BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P92208 (372 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 5AWM-A nrPDB 785 0.0 2XS0-A nrPDB 622 e-179 1JNK-A nrPDB 615 e-177 3FI2-A nrPDB 586 e-168 3E7O-A nrPDB 585 e-168 3GC9-A nrPDB 340 9e-94 4EWQ-A nrPDB 333 6e-92 1CM8-A nrPDB 333 9e-92 3OHT-A nrPDB 329 1e-90 4MYG-A nrPDB 317 6e-87 5NGU-A nrPDB 265 2e-71 4QTB-A nrPDB 258 2e-69 5Z33-A nrPDB 255 2e-68 4IC8-A nrPDB 254 3e-68 6DTL-A nrPDB 253 9e-68 4ZSG-A nrPDB 252 2e-67 2F9G-A nrPDB 218 4e-57 4O2Z-A nrPDB 212 2e-55 3OZ6-A nrPDB 201 4e-52 4QNY-A nrPDB 198 3e-51 3RP9-A nrPDB 196 2e-50 3N9X-A nrPDB 177 8e-45 2I6L-A nrPDB 170 8e-43 3NIZ-A nrPDB 168 3e-42 2BPM-A nrPDB 168 4e-42 3PG1-A nrPDB 168 4e-42 3NIE-A nrPDB 163 1e-40 4E7W-A nrPDB 158 3e-39 1V0B-A nrPDB 154 6e-38 6GU6-A nrPDB 153 1e-37 3EB0-A nrPDB 153 1e-37 3ZDU-A nrPDB 150 1e-36 2W96-B nrPDB 149 3e-36 4AU8-A nrPDB 147 5e-36 4BBM-A nrPDB 147 7e-36 4BGQ-A nrPDB 145 2e-35 1UA2-A nrPDB 144 4e-35 3GC0-A nrPDB 144 7e-35 1G3N-A nrPDB 140 7e-34 4KRC-A nrPDB 140 1e-33 5AIR-A nrPDB 137 1e-32 3E3P-A nrPDB 134 5e-32 5G6V-A nrPDB 132 2e-31 5EFQ-A nrPDB 128 4e-30 4AGU-A nrPDB 127 7e-30 4NST-A nrPDB 125 2e-29 3MIA-A nrPDB 124 9e-29 2YCR-A nrPDB 122 2e-28 5JN2-A nrPDB 122 3e-28 3I6U-A nrPDB 121 4e-28 5Y86-A nrPDB 121 5e-28 3MA6-A nrPDB 119 2e-27 5ZTN-A nrPDB 119 3e-27 4RGJ-A nrPDB 119 3e-27 4IAN-A nrPDB 117 7e-27 4MVF-A nrPDB 117 1e-26 3DFA-A nrPDB 116 1e-26 2WO6-A nrPDB 116 1e-26 3NCG-A nrPDB 116 1e-26 3LIJ-A nrPDB 115 4e-26 4CRL-A nrPDB 112 2e-25 5ES1-A nrPDB 112 2e-25 3HZT-A nrPDB 110 9e-25 4YZB-A nrPDB 110 1e-24 3DXN-A nrPDB 110 1e-24 2JD5-A nrPDB 110 1e-24 5KZ7-A nrPDB 109 2e-24 2QNJ-A nrPDB 108 4e-24 6O6Q-A nrPDB 100 8e-22 3H4J-B nrPDB 100 1e-21 4EQM-A nrPDB 100 1e-21 5XZW-A nrPDB 100 1e-21 5X8I-B nrPDB 100 2e-21 6C9D-A nrPDB 99 3e-21 2HAK-A nrPDB 98 5e-21 2F57-A nrPDB 97 1e-20 3KN6-A nrPDB 97 2e-20 4PDS-A nrPDB 96 2e-20 3Q5I-A nrPDB 96 2e-20 6FYV-A nrPDB 96 2e-20 6FD3-A nrPDB 95 4e-20 3F3Z-A nrPDB 95 5e-20 3Q53-A nrPDB 95 6e-20 4NIF-A nrPDB 95 6e-20 4FIE-A nrPDB 94 9e-20 4B6L-A nrPDB 94 1e-19 4XBR-A nrPDB 94 1e-19 4KS7-A nrPDB 94 1e-19 2Q0N-A nrPDB 94 1e-19 4JDH-A nrPDB 94 1e-19 6HMD-A nrPDB 94 1e-19 4FG9-A nrPDB 93 2e-19 2PVN-A nrPDB 93 2e-19 2VZ6-A nrPDB 93 2e-19 5XVU-A nrPDB 92 3e-19 5D9K-A nrPDB 92 3e-19 4D28-A nrPDB 92 4e-19 4CFH-A nrPDB 92 5e-19 4REW-A nrPDB 92 5e-19 4JG6-A nrPDB 91 6e-19 3IS5-A nrPDB 91 7e-19 3BHH-A nrPDB 91 1e-18 2Z7Q-A nrPDB 90 1e-18 6QAU-A nrPDB 90 2e-18 3RAW-A nrPDB 90 2e-18 6EII-A nrPDB 90 2e-18 6E2O-A nrPDB 89 2e-18 2V7O-A nrPDB 89 3e-18 4APC-A nrPDB 89 3e-18 4I6B-A nrPDB 89 3e-18 4RED-A nrPDB 89 4e-18 5JZN-A nrPDB 88 5e-18 4MD7-E nrPDB 88 5e-18 2WQN-A nrPDB 87 8e-18 5U6Y-A nrPDB 87 1e-17 4WNO-A nrPDB 87 2e-17 4LFI-A nrPDB 86 2e-17 4M7I-A nrPDB 86 2e-17 2W4O-A nrPDB 86 2e-17 4WB7-A nrPDB 86 2e-17 5UNP-A nrPDB 86 3e-17 3DLS-A nrPDB 86 4e-17 3DAK-A nrPDB 85 4e-17 5DYK-A nrPDB 85 5e-17 4CZT-A nrPDB 85 5e-17 5N23-A nrPDB 84 7e-17 5YKS-A nrPDB 84 8e-17 5F9E-A nrPDB 84 9e-17 5X3F-B nrPDB 84 1e-16 5FET-A nrPDB 84 1e-16 4C0T-A nrPDB 84 1e-16 2VN9-A nrPDB 83 1e-16 2JAM-A nrPDB 83 2e-16 4YNZ-A nrPDB 83 2e-16 3SOA-A nrPDB 83 2e-16 4OW8-A nrPDB 83 2e-16 4L42-A nrPDB 83 2e-16 4X3F-A nrPDB 83 2e-16 2JC6-A nrPDB 82 3e-16 4UZD-A nrPDB 82 3e-16 6B2Q-A nrPDB 82 4e-16 5FG8-A nrPDB 82 4e-16 2X4F-A nrPDB 82 4e-16 1ZXE-A nrPDB 82 4e-16 5IG1-A nrPDB 82 4e-16 5EZV-A nrPDB 82 6e-16 4CFF-A nrPDB 81 6e-16 6CQF-A nrPDB 81 7e-16 1U5R-A nrPDB 81 7e-16 6ED6-A nrPDB 81 7e-16 3MN3-A nrPDB 81 7e-16 4TNB-A nrPDB 81 7e-16 3TAC-A nrPDB 81 7e-16 2GCD-A nrPDB 81 7e-16 3D2K-A nrPDB 80 1e-15 3NYO-A nrPDB 80 1e-15 4RLP-A nrPDB 80 1e-15 4FR4-A nrPDB 80 2e-15 6BDL-A nrPDB 80 2e-15 4AF3-A nrPDB 80 2e-15 3VN9-A nrPDB 79 2e-15 3HKO-A nrPDB 79 3e-15 3QD2-B nrPDB 79 3e-15 5X5O-A nrPDB 79 3e-15 3ORZ-A nrPDB 79 3e-15 2BRG-A nrPDB 79 4e-15 6E9W-A nrPDB 78 5e-15 2YZA-A nrPDB 78 5e-15 4B8L-A nrPDB 78 6e-15 5TQX-A nrPDB 78 6e-15 1PHK-A nrPDB 78 8e-15 1KOA-A nrPDB 78 8e-15 3COM-A nrPDB 77 8e-15 5DBX-A nrPDB 77 9e-15 3UC3-A nrPDB 77 9e-15 5H2U-A nrPDB 77 9e-15 5UIU-A nrPDB 77 1e-14 3ORP-A nrPDB 77 1e-14 2J90-A nrPDB 77 1e-14 3KK8-A nrPDB 77 1e-14 3UTO-A nrPDB 77 1e-14 3FXW-A nrPDB 77 1e-14 2Y7J-A nrPDB 77 1e-14 6CMJ-A nrPDB 77 1e-14 4QMW-A nrPDB 77 2e-14 4KIK-B nrPDB 77 2e-14 2BDW-A nrPDB 76 2e-14 4UY9-A nrPDB 76 2e-14 2XNP-A nrPDB 76 2e-14 3PPZ-A nrPDB 76 2e-14 5EG3-A nrPDB 76 2e-14 4YHJ-A nrPDB 76 2e-14 1KOB-A nrPDB 76 3e-14 3C51-A nrPDB 76 3e-14 2UV2-A nrPDB 75 3e-14 4CQG-A nrPDB 75 4e-14 3UDB-A nrPDB 75 4e-14 6AO5-A nrPDB 75 4e-14 3ZUT-A nrPDB 75 5e-14 2A1A-B nrPDB 75 5e-14 4LG4-A nrPDB 75 6e-14 3QA8-A nrPDB 75 6e-14 4GS6-A nrPDB 74 9e-14 5D7A-A nrPDB 74 9e-14 4U41-A nrPDB 74 1e-13 2PSQ-A nrPDB 74 1e-13 2HW6-A nrPDB 74 1e-13 1FOT-A nrPDB 74 1e-13 5WAX-A nrPDB 73 2e-13 2YAB-A nrPDB 73 2e-13 3DTC-A nrPDB 73 2e-13 5LOH-A nrPDB 73 2e-13 1ZWS-A nrPDB 73 2e-13 2A27-A nrPDB 73 2e-13 3UIU-A nrPDB 73 2e-13 5J5T-A nrPDB 73 2e-13 6FDY-U nrPDB 73 2e-13 6CCF-A nrPDB 73 2e-13 4K33-A nrPDB 72 3e-13 3KA0-A nrPDB 72 4e-13 3DB8-A nrPDB 72 4e-13 4UYA-A nrPDB 72 5e-13 2OZA-A nrPDB 72 5e-13 4JXF-A nrPDB 71 6e-13 1NY3-A nrPDB 71 6e-13 4FZF-B nrPDB 71 6e-13 2X7G-A nrPDB 71 7e-13 6CKI-A nrPDB 71 8e-13 2WTK-C nrPDB 71 8e-13 5VO2-A nrPDB 71 9e-13 2OU7-A nrPDB 71 9e-13 3FME-A nrPDB 71 1e-12 3GUB-A nrPDB 70 1e-12 2JDO-A nrPDB 70 1e-12 5YV8-A nrPDB 70 1e-12 4J52-A nrPDB 70 1e-12 3TT0-A nrPDB 70 2e-12 3GQL-A nrPDB 70 2e-12 2XIK-A nrPDB 69 2e-12 4D2V-A nrPDB 69 3e-12 5GRN-A nrPDB 69 4e-12 5A46-A nrPDB 69 4e-12 6HXF-B nrPDB 69 5e-12 6GVJ-A nrPDB 69 5e-12 3TXO-A nrPDB 68 5e-12 1S9I-A nrPDB 68 6e-12 3EQC-A nrPDB 68 7e-12 3HDN-A nrPDB 67 1e-11 4XCU-A nrPDB 67 1e-11 5KCV-A nrPDB 67 1e-11 3TKU-A nrPDB 67 1e-11 2R2P-A nrPDB 67 1e-11 3DKO-A nrPDB 67 1e-11 3HMP-A nrPDB 67 1e-11 5KKR-C nrPDB 67 1e-11 4WUA-A nrPDB 67 1e-11 4IDT-A nrPDB 67 2e-11 3PFQ-A nrPDB 67 2e-11 3A8W-A nrPDB 67 2e-11 3G0E-A nrPDB 67 2e-11 2I0E-A nrPDB 66 2e-11 3MV5-A nrPDB 66 2e-11 3KUL-B nrPDB 66 2e-11 5AP3-A nrPDB 66 2e-11 6HV0-A nrPDB 66 3e-11 3LLT-A nrPDB 66 3e-11 4AN9-A nrPDB 66 3e-11 3LM0-A nrPDB 66 3e-11 2J0K-A nrPDB 66 3e-11 2ZMD-A nrPDB 66 3e-11 4PL5-B nrPDB 65 3e-11 4RA4-A nrPDB 65 4e-11 4AW2-A nrPDB 65 4e-11 1VZO-A nrPDB 65 4e-11 6GQK-A nrPDB 65 4e-11 4G3E-A nrPDB 65 5e-11 3ALO-A nrPDB 65 6e-11 1AD5-A nrPDB 65 7e-11 1JPA-A nrPDB 64 7e-11 3PLS-A nrPDB 64 8e-11 4EBW-A nrPDB 64 8e-11 4C59-A nrPDB 64 9e-11 4CRS-A nrPDB 64 1e-10 5HVK-A nrPDB 64 1e-10 4P5Q-A nrPDB 63 2e-10 4XEY-B nrPDB 63 2e-10 5VD3-A nrPDB 63 2e-10 6NPU-A nrPDB 62 3e-10 2PL0-A nrPDB 62 4e-10 2RIO-A nrPDB 62 4e-10 3CJF-A nrPDB 62 5e-10 4CSV-A nrPDB 62 5e-10 5UUU-A nrPDB 62 5e-10 2XYN-A nrPDB 62 5e-10 6BXI-A nrPDB 62 5e-10 5L6P-A nrPDB 62 6e-10 4E93-A nrPDB 61 6e-10 2W1I-A nrPDB 61 6e-10 1FVR-A nrPDB 61 6e-10 3PVW-A nrPDB 61 7e-10 2FO0-A nrPDB 61 7e-10 5HI2-A nrPDB 61 8e-10 3IO7-A nrPDB 61 8e-10 5HIE-A nrPDB 61 9e-10 4HVI-A nrPDB 61 9e-10 4NEU-A nrPDB 60 1e-09 5O2C-A nrPDB 60 1e-09 4TPT-A nrPDB 60 1e-09 2HK5-A nrPDB 60 1e-09 5TUR-A nrPDB 60 1e-09 5MJB-A nrPDB 60 2e-09 4RC3-A nrPDB 60 2e-09 3A4O-X nrPDB 60 2e-09 2BUJ-A nrPDB 60 2e-09 5X02-A nrPDB 60 2e-09 4X7Q-B nrPDB 60 2e-09 4XI2-A nrPDB 60 2e-09 4PDO-A nrPDB 60 2e-09 4NFN-A nrPDB 59 3e-09 2VWV-A nrPDB 59 3e-09 5O2B-A nrPDB 59 3e-09 4BTK-A nrPDB 59 3e-09 2H8H-A nrPDB 59 3e-09 3BGP-A nrPDB 59 3e-09 2H34-A nrPDB 59 3e-09 1TKI-A nrPDB 59 4e-09 4PWN-A nrPDB 59 4e-09 2OGV-A nrPDB 59 4e-09 3OMV-A nrPDB 59 4e-09 4Y93-A nrPDB 59 4e-09 4XUF-A nrPDB 59 4e-09 2Y6O-A nrPDB 59 5e-09 6F3F-A nrPDB 58 5e-09 6E4F-A nrPDB 58 6e-09 3SXS-A nrPDB 58 6e-09 2DQ7-X nrPDB 58 6e-09 5SYS-A nrPDB 58 7e-09 6CTH-A nrPDB 58 8e-09 6J5U-C nrPDB 58 8e-09 4JLC-A nrPDB 57 1e-08 5B2L-A nrPDB 57 2e-08 4AT3-A nrPDB 57 2e-08 4OTD-A nrPDB 57 2e-08 6DBN-A nrPDB 57 2e-08 3HNG-A nrPDB 56 2e-08 4Y83-A nrPDB 56 2e-08 3BEA-A nrPDB 56 2e-08 3MY0-A nrPDB 56 3e-08 4EUT-A nrPDB 56 3e-08 3V5Q-A nrPDB 56 3e-08 5O0Y-A nrPDB 55 3e-08 6NT9-A nrPDB 55 4e-08 4EUU-A nrPDB 55 5e-08 6O8B-A nrPDB 55 5e-08 5E8V-A nrPDB 55 5e-08 3QGY-A nrPDB 55 6e-08 3KRL-A nrPDB 55 6e-08 1K9A-A nrPDB 55 6e-08 3Q4U-A nrPDB 55 7e-08 5GNK-A nrPDB 54 8e-08 4RT7-A nrPDB 54 8e-08 3SOC-A nrPDB 54 1e-07 5WNO-A nrPDB 54 1e-07 1BYG-A nrPDB 54 1e-07 3VHK-A nrPDB 53 2e-07 5HLW-A nrPDB 53 2e-07 4M66-A nrPDB 53 2e-07 5TE0-A nrPDB 53 2e-07 3ZZW-A nrPDB 53 3e-07 3C1X-A nrPDB 52 3e-07 4R7H-A nrPDB 52 3e-07 5TOS-A nrPDB 52 3e-07 3G2F-A nrPDB 52 4e-07 3QUP-A nrPDB 52 4e-07 5FQD-C nrPDB 52 4e-07 4XHL-A nrPDB 52 4e-07 2QKW-B nrPDB 52 4e-07 5FM2-A nrPDB 52 4e-07 5C26-A nrPDB 52 4e-07 3LZB-A nrPDB 52 4e-07 5U6B-A nrPDB 52 4e-07 3M42-A nrPDB 52 4e-07 6FER-A nrPDB 52 4e-07 5AMN-A nrPDB 52 6e-07 4FL3-A nrPDB 51 9e-07 3MDY-A nrPDB 51 9e-07 5X1R-A nrPDB 51 1e-06 4XHH-A nrPDB 50 1e-06 5KMM-A nrPDB 50 1e-06 5IKW-A nrPDB 50 1e-06 1PY5-A nrPDB 50 1e-06 4OLI-A nrPDB 50 1e-06 6DBM-A nrPDB 50 2e-06 4CI6-B nrPDB 50 2e-06 1U59-A nrPDB 50 2e-06 4LRM-A nrPDB 50 2e-06 4E20-A nrPDB 50 2e-06 6FEX-A nrPDB 50 2e-06 3SV0-A nrPDB 50 2e-06 2OZO-A nrPDB 49 3e-06 3PP0-A nrPDB 49 3e-06 6BSD-A nrPDB 49 4e-06 5J0A-A nrPDB 49 5e-06 5OAT-A nrPDB 49 5e-06 4XLV-A nrPDB 48 6e-06 4JRN-A nrPDB 48 6e-06 1LUF-A nrPDB 48 7e-06 2QLU-A nrPDB 47 9e-06 3BBT-B nrPDB 47 1e-05 2VD5-A nrPDB 47 1e-05 4HZS-A nrPDB 47 1e-05 2PMN-X nrPDB 47 2e-05 3I81-A nrPDB 47 2e-05 1U54-B nrPDB 46 2e-05 4LQP-A nrPDB 46 2e-05 5XD6-A nrPDB 46 2e-05 1CSN-A nrPDB 45 4e-05 4TN6-A nrPDB 45 5e-05 2PZI-A nrPDB 45 7e-05 5U6C-A nrPDB 44 8e-05 4Y12-A nrPDB 44 9e-05 4F9B-A nrPDB 44 1e-04 5LPV-A nrPDB 44 1e-04 5LPZ-A nrPDB 44 1e-04 5CLR-A nrPDB 44 2e-04 5AR8-A nrPDB 44 2e-04 4H1J-A nrPDB 44 2e-04 4F0G-A nrPDB 43 2e-04 2WTK-B nrPDB 42 3e-04 3UIM-A nrPDB 42 3e-04 5WNL-A nrPDB 42 5e-04 5VC6-A nrPDB 42 5e-04 5L2Q-C nrPDB 41 9e-04 3ZBF-A nrPDB 41 0.001 4M69-B nrPDB 41 0.001 4BTF-A nrPDB 40 0.001 3LMG-A nrPDB 40 0.002 4IX6-A nrPDB 40 0.002 5X18-A nrPDB 39 0.002 2Y4I-B nrPDB 39 0.002 2CMW-A nrPDB 39 0.003 2C47-A nrPDB 39 0.003 5VDK-A nrPDB 39 0.003 2CHL-A nrPDB 39 0.004 6G4J-A nrPDB 38 0.009 5VE6-A nrPDB 37 0.009 4NT4-A nrPDB 37 0.012 3AOX-A nrPDB 37 0.012 6EQI-C nrPDB 36 0.023 4L68-A nrPDB 36 0.025 6EWX-A nrPDB 35 0.038 6M7Z-A nrPDB 35 0.040 4YFF-A nrPDB 35 0.043 4AZV-A nrPDB 35 0.050 6BFN-A nrPDB 35 0.051 4AZW-A nrPDB 35 0.055 6FAI-l nrPDB 33 0.17 6J6I-B nrPDB 33 0.22 3ENH-A nrPDB 33 0.26 6DC0-A nrPDB 33 0.28 5CEK-A nrPDB 32 0.32 5M07-A nrPDB 32 0.49 4O1O-A nrPDB 31 0.70 1LLQ-A nrPDB 31 1.0 6MC8-A nrPDB 30 1.5 4OAU-C nrPDB 30 1.8 5DMZ-A nrPDB 30 1.9 2OR0-A nrPDB 30 2.2 5DLD-A nrPDB 30 2.3 3Q60-A nrPDB 29 2.7 1Z3I-X nrPDB 28 4.7 2KC5-A nrPDB 28 5.3 1H4P-A nrPDB 28 8.4 5UU1-A nrPDB 28 9.2 >5AWM-A nrPDB Length = 394 Score = 785 bits (2027), Expect = 0.0, Method: Compositional matrix adjust. Identities = 372/372 (100%), Positives = 372/372 (100%) Query: 1 MTTAQHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQ 60 MTTAQHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQ Sbjct: 23 MTTAQHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQ 82 Query: 61 NVTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMD 120 NVTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMD Sbjct: 83 NVTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMD 142 Query: 121 LDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMM 180 LDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMM Sbjct: 143 LDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMM 202 Query: 181 TPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLG 240 TPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLG Sbjct: 203 TPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLG 262 Query: 241 TPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKM 300 TPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKM Sbjct: 263 TPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKM 322 Query: 301 LVIDPEQRISVDEALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYEEVM 360 LVIDPEQRISVDEALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYEEVM Sbjct: 323 LVIDPEQRISVDEALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYEEVM 382 Query: 361 DYEAHNTNNRTR 372 DYEAHNTNNRTR Sbjct: 383 DYEAHNTNNRTR 394 >2XS0-A nrPDB Length = 386 Score = 622 bits (1605), Expect = e-179, Method: Compositional matrix adjust. Identities = 288/364 (79%), Positives = 321/364 (88%), Gaps = 1/364 (0%) Query: 9 YTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRA 68 Y+VE+GD+ FT+ RY NL+PIGSGAQGIVCAAYD I ++NVAIKKLSRPFQN THAKRA Sbjct: 13 YSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRA 72 Query: 69 YREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSY 128 YRE LMK VNHKNIIGLLN FTPQ++LEEFQDVY+VMELMDANLCQVIQM+LDH+RMSY Sbjct: 73 YRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHERMSY 132 Query: 129 LLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRY 188 LLYQMLCGIKHLHSAGIIHRDLKPSNIVVK+DCTLKILDFGLARTAGT+FMM P+VVTRY Sbjct: 133 LLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMVPFVVTRY 192 Query: 189 YRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQ 248 YRAPEVILGMGY ENVDIWSVGCIMGEMI+GGVLFPGTDHIDQWNK+IEQLGTP P FM+ Sbjct: 193 YRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMK 252 Query: 249 RLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQR 308 +LQPTVR YVENRP+Y GYSF++LFPD LFP D+ N + KAS AR+LLSKMLVID +R Sbjct: 253 KLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHN-KLKASQARDLLSKMLVIDASKR 311 Query: 309 ISVDEALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYEEVMDYEAHNTN 368 ISVDEAL+H YINVWYD E +AP P+ D +DEREHT+E+WKELIY+EVMD E N Sbjct: 312 ISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLEERTKN 371 Query: 369 NRTR 372 R Sbjct: 372 GVIR 375 >1JNK-A nrPDB Length = 423 Score = 615 bits (1587), Expect = e-177, Method: Compositional matrix adjust. Identities = 285/371 (76%), Positives = 321/371 (86%), Gaps = 1/371 (0%) Query: 2 TTAQHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQN 61 + +Q Y+VEVGD+ FT+ RY NL+PIGSGAQGIVCAAYD + +NVAIKKLSRPFQN Sbjct: 42 SKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQN 101 Query: 62 VTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDL 121 THAKRAYRE LMK VNHKNII LLN FTPQ+ LEEFQDVYLVMELMDANLCQVIQM+L Sbjct: 102 QTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMEL 161 Query: 122 DHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMT 181 DH+RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK+DCTLKILDFGLARTAGT+FMMT Sbjct: 162 DHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMT 221 Query: 182 PYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGT 241 PYVVTRYYRAPEVILGMGY ENVDIWSVGCIMGEM+R +LFPG D+IDQWNK+IEQLGT Sbjct: 222 PYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGT 281 Query: 242 PSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKML 301 P P FM++LQPTVRNYVENRP+Y G +F +LFPD LFP D+ N + KAS AR+LLSKML Sbjct: 282 PCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHN-KLKASQARDLLSKML 340 Query: 302 VIDPEQRISVDEALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYEEVMD 361 VIDP +RISVD+AL+H YINVWYD EV+AP P+ YD +DEREHT+E+WKELIY+EVM+ Sbjct: 341 VIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMN 400 Query: 362 YEAHNTNNRTR 372 E N + Sbjct: 401 SEEKTKNGVVK 411 >3FI2-A nrPDB Length = 353 Score = 586 bits (1510), Expect = e-168, Method: Compositional matrix adjust. Identities = 276/362 (76%), Positives = 308/362 (85%), Gaps = 12/362 (3%) Query: 2 TTAQHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQN 61 + +Q Y+VEVGD+ FT+ RY NL+PIGSGAQGIVCAAYD + +NVAIKKLSRPFQN Sbjct: 4 SKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQN 63 Query: 62 VTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDL 121 THAKRAYRE LMK VNHKNII LLN FTPQ+ LEEFQDVYLVMELMDANLCQVIQM+L Sbjct: 64 QTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMEL 123 Query: 122 DHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMT 181 DH+RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK+DCTLKILDFGLARTAGT+FMMT Sbjct: 124 DHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMT 183 Query: 182 PYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGT 241 PYVVTRYYRAPEVILGMGY ENVDIWSVGCIMGEM+R +LFPG D+IDQWNK+IEQLGT Sbjct: 184 PYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGT 243 Query: 242 PSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKML 301 P P FM++LQPTVRNYVENRP+Y G +F +LFPD LFP D+ N + KAS AR+LLSKML Sbjct: 244 PCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHN-KLKASQARDLLSKML 302 Query: 302 VIDPEQRISVDEALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYEEVMD 361 VIDP +RISVD+AL+H YINVWY DEREHT+E+WKELIY+EVM+ Sbjct: 303 VIDPAKRISVDDALQHPYINVWYXXXX-----------XXDEREHTIEEWKELIYKEVMN 351 Query: 362 YE 363 E Sbjct: 352 SE 353 >3E7O-A nrPDB Length = 360 Score = 585 bits (1509), Expect = e-168, Method: Compositional matrix adjust. Identities = 270/355 (76%), Positives = 308/355 (86%), Gaps = 1/355 (0%) Query: 7 QHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAK 66 Q Y+V+V D+ FT+ RY L+PIGSGAQGIVCAA+DT+ NVA+KKLSRPFQN THAK Sbjct: 7 QFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAK 66 Query: 67 RAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRM 126 RAYRE L+K VNHKNII LLN FTPQ+ LEEFQDVYLVMELMDANLCQVI M+LDH+RM Sbjct: 67 RAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERM 126 Query: 127 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVT 186 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK+DCTLKILDFGLARTA T FMMTPYVVT Sbjct: 127 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTASTNFMMTPYVVT 186 Query: 187 RYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSF 246 RYYRAPEVILGMGY ENVDIWSVGCIMGE+++G V+F GTDHIDQWNK+IEQLGTPS F Sbjct: 187 RYYRAPEVILGMGYKENVDIWSVGCIMGELVKGSVIFQGTDHIDQWNKVIEQLGTPSAEF 246 Query: 247 MQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPE 306 M LQPTVRNYVENRP Y G +F+ LFPD +FP+++ ++ + K S AR+LLSKMLVIDP+ Sbjct: 247 MAALQPTVRNYVENRPAYPGIAFEELFPDWIFPSESERD-KIKTSQARDLLSKMLVIDPD 305 Query: 307 QRISVDEALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYEEVMD 361 +RISVDEAL+H YI VWYD E +AP P+ YD ++EREH +E+WKELIY+EVMD Sbjct: 306 KRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMD 360 >3GC9-A nrPDB Length = 370 Score = 340 bits (871), Expect = 9e-94, Method: Compositional matrix adjust. Identities = 170/365 (46%), Positives = 240/365 (65%), Gaps = 20/365 (5%) Query: 1 MTTAQHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQ 60 M+ + Y E+ T + + R LRP+GSGA G VC+AYD +Q VA+KKLSRPFQ Sbjct: 7 MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQ 66 Query: 61 NVTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMD 120 ++ HA+R YRE +L+K + H+N+IGLL+ FTP ++E+F +VYLV LM A+L +++ Sbjct: 67 SLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKSQ 126 Query: 121 -LDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFM 179 L + + +L+YQ+L G+K++HSAGIIHRDLKPSN+ V D L+ILDFGLAR A Sbjct: 127 ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDSELRILDFGLARQADEE-- 184 Query: 180 MTPYVVTRYYRAPEVILG-MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQ 238 MT YV TR+YRAPE++L M Y + VDIWSVGCIM E+++G LFPG+D+IDQ +I+E Sbjct: 185 MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEV 244 Query: 239 LGTPSPSFMQRLQPT-VRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLL 297 +GTPSP + ++ R Y+++ P +F R A +LL Sbjct: 245 VGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIF-------------RGANPLAIDLL 291 Query: 298 SKMLVIDPEQRISVDEALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYE 357 +MLV+D +QR+S EAL H Y + ++D E D P EPYD SV+ +E T+E+WKEL Y+ Sbjct: 292 GRMLVLDSDQRVSAAEALAHAYFSQYHDPE--DEPEAEPYDESVEAKERTLEEWKELTYQ 349 Query: 358 EVMDY 362 EV+ + Sbjct: 350 EVLSF 354 >4EWQ-A nrPDB Length = 383 Score = 333 bits (855), Expect = 6e-92, Method: Compositional matrix adjust. Identities = 172/357 (48%), Positives = 236/357 (66%), Gaps = 20/357 (5%) Query: 9 YTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRA 68 Y E+ T + + RY NL P+GSGA G VCAA+DT T VA+KKLSRPFQ++ HAKR Sbjct: 32 YRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRT 91 Query: 69 YREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQ-MDLDHDRMS 127 YRE +L+K + H+N+IGLL+ FTP R+LEEF DVYLV LM A+L +++ L D + Sbjct: 92 YRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQ 151 Query: 128 YLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTR 187 +L+YQ+L G+K++HSA IIHRDLKPSN+ V DC LKILDFGLAR T MT YV TR Sbjct: 152 FLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDEMTGYVATR 209 Query: 188 YYRAPEVILG-MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSF 246 +YRAPE++L M Y + VDIWSVGCIM E++ G LFPGTDHIDQ I+ +GTP Sbjct: 210 WYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAEL 269 Query: 247 MQRLQP-TVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDP 305 ++++ + RNY+++ + +F +F G P A +LL KMLV+D Sbjct: 270 LKKISSESARNYIQSLTQMPKMNFANVFI-GANPL------------AVDLLEKMLVLDS 316 Query: 306 EQRISVDEALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYEEVMDY 362 ++RI+ +AL H Y ++D + D P +PYD S + R+ +++WK L Y+EV+ + Sbjct: 317 DKRITAAQALAHAYFAQYHDPD--DEPVADPYDQSFESRDLLIDEWKSLTYDEVISF 371 >1CM8-A nrPDB Length = 367 Score = 333 bits (853), Expect = 9e-92, Method: Compositional matrix adjust. Identities = 173/363 (47%), Positives = 235/363 (64%), Gaps = 20/363 (5%) Query: 4 AQHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVT 63 A+ Y EV T + + + Y +L+P+GSGA G VC+A D T VAIKKL RPFQ+ Sbjct: 7 ARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSEL 66 Query: 64 HAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMD-LD 122 AKRAYRE +L+K + H+N+IGLL+ FTP L++F D YLVM M +L ++++ + L Sbjct: 67 FAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLG 126 Query: 123 HDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTP 182 DR+ +L+YQML G++++H+AGIIHRDLKP N+ V DC LKILDFGLAR A + MT Sbjct: 127 EDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE--MTG 184 Query: 183 YVVTRYYRAPEVILG-MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGT 241 YVVTR+YRAPEVIL M YT+ VDIWSVGCIM EMI G LF G+DH+DQ +I++ GT Sbjct: 185 YVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGT 244 Query: 242 PSPSFMQRLQP-TVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKM 300 P F+QRLQ +NY++ P F + + + A NLL KM Sbjct: 245 PPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNA-------------SPLAVNLLEKM 291 Query: 301 LVIDPEQRISVDEALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYEEVM 360 LV+D EQR++ EAL H Y +D E D P + YD S D+ + T+++WK + Y+EV+ Sbjct: 292 LVLDAEQRVTAGEALAHPYFESLHDTE--DEPQVQKYDDSFDDVDRTLDEWKRVTYKEVL 349 Query: 361 DYE 363 ++ Sbjct: 350 SFK 352 >3OHT-A nrPDB Length = 389 Score = 329 bits (843), Expect = 1e-90, Method: Compositional matrix adjust. Identities = 173/358 (48%), Positives = 232/358 (64%), Gaps = 20/358 (5%) Query: 9 YTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRA 68 Y E+ T + + RY L P+GSGA G VC++YD + +A+KKLSRPFQ++ HAKR Sbjct: 38 YRQELNKTIWEVPERYQTLSPVGSGAYGSVCSSYDVKSGLKIAVKKLSRPFQSIIHAKRT 97 Query: 69 YREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQ-MDLDHDRMS 127 YRE +L+K + H+N+IGLL+ FTP +LEEF DVYLV LM A+L +++ L D + Sbjct: 98 YRELRLLKHMKHENVIGLLDVFTPATSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQ 157 Query: 128 YLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTR 187 +L+YQ+L G+K++HSA IIHRDLKPSN+ V DC LKILDFGLAR T MT YV TR Sbjct: 158 FLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDEMTGYVATR 215 Query: 188 YYRAPEVILG-MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSF 246 +YRAPE++L M Y VDIWSVGCIM E++ G LFPGTDHI+Q +I+ GTP S Sbjct: 216 WYRAPEIMLNWMHYNMTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPASV 275 Query: 247 MQRLQP-TVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDP 305 + R+ RNY+ + P+ +F +F G P A +LL KMLV+D Sbjct: 276 ISRMPSHEARNYINSLPQMPKRNFADVF-IGANPL------------AVDLLEKMLVLDT 322 Query: 306 EQRISVDEALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYEEVMDYE 363 ++RI+ EAL H Y + ++D + D P EPYD S + R+ +E+WK L YEEV +E Sbjct: 323 DKRITASEALAHPYFSQYHDPD--DEPESEPYDQSFESRQLEIEEWKRLTYEEVCSFE 378 >4MYG-A nrPDB Length = 372 Score = 317 bits (812), Expect = 6e-87, Method: Compositional matrix adjust. Identities = 159/356 (44%), Positives = 231/356 (64%), Gaps = 18/356 (5%) Query: 9 YTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRA 68 Y +V T + + Y++ +GSGA G VC+A D + + VAIKKLSRPFQ+ AKRA Sbjct: 30 YKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRA 89 Query: 69 YREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSY 128 YRE L+K + H+N+IGLL+ FTP +L F D YLVM M +L +++ M+ +++ Y Sbjct: 90 YRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQY 149 Query: 129 LLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRY 188 L+YQML G+K++HSAG++HRDLKP N+ V DC LKILDFGLAR A MT YVVTR+ Sbjct: 150 LVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE--MTGYVVTRW 207 Query: 189 YRAPEVILG-MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFM 247 YRAPEVIL M Y + VDIWSVGCIM EM+ G LF G D++DQ +I++ G P F+ Sbjct: 208 YRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFV 267 Query: 248 QRLQ-PTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPE 306 Q+L ++Y+++ P+ F +LFP R + A +LL KML +D + Sbjct: 268 QKLNDKAAKSYIQSLPQTPRKDFTQLFP-------------RASPQAADLLEKMLELDVD 314 Query: 307 QRISVDEALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYEEVMDY 362 +R++ +AL H + + D EE + A +P+D S++ + TV++WK+ IY+E++++ Sbjct: 315 KRLTAAQALTHPFFEPFRDPEE-ETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNF 369 >5NGU-A nrPDB Length = 381 Score = 265 bits (677), Expect = 2e-71, Method: Compositional matrix adjust. Identities = 147/354 (41%), Positives = 220/354 (62%), Gaps = 25/354 (7%) Query: 18 FTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKL 77 F + RY NL IG GA G+VC+AYD + + VAIKK+S PF++ T+ +R RE K++ Sbjct: 38 FDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKIS-PFEHQTYCQRTLREIKILLR 96 Query: 78 VNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMD-LDHDRMSYLLYQMLCG 136 H+NIIG+ N +E+ +DVY+V +LM+ +L ++++ L +D + Y LYQ+L G Sbjct: 97 FRHENIIGI-NDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRG 155 Query: 137 IKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGT----TFMMTPYVVTRYYRAP 192 +K++HSA ++HRDLKPSN+++ C LKI DFGLAR A T +T YV TR+YRAP Sbjct: 156 LKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAP 215 Query: 193 EVIL-GMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQR-L 250 E++L GYT+++DIWSVGCI+ EM+ +FPG ++DQ N I+ LG+PS + + Sbjct: 216 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 275 Query: 251 QPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRIS 310 RNY+ + P ++RLFP+ S A +LL KML +P +RI Sbjct: 276 NLKARNYLLSLPHKNKVPWNRLFPNA-------------DSKALDLLDKMLTFNPHKRIE 322 Query: 311 VDEALKHEYINVWYD-AEEVDAPAPEPYDHSVDEREHTVEQWKELIYEEVMDYE 363 V++AL H Y+ +YD ++E A AP +D +D+ E+ KELI+EE ++ Sbjct: 323 VEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPK--EKLKELIFEETARFQ 374 >4QTB-A nrPDB Length = 380 Score = 258 bits (660), Expect = 2e-69, Method: Compositional matrix adjust. Identities = 141/354 (39%), Positives = 220/354 (62%), Gaps = 25/354 (7%) Query: 18 FTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKL 77 F + RY L+ IG GA G+V +AYD + + VAIKK+S PF++ T+ +R RE +++ Sbjct: 37 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLR 95 Query: 78 VNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQ-MDLDHDRMSYLLYQMLCG 136 H+N+IG+ + LE +DVY+V +LM+ +L ++++ L +D + Y LYQ+L G Sbjct: 96 FRHENVIGIRDILRAS-TLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRG 154 Query: 137 IKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGT----TFMMTPYVVTRYYRAP 192 +K++HSA ++HRDLKPSN+++ C LKI DFGLAR A T +T YV TR+YRAP Sbjct: 155 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 214 Query: 193 EVIL-GMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQR-L 250 E++L GYT+++DIWSVGCI+ EM+ +FPG ++DQ N I+ LG+PS + + Sbjct: 215 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 274 Query: 251 QPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRIS 310 RNY+++ P T ++ +LFP + S A +LL +ML +P +RI+ Sbjct: 275 NMKARNYLQSLPSKTKVAWAKLFP-------------KSDSKALDLLDRMLTFNPNKRIT 321 Query: 311 VDEALKHEYINVWYDAEEVDAP-APEPYDHSVDEREHTVEQWKELIYEEVMDYE 363 V+EAL H Y+ +YD D P A EP+ +++ + E+ KELI++E ++ Sbjct: 322 VEEALAHPYLEQYYDP--TDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQ 373 >5Z33-A nrPDB Length = 425 Score = 255 bits (652), Expect = 2e-68, Method: Compositional matrix adjust. Identities = 147/362 (40%), Positives = 213/362 (58%), Gaps = 29/362 (8%) Query: 12 EVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYRE 71 +V + +F + RY + +G GA GIVCAA + T + VAIKK++ F AKRA RE Sbjct: 21 KVFNQDFIVDERYTVTKELGQGAYGIVCAAVNNQTSEGVAIKKVTNVFSKKILAKRALRE 80 Query: 72 FKLMK-LVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQ--MDLDHDRMSY 128 KL++ H+NI L + P+ + F + YL ELM+ +L +I+ L Sbjct: 81 IKLLQHFRGHRNITCLYDMDIPRPD--NFNETYLYEELMECDLAAIIRSGQPLTDAHFQS 138 Query: 129 LLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGT-----TFMMTPY 183 +YQ+LCG+K++HSA ++HRDLKP N++V ADC LKI DFGLAR MT Y Sbjct: 139 FIYQILCGLKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSVDPEENAGYMTEY 198 Query: 184 VVTRYYRAPEVILGM-GYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTP 242 V TR+YRAPE++L YT+ +D+WSVGCI+ E++ G F G D++DQ N+I+ LGTP Sbjct: 199 VATRWYRAPEIMLSFQSYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQILHILGTP 258 Query: 243 SPSFMQRL-QPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKML 301 + + R+ P + YV N P + + FP LFPN N DA +LL +ML Sbjct: 259 NEETLSRIGSPRAQEYVRNLP----FMAKKPFPT-LFPNAN--------PDALDLLDRML 305 Query: 302 VIDPEQRISVDEALKHEYINVWYDA-EEVDAPAPEPYDHSVDEREHTVEQWKELIYEEVM 360 DP RISV++AL+H Y+++W+DA +E D P +D V E V + +++I +EV Sbjct: 306 AFDPSSRISVEQALEHPYLHIWHDASDEPDCPTTFNFDFEVVE---DVGEMRKMILDEVY 362 Query: 361 DY 362 + Sbjct: 363 RF 364 >4IC8-A nrPDB Length = 442 Score = 254 bits (650), Expect = 3e-68, Method: Compositional matrix adjust. Identities = 144/367 (39%), Positives = 214/367 (58%), Gaps = 27/367 (7%) Query: 15 DTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKL 74 D F + Y + IG+GA G+V +A +T Q VAIKK+ F VT+AKR RE K+ Sbjct: 48 DVTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKI 107 Query: 75 MKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQ----MDLDHDRMSYLL 130 +K H NII + + P EF+ VY+V++LM+++L Q+I + L+H R Y L Sbjct: 108 LKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVR--YFL 165 Query: 131 YQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTT-----FMMTPYVV 185 YQ+L G+K++HSA +IHRDLKPSN++V +C LKI DFG+AR T+ + MT YV Sbjct: 166 YQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVA 225 Query: 186 TRYYRAPEVILGM-GYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSP 244 TR+YRAPE++L + YT+ +D+WSVGCI GEM+ LFPG +++ Q I+ LGTPSP Sbjct: 226 TRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSP 285 Query: 245 SFMQRLQPT-VRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVI 303 + +Q + VR Y+++ P ++ ++P A +LL +ML Sbjct: 286 AVIQAVGAERVRAYIQSLPPRQPVPWETVYPGA-------------DRQALSLLGRMLRF 332 Query: 304 DPEQRISVDEALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYEEVMDYE 363 +P RIS AL+H ++ ++D ++ AP P+D + D T E+ KE I E+ D+ Sbjct: 333 EPSARISAAAALRHPFLAKYHDPDDEPDCAP-PFDFAFDREALTRERIKEAIVAEIEDFH 391 Query: 364 AHNTNNR 370 A R Sbjct: 392 ARREGIR 398 >6DTL-A nrPDB Length = 364 Score = 253 bits (646), Expect = 9e-68, Method: Compositional matrix adjust. Identities = 142/343 (41%), Positives = 205/343 (59%), Gaps = 26/343 (7%) Query: 27 LRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGL 86 + PIG GA GIVC+A ++ T ++VAIKK++ F N AKR RE KL++ ++H+NI+ + Sbjct: 35 IMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAI 94 Query: 87 LNAFTPQ-RNLEEFQDVYLVMELMDANLCQVIQMD--LDHDRMSYLLYQMLCGIKHLHSA 143 + P RN F DVY+ ELMD +L Q+I+ + L + Y LYQ+L G+K++HSA Sbjct: 95 RDIIPPPLRN--AFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSA 152 Query: 144 GIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMG-YTE 202 ++HRDLKPSN+++ A+C LKI DFGLAR + MT YVVTR+YRAPE++L YT Sbjct: 153 NVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTA 212 Query: 203 NVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENRP 262 +D+WSVGCI E++ LFPG DH+ Q ++E +GTPS ++ L + Y+ P Sbjct: 213 AIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLP 272 Query: 263 RYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEYINV 322 Y S FP + P A +L+ KML DP +RI+V +AL H Y+N Sbjct: 273 PYPRQSITDKFP-TVHPL------------AIDLIEKMLTFDPRRRITVLDALAHPYLNS 319 Query: 323 WYDAEEVDAPAPE---PYDHSVDEREHTVEQWKELIYEEVMDY 362 +D + PE P++ + + EQ KELIY E + + Sbjct: 320 LHDISD----EPECTIPFNFDFENHALSEEQMKELIYREALAF 358 >4ZSG-A nrPDB Length = 347 Score = 252 bits (643), Expect = 2e-67, Method: Compositional matrix adjust. Identities = 142/360 (39%), Positives = 212/360 (58%), Gaps = 27/360 (7%) Query: 16 TNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLM 75 F + Y + IG+GA G+V +A +T Q VAIKK+ F VT+AKR RE K++ Sbjct: 1 VTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKIL 60 Query: 76 KLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQ----MDLDHDRMSYLLY 131 K H NII + + P EF+ VY+V++LM+++L Q+I + L+H R Y LY Sbjct: 61 KHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVR--YFLY 118 Query: 132 QMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTT-----FMMTPYVVT 186 Q+L G+K++HSA +IHRDLKPSN++V +C LKI DFG+AR T+ + MT YV T Sbjct: 119 QLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVAT 178 Query: 187 RYYRAPEVILGM-GYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPS 245 R+YRAPE++L + YT+ +D+WSVGCI GEM+ LFPG +++ Q I+ LGTPSP+ Sbjct: 179 RWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPA 238 Query: 246 FMQRL-QPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVID 304 +Q + VR Y+++ P ++ ++P A +LL +ML + Sbjct: 239 VIQAVGAERVRAYIQSLPPRQPVPWETVYPGA-------------DRQALSLLGRMLRFE 285 Query: 305 PEQRISVDEALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYEEVMDYEA 364 P RIS AL+H ++ ++D ++ AP P+D + D T E+ KE I E+ D+ A Sbjct: 286 PSARISAAAALRHPFLAKYHDPDDEPDCAP-PFDFAFDREALTRERIKEAIVAEIEDFHA 344 >2F9G-A nrPDB Length = 353 Score = 218 bits (554), Expect = 4e-57, Method: Compositional matrix adjust. Identities = 131/351 (37%), Positives = 186/351 (52%), Gaps = 37/351 (10%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNA 89 +G GA G+VC+A T + VAIKK+ PF A R RE K++K H+NII + N Sbjct: 19 LGEGAYGVVCSATHKPTGEIVAIKKIE-PFDKPLFALRTLREIKILKHFKHENIITIFNI 77 Query: 90 FTPQRNLEEFQDVYLVMELMDANLCQVIQMD-LDHDRMSYLLYQMLCGIKHLHSAGIIHR 148 P + E F +VY++ ELM +L +VI L D + Y +YQ L +K LH + +IHR Sbjct: 78 QRPD-SFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNVIHR 136 Query: 149 DLKPSNIVVKADCTLKILDFGLART-----------AGTTFMMTPYVVTRYYRAPEVIL- 196 DLKPSN+++ ++C LK+ DFGLAR G MT YV TR+YRAPEV+L Sbjct: 137 DLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLT 196 Query: 197 GMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRL--QPTV 254 Y+ +D+WS GCI+ E+ +FPG D+ Q I +GTP R P Sbjct: 197 SAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRA 256 Query: 255 RNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEA 314 R Y+++ P Y +++FP R +LL +MLV DP +RI+ EA Sbjct: 257 REYIKSLPMYPAAPLEKMFP-------------RVNPKGIDLLQRMLVFDPAKRITAKEA 303 Query: 315 LKHEYINVWYDAEEVDAPAPEPYDHSVDEREH-----TVEQWKELIYEEVM 360 L+H Y+ ++D D P EP S E +H T + K+LI+ E+ Sbjct: 304 LEHPYLQTYHDPN--DEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNEIF 352 >4O2Z-A nrPDB Length = 377 Score = 212 bits (540), Expect = 2e-55, Method: Compositional matrix adjust. Identities = 120/357 (33%), Positives = 193/357 (54%), Gaps = 24/357 (6%) Query: 13 VGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREF 72 V + F + S+Y L+ +G GA GI C+ D T + V+IKK F++V KR RE Sbjct: 36 VSGSPFEVPSKYTLLKILGMGAYGIACSCLDGDTGEKVSIKKCRDVFRDVEDGKRVLREI 95 Query: 73 KLMKLVNHKNIIGLLNAFTP-QRNLEEFQDVYLVMELMDANLCQVIQMD--LDHDRMSYL 129 +M+ +H+N++ ++N P +R F+DVY+V LMD ++ V++ L+ M Y Sbjct: 96 DMMRFFHHENLLNVVNILPPLKREYHSFEDVYVVTPLMDVDMNVVLRSRQVLEESHMQYF 155 Query: 130 LYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFM-MTPYVVTRY 188 +YQ+L G+K+LHSA + HRDLKP+N+V C LKI+DFGL+R+ + +T YV+TR+ Sbjct: 156 VYQILRGLKYLHSANVAHRDLKPANLVTNISCELKIIDFGLSRSVDVPYSELTDYVITRW 215 Query: 189 YRAPEVIL-GMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFM 247 YR PE++L Y+ VDIWSVGCI EM +FPG + +DQ I + +G P S + Sbjct: 216 YRPPELLLENTNYSTAVDIWSVGCIFAEMYNRKPVFPGRNTMDQLRMIAQHIGKPPASIV 275 Query: 248 QRLQPTVRNYVENRPRYTGYSFDRL--FPDGLFPNDNNQNSRRKASDARNLLSKMLVIDP 305 + + + ++L PDG ++ + LSKM +DP Sbjct: 276 EHRE----------------ALEKLNELPDGSLNIPKLVPGLAGNTEGIDFLSKMWTLDP 319 Query: 306 EQRISVDEALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYEEVMDY 362 +R + + L H Y+ +D EE + P P+ + + V + + + +++DY Sbjct: 320 SKRPTAADMLAHPYLAHLHD-EEDEPTCPCPFLWAHESTPMGVSELRRAFWADIVDY 375 >3OZ6-A nrPDB Length = 388 Score = 201 bits (511), Expect = 4e-52, Method: Compositional matrix adjust. Identities = 125/376 (33%), Positives = 214/376 (56%), Gaps = 53/376 (14%) Query: 23 RYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLM-KLVNHK 81 +Y ++ +G GA GIV + D T + VA+KK+ FQN T A+R +RE ++ +L H+ Sbjct: 10 KYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIFDAFQNSTDAQRTFREIMILTELSGHE 69 Query: 82 NIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMD-LDHDRMSYLLYQMLCGIKHL 140 NI+ LLN + +DVYLV + M+ +L VI+ + L+ Y++YQ++ IK+L Sbjct: 70 NIVNLLNVLRADND----RDVYLVFDYMETDLHAVIRANILEPVHKQYVVYQLIKVIKYL 125 Query: 141 HSAGIIHRDLKPSNIVVKADCTLKILDFGLART-----------------AGTTF----- 178 HS G++HRD+KPSNI++ A+C +K+ DFGL+R+ F Sbjct: 126 HSGGLLHRDMKPSNILLNAECHVKVADFGLSRSFVNIRRVTNNIPLSINENTENFDDDQP 185 Query: 179 MMTPYVVTRYYRAPEVILG-MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIE 237 ++T YV TR+YRAPE++LG YT+ +D+WS+GCI+GE++ G +FPG+ ++Q +II Sbjct: 186 ILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGKPIFPGSSTMNQLERIIG 245 Query: 238 QLGTPSPSFMQRLQP--------TVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRK 289 + PS ++ +Q +++ VE R F + + + L + + + Sbjct: 246 VIDFPSNEDVESIQSPFAKTMIESLKEKVEIRQSNKRDIFTK-WKNLLLKINPKADCNEE 304 Query: 290 ASDARNLLSKMLVIDPEQRISVDEALKHEYINVWYDAEEVDAPAPEP-YDHSV-----DE 343 A D LL K+L +P +RIS ++ALKH +++++++ P EP DH + D Sbjct: 305 ALD---LLDKLLQFNPNKRISANDALKHPFVSIFHN------PNEEPNCDHIITIPINDN 355 Query: 344 REHTVEQWKELIYEEV 359 +H+++ ++ L+Y E+ Sbjct: 356 VKHSIDDYRNLVYSEI 371 >4QNY-A nrPDB Length = 354 Score = 198 bits (504), Expect = 3e-51, Method: Compositional matrix adjust. Identities = 124/356 (34%), Positives = 200/356 (56%), Gaps = 29/356 (8%) Query: 20 IHSRYINLRPIGSGAQGIVCAAYDTITQQN-VAIKKLSRP-FQNVTHAKRAYREFKLMKL 77 + RY+ R IG+G+ G+V A DT + VA+K++++ F+ V AKR RE KL+ Sbjct: 18 LDDRYLLERIIGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFEEVILAKRILREIKLLAH 77 Query: 78 VNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQ--MDLDHDRMSYLLYQMLC 135 N NIIGL N TP+ + E F Y+VM++M+ +L QV++ +L + + +YQ L Sbjct: 78 FNDDNIIGLRNILTPE-DPENFDHFYIVMDIMETDLKQVLRSGQELTEAHIQFFIYQALR 136 Query: 136 GIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTF-MMTPYVVTRYYRAPEV 194 + +HSAG+IHRD+ P+NI+V +C LKI DFGLA+ MT YV R+YRAPE+ Sbjct: 137 ALHIIHSAGVIHRDITPANILVNTNCDLKICDFGLAKEENDQGEYMTDYVTMRWYRAPEL 196 Query: 195 IL-GMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRL-QP 252 ++ Y+ +D+W +GCI+GE++ LF G D ++Q +KI++ +GTPS + + Sbjct: 197 VMEDKDYSAQIDVWGIGCILGELLGSRPLFQGKDRVNQLDKIVDVIGTPSEEDINSVGSS 256 Query: 253 TVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVD 312 + Y++ + + + +P + +A +LL MLV +P++RI+V Sbjct: 257 AAQKYLKKKSHRPQADWRQRYPTA-------------SPEALDLLRHMLVFNPKRRITVL 303 Query: 313 EALKHEYINVWYDAEEVDAPAPEPYD-HSVDEREH-TVEQWKELIYEEVMDYEAHN 366 +A++H ++ +D DA Y DE E T+ K IYEE + + HN Sbjct: 304 QAMRHPFLEQLHD----DADDNLSYALFRFDENEQKTIVDVKRAIYEESVKF--HN 353 >3RP9-A nrPDB Length = 458 Score = 196 bits (497), Expect = 2e-50, Method: Compositional matrix adjust. Identities = 120/368 (32%), Positives = 191/368 (51%), Gaps = 77/368 (20%) Query: 16 TNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLM 75 +++ I RY IG+G+ G VC AYD + ++ VAIKK+ R F+++ KR RE ++ Sbjct: 47 SDWQIPDRYEIRHLIGTGSYGHVCEAYDKLEKRVVAIKKILRVFEDLIDCKRILREIAIL 106 Query: 76 KLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMD--LDHDRMSYLLYQM 133 +NH +++ +L+ P +++E+F ++Y+V+E+ D++ ++ + L + LLY + Sbjct: 107 NRLNHDHVVKVLDIVIP-KDVEKFDELYVVLEIADSDFKKLFRTPVYLTELHIKTLLYNL 165 Query: 134 LCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAG------------------ 175 L G+K++HSAGI+HRDLKP+N +V DC++K+ DFGLART Sbjct: 166 LVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFGLARTVDYPENGNSQLPISPREDDM 225 Query: 176 --TTF--------MMTPYVVTRYYRAPEVI-LGMGYTENVDIWSVGCIMGEMIR------ 218 TF +T +VVTR+YRAPE+I L YTE +D+WS+GCI E++ Sbjct: 226 NLVTFPHTKNLKRQLTGHVVTRWYRAPELILLQENYTEAIDVWSIGCIFAELLNMIKENV 285 Query: 219 -----GGVLFPGTDHI--------------------DQWNKIIEQLGTPSPSFMQRLQPT 253 G LFPG+ DQ N I LGTPS ++ L+ Sbjct: 286 AYHADRGPLFPGSSCFPLSPDQKAGNDFKFHTRGNRDQLNVIFNILGTPSEEDIEALEKE 345 Query: 254 -VRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVD 312 + Y+ P+ G FP ++DA +LL +MLV +P +RI+++ Sbjct: 346 DAKRYIRIFPKREGTDLAERFPAS-------------SADAIHLLKRMLVFNPNKRITIN 392 Query: 313 EALKHEYI 320 E L H + Sbjct: 393 ECLAHPFF 400 >3N9X-A nrPDB Length = 432 Score = 177 bits (448), Expect = 8e-45, Method: Compositional matrix adjust. Identities = 118/366 (32%), Positives = 186/366 (50%), Gaps = 77/366 (21%) Query: 14 GDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFK 73 G N + YI IG G+ G V AYD T++NVAIKK++R F+++ KR RE Sbjct: 18 GIKNVHVPDNYIIKHLIGRGSYGYVYLAYDKNTEKNVAIKKVNRMFEDLIDCKRILREIT 77 Query: 74 LMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQ--MDLDHDRMSYLLY 131 ++ + II L + P +L +F ++Y+V+E+ D++L ++ + + L + + +LY Sbjct: 78 ILNRLKSDYIIRLYDLIIPD-DLLKFDELYIVLEIADSDLKKLFKTPIFLTEEHIKTILY 136 Query: 132 QMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGT--------------- 176 +L G +H +GIIHRDLKP+N ++ DC++K+ DFGLART + Sbjct: 137 NLLLGENFIHESGIIHRDLKPANCLLNQDCSVKVCDFGLARTINSEKDTNIVNDLEENEE 196 Query: 177 --------TFMMTPYVVTRYYRAPEVILGM-GYTENVDIWSVGCIMGE---MIRGGV--- 221 +T +VVTR+YRAPE+IL YT+++DIWS GCI E M++ + Sbjct: 197 PGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAELLNMLQSHINDP 256 Query: 222 -----LFPGTDHI-----------------DQWNKIIEQLGTPSPSFMQRL-QPTVRNYV 258 LFPG+ DQ N I +GTP+ ++ + +P V Y+ Sbjct: 257 TNRFPLFPGSSCFPLSPDRNSKKVHEKSNRDQLNIIFNIIGTPTEDDLKNINKPEVIKYI 316 Query: 259 ENRPRYTGYSFDRLFPDGLFPNDNNQNSRRK----ASDARNLLSKMLVIDPEQRISVDEA 314 + LFP+ N ++K + D NLL ML +P +RI++D+A Sbjct: 317 K-----------------LFPHRKPINLKQKYPSISDDGINLLESMLKFNPNKRITIDQA 359 Query: 315 LKHEYI 320 L H Y+ Sbjct: 360 LDHPYL 365 >2I6L-A nrPDB Length = 320 Score = 170 bits (431), Expect = 8e-43, Method: Compositional matrix adjust. Identities = 105/324 (32%), Positives = 172/324 (53%), Gaps = 34/324 (10%) Query: 17 NFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKK--LSRPFQNVTHAKRAYREFKL 74 F + SRY++L+P+G G G+V +A D + VAIKK L+ P Q+V HA RE K+ Sbjct: 6 GFDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDP-QSVKHA---LREIKI 61 Query: 75 MKLVNHKNIIGLLNAFTPQRN--------LEEFQDVYLVMELMDANLCQVI-QMDLDHDR 125 ++ ++H NI+ + P + L E VY+V E M+ +L V+ Q L + Sbjct: 62 IRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEH 121 Query: 126 MSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKA-DCTLKILDFGLARTAGTTFM----M 180 +YQ+L G+K++HSA ++HRDLKP+N+ + D LKI DFGLAR + + Sbjct: 122 ARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHL 181 Query: 181 TPYVVTRYYRAPEVILGMG-YTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQL 239 + +VT++YR+P ++L YT+ +D+W+ GCI EM+ G LF G ++Q I+E + Sbjct: 182 SEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESI 241 Query: 240 GTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSK 299 Q L + Y+ N +L P G+ + +A + L + Sbjct: 242 PVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLP-GI------------SREAVDFLEQ 288 Query: 300 MLVIDPEQRISVDEALKHEYINVW 323 +L P R++ +EAL H Y++++ Sbjct: 289 ILTFSPMDRLTAEEALSHPYMSIY 312 >3NIZ-A nrPDB Length = 311 Score = 168 bits (426), Expect = 3e-42, Method: Compositional matrix adjust. Identities = 110/304 (36%), Positives = 160/304 (52%), Gaps = 25/304 (8%) Query: 23 RYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKN 82 +Y L +G G G+V A D+ + VA+K++ ++ A RE L+K ++H N Sbjct: 22 KYQKLEKVGEGTYGVVYKAKDS-QGRIVALKRIRLDAEDEGIPSTAIREISLLKELHHPN 80 Query: 83 IIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVI---QMDLDHDRMSYLLYQMLCGIKH 139 I+ L++ +R L LV E M+ +L +V+ + L ++ LYQ+L G+ H Sbjct: 81 IVSLIDVIHSERCLT------LVFEFMEKDLKKVLDENKTGLQDSQIKIYLYQLLRGVAH 134 Query: 140 LHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTF-MMTPYVVTRYYRAPEVILG- 197 H I+HRDLKP N+++ +D LK+ DFGLAR G T VVT +YRAP+V++G Sbjct: 135 CHQHRILHRDLKPQNLLINSDGALKLADFGLARAFGIPVRSYTHEVVTLWYRAPDVLMGS 194 Query: 198 MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNY 257 Y+ +VDIWS+GCI EMI G LFPG DQ KI LGTP+P R P V+ Sbjct: 195 KKYSTSVDIWSIGCIFAEMITGKPLFPGVTDDDQLPKIFSILGTPNP----REWPQVQEL 250 Query: 258 VENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKH 317 + R T F++ + P + +LLS ML DP +RIS +A+ H Sbjct: 251 PLWKQR-TFQVFEKKPWSSIIPG--------FCQEGIDLLSNMLCFDPNKRISARDAMNH 301 Query: 318 EYIN 321 Y Sbjct: 302 PYFK 305 >2BPM-A nrPDB Length = 309 Score = 168 bits (425), Expect = 4e-42, Method: Compositional matrix adjust. Identities = 115/327 (35%), Positives = 163/327 (49%), Gaps = 44/327 (13%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNA 89 IG G G+V A + +T + VA+KK+ + A RE L+K +NH NI+ LL+ Sbjct: 15 IGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDV 74 Query: 90 FTPQRNLEEFQDVYLVMEL--------MDANLCQVIQMDLDHDRMSYLLYQMLCGIKHLH 141 + L YLV E MDA+ I + L + L+Q+L G+ H Sbjct: 75 IHTENKL------YLVFEFLHQDLKKFMDASALTGIPLPL----IKSYLFQLLQGLAFCH 124 Query: 142 SAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTF-MMTPYVVTRYYRAPEVILGMG- 199 S ++HRDLKP N+++ + +K+ DFGLAR G T VVT +YRAPE++LG Sbjct: 125 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKY 184 Query: 200 YTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVE 259 Y+ VDIWS+GCI EM+ LFPG IDQ +I LGTP + ++ +Y Sbjct: 185 YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVT-SMPDYKP 243 Query: 260 NRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEY 319 + P++ F ++ P P D D R+LLS+ML DP +RIS AL H + Sbjct: 244 SFPKWARQDFSKVVP----PLDE---------DGRSLLSQMLHYDPNKRISAKAALAHPF 290 Query: 320 INVWYDAEEVDAPAPEPYDHSVDEREH 346 ++V P P H ER H Sbjct: 291 F------QDVTKPVP----HLRLERPH 307 >3PG1-A nrPDB Length = 362 Score = 168 bits (425), Expect = 4e-42, Method: Compositional matrix adjust. Identities = 112/327 (34%), Positives = 166/327 (50%), Gaps = 40/327 (12%) Query: 19 TIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHA------------K 66 + S Y R I SG+ G VCA D+ VAIK R F V+ K Sbjct: 19 AMQSPYTVQRFISSGSYGAVCAGVDS-EGIPVAIK---RVFNTVSDGRTVNILSDSFLCK 74 Query: 67 RAYREFKLMKLVNHKNIIGLLNAFTPQRNLEE--FQDVYLVMELMDANLCQVI---QMDL 121 R RE +L+ +H NI+GL + F + EE +YLV ELM +L QVI ++ + Sbjct: 75 RVLREIRLLNHFHHPNILGLRDIFV---HFEEPAMHKLYLVTELMRTDLAQVIHDQRIVI 131 Query: 122 DHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMT 181 + Y +Y +L G+ LH AG++HRDL P NI++ + + I DF LAR T Sbjct: 132 SPQHIQYFMYHILLGLHVLHEAGVVHRDLHPGNILLADNNDITICDFNLAREDTADANKT 191 Query: 182 PYVVTRYYRAPEVILGM-GYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLG 240 YV R+YRAPE+++ G+T+ VD+WS GC+M EM LF G+ +Q NKI+E +G Sbjct: 192 HYVTHRWYRAPELVMQFKGFTKLVDMWSAGCVMAEMFNRKALFRGSTFYNQLNKIVEVVG 251 Query: 241 TPS-PSFMQRLQPTVRNYVENR-PRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLS 298 TP + P+ R+Y+ N ++ + P A +L++ Sbjct: 252 TPKIEDVVMFSSPSARDYLRNSLSNVPARAWTAVVPTA-------------DPVALDLIA 298 Query: 299 KMLVIDPEQRISVDEALKHEYINVWYD 325 KML +P++RIS ++AL+H Y +D Sbjct: 299 KMLEFNPQRRISTEQALRHPYFESLFD 325 >3NIE-A nrPDB Length = 429 Score = 163 bits (412), Expect = 1e-40, Method: Compositional matrix adjust. Identities = 114/351 (32%), Positives = 180/351 (51%), Gaps = 76/351 (21%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNA 89 IG G+ G V AYD +NVAIKK++R F+++ KR RE ++ + II L + Sbjct: 36 IGRGSYGYVYLAYDKNANKNVAIKKVNRMFEDLIDCKRILREITILNRLKSDYIIRLHDL 95 Query: 90 FTPQRNLEEFQDVYLVMELMDANLCQVIQ--MDLDHDRMSYLLYQMLCGIKHLHSAGIIH 147 P+ +L +F ++Y+V+E+ D++L ++ + + L + +LY +L G K +H +GIIH Sbjct: 96 IIPE-DLLKFDELYIVLEIADSDLKKLFKTPIFLTEQHVKTILYNLLLGEKFIHESGIIH 154 Query: 148 RDLKPSNIVVKADCTLKILDFGLARTAGT--------------------------TFMMT 181 RDLKP+N ++ DC++KI DFGLART + +T Sbjct: 155 RDLKPANCLLNQDCSVKICDFGLARTINSDKDIHIVNDLEEKEENEEPGPHNKNLKKQLT 214 Query: 182 PYVVTRYYRAPEVILGM-GYTENVDIWSVGCIMGE---MIRGGV--------LFPGT--- 226 +VVTR+YRAPE+IL YT ++DIWS GCI E M++ + LFPG+ Sbjct: 215 SHVVTRWYRAPELILLQENYTNSIDIWSTGCIFAELLNMMKSHINNPTNRFPLFPGSSCF 274 Query: 227 ----DH----------IDQWNKIIEQLGTPSPSFMQRL-QPTVRNYVENRPRYTGYSFDR 271 DH DQ N I +GTP ++ + + V Y+ + Sbjct: 275 PLSPDHNSKKVHEKSNRDQLNIIFNVIGTPPEEDLKCITKQEVIKYI------------K 322 Query: 272 LFP--DGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEYI 320 LFP DG+ D ++ + + +LL ML + ++RI++D+AL H Y+ Sbjct: 323 LFPTRDGI---DLSKKYSSISKEGIDLLESMLRFNAQKRITIDKALSHPYL 370 >4E7W-A nrPDB Length = 394 Score = 158 bits (400), Expect = 3e-39, Method: Compositional matrix adjust. Identities = 105/313 (33%), Positives = 167/313 (53%), Gaps = 43/313 (13%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKL--SRPFQNVTHAKRAYREFKLMKLVNHK 81 Y N + IG+G+ G+V A + VAIKK+ + F+N RE ++M++V H Sbjct: 42 YTNCKVIGNGSFGVVFQA-KLVESDEVAIKKVLQDKRFKN--------RELQIMRIVKHP 92 Query: 82 NIIGLLNAFTPQRNLEEFQDVYLVMELMD----------ANLCQVIQMDLDHDRMSYLLY 131 N++ L F + ++ + LV+E + A L Q + M L + +Y Sbjct: 93 NVVDLKAFFYSNGDKKDEVFLNLVLEYVPETVYRASRHYAKLKQTMPMLL----IKLYMY 148 Query: 132 QMLCGIKHLHSAGIIHRDLKPSNIVVKADC-TLKILDFGLARTAGTTFMMTPYVVTRYYR 190 Q+L + ++HS GI HRD+KP N+++ LK++DFG A+ Y+ +RYYR Sbjct: 149 QLLRSLAYIHSIGICHRDIKPQNLLLDPPSGVLKLIDFGSAKILIAGEPNVSYICSRYYR 208 Query: 191 APEVILGM-GYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQR 249 APE+I G YT N+DIWS GC+M E+++G LFPG IDQ +II+ LGTPS ++ Sbjct: 209 APELIFGATNYTTNIDIWSTGCVMAELMQGQPLFPGESGIDQLVEIIKVLGTPSREQIKT 268 Query: 250 LQPTVRNYVENR-PRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQR 308 + P NY+E++ P+ + F ++F R DA +L+S++L P R Sbjct: 269 MNP---NYMEHKFPQIRPHPFSKVF------------RPRTPPDAIDLISRLLEYTPSAR 313 Query: 309 ISVDEALKHEYIN 321 ++ EAL H + + Sbjct: 314 LTAIEALCHPFFD 326 >1V0B-A nrPDB Length = 288 Score = 154 bits (389), Expect = 6e-38, Method: Compositional matrix adjust. Identities = 102/303 (33%), Positives = 150/303 (49%), Gaps = 26/303 (8%) Query: 23 RYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKN 82 +Y L IG G G+V A + + A+KK+ ++ RE ++K + H N Sbjct: 3 KYHGLEKIGEGTYGVVYKAQNNYGE-TFALKKIRLEKEDEGIPSTTIREISILKELKHSN 61 Query: 83 IIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQM---DLDHDRMSYLLYQMLCGIKH 139 I+ L + ++ L LV E +D +L +++ + L+ L Q+L GI + Sbjct: 62 IVKLYDVIHTKKRL------VLVFEHLDQDLKKLLDVCEGGLESVTAKSFLLQLLNGIAY 115 Query: 140 LHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTF-MMTPYVVTRYYRAPEVILG- 197 H ++HRDLKP N+++ + LKI DFGLAR G T VVT +YRAP+V++G Sbjct: 116 CHDRRVLHRDLKPQNLLINREGELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVLMGS 175 Query: 198 MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNY 257 Y+ +DIWSVGCI EM+ G LFPG DQ +I LGTP+ + P V Sbjct: 176 KKYSTTIDIWSVGCIFAEMVNGAPLFPGVSEADQLMRIFRILGTPN----SKNWPNVTEL 231 Query: 258 VENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKH 317 + P +T Y P + +LLSKML +DP QRI+ +AL+H Sbjct: 232 PKYDPNFTVYE----------PLPWESFLKGLDESGIDLLSKMLKLDPNQRITAKQALEH 281 Query: 318 EYI 320 Y Sbjct: 282 AYF 284 >6GU6-A nrPDB Length = 302 Score = 153 bits (387), Expect = 1e-37, Method: Compositional matrix adjust. Identities = 102/305 (33%), Positives = 150/305 (49%), Gaps = 27/305 (8%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNI 83 Y + IG G G+V T Q VA+KK+ + A RE L+K + H NI Sbjct: 9 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNI 68 Query: 84 IGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQ-----MDLDHDRMSYLLYQMLCGIK 138 + L Q L + +YL+ E + +L + + +D + LYQ+L GI Sbjct: 69 VSL------QDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIV 122 Query: 139 HLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTF-MMTPYVVTRYYRAPEVILG 197 HS ++HRDLKP N+++ T+K+ DFGLAR G + T VVT +YR+PEV+LG Sbjct: 123 FCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLG 182 Query: 198 MG-YTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRN 256 Y+ VDIWS+G I E+ LF G IDQ +I LGTP+ ++ ++++ Sbjct: 183 SARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVE-SLQD 241 Query: 257 YVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALK 316 Y P++ P + + + +LLSKML+ DP +RIS AL Sbjct: 242 YKNTFPKWK-------------PGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALN 288 Query: 317 HEYIN 321 H Y N Sbjct: 289 HPYFN 293 >3EB0-A nrPDB Length = 383 Score = 153 bits (386), Expect = 1e-37, Method: Compositional matrix adjust. Identities = 109/366 (29%), Positives = 184/366 (50%), Gaps = 62/366 (16%) Query: 19 TIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLV 78 T +Y + +G+G+ GIVC +D + + A+KK+ + + RE +MK++ Sbjct: 4 TSSKKYSLGKTLGTGSFGIVCEVFDIESGKRFALKKV------LQDPRYKNRELDIMKVL 57 Query: 79 NHKNIIGLLNAF---------TPQ----------RN-----------LEEFQDVYL--VM 106 +H NII L++ F PQ +N + Q+ YL +M Sbjct: 58 DHVNIIKLVDYFYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNVIM 117 Query: 107 ELMDANLCQVIQMDLDHDR------MSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKA- 159 E + L +V++ + R +S +YQ+ + +HS GI HRD+KP N++V + Sbjct: 118 EYVPDTLHKVLKSFIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLLVNSK 177 Query: 160 DCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMG-YTENVDIWSVGCIMGEMIR 218 D TLK+ DFG A+ + Y+ +R+YRAPE++LG YT ++D+WS+GC+ GE+I Sbjct: 178 DNTLKLCDFGSAKKLIPSEPSVAYICSRFYRAPELMLGATEYTPSIDLWSIGCVFGELIL 237 Query: 219 GGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENR-PRYTGYSFDRLFPDGL 277 G LF G IDQ +II+ +GTP+ M R+ P +Y E R P + ++ P+G Sbjct: 238 GKPLFSGETSIDQLVRIIQIMGTPTKEQMIRMNP---HYTEVRFPTLKAKDWRKILPEG- 293 Query: 278 FPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEYINVWYDAEEVDAPAPEPY 337 S A +LL ++L +P+ RI+ EA+ H + + ++ E + + Sbjct: 294 -----------TPSLAIDLLEQILRYEPDLRINPYEAMAHPFFDHLRNSYESEVKNNSNF 342 Query: 338 DHSVDE 343 H V++ Sbjct: 343 PHGVNQ 348 >3ZDU-A nrPDB Length = 325 Score = 150 bits (378), Expect = 1e-36, Method: Compositional matrix adjust. Identities = 105/306 (34%), Positives = 154/306 (50%), Gaps = 34/306 (11%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKL-SRPFQNVTHAKRAYREFKLMKLVNHKN 82 Y L +G G+ G V T Q VAIK RP Q+V K A RE K +K +H+N Sbjct: 5 YETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVN--KIAMREIKFLKQFHHEN 62 Query: 83 IIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQM---DLDHDRMSYLLYQMLCGIKH 139 ++ L+ F ++ ++LV E +D + +Q L+ R+ L+Q+L I + Sbjct: 63 LVNLIEVFRQKKK------IHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDY 116 Query: 140 LHSAGIIHRDLKPSNIVVKADCTLKILDFGLART-AGTTFMMTPYVVTRYYRAPEVILG- 197 LHS IIHRD+KP NI+V K+ DFG ART A + V TR+YRAPE++L Sbjct: 117 LHSNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYDDEVATRWYRAPELVLKD 176 Query: 198 MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNY 257 Y + VDIW++GC++ EM G P + +D +KI+ ++G L P ++N Sbjct: 177 TSYGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGN--------LSPHLQNI 228 Query: 258 VENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKM----LVIDPEQRISVDE 313 P + G + P P +N+R+K LL+ + L IDP RIS + Sbjct: 229 FSKSPIFAGV----VLPQVQHP----KNARKKYPKLNGLLADIVHACLQIDPADRISSSD 280 Query: 314 ALKHEY 319 L HEY Sbjct: 281 LLHHEY 286 >2W96-B nrPDB Length = 306 Score = 149 bits (375), Expect = 3e-36, Method: Compositional matrix adjust. Identities = 105/311 (33%), Positives = 147/311 (47%), Gaps = 32/311 (10%) Query: 22 SRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVN-- 79 SRY + IG GA G V A D + VA+K + P RE L++ + Sbjct: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGLPISTVREVALLRRLEAF 63 Query: 80 -HKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQM----DLDHDRMSYLLYQML 134 H N++ L++ R E + V LV E +D +L + L + + L+ Q L Sbjct: 64 EHPNVVRLMDVCATSRTDREIK-VTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFL 122 Query: 135 CGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEV 194 G+ LH+ I+HRDLKP NI+V + T+K+ DFGLAR + P VVT +YRAPEV Sbjct: 123 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALDPVVVTLWYRAPEV 182 Query: 195 ILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTV 254 +L Y VD+WSVGCI EM R LF G DQ KI + +G P Sbjct: 183 LLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPP----------- 231 Query: 255 RNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASD----ARNLLSKMLVIDPEQRIS 310 ++ PR D P G FP + + + LL +ML +P +RIS Sbjct: 232 ---EDDWPR------DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRIS 282 Query: 311 VDEALKHEYIN 321 AL+H Y++ Sbjct: 283 AFRALQHSYLH 293 >4AU8-A nrPDB Length = 296 Score = 147 bits (372), Expect = 5e-36, Method: Compositional matrix adjust. Identities = 102/305 (33%), Positives = 153/305 (50%), Gaps = 26/305 (8%) Query: 23 RYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKN 82 +Y L IG G G V A + T + VA+K++ + A RE L+K + HKN Sbjct: 7 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 66 Query: 83 IIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQM---DLDHDRMSYLLYQMLCGIKH 139 I+ L + + L LV E D +L + DLD + + L+Q+L G+ Sbjct: 67 IVRLHDVLHSDKKLT------LVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGF 120 Query: 140 LHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTF-MMTPYVVTRYYRAPEVILGM 198 HS ++HRDLKP N+++ + LK+ DFGLAR G + VVT +YR P+V+ G Sbjct: 121 CHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGA 180 Query: 199 G-YTENVDIWSVGCIMGEMIRGG-VLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRN 256 Y+ ++D+WS GCI E+ G LFPG D DQ +I LGTP+ + P++ Sbjct: 181 KLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPT----EEQWPSMTK 236 Query: 257 YVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALK 316 + +P Y Y + + P N + R+LL +L +P QRIS +EAL+ Sbjct: 237 LPDYKP-YPMYPATTSLVN-VVPKLN--------ATGRDLLQNLLKCNPVQRISAEEALQ 286 Query: 317 HEYIN 321 H Y + Sbjct: 287 HPYFS 291 >4BBM-A nrPDB Length = 331 Score = 147 bits (371), Expect = 7e-36, Method: Compositional matrix adjust. Identities = 105/322 (32%), Positives = 159/322 (49%), Gaps = 31/322 (9%) Query: 11 VEVGDTNFTIHS--RYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRA 68 V++G N S +Y NL +G G+ G+V + T + VAIKK + K A Sbjct: 12 VDLGTENLYFQSMEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIA 71 Query: 69 YREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQM---DLDHDR 125 RE KL+K + H+N++ LL ++ YLV E +D + +++ LD+ Sbjct: 72 MREIKLLKQLRHENLVNLLEVCKKKKRW------YLVFEFVDHTILDDLELFPNGLDYQV 125 Query: 126 MSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLART-AGTTFMMTPYV 184 + L+Q++ GI HS IIHRD+KP NI+V +K+ DFG ART A + V Sbjct: 126 VQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYDDEV 185 Query: 185 VTRYYRAPEVILG-MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPS 243 TR+YRAPE+++G + Y + VD+W++GC++ EM G LFPG IDQ I+ LG Sbjct: 186 ATRWYRAPELLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGN-- 243 Query: 244 PSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRR--KASDAR-NLLSKM 300 L P + P + G + + RR K S+ +L K Sbjct: 244 ------LIPRHQELFNKNPVFAGVRLPEI-------KEREPLERRYPKLSEVVIDLAKKC 290 Query: 301 LVIDPEQRISVDEALKHEYINV 322 L IDP++R E L H++ + Sbjct: 291 LHIDPDKRPFCAELLHHDFFQM 312 >4BGQ-A nrPDB Length = 304 Score = 145 bits (367), Expect = 2e-35, Method: Compositional matrix adjust. Identities = 95/299 (31%), Positives = 150/299 (50%), Gaps = 34/299 (11%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNA 89 +G GA G+V T + VAIKK +N + RE K+++ + +NI+ L A Sbjct: 20 VGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIVELKEA 79 Query: 90 FTPQRNLEEFQDVYLVMELMDANLCQVIQM---DLDHDRMSYLLYQMLCGIKHLHSAGII 146 F + L YLV E ++ N+ ++++ + +++ +YQ++ I H I+ Sbjct: 80 FRRRGKL------YLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIV 133 Query: 147 HRDLKPSNIVVKADCTLKILDFGLAR--TAGTTFMMTPYVVTRYYRAPEVILGMGYTENV 204 HRD+KP N+++ + LK+ DFG AR + G V TR+YR+PE++LG Y ++V Sbjct: 134 HRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYDEEVATRWYRSPELLLGAPYGKSV 193 Query: 205 DIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENRPRY 264 D+WSVGCI+GE+ G LFPG IDQ I + LG P PS +L + PR+ Sbjct: 194 DMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLG-PLPSEQMKL-------FYSNPRF 245 Query: 265 TGYSFDRLFPDGLFPNDNNQNSRRKA------SDARNLLSKMLVIDPEQRISVDEALKH 317 G FP N+ S + S +L+ +L +DP R ++ L H Sbjct: 246 HGLR---------FPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNH 295 >1UA2-A nrPDB Length = 346 Score = 144 bits (364), Expect = 4e-35, Method: Compositional matrix adjust. Identities = 102/322 (31%), Positives = 163/322 (50%), Gaps = 37/322 (11%) Query: 23 RYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTH---AKRAYREFKLMKLVN 79 RY L +G G V A D T Q VAIKK+ ++ + A RE KL++ ++ Sbjct: 11 RYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS 70 Query: 80 HKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQ---MDLDHDRMSYLLYQMLCG 136 H NIIGLL+AF + N + LV + M+ +L +I+ + L + + L G Sbjct: 71 HPNIIGLLDAFGHKSN------ISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQG 124 Query: 137 IKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGT-TFMMTPYVVTRYYRAPEVI 195 +++LH I+HRDLKP+N+++ + LK+ DFGLA++ G+ T VVTR+YRAPE++ Sbjct: 125 LEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELL 184 Query: 196 LGMG-YTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTV 254 G Y VD+W+VGCI+ E++ PG +DQ +I E LGTP+ + ++ Sbjct: 185 FGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMC-SL 243 Query: 255 RNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEA 314 +YV + + G +F D +L+ + + +P RI+ +A Sbjct: 244 PDYVTFK-SFPGIPLHHIF-------------SAAGDDLLDLIQGLFLFNPCARITATQA 289 Query: 315 LKHEYINVWYDAEEVDAPAPEP 336 LK +Y + + P P P Sbjct: 290 LKMKYFS--------NRPGPTP 303 >3GC0-A nrPDB Length = 329 Score = 144 bits (362), Expect = 7e-35, Method: Compositional matrix adjust. Identities = 100/308 (32%), Positives = 155/308 (50%), Gaps = 28/308 (9%) Query: 23 RYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKN 82 RY + +G G G V A DT+T + VAIK++ + A RE L+K + H+N Sbjct: 35 RYRRITKLGEGTYGEVYKAIDTVTNETVAIKRIRLEHEEEGVPGTAIREVSLLKELQHRN 94 Query: 83 IIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQM--DLDHDRMSYLLYQMLCGIKHL 140 II L + L +L+ E + +L + + D+ + LYQ++ G+ Sbjct: 95 IIELKSVIHHNHRL------HLIFEYAENDLKKYMDKNPDVSMRVIKSFLYQLINGVNFC 148 Query: 141 HSAGIIHRDLKPSNIVVK-ADCT----LKILDFGLARTAGTTF-MMTPYVVTRYYRAPEV 194 HS +HRDLKP N+++ +D + LKI DFGLAR G T ++T +YR PE+ Sbjct: 149 HSRRCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQFTHEIITLWYRPPEI 208 Query: 195 ILGM-GYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPT 253 +LG Y+ +VDIWS+ CI EM+ LFPG IDQ KI E LG P + + Sbjct: 209 LLGSRHYSTSVDIWSIACIWAEMLMKTPLFPGDSEIDQLFKIFEVLGLPDDTTWPGVT-A 267 Query: 254 VRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDE 313 + ++ ++ P++ G + R+ + +LL+ ML +DP +RIS Sbjct: 268 LPDWKQSFPKFRGKTLKRVL------------GALLDDEGLDLLTAMLEMDPVKRISAKN 315 Query: 314 ALKHEYIN 321 AL+H Y + Sbjct: 316 ALEHPYFS 323 >1G3N-A nrPDB Length = 326 Score = 140 bits (354), Expect = 7e-34, Method: Compositional matrix adjust. Identities = 100/311 (32%), Positives = 150/311 (48%), Gaps = 33/311 (10%) Query: 23 RYINLRPIGSGAQGIVCAAYDTITQ-QNVAIKKLSRPFQNVTHAKRAYREFKLMK---LV 78 +Y + IG GA G V A D + VA+K++ RE +++ Sbjct: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETF 71 Query: 79 NHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLC----QVIQMDLDHDRMSYLLYQML 134 H N++ L + T R E + + LV E +D +L +V + + + + +++Q+L Sbjct: 72 EHPNVVRLFDVCTVSRTDRETK-LTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130 Query: 135 CGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEV 194 G+ LHS ++HRDLKP NI+V + +K+ DFGLAR +T VVT +YRAPEV Sbjct: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEV 190 Query: 195 ILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTV 254 +L Y VD+WSVGCI EM R LF G+ +DQ KI++ +G P Sbjct: 191 LLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGE---------- 240 Query: 255 RNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASD----ARNLLSKMLVIDPEQRIS 310 E+ PR D P F + + Q + +D ++LL K L +P +RIS Sbjct: 241 ----EDWPR------DVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRIS 290 Query: 311 VDEALKHEYIN 321 AL H Y Sbjct: 291 AYSALSHPYFQ 301 >4KRC-A nrPDB Length = 317 Score = 140 bits (352), Expect = 1e-33, Method: Compositional matrix adjust. Identities = 99/315 (31%), Positives = 154/315 (48%), Gaps = 30/315 (9%) Query: 22 SRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHK 81 S++ L +G+G V + T VA+K++ + T + A RE LMK + H+ Sbjct: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPST-AIREISLMKELKHE 63 Query: 82 NIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQM--------DLDHDRMSYLLYQM 133 NI+ L + + L LV E MD +L + + L+ + + Y +Q+ Sbjct: 64 NIVRLYDVIHTENKLT------LVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQL 117 Query: 134 LCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTF-MMTPYVVTRYYRAP 192 L G+ H I+HRDLKP N+++ LK+ DFGLAR G + VVT +YRAP Sbjct: 118 LQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAP 177 Query: 193 EVILGM-GYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQ 251 +V++G Y+ ++DIWS GCI+ EMI G LFPGT+ +Q I + +GTP+ S + Sbjct: 178 DVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVT 237 Query: 252 --PTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRI 309 P ++ RP L P P D N + L +L ++P+ R+ Sbjct: 238 KLPKYNPNIQQRPPRDLRQV--LQPHTKEPLDGN---------LMDFLHGLLQLNPDMRL 286 Query: 310 SVDEALKHEYINVWY 324 S +AL H + +Y Sbjct: 287 SAKQALHHPWFAEYY 301 >5AIR-A nrPDB Length = 430 Score = 137 bits (344), Expect = 1e-32, Method: Compositional matrix adjust. Identities = 95/315 (30%), Positives = 163/315 (51%), Gaps = 38/315 (12%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKL--SRPFQNVTHAKRAYREFKLMKLVNHK 81 Y + + IG+G+ G+V A + + VAIKK+ + F+N RE ++M+ ++H Sbjct: 66 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN--------RELQIMRKLDHC 117 Query: 82 NIIGLLNAFTPQRNLEEFQDVYL--VMELMDANLCQVI------QMDLDHDRMSYLLYQM 133 NI+ L F + E+ +VYL V++ + + +V + L + +YQ+ Sbjct: 118 NIVRLRYFF--YSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQL 175 Query: 134 LCGIKHLHSAGIIHRDLKPSNIVVKAD-CTLKILDFGLARTAGTTFMMTPYVVTRYYRAP 192 + ++HS GI HRD+KP N+++ D LK+ DFG A+ Y+ +RYYRAP Sbjct: 176 FRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAP 235 Query: 193 EVILGMG-YTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQ 251 E+I G YT ++D+WS GC++ E++ G +FPG +DQ +II+ LGTP+ ++ + Sbjct: 236 ELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMN 295 Query: 252 PTVRNYVENR-PRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRIS 310 P NY E + P+ + + ++F R +A L S++L P R++ Sbjct: 296 P---NYTEFKFPQIKAHPWTKVF------------RPRTPPEAIALCSRLLEYTPTARLT 340 Query: 311 VDEALKHEYINVWYD 325 EA H + + D Sbjct: 341 PLEACAHSFFDELRD 355 >3E3P-A nrPDB Length = 360 Score = 134 bits (338), Expect = 5e-32, Method: Compositional matrix adjust. Identities = 101/310 (32%), Positives = 157/310 (50%), Gaps = 27/310 (8%) Query: 28 RPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLL 87 R G G G V + T +VAIKK+ Q+ R + + + +++H NI+ L Sbjct: 29 RMAGQGTFGTVQLGKEKSTGMSVAIKKV---IQDPRFRNRELQIMQDLAVLHHPNIVQLQ 85 Query: 88 NAFTPQRNLEEFQDVYL--VMELMDANLCQVI------QMDLDHDRMSYLLYQML--CGI 137 + F + +D+YL VME + L + Q+ + L+Q++ G Sbjct: 86 SYFYTLGERDR-RDIYLNVVMEYVPDTLHRCCRNYYRRQVAPPPILIKVFLFQLIRSIGC 144 Query: 138 KHLHSAGIIHRDLKPSNIVV-KADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVIL 196 HL S + HRD+KP N++V +AD TLK+ DFG A+ + Y+ +RYYRAPE+I Sbjct: 145 LHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKLSPSEPNVAYICSRYYRAPELIF 204 Query: 197 G-MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVR 255 G YT VDIWSVGCI EM+ G +F G + Q ++I+ LG PS +++L P+ Sbjct: 205 GNQHYTTAVDIWSVGCIFAEMMLGEPIFRGDNSAGQLHEIVRVLGCPSREVLRKLNPSHT 264 Query: 256 NYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEAL 315 + + G + +F D +S + A +A +LLS +L PE+R+ EAL Sbjct: 265 DV--DLYNSKGIPWSNVFSD---------HSLKDAKEAYDLLSALLQYLPEERMKPYEAL 313 Query: 316 KHEYINVWYD 325 H Y + +D Sbjct: 314 CHPYFDELHD 323 >5G6V-A nrPDB Length = 324 Score = 132 bits (333), Expect = 2e-31, Method: Compositional matrix adjust. Identities = 94/306 (30%), Positives = 146/306 (47%), Gaps = 33/306 (10%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNI 83 YI L +G G V +T VA+K++ + A RE L+K + H NI Sbjct: 4 YIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCT-AIREVSLLKDLKHANI 62 Query: 84 IGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQ---MDLDHDRMSYLLYQMLCGIKHL 140 + L + +++L LV E +D +L Q + ++ + L+Q+L G+ + Sbjct: 63 VTLHDIIHTEKSLT------LVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYC 116 Query: 141 HSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGT-TFMMTPYVVTRYYRAPEVILG-M 198 H ++HRDLKP N+++ LK+ DFGLAR T VVT +YR P+++LG Sbjct: 117 HRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYDNEVVTLWYRPPDILLGST 176 Query: 199 GYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPS----PSFMQRLQPTV 254 Y+ +D+W VGCI EM G LFPG+ +Q + I LGTP+ P + + Sbjct: 177 DYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKT 236 Query: 255 RNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEA 314 NY P+Y + P R SD +LL+K+L + RIS ++A Sbjct: 237 YNY----PKYRAEALLSHAP-------------RLDSDGADLLTKLLQFEGRNRISAEDA 279 Query: 315 LKHEYI 320 +KH + Sbjct: 280 MKHPFF 285 >5EFQ-A nrPDB Length = 347 Score = 128 bits (321), Expect = 4e-30, Method: Compositional matrix adjust. Identities = 90/316 (28%), Positives = 153/316 (48%), Gaps = 26/316 (8%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNA 89 IG G G V A D T + VA+KK+ + A RE K+++ + H++II + Sbjct: 19 IGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEI 78 Query: 90 FTPQRNLEEFQD----VYLVMELMDANLCQVIQMDLDH---DRMSYLLYQMLCGIKHLHS 142 T + + +F+ YLV E MD +L +++ L H + + + Q++ G+ + H Sbjct: 79 VTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHK 138 Query: 143 AGIIHRDLKPSNIVVKADCTLKILDFGLAR--TAGTTFMMTPYVVTRYYRAPEVILGMG- 199 +HRD+K SNI++ +K+ DFGLAR ++ + T V+T +YR PE++LG Sbjct: 139 KNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGEER 198 Query: 200 YTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVE 259 YT +D+WS GCI+GE+ +F + Q I G+P P+ + P V Sbjct: 199 YTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPA----VWPDVIKLP- 253 Query: 260 NRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEY 319 F+ + P + + + A +L ML +DP +R + ++AL+ E+ Sbjct: 254 --------YFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEF 305 Query: 320 INVWYDAEEVDAPAPE 335 + D E P P+ Sbjct: 306 LR---DVEPSKMPPPD 318 >4AGU-A nrPDB Length = 311 Score = 127 bits (319), Expect = 7e-30, Method: Compositional matrix adjust. Identities = 95/328 (28%), Positives = 148/328 (45%), Gaps = 33/328 (10%) Query: 22 SRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHK 81 +Y + IG G+ G+V + T Q VAIKK + K A RE +++K + H Sbjct: 3 EKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKHP 62 Query: 82 NIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVI---QMDLDHDRMSYLLYQMLCGIK 138 N++ LL F +R L +LV E D + + Q + + + +Q L + Sbjct: 63 NLVNLLEVFRRKRRL------HLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVN 116 Query: 139 HLHSAGIIHRDLKPSNIVVKADCTLKILDFGLART-AGTTFMMTPYVVTRYYRAPEVILG 197 H IHRD+KP NI++ +K+ DFG AR G + V TR+YR+PE+++G Sbjct: 117 FCHKHNCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYDDEVATRWYRSPELLVG 176 Query: 198 -MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRN 256 Y VD+W++GC+ E++ G L+PG +DQ I + LG P Q + Sbjct: 177 DTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVF--STNQ 234 Query: 257 YVENRPRYTGYSFDRL---FPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDE 313 Y + L FP+ +P A LL L +DP +R++ ++ Sbjct: 235 YFSGVKIPDPEDMEPLELKFPNISYP-------------ALGLLKGCLHMDPTERLTCEQ 281 Query: 314 ALKHEYINVWYD----AEEVDAPAPEPY 337 L H Y + A+E D PA Y Sbjct: 282 LLHHPYFENIREIEDLAKEHDKPAENLY 309 >4NST-A nrPDB Length = 351 Score = 125 bits (315), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 86/303 (28%), Positives = 149/303 (49%), Gaps = 25/303 (8%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNA 89 IG G G V A D T + VA+KK+ + A RE K+++ + H++++ + Sbjct: 21 IGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEI 80 Query: 90 FTPQRNLEEFQD----VYLVMELMDANLCQVIQMDLDH---DRMSYLLYQMLCGIKHLHS 142 T +++ +F+ YLV E MD +L +++ L H D + + Q++ G+++ H Sbjct: 81 VTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHK 140 Query: 143 AGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPY---VVTRYYRAPEVILGMG 199 +HRD+K SNI++ +K+ DFGLAR + PY V+T +YR PE++LG Sbjct: 141 KNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSE-ESRPYTNKVITLWYRPPELLLGEE 199 Query: 200 -YTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYV 258 YT +D+WS GCI+GE+ +F + Q I G+P P+ + P V Sbjct: 200 RYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPA----VWPDVIKLP 255 Query: 259 ENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHE 318 F+ + P + + S A +LL ML +DP +R + ++ L+ + Sbjct: 256 ---------YFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSD 306 Query: 319 YIN 321 ++ Sbjct: 307 FLK 309 >3MIA-A nrPDB Length = 351 Score = 124 bits (310), Expect = 9e-29, Method: Compositional matrix adjust. Identities = 96/332 (28%), Positives = 152/332 (45%), Gaps = 48/332 (14%) Query: 22 SRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHK 81 S+Y L IG G G V A T Q VA+KK+ + A RE K+++L+ H+ Sbjct: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHE 76 Query: 82 NIIGLL----NAFTPQRNLEEFQDVYLVMELMD---ANLCQVIQMDLDHDRMSYLLYQML 134 N++ L+ +P + +YLV + + A L + + + ++ +L Sbjct: 77 NVVNLIEICRTKASPYNRCK--GSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLL 134 Query: 135 CGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTP-----YVVTRYY 189 G+ ++H I+HRD+K +N+++ D LK+ DFGLAR P VVT +Y Sbjct: 135 NGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWY 194 Query: 190 RAPEVILG-MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQ 248 R PE++LG Y +D+W GCIM EM + G Q I + G+ +P Sbjct: 195 RPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPE--- 251 Query: 249 RLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASD----------ARNLLS 298 + P V NY +++L + + +RK D A +L+ Sbjct: 252 -VWPNVDNY---------ELYEKL--------ELVKGQKRKVKDRLKAYVRDPYALDLID 293 Query: 299 KMLVIDPEQRISVDEALKHEYINVWYDAEEVD 330 K+LV+DP QRI D+AL H++ W D D Sbjct: 294 KLLVLDPAQRIDSDDALNHDFF--WSDPMPSD 323 >2YCR-A nrPDB Length = 323 Score = 122 bits (306), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 93/320 (29%), Positives = 155/320 (48%), Gaps = 64/320 (20%) Query: 19 TIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRA------YREF 72 + YI + +GSGA G V A++ T + VAIK +S+ + A+ A E Sbjct: 7 ALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEI 66 Query: 73 KLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMS----- 127 +++K +NH II + N F + +D Y+V+ELM+ ++ + + R+ Sbjct: 67 EILKKLNHPCIIKIKNFF-------DAEDYYIVLELMEGG--ELFDKVVGNKRLKEATCK 117 Query: 128 YLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKA---DCTLKILDFGLARTAGTTFMMTPYV 184 YQML +++LH GIIHRDLKP N+++ + DC +KI DFG ++ G T +M Sbjct: 118 LYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLC 177 Query: 185 VTRYYRAPEVILGM---GYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGT 241 T Y APEV++ + GY VD WS+G I+ + G +P Sbjct: 178 GTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSG---YP----------------- 217 Query: 242 PSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKML 301 P R Q ++++ + + Y+F P + S + A +L+ K+L Sbjct: 218 --PFSEHRTQVSLKDQITS----GKYNF--------IPEVWAEVSEK----ALDLVKKLL 259 Query: 302 VIDPEQRISVDEALKHEYIN 321 V+DP+ R + +EAL+H ++ Sbjct: 260 VVDPKARFTTEEALRHPWLQ 279 >5JN2-A nrPDB Length = 525 Score = 122 bits (305), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 91/316 (28%), Positives = 145/316 (45%), Gaps = 48/316 (15%) Query: 23 RYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLS-RPFQNVTHAKRAYREFKLMKLVNHK 81 RY R +G G+ G V D IT Q A+K +S R + T + RE +L+K ++H Sbjct: 68 RYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDHP 127 Query: 82 NIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGIKHLH 141 NI+ L F + +VY EL D + + ++D R ++ Q+L GI ++H Sbjct: 128 NIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAAR---IIRQVLSGITYMH 184 Query: 142 SAGIIHRDLKPSNIVVKA---DCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGM 198 I+HRDLKP N+++++ D ++I+DFGL+ + M + T YY APEV+ G Sbjct: 185 KNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVLHGT 244 Query: 199 GYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYV 258 Y E D+WS G I+ ++ G F G + D K+ + Y Sbjct: 245 -YDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKG-----------------KYT 286 Query: 259 ENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHE 318 P++ ++ + A++L+ KML P RIS +AL HE Sbjct: 287 FELPQW----------------------KKVSESAKDLIRKMLTYVPSMRISARDALDHE 324 Query: 319 YINVWYDAEEVDAPAP 334 +I Y E++ P Sbjct: 325 WIQT-YTKEQISVDVP 339 >3I6U-A nrPDB Length = 419 Score = 121 bits (304), Expect = 4e-28, Method: Compositional matrix adjust. Identities = 90/319 (28%), Positives = 154/319 (48%), Gaps = 64/319 (20%) Query: 19 TIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRA------YREF 72 + YI + +GSGA G V A++ T + VAI+ +S+ + A+ A E Sbjct: 132 ALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSAREADPALNVETEI 191 Query: 73 KLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMS----- 127 +++K +NH II + N F + +D Y+V+ELM+ ++ + + R+ Sbjct: 192 EILKKLNHPCIIKIKNFF-------DAEDYYIVLELMEGG--ELFDKVVGNKRLKEATCK 242 Query: 128 YLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKA---DCTLKILDFGLARTAGTTFMMTPYV 184 YQML +++LH GIIHRDLKP N+++ + DC +KI DFG ++ G T +M Sbjct: 243 LYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLC 302 Query: 185 VTRYYRAPEVILGM---GYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGT 241 T Y APEV++ + GY VD WS+G I+ + G P ++H Q + + +Q+ + Sbjct: 303 GTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSG--YPPFSEHRTQVS-LKDQITS 359 Query: 242 PSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKML 301 +F+ + V + A +L+ K+L Sbjct: 360 GKYNFIPEVWAEV-----------------------------------SEKALDLVKKLL 384 Query: 302 VIDPEQRISVDEALKHEYI 320 V+DP+ R + +EAL+H ++ Sbjct: 385 VVDPKARFTTEEALRHPWL 403 >5Y86-A nrPDB Length = 588 Score = 121 bits (304), Expect = 5e-28, Method: Compositional matrix adjust. Identities = 94/329 (28%), Positives = 157/329 (47%), Gaps = 43/329 (13%) Query: 23 RYINLRPIGSGAQGIVCAAYDTITQQNVAIKKL---SRPFQNVTHAKRAYREFKLMKLVN 79 RY L+ IG G+ G V YD +Q VA+K + R + R K Sbjct: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTG 267 Query: 80 HKNIIGLLNAFTPQRNLEEFQD-VYLVMELMDANLCQVIQMDLDHDRMSYLLYQ----ML 134 N+I +L +FT F++ V + EL+ +L ++I+ + L+ + +L Sbjct: 268 SMNVIHMLESFT-------FRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSIL 320 Query: 135 CGIKHLHSAGIIHRDLKPSNIVVK--ADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAP 192 + LH IIH DLKP NI++K + K++DFG + + Y+ +R+YRAP Sbjct: 321 QSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG--SSCFEYQKLYTYIQSRFYRAP 378 Query: 193 EVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQP 252 E+ILG Y+ +DIWS GCI+ E++ G LFPG D DQ ++E LG P P +++ + Sbjct: 379 EIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSK- 437 Query: 253 TVRNYVENR--PRYTGYSFDRLFPDG---LFPNDNNQNSRRKASDARN------------ 295 + ++ ++ PRY + DG L + + +R +++ Sbjct: 438 RAKYFINSKGIPRYCSVTTQA---DGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYL 494 Query: 296 ---LLSKMLVIDPEQRISVDEALKHEYIN 321 L + L DP R++ +AL+H +I+ Sbjct: 495 FIEFLKRCLHWDPSARLTPAQALRHPWIS 523 >3MA6-A nrPDB Length = 298 Score = 119 bits (299), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 88/305 (28%), Positives = 141/305 (46%), Gaps = 47/305 (15%) Query: 23 RYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLS-RPFQNVTHAKRAYREFKLMKLVNHK 81 RY R +G G+ G V D IT Q A+K +S R + T + RE +L+K ++H Sbjct: 33 RYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDHP 92 Query: 82 NIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGIKHLH 141 NI+ L F + +VY EL D + + ++D R ++ Q+L GI ++H Sbjct: 93 NIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAAR---IIRQVLSGITYMH 149 Query: 142 SAGIIHRDLKPSNIVVKA---DCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGM 198 I+HRDLKP N+++++ D ++I+DFGL+ + M + T YY APEV+ G Sbjct: 150 KNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVLHGT 209 Query: 199 GYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYV 258 Y E D+WS G I+ ++ G F G + D K+ + Y Sbjct: 210 -YDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKG-----------------KYT 251 Query: 259 ENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHE 318 P++ ++ + A++L+ KML P RIS +AL HE Sbjct: 252 FELPQW----------------------KKVSESAKDLIRKMLTYVPSMRISARDALDHE 289 Query: 319 YINVW 323 +I + Sbjct: 290 WIQTY 294 >5ZTN-A nrPDB Length = 429 Score = 119 bits (297), Expect = 3e-27, Method: Compositional matrix adjust. Identities = 95/327 (29%), Positives = 154/327 (47%), Gaps = 41/327 (12%) Query: 23 RYINLRPIGSGAQGIVCAAYDTITQQNVAIKKL---SRPFQNVTHAKRAYREFKLMKLVN 79 RY L+ IG G+ G V AYD Q+VA+K + R + R + N Sbjct: 98 RYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDN 157 Query: 80 HKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMD----LDHDRMSYLLYQMLC 135 N+I +L FT + + + + EL+ NL ++I+ + + + +L Sbjct: 158 TMNVIHMLENFTFRNH------ICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQ 211 Query: 136 GIKHLHSAGIIHRDLKPSNIVVK--ADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPE 193 + LH IIH DLKP NI++K +K++DFG + + Y+ +R+YRAPE Sbjct: 212 CLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFG--SSCYEHQRVYTYIQSRFYRAPE 269 Query: 194 VILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPT 253 VILG Y +D+WS+GCI+ E++ G L PG D DQ +IE LG PS + + Sbjct: 270 VILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASK-R 328 Query: 254 VRNYVENR--PRYTGYSFDRLFPDGLFPNDNNQNSR---RKASDAR-------------- 294 +N+V ++ PRY + DG + ++ R R ++R Sbjct: 329 AKNFVSSKGYPRYCTVT---TLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLF 385 Query: 295 -NLLSKMLVIDPEQRISVDEALKHEYI 320 + L + L DP R++ +AL+H ++ Sbjct: 386 LDFLKQCLEWDPAVRMTPGQALRHPWL 412 >4RGJ-A nrPDB Length = 520 Score = 119 bits (297), Expect = 3e-27, Method: Compositional matrix adjust. Identities = 94/331 (28%), Positives = 154/331 (46%), Gaps = 52/331 (15%) Query: 13 VGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRP-FQNVTHAKRAYRE 71 + ++N + +Y ++ +G G+ G V + D T AIK +S+ + T + RE Sbjct: 51 IQNSNVVFNEQYKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKESLLRE 110 Query: 72 FKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLY 131 +L+K+++H NI+ L F DVY EL D + + ++D R ++ Sbjct: 111 VELLKMLDHINIMKLYEFFEDNNYYYLVSDVYTGGELFDEIISRKRFYEIDAAR---IIK 167 Query: 132 QMLCGIKHLHSAGIIHRDLKPSNIVV----KADCTLKILDFGLARTAGTTFMMTPYVVTR 187 Q+L GI ++H ++HRDLKP NI++ K D +KI+DFGL+ + M + T Sbjct: 168 QILSGITYMHKNNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHFEYSKKMKDKIGTA 227 Query: 188 YYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFM 247 YY AP+V+ G Y E DIWS G I+ ++ G F G++ D K+ Sbjct: 228 YYIAPDVLHGT-YDEKCDIWSCGVILYILLSGCPPFNGSNEYDILKKV------------ 274 Query: 248 QRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASD-ARNLLSKMLVIDPE 306 Y + P++ +K SD A++L+ KML+ Sbjct: 275 -----EAGKYTFDLPQF-----------------------KKISDKAKDLIKKMLMYTSA 306 Query: 307 QRISVDEALKHEYINVW--YDAEEVDAPAPE 335 RIS +AL+HE+I + D +D P+ E Sbjct: 307 VRISARDALEHEWIKMMTSKDNLNIDIPSLE 337 >4IAN-A nrPDB Length = 358 Score = 117 bits (293), Expect = 7e-27, Method: Compositional matrix adjust. Identities = 99/342 (28%), Positives = 159/342 (46%), Gaps = 31/342 (9%) Query: 3 TAQHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTI-TQQNVAIKKLSRPFQN 61 T +Y V +G+ + RY G G V A D Q VA+K + N Sbjct: 14 TDAEGYYRVNIGEV---LDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIR---NN 67 Query: 62 VTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQ--- 118 K +E + +K +N + + R+ Q + LV E + NL +V++ Sbjct: 68 ELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYG 127 Query: 119 --MDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCT-LKILDFGLARTAG 175 + L + Q+ +K L I+H D+KP NI+V T LK+ DFG A Sbjct: 128 KDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASHVA 187 Query: 176 TTFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPG--TDHIDQW- 232 +TPY+V+R+YRAPE+I+G Y +D+WSVGC + E+ G +LFPG +H+ + Sbjct: 188 DN-DITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLA 246 Query: 233 --------NKIIEQLGTPSPSFMQRLQPTV--RNYVENRPRYTGYS----FDRLFPDGLF 278 NK+I + F Q L + V R + T S L D + Sbjct: 247 MDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLADLIG 306 Query: 279 PNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEYI 320 ++ R+K ++LL ++L++DP +RIS+++AL+H +I Sbjct: 307 CQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFI 348 >4MVF-A nrPDB Length = 506 Score = 117 bits (292), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 86/307 (28%), Positives = 143/307 (46%), Gaps = 54/307 (17%) Query: 20 IHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVN 79 + +YI +G G G V D +T Q AIK+ + + + R ++E ++MK ++ Sbjct: 55 LEDKYIIDEKLGQGTYGCVYKGIDKVTNQLYAIKEEKK--DRLKNINRFFQEIEIMKKLD 112 Query: 80 HKNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN--LCQVIQ-MDLDHDRMSYLLYQMLCG 136 H NI+ L + E +YL+MEL +I+ + ++ Q+ Sbjct: 113 HPNIVKLYETY------ENDNYIYLIMELCSGRELFDSIIENGSFTEKNAATIMKQIFSA 166 Query: 137 IKHLHSAGIIHRDLKPSNIVVKA---DCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPE 193 I +LHS I+HRDLKP N + ++ D LKI+DFGL++ GT T T YY AP+ Sbjct: 167 IFYLHSLNIVHRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFTTTKAGTPYYVAPQ 226 Query: 194 VILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPT 253 V+ G Y + DIWS G IM ++ G F G D N++++++ F + + Sbjct: 227 VLDGK-YDKKCDIWSSGVIMYTLLCGYPPFYG----DTDNEVLKKVKKGEFCFYENDWGS 281 Query: 254 VRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDE 313 + +SDA+NL++K+L +P +R +++E Sbjct: 282 I-----------------------------------SSDAKNLITKLLTYNPNERCTIEE 306 Query: 314 ALKHEYI 320 AL H +I Sbjct: 307 ALNHPWI 313 >3DFA-A nrPDB Length = 286 Score = 116 bits (291), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 90/311 (28%), Positives = 144/311 (46%), Gaps = 52/311 (16%) Query: 19 TIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLV 78 T RY + +G G+ G V D ITQQ A+K +++ RE +L+K + Sbjct: 19 TFAERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKL 78 Query: 79 NHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDL--DHDRMSYLLYQMLCG 136 +H NI+ L + ++Y EL D ++I+ +HD + ++ Q+ G Sbjct: 79 DHPNIMKLFEILEDSSSFYIVGELYTGGELFD----EIIKRKRFSEHD-AARIIKQVFSG 133 Query: 137 IKHLHSAGIIHRDLKPSNIVVKA---DCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPE 193 I ++H I+HRDLKP NI++++ DC +KI+DFGL+ M + T YY APE Sbjct: 134 ITYMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPE 193 Query: 194 VILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPT 253 V+ G Y E D+WS G I+ ++ G F G + D ++R++ Sbjct: 194 VLRGT-YDEKCDVWSAGVILYILLSGTPPFYGKNEYD---------------ILKRVE-- 235 Query: 254 VRNYVENRPRYTG-YSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVD 312 TG Y+FD P R + DA++L+ KML P RI+ Sbjct: 236 -----------TGKYAFD--LP----------QWRTISDDAKDLIRKMLTFHPSLRITAT 272 Query: 313 EALKHEYINVW 323 + L+H +I + Sbjct: 273 QCLEHPWIQKY 283 >2WO6-A nrPDB Length = 382 Score = 116 bits (291), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 99/326 (30%), Positives = 155/326 (47%), Gaps = 44/326 (13%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIK--KLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLL 87 IG G+ G V AYD + Q+ VAIK K + F N +A E +L++L+N + Sbjct: 62 IGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLN-----QAQIEVRLLELMNKHDTEMKY 116 Query: 88 NAFTPQRNLEEFQDVYLVMELMDANLCQVIQ------MDLDHDRMSYLLYQMLCGIKHLH 141 +R+ + LV E++ NL +++ + L+ R QM + L Sbjct: 117 YIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRK--FAQQMCTALLFLA 174 Query: 142 SA--GIIHRDLKPSNIVV--KADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILG 197 + IIH DLKP NI++ +KI+DFG + G + Y+ +R+YR+PEV+LG Sbjct: 175 TPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQR--IYQYIQSRFYRSPEVLLG 232 Query: 198 MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNY 257 M Y +D+WS+GCI+ EM G LF G + +DQ NKI+E LG P P+ + P R + Sbjct: 233 MPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIP-PAHILDQAPKARKF 291 Query: 258 VENRP------RYTGYSFDRLFPDG------LFPNDNNQNSRRKASDA----------RN 295 E P + T P G + + R+A ++ ++ Sbjct: 292 FEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKD 351 Query: 296 LLSKMLVIDPEQRISVDEALKHEYIN 321 L+ +ML DP+ RI AL+H + Sbjct: 352 LILRMLDYDPKTRIQPYYALQHSFFK 377 >3NCG-A nrPDB Length = 486 Score = 116 bits (291), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 87/310 (28%), Positives = 144/310 (46%), Gaps = 50/310 (16%) Query: 19 TIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLV 78 T RY + +G G+ G V D ITQQ A+K +++ RE +L+K + Sbjct: 19 TFAERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKL 78 Query: 79 NHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMD--LDHDRMSYLLYQMLCG 136 +H NI+ L + ++Y EL D ++I+ +HD + ++ Q+ G Sbjct: 79 DHPNIMKLFEILEDSSSFYIVGELYTGGELFD----EIIKRKRFSEHD-AARIIKQVFSG 133 Query: 137 IKHLHSAGIIHRDLKPSNIVVKA---DCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPE 193 I ++H I+HRDLKP NI++++ DC +KI+DFGL+ M + T YY APE Sbjct: 134 ITYMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPE 193 Query: 194 VILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPT 253 V+ G Y E D+WS G I+ ++ G F G + D I++++ T +F Sbjct: 194 VLRGT-YDEKCDVWSAGVILYILLSGTPPFYGKNEYD----ILKRVETGKYAF------- 241 Query: 254 VRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDE 313 + P++ R + DA++L+ KML P RI+ + Sbjct: 242 ------DLPQW----------------------RTISDDAKDLIRKMLTFHPSLRITATQ 273 Query: 314 ALKHEYINVW 323 L+H +I + Sbjct: 274 CLEHPWIQKY 283 >3LIJ-A nrPDB Length = 494 Score = 115 bits (287), Expect = 4e-26, Method: Compositional matrix adjust. Identities = 89/315 (28%), Positives = 146/315 (46%), Gaps = 48/315 (15%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNI 83 Y ++ +GSGA G V D +T AIK + + + + + E ++KL++H NI Sbjct: 39 YQRVKKLGSGAYGEVLLCRDKVTHVERAIKIIRKTSVSTSSNSKLLEEVAVLKLLDHPNI 98 Query: 84 IGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVI-QMDLDHDRMSYLLYQMLCGIKHLHS 142 + L + F +RN + Y EL D ++I +M + + ++ Q+L G+ +LH Sbjct: 99 MKLYDFFEDKRNYYLVMECYKGGELFD----EIIHRMKFNEVDAAVIIKQVLSGVTYLHK 154 Query: 143 AGIIHRDLKPSNIVVKA---DCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMG 199 I+HRDLKP N+++++ D +KI+DFGL+ M + T YY APEV L Sbjct: 155 HNIVHRDLKPENLLLESKEKDALIKIVDFGLSAVFENQKKMKERLGTAYYIAPEV-LRKK 213 Query: 200 YTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVE 259 Y E D+WS+G I+ ++ G F G Q Q +R + Sbjct: 214 YDEKCDVWSIGVILFILLAGYPPFGG----------------------QTDQEILRKVEK 251 Query: 260 NRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEY 319 + Y+FD P N + A++L+ +ML D ++RIS +AL+H + Sbjct: 252 GK-----YTFDS-------PEWKNV-----SEGAKDLIKQMLQFDSQRRISAQQALEHPW 294 Query: 320 INVWYDAEEVDAPAP 334 I +E P Sbjct: 295 IKEMCSKKESGIELP 309 >4CRL-A nrPDB Length = 406 Score = 112 bits (281), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 82/286 (28%), Positives = 141/286 (49%), Gaps = 46/286 (16%) Query: 68 AYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQ--------- 118 A RE L++ + H N+I L F + + V+L+ + + +L +I+ Sbjct: 66 ACREIALLRELKHPNVISLQKVFLSHAD----RKVWLLFDYAEHDLWHIIKFHRASKANK 121 Query: 119 --MDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCT----LKILDFGLAR 172 + L + LLYQ+L GI +LH+ ++HRDLKP+NI+V + +KI D G AR Sbjct: 122 KPVQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFAR 181 Query: 173 TAGTTFM----MTPYVVTRYYRAPEVILGM-GYTENVDIWSVGCIMGEMIRGGVLF---- 223 + + P VVT +YRAPE++LG YT+ +DIW++GCI E++ +F Sbjct: 182 LFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQ 241 Query: 224 -----PGTDHIDQWNKIIEQLGTPSPSFMQRLQ--PTVRNYVEN--RPRYTGYSFDRLFP 274 H DQ ++I +G P+ + ++ P +++ R YT S + Sbjct: 242 EDIKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYM- 300 Query: 275 DGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEYI 320 ++ + S A +LL K+L +DP +RI+ ++A++ Y Sbjct: 301 --------EKHKVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYF 338 >5ES1-A nrPDB Length = 328 Score = 112 bits (280), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 85/327 (25%), Positives = 145/327 (44%), Gaps = 58/327 (17%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNI 83 Y LR IG G V A +T + VAIK + + N + ++ +RE ++MK +NH NI Sbjct: 17 YRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNI 76 Query: 84 IGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMS-----YLLYQMLCGIK 138 + L ++ L YLVME A +V + H RM Q++ + Sbjct: 77 VKLFEVIETEKTL------YLVMEYASAG--EVFDYLVSHGRMKEKEARAKFRQIVSAVH 128 Query: 139 HLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGM 198 + H I+HRDLK N+++ A+ +KI DFG + + + + Y APE+ G Sbjct: 129 YCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGK 188 Query: 199 GY-TENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNY 257 Y VDIWS+G I+ ++ G + F G + ++ L+ V Sbjct: 189 KYDGPEVDIWSLGVILYTLVSGSLPFDGHN-------------------LKELRERVLRG 229 Query: 258 VENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKH 317 P Y ++D ++L + LV++P +R ++++ +K Sbjct: 230 KYRVPFYM------------------------STDCESILRRFLVLNPAKRCTLEQIMKD 265 Query: 318 EYINVWYDAEEVDAPAPEPYDHSVDER 344 ++IN+ Y+ EE+ P EP + D + Sbjct: 266 KWINIGYEGEELK-PYTEPEEDFGDTK 291 >3HZT-A nrPDB Length = 467 Score = 110 bits (275), Expect = 9e-25, Method: Compositional matrix adjust. Identities = 91/305 (29%), Positives = 138/305 (45%), Gaps = 47/305 (15%) Query: 20 IHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAY-REFKLMKLV 78 + RY ++ +GSGA G V D +T AIK + + T A E ++K + Sbjct: 2 LSDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQL 61 Query: 79 NHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGIK 138 +H NI+ L F +RN +VY EL D + + ++D + ++ Q+L G Sbjct: 62 DHPNIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILRQKFSEVD---AAVIMKQVLSGTT 118 Query: 139 HLHSAGIIHRDLKPSNIVVKA---DCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVI 195 +LH I+HRDLKP N+++++ D +KI+DFGL+ M + T YY APEV Sbjct: 119 YLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAPEV- 177 Query: 196 LGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVR 255 L Y E D+WS G I+ ++ G P F + + Sbjct: 178 LRKKYDEKCDVWSCGVILYILLCG-----------------------YPPFGGQTDQEIL 214 Query: 256 NYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEAL 315 VE +SFD P D Q S +A+ L+ ML +P +RIS +EAL Sbjct: 215 KRVEKGK----FSFD--------PPDWTQVS----DEAKQLVKLMLTYEPSKRISAEEAL 258 Query: 316 KHEYI 320 H +I Sbjct: 259 NHPWI 263 >4YZB-A nrPDB Length = 491 Score = 110 bits (275), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 96/334 (28%), Positives = 154/334 (46%), Gaps = 55/334 (16%) Query: 7 QHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLS-RPFQNVTHA 65 QH T D RY R +G G+ G V D +T Q A+K +S R + T Sbjct: 22 QHSTAAFSD-------RYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTDK 74 Query: 66 KRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDR 125 + +E +L+K ++H NI+ L F + +VY EL D + + ++D R Sbjct: 75 ELLLKEVELLKKLDHPNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAAR 134 Query: 126 MSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVV---KADCTLKILDFGLARTAGTTFMMTP 182 ++ Q+L GI ++H I+HRDLKP N+++ + D ++I+DFGL+ +T M Sbjct: 135 ---IIRQVLSGITYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKD 191 Query: 183 YVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTP 242 + T YY APEV+ G Y E D+WS G I+ ++ G F G + D K+ Sbjct: 192 KIGTAYYIAPEVLHGT-YDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKV------- 243 Query: 243 SPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLV 302 + ++T FD P ++ + A++L+ KML Sbjct: 244 -----------------EKGKFT---FD--LP----------QWKKVSEPAKDLIRKMLA 271 Query: 303 IDPEQRISVDEALKHEYINVWYDA-EEVDAPAPE 335 P RIS +AL+HE++ A + +D P+ E Sbjct: 272 YVPTMRISARDALEHEWLKTTDAATDSIDVPSLE 305 >3DXN-A nrPDB Length = 287 Score = 110 bits (275), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 92/305 (30%), Positives = 141/305 (46%), Gaps = 47/305 (15%) Query: 20 IHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAY-REFKLMKLV 78 + RY ++ +GSGA G V D +T AIK + + T A E ++K + Sbjct: 19 LSDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQL 78 Query: 79 NHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGIK 138 +H NI+ L F +RN +VY EL D + + ++D + ++ Q+L G Sbjct: 79 DHPNIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILRQKFSEVD---AAVIMKQVLSGTT 135 Query: 139 HLHSAGIIHRDLKPSNIVVKA---DCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVI 195 +LH I+HRDLKP N+++++ D +KI+DFGL+ M + T YY APEV Sbjct: 136 YLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAPEV- 194 Query: 196 LGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVR 255 L Y E D+WS G I+ ++ G F G DQ ++R++ Sbjct: 195 LRKKYDEKCDVWSCGVILYILLCGYPPFGG--QTDQ-------------EILKRVEK--- 236 Query: 256 NYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEAL 315 +SFD P D Q S +A+ L+ ML +P +RIS +EAL Sbjct: 237 ---------GKFSFD--------PPDWTQVS----DEAKQLVKLMLTYEPSKRISAEEAL 275 Query: 316 KHEYI 320 H +I Sbjct: 276 NHPWI 280 >2JD5-A nrPDB Length = 373 Score = 110 bits (274), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 104/375 (27%), Positives = 169/375 (45%), Gaps = 51/375 (13%) Query: 22 SRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHK 81 +RYI +R +G G V A D + +VA+K + + + + A E KL++ VN Sbjct: 19 ARYILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVR---GDKVYTEAAEDEIKLLQRVNDA 75 Query: 82 N-----------IIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLL 130 + I+ LL+ F + V +V E++ NL +I+ +H R L+ Sbjct: 76 DNTKEDSMGANHILKLLDHFNHKG--PNGVHVVMVFEVLGENLLALIK-KYEH-RGIPLI 131 Query: 131 Y------QMLCGIKHLHS-AGIIHRDLKPSNIVVK-ADCTLKILDFGLARTAGTTFMMTP 182 Y Q+L G+ ++H GIIH D+KP N++++ D ++ +A + Sbjct: 132 YVKQISKQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNACWYDEH 191 Query: 183 Y---VVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLF---------PGTDHID 230 Y + TR YR+PEV+LG + DIWS C++ E+I G LF DHI Sbjct: 192 YTNSIQTREYRSPEVLLGAPWGCGADIWSTACLIFELITGDFLFEPDEGHSYTKDDDHIA 251 Query: 231 QWNKIIEQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKA 290 Q IIE LG PS++ R R + +R S + +P + + S+ +A Sbjct: 252 Q---IIELLGE-LPSYLLRNGKYTRTFFNSRGLLRNISKLKFWPLEDVLTEKYKFSKDEA 307 Query: 291 SDARNLLSKMLVIDPEQRISVDEALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQ 350 + + LS ML +DP +R + H ++ EE+ P E Y D + Sbjct: 308 KEISDFLSPMLQLDPRKRADAGGLVNHPWLKDTLGMEEIRVPDRELYGSGSD-----IPG 362 Query: 351 WKELIYEEVMDYEAH 365 W +EEV D++ H Sbjct: 363 W----FEEVRDHKRH 373 >5KZ7-A nrPDB Length = 346 Score = 109 bits (272), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 86/341 (25%), Positives = 149/341 (43%), Gaps = 58/341 (17%) Query: 27 LRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGL 86 L+ IG G V A +T + VA+K + + N + ++ +RE ++MK++NH NI+ L Sbjct: 38 LKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKL 97 Query: 87 LNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMS-----YLLYQMLCGIKHLH 141 ++ L YLVME A+ +V + H RM Q++ +++ H Sbjct: 98 FEVIETEKTL------YLVMEY--ASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCH 149 Query: 142 SAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGY- 200 I+HRDLK N+++ AD +KI DFG + + + + Y APE+ G Y Sbjct: 150 QKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYD 209 Query: 201 TENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVEN 260 VD+WS+G I+ ++ G + F G Q L+ + Sbjct: 210 GPEVDVWSLGVILYTLVSGSLPFDG----------------------QNLKELRERVLRG 247 Query: 261 RPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEYI 320 + R Y ++D NLL K L+++P +R ++++ +K ++ Sbjct: 248 KYRIPFYM---------------------STDCENLLKKFLILNPSKRGTLEQIMKDRWM 286 Query: 321 NVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYEEVMD 361 NV ++ +E+ P EP D R + EE+ D Sbjct: 287 NVGHEDDEL-KPYVEPLPDYKDPRRTELMVSMGYTREEIQD 326 >2QNJ-A nrPDB Length = 328 Score = 108 bits (269), Expect = 4e-24, Method: Compositional matrix adjust. Identities = 83/319 (26%), Positives = 142/319 (44%), Gaps = 58/319 (18%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNI 83 Y L+ IG G V A +T + VAIK + + N T ++ +RE ++MK++NH NI Sbjct: 14 YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNI 73 Query: 84 IGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMS-----YLLYQMLCGIK 138 + L ++ L YL+ME A+ +V + H RM Q++ ++ Sbjct: 74 VKLFEVIETEKTL------YLIMEY--ASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQ 125 Query: 139 HLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGM 198 + H I+HRDLK N+++ AD +KI DFG + + + + Y APE+ G Sbjct: 126 YCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGK 185 Query: 199 GY-TENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNY 257 Y VD+WS+G I+ ++ G + F G Q L+ Sbjct: 186 KYDGPEVDVWSLGVILYTLVSGSLPFDG----------------------QNLKELRERV 223 Query: 258 VENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKH 317 + + R Y ++D NLL + LV++P +R ++++ +K Sbjct: 224 LRGKYRIPFYM---------------------STDCENLLKRFLVLNPIKRGTLEQIMKD 262 Query: 318 EYINVWYDAEEVDAPAPEP 336 +IN ++ +E+ P EP Sbjct: 263 RWINAGHEEDEL-KPFVEP 280 >6O6Q-A nrPDB Length = 335 Score = 100 bits (250), Expect = 8e-22, Method: Compositional matrix adjust. Identities = 84/330 (25%), Positives = 166/330 (50%), Gaps = 30/330 (9%) Query: 1 MTTAQHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQ 60 ++T ++ + + + Y LR +G G V D ++ V IK L +P + Sbjct: 20 LSTKPQSYWDYDDLNIKWNPQENYEILRKLGRGKYSEVFLGIDLEKREKVVIKVL-KPVK 78 Query: 61 NVTHAKRAYREFKLMK-LVNHKNIIGLLNAF-TPQRNLEEFQDVYLVME-LMDANLCQVI 117 K+ RE ++K LV+ NII +L+ PQ L+ E + + + + Sbjct: 79 R----KKIKREISILKNLVDGPNIIAMLDVVREPQSKTPG-----LIFEHINNIDFRSLY 129 Query: 118 QMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCT-LKILDFGLART--A 174 D+D + + +Y++L + + HS GI+HRD+KP N+++ D L+++D+GLA Sbjct: 130 PTFTDYD-IRFYMYELLKALDYSHSMGIMHRDVKPHNVMIDHDKKLLRLIDWGLAEYYHP 188 Query: 175 GTTFMMTPYVVTRYYRAPEVILGMG-YTENVDIWSVGCIMGEMI-RGGVLFPGTDHIDQW 232 GT + + V +RY++ PE+++ Y ++D+WS GC++ M+ F G + DQ Sbjct: 189 GTEYNVR--VASRYFKGPELLVDYRLYDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQL 246 Query: 233 NKIIEQLGTPS-PSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKAS 291 +I+ LG+ + ++++ ++ E+ Y + R F N+NN++ + Sbjct: 247 VQIVRVLGSKNFKKYLEKYNISLGEEYEDIGYYNKRQWVR------FMNENNKDL--VSQ 298 Query: 292 DARNLLSKMLVIDPEQRISVDEALKHEYIN 321 + +L+ ++L D ++R++ EA+KH Y + Sbjct: 299 EFLDLIDRLLRYDHQERLTAKEAMKHAYFD 328 >3H4J-B nrPDB Length = 336 Score = 100 bits (248), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 86/303 (28%), Positives = 133/303 (43%), Gaps = 53/303 (17%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAK-RAYREFKLMKLVNHKN 82 YI +G G+ G V A TQQ VA+K +SR + R RE +KL+ H + Sbjct: 11 YIIRETLGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREISYLKLLRHPH 70 Query: 83 IIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVI--QMDLDHDRMSYLLYQMLCGIKHL 140 II L + T D+ +V+E L I + + D Q++C I++ Sbjct: 71 IIKLYDVITTP------TDIVMVIEYAGGELFDYIVEKKRMTEDEGRRFFQQIICAIEYC 124 Query: 141 HSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGY 200 H I+HRDLKP N+++ + +KI DFGL+ + + Y APEVI G Y Sbjct: 125 HRHKIVHRDLKPENLLLDDNLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVINGKLY 184 Query: 201 T-ENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVE 259 VD+WS G ++ M+ G + F D++ P+ +++ V YV Sbjct: 185 AGPEVDVWSCGIVLYVMLVGRLPFD-----DEF----------IPNLFKKVNSCV--YV- 226 Query: 260 NRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEY 319 PD L P A++L+ +M+V DP QRI++ E + + Sbjct: 227 -------------MPDFLSPG------------AQSLIRRMIVADPMQRITIQEIRRDPW 261 Query: 320 INV 322 NV Sbjct: 262 FNV 264 >4EQM-A nrPDB Length = 294 Score = 100 bits (248), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 74/212 (34%), Positives = 109/212 (51%), Gaps = 12/212 (5%) Query: 20 IHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHA-KRAYREFKLMKLV 78 I+ RY + +G G V A DTI VAIK + P + KR RE + Sbjct: 9 INERYKIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETLKRFEREVHNSSQL 68 Query: 79 NHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDA-NLCQVIQMD--LDHDRMSYLLYQMLC 135 +H+NI+ +++ EE YLVME ++ L + I+ L D Q+L Sbjct: 69 SHQNIVSMIDVD------EEDDCYYLVMEYIEGPTLSEYIESHGPLSVDTAINFTNQILD 122 Query: 136 GIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLART-AGTTFMMTPYVV-TRYYRAPE 193 GIKH H I+HRD+KP NI++ ++ TLKI DFG+A+ + T+ T +V+ T Y +PE Sbjct: 123 GIKHAHDMRIVHRDIKPQNILIDSNKTLKIFDFGIAKALSETSLTQTNHVLGTVQYFSPE 182 Query: 194 VILGMGYTENVDIWSVGCIMGEMIRGGVLFPG 225 G E DI+S+G ++ EM+ G F G Sbjct: 183 QAKGEATDECTDIYSIGIVLYEMLVGEPPFNG 214 >5XZW-A nrPDB Length = 471 Score = 100 bits (248), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 81/309 (26%), Positives = 140/309 (45%), Gaps = 64/309 (20%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNA 89 +G GA V A + T + A+K +S+ + + + RE ++++ +NH I+ L Sbjct: 204 VGQGAFATVKKAIERTTGKTFAVKIISKR-KVIGNMDGVTRELEVLQKLNHPRIVRLKGF 262 Query: 90 FTPQRNLEEFQDVYLVMELMDA-NLCQVIQM--DLDHDRMSYLLYQMLCGIKHLHSAGII 146 + E+ + Y+VME + +L + + D + Q+L IK++HS GI Sbjct: 263 Y------EDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSMGIS 316 Query: 147 HRDLKPSNIVVKAD--CTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMG----- 199 HRDLKP NI+++ D +KI DFGLA+ G M + T Y APEVI G Sbjct: 317 HRDLKPDNILIEQDDPVLVKITDFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSP 376 Query: 200 --------YTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQ 251 Y+ VD+WS+GC++ ++ G + F G+ +++ +Q+G S Sbjct: 377 DEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQ----DQLYKQIGRGS-------- 424 Query: 252 PTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISV 311 + +G + R + +AR+ + +L +DP R + Sbjct: 425 ---------------------YHEGPLKD------FRISEEARDFIDSLLQVDPNNRSTA 457 Query: 312 DEALKHEYI 320 +AL H +I Sbjct: 458 AKALNHPWI 466 >5X8I-B nrPDB Length = 346 Score = 100 bits (248), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 97/346 (28%), Positives = 161/346 (46%), Gaps = 45/346 (13%) Query: 8 HYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYD-TITQQNVAIKKLSRPFQNVTHAK 66 H + GD + +RY + +G GA G V D ++VA+K + +NV Sbjct: 2 HLICQSGDV---LSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIV----KNVDRYC 54 Query: 67 RAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQD---VYLVMELMDANLCQVIQMD--- 120 A R ++++ H N + F + LE F+ + +V EL+ + I+ + Sbjct: 55 EAARS--EIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFL 112 Query: 121 ---LDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIV-VKADCT-------------- 162 LDH R + YQ+ + LHS + H DLKP NI+ V++D T Sbjct: 113 PFRLDHIRK--MAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTL 170 Query: 163 ----LKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIR 218 +K++DFG A + V TR+YRAPEVIL +G+++ D+WS+GCI+ E Sbjct: 171 INPDIKVVDFGSATYDDEHH--STLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYL 228 Query: 219 GGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENRPRYTGY-SFDRLFPDGL 277 G +FP D + ++E++ P P M + + + +R + + S R Sbjct: 229 GFTVFPTHDSKEHL-AMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRAC 287 Query: 278 FPNDNNQNSRRKASDAR-NLLSKMLVIDPEQRISVDEALKHEYINV 322 P S+ + +L+ KML DP +RI++ EALKH + ++ Sbjct: 288 KPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDL 333 >6C9D-A nrPDB Length = 459 Score = 99.0 bits (245), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 61/206 (29%), Positives = 102/206 (49%), Gaps = 14/206 (6%) Query: 28 RPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLL 87 + IG G V A +T + VA+K + + N T ++ +RE ++MK++NH NI+ L Sbjct: 27 KTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLF 86 Query: 88 NAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMS-----YLLYQMLCGIKHLHS 142 ++ L YLVME A+ +V + H RM Q++ +++ H Sbjct: 87 EVIETEKTL------YLVMEY--ASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQ 138 Query: 143 AGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGY-T 201 I+HRDLK N+++ D +KI DFG + + + + Y APE+ G Y Sbjct: 139 KYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDEFCGSPPYAAPELFQGKKYDG 198 Query: 202 ENVDIWSVGCIMGEMIRGGVLFPGTD 227 VD+WS+G I+ ++ G + F G + Sbjct: 199 PEVDVWSLGVILYTLVSGSLPFDGQN 224 >2HAK-A nrPDB Length = 328 Score = 98.2 bits (243), Expect = 5e-21, Method: Compositional matrix adjust. Identities = 61/206 (29%), Positives = 102/206 (49%), Gaps = 14/206 (6%) Query: 28 RPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLL 87 + IG G V A +T + VA+K + + N T ++ +RE ++MK++NH NI+ L Sbjct: 21 KTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLF 80 Query: 88 NAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMS-----YLLYQMLCGIKHLHS 142 ++ L YLVME A+ +V + H RM Q++ +++ H Sbjct: 81 EVIETEKTL------YLVMEY--ASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQ 132 Query: 143 AGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGY-T 201 I+HRDLK N+++ D +KI DFG + + + + Y APE+ G Y Sbjct: 133 KYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDG 192 Query: 202 ENVDIWSVGCIMGEMIRGGVLFPGTD 227 VD+WS+G I+ ++ G + F G + Sbjct: 193 PEVDVWSLGVILYTLVSGSLPFDGQN 218 >2F57-A nrPDB Length = 317 Score = 97.1 bits (240), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 76/300 (25%), Positives = 136/300 (45%), Gaps = 51/300 (17%) Query: 26 NLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIG 85 N IG G+ GIVC A + T + VA+KK+ + + + E +M+ +H N++ Sbjct: 49 NFIKIGEGSTGIVCIATEKHTGKQVAVKKMD--LRKQQRRELLFNEVVIMRDYHHDNVVD 106 Query: 86 LLNAFTPQRNLEEFQDVYLVMELMDANLCQ--VIQMDLDHDRMSYLLYQMLCGIKHLHSA 143 + +++ L ++VME ++ V ++ ++++ + +L + +LH+ Sbjct: 107 MYSSYLVGDEL------WVVMEFLEGGALTDIVTHTRMNEEQIATVCLSVLRALSYLHNQ 160 Query: 144 GIIHRDLKPSNIVVKADCTLKILDFGL-ARTAGTTFMMTPYVVTRYYRAPEVILGMGYTE 202 G+IHRD+K +I++ +D +K+ DFG A+ + V T Y+ APEVI + Y Sbjct: 161 GVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGT 220 Query: 203 NVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENRP 262 VDIWS+G ++ EMI G + P M+R++ Sbjct: 221 EVDIWSLGIMVIEMIDGEPPY---------------FNEPPLQAMRRIR----------- 254 Query: 263 RYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEYINV 322 D L P + + + +S R L MLV +P QR + E L H ++ + Sbjct: 255 ------------DSLPPRVKDLH--KVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKL 300 >3KN6-A nrPDB Length = 325 Score = 96.7 bits (239), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 79/324 (24%), Positives = 144/324 (44%), Gaps = 65/324 (20%) Query: 6 HQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHA 65 +QHY +++ D +P+G G+ I + Q A+K +S+ + T Sbjct: 7 YQHYDLDLKD------------KPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQ- 53 Query: 66 KRAYREFKLMKLV-NHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN-LCQVIQMD--L 121 +E +KL H NI+ L F Q + +LVMEL++ L + I+ Sbjct: 54 ----KEITALKLCEGHPNIVKLHEVFHDQLH------TFLVMELLNGGELFERIKKKKHF 103 Query: 122 DHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKAD---CTLKILDFGLARTA--GT 176 SY++ +++ + H+H G++HRDLKP N++ + +KI+DFG AR Sbjct: 104 SETEASYIMRKLVSAVSHMHDVGVVHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDN 163 Query: 177 TFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKII 236 + TP T +Y APE++ GY E+ D+WS+G I+ M+ G V F D Sbjct: 164 QPLKTP-CFTLHYAAPELLNQNGYDESCDLWSLGVILYTMLSGQVPFQSHD--------- 213 Query: 237 EQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNL 296 + L T + + + +SF+ + + + +A++L Sbjct: 214 -----------RSLTCTSAVEIMKKIKKGDFSFE------------GEAWKNVSQEAKDL 250 Query: 297 LSKMLVIDPEQRISVDEALKHEYI 320 + +L +DP +R+ + +E++ Sbjct: 251 IQGLLTVDPNKRLKMSGLRYNEWL 274 >4PDS-A nrPDB Length = 347 Score = 96.3 bits (238), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 79/311 (25%), Positives = 139/311 (44%), Gaps = 64/311 (20%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNA 89 +G GA V A + T + ++K +S+ + + + RE ++++ +NH I+ L Sbjct: 39 VGQGAFATVKKAIERTTGKTFSVKIISKR-KVIGNMDGVTRELEVLQKLNHPRIVRLKGF 97 Query: 90 FTPQRNLEEFQDVYLVMELMDA-NLCQVIQM--DLDHDRMSYLLYQMLCGIKHLHSAGII 146 + E+ + Y+VME + +L + + D + Q+L IK++HS GI Sbjct: 98 Y------EDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSMGIS 151 Query: 147 HRDLKPSNIVVKAD--CTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMG----- 199 HRDLKP NI+++ D +KI FGLA+ G M + T Y APEVI G Sbjct: 152 HRDLKPDNILIEQDDPVLVKITAFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSP 211 Query: 200 --------YTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQ 251 Y+ VD+WS+GC++ ++ G + F G+ +++ +Q+G Sbjct: 212 DEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQ----DQLYKQIG----------- 256 Query: 252 PTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISV 311 R Y ++ R + +AR+ + +L +DP R + Sbjct: 257 ---------RGSY---------------HEGPLKDFRISEEARDFIDSLLQVDPNNRSTA 292 Query: 312 DEALKHEYINV 322 +AL H +I + Sbjct: 293 AKALNHPWIKM 303 >3Q5I-A nrPDB Length = 504 Score = 96.3 bits (238), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 72/233 (30%), Positives = 110/233 (47%), Gaps = 24/233 (10%) Query: 20 IHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRP-FQNVTHA----------KRA 68 I Y +R +GSGA G V + AIK + + F ++ + Sbjct: 34 IGESYFKVRKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYSDDNKNIEKFHEEI 93 Query: 69 YREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN--LCQVI-QMDLDHDR 125 Y E L+K ++H NII L + F ++ YLV E + Q+I + D Sbjct: 94 YNEISLLKSLDHPNIIKLFDVFEDKKYF------YLVTEFYEGGELFEQIINRHKFDECD 147 Query: 126 MSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTL---KILDFGLARTAGTTFMMTP 182 + ++ Q+L GI +LH I+HRD+KP NI+++ +L KI+DFGL+ + + Sbjct: 148 AANIMKQILSGICYLHKHNIVHRDIKPENILLENKNSLLNIKIVDFGLSSFFSKDYKLRD 207 Query: 183 YVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKI 235 + T YY APEV L Y E D+WS G IM ++ G F G + D K+ Sbjct: 208 RLGTAYYIAPEV-LKKKYNEKCDVWSCGVIMYILLCGYPPFGGQNDQDIIKKV 259 >6FYV-A nrPDB Length = 337 Score = 96.3 bits (238), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 96/350 (27%), Positives = 160/350 (45%), Gaps = 53/350 (15%) Query: 8 HYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYD-TITQQNVAIKKLSRPFQNVTHAK 66 H + GD + +RY + +G GA G V D + +VA+K + +NV + Sbjct: 3 HLICQSGDV---LRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIV----KNVGRYR 55 Query: 67 RAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQD---VYLVMELMDANLCQVIQ----- 118 A R ++++ H N + F + LE F V +V EL+ + I+ Sbjct: 56 EAAR--SEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFL 113 Query: 