BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P96890 (600 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 5MLK-A nrPDB 1207 0.0 2C00-A nrPDB 386 e-107 2VPQ-A nrPDB 386 e-107 3U9T-A nrPDB 367 e-101 1ULZ-A nrPDB 366 e-101 4RZQ-A nrPDB 366 e-101 2DZD-A nrPDB 363 e-100 3JZF-A nrPDB 358 3e-99 3N6R-A nrPDB 354 8e-98 3OUU-A nrPDB 344 6e-95 5H80-A nrPDB 313 2e-85 5KS8-A nrPDB 220 1e-57 2YL2-A nrPDB 216 2e-56 3JRW-A nrPDB 204 6e-53 1W93-A nrPDB 194 9e-50 5KS8-C nrPDB 67 2e-11 2CQY-A nrPDB 65 6e-11 4HR7-B nrPDB 47 2e-05 1A6X-A nrPDB 47 2e-05 5CSA-A nrPDB 44 3e-04 6DGI-A nrPDB 42 0.001 3MJF-A nrPDB 36 0.050 2IP4-A nrPDB 36 0.050 4MAM-A nrPDB 36 0.062 1GSO-A nrPDB 35 0.074 5BPF-A nrPDB 35 0.094 2XD4-A nrPDB 35 0.096 2YS6-A nrPDB 35 0.10 3AX6-A nrPDB 33 0.24 1OBB-A nrPDB 33 0.48 3AW8-A nrPDB 32 0.62 3LWB-A nrPDB 32 0.66 5LIE-A nrPDB 32 0.68 4IZO-A nrPDB 32 0.93 1ZY8-K nrPDB 32 0.98 2O8R-A nrPDB 31 1.9 3WVR-A nrPDB 30 2.9 5VEV-A nrPDB 29 5.2 2CZG-A nrPDB 29 5.5 2YW2-A nrPDB 29 5.9 2KNJ-A nrPDB 29 6.4 4NAR-A nrPDB 28 8.1 4PYS-A nrPDB 28 8.3 >5MLK-A nrPDB Length = 614 Score = 1207 bits (3122), Expect = 0.0, Method: Compositional matrix adjust. Identities = 600/600 (100%), Positives = 600/600 (100%) Query: 1 MASHAGSRIARISKVLVANRGEIAVRVIRAARDAGLPSVAVYAEPDAESPHVRLADEAFA 60 MASHAGSRIARISKVLVANRGEIAVRVIRAARDAGLPSVAVYAEPDAESPHVRLADEAFA Sbjct: 15 MASHAGSRIARISKVLVANRGEIAVRVIRAARDAGLPSVAVYAEPDAESPHVRLADEAFA 74 Query: 61 LGGQTSAESYLDFAKILDAAAKSGANAIHPGYGFLAENADFAQAVIDAGLIWIGPSPQSI 120 LGGQTSAESYLDFAKILDAAAKSGANAIHPGYGFLAENADFAQAVIDAGLIWIGPSPQSI Sbjct: 75 LGGQTSAESYLDFAKILDAAAKSGANAIHPGYGFLAENADFAQAVIDAGLIWIGPSPQSI 134 Query: 121 RDLGDKVTARHIAARAQAPLVPGTPDPVKGADEVVAFAEEYGLPIAIKAAHGGGGKGMKV 180 RDLGDKVTARHIAARAQAPLVPGTPDPVKGADEVVAFAEEYGLPIAIKAAHGGGGKGMKV Sbjct: 135 RDLGDKVTARHIAARAQAPLVPGTPDPVKGADEVVAFAEEYGLPIAIKAAHGGGGKGMKV 194 Query: 181 ARTIDEIPELYESAVREATAAFGRGECYVERYLDKPRHVEAQVIADQHGNVVVAGTRDCS 240 ARTIDEIPELYESAVREATAAFGRGECYVERYLDKPRHVEAQVIADQHGNVVVAGTRDCS Sbjct: 195 ARTIDEIPELYESAVREATAAFGRGECYVERYLDKPRHVEAQVIADQHGNVVVAGTRDCS 254 Query: 241 LQRRYQKLVEEAPAPFLTDFQRKEIHDSAKRICKEAHYHGAGTVEYLVGQDGLISFLEVN 300 LQRRYQKLVEEAPAPFLTDFQRKEIHDSAKRICKEAHYHGAGTVEYLVGQDGLISFLEVN Sbjct: 255 LQRRYQKLVEEAPAPFLTDFQRKEIHDSAKRICKEAHYHGAGTVEYLVGQDGLISFLEVN 314 Query: 301 TRLQVEHPVTEETAGIDLVLQQFRIANGEKLDITEDPTPRGHAIEFRINGEDAGRNFLPA 360 TRLQVEHPVTEETAGIDLVLQQFRIANGEKLDITEDPTPRGHAIEFRINGEDAGRNFLPA Sbjct: 315 TRLQVEHPVTEETAGIDLVLQQFRIANGEKLDITEDPTPRGHAIEFRINGEDAGRNFLPA 374 Query: 361 PGPVTKFHPPSGPGVRVDSGVETGSVIGGQFDSMLAKLIVHGADRAEALARARRALNEFG 420 PGPVTKFHPPSGPGVRVDSGVETGSVIGGQFDSMLAKLIVHGADRAEALARARRALNEFG Sbjct: 375 PGPVTKFHPPSGPGVRVDSGVETGSVIGGQFDSMLAKLIVHGADRAEALARARRALNEFG 434 Query: 421 VEGLATVIPFHRAVVSDPAFIGDANGFSVHTRWIETEWNNTIEPFTDGEPLDEDARPRQK 480 VEGLATVIPFHRAVVSDPAFIGDANGFSVHTRWIETEWNNTIEPFTDGEPLDEDARPRQK Sbjct: 435 VEGLATVIPFHRAVVSDPAFIGDANGFSVHTRWIETEWNNTIEPFTDGEPLDEDARPRQK 494 Query: 481 VVVEIDGRRVEVSLPADLALSNGGGCDPVGVIRRKPKPRKRGAHTGAAASGDAVTAPMQG 540 VVVEIDGRRVEVSLPADLALSNGGGCDPVGVIRRKPKPRKRGAHTGAAASGDAVTAPMQG Sbjct: 495 VVVEIDGRRVEVSLPADLALSNGGGCDPVGVIRRKPKPRKRGAHTGAAASGDAVTAPMQG 554 Query: 541 TVVKFAVEEGQEVVAGDLVVVLEAMKMENPVTAHKDGTITGLAVEAGAAITQGTVLAEIK 600 TVVKFAVEEGQEVVAGDLVVVLEAMKMENPVTAHKDGTITGLAVEAGAAITQGTVLAEIK Sbjct: 555 TVVKFAVEEGQEVVAGDLVVVLEAMKMENPVTAHKDGTITGLAVEAGAAITQGTVLAEIK 614 >2C00-A nrPDB Length = 464 Score = 386 bits (992), Expect = e-107, Method: Compositional matrix adjust. Identities = 210/441 (47%), Positives = 292/441 (66%), Gaps = 6/441 (1%) Query: 12 ISKVLVANRGEIAVRVIRAARDAGLPSVAVYAEPDAESPHVRLADEAFALGGQTSAESYL 71 + KVL+ANRGEIA+R++RA ++ G+ +VAV++ D E H+ LADE+ +G + +SYL Sbjct: 2 LEKVLIANRGEIALRILRACKELGIKTVAVHSTADRELMHLSLADESVCIGPAPATQSYL 61 Query: 72 DFAKILDAAAKSGANAIHPGYGFLAENADFAQAVIDAGLIWIGPSPQSIRDLGDKVTARH 131 I+ AA +GA AIHPGYGFLAENADFA+ + +G ++GP+ + IR +GDKV+A+ Sbjct: 62 QIPAIIAAAEVTGATAIHPGYGFLAENADFAEQIERSGFTFVGPTAEVIRLMGDKVSAKD 121 Query: 132 IAARAQAPLVPGTPDPVKGADEV-VAFAEEYGLPIAIKAAHGGGGKGMKVARTIDEIPEL 190 RA P VPG+ P+ +E +A A E G P+ IKAA GGGG+GM+V E+ + Sbjct: 122 AMKRAGVPTVPGSDGPLPEDEETALAIAREVGYPVIIKAAGGGGGRGMRVVYDESELIKS 181 Query: 191 YESAVREATAAFGRGECYVERYLDKPRHVEAQVIADQHGNVVVAGTRDCSLQRRYQKLVE 250 + EA AAFG Y+E++L PRHVE QV++D GN + G RDCSLQRR+QK++E Sbjct: 182 AKLTRTEAGAAFGNPMVYLEKFLTNPRHVEVQVLSDGQGNAIHLGDRDCSLQRRHQKVIE 241 Query: 251 EAPAPFLTDFQRKEIHDSAKRICKEAHYHGAGTVEYLVGQDGLISFLEVNTRLQVEHPVT 310 EAPAP + + R+E+ + C E Y GAGT E+L ++G F+E+NTR+QVEHPV+ Sbjct: 242 EAPAPGIDEKARQEVFARCVQACIEIGYRGAGTFEFLY-ENGRFYFIEMNTRVQVEHPVS 300 Query: 311 EETAGIDLVLQQFRIANGEKLDI-TEDPTPRGHAIEFRINGEDAGRNFLPAPGPVTKFHP 369 E G+D+V + RIA+GEKL I ED RGHA+E RIN ED + F+P+PG V FH Sbjct: 301 EMVTGVDIVKEMLRIASGEKLSIRQEDVVIRGHALECRINAEDP-KTFMPSPGKVKHFHA 359 Query: 370 PSGPGVRVDSGVETGSVIGGQFDSMLAKLIVHGADRAEALARARRALNEFGVEGLATVIP 429 P G GVRVDS + +G + +DS++ K+I +GADR EALAR R AL+E V+G+ T Sbjct: 360 PGGNGVRVDSHLYSGYSVPPNYDSLVGKVITYGADRDEALARMRNALDELIVDGIKTNTE 419 Query: 430 FHRAVVSDPAFIGDANGFSVH 450 H+ +V D AF G ++H Sbjct: 420 LHKDLVRDAAFC--KGGVNIH 438 >2VPQ-A nrPDB Length = 451 Score = 386 bits (991), Expect = e-107, Method: Compositional matrix adjust. Identities = 201/431 (46%), Positives = 282/431 (65%), Gaps = 2/431 (0%) Query: 12 ISKVLVANRGEIAVRVIRAARDAGLPSVAVYAEPDAESPHVRLADEAFALGGQTSAESYL 71 + KVL+ANRGEIAVR+IRA RD G+ +VA+Y+E D ++ H ++ADEA+ +G S +SYL Sbjct: 1 MKKVLIANRGEIAVRIIRACRDLGIQTVAIYSEGDKDALHTQIADEAYCVGPTLSKDSYL 60 Query: 72 DFAKILDAAAKSGANAIHPGYGFLAENADFAQAVIDAGLIWIGPSPQSIRDLGDKVTARH 131 + IL A +G + +HPGYGFLAENADFA+ L +IGPS QSI+ +G K A+ Sbjct: 61 NIPNILSIATSTGCDGVHPGYGFLAENADFAELCEACQLKFIGPSYQSIQKMGIKDVAKA 120 Query: 132 IAARAQAPLVPGTPDPVKGADEVVAFAEEYGLPIAIKAAHGGGGKGMKVARTIDEIPELY 191 +A P+VPG+ +K E A++ G P+ IKA GGGGKG++VAR E+ + Sbjct: 121 EMIKANVPVVPGSDGLMKDVSEAKKIAKKIGYPVIIKATAGGGGKGIRVARDEKELETGF 180 Query: 192 ESAVREATAAFGRGECYVERYLDKPRHVEAQVIADQHGNVVVAGTRDCSLQRRYQKLVEE 251 +EA AFG G Y+E++++ RH+E Q++ D +GNV+ G RDC++QRR QKLVEE Sbjct: 181 RMTEQEAQTAFGNGGLYMEKFIENFRHIEIQIVGDSYGNVIHLGERDCTIQRRMQKLVEE 240 Query: 252 APAPFLTDFQRKEIHDSAKRICKEAHYHGAGTVEYLVG-QDGLISFLEVNTRLQVEHPVT 310 AP+P L D R+E+ ++A R K +Y AGT+E++ D F+E+NTR+QVEHPVT Sbjct: 241 APSPILDDETRREMGNAAVRAAKAVNYENAGTIEFIYDLNDNKFYFMEMNTRIQVEHPVT 300 Query: 311 EETAGIDLVLQQFRIANGEKLDIT-EDPTPRGHAIEFRINGEDAGRNFLPAPGPVTKFHP 369 E GIDLV Q ++A G+ L ED GHAIEFRIN E+ +NF+P+PG + ++ Sbjct: 301 EMVTGIDLVKLQLQVAMGDVLPYKQEDIKLTGHAIEFRINAENPYKNFMPSPGKIEQYLA 360 Query: 370 PSGPGVRVDSGVETGSVIGGQFDSMLAKLIVHGADRAEALARARRALNEFGVEGLATVIP 429 P G GVR++S T I +DSM+AKLI+H R EA+ RAL+EF V G+ T IP Sbjct: 361 PGGYGVRIESACYTNYTIPPYYDSMVAKLIIHEPTRDEAIMAGIRALSEFVVLGIDTTIP 420 Query: 430 FHRAVVSDPAF 440 FH ++++ F Sbjct: 421 FHIKLLNNDIF 431 >3U9T-A nrPDB Length = 655 Score = 367 bits (941), Expect = e-101, Method: Compositional matrix adjust. Identities = 263/643 (40%), Positives = 347/643 (53%), Gaps = 55/643 (8%) Query: 12 ISKVLVANRGEIAVRVIRAARDAGLPSVAVYAEPDAESPHVRLADEAFALGGQTSAESYL 71 I ++LVANRGEIA RV+R+AR G+ SVAV+++ D + HV AD A LGG A+SYL Sbjct: 8 IQRLLVANRGEIACRVMRSARALGIGSVAVHSDIDRHARHVAEADIAVDLGGAKPADSYL 67 Query: 72 DFAKILDAAAKSGANAIHPGYGFLAENADFAQAVIDAGLIWIGPSPQSIRDLGDKVTARH 131 +I+ AA SGA AIHPGYGFL+ENADFA+A +AGL+++GP +I +G K A+ Sbjct: 68 RGDRIIAAALASGAQAIHPGYGFLSENADFARACEEAGLLFLGPPAAAIDAMGSKSAAKA 127 Query: 132 IAARAQAPLVPGTPDPVKGADEVVAFAEEYGLPIAIKAAHGGGGKGMKVARTIDEIPELY 191 + A PLVPG + + A G P+ +KAA GGGGKGMKV E+ E Sbjct: 128 LMEEAGVPLVPGYHGEAQDLETFRREAGRIGYPVLLKAAAGGGGKGMKVVEREAELAEAL 187 Query: 192 ESAVREATAAFGRGECYVERYLDKPRHVEAQVIADQHGNVVVAGTRDCSLQRRYQKLVEE 251 SA REA AAFG VE+YL KPRHVE QV AD+HG+ + RDCS+QRR+QK+VEE Sbjct: 188 SSAQREAKAAFGDARMLVEKYLLKPRHVEIQVFADRHGHCLYLNERDCSIQRRHQKVVEE 247 Query: 252 APAPFLTDFQRKEIHDSAKRICKEAHYHGAGTVEYLVGQDGLISFLEVNTRLQVEHPVTE 311 APAP L R+ + ++A R + Y GAGTVE+L+ + G F+E+NTRLQVEHPVTE Sbjct: 248 APAPGLGAELRRAMGEAAVRAAQAIGYVGAGTVEFLLDERGQFFFMEMNTRLQVEHPVTE 307 Query: 312 ETAGIDLVLQQFRIANGEKLDITEDPTP-RGHAIEFRINGEDAGRNFLPAPGPVTKFH-P 369 G+DLV Q R+A GE L +T++ P GHAIE R+ ED +FLPA G + + Sbjct: 308 AITGLDLVAWQIRVARGEALPLTQEQVPLNGHAIEVRLYAEDPEGDFLPASGRLMLYREA 367 Query: 370 PSGPGVRVDSGVETGSVIGGQFDSMLAKLIVHGADRAEALARARRALNEFGVEGLATVIP 429 +GPG RVDSGV G + +D MLAKLI G R EA R L E V GL T + Sbjct: 368 AAGPGRRVDSGVREGDEVSPFYDPMLAKLIAWGETREEARQRLLAMLAETSVGGLRTNLA 427 Query: 430 FHRAVVSDPAFIG---DANGFSVHTRWI--------ETEWNNTIEPFTDGEP---LDED- 474 F R ++ PAF D + H + E W E + EP D+D Sbjct: 428 FLRRILGHPAFAAAELDTGFIARHQDDLLPAPQALPEHFWQAAAEAWLQSEPGHRRDDDP 487 Query: 475 --------------ARPRQKVVVEIDGR---RVEVSLPADLALSNGGGCDPVGVIRRKPK 517 AR ++ D R R+ + P+ L V + R+ Sbjct: 488 HSPWSRNDGWRSALARESDLMLRCRDERRCVRLRHASPSQYRLDGDDLVSRVDGVTRRSA 547 Query: 518 PRKRGAHTGAAASGD---------------------AVTAPMQGTVVKFAVEEGQEVVAG 556 +RG G+ ++APM G++V+ VE GQ V AG Sbjct: 548 ALRRGRQLFLEWEGELLAIEAVDPIAEAEAAHAHQGGLSAPMNGSIVRVLVEPGQTVEAG 607 Query: 557 DLVVVLEAMKMENPVTAHKDGTITGLAVEAGAAITQGTVLAEI 599 +VVLEAMKME+ + A G + L G + +GT L E+ Sbjct: 608 ATLVVLEAMKMEHSIRAPHAGVVKALYCSEGELVEEGTPLVEL 650 >1ULZ-A nrPDB Length = 451 Score = 366 bits (940), Expect = e-101, Method: Compositional matrix adjust. Identities = 195/445 (43%), Positives = 293/445 (65%), Gaps = 6/445 (1%) Query: 12 ISKVLVANRGEIAVRVIRAARDAGLPSVAVYAEPDAESPHVRLADEAFALGGQTSAESYL 71 ++KVLVANRGEIAVR+IRA ++ G+P+VA+Y E ++ + HV+LADEA+ +G ++YL Sbjct: 2 VNKVLVANRGEIAVRIIRACKELGIPTVAIYNEVESTARHVKLADEAYMIGTD-PLDTYL 60 Query: 72 DFAKILDAAAKSGANAIHPGYGFLAENADFAQAVIDAGLIWIGPSPQSIRDLGDKVTARH 131 + +I++ A + GA+AIHPGYGFLAENA+FA+ +AG+ +IGP + I +GDK ++ Sbjct: 61 NKQRIINLALEVGADAIHPGYGFLAENAEFAKMCEEAGITFIGPHWKVIELMGDKARSKE 120 Query: 132 IAARAQAPLVPGTPDPVKGADEVVAFAEEYGLPIAIKAAHGGGGKGMKVARTIDEIPELY 191 + +A P+VPG+ +K +E A A E G P+ +KA GGGG+G+++ R +E+ + Y Sbjct: 121 VMKKAGVPVVPGSDGVLKSLEEAKALAREIGYPVLLKATAGGGGRGIRICRNEEELVKNY 180 Query: 192 ESAVREATAAFGRGECYVERYLDKPRHVEAQVIADQHGNVVVAGTRDCSLQRRYQKLVEE 251 E A REA AFGRG+ +E++++ P+H+E QV+ D+HGNV+ G RDCS+QRR QKLVE Sbjct: 181 EQASREAEKAFGRGDLLLEKFIENPKHIEYQVLGDKHGNVIHLGERDCSIQRRNQKLVEI 240 Query: 252 APAPFLTDFQRKEIHDSAKRICKEAHYHGAGTVEYLVGQDGLISFLEVNTRLQVEHPVTE 311 AP+ LT +R+ + + KE Y+ AGT+E++ Q+G + F+E+NTR+QVEHPV+E Sbjct: 241 APSLILTPEKREYYGNIVTKAAKEIGYYNAGTMEFIADQEGNLYFIEMNTRIQVEHPVSE 300 Query: 312 ETAGIDLVLQQFRIANGEKLDIT-EDPTPRGHAIEFRINGEDAGRNFLPAPGPVTKFHPP 370 GID+V Q +IA GE L I ED G+AIE RIN ED +NF P+ + +++ P Sbjct: 301 MVTGIDIVKWQIKIAAGEPLTIKQEDVKFNGYAIECRINAEDPKKNFAPSTRVIERYYVP 360 Query: 371 SGPGVRVDSGVETGSVIGGQFDSMLAKLIVHGADRAEALARARRALNEFGVEGLATVIPF 430 G G+RV+ G + +DSM+AKLI EA+ R R AL + + G+ T IP Sbjct: 361 GGFGIRVEHAAARGFEVTPYYDSMIAKLITWAPTWDEAVERMRAALETYEITGVKTTIPL 420 Query: 431 HRAVVSDPAFIGDANGFSVHTRWIE 455 ++ + F A F+ T+++E Sbjct: 421 LINIMKEKDF--KAGKFT--TKYLE 441 >4RZQ-A nrPDB Length = 468 Score = 366 bits (939), Expect = e-101, Method: Compositional matrix adjust. Identities = 208/443 (46%), Positives = 284/443 (64%), Gaps = 10/443 (2%) Query: 12 ISKVLVANRGEIAVRVIRAARDAGLPSVAVYAEPDAESPHVRLADEAFALGGQTSAESYL 71 + KV++ANRGEIA+R++RA ++ G+ +VAV++ D + HV LADE +G SA+SYL Sbjct: 22 LEKVVIANRGEIALRILRACKELGIKTVAVHSTADRDLKHVLLADETICIGPAPSAKSYL 81 Query: 72 DFAKILDAAAKSGANAIHPGYGFLAENADFAQAVIDAGLIWIGPSPQSIRDLGDKVTARH 131 + I+ AA +GA+AIHPGYGFL+ENADFA+ V +G +IGP+ IR +GDKV+A Sbjct: 82 NIPAIIAAAEVTGADAIHPGYGFLSENADFAEQVERSGFTFIGPTADVIRLMGDKVSAIK 141 Query: 132 IAARAQAPLVPGTPDPVKGADEVVA---FAEEYGLPIAIKAAHGGGGKGMKVARTIDEIP 188 +A P VPG+ PV ++++ A+ G PI IKA+ GGGG+GM+V R+ D + Sbjct: 142 AMKKAGVPCVPGSDGPV--SNDIAKNKEIAKRIGYPIIIKASGGGGGRGMRVVRSEDALE 199 Query: 189 ELYESAVREATAAFGRGECYVERYLDKPRHVEAQVIADQHGNVVVAGTRDCSLQRRYQKL 248 E EA AAF Y+E+YL+ PRHVE QV+AD HGN V RDCS+QRR+QK+ Sbjct: 200 ESIAMTKAEAKAAFNNDMVYMEKYLENPRHVEIQVLADTHGNAVYLAERDCSMQRRHQKV 259 Query: 249 VEEAPAPFLTDFQRKEIHDSAKRICKEAHYHGAGTVEYLVGQDGLISFLEVNTRLQVEHP 308 VEEAPAP +T+ R++I C E Y GAGT E+L ++G F+E+NTR+QVEHP Sbjct: 260 VEEAPAPGITEEVRRDIGSRCANACVEIGYRGAGTFEFLY-ENGEFYFIEMNTRIQVEHP 318 Query: 309 VTEETAGIDLVLQQFRIANGEKLDIT-EDPTPRGHAIEFRINGEDAGRNFLPAPGPVTKF 367 VTE G+DLV +Q RIA G + ED +GHA+E RIN ED + FLP+PG V Sbjct: 319 VTEMITGVDLVKEQLRIAAGLPISFKQEDIKVKGHAMECRINAEDP-KTFLPSPGKVNHL 377 Query: 368 HPPSGPGVRVDSGVETGSVIGGQFDSMLAKLIVHGADRAEALARARRALNEFGVEGLATV 427 H P G GVR DS V G + +DSM+AKLI +G R A+ R + AL+E ++G+ T Sbjct: 378 HSPGGLGVRWDSHVYGGYTVPPHYDSMIAKLITYGDTREVAIRRMQNALSETIIDGIKTN 437 Query: 428 IPFHRAVVSDPAFIGDANGFSVH 450 IP H ++ D F G ++H Sbjct: 438 IPLHELILEDENF--QKGGTNIH 458 >2DZD-A nrPDB Length = 461 Score = 363 bits (932), Expect = e-100, Method: Compositional matrix adjust. Identities = 198/440 (45%), Positives = 273/440 (62%), Gaps = 10/440 (2%) Query: 11 RISKVLVANRGEIAVRVIRAARDAGLPSVAVYAEPDAESPHVRLADEAFALG-GQTSAES 69 RI KVLVANRGEIA+RV RA + G+ +VA+Y++ D S H ADEA+ +G G+ E+ Sbjct: 5 RIRKVLVANRGEIAIRVFRACTELGIRTVAIYSKEDVGSYHRYKADEAYLVGEGKKPIEA 64 Query: 70 YLDFAKILDAAAKSGANAIHPGYGFLAENADFAQAVIDAGLIWIGPSPQSIRDLGDKVTA 129 YLD I++ A +AIHPGYGFL+EN FA+ + G+I+IGP+ + GDKV A Sbjct: 65 YLDIEGIIEIAKAHDVDAIHPGYGFLSENIQFAKRCREEGIIFIGPNENHLDMFGDKVKA 124 Query: 130 RHIAARAQAPLVPGTPDPVKGADEVVAFAEEYGLPIAIKAAHGGGGKGMKVARTIDEIPE 189 RH A A P++PG+ PV G ++VVAFAE +G PI IKAA GGGG+GM++ R+ E+ E Sbjct: 125 RHAAVNAGIPVIPGSDGPVDGLEDVVAFAEAHGYPIIIKAALGGGGRGMRIVRSKSEVKE 184 Query: 190 LYESAVREATAAFGRGECYVERYLDKPRHVEAQVIADQHGNVVVAGTRDCSLQRRYQKLV 249 +E A EA AAFG E YVE+ ++ P+H+E Q++ D GN+V RDCS+QRR+QK+V Sbjct: 185 AFERAKSEAKAAFGSDEVYVEKLIENPKHIEVQILGDYEGNIVHLYERDCSVQRRHQKVV 244 Query: 250 EEAPAPFLTDFQRKEIHDSAKRICKEAHYHGAGTVEYLVGQDGLISFLEVNTRLQVEHPV 309 E AP+ L+D R+ I ++A ++ + Y AGTVE+LV D F+EVN R+QVEH + Sbjct: 245 EVAPSVSLSDELRQRICEAAVQLMRSVGYVNAGTVEFLVSGDEF-YFIEVNPRIQVEHTI 303 Query: 310 TEETAGIDLVLQQFRIANGEKLDITEDPTPR-------GHAIEFRINGEDAGRNFLPAPG 362 TE GID+V Q IA+G L E P+ G+AI+ R+ ED NF+P G Sbjct: 304 TEMITGIDIVQSQILIADGCSLHSHEVGIPKQEDIRINGYAIQSRVTTEDPLNNFMPDTG 363 Query: 363 PVTKFHPPSGPGVRVDSGV-ETGSVIGGQFDSMLAKLIVHGADRAEALARARRALNEFGV 421 + + G GVR+D+G G+VI +DS+L KL +A + R L EF + Sbjct: 364 KIMAYRSGGGFGVRLDAGNGFQGAVITPYYDSLLVKLSTWALTFEQAARKMLRNLREFRI 423 Query: 422 EGLATVIPFHRAVVSDPAFI 441 G+ T IPF VV P F+ Sbjct: 424 RGIKTNIPFLENVVQHPKFL 443 >3JZF-A nrPDB Length = 486 Score = 358 bits (919), Expect = 3e-99, Method: Compositional matrix adjust. Identities = 196/431 (45%), Positives = 280/431 (64%), Gaps = 4/431 (0%) Query: 12 ISKVLVANRGEIAVRVIRAARDAGLPSVAVYAEPDAESPHVRLADEAFALGGQTSAESYL 71 + K+++ANRGEIA+R++RA ++ G+ +VAV++ D + HV LADE +G S +SYL Sbjct: 23 LDKIVIANRGEIALRILRACKELGIKTVAVHSSADRDLKHVLLADETVCIGPAPSVKSYL 82 Query: 72 DFAKILDAAAKSGANAIHPGYGFLAENADFAQAVIDAGLIWIGPSPQSIRDLGDKVTARH 131 + I+ AA +GA AIHPGYGFL+ENA+FA+ V +G I+IGP ++IR +GDKV+A Sbjct: 83 NIPAIISAAEITGAVAIHPGYGFLSENANFAEQVERSGFIFIGPKAETIRLMGDKVSAIA 142 Query: 132 IAARAQAPLVPGTPDPV-KGADEVVAFAEEYGLPIAIKAAHGGGGKGMKVARTIDEIPEL 190 +A P VPG+ P+ D+ A A+ G P+ IKA+ GGGG+GM+V R E+ + Sbjct: 143 AMKKAGVPCVPGSDGPLGDDMDKNRAIAKRIGYPVIIKASGGGGGRGMRVVRGDAELAQS 202 Query: 191 YESAVREATAAFGRGECYVERYLDKPRHVEAQVIADQHGNVVVAGTRDCSLQRRYQKLVE 250 EA AAF Y+E+YL+ PRHVE QV+AD GN + RDCS+QRR+QK+VE Sbjct: 203 ISMTRAEAKAAFSNDMVYMEKYLENPRHVEIQVLADGQGNAIYLAERDCSMQRRHQKVVE 262 Query: 251 EAPAPFLTDFQRKEIHDSAKRICKEAHYHGAGTVEYLVGQDGLISFLEVNTRLQVEHPVT 310 EAPAP +T R+ I + + C + Y GAGT E+L ++G F+E+NTR+QVEHPVT Sbjct: 263 EAPAPGITPELRRYIGERCAKACVDIGYRGAGTFEFLF-ENGEFYFIEMNTRIQVEHPVT 321 Query: 311 EETAGIDLVLQQFRIANGEKLDITEDPTP-RGHAIEFRINGEDAGRNFLPAPGPVTKFHP 369 E G+DL+ +Q RIA G+ L I ++ RGHA+E RIN ED FLP+PG +T+FH Sbjct: 322 EMITGVDLIKEQLRIAAGQPLSIKQEEVHVRGHAVECRINAEDPN-TFLPSPGKITRFHA 380 Query: 370 PSGPGVRVDSGVETGSVIGGQFDSMLAKLIVHGADRAEALARARRALNEFGVEGLATVIP 429 P G GVR +S + G + +DSM+ KLI +G +R A+AR + AL E ++G+ T + Sbjct: 381 PGGFGVRWESHIYAGYTVPPYYDSMIGKLICYGENRDVAIARMKNALQELIIDGIKTNVD 440 Query: 430 FHRAVVSDPAF 440 +++D F Sbjct: 441 LQIRIMNDENF 451 >3N6R-A nrPDB Length = 681 Score = 354 bits (908), Expect = 8e-98, Method: Compositional matrix adjust. Identities = 196/451 (43%), Positives = 279/451 (61%), Gaps = 21/451 (4%) Query: 12 ISKVLVANRGEIAVRVIRAARDAGLPSVAVYAEPDAESPHVRLADEAFALGGQTSAESYL 71 +K+L+ANRGEIA RVI+ AR G+ +VA+Y++ D ++ HV++ADEA +G + +SY+ Sbjct: 2 FNKILIANRGEIACRVIKTARKMGISTVAIYSDADKQALHVQMADEAVHIGPPPANQSYI 61 Query: 72 DFAKILDAAAKSGANAIHPGYGFLAENADFAQAVIDAGLIWIGPSPQSIRDLGDKVTARH 131 K++ A +GA A+HPGYGFL+EN+ FA+A+ G+I++GP +I +GDK+T++ Sbjct: 62 VIDKVMAAIRATGAQAVHPGYGFLSENSKFAEALEAEGVIFVGPPKGAIEAMGDKITSKK 121 Query: 132 IAARAQAPLVPGTPDPVKGADEVVAFAEEYGLPIAIKAAHGGGGKGMKVARTIDEIPELY 191 IA A VPG ++ ADE V + + G P+ IKA+ GGGGKGM++A E E + Sbjct: 122 IAQEANVSTVPGYMGLIEDADEAVKISNQIGYPVMIKASAGGGGKGMRIAWNDQEAREGF 181 Query: 192 ESAVREATAAFGRGECYVERYLDKPRHVEAQVIADQHGNVVVAGTRDCSLQRRYQKLVEE 251 +S+ EA +FG ++E+++ +PRH+E QV+ D HGN + G R+CS+QRR QK+VEE Sbjct: 182 QSSKNEAANSFGDDRIFIEKFVTQPRHIEIQVLCDSHGNGIYLGERECSIQRRNQKVVEE 241 Query: 252 APAPFLTDFQRKEIHDSAKRICKEAHYHGAGTVEYLVGQDGLISFLEVNTRLQVEHPVTE 311 AP+PFL + R+ + + A + K Y AGTVE++V FLE+NTRLQVEHPVTE Sbjct: 242 APSPFLDEATRRAMGEQAVALAKAVGYASAGTVEFIVDGQKNFYFLEMNTRLQVEHPVTE 301 Query: 312 ETAGIDLVLQQFRIANGEKLDITE-DPTPRGHAIEFRINGEDAGRNFLPAPGPVTKFHPP 370 G+DLV Q R+A GE L IT+ D G AIE R+ ED R FLP+ G +T++ PP Sbjct: 302 LITGVDLVEQMIRVAAGEPLSITQGDVKLTGWAIENRLYAEDPYRGFLPSIGRLTRYRPP 361 Query: 371 ----SGP----------------GVRVDSGVETGSVIGGQFDSMLAKLIVHGADRAEALA 410 +GP VR D+GV G I +D M+AKL RA A+ Sbjct: 362 AETAAGPLLVNGKWQGDAPSGEAAVRNDTGVYEGGEISMYYDPMIAKLCTWAPTRAAAIE 421 Query: 411 RARRALNEFGVEGLATVIPFHRAVVSDPAFI 441 R AL+ F VEG+ +PF AV+ P FI Sbjct: 422 AMRIALDSFEVEGIGHNLPFLSAVMDHPKFI 