P P + ++ Q+ LD H Sbjct: 99 IHDFGEI-----DGQLYVDMRLINGVDLAAMLRR-QGPLAPPRAVA-IVRQIGSALDAAH 151 Query: 138 SHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQ--MALTSVVVTLWYRAPEVLLQSS 195 + HRD+KP+NILV++ L DFG+A + + L + V TL+Y APE +S Sbjct: 152 AAGATHRDVKPENILVSADDFAYLVDFGIASATTDEKLTQLGNTVGTLYYMAPERFSESH 211 Query: 196 YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQL 228 D++++ C+ E P ++G DQL Sbjct: 212 ATYRADIYALTCVLYECLTGSPPYQG----DQL 240 >4RC3-A nrPDB Length = 289 Score = 55.5 bits (132), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 74/314 (23%), Positives = 123/314 (39%), Gaps = 53/314 (16%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVR----VQTGEEGMPLSTIREVAVL 65 + QY+ +G G +G V+ + + VA+K V GE EV +L Sbjct: 11 ESQYQVGPLLGSGGFGSVYSGIRVSDN-LPVAIKHVEKDRISDWGELPNGTRVPMEVVLL 69 Query: 66 RHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD--QDLTTYLDKVPEPGVPTETI- 122 + + + V+RL D +R L+ E + QDL D + E G E + Sbjct: 70 KKVSS-GFSGVIRLLDW-----FERPDSFVLILERPEPVQDL---FDFITERGALQEELA 120 Query: 123 KDMMFQLLRGLDFLHSHRVVHRDLKPQNILVT-SSGQIKLADFGLARIYSFQMALTSVVV 181 + +Q+L + H+ V+HRD+K +NIL+ + G++KL DFG + T Sbjct: 121 RSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK-DTVYTDFDG 179 Query: 182 TLWYRAPEVLLQSSY-ATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGE 240 T Y PE + Y +WS+G + +M + I + Sbjct: 180 TRVYSPPEWIRYHRYHGRSAAVWSLGILLYDM------------------VCGDIPFEHD 221 Query: 241 EDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 E+ R RQ S+ + L+ CL P+ R + +HP+ Sbjct: 222 EEIIRGQVFFRQRVSSEC---------------QHLIRWCLALRPSDRPTFEEIQNHPWM 266 Query: 301 QDLERCKENLDSHL 314 QD+ +E + HL Sbjct: 267 QDVLLPQETAEIHL 280 >3BGP-A nrPDB Length = 333 Score = 55.5 bits (132), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 76/315 (24%), Positives = 127/315 (40%), Gaps = 55/315 (17%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRV---RVQTGEEGMPLST--IREVAV 64 + QY+ +G G +G V+ + + VA+K V R+ E +P T EV + Sbjct: 55 ESQYQVGPLLGSGGFGSVYSGIRVSDN-LPVAIKHVEKDRISDWGE-LPNGTRVPMEVVL 112 Query: 65 LRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD--QDLTTYLDKVPEPGVPTETI 122 L+ + + V+RL D +R L+ E + QDL D + E G E + Sbjct: 113 LKKVSS-GFSGVIRLLDW-----FERPDSFVLILERPEPVQDL---FDFITERGALQEEL 163 Query: 123 -KDMMFQLLRGLDFLHSHRVVHRDLKPQNILV-TSSGQIKLADFGLARIYSFQMALTSVV 180 + +Q+L + H+ V+HRD+K +NIL+ + G++KL DFG + T Sbjct: 164 ARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK-DTVYTDFD 222 Query: 181 VTLWYRAPEVLLQSSY-ATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPG 239 T Y PE + Y +WS+G + +M + I Sbjct: 223 GTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDM------------------VCGDIPFEH 264 Query: 240 EEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPY 299 +E+ R RQ S+ + L+ CL P+ R + +HP+ Sbjct: 265 DEEIIRGQVFFRQRVSSEC---------------QHLIRWCLALRPSDRPTFEEIQNHPW 309 Query: 300 FQDLERCKENLDSHL 314 QD+ +E + HL Sbjct: 310 MQDVLLPQETAEIHL 324 >5TUR-A nrPDB Length = 404 Score = 54.7 bits (130), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 77/315 (24%), Positives = 127/315 (40%), Gaps = 55/315 (17%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRV---RVQT-GEEGMPLSTIREVAVL 65 + QY+ +G G +G V+ + + VA+K V R+ GE EV +L Sbjct: 126 ESQYQVGPLLGSGGFGSVYSGIRVSDN-LPVAIKHVEKDRISDWGELPNGTRVPMEVVLL 184 Query: 66 RHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD--QDLTTYLDKVPEPGVPTETI- 122 + + + V+RL D +R L+ E + QDL D + E G E + Sbjct: 185 KKVSS-GFSGVIRLLDW-----FERPDSFVLILERPEPVQDL---FDFITERGALQEELA 235 Query: 123 KDMMFQLLRGLDFLHSHRVVHRDLKPQNILVT-SSGQIKLADFGLARIYSFQMALTSVVV 181 + +Q+L + H+ V+HRD+K +NIL+ + G++KL DFG + T Sbjct: 236 RSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK-DTVYTDFDG 294 Query: 182 TLWYRAPEVLLQSSY-ATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIG-LPG 239 T Y PE + Y +WS+G + +M V G +P Sbjct: 295 TRVYSPPEWIRYHRYHGRSAAVWSLGILLYDM---------------------VCGDIPF 333 Query: 240 EEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPY 299 E D + + Q F F + + L+ CL P+ R + +HP+ Sbjct: 334 EHD---EEIIRGQVF----------FRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPW 380 Query: 300 FQDLERCKENLDSHL 314 QD+ +E + HL Sbjct: 381 MQDVLLPQETAEIHL 395 >4BTK-A nrPDB Length = 337 Score = 54.7 bits (130), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 57/232 (24%), Positives = 98/232 (42%), Gaps = 25/232 (10%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETF 71 +++ + +IG G +G++++A DL VALK Q ++ + + EVAVL+ L+ Sbjct: 57 RWKVLKKIGGGGFGEIYEAMDLLTREN-VALKVESAQQPKQVLKM----EVAVLKKLQGK 111 Query: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPGVPTETIKDMMFQLL 130 +H VC R K V + ++L P T + Q+L Sbjct: 112 DH--------VCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQIL 163 Query: 131 RGLDFLHSHRVVHRDLKPQNI----LVTSSGQIKLADFGLARIYSFQMA-------LTSV 179 ++ +HS +HRD+KP N L ++ + + DFGLAR Y+ + Sbjct: 164 ESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGF 223 Query: 180 VVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKI 231 T+ Y + DLWS+ + E + +R D +Q+G I Sbjct: 224 RGTVRYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMI 275 >4NFN-A nrPDB Length = 309 Score = 54.3 bits (129), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 57/232 (24%), Positives = 98/232 (42%), Gaps = 25/232 (10%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETF 71 +++ + +IG G +G++++A DL VALK Q ++ + + EVAVL+ L+ Sbjct: 22 RWKVLKKIGGGGFGEIYEAMDLLTREN-VALKVESAQQPKQVLKM----EVAVLKKLQGK 76 Query: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPGVPTETIKDMMFQLL 130 +H VC R K V + ++L P T + Q+L Sbjct: 77 DH--------VCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQIL 128 Query: 131 RGLDFLHSHRVVHRDLKPQNI----LVTSSGQIKLADFGLARIYSFQMA-------LTSV 179 ++ +HS +HRD+KP N L ++ + + DFGLAR Y+ + Sbjct: 129 ESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGF 188 Query: 180 VVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKI 231 T+ Y + DLWS+ + E + +R D +Q+G I Sbjct: 189 RGTVRYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMI 240 >5WNL-A nrPDB Length = 342 Score = 54.3 bits (129), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 54/227 (23%), Positives = 113/227 (49%), Gaps = 43/227 (18%) Query: 18 EIGEGAYGKVFKARDLKNGGRFVALK---------RVRVQTGEEGMPLSTIREVAVLRHL 68 ++G G +G+V+K R + + ++A+K R R++ EE + E+A R+ Sbjct: 27 KVGSGGFGQVYKVRHV-HWKTWLAIKCSPSLHVDDRERMELLEEAKKM----EMAKFRY- 80 Query: 69 ETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKV--PEPGVPTETIKDMM 126 ++ ++ +C + + LV E+++ T L+K+ EP +P + ++ Sbjct: 81 -------ILPVYGIC-------QEPVGLVMEYME---TGSLEKLLASEP-LPWDLRFRIV 122 Query: 127 FQLLRGLDFLH--SHRVVHRDLKPQNILVTSSGQIKLADFGLARI----YSFQMALTSVV 180 + G++FLH S ++H +LKP NIL+ + +K++DFGLA+ +S +++ + Sbjct: 123 HETAVGMNFLHCMSPPLLHLNLKPANILLDAHYHVKISDFGLAKCNGMSHSHDLSMDGLF 182 Query: 181 VTLWYRAPEVLLQSS--YATPVDLWSVGCIFAEMFRRKPLFRGSSDV 225 T+ Y PE + + S + T D++S + + +K F ++ Sbjct: 183 GTIAYLPPERIREKSRLFDTKHDVYSFAIVIWGVLTQKKPFADEKNI 229 >5E8V-A nrPDB Length = 316 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 57/222 (25%), Positives = 98/222 (44%), Gaps = 36/222 (16%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVR 78 +G+G + +V+KA+ +N V++ EE T +++ +L+ H N+++ Sbjct: 17 VGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLK---HENILQ 73 Query: 79 LFDVCTVSRTDRETKLTLVFE-----HVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGL 133 ++ +R+T+L + H +L YL + + E ++ + L RG+ Sbjct: 74 F-----LTAEERKTELGKQYWLITAFHAKGNLQEYLTR---HVISWEDLRKLGSSLARGI 125 Query: 134 DFLHSHR---------VVHRDLKPQNILVTSSGQIKLADFGLA-----RIYSFQMALTSV 179 LHS +VHRDLK NILV + L DFGL+ + +A + Sbjct: 126 AHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQ 185 Query: 180 VVTLWYRAPEVLLQSSYATPV------DLWSVGCIFAEMFRR 215 V T Y APEVL + V D++S+ + EM R Sbjct: 186 VGTARYMAPEVLASAMNLENVESFKQTDVYSMALVLWEMTSR 227 >6BFN-A nrPDB Length = 342 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 57/208 (27%), Positives = 84/208 (40%), Gaps = 22/208 (10%) Query: 18 EIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEE--GMPLSTIREVAVLRHLETFEHPN 75 +IGEG +G V++A ++N A+KR++ E + S + EV L F HPN Sbjct: 29 KIGEGGFGCVYRA-VMRN--TVYAVKRLKENADLEWTAVKQSFLTEV---EQLSRFRHPN 82 Query: 76 VVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDF 135 +V C + L ++ L P P D++ R + F Sbjct: 83 IVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRL--DILLGTARAIQF 140 Query: 136 LH--SHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTS----------VVVTL 183 LH S ++H D+K N+L+ KL DFGLAR F + S V TL Sbjct: 141 LHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTL 200 Query: 184 WYRAPEVLLQSSYATPVDLWSVGCIFAE 211 Y E + A D +S G + E Sbjct: 201 AYLPEEYIKTGRLAVDTDTFSFGVVVLE 228 >4M69-B nrPDB Length = 283 Score = 52.0 bits (123), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 53/234 (22%), Positives = 105/234 (44%), Gaps = 36/234 (15%) Query: 65 LRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPGVPTETIK 123 ++ ++ F+ PN++R+F +C + +T + + ++V E+ + L LD+ + + ++ Sbjct: 59 IKTMKKFDSPNILRIFGIC-IDQTVKPPEFSIVMEYCELGTLRELLDREKDLTMSVRSL- 116 Query: 124 DMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY-SFQMALTSVVV- 181 ++ + RGL LH +HR++ + LV Q+KLA F L++ S S Sbjct: 117 -LVLRAARGLYRLHHSETLHRNISSSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAE 175 Query: 182 ---TLWYRAPEVLLQ--SSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIG 236 + Y +PE L Y +++S G + E+ K F G KI +++ Sbjct: 176 RSSSTIYVSPERLKNPFCLYDIKAEIYSFGIVLWEIATGKIPFEGCDS----KKIRELVA 231 Query: 237 LPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRIS 290 ED K +P+ + D EL ++++ +C P++R S Sbjct: 232 ----ED--------------KKQEPVGQ---DCPELLREIINECRAHEPSQRPS 264 >4BTF-A nrPDB Length = 469 Score = 52.0 bits (123), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 40/168 (23%), Positives = 81/168 (48%), Gaps = 17/168 (10%) Query: 65 LRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPGVPTETIK 123 ++ ++ F+ PN++R+F +C + +T + + ++V E+ + L LD+ + + ++ Sbjct: 245 IKTMKKFDSPNILRIFGIC-IDQTVKPPEFSIVMEYCELGTLRELLDREKDLTMSVRSL- 302 Query: 124 DMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY--------SFQMA 175 ++ + RGL LH +HR++ + LV Q+KLA F L++ S + Sbjct: 303 -LVLRAARGLYRLHHSETLHRNISSSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAE 361 Query: 176 LTSVVVTLWYRAPEVLLQ--SSYATPVDLWSVGCIFAEMFRRKPLFRG 221 +S + Y +PE L Y +++S G + E+ K F G Sbjct: 362 RSSSTI---YVSPERLKNPFCLYDIKAEIYSFGIVLWEIATGKIPFEG 406 >1PY5-A nrPDB Length = 326 Score = 52.0 bits (123), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 61/217 (28%), Positives = 92/217 (42%), Gaps = 33/217 (15%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVR 78 IG+G +G+V++ K G VA+K + + I + +LRH N++ Sbjct: 37 IGKGRFGEVWRG---KWRGEEVAVKIFSSREERSWFREAEIYQTVMLRH------ENILG 87 Query: 79 LFDVCTVSRTDRETKLTLVFE-HVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLH 137 F T+L LV + H L YL++ V E + + GL LH Sbjct: 88 -FIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYT---VTVEGMIKLALSTASGLAHLH 143 Query: 138 SH--------RVVHRDLKPQNILVTSSGQIKLADFGLARIY-----SFQMALTSVVVTLW 184 + HRDLK +NILV +G +AD GLA + + +A V T Sbjct: 144 MEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKR 203 Query: 185 YRAPEVLLQS------SYATPVDLWSVGCIFAEMFRR 215 Y APEVL S D++++G +F E+ RR Sbjct: 204 YMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARR 240 >5OAT-A nrPDB Length = 411 Score = 51.6 bits (122), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 55/198 (27%), Positives = 83/198 (41%), Gaps = 34/198 (17%) Query: 73 HPNVVRLFDVCT------------VSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTE 120 HPN+V +F V T R L L+ + D +L ++L P T Sbjct: 98 HPNIVAIFSVFTDLYPAALPPRLHPEGEGRNMSLFLLMKRYDCNLQSFLSTAPS----TR 153 Query: 121 TIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQ----IKLADFGLA---RIYSFQ 173 T ++ QLL G+ + +H + HRDLK N+L+ +S + ++DFG + Sbjct: 154 TSLLLLAQLLEGVAHMTAHGIAHRDLKSDNLLLDTSEPESPILVISDFGCCLADKTNGLS 213 Query: 174 MALTSVVV----TLWYRAPEVLLQSSYATPV------DLWSVGCIFAEMFRRKPLFRGSS 223 + TS + APE++ Q V DLW+VG I E+F F G S Sbjct: 214 LPYTSYEMDKGGNTALMAPEIICQKPGTFSVLNYSKADLWAVGAIAYEIFNCHNPFYGPS 273 Query: 224 DVDQLG-KILDVIGLPGE 240 + K D+ LP E Sbjct: 274 RLKNFNYKEGDLPKLPDE 291 >4CYJ-A nrPDB Length = 438 Score = 51.2 bits (121), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 44/166 (26%), Positives = 80/166 (48%), Gaps = 22/166 (13%) Query: 27 VFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREV-AVLRHLETFEHPNVVRLFDVCTV 85 V+KA++ +NG R AL+R+ EG L+ + + V++ + ++ ++V + +V T Sbjct: 71 VYKAQNSRNG-RHYALRRL------EGYRLTNEKAILNVMKDWKKIKNASIVTIHEVFT- 122 Query: 86 SRTDRETKLTLVFEHVDQDLTTYLDK-----------VPEPGVPTETIKDMMFQLLRGLD 134 T +L+F + L+ L + P P VP TI + Q+ L Sbjct: 123 --TREFGDSSLIFAYDFHPLSKTLQEHHFQPIHGNRYRPPPAVPENTIWGYICQIANALK 180 Query: 135 FLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVV 180 +HS+R+ R L+P I++T +I+L+ + + F M SVV Sbjct: 181 TIHSNRLAARCLEPSKIILTDINRIRLSACAILDVVQFGMNSRSVV 226 >5VDK-A nrPDB Length = 297 Score = 50.8 bits (120), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 39/151 (25%), Positives = 73/151 (48%), Gaps = 15/151 (9%) Query: 8 RADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQT--GEEGMPLSTIREVAVL 65 R ++++ V +IG G +G V+K +G + + ++ T E L + AVL Sbjct: 12 RYEKEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSALHEVYAHAVL 71 Query: 66 RHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTE--TI 122 H HP+VVR + S + + + E+ + L + + + G E + Sbjct: 72 GH-----HPHVVRYY-----SSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKL 121 Query: 123 KDMMFQLLRGLDFLHSHRVVHRDLKPQNILV 153 KD++ Q+ GL+++H+ +VH D+KP NI + Sbjct: 122 KDILLQISLGLNYIHNSSMVHLDIKPSNIFI 152 >3M42-A nrPDB Length = 299 Score = 50.4 bits (119), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 52/205 (25%), Positives = 89/205 (43%), Gaps = 36/205 (17%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVR 78 +G G GKV + + + +F ALK + + P + REV + H + P++VR Sbjct: 26 LGLGINGKVLQIFNKRTQEKF-ALKML------QDCPKAR-REVEL--HWRASQCPHIVR 75 Query: 79 LFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLH 137 + DV R+ L +V E +D +L + + + ++M + + +LH Sbjct: 76 IVDVYENLYAGRKC-LLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 134 Query: 138 SHRVVHRDLKPQNILVTS---SGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQS 194 S + HRD+KP+N+L TS + +KL DFG A+ + + Sbjct: 135 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTGE--------------------- 173 Query: 195 SYATPVDLWSVGCIFAEMFRRKPLF 219 Y D+WS+G I + P F Sbjct: 174 KYDKSCDMWSLGVIMYILLCGYPPF 198 >4F0G-A nrPDB Length = 287 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 53/215 (24%), Positives = 97/215 (45%), Gaps = 27/215 (12%) Query: 9 ADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPL-----STIREVA 63 AD + E +IG+G +G V K R +K+ VA+K + + E + REV Sbjct: 17 ADNEIEYEKQIGKGGFGLVHKGRLVKDKS-VVAIKSLILGDSEGETEMIEKFQEFQREVF 75 Query: 64 VLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIK 123 ++ +L HPN+V+L+ + ++ + F LDK P + Sbjct: 76 IMSNLN---HPNIVKLYGL-----MHNPPRMVMEFVPCGDLYHRLLDKA-HP-IKWSVKL 125 Query: 124 DMMFQLLRGLDFLHSHR--VVHRDLKPQNILVTSSGQ-----IKLADFGLARIYSFQMAL 176 +M + G++++ + +VHRDL+ NI + S + K+ADFGL++ ++ Sbjct: 126 RLMLDIALGIEYMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQ--QSVHSV 183 Query: 177 TSVVVTLWYRAPEVL--LQSSYATPVDLWSVGCIF 209 + ++ + APE + + SY D +S I Sbjct: 184 SGLLGNFQWMAPETIGAEEESYTEKADTYSFAMIL 218 >2Y4I-B nrPDB Length = 319 Score = 50.1 bits (118), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 54/233 (23%), Positives = 99/233 (42%), Gaps = 44/233 (18%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 +Q E IG+G +G+V+ R VA++ + ++ E + REV R Sbjct: 33 EQLEIGELIGKGRFGQVYHGRWHGE----VAIRLIDIERDNEDQLKAFKREVMAYRQTR- 87 Query: 71 FEHPNVVRLFDVCT--------VSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETI 122 H NVV C S T ++V +D LD Sbjct: 88 --HENVVLFMGACMSPPHLAIITSLCKGRTLYSVV-----RDAKIVLD--------VNKT 132 Query: 123 KDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMA------L 176 + + ++++G+ +LH+ ++H+DLK +N+ +G++ + DFGL I A L Sbjct: 133 RQIAQEIVKGMGYLHAKGILHKDLKSKNVFY-DNGKVVITDFGLFSISGVLQAGRREDKL 191 Query: 177 TSVVVTLWYRAPEVLLQSS---------YATPVDLWSVGCIFAEMFRRKPLFR 220 L + APE++ Q S ++ D++++G I+ E+ R+ F+ Sbjct: 192 RIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFK 244 >3MY0-A nrPDB Length = 305 Score = 48.5 bits (114), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 74/303 (24%), Positives = 123/303 (40%), Gaps = 42/303 (13%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 +Q V +G+G YG+V+ R L +G VA+K + + + I +LRH Sbjct: 8 RQVALVECVGKGRYGEVW--RGLWHG-ESVAVKIFSSRDEQSWFRETEIYNTVLLRH--- 61 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDK-VPEPGVPTETIKDMMFQL 129 N++ SR + H L +L + EP + + Sbjct: 62 ---DNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALR----LAVSA 114 Query: 130 LRGLDFLHSH--------RVVHRDLKPQNILVTSSGQIKLADFGLARIYS-----FQMAL 176 GL LH + HRD K +N+LV S+ Q +AD GLA ++S + Sbjct: 115 ACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGN 174 Query: 177 TSVVVTLWYRAPEVLLQS-------SYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLG 229 V T Y APEVL + SY D+W+ G + E+ RR + G + D Sbjct: 175 NPRVGTKRYMAPEVLDEQIRTDCFESYKW-TDIWAFGLVLWEIARRT-IVNGIVE-DYRP 231 Query: 230 KILDVI-GLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKR 288 DV+ P ED + V + +Q + + ++ + ++ ++ C NP+ R Sbjct: 232 PFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRE----CWYPNPSAR 287 Query: 289 ISA 291 ++A Sbjct: 288 LTA 290 >5VC6-A nrPDB Length = 289 Score = 48.1 bits (113), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 39/152 (25%), Positives = 69/152 (45%), Gaps = 15/152 (9%) Query: 8 RADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRH 67 R ++ + +IG G +G VFK +G + A+KR + + +REV H Sbjct: 8 RYTTEFHELEKIGSGEFGSVFKCVKRLDGCIY-AIKRSKKPLAGSVDEQNALREVYA--H 64 Query: 68 LETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPE-----PGVPTETI 122 +H +VVR F + + + E+ + + D + E + Sbjct: 65 AVLGQHSHVVRYFSAWA-----EDDHMLIQNEYCNGG--SLADAISENYRIMSYFKEAEL 117 Query: 123 KDMMFQLLRGLDFLHSHRVVHRDLKPQNILVT 154 KD++ Q+ RGL ++HS +VH D+KP NI ++ Sbjct: 118 KDLLLQVGRGLRYIHSMSLVHMDIKPSNIFIS 149 >5UV4-A nrPDB Length = 311 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 55/212 (25%), Positives = 96/212 (45%), Gaps = 28/212 (13%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVR 78 IG +G +KA L NG + V+ +EG S ++ L + HPN+V Sbjct: 33 IGRSCHGTSYKAT-LDNG------YMLTVKWLKEGFAKSKKEFSREIKKLGSVRHPNLVP 85 Query: 79 LFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIK---DMMFQLLRGLD 134 L +E + ++ ++ D L+TYL + E +P + ++ + R LD Sbjct: 86 LRGY---YWGPKEHERIMISDYADATSLSTYLSEFDERNLPPLSAGQRLNIAIDIARCLD 142 Query: 135 FLHSHRVV-HRDLKPQNILVTSSGQIKL-ADFGLARIYSFQMALTSVVVT---LWYRAPE 189 +LH+ RV+ H ++K N+L+ +S L D+ L R+ + + + V+ L Y PE Sbjct: 143 YLHNERVIPHGNIKSSNVLIQNSTPSALVTDYSLHRLMT-PIGMAEQVLNAGALGYSPPE 201 Query: 190 VLLQSSYATPV-----DLWSVGCIFAEMFRRK 216 SS + P D+++ G I E+ K Sbjct: 202 F---SSTSKPCPSLKSDVYAFGVILLELLTGK 230 >4M66-A nrPDB Length = 325 Score = 46.6 bits (109), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 58/206 (28%), Positives = 94/206 (45%), Gaps = 34/206 (16%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVR 78 +G+G +G VF+A + VA+K V + EV + +L + NV+ Sbjct: 28 VGKGGFGVVFRAHH-RTWNHDVAVKIVNSK--------KISWEVKAMVNLR---NENVLL 75 Query: 79 LFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHS 138 L V + D + LV ++ L + PE P + ++ +++ G+ +LHS Sbjct: 76 LLGVTEDLQWDFVSGQALVTRFMENGSLAGLLQ-PEAPRPWPLLCRLLQEVVLGMCYLHS 134 Query: 139 --HRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQ----------MALTSVVVTLWYR 186 ++HRDLKP NIL+ KLADFGL+ +FQ TL Y Sbjct: 135 LDPPLLHRDLKPSNILLDPELHAKLADFGLS---TFQGGSQSGSGSGSGSRDSGGTLAYL 191 Query: 187 APEVL----LQSSYATPVDLWSVGCI 208 PE+L L++S A+ D++S G + Sbjct: 192 DPELLFKVNLKASKAS--DVYSFGIL 215 >4JRN-A nrPDB Length = 372 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 27/91 (29%), Positives = 46/91 (50%), Gaps = 10/91 (10%) Query: 128 QLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRA 187 Q ++ + + + +VH D+KP N L+ G++ L DFG RI + ++ + T Y Sbjct: 210 QAIKLVANVQAQGIVHTDIKPANFLLLKDGRLFLGDFGTYRINN---SVGRAIGTPGYEP 266 Query: 188 PEVLLQS---SYATPVDLWSVG----CIFAE 211 PE Q+ +Y P D W +G CI+ + Sbjct: 267 PERPFQATGITYTFPTDAWQLGITLYCIWCK 297 >4MWI-A nrPDB Length = 294 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 43/171 (25%), Positives = 80/171 (46%), Gaps = 15/171 (8%) Query: 65 LRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPGVPTETIK 123 ++ ++ FE PN++R+F +C + T + ++V E+ + L LD+ + + + Sbjct: 74 IKTMKKFESPNILRIFGIC-IDETVTPPQFSIVMEYCELGTLRELLDREKDLTLGKRMV- 131 Query: 124 DMMFQLLRGLDFLHSHRV--VHRDLKPQNILVTSSGQIKLADFGLARIYSFQMAL----- 176 ++ RGL LH +H ++ N LVT Q+KLA F L + + M+L Sbjct: 132 -LVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQVKLAGFELRKTQT-SMSLGTTRE 189 Query: 177 -TSVVVTLWYRAPEVLLQSSYATPV--DLWSVGCIFAEMFRRKPLFRGSSD 224 T V + Y +P+ L Y V +++S G + E+ F+G + Sbjct: 190 KTDRVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNS 240 >5M07-A nrPDB Length = 276 Score = 45.8 bits (107), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 37/140 (26%), Positives = 67/140 (47%), Gaps = 28/140 (20%) Query: 73 HPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYL-DKVPEPGVPTETIKDMMFQLL 130 HP+++ + D R + + +L + ++VD D T ++ D+ P +P + ++ + Sbjct: 89 HPHILEVHD-----RGEFDGQLWIAMDYVDGIDATQHMADRFPAV-LPVGEVLAIVTAVA 142 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTSSG----QIKLADFGLARIYSF-------------- 172 LD+ H ++HRD+ P N+++TS +I LADFG+A S+ Sbjct: 143 GALDYAHQRGLLHRDVNPANVVLTSQSAGDQRILLADFGIASQPSYPAPELSAGADVDGR 202 Query: 173 --QMALTSVVVTLWYRAPEV 190 Q AL + L+ AP V Sbjct: 203 ADQYALALTAIHLFAGAPPV 222 >3SV0-A nrPDB Length = 483 Score = 45.1 bits (105), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 39/166 (23%), Positives = 77/166 (46%), Gaps = 16/166 (9%) Query: 8 RADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRH 67 R ++ +IG G++G+++ +++ VA+K V+T + + E + R Sbjct: 4 RVGNKFRLGRKIGSGSFGEIYLGTNIQTNEE-VAIKLENVKTKHPQL----LYESKIYRI 58 Query: 68 LETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMF 127 L+ VR F V D + + +DL + + + +T+ + Sbjct: 59 LQGGTGIPNVRWFGV----EGDYNVLVMDLLGPSLEDLFNFCSRK----LSLKTVLMLAD 110 Query: 128 QLLRGLDFLHSHRVVHRDLKPQNILVT---SSGQIKLADFGLARIY 170 Q++ ++F+HS +HRD+KP N L+ + Q+ + DFGLA+ Y Sbjct: 111 QMINRVEFVHSKSFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKY 156 >2CMW-A nrPDB Length = 310 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 20/56 (35%), Positives = 35/56 (62%), Gaps = 5/56 (8%) Query: 120 ETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQ-----IKLADFGLARIY 170 +T+ + QLL ++++HS +++RD+KP+N L+ G I + DFGLA+ Y Sbjct: 97 KTVLMIAIQLLSRMEYVHSKNLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEY 152 >4LQP-A nrPDB Length = 508 Score = 43.5 bits (101), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 44/158 (27%), Positives = 76/158 (48%), Gaps = 11/158 (6%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 + + V IG+GA+G+V + K+ G+ A+K + + L+ ++ A L Sbjct: 102 EDFHTVKVIGKGAFGEV-RLVQKKDTGKIYAMKTLLKSEMYKKDQLAHVK--AERDVLAG 158 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPGVPTETIKDMMFQL 129 + P VV L+ S D + L L+ E + DL T L + + + M + Sbjct: 159 SDSPWVVSLY----YSFQDAQY-LYLIMEFLPGGDLMTML--IRWQLFTEDVTRFYMAEC 211 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLA 167 + ++ +H +HR +KP NIL+ G IKL+DFGL+ Sbjct: 212 ILAIETIHKLGFIHRAIKPDNILIDIRGHIKLSDFGLS 249 Score = 33.5 bits (75), Expect = 0.13, Method: Compositional matrix adjust. Identities = 19/56 (33%), Positives = 25/56 (44%) Query: 178 SVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILD 233 S V T Y APE+ L Y D WS+G I E P F + + KI++ Sbjct: 322 STVGTPDYIAPEIFLYQGYGQECDWWSLGAIMYECLIGWPPFCSETPQETYRKIMN 377 >5X18-A nrPDB Length = 295 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 38/181 (20%), Positives = 71/181 (39%), Gaps = 52/181 (28%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFV---------------ALKRVRVQTGEEGMPL 56 Y+ +IGEG++G +F+ ++ NG K ++ G +P Sbjct: 8 HYKIGKKIGEGSFGVLFEGTNMINGVPVAIKFEPRKTEAPQLRDEYKTYKILNGTPNIPY 67 Query: 57 STIREVAVLRHLETFE--HPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPE 114 + L ++ + P++ LFD C + Sbjct: 68 AYYFGQEGLHNILVIDLLGPSLEDLFDWCGRKFS-------------------------- 101 Query: 115 PGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQ-----IKLADFGLARI 169 +T+ + Q++ ++ LH+H +++RD+KP N L+ GQ I L DFG+A+ Sbjct: 102 ----VKTVVQVAVQMITLIEDLHAHDLIYRDIKPDNFLIGRPGQPDANNIHLIDFGMAKQ 157 Query: 170 Y 170 Y Sbjct: 158 Y 158 >2QLU-A nrPDB Length = 314 Score = 42.4 bits (98), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 56/223 (25%), Positives = 90/223 (40%), Gaps = 33/223 (14%) Query: 22 GAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFD 81 G +G V+KA+ + + FVA+K +Q + I ++H + F Sbjct: 26 GRFGCVWKAQLMND---FVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQ-------FI 75 Query: 82 VCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLH--- 137 ++ E +L L+ D+ LT YL + + + + RGL +LH Sbjct: 76 AAEKRGSNLEVELWLITAFHDKGSLTDYLKGNI---ITWNELCHVAETMSRGLSYLHEDV 132 Query: 138 ------SHR--VVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSV---VVTLWYR 186 H+ + HRD K +N+L+ S LADFGLA + V T Y Sbjct: 133 PWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVGTRRYM 192 Query: 187 APEVL-----LQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSD 224 APEVL Q +D++++G + E+ R G D Sbjct: 193 APEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVD 235 >5AR8-A nrPDB Length = 326 Score = 42.0 bits (97), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 64/267 (23%), Positives = 112/267 (41%), Gaps = 28/267 (10%) Query: 1 MEKDGLCRA--DQQYECVAEI---GEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMP 55 M + +C A Y +A++ GA G V AR + VA+K + + T P Sbjct: 17 MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARH-ADWRVQVAVKHLHIHT-----P 70 Query: 56 LSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPE 114 L VLR E + + + + L +V E++ + L L + E Sbjct: 71 LLDSERKDVLREAEILHKARFSYILPILGI--CNEPEFLGIVTEYMPNGSLNELLHRKTE 128 Query: 115 -PGVPTETIKDMMFQLLRGLDFLHSHR--VVHRDLKPQNILVTSSGQIKLADFGLARIYS 171 P V ++ ++ G+++LH+ ++H DLK QNIL+ + +K+ADFGL++ Sbjct: 129 YPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRM 188 Query: 172 FQMALTSVVV------TLWYRAPEVL---LQSSYATPVDLWSVGCIFAEMFRRKPLFRGS 222 ++ + T+ Y PE +S + D++S I E+ RK F Sbjct: 189 MSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDV 248 Query: 223 SDVDQLGKILDVIGLP--GEEDWPRDV 247 ++ Q+ + P EE P D+ Sbjct: 249 TNPLQIMYSVSQGHRPVINEESLPYDI 275 >3SOC-A nrPDB Length = 322 Score = 41.6 bits (96), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 33/114 (28%), Positives = 53/114 (46%), Gaps = 18/114 (15%) Query: 129 LLRGLDFLH--------SHR--VVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTS 178 + RGL +LH H+ + HRD+K +N+L+ ++ +ADFGLA + + Sbjct: 130 MARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGD 189 Query: 179 V---VVTLWYRAPEVL-----LQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSD 224 V T Y APEVL Q +D++++G + E+ R G D Sbjct: 190 THGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVD 243 >2C47-A nrPDB Length = 313 Score = 41.2 bits (95), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 19/56 (33%), Positives = 35/56 (62%), Gaps = 5/56 (8%) Query: 120 ETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSG-----QIKLADFGLARIY 170 +T+ + QL+ ++++H+ +++RD+KP+N LV G I + DFGLA+ Y Sbjct: 100 KTVLMIAIQLITRMEYVHTKSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEY 155 >4NT4-A nrPDB Length = 312 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 20/48 (41%), Positives = 34/48 (70%), Gaps = 5/48 (10%) Query: 128 QLLRGLDFLHSHRVVHRDLKPQNILV--TSSGQ---IKLADFGLARIY 170 QLL ++++HS +++RD+KP+N L+ TS+ + I + DFGLA+ Y Sbjct: 122 QLLHRIEYVHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEY 169 >4TN6-A nrPDB Length = 318 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 44/188 (23%), Positives = 74/188 (39%), Gaps = 60/188 (31%) Query: 8 RADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTG--------------EEG 53 R +Y +IG G++G ++ D+ G VA+K V+T + G Sbjct: 4 RVGNRYRLGRKIGSGSFGDIYLGTDIA-AGEEVAIKLECVKTKHPQLHIESKIYKMMQGG 62 Query: 54 MPLSTIR--------EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDL 105 + + TIR V V+ L P++ LF+ C+ R+ L V DQ Sbjct: 63 VGIPTIRWCGAEGDYNVMVMELLG----PSLEDLFNFCS-----RKFSLKTVLLLADQ-- 111 Query: 106 TTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILV---TSSGQIKLA 162 ++ ++++HS +HRD+KP N L+ + + Sbjct: 112 -----------------------MISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYII 148 Query: 163 DFGLARIY 170 DFGLA+ Y Sbjct: 149 DFGLAKKY 156 >2CHL-A nrPDB Length = 351 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 18/56 (32%), Positives = 34/56 (60%), Gaps = 5/56 (8%) Query: 120 ETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQ-----IKLADFGLARIY 170 +T+ + QL+ ++++HS +++RD+KP+N L+ G I + DF LA+ Y Sbjct: 126 KTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEY 181 >4O1O-A nrPDB Length = 717 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 18/50 (36%), Positives = 28/50 (56%) Query: 115 PGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADF 164 P E+ ++++ L + + LH H+DL+PQNIL+ S LADF Sbjct: 437 PNEEDESARNILSSLFKAIGELHRSGYSHQDLQPQNILIDSKNGTFLADF 486 >5L2Q-C nrPDB Length = 320 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 26/99 (26%), Positives = 53/99 (53%), Gaps = 4/99 (4%) Query: 125 MMFQLLRGLDFLHSHRVVHRDLKPQNILVTS-SGQIKLADFGLAR-IYSFQMALTSVVVT 182 + + ++R ++ LH +VHRDLK N+++ + +I + +F L + + S L + Sbjct: 158 IFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEGDLLKDQRGS 217 Query: 183 LWYRAPEVLLQSSY-ATPVDLWSVGCI-FAEMFRRKPLF 219 Y +P+VL Y P D+W++G + F ++ + P + Sbjct: 218 PAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPFY 256 >4OAU-C nrPDB Length = 699 Score = 38.9 bits (89), Expect = 0.003, Method: Compositional matrix adjust. Identities = 44/149 (29%), Positives = 66/149 (44%), Gaps = 25/149 (16%) Query: 28 FKARDLKNGGRFVAL---KRVRVQTGEEGMPLSTIREVAVLR------HLETFEHPNVVR 78 +K D GG ++ + V V+T EG P + REV+ L+ HL TF R Sbjct: 349 YKIADTSEGGIYLGFYEKQEVAVKTFCEGSPRAQ-REVSCLQSSRENSHLVTFYGSESHR 407 Query: 79 --LFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFL 136 LF T+ E L + H +D+ D E ++++ + + + L Sbjct: 408 GHLFVCVTLCEQTLEACLDV---HRGEDVENEED---------EFARNVLSSIFKAVQEL 455 Query: 137 H-SHRVVHRDLKPQNILVTSSGQIKLADF 164 H S H+DL+PQNIL+ S LADF Sbjct: 456 HLSCGYTHQDLQPQNILIDSKKAAHLADF 484 >4IX6-A nrPDB Length = 350 Score = 38.9 bits (89), Expect = 0.003, Method: Compositional matrix adjust. Identities = 21/49 (42%), Positives = 27/49 (55%), Gaps = 2/49 (4%) Query: 123 KDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTS--SGQIKLADFGLARI 169 K M +LL L LH VVHRD+KP N++ G +KL D G A + Sbjct: 146 KKAMRELLGSLARLHECGVVHRDVKPANLIAAEKDGGVLKLIDLGAAAL 194 >5FQD-C nrPDB Length = 341 Score = 38.9 bits (89), Expect = 0.003, Method: Compositional matrix adjust. Identities = 40/170 (23%), Positives = 76/170 (44%), Gaps = 32/170 (18%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLR----- 66 +Y+ V +IG G++G ++ A ++ NG VA+K + Q L + +L+ Sbjct: 20 KYKLVRKIGSGSFGDIYLAINITNGEE-VAVK-LESQKARHPQLLYESKLYKILQGGVGI 77 Query: 67 -HLETF--EHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIK 123 H+ + E V + D+ S D +F + T +T+ Sbjct: 78 PHIRWYGQEKDYNVLVMDLLGPSLED-------LFNFCSRRFTM------------KTVL 118 Query: 124 DMMFQLLRGLDFLHSHRVVHRDLKPQNILVT---SSGQIKLADFGLARIY 170 + Q++ ++++H+ +HRD+KP N L+ ++ L DFGLA+ Y Sbjct: 119 MLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKY 168 >2RSV-A nrPDB Length = 403 Score = 38.9 bits (89), Expect = 0.003, Method: Compositional matrix adjust. Identities = 18/53 (33%), Positives = 31/53 (58%), Gaps = 2/53 (3%) Query: 120 ETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSG--QIKLADFGLARIY 170 +T+ + ++L L+++H H VH D+K N+L+ Q+ L D+GLA Y Sbjct: 159 KTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRY 211 >2JII-A nrPDB Length = 352 Score = 38.5 bits (88), Expect = 0.004, Method: Compositional matrix adjust. Identities = 23/77 (29%), Positives = 39/77 (50%), Gaps = 2/77 (2%) Query: 96 LVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILV-- 153 LV + + L + LD P+ + ++ + +LL L+FLH + VH ++ +NI V Sbjct: 135 LVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVDP 194 Query: 154 TSSGQIKLADFGLARIY 170 Q+ LA +G A Y Sbjct: 195 EDQSQVTLAGYGFAFRY 211 >2LAV-A nrPDB Length = 361 Score = 38.5 bits (88), Expect = 0.004, Method: Compositional matrix adjust. Identities = 18/53 (33%), Positives = 31/53 (58%), Gaps = 2/53 (3%) Query: 120 ETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSG--QIKLADFGLARIY 170 +T+ + ++L L+++H H VH D+K N+L+ Q+ L D+GLA Y Sbjct: 152 KTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRY 204 >5J0A-A nrPDB Length = 300 Score = 37.0 bits (84), Expect = 0.011, Method: Compositional matrix adjust. Identities = 37/159 (23%), Positives = 68/159 (42%), Gaps = 19/159 (11%) Query: 68 LETFEHPNVV--RLFDVCTVSRTDRETKLTLVFEHVDQ----DLTTYLDKVPEPGVPTET 121 L++ HPN+V R F + L L E+ + DL K + P Sbjct: 68 LKSLHHPNIVGYRAFTEAN------DGSLCLAMEYGGEKSLNDLIEERYKASQDPFPAAI 121 Query: 122 IKDMMFQLLRGLDFLHSH-RVVHRDLKPQNILVTSSGQ-IKLADFGLARIYSFQMALTS- 178 I + + RGL +LH +++H D+K N+++ + IK+ D G++ M +T Sbjct: 122 ILKVALNMARGLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMEVTDP 181 Query: 179 ---VVVTLWYRAPEVLLQSSYAT-PVDLWSVGCIFAEMF 213 + T ++ E + ++ T D+++ G EM Sbjct: 182 EACYIGTEPWKPKEAVEENGVITDKADIFAFGLTLWEMM 220 >6G4J-A nrPDB Length = 315 Score = 37.0 bits (84), Expect = 0.011, Method: Compositional matrix adjust. Identities = 46/156 (29%), Positives = 66/156 (42%), Gaps = 17/156 (10%) Query: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 Y ++G+GA G V+ A + +G VALK LS EV VL+ + Sbjct: 28 YTLRKQLGKGANGIVYLA-ETSDG--HVALK-------VSDDSLSITSEVNVLKSFSKAQ 77 Query: 73 HPNVV-RLFDVCTVSRTDRETKLTL-VFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130 + FD TK++ E++ L L V + G E I +M QLL Sbjct: 78 SVTMGPSFFDTDDAYIPSANTKVSFYAMEYIKGPL--LLKYVSDKGA--EWIPVLMIQLL 133 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTS-SGQIKLADFG 165 L LH + DLKP N++VT +I+ D G Sbjct: 134 SSLSVLHQQGWIFGDLKPDNLIVTGPPARIRCIDVG 169 >5CLR-A nrPDB Length = 451 Score = 36.2 bits (82), Expect = 0.023, Method: Compositional matrix adjust. Identities = 26/93 (27%), Positives = 45/93 (48%), Gaps = 5/93 (5%) Query: 125 MMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLW 184 +M + + H ++HRDLKP NI++ + Q L DFG + S + + T Sbjct: 181 IMISVCHQVKQFHELGLIHRDLKPGNIMLDADMQCHLVDFGSSS--SDKEPKPASWGTAS 238 Query: 185 YRAPEVLLQS---SYATPVDLWSVGCIFAEMFR 214 Y APE+ Q +++ DL+++ E+F Sbjct: 239 YLAPELNAQEDFIAFSQVSDLFALAYSLDELFN 271 >5UU1-A nrPDB Length = 324 Score = 35.4 bits (80), Expect = 0.033, Method: Compositional matrix adjust. Identities = 17/52 (32%), Positives = 32/52 (61%), Gaps = 2/52 (3%) Query: 121 TIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILV--TSSGQIKLADFGLARIY 170 T+ + ++L L+++H + VH D+K N+L+ + Q+ LAD+GL+ Y Sbjct: 131 TVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRY 182 >4XHH-A nrPDB Length = 403 Score = 35.0 bits (79), Expect = 0.043, Method: Compositional matrix adjust. Identities = 15/54 (27%), Positives = 30/54 (55%), Gaps = 3/54 (5%) Query: 120 ETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVT---SSGQIKLADFGLARIY 170 +T+ + Q++ + ++H +HRD+KP N L+ + + DFGL++ Y Sbjct: 103 KTVIMLALQMICRVQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKY 156 >3Q60-A nrPDB Length = 371 Score = 35.0 bits (79), Expect = 0.045, Method: Compositional matrix adjust. Identities = 45/187 (24%), Positives = 70/187 (37%), Gaps = 38/187 (20%) Query: 128 QLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRA 187 QL+R L S +VH P N+ + G++ L D + +SV VT A Sbjct: 202 QLIRLAANLQSKGLVHGHFTPDNLFIMPDGRLMLGDVSALWKVGTRGPASSVPVTY---A 258 Query: 188 PEVLLQSSYAT---PVDLWSVG-------CIFAEMFRRKPLFRGSSDVDQLGKILDVIGL 237 P L +S AT ++ W +G C+F P +GS L + Sbjct: 259 PREFLNASTATFTHALNAWQLGLSIYRVWCLFLPFGLVTPGIKGSWKRPSL-------RV 311 Query: 238 PGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSH 297 PG + + S P+ FV K L+ + L F+ +R+ A+ Sbjct: 312 PGTD-----------SLAFGSCTPLPDFV-------KTLIGRFLNFDRRRRLLPLEAMET 353 Query: 298 PYFQDLE 304 P F L+ Sbjct: 354 PEFLQLQ 360 >4XHL-A nrPDB Length = 394 Score = 34.7 bits (78), Expect = 0.051, Method: Compositional matrix adjust. Identities = 36/170 (21%), Positives = 74/170 (43%), Gaps = 24/170 (14%) Query: 8 RADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRH 67 R +++ +IG G++G ++ +L +G VA++ +++ + E V R+ Sbjct: 4 RVGRKFRIGRKIGSGSFGDIYHGTNLISGEE-VAIRLESIRSRHPQLDY----ESRVYRY 58 Query: 68 LETFEHPNVVRLFDVCTVSRTDRETKLT-LVFEHVD---QDLTTYLDKVPEPGVPTETIK 123 L +R F RE + +V + + +DL Y + +T+ Sbjct: 59 LSGGVGIPFIRWFG--------REGEYNAMVIDLLGPSLEDLFNYCHRR----FSFKTVI 106 Query: 124 DMMFQLLRGLDFLHSHRVVHRDLKPQNILV---TSSGQIKLADFGLARIY 170 + Q+ + ++H +HRD+KP N L+ + + DFGL++ Y Sbjct: 107 MLALQMFCRIQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKY 156 >1CSN-A nrPDB Length = 298 Score = 33.9 bits (76), Expect = 0.099, Method: Compositional matrix adjust. Identities = 15/48 (31%), Positives = 27/48 (56%), Gaps = 5/48 (10%) Query: 128 QLLRGLDFLHSHRVVHRDLKPQNILV-----TSSGQIKLADFGLARIY 170 Q+L + +H +V+RD+KP N L+ ++ I + DFG+ + Y Sbjct: 114 QMLARVQSIHEKSLVYRDIKPDNFLIGRPNSKNANMIYVVDFGMVKFY 161 >5X1R-A nrPDB Length = 302 Score = 33.9 bits (76), Expect = 0.11, Method: Compositional matrix adjust. Identities = 40/180 (22%), Positives = 72/180 (40%), Gaps = 34/180 (18%) Query: 11 QQYECVAEIGEGAYGKVFKARD------------------LKNGGRFVALKRVRV-QTGE 51 ++E IGEG +G V++A D +N + L+ R +T + Sbjct: 21 NEFEIQEAIGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAKRNDDLSIGLRGERFGKTFQ 80 Query: 52 EGMPLSTIREVAVLRHLETFEHP---NVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTY 108 G+ S I+E R L F HP +V+R ++ + + +++ Sbjct: 81 AGLN-SFIQEA---RLLARFSHPGLLHVLRFWEENGTAYMGTQFYSGTTLKNLQAQQPEK 136 Query: 109 LDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLAR 168 +D+ I+ ++ L ++ +H +HRD+ NI + S L DFG AR Sbjct: 137 IDEA--------WIRRLLPPLFSAINTIHQEGYLHRDISLDNIQIQESQLPVLLDFGSAR 188 >6EQI-C nrPDB Length = 433 Score = 33.5 bits (75), Expect = 0.13, Method: Compositional matrix adjust. Identities = 54/192 (28%), Positives = 72/192 (37%), Gaps = 65/192 (33%) Query: 73 HPNVVRLFDVCTVSRTD----------------------RETKLTLVFEHVDQDLTTYL- 109 HPN+VR++ V D R L LV + D L YL Sbjct: 101 HPNIVRMYSVFADRIPDLQCNKQLYPEALPPRINPEGSGRNMSLFLVMKRYDCTLKEYLR 160 Query: 110 DKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVT-SSGQ----IKLADF 164 DK P + ++ QLL + ++ H + HRDLK NILV S G I + DF Sbjct: 161 DKTPN----MRSSILLLSQLLEAVAHMNIHNISHRDLKSDNILVDLSEGDAYPTIVITDF 216 Query: 165 GLARIYSFQMALTSVVVTLWYR-------------APEVLLQSSYATP----------VD 201 G + Q L + YR APE+ + A P D Sbjct: 217 GCC-LCDKQNGL-----VIPYRSEDQDKGGNRALMAPEI----ANAKPGTFSWLNYKKSD 266 Query: 202 LWSVGCIFAEMF 213 LW+VG I E+F Sbjct: 267 LWAVGAIAYEIF 278 >6EWX-A nrPDB Length = 484 Score = 33.5 bits (75), Expect = 0.13, Method: Compositional matrix adjust. Identities = 15/40 (37%), Positives = 24/40 (60%) Query: 114 EPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILV 153 EP V + ++ QL GL+ L H ++HRDL +N+L+ Sbjct: 204 EPEVYERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLL 243 >5VE6-A nrPDB Length = 492 Score = 32.0 bits (71), Expect = 0.33, Method: Compositional matrix adjust. Identities = 12/29 (41%), Positives = 20/29 (68%) Query: 125 MMFQLLRGLDFLHSHRVVHRDLKPQNILV 153 ++ QL GL+ L H ++HRDL +N+L+ Sbjct: 213 LLLQLCNGLEHLKEHGIIHRDLCLENLLL 241 >4L00-A nrPDB Length = 304 Score = 32.0 bits (71), Expect = 0.38, Method: Compositional matrix adjust. Identities = 40/197 (20%), Positives = 74/197 (37%), Gaps = 49/197 (24%) Query: 128 QLLRGLDFLHSHRVVHRDLKPQNILVTSSGQ-------IKLADFGLA-RIYSFQMALTSV 179 QL L +L +VH ++ +N+L+ G IKL+D G+ + S Q + + Sbjct: 141 QLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERI 200 Query: 180 VVTLWYRAPEVLLQS-SYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLP 238 + APE + S + + D WS G E I Sbjct: 201 P----WIAPECVEDSKNLSVAADKWSFGTTLWE-----------------------ICYN 233 Query: 239 GEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHP 298 GE + ++ F+ +P+ ++ DL+ +C+ ++P +R P Sbjct: 234 GEIPLKDKTLIEKERFYESRCRPVTPSCKEL----ADLMTRCMNYDPNQR---------P 280 Query: 299 YFQDLERCKENLDSHLP 315 +F+ + R L+ P Sbjct: 281 FFRAIMRDINKLEEQNP 297 >5TX1-A nrPDB Length = 952 Score = 32.0 bits (71), Expect = 0.39, Method: Compositional matrix adjust. Identities = 19/42 (45%), Positives = 23/42 (54%), Gaps = 4/42 (9%) Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKV 112 F +P V DV T DR +LTL F VD++ TTYL K Sbjct: 45 FRNPTVAPTHDVTT----DRSQRLTLRFVPVDREATTYLYKA 82 >4CI6-B nrPDB Length = 643 Score = 32.0 bits (71), Expect = 0.40, Method: Compositional matrix adjust. Identities = 28/105 (26%), Positives = 49/105 (46%), Gaps = 11/105 (10%) Query: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-----QDLTTYLDKVPEPGVPTE----TI 122 +HPN+ + + V +R L+ + VD L + D + + +E TI Sbjct: 100 KHPNLANVHGMAVVPYGNR-YYYALLMDEVDGWRCSDTLRSLADSWKQGKINSEAYWGTI 158 Query: 123 KDMMFQLLRGLDFLHSHRVVHRDLKPQNILVT-SSGQIKLADFGL 166 K + +LL + L +VH D+KP N++ +SG+ + D GL Sbjct: 159 KFIAHRLLDVTNHLAKAGIVHNDIKPGNVVFDRASGEPVVIDLGL 203 >3REP-A nrPDB Length = 271 Score = 32.0 bits (71), Expect = 0.41, Method: Compositional matrix adjust. Identities = 47/223 (21%), Positives = 87/223 (39%), Gaps = 21/223 (9%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 +Q + ++ E G+++K R G + +K ++V+ E LR Sbjct: 10 KQLNFLTKLNENHSGELWKGR---WQGNDIVVKVLKVRDWSTRKSRDFNEECPRLR---I 63 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130 F HPNV+ + C T +T + L L + V + Sbjct: 64 FSHPNVLPVLGACQSPPAPHPTLITHWMPY--GSLYNVLHEGTNFVVDQSQAVKFALDMA 121 Query: 131 RGLDFLHSHR--VVHRDLKPQNILVTS--SGQIKLADFGLARIYSFQMALTSVVVTLWYR 186 RG+ FLH+ + L +++++ + +I +AD +SFQ + + W Sbjct: 122 RGMAFLHTLEPLIPRHALNSRSVMIDEDMTARISMADVK----FSFQ-SPGRMYAPAWV- 175 Query: 187 APEVLLQSSYAT---PVDLWSVGCIFAEMFRRKPLFRGSSDVD 226 APE L + T D+WS + E+ R+ F S+++ Sbjct: 176 APEALQKKPEDTNRRSADMWSFAVLLWELVTREVPFADLSNME 218 >4AZV-A nrPDB Length = 569 Score = 31.6 bits (70), Expect = 0.55, Method: Compositional matrix adjust. Identities = 14/43 (32%), Positives = 23/43 (53%) Query: 123 KDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFG 165 + ++ LLR L L H D++P N++V + +L DFG Sbjct: 342 EKILGSLLRSLAALEKQGFWHDDVRPWNVMVDARQHARLIDFG 384 >5DMZ-A nrPDB Length = 365 Score = 31.2 bits (69), Expect = 0.60, Method: Compositional matrix adjust. Identities = 42/215 (19%), Positives = 84/215 (39%), Gaps = 27/215 (12%) Query: 19 IGEGAYGKVFKA-----RDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEH 73 +GEGA+ +V++A D KN +FV LK + E + + E F Sbjct: 73 LGEGAFAQVYEATQGDLNDAKNKQKFV-LKVQKPANPWEFYIGTQLMERLKPSMQHMFMK 131 Query: 74 PNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGL 133 LF +V + + TL+ + PE +P + ++L + Sbjct: 132 FYSAHLFQNGSVLVGELYSYGTLL------NAINLYKNTPEKVMPQGLVISFAMRMLYMI 185 Query: 134 DFLHSHRVVHRDLKPQNILVTS-----------SGQIKLADFGLA---RIYSFQMALTSV 179 + +H ++H D+KP N ++ + S + L D G + +++ T+ Sbjct: 186 EQVHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMKLFPKGTIFTAK 245 Query: 180 VVTLWYRAPEVLLQSSYATPVDLWSVGC-IFAEMF 213 T ++ E+L + +D + V ++ +F Sbjct: 246 CETSGFQCVEMLSNKPWNYQIDYFGVAATVYCMLF 280 >4AZW-A nrPDB Length = 471 Score = 30.8 bits (68), Expect = 0.81, Method: Compositional matrix adjust. Identities = 14/43 (32%), Positives = 23/43 (53%) Query: 123 KDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFG 165 + ++ LLR L L H D++P N++V + +L DFG Sbjct: 342 EKILGSLLRSLAALEKKGFWHDDVRPWNVMVDARQHARLIDFG 384 >3NNR-A nrPDB Length = 228 Score = 30.0 bits (66), Expect = 1.2, Method: Compositional matrix adjust. Identities = 20/51 (39%), Positives = 30/51 (58%), Gaps = 3/51 (5%) Query: 97 VFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLK 147 +F+ ++ + YLD +PE P T++DM F L D L S+R HRDL+ Sbjct: 56 IFQEYEKLVDYYLD-IPE-DRPI-TLEDMTFYLESVFDGLWSYRFFHRDLE 103 >3EMC-A nrPDB Length = 331 Score = 29.6 bits (65), Expect = 2.1, Method: Compositional matrix adjust. Identities = 18/89 (20%), Positives = 39/89 (43%) Query: 48 QTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTT 107 + +E + + R + V H + + +F+ + RE L+ + +H+D + Sbjct: 61 EAADEIVDFAVARGIGVRGHTLVWHNQTPAWMFEDASGGTASREMMLSRLKQHIDTVVGR 120 Query: 108 YLDKVPEPGVPTETIKDMMFQLLRGLDFL 136 Y D++ V E I+D ++R +L Sbjct: 121 YKDQIYAWDVVNEAIEDKTDLIMRDTKWL 149 >2WFP-A nrPDB Length = 394 Score = 29.3 bits (64), Expect = 2.2, Method: Compositional matrix adjust. Identities = 19/77 (24%), Positives = 36/77 (46%), Gaps = 7/77 (9%) Query: 233 DVIGLPGEEDWPRDVALPRQAFHSKSAQP------IEKFVTDIDELGKDLLLKCLTFNPA 286 ++ + GEE R +A+ + A +S+ +P I ++ D L LLL + NP Sbjct: 189 SLLNMQGEEK-SRALAVLKAALNSQQGEPWQTIRVISEYYPDDSGLFSPLLLNVVKLNPG 247 Query: 287 KRISAYSALSHPYFQDL 303 + + ++ H Y Q + Sbjct: 248 EAMFLFAETPHAYLQGV 264 >5C01-A nrPDB Length = 342 Score = 29.3 bits (64), Expect = 2.4, Method: Compositional matrix adjust. Identities = 26/94 (27%), Positives = 43/94 (45%), Gaps = 12/94 (12%) Query: 128 QLLRGLDFLHSHRVVHRDLKPQNILVTSSGQ-------IKLADFGLARIYSFQMALTSVV 180 QL L +L + +VH ++ +NIL+ G IKL+D G+ ++ V Sbjct: 188 QLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGL---GALSREERV 244 Query: 181 VTLWYRAPEVLL--QSSYATPVDLWSVGCIFAEM 212 + + APE L +S +T +D W G E+ Sbjct: 245 ERIPWLAPECLPGGANSLSTAMDKWGFGATLLEI 278 >4WOV-A nrPDB Length = 317 Score = 29.3 bits (64), Expect = 2.6, Method: Compositional matrix adjust. Identities = 26/94 (27%), Positives = 43/94 (45%), Gaps = 12/94 (12%) Query: 128 QLLRGLDFLHSHRVVHRDLKPQNILVTSSGQ-------IKLADFGLARIYSFQMALTSVV 180 QL L +L + +VH ++ +NIL+ G IKL+D G+ ++ V Sbjct: 165 QLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGL---GALSREERV 221 Query: 181 VTLWYRAPEVLL--QSSYATPVDLWSVGCIFAEM 212 + + APE L +S +T +D W G E+ Sbjct: 222 ERIPWLAPECLPGGANSLSTAMDKWGFGATLLEI 255 >4L68-A nrPDB Length = 340 Score = 28.9 bits (63), Expect = 3.0, Method: Compositional matrix adjust. Identities = 52/253 (20%), Positives = 89/253 (35%), Gaps = 55/253 (21%) Query: 65 LRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKD 124 + L H N+ L C V E + LV++++ L + T Sbjct: 86 MNQLWELRHSNLAPLLGFCVV-----EEEKFLVYKYMSNGTLHSLLDSNRGELDWSTRFR 140 Query: 125 MMFQLLRGLDFLHSH---RVVHRDLKPQNILVTSSGQIKLADFGLARIY--------SFQ 173 + RGL +LH ++H+++ IL+ ++ D GLAR+ SF Sbjct: 141 IGLGAARGLAWLHHGCRPPILHQNICSSVILIDEDFDARIIDSGLARLMVPSDNNESSF- 199 Query: 174 MALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILD 233 +T + Y APE + D++ +G + E L L Sbjct: 200 --MTGDLGEFGYVAPEYSTTMLASLKGDVYGLGVVLLE----------------LATGLK 241 Query: 234 VIGLPGEE----DWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKD--------LLLKCL 281 +G G + DW + + S + E F +I G D + L C+ Sbjct: 242 AVGGEGFKGSLVDWVKQL--------ESSGRIAETFDENIRGKGHDEEISKFVEIALNCV 293 Query: 282 TFNPAKRISAYSA 294 + P +R S + A Sbjct: 294 SSRPKERWSMFQA 306 >2V8D-A nrPDB Length = 474 Score = 28.9 bits (63), Expect = 3.1, Method: Compositional matrix adjust. Identities = 20/61 (32%), Positives = 26/61 (42%) Query: 25 GKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCT 84 G +F KNGG+ A E G + +A L L TF+ N V +DVC Sbjct: 93 GNMFAVYPGKNGGKPTATGSHLDTQPEAGKYDGILGVLAGLEVLRTFKDNNYVPNYDVCV 152 Query: 85 V 85 V Sbjct: 153 V 153 >5YPX-A nrPDB Length = 223 Score = 28.1 bits (61), Expect = 4.9, Method: Compositional matrix adjust. Identities = 18/49 (36%), Positives = 25/49 (51%) Query: 99 EHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLK 147 E + Q L T L K P P E IKD++ L+ +D H R+ +D K Sbjct: 137 EEMFQMLKTCLVKQPTEEDPDEGIKDLVEIALKKMDHDHDSRLSKKDFK 185 >6J6I-B nrPDB Length = 351 Score = 28.1 bits (61), Expect = 5.0, Method: Compositional matrix adjust. Identities = 27/115 (23%), Positives = 50/115 (43%), Gaps = 20/115 (17%) Query: 128 QLLRGLDFLHS---HRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTS------ 178 ++ + +LH+ ++HRD+KP ++ + + KL+D SF ++L Sbjct: 171 EIANAVTYLHTAFPKIIIHRDVKPMHVFLDKNWTAKLSDL------SFSISLPEGKSRIE 224 Query: 179 ---VVVTLWYRAPEVLLQSSYATP-VDLWSVGCIFAEMFRRKPLFRGSSDVDQLG 229 V+ T Y P + ++ + T D++S G + KP SD D G Sbjct: 225 AEWVLGTFGYIDP-LYHKTCFVTEYTDVYSFGICLLVIITGKPAIMTISDGDLQG 278 >2OBE-A nrPDB Length = 932 Score = 28.1 bits (61), Expect = 5.5, Method: Compositional matrix adjust. Identities = 18/42 (42%), Positives = 22/42 (52%), Gaps = 4/42 (9%) Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKV 112 F +P V DV T DR +LTL F VD++ TY KV Sbjct: 44 FRNPTVAPTHDVTT----DRSQRLTLRFVPVDREDNTYSYKV 81 >3DZO-A nrPDB Length = 413 Score = 28.1 bits (61), Expect = 6.0, Method: Compositional matrix adjust. Identities = 13/40 (32%), Positives = 23/40 (57%) Query: 125 MMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADF 164 + Q++R L LH + +VH L+P +I++ G + L F Sbjct: 216 LTLQVIRLLASLHHYGLVHTYLRPVDIVLDQRGGVFLTGF 255 >3A9Z-A nrPDB Length = 432 Score = 28.1 bits (61), Expect = 6.0, Method: Compositional matrix adjust. Identities = 12/30 (40%), Positives = 18/30 (60%) Query: 248 ALPRQAFHSKSAQPIEKFVTDIDELGKDLL 277 LPR H+ +AQ + K D+++LG D L Sbjct: 212 GLPRVLVHTDAAQALGKRRVDVEDLGVDFL 241 >3BYV-A nrPDB Length = 377 Score = 27.7 bits (60), Expect = 7.6, Method: Compositional matrix adjust. Identities = 13/40 (32%), Positives = 23/40 (57%) Query: 125 MMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADF 164 + Q++R L LH + +VH L+P +I++ G + L F Sbjct: 211 LTLQVIRLLASLHHYGLVHTYLRPVDIVLDQRGGVFLTGF 250 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 1G3N-A nrPDB 475 e-135 2W96-B nrPDB 370 e-103 2BPM-A nrPDB 333 5e-92 3NIZ-A nrPDB 324 4e-89 6GU6-A nrPDB 320 6e-88 1V0B-A nrPDB 313 7e-86 4NST-A nrPDB 308 3e-84 5EFQ-A nrPDB 306 6e-84 4AU8-A nrPDB 306 1e-83 2F9G-A nrPDB 303 6e-83 4KRC-A nrPDB 301 4e-82 6DTL-A nrPDB 297 5e-81 1CM8-A nrPDB 295 2e-80 5Z33-A nrPDB 295 2e-80 4MYG-A nrPDB 294 3e-80 4QNY-A nrPDB 293 6e-80 4EWQ-A nrPDB 290 5e-79 4QTB-A nrPDB 289 1e-78 4AGU-A nrPDB 289 1e-78 5NGU-A nrPDB 288 2e-78 3OHT-A nrPDB 288 2e-78 1UA2-A nrPDB 287 3e-78 1JNK-A nrPDB 286 7e-78 3FI2-A nrPDB 283 6e-77 5AWM-A nrPDB 283 8e-77 2XS0-A nrPDB 282 1e-76 3GC9-A nrPDB 282 1e-76 3LIJ-A nrPDB 282 2e-76 3E7O-A nrPDB 282 2e-76 4IC8-A nrPDB 281 2e-76 4BBM-A nrPDB 281 4e-76 5JN2-A nrPDB 279 9e-76 3MIA-A nrPDB 279 1e-75 4ZSG-A nrPDB 278 3e-75 3NCG-A nrPDB 278 3e-75 3OZ6-A nrPDB 277 4e-75 4MVF-A nrPDB 276 7e-75 3DFA-A nrPDB 273 7e-74 3HZT-A nrPDB 273 7e-74 3GC0-A nrPDB 272 2e-73 4BGQ-A nrPDB 271 3e-73 3DXN-A nrPDB 271 3e-73 5G6V-A nrPDB 270 7e-73 3MA6-A nrPDB 269 1e-72 4E7W-A nrPDB 269 1e-72 4YZB-A nrPDB 267 3e-72 3PG1-A nrPDB 267 6e-72 2BDW-A nrPDB 265 2e-71 2V7O-A nrPDB 265 2e-71 5FG8-A nrPDB 264 4e-71 2VN9-A nrPDB 264 4e-71 5AIR-A nrPDB 264 5e-71 3RP9-A nrPDB 263 9e-71 3KK8-A nrPDB 262 2e-70 3SOA-A nrPDB 261 4e-70 3COM-A nrPDB 261 4e-70 5U6Y-A nrPDB 261 4e-70 4O2Z-A nrPDB 260 6e-70 3N9X-A nrPDB 260 8e-70 4FG9-A nrPDB 259 1e-69 2VZ6-A nrPDB 259 1e-69 5Y86-A nrPDB 258 2e-69 4RGJ-A nrPDB 258 3e-69 3NIE-A nrPDB 257 4e-69 5IG1-A nrPDB 257 5e-69 3Q5I-A nrPDB 257 5e-69 2JC6-A nrPDB 257 5e-69 3BHH-A nrPDB 255 1e-68 4LG4-A nrPDB 255 2e-68 5YKS-A nrPDB 255 3e-68 3ZDU-A nrPDB 254 3e-68 3E3P-A nrPDB 253 6e-68 6AO5-A nrPDB 253 7e-68 3MN3-A nrPDB 253 8e-68 5D9K-A nrPDB 253 9e-68 2J90-A nrPDB 252 1e-67 3EB0-A nrPDB 252 1e-67 4UZD-A nrPDB 250 4e-67 6FD3-A nrPDB 250 5e-67 5ZTN-A nrPDB 250 6e-67 3D2K-A nrPDB 249 9e-67 5ES1-A nrPDB 247 5e-66 3GUB-A nrPDB 247 6e-66 4L42-A nrPDB 246 1e-65 3H4J-B nrPDB 246 1e-65 3TAC-A nrPDB 245 1e-65 2YAB-A nrPDB 245 1e-65 2W4O-A nrPDB 245 1e-65 2JAM-A nrPDB 245 2e-65 4RLP-A nrPDB 244 4e-65 2QNJ-A nrPDB 244 4e-65 2Z7Q-A nrPDB 244 5e-65 5KZ7-A nrPDB 244 5e-65 2I6L-A nrPDB 244 5e-65 2Y7J-A nrPDB 243 6e-65 1FOT-A nrPDB 243 8e-65 3Q53-A nrPDB 242 1e-64 2F57-A nrPDB 242 1e-64 4FIE-A nrPDB 242 1e-64 4NIF-A nrPDB 242 2e-64 4CSV-A nrPDB 241 3e-64 4JDH-A nrPDB 241 4e-64 5XZW-A nrPDB 241 4e-64 5JZN-A nrPDB 240 4e-64 4REW-A nrPDB 240 5e-64 5D7A-A nrPDB 240 5e-64 2Q0N-A nrPDB 240 5e-64 2A27-A nrPDB 240 5e-64 4XBR-A nrPDB 240 6e-64 4CZT-A nrPDB 240 7e-64 2UV2-A nrPDB 240 7e-64 6FDY-U nrPDB 240 8e-64 6HXF-B nrPDB 240 9e-64 1PHK-A nrPDB 240 9e-64 2YCR-A nrPDB 239 9e-64 1ZWS-A nrPDB 239 2e-63 4KS7-A nrPDB 239 2e-63 3F3Z-A nrPDB 237 4e-63 3I6U-A nrPDB 237 5e-63 3TXO-A nrPDB 237 5e-63 4JG6-A nrPDB 237 6e-63 5X8I-B nrPDB 236 8e-63 2JDO-A nrPDB 236 1e-62 4QMW-A nrPDB 236 1e-62 2XIK-A nrPDB 236 1e-62 4RED-A nrPDB 235 1e-62 4CFH-A nrPDB 235 1e-62 5WAX-A nrPDB 235 1e-62 4PDS-A nrPDB 235 3e-62 3HDN-A nrPDB 234 3e-62 2X4F-A nrPDB 234 3e-62 4CFF-A nrPDB 234 4e-62 3UTO-A nrPDB 234 5e-62 4FZF-B nrPDB 234 5e-62 5EZV-A nrPDB 233 7e-62 3IS5-A nrPDB 232 1e-61 5KCV-A nrPDB 232 1e-61 5LOH-A nrPDB 232 1e-61 1KOA-A nrPDB 232 2e-61 5J5T-A nrPDB 232 2e-61 4D28-A nrPDB 231 3e-61 3MV5-A nrPDB 231 3e-61 1KOB-A nrPDB 231 4e-61 5F9E-A nrPDB 230 4e-61 4JXF-A nrPDB 230 5e-61 6O6Q-A nrPDB 230 6e-61 3RAW-A nrPDB 230 6e-61 2HW6-A nrPDB 230 7e-61 6FYV-A nrPDB 229 9e-61 4RA4-A nrPDB 229 9e-61 5UNP-A nrPDB 229 9e-61 3LM0-A nrPDB 229 1e-60 2YZA-A nrPDB 228 2e-60 2HAK-A nrPDB 228 3e-60 3DAK-A nrPDB 228 3e-60 6CKI-A nrPDB 228 3e-60 2WO6-A nrPDB 228 3e-60 4WNO-A nrPDB 228 3e-60 6C9D-A nrPDB 228 3e-60 3ORZ-A nrPDB 227 4e-60 4CQG-A nrPDB 227 4e-60 3ZUT-A nrPDB 227 5e-60 4AF3-A nrPDB 227 6e-60 3UC3-A nrPDB 227 7e-60 5DBX-A nrPDB 226 9e-60 4MD7-E nrPDB 226 1e-59 6QAU-A nrPDB 226 1e-59 4D2V-A nrPDB 226 1e-59 4B8L-A nrPDB 226 1e-59 4I6B-A nrPDB 225 1e-59 3UDB-A nrPDB 225 2e-59 2PVN-A nrPDB 225 2e-59 3FXW-A nrPDB 224 3e-59 2H8H-A nrPDB 224 3e-59 4U41-A nrPDB 224 4e-59 6F3F-A nrPDB 224 4e-59 3A8W-A nrPDB 224 5e-59 1VZO-A nrPDB 224 5e-59 6ED6-A nrPDB 223 8e-59 3NYO-A nrPDB 223 9e-59 2DQ7-X nrPDB 223 1e-58 5N23-A nrPDB 222 1e-58 5X3F-B nrPDB 222 1e-58 1U5R-A nrPDB 222 2e-58 4B6L-A nrPDB 222 2e-58 4EBW-A nrPDB 222 2e-58 4APC-A nrPDB 221 3e-58 6E9W-A nrPDB 221 3e-58 1NY3-A nrPDB 221 4e-58 2GCD-A nrPDB 221 4e-58 2WTK-C nrPDB 220 5e-58 4WB7-A nrPDB 220 6e-58 3KA0-A nrPDB 220 6e-58 2OZA-A nrPDB 220 7e-58 5MJB-A nrPDB 220 8e-58 5SYS-A nrPDB 220 9e-58 6HMD-A nrPDB 219 1e-57 4XEY-B nrPDB 219 1e-57 6BDL-A nrPDB 219 1e-57 3KN6-A nrPDB 219 1e-57 3DB8-A nrPDB 219 1e-57 2FO0-A nrPDB 219 1e-57 3HKO-A nrPDB 219 1e-57 4CRL-A nrPDB 219 1e-57 2J0K-A nrPDB 219 2e-57 3TKU-A nrPDB 219 2e-57 6EII-A nrPDB 219 2e-57 4C0T-A nrPDB 218 2e-57 4YNZ-A nrPDB 218 2e-57 4AW2-A nrPDB 218 3e-57 6CMJ-A nrPDB 218 3e-57 3PFQ-A nrPDB 217 4e-57 5L6P-A nrPDB 217 5e-57 6NPU-A nrPDB 217 6e-57 3DKO-A nrPDB 217 7e-57 4TNB-A nrPDB 217 8e-57 4P5Q-A nrPDB 216 1e-56 2I0E-A nrPDB 215 2e-56 2WQN-A nrPDB 215 2e-56 2XYN-A nrPDB 215 2e-56 1JPA-A nrPDB 215 2e-56 4GS6-A nrPDB 215 3e-56 5XVU-A nrPDB 215 3e-56 3A4O-X nrPDB 214 4e-56 2R2P-A nrPDB 214 4e-56 4FR4-A nrPDB 214 5e-56 5YV8-A nrPDB 214 5e-56 4E93-A nrPDB 214 6e-56 2Y6O-A nrPDB 213 7e-56 2OU7-A nrPDB 213 8e-56 6CQF-A nrPDB 213 9e-56 2VWV-A nrPDB 213 1e-55 5DYK-A nrPDB 212 2e-55 4J52-A nrPDB 212 2e-55 2XNP-A nrPDB 212 2e-55 3ALO-A nrPDB 211 3e-55 3PPZ-A nrPDB 211 3e-55 5H2U-A nrPDB 211 4e-55 5U6B-A nrPDB 210 5e-55 6GQK-A nrPDB 210 7e-55 5VO2-A nrPDB 210 7e-55 3TT0-A nrPDB 210 8e-55 5KKR-C nrPDB 209 1e-54 2HK5-A nrPDB 209 1e-54 3VN9-A nrPDB 209 1e-54 4IAN-A nrPDB 209 1e-54 6GVJ-A nrPDB 209 2e-54 5A46-A nrPDB 209 2e-54 4PDO-A nrPDB 209 2e-54 5FET-A nrPDB 208 3e-54 3GQL-A nrPDB 207 4e-54 2VD5-A nrPDB 207 4e-54 1TKI-A nrPDB 207 4e-54 4XLV-A nrPDB 207 6e-54 1AD5-A nrPDB 207 6e-54 4AN9-A nrPDB 207 7e-54 4LFI-A nrPDB 206 8e-54 4XCU-A nrPDB 206 9e-54 3EQC-A nrPDB 206 9e-54 6E2O-A nrPDB 206 1e-53 3V5Q-A nrPDB 206 1e-53 3FME-A nrPDB 206 1e-53 1FVR-A nrPDB 206 1e-53 6BXI-A nrPDB 205 2e-53 2PL0-A nrPDB 205 2e-53 4OTD-A nrPDB 205 2e-53 4CRS-A nrPDB 205 2e-53 2PSQ-A nrPDB 205 2e-53 4YHJ-A nrPDB 205 2e-53 1S9I-A nrPDB 204 3e-53 3KUL-B nrPDB 204 4e-53 3HMP-A nrPDB 204 4e-53 2OGV-A nrPDB 204 4e-53 4K33-A nrPDB 204 5e-53 5UUU-A nrPDB 203 5e-53 2BRG-A nrPDB 203 6e-53 3BEA-A nrPDB 203 6e-53 3C51-A nrPDB 203 7e-53 3KRL-A nrPDB 203 8e-53 3PVW-A nrPDB 203 1e-52 2X7G-A nrPDB 202 1e-52 2JD5-A nrPDB 202 2e-52 5HI2-A nrPDB 202 2e-52 4PWN-A nrPDB 202 2e-52 5AP3-A nrPDB 202 2e-52 2ZMD-A nrPDB 201 3e-52 4LQP-A nrPDB 201 3e-52 3CJF-A nrPDB 201 4e-52 5O2B-A nrPDB 200 6e-52 4WUA-A nrPDB 200 7e-52 4AT3-A nrPDB 200 7e-52 5EG3-A nrPDB 200 7e-52 4UYA-A nrPDB 200 1e-51 5O2C-A nrPDB 199 1e-51 4KIK-B nrPDB 199 1e-51 4R7H-A nrPDB 199 2e-51 6FEX-A nrPDB 198 2e-51 3QUP-A nrPDB 198 2e-51 6DBN-A nrPDB 198 2e-51 1K9A-A nrPDB 198 2e-51 5HIE-A nrPDB 198 2e-51 6CCF-A nrPDB 198 2e-51 4OLI-A nrPDB 198 3e-51 4H1J-A nrPDB 198 3e-51 1LUF-A nrPDB 198 4e-51 4XUF-A nrPDB 197 4e-51 6BSD-A nrPDB 197 5e-51 5X02-A nrPDB 197 6e-51 4UY9-A nrPDB 197 7e-51 5B2L-A nrPDB 197 7e-51 3G0E-A nrPDB 197 8e-51 3QGY-A nrPDB 197 8e-51 6DBM-A nrPDB 196 1e-50 1BYG-A nrPDB 196 1e-50 5KMM-A nrPDB 196 1e-50 5TUR-A nrPDB 196 1e-50 3ORP-A nrPDB 195 2e-50 3BGP-A nrPDB 195 2e-50 3DTC-A nrPDB 195 3e-50 5X5O-A nrPDB 195 3e-50 4EQM-A nrPDB 195 3e-50 3ZBF-A nrPDB 195 3e-50 4E20-A nrPDB 194 5e-50 4RC3-A nrPDB 194 5e-50 3LLT-A nrPDB 193 7e-50 2W1I-A nrPDB 193 8e-50 3OMV-A nrPDB 193 9e-50 1ZXE-A nrPDB 193 1e-49 3IO7-A nrPDB 192 2e-49 5AMN-A nrPDB 192 2e-49 5GRN-A nrPDB 192 2e-49 3QA8-A nrPDB 192 3e-49 4HZS-A nrPDB 191 3e-49 5TQX-A nrPDB 191 3e-49 4Y93-A nrPDB 190 5e-49 3BBT-B nrPDB 190 6e-49 5U6C-A nrPDB 190 6e-49 4HVI-A nrPDB 190 7e-49 4XI2-A nrPDB 190 9e-49 1U54-B nrPDB 190 1e-48 3I81-A nrPDB 189 1e-48 6E4F-A nrPDB 189 1e-48 5HLW-A nrPDB 189 1e-48 6FER-A nrPDB 189 2e-48 1U59-A nrPDB 188 2e-48 2A1A-B nrPDB 188 2e-48 3C1X-A nrPDB 188 3e-48 3SXS-A nrPDB 188 3e-48 2OZO-A nrPDB 187 5e-48 5FM2-A nrPDB 187 7e-48 3PP0-A nrPDB 187 8e-48 5HVK-A nrPDB 186 9e-48 3M42-A nrPDB 186 1e-47 2WTK-B nrPDB 186 1e-47 4LRM-A nrPDB 185 2e-47 3UIU-A nrPDB 184 3e-47 6CTH-A nrPDB 184 4e-47 5GNK-A nrPDB 183 9e-47 3DLS-A nrPDB 182 1e-46 3LZB-A nrPDB 182 2e-46 3ZZW-A nrPDB 182 2e-46 4M7I-A nrPDB 182 3e-46 5VD3-A nrPDB 182 3e-46 4FL3-A nrPDB 181 3e-46 5TOS-A nrPDB 181 3e-46 4C59-A nrPDB 180 9e-46 3PLS-A nrPDB 180 1e-45 3Q4U-A nrPDB 180 1e-45 4PL5-B nrPDB 179 1e-45 4OW8-A nrPDB 178 2e-45 4X3F-A nrPDB 178 2e-45 6B2Q-A nrPDB 178 2e-45 5O0Y-A nrPDB 178 2e-45 4X7Q-B nrPDB 178 3e-45 4Y83-A nrPDB 178 3e-45 5C26-A nrPDB 177 4e-45 2PMN-X nrPDB 177 9e-45 6HV0-A nrPDB 176 1e-44 6J5U-C nrPDB 176 1e-44 5UIU-A nrPDB 176 1e-44 2RIO-A nrPDB 174 4e-44 4YFF-A nrPDB 174 5e-44 4TPT-A nrPDB 172 2e-43 3AOX-A nrPDB 172 2e-43 3MY0-A nrPDB 171 5e-43 3MDY-A nrPDB 170 7e-43 5WNL-A nrPDB 170 8e-43 5LPZ-A nrPDB 170 1e-42 5LPV-A nrPDB 169 2e-42 5IKW-A nrPDB 169 2e-42 4NEU-A nrPDB 168 4e-42 2QKW-B nrPDB 167 6e-42 4IDT-A nrPDB 167 7e-42 5TE0-A nrPDB 166 1e-41 2BUJ-A nrPDB 165 2e-41 5WNO-A nrPDB 165 2e-41 3UIM-A nrPDB 165 3e-41 3G2F-A nrPDB 164 4e-41 3LMG-A nrPDB 163 1e-40 3SOC-A nrPDB 162 3e-40 4F0G-A nrPDB 160 5e-40 3QD2-B nrPDB 160 9e-40 5XD6-A nrPDB 159 2e-39 4JLC-A nrPDB 158 2e-39 1PY5-A nrPDB 158 3e-39 6O8B-A nrPDB 157 5e-39 4EUU-A nrPDB 157 5e-39 4EUT-A nrPDB 156 1e-38 4G3E-A nrPDB 155 2e-38 4F9B-A nrPDB 155 2e-38 5AR8-A nrPDB 153 8e-38 2H34-A nrPDB 153 1e-37 6NT9-A nrPDB 153 1e-37 5E8V-A nrPDB 153 1e-37 4BTK-A nrPDB 150 1e-36 2Y4I-B nrPDB 150 1e-36 4NFN-A nrPDB 149 2e-36 4M66-A nrPDB 148 2e-36 2QLU-A nrPDB 148 2e-36 4M69-B nrPDB 148 3e-36 4BTF-A nrPDB 148 4e-36 4MWI-A nrPDB 147 6e-36 6BFN-A nrPDB 146 1e-35 3HNG-A nrPDB 141 3e-34 3VHK-A nrPDB 140 7e-34 2PZI-A nrPDB 138 3e-33 4Y12-A nrPDB 138 3e-33 3SV0-A nrPDB 136 1e-32 5VC6-A nrPDB 133 8e-32 5L2Q-C nrPDB 130 9e-31 4JRN-A nrPDB 129 1e-30 4RT7-A nrPDB 128 4e-30 4TN6-A nrPDB 127 5e-30 5VDK-A nrPDB 126 2e-29 5X18-A nrPDB 121 4e-28 5M07-A nrPDB 121 5e-28 2CHL-A nrPDB 120 9e-28 5OAT-A nrPDB 117 6e-27 2C47-A nrPDB 116 2e-26 4NT4-A nrPDB 115 4e-26 2CMW-A nrPDB 112 2e-25 5UV4-A nrPDB 107 6e-24 4CYJ-A nrPDB 92 3e-19 4O1O-A nrPDB 71 8e-13 Sequences not found previously or not previously below threshold: 5J0A-A nrPDB 128 4e-30 5CEK-A nrPDB 127 7e-30 6DC0-A nrPDB 126 9e-30 5FQD-C nrPDB 125 4e-29 5X1R-A nrPDB 110 6e-25 4XHH-A nrPDB 110 7e-25 4L00-A nrPDB 110 8e-25 3REP-A nrPDB 110 1e-24 4XHL-A nrPDB 109 1e-24 1CSN-A nrPDB 106 1e-23 4L68-A nrPDB 103 8e-23 6J6I-B nrPDB 103 1e-22 6EQI-C nrPDB 101 5e-22 5USZ-A nrPDB 96 2e-20 4I94-A nrPDB 94 7e-20 5C01-A nrPDB 92 5e-19 4WOV-A nrPDB 91 7e-19 5UU1-A nrPDB 85 4e-17 2RSV-A nrPDB 80 1e-15 2LAV-A nrPDB 79 2e-15 4IX6-A nrPDB 78 4e-15 5CLR-A nrPDB 78 5e-15 6EAS-A nrPDB 76 2e-14 4CI6-B nrPDB 75 4e-14 2JII-A nrPDB 74 9e-14 5DMZ-A nrPDB 73 1e-13 6G4J-A nrPDB 68 5e-12 6EWX-A nrPDB 66 1e-11 4OAU-C nrPDB 66 2e-11 4CZY-B nrPDB 62 4e-10 6BHC-A nrPDB 60 1e-09 6M7Z-A nrPDB 57 1e-08 6G38-A nrPDB 55 5e-08 5GZ9-A nrPDB 53 1e-07 4AZV-A nrPDB 53 2e-07 4AZW-A nrPDB 52 3e-07 3Q60-A nrPDB 51 6e-07 5GZA-A nrPDB 50 1e-06 5VE6-A nrPDB 50 2e-06 3BYV-A nrPDB 48 4e-06 4BWP-A nrPDB 48 6e-06 3ENH-A nrPDB 48 7e-06 3DZO-A nrPDB 43 1e-04 2W1Z-A nrPDB 43 2e-04 6G18-v nrPDB 41 5e-04 6FDN-A nrPDB 40 0.001 4WWA-A nrPDB 38 0.004 6DFL-A nrPDB 36 0.033 1TQM-A nrPDB 35 0.038 5YK0-A nrPDB 33 0.13 5JY7-I nrPDB 33 0.24 4BVU-A nrPDB 31 0.49 1VHE-A nrPDB 31 0.70 6EN4-C nrPDB 31 0.73 6FAI-l nrPDB 30 1.3 6EF6-A nrPDB 30 1.5 >1G3N-A nrPDB Length = 326 Score = 475 bits (1224), Expect = e-135, Method: Composition-based stats. Identities = 326/326 (100%), Positives = 326/326 (100%) Query: 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR 60 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR Sbjct: 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR 60 Query: 61 EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTE 120 EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTE Sbjct: 61 EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTE 120 Query: 121 TIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVV 180 TIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVV Sbjct: 121 TIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVV 180 Query: 181 VTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGE 240 VTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGE Sbjct: 181 VTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGE 240 Query: 241 EDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 EDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF Sbjct: 241 EDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 Query: 301 QDLERCKENLDSHLPPSQNTSELNTA 326 QDLERCKENLDSHLPPSQNTSELNTA Sbjct: 301 QDLERCKENLDSHLPPSQNTSELNTA 326 >2W96-B nrPDB Length = 306 Score = 370 bits (949), Expect = e-103, Method: Composition-based stats. Identities = 212/301 (70%), Positives = 244/301 (81%), Gaps = 1/301 (0%) Query: 8 RADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRH 67 A +YE VAEIG GAYG V+KARD + G FVALK VRV GEEG+P+ST+REVA+LR Sbjct: 1 MATSRYEPVAEIGVGAYGTVYKARD-PHSGHFVALKSVRVPNGEEGLPISTVREVALLRR 59 Query: 68 LETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMF 127 LE FEHPNVVRL DVC SRTDRE K+TLVFEHVDQDL TYLDK P PG+P ETIKD+M Sbjct: 60 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMR 119 Query: 128 QLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRA 187 Q LRGLDFLH++ +VHRDLKP+NILVTS G +KLADFGLARIYS+QMAL VVVTLWYRA Sbjct: 120 QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALDPVVVTLWYRA 179 Query: 188 PEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDV 247 PEVLLQS+YATPVD+WSVGCIFAEMFRRKPLF G+S+ DQLGKI D+IGLP E+DWPRDV Sbjct: 180 PEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDV 239 Query: 248 ALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCK 307 +LPR AF + +P++ V +++E G LLL+ LTFNP KRISA+ AL H Y E Sbjct: 240 SLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNP 299 Query: 308 E 308 E Sbjct: 300 E 300 >2BPM-A nrPDB Length = 309 Score = 333 bits (855), Expect = 5e-92, Method: Composition-based stats. Identities = 147/310 (47%), Positives = 200/310 (64%), Gaps = 13/310 (4%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 + ++ V +IGEG YG V+KAR+ K G VALK++R+ T EG+P + IRE+++L+ L Sbjct: 7 ENFQKVEKIGEGTYGVVYKARN-KLTGEVVALKKIRLDTETEGVPSTAIREISLLKEL-- 63 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130 HPN+V+L DV E KL LVFE + QDL ++D G+P IK +FQLL Sbjct: 64 -NHPNIVKLLDVIHT-----ENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLL 117 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMA-LTSVVVTLWYRAPE 189 +GL F HSHRV+HRDLKPQN+L+ + G IKLADFGLAR + + T VVTLWYRAPE Sbjct: 118 QGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPE 177 Query: 190 VLLQSS-YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA 248 +LL Y+T VD+WS+GCIFAEM R+ LF G S++DQL +I +G P E WP + Sbjct: 178 ILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS 237 Query: 249 LPRQ--AFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERC 306 +P +F + Q K V +DE G+ LL + L ++P KRISA +AL+HP+FQD+ + Sbjct: 238 MPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP 297 Query: 307 KENLDSHLPP 316 +L P Sbjct: 298 VPHLRLERPH 307 >3NIZ-A nrPDB Length = 311 Score = 324 bits (830), Expect = 4e-89, Method: Composition-based stats. Identities = 138/299 (46%), Positives = 193/299 (64%), Gaps = 16/299 (5%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 ++Y+ + ++GEG YG V+KA+D + GR VALKR+R+ +EG+P + IRE+++L+ L Sbjct: 21 EKYQKLEKVGEGTYGVVYKAKD--SQGRIVALKRIRLDAEDEGIPSTAIREISLLKEL-- 76 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130 HPN+V L DV R LTLVFE +++DL LD+ + G+ IK ++QLL Sbjct: 77 -HHPNIVSLIDVIHSERC-----LTLVFEFMEKDLKKVLDE-NKTGLQDSQIKIYLYQLL 129 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMA-LTSVVVTLWYRAPE 189 RG+ H HR++HRDLKPQN+L+ S G +KLADFGLAR + + T VVTLWYRAP+ Sbjct: 130 RGVAHCHQHRILHRDLKPQNLLINSDGALKLADFGLARAFGIPVRSYTHEVVTLWYRAPD 189 Query: 190 VLLQ-SSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA 248 VL+ Y+T VD+WS+GCIFAEM KPLF G +D DQL KI ++G P +WP+ Sbjct: 190 VLMGSKKYSTSVDIWSIGCIFAEMITGKPLFPGVTDDDQLPKIFSILGTPNPREWPQVQE 249 Query: 249 LP---RQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLE 304 LP ++ F +P + + G DLL L F+P KRISA A++HPYF+DL+ Sbjct: 250 LPLWKQRTFQVFEKKPWSSIIPGFCQEGIDLLSNMLCFDPNKRISARDAMNHPYFKDLD 308 >6GU6-A nrPDB Length = 302 Score = 320 bits (820), Expect = 6e-88, Method: Composition-based stats. Identities = 137/299 (45%), Positives = 193/299 (64%), Gaps = 14/299 (4%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 + Y + +IGEG YG V+K R K G+ VA+K++R+++ EEG+P + IRE+++L+ L Sbjct: 7 EDYTKIEKIGEGTYGVVYKGRH-KTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELR- 64 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPE-PGVPTETIKDMMFQL 129 HPN+V L DV ++++L L+FE + DL YLD +P + + +K ++Q+ Sbjct: 65 --HPNIVSLQDVLM-----QDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQI 117 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMA-LTSVVVTLWYRAP 188 L+G+ F HS RV+HRDLKPQN+L+ G IKLADFGLAR + + T VVTLWYR+P Sbjct: 118 LQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSP 177 Query: 189 EVLLQS-SYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDV 247 EVLL S Y+TPVD+WS+G IFAE+ +KPLF G S++DQL +I +G P E WP Sbjct: 178 EVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVE 237 Query: 248 ALPRQA--FHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLE 304 +L F + V ++DE G DLL K L ++PAKRIS AL+HPYF DL+ Sbjct: 238 SLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLD 296 >1V0B-A nrPDB Length = 288 Score = 313 bits (802), Expect = 7e-86, Method: Composition-based stats. Identities = 134/296 (45%), Positives = 191/296 (64%), Gaps = 15/296 (5%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 ++Y + +IGEG YG V+KA++ N G ALK++R++ +EG+P +TIRE+++L+ L+ Sbjct: 2 EKYHGLEKIGEGTYGVVYKAQN--NYGETFALKKIRLEKEDEGIPSTTIREISILKELK- 58 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130 H N+V+L+DV + +L LVFEH+DQDL LD V E G+ + T K + QLL Sbjct: 59 --HSNIVKLYDVIHT-----KKRLVLVFEHLDQDLKKLLD-VCEGGLESVTAKSFLLQLL 110 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQM-ALTSVVVTLWYRAPE 189 G+ + H RV+HRDLKPQN+L+ G++K+ADFGLAR + + T VVTLWYRAP+ Sbjct: 111 NGIAYCHDRRVLHRDLKPQNLLINREGELKIADFGLARAFGIPVRKYTHEVVTLWYRAPD 170 Query: 190 VLLQ-SSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA 248 VL+ Y+T +D+WSVGCIFAEM PLF G S+ DQL +I ++G P ++WP Sbjct: 171 VLMGSKKYSTTIDIWSVGCIFAEMVNGAPLFPGVSEADQLMRIFRILGTPNSKNWPNVTE 230 Query: 249 LPRQ--AFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQD 302 LP+ F P E F+ +DE G DLL K L +P +RI+A AL H YF++ Sbjct: 231 LPKYDPNFTVYEPLPWESFLKGLDESGIDLLSKMLKLDPNQRITAKQALEHAYFKE 286 >4NST-A nrPDB Length = 351 Score = 308 bits (788), Expect = 3e-84, Method: Composition-based stats. Identities = 123/333 (36%), Positives = 181/333 (54%), Gaps = 17/333 (5%) Query: 2 EKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIRE 61 E D R +++ + IGEG YG+V+KA+D K+ G VALK+VR+ +EG P++ IRE Sbjct: 4 ESDWGKRCVDKFDIIGIIGEGTYGQVYKAKD-KDTGELVALKKVRLDNEKEGFPITAIRE 62 Query: 62 VAVLRHLETFEHPNVVRLFDVCTVSR-----TDRETKLTLVFEHVDQDLTTYLDKVPEPG 116 + +LR L H +VV + ++ T + + LVFE++D DL L+ Sbjct: 63 IKILRQL---IHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGL-VH 118 Query: 117 VPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYS--FQM 174 + IK M QL+ GL++ H +HRD+K NIL+ +SGQIKLADFGLAR+Y+ Sbjct: 119 FSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESR 178 Query: 175 ALTSVVVTLWYRAPEVLLQ-SSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILD 233 T+ V+TLWYR PE+LL Y +D+WS GCI E+F +KP+F+ + ++ QL I Sbjct: 179 PYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISR 238 Query: 234 VIGLPGEEDWPRDVALPRQAFHSKSAQ---PIEKFVTDIDELGKDLLLKCLTFNPAKRIS 290 + G P WP + LP Q + + + I DLL LT +P+KR + Sbjct: 239 LCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCT 298 Query: 291 AYSALSHPYFQDLERCKENLDSHLPPSQNTSEL 323 A L + +D+E K LP Q+ EL Sbjct: 299 AEQTLQSDFLKDVELSK-MAPPDLPHWQDCHEL 330 >5EFQ-A nrPDB Length = 347 Score = 306 bits (785), Expect = 6e-84, Method: Composition-based stats. Identities = 122/333 (36%), Positives = 176/333 (52%), Gaps = 17/333 (5%) Query: 2 EKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIRE 61 + D R +++ + IGEG YG+V+KARD K+ G VALK+VR+ +EG P++ IRE Sbjct: 2 DIDWGKRCVDKFDIIGIIGEGTYGQVYKARD-KDTGEMVALKKVRLDNEKEGFPITAIRE 60 Query: 62 VAVLRHLETFEHPNVVRLFDVCTVSR-----TDRETKLTLVFEHVDQDLTTYLDKVPEPG 116 + +LR L H +++ + ++ T + LVFE++D DL L+ Sbjct: 61 IKILRQL---THQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGL-VH 116 Query: 117 VPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYS--FQM 174 IK M QL+ GLD+ H +HRD+K NIL+ + GQIKLADFGLAR+YS Sbjct: 117 FNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESR 176 Query: 175 ALTSVVVTLWYRAPEVLLQ-SSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILD 233 T+ V+TLWYR PE+LL Y +D+WS GCI E+F +KP+F+ + ++ QL I Sbjct: 177 PYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISR 236 Query: 234 VIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTD---IDELGKDLLLKCLTFNPAKRIS 290 + G P WP + LP Q K + I DL L +P+KR + Sbjct: 237 ICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCT 296 Query: 291 AYSALSHPYFQDLERCKENLDSHLPPSQNTSEL 323 A AL + +D+E K LP Q+ EL Sbjct: 297 AEQALQCEFLRDVEPSK-MPPPDLPLWQDCHEL 328 >4AU8-A nrPDB Length = 296 Score = 306 bits (783), Expect = 1e-83, Method: Composition-based stats. Identities = 136/304 (44%), Positives = 182/304 (59%), Gaps = 15/304 (4%) Query: 8 RADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRH 67 Q+YE + +IGEG YG VFKA++ + VALKRVR+ +EG+P S +RE+ +L+ Sbjct: 3 MGSQKYEKLEKIGEGTYGTVFKAKN-RETHEIVALKRVRLDDDDEGVPSSALREICLLKE 61 Query: 68 LETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMF 127 L+ H N+VRL DV + KLTLVFE DQDL Y D + E +K +F Sbjct: 62 LK---HKNIVRLHDVL-----HSDKKLTLVFEFCDQDLKKYFDS-CNGDLDPEIVKSFLF 112 Query: 128 QLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSV-VVTLWYR 186 QLL+GL F HS V+HRDLKPQN+L+ +G++KLADFGLAR + + S VVTLWYR Sbjct: 113 QLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYR 172 Query: 187 APEVLLQSS-YATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILDVIGLPGEEDWP 244 P+VL + Y+T +D+WS GCIFAE+ +PLF G+ DQL +I ++G P EE WP Sbjct: 173 PPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWP 232 Query: 245 RDVALPRQAFHS--KSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQD 302 LP + + + V ++ G+DLL L NP +RISA AL HPYF D Sbjct: 233 SMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 292 Query: 303 LERC 306 Sbjct: 293 FCPP 296 >2F9G-A nrPDB Length = 353 Score = 303 bits (777), Expect = 6e-83, Method: Composition-based stats. Identities = 114/336 (33%), Positives = 174/336 (51%), Gaps = 26/336 (7%) Query: 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR 60 M K + ++ + +GEGAYG V A K G VA+K++ + L T+R Sbjct: 1 MPKRIVYNISSDFQLKSLLGEGAYGVVCSATH-KPTGEIVAIKKI-EPFDKPLFALRTLR 58 Query: 61 EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTE 120 E+ +L+H F+H N++ +F++ + ++ ++ E + DL + + + Sbjct: 59 EIKILKH---FKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVIS---TQMLSDD 112 Query: 121 TIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSF-------- 172 I+ ++Q LR + LH V+HRDLKP N+L+ S+ +K+ DFGLARI Sbjct: 113 HIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEP 172 Query: 173 ---QMALTSVVVTLWYRAPEVLLQS-SYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQL 228 Q +T V T WYRAPEV+L S Y+ +D+WS GCI AE+F R+P+F G QL Sbjct: 173 TGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQL 232 Query: 229 GKILDVIGLPGEEDWPRDVALPRQAFHSKSAQ-----PIEKFVTDIDELGKDLLLKCLTF 283 I +IG P ++ R + PR + KS P+EK ++ G DLL + L F Sbjct: 233 LLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVF 292 Query: 284 NPAKRISAYSALSHPYFQDLERCKENLD-SHLPPSQ 318 +PAKRI+A AL HPY Q + + +PPS Sbjct: 293 DPAKRITAKEALEHPYLQTYHDPNDEPEGEPIPPSF 328 >4KRC-A nrPDB Length = 317 Score = 301 bits (770), Expect = 4e-82, Method: Composition-based stats. Identities = 124/309 (40%), Positives = 180/309 (58%), Gaps = 23/309 (7%) Query: 7 CRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLR 66 + Q++ + ++G G Y V+K + K G +VALK V++ + EEG P + IRE+++++ Sbjct: 1 MSSSSQFKQLEKLGNGTYATVYKGLN-KTTGVYVALKEVKLDS-EEGTPSTAIREISLMK 58 Query: 67 HLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVP----EPGVPTETI 122 L+ H N+VRL+DV E KLTLVFE +D DL Y+D G+ + Sbjct: 59 ELK---HENIVRLYDVIHT-----ENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLV 110 Query: 123 KDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMA-LTSVVV 181 K +QLL+GL F H ++++HRDLKPQN+L+ GQ+KL DFGLAR + + +S VV Sbjct: 111 KYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVV 170 Query: 182 TLWYRAPEVLLQ-SSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGE 240 TLWYRAP+VL+ +Y+T +D+WS GCI AEM KPLF G++D +QL I D++G P E Sbjct: 171 TLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNE 230 Query: 241 EDWPRDVALPRQAFHSKSAQPIE-------KFVTDIDELGKDLLLKCLTFNPAKRISAYS 293 WP LP+ + + P + +D D L L NP R+SA Sbjct: 231 SLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQ 290 Query: 294 ALSHPYFQD 302 AL HP+F + Sbjct: 291 ALHHPWFAE 299 >6DTL-A nrPDB Length = 364 Score = 297 bits (760), Expect = 5e-81, Method: Composition-based stats. Identities = 106/304 (34%), Positives = 165/304 (54%), Gaps = 10/304 (3%) Query: 16 VAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPN 75 + IG+GAYG V A + + VA+K++ + T+RE+ +LRH+ +H N Sbjct: 35 IMPIGKGAYGIVCSAMNSETN-ESVAIKKIANAFDNKIDAKRTLREIKLLRHM---DHEN 90 Query: 76 VVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDF 135 +V + D+ + + + +E +D DL + + E + ++Q+LRGL + Sbjct: 91 IVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRS--NQALSEEHCQYFLYQILRGLKY 148 Query: 136 LHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSS 195 +HS V+HRDLKP N+L+ ++ +K+ DFGLAR+ S +T VVT WYRAPE+LL SS Sbjct: 149 IHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSS 208 Query: 196 -YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAF 254 Y +D+WSVGCIF E+ RKPLF G V QL ++++IG P EE+ ++ Sbjct: 209 DYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYI 268 Query: 255 HSKSAQPIEKF---VTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLD 311 P + + L DL+ K LTF+P +RI+ AL+HPY L + + Sbjct: 269 RQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISDEPE 328 Query: 312 SHLP 315 +P Sbjct: 329 CTIP 332 >1CM8-A nrPDB Length = 367 Score = 295 bits (756), Expect = 2e-80, Method: Composition-based stats. Identities = 106/307 (34%), Positives = 159/307 (51%), Gaps = 15/307 (4%) Query: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 Y + +G GAYG V A D + G + VA+K++ E RE+ +L+H+ Sbjct: 27 YRDLQPVGSGAYGAVCSAVDGRTGAK-VAIKKLYRPFQSELFAKRAYRELRLLKHMR--- 82 Query: 73 HPNVVRLFDVCTVSRT-DRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLR 131 H NV+ L DV T T D T LV + DL + + + I+ +++Q+L+ Sbjct: 83 HENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMK---HEKLGEDRIQFLVYQMLK 139 Query: 132 GLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVL 191 GL ++H+ ++HRDLKP N+ V ++K+ DFGLAR +T VVT WYRAPEV+ Sbjct: 140 GLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLAR--QADSEMTGYVVTRWYRAPEVI 197 Query: 192 LQ-SSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALP 250 L Y VD+WSVGCI AEM K LF+GS +DQL +I+ V G P E R + Sbjct: 198 LNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDE 257 Query: 251 RQAF----HSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERC 306 + + + +T+ L +LL K L + +R++A AL+HPYF+ L Sbjct: 258 AKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDT 317 Query: 307 KENLDSH 313 ++ Sbjct: 318 EDEPQVQ 324 >5Z33-A nrPDB Length = 425 Score = 295 bits (755), Expect = 2e-80, Method: Composition-based stats. Identities = 104/317 (32%), Positives = 160/317 (50%), Gaps = 16/317 (5%) Query: 8 RADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRH 67 D++Y E+G+GAYG V A + + VA+K+V ++ + +RE+ +L+H Sbjct: 28 IVDERYTVTKELGQGAYGIVCAAVNNQTS-EGVAIKKVTNVFSKKILAKRALREIKLLQH 86 Query: 68 LETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMF 127 H N+ L+D + R D + L E ++ DL + + + ++ Sbjct: 87 FRG--HRNITCLYD-MDIPRPDNFNETYLYEELMECDLAAIIRS--GQPLTDAHFQSFIY 141 Query: 128 QLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMA-----LTSVVVT 182 Q+L GL ++HS V+HRDLKP N+LV + ++K+ DFGLAR +S +T V T Sbjct: 142 QILCGLKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSVDPEENAGYMTEYVAT 201 Query: 183 LWYRAPEV-LLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEE 241 WYRAPE+ L SY +D+WSVGCI AE+ +P F+G VDQL +IL ++G P EE Sbjct: 202 RWYRAPEIMLSFQSYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQILHILGTPNEE 261 Query: 242 DWPRDVALPRQAFHSK----SAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSH 297 R + Q + + +P + + DLL + L F+P+ RIS AL H Sbjct: 262 TLSRIGSPRAQEYVRNLPFMAKKPFPTLFPNANPDALDLLDRMLAFDPSSRISVEQALEH 321 Query: 298 PYFQDLERCKENLDSHL 314 PY + D Sbjct: 322 PYLHIWHDASDEPDCPT 338 >4MYG-A nrPDB Length = 372 Score = 294 bits (754), Expect = 3e-80, Method: Composition-based stats. Identities = 109/303 (35%), Positives = 156/303 (51%), Gaps = 16/303 (5%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVR 78 +G GAYG V A D ++G + VA+K++ E RE+ +L+H++ H NV+ Sbjct: 51 VGSGAYGSVCSAIDKRSGEK-VAIKKLSRPFQSEIFAKRAYRELLLLKHMQ---HENVIG 106 Query: 79 LFDVCTV-SRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLH 137 L DV T S LV + DL K+ E I+ +++Q+L+GL ++H Sbjct: 107 LLDVFTPASSLRNFYDFYLVMPFMQTDL----QKIMGMEFSEEKIQYLVYQMLKGLKYIH 162 Query: 138 SHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQ-SSY 196 S VVHRDLKP N+ V ++K+ DFGLAR +T VVT WYRAPEV+L Y Sbjct: 163 SAGVVHRDLKPGNLAVNEDCELKILDFGLAR--HADAEMTGYVVTRWYRAPEVILSWMHY 220 Query: 197 ATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDW----PRDVALPRQ 252 VD+WSVGCI AEM K LF+G +DQL +IL V G+PG E + Q Sbjct: 221 NQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQ 280 Query: 253 AFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDS 312 + + + DLL K L + KR++A AL+HP+F+ +E ++ Sbjct: 281 SLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEETEA 340 Query: 313 HLP 315 P Sbjct: 341 QQP 343 >4QNY-A nrPDB Length = 354 Score = 293 bits (751), Expect = 6e-80, Method: Composition-based stats. Identities = 106/310 (34%), Positives = 160/310 (51%), Gaps = 12/310 (3%) Query: 6 LCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGM-PLSTIREVAV 64 +CR D +Y IG G+YG V +ARD K+ R VA+KRV + EE + +RE+ + Sbjct: 15 VCRLDDRYLLERIIGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFEEVILAKRILREIKL 74 Query: 65 LRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKD 124 L H F N++ L ++ T + +V + ++ DL L E + I+ Sbjct: 75 LAH---FNDDNIIGLRNILTPEDPENFDHFYIVMDIMETDLKQVLRSGQE--LTEAHIQF 129 Query: 125 MMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMA-LTSVVVTL 183 ++Q LR L +HS V+HRD+ P NILV ++ +K+ DFGLA+ + Q +T V Sbjct: 130 FIYQALRALHIIHSAGVIHRDITPANILVNTNCDLKICDFGLAKEENDQGEYMTDYVTMR 189 Query: 184 WYRAPE-VLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEED 242 WYRAPE V+ Y+ +D+W +GCI E+ +PLF+G V+QL KI+DVIG P EED Sbjct: 190 WYRAPELVMEDKDYSAQIDVWGIGCILGELLGSRPLFQGKDRVNQLDKIVDVIGTPSEED 249 Query: 243 WPRDVALPRQAFHSKSAQ----PIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHP 298 + Q + K + + DLL L FNP +RI+ A+ HP Sbjct: 250 INSVGSSAAQKYLKKKSHRPQADWRQRYPTASPEALDLLRHMLVFNPKRRITVLQAMRHP 309 Query: 299 YFQDLERCKE 308 + + L + Sbjct: 310 FLEQLHDDAD 319 >4EWQ-A nrPDB Length = 383 Score = 290 bits (743), Expect = 5e-79, Method: Composition-based stats. Identities = 108/315 (34%), Positives = 162/315 (51%), Gaps = 16/315 (5%) Query: 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR 60 + K ++Y+ ++ +G GAYG V A D K G R VA+K++ T R Sbjct: 36 LNKTIWEVP-ERYQNLSPVGSGAYGSVCAAFDTKTGLR-VAVKKLSRPFQSIIHAKRTYR 93 Query: 61 EVAVLRHLETFEHPNVVRLFDVCTVSRT-DRETKLTLVFEHVDQDLTTYLDKVPEPGVPT 119 E+ +L+H++ H NV+ L DV T +R+ + + LV + DL V + Sbjct: 94 ELRLLKHMK---HENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNN---IVKCQKLTD 147 Query: 120 ETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSV 179 + ++ +++Q+LRGL ++HS ++HRDLKP N+ V ++K+ DFGLAR +T Sbjct: 148 DHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDEMTGY 205 Query: 180 VVTLWYRAPEVLLQ-SSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLP 238 V T WYRAPE++L Y VD+WSVGCI AE+ + LF G+ +DQL IL ++G P Sbjct: 206 VATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTP 265 Query: 239 GEEDWPR-DVALPRQAFHSKSAQPIEKFVT---DIDELGKDLLLKCLTFNPAKRISAYSA 294 G E + R S + P F + L DLL K L + KRI+A A Sbjct: 266 GAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQA 325 Query: 295 LSHPYFQDLERCKEN 309 L+H YF + Sbjct: 326 LAHAYFAQYHDPDDE 340 >4QTB-A nrPDB Length = 380 Score = 289 bits (740), Expect = 1e-78, Method: Composition-based stats. Identities = 110/313 (35%), Positives = 162/313 (51%), Gaps = 17/313 (5%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETF 71 +Y + IGEGAYG V A D R VA+K++ + T+RE+ +L F Sbjct: 42 RYTQLQYIGEGAYGMVSSAYDHVRKTR-VAIKKIS-PFEHQTYCQRTLREIQIL---LRF 96 Query: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLR 131 H NV+ + D+ S + + +V + ++ DL L + + I ++Q+LR Sbjct: 97 RHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKS---QQLSNDHICYFLYQILR 153 Query: 132 GLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARI----YSFQMALTSVVVTLWYRA 187 GL ++HS V+HRDLKP N+L+ ++ +K+ DFGLARI + LT V T WYRA Sbjct: 154 GLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRA 213 Query: 188 PEV-LLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRD 246 PE+ L Y +D+WSVGCI AEM +P+F G +DQL IL ++G P +ED Sbjct: 214 PEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 273 Query: 247 VALPR----QAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQD 302 + + Q+ SK+ K D DLL + LTFNP KRI+ AL+HPY + Sbjct: 274 INMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQ 333 Query: 303 LERCKENLDSHLP 315 + + P Sbjct: 334 YYDPTDEPVAEEP 346 >4AGU-A nrPDB Length = 311 Score = 289 bits (739), Expect = 1e-78, Method: Composition-based stats. Identities = 108/315 (34%), Positives = 174/315 (55%), Gaps = 16/315 (5%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 ++YE + +IGEG+YG VFK R+ ++ G+ VA+K+ + + +RE+ +L+ L+ Sbjct: 3 EKYEKIGKIGEGSYGVVFKCRN-RDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLK- 60 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130 HPN+V L +V R+ +L LVFE+ D + LD+ GVP +K + +Q L Sbjct: 61 --HPNLVNLLEVF-----RRKRRLHLVFEYCDHTVLHELDRYQR-GVPEHLVKSITWQTL 112 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYS-FQMALTSVVVTLWYRAPE 189 + ++F H H +HRD+KP+NIL+T IKL DFG AR+ + V T WYR+PE Sbjct: 113 QAVNFCHKHNCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYDDEVATRWYRSPE 172 Query: 190 VLLQSS-YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIG--LPGEEDWPRD 246 +L+ + Y PVD+W++GC+FAE+ PL+ G SDVDQL I +G +P + Sbjct: 173 LLVGDTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFST 232 Query: 247 VALPR--QAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLE 304 + + +P+E +I LL CL +P +R++ L HPYF+++ Sbjct: 233 NQYFSGVKIPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTERLTCEQLLHHPYFENIR 292 Query: 305 RCKENLDSHLPPSQN 319 ++ H P++N Sbjct: 293 EIEDLAKEHDKPAEN 307 >5NGU-A nrPDB Length = 381 Score = 288 bits (738), Expect = 2e-78, Method: Composition-based stats. Identities = 108/313 (34%), Positives = 163/313 (52%), Gaps = 17/313 (5%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETF 71 +Y ++ IGEGAYG V A D N R VA+K++ + T+RE+ +L F Sbjct: 43 RYTNLSYIGEGAYGMVCSAYDNLNKVR-VAIKKIS-PFEHQTYCQRTLREIKIL---LRF 97 Query: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLR 131 H N++ + D+ ++ + +V + ++ DL L + + I ++Q+LR Sbjct: 98 RHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLK---TQHLSNDHICYFLYQILR 154 Query: 132 GLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMA----LTSVVVTLWYRA 187 GL ++HS V+HRDLKP N+L+ ++ +K+ DFGLAR+ LT V T WYRA Sbjct: 155 GLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRA 214 Query: 188 PEV-LLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRD 246 PE+ L Y +D+WSVGCI AEM +P+F G +DQL IL ++G P +ED Sbjct: 215 PEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 274 Query: 247 VALPRQAF----HSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQD 302 + L + + K+ P + + D DLL K LTFNP KRI AL+HPY + Sbjct: 275 INLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQ 334 Query: 303 LERCKENLDSHLP 315 + + P Sbjct: 335 YYDPSDEPIAEAP 347 >3OHT-A nrPDB Length = 389 Score = 288 bits (738), Expect = 2e-78, Method: Composition-based stats. Identities = 101/319 (31%), Positives = 168/319 (52%), Gaps = 16/319 (5%) Query: 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR 60 + K ++Y+ ++ +G GAYG V + D+K+G + +A+K++ T R Sbjct: 42 LNKTIWEVP-ERYQTLSPVGSGAYGSVCSSYDVKSGLK-IAVKKLSRPFQSIIHAKRTYR 99 Query: 61 EVAVLRHLETFEHPNVVRLFDVCTVSRT-DRETKLTLVFEHVDQDLTTYLDKVPEPGVPT 119 E+ +L+H++ H NV+ L DV T + + + + LV + DL V + Sbjct: 100 ELRLLKHMK---HENVIGLLDVFTPATSLEEFNDVYLVTHLMGADLNN---IVKCQKLTD 153 Query: 120 ETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSV 179 + ++ +++Q+LRGL ++HS ++HRDLKP N+ V ++K+ DFGLAR +T Sbjct: 154 DHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDEMTGY 211 Query: 180 VVTLWYRAPEVLLQ-SSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLP 238 V T WYRAPE++L Y VD+WSVGCI AE+ + LF G+ ++QL +I+ + G P Sbjct: 212 VATRWYRAPEIMLNWMHYNMTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTP 271 Query: 239 GEEDWPRDVALPRQAFHSKSAQPIEKFVTDI----DELGKDLLLKCLTFNPAKRISAYSA 294 R + + + + Q ++ D+ + L DLL K L + KRI+A A Sbjct: 272 PASVISRMPSHEARNYINSLPQMPKRNFADVFIGANPLAVDLLEKMLVLDTDKRITASEA 331 Query: 295 LSHPYFQDLERCKENLDSH 313 L+HPYF + +S Sbjct: 332 LAHPYFSQYHDPDDEPESE 350 >1UA2-A nrPDB Length = 346 Score = 287 bits (736), Expect = 3e-78, Method: Composition-based stats. Identities = 115/311 (36%), Positives = 172/311 (55%), Gaps = 18/311 (5%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRV---QTGEEGMPLSTIREVAVLRH 67 ++YE + +GEG + V+KARD KN + VA+K++++ ++G+ + +RE+ +L+ Sbjct: 10 KRYEKLDFLGEGQFATVYKARD-KNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 Query: 68 LETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMF 127 L HPN++ L D ++ ++LVF+ ++ DL + K + IK M Sbjct: 69 LS---HPNIIGLLDAF-----GHKSNISLVFDFMETDL-EVIIKDNSLVLTPSHIKAYML 119 Query: 128 QLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY-SFQMALTSVVVTLWYR 186 L+GL++LH H ++HRDLKP N+L+ +G +KLADFGLA+ + S A T VVT WYR Sbjct: 120 MTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYR 179 Query: 187 APEVLLQ-SSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPR 245 APE+L Y VD+W+VGCI AE+ R P G SD+DQL +I + +G P EE WP Sbjct: 180 APELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPD 239 Query: 246 DVALPRQ-AFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLE 304 +LP F S P+ + + DL+ FNP RI+A AL YF + Sbjct: 240 MCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSN-- 297 Query: 305 RCKENLDSHLP 315 R LP Sbjct: 298 RPGPTPGCQLP 308 >1JNK-A nrPDB Length = 423 Score = 286 bits (733), Expect = 7e-78, Method: Composition-based stats. Identities = 105/324 (32%), Positives = 152/324 (46%), Gaps = 27/324 (8%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 ++Y+ + IG GA G V A D R VA+K++ + RE+ +++ Sbjct: 62 KRYQNLKPIGSGAQGIVCAAYDAVLD-RNVAIKKLSRPFQNQTHAKRAYRELVLMK---C 117 Query: 71 FEHPNVVRLFDVCTVSRT-DRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQL 129 H N++ L +V T +T + + LV E +D +L + + E + +++Q+ Sbjct: 118 VNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ----MELDHERMSYLLYQM 173 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPE 189 L G+ LHS ++HRDLKP NI+V S +K+ DFGLAR +T VVT +YRAPE Sbjct: 174 LCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPE 233 Query: 190 VLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVAL 249 V+L Y VD+WSVGCI EM R K LF G +DQ K+++ +G P E + Sbjct: 234 VILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPT 293 Query: 250 PRQAFHSKSAQPIEKFVTDID---------------ELGKDLLLKCLTFNPAKRISAYSA 294 R ++ F +DLL K L +PAKRIS A Sbjct: 294 VRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDA 353 Query: 295 LSHPYFQDLERCKENLDSHLPPSQ 318 L HPY E PP Q Sbjct: 354 LQHPYINVWYDPAE---VEAPPPQ 374 >3FI2-A nrPDB Length = 353 Score = 283 bits (725), Expect = 6e-77, Method: Composition-based stats. Identities = 101/307 (32%), Positives = 148/307 (48%), Gaps = 24/307 (7%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 ++Y+ + IG GA G V A D R VA+K++ + RE+ +++ Sbjct: 24 KRYQNLKPIGSGAQGIVCAAYDAVLD-RNVAIKKLSRPFQNQTHAKRAYRELVLMK---C 79 Query: 71 FEHPNVVRLFDVCTVSRT-DRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQL 129 H N++ L +V T +T + + LV E +D +L + + E + +++Q+ Sbjct: 80 VNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ----MELDHERMSYLLYQM 135 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPE 189 L G+ LHS ++HRDLKP NI+V S +K+ DFGLAR +T VVT +YRAPE Sbjct: 136 LCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPE 195 Query: 190 VLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVAL 249 V+L Y VD+WSVGCI EM R K LF G +DQ K+++ +G P E + Sbjct: 196 VILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPT 255 Query: 250 PRQAFHSKSAQPIEKFVTDID---------------ELGKDLLLKCLTFNPAKRISAYSA 294 R ++ F +DLL K L +PAKRIS A Sbjct: 256 VRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDA 315 Query: 295 LSHPYFQ 301 L HPY Sbjct: 316 LQHPYIN 322 >5AWM-A nrPDB Length = 394 Score = 283 bits (724), Expect = 8e-77, Method: Composition-based stats. Identities = 96/329 (29%), Positives = 148/329 (44%), Gaps = 29/329 (8%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 +Y + IG GA G V A D + VA+K++ RE +++ Sbjct: 44 SRYINLRPIGSGAQGIVCAAYDTIT-QQNVAIKKLSRPFQNVTHAKRAYREFKLMK---L 99 Query: 71 FEHPNVVRLFDVCTVSRT-DRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQL 129 H N++ L + T R + + LV E +D +L + + + + +++Q+ Sbjct: 100 VNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQ----MDLDHDRMSYLLYQM 155 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPE 189 L G+ LHS ++HRDLKP NI+V + +K+ DFGLAR +T VVT +YRAPE Sbjct: 156 LCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPE 215 Query: 190 VLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVAL 249 V+L Y VD+WSVGCI EM R LF G+ +DQ KI++ +G P R Sbjct: 216 VILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPT 275 Query: 250 PRQAFHSKSAQ---------PIEKFVTDIDE-------LGKDLLLKCLTFNPAKRISAYS 293 R ++ P F D ++ ++LL K L +P +RIS Sbjct: 276 VRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDE 335 Query: 294 ALSHPYFQDLERCKENLDSHLPPSQNTSE 322 AL H Y + + P+ + Sbjct: 336 ALKHEYIN----VWYDAEEVDAPAPEPYD 360 >2XS0-A nrPDB Length = 386 Score = 282 bits (723), Expect = 1e-76, Method: Composition-based stats. Identities = 97/325 (29%), Positives = 154/325 (47%), Gaps = 25/325 (7%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 ++Y+ + IG GA G V A D R VA+K++ + RE+ +++ Sbjct: 26 KRYQNLKPIGSGAQGIVCAAYDAIL-ERNVAIKKLSRPFQNQTHAKRAYRELVLMK---C 81 Query: 71 FEHPNVVRLFDVCTVSRT-DRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQL 129 H N++ L +V T ++ + + +V E +D +L + + E + +++Q+ Sbjct: 82 VNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ----MELDHERMSYLLYQM 137 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPE 189 L G+ LHS ++HRDLKP NI+V S +K+ DFGLAR + VVT +YRAPE Sbjct: 138 LCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMVPFVVTRYYRAPE 197 Query: 190 VLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVAL 249 V+L Y VD+WSVGCI EM + LF G+ +DQ K+++ +G P E + Sbjct: 198 VILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQPT 257 Query: 250 PRQAFHSKSAQP---IEKFVTDI------------DELGKDLLLKCLTFNPAKRISAYSA 294 R ++ EK D+ +DLL K L + +KRIS A Sbjct: 258 VRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEA 317 Query: 295 LSHPYFQDLERCKENLDSHLPPSQN 319 L HPY + ++ P + Sbjct: 318 LQHPYIN-VWYDPSEAEAPPPKIPD 341 >3GC9-A nrPDB Length = 370 Score = 282 bits (722), Expect = 1e-76, Method: Composition-based stats. Identities = 104/328 (31%), Positives = 166/328 (50%), Gaps = 18/328 (5%) Query: 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR 60 + K Q+ + + +G GAYG V A D + + VA+K++ T R Sbjct: 19 LNKTVWEVP-QRLQGLRPVGSGAYGSVCSAYDARLRQK-VAVKKLSRPFQSLIHARRTYR 76 Query: 61 EVAVLRHLETFEHPNVVRLFDVCTVSRT-DRETKLTLVFEHVDQDLTTYLDKVPEPGVPT 119 E+ +L+HL+ H NV+ L DV T + + + +++ LV + DL V + Sbjct: 77 ELRLLKHLK---HENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNN---IVKSQALSD 130 Query: 120 ETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSV 179 E ++ +++QLLRGL ++HS ++HRDLKP N+ V ++++ DFGLAR +T Sbjct: 131 EHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDSELRILDFGLAR--QADEEMTGY 188 Query: 180 VVTLWYRAPEVLLQ-SSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLP 238 V T WYRAPE++L Y VD+WSVGCI AE+ + K LF GS +DQL +I++V+G P Sbjct: 189 VATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTP 248 Query: 239 GEEDW----PRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSA 294 E Q+ + + + L DLL + L + +R+SA A Sbjct: 249 SPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEA 308 Query: 295 LSHPYFQDLERCKENLDSHLPPSQNTSE 322 L+H YF ++ ++ P + E Sbjct: 309 LAHAYFSQYHDPEDEPEAE--PYDESVE 334 >3LIJ-A nrPDB Length = 494 Score = 282 bits (721), Expect = 2e-76, Method: Composition-based stats. Identities = 92/317 (29%), Positives = 146/317 (46%), Gaps = 40/317 (12%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLE 69 + Y+ V ++G GAYG+V RD A+K +R + + EVAVL+ L Sbjct: 36 SEMYQRVKKLGSGAYGEVLLCRDKVTHVER-AIKIIRKTSVSTSSNSKLLEEVAVLKLL- 93 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFE-HVDQDLTTYLDKVPEPGVPTETIKDMMFQ 128 +HPN+++L+D R LV E + +L + + ++ Q Sbjct: 94 --DHPNIMKLYDFFEDKRN-----YYLVMECYKGGELFDEI--IHRMKFNEVDAAVIIKQ 144 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTS---SGQIKLADFGLARIYSFQMALTSVVVTLWY 185 +L G+ +LH H +VHRDLKP+N+L+ S IK+ DFGL+ ++ Q + + T +Y Sbjct: 145 VLSGVTYLHKHNIVHRDLKPENLLLESKEKDALIKIVDFGLSAVFENQKKMKERLGTAYY 204 Query: 186 RAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPR 245 APEVL + Y D+WS+G I + P F G +D + L K+ +W Sbjct: 205 IAPEVL-RKKYDEKCDVWSIGVILFILLAGYPPFGGQTDQEILRKVEKGKYTFDSPEWK- 262 Query: 246 DVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLER 305 ++ E KDL+ + L F+ +RISA AL HP+ +++ Sbjct: 263 ----------------------NVSEGAKDLIKQMLQFDSQRRISAQQALEHPWIKEMCS 300 Query: 306 CKENLDSHLPPSQNTSE 322 KE+ LP N E Sbjct: 301 KKES-GIELPSLANAIE 316 >3E7O-A nrPDB Length = 360 Score = 282 bits (721), Expect = 2e-76, Method: Composition-based stats. Identities = 105/324 (32%), Positives = 157/324 (48%), Gaps = 27/324 (8%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 ++Y+ + IG GA G V A D G VA+K++ + RE+ +L+ Sbjct: 22 KRYQQLKPIGSGAQGIVCAAFDTVL-GINVAVKKLSRPFQNQTHAKRAYRELVLLK---C 77 Query: 71 FEHPNVVRLFDVCTVSRT-DRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQL 129 H N++ L +V T +T + + LV E +D +L + + E + +++Q+ Sbjct: 78 VNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI----HMELDHERMSYLLYQM 133 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPE 189 L G+ LHS ++HRDLKP NI+V S +K+ DFGLAR S +T VVT +YRAPE Sbjct: 134 LCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTASTNFMMTPYVVTRYYRAPE 193 Query: 190 VLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVAL 249 V+L Y VD+WSVGCI E+ + +F+G+ +DQ K+++ +G P E Sbjct: 194 VILGMGYKENVDIWSVGCIMGELVKGSVIFQGTDHIDQWNKVIEQLGTPSAEFMAALQPT 253 Query: 250 PRQAFHSKSAQP---IEKFVTDI------------DELGKDLLLKCLTFNPAKRISAYSA 294 R ++ A P E+ D +DLL K L +P KRIS A Sbjct: 254 VRNYVENRPAYPGIAFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEA 313 Query: 295 LSHPYFQDLERCKENLDSHLPPSQ 318 L HPY E + PP Q Sbjct: 314 LRHPYITVWYDPAE---AEAPPPQ 334 >4IC8-A nrPDB Length = 442 Score = 281 bits (720), Expect = 2e-76, Method: Composition-based stats. Identities = 106/316 (33%), Positives = 159/316 (50%), Gaps = 17/316 (5%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 +YE + IG GAYG V AR + G+ VA+K++ T+RE+ +L+H Sbjct: 55 DEYEIIETIGNGAYGVVSSAR-RRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKH--- 110 Query: 71 FEHPNVVRLFDVCTVS-RTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQL 129 F+H N++ + D+ + + +V + ++ DL + + E ++ ++QL Sbjct: 111 FKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSS--QPLTLEHVRYFLYQL 168 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY-----SFQMALTSVVVTLW 184 LRGL ++HS +V+HRDLKP N+LV + ++K+ DFG+AR Q +T V T W Sbjct: 169 LRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRW 228 Query: 185 YRAPEVLLQ-SSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDW 243 YRAPE++L Y +DLWSVGCIF EM R+ LF G + V QL I+ V+G P Sbjct: 229 YRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVI 288 Query: 244 P----RDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPY 299 V Q+ + P E D LL + L F P+ RISA +AL HP+ Sbjct: 289 QAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPF 348 Query: 300 FQDLERCKENLDSHLP 315 + D P Sbjct: 349 LAKYHDPDDEPDCAPP 364 >4BBM-A nrPDB Length = 331 Score = 281 bits (718), Expect = 4e-76, Method: Composition-based stats. Identities = 106/297 (35%), Positives = 166/297 (55%), Gaps = 16/297 (5%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 ++YE + +GEG+YG V K R+ K+ GR VA+K+ ++ + +RE+ +L+ L Sbjct: 25 EKYENLGLVGEGSYGMVMKCRN-KDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLR- 82 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130 H N+V L +VC ++ + LVFE VD + L+ P G+ + ++ +FQ++ Sbjct: 83 --HENLVNLLEVCK-----KKKRWYLVFEFVDHTILDDLELFPN-GLDYQVVQKYLFQII 134 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY-SFQMALTSVVVTLWYRAPE 189 G+ F HSH ++HRD+KP+NILV+ SG +KL DFG AR + V T WYRAPE Sbjct: 135 NGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYDDEVATRWYRAPE 194 Query: 190 VLLQS-SYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIG--LPGEEDWPRD 246 +L+ Y VD+W++GC+ EMF +PLF G SD+DQL I+ +G +P ++ Sbjct: 195 LLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNK 254 Query: 247 VALPR--QAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQ 301 + + K +P+E+ + E+ DL KCL +P KR L H +FQ Sbjct: 255 NPVFAGVRLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQ 311 >5JN2-A nrPDB Length = 525 Score = 279 bits (715), Expect = 9e-76, Method: Composition-based stats. Identities = 83/319 (26%), Positives = 145/319 (45%), Gaps = 42/319 (13%) Query: 8 RADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRV-RVQTGEEGMPLSTIREVAVLR 66 +Y+ +G+G++G+V +D G A+K + + Q ++ S +REV +L+ Sbjct: 64 IFSDRYKGQRVLGKGSFGEVILCKDKITGQE-CAVKVISKRQVKQKTDKESLLREVQLLK 122 Query: 67 HLETFEHPNVVRLFDVCTVSRTDRETKLTLVFE-HVDQDLTTYLDKVPEPGVPTETIKDM 125 L +HPN+++L++ + + LV E + +L + + + Sbjct: 123 QL---DHPNIMKLYEFF-----EDKGYFYLVGEVYTGGELFDEI--ISRKRFSEVDAARI 172 Query: 126 MFQLLRGLDFLHSHRVVHRDLKPQNILVTS---SGQIKLADFGLARIYSFQMALTSVVVT 182 + Q+L G+ ++H +++VHRDLKP+N+L+ S I++ DFGL+ + + + T Sbjct: 173 IRQVLSGITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGT 232 Query: 183 LWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEED 242 +Y APEVL +Y D+WS G I + P F G+++ D L K+ Sbjct: 233 AYYIAPEVLHG-TYDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFELPQ 291 Query: 243 WPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQD 302 W + + E KDL+ K LT+ P+ RISA AL H + Q Sbjct: 292 WKK-----------------------VSESAKDLIRKMLTYVPSMRISARDALDHEWIQT 328 Query: 303 LERCKENLDSHLPPSQNTS 321 KE + +P N Sbjct: 329 Y--TKEQISVDVPSLDNAI 345 >3MIA-A nrPDB Length = 351 Score = 279 bits (713), Expect = 1e-75, Method: Composition-based stats. Identities = 113/317 (35%), Positives = 168/317 (52%), Gaps = 19/317 (5%) Query: 6 LCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVL 65 C +YE +A+IG+G +G+VFKAR K G + VALK+V ++ +EG P++ +RE+ +L Sbjct: 12 FCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQK-VALKKVLMENEKEGFPITALREIKIL 70 Query: 66 RHLETFEHPNVVRLFDVCTVSRTDR---ETKLTLVFEHVDQDLTTYLDKVPEPGVPTETI 122 + L+ H NVV L ++C + + + LVF+ + DL L V I Sbjct: 71 QLLK---HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVL-VKFTLSEI 126 Query: 123 KDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY-----SFQMALT 177 K +M LL GL ++H ++++HRD+K N+L+T G +KLADFGLAR + S T Sbjct: 127 KRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYT 186 Query: 178 SVVVTLWYRAPEVLLQSS-YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIG 236 + VVTLWYR PE+LL Y P+DLW GCI AEM+ R P+ +G+++ QL I + G Sbjct: 187 NRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCG 246 Query: 237 LPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDI-----DELGKDLLLKCLTFNPAKRISA 291 E WP K + D DL+ K L +PA+RI + Sbjct: 247 SITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDS 306 Query: 292 YSALSHPYFQDLERCKE 308 AL+H +F + Sbjct: 307 DDALNHDFFWSDPMPSD 323 >4ZSG-A nrPDB Length = 347 Score = 278 bits (711), Expect = 3e-75, Method: Composition-based stats. Identities = 106/316 (33%), Positives = 159/316 (50%), Gaps = 17/316 (5%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 +YE + IG GAYG V AR + G+ VA+K++ T+RE+ +L+H Sbjct: 7 DEYEIIETIGNGAYGVVSSAR-RRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKH--- 62 Query: 71 FEHPNVVRLFDVCTVS-RTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQL 129 F+H N++ + D+ + + +V + ++ DL + + E ++ ++QL Sbjct: 63 FKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSS--QPLTLEHVRYFLYQL 120 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY-----SFQMALTSVVVTLW 184 LRGL ++HS +V+HRDLKP N+LV + ++K+ DFG+AR Q +T V T W Sbjct: 121 LRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRW 180 Query: 185 YRAPEVLLQ-SSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDW 243 YRAPE++L Y +DLWSVGCIF EM R+ LF G + V QL I+ V+G P Sbjct: 181 YRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVI 240 Query: 244 P----RDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPY 299 V Q+ + P E D LL + L F P+ RISA +AL HP+ Sbjct: 241 QAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPF 300 Query: 300 FQDLERCKENLDSHLP 315 + D P Sbjct: 301 LAKYHDPDDEPDCAPP 316 >3NCG-A nrPDB Length = 486 Score = 278 bits (711), Expect = 3e-75, Method: Composition-based stats. Identities = 85/314 (27%), Positives = 145/314 (46%), Gaps = 40/314 (12%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 ++Y V +G+G++G+V K +D A+K + + + + +REV +L+ L Sbjct: 22 ERYNIVCMLGKGSFGEVLKCKDRITQQE-YAVKVINKASAKNKDTSTILREVELLKKL-- 78 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFE-HVDQDLTTYLDKVPEPGVPTETIKDMMFQL 129 +HPN+++LF++ S + +V E + +L + + ++ Q+ Sbjct: 79 -DHPNIMKLFEILEDS-----SSFYIVGELYTGGELFDEI--IKRKRFSEHDAARIIKQV 130 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTS---SGQIKLADFGLARIYSFQMALTSVVVTLWYR 186 G+ ++H H +VHRDLKP+NIL+ S IK+ DFGL+ + + + T +Y Sbjct: 131 FSGITYMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYI 190 Query: 187 APEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRD 246 APEVL +Y D+WS G I + P F G ++ D L ++ E Sbjct: 191 APEVLRG-TYDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRV---------ETGKYA 240 Query: 247 VALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERC 306 LP+ I + KDL+ K LTF+P+ RI+A L HP+ Q Sbjct: 241 FDLPQ--------------WRTISDDAKDLIRKMLTFHPSLRITATQCLEHPWIQKYSSE 286 Query: 307 KENLDSHLPPSQNT 320 + S LP ++ Sbjct: 287 TPTI-SDLPSLESA 299 >3OZ6-A nrPDB Length = 388 Score = 277 bits (709), Expect = 4e-75, Method: Composition-based stats. Identities = 110/345 (31%), Positives = 166/345 (48%), Gaps = 52/345 (15%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETF 71 +YE V ++G+GAYG V+K+ D + G VA+K++ T RE+ +L L Sbjct: 10 KYELVKKLGKGAYGIVWKSIDRRT-GEVVAVKKIFDAFQNSTDAQRTFREIMILTELSG- 67 Query: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLR 131 H N+V L +V R D + + LVF++++ DL + + + +++QL++ Sbjct: 68 -HENIVNLLNVL---RADNDRDVYLVFDYMETDLHAVIRANI---LEPVHKQYVVYQLIK 120 Query: 132 GLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY--------------------- 170 + +LHS ++HRD+KP NIL+ + +K+ADFGL+R + Sbjct: 121 VIKYLHSGGLLHRDMKPSNILLNAECHVKVADFGLSRSFVNIRRVTNNIPLSINENTENF 180 Query: 171 -SFQMALTSVVVTLWYRAPEVLLQS-SYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQL 228 Q LT V T WYRAPE+LL S Y +D+WS+GCI E+ KP+F GSS ++QL Sbjct: 181 DDDQPILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGKPIFPGSSTMNQL 240 Query: 229 GKILDVIGLPGEEDWPRDVAL--------------PRQAFHSKSAQPIEKFV------TD 268 +I+ VI P ED + RQ+ + + D Sbjct: 241 ERIIGVIDFPSNEDVESIQSPFAKTMIESLKEKVEIRQSNKRDIFTKWKNLLLKINPKAD 300 Query: 269 IDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSH 313 +E DLL K L FNP KRISA AL HP+ E + Sbjct: 301 CNEEALDLLDKLLQFNPNKRISANDALKHPFVSIFHNPNEEPNCD 345 >4MVF-A nrPDB Length = 506 Score = 276 bits (707), Expect = 7e-75, Method: Composition-based stats. Identities = 79/308 (25%), Positives = 137/308 (44%), Gaps = 41/308 (13%) Query: 8 RADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRH 67 + + +Y ++G+G YG V+K D K + A+K + + +E+ +++ Sbjct: 54 KLEDKYIIDEKLGQGTYGCVYKGID-KVTNQLYAIKEEKKDRLKNIN--RFFQEIEIMKK 110 Query: 68 LETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPG-VPTETIKDMM 126 L +HPN+V+L++ + + + L+ E D + E G + +M Sbjct: 111 L---DHPNIVKLYE-----TYENDNYIYLIMELCSG--RELFDSIIENGSFTEKNAATIM 160 Query: 127 FQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQ---IKLADFGLARIYSFQMALTSVVVTL 183 Q+ + +LHS +VHRDLKP+N L S + +K+ DFGL++ T+ T Sbjct: 161 KQIFSAIFYLHSLNIVHRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFTTTKAGTP 220 Query: 184 WYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDW 243 +Y AP+VL Y D+WS G I + P F G +D + L K+ E DW Sbjct: 221 YYVAPQVL-DGKYDKKCDIWSSGVIMYTLLCGYPPFYGDTDNEVLKKVKKGEFCFYENDW 279 Query: 244 PRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDL 303 I K+L+ K LT+NP +R + AL+HP+ + Sbjct: 280 GS-----------------------ISSDAKNLITKLLTYNPNERCTIEEALNHPWITQM 316 Query: 304 ERCKENLD 311 + E+++ Sbjct: 317 TKSHEHVE 324 >3DFA-A nrPDB Length = 286 Score = 273 bits (699), Expect = 7e-74, Method: Composition-based stats. Identities = 82/296 (27%), Positives = 139/296 (46%), Gaps = 39/296 (13%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 ++Y V +G+G++G+V K +D A+K + + + + +REV +L+ L Sbjct: 22 ERYNIVCMLGKGSFGEVLKCKDRITQQE-YAVKVINKASAKNKDTSTILREVELLKKL-- 78 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFE-HVDQDLTTYLDKVPEPGVPTETIKDMMFQL 129 +HPN+++LF++ S + +V E + +L + + ++ Q+ Sbjct: 79 -DHPNIMKLFEILEDS-----SSFYIVGELYTGGELFDEI--IKRKRFSEHDAARIIKQV 130 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTS---SGQIKLADFGLARIYSFQMALTSVVVTLWYR 186 G+ ++H H +VHRDLKP+NIL+ S IK+ DFGL+ + + + T +Y Sbjct: 131 FSGITYMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYI 190 Query: 187 APEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRD 246 APEVL +Y D+WS G I + P F G ++ D L ++ E Sbjct: 191 APEVLRG-TYDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRV---------ETGKYA 240 Query: 247 VALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQD 302 LP+ I + KDL+ K LTF+P+ RI+A L HP+ Q Sbjct: 241 FDLPQ--------------WRTISDDAKDLIRKMLTFHPSLRITATQCLEHPWIQK 282 >3HZT-A nrPDB Length = 467 Score = 273 bits (698), Expect = 7e-74, Method: Composition-based stats. Identities = 85/296 (28%), Positives = 136/296 (45%), Gaps = 40/296 (13%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQT-GEEGMPLSTIREVAVLRHL 68 +Y+ V ++G GAYG+V +D G A+K ++ + + + EVAVL+ L Sbjct: 3 SDRYQRVKKLGSGAYGEVLLCKDKLTGAER-AIKIIKKSSVTTTSNSGALLDEVAVLKQL 61 Query: 69 ETFEHPNVVRLFDVCTVSRTDRETKLTLVFE-HVDQDLTTYLDKVPEPGVPTETIKDMMF 127 +HPN+++L++ R LV E + +L + + +M Sbjct: 62 ---DHPNIMKLYEFFEDKRN-----YYLVMEVYRGGELFDEI--ILRQKFSEVDAAVIMK 111 Query: 128 QLLRGLDFLHSHRVVHRDLKPQNILVTSSGQ---IKLADFGLARIYSFQMALTSVVVTLW 184 Q+L G +LH H +VHRDLKP+N+L+ S + IK+ DFGL+ + + + T + Sbjct: 112 QVLSGTTYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAY 171 Query: 185 YRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWP 244 Y APEVL + Y D+WS G I + P F G +D + L ++ DW Sbjct: 172 YIAPEVL-RKKYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEKGKFSFDPPDW- 229 Query: 245 RDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 T + + K L+ LT+ P+KRISA AL+HP+ Sbjct: 230 ----------------------TQVSDEAKQLVKLMLTYEPSKRISAEEALNHPWI 263 >3GC0-A nrPDB Length = 329 Score = 272 bits (695), Expect = 2e-73, Method: Composition-based stats. Identities = 125/302 (41%), Positives = 187/302 (61%), Gaps = 21/302 (6%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 +Y + ++GEG YG+V+KA D VA+KR+R++ EEG+P + IREV++L+ L+ Sbjct: 34 DRYRRITKLGEGTYGEVYKAIDTVTN-ETVAIKRIRLEHEEEGVPGTAIREVSLLKELQ- 91 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130 H N++ L V +L L+FE+ + DL Y+DK P+ V IK ++QL+ Sbjct: 92 --HRNIIELKSVI-----HHNHRLHLIFEYAENDLKKYMDKNPD--VSMRVIKSFLYQLI 142 Query: 131 RGLDFLHSHRVVHRDLKPQNILVT-----SSGQIKLADFGLARIYSFQM-ALTSVVVTLW 184 G++F HS R +HRDLKPQN+L++ + +K+ DFGLAR + + T ++TLW Sbjct: 143 NGVNFCHSRRCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQFTHEIITLW 202 Query: 185 YRAPEVLLQ-SSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDW 243 YR PE+LL Y+T VD+WS+ CI+AEM + PLF G S++DQL KI +V+GLP + W Sbjct: 203 YRPPEILLGSRHYSTSVDIWSIACIWAEMLMKTPLFPGDSEIDQLFKIFEVLGLPDDTTW 262 Query: 244 PRDVALP--RQAFHSKSAQPIEKFV-TDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 P ALP +Q+F + +++ + +D+ G DLL L +P KRISA +AL HPYF Sbjct: 263 PGVTALPDWKQSFPKFRGKTLKRVLGALLDDEGLDLLTAMLEMDPVKRISAKNALEHPYF 322 Query: 301 QD 302 Sbjct: 323 SH 324 >4BGQ-A nrPDB Length = 304 Score = 271 bits (694), Expect = 3e-73, Method: Composition-based stats. Identities = 102/298 (34%), Positives = 161/298 (54%), Gaps = 17/298 (5%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 ++E + +GEGAYG V K R K VA+K+ + E + +T+RE+ +LR L+ Sbjct: 12 NKFEILGVVGEGAYGVVLKCRH-KETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 70 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130 N+V L + R KL LVFE+V++++ L+++P GVP E +K ++QL+ Sbjct: 71 ---ENIVELKEAF-----RRRGKLYLVFEYVEKNMLELLEEMPN-GVPPEKVKSYIYQLI 121 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMA--LTSVVVTLWYRAP 188 + + + H + +VHRD+KP+N+L++ + +KL DFG AR S V T WYR+P Sbjct: 122 KAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYDEEVATRWYRSP 181 Query: 189 EVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA 248 E+LL + Y VD+WSVGCI E+ +PLF G S++DQL I V+G E + Sbjct: 182 ELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYS 241 Query: 249 LP-----RQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQ 301 P R + +++ ++ + DL+ L +PA R L+HP FQ Sbjct: 242 NPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQ 299 >3DXN-A nrPDB Length = 287 Score = 271 bits (694), Expect = 3e-73, Method: Composition-based stats. Identities = 85/296 (28%), Positives = 136/296 (45%), Gaps = 40/296 (13%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQT-GEEGMPLSTIREVAVLRHL 68 +Y+ V ++G GAYG+V +D G A+K ++ + + + EVAVL+ L Sbjct: 20 SDRYQRVKKLGSGAYGEVLLCKDKLTGAER-AIKIIKKSSVTTTSNSGALLDEVAVLKQL 78 Query: 69 ETFEHPNVVRLFDVCTVSRTDRETKLTLVFE-HVDQDLTTYLDKVPEPGVPTETIKDMMF 127 +HPN+++L++ R LV E + +L + + +M Sbjct: 79 ---DHPNIMKLYEFFEDKRN-----YYLVMEVYRGGELFDEI--ILRQKFSEVDAAVIMK 128 Query: 128 QLLRGLDFLHSHRVVHRDLKPQNILVTSSGQ---IKLADFGLARIYSFQMALTSVVVTLW 184 Q+L G +LH H +VHRDLKP+N+L+ S + IK+ DFGL+ + + + T + Sbjct: 129 QVLSGTTYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAY 188 Query: 185 YRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWP 244 Y APEVL + Y D+WS G I + P F G +D + L ++ DW Sbjct: 189 YIAPEVL-RKKYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEKGKFSFDPPDW- 246 Query: 245 RDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 T + + K L+ LT+ P+KRISA AL+HP+ Sbjct: 247 ----------------------TQVSDEAKQLVKLMLTYEPSKRISAEEALNHPWI 280 >5G6V-A nrPDB Length = 324 Score = 270 bits (690), Expect = 7e-73, Method: Composition-based stats. Identities = 123/298 (41%), Positives = 173/298 (58%), Gaps = 16/298 (5%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 + Y + ++GEG Y V+K + VALK +R++ EEG P + IREV++L+ L+ Sbjct: 2 ETYIKLDKLGEGTYATVYKGKSKLTDN-LVALKEIRLE-HEEGAPCTAIREVSLLKDLK- 58 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130 H N+V L D+ ++ LTLVFE++D+DL YLD + +K +FQLL Sbjct: 59 --HANIVTLHDIIHTEKS-----LTLVFEYLDKDLKQYLDDCGNI-INMHNVKLFLFQLL 110 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYS-FQMALTSVVVTLWYRAPE 189 RGL + H +V+HRDLKPQN+L+ G++KLADFGLAR S + VVTLWYR P+ Sbjct: 111 RGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYDNEVVTLWYRPPD 170 Query: 190 VLLQSS-YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWP---R 245 +LL S+ Y+T +D+W VGCIF EM +PLF GS+ +QL I ++G P EE WP Sbjct: 171 ILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILS 230 Query: 246 DVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDL 303 + + A+ + +D G DLL K L F RISA A+ HP+F L Sbjct: 231 NEEFKTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSL 288 >3MA6-A nrPDB Length = 298 Score = 269 bits (688), Expect = 1e-72, Method: Composition-based stats. Identities = 79/305 (25%), Positives = 141/305 (46%), Gaps = 40/305 (13%) Query: 8 RADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRV-RVQTGEEGMPLSTIREVAVLR 66 +Y+ +G+G++G+V +D G A+K + + Q ++ S +REV +L+ Sbjct: 29 IFSDRYKGQRVLGKGSFGEVILCKDKITGQE-CAVKVISKRQVKQKTDKESLLREVQLLK 87 Query: 67 HLETFEHPNVVRLFDVCTVSRTDRETKLTLVFE-HVDQDLTTYLDKVPEPGVPTETIKDM 125 L +HPN+++L++ + + LV E + +L + + + Sbjct: 88 QL---DHPNIMKLYEFF-----EDKGYFYLVGEVYTGGELFDEI--ISRKRFSEVDAARI 137 Query: 126 MFQLLRGLDFLHSHRVVHRDLKPQNILVTS---SGQIKLADFGLARIYSFQMALTSVVVT 182 + Q+L G+ ++H +++VHRDLKP+N+L+ S I++ DFGL+ + + + T Sbjct: 138 IRQVLSGITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGT 197 Query: 183 LWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEED 242 +Y APEVL +Y D+WS G I + P F G+++ D L K+ Sbjct: 198 AYYIAPEVLHG-TYDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFELPQ 256 Query: 243 WPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQD 302 W + + E KDL+ K LT+ P+ RISA AL H + Q Sbjct: 257 WKK-----------------------VSESAKDLIRKMLTYVPSMRISARDALDHEWIQT 293 Query: 303 LERCK 307 + + Sbjct: 294 YTKEQ 298 >4E7W-A nrPDB Length = 394 Score = 269 bits (688), Expect = 1e-72, Method: Composition-based stats. Identities = 102/316 (32%), Positives = 163/316 (51%), Gaps = 20/316 (6%) Query: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 Y IG G++G VF+A+ +++ VA+K+V + RE+ ++R ++ Sbjct: 42 YTNCKVIGNGSFGVVFQAKLVESDE--VAIKKVLQDKRFKN------RELQIMRIVK--- 90 Query: 73 HPNVVRLFDVCTVSRTDRET-KLTLVFEHVDQDLTTYLDKVPE--PGVPTETIKDMMFQL 129 HPNVV L + ++ L LV E+V + + + +P IK M+QL Sbjct: 91 HPNVVDLKAFFYSNGDKKDEVFLNLVLEYVPETVYRASRHYAKLKQTMPMLLIKLYMYQL 150 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTS-SGQIKLADFGLARIYSFQMALTSVVVTLWYRAP 188 LR L ++HS + HRD+KPQN+L+ SG +KL DFG A+I S + + +YRAP Sbjct: 151 LRSLAYIHSIGICHRDIKPQNLLLDPPSGVLKLIDFGSAKILIAGEPNVSYICSRYYRAP 210 Query: 189 EVLLQSS-YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPR-D 246 E++ ++ Y T +D+WS GC+ AE+ + +PLF G S +DQL +I+ V+G P E + Sbjct: 211 ELIFGATNYTTNIDIWSTGCVMAELMQGQPLFPGESGIDQLVEIIKVLGTPSREQIKTMN 270 Query: 247 VALPRQAFHSKSAQPIEK-FVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLER 305 F P K F DL+ + L + P+ R++A AL HP+F +L Sbjct: 271 PNYMEHKFPQIRPHPFSKVFRPRTPPDAIDLISRLLEYTPSARLTAIEALCHPFFDELRT 330 Query: 306 CKENLDS--HLPPSQN 319 + + + LPP N Sbjct: 331 GEARMPNGRELPPLFN 346 >4YZB-A nrPDB Length = 491 Score = 267 bits (684), Expect = 3e-72, Method: Composition-based stats. Identities = 76/320 (23%), Positives = 144/320 (45%), Gaps = 41/320 (12%) Query: 9 ADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHL 68 +Y+ +G+G++G+V +D K G+ A+K + + ++ + + L Sbjct: 28 FSDRYKGQRVLGKGSFGEVILCKD-KVTGQEYAVKVISKRQVKQ--KTDKELLLKEVELL 84 Query: 69 ETFEHPNVVRLFDVCTVSRTDRETKLTLVFE-HVDQDLTTYLDKVPEPGVPTETIKDMMF 127 + +HPN+++L++ + + LV E + +L + + ++ Sbjct: 85 KKLDHPNIMKLYEFF-----EDKGYFYLVTEVYTGGELFDEI--ISRKRFSEVDAARIIR 137 Query: 128 QLLRGLDFLHSHRVVHRDLKPQNILVTS---SGQIKLADFGLARIYSFQMALTSVVVTLW 184 Q+L G+ ++H +++VHRDLKP+N+L+ + I++ DFGL+ + + + T + Sbjct: 138 QVLSGITYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAY 197 Query: 185 YRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWP 244 Y APEVL +Y D+WS G I + P F G+++ D L K+ W Sbjct: 198 YIAPEVLHG-TYDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLPQWK 256 Query: 245 RDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLE 304 + + E KDL+ K L + P RISA AL H + + + Sbjct: 257 K-----------------------VSEPAKDLIRKMLAYVPTMRISARDALEHEWLKTTD 293 Query: 305 RCKENLDSHLPPSQNTSELN 324 +++D PS ++ LN Sbjct: 294 AATDSIDV---PSLESTILN 310 >3PG1-A nrPDB Length = 362 Score = 267 bits (682), Expect = 6e-72, Method: Composition-based stats. Identities = 110/314 (35%), Positives = 150/314 (47%), Gaps = 21/314 (6%) Query: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGE---------EGMPLSTIREVA 63 Y I G+YG V D + G VA+KRV + + +RE+ Sbjct: 24 YTVQRFISSGSYGAVCAGVDSE--GIPVAIKRVFNTVSDGRTVNILSDSFLCKRVLREIR 81 Query: 64 VLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIK 123 +L H F HPN++ L D+ KL LV E + DL + + + I+ Sbjct: 82 LLNH---FHHPNILGLRDIFVHFEEPAMHKLYLVTELMRTDLAQVIHD-QRIVISPQHIQ 137 Query: 124 DMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTL 183 M+ +L GL LH VVHRDL P NIL+ + I + DF LAR + T V Sbjct: 138 YFMYHILLGLHVLHEAGVVHRDLHPGNILLADNNDITICDFNLAREDTADANKTHYVTHR 197 Query: 184 WYRAPE-VLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEED 242 WYRAPE V+ + VD+WS GC+ AEMF RK LFRGS+ +QL KI++V+G P ED Sbjct: 198 WYRAPELVMQFKGFTKLVDMWSAGCVMAEMFNRKALFRGSTFYNQLNKIVEVVGTPKIED 257 Query: 243 W-----PRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSH 297 P R + + A+ V D + DL+ K L FNP +RIS AL H Sbjct: 258 VVMFSSPSARDYLRNSLSNVPARAWTAVVPTADPVALDLIAKMLEFNPQRRISTEQALRH 317 Query: 298 PYFQDLERCKENLD 311 PYF+ L + + Sbjct: 318 PYFESLFDPLDLTE 331 >2BDW-A nrPDB Length = 362 Score = 265 bits (678), Expect = 2e-71, Method: Composition-based stats. Identities = 84/309 (27%), Positives = 125/309 (40%), Gaps = 36/309 (11%) Query: 8 RADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRH 67 + Y+ E+G+GA+ V + G F A K + + RE + R Sbjct: 26 KFSDNYDVKEELGKGAFSVVRRCVHKTTGLEFAA-KIINTKKLSARDFQKLEREARICRK 84 Query: 68 LETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMF 127 L+ HPN+VRL D E+ LVF+ V + D V + Sbjct: 85 LQ---HPNIVRLHDSI-----QEESFHYLVFDLVTGG-ELFEDIVAREFYSEADASHCIQ 135 Query: 128 QLLRGLDFLHSHRVVHRDLKPQNILVTSSGQ---IKLADFGLARIYSFQMALTSVVVTLW 184 Q+L + + HS+ +VHR+LKP+N+L+ S + +KLADFGLA + A T Sbjct: 136 QILESIAYCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPG 195 Query: 185 YRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWP 244 Y +PEVL + Y+ PVD+W+ G I + P F +I G D+P Sbjct: 196 YLSPEVLKKDPYSKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQI-----KAGAYDYP 250 Query: 245 RDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLE 304 + K L+ LT NP KRI+A AL P+ + E Sbjct: 251 S------------------PEWDTVTPEAKSLIDSMLTVNPKKRITADQALKVPWICNRE 292 Query: 305 RCKENLDSH 313 R + Sbjct: 293 RVASAIHRQ 301 >2V7O-A nrPDB Length = 336 Score = 265 bits (677), Expect = 2e-71, Method: Composition-based stats. Identities = 85/310 (27%), Positives = 125/310 (40%), Gaps = 37/310 (11%) Query: 8 RADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRH 67 R Y+ E+G+GA+ V + + A K + + RE + R Sbjct: 28 RFTDDYQLFEELGKGAFSVVRRCVKKTPTQEYAA-KIINTKKLSARDHQKLEREARICRL 86 Query: 68 LETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMF 127 L+ HPN+VRL D + E LVF+ V + D V + Sbjct: 87 LK---HPNIVRLHDSIS-----EEGFHYLVFDLVTGG-ELFEDIVAREYYSEADASHCIH 137 Query: 128 QLLRGLDFLHSHRVVHRDLKPQNILVTSSGQ---IKLADFGLA-RIYSFQMALTSVVVTL 183 Q+L ++ +H H +VHRDLKP+N+L+ S + +KLADFGLA + Q A T Sbjct: 138 QILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTP 197 Query: 184 WYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDW 243 Y +PEVL + Y PVD+W+ G I + P F +I G D+ Sbjct: 198 GYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQI-----KAGAYDF 252 Query: 244 PRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDL 303 P + K+L+ + LT NPAKRI+A AL HP+ Sbjct: 253 PS------------------PEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQR 294 Query: 304 ERCKENLDSH 313 + Sbjct: 295 STVASMMHRQ 304 >5FG8-A nrPDB Length = 285 Score = 264 bits (675), Expect = 4e-71, Method: Composition-based stats. Identities = 86/305 (28%), Positives = 121/305 (39%), Gaps = 37/305 (12%) Query: 8 RADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRH 67 R Y+ E+G+GA+ V + G F A K + + RE + R Sbjct: 11 RFSDNYDIKEELGKGAFSIVKRCVQKSTGFEFAA-KIINTKKLTARDFQKLEREARICRK 69 Query: 68 LETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMF 127 L HPN+VRL D E LVF+ V + D V + Sbjct: 70 L---HHPNIVRLHDSI-----QEENYHYLVFDLVTGG-ELFEDIVAREFYSEADASHCIQ 120 Query: 128 QLLRGLDFLHSHRVVHRDLKPQNILVTSSGQ---IKLADFGLA-RIYSFQMALTSVVVTL 183 Q+L ++ H + VVHRDLKP+N+L+ S + +KLADFGLA + A T Sbjct: 121 QILESVNHCHQNGVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTP 180 Query: 184 WYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDW 243 Y +PEVL + Y VD+W+ G I + P F +I G D+ Sbjct: 181 GYLSPEVLKKEPYGKSVDIWACGVILYILLVGYPPFWDEDQHRLYSQI-----KAGAYDY 235 Query: 244 PRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDL 303 P + K+L+ + LT NP KRI+A AL HP+ Sbjct: 236 PS------------------PEWDTVTPEAKNLINQMLTVNPNKRITAAEALKHPWICQR 277 Query: 304 ERCKE 308 ER Sbjct: 278 ERVAS 282 >2VN9-A nrPDB Length = 301 Score = 264 bits (674), Expect = 4e-71, Method: Composition-based stats. Identities = 86/308 (27%), Positives = 126/308 (40%), Gaps = 37/308 (12%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLE 69 +Y+ E+G+GA+ V + + G + A K + + RE + R L+ Sbjct: 3 TDEYQLFEELGKGAFSVVRRCMKIPTGQEYAA-KIINTKKLSARDHQKLEREARICRLLK 61 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQL 129 HPN+VRL D + E LVF+ V + D V + Q+ Sbjct: 62 ---HPNIVRLHDSIS-----EEGFHYLVFDLVTGG-ELFEDIVAREYYSEADASHCIQQI 112 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQ---IKLADFGLA-RIYSFQMALTSVVVTLWY 185 L ++ H + +VHRDLKP+N+L+ S + +KLADFGLA + Q A T Y Sbjct: 113 LESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGY 172 Query: 186 RAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPR 245 +PEVL + Y PVD+W+ G I + P F +I G D+P Sbjct: 173 LSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQI-----KAGAYDFPS 227 Query: 246 DVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLER 305 + KDL+ K LT NPAKRI+A AL HP+ Sbjct: 228 ------------------PEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWICQRST 269 Query: 306 CKENLDSH 313 + Sbjct: 270 VASMMHRQ 277 >5AIR-A nrPDB Length = 430 Score = 264 bits (674), Expect = 5e-71, Method: Composition-based stats. Identities = 97/336 (28%), Positives = 158/336 (47%), Gaps = 22/336 (6%) Query: 2 EKDGLCRADQ-QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR 60 G R + Y IG G++G V++A+ + G VA+K+V + R Sbjct: 54 PGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLC-DSGELVAIKKVLQDKRFKN------R 106 Query: 61 EVAVLRHLETFEHPNVVRL-FDVCTVSRTDRETKLTLVFEHVDQDLTTYLDK--VPEPGV 117 E+ ++R L +H N+VRL + + E L LV ++V + + + + Sbjct: 107 ELQIMRKL---DHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTL 163 Query: 118 PTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQI-KLADFGLARIYSFQMAL 176 P +K M+QL R L ++HS + HRD+KPQN+L+ + KL DFG A+ Sbjct: 164 PVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPN 223 Query: 177 TSVVVTLWYRAPEVLLQSS-YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVI 235 S + + +YRAPE++ ++ Y + +D+WS GC+ AE+ +P+F G S VDQL +I+ V+ Sbjct: 224 VSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVL 283 Query: 236 GLPGEEDWPR-DVALPRQAFHSKSAQPIEK-FVTDIDELGKDLLLKCLTFNPAKRISAYS 293 G P E + F A P K F L + L + P R++ Sbjct: 284 GTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLE 343 Query: 294 ALSHPYFQDLERCKENLDS--HLPPSQN--TSELNT 325 A +H +F +L L + P N T EL++ Sbjct: 344 ACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSS 379 >3RP9-A nrPDB Length = 458 Score = 263 bits (672), Expect = 9e-71, Method: Composition-based stats. Identities = 107/364 (29%), Positives = 159/364 (43%), Gaps = 70/364 (19%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 +YE IG G+YG V +A D K R VA+K++ + +RE+A+L L Sbjct: 53 DRYEIRHLIGTGSYGHVCEAYD-KLEKRVVAIKKILRVFEDLIDCKRILREIAILNRL-- 109 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130 H +VV++ D+ ++ +L +V E D D + IK +++ LL Sbjct: 110 -NHDHVVKVLDIVIPKDVEKFDELYVVLEIADSDFKKLFR--TPVYLTELHIKTLLYNLL 166 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQM---------------- 174 G+ ++HS ++HRDLKP N LV +K+ DFGLAR + Sbjct: 167 VGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFGLARTVDYPENGNSQLPISPREDDMN 226 Query: 175 ------------ALTSVVVTLWYRAPE-VLLQSSYATPVDLWSVGCIFAEMFR------- 214 LT VVT WYRAPE +LLQ +Y +D+WS+GCIFAE+ Sbjct: 227 LVTFPHTKNLKRQLTGHVVTRWYRAPELILLQENYTEAIDVWSIGCIFAELLNMIKENVA 286 Query: 215 ----RKPLFRGSS--------------------DVDQLGKILDVIGLPGEEDW----PRD 246 R PLF GSS + DQL I +++G P EED D Sbjct: 287 YHADRGPLFPGSSCFPLSPDQKAGNDFKFHTRGNRDQLNVIFNILGTPSEEDIEALEKED 346 Query: 247 VALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERC 306 + F + + + LL + L FNP KRI+ L+HP+F+++ Sbjct: 347 AKRYIRIFPKREGTDLAERFPASSADAIHLLKRMLVFNPNKRITINECLAHPFFKEVRIA 406 Query: 307 KENL 310 + Sbjct: 407 EVET 410 >3KK8-A nrPDB Length = 284 Score = 262 bits (669), Expect = 2e-70, Method: Composition-based stats. Identities = 84/309 (27%), Positives = 125/309 (40%), Gaps = 36/309 (11%) Query: 8 RADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRH 67 + Y+ E+G+GA+ V + G F A K + + RE + R Sbjct: 3 KFSDNYDVKEELGKGAFSVVRRCVHKTTGLEFAA-KIINTKKLSARDFQKLEREARICRK 61 Query: 68 LETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMF 127 L+ HPN+VRL D E+ LVF+ V + D V + Sbjct: 62 LQ---HPNIVRLHDSI-----QEESFHYLVFDLVTGG-ELFEDIVAREFYSEADASHCIQ 112 Query: 128 QLLRGLDFLHSHRVVHRDLKPQNILVTSSGQ---IKLADFGLARIYSFQMALTSVVVTLW 184 Q+L + + HS+ +VHR+LKP+N+L+ S + +KLADFGLA + A T Sbjct: 113 QILESIAYCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPG 172 Query: 185 YRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWP 244 Y +PEVL + Y+ PVD+W+ G I + P F +I G D+P Sbjct: 173 YLSPEVLKKDPYSKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQI-----KAGAYDYP 227 Query: 245 RDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLE 304 + K L+ LT NP KRI+A AL P+ + E Sbjct: 228 S------------------PEWDTVTPEAKSLIDSMLTVNPKKRITADQALKVPWICNRE 269 Query: 305 RCKENLDSH 313 R + Sbjct: 270 RVASAIHRQ 278 >3SOA-A nrPDB Length = 444 Score = 261 bits (667), Expect = 4e-70, Method: Composition-based stats. Identities = 85/310 (27%), Positives = 126/310 (40%), Gaps = 37/310 (11%) Query: 8 RADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRH 67 R ++Y+ E+G+GA+ V + + G + A+ + + RE + R Sbjct: 8 RFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAM-IINTKKLSARDHQKLEREARICRL 66 Query: 68 LETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMF 127 L+ HPN+VRL D + E L+F+ V + D V + Sbjct: 67 LK---HPNIVRLHDSIS-----EEGHHYLIFDLVTGG-ELFEDIVAREYYSEADASHCIQ 117 Query: 128 QLLRGLDFLHSHRVVHRDLKPQNILVTSSGQ---IKLADFGLA-RIYSFQMALTSVVVTL 183 Q+L + H VVHR+LKP+N+L+ S + +KLADFGLA + Q A T Sbjct: 118 QILEAVLHCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTP 177 Query: 184 WYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDW 243 Y +PEVL + Y PVDLW+ G I + P F +I G D+ Sbjct: 178 GYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQI-----KAGAYDF 232 Query: 244 PRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDL 303 P + KDL+ K LT NP+KRI+A AL HP+ Sbjct: 233 PS------------------PEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHR 274 Query: 304 ERCKENLDSH 313 + Sbjct: 275 STVASCMHRQ 284 >3COM-A nrPDB Length = 314 Score = 261 bits (666), Expect = 4e-70, Method: Composition-based stats. Identities = 78/304 (25%), Positives = 147/304 (48%), Gaps = 39/304 (12%) Query: 1 MEKDGLCR-ADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTI 59 +++D L + ++ ++ + ++GEG+YG V+KA K G+ VA+K+V V E I Sbjct: 18 LDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIH-KETGQIVAIKQVPV----ESDLQEII 72 Query: 60 REVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPT 119 +E+++++ ++ P+VV+ + + T L +V E+ + + ++ + Sbjct: 73 KEISIMQQCDS---PHVVKYYGSYF-----KNTDLWIVMEYCGAGSVSDIIRLRNKTLTE 124 Query: 120 ETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQM-ALTS 178 + I ++ L+GL++LH R +HRD+K NIL+ + G KLADFG+A + M + Sbjct: 125 DEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNT 184 Query: 179 VVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLP 238 V+ T ++ APEV+ + Y D+WS+G EM KP + +D+ + I + P Sbjct: 185 VIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPY---ADIHPMRAIFMIPTNP 241 Query: 239 GEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHP 298 P + + D + +CL +P +R +A L HP Sbjct: 242 ---------------------PPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHP 280 Query: 299 YFQD 302 + + Sbjct: 281 FVRS 284 >5U6Y-A nrPDB Length = 461 Score = 261 bits (666), Expect = 4e-70, Method: Composition-based stats. Identities = 86/305 (28%), Positives = 123/305 (40%), Gaps = 37/305 (12%) Query: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 Y+ E+G+GA+ V + + G + A K + + RE + R L+ Sbjct: 2 YQLFEELGKGAFSVVRRCVKVLAGQEYAA-KIINTKKLSARDHQKLEREARICRLLK--- 57 Query: 73 HPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRG 132 HPN+VRL D + E L+F+ V + D V + Q+L Sbjct: 58 HPNIVRLHDSIS-----EEGHHYLIFDLVTGG-ELFEDIVAREYYSEADASHCIQQILEA 111 Query: 133 LDFLHSHRVVHRDLKPQNILVTSSGQ---IKLADFGLA-RIYSFQMALTSVVVTLWYRAP 188 + H VVHRDLKP+N+L+ S + +KLADFGLA + Q A T Y +P Sbjct: 112 VLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSP 171 Query: 189 EVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA 248 EVL + Y PVDLW+ G I + P F +I G D+P Sbjct: 172 EVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQI-----KAGAYDFPS--- 223 Query: 249 LPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKE 308 + KDL+ K LT NP+KRI+A AL HP+ Sbjct: 224 ---------------PEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVAS 268 Query: 309 NLDSH 313 + Sbjct: 269 CMHRQ 273 >4O2Z-A nrPDB Length = 377 Score = 260 bits (665), Expect = 6e-70, Method: Composition-based stats. Identities = 101/311 (32%), Positives = 156/311 (50%), Gaps = 12/311 (3%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 +Y + +G GAYG D + G V++K+ R + +RE+ ++R Sbjct: 45 SKYTLLKILGMGAYGIACSCLDG-DTGEKVSIKKCRDVFRDVEDGKRVLREIDMMR---F 100 Query: 71 FEHPNVVRLFDVC--TVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQ 128 F H N++ + ++ + +V +D D+ L + ++ ++Q Sbjct: 101 FHHENLLNVVNILPPLKREYHSFEDVYVVTPLMDVDMNVVLRS--RQVLEESHMQYFVYQ 158 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYS-FQMALTSVVVTLWYRA 187 +LRGL +LHS V HRDLKP N++ S ++K+ DFGL+R LT V+T WYR Sbjct: 159 ILRGLKYLHSANVAHRDLKPANLVTNISCELKIIDFGLSRSVDVPYSELTDYVITRWYRP 218 Query: 188 PEVLLQSS-YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRD 246 PE+LL+++ Y+T VD+WSVGCIFAEM+ RKP+F G + +DQL I IG P Sbjct: 219 PELLLENTNYSTAVDIWSVGCIFAEMYNRKPVFPGRNTMDQLRMIAQHIGKPPASIVEHR 278 Query: 247 VALPRQAFHSKSAQPIEKFVTDI--DELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLE 304 AL + + I K V + + G D L K T +P+KR +A L+HPY L Sbjct: 279 EALEKLNELPDGSLNIPKLVPGLAGNTEGIDFLSKMWTLDPSKRPTAADMLAHPYLAHLH 338 Query: 305 RCKENLDSHLP 315 ++ P Sbjct: 339 DEEDEPTCPCP 349 >3N9X-A nrPDB Length = 432 Score = 260 bits (664), Expect = 8e-70, Method: Composition-based stats. Identities = 112/353 (31%), Positives = 164/353 (46%), Gaps = 62/353 (17%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 Y IG G+YG V+ A D KN + VA+K+V + +RE+ +L L++ Sbjct: 26 DNYIIKHLIGRGSYGYVYLAYD-KNTEKNVAIKKVNRMFEDLIDCKRILREITILNRLKS 84 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130 ++RL+D+ + +L +V E D DL + E IK +++ LL Sbjct: 85 ---DYIIRLYDLIIPDDLLKFDELYIVLEIADSDLKKLFK--TPIFLTEEHIKTILYNLL 139 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQ----------------- 173 G +F+H ++HRDLKP N L+ +K+ DFGLAR + + Sbjct: 140 LGENFIHESGIIHRDLKPANCLLNQDCSVKVCDFGLARTINSEKDTNIVNDLEENEEPGP 199 Query: 174 ------MALTSVVVTLWYRAPE-VLLQSSYATPVDLWSVGCIFAEMF-----------RR 215 LTS VVT WYRAPE +LLQ +Y +D+WS GCIFAE+ R Sbjct: 200 HNKNLKKQLTSHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAELLNMLQSHINDPTNR 259 Query: 216 KPLFRGS-----------------SDVDQLGKILDVIGLPGEEDWPR----DVALPRQAF 254 PLF GS S+ DQL I ++IG P E+D +V + F Sbjct: 260 FPLFPGSSCFPLSPDRNSKKVHEKSNRDQLNIIFNIIGTPTEDDLKNINKPEVIKYIKLF 319 Query: 255 HSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCK 307 + +++ I + G +LL L FNP KRI+ AL HPY +D+ + K Sbjct: 320 PHRKPINLKQKYPSISDDGINLLESMLKFNPNKRITIDQALDHPYLKDVRKKK 372 >4FG9-A nrPDB Length = 320 Score = 259 bits (663), Expect = 1e-69, Method: Composition-based stats. Identities = 81/304 (26%), Positives = 132/304 (43%), Gaps = 39/304 (12%) Query: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 Y+ +G GA+ +V A D + + VA+K + + EG S E+AVL ++ Sbjct: 20 YDFRDVLGTGAFSEVILAEDKRT-QKLVAIKCIAKEAL-EGKEGSMENEIAVLHKIK--- 74 Query: 73 HPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGV-PTETIKDMMFQLLR 131 HPN+V L D+ + L L+ + V D++ E G ++FQ+L Sbjct: 75 HPNIVALDDIY-----ESGGHLYLIMQLVSGG--ELFDRIVEKGFYTERDASRLIFQVLD 127 Query: 132 GLDFLHSHRVVHRDLKPQNIL---VTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAP 188 + +LH +VHRDLKP+N+L + +I ++DFGL+++ L++ T Y AP Sbjct: 128 AVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAP 187 Query: 189 EVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA 248 EVL Q Y+ VD WS+G I + P F +D +IL Sbjct: 188 EVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKA-------------- 233 Query: 249 LPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKE 308 + + DI + KD + + +P KR + AL HP+ + Sbjct: 234 ---------EYEFDSPYWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIAGDTALDK 284 Query: 309 NLDS 312 N+ Sbjct: 285 NIHQ 288 >2VZ6-A nrPDB Length = 313 Score = 259 bits (661), Expect = 1e-69, Method: Composition-based stats. Identities = 86/309 (27%), Positives = 123/309 (39%), Gaps = 37/309 (11%) Query: 9 ADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHL 68 Y+ E+G+GA+ V + + G + A K + + RE + R L Sbjct: 20 FQSMYQLFEELGKGAFSVVRRCVKVLAGQEYAA-KIINTKKLSARDHQKLEREARICRLL 78 Query: 69 ETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQ 128 + HPN+VRL D + E L+F+ V + D V + Q Sbjct: 79 K---HPNIVRLHDSIS-----EEGHHYLIFDLVTGG-ELFEDIVAREYYSEADASHCIQQ 129 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQ---IKLADFGLA-RIYSFQMALTSVVVTLW 184 +L + H VVHRDLKP+N+L+ S + +KLADFGLA + Q A T Sbjct: 130 ILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPG 189 Query: 185 YRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWP 244 Y +PEVL + Y PVDLW+ G I + P F +I G D+P Sbjct: 190 YLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQI-----KAGAYDFP 244 Query: 245 RDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLE 304 + KDL+ K LT NP+KRI+A AL HP+ Sbjct: 245 S------------------PEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHRS 286 Query: 305 RCKENLDSH 313 + Sbjct: 287 TVASCMHRQ 295 >5Y86-A nrPDB Length = 588 Score = 258 bits (660), Expect = 2e-69, Method: Composition-based stats. Identities = 92/336 (27%), Positives = 158/336 (47%), Gaps = 43/336 (12%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETF 71 +YE + IG+G++G+V + D K ++VALK VR + IR + L+ + Sbjct: 208 RYEVLKIIGKGSFGQVARVYDHKL-RQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKT 266 Query: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLR 131 NV+ + + T + + FE + DL + K G + ++ +L+ Sbjct: 267 GSMNVIHMLESFTF-----RNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQ 321 Query: 132 GLDFLHSHRVVHRDLKPQNILVTSSGQ--IKLADFGLARIYSFQMALTSVVVTLWYRAPE 189 LD LH ++++H DLKP+NIL+ G+ K+ DFG + L + + + +YRAPE Sbjct: 322 SLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF--EYQKLYTYIQSRFYRAPE 379 Query: 190 VLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEED------- 242 ++L S Y+TP+D+WS GCI AE+ +PLF G + DQL +++++G+P + Sbjct: 380 IILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRA 439 Query: 243 --------WPRDVALP------------RQAFHSKSAQPIEKFVTDI-----DELGKDLL 277 PR ++ R K P K D L + L Sbjct: 440 KYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFL 499 Query: 278 LKCLTFNPAKRISAYSALSHPYF-QDLERCKENLDS 312 +CL ++P+ R++ AL HP+ + + R +D Sbjct: 500 KRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDK 535 >4RGJ-A nrPDB Length = 520 Score = 258 bits (659), Expect = 3e-69, Method: Composition-based stats. Identities = 85/316 (26%), Positives = 151/316 (47%), Gaps = 42/316 (13%) Query: 9 ADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRV-RVQTGEEGMPLSTIREVAVLRH 67 ++QY+ + +G+G++G+V +RD K+ G A+K + + + S +REV +L+ Sbjct: 58 FNEQYKGIKILGKGSFGEVILSRD-KHTGHEYAIKVISKKHVKRKTDKESLLREVELLKM 116 Query: 68 LETFEHPNVVRLFDVCTVSRTDRETKLTLVFE-HVDQDLTTYLDKVPEPGVPTETIKDMM 126 L +H N+++L++ + LV + + +L + + ++ Sbjct: 117 L---DHINIMKLYEFF-----EDNNYYYLVSDVYTGGELFDEI--ISRKRFYEIDAARII 166 Query: 127 FQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQ----IKLADFGLARIYSFQMALTSVVVT 182 Q+L G+ ++H + VVHRDLKP+NIL+ + + IK+ DFGL+ + + + + T Sbjct: 167 KQILSGITYMHKNNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHFEYSKKMKDKIGT 226 Query: 183 LWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEED 242 +Y AP+VL +Y D+WS G I + P F GS++ D L K+ E Sbjct: 227 AYYIAPDVLHG-TYDEKCDIWSCGVILYILLSGCPPFNGSNEYDILKKV---------EA 276 Query: 243 WPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQD 302 LP+ I + KDL+ K L + A RISA AL H + + Sbjct: 277 GKYTFDLPQ--------------FKKISDKAKDLIKKMLMYTSAVRISARDALEHEWIK- 321 Query: 303 LERCKENLDSHLPPSQ 318 + K+NL+ +P + Sbjct: 322 MMTSKDNLNIDIPSLE 337 >3NIE-A nrPDB Length = 429 Score = 257 bits (658), Expect = 4e-69, Method: Composition-based stats. Identities = 117/364 (32%), Positives = 169/364 (46%), Gaps = 67/364 (18%) Query: 8 RADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRH 67 + YE IG G+YG V+ A D KN + VA+K+V + +RE+ +L Sbjct: 25 KVPDNYEIKHLIGRGSYGYVYLAYD-KNANKNVAIKKVNRMFEDLIDCKRILREITILNR 83 Query: 68 LETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMF 127 L++ ++RL D+ + +L +V E D DL + + +K +++ Sbjct: 84 LKS---DYIIRLHDLIIPEDLLKFDELYIVLEIADSDLKKLFK--TPIFLTEQHVKTILY 138 Query: 128 QLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQ-------------- 173 LL G F+H ++HRDLKP N L+ +K+ DFGLAR + Sbjct: 139 NLLLGEKFIHESGIIHRDLKPANCLLNQDCSVKICDFGLARTINSDKDIHIVNDLEEKEE 198 Query: 174 ------------MALTSVVVTLWYRAPE-VLLQSSYATPVDLWSVGCIFAEMF------- 213 LTS VVT WYRAPE +LLQ +Y +D+WS GCIFAE+ Sbjct: 199 NEEPGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDIWSTGCIFAELLNMMKSHI 258 Query: 214 ----RRKPLFRGS-----------------SDVDQLGKILDVIGLPGEEDW----PRDVA 248 R PLF GS S+ DQL I +VIG P EED ++V Sbjct: 259 NNPTNRFPLFPGSSCFPLSPDHNSKKVHEKSNRDQLNIIFNVIGTPPEEDLKCITKQEVI 318 Query: 249 LPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKE 308 + F ++ + K + I + G DLL L FN KRI+ ALSHPY +D+ + E Sbjct: 319 KYIKLFPTRDGIDLSKKYSSISKEGIDLLESMLRFNAQKRITIDKALSHPYLKDVRK--E 376 Query: 309 NLDS 312 NL++ Sbjct: 377 NLEN 380 >5IG1-A nrPDB Length = 344 Score = 257 bits (657), Expect = 5e-69, Method: Composition-based stats. Identities = 66/293 (22%), Positives = 115/293 (39%), Gaps = 36/293 (12%) Query: 17 AEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNV 76 + IG+GA+ V + + + G A+K + +++ RE+ + + +H ++ Sbjct: 23 SVIGKGAFSTVHRCVNKRT-GEVCAVKVIALKSLRSSEINKIKREIGI---CSSLQHEHI 78 Query: 77 VRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFL 136 V + E+ LVFE+V + + V + M Q+L L Sbjct: 79 VSMRRAF-----RDESHFYLVFEYVSGG-ELFDEIVTRKFYNEKDASACMHQILSALQHC 132 Query: 137 HSHRVVHRDLKPQNILV---TSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQ 193 HS ++HRDLKP+N+L+ + +K+ DFGLA I T Y +PEV+ + Sbjct: 133 HSKNIIHRDLKPENLLLASKDPNAPVKITDFGLAVIMEQGPTYFGFAGTPGYLSPEVIRR 192 Query: 194 SSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQA 253 Y T VD+W+ G I + P F +I + + D+P Sbjct: 193 VPYDTAVDVWACGVILYILLVGYPPFWEEDHQKLYAQIKNC-----QYDFPS-------- 239 Query: 254 FHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERC 306 + K+L+ L NP +R + L HP+ + Sbjct: 240 ----------PEWDSVTTAAKELIKAMLEPNPKRRPTVQELLQHPWIARRDVP 282 >3Q5I-A nrPDB Length = 504 Score = 257 bits (657), Expect = 5e-69, Method: Composition-based stats. Identities = 83/324 (25%), Positives = 141/324 (43%), Gaps = 44/324 (13%) Query: 2 EKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIRE 61 +K+G + + Y V ++G GAYG+V ++ KNG A+K ++ ++G + Sbjct: 29 KKEG--KIGESYFKVRKLGSGAYGEVLLCKE-KNGHSEKAIKVIKKSQFDKGRYSDDNKN 85 Query: 62 VA--------VLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVP 113 + + L++ +HPN+++LFDV + + LV E + + + Sbjct: 86 IEKFHEEIYNEISLLKSLDHPNIIKLFDVF-----EDKKYFYLVTEFYEGG-ELFEQIIN 139 Query: 114 EPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSG---QIKLADFGLARIY 170 ++M Q+L G+ +LH H +VHRD+KP+NIL+ + IK+ DFGL+ + Sbjct: 140 RHKFDECDAANIMKQILSGICYLHKHNIVHRDIKPENILLENKNSLLNIKIVDFGLSSFF 199 Query: 171 SFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGK 230 S L + T +Y APEVL Y D+WS G I + P F G +D D + K Sbjct: 200 SKDYKLRDRLGTAYYIAPEVLK-KKYNEKCDVWSCGVIMYILLCGYPPFGGQNDQDIIKK 258 Query: 231 ILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRIS 290 + DW +I + K+L+ LT++ KR + Sbjct: 259 VEKGKYYFDFNDWK-----------------------NISDEAKELIKLMLTYDYNKRCT 295 Query: 291 AYSALSHPYFQDLERCKENLDSHL 314 A AL+ + + D Sbjct: 296 AEEALNSRWIKKYANNINKSDQKT 319 >2JC6-A nrPDB Length = 334 Score = 257 bits (657), Expect = 5e-69, Method: Composition-based stats. Identities = 77/292 (26%), Positives = 127/292 (43%), Gaps = 39/292 (13%) Query: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 +E +G GA+ +V A + K G+ A+K + + +G S E+AVLR ++ Sbjct: 24 FEFKETLGTGAFSEVVLAEE-KATGKLFAVKCIPKKAL-KGKESSIENEIAVLRKIK--- 78 Query: 73 HPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGV-PTETIKDMMFQLLR 131 H N+V L D+ + L LV + V D++ E G + ++ Q+L Sbjct: 79 HENIVALEDIY-----ESPNHLYLVMQLVSGG--ELFDRIVEKGFYTEKDASTLIRQVLD 131 Query: 132 GLDFLHSHRVVHRDLKPQNILV---TSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAP 188 + +LH +VHRDLKP+N+L +I ++DFGL+++ +++ T Y AP Sbjct: 132 AVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAP 191 Query: 189 EVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA 248 EVL Q Y+ VD WS+G I + P F +D +IL Sbjct: 192 EVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKA-------------- 237 Query: 249 LPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 + + DI + KD + + +P KR + A HP+ Sbjct: 238 ---------EYEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWI 280 >3BHH-A nrPDB Length = 295 Score = 255 bits (653), Expect = 1e-68, Method: Composition-based stats. Identities = 85/308 (27%), Positives = 125/308 (40%), Gaps = 37/308 (12%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLE 69 +Y+ +IG+GA+ V + L G + A K + + RE + R L+ Sbjct: 3 TDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAA-KIINTKKLSARDHQKLEREARICRLLK 61 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQL 129 H N+VRL D + E LVF+ V + D V + Q+ Sbjct: 62 ---HSNIVRLHDSIS-----EEGFHYLVFDLVTGG-ELFEDIVAREYYSEADASHCIQQI 112 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQ---IKLADFGLA-RIYSFQMALTSVVVTLWY 185 L + H VVHRDLKP+N+L+ S + +KLADFGLA + Q A T Y Sbjct: 113 LEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGY 172 Query: 186 RAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPR 245 +PEVL + +Y PVD+W+ G I + P F +I G D+P Sbjct: 173 LSPEVLRKEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQI-----KAGAYDFPS 227 Query: 246 DVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLER 305 + K+L+ + LT NPAKRI+A+ AL HP+ Sbjct: 228 ------------------PEWDTVTPEAKNLINQMLTINPAKRITAHEALKHPWVCQRST 269 Query: 306 CKENLDSH 313 + Sbjct: 270 VASMMHRQ 277 >4LG4-A nrPDB Length = 299 Score = 255 bits (653), Expect = 2e-68, Method: Composition-based stats. Identities = 78/296 (26%), Positives = 142/296 (47%), Gaps = 38/296 (12%) Query: 8 RADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRH 67 + ++ ++ + ++GEG+YG VFKA K G+ VA+K+V V E I+E+++++ Sbjct: 8 QPEEVFDVLEKLGEGSYGSVFKAIH-KESGQVVAIKQVPV----ESDLQEIIKEISIMQQ 62 Query: 68 LETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMF 127 ++ P VV+ + + T L +V E+ + + ++ + + I ++ Sbjct: 63 CDS---PYVVKYYGSYF-----KNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILK 114 Query: 128 QLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQM-ALTSVVVTLWYR 186 L+GL++LH R +HR++K NIL+ + G KLADFG+A + M +V+ T ++ Sbjct: 115 STLKGLEYLHFMRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWM 174 Query: 187 APEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRD 246 APEV+ + Y D+WS+G EM KP + +D+ + I + P Sbjct: 175 APEVIQEIGYNCVADIWSLGITSIEMAEGKPPY---ADIHPMRAIFMIPTNP-------- 223 Query: 247 VALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQD 302 P + + D + KCL NP +R +A L HP+ ++ Sbjct: 224 -------------PPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKN 266 >5YKS-A nrPDB Length = 377 Score = 255 bits (651), Expect = 3e-68, Method: Composition-based stats. Identities = 82/300 (27%), Positives = 135/300 (45%), Gaps = 40/300 (13%) Query: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 Y+ +G G + V AR + G + VA+K + + +EV ++ + Sbjct: 37 YDLDKTLGRGHFAVVKLARHVFTGEK-VAVKVIDKTKLDTLATGHLFQEVRCMK---LVQ 92 Query: 73 HPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQLLR 131 HPN+VRL++V D +TKL L+ E D D+ Y+ K E G+ + K Q++ Sbjct: 93 HPNIVRLYEVI-----DTQTKLYLILELGDGGDMFDYIMK-HEEGLNEDLAKKYFAQIVH 146 Query: 132 GLDFLHSHRVVHRDLKPQN-ILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEV 190 + + H VVHRDLKP+N + G +KL DFG + + LT+ +L Y APE+ Sbjct: 147 AISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEI 206 Query: 191 LLQSSYATP-VDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVAL 249 LL Y P VD+WS+G I + +P F+ ++D + L I+D Sbjct: 207 LLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYT------------ 254 Query: 250 PRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKEN 309 + + + KDL+ + L +P +R S +HP+ Q ++ Sbjct: 255 ---------------VPSHVSKECKDLITRMLQRDPKRRASLEEIENHPWLQGVDPSPAT 299 >3ZDU-A nrPDB Length = 325 Score = 254 bits (650), Expect = 3e-68, Method: Composition-based stats. Identities = 104/296 (35%), Positives = 159/296 (53%), Gaps = 17/296 (5%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 + YE + ++GEG+YG V K + KN G+ VA+K + E+ + +RE+ L+ Sbjct: 3 EMYETLGKVGEGSYGTVMKCKH-KNTGQIVAIKIF-YERPEQSVNKIAMREIKFLKQ--- 57 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130 F H N+V L +V ++ K+ LVFE +D + L G+ ++ ++ +FQ+L Sbjct: 58 FHHENLVNLIEVF-----RQKKKIHLVFEFIDHTVLDELQHYCH-GLESKRLRKYLFQIL 111 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY-SFQMALTSVVVTLWYRAPE 189 R +D+LHS+ ++HRD+KP+NILV+ SG KL DFG AR + V T WYRAPE Sbjct: 112 RAIDYLHSNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYDDEVATRWYRAPE 171 Query: 190 -VLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIG--LPGEEDWPRD 246 VL +SY PVD+W++GC+ EM P SSD+D L KI+ +G P ++ Sbjct: 172 LVLKDTSYGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSK 231 Query: 247 VALPRQAFHSKSAQP--IEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 + + P K ++ L D++ CL +PA RIS+ L H YF Sbjct: 232 SPIFAGVVLPQVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYF 287 >3E3P-A nrPDB Length = 360 Score = 253 bits (647), Expect = 6e-68, Method: Composition-based stats. Identities = 99/315 (31%), Positives = 149/315 (47%), Gaps = 20/315 (6%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 +++ G+G +G V ++ K+ G VA+K+V P RE+ +++ L Sbjct: 23 DRFQVERMAGQGTFGTVQLGKE-KSTGMSVAIKKVIQD------PRFRNRELQIMQDLAV 75 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTL--VFEHVDQDLTTYLDKVPEPGV--PTETIKDMM 126 HPN+V+L + L V E+V L V P IK + Sbjct: 76 LHHPNIVQLQSYFYTLGERDRRDIYLNVVMEYVPDTLHRCCRNYYRRQVAPPPILIKVFL 135 Query: 127 FQLLRGLDFLH--SHRVVHRDLKPQNILVTS-SGQIKLADFGLARIYSFQMALTSVVVTL 183 FQL+R + LH S V HRD+KP N+LV G +KL DFG A+ S + + + Sbjct: 136 FQLIRSIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKLSPSEPNVAYICSR 195 Query: 184 WYRAPEVLLQ-SSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEED 242 +YRAPE++ Y T VD+WSVGCIFAEM +P+FRG + QL +I+ V+G P E Sbjct: 196 YYRAPELIFGNQHYTTAVDIWSVGCIFAEMMLGEPIFRGDNSAGQLHEIVRVLGCPSREV 255 Query: 243 WPR-DVALPRQAFHSKSAQPIEKFVTDID----ELGKDLLLKCLTFNPAKRISAYSALSH 297 + + + ++ P +D + DLL L + P +R+ Y AL H Sbjct: 256 LRKLNPSHTDVDLYNSKGIPWSNVFSDHSLKDAKEAYDLLSALLQYLPEERMKPYEALCH 315 Query: 298 PYFQDLERCKENLDS 312 PYF +L L + Sbjct: 316 PYFDELHDPATKLPN 330 >6AO5-A nrPDB Length = 362 Score = 253 bits (647), Expect = 7e-68, Method: Composition-based stats. Identities = 78/296 (26%), Positives = 142/296 (47%), Gaps = 38/296 (12%) Query: 8 RADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRH 67 + ++ ++ + ++GEG+YG VFKA K G+ VA+K+V V E I+E+++++ Sbjct: 7 QPEEVFDVLEKLGEGSYGSVFKAIH-KESGQVVAIKQVPV----ESDLQEIIKEISIMQQ 61 Query: 68 LETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMF 127 ++ P VV+ + + T L +V E+ + + ++ + + I ++ Sbjct: 62 CDS---PYVVKYYGSYF-----KNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILK 113 Query: 128 QLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQM-ALTSVVVTLWYR 186 L+GL++LH R +HR++K NIL+ + G KLADFG+A + M +V+ T ++ Sbjct: 114 STLKGLEYLHFMRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWM 173 Query: 187 APEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRD 246 APEV+ + Y D+WS+G EM KP + +D+ + I + P Sbjct: 174 APEVIQEIGYNCVADIWSLGITSIEMAEGKPPY---ADIHPMRAIFMIPTNP-------- 222 Query: 247 VALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQD 302 P + + D + KCL NP +R +A L HP+ ++ Sbjct: 223 -------------PPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKN 265 >3MN3-A nrPDB Length = 271 Score = 253 bits (646), Expect = 8e-68, Method: Composition-based stats. Identities = 77/305 (25%), Positives = 133/305 (43%), Gaps = 41/305 (13%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQT-GEEGMPLSTIREVAVLRHLET 70 Y+ V +GEG++GKV A G+ VALK + + + M RE++ LR L Sbjct: 5 NYQIVKTLGEGSFGKVKLAYHT-TTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLR- 62 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130 HP++++L+DV + ++ +V E+ +L Y+ V + + + Q++ Sbjct: 63 --HPHIIKLYDVIK-----SKDEIIMVIEYAGNELFDYI--VQRDKMSEQEARRFFQQII 113 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEV 190 +++ H H++VHRDLKP+N+L+ +K+ADFGL+ I + L + + Y APEV Sbjct: 114 SAVEYCHRHKIVHRDLKPENLLLDEHLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEV 173 Query: 191 LLQSSY-ATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVAL 249 + Y VD+WS G I M R+ F S I + + Sbjct: 174 ISGKLYAGPEVDVWSCGVILYVMLCRRLPFDDESIPVLFKNISNGVYT------------ 221 Query: 250 PRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKEN 309 + L+ + L NP RIS + + +F+ ++ + Sbjct: 222 ---------------LPKFLSPGAAGLIKRMLIVNPLNRISIHEIMQDDWFK-VDLPEYL 265 Query: 310 LDSHL 314 L L Sbjct: 266 LPPDL 270 >5D9K-A nrPDB Length = 330 Score = 253 bits (646), Expect = 9e-68, Method: Composition-based stats. Identities = 87/325 (26%), Positives = 137/325 (42%), Gaps = 49/325 (15%) Query: 3 KDGLCRAD-QQYECVAEIGEGAYGKVFKARDLK--NGGRFVALKRVRVQTGEEGMPLSTI 59 K+G +AD Q+E + +G+G++GKVF + + + + A+K ++ T + + T Sbjct: 21 KEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTK 80 Query: 60 REVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPGVP 118 E +L HP +V+L E KL L+ + + DL T L K E Sbjct: 81 MERDILVE---VNHPFIVKLHYAFQT-----EGKLYLILDFLRGGDLFTRLSK--EVMFT 130 Query: 119 TETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARI-YSFQMALT 177 E +K + +L LD LHS +++RDLKP+NIL+ G IKL DFGL++ + Sbjct: 131 EEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAY 190 Query: 178 SVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDV-IG 236 S T+ Y APEV+ + + D WS G + EM F+G + + IL +G Sbjct: 191 SFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLG 250 Query: 237 LPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISA----- 291 +P + + LL NPA R+ A Sbjct: 251 MPQF----------------------------LSPEAQSLLRMLFKRNPANRLGAGPDGV 282 Query: 292 YSALSHPYFQDLERCKENLDSHLPP 316 H +F ++ K PP Sbjct: 283 EEIKRHSFFSTIDWNKLYRREIHPP 307 >2J90-A nrPDB Length = 304 Score = 252 bits (645), Expect = 1e-67, Method: Composition-based stats. Identities = 76/306 (24%), Positives = 133/306 (43%), Gaps = 41/306 (13%) Query: 8 RADQQYECVAEIGEGAYGKVFKARDLKNGGRFVA--LKRVRVQTGEEGMPLSTI-REVAV 64 + YE E+G G + V K R G + A +K+ R+ + G+ I REV + Sbjct: 23 MVEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNI 82 Query: 65 LRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQD-LTTYLDKVPEPGVPTETIK 123 LR + HPN++ L D+ + +T + L+ E V L +L + + + Sbjct: 83 LREIR---HPNIITLHDIF-----ENKTDVVLILELVSGGELFDFL--AEKESLTEDEAT 132 Query: 124 DMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSG----QIKLADFGLARIYSFQMALTSV 179 + Q+L G+ +LHS R+ H DLKP+NI++ +IKL DFG+A ++ Sbjct: 133 QFLKQILDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNI 192 Query: 180 VVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPG 239 T + APE++ D+WS+G I + F G + + L I V Sbjct: 193 FGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAV----- 247 Query: 240 EEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPY 299 + E++ ++ EL KD + + L +P +R++ +L H + Sbjct: 248 ------------------NYDFDEEYFSNTSELAKDFIRRLLVKDPKRRMTIAQSLEHSW 289 Query: 300 FQDLER 305 + + R Sbjct: 290 IKAIRR 295 >3EB0-A nrPDB Length = 383 Score = 252 bits (644), Expect = 1e-67, Method: Composition-based stats. Identities = 98/344 (28%), Positives = 164/344 (47%), Gaps = 49/344 (14%) Query: 5 GLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAV 64 GL + ++Y +G G++G V + D+++G RF ALK+V + RE+ + Sbjct: 1 GLETSSKKYSLGKTLGTGSFGIVCEVFDIESGKRF-ALKKVLQDPRYKN------RELDI 53 Query: 65 LRHLETFEHPNVVRLFDVCTVSRTDRETK------------------------------- 93 ++ L +H N+++L D + + Sbjct: 54 MKVL---DHVNIIKLVDYFYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQN 110 Query: 94 --LTLVFEHVDQDLTTYLDKVPEPG--VPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQ 149 L ++ E+V L L G +P I ++QL R + F+HS + HRD+KPQ Sbjct: 111 KYLNVIMEYVPDTLHKVLKSFIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQ 170 Query: 150 NILVTS-SGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSS-YATPVDLWSVGC 207 N+LV S +KL DFG A+ + + + +YRAPE++L ++ Y +DLWS+GC Sbjct: 171 NLLVNSKDNTLKLCDFGSAKKLIPSEPSVAYICSRFYRAPELMLGATEYTPSIDLWSIGC 230 Query: 208 IFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPR-DVALPRQAFHSKSAQPIEKFV 266 +F E+ KPLF G + +DQL +I+ ++G P +E R + F + A+ K + Sbjct: 231 VFGELILGKPLFSGETSIDQLVRIIQIMGTPTKEQMIRMNPHYTEVRFPTLKAKDWRKIL 290 Query: 267 TD-IDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKEN 309 + L DLL + L + P RI+ Y A++HP+F L E+ Sbjct: 291 PEGTPSLAIDLLEQILRYEPDLRINPYEAMAHPFFDHLRNSYES 334 >4UZD-A nrPDB Length = 287 Score = 250 bits (640), Expect = 4e-67, Method: Composition-based stats. Identities = 78/305 (25%), Positives = 138/305 (45%), Gaps = 41/305 (13%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRV-RVQTGEEGMPLSTIREVAVLRHLE 69 + +E +G+G +G V+ AR+ K +ALK + + Q + G+ REV + HL Sbjct: 8 EDFEIGRPLGKGKFGNVYLARE-KQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLR 66 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPGVPTETIKDMMFQ 128 HPN++RL+ + T++ L+ E+ + L K+ + + + + Sbjct: 67 ---HPNILRLYGYFHDA-----TRVYLILEYAPLGTVYRELQKLSK--FDEQRTATYITE 116 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAP 188 L L + HS RV+HRD+KP+N+L+ S+G++K+ADFG + +++ T++ TL Y P Sbjct: 117 LANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWS-VHAPSSRRTTLCGTLDYLPP 175 Query: 189 EVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA 248 E++ + VDLWS+G + E KP F ++ + +I V Sbjct: 176 EMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFT----------- 224 Query: 249 LPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKE 308 F + E +DL+ + L NP++R L HP+ Sbjct: 225 ----------------FPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSKPS 268 Query: 309 NLDSH 313 N + Sbjct: 269 NCQNK 273 >6FD3-A nrPDB Length = 300 Score = 250 bits (640), Expect = 5e-67, Method: Composition-based stats. Identities = 85/315 (26%), Positives = 150/315 (47%), Gaps = 39/315 (12%) Query: 9 ADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHL 68 ++Y +IG+GA G V+ A D+ G VA+K++ +Q ++ I E+ V+R Sbjct: 20 PKKKYTRFEKIGQGASGTVYTALDIATGQE-VAIKQMNLQ--QQPKKELIINEILVMRE- 75 Query: 69 ETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQ 128 ++PN+V D V +L +V E++ T D V E + I + + Sbjct: 76 --NKNPNIVNYLDSYLVG-----DELWVVMEYLAGGSLT--DVVTETCMDEGQIAAVCRE 126 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGL-ARIYSFQMALTSVVVTLWYRA 187 L+ LDFLHS++V+HRD+K NIL+ G +KL DFG A+I Q +++V T ++ A Sbjct: 127 CLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMA 186 Query: 188 PEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDV 247 PEV+ + +Y VD+WS+G + EM +P + + + L I Sbjct: 187 PEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLI---------------- 230 Query: 248 ALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCK 307 + + P + + + +D L +CL + +R SA L HP+ + L++ Sbjct: 231 --------ATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLK-LDKPL 281 Query: 308 ENLDSHLPPSQNTSE 322 +L + ++ + Sbjct: 282 SSLTPLIIAAKEAIK 296 >5ZTN-A nrPDB Length = 429 Score = 250 bits (639), Expect = 6e-67, Method: Composition-based stats. Identities = 89/335 (26%), Positives = 153/335 (45%), Gaps = 42/335 (12%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETF 71 +YE + IG+G++G+V KA D K + VALK VR E+ E+ +L HL Sbjct: 98 RYEVLKVIGKGSFGQVVKAYDHKV-HQHVALKMVR---NEKRFHRQAAEEIRILEHLRKQ 153 Query: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLR 131 + N + + + + + + FE + +L + K G ++ +L+ Sbjct: 154 DKDNTMNV--IHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQ 211 Query: 132 GLDFLHSHRVVHRDLKPQNILVTSSGQ--IKLADFGLARIYSFQMALTSVVVTLWYRAPE 189 LD LH +R++H DLKP+NIL+ G+ IK+ DFG + + + + + +YRAPE Sbjct: 212 CLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCY--EHQRVYTYIQSRFYRAPE 269 Query: 190 VLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEE-------- 241 V+L + Y P+D+WS+GCI AE+ PL G + DQL +++++G+P ++ Sbjct: 270 VILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRA 329 Query: 242 -DWPRDVALPRQAF-----------------------HSKSAQPIEKFVTDIDELGKDLL 277 ++ PR +S + D L D L Sbjct: 330 KNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFL 389 Query: 278 LKCLTFNPAKRISAYSALSHPYFQDLERCKENLDS 312 +CL ++PA R++ AL HP+ + + Sbjct: 390 KQCLEWDPAVRMTPGQALRHPWLRRRLPKPPTGEK 424 >3D2K-A nrPDB Length = 272 Score = 249 bits (637), Expect = 9e-67, Method: Composition-based stats. Identities = 73/293 (24%), Positives = 135/293 (46%), Gaps = 41/293 (13%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRV-RVQTGEEGMPLSTIREVAVLRHLE 69 + ++ +G+G +G V+ AR+ + +ALK + + Q + G+ REV + HL Sbjct: 12 EDFDIGRPLGKGKFGNVYLARERQ-SKFILALKVLFKTQLEKAGVEHQLRREVEIQSHLR 70 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPGVPTETIKDMMFQ 128 HPN++RL+ + T++ L+ E+ + L K+ + + + Sbjct: 71 ---HPNILRLYGYFHDA-----TRVYLILEYAPLGTVYRELQKLSR--FDEQRTATYITE 120 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAP 188 