119 -MDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIV-VKAD---------------- 160 +DH R + YQ+ I LH + H DLKP NI+ VK+D Sbjct: 114 PFQIDHIRQ--MAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTL 171 Query: 161 --CTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIR 218 +K++DFG A + V TR+YRAPEVIL +G+++ D+WS+GCI+ E Sbjct: 172 KNTDIKVVDFGSATYDDEHH--STLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYL 229 Query: 219 GGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFD------RL 272 G +F D + ++E++ P P M + + + N+ + +S R Sbjct: 230 GFTVFQTHDSKEHL-AMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRC 288 Query: 273 FPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEYINV 322 P F +++ + +L+ +ML DP QRI++DEAL+H + ++ Sbjct: 289 KPLKEFMLCHDEEHEK----LFDLVRRMLEYDPTQRITLDEALQHPFFDL 334 >6FD3-A nrPDB Length = 300 Score = 95.1 bits (235), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 74/251 (29%), Positives = 120/251 (47%), Gaps = 16/251 (6%) Query: 11 VEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYR 70 V VGD +Y IG GA G V A D T Q VAIK+++ Q + Sbjct: 15 VSVGDP----KKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMN--LQQQPKKELIIN 68 Query: 71 EFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVME-LMDANLCQVI-QMDLDHDRMSY 128 E +M+ + NI+ L+++ L ++VME L +L V+ + +D +++ Sbjct: 69 EILVMRENKNPNIVNYLDSYLVGDEL------WVVMEYLAGGSLTDVVTETCMDEGQIAA 122 Query: 129 LLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGL-ARTAGTTFMMTPYVVTR 187 + + L + LHS +IHRD+K NI++ D ++K+ DFG A+ + V T Sbjct: 123 VCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTP 182 Query: 188 YYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFM 247 Y+ APEV+ Y VDIWS+G + EM+ G + + + +I GTP Sbjct: 183 YWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRAL-YLIATNGTPELQNP 241 Query: 248 QRLQPTVRNYV 258 +RL R+++ Sbjct: 242 ERLSAVFRDFL 252 >3F3Z-A nrPDB Length = 277 Score = 95.1 bits (235), Expect = 5e-20, Method: Compositional matrix adjust. Identities = 90/325 (27%), Positives = 139/325 (42%), Gaps = 58/325 (17%) Query: 14 GDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFK 73 G T I+ Y IG G+ G V A T+ A KK+ + F V R +E + Sbjct: 1 GSTKGDINQYYTLENTIGRGSWGEVKIAVQKGTRIRRAAKKIPKYF--VEDVDRFKQEIE 58 Query: 74 LMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN--LCQVIQMDLDHDR-MSYLL 130 +MK ++H NII L F E+ D+YLVMEL +V+ + + + ++ Sbjct: 59 IMKSLDHPNIIRLYETF------EDNTDIYLVMELCTGGELFERVVHKRVFRESDAARIM 112 Query: 131 YQMLCGIKHLHSAGIIHRDLKPSNIVV---KADCTLKILDFGLARTAGTTFMMTPYVVTR 187 +L + + H + HRDLKP N + D LK++DFGLA MM V T Sbjct: 113 KDVLSAVAYCHKLNVAHRDLKPENFLFLTDSPDSPLKLIDFGLAARFKPGKMMRTKVGTP 172 Query: 188 YYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFM 247 YY +P+V+ G+ Y D WS G +M ++ G F + KI E T Sbjct: 173 YYVSPQVLEGL-YGPECDEWSAGVMMYVLLCGYPPFSAPTDSEVMLKIREGTFT------ 225 Query: 248 QRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQ 307 FP+ + N + Q A +L+ ++L P+Q Sbjct: 226 -------------------------FPEKDWLNVSPQ--------AESLIRRLLTKSPKQ 252 Query: 308 RISVDEALKHEYINVWYDAEEVDAP 332 RI+ +AL+HE W++ + +P Sbjct: 253 RITSLQALEHE----WFEKQLSSSP 273 >3Q53-A nrPDB Length = 306 Score = 94.7 bits (234), Expect = 6e-20, Method: Compositional matrix adjust. Identities = 67/212 (31%), Positives = 106/212 (50%), Gaps = 15/212 (7%) Query: 11 VEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYR 70 V VGD +Y IG GA G V A D T Q VAI++++ Q + Sbjct: 14 VSVGDP----KKKYTRFEKIGQGASGTVYTAMDVATGQEVAIRQMN--LQQQPKKELIIN 67 Query: 71 EFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVME-LMDANLCQVI-QMDLDHDRMSY 128 E +M+ + NI+ L+++ L ++VME L +L V+ + +D +++ Sbjct: 68 EILVMRENKNPNIVNYLDSYLVGDEL------WVVMEYLAGGSLTDVVTETCMDEGQIAA 121 Query: 129 LLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGL-ARTAGTTFMMTPYVVTR 187 + + L ++ LHS +IHRD+K NI++ D ++K+ DFG A+ + V T Sbjct: 122 VCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTP 181 Query: 188 YYRAPEVILGMGYTENVDIWSVGCIMGEMIRG 219 Y+ APEV+ Y VDIWS+G + EMI G Sbjct: 182 YWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEG 213 >4NIF-A nrPDB Length = 333 Score = 94.7 bits (234), Expect = 6e-20, Method: Compositional matrix adjust. Identities = 75/258 (29%), Positives = 124/258 (48%), Gaps = 54/258 (20%) Query: 74 LMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN--LCQVIQMDLDHDR-MSYLL 130 L++ H NII L + + ++ + VYLV ELM L ++++ +R S++L Sbjct: 55 LLRYGQHPNIITLKDVY------DDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVL 108 Query: 131 YQMLCGIKHLHSAGIIHRDLKPSNIVV-----KADCTLKILDFGLART--AGTTFMMTPY 183 + + +++LHS G++HRDLKPSNI+ +C L+I DFG A+ A +MTP Sbjct: 109 HTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPEC-LRICDFGFAKQLRAENGLLMTP- 166 Query: 184 VVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPS 243 T + APEV+ GY E DIWS+G ++ M+ G F D +I+ ++G+ Sbjct: 167 CYTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPS-DTPEEILTRIGS-- 223 Query: 244 PSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVI 303 G F + N + A++L+SKML + Sbjct: 224 --------------------------------GKF-TLSGGNWNTVSETAKDLVSKMLHV 250 Query: 304 DPEQRISVDEALKHEYIN 321 DP QR++ + L+H ++ Sbjct: 251 DPHQRLTAKQVLQHPWVT 268 >4FIE-A nrPDB Length = 423 Score = 94.0 bits (232), Expect = 9e-20, Method: Compositional matrix adjust. Identities = 73/294 (24%), Positives = 131/294 (44%), Gaps = 51/294 (17%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNA 89 IG G+ GIVC A + + VA+KK+ + + + E +M+ H+N++ + N+ Sbjct: 159 IGEGSTGIVCIATVRSSGKLVAVKKMD--LRKQQRRELLFNEVVIMRDYQHENVVEMYNS 216 Query: 90 FTPQRNLEEFQDVYLVMELMDANLCQ--VIQMDLDHDRMSYLLYQMLCGIKHLHSAGIIH 147 + ++++VME ++ V ++ ++++ + +L + LH+ G+IH Sbjct: 217 YL------VGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIH 270 Query: 148 RDLKPSNIVVKADCTLKILDFGL-ARTAGTTFMMTPYVVTRYYRAPEVILGMGYTENVDI 206 RD+K +I++ D +K+ DFG A+ + V T Y+ APE+I + Y VDI Sbjct: 271 RDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDI 330 Query: 207 WSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENRPRYTG 266 WS+G ++ EM+ G P + N P Sbjct: 331 WSLGIMVIEMVDG-----------------------EPPYF------------NEPPLKA 355 Query: 267 YSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEYI 320 R D L P N + + + + L ++LV DP QR + E LKH ++ Sbjct: 356 MKMIR---DNLPPRLKNLH--KVSPSLKGFLDRLLVRDPAQRATAAELLKHPFL 404 >4B6L-A nrPDB Length = 281 Score = 94.0 bits (232), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 79/315 (25%), Positives = 135/315 (42%), Gaps = 62/315 (19%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIK-----KLSRPFQNVTHAKRAYREFKLMKLV 78 Y+ R +G G A DT T A+K ++++P Q ++ E +L + + Sbjct: 11 YLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQR----EKILNEIELHRDL 66 Query: 79 NHKNIIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQM--DLDHDRMSYLLYQMLC 135 H++I+ + F E+ ++Y+ +EL +L + + L + Y L Q+L Sbjct: 67 QHRHIVRFSHHF------EDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILS 120 Query: 136 GIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGL-ARTAGTTFMMTPYVVTRYYRAPEV 194 G+K+LH GI+HRDLK N + + LK+ DFGL AR T Y APEV Sbjct: 121 GLKYLHQRGILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEV 180 Query: 195 ILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTV 254 +L G+ D+WS+GC+M ++ G F D + + + I+Q+ P+ + Sbjct: 181 LLRQGHGPEADVWSLGCVMYTLLCGSPPFETAD-LKETYRCIKQVHYTLPASL------- 232 Query: 255 RNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEA 314 + AR LL+ +L P R S+D+ Sbjct: 233 -----------------------------------SLPARQLLAAILRASPRDRPSIDQI 257 Query: 315 LKHEYINVWYDAEEV 329 L+H++ Y + + Sbjct: 258 LRHDFFTKGYTPDRL 272 >4XBR-A nrPDB Length = 366 Score = 94.0 bits (232), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 75/298 (25%), Positives = 131/298 (43%), Gaps = 51/298 (17%) Query: 26 NLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIG 85 N IG G+ GIVC A + + VA+KK+ + + + E +M+ H+N++ Sbjct: 98 NFIKIGEGSTGIVCIATVRSSGKLVAVKKMD--LRKQQRRELLFNEVVIMRDYQHENVVE 155 Query: 86 LLNAFTPQRNLEEFQDVYLVMELMDANLCQ--VIQMDLDHDRMSYLLYQMLCGIKHLHSA 143 + N++ L ++VME ++ V ++ ++++ + +L + LH+ Sbjct: 156 MYNSYLVGDEL------WVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQ 209 Query: 144 GIIHRDLKPSNIVVKADCTLKILDFGL-ARTAGTTFMMTPYVVTRYYRAPEVILGMGYTE 202 G+IHRD+K +I++ D +K+ DFG A+ + V T Y+ APE+I + Y Sbjct: 210 GVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGP 269 Query: 203 NVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENRP 262 VDIWS+G ++ EM+ G P + N P Sbjct: 270 EVDIWSLGIMVIEMVDG-----------------------EPPYF------------NEP 294 Query: 263 RYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEYI 320 R D L P +N + + + L ++LV DP QR + E LKH ++ Sbjct: 295 PLKAMKMIR---DNLPP--RLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFL 347 >4KS7-A nrPDB Length = 292 Score = 93.6 bits (231), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 76/314 (24%), Positives = 142/314 (45%), Gaps = 55/314 (17%) Query: 10 TVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAY 69 V+ GD + S Y+ IG G+ GIVC A + + + VA+K + + + + Sbjct: 15 VVDQGDPRLLLDS-YVK---IGEGSTGIVCLAREKHSGRQVAVKMMD--LRKQQRRELLF 68 Query: 70 REFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQ--VIQMDLDHDRMS 127 E +M+ H N++ + ++ ++++++ME + V Q+ L+ ++++ Sbjct: 69 NEVVIMRDYQHFNVVEMYKSYLVG------EELWVLMEFLQGGALTDIVSQVRLNEEQIA 122 Query: 128 YLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGL-ARTAGTTFMMTPYVVT 186 + +L + +LH+ G+IHRD+K +I++ D +K+ DFG A+ + V T Sbjct: 123 TVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGT 182 Query: 187 RYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSF 246 Y+ APEVI Y VDIWS+G ++ EM+ G + + Sbjct: 183 PYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQA--------------- 227 Query: 247 MQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPE 306 M+RL+ + P +NS + + R+ L +MLV DP+ Sbjct: 228 MKRLRDS-------------------------PPPKLKNSHKVSPVLRDFLERMLVRDPQ 262 Query: 307 QRISVDEALKHEYI 320 +R + E L H ++ Sbjct: 263 ERATAQELLDHPFL 276 >2Q0N-A nrPDB Length = 301 Score = 93.6 bits (231), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 74/298 (24%), Positives = 132/298 (44%), Gaps = 51/298 (17%) Query: 26 NLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIG 85 N IG G+ GIVC A + + VA+KK+ + + + E +M+ H+N++ Sbjct: 33 NFIKIGEGSTGIVCIATVRSSGKLVAVKKMD--LRKQQRRELLFNEVVIMRDYQHENVVE 90 Query: 86 LLNAFTPQRNLEEFQDVYLVMELMDANLCQ--VIQMDLDHDRMSYLLYQMLCGIKHLHSA 143 + N++ ++++VME ++ V ++ ++++ + +L + LH+ Sbjct: 91 MYNSYL------VGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQ 144 Query: 144 GIIHRDLKPSNIVVKADCTLKILDFGL-ARTAGTTFMMTPYVVTRYYRAPEVILGMGYTE 202 G+IHRD+K +I++ D +K+ DFG A+ + V T Y+ APE+I + Y Sbjct: 145 GVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGP 204 Query: 203 NVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENRP 262 VDIWS+G ++ EM+ G P + N P Sbjct: 205 EVDIWSLGIMVIEMVDG-----------------------EPPYF------------NEP 229 Query: 263 RYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEYI 320 R D L P N + + + + L ++LV DP QR + E LKH ++ Sbjct: 230 PLKAMKMIR---DNLPPRLKNLH--KVSPSLKGFLDRLLVRDPAQRATAAELLKHPFL 282 >4JDH-A nrPDB Length = 346 Score = 93.6 bits (231), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 74/298 (24%), Positives = 132/298 (44%), Gaps = 51/298 (17%) Query: 26 NLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIG 85 N IG G+ GIVC A + + VA+KK+ + + + E +M+ H+N++ Sbjct: 78 NFIKIGEGSTGIVCIATVRSSGKLVAVKKMD--LRKQQRRELLFNEVVIMRDYQHENVVE 135 Query: 86 LLNAFTPQRNLEEFQDVYLVMELMDANLCQ--VIQMDLDHDRMSYLLYQMLCGIKHLHSA 143 + N++ ++++VME ++ V ++ ++++ + +L + LH+ Sbjct: 136 MYNSYL------VGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQ 189 Query: 144 GIIHRDLKPSNIVVKADCTLKILDFGL-ARTAGTTFMMTPYVVTRYYRAPEVILGMGYTE 202 G+IHRD+K +I++ D +K+ DFG A+ + V T Y+ APE+I + Y Sbjct: 190 GVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGP 249 Query: 203 NVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENRP 262 VDIWS+G ++ EM+ G P + N P Sbjct: 250 EVDIWSLGIMVIEMVDG-----------------------EPPYF------------NEP 274 Query: 263 RYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEYI 320 R D L P N + + + + L ++LV DP QR + E LKH ++ Sbjct: 275 PLKAMKMIR---DNLPPRLKNLH--KVSPSLKGFLDRLLVRDPAQRATAAELLKHPFL 327 >6HMD-A nrPDB Length = 365 Score = 93.6 bits (231), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 64/226 (28%), Positives = 116/226 (51%), Gaps = 21/226 (9%) Query: 104 LVMELMD-ANLCQVIQMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-ADC 161 LV E ++ + Q+ Q+ D D + + +Y++L + + HS GI+HRD+KP N+++ Sbjct: 127 LVFEYINNTDFKQLYQILTDFD-IRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQK 185 Query: 162 TLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMG-YTENVDIWSVGCIMGEMI-RG 219 L+++D+GLA V +RY++ PE+++ Y ++D+WS+GC++ MI R Sbjct: 186 KLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRR 245 Query: 220 GVLFPGTDHIDQWNKIIEQLGTPS-----PSFMQRLQPTVRNYVENRPRYTGYSFDRLFP 274 F G D+ DQ +I + LGT + L P + + R +F Sbjct: 246 EPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENF----- 300 Query: 275 DGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEYI 320 +++N + +A +LL K+L D +QR++ EA++H Y Sbjct: 301 ------IHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 340 >4FG9-A nrPDB Length = 320 Score = 92.8 bits (229), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 78/297 (26%), Positives = 136/297 (45%), Gaps = 52/297 (17%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNA 89 +G+GA V A D TQ+ VAIK +++ E ++ + H NI+ L + Sbjct: 26 LGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSME-NEIAVLHKIKHPNIVALDDI 84 Query: 90 FTPQRNLEEFQDVYLVMELMDAN--LCQVIQMDLDHDR-MSYLLYQMLCGIKHLHSAGII 146 + +L YL+M+L+ ++++ +R S L++Q+L +K+LH GI+ Sbjct: 85 YESGGHL------YLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLGIV 138 Query: 147 HRDLKPSNIV---VKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGYTEN 203 HRDLKP N++ + D + I DFGL++ +++ T Y APEV+ Y++ Sbjct: 139 HRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEVLAQKPYSKA 198 Query: 204 VDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENRPR 263 VD WS+G I ++ G P D D K+ EQ+ Sbjct: 199 VDCWSIGVIAYILLCG--YPPFYDENDA--KLFEQILKAE-------------------- 234 Query: 264 YTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEYI 320 Y FD + D + + A++ + ++ DPE+R + ++AL+H +I Sbjct: 235 ---YEFDSPYWDDI------------SDSAKDFIRHLMEKDPEKRFTCEQALQHPWI 276 >2PVN-A nrPDB Length = 352 Score = 92.8 bits (229), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 70/255 (27%), Positives = 120/255 (47%), Gaps = 23/255 (9%) Query: 74 LMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQM 133 L L NI+ LL+ Q + + L+ E ++ +V+ L + Y +Y++ Sbjct: 100 LQNLCGGPNIVKLLDIVRDQHS----KTPSLIFEYVNNTDFKVLYPTLTDYDIRYYIYEL 155 Query: 134 LCGIKHLHSAGIIHRDLKPSNIVVKADC-TLKILDFGLARTAGTTFMMTPYVVTRYYRAP 192 L + + HS GI+HRD+KP N+++ + L+++D+GLA V +RY++ P Sbjct: 156 LKALDYCHSQGIMHRDVKPHNVMIDHELRKLRLIDWGLAEFYHPGKEYNVRVASRYFKGP 215 Query: 193 EVILGM-GYTENVDIWSVGCIMGEMI-RGGVLFPGTDHIDQWNKIIEQLGTPS-----PS 245 E+++ + Y ++D+WS+GC+ MI R F G D+ DQ KI + LGT Sbjct: 216 ELLVDLQDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKIAKVLGTDGLNAYLNK 275 Query: 246 FMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDP 305 + L P + V R F N N + +A + L K+L D Sbjct: 276 YRIELDPQLEALVGRHSRKPWLKF-----------MNADNQHLVSPEAIDFLDKLLRYDH 324 Query: 306 EQRISVDEALKHEYI 320 ++R++ EA+ H Y Sbjct: 325 QERLTALEAMTHPYF 339 >2VZ6-A nrPDB Length = 313 Score = 92.8 bits (229), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 78/315 (24%), Positives = 142/315 (45%), Gaps = 46/315 (14%) Query: 11 VEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYR 70 V++G N S Y +G GA +V + Q A K ++ + ++ R Sbjct: 11 VDLGTENLYFQSMYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLER 70 Query: 71 EFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLL 130 E ++ +L+ H NI+ L ++ + + + D+ EL + + + + D S+ + Sbjct: 71 EARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEAD---ASHCI 127 Query: 131 YQMLCGIKHLHSAGIIHRDLKPSNIVVKAD---CTLKILDFGLA-RTAGTTFMMTPYVVT 186 Q+L + H H G++HRDLKP N+++ + +K+ DFGLA G + T Sbjct: 128 QQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGT 187 Query: 187 RYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSF 246 Y +PEV+ Y + VD+W+ G I+ ++ G +P DQ +++ +Q+ Sbjct: 188 PGYLSPEVLRKDPYGKPVDLWACGVILYILLVG---YPPFWDEDQ-HRLYQQI------- 236 Query: 247 MQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPE 306 + Y F D + P +A++L++KML I+P Sbjct: 237 ----------------KAGAYDFPSPEWDTVTP------------EAKDLINKMLTINPS 268 Query: 307 QRISVDEALKHEYIN 321 +RI+ EALKH +I+ Sbjct: 269 KRITAAEALKHPWIS 283 >5XVU-A nrPDB Length = 332 Score = 92.4 bits (228), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 62/201 (30%), Positives = 110/201 (54%), Gaps = 15/201 (7%) Query: 126 MSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADC-TLKILDFGLARTAGTTFMMTPYV 184 + Y +YQ+L + + HS GI+HRD+KP NI++ + ++++ +GLA V Sbjct: 127 IRYYIYQILKALDYCHSQGIMHRDVKPHNIMIDHENRQIRLISWGLAEFYHPGQEYNVRV 186 Query: 185 VTRYYRAPEVILGMG-YTENVDIWSVGCIMGEMI-RGGVLFPGTDHIDQWNKIIEQLGTP 242 +RYY+ PE+++ + Y ++DIWS+GC++ MI + F G D+ DQ KI + LGT Sbjct: 187 ASRYYKGPELLIDLQLYDYSLDIWSLGCMLAGMIFKKEPFFCGHDNYDQLVKIAKVLGT- 245 Query: 243 SPSFMQRLQPTVRNY-VENRPRYTGY--SFDRLFPDGLFPNDNNQNSRRKASDARNLLSK 299 + L ++ Y ++ +P Y ++R P F +N + + + +L+ K Sbjct: 246 -----EDLHAYLKKYNIKLKPHYLNILGEYERK-PWSHFLTQSNIDIAK--DEVIDLIDK 297 Query: 300 MLVIDPEQRISVDEALKHEYI 320 ML+ D +RI+ EA++H Y Sbjct: 298 MLIYDHAKRIAPKEAMEHPYF 318 >5D9K-A nrPDB Length = 330 Score = 92.4 bits (228), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 72/251 (28%), Positives = 123/251 (49%), Gaps = 17/251 (6%) Query: 22 SRYINLRPIGSGAQG---IVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLV 78 S++ L+ +G G+ G +V + +Q A+K L + V R E ++ V Sbjct: 30 SQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEV 89 Query: 79 NHKNIIGLLNAFTPQRNLEEFQDVYLVMELM-DANLCQVIQMDL--DHDRMSYLLYQMLC 135 NH I+ L AF + L YL+++ + +L + ++ + + + L ++ Sbjct: 90 NHPFIVKLHYAFQTEGKL------YLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELAL 143 Query: 136 GIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTA-GTTFMMTPYVVTRYYRAPEV 194 + HLHS GII+RDLKP NI++ + +K+ DFGL++ + + T Y APEV Sbjct: 144 ALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEV 203 Query: 195 ILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIE-QLGTP---SPSFMQRL 250 + G+T++ D WS G +M EM+ G + F G D + I++ +LG P SP L Sbjct: 204 VNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLL 263 Query: 251 QPTVRNYVENR 261 + + NR Sbjct: 264 RMLFKRNPANR 274 >4D28-A nrPDB Length = 446 Score = 92.0 bits (227), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 69/215 (32%), Positives = 102/215 (47%), Gaps = 14/215 (6%) Query: 28 RPIGSGAQGIVCAAYDTITQQNVAIKKLSRP--FQNVTHAKRAYREFKLMKLVNHKNIIG 85 R IG G V A +T T NVAIK +++ +N + RE +MK+V H NI+ Sbjct: 15 RTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKN-RMVDQIKREISIMKIVRHPNIVR 73 Query: 86 LLNAFTPQRNLEEFQDVYLVMELMDANLC---QVIQMDLDHDRMSYLLYQMLCGIKHLHS 142 L + +Y+V+E + V + L D Q++ + H HS Sbjct: 74 LYEVLASK------SKIYIVLEFVTGGELFDRIVHKGRLKEDESRKYFQQLVDAVAHCHS 127 Query: 143 AGIIHRDLKPSNIVVKADCTLKILDFGL-ARTAGTTFMMTPYVVTRYYRAPEVILGMGYT 201 G+ HRDLKP N+++ + LK+ DFGL A ++ T Y APEV+ G GY Sbjct: 128 KGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLNDTCGTPNYVAPEVLSGQGYD 187 Query: 202 EN-VDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKI 235 + DIWS G I+ ++ G + F TD + KI Sbjct: 188 GSAADIWSCGVILFVILAGYLPFSETDLPGLYRKI 222 >4CFH-A nrPDB Length = 493 Score = 91.7 bits (226), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 83/282 (29%), Positives = 131/282 (46%), Gaps = 31/282 (10%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSR-PFQNVTHAKRAYREFKLMKLVNHKN 82 YI +G G G V +T VA+K L+R +++ + RE + +KL H + Sbjct: 35 YILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPH 94 Query: 83 IIGLLNAF-TPQRNLEEFQDVYLVMELMDAN-----LCQVIQMDLDHDRMSYLLYQMLCG 136 II L TP D+++VME + +C+ ++D R L Q+L G Sbjct: 95 IIKLYQVISTPS-------DIFMVMEYVSGGELFDYICKNGRLDEKESRR--LFQQILSG 145 Query: 137 IKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVIL 196 + + H ++HRDLKP N+++ A KI DFGL+ + + Y APEVI Sbjct: 146 VDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVIS 205 Query: 197 GMGYT-ENVDIWSVGCIMGEMIRGGVLFPGTDHIDQ-WNKIIEQLG-TP---SPSFMQRL 250 G Y VDIWS G I+ ++ G + F DH+ + KI + + TP +PS + L Sbjct: 206 GRLYAGPEVDIWSSGVILYALLCGTLPF-DDDHVPTLFKKICDGIFYTPQYLNPSVISLL 264 Query: 251 Q------PTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNS 286 + P R +++ + + D P LFP D + +S Sbjct: 265 KHMLQVDPMKRATIKDIREHEWFKQD--LPKYLFPEDPSYSS 304 >4REW-A nrPDB Length = 540 Score = 91.7 bits (226), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 83/282 (29%), Positives = 131/282 (46%), Gaps = 31/282 (10%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSR-PFQNVTHAKRAYREFKLMKLVNHKN 82 YI +G G G V +T VA+K L+R +++ + RE + +KL H + Sbjct: 8 YILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPH 67 Query: 83 IIGLLNAF-TPQRNLEEFQDVYLVMELMDAN-----LCQVIQMDLDHDRMSYLLYQMLCG 136 II L TP D+++VME + +C+ ++D R L Q+L G Sbjct: 68 IIKLYQVISTPS-------DIFMVMEYVSGGELFDYICKNGRLDEKESRR--LFQQILSG 118 Query: 137 IKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVIL 196 + + H ++HRDLKP N+++ A KI DFGL+ + + Y APEVI Sbjct: 119 VDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVIS 178 Query: 197 GMGYT-ENVDIWSVGCIMGEMIRGGVLFPGTDHIDQ-WNKIIEQLG-TP---SPSFMQRL 250 G Y VDIWS G I+ ++ G + F DH+ + KI + + TP +PS + L Sbjct: 179 GRLYAGPEVDIWSSGVILYALLCGTLPF-DDDHVPTLFKKICDGIFYTPQYLNPSVISLL 237 Query: 251 Q------PTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNS 286 + P R +++ + + D P LFP D + +S Sbjct: 238 KHMLQVDPMKRASIKDIREHEWFKQD--LPKYLFPEDPSYSS 277 >4JG6-A nrPDB Length = 355 Score = 91.3 bits (225), Expect = 6e-19, Method: Compositional matrix adjust. Identities = 85/318 (26%), Positives = 142/318 (44%), Gaps = 64/318 (20%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNA 89 IG G+ + T A+K + + ++ T L++ H NII L + Sbjct: 43 IGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEI-----LLRYGQHPNIITLKDV 97 Query: 90 FTPQRNLEEFQDVYLVMELMDAN--LCQVIQMDLDHDR-MSYLLYQMLCGIKHLHSAGII 146 + ++ + VY+V ELM L ++++ +R S +L+ + +++LH+ G++ Sbjct: 98 Y------DDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVV 151 Query: 147 HRDLKPSNIVVKADC----TLKILDFGLART--AGTTFMMTPYVVTRYYRAPEVILGMGY 200 HRDLKPSNI+ + +++I DFG A+ A +MTP T + APEV+ GY Sbjct: 152 HRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTP-CYTANFVAPEVLERQGY 210 Query: 201 TENVDIWSVGCIMGEMIRGGVLFP-GTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVE 259 DIWS+G ++ M+ G F G D D +I+ ++G+ S Sbjct: 211 DAACDIWSLGVLLYTMLTGYTPFANGPD--DTPEEILARIGSGKFSL------------- 255 Query: 260 NRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEY 319 G + N + A++L+SKML +DP QR++ L+H + Sbjct: 256 ---------------SGGYWNSVSDT-------AKDLVSKMLHVDPHQRLTAALVLRHPW 293 Query: 320 INVW-----YDAEEVDAP 332 I W Y DAP Sbjct: 294 IVHWDQLPQYQLNRQDAP 311 >3IS5-A nrPDB Length = 285 Score = 90.9 bits (224), Expect = 7e-19, Method: Compositional matrix adjust. Identities = 84/313 (26%), Positives = 134/313 (42%), Gaps = 58/313 (18%) Query: 19 TIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLV 78 TI +I R +GSGA G V + + IK +++ V ++ E +++K + Sbjct: 19 TIDDLFIFKRKLGSGAFGDVHLVEERSSGLERVIKTINKDRSQVP-MEQIEAEIEVLKSL 77 Query: 79 NHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN-------LCQVIQMDLDHDRMSYLLY 131 +H NII + F E++ ++Y+VME + Q L ++ L+ Sbjct: 78 DHPNIIKIFEVF------EDYHNMYIVMETCEGGELLERIVSAQARGKALSEGYVAELMK 131 Query: 132 QMLCGIKHLHSAGIIHRDLKPSNIVVK---ADCTLKILDFGLARTAGTTFMMTPYVVTRY 188 QM+ + + HS ++H+DLKP NI+ + +KI+DFGLA + T T Sbjct: 132 QMMNALAYFHSQHVVHKDLKPENILFQDTSPHSPIKIIDFGLAELFKSDEHSTNAAGTAL 191 Query: 189 YRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQ 248 Y APEV T DIWS G +M ++ G + F GT ++ ++ P++ Sbjct: 192 YMAPEV-FKRDVTFKCDIWSAGVVMYFLLTGCLPFTGTS----LEEVQQKATYKEPNYA- 245 Query: 249 RLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQR 308 VE RP L P A +LL +ML DPE+R Sbjct: 246 ---------VECRP--------------LTPQ------------AVDLLKQMLTKDPERR 270 Query: 309 ISVDEALKHEYIN 321 S + L HE+ Sbjct: 271 PSAAQVLHHEWFK 283 >3BHH-A nrPDB Length = 295 Score = 90.5 bits (223), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 75/295 (25%), Positives = 131/295 (44%), Gaps = 46/295 (15%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNA 89 IG GA +V T A K ++ + ++ RE ++ +L+ H NI+ L ++ Sbjct: 12 IGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNIVRLHDS 71 Query: 90 FTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRD 149 + + D+ EL + + + + D S+ + Q+L + H H G++HRD Sbjct: 72 ISEEGFHYLVFDLVTGGELFEDIVAREYYSEAD---ASHCIQQILEAVLHCHQMGVVHRD 128 Query: 150 LKPSNIVVKADC---TLKILDFGLA-RTAGTTFMMTPYVVTRYYRAPEVILGMGYTENVD 205 LKP N+++ + C +K+ DFGLA G + T Y +PEV+ Y + VD Sbjct: 129 LKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAYGKPVD 188 Query: 206 IWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENRPRYT 265 IW+ G I+ ++ G F D +K+ +Q+ + Sbjct: 189 IWACGVILYILLVGYPPFWDEDQ----HKLYQQI-----------------------KAG 221 Query: 266 GYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEYI 320 Y F D + P +A+NL+++ML I+P +RI+ EALKH ++ Sbjct: 222 AYDFPSPEWDTVTP------------EAKNLINQMLTINPAKRITAHEALKHPWV 264 >2Z7Q-A nrPDB Length = 321 Score = 90.1 bits (222), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 66/229 (28%), Positives = 112/229 (48%), Gaps = 14/229 (6%) Query: 22 SRYINLRPIGSGAQGIVCAAYDTITQQN---VAIKKLSRPFQNVTHAKRAYREFKLMKLV 78 S + L+ +G G+ G V + A+K L + V R E ++ V Sbjct: 28 SHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADV 87 Query: 79 NHKNIIGLLNAFTPQRNLEEFQDVYLVMELM-DANLCQVIQMDL--DHDRMSYLLYQMLC 135 NH ++ L AF + L YL+++ + +L + ++ + + + L ++ Sbjct: 88 NHPFVVKLHYAFQTEGKL------YLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELAL 141 Query: 136 GIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTA-GTTFMMTPYVVTRYYRAPEV 194 G+ HLHS GII+RDLKP NI++ + +K+ DFGL++ A + T Y APEV Sbjct: 142 GLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEV 201 Query: 195 ILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIE-QLGTP 242 + G++ + D WS G +M EM+ G + F G D + I++ +LG P Sbjct: 202 VNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMP 250 >6QAU-A nrPDB Length = 280 Score = 89.7 bits (221), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 63/204 (30%), Positives = 103/204 (50%), Gaps = 22/204 (10%) Query: 30 IGSGAQGIVCAA-YDTITQQNVAIKKLSRPFQNVTHAKRAY-REFKLMKLVNHKNIIGLL 87 +G GA +V + T VAIK +++ +N++ ++ +E K++K + H+NI+ L Sbjct: 19 VGHGAFAVVFRGRHRQKTDWEVAIKSINK--KNLSKSQILLGKEIKILKELQHENIVALY 76 Query: 88 NAFTPQRNLEEFQDVYLVMELMDA-NLCQVIQMD--LDHDRMSYLLYQMLCGIKHLHSAG 144 + E V+LVME + +L +Q L D + L+Q+ ++ LHS G Sbjct: 77 DV------QELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRILHSKG 130 Query: 145 IIHRDLKPSNIVVK---------ADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVI 195 IIHRDLKP NI++ + +KI DFG AR + M + Y APEVI Sbjct: 131 IIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAADLCGSPMYMAPEVI 190 Query: 196 LGMGYTENVDIWSVGCIMGEMIRG 219 + Y D+WS+G ++ + + G Sbjct: 191 MSQHYDAKADLWSIGTVIYQCLVG 214 >3RAW-A nrPDB Length = 381 Score = 89.7 bits (221), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 90/359 (25%), Positives = 148/359 (41%), Gaps = 75/359 (20%) Query: 8 HYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKR 67 H +GD + RY + +G G G V D ++ K+ R NV + Sbjct: 40 HLVCRIGDW---LQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIR---NVGKYRE 93 Query: 68 AYR-EFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMD------ 120 A R E ++K + K+ + + EL+ N + ++ + Sbjct: 94 AARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYP 153 Query: 121 LDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVV-----------KADC-------- 161 L H R ++ YQ+ ++ LH + H DLKP NI+ C Sbjct: 154 LPHVR--HMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNT 211 Query: 162 TLKILDFGLARTAGTTF---MMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIR 218 ++++ DFG A TF T V TR+YR PEVIL +G+ + D+WS+GCI+ E R Sbjct: 212 SIRVADFGSA-----TFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYR 266 Query: 219 GGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLF 278 G LF ++ + ++E++ P PS M +R R Y + GL Sbjct: 267 GFTLFQTHENREHL-VMMEKILGPIPSHMI-----------HRTRKQKY----FYKGGLV 310 Query: 279 PNDNNQNSRRKASDAR-----------------NLLSKMLVIDPEQRISVDEALKHEYI 320 ++N+ + R + + +L+ +ML DP QRI++ EAL H + Sbjct: 311 WDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFF 369 >6EII-A nrPDB Length = 352 Score = 89.7 bits (221), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 62/226 (27%), Positives = 118/226 (52%), Gaps = 21/226 (9%) Query: 104 LVME-LMDANLCQVIQMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADC- 161 LV E + + + Q+ Q D+D + + +Y++L + + HS GI+HRD+KP N+++ + Sbjct: 134 LVFEHVNNTDFKQLYQTLTDYD-IRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHR 192 Query: 162 TLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMG-YTENVDIWSVGCIMGEMI-RG 219 L+++D+GLA V +RY++ PE+++ Y ++D+WS+GC++ MI R Sbjct: 193 KLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRK 252 Query: 220 GVLFPGTDHIDQWNKIIEQLGTPS-----PSFMQRLQPTVRNYVENRPRYTGYSFDRLFP 274 F G D+ DQ +I + LGT + L P + + R++ ++R Sbjct: 253 EPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDIL---GRHSRKRWERFV- 308 Query: 275 DGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEYI 320 +++N + +A + L K+L D + R++ EA++H Y Sbjct: 309 -------HSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 347 >6E2O-A nrPDB Length = 295 Score = 89.4 bits (220), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 61/194 (31%), Positives = 97/194 (50%), Gaps = 6/194 (3%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNA 89 +G G GIV A D Q +AIK++ P ++ +++ + E L K + HKNI+ L + Sbjct: 30 LGKGTYGIVYAGRDLSNQVRIAIKEI--PERDSRYSQPLHEEIALHKHLKHKNIVQYLGS 87 Query: 90 FTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRD 149 F+ ++ F + L + + + + + Q+L G+K+LH I+HRD Sbjct: 88 FSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRD 147 Query: 150 LKPSNIVVKA-DCTLKILDFGLA-RTAGTTFMMTPYVVTRYYRAPEVI--LGMGYTENVD 205 +K N+++ LKI DFG + R AG + T Y APE+I GY + D Sbjct: 148 IKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAAD 207 Query: 206 IWSVGCIMGEMIRG 219 IWS+GC + EM G Sbjct: 208 IWSLGCTIIEMATG 221 >2V7O-A nrPDB Length = 336 Score = 89.0 bits (219), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 74/295 (25%), Positives = 133/295 (45%), Gaps = 46/295 (15%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNA 89 +G GA +V Q A K ++ + ++ RE ++ +L+ H NI+ L ++ Sbjct: 39 LGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDS 98 Query: 90 FTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRD 149 + + D+ EL + + + + D S+ ++Q+L + H+H I+HRD Sbjct: 99 ISEEGFHYLVFDLVTGGELFEDIVAREYYSEAD---ASHCIHQILESVNHIHQHDIVHRD 155 Query: 150 LKPSNIVVKADC---TLKILDFGLA-RTAGTTFMMTPYVVTRYYRAPEVILGMGYTENVD 205 LKP N+++ + C +K+ DFGLA G + T Y +PEV+ Y + VD Sbjct: 156 LKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVD 215 Query: 206 IWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENRPRYT 265 IW+ G I+ ++ G F D +K+ +Q+ + Sbjct: 216 IWACGVILYILLVGYPPFWDEDQ----HKLYQQI-----------------------KAG 248 Query: 266 GYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEYI 320 Y F D + P +A+NL+++ML I+P +RI+ D+ALKH ++ Sbjct: 249 AYDFPSPEWDTVTP------------EAKNLINQMLTINPAKRITADQALKHPWV 291 >4APC-A nrPDB Length = 350 Score = 89.0 bits (219), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 58/214 (27%), Positives = 104/214 (48%), Gaps = 14/214 (6%) Query: 11 VEVGDTNFTIHS--RYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRA 68 V++G N S +Y+ L+ IG G+ G T + IK+++ + + + Sbjct: 11 VDLGTENLYFQSMEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREES 70 Query: 69 YREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDA-NLCQVIQMD----LDH 123 RE ++ + H NI+ +F EE +Y+VM+ + +L + I Sbjct: 71 RREVAVLANMKHPNIVQYRESF------EENGSLYIVMDYCEGGDLFKRINAQKGVLFQE 124 Query: 124 DRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPY 183 D++ Q+ +KH+H I+HRD+K NI + D T+++ DFG+AR +T + Sbjct: 125 DQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARA 184 Query: 184 VV-TRYYRAPEVILGMGYTENVDIWSVGCIMGEM 216 + T YY +PE+ Y DIW++GC++ E+ Sbjct: 185 CIGTPYYLSPEICENKPYNNKSDIWALGCVLYEL 218 >4I6B-A nrPDB Length = 308 Score = 89.0 bits (219), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 75/322 (23%), Positives = 139/322 (43%), Gaps = 62/322 (19%) Query: 19 TIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIK-----KLSRPFQNVTHAKRAYREFK 73 T RY + +G G D + A K ++S+P Q ++ +E + Sbjct: 25 TTGKRYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQR----EKIDKEIE 80 Query: 74 LMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDA-NLCQVIQMD--LDHDRMSYLL 130 L ++++HK+++ + F E+ +++Y+++E ++ +++ L + Y L Sbjct: 81 LHRILHHKHVVQFYHYF------EDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYL 134 Query: 131 YQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGL-ARTAGTTFMMTPYVVTRYY 189 Q++ G+K+LH I+HRDLK N + LK+ DFGL AR T Y Sbjct: 135 RQIVSGLKYLHEQEILHRDLKLGNFFINESMELKVGDFGLAARLEPLEHRRRTICGTPNY 194 Query: 190 RAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQR 249 +PEV+ G+ DIW++GC+M M+ G F T+ + + I E Sbjct: 195 LSPEVLNKQGHGAESDIWALGCVMYTMLLGRPPFETTNLKETYRSIREA----------- 243 Query: 250 LQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRI 309 RYT P L + A++L++ ML +PE R Sbjct: 244 -------------RYT-------MPSSLL------------APAKHLIASMLSKNPEDRP 271 Query: 310 SVDEALKHEYINVWYDAEEVDA 331 S+D+ ++H++ + + + + Sbjct: 272 SLDDIIRHDFFTQGFTPDRLSS 293 >4RED-A nrPDB Length = 351 Score = 88.6 bits (218), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 82/277 (29%), Positives = 128/277 (46%), Gaps = 31/277 (11%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSR-PFQNVTHAKRAYREFKLMKLVNHKN 82 YI +G G G V +T VA+K L+R +++ + RE + +KL H + Sbjct: 16 YILGDTLGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPH 75 Query: 83 IIGLLNAF-TPQRNLEEFQDVYLVMELMDAN-----LCQVIQMDLDHDRMSYLLYQMLCG 136 II L TP D+++VME + +C+ ++D R L Q+L G Sbjct: 76 IIKLYQVISTPS-------DIFMVMEYVSGGELFDYICKNGRLDEKESRR--LFQQILSG 126 Query: 137 IKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVIL 196 + + H ++HRDLKP N+++ A KI DFGL+ + + Y APEVI Sbjct: 127 VDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVIS 186 Query: 197 GMGYT-ENVDIWSVGCIMGEMIRGGVLFPGTDHIDQ-WNKIIEQLG-TP---SPSFMQRL 250 G Y VDIWS G I+ ++ G + F DH+ + KI + + TP +PS + L Sbjct: 187 GRLYAGPEVDIWSSGVILYALLCGTLPF-DDDHVPTLFKKICDGIFYTPQYLNPSVISLL 245 Query: 251 Q------PTVRNYVENRPRYTGYSFDRLFPDGLFPND 281 + P R +++ + + D P LFP D Sbjct: 246 KHMLQVDPMKRASIKDIREHEWFKQD--LPKYLFPED 280 >5JZN-A nrPDB Length = 280 Score = 88.2 bits (217), Expect = 5e-18, Method: Compositional matrix adjust. Identities = 93/327 (28%), Positives = 145/327 (44%), Gaps = 69/327 (21%) Query: 12 EVGDTNF----TIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKR 67 EV + F TI RY R IG G +V + T + A+K + + + Sbjct: 5 EVSEEGFQIPATITERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKS-KCRGKEHM 63 Query: 68 AYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDA-NLCQVIQMDLDHDR- 125 E +++ V H NI+ L+ ++ ++YLVMEL+ +L I + Sbjct: 64 IQNEVSILRRVKHPNIVLLI------EEMDVPTELYLVMELVKGGDLFDAITSTNKYTER 117 Query: 126 -MSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVV----KADCTLKILDFGLARTAGTTFMM 180 S +LY + IK+LHS I+HRD+KP N++V +LK+ DFGLA T + Sbjct: 118 DASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLA-----TIVD 172 Query: 181 TP-YVV--TRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGT--DHIDQWNKI 235 P Y V T Y APE+I GY VDIW+ G I ++ G F G+ D +++I Sbjct: 173 GPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQI 232 Query: 236 I-EQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDAR 294 + Q+ PSP + DN +S A+ Sbjct: 233 LMGQVDFPSPYW----------------------------------DNVSDS------AK 252 Query: 295 NLLSKMLVIDPEQRISVDEALKHEYIN 321 L++ ML++D +QR S + L+H ++N Sbjct: 253 ELITMMLLVDVDQRFSAVQVLEHPWVN 279 >4MD7-E nrPDB Length = 391 Score = 88.2 bits (217), Expect = 5e-18, Method: Compositional matrix adjust. Identities = 64/229 (27%), Positives = 120/229 (52%), Gaps = 27/229 (11%) Query: 104 LVME-LMDANLCQVIQMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADC- 161 LV E + + + Q+ Q D+D + + +Y++L + + HS GI+HRD+KP N+++ + Sbjct: 111 LVFEHVNNTDFKQLYQTLTDYD-IRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHR 169 Query: 162 TLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMG-YTENVDIWSVGCIMGEMI-RG 219 L+++D+GLA V +RY++ PE+++ Y ++D+WS+GC++ MI R Sbjct: 170 KLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRK 229 Query: 220 GVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNY-VENRPRY-------TGYSFDR 271 F G D+ DQ +I + LGT + L + Y +E PR+ + ++R Sbjct: 230 EPFFHGHDNYDQLVRIAKVLGT------EDLYDYIDKYNIELDPRFNDILGRHSRKRWER 283 Query: 272 LFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEYI 320 +++N + +A + L K+L D + R++ EA++H Y Sbjct: 284 FV--------HSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 >2WQN-A nrPDB Length = 310 Score = 87.4 bits (215), Expect = 8e-18, Method: Compositional matrix adjust. Identities = 77/239 (32%), Positives = 118/239 (49%), Gaps = 26/239 (10%) Query: 16 TNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRA--YREFK 73 NF I + IG G V A + VA+KK+ + F + RA +E Sbjct: 32 ANFRIEKK------IGRGQFSEVYRAACLLDGVPVALKKV-QIFDLMDAKARADCIKEID 84 Query: 74 LMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDA-NLCQVI-----QMDLDHDRMS 127 L+K +NH N+I +F E ++ +V+EL DA +L ++I Q L +R Sbjct: 85 LLKQLNHPNVIKYYASFI------EDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTV 138 Query: 128 YLLYQMLC-GIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLAR-TAGTTFMMTPYVV 185 + + LC ++H+HS ++HRD+KP+N+ + A +K+ D GL R + T V Sbjct: 139 WKYFVQLCSALEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVG 198 Query: 186 TRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWN--KIIEQLGTP 242 T YY +PE I GY DIWS+GC++ EM F G D ++ ++ K IEQ P Sbjct: 199 TPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYG-DKMNLYSLCKKIEQCDYP 256 >5U6Y-A nrPDB Length = 461 Score = 86.7 bits (213), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 72/296 (24%), Positives = 133/296 (44%), Gaps = 46/296 (15%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNA 89 +G GA +V + Q A K ++ + ++ RE ++ +L+ H NI+ L ++ Sbjct: 8 LGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDS 67 Query: 90 FTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRD 149 + + + D+ EL + + + + D S+ + Q+L + H H G++HRD Sbjct: 68 ISEEGHHYLIFDLVTGGELFEDIVAREYYSEAD---ASHCIQQILEAVLHCHQMGVVHRD 124 Query: 150 LKPSNIVVKAD---CTLKILDFGLA-RTAGTTFMMTPYVVTRYYRAPEVILGMGYTENVD 205 LKP N+++ + +K+ DFGLA G + T Y +PEV+ Y + VD Sbjct: 125 LKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVD 184 Query: 206 IWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENRPRYT 265 +W+ G I+ ++ G F D +++ +Q+ + Sbjct: 185 LWACGVILYILLVGYPPFWDEDQ----HRLYQQI-----------------------KAG 217 Query: 266 GYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEYIN 321 Y F D + P +A++L++KML I+P +RI+ EALKH +I+ Sbjct: 218 AYDFPSPEWDTVTP------------EAKDLINKMLTINPSKRITAAEALKHPWIS 261 >4WNO-A nrPDB Length = 287 Score = 86.7 bits (213), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 69/219 (31%), Positives = 105/219 (47%), Gaps = 30/219 (13%) Query: 30 IGSGAQGIVC-----AAYDTITQQNVAIKKLSRPFQNVTHAKRAY-REFKLMKLVNHKNI 83 IG GA +V AA+D VA+K +++ +N+ ++ +E K++K + H+NI Sbjct: 26 IGHGAFAVVFKGRHRAAHDL----EVAVKCINK--KNLAKSQTLLGKEIKILKELKHENI 79 Query: 84 IGLLNAFTPQRNLEEFQDVYLVMELMDA-NLCQVIQM--DLDHDRMSYLLYQMLCGIKHL 140 + L + F N VYLVME + +L + L D + L Q+ ++ L Sbjct: 80 VALYD-FQEMAN-----SVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLL 133 Query: 141 HSAGIIHRDLKPSNIVVKADCT---------LKILDFGLARTAGTTFMMTPYVVTRYYRA 191 HS GIIHRDLKP NI++ +KI DFG AR + M + Y A Sbjct: 134 HSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMA 193 Query: 192 PEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHID 230 PEVI+ Y D+WS+G I+ + + G F + D Sbjct: 194 PEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQD 232 >4LFI-A nrPDB Length = 374 Score = 86.3 bits (212), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 56/222 (25%), Positives = 112/222 (50%), Gaps = 13/222 (5%) Query: 104 LVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-ADCT 162 LV E +D +++ L + + ++++L + + HS GI+HRD+KP N+++ + Sbjct: 152 LVFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKK 211 Query: 163 LKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMG-YTENVDIWSVGCIMGEMI-RGG 220 L+++D+GLA V +R+++ PE+++ Y ++D+WS G ++ MI + Sbjct: 212 LRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKRE 271 Query: 221 VLFPGTDHIDQWNKIIEQLGTPS-PSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFP 279 F GT + DQ KI++ LGT ++ + + T+ + +Y + R DG Sbjct: 272 PFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDG--- 328 Query: 280 NDNNQNSRRKASDA-RNLLSKMLVIDPEQRISVDEALKHEYI 320 N +D +L+ +L D ++R++ EA+ H + Sbjct: 329 -----NKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWF 365 >4M7I-A nrPDB Length = 299 Score = 86.3 bits (212), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 71/250 (28%), Positives = 118/250 (47%), Gaps = 40/250 (16%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNA 89 +G G G+V A + + N AIK++ P + + K RE K + + H I+ NA Sbjct: 13 LGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREK-VMREVKALAKLEHPGIVRYFNA 71 Query: 90 FTPQRNLEEFQ----DVYLVMELMDANLCQVIQM-DLDHDRMS----------YLLYQML 134 + + E+ Q VYL +++ LC+ + D + R + ++ Q+ Sbjct: 72 WLEKNTTEKLQPSSPKVYLYIQM---QLCRKENLKDWMNGRCTIEERERSVCLHIFLQIA 128 Query: 135 CGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGT----TFMMTPY------- 183 ++ LHS G++HRDLKPSNI D +K+ DFGL ++TP Sbjct: 129 EAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHT 188 Query: 184 --VVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKI--IEQL 239 V T+ Y +PE I G Y+ VDI+S+G I+ E+ L+P + +++ + + L Sbjct: 189 GQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFEL-----LYPFSTQMERVRTLTDVRNL 243 Query: 240 GTPSPSFMQR 249 P P F Q+ Sbjct: 244 KFP-PLFTQK 252 >2W4O-A nrPDB Length = 349 Score = 86.3 bits (212), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 82/299 (27%), Positives = 135/299 (45%), Gaps = 56/299 (18%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYR-EFKLMKLVNHKNIIGLLN 88 +G GA IV TQ+ A+K L + T K+ R E ++ ++H NII L Sbjct: 61 LGRGATSIVYRCKQKGTQKPYALKVLKK-----TVDKKIVRTEIGVLLRLSHPNIIKLKE 115 Query: 89 AFTPQRNLEEFQDVYLVMELMDAN--LCQVIQMDLDHDR-MSYLLYQMLCGIKHLHSAGI 145 F E ++ LV+EL+ ++++ +R + + Q+L + +LH GI Sbjct: 116 IF------ETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGI 169 Query: 146 IHRDLKPSNIVVKA---DCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGYTE 202 +HRDLKP N++ D LKI DFGL++ +M T Y APE++ G Y Sbjct: 170 VHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGP 229 Query: 203 NVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENRP 262 VD+WSVG I ++ G + ++ G FM R R Sbjct: 230 EVDMWSVGIITYILLCG------------FEPFYDERGD---QFMFR-----------RI 263 Query: 263 RYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEYIN 321 Y F + D + N A++L+ K++V+DP++R++ +AL+H ++ Sbjct: 264 LNCEYYFISPWWDEVSLN------------AKDLVRKLIVLDPKKRLTTFQALQHPWVT 310 >4WB7-A nrPDB Length = 405 Score = 85.9 bits (211), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 68/246 (27%), Positives = 119/246 (48%), Gaps = 22/246 (8%) Query: 23 RYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKR---AYREFKLMKLVN 79 ++ ++ +G+G+ G V T + A+K L + Q V K+ E ++++ VN Sbjct: 97 QFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDK--QKVVKLKQIEHTLNEKRILQAVN 154 Query: 80 HKNIIGLLNAFTPQRNLEEFQDVYLVMEL-----MDANLCQVIQMDLDHDRMSYLLYQML 134 ++ L +F NL Y+VME M ++L ++ + H R + Q++ Sbjct: 155 FPFLVKLEFSFKDNSNL------YMVMEYVPGGEMFSHLRRIGRFSEPHAR--FYAAQIV 206 Query: 135 CGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLA-RTAGTTFMMTPYVVTRYYRAPE 193 ++LHS +I+RDLKP N+++ +++ DFG A R G T+ + T Y APE Sbjct: 207 LTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCG---TPEYLAPE 263 Query: 194 VILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPT 253 +IL GY + VD W++G ++ EM G F I + KI+ F L+ Sbjct: 264 IILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDL 323 Query: 254 VRNYVE 259 +RN ++ Sbjct: 324 LRNLLQ 329 >5UNP-A nrPDB Length = 369 Score = 85.9 bits (211), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 66/225 (29%), Positives = 110/225 (48%), Gaps = 40/225 (17%) Query: 125 RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIV-VKADCTL------------------KI 165 ++ ++ +Q+ +K LH + H DLKP NI+ V +D L ++ Sbjct: 139 QVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRV 198 Query: 166 LDFGLARTAGTTF---MMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVL 222 +DFG A TF + V TR+YRAPEVIL +G+++ D+WS+GCI+ E G L Sbjct: 199 VDFGSA-----TFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTL 253 Query: 223 FPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDN 282 F D+ + ++E++ P PS M R + + R +D G + +N Sbjct: 254 FQTHDNREHL-AMMERILGPIPSRMIRKTRKQKYFYRGR-----LDWDENTSAGRYVREN 307 Query: 283 NQNSRRK-ASDAR------NLLSKMLVIDPEQRISVDEALKHEYI 320 + RR S+A +L+ ML +P +R+++ EAL+H + Sbjct: 308 CKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFF 352 >3DLS-A nrPDB Length = 335 Score = 85.5 bits (210), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 61/202 (30%), Positives = 96/202 (47%), Gaps = 17/202 (8%) Query: 23 RYINLRPIGSGAQGIVCAAYDTITQQNVAIK--KLSRPFQNV----THAKRAYREFKLMK 76 +Y + P+GSGA G V A D + V +K K + ++ + E ++ Sbjct: 25 KYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILS 84 Query: 77 LVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMD----LDHDRMSYLLYQ 132 V H NII +L+ F Q + LVME + L +D LD SY+ Q Sbjct: 85 RVEHANIIKVLDIFENQGFFQ------LVMEKHGSGLDLFAFIDRHPRLDEPLASYIFRQ 138 Query: 133 MLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAP 192 ++ + +L IIHRD+K NIV+ D T+K++DFG A + + T Y AP Sbjct: 139 LVSAVGYLRLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAP 198 Query: 193 EVILGMGY-TENVDIWSVGCIM 213 EV++G Y +++WS+G + Sbjct: 199 EVLMGNPYRGPELEMWSLGVTL 220 >3DAK-A nrPDB Length = 290 Score = 85.1 bits (209), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 80/313 (25%), Positives = 135/313 (43%), Gaps = 64/313 (20%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNA 89 IGSGA +V AAY ++ VAIK+++ + T +E + M +H NI+ + Sbjct: 18 IGSGATAVVQAAYCAPKKEKVAIKRINLE-KCQTSMDELLKEIQAMSQCHHPNIVSYYTS 76 Query: 90 FTPQRNLEEFQDVYLVMELMDA-NLCQVIQMD----------LDHDRMSYLLYQMLCGIK 138 F + L +LVM+L+ ++ +I+ LD ++ +L ++L G++ Sbjct: 77 FVVKDEL------WLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEGLE 130 Query: 139 HLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMT------PYVVTRYYRAP 192 +LH G IHRD+K NI++ D +++I DFG++ T +T +V T + AP Sbjct: 131 YLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWMAP 190 Query: 193 EVILGM-GYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQ 251 EV+ + GY DIWS G E+ G + P M LQ Sbjct: 191 EVMEQVRGYDFKADIWSFGITAIELATGAAPY--------------HKYPPMKVLMLTLQ 236 Query: 252 ---PTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQR 308 P++ V+++ Y R ++S L DPE+R Sbjct: 237 NDPPSLETGVQDKEMLKKY----------------------GKSFRKMISLCLQKDPEKR 274 Query: 309 ISVDEALKHEYIN 321 + E L+H++ Sbjct: 275 PTAAELLRHKFFQ 287 >5DYK-A nrPDB Length = 853 Score = 85.1 bits (209), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 66/206 (32%), Positives = 102/206 (49%), Gaps = 9/206 (4%) Query: 28 RPIGSGAQGIVCAAYDTITQQNVAIKKLS-RPFQNVTHAKRAYREFKLMKLVNHKNIIGL 86 R IG G G V + T+ A+K +S R N+ E ++ +H II L Sbjct: 545 RIIGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINLNQQNNIKLEREITAENDHPFIIRL 604 Query: 87 LNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGIKHLHSAGII 146 + F + ++ EL DA + + + L + + L ++ I++LH I+ Sbjct: 605 VRTFKDSKYFYFLTELVTGGELYDA--IRKLGL-LSKSQAQFYLGSIILAIEYLHERNIV 661 Query: 147 HRDLKPSNIVVKADCTLKILDFGLARTA-GTTFMMTPYVVTRYYRAPEVILGMGYTENVD 205 +RDLKP NI++ +K++DFG A+ G + + V T +Y APEVILG GY VD Sbjct: 662 YRDLKPENILLDKQGYVKLIDFGCAKKVQGRAYTL---VGTPHYMAPEVILGKGYGCTVD 718 Query: 206 IWSVGCIMGEMIRGGVLFPGTDHIDQ 231 IW++G + E I G + F G D DQ Sbjct: 719 IWALGICLYEFICGPLPF-GNDEEDQ 743 >4CZT-A nrPDB Length = 464 Score = 85.1 bits (209), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 69/247 (27%), Positives = 110/247 (44%), Gaps = 22/247 (8%) Query: 28 RPIGSGAQGIVCAAYDTITQQNVAIKKLSRP--FQNVTHAKRAYREFKLMKLVNHKNIIG 85 R +G G V A + NVAIK + + +N A + RE MKL+ H N+I Sbjct: 17 RTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIA-QIKREISTMKLIKHPNVIR 75 Query: 86 LLNAFTPQRNLEEFQDVYLVMELMDAN-LCQVIQMD--LDHDRMSYLLYQMLCGIKHLHS 142 + + +Y V+E + L I + L D Q++ + + HS Sbjct: 76 MFEVMASK------TKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHS 129 Query: 143 AGIIHRDLKPSNIVVKADCTLKILDFGLA------RTAGTTFMMTPYVVTRYYRAPEVIL 196 G+ HRDLKP N+++ A+ LK+ DFGL+ R G ++ T Y APEVI Sbjct: 130 RGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDG---LLHTTCGTPNYVAPEVIN 186 Query: 197 GMGY-TENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVR 255 GY D+WS G I+ ++ G + F ++ + KI + T P F + ++ Sbjct: 187 NKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIK 246 Query: 256 NYVENRP 262 ++ P Sbjct: 247 RILDPNP 253 >5N23-A nrPDB Length = 352 Score = 84.3 bits (207), Expect = 7e-17, Method: Compositional matrix adjust. Identities = 70/248 (28%), Positives = 119/248 (47%), Gaps = 25/248 (10%) Query: 23 RYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKR---AYREFKLMKLVN 79 ++ +R +G+G+ G V T + A+K L + Q V K+ E ++ + VN Sbjct: 43 QFERIRTLGTGSFGRVMLVKHKETGNHYAMKILDK--QKVVKLKQIEHTLNEKRIQQAVN 100 Query: 80 HKNIIGLLNAFTPQRNLEEFQDVYLVMEL-----MDANLCQVIQMDLDHDRMSYLLYQML 134 ++ L +F NL Y+V+E M ++L ++ + H R + Q++ Sbjct: 101 FPFLVKLEFSFKDNSNL------YMVLEYAPGGEMFSHLRRIGRFSEPHAR--FYAAQIV 152 Query: 135 CGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLA-RTAGTTFMMTPYVV--TRYYRA 191 ++LHS +I+RDLKP N+++ +K+ DFG A R G TP+ + T Y A Sbjct: 153 LTFEYLHSLDLIYRDLKPENLLIDQQGYIKVADFGFAKRVKGR----TPWTLCGTPEYLA 208 Query: 192 PEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQ 251 PE+IL GY + VD W++G ++ EM G F I + KI+ F L+ Sbjct: 209 PEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLK 268 Query: 252 PTVRNYVE 259 +RN ++ Sbjct: 269 DLLRNLLQ 276 >5YKS-A nrPDB Length = 377 Score = 84.3 bits (207), Expect = 8e-17, Method: Compositional matrix adjust. Identities = 58/198 (29%), Positives = 94/198 (47%), Gaps = 12/198 (6%) Query: 28 RPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLL 87 + +G G +V A T + VA+K + + + ++E + MKLV H NI+ L Sbjct: 41 KTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHPNIVRLY 100 Query: 88 NAFTPQRNLEEFQDVYLVMELMD-ANLCQVI---QMDLDHDRMSYLLYQMLCGIKHLHSA 143 Q L YL++EL D ++ I + L+ D Q++ I + H Sbjct: 101 EVIDTQTKL------YLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKL 154 Query: 144 GIIHRDLKPSNIV-VKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGY-T 201 ++HRDLKP N+V + +K+ DFG + +T + Y APE++LG Y Sbjct: 155 HVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDA 214 Query: 202 ENVDIWSVGCIMGEMIRG 219 VDIWS+G I+ ++ G Sbjct: 215 PAVDIWSLGVILFMLVCG 232 >5F9E-A nrPDB Length = 353 Score = 84.0 bits (206), Expect = 9e-17, Method: Compositional matrix adjust. Identities = 89/337 (26%), Positives = 144/337 (42%), Gaps = 66/337 (19%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTH-AKRAYREFKLMKLV-NHKNIIGLL 87 +G G+ G V A T Q AIK L + + + E +++ L H + + Sbjct: 27 LGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMF 86 Query: 88 NAFTPQRNLEEFQDVYLVMELMDA-NLCQVIQM--DLDHDRMSYLLYQMLCGIKHLHSAG 144 F + NL + VME ++ +L IQ D R ++ +++ G++ LHS G Sbjct: 87 CTFQTKENL------FFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSKG 140 Query: 145 IIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMT-PYVVTRYYRAPEVILGMGYTEN 203 I++RDLK NI++ D +KI DFG+ + T + T Y APE++LG Y + Sbjct: 141 IVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNEFCGTPDYIAPEILLGQKYNHS 200 Query: 204 VDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENRPR 263 VD WS G ++ EM+ G F G D + ++ I R+ Sbjct: 201 VDWWSFGVLLYEMLIGQSPFHGQDEEELFHSI-------------RM------------- 234 Query: 264 YTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKH----EY 319 DN R +A++LL K+ V +PE+R+ V ++ Sbjct: 235 -----------------DNPFYPRWLEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFRE 277 Query: 320 INVWYDAE--EVDAP----APEPYDHSVDEREHTVEQ 350 IN W + E E+D P P+D S ++E E+ Sbjct: 278 IN-WEELERKEIDPPFRPKVKSPFDCSNFDKEFLNEK 313 >5X3F-B nrPDB Length = 393 Score = 84.0 bits (206), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 67/246 (27%), Positives = 119/246 (48%), Gaps = 22/246 (8%) Query: 23 RYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKR---AYREFKLMKLVN 79 ++ ++ +G+G+ G V + + A+K L + Q V K+ E ++++ VN Sbjct: 85 QFDRIKTLGTGSFGRVMLVKHKESGNHYAMKILDK--QKVVKLKQIEHTLNEKRILQAVN 142 Query: 80 HKNIIGLLNAFTPQRNLEEFQDVYLVMEL-----MDANLCQVIQMDLDHDRMSYLLYQML 134 ++ L +F NL Y+VME M ++L ++ + H R + Q++ Sbjct: 143 FPFLVKLEFSFKDNSNL------YMVMEYVAGGEMFSHLRRIGRFSEPHAR--FYAAQIV 194 Query: 135 CGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLA-RTAGTTFMMTPYVVTRYYRAPE 193 ++LHS +I+RDLKP N+++ +++ DFG A R G T+ + T Y APE Sbjct: 195 LTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCG---TPEYLAPE 251 Query: 194 VILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPT 253 +IL GY + VD W++G ++ EM G F I + KI+ F L+ Sbjct: 252 IILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDL 311 Query: 254 VRNYVE 259 +RN ++ Sbjct: 312 LRNLLQ 317 >5FET-A nrPDB Length = 847 Score = 83.6 bits (205), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 70/229 (30%), Positives = 109/229 (47%), Gaps = 12/229 (5%) Query: 6 HQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLS-RPFQNVTH 64 H +++ DT +H R IG G G V + TQ A+K +S R ++ Sbjct: 518 HLEERIKMQDTKVEMHELETE-RIIGRGTFGTVKLVHHKPTQIRYALKCVSKRSIISLNQ 576 Query: 65 AKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDL-DH 123 E ++ +H II L+ F ++ EL DA + ++ L Sbjct: 577 QNNIKLEREITAENDHPFIIRLVRTFKDSNCFYFLTELVTGGELYDA----IRKLGLLSK 632 Query: 124 DRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLART-AGTTFMMTP 182 + + L ++ I++LH I++RDLKP NI++ +K++DFG A+ G + + Sbjct: 633 PQAQFYLGSIILAIEYLHERNIVYRDLKPENILLDKQGYVKLIDFGCAKKIQGRAYTL-- 690 Query: 183 YVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQ 231 V T +Y APEVILG GY VDIW++G + E I G + F G D DQ Sbjct: 691 -VGTPHYMAPEVILGKGYGCTVDIWALGVCLYEFICGPLPF-GNDQEDQ 737 >4C0T-A nrPDB Length = 974 Score = 83.6 bits (205), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 81/336 (24%), Positives = 138/336 (41%), Gaps = 81/336 (24%) Query: 28 RPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRA----YREFKLMKLVNHKNI 83 + +G G+ V A D IT + A+K L + +++ K+ + L +L N + Sbjct: 272 KELGEGSYSTVILATDKITGKQYAVKVLDK--RHIIKEKKVKYVNIEKHALNRLSNRLGV 329 Query: 84 IGLLNAFTPQRNLEEFQDVYLVMELM-DANLCQVIQM--DLDHDRMSYLLYQMLCGIKHL 140 I L F + +L Y V++ + L +I+ L+ + + Q+L IK++ Sbjct: 330 ISLYFTFQDKDSL------YFVLDYASNGELLTLIKRYNTLNEECTRHFGAQILDAIKYM 383 Query: 141 HSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTT----------FMMTPYVVTRYYR 190 H G+IHRDLKP NI++ ++I DFG AR +V T Y Sbjct: 384 HDNGVIHRDLKPENILLDDKMRIQITDFGTARLLEKKNDESEEYPVDVRAKSFVGTAEYV 443 Query: 191 APEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRL 250 +PE++ + D+W+ GCI+ +MI G F T+ + KI +L Sbjct: 444 SPELLENKYCGKPGDVWAFGCIIYQMIAGKPPFKATNEYLTFQKIT------------KL 491 Query: 251 QPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRIS 310 Q ++F FP + R+L+ K+LV+ P +R + Sbjct: 492 Q---------------FAFSAGFPTII----------------RDLIKKILVLQPSRRAT 520 Query: 311 VDEALKH---------EYINVWYDAEEVDAPAPEPY 337 + E KH ++ ++W D P PY Sbjct: 521 IPEIQKHYFFQSVDFKDFDSIWLS----DPPEIGPY 552 >2VN9-A nrPDB Length = 301 Score = 83.2 bits (204), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 74/295 (25%), Positives = 131/295 (44%), Gaps = 46/295 (15%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNA 89 +G GA +V T Q A K ++ + ++ RE ++ +L+ H NI+ L ++ Sbjct: 12 LGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDS 71 Query: 90 FTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRD 149 + + D+ EL + + + + D S+ + Q+L + H H GI+HRD Sbjct: 72 ISEEGFHYLVFDLVTGGELFEDIVAREYYSEAD---ASHCIQQILESVNHCHLNGIVHRD 128 Query: 150 LKPSNIVVKAD---CTLKILDFGLA-RTAGTTFMMTPYVVTRYYRAPEVILGMGYTENVD 205 LKP N+++ + +K+ DFGLA G + T Y +PEV+ Y + VD Sbjct: 129 LKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVD 188 Query: 206 IWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENRPRYT 265 +W+ G I+ ++ G F D +++ +Q+ + Sbjct: 189 MWACGVILYILLVGYPPFWDEDQ----HRLYQQI-----------------------KAG 221 Query: 266 GYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEYI 320 Y F D + P +A++L++KML I+P +RI+ EALKH +I Sbjct: 222 AYDFPSPEWDTVTP------------EAKDLINKMLTINPAKRITASEALKHPWI 264 >2JAM-A nrPDB Length = 304 Score = 82.8 bits (203), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 76/310 (24%), Positives = 138/310 (44%), Gaps = 58/310 (18%) Query: 20 IHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIK--KLSRPFQNVTHAKRAYREFKLMKL 77 I +I + +GSGA V +T + A+K K S F++ + E ++K Sbjct: 7 IRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDSSLE----NEIAVLKK 62 Query: 78 VNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN--LCQVIQMDLDHDR-MSYLLYQML 134 + H+NI+ L + + E YLVM+L+ ++++ + ++ S ++ Q+L Sbjct: 63 