452 Score = 49.7 bits (117), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 26/71 (36%), Positives = 38/71 (53%) Query: 530 SGDAVTAPMQGTVVKFAVEEGQEVVAGDLVVVLEAMKMENPVTAHKDGTITGLAVEAGAA 589 + + PM G +VK VE GQEV G + +EAMKMEN + A K G + + AG + Sbjct: 611 TSKMLLCPMPGLIVKVDVEVGQEVQEGQALCTIEAMKMENILRAEKKGVVAKINASAGNS 670 Query: 590 ITQGTVLAEIK 600 + V+ E + Sbjct: 671 LAVDDVIMEFE 681 >3OUU-A nrPDB Length = 446 Score = 344 bits (883), Expect = 6e-95, Method: Compositional matrix adjust. Identities = 183/447 (40%), Positives = 278/447 (62%), Gaps = 4/447 (0%) Query: 7 SRIARISKVLVANRGEIAVRVIRAARDAGLPSVAVYAEPDAESPHVRLADEAFALGGQTS 66 S I +L+ANRGEIA+R +R ++ G ++ VY+E D ++ +++ AD + +G S Sbjct: 1 SNAMEIKSILIANRGEIALRALRTIKEMGKKAICVYSEADKDALYLKYADASICIGKARS 60 Query: 67 AESYLDFAKILDAAAKSGANAIHPGYGFLAENADFAQAVIDAGLIWIGPSPQSIRDLGDK 126 +ESYL+ I+ AA + A+AI PGYGFL+EN +F + + +IGPS +++ + DK Sbjct: 61 SESYLNIPAIIAAAEIAEADAIFPGYGFLSENQNFVEICAKHNIKFIGPSVEAMNLMSDK 120 Query: 127 VTARHIAARAQAPLVPGTPDPVKGADEVVAFAEEYGLPIAIKAAHGGGGKGMKVARTIDE 186 A+ + RA P++PG+ + GA+ A+E G P+ +KAA GGGG+GM+V + Sbjct: 121 SKAKQVMQRAGVPVIPGSDGALAGAEAAKKLAKEIGYPVILKAAAGGGGRGMRVVENEKD 180 Query: 187 IPELYESAVREATAAFGRGECYVERYLDKPRHVEAQVIADQHGNVVVAGTRDCSLQRRYQ 246 + + Y SA EA AFG G Y+E+Y+ PRH+E QVI D GNV+ G RDCS+QRR+Q Sbjct: 181 LEKAYWSAESEAMTAFGDGTMYMEKYIQNPRHIEVQVIGDSFGNVIHVGERDCSMQRRHQ 240 Query: 247 KLVEEAPAPFLTDFQRKEIHDSAKRICKEAHYHGAGTVEYLVGQDGLISFLEVNTRLQVE 306 KL+EE+PA L + R +H++A + K Y GAGT E+LV ++ F+E+NTRLQVE Sbjct: 241 KLIEESPAILLDEKTRTRLHETAIKAAKAIGYEGAGTFEFLVDKNLDFYFIEMNTRLQVE 300 Query: 307 HPVTEETAGIDLVLQQFRIANGEKLDITEDPTPRGHAIEFRINGEDAGRNFLPAPGPVTK 366 H V+E +GID++ Q ++A G L E GH+IE RI ED+ + FLP+PG +TK Sbjct: 301 HCVSEMVSGIDIIEQMIKVAEGYALPSQESIKLNGHSIECRITAEDS-KTFLPSPGKITK 359 Query: 367 FHPPSGPGVRVDSGVETGSVIGGQFDSMLAKLIVHGADRAEALARARRALNEFGVEGLAT 426 + PP+G VR++S + +DSM+ KL+V DR +A+A+ + AL+E + G+ T Sbjct: 360 YIPPAGRNVRMESHCYQDYSVPAYYDSMIGKLVVWAEDRNKAIAKMKVALDELLISGIKT 419 Query: 427 VIPFHRAVVSDPAFIG---DANGFSVH 450 FH +++ +P FI D N + H Sbjct: 420 TKDFHLSMMENPDFINNNYDTNYLARH 446 >5H80-A nrPDB Length = 494 Score = 313 bits (801), Expect = 2e-85, Method: Compositional matrix adjust. Identities = 199/454 (43%), Positives = 272/454 (59%), Gaps = 19/454 (4%) Query: 14 KVLVANRGEIAVRVIRAARDAGLPSVAVYAEPDAESPHVRLADEAFALGGQTSAESYLDF 73 +VL+ANRGE+AVR+ RA G SVAVYA DA S HVR ADEA AL G+ +A +YLD Sbjct: 34 RVLIANRGEVAVRIERAVSALGWQSVAVYAPDDAGSLHVRRADEAVALSGRGAA-AYLDG 92 Query: 74 AKILDAAAKSGANAIHPGYGFLAENADFAQAVIDAGLIWIGPSPQSIRDLGDKVTARHIA 133 A +L A + A +HPGYGFL+ENADFA+A AGL+++GP P ++ GDK AR +A Sbjct: 93 AALLRVAQEHAATHVHPGYGFLSENADFARACAQAGLVFVGPDPDTLDLFGDKSRARGLA 152 Query: 134 ARAQAPLVPGTPDPVKGADEVVAFAE-EYGLPIAIKAAHGGGGKGMKVARTIDEIPELYE 192 R P++PGT D +E AF + + G P+ +KA GGGG+GM+V R ++ +E Sbjct: 153 QRLGVPVIPGT-DGATTLEEAAAFMQAQGGAPVMLKACSGGGGRGMRVVRQAGDLAAAFE 211 Query: 193 SAVREATAAFGRGECYVERYLDKPRHVEAQVIADQHGNVVVAGTRDCSLQRRYQKLVEEA 252 A REA A G+G+ Y ER +++ RH+E QV D +V RDC++QRR+QKL+E A Sbjct: 212 QASREARLAVGQGDLYAERLIERARHIEVQVAGDGQ-SVTHLWERDCTVQRRHQKLLEFA 270 Query: 253 PAPFLTDFQRKEIHDSAKRICKEAHYHGAGTVEYLVGQDGLISFLEVNTRLQVEHPVTEE 312 PAP L R + +A ++ +E Y GT E+LV G F+E N RLQVEH VTEE Sbjct: 271 PAPHLPQAVRTALIGAALQLAQEVKYRCLGTFEFLVTPGGDFYFIEANPRLQVEHTVTEE 330 Query: 313 TAGIDLVLQQFRIANGEKLD---ITEDPT----PRGHAIEFRINGEDAGRN--FLPAPGP 363 G DLV Q R+A GE L + P P G A++ R+N E G + G Sbjct: 331 WCGTDLVTAQLRLAAGETLTAVGLATQPADAAPPPGQAVQARVNMETLGADGQVHVGGGQ 390 Query: 364 VTKFHPPSGPGVRVDSGVETGSVIGGQFDSMLAKLIVHGADRAE--ALARARRALNEFGV 421 V F PP GPGVRVD+ V TG Q+D++LAK++VH D A L +A AL+EF + Sbjct: 391 VQTFTPPGGPGVRVDTFVTTGLTPSPQYDALLAKVVVHRRDAALPGLLRQAATALSEFQI 450 Query: 422 EGLATVIPFHRAVVSDPAFIGDANGFSVHTRWIE 455 G++T + F +A++ P D + + T W++ Sbjct: 451 AGVSTNLAFLQALLHHP----DVQHYELSTHWLD 480 >5KS8-A nrPDB Length = 405 Score = 220 bits (561), Expect = 1e-57, Method: Compositional matrix adjust. Identities = 106/227 (46%), Positives = 150/227 (66%), Gaps = 1/227 (0%) Query: 215 KPRHVEAQVIADQHGNVVVAGTRDCSLQRRYQKLVEEAPAPFLTDFQRKEIHDSAKRICK 274 PRH+E QV+AD HGNV+ RDCS+QRR QKL+E AP+P L+ QR+ I + A + K Sbjct: 137 NPRHIEVQVLADSHGNVIHLFERDCSIQRRNQKLIEIAPSPQLSKAQREYIGNLAVKAAK 196 Query: 275 EAHYHGAGTVEYLVGQDGLISFLEVNTRLQVEHPVTEETAGIDLVLQQFRIANGEKLDIT 334 Y AGTVE+L+ D F+E+NTRLQVEH VTE+ GID+V +Q R+A+G++L Sbjct: 197 AVGYKNAGTVEFLLDSDNNFYFMEMNTRLQVEHTVTEQITGIDIVQEQIRVADGQRLQYK 256 Query: 335 EDPTP-RGHAIEFRINGEDAGRNFLPAPGPVTKFHPPSGPGVRVDSGVETGSVIGGQFDS 393 + RG A+EFRIN ED +FLP+ G +T+++ P GPG+R+D+ + +G VI +DS Sbjct: 257 QSEVQYRGFAMEFRINAEDPKNDFLPSFGKITRYYAPGGPGIRMDAAMYSGYVIPPYYDS 316 Query: 394 MLAKLIVHGADRAEALARARRALNEFGVEGLATVIPFHRAVVSDPAF 440 M AKL V + + R RRALN+ V G+ T IP+++ ++ P F Sbjct: 317 MCAKLTVWALNWESVVERGRRALNDTVVYGVKTTIPYYQEILKHPDF 363 Score = 118 bits (295), Expect = 8e-27, Method: Compositional matrix adjust. Identities = 58/130 (44%), Positives = 85/130 (65%), Gaps = 1/130 (0%) Query: 12 ISKVLVANRGEIAVRVIRAARDAGLPSVAVYAEPDAESPHVRLADEAFALGGQTSAESYL 71 I K+L+ANRGEIAVR++RA + G+ SVA+Y++ D + HV+ ADEA+ +G YL Sbjct: 2 IKKILIANRGEIAVRIVRACSEMGIKSVAIYSDADRHALHVKKADEAYNIGSD-PVLGYL 60 Query: 72 DFAKILDAAAKSGANAIHPGYGFLAENADFAQAVIDAGLIWIGPSPQSIRDLGDKVTARH 131 + I++ A SG +A+HPGYGFL+EN + A+ G+ +IGP + IR +GDK+ AR Sbjct: 61 NAHNIVNLAVASGCDALHPGYGFLSENPELAEICARRGIKFIGPDAKVIRQMGDKIQART 120 Query: 132 IAARAQAPLV 141 +A P V Sbjct: 121 AMIKAGIPCV 130 >2YL2-A nrPDB Length = 540 Score = 216 bits (551), Expect = 2e-56, Method: Compositional matrix adjust. Identities = 147/472 (31%), Positives = 216/472 (45%), Gaps = 64/472 (13%) Query: 12 ISKVLVANRGEIAVRVIRAARDAGLP--------SVAVYAEPD---AESPHVRLADEAFA 60 I KVL+AN G AV+ +R+ R V P+ A + ++++AD Sbjct: 41 IEKVLIANNGIAAVKCMRSIRRWSYEMFRNERAIRFVVMVTPEDLKANAEYIKMADHYVP 100 Query: 61 LGGQTSAESYLDFAKILDAAAKSGANAIHPGYGFLAENADFAQAVIDAGLIWIGPSPQSI 120 + G + +Y + ILD A + A+ G+G +EN + ++ G+ ++GP Q++ Sbjct: 101 VPGGPNNNNYANVELILDIAKRIPVQAVWAGWGHASENPKLPELLLKNGIAFMGPPSQAM 160 Query: 121 RDLGDKVTARHIAARAQAPLVPGT--------------------------PDPVKGADEV 154 LGDK+ + +A A P +P + VK D+ Sbjct: 161 WALGDKIASSIVAQTAGIPTLPWSGSGLRVDWQENDFSKRILNVPQELYEKGYVKDVDDG 220 Query: 155 VAFAEEYGLPIAIKAAHGGGGKGMKVARTIDEIPELYESAVREATAAFGRGECYVERYLD 214 + AEE G P+ IKA+ GGGGKG++ D+ P L+ R+ A +V R Sbjct: 221 LQAAEEVGYPVMIKASEGGGGKGIRKVNNADDFPNLF----RQVQAEVPGSPIFVMRLAK 276 Query: 215 KPRHVEAQVIADQHGNVVVAGTRDCSLQRRYQKLVEEAPAPFLTDFQRKEIHDSAKRICK 274 + RH+E Q++ADQ+GN + RDCS+QRR+QK++EEAPA T + + A ++ K Sbjct: 277 QSRHLEVQILADQYGNAISLFGRDCSVQRRHQKIIEEAPATIATPAVFEHMEQCAVKLAK 336 Query: 275 EAHYHGAGTVEYLVGQDGLISFLEVNTRLQVEHPVTEETAGIDLVLQQFRIANGEKLDIT 334 Y AGTVEYL QDG FLE+N RLQVEHP TE A ++L Q +IA G L Sbjct: 337 MVGYVSAGTVEYLYSQDGSFYFLELNPRLQVEHPCTEMVADVNLPAAQLQIAMGIPLYRI 396 Query: 335 ED-----------------------PTPRGHAIEFRINGEDAGRNFLPAPGPVTKFHPPS 371 +D P PRGH I RI E+ F P+ G V + + S Sbjct: 397 KDIRMMYGVSPWGDSPIDFEDSAHVPCPRGHVIAARITSENPDEGFKPSSGTVQELNFRS 456 Query: 372 GPGVRVDSGVETGSVIGGQFDSMLAKLIVHGADRAEALARARRALNEFGVEG 423 V V + DS G +R EA++ AL E + G Sbjct: 457 NKNVWGYFSVAAAGGLHEFADSQFGHCFSWGENREEAISNMVVALKELSIRG 508 >3JRW-A nrPDB Length = 587 Score = 204 bits (520), Expect = 6e-53, Method: Compositional matrix adjust. Identities = 156/517 (30%), Positives = 238/517 (46%), Gaps = 82/517 (15%) Query: 6 GSRIARISKVLVANRGEIAVRVIRAARDAGLP--------SVAVYAEPD---AESPHVRL 54 G R+ I KVL+AN G AV+ +R+ R V P+ A + ++++ Sbjct: 52 GDRV--IEKVLIANNGIAAVKCMRSIRRWAYEMFRNERAIRFVVMVTPEDLKANAEYIKM 109 Query: 55 ADEAFALGGQTSAESYLDFAKILDAAAKSGANAIHPGYGFLAENADFAQAVIDAGLIWIG 114 AD + G + +Y + I+D A + A+ G+G +EN + + G+ ++G Sbjct: 110 ADHYVPVPGGPNNNNYANVELIVDIAKRIPVQAVWAGWGHASENPKLPELLCKNGVAFLG 169 Query: 115 PSPQSIRDLGDKVTARHIAARAQAPLVPGT---------------------PDP------ 147 P +++ LGDK+ + +A Q P +P + P+ Sbjct: 170 PPSEAMWALGDKIASTVVAQTLQVPTLPWSGSGLTVEWTEDDLQQGKRISVPEDVYDKGC 229 Query: 148 VKGADEVVAFAEEYGLPIAIKAAHGGGGKGMKVARTIDEIPELYESAVREATAAFGRGEC 207 VK DE + AE G P+ IKA+ GGGGKG++ A + ++ P L+ R+ + Sbjct: 230 VKDVDEGLEAAERIGFPLMIKASEGGGGKGIRKAESAEDFPILF----RQVQSEIPGSPI 285 Query: 208 YVERYLDKPRHVEAQVIADQHGNVVVAGTRDCSLQRRYQKLVEEAPAPF--LTDFQRKEI 265 ++ + RH+E Q++ADQ+GN V RDCS+QRR+QK+VEEAPA L F+ E Sbjct: 286 FLMKLAQHARHLEVQILADQYGNAVSLFGRDCSIQRRHQKIVEEAPATIAPLAIFEFME- 344 Query: 266 HDSAKRICKEAHYHGAGTVEYLVGQDGLISFLEVNTRLQVEHPVTEETAGIDLVLQQFRI 325 A R+ K Y AGTVEYL QDG FLE+N RLQVEHP TE A ++L Q +I Sbjct: 345 -QCAIRLAKTVGYVSAGTVEYLYSQDGSFHFLELNPRLQVEHPCTEMIADVNLPAAQLQI 403 Query: 326 ANGEKLDITED-----------------------PTPRGHAIEFRINGEDAGRNFLPAPG 362 A G L +D P RGH I RI E+ F P+ G Sbjct: 404 AMGVPLHRLKDIRLLYGESPWGVTPISFETPSNPPLARGHVIAARITSENPDEGFKPSSG 463 Query: 363 PVTKFHPPSGPGVRVDSGVETGSVIGG--QF-DSMLAKLIVHGADRAEALARARRALNEF 419 V + + S V G + + GG +F DS G +R EA++ AL E Sbjct: 464 TVQELNFRSSKNVW---GYFSVAATGGLHEFADSQFGHCFSWGENREEAISNMVVALKEL 520 Query: 420 GVEG-LATVIPFHRAVVSDPAFIGDANGFSVHTRWIE 455 + G T + + ++ +F + + T W++ Sbjct: 521 SIRGDFRTTVEYLINLLETESFQNN----DIDTGWLD 553 >1W93-A nrPDB Length = 553 Score = 194 bits (493), Expect = 9e-50, Method: Compositional matrix adjust. Identities = 147/491 (29%), Positives = 225/491 (45%), Gaps = 74/491 (15%) Query: 1 MASHAGSRIARISKVLVANRGEIAVRVIRAAR---------DAGLPSVAVYAEPDAES-- 49 + SH G + ISK+L+AN G AV+ IR+ R D + VA+ D E+ Sbjct: 37 VKSHGGHTV--ISKILIANNGIAAVKEIRSVRKWAYETFGDDRTVQFVAMATPEDLEANA 94 Query: 50 PHVRLADEAFALGGQTSAESYLDFAKILDAAAKSGANAIHPGYGFLAENADFAQAVIDAG 109 ++R+AD+ + G T+ +Y + I+D A ++ +A+ G+G +EN + + + Sbjct: 95 EYIRMADQYIEVPGGTNNNNYANVDLIVDIAERADVDAVWAGWGHASENPLLPEKLSQSK 154 Query: 110 --LIWIGPSPQSIRDLGDKVTARHIAARAQAPLVP--GTPDPVKGADEVVAF-------- 157 +I+IGP ++R LGDK+++ +A A+ P +P GT DE Sbjct: 155 RKVIFIGPPGNAMRSLGDKISSTIVAQSAKVPCIPWSGTGVDTVHVDEKTGLVSVDDDIY 214 Query: 158 --------------AEEYGLPIAIKAAHGGGGKGMKVARTIDEIPELYESAVREATAAFG 203 A+ G P+ IKA+ GGGGKG++ ++ LY A E + Sbjct: 215 QKGCCTSPEDGLQKAKRIGFPVMIKASEGGGGKGIRQVEREEDFIALYHQAANEIPGS-- 272 Query: 204 RGECYVERYLDKPRHVEAQVIADQHGNVVVAGTRDCSLQRRYQKLVEEAPAPFLTDFQRK 263 ++ + + RH+E Q++ADQ+G + RDCS+QRR+QK++EEAP Sbjct: 273 --PIFIMKLAGRARHLEVQLLADQYGTNISLFGRDCSVQRRHQKIIEEAPVTIAKAETFH 330 Query: 264 EIHDSAKRICKEAHYHGAGTVEYLVGQ-DGLISFLEVNTRLQVEHPVTEETAGIDLVLQQ 322 E+ +A R+ K Y AGTVEYL DG FLE+N RLQVEHP TE +G++L Q Sbjct: 331 EMEKAAVRLGKLVGYVSAGTVEYLYSHDDGKFYFLELNPRLQVEHPTTEMVSGVNLPAAQ 390 Query: 323 FRIANG--------------------EKLDI---TED-------PTPRGHAIEFRINGED 352 +IA G ++D T+D P P+GH RI ED Sbjct: 391 LQIAMGIPMHRISDIRTLYGMNPHSASEIDFEFKTQDATKKQRRPIPKGHCTACRITSED 450 Query: 353 AGRNFLPAPGPVTKFHPPSGPGVRVDSGVETGSVIGGQFDSMLAKLIVHGADRAEALARA 412 F P+ G + + + S V V I DS + G +R + Sbjct: 451 PNDGFKPSGGTLHELNFRSSSNVWGYFSVGNNGNIHSFSDSQFGHIFAFGENRQASRKHM 510 Query: 413 RRALNEFGVEG 423 AL E + G Sbjct: 511 VVALKELSIRG 521 >5KS8-C nrPDB Length = 617 Score = 67.0 bits (162), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 56/162 (34%), Positives = 76/162 (46%), Gaps = 20/162 (12%) Query: 450 HTRWIETEWNNTI--EPF----TDGEPLDEDARPRQKVVVEIDGRRVEVSLPADLALSNG 503 H+R+ TE+N T+ E F T E+ RP V +DG EV + + Sbjct: 463 HSRFAPTEFNVTLHGETFHIKLTGSGHHGEEQRP---FYVSVDGVTEEVVVEILNEIEVS 519 Query: 504 GGCDPVGVIRRKPKP-----RKRGAHTGAAASGDAVTAPMQGTVVKFAVEEGQEVVAGDL 558 GG G +RK R R H G VT M GT+V V G +V AGD Sbjct: 520 GGGQSSGEAKRKASSAASSGRPRPTHAGC------VTTAMPGTIVDVKVNVGDKVSAGDA 573 Query: 559 VVVLEAMKMENPVTAHKDGTITGLAVEAGAAITQGTVLAEIK 600 V+V+EAMKMEN + A K G + + V+ G ++T L EI+ Sbjct: 574 VLVIEAMKMENEIQASKSGVVVAINVKKGDSVTPDEALLEIQ 615 >2CQY-A nrPDB Length = 108 Score = 65.5 bits (158), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 37/96 (38%), Positives = 61/96 (63%) Query: 124 GDKVTARHIAARAQAPLVPGTPDPVKGADEVVAFAEEYGLPIAIKAAHGGGGKGMKVART 183 GDK+ ++ +A +A+ +PG VK A+E V A E G P+ IKA+ GGGGKGM++A Sbjct: 7 GDKIESKLLAKKAEVNTIPGFDGVVKDAEEAVRIAREIGYPVMIKASAGGGGKGMRIAWD 66 Query: 184 IDEIPELYESAVREATAAFGRGECYVERYLDKPRHV 219 +E + + + +EA ++FG +E+++D PRH+ Sbjct: 67 DEETRDGFRLSSQEAASSFGDDRLLIEKFIDNPRHI 102 >4HR7-B nrPDB Length = 176 Score = 47.4 bits (111), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 29/72 (40%), Positives = 39/72 (54%), Gaps = 7/72 (9%) Query: 523 AHTGAAASGDAVTAPMQGTV-------VKFAVEEGQEVVAGDLVVVLEAMKMENPVTAHK 575 A A SG V +PM GT K +E GQ+V GD + ++EAMKM N + A K Sbjct: 92 APAAAEISGHIVRSPMVGTFYRTPSPDAKAFIEVGQKVNVGDTLCIVEAMKMMNQIEADK 151 Query: 576 DGTITGLAVEAG 587 GT+ + VE+G Sbjct: 152 SGTVKAILVESG 163 >1A6X-A nrPDB Length = 87 Score = 47.4 bits (111), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 29/72 (40%), Positives = 39/72 (54%), Gaps = 7/72 (9%) Query: 523 AHTGAAASGDAVTAPMQGTV-------VKFAVEEGQEVVAGDLVVVLEAMKMENPVTAHK 575 A A SG V +PM GT K +E GQ+V GD + ++EAMKM N + A K Sbjct: 3 APAAAEISGHIVRSPMVGTFYRTPSPDAKAFIEVGQKVNVGDTLCIVEAMKMMNQIEADK 62 Query: 576 DGTITGLAVEAG 587 GT+ + VE+G Sbjct: 63 SGTVKAILVESG 74 >5CSA-A nrPDB Length = 932 Score = 43.5 bits (101), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 21/62 (33%), Positives = 35/62 (56%), Gaps = 1/62 (1%) Query: 536 APMQGTVVKFAVEEGQEVVAGDLVVVLEAMKMENPVTAHKDGTITGLAVEAGAAITQGTV 595 P G +VKF VE G+ ++ G +E MKM+ P+ + ++G I L + G+ I G + Sbjct: 137 TPSPGKLVKFLVENGEHIIKGQPYAEIEVMKMQMPLVSQENG-IVQLLKQPGSTIVAGDI 195 Query: 596 LA 597 +A Sbjct: 196 MA 197 >6DGI-A nrPDB Length = 337 Score = 41.6 bits (96), Expect = 0.001, Method: Compositional matrix adjust. Identities = 56/228 (24%), Positives = 92/228 (40%), Gaps = 31/228 (13%) Query: 92 YGFLAENADFAQAVIDAGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVP------GTP 145 +GF E D + AG+ ++G P++ + +K+T++ P P TP Sbjct: 86 HGFPGETGDIQSMLELAGIPYLGCGPEASANSFNKITSKLWYDALDIPNTPYLFLTQNTP 145 Query: 146 DPVKGADEVVAFAEEYGLPIAIKAAHGGGGKGMKVARTIDEIPELYESAVREATAAFGRG 205 + A + AF +G I +KAA G G T D+I E AAFG Sbjct: 146 SSIDKAKQ--AFG-HWG-SIFVKAARQGSSVGCYKVTTEDQIAPAIE-------AAFGFS 194 Query: 206 ECYVERYLDKPRHVEA-------QVIADQHGNVVVAGTRDCSLQRRYQ-----KLVEEAP 253 E + KPR +E ++ + G V+ S + +Y + V EA Sbjct: 195 EQVLVEQAVKPRELEVSAYEMNGKLYISKPGEVIAPEGTFYSYEEKYSANSHARTVLEAE 254 Query: 254 APFLTDFQRKEIHDSAKRICKEAHYHGAGTVEYLVGQDGLISFLEVNT 301 LT+ ++ I A+R+ +++ + Q+G I EVNT Sbjct: 255 N--LTEKHKELIQTYAERVFIHMKLRHLSRIDFFLTQEGQIYLNEVNT 300 >3MJF-A nrPDB Length = 431 Score = 35.8 bits (81), Expect = 0.050, Method: Compositional matrix adjust. Identities = 57/214 (26%), Positives = 83/214 (38%), Gaps = 27/214 (12%) Query: 108 AGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPGTPDPVKGADEVVAFAEEYGLPIAI 167 AGL GP+ + + G K + AR P + +A+ + G PI I Sbjct: 90 AGLAIFGPTQAAAQLEGSKAFTKDFLARHNIP--SAEYQNFTDVEAALAYVRQKGAPIVI 147 Query: 168 KAAHGGGGKGMKVARTIDEIPELYESAVREATA--AFGRG--ECYVERYLDKPRHVEAQV 223 KA GKG+ VA T +E E+AV + A AFG VE +LD EA Sbjct: 148 KADGLAAGKGVIVAMTQEEA----ETAVNDMLAGNAFGDAGHRIVVEEFLDGE---EASF 200 Query: 224 IADQHG-NVVVAGTR-------DCSLQRRYQKLVEEAPAPFLTDFQRKEIHD-----SAK 270 I G NV+ T D + +PAP +TD + + D + + Sbjct: 201 IVMVDGENVLPMATSQDHKRVGDGDTGPNTGGMGAYSPAPVVTDDVHQRVMDQVIWPTVR 260 Query: 271 RICKEAH-YHGAGTVEYLVGQDGLISFLEVNTRL 303 + E + Y G ++ DG +E N R Sbjct: 261 GMAAEGNIYTGFLYAGLMISADGQPKVIEFNCRF 294 >2IP4-A nrPDB Length = 417 Score = 35.8 bits (81), Expect = 0.050, Method: Compositional matrix adjust. Identities = 36/140 (25%), Positives = 61/140 (43%), Gaps = 13/140 (9%) Query: 98 NADFAQAVIDA----GLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPGTPDPVKGADE 153 A + + DA GL+ GP+ ++ G K A+ + R P + E Sbjct: 70 EAPLVEGIADAFQARGLLLFGPTQKAAMIEGSKAFAKGLMERYGIPTA--RYRVFREPLE 127 Query: 154 VVAFAEEYGLPIAIKAAHGGGGKGMKVARTIDEIPELYESAVREATAAFGRGECYVERYL 213 +A+ EE G+P+ +K + GKG+ VA + + + + + A GE VE YL Sbjct: 128 ALAYLEEVGVPVVVKDSGLAAGKGVTVAFDLHQAKQAVANILNRAEG----GEVVVEEYL 183 Query: 214 DKPRHVEAQVIADQHGNVVV 233 + EA V+A G ++ Sbjct: 184 EGE---EATVLALTDGETIL 200 >4MAM-A nrPDB Length = 373 Score = 35.8 bits (81), Expect = 0.062, Method: Compositional matrix adjust. Identities = 39/139 (28%), Positives = 63/139 (45%), Gaps = 14/139 (10%) Query: 159 EEYGLPIAIKAAH-GGGGKGMKVARTIDEIPELYESAVREATAAFGRGECYVERYLDKPR 217 +++GLP +K G GKG V R+ ++I + ++ +++A G Y E ++D Sbjct: 129 DDHGLPAILKTRRFGYDGKGQFVIRSQEDITKAWD-VLKDAP----DGLIY-EAFVDFDY 182 Query: 218 HVEAQVIADQHGNVVVAGTRDCSLQRRYQK--LVEEAPAPFLTDFQRKEIHDSAKRICKE 275 V AD GN+ L R K ++ E+ APF ++ AK + KE Sbjct: 183 EVSQICTADLKGNIAFY-----PLARNTHKQGIIVESEAPFENVVLAEKAQQIAKILVKE 237 Query: 276 AHYHGAGTVEYLVGQDGLI 294 Y G +E+ V D LI Sbjct: 238 FAYVGTLAIEFFVKGDELI 256 >1GSO-A nrPDB Length = 431 Score = 35.4 bits (80), Expect = 0.074, Method: Compositional matrix adjust. Identities = 61/227 (26%), Positives = 91/227 (40%), Gaps = 31/227 (13%) Query: 99 ADFAQAVID----AGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPGTPDPVKGADEV 154 A + V+D AGL GP+ + + G K + AR + P + Sbjct: 76 APLVKGVVDTFRAAGLKIFGPTAGAAQLEGSKAFTKDFLARHKIP--TAEYQNFTEVEPA 133 Query: 155 VAFAEEYGLPIAIKAAHGGGGKGMKVARTIDEIPELYESAVREATA--AFGRG--ECYVE 210 +A+ E G PI IKA GKG+ VA T++E E+AV + A AFG +E Sbjct: 134 LAYLREKGAPIVIKADGLAAGKGVIVAMTLEEA----EAAVHDMLAGNAFGDAGHRIVIE 189 Query: 211 RYLDKPRHVEAQVIADQHGNVVVAGTRDCSLQRRYQK--------LVEEAPAPFLTD--F 260 +LD EA I G V+ +R K + +PAP +TD Sbjct: 190 EFLDGE---EASFIVMVDGEHVLPMATSQDHKRVGDKDTGPNTGGMGAYSPAPVVTDDVH 246 Query: 261 QR---KEIHDSAKRICKEAH-YHGAGTVEYLVGQDGLISFLEVNTRL 303 QR + I + K + E + Y G ++ + G +E N R Sbjct: 247 QRTMERIIWPTVKGMAAEGNTYTGFLYAGLMIDKQGNPKVIEFNCRF 293 >5BPF-A nrPDB Length = 306 Score = 35.0 bits (79), Expect = 0.094, Method: Compositional matrix adjust. Identities = 41/171 (23%), Positives = 63/171 (36%), Gaps = 46/171 (26%) Query: 152 DEVVAFAEEYGLPIAIKAAHGGGGKGMKVARTIDEIPELYESAVREATAAFGR-GECYVE 