L L + HS RV+HRD+KP+N+L+ S+G++K+ADFG + +++ T++ TL Y P Sbjct: 121 LANALSYCHSKRVIHRDIKPENLLLGSNGELKIADFGWS-VHAPSSRRTTLCGTLDYLPP 179 Query: 189 EVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA 248 E++ + VDLWS+G + E P F + + +I V Sbjct: 180 EMIEGRMHDEKVDLWSLGVLCYEFLVGMPPFEAHTYQETYRRISRVEFT----------- 228 Query: 249 LPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQ 301 F + E +DL+ + L N ++R++ L HP+ + Sbjct: 229 ----------------FPDFVTEGARDLISRLLKHNASQRLTLAEVLEHPWIK 265 >5ES1-A nrPDB Length = 328 Score = 247 bits (631), Expect = 5e-66, Method: Composition-based stats. Identities = 72/306 (23%), Positives = 122/306 (39%), Gaps = 40/306 (13%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETF 71 Y + IG+G + KV AR + GR VA+K + REV +++ Sbjct: 16 NYRLLRTIGKGNFAKVKLARHILT-GREVAIKIIDKTQLNPSSLQKLFREVRIMK---GL 71 Query: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPGVPTETIKDMMFQLL 130 HPN+V+LF+V +T L LV E+ ++ YL V + + + Q++ Sbjct: 72 NHPNIVKLFEVIETEKT-----LYLVMEYASAGEVFDYL--VSHGRMKEKEARAKFRQIV 124 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEV 190 + + H +VHRDLK +N+L+ + IK+ADFG + ++ L + + Y APE+ Sbjct: 125 SAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPEL 184 Query: 191 LLQSSYATP-VDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVAL 249 Y P VD+WS+G I + F G + + ++L Sbjct: 185 FQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFY-------- 236 Query: 250 PRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKEN 309 + + +L + L NPAKR + + + +E Sbjct: 237 -------------------MSTDCESILRRFLVLNPAKRCTLEQIMKDKWINIGYEGEEL 277 Query: 310 LDSHLP 315 P Sbjct: 278 KPYTEP 283 >3GUB-A nrPDB Length = 295 Score = 247 bits (630), Expect = 6e-66, Method: Composition-based stats. Identities = 74/309 (23%), Positives = 140/309 (45%), Gaps = 41/309 (13%) Query: 7 CRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVA--LKRVRVQTGEEGM-PLSTIREVA 63 D Y+ E+G G + V K R+ G ++ A +K+ R ++ G+ REV+ Sbjct: 7 ENVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVS 66 Query: 64 VLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPGVPTETI 122 +L+ ++ HPNV+ L +V + +T + L+ E V +L +L + + E Sbjct: 67 ILKEIQ---HPNVITLHEVY-----ENKTDVILIGELVAGGELFDFL--AEKESLTEEEA 116 Query: 123 KDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSG----QIKLADFGLARIYSFQMALTS 178 + + Q+L G+ +LHS ++ H DLKP+NI++ +IK+ DFGLA F + Sbjct: 117 TEFLKQILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKN 176 Query: 179 VVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLP 238 + T + APE++ D+WS+G I + F G + + L + V Sbjct: 177 IFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAV---- 232 Query: 239 GEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHP 298 + + +++ ++ L KD + + L +P KR++ +L HP Sbjct: 233 -------------------NYEFEDEYFSNTSALAKDFIRRLLVKDPKKRMTIQDSLQHP 273 Query: 299 YFQDLERCK 307 + + + + Sbjct: 274 WIKPKDTQQ 282 >4L42-A nrPDB Length = 346 Score = 246 bits (628), Expect = 1e-65, Method: Composition-based stats. Identities = 77/316 (24%), Positives = 130/316 (41%), Gaps = 50/316 (15%) Query: 13 YECVAEIGEGAYGKVFKARDL--KNGGRFVALKRVR----VQTGEEGMPLSTIREVAVLR 66 +E + +G+G YGKVF+ R + N G+ A+K ++ V+ ++ R + Sbjct: 20 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNI---- 75 Query: 67 HLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMM 126 LE +HP +V L KL L+ E++ ++ E +T + Sbjct: 76 -LEEVKHPFIVDLIYAFQTG-----GKLYLILEYLSGG-ELFMQLEREGIFMEDTACFYL 128 Query: 127 FQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARI-YSFQMALTSVVVTLWY 185 ++ L LH +++RDLKP+NI++ G +KL DFGL + + T+ Y Sbjct: 129 AEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEY 188 Query: 186 RAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPR 245 APE+L++S + VD WS+G + +M P F G + + KIL Sbjct: 189 MAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKC----------- 237 Query: 246 DVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRI-----SAYSALSHPYF 300 + + +DLL K L N A R+ A +HP+F Sbjct: 238 ----------------KLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFF 281 Query: 301 QDLERCKENLDSHLPP 316 + + + PP Sbjct: 282 RHINWEELLARKVEPP 297 >3H4J-B nrPDB Length = 336 Score = 246 bits (628), Expect = 1e-65, Method: Composition-based stats. Identities = 71/291 (24%), Positives = 130/291 (44%), Gaps = 40/291 (13%) Query: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEE-GMPLSTIREVAVLRHLETF 71 Y +GEG++GKV A K + VALK + Q ++ M + RE++ L+ L Sbjct: 11 YIIRETLGEGSFGKVKLATHYKTQQK-VALKFISRQLLKKSDMHMRVEREISYLKLLR-- 67 Query: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLR 131 HP++++L+DV T T + +V E+ +L Y+ V + + + + Q++ Sbjct: 68 -HPHIIKLYDVITTP-----TDIVMVIEYAGGELFDYI--VEKKRMTEDEGRRFFQQIIC 119 Query: 132 GLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVL 191 +++ H H++VHRDLKP+N+L+ + +K+ADFGL+ I + L + + Y APEV+ Sbjct: 120 AIEYCHRHKIVHRDLKPENLLLDDNLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVI 179 Query: 192 LQSSY-ATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALP 250 Y VD+WS G + M + F + K+ + + Sbjct: 180 NGKLYAGPEVDVWSCGIVLYVMLVGRLPFDDEFIPNLFKKVNSCVYV------------- 226 Query: 251 RQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQ 301 + + L+ + + +P +RI+ P+F Sbjct: 227 --------------MPDFLSPGAQSLIRRMIVADPMQRITIQEIRRDPWFN 263 >3TAC-A nrPDB Length = 361 Score = 245 bits (627), Expect = 1e-65, Method: Composition-based stats. Identities = 81/317 (25%), Positives = 136/317 (42%), Gaps = 45/317 (14%) Query: 9 ADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEG---MPLSTIREVAVL 65 + YE IG+G + V + + + G +F A+K V V RE ++ Sbjct: 24 FEDVYELCEVIGKGPFSVVRRCINRETGQQF-AVKIVDVAKFTSSPGLSTEDLKREASIC 82 Query: 66 RHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGV--PTETI 122 L+ HP++V L + + L +VFE +D DL + K + G Sbjct: 83 HMLK---HPHIVELLE-----TYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVA 134 Query: 123 KDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTS---SGQIKLADFGLA-RIYSFQMALTS 178 M Q+L L + H + ++HRD+KP +L+ S S +KL FG+A ++ + Sbjct: 135 SHYMRQILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGG 194 Query: 179 VVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLP 238 V T + APEV+ + Y PVD+W G I + F G+ + ++ + I Sbjct: 195 RVGTPHFMAPEVVKREPYGKPVDVWGCGVILFILLSGCLPFYGTKE-----RLFEGI--- 246 Query: 239 GEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHP 298 + + + I E KDL+ + L +PA+RI+ Y AL+HP Sbjct: 247 ----------------IKGKYKMNPRQWSHISESAKDLVRRMLMLDPAERITVYEALNHP 290 Query: 299 YFQDLERCKENLDSHLP 315 + ++ +R HLP Sbjct: 291 WLKERDRYAY--KIHLP 305 >2YAB-A nrPDB Length = 361 Score = 245 bits (627), Expect = 1e-65, Method: Composition-based stats. Identities = 79/315 (25%), Positives = 133/315 (42%), Gaps = 41/315 (13%) Query: 7 CRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVA--LKRVRVQTGEEGMPLSTI-REVA 63 + + Y+ E+G G + V K R+ G + A +K+ + + G+ I REV+ Sbjct: 8 QKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIEREVS 67 Query: 64 VLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQD-LTTYLDKVPEPGVPTETI 122 +LR HPN++ L DV + T + L+ E V L +L + + E Sbjct: 68 ILRQ---VLHPNIITLHDVY-----ENRTDVVLILELVSGGELFDFL--AQKESLSEEEA 117 Query: 123 KDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSG----QIKLADFGLARIYSFQMALTS 178 + Q+L G+++LH+ ++ H DLKP+NI++ IKL DFGLA + + Sbjct: 118 TSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKN 177 Query: 179 VVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLP 238 + T + APE++ D+WS+G I + F G + + L I V Sbjct: 178 IFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAV---- 233 Query: 239 GEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHP 298 S E+F + EL KD + K L KR++ AL HP Sbjct: 234 -------------------SYDFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHP 274 Query: 299 YFQDLERCKENLDSH 313 + ++ + + Sbjct: 275 WITPVDTQQAMVRRE 289 >2W4O-A nrPDB Length = 349 Score = 245 bits (627), Expect = 1e-65, Method: Composition-based stats. Identities = 79/293 (26%), Positives = 134/293 (45%), Gaps = 43/293 (14%) Query: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 +E +E+G GA V++ + K + ALK ++ ++ + E+ VL L Sbjct: 55 FEVESELGRGATSIVYRCKQ-KGTQKPYALKVLKKTVDKKIVRT----EIGVLLRLS--- 106 Query: 73 HPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGV-PTETIKDMMFQLLR 131 HPN+++L ++ T+++LV E V D++ E G D + Q+L Sbjct: 107 HPNIIKLKEIFETP-----TEISLVLELVTGG--ELFDRIVEKGYYSERDAADAVKQILE 159 Query: 132 GLDFLHSHRVVHRDLKPQNILVTS---SGQIKLADFGLARIYSFQMALTSVVVTLWYRAP 188 + +LH + +VHRDLKP+N+L + +K+ADFGL++I Q+ + +V T Y AP Sbjct: 160 AVAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAP 219 Query: 189 EVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGS-SDVDQLGKILDVIGLPGEEDWPRDV 247 E+L +Y VD+WSVG I + F D +IL+ Sbjct: 220 EILRGCAYGPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNC------------- 266 Query: 248 ALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 I + ++ KDL+ K + +P KR++ + AL HP+ Sbjct: 267 ----------EYYFISPWWDEVSLNAKDLVRKLIVLDPKKRLTTFQALQHPWV 309 >2JAM-A nrPDB Length = 304 Score = 245 bits (625), Expect = 2e-65, Method: Composition-based stats. Identities = 78/293 (26%), Positives = 130/293 (44%), Gaps = 41/293 (13%) Query: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 + + +G GA+ +VF + + G+ ALK ++ L E+AVL+ ++ Sbjct: 11 FIFMEVLGSGAFSEVFLVKQ-RLTGKLFALKCIKKSPAFRDSSLE--NEIAVLKKIK--- 64 Query: 73 HPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGV-PTETIKDMMFQLLR 131 H N+V L D+ + T LV + V D++ E GV + ++ Q+L Sbjct: 65 HENIVTLEDIYEST-----THYYLVMQLVSGG--ELFDRILERGVYTEKDASLVIQQVLS 117 Query: 132 GLDFLHSHRVVHRDLKPQNILV---TSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAP 188 + +LH + +VHRDLKP+N+L + +I + DFGL+++ + +++ T Y AP Sbjct: 118 AVKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGI-MSTACGTPGYVAP 176 Query: 189 EVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA 248 EVL Q Y+ VD WS+G I + P F ++ KI + Sbjct: 177 EVLAQKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGY------------- 223 Query: 249 LPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQ 301 + F DI E KD + L +P +R + ALSHP+ Sbjct: 224 ----------YEFESPFWDDISESAKDFICHLLEKDPNERYTCEKALSHPWID 266 >4RLP-A nrPDB Length = 288 Score = 244 bits (624), Expect = 4e-65, Method: Composition-based stats. Identities = 77/316 (24%), Positives = 130/316 (41%), Gaps = 50/316 (15%) Query: 13 YECVAEIGEGAYGKVFKARDL--KNGGRFVALKRVR----VQTGEEGMPLSTIREVAVLR 66 +E + +G+G YGKVF+ R + N G+ A+K ++ V+ ++ R + Sbjct: 7 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNI---- 62 Query: 67 HLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMM 126 LE +HP +V L KL L+ E++ ++ E +T + Sbjct: 63 -LEEVKHPFIVDLIYAFQTG-----GKLYLILEYLSGG-ELFMQLEREGIFMEDTACFYL 115 Query: 127 FQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARI-YSFQMALTSVVVTLWY 185 ++ L LH +++RDLKP+NI++ G +KL DFGL + + T+ Y Sbjct: 116 AEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEY 175 Query: 186 RAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPR 245 APE+L++S + VD WS+G + +M P F G + + KIL Sbjct: 176 MAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKC----------- 224 Query: 246 DVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRI-----SAYSALSHPYF 300 + + +DLL K L N A R+ A +HP+F Sbjct: 225 ----------------KLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFF 268 Query: 301 QDLERCKENLDSHLPP 316 + + + PP Sbjct: 269 RHINWEELLARKVEPP 284 >2QNJ-A nrPDB Length = 328 Score = 244 bits (623), Expect = 4e-65, Method: Composition-based stats. Identities = 73/313 (23%), Positives = 124/313 (39%), Gaps = 40/313 (12%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETF 71 Y + IG+G + KV AR + GR VA+K + REV +++ L Sbjct: 13 NYRLLKTIGKGNFAKVKLARHILT-GREVAIKIIDKTQLNPTSLQKLFREVRIMKIL--- 68 Query: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQD-LTTYLDKVPEPGVPTETIKDMMFQLL 130 HPN+V+LF+V +T L L+ E+ + YL V + + + Q++ Sbjct: 69 NHPNIVKLFEVIETEKT-----LYLIMEYASGGEVFDYL--VAHGRMKEKEARSKFRQIV 121 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEV 190 + + H R+VHRDLK +N+L+ + IK+ADFG + ++ L + + Y APE+ Sbjct: 122 SAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPEL 181 Query: 191 LLQSSYATP-VDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVAL 249 Y P VD+WS+G I + F G + + ++L Sbjct: 182 FQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFY-------- 233 Query: 250 PRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKEN 309 + ++LL + L NP KR + + + E Sbjct: 234 -------------------MSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDEL 274 Query: 310 LDSHLPPSQNTSE 322 P + + Sbjct: 275 KPFVEPELDISDQ 287 >2Z7Q-A nrPDB Length = 321 Score = 244 bits (623), Expect = 5e-65, Method: Composition-based stats. Identities = 89/325 (27%), Positives = 137/325 (42%), Gaps = 49/325 (15%) Query: 3 KDGLCRAD-QQYECVAEIGEGAYGKVFKARDLK--NGGRFVALKRVRVQTGEEGMPLSTI 59 K G +AD +E + +G+G++GKVF R + + G A+K ++ T + + T Sbjct: 19 KAGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTK 78 Query: 60 REVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPGVP 118 E +L HP VV+L E KL L+ + + DL T L K E Sbjct: 79 MERDIL---ADVNHPFVVKLHYAFQT-----EGKLYLILDFLRGGDLFTRLSK--EVMFT 128 Query: 119 TETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARI-YSFQMALT 177 E +K + +L GLD LHS +++RDLKP+NIL+ G IKL DFGL++ + Sbjct: 129 EEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAY 188 Query: 178 SVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDV-IG 236 S T+ Y APEV+ + ++ D WS G + EM F+G + + IL +G Sbjct: 189 SFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLG 248 Query: 237 LPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRI-----SA 291 +P + + LL NPA R+ A Sbjct: 249 MPQF----------------------------LSTEAQSLLRALFKRNPANRLGSGPDGA 280 Query: 292 YSALSHPYFQDLERCKENLDSHLPP 316 H ++ ++ K PP Sbjct: 281 EEIKRHVFYSTIDWNKLYRREIKPP 305 >5KZ7-A nrPDB Length = 346 Score = 244 bits (622), Expect = 5e-65, Method: Composition-based stats. Identities = 74/306 (24%), Positives = 122/306 (39%), Gaps = 40/306 (13%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETF 71 Y + IG+G + KV AR + G VA+K + REV +++ L Sbjct: 34 NYRLLKTIGKGNFAKVKLARHILTGKE-VAVKIIDKTQLNSSSLQKLFREVRIMKVL--- 89 Query: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQD-LTTYLDKVPEPGVPTETIKDMMFQLL 130 HPN+V+LF+V +T L LV E+ + YL V + + + Q++ Sbjct: 90 NHPNIVKLFEVIETEKT-----LYLVMEYASGGEVFDYL--VAHGRMKEKEARAKFRQIV 142 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEV 190 + + H +VHRDLK +N+L+ + IK+ADFG + ++F L + + Y APE+ Sbjct: 143 SAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPEL 202 Query: 191 LLQSSYATP-VDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVAL 249 Y P VD+WS+G I + F G + + ++L Sbjct: 203 FQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFY-------- 254 Query: 250 PRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKEN 309 + ++LL K L NP+KR + + + E Sbjct: 255 -------------------MSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDEL 295 Query: 310 LDSHLP 315 P Sbjct: 296 KPYVEP 301 >2I6L-A nrPDB Length = 320 Score = 244 bits (622), Expect = 5e-65, Method: Composition-based stats. Identities = 101/308 (32%), Positives = 167/308 (54%), Gaps = 27/308 (8%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 +Y + +G G G VF A D R VA+K++ + + +RE+ ++R L Sbjct: 11 SRYMDLKPLGCGGNGLVFSAVDNDCDKR-VAIKKIVLTDPQSV--KHALREIKIIRRL-- 65 Query: 71 FEHPNVVRLFDVCTVSRTD---------RETKLTLVFEHVDQDLTTYLDKVPEPGVPTET 121 +H N+V++F++ S + + +V E+++ DL L++ P + E Sbjct: 66 -DHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGP---LLEEH 121 Query: 122 IKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVT-SSGQIKLADFGLARI----YSFQMAL 176 + M+QLLRGL ++HS V+HRDLKP N+ + +K+ DFGLARI YS + L Sbjct: 122 ARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHL 181 Query: 177 TSVVVTLWYRAPEVLLQ-SSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVI 235 + +VT WYR+P +LL ++Y +D+W+ GCIFAEM K LF G+ +++Q+ IL+ I Sbjct: 182 SEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESI 241 Query: 236 GLPGEEDWPRDVALPRQAFHS---KSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAY 292 + EED +++ + + +P+ + + I D L + LTF+P R++A Sbjct: 242 PVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREAVDFLEQILTFSPMDRLTAE 301 Query: 293 SALSHPYF 300 ALSHPY Sbjct: 302 EALSHPYM 309 >2Y7J-A nrPDB Length = 365 Score = 243 bits (621), Expect = 6e-65, Method: Composition-based stats. Identities = 83/305 (27%), Positives = 128/305 (41%), Gaps = 46/305 (15%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGE------EGMPLSTIREVAV 64 Q+Y+ IG G V + G F A+K + V E + +T RE + Sbjct: 94 QKYDPKDVIGRGVSSVVRRCVHRATGHEF-AVKIMEVTAERLSPEQLEEVREATRRETHI 152 Query: 65 LRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPGVPTETIK 123 LR + HP+++ L D S + LVF+ + +L YL + + + + Sbjct: 153 LRQVAG--HPHIITLIDSYESSSF-----MFLVFDLMRKGELFDYL--TEKVALSEKETR 203 Query: 124 DMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTL 183 +M LL + FLH++ +VHRDLKP+NIL+ + QI+L+DFG + L + T Sbjct: 204 SIMRSLLEAVSFLHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEPGEKLRELCGTP 263 Query: 184 WYRAPEVLLQS------SYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGL 237 Y APE+L S Y VDLW+ G I + P F + L I++ Sbjct: 264 GYLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEG--- 320 Query: 238 PGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSH 297 Q D KDL+ + L +P R++A AL H Sbjct: 321 --------------------QYQFSSPEWDDRSSTVKDLISRLLQVDPEARLTAEQALQH 360 Query: 298 PYFQD 302 P+F+ Sbjct: 361 PFFER 365 >1FOT-A nrPDB Length = 318 Score = 243 bits (621), Expect = 8e-65, Method: Composition-based stats. Identities = 70/318 (22%), Positives = 137/318 (43%), Gaps = 45/318 (14%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 Q ++ + +G G++G+V R N GR+ A+K ++ + + + ++ L Sbjct: 6 QDFQILRTLGTGSFGRVHLIRSRHN-GRYYAMKVLKKEIVVRLKQVEHTNDERLM--LSI 62 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQD-LTTYLDKVPEPGVPTETIKDMMFQL 129 HP ++R++ ++ ++ ++ ++++ L + L K P K ++ Sbjct: 63 VTHPFIIRMWGTFQDAQ-----QIFMIMDYIEGGELFSLLRKSQR--FPNPVAKFYAAEV 115 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPE 189 L++LHS +++RDLKP+NIL+ +G IK+ DFG A+ ++ T Y APE Sbjct: 116 CLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPD--VTYTLCGTPDYIAPE 173 Query: 190 VLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVAL 249 V+ Y +D WS G + EM F S+ + KIL+ Sbjct: 174 VVSTKPYNKSIDWWSFGILIYEMLAGYTPFYDSNTMKTYEKILNA--------------- 218 Query: 250 PRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRI-----SAYSALSHPYFQDLE 304 +F +E KDLL + +T + ++R+ +HP+F+++ Sbjct: 219 ------------ELRFPPFFNEDVKDLLSRLITRDLSQRLGNLQNGTEDVKNHPWFKEVV 266 Query: 305 RCKENLDSHLPPSQNTSE 322 K + P + + Sbjct: 267 WEKLLSRNIETPYEPPIQ 284 >3Q53-A nrPDB Length = 306 Score = 242 bits (619), Expect = 1e-64, Method: Composition-based stats. Identities = 82/317 (25%), Positives = 150/317 (47%), Gaps = 39/317 (12%) Query: 9 ADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHL 68 ++Y +IG+GA G V+ A D+ G VA++++ +Q ++ I E+ V+R Sbjct: 19 PKKKYTRFEKIGQGASGTVYTAMDVATGQE-VAIRQMNLQ--QQPKKELIINEILVMRE- 74 Query: 69 ETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQ 128 ++PN+V D V +L +V E++ T D V E + I + + Sbjct: 75 --NKNPNIVNYLDSYLVG-----DELWVVMEYLAGGSLT--DVVTETCMDEGQIAAVCRE 125 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGL-ARIYSFQMALTSVVVTLWYRA 187 L+ L+FLHS++V+HRD+K NIL+ G +KL DFG A+I Q +++V T ++ A Sbjct: 126 CLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMA 185 Query: 188 PEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDV 247 PEV+ + +Y VD+WS+G + EM +P + + + L I Sbjct: 186 PEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLI---------------- 229 Query: 248 ALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCK 307 + + P + + + +D L +CL + KR SA + H + + + + Sbjct: 230 --------ATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELIQHQFLK-IAKPL 280 Query: 308 ENLDSHLPPSQNTSELN 324 +L + ++ ++ N Sbjct: 281 SSLTPLIAAAKEATKNN 297 >2F57-A nrPDB Length = 317 Score = 242 bits (619), Expect = 1e-64, Method: Composition-based stats. Identities = 79/285 (27%), Positives = 136/285 (47%), Gaps = 38/285 (13%) Query: 18 EIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVV 77 +IGEG+ G V A + K+ G+ VA+K++ ++ ++ EV ++R + H NVV Sbjct: 52 KIGEGSTGIVCIATE-KHTGKQVAVKKMDLR--KQQRRELLFNEVVIMR---DYHHDNVV 105 Query: 78 RLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLH 137 ++ V +L +V E ++ T D V + E I + +LR L +LH Sbjct: 106 DMYSSYLVG-----DELWVVMEFLEGGALT--DIVTHTRMNEEQIATVCLSVLRALSYLH 158 Query: 138 SHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQM-ALTSVVVTLWYRAPEVLLQSSY 196 + V+HRD+K +IL+TS G+IKL+DFG S ++ S+V T ++ APEV+ + Y Sbjct: 159 NQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPY 218 Query: 197 ATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHS 256 T VD+WS+G + EM +P + + + +I D + Sbjct: 219 GTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSL--------------------- 257 Query: 257 KSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQ 301 P K + + + + L L P++R +A L HP+ + Sbjct: 258 ---PPRVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLK 299 >4FIE-A nrPDB Length = 423 Score = 242 bits (619), Expect = 1e-64, Method: Composition-based stats. Identities = 75/286 (26%), Positives = 134/286 (46%), Gaps = 38/286 (13%) Query: 18 EIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVV 77 +IGEG+ G V A +++ G+ VA+K++ ++ ++ EV ++R ++H NVV Sbjct: 158 KIGEGSTGIVCIAT-VRSSGKLVAVKKMDLR--KQQRRELLFNEVVIMR---DYQHENVV 211 Query: 78 RLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLH 137 +++ V +L +V E ++ T D V + E I + +L+ L LH Sbjct: 212 EMYNSYLVG-----DELWVVMEFLEGGALT--DIVTHTRMNEEQIAAVCLAVLQALSVLH 264 Query: 138 SHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMAL-TSVVVTLWYRAPEVLLQSSY 196 + V+HRD+K +IL+T G++KL+DFG S ++ S+V T ++ APE++ + Y Sbjct: 265 AQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPY 324 Query: 197 ATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHS 256 VD+WS+G + EM +P + + + I D Sbjct: 325 GPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRD----------------------- 361 Query: 257 KSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQD 302 + P K + + K L + L +PA+R +A L HP+ Sbjct: 362 -NLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAK 406 >4NIF-A nrPDB Length = 333 Score = 242 bits (617), Expect = 2e-64, Method: Composition-based stats. Identities = 79/307 (25%), Positives = 124/307 (40%), Gaps = 42/307 (13%) Query: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 Y IG G+Y + + K A+K + + E+ +L L + Sbjct: 10 YVVKETIGVGSYSECKRCVH-KATNMEYAVKVIDKSKRDPSE------EIEIL--LRYGQ 60 Query: 73 HPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGV-PTETIKDMMFQLLR 131 HPN++ L DV D + LV E + LDK+ ++ + + Sbjct: 61 HPNIITLKDVY-----DDGKHVYLVTELMRGG--ELLDKILRQKFFSEREASFVLHTIGK 113 Query: 132 GLDFLHSHRVVHRDLKPQNIL-VTSSGQ---IKLADFGLARIY-SFQMALTSVVVTLWYR 186 +++LHS VVHRDLKP NIL V SG +++ DFG A+ + L + T + Sbjct: 114 TVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFV 173 Query: 187 APEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRD 246 APEVL + Y D+WS+G + M F + D +IL IG Sbjct: 174 APEVLKRQGYDEGCDIWSLGILLYTMLAGYTPF-ANGPSDTPEEILTRIG---------- 222 Query: 247 VALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERC 306 S + E KDL+ K L +P +R++A L HP+ ++ Sbjct: 223 ---------SGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPWVTQKDKL 273 Query: 307 KENLDSH 313 ++ SH Sbjct: 274 PQSQLSH 280 >4CSV-A nrPDB Length = 275 Score = 241 bits (616), Expect = 3e-64, Method: Composition-based stats. Identities = 66/299 (22%), Positives = 131/299 (43%), Gaps = 42/299 (14%) Query: 2 EKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIRE 61 D + ++G G +G+V++ + +N VA+K ++ T ++E Sbjct: 2 PHDKWEIPRSEITLERKLGSGQFGEVYEGKW-RNYNIEVAVKTLKEGTMS---VEEFLQE 57 Query: 62 VAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPGVPTE 120 +++ L+ HPN+V+L+ VCT +E + ++ E++ L YL V + Sbjct: 58 AQIMKKLK---HPNLVQLYGVCT-----KEPPIYIITEYMSHGSLLDYLRDCEGHTVNAQ 109 Query: 121 TIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQ--MALTS 178 + DM Q+ G+ +L S +HRDL +N LV + +K+ADFGLAR+ + A Sbjct: 110 ALLDMAAQVASGMAYLESQNFIHRDLAARNCLVGENNVVKVADFGLARLINEDEYTARAG 169 Query: 179 VVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILDVIGL 237 + + APE + + ++ D+W+ G + E+F + + G S + + ++ + Sbjct: 170 AKFPIKWTAPEAISYNRFSIKSDVWAFGILLWEIFTYGQVPYPGMSGSEVIEQVERGYRM 229 Query: 238 PGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALS 296 P + P ++ +L+L+C +P +R + L Sbjct: 230 PRPQGCPEEI--------------------------YELMLQCWNKSPEERPTFAETLH 262 >4JDH-A nrPDB Length = 346 Score = 241 bits (615), Expect = 4e-64, Method: Composition-based stats. Identities = 75/286 (26%), Positives = 134/286 (46%), Gaps = 38/286 (13%) Query: 18 EIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVV 77 +IGEG+ G V A +++ G+ VA+K++ ++ ++ EV ++R ++H NVV Sbjct: 81 KIGEGSTGIVCIAT-VRSSGKLVAVKKMDLR--KQQRRELLFNEVVIMR---DYQHENVV 134 Query: 78 RLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLH 137 +++ V +L +V E ++ T D V + E I + +L+ L LH Sbjct: 135 EMYNSYLVG-----DELWVVMEFLEGGALT--DIVTHTRMNEEQIAAVCLAVLQALSVLH 187 Query: 138 SHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMAL-TSVVVTLWYRAPEVLLQSSY 196 + V+HRD+K +IL+T G++KL+DFG S ++ S+V T ++ APE++ + Y Sbjct: 188 AQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPY 247 Query: 197 ATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHS 256 VD+WS+G + EM +P + + + I D Sbjct: 248 GPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRD----------------------- 284 Query: 257 KSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQD 302 + P K + + K L + L +PA+R +A L HP+ Sbjct: 285 -NLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAK 329 >5XZW-A nrPDB Length = 471 Score = 241 bits (615), Expect = 4e-64, Method: Composition-based stats. Identities = 78/309 (25%), Positives = 131/309 (42%), Gaps = 52/309 (16%) Query: 11 QQYECV-AEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLE 69 + + + +G+GA+ V KA + + G+ A+K + + G RE+ VL+ L Sbjct: 195 KDFSIIDEVVGQGAFATVKKAIE-RTTGKTFAVKIISKRKVI-GNMDGVTRELEVLQKL- 251 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPGVPTETIKDMMFQ 128 HP +VRL + + +V E V DL ++ V + +++ Q Sbjct: 252 --NHPRIVRLKGFYEDTES-----YYMVMEFVSGGDLMDFV--AAHGAVGEDAGREISRQ 302 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQ--IKLADFGLARIYSFQMALTSVVVTLWYR 186 +L + ++HS + HRDLKP NIL+ +K+ DFGLA++ + + TL Y Sbjct: 303 ILTAIKYIHSMGISHRDLKPDNILIEQDDPVLVKITDFGLAKVQGNGSFMKTFCGTLAYV 362 Query: 187 APEVLLQS-------------SYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILD 233 APEV+ Y++ VD+WS+GC+ + F GS+ +I Sbjct: 363 APEVIRGKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGR 422 Query: 234 VIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYS 293 S P++ F I E +D + L +P R +A Sbjct: 423 G---------------------SYHEGPLKDF--RISEEARDFIDSLLQVDPNNRSTAAK 459 Query: 294 ALSHPYFQD 302 AL+HP+ D Sbjct: 460 ALNHPWIVD 468 >5JZN-A nrPDB Length = 280 Score = 240 bits (614), Expect = 4e-64, Method: Composition-based stats. Identities = 82/310 (26%), Positives = 132/310 (42%), Gaps = 43/310 (13%) Query: 1 MEKDGLCRA---DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLS 57 + ++G ++Y+ IG+G + V + + ++ R ALK ++ G Sbjct: 6 VSEEGFQIPATITERYKVGRTIGDGNFAVVKECVE-RSTAREYALKIIKKSKCR-GKEHM 63 Query: 58 TIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPG 116 EV++LR ++ HPN+V L + D T+L LV E V DL + + Sbjct: 64 IQNEVSILRRVK---HPNIVLLIE-----EMDVPTELYLVMELVKGGDLFDAITSTNK-- 113 Query: 117 VPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILV----TSSGQIKLADFGLARIYSF 172 M++ L + +LHS +VHRD+KP+N+LV S +KL DFGLA I Sbjct: 114 YTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIV-- 171 Query: 173 QMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKIL 232 L +V T Y APE++ ++ Y VD+W+ G I + P FRGS D Sbjct: 172 DGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRGSGD-------- 223 Query: 233 DVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAY 292 D + + ++ + K+L+ L + +R SA Sbjct: 224 -------------DQEVLFDQILMGQVDFPSPYWDNVSDSAKELITMMLLVDVDQRFSAV 270 Query: 293 SALSHPYFQD 302 L HP+ D Sbjct: 271 QVLEHPWVND 280 >4REW-A nrPDB Length = 540 Score = 240 bits (614), Expect = 5e-64, Method: Composition-based stats. Identities = 75/293 (25%), Positives = 122/293 (41%), Gaps = 39/293 (13%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETF 71 Y +G G +GKV + G + VA+K + Q + IR +++L+ F Sbjct: 7 HYILGDTLGVGTFGKVKVGKHELTGHK-VAVKILNRQKIRSLDVVGKIR--REIQNLKLF 63 Query: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQD-LTTYLDKVPEPGVPTETIKDMMFQLL 130 HP++++L+ V + + + +V E+V L Y+ + + + + Q+L Sbjct: 64 RHPHIIKLYQVISTP-----SDIFMVMEYVSGGELFDYI--CKNGRLDEKESRRLFQQIL 116 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEV 190 G+D+ H H VVHRDLKP+N+L+ + K+ADFGL+ + S L + + Y APEV Sbjct: 117 SGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEV 176 Query: 191 LLQSSY-ATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVAL 249 + Y VD+WS G I + F KI D I + P ++ Sbjct: 177 ISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVIS- 235 Query: 250 PRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQD 302 LL L +P KR S H +F+ Sbjct: 236 --------------------------LLKHMLQVDPMKRASIKDIREHEWFKQ 262 >5D7A-A nrPDB Length = 308 Score = 240 bits (614), Expect = 5e-64, Method: Composition-based stats. Identities = 73/298 (24%), Positives = 126/298 (42%), Gaps = 39/298 (13%) Query: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 +E V +G G YG+V+K R +K G+ A+K + V EE +E+ +L+ + Sbjct: 19 FELVELVGNGTYGQVYKGRHVKT-GQLAAIKVMDVTGDEE---EEIKQEINMLK--KYSH 72 Query: 73 HPNVVRLFDVCTVSRTDR-ETKLTLVFEHVD-QDLTTYLDKVPEPGVPTETIKDMMFQLL 130 H N+ + + +L LV E +T + + E I + ++L Sbjct: 73 HRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREIL 132 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQ-MALTSVVVTLWYRAPE 189 RGL LH H+V+HRD+K QN+L+T + ++KL DFG++ + + T ++ APE Sbjct: 133 RGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 192 Query: 190 VLL-----QSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWP 244 V+ ++Y DLWS+G EM P + L I Sbjct: 193 VIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLI------------- 239 Query: 245 RDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQD 302 PR ++ + + + CL N ++R + + HP+ +D Sbjct: 240 -----PRNPAPRLKSKKW-------SKKFQSFIESCLVKNHSQRPATEQLMKHPFIRD 285 >2Q0N-A nrPDB Length = 301 Score = 240 bits (613), Expect = 5e-64, Method: Composition-based stats. Identities = 75/286 (26%), Positives = 134/286 (46%), Gaps = 38/286 (13%) Query: 18 EIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVV 77 +IGEG+ G V A +++ G+ VA+K++ ++ ++ EV ++R ++H NVV Sbjct: 36 KIGEGSTGIVCIAT-VRSSGKLVAVKKMDLR--KQQRRELLFNEVVIMR---DYQHENVV 89 Query: 78 RLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLH 137 +++ V +L +V E ++ T D V + E I + +L+ L LH Sbjct: 90 EMYNSYLVG-----DELWVVMEFLEGGALT--DIVTHTRMNEEQIAAVCLAVLQALSVLH 142 Query: 138 SHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMAL-TSVVVTLWYRAPEVLLQSSY 196 + V+HRD+K +IL+T G++KL+DFG S ++ S+V T ++ APE++ + Y Sbjct: 143 AQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPY 202 Query: 197 ATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHS 256 VD+WS+G + EM +P + + + I D Sbjct: 203 GPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRD----------------------- 239 Query: 257 KSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQD 302 + P K + + K L + L +PA+R +A L HP+ Sbjct: 240 -NLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAK 284 >2A27-A nrPDB Length = 321 Score = 240 bits (613), Expect = 5e-64, Method: Composition-based stats. Identities = 79/315 (25%), Positives = 132/315 (41%), Gaps = 41/315 (13%) Query: 7 CRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVA--LKRVRVQTGEEGMPLSTI-REVA 63 + + Y+ E+G G + V K R+ G + A +K+ + + G+ I REV+ Sbjct: 8 QKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVS 67 Query: 64 VLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQD-LTTYLDKVPEPGVPTETI 122 +LR H NV+ L DV + T + L+ E V L +L + + E Sbjct: 68 ILRQ---VLHHNVITLHDVY-----ENRTDVVLILELVSGGELFDFL--AQKESLSEEEA 117 Query: 123 KDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSG----QIKLADFGLARIYSFQMALTS 178 + Q+L G+++LH+ ++ H DLKP+NI++ IKL DFGLA + + Sbjct: 118 TSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKN 177 Query: 179 VVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLP 238 + T + APE++ D+WS+G I + F G + + L I V Sbjct: 178 IFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAV---- 233 Query: 239 GEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHP 298 S E+F + EL KD + K L KR++ AL HP Sbjct: 234 -------------------SYDFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHP 274 Query: 299 YFQDLERCKENLDSH 313 + ++ + + Sbjct: 275 WITPVDNQQAMVRRE 289 >4XBR-A nrPDB Length = 366 Score = 240 bits (613), Expect = 6e-64, Method: Composition-based stats. Identities = 75/286 (26%), Positives = 134/286 (46%), Gaps = 38/286 (13%) Query: 18 EIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVV 77 +IGEG+ G V A +++ G+ VA+K++ ++ ++ EV ++R ++H NVV Sbjct: 101 KIGEGSTGIVCIAT-VRSSGKLVAVKKMDLR--KQQRRELLFNEVVIMR---DYQHENVV 154 Query: 78 RLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLH 137 +++ V +L +V E ++ T D V + E I + +L+ L LH Sbjct: 155 EMYNSYLVG-----DELWVVMEFLEGGALT--DIVTHTRMNEEQIAAVCLAVLQALSVLH 207 Query: 138 SHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMAL-TSVVVTLWYRAPEVLLQSSY 196 + V+HRD+K +IL+T G++KL+DFG S ++ S+V T ++ APE++ + Y Sbjct: 208 AQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPY 267 Query: 197 ATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHS 256 VD+WS+G + EM +P + + + I D Sbjct: 268 GPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRD----------------------- 304 Query: 257 KSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQD 302 + P K + + K L + L +PA+R +A L HP+ Sbjct: 305 -NLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAK 349 >4CZT-A nrPDB Length = 464 Score = 240 bits (613), Expect = 7e-64, Method: Composition-based stats. Identities = 85/311 (27%), Positives = 136/311 (43%), Gaps = 46/311 (14%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRV-RVQTGEEGMPLSTIREVAVLRHLET 70 +YE +GEG + KV AR+++NG VA+K + + + + M RE++ ++ ++ Sbjct: 12 KYELGRTLGEGTFAKVKFARNVENGDN-VAIKVIDKEKVLKNKMIAQIKREISTMKLIK- 69 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPG-VPTETIKDMMFQL 129 HPNV+R+F+V +TK+ V E V DK+ G + + + QL Sbjct: 70 --HPNVIRMFEV-----MASKTKIYFVLEFVTGG--ELFDKISSNGRLKEDEARKYFQQL 120 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLA---RIYSFQMALTSVVVTLWYR 186 + +D+ HS V HRDLKP+N+L+ ++G +K++DFGL+ + L + T Y Sbjct: 121 INAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYV 180 Query: 187 APEVLLQSSYA-TPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPR 245 APEV+ Y DLWS G I + F S+ KI E P Sbjct: 181 APEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFK-----AEFTCP- 234 Query: 246 DVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLER 305 K L+ + L NPA RI+ + + +F+ + Sbjct: 235 ---------------------PWFSASAKKLIKRILDPNPATRITFAEVIENEWFKKGYK 273 Query: 306 CK--ENLDSHL 314 EN D L Sbjct: 274 APKFENADVSL 284 >2UV2-A nrPDB Length = 325 Score = 240 bits (612), Expect = 7e-64, Method: Composition-based stats. Identities = 81/300 (27%), Positives = 129/300 (43%), Gaps = 41/300 (13%) Query: 7 CRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLR 66 + +E + E+G+GA+GKV+KA++ + A K + ++ EE + E+ +L Sbjct: 33 LNPEDFWEIIGELGDGAFGKVYKAQNKETS-VLAAAKVIDTKSEEEL--EDYMVEIDIL- 88 Query: 67 HLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMM 126 + +HPN+V+L D E L ++ E + E + I+ + Sbjct: 89 --ASCDHPNIVKLLDAFYY-----ENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVC 141 Query: 127 FQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGL-ARIYSFQMALTSVVVTLWY 185 Q L L++LH ++++HRDLK NIL T G IKLADFG+ A+ S + T ++ Sbjct: 142 KQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYW 201 Query: 186 RAPEVLL-----QSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGE 240 APEV++ Y D+WS+G EM +P + + L KI Sbjct: 202 MAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKI--------- 252 Query: 241 EDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 +KS P + KD L KCL N R + L HP+ Sbjct: 253 ---------------AKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFV 297 >6FDY-U nrPDB Length = 276 Score = 240 bits (612), Expect = 8e-64, Method: Composition-based stats. Identities = 80/292 (27%), Positives = 125/292 (42%), Gaps = 37/292 (12%) Query: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 + +G G Y V+KA K+ VA+K V ++ + + + E+ +L+ Sbjct: 13 FILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILK---GIR 69 Query: 73 HPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPGVPTETIKDMMFQLLR 131 HP++V+L D S + L+ E DL+ ++ +P + + M QL Sbjct: 70 HPHIVQLKDFQWDS-----DNIYLIMEFCAGGDLSRFIH--TRRILPEKVARVFMQQLAS 122 Query: 132 GLDFLHSHRVVHRDLKPQNILVT--SSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPE 189 L FLH + H DLKPQNIL++ +KLADFG A+ S + + Y APE Sbjct: 123 ALQFLHERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPE 182 Query: 190 VLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVAL 249 ++ Q Y VDLWS+G I E +P F S + KI R + L Sbjct: 183 MVCQRQYDARVDLWSMGVILYEALFGQPPFASRSFSELEEKIRS----------NRVIEL 232 Query: 250 PRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQ 301 P + +DLL + L +P++RIS +HP+ Sbjct: 233 P--------------LRPLLSRDCRDLLQRLLERDPSRRISFQDFFAHPWVD 270 >6HXF-B nrPDB Length = 302 Score = 240 bits (612), Expect = 9e-64, Method: Composition-based stats. Identities = 86/311 (27%), Positives = 137/311 (44%), Gaps = 41/311 (13%) Query: 7 CRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLR 66 ++ +E V E+G+GA+GKV+KA++ K G A K + +T E I E+ +L Sbjct: 15 LDPNEVWEIVGELGDGAFGKVYKAKN-KETGALAAAKVI--ETKSEEELEDYIVEIEIL- 70 Query: 67 HLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMM 126 T +HP +V+L + KL ++ E + + G+ I+ + Sbjct: 71 --ATCDHPYIVKLLGAYY-----HDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVC 123 Query: 127 FQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGL-ARIYSFQMALTSVVVTLWY 185 Q+L L+FLHS R++HRDLK N+L+T G I+LADFG+ A+ S + T ++ Sbjct: 124 RQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYW 183 Query: 186 RAPEVLL-----QSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGE 240 APEV++ + Y D+WS+G EM + +P + + L KI Sbjct: 184 MAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKI--------- 234 Query: 241 EDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 +KS P + +D L L NP R SA L HP+ Sbjct: 235 ---------------AKSDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPFV 279 Query: 301 QDLERCKENLD 311 + K + Sbjct: 280 SSITSNKALRE 290 >1PHK-A nrPDB Length = 298 Score = 240 bits (612), Expect = 9e-64, Method: Composition-based stats. Identities = 83/306 (27%), Positives = 126/306 (41%), Gaps = 47/306 (15%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRV-------QTGEEGMPLSTIREVA 63 + YE +G G V + K + A+K + V + + +T++EV Sbjct: 17 ENYEPKEILGRGVSSVVRRCIH-KPTCKEYAVKIIDVTGGGSFSAEEVQELREATLKEVD 75 Query: 64 VLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPGVPTETI 122 +LR + HPN+++L D + T LVF+ + +L YL + + + Sbjct: 76 ILRKVSG--HPNIIQLKD-----TYETNTFFFLVFDLMKKGELFDYL--TEKVTLSEKET 126 Query: 123 KDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVT 182 + +M LL + LH +VHRDLKP+NIL+ IKL DFG + L V T Sbjct: 127 RKIMRALLEVICALHKLNIVHRDLKPENILLDDDMNIKLTDFGFSCQLDPGEKLREVCGT 186 Query: 183 LWYRAPEVLLQS------SYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIG 236 Y APE++ S Y VD+WS G I + P F + L I+ Sbjct: 187 PSYLAPEIIECSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIM---- 242 Query: 237 LPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALS 296 S + Q D + KDL+ + L P KR +A AL+ Sbjct: 243 -------------------SGNYQFGSPEWDDYSDTVKDLVSRFLVVQPQKRYTAEEALA 283 Query: 297 HPYFQD 302 HP+FQ Sbjct: 284 HPFFQQ 289 >2YCR-A nrPDB Length = 323 Score = 239 bits (611), Expect = 9e-64, Method: Composition-based stats. Identities = 75/306 (24%), Positives = 124/306 (40%), Gaps = 47/306 (15%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQT------GEEGMPLSTIREVA 63 +Y +G GA G+V A + K + VA+K + + E L+ E+ Sbjct: 9 RDEYIMSKTLGSGACGEVKLAFERKTCKK-VAIKIISKRKFAIGSAREADPALNVETEIE 67 Query: 64 VLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKV-PEPGVPTETI 122 +L+ L HP ++++ + +V E ++ DKV + T Sbjct: 68 ILKKL---NHPCIIKIKNFFDAE------DYYIVLELMEGG--ELFDKVVGNKRLKEATC 116 Query: 123 KDMMFQLLRGLDFLHSHRVVHRDLKPQNILVT---SSGQIKLADFGLARIYSFQMALTSV 179 K +Q+L + +LH + ++HRDLKP+N+L++ IK+ DFG ++I + ++ Sbjct: 117 KLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTL 176 Query: 180 VVTLWYRAPEVLLQ---SSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIG 236 T Y APEVL+ + Y VD WS+G I P F Sbjct: 177 CGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEH-------------- 222 Query: 237 LPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALS 296 R + S I + ++ E DL+ K L +P R + AL Sbjct: 223 --------RTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALR 274 Query: 297 HPYFQD 302 HP+ QD Sbjct: 275 HPWLQD 280 >1ZWS-A nrPDB Length = 288 Score = 239 bits (609), Expect = 2e-63, Method: Composition-based stats. Identities = 79/314 (25%), Positives = 132/314 (42%), Gaps = 41/314 (13%) Query: 7 CRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVA--LKRVRVQTGEEGMPLSTI-REVA 63 + + Y+ E+G G + V K R+ G + A +K+ + + G+ I REV+ Sbjct: 8 QKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVS 67 Query: 64 VLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQD-LTTYLDKVPEPGVPTETI 122 +LR H NV+ L DV + T + L+ E V L +L + + E Sbjct: 68 ILRQ---VLHHNVITLHDVY-----ENRTDVVLILELVSGGELFDFL--AQKESLSEEEA 117 Query: 123 KDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSG----QIKLADFGLARIYSFQMALTS 178 + Q+L G+++LH+ ++ H DLKP+NI++ IKL DFGLA + + Sbjct: 118 TSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKN 177 Query: 179 VVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLP 238 + T + APE++ D+WS+G I + F G + + L I V Sbjct: 178 IFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITSV---- 233 Query: 239 GEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHP 298 S E+F + EL KD + K L KR++ AL HP Sbjct: 234 -------------------SYDFDEEFFSHTSELAKDFIRKLLVKETRKRLTIQEALRHP 274 Query: 299 YFQDLERCKENLDS 312 + ++ + + Sbjct: 275 WITPVDNQQAMVRR 288 >4KS7-A nrPDB Length = 292 Score = 239 bits (609), Expect = 2e-63, Method: Composition-based stats. Identities = 82/284 (28%), Positives = 138/284 (48%), Gaps = 38/284 (13%) Query: 18 EIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVV 77 +IGEG+ G V AR+ K+ GR VA+K + ++ ++ EV ++R ++H NVV Sbjct: 30 KIGEGSTGIVCLARE-KHSGRQVAVKMMDLR--KQQRRELLFNEVVIMR---DYQHFNVV 83 Query: 78 RLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLH 137 ++ V +L ++ E + T D V + + E I + +L+ L +LH Sbjct: 84 EMYKSYLVGE-----ELWVLMEFLQGGALT--DIVSQVRLNEEQIATVCEAVLQALAYLH 136 Query: 138 SHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQM-ALTSVVVTLWYRAPEVLLQSSY 196 + V+HRD+K +IL+T G++KL+DFG S + S+V T ++ APEV+ +S Y Sbjct: 137 AQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLY 196 Query: 197 ATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHS 256 AT VD+WS+G + EM +P + S V + ++ D Sbjct: 197 ATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRD----------------------- 233 Query: 257 KSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 S P K + + +D L + L +P +R +A L HP+ Sbjct: 234 -SPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFL 276 >3F3Z-A nrPDB Length = 277 Score = 237 bits (606), Expect = 4e-63, Method: Composition-based stats. Identities = 74/305 (24%), Positives = 125/305 (40%), Gaps = 40/305 (13%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLE 69 +Q Y IG G++G+V A R A K + + +E+ +++ L Sbjct: 8 NQYYTLENTIGRGSWGEVKIAVQKGTRIRRAAKKIPKYFVEDVD---RFKQEIEIMKSL- 63 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQL 129 +HPN++RL++ + T + LV E + V + +M + Sbjct: 64 --DHPNIIRLYETF-----EDNTDIYLVMELCTGG-ELFERVVHKRVFRESDAARIMKDV 115 Query: 130 LRGLDFLHSHRVVHRDLKPQNILV---TSSGQIKLADFGLARIYSFQMALTSVVVTLWYR 186 L + + H V HRDLKP+N L + +KL DFGLA + + + V T +Y Sbjct: 116 LSAVAYCHKLNVAHRDLKPENFLFLTDSPDSPLKLIDFGLAARFKPGKMMRTKVGTPYYV 175 Query: 187 APEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRD 246 +P+VL Y D WS G + + P F +D + + KI + E+DW Sbjct: 176 SPQVLEG-LYGPECDEWSAGVMMYVLLCGYPPFSAPTDSEVMLKIREGTFTFPEKDWL-- 232 Query: 247 VALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF-QDLER 305 ++ + L+ + LT +P +RI++ AL H +F + L Sbjct: 233 ---------------------NVSPQAESLIRRLLTKSPKQRITSLQALEHEWFEKQLSS 271 Query: 306 CKENL 310 NL Sbjct: 272 SPRNL 276 >3I6U-A nrPDB Length = 419 Score = 237 bits (605), Expect = 5e-63, Method: Composition-based stats. Identities = 74/306 (24%), Positives = 124/306 (40%), Gaps = 47/306 (15%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQT------GEEGMPLSTIREVA 63 +Y +G GA G+V A + K + VA++ + + E L+ E+ Sbjct: 134 RDEYIMSKTLGSGACGEVKLAFERKTCKK-VAIRIISKRKFAIGSAREADPALNVETEIE 192 Query: 64 VLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKV-PEPGVPTETI 122 +L+ L HP ++++ + +V E ++ DKV + T Sbjct: 193 ILKKL---NHPCIIKIKNFFDAE------DYYIVLELMEGG--ELFDKVVGNKRLKEATC 241 Query: 123 KDMMFQLLRGLDFLHSHRVVHRDLKPQNILVT---SSGQIKLADFGLARIYSFQMALTSV 179 K +Q+L + +LH + ++HRDLKP+N+L++ IK+ DFG ++I + ++ Sbjct: 242 KLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTL 301 Query: 180 VVTLWYRAPEVLLQ---SSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIG 236 T Y APEVL+ + Y VD WS+G I P F Sbjct: 302 CGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEH-------------- 347 Query: 237 LPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALS 296 R + S I + ++ E DL+ K L +P R + AL Sbjct: 348 --------RTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALR 399 Query: 297 HPYFQD 302 HP+ QD Sbjct: 400 HPWLQD 405 >3TXO-A nrPDB Length = 353 Score = 237 bits (605), Expect = 5e-63, Method: Composition-based stats. Identities = 75/317 (23%), Positives = 129/317 (40%), Gaps = 46/317 (14%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQ-TGEEGMPLSTIREVAVLRHLE 69 +E + +G+G++GKV AR +K G A+K ++ ++ T+ E +L Sbjct: 23 DNFEFIRVLGKGSFGKVMLAR-VKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLAR 81 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQ 128 HP + +LF +L V E V+ DL ++ K + + Sbjct: 82 --NHPFLTQLFCCFQTP-----DRLFFVMEFVNGGDLMFHIQKSRR--FDEARARFYAAE 132 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARI-YSFQMALTSVVVTLWYRA 187 ++ L FLH +++RDLK N+L+ G KLADFG+ + + + T Y A Sbjct: 133 IISALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIA 192 Query: 188 PEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDV 247 PE+L + Y VD W++G + EM F ++ D IL+ + Sbjct: 193 PEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVV---------- 242 Query: 248 ALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRI-SAYS-----ALSHPYFQ 301 + T + E +L +T NP R+ S L HP+F+ Sbjct: 243 -----------------YPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFK 285 Query: 302 DLERCKENLDSHLPPSQ 318 +++ + N PP + Sbjct: 286 EIDWAQLNHRQIEPPFR 302 >4JG6-A nrPDB Length = 355 Score = 237 bits (604), Expect = 6e-63, Method: Composition-based stats. Identities = 78/307 (25%), Positives = 125/307 (40%), Gaps = 42/307 (13%) Query: 8 RADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRH 67 + YE +IG G+Y + F A+K + + E+ +L Sbjct: 32 QFTDGYEVKEDIGVGSYSVCKRCIHKATNMEF-AVKIIDKSKRDPTE------EIEIL-- 82 Query: 68 LETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGV-PTETIKDMM 126 L +HPN++ L DV D + +V E + LDK+ ++ Sbjct: 83 LRYGQHPNIITLKDVY-----DDGKYVYVVTELMKGG--ELLDKILRQKFFSEREASAVL 135 Query: 127 FQLLRGLDFLHSHRVVHRDLKPQNIL-VTSSGQ---IKLADFGLARIY-SFQMALTSVVV 181 F + + +++LH+ VVHRDLKP NIL V SG I++ DFG A+ + L + Sbjct: 136 FTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCY 195 Query: 182 TLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEE 241 T + APEVL + Y D+WS+G + M F D D +IL IG Sbjct: 196 TANFVAPEVLERQGYDAACDIWSLGVLLYTMLTGYTPFANGPD-DTPEEILARIG----- 249 Query: 242 DWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQ 301 S + + + KDL+ K L +P +R++A L HP+ Sbjct: 250 --------------SGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIV 295 Query: 302 DLERCKE 308 ++ + Sbjct: 296 HWDQLPQ 302 >5X8I-B nrPDB Length = 346 Score = 236 bits (603), Expect = 8e-63, Method: Composition-based stats. Identities = 94/332 (28%), Positives = 156/332 (46%), Gaps = 45/332 (13%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETF 71 +YE V +GEGA+GKV + D K GGR VA+K V+ + + E+ VL HL T Sbjct: 14 RYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVK---NVDRYCEAARSEIQVLEHLNTT 70 Query: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLR 131 + PN V + + + +VFE + ++ + + I+ M +Q+ + Sbjct: 71 D-PN-STFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICK 128 Query: 132 GLDFLHSHRVVHRDLKPQNILVTS-------------------SGQIKLADFGLARIYSF 172 ++FLHS+++ H DLKP+NIL + IK+ DFG A Sbjct: 129 SVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATY--D 186 Query: 173 QMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKIL 232 +++V T YRAPEV+L ++ P D+WS+GCI E + +F + L + Sbjct: 187 DEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMME 246 Query: 233 DVIGLPGEEDWPRDVALPRQAFH---------------SKSAQPIEKFVTDID---ELGK 274 ++G P + + + H S++ +P+++F+ D E Sbjct: 247 RILG-PLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQDVEHERLF 305 Query: 275 DLLLKCLTFNPAKRISAYSALSHPYFQDLERC 306 DL+ K L ++PAKRI+ AL HP+F L++ Sbjct: 306 DLIQKMLEYDPAKRITLREALKHPFFDLLKKS 337 >2JDO-A nrPDB Length = 342 Score = 236 bits (602), Expect = 1e-62, Method: Composition-based stats. Identities = 78/324 (24%), Positives = 128/324 (39%), Gaps = 46/324 (14%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 ++ + +G+G +GKV R+ K GR+ A+K +R + ++ V R L+ Sbjct: 10 NDFDYLKLLGKGTFGKVILVRE-KATGRYYAMKILRKEVIIAKDEVAHT--VTESRVLQN 66 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQD-LTTYLDKVPEPGVPTETIKDMMFQL 129 HP + L +L V E+ + L +L + E E + ++ Sbjct: 67 TRHPFLTALKYAFQT-----HDRLCFVMEYANGGELFFHLSR--ERVFTEERARFYGAEI 119 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARI-YSFQMALTSVVVTLWYRAP 188 + L++LHS VV+RD+K +N+++ G IK+ DFGL + S + + T Y AP Sbjct: 120 VSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAP 179 Query: 189 EVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA 248 EVL + Y VD W +G + EM + F IL Sbjct: 180 EVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILM--------------- 224 Query: 249 LPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRI-----SAYSALSHPYFQDL 303 +F + K LL L +P +R+ A + H +F + Sbjct: 225 ------------EEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSI 272 Query: 304 ERCKENLDSHLPPS--QNTSELNT 325 LPP Q TSE++T Sbjct: 273 NWQDVVQKKLLPPFKPQVTSEVDT 296 >4QMW-A nrPDB Length = 310 Score = 236 bits (602), Expect = 1e-62, Method: Composition-based stats. Identities = 75/293 (25%), Positives = 145/293 (49%), Gaps = 39/293 (13%) Query: 9 ADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHL 68 ++ + + +IG+G++G+VFK D + + VA+K + ++ E +E+ VL Sbjct: 27 PEELFTKLEKIGKGSFGEVFKGIDNRT-QKVVAIKIIDLEEAE-DEIEDIQQEITVLSQC 84 Query: 69 ETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQ 128 ++ P V + + ++TKL ++ E++ + LD + + I ++ + Sbjct: 85 DS---PYVTKYYGSYL-----KDTKLWIIMEYLGGG--SALDLLEPGPLDETQIATILRE 134 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLA-RIYSFQMALTSVVVTLWYRA 187 +L+GLD+LHS + +HRD+K N+L++ G++KLADFG+A ++ Q+ + V T ++ A Sbjct: 135 ILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMA 194 Query: 188 PEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDV 247 PEV+ QS+Y + D+WS+G E+ R +P S++ + K+L +I + Sbjct: 195 PEVIKQSAYDSKADIWSLGITAIELARGEPP---HSELHPM-KVLFLIPKNNPPTLEGNY 250 Query: 248 ALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 + P K+ + CL P+ R +A L H + Sbjct: 251 SKP----------------------LKEFVEACLNKEPSFRPTAKELLKHKFI 281 >2XIK-A nrPDB Length = 294 Score = 236 bits (602), Expect = 1e-62, Method: Composition-based stats. Identities = 77/298 (25%), Positives = 139/298 (46%), Gaps = 39/298 (13%) Query: 9 ADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHL 68 ++ + + IG+G++G+V+K D + VA+K + ++ E +E+ VL Sbjct: 17 PEELFTKLDRIGKGSFGEVYKGID-NHTKEVVAIKIIDLEEAE-DEIEDIQQEITVLSQC 74 Query: 69 ETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQ 128 ++ P + R F S TKL ++ E++ + LD + + I ++ + Sbjct: 75 DS---PYITRYFGSYLKS-----TKLWIIMEYLGGG--SALDLLKPGPLEETYIATILRE 124 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLA-RIYSFQMALTSVVVTLWYRA 187 +L+GLD+LHS R +HRD+K N+L++ G +KLADFG+A ++ Q+ + V T ++ A Sbjct: 125 ILKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMA 184 Query: 188 PEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDV 247 PEV+ QS+Y D+WS+G E+ + +P + L I P++ Sbjct: 185 PEVIKQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLI------------PKNS 232 Query: 248 ALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLER 305 + HSK K+ + CL +P R +A L H + + Sbjct: 233 PPTLEGQHSKP--------------FKEFVEACLNKDPRFRPTAKELLKHKFITRYTK 276 >4RED-A nrPDB Length = 351 Score = 235 bits (601), Expect = 1e-62, Method: Composition-based stats. Identities = 75/293 (25%), Positives = 122/293 (41%), Gaps = 39/293 (13%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETF 71 Y +G G +GKV + + G VA+K + Q + IR +++L+ F Sbjct: 15 HYILGDTLGVGTFGKVKVGKH-ELTGHAVAVKILNRQKIRSLDVVGKIR--REIQNLKLF 71 Query: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQD-LTTYLDKVPEPGVPTETIKDMMFQLL 130 HP++++L+ V + + + +V E+V L Y+ + + + + Q+L Sbjct: 72 RHPHIIKLYQVISTP-----SDIFMVMEYVSGGELFDYI--CKNGRLDEKESRRLFQQIL 124 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEV 190 G+D+ H H VVHRDLKP+N+L+ + K+ADFGL+ + S L + + Y APEV Sbjct: 125 SGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEV 184 Query: 191 LLQSSY-ATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVAL 249 + Y VD+WS G I + F KI D I + P ++ Sbjct: 185 ISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVIS- 243 Query: 250 PRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQD 302 LL L +P KR S H +F+ Sbjct: 244 --------------------------LLKHMLQVDPMKRASIKDIREHEWFKQ 270 >4CFH-A nrPDB Length = 493 Score = 235 bits (601), Expect = 1e-62, Method: Composition-based stats. Identities = 74/293 (25%), Positives = 122/293 (41%), Gaps = 39/293 (13%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETF 71 Y +G G +GKV + G + VA+K + Q + IR +++L+ F Sbjct: 34 HYILGDTLGVGTFGKVKVGKHELTGHK-VAVKILNRQKIRSLDVVGKIR--REIQNLKLF 90 Query: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQD-LTTYLDKVPEPGVPTETIKDMMFQLL 130 HP++++L+ V + + + +V E+V L Y+ + + + + Q+L Sbjct: 91 RHPHIIKLYQVISTP-----SDIFMVMEYVSGGELFDYI--CKNGRLDEKESRRLFQQIL 143 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEV 190 G+D+ H H VVHRDLKP+N+L+ + K+ADFGL+ + S L + + Y APEV Sbjct: 144 SGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEV 203 Query: 191 LLQSSY-ATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVAL 249 + Y VD+WS G I + F KI D I + P ++ Sbjct: 204 ISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVIS- 262 Query: 250 PRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQD 302 LL L +P KR + H +F+ Sbjct: 263 --------------------------LLKHMLQVDPMKRATIKDIREHEWFKQ 289 >5WAX-A nrPDB Length = 310 Score = 235 bits (601), Expect = 1e-62, Method: Composition-based stats. Identities = 79/294 (26%), Positives = 122/294 (41%), Gaps = 39/294 (13%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 +YE V +IG G +G R+ + G+ VA+K + E + + RE+ R L Sbjct: 11 DRYELVRDIGSGNFGVARLMRNRAD-GQLVAVKYIERG---EKIDENVQREIINHRSLR- 65 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPG-VPTETIKDMMFQL 129 HPN++R +V T L +V E+ +++ G + + QL Sbjct: 66 --HPNIIRFKEVILTP-----THLAIVMEYASGG--ELFERICNAGRFSEDEARFFFQQL 116 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSG--QIKLADFGLARIYSFQMALTSVVVTLWYRA 187 + G+ + HS +V HRDLK +N L+ S ++K+ DFG ++ S V T Y A Sbjct: 117 ISGVSYCHSMQVCHRDLKLENTLLDGSTAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIA 176 Query: 188 PEVLLQSSYATPV-DLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRD 246 PEVLL+ Y V D+WS G M F + K + I L + P Sbjct: 177 PEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRI-LGVQYSIPDY 235 Query: 247 VALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 V I +DL+ + NPA RI+ +HP+F Sbjct: 236 V--------------------HISPECQDLISRIFVANPATRITIPEIRNHPWF 269 >4PDS-A nrPDB Length = 347 Score = 235 bits (599), Expect = 3e-62, Method: Composition-based stats. Identities = 75/308 (24%), Positives = 130/308 (42%), Gaps = 52/308 (16%) Query: 11 QQYECV-AEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLE 69 + + + +G+GA+ V KA + + G+ ++K + + G RE+ VL+ L Sbjct: 30 KDFSIIDEVVGQGAFATVKKAIE-RTTGKTFSVKIISKRKVI-GNMDGVTRELEVLQKL- 86 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPGVPTETIKDMMFQ 128 HP +VRL + + +V E V DL ++ V + +++ Q Sbjct: 87 --NHPRIVRLKGFYEDTES-----YYMVMEFVSGGDLMDFV--AAHGAVGEDAGREISRQ 137 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQ--IKLADFGLARIYSFQMALTSVVVTLWYR 186 +L + ++HS + HRDLKP NIL+ +K+ FGLA++ + + TL Y Sbjct: 138 ILTAIKYIHSMGISHRDLKPDNILIEQDDPVLVKITAFGLAKVQGNGSFMKTFCGTLAYV 197 Query: 187 APEVLLQS-------------SYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILD 233 APEV+ Y++ VD+WS+GC+ + F GS+ +I Sbjct: 198 APEVIRGKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGR 257 Query: 234 VIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYS 293 S P++ F I E +D + L +P R +A Sbjct: 258 G---------------------SYHEGPLKDF--RISEEARDFIDSLLQVDPNNRSTAAK 294 Query: 294 ALSHPYFQ 301 AL+HP+ + Sbjct: 295 ALNHPWIK 302 >3HDN-A nrPDB Length = 373 Score = 234 bits (598), Expect = 3e-62, Method: Composition-based stats. Identities = 78/313 (24%), Positives = 125/313 (39%), Gaps = 44/313 (14%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRV-RVQTGEEGMPLSTIREVAVLRHLE 69 + + IG+G++GKV AR K F A+K + + ++ + E VL L+ Sbjct: 38 SDFHFLKVIGKGSFGKVLLARH-KAEEVFYAVKVLQKKAILKKKEEKHIMSERNVL--LK 94 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQD-LTTYLDKVPEPGVPTETIKDMMFQ 128 +HP +V L + KL V ++++ L +L + E + + Sbjct: 95 NVKHPFLVGLHFSFQTA-----DKLYFVLDYINGGELFYHLQR--ERCFLEPRARFYAAE 147 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARI-YSFQMALTSVVVTLWYRA 187 + L +LHS +V+RDLKP+NIL+ S G I L DFGL + ++ T Y A Sbjct: 148 IASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLA 207 Query: 188 PEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDV 247 PEVL + Y VD W +G + EM P F + + IL+ Sbjct: 208 PEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILN-------------- 253 Query: 248 ALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAY----SALSHPYFQDL 303 +P+ + +I + LL L + KR+ A SH +F + Sbjct: 254 ------------KPL-QLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLI 300 Query: 304 ERCKENLDSHLPP 316 PP Sbjct: 301 NWDDLINKKITPP 313 >2X4F-A nrPDB Length = 373 Score = 234 bits (598), Expect = 3e-62, Method: Composition-based stats. Identities = 77/290 (26%), Positives = 125/290 (43%), Gaps = 40/290 (13%) Query: 17 AEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNV 76 +G G +G+V K + G + A K ++ + ++ E++V+ L +H N+ Sbjct: 95 EILGGGRFGQVHKCEETATGLKLAA-KIIKTRGMKD--KEEVKNEISVMNQL---DHANL 148 Query: 77 VRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPG--VPTETIKDMMFQLLRGLD 134 ++L+D + + + LV E+VD D++ + + M Q+ G+ Sbjct: 149 IQLYDAF-----ESKNDIVLVMEYVDGG--ELFDRIIDESYNLTELDTILFMKQICEGIR 201 Query: 135 FLHSHRVVHRDLKPQNILVTSS--GQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLL 192 +H ++H DLKP+NIL + QIK+ DFGLAR Y + L T + APEV+ Sbjct: 202 HMHQMYILHLDLKPENILCVNRDAKQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVN 261 Query: 193 QSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQ 252 + P D+WSVG I + F G +D + L IL Sbjct: 262 YDFVSFPTDMWSVGVIAYMLLSGLSPFLGDNDAETLNNILAC------------------ 303 Query: 253 AFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQD 302 ++ DI E K+ + K L + RISA AL HP+ D Sbjct: 304 -----RWDLEDEEFQDISEEAKEFISKLLIKEKSWRISASEALKHPWLSD 348 >4CFF-A nrPDB Length = 571 Score = 234 bits (598), Expect = 4e-62, Method: Composition-based stats. Identities = 73/294 (24%), Positives = 116/294 (39%), Gaps = 41/294 (13%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEE-GMPLSTIREVAVLRHLET 70 Y +G G +GKV G + VA+K + Q + RE+ +L+ Sbjct: 34 HYVLGDTLGVGTFGKVKIGEHQLTGHK-VAVKILNRQKIRSLDVVGKIKREIQ---NLKL 89 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQD-LTTYLDKVPEPGVPTETIKDMMFQL 129 F HP++++L+ V + T +V E+V L Y+ V + + Q+ Sbjct: 90 FRHPHIIKLYQVISTP-----TDFFMVMEYVSGGELFDYI--CKHGRVEEMEARRLFQQI 142 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPE 189 L +D+ H H VVHRDLKP+N+L+ + K+ADFGL+ + S L + + Y APE Sbjct: 143 LSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPE 202 Query: 190 VLLQSSY-ATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA 248 V+ Y VD+WS G I + F KI + E Sbjct: 203 VISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEY------- 255 Query: 249 LPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQD 302 ++ LL+ L +P KR + H +F+ Sbjct: 256 --------------------LNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQ 289 >3UTO-A nrPDB Length = 573 Score = 234 bits (597), Expect = 5e-62, Method: Composition-based stats. Identities = 76/317 (23%), Positives = 129/317 (40%), Gaps = 38/317 (11%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 Y+ E+G GA+G V + + G F A + T E + +E+ + L Sbjct: 157 DHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVM---TPHESDKETVRKEIQTMSVLR- 212 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130 HP +V L D + + ++ +++E + + + + M Q+ Sbjct: 213 --HPTLVNLHDAF-----EDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMRQVC 265 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTS--SGQIKLADFGLARIYSFQMALTSVVVTLWYRAP 188 +GL +H + VH DLKP+NI+ T+ S ++KL DFGL + ++ T + AP Sbjct: 266 KGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTTGTAEFAAP 325 Query: 189 EVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA 248 EV D+WSVG + + F G +D + L + DW D Sbjct: 326 EVAEGKPVGYYTDMWSVGVLSYILLSGLSPFGGENDDETLRNVKSC-------DWNMD-- 376 Query: 249 LPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKE 308 + + I E GKD + K L +P R++ + AL HP+ Sbjct: 377 --------------DSAFSGISEDGKDFIRKLLLADPNTRMTIHQALEHPWLT--PGNAP 420 Query: 309 NLDSHLPPSQNTSELNT 325 DS +P S+ T ++ Sbjct: 421 GRDSQIPSSRYTKIRDS 437 >4FZF-B nrPDB Length = 283 Score = 234 bits (597), Expect = 5e-62, Method: Composition-based stats. Identities = 71/297 (23%), Positives = 135/297 (45%), Gaps = 39/297 (13%) Query: 5 GLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAV 64 + ++ + + IG+G++G+VFK D + + VA+K + ++ E +E+ V Sbjct: 2 AMADPEELFTKLERIGKGSFGEVFKGIDNRT-QQVVAIKIIDLEEAE-DEIEDIQQEITV 59 Query: 65 LRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKD 124 L ++ V + + + +KL ++ E++ + LD + I Sbjct: 60 LSQCDSS---YVTKYYGSYL-----KGSKLWIIMEYLGGG--SALDLLRAGPFDEFQIAT 109 Query: 125 MMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLA-RIYSFQMALTSVVVTL 183 M+ ++L+GLD+LHS + +HRD+K N+L++ G +KLA FG+A ++ Q+ + V T Sbjct: 110 MLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLAAFGVAGQLTDTQIKRNTFVGTP 169 Query: 184 WYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDW 243 ++ APEV+ QS+Y + D+WS+G E+ + +P + L I Sbjct: 170 FWMAPEVIQQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLI------------ 217 Query: 244 PRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 V D + K+ + CL +P+ R +A L H + Sbjct: 218 --------------PKNNPPTLVGDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFI 260 >5EZV-A nrPDB Length = 560 Score = 233 bits (595), Expect = 7e-62, Method: Composition-based stats. Identities = 73/294 (24%), Positives = 116/294 (39%), Gaps = 41/294 (13%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEE-GMPLSTIREVAVLRHLET 70 Y +G G +GKV G + VA+K + Q + RE+ +L+ Sbjct: 29 HYVLGDTLGVGTFGKVKIGEHQLTGHK-VAVKILNRQKIRSLDVVGKIKREIQ---NLKL 84 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQD-LTTYLDKVPEPGVPTETIKDMMFQL 129 F HP++++L+ V + T +V E+V L Y+ V + + Q+ Sbjct: 85 FRHPHIIKLYQVISTP-----TDFFMVMEYVSGGELFDYI--CKHGRVEEMEARRLFQQI 137 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPE 189 L +D+ H H VVHRDLKP+N+L+ + K+ADFGL+ + S L + + Y APE Sbjct: 138 LSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPE 197 Query: 190 VLLQSSY-ATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA 248 V+ Y VD+WS G I + F KI + E Sbjct: 198 VISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEY------- 250 Query: 249 LPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQD 302 ++ LL+ L +P KR + H +F+ Sbjct: 251 --------------------LNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQ 284 >3IS5-A nrPDB Length = 285 Score = 232 bits (593), Expect = 1e-61, Method: Composition-based stats. Identities = 74/301 (24%), Positives = 122/301 (40%), Gaps = 45/301 (14%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLE 69 D + ++G GA+G V + +G V +K + + M E+ VL+ L Sbjct: 21 DDLFIFKRKLGSGAFGDVHLVEERSSGLERV-IKTINKDRSQVPM-EQIEAEIEVLKSL- 77 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKV-----PEPGVPTETIKD 124 +HPN++++F+V + + +V E + L+++ + + + Sbjct: 78 --DHPNIIKIFEVF-----EDYHNMYIVMETCEGG--ELLERIVSAQARGKALSEGYVAE 128 Query: 125 MMFQLLRGLDFLHSHRVVHRDLKPQNILVTS---SGQIKLADFGLARIYSFQMALTSVVV 181 +M Q++ L + HS VVH+DLKP+NIL IK+ DFGLA ++ T+ Sbjct: 129 LMKQMMNALAYFHSQHVVHKDLKPENILFQDTSPHSPIKIIDFGLAELFKSDEHSTNAAG 188 Query: 182 TLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEE 241 T Y APEV D+WS G + + F G+S + K Sbjct: 189 TALYMAPEVFK-RDVTFKCDIWSAGVVMYFLLTGCLPFTGTSLEEVQQK----------- 236 Query: 242 DWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQ 301 P A + P DLL + LT +P +R SA L H +F+ Sbjct: 237 ---ATYKEPNYAVECRPLTP----------QAVDLLKQMLTKDPERRPSAAQVLHHEWFK 283 Query: 302 D 302 Sbjct: 284 Q 284 >5KCV-A nrPDB Length = 460 Score = 232 bits (593), Expect = 1e-61, Method: Composition-based stats. Identities = 72/315 (22%), Positives = 122/315 (38%), Gaps = 47/315 (14%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQ-TGEEGMPLSTIREVAVLRHLE 69 ++E + +G+G +GKV ++ K GR+ A+K ++ + + T+ E VL++ Sbjct: 162 NEFEYLKLLGKGTFGKVILVKE-KATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQN-- 218 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQD-LTTYLDKVPEPGVPTETIKDMMFQ 128 HP + L +L V E+ + L +L + E + + + Sbjct: 219 -SRHPFLTALKYSFQT-----HDRLCFVMEYANGGELFFHLSR--ERVFSEDRARFYGAE 270 Query: 129 LLRGLDFLHS-HRVVHRDLKPQNILVTSSGQIKLADFGLARI-YSFQMALTSVVVTLWYR 186 ++ LD+LHS VV+RDLK +N+++ G IK+ DFGL + + + T Y Sbjct: 271 IVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYL 330 Query: 187 APEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRD 246 APEVL + Y VD W +G + EM + F IL Sbjct: 331 APEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILM------------- 377 Query: 247 VALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRI-----SAYSALSHPYFQ 301 +F + K LL L +P +R+ A + H +F Sbjct: 378 --------------EEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFA 423 Query: 302 DLERCKENLDSHLPP 316 + PP Sbjct: 424 GIVWQHVYEKKLSPP 438 >5LOH-A nrPDB Length = 341 Score = 232 bits (593), Expect = 1e-61, Method: Composition-based stats. Identities = 75/315 (23%), Positives = 123/315 (39%), Gaps = 48/315 (15%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTG-EEGMPLSTIREVAVLRHLE 69 +++ V I GA+GKV+ + GG+ A+K V+ + M E L + Sbjct: 36 EEFSIVKPISRGAFGKVYLGQ---KGGKLYAVKVVKKADMINKNMTHQVQAERDALALSK 92 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPGVPTETIKDMMFQ 128 + P +V L+ + LV E++ D+ + L E + + Sbjct: 93 S---PFIVHLY-----YSLQSANNVYLVMEYLIGGDVKSLLHIYG--YFDEEMAVKYISE 142 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARI-------YSFQMALTSVVV 181 + LD+LH H ++HRDLKP N+L+++ G IKL DFGL+++ + + Sbjct: 143 VALALDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILTTRTFCG 202 Query: 182 TLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEE 241 T Y APE+LL ++ VD W++G E P F + IL Sbjct: 203 TPDYLAPELLLGRAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNIL--------- 253 Query: 242 DWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQ 301 K P + + + + + LT + KR HP F Sbjct: 254 ---------------KRDIPWPEGEEKLSDNAQSAVEILLTIDDTKRAGMKELKRHPLFS 298 Query: 302 DLERCKENLDSHLPP 316 D++ ENL P Sbjct: 299 DVDW--ENLQHQTMP 311 >1KOA-A nrPDB Length = 491 Score = 232 bits (591), Expect = 2e-61, Method: Composition-based stats. Identities = 76/317 (23%), Positives = 129/317 (40%), Gaps = 38/317 (11%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 Y+ E+G GA+G V + + G F A + T E + +E+ + L Sbjct: 51 DHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVM---TPHESDKETVRKEIQTMSVLR- 106 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130 HP +V L D + + ++ +++E + + + + M Q+ Sbjct: 107 --HPTLVNLHDAF-----EDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMRQVC 159 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTS--SGQIKLADFGLARIYSFQMALTSVVVTLWYRAP 188 +GL +H + VH DLKP+NI+ T+ S ++KL DFGL + ++ T + AP Sbjct: 160 KGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTTGTAEFAAP 219 Query: 189 EVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA 248 EV D+WSVG + + F G +D + L + DW D Sbjct: 220 EVAEGKPVGYYTDMWSVGVLSYILLSGLSPFGGENDDETLRNVKSC-------DWNMD-- 270 Query: 249 LPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKE 308 + + I E GKD + K L +P R++ + AL HP+ Sbjct: 271 --------------DSAFSGISEDGKDFIRKLLLADPNTRMTIHQALEHPWLT--PGNAP 314 Query: 309 NLDSHLPPSQNTSELNT 325 DS +P S+ T ++ Sbjct: 315 GRDSQIPSSRYTKIRDS 331 >5J5T-A nrPDB Length = 370 Score = 232 bits (591), Expect = 2e-61, Method: Composition-based stats. Identities = 77/298 (25%), Positives = 127/298 (42%), Gaps = 38/298 (12%) Query: 9 ADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHL 68 + + +E + IG G YG V+KAR++ N G A+K ++++ GE+ + +E+ +++ Sbjct: 2 SQEDFELIQRIGSGTYGDVYKARNV-NTGELAAIKVIKLEPGEDFAVVQ--QEIIMMKDC 58 Query: 69 ETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQ 128 + HPN+V F R KL + E + V P + I + + Sbjct: 59 K---HPNIVAYFGSYL-----RRDKLWICMEFCGGGSLQDIYHVTGP-LSELQIAYVSRE 109 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQM-ALTSVVVTLWYRA 187 L+GL +LHS +HRD+K NIL+T +G +KLADFG++ + + + + T ++ A Sbjct: 110 TLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKAFIGTPYWMA 169 Query: 188 PEVL---LQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWP 244 PEV + Y DLW+VG E+ +P + L + P Sbjct: 170 PEVAAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQP------ 223 Query: 245 RDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQD 302 P K + LT NP KR +A L HP+ Sbjct: 224 ----------------PKLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQ 265 >4D28-A nrPDB Length = 446 Score = 231 bits (590), Expect = 3e-61, Method: Composition-based stats. Identities = 80/300 (26%), Positives = 124/300 (41%), Gaps = 42/300 (14%) Query: 7 CRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQT-GEEGMPLSTIREVAVL 65 R +YE IGEG + KV AR+ G VA+K + T + M RE++++ Sbjct: 5 MRRVGKYEVGRTIGEGTFAKVKFARNTDTGDN-VAIKIMAKSTILKNRMVDQIKREISIM 63 Query: 66 RHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPG-VPTETIKD 124 + HPN+VRL++V ++K+ +V E V D++ G + + + Sbjct: 64 K---IVRHPNIVRLYEVLA-----SKSKIYIVLEFVTGG--ELFDRIVHKGRLKEDESRK 113 Query: 125 MMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMA-LTSVVVTL 183 QL+ + HS V HRDLKP+N+L+ ++G +K++DFGL+ + + L T Sbjct: 114 YFQQLVDAVAHCHSKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLNDTCGTP 173 Query: 184 WYRAPEVLLQSSYA-TPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEED 242 Y APEVL Y + D+WS G I + F + KI E D Sbjct: 174 NYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKI-----NAAEFD 228 Query: 243 WPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQD 302 P K L+ + L NP RI P+F+ Sbjct: 229 CP----------------------PWFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRK 266 >3MV5-A nrPDB Length = 342 Score = 231 bits (589), Expect = 3e-61, Method: Composition-based stats. Identities = 72/315 (22%), Positives = 122/315 (38%), Gaps = 47/315 (14%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQ-TGEEGMPLSTIREVAVLRHLE 69 ++E + +G+G +GKV ++ K GR+ A+K ++ + + T+ E VL++ Sbjct: 10 NEFEYLKLLGKGTFGKVILVKE-KATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQN-- 66 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQD-LTTYLDKVPEPGVPTETIKDMMFQ 128 HP + L +L V E+ + L +L + E + + + Sbjct: 67 -SRHPFLTALKYSFQT-----HDRLCFVMEYANGGELFFHLSR--ERVFSEDRARFYGAE 118 Query: 129 LLRGLDFLHS-HRVVHRDLKPQNILVTSSGQIKLADFGLARI-YSFQMALTSVVVTLWYR 186 ++ LD+LHS VV+RDLK +N+++ G IK+ DFGL + + + T Y Sbjct: 119 IVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYL 178 Query: 187 APEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRD 246 APEVL + Y VD W +G + EM + F IL Sbjct: 179 APEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILM------------- 225 Query: 247 VALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRI-----SAYSALSHPYFQ 301 +F + K LL L +P +R+ A + H +F Sbjct: 226 --------------EEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFA 271 Query: 302 DLERCKENLDSHLPP 316 + PP Sbjct: 272 GIVWQHVYEKKLSPP 286 >1KOB-A nrPDB Length = 387 Score = 231 bits (589), Expect = 4e-61, Method: Composition-based stats. Identities = 70/311 (22%), Positives = 126/311 (40%), Gaps = 39/311 (12%) Query: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 Y+ + E+G GA+G V + + G FVA K + T + E++++ L Sbjct: 53 YDILEELGSGAFGVVHRCVEKATGRVFVA-KFIN--TPYPLDKYTVKNEISIMNQL---H 106 Query: 73 HPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRG 132 HP ++ L D + + ++ L+ E + + + + + M Q G Sbjct: 107 HPKLINLHDAF-----EDKYEMVLILEFLSGGELFDRIAAEDYKMSEAEVINYMRQACEG 161 Query: 133 LDFLHSHRVVHRDLKPQNILVTSSG--QIKLADFGLARIYSFQMALTSVVVTLWYRAPEV 190 L +H H +VH D+KP+NI+ + +K+ DFGLA + + T + APE+ Sbjct: 162 LKHMHEHSIVHLDIKPENIMCETKKASSVKIIDFGLATKLNPDEIVKVTTATAEFAAPEI 221 Query: 191 LLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALP 250 + + D+W++G + + F G D++ L + DW D Sbjct: 222 VDREPVGFYTDMWAIGVLGYVLLSGLSPFAGEDDLETLQNVKRC-------DWEFD---- 270 Query: 251 RQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENL 310 E + + KD + L P KR++ + AL HP+ + NL Sbjct: 271 ------------EDAFSSVSPEAKDFIKNLLQKEPRKRLTVHDALEHPWLK---GDHSNL 315 Query: 311 DSHLPPSQNTS 321 S +P S+ Sbjct: 316 TSRIPSSRYNK 326 >5F9E-A nrPDB Length = 353 Score = 230 bits (588), Expect = 4e-61, Method: Composition-based stats. Identities = 81/312 (25%), Positives = 130/312 (41%), Gaps = 41/312 (13%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQT-GEEGMPLSTIREVAVLRHLE 69 + +E +G+G++GKVF A + K +F A+K ++ + T+ E VL Sbjct: 19 EDFELHKMLGKGSFGKVFLA-EFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSL-- 75 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQ 128 +EHP + +F + L V E+++ DL ++ + + Sbjct: 76 AWEHPFLTHMF-----CTFQTKENLFFVMEYLNGGDLMYHIQSCHK--FDLSRATFYAAE 128 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTS-VVVTLWYRA 187 ++ GL FLHS +V+RDLK NIL+ G IK+ADFG+ + A T+ T Y A Sbjct: 129 IILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNEFCGTPDYIA 188 Query: 188 PEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDV 247 PE+LL Y VD WS G + EM + F G + + I D P Sbjct: 189 PEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIR--------MDNPF-- 238 Query: 248 ALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAY-SALSHPYFQDLERC 306 + +++ KDLL+K P KR+ HP F+++ Sbjct: 239 -----------------YPRWLEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFREINWE 281 Query: 307 KENLDSHLPPSQ 318 + PP + Sbjct: 282 ELERKEIDPPFR 293 >4JXF-A nrPDB Length = 266 Score = 230 bits (588), Expect = 5e-61, Method: Composition-based stats. Identities = 73/293 (24%), Positives = 133/293 (45%), Gaps = 40/293 (13%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEE-GMPLSTIREVAVLRHLE 69 + ++ +G+G++ V++A + G VA+K + + + GM EV + L+ Sbjct: 7 EDFKVGNLLGKGSFAGVYRAESIHTGLE-VAIKMIDKKAMYKAGMVQRVQNEVKIHCQLK 65 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPGVPTETIKDMMFQ 128 HP+++ L++ S + LV E + ++ YL +P + M Q Sbjct: 66 ---HPSILELYNYFEDS-----NYVYLVLEMCHNGEMNRYLKNRVKP-FSENEARHFMHQ 116 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYS-FQMALTSVVVTLWYRA 187 ++ G+ +LHSH ++HRDL N+L+T + IK+ADFGLA ++ T Y + Sbjct: 117 IITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYIS 176 Query: 188 PEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDV 247 PE+ +S++ D+WS+GC+F + +P F + + L K++ Sbjct: 177 PEIATRSAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVV--------------- 221 Query: 248 ALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 + + + KDL+ + L NPA R+S S L HP+ Sbjct: 222 ------------LADYEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFM 262 >6O6Q-A nrPDB Length = 335 Score = 230 bits (587), Expect = 6e-61, Method: Composition-based stats. Identities = 76/308 (24%), Positives = 148/308 (48%), Gaps = 27/308 (8%) Query: 9 ADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHL 68 + YE + ++G G Y +VF DL+ + V +K ++ RE+++L++L Sbjct: 39 PQENYEILRKLGRGKYSEVFLGIDLEKREKVV-IKVLK-----PVKRKKIKREISILKNL 92 Query: 69 ETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQ 128 + PN++ + DV ++ L+FEH++ + P I+ M++ Sbjct: 93 --VDGPNIIAMLDVVREPQSKTPG---LIFEHINN----IDFRSLYPTFTDYDIRFYMYE 143 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQ-IKLADFGLARIYSFQMALTSVVVTLWYRA 187 LL+ LD+ HS ++HRD+KP N+++ + ++L D+GLA Y V + +++ Sbjct: 144 LLKALDYSHSMGIMHRDVKPHNVMIDHDKKLLRLIDWGLAEYYHPGTEYNVRVASRYFKG 203 Query: 188 PEVLL-QSSYATPVDLWSVGCIFAEM-FRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPR 245 PE+L+ Y +D+WS GC+ A M F ++P F G S+ DQL +I+ V+G + + Sbjct: 204 PELLVDYRLYDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQLVQIVRVLGSKNFKKYLE 263 Query: 246 DVALPRQAFHSKSAQPIEKFVTD---------IDELGKDLLLKCLTFNPAKRISAYSALS 296 + + ++ + + DL+ + L ++ +R++A A+ Sbjct: 264 KYNISLGEEYEDIGYYNKRQWVRFMNENNKDLVSQEFLDLIDRLLRYDHQERLTAKEAMK 323 Query: 297 HPYFQDLE 304 H YF + Sbjct: 324 HAYFDPIR 331 >3RAW-A nrPDB Length = 381 Score = 230 bits (587), Expect = 6e-61, Method: Composition-based stats. Identities = 90/344 (26%), Positives = 153/344 (44%), Gaps = 49/344 (14%) Query: 2 EKDG--LCRA----DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMP 55 +K+G +CR ++YE V +GEG +GKV + D G VALK +R Sbjct: 36 DKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGK---YR 92 Query: 56 LSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEP 115 + E+ VL+ ++ + N + V + + + FE + ++ +L + Sbjct: 93 EAARLEINVLKKIKEKDKEN--KFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQ 150 Query: 116 GVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTS-------------------S 156 P ++ M +QL L FLH +++ H DLKP+NIL + + Sbjct: 151 PYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKN 210 Query: 157 GQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRK 216 I++ADFG A T++V T YR PEV+L+ +A P D+WS+GCI E +R Sbjct: 211 TSIRVADFGSATFDHEHH--TTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGF 268 Query: 217 PLFRGSSDVDQLGKILDVIGLPGEEDWPR--------------DVALPRQAFHSKSAQPI 262 LF+ + + L + ++G R D + ++ +P+ Sbjct: 269 TLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPL 328 Query: 263 EKFVTDIDELGK---DLLLKCLTFNPAKRISAYSALSHPYFQDL 303 + ++ DL+ + L F+PA+RI+ AL HP+F L Sbjct: 329 KSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGL 372 >2HW6-A nrPDB Length = 307 Score = 230 bits (587), Expect = 7e-61, Method: Composition-based stats. Identities = 82/312 (26%), Positives = 126/312 (40%), Gaps = 38/312 (12%) Query: 8 RADQQYECVAEI-GEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLR 66 + + Y+ +E+ GEGAY KV A L+NG A+K + Q G REV L Sbjct: 9 KFEDMYKLTSELLGEGAYAKVQGAVSLQNGKE-YAVKIIEKQAGHS--RSRVFREVETLY 65 Query: 67 HLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPGVPTETIKDM 125 + + N++ L + + +T+ LVFE + + ++ K + Sbjct: 66 QCQGNK--NILELIEFF-----EDDTRFYLVFEKLQGGSILAHIQKQKH--FNEREASRV 116 Query: 126 MFQLLRGLDFLHSHRVVHRDLKPQNILVTSS---GQIKLADFGLARIYSFQMA------- 175 + + LDFLH+ + HRDLKP+NIL S +K+ DF L + Sbjct: 117 VRDVAAALDFLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTP 176 Query: 176 -LTSVVVTLWYRAPEVL-----LQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLG 229 LT+ + Y APEV+ + Y DLWS+G + M P F G D Sbjct: 177 ELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGAD--- 233 Query: 230 KILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRI 289 G E ++ + +K I KDL+ K L + +R+ Sbjct: 234 -----CGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRL 288 Query: 290 SAYSALSHPYFQ 301 SA L HP+ Q Sbjct: 289 SAAQVLQHPWVQ 300 >6FYV-A nrPDB Length = 337 Score = 229 bits (585), Expect = 9e-61, Method: Composition-based stats. Identities = 87/331 (26%), Positives = 152/331 (45%), Gaps = 45/331 (13%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETF 71 +YE V +GEGA+GKV + D G VA+K V+ + E+ VL HL + Sbjct: 15 RYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVG---RYREAARSEIQVLEHLNST 71 Query: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLR 131 + PN V V + D + +VFE + ++ + + I+ M +Q+ + Sbjct: 72 D-PNSV-FRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQ 129 Query: 132 GLDFLHSHRVVHRDLKPQNILVT-------------------SSGQIKLADFGLARIYSF 172 ++FLH +++ H DLKP+NIL + IK+ DFG A Sbjct: 130 SINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATY--D 187 Query: 173 QMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKIL 232 +++V T YRAPEV+L ++ P D+WS+GCI E + +F+ + L + Sbjct: 188 DEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMME 247 Query: 233 DVIGLPGEEDWPRDVALPRQAFHS---------------KSAQPIEKFVTDIDELGK--- 274 ++G P + + + H+ + +P+++F+ DE + Sbjct: 248 RILG-PIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLF 306 Query: 275 DLLLKCLTFNPAKRISAYSALSHPYFQDLER 305 DL+ + L ++P +RI+ AL HP+F L++ Sbjct: 307 DLVRRMLEYDPTQRITLDEALQHPFFDLLKK 337 >4RA4-A nrPDB Length = 355 Score = 229 bits (585), Expect = 9e-61, Method: Composition-based stats. Identities = 69/313 (22%), Positives = 124/313 (39%), Gaps = 45/313 (14%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQT-GEEGMPLSTIREVAVLRHLET 70 + + +G+G++GKV A D K A+K ++ ++ T+ E VL L+ Sbjct: 21 DFNFLMVLGKGSFGKVMLA-DRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDK 79 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQL 129 P + +L +L V E+V+ DL ++ +V + ++ Sbjct: 80 P--PFLTQLHSCFQTV-----DRLYFVMEYVNGGDLMYHIQQVGK--FKEPQAVFYAAEI 130 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALT-SVVVTLWYRAP 188 GL FLH +++RDLK N+++ S G IK+ADFG+ + + T + T Y AP Sbjct: 131 SIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAP 190 Query: 189 EVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA 248 E++ Y VD W+ G + EM +P F G + + I++ Sbjct: 191 EIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNV------------ 238 Query: 249 LPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISA-----YSALSHPYFQDL 303 + + + + +T +PAKR+ H +F+ + Sbjct: 239 ---------------SYPKSLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFRRI 283 Query: 304 ERCKENLDSHLPP 316 + K PP Sbjct: 284 DWEKLENREIQPP 296 >5UNP-A nrPDB Length = 369 Score = 229 bits (585), Expect = 9e-61, Method: Composition-based stats. Identities = 88/338 (26%), Positives = 149/338 (44%), Gaps = 47/338 (13%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLE 69 ++YE V+ +GEG +G+V + D + GG VALK ++ E + E+ VL + Sbjct: 33 QERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIK---NVEKYKEAARLEINVLEKIN 89 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQL 129 + N + V D + + FE + +L P ++ M FQL Sbjct: 90 EKDPDN--KNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQL 147 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQ-------------------IKLADFGLARIY 170 + + FLH +++ H DLKP+NIL +S +++ DFG A Sbjct: 148 CQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFD 207 Query: 171 SFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGK 230 +++V T YRAPEV+L+ ++ P D+WS+GCI E + LF+ + + L Sbjct: 208 HEHH--STIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAM 265 Query: 231 ILDVIGLP----------------GEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGK 274 + ++G G DW + + R ++ +P+ +++T E Sbjct: 266 MERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYV--RENCKPLRRYLTSEAEEHH 323 Query: 275 ---DLLLKCLTFNPAKRISAYSALSHPYFQDLERCKEN 309 DL+ L + PAKR++ AL HP+F L N Sbjct: 324 QLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPN 361 >3LM0-A nrPDB Length = 327 Score = 229 bits (584), Expect = 1e-60, Method: Composition-based stats. Identities = 72/310 (23%), Positives = 127/310 (40%), Gaps = 35/310 (11%) Query: 17 AEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNV 76 E+G G + V + G + A K ++ + + + E+AVL ++ P V Sbjct: 35 KELGRGKFAVVRQCISKSTGQEYAA-KFLKKRRRGQDCRAEILHEIAVLELAKS--CPRV 91 Query: 77 VRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDF 135 + L +V + +++ L+ E+ ++ + V + ++ Q+L G+ + Sbjct: 92 INLHEVY-----ENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYY 146 Query: 136 LHSHRVVHRDLKPQNILVTSS---GQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLL 192 LH + +VH DLKPQNIL++S G IK+ DFG++R L ++ T Y APE+L Sbjct: 147 LHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACELREIMGTPEYLAPEILN 206 Query: 193 QSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQ 252 T D+W++G I + F G + + I V Sbjct: 207 YDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQV------------------ 248 Query: 253 AFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDS 312 + E+ + + +L D + L NP KR +A LSH + Q + Sbjct: 249 -----NVDYSEETFSSVSQLATDFIQSLLVKNPEKRPTAEICLSHSWLQQWDFENLFHPE 303 Query: 313 HLPPSQNTSE 322 S T + Sbjct: 304 ETSSSSQTQD 313 >2YZA-A nrPDB Length = 276 Score = 228 bits (582), Expect = 2e-60, Method: Composition-based stats. Identities = 73/294 (24%), Positives = 115/294 (39%), Gaps = 41/294 (13%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEE-GMPLSTIREVAVLRHLET 70 Y +G G +GKV G + VA+K + Q + RE+ +L+ Sbjct: 12 HYVLGDTLGVGTFGKVKIGEHQLTGHK-VAVKILNRQKIRSLDVVGKIKREIQ---NLKL 67 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQD-LTTYLDKVPEPGVPTETIKDMMFQL 129 F HP++++L+ V + T +V E+V L Y+ V + + Q+ Sbjct: 68 FRHPHIIKLYQVISTP-----TDFFMVMEYVSGGELFDYI--CKHGRVEEMEARRLFQQI 120 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPE 189 L +D+ H H VVHRDLKP+N+L+ + K+ADFGL+ + S L + Y APE Sbjct: 121 LSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRDSCGSPNYAAPE 180 Query: 190 VLLQSSY-ATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA 248 V+ Y VD+WS G I + F KI + E Sbjct: 181 VISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEY------- 233 Query: 249 LPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQD 302 ++ LL+ L +P KR + H +F+ Sbjct: 234 --------------------LNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQ 267 >2HAK-A nrPDB Length = 328 Score = 228 bits (582), Expect = 3e-60, Method: Composition-based stats. Identities = 69/266 (25%), Positives = 116/266 (43%), Gaps = 18/266 (6%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETF 71 Y IG+G + KV AR + GR VA+K + REV +++ L Sbjct: 16 NYRLQKTIGKGNFAKVKLARHVLT-GREVAVKIIDKTQLNPTSLQKLFREVRIMKIL--- 71 Query: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQD-LTTYLDKVPEPGVPTETIKDMMFQLL 130 HPN+V+LF+V +T L LV E+ + YL V + + + Q++ Sbjct: 72 NHPNIVKLFEVIETEKT-----LYLVMEYASGGEVFDYL--VAHGRMKEKEARAKFRQIV 124 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEV 190 + + H +VHRDLK +N+L+ IK+ADFG + ++ L + + Y APE+ Sbjct: 125 SAVQYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPEL 184 Query: 191 LLQSSYATP-VDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVAL 249 Y P VD+WS+G I + F G + + ++L G+ P ++ Sbjct: 185 FQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLR-----GKYRIPFYMST 239 Query: 250 PRQAFHSKSAQPIEKFVTDIDELGKD 275 + K ++++ KD Sbjct: 240 DCENLLKKLLVLNPIKRGSLEQIMKD 265 >3DAK-A nrPDB Length = 290 Score = 228 bits (581), Expect = 3e-60, Method: Composition-based stats. Identities = 70/311 (22%), Positives = 125/311 (40%), Gaps = 41/311 (13%) Query: 6 LCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVL 65 YE IG GA V A VA+KR+ ++ + M ++E+ + Sbjct: 5 WSINRDDYELQEVIGSGATAVVQAAY-CAPKKEKVAIKRINLEKCQTSMD-ELLKEIQAM 62 Query: 66 RHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKV-------PEPGVP 118 HPN+V + V + +L LV + + + K + Sbjct: 63 SQC---HHPNIVSYYTSFVV-----KDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLD 114 Query: 119 TETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALT- 177 TI ++ ++L GL++LH + +HRD+K NIL+ G +++ADFG++ + +T Sbjct: 115 ESTIATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITR 174 Query: 178 -----SVVVTLWYRAPEVLLQ-SSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKI 231 + V T + APEV+ Q Y D+WS G E+ + Sbjct: 175 NKVRKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPP------- 227 Query: 232 LDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISA 291 + V+ L + D P ++ ++ + + + ++ CL +P KR +A Sbjct: 228 MKVLMLTLQNDPPSL----------ETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTA 277 Query: 292 YSALSHPYFQD 302 L H +FQ Sbjct: 278 AELLRHKFFQK 288 >6CKI-A nrPDB Length = 316 Score = 228 bits (581), Expect = 3e-60, Method: Composition-based stats. Identities = 79/312 (25%), Positives = 123/312 (39%), Gaps = 38/312 (12%) Query: 8 RADQQYECVA-EIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLR 66 R + Y+ +GEGA+ +V +L A+K + Q G + REV +L Sbjct: 9 RFEDVYQLQEDVLGEGAHARVQTCINLITSQE-YAVKIIEKQPGH--IRSRVFREVEMLY 65 Query: 67 HLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPGVPTETIKDM 125 + H NV + + + E + LVFE + + +++ K + Sbjct: 66 QCQG--HRNV-----LELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRH--FNELEASVV 116 Query: 126 MFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQI---KLADFGLARIYSFQMALT----- 177 + + LDFLH+ + HRDLKP+NIL Q+ K+ DFGL + Sbjct: 117 VQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTP 176 Query: 178 ---SVVVTLWYRAPEVLLQ-----SSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLG 229 + + Y APEV+ S Y DLWS+G I + P F G D Sbjct: 177 ELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSD--- 233 Query: 230 KILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRI 289 G E P + ++ + +K I KDL+ K L + +R+ Sbjct: 234 -----CGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRL 288 Query: 290 SAYSALSHPYFQ 301 SA L HP+ Q Sbjct: 289 SAAQVLQHPWVQ 300 >2WO6-A nrPDB Length = 382 Score = 228 bits (581), Expect = 3e-60, Method: Composition-based stats. Identities = 85/333 (25%), Positives = 140/333 (42%), Gaps = 49/333 (14%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 +YE + IG+G++G+V KA D +VA+K ++ + +R + ++ Sbjct: 54 DRYEIDSLIGKGSFGQVVKAYDRVE-QEWVAIKIIKNKKAFLNQAQIEVRLLELMNK--- 109 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130 H ++ + V L LVFE + +L L GV + Q+ Sbjct: 110 --HDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMC 167 Query: 131 RGLDFLH--SHRVVHRDLKPQNILVTSSGQ--IKLADFGLARIYSFQMALTSVVVTLWYR 186 L FL ++H DLKP+NIL+ + + IK+ DFG + + + + +YR Sbjct: 168 TALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQL--GQRIYQYIQSRFYR 225 Query: 187 APEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRD 246 +PEVLL Y +D+WS+GCI EM +PLF G+++VDQ+ KI++V+G+P + Sbjct: 226 SPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQA 285 Query: 247 VALPRQAFHSKSAQPIEKFVTDIDEL---------------------------------- 272 + K D Sbjct: 286 PKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVAD 345 Query: 273 ---GKDLLLKCLTFNPAKRISAYSALSHPYFQD 302 KDL+L+ L ++P RI Y AL H +F+ Sbjct: 346 YLKFKDLILRMLDYDPKTRIQPYYALQHSFFKK 378 >4WNO-A nrPDB Length = 287 Score = 228 bits (581), Expect = 3e-60, Method: Composition-based stats. Identities = 78/312 (25%), Positives = 128/312 (41%), Gaps = 47/312 (15%) Query: 2 EKDGLCRADQQYECVAE--IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTI 59 G ++E + IG GA+ VFK R VA+K + + + L Sbjct: 7 PGRGGTETVGKFEFSRKDLIGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQTL-LG 65 Query: 60 REVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVP 118 +E+ +L+ L+ H N+V L+D ++ + LV E+ + DL YL + + Sbjct: 66 KEIKILKELK---HENIVALYDFQEMA-----NSVYLVMEYCNGGDLADYLHAM--RTLS 115 Query: 119 TETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSG---------QIKLADFGLARI 169 +TI+ + Q+ + LHS ++HRDLKPQNIL+++ ++K+ADFG AR Sbjct: 116 EDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARY 175 Query: 170 YSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLG 229 M ++ + Y APEV++ Y DLWS+G I + K F+ SS D Sbjct: 176 LQSNMMAATLCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDL-- 233 Query: 230 KILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRI 289 ++ PR+ + P + Q N R+ Sbjct: 234 RLFYEKNKTLVPTIPRETSAPLRQLLLALLQR----------------------NHKDRM 271 Query: 290 SAYSALSHPYFQ 301 HP+ Sbjct: 272 DFDEFFHHPFLD 283 >6C9D-A nrPDB Length = 459 Score = 228 bits (581), Expect = 3e-60, Method: Composition-based stats. Identities = 69/266 (25%), Positives = 115/266 (43%), Gaps = 18/266 (6%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETF 71 Y IG+G + KV AR + GR VA+K + REV +++ L Sbjct: 22 NYRLQKTIGKGNFAKVKLARHVLT-GREVAVKIIDKTQLNPTSLQKLFREVRIMKIL--- 77 Query: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQD-LTTYLDKVPEPGVPTETIKDMMFQLL 130 HPN+V+LF+V +T L LV E+ + YL V + + + Q++ Sbjct: 78 NHPNIVKLFEVIETEKT-----LYLVMEYASGGEVFDYL--VAHGRMKEKEARAKFRQIV 130 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEV 190 + + H +VHRDLK +N+L+ IK+ADFG + ++ L + Y APE+ Sbjct: 131 SAVQYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDEFCGSPPYAAPEL 190 Query: 191 LLQSSYATP-VDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVAL 249 Y P VD+WS+G I + F G + + ++L G+ P ++ Sbjct: 191 FQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLR-----GKYRIPFYMST 245 Query: 250 PRQAFHSKSAQPIEKFVTDIDELGKD 275 + K ++++ KD Sbjct: 246 DCENLLKKLLVLNPIKRGSLEQIMKD 271 >3ORZ-A nrPDB Length = 316 Score = 227 bits (580), Expect = 4e-60, Method: Composition-based stats. Identities = 78/317 (24%), Positives = 134/317 (42%), Gaps = 51/317 (16%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRV-RVQTGEEGMPLSTIREVAVLRHLE 69 + ++ +GEG++ V AR+L R A+K + + +E RE V+ L Sbjct: 37 EDFKFGKILGEGSFSTVVLARELATS-REYAIKILEKRHIIKENKVPYVTRERDVMSRL- 94 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPGVPTETIKDMMFQ 128 +HP V+L+ + KL + + +L Y+ K+ + + Sbjct: 95 --DHPFFVKLYFCF-----QDDEKLYFGLSYAKNGELLKYIRKIG--SFDETCTRFYTAE 145 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSF---QMALTSVVVTLWY 185 ++ L++LH ++HRDLKP+NIL+ I++ DFG A++ S Q S V T Y Sbjct: 146 IVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQY 205 Query: 186 RAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPR 245 +PE+L + S DLW++GCI ++ P FR ++ KI+ + Sbjct: 206 VSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKL----------- 254 Query: 246 DVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYS------ALSHPY 299 + P + F +DL+ K L + KR+ +HP+ Sbjct: 255 EYDFPEKFF----------------PKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPF 298 Query: 300 FQDLERCKENLDSHLPP 316 F+ + ENL PP Sbjct: 299 FESVTW--ENLHQQTPP 313 >4CQG-A nrPDB Length = 331 Score = 227 bits (580), Expect = 4e-60, Method: Composition-based stats. Identities = 72/307 (23%), Positives = 122/307 (39%), Gaps = 43/307 (14%) Query: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 YE IG G + KV A + G VA+K + +P E+ L+ L Sbjct: 11 YELYETIGTGGFAKVKLACHVLT-GEMVAIKIMDKNALGSDLP-RVKTEIDALKSLR--- 65 Query: 73 HPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPGVPTETIKDMMFQLLR 131 H ++ +L+ V + K+ +V E+ +L Y+ + + + E + + Q+L Sbjct: 66 HQHICQLYHVLET-----KNKIFMVLEYCPGGELFDYI--ISQDRLSEEETRVVFRQILS 118 Query: 132 GLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLAR--IYSFQMALTSVVVTLWYRAPE 189 + ++HS HRDLKP+N+L + ++KL DFGL + L +L Y APE Sbjct: 119 AVAYVHSQGYAHRDLKPENLLFDENHKLKLIDFGLCAKPKGNKDYHLQECCGSLAYAAPE 178 Query: 190 VLLQSSY-ATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA 248 ++ SY + D+WS+G + + F + + KI+ Sbjct: 179 LIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRG-------------- 224 Query: 249 LPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKE 308 + + LL + L +P KRIS + L+HP+ C Sbjct: 225 -------------KYEVPKWLSPSSILLLQQMLQVDPKKRISMRNLLNHPWVMQDYSCPV 271 Query: 309 NLDSHLP 315 S P Sbjct: 272 EWQSKTP 278 >3ZUT-A nrPDB Length = 362 Score = 227 bits (579), Expect = 5e-60, Method: Composition-based stats. Identities = 78/299 (26%), Positives = 119/299 (39%), Gaps = 39/299 (13%) Query: 6 LCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVL 65 + +YE V +IG G +G RD K VA+K + E + + RE+ Sbjct: 14 IMHDSDRYELVKDIGSGNFGVARLMRD-KQSNELVAVKYIERG---EKIDENVKREIINH 69 Query: 66 RHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPG-VPTETIKD 124 R L HPN+VR +V T L +V E+ +++ G + + Sbjct: 70 RSLR---HPNIVRFKEVILTP-----THLAIVMEYASGG--ELFERICNAGRFSEDEARF 119 Query: 125 MMFQLLRGLDFLHSHRVVHRDLKPQNILVTSS--GQIKLADFGLARIYSFQMALTSVVVT 182 QL+ G+ + H+ +V HRDLK +N L+ S ++K+ FG ++ S V T Sbjct: 120 FFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICAFGYSKSSVLHSQPKSTVGT 179 Query: 183 LWYRAPEVLLQSSYATPV-DLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEE 241 Y APEVLL+ Y V D+WS G M F + K + I L + Sbjct: 180 PAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRI-LNVQY 238 Query: 242 DWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 P V I + L+ + +PAKRIS +H +F Sbjct: 239 AIPDYV--------------------HISPECRHLISRIFVADPAKRISIPEIRNHEWF 277 >4AF3-A nrPDB Length = 292 Score = 227 bits (578), Expect = 6e-60, Method: Composition-based stats. Identities = 80/309 (25%), Positives = 140/309 (45%), Gaps = 47/309 (15%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRV-RVQTGEEGMPLSTIREVAVLRHLE 69 +E +G+G +G V+ AR+ K VALK + + Q +EG+ RE+ + HL Sbjct: 23 DDFEIGRPLGKGKFGNVYLAREKK-SHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHL- 80 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPGVPTETIKDMMFQ 128 HPN++RL++ R ++ L+ E+ +L L K + +M + Sbjct: 81 --HHPNILRLYNYFYDRR-----RIYLILEYAPRGELYKELQKSC--TFDEQRTATIMEE 131 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAP 188 L L + H +V+HRD+KP+N+L+ G++K+ADFG + +++ + ++ TL Y P Sbjct: 132 LADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWS-VHAPSLRRKTMCGTLDYLPP 190 Query: 189 EVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA 248 E++ + VDLW +G + E+ P F +S + +I+ V Sbjct: 191 EMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKV-------------- 236 Query: 249 LPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKE 308 KF + +DL+ K L NP++R+ +HP+ + Sbjct: 237 -------------DLKFPASVPTGAQDLISKLLRHNPSERLPLAQVSAHPWVR------A 277 Query: 309 NLDSHLPPS 317 N LPPS Sbjct: 278 NSRRVLPPS 286 >3UC3-A nrPDB Length = 361 Score = 227 bits (578), Expect = 7e-60, Method: Composition-based stats. Identities = 75/298 (25%), Positives = 114/298 (38%), Gaps = 37/298 (12%) Query: 6 LCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVL 65 + +Y+ V +IG G +G RD K VA+K + + + RE+ Sbjct: 15 IMHDSDRYDFVKDIGSGNFGVARLMRD-KLTKELVAVKYIERGAA---IDENVQREIINH 70 Query: 66 RHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDM 125 R L HPN+VR +V T L ++ E+ Y + + Sbjct: 71 RSLR---HPNIVRFKEVILTP-----THLAIIMEYASGG-ELYERICNAGRFSEDEARFF 121 Query: 126 MFQLLRGLDFLHSHRVVHRDLKPQNILVTSS--GQIKLADFGLARIYSFQMALTSVVVTL 183 QLL G+ + HS ++ HRDLK +N L+ S ++K+ DFG ++ S V T Sbjct: 122 FQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTP 181 Query: 184 WYRAPEVLLQSSYATP-VDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEED 242 Y APEVLL+ Y D+WS G M F + K + I L + Sbjct: 182 AYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRI-LSVKYS 240 Query: 243 WPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 P D+ I L+ + +PA RIS +H +F Sbjct: 241 IPDDI--------------------RISPECCHLISRIFVADPATRISIPEIKTHSWF 278 >5DBX-A nrPDB Length = 328 Score = 226 bits (577), Expect = 9e-60, Method: Composition-based stats. Identities = 77/329 (23%), Positives = 129/329 (39%), Gaps = 41/329 (12%) Query: 5 GLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAV 64 G YE IG GA V +A K VA+KR+ ++ + M ++E+ Sbjct: 5 GWPICRDAYELQEVIGSGATAVV-QAALCKPRQERVAIKRINLEKCQTSMD-ELLKEIQA 62 Query: 65 LRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDK-------VPEPGV 117 + HPNVV + V + +L LV + + + K + Sbjct: 63 MSQCS---HPNVVTYYTSFVV-----KDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVL 114 Query: 118 PTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALT 177 I ++ ++L GLD+LH + +HRDLK NIL+ G +++ADFG++ + +T Sbjct: 115 EEAIIATILKEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVT 174 Query: 178 ------SVVVTLWYRAPEVLLQ-SSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGK 230 V T + APEV+ Q Y D+WS G E+ + Sbjct: 175 RNKVRKDFVGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPP------ 228 Query: 231 ILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRIS 290 + V+ L + D P K + + LL CL +P+KR + Sbjct: 229 -MKVLMLTLQNDPPTLETGVEDKEMMKKYG----------KSFRKLLSLCLQKDPSKRPT 277 Query: 291 AYSALSHPYFQDLERCKENLDSHLPPSQN 319 A L +FQ + + ++ L + + Sbjct: 278 AAELLKCKFFQKAKNREYLIEKLLTRTPD 306 >4MD7-E nrPDB Length = 391 Score = 226 bits (576), Expect = 1e-59, Method: Composition-based stats. Identities = 85/320 (26%), Positives = 150/320 (46%), Gaps = 28/320 (8%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLE 69 Y+ V ++G G Y +VF+A ++ N + V+ + RE+ +L +L Sbjct: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKV------VVKILKPVKKKKIKREIKILENLR 89 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQL 129 PN++ L D+ + LVFEHV+ L + + I+ M+++ Sbjct: 90 GG--PNIITLADIVKDPVSRTPA---LVFEHVNNTDFKQLYQ----TLTDYDIRFYMYEI 140 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQ-IKLADFGLARIYSFQMALTSVVVTLWYRAP 188 L+ LD+ HS ++HRD+KP N+++ + ++L D+GLA Y V + +++ P Sbjct: 141 LKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGP 200 Query: 189 EVLL-QSSYATPVDLWSVGCIFAEM-FRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRD 246 E+L+ Y +D+WS+GC+ A M FR++P F G + DQL +I V+G D+ Sbjct: 201 ELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDK 260 Query: 247 VALP-----RQAFHSKSAQPIEKFVTD-----IDELGKDLLLKCLTFNPAKRISAYSALS 296 + S + E+FV + D L K L ++ R++A A+ Sbjct: 261 YNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAME 320 Query: 297 HPYFQDLERCKENLDSHLPP 316 HPYF + + + + S P Sbjct: 321 HPYFYTVVKDQARMGSSSMP 340 >6QAU-A nrPDB Length = 280 Score = 226 bits (576), Expect = 1e-59, Method: Composition-based stats. Identities = 78/304 (25%), Positives = 133/304 (43%), Gaps = 45/304 (14%) Query: 9 ADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHL 68 D +Y +G GA+ VF+ R + VA+K + + + L +E+ +L+ L Sbjct: 9 GDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQIL-LGKEIKILKEL 67 Query: 69 ETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMF 127 + H N+V L+DV + + LV E+ + DL YL + + +TI+ + Sbjct: 68 Q---HENIVALYDV-----QELPNSVFLVMEYCNGGDLADYLQ--AKGTLSEDTIRVFLH 117 Query: 128 QLLRGLDFLHSHRVVHRDLKPQNILVT---------SSGQIKLADFGLARIYSFQMALTS 178 Q+ + LHS ++HRDLKPQNIL++ S +IK+ADFG AR M Sbjct: 118 QIAAAMRILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAAD 177 Query: 179 VVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLP 238 + + Y APEV++ Y DLWS+G + + KP F+ +S D + + Sbjct: 178 LCGSPMYMAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQD--------LRMF 229 Query: 239 GEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHP 298 E++ ++PR+ + + N R+ + SHP Sbjct: 230 YEKNRSLMPSIPRETSPYLANLLLGLL----------------QRNQKDRMDFEAFFSHP 273 Query: 299 YFQD 302 + + Sbjct: 274 FLEQ 277 >4D2V-A nrPDB Length = 356 Score = 226 bits (576), Expect = 1e-59, Method: Composition-based stats. Identities = 74/307 (24%), Positives = 126/307 (41%), Gaps = 43/307 (14%) Query: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 YE IG G + KV A + G VA+K + T +P E+ L++L Sbjct: 31 YELHETIGTGGFAKVKLACHILT-GEMVAIKIMDKNTLGSDLP-RIKTEIEALKNLR--- 85 Query: 73 HPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPGVPTETIKDMMFQLLR 131 H ++ +L+ V + K+ +V E+ +L Y+ + + + E + + Q++ Sbjct: 86 HQHICQLYHVLETA-----NKIFMVLEYCPGGELFDYI--ISQDRLSEEETRVVFRQIVS 138 Query: 132 GLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLAR--IYSFQMALTSVVVTLWYRAPE 189 + ++HS HRDLKP+N+L ++KL DFGL + L + L Y APE Sbjct: 139 AVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQACCGALAYAAPE 198 Query: 190 VLLQSSY-ATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA 248 ++ SY + D+WS+G + + F + + KI+ G+ D P+ Sbjct: 199 LIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDTAAALVAKIMR-----GKYDVPK--- 250 Query: 249 LPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKE 308 + LL + L +P KRIS + L+HP+ Sbjct: 251 -------------------WLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPV 291 Query: 309 NLDSHLP 315 S P Sbjct: 292 EWQSKNP 298 >4B8L-A nrPDB Length = 286 Score = 226 bits (576), Expect = 1e-59, Method: Composition-based stats. Identities = 71/293 (24%), Positives = 133/293 (45%), Gaps = 41/293 (13%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRV-RVQTGEEGMPLSTIREVAVLRHLE 69 ++ +G+G +G V+ AR+ +N +ALK + + Q +EG+ RE+ + HL Sbjct: 15 DDFDIGRPLGKGKFGNVYLAREKQN-KFIMALKVLFKSQLEKEGVEHQLRREIEIQSHLR 73 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPGVPTETIKDMMFQ 128 HPN++R+++ ++ L+ E +L L K + M + Sbjct: 74 ---HPNILRMYNYF-----HDRKRIYLMLEFAPRGELYKELQK--HGRFDEQRSATFMEE 123 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAP 188 L L + H +V+HRD+KP+N+L+ G++K+ADFG + +++ + ++ TL Y P Sbjct: 124 LADALHYCHERKVIHRDIKPENLLMGYKGELKIADFGWS-VHAPSLRRRTMCGTLDYLPP 182 Query: 189 EVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA 248 E++ ++ VDLW G + E P F S + +I++V Sbjct: 183 EMIEGKTHDEKVDLWCAGVLCYEFLVGMPPFDSPSHTETHRRIVNV-------------- 228 Query: 249 LPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQ 301 KF + + KDL+ K L ++P +R+ + HP+ + Sbjct: 229 -------------DLKFPPFLSDGSKDLISKLLRYHPPQRLPLKGVMEHPWVK 268 >4I6B-A nrPDB Length = 308 Score = 225 bits (575), Expect = 1e-59, Method: Composition-based stats. Identities = 60/293 (20%), Positives = 119/293 (40%), Gaps = 37/293 (12%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 ++Y +G+G + K ++ DL N + A + + +E+ + R L Sbjct: 28 KRYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKIDKEIELHRIL-- 85 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130 H +VV+ + + + + ++ E+ + ++ K + ++ + Q++ Sbjct: 86 -HHKHVVQFYHYF-----EDKENIYILLEYCSRRSMAHILK-ARKVLTEPEVRYYLRQIV 138 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLA-RIYSFQMALTSVVVTLWYRAPE 189 GL +LH ++HRDLK N + S ++K+ DFGLA R+ + ++ T Y +PE Sbjct: 139 SGLKYLHEQEILHRDLKLGNFFINESMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPE 198 Query: 190 VLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVAL 249 VL + + D+W++GC+ M +P F ++ + I + P + Sbjct: 199 VLNKQGHGAESDIWALGCVMYTMLLGRPPFETTNLKETYRSIRE-----ARYTMPSSLLA 253 Query: 250 PRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQD 302 P K L+ L+ NP R S + H +F Sbjct: 254 P----------------------AKHLIASMLSKNPEDRPSLDDIIRHDFFTQ 284 >3UDB-A nrPDB Length = 317 Score = 225 bits (574), Expect = 2e-59, Method: Composition-based stats. Identities = 80/299 (26%), Positives = 121/299 (40%), Gaps = 39/299 (13%) Query: 6 LCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVL 65 + +YE V +IG G +G RD K VA+K + E + + RE+ Sbjct: 14 IMHDSDRYELVKDIGAGNFGVARLMRD-KQANELVAVKYIERG---EKIDENVKREIINH 69 Query: 66 RHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPG-VPTETIKD 124 R L HPN+VR +V T L +V E+ +++ G + + Sbjct: 70 RSLR---HPNIVRFKEVILTP-----THLAIVMEYASGG--ELFERICNAGRFSEDEARF 119 Query: 125 MMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSG--QIKLADFGLARIYSFQMALTSVVVT 182 QL+ G+ + H+ +V HRDLK +N L+ S ++K+ADFG ++ S V T Sbjct: 120 FFQQLISGVSYAHAMQVAHRDLKLENTLLDGSPAPRLKIADFGYSKASVLHSQPKSAVGT 179 Query: 183 LWYRAPEVLLQSSYATPV-DLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEE 241 Y APEVLL+ Y V D+WS G M F + K + I L + Sbjct: 180 PAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRI-LNVQY 238 Query: 242 DWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 P V I + L+ + +PAKRIS +H +F Sbjct: 239 AIPDYV--------------------HISPECRHLISRIFVADPAKRISIPEIRNHEWF 277 >2PVN-A nrPDB Length = 352 Score = 225 bits (573), Expect = 2e-59, Method: Composition-based stats. Identities = 84/313 (26%), Positives = 153/313 (48%), Gaps = 28/313 (8%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLE 69 YE V ++G G Y +VF+ ++ N + ++ + RE+ +L++L Sbjct: 51 QDDYEVVRKVGRGKYSEVFEGINVNNNEK------CIIKILKPVKKKKIKREIKILQNL- 103 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQL 129 PN+V+L D+ + + L+FE+V+ L P + I+ +++L Sbjct: 104 -CGGPNIVKLLDIVRDQHSKTPS---LIFEYVNNTDFKVL----YPTLTDYDIRYYIYEL 155 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQ-IKLADFGLARIYSFQMALTSVVVTLWYRAP 188 L+ LD+ HS ++HRD+KP N+++ + ++L D+GLA Y V + +++ P Sbjct: 156 LKALDYCHSQGIMHRDVKPHNVMIDHELRKLRLIDWGLAEFYHPGKEYNVRVASRYFKGP 215 Query: 189 EVLLQ-SSYATPVDLWSVGCIFA-EMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRD 246 E+L+ Y +D+WS+GC+FA +FR++P F G + DQL KI V+G G + Sbjct: 216 ELLVDLQDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKIAKVLGTDGLNAYLNK 275 Query: 247 VALP-----RQAFHSKSAQPIEKFVTD-----IDELGKDLLLKCLTFNPAKRISAYSALS 296 + S +P KF+ + D L K L ++ +R++A A++ Sbjct: 276 YRIELDPQLEALVGRHSRKPWLKFMNADNQHLVSPEAIDFLDKLLRYDHQERLTALEAMT 335 Query: 297 HPYFQDLERCKEN 309 HPYFQ + + + Sbjct: 336 HPYFQQVRAAENS 348 >3FXW-A nrPDB Length = 336 Score = 224 bits (572), Expect = 3e-59, Method: Composition-based stats. Identities = 71/299 (23%), Positives = 123/299 (41%), Gaps = 36/299 (12%) Query: 9 ADQQYEC-VAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRH 67 Y+ +G G GKV + + G + ALK + +EV H Sbjct: 26 VTDDYQLSKQVLGLGVNGKVLECFHRRTGQK-CALKLL-------YDSPKARQEVD--HH 75 Query: 68 LETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQD-LTTYLDKVPEPGVPTETIKDMM 126 + P++V + DV + L ++ E ++ L + + + + ++M Sbjct: 76 WQASGGPHIVCILDVYENMHHGKRC-LLIIMECMEGGELFSRIQERGDQAFTEREAAEIM 134 Query: 127 FQLLRGLDFLHSHRVVHRDLKPQNILVTS---SGQIKLADFGLARIYSFQMALTSVVVTL 183 + + FLHSH + HRD+KP+N+L TS +KL DFG A+ + Q AL + T Sbjct: 135 RDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKE-TTQNALQTPCYTP 193 Query: 184 WYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDW 243 +Y APEVL Y D+WS+G I + P F ++ G Sbjct: 194 YYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGFPPFYSNT------------GQAISPGM 241 Query: 244 PRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQD 302 R + L + F + +++ E K L+ L +P +R++ ++HP+ Sbjct: 242 KRRIRLGQYGFPNPE-------WSEVSEDAKQLIRLLLKTDPTERLTITQFMNHPWINQ 293 >2H8H-A nrPDB Length = 535 Score = 224 bits (572), Expect = 3e-59, Method: Composition-based stats. Identities = 68/312 (21%), Positives = 124/312 (39%), Gaps = 46/312 (14%) Query: 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR 60 + KD + ++G+G +G+V+ NG VA+K ++ T P + ++ Sbjct: 257 LAKDAWEIPRESLRLEVKLGQGCFGEVWMGTW--NGTTRVAIKTLKPGTMS---PEAFLQ 311 Query: 61 EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPGVPT 119 E V++ L H +V+L+ V + E + +V E++ L +L + Sbjct: 312 EAQVMKKLR---HEKLVQLYAVVS------EEPIYIVTEYMSKGSLLDFLKGETGKYLRL 362 Query: 120 ETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSF--QMALT 177 + DM Q+ G+ ++ VHRDL+ NILV + K+ADFGLAR+ A Sbjct: 363 PQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQ 422 Query: 178 SVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILDVIG 236 + + APE L + D+WS G + E+ + + G + + L ++ Sbjct: 423 GAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYR 482 Query: 237 LPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALS 296 +P + P E DL+ +C P +R + + Sbjct: 483 MPCPPECP--------------------------ESLHDLMCQCWRKEPEERPTFEYLQA 516 Query: 297 HPYFQDLERCKE 308 + +D E Sbjct: 517 --FLEDYFTSTE 526 >4U41-A nrPDB Length = 332 Score = 224 bits (572), Expect = 4e-59, Method: Composition-based stats. Identities = 74/298 (24%), Positives = 119/298 (39%), Gaps = 39/298 (13%) Query: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 +E V +G G YG+V+K R +K G+ A+K + V EE E+ +L+ + Sbjct: 26 FELVEVVGNGTYGQVYKGRHVKT-GQLAAIKVMDVTEDEEEEIKL---EINMLK--KYSH 79 Query: 73 HPNVVRLFDVC-TVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPGVPTETIKDMMFQLL 130 H N+ + S + +L LV E +T + + + I + ++L Sbjct: 80 HRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREIL 139 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQ-MALTSVVVTLWYRAPE 189 RGL LH H V+HRD+K QN+L+T + ++KL DFG++ + + T ++ APE Sbjct: 140 RGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 199 Query: 190 VLL-----QSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWP 244 V+ ++Y DLWS G EM P + Sbjct: 200 VIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPM------------------- 240 Query: 245 RDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQD 302 R F P + + CL N +R S L HP+ +D Sbjct: 241 ------RALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRD 292 >6F3F-A nrPDB Length = 455 Score = 224 bits (571), Expect = 4e-59, Method: Composition-based stats. Identities = 68/312 (21%), Positives = 125/312 (40%), Gaps = 46/312 (14%) Query: 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR 60 + KD + ++G+G +G+V+ NG VA+K ++ T P + ++ Sbjct: 177 LAKDAWEIPRESLRLEVKLGQGCFGEVWMGTW--NGTTRVAIKTLKPGTMS---PEAFLQ 231 Query: 61 EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPGVPT 119 E V++ L H +V+L+ V + E + +V E+++ L +L + Sbjct: 232 EAQVMKKLR---HEKLVQLYAVVS------EEPIYIVTEYMNKGSLLDFLKGETGKYLRL 282 Query: 120 ETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSF--QMALT 177 + DM Q+ G+ ++ VHRDL+ NILV + K+ADFGLAR+ A Sbjct: 283 PQLVDMSAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQ 342 Query: 178 SVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILDVIG 236 + + APE L + D+WS G + E+ + + G + + L ++ Sbjct: 343 GAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYR 402 Query: 237 LPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALS 296 +P + P E DL+ +C P +R + + Sbjct: 403 MPCPPECP--------------------------ESLHDLMCQCWRKEPEERPTFEYLQA 436 Query: 297 HPYFQDLERCKE 308 + +D E Sbjct: 437 --FLEDYFTSTE 446 >3A8W-A nrPDB Length = 345 Score = 224 bits (571), Expect = 5e-59, Method: Composition-based stats. Identities = 72/315 (22%), Positives = 129/315 (40%), Gaps = 37/315 (11%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR-EVAVLRHLE 69 Q ++ + IG G+Y KV R K R A+K V+ + + + ++ E V Sbjct: 9 QDFDLLRVIGRGSYAKVLLVRLKKTD-RIYAMKVVKKELVNDDEDIDWVQTEKHVFEQ-- 65 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQ 128 HP +V L E++L V E+V+ DL ++ + + +P E + + Sbjct: 66 ASNHPFLVGLHSCFQT-----ESRLFFVIEYVNGGDLMFHMQR--QRKLPEEHARFYSAE 118 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARI-YSFQMALTSVVVTLWYRA 187 + L++LH +++RDLK N+L+ S G IKL D+G+ + ++ T Y A Sbjct: 119 ISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIA 178 Query: 188 PEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDV 247 PE+L Y VD W++G + EM + F D++G D + Sbjct: 179 PEILRGEDYGFSVDWWALGVLMFEMMAGRSPF-------------DIVGSSDNPDQNTED 225 Query: 248 ALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISA------YSALSHPYFQ 301 L + + P + +L L +P +R+ HP+F+ Sbjct: 226 YLFQVILEKQIRIP-----RSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFR 280 Query: 302 DLERCKENLDSHLPP 316 +++ +PP Sbjct: 281 NVDWDMMEQKQVVPP 295 >1VZO-A nrPDB Length = 355 Score = 224 bits (570), Expect = 5e-59, Method: Composition-based stats. Identities = 71/310 (22%), Positives = 131/310 (42%), Gaps = 46/310 (14%) Query: 11 QQYECVAEIGEGAYGKVFKARDLK--NGGRFVALKRVRVQT--GEEGMPLSTIREVAVLR 66 + +E + +G GAYGKVF R + + G+ A+K ++ T + T E VL Sbjct: 54 ENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLE 113 Query: 67 HLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQD-LTTYLDKVPEPGVPTETIKDM 125 H+ + P +V L ETKL L+ ++++ L T+L + ++ Sbjct: 114 HIR--QSPFLVTLHYAFQT-----ETKLHLILDYINGGELFTHLSQRER--FTEHEVQIY 164 Query: 126 MFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY--SFQMALTSVVVTL 183 + +++ L+ LH +++RD+K +NIL+ S+G + L DFGL++ + T+ Sbjct: 165 VGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYDFCGTI 224 Query: 184 WYRAPEVLLQS--SYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEE 241 Y AP+++ + VD WS+G + E+ F + + +I I Sbjct: 225 EYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRI------ 278 Query: 242 DWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRI-----SAYSALS 296 + + ++ L KDL+ + L +P KR+ A Sbjct: 279 -----------------LKSEPPYPQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKE 321 Query: 297 HPYFQDLERC 306 H +FQ + Sbjct: 322 HLFFQKINWD 331 >6ED6-A nrPDB Length = 415 Score = 223 bits (569), Expect = 8e-59, Method: Composition-based stats. Identities = 79/323 (24%), Positives = 126/323 (39%), Gaps = 45/323 (13%) Query: 4 DGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRV-RVQTGEEGMPLSTIREV 62 GL + Y+ V IG GA+G+V R K + A+K + + + + E Sbjct: 81 RGLQMKAEDYDVVKVIGRGAFGEVQLVRH-KASQKVYAMKLLSKFEMIKRSDSAFFWEER 139 Query: 63 AVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETI 122 ++ + P VV+LF R L +V E++ ++ + VP + Sbjct: 140 DIMAFANS---PWVVQLFYAFQDDRY-----LYMVMEYMPGG--DLVNLMSNYDVPEKWA 189 Query: 123 KDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQM--ALTSVV 180 K +++ LD +HS ++HRD+KP N+L+ G +KLADFG + V Sbjct: 190 KFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAV 249 Query: 181 VTLWYRAPEVLLQSS----YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIG 236 T Y +PEVL Y D WSVG EM F S V KI+ Sbjct: 250 GTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIM---- 305 Query: 237 LPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRI---SAYS 293 D + P A +I + K+L+ LT + R+ Sbjct: 306 -----DHKNSLCFPEDA--------------EISKHAKNLICAFLT-DREVRLGRNGVEE 345 Query: 294 ALSHPYFQDLERCKENLDSHLPP 316 HP+F++ + +N+ P Sbjct: 346 IRQHPFFKNDQWHWDNIRETAAP 368 >3NYO-A nrPDB Length = 576 Score = 223 bits (568), Expect = 9e-59, Method: Composition-based stats. Identities = 69/310 (22%), Positives = 121/310 (39%), Gaps = 37/310 (11%) Query: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 + +G+G +G+V + G + K + + + + E +L + + Sbjct: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNS-- 243 Query: 73 HPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQLLR 131 VV L + + L LV ++ DL ++ + + G P ++ Sbjct: 244 -RFVVSL-----AYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICC 297 Query: 132 GLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVL 191 GL+ LH R+V+RDLKP+NIL+ G I+++D GLA + V T+ Y APEV+ Sbjct: 298 GLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVV 357 Query: 192 LQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPR 251 Y D W++GC+ EM + F+ R + R Sbjct: 358 KNERYTFSPDWWALGCLLYEMIAGQSPFQ-----------------------QRKKKIKR 394 Query: 252 QAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRI-----SAYSALSHPYFQDLERC 306 + + E++ + L + L +PA+R+ SA HP F+ L Sbjct: 395 EEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFK 454 Query: 307 KENLDSHLPP 316 + PP Sbjct: 455 RLGAGMLEPP 464 >2DQ7-X nrPDB Length = 283 Score = 223 bits (568), Expect = 1e-58, Method: Composition-based stats. Identities = 66/310 (21%), Positives = 126/310 (40%), Gaps = 46/310 (14%) Query: 3 KDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREV 62 KD + + + +G G +G+V+ NG VA+K ++ T P S + E Sbjct: 1 KDVWEIPRESLQLIKRLGNGQFGEVWMGTW--NGNTKVAIKTLKPGTMS---PESFLEEA 55 Query: 63 AVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPGVPTET 121 +++ L+ H +V+L+ V + E + +V E+++ L +L + Sbjct: 56 QIMKKLK---HDKLVQLYAVVS------EEPIYIVTEYMNKGSLLDFLKDGEGRALKLPN 106 Query: 122 IKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSF--QMALTSV 179 + DM Q+ G+ ++ +HRDL+ NILV + K+ADFGLAR+ A Sbjct: 107 LVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGA 166 Query: 180 VVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILDVIGLP 238 + + APE L + D+WS G + E+ + + G ++ + L ++ +P Sbjct: 167 KFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMP 226 Query: 239 GEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHP 298 +D P + +L++ C +P +R + Sbjct: 227 CPQDCPISL--------------------------HELMIHCWKKDPEERPTFEYLQ--S 258 Query: 299 YFQDLERCKE 308 + +D E Sbjct: 259 FLEDYFTATE 268 >5N23-A nrPDB Length = 352 Score = 222 bits (567), Expect = 1e-58, Method: Composition-based stats. Identities = 65/304 (21%), Positives = 120/304 (39%), Gaps = 46/304 (15%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRV-RVQTGEEGMPLSTIREVAVLRHLE 69 Q+E + +G G++G+V + + G A+K + + + + T+ E + + Sbjct: 42 DQFERIRTLGTGSFGRVMLVKHKETGNH-YAMKILDKQKVVKLKQIEHTLNEKRIQ---Q 97 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPGVPTETIKDMMFQ 128 P +V+L + L +V E+ ++ ++L ++ + Q Sbjct: 98 AVNFPFLVKL-----EFSFKDNSNLYMVLEYAPGGEMFSHLRRIGR--FSEPHARFYAAQ 150 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAP 188 ++ ++LHS +++RDLKP+N+L+ G IK+ADFG A+ + T + T Y AP Sbjct: 151 IVLTFEYLHSLDLIYRDLKPENLLIDQQGYIKVADFGFAKRVKGRTPWT-LCGTPEYLAP 209 Query: 189 EVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA 248 E++L Y VD W++G + EM P F + KI+ Sbjct: 210 EIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKV------------ 257 Query: 249 LPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRI-----SAYSALSHPYFQDL 303 +F + KDLL L + KR +H +F Sbjct: 258 ---------------RFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATT 302 Query: 304 ERCK 307 + Sbjct: 303 DWIA 306 >5X3F-B nrPDB Length = 393 Score = 222 bits (566), Expect = 1e-58, Method: Composition-based stats. Identities = 63/304 (20%), Positives = 121/304 (39%), Gaps = 47/304 (15%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRV-RVQTGEEGMPLSTIREVAVLRHLE 69 Q++ + +G G++G+V + ++G A+K + + + + T+ E +L + Sbjct: 84 DQFDRIKTLGTGSFGRVMLVKHKESGNH-YAMKILDKQKVVKLKQIEHTLNEKRIL---Q 139 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPGVPTETIKDMMFQ 128 P +V+L + L +V E+V ++ ++L ++ + Q Sbjct: 140 AVNFPFLVKL-----EFSFKDNSNLYMVMEYVAGGEMFSHLRRIGR--FSEPHARFYAAQ 192 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAP 188 ++ ++LHS +++RDLKP+N+L+ G I++ DFG A+ ++ T Y AP Sbjct: 193 IVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK--GRTWTLCGTPEYLAP 250 Query: 189 EVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA 248 E++L Y VD W++G + EM P F + KI+ Sbjct: 251 EIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKV------------ 298 Query: 249 LPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRI-----SAYSALSHPYFQDL 303 +F + KDLL L + KR +H +F Sbjct: 299 ---------------RFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATT 343 Query: 304 ERCK 307 + Sbjct: 344 DWIA 347 >1U5R-A nrPDB Length = 348 Score = 222 bits (566), Expect = 2e-58, Method: Composition-based stats. Identities = 75/295 (25%), Positives = 124/295 (42%), Gaps = 40/295 (13%) Query: 9 ADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHL 68 ++ + + EIG G++G V+ ARD++N VA+K++ + I + +R L Sbjct: 52 PEKLFSDLREIGHGSFGAVYFARDVRNS-EVVAIKKMSYSGKQSNEKWQDI--IKEVRFL 108 Query: 69 ETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQ 128 + HPN ++ T LV E+ + L+ V + + I + Sbjct: 109 QKLRHPNTIQYRGCYLREHTA-----WLVMEYCLGSASDLLE-VHKKPLQEVEIAAVTHG 162 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAP 188 L+GL +LHSH ++HRD+K NIL++ G +KL DFG A I + S V T ++ AP Sbjct: 163 ALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAP---ANSFVGTPYWMAP 219 Query: 189 EVLL---QSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPR 245 EV+L + Y VD+WS+G E+ RKP + + L I Sbjct: 220 EVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQ------------ 267 Query: 246 DVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 + E ++ + CL P R ++ L H + Sbjct: 268 -------------NESPALQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFV 309 >4B6L-A nrPDB Length = 281 Score = 222 bits (566), Expect = 2e-58, Method: Composition-based stats. Identities = 66/297 (22%), Positives = 122/297 (41%), Gaps = 39/297 (13%) Query: 8 RADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRV-RVQTGEEGMPLSTIREVAVLR 66 R+ + Y +G+G + + ++A D + G A+K + + + + + E+ + R Sbjct: 6 RSGRTYLKGRLLGKGGFARCYEATDTETGS-AYAVKVIPQSRVAKPHQREKILNEIELHR 64 Query: 67 HLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMM 126 L+ H ++VR + + + E + ++ K + ++ + Sbjct: 65 DLQ---HRHIVRF-----SHHFEDADNIYIFLELCSRKSLAHIWKARH-TLLEPEVRYYL 115 Query: 127 FQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLA-RIYSFQMALTSVVVTLWY 185 Q+L GL +LH ++HRDLK N +T + ++K+ DFGLA R+ + ++ T Y Sbjct: 116 RQILSGLKYLHQRGILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNY 175 Query: 186 RAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPR 245 APEVLL+ + D+WS+GC+ + P F + + I V P Sbjct: 176 VAPEVLLRQGHGPEADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQV-----HYTLPA 230 Query: 246 DVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQD 302 ++LP + LL L +P R S L H +F Sbjct: 231 SLSLP----------------------ARQLLAAILRASPRDRPSIDQILRHDFFTK 265 >4EBW-A nrPDB Length = 304 Score = 222 bits (565), Expect = 2e-58, Method: Composition-based stats. Identities = 66/294 (22%), Positives = 122/294 (41%), Gaps = 43/294 (14%) Query: 7 CRADQQYECVAEIGEGAYGKVFKARDL--KNGGRFVALKRVRVQTGEEGMPLSTIREVAV 64 ++ E IGEG +G V + + +N VA+K + + + ++E Sbjct: 34 EIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCK-NCTSDSVREKFLQEALT 92 Query: 65 LRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPGVPTETIK 123 +R F+HP++V+L V T E + ++ E +L ++L +V + + ++ Sbjct: 93 MRQ---FDHPHIVKLIGVIT------ENPVWIIMELCTLGELRSFL-QVRKYSLDLASLI 142 Query: 124 DMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVV-- 181 +QL L +L S R VHRD+ +N+LV+S+ +KL DFGL+R + Sbjct: 143 LYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKL 202 Query: 182 TLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILDVIGLPGE 240 + + APE + + + D+W G E+ F+G + D +G+I + LP Sbjct: 203 PIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMP 262 Query: 241 EDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSA 294 + P L+ KC ++P++R Sbjct: 263 PNCP--------------------------PTLYSLMTKCWAYDPSRRPRFTEL 290 >4APC-A nrPDB Length = 350 Score = 221 bits (564), Expect = 3e-58, Method: Composition-based stats. Identities = 69/288 (23%), Positives = 127/288 (44%), Gaps = 37/288 (12%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 ++Y + +IGEG++GK + ++G ++V +K + + + REVAVL +++ Sbjct: 24 EKYVRLQKIGEGSFGKAILVKSTEDGRQYV-IKEINISRMSSKEREESRREVAVLANMK- 81 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQL 129 HPN+V+ + + L +V ++ + DL ++ + I D Q+ Sbjct: 82 --HPNIVQYRESF-----EENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQI 134 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVV-VTLWYRAP 188 L +H +++HRD+K QNI +T G ++L DFG+AR+ + + L T +Y +P Sbjct: 135 CLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARACIGTPYYLSP 194 Query: 189 EVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA 248 E+ Y D+W++GC+ E+ K F S + + KI+ P + D+ Sbjct: 195 EICENKPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDL- 253 Query: 249 LPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALS 296 + L+ + NP R S S L Sbjct: 254 -------------------------RSLVSQLFKRNPRDRPSVNSILE 276 >6E9W-A nrPDB Length = 443 Score = 221 bits (564), Expect = 3e-58, Method: Composition-based stats. Identities = 78/316 (24%), Positives = 126/316 (39%), Gaps = 45/316 (14%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRV-RVQTGEEGMPLSTIREVAVLRHLE 69 + YE V IG GA+G+V R K+ + A+K + + + + E ++ Sbjct: 102 EDYEVVKVIGRGAFGEVQLVRH-KSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFAN 160 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQL 129 + P VV+LF R L +V E++ ++ + VP + + ++ Sbjct: 161 S---PWVVQLFYAFQDDRY-----LYMVMEYMPGG--DLVNLMSNYDVPEKWARFYTAEV 210 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQM--ALTSVVVTLWYRA 187 + LD +HS +HRD+KP N+L+ SG +KLADFG + + + V T Y + Sbjct: 211 VLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYIS 270 Query: 188 PEVLLQSS----YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDW 243 PEVL Y D WSVG EM F S V KI++ + Sbjct: 271 PEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMN---HKNSLTF 327 Query: 244 PRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRI---SAYSALSHPYF 300 P D DI + K+L+ LT + R+ H +F Sbjct: 328 PDD--------------------NDISKEAKNLICAFLT-DREVRLGRNGVEEIKRHLFF 366 Query: 301 QDLERCKENLDSHLPP 316 ++ + E L + P Sbjct: 367 KNDQWAWETLRDTVAP 382 >1NY3-A nrPDB Length = 400 Score = 221 bits (563), Expect = 4e-58, Method: Composition-based stats. Identities = 72/307 (23%), Positives = 126/307 (41%), Gaps = 35/307 (11%) Query: 11 QQYECV-AEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLE 69 Y+ +G G GKV + + + +F ALK + REV + H Sbjct: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKF-ALKML-------QDCPKARREVEL--HWR 110 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQD-LTTYLDKVPEPGVPTETIKDMMFQ 128 + P++VR+ DV R+ L +V E +D L + + + ++M Sbjct: 111 ASQCPHIVRIVDVYENLYAGRKC-LLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKS 169 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTS---SGQIKLADFGLARIYSFQMALTSVVVTLWY 185 + + +LHS + HRD+KP+N+L TS + +KL DFG A+ + +LT+ T +Y Sbjct: 170 IGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYY 229 Query: 186 RAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPR 245 APEVL Y D+WS+G I + P F + GL Sbjct: 230 VAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNH------------GLAISPGMKT 277 Query: 246 DVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLER 305 + + + F + +++ E K L+ L P +R++ ++HP+ + Sbjct: 278 RIRMGQYEFPNPE-------WSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTK 330 Query: 306 CKENLDS 312 + Sbjct: 331 VPQTPLH 337 >2GCD-A nrPDB Length = 309 Score = 221 bits (563), Expect = 4e-58, Method: Composition-based stats. Identities = 75/295 (25%), Positives = 124/295 (42%), Gaps = 40/295 (13%) Query: 9 ADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHL 68 ++ + + EIG G++G V+ ARD++N VA+K++ + I + +R L Sbjct: 13 PEKLFSDLREIGHGSFGAVYFARDVRNS-EVVAIKKMSYSGKQSNEKWQDI--IKEVRFL 69 Query: 69 ETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQ 128 + HPN ++ T LV E+ + L+ V + + I + Sbjct: 70 QKLRHPNTIQYRGCYLREHTA-----WLVMEYCLGSASDLLE-VHKKPLQEVEIAAVTHG 123 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAP 188 L+GL +LHSH ++HRD+K NIL++ G +KL DFG A I + S V T ++ AP Sbjct: 124 ALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAP---ANSFVGTPYWMAP 180 Query: 189 EVLL---QSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPR 245 EV+L + Y VD+WS+G E+ RKP + + L I Sbjct: 181 EVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQ------------ 228 Query: 246 DVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 + E ++ + CL P R ++ L H + Sbjct: 229 -------------NESPALQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFV 270 >2WTK-C nrPDB Length = 305 Score = 220 bits (562), Expect = 5e-58, Method: Composition-based stats. Identities = 80/317 (25%), Positives = 128/317 (40%), Gaps = 40/317 (12%) Query: 12 QYECVAEIGEGAYGKVFKARDLKN-GGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 +Y +GEG+YGKV + D + R V + + + + +E+ +LR L Sbjct: 6 KYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLR- 64 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130 H NV++L DV + + K+ +V E+ + LD VPE P QL+ Sbjct: 65 --HKNVIQLVDVLY---NEEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLI 119 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSF---QMALTSVVVTLWYRA 187 GL++LHS +VH+D+KP N+L+T+ G +K++ G+A + + ++ Sbjct: 120 DGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISALGVAEALHPFAADDTCRTSQGSPAFQP 179 Query: 188 PEVL--LQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPR 245 PE+ L + VD+WS G + F G + I G P Sbjct: 180 PEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGK-----GSYAIPG 234 Query: 246 DVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLER 305 D P DLL L + PAKR S H +F+ Sbjct: 235 DCGPPLS----------------------DLLKGMLEYEPAKRFSIRQIRQHSWFRKKHP 272 Query: 306 CKENLDSHLPPSQNTSE 322 E +PPS +T + Sbjct: 273 PAE-APVPIPPSPDTKD 288 >4WB7-A nrPDB Length = 405 Score = 220 bits (561), Expect = 6e-58, Method: Composition-based stats. Identities = 64/304 (21%), Positives = 120/304 (39%), Gaps = 47/304 (15%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRV-RVQTGEEGMPLSTIREVAVLRHLE 69 Q+E + +G G++G+V + + G A+K + + + + T+ E +L + Sbjct: 96 DQFERIKTLGTGSFGRVMLVKHKETGNH-YAMKILDKQKVVKLKQIEHTLNEKRIL---Q 151 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPGVPTETIKDMMFQ 128 P +V+L + L +V E+V ++ ++L ++ + Q Sbjct: 152 AVNFPFLVKL-----EFSFKDNSNLYMVMEYVPGGEMFSHLRRIGR--FSEPHARFYAAQ 204 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAP 188 ++ ++LHS +++RDLKP+N+L+ G I++ DFG A+ ++ T Y AP Sbjct: 205 IVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK--GRTWTLCGTPEYLAP 262 Query: 189 EVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA 248 E++L Y VD W++G + EM P F + KI+ Sbjct: 263 EIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKV------------ 310 Query: 249 LPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRI-----SAYSALSHPYFQDL 303 +F + KDLL L + KR +H +F Sbjct: 311 ---------------RFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATT 355 Query: 304 ERCK 307 + Sbjct: 356 DWIA 359 >3KA0-A nrPDB Length = 320 Score = 220 bits (561), Expect = 6e-58, Method: Composition-based stats. Identities = 72/307 (23%), Positives = 125/307 (40%), Gaps = 35/307 (11%) Query: 11 QQYECV-AEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLE 69 Y+ +G G GKV + + + +F ALK + REV + H Sbjct: 15 DDYKVTSQVLGLGINGKVLQIFNKRTQEKF-ALKML-------QDCPKARREVEL--HWR 64 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQD-LTTYLDKVPEPGVPTETIKDMMFQ 128 + P++VR+ DV R+ L +V E +D L + + + ++M Sbjct: 65 ASQCPHIVRIVDVYENLYAGRKC-LLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKS 123 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTS---SGQIKLADFGLARIYSFQMALTSVVVTLWY 185 + + +LHS + HRD+KP+N+L TS + +KL DFG A+ + +LT T +Y Sbjct: 124 IGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTEPCYTPYY 183 Query: 186 RAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPR 245 APEVL Y D+WS+G I + P F + GL Sbjct: 184 VAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNH------------GLAISPGMKT 231 Query: 246 DVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLER 305 + + + F + +++ E K L+ L P +R++ ++HP+ + Sbjct: 232 RIRMGQYEFPNPE-------WSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTK 284 Query: 306 CKENLDS 312 + Sbjct: 285 VPQTPLH 291 >2OZA-A nrPDB Length = 356 Score = 220 bits (561), Expect = 7e-58, Method: Composition-based stats. Identities = 72/307 (23%), Positives = 126/307 (41%), Gaps = 35/307 (11%) Query: 11 QQYECV-AEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLE 69 Y+ +G G GKV + + + +F ALK + REV + H Sbjct: 17 DDYKVTSQVLGLGINGKVLQIFNKRTQEKF-ALKML-------QDCPKARREVEL--HWR 66 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQD-LTTYLDKVPEPGVPTETIKDMMFQ 128 + P++VR+ DV R+ L +V E +D L + + + ++M Sbjct: 67 ASQCPHIVRIVDVYENLYAGRKC-LLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKS 125 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTS---SGQIKLADFGLARIYSFQMALTSVVVTLWY 185 + + +LHS + HRD+KP+N+L TS + +KL DFG A+ + +LT+ T +Y Sbjct: 126 IGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYY 185 Query: 186 RAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPR 245 APEVL Y D+WS+G I + P F + GL Sbjct: 186 VAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNH------------GLAISPGMKT 233 Query: 246 DVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLER 305 + + + F + +++ E K L+ L P +R++ ++HP+ + Sbjct: 234 RIRMGQYEFPNPE-------WSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTK 286 Query: 306 CKENLDS 312 + Sbjct: 287 VPQTPLH 293 >5MJB-A nrPDB Length = 305 Score = 220 bits (560), Expect = 8e-58, Method: Composition-based stats. Identities = 67/282 (23%), Positives = 119/282 (42%), Gaps = 24/282 (8%) Query: 14 ECVAEIGEGAYGKVFKARDLKNGGR--FVALKRVRVQTGEEGMPLSTIREVAVLRHLETF 71 + IG G +G+V+K R G R +VA+K ++ E+ + E +++ F Sbjct: 29 KIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEK-QRRDFLSEASIM---GQF 84 Query: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLR 131 +H N++RL V T SR + ++ E ++ + + + M+ + Sbjct: 85 DHRNIIRLEGVVTKSR-----PVMIITEFMENCALDSFLRQNDGQFTVIQLVGMLRGIAA 139 Query: 132 GLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMA---LTSVVV---TLWY 185 G+ +L VHRDL +NILV S+ K++DFGL+R + TS + + + Sbjct: 140 GMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRW 199 Query: 186 RAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILDVIGLPGEEDWP 244 APE + + + D+WS G + E+ + + S+ D + I LP D P Sbjct: 200 TAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCP 259 Query: 245 RDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPA 286 + K +F ++ L K + NPA Sbjct: 260 AALHQLMLDCWQKDRNSRPRFAEIVNT-----LDKMI-RNPA 295 >5SYS-A nrPDB Length = 286 Score = 220 bits (560), Expect = 9e-58, Method: Composition-based stats. Identities = 67/312 (21%), Positives = 124/312 (39%), Gaps = 46/312 (14%) Query: 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR 60 + KD + ++G+G +G+ + NG VA+K ++ T P + ++ Sbjct: 8 LAKDAWEIPRESLRLEVKLGQGCFGECWMGTW--NGTTRVAIKTLKPGTMS---PEAFLQ 62 Query: 61 EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPGVPT 119 E V++ L H +V+L+ V + E + +V E++ L +L + Sbjct: 63 EAQVMKKLR---HEKLVQLYAVVS------EEPIYIVTEYMSKGSLLDFLKGEMGKYLRL 113 Query: 120 ETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSF--QMALT 177 + DM Q+ G+ ++ VHRDL+ NILV + K+ADFGLAR+ A Sbjct: 114 PQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQ 173 Query: 178 SVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILDVIG 236 + + APE L + D+WS G + E+ + + G + + L ++ Sbjct: 174 GAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYR 233 Query: 237 LPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALS 296 +P + P E DL+ +C +P +R + + Sbjct: 234 MPCPPECP--------------------------ESLHDLMCQCWRKDPEERPTFEYLQA 267 Query: 297 HPYFQDLERCKE 308 + +D E Sbjct: 268 --FLEDYFTSTE 277 >6HMD-A nrPDB Length = 365 Score = 219 bits (559), Expect = 1e-57, Method: Composition-based stats. Identities = 85/324 (26%), Positives = 151/324 (46%), Gaps = 33/324 (10%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLE 69 Y+ V ++G G Y +VF+A ++ N R V+ + REV +L +L Sbjct: 52 QDDYQLVRKLGRGKYSEVFEAINITNNERV------VVKILKPVKKKKIKREVKILENLR 105 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQL 129 N+++L D + LVFE+++ L ++ + I+ M++L Sbjct: 106 GGT--NIIKLIDTVKDPVSKTPA---LVFEYINNTDFKQLYQI----LTDFDIRFYMYEL 156 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTS-SGQIKLADFGLARIYSFQMALTSVVVTLWYRAP 188 L+ LD+ HS ++HRD+KP N+++ +++L D+GLA Y V + +++ P Sbjct: 157 LKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGP 216 Query: 189 EVLL-QSSYATPVDLWSVGCIFAEM-FRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRD 246 E+L+ Y +D+WS+GC+ A M FRR+P F G + DQL +I V+G + + Sbjct: 217 ELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKK 276 Query: 247 VALP-----RQAFHSKSAQPIEKFVTD-----IDELGKDLLLKCLTFNPAKRISAYSALS 296 + S + E F+ + DLL K L ++ +R++A A+ Sbjct: 277 YHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAME 336 Query: 297 HPYFQDLERCKENLDSHLPPSQNT 320 HPYF + + + P + N Sbjct: 337 HPYFYPVVK-----EQSQPSADNA 355 >4XEY-B nrPDB Length = 408 Score = 219 bits (559), Expect = 1e-57, Method: Composition-based stats. Identities = 66/295 (22%), Positives = 115/295 (38%), Gaps = 42/295 (14%) Query: 4 DGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVA 63 D ++G G YG+V++ K VA+K ++ T E ++E A Sbjct: 118 DKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLT-VAVKTLKEDTME---VEEFLKEAA 173 Query: 64 VLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPGVPTETI 122 V++ ++ HPN+V+L VCT RE ++ E + +L YL + V + Sbjct: 174 VMKEIK---HPNLVQLLGVCT-----REPPFYIITEFMTYGNLLDYLRECNRQEVNAVVL 225 Query: 123 KDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY--SFQMALTSVV 180 M Q+ +++L +HRDL +N LV + +K+ADFGL+R+ A Sbjct: 226 LYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAK 285 Query: 181 VTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILDVIGLPG 239 + + APE L + ++ D+W+ G + E+ + G + + Sbjct: 286 FPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMER 345 Query: 240 EEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSA 294 E P V +L+ C +NP+ R S Sbjct: 346 PEGCPEKV--------------------------YELMRACWQWNPSDRPSFAEI 374 >6BDL-A nrPDB Length = 347 Score = 219 bits (559), Expect = 1e-57, Method: Composition-based stats. Identities = 64/313 (20%), Positives = 117/313 (37%), Gaps = 42/313 (13%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR-EVAVLRHLE 69 + + +G G +G+V + + A+K ++ + + IR E ++ + Sbjct: 34 SDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIM---Q 90 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFE-HVDQDLTTYLDKVPEPGVPTETIKDMMFQ 128 +VRL+ S+ L ++ E + +L T L T + Sbjct: 91 GAHSDFIVRLYRTFKDSKY-----LYMLMEACLGGELWTILRD--RGSFEDSTTRFYTAC 143 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAP 188 ++ +LHS +++RDLKP+N+++ G KL DFG A+ F + T Y AP Sbjct: 144 VVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAP 203 Query: 189 EVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA 248 E++L + D WS+G + E+ P F G + IL I + Sbjct: 204 EIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMI---------- 253 Query: 249 LPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRI-----SAYSALSHPYFQDL 303 +F I + +L+ K NP++R+ H +F+ Sbjct: 254 ---------------EFPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGF 298 Query: 304 ERCKENLDSHLPP 316 + PP Sbjct: 299 NWEGLRKGTLTPP 311 >3KN6-A nrPDB Length = 325 Score = 219 bits (559), Expect = 1e-57, Method: Composition-based stats. Identities = 79/324 (24%), Positives = 133/324 (41%), Gaps = 45/324 (13%) Query: 11 QQYECV---AEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRH 67 Q Y+ +GEG++ K K+ F A+K + + M +T +E+ L+ Sbjct: 8 QHYDLDLKDKPLGEGSFSICRKCVHKKSNQAF-AVKIIS-----KRMEANTQKEITALKL 61 Query: 68 LETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQD-LTTYLDKVPEPGVPTETIKDMM 126 E HPN+V+L +V + LV E ++ L + K +M Sbjct: 62 CEG--HPNIVKLHEVF-----HDQLHTFLVMELLNGGELFERIKKKKH--FSETEASYIM 112 Query: 127 FQLLRGLDFLHSHRVVHRDLKPQNILVTSSG---QIKLADFGLARIYSFQ-MALTSVVVT 182 +L+ + +H VVHRDLKP+N+L T +IK+ DFG AR+ L + T Sbjct: 113 RKLVSAVSHMHDVGVVHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFT 172 Query: 183 LWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEED 242 L Y APE+L Q+ Y DLWS+G I M + F+ ++++ + D Sbjct: 173 LHYAAPELLNQNGYDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGD 232 Query: 243 WPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQD 302 + + + ++ + KDL+ LT +P KR+ + + QD Sbjct: 233 FSFE----------------GEAWKNVSQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQD 276 Query: 303 LERCKENLDSHLPPSQNTSELNTA 326 + N P L ++ Sbjct: 277 GSQLSSN------PLMTPDILGSS 294 >3DB8-A nrPDB Length = 317 Score = 219 bits (559), Expect = 1e-57, Method: Composition-based stats. Identities = 69/297 (23%), Positives = 122/297 (41%), Gaps = 39/297 (13%) Query: 8 RADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRV-RVQTGEEGMPLSTIREVAVLR 66 R ++Y +G+G + K ++ D+ + A K V + + E+A+ + Sbjct: 39 RTMKRYMRGRFLGKGGFAKCYEITDM-DTKEVFAGKVVPKSMLLKPHQKEKMSTEIAIHK 97 Query: 67 HLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMM 126 L ++P+VV + + + +V E + L K V + M Sbjct: 98 SL---DNPHVVGFHGFF-----EDDDFVYVVLEICRRRSLLELHKR-RKAVTEPEARYFM 148 Query: 127 FQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALT-SVVVTLWY 185 Q ++G+ +LH++RV+HRDLK N+ + +K+ DFGLA F + T Y Sbjct: 149 RQTIQGVQYLHNNRVIHRDLKLGNLFLNDDMDVKIGDFGLATKIEFDGERKKDLCGTPNY 208 Query: 186 RAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPR 245 APEVL + ++ VD+WS+GCI + KP F S + +I Sbjct: 209 IAPEVLCKKGHSFEVDIWSLGCILYTLLVGKPPFETSCLKETYIRIKK-----------N 257 Query: 246 DVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQD 302 + ++PR I+ + L+ + L +P R S L+ +F Sbjct: 258 EYSVPR----------------HINPVASALIRRMLHADPTLRPSVAELLTDEFFTS 298 >2FO0-A nrPDB Length = 495 Score = 219 bits (558), Expect = 1e-57, Method: Composition-based stats. Identities = 65/295 (22%), Positives = 115/295 (38%), Gaps = 42/295 (14%) Query: 4 DGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVA 63 D ++G G YG+V++ K VA+K ++ T E ++E A Sbjct: 210 DKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLT-VAVKTLKEDTME---VEEFLKEAA 265 Query: 64 VLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPGVPTETI 122 V++ ++ HPN+V+L VCT RE ++ E + +L YL + V + Sbjct: 266 VMKEIK---HPNLVQLLGVCT-----REPPFYIITEFMTYGNLLDYLRECNRQEVNAVVL 317 Query: 123 KDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY--SFQMALTSVV 180 M Q+ +++L +HR+L +N LV + +K+ADFGL+R+ A Sbjct: 318 LYMATQISSAMEYLEKKNFIHRNLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAK 377 Query: 181 VTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILDVIGLPG 239 + + APE L + ++ D+W+ G + E+ + G + + Sbjct: 378 FPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMER 437 Query: 240 EEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSA 294 E P V +L+ C +NP+ R S Sbjct: 438 PEGCPEKV--------------------------YELMRACWQWNPSDRPSFAEI 466 >3HKO-A nrPDB Length = 345 Score = 219 bits (558), Expect = 1e-57, Method: Composition-based stats. Identities = 77/347 (22%), Positives = 127/347 (36%), Gaps = 77/347 (22%) Query: 5 GLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAV 64 L ++Y IG+G+YG V A + + A+K + + P R Sbjct: 20 SLLELQKKYHLKGAIGQGSYGVVRVAIENQTRAIR-AIKIMNKNKIRQINPKDVERIKTE 78 Query: 65 LRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQD-----LTTYLDKVPEP---- 115 +R ++ HPN+ RL++V + E + LV E L ++D Sbjct: 79 VRLMKKLHHPNIARLYEVY-----EDEQYICLVMELCHGGHLLDKLNVFIDDSTGKCAMD 133 Query: 116 ------------------------------GVPTETIKDMMFQLLRGLDFLHSHRVVHRD 145 + I ++M Q+ L +LH+ + HRD Sbjct: 134 VVKTQICPCPECNEEAINGSIHGFRESLDFVQREKLISNIMRQIFSALHYLHNQGICHRD 193 Query: 146 LKPQNILVTSSG--QIKLADFGLARIY-----SFQMALTSVVVTLWYRAPEVLL--QSSY 196 +KP+N L +++ +IKL DFGL++ + +T+ T ++ APEVL SY Sbjct: 194 IKPENFLFSTNKSFEIKLVDFGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEVLNTTNESY 253 Query: 197 ATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHS 256 D WS G + + F G +D D + ++L+ Sbjct: 254 GPKCDAWSAGVLLHLLLMGAVPFPGVNDADTISQVLN----------------------- 290 Query: 257 KSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDL 303 K + L +DLL L N +R A AL HP+ Sbjct: 291 KKLCFENPNYNVLSPLARDLLSNLLNRNVDERFDAMRALQHPWISQF 337 >4CRL-A nrPDB Length = 406 Score = 219 bits (558), Expect = 1e-57, Method: Composition-based stats. Identities = 107/332 (32%), Positives = 169/332 (50%), Gaps = 48/332 (14%) Query: 7 CRADQQYEC-VAEIGEGAYGKVFKARDLKNGGRF-VALKRVRVQTGEEGMPLSTIREVAV 64 R + +E ++G G YG V+KA+ ALK++ G+ +S RE+A+ Sbjct: 17 ERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQI----EGTGISMSACREIAL 72 Query: 65 LRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLD-------KVPEPGV 117 LR L+ HPNV+ L V + + K+ L+F++ + DL + + Sbjct: 73 LRELK---HPNVISLQKVFL---SHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQL 126 Query: 118 PTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVT----SSGQIKLADFGLARIYSFQ 173 P +K +++Q+L G+ +LH++ V+HRDLKP NILV G++K+AD G AR+++ Sbjct: 127 PRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSP 186 Query: 174 MA----LTSVVVTLWYRAPEVLLQ-SSYATPVDLWSVGCIFAEMFRRKPLFRGSSD---- 224 + L VVVT WYRAPE+LL Y +D+W++GCIFAE+ +P+F + Sbjct: 187 LKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKT 246 Query: 225 -----VDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKS-----------AQPIEKFVTD 268 DQL +I +V+G P ++DW +P + K + +EK Sbjct: 247 SNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVK 306 Query: 269 IDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 D LL K LT +P KRI++ A+ PYF Sbjct: 307 PDSKAFHLLQKLLTMDPIKRITSEQAMQDPYF 338 >2J0K-A nrPDB Length = 656 Score = 219 bits (557), Expect = 2e-57, Method: Composition-based stats. Identities = 65/294 (22%), Positives = 122/294 (41%), Gaps = 43/294 (14%) Query: 7 CRADQQYECVAEIGEGAYGKVFKARDL--KNGGRFVALKRVRVQTGEEGMPLSTIREVAV 64 ++ E IGEG +G V + + +N VA+K + + + ++E Sbjct: 386 EIQRERIELGRCIGEGQFGDVHQGIYMSPENPAMAVAIKTCK-NCTSDSVREKFLQEALT 444 Query: 65 LRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPGVPTETIK 123 +R F+HP++V+L V T E + ++ E +L ++L +V + + ++ Sbjct: 445 MRQ---FDHPHIVKLIGVIT------ENPVWIIMELCTLGELRSFL-QVRKFSLDLASLI 494 Query: 124 DMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVV-- 181 +QL L +L S R VHRD+ +N+LV+++ +KL DFGL+R + Sbjct: 495 LYAYQLSTALAYLESKRFVHRDIAARNVLVSATDCVKLGDFGLSRYMEDSTYYKASKGKL 554 Query: 182 TLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILDVIGLPGE 240 + + APE + + + D+W G E+ F+G + D +G+I + LP Sbjct: 555 PIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMP 614 Query: 241 EDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSA 294 + P L+ KC ++P++R Sbjct: 615 PNCP--------------------------PTLYSLMTKCWAYDPSRRPRFTEL 642 >3TKU-A nrPDB Length = 433 Score = 219 bits (557), Expect = 2e-57, Method: Composition-based stats. Identities = 79/318 (24%), Positives = 128/318 (40%), Gaps = 45/318 (14%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLE 69 + +E + IG GA+G+V +KN R A+K + + + RE L Sbjct: 89 REDFEIIKVIGRGAFGEV-AVVKMKNTERIYAMKILNKWEMLKRAETACFREER--DVLV 145 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEH-VDQDLTTYLDKVPEPGVPTETIKDMMFQ 128 + + L E L LV ++ V DL T L K E +P + + + + Sbjct: 146 NGDCQWITALHYAF-----QDENHLYLVMDYYVGGDLLTLLSKF-EDKLPEDMARFYIGE 199 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTS--VVVTLWYR 186 ++ +D +H VHRD+KP N+L+ +G I+LADFG + + S V T Y Sbjct: 200 MVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYI 259 Query: 187 APEVLLQ-----SSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEE 241 +PE+L Y D WS+G EM + F S V+ GKI++ Sbjct: 260 SPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMN-------- 311 Query: 242 DWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRI---SAYSALSHP 298 + VTD+ E KDL+ + + + +R+ H Sbjct: 312 --------------HEERFQFPSHVTDVSEEAKDLIQRLIC-SRERRLGQNGIEDFKKHA 356 Query: 299 YFQDLERCKENLDSHLPP 316 +F+ L EN+ + P Sbjct: 357 FFEGL--NWENIRNLEAP 372 >6EII-A nrPDB Length = 352 Score = 219 bits (557), Expect = 2e-57, Method: Composition-based stats. Identities = 83/304 (27%), Positives = 144/304 (47%), Gaps = 28/304 (9%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLE 69 Y+ V ++G G Y +VF+A ++ N + V+ + RE+ +L +L Sbjct: 59 QDDYQLVRKLGRGKYSEVFEAINITNNEKV------VVKILKPVKKKKIKREIKILENLR 112 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQL 129 PN++ L D+ + LVFEHV+ L + + I+ M+++ Sbjct: 113 GG--PNIITLADIVKDPVSRTPA---LVFEHVNNTDFKQLYQ----TLTDYDIRFYMYEI 163 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQ-IKLADFGLARIYSFQMALTSVVVTLWYRAP 188 L+ LD+ HS ++HRD+KP N+++ + ++L D+GLA Y V + +++ P Sbjct: 164 LKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGP 223 Query: 189 EVLL-QSSYATPVDLWSVGCIFAEM-FRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRD 246 E+L+ Y +D+WS+GC+ A M FR++P F G + DQL +I V+G D+ Sbjct: 224 ELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDK 283 Query: 247 VALP-----RQAFHSKSAQPIEKFVTD-----IDELGKDLLLKCLTFNPAKRISAYSALS 296 + S + E+FV + D L K L ++ R++A A+ Sbjct: 284 YNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAME 343 Query: 297 HPYF 300 HPYF Sbjct: 344 HPYF 347 >4C0T-A nrPDB Length = 974 Score = 218 bits (556), Expect = 2e-57, Method: Composition-based stats. Identities = 72/318 (22%), Positives = 129/318 (40%), Gaps = 50/318 (15%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR-EVAVLRHLET 70 ++ E+GEG+Y V A D G + A+K + + + + + E L L Sbjct: 267 DFKFGKELGEGSYSTVILATDKITGKQ-YAVKVLDKRHIIKEKKVKYVNIEKHALNRLSN 325 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPGVPTETIKDMMFQL 129 RL + + L V ++ + +L T + + + E + Q+ Sbjct: 326 -------RLGVISLYFTFQDKDSLYFVLDYASNGELLTLIKRYN--TLNEECTRHFGAQI 376 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARI----------YSFQMALTSV 179 L + ++H + V+HRDLKP+NIL+ +I++ DFG AR+ Y + S Sbjct: 377 LDAIKYMHDNGVIHRDLKPENILLDDKMRIQITDFGTARLLEKKNDESEEYPVDVRAKSF 436 Query: 180 VVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPG 239 V T Y +PE+L P D+W+ GCI +M KP F+ +++ KI + Sbjct: 437 VGTAEYVSPELLENKYCGKPGDVWAFGCIIYQMIAGKPPFKATNEYLTFQKITKLQF--- 493 Query: 240 EEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPY 299 F + +DL+ K L P++R + H + Sbjct: 494 ------------------------AFSAGFPTIIRDLIKKILVLQPSRRATIPEIQKHYF 529 Query: 300 FQDLE-RCKENLDSHLPP 316 FQ ++ + +++ PP Sbjct: 530 FQSVDFKDFDSIWLSDPP 547 >4YNZ-A nrPDB Length = 342 Score = 218 bits (556), Expect = 2e-57, Method: Composition-based stats. Identities = 73/297 (24%), Positives = 119/297 (40%), Gaps = 40/297 (13%) Query: 5 GLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAV 64 G + Y +G+G G V + VA+K V + E + + RE+A+ Sbjct: 4 GSMQYVGPYRLEKTLGKGQTGLVKLGIHCVTCQK-VAIKIVNREKLSESVLMKVEREIAI 62 Query: 65 LRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQD-LTTYLDKVPEPGVPTETIK 123 L+ + EHP+V++L DV + + L LV EHV L YL V + + + + Sbjct: 63 LKLI---EHPHVLKLHDVY-----ENKKYLYLVLEHVSGGELFDYL--VKKGRLTPKEAR 112 Query: 124 DMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTL 183 Q++ LDF HSH + HRDLKP+N+L+ I++ADFG+A + L + + Sbjct: 113 KFFRQIISALDFCHSHSICHRDLKPENLLLDERNNIRIADFGMASLQVGDSLLETSCGSP 172 Query: 184 WYRAPEVLLQSSYA-TPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEED 242 Y PEV+ Y D+WS G I + F + L K+ + Sbjct: 173 HYACPEVIRGEKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVF------ 226 Query: 243 WPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPY 299 I + LL + + A+R++ H + Sbjct: 227 ---------------------HMPHFIPPDCQSLLRGMIEVDAARRLTLEHIQKHIW 262 >4AW2-A nrPDB Length = 437 Score = 218 bits (555), Expect = 3e-57, Method: Composition-based stats. Identities = 79/308 (25%), Positives = 126/308 (40%), Gaps = 43/308 (13%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLE 69 + +E + IG GA+G+V LKN + A+K + + + RE L Sbjct: 73 REDFEILKVIGRGAFGEV-AVVKLKNADKVFAMKILNKWEMLKRAETACFREER--DVLV 129 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEH-VDQDLTTYLDKVPEPGVPTETIKDMMFQ 128 + + L + L LV ++ V DL T L K E +P E + + + Sbjct: 130 NGDSKWITTLHYAF-----QDDNNLYLVMDYYVGGDLLTLLSKF-EDRLPEEMARFYLAE 183 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLA-RIYSFQMALTSV-VVTLWYR 186 ++ +D +H VHRD+KP NIL+ +G I+LADFG ++ +SV V T Y Sbjct: 184 MVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYI 243 Query: 187 APEVLL-----QSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEE 241 +PE+L + Y D WS+G EM + F S V+ GKI++ Sbjct: 244 SPEILQAMEGGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMN-------- 295 Query: 242 DWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRI---SAYSALSHP 298 K VTD+ E KDL+ + + + R+ HP Sbjct: 296 --------------HKERFQFPTQVTDVSENAKDLIRRLIC-SREHRLGQNGIEDFKKHP 340 Query: 299 YFQDLERC 306 +F ++ Sbjct: 341 FFSGIDWD 348 >6CMJ-A nrPDB Length = 321 Score = 218 bits (555), Expect = 3e-57, Method: Composition-based stats. Identities = 82/309 (26%), Positives = 134/309 (43%), Gaps = 51/309 (16%) Query: 7 CRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQT---------GEEGMPLS 57 C QY EIG+G+YG V A + +N + A+K + + G Sbjct: 30 CVQLDQYTLKDEIGKGSYGVVKLAYN-ENDNTYYAMKVLSKKKLIRQAGGCIQPRGPIEQ 88 Query: 58 TIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGV 117 +E+A+L+ L +HPNVV+L +V E L +VFE V+Q ++ + Sbjct: 89 VYQEIAILKKL---DHPNVVKLVEVL---DDPNEDHLYMVFELVNQG--PVMEVPTLKPL 140 Query: 118 PTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMA-L 176 + + L++G+++LH +++HRD+KP N+LV G IK+ADFG++ + A L Sbjct: 141 SEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALL 200 Query: 177 TSVVVTLWYRAPEVLLQSS---YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILD 233 ++ V T + APE L ++ +D+W++G + F +I+ Sbjct: 201 SNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDE-------RIM- 252 Query: 234 VIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFV--TDIDELGKDLLLKCLTFNPAKRISA 291 HSK +F DI E KDL+ + L NP RI Sbjct: 253 -------------------CLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVV 293 Query: 292 YSALSHPYF 300 HP+ Sbjct: 294 PEIKLHPWV 302 >3PFQ-A nrPDB Length = 674 Score = 217 bits (554), Expect = 4e-57, Method: Composition-based stats. Identities = 63/313 (20%), Positives = 119/313 (38%), Gaps = 45/313 (14%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTG-EEGMPLSTIREVAVLRHLET 70 + + +G+G++GKV + + K A+K ++ ++ T+ E VL Sbjct: 342 DFNFLMVLGKGSFGKVMLS-ERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLAL--P 398 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQL 129 + P + +L +L V E+V+ DL ++ +V ++ Sbjct: 399 GKPPFLTQLHSCFQTM-----DRLYFVMEYVNGGDLMYHIQQVGR--FKEPHAVFYAAEI 451 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARI-YSFQMALTSVVVTLWYRAP 188 GL FL S +++RDLK N+++ S G IK+ADFG+ + + + T Y AP Sbjct: 452 AIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAP 511 Query: 189 EVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA 248 E++ Y VD W+ G + EM + F G + + I++ Sbjct: 512 EIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNV------------ 559 Query: 249 LPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISA-----YSALSHPYFQDL 303 + + + + +T +P KR+ H +F+ + Sbjct: 560 ---------------AYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYI 604 Query: 304 ERCKENLDSHLPP 316 + K PP Sbjct: 605 DWEKLERKEIQPP 617 >5L6P-A nrPDB Length = 298 Score = 217 bits (553), Expect = 5e-57, Method: Composition-based stats. Identities = 69/282 (24%), Positives = 121/282 (42%), Gaps = 24/282 (8%) Query: 14 ECVAEIGEGAYGKVFKARDLKNGGR--FVALKRVRVQTGEEGMPLSTIREVAVLRHLETF 71 + IG G +G+V + R + G R FVA+K ++V E + E +++ F Sbjct: 22 KIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYT-ERQRRDFLSEASIM---GQF 77 Query: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLR 131 +HPN++RL V T SR + ++ E ++ ++ + + M+ + Sbjct: 78 DHPNIIRLEGVVTKSR-----PVMILTEFMENCALDSFLRLNDGQFTVIQLVGMLRGIAA 132 Query: 132 GLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMA---LTSVVV---TLWY 185 G+ +L VHRDL +NILV S+ K++DFGL+R + TS + + + Sbjct: 133 GMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRW 192 Query: 186 RAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILDVIGLPGEEDWP 244 APE + + + D+WS G + E+ + + S+ D + + LP D P Sbjct: 193 TAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVEQDYRLPPPMDCP 252 Query: 245 RDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPA 286 + + KF ++ L K L NPA Sbjct: 253 TALHQLMLDCWVRDRNLRPKFSQIVNTLDK------LIRNPA 288 >6NPU-A nrPDB Length = 298 Score = 217 bits (553), Expect = 6e-57, Method: Composition-based stats. Identities = 66/295 (22%), Positives = 115/295 (38%), Gaps = 42/295 (14%) Query: 4 DGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVA 63 D ++G G YG+V++ K VA+K ++ T E ++E A Sbjct: 19 DKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLT-VAVKTLKEDTME---VEEFLKEAA 74 Query: 64 VLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPGVPTETI 122 V++ ++ HPN+V+L VCT RE ++ E + +L YL + V + Sbjct: 75 VMKEIK---HPNLVQLLGVCT-----REPPFYIITEFMTYGNLLDYLRECNRQEVNAVVL 126 Query: 123 KDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY--SFQMALTSVV 180 M Q+ +++L +HRDL +N LV + +K+ADFGL+R+ A Sbjct: 127 LYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAK 186 Query: 181 VTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILDVIGLPG 239 + + APE L + ++ D+W+ G + E+ + G + + Sbjct: 187 FPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMER 246 Query: 240 EEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSA 294 E P V +L+ C +NP+ R S Sbjct: 247 PEGCPEKV--------------------------YELMRACWQWNPSDRPSFAEI 275 >3DKO-A nrPDB Length = 318 Score = 217 bits (552), Expect = 7e-57, Method: Composition-based stats. Identities = 72/292 (24%), Positives = 118/292 (40%), Gaps = 27/292 (9%) Query: 2 EKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVA--LKRVRVQTGEEGMPLSTI 59 E D C + IG G +G+V R G R VA +K ++V E+ + Sbjct: 39 ELDASCI-----KIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEK-QRRDFL 92 Query: 60 REVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPT 119 E +++ F+HPNVV L V T R + +V E ++ + + Sbjct: 93 CEASIM---GQFDHPNVVHLEGVVT-----RGKPVMIVIEFMENGALDAFLRKHDGQFTV 144 Query: 120 ETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQ----MA 175 + M+ + G+ +L VHRDL +NILV S+ K++DFGL+R+ Sbjct: 145 IQLVGMLRGIAAGMRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYT 204 Query: 176 LTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILDV 234 T + + + APE + + + D+WS G + E+ + + S+ D + I + Sbjct: 205 TTGGKIPVRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEG 264 Query: 235 IGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPA 286 LP D P + K KF E +L K + NP Sbjct: 265 YRLPAPMDCPAGLHQLMLDCWQKERAERPKF-----EQIVGILDKMI-RNPN 310 >4TNB-A nrPDB Length = 590 Score = 217 bits (552), Expect = 8e-57, Method: Composition-based stats. Identities = 74/311 (23%), Positives = 126/311 (40%), Gaps = 39/311 (12%) Query: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLS-TIREVAVLRHLETF 71 + +G+G +G+V + ++ G+ A KR+ + ++ S + E +L + + Sbjct: 186 FRQYRVLGKGGFGEVCACQ-VRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQ 244 Query: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQLL 130 VV L + + L LV ++ DL ++ + PG E ++L Sbjct: 245 ---FVVNL-----AYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEIL 296 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEV 190 GL+ LH V+RDLKP+NIL+ G I+++D GLA + V T+ Y APEV Sbjct: 297 CGLEDLHHENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEV 356 Query: 191 LLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALP 250 L Y D W +GC+ EM + FRG R + Sbjct: 357 LNNQRYGLSPDYWGLGCLIYEMIEGQSPFRG-----------------------RKEKVK 393 Query: 251 RQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRIS-----AYSALSHPYFQDLER 305 R+ + + E + E K + LT + +R+ A HP+F+++ Sbjct: 394 REEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEEAAEVKRHPFFRNMNF 453 Query: 306 CKENLDSHLPP 316 + PP Sbjct: 454 KRLEAGMLDPP 464 >4P5Q-A nrPDB Length = 361 Score = 216 bits (551), Expect = 1e-56, Method: Composition-based stats. Identities = 61/278 (21%), Positives = 114/278 (41%), Gaps = 22/278 (7%) Query: 15 CVAEIGEGAYGKVFKARDLKNGGRF--VALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 +G G +G+V R + VA+K ++V E+ + E +++ F+ Sbjct: 37 IDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEK-QRRDFLGEASIM---GQFD 92 Query: 73 HPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRG 132 HPN++RL V T S+ + +V E+++ + + + M+ + G Sbjct: 93 HPNIIRLEGVVTKSK-----PVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASG 147 Query: 133 LDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQ----MALTSVVVTLWYRAP 188 + +L VHRDL +NIL+ S+ K++DFGL+R+ + + + +P Sbjct: 148 MKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSP 207 Query: 189 EVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDV 247 E + + + D+WS G + E+ + + S+ D + + + LP D P + Sbjct: 208 EAIAYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCPAAL 267 Query: 248 ALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNP 285 K KF + L K L NP Sbjct: 268 YQLMLDCWQKDRNNRPKFEQIVSILDK------LIRNP 299 >2I0E-A nrPDB Length = 353 Score = 215 bits (548), Expect = 2e-56, Method: Composition-based stats. Identities = 63/313 (20%), Positives = 119/313 (38%), Gaps = 45/313 (14%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTG-EEGMPLSTIREVAVLRHLET 70 + + +G+G++GKV + + K A+K ++ ++ T+ E VL Sbjct: 21 DFNFLMVLGKGSFGKVMLS-ERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLAL--P 77 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQL 129 + P + +L +L V E+V+ DL ++ +V ++ Sbjct: 78 GKPPFLTQLHSCFQTM-----DRLYFVMEYVNGGDLMYHIQQVGR--FKEPHAVFYAAEI 130 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARI-YSFQMALTSVVVTLWYRAP 188 GL FL S +++RDLK N+++ S G IK+ADFG+ + + + T Y AP Sbjct: 131 AIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAP 190 Query: 189 EVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA 248 E++ Y VD W+ G + EM + F G + + I++ Sbjct: 191 EIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNV------------ 238 Query: 249 LPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISA-----YSALSHPYFQDL 303 + + + + +T +P KR+ H +F+ + Sbjct: 239 ---------------AYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYI 283 Query: 304 ERCKENLDSHLPP 316 + K PP Sbjct: 284 DWEKLERKEIQPP 296 >2WQN-A nrPDB Length = 310 Score = 215 bits (548), Expect = 2e-56, Method: Composition-based stats. Identities = 77/287 (26%), Positives = 129/287 (44%), Gaps = 41/287 (14%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRV-QTGEEGMPLSTIREVAVLRHLET 70 + +IG G + +V++A L + G VALK+V++ + I+E+ +L+ L Sbjct: 33 NFRIEKKIGRGQFSEVYRAACLLD-GVPVALKKVQIFDLMDAKARADCIKEIDLLKQL-- 89 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPG--VPTETIKDMMF 127 HPNV++ + + +L +V E D DL+ + + +P T+ Sbjct: 90 -NHPNVIKYYASFI-----EDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFV 143 Query: 128 QLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQ-MALTSVVVTLWYR 186 QL L+ +HS RV+HRD+KP N+ +T++G +KL D GL R +S + A S+V T +Y Sbjct: 144 QLCSALEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYM 203 Query: 187 APEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGS--SDVDQLGKILDVIGLPGEEDWP 244 +PE + ++ Y D+WS+GC+ EM + F G + KI P D Sbjct: 204 SPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSD-- 261 Query: 245 RDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISA 291 E + L+ C+ +P KR Sbjct: 262 -----------------------HYSEELRQLVNMCINPDPEKRPDV 285 >2XYN-A nrPDB Length = 292 Score = 215 bits (548), Expect = 2e-56, Method: Composition-based stats. Identities = 65/294 (22%), Positives = 115/294 (39%), Gaps = 42/294 (14%) Query: 4 DGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVA 63 D ++G G YG+V+ K VA+K ++ T E ++E A Sbjct: 25 DKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLT-VAVKTLKEDTME---VEEFLKEAA 80 Query: 64 VLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPGVPTETI 122 V++ ++ HPN+V+L VCT+ E +V E++ +L YL + V + Sbjct: 81 VMKEIK---HPNLVQLLGVCTL-----EPPFYIVTEYMPYGNLLDYLRECNREEVTAVVL 132 Query: 123 KDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY--SFQMALTSVV 180 M Q+ +++L +HRDL +N LV + +K+ADFGL+R+ A Sbjct: 133 LYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAK 192 Query: 181 VTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILDVIGLPG 239 + + APE L ++++ D+W+ G + E+ + G + + Sbjct: 193 FPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQ 252 Query: 240 EEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYS 293 E P +L+ C ++PA R S Sbjct: 253 PEGCP--------------------------PKVYELMRACWKWSPADRPSFAE 280 >1JPA-A nrPDB Length = 312 Score = 215 bits (547), Expect = 2e-56, Method: Composition-based stats. Identities = 66/282 (23%), Positives = 115/282 (40%), Gaps = 24/282 (8%) Query: 14 ECVAEIGEGAYGKVFKARDLKNGGR--FVALKRVRVQTGEEGMPLSTIREVAVLRHLETF 71 + IG G +G+V G R FVA+K ++ E+ + E +++ F Sbjct: 36 KIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEK-QRRDFLSEASIM---GQF 91 Query: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLR 131 +HPNV+ L V T S T + ++ E ++ + + + M+ + Sbjct: 92 DHPNVIHLEGVVTKS-----TPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAA 146 Query: 132 GLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMA---LTSVVV---TLWY 185 G+ +L VHRDL +NILV S+ K++DFGL+R + TS + + + Sbjct: 147 GMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRW 206 Query: 186 RAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILDVIGLPGEEDWP 244 APE + + + D+WS G + E+ + + ++ D + I LP D P Sbjct: 207 TAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCP 266 Query: 245 RDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPA 286 + K KF ++ L K + NP Sbjct: 267 SALHQLMLDCWQKDRNHRPKFGQIVNT-----LDKMI-RNPN 302 >4GS6-A nrPDB Length = 315 Score = 215 bits (547), Expect = 3e-56, Method: Composition-based stats. Identities = 81/321 (25%), Positives = 134/321 (41%), Gaps = 55/321 (17%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 ++ E +G GA+G V KA+ + VA+K++ ++ + + LR L Sbjct: 9 KEIEVEEVVGRGAFGVVCKAKWRA---KDVAIKQIESESERKAF-------IVELRQLSR 58 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQD-LTTYLD-KVPEPGVPTETIKDMMFQ 128 HPN+V+L+ C + LV E+ + L L P P Q Sbjct: 59 VNHPNIVKLYGACL-------NPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQ 111 Query: 129 LLRGLDFLHSHR---VVHRDLKPQNILVTSSGQI-KLADFGLARIYSFQMALTSVVVTLW 184 +G+ +LHS + ++HRDLKP N+L+ + G + K+ DFG A Q +T+ + Sbjct: 112 CSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTA--CDIQTHMTNNKGSAA 169 Query: 185 YRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWP 244 + APEV S+Y+ D++S G I E+ R+ F D IG P Sbjct: 170 WMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPF-------------DEIGGPAFRIMW 216 Query: 245 RDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYS---ALSH--PY 299 R +PIE L+ +C + +P++R S ++H Y Sbjct: 217 AVHNGTRPPLIKNLPKPIES-----------LMTRCWSKDPSQRPSMEEIVKIMTHLMRY 265 Query: 300 FQDLERCKENLDSH-LPPSQN 319 F + + H LPP ++ Sbjct: 266 FPGADEPLQYPCQHSLPPGED 286 >5XVU-A nrPDB Length = 332 Score = 215 bits (547), Expect = 3e-56, Method: Composition-based stats. Identities = 85/308 (27%), Positives = 152/308 (49%), Gaps = 28/308 (9%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 +YE + +IG G Y +VF D + R A ++ + RE+ +L++L Sbjct: 31 NRYEIMKKIGRGKYSEVFNGYDTE-CNRPCA-----IKVLKPVKKKKIKREIKILQNLNG 84 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130 PN+++L D+ T + L+FE+++ L P + I+ ++Q+L Sbjct: 85 G--PNIIKLLDIVKDPVTKTPS---LIFEYINNIDFKTL----YPKFTDKDIRYYIYQIL 135 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTSSG-QIKLADFGLARIYSFQMALTSVVVTLWYRAPE 189 + LD+ HS ++HRD+KP NI++ QI+L +GLA Y V + +Y+ PE Sbjct: 136 KALDYCHSQGIMHRDVKPHNIMIDHENRQIRLISWGLAEFYHPGQEYNVRVASRYYKGPE 195 Query: 190 VLLQ-SSYATPVDLWSVGCIFA-EMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDV 247 +L+ Y +D+WS+GC+ A +F+++P F G + DQL KI V+G + + Sbjct: 196 LLIDLQLYDYSLDIWSLGCMLAGMIFKKEPFFCGHDNYDQLVKIAKVLGTEDLHAYLKKY 255 Query: 248 ALPRQAFH-----SKSAQPIEKFVTDID-----ELGKDLLLKCLTFNPAKRISAYSALSH 297 + + + +P F+T + + DL+ K L ++ AKRI+ A+ H Sbjct: 256 NIKLKPHYLNILGEYERKPWSHFLTQSNIDIAKDEVIDLIDKMLIYDHAKRIAPKEAMEH 315 Query: 298 PYFQDLER 305 PYF+++ Sbjct: 316 PYFREVRE 323 >3A4O-X nrPDB Length = 286 Score = 214 bits (546), Expect = 4e-56, Method: Composition-based stats. Identities = 61/268 (22%), Positives = 116/268 (43%), Gaps = 17/268 (6%) Query: 2 EKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIRE 61 +KD + + V +G G +G+V+ + VA+K ++ T + + E Sbjct: 4 DKDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTK--VAVKTLKPGTMS---VQAFLEE 58 Query: 62 VAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPGVPTE 120 +++ L+ H +VRL+ V T RE + ++ E++ L +L V Sbjct: 59 ANLMKTLQ---HDKLVRLYAVVT-----REEPIYIITEYMAKGSLLDFLKSDEGGKVLLP 110 Query: 121 TIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSF--QMALTS 178 + D Q+ G+ ++ +HRDL+ N+LV+ S K+ADFGLAR+ A Sbjct: 111 KLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREG 170 Query: 179 VVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILDVIGL 237 + + APE + + D+WS G + E+ K + G ++ D + + + Sbjct: 171 AKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRM 230 Query: 238 PGEEDWPRDVALPRQAFHSKSAQPIEKF 265 P E+ P ++ + + A+ F Sbjct: 231 PRVENCPDELYDIMKMCWKEKAEERPTF 258 >2R2P-A nrPDB Length = 295 Score = 214 bits (546), Expect = 4e-56, Method: Composition-based stats. Identities = 65/280 (23%), Positives = 116/280 (41%), Gaps = 22/280 (7%) Query: 14 ECVAEIGEGAYGKVFKARDLKNGGRF--VALKRVRVQTGEEGMPLSTIREVAVLRHLETF 71 IG G +G+V R G R VA+K ++V E+ + E +++ F Sbjct: 25 TIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEK-QRRDFLGEASIM---GQF 80 Query: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLR 131 +HPN++ L V T S+ + +V E+++ K + + M+ + Sbjct: 81 DHPNIIHLEGVVTKSK-----PVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGISA 135 Query: 132 GLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQ----MALTSVVVTLWYRA 187 G+ +L VHRDL +NIL+ S+ K++DFGL+R+ + + + A Sbjct: 136 GMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTA 195 Query: 188 PEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILDVIGLPGEEDWPRD 246 PE + + + D+WS G + E+ + + ++ D + + + LP D P Sbjct: 196 PEAIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPAA 255 Query: 247 VALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPA 286 + K KF ++ L K L NPA Sbjct: 256 LYQLMLDCWQKERNSRPKFDEIVNMLDK------LIRNPA 289 >4FR4-A nrPDB Length = 384 Score = 214 bits (545), Expect = 5e-56, Method: Composition-based stats. Identities = 71/310 (22%), Positives = 128/310 (41%), Gaps = 39/310 (12%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTI-REVAVLRHLE 69 +E + IG+G++GKV + + + A+K + Q E + + +E+ ++ + Sbjct: 15 DHFEILRAIGKGSFGKVCIVQ-KNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIM---Q 70 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQL 129 EHP +V L S D E +V + DL +L + ET+K + +L Sbjct: 71 GLEHPFLVNL----WYSFQDEEDMFMVVDLLLGGDLRYHLQQNVH--FKEETVKLFICEL 124 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPE 189 + LD+L + R++HRD+KP NIL+ G + + DF +A + + +T++ T Y APE Sbjct: 125 VMALDYLQNQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQITTMAGTKPYMAPE 184 Query: 190 VL---LQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRD 246 + + Y+ VD WS+G E+ R + + S Sbjct: 185 MFSSRKGAGYSFAVDWWSLGVTAYELLRGRRPYHIRS----------------------- 221 Query: 247 VALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRIS-AYSALSHPYFQDLER 305 + + + + + + LL K L NP +R S + PY D+ Sbjct: 222 -STSSKEIVHTFETTVVTYPSAWSQEMVSLLKKLLEPNPDQRFSQLSDVQNFPYMNDINW 280 Query: 306 CKENLDSHLP 315 +P Sbjct: 281 DAVFQKRLIP 290 >5YV8-A nrPDB Length = 298 Score = 214 bits (544), Expect = 5e-56, Method: Composition-based stats. Identities = 83/326 (25%), Positives = 135/326 (41%), Gaps = 66/326 (20%) Query: 5 GLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQT--------------- 49 G C QY EIG+G+YG V A + +N + A+K + + Sbjct: 7 GDCVQLNQYTLKDEIGKGSYGVVKLAYN-ENDNTYYAMKVLSKKKLIRQAGFPRRPPPRG 65 Query: 50 ---------GEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEH 100 G +E+A+L+ L +HPNVV+L +V E L +VFE Sbjct: 66 TRPAPGGCIQPRGPIEQVYQEIAILKKL---DHPNVVKLVEVL---DDPNEDHLYMVFEL 119 Query: 101 VDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIK 160 V+Q ++ + + + L++G+++LH +++HRD+KP N+LV G IK Sbjct: 120 VNQG--PVMEVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIK 177 Query: 161 LADFGLARIYSFQMA-LTSVVVTLWYRAPEVLLQSS---YATPVDLWSVGCIFAEMFRRK 216 +ADFG++ + A L++ V T + APE L ++ +D+W++G + Sbjct: 178 IADFGVSNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQ 237 Query: 217 PLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFV--TDIDELGK 274 F +I+ HSK +F DI E K Sbjct: 238 CPFMDE-------RIM--------------------CLHSKIKSQALEFPDQPDIAEDLK 270 Query: 275 DLLLKCLTFNPAKRISAYSALSHPYF 300 DL+ + L NP RI HP+ Sbjct: 271 DLITRMLDKNPESRIVVPEIKLHPWV 296 >4E93-A nrPDB Length = 377 Score = 214 bits (544), Expect = 6e-56, Method: Composition-based stats. Identities = 72/303 (23%), Positives = 122/303 (40%), Gaps = 43/303 (14%) Query: 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR 60 + KD + +IG G +G+VF R L+ VA+K R +T + ++ Sbjct: 104 VPKDKWVLNHEDLVLGEQIGRGNFGEVFSGR-LRADNTLVAVKSCR-ETLPPDLKAKFLQ 161 Query: 61 EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTE 120 E +L+ + HPN+VRL VCT ++ + +V E V + + + Sbjct: 162 EARILKQ---YSHPNIVRLIGVCT-----QKQPIYIVMELVQGGDFLTFLRTEGARLRVK 213 Query: 121 TIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTS-- 178 T+ M+ G+++L S +HRDL +N LVT +K++DFG++R + + S Sbjct: 214 TLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGG 273 Query: 179 -VVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILDVIG 236 V + + APE L Y++ D+WS G + E F + S+ + Sbjct: 274 LRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGR 333 Query: 237 LPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRI---SAYS 293 LP E P V L+ +C + P +R + Y Sbjct: 334 LPCPELCPDAVFR--------------------------LMEQCWAYEPGQRPSFSTIYQ 367 Query: 294 ALS 296 L Sbjct: 368 ELQ 370 >2Y6O-A nrPDB Length = 291 Score = 213 bits (543), Expect = 7e-56, Method: Composition-based stats. Identities = 63/284 (22%), Positives = 116/284 (40%), Gaps = 24/284 (8%) Query: 14 ECVAEIGEGAYGKVFKARDLKNGGRF--VALKRVRVQTGEEGMPLSTIREVAVLRHLETF 71 + IG G +G+V R G R VA+K ++ ++ + E +++ F Sbjct: 17 KIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDK-QRRDFLSEASIM---GQF 72 Query: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLR 131 +HPN++ L V T + + ++ E+++ + + + M+ + Sbjct: 73 DHPNIIHLEGVVTKCK-----PVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGS 127 Query: 132 GLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQ----MALTSVVVTLWYRA 187 G+ +L VHRDL +NILV S+ K++DFG++R+ + + + A Sbjct: 128 GMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTA 187 Query: 188 PEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILDVIGLPGEEDWPRD 246 PE + + + D+WS G + E+ + + S+ D + I + LP D P Sbjct: 188 PEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPPMDCPIA 247 Query: 247 VALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPA--KR 288 + K KF ++ L K L NP KR Sbjct: 248 LHQLMLDCWQKERSDRPKFGQIVNMLDK------LIRNPNSLKR 285 >2OU7-A nrPDB Length = 335 Score = 213 bits (543), Expect = 8e-56, Method: Composition-based stats. Identities = 66/286 (23%), Positives = 111/286 (38%), Gaps = 39/286 (13%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRV-RVQTGEEGMPLSTIREVAVLRHLETFEHPNVV 77 +G+G + K F+ D + A K V + + E+++ R L H +VV Sbjct: 49 LGKGGFAKCFEISD-ADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLA---HQHVV 104 Query: 78 RLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLH 137 + + +V E + L K + + + Q++ G +LH Sbjct: 105 GFHGFF-----EDNDFVFVVLELCRRRSLLELHKR-RKALTEPEARYYLRQIVLGCQYLH 158 Query: 138 SHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSV-VVTLWYRAPEVLLQSSY 196 +RV+HRDLK N+ + ++K+ DFGLA + V T Y APEVL + + Sbjct: 159 RNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGH 218 Query: 197 ATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHS 256 + VD+WS+GCI + KP F S + +I E P+ Sbjct: 219 SFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKK-----NEYSIPK----------- 262 Query: 257 KSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQD 302 I+ + L+ K L +P R + L+ +F Sbjct: 263 -----------HINPVAASLIQKMLQTDPTARPTINELLNDEFFTS 297 >6CQF-A nrPDB Length = 297 Score = 213 bits (542), Expect = 9e-56, Method: Composition-based stats. Identities = 75/293 (25%), Positives = 125/293 (42%), Gaps = 38/293 (12%) Query: 9 ADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHL 68 Y+ + +G G YG+VFKARD +G VALK V+++ ++ L +E+ +L+ Sbjct: 14 PRDHYDLLQRLGGGTYGEVFKARDKVSGD-LVALKMVKMEPDDDVSTLQ--KEILILKTC 70 Query: 69 ETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQ 128 H N+V + KL + E + +V + I + + Sbjct: 71 R---HANIVAYHGSYLWLQ-----KLWICMEFCGAGSLQDIYQVT-GSLSELQISYVCRE 121 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALT-SVVVTLWYRA 187 +L+GL +LHS + +HRD+K NIL+ +G+++LADFG++ +A + + T ++ A Sbjct: 122 VLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLAFIGTPYWMA 181 Query: 188 PE---VLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWP 244 PE V L+ Y D+WS+G E+ +P + L + P Sbjct: 182 PEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQP------ 235 Query: 245 RDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSH 297 P K + + LT +P KR SA LSH Sbjct: 236 ----------------PRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSH 272 >2VWV-A nrPDB Length = 302 Score = 213 bits (542), Expect = 1e-55, Method: Composition-based stats. Identities = 67/282 (23%), Positives = 115/282 (40%), Gaps = 24/282 (8%) Query: 14 ECVAEIGEGAYGKVFKARDLKNGGRF--VALKRVRVQTGEEGMPLSTIREVAVLRHLETF 71 + IG G +G+V + R G + VA+K ++ E + E +++ F Sbjct: 19 KIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLK-GGYTERQRREFLSEASIM---GQF 74 Query: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLR 131 EHPN++RL V T S + ++ E ++ ++ + + M+ + Sbjct: 75 EHPNIIRLEGVVTNSM-----PVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIAS 129 Query: 132 GLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY---SFQMALTSVVV---TLWY 185 G+ +L VHRDL +NILV S+ K++DFGL+R S TS + + + Sbjct: 130 GMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTETSSLGGKIPIRW 189 Query: 186 RAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILDVIGLPGEEDWP 244 APE + + + D WS G + E+ + + S+ D + I LP D P Sbjct: 190 TAPEAIAFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCP 249 Query: 245 RDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPA 286 + K +F + L K + NPA Sbjct: 250 TSLHQLMLDCWQKDRNARPRFPQVVSA-----LDKMI-RNPA 285 >5DYK-A nrPDB Length = 853 Score = 212 bits (540), Expect = 2e-55, Method: Composition-based stats. Identities = 78/321 (24%), Positives = 124/321 (38%), Gaps = 48/321 (14%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQT---GEEGMPLSTIREVAVLRH 67 + E IG G +G V K ALK V ++ + + RE+ Sbjct: 539 DELETERIIGRGTFGTVKLV-HHKPTKIRYALKCVSKRSIINLNQQNNIKLEREIT---- 593 Query: 68 LETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPGVPTETIKDMM 126 +HP ++RL S+ + E V +L + K+ + + + Sbjct: 594 -AENDHPFIIRLVRTFKDSKY-----FYFLTELVTGGELYDAIRKLG--LLSKSQAQFYL 645 Query: 127 FQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYR 186 ++ +++LH +V+RDLKP+NIL+ G +KL DFG A+ Q ++V T Y Sbjct: 646 GSIILAIEYLHERNIVYRDLKPENILLDKQGYVKLIDFGCAKKV--QGRAYTLVGTPHYM 703 Query: 187 APEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRD 246 APEV+L Y VD+W++G E F G+ + DQL D++ Sbjct: 704 APEVILGKGYGCTVDIWALGICLYEFICGPLPF-GNDEEDQLEIFRDIL----------- 751 Query: 247 VALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISA-----YSALSHPYFQ 301 +VTD D +L+ + L P RI HP+F Sbjct: 752 ----------TGQLTFPDYVTDTDS--INLMKRLLCRLPQGRIGCSINGFKDIKDHPFFS 799 Query: 302 DLERCKENLDSHLPPSQNTSE 322 + K PP + SE Sbjct: 800 NFNWDKLAGRLLDPPLVSKSE 820 >4J52-A nrPDB Length = 293 Score = 212 bits (540), Expect = 2e-55, Method: Composition-based stats. Identities = 66/286 (23%), Positives = 111/286 (38%), Gaps = 39/286 (13%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRV-RVQTGEEGMPLSTIREVAVLRHLETFEHPNVV 77 +G+G + K F+ D + A K V + + E+++ R L H +VV Sbjct: 22 LGKGGFAKCFEISD-ADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLA---HQHVV 77 Query: 78 RLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLH 137 + + +V E + L K + + + Q++ G +LH Sbjct: 78 GFHGFF-----EDNDFVFVVLELCRRRSLLELHKR-RKALTEPEARYYLRQIVLGCQYLH 131 Query: 138 SHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSV-VVTLWYRAPEVLLQSSY 196 +RV+HRDLK N+ + ++K+ DFGLA + V T Y APEVL + + Sbjct: 132 RNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGH 191 Query: 197 ATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHS 256 + VD+WS+GCI + KP F S + +I E P+ Sbjct: 192 SFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKK-----NEYSIPK----------- 235 Query: 257 KSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQD 302 I+ + L+ K L +P R + L+ +F Sbjct: 236 -----------HINPVAASLIQKMLQTDPTARPTINELLNDEFFTS 270 >2XNP-A nrPDB Length = 279 Score = 212 bits (539), Expect = 2e-55, Method: Composition-based stats. Identities = 79/299 (26%), Positives = 123/299 (41%), Gaps = 42/299 (14%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 + YE + IG G+YG+ K R +G V K + + E + EV +LR L+ Sbjct: 6 EDYEVLYTIGTGSYGRCQKIRRKSDGKILV-WKELDYGSMTEAEKQMLVSEVNLLRELK- 63 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDK--VPEPGVPTETIKDMMF 127 HPN+VR +D T L +V E+ + DL + + K + E + +M Sbjct: 64 --HPNIVRYYDRIIDRTN---TTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMT 118 Query: 128 QLLRGLDFLHS-----HRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMAL-TSVVV 181 QL L H H V+HRDLKP N+ + +KL DFGLARI + + + V Sbjct: 119 QLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVG 178 Query: 182 TLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEE 241 T +Y +PE + + SY D+WS+GC+ E+ P F S + GKI + Sbjct: 179 TPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGK------ 232 Query: 242 DWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 + + +++ + L R S L +P Sbjct: 233 --------------------FRRIPYRYSDELNEIITRMLNLKDYHRPSVEEILENPLI 271 >3ALO-A nrPDB Length = 327 Score = 211 bits (538), Expect = 3e-55, Method: Composition-based stats. Identities = 71/299 (23%), Positives = 123/299 (41%), Gaps = 40/299 (13%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 + + + EIG GAYG V K K G+ +A+KR+R E+ + V+R + Sbjct: 22 EDLKDLGEIGRGAYGSVNKMVH-KPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMR---S 77 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLD---KVPEPGVPTETIKDMMF 127 + P +V+ + RE + E + + V + +P E + + Sbjct: 78 SDCPYIVQFYGALF-----REGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITL 132 Query: 128 QLLRGLDFLHSH-RVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYR 186 ++ L+ L + +++HRD+KP NIL+ SG IKL DFG++ +A T Y Sbjct: 133 ATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYM 192 Query: 187 APEVL----LQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDV-DQLGKILDVIGLPGEE 241 APE + + Y D+WS+G E+ + + + V DQL +++ Sbjct: 193 APERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKG------- 245 Query: 242 DWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 D P+ + F + + CLT + +KR L HP+ Sbjct: 246 DPPQLSNSEEREF---------------SPSFINFVNLCLTKDESKRPKYKELLKHPFI 289 >3PPZ-A nrPDB Length = 309 Score = 211 bits (538), Expect = 3e-55, Method: Composition-based stats. Identities = 75/328 (22%), Positives = 131/328 (39%), Gaps = 50/328 (15%) Query: 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR 60 M+ D + +IG G++G V +A G VA+K + Q +R Sbjct: 27 MDGDDMDIPWCDLNIKEKIGAGSFGTVHRAEWH---GSDVAVKILMEQDFHAERVNEFLR 83 Query: 61 EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVP-EPGVP 118 EVA+++ L HPN+V T + L++V E++ L L K + Sbjct: 84 EVAIMKRLR---HPNIVLFMGAVT-----QPPNLSIVTEYLSRGSLYRLLHKSGAREQLD 135 Query: 119 TETIKDMMFQLLRGLDFLHSHR--VVHRDLKPQNILVTSSGQIKLADFGLARI-YSFQMA 175 M + + +G+++LH+ +VHRDLK N+LV +K+ DFGL+R+ S ++ Sbjct: 136 ERRRLSMAYDVAKGMNYLHNRNPPIVHRDLKSPNLLVDKKYTVKVCDFGLSRLKASTFLS 195 Query: 176 LTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVI 235 S T + APEVL D++S G I E+ + + + + + Sbjct: 196 SKSAAGTPEWMAPEVLRDEPSNEKSDVYSFGVILWELATLQQPWGNLNPAQVVAAV---- 251 Query: 236 GLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSAL 295 F K + +++ ++ C T P KR S + + Sbjct: 252 -----------------GFKCKRLE----IPRNLNPQVAAIIEGCWTNEPWKRPSFATIM 290 Query: 296 SHPYFQDLERCKENLDSHLPPSQNTSEL 323 + + + S +PP N S+L Sbjct: 291 --------DLLRPLIKSAVPP-PNRSDL 309 >5H2U-A nrPDB Length = 267 Score = 211 bits (537), Expect = 4e-55, Method: Composition-based stats. Identities = 64/290 (22%), Positives = 119/290 (41%), Gaps = 41/290 (14%) Query: 6 LCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVL 65 + R +++ ++G G +G+VF+ VA+K + L E+ + Sbjct: 1 MERPREEFTLCRKLGSGYFGEVFEGLWK--DRVQVAIKVISRDNLLHQQMLQ--SEIQAM 56 Query: 66 RHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPGVPTETIKD 124 + L H +++ L+ V +V + ++ E + L L E +P + D Sbjct: 57 KKLR---HKHILALYAVVSVG-----DPVYIITELMAKGSLLELLRDSDEKVLPVSELLD 108 Query: 125 MMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLW 184 + +Q+ G+ +L S +HRDL +NILV + K+ DFGLAR+ + L+ + Sbjct: 109 IAWQVAEGMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPY 168 Query: 185 -YRAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILDVIGLPGEED 242 + APE L + Y+T D+WS G + EMF + + G S+ + ++ +P + Sbjct: 169 KWTAPEALSRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLE 228 Query: 243 WPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAY 292 P L+L C +P +R + Sbjct: 229 CP--------------------------PSVHKLMLTCWCRDPEQRPTFK 252 >5U6B-A nrPDB Length = 307 Score = 210 bits (536), Expect = 5e-55, Method: Composition-based stats. Identities = 65/319 (20%), Positives = 120/319 (37%), Gaps = 49/319 (15%) Query: 15 CVAEIGEGAYGKVFKARDLKNGGRF-VALKRVRVQTGEEGMPLSTIREVAVLRHLETFEH 73 +GEG +G V + + ++ VA+K +++ + E ++ F+H Sbjct: 27 LGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKE---FDH 83 Query: 74 PNVVRLFDVCTV-SRTDRETKLTLVFEHVD-QDLTTYLDKVP----EPGVPTETIKDMMF 127 PNV+RL VC S + ++ + DL ++L +PT+ + M Sbjct: 84 PNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMA 143 Query: 128 QLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY---SFQMALTSVVVTLW 184 + G+++L + R +HRDL +N ++ + + +ADFGL++ + + + Sbjct: 144 DIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVK 203 Query: 185 YRAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILDVIGLPGEEDW 243 + A E L Y + D+WS G E+ + + G + + + L D Sbjct: 204 WIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADC 263 Query: 244 PRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDL 303 + L+ +C NP R S F +L Sbjct: 264 LDGLYA--------------------------LMSRCWELNPQDRPS---------FTEL 288 Query: 304 ERCKENLDSHLPPSQNTSE 322 EN LPP+Q E Sbjct: 289 REDLENTLKALPPAQEPDE 307 >6GQK-A nrPDB Length = 328 Score = 210 bits (535), Expect = 7e-55, Method: Composition-based stats. Identities = 72/332 (21%), Positives = 118/332 (35%), Gaps = 63/332 (18%) Query: 6 LCRADQQYECVAEIGEGAYGKVFKARD----LKNGGRFVALKRVRVQTGEEGMPLSTIRE 61 + +G GA+GKV +A + VA+K ++ + + + E Sbjct: 36 WEFPRNRLSFGKTLGAGAFGKVVEATAQGLIKSDAAMTVAVKMLK-PSAHSTEREALMSE 94 Query: 62 VAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPGVP-- 118 + VL +L H N+V L CT ++ E+ DL +L + + VP Sbjct: 95 LKVLSYLG--NHENIVNLLGACT-----HGGPTLVITEYCCYGDLLNFLRRKRDEFVPYK 147 Query: 119 ------------TETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGL 166 E + +Q+ +G+ FL S +HRDL +NIL+T K+ DFGL Sbjct: 148 VAPEDLYKDFLTLEHLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGNITKICDFGL 207 Query: 167 ARIYSFQMAL---TSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGS 222 AR + + + + APE + S Y D+WS G E+F + G Sbjct: 208 ARDIKNDSNYVDKGNARLPVKWMAPESIFNSVYTFESDVWSYGIFLWELFSLGSSPYPGM 267 Query: 223 S-DVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCL 281 D I + + E P D++ C Sbjct: 268 PVDSKFYKMIKEGFRMSSPEYAP--------------------------AEMYDIMKTCW 301 Query: 282 TFNPAKRISAYSALSHPYFQDLERCKENLDSH 313 +P KR + QD+E+ +H Sbjct: 302 DADPDKRPTFKQI-----VQDIEKQISESTNH 328 >5VO2-A nrPDB Length = 300 Score = 210 bits (535), Expect = 7e-55, Method: Composition-based stats. Identities = 68/296 (22%), Positives = 119/296 (40%), Gaps = 48/296 (16%) Query: 3 KDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREV 62 +D ++ + +G GA G VF R G VA+K+VR ++E Sbjct: 4 EDLWEVPFEEILDLQWVGSGAQGAVFLGRFH---GEEVAVKKVR-----------DLKET 49 Query: 63 AVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETI 122 + +HL +HPN++ VCT + ++ E Q + + P V + Sbjct: 50 DI-KHLRKLKHPNIITFKGVCTQA-----PCYCILMEFCAQGQLYEVLRAGRP-VTPSLL 102 Query: 123 KDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVT 182 D + G+++LH H+++HRDLK N+L+T +K++DFG ++ S + S T Sbjct: 103 VDWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGT 162 Query: 183 LWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKI-LDVIGLPGEE 241 + + APEV+ + VD+WS G + E+ + ++ + + + + LP Sbjct: 163 VAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPS 222 Query: 242 DWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSH 297 P + LL +C P R S L H Sbjct: 223 SCPDGFKI--------------------------LLRQCWNSKPRNRPSFRQILLH 252 >3TT0-A nrPDB Length = 382 Score = 210 bits (534), Expect = 8e-55, Method: Composition-based stats. Identities = 64/316 (20%), Positives = 126/316 (39%), Gaps = 59/316 (18%) Query: 6 LCRADQQYECVAEIGEGAYGKVFKA------RDLKNGGRFVALKRVRVQTGEEGMPLSTI 59 + +GEGA+G+V A +D N VA+K ++ E+ + I Sbjct: 64 WELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLS-DLI 122 Query: 60 REVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLD-------- 110 E+ +++ + +H N++ L CT ++ L ++ E+ +L YL Sbjct: 123 SEMEMMKMIG--KHKNIINLLGACT-----QDGPLYVIVEYASKGNLREYLQARRPPGLE 175 Query: 111 ------KVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADF 164 PE + ++ + +Q+ RG+++L S + +HRDL +N+LVT +K+ADF Sbjct: 176 YSYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADF 235 Query: 165 GLAR---IYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFR 220 GLAR + T+ + + + APE L Y D+WS G + E+F + Sbjct: 236 GLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYP 295 Query: 221 GSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKC 280 G + + + + + ++ + ++ C Sbjct: 296 GVPVEELFKLLKEGHRMDKPSNCTNELYM--------------------------MMRDC 329 Query: 281 LTFNPAKRISAYSALS 296 P++R + + Sbjct: 330 WHAVPSQRPTFKQLVE 345 >5KKR-C nrPDB Length = 395 Score = 209 bits (533), Expect = 1e-54, Method: Composition-based stats. Identities = 78/314 (24%), Positives = 132/314 (42%), Gaps = 32/314 (10%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLE 69 D +E ++E+G G G VFK K G +A K + ++ + + IRE+ VL Sbjct: 67 DDDFEKISELGAGNGGVVFKVSH-KPSGLVMARKLIHLEI-KPAIRNQIIRELQVLHECN 124 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQD-LTTYLDKVPEPGVPTETIKDMMFQ 128 + P +V + + ++++ EH+D L L K +P + + + Sbjct: 125 S---PYIVGFYGAFY-----SDGEISICMEHMDGGSLDQVLKKAGR--IPEQILGKVSIA 174 Query: 129 LLRGLDFL-HSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRA 187 +++GL +L H+++HRD+KP NILV S G+IKL DFG++ MA S V T Y + Sbjct: 175 VIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA-NSFVGTRSYMS 233 Query: 188 PEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKI-LDVIGLPGEEDWPRD 246 PE L + Y+ D+WS+G EM + + V G E Sbjct: 234 PERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPR 293 Query: 247 VALPRQAFHSKSAQPIEKFVTDIDE----------------LGKDLLLKCLTFNPAKRIS 290 + + ++P +D +D + KCL NPA+R Sbjct: 294 TPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFVNKCLIKNPAERAD 353 Query: 291 AYSALSHPYFQDLE 304 + H + + + Sbjct: 354 LKQLMVHAFIKRSD 367 >2HK5-A nrPDB Length = 270 Score = 209 bits (533), Expect = 1e-54, Method: Composition-based stats. Identities = 67/311 (21%), Positives = 125/311 (40%), Gaps = 50/311 (16%) Query: 2 EKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIRE 61 EKD + + ++G G +G+V+ A K+ VA+K ++ + + + E Sbjct: 6 EKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTK--VAVKTMKPGSMS---VEAFLAE 60 Query: 62 VAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPGVPTE 120 V++ L+ H +V+L V T + + ++ E + L +L P Sbjct: 61 ANVMKTLQ---HDKLVKLHAVVT------KEPIYIITEFMAKGSLLDFLKSDEGSKQPLP 111 Query: 121 TIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSF--QMALTS 178 + D Q+ G+ F+ +HRDL+ NILV++S K+ADFGLAR+ A Sbjct: 112 KLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREG 171 Query: 179 VVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILDVIGL 237 + + APE + S+ D+WS G + E+ + + G S+ + + + + Sbjct: 172 AKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRM 231 Query: 238 PGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSH 297 P E+ P E +++++C P +R + Sbjct: 232 PRPENCP--------------------------EELYNIMMRCWKNRPEERPTFE----- 260 Query: 298 PYFQDLERCKE 308 Y Q + E Sbjct: 261 -YIQSVLDDFE 270 >3VN9-A nrPDB Length = 340 Score = 209 bits (533), Expect = 1e-54, Method: Composition-based stats. Identities = 72/298 (24%), Positives = 127/298 (42%), Gaps = 42/298 (14%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 E + E+G GAYG V K R + G+ +A+KR+R + + ++ + + T Sbjct: 51 DDLEPIMELGRGAYGVVEKMRHV-PSGQIMAVKRIRATVNSQEQK-RLLMDLDI--SMRT 106 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPG--VPTETIKDMMFQ 128 + P V + RE + + E +D L + +V + G +P + + + Sbjct: 107 VDCPFTVTFYGALF-----REGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVS 161 Query: 129 LLRGLDFLHSH-RVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRA 187 +++ L+ LHS V+HRD+KP N+L+ + GQ+K+ DFG++ +A T Y A Sbjct: 162 IVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMA 221 Query: 188 PEVL----LQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILDVIGLPGEED 242 PE + Q Y+ D+WS+G E+ R P + QL ++++ Sbjct: 222 PERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVE--------- 272 Query: 243 WPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 P +KF D +CL N +R + + HP+F Sbjct: 273 ------------EPSPQLPADKF----SAEFVDFTSQCLKKNSKERPTYPELMQHPFF 314 >4IAN-A nrPDB Length = 358 Score = 209 bits (532), Expect = 1e-54, Method: Composition-based stats. Identities = 87/328 (26%), Positives = 141/328 (42%), Gaps = 41/328 (12%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLE 69 D++Y G+G + V +ARD + VA+K +R E M + ++E+ L+ L Sbjct: 29 DKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIR---NNELMQKTGLKELEFLKKLN 85 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKV-PEPGVPTETIKDMMFQ 128 + + + + + L LVFE + +L L K + G+ + ++ Q Sbjct: 86 DADPDD--KFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVGLHIKAVRSYSQQ 143 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQI-KLADFGLARIYSFQMALTSVVVTLWYRA 187 L L L ++H D+KP NILV S I KL DFG A +T +V+ +YRA Sbjct: 144 LFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASHV-ADNDITPYLVSRFYRA 202 Query: 188 PEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPR-- 245 PE+++ SY +D+WSVGC E++ K LF G ++ L +D+ G + + Sbjct: 203 PEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPNKMIRKGV 262 Query: 246 ------------------DVALPRQAFHSKSAQPIEKFVTDIDE-------------LGK 274 V + + P + + D+ K Sbjct: 263 FKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLADLIGCQRLPEDQRKKVHQLK 322 Query: 275 DLLLKCLTFNPAKRISAYSALSHPYFQD 302 DLL + L +PAKRIS AL H + Q+ Sbjct: 323 DLLDQILMLDPAKRISINQALQHAFIQE 350 >6GVJ-A nrPDB Length = 429 Score = 209 bits (531), Expect = 2e-54, Method: Composition-based stats. Identities = 78/303 (25%), Positives = 126/303 (41%), Gaps = 49/303 (16%) Query: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 Y + +IG G KVF+ + K + A+K V ++ + S E+A L L+ Sbjct: 146 YSILKQIGSGGSSKVFQVLNEK--KQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQ-H 202 Query: 73 HPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRG 132 ++RL+D + + +V E + DL ++L K + + K +L Sbjct: 203 SDKIIRLYDYEIT-----DQYIYMVMECGNIDLNSWLKK--KKSIDPWERKSYWKNMLEA 255 Query: 133 LDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMA---LTSVVVTLWYRAPE 189 + +H H +VH DLKP N L+ G +KL DFG+A S V T+ Y PE Sbjct: 256 VHTIHQHGIVHSDLKPANFLIV-DGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPE 314 Query: 190 VLLQSSYATP-----------VDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLP 238 + S + D+WS+GCI M K F+ ++Q+ K+ +I Sbjct: 315 AIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ--QIINQISKLHAIIDPN 372 Query: 239 GEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHP 298 E ++P + +D+L CL +P +RIS L+HP Sbjct: 373 HEIEFPDIPE----------------------KDLQDVLKCCLKRDPKQRISIPELLAHP 410 Query: 299 YFQ 301 Y Q Sbjct: 411 YVQ 413 >5A46-A nrPDB Length = 386 Score = 209 bits (531), Expect = 2e-54, Method: Composition-based stats. Identities = 63/316 (19%), Positives = 125/316 (39%), Gaps = 59/316 (18%) Query: 6 LCRADQQYECVAEIGEGAYGKVFKA------RDLKNGGRFVALKRVRVQTGEEGMPLSTI 59 + +GEG +G+V A +D N VA+K ++ E+ + I Sbjct: 35 WELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLS-DLI 93 Query: 60 REVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLD-------- 110 E+ +++ + +H N++ L CT ++ L ++ E+ +L YL Sbjct: 94 SEMEMMKMIG--KHKNIINLLGACT-----QDGPLYVIVEYASKGNLREYLQARRPPGLE 146 Query: 111 ------KVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADF 164 PE + ++ + +Q+ RG+++L S + +HRDL +N+LVT +K+ADF Sbjct: 147 YCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADF 206 Query: 165 GLAR---IYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFR 220 GLAR + T+ + + + APE L Y D+WS G + E+F + Sbjct: 207 GLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYP 266 Query: 221 GSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKC 280 G + + + + + ++ + ++ C Sbjct: 267 GVPVEELFKLLKEGHRMDKPSNCTNELYM--------------------------MMRDC 300 Query: 281 LTFNPAKRISAYSALS 296 P++R + + Sbjct: 301 WHAVPSQRPTFKQLVE 316 >4PDO-A nrPDB Length = 299 Score = 209 bits (531), Expect = 2e-54, Method: Composition-based stats. Identities = 59/270 (21%), Positives = 114/270 (42%), Gaps = 18/270 (6%) Query: 17 AEIGEGAYGKVFKARDLKNGGRF---VALKRVRVQTGEEGMPLSTIREVAVLRHLETFEH 73 IG G +G+V+K + G+ VA+K ++ E+ + + E ++ F H Sbjct: 40 KVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEK-QRVDFLGEAGIM---GQFSH 95 Query: 74 PNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGL 133 N++RL V + + + ++ E+++ + + + M+ + G+ Sbjct: 96 HNIIRLEGVISKYK-----PMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAGM 150 Query: 134 DFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALT----SVVVTLWYRAPE 189 +L + VHRDL +NILV S+ K++DFGL+R+ T + + + APE Sbjct: 151 KYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPE 210 Query: 190 VLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA 248 + + + D+WS G + E+ + + S+ + + I D LP D P + Sbjct: 211 AISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIY 270 Query: 249 LPRQAFHSKSAQPIEKFVTDIDELGKDLLL 278 + KF + L K L+ Sbjct: 271 QLMMQCWQQERARRPKFADIVSILDK-LIR 299 >5FET-A nrPDB Length = 847 Score = 208 bits (529), Expect = 3e-54, Method: Composition-based stats. Identities = 75/313 (23%), Positives = 120/313 (38%), Gaps = 48/313 (15%) Query: 14 ECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQT---GEEGMPLSTIREVAVLRHLET 70 E IG G +G V K ALK V ++ + + RE+ Sbjct: 536 ETERIIGRGTFGTVKLV-HHKPTQIRYALKCVSKRSIISLNQQNNIKLEREIT-----AE 589 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPGVPTETIKDMMFQL 129 +HP ++RL S + E V +L + K+ + + + + Sbjct: 590 NDHPFIIRLVRTFKDSNC-----FYFLTELVTGGELYDAIRKLG--LLSKPQAQFYLGSI 642 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPE 189 + +++LH +V+RDLKP+NIL+ G +KL DFG A+ Q ++V T Y APE Sbjct: 643 ILAIEYLHERNIVYRDLKPENILLDKQGYVKLIDFGCAKKI--QGRAYTLVGTPHYMAPE 700 Query: 190 VLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVAL 249 V+L Y VD+W++G E F G+ DQL D++ G+ +P V+ Sbjct: 701 VILGKGYGCTVDIWALGVCLYEFICGPLPF-GNDQEDQLEIFRDIL--TGQLTFPDYVS- 756 Query: 250 PRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISA-----YSALSHPYFQDLE 304 D+ +L+ + L P RI H +F + Sbjct: 757 --------------------DQDSINLMKRLLCRLPQGRIGCSINGFKDIKEHAFFGNFN 796 Query: 305 RCKENLDSHLPPS 317 K PP Sbjct: 797 WDKLAGRLLEPPL 809 >3GQL-A nrPDB Length = 326 Score = 207 bits (528), Expect = 4e-54, Method: Composition-based stats. Identities = 64/316 (20%), Positives = 126/316 (39%), Gaps = 59/316 (18%) Query: 6 LCRADQQYECVAEIGEGAYGKVFKA------RDLKNGGRFVALKRVRVQTGEEGMPLSTI 59 + +GEGA+G+V A +D N VA+K ++ E+ + I Sbjct: 23 WELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLS-DLI 81 Query: 60 REVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLD-------- 110 E+ +++ + +H N++ L CT ++ L ++ E+ +L YL Sbjct: 82 SEMEMMKMIG--KHKNIINLLGACT-----QDGPLYVIVEYASKGNLREYLQARRPPGLE 134 Query: 111 ------KVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADF 164 PE + ++ + +Q+ RG+++L S + +HRDL +N+LVT +K+ADF Sbjct: 135 YCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADF 194 Query: 165 GLAR---IYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFR 220 GLAR + T+ + + + APE L Y D+WS G + E+F + Sbjct: 195 GLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYP 254 Query: 221 GSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKC 280 G + + + + + ++ + ++ C Sbjct: 255 GVPVEELFKLLKEGHRMDKPSNCTNELYM--------------------------MMRDC 288 Query: 281 LTFNPAKRISAYSALS 296 P++R + + Sbjct: 289 WHAVPSQRPTFKQLVE 304 >2VD5-A nrPDB Length = 412 Score = 207 bits (528), Expect = 4e-54, Method: Composition-based stats. Identities = 82/320 (25%), Positives = 127/320 (39%), Gaps = 47/320 (14%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLE 69 +E + IG GA+ +V +K G+ A+K + + +S RE L Sbjct: 60 RDDFEILKVIGRGAFSEV-AVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREER--DVLV 116 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEH-VDQDLTTYLDKVPEPGVPTETIKDMMFQ 128 + + +L E L LV E+ V DL T L K E +P E + + + Sbjct: 117 NGDRRWITQLHFAF-----QDENYLYLVMEYYVGGDLLTLLSKFGER-IPAEMARFYLAE 170 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSV--VVTLWYR 186 ++ +D +H VHRD+KP NIL+ G I+LADFG + S+ V T Y Sbjct: 171 IVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYL 230 Query: 187 APEVLL-------QSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPG 239 +PE+L SY D W++G EMF + F S + GKI+ Sbjct: 231 SPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIV------- 283 Query: 240 EEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRI---SAYSALS 296 H K + + E +D + + L P R+ A + Sbjct: 284 ---------------HYKEHLSLPLVDEGVPEEARDFIQRLLCP-PETRLGRGGAGDFRT 327 Query: 297 HPYFQDLERCKENLDSHLPP 316 HP+F L+ + L +PP Sbjct: 328 HPFFFGLDW--DGLRDSVPP 345 >1TKI-A nrPDB Length = 321 Score = 207 bits (528), Expect = 4e-54, Method: Composition-based stats. Identities = 64/316 (20%), Positives = 122/316 (38%), Gaps = 38/316 (12%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 ++Y ++G G +G V + + + ++A K V+V+ ++ + +E+++L Sbjct: 5 EKYMIAEDLGRGEFGIVHRCVETSSKKTYMA-KFVKVKGTDQVLVK---KEISIL---NI 57 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130 H N++ L + +L ++FE + + I + Q+ Sbjct: 58 ARHRNILHLHESFESME-----ELVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVC 112 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTS--SGQIKLADFGLARIYSFQMALTSVVVTLWYRAP 188 L FLHSH + H D++P+NI+ + S IK+ +FG AR + Y AP Sbjct: 113 EALQFLHSHNIGHFDIRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLFTAPEYYAP 172 Query: 189 EVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA 248 EV +T D+WS+G + + F ++ + I++ EE + Sbjct: 173 EVHQHDVVSTATDMWSLGTLVYVLLSGINPFLAETNQQIIENIMNAEYTFDEEAFKE--- 229 Query: 249 LPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQD-LERCK 307 I D + + L R++A AL HP+ + +ER Sbjct: 230 --------------------ISIEAMDFVDRLLVKERKSRMTASEALQHPWLKQKIERVS 269 Query: 308 ENLDSHLPPSQNTSEL 323 + L + L Sbjct: 270 TKVIRTLKHRRYYHTL 285 >4XLV-A nrPDB Length = 328 Score = 207 bits (527), Expect = 6e-54, Method: Composition-based stats. Identities = 73/323 (22%), Positives = 133/323 (41%), Gaps = 58/323 (17%) Query: 4 DGLCRADQQYECVAEIGEGAYGKVFK--ARDLKNGG--RFVALKRVRVQTGEEGMPLSTI 59 D + ++ + E+G+G++G V++ ARD+ G VA+K V ++ + + Sbjct: 32 DEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVN-ESASLRERIEFL 90 Query: 60 REVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVP----- 113 E +V++ F +VVRL V + + +V E + DL +YL + Sbjct: 91 NEASVMK---GFTCHHVVRLLGVVSKGQ-----PTLVVMELMAHGDLKSYLRSLRPEAEN 142 Query: 114 ---EPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLAR-I 169 P + + M ++ G+ +L++ + VHRDL +N +V +K+ DFG+ R I Sbjct: 143 NPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDI 202 Query: 170 YSFQMALTSVVV--TLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVD 226 Y + + APE L + T D+WS G + E+ + ++G S+ Sbjct: 203 YETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQ 262 Query: 227 QLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPA 286 L ++D L ++ P V DL+ C FNP Sbjct: 263 VLKFVMDGGYLDQPDNCPERVT--------------------------DLMRMCWQFNPN 296 Query: 287 KRISAYSALS------HPYFQDL 303 R + ++ HP F ++ Sbjct: 297 MRPTFLEIVNLLKDDLHPSFPEV 319 >1AD5-A nrPDB Length = 438 Score = 207 bits (527), Expect = 6e-54, Method: Composition-based stats. Identities = 66/316 (20%), Positives = 124/316 (39%), Gaps = 52/316 (16%) Query: 2 EKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIRE 61 EKD + + ++G G +G+V+ A K+ VA+K ++ + + + E Sbjct: 173 EKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTK--VAVKTMKPGSMS---VEAFLAE 227 Query: 62 VAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPGVPTE 120 V++ L+ H +V+L V T + + ++ E + L +L P Sbjct: 228 ANVMKTLQ---HDKLVKLHAVVT------KEPIYIITEFMAKGSLLDFLKSDEGSKQPLP 278 Query: 121 TIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVV 180 + D Q+ G+ F+ +HRDL+ NILV++S K+ADFGLAR+ Sbjct: 279 KLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARV--------GAK 330 Query: 181 VTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILDVIGLPG 239 + + APE + S+ D+WS G + E+ + + G S+ + + + +P Sbjct: 331 FPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPR 390 Query: 240 EEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPY 299 E+ P E +++++C P +R + Sbjct: 391 PENCP--------------------------EELYNIMMRCWKNRPEERPTFEYIQ--SV 422 Query: 300 FQDLERCKENLDSHLP 315 D E+ P Sbjct: 423 LDDFYTATESQYQQQP 438 >4AN9-A nrPDB Length = 301 Score = 207 bits (526), Expect = 7e-54, Method: Composition-based stats. Identities = 75/297 (25%), Positives = 129/297 (43%), Gaps = 40/297 (13%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLE 69 D +E ++E+G G G VFK K G +A K + ++ + + IRE+ VL Sbjct: 8 DDDFEKISELGAGNGGVVFKVSH-KPSGLVMARKLIHLEI-KPAIRNQIIRELQVLHECN 65 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQD-LTTYLDKVPEPGVPTETIKDMMFQ 128 + P +V + + ++++ EH+D L L K +P + + + Sbjct: 66 S---PYIVGFYGAFY-----SDGEISICMEHMDGGSLDQVLKKAGR--IPEQILGKVSIA 115 Query: 129 LLRGLDFL-HSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRA 187 +++GL +L H+++HRD+KP NILV S G+IKL DFG++ +MA V T Y + Sbjct: 116 VIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDEMA-NEFVGTRSYMS 174 Query: 188 PEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDV 247 PE L + Y+ D+WS+G EM + + + L I++ Sbjct: 175 PERLQGTHYSVQSDIWSMGLSLVEMAVGRYPRPPMAIFELLDYIVN-------------- 220 Query: 248 ALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLE 304 P + +D + KCL NPA+R + H + + + Sbjct: 221 -----------EPPPKLPSAVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSD 266 >4LFI-A nrPDB Length = 374 Score = 206 bits (525), Expect = 8e-54, Method: Composition-based stats. Identities = 89/343 (25%), Positives = 158/343 (46%), Gaps = 50/343 (14%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVAL-----------------------KRVR 46 + YE ++G G Y +VF+ L + + V K Sbjct: 39 TKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPP 98 Query: 47 VQTGEEGMPLSTIREVAVLRHLETF-------EHPNVVRLFDVCTVSRTDRETKLTLVFE 99 + T ++ VL+ + + H N++ LFD+ + LVFE Sbjct: 99 TTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPA---LVFE 155 Query: 100 HVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTS-SGQ 158 +VD ++ P + I+ MF+LL+ LD+ HS ++HRD+KP N+++ + + Sbjct: 156 YVDN----VDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKK 211 Query: 159 IKLADFGLARIYSFQMALTSVVVTLWYRAPEVLL-QSSYATPVDLWSVGCIFAEM-FRRK 216 ++L D+GLA Y M V + +++ PE+L+ Y +DLWS G + A M F+R+ Sbjct: 212 LRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKRE 271 Query: 217 PLFRGSSDVDQLGKILDVIGLPGEEDW--PRDVALPRQAFHSKS--AQPIEKFVTD---- 268 P F G+S+ DQL KI+ V+G E + ++ LPR+ + +P +F+ D Sbjct: 272 PFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKH 331 Query: 269 --IDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKEN 309 ++ DL+ L ++ +R++A A+ HP+F + E Sbjct: 332 LSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIREQIEK 374 >4XCU-A nrPDB Length = 300 Score = 206 bits (525), Expect = 9e-54, Method: Composition-based stats. Identities = 62/307 (20%), Positives = 117/307 (38%), Gaps = 50/307 (16%) Query: 6 LCRADQQYECVAEIGEGAYGKVFKARD------LKNGGRFVALKRVRVQTGEEGMPLSTI 59 + +GEG +G+V +A + VA+K ++ ++ + + Sbjct: 12 WEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLA-DLV 70 Query: 60 REVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPGVP 118 E+ V++ + H N++ L VCT +E L ++ E +L +L PG Sbjct: 71 SEMEVMKLIG--RHKNIINLLGVCT-----QEGPLYVIVECAAKGNLREFLRARRPPGSS 123 Query: 119 T-----ETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLAR---IY 170 + +Q+ RG+ +L S + +HRDL +N+LVT +K+ADFGLAR Sbjct: 124 EGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHI 183 Query: 171 SFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLG 229 + ++ + + + APE L Y D+WS G + E+F + G + Sbjct: 184 DYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFS 243 Query: 230 KILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRI 289 + + + P L+ +C P++R Sbjct: 244 LLREGHRMDRPPHCP--------------------------PELYGLMRECWHAAPSQRP 277 Query: 290 SAYSALS 296 + + Sbjct: 278 TFKQLVE 284 >3EQC-A nrPDB Length = 360 Score = 206 bits (525), Expect = 9e-54, Method: Composition-based stats. Identities = 79/314 (25%), Positives = 133/314 (42%), Gaps = 32/314 (10%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLE 69 D +E ++E+G G G VFK K G +A K + ++ + + IRE+ VL Sbjct: 32 DDDFEKISELGAGNGGVVFKVSH-KPSGLVMARKLIHLEI-KPAIRNQIIRELQVLHECN 89 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQD-LTTYLDKVPEPGVPTETIKDMMFQ 128 + P +V + + ++++ EH+D L L K +P + + + Sbjct: 90 S---PYIVGFYGAFY-----SDGEISICMEHMDGGSLDQVLKKAGR--IPEQILGKVSIA 139 Query: 129 LLRGLDFL-HSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRA 187 +++GL +L H+++HRD+KP NILV S G+IKL DFG++ MA S V T Y + Sbjct: 140 VIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA-NSFVGTRSYMS 198 Query: 188 PEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKI-LDVIGLPGE------ 240 PE L + Y+ D+WS+G EM + + V G E Sbjct: 199 PERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPR 258 Query: 241 ----------EDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRIS 290 D +A+ + + P + +D + KCL NPA+R Sbjct: 259 TPGRPLNKFGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERAD 318 Query: 291 AYSALSHPYFQDLE 304 + H + + + Sbjct: 319 LKQLMVHAFIKRSD 332 >6E2O-A nrPDB Length = 295 Score = 206 bits (524), Expect = 1e-53, Method: Composition-based stats. Identities = 79/324 (24%), Positives = 132/324 (40%), Gaps = 49/324 (15%) Query: 3 KDGLCRAD---QQYECVA-----EIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGM 54 ++G C +D YE +G+G YG V+ RDL N R +A+K + + Sbjct: 6 EEGDCESDLLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVR-IAIKEIPERDSRYSQ 64 Query: 55 PLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPE 114 PL E+A+ +HL+ H N+V+ + + + E V + L + Sbjct: 65 PLHE--EIALHKHLK---HKNIVQYLGSFS-----ENGFIKIFMEQVPGGSLSALLRSKW 114 Query: 115 PGV--PTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTS-SGQIKLADFGLARIYS 171 + +TI Q+L GL +LH +++VHRD+K N+L+ + SG +K++DFG ++ + Sbjct: 115 GPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLA 174 Query: 172 FQMALT-SVVVTLWYRAPEVLLQ--SSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQL 228 T + TL Y APE++ + Y D+WS+GC EM KP F Sbjct: 175 GINPCTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFY-------- 226 Query: 229 GKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKR 288 F + + + K +LKC +P KR Sbjct: 227 ----------------ELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKR 270 Query: 289 ISAYSALSHPYFQDLERCKENLDS 312 A L + + + K+ Sbjct: 271 ACANDLLVDEFLKVSSKKKKTQPK 294 >3V5Q-A nrPDB Length = 297 Score = 206 bits (524), Expect = 1e-53, Method: Composition-based stats. Identities = 67/303 (22%), Positives = 119/303 (39%), Gaps = 59/303 (19%) Query: 15 CVAEIGEGAYGKVFKARDLK----NGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 E+GEGA+GKVF A VA+K ++ T RE +L +L+ Sbjct: 19 LKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTL--AARKDFQREAELLTNLQ- 75 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLD--------------KVPEP 115 H ++V+ + VC L +VFE++ DL +L + + Sbjct: 76 --HEHIVKFYGVC-----GDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKG 128 Query: 116 GVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY---SF 172 + + + Q+ G+ +L S VHRDL +N LV ++ +K+ DFG++R + Sbjct: 129 ELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDY 188 Query: 173 QMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKI 231 ++ + + PE ++ + T D+WS G I E+F K + S+ + + I Sbjct: 189 YRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECI 248 Query: 232 LDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISA 291 L P++V D++L C P +R++ Sbjct: 249 TQGRVLERPRVCPKEV--------------------------YDVMLGCWQREPQQRLNI 282 Query: 292 YSA 294 Sbjct: 283 KEI 285 >3FME-A nrPDB Length = 290 Score = 206 bits (524), Expect = 1e-53, Method: Composition-based stats. Identities = 71/304 (23%), Positives = 127/304 (41%), Gaps = 42/304 (13%) Query: 5 GLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAV 64 + E + E+G GAYG V K R + G+ +A+KR+R + + ++ + Sbjct: 1 SMEVKADDLEPIMELGRGAYGVVEKMRHV-PSGQIMAVKRIRATVNSQEQK-RLLMDLDI 58 Query: 65 LRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPG--VPTETI 122 + T + P V + RE + + E +D L + +V + G +P + + Sbjct: 59 --SMRTVDCPFTVTFYGALF-----REGDVWICMELMDTSLDKFYKQVIDKGQTIPEDIL 111 Query: 123 KDMMFQLLRGLDFLHSH-RVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVV 181 + +++ L+ LHS V+HRD+KP N+L+ + GQ+K+ DFG++ +A Sbjct: 112 GKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDDVAKDIDAG 171 Query: 182 TLWYRAPEVL----LQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILDVIG 236 Y APE + Q Y+ D+WS+G E+ R P + QL ++++ Sbjct: 172 CKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVE--- 228 Query: 237 LPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALS 296 P +KF D +CL N +R + + Sbjct: 229 ------------------EPSPQLPADKF----SAEFVDFTSQCLKKNSKERPTYPELMQ 266 Query: 297 HPYF 300 HP+F Sbjct: 267 HPFF 270 >1FVR-A nrPDB Length = 327 Score = 206 bits (524), Expect = 1e-53, Method: Composition-based stats. Identities = 72/302 (23%), Positives = 117/302 (38%), Gaps = 51/302 (16%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRF-VALKRVRVQTGEEGMPLSTIREVAVLRHLE 69 + IGEG +G+V KAR K+G R A+KR++ + + E+ VL L Sbjct: 25 NDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMK-EYASKDDHRDFAGELEVLCKLG 83 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVP--------------E 114 HPN++ L C + L L E+ +L +L K Sbjct: 84 --HHPNIINLLGAC-----EHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTA 136 Query: 115 PGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQM 174 + ++ + + RG+D+L + +HRDL +NILV + K+ADFGL+R + Sbjct: 137 STLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYV 196 Query: 175 ALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILD 233 T + + + A E L S Y T D+WS G + E+ + G + + K+ Sbjct: 197 KKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQ 256 Query: 234 VIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYS 293 L + D+ DL+ +C P +R S Sbjct: 257 GYRLEKPLNC--------------------------DDEVYDLMRQCWREKPYERPSFAQ 290 Query: 294 AL 295 L Sbjct: 291 IL 292 >6BXI-A nrPDB Length = 333 Score = 205 bits (523), Expect = 2e-53, Method: Composition-based stats. Identities = 79/339 (23%), Positives = 132/339 (38%), Gaps = 78/339 (23%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR-EVAVLRHLE 69 + +E + IG GA+G+V + K+ G A+K +R E + IR E +L + Sbjct: 6 EDFESLKVIGRGAFGEVRLVQ-KKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEAD 64 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPGVPTETIKDMMFQ 128 + VV++F + L L+ E + D+ T L K + + E + + + Sbjct: 65 SL---WVVKMFYSF-----QDKLNLYLIMEFLPGGDMMTLLMK--KDTLTEEETQFYIAE 114 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY------------------ 170 + +D +H +HRD+KP N+L+ S G +KL+DFGL Sbjct: 115 TVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPS 174 Query: 171 ------------------SFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEM 212 + + S V T Y APEV +Q+ Y D WS+G I EM Sbjct: 175 DFTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEM 234 Query: 213 FRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDEL 272 P F + + K+++ W + P + I E Sbjct: 235 LIGYPPFCSETPQETYKKVMN---------WKETLTFPPEVP--------------ISEK 271 Query: 273 GKDLLLK-CLTFNPAKRISA---YSALSHPYFQDLERCK 307 KDL+L+ C + RI A S+ +F+ ++ Sbjct: 272 AKDLILRFCCEWEH--RIGAPGVEEIKSNSFFEGVDWEH 308 >2PL0-A nrPDB Length = 289 Score = 205 bits (523), Expect = 2e-53, Method: Composition-based stats. Identities = 60/292 (20%), Positives = 117/292 (40%), Gaps = 44/292 (15%) Query: 3 KDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREV 62 +D + + V +G G +G+V+ NG VA+K ++ + P + + E Sbjct: 15 EDEWEVPRETLKLVERLGAGQFGEVWMGYY--NGHTKVAVKSLKQGSMS---PDAFLAEA 69 Query: 63 AVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPGVPTET 121 +++ L+ H +VRL+ V T + ++ E+++ L +L + Sbjct: 70 NLMKQLQ---HQRLVRLYAVVTQE------PIYIITEYMENGSLVDFLKTPSGIKLTINK 120 Query: 122 IKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSF--QMALTSV 179 + DM Q+ G+ F+ +HRDL+ NILV+ + K+ADFGLAR+ A Sbjct: 121 LLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGA 180 Query: 180 VVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILDVIGLP 238 + + APE + ++ D+WS G + E+ + + G ++ + + + + Sbjct: 181 KFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMV 240 Query: 239 GEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRIS 290 ++ P E L+ C P R + Sbjct: 241 RPDNCP--------------------------EELYQLMRLCWKERPEDRPT 266 >4OTD-A nrPDB Length = 341 Score = 205 bits (523), Expect = 2e-53, Method: Composition-based stats. Identities = 68/314 (21%), Positives = 122/314 (38%), Gaps = 44/314 (14%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRV-QTGEEGMPLSTIREVAVLRHLE 69 + ++ +A +G G +GKV + + + G A+K ++ S + E +L + Sbjct: 12 EDFKFLAVLGRGHFGKVLLS-EFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVT 70 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEH-VDQDLTTYLDKVPEPGVPTETIKDMMFQ 128 + HP +V LF + V E+ DL ++ Sbjct: 71 SAGHPFLVNLFGCFQTPE-----HVCFVMEYSAGGDLMLHIHS---DVFSEPRAIFYSAC 122 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARI-YSFQMALTSVVVTLWYRA 187 ++ GL FLH H++V+RDLK N+L+ + G +K+ADFGL + + ++ T + A Sbjct: 123 VVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLA 182 Query: 188 PEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDV 247 PEVL +SY VD W +G + EM + F G + + I++ Sbjct: 183 PEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVN-------------- 228 Query: 248 ALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRI-----SAYSALSHPYFQD 302 ++ + ++ + L NP +R+ A P+F+ Sbjct: 229 -------------DEVRYPRFLSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFFRT 275 Query: 303 LERCKENLDSHLPP 316 L PP Sbjct: 276 LGWEALLARRLPPP 289 >4CRS-A nrPDB Length = 341 Score = 205 bits (522), Expect = 2e-53, Method: Composition-based stats. Identities = 67/313 (21%), Positives = 121/313 (38%), Gaps = 42/313 (13%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRV-QTGEEGMPLSTIREVAVLRHLE 69 Q + C A + G +GKV A + KN A+K ++ S + E + + Sbjct: 12 QDFRCCAVLLRGHFGKVLLA-EYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVN 70 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQL 129 + HP +V LF + + V E+ + + + Sbjct: 71 SVRHPFLVNLFACFQT-----KEHVCFVMEYAAGG--DLMMHIHTDVFSEPRAVFYAACV 123 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARI-YSFQMALTSVVVTLWYRAP 188 + GL +LH H++V+RDLK N+L+ + G +K+ADFGL + + ++ T + AP Sbjct: 124 VLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAP 183 Query: 189 EVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA 248 EVL ++SY VD W +G + EM + F G + + I++ Sbjct: 184 EVLTETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVN--------------- 228 Query: 249 LPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYS-----ALSHPYFQDL 303 ++ + ++ + L NP +R+ A HP+F+ + Sbjct: 229 ------------DEVRYPRFLSTEAISIMRRLLRRNPERRLGASEKDAEDVKKHPFFRLI 276 Query: 304 ERCKENLDSHLPP 316 + PP Sbjct: 277 DWSALMDKKVKPP 289 >2PSQ-A nrPDB Length = 370 Score = 205 bits (522), Expect = 2e-53, Method: Composition-based stats. Identities = 63/316 (19%), Positives = 127/316 (40%), Gaps = 59/316 (18%) Query: 6 LCRADQQYECVAEIGEGAYGKVFKA------RDLKNGGRFVALKRVRVQTGEEGMPLSTI 59 + +GEG +G+V A +D VA+K ++ E+ + + Sbjct: 76 WEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLS-DLV 134 Query: 60 REVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLD-------- 110 E+ +++ + +H N++ L CT ++ L ++ E+ +L YL Sbjct: 135 SEMEMMKMIG--KHKNIINLLGACT-----QDGPLYVIVEYASKGNLREYLRARRPPGME 187 Query: 111 ------KVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADF 164 +VPE + + + +QL RG+++L S + +HRDL +N+LVT + +K+ADF Sbjct: 188 YSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADF 247 Query: 165 GLARIYS---FQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFR 220 GLAR + + T+ + + + APE L Y D+WS G + E+F + Sbjct: 248 GLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYP 307 Query: 221 GSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKC 280 G + + + + + ++ + ++ C Sbjct: 308 GIPVEELFKLLKEGHRMDKPANCTNELYM--------------------------MMRDC 341 Query: 281 LTFNPAKRISAYSALS 296 P++R + + Sbjct: 342 WHAVPSQRPTFKQLVE 357 >4YHJ-A nrPDB Length = 584 Score = 205 bits (522), Expect = 2e-53, Method: Composition-based stats. Identities = 71/310 (22%), Positives = 122/310 (39%), Gaps = 37/310 (11%) Query: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 + +G+G +G+V + G + K + + + + E +L +++ Sbjct: 187 FRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQS-- 244 Query: 73 HPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQLLR 131 VV L + + L LV ++ DL ++ + PG + +L Sbjct: 245 -RFVVSL-----AYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCC 298 Query: 132 GLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVL 191 GL+ L R+V+RDLKP+NIL+ G I+++D GLA + V T+ Y APEV+ Sbjct: 299 GLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVV 358 Query: 192 LQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPR 251 Y D W +GC+ EM + F+ + + ++ I EE Sbjct: 359 NNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEE---------- 408 Query: 252 QAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRI-----SAYSALSHPYFQDLERC 306 + E K + LT NP+KR+ A HP F+D+ Sbjct: 409 -------------YSEKFSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFR 455 Query: 307 KENLDSHLPP 316 + + PP Sbjct: 456 RLEANMLEPP 465 >1S9I-A nrPDB Length = 354 Score = 204 bits (520), Expect = 3e-53, Method: Composition-based stats. Identities = 81/318 (25%), Positives = 138/318 (43%), Gaps = 36/318 (11%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLE 69 D +E ++E+G G G V K + + G +A K + ++ + + IRE+ VL Sbjct: 15 DDDFERISELGAGNGGVVTKVQH-RPSGLIMARKLIHLEI-KPAIRNQIIRELQVLHECN 72 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQL 129 + P +V + + ++++ EH+D + K + +P E + + + Sbjct: 73 S---PYIVGFYGAFY-----SDGEISICMEHMDGGSLDQVLKEAKR-IPEEILGKVSIAV 123 Query: 130 LRGLDFL-HSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAP 188 LRGL +L H+++HRD+KP NILV S G+IKL DFG++ MA S V T Y AP Sbjct: 124 LRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA-NSFVGTRSYMAP 182 Query: 189 EVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA 248 E L + Y+ D+WS+G E+ + + L I + GEE P ++ Sbjct: 183 ERLQGTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKE-LEAIFGRPVVDGEEGEPHSIS 241 Query: 249 LPRQAF------HSKSAQPIEKFVTDID----------------ELGKDLLLKCLTFNPA 286 + H ++P +D ++ + KCL NPA Sbjct: 242 PRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPA 301 Query: 287 KRISAYSALSHPYFQDLE 304 +R +H + + E Sbjct: 302 ERADLKMLTNHTFIKRSE 319 >3KUL-B nrPDB Length = 325 Score = 204 bits (520), Expect = 4e-53, Method: Composition-based stats. Identities = 60/291 (20%), Positives = 112/291 (38%), Gaps = 42/291 (14%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFV--ALKRVRVQTGEEGMPLSTIREVAVLRHL 68 + IG G G+V R G R V A+K ++ E + E +++ Sbjct: 49 SRIHIEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGYT-ERQRRDFLSEASIM--- 104 Query: 69 ETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQ 128 F+HPN++RL V T R +V E+++ + + + M+ Sbjct: 105 GQFDHPNIIRLEGVVTRGRLA-----MIVTEYMENGSLDTFLRTHDGQFTIMQLVGMLRG 159 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQ----MALTSVVVTLW 184 + G+ +L VHRDL +N+LV S+ K++DFGL+R+ T + + Sbjct: 160 VGAGMRYLSDLGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIR 219 Query: 185 YRAPEVLLQSSYATPVDLWSVGCIFAE-MFRRKPLFRGSSDVDQLGKILDVIGLPGEEDW 243 + APE + ++++ D+WS G + E + + + ++ D + + + LP Sbjct: 220 WTAPEAIAFRTFSSASDVWSFGVVMWEVLAYGERPYWNMTNRDVISSVEEGYRLPAPMGC 279 Query: 244 PRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSA 294 P + L+L C + A+R Sbjct: 280 PHAL--------------------------HQLMLDCWHKDRAQRPRFSQI 304 >3HMP-A nrPDB Length = 342 Score = 204 bits (520), Expect = 4e-53, Method: Composition-based stats. Identities = 78/303 (25%), Positives = 126/303 (41%), Gaps = 49/303 (16%) Query: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 Y + +IG G KVF+ + K + A+K V ++ + S E+A L L+ Sbjct: 58 YSILKQIGSGGSSKVFQVLNEK--KQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQ-H 114 Query: 73 HPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRG 132 ++RL+D + + +V E + DL ++L K + + K +L Sbjct: 115 SDKIIRLYDYEIT-----DQYIYMVMECGNIDLNSWLKK--KKSIDPWERKSYWKNMLEA 167 Query: 133 LDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMA---LTSVVVTLWYRAPE 189 + +H H +VH DLKP N L+ G +KL DFG+A S V T+ Y PE Sbjct: 168 VHTIHQHGIVHSDLKPANFLIV-DGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPE 226 Query: 190 VLLQSSYATP-----------VDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLP 238 + S + D+WS+GCI M K F+ ++Q+ K+ +I Sbjct: 227 AIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ--QIINQISKLHAIIDPN 284 Query: 239 GEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHP 298 E ++P + +D+L CL +P +RIS L+HP Sbjct: 285 HEIEFPDIPE----------------------KDLQDVLKCCLKRDPKQRISIPELLAHP 322 Query: 299 YFQ 301 Y Q Sbjct: 323 YVQ 325 >2OGV-A nrPDB Length = 317 Score = 204 bits (520), Expect = 4e-53, Method: Composition-based stats. Identities = 64/316 (20%), Positives = 117/316 (37%), Gaps = 52/316 (16%) Query: 4 DGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGR----FVALKRVRVQTGEEGMPLSTI 59 + + +G GA+GKV +A G VA+K ++ T + + Sbjct: 31 EKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLK-STAHADEKEALM 89 Query: 60 REVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPGVP 118 E+ ++ HL +H N+V L CT + ++ E+ DL +L + E + Sbjct: 90 SELKIMSHLG--QHENIVNLLGACT-----HGGPVLVITEYCCYGDLLNFLRRKAEADLD 142 Query: 119 TET--------IKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY 170 E + Q+ +G+ FL S +HRD+ +N+L+T+ K+ DFGLAR Sbjct: 143 KEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDI 202 Query: 171 SFQMAL---TSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVD 226 + + + + APE + Y D+WS G + E+F + G Sbjct: 203 MNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNS 262 Query: 227 QLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPA 286 + K++ + + AF K+ ++ C P Sbjct: 263 KFYKLVK-----------DGYQMAQPAFAPKNIYS--------------IMQACWALEPT 297 Query: 287 KRISAYSALSHPYFQD 302 R + + Q+ Sbjct: 298 HRPTFQQI--CSFLQE 311 >4K33-A nrPDB Length = 325 Score = 204 bits (519), Expect = 5e-53, Method: Composition-based stats. Identities = 61/316 (19%), Positives = 125/316 (39%), Gaps = 59/316 (18%) Query: 6 LCRADQQYECVAEIGEGAYGKVFKA------RDLKNGGRFVALKRVRVQTGEEGMPLSTI 59 + + +GEGA+G+V A +D VA+K ++ ++ + + Sbjct: 31 WELSRARLTLGKPLGEGAFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLS-DLV 89 Query: 60 REVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPGVP 118 E+ +++ + +H N++ L CT + L ++ E+ +L +L PG+ Sbjct: 90 SEMEMMKMIG--KHKNIINLLGACT-----QGGPLYVLVEYAAKGNLREFLRARRPPGLD 142 Query: 119 T--------------ETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADF 164 + + +Q+ RG+++L S + +HRDL +N+LVT +K+ADF Sbjct: 143 YSFDTSKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADF 202 Query: 165 GLARIYS---FQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFR 220 GLAR + T+ + + + APE L Y D+WS G + E+F + Sbjct: 203 GLARDVHNLDYYKETTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYP 262 Query: 221 GSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKC 280 G + + + + + D+ + ++ +C Sbjct: 263 GIPVEELFKLLKEGHRMDKPANCTHDLYM--------------------------IMREC 296 Query: 281 LTFNPAKRISAYSALS 296 P++R + + Sbjct: 297 WHAAPSQRPTFKQLVE 312 >5UUU-A nrPDB Length = 547 Score = 203 bits (518), Expect = 5e-53, Method: Composition-based stats. Identities = 74/325 (22%), Positives = 134/325 (41%), Gaps = 42/325 (12%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGE-EGMPLSTIREVAVLRHLE 69 + IG G +G+V+ R + G+ A+K + + + + + E +L + Sbjct: 198 NDFSVHRIIGRGGFGEVYGCR-KADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 256 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQ 128 T + P +V C KL+ + + ++ DL +L + ++ + Sbjct: 257 TGDCPFIV-----CMSYAFHTPDKLSFILDLMNGGDLHYHLSQ--HGVFSEADMRFYAAE 309 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAP 188 ++ GL+ +H+ VV+RDLKP NIL+ G ++++D GLA +S + S V T Y AP Sbjct: 310 IILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHAS-VGTHGYMAP 368 Query: 189 EVLLQS-SYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDV 247 EVL + +Y + D +S+GC+ ++ R FR D+ +D + L + P Sbjct: 369 EVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHE--IDRMTLTMAVELPDSF 426 Query: 248 ALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRI-----SAYSALSHPYFQD 302 + LL L + +R+ A P+F+ Sbjct: 427 ----------------------SPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRS 464 Query: 303 LERCKENLDSHLPPSQNTS-ELNTA 326 L+ L + PP E+N A Sbjct: 465 LDWQMVFLQKYPPPLIPPRGEVNAA 489 >2BRG-A nrPDB Length = 297 Score = 203 bits (518), Expect = 6e-53, Method: Composition-based stats. Identities = 75/297 (25%), Positives = 126/297 (42%), Gaps = 41/297 (13%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 + ++ V +GEGAYG+V A + + VA+K V ++ + P + +E+ + + L Sbjct: 7 EDWDLVQTLGEGAYGEVQLAVN-RVTEEAVAVKIVDMKRAVD-CPENIKKEICINKML-- 62 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKV-PEPGVPTETIKDMMFQL 129 H NVV+ + L E+ D++ P+ G+P + QL Sbjct: 63 -NHENVVKFYG-----HRREGNIQYLFLEYCSGG--ELFDRIEPDIGMPEPDAQRFFHQL 114 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMA---LTSVVVTLWYR 186 + G+ +LH + HRD+KP+N+L+ +K++DFGLA ++ + L + TL Y Sbjct: 115 MAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYV 174 Query: 187 APEVLLQSSY-ATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPR 245 APE+L + + A PVD+WS G + M + + SD Q Sbjct: 175 APELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQ------------------ 216 Query: 246 DVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQD 302 P +K ID LL K L NP+ RI+ ++ Sbjct: 217 --EYSDWKEKKTYLNPWKK----IDSAPLALLHKILVENPSARITIPDIKKDRWYNK 267 >3BEA-A nrPDB Length = 333 Score = 203 bits (518), Expect = 6e-53, Method: Composition-based stats. Identities = 63/320 (19%), Positives = 117/320 (36%), Gaps = 56/320 (17%) Query: 4 DGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGR----FVALKRVRVQTGEEGMPLSTI 59 + + +G GA+GKV +A G VA+K ++ T + + Sbjct: 39 EKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLK-STAHADEKEALM 97 Query: 60 REVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDK------- 111 E+ ++ HL +H N+V L CT + ++ E+ DL +L + Sbjct: 98 SELKIMSHLG--QHENIVNLLGACT-----HGGPVLVITEYCCYGDLLNFLRRKSRVLET 150 Query: 112 -----VPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGL 166 + + T + Q+ +G+ FL S +HRD+ +N+L+T+ K+ DFGL Sbjct: 151 DPAFAIANSTLSTRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGL 210 Query: 167 ARIYSFQMAL---TSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGS 222 AR + + + + APE + Y D+WS G + E+F + G Sbjct: 211 ARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGI 270 Query: 223 SDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLT 282 + K++ + + AF K+ ++ C Sbjct: 271 LVNSKFYKLVK-----------DGYQMAQPAFAPKNIYS--------------IMQACWA 305 Query: 283 FNPAKRISAYSALSHPYFQD 302 P R + + Q+ Sbjct: 306 LEPTHRPTFQQI--CSFLQE 323 >3C51-A nrPDB Length = 543 Score = 203 bits (517), Expect = 7e-53, Method: Composition-based stats. Identities = 66/309 (21%), Positives = 115/309 (37%), Gaps = 40/309 (12%) Query: 17 AEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNV 76 +G G +G+VF + G + K + + + + E +L + + + Sbjct: 191 RVLGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILAKVHS---RFI 247 Query: 77 VRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPE--PGVPTETIKDMMFQLLRGL 133 V L +T L LV ++ D+ ++ V E PG Q++ GL Sbjct: 248 VSLAYAFET-----KTDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQIVSGL 302 Query: 134 DFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALT-SVVVTLWYRAPEVLL 192 + LH +++RDLKP+N+L+ G ++++D GLA T T + APE+LL Sbjct: 303 EHLHQRNIIYRDLKPENVLLDDDGNVRISDLGLAVELKAGQTKTKGYAGTPGFMAPELLL 362 Query: 193 QSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQ 252 Y VD +++G EM + FR R + + Sbjct: 363 GEEYDFSVDYFALGVTLYEMIAARGPFRA-----------------------RGEKVENK 399 Query: 253 AFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRI-----SAYSALSHPYFQDLERCK 307 + + + KD L +P KR+ S +HP F+D+ + Sbjct: 400 ELKQRVLEQAVTYPDKFSPASKDFCEALLQKDPEKRLGFRDGSCDGLRTHPLFRDISWRQ 459 Query: 308 ENLDSHLPP 316 PP Sbjct: 460 LEAGMLTPP 468 >3KRL-A nrPDB Length = 335 Score = 203 bits (517), Expect = 8e-53, Method: Composition-based stats. Identities = 64/322 (19%), Positives = 118/322 (36%), Gaps = 58/322 (18%) Query: 4 DGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGR----FVALKRVRVQTGEEGMPLSTI 59 + + +G GA+GKV +A G VA+K ++ T + + Sbjct: 39 EKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLK-STAHADEKEALM 97 Query: 60 REVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPGV- 117 E+ ++ HL +H N+V L CT + ++ E+ DL +L + PG+ Sbjct: 98 SELKIMSHLG--QHENIVNLLGACT-----HGGPVLVITEYCCYGDLLNFLRRKRPPGLE 150 Query: 118 -------------PTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADF 164 + + Q+ +G+ FL S +HRD+ +N+L+T+ K+ DF Sbjct: 151 YSYNPSHNPEEQLSSRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDF 210 Query: 165 GLARIYSFQMAL---TSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFR 220 GLAR + + + + APE + Y D+WS G + E+F + Sbjct: 211 GLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYP 270 Query: 221 GSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKC 280 G + K++ + + AF K+ ++ C Sbjct: 271 GILVNSKFYKLVK-----------DGYQMAQPAFAPKNIYS--------------IMQAC 305 Query: 281 LTFNPAKRISAYSALSHPYFQD 302 P R + + Q+ Sbjct: 306 WALEPTHRPTFQQI--CSFLQE 325 >3PVW-A nrPDB Length = 695 Score = 203 bits (516), Expect = 1e-52, Method: Composition-based stats. Identities = 74/325 (22%), Positives = 134/325 (41%), Gaps = 42/325 (12%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGE-EGMPLSTIREVAVLRHLE 69 + IG G +G+V+ R + G+ A+K + + + + + E +L + Sbjct: 189 NDFSVHRIIGRGGFGEVYGCR-KADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 247 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQ 128 T + P +V C KL+ + + ++ DL +L + ++ + Sbjct: 248 TGDCPFIV-----CMSYAFHTPDKLSFILDLMNGGDLHYHLSQ--HGVFSEADMRFYAAE 300 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAP 188 ++ GL+ +H+ VV+RDLKP NIL+ G ++++D GLA +S + S V T Y AP Sbjct: 301 IILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHAS-VGTHGYMAP 359 Query: 189 EVLLQS-SYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDV 247 EVL + +Y + D +S+GC+ ++ R FR D+ +D + L + P Sbjct: 360 EVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHE--IDRMTLTMAVELPDSF 417 Query: 248 ALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRI-----SAYSALSHPYFQD 302 + LL L + +R+ A P+F+ Sbjct: 418 ----------------------SPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRS 455 Query: 303 LERCKENLDSHLPPSQNTS-ELNTA 326 L+ L + PP E+N A Sbjct: 456 LDWQMVFLQKYPPPLIPPRGEVNAA 480 >2X7G-A nrPDB Length = 389 Score = 202 bits (515), Expect = 1e-52, Method: Composition-based stats. Identities = 86/368 (23%), Positives = 148/368 (40%), Gaps = 81/368 (22%) Query: 9 ADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHL 68 + +Y + ++G G + V+ D++ G RFVA+K V+ + + + E+ +L+ + Sbjct: 29 FNGRYHVIRKLGWGHFSTVWLCWDMQ-GKRFVAMKVVKSA---QHYTETALDEIKLLKCV 84 Query: 69 ETFEH--PN---VVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIK 123 + PN VV+L D +S + +VFE + L ++ K G+P +K Sbjct: 85 RESDPSDPNKDMVVQLIDDFKISGM-NGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVK 143 Query: 124 DMMFQLLRGLDFLHSH-RVVHRDLKPQNILV----------------------------- 153 ++ Q+L+GLD+LHS +++H D+KP+NIL+ Sbjct: 144 SIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSA 203 Query: 154 ------------------TSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSS 195 ++K+AD G A T + T YR+ EVL+ + Sbjct: 204 VSTAPAADLLVNPLDPRNADKIRVKIADLGNACWVH--KHFTEDIQTRQYRSIEVLIGAG 261 Query: 196 YATPVDLWSVGCIFAEMFRRKPLFRGSS------DVDQLGKILDVIG-LPGEEDWPRDVA 248 Y+TP D+WS C+ E+ LF S D D + I++++G +P + Sbjct: 262 YSTPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYS 321 Query: 249 LPR-----QAFHSKSAQPIEKF---------VTDIDELGKDLLLKCLTFNPAKRISAYSA 294 + H +P F + D L+ L P KR SA Sbjct: 322 REFFNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGEC 381 Query: 295 LSHPYFQD 302 L HP+ Sbjct: 382 LRHPWLNS 389 >2JD5-A nrPDB Length = 373 Score = 202 bits (515), Expect = 2e-52, Method: Composition-based stats. Identities = 88/336 (26%), Positives = 154/336 (45%), Gaps = 45/336 (13%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLE 69 D +Y V ++G G + V+ A+D+ N VA+K VR G++ + E+ +L+ + Sbjct: 18 DARYILVRKLGWGHFSTVWLAKDMVNN-THVAMKIVR---GDKVYTEAAEDEIKLLQRVN 73 Query: 70 TFEH--------PNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTET 121 ++ ++++L D + + +VFE + ++L + K G+P Sbjct: 74 DADNTKEDSMGANHILKLLDHF-NHKGPNGVHVVMVFEVLGENLLALIKKYEHRGIPLIY 132 Query: 122 IKDMMFQLLRGLDFLHSH-RVVHRDLKPQNILVT------SSGQIKLADFGLARIYSFQM 174 +K + QLL GLD++H ++H D+KP+N+L+ + QIK+AD G A Y Sbjct: 133 VKQISKQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNACWYDEH- 191 