IKHENIVTLEDIY------ESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVL 116 Query: 135 CGIKHLHSAGIIHRDLKPSNIVV---KADCTLKILDFGLARTAGTTFMMTPYVVTRYYRA 191 +K+LH GI+HRDLKP N++ + + + I DFGL++ M T T Y A Sbjct: 117 SAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGIMSTA-CGTPGYVA 175 Query: 192 PEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQ 251 PEV+ Y++ VD WS+G I ++ G P F + + Sbjct: 176 PEVLAQKPYSKAVDCWSIGVITYILLCG-----------------------YPPFYEETE 212 Query: 252 PTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISV 311 + ++ Y F+ F D + + A++ + +L DP +R + Sbjct: 213 SKLFEKIKE----GYYEFESPFWDDI------------SESAKDFICHLLEKDPNERYTC 256 Query: 312 DEALKHEYIN 321 ++AL H +I+ Sbjct: 257 EKALSHPWID 266 >4YNZ-A nrPDB Length = 342 Score = 82.8 bits (203), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 71/314 (22%), Positives = 134/314 (42%), Gaps = 62/314 (19%) Query: 28 RPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLL 87 + +G G G+V +T Q VAIK ++R + + + RE ++KL+ H +++ L Sbjct: 16 KTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHVLKLH 75 Query: 88 NAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMS-----YLLYQMLCGIKHLHS 142 + + ++ L YLV+E + ++ + R++ Q++ + HS Sbjct: 76 DVYENKKYL------YLVLEHVSGG--ELFDYLVKKGRLTPKEARKFFRQIISALDFCHS 127 Query: 143 AGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGY-T 201 I HRDLKP N+++ ++I DFG+A ++ + +Y PEVI G Y Sbjct: 128 HSICHRDLKPENLLLDERNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDG 187 Query: 202 ENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENR 261 D+WS G I+ ++ G + F D +++E+ V+ V + Sbjct: 188 RKADVWSCGVILFALLVGALPFDD----DNLRQLLEK---------------VKRGVFHM 228 Query: 262 PRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEYIN 321 P + D ++LL M+ +D +R++++ KH Sbjct: 229 PHFI------------------------PPDCQSLLRGMIEVDAARRLTLEHIQKH---- 260 Query: 322 VWYDAEEVDAPAPE 335 +WY + + P PE Sbjct: 261 IWYIGGK-NEPEPE 273 >3SOA-A nrPDB Length = 444 Score = 82.8 bits (203), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 74/310 (23%), Positives = 136/310 (43%), Gaps = 48/310 (15%) Query: 16 TNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLM 75 T FT Y +G GA +V + Q A ++ + ++ RE ++ Sbjct: 7 TRFT--EEYQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDHQKLEREARIC 64 Query: 76 KLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLC 135 +L+ H NI+ L ++ + + + D+ EL + + + + D S+ + Q+L Sbjct: 65 RLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEAD---ASHCIQQILE 121 Query: 136 GIKHLHSAGIIHRDLKPSNIVVKAD---CTLKILDFGLA-RTAGTTFMMTPYVVTRYYRA 191 + H H G++HR+LKP N+++ + +K+ DFGLA G + T Y + Sbjct: 122 AVLHCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLS 181 Query: 192 PEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQ 251 PEV+ Y + VD+W+ G I+ ++ G F D +++ +Q+ Sbjct: 182 PEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQ----HRLYQQI------------ 225 Query: 252 PTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISV 311 + Y F D + P +A++L++KML I+P +RI+ Sbjct: 226 -----------KAGAYDFPSPEWDTVTP------------EAKDLINKMLTINPSKRITA 262 Query: 312 DEALKHEYIN 321 EALKH +I+ Sbjct: 263 AEALKHPWIS 272 >4OW8-A nrPDB Length = 283 Score = 82.8 bits (203), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 67/230 (29%), Positives = 107/230 (46%), Gaps = 11/230 (4%) Query: 17 NFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYR-EFKLM 75 T+ RY R I +G G V A D + VA+K L F + +R E + Sbjct: 6 GVTLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTT 65 Query: 76 KLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN-----LCQVIQMDLDHDRMSYLL 130 ++NH I + + Q N E + YLVMEL++ L + ++ L H +L Sbjct: 66 AMLNHPGIASVHDYGESQMN-GEGRTAYLVMELVNGEPLNSVLKRTGRLSLRH--ALDML 122 Query: 131 YQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVV--TRY 188 Q ++ H+AG++HRD+KP NI++ +KI DFG+A+ + +V T Sbjct: 123 EQTGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQ 182 Query: 189 YRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQ 238 Y APE LG + D++S+G + E + G F G + K I++ Sbjct: 183 YIAPEQALGHDASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKE 232 >4L42-A nrPDB Length = 346 Score = 82.8 bits (203), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 62/221 (28%), Positives = 104/221 (47%), Gaps = 17/221 (7%) Query: 27 LRPIGSGAQGIVCAAYDTI---TQQNVAIKKLSRPF--QNVTHAKRAYREFKLMKLVNHK 81 LR +G G G V T + A+K L + +N E +++ V H Sbjct: 23 LRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHP 82 Query: 82 NIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLD----HDRMSYLLYQMLCGI 137 I+ L+ AF L YL++E + +Q++ + D + L ++ + Sbjct: 83 FIVDLIYAFQTGGKL------YLILEYLSGGEL-FMQLEREGIFMEDTACFYLAEISMAL 135 Query: 138 KHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMT-PYVVTRYYRAPEVIL 196 HLH GII+RDLKP NI++ +K+ DFGL + + +T + T Y APE+++ Sbjct: 136 GHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILM 195 Query: 197 GMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIE 237 G+ VD WS+G +M +M+ G F G + +KI++ Sbjct: 196 RSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILK 236 >4X3F-A nrPDB Length = 337 Score = 82.8 bits (203), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 67/230 (29%), Positives = 107/230 (46%), Gaps = 11/230 (4%) Query: 17 NFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYR-EFKLM 75 T+ RY R I +G G V A D + VA+K L F + +R E + Sbjct: 7 GVTLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTT 66 Query: 76 KLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN-----LCQVIQMDLDHDRMSYLL 130 ++NH I + + Q N E + YLVMEL++ L + ++ L H +L Sbjct: 67 AMLNHPGIASVHDYGESQMN-GEGRTAYLVMELVNGEPLNSVLKRTGRLSLRH--ALDML 123 Query: 131 YQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVV--TRY 188 Q ++ H+AG++HRD+KP NI++ +KI DFG+A+ + +V T Sbjct: 124 EQTGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQ 183 Query: 189 YRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQ 238 Y APE LG + D++S+G + E + G F G + K I++ Sbjct: 184 YIAPEQALGHDASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKE 233 >2JC6-A nrPDB Length = 334 Score = 82.4 bits (202), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 73/298 (24%), Positives = 137/298 (45%), Gaps = 54/298 (18%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYR-EFKLMKLVNHKNIIGLLN 88 +G+GA V A + T + A+K + P + + + + E +++ + H+NI+ L + Sbjct: 30 LGTGAFSEVVLAEEKATGKLFAVKCI--PKKALKGKESSIENEIAVLRKIKHENIVALED 87 Query: 89 AFTPQRNLEEFQDVYLVMELMDAN--LCQVIQMDLDHDR-MSYLLYQMLCGIKHLHSAGI 145 + +L YLVM+L+ ++++ ++ S L+ Q+L + +LH GI Sbjct: 88 IYESPNHL------YLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGI 141 Query: 146 IHRDLKPSNIVVKA---DCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGYTE 202 +HRDLKP N++ + + + I DFGL++ G +M+ T Y APEV+ Y++ Sbjct: 142 VHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPYSK 201 Query: 203 NVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENRP 262 VD WS+G I ++ G P D D +K+ EQ+ Sbjct: 202 AVDCWSIGVIAYILLCG--YPPFYDEND--SKLFEQILKAE------------------- 238 Query: 263 RYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEYI 320 Y FD + D + + A++ + ++ DP +R + ++A +H +I Sbjct: 239 ----YEFDSPYWDDI------------SDSAKDFIRNLMEKDPNKRYTCEQAARHPWI 280 >4UZD-A nrPDB Length = 287 Score = 82.4 bits (202), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 79/303 (26%), Positives = 130/303 (42%), Gaps = 62/303 (20%) Query: 28 RPIGSGAQGIVCAAYDTITQQNVAIKKLSRP---FQNVTHAKRAYREFKLMKLVNHKNII 84 RP+G G G V A + ++ +A+K L + V H R RE ++ + H NI+ Sbjct: 14 RPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLR--REVEIQSHLRHPNIL 71 Query: 85 GLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQ-----MDLDHDRMSYLLYQMLCGIKH 139 L F + VYL++E A L V + D R + + ++ + + Sbjct: 72 RLYGYF------HDATRVYLILEY--APLGTVYRELQKLSKFDEQRTATYITELANALSY 123 Query: 140 LHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMG 199 HS +IHRD+KP N+++ + LKI DFG + A ++ T T Y PE+I G Sbjct: 124 CHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSS-RRTTLCGTLDYLPPEMIEGRM 182 Query: 200 YTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVE 259 + E VD+WS+G + E + G F + + + +I Sbjct: 183 HDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRI------------------------ 218 Query: 260 NRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEY 319 +R +T FPD + AR+L+S++L +P QR + E L+H + Sbjct: 219 SRVEFT-------FPDFV------------TEGARDLISRLLKHNPSQRPMLREVLEHPW 259 Query: 320 INV 322 I Sbjct: 260 ITA 262 >6B2Q-A nrPDB Length = 317 Score = 82.0 bits (201), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 70/239 (29%), Positives = 111/239 (46%), Gaps = 14/239 (5%) Query: 8 HYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKR 67 H + VG T+ RY R I +G G V A D + VA+K L F + Sbjct: 21 HMSPRVG---VTLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIE 77 Query: 68 AYR-EFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN-----LCQVIQMDL 121 +R E + ++NH I + + Q N E + YLVMEL++ L + ++ L Sbjct: 78 RFRAEARTTAMLNHPGIASVHDYGESQMN-GEGRTAYLVMELVNGEPLNSVLKRTGRLSL 136 Query: 122 DHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMT 181 H +L Q ++ H+AG++HRD+KP NI++ +KI DFG+A+ + Sbjct: 137 RH--ALDMLEQTGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQ 194 Query: 182 PYVV--TRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQ 238 +V T Y APE LG + D++S+G + E + G F G + K I++ Sbjct: 195 TGMVMGTAQYIAPEQALGHDASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKE 253 >5FG8-A nrPDB Length = 285 Score = 82.0 bits (201), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 79/304 (25%), Positives = 135/304 (44%), Gaps = 64/304 (21%) Query: 30 IGSGAQGIV--CAAYDT---ITQQNVAIKKL-SRPFQNVTHAKRAYREFKLMKLVNHKNI 83 +G GA IV C T + + KKL +R FQ + RE ++ + ++H NI Sbjct: 22 LGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLE------REARICRKLHHPNI 75 Query: 84 IGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGIKHLHSA 143 + L ++ + D+ EL + + + + D S+ + Q+L + H H Sbjct: 76 VRLHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEAD---ASHCIQQILESVNHCHQN 132 Query: 144 GIIHRDLKPSNIVVKAD---CTLKILDFGLA-RTAGTTFMMTPYVVTRYYRAPEVILGMG 199 G++HRDLKP N+++ + +K+ DFGLA G + T Y +PEV+ Sbjct: 133 GVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKEP 192 Query: 200 YTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGT---PSPSFMQRLQPTVRN 256 Y ++VDIW+ G I+ ++ G F D +++I + G PSP Sbjct: 193 YGKSVDIWACGVILYILLVGYPPFWDEDQHRLYSQI--KAGAYDYPSP------------ 238 Query: 257 YVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALK 316 +D + P +A+NL+++ML ++P +RI+ EALK Sbjct: 239 -----------EWDTVTP-----------------EAKNLINQMLTVNPNKRITAAEALK 270 Query: 317 HEYI 320 H +I Sbjct: 271 HPWI 274 >2X4F-A nrPDB Length = 373 Score = 82.0 bits (201), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 89/325 (27%), Positives = 141/325 (43%), Gaps = 61/325 (18%) Query: 6 HQHYTVEVGDTN--FTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKL-SRPFQNV 62 H+ T + G N +T+ I +G G G V +T T +A K + +R ++ Sbjct: 75 HRIVTAKQGAVNSFYTVSKTEI----LGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDK 130 Query: 63 THAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN--LCQVIQMD 120 K E +M ++H N+I L +AF E D+ LVME +D ++I Sbjct: 131 EEVKN---EISVMNQLDHANLIQLYDAF------ESKNDIVLVMEYVDGGELFDRIIDES 181 Query: 121 LDHDRMSYLLY--QMLCGIKHLHSAGIIHRDLKPSNIV-VKADCT-LKILDFGLARTAGT 176 + + +L+ Q+ GI+H+H I+H DLKP NI+ V D +KI+DFGLAR Sbjct: 182 YNLTELDTILFMKQICEGIRHMHQMYILHLDLKPENILCVNRDAKQIKIIDFGLARRYKP 241 Query: 177 TFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKII 236 + T + APEV+ + D+WSVG I ++ G F G + + N I+ Sbjct: 242 REKLKVNFGTPEFLAPEVVNYDFVSFPTDMWSVGVIAYMLLSGLSPFLGDNDAETLNNIL 301 Query: 237 EQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNL 296 R +E D F D + +A+ Sbjct: 302 ----------------ACRWDLE----------DEEFQD-------------ISEEAKEF 322 Query: 297 LSKMLVIDPEQRISVDEALKHEYIN 321 +SK+L+ + RIS EALKH +++ Sbjct: 323 ISKLLIKEKSWRISASEALKHPWLS 347 >1ZXE-A nrPDB Length = 303 Score = 82.0 bits (201), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 70/244 (28%), Positives = 121/244 (49%), Gaps = 36/244 (14%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNA 89 +G GA G V A + + + AIKK+ + ++ E L+ +NH+ ++ A Sbjct: 14 LGQGAFGQVVKARNALDSRYYAIKKIRHTEEKLS---TILSEVMLLASLNHQYVVRYYAA 70 Query: 90 FTPQRN-------LEEFQDVYLVMELMD-ANLCQVIQMD-LDHDRMSY--LLYQMLCGIK 138 + +RN +++ +++ ME + L +I + L+ R Y L Q+L + Sbjct: 71 WLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQRDEYWRLFRQILEALS 130 Query: 139 HLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTA---------------GTTFMMTPY 183 ++HS GIIHR+LKP NI + +KI DFGLA+ G++ +T Sbjct: 131 YIHSQGIIHRNLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKLDSQNLPGSSDNLTSA 190 Query: 184 VVTRYYRAPEVILGMG-YTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTP 242 + T Y A EV+ G G Y E +D++S+G I EMI +P + +++ N I+++L + Sbjct: 191 IGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMI-----YPFSTGMERVN-ILKKLRSV 244 Query: 243 SPSF 246 S F Sbjct: 245 SIEF 248 >5IG1-A nrPDB Length = 344 Score = 81.6 bits (200), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 77/299 (25%), Positives = 131/299 (43%), Gaps = 55/299 (18%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNA 89 IG GA V + T + A+K ++ + + RE + + H++I+ + A Sbjct: 25 IGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRSSEINKIKREIGICSSLQHEHIVSMRRA 84 Query: 90 FTPQRNLEEFQDVYLVMELMDAN--LCQVIQMDLDHDR-MSYLLYQMLCGIKHLHSAGII 146 F R+ F YLV E + +++ +++ S ++Q+L ++H HS II Sbjct: 85 F---RDESHF---YLVFEYVSGGELFDEIVTRKFYNEKDASACMHQILSALQHCHSKNII 138 Query: 147 HRDLKPSNIVVKA---DCTLKILDFGLA--RTAGTTFMMTPYVVTRYYRAPEVILGMGYT 201 HRDLKP N+++ + + +KI DFGLA G T+ + T Y +PEVI + Y Sbjct: 139 HRDLKPENLLLASKDPNAPVKITDFGLAVIMEQGPTYF--GFAGTPGYLSPEVIRRVPYD 196 Query: 202 ENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENR 261 VD+W+ G I+ ++ G F DH Q+L ++N Sbjct: 197 TAVDVWACGVILYILLVGYPPFWEEDH-------------------QKLYAQIKN----- 232 Query: 262 PRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEYI 320 Y F D + + A+ L+ ML +P++R +V E L+H +I Sbjct: 233 ---CQYDFPSPEWDSV------------TTAAKELIKAMLEPNPKRRPTVQELLQHPWI 276 >5EZV-A nrPDB Length = 560 Score = 81.6 bits (200), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 74/271 (27%), Positives = 116/271 (42%), Gaps = 31/271 (11%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSR-PFQNVTHAKRAYREFKLMKLVNHKNIIGLLN 88 +G G G V +T VA+K L+R +++ + RE + +KL H +II L Sbjct: 36 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 95 Query: 89 AF-TPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMS-----YLLYQMLCGIKHLHS 142 TP D ++VME + ++ H R+ L Q+L + + H Sbjct: 96 VISTPT-------DFFMVMEYVSGG--ELFDYICKHGRVEEMEARRLFQQILSAVDYCHR 146 Query: 143 AGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGYT- 201 ++HRDLKP N+++ A KI DFGL+ + + Y APEVI G Y Sbjct: 147 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAG 206 Query: 202 ENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQR-----------L 250 VDIWS G I+ ++ G + F +H+ K I P ++ R + Sbjct: 207 PEVDIWSCGVILYALLCGTLPF-DDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQV 265 Query: 251 QPTVRNYVENRPRYTGYSFDRLFPDGLFPND 281 P R +++ + + D P LFP D Sbjct: 266 DPLKRATIKDIREHEWFKQD--LPSYLFPED 294 >4CFF-A nrPDB Length = 571 Score = 81.3 bits (199), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 89/342 (26%), Positives = 137/342 (40%), Gaps = 64/342 (18%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSR-PFQNVTHAKRAYREFKLMKLVNHKNIIGLLN 88 +G G G V +T VA+K L+R +++ + RE + +KL H +II L Sbjct: 41 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 100 Query: 89 AF-TPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMS-----YLLYQMLCGIKHLHS 142 TP D ++VME + ++ H R+ L Q+L + + H Sbjct: 101 VISTPT-------DFFMVMEYVSGG--ELFDYICKHGRVEEMEARRLFQQILSAVDYCHR 151 Query: 143 AGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGYT- 201 ++HRDLKP N+++ A KI DFGL+ + + Y APEVI G Y Sbjct: 152 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAG 211 Query: 202 ENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENR 261 VDIWS G I+ ++ G + F +H+ P+ ++ +R V Sbjct: 212 PEVDIWSCGVILYALLCGTLPF-DDEHV--------------PTLFKK----IRGGVFYI 252 Query: 262 PRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEYIN 321 P Y S LL ML +DP +R ++ + +HE+ Sbjct: 253 PEYLNRS------------------------VATLLMHMLQVDPLKRATIKDIREHEWFK 288 Query: 322 VWYDAEEVDAPAPEPYDHSV--DEREHTVEQWKELIYEEVMD 361 D P YD +V DE V + E EVM+ Sbjct: 289 --QDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMN 328 >6CQF-A nrPDB Length = 297 Score = 81.3 bits (199), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 60/201 (29%), Positives = 99/201 (49%), Gaps = 17/201 (8%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLS-RPFQNVTHAKRAYREFKLMKLVNHKN 82 Y L+ +G G G V A D ++ VA+K + P +V+ ++ E ++K H N Sbjct: 18 YDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQK---EILILKTCRHAN 74 Query: 83 IIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQM---DLDHDRMSYLLYQMLCGIKH 139 I+ ++ Q +++ ME A Q I L ++SY+ ++L G+ + Sbjct: 75 IVAYHGSYL------WLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAY 128 Query: 140 LHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFM-MTPYVVTRYYRAPE---VI 195 LHS IHRD+K +NI++ +++ DFG++ G T ++ T Y+ APE V Sbjct: 129 LHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLAFIGTPYWMAPEVAAVA 188 Query: 196 LGMGYTENVDIWSVGCIMGEM 216 L GY E DIWS+G E+ Sbjct: 189 LKGGYNELCDIWSLGITAIEL 209 >1U5R-A nrPDB Length = 348 Score = 81.3 bits (199), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 64/201 (31%), Positives = 100/201 (49%), Gaps = 24/201 (11%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLS-RPFQNVTHAKRAYREFKLMKLVNHKN 82 + +LR IG G+ G V A D + VAIKK+S Q+ + +E + ++ + H N Sbjct: 56 FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPN 115 Query: 83 IIGLLNAFTPQRNLEEFQDVYLVMELM---DANLCQVIQMDLDHDRMSYLLYQMLCGIKH 139 I + + +LVME ++L +V + L ++ + + L G+ + Sbjct: 116 TIQYRGCYLREHT------AWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLAY 169 Query: 140 LHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTP---YVVTRYYRAPEVIL 196 LHS +IHRD+K NI++ +K+ DFG A +M P +V T Y+ APEVIL Sbjct: 170 LHSHNMIHRDVKAGNILLSEPGLVKLGDFGSAS------IMAPANSFVGTPYWMAPEVIL 223 Query: 197 GMG---YTENVDIWSVG--CI 212 M Y VD+WS+G CI Sbjct: 224 AMDEGQYDGKVDVWSLGITCI 244 >6ED6-A nrPDB Length = 415 Score = 81.3 bits (199), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 65/225 (28%), Positives = 105/225 (46%), Gaps = 17/225 (7%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAY--REFKLMKLVNHK 81 Y ++ IG GA G V +Q+ A+K LS+ F+ + + A+ E +M N Sbjct: 90 YDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSK-FEMIKRSDSAFFWEERDIMAFANSP 148 Query: 82 NIIGLLNAFTPQRNLEEFQDVYLVMELM-DANLCQVIQ-MDLDHDRMSYLLYQMLCGIKH 139 ++ L AF R L Y+VME M +L ++ D+ + +++ + Sbjct: 149 WVVQLFYAFQDDRYL------YMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALDA 202 Query: 140 LHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMM--TPYVVTRYYRAPEVILG 197 +HS G+IHRD+KP N+++ LK+ DFG T M+ V T Y +PEV+ Sbjct: 203 IHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKS 262 Query: 198 MG----YTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQ 238 G Y D WSVG + EM+ G F + ++KI++ Sbjct: 263 QGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDH 307 >3MN3-A nrPDB Length = 271 Score = 81.3 bits (199), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 73/303 (24%), Positives = 127/303 (41%), Gaps = 59/303 (19%) Query: 27 LRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAK-RAYREFKLMKLVNHKNIIG 85 ++ +G G+ G V AY T T Q VA+K +++ + + R RE ++L+ H +II Sbjct: 9 VKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRHPHIIK 68 Query: 86 LLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMS-----YLLYQMLCGIKHL 140 L + + ++ +V+E L I + D+MS Q++ +++ Sbjct: 69 LYDVIKSK------DEIIMVIEYAGNELFDYI---VQRDKMSEQEARRFFQQIISAVEYC 119 Query: 141 HSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGY 200 H I+HRDLKP N+++ +KI DFGL+ + + Y APEVI G Y Sbjct: 120 HRHKIVHRDLKPENLLLDEHLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKLY 179 Query: 201 T-ENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVE 259 VD+WS G I+ M+ + F + L + N V Sbjct: 180 AGPEVDVWSCGVILYVMLCRRLPFDDES-------------------IPVLFKNISNGVY 220 Query: 260 NRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEY 319 P++ + A L+ +ML+++P RIS+ E ++ ++ Sbjct: 221 TLPKFL------------------------SPGAAGLIKRMLIVNPLNRISIHEIMQDDW 256 Query: 320 INV 322 V Sbjct: 257 FKV 259 >4TNB-A nrPDB Length = 590 Score = 81.3 bits (199), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 57/204 (27%), Positives = 97/204 (47%), Gaps = 12/204 (5%) Query: 28 RPIGSGAQGIVCAAYDTITQQNVAIKKLSRP-FQNVTHAKRAYREFKLMKLVNHKNIIGL 86 R +G G G VCA T + A K+L + + A E ++++ VN + ++ L Sbjct: 190 RVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNL 249 Query: 87 LNAFTPQRNLEEFQDVYLVMELMDA-----NLCQVIQMDLDHDRMSYLLYQMLCGIKHLH 141 A+ + L LV+ +M+ ++ + + +R + ++LCG++ LH Sbjct: 250 AYAYETKDAL------CLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLH 303 Query: 142 SAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGYT 201 ++RDLKP NI++ ++I D GLA ++ V T Y APEV+ Y Sbjct: 304 HENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYG 363 Query: 202 ENVDIWSVGCIMGEMIRGGVLFPG 225 + D W +GC++ EMI G F G Sbjct: 364 LSPDYWGLGCLIYEMIEGQSPFRG 387 >3TAC-A nrPDB Length = 361 Score = 81.3 bits (199), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 79/312 (25%), Positives = 135/312 (43%), Gaps = 72/312 (23%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKL------SRPFQNVTHAKRAYREFKLMKLVNHKNI 83 IG G +V + T Q A+K + S P + KR E + ++ H +I Sbjct: 34 IGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKR---EASICHMLKHPHI 90 Query: 84 IGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQMDLDHDRM------SYLLYQMLCG 136 + LL ++ L Y+V E MD A+LC I D + S+ + Q+L Sbjct: 91 VELLETYSSDGML------YMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEA 144 Query: 137 IKHLHSAGIIHRDLKPSNIVVKA---DCTLKILDFGLARTAGTTFMMTP-YVVTRYYRAP 192 +++ H IIHRD+KP +++ + +K+ FG+A G + ++ V T ++ AP Sbjct: 145 LRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFMAP 204 Query: 193 EVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQP 252 EV+ Y + VD+W G I+ ++ G + F GT Sbjct: 205 EVVKREPYGKPVDVWGCGVILFILLSGCLPFYGTK------------------------- 239 Query: 253 TVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRR---KASDARNLLSKMLVIDPEQRI 309 +RLF +G+ N R+ + A++L+ +ML++DP +RI Sbjct: 240 -----------------ERLF-EGIIKGKYKMNPRQWSHISESAKDLVRRMLMLDPAERI 281 Query: 310 SVDEALKHEYIN 321 +V EAL H ++ Sbjct: 282 TVYEALNHPWLK 293 >2GCD-A nrPDB Length = 309 Score = 81.3 bits (199), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 64/201 (31%), Positives = 100/201 (49%), Gaps = 24/201 (11%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLS-RPFQNVTHAKRAYREFKLMKLVNHKN 82 + +LR IG G+ G V A D + VAIKK+S Q+ + +E + ++ + H N Sbjct: 17 FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPN 76 Query: 83 IIGLLNAFTPQRNLEEFQDVYLVMELM---DANLCQVIQMDLDHDRMSYLLYQMLCGIKH 139 I + + +LVME ++L +V + L ++ + + L G+ + Sbjct: 77 TIQYRGCYLREHT------AWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLAY 130 Query: 140 LHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTP---YVVTRYYRAPEVIL 196 LHS +IHRD+K NI++ +K+ DFG A +M P +V T Y+ APEVIL Sbjct: 131 LHSHNMIHRDVKAGNILLSEPGLVKLGDFGSAS------IMAPANSFVGTPYWMAPEVIL 184 Query: 197 GMG---YTENVDIWSVG--CI 212 M Y VD+WS+G CI Sbjct: 185 AMDEGQYDGKVDVWSLGITCI 205 >3D2K-A nrPDB Length = 272 Score = 80.5 bits (197), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 78/303 (25%), Positives = 132/303 (43%), Gaps = 62/303 (20%) Query: 28 RPIGSGAQGIVCAAYDTITQQNVAIKKLSRP---FQNVTHAKRAYREFKLMKLVNHKNII 84 RP+G G G V A + ++ +A+K L + V H R RE ++ + H NI+ Sbjct: 18 RPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVEHQLR--REVEIQSHLRHPNIL 75 Query: 85 GLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQ-----MDLDHDRMSYLLYQMLCGIKH 139 L F + VYL++E A L V + D R + + ++ + + Sbjct: 76 RLYGYF------HDATRVYLILEY--APLGTVYRELQKLSRFDEQRTATYITELANALSY 127 Query: 140 LHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMG 199 HS +IHRD+KP N+++ ++ LKI DFG + A ++ T T Y PE+I G Sbjct: 128 CHSKRVIHRDIKPENLLLGSNGELKIADFGWSVHAPSS-RRTTLCGTLDYLPPEMIEGRM 186 Query: 200 YTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVE 259 + E VD+WS+G + E + G F + + + +I Sbjct: 187 HDEKVDLWSLGVLCYEFLVGMPPFEAHTYQETYRRI------------------------ 222 Query: 260 NRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEY 319 +R +T FPD + AR+L+S++L + QR+++ E L+H + Sbjct: 223 SRVEFT-------FPDFV------------TEGARDLISRLLKHNASQRLTLAEVLEHPW 263 Query: 320 INV 322 I Sbjct: 264 IKA 266 >3NYO-A nrPDB Length = 576 Score = 80.5 bits (197), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 78/290 (26%), Positives = 121/290 (41%), Gaps = 51/290 (17%) Query: 28 RPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKR-AYREFKLMKLVNHKNIIGL 86 R +G G G VCA T + A KKL + + A E ++++ VN + ++ L Sbjct: 190 RVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSL 249 Query: 87 LNAFTPQRNLEEFQDVYLVMELMDAN-----LCQVIQMDLDHDRMSYLLYQMLCGIKHLH 141 A+ + L LV+ LM+ + + Q R + ++ CG++ LH Sbjct: 250 AYAYETKDAL------CLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLH 303 Query: 142 SAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGYT 201 I++RDLKP NI++ ++I D GLA + V T Y APEV+ YT Sbjct: 304 RERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYT 363 Query: 202 ENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENR 261 + D W++GC++ EMI G SP F QR + R VE Sbjct: 364 FSPDWWALGCLLYEMIAGQ----------------------SP-FQQRKKKIKREEVER- 399 Query: 262 PRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISV 311 L + S R + AR+L S++L DP +R+ Sbjct: 400 ---------------LVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGC 434 >4RLP-A nrPDB Length = 288 Score = 80.1 bits (196), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 62/221 (28%), Positives = 104/221 (47%), Gaps = 17/221 (7%) Query: 27 LRPIGSGAQGIVCAAYDTI---TQQNVAIKKLSRPF--QNVTHAKRAYREFKLMKLVNHK 81 LR +G G G V T + A+K L + +N E +++ V H Sbjct: 10 LRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHP 69 Query: 82 NIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLD----HDRMSYLLYQMLCGI 137 I+ L+ AF L YL++E + +Q++ + D + L ++ + Sbjct: 70 FIVDLIYAFQTGGKL------YLILEYLSGGEL-FMQLEREGIFMEDTACFYLAEISMAL 122 Query: 138 KHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMT-PYVVTRYYRAPEVIL 196 HLH GII+RDLKP NI++ +K+ DFGL + + +T + T Y APE+++ Sbjct: 123 GHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILM 182 Query: 197 GMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIE 237 G+ VD WS+G +M +M+ G F G + +KI++ Sbjct: 183 RSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILK 223 >4FR4-A nrPDB Length = 384 Score = 80.1 bits (196), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 53/200 (26%), Positives = 102/200 (51%), Gaps = 13/200 (6%) Query: 27 LRPIGSGAQGIVCAAYDTITQQNVAIKKLSR-PFQNVTHAKRAYREFKLMKLVNHKNIIG 85 LR IG G+ G VC T++ A+K +++ + ++E ++M+ + H ++ Sbjct: 20 LRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQGLEHPFLVN 79 Query: 86 LLNAFTPQRNLEEFQDVYLVMELM-DANLCQVIQMDLDHDRMSYLLY--QMLCGIKHLHS 142 L +F + +D+++V++L+ +L +Q ++ + L+ +++ + +L + Sbjct: 80 LWYSFQDE------EDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELVMALDYLQN 133 Query: 143 AGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVI---LGMG 199 IIHRD+KP NI++ + I DF +A +T T+ Y APE+ G G Sbjct: 134 QRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQITTMAGTKPYMAPEMFSSRKGAG 193 Query: 200 YTENVDIWSVGCIMGEMIRG 219 Y+ VD WS+G E++RG Sbjct: 194 YSFAVDWWSLGVTAYELLRG 213 >6BDL-A nrPDB Length = 347 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 50/173 (28%), Positives = 81/173 (46%), Gaps = 5/173 (2%) Query: 94 RNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLC---GIKHLHSAGIIHRDL 150 R ++ + +Y++ME I D S + C +LHS GII+RDL Sbjct: 102 RTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDL 161 Query: 151 KPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVG 210 KP N+++ K++DFG A+ G + T Y APE+IL G+ + D WS+G Sbjct: 162 KPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLG 221 Query: 211 CIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENRPR 263 +M E++ G F G D + +N I+ G F +++ N ++ R Sbjct: 222 ILMYELLTGSPPFSGPDPMKTYNIILR--GIDMIEFPKKIAKNAANLIKKLCR 272 >4AF3-A nrPDB Length = 292 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 67/234 (28%), Positives = 113/234 (48%), Gaps = 16/234 (6%) Query: 10 TVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRP---FQNVTHAK 66 T ++ +FTI I RP+G G G V A + + VA+K L + + V H Sbjct: 12 TPDILTRHFTIDDFEIG-RPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQL 70 Query: 67 RAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQMD--LDH 123 R RE ++ ++H NI+ L N F +R +YL++E L + +Q D Sbjct: 71 R--REIEIQAHLHHPNILRLYNYFYDRRR------IYLILEYAPRGELYKELQKSCTFDE 122 Query: 124 DRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPY 183 R + ++ ++ + + H +IHRD+KP N+++ LKI DFG + A + T Sbjct: 123 QRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKT-M 181 Query: 184 VVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIE 237 T Y PE+I G + E VD+W +G + E++ G F H + + +I++ Sbjct: 182 CGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVK 235 >3VN9-A nrPDB Length = 340 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 73/255 (28%), Positives = 118/255 (46%), Gaps = 34/255 (13%) Query: 11 VEVGDTNFTIHSRYINLRPI---GSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKR 67 + +G+ NF + + +L PI G GA G+V + Q +A+K++ R N KR Sbjct: 39 ISIGNQNFEVKAD--DLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI-RATVNSQEQKR 95 Query: 68 AYREFKL-MKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLD---- 122 + + M+ V+ + A L DV++ MELMD +L + + +D Sbjct: 96 LLMDLDISMRTVDCPFTVTFYGA------LFREGDVWICMELMDTSLDKFYKQVIDKGQT 149 Query: 123 --HDRMSYLLYQMLCGIKHLHSA-GIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFM 179 D + + ++ ++HLHS +IHRD+KPSN+++ A +K+ DFG++ + Sbjct: 150 IPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVA 209 Query: 180 MTPYVVTRYYRAPEVILG----MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKI 235 T + Y APE I GY+ DIWS+G M E+ + FP D W Sbjct: 210 KTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIEL--AILRFP----YDSWGTP 263 Query: 236 IEQLGT----PSPSF 246 +QL PSP Sbjct: 264 FQQLKQVVEEPSPQL 278 >3HKO-A nrPDB Length = 345 Score = 79.3 bits (194), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 77/303 (25%), Positives = 131/303 (43%), Gaps = 63/303 (20%) Query: 14 GDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQ---NVTHAKRAYR 70 G + + +Y IG G+ G+V A + T+ AIK +++ N +R Sbjct: 18 GGSLLELQKKYHLKGAIGQGSYGVVRVAIENQTRAIRAIKIMNKNKIRQINPKDVERIKT 77 Query: 71 EFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMEL---------------------- 108 E +LMK ++H NI L + E+ Q + LVMEL Sbjct: 78 EVRLMKKLHHPNIARLYEVY------EDEQYICLVMELCHGGHLLDKLNVFIDDSTGKCA 131 Query: 109 MDANLCQV-----------------IQMDLD----HDRMSYLLYQMLCGIKHLHSAGIIH 147 MD Q+ + LD +S ++ Q+ + +LH+ GI H Sbjct: 132 MDVVKTQICPCPECNEEAINGSIHGFRESLDFVQREKLISNIMRQIFSALHYLHNQGICH 191 Query: 148 RDLKPSNIVVKADCT--LKILDFGLAR-----TAGTTFMMTPYVVTRYYRAPEVI--LGM 198 RD+KP N + + + +K++DFGL++ G + MT T Y+ APEV+ Sbjct: 192 RDIKPENFLFSTNKSFEIKLVDFGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEVLNTTNE 251 Query: 199 GYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKII-EQLGTPSPSFMQRLQPTVRNY 257 Y D WS G ++ ++ G V FPG + D ++++ ++L +P++ L P R+ Sbjct: 252 SYGPKCDAWSAGVLLHLLLMGAVPFPGVNDADTISQVLNKKLCFENPNY-NVLSPLARDL 310 Query: 258 VEN 260 + N Sbjct: 311 LSN 313 >3QD2-B nrPDB Length = 332 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 73/270 (27%), Positives = 114/270 (42%), Gaps = 75/270 (27%) Query: 22 SRYI-NLRPI---GSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKL 77 SRY+ + PI G G G+V A + + N AIK++ P + + K RE K + Sbjct: 2 SRYLTDFEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREK-VMREVKALAK 60 Query: 78 VNHKNIIGLLNAF---TPQRNLEEFQDVYLVMEL----------MDANLCQV-------- 116 + H I+ NA+ P++ EE +++L E MDA ++ Sbjct: 61 LEHPGIVRYFNAWLETPPEKWQEEMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFST 120 Query: 117 -----------------IQMDL-------------------DHDRMSYLLYQMLCGIKHL 140 IQM L +H ++ Q+ ++ L Sbjct: 121 KNTVGQLQPSSPKVYLYIQMQLCRKENLKDWMNRRCSLEDREHGVCLHIFIQIAEAVEFL 180 Query: 141 HSAGIIHRDLKPSNIVVKADCTLKILDFGLA----RTAGTTFMMTPY---------VVTR 187 HS G++HRDLKPSNI D +K+ DFGL + ++TP V T+ Sbjct: 181 HSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQVGTK 240 Query: 188 YYRAPEVILGMGYTENVDIWSVGCIMGEMI 217 Y +PE I G Y+ VDI+S+G I+ E++ Sbjct: 241 LYMSPEQIHGNNYSHKVDIFSLGLILFELL 270 >5X5O-A nrPDB Length = 310 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 69/246 (28%), Positives = 116/246 (47%), Gaps = 27/246 (10%) Query: 31 GSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNAF 90 G G+ G V A + VA+KKL + +E +++ +++H+NII Sbjct: 24 GGGSFGSVYRAKWISQDKEVAVKKL----------LKIEKEAEILSVLSHRNIIQFYGVI 73 Query: 91 TPQRN---LEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGIKHLHSAG--- 144 N + E+ + + + +++N + +MD+DH + + G+ +LH Sbjct: 74 LEPPNYGIVTEYASLGSLYDYINSNRSE--EMDMDH--IMTWATDVAKGMHYLHMEAPVK 129 Query: 145 IIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGYTENV 204 +IHRDLK N+V+ AD LKI DFG +R T M+ V T + APEVI + +E Sbjct: 130 VIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMS-LVGTFPWMAPEVIQSLPVSETC 188 Query: 205 DIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQ---LGTPSP---SFMQRLQPTVRNYV 258 D +S G ++ EM+ V F G + + ++E+ L PS SF + L Sbjct: 189 DTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEADA 248 Query: 259 ENRPRY 264 + RP + Sbjct: 249 KKRPSF 254 >3ORZ-A nrPDB Length = 316 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 70/291 (24%), Positives = 121/291 (41%), Gaps = 56/291 (19%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAY--REFKLMKLVNHKNIIGLL 87 +G G+ V A + T + AIK L + + K Y RE +M ++H + L Sbjct: 45 LGEGSFSTVVLARELATSREYAIKILEKR-HIIKENKVPYVTRERDVMSRLDHPFFVKLY 103 Query: 88 NAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLY--QMLCGIKHLHSAGI 145 F L + + + L + I+ D Y +++ +++LH GI Sbjct: 104 FCFQDDEKL-----YFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGI 158 Query: 146 IHRDLKPSNIVVKADCTLKILDFGLART---AGTTFMMTPYVVTRYYRAPEVILGMGYTE 202 IHRDLKP NI++ D ++I DFG A+ +V T Y +PE++ + Sbjct: 159 IHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACK 218 Query: 203 NVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENRP 262 + D+W++GCI+ +++ G F + + KII+ Sbjct: 219 SSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIK------------------------- 253 Query: 263 RYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDE 313 +D FP+ FP AR+L+ K+LV+D +R+ +E Sbjct: 254 ----LEYD--FPEKFFPK------------ARDLVEKLLVLDATKRLGCEE 286 >2BRG-A nrPDB Length = 297 Score = 78.6 bits (192), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 59/197 (29%), Positives = 96/197 (48%), Gaps = 14/197 (7%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNA 89 +G GA G V A + +T++ VA+K + + V + +E + K++NH+N++ Sbjct: 15 LGEGAYGEVQLAVNRVTEEAVAVKIVDMK-RAVDCPENIKKEICINKMLNHENVV----K 69 Query: 90 FTPQRNLEEFQDVYLVMELMDAN-LCQVIQMDLDHDR--MSYLLYQMLCGIKHLHSAGII 146 F R Q YL +E L I+ D+ +Q++ G+ +LH GI Sbjct: 70 FYGHRREGNIQ--YLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGIT 127 Query: 147 HRDLKPSNIVVKADCTLKILDFGLA---RTAGTTFMMTPYVVTRYYRAPEVILGMGY-TE 202 HRD+KP N+++ LKI DFGLA R ++ T Y APE++ + E Sbjct: 128 HRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAE 187 Query: 203 NVDIWSVGCIMGEMIRG 219 VD+WS G ++ M+ G Sbjct: 188 PVDVWSCGIVLTAMLAG 204 >6E9W-A nrPDB Length = 443 Score = 78.2 bits (191), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 64/223 (28%), Positives = 102/223 (45%), Gaps = 17/223 (7%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAY--REFKLMKLVNHK 81 Y ++ IG GA G V T++ A+K LS+ F+ + + A+ E +M N Sbjct: 104 YEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSK-FEMIKRSDSAFFWEERDIMAFANSP 162 Query: 82 NIIGLLNAFTPQRNLEEFQDVYLVMELM-DANLCQVIQ-MDLDHDRMSYLLYQMLCGIKH 139 ++ L AF R L Y+VME M +L ++ D+ + +++ + Sbjct: 163 WVVQLFYAFQDDRYL------YMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDA 216 Query: 140 LHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMM--TPYVVTRYYRAPEVILG 197 +HS G IHRD+KP N+++ LK+ DFG M+ V T Y +PEV+ Sbjct: 217 IHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKS 276 Query: 198 MG----YTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKII 236 G Y D WSVG + EM+ G F + ++KI+ Sbjct: 277 QGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIM 319 >2YZA-A nrPDB Length = 276 Score = 78.2 bits (191), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 61/202 (30%), Positives = 93/202 (46%), Gaps = 17/202 (8%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSR-PFQNVTHAKRAYREFKLMKLVNHKNIIGLLN 88 +G G G V +T VA+K L+R +++ + RE + +KL H +II L Sbjct: 19 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 78 Query: 89 AF-TPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMS-----YLLYQMLCGIKHLHS 142 TP D ++VME + ++ H R+ L Q+L + + H Sbjct: 79 VISTPT-------DFFMVMEYVSGG--ELFDYICKHGRVEEMEARRLFQQILSAVDYCHR 129 Query: 143 AGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGYT- 201 ++HRDLKP N+++ A KI DFGL+ + + Y APEVI G Y Sbjct: 130 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRDSCGSPNYAAPEVISGRLYAG 189 Query: 202 ENVDIWSVGCIMGEMIRGGVLF 223 VDIWS G I+ ++ G + F Sbjct: 190 PEVDIWSCGVILYALLCGTLPF 211 >4B8L-A nrPDB Length = 286 Score = 78.2 bits (191), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 76/318 (23%), Positives = 130/318 (40%), Gaps = 59/318 (18%) Query: 11 VEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRP---FQNVTHAKR 67 E+ FTI I RP+G G G V A + + +A+K L + + V H R Sbjct: 5 AEMPKRKFTIDDFDIG-RPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLR 63 Query: 68 AYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQMD--LDHD 124 RE ++ + H NI+ + N F ++ +YL++E L + +Q D Sbjct: 64 --REIEIQSHLRHPNILRMYNYFHDRKR------IYLMLEFAPRGELYKELQKHGRFDEQ 115 Query: 125 RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYV 184 R + + ++ + + H +IHRD+KP N+++ LKI DFG + A + T Sbjct: 116 RSATFMEELADALHYCHERKVIHRDIKPENLLMGYKGELKIADFGWSVHAPSLRRRT-MC 174 Query: 185 VTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSP 244 T Y PE+I G + E VD+W G + E + G F H + +I+ Sbjct: 175 GTLDYLPPEMIEGKTHDEKVDLWCAGVLCYEFLVGMPPFDSPSHTETHRRIV-------- 226 Query: 245 SFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVID 304 + D FP L + +++L+SK+L Sbjct: 227 -----------------------NVDLKFPPFL------------SDGSKDLISKLLRYH 251 Query: 305 PEQRISVDEALKHEYINV 322 P QR+ + ++H ++ Sbjct: 252 PPQRLPLKGVMEHPWVKA 269 >5TQX-A nrPDB Length = 655 Score = 78.2 bits (191), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 65/205 (31%), Positives = 90/205 (43%), Gaps = 23/205 (11%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNA 89 +G+G G VC +AIK R + + +R E ++MK +NH N++ + Sbjct: 16 LGTGGFGNVCLYQHRELDLKIAIKS-CRLELSTKNRERWCHEIQIMKKLNHANVVKACD- 73 Query: 90 FTPQRNLEEFQDV-YLVMELMDA-----------NLCQVIQMDLDHDRMSYLLYQMLCGI 137 P+ DV L ME N C L ++ LL + GI Sbjct: 74 -VPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCC-----GLKESQILSLLSDIGSGI 127 Query: 138 KHLHSAGIIHRDLKPSNIV---VKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEV 194 ++LH IIHRDLKP NIV V KI+D G A+ + T +V T Y APE+ Sbjct: 128 RYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGELCTEFVGTLQYLAPEL 187 Query: 195 ILGMGYTENVDIWSVGCIMGEMIRG 219 YT VD WS G ++ E I G Sbjct: 188 FENKPYTATVDYWSFGTMVFECIAG 212 >1PHK-A nrPDB Length = 298 Score = 77.8 bits (190), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 84/334 (25%), Positives = 132/334 (39%), Gaps = 72/334 (21%) Query: 19 TIHSRYINLRP---IGSGAQGIVCAAYDTITQQNVAIKKL------SRPFQNVTHAKRA- 68 + H Y N P +G G +V T + A+K + S + V + A Sbjct: 11 STHGFYENYEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQELREAT 70 Query: 69 YREFKLMKLVN-HKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMS 127 +E +++ V+ H NII L + + D+ EL D +V + + ++ Sbjct: 71 LKEVDILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKKGELFDYLTEKVTLSEKETRKIM 130 Query: 128 YLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTR 187 L +++C LH I+HRDLKP NI++ D +K+ DFG + + T Sbjct: 131 RALLEVICA---LHKLNIVHRDLKPENILLDDDMNIKLTDFGFSCQLDPGEKLREVCGTP 187 Query: 188 YYRAPEVI-LGM-----GYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGT 241 Y APE+I M GY + VD+WS G IM ++ G Sbjct: 188 SYLAPEIIECSMNDNHPGYGKEVDMWSTGVIMYTLLAG---------------------- 225 Query: 242 PSPSFMQRLQPTV------RNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARN 295 SP F R Q + NY P + YS ++ Sbjct: 226 -SPPFWHRKQMLMLRMIMSGNYQFGSPEWDDYS----------------------DTVKD 262 Query: 296 LLSKMLVIDPEQRISVDEALKHEYINVWYDAEEV 329 L+S+ LV+ P++R + +EAL H + Y EEV Sbjct: 263 LVSRFLVVQPQKRYTAEEALAHPFFQ-QYVVEEV 295 >1KOA-A nrPDB Length = 491 Score = 77.8 bits (190), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 72/298 (24%), Positives = 124/298 (41%), Gaps = 55/298 (18%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNA 89 +G+GA G+V + T N A K + P ++ R +E + M ++ H ++ L +A Sbjct: 59 LGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKETVR--KEIQTMSVLRHPTLVNLHDA 116 Query: 90 FTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSY-----LLYQMLCGIKHLHSAG 144 F E+ ++ ++ E M D +H++MS + Q+ G+ H+H Sbjct: 117 F------EDDNEMVMIYEFMSGGELFEKVAD-EHNKMSEDEAVEYMRQVCKGLCHMHENN 169 Query: 145 IIHRDLKPSNIV--VKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGYTE 202 +H DLKP NI+ K LK++DFGL + T + APEV G Sbjct: 170 YVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTTGTAEFAAPEVAEGKPVGY 229 Query: 203 NVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENRP 262 D+WSVG + ++ G F G + + T+RN Sbjct: 230 YTDMWSVGVLSYILLSGLSPFGGENDDE----------------------TLRNVK---- 263 Query: 263 RYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEYI 320 S D D F + D ++ + K+L+ DP R+++ +AL+H ++ Sbjct: 264 -----SCDWNMDDSAFSG--------ISEDGKDFIRKLLLADPNTRMTIHQALEHPWL 308 >3COM-A nrPDB Length = 314 Score = 77.4 bits (189), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 58/198 (29%), Positives = 99/198 (50%), Gaps = 15/198 (7%) Query: 27 LRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGL 86 L +G G+ G V A T Q VAIK++ P + + + +E +M+ + +++ Sbjct: 34 LEKLGEGSYGSVYKAIHKETGQIVAIKQV--PVE--SDLQEIIKEISIMQQCDSPHVVKY 89 Query: 87 LNAFTPQRNLEEFQDVYLVMELMDA-NLCQVIQM---DLDHDRMSYLLYQMLCGIKHLHS 142 ++ D+++VME A ++ +I++ L D ++ +L L G+++LH Sbjct: 90 YGSYFKN------TDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHF 143 Query: 143 AGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVV-TRYYRAPEVILGMGYT 201 IHRD+K NI++ + K+ DFG+A T V+ T ++ APEVI +GY Sbjct: 144 MRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYN 203 Query: 202 ENVDIWSVGCIMGEMIRG 219 DIWS+G EM G Sbjct: 204 CVADIWSLGITAIEMAEG 221 >5DBX-A nrPDB Length = 328 Score = 77.4 bits (189), Expect = 9e-15, Method: Compositional matrix adjust. Identities = 81/313 (25%), Positives = 131/313 (41%), Gaps = 64/313 (20%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNA 89 IGSGA +V AA Q+ VAIK+++ + T +E + M +H N++ + Sbjct: 19 IGSGATAVVQAALCKPRQERVAIKRINLE-KCQTSMDELLKEIQAMSQCSHPNVVTYYTS 77 Query: 90 FTPQRNLEEFQDVYLVMELMDA-NLCQVIQMD----------LDHDRMSYLLYQMLCGIK 138 F + L +LVM+L+ ++ +I+ L+ ++ +L ++L G+ Sbjct: 78 FVVKDEL------WLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGLD 131 Query: 139 HLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMT------PYVVTRYYRAP 192 +LH G IHRDLK NI++ D +++I DFG++ T +T +V T + AP Sbjct: 132 YLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKDFVGTPCWMAP 191 Query: 193 EVILGM-GYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQ 251 EV+ + GY D+WS G E+ G + P M LQ Sbjct: 192 EVMEQVRGYDFKADMWSFGITAIELATGAAPY--------------HKYPPMKVLMLTLQ 237 Query: 252 ---PTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQR 308 PT+ VE++ Y R LLS L DP +R Sbjct: 238 NDPPTLETGVEDKEMMKKY----------------------GKSFRKLLSLCLQKDPSKR 275 Query: 309 ISVDEALKHEYIN 321 + E LK ++ Sbjct: 276 PTAAELLKCKFFQ 288 >3UC3-A nrPDB Length = 361 Score = 77.4 bits (189), Expect = 9e-15, Method: Compositional matrix adjust. Identities = 74/300 (24%), Positives = 120/300 (40%), Gaps = 46/300 (15%) Query: 23 RYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKN 82 RY ++ IGSG G+ D +T++ VA+K + R + RE + + H N Sbjct: 21 RYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIER---GAAIDENVQREIINHRSLRHPN 77 Query: 83 IIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGIKHLHS 142 I+ +L + EL + +C + D R + Q+L G+ + HS Sbjct: 78 IVRFKEVILTPTHLAIIMEYASGGELYE-RICNAGRFSEDEAR--FFFQQLLSGVSYCHS 134 Query: 143 AGIIHRDLKPSNIVVKADCT--LKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGY 200 I HRDLK N ++ LKI DFG ++++ V T Y APEV+L Y Sbjct: 135 MQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEY 194 Query: 201 TENV-DIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVE 259 + D+WS G + M+ G F + + K I+++ Sbjct: 195 DGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRI-------------------- 234 Query: 260 NRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEY 319 S PD + R + + +L+S++ V DP RIS+ E H + Sbjct: 235 -------LSVKYSIPDDI----------RISPECCHLISRIFVADPATRISIPEIKTHSW 277 >5H2U-A nrPDB Length = 267 Score = 77.4 bits (189), Expect = 9e-15, Method: Compositional matrix adjust. Identities = 68/226 (30%), Positives = 107/226 (47%), Gaps = 20/226 (8%) Query: 28 RPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLL 87 R +GSG G V Q VAIK +SR N+ H + E + MK + HK+I+ L Sbjct: 12 RKLGSGYFGEVFEGLWKDRVQ-VAIKVISR--DNLLHQQMLQSEIQAMKKLRHKHILALY 68 Query: 88 NAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDR----MSYLL---YQMLCGIKHL 140 + VY++ ELM ++++ D D +S LL +Q+ G+ +L Sbjct: 69 AVVSVG------DPVYIITELMAKG--SLLELLRDSDEKVLPVSELLDIAWQVAEGMCYL 120 Query: 141 HSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGT-TFMMTPYVVTRYYRAPEVILGMG 199 S IHRDL NI+V + K+ DFGLAR ++ + + + APE + Sbjct: 121 ESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEALSRGH 180 Query: 200 YTENVDIWSVGCIMGEMI-RGGVLFPGTDHIDQWNKIIEQLGTPSP 244 Y+ D+WS G ++ EM RG V +PG + + + ++ P P Sbjct: 181 YSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCP 226 >5UIU-A nrPDB Length = 323 Score = 77.4 bits (189), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 80/254 (31%), Positives = 114/254 (44%), Gaps = 48/254 (18%) Query: 5 QHQHYTVEVGDTNFTIHSRY--------INLRPI-------GSGAQGIVCAAYDTITQQN 49 Q ++ ++EV DT F S Y + RPI G G G+V Y + Sbjct: 15 QGENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGY--VNNTT 72 Query: 50 VAIKKLSRPFQNVTHA-KRAY-REFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVM- 106 VA+KKL+ T K+ + +E K+M H+N++ LL F+ + ++ VY+ M Sbjct: 73 VAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELL-GFSS--DGDDLCLVYVYMP 129 Query: 107 --ELMDANLCQVIQMDLDHDRMSYLLYQMLC--------GIKHLHSAGIIHRDLKPSNIV 156 L+D C D L + M C GI LH IHRD+K +NI+ Sbjct: 130 NGSLLDRLSCL--------DGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANIL 181 Query: 157 VKADCTLKILDFGLARTA---GTTFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIM 213 + T KI DFGLAR + T M + V T Y APE + G T DI+S G ++ Sbjct: 182 LDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGE-ITPKSDIYSFGVVL 240 Query: 214 GEMIRGGVLFPGTD 227 E+I G P D Sbjct: 241 LEIITG---LPAVD 251 >3ORP-A nrPDB Length = 311 Score = 77.4 bits (189), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 66/236 (27%), Positives = 108/236 (45%), Gaps = 29/236 (12%) Query: 1 MTTAQHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPF- 59 MTT H E+G+ +G G V A D ++VA+K L Sbjct: 4 MTTPSHLSDRYELGEI-------------LGFGGMSEVHLARDLRDHRDVAVKVLRADLA 50 Query: 60 QNVTHAKRAYREFKLMKLVNHKNIIGLLN---AFTPQRNLEEFQDVYLVMELMDA-NLCQ 115 ++ + R RE + +NH I+ + + A TP L Y+VME +D L Sbjct: 51 RDPSFYLRFRREAQNAAALNHPAIVAVYDTGEAETPAGPLP-----YIVMEYVDGVTLRD 105 Query: 116 VIQMD--LDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLART 173 ++ + + R ++ + H GIIHRD+KP+NI++ A +K++DFG+AR Sbjct: 106 IVHTEGPMTPKRAIEVIADACQALNFSHQNGIIHRDVKPANIMISATNAVKVMDFGIARA 165 Query: 174 ---AGTTFMMTPYVV-TRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPG 225 +G + T V+ T Y +PE G D++S+GC++ E++ G F G Sbjct: 166 IADSGNSVTQTAAVIGTAQYLSPEQARGDSVDARSDVYSLGCVLYEVLTGEPPFTG 221 >2J90-A nrPDB Length = 304 Score = 77.4 bits (189), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 84/314 (26%), Positives = 136/314 (43%), Gaps = 76/314 (24%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIK-----KLSRPFQNVTHAKRAYREFKLMKLVNHKNII 84 +GSG IV T + A K +LS + V+ + RE +++ + H NII Sbjct: 34 LGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSR-EEIEREVNILREIRHPNII 92 Query: 85 GLLNAFTPQRNLEEFQDVYLVMELMDAN-LCQVI--QMDLDHDRMSYLLYQMLCGIKHLH 141 L + F E DV L++EL+ L + + L D + L Q+L G+ +LH Sbjct: 93 TLHDIF------ENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDGVHYLH 146 Query: 142 SAGIIHRDLKPSNIVV----KADCTLKILDFGLART--AGTTF---MMTPYVVTRYYRAP 192 S I H DLKP NI++ + +K++DFG+A AG F TP V AP Sbjct: 147 SKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFV-----AP 201 Query: 193 EVI----LGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQ 248 E++ LG+ D+WS+G I ++ G SP + Sbjct: 202 EIVNYEPLGL----EADMWSIGVITYILLSGA----------------------SPFLGE 235 Query: 249 RLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQR 308 Q T+ N Y FD + F N + A++ + ++LV DP++R Sbjct: 236 TKQETLTNI-----SAVNYDFDEEY----FSNTSEL--------AKDFIRRLLVKDPKRR 278 Query: 309 ISVDEALKHEYINV 322 +++ ++L+H +I Sbjct: 279 MTIAQSLEHSWIKA 292 >3KK8-A nrPDB Length = 284 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 69/294 (23%), Positives = 127/294 (43%), Gaps = 45/294 (15%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNA 89 +G GA +V T A K ++ + ++ RE ++ + + H NI+ L ++ Sbjct: 14 LGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQHPNIVRLHDS 73 Query: 90 FTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRD 149 + D+ EL + + + + D S+ + Q+L I + HS GI+HR+ Sbjct: 74 IQEESFHYLVFDLVTGGELFEDIVAREFYSEAD---ASHCIQQILESIAYCHSNGIVHRN 130 Query: 150 LKPSNIVVKAD---CTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGYTENVDI 206 LKP N+++ + +K+ DFGLA + + T Y +PEV+ Y++ VDI Sbjct: 131 LKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVLKKDPYSKPVDI 190 Query: 207 WSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENRPRYTG 266 W+ G I+ ++ G F D RL ++ + Y Sbjct: 191 WACGVILYILLVGYPPFWDEDQ-------------------HRLYAQIKAGAYD---YPS 228 Query: 267 YSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEYI 320 +D + P +A++L+ ML ++P++RI+ D+ALK +I Sbjct: 229 PEWDTVTP-----------------EAKSLIDSMLTVNPKKRITADQALKVPWI 265 >3UTO-A nrPDB Length = 573 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 72/298 (24%), Positives = 124/298 (41%), Gaps = 55/298 (18%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNA 89 +G+GA G+V + T N A K + P ++ R +E + M ++ H ++ L +A Sbjct: 165 LGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKETVR--KEIQTMSVLRHPTLVNLHDA 222 Query: 90 FTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSY-----LLYQMLCGIKHLHSAG 144 F E+ ++ ++ E M D +H++MS + Q+ G+ H+H Sbjct: 223 F------EDDNEMVMIYEFMSGGELFEKVAD-EHNKMSEDEAVEYMRQVCKGLCHMHENN 275 Query: 145 IIHRDLKPSNIV--VKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGYTE 202 +H DLKP NI+ K LK++DFGL + T + APEV G Sbjct: 276 YVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTTGTAEFAAPEVAEGKPVGY 335 Query: 203 NVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENRP 262 D+WSVG + ++ G F G + + T+RN Sbjct: 336 YTDMWSVGVLSYILLSGLSPFGGENDDE----------------------TLRNV----- 368 Query: 263 RYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEYI 320 S D D F + D ++ + K+L+ DP R+++ +AL+H ++ Sbjct: 369 ----KSCDWNMDDSAFSG--------ISEDGKDFIRKLLLADPNTRMTIHQALEHPWL 414 >3FXW-A nrPDB Length = 336 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 76/304 (25%), Positives = 123/304 (40%), Gaps = 60/304 (19%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKL---SRPFQNVTHAKRAYREFKLMKLVNHKNIIGL 86 +G G G V + T Q A+K L + Q V H +A +I+ + Sbjct: 37 LGLGVNGKVLECFHRRTGQKCALKLLYDSPKARQEVDHHWQA---------SGGPHIVCI 87 Query: 87 LNAFTPQRNLEEFQDVYLV-MELMDAN-LCQVIQMDLDHD----RMSYLLYQMLCGIKHL 140 L+ + N+ + L+ ME M+ L IQ D + ++ + I+ L Sbjct: 88 LDVY---ENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFL 144 Query: 141 HSAGIIHRDLKPSNIVVKA---DCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILG 197 HS I HRD+KP N++ + D LK+ DFG A+ + TP T YY APEV+ Sbjct: 145 HSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNALQTP-CYTPYYVAPEVLGP 203 Query: 198 MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNY 257 Y ++ D+WS+G IM ++ G P F + Sbjct: 204 EKYDKSCDMWSLGVIMYILLCG-----------------------FPPFYSNTGQAISPG 240 Query: 258 VENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKH 317 ++ R R Y F N + DA+ L+ +L DP +R+++ + + H Sbjct: 241 MKRRIRLGQYGFP------------NPEWSEVSEDAKQLIRLLLKTDPTERLTITQFMNH 288 Query: 318 EYIN 321 +IN Sbjct: 289 PWIN 292 >2Y7J-A nrPDB Length = 365 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 73/310 (23%), Positives = 134/310 (43%), Gaps = 67/310 (21%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIK-------KLS-RPFQNVTHAKRAYREFKLMKLV-NH 80 IG G +V T A+K +LS + V A R RE +++ V H Sbjct: 102 IGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATR--RETHILRQVAGH 159 Query: 81 KNIIGLLNAFTPQRNLEEFQDVYLVMELM-DANLCQVI--QMDLDHDRMSYLLYQMLCGI 137 +II L++++ E ++LV +LM L + ++ L ++ +L + Sbjct: 160 PHIITLIDSY------ESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLEAV 213 Query: 138 KHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILG 197 LH+ I+HRDLKP NI++ + +++ DFG + + T Y APE++ Sbjct: 214 SFLHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEPGEKLRELCGTPGYLAPEILKC 273 Query: 198 M------GYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQ 251 GY + VD+W+ G I+ ++ G SP F R Q Sbjct: 274 SMDETHPGYGKEVDLWACGVILFTLLAG-----------------------SPPFWHRRQ 310 Query: 252 -PTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRIS 310 +R +E + +++ +D ++S ++L+S++L +DPE R++ Sbjct: 311 ILMLRMIMEGQYQFSSPEWDD-----------------RSSTVKDLISRLLQVDPEARLT 353 Query: 311 VDEALKHEYI 320 ++AL+H + Sbjct: 354 AEQALQHPFF 363 >6CMJ-A nrPDB Length = 321 Score = 76.6 bits (187), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 56/210 (26%), Positives = 103/210 (49%), Gaps = 21/210 (10%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRP---------FQNVTHAKRAYREFKLMKLVNH 80 IG G+ G+V AY+ A+K LS+ Q ++ Y+E ++K ++H Sbjct: 42 IGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGGCIQPRGPIEQVYQEIAILKKLDH 101 Query: 81 KNIIGLLNAFT-PQRNLEEFQDVYLVMELMDANLCQVIQM--DLDHDRMSYLLYQMLCGI 137 N++ L+ P + +Y+V EL++ + L D+ + ++ GI Sbjct: 102 PNVVKLVEVLDDPNED-----HLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI 156 Query: 138 KHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLART-AGTTFMMTPYVVTRYYRAPEVIL 196 ++LH IIHRD+KPSN++V D +KI DFG++ G+ +++ V T + APE + Sbjct: 157 EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS 216 Query: 197 ---GMGYTENVDIWSVGCIMGEMIRGGVLF 223 + + +D+W++G + + G F Sbjct: 217 ETRKIFSGKALDVWAMGVTLYCFVFGQCPF 246 >4QMW-A nrPDB Length = 310 Score = 76.6 bits (187), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 54/199 (27%), Positives = 94/199 (47%), Gaps = 10/199 (5%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNI 83 + L IG G+ G V D TQ+ VAIK + + + +E ++ + + Sbjct: 31 FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDL-EEAEDEIEDIQQEITVLSQCDSPYV 89 Query: 84 IGLLNAFTPQRNLEEFQDVYLVMELMDAN--LCQVIQMDLDHDRMSYLLYQMLCGIKHLH 141 ++ L +++ME + L + LD +++ +L ++L G+ +LH Sbjct: 90 TKYYGSYLKDTKL------WIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLH 143 Query: 142 SAGIIHRDLKPSNIVVKADCTLKILDFGLA-RTAGTTFMMTPYVVTRYYRAPEVILGMGY 200 S IHRD+K +N+++ +K+ DFG+A + T +V T ++ APEVI Y Sbjct: 144 SEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAY 203 Query: 201 TENVDIWSVGCIMGEMIRG 219 DIWS+G E+ RG Sbjct: 204 DSKADIWSLGITAIELARG 222 >4KIK-B nrPDB Length = 677 Score = 76.6 bits (187), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 62/223 (27%), Positives = 97/223 (43%), Gaps = 20/223 (8%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNA 89 +G+G G V ++ T + +AIK+ + + + +R E ++M+ + H N++ + Sbjct: 27 LGTGGFGNVIRWHNQETGEQIAIKQCRQEL-SPRNRERWCLEIQIMRRLTHPNVVAARDV 85 Query: 90 FTPQRNLEEFQDVYLVMELMDA-----------NLCQVIQMDLDHDRMSYLLYQMLCGIK 138 +NL L ME N C L + LL + ++ Sbjct: 86 PEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCC-----GLREGAILTLLSDIASALR 140 Query: 139 HLHSAGIIHRDLKPSNIVVKAD---CTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVI 195 +LH IIHRDLKP NIV++ KI+D G A+ + T +V T Y APE++ Sbjct: 141 YLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELL 200 Query: 196 LGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQ 238 YT VD WS G + E I G F QW+ + Q Sbjct: 201 EQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQ 243 >2BDW-A nrPDB Length = 362 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 69/294 (23%), Positives = 127/294 (43%), Gaps = 45/294 (15%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNA 89 +G GA +V T A K ++ + ++ RE ++ + + H NI+ L ++ Sbjct: 37 LGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQHPNIVRLHDS 96 Query: 90 FTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRD 149 + D+ EL + + + + D S+ + Q+L I + HS GI+HR+ Sbjct: 97 IQEESFHYLVFDLVTGGELFEDIVAREFYSEAD---ASHCIQQILESIAYCHSNGIVHRN 153 Query: 150 