210 +E+VA + GLP+ +K +H G GM +D EL ++ V AF + +E Sbjct: 128 EELVACVAKLGLPLIVKPSHEGSSVGMS---KVDHASELQKALVE----AFQHDSDVLIE 180 Query: 211 RYLDKPRHVEAQVIADQHGNVVVAGTRDCSLQRRYQKLVEEAPAPFLTDFQRKEIHDSAK 270 ++L P A + G+ V+ R P D+ K + D + Sbjct: 181 KWLSGPEFTVAIL-----GDEVLPSIRI-------------QPPGVFYDYDAKYLSDKTQ 222 Query: 271 RIC---------------KEAHYH-----GAGTVEYLVGQDGLISFLEVNT 301 C YH G G V+ + +DG LEVNT Sbjct: 223 YFCPSGLSDESEQQLAALALQAYHALDCSGWGRVDVMQDRDGHFYLLEVNT 273 >2XD4-A nrPDB Length = 422 Score = 35.0 bits (79), Expect = 0.096, Method: Compositional matrix adjust. Identities = 36/131 (27%), Positives = 48/131 (36%), Gaps = 12/131 (9%) Query: 108 AGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPGTPDPVKGADEVVAFAEEYGLPIAI 167 AGL GPS + G K A+ + + P + DE A+ +E G PI I Sbjct: 85 AGLHVFGPSKAAAIIEGSKQFAKDLMKKYDIP--TAEYETFTSFDEAKAYVQEKGAPIVI 142 Query: 168 KAAHGGGGKGMKVARTIDEIPELYESAVREATAAFGRGECYVERYLD----------KPR 217 KA GKG+ VA T +E + + +E YL K Sbjct: 143 KADGLAAGKGVTVAMTEEEAIACLHDFLEDEKFGDASASVVIEEYLSGEEFSLMAFVKGE 202 Query: 218 HVEAQVIADQH 228 V VIA H Sbjct: 203 KVYPMVIAQDH 213 >2YS6-A nrPDB Length = 451 Score = 35.0 bits (79), Expect = 0.10, Method: Compositional matrix adjust. Identities = 34/123 (27%), Positives = 55/123 (44%), Gaps = 10/123 (8%) Query: 98 NADFAQAVID----AGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPGTPD--PVKGA 151 A A ++D GL GPS ++ G K A+ + + P T D Sbjct: 92 EAPLASGIVDRFMAEGLRIFGPSQRAALIEGSKAFAKELMKKYGIP----TADHAAFTSY 147 Query: 152 DEVVAFAEEYGLPIAIKAAHGGGGKGMKVARTIDEIPELYESAVREATAAFGRGECYVER 211 +E A+ E+ G PI IKA GKG+ VA+T++E ++A+ + + +E Sbjct: 148 EEAKAYIEQKGAPIVIKADGLAAGKGVTVAQTVEEALAAAKAALVDGQFGTAGSQVVIEE 207 Query: 212 YLD 214 YL+ Sbjct: 208 YLE 210 >3AX6-A nrPDB Length = 380 Score = 33.5 bits (75), Expect = 0.24, Method: Compositional matrix adjust. Identities = 40/194 (20%), Positives = 78/194 (40%), Gaps = 32/194 (16%) Query: 40 AVYAEPDAESPHVRLADEAFALGGQTSAESYLDFAKILDAAAKSGANAIHPGYGFLAENA 99 + +P SP ++ADE G + D +I D S Y + Sbjct: 27 VIVLDPTPRSPAGQVADEQIVAG-------FFDSERIEDLVKGSDVTT----YDLEHIDV 75 Query: 100 DFAQAVIDAGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPGTPDP-VKGADEVVAFA 158 + + + G I PSP ++ + DK + + G P P K ++ + Sbjct: 76 QTLKKLYNEGY-KIHPSPYTLEIIQDKFVQKEFLKKN------GIPVPEYKLVKDLESDV 128 Query: 159 EEYGLPIAIKAAHGG-GGKGMKVARTIDEIPELYESAVREATAAFGRGECYVERYLDKPR 217 E+G P+ KA GG G+G+ + + ++ E+A++ GE Y+E +++ + Sbjct: 129 REFGFPVVQKARKGGYDGRGVFIIKNEKDL----ENAIK--------GETYLEEFVEIEK 176 Query: 218 HVEAQVIADQHGNV 231 + V ++ G + Sbjct: 177 ELAVMVARNEKGEI 190 >1OBB-A nrPDB Length = 480 Score = 32.7 bits (73), Expect = 0.48, Method: Compositional matrix adjust. Identities = 24/66 (36%), Positives = 33/66 (50%), Gaps = 2/66 (3%) Query: 48 ESPHVRLADEAFALGGQTSAESY-LDFAKILDAAAKSGANAIHPGYGFLAEN-ADFAQAV 105 E+P VRL+D LG S + + L+ KILD KSG I L +N A F + Sbjct: 316 ENPSVRLSDLGSVLGKDLSEKQFVLEVEKILDPERKSGEQHIPFIDALLNDNKARFVVNI 375 Query: 106 IDAGLI 111 + G+I Sbjct: 376 PNKGII 381 >3AW8-A nrPDB Length = 369 Score = 32.3 bits (72), Expect = 0.62, Method: Compositional matrix adjust. Identities = 55/217 (25%), Positives = 85/217 (39%), Gaps = 21/217 (9%) Query: 141 VPGTP-DPVKGADEVVAFAEEYGLPIAIKAAHGG-GGKGMKVARTIDEIPELYESAVREA 198 VP P PV G +++ + GLP +K GG GKG + RT +E EA Sbjct: 109 VPTPPFHPVDGPEDLEEGLKRVGLPALLKTRRGGYDGKGQALVRTEEE--------ALEA 160 Query: 199 TAAFGRGECYVERYLDKPRHVEAQVIADQHGNVVVAGTRDCSLQRRYQKLVE--EAPAPF 256 A G +E ++ R V + + G V + R + ++ APAP Sbjct: 161 LKALGGRGLILEGFVPFDREVSLLAVRGRTGEVAFYPLVE---NRHWGGILRLSLAPAPG 217 Query: 257 LTDFQRKEIHDSAKRICKEAHYHGAGTVEYL-VGQDGLISFLEVNTRLQVEHPVTEETAG 315 ++ +K+ A R + Y G +E+ VG++ + F E+ R+ T E A Sbjct: 218 ASEALQKKAEAYALRAMEALDYVGVLALEFFQVGEE--LLFNEMAPRVHNSGHWTIEGAE 275 Query: 316 IDLVLQQFRIANGEKLDITEDPTPRGHAIEFRINGED 352 R G L T PRG + + GE Sbjct: 276 TSQFENHLRAVLGLPLGST---APRGQSAMVNLIGEK 309 >3LWB-A nrPDB Length = 373 Score = 32.3 bits (72), Expect = 0.66, Method: Compositional matrix adjust. Identities = 42/157 (26%), Positives = 59/157 (37%), Gaps = 20/157 (12%) Query: 158 AEEYGLPIAIKAAHGGGGKGMKVARTIDEIPELYESAVR-------EATAAFGRGECYVE 210 E GLP+ +K A GG G+ + D++P A R EA + EC V Sbjct: 184 CERLGLPVFVKPARGGSSIGVSRVSSWDQLPAAVARARRHDPKVIVEAAISGRELECGV- 242 Query: 211 RYLDKPRHVEAQVIADQHGNVVVAGTRD-----CSLQRRYQKLVEEAPAPFLTDFQRKE- 264 L+ P + + A G + VAG R +Y E P D Q E Sbjct: 243 --LEMP---DGTLEASTLGEIRVAGVRGREDSFYDFATKYLDDAAELDVPAKVDDQVAEA 297 Query: 265 IHDSAKRICKEAHYHGAGTVEYLVGQDGLISFLEVNT 301 I A R G V++ + DG + E+NT Sbjct: 298 IRQLAIRAFAAIDCRGLARVDFFLTDDGPV-INEINT 333 >5LIE-A nrPDB Length = 414 Score = 32.3 bits (72), Expect = 0.68, Method: Compositional matrix adjust. Identities = 22/67 (32%), Positives = 30/67 (44%), Gaps = 10/67 (14%) Query: 65 TSAESYLDFAKILDAAAKSGANAIHPGYGFLAENADFAQAV----------IDAGLIWIG 114 + AE YL F + A A++ N+I G LAEN D Q + I+ + W Sbjct: 239 SDAELYLFFHLLFSAGAETTRNSIAGGLLALAENPDQLQTLRSDFELLPTAIEEIVRWTS 298 Query: 115 PSPQSIR 121 PSP R Sbjct: 299 PSPSKRR 305 >4IZO-A nrPDB Length = 419 Score = 31.6 bits (70), Expect = 0.93, Method: Compositional matrix adjust. Identities = 63/298 (21%), Positives = 103/298 (34%), Gaps = 24/298 (8%) Query: 44 EPDAESPHVRLADEAFALGGQTSAESYLDFAKILDAAAKSGANAIHPGYGFLAENADFAQ 103 +PD SP +AD+ A + + A++ DA + N FLA++ Sbjct: 65 DPDPTSPAGAVADKHLRAAYDDEA-ALAELAQLCDAVSTEFENVPAASLDFLAQS----- 118 Query: 104 AVIDAGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPGTP-DPVKGADEVVAFAEEYG 162 ++ P+ + + D++ + A + P+ P + + Sbjct: 119 -------TFVAPAGRCVAIAQDRIAEKRFIAASGVPVAPHVVIESAAQLAALADADLAAV 171 Query: 163 LPIAIKAAH-GGGGKGMKVARTIDEIPELYESAVREATAAFGRGECYVERYLDKPRHVEA 221 LP +K A G GKG T E R+A + G C +E+ L V A Sbjct: 172 LPGILKTARLGYDGKGQVRVATAQE--------ARDAYGSLGGVPCVLEKRLPLKYEVSA 223 Query: 222 QVIADQHGNVVVAGTRDCSLQRRYQKLVEEAPAPFLTDFQRKEIHDSAKRICKEAHYHGA 281 + +G V + L PAP +D ++ +A RI Y G Sbjct: 224 LIARGANGASAVFPLAQNTHHGGILSL-SVVPAPAASDALVRDAQQAAARIADSLDYVGV 282 Query: 282 GTVEYLVGQDGLISFLEVNTRLQVEHPVTEETAGIDLVLQQFRIANGEKLDITEDPTP 339 VE+ V +DG + E+ R T + QQ R L T +P Sbjct: 283 LCVEFFVLEDGSLVANEMAPRPHNSGHYTVDACETSQFEQQVRAMTRLPLGSTRQHSP 340 >1ZY8-K nrPDB Length = 229 Score = 31.6 bits (70), Expect = 0.98, Method: Compositional matrix adjust. Identities = 17/50 (34%), Positives = 28/50 (56%) Query: 539 QGTVVKFAVEEGQEVVAGDLVVVLEAMKMENPVTAHKDGTITGLAVEAGA 588 +G +VK+ +EG+ V AGD + +E K + A DG + + VE G+ Sbjct: 17 EGNIVKWLKKEGEAVSAGDALCEIETDKAVVTLDASDDGILAKIVVEEGS 66 >2O8R-A nrPDB Length = 705 Score = 30.8 bits (68), Expect = 1.9, Method: Compositional matrix adjust. Identities = 23/86 (26%), Positives = 38/86 (44%) Query: 485 IDGRRVEVSLPADLALSNGGGCDPVGVIRRKPKPRKRGAHTGAAASGDAVTAPMQGTVVK 544 +D ++VS ADL L D G IR+K K RK GA T G ++ Sbjct: 227 MDSYSIKVSRDADLLLDAQRPEDLPGEIRKKVKTRKLGAPTRFMYDGRMPDEVLRYICSS 286 Query: 545 FAVEEGQEVVAGDLVVVLEAMKMENP 570 ++ + + +G+ V + + + NP Sbjct: 287 CDIDPEEAIRSGNYVNLQDLAMLPNP 312 >3WVR-A nrPDB Length = 447 Score = 30.0 bits (66), Expect = 2.9, Method: Compositional matrix adjust. Identities = 32/106 (30%), Positives = 47/106 (44%), Gaps = 12/106 (11%) Query: 203 GRGECYVERYLDKPRHVEAQV-IADQHGNVVVAGTRDCSLQRRYQKLVEE--APAPFLTD 259 GR VERY R A+ I+D G V + G + RY+ L + PAP L Sbjct: 236 GRHRVVVERYHPGSRAYFAEFWISD--GGVRLGGHGEM----RYRPLPDSQVMPAPDLDQ 289 Query: 260 FQRKEIHDSAKRICKEAH---YHGAGTVEYLVGQDGLISFLEVNTR 302 Q ++ + +R+C H Y G + + +V G + F E N R Sbjct: 290 AQLDDLVEGGRRLCVALHALGYRGVLSADAVVTPAGEVLFTEHNGR 335 >5VEV-A nrPDB Length = 431 Score = 29.3 bits (64), Expect = 5.2, Method: Compositional matrix adjust. Identities = 24/79 (30%), Positives = 34/79 (43%), Gaps = 2/79 (2%) Query: 108 AGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPGTPDPVKGADEVVAFAEEYGLPIAI 167 AGL GP+ + + K A+ + P + AD + + G PI I Sbjct: 93 AGLKIFGPTQYAAQLESSKDFAKAFMVKYNIP--TAQYQTFENADAAHDYVNQKGAPIVI 150 Query: 168 KAAHGGGGKGMKVARTIDE 186 KA GKG+ VA T+DE Sbjct: 151 KADGLVAGKGVIVAMTLDE 169 >2CZG-A nrPDB Length = 433 Score = 29.3 bits (64), Expect = 5.5, Method: Compositional matrix adjust. Identities = 21/64 (32%), Positives = 30/64 (46%), Gaps = 4/64 (6%) Query: 152 DEVVAFAEEYGLPIAIKAAHGGGGKGMKVARTIDEIPELYESAVREATAAFGRGE-CYVE 210 DE+ E+ G P KA GKG + ++IP+ +E A T A G E VE Sbjct: 146 DELYEACEKIGYPCHTKAIMSSSGKGSYFVKGPEDIPKAWEEA---KTKARGSAEKIIVE 202 Query: 211 RYLD 214 ++D Sbjct: 203 EHID 206 >2YW2-A nrPDB Length = 424 Score = 28.9 bits (63), Expect = 5.9, Method: Compositional matrix adjust. Identities = 81/403 (20%), Positives = 148/403 (36%), Gaps = 67/403 (16%) Query: 72 DFAKILDAAAKSGANAIHPGYGFLAENADFAQAVIDA----GLIWIGPSPQSIRDLGDKV 127 D K+ + A G + + + A + ++D GL GP+ ++ + G K Sbjct: 50 DVEKLAEFAKNEGVD-----FTIVGPEAPLVEGIVDEFEKRGLKIFGPNKEAAKLEGSKA 104 Query: 128 TARHIAARAQAPLVPGTPDPVKGADEVVAFAEEYGLPIAIKAAHGGGGKGMKVARTIDEI 187 A+ + P + ++ + E+ G PI +KA GKG V T+++ Sbjct: 105 FAKTFMKKYGIP--TARYEVFTDFEKAKEYVEKVGAPIVVKADGLAAGKGAVVCETVEKA 162 Query: 188 PELYESAVREATAAFGRGECYVERYLDKPRHVEAQVIADQHGNVVVAGTRDCSL--QRRY 245 E + + + +E +L+ EA I V++ G R L + + Sbjct: 163 IETLDRFLNKKIFGKSSERVVIEEFLEGE---EASYI------VMINGDRYVPLPTSQDH 213 Query: 246 QKLVEE------------APAPFLTDFQRKEIHDS-AKRICKEA-----HYHGAGTVEYL 287 ++L++E +P P + + K I + +R+ K +Y G + Sbjct: 214 KRLLDEDKGPNTGGMGAYSPTPVINEEVEKRIREEIVERVIKGLKEEGIYYRGFLYAGLM 273 Query: 288 VGQDGLISFLEVNTRL--QVEHPVTEETAGIDLVLQQFRIANGEKLDITEDP-------- 337 + ++G LE N RL P+ D + G+ + I ED Sbjct: 274 ITKEGP-KVLEFNVRLGDPEAQPILMRVKN-DFLETLLNFYEGKDVHIKEDERYALDVVL 331 Query: 338 TPRGHAIEFRINGEDAGRNFLPAPGPVTKFHPPSGPGVRVDSGVETGSVIGGQFDSMLAK 397 RG+ + G ++L + V FH G + + S GG+ ++ A Sbjct: 332 ASRGYPEKPETGKIIHGLDYLKSMEDVVVFH----AGTKKEGNFTVTS--GGRVLNVCA- 384 Query: 398 LIVHGADRAEALARARRALNEFGVEGLATVIPFHRAVVSDPAF 440 +G EA RA A+ EG+ +R + D AF Sbjct: 385 ---YGKTLKEAKERAYEAIRYVCFEGMH-----YRKDIGDKAF 419 >2KNJ-A nrPDB Length = 90 Score = 28.9 bits (63), Expect = 6.4, Method: Composition-based stats. Identities = 13/30 (43%), Positives = 20/30 (66%) Query: 249 VEEAPAPFLTDFQRKEIHDSAKRICKEAHY 278 +E+A + + T+ Q KEIHD+A EAH+ Sbjct: 57 LEQAMSVYFTNEQIKEIHDAATACDPEAHH 86 >4NAR-A nrPDB Length = 435 Score = 28.5 bits (62), Expect = 8.1, Method: Compositional matrix adjust. Identities = 18/57 (31%), Positives = 25/57 (43%) Query: 187 IPELYESAVREATAAFGRGECYVERYLDKPRHVEAQVIADQHGNVVVAGTRDCSLQR 243 I E YE +R A +Y+D+P QVI +++ V AG LQR Sbjct: 238 IDEGYEGFLRAYEKACELSSQLHVKYIDRPLRRAVQVIGEEYDEVWTAGKGSYKLQR 294 >4PYS-A nrPDB Length = 506 Score = 28.5 bits (62), Expect = 8.3, Method: Compositional matrix adjust. Identities = 18/57 (31%), Positives = 27/57 (47%), Gaps = 1/57 (1%) Query: 219 VEAQVIADQHGNVVVAGTRDCSLQRRYQKLVEEAPAPFLTDFQRKEIHDSAKRICKE 275 + Q+I G + A R LQ + + EE+P F+ F K + +SA CKE Sbjct: 6 LSGQIIMPTPGKIERADGR-LRLQGKIRMYAEESPGSFIRLFYEKLVPESAVEWCKE 61 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 5MLK-A nrPDB 828 0.0 3U9T-A nrPDB 709 0.0 3N6R-A nrPDB 657 0.0 2VPQ-A nrPDB 629 e-180 3JZF-A nrPDB 619 e-177 4RZQ-A nrPDB 617 e-177 2C00-A nrPDB 612 e-175 1ULZ-A nrPDB 602 e-172 2DZD-A nrPDB 595 e-170 3OUU-A nrPDB 591 e-169 2YL2-A nrPDB 569 e-162 3JRW-A nrPDB 561 e-160 1W93-A nrPDB 537 e-153 5H80-A nrPDB 497 e-141 5KS8-A nrPDB 351 4e-97 6DGI-A nrPDB 206 3e-53 5KS8-C nrPDB 169 3e-42 2CQY-A nrPDB 119 3e-27 1A6X-A nrPDB 90 3e-18 4HR7-B nrPDB 88 1e-17 5CSA-A nrPDB 87 2e-17 Sequences not found previously or not previously below threshold: 4C5A-A nrPDB 101 1e-21 5D8D-A nrPDB 98 9e-21 2I87-A nrPDB 95 8e-20 3I12-A nrPDB 92 5e-19 2FB9-A nrPDB 92 7e-19 1E4E-B nrPDB 90 3e-18 3K3P-A nrPDB 87 3e-17 5BPF-A nrPDB 86 5e-17 3AW8-A nrPDB 86 5e-17 4EG0-A nrPDB 85 6e-17 4EGJ-A nrPDB 83 4e-16 4FU0-A nrPDB 82 6e-16 3LWB-A nrPDB 80 4e-15 3E5N-A nrPDB 76 3e-14 3ORR-A nrPDB 76 4e-14 3TQT-A nrPDB 76 4e-14 5NRH-A nrPDB 74 1e-13 3QFF-A nrPDB 74 1e-13 2YW2-A nrPDB 74 2e-13 3AX6-A nrPDB 74 2e-13 1EHI-A nrPDB 73 3e-13 3R5X-A nrPDB 70 3e-12 4E4T-A nrPDB 66 4e-11 2CZG-A nrPDB 65 7e-11 3VPD-A nrPDB 65 7e-11 4IZO-A nrPDB 65 9e-11 4DIM-A nrPDB 64 2e-10 1UC8-A nrPDB 61 1e-09 3K5H-A nrPDB 61 1e-09 1EZ1-A nrPDB 60 3e-09 2PVP-A nrPDB 59 5e-09 2YS6-A nrPDB 58 2e-08 2XD4-A nrPDB 57 2e-08 2IP4-A nrPDB 55 7e-08 4MAM-A nrPDB 55 8e-08 2PN1-A nrPDB 55 9e-08 2QK4-A nrPDB 54 2e-07 5VEV-A nrPDB 54 2e-07 1GSO-A nrPDB 54 2e-07 3MJF-A nrPDB 54 2e-07 3WO0-A nrPDB 54 2e-07 1VKZ-A nrPDB 50 2e-06 2Z04-A nrPDB 48 1e-05 3LP8-A nrPDB 48 2e-05 1IYU-A nrPDB 47 2e-05 4WD3-A nrPDB 44 1e-04 1ZY8-K nrPDB 43 5e-04 2R84-A nrPDB 43 5e-04 3DUF-I nrPDB 42 5e-04 2K7V-A nrPDB 41 0.002 1QJO-A nrPDB 40 0.004 3UFX-B nrPDB 38 0.014 3WVR-A nrPDB 38 0.014 6CT0-0 nrPDB 35 0.066 1WR2-A nrPDB 34 0.15 4XZ3-B nrPDB 33 0.25 3ZQ4-A nrPDB 33 0.28 1SVC-P nrPDB 32 0.54 4NAR-A nrPDB 32 0.56 4DK0-A nrPDB 31 1.2 4HGN-A nrPDB 31 1.3 3MXU-A nrPDB 31 1.3 3HHS-B nrPDB 31 1.4 1ONL-A nrPDB 31 1.4 4JE5-A nrPDB 31 1.5 2CV2-A nrPDB 31 1.6 3K9D-A nrPDB 31 1.8 1ZP9-A nrPDB 31 1.9 3TZU-A nrPDB 30 2.1 2KA7-A nrPDB 30 2.5 3A8J-E nrPDB 30 2.7 4XFJ-A nrPDB 30 3.2 5N6U-A nrPDB 30 3.5 3LNN-A nrPDB 29 5.7 4WKG-A nrPDB 29 6.7 4OEL-A nrPDB 29 7.0 2PZ0-A nrPDB 28 8.6 3ZUK-A nrPDB 28 8.9 3FWW-A nrPDB 28 9.4 >5MLK-A nrPDB Length = 614 Score = 828 bits (2139), Expect = 0.0, Method: Composition-based stats. Identities = 600/600 (100%), Positives = 600/600 (100%) Query: 1 MASHAGSRIARISKVLVANRGEIAVRVIRAARDAGLPSVAVYAEPDAESPHVRLADEAFA 60 MASHAGSRIARISKVLVANRGEIAVRVIRAARDAGLPSVAVYAEPDAESPHVRLADEAFA Sbjct: 15 MASHAGSRIARISKVLVANRGEIAVRVIRAARDAGLPSVAVYAEPDAESPHVRLADEAFA 74 Query: 61 LGGQTSAESYLDFAKILDAAAKSGANAIHPGYGFLAENADFAQAVIDAGLIWIGPSPQSI 120 LGGQTSAESYLDFAKILDAAAKSGANAIHPGYGFLAENADFAQAVIDAGLIWIGPSPQSI Sbjct: 75 LGGQTSAESYLDFAKILDAAAKSGANAIHPGYGFLAENADFAQAVIDAGLIWIGPSPQSI 134 Query: 121 RDLGDKVTARHIAARAQAPLVPGTPDPVKGADEVVAFAEEYGLPIAIKAAHGGGGKGMKV 180 RDLGDKVTARHIAARAQAPLVPGTPDPVKGADEVVAFAEEYGLPIAIKAAHGGGGKGMKV Sbjct: 135 RDLGDKVTARHIAARAQAPLVPGTPDPVKGADEVVAFAEEYGLPIAIKAAHGGGGKGMKV 194 Query: 181 ARTIDEIPELYESAVREATAAFGRGECYVERYLDKPRHVEAQVIADQHGNVVVAGTRDCS 240 ARTIDEIPELYESAVREATAAFGRGECYVERYLDKPRHVEAQVIADQHGNVVVAGTRDCS Sbjct: 195 ARTIDEIPELYESAVREATAAFGRGECYVERYLDKPRHVEAQVIADQHGNVVVAGTRDCS 254 Query: 241 LQRRYQKLVEEAPAPFLTDFQRKEIHDSAKRICKEAHYHGAGTVEYLVGQDGLISFLEVN 300 LQRRYQKLVEEAPAPFLTDFQRKEIHDSAKRICKEAHYHGAGTVEYLVGQDGLISFLEVN Sbjct: 255 LQRRYQKLVEEAPAPFLTDFQRKEIHDSAKRICKEAHYHGAGTVEYLVGQDGLISFLEVN 314 Query: 301 TRLQVEHPVTEETAGIDLVLQQFRIANGEKLDITEDPTPRGHAIEFRINGEDAGRNFLPA 360 TRLQVEHPVTEETAGIDLVLQQFRIANGEKLDITEDPTPRGHAIEFRINGEDAGRNFLPA Sbjct: 315 TRLQVEHPVTEETAGIDLVLQQFRIANGEKLDITEDPTPRGHAIEFRINGEDAGRNFLPA 374 Query: 361 PGPVTKFHPPSGPGVRVDSGVETGSVIGGQFDSMLAKLIVHGADRAEALARARRALNEFG 420 PGPVTKFHPPSGPGVRVDSGVETGSVIGGQFDSMLAKLIVHGADRAEALARARRALNEFG Sbjct: 375 PGPVTKFHPPSGPGVRVDSGVETGSVIGGQFDSMLAKLIVHGADRAEALARARRALNEFG 434 Query: 421 VEGLATVIPFHRAVVSDPAFIGDANGFSVHTRWIETEWNNTIEPFTDGEPLDEDARPRQK 480 VEGLATVIPFHRAVVSDPAFIGDANGFSVHTRWIETEWNNTIEPFTDGEPLDEDARPRQK Sbjct: 435 VEGLATVIPFHRAVVSDPAFIGDANGFSVHTRWIETEWNNTIEPFTDGEPLDEDARPRQK 494 Query: 481 VVVEIDGRRVEVSLPADLALSNGGGCDPVGVIRRKPKPRKRGAHTGAAASGDAVTAPMQG 540 VVVEIDGRRVEVSLPADLALSNGGGCDPVGVIRRKPKPRKRGAHTGAAASGDAVTAPMQG Sbjct: 495 VVVEIDGRRVEVSLPADLALSNGGGCDPVGVIRRKPKPRKRGAHTGAAASGDAVTAPMQG 554 Query: 541 TVVKFAVEEGQEVVAGDLVVVLEAMKMENPVTAHKDGTITGLAVEAGAAITQGTVLAEIK 600 TVVKFAVEEGQEVVAGDLVVVLEAMKMENPVTAHKDGTITGLAVEAGAAITQGTVLAEIK Sbjct: 555 TVVKFAVEEGQEVVAGDLVVVLEAMKMENPVTAHKDGTITGLAVEAGAAITQGTVLAEIK 614 >3U9T-A nrPDB Length = 655 Score = 709 bits (1830), Expect = 0.0, Method: Composition-based stats. Identities = 263/644 (40%), Positives = 347/644 (53%), Gaps = 55/644 (8%) Query: 12 ISKVLVANRGEIAVRVIRAARDAGLPSVAVYAEPDAESPHVRLADEAFALGGQTSAESYL 71 I ++LVANRGEIA RV+R+AR G+ SVAV+++ D + HV AD A LGG A+SYL Sbjct: 8 IQRLLVANRGEIACRVMRSARALGIGSVAVHSDIDRHARHVAEADIAVDLGGAKPADSYL 67 Query: 72 DFAKILDAAAKSGANAIHPGYGFLAENADFAQAVIDAGLIWIGPSPQSIRDLGDKVTARH 131 +I+ AA SGA AIHPGYGFL+ENADFA+A +AGL+++GP +I +G K A+ Sbjct: 68 RGDRIIAAALASGAQAIHPGYGFLSENADFARACEEAGLLFLGPPAAAIDAMGSKSAAKA 127 Query: 132 IAARAQAPLVPGTPDPVKGADEVVAFAEEYGLPIAIKAAHGGGGKGMKVARTIDEIPELY 191 + A PLVPG + + A G P+ +KAA GGGGKGMKV E+ E Sbjct: 128 LMEEAGVPLVPGYHGEAQDLETFRREAGRIGYPVLLKAAAGGGGKGMKVVEREAELAEAL 187 Query: 192 ESAVREATAAFGRGECYVERYLDKPRHVEAQVIADQHGNVVVAGTRDCSLQRRYQKLVEE 251 SA REA AAFG VE+YL KPRHVE QV AD+HG+ + RDCS+QRR+QK+VEE Sbjct: 188 SSAQREAKAAFGDARMLVEKYLLKPRHVEIQVFADRHGHCLYLNERDCSIQRRHQKVVEE 247 Query: 252 APAPFLTDFQRKEIHDSAKRICKEAHYHGAGTVEYLVGQDGLISFLEVNTRLQVEHPVTE 311 APAP L R+ + ++A R + Y GAGTVE+L+ + G F+E+NTRLQVEHPVTE Sbjct: 248 APAPGLGAELRRAMGEAAVRAAQAIGYVGAGTVEFLLDERGQFFFMEMNTRLQVEHPVTE 307 Query: 312 ETAGIDLVLQQFRIANGEKLDITEDPTP-RGHAIEFRINGEDAGRNFLPAPGPVTKFH-P 369 G+DLV Q R+A GE L +T++ P GHAIE R+ ED +FLPA G + + Sbjct: 308 AITGLDLVAWQIRVARGEALPLTQEQVPLNGHAIEVRLYAEDPEGDFLPASGRLMLYREA 367 Query: 370 PSGPGVRVDSGVETGSVIGGQFDSMLAKLIVHGADRAEALARARRALNEFGVEGLATVIP 429 +GPG RVDSGV G + +D MLAKLI G R EA R L E V GL T + Sbjct: 368 AAGPGRRVDSGVREGDEVSPFYDPMLAKLIAWGETREEARQRLLAMLAETSVGGLRTNLA 427 Query: 430 FHRAVVSDPAFIG---DANGFSVHTRWI--------ETEWNNTIEPFTDGEP---LDED- 474 F R ++ PAF D + H + E W E + EP D+D Sbjct: 428 FLRRILGHPAFAAAELDTGFIARHQDDLLPAPQALPEHFWQAAAEAWLQSEPGHRRDDDP 487 Query: 475 --------------ARPRQKVVVEIDGR---RVEVSLPADLALSNGGGCDPVGVIRRKPK 517 AR ++ D R R+ + P+ L V + R+ Sbjct: 488 HSPWSRNDGWRSALARESDLMLRCRDERRCVRLRHASPSQYRLDGDDLVSRVDGVTRRSA 547 Query: 518 PRKRGAHTGAAASGD---------------------AVTAPMQGTVVKFAVEEGQEVVAG 556 +RG G+ ++APM G++V+ VE GQ V AG Sbjct: 548 ALRRGRQLFLEWEGELLAIEAVDPIAEAEAAHAHQGGLSAPMNGSIVRVLVEPGQTVEAG 607 Query: 557 DLVVVLEAMKMENPVTAHKDGTITGLAVEAGAAITQGTVLAEIK 