Query: 175 ALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGS------SDVDQL 228 T+ + T YR+PEVLL + + D+WS C+ E+ LF D D + Sbjct: 192 -YTNSIQTREYRSPEVLLGAPWGCGADIWSTACLIFELITGDFLFEPDEGHSYTKDDDHI 250 Query: 229 GKILDVIGLPGEEDWPRDVALPRQAFHSK---------SAQPIE-------KFVTDIDEL 272 +I++++G R+ R F+S+ P+E KF D + Sbjct: 251 AQIIELLGELPSYLL-RNGKYTRTFFNSRGLLRNISKLKFWPLEDVLTEKYKFSKDEAKE 309 Query: 273 GKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKE 308 D L L +P KR A ++HP+ +D +E Sbjct: 310 ISDFLSPMLQLDPRKRADAGGLVNHPWLKDTLGMEE 345 >5HI2-A nrPDB Length = 283 Score = 202 bits (514), Expect = 2e-52, Method: Composition-based stats. Identities = 65/300 (21%), Positives = 124/300 (41%), Gaps = 45/300 (15%) Query: 3 KDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREV 62 D D Q IG G++G V+K + + VA+K + Q + + EV Sbjct: 12 SDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD----VAVKMLTPQQLQ-----AFKNEV 62 Query: 63 AVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETI 122 VLR H N++ T + +L +V + + + E + + Sbjct: 63 GVLRK---TRHVNILLFMGYST------KPQLAIVTQWCEGSSLYHHLHASETKFEMKKL 113 Query: 123 KDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARI---YSFQMALTSV 179 D+ Q RG+D+LH+ ++HRDLK NI + +K+ DFGLA + +S + Sbjct: 114 IDIARQTARGMDYLHAKSIIHRDLKSNNIFLHEDNTVKIGDFGLATVKSRWSGSHQFEQL 173 Query: 180 VVTLWYRAPEVLL---QSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIG 236 ++ + APEV+ + Y+ D+++ G + E+ + + ++ DQ I++++G Sbjct: 174 SGSILWMAPEVIRMQDSNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQ---IIEMVG 230 Query: 237 LPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALS 296 + + K ++ + K L+ +CL +R S L+ Sbjct: 231 ------------------RGSLSPDLSKVRSNCPKRMKRLMAECLKKKRDERPSFPRILA 272 >4PWN-A nrPDB Length = 274 Score = 202 bits (514), Expect = 2e-52, Method: Composition-based stats. Identities = 70/289 (24%), Positives = 124/289 (42%), Gaps = 36/289 (12%) Query: 18 EIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVV 77 EIG G++ V+K D + VA ++ + + E +L+ L+ HPN+V Sbjct: 17 EIGRGSFKTVYKGLDTETTVE-VAWCELQDRKLTKSERQRFKEEAEMLKGLQ---HPNIV 72 Query: 78 RLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFL 136 R +D + ++ + LV E + L TYL + + + ++ Q+L+GL FL Sbjct: 73 RFYDSWESTVKGKKC-IVLVTELMTSGTLKTYLKRFK--VMKIKVLRSWCRQILKGLQFL 129 Query: 137 HSHR--VVHRDLKPQNILVTS-SGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQ 193 H+ ++HRDLK NI +T +G +K+ D GLA + SV+ T + APE+ + Sbjct: 130 HTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLEKRASFAKSVIGTPEFMAPEMY-E 188 Query: 194 SSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQA 253 Y VD+++ G EM + + + Q+ + + P D Sbjct: 189 EKYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPASFD----------- 237 Query: 254 FHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQD 302 K+++ C+ N +R S L+H +FQ+ Sbjct: 238 -------------KVAIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQE 273 >5AP3-A nrPDB Length = 313 Score = 202 bits (513), Expect = 2e-52, Method: Composition-based stats. Identities = 78/303 (25%), Positives = 125/303 (41%), Gaps = 49/303 (16%) Query: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 Y + +IG G KVF+ + K + A+K V ++ + S E+A L L+ Sbjct: 30 YSILKQIGSGGSSKVFQVLNEK--KQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQ-H 86 Query: 73 HPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRG 132 ++RL+D + + +V E + DL +L K + + K +L Sbjct: 87 SDKIIRLYDYEIT-----DQYIYMVMECGNIDLNGWLKK--KKSIDPWERKSYWKNMLEA 139 Query: 133 LDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMA---LTSVVVTLWYRAPE 189 + +H H +VH DLKP N L+ G +KL DFG+A S V T+ Y PE Sbjct: 140 VHTIHQHGIVHSDLKPANFLIV-DGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPE 198 Query: 190 VLLQSSYATP-----------VDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLP 238 + S + D+WS+GCI M K F+ ++Q+ K+ +I Sbjct: 199 AIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ--QIINQISKLHAIIDPN 256 Query: 239 GEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHP 298 E ++P + +D+L CL +P +RIS L+HP Sbjct: 257 HEIEFPDIPE----------------------KDLQDVLKCCLKRDPKQRISIPELLAHP 294 Query: 299 YFQ 301 Y Q Sbjct: 295 YVQ 297 >2ZMD-A nrPDB Length = 390 Score = 201 bits (512), Expect = 3e-52, Method: Composition-based stats. Identities = 77/303 (25%), Positives = 125/303 (41%), Gaps = 49/303 (16%) Query: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 Y + +IG G KVF+ + K + A+K V ++ + S E+A L L+ Sbjct: 58 YSILKQIGSGGSSKVFQVLNEK--KQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQ-H 114 Query: 73 HPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRG 132 ++RL+D + + +V E + DL ++L K + + K +L Sbjct: 115 SDKIIRLYDYEIT-----DQYIYMVMECGNIDLNSWLKK--KKSIDPWERKSYWKNMLEA 167 Query: 133 LDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMA---LTSVVVTLWYRAPE 189 + +H H +VH DLKP N L+ G +KL DFG+A S V + Y PE Sbjct: 168 VHTIHQHGIVHSDLKPANFLIV-DGMLKLIDFGIANQMQPDTTSVVKDSQVGAVNYMPPE 226 Query: 190 VLLQSSYATP-----------VDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLP 238 + S + D+WS+GCI M K F+ ++Q+ K+ +I Sbjct: 227 AIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ--QIINQISKLHAIIDPN 284 Query: 239 GEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHP 298 E ++P + +D+L CL +P +RIS L+HP Sbjct: 285 HEIEFPDIPE----------------------KDLQDVLKCCLKRDPKQRISIPELLAHP 322 Query: 299 YFQ 301 Y Q Sbjct: 323 YVQ 325 >4LQP-A nrPDB Length = 508 Score = 201 bits (512), Expect = 3e-52, Method: Composition-based stats. Identities = 74/364 (20%), Positives = 128/364 (35%), Gaps = 103/364 (28%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRV-RVQTGEEGMPLSTIREVAVLRHLE 69 + + V IG+GA+G+V + K+ G+ A+K + + + ++ E VL Sbjct: 102 EDFHTVKVIGKGAFGEVRLVQ-KKDTGKIYAMKTLLKSEMYKKDQLAHVKAERDVL---A 157 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPGVPTETIKDMMFQ 128 + P VV L+ ++ L L+ E + DL T L + + + M + Sbjct: 158 GSDSPWVVSLYYSFQDAQY-----LYLIMEFLPGGDLMTML--IRWQLFTEDVTRFYMAE 210 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADF------------------------ 164 + ++ +H +HR +KP NIL+ G IKL+DF Sbjct: 211 CILAIETIHKLGFIHRAIKPDNILIDIRGHIKLSDFGLSTGFHKTHDSNYYKKLLQQDEA 270 Query: 165 --GLARIYSFQMALT------------------------------------SVVVTLWYR 186 G+++ ++ T S V T Y Sbjct: 271 TNGISKPGTYNANTTDTANKRQTMVVDSISLTMSNRQQIQTWRKSRRLMAYSTVGTPDYI 330 Query: 187 APEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRD 246 APE+ L Y D WS+G I E P F + + KI++ +P D Sbjct: 331 APEIFLYQGYGQECDWWSLGAIMYECLIGWPPFCSETPQETYRKIMNFEQT---LQFPDD 387 Query: 247 VALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRI----SAYSALSHPYFQD 302 + I +DL+ + LT +R+ A SHP+F+ Sbjct: 388 I--------------------HISYEAEDLIRRLLTH-ADQRLGRHGGADEIKSHPFFRG 426 Query: 303 LERC 306 ++ Sbjct: 427 VDWN 430 >3CJF-A nrPDB Length = 309 Score = 201 bits (511), Expect = 4e-52, Method: Composition-based stats. Identities = 69/311 (22%), Positives = 117/311 (37%), Gaps = 51/311 (16%) Query: 6 LCRADQQYECVAEIGEGAYGKVFKA----RDLKNGGRFVALKRVRVQTGEEGMPLSTIRE 61 + +G GA+G+V +A D R VA+K ++ + + E Sbjct: 22 WEFPRDRLNLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHR-ALMSE 80 Query: 62 VAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPGVP-- 118 + +L H+ H NVV L CT L ++ E +L+TYL VP Sbjct: 81 LKILIHIG--HHLNVVNLLGACTKPG----GPLMVIVEFCKFGNLSTYLRSKRNEFVPYK 134 Query: 119 --------TETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY 170 E + FQ+ +G++FL S + +HRDL +NIL++ +K+ DFGLAR Sbjct: 135 DLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDI 194 Query: 171 ---SFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVD 226 + + L + APE + Y D+WS G + E+F + G + Sbjct: 195 YKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDE 254 Query: 227 QLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPA 286 + + L D+ ++ + D C P+ Sbjct: 255 EFCRRLKEGTRMRAPDY---------------------TTPEMYQTMLD----CWHGEPS 289 Query: 287 KRISAYSALSH 297 +R + + H Sbjct: 290 QRPTFSELVEH 300 >5O2B-A nrPDB Length = 285 Score = 200 bits (509), Expect = 6e-52, Method: Composition-based stats. Identities = 71/289 (24%), Positives = 126/289 (43%), Gaps = 37/289 (12%) Query: 18 EIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVV 77 E+G GA+ V+K D + VA ++ + + E +L+ L+ HPN+V Sbjct: 23 ELGRGAFKTVYKGLDTETWVE-VAWCELQDRKLTKAEQQRFKEEAEMLKGLQ---HPNIV 78 Query: 78 RLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFL 136 R +D ++ + LV E + L TYL + + + ++ Q+L+GL FL Sbjct: 79 RFYDSWESILKGKKC-IVLVTELMTSGTLKTYLKRFK--VMKPKVLRSWCRQILKGLQFL 135 Query: 137 HSHR--VVHRDLKPQNILVTS-SGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQ 193 H+ ++HRDLK NI +T +G +K+ D GLA + A SV+ T + APE+ + Sbjct: 136 HTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFA-KSVIGTPEFMAPEMY-E 193 Query: 194 SSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQA 253 Y VD+++ G EM + + + Q+ + + P Sbjct: 194 EHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPA-------------- 239 Query: 254 FHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQD 302 F D K+++ C+ N ++R+S L+H +F + Sbjct: 240 ----------SFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAE 278 >4WUA-A nrPDB Length = 401 Score = 200 bits (509), Expect = 7e-52, Method: Composition-based stats. Identities = 89/371 (23%), Positives = 150/371 (40%), Gaps = 85/371 (22%) Query: 9 ADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHL 68 + +Y + ++G G + V+ + D++ G +FVA+K V+ E + + E+ +L+ + Sbjct: 39 FNGRYHVIRKLGWGHFSTVWLSWDIQ-GKKFVAMKVVKSA---EHYTETALDEIRLLKSV 94 Query: 69 ETFEHPN------VVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETI 122 + PN VV+L D +S T + +VFE + L ++ K G+P + Sbjct: 95 RNSD-PNDPNREMVVQLLDDFKISGV-NGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCV 152 Query: 123 KDMMFQLLRGLDFLHSH-RVVHRDLKPQNILVT--------------------------- 154 K ++ Q+L+GLD+LH+ R++H D+KP+NIL++ Sbjct: 153 KKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGS 212 Query: 155 ----------------------SSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLL 192 ++K+AD G A T + T YR+ EVL+ Sbjct: 213 AVSTAPATAGNFLVNPLEPKNAEKLKVKIADLGNACWVH--KHFTEDIQTRQYRSLEVLI 270 Query: 193 QSSYATPVDLWSVGCIFAEMFRRKPLFRGSS------DVDQLGKILDVIGLPGEEDW--- 243 S Y TP D+WS C+ E+ LF S D D + I++++G + Sbjct: 271 GSGYNTPADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAG 330 Query: 244 ---PRDVALPRQAFHSKSAQPI-------EKFVTDIDELG--KDLLLKCLTFNPAKRISA 291 H +P EK+ +E D LL L P KR +A Sbjct: 331 KYSKEFFTKKGDLKHITKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATA 390 Query: 292 YSALSHPYFQD 302 L HP+ Sbjct: 391 AECLRHPWLNS 401 >4AT3-A nrPDB Length = 299 Score = 200 bits (509), Expect = 7e-52, Method: Composition-based stats. Identities = 69/313 (22%), Positives = 122/313 (38%), Gaps = 58/313 (18%) Query: 15 CVAEIGEGAYGKVFKARDL----KNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 E+GEGA+GKVF A + VA+K ++ + RE +L +L+ Sbjct: 17 LKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLK--DASDNARKDFHREAELLTNLQ- 73 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDK-----------VPEPGVP 118 H ++V+ + VC L +VFE++ DL +L P + Sbjct: 74 --HEHIVKFYGVCV-----EGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELT 126 Query: 119 TETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY---SFQMA 175 + + Q+ G+ +L S VHRDL +N LV + +K+ DFG++R + Sbjct: 127 QSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRV 186 Query: 176 LTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILDV 234 ++ + + PE ++ + T D+WS+G + E+F K + S+ + + I Sbjct: 187 GGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQG 246 Query: 235 IGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSA 294 L P++V +L+L C P R + Sbjct: 247 RVLQRPRTCPQEV--------------------------YELMLGCWQREPHMRKNIKGI 280 Query: 295 LSHPYFQDLERCK 307 H Q+L + Sbjct: 281 --HTLLQNLAKAS 291 >5EG3-A nrPDB Length = 334 Score = 200 bits (509), Expect = 7e-52, Method: Composition-based stats. Identities = 64/316 (20%), Positives = 127/316 (40%), Gaps = 59/316 (18%) Query: 6 LCRADQQYECVAEIGEGAYGKVFKA------RDLKNGGRFVALKRVRVQTGEEGMPLSTI 59 + +GEGA+G+V A +D VA+K ++ E+ + + Sbjct: 30 WEFPRDKLTLGKPLGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLS-DLV 88 Query: 60 REVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLD-------- 110 E+ +++ + +H N++ L CT ++ L ++ + +L YL Sbjct: 89 SEMEMMKMIG--KHKNIINLLGACT-----QDGPLYVIVAYASKGNLREYLRARRPPGME 141 Query: 111 ------KVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADF 164 +VPE + + + +QL RG+++L S + +HRDL +N+LVT + +K+ADF Sbjct: 142 LSPDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADF 201 Query: 165 GLARIYS---FQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFR 220 GLAR + F T+ + + + APE L Y D+WS G + E+F + Sbjct: 202 GLARDINNIDFFKETTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYP 261 Query: 221 GSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKC 280 G + + + + + ++ + ++ C Sbjct: 262 GIPVEELFKLLKEGHRMDKPANCTNELYM--------------------------MMRDC 295 Query: 281 LTFNPAKRISAYSALS 296 P++R + + Sbjct: 296 WHAVPSQRPTFKQLVE 311 >4UYA-A nrPDB Length = 340 Score = 200 bits (508), Expect = 1e-51, Method: Composition-based stats. Identities = 70/300 (23%), Positives = 117/300 (39%), Gaps = 54/300 (18%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMP--LSTIREVAVLRHL 68 ++ E IG G +G+V++A G+ VA+K R ++ S RE + L Sbjct: 26 ERLELKELIGAGGFGQVYRATW---QGQEVAVKAARQDPEQDAAAAAESVRREARLFAML 82 Query: 69 ETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQ 128 HPN++ L VC ++ L LV E + +P + + Q Sbjct: 83 R---HPNIIELRGVCL-----QQPHLCLVLEFARGGALN--RALAGRRIPPHVLVNWAVQ 132 Query: 129 LLRGLDFLHSHR---VVHRDLKPQNILVTS--------SGQIKLADFGLARIYSFQMALT 177 + RG+ +LH ++HRDLK NIL+ + +K+ DFGLAR + + Sbjct: 133 IARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTKMA 192 Query: 178 SVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQ-LGKILDVIG 236 + + APEV+ S ++ D+WS G + E+ + +RG + G ++ + Sbjct: 193 TA-GAYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLT 251 Query: 237 LPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALS 296 LP P K L+ +C +P R S L Sbjct: 252 LPIPSTCPE-------------------------PFAK-LMKECWQQDPHIRPSFALILE 285 >5O2C-A nrPDB Length = 380 Score = 199 bits (507), Expect = 1e-51, Method: Composition-based stats. Identities = 71/289 (24%), Positives = 126/289 (43%), Gaps = 37/289 (12%) Query: 18 EIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVV 77 E+G GA+ V+K D + VA ++ + + E +L+ L+ HPN+V Sbjct: 32 ELGRGAFKTVYKGLDTETWVE-VAWCELQDRKLTKAEQQRFKEEAEMLKGLQ---HPNIV 87 Query: 78 RLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFL 136 R +D ++ + LV E + L TYL + + + ++ Q+L+GL FL Sbjct: 88 RFYDSWESILKGKKC-IVLVTELMTSGTLKTYLKRFK--VMKPKVLRSWCRQILKGLQFL 144 Query: 137 HSHR--VVHRDLKPQNILVTS-SGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQ 193 H+ ++HRDLK NI +T +G +K+ D GLA + A SV+ T + APE+ + Sbjct: 145 HTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFA-KSVIGTPEFMAPEMY-E 202 Query: 194 SSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQA 253 Y VD+++ G EM + + + Q+ + + P Sbjct: 203 EHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPA-------------- 248 Query: 254 FHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQD 302 F D K+++ C+ N ++R+S L+H +F + Sbjct: 249 ----------SFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAE 287 >4KIK-B nrPDB Length = 677 Score = 199 bits (506), Expect = 1e-51, Method: Composition-based stats. Identities = 73/289 (25%), Positives = 118/289 (40%), Gaps = 24/289 (8%) Query: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 +E +G G +G V + + G +A+K+ R Q E+ ++R L Sbjct: 21 WEMKERLGTGGFGNVIR-WHNQETGEQIAIKQCR-QELSPRNRERWCLEIQIMRRL---T 75 Query: 73 HPNVVRLFDVCTVSRTDRETKL-TLVFEHV-DQDLTTYLDKVPEP-GVPTETIKDMMFQL 129 HPNVV DV + L L E+ DL YL++ G+ I ++ + Sbjct: 76 HPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDI 135 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQI---KLADFGLARIYSFQMALTSVVVTLWYR 186 L +LH +R++HRDLKP+NI++ Q K+ D G A+ TS V TL Y Sbjct: 136 ASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYL 195 Query: 187 APEVLLQSSYATPVDLWSVGCIFAEMFRRKPLF-RGSSDVDQLGKILDVIGLPGEEDWPR 245 APE+L Q Y VD WS G + E F V K+ + Sbjct: 196 APELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEV-------- 247 Query: 246 DVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLK----CLTFNPAKRIS 290 D+ + + + +++ + + L K L ++P +R + Sbjct: 248 DIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGT 296 >4R7H-A nrPDB Length = 343 Score = 199 bits (506), Expect = 2e-51, Method: Composition-based stats. Identities = 63/321 (19%), Positives = 114/321 (35%), Gaps = 63/321 (19%) Query: 4 DGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGR----FVALKRVRVQTGEEGMPLSTI 59 + + +G GA+GKV +A G VA+K ++ T + + Sbjct: 43 EKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLK-STAHADEKEALM 101 Query: 60 REVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPE---- 114 E+ ++ HL +H N+V L CT + ++ E+ DL +L + E Sbjct: 102 SELKIMSHLG--QHENIVNLLGACT-----HGGPVLVITEYCTYGDLLNFLRRKAEAMLG 154 Query: 115 -----------------PGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSG 157 + + Q+ +G+ FL S +HRD+ +N+L+T+ Sbjct: 155 PSLSPGQDPEGLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGH 214 Query: 158 QIKLADFGLARIYSFQMAL---TSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFR 214 K+ DFGLAR + + + + APE + S Y D+WS G + E+F Sbjct: 215 VAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDSVYTVQSDVWSYGILLWEIFS 274 Query: 215 -RKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELG 273 + G + K++ + + AF K+ Sbjct: 275 LGLNPYPGILVNSKFYKLVK-----------DGYQMAQPAFAPKNIYS------------ 311 Query: 274 KDLLLKCLTFNPAKRISAYSA 294 ++ C P R + Sbjct: 312 --IMQACWALEPTHRPTFQQI 330 >6FEX-A nrPDB Length = 321 Score = 198 bits (505), Expect = 2e-51, Method: Composition-based stats. Identities = 62/326 (19%), Positives = 122/326 (37%), Gaps = 62/326 (19%) Query: 9 ADQQYECVAEIGEGAYGKVFKAR--------------DLKNGG-RFVALKRVRVQTGEEG 53 + ++GEG +G+V +++ G VA+K +R + Sbjct: 14 PRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILR-PDATKN 72 Query: 54 MPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKV 112 ++EV ++ L+ PN++RL VC ++ L ++ ++++ DL +L Sbjct: 73 ARNDFLKEVKIMSRLKD---PNIIRLLGVCV-----QDDPLCMITDYMENGDLNQFLSAH 124 Query: 113 P-----------EPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKL 161 +P + + + Q+ G+ +L + VHRDL +N LV + IK+ Sbjct: 125 QLEDKAAEGAPGDPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKI 184 Query: 162 ADFGLARIY---SFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAE--MFRRK 216 ADFG++R + V+ + + A E +L + T D+W+ G E M R Sbjct: 185 ADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRA 244 Query: 217 PLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDL 276 F +D + + F + Q + +L Sbjct: 245 QPFGQLTDEQVIEN-------------------AGEFFRDQGRQVYLSRPPACPQGLYEL 285 Query: 277 LLKCLTFNPAKRISAYSALSHPYFQD 302 +L+C + +R H + + Sbjct: 286 MLRCWSRESEQRPPFSQL--HRFLAE 309 >3QUP-A nrPDB Length = 323 Score = 198 bits (505), Expect = 2e-51, Method: Composition-based stats. Identities = 66/325 (20%), Positives = 125/325 (38%), Gaps = 50/325 (15%) Query: 2 EKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFV--ALKRVRVQTGEEGMPLSTI 59 + + + +QQ+ +G+G +G V +A+ + G FV A+K ++ + Sbjct: 14 KLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFL 73 Query: 60 REVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKL-TLVFEHVD-QDLTTYLDKVP---- 113 RE A ++ F+HP+V +L V SR + ++ + DL +L Sbjct: 74 REAACMKE---FDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGEN 130 Query: 114 EPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQ 173 +P +T+ M + G+++L S +HRDL +N ++ + +ADFGL+R Sbjct: 131 PFNLPLQTLVRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSG 190 Query: 174 MALTSVVVT---LWYRAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLG 229 + + + A E L + Y D+W+ G E+ + + G + + Sbjct: 191 DYYRQGCASKLPVKWLALESLADNLYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYN 250 Query: 230 KILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRI 289 ++ L + E DL+ +C + +P +R Sbjct: 251 YLIGGNRLKQPPECM--------------------------EEVYDLMYQCWSADPKQRP 284 Query: 290 SAYSALSHPYFQDLERCKENLDSHL 314 S F L EN+ HL Sbjct: 285 S---------FTCLRMELENILGHL 300 >6DBN-A nrPDB Length = 316 Score = 198 bits (505), Expect = 2e-51, Method: Composition-based stats. Identities = 75/298 (25%), Positives = 134/298 (44%), Gaps = 28/298 (9%) Query: 8 RADQQY-ECVAEIGEGAYGKVFKAR---DLKNGGRFVALKRVRVQTGEEGMPLSTIREVA 63 ++++ + + ++GEG +GKV R + N G VA+K ++ ++G + +E+ Sbjct: 31 HFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIA-DLKKEIE 89 Query: 64 VLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPGVPTETI 122 +LR+L H N+V+ +CT D + L+ E + L YL K + + Sbjct: 90 ILRNL---YHENIVKYKGICT---EDGGNGIKLIMEFLPSGSLKEYLPKNKNK-INLKQQ 142 Query: 123 KDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVV-- 180 Q+ +G+D+L S + VHRDL +N+LV S Q+K+ DFGL + +V Sbjct: 143 LKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDD 202 Query: 181 --VTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLP 238 +++ APE L+QS + D+WS G E+ SD + L +IG Sbjct: 203 RDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLT-----YCDSDSSPMALFLKMIGPT 257 Query: 239 GEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALS 296 + + + R K + + + + L+ KC F P+ R S + + Sbjct: 258 HGQ-----MTVTRLVNTLKEGKRLPC-PPNCPDEVYQLMRKCWEFQPSNRTSFQNLIE 309 >1K9A-A nrPDB Length = 450 Score = 198 bits (504), Expect = 2e-51, Method: Composition-based stats. Identities = 57/300 (19%), Positives = 115/300 (38%), Gaps = 47/300 (15%) Query: 3 KDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREV 62 + G ++ + + IG+G +G V G VA+K ++ + + + E Sbjct: 185 RSGWALNMKELKLLQTIGKGEFGDVMLGDYR---GNKVAVKCIK----NDATAQAFLAEA 237 Query: 63 AVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPGVPTET 121 +V+ L H N+V+L V + + L +V E++ L YL + + Sbjct: 238 SVMTQLR---HSNLVQLLGVIV----EEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDC 290 Query: 122 IKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVV 181 + + +++L + VHRDL +N+LV+ K++DFGL + S + + Sbjct: 291 LLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ--DTGKL 348 Query: 182 TLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILDVIGLPGE 240 + + APE L + ++T D+WS G + E++ + + D + ++ + Sbjct: 349 PVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAP 408 Query: 241 EDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSA---LSH 297 + P D++ C + A R + L H Sbjct: 409 DGCP--------------------------PAVYDVMKNCWHLDAATRPTFLQLREQLEH 442 >5HIE-A nrPDB Length = 302 Score = 198 bits (504), Expect = 2e-51, Method: Composition-based stats. Identities = 64/300 (21%), Positives = 121/300 (40%), Gaps = 45/300 (15%) Query: 3 KDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREV 62 D D Q IG G++G V+K + + VA+K + Q + + EV Sbjct: 28 SDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD----VAVKMLTPQQLQ-----AFKNEV 78 Query: 63 AVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETI 122 VLR H N++ T + +L +V + + + + E + Sbjct: 79 GVLRK---TRHVNILLFMGYST------KPQLAIVTQWCEGSSLYHHLHIIETKFEMIKL 129 Query: 123 KDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARI---YSFQMALTSV 179 D+ Q +G+D+LH+ ++HRDLK NI + +K+ DFGLA + +S + Sbjct: 130 IDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQL 189 Query: 180 VVTLWYRAPEVLL---QSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIG 236 ++ + APEV+ ++ Y+ D+++ G + E+ + + ++ DQ+ I V Sbjct: 190 SGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQI--IFMVGR 247 Query: 237 LPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALS 296 D + K ++ + K L+ +CL +R L+ Sbjct: 248 GYLSPD-------------------LSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILA 288 >6CCF-A nrPDB Length = 290 Score = 198 bits (504), Expect = 2e-51, Method: Composition-based stats. Identities = 78/320 (24%), Positives = 129/320 (40%), Gaps = 62/320 (19%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGM---------------- 54 QY+ +EIG+GAYG V A + ++ R A+K + + + Sbjct: 5 NQYKLQSEIGKGAYGVVRLAYN-ESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQG 63 Query: 55 --------PLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLT 106 +E+A+L+ L +H NVV+L +V E L LVF+ + + Sbjct: 64 GPAKQLLPLERVYQEIAILKKL---DHVNVVKLIEVLDDPA---EDNLYLVFDLLRKG-- 115 Query: 107 TYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGL 166 ++ + E + + ++ GL++LH ++VHRD+KP N+L+ G +K+ADFG+ Sbjct: 116 PVMEVPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGV 175 Query: 167 ARIYS-FQMALTSVVVTLWYRAPEVLLQSS---YATPVDLWSVGCIFAEMFRRKPLFRGS 222 + + L+S T + APE + S +D+W+ G K F Sbjct: 176 SNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDD 235 Query: 223 SDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLT 282 + KI + + EE +I E KDL+LK L Sbjct: 236 FILALHRKIKNEPVVFPEE-------------------------PEISEELKDLILKMLD 270 Query: 283 FNPAKRISAYSALSHPYFQD 302 NP RI HP+ Sbjct: 271 KNPETRIGVPDIKLHPWVTK 290 >4OLI-A nrPDB Length = 645 Score = 198 bits (504), Expect = 3e-51, Method: Composition-based stats. Identities = 70/316 (22%), Positives = 120/316 (37%), Gaps = 37/316 (11%) Query: 11 QQY-ECVAEIGEGAYGKVFK-ARDLKN--GGRFVALKRVRVQTGEEGMPLSTIREVAVLR 66 ++Y + + ++GEG +GKV D N G VA+K ++ G + +E+ +LR Sbjct: 352 KRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQ-HRSGWKQEIDILR 410 Query: 67 HLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPGVPTETIKDM 125 L H ++++ C E L LV E+V L YL P + + Sbjct: 411 TL---YHEHIIKYKGCCEDQG---EKSLQLVMEYVPLGSLRDYL---PRHSIGLAQLLLF 461 Query: 126 MFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVV----V 181 Q+ G+ +LHS +HR+L +N+L+ + +K+ DFGLA+ V Sbjct: 462 AQQICEGMAYLHSQHYIHRNLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDS 521 Query: 182 TLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLP-GE 240 +++ APE L + + D+WS G E+ S K L++IG+ G+ Sbjct: 522 PVFWYAPECLKEYKFYYASDVWSFGVTLYELLT-----HCDSSQSPPTKFLELIGIAQGQ 576 Query: 241 EDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 R L + L+ C + R + + Sbjct: 577 MTVLRLTELLERGERLPRP-------DKCPCEVYHLMKNCWETEASFRPTFENL-----I 624 Query: 301 QDLERCKENLDSHLPP 316 L+ E P Sbjct: 625 PILKTVHEKYQGQAPS 640 Score = 89.2 bits (220), Expect = 2e-18, Method: Composition-based stats. Identities = 56/310 (18%), Positives = 103/310 (33%), Gaps = 54/310 (17%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLE 69 ++ ++ +G+G V++ R G ++ + VL+ L+ Sbjct: 44 QKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLD 103 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKL-------------TLVFEHVDQDLTTYLDKVPEPG 116 H + ++ ++ T L +V E+V+ + Sbjct: 104 PSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGH 163 Query: 117 VPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQ-------IKLADFGLARI 169 VP + QL L +L + +VH ++ +NIL+ G IKL+D G+ Sbjct: 164 VPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLG 223 Query: 170 YSFQMALTSVVVTLWYRAPEVLLQS--SYATPVDLWSVGCIFAEM-FRRKPLFRGSSDVD 226 + + + APE L S +T +D W G E+ F + + S + Sbjct: 224 ALSREERVERIP---WLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSE 280 Query: 227 QLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPA 286 E + R LP +L L +CLT+ P Sbjct: 281 ------------KEHFYQRQHRLPE---------------PSCPQLAT-LTSQCLTYEPT 312 Query: 287 KRISAYSALS 296 +R S + L Sbjct: 313 QRPSFRTILR 322 >4H1J-A nrPDB Length = 293 Score = 198 bits (504), Expect = 3e-51, Method: Composition-based stats. Identities = 59/293 (20%), Positives = 114/293 (38%), Gaps = 43/293 (14%) Query: 8 RADQQYECVAEIGEGAYGKVFKARDLKNGGRF--VALKRVRVQTGEEGMPLSTIREVAVL 65 A + +GEG +G+V++ + G VA+K + + + E ++ Sbjct: 21 IAREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDN-KEKFMSEAVIM 79 Query: 66 RHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFE-HVDQDLTTYLDKVPEPGVPTETIKD 124 ++L +HP++V+L + E ++ E + +L YL++ + T+ Sbjct: 80 KNL---DHPHIVKLIGII------EEEPTWIIMELYPYGELGHYLERNKN-SLKVLTLVL 129 Query: 125 MMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVV--T 182 Q+ + + +L S VHRD+ +NILV S +KL DFGL+R + + V Sbjct: 130 YSLQICKAMAYLESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLP 189 Query: 183 LWYRAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILDVIGLPGEE 241 + + +PE + + T D+W E+ K F + D +G + LP + Sbjct: 190 IKWMSPESINFRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPD 249 Query: 242 DWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSA 294 P + L+ +C ++P+ R Sbjct: 250 LCP--------------------------PVLYTLMTRCWDYDPSDRPRFTEL 276 >1LUF-A nrPDB Length = 343 Score = 198 bits (503), Expect = 4e-51, Method: Composition-based stats. Identities = 73/313 (23%), Positives = 127/313 (40%), Gaps = 66/313 (21%) Query: 9 ADQQYECVAEIGEGAYGKVFKAR----DLKNGGRFVALKRVRVQTGEEGMPLSTIREVAV 64 E V +IGEGA+G+VF+AR VA+K ++ + M RE A+ Sbjct: 45 PRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLK-EEASADMQADFQREAAL 103 Query: 65 LRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKV----------- 112 + F++PN+V+L VC V + + L+FE++ DL +L + Sbjct: 104 MAE---FDNPNIVKLLGVCAVGK-----PMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHS 155 Query: 113 -----------PEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKL 161 P + + Q+ G+ +L + VHRDL +N LV + +K+ Sbjct: 156 DLSTRARVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKI 215 Query: 162 ADFGLARIY---SFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKP 217 ADFGL+R + A + + + + PE + + Y T D+W+ G + E+F Sbjct: 216 ADFGLSRNIYSADYYKADGNDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQ 275 Query: 218 LFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLL 277 + G + + + + D L E+ P ++ +L+ Sbjct: 276 PYYGMAHEEVIYYVRDGNILACPENCPLEL--------------------------YNLM 309 Query: 278 LKCLTFNPAKRIS 290 C + PA R S Sbjct: 310 RLCWSKLPADRPS 322 >4XUF-A nrPDB Length = 297 Score = 197 bits (502), Expect = 4e-51, Method: Composition-based stats. Identities = 70/319 (21%), Positives = 119/319 (37%), Gaps = 63/319 (19%) Query: 6 LCRADQQYECVAEIGEGAYGKVFKARDL---KNGGRF-VALKRVRVQTGEEGMPLSTIRE 61 + E +G GA+GKV A K G VA+K ++ + + + + E Sbjct: 4 WEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLK-EKADSSEREALMSE 62 Query: 62 VAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPG---- 116 + ++ L + H N+V L CT+S + L+FE+ DL YL E Sbjct: 63 LKMMTQLGS--HENIVNLLGACTLS-----GPIYLIFEYCCYGDLLNYLRSKREKFSEDE 115 Query: 117 -----------------VPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQI 159 + E + +Q+ +G++FL VHRDL +N+LVT + Sbjct: 116 IEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVV 175 Query: 160 KLADFGLARIY---SFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFR-R 215 K+ DFGLAR S + + + + + APE L + Y D+WS G + E+F Sbjct: 176 KICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLG 235 Query: 216 KPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKD 275 + G K++ + + + Sbjct: 236 VNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYI------------------------- 270 Query: 276 LLLKCLTFNPAKRISAYSA 294 ++ C F+ KR S + Sbjct: 271 IMQSCWAFDSRKRPSFPNL 289 >6BSD-A nrPDB Length = 876 Score = 197 bits (501), Expect = 5e-51, Method: Composition-based stats. Identities = 62/332 (18%), Positives = 121/332 (36%), Gaps = 68/332 (20%) Query: 9 ADQQYECVAEIGEGAYGKVFKAR--------------DLKNGG-RFVALKRVRVQTGEEG 53 + ++GEG +G+V +++ G VA+K +R + Sbjct: 569 PRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILR-PDATKN 627 Query: 54 MPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYL--- 109 ++EV ++ L+ PN++RL VC ++ L ++ ++++ DL +L Sbjct: 628 ARNDFLKEVKIMSRLKD---PNIIRLLGVCV-----QDDPLCMITDYMENGDLNQFLSAH 679 Query: 110 --------------DKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTS 155 P + + + Q+ G+ +L + VHRDL +N LV Sbjct: 680 QLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGE 739 Query: 156 SGQIKLADFGLARIY---SFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAE- 211 + IK+ADFG++R + V+ + + A E +L + T D+W+ G E Sbjct: 740 NFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEV 799 Query: 212 -MFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDID 270 M R F +D + + F + Q Sbjct: 800 LMLCRAQPFGQLTDEQVIEN-------------------AGEFFRDQGRQVYLSRPPACP 840 Query: 271 ELGKDLLLKCLTFNPAKRISAYSALSHPYFQD 302 + +L+L+C + +R H + + Sbjct: 841 QGLYELMLRCWSRESEQRPPFSQL--HRFLAE 870 >5X02-A nrPDB Length = 347 Score = 197 bits (501), Expect = 6e-51, Method: Composition-based stats. Identities = 70/319 (21%), Positives = 119/319 (37%), Gaps = 63/319 (19%) Query: 6 LCRADQQYECVAEIGEGAYGKVFKARDL---KNGGRF-VALKRVRVQTGEEGMPLSTIRE 61 + E +G GA+GKV A K G VA+K ++ + + + + E Sbjct: 43 WEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLK-EKADSSEREALMSE 101 Query: 62 VAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPG---- 116 + ++ L + H N+V L CT+S + L+FE+ DL YL E Sbjct: 102 LKMMTQLGS--HENIVNLLGACTLS-----GPIYLIFEYCCYGDLLNYLRSKREKFSEDE 154 Query: 117 -----------------VPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQI 159 + E + +Q+ +G++FL VHRDL +N+LVT + Sbjct: 155 IEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVV 214 Query: 160 KLADFGLARIY---SFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFR-R 215 K+ DFGLAR S + + + + + APE L + Y D+WS G + E+F Sbjct: 215 KICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLG 274 Query: 216 KPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKD 275 + G K++ + + + Sbjct: 275 VNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYI------------------------- 309 Query: 276 LLLKCLTFNPAKRISAYSA 294 ++ C F+ KR S + Sbjct: 310 IMQSCWAFDSRKRPSFPNL 328 >4UY9-A nrPDB Length = 323 Score = 197 bits (500), Expect = 7e-51, Method: Composition-based stats. Identities = 72/294 (24%), Positives = 117/294 (39%), Gaps = 50/294 (17%) Query: 14 ECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEH 73 IG G +GKV++A + G VA+K R +E + + + +H Sbjct: 12 TLEEIIGIGGFGKVYRAFWI---GDEVAVKAAR-HDPDEDISQTIENVRQEAKLFAMLKH 67 Query: 74 PNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGL 133 PN++ L VC +E L LV E + +P + + + Q+ RG+ Sbjct: 68 PNIIALRGVCL-----KEPNLCLVMEFARGGPLN--RVLSGKRIPPDILVNWAVQIARGM 120 Query: 134 DFLHSHRV---VHRDLKPQNILVT--------SSGQIKLADFGLARIYSFQMALTSVVVT 182 ++LH + +HRDLK NIL+ S+ +K+ DFGLAR + + S T Sbjct: 121 NYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKM-SAAGT 179 Query: 183 LWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQ-LGKILDVIGLPGEE 241 + APEV+ S ++ D+WS G + E+ + FRG + G ++ + LP Sbjct: 180 YAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPS 239 Query: 242 DWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSAL 295 P K L+ C +P R S + L Sbjct: 240 TCPE-------------------------PFAK-LMEDCWNPDPHSRPSFTNIL 267 >5B2L-A nrPDB Length = 324 Score = 197 bits (500), Expect = 7e-51, Method: Composition-based stats. Identities = 69/304 (22%), Positives = 118/304 (38%), Gaps = 41/304 (13%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 E + E+G G G+V+K R + G +A+K++R +E + VL+ + Sbjct: 17 NDLENLGEMGSGTCGQVWKMR-FRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLK---S 72 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130 + P +V+ F T + + E + L K + +P + M ++ Sbjct: 73 HDCPYIVQCFGTFIT-----NTDVFIAMELM-GTSAEKLKKRMQGPIPERILGKMTVAIV 126 Query: 131 RGLDFL-HSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPE 189 + L +L H V+HRD+KP NIL+ GQIKL DFG++ A T Y APE Sbjct: 127 KALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPE 186 Query: 190 VL-----LQSSYATPVDLWSVGCIFAEMFRRKPLFRGS-SDVDQLGKILDVIGLPGEEDW 243 + + Y D+WS+G E+ + ++ +D + L K+L Sbjct: 187 RIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQ---------- 236 Query: 244 PRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDL 303 P+ + + CLT + KR L H + + Sbjct: 237 --------------EEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRY 282 Query: 304 ERCK 307 E + Sbjct: 283 ETLE 286 >3G0E-A nrPDB Length = 336 Score = 197 bits (500), Expect = 8e-51, Method: Composition-based stats. Identities = 66/317 (20%), Positives = 114/317 (35%), Gaps = 60/317 (18%) Query: 6 LCRADQQYECVAEIGEGAYGKVFKARD----LKNGGRFVALKRVRVQTGEEGMPLSTIRE 61 + +G GA+GKV +A + VA+K ++ + + + E Sbjct: 41 WEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLK-PSAHLTEREALMSE 99 Query: 62 VAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPGVPTE 120 + VL +L H N+V L CT+ ++ E+ DL +L + + + ++ Sbjct: 100 LKVLSYLG--NHMNIVNLLGACTIG-----GPTLVITEYCCYGDLLNFLRRKRDSFICSK 152 Query: 121 TIKDMM----------------FQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADF 164 T +M +Q+ +G+ FL S +HRDL +NIL+T K+ DF Sbjct: 153 TSPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDF 212 Query: 165 GLARIYSFQMAL---TSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFR 220 GLAR + + + + APE + Y D+WS G E+F + Sbjct: 213 GLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYP 272 Query: 221 GSS-DVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLK 279 G D I + + E P D++ Sbjct: 273 GMPVDSKFYKMIKEGFRMLSPEHAP--------------------------AEMYDIMKT 306 Query: 280 CLTFNPAKRISAYSALS 296 C +P KR + + Sbjct: 307 CWDADPLKRPTFKQIVQ 323 >3QGY-A nrPDB Length = 286 Score = 197 bits (500), Expect = 8e-51, Method: Composition-based stats. Identities = 65/266 (24%), Positives = 108/266 (40%), Gaps = 20/266 (7%) Query: 14 ECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEH 73 V EIG G +G V L VA+K ++ + E I E V+ L H Sbjct: 30 TFVQEIGSGQFGLVHLGYWLNKDK--VAIKTIKEGSMSED---DFIEEAEVMMKLS---H 81 Query: 74 PNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGL 133 P +V+L+ VC + + LVFE ++ + + ET+ M + G+ Sbjct: 82 PKLVQLYGVCL-----EQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGM 136 Query: 134 DFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY--SFQMALTSVVVTLWYRAPEVL 191 +L V+HRDL +N LV + IK++DFG+ R + T + + +PEV Sbjct: 137 AYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVF 196 Query: 192 LQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALP 250 S Y++ D+WS G + E+F K + S+ + + I L PR + Sbjct: 197 SFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYK----PRLASTH 252 Query: 251 RQAFHSKSAQPIEKFVTDIDELGKDL 276 + + + L + L Sbjct: 253 VYQIMNHCWKERPEDRPAFSRLLRQL 278 >6DBM-A nrPDB Length = 318 Score = 196 bits (499), Expect = 1e-50, Method: Composition-based stats. Identities = 70/316 (22%), Positives = 120/316 (37%), Gaps = 37/316 (11%) Query: 11 QQY-ECVAEIGEGAYGKVFK-ARDLKN--GGRFVALKRVRVQTGEEGMPLSTIREVAVLR 66 ++Y + + ++GEG +GKV D N G VA+K ++ G + +E+ +LR Sbjct: 30 KRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAGPQ-HRSGWKQEIDILR 88 Query: 67 HLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPGVPTETIKDM 125 L H ++++ C + L LV E+V L YL P + + Sbjct: 89 TL---YHEHIIKYKGCCEDAGAAS---LQLVMEYVPLGSLRDYL---PRHSIGLAQLLLF 139 Query: 126 MFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVV----V 181 Q+ G+ +LHS +HRDL +N+L+ + +K+ DFGLA+ V Sbjct: 140 AQQICEGMAYLHSQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDS 199 Query: 182 TLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLP-GE 240 +++ APE L + + D+WS G E+ S K L++IG+ G+ Sbjct: 200 PVFWYAPECLKEYKFYYASDVWSFGVTLYELLT-----HCDSSQSPPTKFLELIGIAQGQ 254 Query: 241 EDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 R L + L+ C + R + + Sbjct: 255 MTVLRLTELLERGERLPRP-------DKCPAEVYHLMKNCWETEASFRPTFENL-----I 302 Query: 301 QDLERCKENLDSHLPP 316 L+ E P Sbjct: 303 PILKTVHEKYQGQAPS 318 >1BYG-A nrPDB Length = 278 Score = 196 bits (499), Expect = 1e-50, Method: Composition-based stats. Identities = 57/300 (19%), Positives = 115/300 (38%), Gaps = 47/300 (15%) Query: 3 KDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREV 62 + G ++ + + IG+G +G V G VA+K ++ + + + E Sbjct: 13 RSGWALNMKELKLLQTIGKGEFGDVMLGDYR---GNKVAVKCIK----NDATAQAFLAEA 65 Query: 63 AVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPGVPTET 121 +V+ L H N+V+L V + + L +V E++ L YL + + Sbjct: 66 SVMTQLR---HSNLVQLLGVIV----EEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDC 118 Query: 122 IKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVV 181 + + +++L + VHRDL +N+LV+ K++DFGL + S + + Sbjct: 119 LLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ--DTGKL 176 Query: 182 TLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILDVIGLPGE 240 + + APE L + ++T D+WS G + E++ + + D + ++ + Sbjct: 177 PVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAP 236 Query: 241 EDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSA---LSH 297 + P +++ C + A R S L H Sbjct: 237 DGCP--------------------------PAVYEVMKNCWHLDAAMRPSFLQLREQLEH 270 >5KMM-A nrPDB Length = 329 Score = 196 bits (498), Expect = 1e-50, Method: Composition-based stats. Identities = 69/299 (23%), Positives = 111/299 (37%), Gaps = 58/299 (19%) Query: 18 EIGEGAYGKVFKARDL----KNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEH 73 E+GEGA+GKVF A + VA+K ++ E RE +L L+ H Sbjct: 42 ELGEGAFGKVFLAECHNLLPEQDKMLVAVKALK--EASESARQDFQREAELLTMLQ---H 96 Query: 74 PNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDK-------------VPEPGVPT 119 ++VR F VCT R L +VFE++ DL +L V + Sbjct: 97 QHIVRFFGVCTEGR-----PLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGL 151 Query: 120 ETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY---SFQMAL 176 + + Q+ G+ +L VHRDL +N LV +K+ DFG++R + Sbjct: 152 GQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVG 211 Query: 177 TSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILDVI 235 ++ + + PE +L + T D+WS G + E+F K + S+ + + I Sbjct: 212 GRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGR 271 Query: 236 GLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSA 294 L P ++ C P +R S Sbjct: 272 ELERPRACP--------------------------PEVYAIMRGCWQREPQQRHSIKDV 304 >5TUR-A nrPDB Length = 404 Score = 196 bits (498), Expect = 1e-50, Method: Composition-based stats. Identities = 69/313 (22%), Positives = 119/313 (38%), Gaps = 51/313 (16%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPL----STIREVAVL 65 + QY+ +G G +G V+ + + VA+K V + L EV +L Sbjct: 126 ESQYQVGPLLGSGGFGSVYSGIRVSDN-LPVAIKHVEKDRISDWGELPNGTRVPMEVVLL 184 Query: 66 RHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD--QDLTTYLDKVPEPGVPTETIK 123 + + + V+RL D +R L+ E + QDL ++ + E + Sbjct: 185 KKVSSGFS-GVIRLLDWF-----ERPDSFVLILERPEPVQDLFDFI--TERGALQEELAR 236 Query: 124 DMMFQLLRGLDFLHSHRVVHRDLKPQNILVT-SSGQIKLADFGLARIYSFQMALTSVVVT 182 +Q+L + H+ V+HRD+K +NIL+ + G++KL DFG + T T Sbjct: 237 SFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK-DTVYTDFDGT 295 Query: 183 LWYRAPEVLLQSSY-ATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEE 241 Y PE + Y +WS+G + +M F +E Sbjct: 296 RVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFE------------------HDE 337 Query: 242 DWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQ 301 + R RQ + + L+ CL P+ R + +HP+ Q Sbjct: 338 EIIRGQVFFRQ---------------RVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQ 382 Query: 302 DLERCKENLDSHL 314 D+ +E + HL Sbjct: 383 DVLLPQETAEIHL 395 >3ORP-A nrPDB Length = 311 Score = 195 bits (497), Expect = 2e-50, Method: Composition-based stats. Identities = 64/273 (23%), Positives = 116/273 (42%), Gaps = 9/273 (3%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLE 69 +YE +G G +V ARDL++ R VA+K +R + P +R ++ Sbjct: 11 SDRYELGEILGFGGMSEVHLARDLRD-HRDVAVKVLRADLARD--PSFYLRFRREAQNAA 67 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQL 129 HP +V ++D +V E+VD + P + + +++ Sbjct: 68 ALNHPAIVAVYDTGEAETPAGPLP-YIVMEYVDGVTLRDIVHTEGP-MTPKRAIEVIADA 125 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTS----VVVTLWY 185 + L+F H + ++HRD+KP NI+++++ +K+ DFG+AR + + V+ T Y Sbjct: 126 CQALNFSHQNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGTAQY 185 Query: 186 RAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPR 245 +PE S D++S+GC+ E+ +P F G S V + + +P Sbjct: 186 LSPEQARGDSVDARSDVYSLGCVLYEVLTGEPPFTGDSPVSVAYQHVREDPIPPSARHEG 245 Query: 246 DVALPRQAFHSKSAQPIEKFVTDIDELGKDLLL 278 A A+ E E+ DL+ Sbjct: 246 LSADLDAVVLKALAKNPENRYQTAAEMRADLVR 278 >3BGP-A nrPDB Length = 333 Score = 195 bits (496), Expect = 2e-50, Method: Composition-based stats. Identities = 69/313 (22%), Positives = 119/313 (38%), Gaps = 51/313 (16%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPL----STIREVAVL 65 + QY+ +G G +G V+ + + VA+K V + L EV +L Sbjct: 55 ESQYQVGPLLGSGGFGSVYSGIRVSDN-LPVAIKHVEKDRISDWGELPNGTRVPMEVVLL 113 Query: 66 RHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD--QDLTTYLDKVPEPGVPTETIK 123 + + + V+RL D +R L+ E + QDL ++ + E + Sbjct: 114 KKVSSGFS-GVIRLLDWF-----ERPDSFVLILERPEPVQDLFDFI--TERGALQEELAR 165 Query: 124 DMMFQLLRGLDFLHSHRVVHRDLKPQNILVT-SSGQIKLADFGLARIYSFQMALTSVVVT 182 +Q+L + H+ V+HRD+K +NIL+ + G++KL DFG + T T Sbjct: 166 SFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK-DTVYTDFDGT 224 Query: 183 LWYRAPEVLLQSSY-ATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEE 241 Y PE + Y +WS+G + +M F +E Sbjct: 225 RVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFE------------------HDE 266 Query: 242 DWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQ 301 + R RQ + + L+ CL P+ R + +HP+ Q Sbjct: 267 EIIRGQVFFRQ---------------RVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQ 311 Query: 302 DLERCKENLDSHL 314 D+ +E + HL Sbjct: 312 DVLLPQETAEIHL 324 >3DTC-A nrPDB Length = 271 Score = 195 bits (495), Expect = 3e-50, Method: Composition-based stats. Identities = 71/294 (24%), Positives = 116/294 (39%), Gaps = 50/294 (17%) Query: 14 ECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEH 73 IG G +GKV++A + G VA+K R +E + + + +H Sbjct: 10 TLEEIIGIGGFGKVYRAFWI---GDEVAVKAAR-HDPDEDISQTIENVRQEAKLFAMLKH 65 Query: 74 PNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGL 133 PN++ L VC +E L LV E + +P + + + Q+ RG+ Sbjct: 66 PNIIALRGVCL-----KEPNLCLVMEFARGGPLN--RVLSGKRIPPDILVNWAVQIARGM 118 Query: 134 DFLHSHRV---VHRDLKPQNILVT--------SSGQIKLADFGLARIYSFQMALTSVVVT 182 ++LH + +HRDLK NIL+ S+ +K+ DFGLAR + + S Sbjct: 119 NYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKM-SAAGA 177 Query: 183 LWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQ-LGKILDVIGLPGEE 241 + APEV+ S ++ D+WS G + E+ + FRG + G ++ + LP Sbjct: 178 YAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPS 237 Query: 242 DWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSAL 295 P K L+ C +P R S + L Sbjct: 238 TCPE-------------------------PFAK-LMEDCWNPDPHSRPSFTNIL 265 >5X5O-A nrPDB Length = 310 Score = 195 bits (495), Expect = 3e-50, Method: Composition-based stats. Identities = 61/280 (21%), Positives = 112/280 (40%), Gaps = 51/280 (18%) Query: 20 GEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRL 79 G G++G V++A+ + VA+K++ L +E +L L H N+++ Sbjct: 24 GGGSFGSVYRAKWISQDKE-VAVKKL----------LKIEKEAEILSVLS---HRNIIQF 69 Query: 80 FDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHS 138 + V +V E+ L Y++ + + I + +G+ +LH Sbjct: 70 YGVIL-----EPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHM 124 Query: 139 H---RVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSS 195 +V+HRDLK +N+++ + G +K+ DFG +R ++ + S+V T + APEV+ Sbjct: 125 EAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHM-SLVGTFPWMAPEVIQSLP 183 Query: 196 YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQ-LGKILDVIGLPGEEDWPRDVALPRQAF 254 + D +S G + EM R+ F+G + + L PR A Sbjct: 184 VSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFA------ 237 Query: 255 HSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSA 294 +LL +C + KR S Sbjct: 238 --------------------ELLHQCWEADAKKRPSFKQI 257 >4EQM-A nrPDB Length = 294 Score = 195 bits (495), Expect = 3e-50, Method: Composition-based stats. Identities = 69/281 (24%), Positives = 123/281 (43%), Gaps = 15/281 (5%) Query: 8 RADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMP-LSTIREVAVLR 66 +++Y+ V ++G G V+ A D + VA+K + + E+ REV Sbjct: 8 IINERYKIVDKLGGGGMSTVYLAEDTILNIK-VAIKAIFIPPREKEETLKRFEREV---H 63 Query: 67 HLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDM 125 + H N+V + DV + + LV E+++ L+ Y++ + +T + Sbjct: 64 NSSQLSHQNIVSMIDV-----DEEDDCYYLVMEYIEGPTLSEYIES--HGPLSVDTAINF 116 Query: 126 MFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQ--MALTSVVVTL 183 Q+L G+ H R+VHRD+KPQNIL+ S+ +K+ DFG+A+ S V+ T+ Sbjct: 117 TNQILDGIKHAHDMRIVHRDIKPQNILIDSNKTLKIFDFGIAKALSETSLTQTNHVLGTV 176 Query: 184 WYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDW 243 Y +PE + D++S+G + EM +P F G + V K + D Sbjct: 177 QYFSPEQAKGEATDECTDIYSIGIVLYEMLVGEPPFNGETAVSIAIKHIQDSVPNVTTDV 236 Query: 244 PRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFN 284 +D+ ++ + + + KD L L N Sbjct: 237 RKDIPQSLSNVILRATEKDKANRYKTIQEMKDDLSSVLHEN 277 >3ZBF-A nrPDB Length = 322 Score = 195 bits (495), Expect = 3e-50, Method: Composition-based stats. Identities = 63/327 (19%), Positives = 130/327 (39%), Gaps = 61/327 (18%) Query: 9 ADQQYECVAEIGEGAYGKVFKARDLK-----NGGRFVALKRVRVQTGEEGMPLSTIREVA 63 ++ +G GA+G+V++ + +G VA+K ++ + ++ + ++E Sbjct: 31 PREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQ-EKIEFLKEAH 89 Query: 64 VLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVP-----EPGV 117 ++ F HPN+++ VC ++ ++ E ++ DL TYL K P + Sbjct: 90 LMSK---FNHPNILKQLGVCLLNEPQ-----YIILELMEGGDLLTYLRKARMATFYGPLL 141 Query: 118 PTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILV-----TSSGQIKLADFGLARIY-- 170 + D+ + +G +L +HRDL +N LV TS +K+ DFGLAR Sbjct: 142 TLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYK 201 Query: 171 -SFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQL 228 + ++ + + APE L+ + T D+WS G + E+ + S++D L Sbjct: 202 NDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVL 261 Query: 229 GKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKR 288 + L + P D+ +L+ +C P +R Sbjct: 262 NYVQTGGRLEPPRNCPDDLW--------------------------NLMTQCWAQEPDQR 295 Query: 289 ISAY------SALSHPYFQDLERCKEN 309 + + + + + + ++ Sbjct: 296 PTFHRIQDQLQLFRNFFLNSIYKSRDE 322 >4E20-A nrPDB Length = 290 Score = 194 bits (493), Expect = 5e-50, Method: Composition-based stats. Identities = 67/294 (22%), Positives = 115/294 (39%), Gaps = 32/294 (10%) Query: 11 QQY-ECVAEIGEGAYGKVFK-ARDLKN--GGRFVALKRVRVQTGEEGMPLSTIREVAVLR 66 ++Y + + ++GEG +GKV D N G VA+K ++ G + + RE+ +LR Sbjct: 7 KRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQ-LRSGWQREIEILR 65 Query: 67 HLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPGVPTETIKDM 125 L H ++V+ C E + LV E+V L YL P V + Sbjct: 66 TL---YHEHIVKYKGCCEDQG---EKSVQLVMEYVPLGSLRDYL---PRHCVGLAQLLLF 116 Query: 126 MFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVV----V 181 Q+ G+ +LH+ +HR L +N+L+ + +K+ DFGLA+ V Sbjct: 117 AQQICEGMAYLHAQHYIHRALAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDS 176 Query: 182 TLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIG-LPGE 240 +++ APE L + + D+WS G E+ S+ K ++IG G+ Sbjct: 177 PVFWYAPECLKECKFYYASDVWSFGVTLYELLT-----YCDSNQSPHTKFTELIGHTQGQ 231 Query: 241 EDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSA 294 R L + L+ C + R + + Sbjct: 232 MTVLRLTELLERGERLPRP-------DRCPCEIYHLMKNCWETEASFRPTFQNL 278 >4RC3-A nrPDB Length = 289 Score = 194 bits (493), Expect = 5e-50, Method: Composition-based stats. Identities = 69/313 (22%), Positives = 119/313 (38%), Gaps = 51/313 (16%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPL----STIREVAVL 65 + QY+ +G G +G V+ + + VA+K V + L EV +L Sbjct: 11 ESQYQVGPLLGSGGFGSVYSGIRVSDN-LPVAIKHVEKDRISDWGELPNGTRVPMEVVLL 69 Query: 66 RHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD--QDLTTYLDKVPEPGVPTETIK 123 + + + V+RL D +R L+ E + QDL ++ + E + Sbjct: 70 KKVSSGFS-GVIRLLDWF-----ERPDSFVLILERPEPVQDLFDFI--TERGALQEELAR 121 Query: 124 DMMFQLLRGLDFLHSHRVVHRDLKPQNILVT-SSGQIKLADFGLARIYSFQMALTSVVVT 182 +Q+L + H+ V+HRD+K +NIL+ + G++KL DFG + T T Sbjct: 122 SFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK-DTVYTDFDGT 180 Query: 183 LWYRAPEVLLQSSY-ATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEE 241 Y PE + Y +WS+G + +M F +E Sbjct: 181 RVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFE------------------HDE 222 Query: 242 DWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQ 301 + R RQ + + L+ CL P+ R + +HP+ Q Sbjct: 223 EIIRGQVFFRQ---------------RVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQ 267 Query: 302 DLERCKENLDSHL 314 D+ +E + HL Sbjct: 268 DVLLPQETAEIHL 280 >3LLT-A nrPDB Length = 360 Score = 193 bits (492), Expect = 7e-50, Method: Composition-based stats. Identities = 79/340 (23%), Positives = 132/340 (38%), Gaps = 61/340 (17%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLE 69 + + + ++G+G +G+V + + N ++ A+K VR + S E +L+ ++ Sbjct: 34 NNAFLVIRKMGDGTFGRVLLCQHIDN-KKYYAVKVVR---NIKKYTRSAKIEADILKKIQ 89 Query: 70 TFEHPNV--VRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMF 127 + N V+ + L+FE + L + + G E IK Sbjct: 90 NDDINNNNIVKYHGKFMYY-----DHMCLIFEPLGPSLYEIITRNNYNGFHIEDIKLYCI 144 Query: 128 QLLRGLDFLHSHRVVHRDLKPQNILVTS-------------------------SGQIKLA 162 ++L+ L++L + H DLKP+NIL+ S IKL Sbjct: 145 EILKALNYLRKMSLTHTDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRTKSTGIKLI 204 Query: 163 DFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGS 222 DFG A S S++ T YRAPEV+L + D+WS GC+ AE++ LFR Sbjct: 205 DFGCATFKSDYH--GSIINTRQYRAPEVILNLGWDVSSDMWSFGCVLAELYTGSLLFRTH 262 Query: 223 SDVDQLGKILDVIGLPGEE---------------------DWPRDVALPRQAFHSKSAQP 261 ++ L + +I + WP + + H K P Sbjct: 263 EHMEHLAMMESIIQPIPKNMLYEATKTNGSKYVNKDELKLAWPENASSINSIKHVKKCLP 322 Query: 262 IEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQ 301 + K + EL D L L +P R S L H + + Sbjct: 323 LYKIIKH--ELFCDFLYSILQIDPTLRPSPAELLKHKFLE 360 >2W1I-A nrPDB Length = 326 Score = 193 bits (491), Expect = 8e-50, Method: Composition-based stats. Identities = 66/301 (21%), Positives = 128/301 (42%), Gaps = 27/301 (8%) Query: 2 EKDGLCRADQQYECVAEIGEGAYGKVFKARD---LKNGGRFVALKRVRVQTGEEGMPLST 58 ++D ++ + + ++G+G +G V R N G VA+K+++ T E Sbjct: 32 DRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHST--EEHLRDF 89 Query: 59 IREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPGV 117 RE+ +L+ L+ H N+V+ VC + L L+ E++ L YL K E + Sbjct: 90 EREIEILKSLQ---HDNIVKYKGVCYSAGRRN---LKLIMEYLPYGSLRDYLQKHKER-I 142 Query: 118 PTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALT 177 + Q+ +G+++L + R +HRDL +NILV + ++K+ DFGL ++ Sbjct: 143 DHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYY 202 Query: 178 SVV----VTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILD 233 V +++ APE L +S ++ D+WS G + E+F + + Sbjct: 203 KVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFT-----YIEKSKSPPAEFMR 257 Query: 234 VIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYS 293 +IG + + + + +P + ++ +C N +R S Sbjct: 258 MIGNDKQGQMIVFHLIELLKNNGRLPRP-----DGCPDEIYMIMTECWNNNVNQRPSFRD 312 Query: 294 A 294 Sbjct: 313 L 313 >3OMV-A nrPDB Length = 307 Score = 193 bits (491), Expect = 9e-50, Method: Composition-based stats. Identities = 63/292 (21%), Positives = 116/292 (39%), Gaps = 46/292 (15%) Query: 18 EIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVV 77 IG G++G V+K + + VA+K ++V + EVAVLR H N++ Sbjct: 43 RIGSGSFGTVYKGKWHGD----VAVKILKVVDPTPEQFQAFRNEVAVLRK---TRHVNIL 95 Query: 78 RLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLH 137 T + L +V + + V E + D+ Q +G+D+LH Sbjct: 96 LFMGYMT------KDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLH 149 Query: 138 SHRVVHRDLKPQNILVTSSGQIKLADFGLARI---YSFQMALTSVVVTLWYRAPEVLL-- 192 + ++HRD+K NI + +K+ DFGLA + +S + ++ + APEV+ Sbjct: 150 AKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQ 209 Query: 193 -QSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPR 251 + ++ D++S G + E+ + + ++ DQ+ I V D Sbjct: 210 DNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQI--IFMVGRGYASPD--------- 258 Query: 252 QAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRI------SAYSALSH 297 + K + + K L+ C+ +R S+ L H Sbjct: 259 ----------LSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQH 300 >1ZXE-A nrPDB Length = 303 Score = 193 bits (490), Expect = 1e-49, Method: Composition-based stats. Identities = 77/318 (24%), Positives = 130/318 (40%), Gaps = 56/318 (17%) Query: 7 CRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLR 66 R +E +A +G+GA+G+V KAR+ + R+ A+K++R E + + EV +L Sbjct: 2 LRYASDFEEIAVLGQGAFGQVVKARNALDS-RYYAIKKIRHT---EEKLSTILSEVMLL- 56 Query: 67 HLETFEHPNVVRLFDVCTVSRT--------DRETKLTLVFEHVDQDLTTYLDKVPEPGVP 118 + H VVR + R +++ L + E+ + L Sbjct: 57 --ASLNHQYVVRYYAAWLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQ 114 Query: 119 TETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYS------- 171 + + Q+L L ++HS ++HR+LKP NI + S +K+ DFGLA+ Sbjct: 115 RDEYWRLFRQILEALSYIHSQGIIHRNLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILK 174 Query: 172 --------FQMALTSVVVTLWYRAPEVLLQ-SSYATPVDLWSVGCIFAEMFRRKPLFRGS 222 LTS + T Y A EVL Y +D++S+G IF EM P G Sbjct: 175 LDSQNLPGSSDNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMI--YPFSTGM 232 Query: 223 SDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLT 282 V+ L K+ V S + F + ++ K ++ + Sbjct: 233 ERVNILKKLRSV-----------------------SIEFPPDFDDNKMKVEKKIIRLLID 269 Query: 283 FNPAKRISAYSALSHPYF 300 +P KR A + L+ + Sbjct: 270 HDPNKRPGARTLLNSGWL 287 >3IO7-A nrPDB Length = 313 Score = 192 bits (488), Expect = 2e-49, Method: Composition-based stats. Identities = 65/293 (22%), Positives = 125/293 (42%), Gaps = 27/293 (9%) Query: 10 DQQYECVAEIGEGAYGKVFKARD---LKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLR 66 ++ + + ++G+G +G V R N G VA+K+++ T E RE+ +L+ Sbjct: 27 ERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHST--EEHLRDFEREIEILK 84 Query: 67 HLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPGVPTETIKDM 125 L+ H N+V+ VC + L L+ E++ L YL K E + + Sbjct: 85 SLQ---HDNIVKYKGVCYSAGRRN---LKLIMEYLPYGSLRDYLQKHKER-IDHIKLLQY 137 Query: 126 MFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVV----V 181 Q+ +G+++L + R +HRDL +NILV + ++K+ DFGL ++ V Sbjct: 138 TSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGES 197 Query: 182 TLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEE 241 +++ APE L +S ++ D+WS G + E+F + + +IG + Sbjct: 198 PIFWYAPESLTESKFSVASDVWSFGVVLYELFT-----YIEKSKSPPAEFMRMIGNDKQG 252 Query: 242 DWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSA 294 + + + +P + ++ +C N +R S Sbjct: 253 QMIVFHLIELLKNNGRLPRP-----DGCPDEIYMIMTECWNNNVNQRPSFRDL 300 >5AMN-A nrPDB Length = 299 Score = 192 bits (487), Expect = 2e-49, Method: Composition-based stats. Identities = 62/300 (20%), Positives = 120/300 (40%), Gaps = 31/300 (10%) Query: 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGR----FVALKRVRVQTGEEGMPL 56 +E + +GEG +GKV KA GR VA+K ++ + Sbjct: 13 LEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLK-ENASPSELR 71 Query: 57 STIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVP-- 113 + E VL+ HP+V++L+ C+ ++ L L+ E+ L +L + Sbjct: 72 DLLSEFNVLKQ---VNHPHVIKLYGACS-----QDGPLLLIVEYAKYGSLRGFLRESRKV 123 Query: 114 ------EPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLA 167 E + + +Q+ +G+ +L ++VHRDL +NILV ++K++DFGL+ Sbjct: 124 GPGYPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLS 183 Query: 168 RIY---SFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSS 223 R + + + + + A E L Y T D+WS G + E+ + G Sbjct: 184 RDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIP 243 Query: 224 DVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTF 283 ++ +++ + P + + + + ++ KDL K + Sbjct: 244 P----ERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDL-EKMMVK 298 >5GRN-A nrPDB Length = 356 Score = 192 bits (487), Expect = 2e-49, Method: Composition-based stats. Identities = 69/326 (21%), Positives = 116/326 (35%), Gaps = 73/326 (22%) Query: 9 ADQQYE-------CVAEIGEGAYGKVFKARDLKNGG----RFVALKRVRVQTGEEGMPLS 57 D ++E +G GA+GKV + VA+K ++ T + Sbjct: 37 YDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLK-PTARSSEKQA 95 Query: 58 TIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPE-- 114 + E+ ++ HL H N+V L CT S + ++ E+ DL YL K + Sbjct: 96 LMSELKIMTHLGP--HLNIVNLLGACTKS-----GPIYIITEYCFYGDLVNYLHKNRDSF 148 Query: 115 ----------------------PGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNIL 152 G+ + +Q+ RG++FL S VHRDL +N+L Sbjct: 149 LSHKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVL 208 Query: 153 VTSSGQIKLADFGLARIYSFQMAL---TSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIF 209 + +K+ DFGLAR S + + + APE + + Y T D+WS G + Sbjct: 209 LAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILL 268 Query: 210 AEMFR-RKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTD 268 E+F + G + ++ + Sbjct: 269 WEIFSLGGTPYPGM-------------------------MVDSTFYNKIKSGYRMAKPDH 303 Query: 269 IDELGKDLLLKCLTFNPAKRISAYSA 294 ++++KC P KR S Y Sbjct: 304 ATSEVYEIMVKCWNSEPEKRPSFYHL 329 >3QA8-A nrPDB Length = 676 Score = 192 bits (487), Expect = 3e-49, Method: Composition-based stats. Identities = 65/228 (28%), Positives = 103/228 (45%), Gaps = 12/228 (5%) Query: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 +E +G G +G V + ++ G VA+K+ R + + E+ +++ L Sbjct: 16 WEMKERLGTGGFGYVLRWIH-QDTGEQVAIKQCRQELSPKN-RERWCLEIQIMKKL---N 70 Query: 73 HPNVVRLFDVCTVSRTDRETKL-TLVFEHVDQ-DLTTYLDKVPEP-GVPTETIKDMMFQL 129 HPNVV +V + L L E+ + DL YL++ G+ I+ ++ + Sbjct: 71 HPNVVSAREVPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGPIRTLLSDI 130 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQI---KLADFGLARIYSFQMALTSVVVTLWYR 186 L +LH +R++HRDLKP+NI++ Q K+ D G A+ T V TL Y Sbjct: 131 SSALRYLHENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQGELCTEFVGTLQYL 190 Query: 187 APEVLLQSSYATPVDLWSVGCIFAEMFRRKPLF-RGSSDVDQLGKILD 233 APE+L Q Y VD WS G + E F V GK+ + Sbjct: 191 APELLEQKKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHGKVRE 238 >4HZS-A nrPDB Length = 341 Score = 191 bits (486), Expect = 3e-49, Method: Composition-based stats. Identities = 65/294 (22%), Positives = 116/294 (39%), Gaps = 46/294 (15%) Query: 7 CRADQQYECVAEIGEGAYGKVFKARDLKNGGRFV--ALKRVRVQTGEEGMPLS-TIREVA 63 ++ + ++G+G++G V + G+ V A+K ++ + + IREV Sbjct: 8 LIGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVN 67 Query: 64 VLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPGVPTETI 122 + L +H N++RL+ V + +V E L L K + T+ Sbjct: 68 AMHSL---DHRNLIRLYGVVLT------PPMKMVTELAPLGSLLDRLRK-HQGHFLLGTL 117 Query: 123 KDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY----SFQMALTS 178 Q+ G+ +L S R +HRDL +N+L+ + +K+ DFGL R + Sbjct: 118 SRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEH 177 Query: 179 VVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKI-LDVIG 236 V + APE L +++ D W G EMF + + G + L KI + Sbjct: 178 RKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGER 237 Query: 237 LPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRIS 290 LP ED P+D+ +++++C P R + Sbjct: 238 LPRPEDCPQDI--------------------------YNVMVQCWAHKPEDRPT 265 >5TQX-A nrPDB Length = 655 Score = 191 bits (486), Expect = 3e-49, Method: Composition-based stats. Identities = 64/281 (22%), Positives = 110/281 (39%), Gaps = 13/281 (4%) Query: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 +E +G G +G V + + + +A+K R++ + E+ +++ L Sbjct: 10 WEMRERLGTGGFGNVCLYQHRELDLK-IAIKSCRLELSTKN-RERWCHEIQIMKKL---N 64 Query: 73 HPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEP-GVPTETIKDMMFQLL 130 H NVV+ DV L E+ DL L+K G+ I ++ + Sbjct: 65 HANVVKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIG 124 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTS-SGQI--KLADFGLARIYSFQMALTSVVVTLWYRA 187 G+ +LH ++++HRDLKP+NI++ G+I K+ D G A+ T V TL Y A Sbjct: 125 SGIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGELCTEFVGTLQYLA 184 Query: 188 PEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDV 247 PE+ Y VD WS G + E F + + Sbjct: 185 PELFENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPKCIFACEEMS 244 Query: 248 ALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKR 288 R + H + + E ++ L L ++P +R Sbjct: 245 GEVRFSSHLPQPNSLCSLIV---EPMENWLQLMLNWDPQQR 282 >4Y93-A nrPDB Length = 446 Score = 190 bits (484), Expect = 5e-49, Method: Composition-based stats. Identities = 59/270 (21%), Positives = 116/270 (42%), Gaps = 18/270 (6%) Query: 5 GLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAV 64 + + E+G G +G V + G VA+K ++ + E I E V Sbjct: 182 SWEIDPKDLTFLKELGTGQFGVVKYGKWR--GQYDVAIKMIKEGSMSED---EFIEEAKV 236 Query: 65 LRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPGVPTETIK 123 + +L H +V+L+ VCT R + ++ E++ + L YL ++ T+ + Sbjct: 237 MMNLS---HEKLVQLYGVCTKQR-----PIFIITEYMANGCLLNYLREMRHR-FQTQQLL 287 Query: 124 DMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY--SFQMALTSVVV 181 +M + +++L S + +HRDL +N LV G +K++DFG+ R + T Sbjct: 288 EMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGMTRYVLDDEYTSSTGSKF 347 Query: 182 TLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILDVIGLPGE 240 + + +PEVL+ S +++ D+W+ G + E++ K + ++ + I + LP Sbjct: 348 PVKWASPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLPRP 407 Query: 241 EDWPRDVALPRQAFHSKSAQPIEKFVTDID 270 V + + A F + Sbjct: 408 HLASERVYAIMYSCWHEKADERPTFKILLS 437 >3BBT-B nrPDB Length = 328 Score = 190 bits (484), Expect = 6e-49, Method: Composition-based stats. Identities = 63/305 (20%), Positives = 121/305 (39%), Gaps = 21/305 (6%) Query: 14 ECVAEIGEGAYGKVFKARDLKNGGRF---VALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 + V +G GA+G V+K + G VA+K + TG + + + E ++ + Sbjct: 18 KRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKAN-VEFMDEALIMASM-- 74 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130 +HP++VRL VC + LV + + + + ++ + + Q+ Sbjct: 75 -DHPHLVRLLGVCLSPT------IQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIA 127 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVV---TLWYRA 187 +G+ +L R+VHRDL +N+LV S +K+ DFGLAR+ + + + A Sbjct: 128 KGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMA 187 Query: 188 PEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILDVIGLPGEEDWPRD 246 E + + D+WS G E+ + G + + LP D Sbjct: 188 LECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTID 247 Query: 247 VAL---PRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDL 303 V + + S ++ + + +D + L R+ S +FQ+L Sbjct: 248 VYMVMVKCWMIDADSRPKFKELAAEFSRMARD-PQRYLVIQGDDRMKLPSPNDSKFFQNL 306 Query: 304 ERCKE 308 ++ Sbjct: 307 LDEED 311 >5U6C-A nrPDB Length = 315 Score = 190 bits (484), Expect = 6e-49, Method: Composition-based stats. Identities = 63/312 (20%), Positives = 116/312 (37%), Gaps = 49/312 (15%) Query: 15 CVAEIGEGAYGKVFKARDLKNGGR--FVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 +GEG +G V + + G VA+K +++ + + E A ++ F Sbjct: 40 LGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMK---DFS 96 Query: 73 HPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLD----KVPEPGVPTETIKDMMF 127 HPNV+RL VC + K ++ + DL TYL + +P +T+ M Sbjct: 97 HPNVMRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMV 156 Query: 128 QLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY---SFQMALTSVVVTLW 184 + G+++L + +HRDL +N ++ + +ADFGL++ + + + Sbjct: 157 DIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVK 216 Query: 185 YRAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILDVIGLPGEEDW 243 + A E L Y + D+W+ G E+ + G + + +L L ED Sbjct: 217 WIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDC 276 Query: 244 PRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDL 303 ++ +++ C +P R + F L Sbjct: 277 LDEL--------------------------YEIMYSCWRTDPLDRPT---------FSVL 301 Query: 304 ERCKENLDSHLP 315 E L LP Sbjct: 302 RLQLEKLLESLP 313 >4HVI-A nrPDB Length = 314 Score = 190 bits (483), Expect = 7e-49, Method: Composition-based stats. Identities = 64/288 (22%), Positives = 116/288 (40%), Gaps = 26/288 (9%) Query: 10 DQQYECVAEIGEGAYGKVFKARD---LKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLR 66 ++ + ++++G+G +G V R N G VA+K+++ ++ RE+ +L+ Sbjct: 9 ERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQ--RDFQREIQILK 66 Query: 67 HLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMM 126 L + +V+ V S L LV E++ + + + Sbjct: 67 ALHS---DFIVKYRGV---SYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYS 120 Query: 127 FQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVV----VT 182 Q+ +G+++L S R VHRDL +NILV S +K+ADFGLA++ V Sbjct: 121 SQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSP 180 Query: 183 LWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEED 242 +++ APE L + ++ D+WS G + E+F + L ++G Sbjct: 181 IFWYAPESLSDNIFSRQSDVWSFGVVLYELFT-----YCDKSCSPSAEFLRMMGS----- 230 Query: 243 WPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRIS 290 RDV + +L+ C +P R S Sbjct: 231 -ERDVPALSRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPS 277 >4XI2-A nrPDB Length = 446 Score = 190 bits (482), Expect = 9e-49, Method: Composition-based stats. Identities = 63/271 (23%), Positives = 118/271 (43%), Gaps = 20/271 (7%) Query: 5 GLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAV 64 + + E+G G +G V + G VA+K +R + E I E V Sbjct: 181 SWEIDPKDLTFLKELGTGQFGVVKYGKWR--GQYDVAIKMIREGSMSED---EFIEEAKV 235 Query: 65 LRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPGVPTETIK 123 + +L H +V+L+ VCT R + ++ E++ + L YL ++ T+ + Sbjct: 236 MMNLS---HEKLVQLYGVCTKQR-----PIFIITEYMANGCLLNYLREMRHR-FQTQQLL 286 Query: 124 DMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVT- 182 +M + +++L S + +HRDL +N LV G +K++DFGL+R Y TS V + Sbjct: 287 EMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSR-YVLDDEYTSSVGSK 345 Query: 183 --LWYRAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILDVIGLPG 239 + + PEVL+ S +++ D+W+ G + E++ K + ++ + I + L Sbjct: 346 FPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYR 405 Query: 240 EEDWPRDVALPRQAFHSKSAQPIEKFVTDID 270 V + + A F + Sbjct: 406 PHLASERVYTIMYSCWHEKADERPSFKILLS 436 >1U54-B nrPDB Length = 291 Score = 190 bits (482), Expect = 1e-48, Method: Composition-based stats. Identities = 65/294 (22%), Positives = 116/294 (39%), Gaps = 46/294 (15%) Query: 7 CRADQQYECVAEIGEGAYGKVFKARDLKNGGRFV--ALKRVRVQTGEEGMPLS-TIREVA 63 ++ + ++G+G++G V + G+ V A+K ++ + + IREV Sbjct: 14 LIGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVN 73 Query: 64 VLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPGVPTETI 122 + L +H N++RL+ V + +V E L L K + T+ Sbjct: 74 AMHSL---DHRNLIRLYGVVLT------PPMKMVTELAPLGSLLDRLRK-HQGHFLLGTL 123 Query: 123 KDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY----SFQMALTS 178 Q+ G+ +L S R +HRDL +N+L+ + +K+ DFGL R + Sbjct: 124 SRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEH 183 Query: 179 VVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKI-LDVIG 236 V + APE L +++ D W G EMF + + G + L KI + Sbjct: 184 RKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGER 243 Query: 237 LPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRIS 290 LP ED P+D+ +++++C P R + Sbjct: 244 LPRPEDCPQDI--------------------------YNVMVQCWAHKPEDRPT 271 >3I81-A nrPDB Length = 315 Score = 189 bits (481), Expect = 1e-48, Method: Composition-based stats. Identities = 63/308 (20%), Positives = 122/308 (39%), Gaps = 52/308 (16%) Query: 4 DGLCRADQQYECVAEIGEGAYGKVF----KARDLKNGGRFVALKRVRVQTGEEGMPLSTI 59 D A ++ E+G+G++G V+ K VA+K V + + + Sbjct: 11 DEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVN-EAASMRERIEFL 69 Query: 60 REVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVP----- 113 E +V++ F +VVRL V + + ++ E + DL +YL + Sbjct: 70 NEASVMKE---FNCHHVVRLLGVVSQGQ-----PTLVIMELMTRGDLKSYLRSLRPEMEN 121 Query: 114 EPGVPTETIKDMMF---QLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLAR-I 169 P + ++ M+ ++ G+ +L++++ VHRDL +N +V +K+ DFG+ R I Sbjct: 122 NPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDI 181 Query: 170 YSFQMALTSVVV--TLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVD 226 Y + + +PE L + T D+WS G + E+ + ++G S+ Sbjct: 182 YETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQ 241 Query: 227 QLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPA 286 L +++ L ++ P + +L+ C +NP Sbjct: 242 VLRFVMEGGLLDKPDNCPD--------------------------MLFELMRMCWQYNPK 275 Query: 287 KRISAYSA 294 R S Sbjct: 276 MRPSFLEI 283 >6E4F-A nrPDB Length = 290 Score = 189 bits (481), Expect = 1e-48, Method: Composition-based stats. Identities = 62/271 (22%), Positives = 118/271 (43%), Gaps = 20/271 (7%) Query: 5 GLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAV 64 + + E+G G +G V + G VA+K ++ + E I E V Sbjct: 25 SWEIDPKDLTFLKELGTGQFGVVKYGKWR--GQYDVAIKMIKEGSMSED---EFIEEAKV 79 Query: 65 LRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPGVPTETIK 123 + +L H +V+L+ VCT R + ++ E++ + L YL ++ T+ + Sbjct: 80 MMNLS---HEKLVQLYGVCTKQR-----PIFIITEYMANGCLLNYLREMRHR-FQTQQLL 130 Query: 124 DMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVT- 182 +M + +++L S + +HRDL +N LV G +K++DFGL+R Y TS V + Sbjct: 131 EMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSR-YVLDDEYTSSVGSK 189 Query: 183 --LWYRAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILDVIGLPG 239 + + PEVL+ S +++ D+W+ G + E++ K + ++ + I + L Sbjct: 190 FPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYR 249 Query: 240 EEDWPRDVALPRQAFHSKSAQPIEKFVTDID 270 V + + A F + Sbjct: 250 PHLASEKVYTIMYSCWHEKADERPTFKILLS 280 >5HLW-A nrPDB Length = 299 Score = 189 bits (480), Expect = 1e-48, Method: Composition-based stats. Identities = 63/265 (23%), Positives = 105/265 (39%), Gaps = 22/265 (8%) Query: 17 AEIGEGAYGKVFKARDLKNGGR--FVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHP 74 IG G +G V+ L N G+ A+K + + + G + E +++ F HP Sbjct: 26 EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLN-RITDIGEVSQFLTEGIIMK---DFSHP 81 Query: 75 NVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPGVPTETIKDMMFQLLRGL 133 NV+ L +C S E +V ++ DL ++ + + Q+ +G+ Sbjct: 82 NVLSLLGICLRS----EGSPLVVLPYMKHGDLRNFIRNETHNP-TVKDLIGFGLQVAKGM 136 Query: 134 DFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQ-----MALTSVVVTLWYRAP 188 +L S + VHRDL +N ++ +K+ADFGLAR + T + + + A Sbjct: 137 KYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMHDKEYYSVHNKTGAKLPVKWMAL 196 Query: 189 EVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDV 247 E L + T D+WS G + E+ P + + D +L L E P Sbjct: 197 ESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPD-- 254 Query: 248 ALPRQAFHSKSAQPIEKFVTDIDEL 272 P K P + EL Sbjct: 255 --PLYEVMLKCWHPKAEMRPSFSEL 277 >6FER-A nrPDB Length = 309 Score = 189 bits (480), Expect = 2e-48, Method: Composition-based stats. Identities = 66/307 (21%), Positives = 118/307 (38%), Gaps = 57/307 (18%) Query: 17 AEIGEGAYGKVFKA--------RDLK-------NGGRFVALKRVRVQTGEEGMPLSTIRE 61 ++GEG +G+V +D N VA+K +R + ++E Sbjct: 15 EKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLR-ADANKNARNDFLKE 73 Query: 62 VAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPGVPTE 120 + ++ L+ PN++ L VC + L ++ E+++ DL +L + P + Sbjct: 74 IKIMSRLKD---PNIIHLLAVCIT-----DDPLCMITEYMENGDLNQFLSRHEPPNSSSS 125 Query: 121 TIK--------DMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY-- 170 ++ M Q+ G+ +L S VHRDL +N LV + IK+ADFG++R Sbjct: 126 DVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYS 185 Query: 171 -SFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFR--RKPLFRGSSDVDQ 227 + V+ + + + E +L + T D+W+ G E F ++ + SD Sbjct: 186 GDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQV 245 Query: 228 LGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAK 287 + + D R LP+ A S L+L C + Sbjct: 246 IENTGEFFR-----DQGRQTYLPQPAICPDSVYK--------------LMLSCWRRDTKN 286 Query: 288 RISAYSA 294 R S Sbjct: 287 RPSFQEI 293 >1U59-A nrPDB Length = 287 Score = 188 bits (479), Expect = 2e-48, Method: Composition-based stats. Identities = 58/273 (21%), Positives = 111/273 (40%), Gaps = 22/273 (8%) Query: 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRF-VALKRVRVQTGEEGMPLSTI 59 +++D L AD E+G G +G V + + VA+K ++ Q E+ + Sbjct: 6 LKRDNLLIADI------ELGCGNFGSVRQGVYRMRKKQIDVAIKVLK-QGTEKADTEEMM 58 Query: 60 REVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPT 119 RE ++ L ++P +VRL VC L LV E +P Sbjct: 59 REAQIMHQL---DNPYIVRLIGVCQAEA------LMLVMEMAGGGPLHKFLVGKREEIPV 109 Query: 120 ETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY----SFQMA 175 + +++ Q+ G+ +L VHRDL +N+L+ + K++DFGL++ S+ A Sbjct: 110 SNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTA 169 Query: 176 LTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILDV 234 ++ L + APE + +++ D+WS G E + ++ + + I Sbjct: 170 RSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQG 229 Query: 235 IGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVT 267 + + P ++ + F+T Sbjct: 230 KRMECPPECPPELYALMSDCWIYKWEDRPDFLT 262 >2A1A-B nrPDB Length = 284 Score = 188 bits (479), Expect = 2e-48, Method: Composition-based stats. Identities = 72/301 (23%), Positives = 117/301 (38%), Gaps = 53/301 (17%) Query: 8 RADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRH 67 R ++ + IG G +G+VFKA+ +G +V +KRV+ + REV L Sbjct: 8 RFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYV-IKRVKYNNEK------AEREVKALAK 60 Query: 68 LETFEHPNVVRLFDVCTVSRTDRETK-----------LTLVFEHVD-QDLTTYLDKVPEP 115 L +H N+V D ET L + E D L +++K Sbjct: 61 L---DHVNIVHYNGCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGE 117 Query: 116 GVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMA 175 + ++ Q+ +G+D++HS ++++RDLKP NI + + Q+K+ DFGL Sbjct: 118 KLDKVLALELFEQITKGVDYIHSKKLINRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGK 177 Query: 176 LTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVI 235 T TL Y +PE + Y VDL+++G I AE+ Sbjct: 178 RTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELL---------------------- 215 Query: 236 GLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSAL 295 + + + F D+ K LL K L+ P R + L Sbjct: 216 -----HVCDTAFETSKFFTDLRDGIISDIF----DKKEKTLLQKLLSKKPEDRPNTSEIL 266 Query: 296 S 296 Sbjct: 267 R 267 >3C1X-A nrPDB Length = 373 Score = 188 bits (478), Expect = 3e-48, Method: Composition-based stats. Identities = 64/265 (24%), Positives = 105/265 (39%), Gaps = 22/265 (8%) Query: 17 AEIGEGAYGKVFKARDLKNGGR--FVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHP 74 IG G +G V+ L N G+ A+K + + + G + E +++ F HP Sbjct: 95 EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLN-RITDIGEVSQFLTEGIIMK---DFSHP 150 Query: 75 NVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPGVPTETIKDMMFQLLRGL 133 NV+ L +C S E +V ++ DL ++ + + Q+ +G+ Sbjct: 151 NVLSLLGICLRS----EGSPLVVLPYMKHGDLRNFIRNETHNP-TVKDLIGFGLQVAKGM 205 Query: 134 DFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLAR-----IYSFQMALTSVVVTLWYRAP 188 FL S + VHRDL +N ++ +K+ADFGLAR + T + + + A Sbjct: 206 KFLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEFDSVHNKTGAKLPVKWMAL 265 Query: 189 EVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDV 247 E L + T D+WS G + E+ P + + D +L L E P Sbjct: 266 ESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPD-- 323 Query: 248 ALPRQAFHSKSAQPIEKFVTDIDEL 272 P K P + EL Sbjct: 324 --PLYEVMLKCWHPKAEMRPSFSEL 346 >3SXS-A nrPDB Length = 268 Score = 188 bits (477), Expect = 3e-48, Method: Composition-based stats. Identities = 61/290 (21%), Positives = 114/290 (39%), Gaps = 44/290 (15%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLE 69 ++ + E+G G +G V + G VA+K ++ + E +E + L Sbjct: 7 REEITLLKELGSGQFGVVKLGKWK--GQYDVAVKMIKEGSMSED---EFFQEAQTMMKLS 61 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQL 129 HP +V+ + VC+ +E + +V E++ + G+ + +M + + Sbjct: 62 ---HPKLVKFYGVCS-----KEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDV 113 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVT---LWYR 186 G+ FL SH+ +HRDL +N LV +K++DFG+ R Y S V T + + Sbjct: 114 CEGMAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTR-YVLDDQYVSSVGTKFPVKWS 172 Query: 187 APEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILDVIGLPGEEDWPR 245 APEV Y++ D+W+ G + E+F K + ++ + + K+ L Sbjct: 173 APEVFHYFKYSSKSDVWAFGILMWEVFSLGKMPYDLYTNSEVVLKVSQGHRLYRPHL--- 229 Query: 246 DVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSAL 295 + ++ C P KR + L Sbjct: 230 -----------------------ASDTIYQIMYSCWHELPEKRPTFQQLL 256 >2OZO-A nrPDB Length = 613 Score = 187 bits (476), Expect = 5e-48, Method: Composition-based stats. Identities = 57/273 (20%), Positives = 111/273 (40%), Gaps = 22/273 (8%) Query: 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRF-VALKRVRVQTGEEGMPLSTI 59 +++D L AD E+G G +G V + + VA+K ++ Q E+ + Sbjct: 332 LKRDNLLIADI------ELGCGNFGSVRQGVYRMRKKQIDVAIKVLK-QGTEKADTEEMM 384 Query: 60 REVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPT 119 RE ++ L ++P +VRL VC L LV E +P Sbjct: 385 REAQIMHQL---DNPYIVRLIGVCQAEA------LMLVMEMAGGGPLHKFLVGKREEIPV 435 Query: 120 ETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY----SFQMA 175 + +++ Q+ G+ +L VHR+L +N+L+ + K++DFGL++ S+ A Sbjct: 436 SNVAELLHQVSMGMKYLEEKNFVHRNLAARNVLLVNRHYAKISDFGLSKALGADDSYYTA 495 Query: 176 LTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILDV 234 ++ L + APE + +++ D+WS G E + ++ + + I Sbjct: 496 RSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQG 555 Query: 235 IGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVT 267 + + P ++ + F+T Sbjct: 556 KRMECPPECPPELYALMSDCWIYKWEDRPDFLT 588 >5FM2-A nrPDB Length = 355 Score = 187 bits (474), Expect = 7e-48, Method: Composition-based stats. Identities = 62/314 (19%), Positives = 120/314 (38%), Gaps = 45/314 (14%) Query: 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGR----FVALKRVRVQTGEEGMPL 56 +E + +GEG +GKV KA GR VA+K ++ + Sbjct: 54 LEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLK-ENASPSELR 112 Query: 57 STIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVP-- 113 + E VL+ HP+V++L+ C+ ++ L L+ E+ L +L + Sbjct: 113 DLLSEFNVLKQ---VNHPHVIKLYGACS-----QDGPLLLIVEYAKYGSLRGFLRESRKV 164 Query: 114 --------------------EPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILV 153 E + + +Q+ +G+ +L ++VHRDL +NILV Sbjct: 165 GPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILV 224 Query: 154 TSSGQIKLADFGLARIY---SFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFA 210 ++K++DFGL+R + + + + + A E L Y T D+WS G + Sbjct: 225 AEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLW 284 Query: 211 EMFR-RKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDI 269 E+ + G ++ +++ + P + + + + Sbjct: 285 EIVTLGGNPYPGIPP----ERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVF 340 Query: 270 DELGKDLLLKCLTF 283 ++ KDL K + Sbjct: 341 ADISKDL-EKMMVK 353 >3PP0-A nrPDB Length = 338 Score = 187 bits (474), Expect = 8e-48, Method: Composition-based stats. Identities = 63/286 (22%), Positives = 112/286 (39%), Gaps = 22/286 (7%) Query: 2 EKDGLCRADQQYEC--VAEIGEGAYGKVFKARDLKNGGRF---VALKRVRVQTGEEGMPL 56 L R ++ E V +G GA+G V+K + +G VA+K +R T + Sbjct: 6 PNQALLRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANK- 64 Query: 57 STIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPG 116 + E V+ P V RL +C S + LV + + + Sbjct: 65 EILDEAYVM---AGVGSPYVSRLLGICLTST------VQLVTQLMPYGCLLDHVRENRGR 115 Query: 117 VPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQ--- 173 + ++ + + Q+ +G+ +L R+VHRDL +N+LV S +K+ DFGLAR+ Sbjct: 116 LGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETE 175 Query: 174 MALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKIL 232 V + + A E +L+ + D+WS G E+ + G + + Sbjct: 176 YHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLE 235 Query: 233 DVIGLPGEEDWPRDVALPR---QAFHSKSAQPIEKFVTDIDELGKD 275 LP DV + S+ + V++ + +D Sbjct: 236 KGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARD 281 >5HVK-A nrPDB Length = 315 Score = 186 bits (473), Expect = 9e-48, Method: Composition-based stats. Identities = 74/324 (22%), Positives = 130/324 (40%), Gaps = 55/324 (16%) Query: 16 VAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPN 75 +G+G +G+ K + G V + +R +E + ++EV V+R L EHPN Sbjct: 19 GEVLGKGCFGQAIKVTHRETGEVMVMKELIRF---DEETQRTFLKEVKVMRCL---EHPN 72 Query: 76 VVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDF 135 V++ V ++ +L + E++ + K + P + G+ + Sbjct: 73 VLKFIGVLY-----KDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAY 127 Query: 136 LHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY---------------SFQMALTSVV 180 LHS ++HR+L N LV + + +ADFGLAR+ + +VV Sbjct: 128 LHSMNIIHRNLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVV 187 Query: 181 VTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGE 240 ++ APE++ SY VD++S G + E+ R ++D D L P Sbjct: 188 GNPYWMAPEMINGRSYDEKVDVFSFGIVLCEIIGRV-----NADPDYL---------PRT 233 Query: 241 EDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 D+ +V + + P +T +C +P KR S L H + Sbjct: 234 MDFGLNVRGFLDRYCPPNCPPSFFPITV----------RCCDLDPEKRPSFVK-LEH-WL 281 Query: 301 QDLERCKENLDSHLPPSQNTSELN 324 + L +L HLP +L+ Sbjct: 282 ETLRM---HLAGHLPLGPQLEQLD 302 >3M42-A nrPDB Length = 299 Score = 186 bits (473), Expect = 1e-47, Method: Composition-based stats. Identities = 63/307 (20%), Positives = 114/307 (37%), Gaps = 56/307 (18%) Query: 11 QQYECV-AEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLE 69 Y+ +G G GKV + + + +F ALK + REV + H Sbjct: 17 DDYKVTSQVLGLGINGKVLQIFNKRTQEKF-ALKML-------QDCPKARREVEL--HWR 66 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQD-LTTYLDKVPEPGVPTETIKDMMFQ 128 + P++VR+ DV R+ L +V E +D L + + + ++M Sbjct: 67 ASQCPHIVRIVDVYENLYAGRKC-LLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKS 125 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTS---SGQIKLADFGLARIYSFQMALTSVVVTLWY 185 + + +LHS + HRD+KP+N+L TS + +KL DFG A+ + Sbjct: 126 IGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT-------------- 171 Query: 186 RAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPR 245 Y D+WS+G I + P F + GL Sbjct: 172 -------GEKYDKSCDMWSLGVIMYILLCGYPPFYSNH------------GLAISPGMKT 212 Query: 246 DVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLER 305 + + + F + +++ E K L+ L P +R++ ++HP+ + Sbjct: 213 RIRMGQYEFPNPE-------WSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTK 265 Query: 306 CKENLDS 312 + Sbjct: 266 VPQTPLH 272 >2WTK-B nrPDB Length = 373 Score = 186 bits (473), Expect = 1e-47, Method: Composition-based stats. Identities = 74/335 (22%), Positives = 123/335 (36%), Gaps = 43/335 (12%) Query: 13 YECVAEIGEGAY---GKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLE 69 YE + IG+G + V AR K G +V ++R+ ++ M E L + Sbjct: 11 YELLTVIGKG-FEDLMTVNLAR-YKPTGEYVTVRRINLEACSNEMVTFLQGE---LHVSK 65 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPGVPTETIKDMMFQ 128 F HPN+V + +L +V + + G+ I ++ Sbjct: 66 LFNHPNIVPYRATFIA-----DNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQG 120 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADF--GLARIYSFQMAL------TSVV 180 +L+ LD++H VHR +K +IL++ G++ L+ L+ I Q V Sbjct: 121 VLKALDYIHHMGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSV 180 Query: 181 VTLWYRAPEVLLQ--SSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGK-------- 230 L + +PEVL Q Y D++SVG E+ F+ L + Sbjct: 181 KVLPWLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPC 240 Query: 231 ILDVIGLPGEE-----------DWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLK 279 +LD +P EE D S P + + + Sbjct: 241 LLDTSTIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTFSPHFHHFVEQ 300 Query: 280 CLTFNPAKRISAYSALSHPYFQDLERCKENLDSHL 314 CL NP R SA + L+H +F+ ++R L Sbjct: 301 CLQRNPDARPSASTLLNHSFFKQIKRRASEALPEL 335 >4LRM-A nrPDB Length = 334 Score = 185 bits (471), Expect = 2e-47, Method: Composition-based stats. Identities = 55/276 (19%), Positives = 116/276 (42%), Gaps = 17/276 (6%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRF---VALKRVRVQTGEEGMPLSTIREVAVLR 66 + +++ + +G GA+G V+K + G + VA+K +R T + + E V+ Sbjct: 18 ETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANK-EILDEAYVMA 76 Query: 67 HLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMM 126 ++ +P+V RL +C S + L+ + + + + + ++ + + Sbjct: 77 SVDNPGNPHVCRLLGICLTST------VQLITQLMPFGCLLDYVREHKDNIGSQYLLNWC 130 Query: 127 FQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVV---TL 183 Q+ +G+++L R+VHRDL +N+LV + +K+ DFGLA++ + + Sbjct: 131 VQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPI 190 Query: 184 WYRAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILDVIGLPGEED 242 + A E +L Y D+WS G E+ + G + + LP Sbjct: 191 KWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPI 250 Query: 243 WPRDVALPR---QAFHSKSAQPIEKFVTDIDELGKD 275 DV + + S + + + ++ +D Sbjct: 251 CTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARD 286 >3UIU-A nrPDB Length = 306 Score = 184 bits (468), Expect = 3e-47, Method: Composition-based stats. Identities = 72/314 (22%), Positives = 117/314 (37%), Gaps = 66/314 (21%) Query: 8 RADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRH 67 R ++ + IG G +G+VFKA+ +G +V ++RV+ + REV L Sbjct: 9 RFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYV-IRRVKYNNEK------AEREVKALAK 61 Query: 68 LETFEHPNVVRLFDVCTVSRTDRETK------------------------LTLVFEHVD- 102 L +H N+V D ET L + E D Sbjct: 62 L---DHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDK 118 Query: 103 QDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLA 162 L +++K + ++ Q+ +G+D++HS +++HRDLKP NI + + Q+K+ Sbjct: 119 GTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIG 178 Query: 163 DFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGS 222 DFGL T TL Y +PE + Y VDL+++G I AE+ Sbjct: 179 DFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELL--------- 229 Query: 223 SDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLT 282 + + + F D+ K LL K L+ Sbjct: 230 ------------------HVCDTAFETSKFFTDLRDGIISDIF----DKKEKTLLQKLLS 267 Query: 283 FNPAKRISAYSALS 296 P R + L Sbjct: 268 KKPEDRPNTSEILR 281 >6CTH-A nrPDB Length = 309 Score = 184 bits (467), Expect = 4e-47, Method: Composition-based stats. Identities = 57/217 (26%), Positives = 101/217 (46%), Gaps = 18/217 (8%) Query: 6 LCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVL 65 L + + ++GEG +G V++ L++ ++A+K+V + EV ++ Sbjct: 10 LAKVTSNFNAENKLGEGGFGSVYRGF-LRDSDTYIAVKKVSR--ASKQGIKEYASEVKII 66 Query: 66 RHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPGVPTETIKD 124 L H N+V+L C +L LV+E + + L +++ K + + E Sbjct: 67 SRLR---HKNLVKLIGWC-----HERGELMLVYEFMANGSLDSHIFK-GKSLLTWEVRYR 117 Query: 125 MMFQLLRGLDFLHSHR---VVHRDLKPQNILVTSSGQIKLADFGLARIYSF--QMALTSV 179 ++ L L +LH V+HRD+K NI++ SS KL DFGLAR+ + T + Sbjct: 118 IVKDLASALLYLHEEGDHCVLHRDIKTSNIMLDSSFNAKLGDFGLARLVDHAKGLKKTLL 177 Query: 180 VVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRK 216 T+ Y APE L + D++S G + E+ + Sbjct: 178 AGTVGYMAPECLSSGKASKESDVYSFGVVALEIASGR 214 >5GNK-A nrPDB Length = 297 Score = 183 bits (465), Expect = 9e-47, Method: Composition-based stats. Identities = 55/276 (19%), Positives = 116/276 (42%), Gaps = 20/276 (7%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRF---VALKRVRVQTGEEGMPLSTIREVAVLR 66 + +++ + +G GA+G V+K + G + VA+K +R T + + E V+ Sbjct: 18 ETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANK-EILDEAYVM- 75 Query: 67 HLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMM 126 + ++P+V RL +C S + L+ + + + + + ++ + + Sbjct: 76 --ASVDNPHVCRLLGICLTST------VQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWC 127 Query: 127 FQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVV---TL 183 Q+ +G+++L R+VHRDL +N+LV + +K+ DFGLA++ + + Sbjct: 128 VQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPI 187 Query: 184 WYRAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILDVIGLPGEED 242 + A E +L Y D+WS G E+ + G + + LP Sbjct: 188 KWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPI 247 Query: 243 WPRDVALPR---QAFHSKSAQPIEKFVTDIDELGKD 275 DV + + S + + + ++ +D Sbjct: 248 CTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARD 283 >3DLS-A nrPDB Length = 335 Score = 182 bits (463), Expect = 1e-46, Method: Composition-based stats. Identities = 62/313 (19%), Positives = 120/313 (38%), Gaps = 53/313 (16%) Query: 1 MEKDGLC----RADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPL 56 +E +GL Q+Y ++ +G GA+G V+ A D + V +K ++ + E + Sbjct: 10 VELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKEKNKEVV-VKFIKKEKVLEDCWI 68 Query: 57 STIR------EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLD 110 + E+A+L EH N++++ D+ + + LV E L + Sbjct: 69 EDPKLGKVTLEIAILSR---VEHANIIKVLDIF-----ENQGFFQLVMEKHGSGLDLFAF 120 Query: 111 KVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY 170 P + + QL+ + +L ++HRD+K +NI++ IKL DFG A Sbjct: 121 IDRHPRLDEPLASYIFRQLVSAVGYLRLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYL 180 Query: 171 SFQMALTSVVVTLWYRAPEVLLQSSY-ATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLG 229 + T+ Y APEVL+ + Y +++WS+G + + F +L Sbjct: 181 ERGKLFYTFCGTIEYCAPEVLMGNPYRGPELEMWSLGVTLYTLVFEENPFC------ELE 234 Query: 230 KILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRI 289 + ++ P + + L+ L P +R Sbjct: 235 ETVEAAIHPPYL---------------------------VSKELMSLVSGLLQPVPERRT 267 Query: 290 SAYSALSHPYFQD 302 + ++ P+ Sbjct: 268 TLEKLVTDPWVTQ 280 >3LZB-A nrPDB Length = 327 Score = 182 bits (463), Expect = 2e-46, Method: Composition-based stats. Identities = 56/292 (19%), Positives = 113/292 (38%), Gaps = 43/292 (14%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRF---VALKRVRVQTGEEGMPLSTIREVAVLR 66 + +++ + +G GA+G V+K + G + VA+K +R T + + E V+ Sbjct: 14 ETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANK-EILDEAYVM- 71 Query: 67 HLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMM 126 + ++P+V RL +C S + L+ + + + + + ++ + + Sbjct: 72 --ASVDNPHVCRLLGICLTST------VQLITQLMPFGCLLDYVREHKDNIGSQYLLNWC 123 Query: 127 FQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVV---TL 183 Q+ +G+++L R+VHRDL +N+LV + +K+ DFGLA++ + + Sbjct: 124 VQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPI 183 Query: 184 WYRAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILDVIGLPGEED 242 + A E +L Y D+WS G E+ + G + + LP Sbjct: 184 KWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPI 243 Query: 243 WPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSA 294 DV + ++ KC + R Sbjct: 244 CTIDVYM--------------------------IMRKCWMIDADSRPKFREL 269 >3ZZW-A nrPDB Length = 289 Score = 182 bits (462), Expect = 2e-46, Method: Composition-based stats. Identities = 70/287 (24%), Positives = 127/287 (44%), Gaps = 40/287 (13%) Query: 17 AEIGEGAYGKVFKARDLKN----GGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 E+GE +GKV+K + VA+K ++ + EG R A+LR + Sbjct: 15 EELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKA--EGPLREEFRHEAMLR--ARLQ 70 Query: 73 HPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYL--------------DKVPEPGV 117 HPNVV L V T ++ L+++F + DL +L D+ + + Sbjct: 71 HPNVVCLLGVVT-----KDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSAL 125 Query: 118 PTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY---SFQM 174 ++ Q+ G+++L SH VVH+DL +N+LV +K++D GL R + Sbjct: 126 EPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYK 185 Query: 175 ALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILD 233 L + ++ + + APE ++ ++ D+WS G + E+F + G S+ D + I + Sbjct: 186 LLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRN 245 Query: 234 VIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKC 280 LP +D P V ++ + +F + KD+ + Sbjct: 246 RQVLPCPDDCPAWV-------YALMIECWNEFPSR-RPRFKDIHSRL 284 >4M7I-A nrPDB Length = 299 Score = 182 bits (461), Expect = 3e-46, Method: Composition-based stats. Identities = 68/292 (23%), Positives = 120/292 (41%), Gaps = 30/292 (10%) Query: 8 RADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRH 67 R +E + +G G +G VF+A++ + A+KR+R+ E +REV L Sbjct: 2 RYLTDFEPIQCLGRGGFGVVFEAKNKVDDCN-YAIKRIRLPN-RELAREKVMREVKALAK 59 Query: 68 LETFEHPNVVRLFDVCTVSRTDRE-------TKLTLVFEHVDQD-LTTYLDKVPEPGVPT 119 L EHP +VR F+ T + L + + ++ L +++ Sbjct: 60 L---EHPGIVRYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERE 116 Query: 120 ETI-KDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQM---- 174 ++ + Q+ ++FLHS ++HRDLKP NI T +K+ DFGL Sbjct: 117 RSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQT 176 Query: 175 ---------ALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDV 225 T V T Y +PE + +SY+ VD++S+G I E+ P V Sbjct: 177 VLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELL--YPFSTQMERV 234 Query: 226 DQLGKILDVIGLPGE-EDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDL 276 L + ++ P + +P + + + + E + + +DL Sbjct: 235 RTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDL 286 >5VD3-A nrPDB Length = 311 Score = 182 bits (461), Expect = 3e-46, Method: Composition-based stats. Identities = 74/294 (25%), Positives = 110/294 (37%), Gaps = 38/294 (12%) Query: 9 ADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHL 68 Q ++ ++ +G G+YG+VFK R K GR A+KR + EV H Sbjct: 55 FQQSFQRLSRLGHGSYGEVFKVR-SKEDGRLYAVKRSMSPFRGPKDRARKLAEVG--SHE 111 Query: 69 ETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQ 128 + +HP VRL + L L E L + + +P + + Sbjct: 112 KVGQHPCCVRL-----EQAWEEGGILYLQTELCGPSLQQHCE-AWGASLPEAQVWGYLRD 165 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAP 188 L L LHS +VH D+KP NI + G+ KL DFGL A Y AP Sbjct: 166 TLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAP 225 Query: 189 EVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA 248 E LLQ SY T D++S+G E+ L G QL + Sbjct: 226 E-LLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQ------------------ 266 Query: 249 LPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQD 302 +F + + +L+ L +P R +A + L+ P + Sbjct: 267 ----------GYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQ 310 >4FL3-A nrPDB Length = 635 Score = 181 bits (460), Expect = 3e-46, Method: Composition-based stats. Identities = 60/280 (21%), Positives = 113/280 (40%), Gaps = 44/280 (15%) Query: 17 AEIGEGAYGKVFKAR-DLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPN 75 E+G G +G V K +K + VA+K ++ + + + + E V++ L ++P Sbjct: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQL---DNPY 431 Query: 76 VVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPGVPTETIKDMMFQLLRGLD 134 +VR+ +C LV E + L YL + V + I +++ Q+ G+ Sbjct: 432 IVRMIGICEAES------WMLVMEMAELGPLNKYLQQNRH--VKDKNIIELVHQVSMGMK 483 Query: 135 FLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY----SFQMALTSVVVTLWYRAPEV 190 +L VHRDL +N+L+ + K++DFGL++ ++ A T + + APE Sbjct: 484 YLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPEC 543 Query: 191 LLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVAL 249 + +++ D+WS G + E F + +RG + + + PR Sbjct: 544 INYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPR---- 599 Query: 250 PRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRI 289 DL+ C T++ R Sbjct: 600 ----------------------EMYDLMNLCWTYDVENRP 617 >5TOS-A nrPDB Length = 395 Score = 181 bits (460), Expect = 3e-46, Method: Composition-based stats. Identities = 75/334 (22%), Positives = 138/334 (41%), Gaps = 44/334 (13%) Query: 9 ADQQYECVAEIGEGAYGKVFKARDLKNG--------GRFVALKRVRVQTGEEGMPLSTIR 60 A + + + IGEG +G VFK ++ G +A+K++ + + + Sbjct: 63 ATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQ--GHREWLT 120 Query: 61 EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPE--PGV 117 E+ L L HPN+V+L C + LV+E + L +L + + Sbjct: 121 EINYLGQLS---HPNLVKLIGYCL-----EDEHRLLVYEFMQKGSLENHLFRRGAYFKPL 172 Query: 118 PTETIKDMMFQLLRGLDFLHSH--RVVHRDLKPQNILVTSSGQIKLADFGLAR---IYSF 172 P ++ +GL FLHS +V++RD+K NIL+ + KL+DFGLAR + Sbjct: 173 PWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDL 232 Query: 173 QMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKIL 232 T V+ T Y APE + D++S G + E+ K + + + Sbjct: 233 SYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLV- 291 Query: 233 DVIGLPGEEDWPRDVALPRQAFHSKSAQPIE-KFVTDIDELGKDLLLKCLTFNPAKRISA 291 DW R ++ ++ +++ + + ++CL+F P R + Sbjct: 292 ---------DWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTM 342 Query: 292 YSALSHPYFQDLERCKENL--DSHLPPSQNTSEL 323 + L++ ++NL S P ++T +L Sbjct: 343 DQV-----VRALQQLQDNLGKPSQTNPVKDTKKL 371 >4C59-A nrPDB Length = 340 Score = 180 bits (456), Expect = 9e-46, Method: Composition-based stats. Identities = 68/305 (22%), Positives = 124/305 (40%), Gaps = 56/305 (18%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETF 71 + + EG + V++A+D+ GR ALKR+ E+ + I+EV ++ L Sbjct: 28 RLRVRRVLAEGGFAFVYEAQDV-GSGREYALKRLLSNEEEKN--RAIIQEVCFMKKLSG- 83 Query: 72 EHPNVVRLFDVCTVSRTDRET---KLTLVFEHVDQDLTTYLDKVPEPG-VPTETIKDMMF 127 HPN+V+ ++ + + +T + L+ E L +L K+ G + +T+ + + Sbjct: 84 -HPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGPLSCDTVLKIFY 142 Query: 128 QLLRGLDFLHSHR--VVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALT-------- 177 Q R + +H + ++HRDLK +N+L+++ G IKL DFG A S + Sbjct: 143 QTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRAL 202 Query: 178 -----SVVVTLWYRAPEVL---LQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLG 229 + T YR PE++ D+W++GCI + R+ F + + Sbjct: 203 VEEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDGAKL---- 258 Query: 230 KILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRI 289 +I++ D V L+ L NP +R+ Sbjct: 259 RIVNGKYSIPPHDTQYTV-------------------------FHSLIRAMLQVNPEERL 293 Query: 290 SAYSA 294 S Sbjct: 294 SIAEV 298 >3PLS-A nrPDB Length = 298 Score = 180 bits (456), Expect = 1e-45, Method: Composition-based stats. Identities = 60/284 (21%), Positives = 106/284 (37%), Gaps = 42/284 (14%) Query: 17 AEIGEGAYGKVFKA--RDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHP 74 IG+G +G V+ D A+K + T + + + +RE ++R HP Sbjct: 27 RVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQV-EAFLREGLLMR---GLNHP 82 Query: 75 NVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLD 134 NV+ L + L+ DL ++ + P+ + + Q+ RG++ Sbjct: 83 NVLALIGIMLPP---EGLPHVLLPYMCHGDLLQFI-RSPQRNPTVKDLISFGLQVARGME 138 Query: 135 FLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQ-----MALTSVVVTLWYRAPE 189 +L + VHRDL +N ++ S +K+ADFGLAR + + + + A E Sbjct: 139 YLAEQKFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWTALE 198 Query: 190 VLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA 248 L + T D+WS G + E+ P +R D + LP E P + Sbjct: 199 SLQTYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSLY 258 Query: 249 LPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAY 292 ++ +C +PA R + Sbjct: 259 Q--------------------------VMQQCWEADPAVRPTFR 276 >3Q4U-A nrPDB Length = 301 Score = 180 bits (456), Expect = 1e-45, Method: Composition-based stats. Identities = 76/311 (24%), Positives = 124/311 (39%), Gaps = 60/311 (19%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETF 71 + +G+G YG+V++ G VA+K + + + + +LR Sbjct: 9 DITLLECVGKGRYGEVWRG---SWQGENVAVKIFSSRDEKSWFRETELYNTVMLR----- 60 Query: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPGVPTETIKDMMFQLL 130 H N++ SR T+L L+ + + L YL + T + ++ + Sbjct: 61 -HENILGFIASDMTSR-HSSTQLWLITHYHEMGSLYDYLQLTT---LDTVSCLRIVLSIA 115 Query: 131 RGLDFLH--------SHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMAL-----T 177 GL LH + HRDLK +NILV +GQ +AD GLA ++S Sbjct: 116 SGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNN 175 Query: 178 SVVVTLWYRAPEVLLQ-------SSYATPVDLWSVGCIFAEMFRR----------KPLFR 220 V T Y APEVL + SY VD+W+ G + E+ RR KP F Sbjct: 176 PRVGTKRYMAPEVLDETIQVDCFDSY-KRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFY 234 Query: 221 GSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKC 280 D P ED + V + +Q + + + +T + + L+ +C Sbjct: 235 DVVPND-----------PSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAK----LMKEC 279 Query: 281 LTFNPAKRISA 291 NP+ R++A Sbjct: 280 WYQNPSARLTA 290 >4PL5-B nrPDB Length = 435 Score = 179 bits (455), Expect = 1e-45, Method: Composition-based stats. Identities = 87/302 (28%), Positives = 131/302 (43%), Gaps = 54/302 (17%) Query: 18 EIGEGAYGK-VFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNV 76 +G GA G V+K R VA+KR+ + REV +LR + EHPNV Sbjct: 34 VLGHGAEGTIVYKGMF---DNRDVAVKRILPECFS-----FADREVQLLRE--SDEHPNV 83 Query: 77 VRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFL 136 +R F CT + + E L Y+++ + E I ++ Q GL L Sbjct: 84 IRYF--CTEKDRQFQ---YIAIELCAATLQEYVEQKDFAHLGLEPI-TLLHQTTSGLAHL 137 Query: 137 HSHRVVHRDLKPQNILV---TSSGQIK--LADFGLARIYSFQMA----LTSVVVTLWYRA 187 HS +VHRDLKP NIL+ + G+IK ++DFGL + + + V T + A Sbjct: 138 HSLNIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIA 197 Query: 188 PEVLLQS---SYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILDVIGLPGEEDW 243 PE+L + + VD++S GC+F + F G S Q +L L Sbjct: 198 PEMLSEDCKDNPTYTVDIFSAGCVFYYVISEGYHPF-GKSLQRQANILLGACNL------ 250 Query: 244 PRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDL 303 FHS + D + ++L+ K + +P +R SA L HP+F L Sbjct: 251 --------DCFHSDKHE---------DVIARELIEKMIAMDPQQRPSAKHVLKHPFFWSL 293 Query: 304 ER 305 E+ Sbjct: 294 EK 295 >4OW8-A nrPDB Length = 283 Score = 178 bits (453), Expect = 2e-45, Method: Composition-based stats. Identities = 71/280 (25%), Positives = 112/280 (40%), Gaps = 34/280 (12%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETF 71 +Y I G G+V++A D + G R VA+K ++ + + P R A R Sbjct: 12 RYRLQRLIATGGMGQVWEAVDNRLGRR-VAVKVLKSEFSSD--PEFIERFRAEARTTAML 68 Query: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQD-LTTYLDKVPEPGVPTETIKDMMFQLL 130 HP + + D LV E V+ + L + L + + DM+ Q Sbjct: 69 NHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGR--LSLRHALDMLEQTG 126 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTS--VVVTLWYRAP 188 R L H+ +VHRD+KP NIL+T +GQ+K+ DFG+A+ + V+ T Y AP Sbjct: 127 RALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAP 186 Query: 189 EVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA 248 E L + D++S+G + E K F G + K + Sbjct: 187 EQALGHDASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIK--------------- 231 Query: 249 LPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKR 288 +P D+ ++L+ L NPA R Sbjct: 232 -----------EPPPPLPPDLPPNVRELIEITLVKNPAMR 260 >4X3F-A nrPDB Length = 337 Score = 178 bits (453), Expect = 2e-45, Method: Composition-based stats. Identities = 71/280 (25%), Positives = 112/280 (40%), Gaps = 34/280 (12%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETF 71 +Y I G G+V++A D + G R VA+K ++ + + P R A R Sbjct: 13 RYRLQRLIATGGMGQVWEAVDNRLGRR-VAVKVLKSEFSSD--PEFIERFRAEARTTAML 69 Query: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQD-LTTYLDKVPEPGVPTETIKDMMFQLL 130 HP + + D LV E V+ + L + L + + DM+ Q Sbjct: 70 NHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGR--LSLRHALDMLEQTG 127 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTS--VVVTLWYRAP 188 R L H+ +VHRD+KP NIL+T +GQ+K+ DFG+A+ + V+ T Y AP Sbjct: 128 RALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAP 187 Query: 189 EVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA 248 E L + D++S+G + E K F G + K + Sbjct: 188 EQALGHDASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIK--------------- 232 Query: 249 LPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKR 288 +P D+ ++L+ L NPA R Sbjct: 233 -----------EPPPPLPPDLPPNVRELIEITLVKNPAMR 261 >6B2Q-A nrPDB Length = 317 Score = 178 bits (453), Expect = 2e-45, Method: Composition-based stats. Identities = 71/280 (25%), Positives = 112/280 (40%), Gaps = 34/280 (12%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETF 71 +Y I G G+V++A D + G R VA+K ++ + + P R A R Sbjct: 33 RYRLQRLIATGGMGQVWEAVDNRLGRR-VAVKVLKSEFSSD--PEFIERFRAEARTTAML 89 Query: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQD-LTTYLDKVPEPGVPTETIKDMMFQLL 130 HP + + D LV E V+ + L + L + + DM+ Q Sbjct: 90 NHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGR--LSLRHALDMLEQTG 147 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTS--VVVTLWYRAP 188 R L H+ +VHRD+KP NIL+T +GQ+K+ DFG+A+ + V+ T Y AP Sbjct: 148 RALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAP 207 Query: 189 EVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA 248 E L + D++S+G + E K F G + K + Sbjct: 208 EQALGHDASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIK--------------- 252 Query: 249 LPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKR 288 +P D+ ++L+ L NPA R Sbjct: 253 -----------EPPPPLPPDLPPNVRELIEITLVKNPAMR 281 >5O0Y-A nrPDB Length = 579 Score = 178 bits (453), Expect = 2e-45, Method: Composition-based stats. Identities = 72/300 (24%), Positives = 125/300 (41%), Gaps = 54/300 (18%) Query: 24 YGKVFKARDLKNGGRFVALKRVRVQT-----GEEGMPLSTIREVAVLRHLETFEHPNVVR 78 + +V+KA DL R+VA+K ++ +E RE + + L +HP +V+ Sbjct: 297 FSEVYKAFDL-TEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKEL---DHPRIVK 352 Query: 79 LFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLH 137 L+D ++ V E+ + DL YL + + + + ++ Q++ L +L+ Sbjct: 353 LYDYFSLDT----DSFCTVLEYCEGNDLDFYLKQ--HKLMSEKEARSIIMQIVNALKYLN 406 Query: 138 SHR--VVHRDLKPQNILVTSS---GQIKLADFGLARIYSF-------QMALTSV-VVTLW 184 + ++H DLKP NIL+ + G+IK+ DFGL++I M LTS T W Sbjct: 407 EIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYW 466 Query: 185 YRAPEVLLQSS----YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGE 240 Y PE + + VD+WSVG IF + + F G + Q Sbjct: 467 YLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPF-GHNQSQQ------------- 512 Query: 241 EDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 D ++ + + +P+ + K + +CL + RI PY Sbjct: 513 -DILQENTILKATEVQFPPKPV------VTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 565 >4X7Q-B nrPDB Length = 312 Score = 178 bits (451), Expect = 3e-45, Method: Composition-based stats. Identities = 71/302 (23%), Positives = 106/302 (35%), Gaps = 51/302 (16%) Query: 9 ADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR----EVAV 64 + +Y +G+G +G VF A VA+K + PLS EVA+ Sbjct: 29 FEAEYRLGPLLGKGGFGTVF-AGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVAL 87 Query: 65 LRHLE-TFEHPNVVRLFDVCTVSRTDRETKLTLVFE--HVDQDLTTYLDKVPEPGVPTET 121 L + HP V+RL D LV E QDL Y+ + + Sbjct: 88 LWKVGAGGGHPGVIRLLDWFETQEG-----FMLVLERPLPAQDLFDYI--TEKGPLGEGP 140 Query: 122 IKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVT-SSGQIKLADFGLARIYSFQMALTSVV 180 + Q++ + HS VVHRD+K +NIL+ G KL DFG + T Sbjct: 141 SRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLH-DEPYTDFD 199 Query: 181 VTLWYRAPEVLLQSSY-ATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPG 239 T Y PE + + Y A P +WS+G + +M F ++ Sbjct: 200 GTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEI-------------- 245 Query: 240 EEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPY 299 + F + L+ +CL P+ R S L P+ Sbjct: 246 -------------------LEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPW 286 Query: 300 FQ 301 Q Sbjct: 287 MQ 288 >4Y83-A nrPDB Length = 332 Score = 178 bits (451), Expect = 3e-45, Method: Composition-based stats. Identities = 73/281 (25%), Positives = 115/281 (40%), Gaps = 41/281 (14%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVR 78 I GA+GKV+ A+D+K R A K + V + E+ F H N+ Sbjct: 81 IPRGAFGKVYLAQDIKTKKRM-ACKLIPVDQFKPSDV-----EIQAC-----FRHENIAE 129 Query: 79 LFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPG-VPTETIKDMMFQLLRGLDFLH 137 L+ T + L E + + L+K+ G + I + +L+GLDFLH Sbjct: 130 LYGAVLWGET-----VHLFMEAGEGG--SVLEKLESCGPMREFEIIWVTKHVLKGLDFLH 182 Query: 138 SHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMAL-TSVVVTLWYRAPEVLLQSSY 196 S +V+H D+KP NI+ S+ + L DFGL+ + + + T Y +PEV+L + Sbjct: 183 SKKVIHHDIKPSNIVFMSTKAV-LVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILCRGH 241 Query: 197 ATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHS 256 +T D++S+G M P + + +PR Sbjct: 242 STKADIYSLGATLIHMQTGTPPW--------------------VKRYPRSAYPSYLYIIH 281 Query: 257 KSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSH 297 K A P+E D ++L+ L NP R A L H Sbjct: 282 KQAPPLEDIADDCSPGMRELIEASLERNPNHRPRAADLLKH 322 >5C26-A nrPDB Length = 299 Score = 177 bits (450), Expect = 4e-45, Method: Composition-based stats. Identities = 60/280 (21%), Positives = 113/280 (40%), Gaps = 44/280 (15%) Query: 17 AEIGEGAYGKVFKAR-DLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPN 75 E+G G +G V K +K + VA+K ++ + + + + E V++ L ++P Sbjct: 33 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQL---DNPY 89 Query: 76 VVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPGVPTETIKDMMFQLLRGLD 134 +VR+ +C LV E + L YL + V + I +++ Q+ G+ Sbjct: 90 IVRMIGICEAES------WMLVMEMAELGPLNKYLQQNRH--VKDKNIIELVHQVSMGMK 141 Query: 135 FLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY----SFQMALTSVVVTLWYRAPEV 190 +L VHRDL +N+L+ + K++DFGL++ ++ A T + + APE Sbjct: 142 YLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPEC 201 Query: 191 LLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVAL 249 + +++ D+WS G + E F + +RG + + + PR Sbjct: 202 INYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPR---- 257 Query: 250 PRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRI 289 DL+ C T++ R Sbjct: 258 ----------------------EMYDLMNLCWTYDVENRP 275 >2PMN-X nrPDB Length = 348 Score = 177 bits (448), Expect = 9e-45, Method: Composition-based stats. Identities = 69/310 (22%), Positives = 126/310 (40%), Gaps = 30/310 (9%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 Y + + +G + K+ + +F ALK+ E+ + + + Sbjct: 31 NDYRIIRTLNQGKFNKIILC---EKDNKFYALKKYEKSLLEKKRDFTKSNNDKISIKSKY 87 Query: 71 FEHPNVVRLF-----DVCTVSRT--DRETKLTLVFEHVDQDL-------TTYLDKVPEPG 116 + N +++ + C ++ +++E+++ D LDK Sbjct: 88 DDFKNELQIITDIKNEYCLTCEGIITNYDEVYIIYEYMENDSILKFDEYFFVLDKNYTCF 147 Query: 117 VPTETIKDMMFQLLRGLDFLH-SHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMA 175 +P + IK ++ +L ++H + HRD+KP NIL+ +G++KL+DFG + Y Sbjct: 148 IPIQVIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMDKNGRVKLSDFGES-EYMVDKK 206 Query: 176 LTSVVVTLWYRAPEVL-LQSSY-ATPVDLWSVGCIFAEMFRRKPLFR-GSSDVDQLGKIL 232 + T + PE +SSY VD+WS+G MF F S V+ I Sbjct: 207 IKGSRGTYEFMPPEFFSNESSYNGAKVDIWSLGICLYVMFYNVVPFSLKISLVELFNNIR 266 Query: 233 DVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAY 292 ++P D +K + F+++ D D L L NPA+RI++ Sbjct: 267 -----TKNIEYPLDRNHFLYPLTNKKSTCSNNFLSNED---IDFLKLFLRKNPAERITSE 318 Query: 293 SALSHPYFQD 302 AL H + D Sbjct: 319 DALKHEWLAD 328 >6HV0-A nrPDB Length = 416 Score = 176 bits (447), Expect = 1e-44, Method: Composition-based stats. Identities = 84/301 (27%), Positives = 129/301 (42%), Gaps = 52/301 (17%) Query: 18 EIGEGAYGK-VFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNV 76 +G GA G V++ R VA+KR+ + REV +LR + EHPNV Sbjct: 15 VLGHGAEGTIVYRGMF---DNRDVAVKRILPECFS-----FADREVQLLRE--SDEHPNV 64 Query: 77 VRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFL 136 +R F CT + + E L Y+++ + E I ++ Q GL L Sbjct: 65 IRYF--CTEKDRQFQ---YIAIELCAATLQEYVEQKDFAHLGLEPI-TLLQQTTSGLAHL 118 Query: 137 HSHRVVHRDLKPQNILV---TSSGQIK--LADFGLARIYSFQMA----LTSVVVTLWYRA 187 HS +VHRDLKP NIL+ + G+IK ++DFGL + + + V T + A Sbjct: 119 HSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIA 178 Query: 188 PEVLLQ---SSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWP 244 PE+L + + VD++S GC+F + G S Q +L L Sbjct: 179 PEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANILLGACSL------- 231 Query: 245 RDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLE 304 H + + D + ++L+ K + +P KR SA L HP+F LE Sbjct: 232 -------DCLHPEKHE---------DVIARELIEKMIAMDPQKRPSAKHVLKHPFFWSLE 275 Query: 305 R 305 + Sbjct: 276 K 276 >6J5U-C nrPDB Length = 426 Score = 176 bits (446), Expect = 1e-44, Method: Composition-based stats. Identities = 69/305 (22%), Positives = 114/305 (37%), Gaps = 35/305 (11%) Query: 6 LCRADQQYECVAEIGEGAYGKVFKARDLKNG--------GRFVALKRVRVQTGEEGMPLS 57 L A + + +GEG +G VFK + G VA+K+++ + + Sbjct: 79 LKNATKNFRQDNLLGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQLKPEGFQ--GHKE 136 Query: 58 TIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPG 116 + EV L L HPN+V L C LV+E + L +L + Sbjct: 137 WLTEVNYLGQLS---HPNLVLLVGYCAEGENR-----LLVYEFMPKGSLENHLFRRGAQP 188 Query: 117 VPTETIKDMMFQLLRGLDFLHSHR--VVHRDLKPQNILVTSSGQIKLADFGLARIYSFQM 174 + + +GL FLH + V++RD K NIL+ + KL+DFGLA+ Sbjct: 189 LTWAIRMKVAVGAAKGLTFLHEAKSQVIYRDFKAANILLDADFNAKLSDFGLAKAGPTGD 248 Query: 175 AL---TSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKI 231 T V+ T Y APE + D++S G + E+ + S+ ++ + Sbjct: 249 NTHVSTKVIGTHGYAAPEYVATGRLTAKSDVYSFGVVLLELISGRRAMDNSNGGNEYSLV 308 Query: 232 LDVIGLPGEEDWPRDV-ALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRIS 290 DW R+ F + ++ +L L+CL + R Sbjct: 309 ----------DWATPYLGDKRKLFRIMDTKLGGQYPQKGAFTAANLALQCLNPDAKLRPK 358 Query: 291 AYSAL 295 L Sbjct: 359 MSEVL 363 >5UIU-A nrPDB Length = 323 Score = 176 bits (446), Expect = 1e-44, Method: Composition-based stats. Identities = 65/286 (22%), Positives = 106/286 (37%), Gaps = 31/286 (10%) Query: 18 EIGEGAYGKVFKARDLKNGGRFVALKRVR--VQTGEEGMPLSTIREVAVLRHLETFEHPN 75 ++GEG +G V+K VA+K++ V E + +E+ V+ + H N Sbjct: 54 KMGEGGFGVVYKGYVNNTT---VAVKKLAAMVDITTEELKQQFDQEIKVMAKCQ---HEN 107 Query: 76 VVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLD-KVPEPGVPTETIKDMMFQLLRGL 133 +V L + L LV+ ++ + L L P + + G+ Sbjct: 108 LVELLGF-----SSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGI 162 Query: 134 DFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYS--FQMALTSV-VVTLWYRAPEV 190 +FLH + +HRD+K NIL+ + K++DFGLAR Q +TS V T Y APE Sbjct: 163 NFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEA 222 Query: 191 LLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALP 250 L D++S G + E+ P + L L +E+ + Sbjct: 223 LRGEI-TPKSDIYSFGVVLLEIITGLPAVDEHREPQLL--------LDIKEEIEDEEKTI 273 Query: 251 RQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALS 296 K V + + +CL KR Sbjct: 274 EDYIDKKMNDADSTSVEAMYSVA----SQCLHEKKNKRPDIKKVQQ 315 >2RIO-A nrPDB Length = 434 Score = 174 bits (442), Expect = 4e-44, Method: Composition-based stats. Identities = 77/341 (22%), Positives = 136/341 (39%), Gaps = 76/341 (22%) Query: 17 AEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNV 76 +G G+ G V GR VA+KR+ + + + E+ +L + +HPNV Sbjct: 21 KILGYGSSGTV--VFQGSFQGRPVAVKRMLIDFCD-----IALMEIKLLTE--SDDHPNV 71 Query: 77 VRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDM-----MFQLLR 131 +R + T R L + E + +L ++ + K+ + Q+ Sbjct: 72 IRYYCSETTDRF-----LYIALELCNLNLQDLVESKNVSDENLKLQKEYNPISLLRQIAS 126 Query: 132 GLDFLHSHRVVHRDLKPQNILVT-------------SSGQIKLADFGLARIY-----SFQ 173 G+ LHS +++HRDLKPQNILV+ + +I ++DFGL + SF+ Sbjct: 127 GVAHLHSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFR 186 Query: 174 MALTSVVVTLWYRAPEVLLQ-------SSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDV 225 L + T +RAPE+L + +D++S+GC+F + K F Sbjct: 187 TNLNNPSGTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPF------ 240 Query: 226 DQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNP 285 + + R+ + R F + + + DL+ + + +P Sbjct: 241 --------------GDKYSRESNIIRGIFSLDEMKCLHD--RSLIAEATDLISQMIDHDP 284 Query: 286 AKRISAYSALSHPYFQDLERCKE---------NLDSHLPPS 317 KR +A L HP F + E +++ PPS Sbjct: 285 LKRPTAMKVLRHPLFWPKSKKLEFLLKVSDRLEIENRDPPS 325 >4YFF-A nrPDB Length = 311 Score = 174 bits (441), Expect = 5e-44, Method: Composition-based stats. Identities = 54/215 (25%), Positives = 95/215 (44%), Gaps = 16/215 (7%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQT-GEEGMPLSTIREVAVLRHLE 69 + E IG G++GKV+K R + VA+KR R T + REV++L L Sbjct: 42 SEIEFHEIIGSGSFGKVYKGRCR---NKIVAIKRYRANTYCSKSDVDMFCREVSILCQL- 97 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQL 129 HP V++ C + ++ +V +++ L + + ++ + + Sbjct: 98 --NHPCVIQFVGACL----NDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDV 151 Query: 130 LRGLDFLHS--HRVVHRDLKPQNILVTSSGQIKLADFGLARIYS--FQMALTSVVVTLWY 185 +G+++LH+ ++HRDL NIL+ G +ADFG +R + +T L + Sbjct: 152 AKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRW 211 Query: 186 RAPEVLLQS-SYATPVDLWSVGCIFAEMFRRKPLF 219 APEV Q Y D++S E+ + F Sbjct: 212 MAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPF 246 >4TPT-A nrPDB Length = 303 Score = 172 bits (437), Expect = 2e-43, Method: Composition-based stats. Identities = 53/221 (23%), Positives = 96/221 (43%), Gaps = 33/221 (14%) Query: 16 VAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPN 75 +G+G +G+ K G V + +R +E + + EV V+R L +HPN Sbjct: 5 GEVLGKGFFGQAIKVTHKATGKVMVMKELIR---CDEETQKTFLTEVKVMRSL---DHPN 58 Query: 76 VVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDF 135 V++ V ++ KL L+ E+++ + +P P + + G+ + Sbjct: 59 VLKFIGVLY-----KDKKLNLLTEYIEGGTLKDFLRSMDP-FPWQQKVRFAKGIASGMAY 112 Query: 136 LHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY---------------------SFQM 174 LHS ++HRDL N L+ + +ADFGL+R+ + + Sbjct: 113 LHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRK 172 Query: 175 ALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRR 215 +VV ++ APE+L SY VD++S G + E+ + Sbjct: 173 KRYTVVGNPYWMAPEMLNGKSYDETVDIFSFGIVLCEIIGQ 213 >3AOX-A nrPDB Length = 344 Score = 172 bits (436), Expect = 2e-43, Method: Composition-based stats. Identities = 54/307 (17%), Positives = 109/307 (35%), Gaps = 52/307 (16%) Query: 7 CRADQQYECVAEIGEGAYGKVFKAR----DLKNGGRFVALKRVRVQTGEEGMPLSTIREV 62 + + +G GA+G+V++ + VA+K + E+ L + E Sbjct: 43 EVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDE-LDFLMEA 101 Query: 63 AVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEP-----G 116 ++ F H N+VR V S ++ E + DL ++L + Sbjct: 102 LIISK---FNHQNIVRCIGVSLQSLPR-----FILLELMAGGDLKSFLRETRPRPSQPSS 153 Query: 117 VPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSG---QIKLADFGLARIY--- 170 + + + + G +L + +HRD+ +N L+T G K+ DFG+AR Sbjct: 154 LAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRA 213 Query: 171 SFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLG 229 S+ ++ + + PE ++ + + D WS G + E+F + S+ + L Sbjct: 214 SYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLE 273 Query: 230 KILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRI 289 + + ++ P V ++ +C P R Sbjct: 274 FVTSGGRMDPPKNCPGPVYR--------------------------IMTQCWQHQPEDRP 307 Query: 290 SAYSALS 296 + L Sbjct: 308 NFAIILE 314 >3MY0-A nrPDB Length = 305 Score = 171 bits (433), Expect = 5e-43, Method: Composition-based stats. Identities = 68/307 (22%), Positives = 116/307 (37%), Gaps = 58/307 (18%) Query: 15 CVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHP 74 V +G+G YG+V++ G VA+K + + + I +LR H Sbjct: 12 LVECVGKGRYGEVWRGLWH---GESVAVKIFSSRDEQSWFRETEIYNTVLLR------HD 62 Query: 75 NVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPGVPTETIKDMMFQLLRGL 133 N++ SR T+L L+ + + L +L + + + GL Sbjct: 63 NILGFIASDMTSRNSS-TQLWLITHYHEHGSLYDFLQR---QTLEPHLALRLAVSAACGL 118 Query: 134 DFLH--------SHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMAL-----TSVV 180 LH + HRD K +N+LV S+ Q +AD GLA ++S V Sbjct: 119 AHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRV 178 Query: 181 VTLWYRAPEVLLQSSYA------TPVDLWSVGCIFAEMFRR----------KPLFRGSSD 224 T Y APEVL + D+W+ G + E+ RR +P F Sbjct: 179 GTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVP 238 Query: 225 VDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFN 284 D P ED + V + +Q + + ++ + ++ ++ C N Sbjct: 239 ND-----------PSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRE----CWYPN 283 Query: 285 PAKRISA 291 P+ R++A Sbjct: 284 PSARLTA 290 >3MDY-A nrPDB Length = 337 Score = 170 bits (431), Expect = 7e-43, Method: Composition-based stats. Identities = 76/307 (24%), Positives = 126/307 (41%), Gaps = 50/307 (16%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 +Q + V +IG+G YG+V+ + G VA+K + I + ++R Sbjct: 37 KQIQMVKQIGKGRYGEVWMGKWR---GEKVAVKVFFTTEEASWFRETEIYQTVLMR---- 89 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPGVPTETIKDMMFQL 129 H N++ + T T+L L+ ++ + L YL + +++ + + Sbjct: 90 --HENILGFIAA-DIKGTGSWTQLYLITDYHENGSLYDYLKSTT---LDAKSMLKLAYSS 143 Query: 130 LRGLDFLHSH--------RVVHRDLKPQNILVTSSGQIKLADFGLARIY-----SFQMAL 176 + GL LH+ + HRDLK +NILV +G +AD GLA + + Sbjct: 144 VSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPP 203 Query: 177 TSVVVTLWYRAPEVLLQ-------SSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLG 229 + V T Y PEVL + SY D++S G I E+ RR G Sbjct: 204 NTRVGTKRYMPPEVLDESLNRNHFQSY-IMADMYSFGLILWEVARRC----------VSG 252 Query: 230 KILDVIGLPGEEDWPRDVALP--RQAFHSKSAQPIEKFVTDIDELGKD---LLLKCLTFN 284 I++ LP + P D + R+ K +P DE + L+ +C N Sbjct: 253 GIVEEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHN 312 Query: 285 PAKRISA 291 PA R++A Sbjct: 313 PASRLTA 319 >5WNL-A nrPDB Length = 342 Score = 170 bits (431), Expect = 8e-43, Method: Composition-based stats. Identities = 57/287 (19%), Positives = 124/287 (43%), Gaps = 42/287 (14%) Query: 17 AEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNV 76 ++G G +G+V+K R + + ++A+K ++ + + E + +E + + Sbjct: 26 EKVGSGGFGQVYKVRHV-HWKTWLAIKCSPSLHVDDRERMELLEEA---KKMEMAKFRYI 81 Query: 77 VRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDF 135 + ++ +C + + LV E+++ L L P +P + ++ + G++F Sbjct: 82 LPVYGIC-------QEPVGLVMEYMETGSLEKLLASEP---LPWDLRFRIVHETAVGMNF 131 Query: 136 LH--SHRVVHRDLKPQNILVTSSGQIKLADFGLARI----YSFQMALTSVVVTLWYRAPE 189 LH S ++H +LKP NIL+ + +K++DFGLA+ +S +++ + T+ Y PE Sbjct: 132 LHCMSPPLLHLNLKPANILLDAHYHVKISDFGLAKCNGMSHSHDLSMDGLFGTIAYLPPE 191 Query: 190 VLLQSS--YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDV 247 + + S + T D++S + + +K F + + + L ++ V+ E P Sbjct: 192 RIREKSRLFDTKHDVYSFAIVIWGVLTQKKPF--ADEKNILHIMMKVVKGHRPELPPICR 249 Query: 248 ALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSA 294 PR L+ +C +P R + Sbjct: 250 PRPRAC-----------------ASLIGLMQRCWHADPQVRPTFQEI 279 >5LPZ-A nrPDB Length = 332 Score = 170 bits (430), Expect = 1e-42, Method: Composition-based stats. Identities = 56/222 (25%), Positives = 102/222 (45%), Gaps = 21/222 (9%) Query: 6 LCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVL 65 L +A + + IG G +G V+KA G VA+K++ +G+ +A + Sbjct: 12 LLQATNGFHNDSLIGSGGFGDVYKAILK--DGSAVAIKKLIHVSGQGDREF-----MAEM 64 Query: 66 RHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPG--VPTETI 122 + +H N+V L C V + LV+E + L L + G + T Sbjct: 65 ETIGKIKHRNLVPLLGYCKVG-----DERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTR 119 Query: 123 KDMMFQLLRGLDFLHSH---RVVHRDLKPQNILVTSSGQIKLADFGLARIYS---FQMAL 176 + + RGL FLH + ++HRD+K N+L+ + + +++DFG+AR+ S +++ Sbjct: 120 RKIAIGSARGLAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSV 179 Query: 177 TSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPL 218 +++ T Y PE +T D++S G + E+ K Sbjct: 180 STLAGTPGYVPPEYYQSFRCSTKGDVYSYGVVLLELLTGKRP 221 >5LPV-A nrPDB Length = 296 Score = 169 bits (428), Expect = 2e-42, Method: Composition-based stats. Identities = 56/222 (25%), Positives = 102/222 (45%), Gaps = 21/222 (9%) Query: 6 LCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVL 65 L +A + + IG G +G V+KA G VA+K++ +G+ +A + Sbjct: 12 LLQATNGFHNDSLIGSGGFGDVYKAILK--DGSAVAIKKLIHVSGQGDREF-----MAEM 64 Query: 66 RHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPG--VPTETI 122 + +H N+V L C V + LV+E + L L + G + T Sbjct: 65 ETIGKIKHRNLVPLLGYCKVG-----DERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTR 119 Query: 123 KDMMFQLLRGLDFLHSH---RVVHRDLKPQNILVTSSGQIKLADFGLARIYS---FQMAL 176 + + RGL FLH + ++HRD+K N+L+ + + +++DFG+AR+ S +++ Sbjct: 120 RKIAIGSARGLAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSV 179 Query: 177 TSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPL 218 +++ T Y PE +T D++S G + E+ K Sbjct: 180 STLAGTPGYVPPEYYQSFRCSTKGDVYSYGVVLLELLTGKRP 221 >5IKW-A nrPDB Length = 310 Score = 169 bits (428), Expect = 2e-42, Method: Composition-based stats. Identities = 65/296 (21%), Positives = 113/296 (38%), Gaps = 51/296 (17%) Query: 14 ECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEH 73 + EG + VF R +GG ALKR+ V + RE+ +++ L H Sbjct: 17 TLEESLAEGGFSTVFLVR--THGGIRCALKRMYVNNMPDLNVCK--REITIMKELSG--H 70 Query: 74 PNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPGVPTETIKDMMFQLLRG 132 N+V D S +D ++ ++ E+ + ++K + G + + Sbjct: 71 KNIVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEA 130 Query: 133 LDFLHSHR--VVHRDLKPQNILVTSSGQIKLADFGLA--RIYSFQMALTSVV-------V 181 + LH + ++HRDLK +NIL+ G L DFG A + + Q +VV Sbjct: 131 VARLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYT 190 Query: 182 TLWYRAPEVLL---QSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLP 238 TL YRAPE++ T D+W++GC+ ++ F G S V Sbjct: 191 TLSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPF-GESQVAI----------- 238 Query: 239 GEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSA 294 + +P + +S++ L+ L +P R + Sbjct: 239 ----CDGNFTIPDNSRYSRNIHC--------------LIRFMLEPDPEHRPDIFQV 276 >4NEU-A nrPDB Length = 333 Score = 168 bits (425), Expect = 4e-42, Method: Composition-based stats. Identities = 65/306 (21%), Positives = 108/306 (35%), Gaps = 49/306 (16%) Query: 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR 60 M + + + AE+ G +GKV G +K V + + Sbjct: 14 MSLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMI--MKTVYKGPNCIEHNEALLE 71 Query: 61 EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTE 120 E ++ L H VV+L V E K +LV E++++ ++ K E P Sbjct: 72 EAKMMNRLR---HSRVVKLLGVII-----EEGKYSLVMEYMEKGNLMHVLK-AEMSTPLS 122 Query: 121 TIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLA------------- 167 ++ +++ G+ +LH V+H+DLKP+NILV + IK+AD GLA Sbjct: 123 VKGRIILEIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEH 182 Query: 168 -RIYSFQMALTSVVVTLWYRAPEVLLQ--SSYATPVDLWSVGCIFAEMFRRKPLFRGSSD 224 + TL+Y APE L + D++S + +F K + + Sbjct: 183 NELREVDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAIC 242 Query: 225 VDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFN 284 QL + P +D L+ C N Sbjct: 243 EQQLIMCIKSGNRPDVDDITEY----------------------CPREIISLMKLCWEAN 280 Query: 285 PAKRIS 290 P R + Sbjct: 281 PEARPT 286 >2QKW-B nrPDB Length = 321 Score = 167 bits (423), Expect = 6e-42, Method: Composition-based stats. Identities = 66/296 (22%), Positives = 115/296 (38%), Gaps = 28/296 (9%) Query: 6 LCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVL 65 L A ++ IG G +GKV+K G VALKR ++ + T Sbjct: 34 LEEATNNFDHKFLIGHGVFGKVYKGVLR--DGAKVALKRRTPESSQGIEEFETEI----- 86 Query: 66 RHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYL--DKVPEPGVPTETI 122 L HP++V L C D ++ L++++++ +L +L +P + E Sbjct: 87 ETLSFCRHPHLVSLIGFC-----DERNEMILIYKYMENGNLKRHLYGSDLPTMSMSWEQR 141 Query: 123 KDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLAR---IYSFQMALTSV 179 ++ RGL +LH+ ++HRD+K NIL+ + K+ DFG+++ T V Sbjct: 142 LEICIGAARGLHYLHTRAIIHRDVKSINILLDENFVPKITDFGISKKGTELDQTHLSTVV 201 Query: 180 VVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPG 239 TL Y PE ++ D++S G + E+ + S + + Sbjct: 202 KGTLGYIDPEYFIKGRLTEKSDVYSFGVVLFEVLCARSAIVQSLPREMVNL--------- 252 Query: 240 EEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSAL 295 +W + Q +K + D +KCL + R S L Sbjct: 253 -AEWAVESHNNGQLEQIVDPNLADKIRPESLRKFGDTAVKCLALSSEDRPSMGDVL 307 >4IDT-A nrPDB Length = 356 Score = 167 bits (422), Expect = 7e-42, Method: Composition-based stats. Identities = 67/321 (20%), Positives = 112/321 (34%), Gaps = 66/321 (20%) Query: 18 EIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVV 77 +G G++G+V + D + G + A+K+VR++ L P +V Sbjct: 81 RLGRGSFGEVHRMEDKQTGFQ-CAVKKVRLEVFR----------AEELMACAGLTSPRIV 129 Query: 78 RLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLH 137 L+ + + E ++ L K + +P + + Q L GL++LH Sbjct: 130 PLYGAVREGPW-----VNIFMELLEGGSLGQLVK-EQGCLPEDRALYYLGQALEGLEYLH 183 Query: 138 SHRVVHRDLKPQNILVTSSG-QIKLADFGLARIYSFQMALTSVV------VTLWYRAPEV 190 S R++H D+K N+L++S G L DFG A ++ T + APEV Sbjct: 184 SRRILHGDVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKDLLTGDYIPGTETHMAPEV 243 Query: 191 LLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALP 250 +L S VD+WS C+ M W + P Sbjct: 244 VLGRSCDAKVDVWSSCCMMLHMLNGCHP------------------------WTQFFRGP 279 Query: 251 RQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSA-------------LSH 297 + P+ + L + + L P R+SA L Sbjct: 280 LCLKIASEPPPVREIPPSCAPLTAQAIQEGLRKEPIHRVSAAELGGKVNRALQQVGGLKS 339 Query: 298 PYFQDLERCKENLDSHLPPSQ 318 P+ R + H PP+Q Sbjct: 340 PW-----RGEYKEPRHPPPNQ 355 >5TE0-A nrPDB Length = 347 Score = 166 bits (420), Expect = 1e-41, Method: Composition-based stats. Identities = 70/329 (21%), Positives = 117/329 (35%), Gaps = 58/329 (17%) Query: 8 RADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRH 67 QQ + EG + VF R + G ALKR+ V + RE+ ++R Sbjct: 16 IGRQQVTVDEVLAEGGFAIVFLVR--TSNGMKCALKRMFVNNEHDLQVCK--REIQIMRD 71 Query: 68 LETFEHPNVVRLFDV-CTVSRTDRETKLTLVFEHVDQD-LTTYLDKVPEPGVPTETIKDM 125 L H N+V D + ++ ++ + + +++ + G + + Sbjct: 72 LSG--HKNIVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQI 129 Query: 126 MFQLLRGLDFLHSHR--VVHRDLKPQNILVTSSGQIKLADFGLA--RIYSFQMALTSVV- 180 + LH + ++HRDLK +NIL+ G L DFG A + + Q + V Sbjct: 130 FCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVE 189 Query: 181 ------VTLWYRAPEVLL---QSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKI 231 TL YRAPE++ T D+W++GC+ ++ F G S V Sbjct: 190 DEIKKYTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPF-GESQVAI---- 244 Query: 232 LDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISA 291 + +P + + L+ L +P KR Sbjct: 245 -----------CDGNFTIPDN--------------SRYSQDMHCLIRYMLEPDPDKRPDI 279 Query: 292 YSALSHPYFQDLERCKENLDSHLPPSQNT 320 Y YF KE +P QN+ Sbjct: 280 YQV---SYFSFKLLKKE---CPIPNVQNS 302 >2BUJ-A nrPDB Length = 317 Score = 165 bits (419), Expect = 2e-41, Method: Composition-based stats. Identities = 73/310 (23%), Positives = 121/310 (39%), Gaps = 51/310 (16%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLE 69 ++ Y + ++GEG + V L + G F ALKR+ E+ RE + R Sbjct: 28 NKHYLFIQKLGEGGFSYVDLVEGL-HDGHFYALKRI--LCHEQQDREEAQREADMHR--- 81 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPG--VPTETIKDMMF 127 F HPN++RL C R + L+ L ++++ + G + + I ++ Sbjct: 82 LFNHPNILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFLTEDQILWLLL 141 Query: 128 QLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGL----------ARIYSFQMALT 177 + RGL+ +H+ HRDLKP NIL+ GQ L D G +R Sbjct: 142 GICRGLEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSRQALTLQDWA 201 Query: 178 SVVVTLWYRAPEVLLQSSY---ATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDV 234 + T+ YRAPE+ S+ D+WS+GC+ M + + ++ Sbjct: 202 AQRCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPYD----------MVFQ 251 Query: 235 IGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRI----- 289 G +++P+ HS + LL +T +P +R Sbjct: 252 KGDSVALAVQNQLSIPQSPRHSSALWQ--------------LLNSMMTVDPHQRPHIPLL 297 Query: 290 -SAYSALSHP 298 S AL P Sbjct: 298 LSQLEALQPP 307 >5WNO-A nrPDB Length = 330 Score = 165 bits (419), Expect = 2e-41, Method: Composition-based stats. Identities = 58/288 (20%), Positives = 110/288 (38%), Gaps = 47/288 (16%) Query: 14 ECVAEIGEGAYGKVFKARDL----KNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLE 69 + ++G GA+G VF KN VA+K ++ + E + L Sbjct: 25 KLDKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVF---QTDQSQTDEMLEEATNMFRLR 81 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPGVPTETIKDMMFQ 128 H N++++ C + L +V + +L +L K+ + + +Q Sbjct: 82 ---HDNLLKIIGFCM-----HDDGLKIVTIYRPLGNLQNFL-KLHKENLGAREQVLYCYQ 132 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQ---MALTSVVVTLWY 185 + G+ +L RVVHRDL +N+LV +++ DFGL++I + + S V + + Sbjct: 133 IASGMQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKW 192 Query: 186 RAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILDVIGLPGEEDWP 244 A E+ + Y D+W+ G E+ + ++G S + D L + Sbjct: 193 LAIEIFSKHCYTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQPPNCS 252 Query: 245 RDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAY 292 +D+ ++LL +C +P R Sbjct: 253 QDLY-------------------------QELL-RCWMADPKSRPGFE 274 >3UIM-A nrPDB Length = 326 Score = 165 bits (418), Expect = 3e-41, Method: Composition-based stats. Identities = 70/299 (23%), Positives = 128/299 (42%), Gaps = 27/299 (9%) Query: 6 LCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVL 65 L A + +G G +GKV+K R G VA+KR++ + +G L EV + Sbjct: 25 LQVASDNFSNKNILGRGGFGKVYKGRLA--DGTLVAVKRLKEERT-QGGELQFQTEVEM- 80 Query: 66 RHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPE--PGVPTETI 122 + H N++RL C LV+ ++ + + + L + PE P + Sbjct: 81 --ISMAVHRNLLRLRGFCMTPTER-----LLVYPYMANGSVASCLRERPESQPPLDWPKR 133 Query: 123 KDMMFQLLRGLDFLHSH---RVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQ--MALT 177 + + RGL +LH H +++HRD+K NIL+ + + DFGLA++ ++ T Sbjct: 134 QRIALGSARGLAYLHDHCDPKIIHRDVKAANILLDEEFEAVVGDFGLAKLMDYKDTHVTT 193 Query: 178 SVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGL 237 +V T+ + APE L + D++ G + E+ + F D+ +L DV+ L Sbjct: 194 AVRGTIGHIAPEYLSTGKSSEKTDVFGYGVMLLELITGQRAF----DLARLANDDDVMLL 249 Query: 238 PGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALS 296 + ++ L ++ V + ++ LL C +P +R + Sbjct: 250 DWVKGLLKEKKLEALVDVDLQGNYKDEEVEQLIQVA--LL--CTQSSPMERPKMSEVVR 304 >3G2F-A nrPDB Length = 336 Score = 164 bits (416), Expect = 4e-41, Method: Composition-based stats. Identities = 78/310 (25%), Positives = 123/310 (39%), Gaps = 43/310 (13%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 + + IG G YG V+K R VA+K + + I V ++ Sbjct: 13 DNLKLLELIGRGRYGAVYKG---SLDERPVAVKVFSFANRQNFINEKNIYRVPLM----- 64 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPGVPTETIKDMMFQL 129 EH N+ R D + LV E+ + L YL V + + + Sbjct: 65 -EHDNIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSS---CRLAHSV 120 Query: 130 LRGLDFLHSH---------RVVHRDLKPQNILVTSSGQIKLADFGLA---------RIYS 171 RGL +LH+ + HRDL +N+LV + G ++DFGL+ R Sbjct: 121 TRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPGE 180 Query: 172 FQMALTSVVVTLWYRAPEVLLQ-------SSYATPVDLWSVGCIFAEMFRRKP-LFRGSS 223 A S V T+ Y APEVL S VD++++G I+ E+F R LF G S Sbjct: 181 EDNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGES 240 Query: 224 DVD-QLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLT 282 + Q+ +V P ED V + R+ K + ++ + L K+ + C Sbjct: 241 VPEYQMAFQTEVGNHPTFEDM--QVLVSREKQRPKFPEAWKENSLAVRSL-KETIEDCWD 297 Query: 283 FNPAKRISAY 292 + R++A Sbjct: 298 QDAEARLTAQ 307 >3LMG-A nrPDB Length = 344 Score = 163 bits (412), Expect = 1e-40, Method: Composition-based stats. Identities = 55/280 (19%), Positives = 112/280 (40%), Gaps = 25/280 (8%) Query: 14 ECVAEIGEGAYGKVFKARDLKNGGRF---VALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 + +G G +G V K + G V +K + ++G + T +A+ + Sbjct: 34 RKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAI----GS 89 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPGVPTETIKDMMFQL 129 +H ++VRL +C S L LV +++ L ++ + + + + + Q+ Sbjct: 90 LDHAHIVRLLGLCPGSS------LQLVTQYLPLGSLLDHVRQ-HRGALGPQLLLNWGVQI 142 Query: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMA---LTSVVVTLWYR 186 +G+ +L H +VHR+L +N+L+ S Q+++ADFG+A + + + + Sbjct: 143 AKGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWM 202 Query: 187 APEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILDVIGLPGEEDWPR 245 A E + Y D+WS G E+ + G +L ++ D++ P+ Sbjct: 203 ALESIHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGL----RLAEVPDLLEKGERLAQPQ 258 Query: 246 DVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNP 285 + K E EL + + +P Sbjct: 259 ICTIDVYMVMVKCWMIDENIRPTFKELANEF-TRM-ARDP 296 >3SOC-A nrPDB Length = 322 Score = 162 bits (409), Expect = 3e-40, Method: Composition-based stats. Identities = 61/299 (20%), Positives = 113/299 (37%), Gaps = 40/299 (13%) Query: 14 ECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEH 73 + + G +G V+KA+ L +VA+K +Q + + + ++ H Sbjct: 27 QLLEVKARGRFGCVWKAQLL---NEYVAVKIFPIQDKQSWQNEYEVYSLPGMK------H 77 Query: 74 PNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPGVPTETIKDMMFQLLRG 132 N+++ T + L L+ + L+ +L V + + + RG Sbjct: 78 ENILQFIGA-EKRGTSVDVDLWLITAFHEKGSLSDFLKAN---VVSWNELCHIAETMARG 133 Query: 133 LDFLHS----------HRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMA---LTSV 179 L +LH + HRD+K +N+L+ ++ +ADFGLA + + Sbjct: 134 LAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQ 193 Query: 180 VVTLWYRAPEVL-----LQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDV 234 V T Y APEVL Q +D++++G + E+ R G D L ++ Sbjct: 194 VGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEI 253 Query: 235 IGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELG--KDLLLKCLTFNPAKRISA 291 P ED V H K + + + + + +C + R+SA Sbjct: 254 GQHPSLEDMQEVV------VHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSA 306 >4F0G-A nrPDB Length = 287 Score = 160 bits (406), Expect = 5e-40, Method: Composition-based stats. Identities = 65/299 (21%), Positives = 117/299 (39%), Gaps = 58/299 (19%) Query: 9 ADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPL-----STIREVA 63 AD + E +IG+G +G V K R +K+ VA+K + + E + REV Sbjct: 17 ADNEIEYEKQIGKGGFGLVHKGRLVKD-KSVVAIKSLILGDSEGETEMIEKFQEFQREVF 75 Query: 64 VLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPGVPTETI 122 ++ +L HPN+V+L+ + +V E V DL L P + Sbjct: 76 IMSNL---NHPNIVKLYGLMHNPPR-------MVMEFVPCGDLYHRLLDKAHP-IKWSVK 124 Query: 123 KDMMFQLLRGLDFLHSHR--VVHRDLKPQNILV---TSSGQI--KLADFGLARIYSFQMA 175 +M + G++++ + +VHRDL+ NI + + + K+ADFGL++ Sbjct: 125 LRLMLDIALGIEYMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQSVHS-- 182 Query: 176 LTSVVVTLWYRAPEVL--LQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQ--LGKI 231 ++ ++ + APE + + SY D +S I + + F S + I Sbjct: 183 VSGLLGNFQWMAPETIGAEEESYTEKADTYSFAMILYTILTGEGPFDEYSYGKIKFINMI 242 Query: 232 LDVIGLPG-EEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRI 289 + P ED P ++++ C + +P KR Sbjct: 243 REEGLRPTIPEDCP--------------------------PRLRNVIELCWSGDPKKRP 275 >3QD2-B nrPDB Length = 332 Score = 160 bits (404), Expect = 9e-40, Method: Composition-based stats. Identities = 65/338 (19%), Positives = 120/338 (35%), Gaps = 82/338 (24%) Query: 8 RADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRH 67 R +E + +G G +G VF+A++ + A+KR+R+ E +REV L Sbjct: 3 RYLTDFEPIQCMGRGGFGVVFEAKNKVDDCN-YAIKRIRLPN-RELAREKVMREVKALAK 60 Query: 68 LETFEHPNVVRLFDVCTVSRTDRETK---------------------------------- 93 L EHP +VR F+ + ++ + Sbjct: 61 L---EHPGIVRYFNAWLETPPEKWQEEMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDP 117 Query: 94 ------------------LTLVFEHVDQD-LTTYLDKVPEPGVPTETI-KDMMFQLLRGL 133 L + + ++ L ++++ + + Q+ + Sbjct: 118 FSTKNTVGQLQPSSPKVYLYIQMQLCRKENLKDWMNRRCSLEDREHGVCLHIFIQIAEAV 177 Query: 134 DFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMA-------------LTSVV 180 +FLHS ++HRDLKP NI T +K+ DFGL T V Sbjct: 178 EFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQV 237 Query: 181 VTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGE 240 T Y +PE + ++Y+ VD++S+G I E+ + S+ ++++ I DV L Sbjct: 238 GTKLYMSPEQIHGNNYSHKVDIFSLGLILFELL-----YSFSTQMERVRIITDVRNLKFP 292 Query: 241 EDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLL 278 + + Q + D++ Sbjct: 293 LLF-----TQKYPQEHMMVQDMLSPSPTERPEATDIIE 325 >5XD6-A nrPDB Length = 305 Score = 159 bits (402), Expect = 2e-39, Method: Composition-based stats. Identities = 58/232 (25%), Positives = 95/232 (40%), Gaps = 27/232 (11%) Query: 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR 60 + D L Y + IGEG+YG+VF G+ A+K++ + L+ + Sbjct: 12 IPADELRDITDNYGSKSLIGEGSYGRVFYGILK--SGKAAAIKKLDSSKQPDQEFLAQVS 69 Query: 61 EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLD-------KV 112 V+ LR NVV L C L +E+ + L L Sbjct: 70 MVSRLRQ------ENVVALLGYCVDGPLR-----VLAYEYAPNGSLHDILHGRKGVKGAQ 118 Query: 113 PEPGVPTETIKDMMFQLLRGLDFLHSH---RVVHRDLKPQNILVTSSGQIKLADFGLARI 169 P P + + RGL++LH V+HRD+K N+L+ K+ADF L+ Sbjct: 119 PGPVLSWHQRVKIAVGAARGLEYLHEKANPHVIHRDIKSSNVLLFDDDVAKIADFDLSNQ 178 Query: 170 ---YSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPL 218 + ++ T V+ T Y APE + + +T D++S G + E+ + Sbjct: 179 APDMAARLHSTRVLGTFGYHAPEYAMTGTLSTKSDVYSFGVVLLELLTGRKP 230 >4JLC-A nrPDB Length = 657 Score = 158 bits (401), Expect = 2e-39, Method: Composition-based stats. Identities = 66/247 (26%), Positives = 106/247 (42%), Gaps = 28/247 (11%) Query: 6 LCRADQQ--YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVA 63 +C++ + +G+GA VF+ R K G A+K + + + +RE Sbjct: 1 ICQSTSNHLWLLSDILGQGATANVFRGRHKKTGD-LYAVKVFNNISFLRPVDVQ-MREFE 58 Query: 64 VLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEP-GVPTET 121 VL+ L H N+V+LF + + T + L+ E L T L++ G+P Sbjct: 59 VLKKL---NHKNIVKLFAIEEETTTRHK---VLIMEFCPCGSLYTVLEEPSNAYGLPESE 112 Query: 122 IKDMMFQLLRGLDFLHSHRVVHRDLKPQNIL--VTSSGQ--IKLADFGLARIYSFQMALT 177 ++ ++ G++ L + +VHRD+KP NI+ + GQ KL DFG AR Sbjct: 113 FLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFV 172 Query: 178 SVVVTLWYRAPEVLL--------QSSYATPVDLWSVGCIFAEMFRRKPLFR----GSSDV 225 S+ T Y P++ Q Y VDLWSVG F FR + Sbjct: 173 SLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSVGVTFYHAATGSLPFRPFEGPRRNK 232 Query: 226 DQLGKIL 232 + + KI+ Sbjct: 233 EVMYKII 239 >1PY5-A nrPDB Length = 326 Score = 158 bits (400), Expect = 3e-39, Method: Composition-based stats. Identities = 70/297 (23%), Positives = 119/297 (40%), Gaps = 38/297 (12%) Query: 15 CVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHP 74 IG+G +G+V++ + G VA+K + + I + +LR H Sbjct: 33 LQESIGKGRFGEVWRGKWR---GEEVAVKIFSSREERSWFREAEIYQTVMLR------HE 83 Query: 75 NVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPGVPTETIKDMMFQLLRGL 133 N++ T+L LV ++ + L YL++ V E + + GL Sbjct: 84 NILGFIAA-DNKDNGTWTQLWLVSDYHEHGSLFDYLNRYT---VTVEGMIKLALSTASGL 139 Query: 134 DFLH--------SHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSF-----QMALTSVV 180 LH + HRDLK +NILV +G +AD GLA + +A V Sbjct: 140 AHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRV 199 Query: 181 VTLWYRAPEVLLQS------SYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDV 234 T Y APEVL S D++++G +F E+ RR + G + QL V Sbjct: 200 GTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSI-GGIHEDYQLPYYDLV 258 Query: 235 IGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISA 291 P E+ + V + + + + + + ++ ++ C N A R++A Sbjct: 259 PSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRE----CWYANGAARLTA 311 >6O8B-A nrPDB Length = 665 Score = 157 bits (398), Expect = 5e-39, Method: Composition-based stats. Identities = 66/249 (26%), Positives = 108/249 (43%), Gaps = 28/249 (11%) Query: 4 DGLCRADQQ--YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIRE 61 DG+C++ + +G+GA VF+ R K G F A+K + + + +RE Sbjct: 6 DGICQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLF-AIKVFNNISFLRPVDVQ-MRE 63 Query: 62 VAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEP-GVPT 119 VL+ L H N+V+LF + + T + L+ E L T L++ G+P Sbjct: 64 FEVLKKL---NHKNIVKLFAIEEETTTRHK---VLIMEFCPCGSLYTVLEEPSNAYGLPE 117 Query: 120 ETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNIL--VTSSGQ--IKLADFGLARIYSFQMA 175 ++ ++ G++ L + +VHR++KP NI+ + GQ KL DFG AR Sbjct: 118 SEFLIVLRDVVGGMNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQ 177 Query: 176 LTSVVVTLWYRAPEVLL--------QSSYATPVDLWSVGCIFAEMFRRKPLFR----GSS 223 + T Y P++ Q Y VDLWS+G F FR Sbjct: 178 FVELYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRR 237 Query: 224 DVDQLGKIL 232 + + + KI+ Sbjct: 238 NKEVMYKII 246 >4EUU-A nrPDB Length = 319 Score = 157 bits (398), Expect = 5e-39, Method: Composition-based stats. Identities = 64/232 (27%), Positives = 102/232 (43%), Gaps = 26/232 (11%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVR 78 +G+GA VF+ R K G F A+K + + + +RE VL+ L H N+V+ Sbjct: 17 LGQGATANVFRGRHKKTGDLF-AIKVFNNISFLRPVDVQ-MREFEVLKKL---NHKNIVK 71 Query: 79 LFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEP-GVPTETIKDMMFQLLRGLDFL 136 LF + + T + L+ E L T L++ G+P ++ ++ G++ L Sbjct: 72 LFAIEEETTTRHK---VLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 128 Query: 137 HSHRVVHRDLKPQNIL--VTSSGQ--IKLADFGLARIYSFQMALTSVVVTLWYRAPEVLL 192 + +VHR++KP NI+ + GQ KL DFG AR S+ T Y P++ Sbjct: 129 RENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYE 188 Query: 193 --------QSSYATPVDLWSVGCIFAEMFRRKPLFR----GSSDVDQLGKIL 232 Q Y VDLWS+G F FR + + + KI+ Sbjct: 189 RAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKII 240 >4EUT-A nrPDB Length = 396 Score = 156 bits (394), Expect = 1e-38, Method: Composition-based stats. Identities = 64/232 (27%), Positives = 102/232 (43%), Gaps = 26/232 (11%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVR 78 +G+GA VF+ R K G F A+K + + + +RE VL+ L H N+V+ Sbjct: 17 LGQGATANVFRGRHKKTGDLF-AIKVFNNISFLRPVDVQ-MREFEVLKKL---NHKNIVK 71 Query: 79 LFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEP-GVPTETIKDMMFQLLRGLDFL 136 LF + + T + L+ E L T L++ G+P ++ ++ G++ L Sbjct: 72 LFAIEEETTTRHK---VLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 128 Query: 137 HSHRVVHRDLKPQNIL--VTSSGQ--IKLADFGLARIYSFQMALTSVVVTLWYRAPEVLL 192 + +VHR++KP NI+ + GQ KL DFG AR S+ T Y P++ Sbjct: 129 RENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYE 188 Query: 193 --------QSSYATPVDLWSVGCIFAEMFRRKPLFR----GSSDVDQLGKIL 232 Q Y VDLWS+G F FR + + + KI+ Sbjct: 189 RAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKII 240 >4G3E-A nrPDB Length = 352 Score = 155 bits (393), Expect = 2e-38, Method: Composition-based stats. Identities = 50/209 (23%), Positives = 89/209 (42%), Gaps = 24/209 (11%) Query: 18 EIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVV 77 +G G++G+V + +D + G + A+K+VR++ V L P +V Sbjct: 81 RVGRGSFGEVHRMKDKQTGFQ-CAVKKVRLEVFR----------VEELVACAGLSSPRIV 129 Query: 78 RLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLH 137 L+ + + E ++ L K +P + + Q L GL++LH Sbjct: 130 PLYGAVREGPW-----VNIFMELLEGGSLGQLIKQMGC-LPEDRALYYLGQALEGLEYLH 183 Query: 138 SHRVVHRDLKPQNILVTSSG-QIKLADFGLARIYSFQMALTSVV------VTLWYRAPEV 190 + R++H D+K N+L++S G + L DFG A S++ T + APEV Sbjct: 184 TRRILHGDVKADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAPEV 243 Query: 191 LLQSSYATPVDLWSVGCIFAEMFRRKPLF 219 ++ VD+WS C+ M + Sbjct: 244 VMGKPCDAKVDIWSSCCMMLHMLNGCHPW 272 >4F9B-A nrPDB Length = 361 Score = 155 bits (392), Expect = 2e-38, Method: Composition-based stats. Identities = 76/361 (21%), Positives = 135/361 (37%), Gaps = 76/361 (21%) Query: 4 DGLCRADQQYECVAEIGEGAYGKVFKARDLKNGG--RFVALKRVRVQTGEEGMPLSTIRE 61 + + + ++ +IGEG + V+ A G +ALK + P+ E Sbjct: 14 EAVPQLSNVFKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHL----IPTSHPIRIAAE 69 Query: 62 VAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTET 121 + L + NV+ + + + + +++ + ++LD + + + Sbjct: 70 LQCLTVAGGQD--NVMGVKYCF-----RKNDHVVIAMPYLEHE--SFLDILN--SLSFQE 118 Query: 122 IKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSS-GQIKLADFGLAR------------ 168 +++ M L + L +H +VHRD+KP N L + L DFGLA+ Sbjct: 119 VREYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKF 178 Query: 169 -----------------IYSFQMALTSVVVTLWYRAPEVLLQSS-YATPVDLWSVGCIFA 210 S + + T +RAPEVL + T +D+WS G IF Sbjct: 179 VQSEAQQERCSQNKCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFL 238 Query: 211 EMFRRKPLFR-GSSDVDQLGKILDVIGLP---------------------------GEED 242 + + F S D+ L +I+ + G E Sbjct: 239 SLLSGRYPFYKASDDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERL 298 Query: 243 WPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQD 302 D + P+ + + ++ + DLL K L NPA RI+A AL HP+F+D Sbjct: 299 RGMDSSTPKLTSDIQGHATNLEGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFFKD 358 Query: 303 L 303 + Sbjct: 359 M 359 >5AR8-A nrPDB Length = 326 Score = 153 bits (388), Expect = 8e-38, Method: Composition-based stats. Identities = 67/316 (21%), Positives = 118/316 (37%), Gaps = 50/316 (15%) Query: 1 MEKDGLCR--ADQQYECV---AEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGE-EGM 54 M + +C Y + + GA G V AR + VA+K + + T + Sbjct: 17 MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARH-ADWRVQVAVKHLHIHTPLLDSE 75 Query: 55 PLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVP 113 +RE +L ++ + +C + L +V E++ + L L + Sbjct: 76 RKDVLREAEILHKARFS---YILPILGIC-----NEPEFLGIVTEYMPNGSLNELLHRKT 127 Query: 114 E-PGVPTETIKDMMFQLLRGLDFLHSHR--VVHRDLKPQNILVTSSGQIKLADFGLAR-- 168 E P V ++ ++ G+++LH+ ++H DLK QNIL+ + +K+ADFGL++ Sbjct: 128 EYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWR 187 Query: 169 ----IYSFQMALTSVVVTLWYRAPEVL---LQSSYATPVDLWSVGCIFAEMFRRKPLFRG 221 S T+ Y PE +S + D++S I E+ RK F Sbjct: 188 MMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFED 247 Query: 222 SSDVDQLGKILDVIGLP--GEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLK 279 ++ Q+ + P EE P D+ + L+ Sbjct: 248 VTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMIS--------------------LIES 287 Query: 280 CLTFNPAKRISAYSAL 295 NP +R S L Sbjct: 288 GWAQNPDERPSFLKCL 303 >2H34-A nrPDB Length = 309 Score = 153 bits (387), Expect = 1e-37, Method: Composition-based stats. Identities = 64/262 (24%), Positives = 107/262 (40%), Gaps = 15/262 (5%) Query: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQ-TGEEGMPLSTIREVAVLRHLETF 71 Y +G G G V++A D R VALK + + + RE R Sbjct: 36 YRLRRLVGRGGMGDVYEAEDTVR-ERIVALKLMSETLSSDPVFRTRMQREA---RTAGRL 91 Query: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQLL 130 + P+VV + D + + +L + ++ DL L + + + ++ Q+ Sbjct: 92 QEPHVVPIHDF-----GEIDGQLYVDMRLINGVDLAAMLRR--QGPLAPPRAVAIVRQIG 144 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQM--ALTSVVVTLWYRAP 188 LD H+ HRD+KP+NILV++ L DFG+A + + L + V TL+Y AP Sbjct: 145 SALDAAHAAGATHRDVKPENILVSADDFAYLVDFGIASATTDEKLTQLGNTVGTLYYMAP 204 Query: 189 EVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA 248 E +S D++++ C+ E P ++G I I P VA Sbjct: 205 ERFSESHATYRADIYALTCVLYECLTGSPPYQGDQLSVMGAHINQAIPRPSTVRPGIPVA 264 Query: 249 LPRQAFHSKSAQPIEKFVTDID 270 + P +++VT D Sbjct: 265 FDAVIARGMAKNPEDRYVTCGD 286 >6NT9-A nrPDB Length = 742 Score = 153 bits (386), Expect = 1e-37, Method: Composition-based stats. Identities = 64/232 (27%), Positives = 102/232 (43%), Gaps = 26/232 (11%) Query: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVR 78 +G+GA VF+ R K G F A+K + + + +RE VL+ L H N+V+ Sbjct: 15 LGQGATANVFRGRHKKTGDLF-AIKVFNNISFLRPVDVQ-MREFEVLKKL---NHKNIVK 69 Query: 79 LFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEP-GVPTETIKDMMFQLLRGLDFL 136 LF + + T + L+ E L T L++ G+P ++ ++ G++ L Sbjct: 70 LFAIEEETTTRHK---VLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 126 Query: 137 HSHRVVHRDLKPQNIL--VTSSGQ--IKLADFGLARIYSFQMALTSVVVTLWYRAPEVLL 192 + +VHR++KP NI+ + GQ KL DFG AR S+ T Y P++ Sbjct: 127 RENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYE 186 Query: 193 --------QSSYATPVDLWSVGCIFAEMFRRKPLFR----GSSDVDQLGKIL 232 Q Y VDLWS+G F FR + + + KI+ Sbjct: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKII 238 >5E8V-A nrPDB Length = 316 Score = 153 bits (386), Expect = 1e-37, Method: Composition-based stats. Identities = 66/312 (21%), Positives = 108/312 (34%), Gaps = 57/312 (18%) Query: 14 ECVAEIGEGAYGKVFKARDLKNGGRF---VALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 E +G+G + +V+KA+ +N VA+K + S E + + Sbjct: 12 ELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEY-----ASWKTEKDIFSDIN- 65 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130 +H N+++ + + H +L YL + E ++ + L Sbjct: 66 LKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYL---TRHVISWEDLRKLGSSLA 122 Query: 131 RGLDFLHS---------HRVVHRDLKPQNILVTSSGQIKLADFGLA-----RIYSFQMAL 176 RG+ LHS +VHRDLK NILV + L DFGL+ + +A Sbjct: 123 RGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLAN 182 Query: 177 TSVVVTLWYRAPEV------LLQSSYATPVDLWSVGCIFAEMFRR----------KPLFR 220 + V T Y APEV L D++S+ + EM R +P F Sbjct: 183 SGQVGTARYMAPEVLASAMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFG 242 Query: 221 GSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKC 280 V P +V S + + + E L +C Sbjct: 243 S-----------KVREHPCVASMADNVLADAGRPEIPSFWLNHQGIQMVCET----LTEC 287 Query: 281 LTFNPAKRISAY 292 +P R++A Sbjct: 288 WDHDPEARLTAQ 299 >4BTK-A nrPDB Length = 337 Score = 150 bits (378), Expect = 1e-36, Method: Composition-based stats. Identities = 55/234 (23%), Positives = 100/234 (42%), Gaps = 23/234 (9%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 +++ + +IG G +G++++A DL VALK Q ++ + + EVAVL+ L+ Sbjct: 56 DRWKVLKKIGGGGFGEIYEAMDLLT-RENVALKVESAQQPKQVLKM----EVAVLKKLQG 110 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130 +H V R + + +V + ++L P T + Q+L Sbjct: 111 KDH--VCRFIGCGRNEKFN-----YVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQIL 163 Query: 131 RGLDFLHSHRVVHRDLKPQNI----LVTSSGQIKLADFGLARIYS-------FQMALTSV 179 ++ +HS +HRD+KP N L ++ + + DFGLAR Y+ + Sbjct: 164 ESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGF 223 Query: 180 VVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILD 233 T+ Y + DLWS+ + E + +R D +Q+G I + Sbjct: 224 RGTVRYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKE 277 >2Y4I-B nrPDB Length = 319 Score = 150 bits (378), Expect = 1e-36, Method: Composition-based stats. Identities = 58/308 (18%), Positives = 117/308 (37%), Gaps = 40/308 (12%) Query: 6 LCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVL 65 +Q E IG+G +G+V+ R VA++ + ++ E + REV Sbjct: 28 WDIPFEQLEIGELIGKGRFGQVYHGRWHG----EVAIRLIDIERDNEDQLKAFKREVMAY 83 Query: 66 RHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDM 125 R H NVV C L ++ + + + + + + Sbjct: 84 RQ---TRHENVVLFMGACM-----SPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQI 135 Query: 126 MFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSF------QMALTSV 179 ++++G+ +LH+ ++H+DLK +N+ +G++ + DFGL I + L Sbjct: 136 AQEIVKGMGYLHAKGILHKDLKSKNVFYD-NGKVVITDFGLFSISGVLQAGRREDKLRIQ 194 Query: 180 VVTLWYRAPEVLLQ---------SSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGK 230 L + APE++ Q ++ D++++G I+ E+ R+ F+ Sbjct: 195 NGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFK----TQPAEA 250 Query: 231 ILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRIS 290 I+ +G + + + + E+ D+L K N +R+S Sbjct: 251 IIWQMGTGMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLEKLPKRN--RRLS 308 Query: 291 AYSALSHP 298 HP Sbjct: 309 ------HP 310 >4NFN-A nrPDB Length = 309 Score = 149 bits (376), Expect = 2e-36, Method: Composition-based stats. Identities = 55/234 (23%), Positives = 100/234 (42%), Gaps = 23/234 (9%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 +++ + +IG G +G++++A DL VALK Q ++ + + EVAVL+ L+ Sbjct: 21 DRWKVLKKIGGGGFGEIYEAMDLLT-RENVALKVESAQQPKQVLKM----EVAVLKKLQG 75 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130 +H V R + + +V + ++L P T + Q+L Sbjct: 76 KDH--VCRFIGCGRNEKFN-----YVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQIL 128 Query: 131 RGLDFLHSHRVVHRDLKPQNI----LVTSSGQIKLADFGLARIYS-------FQMALTSV 179 ++ +HS +HRD+KP N L ++ + + DFGLAR Y+ + Sbjct: 129 ESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGF 188 Query: 180 VVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILD 233 T+ Y + DLWS+ + E + +R D +Q+G I + Sbjct: 189 RGTVRYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKE 242 >4M66-A nrPDB Length = 325 Score = 148 bits (375), Expect = 2e-36, Method: Composition-based stats. Identities = 65/297 (21%), Positives = 111/297 (37%), Gaps = 41/297 (13%) Query: 9 ADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHL 68 + ++ + + +G+G +G VF+A + VA+K V + EV + +L Sbjct: 18 SREELKKLEFVGKGGFGVVFRA-HHRTWNHDVAVKIVNSK--------KISWEVKAMVNL 68 Query: 69 ETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQ 128 + NV+ L V + D + LV ++ L + PE P + ++ + Sbjct: 69 R---NENVLLLLGVTEDLQWDFVSGQALVTRFMENGSLAGLLQ-PEAPRPWPLLCRLLQE 124 Query: 129 LLRGLDFLHSHR--VVHRDLKPQNILVTSSGQIKLADFGLARIY-------SFQMALTSV 179 ++ G+ +LHS ++HRDLKP NIL+ KLADFGL+ Sbjct: 125 VVLGMCYLHSLDPPLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQSGSGSGSGSRDS 184 Query: 180 VVTLWYRAPEVLL--QSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGL 237 TL Y PE+L + D++S G + + L Sbjct: 185 GGTLAYLDPELLFKVNLKASKASDVYSFGILVWAVLAG-----------------REAEL 227 Query: 238 PGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSA 294 + R+ RQ+ + P T E K+L++ C R S Sbjct: 228 VDKTSLIRETVCDRQSRPPLTELPPGSPETPGLEKLKELMIHCWGSQSENRPSFQDC 284 >2QLU-A nrPDB Length = 314 Score = 148 bits (375), Expect = 2e-36, Method: Composition-based stats. Identities = 64/291 (21%), Positives = 108/291 (37%), Gaps = 37/291 (12%) Query: 21 EGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLF 80 G +G V+KA+ + + FVA+K +Q + I ++ H N+++ Sbjct: 25 RGRFGCVWKAQLMND---FVAVKIFPLQDKQSWQSEREIFSTPGMK------HENLLQFI 75 Query: 81 DVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHS- 138 ++ E +L L+ D LT YL + + + + RGL +LH Sbjct: 76 AA-EKRGSNLEVELWLITAFHDKGSLTDYLK---GNIITWNELCHVAETMSRGLSYLHED 131 Query: 139 ----------HRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMA---LTSVVVTLWY 185 + HRD K +N+L+ S LADFGLA + V T Y Sbjct: 132 VPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVGTRRY 191 Query: 186 RAPEVL-----LQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGE 240 APEVL Q +D++++G + E+ R G D L ++ P Sbjct: 192 MAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSL 251 Query: 241 EDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISA 291 E+ V + K + + + +C + R+SA Sbjct: 252 EELQEVVVHKKMRPTIKDHWLKHPGLAQLCVT----IEECWDHDAEARLSA 298 >4M69-B nrPDB Length = 283 Score = 148 bits (375), Expect = 3e-36, Method: Composition-based stats. Identities = 53/282 (18%), Positives = 112/282 (39%), Gaps = 44/282 (15%) Query: 25 GKVFKARDLKNGGRFVALKRVRVQTGEEG--MPLSTIREVAVLRHLETFEHPNVVRLFDV 82 +++ ++ V +K E + + E+ ++ F+ PN++R+F + Sbjct: 23 STIYRGEYHRS---PVTIKVFNNPQAESVGIVRFTFNDEIKTMKK---FDSPNILRIFGI 76 Query: 83 CTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRV 141 C + +T + + ++V E+ + L LD+ + + ++ ++ + RGL LH Sbjct: 77 C-IDQTVKPPEFSIVMEYCELGTLRELLDREKDLTMSVRSL--LVLRAARGLYRLHHSET 133 Query: 142 VHRDLKPQNILVTSSGQIKLADFGLARIYSF-----QMALTSVVVTLWYRAPEVLLQ--S 