LKPSNIVVKAD---CTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGYTENVDI 206 LKP N+++ + +K+ DFGLA + + T Y +PEV+ Y++ VDI Sbjct: 154 LKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVLKKDPYSKPVDI 213 Query: 207 WSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENRPRYTG 266 W+ G I+ ++ G F D RL ++ + Y Sbjct: 214 WACGVILYILLVGYPPFWDEDQ-------------------HRLYAQIKAGAYD---YPS 251 Query: 267 YSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEYI 320 +D + P +A++L+ ML ++P++RI+ D+ALK +I Sbjct: 252 PEWDTVTP-----------------EAKSLIDSMLTVNPKKRITADQALKVPWI 288 >4UY9-A nrPDB Length = 323 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 77/257 (29%), Positives = 116/257 (45%), Gaps = 30/257 (11%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSR-PFQNVTHAKRAYR-EFKLMKLVNHKNIIGLL 87 IG G G V A+ VA+K P ++++ R E KL ++ H NII L Sbjct: 17 IGIGGFGKVYRAF--WIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALR 74 Query: 88 NAFTPQRNLEEFQDVYLVMELMDAN-LCQVIQMD-LDHDRMSYLLYQMLCGIKHLHSAGI 145 + NL LVME L +V+ + D + Q+ G+ +LH I Sbjct: 75 GVCLKEPNL------CLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAI 128 Query: 146 ---IHRDLKPSNIVVK--------ADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEV 194 IHRDLK SNI++ ++ LKI DFGLAR T M+ T + APEV Sbjct: 129 VPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSA-AGTYAWMAPEV 187 Query: 195 ILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHID-QWNKIIEQLGTPSPS-----FMQ 248 I +++ D+WS G ++ E++ G V F G D + + + +L P PS F + Sbjct: 188 IRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAK 247 Query: 249 RLQPTVRNYVENRPRYT 265 ++ +RP +T Sbjct: 248 LMEDCWNPDPHSRPSFT 264 >2XNP-A nrPDB Length = 279 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 63/209 (30%), Positives = 104/209 (49%), Gaps = 23/209 (11%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAY--REFKLMKLVNHK 81 Y L IG+G+ G C + + + K + ++T A++ E L++ + H Sbjct: 8 YEVLYTIGTGSYG-RCQKIRRKSDGKILVWK-ELDYGSMTEAEKQMLVSEVNLLRELKHP 65 Query: 82 NIIGLLNAFTPQRNLEEFQDVYLVMELMDA-NLCQVIQMD------LDHDRMSYLLYQML 134 NI+ + + N +Y+VME + +L VI LD + + ++ Q+ Sbjct: 66 NIVRYYDRIIDRTN----TTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLT 121 Query: 135 CGIKHLH--SAG---IIHRDLKPSNIVVKADCTLKILDFGLARTAG--TTFMMTPYVVTR 187 +K H S G ++HRDLKP+N+ + +K+ DFGLAR T+F T +V T Sbjct: 122 LALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKT-FVGTP 180 Query: 188 YYRAPEVILGMGYTENVDIWSVGCIMGEM 216 YY +PE + M Y E DIWS+GC++ E+ Sbjct: 181 YYMSPEQMNRMSYNEKSDIWSLGCLLYEL 209 >3PPZ-A nrPDB Length = 309 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 63/199 (31%), Positives = 98/199 (49%), Gaps = 23/199 (11%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRA---YREFKLMKLVNHKNIIGL 86 IG+G+ G V A +VA+K L + HA+R RE +MK + H NI+ Sbjct: 45 IGAGSFGTVHRA--EWHGSDVAVKIL---MEQDFHAERVNEFLREVAIMKRLRHPNIVLF 99 Query: 87 LNAFTPQRNLEEFQDVYLVME-LMDANLCQVIQMD-----LDHDRMSYLLYQMLCGIKHL 140 + A T NL +V E L +L +++ LD R + Y + G+ +L Sbjct: 100 MGAVTQPPNLS------IVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAKGMNYL 153 Query: 141 HSAG--IIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVV-TRYYRAPEVILG 197 H+ I+HRDLK N++V T+K+ DFGL+R +TF+ + T + APEV+ Sbjct: 154 HNRNPPIVHRDLKSPNLLVDKKYTVKVCDFGLSRLKASTFLSSKSAAGTPEWMAPEVLRD 213 Query: 198 MGYTENVDIWSVGCIMGEM 216 E D++S G I+ E+ Sbjct: 214 EPSNEKSDVYSFGVILWEL 232 >5EG3-A nrPDB Length = 334 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 69/230 (30%), Positives = 102/230 (44%), Gaps = 40/230 (17%) Query: 28 RPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYR-------------EFKL 74 +P+G GA G V A + V I K +P + VT A + + E ++ Sbjct: 41 KPLGEGAFGQVVMA------EAVGIDK-DKPKEAVTVAVKMLKDDATEKDLSDLVSEMEM 93 Query: 75 MKLVN-HKNIIGLLNAFT------------PQRNLEEFQDVYLV--MELMDANLCQVIQM 119 MK++ HKNII LL A T + NL E+ MEL ++ +V + Sbjct: 94 MKMIGKHKNIINLLGACTQDGPLYVIVAYASKGNLREYLRARRPPGMEL-SPDINRVPEE 152 Query: 120 DLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFM 179 + + YQ+ G+++L S IHRDL N++V + +KI DFGLAR Sbjct: 153 QMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDF 212 Query: 180 MTPYVVTRY---YRAPEVILGMGYTENVDIWSVGCIMGEMIR-GGVLFPG 225 R + APE + YT D+WS G +M E+ GG +PG Sbjct: 213 FKETTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPG 262 >4YHJ-A nrPDB Length = 584 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 58/235 (24%), Positives = 106/235 (45%), Gaps = 12/235 (5%) Query: 28 RPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKR-AYREFKLMKLVNHKNIIGL 86 R +G G G VCA T + A KKL + + A E ++++ V + ++ L Sbjct: 191 RVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQSRFVVSL 250 Query: 87 LNAFTPQRNLEEFQDVYLVMELMDAN-----LCQVIQMDLDHDRMSYLLYQMLCGIKHLH 141 A+ + L LV+ +M+ + + D R + ++ CG++ L Sbjct: 251 AYAYETKDAL------CLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQ 304 Query: 142 SAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGYT 201 I++RDLKP NI++ ++I D GLA + V T Y APEV+ YT Sbjct: 305 RERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNNEKYT 364 Query: 202 ENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRN 256 + D W +GC++ EMI+G F +W ++ +++ + + ++ ++ Sbjct: 365 FSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKS 419 >1KOB-A nrPDB Length = 387 Score = 75.9 bits (185), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 66/305 (21%), Positives = 132/305 (43%), Gaps = 45/305 (14%) Query: 19 TIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLV 78 +++ Y L +GSGA G+V + T + K ++ P+ + + E +M + Sbjct: 48 SVYDYYDILEELGSGAFGVVHRCVEKATGRVFVAKFINTPYPLDKYTVK--NEISIMNQL 105 Query: 79 NHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGIK 138 +H +I L +AF + + + EL D + +M + + ++Y+ Q G+K Sbjct: 106 HHPKLINLHDAFEDKYEMVLILEFLSGGELFDRIAAEDYKMS-EAEVINYMR-QACEGLK 163 Query: 139 HLHSAGIIHRDLKPSNIV--VKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVIL 196 H+H I+H D+KP NI+ K ++KI+DFGLA ++ T + APE++ Sbjct: 164 HMHEHSIVHLDIKPENIMCETKKASSVKIIDFGLATKLNPDEIVKVTTATAEFAAPEIVD 223 Query: 197 GMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRN 256 D+W++G + ++ G F G D ++ T++N Sbjct: 224 REPVGFYTDMWAIGVLGYVLLSGLSPFAGEDDLE----------------------TLQN 261 Query: 257 YVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALK 316 + +F + P +A++ + +L +P +R++V +AL+ Sbjct: 262 VKRCDWEFDEDAFSSVSP-----------------EAKDFIKNLLQKEPRKRLTVHDALE 304 Query: 317 HEYIN 321 H ++ Sbjct: 305 HPWLK 309 >3C51-A nrPDB Length = 543 Score = 75.9 bits (185), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 67/246 (27%), Positives = 118/246 (47%), Gaps = 17/246 (6%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHA-KRAYREFKLMKLVNHKN 82 +++ R +G G G V A T + A KKL++ + A E K++ V+ + Sbjct: 187 FLDFRVLGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILAKVHSRF 246 Query: 83 IIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHD-------RMSYLLYQMLC 135 I+ L AF E D+ LVM +M+ + ++D D R + Q++ Sbjct: 247 IVSLAYAF------ETKTDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQIVS 300 Query: 136 GIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLA--RTAGTTFMMTPYVVTRYYRAPE 193 G++HLH II+RDLKP N+++ D ++I D GLA AG T Y T + APE Sbjct: 301 GLEHLHQRNIIYRDLKPENVLLDDDGNVRISDLGLAVELKAGQT-KTKGYAGTPGFMAPE 359 Query: 194 VILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPT 253 ++LG Y +VD +++G + EMI F + ++ +++ + ++ + P Sbjct: 360 LLLGEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKQRVLEQAVTYPDKFSPA 419 Query: 254 VRNYVE 259 +++ E Sbjct: 420 SKDFCE 425 >2UV2-A nrPDB Length = 325 Score = 75.5 bits (184), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 58/222 (26%), Positives = 103/222 (46%), Gaps = 23/222 (10%) Query: 5 QHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTH 64 Q++H T ++ +F + + +G GA G V A + T A K + ++ Sbjct: 25 QYEHVTRDLNPEDF-----WEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDT--KSEEE 77 Query: 65 AKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLD-- 122 + E ++ +H NI+ LL+AF + NL ++++E + ++L+ Sbjct: 78 LEDYMVEIDILASCDHPNIVKLLDAFYYENNL------WILIEFCAGGAVDAVMLELERP 131 Query: 123 --HDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGL-ARTAGTTFM 179 ++ + Q L + +LH IIHRDLK NI+ D +K+ DFG+ A+ T Sbjct: 132 LTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQR 191 Query: 180 MTPYVVTRYYRAPEVIL-----GMGYTENVDIWSVGCIMGEM 216 ++ T Y+ APEV++ Y D+WS+G + EM Sbjct: 192 RDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEM 233 >4CQG-A nrPDB Length = 331 Score = 75.5 bits (184), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 74/299 (24%), Positives = 129/299 (43%), Gaps = 60/299 (20%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNA 89 IG+G V A +T + VAIK + + + R E +K + H++I L + Sbjct: 17 IGTGGFAKVKLACHVLTGEMVAIKIMDKNALG-SDLPRVKTEIDALKSLRHQHICQLYHV 75 Query: 90 FTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMS-----YLLYQMLCGIKHLHSAG 144 LE +++V+E ++ + DR+S + Q+L + ++HS G Sbjct: 76 ------LETKNKIFMVLEYCPGG--ELFDYIISQDRLSEEETRVVFRQILSAVAYVHSQG 127 Query: 145 IIHRDLKPSNIVVKADCTLKILDFGL-ARTAGTT-FMMTPYVVTRYYRAPEVILGMGYT- 201 HRDLKP N++ + LK++DFGL A+ G + + + Y APE+I G Y Sbjct: 128 YAHRDLKPENLLFDENHKLKLIDFGLCAKPKGNKDYHLQECCGSLAYAAPELIQGKSYLG 187 Query: 202 ENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENR 261 D+WS+G ++ ++ G + F + + + KI+ R Sbjct: 188 SEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIM------------------------R 223 Query: 262 PRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEYI 320 +Y P L P+ + LL +ML +DP++RIS+ L H ++ Sbjct: 224 GKYE-------VPKWLSPS------------SILLLQQMLQVDPKKRISMRNLLNHPWV 263 >3UDB-A nrPDB Length = 317 Score = 75.5 bits (184), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 73/300 (24%), Positives = 121/300 (40%), Gaps = 46/300 (15%) Query: 23 RYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKN 82 RY ++ IG+G G+ D + VA+K + R + + KR E + + H N Sbjct: 20 RYELVKDIGAGNFGVARLMRDKQANELVAVKYIERGEKIDENVKR---EIINHRSLRHPN 76 Query: 83 IIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGIKHLHS 142 I+ +L + EL + +C + D R + Q++ G+ + H+ Sbjct: 77 IVRFKEVILTPTHLAIVMEYASGGELFE-RICNAGRFSEDEAR--FFFQQLISGVSYAHA 133 Query: 143 AGIIHRDLKPSNIVVKADCT--LKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGY 200 + HRDLK N ++ LKI DFG ++ + V T Y APEV+L Y Sbjct: 134 MQVAHRDLKLENTLLDGSPAPRLKIADFGYSKASVLHSQPKSAVGTPAYIAPEVLLKKEY 193 Query: 201 TENV-DIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVE 259 V D+WS G + M+ G F + + K I ++ +Q + +YV Sbjct: 194 DGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRI--------LNVQYAIPDYVH 245 Query: 260 NRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEY 319 P + R+L+S++ V DP +RIS+ E HE+ Sbjct: 246 ISP-----------------------------ECRHLISRIFVADPAKRISIPEIRNHEW 276 >6AO5-A nrPDB Length = 362 Score = 75.1 bits (183), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 76/300 (25%), Positives = 128/300 (42%), Gaps = 55/300 (18%) Query: 27 LRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGL 86 L +G G+ G V A + Q VAIK++ P + + + +E +M+ + ++ Sbjct: 15 LEKLGEGSYGSVFKAIHKESGQVVAIKQV--PVE--SDLQEIIKEISIMQQCDSPYVVKY 70 Query: 87 LNAFTPQRNLEEFQDVYLVMELMDA-NLCQVIQM---DLDHDRMSYLLYQMLCGIKHLHS 142 ++ D+++VME A ++ +I++ L D ++ +L L G+++LH Sbjct: 71 YGSYFKN------TDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHF 124 Query: 143 AGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVV-TRYYRAPEVILGMGYT 201 IHR++K NI++ + K+ DFG+A T V+ T ++ APEVI +GY Sbjct: 125 MRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYN 184 Query: 202 ENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENR 261 DIWS+G EM G P I I P P+F + Sbjct: 185 CVADIWSLGITSIEMAEGK---PPYADIHPMRAIFMIPTNPPPTF-------------RK 228 Query: 262 PRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEYIN 321 P L+ D D + + K LV +PEQR + + L+H +I Sbjct: 229 P--------ELWSD----------------DFTDFVKKCLVKNPEQRATATQLLQHPFIK 264 >3ZUT-A nrPDB Length = 362 Score = 75.1 bits (183), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 73/300 (24%), Positives = 122/300 (40%), Gaps = 46/300 (15%) Query: 23 RYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKN 82 RY ++ IGSG G+ D + + VA+K + R + + KR E + + H N Sbjct: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKR---EIINHRSLRHPN 76 Query: 83 IIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGIKHLHS 142 I+ +L + EL + +C + D R + Q++ G+ + H+ Sbjct: 77 IVRFKEVILTPTHLAIVMEYASGGELFE-RICNAGRFSEDEAR--FFFQQLISGVSYCHA 133 Query: 143 AGIIHRDLKPSNIVVKADCT--LKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGY 200 + HRDLK N ++ LKI FG ++++ V T Y APEV+L Y Sbjct: 134 MQVCHRDLKLENTLLDGSPAPRLKICAFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEY 193 Query: 201 TENV-DIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVE 259 V D+WS G + M+ G F + + K I ++ +Q + +YV Sbjct: 194 DGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRI--------LNVQYAIPDYVH 245 Query: 260 NRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEY 319 P + R+L+S++ V DP +RIS+ E HE+ Sbjct: 246 ISP-----------------------------ECRHLISRIFVADPAKRISIPEIRNHEW 276 >2A1A-B nrPDB Length = 284 Score = 75.1 bits (183), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 66/218 (30%), Positives = 103/218 (47%), Gaps = 23/218 (10%) Query: 15 DTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKL 74 D F + + I L IGSG G V A I + IK++ + N ++A RE K Sbjct: 6 DKRFGMDFKEIEL--IGSGGFGQVFKAKHRIDGKTYVIKRV--KYNN----EKAEREVKA 57 Query: 75 MKLVNHKNII---GLLNAF-----TPQRNLEEFQD--VYLVMELMD-ANLCQVIQM---- 119 + ++H NI+ G + F T +N + +++ ME D L Q I+ Sbjct: 58 LAKLDHVNIVHYNGCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGE 117 Query: 120 DLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFM 179 LD L Q+ G+ ++HS +I+RDLKPSNI + +KI DFGL + Sbjct: 118 KLDKVLALELFEQITKGVDYIHSKKLINRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGK 177 Query: 180 MTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMI 217 T T Y +PE I Y + VD++++G I+ E++ Sbjct: 178 RTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELL 215 >4LG4-A nrPDB Length = 299 Score = 74.7 bits (182), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 76/300 (25%), Positives = 128/300 (42%), Gaps = 55/300 (18%) Query: 27 LRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGL 86 L +G G+ G V A + Q VAIK++ P + + + +E +M+ + ++ Sbjct: 16 LEKLGEGSYGSVFKAIHKESGQVVAIKQV--PVE--SDLQEIIKEISIMQQCDSPYVVKY 71 Query: 87 LNAFTPQRNLEEFQDVYLVMELMDA-NLCQVIQM---DLDHDRMSYLLYQMLCGIKHLHS 142 ++ D+++VME A ++ +I++ L D ++ +L L G+++LH Sbjct: 72 YGSYFKN------TDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHF 125 Query: 143 AGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVV-TRYYRAPEVILGMGYT 201 IHR++K NI++ + K+ DFG+A T V+ T ++ APEVI +GY Sbjct: 126 MRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYN 185 Query: 202 ENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENR 261 DIWS+G EM G P I I P P+F + Sbjct: 186 CVADIWSLGITSIEMAEGK---PPYADIHPMRAIFMIPTNPPPTF-------------RK 229 Query: 262 PRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEYIN 321 P L+ D D + + K LV +PEQR + + L+H +I Sbjct: 230 P--------ELWSD----------------DFTDFVKKCLVKNPEQRATATQLLQHPFIK 265 >3QA8-A nrPDB Length = 676 Score = 74.7 bits (182), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 60/204 (29%), Positives = 89/204 (43%), Gaps = 20/204 (9%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNA 89 +G+G G V T + VAIK+ + + + +R E ++MK +NH N++ Sbjct: 22 LGTGGFGYVLRWIHQDTGEQVAIKQCRQEL-SPKNRERWCLEIQIMKKLNHPNVVSAREV 80 Query: 90 FTPQRNLEEFQDVYLVMELMDA-----------NLCQVIQMDLDHDRMSYLLYQMLCGIK 138 + L L ME + N C L + LL + ++ Sbjct: 81 PDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCC-----GLKEGPIRTLLSDISSALR 135 Query: 139 HLHSAGIIHRDLKPSNIVVKAD---CTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVI 195 +LH IIHRDLKP NIV++ KI+D G A+ + T +V T Y APE++ Sbjct: 136 YLHENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQGELCTEFVGTLQYLAPELL 195 Query: 196 LGMGYTENVDIWSVGCIMGEMIRG 219 YT VD WS G + E I G Sbjct: 196 EQKKYTVTVDYWSFGTLAFECITG 219 >4GS6-A nrPDB Length = 315 Score = 74.3 bits (181), Expect = 9e-14, Method: Compositional matrix adjust. Identities = 66/199 (33%), Positives = 95/199 (47%), Gaps = 28/199 (14%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNA 89 +G GA G+VC A ++VAIK++ ++ + K E + + VNH NI+ L A Sbjct: 17 VGRGAFGVVCKA--KWRAKDVAIKQI----ESESERKAFIVELRQLSRVNHPNIVKLYGA 70 Query: 90 FTPQRNLEEFQDVYLVMELMDANL-------CQVIQMDLDHDRMSYLLYQMLCGIKHLHS 142 V LVME + + + MS+ L Q G+ +LHS Sbjct: 71 C--------LNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCL-QCSQGVAYLHS 121 Query: 143 ---AGIIHRDLKPSNIVVKADCT-LKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGM 198 +IHRDLKP N+++ A T LKI DFG A T MT + + APEV G Sbjct: 122 MQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTH--MTNNKGSAAWMAPEVFEGS 179 Query: 199 GYTENVDIWSVGCIMGEMI 217 Y+E D++S G I+ E+I Sbjct: 180 NYSEKCDVFSWGIILWEVI 198 >5D7A-A nrPDB Length = 308 Score = 73.9 bits (180), Expect = 9e-14, Method: Compositional matrix adjust. Identities = 62/207 (29%), Positives = 95/207 (45%), Gaps = 23/207 (11%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNA 89 +G+G G V T Q AIK + K+ K K +H+NI A Sbjct: 25 VGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLK--KYSHHRNIATYYGA 82 Query: 90 FTPQRNLEEFQDVYLVMELMDA-NLCQVIQMD----LDHDRMSYLLYQMLCGIKHLHSAG 144 F + ++LVME A ++ +I+ L + ++Y+ ++L G+ HLH Sbjct: 83 FIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHK 142 Query: 145 IIHRDLKPSNIVVKADCTLKILDFG----LARTAG--TTFMMTPYVVTRYYRAPEVIL-- 196 +IHRD+K N+++ + +K++DFG L RT G TF+ TP Y+ APEVI Sbjct: 143 VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTP-----YWMAPEVIACD 197 Query: 197 ---GMGYTENVDIWSVGCIMGEMIRGG 220 Y D+WS+G EM G Sbjct: 198 ENPDATYDFKSDLWSLGITAIEMAEGA 224 >4U41-A nrPDB Length = 332 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 62/207 (29%), Positives = 90/207 (43%), Gaps = 23/207 (11%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNA 89 +G+G G V T Q AIK + K K K +H+NI A Sbjct: 32 VGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLK--KYSHHRNIATYYGA 89 Query: 90 FTPQRNLEEFQDVYLVMELMDANLCQVIQMD-----LDHDRMSYLLYQMLCGIKHLHSAG 144 F + ++LVME A + + L D ++Y+ ++L G+ HLH Sbjct: 90 FIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAHLHIHH 149 Query: 145 IIHRDLKPSNIVVKADCTLKILDFG----LARTAG--TTFMMTPYVVTRYYRAPEVIL-- 196 +IHRD+K N+++ + +K++DFG L RT G TF+ TP Y+ APEVI Sbjct: 150 VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTP-----YWMAPEVIACD 204 Query: 197 ---GMGYTENVDIWSVGCIMGEMIRGG 220 Y D+WS G EM G Sbjct: 205 ENPDATYDYRSDLWSCGITAIEMAEGA 231 >2PSQ-A nrPDB Length = 370 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 68/229 (29%), Positives = 102/229 (44%), Gaps = 38/229 (16%) Query: 28 RPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYR-------------EFKL 74 +P+G G G V A + V I K +P + VT A + + E ++ Sbjct: 87 KPLGEGCFGQVVMA------EAVGIDK-DKPKEAVTVAVKMLKDDATEKDLSDLVSEMEM 139 Query: 75 MKLVN-HKNIIGLLNAFT---PQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDR----- 125 MK++ HKNII LL A T P + E+ + E + A ++ D +R Sbjct: 140 MKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQ 199 Query: 126 MSY-----LLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMM 180 M++ YQ+ G+++L S IHRDL N++V + +KI DFGLAR Sbjct: 200 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY 259 Query: 181 TPYVVTRY---YRAPEVILGMGYTENVDIWSVGCIMGEMIR-GGVLFPG 225 R + APE + YT D+WS G +M E+ GG +PG Sbjct: 260 KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPG 308 >2HW6-A nrPDB Length = 307 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 82/314 (26%), Positives = 139/314 (44%), Gaps = 56/314 (17%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAK-RAYREFK-LMKLVNHKNIIGLL 87 +G GA V A + A+K + + H++ R +RE + L + +KNI+ L+ Sbjct: 21 LGEGAYAKVQGAVSLQNGKEYAVKIIEK---QAGHSRSRVFREVETLYQCQGNKNILELI 77 Query: 88 NAFTPQRNLEEFQDVYLVME-LMDANLCQVIQMD--LDHDRMSYLLYQMLCGIKHLHSAG 144 F E+ YLV E L ++ IQ + S ++ + + LH+ G Sbjct: 78 EFF------EDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKG 131 Query: 145 IIHRDLKPSNIVVKAD---CTLKILDF----GLARTAGTTFMMTPYVVT----RYYRAPE 193 I HRDLKP NI+ ++ +KI DF G+ T + TP + T Y APE Sbjct: 132 IAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPE 191 Query: 194 VI-----LGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHID-QWNKIIEQLGTPSPSFM 247 V+ Y + D+WS+G ++ M+ G F G D W++ G Sbjct: 192 VVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDR-----GEVCRVCQ 246 Query: 248 QRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQ 307 +L +++ +Y FPD ++ +S+A++L+SK+LV D +Q Sbjct: 247 NKLFESIQE-----GKYE-------FPD--------KDWAHISSEAKDLISKLLVRDAKQ 286 Query: 308 RISVDEALKHEYIN 321 R+S + L+H ++ Sbjct: 287 RLSAAQVLQHPWVQ 300 >1FOT-A nrPDB Length = 318 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 54/215 (25%), Positives = 105/215 (48%), Gaps = 14/215 (6%) Query: 27 LRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQ-NVTHAKRAYREFKLMKLVNHKNIIG 85 LR +G+G+ G V + A+K L + + + E ++ +V H II Sbjct: 11 LRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTHPFIIR 70 Query: 86 LLNAFTPQRNLEEFQDVYLVMELMDAN-LCQVIQMD--LDHDRMSYLLYQMLCGIKHLHS 142 + F ++ Q ++++M+ ++ L +++ + + ++ +++LHS Sbjct: 71 MWGTF------QDAQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYLHS 124 Query: 143 AGIIHRDLKPSNIVVKADCTLKILDFGLAR-TAGTTFMMTPYVVTRYYRAPEVILGMGYT 201 II+RDLKP NI++ + +KI DFG A+ T+ + T Y APEV+ Y Sbjct: 125 KDIIYRDLKPENILLDKNGHIKITDFGFAKYVPDVTYTLCG---TPDYIAPEVVSTKPYN 181 Query: 202 ENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKII 236 +++D WS G ++ EM+ G F ++ + + KI+ Sbjct: 182 KSIDWWSFGILIYEMLAGYTPFYDSNTMKTYEKIL 216 >5WAX-A nrPDB Length = 310 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 75/301 (24%), Positives = 121/301 (40%), Gaps = 48/301 (15%) Query: 23 RYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKN 82 RY +R IGSG G+ + Q VA+K + R + RE + + H N Sbjct: 12 RYELVRDIGSGNFGVARLMRNRADGQLVAVKYIER---GEKIDENVQREIINHRSLRHPN 68 Query: 83 IIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGIKHLHS 142 II +L + EL + +C + D R + Q++ G+ + HS Sbjct: 69 IIRFKEVILTPTHLAIVMEYASGGELFE-RICNAGRFSEDEAR--FFFQQLISGVSYCHS 125 Query: 143 AGIIHRDLKPSNIVVKADCT--LKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGY 200 + HRDLK N ++ LKI DFG ++++ V T Y APEV+L Y Sbjct: 126 MQVCHRDLKLENTLLDGSTAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEY 185 Query: 201 TENV-DIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQ-LGTPSPSFMQRLQPTVRNYV 258 V D+WS G + M+ G F D + K I++ LG +Q ++ +YV Sbjct: 186 DGKVADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRILG---------VQYSIPDYV 236 Query: 259 ENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHE 318 P + ++L+S++ V +P RI++ E H Sbjct: 237 HISP-----------------------------ECQDLISRIFVANPATRITIPEIRNHP 267 Query: 319 Y 319 + Sbjct: 268 W 268 >2YAB-A nrPDB Length = 361 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 78/309 (25%), Positives = 127/309 (41%), Gaps = 68/309 (22%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIK----KLSRPFQNVTHAKRAYREFKLMKLVNHKNIIG 85 +GSG IV + T A K + SR + + RE +++ V H NII Sbjct: 20 LGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIEREVSILRQVLHPNIIT 79 Query: 86 LLNAFTPQRNLEEFQDVYLVMELMDAN-----LCQVIQMDLDHDRMSYLLYQMLCGIKHL 140 L + + E DV L++EL+ L Q + L + + + Q+L G+ +L Sbjct: 80 LHDVY------ENRTDVVLILELVSGGELFDFLAQ--KESLSEEEATSFIKQILDGVNYL 131 Query: 141 HSAGIIHRDLKPSNIVVKADCT----LKILDFGLARTAGTTFMMTPYVVTRYYRAPEVI- 195 H+ I H DLKP NI++ +K++DFGLA T + APE++ Sbjct: 132 HTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVN 191 Query: 196 ---LGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQP 252 LG+ D+WS+G I ++ G SP Q Sbjct: 192 YEPLGL----EADMWSIGVITYILLSGA----------------------SPFLGDTKQE 225 Query: 253 TVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVD 312 T+ N T S+D F + F + A++ + K+LV + +R+++ Sbjct: 226 TLAN-------ITAVSYD--FDEEFFSQTSEL--------AKDFIRKLLVKETRKRLTIQ 268 Query: 313 EALKHEYIN 321 EAL+H +I Sbjct: 269 EALRHPWIT 277 >3DTC-A nrPDB Length = 271 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 76/257 (29%), Positives = 115/257 (44%), Gaps = 30/257 (11%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSR-PFQNVTHAKRAYR-EFKLMKLVNHKNIIGLL 87 IG G G V A+ VA+K P ++++ R E KL ++ H NII L Sbjct: 15 IGIGGFGKVYRAF--WIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALR 72 Query: 88 NAFTPQRNLEEFQDVYLVMELMDAN-LCQVIQMD-LDHDRMSYLLYQMLCGIKHLHSAGI 145 + NL LVME L +V+ + D + Q+ G+ +LH I Sbjct: 73 GVCLKEPNL------CLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAI 126 Query: 146 ---IHRDLKPSNIVVK--------ADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEV 194 IHRDLK SNI++ ++ LKI DFGLAR T M+ + APEV Sbjct: 127 VPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMS-AAGAYAWMAPEV 185 Query: 195 ILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHID-QWNKIIEQLGTPSPS-----FMQ 248 I +++ D+WS G ++ E++ G V F G D + + + +L P PS F + Sbjct: 186 IRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAK 245 Query: 249 RLQPTVRNYVENRPRYT 265 ++ +RP +T Sbjct: 246 LMEDCWNPDPHSRPSFT 262 >5LOH-A nrPDB Length = 341 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 68/246 (27%), Positives = 117/246 (47%), Gaps = 24/246 (9%) Query: 27 LRPIGSGAQGIVCAAYDTITQQNV-AIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIG 85 ++PI GA G V V +KK +N+TH +A R+ + L I+ Sbjct: 41 VKPISRGAFGKVYLGQKGGKLYAVKVVKKADMINKNMTHQVQAERD--ALALSKSPFIVH 98 Query: 86 LLNAFTPQRNLEEFQDVYLVME-LMDANLCQVIQMD--LDHDRMSYLLYQMLCGIKHLHS 142 L +L+ +VYLVME L+ ++ ++ + D + + ++ + +LH Sbjct: 99 LY------YSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALALDYLHR 152 Query: 143 AGIIHRDLKPSNIVVKADCTLKILDFGLAR-TAGTTFMMTPYVVTRY------YRAPEVI 195 GIIHRDLKP N+++ + +K+ DFGL++ T M + TR Y APE++ Sbjct: 153 HGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILTTRTFCGTPDYLAPELL 212 Query: 196 LGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQ--WNKIIEQLGTPSPSFMQRLQPT 253 LG + VD W++G + E + G + P D Q + I+++ P P ++L Sbjct: 213 LGRAHGPAVDWWALGVCLFEFLTG--IPPFNDETPQQVFQNILKR-DIPWPEGEEKLSDN 269 Query: 254 VRNYVE 259 ++ VE Sbjct: 270 AQSAVE 275 >1ZWS-A nrPDB Length = 288 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 77/309 (24%), Positives = 128/309 (41%), Gaps = 68/309 (22%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIK----KLSRPFQNVTHAKRAYREFKLMKLVNHKNIIG 85 +GSG IV + T A K + SR + + RE +++ V H N+I Sbjct: 20 LGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVLHHNVIT 79 Query: 86 LLNAFTPQRNLEEFQDVYLVMELMDAN-----LCQVIQMDLDHDRMSYLLYQMLCGIKHL 140 L + + E DV L++EL+ L Q + L + + + Q+L G+ +L Sbjct: 80 LHDVY------ENRTDVVLILELVSGGELFDFLAQ--KESLSEEEATSFIKQILDGVNYL 131 Query: 141 HSAGIIHRDLKPSNIVVKADCT----LKILDFGLARTAGTTFMMTPYVVTRYYRAPEVI- 195 H+ I H DLKP NI++ +K++DFGLA T + APE++ Sbjct: 132 HTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVN 191 Query: 196 ---LGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQP 252 LG+ D+WS+G I ++ G SP Q Sbjct: 192 YEPLGL----EADMWSIGVITYILLSGA----------------------SPFLGDTKQE 225 Query: 253 TVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVD 312 T+ N T S+D F + F + + A++ + K+LV + +R+++ Sbjct: 226 TLAN-------ITSVSYD--FDEEFFSHTSEL--------AKDFIRKLLVKETRKRLTIQ 268 Query: 313 EALKHEYIN 321 EAL+H +I Sbjct: 269 EALRHPWIT 277 >2A27-A nrPDB Length = 321 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 77/309 (24%), Positives = 127/309 (41%), Gaps = 68/309 (22%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIK----KLSRPFQNVTHAKRAYREFKLMKLVNHKNIIG 85 +GSG IV + T A K + SR + + RE +++ V H N+I Sbjct: 20 LGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVLHHNVIT 79 Query: 86 LLNAFTPQRNLEEFQDVYLVMELMDAN-----LCQVIQMDLDHDRMSYLLYQMLCGIKHL 140 L + + E DV L++EL+ L Q + L + + + Q+L G+ +L Sbjct: 80 LHDVY------ENRTDVVLILELVSGGELFDFLAQ--KESLSEEEATSFIKQILDGVNYL 131 Query: 141 HSAGIIHRDLKPSNIVVKADCT----LKILDFGLARTAGTTFMMTPYVVTRYYRAPEVI- 195 H+ I H DLKP NI++ +K++DFGLA T + APE++ Sbjct: 132 HTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVN 191 Query: 196 ---LGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQP 252 LG+ D+WS+G I ++ G SP Q Sbjct: 192 YEPLGL----EADMWSIGVITYILLSGA----------------------SPFLGDTKQE 225 Query: 253 TVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVD 312 T+ N T S+D F + F + A++ + K+LV + +R+++ Sbjct: 226 TLAN-------ITAVSYD--FDEEFFSQTSEL--------AKDFIRKLLVKETRKRLTIQ 268 Query: 313 EALKHEYIN 321 EAL+H +I Sbjct: 269 EALRHPWIT 277 >3UIU-A nrPDB Length = 306 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 66/235 (28%), Positives = 107/235 (45%), Gaps = 38/235 (16%) Query: 15 DTNFTIHSRY----INLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYR 70 +T +T+ R+ + IGSG G V A I + I+++ + N ++A R Sbjct: 1 ETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIRRV--KYNN----EKAER 54 Query: 71 EFKLMKLVNHKNII---GLLNAF-----TPQRNLE---------------EFQDVYLVME 107 E K + ++H NI+ G + F T +LE + + +++ ME Sbjct: 55 EVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQME 114 Query: 108 LMD-ANLCQVIQM----DLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCT 162 D L Q I+ LD L Q+ G+ ++HS +IHRDLKPSNI + Sbjct: 115 FCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQ 174 Query: 163 LKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMI 217 +KI DFGL + T T Y +PE I Y + VD++++G I+ E++ Sbjct: 175 VKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELL 229 >5J5T-A nrPDB Length = 370 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 56/195 (28%), Positives = 94/195 (48%), Gaps = 17/195 (8%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLS-RPFQNVTHAKRAYREFKLMKLVNHKNIIGLLN 88 IGSG G V A + T + AIK + P ++ ++ E +MK H NI+ Sbjct: 12 IGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQ---EIIMMKDCKHPNIVAYFG 68 Query: 89 AFTPQRNLEEFQDVYLVMELMDANLCQVI---QMDLDHDRMSYLLYQMLCGIKHLHSAGI 145 ++ + L ++ ME Q I L +++Y+ + L G+ +LHS G Sbjct: 69 SYLRRDKL------WICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSKGK 122 Query: 146 IHRDLKPSNIVVKADCTLKILDFGL-ARTAGTTFMMTPYVVTRYYRAPEVIL---GMGYT 201 +HRD+K +NI++ + +K+ DFG+ A+ T ++ T Y+ APEV GY Sbjct: 123 MHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKAFIGTPYWMAPEVAAVERKGGYN 182 Query: 202 ENVDIWSVGCIMGEM 216 + D+W+VG E+ Sbjct: 183 QLCDLWAVGITAIEL 197 >6FDY-U nrPDB Length = 276 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 77/309 (24%), Positives = 127/309 (41%), Gaps = 72/309 (23%) Query: 30 IGSGAQGIVCAAY-DTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLN 88 +GSG V AY T++ VAIK +++ N + E +++K + H +I+ Sbjct: 19 LGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKGIRHPHIV---- 74 Query: 89 AFTPQRNLEEFQ----DVYLVMEL-MDANLCQVIQMD--LDHDRMSYLLYQMLCGIKHLH 141 L++FQ ++YL+ME +L + I L + Q+ ++ LH Sbjct: 75 ------QLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFLH 128 Query: 142 SAGIIHRDLKPSNIVVKA--DCTLKILDFGLARTAGTTFMMTPYV---VTR---YYRAPE 193 I H DLKP NI++ + LK+ DFG A+ M+P+ V R Y APE Sbjct: 129 ERNISHLDLKPQNILLSSLEKPHLKLADFGFAQH------MSPWDEKHVLRGSPLYMAPE 182 Query: 194 VILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPT 253 ++ Y VD+WS+G I+ E + G F + KI P L+P Sbjct: 183 MVCQRQYDARVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELP-----LRPL 237 Query: 254 VRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDE 313 + + D R+LL ++L DP +RIS + Sbjct: 238 L-----------------------------------SRDCRDLLQRLLERDPSRRISFQD 262 Query: 314 ALKHEYINV 322 H ++++ Sbjct: 263 FFAHPWVDL 271 >6CCF-A nrPDB Length = 290 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 56/225 (24%), Positives = 105/225 (46%), Gaps = 36/225 (16%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSR------------------------PFQNVTHA 65 IG GA G+V AY+ ++ A+K LS+ P + + Sbjct: 13 IGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGGPAKQLLPL 72 Query: 66 KRAYREFKLMKLVNHKNIIGLLNAFT-PQRNLEEFQDVYLVMELMDANLCQVIQMD--LD 122 +R Y+E ++K ++H N++ L+ P + ++YLV +L+ + D Sbjct: 73 ERVYQEIAILKKLDHVNVVKLIEVLDDPAED-----NLYLVFDLLRKGPVMEVPCDKPFS 127 Query: 123 HDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLA-RTAGTTFMMT 181 ++ L ++ G+++LH I+HRD+KPSN+++ D +KI DFG++ + G ++ Sbjct: 128 EEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLS 187 Query: 182 PYVVTRYYRAPEVILGMGYT---ENVDIWSVGCIMGEMIRGGVLF 223 T + APE I G + + +D+W+ G + + G F Sbjct: 188 STAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPF 232 >4K33-A nrPDB Length = 325 Score = 72.0 bits (175), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 67/229 (29%), Positives = 98/229 (42%), Gaps = 38/229 (16%) Query: 28 RPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYR-------------EFKL 74 +P+G GA G V A + + I K R + VT A + + E ++ Sbjct: 42 KPLGEGAFGQVVMA------EAIGIDK-DRAAKPVTVAVKMLKDDATDKDLSDLVSEMEM 94 Query: 75 MKLVN-HKNIIGLLNAFT---PQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDR----- 125 MK++ HKNII LL A T P L E+ + E + A + D + Sbjct: 95 MKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTSKPPEEQ 154 Query: 126 -----MSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMM 180 + YQ+ G+++L S IHRDL N++V D +KI DFGLAR Sbjct: 155 LTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYY 214 Query: 181 TPYVVTRY---YRAPEVILGMGYTENVDIWSVGCIMGEMIR-GGVLFPG 225 R + APE + YT D+WS G ++ E+ GG +PG Sbjct: 215 KETTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPG 263 >3KA0-A nrPDB Length = 320 Score = 72.0 bits (175), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 74/301 (24%), Positives = 125/301 (41%), Gaps = 55/301 (18%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKL-MKLVNHKNIIGLLN 88 +G G G V ++ TQ+ A+K L +A RE +L + +I+ +++ Sbjct: 24 LGLGINGKVLQIFNKRTQEKFALKMLQ-------DCPKARREVELHWRASQCPHIVRIVD 76 Query: 89 AFTPQRNLEEFQDVYL-VMELMDAN-LCQVIQMDLDHD----RMSYLLYQMLCGIKHLHS 142 + NL + L VME +D L IQ D S ++ + I++LHS Sbjct: 77 VY---ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHS 133 Query: 143 AGIIHRDLKPSNIVV---KADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMG 199 I HRD+KP N++ + + LK+ DFG A+ + +T T YY APEV+ Sbjct: 134 INIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTEPCYTPYYVAPEVLGPEK 193 Query: 200 YTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVE 259 Y ++ D+WS+G IM ++ G P F + ++ Sbjct: 194 YDKSCDMWSLGVIMYILLCG-----------------------YPPFYSNHGLAISPGMK 230 Query: 260 NRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEY 319 R R Y F N + + + L+ +L +P QR+++ E + H + Sbjct: 231 TRIRMGQYEFP------------NPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPW 278 Query: 320 I 320 I Sbjct: 279 I 279 >3DB8-A nrPDB Length = 317 Score = 72.0 bits (175), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 60/211 (28%), Positives = 98/211 (46%), Gaps = 21/211 (9%) Query: 23 RYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAK-RAYREFKLMKLVNHK 81 RY+ R +G G D T++ A K + + H K + E + K +++ Sbjct: 43 RYMRGRFLGKGGFAKCYEITDMDTKEVFAGKVVPKSMLLKPHQKEKMSTEIAIHKSLDNP 102 Query: 82 NIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMS--------YLLYQM 133 +++G F E+ VY+V+E+ C+ + H R Y + Q Sbjct: 103 HVVGFHGFF------EDDDFVYVVLEI-----CRRRSLLELHKRRKAVTEPEARYFMRQT 151 Query: 134 LCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLA-RTAGTTFMMTPYVVTRYYRAP 192 + G+++LH+ +IHRDLK N+ + D +KI DFGLA + T Y AP Sbjct: 152 IQGVQYLHNNRVIHRDLKLGNLFLNDDMDVKIGDFGLATKIEFDGERKKDLCGTPNYIAP 211 Query: 193 EVILGMGYTENVDIWSVGCIMGEMIRGGVLF 223 EV+ G++ VDIWS+GCI+ ++ G F Sbjct: 212 EVLCKKGHSFEVDIWSLGCILYTLLVGKPPF 242 >4UYA-A nrPDB Length = 340 Score = 71.6 bits (174), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 75/234 (32%), Positives = 110/234 (47%), Gaps = 29/234 (12%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSR-PFQNVTHAKRAYR-EFKLMKLVNHKNIIGLL 87 IG+G G V A T Q VA+K + P Q+ A + R E +L ++ H NII L Sbjct: 34 IGAGGFGQVYRA--TWQGQEVAVKAARQDPEQDAAAAAESVRREARLFAMLRHPNIIELR 91 Query: 88 NAFTPQRNLEEFQDVYLVMELMDA---NLCQVIQMDLDHDRMSYLLYQMLCGIKHLHSAG 144 Q +L LV+E N + H +++ + Q+ G+ +LH Sbjct: 92 GVCLQQPHL------CLVLEFARGGALNRALAGRRIPPHVLVNWAV-QIARGMLYLHEEA 144 Query: 145 ---IIHRDLKPSNIVVK--------ADCTLKILDFGLARTA-GTTFMMTPYVVTRYYRAP 192 I+HRDLK SNI++ + TLKI DFGLAR TT M T + AP Sbjct: 145 FVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTKMATAGAYA--WMAP 202 Query: 193 EVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHID-QWNKIIEQLGTPSPS 245 EVI +++ DIWS G ++ E++ G V + G D + + + +L P PS Sbjct: 203 EVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLTLPIPS 256 >2OZA-A nrPDB Length = 356 Score = 71.6 bits (174), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 74/301 (24%), Positives = 125/301 (41%), Gaps = 55/301 (18%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKL-MKLVNHKNIIGLLN 88 +G G G V ++ TQ+ A+K L +A RE +L + +I+ +++ Sbjct: 26 LGLGINGKVLQIFNKRTQEKFALKMLQ-------DCPKARREVELHWRASQCPHIVRIVD 78 Query: 89 AFTPQRNLEEFQDVYL-VMELMDAN-LCQVIQMDLDHD----RMSYLLYQMLCGIKHLHS 142 + NL + L VME +D L IQ D S ++ + I++LHS Sbjct: 79 VY---ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHS 135 Query: 143 AGIIHRDLKPSNIVV---KADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMG 199 I HRD+KP N++ + + LK+ DFG A+ + +T T YY APEV+ Sbjct: 136 INIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEK 195 Query: 200 YTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVE 259 Y ++ D+WS+G IM ++ G P F + ++ Sbjct: 196 YDKSCDMWSLGVIMYILLCG-----------------------YPPFYSNHGLAISPGMK 232 Query: 260 NRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEY 319 R R Y F N + + + L+ +L +P QR+++ E + H + Sbjct: 233 TRIRMGQYEFP------------NPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPW 280 Query: 320 I 320 I Sbjct: 281 I 281 >4JXF-A nrPDB Length = 266 Score = 71.2 bits (173), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 60/223 (26%), Positives = 101/223 (45%), Gaps = 32/223 (14%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKL-SRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLN 88 +G G+ V A T VAIK + + +R E K+ + H +I+ L N Sbjct: 15 LGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSILELYN 74 Query: 89 AFTPQRNLEEFQDVYLVMELMDANLCQVIQMD---------LDHDRMSYLLYQMLCGIKH 139 F E+ VYLV+E+ C +M+ + + ++Q++ G+ + Sbjct: 75 YF------EDSNYVYLVLEM-----CHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLY 123 Query: 140 LHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPY------VVTRYYRAPE 193 LHS GI+HRDL SN+++ + +KI DFGLA T + P+ T Y +PE Sbjct: 124 LHSHGILHRDLTLSNLLLTRNMNIKIADFGLA-----TQLKMPHEKHYTLCGTPNYISPE 178 Query: 194 VILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKII 236 + + D+WS+GC+ ++ G F + NK++ Sbjct: 179 IATRSAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVV 221 >1NY3-A nrPDB Length = 400 Score = 71.2 bits (173), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 74/301 (24%), Positives = 125/301 (41%), Gaps = 55/301 (18%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKL-MKLVNHKNIIGLLN 88 +G G G V ++ TQ+ A+K L +A RE +L + +I+ +++ Sbjct: 70 LGLGINGKVLQIFNKRTQEKFALKMLQ-------DCPKARREVELHWRASQCPHIVRIVD 122 Query: 89 AFTPQRNLEEFQDVYL-VMELMDAN-LCQVIQMDLDHD----RMSYLLYQMLCGIKHLHS 142 + NL + L VME +D L IQ D S ++ + I++LHS Sbjct: 123 VY---ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHS 179 Query: 143 AGIIHRDLKPSNIVV---KADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMG 199 I HRD+KP N++ + + LK+ DFG A+ + +T T YY APEV+ Sbjct: 180 INIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEK 239 Query: 200 YTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVE 259 Y ++ D+WS+G IM ++ G P F + ++ Sbjct: 240 YDKSCDMWSLGVIMYILLCG-----------------------YPPFYSNHGLAISPGMK 276 Query: 260 NRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEY 319 R R Y F N + + + L+ +L +P QR+++ E + H + Sbjct: 277 TRIRMGQYEFP------------NPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPW 324 Query: 320 I 320 I Sbjct: 325 I 325 >4FZF-B nrPDB Length = 283 Score = 71.2 bits (173), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 52/199 (26%), Positives = 92/199 (46%), Gaps = 10/199 (5%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNI 83 + L IG G+ G V D TQQ VAIK + + + +E ++ + + Sbjct: 10 FTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLE-EAEDEIEDIQQEITVLSQCDSSYV 68 Query: 84 IGLLNAFTPQRNLEEFQDVYLVMELMDAN--LCQVIQMDLDHDRMSYLLYQMLCGIKHLH 141 ++ L +++ME + L + D +++ +L ++L G+ +LH Sbjct: 69 TKYYGSYLKGSKL------WIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLH 122 Query: 142 SAGIIHRDLKPSNIVVKADCTLKILDFGLA-RTAGTTFMMTPYVVTRYYRAPEVILGMGY 200 S IHRD+K +N+++ +K+ FG+A + T +V T ++ APEVI Y Sbjct: 123 SEKKIHRDIKAANVLLSEQGDVKLAAFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAY 182 Query: 201 TENVDIWSVGCIMGEMIRG 219 DIWS+G E+ +G Sbjct: 183 DSKADIWSLGITAIELAKG 201 >2X7G-A nrPDB Length = 389 Score = 71.2 bits (173), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 96/395 (24%), Positives = 160/395 (40%), Gaps = 107/395 (27%) Query: 8 HYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKR 67 ++ V++GD + RY +R +G G V +D ++ VA+K + + Q+ T + Sbjct: 20 YHPVKIGDL---FNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMK-VVKSAQHYT--ET 73 Query: 68 AYREFKLMKLVNHKNIIGLLNAFTPQRNLE-EFQDVYLVMELMDANLCQVIQMDLDHDRM 126 A E KL+K V + P +++ + D + + + ++C V ++ L H + Sbjct: 74 ALDEIKLLKCVRESD------PSDPNKDMVVQLIDDFKISGMNGIHVCMVFEV-LGHHLL 126 Query: 127 SYLLY----------------QMLCGIKHLHS-AGIIHRDLKPSNIVVKAD--------- 160 +++ Q+L G+ +LHS IIH D+KP NI++ D Sbjct: 127 KWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAA 186 Query: 161 --------------------------------------CTLKILDFGLARTAGTTFMMTP 182 +KI D G A F T Sbjct: 187 EATEWQKAGAPPPSGSAVSTAPAADLLVNPLDPRNADKIRVKIADLGNACWVHKHF--TE 244 Query: 183 YVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLF---PGTDHI---DQWNKII 236 + TR YR+ EV++G GY+ DIWS C+ E+ G LF G D+ D II Sbjct: 245 DIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHII 304 Query: 237 EQLGTP----------SPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNS 286 E LG+ S F R + +R+ + +P FD L +P+++ Sbjct: 305 ELLGSIPRHFALSGKYSREFFNR-RGELRHITKLKPWSL---FDVLVEKYGWPHED---- 356 Query: 287 RRKASDARNLLSKMLVIDPEQRISVDEALKHEYIN 321 A+ + L ML + PE+R S E L+H ++N Sbjct: 357 ---AAQFTDFLIPMLEMVPEKRASAGECLRHPWLN 388 >6CKI-A nrPDB Length = 316 Score = 70.9 bits (172), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 79/313 (25%), Positives = 138/313 (44%), Gaps = 54/313 (17%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLM-KLVNHKNIIGLLN 88 +G GA V + IT Q A+K + + ++ R +RE +++ + H+N++ L+ Sbjct: 21 LGEGAHARVQTCINLITSQEYAVKIIEKQPGHIR--SRVFREVEMLYQCQGHRNVLELIE 78 Query: 89 AFTPQRNLEEFQDVYLVMELMDAN--LCQV-IQMDLDHDRMSYLLYQMLCGIKHLHSAGI 145 F + YLV E M L + + + S ++ + + LH+ GI Sbjct: 79 FFEEEDRF------YLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHNKGI 132 Query: 146 IHRDLKPSNIVVKAD---CTLKILDFGLAR----TAGTTFMMTPYVVT----RYYRAPEV 194 HRDLKP NI+ + +KI DFGL + + TP ++T Y APEV Sbjct: 133 AHRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEV 192 Query: 195 ILGMG-----YTENVDIWSVGCIMGEMIRGGVLFPGTDHID-QWNKIIEQLGTPSPSFMQ 248 + Y + D+WS+G I+ ++ G F G D W++ G P+ Sbjct: 193 VEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDR-----GEACPACQN 247 Query: 249 RLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQR 308 L +++ +Y FPD ++ + A++L+SK+LV D +QR Sbjct: 248 MLFESIQE-----GKYE-------FPD--------KDWAHISCAAKDLISKLLVRDAKQR 287 Query: 309 ISVDEALKHEYIN 321 +S + L+H ++ Sbjct: 288 LSAAQVLQHPWVQ 300 >2WTK-C nrPDB Length = 305 Score = 70.9 bits (172), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 81/350 (23%), Positives = 139/350 (39%), Gaps = 78/350 (22%) Query: 22 SRYINLRPIGSGAQGIVCAAYD--TITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVN 79 +Y+ +G G+ G V D T+ ++ V I K + + +E +L++ + Sbjct: 5 GKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLR 64 Query: 80 HKNIIGLLNAFTPQRNLEEFQDVYLVMEL----MDANLCQVIQMDLDHDRMSYLLYQMLC 135 HKN+I L++ EE Q +Y+VME M L V + + Q++ Sbjct: 65 HKNVIQLVDVLYN----EEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLID 120 Query: 136 GIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVV---------T 186 G+++LHS GI+H+D+KP N+++ TLKI G+A + P+ + Sbjct: 121 GLEYLHSQGIVHKDIKPGNLLLTTGGTLKISALGVAEA------LHPFAADDTCRTSQGS 174 Query: 187 RYYRAPEVILGMGYTEN--VDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSP 244 ++ PE+ G+ VDIWS G + + G F G D K+ E +G S Sbjct: 175 PAFQPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEG----DNIYKLFENIGKGSY 230 Query: 245 SFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVID 304 + P + +LL ML + Sbjct: 231 AIPGDCGPPL---------------------------------------SDLLKGMLEYE 251 Query: 305 PEQRISVDEALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKEL 354 P +R S+ + +H W+ + A AP P S D T ++W+ + Sbjct: 252 PAKRFSIRQIRQHS----WFRKKHPPAEAPVPIPPSPD----TKDRWRSM 293 >5VO2-A nrPDB Length = 300 Score = 70.9 bits (172), Expect = 9e-13, Method: Compositional matrix adjust. Identities = 69/253 (27%), Positives = 110/253 (43%), Gaps = 34/253 (13%) Query: 25 INLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNII 84 ++L+ +GSGAQG V + VA+KK+ R + + K ++ + H NII Sbjct: 15 LDLQWVGSGAQGAVFLG--RFHGEEVAVKKV-RDLKET--------DIKHLRKLKHPNII 63 Query: 85 GLLNAFTPQRN---LEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGIKHLH 141 T L EF + E++ A + +D + G+ +LH Sbjct: 64 TFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWS------MGIAGGMNYLH 117 Query: 142 SAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGYT 201 IIHRDLK N+++ D +KI DFG ++ + T + APEVI + Sbjct: 118 LHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVS 177 Query: 202 ENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGT-----PSPS-----FMQRLQ 251 E VDIWS G ++ E++ G + + D + II +G+ P PS F L+ Sbjct: 178 EKVDIWSFGVVLWELLTGEIPYKDVDS----SAIIWGVGSNSLHLPVPSSCPDGFKILLR 233 Query: 252 PTVRNYVENRPRY 264 + NRP + Sbjct: 234 QCWNSKPRNRPSF 246 >2OU7-A nrPDB Length = 335 Score = 70.9 bits (172), Expect = 9e-13, Method: Compositional matrix adjust. Identities = 55/199 (27%), Positives = 91/199 (45%), Gaps = 11/199 (5%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAK-RAYREFKLMKLVNHKNIIGLLN 88 +G G D T++ A K + + H + + E + + + H++++G Sbjct: 49 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 108 Query: 89 AFTPQRNLEEFQDVYLVMELMDANLCQVI---QMDLDHDRMSYLLYQMLCGIKHLHSAGI 145 F E+ V++V+EL + + L Y L Q++ G ++LH + Sbjct: 109 FF------EDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRV 162 Query: 146 IHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVV-TRYYRAPEVILGMGYTENV 204 IHRDLK N+ + D +KI DFGLA + T Y APEV+ G++ V Sbjct: 163 IHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGHSFEV 222 Query: 205 DIWSVGCIMGEMIRGGVLF 223 D+WS+GCIM ++ G F Sbjct: 223 DVWSIGCIMYTLLVGKPPF 241 >3FME-A nrPDB Length = 290 Score = 70.9 bits (172), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 68/240 (28%), Positives = 108/240 (45%), Gaps = 32/240 (13%) Query: 26 NLRPI---GSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKL-MKLVNHK 81 +L PI G GA G+V + Q +A+K++ R N KR + + M+ V+ Sbjct: 8 DLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI-RATVNSQEQKRLLMDLDISMRTVDCP 66 Query: 82 NIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLD------HDRMSYLLYQMLC 135 + A + DV++ MELMD +L + + +D D + + ++ Sbjct: 67 FTVTFYGALFRE------GDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVK 120 Query: 136 GIKHLHSA-GIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEV 194 ++HLHS +IHRD+KPSN+++ A +K+ DFG++ + Y APE Sbjct: 121 ALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDDVAKDIDAGCKPYMAPER 180 Query: 195 I----LGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGT----PSPSF 246 I GY+ DIWS+G M E+ + FP D W +QL PSP Sbjct: 181 INPELNQKGYSVKSDIWSLGITMIEL--AILRFP----YDSWGTPFQQLKQVVEEPSPQL 234 >3GUB-A nrPDB Length = 295 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 76/309 (24%), Positives = 128/309 (41%), Gaps = 68/309 (22%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAY------REFKLMKLVNHKNI 83 +GSG +V + T A K + + + ++R RE ++K + H N+ Sbjct: 19 LGSGQFAVVKKCREKSTGLQYAAKFIKK--RRTKSSRRGVSREDIEREVSILKEIQHPNV 76 Query: 84 IGLLNAFTPQRNLEEFQDVYLVMELM-DANLCQVI--QMDLDHDRMSYLLYQMLCGIKHL 140 I L + E DV L+ EL+ L + + L + + L Q+L G+ +L Sbjct: 77 ITLHEVY------ENKTDVILIGELVAGGELFDFLAEKESLTEEEATEFLKQILNGVYYL 130 Query: 141 HSAGIIHRDLKPSNIVV----KADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVI- 195 HS I H DLKP NI++ +KI+DFGLA T + APE++ Sbjct: 131 HSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAPEIVN 190 Query: 196 ---LGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQP 252 LG+ D+WS+G I ++ G SP Q Sbjct: 191 YEPLGL----EADMWSIGVITYILLSGA----------------------SPFLGDTKQE 224 Query: 253 TVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVD 312 T+ N Y F+ D F N ++ A++ + ++LV DP++R+++ Sbjct: 225 TLANV-----SAVNYEFE----DEYFSN--------TSALAKDFIRRLLVKDPKKRMTIQ 267 Query: 313 EALKHEYIN 321 ++L+H +I Sbjct: 268 DSLQHPWIK 276 >2JDO-A nrPDB Length = 342 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 79/348 (22%), Positives = 136/348 (39%), Gaps = 61/348 (17%) Query: 27 LRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPF----QNVTHAKRAYREFKLMKLVNHKN 82 L+ +G G G V + T + A+K L + V H E ++++ H Sbjct: 15 LKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHT---VTESRVLQNTRHPF 71 Query: 83 IIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVI-----QMDLDHDRMSYLLYQMLCGI 137 + L AF L VME AN ++ + +R + +++ + Sbjct: 72 LTALKYAFQTHDRL------CFVMEY--ANGGELFFHLSRERVFTEERARFYGAEIVSAL 123 Query: 138 KHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTA---GTTFMMTPYVVTRYYRAPEV 194 ++LHS +++RD+K N+++ D +KI DFGL + G T M + T Y APEV Sbjct: 124 EYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGAT--MKTFCGTPEYLAPEV 181 Query: 195 ILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTV 254 + Y VD W +G +M EM+ G + F DH ++ E + F + L P Sbjct: 182 LEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDH----ERLFELILMEEIRFPRTLSPEA 237 Query: 255 RNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVID---------- 304 ++ + GL D Q SDA+ ++ + Sbjct: 238 KSLLA----------------GLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKK 281 Query: 305 --PEQRISVDEALKHEYINVWYDAEEVDAPAPEPYDH----SVDEREH 346 P + V + Y + + A+ + P+ YD +D+RE Sbjct: 282 LLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQREE 329 >5YV8-A nrPDB Length = 298 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 56/225 (24%), Positives = 103/225 (45%), Gaps = 36/225 (16%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRP------------------------FQNVTHA 65 IG G+ G+V AY+ A+K LS+ Q Sbjct: 21 IGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPI 80 Query: 66 KRAYREFKLMKLVNHKNIIGLLNAFT-PQRNLEEFQDVYLVMELMDANLCQVIQM--DLD 122 ++ Y+E ++K ++H N++ L+ P + +Y+V EL++ + L Sbjct: 81 EQVYQEIAILKKLDHPNVVKLVEVLDDPNED-----HLYMVFELVNQGPVMEVPTLKPLS 135 Query: 123 HDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLART-AGTTFMMT 181 D+ + ++ GI++LH IIHRD+KPSN++V D +KI DFG++ G+ +++ Sbjct: 136 EDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLS 195 Query: 182 PYVVTRYYRAPEVIL---GMGYTENVDIWSVGCIMGEMIRGGVLF 223 V T + APE + + + +D+W++G + + G F Sbjct: 196 NTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPF 240 >4J52-A nrPDB Length = 293 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 54/195 (27%), Positives = 90/195 (46%), Gaps = 11/195 (5%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAK-RAYREFKLMKLVNHKNIIGLLN 88 +G G D T++ A K + + H + + E + + + H++++G Sbjct: 22 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 81 Query: 89 AFTPQRNLEEFQDVYLVMELMDANLCQVI---QMDLDHDRMSYLLYQMLCGIKHLHSAGI 145 F E+ V++V+EL + + L Y L Q++ G ++LH + Sbjct: 82 FF------EDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRV 135 Query: 146 IHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVV-TRYYRAPEVILGMGYTENV 204 IHRDLK N+ + D +KI DFGLA + T Y APEV+ G++ V Sbjct: 136 IHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGHSFEV 195 Query: 205 DIWSVGCIMGEMIRG 219 D+WS+GCIM ++ G Sbjct: 196 DVWSIGCIMYTLLVG 210 >3TT0-A nrPDB Length = 382 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 69/235 (29%), Positives = 101/235 (42%), Gaps = 38/235 (16%) Query: 23 RYINLRPIGSGAQGIVCAAYDTITQQN-------VAIKKLSRPFQNVTHAKRA--YREFK 73 R + +P+G GA G V A ++ VA+K L + T + E + Sbjct: 70 RLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLK---SDATEKDLSDLISEME 126 Query: 74 LMKLVN-HKNIIGLLNAFT---PQRNLEEFQDVYLVMELMDA----------NLCQVIQM 119 +MK++ HKNII LL A T P + E+ + E + A N + Sbjct: 127 MMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYSYNPSHNPEE 186 Query: 120 DLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLART------ 173 L + YQ+ G+++L S IHRDL N++V D +KI DFGLAR Sbjct: 187 QLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDY 246 Query: 174 -AGTTFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGT 226 TT P + APE + YT D+WS G ++ E+ GG +PG Sbjct: 247 YKKTTNGRLPV----KWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGV 297 >3GQL-A nrPDB Length = 326 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 69/235 (29%), Positives = 101/235 (42%), Gaps = 38/235 (16%) Query: 23 RYINLRPIGSGAQGIVCAAYDTITQQN-------VAIKKLSRPFQNVTHAKRA--YREFK 73 R + +P+G GA G V A ++ VA+K L + T + E + Sbjct: 29 RLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLK---SDATEKDLSDLISEME 85 Query: 74 LMKLVN-HKNIIGLLNAFT---PQRNLEEFQDVYLVMELMDA----------NLCQVIQM 119 +MK++ HKNII LL A T P + E+ + E + A N + Sbjct: 86 MMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEE 145 Query: 120 DLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLART------ 173 L + YQ+ G+++L S IHRDL N++V D +KI DFGLAR Sbjct: 146 QLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDY 205 Query: 174 -AGTTFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGT 226 TT P + APE + YT D+WS G ++ E+ GG +PG Sbjct: 206 YKKTTNGRLPV----KWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGV 256 >2XIK-A nrPDB Length = 294 Score = 69.3 bits (168), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 55/208 (26%), Positives = 96/208 (46%), Gaps = 16/208 (7%) Query: 21 HSR------YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKL 74 HSR + L IG G+ G V D T++ VAIK + + + +E + Sbjct: 12 HSRVDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDL-EEAEDEIEDIQQEITV 70 Query: 75 MKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN--LCQVIQMDLDHDRMSYLLYQ 132 + + I ++ L +++ME + L + L+ ++ +L + Sbjct: 71 LSQCDSPYITRYFGSYLKSTKL------WIIMEYLGGGSALDLLKPGPLEETYIATILRE 124 Query: 133 MLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLA-RTAGTTFMMTPYVVTRYYRA 191 +L G+ +LHS IHRD+K +N+++ +K+ DFG+A + T +V T ++ A Sbjct: 125 ILKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMA 184 Query: 192 PEVILGMGYTENVDIWSVGCIMGEMIRG 219 PEVI Y DIWS+G E+ +G Sbjct: 185 PEVIKQSAYDFKADIWSLGITAIELAKG 212 >4D2V-A nrPDB Length = 356 Score = 69.3 bits (168), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 79/322 (24%), Positives = 135/322 (41%), Gaps = 61/322 (18%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNA 89 IG+G V A +T + VAIK + + + R E + +K + H++I L + Sbjct: 37 IGTGGFAKVKLACHILTGEMVAIKIMDKNTLG-SDLPRIKTEIEALKNLRHQHICQLYHV 95 Query: 90 FTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMS-----YLLYQMLCGIKHLHSAG 144 LE +++V+E ++ + DR+S + Q++ + ++HS G Sbjct: 96 ------LETANKIFMVLEYCPGG--ELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQG 147 Query: 145 IIHRDLKPSNIVVKADCTLKILDFGL-ARTAGTT-FMMTPYVVTRYYRAPEVILGMGYT- 201 HRDLKP N++ LK++DFGL A+ G + + Y APE+I G Y Sbjct: 148 YAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQACCGALAYAAPELIQGKSYLG 207 Query: 202 ENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENR 261 D+WS+G ++ ++ G + F KI+ R Sbjct: 208 SEADVWSMGILLYVLMCGFLPFDDDTAAALVAKIM------------------------R 243 Query: 262 PRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEYIN 321 +Y P L P+ + LL +ML +DP++RIS+ L H +I Sbjct: 244 GKYD-------VPKWLSPS------------SILLLQQMLQVDPKKRISMKNLLNHPWIM 284 Query: 322 VWYDAEEVDAPAPEPYDHSVDE 343 Y+ V+ + P+ H D+ Sbjct: 285 QDYNY-PVEWQSKNPFIHLDDD 305 >5GRN-A nrPDB Length = 356 Score = 68.6 bits (166), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 70/238 (29%), Positives = 108/238 (45%), Gaps = 48/238 (20%) Query: 28 RPIGSGAQGIVC--AAYDTITQQ---NVAIKKLSRPFQNVTHAKRAYREFKLMK-LVNHK 81 R +GSGA G V AY Q VA+K L +P + + E K+M L H Sbjct: 52 RVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKML-KPTARSSEKQALMSELKIMTHLGPHL 110 Query: 82 NIIGLLNAFT---PQRNLEEF-------------QDVYLVME---LMDANLCQVIQMDLD 122 NI+ LL A T P + E+ +D +L + ++D+ + ++ D Sbjct: 111 NIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHKKKSMLDSEVKNLLSDDNS 170 Query: 123 H-----DRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLAR----- 172 D +S+ YQ+ G++ L S +HRDL N+++ +KI DFGLAR Sbjct: 171 EGLTLLDLLSFT-YQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHD 229 Query: 173 ----TAGTTFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIR-GGVLFPG 225 + G+TF+ ++ APE I YT D+WS G ++ E+ GG +PG Sbjct: 230 SNYVSKGSTFLPVKWM------APESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPG 281 >5A46-A nrPDB Length = 386 Score = 68.6 bits (166), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 69/247 (27%), Positives = 108/247 (43%), Gaps = 39/247 (15%) Query: 23 RYINLRPIGSGAQGIVCAAYDTITQQN-------VAIKKLSRPFQNVTHAKRA--YREFK 73 R + +P+G G G V A ++ VA+K L + T + E + Sbjct: 41 RLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK---SDATEKDLSDLISEME 97 Query: 74 LMKLVN-HKNIIGLLNAFT---PQRNLEEFQDVYLVMELMDA----------NLCQVIQM 119 +MK++ HKNII LL A T P + E+ + E + A N + Sbjct: 98 MMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEE 157 Query: 120 DLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLART------ 