600 +VVLEAMKME+ + A G + L G + +GT L E+ Sbjct: 608 ATLVVLEAMKMEHSIRAPHAGVVKALYCSEGELVEEGTPLVELD 651 >3N6R-A nrPDB Length = 681 Score = 657 bits (1694), Expect = 0.0, Method: Composition-based stats. Identities = 243/686 (35%), Positives = 347/686 (50%), Gaps = 103/686 (15%) Query: 12 ISKVLVANRGEIAVRVIRAARDAGLPSVAVYAEPDAESPHVRLADEAFALGGQTSAESYL 71 +K+L+ANRGEIA RVI+ AR G+ +VA+Y++ D ++ HV++ADEA +G + +SY+ Sbjct: 2 FNKILIANRGEIACRVIKTARKMGISTVAIYSDADKQALHVQMADEAVHIGPPPANQSYI 61 Query: 72 DFAKILDAAAKSGANAIHPGYGFLAENADFAQAVIDAGLIWIGPSPQSIRDLGDKVTARH 131 K++ A +GA A+HPGYGFL+EN+ FA+A+ G+I++GP +I +GDK+T++ Sbjct: 62 VIDKVMAAIRATGAQAVHPGYGFLSENSKFAEALEAEGVIFVGPPKGAIEAMGDKITSKK 121 Query: 132 IAARAQAPLVPGTPDPVKGADEVVAFAEEYGLPIAIKAAHGGGGKGMKVARTIDEIPELY 191 IA A VPG ++ ADE V + + G P+ IKA+ GGGGKGM++A E E + Sbjct: 122 IAQEANVSTVPGYMGLIEDADEAVKISNQIGYPVMIKASAGGGGKGMRIAWNDQEAREGF 181 Query: 192 ESAVREATAAFGRGECYVERYLDKPRHVEAQVIADQHGNVVVAGTRDCSLQRRYQKLVEE 251 +S+ EA +FG ++E+++ +PRH+E QV+ D HGN + G R+CS+QRR QK+VEE Sbjct: 182 QSSKNEAANSFGDDRIFIEKFVTQPRHIEIQVLCDSHGNGIYLGERECSIQRRNQKVVEE 241 Query: 252 APAPFLTDFQRKEIHDSAKRICKEAHYHGAGTVEYLVGQDGLISFLEVNTRLQVEHPVTE 311 AP+PFL + R+ + + A + K Y AGTVE++V FLE+NTRLQVEHPVTE Sbjct: 242 APSPFLDEATRRAMGEQAVALAKAVGYASAGTVEFIVDGQKNFYFLEMNTRLQVEHPVTE 301 Query: 312 ETAGIDLVLQQFRIANGEKLDITE-DPTPRGHAIEFRINGEDAGRNFLPAPGPVTKFHPP 370 G+DLV Q R+A GE L IT+ D G AIE R+ ED R FLP+ G +T++ PP Sbjct: 302 LITGVDLVEQMIRVAAGEPLSITQGDVKLTGWAIENRLYAEDPYRGFLPSIGRLTRYRPP 361 Query: 371 ----SGP----------------GVRVDSGVETGSVIGGQFDSMLAKLIVHGADRAEALA 410 +GP VR D+GV G I +D M+AKL RA A+ Sbjct: 362 AETAAGPLLVNGKWQGDAPSGEAAVRNDTGVYEGGEISMYYDPMIAKLCTWAPTRAAAIE 421 Query: 411 RARRALNEFGVEGLATVIPFHRAVVSDPAFIGD--------------------------- 443 R AL+ F VEG+ +PF AV+ P FI Sbjct: 422 AMRIALDSFEVEGIGHNLPFLSAVMDHPKFISGDMTTAFIAEEYPEGFEGVNLPETDLRR 481 Query: 444 -------------------ANGFSVHTRWIETEWNNTIE----PFTDGEPLDEDARPRQK 480 + H R + TEW T++ P T D Sbjct: 482 VAAAAAAMHRVAEIRRTRVSGRMDNHERRVGTEWVVTLQGADFPVTIAADHDGSTVSFD- 540 Query: 481 VVVEIDGRRVEVSLP-------ADLALSNGGGCDPVGVIRRKPKPRKRGAHTGAAA---- 529 DG + V+ A+L + VG I + R RGA Sbjct: 541 -----DGSSMRVTSDWTPGDQLANLMVDGAPLVLKVGKISGGFRIRTRGADLKVHVRTPR 595 Query: 530 ---------------SGDAVTAPMQGTVVKFAVEEGQEVVAGDLVVVLEAMKMENPVTAH 574 + + PM G +VK VE GQEV G + +EAMKMEN + A Sbjct: 596 QAELARLMPEKLPPDTSKMLLCPMPGLIVKVDVEVGQEVQEGQALCTIEAMKMENILRAE 655 Query: 575 KDGTITGLAVEAGAAITQGTVLAEIK 600 K G + + AG ++ V+ E + Sbjct: 656 KKGVVAKINASAGNSLAVDDVIMEFE 681 >2VPQ-A nrPDB Length = 451 Score = 629 bits (1621), Expect = e-180, Method: Composition-based stats. Identities = 204/446 (45%), Positives = 289/446 (64%), Gaps = 6/446 (1%) Query: 12 ISKVLVANRGEIAVRVIRAARDAGLPSVAVYAEPDAESPHVRLADEAFALGGQTSAESYL 71 + KVL+ANRGEIAVR+IRA RD G+ +VA+Y+E D ++ H ++ADEA+ +G S +SYL Sbjct: 1 MKKVLIANRGEIAVRIIRACRDLGIQTVAIYSEGDKDALHTQIADEAYCVGPTLSKDSYL 60 Query: 72 DFAKILDAAAKSGANAIHPGYGFLAENADFAQAVIDAGLIWIGPSPQSIRDLGDKVTARH 131 + IL A +G + +HPGYGFLAENADFA+ L +IGPS QSI+ +G K A+ Sbjct: 61 NIPNILSIATSTGCDGVHPGYGFLAENADFAELCEACQLKFIGPSYQSIQKMGIKDVAKA 120 Query: 132 IAARAQAPLVPGTPDPVKGADEVVAFAEEYGLPIAIKAAHGGGGKGMKVARTIDEIPELY 191 +A P+VPG+ +K E A++ G P+ IKA GGGGKG++VAR E+ + Sbjct: 121 EMIKANVPVVPGSDGLMKDVSEAKKIAKKIGYPVIIKATAGGGGKGIRVARDEKELETGF 180 Query: 192 ESAVREATAAFGRGECYVERYLDKPRHVEAQVIADQHGNVVVAGTRDCSLQRRYQKLVEE 251 +EA AFG G Y+E++++ RH+E Q++ D +GNV+ G RDC++QRR QKLVEE Sbjct: 181 RMTEQEAQTAFGNGGLYMEKFIENFRHIEIQIVGDSYGNVIHLGERDCTIQRRMQKLVEE 240 Query: 252 APAPFLTDFQRKEIHDSAKRICKEAHYHGAGTVEYLVG-QDGLISFLEVNTRLQVEHPVT 310 AP+P L D R+E+ ++A R K +Y AGT+E++ D F+E+NTR+QVEHPVT Sbjct: 241 APSPILDDETRREMGNAAVRAAKAVNYENAGTIEFIYDLNDNKFYFMEMNTRIQVEHPVT 300 Query: 311 EETAGIDLVLQQFRIANGEKLDIT-EDPTPRGHAIEFRINGEDAGRNFLPAPGPVTKFHP 369 E GIDLV Q ++A G+ L ED GHAIEFRIN E+ +NF+P+PG + ++ Sbjct: 301 EMVTGIDLVKLQLQVAMGDVLPYKQEDIKLTGHAIEFRINAENPYKNFMPSPGKIEQYLA 360 Query: 370 PSGPGVRVDSGVETGSVIGGQFDSMLAKLIVHGADRAEALARARRALNEFGVEGLATVIP 429 P G GVR++S T I +DSM+AKLI+H R EA+ RAL+EF V G+ T IP Sbjct: 361 PGGYGVRIESACYTNYTIPPYYDSMVAKLIIHEPTRDEAIMAGIRALSEFVVLGIDTTIP 420 Query: 430 FHRAVVSDPAFIGDANGFSVHTRWIE 455 FH ++++ F + F+ T ++E Sbjct: 421 FHIKLLNNDIF--RSGKFN--TNFLE 442 >3JZF-A nrPDB Length = 486 Score = 619 bits (1596), Expect = e-177, Method: Composition-based stats. Identities = 198/441 (44%), Positives = 284/441 (64%), Gaps = 6/441 (1%) Query: 12 ISKVLVANRGEIAVRVIRAARDAGLPSVAVYAEPDAESPHVRLADEAFALGGQTSAESYL 71 + K+++ANRGEIA+R++RA ++ G+ +VAV++ D + HV LADE +G S +SYL Sbjct: 23 LDKIVIANRGEIALRILRACKELGIKTVAVHSSADRDLKHVLLADETVCIGPAPSVKSYL 82 Query: 72 DFAKILDAAAKSGANAIHPGYGFLAENADFAQAVIDAGLIWIGPSPQSIRDLGDKVTARH 131 + I+ AA +GA AIHPGYGFL+ENA+FA+ V +G I+IGP ++IR +GDKV+A Sbjct: 83 NIPAIISAAEITGAVAIHPGYGFLSENANFAEQVERSGFIFIGPKAETIRLMGDKVSAIA 142 Query: 132 IAARAQAPLVPGTPDPV-KGADEVVAFAEEYGLPIAIKAAHGGGGKGMKVARTIDEIPEL 190 +A P VPG+ P+ D+ A A+ G P+ IKA+ GGGG+GM+V R E+ + Sbjct: 143 AMKKAGVPCVPGSDGPLGDDMDKNRAIAKRIGYPVIIKASGGGGGRGMRVVRGDAELAQS 202 Query: 191 YESAVREATAAFGRGECYVERYLDKPRHVEAQVIADQHGNVVVAGTRDCSLQRRYQKLVE 250 EA AAF Y+E+YL+ PRHVE QV+AD GN + RDCS+QRR+QK+VE Sbjct: 203 ISMTRAEAKAAFSNDMVYMEKYLENPRHVEIQVLADGQGNAIYLAERDCSMQRRHQKVVE 262 Query: 251 EAPAPFLTDFQRKEIHDSAKRICKEAHYHGAGTVEYLVGQDGLISFLEVNTRLQVEHPVT 310 EAPAP +T R+ I + + C + Y GAGT E+L ++G F+E+NTR+QVEHPVT Sbjct: 263 EAPAPGITPELRRYIGERCAKACVDIGYRGAGTFEFLF-ENGEFYFIEMNTRIQVEHPVT 321 Query: 311 EETAGIDLVLQQFRIANGEKLDITEDPTP-RGHAIEFRINGEDAGRNFLPAPGPVTKFHP 369 E G+DL+ +Q RIA G+ L I ++ RGHA+E RIN ED FLP+PG +T+FH Sbjct: 322 EMITGVDLIKEQLRIAAGQPLSIKQEEVHVRGHAVECRINAEDP-NTFLPSPGKITRFHA 380 Query: 370 PSGPGVRVDSGVETGSVIGGQFDSMLAKLIVHGADRAEALARARRALNEFGVEGLATVIP 429 P G GVR +S + G + +DSM+ KLI +G +R A+AR + AL E ++G+ T + Sbjct: 381 PGGFGVRWESHIYAGYTVPPYYDSMIGKLICYGENRDVAIARMKNALQELIIDGIKTNVD 440 Query: 430 FHRAVVSDPAFIGDANGFSVH 450 +++D F G ++H Sbjct: 441 LQIRIMNDENFQH--GGTNIH 459 >4RZQ-A nrPDB Length = 468 Score = 617 bits (1591), Expect = e-177, Method: Composition-based stats. Identities = 208/441 (47%), Positives = 281/441 (63%), Gaps = 6/441 (1%) Query: 12 ISKVLVANRGEIAVRVIRAARDAGLPSVAVYAEPDAESPHVRLADEAFALGGQTSAESYL 71 + KV++ANRGEIA+R++RA ++ G+ +VAV++ D + HV LADE +G SA+SYL Sbjct: 22 LEKVVIANRGEIALRILRACKELGIKTVAVHSTADRDLKHVLLADETICIGPAPSAKSYL 81 Query: 72 DFAKILDAAAKSGANAIHPGYGFLAENADFAQAVIDAGLIWIGPSPQSIRDLGDKVTARH 131 + I+ AA +GA+AIHPGYGFL+ENADFA+ V +G +IGP+ IR +GDKV+A Sbjct: 82 NIPAIIAAAEVTGADAIHPGYGFLSENADFAEQVERSGFTFIGPTADVIRLMGDKVSAIK 141 Query: 132 IAARAQAPLVPGTPDPV-KGADEVVAFAEEYGLPIAIKAAHGGGGKGMKVARTIDEIPEL 190 +A P VPG+ PV + A+ G PI IKA+ GGGG+GM+V R+ D + E Sbjct: 142 AMKKAGVPCVPGSDGPVSNDIAKNKEIAKRIGYPIIIKASGGGGGRGMRVVRSEDALEES 201 Query: 191 YESAVREATAAFGRGECYVERYLDKPRHVEAQVIADQHGNVVVAGTRDCSLQRRYQKLVE 250 EA AAF Y+E+YL+ PRHVE QV+AD HGN V RDCS+QRR+QK+VE Sbjct: 202 IAMTKAEAKAAFNNDMVYMEKYLENPRHVEIQVLADTHGNAVYLAERDCSMQRRHQKVVE 261 Query: 251 EAPAPFLTDFQRKEIHDSAKRICKEAHYHGAGTVEYLVGQDGLISFLEVNTRLQVEHPVT 310 EAPAP +T+ R++I C E Y GAGT E+L ++G F+E+NTR+QVEHPVT Sbjct: 262 EAPAPGITEEVRRDIGSRCANACVEIGYRGAGTFEFLY-ENGEFYFIEMNTRIQVEHPVT 320 Query: 311 EETAGIDLVLQQFRIANGEKLDIT-EDPTPRGHAIEFRINGEDAGRNFLPAPGPVTKFHP 369 E G+DLV +Q RIA G + ED +GHA+E RIN ED + FLP+PG V H Sbjct: 321 EMITGVDLVKEQLRIAAGLPISFKQEDIKVKGHAMECRINAEDP-KTFLPSPGKVNHLHS 379 Query: 370 PSGPGVRVDSGVETGSVIGGQFDSMLAKLIVHGADRAEALARARRALNEFGVEGLATVIP 429 P G GVR DS V G + +DSM+AKLI +G R A+ R + AL+E ++G+ T IP Sbjct: 380 PGGLGVRWDSHVYGGYTVPPHYDSMIAKLITYGDTREVAIRRMQNALSETIIDGIKTNIP 439 Query: 430 FHRAVVSDPAFIGDANGFSVH 450 H ++ D F G ++H Sbjct: 440 LHELILEDENF--QKGGTNIH 458 >2C00-A nrPDB Length = 464 Score = 612 bits (1579), Expect = e-175, Method: Composition-based stats. Identities = 210/441 (47%), Positives = 292/441 (66%), Gaps = 6/441 (1%) Query: 12 ISKVLVANRGEIAVRVIRAARDAGLPSVAVYAEPDAESPHVRLADEAFALGGQTSAESYL 71 + KVL+ANRGEIA+R++RA ++ G+ +VAV++ D E H+ LADE+ +G + +SYL Sbjct: 2 LEKVLIANRGEIALRILRACKELGIKTVAVHSTADRELMHLSLADESVCIGPAPATQSYL 61 Query: 72 DFAKILDAAAKSGANAIHPGYGFLAENADFAQAVIDAGLIWIGPSPQSIRDLGDKVTARH 131 I+ AA +GA AIHPGYGFLAENADFA+ + +G ++GP+ + IR +GDKV+A+ Sbjct: 62 QIPAIIAAAEVTGATAIHPGYGFLAENADFAEQIERSGFTFVGPTAEVIRLMGDKVSAKD 121 Query: 132 IAARAQAPLVPGTPDPVKGADE-VVAFAEEYGLPIAIKAAHGGGGKGMKVARTIDEIPEL 190 RA P VPG+ P+ +E +A A E G P+ IKAA GGGG+GM+V E+ + Sbjct: 122 AMKRAGVPTVPGSDGPLPEDEETALAIAREVGYPVIIKAAGGGGGRGMRVVYDESELIKS 181 Query: 191 YESAVREATAAFGRGECYVERYLDKPRHVEAQVIADQHGNVVVAGTRDCSLQRRYQKLVE 250 + EA AAFG Y+E++L PRHVE QV++D GN + G RDCSLQRR+QK++E Sbjct: 182 AKLTRTEAGAAFGNPMVYLEKFLTNPRHVEVQVLSDGQGNAIHLGDRDCSLQRRHQKVIE 241 Query: 251 EAPAPFLTDFQRKEIHDSAKRICKEAHYHGAGTVEYLVGQDGLISFLEVNTRLQVEHPVT 310 EAPAP + + R+E+ + C E Y GAGT E+L ++G F+E+NTR+QVEHPV+ Sbjct: 242 EAPAPGIDEKARQEVFARCVQACIEIGYRGAGTFEFLY-ENGRFYFIEMNTRVQVEHPVS 300 Query: 311 EETAGIDLVLQQFRIANGEKLDI-TEDPTPRGHAIEFRINGEDAGRNFLPAPGPVTKFHP 369 E G+D+V + RIA+GEKL I ED RGHA+E RIN ED + F+P+PG V FH Sbjct: 301 EMVTGVDIVKEMLRIASGEKLSIRQEDVVIRGHALECRINAEDP-KTFMPSPGKVKHFHA 359 Query: 370 PSGPGVRVDSGVETGSVIGGQFDSMLAKLIVHGADRAEALARARRALNEFGVEGLATVIP 429 P G GVRVDS + +G + +DS++ K+I +GADR EALAR R AL+E V+G+ T Sbjct: 360 PGGNGVRVDSHLYSGYSVPPNYDSLVGKVITYGADRDEALARMRNALDELIVDGIKTNTE 419 Query: 430 FHRAVVSDPAFIGDANGFSVH 450 H+ +V D AF G ++H Sbjct: 420 LHKDLVRDAAFC--KGGVNIH 438 >1ULZ-A nrPDB Length = 451 Score = 602 bits (1552), Expect = e-172, Method: Composition-based stats. Identities = 195/445 (43%), Positives = 293/445 (65%), Gaps = 6/445 (1%) Query: 12 ISKVLVANRGEIAVRVIRAARDAGLPSVAVYAEPDAESPHVRLADEAFALGGQTSAESYL 71 ++KVLVANRGEIAVR+IRA ++ G+P+VA+Y E ++ + HV+LADEA+ +G ++YL Sbjct: 2 VNKVLVANRGEIAVRIIRACKELGIPTVAIYNEVESTARHVKLADEAYMIGTDP-LDTYL 60 Query: 72 DFAKILDAAAKSGANAIHPGYGFLAENADFAQAVIDAGLIWIGPSPQSIRDLGDKVTARH 131 + +I++ A + GA+AIHPGYGFLAENA+FA+ +AG+ +IGP + I +GDK ++ Sbjct: 61 NKQRIINLALEVGADAIHPGYGFLAENAEFAKMCEEAGITFIGPHWKVIELMGDKARSKE 120 Query: 132 IAARAQAPLVPGTPDPVKGADEVVAFAEEYGLPIAIKAAHGGGGKGMKVARTIDEIPELY 191 + +A P+VPG+ +K +E A A E G P+ +KA GGGG+G+++ R +E+ + Y Sbjct: 121 VMKKAGVPVVPGSDGVLKSLEEAKALAREIGYPVLLKATAGGGGRGIRICRNEEELVKNY 180 Query: 192 ESAVREATAAFGRGECYVERYLDKPRHVEAQVIADQHGNVVVAGTRDCSLQRRYQKLVEE 251 E A REA AFGRG+ +E++++ P+H+E QV+ D+HGNV+ G RDCS+QRR QKLVE Sbjct: 181 EQASREAEKAFGRGDLLLEKFIENPKHIEYQVLGDKHGNVIHLGERDCSIQRRNQKLVEI 240 Query: 252 APAPFLTDFQRKEIHDSAKRICKEAHYHGAGTVEYLVGQDGLISFLEVNTRLQVEHPVTE 311 AP+ LT +R+ + + KE Y+ AGT+E++ Q+G + F+E+NTR+QVEHPV+E Sbjct: 241 APSLILTPEKREYYGNIVTKAAKEIGYYNAGTMEFIADQEGNLYFIEMNTRIQVEHPVSE 300 Query: 312 ETAGIDLVLQQFRIANGEKLDIT-EDPTPRGHAIEFRINGEDAGRNFLPAPGPVTKFHPP 370 GID+V Q +IA GE L I ED G+AIE RIN ED +NF P+ + +++ P Sbjct: 301 MVTGIDIVKWQIKIAAGEPLTIKQEDVKFNGYAIECRINAEDPKKNFAPSTRVIERYYVP 360 Query: 371 SGPGVRVDSGVETGSVIGGQFDSMLAKLIVHGADRAEALARARRALNEFGVEGLATVIPF 430 G G+RV+ G + +DSM+AKLI EA+ R R AL + + G+ T IP Sbjct: 361 GGFGIRVEHAAARGFEVTPYYDSMIAKLITWAPTWDEAVERMRAALETYEITGVKTTIPL 420 Query: 431 HRAVVSDPAFIGDANGFSVHTRWIE 455 ++ + F A F+ T+++E Sbjct: 421 LINIMKEKDF--KAGKFT--TKYLE 441 >2DZD-A nrPDB Length = 461 Score = 595 bits (1534), Expect = e-170, Method: Composition-based stats. Identities = 201/455 (44%), Positives = 277/455 (60%), Gaps = 14/455 (3%) Query: 11 RISKVLVANRGEIAVRVIRAARDAGLPSVAVYAEPDAESPHVRLADEAFALG-GQTSAES 69 RI KVLVANRGEIA+RV RA + G+ +VA+Y++ D S H ADEA+ +G G+ E+ Sbjct: 5 RIRKVLVANRGEIAIRVFRACTELGIRTVAIYSKEDVGSYHRYKADEAYLVGEGKKPIEA 64 Query: 70 YLDFAKILDAAAKSGANAIHPGYGFLAENADFAQAVIDAGLIWIGPSPQSIRDLGDKVTA 129 YLD I++ A +AIHPGYGFL+EN FA+ + G+I+IGP+ + GDKV A Sbjct: 65 YLDIEGIIEIAKAHDVDAIHPGYGFLSENIQFAKRCREEGIIFIGPNENHLDMFGDKVKA 124 Query: 130 RHIAARAQAPLVPGTPDPVKGADEVVAFAEEYGLPIAIKAAHGGGGKGMKVARTIDEIPE 189 RH A A P++PG+ PV G ++VVAFAE +G PI IKAA GGGG+GM++ R+ E+ E Sbjct: 125 RHAAVNAGIPVIPGSDGPVDGLEDVVAFAEAHGYPIIIKAALGGGGRGMRIVRSKSEVKE 184 Query: 190 LYESAVREATAAFGRGECYVERYLDKPRHVEAQVIADQHGNVVVAGTRDCSLQRRYQKLV 249 +E A EA AAFG E YVE+ ++ P+H+E Q++ D GN+V RDCS+QRR+QK+V Sbjct: 185 AFERAKSEAKAAFGSDEVYVEKLIENPKHIEVQILGDYEGNIVHLYERDCSVQRRHQKVV 244 Query: 250 EEAPAPFLTDFQRKEIHDSAKRICKEAHYHGAGTVEYLVGQDGLISFLEVNTRLQVEHPV 309 E AP+ L+D R+ I ++A ++ + Y AGTVE+LV D F+EVN R+QVEH + Sbjct: 245 EVAPSVSLSDELRQRICEAAVQLMRSVGYVNAGTVEFLVSGD-EFYFIEVNPRIQVEHTI 303 Query: 310 TEETAGIDLVLQQFRIANGEKLDIT-------EDPTPRGHAIEFRINGEDAGRNFLPAPG 362 TE GID+V Q IA+G L ED G+AI+ R+ ED NF+P G Sbjct: 304 TEMITGIDIVQSQILIADGCSLHSHEVGIPKQEDIRINGYAIQSRVTTEDPLNNFMPDTG 363 Query: 363 PVTKFHPPSGPGVRVDSGV-ETGSVIGGQFDSMLAKLIVHGADRAEALARARRALNEFGV 421 + + G GVR+D+G G+VI +DS+L KL +A + R L EF + Sbjct: 364 KIMAYRSGGGFGVRLDAGNGFQGAVITPYYDSLLVKLSTWALTFEQAARKMLRNLREFRI 423 Query: 422 EGLATVIPFHRAVVSDPAFIGDANGFSVHTRWIET 456 G+ T IPF VV P F+ T +I+T Sbjct: 424 RGIKTNIPFLENVVQHPKFLSG----EYDTSFIDT 454 >3OUU-A nrPDB Length = 446 Score = 591 bits (1524), Expect = e-169, Method: Composition-based stats. Identities = 183/447 (40%), Positives = 278/447 (62%), Gaps = 4/447 (0%) Query: 7 SRIARISKVLVANRGEIAVRVIRAARDAGLPSVAVYAEPDAESPHVRLADEAFALGGQTS 66 S I +L+ANRGEIA+R +R ++ G ++ VY+E D ++ +++ AD + +G S Sbjct: 1 SNAMEIKSILIANRGEIALRALRTIKEMGKKAICVYSEADKDALYLKYADASICIGKARS 60 Query: 67 AESYLDFAKILDAAAKSGANAIHPGYGFLAENADFAQAVIDAGLIWIGPSPQSIRDLGDK 126 +ESYL+ I+ AA + A+AI PGYGFL+EN +F + + +IGPS +++ + DK Sbjct: 61 SESYLNIPAIIAAAEIAEADAIFPGYGFLSENQNFVEICAKHNIKFIGPSVEAMNLMSDK 120 Query: 127 VTARHIAARAQAPLVPGTPDPVKGADEVVAFAEEYGLPIAIKAAHGGGGKGMKVARTIDE 186 A+ + RA P++PG+ + GA+ A+E G P+ +KAA GGGG+GM+V + Sbjct: 121 SKAKQVMQRAGVPVIPGSDGALAGAEAAKKLAKEIGYPVILKAAAGGGGRGMRVVENEKD 180 Query: 187 IPELYESAVREATAAFGRGECYVERYLDKPRHVEAQVIADQHGNVVVAGTRDCSLQRRYQ 246 + + Y SA EA AFG G Y+E+Y+ PRH+E QVI D GNV+ G RDCS+QRR+Q Sbjct: 181 LEKAYWSAESEAMTAFGDGTMYMEKYIQNPRHIEVQVIGDSFGNVIHVGERDCSMQRRHQ 240 Query: 247 KLVEEAPAPFLTDFQRKEIHDSAKRICKEAHYHGAGTVEYLVGQDGLISFLEVNTRLQVE 306 KL+EE+PA L + R +H++A + K Y GAGT E+LV ++ F+E+NTRLQVE Sbjct: 241 KLIEESPAILLDEKTRTRLHETAIKAAKAIGYEGAGTFEFLVDKNLDFYFIEMNTRLQVE 300 Query: 307 HPVTEETAGIDLVLQQFRIANGEKLDITEDPTPRGHAIEFRINGEDAGRNFLPAPGPVTK 366 H V+E +GID++ Q ++A G L E GH+IE RI ED+ + FLP+PG +TK Sbjct: 301 HCVSEMVSGIDIIEQMIKVAEGYALPSQESIKLNGHSIECRITAEDS-KTFLPSPGKITK 359 Query: 367 FHPPSGPGVRVDSGVETGSVIGGQFDSMLAKLIVHGADRAEALARARRALNEFGVEGLAT 426 + PP+G VR++S + +DSM+ KL+V DR +A+A+ + AL+E + G+ T Sbjct: 360 YIPPAGRNVRMESHCYQDYSVPAYYDSMIGKLVVWAEDRNKAIAKMKVALDELLISGIKT 419 Query: 427 VIPFHRAVVSDPAFIG---DANGFSVH 450 FH +++ +P FI D N + H Sbjct: 420 TKDFHLSMMENPDFINNNYDTNYLARH 446 >2YL2-A nrPDB Length = 540 Score = 569 bits (1467), Expect = e-162, Method: Composition-based stats. Identities = 152/516 (29%), Positives = 234/516 (45%), Gaps = 71/516 (13%) Query: 1 MASHAGSRIARISKVLVANRGEIAVRVIRAARDAGLP--------SVAVYAEPD---AES 49 + G+++ I KVL+AN G AV+ +R+ R V P+ A + Sbjct: 32 VTRFGGNKV--IEKVLIANNGIAAVKCMRSIRRWSYEMFRNERAIRFVVMVTPEDLKANA 89 Query: 50 PHVRLADEAFALGGQTSAESYLDFAKILDAAAKSGANAIHPGYGFLAENADFAQAVIDAG 109 ++++AD + G + +Y + ILD A + A+ G+G +EN + ++ G Sbjct: 90 EYIKMADHYVPVPGGPNNNNYANVELILDIAKRIPVQAVWAGWGHASENPKLPELLLKNG 149 Query: 110 LIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPGTP------------------------ 145 + ++GP Q++ LGDK+ + +A A P +P + Sbjct: 150 IAFMGPPSQAMWALGDKIASSIVAQTAGIPTLPWSGSGLRVDWQENDFSKRILNVPQELY 209 Query: 146 --DPVKGADEVVAFAEEYGLPIAIKAAHGGGGKGMKVARTIDEIPELYESAVREATAAFG 203 VK D+ + AEE G P+ IKA+ GGGGKG++ D+ P L+ R+ A Sbjct: 210 EKGYVKDVDDGLQAAEEVGYPVMIKASEGGGGKGIRKVNNADDFPNLF----RQVQAEVP 265 Query: 204 RGECYVERYLDKPRHVEAQVIADQHGNVVVAGTRDCSLQRRYQKLVEEAPAPFLTDFQRK 263 +V R + RH+E Q++ADQ+GN + RDCS+QRR+QK++EEAPA T + Sbjct: 266 GSPIFVMRLAKQSRHLEVQILADQYGNAISLFGRDCSVQRRHQKIIEEAPATIATPAVFE 325 Query: 264 EIHDSAKRICKEAHYHGAGTVEYLVGQDGLISFLEVNTRLQVEHPVTEETAGIDLVLQQF 323 + A ++ K Y AGTVEYL QDG FLE+N RLQVEHP TE A ++L Q Sbjct: 326 HMEQCAVKLAKMVGYVSAGTVEYLYSQDGSFYFLELNPRLQVEHPCTEMVADVNLPAAQL 385 Query: 324 RIANGEKLDITED-----------------------PTPRGHAIEFRINGEDAGRNFLPA 360 +IA G L +D P PRGH I RI E+ F P+ Sbjct: 386 QIAMGIPLYRIKDIRMMYGVSPWGDSPIDFEDSAHVPCPRGHVIAARITSENPDEGFKPS 445 Query: 361 PGPVTKFHPPSGPGVRVDSGVETGSVIGGQFDSMLAKLIVHGADRAEALARARRALNEFG 420 G V + + S V V + DS G +R EA++ AL E Sbjct: 446 SGTVQELNFRSNKNVWGYFSVAAAGGLHEFADSQFGHCFSWGENREEAISNMVVALKELS 505 Query: 421 VEG-LATVIPFHRAVVSDPAFIGDANGFSVHTRWIE 455 + G T + + ++ +F + + T W++ Sbjct: 506 IRGDFRTTVEYLIKLLETESFQMNR----IDTGWLD 537 >3JRW-A nrPDB Length = 587 Score = 561 bits (1445), Expect = e-160, Method: Composition-based stats. Identities = 149/517 (28%), Positives = 230/517 (44%), Gaps = 72/517 (13%) Query: 1 MASHAGSRIARISKVLVANRGEIAVRVIRAARDAGLP--------SVAVYAEPD---AES 49 + G R+ I KVL+AN G AV+ +R+ R V P+ A + Sbjct: 47 VTRFGGDRV--IEKVLIANNGIAAVKCMRSIRRWAYEMFRNERAIRFVVMVTPEDLKANA 104 Query: 50 PHVRLADEAFALGGQTSAESYLDFAKILDAAAKSGANAIHPGYGFLAENADFAQAVIDAG 109 ++++AD + G + +Y + I+D A + A+ G+G +EN + + G Sbjct: 105 EYIKMADHYVPVPGGPNNNNYANVELIVDIAKRIPVQAVWAGWGHASENPKLPELLCKNG 164 Query: 110 LIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPGTP------------------------ 145 + ++GP +++ LGDK+ + +A Q P +P + Sbjct: 165 VAFLGPPSEAMWALGDKIASTVVAQTLQVPTLPWSGSGLTVEWTEDDLQQGKRISVPEDV 224 Query: 146 ---DPVKGADEVVAFAEEYGLPIAIKAAHGGGGKGMKVARTIDEIPELYESAVREATAAF 202 VK DE + AE G P+ IKA+ GGGGKG++ A + ++ P L+ R+ + Sbjct: 225 YDKGCVKDVDEGLEAAERIGFPLMIKASEGGGGKGIRKAESAEDFPILF----RQVQSEI 280 Query: 203 GRGECYVERYLDKPRHVEAQVIADQHGNVVVAGTRDCSLQRRYQKLVEEAPAPFLTDFQR 262 ++ + RH+E Q++ADQ+GN V RDCS+QRR+QK+VEEAPA Sbjct: 281 PGSPIFLMKLAQHARHLEVQILADQYGNAVSLFGRDCSIQRRHQKIVEEAPATIAPLAIF 340 Query: 263 