194 +HR++ + LV Q+KLA F L++ + + + Y +PE L Sbjct: 134 LHRNISSSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFC 193 Query: 195 SYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAF 254 Y +++S G + E+ K F G KI +++ Sbjct: 194 LYDIKAEIYSFGIVLWEIATGKIPFEGCDS----KKIRELVA------------------ 231 Query: 255 HSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALS 296 + E D EL ++++ +C P++R S L Sbjct: 232 ---EDKKQEPVGQDCPELLREIINECRAHEPSQRPSVDGILE 270 >4BTF-A nrPDB Length = 469 Score = 148 bits (373), Expect = 4e-36, Method: Composition-based stats. Identities = 53/282 (18%), Positives = 112/282 (39%), Gaps = 44/282 (15%) Query: 25 GKVFKARDLKNGGRFVALKRVRVQTGEEG--MPLSTIREVAVLRHLETFEHPNVVRLFDV 82 +++ ++ V +K E + + E+ ++ F+ PN++R+F + Sbjct: 209 STIYRGEYHRS---PVTIKVFNNPQAESVGIVRFTFNDEIKTMKK---FDSPNILRIFGI 262 Query: 83 CTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRV 141 C + +T + + ++V E+ + L LD+ + + ++ ++ + RGL LH Sbjct: 263 C-IDQTVKPPEFSIVMEYCELGTLRELLDREKDLTMSVRSL--LVLRAARGLYRLHHSET 319 Query: 142 VHRDLKPQNILVTSSGQIKLADFGLARIYSF-----QMALTSVVVTLWYRAPEVLLQ--S 194 +HR++ + LV Q+KLA F L++ + + + Y +PE L Sbjct: 320 LHRNISSSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFC 379 Query: 195 SYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAF 254 Y +++S G + E+ K F G KI +++ Sbjct: 380 LYDIKAEIYSFGIVLWEIATGKIPFEGCDS----KKIRELVA------------------ 417 Query: 255 HSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALS 296 + E D EL ++++ +C P++R S L Sbjct: 418 ---EDKKQEPVGQDCPELLREIINECRAHEPSQRPSVDGILE 456 >4MWI-A nrPDB Length = 294 Score = 147 bits (372), Expect = 6e-36, Method: Composition-based stats. Identities = 54/281 (19%), Positives = 107/281 (38%), Gaps = 46/281 (16%) Query: 28 FKARDLKNGGRFVALKRVRVQTGEEG--MPLSTIREVAVLRHLETFEHPNVVRLFDVCTV 85 +K + VA+K + + + +E+ ++ FE PN++R+F +C + Sbjct: 41 YKGEYHRA---PVAIKVFKKLQAGSIAIVRQTFNKEIKTMKK---FESPNILRIFGIC-I 93 Query: 86 SRTDRETKLTLVFEHVD-QDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRV--V 142 T + ++V E+ + L LD+ + + + ++ RGL LH + Sbjct: 94 DETVTPPQFSIVMEYCELGTLRELLDREKDLTLGKRMV--LVLGAARGLYRLHHSEAPEL 151 Query: 143 HRDLKPQNILVTSSGQIKLADFGL-----ARIYSFQMALTSVVVTLWYRAPEVLLQ--SS 195 H ++ N LVT Q+KLA F L + T V + Y +P+ L Sbjct: 152 HGKIRSSNFLVTQGYQVKLAGFELRKTQTSMSLGTTREKTDRVKSTAYLSPQELEDVFYQ 211 Query: 196 YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFH 255 Y +++S G + E+ F+G + KI ++ + ++ Sbjct: 212 YDVKSEIYSFGIVLWEIATGDIPFQGCNS----EKIRKLVAVKRQQ-------------- 253 Query: 256 SKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALS 296 E D ++++ +C +P+ R S L Sbjct: 254 -------EPLGEDCPSELREIIDECRAHDPSVRPSVDEILK 287 >6BFN-A nrPDB Length = 342 Score = 146 bits (369), Expect = 1e-35, Method: Composition-based stats. Identities = 55/228 (24%), Positives = 85/228 (37%), Gaps = 28/228 (12%) Query: 6 LCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEG--MPLSTIREVA 63 + R + +IGEG +G V++A A+KR++ E + S + EV Sbjct: 17 ISRGTHNFSEELKIGEGGFGCVYRAVMRNT---VYAVKRLKENADLEWTAVKQSFLTEVE 73 Query: 64 VLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTT---YLDKVPEPGVPTE 120 L F HPN+V C + LV+ + + P + Sbjct: 74 ---QLSRFRHPNIVDFAGYCA-----QNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWP 125 Query: 121 TIKDMMFQLLRGLDFLH--SHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQM---- 174 D++ R + FLH S ++H D+K N+L+ KL DFGLAR F Sbjct: 126 QRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPS 185 Query: 175 ------ALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRK 216 +V TL Y E + A D +S G + E + Sbjct: 186 QSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQ 233 >3HNG-A nrPDB Length = 360 Score = 141 bits (357), Expect = 3e-34, Method: Composition-based stats. Identities = 50/221 (22%), Positives = 87/221 (39%), Gaps = 37/221 (16%) Query: 81 DVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHR 140 + S + L+ V E D D + + E + FQ+ RG++FL S + Sbjct: 166 ESFASSGFQEDKSLSDVEEEEDSDGFY------KEPITMEDLISYSFQVARGMEFLSSRK 219 Query: 141 VVHRDLKPQNILVTSSGQIKLADFGLARIY---SFQMALTSVVVTLWYRAPEVLLQSSYA 197 +HRDL +NIL++ + +K+ DFGLAR + + L + APE + Y+ Sbjct: 220 CIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRKGDTRLPLKWMAPESIFDKIYS 279 Query: 198 TPVDLWSVGCIFAEMFR-RKPLFRGSS-DVDQLGKILDVIGLPGEEDWPRDVALPRQAFH 255 T D+WS G + E+F + G D D ++ + + + E + P Sbjct: 280 TKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGMRMRAPE-----YSTPE---- 330 Query: 256 SKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALS 296 I ++ D C +P +R + Sbjct: 331 -------------IYQIMLD----CWHRDPKERPRFAELVE 354 Score = 75.0 bits (183), Expect = 4e-14, Method: Composition-based stats. Identities = 28/126 (22%), Positives = 49/126 (38%), Gaps = 12/126 (9%) Query: 6 LCRADQQYECVAEIGEGAYGKVFKA----RDLKNGGRFVALKRVRVQTGEEGMPLSTIRE 61 A ++ + +G GA+GKV +A R VA+K ++ + + E Sbjct: 22 WEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATASEYK-ALMTE 80 Query: 62 VAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPGVPTE 120 + +L H+ H NVV L CT L ++ E+ +L+ YL + + Sbjct: 81 LKILTHIG--HHLNVVNLLGACTKQG----GPLMVIVEYCKYGNLSNYLKSKRDLFFLNK 134 Query: 121 TIKDMM 126 M Sbjct: 135 DAALHM 140 >3VHK-A nrPDB Length = 368 Score = 140 bits (354), Expect = 7e-34, Method: Composition-based stats. Identities = 40/192 (20%), Positives = 75/192 (39%), Gaps = 29/192 (15%) Query: 110 DKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARI 169 + + + + E + FQ+ +G++FL S + +HRDL +NIL++ +K+ DFGLAR Sbjct: 190 EDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARD 249 Query: 170 Y---SFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDV 225 + + L + APE + Y D+WS G + E+F + G Sbjct: 250 IYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKID 309 Query: 226 DQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNP 285 ++ + L D+ ++ + D C P Sbjct: 310 EEFCRRLKEGTRMRAPDY---------------------TTPEMYQTMLD----CWHGEP 344 Query: 286 AKRISAYSALSH 297 ++R + + H Sbjct: 345 SQRPTFSELVEH 356 Score = 78.0 bits (191), Expect = 6e-15, Method: Composition-based stats. Identities = 31/128 (24%), Positives = 50/128 (39%), Gaps = 12/128 (9%) Query: 6 LCRADQQYECVAEIGEGAYGKVFKA----RDLKNGGRFVALKRVRVQTGEEGMPLSTIRE 61 + + +G GA+G+V +A D R VA+K ++ + + E Sbjct: 24 WEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHR-ALMSE 82 Query: 62 VAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPGVPTE 120 + +L H+ H NVV L CT L ++ E +L+TYL VP + Sbjct: 83 LKILIHIG--HHLNVVNLLGACTKPG----GPLMVIVEFCKFGNLSTYLRSKRNEFVPYK 136 Query: 121 TIKDMMFQ 128 T Q Sbjct: 137 TKGARFRQ 144 >2PZI-A nrPDB Length = 681 Score = 138 bits (348), Expect = 3e-33, Method: Composition-based stats. Identities = 65/284 (22%), Positives = 109/284 (38%), Gaps = 49/284 (17%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALK-RVRVQTGEEGMPLSTIREVAVLRHLET 70 QYE I G G ++ A D GR V LK V E R + L Sbjct: 81 QYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAER-----QFLAE 135 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130 HP++V++F+ + + +V E+V L + +P + ++L Sbjct: 136 VVHPSIVQIFNFVEHTDRHGDPVGYIVMEYVGG---QSLKRSKGQKLPVAEAIAYLLEIL 192 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFG-LARIYSFQMALTSVVVTLWYRAPE 189 L +LHS +V+ DLKP+NI++T Q+KL D G ++RI SF T ++APE Sbjct: 193 PALSYLHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINSFGYLY----GTPGFQAPE 247 Query: 190 VLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVAL 249 ++ D+++VG A + + LP Sbjct: 248 IVRTGP-TVATDIYTVGRTLAAL---------------------TLDLPT---------- 275 Query: 250 PRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYS 293 R + + + D G+ LL + + +P +R + Sbjct: 276 -RNGRYVDGLPEDDPVLKTYDSYGR-LLRRAIDPDPRQRFTTAE 317 >4Y12-A nrPDB Length = 375 Score = 138 bits (348), Expect = 3e-33, Method: Composition-based stats. Identities = 65/284 (22%), Positives = 109/284 (38%), Gaps = 49/284 (17%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALK-RVRVQTGEEGMPLSTIREVAVLRHLET 70 QYE I G G ++ A D GR V LK V E R + L Sbjct: 120 QYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAER-----QFLAE 174 Query: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130 HP++V++F+ + + +V E+V L + +P + ++L Sbjct: 175 VVHPSIVQIFNFVEHTDRHGDPVGYIVMEYVGG---QSLKRSKGQKLPVAEAIAYLLEIL 231 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFG-LARIYSFQMALTSVVVTLWYRAPE 189 L +LHS +V+ DLKP+NI++T Q+KL D G ++RI SF T ++APE Sbjct: 232 PALSYLHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINSFGYLY----GTPGFQAPE 286 Query: 190 VLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVAL 249 ++ D+++VG A + + LP Sbjct: 287 IVRTGP-TVATDIYTVGRTLAAL---------------------TLDLPT---------- 314 Query: 250 PRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYS 293 R + + + D G+ LL + + +P +R + Sbjct: 315 -RNGRYVDGLPEDDPVLKTYDSYGR-LLRRAIDPDPRQRFTTAE 356 >3SV0-A nrPDB Length = 483 Score = 136 bits (344), Expect = 1e-32, Method: Composition-based stats. Identities = 58/287 (20%), Positives = 107/287 (37%), Gaps = 32/287 (11%) Query: 8 RADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRH 67 R ++ +IG G++G+++ +++ VA+K V+T + E + R Sbjct: 4 RVGNKFRLGRKIGSGSFGEIYLGTNIQTNEE-VAIKLENVKTKHP----QLLYESKIYRI 58 Query: 68 LETFEH-PNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMM 126 L+ PN VR F V LV + + L + + +T+ + Sbjct: 59 LQGGTGIPN-VRWFGV-------EGDYNVLVMDLLGPSLEDLFN-FCSRKLSLKTVLMLA 109 Query: 127 FQLLRGLDFLHSHRVVHRDLKPQNILVT---SSGQIKLADFGLARIYSF--------QMA 175 Q++ ++F+HS +HRD+KP N L+ + Q+ + DFGLA+ Y Sbjct: 110 DQMINRVEFVHSKSFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDTSTHQHIPYRE 169 Query: 176 LTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRG---SSDVDQLGKIL 232 ++ T Y + L + DL S+G + R ++G + + KI Sbjct: 170 NKNLTGTARYASVNTHLGIEQSRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKYEKIS 229 Query: 233 DVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDE---LGKDL 276 + E R ++ D L +DL Sbjct: 230 EKKVATSIEALCRGYPTEFASYFHYCRSLRFDDKPDYSYLKRLFRDL 276 >5VC6-A nrPDB Length = 289 Score = 133 bits (336), Expect = 8e-32, Method: Composition-based stats. Identities = 65/315 (20%), Positives = 120/315 (38%), Gaps = 67/315 (21%) Query: 8 RADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRH 67 R ++ + +IG G +G VFK +G A+KR + + +REV H Sbjct: 8 RYTTEFHELEKIGSGEFGSVFKCVKRLDGC-IYAIKRSKKPLAGSVDEQNALREV--YAH 64 Query: 68 LETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQD-LTTYLDKVPE--PGVPTETIKD 124 +H +VVR F + + + E+ + L + + +KD Sbjct: 65 AVLGQHSHVVRYFSAWA-----EDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKD 119 Query: 125 MMFQLLRGLDFLHSHRVVHRDLKPQNILVT-----------------SSGQI--KLADFG 165 ++ Q+ RGL ++HS +VH D+KP NI ++ +S ++ K+ D G Sbjct: 120 LLLQVGRGLRYIHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLG 179 Query: 166 -LARIYSFQMALTSVVVTLWYRAPEVLLQSSYAT--PVDLWSVGCIFAEMFRRKPLFRGS 222 + RI S Q+ + A EVL ++ Y D++++ +PL R Sbjct: 180 HVTRISSPQVEEGDS----RFLANEVLQEN-YTHLPKADIFALALTVVCAAGAEPLPR-- 232 Query: 223 SDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLT 282 + DQ +I + + + + +LL + Sbjct: 233 -NGDQWHEIRQG--------------------------RLPRIPQVLSQEFTELLKVMIH 265 Query: 283 FNPAKRISAYSALSH 297 +P +R SA + + H Sbjct: 266 PDPERRPSAMALVKH 280 >5L2Q-C nrPDB Length = 320 Score = 130 bits (327), Expect = 9e-31, Method: Composition-based stats. Identities = 58/301 (19%), Positives = 107/301 (35%), Gaps = 58/301 (19%) Query: 28 FKARDLKNGGRFVALKRVRVQT-GEEGMPLSTIREVAVLRH----LETFEH--PNVVRLF 80 AR F LK + ++ G++G+ R+ +L H L + H VV Sbjct: 33 CLAR-KDGTDDFYQLKILTLEERGDQGIESQEERQGKMLLHTEYSLLSLLHTQDGVVHHH 91 Query: 81 DVCTVSRTD-------------RETKLTLVFE-HVDQDLTTY------LDK--VPEPGVP 118 + + + ++ LV + D + L + E + Sbjct: 92 GLFQDRTCEIVEDTESSRMVKKMKKRICLVLDCLCAHDFSDKTADLINLQHYVIKEKRLS 151 Query: 119 TETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTS-SGQIKLADFGLAR-IYSFQMAL 176 + + ++R ++ LH +VHRDLK N+++ + +I + +F L + + S L Sbjct: 152 ERETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEGDLL 211 Query: 177 TSVVVTLWYRAPEVLLQSSY-ATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVI 235 + Y +P+VL Y P D+W++G + M + F S + KI Sbjct: 212 KDQRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPFYDSIPQELFRKI---- 267 Query: 236 GLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSAL 295 E P D + L+ K L +P +R++A L Sbjct: 268 -KAAEYTIPEDGRVSENTVC--------------------LIRKLLVLDPQQRLAAADVL 306 Query: 296 S 296 Sbjct: 307 E 307 >4JRN-A nrPDB Length = 372 Score = 129 bits (325), Expect = 1e-30, Method: Composition-based stats. Identities = 59/318 (18%), Positives = 108/318 (33%), Gaps = 66/318 (20%) Query: 18 EIGEGAYGKVFKARDLKNGGRFVALKR-VRVQTGEEGMPLSTIREVAVLRH--------- 67 +G G + V++A D++ A+K + + + L RE + R+ Sbjct: 75 PLGSGGFATVYEATDVETNEEL-AVKVFMSEKEPTDETMLDLQRESSCYRNFSLAKTAKD 133 Query: 68 ----LETFEHPNVVRLFD------VCTVSRTDRETKLTLVFEHVDQDLTTYLD------K 111 +VV L V T L+ + D++ + Sbjct: 134 AQESCRFMVPSDVVMLEGQPASTEVVIGLTTRWVPNYFLLMMRAEADMSKVISWVFGDAS 193 Query: 112 VPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYS 171 V + + Q ++ + + + +VH D+KP N L+ G++ L DFG RI + Sbjct: 194 VNKSEFGLVVRMYLSSQAIKLVANVQAQGIVHTDIKPANFLLLKDGRLFLGDFGTYRINN 253 Query: 172 FQMALTSVVVTLWYRAPEVLLQS---SYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQL 228 ++ + T Y PE Q+ +Y P D W +G ++ ++ D L Sbjct: 254 ---SVGRAIGTPGYEPPERPFQATGITYTFPTDAWQLGITLYCIWCKERPTPADGIWDYL 310 Query: 229 GKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKR 288 D P EL +DL+ L +P KR Sbjct: 311 ----------HFADCPS-----------------------TPELVQDLIRSLLNRDPQKR 337 Query: 289 ISAYSALSHPYFQDLERC 306 + AL F++++ Sbjct: 338 MLPLQALETAAFKEMDSV 355 >4RT7-A nrPDB Length = 415 Score = 128 bits (322), Expect = 4e-30, Method: Composition-based stats. Identities = 40/182 (21%), Positives = 70/182 (38%), Gaps = 29/182 (15%) Query: 117 VPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY---SFQ 173 + E + +Q+ +G++FL VHRDL +N+LVT +K+ DFGLAR S Sbjct: 240 LTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNY 299 Query: 174 MALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKIL 232 + + + + + APE L + Y D+WS G + E+F + G K++ Sbjct: 300 VVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLI 359 Query: 233 DVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAY 292 + + + ++ C F+ KR S Sbjct: 360 QNGFKMDQPFYATEEIYI-------------------------IMQSCWAFDSRKRPSFP 394 Query: 293 SA 294 + Sbjct: 395 NL 396 Score = 85.4 bits (210), Expect = 3e-17, Method: Composition-based stats. Identities = 30/115 (26%), Positives = 49/115 (42%), Gaps = 13/115 (11%) Query: 6 LCRADQQYECVAEIGEGAYGKVFKARDL---KNGGRF-VALKRVRVQTGEEGMPLSTIRE 61 + E +G GA+GKV A K G VA+K ++ + + + + E Sbjct: 60 WEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLK-EKADSSEREALMSE 118 Query: 62 VAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEH-VDQDLTTYLDKVPEP 115 + ++ L + H N+V L CT+S + L+FE+ DL YL E Sbjct: 119 LKMMTQLGS--HENIVNLLGACTLS-----GPIYLIFEYCCYGDLLNYLRSKREK 166 >5J0A-A nrPDB Length = 300 Score = 128 bits (321), Expect = 4e-30, Method: Composition-based stats. Identities = 52/296 (17%), Positives = 102/296 (34%), Gaps = 28/296 (9%) Query: 17 AEIGEGAYGKVFKARDLKNG--GRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHP 74 ++G G V+ + G A+K++ + + R + + L++ HP Sbjct: 15 QKLGFGTGVNVYLMKRSPRGLSHSPWAVKKINPICNDHYRSVYQKRLMDEAKILKSLHHP 74 Query: 75 NVVRLFDVCTVSRTDRETKLTLVFEHVD----QDLTTYLDKVPEPGVPTETIKDMMFQLL 130 N+V + L L E+ DL K + P I + + Sbjct: 75 NIVGYRAFTEA----NDGSLCLAMEYGGEKSLNDLIEERYKASQDPFPAAIILKVALNMA 130 Query: 131 RGLDFLH-SHRVVHRDLKPQNILVTSSG-QIKLADFGLARIYSFQMALTS----VVVTLW 184 RGL +LH +++H D+K N+++ IK+ D G++ M +T + T Sbjct: 131 RGLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMEVTDPEACYIGTEP 190 Query: 185 YRAPEVLLQSSY-ATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDW 243 ++ E + ++ D+++ G EM ++ D E D+ Sbjct: 191 WKPKEAVEENGVITDKADIFAFGLTLWEMMTLSIP-----HINLSNDDDDEDKTFDESDF 245 Query: 244 PRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAY---SALS 296 + + + + + +L C +P R SA AL Sbjct: 246 DDEAYYAALGTRPPIN---MEELDESYQKVIELFSVCTNEDPKDRPSAAHIVEALE 298 >4TN6-A nrPDB Length = 318 Score = 127 bits (320), Expect = 5e-30, Method: Composition-based stats. Identities = 49/292 (16%), Positives = 101/292 (34%), Gaps = 30/292 (10%) Query: 7 CRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLR 66 R +Y +IG G++G ++ D+ G VA+K V+T + + E + + Sbjct: 3 LRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEE-VAIKLECVKTKHPQLHI----ESKIYK 57 Query: 67 HLETFEHPNVVRLFDVCTVSRTDRETKL-TLVFEHVDQDLTTYLDKVPEPGVPTETIKDM 125 ++ + T+ E +V E + L + +T+ + Sbjct: 58 MMQGG--------VGIPTIRWCGAEGDYNVMVMELLGPSLEDLFN-FCSRKFSLKTVLLL 108 Query: 126 MFQLLRGLDFLHSHRVVHRDLKPQNILVT---SSGQIKLADFGLARIYSF--------QM 174 Q++ ++++HS +HRD+KP N L+ + + DFGLA+ Y Sbjct: 109 ADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYR 168 Query: 175 ALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRG---SSDVDQLGKI 231 ++ T Y + L + DL S+G + ++G ++ + +I Sbjct: 169 ENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERI 228 Query: 232 LDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTF 283 + E + + + D L + L Sbjct: 229 SEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYL-RQLFRNLFHR 279 >5CEK-A nrPDB Length = 263 Score = 127 bits (319), Expect = 7e-30, Method: Composition-based stats. Identities = 46/241 (19%), Positives = 84/241 (34%), Gaps = 39/241 (16%) Query: 68 LETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMF 127 ++ H N+ + +V ETK + FE D+ +Y+ + E + Sbjct: 55 IQLPSHSNITGIVEVIL-----GETKAYVFFEKDFGDMHSYVRSRKR--LREEEAARLFK 107 Query: 128 QLLRGLDFLHSHRVVHRDLKPQNILVT--SSGQIKLADFGLARIYS-FQMALTSVVVTLW 184 Q++ + H +V DLK + + + Q++L I AL+ Sbjct: 108 QIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPA 167 Query: 185 YRAPEVLLQSS-Y-ATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEED 242 Y +PE+L + Y D+WS+G + + + F S KI E Sbjct: 168 YVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPE-- 225 Query: 243 WPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQD 302 I + L+ L P++R++A L HP+F+ Sbjct: 226 -------------------------HISPKARCLIRSLLRREPSERLTAPEILLHPWFES 260 Query: 303 L 303 + Sbjct: 261 V 261 >6DC0-A nrPDB Length = 292 Score = 126 bits (318), Expect = 9e-30, Method: Composition-based stats. Identities = 46/241 (19%), Positives = 85/241 (35%), Gaps = 39/241 (16%) Query: 68 LETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMF 127 ++ H N+ + +V ETK + FE D+ +Y+ + E + Sbjct: 52 IQLPSHSNITGIVEVIL-----GETKAYVFFEKDFGDMHSYVRSRKR--LREEEAARLFK 104 Query: 128 QLLRGLDFLHSHRVVHRDLKPQNILVT--SSGQIKLADFGLARIYS-FQMALTSVVVTLW 184 Q++ + H +V DLK + + + Q++L I AL+ Sbjct: 105 QIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPA 164 Query: 185 YRAPEVLLQSS-YA-TPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEED 242 Y +PE+L + Y+ D+WS+G + + + F S KI E Sbjct: 165 YVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPE-- 222 Query: 243 WPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQD 302 I + L+ L P++R++A L HP+F+ Sbjct: 223 -------------------------HISPKARCLIRSLLRREPSERLTAPEILLHPWFES 257 Query: 303 L 303 + Sbjct: 258 V 258 >5VDK-A nrPDB Length = 297 Score = 126 bits (316), Expect = 2e-29, Method: Composition-based stats. Identities = 58/312 (18%), Positives = 107/312 (34%), Gaps = 67/312 (21%) Query: 8 RADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRH 67 R ++++ V +IG G +G V+K +G A+KR E S + EV H Sbjct: 12 RYEKEFLEVEKIGVGEFGTVYKCIKRLDGC-VYAIKRSMKTFTELSNENSALHEV--YAH 68 Query: 68 LETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQD-LTTYLDKVPEPG--VPTETIKD 124 HP+VVR + S + + + E+ + L + + + G +KD Sbjct: 69 AVLGHHPHVVRYY-----SSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKD 123 Query: 125 MMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQ-----------------------IKL 161 ++ Q+ GL+++H+ +VH D+KP NI + Q K+ Sbjct: 124 ILLQISLGLNYIHNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKI 183 Query: 162 ADFGLARIYSFQMALTSVVVTLWYRAPEVLLQS-SYATPVDLWSVGCIFAEMFRRKPLFR 220 D G A + + A E+L + + D++++G A + L Sbjct: 184 GDLGHATSINKPKVEEGDS---RFLANEILQEDYRHLPKADIFALGLTIAVAAGAESLPT 240 Query: 221 GSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKC 280 + + K ++ E LL Sbjct: 241 NGAAWHHIRK-----------------------------GNFPDVPQELSESFSSLLKNM 271 Query: 281 LTFNPAKRISAY 292 + + +R SA Sbjct: 272 IQPDAEQRPSAA 283 >5FQD-C nrPDB Length = 341 Score = 125 bits (313), Expect = 4e-29, Method: Composition-based stats. Identities = 46/237 (19%), Positives = 98/237 (41%), Gaps = 29/237 (12%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETF 71 +Y+ V +IG G++G ++ A ++ NG VA+K ++ + E + + L+ Sbjct: 20 KYKLVRKIGSGSFGDIYLAINITNGEE-VAVKL----ESQKARHPQLLYESKLYKILQGG 74 Query: 72 EH-PNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130 P++ R + + LV + + L + +T+ + Q++ Sbjct: 75 VGIPHI-RWYG-------QEKDYNVLVMDLLGPSLEDLFN-FCSRRFTMKTVLMLADQMI 125 Query: 131 RGLDFLHSHRVVHRDLKPQNILVT---SSGQIKLADFGLARIYSFQMAL--------TSV 179 ++++H+ +HRD+KP N L+ ++ L DFGLA+ Y ++ Sbjct: 126 SRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNL 185 Query: 180 VVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRG---SSDVDQLGKILD 233 T Y + L + D+ S+G + R ++G ++ + KI + Sbjct: 186 TGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISE 242 >5X18-A nrPDB Length = 295 Score = 121 bits (304), Expect = 4e-28, Method: Composition-based stats. Identities = 57/283 (20%), Positives = 106/283 (37%), Gaps = 29/283 (10%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETF 71 Y+ +IGEG++G +F+ ++ N G VA+K +T + E + L Sbjct: 8 HYKIGKKIGEGSFGVLFEGTNMIN-GVPVAIKFEPRKTEAPQLRD----EYKTYKILNGT 62 Query: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLR 131 PN+ LV + + L D +T+ + Q++ Sbjct: 63 --PNI-----PYAYYFGQEGLHNILVIDLLGPSLEDLFD-WCGRKFSVKTVVQVAVQMIT 114 Query: 132 GLDFLHSHRVVHRDLKPQNILVTSSGQ-----IKLADFGLARIYSFQM--------ALTS 178 ++ LH+H +++RD+KP N L+ GQ I L DFG+A+ Y S Sbjct: 115 LIEDLHAHDLIYRDIKPDNFLIGRPGQPDANNIHLIDFGMAKQYRDPKTKQHIPYREKKS 174 Query: 179 VVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRG---SSDVDQLGKILDVI 235 + T Y + L + D+ ++G +F R ++G ++ + KI + Sbjct: 175 LSGTARYMSINTHLGREQSRRDDMEALGHVFFYFLRGHLPWQGLKAPNNKQKYEKIGEKK 234 Query: 236 GLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLL 278 D + + + + + D + K LL Sbjct: 235 RSTNVYDLAQGLPVQFGRYLEIVRSLSFEECPDYEGYRKLLLS 277 >5M07-A nrPDB Length = 276 Score = 121 bits (303), Expect = 5e-28, Method: Composition-based stats. Identities = 48/212 (22%), Positives = 88/212 (41%), Gaps = 28/212 (13%) Query: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQ-TGEEGMPLSTIREVAVLRHLETF 71 Y V +G A G+V+ + G + ALK + ++ RE V L Sbjct: 32 YTVVRMLGASAMGEVYLVQHPGFPG-WQALKVLSPAMAADDEFRRRFQRETEVAARL--- 87 Query: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQLL 130 HP+++ + D R + + +L + ++VD D T ++ +P + ++ + Sbjct: 88 FHPHILEVHD-----RGEFDGQLWIAMDYVDGIDATQHMADRFPAVLPVGEVLAIVTAVA 142 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTS----SGQIKLADFGLARIYSFQMALTSVVVTLWYR 186 LD+ H ++HRD+ P N+++TS +I LADFG+A Y Sbjct: 143 GALDYAHQRGLLHRDVNPANVVLTSQSAGDQRILLADFGIASQ-------------PSYP 189 Query: 187 APEVLLQSSYATPVDLWSVGCIFAEMFRRKPL 218 APE+ + D +++ +F P Sbjct: 190 APELSAGADVDGRADQYALALTAIHLFAGAPP 221 >2CHL-A nrPDB Length = 351 Score = 120 bits (301), Expect = 9e-28, Method: Composition-based stats. Identities = 57/293 (19%), Positives = 111/293 (37%), Gaps = 31/293 (10%) Query: 5 GLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAV 64 G+ + +IG G +G++ ++L +VA+K +++ + L E Sbjct: 24 GVLMVGPNFRVGKKIGCGNFGELRLGKNLYTN-EYVAIKLEPMKSRAPQLHL----EYRF 78 Query: 65 LRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKD 124 + L + + V F C +V E + L D + + +T+ Sbjct: 79 YKQLGSGDGIPQVYYFGPCGKYNA-------MVLELLGPSLEDLFD-LCDRTFSLKTVLM 130 Query: 125 MMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQ-----IKLADFGLARIYSF------- 172 + QL+ ++++HS +++RD+KP+N L+ G I + DF LA+ Y Sbjct: 131 IAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHI 190 Query: 173 -QMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRG---SSDVDQL 228 S+ T Y + L + DL ++G +F R ++G + ++ Sbjct: 191 PYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERY 250 Query: 229 GKILDVIG-LPGEEDWPRDVALPRQAFHSKSAQPIEK-FVTDIDELGKDLLLK 279 KI D P E + + + EK + +L DL + Sbjct: 251 QKIGDTKRATPIEVLCENFPEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDR 303 >5OAT-A nrPDB Length = 411 Score = 117 bits (294), Expect = 6e-27, Method: Composition-based stats. Identities = 62/336 (18%), Positives = 109/336 (32%), Gaps = 85/336 (25%) Query: 11 QQYECVAEIGEGAYGKVFKAR----DLKNGGRFVALKRV---RVQTGEEGMPLSTIRE-- 61 I +G G V+ A+ + + ALK + +Q + + RE Sbjct: 11 NDLSLGKPIAKGTNGVVYSAKVKDDETDDNKYPFALKMMFNYDIQENSMEILKAMYRETV 70 Query: 62 ---------------VAVLRHLETFE-HPNVVRLFDVCT------------VSRTDRETK 93 + + + HPN+V +F V T R Sbjct: 71 PARMYYSNHDLNNWEIELANRRKHLPPHPNIVAIFSVFTDLYPAALPPRLHPEGEGRNMS 130 Query: 94 LTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILV 153 L L+ + D +L ++L P + ++ G+ + +H + HRDLK N+L+ Sbjct: 131 LFLLMKRYDCNLQSFLSTAPSTRTSLLLLAQLL----EGVAHMTAHGIAHRDLKSDNLLL 186 Query: 154 TSSGQ----IKLADFGLA---RIYSFQMALTSVV----VTLWYRAPEVLLQSSYAT---- 198 +S + ++DFG + + TS APE++ Q Sbjct: 187 DTSEPESPILVISDFGCCLADKTNGLSLPYTSYEMDKGGNTALMAPEIICQKPGTFSVLN 246 Query: 199 --PVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHS 256 DLW+VG I E+F F G S + + Sbjct: 247 YSKADLWAVGAIAYEIFNCHNPFYGPSRLKNF---------------------------N 279 Query: 257 KSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAY 292 + K ++ + + L+ L NP KR+ Sbjct: 280 YKEGDLPKLPDEVPTVIQALVANLLKRNPNKRLDPE 315 >2C47-A nrPDB Length = 313 Score = 116 bits (290), Expect = 2e-26, Method: Composition-based stats. Identities = 59/288 (20%), Positives = 114/288 (39%), Gaps = 34/288 (11%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETF 71 + +IG G +G++ ++L +VA+K +++ + L E + L Sbjct: 5 NFRVGKKIGCGNFGELRLGKNLYTN-EYVAIKLEPIKSRAPQLHL----EYRFYKQLSAT 59 Query: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLR 131 E V F C +V E + L D + + +T+ + QL+ Sbjct: 60 EGVPQVYYFGPCGKYNA-------MVLELLGPSLEDLFD-LCDRTFTLKTVLMIAIQLIT 111 Query: 132 GLDFLHSHRVVHRDLKPQNILVTSSGQ-----IKLADFGLARIYSF--------QMALTS 178 ++++H+ +++RD+KP+N LV G I + DFGLA+ Y S Sbjct: 112 RMEYVHTKSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKS 171 Query: 179 VVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRG---SSDVDQLGKILDVI 235 + T Y + L + DL ++G +F R ++G + ++ KI D Sbjct: 172 LTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTK 231 Query: 236 G-LPGE---EDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLK 279 P E E++P ++A + + + + +L DL + Sbjct: 232 RATPIEVLCENFPEEMATYLRYV-RRLDFFEKPDYDYLRKLFTDLFDR 278 >4NT4-A nrPDB Length = 312 Score = 115 bits (287), Expect = 4e-26, Method: Composition-based stats. Identities = 55/298 (18%), Positives = 108/298 (36%), Gaps = 28/298 (9%) Query: 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR 60 M+ + + +IG G +G++ ++L N VA+K +++ + L R Sbjct: 2 MDPMAVLMVGPNFRVGKKIGCGNFGELRLGKNLYNN-EHVAIKMEPMKSKAPQLHLEY-R 59 Query: 61 EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTE 120 +L + R++ + T +V E + L + + + Sbjct: 60 FYKLLGSHADNAPDGIPRIYHLGTCGGRYN----AMVLELLGLSLEDLFN-ICARKFSLK 114 Query: 121 TIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQ-----IKLADFGLARIYSF--- 172 T+ + QLL ++++HS +++RD+KP+N L+ + I + DFGLA+ Y Sbjct: 115 TVLMIAKQLLHRIEYVHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDT 174 Query: 173 -----QMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRG---SSD 224 S+ T Y + + + DL ++G +F R ++G + Sbjct: 175 NRHIPYREHKSLTGTARYMSINTHMGREQSRRDDLEALGHMFMYFLRGSLPWQGLKADTL 234 Query: 225 VDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLT 282 ++ KI D E P + F D D L + Sbjct: 235 KERYQKIGDTKRATPIEVLCD--GHPEEFATYLRYVRRLDFFETPDY---DFLRRLFQ 287 >2CMW-A nrPDB Length = 310 Score = 112 bits (280), Expect = 2e-25, Method: Composition-based stats. Identities = 59/286 (20%), Positives = 112/286 (39%), Gaps = 33/286 (11%) Query: 14 ECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEH 73 +IG G +G++ ++L +VA+K +++ + L E + L + Sbjct: 3 RVGKKIGCGNFGELRLGKNLYTN-EYVAIKLEPIKSRAPQLHL----EYRFYKQLGSAGE 57 Query: 74 PNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGL 133 L V + +V E + L D + + +T+ + QLL + Sbjct: 58 ----GLPQVYYFGPCGKYN--AMVLELLGPSLEDLFD-LCDRTFTLKTVLMIAIQLLSRM 110 Query: 134 DFLHSHRVVHRDLKPQNILVTSSGQ-----IKLADFGLARIYSF--------QMALTSVV 180 +++HS +++RD+KP+N L+ G I + DFGLA+ Y S+ Sbjct: 111 EYVHSKNLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSLT 170 Query: 181 VTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRG---SSDVDQLGKILDVIG- 236 T Y + L + DL ++G +F R ++G + ++ KI D Sbjct: 171 GTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRN 230 Query: 237 LPGE---EDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLK 279 P E E++P ++A + + + + L DL K Sbjct: 231 TPIEALCENFPEEMATYLRYV-RRLDFFEKPDYEYLRTLFTDLFEK 275 >5X1R-A nrPDB Length = 302 Score = 110 bits (276), Expect = 6e-25, Method: Composition-based stats. Identities = 49/288 (17%), Positives = 95/288 (32%), Gaps = 32/288 (11%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKR----------------VRVQTGEEGM 54 ++E IGEG +G V++A D + R +A+K +R + + Sbjct: 21 NEFEIQEAIGEGGFGIVYRAYDHQL-ERTIAIKEYMPTSLAKRNDDLSIGLRGERFGKTF 79 Query: 55 PLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPE 114 + R L F HP ++ + + + + L Sbjct: 80 QAGLNSFIQEARLLARFSHPGLLHVLRFW-----EENGTAYMGTQFYSGTTLKNLQAQQP 134 Query: 115 PGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLAR-IYSFQ 173 + I+ ++ L ++ +H +HRD+ NI + S L DFG AR Sbjct: 135 EKIDEAWIRRLLPPLFSAINTIHQEGYLHRDISLDNIQIQESQLPVLLDFGSARKEIGNL 194 Query: 174 MALTSVVVTLWYRAPEVLLQSSYATP---VDLWSVGCIFAEMFRRKPLFRGSSDVDQLGK 230 T +V+ + E ++S D++++G + + P V + Sbjct: 195 SDETEIVLKPGFAPIEQYTENSDGEQGPWTDIYALGAVLHTLIVGSPP-----PVSVVRS 249 Query: 231 ILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLL 278 I D P E P + ++ + + +LL Sbjct: 250 IEDSYQ-PLTERRPAGYSPELLRTVDRALALKPEDRPQTIDEMAELLE 296 >4XHH-A nrPDB Length = 403 Score = 110 bits (276), Expect = 7e-25, Method: Composition-based stats. Identities = 46/283 (16%), Positives = 103/283 (36%), Gaps = 29/283 (10%) Query: 7 CRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLR 66 R +++ +IG G++G ++ +L +G VA++ +++ + E V + Sbjct: 3 LRVGRKFRIGRKIGSGSFGDIYHGTNLISGEE-VAIRLESIRSRHPQLD----YESRVYK 57 Query: 67 HLETFEHPNVVRLFDVCTVSRTDRETKL-TLVFEHVDQDLTTYLDKVPEPGVPTETIKDM 125 +L + + RE + +V + + L + +T+ + Sbjct: 58 YLSGG--------VGIPFIRWFGREGEYNAMVIDLLGPSLEDLFN-YCHRKFSFKTVIML 108 Query: 126 MFQLLRGLDFLHSHRVVHRDLKPQNILVT---SSGQIKLADFGLARIYSF--------QM 174 Q++ + ++H +HRD+KP N L+ + + DFGL++ Y Sbjct: 109 ALQMICRVQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYR 168 Query: 175 ALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRG---SSDVDQLGKI 231 S+ T Y + L + DL S+G + + ++G ++ + +I Sbjct: 169 ENKSLTGTARYASVNTHLGIEQSRRDDLESLGYMLIYFCKGSLPWQGLKATTKKQKYDRI 228 Query: 232 LDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGK 274 L+ E + L + + D L + Sbjct: 229 LEKKLCISVETLCAGLPLEFSEYMNYCRNLKFDERPDYLYLAR 271 >4L00-A nrPDB Length = 304 Score = 110 bits (275), Expect = 8e-25, Method: Composition-based stats. Identities = 53/316 (16%), Positives = 108/316 (34%), Gaps = 64/316 (20%) Query: 16 VAEIGEGA-----YGKVFKARDLKNGGRFVALKRVRV--QTGEEGMPLSTIREVAVLRHL 68 +G G G + +D + +K + + L+ +++R + Sbjct: 30 GEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQV 89 Query: 69 ETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQ 128 H ++V L+ VC + +V E V+ + T + Q Sbjct: 90 S---HKHIVYLYGVCVRDVEN-----IMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQ 141 Query: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQ-------IKLADFGLARIYSFQMALTSVVV 181 L L +L +VH ++ +N+L+ G IKL+D G+ + + Sbjct: 142 LASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIP 201 Query: 182 TLWYRAPEVLLQSS-YATPVDLWSVGCIFAEM-FRRKPLFRGSSDVDQLGKILDVIGLPG 239 + APE + S + D WS G E+ + + + + ++ Sbjct: 202 ---WIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIE------------- 245 Query: 240 EEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPY 299 ++ F+ +P EL DL+ +C+ ++P +R P+ Sbjct: 246 -----------KERFYESRCRP---VTPSCKELA-DLMTRCMNYDPNQR---------PF 281 Query: 300 FQDLERCKENLDSHLP 315 F+ + R L+ P Sbjct: 282 FRAIMRDINKLEEQNP 297 >3REP-A nrPDB Length = 271 Score = 110 bits (274), Expect = 1e-24, Method: Composition-based stats. Identities = 49/270 (18%), Positives = 91/270 (33%), Gaps = 42/270 (15%) Query: 25 GKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCT 84 G+++K R G + +K ++V+ E L F HPNV+ + C Sbjct: 24 GELWKGRW---QGNDIVVKVLKVRDWSTRKSRDFNEECP---RLRIFSHPNVLPVLGACQ 77 Query: 85 VSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHR-VVH 143 T +T + L L + V + RG+ FLH+ ++ Sbjct: 78 SPPAPHPTLITHWMPY--GSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFLHTLEPLIP 135 Query: 144 R-DLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYAT---P 199 R L +++++ +++ +A + F + + APE L + T Sbjct: 136 RHALNSRSVMIDEDMTARIS---MADV-KFSFQSPGRMYAPAWVAPEALQKKPEDTNRRS 191 Query: 200 VDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSA 259 D+WS + E+ R+ F S+++ K+ P Sbjct: 192 ADMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPT-------------------- 231 Query: 260 QPIEKFVTDIDELGKDLLLKCLTFNPAKRI 289 I L+ C+ +PAKR Sbjct: 232 -----IPPGISPHVSKLMKICMNEDPAKRP 256 >4XHL-A nrPDB Length = 394 Score = 109 bits (273), Expect = 1e-24, Method: Composition-based stats. Identities = 50/288 (17%), Positives = 106/288 (36%), Gaps = 32/288 (11%) Query: 7 CRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLR 66 R +++ +IG G++G ++ +L +G VA++ +++ + E V R Sbjct: 3 LRVGRKFRIGRKIGSGSFGDIYHGTNLISGEE-VAIRLESIRSRHPQLD----YESRVYR 57 Query: 67 HLETFEHPNVVRLFDVCTVSRTDRETKL-TLVFEHVDQDLTTYLDKVPEPGVPTETIKDM 125 +L + + RE + +V + + L + +T+ + Sbjct: 58 YLSGG--------VGIPFIRWFGREGEYNAMVIDLLGPSLEDLFN-YCHRRFSFKTVIML 108 Query: 126 MFQLLRGLDFLHSHRVVHRDLKPQNILVT---SSGQIKLADFGLARIYSF--------QM 174 Q+ + ++H +HRD+KP N L+ + + DFGL++ Y Sbjct: 109 ALQMFCRIQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYR 168 Query: 175 ALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRG---SSDVDQLGKI 231 S+ T Y + L + DL S+G + + ++G ++ + +I Sbjct: 169 ENKSLTGTARYASVNTHLGIEQSRRDDLESLGYVLIYFCKGSLPWQGLKATTKKQKYDRI 228 Query: 232 LDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTD---IDELGKDL 276 ++ E + L Q + + D + L KDL Sbjct: 229 MEKKLNVSVETLCSGLPLEFQEYMAYCKNLKFDEKPDYLFLARLFKDL 276 >5UV4-A nrPDB Length = 311 Score = 107 bits (268), Expect = 6e-24, Method: Composition-based stats. Identities = 56/277 (20%), Positives = 102/277 (36%), Gaps = 32/277 (11%) Query: 17 AEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNV 76 IG +G +KA + G + +K ++ + RE+ + L + HPN+ Sbjct: 31 EIIGRSCHGTSYKATL--DNGYMLTVKWLKEGFAKS--KKEFSREI---KKLGSVRHPNL 83 Query: 77 VRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPGVPTETI---KDMMFQLLRG 132 V L + ++ ++ D L+TYL + E +P + ++ + R Sbjct: 84 VPLRGYYWGPKEHER---IMISDYADATSLSTYLSEFDERNLPPLSAGQRLNIAIDIARC 140 Query: 133 LDFLHSHRVV-HRDLKPQNILV-TSSGQIKLADFGLARIYSFQMALTSV--VVTLWYRAP 188 LD+LH+ RV+ H ++K N+L+ S+ + D+ L R+ + V L Y P Sbjct: 141 LDYLHNERVIPHGNIKSSNVLIQNSTPSALVTDYSLHRLMTPIGMAEQVLNAGALGYSPP 200 Query: 189 EVLLQSSY--ATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRD 246 E S + D+++ G I E+ K I G+ DW R Sbjct: 201 EFSSTSKPCPSLKSDVYAFGVILLELLTGKI---------AGEIICMNDGVVDLTDWVRM 251 Query: 247 VALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTF 283 + L + ++ D L Sbjct: 252 LDLEERVSECYDRHITGVESSEGAPQALD---GMLRI 285 >1CSN-A nrPDB Length = 298 Score = 106 bits (265), Expect = 1e-23, Method: Composition-based stats. Identities = 55/288 (19%), Positives = 100/288 (34%), Gaps = 30/288 (10%) Query: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETF 71 Y+ IGEG++G +F+ +L N + VA+K + + R +L Sbjct: 11 HYKVGRRIGEGSFGVIFEGTNLLNNQQ-VAIK-FEPRRSDAPQLRDEYRTYKLLAGCTGI 68 Query: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLR 131 PN V F LV + + L LD + +T+ Q+L Sbjct: 69 --PN-VYYFG-------QEGLHNVLVIDLLGPSLEDLLD-LCGRKFSVKTVAMAAKQMLA 117 Query: 132 GLDFLHSHRVVHRDLKPQNILVTSSGQ-----IKLADFGLARIYSF--------QMALTS 178 + +H +V+RD+KP N L+ I + DFG+ + Y + Sbjct: 118 RVQSIHEKSLVYRDIKPDNFLIGRPNSKNANMIYVVDFGMVKFYRDPVTKQHIPYREKKN 177 Query: 179 VVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRG---SSDVDQLGKILDVI 235 + T Y + L + DL ++G +F R ++G +++ + +I + Sbjct: 178 LSGTARYMSINTHLGREQSRRDDLEALGHVFMYFLRGSLPWQGLKAATNKQKYERIGEKK 237 Query: 236 GLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTF 283 + + + D D L + L K L Sbjct: 238 QSTPLRELCAGFPEEFYKYMHYARNLAFDATPDYDYL-QGLFSKVLER 284 >4L68-A nrPDB Length = 340 Score = 103 bits (258), Expect = 8e-23, Method: Composition-based stats. Identities = 51/279 (18%), Positives = 93/279 (33%), Gaps = 35/279 (12%) Query: 25 GKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVA-VLRHLETFEHPNVVRLFDVC 83 G +KA L G +A+K + E RE + L H N+ L C Sbjct: 54 GTTYKA--LLPDGSALAVKHLSTCKLGE-------REFRYEMNQLWELRHSNLAPLLGFC 104 Query: 84 TVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHR--- 140 V LV++++ L + T + RGL +LH Sbjct: 105 VVEEEK-----FLVYKYMSNGTLHSLLDSNRGELDWSTRFRIGLGAARGLAWLHHGCRPP 159 Query: 141 VVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMA-----LTSVVVTLWYRAPEVLLQSS 195 ++H+++ IL+ ++ D GLAR+ +T + Y APE Sbjct: 160 ILHQNICSSVILIDEDFDARIIDSGLARLMVPSDNNESSFMTGDLGEFGYVAPEYSTTML 219 Query: 196 YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFH 255 + D++ +G + E+ L + DW + + + Sbjct: 220 ASLKGDVYGLGVVLLELATG------------LKAVGGEGFKGSLVDWVKQLESSGRIAE 267 Query: 256 SKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSA 294 + K + ++ L C++ P +R S + A Sbjct: 268 TFDENIRGKGHDEEISKFVEIALNCVSSRPKERWSMFQA 306 >6J6I-B nrPDB Length = 351 Score = 103 bits (258), Expect = 1e-22, Method: Composition-based stats. Identities = 48/248 (19%), Positives = 85/248 (34%), Gaps = 20/248 (8%) Query: 28 FKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREV--AVLRHLETFEHPNVVRLFDVCTV 85 +K + R +KR E ++EV ++ H N ++L C Sbjct: 72 YKWYRGEIEDRSYMIKRFSED--EITGKRHRVKEVYNDIVLSARMSNHSNFLQLLGCCL- 128 Query: 86 SRTDRETKLTLVFEHVDQDLTT----YLDKVPEPGVPTETIKDMMFQLLRGLDFLHS--- 138 LVFE + + E +P + ++ + +LH+ Sbjct: 129 ----EFPFPVLVFEFAEHGAMNQRGGVIVNGEESLLPWSVRLKIGKEIANAVTYLHTAFP 184 Query: 139 HRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTS---VVVTLWYRAPEVLLQSS 195 ++HRD+KP ++ + + KL+D + + V+ T Y P Sbjct: 185 KIIIHRDVKPMHVFLDKNWTAKLSDLSFSISLPEGKSRIEAEWVLGTFGYIDPLYHKTCF 244 Query: 196 YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFH 255 D++S G + KP SD D L IL ++ E +V PR Sbjct: 245 VTEYTDVYSFGICLLVIITGKPAIMTISDGD-LQGILSLVRELCENGKLDEVIDPRLMKD 303 Query: 256 SKSAQPIE 263 S Q ++ Sbjct: 304 ITSGQRLQ 311 >6EQI-C nrPDB Length = 433 Score = 101 bits (252), Expect = 5e-22, Method: Composition-based stats. Identities = 60/346 (17%), Positives = 106/346 (30%), Gaps = 93/346 (26%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGG----RFVALKRV---RVQTGEEGMPLSTIRE-V 62 + + I +G V+ A+ +A+K + V++ + + RE V Sbjct: 15 DELDLGEPIAKGCNAVVYSAKLKNVQSNKLAHQLAVKMMFNYDVESNSTAILKAMYRETV 74 Query: 63 AVLR----------------HLETFEHPNVVRLFDVCT---------------------- 84 + + HPN+VR++ V Sbjct: 75 PAMSYFFNQNLFNIENISDFKIRLPPHPNIVRMYSVFADRIPDLQCNKQLYPEALPPRIN 134 Query: 85 VSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHR 144 + R L LV + D L YL + + ++ QLL + ++ H + HR Sbjct: 135 PEGSGRNMSLFLVMKRYDCTLKEYLR---DKTPNMRSSILLLSQLLEAVAHMNIHNISHR 191 Query: 145 DLKPQNILVTSSG-----QIKLADFGLA-------RIYSFQMALTSVVVTLWYRAPEVLL 192 DLK NILV S I + DFG + ++ APE+ Sbjct: 192 DLKSDNILVDLSEGDAYPTIVITDFGCCLCDKQNGLVIPYRSEDQDKGGNRALMAPEIAN 251 Query: 193 QSSYA------TPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRD 246 DLW+VG I E+F F + Sbjct: 252 AKPGTFSWLNYKKSDLWAVGAIAYEIFNIDNPFYDKT----------------------- 288 Query: 247 VALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAY 292 + S + + + I + ++L+ L+ + KR+ Sbjct: 289 ---MKLLSKSYKEEDLPELPDTIPFIIRNLVSNMLSRSTNKRLDCD 331 >5USZ-A nrPDB Length = 289 Score = 96.1 bits (238), Expect = 2e-20, Method: Composition-based stats. Identities = 54/300 (18%), Positives = 96/300 (32%), Gaps = 59/300 (19%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNG------GRFVALKRVRVQTGEEGMPLSTIREVA 63 ++ +G+G + K+FK + G V LK + S + Sbjct: 7 NEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVL--DKAHRNYSESFFEAAS 64 Query: 64 VLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPGVPTETI 122 ++ L H ++V + VC + LV E V L TYL K + Sbjct: 65 MMSKLS---HKHLVLNYGVCVCGDEN-----ILVQEFVKFGSLDTYLKKNKNC-INILWK 115 Query: 123 KDMMFQLLRGLDFLHSHRVVHRDLKPQNILV--------TSSGQIKLADFGLARIYSFQM 174 ++ QL + FL + ++H ++ +NIL+ + IKL+D G++ + Sbjct: 116 LEVAKQLAAAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKD 175 Query: 175 ALTSVVVTLWYRAPEVLLQ-SSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKIL 232 L + + PE + + D WS G E+ +L Sbjct: 176 ILQERIP---WVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYE 232 Query: 233 DVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAY 292 D LP + +L+ C+ + P R S Sbjct: 233 DRHQLPAPK----------------------------AAELANLINNCMDYEPDHRPSFR 264 >4I94-A nrPDB Length = 300 Score = 94.2 bits (233), Expect = 7e-20, Method: Composition-based stats. Identities = 44/273 (16%), Positives = 87/273 (31%), Gaps = 42/273 (15%) Query: 26 KVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTV 85 V+K + R +A+KR ++ + + E + L N L C Sbjct: 44 VVYKGKL--ENQRRIAVKRFNRKSWPDS--RQFLEEAKAVGQLRNHRMAN---LLGCCY- 95 Query: 86 SRTDRETKLTLVFEHVDQD-LTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHR-VVH 143 + + L+ E + + L +L + + + + L++ S ++ Sbjct: 96 ----EDEERLLIAEFMPNETLAKHLFHWESQPMKWAMRLRVALHIAQALEYCTSKGRALY 151 Query: 144 RDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLW 203 DL +L +L+ FGL + + ++ L + PE L ++ Sbjct: 152 HDLNAYRVLFDDDANPRLSCFGLMKNSRDGKSYST---NLAFTPPEYLRTGRVTPESVIY 208 Query: 204 SVGCIFAEMFRRK--PLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQP 261 S G + ++ K P L I D R + Sbjct: 209 SFGTLLLDLLSGKHIPP------SHALDLIRD-----------------RNIQMLMDSGL 245 Query: 262 IEKFVTDIDELGKDLLLKCLTFNPAKRISAYSA 294 +F +D L +CL + P +R + S Sbjct: 246 EGQFSSDDGTELIRLASRCLQYEPRERPNPKSL 278 >4CYJ-A nrPDB Length = 438 Score = 92.3 bits (228), Expect = 3e-19, Method: Composition-based stats. Identities = 59/273 (21%), Positives = 107/273 (39%), Gaps = 42/273 (15%) Query: 27 VFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREV-AVLRHLETFEHPNVVRLFDVCTV 85 V+KA++ +N GR AL+R+ EG L+ + + V++ + ++ ++V + +V T Sbjct: 71 VYKAQNSRN-GRHYALRRL------EGYRLTNEKAILNVMKDWKKIKNASIVTIHEVFT- 122 Query: 86 SRTDRETKLTLVFEHVDQDLTTYLDK-----------VPEPGVPTETIKDMMFQLLRGLD 134 T +L+F + L+ L + P P VP TI + Q+ L Sbjct: 123 --TREFGDSSLIFAYDFHPLSKTLQEHHFQPIHGNRYRPPPAVPENTIWGYICQIANALK 180 Query: 135 FLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQS 194 +HS+R+ R L+P I++T +I+L+ + + F M SVV L Q Sbjct: 181 TIHSNRLAARCLEPSKIILTDINRIRLSACAILDVVQFGMNSRSVV---------ELQQE 231 Query: 195 SYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAF 254 + G + + + ++ + L+ +G + V Sbjct: 232 DFVK------FGKLILSLATGTLP----AHLNNIPAALETLGNKYSANLKSAVNWLLDT- 280 Query: 255 HSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAK 287 S + IE F+T I L N K Sbjct: 281 SSGETKTIEHFMTGIASQMTTFFDLALQDNDEK 313 >5C01-A nrPDB Length = 342 Score = 91.5 bits (226), Expect = 5e-19, Method: Composition-based stats. Identities = 56/310 (18%), Positives = 103/310 (33%), Gaps = 54/310 (17%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLE 69 ++ ++ +G+G V++ R G ++ + VL+ L+ Sbjct: 57 QKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLD 116 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKL-------------TLVFEHVDQDLTTYLDKVPEPG 116 H + ++ ++ T L +V E+V+ + Sbjct: 117 PSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGH 176 Query: 117 VPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQ-------IKLADFGLARI 169 VP + QL L +L + +VH ++ +NIL+ G IKL+D G+ Sbjct: 177 VPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLG 236 Query: 170 YSFQMALTSVVVTLWYRAPEVLLQS--SYATPVDLWSVGCIFAEM-FRRKPLFRGSSDVD 226 + + + APE L S +T +D W G E+ F + + S + Sbjct: 237 ALSREERVERIP---WLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSE 293 Query: 227 QLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPA 286 E + R LP +L L +CLT+ P Sbjct: 294 ------------KEHFYQRQHRLPE---------------PSCPQLAT-LTSQCLTYEPT 325 Query: 287 KRISAYSALS 296 +R S + L Sbjct: 326 QRPSFRTILR 335 >4WOV-A nrPDB Length = 317 Score = 90.7 bits (224), Expect = 7e-19, Method: Composition-based stats. Identities = 56/310 (18%), Positives = 103/310 (33%), Gaps = 54/310 (17%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLE 69 ++ ++ +G+G V++ R G ++ + VL+ L+ Sbjct: 34 QKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLD 93 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKL-------------TLVFEHVDQDLTTYLDKVPEPG 116 H + ++ ++ T L +V E+V+ + Sbjct: 94 PSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGH 153 Query: 117 VPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQ-------IKLADFGLARI 169 VP + QL L +L + +VH ++ +NIL+ G IKL+D G+ Sbjct: 154 VPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLG 213 Query: 170 YSFQMALTSVVVTLWYRAPEVLLQS--SYATPVDLWSVGCIFAEM-FRRKPLFRGSSDVD 226 + + + APE L S +T +D W G E+ F + + S + Sbjct: 214 ALSREERVERIP---WLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSE 270 Query: 227 QLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPA 286 E + R LP +L L +CLT+ P Sbjct: 271 ------------KEHFYQRQHRLPE---------------PSCPQLAT-LTSQCLTYEPT 302 Query: 287 KRISAYSALS 296 +R S + L Sbjct: 303 QRPSFRTILR 312 >5UU1-A nrPDB Length = 324 Score = 85.0 bits (209), Expect = 4e-17, Method: Composition-based stats. Identities = 36/232 (15%), Positives = 81/232 (34%), Gaps = 29/232 (12%) Query: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFV--ALKRV---------RVQTGEEGMPLSTI 59 Q+ +IG G +G ++ A + +K ++ + I Sbjct: 16 NQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDCI 75 Query: 60 REVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPT 119 ++ + L+ + LF ++ + +V E + DL Sbjct: 76 KKWIERKQLDYLG----IPLFYGSGLTEFKGRSYRFMVMERLGIDLQKI--SGQNGTFKK 129 Query: 120 ETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVT--SSGQIKLADFGLA---------R 168 T+ + ++L L+++H + VH D+K N+L+ + Q+ LAD+GL+ + Sbjct: 130 STVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNGNHK 189 Query: 169 IYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFR 220 Y T+ + + + + + D+ +G K + Sbjct: 190 QYQEN-PRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWE 240 >2RSV-A nrPDB Length = 403 Score = 80.3 bits (197), Expect = 1e-15, Method: Composition-based stats. Identities = 49/300 (16%), Positives = 110/300 (36%), Gaps = 27/300 (9%) Query: 8 RADQQYECVAEIGEGAYGKVFKARDLKNGGRF-----VALKRVRVQTGEEGMPLSTIREV 62 A ++++ IG+G +G ++ A D+ + +K G L + Sbjct: 39 MAKKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRA 97 Query: 63 AVLRHLETFEHPNVVRLFDV---CTVSRTDRETKLT--LVFEHVDQDLTTYLDKVPEPGV 117 A ++ + ++ V D+ K ++ + DL + + Sbjct: 98 AKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQK-IYEANAKRF 156 Query: 118 PTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVT--SSGQIKLADFGLARIYSFQMA 175 +T+ + ++L L+++H H VH D+K N+L+ + Q+ L D+GLA Y + Sbjct: 157 SRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGV 216 Query: 176 LTSVV--------VTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGS-SDVD 226 T+ + + + + + DL +G + + + D Sbjct: 217 HKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPK 276 Query: 227 QLG--KILDVIGLPGEED--WPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLT 282 + KI + D +P A + ++ + ++ + E +D+LL+ L Sbjct: 277 YVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDILLQGLK 336 >2LAV-A nrPDB Length = 361 Score = 79.2 bits (194), Expect = 2e-15, Method: Composition-based stats. Identities = 49/300 (16%), Positives = 110/300 (36%), Gaps = 27/300 (9%) Query: 8 RADQQYECVAEIGEGAYGKVFKARDLKNGGRF-----VALKRVRVQTGEEGMPLSTIREV 62 A ++++ IG+G +G ++ A D+ + +K G L + Sbjct: 32 MAKKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRA 90 Query: 63 AVLRHLETFEHPNVVRLFDV---CTVSRTDRETKLT--LVFEHVDQDLTTYLDKVPEPGV 117 A ++ + ++ V D+ K ++ + DL + + Sbjct: 91 AKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQK-IYEANAKRF 149 Query: 118 PTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVT--SSGQIKLADFGLARIYSFQMA 175 +T+ + ++L L+++H H VH D+K N+L+ + Q+ L D+GLA Y + Sbjct: 150 SRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGV 209 Query: 176 LTSVV--------VTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGS-SDVD 226 T+ + + + + + DL +G + + + D Sbjct: 210 HKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPK 269 Query: 227 QLG--KILDVIGLPGEED--WPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLT 282 + KI + D +P A + ++ + ++ + E +D+LL+ L Sbjct: 270 YVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDILLQGLK 329 >4IX6-A nrPDB Length = 350 Score = 78.4 bits (192), Expect = 4e-15, Method: Composition-based stats. Identities = 63/335 (18%), Positives = 99/335 (29%), Gaps = 73/335 (21%) Query: 18 EIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPN-- 75 +G G +G VF+ G + V LK + M + E + + H N Sbjct: 27 PLGSGNFGTVFRGVFK--GDQDVVLK----NAKADVMAAEELLECEM--DVNYHVHANAK 78 Query: 76 --VVRLFDVCTVSRTDRET--------KLTLVFEHVDQDLTTYLDKVPEPGVPTETI--- 122 R + D L L++ + ++ L + + T Sbjct: 79 GTCARFMGCIELGAKDGGEIYNGTLTEGLWLMWANEGENTVEALMRRGTAPLATAMACAD 138 Query: 123 -------KDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSS--GQIKLADFGLARI---Y 170 K M +LL L LH VVHRD+KP N++ G +KL D G A + Sbjct: 139 ATELGVTKKAMRELLGSLARLHECGVVHRDVKPANLIAAEKDGGVLKLIDLGAAALCLPL 198 Query: 171 SFQMALTSVVVT--LWY--------RAP--------------EVLLQSSYATPVDLWSVG 206 + Y P E + + WS G Sbjct: 199 PETLNYYPGDGPADPRYAKADELYLLPPGSPRPTKDNAAKLWEAHKPDRFDS----WSAG 254 Query: 207 CIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFV 266 C+ ++ G L + L + DV R + + Sbjct: 255 CVMLQLAV-----VGLRTDAGLERF-----LADYKAVGYDVNAFRGEKSGEYGTMDFAAL 304 Query: 267 TDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQ 301 G DL + + R S +ALSH +F Sbjct: 305 DANGGAGWDLCQRLMEAERDARASCEAALSHAFFD 339 >5CLR-A nrPDB Length = 451 Score = 78.0 bits (191), Expect = 5e-15, Method: Composition-based stats. Identities = 42/199 (21%), Positives = 71/199 (35%), Gaps = 26/199 (13%) Query: 28 FKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSR 87 FK L +G + LK V++ E L L RL + Sbjct: 96 FKVYALDDGKTYF-LKSVKIDAES---LTEFTNEKDTLSKLG--------RLVGTFFNEQ 143 Query: 88 TDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKD---MMFQLLRGLDFLHSHRVVHR 144 T ++ + + V + + +M + + H ++HR Sbjct: 144 TQVH---YILTTFIKGIDLSRYKNALPLNVNLKHFWEVLGIMISVCHQVKQFHELGLIHR 200 Query: 145 DLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSS---YATPVD 201 DLKP NI++ + Q L DFG + S + + T Y APE+ Q ++ D Sbjct: 201 DLKPGNIMLDADMQCHLVDFGSSS--SDKEPKPASWGTASYLAPELNAQEDFIAFSQVSD 258 Query: 202 LWSVGCIFAEMFRRKPLFR 220 L+++ E+F FR Sbjct: 259 LFALAYSLDELFN---PFR 274 >6EAS-A nrPDB Length = 308 Score = 76.1 bits (186), Expect = 2e-14, Method: Composition-based stats. Identities = 38/299 (12%), Positives = 89/299 (29%), Gaps = 39/299 (13%) Query: 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR 60 +++ L A + + + G+ + + G +A+ V + ++ + + Sbjct: 32 LKRSELETACEDFSNII----GSTSTCMLYKGTLSSGVEIAVASSLVTSAKDWSKENESQ 87 Query: 61 EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPGVPT 119 + +L H N + L C +VFE+ + L +L + Sbjct: 88 YRKKITNLSKVSHKNFMNLLGYCEEEHPFTR---VMVFEYAPNGTLFEHLHVREAEKLDW 144 Query: 120 ETIKDMMFQLLRGLDFLHSHRV--VHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALT 177 + + L+ +H + R+ + +T K++D + T Sbjct: 145 MARLRISMGIAYCLEHMHQLQTPAALRNFDSTTVYLTDDFAAKVSDLEFWNDAKGHNSTT 204 Query: 178 S--VVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVI 235 + + + E +++ G + E+ + SS+ D Sbjct: 205 NNELAFSPDM---EDIVRK----------YGMVLLEILTGRVP---SSEDD--------- 239 Query: 236 GLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSA 294 E+W I F D +++ C+ +P KR Sbjct: 240 --GPLENWVSRYFEGGMRLEELIDPSIGFFPEDTARALCEVVRSCIDRDPKKRPQMKEV 296 >4CI6-B nrPDB Length = 643 Score = 75.0 bits (183), Expect = 4e-14, Method: Composition-based stats. Identities = 49/297 (16%), Positives = 99/297 (33%), Gaps = 39/297 (13%) Query: 31 RDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHL--ETFEHPNVVRLFDVCTVSRT 88 + K+ R VA + E+ +H+ +HPN+ + + V Sbjct: 63 IETKDKQRLVA------KIERSIAEGHLFAELEAYKHIYKTAGKHPNLANVHGMAVVPYG 116 Query: 89 DRETKLTLVFEHVDQ-----DLTTYLDKVPEPGVPTE----TIKDMMFQLLRGLDFLHSH 139 +R L+ + VD L + D + + +E TIK + +LL + L Sbjct: 117 NRY-YYALLMDEVDGWRCSDTLRSLADSWKQGKINSEAYWGTIKFIAHRLLDVTNHLAKA 175 Query: 140 RVVHRDLKPQNILVT-SSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEV-LLQSSYA 197 +VH D+KP N++ +SG+ + D GL Q T ++APE+ + + Sbjct: 176 GIVHNDIKPGNVVFDRASGEPVVIDLGLHSRSGEQPKG----FTESFKAPELGVGNLGAS 231 Query: 198 TPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSK 257 D++ + + + F ++ + + P Sbjct: 232 EKSDVF---LVVSTLLHGIEGFEKDPEIK------------PNQGLRFITSEPAHVMDEN 276 Query: 258 SAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHL 314 + ++ + L + R + A H + D +E+ L Sbjct: 277 GYPIHRPGIAGVETAYTRFITDILGVSADSRPDSNEARLHEFLSDGTIDEESAKQIL 333 >2JII-A nrPDB Length = 352 Score = 73.8 bits (180), Expect = 9e-14, Method: Composition-based stats. Identities = 34/174 (19%), Positives = 65/174 (37%), Gaps = 12/174 (6%) Query: 83 CTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVV 142 C ++ LV + + L + LD P+ + ++ + +LL L+FLH + V Sbjct: 122 CMGFGVHQDKYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYV 181 Query: 143 HRDLKPQNILVT--SSGQIKLADFGLARIYSFQMALTSVV--------VTLWYRAPEVLL 192 H ++ +NI V Q+ LA +G A Y + V L + + ++ Sbjct: 182 HGNVTAENIFVDPEDQSQVTLAGYGFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMDLHK 241 Query: 193 QSSYATPVDLWSVGCIFAEMFRRKPLFRGS--SDVDQLGKILDVIGLPGEEDWP 244 + DL S+G + + + D + + + PG P Sbjct: 242 GCGPSRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFVGP 295 >5DMZ-A nrPDB Length = 365 Score = 73.4 bits (179), Expect = 1e-13, Method: Composition-based stats. Identities = 48/307 (15%), Positives = 103/307 (33%), Gaps = 56/307 (18%) Query: 8 RADQQYECVAEI-------GEGAYGKVFKAR-----DLKNGGRFVALKRVRVQTGEEGMP 55 + +++ +++ GEGA+ +V++A D KN +FV ++ + P Sbjct: 55 KPKTEFQLGSKLVYVHHLLGEGAFAQVYEATQGDLNDAKNKQKFV------LKVQKPANP 108 Query: 56 LSTIREVAVLRHLE-TFEHPNVVRLFDVCTVSRTDRETKLTLVFE-HVDQDLTT---YLD 110 ++ L+ + +H ++ + LV E + L Sbjct: 109 WEFYIGTQLMERLKPSMQHMF-MKFYSAHLFQNGS-----VLVGELYSYGTLLNAINLYK 162 Query: 111 KVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQ-----------I 159 PE +P + ++L ++ +H ++H D+KP N ++ + + Sbjct: 163 NTPEKVMPQGLVISFAMRMLYMIEQVHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGL 222 Query: 160 KLADFGLA---RIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRK 216 L D G + +++ T+ T ++ E+L + +D + V M Sbjct: 223 ALIDLGQSIDMKLFPKGTIFTAKCETSGFQCVEMLSNKPWNYQIDYFGVAATVYCMLFG- 281 Query: 217 PLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDL 276 K+ + G E R LP ++ + DL Sbjct: 282 ----------TYMKVKNEGGECKPEGLFR--RLPHLDMWNEFFHVMLNIPDCHHLPSLDL 329 Query: 277 LLKCLTF 283 L + L Sbjct: 330 LRQKLKK 336 >4O1O-A nrPDB Length = 717 Score = 70.7 bits (172), Expect = 8e-13, Method: Composition-based stats. Identities = 56/307 (18%), Positives = 98/307 (31%), Gaps = 81/307 (26%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLE 69 D++Y+ A G ++ + VA+KR + EV+ L+ Sbjct: 349 DEEYKIADT----AEGGIYLGLY---EDQEVAVKRFSEGSTRGQQ------EVSCLQ--S 393 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTET---IKDMM 126 + + NVV + + L + + L +L VP E ++++ Sbjct: 394 SRANDNVVTFYG-----SESDGSCLHVCLALCEYTLQEHLANHRGDAVPNEEDESARNIL 448 Query: 127 FQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYR 186 L + + LH H+DL+PQNIL+ S LADF ++ Sbjct: 449 SSLFKAIGELHRSGYSHQDLQPQNILIDSKNGTFLADF--------DKSIK--------- 491 Query: 187 APEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRD 246 W+ D ++ + L+ +GL + Sbjct: 492 ----------------WA------------------EDPQKIKRDLEALGLLVLYVVKKG 517 Query: 247 VALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTF--NPAKRISAYSALSHPYFQDLE 304 K+ E DE +DL+ N R+S+ L+HP+F E Sbjct: 518 DISFETL---KNQSFEEVIQGSPDEETRDLIHHLFHPGDNVEDRLSS--LLAHPFFWSWE 572 Query: 305 RCKENLD 311 L Sbjct: 573 SRYRTLR 579 >6G4J-A nrPDB Length = 315 Score = 68.0 bits (165), Expect = 5e-12, Method: Composition-based stats. Identities = 46/159 (28%), Positives = 65/159 (40%), Gaps = 23/159 (14%) Query: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 Y ++G+GA G V+ A + VALK LS EV VL+ + Sbjct: 28 YTLRKQLGKGANGIVYLA---ETSDGHVALKV-------SDDSLSITSEVNVLKSFSKAQ 77 Query: 73 H----PNVVRLFDVCTVSRTDRETKLTL-VFEHVDQDLTTYLDKVPEPGVPTETIKDMMF 127 P+ FD TK++ E++ L L V + G E I +M Sbjct: 78 SVTMGPS---FFDTDDAYIPSANTKVSFYAMEYIKGPL--LLKYVSDKG--AEWIPVLMI 130 Query: 128 QLLRGLDFLHSHRVVHRDLKPQNILVTS-SGQIKLADFG 165 QLL L LH + DLKP N++VT +I+ D G Sbjct: 131 QLLSSLSVLHQQGWIFGDLKPDNLIVTGPPARIRCIDVG 169 >6EWX-A nrPDB Length = 484 Score = 66.5 bits (161), Expect = 1e-11, Method: Composition-based stats. Identities = 41/252 (16%), Positives = 71/252 (28%), Gaps = 70/252 (27%) Query: 110 DKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSG------------ 157 EP V + ++ QL GL+ L H ++HRDL +N+L+ Sbjct: 200 SHRAEPEVYERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLVHCNPQSSPGPSANPS 259 Query: 158 -----------------------------QIKLADFGLARIYSFQMALTSVVVTLWYRAP 188 ++ +++F A+ + AP Sbjct: 260 VPTTTSRCPSAAPAATTACQGGPGEKHLPRLIISNFLKAKQKPGGTTNLQQKKSQARLAP 319 Query: 189 EVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA 248 E++ S Y D + G + E+ + F A Sbjct: 320 EIVSASQY-RKFDEFQTGILIYELLHQPNPFE-------------------------VRA 353 Query: 249 LPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKE 308 R+ + + P ++ + L L +P KRI A Q L Sbjct: 354 QLRERDYRREDLPPLPTLSLYSPGLQQLAHLLLEADPIKRIRIGEAKR--VLQCLLWGPR 411 Query: 309 NLDSHLP-PSQN 319 P PS+ Sbjct: 412 RELVEQPCPSEE 423 >4OAU-C nrPDB Length = 699 Score = 66.1 bits (160), Expect = 2e-11, Method: Composition-based stats. Identities = 36/159 (22%), Positives = 61/159 (38%), Gaps = 24/159 (15%) Query: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLE 69 D++Y+ + G ++ K + VA+K + REV+ L+ Sbjct: 346 DEKYKIADT----SEGGIYLGFYEK---QEVAVKTFCEGSP------RAQREVSCLQSSR 392 Query: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTET---IKDMM 126 H +V + L + +Q L LD V E ++++ Sbjct: 393 ENSH--LVTFYG-----SESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVL 445 Query: 127 FQLLRGLDFLH-SHRVVHRDLKPQNILVTSSGQIKLADF 164 + + + LH S H+DL+PQNIL+ S LADF Sbjct: 446 SSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADF 484 >4CZY-B nrPDB Length = 429 Score = 61.9 bits (149), Expect = 4e-10, Method: Composition-based stats. Identities = 47/278 (16%), Positives = 96/278 (34%), Gaps = 51/278 (18%) Query: 28 FKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREV-AVLRHLETFEHPNVVRLFDVCTVS 86 +KA++ KN GR AL+R+ EG L+ + + V + + + N+V + + T Sbjct: 61 YKAQNNKN-GRHFALRRI------EGYRLTNEKAILNVTKEWKKIINANIVTVHEAFT-- 111 Query: 87 RTDRETKLTLVFEHVDQDLTTYLDKVPEP------------GVPTETIKDMMFQLLRGLD 134 T+ +L+F + L+ L P +P + + Q+ L Sbjct: 112 -TEFFGDSSLIFVYDFHPLSETLYDHHFPPNNSHNRLRNTNKIPENLLWSYVCQIANALL 170 Query: 135 FLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQS 194 +H+ ++ R L+ I + + +I+LA + + + E L Q Sbjct: 171 AIHNAKLAARCLELSKI-IWENNRIRLAACSILDVLHHDSPNRKTI--------EELQQE 221 Query: 195 SYATPVDLWSVGCIFAEMFRRKPLFRGSSDVD------------QLGKILDVIGLPGEED 242 + G I + +++D QL +L+ + P Sbjct: 222 DFVK------FGRIILALAT-NTPTLNFNNIDAALATIVPRYSTQLRGVLEWLIKPSAPG 274 Query: 243 WPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKC 280 + V + A + + DE L+ + Sbjct: 275 ETKTVETLLGGITTHLANFANFVMQESDEKEFHLMREL 312 >6BHC-A nrPDB Length = 438 Score = 59.9 bits (144), Expect = 1e-09, Method: Composition-based stats. Identities = 54/306 (17%), Positives = 102/306 (33%), Gaps = 72/306 (23%) Query: 28 FKARDLKNGGRFVALKRVRVQTGEEGM---PLSTIREVAVLRHLE-TFEH-----PNVVR 78 + A K+ A+K + + E L+ + +AV +++ H PN R Sbjct: 74 YTASYAKDPLNNYAVKICKSKAKESQQYYHSLAVRQSLAVHFNIQQDCGHFLAEVPN--R 131 Query: 79 LFDVCTVSRTDRETKLTL--------VFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130 L S+ R + + V + V L + P + + ++ QL Sbjct: 132 LLPWEDPSKKQRSHVVVITREVPCLTVADFVRDSLAQH---GKSPDLYERQVCLLLLQLC 188 Query: 131 RGLDFLHSHRVVHRDLKPQNILVTS---SGQIKLADFGLARIYSFQMALTSVVVT----- 182 GL+ L + V H DL+ +N+L+ G + FG A T ++V+ Sbjct: 189 SGLEHLKPYHVTHCDLRLENLLLVHYQPGGTAQ--GFGPAEPTPTSSYPTRLIVSNFSQA 246 Query: 183 --------LWY------RAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQL 228 APE++ + Y D + G + EM F + ++ Sbjct: 247 KQKSHLVDPEILRDQSRLAPEIITATQY-KKCDEFQTGILIYEMLHLPNPFDENPEL--- 302 Query: 229 GKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKR 288 ++ ++++ P F + + L L NP++R Sbjct: 303 ----------------------KEREYTRADLPRIPFRSPYSRGLQQLASCLLNPNPSER 340 Query: 289 ISAYSA 294 I A Sbjct: 341 ILISDA 346 >6M7Z-A nrPDB Length = 319 Score = 56.9 bits (136), Expect = 1e-08, Method: Composition-based stats. Identities = 37/220 (16%), Positives = 67/220 (30%), Gaps = 51/220 (23%) Query: 94 LTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILV 153 LT +F + + L + E G ++ + ++ L LH+ ++HR ++ + V Sbjct: 121 LTYIFHPLSKGLVGDM---LETGRSHPDVQVLAANMVAALKSLHNLGLLHRSIELNSFSV 177 Query: 154 TSSGQIKLADFGLARIYSFQMALTSVVVTLWY-RAPEV---------LLQSSYATPVDLW 203 G + L GL V APE+ L Q + D++ Sbjct: 178 LPDGTVVLG--GLDTAAPIGTETRLWVGFFGQETAPEIDRNFLADLALTQGRHTVKSDVY 235 Query: 204 SVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIE 263 S+G ++ ++G P D RQ + Sbjct: 236 SLGV-------------------AFRNLVQLLG--NGNLGPEDRGAVRQDHLELLDK--- 271 Query: 264 KFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDL 303 L K + P R + + P F+ L Sbjct: 272 ------------LSQKMIEEEPGNRPTIEEIMKDPLFEGL 299 >6G38-A nrPDB Length = 357 Score = 54.9 bits (131), Expect = 5e-08, Method: Composition-based stats. Identities = 34/183 (18%), Positives = 62/183 (33%), Gaps = 43/183 (23%) Query: 7 CRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQ------TGEEGMPLSTIR 60 C ++ + +IGEG +G+VF+ VA+K + ++ + + Sbjct: 37 CLPTEKLQRCEKIGEGVFGEVFQ---TIADHTPVAIKIIAIEGPDLVNGSHQKTFEEILP 93 Query: 61 EVAVLRHLETFEHP-----------NVVRL---------------FDVCTVSRTDR---- 90 E+ + + L N V ++ S DR Sbjct: 94 EIIISKELSLLSGEVCNRTEGFIGLNSVHCVQGSYPPLLLKAWDHYNSTKGSANDRPDFF 153 Query: 91 -ETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLH-SHRVVHRDLKP 148 + +L +V E + L+++ T K ++ QL L S R HRDL Sbjct: 154 KDDQLFIVLEFEFGGID--LEQMRTKLSSLATAKSILHQLTASLAVAEASLRFEHRDLHW 211 Query: 149 QNI 151 N+ Sbjct: 212 GNV 214 >5GZ9-A nrPDB Length = 305 Score = 53.4 bits (127), Expect = 1e-07, Method: Composition-based stats. Identities = 40/217 (18%), Positives = 70/217 (32%), Gaps = 46/217 (21%) Query: 16 VAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPN 75 + +GEGA V + + VAL R+ +E L+ L++ + + Sbjct: 39 LKRVGEGA---VKRVFLSEWKEHKVALSRLTRLEMKEDFLHG-------LQMLKSLQSEH 88 Query: 76 VVRLFDVCTVSRTDRETKLTLVFEHVD----QDLTTYLDKVPEPGV-PTETIKDMMFQLL 130 VV L C T ++ E+ +L L V + + + + Sbjct: 89 VVTLVGYCEEDGT-------ILTEYHPLGSLSNLEETLQLSKYQDVNTWQHRLQLAMEYV 141 Query: 131 RGLDFLHSHRVVHRDLKPQN--------ILVTSSGQIKLADFGLARIYSFQMALTSVVVT 182 +++LH + R + N L+TS+ I D + + Sbjct: 142 SIINYLHHSPLGTRVMCDSNDLPKTLSQYLLTSNFSIVANDLDALPLVDHDSGVLIKCGH 201 Query: 183 LW----YRAPEVL------------LQSSYATPVDLW 203 + APE L L SY VD+W Sbjct: 202 RELHGDFVAPEQLWPYGEDTPFQDDLMPSYNEKVDIW 238 >4AZV-A nrPDB Length = 569 Score = 52.6 bits (125), Expect = 2e-07, Method: Composition-based stats. Identities = 19/71 (26%), Positives = 31/71 (43%), Gaps = 4/71 (5%) Query: 95 TLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVT 154 LV E + L + + E + ++ LLR L L H D++P N++V Sbjct: 318 WLVMEKLPGRLLSDMLAAGE----EIDREKILGSLLRSLAALEKQGFWHDDVRPWNVMVD 373 Query: 155 SSGQIKLADFG 165 + +L DFG Sbjct: 374 ARQHARLIDFG 384 >4AZW-A nrPDB Length = 471 Score = 52.2 bits (124), Expect = 3e-07, Method: Composition-based stats. Identities = 19/71 (26%), Positives = 31/71 (43%), Gaps = 4/71 (5%) Query: 95 TLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVT 154 LV E + L + + E + ++ LLR L L H D++P N++V Sbjct: 318 WLVMEKLPGRLLSDMLAAGE----EIDREKILGSLLRSLAALEKKGFWHDDVRPWNVMVD 373 Query: 155 SSGQIKLADFG 165 + +L DFG Sbjct: 374 ARQHARLIDFG 384 >3Q60-A nrPDB Length = 371 Score = 51.1 bits (121), Expect = 6e-07, Method: Composition-based stats. Identities = 57/330 (17%), Positives = 105/330 (31%), Gaps = 62/330 (18%) Query: 6 LCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREV--- 62 L + +++ + V + G VF RD++ ALK + L + E Sbjct: 57 LSQGERKLKLVEPLRVGDRSVVFLVRDVER-LEDFALKVFTMGAENSRSELERLHEATFA 115 Query: 63 ---------AVLRHLETFEHPNVVRLFDVCTVSRTDRETKLT------------LVF--- 98 R P+ D V +L+ L+ Sbjct: 116 AARLLGESPEEARDRRRLLLPS-----DAVAVQSQPPFAQLSPGQDDYAVANYLLLMPAA 170 Query: 99 ----EHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVT 154 E + L + G+ I + QL+R L S +VH P N+ + Sbjct: 171 SVDLELLFSTLDFVYVFRGDEGILALHI--LTAQLIRLAANLQSKGLVHGHFTPDNLFIM 228 Query: 155 SSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQS--SYATPVDLWSVGCIFAEM 212 G++ L D ++ ++ + V + Y E L S ++ ++ W +G + Sbjct: 229 PDGRLMLGD--VSALWKVGTRGPASSVPVTYAPREFLNASTATFTHALNAWQLGLSIYRV 286 Query: 213 FRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDEL 272 + F + G+ G P + S P+ FV Sbjct: 287 WCLFLPFGLVTP-----------GIKGSWKRPSLRVPGTDSLAFGSCTPLPDFV------ 329 Query: 273 GKDLLLKCLTFNPAKRISAYSALSHP-YFQ 301 K L+ + L F+ +R+ A+ P + Q Sbjct: 330 -KTLIGRFLNFDRRRRLLPLEAMETPEFLQ 358 >5GZA-A nrPDB Length = 290 Score = 50.3 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 43/221 (19%), Positives = 68/221 (30%), Gaps = 51/221 (23%) Query: 14 ECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEH 73 V IG+GA V K + G+ VAL + + + +++LR L++ Sbjct: 28 RRVKLIGQGA---VKKVYLSEWQGQKVALSVL----SSDQYADDFLHGLSMLRALQSS-- 78 Query: 74 PNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLD-----KVPEPGVPTETIKDMMFQ 128 +VV L VC V E+ LD + T + Sbjct: 79 -HVVTLVGVCEEDA-------VFVTEYHPLGSVLTLDTTLAQERYRWRNSWHTRLQLAID 130 Query: 129 LLRGLDFLHSH----------RVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTS 178 + L +LHS +H+ L L+ S ++ D A + L Sbjct: 131 YVAFLAYLHSSPAGIRVMCDSNDLHKTL--SQFLLASDMRLLANDLD-ALPEVEKGGLGV 187 Query: 179 VVV----TLWYRAPEVL------------LQSSYATPVDLW 203 T + APE L Y D+W Sbjct: 188 KCGHHELTGDFVAPEQLWPYGEDFSFSDEAMPGYDEKTDIW 228 >5VE6-A nrPDB Length = 492 Score = 49.5 bits (117), Expect = 2e-06, Method: Composition-based stats. Identities = 14/46 (30%), Positives = 23/46 (50%) Query: 110 DKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTS 155 EP + ++ QL GL+ L H ++HRDL +N+L+ Sbjct: 198 SHQAEPEAYERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLVH 243 Score = 40.3 bits (93), Expect = 0.001, Method: Composition-based stats. Identities = 19/111 (17%), Positives = 32/111 (28%), Gaps = 26/111 (23%) Query: 186 RAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPR 245 APE++ S Y D + G + E+ + F Sbjct: 325 LAPEIVSASQY-RKFDEFQTGILIYELLHQPNPFE------------------------- 358 Query: 246 DVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALS 296 A R+ + + P ++ + L L +P KRI A Sbjct: 359 VRAQLRERDYRQEDLPPLPALSLYSPGLQQLAHLLLEADPIKRIRIGEAKR 409 >3BYV-A nrPDB Length = 377 Score = 48.4 bits (114), Expect = 4e-06, Method: Composition-based stats. Identities = 36/217 (16%), Positives = 66/217 (30%), Gaps = 48/217 (22%) Query: 110 DKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARI 169 + + Q++R L LH + +VH L+P +I++ G + L F Sbjct: 196 HSSTHKSLVHHARLQLTLQVIRLLASLHHYGLVHTYLRPVDIVLDQRGGVFLTGF---EH 252 Query: 170 YSFQMALTSVVVTLWYRAPEV------LLQSS-----YATPVDLWSVGCIFAEMFRRKPL 218 A V+ + PE+ + D W++G + ++ Sbjct: 253 LVRDGARVVSSVSRGFEPPELEARRATISYHRDRRTLMTFSFDAWALGLVIYWIWCADLP 312 Query: 219 FRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLL 278 I L G E R +I + + LL Sbjct: 313 ------------ITKDAALGGSEWIFRSCK-------------------NIPQPVRALLE 341 Query: 279 KCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLP 315 L + R+ A+ P + E+ + L + LP Sbjct: 342 GFLRYPKEDRLLPLQAMETP---EYEQLRTELSAALP 375 >4BWP-A nrPDB Length = 448 Score = 48.0 bits (113), Expect = 6e-06, Method: Composition-based stats. Identities = 34/170 (20%), Positives = 58/170 (34%), Gaps = 42/170 (24%) Query: 28 FKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSR 87 ++A G ++ +R G + V + + +H NVV+L +V T Sbjct: 67 YRATHNTTGYKYC----LRRIHGFRLQSTKCMTLVEM---WKKLQHTNVVQLREVFTTKA 119 Query: 88 TDRETKLTLVFEHVDQD---LTTYLDKVPE---------------------------PGV 117 + L LV+++ L Y PE P + Sbjct: 120 FG-DNSLVLVYDYHPGSQTLLAKYFTPAPETNGYTDPFQGEARPFSHKSNMQRTSNGPLL 178 Query: 118 PTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSS----GQIKLAD 163 P TI ++ QL GL +H + + L P I+VT ++D Sbjct: 179 PEATIWSIIMQLTAGLKAIHHAGLACKVLDPTKIIVTGKRVRFSSCCISD 228 >3ENH-A nrPDB Length = 540 Score = 47.6 bits (112), Expect = 7e-06, Method: Composition-based stats. Identities = 28/159 (17%), Positives = 58/159 (36%), Gaps = 22/159 (13%) Query: 19 IGEGAYGKVFKARDLKNG--GRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNV 76 IG+GA +A ++ V +K + + IR+ R + Sbjct: 344 IGKGA-----EADIKRDSYLDFDVIIKERVKKGYRDERLDENIRKSRTAREARYLA---L 395 Query: 77 VRLFDVCTVSRTDRE-TKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDF 135 V+ F + D + ++ +++ L + E D+ +++ + Sbjct: 396 VKDFGIPAPYIFDVDLDNKRIMMSYINGKLAKDV---------IEDNLDIAYKIGEIVGK 446 Query: 136 LHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQM 174 LH + V+H DL N + + + DFGL +I + Sbjct: 447 LHKNDVIHNDLTTSNFIFDKD--LYIIDFGLGKISNLDE 483 >3DZO-A nrPDB Length = 413 Score = 43.4 bits (101), Expect = 1e-04, Method: Composition-based stats. Identities = 34/216 (15%), Positives = 70/216 (32%), Gaps = 47/216 (21%) Query: 110 DKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARI 169 + + Q++R L LH + +VH L+P +I++ G + L F + Sbjct: 201 HSSTHKSLVHHARLQLTLQVIRLLASLHHYGLVHTYLRPVDIVLDQRGGVFLTGFE--HL 258 Query: 170 YSFQMALTSVVVTLWYRAPE------VLLQSSY----ATPVDLWSVGCIFAEMFRRKPLF 219 + S + + PE + + D W++G ++ Sbjct: 259 VRDGASAVSPIG-RGFAPPETTAERMLPFGQHHPTLMTFAFDTWTLGLAIYWIWCADLP- 316 Query: 220 RGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLK 279 ++D LG ++ I + +I + + LL Sbjct: 317 --NTDDAALG----------------------------GSEWIFRSCKNIPQPVRALLEG 346 Query: 280 CLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLP 315 L + R+ A+ P + E+ + L + LP Sbjct: 347 FLRYPKEDRLLPLQAMETP---EYEQLRTELSAALP 379 >2W1Z-A nrPDB Length = 368 Score = 43.0 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 31/197 (15%), Positives = 63/197 (31%), Gaps = 44/197 (22%) Query: 110 DKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARI 169 + + QL+R L + +VH D + +NIL+ G + L F + Sbjct: 181 HSSTHKSLVHHARLQLTLQLIRLAASLQHYGLVHADFQVRNILLDQRGGVFLTGFE--HL 238 Query: 170 YSFQMALTSVVVTLWYRAPE-----VLLQSSY-----ATPVDLWSVGCIFAEMFRRKPLF 219 + S + + PE +L + P D W++G ++ Sbjct: 239 VRDGASAVSPIG-RGFAPPETTAERMLPYRQHHPTLMTFPFDTWTLGLAIYWIWCADLP- 296 Query: 220 RGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLK 279 +++ +LG I + I + +I + + LL Sbjct: 297 --NTEDAELGGI----------------------------EWIYRRCKNIPQPVRALLEG 326 Query: 280 CLTFNPAKRISAYSALS 296 L ++ R+ A+ Sbjct: 327 FLRYSKEDRLLPLQAME 343 >6G18-v nrPDB Length = 552 Score = 41.4 bits (96), Expect = 5e-04, Method: Composition-based stats. Identities = 20/110 (18%), Positives = 43/110 (39%), Gaps = 17/110 (15%) Query: 55 PLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPE 114 LS ++E A ++ L + P V + + +V E ++ + V + Sbjct: 155 RLSAMKEFAYMKALYERKFP----------VPKPIDYNRHAVVMELINGYPLCQIHHVED 204 Query: 115 PGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADF 164 P + +++ +L H ++H D N+++ S I + DF Sbjct: 205 PASVYDEAMELIVKLAN-------HGLIHGDFNEFNLILDESDHITMIDF 247 >6FDN-A nrPDB Length = 320 Score = 40.3 bits (93), Expect = 0.001, Method: Composition-based stats. Identities = 20/110 (18%), Positives = 43/110 (39%), Gaps = 17/110 (15%) Query: 55 PLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPE 114 LS ++E A ++ L + P V + + +V E ++ + V + Sbjct: 155 RLSAMKEFAYMKALYERKFP----------VPKPIDYNRHAVVMELINGYPLCQIHHVED 204 Query: 115 PGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADF 164 P + +++ +L H ++H D N+++ S I + DF Sbjct: 205 PASVYDEAMELIVKLAN-------HGLIHGDFNEFNLILDESDHITMIDF 247 >4WWA-A nrPDB Length = 261 Score = 38.4 bits (88), Expect = 0.004, Method: Composition-based stats. Identities = 26/136 (19%), Positives = 49/136 (36%), Gaps = 19/136 (13%) Query: 43 KRVRVQTGEEGM-PLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHV 101 KR R ++ + T+ E +L L + L ++ + L E + Sbjct: 57 KRYRHPQIDQALTKHRTLNESRLLAKLYL-----IPGLCVPQLIACDPYNGFIWL--EFL 109 Query: 102 DQDL--------TTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILV 153 +DL + + ++ + + ++ R + LH + H DL NI++ Sbjct: 110 GEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVL 169 Query: 154 TSSG---QIKLADFGL 166 G L DFGL Sbjct: 170 VRDGARWTPHLIDFGL 185 >6DFL-A nrPDB Length = 259 Score = 35.7 bits (81), Expect = 0.033, Method: Composition-based stats. Identities = 19/107 (17%), Positives = 35/107 (32%), Gaps = 3/107 (2%) Query: 82 VCTVSRTDRETKLTLVFEHVDQ--DLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSH 139 +V E + DL + E P + ++ + R + +H Sbjct: 98 YGERGSDPARQHSFIVTEELAPTVDLEVFSQDWRERPPPPRLKRALVEAVARMVGDMHRA 157 Query: 140 RVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYR 186 V HRD + L+ + + DF L+ + A T +R Sbjct: 158 GVNHRDCYICHFLLHTDKPVSADDFRLS-VIDLHRAQTRDATPKRWR 203 >1TQM-A nrPDB Length = 282 Score = 35.3 bits (80), Expect = 0.038, Method: Composition-based stats. Identities = 32/164 (19%), Positives = 53/164 (32%), Gaps = 35/164 (21%) Query: 15 CVAEIGEGAYGKVFKARDLKNGGRFV--------ALKRVRVQTGEEGMPLSTI------R 60 +GEG VF K G V + K+V+ + + S + Sbjct: 94 IGKLMGEGKESAVFNCYSEKFGECVVKFHKVGHTSFKKVKEKRDYGDLHFSVLAIRSARN 153 Query: 61 EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTE 120 E L+ L+ P V + L +D V E Sbjct: 154 EFRALQKLQGLAVPKVYAWEG--------------------NAVLMELIDAKELYRVRVE 193 Query: 121 TIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADF 164 +++ +L + + +VH DL N+LV+ G I + DF Sbjct: 194 NPDEVLDMILEEVAKFYHRGIVHGDLSQYNVLVSEEG-IWIIDF 236 >5YK0-A nrPDB Length = 452 Score = 33.4 bits (75), Expect = 0.13, Method: Composition-based stats. Identities = 8/26 (30%), Positives = 15/26 (57%) Query: 140 RVVHRDLKPQNILVTSSGQIKLADFG 165 ++H D P N ++ G++ + DFG Sbjct: 286 GLMHGDAHPGNFMLLPDGRMGIIDFG 311 >5JY7-I nrPDB Length = 441 Score = 32.6 bits (73), Expect = 0.24, Method: Composition-based stats. Identities = 9/43 (20%), Positives = 14/43 (32%) Query: 62 VAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQD 104 + + R L +P+V RL L +V E Sbjct: 158 IELNRVLARAGNPHVARLLGSFETEWEGEPYALGMVTEFAANS 200 >4BVU-A nrPDB Length = 211 Score = 31.4 bits (70), Expect = 0.49, Method: Composition-based stats. Identities = 22/151 (14%), Positives = 51/151 (33%), Gaps = 22/151 (14%) Query: 15 CVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHP 74 IG+G+ ++F+ D+ + K+ + + L + + L + + Sbjct: 44 LGKLIGQGSTAEIFE--DVNDSSALY--KKYDLIGNQYNEILEMAWQESELFNAFYGDEA 99 Query: 75 NVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLD 134 +VV + + L V + +D +P + + + Sbjct: 100 SVVIQYG----------GDVYLRMLRVPGTPLSDIDTA---DIPDNIESLYLQLICK--- 143 Query: 135 FLHSHRVVHRDLKPQNILVTSSGQ-IKLADF 164 L+ ++H DL N+L + + DF Sbjct: 144 -LNELSIIHYDLNTGNMLYDKESESLFPIDF 173 >1VHE-A nrPDB Length = 373 Score = 31.0 bits (69), Expect = 0.70, Method: Composition-based stats. Identities = 11/26 (42%), Positives = 17/26 (65%), Gaps = 2/26 (7%) Query: 62 VAVLRHLETFEHPNVVRLFDVCTVSR 87 + VLR+L+ +HPN+V + V TV Sbjct: 193 IDVLRNLQNTDHPNIV--YGVGTVQE 216 >6EN4-C nrPDB Length = 852 Score = 31.0 bits (69), Expect = 0.73, Method: Composition-based stats. Identities = 12/76 (15%), Positives = 27/76 (35%), Gaps = 7/76 (9%) Query: 205 VGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEK 264 +G + E + S + L I++VIG+ + P + + ++ Sbjct: 522 LGVVLYEYLGEEYPEVLGSILGALKAIVNVIGM-------HKMTPPIKDLLPRLTPILKN 574 Query: 265 FVTDIDELGKDLLLKC 280 + E DL+ + Sbjct: 575 RHEKVQENCIDLVGRI 590 >6FAI-l nrPDB Length = 425 Score = 30.3 bits (67), Expect = 1.3, Method: Composition-based stats. Identities = 26/177 (14%), Positives = 48/177 (27%), Gaps = 42/177 (23%) Query: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRV----------------RVQTGEEGMPL 56 Y IG G ++K D R + + R+ + G M L Sbjct: 95 YSVGNTIGVGKESDIYKVSDKNGNPRVMKIHRLGRTSFHSVRNNRDYLKKSNQGANWMHL 154 Query: 57 STI---REVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVP 113 S + +E + L + V ++ +V E ++ L K Sbjct: 155 SRLAANKEYQFMSMLYSKG----------FKVPEPFDNSRHIVVMELIEGYPMRRLRKHK 204 Query: 114 EPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTS------SGQIKLADF 164 + + L ++H D NI++ + DF Sbjct: 205 NIPKLYSDLMCFIVDLAN-------SGLIHCDFNEFNIMIKDKLEDENDCGFVVIDF 254 >6EF6-A nrPDB Length = 354 Score = 29.9 bits (66), Expect = 1.5, Method: Composition-based stats. Identities = 11/28 (39%), Positives = 16/28 (57%), Gaps = 3/28 (10%) Query: 140 RVVHRDLKPQNILVTSS---GQIKLADF 164 ++H DL+ N+LV SS I + DF Sbjct: 226 GLIHADLRLANLLVDSSTPQRTITVIDF 253 >3F7W-A nrPDB Length = 288 Score = 29.5 bits (65), Expect = 2.2, Method: Composition-based stats. Identities = 15/66 (22%), Positives = 28/66 (42%), Gaps = 4/66 (6%) Query: 100 HVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFL----HSHRVVHRDLKPQNILVTS 155 + +Q + YL + + G T ++ ++L LD L +H DL N+L Sbjct: 145 YAEQRILPYLRRAADRGALTPGDVRLVEKVLDALDHLAGDPEPPARIHGDLWNGNVLWQD 204 Query: 156 SGQIKL 161 G + + Sbjct: 205 DGAVVI 210 >2EG4-A nrPDB Length = 230 Score = 29.1 bits (64), Expect = 2.5, Method: Composition-based stats. Identities = 30/180 (16%), Positives = 54/180 (30%), Gaps = 51/180 (28%) Query: 137 HSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSY 196 H H DL + + ++K + + LT + TL R+P VL Sbjct: 22 HLPGARHLDLSAPKLRLREEAELK----------ALEGGLTELFQTLGLRSPVVLYDEGL 71 Query: 197 ATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHS 256 + R F G ++ E W + + + Sbjct: 72 TSR-------------LCRTAFFLGLGGLEV---------QLWTEGW--------EPYAT 101 Query: 257 KSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPP 316 + +P + + +L +D L ++A A HP D+ +E PP Sbjct: 102 EKEEPKPERTEVVAKLRRDWL-----------LTADEAARHPLLLDVRSPEEFQGKVHPP 150 >3TYK-A nrPDB Length = 362 Score = 28.7 bits (63), Expect = 3.9, Method: Composition-based stats. Identities = 9/49 (18%), Positives = 18/49 (36%) Query: 139 HRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRA 187 +VH D N+L + + D+ A Q + ++ + A Sbjct: 213 RHLVHADFGSNNVLTDNGRITAVIDWSEAMFGDSQYEVANIFFWRPWLA 261 >3MI6-A nrPDB Length = 745 Score = 27.6 bits (60), Expect = 7.9, Method: Composition-based stats. Identities = 11/42 (26%), Positives = 16/42 (38%), Gaps = 7/42 (16%) Query: 292 YSALSHP-------YFQDLERCKENLDSHLPPSQNTSELNTA 326 Y L+HP YF+ L + + P + EL A Sbjct: 669 YQLLNHPNAPYTRFYFKGLRPNQRYQINDDPSTYYGDELMNA 710 >2P8J-A nrPDB Length = 209 Score = 27.6 bits (60), Expect = 8.2, Method: Composition-based stats. Identities = 7/19 (36%), Positives = 11/19 (57%) Query: 6 LCRADQQYECVAEIGEGAY 24 L D++Y +IGEG + Sbjct: 129 LTTKDERYNKGEKIGEGEF 147 >5KBF-A nrPDB Length = 301 Score = 27.2 bits (59), Expect = 9.3, Method: Composition-based stats. Identities = 13/69 (18%), Positives = 24/69 (34%), Gaps = 5/69 (7%) Query: 43 KRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD 102 K + E+ + E + HL E +V F + E + ++ E Sbjct: 28 KVYKKDEKEKAKIREALNESFLFNHLNKKEFEIIVNAF-----FDKNVEKGVNIINEGDY 82 Query: 103 QDLTTYLDK 111 DL +D+ Sbjct: 83 GDLLYVIDQ 91 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.312 0.148 0.463 Lambda K H 0.267 0.0453 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 14,187,462 Number of Sequences: 36641 Number of extensions: 604975 Number of successful extensions: 6110 Number of sequences better than 10.0: 507 Number of HSP's better than 10.0 without gapping: 958 Number of HSP's successfully gapped in prelim test: 32 Number of HSP's that attempted gapping in prelim test: 1774 Number of HSP's gapped (non-prelim): 1201 length of query: 326 length of database: 10,336,785 effective HSP length: 97 effective length of query: 229 effective length of database: 6,782,608 effective search space: 1553217232 effective search space used: 1553217232 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.2 bits) S2: 60 (27.6 bits)