173 L + YQ+ G+++L S IHRDL N++V D +KI DFGLAR Sbjct: 158 QLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDY 217 Query: 174 -AGTTFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQ 231 TT P + APE + YT D+WS G ++ E+ GG +PG +++ Sbjct: 218 YKKTTNGRLPV----KWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVP-VEE 272 Query: 232 WNKIIEQ 238 K++++ Sbjct: 273 LFKLLKE 279 >6HXF-B nrPDB Length = 302 Score = 68.6 bits (166), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 53/197 (26%), Positives = 91/197 (46%), Gaps = 18/197 (9%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNA 89 +G GA G V A + T A K + ++ + E +++ +H I+ LL A Sbjct: 27 LGDGAFGKVYKAKNKETGALAAAKVIET--KSEEELEDYIVEIEILATCDHPYIVKLLGA 84 Query: 90 FTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHD----RMSYLLYQMLCGIKHLHSAGI 145 + L ++++E I ++LD ++ + QML + LHS I Sbjct: 85 YYHDGKL------WIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKRI 138 Query: 146 IHRDLKPSNIVVKADCTLKILDFGL-ARTAGTTFMMTPYVVTRYYRAPEVIL-----GMG 199 IHRDLK N+++ + +++ DFG+ A+ T ++ T Y+ APEV++ Sbjct: 139 IHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTP 198 Query: 200 YTENVDIWSVGCIMGEM 216 Y DIWS+G + EM Sbjct: 199 YDYKADIWSLGITLIEM 215 >6GVJ-A nrPDB Length = 429 Score = 68.6 bits (166), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 69/240 (28%), Positives = 102/240 (42%), Gaps = 59/240 (24%) Query: 100 QDVYLVMELMDANLCQVIQMDLDHD---RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIV 156 Q +Y+VME + +L ++ D R SY ML + +H GI+H DLKP+N + Sbjct: 217 QYIYMVMECGNIDLNSWLKKKKSIDPWERKSYW-KNMLEAVHTIHQHGIVHSDLKPANFL 275 Query: 157 VKADCTLKILDFGLA---RTAGTTFMMTPYVVTRYYRAPEVILGMGYT-EN--------- 203 + D LK++DFG+A + T+ + V T Y PE I M + EN Sbjct: 276 I-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISP 334 Query: 204 -VDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENRP 262 D+WS+GCI+ M G F +II Q+ +L + E Sbjct: 335 KSDVWSLGCILYYMTYGKTPF---------QQIINQIS--------KLHAIIDPNHEIE- 376 Query: 263 RYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEYINV 322 FPD P D +++L L DP+QRIS+ E L H Y+ + Sbjct: 377 ----------FPD--IPE----------KDLQDVLKCCLKRDPKQRISIPELLAHPYVQI 414 >3TXO-A nrPDB Length = 353 Score = 68.2 bits (165), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 59/217 (27%), Positives = 99/217 (45%), Gaps = 14/217 (6%) Query: 27 LRPIGSGAQGIVCAAYDTITQQNVAIKKLSRP-FQNVTHAKRAYREFKLMKLV-NHKNII 84 +R +G G+ G V A T A+K L + + E +++ L NH + Sbjct: 28 IRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLT 87 Query: 85 GLLNAF-TPQRNLEEFQDVYLVMELMDA-NLCQVIQMD--LDHDRMSYLLYQMLCGIKHL 140 L F TP R ++ VME ++ +L IQ D R + +++ + L Sbjct: 88 QLFCCFQTPDR-------LFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFL 140 Query: 141 HSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTP-YVVTRYYRAPEVILGMG 199 H GII+RDLK N+++ + K+ DFG+ + + T + T Y APE++ M Sbjct: 141 HDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEML 200 Query: 200 YTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKII 236 Y VD W++G ++ EM+ G F + D + I+ Sbjct: 201 YGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAIL 237 >1S9I-A nrPDB Length = 354 Score = 68.2 bits (165), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 50/162 (30%), Positives = 82/162 (50%), Gaps = 11/162 (6%) Query: 70 REFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDA-NLCQVIQ--MDLDHDRM 126 RE +++ N I+G AF ++ + ME MD +L QV++ + + + Sbjct: 63 RELQVLHECNSPYIVGFYGAFYSD------GEISICMEHMDGGSLDQVLKEAKRIPEEIL 116 Query: 127 SYLLYQMLCGIKHLHSA-GIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVV 185 + +L G+ +L I+HRD+KPSNI+V + +K+ DFG++ + M +V Sbjct: 117 GKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS-MANSFVG 175 Query: 186 TRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTD 227 TR Y APE + G Y+ DIWS+G + E+ G P D Sbjct: 176 TRSYMAPERLQGTHYSVQSDIWSMGLSLVELAVGRYPIPPPD 217 >3EQC-A nrPDB Length = 360 Score = 67.8 bits (164), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 70/286 (24%), Positives = 124/286 (43%), Gaps = 53/286 (18%) Query: 70 REFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDA-NLCQVIQMD--LDHDRM 126 RE +++ N I+G AF ++ + ME MD +L QV++ + + Sbjct: 80 RELQVLHECNSPYIVGFYGAFYSD------GEISICMEHMDGGSLDQVLKKAGRIPEQIL 133 Query: 127 SYLLYQMLCGIKHLHSA-GIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVV 185 + ++ G+ +L I+HRD+KPSNI+V + +K+ DFG++ + M +V Sbjct: 134 GKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS-MANSFVG 192 Query: 186 TRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHID--------------- 230 TR Y +PE + G Y+ DIWS+G + EM G P D + Sbjct: 193 TRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAE 252 Query: 231 ------QWNKIIEQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQ 284 + + + G S M + + +Y+ N P P G+F Sbjct: 253 TPPRPRTPGRPLNKFGMDSRPPMAIFE--LLDYIVNEPPPK-------LPSGVF------ 297 Query: 285 NSRRKASDARNLLSKMLVIDPEQRISVDEALKHEYINVWYDAEEVD 330 + + ++ ++K L+ +P +R + + + H +I DAEEVD Sbjct: 298 -----SLEFQDFVNKCLIKNPAERADLKQLMVHAFIK-RSDAEEVD 337 >3HDN-A nrPDB Length = 373 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 59/223 (26%), Positives = 100/223 (44%), Gaps = 22/223 (9%) Query: 27 LRPIGSGAQGIVCAAYDTITQQNVAIKKL-SRPFQNVTHAKRAYREFK-LMKLVNHKNII 84 L+ IG G+ G V A + A+K L + K E L+K V H ++ Sbjct: 43 LKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLV 102 Query: 85 GLLNAFTPQRNLEEFQDVYLVMELMDAN-LCQVIQMD--LDHDRMSYLLYQMLCGIKHLH 141 GL +F L Y V++ ++ L +Q + R + ++ + +LH Sbjct: 103 GLHFSFQTADKL------YFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLH 156 Query: 142 SAGIIHRDLKPSNIVVKADCTLKILDFGLAR------TAGTTFMMTPYVVTRYYRAPEVI 195 S I++RDLKP NI++ + + + DFGL + + +TF TP Y APEV+ Sbjct: 157 SLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTP-----EYLAPEVL 211 Query: 196 LGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQ 238 Y VD W +G ++ EM+ G F + + ++ I+ + Sbjct: 212 HKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNK 254 >4XCU-A nrPDB Length = 300 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 68/231 (29%), Positives = 99/231 (42%), Gaps = 41/231 (17%) Query: 23 RYINLRPIGSGAQGIVCAA-------YDTITQQNVAIKKLSRPFQNVTHAKRA--YREFK 73 R + +P+G G G V A VA+K L N + A E + Sbjct: 18 RLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLK---DNASDKDLADLVSEME 74 Query: 74 LMKLVN-HKNIIGLLNAFTPQRNLEEFQDVYLVMELM-DANLCQVIQM---------DLD 122 +MKL+ HKNII LL T + L Y+++E NL + ++ L Sbjct: 75 VMKLIGRHKNIINLLGVCTQEGPL------YVIVECAAKGNLREFLRARRPPGSSEGPLS 128 Query: 123 HDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTA-------G 175 + YQ+ G+++L S IHRDL N++V D +KI DFGLAR Sbjct: 129 FPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKK 188 Query: 176 TTFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIR-GGVLFPG 225 T+ P + APE + YT D+WS G ++ E+ GG +PG Sbjct: 189 TSNGRLPV----KWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPG 235 >5KCV-A nrPDB Length = 460 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 61/225 (27%), Positives = 93/225 (41%), Gaps = 56/225 (24%) Query: 121 LDHDRMSYLLYQMLCGIKHLHS-AGIIHRDLKPSNIVVKADCTLKILDFGLARTA---GT 176 DR + +++ + +LHS +++RDLK N+++ D +KI DFGL + G Sbjct: 259 FSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGA 318 Query: 177 TFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKII 236 T M + T Y APEV+ Y VD W +G +M EM+ G + F DH K+ Sbjct: 319 T--MKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDH----EKLF 372 Query: 237 EQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNL 296 E + L +R FP L P +A++L Sbjct: 373 ELI----------LMEEIR-----------------FPRTLGP------------EAKSL 393 Query: 297 LSKMLVIDPEQRIS-----VDEALKHEYIN--VWYDAEEVDAPAP 334 LS +L DP+QR+ E ++H + VW E P Sbjct: 394 LSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPP 438 >3TKU-A nrPDB Length = 433 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 65/230 (28%), Positives = 111/230 (48%), Gaps = 17/230 (7%) Query: 27 LRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRA-YREFKLMKLVNH--KNI 83 ++ IG GA G V T++ A+K L++ ++ + A+ A +RE + + LVN + I Sbjct: 95 IKVIGRGAFGEVAVVKMKNTERIYAMKILNK-WEMLKRAETACFREERDV-LVNGDCQWI 152 Query: 84 IGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGIKHLHSA 143 L AF + +L D Y+ +L+ L + L D + + +M+ I +H Sbjct: 153 TALHYAFQDENHLYLVMDYYVGGDLL--TLLSKFEDKLPEDMARFYIGEMVLAIDSIHQL 210 Query: 144 GIIHRDLKPSNIVVKADCTLKILDFG--LARTAGTTFMMTPYVVTRYYRAPEVIL----G 197 +HRD+KP N+++ + +++ DFG L T + V T Y +PE++ G Sbjct: 211 HYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQAMEDG 270 Query: 198 MG-YTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKII---EQLGTPS 243 MG Y D WS+G M EM+ G F ++ + KI+ E+ PS Sbjct: 271 MGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPS 320 >2R2P-A nrPDB Length = 295 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 58/208 (27%), Positives = 88/208 (42%), Gaps = 26/208 (12%) Query: 28 RPIGSGAQGIVCAAYDTITQQN---VAIKKLSRPFQNVTHAKRAYREF----KLMKLVNH 80 R IG+G G VC+ + + VAIK L V + ++ R+F +M +H Sbjct: 28 RVIGAGEFGEVCSGRLKLPGKRELPVAIKTL-----KVGYTEKQRRDFLGEASIMGQFDH 82 Query: 81 KNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQML----CG 136 NII L T + V +V E M+ D L ML G Sbjct: 83 PNIIHLEGVVTKSK------PVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGISAG 136 Query: 137 IKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLART----AGTTFMMTPYVVTRYYRAP 192 +K+L G +HRDL NI++ ++ K+ DFGL+R + + + AP Sbjct: 137 MKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAP 196 Query: 193 EVILGMGYTENVDIWSVGCIMGEMIRGG 220 E I +T D+WS G +M E++ G Sbjct: 197 EAIAFRKFTSASDVWSYGIVMWEVVSYG 224 >3DKO-A nrPDB Length = 318 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 57/208 (27%), Positives = 90/208 (43%), Gaps = 26/208 (12%) Query: 28 RPIGSGAQGIVCAAYDTITQQN---VAIKKLSRPFQNVTHAKRAYREF----KLMKLVNH 80 R IG+G G VC+ + + VAIK L V + ++ R+F +M +H Sbjct: 49 RVIGAGEFGEVCSGRLKLPGKRDVAVAIKTL-----KVGYTEKQRRDFLCEASIMGQFDH 103 Query: 81 KNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQML----CG 136 N++ L T + V +V+E M+ D L ML G Sbjct: 104 PNVVHLEGVVT------RGKPVMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGIAAG 157 Query: 137 IKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLART----AGTTFMMTPYVVTRYYRAP 192 +++L G +HRDL NI+V ++ K+ DFGL+R + T + + AP Sbjct: 158 MRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAP 217 Query: 193 EVILGMGYTENVDIWSVGCIMGEMIRGG 220 E I +T D+WS G +M E++ G Sbjct: 218 EAIQYRKFTSASDVWSYGIVMWEVMSYG 245 >3HMP-A nrPDB Length = 342 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 69/240 (28%), Positives = 102/240 (42%), Gaps = 59/240 (24%) Query: 100 QDVYLVMELMDANLCQVIQMDLDHD---RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIV 156 Q +Y+VME + +L ++ D R SY ML + +H GI+H DLKP+N + Sbjct: 129 QYIYMVMECGNIDLNSWLKKKKSIDPWERKSYW-KNMLEAVHTIHQHGIVHSDLKPANFL 187 Query: 157 VKADCTLKILDFGLA---RTAGTTFMMTPYVVTRYYRAPEVILGMGYT-EN--------- 203 + D LK++DFG+A + T+ + V T Y PE I M + EN Sbjct: 188 I-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISP 246 Query: 204 -VDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENRP 262 D+WS+GCI+ M G F +II Q+ +L + E Sbjct: 247 KSDVWSLGCILYYMTYGKTPF---------QQIINQIS--------KLHAIIDPNHEIE- 288 Query: 263 RYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEYINV 322 FPD P D +++L L DP+QRIS+ E L H Y+ + Sbjct: 289 ----------FPD--IPE----------KDLQDVLKCCLKRDPKQRISIPELLAHPYVQI 326 >5KKR-C nrPDB Length = 395 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 68/277 (24%), Positives = 124/277 (44%), Gaps = 35/277 (12%) Query: 70 REFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDA-NLCQVIQMD--LDHDRM 126 RE +++ N I+G AF ++ + ME MD +L QV++ + + Sbjct: 115 RELQVLHECNSPYIVGFYGAFYSD------GEISICMEHMDGGSLDQVLKKAGRIPEQIL 168 Query: 127 SYLLYQMLCGIKHLHSA-GIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVV 185 + ++ G+ +L I+HRD+KPSNI+V + +K+ DFG++ M +V Sbjct: 169 GKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL-IDSMANSFVG 227 Query: 186 TRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHID---QWNKIIEQLGTP 242 TR Y +PE + G Y+ DIWS+G + EM G P D + + +E Sbjct: 228 TRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAE 287 Query: 243 SPSFMQRLQPTVRNY-VENRPRYTGYSF--------DRLFPDGLFPNDNNQNSRRKASDA 293 +P + + +Y +++RP + P +F + + Sbjct: 288 TPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSAVF-----------SLEF 336 Query: 294 RNLLSKMLVIDPEQRISVDEALKHEYINVWYDAEEVD 330 ++ ++K L+ +P +R + + + H +I DAEEVD Sbjct: 337 QDFVNKCLIKNPAERADLKQLMVHAFIK-RSDAEEVD 372 >4WUA-A nrPDB Length = 401 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 92/384 (23%), Positives = 158/384 (41%), Gaps = 83/384 (21%) Query: 8 HYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKR 67 ++ V++GD + RY +R +G G V ++D ++ VA+K + + + Sbjct: 30 YHLVKIGDL---FNGRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEH---YTET 83 Query: 68 AYREFKLMKLV--------NHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVI-- 117 A E +L+K V N + ++ LL+ F + + + +V E++ +L + I Sbjct: 84 ALDEIRLLKSVRNSDPNDPNREMVVQLLDDF--KISGVNGTHICMVFEVLGHHLLKWIIK 141 Query: 118 --QMDLDHDRMSYLLYQMLCGIKHLHS-AGIIHRDLKPSNIVVK----------ADCT-- 162 L + ++ Q+L G+ +LH+ IIH D+KP NI++ A+ T Sbjct: 142 SNYQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEW 201 Query: 163 -------------------------------------LKILDFGLARTAGTTFMMTPYVV 185 +KI D G A F T + Sbjct: 202 QRSGAPPPSGSAVSTAPATAGNFLVNPLEPKNAEKLKVKIADLGNACWVHKHF--TEDIQ 259 Query: 186 TRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLF---PGTDHI---DQWNKIIEQL 239 TR YR+ EV++G GY DIWS C+ E+ G LF G ++ D IIE L Sbjct: 260 TRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELL 319 Query: 240 GTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFP--NDNNQNSRRKASDARNLL 297 G P + + + + +L P GLF + + S+ +A+ + L Sbjct: 320 GK-VPRKLIVAGKYSKEFFTKKGDLK--HITKLKPWGLFEVLVEKYEWSQEEAAGFTDFL 376 Query: 298 SKMLVIDPEQRISVDEALKHEYIN 321 ML + PE+R + E L+H ++N Sbjct: 377 LPMLELIPEKRATAAECLRHPWLN 400 >4IDT-A nrPDB Length = 356 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 61/202 (30%), Positives = 94/202 (46%), Gaps = 27/202 (13%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKL--VNHKNIIGLL 87 +G G+ G V D T A+KK+ +R +LM + I+ L Sbjct: 82 LGRGSFGEVHRMEDKQTGFQCAVKKVRL---------EVFRAEELMACAGLTSPRIVPLY 132 Query: 88 NAFTPQRNLEEFQDVYLVMELMDA-NLCQVI--QMDLDHDRMSYLLYQMLCGIKHLHSAG 144 A + E V + MEL++ +L Q++ Q L DR Y L Q L G+++LHS Sbjct: 133 GA------VREGPWVNIFMELLEGGSLGQLVKEQGCLPEDRALYYLGQALEGLEYLHSRR 186 Query: 145 IIHRDLKPSNIVVKADCT-LKILDFGLART-----AGTTFMMTPYVV-TRYYRAPEVILG 197 I+H D+K N+++ +D + + DFG A G + Y+ T + APEV+LG Sbjct: 187 ILHGDVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKDLLTGDYIPGTETHMAPEVVLG 246 Query: 198 MGYTENVDIWSVGCIMGEMIRG 219 VD+WS C+M M+ G Sbjct: 247 RSCDAKVDVWSSCCMMLHMLNG 268 >3PFQ-A nrPDB Length = 674 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 45/147 (30%), Positives = 73/147 (49%), Gaps = 18/147 (12%) Query: 102 VYLVMELMDAN-----LCQVIQMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIV 156 +Y VME ++ + QV + H + ++ G+ L S GII+RDLK N++ Sbjct: 417 LYFVMEYVNGGDLMYHIQQVGRFKEPH--AVFYAAEIAIGLFFLQSKGIIYRDLKLDNVM 474 Query: 157 VKADCTLKILDFGLAR------TAGTTFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVG 210 + ++ +KI DFG+ + TF TP Y APE+I Y ++VD W+ G Sbjct: 475 LDSEGHIKIADFGMCKENIWDGVTTKTFCGTPD-----YIAPEIIAYQPYGKSVDWWAFG 529 Query: 211 CIMGEMIRGGVLFPGTDHIDQWNKIIE 237 ++ EM+ G F G D + + I+E Sbjct: 530 VLLYEMLAGQAPFEGEDEDELFQSIME 556 >3A8W-A nrPDB Length = 345 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 54/206 (26%), Positives = 94/206 (45%), Gaps = 26/206 (12%) Query: 27 LRPIGSGAQGIVC----AAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKN 82 LR IG G+ V D I V K+L +++ + F+ + NH Sbjct: 14 LRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFE--QASNHPF 71 Query: 83 IIGLLNAFTPQRNLEEFQDVYLVMELM---DANLCQVIQMDLDHDRMSYLLYQMLCGIKH 139 ++GL + F + L + V+E + D Q L + + ++ + + Sbjct: 72 LVGLHSCFQTESRL------FFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNY 125 Query: 140 LHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTA------GTTFMMTPYVVTRYYRAPE 193 LH GII+RDLK N+++ ++ +K+ D+G+ + +TF TP Y APE Sbjct: 126 LHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTP-----NYIAPE 180 Query: 194 VILGMGYTENVDIWSVGCIMGEMIRG 219 ++ G Y +VD W++G +M EM+ G Sbjct: 181 ILRGEDYGFSVDWWALGVLMFEMMAG 206 >3G0E-A nrPDB Length = 336 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 71/240 (29%), Positives = 105/240 (43%), Gaps = 34/240 (14%) Query: 28 RPIGSGAQGIV--CAAYDTI---TQQNVAIKKLSRPFQNVTHAKRAYREFKLMK-LVNHK 81 + +G+GA G V AY I VA+K L +P ++T + E K++ L NH Sbjct: 52 KTLGAGAFGKVVEATAYGLIKSDAAMTVAVKML-KPSAHLTEREALMSELKVLSYLGNHM 110 Query: 82 NIIGLLNAFT---PQRNLEEF-------------QDVYLVMELMDANLCQVIQMDLDHDR 125 NI+ LL A T P + E+ +D ++ + A + D Sbjct: 111 NIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKTSPAIMEDDELALDLEDL 170 Query: 126 MSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVV 185 +S+ YQ+ G+ L S IHRDL NI++ KI DFGLAR + YVV Sbjct: 171 LSFS-YQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKND---SNYVV 226 Query: 186 TRYYR------APEVILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQWNKIIEQ 238 R APE I YT D+WS G + E+ G +PG ++ K+I++ Sbjct: 227 KGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKE 286 >2I0E-A nrPDB Length = 353 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 45/147 (30%), Positives = 73/147 (49%), Gaps = 18/147 (12%) Query: 102 VYLVMELMDAN-----LCQVIQMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIV 156 +Y VME ++ + QV + H + ++ G+ L S GII+RDLK N++ Sbjct: 96 LYFVMEYVNGGDLMYHIQQVGRFKEPH--AVFYAAEIAIGLFFLQSKGIIYRDLKLDNVM 153 Query: 157 VKADCTLKILDFGLAR------TAGTTFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVG 210 + ++ +KI DFG+ + TF TP Y APE+I Y ++VD W+ G Sbjct: 154 LDSEGHIKIADFGMCKENIWDGVTTKTFCGTPD-----YIAPEIIAYQPYGKSVDWWAFG 208 Query: 211 CIMGEMIRGGVLFPGTDHIDQWNKIIE 237 ++ EM+ G F G D + + I+E Sbjct: 209 VLLYEMLAGQAPFEGEDEDELFQSIME 235 >3MV5-A nrPDB Length = 342 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 59/214 (27%), Positives = 91/214 (42%), Gaps = 56/214 (26%) Query: 121 LDHDRMSYLLYQMLCGIKHLHS-AGIIHRDLKPSNIVVKADCTLKILDFGLARTA---GT 176 DR + +++ + +LHS +++RDLK N+++ D +KI DFGL + G Sbjct: 107 FSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGA 166 Query: 177 TFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKII 236 T M + T Y APEV+ Y VD W +G +M EM+ G + F DH K+ Sbjct: 167 T--MKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDH----EKLF 220 Query: 237 EQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNL 296 E + L +R FP L P +A++L Sbjct: 221 ELI----------LMEEIR-----------------FPRTLGP------------EAKSL 241 Query: 297 LSKMLVIDPEQRIS-----VDEALKHEYIN--VW 323 LS +L DP+QR+ E ++H + VW Sbjct: 242 LSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVW 275 >3KUL-B nrPDB Length = 325 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 58/206 (28%), Positives = 85/206 (41%), Gaps = 26/206 (12%) Query: 30 IGSGAQGIVCAAYDTITQQN---VAIKKLSRPFQNVTHAKRAYREF----KLMKLVNHKN 82 IGSG G VC + Q VAIK L + +R R+F +M +H N Sbjct: 57 IGSGDSGEVCYGRLRVPGQRDVPVAIKAL-----KAGYTERQRRDFLSEASIMGQFDHPN 111 Query: 83 IIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQML----CGIK 138 II L T R +V E M+ D L ML G++ Sbjct: 112 IIRLEGVVTRGRL------AMIVTEYMENGSLDTFLRTHDGQFTIMQLVGMLRGVGAGMR 165 Query: 139 HLHSAGIIHRDLKPSNIVVKADCTLKILDFGLART----AGTTFMMTPYVVTRYYRAPEV 194 +L G +HRDL N++V ++ K+ DFGL+R + T + + APE Sbjct: 166 YLSDLGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTAPEA 225 Query: 195 ILGMGYTENVDIWSVGCIMGEMIRGG 220 I ++ D+WS G +M E++ G Sbjct: 226 IAFRTFSSASDVWSFGVVMWEVLAYG 251 >5AP3-A nrPDB Length = 313 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 69/240 (28%), Positives = 104/240 (43%), Gaps = 59/240 (24%) Query: 100 QDVYLVMELMDANLCQVIQMDLDHD---RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIV 156 Q +Y+VME + +L ++ D R SY ML + +H GI+H DLKP+N + Sbjct: 101 QYIYMVMECGNIDLNGWLKKKKSIDPWERKSYW-KNMLEAVHTIHQHGIVHSDLKPANFL 159 Query: 157 VKADCTLKILDFGLA---RTAGTTFMMTPYVVTRYYRAPEVILGMGYT-EN--------- 203 + D LK++DFG+A + T+ + V T Y PE I M + EN Sbjct: 160 I-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISP 218 Query: 204 -VDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENRP 262 D+WS+GCI+ M G F +II Q+ +L + P Sbjct: 219 KSDVWSLGCILYYMTYGKTPF---------QQIINQIS--------KLHAII------DP 255 Query: 263 RYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEYINV 322 + + FPD P D +++L L DP+QRIS+ E L H Y+ + Sbjct: 256 NH-----EIEFPD--IPE----------KDLQDVLKCCLKRDPKQRISIPELLAHPYVQI 298 >6HV0-A nrPDB Length = 416 Score = 65.9 bits (159), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 88/309 (28%), Positives = 132/309 (42%), Gaps = 71/309 (22%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKK-LSRPFQNVTHAKRAYREFKLMKLVN-HKNIIGLL 87 +G GA+G + ++VA+K+ L F A RE +L++ + H N+I Sbjct: 16 LGHGAEGTI-VYRGMFDNRDVAVKRILPECFSF------ADREVQLLRESDEHPNVI--- 65 Query: 88 NAFTPQRNLEEFQDVYLVMELMDANLCQVI-QMDLDHDRMS--YLLYQMLCGIKHLHSAG 144 F +++ +FQ Y+ +EL A L + + Q D H + LL Q G+ HLHS Sbjct: 66 RYFCTEKD-RQFQ--YIAIELCAATLQEYVEQKDFAHLGLEPITLLQQTTSGLAHLHSLN 122 Query: 145 IIHRDLKPSNIVVK---ADCTLK--ILDFGLARTAGT---TFMMTPYVV-TRYYRAPEVI 195 I+HRDLKP NI++ A +K I DFGL + +F V T + APE + Sbjct: 123 IVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPE-M 181 Query: 196 LGMGYTEN----VDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQ 251 L EN VDI+S GC+ +I G S F + LQ Sbjct: 182 LSEDCKENPTYTVDIFSAGCVFYYVISEG----------------------SHPFGKSLQ 219 Query: 252 PTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISV 311 + S D L P+ + + AR L+ KM+ +DP++R S Sbjct: 220 RQANILL------GACSLDCLHPE-----------KHEDVIARELIEKMIAMDPQKRPSA 262 Query: 312 DEALKHEYI 320 LKH + Sbjct: 263 KHVLKHPFF 271 >3LLT-A nrPDB Length = 360 Score = 65.9 bits (159), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 59/227 (25%), Positives = 100/227 (44%), Gaps = 50/227 (22%) Query: 132 QMLCGIKHLHSAGIIHRDLKPSNIVV-------------------------KADCTLKIL 166 ++L + +L + H DLKP NI++ +K++ Sbjct: 145 EILKALNYLRKMSLTHTDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRTKSTGIKLI 204 Query: 167 DFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGT 226 DFG A T + + + + TR YRAPEVIL +G+ + D+WS GC++ E+ G +LF Sbjct: 205 DFGCA-TFKSDYHGS-IINTRQYRAPEVILNLGWDVSSDMWSFGCVLAELYTGSLLFRTH 262 Query: 227 DHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRL-FPDGLFPNDNNQN 285 +H++ ++E + P P M L + N +Y +L +P+ N ++ N Sbjct: 263 EHMEHL-AMMESIIQPIPKNM--LYEATKT---NGSKYVNKDELKLAWPE----NASSIN 312 Query: 286 SRRKASDAR------------NLLSKMLVIDPEQRISVDEALKHEYI 320 S + + L +L IDP R S E LKH+++ Sbjct: 313 SIKHVKKCLPLYKIIKHELFCDFLYSILQIDPTLRPSPAELLKHKFL 359 >4AN9-A nrPDB Length = 301 Score = 65.9 bits (159), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 67/265 (25%), Positives = 117/265 (44%), Gaps = 53/265 (20%) Query: 70 REFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDA-NLCQVIQMD--LDHDRM 126 RE +++ N I+G AF ++ + ME MD +L QV++ + + Sbjct: 56 RELQVLHECNSPYIVGFYGAFYSD------GEISICMEHMDGGSLDQVLKKAGRIPEQIL 109 Query: 127 SYLLYQMLCGIKHLHSA-GIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVV 185 + ++ G+ +L I+HRD+KPSNI+V + +K+ DFG++ M +V Sbjct: 110 GKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL-IDEMANEFVG 168 Query: 186 TRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPS 245 TR Y +PE + G Y+ DIWS+G + EM G +P P + Sbjct: 169 TRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVG--RYP----------------RPPMA 210 Query: 246 FMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDP 305 + L +Y+ N P P +F + + ++ ++K L+ +P Sbjct: 211 IFELL-----DYIVNEPPPK-------LPSAVF-----------SLEFQDFVNKCLIKNP 247 Query: 306 EQRISVDEALKHEYINVWYDAEEVD 330 +R + + + H +I DAEEVD Sbjct: 248 AERADLKQLMVHAFIK-RSDAEEVD 271 >3LM0-A nrPDB Length = 327 Score = 65.9 bits (159), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 76/332 (22%), Positives = 136/332 (40%), Gaps = 60/332 (18%) Query: 28 RPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLL 87 + +G G +V T Q A K L + + E +++L K+ ++ Sbjct: 35 KELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELA--KSCPRVI 92 Query: 88 NAFTPQRNLEEFQDVYLVMELMDA----NLC--QVIQMDLDHDRMSYLLYQMLCGIKHLH 141 N N E + L++E +LC ++ +M ++D + L+ Q+L G+ +LH Sbjct: 93 NLHEVYENTSE---IILILEYAAGGEIFSLCLPELAEMVSENDVIR-LIKQILEGVYYLH 148 Query: 142 SAGIIHRDLKPSNIVVKADCTL---KILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGM 198 I+H DLKP NI++ + L KI+DFG++R G + + T Y APE++ Sbjct: 149 QNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACELREIMGTPEYLAPEILNYD 208 Query: 199 GYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYV 258 T D+W++G I ++ F G D+ Q T N Sbjct: 209 PITTATDMWNIGIIAYMLLTHTSPFVGEDN----------------------QETYLNIS 246 Query: 259 ENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHE 318 + Y+ +F + + A + + +LV +PE+R + + L H Sbjct: 247 QVNVDYSEETFSSV-----------------SQLATDFIQSLLVKNPEKRPTAEICLSHS 289 Query: 319 YINVW-----YDAEEVDAPAPEPYDHSVDERE 345 ++ W + EE + + + DHSV E Sbjct: 290 WLQQWDFENLFHPEETSS-SSQTQDHSVRSSE 320 >2J0K-A nrPDB Length = 656 Score = 65.9 bits (159), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 70/265 (26%), Positives = 115/265 (43%), Gaps = 24/265 (9%) Query: 17 NFTIHSRYINL-RPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTH---AKRAYREF 72 ++ I I L R IG G G V ++ +N A+ + +N T ++ +E Sbjct: 384 DYEIQRERIELGRCIGEGQFGDVHQGI-YMSPENPAMAVAIKTCKNCTSDSVREKFLQEA 442 Query: 73 KLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDA----NLCQVIQMDLDHDRMSY 128 M+ +H +I+ L+ T V+++MEL + QV + LD + Sbjct: 443 LTMRQFDHPHIVKLIGVITEN-------PVWIIMELCTLGELRSFLQVRKFSLDLASLIL 495 Query: 129 LLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLAR--TAGTTFMMTPYVVT 186 YQ+ + +L S +HRD+ N++V A +K+ DFGL+R T + + + Sbjct: 496 YAYQLSTALAYLESKRFVHRDIAARNVLVSATDCVKLGDFGLSRYMEDSTYYKASKGKLP 555 Query: 187 RYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVL-FPGTDHIDQWNKII--EQLGTP- 242 + APE I +T D+W G M E++ GV F G + D +I E+L P Sbjct: 556 IKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPP 615 Query: 243 -SPSFMQRLQPTVRNY-VENRPRYT 265 P + L Y RPR+T Sbjct: 616 NCPPTLYSLMTKCWAYDPSRRPRFT 640 >2ZMD-A nrPDB Length = 390 Score = 65.9 bits (159), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 68/240 (28%), Positives = 103/240 (42%), Gaps = 59/240 (24%) Query: 100 QDVYLVMELMDANLCQVIQMDLDHD---RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIV 156 Q +Y+VME + +L ++ D R SY ML + +H GI+H DLKP+N + Sbjct: 129 QYIYMVMECGNIDLNSWLKKKKSIDPWERKSYW-KNMLEAVHTIHQHGIVHSDLKPANFL 187 Query: 157 VKADCTLKILDFGLA---RTAGTTFMMTPYVVTRYYRAPEVILGMGYT-EN--------- 203 + D LK++DFG+A + T+ + V Y PE I M + EN Sbjct: 188 I-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGAVNYMPPEAIKDMSSSRENGKSKSKISP 246 Query: 204 -VDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENRP 262 D+WS+GCI+ M G F +II Q+ +L + P Sbjct: 247 KSDVWSLGCILYYMTYGKTPF---------QQIINQIS--------KLHAII------DP 283 Query: 263 RYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEYINV 322 + + FPD P D +++L L DP+QRIS+ E L H Y+ + Sbjct: 284 NH-----EIEFPD--IPE----------KDLQDVLKCCLKRDPKQRISIPELLAHPYVQI 326 >4PL5-B nrPDB Length = 435 Score = 65.5 bits (158), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 84/308 (27%), Positives = 129/308 (41%), Gaps = 69/308 (22%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKK-LSRPFQNVTHAKRAYREFKLMKLVN-HKNIIGLL 87 +G GA+G + ++VA+K+ L F A RE +L++ + H N+I Sbjct: 35 LGHGAEGTIVYK-GMFDNRDVAVKRILPECFSF------ADREVQLLRESDEHPNVI--- 84 Query: 88 NAFTPQRNLEEFQDVYLVMELMDANLCQVI-QMDLDHDRMS--YLLYQMLCGIKHLHSAG 144 F +++ +FQ Y+ +EL A L + + Q D H + LL+Q G+ HLHS Sbjct: 85 RYFCTEKD-RQFQ--YIAIELCAATLQEYVEQKDFAHLGLEPITLLHQTTSGLAHLHSLN 141 Query: 145 IIHRDLKPSNIVVK---ADCTLK--ILDFGLARTAGT---TFMMTPYVV-TRYYRAPEVI 195 I+HRDLKP NI++ A +K I DFGL + +F V T + APE++ Sbjct: 142 IVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEML 201 Query: 196 ---LGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQP 252 T VDI+S GC+ +I G G Q N ++ Sbjct: 202 SEDCKDNPTYTVDIFSAGCVFYYVISEGYHPFGKSLQRQANILL---------------- 245 Query: 253 TVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVD 312 G D + + + AR L+ KM+ +DP+QR S Sbjct: 246 -----------------------GACNLDCFHSDKHEDVIARELIEKMIAMDPQQRPSAK 282 Query: 313 EALKHEYI 320 LKH + Sbjct: 283 HVLKHPFF 290 >4RA4-A nrPDB Length = 355 Score = 65.5 bits (158), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 45/145 (31%), Positives = 73/145 (50%), Gaps = 14/145 (9%) Query: 102 VYLVMELMDA-NLCQVIQM--DLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK 158 +Y VME ++ +L IQ + + ++ G+ LH GII+RDLK N+++ Sbjct: 96 LYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLD 155 Query: 159 ADCTLKILDFGLAR------TAGTTFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCI 212 ++ +KI DFG+ + TF TP Y APE+I Y ++VD W+ G + Sbjct: 156 SEGHIKIADFGMCKEHMMDGVTTRTFCGTP-----DYIAPEIIAYQPYGKSVDWWAYGVL 210 Query: 213 MGEMIRGGVLFPGTDHIDQWNKIIE 237 + EM+ G F G D + + I+E Sbjct: 211 LYEMLAGQPPFDGEDEDELFQSIME 235 >4AW2-A nrPDB Length = 437 Score = 65.5 bits (158), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 63/220 (28%), Positives = 102/220 (46%), Gaps = 14/220 (6%) Query: 27 LRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRA-YREFKLMKLVN--HKNI 83 L+ IG GA G V + A+K L++ ++ + A+ A +RE + + LVN K I Sbjct: 79 LKVIGRGAFGEVAVVKLKNADKVFAMKILNK-WEMLKRAETACFREERDV-LVNGDSKWI 136 Query: 84 IGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGIKHLHSA 143 L AF NL D Y+ +L+ L + L + + L +M+ I +H Sbjct: 137 TTLHYAFQDDNNLYLVMDYYVGGDLL--TLLSKFEDRLPEEMARFYLAEMVIAIDSVHQL 194 Query: 144 GIIHRDLKPSNIVVKADCTLKILDFG--LARTAGTTFMMTPYVVTRYYRAPEVILGMG-- 199 +HRD+KP NI++ + +++ DFG L T + V T Y +PE++ M Sbjct: 195 HYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMEGG 254 Query: 200 ---YTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKII 236 Y D WS+G M EM+ G F ++ + KI+ Sbjct: 255 KGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIM 294 >1VZO-A nrPDB Length = 355 Score = 65.5 bits (158), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 63/269 (23%), Positives = 124/269 (46%), Gaps = 19/269 (7%) Query: 1 MTTAQHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIV-----CAAYDTITQQNVAIKKL 55 + TA + +VG NF + L+ +G+GA G V + +DT + + K Sbjct: 39 LRTANLTGHAEKVGIENFEL------LKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKK 92 Query: 56 SRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLN-AFTPQRNLEEFQDVYLVMELMDANLC 114 + Q + E ++++ + + L+ AF + L D EL +L Sbjct: 93 ATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELF-THLS 151 Query: 115 QVIQMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLAR-- 172 Q + +H+ Y+ +++ ++HLH GII+RD+K NI++ ++ + + DFGL++ Sbjct: 152 QRERFT-EHEVQIYV-GEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEF 209 Query: 173 TAGTTFMMTPYVVTRYYRAPEVILG--MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHID 230 A T + T Y AP+++ G G+ + VD WS+G +M E++ G F + Sbjct: 210 VADETERAYDFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKN 269 Query: 231 QWNKIIEQLGTPSPSFMQRLQPTVRNYVE 259 +I ++ P + Q + ++ ++ Sbjct: 270 SQAEISRRILKSEPPYPQEMSALAKDLIQ 298 >6GQK-A nrPDB Length = 328 Score = 65.1 bits (157), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 64/236 (27%), Positives = 106/236 (44%), Gaps = 28/236 (11%) Query: 28 RPIGSGAQG-IVCAAYDTITQQNVAIK---KLSRPFQNVTHAKRAYREFKLMK-LVNHKN 82 + +G+GA G +V A + + + A+ K+ +P + T + E K++ L NH+N Sbjct: 47 KTLGAGAFGKVVEATAQGLIKSDAAMTVAVKMLKPSAHSTEREALMSELKVLSYLGNHEN 106 Query: 83 IIGLLNAFT---PQRNLEEF-------------QDVYLVMELMDANLCQVIQMDLDHDRM 126 I+ LL A T P + E+ +D ++ ++ +L + + L+H + Sbjct: 107 IVNLLGACTHGGPTLVITEYCCYGDLLNFLRRKRDEFVPYKVAPEDLYKDF-LTLEH--L 163 Query: 127 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVT 186 YQ+ G+ L S IHRDL NI++ KI DFGLAR Sbjct: 164 LSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGNITKICDFGLARDIKNDSNYVDKGNA 223 Query: 187 RY---YRAPEVILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQWNKIIEQ 238 R + APE I YT D+WS G + E+ G +PG ++ K+I++ Sbjct: 224 RLPVKWMAPESIFNSVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKE 279 >4G3E-A nrPDB Length = 352 Score = 65.1 bits (157), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 47/128 (36%), Positives = 71/128 (55%), Gaps = 10/128 (7%) Query: 102 VYLVMELMDA-NLCQVI-QMD-LDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK 158 V + MEL++ +L Q+I QM L DR Y L Q L G+++LH+ I+H D+K N+++ Sbjct: 141 VNIFMELLEGGSLGQLIKQMGCLPEDRALYYLGQALEGLEYLHTRRILHGDVKADNVLLS 200 Query: 159 ADCTLKIL-DFGLART-----AGTTFMMTPYVV-TRYYRAPEVILGMGYTENVDIWSVGC 211 +D + L DFG A G + + Y+ T + APEV++G VDIWS C Sbjct: 201 SDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAPEVVMGKPCDAKVDIWSSCC 260 Query: 212 IMGEMIRG 219 +M M+ G Sbjct: 261 MMLHMLNG 268 >3ALO-A nrPDB Length = 327 Score = 64.7 bits (156), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 64/267 (23%), Positives = 108/267 (40%), Gaps = 40/267 (14%) Query: 26 NLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIG 85 +L IG GA G V + Q +A+K++ + +M+ + I+ Sbjct: 26 DLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQ 85 Query: 86 LLNAFTPQRNLEEFQDVYLVMELMDANLCQ-------VIQMDLDHDRMSYLLYQMLCGIK 138 A + D ++ MELM + + V+ + + + + + + Sbjct: 86 FYGALFRE------GDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALN 139 Query: 139 HL-HSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVI-- 195 HL + IIHRD+KPSNI++ +K+ DFG++ + T R Y APE I Sbjct: 140 HLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDP 199 Query: 196 --LGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQL-----GTP------ 242 GY D+WS+G + E+ G +P +WN + +QL G P Sbjct: 200 SASRQGYDVRSDVWSLGITLYELATGRFPYP------KWNSVFDQLTQVVKGDPPQLSNS 253 Query: 243 -----SPSFMQRLQPTVRNYVENRPRY 264 SPSF+ + + RP+Y Sbjct: 254 EEREFSPSFINFVNLCLTKDESKRPKY 280 >1AD5-A nrPDB Length = 438 Score = 64.7 bits (156), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 58/205 (28%), Positives = 95/205 (46%), Gaps = 27/205 (13%) Query: 28 RPIGSGAQGIV-CAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGL 86 + +G+G G V A Y+ T+ VA+K + +P A A E +MK + H ++ L Sbjct: 188 KKLGAGQFGEVWMATYNKHTK--VAVKTM-KPGSMSVEAFLA--EANVMKTLQHDKLVKL 242 Query: 87 LNAFTPQRNLEEFQDVYLVMELM-DANLCQVIQMDLDHD----RMSYLLYQMLCGIKHLH 141 T + +Y++ E M +L ++ D ++ Q+ G+ + Sbjct: 243 HAVVTKE-------PIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIE 295 Query: 142 SAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGYT 201 IHRDL+ +NI+V A KI DFGLAR G F + + APE I +T Sbjct: 296 QRNYIHRDLRAANILVSASLVCKIADFGLARV-GAKFPIK-------WTAPEAINFGSFT 347 Query: 202 ENVDIWSVGCIMGEMIR-GGVLFPG 225 D+WS G ++ E++ G + +PG Sbjct: 348 IKSDVWSFGILLMEIVTYGRIPYPG 372 >1JPA-A nrPDB Length = 312 Score = 64.3 bits (155), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 56/204 (27%), Positives = 93/204 (45%), Gaps = 20/204 (9%) Query: 30 IGSGAQGIVCAAYDTITQQN---VAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNII-- 84 IG+G G VC+ + + + VAIK L + + E +M +H N+I Sbjct: 41 IGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTE-KQRRDFLSEASIMGQFDHPNVIHL 99 Query: 85 -GLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGIKHLHSA 143 G++ TP + EF + + + N Q + L +L + G+K+L Sbjct: 100 EGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQL-----VGMLRGIAAGMKYLADM 154 Query: 144 GIIHRDLKPSNIVVKADCTLKILDFGLAR-----TAGTTF--MMTPYVVTRYYRAPEVIL 196 +HRDL NI+V ++ K+ DFGL+R T+ T+ + + R + APE I Sbjct: 155 NYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIR-WTAPEAIQ 213 Query: 197 GMGYTENVDIWSVGCIMGEMIRGG 220 +T D+WS G +M E++ G Sbjct: 214 YRKFTSASDVWSYGIVMWEVMSYG 237 >3PLS-A nrPDB Length = 298 Score = 64.3 bits (155), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 64/221 (28%), Positives = 98/221 (44%), Gaps = 26/221 (11%) Query: 28 RPIGSGAQGIVCAAYDTITQQN---VAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNII 84 R IG G G+V QN AIK LSR + + RE LM+ +NH N++ Sbjct: 27 RVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSR-ITEMQQVEAFLREGLLMRGLNHPNVL 85 Query: 85 GLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDH----DRMSYLLYQMLCGIKHL 140 L+ P L L+ + +L Q I+ + D +S+ L Q+ G+++L Sbjct: 86 ALIGIMLPPEGLPHV----LLPYMCHGDLLQFIRSPQRNPTVKDLISFGL-QVARGMEYL 140 Query: 141 HSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVT--RYYRAP------ 192 +HRDL N ++ T+K+ DFGLAR Y V R+ R P Sbjct: 141 AEQKFVHRDLAARNCMLDESFTVKVADFGLAR---DILDREYYSVQQHRHARLPVKWTAL 197 Query: 193 EVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWN 233 E + +T D+WS G ++ E++ G P HID ++ Sbjct: 198 ESLQTYRFTTKSDVWSFGVLLWELLTRGA--PPYRHIDPFD 236 >4EBW-A nrPDB Length = 304 Score = 64.3 bits (155), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 71/281 (25%), Positives = 124/281 (44%), Gaps = 26/281 (9%) Query: 3 TAQHQHYTVEVGDT--NFTIHSRYINL-RPIGSGAQGIVCAAYDTITQQNVAIKKLSRPF 59 T ++ ++ +G + ++ I I L R IG G G V ++ +N A+ + Sbjct: 16 TTENLYFQGAMGSSTRDYEIQRERIELGRCIGEGQFGDVHQGI-YMSPENPALAVAIKTC 74 Query: 60 QNVTH---AKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDA----N 112 +N T ++ +E M+ +H +I+ L+ T V+++MEL + Sbjct: 75 KNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITEN-------PVWIIMELCTLGELRS 127 Query: 113 LCQVIQMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLAR 172 QV + LD + YQ+ + +L S +HRD+ N++V ++ +K+ DFGL+R Sbjct: 128 FLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSR 187 Query: 173 TA--GTTFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVL-FPGTDHI 229 T + + + + APE I +T D+W G M E++ GV F G + Sbjct: 188 YMEDSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNN 247 Query: 230 DQWNKI--IEQLGTP--SPSFMQRLQPTVRNY-VENRPRYT 265 D +I E+L P P + L Y RPR+T Sbjct: 248 DVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFT 288 >4C59-A nrPDB Length = 340 Score = 64.3 bits (155), Expect = 9e-11, Method: Compositional matrix adjust. Identities = 62/231 (26%), Positives = 98/231 (42%), Gaps = 36/231 (15%) Query: 10 TVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAY 69 TVE+G+ + R + G V A D + + A+K+L N RA Sbjct: 21 TVELGELRLRVR------RVLAEGGFAFVYEAQDVGSGREYALKRL---LSNEEEKNRAI 71 Query: 70 -REFKLMK-LVNHKNIIGLLNAFTPQRNLEEF--QDVYLVMELMDANLCQVIQM-----D 120 +E MK L H NI+ +A + + + + L+ EL L + ++ Sbjct: 72 IQEVCFMKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGP 131 Query: 121 LDHDRMSYLLYQMLCGIKHLH--SAGIIHRDLKPSNIVVKADCTLKILDFGLART----- 173 L D + + YQ ++H+H IIHRDLK N+++ T+K+ DFG A T Sbjct: 132 LSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYP 191 Query: 174 ----AGTTFMMTPYVVTR----YYRAPEVI---LGMGYTENVDIWSVGCIM 213 + + +TR YR PE+I E DIW++GCI+ Sbjct: 192 DYSWSAQRRALVEEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCIL 242 >4CRS-A nrPDB Length = 341 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 55/191 (28%), Positives = 91/191 (47%), Gaps = 16/191 (8%) Query: 70 REFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVME-LMDANLCQVIQMDL-DHDRMS 127 R F+ + V H ++ L F + + V VME +L I D+ R Sbjct: 64 RIFETVNSVRHPFLVNLFACFQTKEH------VCFVMEYAAGGDLMMHIHTDVFSEPRAV 117 Query: 128 YLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTA-GTTFMMTPYVVT 186 + ++ G+++LH I++RDLK N+++ + +KI DFGL + G + + T Sbjct: 118 FYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGT 177 Query: 187 RYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQ-------L 239 + APEV+ YT VD W +G ++ EM+ G FPG D + ++ I+ L Sbjct: 178 PEFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFL 237 Query: 240 GTPSPSFMQRL 250 T + S M+RL Sbjct: 238 STEAISIMRRL 248 >5HVK-A nrPDB Length = 315 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 54/208 (25%), Positives = 91/208 (43%), Gaps = 29/208 (13%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNA 89 +G G G T + + +K+L R F T + +E K+M+ + H N++ + Sbjct: 22 LGKGCFGQAIKVTHRETGEVMVMKELIR-FDEETQ-RTFLKEVKVMRCLEHPNVLKFIGV 79 Query: 90 FTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHD-----RMSYLLYQMLCGIKHLHSAG 144 + L + E + + I +D R+S+ + G+ +LHS Sbjct: 80 LYKDKRLN------FITEYIKGGTLRGIIKSMDSQYPWSQRVSFA-KDIASGMAYLHSMN 132 Query: 145 IIHRDLKPSNIVVKADCTLKILDFGLAR--------TAGTTFMMTP-------YVVTRYY 189 IIHR+L N +V+ + + + DFGLAR G + P V Y+ Sbjct: 133 IIHRNLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYW 192 Query: 190 RAPEVILGMGYTENVDIWSVGCIMGEMI 217 APE+I G Y E VD++S G ++ E+I Sbjct: 193 MAPEMINGRSYDEKVDVFSFGIVLCEII 220 >4P5Q-A nrPDB Length = 361 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 60/234 (25%), Positives = 98/234 (41%), Gaps = 32/234 (13%) Query: 2 TTAQHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQ---NVAIKKLSRP 58 +T + E+ TN +I + +G+G G VC+ + + +VAIK L Sbjct: 19 STQTVHEFAKELDATNISID------KVVGAGEFGEVCSGRLKLPSKKEISVAIKTL--- 69 Query: 59 FQNVTHAKRAYREF----KLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLC 114 V + ++ R+F +M +H NII L T + V +V E M+ Sbjct: 70 --KVGYTEKQRRDFLGEASIMGQFDHPNIIRLEGVVTKSK------PVMIVTEYMENGSL 121 Query: 115 QVIQMDLDHDRMSYLLYQMLCGI----KHLHSAGIIHRDLKPSNIVVKADCTLKILDFGL 170 D L ML GI K+L G +HRDL NI++ ++ K+ DFGL Sbjct: 122 DSFLRKHDAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGL 181 Query: 171 ART----AGTTFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGG 220 +R + + + +PE I +T D+WS G ++ E++ G Sbjct: 182 SRVLEDDPEAAYTTRGGKIPIRWTSPEAIAYRKFTSASDVWSYGIVLWEVMSYG 235 >4XEY-B nrPDB Length = 408 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 53/219 (24%), Positives = 102/219 (46%), Gaps = 22/219 (10%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNA 89 +G G G V VA+K L ++ + +E +MK + H N++ LL Sbjct: 133 LGGGQYGEVYEGVWKKYSLTVAVKTLK---EDTMEVEEFLKEAAVMKEIKHPNLVQLLGV 189 Query: 90 FTPQRNLEEFQDVYLVMELMD-ANLCQVIQ----MDLDHDRMSYLLYQMLCGIKHLHSAG 144 T + Y++ E M NL ++ +++ + Y+ Q+ +++L Sbjct: 190 CTRE------PPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKN 243 Query: 145 IIHRDLKPSNIVVKADCTLKILDFGLAR-TAGTTFMMTPYVVTRY---YRAPEVILGMGY 200 IHRDL N +V + +K+ DFGL+R G T+ T + ++ + APE + + Sbjct: 244 FIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTY--TAHAGAKFPIKWTAPESLAYNKF 301 Query: 201 TENVDIWSVGCIMGEMIRGGVL-FPGTDHIDQWNKIIEQ 238 + D+W+ G ++ E+ G+ +PG D + Q +++E+ Sbjct: 302 SIKSDVWAFGVLLWEIATYGMSPYPGID-LSQVYELLEK 339 >5VD3-A nrPDB Length = 311 Score = 62.8 bits (151), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 52/196 (26%), Positives = 85/196 (43%), Gaps = 9/196 (4%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNI 83 + L +G G+ G V + A+K+ PF+ R KL ++ +H+ + Sbjct: 59 FQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRAR-----KLAEVGSHEKV 113 Query: 84 IGLLNAFTPQRNLEEFQDVYLVMELMDANL---CQVIQMDLDHDRMSYLLYQMLCGIKHL 140 ++ EE +YL EL +L C+ L ++ L L + HL Sbjct: 114 GQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHL 173 Query: 141 HSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGY 200 HS G++H D+KP+NI + K+ DFGL GT Y APE++ G Y Sbjct: 174 HSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQG-SY 232 Query: 201 TENVDIWSVGCIMGEM 216 D++S+G + E+ Sbjct: 233 GTAADVFSLGLTILEV 248 >6NPU-A nrPDB Length = 298 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 51/208 (24%), Positives = 95/208 (45%), Gaps = 21/208 (10%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNA 89 +G G G V VA+K L ++ + +E +MK + H N++ LL Sbjct: 34 LGGGQYGEVYEGVWKKYSLTVAVKTLK---EDTMEVEEFLKEAAVMKEIKHPNLVQLLGV 90 Query: 90 FTPQRNLEEFQDVYLVMELMD-ANLCQVIQ----MDLDHDRMSYLLYQMLCGIKHLHSAG 144 T + Y++ E M NL ++ +++ + Y+ Q+ +++L Sbjct: 91 CTREPPF------YIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKN 144 Query: 145 IIHRDLKPSNIVVKADCTLKILDFGLAR-TAGTTFMMTPYVVTRY---YRAPEVILGMGY 200 IHRDL N +V + +K+ DFGL+R G T+ T + ++ + APE + + Sbjct: 145 FIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTY--TAHAGAKFPIKWTAPESLAYNKF 202 Query: 201 TENVDIWSVGCIMGEMIRGGVL-FPGTD 227 + D+W+ G ++ E+ G+ +PG D Sbjct: 203 SIKSDVWAFGVLLWEIATYGMSPYPGID 230 >2PL0-A nrPDB Length = 289 Score = 62.0 bits (149), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 57/211 (27%), Positives = 94/211 (44%), Gaps = 33/211 (15%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNA 89 +G+G G V Y VA+K L Q E LMK + H+ ++ L Sbjct: 31 LGAGQFGEVWMGYYN-GHTKVAVKSLK---QGSMSPDAFLAEANLMKQLQHQRLVRLYAV 86 Query: 90 FTPQRNLEEFQDVYLVMELMD-ANLCQVIQ----MDLDHDRMSYLLYQMLCGIKHLHSAG 144 T + +Y++ E M+ +L ++ + L +++ + Q+ G+ + Sbjct: 87 VTQE-------PIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERN 139 Query: 145 IIHRDLKPSNIVVKADCTLKILDFGLAR-------TA--GTTFMMTPYVVTRYYRAPEVI 195 IHRDL+ +NI+V + KI DFGLAR TA G F + + APE I Sbjct: 140 YIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIK-------WTAPEAI 192 Query: 196 LGMGYTENVDIWSVGCIMGEMI-RGGVLFPG 225 +T D+WS G ++ E++ G + +PG Sbjct: 193 NYGTFTIKSDVWSFGILLTEIVTHGRIPYPG 223 >2RIO-A nrPDB Length = 434 Score = 62.0 bits (149), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 64/227 (28%), Positives = 106/227 (46%), Gaps = 49/227 (21%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLM-KLVNHKNIIGLLN 88 +G G+ G V + + VA+K++ F ++ A E KL+ + +H N+I Sbjct: 23 LGYGSSGTVVFQ-GSFQGRPVAVKRMLIDFCDI-----ALMEIKLLTESDDHPNVIRYYC 76 Query: 89 AFTPQRNLEEFQDVYLVMELMDANLCQVIQ----------MDLDHDRMSYLLYQMLCGIK 138 + T R L Y+ +EL + NL +++ + +++ +S LL Q+ G+ Sbjct: 77 SETTDRFL------YIALELCNLNLQDLVESKNVSDENLKLQKEYNPIS-LLRQIASGVA 129 Query: 139 HLHSAGIIHRDLKPSNIVVKADC-----------TLKIL--DFGLART--AGTTFMMTPY 183 HLHS IIHRDLKP NI+V L+IL DFGL + +G + T Sbjct: 130 HLHSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFRTNL 189 Query: 184 ---VVTRYYRAPEVI-------LGMGYTENVDIWSVGCIMGEMIRGG 220 T +RAPE++ T ++DI+S+GC+ ++ G Sbjct: 190 NNPSGTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKG 236 >3CJF-A nrPDB Length = 309 Score = 61.6 bits (148), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 68/224 (30%), Positives = 105/224 (46%), Gaps = 31/224 (13%) Query: 28 RPIGSGAQGIVCAAY-----DTITQQNVAIKKLSRPFQNVTHAK-RAY-REFK-LMKLVN 79 +P+G GA G V A T T + VA+K L + TH++ RA E K L+ + + Sbjct: 33 KPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLK---EGATHSEHRALMSELKILIHIGH 89 Query: 80 HKNIIGLLNAFT----PQRNLEEFQDVYLVMELMDANLCQVIQ-MDLDHDRMS--YLL-- 130 H N++ LL A T P + EF + + + + + DL D ++ +L+ Sbjct: 90 HLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKDLYKDFLTLEHLICY 149 Query: 131 -YQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYV----- 184 +Q+ G++ L S IHRDL NI++ +KI DFGLAR + YV Sbjct: 150 SFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLAR---DIYKDPDYVRKGDA 206 Query: 185 -VTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGT 226 + + APE I YT D+WS G ++ E+ G +PG Sbjct: 207 RLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGV 250 >4CSV-A nrPDB Length = 275 Score = 61.6 bits (148), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 59/227 (25%), Positives = 98/227 (43%), Gaps = 35/227 (15%) Query: 28 RPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLL 87 R +GSG G V VA+K L + + +E ++MK + H N++ L Sbjct: 17 RKLGSGQFGEVYEGKWRNYNIEVAVKTLK---EGTMSVEEFLQEAQIMKKLKHPNLVQLY 73 Query: 88 NAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQMDLDHDRMSYLLY----QMLCGIKHLHS 142 T + +Y++ E M +L ++ H + L Q+ G+ +L S Sbjct: 74 GVCTKE------PPIYIITEYMSHGSLLDYLRDCEGHTVNAQALLDMAAQVASGMAYLES 127 Query: 143 AGIIHRDLKPSNIVVKADCTLKILDFGLART---------AGTTFMMTPYVVTRYYRAPE 193 IHRDL N +V + +K+ DFGLAR AG F + + APE Sbjct: 128 QNFIHRDLAARNCLVGENNVVKVADFGLARLINEDEYTARAGAKFPIK-------WTAPE 180 Query: 194 VILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQWNKIIEQL 239 I ++ D+W+ G ++ E+ G V +PG +++IEQ+ Sbjct: 181 AISYNRFSIKSDVWAFGILLWEIFTYGQVPYPGMSG----SEVIEQV 223 >5UUU-A nrPDB Length = 547 Score = 61.6 bits (148), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 57/216 (26%), Positives = 105/216 (48%), Gaps = 31/216 (14%) Query: 17 NFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKR-AYREFKLM 75 +F++H R IG G G V T + A+K L + + + A E ++ Sbjct: 199 DFSVH------RIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIML 252 Query: 76 KLVNHKN---IIGLLNAF-TPQRNLEEFQDVYLVMELMDA-----NLCQVIQMDLDHDRM 126 LV+ + I+ + AF TP + + +++LM+ +L Q M Sbjct: 253 SLVSTGDCPFIVCMSYAFHTPDK-------LSFILDLMNGGDLHYHLSQ--HGVFSEADM 303 Query: 127 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPY--V 184 + +++ G++H+H+ +++RDLKP+NI++ ++I D GLA P+ V Sbjct: 304 RFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKK---KPHASV 360 Query: 185 VTRYYRAPEVI-LGMGYTENVDIWSVGCIMGEMIRG 219 T Y APEV+ G+ Y + D +S+GC++ +++RG Sbjct: 361 GTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRG 396 >2XYN-A nrPDB Length = 292 Score = 61.6 bits (148), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 61/264 (23%), Positives = 118/264 (44%), Gaps = 30/264 (11%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNA 89 +G G G V VA+K L ++ + +E +MK + H N++ LL Sbjct: 40 LGGGQYGEVYVGVWKKYSLTVAVKTLK---EDTMEVEEFLKEAAVMKEIKHPNLVQLLGV 96 Query: 90 FTPQRNLEEFQDVYLVMELMD-ANLCQVIQMDLDHDRMS-----YLLYQMLCGIKHLHSA 143 T + Y+V E M NL ++ + + + ++ Y+ Q+ +++L Sbjct: 97 CTLEPPF------YIVTEYMPYGNLLDYLR-ECNREEVTAVVLLYMATQISSAMEYLEKK 149 Query: 144 GIIHRDLKPSNIVVKADCTLKILDFGLAR-TAGTTFMMTPYVVTRY---YRAPEVILGMG 199 IHRDL N +V + +K+ DFGL+R G T+ T + ++ + APE + Sbjct: 150 NFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTY--TAHAGAKFPIKWTAPESLAYNT 207 Query: 200 YTENVDIWSVGCIMGEMIRGGVL-FPGTDHIDQWNKI-----IEQLGTPSPSFMQRLQPT 253 ++ D+W+ G ++ E+ G+ +PG D ++ + +EQ P + ++ Sbjct: 208 FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRAC 267 Query: 254 VRNYVENRPRY--TGYSFDRLFPD 275 + +RP + T +F+ +F D Sbjct: 268 WKWSPADRPSFAETHQAFETMFHD 291 >6BXI-A nrPDB Length = 333 Score = 61.6 bits (148), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 62/239 (25%), Positives = 99/239 (41%), Gaps = 52/239 (21%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRP----FQNVTHAKRAYREFKLMKLVN 79 + +L+ IG GA G V T A+K L + + V H RA R+ ++ + Sbjct: 8 FESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHI-RAERD--ILVEAD 64 Query: 80 HKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLD---HDRMSYLLYQMLCG 136 ++ + +F + NL YL+ME + + M D + + + + + Sbjct: 65 SLWVVKMFYSFQDKLNL------YLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLA 118 Query: 137 IKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLA-------RT-----------AGTTF 178 I +H G IHRD+KP N+++ + +K+ DFGL RT + TF Sbjct: 119 IDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTF 178 Query: 179 ------------------MMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRG 219 + V T Y APEV + GY + D WS+G IM EM+ G Sbjct: 179 QNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIG 237 >5L6P-A nrPDB Length = 298 Score = 61.6 bits (148), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 61/210 (29%), Positives = 90/210 (42%), Gaps = 32/210 (15%) Query: 30 IGSGAQGIVCAAYDTITQQN-----VAIKKLSRPFQNVTHAKRAYREF----KLMKLVNH 80 IG+G G VC + Q VAIK L V + +R R+F +M +H Sbjct: 27 IGAGEFGEVCRG--RLKQPGRREVFVAIKTL-----KVGYTERQRRDFLSEASIMGQFDH 79 Query: 81 KNIIGLLNAFTPQRN---LEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGI 137 NII L T R L EF + + + N Q + L +L + G+ Sbjct: 80 PNIIRLEGVVTKSRPVMILTEFMENCALDSFLRLNDGQFTVIQLVG-----MLRGIAAGM 134 Query: 138 KHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLAR-------TAGTTFMMTPYVVTRYYR 190 K+L +HRDL NI+V ++ K+ DFGL+R T + + R+ Sbjct: 135 KYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWT- 193 Query: 191 APEVILGMGYTENVDIWSVGCIMGEMIRGG 220 APE I +T D+WS G +M E++ G Sbjct: 194 APEAIAYRKFTSASDVWSYGIVMWEVMSYG 223 >4E93-A nrPDB Length = 377 Score = 61.2 bits (147), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 63/227 (27%), Positives = 102/227 (44%), Gaps = 19/227 (8%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNA 89 IG G G V + VA+K AK +E +++K +H NI+ L+ Sbjct: 122 IGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAK-FLQEARILKQYSHPNIVRLIGV 180 Query: 90 FTPQRNLEEFQDVYLVMELMDA-NLCQVIQMDLDHDRMSYLLYQML----CGIKHLHSAG 144 T + Q +Y+VMEL+ + ++ + R+ LL QM+ G+++L S Sbjct: 181 CTQK------QPIYIVMELVQGGDFLTFLRTEGARLRVKTLL-QMVGDAAAGMEYLESKC 233 Query: 145 IIHRDLKPSNIVVKADCTLKILDFGLAR-TAGTTFMMTPYV--VTRYYRAPEVILGMGYT 201 IHRDL N +V LKI DFG++R A + + + V + APE + Y+ Sbjct: 234 CIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYS 293 Query: 202 ENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQWNKIIEQLG-TPSPSF 246 D+WS G ++ E G +P + Q + +E+ G P P Sbjct: 294 SESDVWSFGILLWETFSLGASPYPNLSN-QQTREFVEKGGRLPCPEL 339 >2W1I-A nrPDB Length = 326 Score = 61.2 bits (147), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 55/205 (26%), Positives = 96/205 (46%), Gaps = 22/205 (10%) Query: 27 LRPIGSGAQGIV-CAAYDTI---TQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKN 82 L+ +G G G V YD + T + VA+KKL + H + RE +++K + H N Sbjct: 46 LQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEE--HLRDFEREIEILKSLQHDN 103 Query: 83 IIGLLNAF--TPQRNLEEFQDVYLVMELMD----ANLCQVIQMDLDHDRMSYLLYQMLCG 136 I+ +RNL+ L+ME + + Q + +DH ++ Q+ G Sbjct: 104 IVKYKGVCYSAGRRNLK------LIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKG 157 Query: 137 IKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTT----FMMTPYVVTRYYRAP 192 +++L + IHRDL NI+V+ + +KI DFGL + + P ++ AP Sbjct: 158 MEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAP 217 Query: 193 EVILGMGYTENVDIWSVGCIMGEMI 217 E + ++ D+WS G ++ E+ Sbjct: 218 ESLTESKFSVASDVWSFGVVLYELF 242 >1FVR-A nrPDB Length = 327 Score = 61.2 bits (147), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 61/222 (27%), Positives = 91/222 (40%), Gaps = 16/222 (7%) Query: 30 IGSGAQGIVCAA--YDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLL 87 IG G G V A + + AIK++ H A L KL +H NII LL Sbjct: 33 IGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLL 92 Query: 88 NA------------FTPQRNLEEFQDVYLVMELMDA-NLCQVIQMDLDHDRMSYLLYQML 134 A + P NL +F V+E A + L ++ + + Sbjct: 93 GACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVA 152 Query: 135 CGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEV 194 G+ +L IHRDL NI+V + KI DFGL+R T + + A E Sbjct: 153 RGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIES 212 Query: 195 ILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQWNKI 235 + YT N D+WS G ++ E++ GG + G + + K+ Sbjct: 213 LNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKL 254 >3PVW-A nrPDB Length = 695 Score = 61.2 bits (147), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 57/216 (26%), Positives = 105/216 (48%), Gaps = 31/216 (14%) Query: 17 NFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKR-AYREFKLM 75 +F++H R IG G G V T + A+K L + + + A E ++ Sbjct: 190 DFSVH------RIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIML 243 Query: 76 KLVNHKN---IIGLLNAF-TPQRNLEEFQDVYLVMELMDA-----NLCQVIQMDLDHDRM 126 LV+ + I+ + AF TP + + +++LM+ +L Q M Sbjct: 244 SLVSTGDCPFIVCMSYAFHTPDK-------LSFILDLMNGGDLHYHLSQ--HGVFSEADM 294 Query: 127 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPY--V 184 + +++ G++H+H+ +++RDLKP+NI++ ++I D GLA P+ V Sbjct: 295 RFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKK---KPHASV 351 Query: 185 VTRYYRAPEVI-LGMGYTENVDIWSVGCIMGEMIRG 219 T Y APEV+ G+ Y + D +S+GC++ +++RG Sbjct: 352 GTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRG 387 >2FO0-A nrPDB Length = 495 Score = 61.2 bits (147), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 50/208 (24%), Positives = 95/208 (45%), Gaps = 21/208 (10%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNA 89 +G G G V VA+K L ++ + +E +MK + H N++ LL Sbjct: 225 LGGGQYGEVYEGVWKKYSLTVAVKTLK---EDTMEVEEFLKEAAVMKEIKHPNLVQLLGV 281 Query: 90 FTPQRNLEEFQDVYLVMELMD-ANLCQVIQ----MDLDHDRMSYLLYQMLCGIKHLHSAG 144 T + Y++ E M NL ++ +++ + Y+ Q+ +++L Sbjct: 282 CTRE------PPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKN 335 Query: 145 IIHRDLKPSNIVVKADCTLKILDFGLAR-TAGTTFMMTPYVVTRY---YRAPEVILGMGY 200 IHR+L N +V + +K+ DFGL+R G T+ T + ++ + APE + + Sbjct: 336 FIHRNLAARNCLVGENHLVKVADFGLSRLMTGDTY--TAHAGAKFPIKWTAPESLAYNKF 393 Query: 201 TENVDIWSVGCIMGEMIRGGVL-FPGTD 227 + D+W+ G ++ E+ G+ +PG D Sbjct: 394 SIKSDVWAFGVLLWEIATYGMSPYPGID 421 >5HI2-A nrPDB Length = 283 Score = 60.8 bits (146), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 68/274 (24%), Positives = 116/274 (42%), Gaps = 64/274 (23%) Query: 12 EVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLS----RPFQNVTHAKR 67 E+ D T+ R IGSG+ G V Y +VA+K L+ + F+N Sbjct: 16 EIPDGQITVGQR------IGSGSFGTV---YKGKWHGDVAVKMLTPQQLQAFKN------ 60 Query: 68 AYREFKLMKLVNHKNIIGLLNAFT-PQRNLEEFQDVYLVMELMDANLC----QVIQMDLD 122 E +++ H NI+ + T PQ + +V + + + + + Sbjct: 61 ---EVGVLRKTRHVNILLFMGYSTKPQ--------LAIVTQWCEGSSLYHHLHASETKFE 109 Query: 123 HDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLA----------- 171 ++ + Q G+ +LH+ IIHRDLK +NI + D T+KI DFGLA Sbjct: 110 MKKLIDIARQTARGMDYLHAKSIIHRDLKSNNIFLHEDNTVKIGDFGLATVKSRWSGSHQ 169 Query: 172 --RTAGTTFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHI 229 + +G+ M P V+ P Y+ D+++ G ++ E++ G + + ++ Sbjct: 170 FEQLSGSILWMAPEVIRMQDSNP-------YSFQSDVYAFGIVLYELMTGQLPYSNINNR 222 Query: 230 DQWNKIIEQLGTPSPSFMQRLQPTVRNYVENRPR 263 DQ IIE +G S L P + N P+ Sbjct: 223 DQ---IIEMVGRGS------LSPDLSKVRSNCPK 247 >3IO7-A nrPDB Length = 313 Score = 60.8 bits (146), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 55/205 (26%), Positives = 96/205 (46%), Gaps = 22/205 (10%) Query: 27 LRPIGSGAQGIV-CAAYDTI---TQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKN 82 L+ +G G G V YD + T + VA+KKL + H + RE +++K + H N Sbjct: 33 LQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEE--HLRDFEREIEILKSLQHDN 90 Query: 83 IIGLLNAF--TPQRNLEEFQDVYLVMELMD----ANLCQVIQMDLDHDRMSYLLYQMLCG 136 I+ +RNL+ L+ME + + Q + +DH ++ Q+ G