KEIHDSAKRICKEAHYHGAGTVEYLVGQDGLISFLEVNTRLQVEHPVTEETAGIDLVLQQ 322 + + A R+ K Y AGTVEYL QDG FLE+N RLQVEHP TE A ++L Q Sbjct: 341 EFMEQCAIRLAKTVGYVSAGTVEYLYSQDGSFHFLELNPRLQVEHPCTEMIADVNLPAAQ 400 Query: 323 FRIANGEKLDITED-----------------------PTPRGHAIEFRINGEDAGRNFLP 359 +IA G L +D P RGH I RI E+ F P Sbjct: 401 LQIAMGVPLHRLKDIRLLYGESPWGVTPISFETPSNPPLARGHVIAARITSENPDEGFKP 460 Query: 360 APGPVTKFHPPSGPGVRVDSGVETGSVIGGQFDSMLAKLIVHGADRAEALARARRALNEF 419 + G V + + S V V + DS G +R EA++ AL E Sbjct: 461 SSGTVQELNFRSSKNVWGYFSVAATGGLHEFADSQFGHCFSWGENREEAISNMVVALKEL 520 Query: 420 GVEG-LATVIPFHRAVVSDPAFIGDANGFSVHTRWIE 455 + G T + + ++ +F + + T W++ Sbjct: 521 SIRGDFRTTVEYLINLLETESFQNN----DIDTGWLD 553 >1W93-A nrPDB Length = 553 Score = 537 bits (1384), Expect = e-153, Method: Composition-based stats. Identities = 145/524 (27%), Positives = 232/524 (44%), Gaps = 79/524 (15%) Query: 1 MASHAGSRIARISKVLVANRGEIAVRVIRAARDAGLPS---------VAVYAEPD--AES 49 + SH G + ISK+L+AN G AV+ IR+ R + VA+ D A + Sbjct: 37 VKSHGGHTV--ISKILIANNGIAAVKEIRSVRKWAYETFGDDRTVQFVAMATPEDLEANA 94 Query: 50 PHVRLADEAFALGGQTSAESYLDFAKILDAAAKSGANAIHPGYGFLAENADFAQAVIDAG 109 ++R+AD+ + G T+ +Y + I+D A ++ +A+ G+G +EN + + + Sbjct: 95 EYIRMADQYIEVPGGTNNNNYANVDLIVDIAERADVDAVWAGWGHASENPLLPEKLSQSK 154 Query: 110 --LIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPGTPDPVKGA---------------- 151 +I+IGP ++R LGDK+++ +A A+ P +P + V Sbjct: 155 RKVIFIGPPGNAMRSLGDKISSTIVAQSAKVPCIPWSGTGVDTVHVDEKTGLVSVDDDIY 214 Query: 152 --------DEVVAFAEEYGLPIAIKAAHGGGGKGMKVARTIDEIPELYESAVREATAAFG 203 ++ + A+ G P+ IKA+ GGGGKG++ ++ LY A E Sbjct: 215 QKGCCTSPEDGLQKAKRIGFPVMIKASEGGGGKGIRQVEREEDFIALYHQAANE----IP 270 Query: 204 RGECYVERYLDKPRHVEAQVIADQHGNVVVAGTRDCSLQRRYQKLVEEAPAPFLTDFQRK 263 ++ + + RH+E Q++ADQ+G + RDCS+QRR+QK++EEAP Sbjct: 271 GSPIFIMKLAGRARHLEVQLLADQYGTNISLFGRDCSVQRRHQKIIEEAPVTIAKAETFH 330 Query: 264 EIHDSAKRICKEAHYHGAGTVEYLVGQ-DGLISFLEVNTRLQVEHPVTEETAGIDLVLQQ 322 E+ +A R+ K Y AGTVEYL DG FLE+N RLQVEHP TE +G++L Q Sbjct: 331 EMEKAAVRLGKLVGYVSAGTVEYLYSHDDGKFYFLELNPRLQVEHPTTEMVSGVNLPAAQ 390 Query: 323 FRIANGEKLDITED------------------------------PTPRGHAIEFRINGED 352 +IA G + D P P+GH RI ED Sbjct: 391 LQIAMGIPMHRISDIRTLYGMNPHSASEIDFEFKTQDATKKQRRPIPKGHCTACRITSED 450 Query: 353 AGRNFLPAPGPVTKFHPPSGPGVRVDSGVETGSVIGGQFDSMLAKLIVHGADRAEALARA 412 F P+ G + + + S V V I DS + G +R + Sbjct: 451 PNDGFKPSGGTLHELNFRSSSNVWGYFSVGNNGNIHSFSDSQFGHIFAFGENRQASRKHM 510 Query: 413 RRALNEFGVEG-LATVIPFHRAVVSDPAFIGDANGFSVHTRWIE 455 AL E + G T + + ++ F + + T W++ Sbjct: 511 VVALKELSIRGDFRTTVEYLIKLLETEDFEDNT----ITTGWLD 550 >5H80-A nrPDB Length = 494 Score = 497 bits (1280), Expect = e-141, Method: Composition-based stats. Identities = 198/454 (43%), Positives = 271/454 (59%), Gaps = 19/454 (4%) Query: 14 KVLVANRGEIAVRVIRAARDAGLPSVAVYAEPDAESPHVRLADEAFALGGQTSAESYLDF 73 +VL+ANRGE+AVR+ RA G SVAVYA DA S HVR ADEA AL G+ +A +YLD Sbjct: 34 RVLIANRGEVAVRIERAVSALGWQSVAVYAPDDAGSLHVRRADEAVALSGRGAA-AYLDG 92 Query: 74 AKILDAAAKSGANAIHPGYGFLAENADFAQAVIDAGLIWIGPSPQSIRDLGDKVTARHIA 133 A +L A + A +HPGYGFL+ENADFA+A AGL+++GP P ++ GDK AR +A Sbjct: 93 AALLRVAQEHAATHVHPGYGFLSENADFARACAQAGLVFVGPDPDTLDLFGDKSRARGLA 152 Query: 134 ARAQAPLVPGTPDPVKGADEVVAFAE-EYGLPIAIKAAHGGGGKGMKVARTIDEIPELYE 192 R P++PGT +E AF + + G P+ +KA GGGG+GM+V R ++ +E Sbjct: 153 QRLGVPVIPGTDG-ATTLEEAAAFMQAQGGAPVMLKACSGGGGRGMRVVRQAGDLAAAFE 211 Query: 193 SAVREATAAFGRGECYVERYLDKPRHVEAQVIADQHGNVVVAGTRDCSLQRRYQKLVEEA 252 A REA A G+G+ Y ER +++ RH+E QV D +V RDC++QRR+QKL+E A Sbjct: 212 QASREARLAVGQGDLYAERLIERARHIEVQVAGDGQ-SVTHLWERDCTVQRRHQKLLEFA 270 Query: 253 PAPFLTDFQRKEIHDSAKRICKEAHYHGAGTVEYLVGQDGLISFLEVNTRLQVEHPVTEE 312 PAP L R + +A ++ +E Y GT E+LV G F+E N RLQVEH VTEE Sbjct: 271 PAPHLPQAVRTALIGAALQLAQEVKYRCLGTFEFLVTPGGDFYFIEANPRLQVEHTVTEE 330 Query: 313 TAGIDLVLQQFRIANGEKLD---ITEDPT----PRGHAIEFRINGEDAGRN--FLPAPGP 363 G DLV Q R+A GE L + P P G A++ R+N E G + G Sbjct: 331 WCGTDLVTAQLRLAAGETLTAVGLATQPADAAPPPGQAVQARVNMETLGADGQVHVGGGQ 390 Query: 364 VTKFHPPSGPGVRVDSGVETGSVIGGQFDSMLAKLIVHGADRAE--ALARARRALNEFGV 421 V F PP GPGVRVD+ V TG Q+D++LAK++VH D A L +A AL+EF + Sbjct: 391 VQTFTPPGGPGVRVDTFVTTGLTPSPQYDALLAKVVVHRRDAALPGLLRQAATALSEFQI 450 Query: 422 EGLATVIPFHRAVVSDPAFIGDANGFSVHTRWIE 455 G++T + F +A++ P D + + T W++ Sbjct: 451 AGVSTNLAFLQALLHHP----DVQHYELSTHWLD 480 >5KS8-A nrPDB Length = 405 Score = 351 bits (901), Expect = 4e-97, Method: Composition-based stats. Identities = 106/231 (45%), Positives = 151/231 (65%), Gaps = 1/231 (0%) Query: 213 LDKPRHVEAQVIADQHGNVVVAGTRDCSLQRRYQKLVEEAPAPFLTDFQRKEIHDSAKRI 272 + PRH+E QV+AD HGNV+ RDCS+QRR QKL+E AP+P L+ QR+ I + A + Sbjct: 135 VVNPRHIEVQVLADSHGNVIHLFERDCSIQRRNQKLIEIAPSPQLSKAQREYIGNLAVKA 194 Query: 273 CKEAHYHGAGTVEYLVGQDGLISFLEVNTRLQVEHPVTEETAGIDLVLQQFRIANGEKLD 332 K Y AGTVE+L+ D F+E+NTRLQVEH VTE+ GID+V +Q R+A+G++L Sbjct: 195 AKAVGYKNAGTVEFLLDSDNNFYFMEMNTRLQVEHTVTEQITGIDIVQEQIRVADGQRLQ 254 Query: 333 ITEDPTP-RGHAIEFRINGEDAGRNFLPAPGPVTKFHPPSGPGVRVDSGVETGSVIGGQF 391 + RG A+EFRIN ED +FLP+ G +T+++ P GPG+R+D+ + +G VI + Sbjct: 255 YKQSEVQYRGFAMEFRINAEDPKNDFLPSFGKITRYYAPGGPGIRMDAAMYSGYVIPPYY 314 Query: 392 DSMLAKLIVHGADRAEALARARRALNEFGVEGLATVIPFHRAVVSDPAFIG 442 DSM AKL V + + R RRALN+ V G+ T IP+++ ++ P F Sbjct: 315 DSMCAKLTVWALNWESVVERGRRALNDTVVYGVKTTIPYYQEILKHPDFRN 365 >6DGI-A nrPDB Length = 337 Score = 206 bits (523), Expect = 3e-53, Method: Composition-based stats. Identities = 53/228 (23%), Positives = 90/228 (39%), Gaps = 31/228 (13%) Query: 92 YGFLAENADFAQAVIDAGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVP------GTP 145 +GF E D + AG+ ++G P++ + +K+T++ P P TP Sbjct: 86 HGFPGETGDIQSMLELAGIPYLGCGPEASANSFNKITSKLWYDALDIPNTPYLFLTQNTP 145 Query: 146 DPVKGADEVVAFAEEYGLPIAIKAAHGGGGKGMKVARTIDEIPELYESAVREATAAFGRG 205 + A + +G I +KAA G G T D+I E AAFG Sbjct: 146 SSIDKAKQAFG---HWG-SIFVKAARQGSSVGCYKVTTEDQIAPAIE-------AAFGFS 194 Query: 206 ECYVERYLDKPRHVEA-------QVIADQHGNVVVAGTRDCSLQRR-----YQKLVEEAP 253 E + KPR +E ++ + G V+ S + + + + V EA Sbjct: 195 EQVLVEQAVKPRELEVSAYEMNGKLYISKPGEVIAPEGTFYSYEEKYSANSHARTVLEAE 254 Query: 254 APFLTDFQRKEIHDSAKRICKEAHYHGAGTVEYLVGQDGLISFLEVNT 301 LT+ ++ I A+R+ +++ + Q+G I EVNT Sbjct: 255 N--LTEKHKELIQTYAERVFIHMKLRHLSRIDFFLTQEGQIYLNEVNT 300 >5KS8-C nrPDB Length = 617 Score = 169 bits (428), Expect = 3e-42, Method: Composition-based stats. Identities = 56/162 (34%), Positives = 76/162 (46%), Gaps = 20/162 (12%) Query: 450 HTRWIETEWNNTI--EPF----TDGEPLDEDARPRQKVVVEIDGRRVEVSLPADLALSNG 503 H+R+ TE+N T+ E F T E+ RP V +DG EV + + Sbjct: 463 HSRFAPTEFNVTLHGETFHIKLTGSGHHGEEQRP---FYVSVDGVTEEVVVEILNEIEVS 519 Query: 504 GGCDPVGVIRRKPKP-----RKRGAHTGAAASGDAVTAPMQGTVVKFAVEEGQEVVAGDL 558 GG G +RK R R H G VT M GT+V V G +V AGD Sbjct: 520 GGGQSSGEAKRKASSAASSGRPRPTHAGC------VTTAMPGTIVDVKVNVGDKVSAGDA 573 Query: 559 VVVLEAMKMENPVTAHKDGTITGLAVEAGAAITQGTVLAEIK 600 V+V+EAMKMEN + A K G + + V+ G ++T L EI+ Sbjct: 574 VLVIEAMKMENEIQASKSGVVVAINVKKGDSVTPDEALLEIQ 615 >2CQY-A nrPDB Length = 108 Score = 119 bits (299), Expect = 3e-27, Method: Composition-based stats. Identities = 38/101 (37%), Positives = 62/101 (61%) Query: 119 SIRDLGDKVTARHIAARAQAPLVPGTPDPVKGADEVVAFAEEYGLPIAIKAAHGGGGKGM 178 S GDK+ ++ +A +A+ +PG VK A+E V A E G P+ IKA+ GGGGKGM Sbjct: 2 SSGSSGDKIESKLLAKKAEVNTIPGFDGVVKDAEEAVRIAREIGYPVMIKASAGGGGKGM 61 Query: 179 KVARTIDEIPELYESAVREATAAFGRGECYVERYLDKPRHV 219 ++A +E + + + +EA ++FG +E+++D PRH+ Sbjct: 62 RIAWDDEETRDGFRLSSQEAASSFGDDRLLIEKFIDNPRHI 102 >4C5A-A nrPDB Length = 330 Score = 101 bits (251), Expect = 1e-21, Method: Composition-based stats. Identities = 38/219 (17%), Positives = 76/219 (34%), Gaps = 17/219 (7%) Query: 92 YGFLAENADFAQAVIDAGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPG---TPDPV 148 +G E+ + GL + G + DK+ ++ + A P+ P T Sbjct: 87 HGRGGEDGTLQGMLELMGLPYTGSGVMASALSMDKLRSKLLWQGAGLPVAPWVALTRAEF 146 Query: 149 KG--ADEVVAFAEEYGLPIAIKAAHGGGGKGMKVARTIDEIPELYESAVREATAAFGRGE 206 + +D+ +A GLP+ +K + G GM + + + A + E Sbjct: 147 EKGLSDKQLAEISALGLPVIVKPSREGSSVGMSKVVAENALQDALRLAFQH------DEE 200 Query: 207 CYVERYLDKPRHVEAQVIADQ--HGNVVVAGTRDCSLQRRY--QKLVEEAPAPFLTDFQR 262 +E++L P ++ ++ + + +Y + PA L Q Sbjct: 201 VLIEKWLSGP-EFTVAILGEEILPSIRIQPSGTFYDYEAKYLSDETQYFCPA-GLEASQE 258 Query: 263 KEIHDSAKRICKEAHYHGAGTVEYLVGQDGLISFLEVNT 301 + + G G ++ ++ DG LE NT Sbjct: 259 ANLQALVLKAWTTLGCKGWGRIDVMLDSDGQFYLLEANT 297 >5D8D-A nrPDB Length = 308 Score = 98.2 bits (243), Expect = 9e-21, Method: Composition-based stats. Identities = 44/215 (20%), Positives = 73/215 (33%), Gaps = 14/215 (6%) Query: 92 YGFLAENADFAQAVIDAGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPGTPDPVKGA 151 +G E+ + + + G Q DKV + I + P P K Sbjct: 66 HGRGGEDGQIQGVLEWLNIPYTGTGVQGSAIGMDKVKTKQIWQGSDLPTAP-YRIITKET 124 Query: 152 DEVVAFAEEYGLPIAIKAAHGGGGKGMKVARTIDEIPELYESAVREATAAFGRGECYVER 211 D A E GLP+ IK H G GM ++ E A + E+ Sbjct: 125 DLDSVIA-ELGLPVIIKPVHEGSSVGMSKVEKAEDFAAAIEKATQH------DAVVMAEK 177 Query: 212 YLDKPRHVEAQVIADQHGNVVVAGT----RDCSLQRRYQKL-VEEAPAPFLTDFQRKEIH 266 ++ R + Q V+ + +YQ+ VE L++ + K++ Sbjct: 178 WITG-REFTISFLNGQPLPVIRLQPPADVAFYDYEAKYQRNDVEYGIPCGLSETEEKKLQ 236 Query: 267 DSAKRICKEAHYHGAGTVEYLVGQDGLISFLEVNT 301 R + G G ++ + + G LEVNT Sbjct: 237 ALCLRAFQAVGAEGWGRIDAMQDEQGNFWLLEVNT 271 >2I87-A nrPDB Length = 364 Score = 95.1 bits (235), Expect = 8e-20, Method: Composition-based stats. Identities = 37/230 (16%), Positives = 74/230 (32%), Gaps = 21/230 (9%) Query: 84 GANAIHPG-YGFLAENADFAQAVIDAGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVP 142 +A+ P +G E+ + ++G S DK+ + + P +P Sbjct: 87 PYDAVFPLLHGPNGEDGTIQGLFEVLDVPYVGNGVLSAASSMDKLVMKQLFEHRGLPQLP 146 Query: 143 GTPDPVKGADE-----VVAFAEEYGLPIAIKAAHGGGGKGMKVARTIDEIPELYESAVRE 197 ++ + ++ P+ +K A+ G G+ E+ E Sbjct: 147 YISFLRSEYEKYEHNILKLVNDKLNYPVFVKPANLGSSVGISKCNNEAELKEGI------ 200 Query: 198 ATAAFGRGECYVERYLDKPRHVEAQVIADQHGNVVVAGT-----RDCSLQRRYQ--KLVE 250 AF V R +E V+ + + G + +Y+ K+ Sbjct: 201 -KEAFQFDRKLVIEQGVNAREIEVAVLGNDYPEATWPGEVVKDVAFYDYKSKYKDGKVQL 259 Query: 251 EAPAPFLTDFQRKEIHDSAKRICKEAHYHGAGTVEYLVGQDGLISFLEVN 300 + PA L + + + + A K G ++ V +D I E N Sbjct: 260 QIPAD-LDEDVQLTLRNMALEAFKATDCSGLVRADFFVTEDNQIYINETN 308 >3I12-A nrPDB Length = 364 Score = 92.4 bits (228), Expect = 5e-19, Method: Composition-based stats. Identities = 51/274 (18%), Positives = 94/274 (34%), Gaps = 35/274 (12%) Query: 51 HVRLADEAFALGGQTSAESYLDFAK-----ILDAAAKSG---ANAIHP-GYGFLAENADF 101 +++ AD+ + + SA S +++A + I P +G L E+ Sbjct: 57 YLQNADDPAHIALRPSAISLAQVPGKHQHQLINAQNGQPLPTVDVIFPIVHGTLGEDGSL 116 Query: 102 AQAVIDAGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPGTPDPVKGADEVVAFAE-- 159 + A L ++G S DK A+ + A + P + +FAE Sbjct: 117 QGMLRVANLPFVGSDVLSSAACMDKDVAKRLLRDAGLNIAP-FITLTRTNRHAFSFAEVE 175 Query: 160 -EYGLPIAIKAAHGGGGKGMKVARTIDEIPELYESAVREATAAFGRGECYVERYLDKPRH 218 GLP+ +K A+ G G+ + + AF V K R Sbjct: 176 SRLGLPLFVKPANQGSSVGVSKVANEAQYQQA-------VALAFEFDHKVVVEQGIKGRE 228 Query: 219 VEAQVIADQHGNV-----VVAGTRDCSLQRRY------QKLVEEAPAPFLTDFQRKEIHD 267 +E V+ + + +V + + +Y Q +V PA + +I Sbjct: 229 IECAVLGNDNPQASTCGEIVLNSEFYAYDTKYIDDNGAQVVV---PA-QIPSEVNDKIRA 284 Query: 268 SAKRICKEAHYHGAGTVEYLVGQDGLISFLEVNT 301 A + + G V+ + D + E+NT Sbjct: 285 IAIQAYQTLGCAGMARVDVFLTADNEVVINEINT 318 >2FB9-A nrPDB Length = 322 Score = 92.0 bits (227), Expect = 7e-19, Method: Composition-based stats. Identities = 40/217 (18%), Positives = 76/217 (35%), Gaps = 20/217 (9%) Query: 92 YGFLAENADFAQAVIDAGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPGTPDPVKGA 151 +G E+ + G ++G + DK ++ + A+A P+VP Sbjct: 85 HGRFGEDGTVQGFLELLGKPYVGAGVAASALCMDKDLSKRVLAQAGVPVVPW-----VAV 139 Query: 152 DEVVAFAEEYGLPIAIKAAHGGGGKGMKVARTIDEIPELYESAVREATAAFGRGECYVER 211 + + P +K A+ G G+ ++ A R A VE+ Sbjct: 140 RKGEPPVVPFDPPFFVKPANTGSSVGISRVERFQDLEAALALAFRYDEKAV------VEK 193 Query: 212 YLDKPRHVEAQVIADQHGNVVVAGTR-----DCSLQRRYQ--KLVEEAPAPFLTDFQRKE 264 L R +E V+ + G G + +Y + PAP L ++ Sbjct: 194 ALSPVRELEVGVLGNVFGEASPVGEVRYEAPFYDYETKYTPGRAELLIPAP-LDPGTQET 252 Query: 265 IHDSAKRICKEAHYHGAGTVEYLVGQDGLISFLEVNT 301 + + A + K G V++ + +G + E+NT Sbjct: 253 VQELALKAYKVLGVRGMARVDFFLA-EGELYLNELNT 288 >1E4E-B nrPDB Length = 343 Score = 89.7 bits (221), Expect = 3e-18, Method: Composition-based stats. Identities = 48/224 (21%), Positives = 80/224 (35%), Gaps = 28/224 (12%) Query: 92 YGFLAENADFAQAVIDAGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPGTPDPVKGA 151 +G E+ +G+ ++G QS DK +A A TP Sbjct: 99 HGKSGEDGSIQGLFELSGIPFVGCDIQSSAICMDKSLTYIVAKNAGI----ATPAFWVIN 154 Query: 152 DEVVAFAEEYGLPIAIKAAHGGGGKGMKVARTIDEIPELYESAVREATAAFGRGECYVER 211 + A + P+ +K A G G+K + DE+ ESA + + +E+ Sbjct: 155 KDDRPVAATFTYPVFVKPARSGSSFGVKKVNSADELDYAIESARQY------DSKILIEQ 208 Query: 212 YLDKPRHVEAQVIADQHGNVVVAGTRD-----CSLQRRYQKL---------VEEAPAPFL 257 + E + +V G D + R +Q++ V PA L Sbjct: 209 AVSG---CEVGCAVLGNSAALVVGEVDQIRLQYGIFRIHQEVEPEKGSENAVITVPAD-L 264 Query: 258 TDFQRKEIHDSAKRICKEAHYHGAGTVEYLVGQDGLISFLEVNT 301 + +R I ++ K+I K G V+ + G I EVNT Sbjct: 265 SAEERGRIQETVKKIYKTLGCRGLARVDMFLQDRGRIVLNEVNT 308 >1A6X-A nrPDB Length = 87 Score = 89.7 bits (221), Expect = 3e-18, Method: Composition-based stats. Identities = 31/85 (36%), Positives = 43/85 (50%), Gaps = 7/85 (8%) Query: 523 AHTGAAASGDAVTAPMQGTV-------VKFAVEEGQEVVAGDLVVVLEAMKMENPVTAHK 575 A A SG V +PM GT K +E GQ+V GD + ++EAMKM N + A K Sbjct: 3 APAAAEISGHIVRSPMVGTFYRTPSPDAKAFIEVGQKVNVGDTLCIVEAMKMMNQIEADK 62 Query: 576 DGTITGLAVEAGAAITQGTVLAEIK 600 GT+ + VE+G + L I+ Sbjct: 63 SGTVKAILVESGQPVEFDEPLVVIE 87 >4HR7-B nrPDB Length = 176 Score = 87.8 bits (216), Expect = 1e-17, Method: Composition-based stats. Identities = 31/85 (36%), Positives = 43/85 (50%), Gaps = 7/85 (8%) Query: 523 AHTGAAASGDAVTAPMQGTV-------VKFAVEEGQEVVAGDLVVVLEAMKMENPVTAHK 575 A A SG V +PM GT K +E GQ+V GD + ++EAMKM N + A K Sbjct: 92 APAAAEISGHIVRSPMVGTFYRTPSPDAKAFIEVGQKVNVGDTLCIVEAMKMMNQIEADK 151 Query: 576 DGTITGLAVEAGAAITQGTVLAEIK 600 GT+ + VE+G + L I+ Sbjct: 152 SGTVKAILVESGQPVEFDEPLVVIE 176 >5CSA-A nrPDB Length = 932 Score = 87.4 bits (215), Expect = 2e-17, Method: Composition-based stats. Identities = 21/64 (32%), Positives = 36/64 (56%), Gaps = 1/64 (1%) Query: 534 VTAPMQGTVVKFAVEEGQEVVAGDLVVVLEAMKMENPVTAHKDGTITGLAVEAGAAITQG 593 + P G +VKF VE G+ ++ G +E MKM+ P+ + ++G I L + G+ I G Sbjct: 135 LRTPSPGKLVKFLVENGEHIIKGQPYAEIEVMKMQMPLVSQENG-IVQLLKQPGSTIVAG 193 Query: 594 TVLA 597 ++A Sbjct: 194 DIMA 197 >3K3P-A nrPDB Length = 383 Score = 86.6 bits (213), Expect = 3e-17, Method: Composition-based stats. Identities = 40/224 (17%), Positives = 83/224 (37%), Gaps = 26/224 (11%) Query: 92 YGFLAENADFAQAVIDAGLIWIGPSPQSIRDLGDKVT-------ARHIAARAQAPLVPGT 144 +G + E+ + + ++G + S DK+T A I A L+ G Sbjct: 128 HGPMGEDGSIQGFLEVLKMPYVGTNILSSSVAMDKITTNQVLESATTIPQVAYVALIEGE 187 Query: 145 PDPVKGADEVVAFAEEYGLPIAIKAAHGGGGKGMKVARTIDEIPELYESAVREATAAFGR 204 P K A+ E+ P+ +K A+ G G+ A ++ + A++ Sbjct: 188 PLESKLAE----VEEKLIYPVFVKPANMGSSVGISKAENRTDLKQAIALALKY------D 237 Query: 205 GECYVERYLDKPRHVEAQVIADQHGNVVVAGT-----RDCSLQRRY--QKLVEEAPAPFL 257 +E+ +D R +E ++ + + G + +Y K+ PA + Sbjct: 238 SRVLIEQGVD-AREIEVGILGNTDVKTTLPGEIVKDVAFYDYEAKYIDNKITMAIPAE-I 295 Query: 258 TDFQRKEIHDSAKRICKEAHYHGAGTVEYLVGQDGLISFLEVNT 301 +++ D A + G ++ + +DG + E+NT Sbjct: 296 DPVIVEKMRDYAATAFRTLGCCGLSRCDFFLTEDGKVYLNELNT 339 >5BPF-A nrPDB Length = 306 Score = 85.9 bits (211), Expect = 5e-17, Method: Composition-based stats. Identities = 41/219 (18%), Positives = 77/219 (35%), Gaps = 17/219 (7%) Query: 92 YGFLAENADFAQAVIDAGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPG-----TPD 146 +G E+ + L + G + DK+ + + P+ P Sbjct: 63 HGRGGEDGTLQGVLEFLQLPYTGSGVMASALTMDKLRTKLVWQALGLPISPYVALNRQQF 122 Query: 147 PVKGADEVVAFAEEYGLPIAIKAAHGGGGKGMKVARTIDEIPELYESAVREATAAFGRGE 206 +E+VA + GLP+ +K +H G GM E+ + A + + Sbjct: 123 ETLSPEELVACVAKLGLPLIVKPSHEGSSVGMSKVDHASELQKALVEAFQH------DSD 176 Query: 207 CYVERYLDKPRHVEAQVIADQ--HGNVVVAGTRDCSLQRRY--QKLVEEAPAPFLTDFQR 262 +E++L P ++ D+ + +Y K P+ L+D Sbjct: 177 VLIEKWLSGP-EFTVAILGDEVLPSIRIQPPGVFYDYDAKYLSDKTQYFCPS-GLSDESE 234 Query: 263 KEIHDSAKRICKEAHYHGAGTVEYLVGQDGLISFLEVNT 301 +++ A + G G V+ + +DG LEVNT Sbjct: 235 QQLAALALQAYHALDCSGWGRVDVMQDRDGHFYLLEVNT 273 >3AW8-A nrPDB Length = 369 Score = 85.9 bits (211), Expect = 5e-17, Method: Composition-based stats. Identities = 58/262 (22%), Positives = 95/262 (36%), Gaps = 24/262 (9%) Query: 97 ENADFAQAVIDAGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPGTPDPVKGADEVVA 156 EN A G + + P +++ D++ + P P P V G +++ Sbjct: 68 ENVPVEAARRLEGRLPLYPPAKALEVAQDRLREKTFFQGLGVPTPPFHP--VDGPEDLEE 125 Query: 157 FAEEYGLPIAIKAAHGG-GGKGMKVARTIDEIPELYESAVREATAAFGRGECYVERYLDK 215 + GLP +K GG GKG + RT +E EA A G +E ++ Sbjct: 126 GLKRVGLPALLKTRRGGYDGKGQALVRTEEE--------ALEALKALGGRGLILEGFVPF 177 Query: 216 PRHVEAQVIADQHGNV-VVAGTRDCSLQRRYQKLVEE---APAPFLTDFQRKEIHDSAKR 271 R V + + G V ++ R+ + APAP ++ +K+ A R Sbjct: 178 DREVSLLAVRGRTGEVAFYPL-----VENRHWGGILRLSLAPAPGASEALQKKAEAYALR 232 Query: 272 ICKEAHYHGAGTVEYLVGQDGLISFLEVNTRLQVEHPVTEETAGIDLVLQQFRIANGEKL 331 + Y G +E+ + + F E+ R+ T E A R G L Sbjct: 233 AMEALDYVGVLALEFFQVGE-ELLFNEMAPRVHNSGHWTIEGAETSQFENHLRAVLGLPL 291 Query: 332 DITEDPTPRGHAIEFRINGEDA 353 T PRG + + GE Sbjct: 292 GST---APRGQSAMVNLIGEKP 310 >4EG0-A nrPDB Length = 317 Score = 85.5 bits (210), Expect = 6e-17, Method: Composition-based stats. Identities = 49/226 (21%), Positives = 77/226 (34%), Gaps = 24/226 (10%) Query: 86 NAIHPGYGFLAENADFAQAVIDAGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPGTP 145 NA+H GYG EN A+ G+ + G DK + + + P P Sbjct: 71 NALHGGYG---ENGQIQGALDFYGIRYTGSGVLGSALGLDKFRTKLVWQQTGVPTPP-FE 126 Query: 146 DPVKGADEVVA---FAEEYGLPIAIKAAHGGGGKGMKVARTIDEIPELYESAVREATAAF 202 ++G D + GLP+ +K A G + +T D +P AA Sbjct: 127 TVMRGDDYAARATDIVAKLGLPLFVKPASEGSSVAVLKVKTADALPAALS------EAAT 180 Query: 203 GRGECYVERYLDKPRHVEAQVIADQ--HGNVVVAGTRDCSLQRRY-----QKLVEEAPAP 255 VE+ ++ A + D +V +Y Q L+ Sbjct: 181 HDKIVIVEKSIEGGGEYTACIAGDLDLPLIKIVPAGEFYDYHAKYVANDTQYLI----PC 236 Query: 256 FLTDFQRKEIHDSAKRICKEAHYHGAGTVEYLVGQDGLISFLEVNT 301 L Q E+ A+R G ++++ G FLEVNT Sbjct: 237 GLPAEQETELKRIARRAFDVLGCTDWGRADFMLDAAGNAYFLEVNT 282 >4EGJ-A nrPDB Length = 334 Score = 82.8 bits (203), Expect = 4e-16, Method: Composition-based stats. Identities = 48/225 (21%), Positives = 77/225 (34%), Gaps = 22/225 (9%) Query: 86 NAIHPGYGFLAENADFAQAVIDAGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPGTP 145 NA+H GYG EN A+ G+ + G DK + + + P P Sbjct: 88 NALHGGYG---ENGQIQGALDFYGIRYTGSGVLGSALGLDKFRTKLVWQQLGIPTPPFEA 144 Query: 146 DPVKGADEVVA--FAEEYGLPIAIKAAHGGGGKGMKVARTIDEIPELYESAVREATAAFG 203 E A + GLP+ +K A G + ++ D +P AV+ Sbjct: 145 VLRGDDYEARAKEIVAKLGLPLFVKPASEGSSVAVIKVKSADALPAALIEAVKF------ 198 Query: 204 RGECYVERYLDKPRHVEAQVIA--DQHGNVVVAGTRDCSLQRRY-----QKLVEEAPAPF 256 VE+ ++ A + D +V +Y Q L+ Sbjct: 199 DRIVVVEKSIEGGGEYTACIAGNLDLPVIRIVPAGEFYDYHAKYIANDTQYLI----PCG 254 Query: 257 LTDFQRKEIHDSAKRICKEAHYHGAGTVEYLVGQDGLISFLEVNT 301 LT + + A+R G ++++ DG FLEVNT Sbjct: 255 LTADEEARLKVLARRAFDVLGCTDWGRADFMLDADGNPYFLEVNT 299 >4FU0-A nrPDB Length = 357 Score = 82.0 bits (201), Expect = 6e-16, Method: Composition-based stats. Identities = 48/255 (18%), Positives = 76/255 (29%), Gaps = 25/255 (9%) Query: 59 FALGGQTSAESYLDFAKILDAAAKSGANAIHPG-YGFLAENADFAQAVIDAGLIWIGPSP 117 + S + +L+ A D + + P +G E+ AG+ +G Sbjct: 74 VVVSQNRSVKGFLEIAS--DKYRIIKVDLVFPVLHGKNGEDGTLQGIFELAGIPVVGCDT 131 Query: 118 QSIRDLGDKVTARHIAARAQAPLVPGTPDPVKGADEV--VAFAEEYGLPIAIKAAHGGGG 175 S DK A + + A VP + + +E P+ IK G Sbjct: 132 LSSALCMDKDRAHKLVSLAGIS-VPKSVTFKRFNEEAAMKEIEANLTYPLFIKPVRAGSS 190 Query: 176 KGMKVARTIDEIPELYESAVREATAAFGRGECYVERYLDKPRHVEAQVIADQH---GNV- 231 G+ E+ E AF + V V+ G V Sbjct: 191 FGITKVIEKQELDAAIEL-------AFEHDTEVIVEETINGFEVGCAVLGIDELIVGRVD 243 Query: 232 -VVAGTRDCSLQRRY----QKLVEEAPAPFLTDFQRKEIHDSAKRICKEAHYHGAGTVEY 286 + + +Y K+ A + K I ++A I K G V+ Sbjct: 244 EIELSSGFFDYTEKYTLKSSKIYMPA---RIDAEAEKRIQEAAVTIYKALGCSGFSRVDM 300 Query: 287 LVGQDGLISFLEVNT 301 G I F EVNT Sbjct: 301 FYTPSGEIVFNEVNT 315 >3LWB-A nrPDB Length = 373 Score = 79.7 bits (195), Expect = 4e-15, Method: Composition-based stats. Identities = 48/233 (20%), Positives = 82/233 (35%), Gaps = 25/233 (10%) Query: 85 ANAIHPG-YGFLAENADFAQAVIDAGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPG 143 + + P +G E+ + AG+ ++G + DK + + A P+ Sbjct: 110 VDVVFPVLHGPYGEDGTIQGLLELAGVPYVGAGVLASAVGMDKEFTKKLLAADGLPVGAY 169 Query: 144 TPDPVKGADEVVAFAEEYGLPIAIKAAHGGGGKGMKVARTIDEIPELYESAVREATAAFG 203 + E GLP+ +K A GG G+ + D++P A R Sbjct: 170 AVLRPPRSTLHRQECERLGLPVFVKPARGGSSIGVSRVSSWDQLPAAVARARRH------ 223 Query: 204 RGECYVERYLDKPRHVEAQVI--------ADQHGNVVVAG--TRDCSLQRRYQKLVEEA- 252 + R +E V+ A G + VAG R+ S K +++A Sbjct: 224 -DPKVIVEAAISGRELECGVLEMPDGTLEASTLGEIRVAGVRGREDSFYDFATKYLDDAA 282 Query: 253 ----PAPFLTDFQRKEIHDSAKRICKEAHYHGAGTVEYLVGQDGLISFLEVNT 301 PA + D + I A R G V++ + DG + E+NT Sbjct: 283 ELDVPAK-VDDQVAEAIRQLAIRAFAAIDCRGLARVDFFLTDDGPV-INEINT 333 >3E5N-A nrPDB Length = 386 Score = 76.2 bits (186), Expect = 3e-14, Method: Composition-based stats. Identities = 56/279 (20%), Positives = 98/279 (35%), Gaps = 30/279 (10%) Query: 85 ANAIHP-GYGFLAENADFAQAVIDAGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPG 143 + + P +G L E+ + A L ++G DK A+ + A+ + P Sbjct: 118 IDVVFPIVHGTLGEDGSLQGLLRMANLPFVGSGVLGSAVAMDKDMAKRVLRDARLAVAPF 177 Query: 144 --TPDPVKGADEVVAFAEEYGLPIAIKAAHGGGGKGMKVARTIDEIPELYESAVREATAA 201 +V + GLP+ +K A+ G G+ RT D A+ Sbjct: 178 VCFDRHTAAHADVDTLIAQLGLPLFVKPANQGSSVGVSQVRTADAFAAALALALA----- 232 Query: 202 FGRGECYVERYLDKPRHVEAQVIADQ--HGNV---VVAGTRDCSLQRRY--QKLVEEAPA 254 + R +E V+ + H +V VV S +Y + E Sbjct: 233 --YDHKVLVEAAVAGREIECAVLGNAVPHASVCGEVVVHDAFYSYATKYISEHGAEIVIP 290 Query: 255 PFLTDFQRKEIHDSAKRICKEAHYHGAGTVEYLVGQDGLISFLEVN-----TRLQVEHPV 309 + ++ I A + + G V+ + DG I EVN TR+ V +P Sbjct: 291 ADIDAQTQQRIQQIAVQAYQALGCAGMARVDVFLCADGRIVINEVNTLPGFTRISV-YPK 349 Query: 310 TEETAGID---LVLQQFRIANGEKLDITEDPTPRGHAIE 345 + +G+D L+ + +A L+ D A+E Sbjct: 350 LWQASGLDYRGLITRLIELA----LERHTDDQLLRSAVE 384 >3ORR-A nrPDB Length = 377 Score = 76.2 bits (186), Expect = 4e-14, Method: Composition-based stats. Identities = 55/279 (19%), Positives = 93/279 (33%), Gaps = 38/279 (13%) Query: 29 RAARDAGLPSVAVYAEPDAESPHVRLADEAFALGGQTSAESYLDFAKILDAAAKSGANAI 88 ++A+ G V + D +V A E Y D + K Sbjct: 29 QSAQKMGYKVVVLDPSEDCPCRYV--AHEFI-------QAKYDDEKALNQLGQKCDVIT- 78 Query: 89 HPGYGFLAENADFAQA---VIDAGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPGTP 145 Y F EN Q + Q+I+ L D++T + A +VP Sbjct: 79 ---YEF--ENISAQQLKLLCEKYNIP---QGYQAIQLLQDRLTEKETLKSAGTKVVPFI- 129 Query: 146 DPVKGADEVVAFAEEYGLPIAIKAAHGG-GGKGMKVARTIDEIPELYESAVREATAAFGR 204 VK + ++ E G P +K GG GKG + ++ E ++ Sbjct: 130 -SVKESTDIDKAIETLGYPFIVKTRFGGYDGKGQVLINNEKDLQEGFKLIET-------- 180 Query: 205 GECYVERYLDKPRHVEAQVIADQHGNVVVAGTRDCSLQR-RYQKLVEEAPAPFLTDFQRK 263 EC E+YL+ + V V GN LQ ++ + + Sbjct: 181 SECVAEKYLNIKKEVSLTV---TRGNNNQI--TFFPLQENEHRNQILFKTIVPARIDKTA 235 Query: 264 EIHDSAKRICKEAHYHGAGTVEYLVGQDGLISFLEVNTR 302 E + +I + H+ G TVE+ + + + E+ R Sbjct: 236 EAKEQVNKIIQSIHFIGTFTVEFFIDSNNQLYVNEIAPR 274 >3TQT-A nrPDB Length = 372 Score = 76.2 bits (186), Expect = 4e-14, Method: Composition-based stats. Identities = 39/233 (16%), Positives = 77/233 (33%), Gaps = 20/233 (8%) Query: 81 AKSGANAIHPG-YGFLAENADFAQAVIDAGLIWIGPSPQSIRDLGDKVTARHIAARAQAP 139 + A+ + P +G E+ + L ++G + QS +K + + P Sbjct: 95 RRYSADCVFPMVHGTQGEDGALQGLLELLNLPYVGANVQSSAVCMEKDLTKTVLRAGGIP 154 Query: 140 LVPGTPDPVKGADEVV--AFAEEYGLP-IAIKAAHGGGGKGMKVARTIDEIPELYESAVR 196 +V + A E V + +G + +KA G +T E + Sbjct: 155 VVDWHTLSPRDATEGVYQRLLDRWGTSELFVKAVSLGSSVATLPVKTETEFTKA------ 208 Query: 197 EATAAFGRGECYVERYLDKPRHVEAQVIADQ------HGNVVVAGTRDCSLQRRY--QKL 248 F + + + R +E V+ + G ++ S +Y Sbjct: 209 -VKEVFRYDDRLMVEPRIRGREIECAVLGNGAPKASLPGEII-PHHDYYSYDAKYLDPNG 266 Query: 249 VEEAPAPFLTDFQRKEIHDSAKRICKEAHYHGAGTVEYLVGQDGLISFLEVNT 301 + L++ K+I A K H G V++ V + + E+NT Sbjct: 267 ATTTTSVDLSESVTKQIQQIAIDAFKMVHCSGMARVDFFVTPNNKVLVNEINT 319 >5NRH-A nrPDB Length = 312 Score = 74.3 bits (181), Expect = 1e-13, Method: Composition-based stats. Identities = 47/226 (20%), Positives = 79/226 (34%), Gaps = 24/226 (10%) Query: 86 NAIHPGYGFLAENADFAQAVIDAGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPGTP 145 NA+H GYG EN A+ G+ + G DK + + + P P Sbjct: 67 NALHGGYG---ENGQIQGALDFYGIRYTGSGVLGSALGLDKFRTKLVWQQTGIPTPP-FE 122 Query: 146 DPVKGADEVVA---FAEEYGLPIAIKAAHGGGGKGMKVARTIDEIPELYESAVREATAAF 202 ++G D + G+P+ +K A G ++ ++ D +P E A + Sbjct: 123 TVMRGDDYAARAQDIVAKLGVPLFVKPASEGSSVAVEKVKSADALPAALEEAAKH----- 177 Query: 203 GRGECYVERYLDKPRHVEAQVIA--DQHGNVVVAGTRDCSLQRRY-----QKLVEEAPAP 255 VE+ ++ A + A D +V +Y Q L+ Sbjct: 178 -DKIVIVEKSIEGGGEYTACIAADLDLPLIRIVPAGEFYDYHAKYIANDTQYLI----PC 232 Query: 256 FLTDFQRKEIHDSAKRICKEAHYHGAGTVEYLVGQDGLISFLEVNT 301 L + E A+R G ++++ G FLEVNT Sbjct: 233 GLDAAKEAEFKRIARRAFDVLGCTDWGRADFMLDAAGNPYFLEVNT 278 >3QFF-A nrPDB Length = 389 Score = 74.3 bits (181), Expect = 1e-13, Method: Composition-based stats. Identities = 60/276 (21%), Positives = 99/276 (35%), Gaps = 32/276 (11%) Query: 30 AARDAGLPSVAVYAEPDAESPHVRLADEAFALGGQTSAESYLDFAKILDAAAKSGANAIH 89 AA++ G + +P SP ++AD SY D I A S Sbjct: 32 AAKEMGYKIAVL--DPTKNSPCAQVADIEI-------VASYDDLKAIQHLAEISDVVT-- 80 Query: 90 PGYGFLAENADFAQAVIDAGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPGTPDPVK 149 Y F EN D+ ++ Q + ++ T ++ +A P+ T V+ Sbjct: 81 --YEF--ENIDYRCLQWLEKHAYLPQGSQLLSKTQNRFTEKNAIEKAGLPV--ATYRLVQ 134 Query: 150 GADEVVAFAEEYGLPIAIKAAHGG-GGKGMKVARTIDEIPELYESAVREATAAFGRGECY 208 +++ E P +K GG GKG V R+ ++ E + A EC Sbjct: 135 NQEQLTEAIAELSYPSVLKTTTGGYDGKGQVVLRSEADVDEARKLANA--------AECI 186 Query: 209 VERYLDKPRHVEAQVIADQHGN--VVVAGTRDCSLQRRYQKLVEEAPAPFLTDFQRKEIH 266 +E+++ + V VI G V ++ +V PA +T+ ++ Sbjct: 187 LEKWVPFEKEVSVIVIRSVSGETKVFPVAENIHVNNILHESIV---PA-RITEELSQKAI 242 Query: 267 DSAKRICKEAHYHGAGTVEYLVGQDGLISFLEVNTR 302 AK + E G VE DG I E+ R Sbjct: 243 AYAKVLADELELVGTLAVEMFATADGEIYINELAPR 278 >2YW2-A nrPDB Length = 424 Score = 73.5 bits (179), Expect = 2e-13, Method: Composition-based stats. Identities = 65/346 (18%), Positives = 120/346 (34%), Gaps = 47/346 (13%) Query: 106 IDAGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPGTPDPVKGADEVVAFAEEYGLPI 165 GL GP+ ++ + G K A+ + P + ++ + E+ G PI Sbjct: 83 EKRGLKIFGPNKEAAKLEGSKAFAKTFMKKYGIPT--ARYEVFTDFEKAKEYVEKVGAPI 140 Query: 166 AIKAAHGGGGKGMKVARTIDEIPELYESAVREATAAFGRGECYVERYLDKPRHVEAQVIA 225 +KA GKG V T+++ E + + + +E +L+ V+ Sbjct: 141 VVKADGLAAGKGAVVCETVEKAIETLDRFLNKKIFGKSSERVVIEEFLEG-EEASYIVMI 199 Query: 226 DQHGNVVVAGTRDCSLQRRYQKLVEE------------APAPFLTDFQ----RKEIHDSA 269 + V + ++D +++L++E +P P + + R+EI + Sbjct: 200 NGDRYVPLPTSQD------HKRLLDEDKGPNTGGMGAYSPTPVINEEVEKRIREEIVERV 253 Query: 270 KRICKEAH--YHGAGTVEYLVGQDGLISFLEVNTRL-QVEHPVTEETAGIDLVLQQFRIA 326 + KE Y G ++ ++G LE N RL E D + Sbjct: 254 IKGLKEEGIYYRGFLYAGLMITKEGP-KVLEFNVRLGDPEAQPILMRVKNDFLETLLNFY 312 Query: 327 NGEKLDITEDPTPR-GHAIEFRINGEDAGR-------NFLPAPGPVTKFHPPSGPGVRVD 378 G+ + I ED + R E ++L + V FH G + Sbjct: 313 EGKDVHIKEDERYALDVVLASRGYPEKPETGKIIHGLDYLKSMEDVVVFHA--GTKKEGN 370 Query: 379 SGVETGSVIGGQFDSMLAKLIVHGADRAEALARARRALNEFGVEGL 424 V +G + + +G EA RA A+ EG+ Sbjct: 371 FTVTSGGRV--------LNVCAYGKTLKEAKERAYEAIRYVCFEGM 408 >3AX6-A nrPDB Length = 380 Score = 73.5 bits (179), Expect = 2e-13, Method: Composition-based stats. Identities = 76/397 (19%), Positives = 129/397 (32%), Gaps = 52/397 (13%) Query: 31 ARDAGLPSVAVYAEPDAESPHVRLADEAFALGGQTSAESYLDFAKILDAAAKSGANAIHP 90 A+ G + + P + + V ADE G + D +I D S Sbjct: 20 AKKMGFYVIVLDPTPRSPAGQV--ADEQIVAG-------FFDSERIEDLVKGSDVTT--- 67 Query: 91 GYGFLAENADFA--QAVIDAGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPGTPDPV 148 + E+ D + + + G I PSP ++ + DK + + P VP V Sbjct: 68 ---YDLEHIDVQTLKKLYNEGYK-IHPSPYTLEIIQDKFVQKEFLKKNGIP-VPEYK-LV 121 Query: 149 KGADEVVAFAEEYGLPIAIKAAHGG-GGKGMKVARTIDEIPELYESAVREATAAFGRGEC 207 K + V E+G P+ KA GG G+G+ + + ++ + GE Sbjct: 122 KDLESDV---REFGFPVVQKARKGGYDGRGVFIIKNEKDLENAIK------------GET 166 Query: 208 YVERYLDKPRHVEAQVIADQHGNVV-VAGTRDCSLQRRYQKLVEEAPAPFLTDFQR--KE 264 Y+E +++ + + V ++ G + + APA + + +E Sbjct: 167 YLEEFVEIEKELAVMVARNEKGEIACYPVVEMYFDEDANICDTVIAPARIEEKYSKIARE 226 Query: 265 IHDSAKRICKEAHYHGAGTVEYLVGQDGLISFLEVNTRLQVEHPVTEETAGIDLVLQQFR 324 I S + G +E + + G I E+ R T E Q R Sbjct: 227 IATSVVEALEGVGIFG---IEMFLTKQGEILVNEIAPRPHNSGHYTIEACVTSQFEQHIR 283 Query: 325 IANGEKLDITEDPTPRGHAIEFRINGEDAGRNFLPAPGPVTKFHPPSGPGVRVDSGVETG 384 L TE P A+ + GE+ PA + + G + Sbjct: 284 AIMNLPLGSTELLIP---AVMVNLLGEEGYYG-KPALIGLEEALAIEGLSL----HFYGK 335 Query: 385 SVIGGQFDSMLAKLIVHGADRAEALARARRALNEFGV 421 + V D AL +A RA V Sbjct: 336 KETRPY--RKMGHFTVVDRDVERALEKALRAKKILKV 370 >1EHI-A nrPDB Length = 377 Score = 73.2 bits (178), Expect = 3e-13, Method: Composition-based stats. Identities = 42/248 (16%), Positives = 79/248 (31%), Gaps = 29/248 (11%) Query: 73 FAKILDAAAKSGANAIHPG-YGFLAENADFAQAVIDAGLIWIGPSPQSIRDLGDKVTARH 131 A+I + + P +G L E+ ++G + DK + Sbjct: 82 LARIHALKSAGDFDIFFPVVHGNLGEDGTLQGLFKLLDKPYVGAPLRGHAVSFDKALTKE 141 Query: 132 IAARAQAPLVPGTPDPVKGADEVV-----AFAEEYGLPIAIKAAHGGGGKGMKVARTIDE 186 + + T V + E G + +KAA+ G G+ +E Sbjct: 142 L---LTVNGIRNTKYIVVDPESANNWSWDKIVAELGNIVFVKAANQGSSVGISRVTNAEE 198 Query: 187 IPELYESAVREATAAFGRGECYVERYLDKPRHVEAQVIADQHGNVVVAGTRDCSLQ---- 242 E + + + +E ++ R +E VI + V G Q Sbjct: 199 YTEALSDSFQY------DYKVLIEEAVNGARELEVGVIGNDQPLVSEIGAHTVPNQGSGD 252 Query: 243 ---RRYQKLVEEA------PAPFLTDFQRKEIHDSAKRICKEAHYHGAGTVEYLVGQDGL 293 K V+ + PA L+ KE+ A K + G +++L+ ++ + Sbjct: 253 GWYDYNNKFVDNSAVHFQIPA-QLSPEVTKEVKQMALDAYKVLNLRGEARMDFLLDENNV 311 Query: 294 ISFLEVNT 301 E NT Sbjct: 312 PYLGEPNT 319 >3R5X-A nrPDB Length = 307 Score = 70.1 bits (170), Expect = 3e-12, Method: Composition-based stats. Identities = 39/217 (17%), Positives = 77/217 (35%), Gaps = 14/217 (6%) Query: 87 AIHPGYGFLAENADFAQAVIDAGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPGTPD 146 A+H YG E+ + G+ + G + S DK ++ I P + Sbjct: 62 ALHGKYG---EDGTVQGTLESLGIPYSGSNMLSSGICMDKNISKKILRYEGIET-PDWIE 117 Query: 147 PVKGADEVVAFAEEYGLPIAIKAAHGGGGKGMKVARTIDEIPELYESAVREATAAFGRGE 206 K D ++ G P+ +K GG G+K+ DE+ + E+ E Sbjct: 118 LTKMEDLNFDELDKLGFPLVVKPNSGGSSVGVKIVYDKDELISMLETVFEW------DSE 171 Query: 207 CYVERYLDKPRHVEAQVIADQHGNVVVA--GTRDCSLQRRYQKLVEEAPAPFLTDFQRKE 264 +E+Y+ K + + + ++ +Y L ++ Sbjct: 172 VVIEKYI-KGEEITCSIFDGKQLPIISIRHAAEFFDYNAKYDDASTIEEVIELPAELKER 230 Query: 265 IHDSAKRICKEAHYHGAGTVEYLVGQDGLISFLEVNT 301 ++ ++ K V+ +V +DG+ +EVNT Sbjct: 231 VNKASLACYKALKCSVYARVDMMV-KDGIPYVMEVNT 266 >4E4T-A nrPDB Length = 419 Score = 66.2 bits (160), Expect = 4e-11, Method: Composition-based stats. Identities = 57/262 (21%), Positives = 86/262 (32%), Gaps = 30/262 (11%) Query: 97 ENADFAQAVIDAGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPGTP-DPVKGADEVV 155 EN A A ++ P+ + + D++ + + P+ P + + Sbjct: 105 ENVPAASLDFLARTTFVAPAGRCVAVAQDRIAEKRFIEASGVPVAPHVVIESAAALAALD 164 Query: 156 AFAEEYGLPIAIKAAHGG-GGKGMKVARTIDEIPELYESAVREATAAFGRGECYVERYLD 214 A + LP +K A G GKG T E R+A AA G C +E+ L Sbjct: 165 DAALDAVLPGILKTARLGYDGKGQVRVSTARE--------ARDAHAALGGVPCVLEKRL- 215 Query: 215 KPRHVEAQVI----ADQHGNVVVAGTRDCSLQRRYQKLVE---EAPAPFLTDFQRKEIHD 267 P E + AD Q + + PAP + +E Sbjct: 216 -PLKYEVSALIARGADGRSAAFPLA------QNVHHNGILALTIVPAPAADTARVEEAQQ 268 Query: 268 SAKRICKEAHYHGAGTVEYLVGQDGLISFLEVNTRLQVEHPVTEETAGIDLVLQQFRIAN 327 +A RI Y G VE+ V +DG E+ R T + QQ R Sbjct: 269 AAVRIADTLGYVGVLCVEFFVLEDGSFVANEMAPRPHNSGHYTVDACATSQFEQQVRAMT 328 Query: 328 GEKLDITEDPTPRGHAIEFRIN 349 L PR H+ +N Sbjct: 329 RMPL-----GNPRQHSPAAMLN 345 >2CZG-A nrPDB Length = 433 Score = 65.5 bits (158), Expect = 7e-11, Method: Composition-based stats. Identities = 66/342 (19%), Positives = 124/342 (36%), Gaps = 40/342 (11%) Query: 5 AGSRIARISKVLVANRGEIAVRVIRAARDAGLPSVAVYAEPDAESPHVRLADEAFALGGQ 64 + K+L+ GE+ + A+ G+ VAV + A +P +++A ++ Sbjct: 12 GTATTDSAQKILLLGSGELGKEIAIEAQRLGVEVVAV--DRYANAPAMQVAHRSY----- 64 Query: 65 TSAESYLDFAKILDAAAKSGANAIHPGYGFLAENADFAQAVIDAGLIWIGPSPQSIR-DL 123 + +D + + +AI P + +A F G ++ P+ ++ + Sbjct: 65 --VGNMMDKDFLWSVVEREKPDAIIPEIEAINLDALFE--FEKDGY-FVVPNARATWIAM 119 Query: 124 GDKVTARHIAARAQAPLVPGTPDPVKGADEVVAFAEEYGLPIAIKAAHGGGGKGMKVART 183 + + A+ P DE+ E+ G P KA GKG + Sbjct: 120 HRERLRETLVKEAKVPT--SRYMYATTLDELYEACEKIGYPCHTKAIMSSSGKGSYFVKG 177 Query: 184 IDEIPELYESAVREATAAFGRGECYVERYLDKPRHVEAQVIA----DQHGNVVVAGTR-- 237 ++IP+ +E A +A + + VE ++D VE +A D++G +V + Sbjct: 178 PEDIPKAWEEAKTKARGS--AEKIIVEEHIDF--DVEVTELAVRHFDENGEIVTTFPKPV 233 Query: 238 -DCSLQRRYQKLVEEAPAPFLTDFQRKEIHDSAKRICKEAHYHGAGTVEYLVGQDGLISF 296 + Y + A +++ +E++ AKRI G VE V D + Sbjct: 234 GHYQIDGDYHASWQPAE---ISEKAEREVYRIAKRITDVLGGLGIFGVEMFVKGD-KVWA 289 Query: 297 LEVNTRLQVEHPVTEETA------GIDLVLQQFRIANGEKLD 332 EV+ R H T G R G + Sbjct: 290 NEVSPR---PHD-TGMVTLASHPPGFSEFALHLRAVLGLPIP 327 >3VPD-A nrPDB Length = 281 Score = 65.5 bits (158), Expect = 7e-11, Method: Composition-based stats. Identities = 48/232 (20%), Positives = 88/232 (37%), Gaps = 29/232 (12%) Query: 102 AQAVIDAGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPGTPDPVKGADEVVAFAEEY 161 A+ + G+ + P+ I GDK A+A P P T +E + E + Sbjct: 66 ARYLTALGIPVVN-RPEVIEACGDKWATSVALAKAGLPQ-PKT-ALATDREEALRLMEAF 122 Query: 162 GLPIAIKAAHGGGGKGMKVARTIDEIPELYESAVREATAAFGRGECYVERYLDKP-RHVE 220 G P+ +K G G+ + L E +E F Y++ Y++KP R + Sbjct: 123 GYPVVLKPVIGSWGRLLAKVTDRAAAEALLE--HKEVLGGFQHQLFYIQEYVEKPGRDIR 180 Query: 221 AQVIADQHGNVVVAGTRDCSLQRRYQKLVE------EAPAPFLTDFQRKEIHDSAKRICK 274 V+ ++ + RR + +A LT+ + +A+ + Sbjct: 181 VFVVGERAIAAIY---------RRSAHWITNTARGGQAENCPLTEEIARLSVGAAEAVGG 231 Query: 275 EAHYHGAGTVEYLVGQDGLISFLEVNTRLQVEHPVTEETAGIDLVLQQFRIA 326 G V+ + GL+ EVN ++ ++ V T G+D+ + R A Sbjct: 232 -----GVVAVDLFESERGLL-VNEVNHTMEFKNSV--HTTGVDIPGEILRYA 275 >4IZO-A nrPDB Length = 419 Score = 65.1 bits (157), Expect = 9e-11, Method: Composition-based stats. Identities = 69/315 (21%), Positives = 110/315 (34%), Gaps = 32/315 (10%) Query: 30 AARDAGLPSVAVYAEPDAESPHVRLADEAFALGGQTSAESYLDFAKILDAAAKSGANAIH 89 AA+ G VAV +PD SP +AD+ +Y D A + + A +A+ Sbjct: 53 AAQAMGY-RVAVL-DPDPTSPAGAVADKHL-------RAAYDDEAALAELAQL--CDAVS 101 Query: 90 PGYGFLAENADFAQAVIDAGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPGTP-DPV 148 + EN A A ++ P+ + + D++ + A + P+ P + Sbjct: 102 TEF----ENVPAASLDFLAQSTFVAPAGRCVAIAQDRIAEKRFIAASGVPVAPHVVIESA 157 Query: 149 KGADEVVAFAEEYGLPIAIKAAHGG-GGKGMKVARTIDEIPELYESAVREATAAFGRGEC 207 + LP +K A G GKG T E + Y + G C Sbjct: 158 AQLAALADADLAAVLPGILKTARLGYDGKGQVRVATAQEARDAY--------GSLGGVPC 209 Query: 208 YVERYLDKPRHVEAQVIADQHGNVVVAGTRDCSLQRRYQKLVE---EAPAPFLTDFQRKE 264 +E+ L P E + + N A Q + + PAP +D ++ Sbjct: 210 VLEKRL--PLKYEVSALIARGANGASAV--FPLAQNTHHGGILSLSVVPAPAASDALVRD 265 Query: 265 IHDSAKRICKEAHYHGAGTVEYLVGQDGLISFLEVNTRLQVEHPVTEETAGIDLVLQQFR 324 +A RI Y G VE+ V +DG + E+ R T + QQ R Sbjct: 266 AQQAAARIADSLDYVGVLCVEFFVLEDGSLVANEMAPRPHNSGHYTVDACETSQFEQQVR 325 Query: 325 IANGEKLDITEDPTP 339 L T +P Sbjct: 326 AMTRLPLGSTRQHSP 340 >4DIM-A nrPDB Length = 403 Score = 63.9 bits (154), Expect = 2e-10, Method: Composition-based stats. Identities = 51/297 (17%), Positives = 107/297 (36%), Gaps = 30/297 (10%) Query: 13 SKVLVANRGEIAVRVIRAARDAGLPSVAVYAEPDAESPHVRLADE--AFALGGQTSAESY 