Sbjct: 91 IVKYKGVCYSAGRRNLK------LIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKG 144 Query: 137 IKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTT----FMMTPYVVTRYYRAP 192 +++L + IHRDL NI+V+ + +KI DFGL + + P ++ AP Sbjct: 145 MEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAP 204 Query: 193 EVILGMGYTENVDIWSVGCIMGEMI 217 E + ++ D+WS G ++ E+ Sbjct: 205 ESLTESKFSVASDVWSFGVVLYELF 229 >5HIE-A nrPDB Length = 302 Score = 60.8 bits (146), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 61/242 (25%), Positives = 106/242 (43%), Gaps = 55/242 (22%) Query: 12 EVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLS----RPFQNVTHAKR 67 E+ D T+ R IGSG+ G V Y +VA+K L+ + F+N Sbjct: 32 EIPDGQITVGQR------IGSGSFGTV---YKGKWHGDVAVKMLTPQQLQAFKN------ 76 Query: 68 AYREFKLMKLVNHKNIIGLLNAFT-PQRNLE----EFQDVYLVMELMDANLCQVIQMDLD 122 E +++ H NI+ + T PQ + E +Y + +++ + +D+ Sbjct: 77 ---EVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIA 133 Query: 123 HDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLA----------- 171 Q G+ +LH+ IIHRDLK +NI + D T+KI DFGLA Sbjct: 134 R--------QTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQ 185 Query: 172 --RTAGTTFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHI 229 + +G+ M P V+ + P Y+ D+++ G ++ E++ G + + ++ Sbjct: 186 FEQLSGSILWMAPEVIRMQDKNP-------YSFQSDVYAFGIVLYELMTGQLPYSNINNR 238 Query: 230 DQ 231 DQ Sbjct: 239 DQ 240 >4HVI-A nrPDB Length = 314 Score = 60.8 bits (146), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 61/215 (28%), Positives = 103/215 (47%), Gaps = 32/215 (14%) Query: 21 HSRYINLRPIGSGAQGIV-CAAYDTI---TQQNVAIKKL--SRPFQNVTHAKRAYREFKL 74 H +YI+ +G G G V YD + T VA+K+L S P Q + RE ++ Sbjct: 11 HLKYISQ--LGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQ----RDFQREIQI 64 Query: 75 MKLVNHKNIIGLLN-AFTPQRNLEEFQDVYLVMELMDA----NLCQVIQMDLDHDRMSYL 129 +K ++ I+ ++ P R Q + LVME + + + Q + LD R+ Sbjct: 65 LKALHSDFIVKYRGVSYGPGR-----QSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLY 119 Query: 130 LYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTR-- 187 Q+ G+++L S +HRDL NI+V+++ +KI DFGLA+ + Y V R Sbjct: 120 SSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLP---LDKDYYVVREP 176 Query: 188 -----YYRAPEVILGMGYTENVDIWSVGCIMGEMI 217 ++ APE + ++ D+WS G ++ E+ Sbjct: 177 GQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELF 211 >4NEU-A nrPDB Length = 333 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 43/153 (28%), Positives = 74/153 (48%), Gaps = 10/153 (6%) Query: 22 SRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHK 81 S ++ + SG G V + TQ + +K + + + H + E K+M + H Sbjct: 24 SDFLESAELDSGGFGKVSLCFHR-TQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHS 82 Query: 82 NIIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQMDLDH--DRMSYLLYQMLCGIK 138 ++ LL + LVME M+ NL V++ ++ ++ +++ G+ Sbjct: 83 RVVKLLGVIIEEGKYS------LVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMC 136 Query: 139 HLHSAGIIHRDLKPSNIVVKADCTLKILDFGLA 171 +LH G+IH+DLKP NI+V D +KI D GLA Sbjct: 137 YLHGKGVIHKDLKPENILVDNDFHIKIADLGLA 169 >5O2C-A nrPDB Length = 380 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 64/237 (27%), Positives = 105/237 (44%), Gaps = 11/237 (4%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNA 89 +G GA V DT T VA +L +R E +++K + H NI+ ++ Sbjct: 33 LGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDS 92 Query: 90 FTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYL---LYQMLCGIKHLHSAG-- 144 + + L+ + + LV ELM + + + L Q+L G++ LH+ Sbjct: 93 W--ESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPP 150 Query: 145 IIHRDLKPSNIVVKADC-TLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGYTEN 203 IIHRDLK NI + ++KI D GLA T+F + + T + APE + Y E+ Sbjct: 151 IIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKS-VIGTPEFMAPE-MYEEHYDES 208 Query: 204 VDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVEN 260 VD+++ G M EM + + Q + + G SF + P V+ +E Sbjct: 209 VDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTS-GIKPASFNKVTDPEVKEIIEG 264 >4TPT-A nrPDB Length = 303 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 63/271 (23%), Positives = 107/271 (39%), Gaps = 47/271 (17%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNA 89 +G G G T + + +K+L R + K E K+M+ ++H N++ + Sbjct: 8 LGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQ--KTFLTEVKVMRSLDHPNVLKFIGV 65 Query: 90 FTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDH---DRMSYLLYQMLCGIKHLHSAGII 146 + L L+ E ++ + +D + + G+ +LHS II Sbjct: 66 LYKDKKLN------LLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMAYLHSMCII 119 Query: 147 HRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTP-------------------YVVTR 187 HRDL N ++K D T+ + DFGL+R P Y V Sbjct: 120 HRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVG 179 Query: 188 --YYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQ-----------WNK 234 Y+ APE++ G Y E VDI+S G ++ E+I G ++ D + + W K Sbjct: 180 NPYWMAPEMLNGKSYDETVDIFSFGIVLCEII--GQVYADPDCLPRTLDFGLNVKLFWEK 237 Query: 235 IIEQLGTPSPSFMQRLQPTVRNYVENRPRYT 265 + P+F R E+RP ++ Sbjct: 238 FVPT--DCPPAFFPLAAICCRLEPESRPAFS 266 >2HK5-A nrPDB Length = 270 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 58/217 (26%), Positives = 96/217 (44%), Gaps = 35/217 (16%) Query: 28 RPIGSGAQGIV-CAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGL 86 + +G+G G V A Y+ T+ VA+K + +P A A E +MK + H ++ L Sbjct: 21 KKLGAGQFGEVWMATYNKHTK--VAVKTM-KPGSMSVEAFLA--EANVMKTLQHDKLVKL 75 Query: 87 LNAFTPQRNLEEFQDVYLVMELM-DANLCQVIQMDLDHD----RMSYLLYQMLCGIKHLH 141 T + +Y++ E M +L ++ D ++ Q+ G+ + Sbjct: 76 HAVVTKE-------PIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIE 128 Query: 142 SAGIIHRDLKPSNIVVKADCTLKILDFGLART---------AGTTFMMTPYVVTRYYRAP 192 IHRDL+ +NI+V A KI DFGLAR G F + + AP Sbjct: 129 QRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIK-------WTAP 181 Query: 193 EVILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGTDH 228 E I +T D+WS G ++ E++ G + +PG + Sbjct: 182 EAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSN 218 >5TUR-A nrPDB Length = 404 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 55/206 (26%), Positives = 95/206 (46%), Gaps = 19/206 (9%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRP----FQNVTHAKRAYREFKLMKLVNH--KNI 83 +GSG G V + VAIK + + + + + R E L+K V+ + Sbjct: 135 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGV 194 Query: 84 IGLLNAFTPQRNLEEFQDVYLVMELMDA--NLCQVI--QMDLDHDRMSYLLYQMLCGIKH 139 I LL+ F E L++E + +L I + L + +Q+L ++H Sbjct: 195 IRLLDWF------ERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRH 248 Query: 140 LHSAGIIHRDLKPSNIVVKAD-CTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGM 198 H+ G++HRD+K NI++ + LK++DFG T + T + TR Y PE I Sbjct: 249 CHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDT-VYTDFDGTRVYSPPEWIRYH 307 Query: 199 GY-TENVDIWSVGCIMGEMIRGGVLF 223 Y + +WS+G ++ +M+ G + F Sbjct: 308 RYHGRSAAVWSLGILLYDMVCGDIPF 333 >5MJB-A nrPDB Length = 305 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 50/180 (27%), Positives = 80/180 (44%), Gaps = 15/180 (8%) Query: 50 VAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRN---LEEFQDVYLVM 106 VAIK L + + E +M +H+NII L T R + EF + + Sbjct: 57 VAIKTLKAGYSE-KQRRDFLSEASIMGQFDHRNIIRLEGVVTKSRPVMIITEFMENCALD 115 Query: 107 ELMDANLCQVIQMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKIL 166 + N Q + L +L + G+K+L +HRDL NI+V ++ K+ Sbjct: 116 SFLRQNDGQFTVIQLVG-----MLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVS 170 Query: 167 DFGLAR-----TAGTTFMMT-PYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGG 220 DFGL+R T+ T+ + + + APE I +T D+WS G +M E++ G Sbjct: 171 DFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSFG 230 >4RC3-A nrPDB Length = 289 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 54/209 (25%), Positives = 93/209 (44%), Gaps = 25/209 (11%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRP----FQNVTHAKRAYREFKLMKLVNH--KNI 83 +GSG G V + VAIK + + + + + R E L+K V+ + Sbjct: 20 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGV 79 Query: 84 IGLLNAFTPQRNL-------EEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCG 136 I LL+ F + E QD++ + A L + +Q+L Sbjct: 80 IRLLDWFERPDSFVLILERPEPVQDLFDFITERGA---------LQEELARSFFWQVLEA 130 Query: 137 IKHLHSAGIIHRDLKPSNIVVKAD-CTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVI 195 ++H H+ G++HRD+K NI++ + LK++DFG T + T + TR Y PE I Sbjct: 131 VRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDT-VYTDFDGTRVYSPPEWI 189 Query: 196 LGMGY-TENVDIWSVGCIMGEMIRGGVLF 223 Y + +WS+G ++ +M+ G + F Sbjct: 190 RYHRYHGRSAAVWSLGILLYDMVCGDIPF 218 >3A4O-X nrPDB Length = 286 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 56/220 (25%), Positives = 97/220 (44%), Gaps = 34/220 (15%) Query: 27 LRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAY-REFKLMKLVNHKNIIG 85 ++ +G+G G V Y VA+K L + T + +A+ E LMK + H ++ Sbjct: 18 VKRLGAGQFGEVWMGYYN-NSTKVAVKTL----KPGTMSVQAFLEEANLMKTLQHDKLVR 72 Query: 86 LLNAFTPQRNLEEFQDVYLVMELM-DANLCQVIQMDLDHD----RMSYLLYQMLCGIKHL 140 L T + + +Y++ E M +L ++ D ++ Q+ G+ ++ Sbjct: 73 LYAVVTRE------EPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYI 126 Query: 141 HSAGIIHRDLKPSNIVVKADCTLKILDFGLART---------AGTTFMMTPYVVTRYYRA 191 IHRDL+ +N++V KI DFGLAR G F + + A Sbjct: 127 ERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIK-------WTA 179 Query: 192 PEVILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGTDHID 230 PE I +T D+WS G ++ E++ G + +PG + D Sbjct: 180 PEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNAD 219 >2BUJ-A nrPDB Length = 317 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 47/174 (27%), Positives = 81/174 (46%), Gaps = 22/174 (12%) Query: 66 KRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQMDLD-- 122 + A RE + +L NH NI+ L+ +R + + +L++ L I+ D Sbjct: 71 EEAQREADMHRLFNHPNILRLVAYCLRERGAK--HEAWLLLPFFKRGTLWNEIERLKDKG 128 Query: 123 ----HDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGL-------- 170 D++ +LL + G++ +H+ G HRDLKP+NI++ + ++D G Sbjct: 129 NFLTEDQILWLLLGICRGLEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHV 188 Query: 171 --ARTAGTTFMMTPYVVTRYYRAPEVILGMGYT---ENVDIWSVGCIMGEMIRG 219 +R A T T YRAPE+ + E D+WS+GC++ M+ G Sbjct: 189 EGSRQALTLQDWAAQRCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFG 242 >5X02-A nrPDB Length = 347 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 65/248 (26%), Positives = 106/248 (42%), Gaps = 47/248 (18%) Query: 28 RPIGSGAQG-IVCAAYDTITQQNVAIK---KLSRPFQNVTHAKRAYREFKLM-KLVNHKN 82 + +GSGA G ++ A I++ V+I+ K+ + + + + E K+M +L +H+N Sbjct: 54 KVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHEN 113 Query: 83 IIGLLNAFTPQRNLEEFQDVYLVMELMD----ANLCQVIQMDLDHDRMSY---------- 128 I+ LL A T +YL+ E N + + D + Y Sbjct: 114 IVNLLGACTLS------GPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRLEEEE 167 Query: 129 ------------LLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGT 176 YQ+ G++ L +HRDL N++V +KI DFGLAR + Sbjct: 168 DLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMS 227 Query: 177 TFMMTPYVVTRYYR------APEVILGMGYTENVDIWSVGCIMGEMIRGGV-LFPGTDHI 229 + YVV R APE + YT D+WS G ++ E+ GV +PG Sbjct: 228 D---SNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVD 284 Query: 230 DQWNKIIE 237 + K+I+ Sbjct: 285 ANFYKLIQ 292 >4X7Q-B nrPDB Length = 312 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 60/212 (28%), Positives = 91/212 (42%), Gaps = 29/212 (13%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSR-------PFQN-VTHAKRAYREFKLMKLVNHK 81 +G G G V A + + VAIK + R P + VT +K+ H Sbjct: 39 LGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHP 98 Query: 82 NIIGLLNAFTPQRNLEEFQDVYLVME--LMDANLCQVI--QMDLDHDRMSYLLYQMLCGI 137 +I LL+ F Q LV+E L +L I + L Q++ I Sbjct: 99 GVIRLLDWFETQEGF------MLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAI 152 Query: 138 KHLHSAGIIHRDLKPSNIVV--KADCTLKILDFGLARTAGTTFMMTPYV---VTRYYRAP 192 +H HS G++HRD+K NI++ + C K++DFG +G PY TR Y P Sbjct: 153 QHCHSRGVVHRDIKDENILIDLRRGCA-KLIDFG----SGALLHDEPYTDFDGTRVYSPP 207 Query: 193 EVILGMGY-TENVDIWSVGCIMGEMIRGGVLF 223 E I Y +WS+G ++ +M+ G + F Sbjct: 208 EWISRHQYHALPATVWSLGILLYDMVCGDIPF 239 >4XI2-A nrPDB Length = 446 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 53/210 (25%), Positives = 97/210 (46%), Gaps = 32/210 (15%) Query: 27 LRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGL 86 L+ +G+G G+V Q +VAIK + + E K+M ++H+ ++ L Sbjct: 192 LKELGTGQFGVVKYG-KWRGQYDVAIKMIR---EGSMSEDEFIEEAKVMMNLSHEKLVQL 247 Query: 87 LNAFTPQRNLEEFQDVYLVMELMDANLCQVIQM-DLDHDRMSYLLYQM---LC-GIKHLH 141 T QR ++++ E M AN C + + ++ H + L +M +C +++L Sbjct: 248 YGVCTKQR------PIFIITEYM-ANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLE 300 Query: 142 SAGIIHRDLKPSNIVVKADCTLKILDFGLAR---------TAGTTFMMTPYVVTRYYRAP 192 S +HRDL N +V +K+ DFGL+R + G+ F + + P Sbjct: 301 SKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVR-------WSPP 353 Query: 193 EVILGMGYTENVDIWSVGCIMGEMIRGGVL 222 EV++ ++ DIW+ G +M E+ G + Sbjct: 354 EVLMYSKFSSKSDIWAFGVLMWEIYSLGKM 383 >4PDO-A nrPDB Length = 299 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 50/185 (27%), Positives = 86/185 (46%), Gaps = 27/185 (14%) Query: 50 VAIKKLSRPFQNVTHAKRA--YREFKLMKLVNHKNII---GLLNAFTPQRNLEEFQ---- 100 VAIK L + T +R E +M +H NII G+++ + P + E+ Sbjct: 66 VAIKTLKAGY---TEKQRVDFLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGA 122 Query: 101 -DVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKA 159 D +L + + ++ Q++ M L + G+K+L + +HRDL NI+V + Sbjct: 123 LDKFLREKDGEFSVLQLVGM----------LRGIAAGMKYLANMNYVHRDLAARNILVNS 172 Query: 160 DCTLKILDFGLART----AGTTFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGE 215 + K+ DFGL+R T+ + + + APE I +T D+WS G +M E Sbjct: 173 NLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYRKFTSASDVWSFGIVMWE 232 Query: 216 MIRGG 220 ++ G Sbjct: 233 VMTYG 237 >4NFN-A nrPDB Length = 309 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 51/169 (30%), Positives = 85/169 (50%), Gaps = 25/169 (14%) Query: 16 TNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYR-EFKL 74 N+ + R+ L+ IG G G + A D +T++NVA+K ++ K+ + E + Sbjct: 15 ANYVVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALK-----VESAQQPKQVLKMEVAV 69 Query: 75 MKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLY--- 131 +K + K+ + RN E+F Y+VM+L NL + + R ++ L Sbjct: 70 LKKLQGKDHV--CRFIGCGRN-EKFN--YVVMQLQGRNLADLRR---SQPRGTFTLSTTL 121 Query: 132 ----QMLCGIKHLHSAGIIHRDLKPSNIVV-KADCTLK---ILDFGLAR 172 Q+L I+ +HS G +HRD+KPSN + + T + +LDFGLAR Sbjct: 122 RLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLAR 170 >2VWV-A nrPDB Length = 302 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 58/208 (27%), Positives = 87/208 (41%), Gaps = 28/208 (13%) Query: 30 IGSGAQGIVCAA---YDTITQQNVAIKKLSRPFQNVTHAKRAYREF----KLMKLVNHKN 82 IG+G G VC + VAIK L + +R REF +M H N Sbjct: 24 IGAGEFGEVCRGRLKAPGKKESCVAIKTLKG-----GYTERQRREFLSEASIMGQFEHPN 78 Query: 83 II---GLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGIKH 139 II G++ P L EF + + + N Q + L +L + G+++ Sbjct: 79 IIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVIQLVG-----MLRGIASGMRY 133 Query: 140 LHSAGIIHRDLKPSNIVVKADCTLKILDFGLAR-------TAGTTFMMTPYVVTRYYRAP 192 L +HRDL NI+V ++ K+ DFGL+R T + + R+ AP Sbjct: 134 LAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTETSSLGGKIPIRWT-AP 192 Query: 193 EVILGMGYTENVDIWSVGCIMGEMIRGG 220 E I +T D WS G +M E++ G Sbjct: 193 EAIAFRKFTSASDAWSYGIVMWEVMSFG 220 >5O2B-A nrPDB Length = 285 Score = 58.9 bits (141), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 64/237 (27%), Positives = 105/237 (44%), Gaps = 11/237 (4%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNA 89 +G GA V DT T VA +L +R E +++K + H NI+ ++ Sbjct: 24 LGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDS 83 Query: 90 FTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYL---LYQMLCGIKHLHSAG-- 144 + + L+ + + LV ELM + + + L Q+L G++ LH+ Sbjct: 84 W--ESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPP 141 Query: 145 IIHRDLKPSNIVVKADC-TLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGYTEN 203 IIHRDLK NI + ++KI D GLA T+F + + T + APE + Y E+ Sbjct: 142 IIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKS-VIGTPEFMAPE-MYEEHYDES 199 Query: 204 VDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVEN 260 VD+++ G M EM + + Q + + G SF + P V+ +E Sbjct: 200 VDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTS-GIKPASFNKVTDPEVKEIIEG 255 >4BTK-A nrPDB Length = 337 Score = 58.9 bits (141), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 51/169 (30%), Positives = 85/169 (50%), Gaps = 25/169 (14%) Query: 16 TNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYR-EFKL 74 N+ + R+ L+ IG G G + A D +T++NVA+K ++ K+ + E + Sbjct: 50 ANYVVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALK-----VESAQQPKQVLKMEVAV 104 Query: 75 MKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLY--- 131 +K + K+ + RN E+F Y+VM+L NL + + R ++ L Sbjct: 105 LKKLQGKDHV--CRFIGCGRN-EKFN--YVVMQLQGRNLADLRR---SQPRGTFTLSTTL 156 Query: 132 ----QMLCGIKHLHSAGIIHRDLKPSNIVV-KADCTLK---ILDFGLAR 172 Q+L I+ +HS G +HRD+KPSN + + T + +LDFGLAR Sbjct: 157 RLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLAR 205 >2H8H-A nrPDB Length = 535 Score = 58.9 bits (141), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 52/192 (27%), Positives = 92/192 (47%), Gaps = 34/192 (17%) Query: 50 VAIKKLSRPFQNVTHAKRAY-REFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMEL 108 VAIK L + T + A+ +E ++MK + H+ ++ L + + +Y+V E Sbjct: 294 VAIKTL----KPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEE-------PIYIVTEY 342 Query: 109 MD-ANLCQVIQMD----LDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTL 163 M +L ++ + L ++ + Q+ G+ ++ +HRDL+ +NI+V + Sbjct: 343 MSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVC 402 Query: 164 KILDFGLAR-------TA--GTTFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMG 214 K+ DFGLAR TA G F + + APE L +T D+WS G ++ Sbjct: 403 KVADFGLARLIEDNEYTARQGAKFPIK-------WTAPEAALYGRFTIKSDVWSFGILLT 455 Query: 215 EM-IRGGVLFPG 225 E+ +G V +PG Sbjct: 456 ELTTKGRVPYPG 467 >3BGP-A nrPDB Length = 333 Score = 58.9 bits (141), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 54/209 (25%), Positives = 93/209 (44%), Gaps = 25/209 (11%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRP----FQNVTHAKRAYREFKLMKLVNH--KNI 83 +GSG G V + VAIK + + + + + R E L+K V+ + Sbjct: 64 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGV 123 Query: 84 IGLLNAFTPQRNL-------EEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCG 136 I LL+ F + E QD++ + A L + +Q+L Sbjct: 124 IRLLDWFERPDSFVLILERPEPVQDLFDFITERGA---------LQEELARSFFWQVLEA 174 Query: 137 IKHLHSAGIIHRDLKPSNIVVKAD-CTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVI 195 ++H H+ G++HRD+K NI++ + LK++DFG T + T + TR Y PE I Sbjct: 175 VRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDT-VYTDFDGTRVYSPPEWI 233 Query: 196 LGMGY-TENVDIWSVGCIMGEMIRGGVLF 223 Y + +WS+G ++ +M+ G + F Sbjct: 234 RYHRYHGRSAAVWSLGILLYDMVCGDIPF 262 >2H34-A nrPDB Length = 309 Score = 58.9 bits (141), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 68/242 (28%), Positives = 111/242 (45%), Gaps = 18/242 (7%) Query: 28 RPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQ-NVTHAKRAYREFKLMKLVNHKNIIGL 86 R +G G G V A DT+ ++ VA+K +S + R RE + + +++ Sbjct: 40 RLVGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPVFRTRMQREARTAGRLQEPHVV-- 97 Query: 87 LNAFTPQRNLEEFQ-DVYLVMELMDA-NLCQVI--QMDLDHDRMSYLLYQMLCGIKHLHS 142 P + E +Y+ M L++ +L ++ Q L R ++ Q+ + H+ Sbjct: 98 -----PIHDFGEIDGQLYVDMRLINGVDLAAMLRRQGPLAPPRAVAIVRQIGSALDAAHA 152 Query: 143 AGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPY---VVTRYYRAPEVILGMG 199 AG HRD+KP NI+V AD ++DFG+A +A T +T V T YY APE Sbjct: 153 AGATHRDVKPENILVSADDFAYLVDFGIA-SATTDEKLTQLGNTVGTLYYMAPERFSESH 211 Query: 200 YTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVE 259 T DI+++ C++ E + G + G D + I Q P PS ++ P + V Sbjct: 212 ATYRADIYALTCVLYECLTGSPPYQG-DQLSVMGAHINQ-AIPRPSTVRPGIPVAFDAVI 269 Query: 260 NR 261 R Sbjct: 270 AR 271 >1TKI-A nrPDB Length = 321 Score = 58.9 bits (141), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 65/310 (20%), Positives = 134/310 (43%), Gaps = 58/310 (18%) Query: 20 IHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVN 79 ++ +Y+ +G G GIV +T +++ K + + K+ E ++ + Sbjct: 3 LYEKYMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVKGTDQVLVKK---EISILNIAR 59 Query: 80 HKNIIGLLNAFTPQRNLEEFQDVYLVMELMDA-NLCQVIQ---MDLDHDRMSYLLYQMLC 135 H+NI+ L +F E +++ ++ E + ++ + I +L+ + ++Q+ Sbjct: 60 HRNILHLHESF------ESMEELVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCE 113 Query: 136 GIKHLHSAGIIHRDLKPSNIV--VKADCTLKILDFGLAR--TAGTTFMMTPYVVTRYYRA 191 ++ LHS I H D++P NI+ + T+KI++FG AR G F + + YY A Sbjct: 114 ALQFLHSHNIGHFDIRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLL-FTAPEYY-A 171 Query: 192 PEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQ 251 PEV + D+WS+G ++ VL G + P + Q Sbjct: 172 PEVHQHDVVSTATDMWSLGTLV------YVLLSGIN----------------PFLAETNQ 209 Query: 252 PTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISV 311 + N + Y+FD + + + +A + + ++LV + + R++ Sbjct: 210 QIIENIMN-----AEYTFD------------EEAFKEISIEAMDFVDRLLVKERKSRMTA 252 Query: 312 DEALKHEYIN 321 EAL+H ++ Sbjct: 253 SEALQHPWLK 262 >4PWN-A nrPDB Length = 274 Score = 58.5 bits (140), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 61/237 (25%), Positives = 103/237 (43%), Gaps = 10/237 (4%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNA 89 IG G+ V DT T VA +L + +R E +++K + H NI+ ++ Sbjct: 18 IGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQHPNIVRFYDS 77 Query: 90 FTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYL---LYQMLCGIKHLHSAG-- 144 + + ++ + + LV ELM + + ++ L Q+L G++ LH+ Sbjct: 78 W--ESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKGLQFLHTRTPP 135 Query: 145 IIHRDLKPSNIVVKADC-TLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGYTEN 203 IIHRDLK NI + ++KI D GLA + T + APE + Y E+ Sbjct: 136 IIHRDLKCDNIFITGPTGSVKIGDLGLATLEKRASFAKSVIGTPEFMAPE-MYEEKYDES 194 Query: 204 VDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVEN 260 VD+++ G M EM + + Q + + G SF + P V+ +E Sbjct: 195 VDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTS-GVKPASFDKVAIPEVKEIIEG 250 >2OGV-A nrPDB Length = 317 Score = 58.5 bits (140), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 66/239 (27%), Positives = 112/239 (46%), Gaps = 27/239 (11%) Query: 28 RPIGSGAQG-IVCAAYDTITQQNVAIKKLSRPFQNVTHA--KRAY-REFKLMK-LVNHKN 82 + +G+GA G +V A + +++ +K + ++ HA K A E K+M L H+N Sbjct: 44 KTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHEN 103 Query: 83 IIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHD-----RMSYLLY---QML 134 I+ LL A T + + +L++ L + + DLD + + LL+ Q+ Sbjct: 104 IVNLLGACTHGGPVLVITEYCCYGDLLNF-LRRKAEADLDKEDGRPLELRDLLHFSSQVA 162 Query: 135 CGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYR---- 190 G+ L S IHRD+ N+++ KI DFGLAR + Y+V R Sbjct: 163 QGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMND---SNYIVKGNARLPVK 219 Query: 191 --APEVILGMGYTENVDIWSVGCIMGEMIRGGV-LFPGTDHIDQWNKIIE---QLGTPS 243 APE I YT D+WS G ++ E+ G+ +PG ++ K+++ Q+ P+ Sbjct: 220 WMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPA 278 >3OMV-A nrPDB Length = 307 Score = 58.5 bits (140), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 73/262 (27%), Positives = 122/262 (46%), Gaps = 44/262 (16%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYR-EFKLMKLVNHKNIIGLLN 88 IGSG+ G V Y +VA+K L + +A+R E +++ H NI+ L Sbjct: 44 IGSGSFGTV---YKGKWHGDVAVKIL-KVVDPTPEQFQAFRNEVAVLRKTRHVNIL-LFM 98 Query: 89 AFTPQRNLE------EFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGIKHLHS 142 + + NL E +Y + + + Q+ Q+ +D R Q G+ +LH+ Sbjct: 99 GYMTKDNLAIVTQWCEGSSLYKHLHVQETKF-QMFQL-IDIAR------QTAQGMDYLHA 150 Query: 143 AGIIHRDLKPSNIVVKADCTLKILDFGLA----RTAGTTFMMTPYVVTRYYRAPEVILGM 198 IIHRD+K +NI + T+KI DFGLA R +G+ + P + + APEVI Sbjct: 151 KNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQP-TGSVLWMAPEVIRMQ 209 Query: 199 G---YTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLG----TP--------S 243 ++ D++S G ++ E++ G + + HI+ ++II +G +P Sbjct: 210 DNNPFSFQSDVYSYGIVLYELMTGELPY---SHINNRDQIIFMVGRGYASPDLSKLYKNC 266 Query: 244 PSFMQRL-QPTVRNYVENRPRY 264 P M+RL V+ E RP + Sbjct: 267 PKAMKRLVADCVKKVKEERPLF 288 >4Y93-A nrPDB Length = 446 Score = 58.5 bits (140), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 52/208 (25%), Positives = 96/208 (46%), Gaps = 32/208 (15%) Query: 27 LRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGL 86 L+ +G+G G+V Q +VAIK + + E K+M ++H+ ++ L Sbjct: 193 LKELGTGQFGVVKYG-KWRGQYDVAIKMIK---EGSMSEDEFIEEAKVMMNLSHEKLVQL 248 Query: 87 LNAFTPQRNLEEFQDVYLVMELMDANLCQVIQM-DLDHDRMSYLLYQM---LC-GIKHLH 141 T QR ++++ E M AN C + + ++ H + L +M +C +++L Sbjct: 249 YGVCTKQR------PIFIITEYM-ANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLE 301 Query: 142 SAGIIHRDLKPSNIVVKADCTLKILDFGLAR---------TAGTTFMMTPYVVTRYYRAP 192 S +HRDL N +V +K+ DFG+ R + G+ F + + +P Sbjct: 302 SKQFLHRDLAARNCLVNDQGVVKVSDFGMTRYVLDDEYTSSTGSKFPVK-------WASP 354 Query: 193 EVILGMGYTENVDIWSVGCIMGEMIRGG 220 EV++ ++ DIW+ G +M E+ G Sbjct: 355 EVLMYSKFSSKSDIWAFGVLMWEIYSLG 382 >4XUF-A nrPDB Length = 297 Score = 58.5 bits (140), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 65/248 (26%), Positives = 106/248 (42%), Gaps = 47/248 (18%) Query: 28 RPIGSGAQG-IVCAAYDTITQQNVAIK---KLSRPFQNVTHAKRAYREFKLM-KLVNHKN 82 + +GSGA G ++ A I++ V+I+ K+ + + + + E K+M +L +H+N Sbjct: 15 KVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHEN 74 Query: 83 IIGLLNAFTPQRNLEEFQDVYLVMELMD----ANLCQVIQMDLDHDRMSY---------- 128 I+ LL A T +YL+ E N + + D + Y Sbjct: 75 IVNLLGACTLS------GPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRLEEEE 128 Query: 129 ------------LLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGT 176 YQ+ G++ L +HRDL N++V +KI DFGLAR + Sbjct: 129 DLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMS 188 Query: 177 TFMMTPYVVTRYYR------APEVILGMGYTENVDIWSVGCIMGEMIRGGV-LFPGTDHI 229 + YVV R APE + YT D+WS G ++ E+ GV +PG Sbjct: 189 D---SNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVD 245 Query: 230 DQWNKIIE 237 + K+I+ Sbjct: 246 ANFYKLIQ 253 >2Y6O-A nrPDB Length = 291 Score = 58.5 bits (140), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 54/202 (26%), Positives = 83/202 (41%), Gaps = 18/202 (8%) Query: 30 IGSGAQGIVCAAYDTITQQN---VAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGL 86 IG G G VC+ + + VAIK L + + + E +M +H NII L Sbjct: 22 IGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTD-KQRRDFLSEASIMGQFDHPNIIHL 80 Query: 87 LNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGI----KHLHS 142 T + + V ++ E M+ D L ML GI K+L Sbjct: 81 EGVVT------KCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYLSD 134 Query: 143 AGIIHRDLKPSNIVVKADCTLKILDFGLART----AGTTFMMTPYVVTRYYRAPEVILGM 198 +HRDL NI+V ++ K+ DFG++R + + + APE I Sbjct: 135 MSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAYR 194 Query: 199 GYTENVDIWSVGCIMGEMIRGG 220 +T D+WS G +M E++ G Sbjct: 195 KFTSASDVWSYGIVMWEVMSYG 216 >6F3F-A nrPDB Length = 455 Score = 58.2 bits (139), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 58/213 (27%), Positives = 103/213 (48%), Gaps = 37/213 (17%) Query: 30 IGSGAQGIVC-AAYDTITQQNVAIKKLSRPFQNVTHAKRAY-REFKLMKLVNHKNIIGLL 87 +G G G V ++ T+ VAIK L + T + A+ +E ++MK + H+ ++ L Sbjct: 195 LGQGCFGEVWMGTWNGTTR--VAIKTL----KPGTMSPEAFLQEAQVMKKLRHEKLVQLY 248 Query: 88 NAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQMDL-DHDRMSYLL---YQMLCGIKHLHS 142 + + +Y+V E M+ +L ++ + + R+ L+ Q+ G+ ++ Sbjct: 249 AVVSEE-------PIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVER 301 Query: 143 AGIIHRDLKPSNIVVKADCTLKILDFGLAR-------TA--GTTFMMTPYVVTRYYRAPE 193 +HRDL+ +NI+V + K+ DFGLAR TA G F + + APE Sbjct: 302 MNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIK-------WTAPE 354 Query: 194 VILGMGYTENVDIWSVGCIMGEM-IRGGVLFPG 225 L +T D+WS G ++ E+ +G V +PG Sbjct: 355 AALYGRFTIKSDVWSFGILLTELTTKGRVPYPG 387 >6E4F-A nrPDB Length = 290 Score = 58.2 bits (139), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 53/208 (25%), Positives = 96/208 (46%), Gaps = 32/208 (15%) Query: 27 LRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGL 86 L+ +G+G G+V Q +VAIK + + E K+M ++H+ ++ L Sbjct: 36 LKELGTGQFGVVKYG-KWRGQYDVAIKMIK---EGSMSEDEFIEEAKVMMNLSHEKLVQL 91 Query: 87 LNAFTPQRNLEEFQDVYLVMELMDANLCQVIQM-DLDHDRMSYLLYQM---LC-GIKHLH 141 T QR ++++ E M AN C + + ++ H + L +M +C +++L Sbjct: 92 YGVCTKQR------PIFIITEYM-ANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLE 144 Query: 142 SAGIIHRDLKPSNIVVKADCTLKILDFGLAR---------TAGTTFMMTPYVVTRYYRAP 192 S +HRDL N +V +K+ DFGL+R + G+ F + + P Sbjct: 145 SKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVR-------WSPP 197 Query: 193 EVILGMGYTENVDIWSVGCIMGEMIRGG 220 EV++ ++ DIW+ G +M E+ G Sbjct: 198 EVLMYSKFSSKSDIWAFGVLMWEIYSLG 225 >3SXS-A nrPDB Length = 268 Score = 58.2 bits (139), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 50/208 (24%), Positives = 90/208 (43%), Gaps = 32/208 (15%) Query: 27 LRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGL 86 L+ +GSG G+V Q +VA+K + + ++E + M ++H ++ Sbjct: 13 LKELGSGQFGVVKLG-KWKGQYDVAVKMIK---EGSMSEDEFFQEAQTMMKLSHPKLVKF 68 Query: 87 LNAFTPQRNLEEFQDVYLVMELMDANLCQVIQM-----DLDHDRMSYLLYQMLCGIKHLH 141 + + +Y+V E + +N C + + L+ ++ + Y + G+ L Sbjct: 69 YGVCSKEY------PIYIVTEYI-SNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLE 121 Query: 142 SAGIIHRDLKPSNIVVKADCTLKILDFGLAR---------TAGTTFMMTPYVVTRYYRAP 192 S IHRDL N +V D +K+ DFG+ R + GT F + + AP Sbjct: 122 SHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVK-------WSAP 174 Query: 193 EVILGMGYTENVDIWSVGCIMGEMIRGG 220 EV Y+ D+W+ G +M E+ G Sbjct: 175 EVFHYFKYSSKSDVWAFGILMWEVFSLG 202 >2DQ7-X nrPDB Length = 283 Score = 58.2 bits (139), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 54/211 (25%), Positives = 89/211 (42%), Gaps = 32/211 (15%) Query: 49 NVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMEL 108 VAIK L + E ++MK + H ++ L + + +Y+V E Sbjct: 35 KVAIKTLK---PGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEE-------PIYIVTEY 84 Query: 109 MDANLCQVIQMD-----LDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTL 163 M+ D L + + Q+ G+ ++ IHRDL+ +NI+V Sbjct: 85 MNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLIC 144 Query: 164 KILDFGLAR-------TA--GTTFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMG 214 KI DFGLAR TA G F + + APE L +T D+WS G ++ Sbjct: 145 KIADFGLARLIEDNEYTARQGAKFPIK-------WTAPEAALYGRFTIKSDVWSFGILLT 197 Query: 215 EMI-RGGVLFPGTDHIDQWNKIIEQLGTPSP 244 E++ +G V +PG ++ + ++ P P Sbjct: 198 ELVTKGRVPYPGMNNREVLEQVERGYRMPCP 228 >5SYS-A nrPDB Length = 286 Score = 57.8 bits (138), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 55/211 (26%), Positives = 101/211 (47%), Gaps = 34/211 (16%) Query: 50 VAIKKLSRPFQNVTHAKRAY-REFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMEL 108 VAIK L + T + A+ +E ++MK + H+ ++ L + + +Y+V E Sbjct: 45 VAIKTL----KPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEE-------PIYIVTEY 93 Query: 109 MD-ANLCQVIQMDL-DHDRMSYLL---YQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTL 163 M +L ++ ++ + R+ L+ Q+ G+ ++ +HRDL+ +NI+V + Sbjct: 94 MSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVC 153 Query: 164 KILDFGLAR-------TA--GTTFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMG 214 K+ DFGLAR TA G F + + APE L +T D+WS G ++ Sbjct: 154 KVADFGLARLIEDNEYTARQGAKFPIK-------WTAPEAALYGRFTIKSDVWSFGILLT 206 Query: 215 EM-IRGGVLFPGTDHIDQWNKIIEQLGTPSP 244 E+ +G V +PG + + +++ P P Sbjct: 207 ELTTKGRVPYPGMVNREVLDQVERGYRMPCP 237 >6CTH-A nrPDB Length = 309 Score = 57.8 bits (138), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 55/207 (26%), Positives = 88/207 (42%), Gaps = 33/207 (15%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNA 89 +G G G V + + +A+KK+SR + K E K++ + HKN++ L+ Sbjct: 23 LGEGGFGSVYRGFLRDSDTYIAVKKVSRASKQ--GIKEYASEVKIISRLRHKNLVKLIGW 80 Query: 90 FTPQRNLEEFQDVYLVMELM------------DANLCQVIQMDLDHDRMSYLLYQMLCGI 137 E ++ LV E M + L ++ + D S LLY Sbjct: 81 ------CHERGELMLVYEFMANGSLDSHIFKGKSLLTWEVRYRIVKDLASALLY------ 128 Query: 138 KHLHSAG---IIHRDLKPSNIVVKADCTLKILDFGLARTA--GTTFMMTPYVVTRYYRAP 192 LH G ++HRD+K SNI++ + K+ DFGLAR T T Y AP Sbjct: 129 --LHEEGDHCVLHRDIKTSNIMLDSSFNAKLGDFGLARLVDHAKGLKKTLLAGTVGYMAP 186 Query: 193 EVILGMGYTENVDIWSVGCIMGEMIRG 219 E + ++ D++S G + E+ G Sbjct: 187 ECLSSGKASKESDVYSFGVVALEIASG 213 >6J5U-C nrPDB Length = 426 Score = 57.8 bits (138), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 33/89 (37%), Positives = 49/89 (55%), Gaps = 5/89 (5%) Query: 136 GIKHLHSAG--IIHRDLKPSNIVVKADCTLKILDFGLARTAGT---TFMMTPYVVTRYYR 190 G+ LH A +I+RD K +NI++ AD K+ DFGLA+ T T + T + T Y Sbjct: 204 GLTFLHEAKSQVIYRDFKAANILLDADFNAKLSDFGLAKAGPTGDNTHVSTKVIGTHGYA 263 Query: 191 APEVILGMGYTENVDIWSVGCIMGEMIRG 219 APE + T D++S G ++ E+I G Sbjct: 264 APEYVATGRLTAKSDVYSFGVVLLELISG 292 >4JLC-A nrPDB Length = 657 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 62/240 (25%), Positives = 99/240 (41%), Gaps = 35/240 (14%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRA---YREFKLMKLVNHKNIIGL 86 +G GA V T A+K F N++ + REF+++K +NHKNI+ L Sbjct: 16 LGQGATANVFRGRHKKTGDLYAVK----VFNNISFLRPVDVQMREFEVLKKLNHKNIVKL 71 Query: 87 LNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSY---------LLYQMLCGI 137 +EE + +M+ C + L+ +Y +L ++ G+ Sbjct: 72 FA-------IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 124 Query: 138 KHLHSAGIIHRDLKPSNI--VVKAD--CTLKILDFGLARTAGTTFMMTPYVVTRYYRAPE 193 HL GI+HRD+KP NI V+ D K+ DFG AR T Y P+ Sbjct: 125 NHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPD 184 Query: 194 V----IL----GMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPS 245 + +L Y VD+WSVG G + F + + +++ ++ T PS Sbjct: 185 MYERAVLRKDHQKKYGATVDLWSVGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS 244 >5B2L-A nrPDB Length = 324 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 61/229 (26%), Positives = 96/229 (41%), Gaps = 29/229 (12%) Query: 3 TAQHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNV 62 T Q Y E+ D NL +GSG G V T +A+K++ R N Sbjct: 6 TIGGQRYQAEINDLE--------NLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRS-GNK 56 Query: 63 THAKRAYREFKL-MKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN---LCQVIQ 118 KR + + +K + I+ F DV++ MELM + L + +Q Sbjct: 57 EENKRILMDLDVVLKSHDCPYIVQCFGTFITN------TDVFIAMELMGTSAEKLKKRMQ 110 Query: 119 MDLDH---DRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAG 175 + +M+ + + L +K H G+IHRD+KPSNI++ +K+ DFG++ Sbjct: 111 GPIPERILGKMTVAIVKALYYLKEKH--GVIHRDVKPSNILLDERGQIKLCDFGISGRLV 168 Query: 176 TTFMMTPYVVTRYYRAPEVI-----LGMGYTENVDIWSVGCIMGEMIRG 219 + T Y APE I Y D+WS+G + E+ G Sbjct: 169 DSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATG 217 >4AT3-A nrPDB Length = 299 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 57/220 (25%), Positives = 98/220 (44%), Gaps = 38/220 (17%) Query: 28 RPIGSGAQGIVCAA--YDTITQQN---VAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKN 82 R +G GA G V A Y+ +Q+ VA+K L N K +RE +L+ + H++ Sbjct: 19 RELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNAR--KDFHREAELLTNLQHEH 76 Query: 83 II---GLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQM-------DLDHDRMSYLLYQ 132 I+ G+ P + E+ + + + A+ + M +L +M ++ Q Sbjct: 77 IVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQ 136 Query: 133 MLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRA- 191 + G+ +L S +HRDL N +V + +KI DFG++R + T YYR Sbjct: 137 IAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYS---------TDYYRVG 187 Query: 192 -----------PEVILGMGYTENVDIWSVGCIMGEMIRGG 220 PE I+ +T D+WS+G ++ E+ G Sbjct: 188 GHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYG 227 >4OTD-A nrPDB Length = 341 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 48/163 (29%), Positives = 78/163 (47%), Gaps = 11/163 (6%) Query: 78 VNHKNIIGLLNAF-TPQRNLEEFQDVYLVMEL-MDANLCQVIQMDL-DHDRMSYLLYQML 134 H ++ L F TP+ V VME +L I D+ R + ++ Sbjct: 72 AGHPFLVNLFGCFQTPEH-------VCFVMEYSAGGDLMLHIHSDVFSEPRAIFYSACVV 124 Query: 135 CGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTA-GTTFMMTPYVVTRYYRAPE 193 G++ LH I++RDLK N+++ + +KI DFGL + G + + T + APE Sbjct: 125 LGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPE 184 Query: 194 VILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKII 236 V+ YT VD W +G ++ EM+ G FPG D + ++ I+ Sbjct: 185 VLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIV 227 >6DBN-A nrPDB Length = 316 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 60/234 (25%), Positives = 102/234 (43%), Gaps = 46/234 (19%) Query: 10 TVEVGDTNFTIHSRYIN-LRPIGSGAQGIV-CAAYDTI---TQQNVAIKKLSRPFQNVTH 64 EV T+F R++ +R +G G G V YD T + VA+K L +P H Sbjct: 24 ATEVDPTHF--EKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSL-KPESGGNH 80 Query: 65 AKRAYREFKLMKLVNHKNI--------------IGLLNAFTPQRNLEEFQDVYLVMELMD 110 +E ++++ + H+NI I L+ F P +L+E YL Sbjct: 81 IADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKE----YLPKNKNK 136 Query: 111 ANLCQVIQMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGL 170 NL Q ++ + Q+ G+ +L S +HRDL N++V+++ +KI DFGL Sbjct: 137 INLKQQLKYAV----------QICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGL 186 Query: 171 ARTAGTTFMMTPYVVTR-------YYRAPEVILGMGYTENVDIWSVGCIMGEMI 217 + T Y + ++ APE ++ + D+WS G + E++ Sbjct: 187 TKAIETD---KEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELL 237 >3HNG-A nrPDB Length = 360 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 38/111 (34%), Positives = 56/111 (50%), Gaps = 11/111 (9%) Query: 123 HDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTP 182 D +SY +Q+ G++ L S IHRDL NI++ + +KI DFGLAR + Sbjct: 199 EDLISYS-FQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLAR---DIYKNPD 254 Query: 183 YV------VTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGT 226 YV + + APE I Y+ D+WS G ++ E+ GG +PG Sbjct: 255 YVRKGDTRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSPYPGV 305 >4Y83-A nrPDB Length = 332 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 60/228 (26%), Positives = 104/228 (45%), Gaps = 26/228 (11%) Query: 1 MTTAQHQHYTVEVGDTNFTIHSRYINLRPIGS-----GAQGIVCAAYDTITQQNVAIKKL 55 + T Q+ Y + D++ + + R IGS GA G V A D T++ +A K + Sbjct: 50 VITPQNGRYQI---DSDVLLIPWKLTYRNIGSDFIPRGAFGKVYLAQDIKTKKRMACKLI 106 Query: 56 SRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVY---LVMELMDAN 112 V K + + ++ H+NI L A + F + V+E +++ Sbjct: 107 P-----VDQFKPS--DVEIQACFRHENIAELYGAVLWGETVHLFMEAGEGGSVLEKLES- 158 Query: 113 LCQVIQMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLA- 171 C ++ + ++ +L G+ LHS +IH D+KPSNIV + + ++DFGL+ Sbjct: 159 -CGPMR----EFEIIWVTKHVLKGLDFLHSKKVIHHDIKPSNIVFMSTKAV-LVDFGLSV 212 Query: 172 RTAGTTFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRG 219 + + T Y +PEVIL G++ DI+S+G + M G Sbjct: 213 QMTEDVYFPKDLRGTEIYMSPEVILCRGHSTKADIYSLGATLIHMQTG 260 >3BEA-A nrPDB Length = 333 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 64/243 (26%), Positives = 110/243 (45%), Gaps = 31/243 (12%) Query: 28 RPIGSGAQG-IVCAAYDTITQQNVAIKKLSRPFQNVTHA--KRAY-REFKLMK-LVNHKN 82 + +G+GA G +V A + +++ +K + ++ HA K A E K+M L H+N Sbjct: 52 KTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHEN 111 Query: 83 IIGLLNAFT---PQRNLEEFQDVYLVMELMDANLCQVIQMD---------LDHDRMSYLL 130 I+ LL A T P + E+ ++ + +V++ D L + + Sbjct: 112 IVNLLGACTHGGPVLVITEYCCYGDLLNFLRRK-SRVLETDPAFAIANSTLSTRDLLHFS 170 Query: 131 YQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYR 190 Q+ G+ L S IHRD+ N+++ KI DFGLAR + Y+V R Sbjct: 171 SQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMND---SNYIVKGNAR 227 Query: 191 ------APEVILGMGYTENVDIWSVGCIMGEMIRGGV-LFPGTDHIDQWNKIIE---QLG 240 APE I YT D+WS G ++ E+ G+ +PG ++ K+++ Q+ Sbjct: 228 LPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMA 287 Query: 241 TPS 243 P+ Sbjct: 288 QPA 290 >3MY0-A nrPDB Length = 305 Score = 55.8 bits (133), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 60/240 (25%), Positives = 102/240 (42%), Gaps = 50/240 (20%) Query: 77 LVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQMDLDHDRMSY-LLYQML 134 L+ H NI+G + + RN ++L+ + +L +Q ++ L Sbjct: 58 LLRHDNILGFIASDMTSRN--SSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAA 115 Query: 135 CGIKHLH--------SAGIIHRDLKPSNIVVKADCTLKILDFGLA--RTAGTTFM---MT 181 CG+ HLH I HRD K N++VK++ I D GLA + G+ ++ Sbjct: 116 CGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNN 175 Query: 182 PYVVTRYYRAPEVILGMGYTEN------VDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKI 235 P V T+ Y APEV+ T+ DIW+ G ++ E+ R ++ N I Sbjct: 176 PRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIV----------NGI 225 Query: 236 IEQLGTP-------SPSF--MQRL------QPTVRNYVENRPRYTGYSFDRLFPDGLFPN 280 +E P PSF M+++ PT+ N + P +G + ++ + +PN Sbjct: 226 VEDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLA--QMMRECWYPN 283 >4EUT-A nrPDB Length = 396 Score = 55.8 bits (133), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 61/240 (25%), Positives = 99/240 (41%), Gaps = 35/240 (14%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRA---YREFKLMKLVNHKNIIGL 86 +G GA V T AIK F N++ + REF+++K +NHKNI+ L Sbjct: 17 LGQGATANVFRGRHKKTGDLFAIKV----FNNISFLRPVDVQMREFEVLKKLNHKNIVKL 72 Query: 87 LNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSY---------LLYQMLCGI 137 +EE + +M+ C + L+ +Y +L ++ G+ Sbjct: 73 FA-------IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 125 Query: 138 KHLHSAGIIHRDLKPSNI--VVKAD--CTLKILDFGLARTAGTTFMMTPYVVTRYYRAPE 193 HL GI+HR++KP NI V+ D K+ DFG AR T Y P+ Sbjct: 126 NHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPD 185 Query: 194 V----IL----GMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPS 245 + +L Y VD+WS+G G + F + + +++ ++ T PS Sbjct: 186 MYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS 245 >3V5Q-A nrPDB Length = 297 Score = 55.8 bits (133), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 64/244 (26%), Positives = 101/244 (41%), Gaps = 49/244 (20%) Query: 14 GDTNFTIHSRYINLRPI------GSGAQGIVCAA-----YDTITQQNVAIKKLSRPFQNV 62 G + IH ++I R I G GA G V A T + VA+K L P + Sbjct: 1 GAMHSGIHVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDP--TL 58 Query: 63 THAKRAYREFKLMKLVNHKNIIGLLNA------------FTPQRNLEEFQDVYL--VMEL 108 K RE +L+ + H++I+ + +L +F + M L Sbjct: 59 AARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMIL 118 Query: 109 MDANLCQVIQMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDF 168 +D Q + +L +M ++ Q+ G+ +L S +HRDL N +V A+ +KI DF Sbjct: 119 VDGQPRQA-KGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDF 177 Query: 169 GLARTAGTTFMMTPYVVTRYYRA------------PEVILGMGYTENVDIWSVGCIMGEM 216 G++R + T YYR PE I+ +T D+WS G I+ E+ Sbjct: 178 GMSRDVYS---------TDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEI 228 Query: 217 IRGG 220 G Sbjct: 229 FTYG 232 >5O0Y-A nrPDB Length = 579 Score = 55.5 bits (132), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 61/233 (26%), Positives = 102/233 (43%), Gaps = 36/233 (15%) Query: 19 TIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIK-----KLSRPFQNVTHAKRAYREFK 73 T++ RY+ L +G G V A+D Q+ VA+K K R + + K A RE++ Sbjct: 281 TLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYR 340 Query: 74 LMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQM 133 + K ++H I+ L + F+ + + F V E D + + ++ Q+ Sbjct: 341 IHKELDHPRIVKLYDYFS--LDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQI 398 Query: 134 LCGIKHLHSAG--IIHRDLKPSNIVV---KADCTLKILDFGLART--------------- 173 + +K+L+ IIH DLKP NI++ A +KI DFGL++ Sbjct: 399 VNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELT 458 Query: 174 ---AGTTFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLF 223 AGT + + P P++ + VD+WSVG I + + G F Sbjct: 459 SQGAGTYWYLPPECFVVGKEPPKI------SNKVDVWSVGVIFYQCLYGRKPF 505 >6NT9-A nrPDB Length = 742 Score = 55.5 bits (132), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 63/237 (26%), Positives = 99/237 (41%), Gaps = 29/237 (12%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRA---YREFKLMKLVNHKNIIGL 86 +G GA V T AIK F N++ + REF+++K +NHKNI+ L Sbjct: 15 LGQGATANVFRGRHKKTGDLFAIK----VFNNISFLRPVDVQMREFEVLKKLNHKNIVKL 70 Query: 87 LNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQ-----MDLDHDRMSYLLYQMLCGIKHL 140 F + V L+ME +L V++ L +L ++ G+ HL Sbjct: 71 ---FAIEEETTTRHKV-LIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 126 Query: 141 HSAGIIHRDLKPSNI--VVKAD--CTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEV-- 194 GI+HR++KP NI V+ D K+ DFG AR T Y P++ Sbjct: 127 RENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYE 186 Query: 195 --IL----GMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPS 245 +L Y VD+WS+G G + F + + +++ ++ T PS Sbjct: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS 243 >4EUU-A nrPDB Length = 319 Score = 55.1 bits (131), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 61/240 (25%), Positives = 99/240 (41%), Gaps = 35/240 (14%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRA---YREFKLMKLVNHKNIIGL 86 +G GA V T AIK F N++ + REF+++K +NHKNI+ L Sbjct: 17 LGQGATANVFRGRHKKTGDLFAIKV----FNNISFLRPVDVQMREFEVLKKLNHKNIVKL 72 Query: 87 LNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSY---------LLYQMLCGI 137 +EE + +M+ C + L+ +Y +L ++ G+ Sbjct: 73 FA-------IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 125 Query: 138 KHLHSAGIIHRDLKPSNI--VVKAD--CTLKILDFGLARTAGTTFMMTPYVVTRYYRAPE 193 HL GI+HR++KP NI V+ D K+ DFG AR T Y P+ Sbjct: 126 NHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPD 185 Query: 194 V----IL----GMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPS 245 + +L Y VD+WS+G G + F + + +++ ++ T PS Sbjct: 186 MYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS 245 >6O8B-A nrPDB Length = 665 Score = 55.1 bits (131), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 61/240 (25%), Positives = 99/240 (41%), Gaps = 35/240 (14%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRA---YREFKLMKLVNHKNIIGL 86 +G GA V T AIK F N++ + REF+++K +NHKNI+ L Sbjct: 23 LGQGATANVFRGRHKKTGDLFAIK----VFNNISFLRPVDVQMREFEVLKKLNHKNIVKL 78 Query: 87 LNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSY---------LLYQMLCGI 137 +EE + +M+ C + L+ +Y +L ++ G+ Sbjct: 79 FA-------IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 131 Query: 138 KHLHSAGIIHRDLKPSNI--VVKAD--CTLKILDFGLARTAGTTFMMTPYVVTRYYRAPE 193 HL GI+HR++KP NI V+ D K+ DFG AR T Y P+ Sbjct: 132 NHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVELYGTEEYLHPD 191 Query: 194 V----IL----GMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPS 245 + +L Y VD+WS+G G + F + + +++ ++ T PS Sbjct: 192 MYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS 251 >5E8V-A nrPDB Length = 316 Score = 55.1 bits (131), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 56/191 (29%), Positives = 85/191 (44%), Gaps = 27/191 (14%) Query: 48 QNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVME 107 + VA+K P++ K F + L H+NI+ L A +R E + +L+ Sbjct: 39 ETVAVKIF--PYEEYASWKTEKDIFSDINL-KHENILQFLTA--EERKTELGKQYWLITA 93 Query: 108 L-MDANLCQVIQMD-LDHDRMSYLLYQMLCGIKHLHS---------AGIIHRDLKPSNIV 156 NL + + + + + L + GI HLHS I+HRDLK SNI+ Sbjct: 94 FHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNIL 153 Query: 157 VKADCTLKILDFGLARTAGTTFMM-----TPYVVTRYYRAPEVILGMGYTENV------D 205 VK D T + DFGL+ T + + V T Y APEV+ ENV D Sbjct: 154 VKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLASAMNLENVESFKQTD 213 Query: 206 IWSVGCIMGEM 216 ++S+ ++ EM Sbjct: 214 VYSMALVLWEM 224 >3QGY-A nrPDB Length = 286 Score = 54.7 bits (130), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 64/261 (24%), Positives = 111/261 (42%), Gaps = 42/261 (16%) Query: 27 LRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGL 86 ++ IGSG G+V Y + + VAIK + + E ++M ++H ++ L Sbjct: 32 VQEIGSGQFGLVHLGY-WLNKDKVAIKTIK---EGSMSEDDFIEEAEVMMKLSHPKLVQL 87 Query: 87 LNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQMDLDHDRMSYLLYQML--C-GIKHLHS 142 Q + LV E M+ L ++ LL L C G+ +L Sbjct: 88 YGVCLEQ------APICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEE 141 Query: 143 AGIIHRDLKPSNIVVKADCTLKILDFGLAR---------TAGTTFMMTPYVVTRYYRAPE 193 A +IHRDL N +V + +K+ DFG+ R + GT F + + +PE Sbjct: 142 ACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVK-------WASPE 194 Query: 194 VILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPT 253 V Y+ D+WS G +M E+ G + P + + ++++E + T + RL T Sbjct: 195 VFSFSRYSSKSDVWSFGVLMWEVFSEGKI-PYENRSN--SEVVEDISTGFRLYKPRLAST 251 Query: 254 ----VRNYV-----ENRPRYT 265 + N+ E+RP ++ Sbjct: 252 HVYQIMNHCWKERPEDRPAFS 272 >3KRL-A nrPDB Length = 335 Score = 54.7 bits (130), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 63/244 (25%), Positives = 107/244 (43%), Gaps = 31/244 (12%) Query: 28 RPIGSGAQG-IVCAAYDTITQQNVAIKKLSRPFQNVTHA--KRAY-REFKLMK-LVNHKN 82 + +G+GA G +V A + +++ +K + ++ HA K A E K+M L H+N Sbjct: 52 KTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHEN 111 Query: 83 IIGLLNAFT---PQRNLEEFQDVYLVMELM----------DANLCQVIQMDLDHDRMSYL 129 I+ LL A T P + E+ ++ + N + L + + Sbjct: 112 IVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKRPPGLEYSYNPSHNPEEQLSSRDLLHF 171 Query: 130 LYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYY 189 Q+ G+ L S IHRD+ N+++ KI DFGLAR + Y+V Sbjct: 172 SSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMND---SNYIVKGNA 228 Query: 190 R------APEVILGMGYTENVDIWSVGCIMGEMIRGGV-LFPGTDHIDQWNKIIE---QL 239 R APE I YT D+WS G ++ E+ G+ +PG ++ K+++ Q+ Sbjct: 229 RLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQM 288 Query: 240 GTPS 243 P+ Sbjct: 289 AQPA 292 >1K9A-A nrPDB Length = 450 Score = 54.7 bits (130), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 53/204 (25%), Positives = 88/204 (43%), Gaps = 19/204 (9%) Query: 27 LRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGL 86 L+ IG G G V VA+K + +N A+ E +M + H N++ L Sbjct: 198 LQTIGKGEFGDVMLG--DYRGNKVAVKCI----KNDATAQAFLAEASVMTQLRHSNLVQL 251 Query: 87 LNAFTPQRNLEEFQDVYLVMELM-DANLCQVIQMD----LDHDRMSYLLYQMLCGIKHLH 141 L +EE +Y+V E M +L ++ L D + + +++L Sbjct: 252 LGVI-----VEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE 306 Query: 142 SAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGYT 201 +HRDL N++V D K+ DFGL + A +T V + APE + ++ Sbjct: 307 GNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVK--WTAPEALREKKFS 364 Query: 202 ENVDIWSVGCIMGEMIR-GGVLFP 224 D+WS G ++ E+ G V +P Sbjct: 365 TKSDVWSFGILLWEIYSFGRVPYP 388 >3Q4U-A nrPDB Length = 301 Score = 54.7 bits (130), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 59/215 (27%), Positives = 92/215 (42%), Gaps = 32/215 (14%) Query: 27 LRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMK--LVNHKNII 84 L +G G G V + +NVA+K S K +RE +L ++ H+NI+ Sbjct: 13 LECVGKGRYGEVWRG--SWQGENVAVKIFSS-----RDEKSWFRETELYNTVMLRHENIL 65 Query: 85 GLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQMD-LDHDRMSYLLYQMLCGIKHLH- 141 G + + R+ ++L+ + +L +Q+ LD ++ + G+ HLH Sbjct: 66 GFIASDMTSRH--SSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHI 123 Query: 142 -------SAGIIHRDLKPSNIVVKADCTLKILDFGLA-----RTAGTTFMMTPYVVTRYY 189 I HRDLK NI+VK + I D GLA T P V T+ Y Sbjct: 124 EIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRY 183 Query: 190 RAPEV------ILGMGYTENVDIWSVGCIMGEMIR 218 APEV + + VDIW+ G ++ E+ R Sbjct: 184 MAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVAR 218 >5GNK-A nrPDB Length = 297 Score = 54.3 bits (129), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 56/209 (26%), Positives = 89/209 (42%), Gaps = 17/209 (8%) Query: 22 SRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAK---RAYREFKLMKLV 78 + + ++ +GSGA G V + V I + + T K E +M V Sbjct: 19 TEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASV 78 Query: 79 NHKNIIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQMDLDHDRMSYLL---YQML 134 ++ ++ LL V L+M+LM L ++ D+ YLL Q+ Sbjct: 79 DNPHVCRLLGICLTS-------TVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIA 131 Query: 135 CGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGT---TFMMTPYVVTRYYRA 191 G+ +L ++HRDL N++VK +KI DFGLA+ G + V + A Sbjct: 132 KGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMA 191 Query: 192 PEVILGMGYTENVDIWSVGCIMGEMIRGG 220 E IL YT D+WS G + E++ G Sbjct: 192 LESILHRIYTHQSDVWSYGVTVWELMTFG 220 >4RT7-A nrPDB Length = 415 Score = 54.3 bits (129), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 38/114 (33%), Positives = 56/114 (49%), Gaps = 10/114 (8%) Query: 131 YQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYR 190 YQ+ G++ L +HRDL N++V +KI DFGLAR + + YVV R Sbjct: 250 YQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSD---SNYVVRGNAR 306 Query: 191 ------APEVILGMGYTENVDIWSVGCIMGEMIRGGV-LFPGTDHIDQWNKIIE 237 APE + YT D+WS G ++ E+ GV +PG + K+I+ Sbjct: 307 LPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQ 360 >3SOC-A nrPDB Length = 322 Score = 53.9 bits (128), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 58/232 (25%), Positives = 105/232 (45%), Gaps = 38/232 (16%) Query: 11 VEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYR 70 V++G N S + L + + + C + + VA+K P Q+ + Y Sbjct: 12 VDLGTENLYFQSMPLQLLEVKARGR-FGCVWKAQLLNEYVAVKIF--PIQDKQSWQNEYE 68 Query: 71 EFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVM---------ELMDAN------LCQ 115 + L + H+NI+ + A +R D++L+ + + AN LC Sbjct: 69 VYSLPGM-KHENILQFIGA--EKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCH 125 Query: 116 VIQMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLA---- 171 + + R L++ + G+K H I HRD+K N+++K + T I DFGLA Sbjct: 126 IAET---MARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFE 182 Query: 172 --RTAGTTFMMTPYVVTRYYRAPEVILG-MGYTEN----VDIWSVGCIMGEM 216 ++AG T V TR Y APEV+ G + + + +D++++G ++ E+ Sbjct: 183 AGKSAGDTH---GQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWEL 231 >5WNO-A nrPDB Length = 330 Score = 53.9 bits (128), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 62/261 (23%), Positives = 109/261 (41%), Gaps = 36/261 (13%) Query: 28 RPIGSGAQGIVCAA-YDTITQQNVAIKKLSRPFQN--------VTHAKRAYRE-----FK 73 + +G+GA G V A Y +NV I + FQ + A +R K Sbjct: 28 KKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTDQSQTDEMLEEATNMFRLRHDNLLK 87 Query: 74 LMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQM 133 ++ H + + ++ + P NL+ F ++L NL Q+ YQ+ Sbjct: 88 IIGFCMHDDGLKIVTIYRPLGNLQNF------LKLHKENLGAREQV--------LYCYQI 133 Query: 134 LCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLART----AGTTFMMTPYVVTRYY 189 G+++L ++HRDL N++VK ++I DFGL++ A + + + V ++ Sbjct: 134 ASGMQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWL 193 Query: 190 RAPEVILGMGYTENVDIWSVGCIMGEMIR-GGVLFPG--TDHIDQWNKIIEQLGTPSPSF 246 A E+ YT D+W+ G E+I G + G TD I + K +L P Sbjct: 194 -AIEIFSKHCYTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQPPNCS 252 Query: 247 MQRLQPTVRNYVENRPRYTGY 267 Q +R ++ + G+ Sbjct: 253 QDLYQELLRCWMADPKSRPGF 273 >1BYG-A nrPDB Length = 278 Score = 53.9 bits (128), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 51/199 (25%), Positives = 85/199 (42%), Gaps = 18/199 (9%) Query: 27 LRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGL 86 L+ IG G G V VA+K + +N A+ E +M + H N++ L Sbjct: 26 LQTIGKGEFGDVMLG--DYRGNKVAVKCI----KNDATAQAFLAEASVMTQLRHSNLVQL 79 Query: 87 LNAFTPQRNLEEFQDVYLVMELM-DANLCQVIQMD----LDHDRMSYLLYQMLCGIKHLH 141 L +EE +Y+V E M +L ++ L D + + +++L Sbjct: 80 LGVI-----VEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE 134 Query: 142 SAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGYT 201 +HRDL N++V D K+ DFGL + A +T V + APE + ++ Sbjct: 135 GNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVK--WTAPEALREKKFS 192 Query: 202 ENVDIWSVGCIMGEMIRGG 220 D+WS G ++ E+ G Sbjct: 193 TKSDVWSFGILLWEIYSFG 211 >3VHK-A nrPDB Length = 368 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 35/103 (33%), Positives = 50/103 (48%), Gaps = 10/103 (9%) Query: 131 YQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYV------ 184 +Q+ G++ L S IHRDL NI++ +KI DFGLAR + YV Sbjct: 207 FQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLAR---DIYKDPDYVRKGDAR 263 Query: 185 VTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGT 226 + + APE I YT D+WS G ++ E+ G +PG Sbjct: 264 LPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGV 306 >5HLW-A nrPDB Length = 299 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 63/275 (22%), Positives = 116/275 (42%), Gaps = 32/275 (11%) Query: 11 VEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQN-----VAIKKLSRPFQNVTHA 65 V +G ++ +H + IG G G C + T+ + A+K L+R ++ Sbjct: 13 VVIGPSSLIVHFNEV----IGRGHFG--CVYHGTLLDNDGKKIHCAVKSLNR-ITDIGEV 65 Query: 66 KRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDR 125 + E +MK +H N++ LL E + ++ + +L I+ + + Sbjct: 66 SQFLTEGIIMKDFSHPNVLSLLGICLRS----EGSPLVVLPYMKHGDLRNFIRNETHNPT 121 Query: 126 MSYLL---YQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAG-----TT 177 + L+ Q+ G+K+L S +HRDL N ++ T+K+ DFGLAR + Sbjct: 122 VKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMHDKEYYSV 181 Query: 178 FMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGE-MIRGGVLFPGTDHID------ 230 T + + A E + +T D+WS G ++ E M RG +P + D Sbjct: 182 HNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLL 241 Query: 231 QWNKIIEQLGTPSPSFMQRLQPTVRNYVENRPRYT 265 Q ++++ P P + L+ E RP ++ Sbjct: 242 QGRRLLQPEYCPDPLYEVMLK-CWHPKAEMRPSFS 275 >4M66-A nrPDB Length = 325 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 50/204 (24%), Positives = 97/204 (47%), Gaps = 23/204 (11%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNA 89 +G G G+V A+ +VA+K + ++K+ E K M + ++N++ LL Sbjct: 28 VGKGGFGVVFRAHHRTWNHDVAVK--------IVNSKKISWEVKAMVNLRNENVL-LLLG 