70 ++L+ G + + +AA++ G+ ++A P+A P + LADE + E Sbjct: 8 KRLLILGAGRGQLGLYKAAKELGIHTIA-GTMPNAHKPCLNLADEISYMDISNPDEVEQK 66 Query: 71 ---LDFAKILDAAAKSGANAIHPGYGFLAENADFAQAVIDAGLIWIGPSPQSIRDLGDKV 127 L+ +G + A+ L +G + ++ GDK Sbjct: 67 VKDLNLDGAATCCLDTGIVS-------------LARICDKENL--VGLNEEAAIMCGDKY 111 Query: 128 TARHIAARAQAPLVPGTPDPVKGADEVVAFAEEYGLPIAIKAAHGGGGKGMKVARTIDEI 187 + + V+ +E+ E LP+ +KA G KG+ +A+ +E Sbjct: 112 KMKEAFKKYNVNT--ARHFVVRNENELKNALENLKLPVIVKATDLQGSKGIYIAKKEEEA 169 Query: 188 PELYESAVREATAAFGRGECYVERYLDKPRHVEAQVIADQHGNVVVAGTRDCSLQRRYQK 247 + + + R C VE +++ AQ ++ + V D + Sbjct: 170 IDGFNETMNLTK----RDYCIVEEFIEGY-EFGAQAFVYKNDVLFVMPHGDETYMSHTAV 224 Query: 248 LVEEAPAPFLTDFQRKEIHDSAKRICKEAHYHG-AGTVEYLVGQDGLISFLEVNTRL 303 V + D ++ K+ K + A V+ ++ +D + +E+ R+ Sbjct: 225 PVGHYVPLDVKDDIIEKTKTEVKKAIKALGLNNCAVNVDMIL-KDNEVYIIELTGRV 280 >1UC8-A nrPDB Length = 280 Score = 61.2 bits (147), Expect = 1e-09, Method: Composition-based stats. Identities = 45/232 (19%), Positives = 86/232 (37%), Gaps = 29/232 (12%) Query: 102 AQAVIDAGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPGTPDPVKGADEVVAFAEEY 161 A+ + G+ + P+ I GDK A+A P P T +E + E + Sbjct: 66 ARYLTALGIPVVN-RPEVIEACGDKWATSVALAKAGLPQ-PKT-ALATDREEALRLMEAF 122 Query: 162 GLPIAIKAAHGGGGKGMKVARTIDEIPELYESAVREATAAFGRGECYVERYLDKP-RHVE 220 G P+ +K G G+ +A +E F Y++ Y++KP R + Sbjct: 123 GYPVVLKPVIGSWGR--LLAXXXXXXXXXXXXXXKEVLGGFQHQLFYIQEYVEKPGRDIR 180 Query: 221 AQVIADQHGNVVVAGTRDCSLQRRYQKLVE------EAPAPFLTDFQRKEIHDSAKRICK 274 V+ ++ + RR + +A LT+ + + + + Sbjct: 181 VFVVGERAIAAIY---------RRSAHWITNTARGGQAENCPLTEEVARL----SVKAAE 227 Query: 275 EAHYHGAGTVEYLVGQDGLISFLEVNTRLQVEHPVTEETAGIDLVLQQFRIA 326 G V+ + GL+ EVN ++ ++ V T G+D+ + + A Sbjct: 228 AVG-GGVVAVDLFESERGLL-VNEVNHTMEFKNSV--HTTGVDIPGEILKYA 275 >3K5H-A nrPDB Length = 403 Score = 61.2 bits (147), Expect = 1e-09, Method: Composition-based stats. Identities = 40/192 (20%), Positives = 76/192 (39%), Gaps = 11/192 (5%) Query: 113 IGPSPQSIRDLGDKVTARHIAARAQAPLVPGTPDPVKGADEVVAFAEEYGLPIAIKA-AH 171 I PS Q+IR + +K + + P+ E+ E+ G P+ +K+ Sbjct: 111 IEPSWQAIRTIQNKFNQKEHLRKYGIPMAEHRELVENTPAELAKVGEQLGYPLMLKSKTM 170 Query: 172 GGGGKGMKVARTIDEIPELYESAVREATAAFGRGECYVERYLDKPRHVEAQVIADQHGNV 231 G+G + D+IPE E A Y E++ +E VI + + Sbjct: 171 AYDGRGNFRVNSQDDIPEALE--------ALKDRPLYAEKWA--YFKMELAVIVVKTKDE 220 Query: 232 VVAGTRDCSLQRRYQKLVEEAPAPFLTDFQRKEIHDSAKRICKEAHYHGAGTVEYLVGQD 291 V++ ++Q + APA ++D ++ + A++ G VE + +D Sbjct: 221 VLSYPTVETVQEDSICKLVYAPARNVSDAINQKAQELARKAVAAFDGKGVFGVEMFLLED 280 Query: 292 GLISFLEVNTRL 303 I E+ +R+ Sbjct: 281 DSIMLCEIASRI 292 >1EZ1-A nrPDB Length = 392 Score = 60.1 bits (144), Expect = 3e-09, Method: Composition-based stats. Identities = 52/292 (17%), Positives = 99/292 (33%), Gaps = 25/292 (8%) Query: 14 KVLVANRGEIAVRVIRAARDAGLPSVAVYAEPDAESPHVRLADEAFALGGQTSAESYLDF 73 +V++ GE+ V + G+ +AV DA + HV + + ++ Sbjct: 14 RVMLLGSGELGKEVAIECQRLGVEVIAVDRYADAPAMHVAHRSHVINMLDGDALRRVVEL 73 Query: 74 AKILDAAAKSGANAIHPGYGFLAENADFAQAVIDAGLIWIGPSPQSIRDLGDKVTARHIA 133 K + A A D + + GL + + + + + R A Sbjct: 74 EKPHYIVPEIEAIAT-----------DMLIQLEEEGLNVVPCARATKLTMNREGIRRLAA 122 Query: 134 ARAQAPLVPGTPDPVKGADEVVAFAEEYGLPIAIKAAHGGGGKGMKVARTIDEIPELYES 193 Q P T + G P +K GKG R+ +++ + ++ Sbjct: 123 EELQLPT--STYRFADSESLFREAVADIGYPCIVKPVMSSSGKGQTFIRSAEQLAQAWKY 180 Query: 194 AVREATAAFGRGECYVERYLDKPRHVEAQVIADQHGNVVVAGTRDCSL--QRRYQKLVEE 251 A + A G G VE + E ++ + V C+ R+ E Sbjct: 181 AQQGGRA--GAGRVIVEGVVKF--DFEITLLTVSAVDGVH----FCAPVGHRQEDGDYRE 232 Query: 252 APAP-FLTDFQRKEIHDSAKRICKEAHYHGAGTVEYLVGQDGLISFLEVNTR 302 + P ++ + + A+++ +G VE V D +I F EV+ R Sbjct: 233 SWQPQQMSPLALERAQEIARKVVLALGGYGLFGVELFVCGDEVI-FSEVSPR 283 >2PVP-A nrPDB Length = 367 Score = 59.3 bits (142), Expect = 5e-09, Method: Composition-based stats. Identities = 41/252 (16%), Positives = 91/252 (36%), Gaps = 42/252 (16%) Query: 67 AESYLDFAKILDAAAKSGANAIHPGYGFLAENADFAQAVIDAGLIWIGPSPQSIRDLGDK 126 S+L AKI++ N +H G G E+ A + + +IGP ++ +K Sbjct: 97 KNSFL-GAKIIELPLVI--NLVHGGDG---EDGKLASLLEFYRIAFIGPRIEASVLSYNK 150 Query: 127 VTARHIAARAQAPLVPGTPDPVKGADEVVAFA---EEYGLPIAIKAAHGGGGKGMKVART 183 + A + D V ++ A A + P +K ++ G G+ V + Sbjct: 151 YLTKLYAKDLGIKTL----DYVLLNEKNRANALDLMNFNFPFIVKPSNAGSSLGVNVVKE 206 Query: 184 IDEIPELYESAVREATAAFGRGECYVERYLDKPRHVEAQVIADQHGNVVVAGTRDC--SL 241 E+ +SA + E +E ++ + E + + C + Sbjct: 207 EKELIYALDSAFEYSK------EVLIEPFIQGVK--EYNLAGCK------IKKDFCFSYI 252 Query: 242 QRRY--------QKLVEE----APAPFLTDFQRKEIHDSAKRICKEAHYHGAGTVEYLVG 289 + QK ++ AP L++ +++ ++ K++ + ++ V Sbjct: 253 EEPNKQEFLDFKQKYLDFSRNKAPKASLSNALEEQLKENFKKLYSDLFDGAIIRCDFFVI 312 Query: 290 QDGLISFLEVNT 301 ++ + E+N Sbjct: 313 EN-EVYLNEINP 323 >2YS6-A nrPDB Length = 451 Score = 57.8 bits (138), Expect = 2e-08, Method: Composition-based stats. Identities = 57/300 (19%), Positives = 107/300 (35%), Gaps = 37/300 (12%) Query: 71 LDFAKILDAAAKSGANAIHPGYGFLAENADFAQAVIDAGLIWIGPSPQSIRDLGDKVTAR 130 LD ++ A + + G + + GL GPS ++ G K A+ Sbjct: 70 LDIEALVQFAKQQAIDLTIVGPEAPLASG-IVDRFMAEGLRIFGPSQRAALIEGSKAFAK 128 Query: 131 HIAARAQAPLVPGTPDPVKGADEVVAFAEEYGLPIAIKAAHGGGGKGMKVARTIDEIPEL 190 + + P +E A+ E+ G PI IKA GKG+ VA+T++E Sbjct: 129 ELMKKYGIPT--ADHAAFTSYEEAKAYIEQKGAPIVIKADGLAAGKGVTVAQTVEEALAA 186 Query: 191 YESAVREATAAFGRGECYVERYLDKPRHVEAQVIADQHGNVVVAGTRDCSLQRRYQKLVE 250 ++A+ + + +E YL+ E +A +G V ++ + +++ + Sbjct: 187 AKAALVDGQFGTAGSQVVIEEYLEGE---EFSFMAFVNGEKVYP----LAIAQDHKRAYD 239 Query: 251 ------------EAPAPFLTDFQRKEIHDSAKR-ICKEAHYHGAGTVEYLVGQ----DGL 293 +P P ++D ++ R K G + L Sbjct: 240 GDEGPNTGGMGAYSPVPQISDEMMDAALEAILRPAAKALAAEGRPFLGVLYAGLMATANG 299 Query: 294 ISFLEVNTRL-----QVEHPVTEETAGIDLVLQQFRIANGEKLDIT-EDPTPRGHAIEFR 347 +E N R QV P + DLV + +G++L++ D G + + Sbjct: 300 PKVIEFNARFGDPEAQVVLPRLK----TDLVEAVLAVMDGKELELEWTDEAVLGVVLAAK 355 >2XD4-A nrPDB Length = 422 Score = 57.4 bits (137), Expect = 2e-08, Method: Composition-based stats. Identities = 45/220 (20%), Positives = 73/220 (33%), Gaps = 28/220 (12%) Query: 101 FAQAVIDAGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPGTPDPVKGADEVVAFAEE 160 AGL GPS + G K A+ + + P + DE A+ +E Sbjct: 78 LVDEFEKAGLHVFGPSKAAAIIEGSKQFAKDLMKKYDIPT--AEYETFTSFDEAKAYVQE 135 Query: 161 YGLPIAIKAAHGGGGKGMKVARTIDEIPELYESAVREATAAFGRGECYVERYLDKPRHVE 220 G PI IKA GKG+ VA T +E + + +E YL E Sbjct: 136 KGAPIVIKADGLAAGKGVTVAMTEEEAIACLHDFLEDEKFGDASASVVIEEYLSGE---E 192 Query: 221 AQVIADQHGNVVVAGTRDCSLQRRYQKLVE------------EAPAPFLTDFQ-RKEIHD 267 ++A G V + + +++ + +P P +++ R + Sbjct: 193 FSLMAFVKGEKVYPM----VIAQDHKRAFDGDKGPNTGGMGAYSPVPQISEETVRHAVET 248 Query: 268 SAKRICKEAHYHGAGTVEYLV-----GQDGLISFLEVNTR 302 K K G L ++G +E N R Sbjct: 249 IVKPAAKAMVQEGRSFTGVLYAGLMLTENGS-KVIEFNAR 287 >2IP4-A nrPDB Length = 417 Score = 55.4 bits (132), Expect = 7e-08, Method: Composition-based stats. Identities = 59/250 (23%), Positives = 96/250 (38%), Gaps = 40/250 (16%) Query: 101 FAQAVIDAGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPGTPDPVKGADEVVAFAEE 160 A A GL+ GP+ ++ G K A+ + R P + E +A+ EE Sbjct: 77 IADAFQARGLLLFGPTQKAAMIEGSKAFAKGLMERYGIPT--ARYRVFREPLEALAYLEE 134 Query: 161 YGLPIAIKAAHGGGGKGMKVARTIDEIPELYESAVREATAAFGRGECYVERYLDKPRHVE 220 G+P+ +K + GKG+ VA + + + + + A GE VE YL+ E Sbjct: 135 VGVPVVVKDSGLAAGKGVTVAFDLHQAKQAVANILNRAE----GGEVVVEEYLEGE---E 187 Query: 221 AQVIADQHGNVVVAGTRDCSLQRRYQKLVE------------EAPAPFLTDFQR---KEI 265 A V+A G ++ + +++L++ AP P R +EI Sbjct: 188 ATVLALTDGETILP----LLPSQDHKRLLDGDQGPMTGGMGAVAPYPMDEATLRRVEEEI 243 Query: 266 HDSAKRICKEAH--YHGAGTVEYLVGQDGLISFLEVNTRL-----QVEHPVTEETAGIDL 318 R + Y G ++ ++G LE N R Q P+ E DL Sbjct: 244 LGPLVRGLRAEGVVYRGVVYAGLMLTREGP-KVLEFNARFGDPEAQALLPLLEN----DL 298 Query: 319 VLQQFRIANG 328 V R+A G Sbjct: 299 VELALRVAEG 308 >4MAM-A nrPDB Length = 373 Score = 55.4 bits (132), Expect = 8e-08, Method: Composition-based stats. Identities = 44/192 (22%), Positives = 76/192 (39%), Gaps = 17/192 (8%) Query: 115 PSPQSIRDLGDKVTARHIAARAQAPLVPGTPDPVKGADEVVAFAEEYGLPIAIKAAHGG- 173 PS ++I D++ + + ++ + +++GLP +K G Sbjct: 87 PSAKAIAISQDRLLEKSFMQDHGIAT--AKFVNIDSLAKLQSAVDDHGLPAILKTRRFGY 144 Query: 174 GGKGMKVARTIDEIPELYESAVREATAAFGRGECYVERYLDKPRHVEAQVIADQHGNVVV 233 GKG V R+ ++I + ++ G Y E ++D V AD GN+ Sbjct: 145 DGKGQFVIRSQEDITKAWDVLKDA-----PDGLIY-EAFVDFDYEVSQICTADLKGNIA- 197 Query: 234 AGTRDCSLQRRYQK--LVEEAPAPFLTDFQRKEIHDSAKRICKEAHYHGAGTVEYLVGQD 291 L R K ++ E+ APF ++ AK + KE Y G +E+ V D Sbjct: 198 ----FYPLARNTHKQGIIVESEAPFENVVLAEKAQQIAKILVKEFAYVGTLAIEFFVKGD 253 Query: 292 GLISFLEVNTRL 303 LI E+ R+ Sbjct: 254 ELI-VNEIAPRV 264 >2PN1-A nrPDB Length = 331 Score = 55.1 bits (131), Expect = 9e-08, Method: Composition-based stats. Identities = 59/320 (18%), Positives = 106/320 (33%), Gaps = 44/320 (13%) Query: 15 VLVANRGEIAVRVIRAARDAGLPSVAVYAEPDAE--SPHVRLADEAFALGGQTSAESYLD 72 +L+ + G A V ++ V + D + + +AD+ + + E Y Sbjct: 7 LLITSAGRRAKLVEYFVKEFKTGRV---STADCSPLASALYMADQHYIVPKIDEVE-Y-- 60 Query: 73 FAKILDAAAKSGANA----IHPGYGFLAENADFAQAVIDAGLIWIGPSPQSIRDLGDKVT 128 +L G A I P G L A + G+ I + DK T Sbjct: 61 IDHLLTLCQDEGVTALLTLIDPELGLL---AQATERFQAIGVTVIVSPYAACELCFDKYT 117 Query: 129 ARHIAARAQAPLVPGTPDPVKGADEVVAFAEEYGLPIAIKAAHGGGGKGMKVARTIDEIP 188 R T + +E +A A E LP+ +K +G ++ T++E+ Sbjct: 118 MYEYCLRQGIAHA-RTYATMASFEEALA-AGEVQLPVFVKPRNGSASIEVRRVETVEEVE 175 Query: 189 ELYESAVREATAAFGRGECYVERYLDKPRHVEAQVIADQ-HGNVVVAGTRDCSLQRRYQK 247 +L+ + V+ L + + D G V ++ K Sbjct: 176 QLFSK----------NTDLIVQELLVG-QELGVDAYVDLISGKVTSIFIKE--------K 216 Query: 248 LVEEAPAPFLTDFQRKEIHDSAKRICKEA--HYHGAGTVEY-LVGQDGLISFLEVNTRLQ 304 L A TD R + D + + G +++ L G + E+N R Sbjct: 217 LTMRA---GETDKSRSVLRDDVFELVEHVLDGSGLVGPLDFDLFDVAGTLYLSEINPRFG 273 Query: 305 VEHPVTEETAGIDLVLQQFR 324 +P E G++ Q +R Sbjct: 274 GGYPHAYE-CGVNFPAQLYR 292 >2QK4-A nrPDB Length = 452 Score = 54.3 bits (129), Expect = 2e-07, Method: Composition-based stats. Identities = 26/131 (19%), Positives = 48/131 (36%), Gaps = 6/131 (4%) Query: 105 VIDAGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPGTPDPVKGADEVVAFAEEYGLP 164 + AG+ GP+ ++ + K A+ R P +E +F P Sbjct: 108 LRSAGVQCFGPTAEAAQLESSKRFAKEFMDRHGIPTAQWK--AFTKPEEACSFILSADFP 165 Query: 165 -IAIKAAHGGGGKGMKVARTIDEIPELYESAVREATAAFGRGECYVERYLDKPRHVEAQV 223 + +KA+ GKG+ VA++ +E + + ++E +E LD E Sbjct: 166 ALVVKASGLAAGKGVIVAKSKEEACKAVQEIMQEKAFGAAGETIVIEELLDGE---EVSC 222 Query: 224 IADQHGNVVVA 234 + G V Sbjct: 223 LCFTDGKTVAP 233 >5VEV-A nrPDB Length = 431 Score = 54.3 bits (129), Expect = 2e-07, Method: Composition-based stats. Identities = 66/352 (18%), Positives = 121/352 (34%), Gaps = 55/352 (15%) Query: 106 IDAGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPGTPDPVKGADEVVAFAEEYGLPI 165 AGL GP+ + + K A+ + P + AD + + G PI Sbjct: 91 RAAGLKIFGPTQYAAQLESSKDFAKAFMVKYNIPT--AQYQTFENADAAHDYVNQKGAPI 148 Query: 166 AIKAAHGGGGKGMKVARTIDEIPELYESAVREATAAFGRGECYVERYLDKPRHVEAQVIA 225 IKA GKG+ VA T+DE + + +E +L EA I Sbjct: 149 VIKADGLVAGKGVIVAMTLDEAHAAIDDMLLGNKMGNAGERVVIEDFLQGE---EASFIV 205 Query: 226 DQHGNVVVAGTRDCSLQRRYQKLVE------------EAPAPFLTDFQRKE-IHDSAKRI 272 GN V+ + +++L++ +PAP +T + +++ Sbjct: 206 MVDGNHVLPMAT----SQDHKRLLDGDKGPNTGGMGAYSPAPVVTPAVYERAMNEIILPT 261 Query: 273 CKEAHYHGAGTVEYLV-----GQDGLISFLEVNTRL---QVEHPVTEETAGI-DLVLQQF 323 G +L Q G +E N R + + ++ + + DLV Sbjct: 262 VAGMKAEGHEFTGFLYAGLMIDQSGAPYTIEFNCRFGDPETQPIMSRLNSDLADLVEAAI 321 Query: 324 RIANGEKLDITEDPTPR---GHAIEFRINGEDAGRNFLPAP-------GPVTKFHPPSGP 373 +G + + P+ G + + E + + + G V FH + Sbjct: 322 ---DGRLDSVKAEWNPQTAVGVVLAAQNYPETPKKGDVISGLDDVNRIGKV--FHAGTTV 376 Query: 374 GVRVDSGVETGSVIGGQFDSMLAKLIVHGADRAEALARARRALNEFGVEGLA 425 + D G ++ ++ G D A+A A+A AL + +G+ Sbjct: 377 NEKGDVLTNGGRILC---------VVGLGDDVAQAKAKAYGALEKISFDGMQ 419 >1GSO-A nrPDB Length = 431 Score = 53.9 bits (128), Expect = 2e-07, Method: Composition-based stats. Identities = 51/213 (23%), Positives = 76/213 (35%), Gaps = 23/213 (10%) Query: 106 IDAGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPGTPDPVKGADEVVAFAEEYGLPI 165 AGL GP+ + + G K + AR + P + +A+ E G PI Sbjct: 87 RAAGLKIFGPTAGAAQLEGSKAFTKDFLARHKIPTAEYQN--FTEVEPALAYLREKGAPI 144 Query: 166 AIKAAHGGGGKGMKVARTIDEIPELYESAVREATAAFGRG--ECYVERYLDKPRHVEAQV 223 IKA GKG+ VA T++E + A AFG +E +LD EA Sbjct: 145 VIKADGLAAGKGVIVAMTLEEAEAAVHDML--AGNAFGDAGHRIVIEEFLDGE---EASF 199 Query: 224 IADQHGNVVVAGTRDCSLQRRYQK--------LVEEAPAPFLTDF-QRKEIHDSAKRICK 274 I G V+ +R K + +PAP +TD ++ + K Sbjct: 200 IVMVDGEHVLPMATSQDHKRVGDKDTGPNTGGMGAYSPAPVVTDDVHQRTMERIIWPTVK 259 Query: 275 EAHYHGAGTVEYLV-----GQDGLISFLEVNTR 302 G +L + G +E N R Sbjct: 260 GMAAEGNTYTGFLYAGLMIDKQGNPKVIEFNCR 292 >3MJF-A nrPDB Length = 431 Score = 53.9 bits (128), Expect = 2e-07, Method: Composition-based stats. Identities = 52/223 (23%), Positives = 79/223 (35%), Gaps = 37/223 (16%) Query: 103 QAVIDAGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPGTPDPVKGADEVVAFAEEYG 162 A AGL GP+ + + G K + AR P + +A+ + G Sbjct: 85 DAFRAAGLAIFGPTQAAAQLEGSKAFTKDFLARHNIPSAEYQN--FTDVEAALAYVRQKG 142 Query: 163 LPIAIKAAHGGGGKGMKVARTIDEIPELYESAVREATAAFGRG--ECYVERYLDKPRHVE 220 PI IKA GKG+ VA T +E + A AFG VE +LD E Sbjct: 143 APIVIKADGLAAGKGVIVAMTQEEAETAVNDML--AGNAFGDAGHRIVVEEFLDGE---E 197 Query: 221 AQVIADQHGNVVVAGTRDCSLQRRYQKLVE------------EAPAPFLTDFQRKEIHDS 268 A I G V+ + ++++ + +PAP +TD + + D Sbjct: 198 ASFIVMVDGENVLPMAT----SQDHKRVGDGDTGPNTGGMGAYSPAPVVTDDVHQRVMDQ 253 Query: 269 ---------AKRICKEAHYHGAGTVEYLVGQDGLISFLEVNTR 302 A + AG ++ DG +E N R Sbjct: 254 VIWPTVRGMAAEGNIYTGFLYAG---LMISADGQPKVIEFNCR 293 >3WO0-A nrPDB Length = 470 Score = 53.9 bits (128), Expect = 2e-07, Method: Composition-based stats. Identities = 44/233 (18%), Positives = 78/233 (33%), Gaps = 35/233 (15%) Query: 73 FAKILDAAAKSGANAIHPGYGFLAENADF----AQAVIDAGLIWIGPSPQSIRDLGDKVT 128 +I+ A GA+AI N F A+A GL G Q+ + DK Sbjct: 91 VEQIVKVAEMFGADAI------TTNNELFIAPMAKACERLGLR--GAGVQAAENARDKNK 142 Query: 129 ARHIAARAQAPLVPGTPDPVKGADEVVAFAEEYGLPIAIKAAHGGGGKGMKVART----I 184 R +A + V ++ A EE G P+ +K + G+ + Sbjct: 143 MRDAFNKAGVKSIKNKR--VTTLEDFRAALEEIGTPLILKPTYLASSIGVTLITDTETAE 200 Query: 185 DEI--PELYESAVREATAAFGRGECYVERYLDK-----------PRHVEAQ-VIADQHGN 230 DE Y ++ A E +L ++ + ++AD G Sbjct: 201 DEFNRVNDYLKSINVPKAVTFEAPFIAEEFLQGEYGDWYQTEGYSDYISIEGIMAD--GE 258 Query: 231 VVVAGTRDCSLQRRYQKLVEEAPAPFLTDFQRKEIHDSAKRICKEAHYHGAGT 283 D + Q + + P+ L + +K+I ++AK+ + T Sbjct: 259 YFPIAIHDKTPQIGFTETSHITPS-ILDEEAKKKIVEAAKKANEGLGLQNCAT 310 >1VKZ-A nrPDB Length = 412 Score = 50.4 bits (119), Expect = 2e-06, Method: Composition-based stats. Identities = 61/322 (18%), Positives = 112/322 (34%), Gaps = 47/322 (14%) Query: 114 GPSPQSIRDLGDKVTARHIAARAQAPLVPGTPDPVKGADEVVAFAEEYGLPIAIKAAHGG 173 GP + R G KV A+ + + + +E+ +++ P IKA Sbjct: 95 GPVKEVARLEGSKVYAKRFMKKYGIRT--ARFEVAETPEELREKIKKFSPPYVIKADGLA 152 Query: 174 GGKGMKVARTIDE-IPELYESAVREATAAFGRGECYVERYLDKPRHVEAQVIADQHGNVV 232 GKG+ + + +E I + + + E +G ++ +L + A + + V+ Sbjct: 153 RGKGVLILDSKEETIEKGSKLIIGELIKGV-KGPVVIDEFLAG-NELSAMAVVNGRNFVI 210 Query: 233 VAGTRDCSLQRRYQKLV--EEAPA------------PFLTDFQRKEIHDSAKRICKEAHY 278 + RD Y++L+ + P P T + +E+ D ++ Y Sbjct: 211 LPFVRD------YKRLMDGDRGPNTGGMGSWGPVEIPSDTIKKIEELFDKTLWGVEKEGY 264 Query: 279 HGAGTVEY-LVGQDGLISFLEVNTRLQVEHPVTEETAGIDLVLQQFRIANGEKLDITEDP 337 G + L+ DG LE N RL P TE ++ + G + E Sbjct: 265 AYRGFLYLGLMLHDGDPYILEYNVRLG--DPETEVIVTLNPEGFVNAVLEGYRGGKMEPV 322 Query: 338 TPRGHAI----EFRINGEDAGRN---FLPAPGPVTKFHPPSGPGVRVDSGVETGSVIGGQ 390 PRG A+ R + + LP G + +G + V G + Sbjct: 323 EPRGFAVDVVLAARGYPDAPEKGKEITLPEEGLI----FFAGVAEKDGKLVTNGGRV--- 375 Query: 391 FDSMLAKLIVHGADRAEALARA 412 + G + EA +A Sbjct: 376 -----LHCMGTGETKEEARRKA 392 >2Z04-A nrPDB Length = 365 Score = 48.1 bits (113), Expect = 1e-05, Method: Composition-based stats. Identities = 35/202 (17%), Positives = 80/202 (39%), Gaps = 18/202 (8%) Query: 103 QAVIDAGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPGTPDPVKGADEVVAFAEEYG 162 + + I P+PQ++ ++ + + P VP V DE++ + + Sbjct: 71 EVLEKCESKLI-PNPQALYVKKSRIREKLFLKKHGFP-VPEF--LVIKRDEIIDALKSFK 126 Query: 163 LPIAIKAAHGG-GGKGMKVARTIDEIPELYESAVREATAAFGRGECYVERYLDKPRHVEA 221 LP+ IKA G GKG + +++ ++ ++ +E +E ++ + Sbjct: 127 LPVVIKAEKLGYDGKGQYRIKKLEDANQVVKNHDKE-------ESFIIEEFVKFEAEISC 179 Query: 222 QVIADQHGNVVVAGTRDCSLQRRYQKLVEEAPAPFLTDFQRKEIHDSAKRICKEAHYHGA 281 + D+ G ++++ + ++ + KE + KR+ + G Sbjct: 180 IGVRDREGKTYFYPQPF----NKHEEGILI--YNYVPYAKLKEAEEITKRLMELLDIVGV 233 Query: 282 GTVEYLVGQDGLISFLEVNTRL 303 TVE+ + +DG + E R+ Sbjct: 234 FTVEFFLLKDGRVLINEFAPRV 255 >3LP8-A nrPDB Length = 442 Score = 47.7 bits (112), Expect = 2e-05, Method: Composition-based stats. Identities = 24/139 (17%), Positives = 52/139 (37%), Gaps = 3/139 (2%) Query: 101 FAQAVIDAGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPGTPDPVKGADEVVAFAEE 160 + A+ + G++ GPS + R K + + R P + F ++ Sbjct: 99 LSDALTEEGILVFGPSKAAARLESSKGFTKELCMRYGIPT--AKYGYFVDTNSAYKFIDK 156 Query: 161 YGLPIAIKAAHGGGGKGMKVARTIDEIPELYESAVREATAAFGRGECYVERYLDKPRHVE 220 + LP+ +KA GKG + T +E ++ + +E +L+ + + Sbjct: 157 HKLPLVVKADGLAQGKGTVICHTHEEAYNAVDAMLVHHKFGEAGCAIIIEEFLEG-KEIS 215 Query: 221 AQVIADQHGNVVVAGTRDC 239 + D V++ +D Sbjct: 216 FFTLVDGSNPVILGVAQDY 234 >1IYU-A nrPDB Length = 79 Score = 47.0 bits (110), Expect = 2e-05, Method: Composition-based stats. Identities = 16/61 (26%), Positives = 32/61 (52%) Query: 540 GTVVKFAVEEGQEVVAGDLVVVLEAMKMENPVTAHKDGTITGLAVEAGAAITQGTVLAEI 599 G V++ V+ G + +VVLE+ K V + K G + ++V+ G + +G + E+ Sbjct: 13 GEVIELLVKTGDLIEVEQGLVVLESAKASMEVPSPKAGVVKSVSVKLGDKLKEGDAIIEL 72 Query: 600 K 600 + Sbjct: 73 E 73 >4WD3-A nrPDB Length = 413 Score = 44.3 bits (103), Expect = 1e-04, Method: Composition-based stats. Identities = 23/165 (13%), Positives = 56/165 (33%), Gaps = 8/165 (4%) Query: 50 PHVRLADEAFALGGQTSAESYLDFAKILDAAAKSGANAIHPGYGFLAENADFAQAVIDAG 109 + AD + + + + + +L+ + I E + + + Sbjct: 41 LYSHWADHVYIV--DDVTDLTVMKSLMLEILKVGPIDHIVS----TTEKSILTGGFLRSY 94 Query: 110 LIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPGTPDPVKGADEVVAFAEEYGLPIAIKA 169 GP ++ + +K+ + P+ V +++ A E+ G PI +K Sbjct: 95 FGIAGPGFETALYMTNKLAMKTKLKMEGIPVADFL--CVSQVEDIPAAGEKLGWPIIVKP 152 Query: 170 AHGGGGKGMKVARTIDEIPELYESAVREATAAFGRGECYVERYLD 214 A G G + ++D +LY ++ E+ ++ Sbjct: 153 ALGSGALNTFIIHSLDHYEDLYSTSGGLGELKKNNSLMIAEKCIE 197 >1ZY8-K nrPDB Length = 229 Score = 42.7 bits (99), Expect = 5e-04, Method: Composition-based stats. Identities = 17/49 (34%), Positives = 27/49 (55%) Query: 540 GTVVKFAVEEGQEVVAGDLVVVLEAMKMENPVTAHKDGTITGLAVEAGA 588 G +VK+ +EG+ V AGD + +E K + A DG + + VE G+ Sbjct: 18 GNIVKWLKKEGEAVSAGDALCEIETDKAVVTLDASDDGILAKIVVEEGS 66 >2R84-A nrPDB Length = 334 Score = 42.7 bits (99), Expect = 5e-04, Method: Composition-based stats. Identities = 27/166 (16%), Positives = 64/166 (38%), Gaps = 29/166 (17%) Query: 24 AVRVIRAARDAGLPSVAVYAEPDAESP--HVRLADEAFALGGQTSAESYLDFAKILDAAA 81 A+++++ A+D G ++A + + +AD + + + E L+ ++ Sbjct: 13 ALQILKGAKDEGFETIAFGSSKVKPLYTKYFPVAD--YFIEEKYPEEELLNLNAVV---V 67 Query: 82 KSGANAIHPGYGFLAENADFAQAVIDAGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLV 141 +G+ H G + V + + + G + + +R D+ R +A V Sbjct: 68 PTGSFVAHLG----------IELVENMKVPYFG-NKRVLRWESDRNLERKWLKKAGI-RV 115 Query: 142 PGTPDPVKGADEVVAFAEEYGLPIAIKAAHGGGGKGMKVARTIDEI 187 P + ++ P+ +K GGKG +A+ ++ Sbjct: 116 PEVYEDPDDIEK----------PVIVKPHGAKGGKGYFLAKDPEDF 151 >3DUF-I nrPDB Length = 428 Score = 42.3 bits (98), Expect = 5e-04, Method: Composition-based stats. Identities = 15/61 (24%), Positives = 27/61 (44%) Query: 540 GTVVKFAVEEGQEVVAGDLVVVLEAMKMENPVTAHKDGTITGLAVEAGAAITQGTVLAEI 599 G +VK+ V+ G EV D++ ++ K + + G + + V G T G L + Sbjct: 17 GEIVKWFVKPGDEVNEDDVLCEVQNDKAVVEIPSPVKGKVLEILVPEGTVATVGQTLITL 76 Query: 600 K 600 Sbjct: 77 D 77 >2K7V-A nrPDB Length = 85 Score = 40.8 bits (94), Expect = 0.002, Method: Composition-based stats. Identities = 16/69 (23%), Positives = 28/69 (40%) Query: 532 DAVTAPMQGTVVKFAVEEGQEVVAGDLVVVLEAMKMENPVTAHKDGTITGLAVEAGAAIT 591 V P V + V+ G +V A ++ +E K V A G + L V G + Sbjct: 3 KEVNVPDIVEVTEVMVKVGDKVAAEQSLITVEGDKASMEVPAPFAGVVKELKVNVGDKVK 62 Query: 592 QGTVLAEIK 600 G+++ + Sbjct: 63 TGSLIMIFE 71 >1QJO-A nrPDB Length = 80 Score = 39.7 bits (91), Expect = 0.004, Method: Composition-based stats. Identities = 14/59 (23%), Positives = 26/59 (44%) Query: 542 VVKFAVEEGQEVVAGDLVVVLEAMKMENPVTAHKDGTITGLAVEAGAAITQGTVLAEIK 600 V + V+ G +V A ++ +E K V A G + L V G + G+++ + Sbjct: 17 VTEVMVKVGDKVAAEQSLITVEGDKASMEVPAPFAGVVKELKVNVGDKVKTGSLIMIFE 75 >3UFX-B nrPDB Length = 397 Score = 37.7 bits (86), Expect = 0.014, Method: Composition-based stats. Identities = 18/50 (36%), Positives = 24/50 (48%), Gaps = 2/50 (4%) Query: 128 TARHIAARAQAPLVPGTPDPVKGADEVVAFAEEYGLPIAIKAAHGGGGKG 177 A+ I AR P+ PG +E AEE+G + IKA GG+G Sbjct: 7 QAKEILARYGVPVPPGKVAYTP--EEAKRIAEEFGKRVVIKAQVHVGGRG 54 >3WVR-A nrPDB Length = 447 Score = 37.7 bits (86), Expect = 0.014, Method: Composition-based stats. Identities = 37/162 (22%), Positives = 57/162 (35%), Gaps = 26/162 (16%) Query: 162 GLPIAIKAAHGGGG--------------KGMKVAR--TIDEIPELYESAVREATAAFGRG 205 G P+ +K +G G +G + R + Y + GR Sbjct: 179 GSPVILKQDYGSGSDGNEILSRTPGLALRGARALRVLADSAALDAYLDERWDWLTEGGRH 238 Query: 206 ECYVERYLDKPRHVEAQVIADQHGNVVVAGTRDCSLQRRYQKL--VEEAPAPFLTDFQRK 263 VERY R A+ G V G + RY+ L + PAP L Q Sbjct: 239 RVVVERYHPGSRAYFAEFWISDGG--VRLGGHG---EMRYRPLPDSQVMPAPDLDQAQLD 293 Query: 264 EIHDSAKRICKEA---HYHGAGTVEYLVGQDGLISFLEVNTR 302 ++ + +R+C Y G + + +V G + F E N R Sbjct: 294 DLVEGGRRLCVALHALGYRGVLSADAVVTPAGEVLFTEHNGR 335 >6CT0-0 nrPDB Length = 647 Score = 35.4 bits (80), Expect = 0.066, Method: Composition-based stats. Identities = 15/58 (25%), Positives = 27/58 (46%), Gaps = 1/58 (1%) Query: 540 GTVVKFAVEEGQEVVAGDLVVVLEAMKMENPVTAHKDGTITGLAVEAGAAITQ-GTVL 596 GTV ++ + G+++ GDL+ +E K ++G + + V G GT L Sbjct: 233 GTVQRWEKKVGEKLSEGDLLAEIETDKATIGFEVQEEGYLAKILVPEGTRDVPLGTPL 290 Score = 31.6 bits (70), Expect = 1.1, Method: Composition-based stats. Identities = 11/49 (22%), Positives = 24/49 (48%) Query: 540 GTVVKFAVEEGQEVVAGDLVVVLEAMKMENPVTAHKDGTITGLAVEAGA 588 GT+ ++ +EG ++ GDL+ +E K + ++ + + V G Sbjct: 106 GTIARWEKKEGDKINEGDLIAEVETDKATVGFESLEECYMAKILVAEGT 154 Score = 30.0 bits (66), Expect = 3.3, Method: Composition-based stats. Identities = 17/103 (16%), Positives = 34/103 (33%), Gaps = 11/103 (10%) Query: 506 CDPVGVIRRKPKPRKR--------GAHTGAAASGDAVTAPMQGTVVKFAVEEGQEVVAGD 557 P R P P +R G + + P +++ G+ + Sbjct: 30 GTPRVTSRSGPAPARRNSVTTGYGGVRALCGWTPSSGATPRNRLLLQLLGSPGRRYYSLP 89 Query: 558 LVVVLEAMKMENPVTAHKDGTITGLAVEAGAAITQGTVLAEIK 600 + + + A GTI + G I +G ++AE++ Sbjct: 90 PHQKVPLPSLSPTMQA---GTIARWEKKEGDKINEGDLIAEVE 129 >1WR2-A nrPDB Length = 238 Score = 34.3 bits (77), Expect = 0.15, Method: Composition-based stats. Identities = 12/41 (29%), Positives = 19/41 (46%), Gaps = 2/41 (4%) Query: 128 TARHIAARAQAPLVPGTPDPVKGADEVVAFAEEYGLPIAIK 168 A+ + P VP K DE + +A+E G P+ +K Sbjct: 24 EAKQVLKAYGLP-VP-EEKLAKTLDEALEYAKEIGYPVVLK 62 >4XZ3-B nrPDB Length = 230 Score = 33.5 bits (75), Expect = 0.25, Method: Composition-based stats. Identities = 20/110 (18%), Positives = 39/110 (35%), Gaps = 11/110 (10%) Query: 128 TARHIAARAQAPLVPGTPDPVKGADEVVAFAEEYGLPIAIK-----AAHGGGGKGMKV-A 181 A++ + P+ K +E V F+ E G P+ +K H G+KV Sbjct: 22 EAKYFISSYGIPVT--NIRLAKSEEEAVNFSREIGFPVVLKIVSPQVVHKSDVGGVKVNL 79 Query: 182 RTIDEIPELYESAVREATAAFGRGE---CYVERYLDKPRHVEAQVIADQH 228 R+ +E+ + Y + E V+ + + ++ D Sbjct: 80 RSEEEVRKAYREIIENVKRNVPNAEIEGILVQEFAPPGVELIIGLLRDPQ 129 >3ZQ4-A nrPDB Length = 555 Score = 33.5 bits (75), Expect = 0.28, Method: Composition-based stats. Identities = 48/328 (14%), Positives = 96/328 (29%), Gaps = 43/328 (13%) Query: 44 EPDAESPHVRLADEAFAL--GGQTSAESYLDFAKILD-----AAAKSGANAIHPGYGFLA 96 E + V+ DE + G + + L ++ + + +G Sbjct: 19 EIGKNTYAVQFQDEIVLIDAGIKFPEDELLGIDYVIPDYTYLVKNEDKIKGLFITHGHED 78 Query: 97 ENADFAQAVIDAGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPGTPDPVKGADEVVA 156 + + G +I L +K+ + + + ++ G D VK V+ Sbjct: 79 HIGGIPYLLRQVNIPVYG-GKLAIGLLRNKLEEHGLLRQTKLNII-GEDDIVKFRKTAVS 136 Query: 157 FAEEY-----GLPIAIKAAHGGGGKGMKVARTID---EIPELYESAVREATAAFGRGECY 208 F I +K G + T D + + E A A G+ Sbjct: 137 FFRTTHSIPDSYGIVVKTPPGN------IVHTGDFKFDFTPVGEPANLTKMAEIGKEGVL 190 Query: 209 -VERYLDKPRHVEAQVIADQHGNVVV----------AGTRDCSLQRRYQKLVEEAPAPFL 257 + + E + + G + S R Q+++E A Sbjct: 191 CLLSDSTNSENPEFTMSERRVGESIHDIFRKVDGRIIFATFASNIHRLQQVIEAAVQNGR 250 Query: 258 TDFQRKEIHDSAKRICKEAHYHGAGTVEYLVGQDGLISFLEVN------TRLQVEHPVTE 311 +SA I + Y ++ + I+ + N T Q E P+ Sbjct: 251 KVAVFGRSMESAIEIGQTLGYINCPKNTFI--EHNEINRMPANKVTILCTGSQGE-PMAA 307 Query: 312 ETAGIDLVLQQFRIANGEKLDITEDPTP 339 + + +Q I G+ + + P P Sbjct: 308 LSRIANGTHRQISINPGDTVVFSSSPIP 335 >1SVC-P nrPDB Length = 365 Score = 32.3 bits (72), Expect = 0.54, Method: Composition-based stats. Identities = 36/217 (16%), Positives = 59/217 (27%), Gaps = 32/217 (14%) Query: 319 VLQQFRIANGEKLDITEDPTPRGHAIEFRINGEDAGRNFLPAPG-----------PVTKF 367 A+G L I E P RG FR E LP + + Sbjct: 32 PQMALPTADGPYLQILEQPKQRGF--RFRYVAEGPSHGGLPGASSEKNKKSYPQVKICNY 89 Query: 368 HPPSGPGVRVDSGVETGSVIGGQFDSMLAKLIVHGA-DRAEALARARRALNEFGVEGL-- 424 P+ V++ V G I S++ K G G+ + Sbjct: 90 VGPAKVIVQL---VTNGKNIHLHAHSLVGKHCEDGICTVTAGPKDMVVGFANLGILHVTK 146 Query: 425 ATVIPFHRAVVSDPAFIGDANGFSVHTRWIETEWNNTIEPFTDGEPLDEDA---RPRQKV 481 V A +++ G G VH + E + R ++ + Sbjct: 147 KKVFETLEARMTEACIRGYNPGLLVHPDL----------AYLQAEGGGDRQLGDREKELI 196 Query: 482 VVEIDGRRVEVSLPADLALSNGGGCDPVGVIRRKPKP 518 + E+ L + D G R+ +P Sbjct: 197 RQAALQQTKEMDLSVVRLMFTAFLPDSTGSFTRRLEP 233 >4NAR-A nrPDB Length = 435 Score = 32.3 bits (72), Expect = 0.56, Method: Composition-based stats. Identities = 25/113 (22%), Positives = 44/113 (38%), Gaps = 10/113 (8%) Query: 187 IPELYESAVREATAAFGRGECYVERYLDKPRHVEAQVIADQHGNVVVAGTRDCSLQR--- 243 I E YE +R A +Y+D+P QVI +++ V AG LQR Sbjct: 238 IDEGYEGFLRAYEKACELSSQLHVKYIDRPLRRAVQVIGEEYDEVWTAGKGSYKLQRPGV 297 Query: 244 --RYQKLVEEAPAPFLTDFQRKEIHDSAKRICKEAHYHGAGTVEYLVGQDGLI 294 + +++ AP +R + + +E YH V++ + + Sbjct: 298 MAKGGQIIIYAPHI-----KRFHSNPQMDKWIREIGYHCKDYVKWYLKKHPDF 345 >4DK0-A nrPDB Length = 369 Score = 31.2 bits (69), Expect = 1.2, Method: Composition-based stats. Identities = 13/43 (30%), Positives = 22/43 (51%) Query: 534 VTAPMQGTVVKFAVEEGQEVVAGDLVVVLEAMKMENPVTAHKD 576 V A + G + K V+ GQ+V GDL+ +++ N + K Sbjct: 35 VGAQVSGKITKLYVKLGQQVKKGDLLAEIDSTTQINTLNTRKA 77 >4HGN-A nrPDB Length = 176 Score = 31.2 bits (69), Expect = 1.3, Method: Composition-based stats. Identities = 17/70 (24%), Positives = 21/70 (30%), Gaps = 11/70 (15%) Query: 114 GPSPQSIRDLGDKVTARHIAARAQAPLVPGTPDPVKGADEVVAFAEEYGLPIAIKAAHGG 173 G S I +GD V + P P EV + A+ A GG Sbjct: 102 GLSDDEILYMGDDVPDIEVMRECGLPCCPK-----DAVPEVKSVAKYISY------ADGG 150 Query: 174 GGKGMKVART 183 G G V Sbjct: 151 RGCGRDVVEQ 160 >3MXU-A nrPDB Length = 143 Score = 31.2 bits (69), Expect = 1.3, Method: Composition-based stats. Identities = 10/42 (23%), Positives = 20/42 (47%) Query: 548 EEGQEVVAGDLVVVLEAMKMENPVTAHKDGTITGLAVEAGAA 589 + G ++ GD V+E++K + V A DG + + + Sbjct: 63 QNGTKLSKGDAAAVVESVKAASDVYAPLDGEVVEINAALAES 104 >3HHS-B nrPDB Length = 684 Score = 31.2 bits (69), Expect = 1.4, Method: Composition-based stats. Identities = 19/138 (13%), Positives = 40/138 (28%), Gaps = 23/138 (16%) Query: 327 NGEKLDITEDPTPRGHAIEFRINGEDAGRNFLPAPGPVTKFHPPSGPGVRVDSGVETGSV 386 GE + +E NG + F P+ + + P ++DS V + + Sbjct: 230 RGELFYYMHQQIIGRYNVERMCNGLPQVKPFSDFSAPIEEGYFP-----KLDSQVASRTW 284 Query: 387 IGGQFDSMLA--------------KLIVHGADRAEALARARRAL---NEFGVEGLATVIP 429 S+ KL EA+ + + E ++ + T I Sbjct: 285 PPRFAGSVFRNLDRTVDQVKIDVRKLFTWRDQFLEAIQKMAIKMPNGRELPLDEV-TGID 343 Query: 430 FHRAVVSDPAFIGDANGF 447 ++ + + Sbjct: 344 MLGNLMESSIISPNRGYY 361 >1ONL-A nrPDB Length = 128 Score = 31.2 bits (69), Expect = 1.4, Method: Composition-based stats. Identities = 11/36 (30%), Positives = 19/36 (52%) Query: 548 EEGQEVVAGDLVVVLEAMKMENPVTAHKDGTITGLA 583 E G+ V G+ V V+E++K + + A G I + Sbjct: 45 EVGRVVEKGEAVAVVESVKTASDIYAPVAGEIVEVN 80 >4JE5-A nrPDB Length = 503 Score = 31.2 bits (69), Expect = 1.5, Method: Composition-based stats. Identities = 10/31 (32%), Positives = 18/31 (58%) Query: 274 KEAHYHGAGTVEYLVGQDGLISFLEVNTRLQ 304 KEA Y A ++L+ +D FL++N ++ Sbjct: 234 KEAIYKIAQKYDFLIVEDEPYYFLQMNPYIK 264 >2CV2-A nrPDB Length = 468 Score = 30.8 bits (68), Expect = 1.6, Method: Composition-based stats. Identities = 21/120 (17%), Positives = 45/120 (37%), Gaps = 14/120 (11%) Query: 175 GKGMKVARTIDEIPELYESAVREATAAFGRGECYVERYLD--KPRHVEAQVIADQHGNVV 232 GK ++ +++E+ E + +REA ++ E Y+ R ++ +PR + + Sbjct: 315 GKYIREVLSLEEVAERVKPFLREAGLSW-ESEAYLRRAVELMRPR---FDTLKEFPEKAR 370 Query: 233 VAGTRDCSLQRRYQKLVEEA--------PAPFLTDFQRKEIHDSAKRICKEAHYHGAGTV 284 T D + + Q+ +EE P + + ++ R G V Sbjct: 371 YLFTEDYPVSEKAQRKLEEGLPLLKELYPRLRAQEEWTEAALEALLRGFAAEKGVKLGQV 430 >3K9D-A nrPDB Length = 464 Score = 30.8 bits (68), Expect = 1.8, Method: Composition-based stats. Identities = 40/245 (16%), Positives = 76/245 (31%), Gaps = 61/245 (24%) Query: 115 PSPQSIRDLGDKVTA-RHIAARAQ----------APLVPGTPDPVKGADEVVAFAEEYGL 163 P P +++ + + V A +A P + GT +K D V A G Sbjct: 143 PHPNALKAILETVRIISEAAEKAGCPKGAISCMTVPTIQGTDQLMKHKDTAVILAT--GG 200 Query: 164 PIAIKAAHGGGGKGMKVARTIDEIPELYESAVREATAAFGRGECYVERYLDKPRHVEAQV 223 +KAA Y S G G ++ER + PR V+ + Sbjct: 201 SAMVKAA--------------------YSSGTPAIGVGPGNGPAFIERSANIPRAVKHIL 240 Query: 224 IADQHGNVVVAGTRDCSLQRRYQKLVEEAPAPFLTDFQRKEIHDSAKRICKEAHYHGAGT 283 + N C+ + Q +V E + ++ + Sbjct: 241 DSKTFDN-----GTICASE---QSVVVERVNKEAVIAEFRKQGAHFLSDAEAVQLG---- 288 Query: 284 VEYLVGQDGLISFLEVNTRL---QVEHPVTEETAGIDLVL-QQFRIAN----GEKLDITE 335 ++++ +G +N + V+H AG+ + + IA G K+ + Sbjct: 289 -KFILRPNGS-----MNPAIVGKSVQHIAN--LAGLTVPADARVLIAEETKVGAKIPYSR 340 Query: 336 DPTPR 340 + Sbjct: 341 EKLAP 345 >1ZP9-A nrPDB Length = 258 Score = 30.8 bits (68), Expect = 1.9, Method: Composition-based stats. Identities = 17/73 (23%), Positives = 33/73 (45%), Gaps = 11/73 (15%) Query: 250 EEAPAPFLTDFQRKE-----------IHDSAKRICKEAHYHGAGTVEYLVGQDGLISFLE 298 +E PAP L + R+ + ++ KR+ +EA A EY + + F++ Sbjct: 153 DELPAPTLVELGRELKELDVEGIFNDVVENVKRLYQEAELVHADLSEYNIMYIDKVYFID 212 Query: 299 VNTRLQVEHPVTE 311 + + + HP+ E Sbjct: 213 MGQAVTLRHPMAE 225 >3TZU-A nrPDB Length = 137 Score = 30.4 bits (67), Expect = 2.1, Method: Composition-based stats. Identities = 15/64 (23%), Positives = 23/64 (35%), Gaps = 8/64 (12%) Query: 523 AHTGAAASGDAVTAPMQGTVVKFAVEEGQEVVAGDLVVVLEAMKMENPVTAHKDGTITGL 582 A GD V + E G+ V AG+ +E+ K + + A G I + Sbjct: 41 TSVAVEALGDLVFVQLP--------EVGETVSAGESCGEVESTKTVSDLIAPASGQIVEV 92 Query: 583 AVEA 586 A Sbjct: 93 NTAA 96 >2KA7-A nrPDB Length = 124 Score = 30.4 bits (67), Expect = 2.5, Method: Composition-based stats. Identities = 15/47 (31%), Positives = 24/47 (51%), Gaps = 1/47 (2%) Query: 540 GTVVKFAV-EEGQEVVAGDLVVVLEAMKMENPVTAHKDGTITGLAVE 585 G VV + E G+EV G++V +E++K V A G I + + Sbjct: 33 GDVVYVDLPEVGREVKKGEVVASIESVKAAADVYAPLSGKIVEVNEK 79 >3A8J-E nrPDB Length = 129 Score = 30.0 bits (66), Expect = 2.7, Method: Composition-based stats. Identities = 12/36 (33%), Positives = 17/36 (47%) Query: 548 EEGQEVVAGDLVVVLEAMKMENPVTAHKDGTITGLA 583 E G V AGD V E++K + + A G I + Sbjct: 47 EVGATVSAGDDCAVAESVKAASDIYAPVSGEIVAVN 82 >4XFJ-A nrPDB Length = 408 Score = 30.0 bits (66), Expect = 3.2, Method: Composition-based stats. Identities = 31/134 (23%), Positives = 49/134 (36%), Gaps = 26/134 (19%) Query: 395 LAKLIVHGADRAEALARARRALNEFGVEGLATVIPFHRAVVSDPAFIGDAN--GFSVHTR 452 LA + + R +A+ A E IP V F D N G +V T Sbjct: 150 LAPVRDYAWTREKAI-----AFAE------ENNIP--INVTKRSPFSIDQNVWGRAVETG 196 Query: 453 WIETEWNN-TIEPFTDGE-PLDEDARPRQKVV-------VEIDGRRVE--VSLPADLALS 501 ++E WN T + ++ E P + P + +V V IDGR V ++ Sbjct: 197 FLEHLWNAPTKDVYSYTEDPTVNWSTPDEVIVGFEQGVPVSIDGRSVTPLQAIEELNRRG 256 Query: 502 NGGGCDPVGVIRRK 515 G + V+ + Sbjct: 257 GEQGVGRLDVVEDR 270 >5N6U-A nrPDB Length = 836 Score = 29.6 bits (65), Expect = 3.5, Method: Composition-based stats. Identities = 21/119 (17%), Positives = 46/119 (38%), Gaps = 13/119 (10%) Query: 2 ASHAGSRIARISKVLVANRGEIAVRVIRAARDAGLPSVAVYAEPDAESPHVRLADEAFAL 61 + + + VL+ +GE+ +V G+ V ++ + D + + Sbjct: 285 RGYGEQNLYTLQLVLLDEKGEVLDKVE---ERFGIRKVELFTQEDNKGESFVFKINNIPV 341 Query: 62 GGQT----SAESYL------DFAKILDAAAKSGANAIHPGYGFLAENADFAQAVIDAGL 110 + A+S+L D+ +L A ++G N + G + EN F + + G+ Sbjct: 342 FAKGANWIPADSFLPRIKEEDYRLLLIRAKEAGVNMLRVWGGGIYENDIFYELCDELGI 400 >3LNN-A nrPDB Length = 359 Score = 29.3 bits (64), Expect = 5.7, Method: Composition-based stats. Identities = 16/78 (20%), Positives = 28/78 (35%), Gaps = 6/78 (7%) Query: 490 VEVSLPADLALSNGGGCDPVGVIRRKPKPRKRGAHTGAAASGDA---VTAPMQGTVVKFA 546 + +PA+ L P R+ A V P+ G +V Sbjct: 16 ERLVVPAESPLRRTLAVAP---ATRETVAAPFNLPAMIEADPAKLVKVLPPLAGRIVSLN 72 Query: 547 VEEGQEVVAGDLVVVLEA 564 + G EV AGD++ +++ Sbjct: 73 KQLGDEVKAGDVLFTIDS 90 >4WKG-A nrPDB Length = 660 Score = 28.9 bits (63), Expect = 6.7, Method: Composition-based stats. Identities = 10/39 (25%), Positives = 16/39 (41%) Query: 417 NEFGVEGLATVIPFHRAVVSDPAFIGDANGFSVHTRWIE 455 + + V GL ++ P F S+H+ WIE Sbjct: 339 DHYEVYGLDIGSDAISRFLNHPHFHFVEGDISIHSEWIE 377 >4OEL-A nrPDB Length = 370 Score = 28.9 bits (63), Expect = 7.0, Method: Composition-based stats. Identities = 10/38 (26%), Positives = 13/38 (34%), Gaps = 1/38 (2%) Query: 500 LSNGGGCDPVGVIRRKPKPRKRGAHTGAAASGDAVTAP 537 L+ G G RK PR + A A + P Sbjct: 172 LTLGDMIRRSGGHSRK-IPRPKPAPLTAEIQQKILHLP 208 >2PZ0-A nrPDB Length = 252 Score = 28.5 bits (62), Expect = 8.6, Method: Composition-based stats. Identities = 13/66 (19%), Positives = 23/66 (34%), Gaps = 16/66 (24%) Query: 383 TGSVIGGQFDSML-----------AKLIVHGADRAEALARARRALNEFGVEGLATVIP-F 430 + + +++ KL DR E + R +A GV+G+ T P Sbjct: 188 EAYSLHPFYFNIIPELVEGCKKNGVKLFPWTVDRKEDMERMIKA----GVDGIITDDPET 243 Query: 431 HRAVVS 436 +V Sbjct: 244 LINLVR 249 >3ZUK-A nrPDB Length = 699 Score = 28.5 bits (62), Expect = 8.9, Method: Composition-based stats. Identities = 14/44 (31%), Positives = 21/44 (47%), Gaps = 1/44 (2%) Query: 461 TIEPFTDGEPLDEDARPRQKVVVEIDGRRV-EVSLPADLALSNG 503 I D +D DARP+ + ++GR + E +PAD A Sbjct: 40 AIPSGIDLSHIDADARPQDDLFGHVNGRWLAEHEIPADRATDGA 83 >3FWW-A nrPDB Length = 456 Score = 28.5 bits (62), Expect = 9.4, Method: Composition-based stats. Identities = 16/60 (26%), Positives = 22/60 (36%), Gaps = 6/60 (10%) Query: 38 SVAVYAEPDAESPHVRLADEAFALGGQTSAESYLDFAKILDAAAKSGANAIHPGYGFLAE 97 SV + A + L L G+ ++DAA K GA +H YG E Sbjct: 7 SVVILAAGKGTRMYSDLPKVLHPLAGKPM------VQHVIDAAMKLGAQHVHLVYGHGGE 60 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.309 0.135 0.352 Lambda K H 0.267 0.0416 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 22,717,951 Number of Sequences: 36641 Number of extensions: 945931 Number of successful extensions: 3180 Number of sequences better than 10.0: 103 Number of HSP's better than 10.0 without gapping: 109 Number of HSP's successfully gapped in prelim test: 55 Number of HSP's that attempted gapping in prelim test: 2876 Number of HSP's gapped (non-prelim): 192 length of query: 600 length of database: 10,336,785 effective HSP length: 103 effective length of query: 497 effective length of database: 6,562,762 effective search space: 3261692714 effective search space used: 3261692714 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.2 bits) S2: 62 (28.5 bits)