78 Query: 90 FTPQRNLEEFQDVYLVMELMD-ANLCQVIQMDLDHD--RMSYLLYQMLCGIKHLHS--AG 144 T + LV M+ +L ++Q + + LL +++ G+ +LHS Sbjct: 79 VTEDLQWDFVSGQALVTRFMENGSLAGLLQPEAPRPWPLLCRLLQEVVLGMCYLHSLDPP 138 Query: 145 IIHRDLKPSNIVVKADCTLKILDFGLA-------RTAGTTFMMTPYVVTRYYRAPEVI-- 195 ++HRDLKPSNI++ + K+ DFGL+ +G+ T Y PE++ Sbjct: 139 LLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQSGSGSGSGSRDSGGTLAYLDPELLFK 198 Query: 196 LGMGYTENVDIWSVGCIMGEMIRG 219 + + ++ D++S G ++ ++ G Sbjct: 199 VNLKASKASDVYSFGILVWAVLAG 222 >5TE0-A nrPDB Length = 347 Score = 52.8 bits (125), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 55/184 (29%), Positives = 83/184 (45%), Gaps = 29/184 (15%) Query: 55 LSRPFQNVTH-AKRAYREFKLMK-LVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMD-- 110 L R F N H + RE ++M+ L HKNI+G +++ N DV+ V+ LMD Sbjct: 48 LKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDS---SINNVSSGDVWEVLILMDFC 104 Query: 111 --ANLCQVIQMDLDHDRMSYLLYQMLC----GIKHLHSAG--IIHRDLKPSNIVVKADCT 162 + ++ L + Q+ C + LH IIHRDLK NI++ Sbjct: 105 RGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGH 164 Query: 163 LKILDFGLA-------RTAGTTFM---MTPYVVTRYYRAPEVI---LGMGYTENVDIWSV 209 + DFG A +T G + + Y T YRAPE++ G T DIW++ Sbjct: 165 YVLCDFGSATNKFQNPQTEGVNAVEDEIKKY-TTLSYRAPEMVNLYSGKIITTKADIWAL 223 Query: 210 GCIM 213 GC++ Sbjct: 224 GCLL 227 >3ZZW-A nrPDB Length = 289 Score = 52.8 bits (125), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 47/191 (24%), Positives = 87/191 (45%), Gaps = 19/191 (9%) Query: 48 QNVAIKKLSRPFQNVTHAKRAYR-EFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDV---- 102 Q VAIK L + + +R E L + H N++ LL T + L Sbjct: 40 QAVAIKTLKDKAEGPL--REEFRHEAMLRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHG 97 Query: 103 ----YLVMELMDANLC-----QVIQMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPS 153 +LVM +++ + ++ L+ +L+ Q+ G+++L S ++H+DL Sbjct: 98 DLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVHLVAQIAAGMEYLSSHHVVHKDLATR 157 Query: 154 NIVVKADCTLKILDFGLAR---TAGTTFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVG 210 N++V +KI D GL R A ++ ++ + APE I+ ++ + DIWS G Sbjct: 158 NVLVYDKLNVKISDLGLFREVYAADYYKLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYG 217 Query: 211 CIMGEMIRGGV 221 ++ E+ G+ Sbjct: 218 VVLWEVFSYGL 228 >3C1X-A nrPDB Length = 373 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 63/275 (22%), Positives = 115/275 (41%), Gaps = 32/275 (11%) Query: 11 VEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQN-----VAIKKLSRPFQNVTHA 65 V +G ++ +H + IG G G C + T+ + A+K L+R ++ Sbjct: 82 VVIGPSSLIVHFNEV----IGRGHFG--CVYHGTLLDNDGKKIHCAVKSLNR-ITDIGEV 134 Query: 66 KRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDR 125 + E +MK +H N++ LL E + ++ + +L I+ + + Sbjct: 135 SQFLTEGIIMKDFSHPNVLSLLGICL----RSEGSPLVVLPYMKHGDLRNFIRNETHNPT 190 Query: 126 MSYLL---YQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTA-----GTT 177 + L+ Q+ G+K L S +HRDL N ++ T+K+ DFGLAR + Sbjct: 191 VKDLIGFGLQVAKGMKFLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEFDSV 250 Query: 178 FMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGE-MIRGGVLFPGTDHID------ 230 T + + A E + +T D+WS G ++ E M RG +P + D Sbjct: 251 HNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLL 310 Query: 231 QWNKIIEQLGTPSPSFMQRLQPTVRNYVENRPRYT 265 Q ++++ P P + L+ E RP ++ Sbjct: 311 QGRRLLQPEYCPDPLYEVMLK-CWHPKAEMRPSFS 344 >4R7H-A nrPDB Length = 343 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 65/251 (25%), Positives = 112/251 (44%), Gaps = 38/251 (15%) Query: 28 RPIGSGAQG-IVCAAYDTITQQNVAIKKLSRPFQNVTHA--KRAY-REFKLMK-LVNHKN 82 + +G+GA G +V A + +++ +K + ++ HA K A E K+M L H+N Sbjct: 56 KTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHEN 115 Query: 83 IIGLLNAFT---PQRNLEEFQDVYLVMELM----DANLCQVIQ-------MDLDHDR--- 125 I+ LL A T P + E+ ++ + +A L + +D + R Sbjct: 116 IVNLLGACTHGGPVLVITEYCTYGDLLNFLRRKAEAMLGPSLSPGQDPEGLDKEDGRPLE 175 Query: 126 ---MSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTP 182 + + Q+ G+ L S IHRD+ N+++ KI DFGLAR + Sbjct: 176 LRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMND---SN 232 Query: 183 YVVTRYYR------APEVILGMGYTENVDIWSVGCIMGEMIRGGV-LFPGTDHIDQWNKI 235 Y+V R APE I YT D+WS G ++ E+ G+ +PG ++ K+ Sbjct: 233 YIVKGNARLPVKWMAPESIFDSVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKL 292 Query: 236 IE---QLGTPS 243 ++ Q+ P+ Sbjct: 293 VKDGYQMAQPA 303 >5TOS-A nrPDB Length = 395 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 31/89 (34%), Positives = 49/89 (55%), Gaps = 5/89 (5%) Query: 136 GIKHLHS--AGIIHRDLKPSNIVVKADCTLKILDFGLAR---TAGTTFMMTPYVVTRYYR 190 G+ LHS +I+RD+K SNI++ AD K+ DFGLAR +++ T + T Y Sbjct: 187 GLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYA 246 Query: 191 APEVILGMGYTENVDIWSVGCIMGEMIRG 219 APE + D++S G ++ E++ G Sbjct: 247 APEYMSSGHLNARSDVYSFGVLLLEILSG 275 >3G2F-A nrPDB Length = 336 Score = 52.4 bits (124), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 64/228 (28%), Positives = 99/228 (43%), Gaps = 36/228 (15%) Query: 27 LRPIGSGAQGIVCAAYDTITQQNVAIKKLSRP-FQNVTHAKRAYREFKLMKLVNHKNIIG 85 L IG G G V ++ ++ VA+K S QN + K YR + L+ H NI Sbjct: 18 LELIGRGRYGAVYKG--SLDERPVAVKVFSFANRQNFINEKNIYR----VPLMEHDNIAR 71 Query: 86 LLNAFTPQRNLEEFQDVYLVMELM-DANLCQVIQMDL-DHDRMSYLLYQMLCGIKHLHSA 143 + + + + LVME + +LC+ + + D L + + G+ +LH+ Sbjct: 72 FIVG-DERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTE 130 Query: 144 ---------GIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTP---------YVV 185 I HRDL N++VK D T I DFGL+ ++ P V Sbjct: 131 LPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPGEEDNAAISEVG 190 Query: 186 TRYYRAPEVILGM-------GYTENVDIWSVGCIMGEM-IRGGVLFPG 225 T Y APEV+ G + VD++++G I E+ +R LFPG Sbjct: 191 TIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPG 238 >3QUP-A nrPDB Length = 323 Score = 52.0 bits (123), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 32/106 (30%), Positives = 54/106 (50%), Gaps = 4/106 (3%) Query: 135 CGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRY---YRA 191 CG+++L S IHRDL N ++ D T+ + DFGL+R + ++ + A Sbjct: 148 CGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLA 207 Query: 192 PEVILGMGYTENVDIWSVGCIMGE-MIRGGVLFPGTDHIDQWNKII 236 E + YT + D+W+ G M E M RG + G ++ + +N +I Sbjct: 208 LESLADNLYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLI 253 >5FQD-C nrPDB Length = 341 Score = 52.0 bits (123), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 46/161 (28%), Positives = 78/161 (48%), Gaps = 15/161 (9%) Query: 18 FTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKL 77 F + +Y +R IGSG+ G + A + + VA+K S Q H + Y E KL K+ Sbjct: 15 FIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLES---QKARHPQLLY-ESKLYKI 70 Query: 78 VNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLY---QML 134 + I + + +++ LVM+L+ +L + M +L QM+ Sbjct: 71 LQGGVGIPHIRWYGQEKDYN-----VLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMI 125 Query: 135 CGIKHLHSAGIIHRDLKPSNIV--VKADCT-LKILDFGLAR 172 I+++H+ IHRD+KP N + + C L ++DFGLA+ Sbjct: 126 SRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAK 166 >4XHL-A nrPDB Length = 394 Score = 52.0 bits (123), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 56/230 (24%), Positives = 106/230 (46%), Gaps = 30/230 (13%) Query: 28 RPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLL 87 R IGSG+ G + + I+ + VAI+ S H + Y E ++ + ++ I + Sbjct: 13 RKIGSGSFGDIYHGTNLISGEEVAIRLES---IRSRHPQLDY-ESRVYRYLSGGVGIPFI 68 Query: 88 NAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSY-----LLYQMLCGIKHLHS 142 F E + +V++L+ +L + + H R S+ L QM C I+++H Sbjct: 69 RWFG-----REGEYNAMVIDLLGPSLEDLF--NYCHRRFSFKTVIMLALQMFCRIQYIHG 121 Query: 143 AGIIHRDLKPSNIVV---KADCTLKILDFGLARTAG--TTFMMTPY------VVTRYYRA 191 IHRD+KP N ++ + T+ ++DFGL++ T PY T Y + Sbjct: 122 RSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTARYAS 181 Query: 192 PEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPG---TDHIDQWNKIIEQ 238 LG+ + D+ S+G ++ +G + + G T ++++I+E+ Sbjct: 182 VNTHLGIEQSRRDDLESLGYVLIYFCKGSLPWQGLKATTKKQKYDRIMEK 231 >2QKW-B nrPDB Length = 321 Score = 52.0 bits (123), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 46/153 (30%), Positives = 76/153 (49%), Gaps = 16/153 (10%) Query: 75 MKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQ-VIQMDLDHDRMSYLLYQM 133 + H +++ L+ F +RN E +Y ME + NL + + DL MS+ Sbjct: 89 LSFCRHPHLVSLI-GFCDERN--EMILIYKYME--NGNLKRHLYGSDLPTMSMSWEQRLE 143 Query: 134 LC-----GIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGT----TFMMTPYV 184 +C G+ +LH+ IIHRD+K NI++ + KI DFG+++ GT T + T Sbjct: 144 ICIGAARGLHYLHTRAIIHRDVKSINILLDENFVPKITDFGISKK-GTELDQTHLSTVVK 202 Query: 185 VTRYYRAPEVILGMGYTENVDIWSVGCIMGEMI 217 T Y PE + TE D++S G ++ E++ Sbjct: 203 GTLGYIDPEYFIKGRLTEKSDVYSFGVVLFEVL 235 >5FM2-A nrPDB Length = 355 Score = 52.0 bits (123), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 33/102 (32%), Positives = 51/102 (50%), Gaps = 10/102 (9%) Query: 131 YQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYR 190 +Q+ G+++L ++HRDL NI+V +KI DFGL+R + YV R Sbjct: 198 WQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSR---DVYEEDSYVKRSQGR 254 Query: 191 AP------EVILGMGYTENVDIWSVGCIMGEMIR-GGVLFPG 225 P E + YT D+WS G ++ E++ GG +PG Sbjct: 255 IPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPG 296 >5C26-A nrPDB Length = 299 Score = 52.0 bits (123), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 44/153 (28%), Positives = 68/153 (44%), Gaps = 20/153 (13%) Query: 129 LLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLART--------AGTTFMM 180 L++Q+ G+K+L + +HRDL N+++ KI DFGL++ T Sbjct: 132 LVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGK 191 Query: 181 TPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVL----FPGTDHIDQWNKII 236 P ++Y APE I ++ D+WS G +M E G G++ K Sbjct: 192 WP---VKWY-APECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEK-G 246 Query: 237 EQLGTPS--PSFMQRLQPTVRNY-VENRPRYTG 266 E++G P+ P M L Y VENRP + Sbjct: 247 ERMGCPAGCPREMYDLMNLCWTYDVENRPGFAA 279 >3LZB-A nrPDB Length = 327 Score = 52.0 bits (123), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 55/210 (26%), Positives = 88/210 (41%), Gaps = 17/210 (8%) Query: 21 HSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAK---RAYREFKLMKL 77 + + ++ +GSGA G V + V I + + T K E +M Sbjct: 14 ETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMAS 73 Query: 78 VNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQMDLDHDRMSYLL---YQM 133 V++ ++ LL V L+ +LM L ++ D+ YLL Q+ Sbjct: 74 VDNPHVCRLLGICLTS-------TVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQI 126 Query: 134 LCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGT---TFMMTPYVVTRYYR 190 G+ +L ++HRDL N++VK +KI DFGLA+ G + V + Sbjct: 127 AKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWM 186 Query: 191 APEVILGMGYTENVDIWSVGCIMGEMIRGG 220 A E IL YT D+WS G + E++ G Sbjct: 187 ALESILHRIYTHQSDVWSYGVTVWELMTFG 216 >5U6B-A nrPDB Length = 307 Score = 52.0 bits (123), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 56/234 (23%), Positives = 96/234 (41%), Gaps = 31/234 (13%) Query: 28 RPIGSGAQGIVCAAY----DTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNI 83 + +G G G V D+I + VA+K + + + E MK +H N+ Sbjct: 29 KTLGEGEFGAVMEGQLNQDDSILK--VAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNV 86 Query: 84 IGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQMDLDHDRMSYLLYQML-------- 134 + L+ E F +++ M +L + D+ YL QML Sbjct: 87 MRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIA 146 Query: 135 CGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAP-- 192 G+++L + IHRDL N ++ + ++ + DFGL++ + Y R + P Sbjct: 147 SGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSK---KIYNGDYYRQGRIAKMPVK 203 Query: 193 ----EVILGMGYTENVDIWSVGCIMGEM-IRGGVLFPGT------DHIDQWNKI 235 E + YT D+WS G M E+ RG +PG D++ Q N++ Sbjct: 204 WIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRL 257 >3M42-A nrPDB Length = 299 Score = 52.0 bits (123), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 69/314 (21%), Positives = 119/314 (37%), Gaps = 76/314 (24%) Query: 17 NFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKL-M 75 N I + + +G G G V ++ TQ+ A+K L +A RE +L Sbjct: 13 NAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ-------DCPKARREVELHW 65 Query: 76 KLVNHKNIIGLLNAFTPQRNLEEFQDVYL-VMELMDAN-LCQVIQMDLDHD----RMSYL 129 + +I+ +++ + NL + L VME +D L IQ D S + Sbjct: 66 RASQCPHIVRIVDVY---ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEI 122 Query: 130 LYQMLCGIKHLHSAGIIHRDLKPSNIVV---KADCTLKILDFGLARTAGTTFMMTPYVVT 186 + + I++LHS I HRD+KP N++ + + LK+ DFG A+ Sbjct: 123 MKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKET------------ 170 Query: 187 RYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSF 246 G Y ++ D+WS+G IM ++ G P F Sbjct: 171 ---------TGEKYDKSCDMWSLGVIMYILLCG-----------------------YPPF 198 Query: 247 MQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPE 306 + ++ R R Y F N + + + L+ +L +P Sbjct: 199 YSNHGLAISPGMKTRIRMGQYEFP------------NPEWSEVSEEVKMLIRNLLKTEPT 246 Query: 307 QRISVDEALKHEYI 320 QR+++ E + H +I Sbjct: 247 QRMTITEFMNHPWI 260 >6FER-A nrPDB Length = 309 Score = 52.0 bits (123), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 28/99 (28%), Positives = 52/99 (52%), Gaps = 5/99 (5%) Query: 121 LDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLART--AGTTF 178 + + + ++ Q+ G+K+L S +HRDL N +V + T+KI DFG++R +G + Sbjct: 130 VSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYY 189 Query: 179 MMTPYVV--TRYYRAPEVILGMGYTENVDIWSVGCIMGE 215 + V R+ ++LG +T D+W+ G + E Sbjct: 190 RIQGRAVLPIRWMSWESILLG-KFTTASDVWAFGVTLWE 227 >5AMN-A nrPDB Length = 299 Score = 51.6 bits (122), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 46/169 (27%), Positives = 74/169 (43%), Gaps = 17/169 (10%) Query: 71 EFKLMKLVNHKNIIGLLNAFT---PQRNLEEFQDVY----LVMELMDANLCQVIQMDLDH 123 EF ++K VNH ++I L A + P + E+ + E + L Sbjct: 76 EFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYPDERALTM 135 Query: 124 DRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPY 183 + +Q+ G+++L ++HRDL NI+V +KI DFGL+R + Y Sbjct: 136 GDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSR---DVYEEDSY 192 Query: 184 VVTRYYRAP------EVILGMGYTENVDIWSVGCIMGEMIR-GGVLFPG 225 V R P E + YT D+WS G ++ E++ GG +PG Sbjct: 193 VKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPG 241 >4FL3-A nrPDB Length = 635 Score = 50.8 bits (120), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 51/186 (27%), Positives = 83/186 (44%), Gaps = 23/186 (12%) Query: 98 EFQDVYLVMELMD-ANLCQVIQMD--LDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSN 154 E + LVME+ + L + +Q + + + L++Q+ G+K+L + +HRDL N Sbjct: 440 EAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARN 499 Query: 155 IVVKADCTLKILDFGLART--------AGTTFMMTPYVVTRYYRAPEVILGMGYTENVDI 206 +++ KI DFGL++ T P ++Y APE I ++ D+ Sbjct: 500 VLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWP---VKWY-APECINYYKFSSKSDV 555 Query: 207 WSVGCIMGEMIRGGVL----FPGTDHIDQWNKIIEQLGTPS--PSFMQRLQPTVRNY-VE 259 WS G +M E G G++ K E++G P+ P M L Y VE Sbjct: 556 WSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEK-GERMGCPAGCPREMYDLMNLCWTYDVE 614 Query: 260 NRPRYT 265 NRP + Sbjct: 615 NRPGFA 620 >3MDY-A nrPDB Length = 337 Score = 50.8 bits (120), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 64/231 (27%), Positives = 104/231 (45%), Gaps = 36/231 (15%) Query: 19 TIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMK-- 76 TI + ++ IG G G V + VA+K T +RE ++ + Sbjct: 34 TIAKQIQMVKQIGKGRYGEVWMG--KWRGEKVAVKVFF-----TTEEASWFRETEIYQTV 86 Query: 77 LVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQ-MDLDHDRMSYLLYQML 134 L+ H+NI+G + A + + +YL+ + + +L ++ LD M L Y + Sbjct: 87 LMRHENILGFIAADI--KGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSV 144 Query: 135 CGIKHLHS--------AGIIHRDLKPSNIVVKADCTLKILDFGLART--AGTTFMMTP-- 182 G+ HLH+ I HRDLK NI+VK + T I D GLA + T + P Sbjct: 145 SGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPN 204 Query: 183 -YVVTRYYRAPEVI---LGMGYTEN---VDIWSVGCIMGEMIR----GGVL 222 V T+ Y PEV+ L + ++ D++S G I+ E+ R GG++ Sbjct: 205 TRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIV 255 >5X1R-A nrPDB Length = 302 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 53/221 (23%), Positives = 89/221 (40%), Gaps = 41/221 (18%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKK-----LSRPFQNVTHAKRAYR-------------- 70 IG G GIV AYD ++ +AIK+ L++ +++ R R Sbjct: 29 IGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAKRNDDLSIGLRGERFGKTFQAGLNSFIQ 88 Query: 71 EFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMD----LDHDRM 126 E +L+ +H ++ +L R EE Y+ + + +Q +D + Sbjct: 89 EARLLARFSHPGLLHVL------RFWEENGTAYMGTQFYSGTTLKNLQAQQPEKIDEAWI 142 Query: 127 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVT 186 LL + I +H G +HRD+ NI ++ +LDFG AR +V Sbjct: 143 RRLLPPLFSAINTIHQEGYLHRDISLDNIQIQESQLPVLLDFGSARKEIGNLSDETEIVL 202 Query: 187 RYYRAPEVILGMGYTEN--------VDIWSVGCIMGEMIRG 219 + AP YTEN DI+++G ++ +I G Sbjct: 203 KPGFAPI----EQYTENSDGEQGPWTDIYALGAVLHTLIVG 239 >4XHH-A nrPDB Length = 403 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 55/230 (23%), Positives = 107/230 (46%), Gaps = 30/230 (13%) Query: 28 RPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLL 87 R IGSG+ G + + I+ + VAI+ S H + Y E ++ K ++ I + Sbjct: 13 RKIGSGSFGDIYHGTNLISGEEVAIRLES---IRSRHPQLDY-ESRVYKYLSGGVGIPFI 68 Query: 88 NAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSY-----LLYQMLCGIKHLHS 142 F E + +V++L+ +L + + H + S+ L QM+C ++++H Sbjct: 69 RWFG-----REGEYNAMVIDLLGPSLEDLF--NYCHRKFSFKTVIMLALQMICRVQYIHG 121 Query: 143 AGIIHRDLKPSNIVV---KADCTLKILDFGLARTAG--TTFMMTPY------VVTRYYRA 191 IHRD+KP N ++ + T+ ++DFGL++ T PY T Y + Sbjct: 122 RSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTARYAS 181 Query: 192 PEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPG---TDHIDQWNKIIEQ 238 LG+ + D+ S+G ++ +G + + G T ++++I+E+ Sbjct: 182 VNTHLGIEQSRRDDLESLGYMLIYFCKGSLPWQGLKATTKKQKYDRILEK 231 >5KMM-A nrPDB Length = 329 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 58/227 (25%), Positives = 95/227 (41%), Gaps = 54/227 (23%) Query: 30 IGSGAQGIVCAA--YDTITQQN---VAIKKLSRPFQNVTHAKRAY-REFKLMKLVNHKNI 83 +G GA G V A ++ + +Q+ VA+K L ++ A++ + RE +L+ ++ H++I Sbjct: 43 LGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASES---ARQDFQREAELLTMLQHQHI 99 Query: 84 IGLLNAFTPQRNLEEFQDVYLVMELM--------------DANLCQ----VIQMDLDHDR 125 + T R L +V E M DA L V L + Sbjct: 100 VRFFGVCTEGRPL------LMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQ 153 Query: 126 MSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVV 185 + + Q+ G+ +L +HRDL N +V +KI DFG++R + Sbjct: 154 LLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYS--------- 204 Query: 186 TRYYRA------------PEVILGMGYTENVDIWSVGCIMGEMIRGG 220 T YYR PE IL +T D+WS G ++ E+ G Sbjct: 205 TDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYG 251 >5IKW-A nrPDB Length = 310 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 53/170 (31%), Positives = 75/170 (44%), Gaps = 33/170 (19%) Query: 70 REFKLMK-LVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVI-QMD--LDHDR 125 RE +MK L HKNI+G L+ + + +V ++ME A QV+ QM+ L Sbjct: 59 REITIMKELSGHKNIVGYLDCAVNSIS-DNVWEVLILMEYCRAG--QVVNQMNKKLQTGF 115 Query: 126 MSYLLYQMLC----GIKHLHSAG--IIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFM 179 + Q+ C + LH IIHRDLK NI++ + DFG A T Sbjct: 116 TEPEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSA----TNKF 171 Query: 180 MTPY-------------VVTRYYRAPEVI---LGMGYTENVDIWSVGCIM 213 + P T YRAPE+I G T DIW++GC++ Sbjct: 172 LNPQKDGVNVVEEEIKKYTTLSYRAPEMINLYGGKPITTKADIWALGCLL 221 >1PY5-A nrPDB Length = 326 Score = 50.1 bits (118), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 58/225 (25%), Positives = 104/225 (46%), Gaps = 48/225 (21%) Query: 69 YREFKLMK--LVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVI-QMDLDHD 124 +RE ++ + ++ H+NI+G + A ++ + ++LV + + +L + + + + Sbjct: 69 FREAEIYQTVMLRHENILGFIAA--DNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVE 126 Query: 125 RMSYLLYQMLCGIKHLH--------SAGIIHRDLKPSNIVVKADCTLKILDFGLA---RT 173 M L G+ HLH I HRDLK NI+VK + T I D GLA + Sbjct: 127 GMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDS 186 Query: 174 AGTTFMMTP--YVVTRYYRAPEVI---LGMGYTEN---VDIWSVGCIMGEMIR----GGV 221 A T + P V T+ Y APEV+ + M + E+ DI+++G + E+ R GG+ Sbjct: 187 ATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGI 246 Query: 222 ----------LFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRN 256 L P +++ K++ + Q+L+P + N Sbjct: 247 HEDYQLPYYDLVPSDPSVEEMRKVVCE---------QKLRPNIPN 282 >4OLI-A nrPDB Length = 645 Score = 50.1 bits (118), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 56/212 (26%), Positives = 91/212 (42%), Gaps = 22/212 (10%) Query: 20 IHSRYIN-LRPIGSGAQGIVCA-AYDTI---TQQNVAIKKLSRPFQNVTHAKRAYREFKL 74 H RY+ +R +G G G V YD T + VA+K L + H +E + Sbjct: 350 FHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKAL-KADCGPQHRSGWKQEIDI 408 Query: 75 MKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQMDLDHDRMSYLLYQM 133 ++ + H++II Q + + LVME + +L + L Q Sbjct: 409 LRTLYHEHIIKYKGCCEDQGE----KSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQ 464 Query: 134 LC-GIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTR----- 187 +C G+ +LHS IHR+L N+++ D +KI DFGLA+ Y R Sbjct: 465 ICEGMAYLHSQHYIHRNLAARNVLLDNDRLVKIGDFGLAKAVPEGHE---YYRVREDGDS 521 Query: 188 --YYRAPEVILGMGYTENVDIWSVGCIMGEMI 217 ++ APE + + D+WS G + E++ Sbjct: 522 PVFWYAPECLKEYKFYYASDVWSFGVTLYELL 553 >6DBM-A nrPDB Length = 318 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 56/226 (24%), Positives = 94/226 (41%), Gaps = 48/226 (21%) Query: 19 TIHSRYIN-LRPIGSGAQGIVCA-AYDTI---TQQNVAIKKLSRPFQNVTHAKRAYREFK 73 H RY+ +R +G G G V YD T + VA+K L + H +E Sbjct: 27 VFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKAL-KADAGPQHRSGWKQEID 85 Query: 74 LMKLVNHKNIIG--------------LLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQM 119 +++ + H++II L+ + P +L ++ + + L Q++ Sbjct: 86 ILRTLYHEHIIKYKGCCEDAGAASLQLVMEYVPLGSLRDYLPRHSI------GLAQLL-- 137 Query: 120 DLDHDRMSYLLYQMLC-GIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTF 178 L Q +C G+ +LHS IHRDL N+++ D +KI DFGLA+ Sbjct: 138 ---------LFAQQICEGMAYLHSQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGH 188 Query: 179 MMTPYVVTR-------YYRAPEVILGMGYTENVDIWSVGCIMGEMI 217 Y R ++ APE + + D+WS G + E++ Sbjct: 189 ---EYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELL 231 >4CI6-B nrPDB Length = 643 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 29/96 (30%), Positives = 51/96 (53%), Gaps = 6/96 (6%) Query: 126 MSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVV-KADCTLKILDFGLARTAGTTFMMTPYV 184 + ++ +++L HL AGI+H D+KP N+V +A ++D GL +G P Sbjct: 158 IKFIAHRLLDVTNHLAKAGIVHNDIKPGNVVFDRASGEPVVIDLGLHSRSGE----QPKG 213 Query: 185 VTRYYRAPEVILG-MGYTENVDIWSVGCIMGEMIRG 219 T ++APE+ +G +G +E D++ V + I G Sbjct: 214 FTESFKAPELGVGNLGASEKSDVFLVVSTLLHGIEG 249 >1U59-A nrPDB Length = 287 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 55/222 (24%), Positives = 94/222 (42%), Gaps = 39/222 (17%) Query: 11 VEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQ-NVAIKKLSRPFQNVTHAKRAY 69 +E+G NF GS QG+ Y +Q +VAIK L + + + Sbjct: 16 IELGCGNF------------GSVRQGV----YRMRKKQIDVAIKVLKQGTEK-ADTEEMM 58 Query: 70 REFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVI----QMDLDHDR 125 RE ++M +++ I+ L+ + + + LVME+ + ++ Sbjct: 59 REAQIMHQLDNPYIVRLIGVC-------QAEALMLVMEMAGGGPLHKFLVGKREEIPVSN 111 Query: 126 MSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVV 185 ++ LL+Q+ G+K+L +HRDL N+++ KI DFGL++ G Y Sbjct: 112 VAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGAD---DSYYT 168 Query: 186 TRY-------YRAPEVILGMGYTENVDIWSVGCIMGEMIRGG 220 R + APE I ++ D+WS G M E + G Sbjct: 169 ARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYG 210 >4LRM-A nrPDB Length = 334 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 40/126 (31%), Positives = 60/126 (47%), Gaps = 7/126 (5%) Query: 102 VYLVMELMD-ANLCQVIQMDLDHDRMSYLL---YQMLCGIKHLHSAGIIHRDLKPSNIVV 157 V L+ +LM L ++ D+ YLL Q+ G+ +L ++HRDL N++V Sbjct: 98 VQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLV 157 Query: 158 KADCTLKILDFGLARTAGT---TFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMG 214 K +KI DFGLA+ G + V + A E IL YT D+WS G + Sbjct: 158 KTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVW 217 Query: 215 EMIRGG 220 E++ G Sbjct: 218 ELMTFG 223 >4E20-A nrPDB Length = 290 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 55/213 (25%), Positives = 90/213 (42%), Gaps = 22/213 (10%) Query: 19 TIHSRYIN-LRPIGSGAQGIVCA-AYDTI---TQQNVAIKKLSRPFQNVTHAKRAYREFK 73 H RY+ +R +G G G V YD T + VA+K L + RE + Sbjct: 4 VFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSGWQ-REIE 62 Query: 74 LMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQMDLDHDRMSYLLYQ 132 +++ + H++I+ Q + V LVME + +L + L Q Sbjct: 63 ILRTLYHEHIVKYKGCCEDQGE----KSVQLVMEYVPLGSLRDYLPRHCVGLAQLLLFAQ 118 Query: 133 MLC-GIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTR---- 187 +C G+ +LH+ IHR L N+++ D +KI DFGLA+ Y R Sbjct: 119 QICEGMAYLHAQHYIHRALAARNVLLDNDRLVKIGDFGLAKAVPEGH---EYYRVREDGD 175 Query: 188 ---YYRAPEVILGMGYTENVDIWSVGCIMGEMI 217 ++ APE + + D+WS G + E++ Sbjct: 176 SPVFWYAPECLKECKFYYASDVWSFGVTLYELL 208 >6FEX-A nrPDB Length = 321 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 46/181 (25%), Positives = 79/181 (43%), Gaps = 14/181 (7%) Query: 50 VAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDV------- 102 VA+K L RP +E K+M + NII LL L D Sbjct: 60 VAVKIL-RPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLN 118 Query: 103 -YLVMELMDANLCQVIQMD--LDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKA 159 +L ++ + D + + + ++ Q+ G+++L + +HRDL N +V Sbjct: 119 QFLSAHQLEDKAAEGAPGDPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGE 178 Query: 160 DCTLKILDFGLART--AGTTFMMTPYVVTRY-YRAPEVILGMGYTENVDIWSVGCIMGEM 216 + T+KI DFG++R AG + + V + A E IL +T D+W+ G + E+ Sbjct: 179 NFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEV 238 Query: 217 I 217 + Sbjct: 239 L 239 >3SV0-A nrPDB Length = 483 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 64/247 (25%), Positives = 107/247 (43%), Gaps = 34/247 (13%) Query: 28 RPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLL 87 R IGSG+ G + + T + VAIK +NV + K +L+ I +L Sbjct: 13 RKIGSGSFGEIYLGTNIQTNEEVAIK-----LENV--------KTKHPQLLYESKIYRIL 59 Query: 88 NAFTPQRNLEEF--QDVY--LVMELMDANLCQVIQM---DLDHDRMSYLLYQMLCGIKHL 140 T N+ F + Y LVM+L+ +L + L + L QM+ ++ + Sbjct: 60 QGGTGIPNVRWFGVEGDYNVLVMDLLGPSLEDLFNFCSRKLSLKTVLMLADQMINRVEFV 119 Query: 141 HSAGIIHRDLKPSNIVV---KADCTLKILDFGLART--AGTTFMMTPY------VVTRYY 189 HS +HRD+KP N ++ + + I+DFGLA+ +T PY T Y Sbjct: 120 HSKSFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDTSTHQHIPYRENKNLTGTARY 179 Query: 190 RAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTD---HIDQWNKIIEQLGTPSPSF 246 + LG+ + D+ S+G ++ +RG + + G ++ KI E+ S Sbjct: 180 ASVNTHLGIEQSRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKYEKISEKKVATSIEA 239 Query: 247 MQRLQPT 253 + R PT Sbjct: 240 LCRGYPT 246 >2OZO-A nrPDB Length = 613 Score = 49.3 bits (116), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 54/220 (24%), Positives = 95/220 (43%), Gaps = 35/220 (15%) Query: 11 VEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQ-NVAIKKLSRPFQNVTHAKRAY 69 +E+G NF GS QG+ Y +Q +VAIK L + + + Sbjct: 342 IELGCGNF------------GSVRQGV----YRMRKKQIDVAIKVLKQGTEKAD-TEEMM 384 Query: 70 REFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVI----QMDLDHDR 125 RE ++M +++ I+ L+ + + + LVME+ + ++ Sbjct: 385 REAQIMHQLDNPYIVRLIGVC-------QAEALMLVMEMAGGGPLHKFLVGKREEIPVSN 437 Query: 126 MSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGT-----TFMM 180 ++ LL+Q+ G+K+L +HR+L N+++ KI DFGL++ G T Sbjct: 438 VAELLHQVSMGMKYLEEKNFVHRNLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARS 497 Query: 181 TPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGG 220 ++Y APE I ++ D+WS G M E + G Sbjct: 498 AGKWPLKWY-APECINFRKFSSRSDVWSYGVTMWEALSYG 536 >3PP0-A nrPDB Length = 338 Score = 48.9 bits (115), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 31/92 (33%), Positives = 47/92 (51%), Gaps = 3/92 (3%) Query: 132 QMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAG---TTFMMTPYVVTRY 188 Q+ G+ +L ++HRDL N++VK+ +KI DFGLAR T + V Sbjct: 127 QIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIK 186 Query: 189 YRAPEVILGMGYTENVDIWSVGCIMGEMIRGG 220 + A E IL +T D+WS G + E++ G Sbjct: 187 WMALESILRRRFTHQSDVWSYGVTVWELMTFG 218 >6BSD-A nrPDB Length = 876 Score = 48.9 bits (115), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 48/187 (25%), Positives = 77/187 (41%), Gaps = 20/187 (10%) Query: 50 VAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDV------- 102 VA+K L RP +E K+M + NII LL L D Sbjct: 615 VAVKIL-RPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLN 673 Query: 103 -YLVMELMDANLCQVIQMDLDHDRMSYLLYQML--------CGIKHLHSAGIIHRDLKPS 153 +L ++ + D + + Y ML G+++L + +HRDL Sbjct: 674 QFLSAHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATR 733 Query: 154 NIVVKADCTLKILDFGLART--AGTTFMMTPYVVTRY-YRAPEVILGMGYTENVDIWSVG 210 N +V + T+KI DFG++R AG + + V + A E IL +T D+W+ G Sbjct: 734 NCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFG 793 Query: 211 CIMGEMI 217 + E++ Sbjct: 794 VTLWEVL 800 >5J0A-A nrPDB Length = 300 Score = 48.5 bits (114), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 53/197 (26%), Positives = 88/197 (44%), Gaps = 47/197 (23%) Query: 51 AIKKLSRPFQN----VTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVM 106 A+KK++ P N + KR E K++K ++H NI+G AFT Sbjct: 41 AVKKIN-PICNDHYRSVYQKRLMDEAKILKSLHHPNIVGY-RAFT--------------- 83 Query: 107 ELMDANLCQVIQM-------DLDHDR------------MSYLLYQMLCGIKHLH-SAGII 146 E D +LC ++ DL +R + + M G+K+LH ++ Sbjct: 84 EANDGSLCLAMEYGGEKSLNDLIEERYKASQDPFPAAIILKVALNMARGLKYLHQEKKLL 143 Query: 147 HRDLKPSNIVVKADC-TLKILDFGLARTAGTTFMMTP----YVVTRYYRAPEVILGMGY- 200 H D+K SN+V+K D T+KI D G++ +T Y+ T ++ E + G Sbjct: 144 HGDIKSSNVVIKGDFETIKICDVGVSLPLDENMEVTDPEACYIGTEPWKPKEAVEENGVI 203 Query: 201 TENVDIWSVGCIMGEMI 217 T+ DI++ G + EM+ Sbjct: 204 TDKADIFAFGLTLWEMM 220 >5OAT-A nrPDB Length = 411 Score = 48.5 bits (114), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 51/185 (27%), Positives = 76/185 (41%), Gaps = 28/185 (15%) Query: 77 LVNHKNIIGLLNAFT-------PQRNLEEFQ----DVYLVMELMDANLCQVIQMDLDHDR 125 L H NI+ + + FT P R E + ++L+M+ D NL + Sbjct: 95 LPPHPNIVAIFSVFTDLYPAALPPRLHPEGEGRNMSLFLLMKRYDCNLQSFLSTAPSTRT 154 Query: 126 MSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKA----DCTLKILDFGLARTAGTTFMMT 181 LL Q+L G+ H+ + GI HRDLK N+++ L I DFG T + Sbjct: 155 SLLLLAQLLEGVAHMTAHGIAHRDLKSDNLLLDTSEPESPILVISDFGCCLADKTNGLSL 214 Query: 182 PYVVTRYYR-------APEVILGMGYTENV------DIWSVGCIMGEMIRGGVLFPGTDH 228 PY + APE+I T +V D+W+VG I E+ F G Sbjct: 215 PYTSYEMDKGGNTALMAPEIICQKPGTFSVLNYSKADLWAVGAIAYEIFNCHNPFYGPSR 274 Query: 229 IDQWN 233 + +N Sbjct: 275 LKNFN 279 >4XLV-A nrPDB Length = 328 Score = 48.1 bits (113), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 56/224 (25%), Positives = 97/224 (43%), Gaps = 54/224 (24%) Query: 27 LRPIGSGAQGIVCA--AYDTI---TQQNVAIKKLSRPFQNVTHAKRAYREF----KLMKL 77 LR +G G+ G+V A D I + VA+K + N + + R EF +MK Sbjct: 44 LRELGQGSFGMVYEGNARDIIKGEAETRVAVKTV-----NESASLRERIEFLNEASVMKG 98 Query: 78 VNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMD----ANLCQVIQMDLDHD--------- 124 +++ LL + + Q +VMELM + + ++ + +++ Sbjct: 99 FTCHHVVRLLGVVS------KGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQ 152 Query: 125 RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYV 184 M + ++ G+ +L++ +HRDL N +V D T+KI DFG+ R Sbjct: 153 EMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRD---------IY 203 Query: 185 VTRYYR------------APEVILGMGYTENVDIWSVGCIMGEM 216 T YYR APE + +T + D+WS G ++ E+ Sbjct: 204 ETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEI 247 >4JRN-A nrPDB Length = 372 Score = 48.1 bits (113), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 50/228 (21%), Positives = 84/228 (36%), Gaps = 54/228 (23%) Query: 29 PIGSGAQGIVCAAYDTITQQNVAIKKL-------SRPFQNVTHAKRAYREFKLMKLVNHK 81 P+GSG V A D T + +A+K ++ YR F L K Sbjct: 75 PLGSGGFATVYEATDVETNEELAVKVFMSEKEPTDETMLDLQRESSCYRNFSLAKTAKDA 134 Query: 82 N-----------------------IIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQ 118 +IGL + P + +L+M +A++ +VI Sbjct: 135 QESCRFMVPSDVVMLEGQPASTEVVIGLTTRWVP--------NYFLLMMRAEADMSKVIS 186 Query: 119 MDLDHDRMS----------YLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDF 168 ++ YL Q + + ++ + GI+H D+KP+N ++ D L + DF Sbjct: 187 WVFGDASVNKSEFGLVVRMYLSSQAIKLVANVQAQGIVHTDIKPANFLLLKDGRLFLGDF 246 Query: 169 GLARTAGTTFMMTPYVVTRYYRAPE---VILGMGYTENVDIWSVGCIM 213 G R + + + T Y PE G+ YT D W +G + Sbjct: 247 GTYRINNS---VGRAIGTPGYEPPERPFQATGITYTFPTDAWQLGITL 291 >1LUF-A nrPDB Length = 343 Score = 47.8 bits (112), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 61/235 (25%), Positives = 91/235 (38%), Gaps = 52/235 (22%) Query: 27 LRPIGSGAQGIVCAA-------YDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVN 79 +R IG GA G V A Y+ T VA+K L A RE LM + Sbjct: 52 VRDIGEGAFGRVFQARAPGLLPYEPFTM--VAVKMLKEEASADMQADFQ-REAALMAEFD 108 Query: 80 HKNIIGLLNAFT---PQRNLEEFQDVYLVMELMDA----NLCQVIQMDLD-HDRMS---- 127 + NI+ LL P L E+ + E + + +C + DL R+S Sbjct: 109 NPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRARVSSPGP 168 Query: 128 ---------YLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTF 178 + Q+ G+ +L +HRDL N +V + +KI DFGL+R + Sbjct: 169 PPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYS-- 226 Query: 179 MMTPYVVTRYYRA------------PEVILGMGYTENVDIWSVGCIMGEMIRGGV 221 YY+A PE I YT D+W+ G ++ E+ G+ Sbjct: 227 -------ADYYKADGNDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGL 274 >2QLU-A nrPDB Length = 314 Score = 47.4 bits (111), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 52/203 (25%), Positives = 88/203 (43%), Gaps = 32/203 (15%) Query: 39 CAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLE- 97 C + VA+K P Q+ + ++ RE + H+N++ + A NLE Sbjct: 30 CVWKAQLMNDFVAVKIF--PLQD-KQSWQSEREIFSTPGMKHENLLQFIAAEKRGSNLEV 86 Query: 98 ------EFQDVYLVMELMDAN------LCQVIQMDLDHDRMSYLLYQMLCGIKHLHSAGI 145 F D + + + N LC V + +SYL + H I Sbjct: 87 ELWLITAFHDKGSLTDYLKGNIITWNELCHVAETM--SRGLSYLHEDVPWCRGEGHKPSI 144 Query: 146 IHRDLKPSNIVVKADCTLKILDFGLA------RTAGTTFMMTPYVVTRYYRAPEVILG-M 198 HRD K N+++K+D T + DFGLA + G T V TR Y APEV+ G + Sbjct: 145 AHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQ---VGTRRYMAPEVLEGAI 201 Query: 199 GYTEN----VDIWSVGCIMGEMI 217 + + +D++++G ++ E++ Sbjct: 202 NFQRDAFLRIDMYAMGLVLWELV 224 >3BBT-B nrPDB Length = 328 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 54/206 (26%), Positives = 90/206 (43%), Gaps = 21/206 (10%) Query: 27 LRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFK----LMKLVNHKN 82 ++ +GSGA G V + V I ++ N T +A EF +M ++H + Sbjct: 20 VKVLGSGAFGTVYKGIWVPEGETVKIP-VAIKILNETTGPKANVEFMDEALIMASMDHPH 78 Query: 83 IIGLLN-AFTPQRNLEEFQDVYLVMELMD-ANLCQVIQMDLDHDRMSYLL---YQMLCGI 137 ++ LL +P + LV +LM L + + D+ LL Q+ G+ Sbjct: 79 LVRLLGVCLSPT--------IQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGM 130 Query: 138 KHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTA---GTTFMMTPYVVTRYYRAPEV 194 +L ++HRDL N++VK+ +KI DFGLAR + + + A E Sbjct: 131 MYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALEC 190 Query: 195 ILGMGYTENVDIWSVGCIMGEMIRGG 220 I +T D+WS G + E++ G Sbjct: 191 IHYRKFTHQSDVWSYGVTIWELMTFG 216 >2VD5-A nrPDB Length = 412 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 48/180 (26%), Positives = 78/180 (43%), Gaps = 28/180 (15%) Query: 99 FQD---VYLVMEL-MDANLCQVIQM---DLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLK 151 FQD +YLVME + +L ++ + + + L +++ I +H G +HRD+K Sbjct: 130 FQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIK 189 Query: 152 PSNIVVKADCTLKILDFG--LARTAGTTFMMTPYVVTRYYRAPEVILGMGYTE------- 202 P NI++ +++ DFG L A T V T Y +PE++ +G Sbjct: 190 PDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGP 249 Query: 203 NVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKII---EQLGTP---------SPSFMQRL 250 D W++G EM G F + + KI+ E L P + F+QRL Sbjct: 250 ECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRL 309 >4HZS-A nrPDB Length = 341 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 53/224 (23%), Positives = 92/224 (41%), Gaps = 21/224 (9%) Query: 7 QHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVC-AAYDTITQQ--NVAIKKLSRPFQNVT 63 Q T +G+ + + L +G G+ G+V +D + + +VA+K L + Sbjct: 3 QSLTCLIGEKDLRL------LEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQP 56 Query: 64 HAKRAY-REFKLMKLVNHKNIIGLLNAF--TPQRNLEEFQDVYLVMELMDANLCQVIQMD 120 A + RE M ++H+N+I L P + + E + +++ + + + Sbjct: 57 EAMDDFIREVNAMHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGT 116 Query: 121 LDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTT--- 177 L S Q+ G+ +L S IHRDL N+++ +KI DFGL R Sbjct: 117 L-----SRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDH 171 Query: 178 -FMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGG 220 M V + APE + ++ D W G + EM G Sbjct: 172 YVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYG 215 >2PMN-X nrPDB Length = 348 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 61/254 (24%), Positives = 106/254 (41%), Gaps = 74/254 (29%) Query: 99 FQDVYLVMELMDANLCQVIQMD-----LDHDRMSYLLYQML-CGIK-------HLHS-AG 144 + +VY++ E M+ + +++ D LD + ++ Q++ C IK ++H+ Sbjct: 115 YDEVYIIYEYMEND--SILKFDEYFFVLDKNYTCFIPIQVIKCIIKSVLNSFSYIHNEKN 172 Query: 145 IIHRDLKPSNIVVKADCTLKILDFG---------LARTAGTTFMMTPYVVTRYYRAPEVI 195 I HRD+KPSNI++ + +K+ DFG + + GT M P ++ Sbjct: 173 ICHRDVKPSNILMDKNGRVKLSDFGESEYMVDKKIKGSRGTYEFMPP----EFFSNESSY 228 Query: 196 LGMGYTENVDIWSVGCIMGEMIRGGVLFP-GTDHIDQWNKIIEQLGTPSPSFMQRLQPTV 254 G VDIWS+G + M V F ++ +N I Sbjct: 229 NGAK----VDIWSLGICLYVMFYNVVPFSLKISLVELFNNI------------------- 265 Query: 255 RNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSK--------MLVIDPE 306 R + Y DR L+P N +K++ + N LS L +P Sbjct: 266 ------RTKNIEYPLDR--NHFLYPLTN-----KKSTCSNNFLSNEDIDFLKLFLRKNPA 312 Query: 307 QRISVDEALKHEYI 320 +RI+ ++ALKHE++ Sbjct: 313 ERITSEDALKHEWL 326 >3I81-A nrPDB Length = 315 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 54/234 (23%), Positives = 97/234 (41%), Gaps = 50/234 (21%) Query: 12 EVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYRE 71 EV T+ SR + G +G+ + VAIK + N + R E Sbjct: 14 EVAREKITM-SRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTV-----NEAASMRERIE 67 Query: 72 F----KLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMD----ANLCQVIQMDLDH 123 F +MK N +++ LL + + Q ++MELM + + ++ ++++ Sbjct: 68 FLNEASVMKEFNCHHVVRLLGVVS------QGQPTLVIMELMTRGDLKSYLRSLRPEMEN 121 Query: 124 D---------RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTA 174 + +M + ++ G+ +L++ +HRDL N +V D T+KI DFG+ R Sbjct: 122 NPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRD- 180 Query: 175 GTTFMMTPYVVTRYYR------------APEVILGMGYTENVDIWSVGCIMGEM 216 T YYR +PE + +T D+WS G ++ E+ Sbjct: 181 --------IYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEI 226 >1U54-B nrPDB Length = 291 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 53/224 (23%), Positives = 92/224 (41%), Gaps = 21/224 (9%) Query: 7 QHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVC-AAYDTITQQ--NVAIKKLSRPFQNVT 63 Q T +G+ + + L +G G+ G+V +D + + +VA+K L + Sbjct: 9 QSLTCLIGEKDLRL------LEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQP 62 Query: 64 HAKRAY-REFKLMKLVNHKNIIGLLNAF--TPQRNLEEFQDVYLVMELMDANLCQVIQMD 120 A + RE M ++H+N+I L P + + E + +++ + + + Sbjct: 63 EAMDDFIREVNAMHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGT 122 Query: 121 LDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTT--- 177 L S Q+ G+ +L S IHRDL N+++ +KI DFGL R Sbjct: 123 L-----SRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDH 177 Query: 178 -FMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGG 220 M V + APE + ++ D W G + EM G Sbjct: 178 YVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYG 221 >4LQP-A nrPDB Length = 508 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 37/152 (24%), Positives = 70/152 (46%), Gaps = 14/152 (9%) Query: 26 NLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIG 85 ++ IG GA G V T + A+K L + Y++ +L + ++++ Sbjct: 106 TVKVIGKGAFGEVRLVQKKDTGKIYAMKTLLK--------SEMYKKDQLAHVKAERDVLA 157 Query: 86 LLNAFTPQRNLEEFQD---VYLVMELMDAN--LCQVIQMDL-DHDRMSYLLYQMLCGIKH 139 ++ FQD +YL+ME + + +I+ L D + + + + I+ Sbjct: 158 GSDSPWVVSLYYSFQDAQYLYLIMEFLPGGDLMTMLIRWQLFTEDVTRFYMAECILAIET 217 Query: 140 LHSAGIIHRDLKPSNIVVKADCTLKILDFGLA 171 +H G IHR +KP NI++ +K+ DFGL+ Sbjct: 218 IHKLGFIHRAIKPDNILIDIRGHIKLSDFGLS 249 Score = 36.2 bits (82), Expect = 0.022, Method: Compositional matrix adjust. Identities = 21/59 (35%), Positives = 28/59 (47%) Query: 178 FMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKII 236 M V T Y APE+ L GY + D WS+G IM E + G F + + KI+ Sbjct: 318 LMAYSTVGTPDYIAPEIFLYQGYGQECDWWSLGAIMYECLIGWPPFCSETPQETYRKIM 376 >5XD6-A nrPDB Length = 305 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 28/90 (31%), Positives = 46/90 (51%), Gaps = 6/90 (6%) Query: 136 GIKHLHSAG---IIHRDLKPSNIVVKADCTLKILDFGLARTA---GTTFMMTPYVVTRYY 189 G+++LH +IHRD+K SN+++ D KI DF L+ A T + T Y Sbjct: 138 GLEYLHEKANPHVIHRDIKSSNVLLFDDDVAKIADFDLSNQAPDMAARLHSTRVLGTFGY 197 Query: 190 RAPEVILGMGYTENVDIWSVGCIMGEMIRG 219 APE + + D++S G ++ E++ G Sbjct: 198 HAPEYAMTGTLSTKSDVYSFGVVLLELLTG 227 >1CSN-A nrPDB Length = 298 Score = 45.1 bits (105), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 48/214 (22%), Positives = 93/214 (43%), Gaps = 25/214 (11%) Query: 28 RPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLL 87 R IG G+ G++ + + Q VAIK R + + YR +KL+ G+ Sbjct: 16 RRIGEGSFGVIFEGTNLLNNQQVAIKFEPRR-SDAPQLRDEYRTYKLLA-----GCTGIP 69 Query: 88 NAFTPQRNLEEFQDVYLVMELMDANLCQVIQM---DLDHDRMSYLLYQMLCGIKHLHSAG 144 N + + E +V LV++L+ +L ++ + ++ QML ++ +H Sbjct: 70 NVYYFGQ--EGLHNV-LVIDLLGPSLEDLLDLCGRKFSVKTVAMAAKQMLARVQSIHEKS 126 Query: 145 IIHRDLKPSNIVV-----KADCTLKILDFGLAR--TAGTTFMMTPY------VVTRYYRA 191 +++RD+KP N ++ K + ++DFG+ + T PY T Y + Sbjct: 127 LVYRDIKPDNFLIGRPNSKNANMIYVVDFGMVKFYRDPVTKQHIPYREKKNLSGTARYMS 186 Query: 192 PEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPG 225 LG + D+ ++G + +RG + + G Sbjct: 187 INTHLGREQSRRDDLEALGHVFMYFLRGSLPWQG 220 >4TN6-A nrPDB Length = 318 Score = 45.1 bits (105), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 56/209 (26%), Positives = 92/209 (44%), Gaps = 25/209 (11%) Query: 20 IHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNV-THAKRAYREFKLMKLV 78 + +RY R IGSG+ G + D + VAIK + V T + + E K+ K++ Sbjct: 5 VGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIK-----LECVKTKHPQLHIESKIYKMM 59 Query: 79 NHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLY---QMLC 135 G + T + E +VMEL+ +L + + +L QM+ Sbjct: 60 Q-----GGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMIS 114 Query: 136 GIKHLHSAGIIHRDLKPSNIVV---KADCTLKILDFGLARTA--GTTFMMTPY------V 184 I+++HS IHRD+KP N ++ K + I+DFGLA+ T PY Sbjct: 115 RIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLT 174 Query: 185 VTRYYRAPEVILGMGYTENVDIWSVGCIM 213 T Y + LG+ + D+ S+G ++ Sbjct: 175 GTARYASINTHLGIEQSRRDDLESLGYVL 203 >2PZI-A nrPDB Length = 681 Score = 44.7 bits (104), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 29/94 (30%), Positives = 56/94 (59%), Gaps = 8/94 (8%) Query: 124 DRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFG-LARTAGTTFMMTP 182 + ++YLL ++L + +LHS G+++ DLKP NI++ + LK++D G ++R ++ Sbjct: 183 EAIAYLL-EILPALSYLHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINSFGYLYG- 239 Query: 183 YVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEM 216 T ++APE++ G T DI++VG + + Sbjct: 240 ---TPGFQAPEIVR-TGPTVATDIYTVGRTLAAL 269 >5U6C-A nrPDB Length = 315 Score = 44.3 bits (103), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 28/108 (25%), Positives = 53/108 (49%), Gaps = 10/108 (9%) Query: 136 GIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAP--- 192 G+++L + +HRDL N +++ D T+ + DFGL++ + Y R + P Sbjct: 161 GMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSK---KIYSGDYYRQGRIAKMPVKW 217 Query: 193 ---EVILGMGYTENVDIWSVGCIMGEM-IRGGVLFPGTDHIDQWNKII 236 E + YT D+W+ G M E+ RG +PG + + ++ ++ Sbjct: 218 IAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLL 265 >4Y12-A nrPDB Length = 375 Score = 44.3 bits (103), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 29/88 (32%), Positives = 54/88 (61%), Gaps = 8/88 (9%) Query: 124 DRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFG-LARTAGTTFMMTP 182 + ++YLL ++L + +LHS G+++ DLKP NI++ + LK++D G ++R ++ Sbjct: 222 EAIAYLL-EILPALSYLHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINSFGYLYG- 278 Query: 183 YVVTRYYRAPEVILGMGYTENVDIWSVG 210 T ++APE++ G T DI++VG Sbjct: 279 ---TPGFQAPEIVR-TGPTVATDIYTVG 302 >4F9B-A nrPDB Length = 361 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 31/115 (26%), Positives = 47/115 (40%), Gaps = 31/115 (26%) Query: 136 GIKHLHSAGIIHRDLKPSNIVVKADC-TLKILDFGLARTAGTTFM--------------- 179 +K +H GI+HRD+KPSN + ++DFGLA+ T + Sbjct: 129 ALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERC 188 Query: 180 --------------MTPYVVTRYYRAPEVILGM-GYTENVDIWSVGCIMGEMIRG 219 + P T +RAPEV+ T +D+WS G I ++ G Sbjct: 189 SQNKCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSG 243 >5LPV-A nrPDB Length = 296 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 54/209 (25%), Positives = 88/209 (42%), Gaps = 34/209 (16%) Query: 30 IGSGAQGIVCAAYDTITQQN--VAIKKLSRPFQNVTHAKRAYREF----KLMKLVNHKNI 83 IGSG G V Y I + VAIKKL + + + REF + + + H+N+ Sbjct: 25 IGSGGFGDV---YKAILKDGSAVAIKKL------IHVSGQGDREFMAEMETIGKIKHRNL 75 Query: 84 IGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMD-------LDHDRMSYLLYQMLCG 136 + LL + + LV E M + + D L+ + G Sbjct: 76 VPLLG------YCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARG 129 Query: 137 IKHLH---SAGIIHRDLKPSNIVVKADCTLKILDFGLARTAG---TTFMMTPYVVTRYYR 190 + LH S IIHRD+K SN+++ + ++ DFG+AR T ++ T Y Sbjct: 130 LAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYV 189 Query: 191 APEVILGMGYTENVDIWSVGCIMGEMIRG 219 PE + D++S G ++ E++ G Sbjct: 190 PPEYYQSFRCSTKGDVYSYGVVLLELLTG 218 >5LPZ-A nrPDB Length = 332 Score = 43.5 bits (101), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 55/213 (25%), Positives = 93/213 (43%), Gaps = 42/213 (19%) Query: 30 IGSGAQGIVCAAYDTITQQN--VAIKKLSRPFQNVTHAKRAYREF----KLMKLVNHKNI 83 IGSG G V Y I + VAIKKL + + + REF + + + H+N+ Sbjct: 25 IGSGGFGDV---YKAILKDGSAVAIKKL------IHVSGQGDREFMAEMETIGKIKHRNL 75 Query: 84 IGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHD------RMSYLLYQMLC-- 135 + LL + + LV E M + D+ HD ++++ + + Sbjct: 76 VPLLG------YCKVGDERLLVYEFMKYGSLE----DVLHDPKKAGVKLNWSTRRKIAIG 125 Query: 136 ---GIKHLH---SAGIIHRDLKPSNIVVKADCTLKILDFGLARTAG---TTFMMTPYVVT 186 G+ LH S IIHRD+K SN+++ + ++ DFG+AR T ++ T Sbjct: 126 SARGLAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGT 185 Query: 187 RYYRAPEVILGMGYTENVDIWSVGCIMGEMIRG 219 Y PE + D++S G ++ E++ G Sbjct: 186 PGYVPPEYYQSFRCSTKGDVYSYGVVLLELLTG 218 >5CLR-A nrPDB Length = 451 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 17/33 (51%), Positives = 23/33 (69%) Query: 137 IKHLHSAGIIHRDLKPSNIVVKADCTLKILDFG 169 +K H G+IHRDLKP NI++ AD ++DFG Sbjct: 189 VKQFHELGLIHRDLKPGNIMLDADMQCHLVDFG 221 >5AR8-A nrPDB Length = 326 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 40/160 (25%), Positives = 79/160 (49%), Gaps = 17/160 (10%) Query: 23 RYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLS--RPFQNVTHAKRAYREFKLMKLVNH 80 + +LR + GA G V +A + VA+K L P + + K RE +++ Sbjct: 33 KLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLD-SERKDVLREAEILHKARF 91 Query: 81 KNIIGLLNAFTPQRNLEEFQDVYLVMELM-DANLCQVIQMDLDHDRMSY-----LLYQML 134 I+ +L N EF + V E M + +L +++ ++ +++ +L+++ Sbjct: 92 SYILPILGIC----NEPEFLGI--VTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIA 145 Query: 135 CGIKHLH--SAGIIHRDLKPSNIVVKADCTLKILDFGLAR 172 G+ +LH + ++H DLK NI++ + +KI DFGL++ Sbjct: 146 LGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSK 185 >4H1J-A nrPDB Length = 293 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 44/179 (24%), Positives = 85/179 (47%), Gaps = 16/179 (8%) Query: 49 NVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMEL 108 NVA+K + + + ++ E +MK ++H +I+ L+ E + +++MEL Sbjct: 54 NVAVKTCKKDC-TLDNKEKFMSEAVIMKNLDHPHIVKLIGII-------EEEPTWIIMEL 105 Query: 109 MD-ANLCQVIQMDLDHDR-MSYLLYQM-LC-GIKHLHSAGIIHRDLKPSNIVVKADCTLK 164 L ++ + + + ++ +LY + +C + +L S +HRD+ NI+V + +K Sbjct: 106 YPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINCVHRDIAVRNILVASPECVK 165 Query: 165 ILDFGLARTAGTTFMMTPYVVTRY---YRAPEVILGMGYTENVDIWSVGCIMGEMIRGG 220 + DFGL+R VTR + +PE I +T D+W M E++ G Sbjct: 166 LGDFGLSRYIEDEDYYKA-SVTRLPIKWMSPESINFRRFTTASDVWMFAVCMWEILSFG 223 >4F0G-A nrPDB Length = 287 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 62/249 (24%), Positives = 105/249 (42%), Gaps = 30/249 (12%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKL-----SRPFQNVTHAKRAYREFKLMKLVNHKNII 84 IG G G+V + VAIK L + + + RE +M +NH NI+ Sbjct: 27 IGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQREVFIMSNLNHPNIV 86 Query: 85 GLLNAF-TPQRNLEEF---QDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGIKHL 140 L P R + EF D+Y L+D + L L+ + GI+++ Sbjct: 87 KLYGLMHNPPRMVMEFVPCGDLY--HRLLDKAHPIKWSVKLR------LMLDIALGIEYM 138 Query: 141 HSAG--IIHRDLKPSNIVVK-----ADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPE 193 + I+HRDL+ NI ++ A K+ DFGL++ + ++ + + APE Sbjct: 139 QNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQ--SVHSVSGLLGNFQWMAPE 196 Query: 194 VILG--MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHID-QWNKIIEQLGTPSPSFMQRL 250 I YTE D +S I+ ++ G F + ++ +I + G P+ + Sbjct: 197 TIGAEEESYTEKADTYSFAMILYTILTGEGPFDEYSYGKIKFINMIREEGL-RPTIPEDC 255 Query: 251 QPTVRNYVE 259 P +RN +E Sbjct: 256 PPRLRNVIE 264 >2WTK-B nrPDB Length = 373 Score = 42.4 bits (98), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 41/169 (24%), Positives = 68/169 (40%), Gaps = 23/169 (13%) Query: 71 EFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN-----LCQVIQMDLDHDR 125 E + KL NH NI+ F L ++V M +C ++ Sbjct: 60 ELHVSKLFNHPNIVPYRATFIADNEL------WVVTSFMAYGSAKDLICTHFMDGMNELA 113 Query: 126 MSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKAD---------CTLKILDFGLARTAGT 176 ++Y+L +L + ++H G +HR +K S+I++ D L ++ G + Sbjct: 114 IAYILQGVLKALDYIHHMGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVH 173 Query: 177 TFMMTPYVVTRYYRAPEVILG--MGYTENVDIWSVGCIMGEMIRGGVLF 223 F V + +PEV+ GY DI+SVG E+ G V F Sbjct: 174 DFPKYSVKVLPWL-SPEVLQQNLQGYDAKSDIYSVGITACELANGHVPF 221 >3UIM-A nrPDB Length = 326 Score = 42.4 bits (98), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 29/93 (31%), Positives = 47/93 (50%), Gaps = 5/93 (5%) Query: 136 GIKHLHS---AGIIHRDLKPSNIVVKADCTLKILDFGLARTA--GTTFMMTPYVVTRYYR 190 G+ +LH IIHRD+K +NI++ + + DFGLA+ T + T T + Sbjct: 143 GLAYLHDHCDPKIIHRDVKAANILLDEEFEAVVGDFGLAKLMDYKDTHVTTAVRGTIGHI 202 Query: 191 APEVILGMGYTENVDIWSVGCIMGEMIRGGVLF 223 APE + +E D++ G ++ E+I G F Sbjct: 203 APEYLSTGKSSEKTDVFGYGVMLLELITGQRAF 235 >5WNL-A nrPDB Length = 342 Score = 42.0 bits (97), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 48/182 (26%), Positives = 77/182 (42%), Gaps = 20/182 (10%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRA--YREFKLMKLVNHK 81 + +GSG G V + +AIK P +V +R E K M++ + Sbjct: 22 FAGWEKVGSGGFGQVYKVRHVHWKTWLAIK--CSPSLHVDDRERMELLEEAKKMEMAKFR 79 Query: 82 NIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMD--LDHDRMSYLLYQMLCGIKH 139 I+ + + V LVME M+ + + L D ++++ G+ Sbjct: 80 YILPVYGICQ--------EPVGLVMEYMETGSLEKLLASEPLPWDLRFRIVHETAVGMNF 131 Query: 140 LH--SAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTT----FMMTPYVVTRYYRAPE 193 LH S ++H +LKP+NI++ A +KI DFGLA+ G + M T Y PE Sbjct: 132 LHCMSPPLLHLNLKPANILLDAHYHVKISDFGLAKCNGMSHSHDLSMDGLFGTIAYLPPE 191 Query: 194 VI 195 I Sbjct: 192 RI 193 >5VC6-A nrPDB Length = 289 Score = 41.6 bits (96), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 36/147 (24%), Positives = 65/147 (44%), Gaps = 10/147 (6%) Query: 19 TIHSRYIN----LRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYRE-FK 73 ++ SRY L IGSG G V + AIK+ +P + A RE + Sbjct: 4 SMKSRYTTEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYA 63 Query: 74 LMKLVNHKNIIGLLNAFTPQRNL---EEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLL 130 L H +++ +A+ ++ E+ + + + + N I + LL Sbjct: 64 HAVLGQHSHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENY--RIMSYFKEAELKDLL 121 Query: 131 YQMLCGIKHLHSAGIIHRDLKPSNIVV 157 Q+ G++++HS ++H D+KPSNI + Sbjct: 122 LQVGRGLRYIHSMSLVHMDIKPSNIFI 148 >5L2Q-C nrPDB Length = 320 Score = 40.8 bits (94), Expect = 9e-04, Method: Compositional matrix adjust. Identities = 44/191 (23%), Positives = 82/191 (42%), Gaps = 44/191 (23%) Query: 129 LLYQMLCGIKHLHSAGIIHRDLKPSNIVV-KADCTLKILDFGLAR-TAGTTFMMTPYVVT 186 + Y ++ ++ LH I+HRDLK N+V+ K + I +F L + ++ + Sbjct: 158 IFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEGDLLKDQRGS 217 Query: 187 RYYRAPEVILGMGY-TENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPS 245 Y +P+V+ G Y + D+W++G ++ M+ G FP D I Q Sbjct: 218 PAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQ--FPFYDSIPQ-------------E 262 Query: 246 FMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDP 305 ++++ YT P D R + + L+ K+LV+DP Sbjct: 263 LFRKIKAA---------EYT------------IPEDG-----RVSENTVCLIRKLLVLDP 296 Query: 306 EQRISVDEALK 316 +QR++ + L+ Sbjct: 297 QQRLAAADVLE 307 >3ZBF-A nrPDB Length = 322 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 68/244 (27%), Positives = 98/244 (40%), Gaps = 58/244 (23%) Query: 30 IGSGAQGIV--CAAYDTIT----QQNVAIKKLSRPFQNVTHAKRAY-REFKLMKLVNHKN 82 +GSGA G V A D + + VA+K L + + K + +E LM NH N Sbjct: 41 LGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKK--GSTDQEKIEFLKEAHLMSKFNHPN 98 Query: 83 IIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYL--------LYQML 134 I+ L L E Q Y+++ELM+ + L RM+ L Sbjct: 99 ILKQLGVCL----LNEPQ--YIILELMEGG---DLLTYLRKARMATFYGPLLTLVDLVDL 149 Query: 135 C-----GIKHLHSAGIIHRDLKPSNIVVKA-DCT----LKILDFGLARTAGTTFMMTPYV 184 C G +L IHRDL N +V D T +KI DFGLAR Sbjct: 150 CVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDI---------Y 200 Query: 185 VTRYYR------------APEVILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQ 231 YYR APE ++ +T D+WS G ++ E++ G +P ++D Sbjct: 201 KNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDV 260 Query: 232 WNKI 235 N + Sbjct: 261 LNYV 264 >4M69-B nrPDB Length = 283 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 42/175 (24%), Positives = 73/175 (41%), Gaps = 28/175 (16%) Query: 71 EFKLMKLVNHKNIIGLLNAFTPQ-------RNLEEFQDVYLVMELMDANLCQVIQMDLDH 123 E K MK + NI+ + Q + E+ ++ + EL+D + DL Sbjct: 58 EIKTMKKFDSPNILRIFGICIDQTVKPPEFSIVMEYCELGTLRELLDR------EKDLTM 111 Query: 124 DRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGL-------ARTAGT 176 S L+ + G+ LH + +HR++ S+ +V +K+ F L +RTA + Sbjct: 112 SVRSLLVLRAARGLYRLHHSETLHRNISSSSFLVAGGYQVKLAGFELSKTQNSISRTAKS 171 Query: 177 T----FMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTD 227 T T YV + P + Y +I+S G ++ E+ G + F G D Sbjct: 172 TKAERSSSTIYVSPERLKNPFCL----YDIKAEIYSFGIVLWEIATGKIPFEGCD 222 >4BTF-A nrPDB Length = 469 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 42/175 (24%), Positives = 73/175 (41%), Gaps = 28/175 (16%) Query: 71 EFKLMKLVNHKNIIGLLNAFTPQ-------RNLEEFQDVYLVMELMDANLCQVIQMDLDH 123 E K MK + NI+ + Q + E+ ++ + EL+D + DL Sbjct: 244 EIKTMKKFDSPNILRIFGICIDQTVKPPEFSIVMEYCELGTLRELLDR------EKDLTM 297 Query: 124 DRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGL-------ARTAGT 176 S L+ + G+ LH + +HR++ S+ +V +K+ F L +RTA + Sbjct: 298 SVRSLLVLRAARGLYRLHHSETLHRNISSSSFLVAGGYQVKLAGFELSKTQNSISRTAKS 357 Query: 177 T----FMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTD 227 T T YV + P + Y +I+S G ++ E+ G + F G D Sbjct: 358 TKAERSSSTIYVSPERLKNPFCL----YDIKAEIYSFGIVLWEIATGKIPFEGCD 408 >3LMG-A nrPDB Length = 344 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 25/93 (26%), Positives = 45/93 (48%), Gaps = 3/93 (3%) Query: 132 QMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTR---Y 188 Q+ G+ +L G++HR+L N+++K+ +++ DFG+A Y + Sbjct: 141 QIAKGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIK 200 Query: 189 YRAPEVILGMGYTENVDIWSVGCIMGEMIRGGV 221 + A E I YT D+WS G + E++ G Sbjct: 201 WMALESIHFGKYTHQSDVWSYGVTVWELMTFGA 233 >4IX6-A nrPDB Length = 350 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 16/44 (36%), Positives = 28/44 (63%), Gaps = 2/44 (4%) Query: 130 LYQMLCGIKHLHSAGIIHRDLKPSNIVV--KADCTLKILDFGLA 171 + ++L + LH G++HRD+KP+N++ K LK++D G A Sbjct: 149 MRELLGSLARLHECGVVHRDVKPANLIAAEKDGGVLKLIDLGAA 192 >5X18-A nrPDB Length = 295 Score = 39.3 bits (90), Expect = 0.002, Method: Compositional matrix adjust. Identities = 40/153 (26%), Positives = 70/153 (45%), Gaps = 17/153 (11%) Query: 28 RPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLL 87 + IG G+ G++ + I VAIK R T A + E+K K++N I Sbjct: 13 KKIGEGSFGVLFEGTNMINGVPVAIKFEPRK----TEAPQLRDEYKTYKILNGTPNIPYA 68 Query: 88 NAFTPQRNLEEFQDVYLVMELMDANLCQVIQM---DLDHDRMSYLLYQMLCGIKHLHSAG 144 F Q L LV++L+ +L + + + QM+ I+ LH+ Sbjct: 69 YYFG-QEGLHNI----LVIDLLGPSLEDLFDWCGRKFSVKTVVQVAVQMITLIEDLHAHD 123 Query: 145 IIHRDLKPSNIVV----KADC-TLKILDFGLAR 172 +I+RD+KP N ++ + D + ++DFG+A+ Sbjct: 124 LIYRDIKPDNFLIGRPGQPDANNIHLIDFGMAK 156 >2Y4I-B nrPDB Length = 319 Score = 39.3 bits (90), Expect = 0.002, Method: Compositional matrix adjust. Identities = 40/153 (26%), Positives = 69/153 (45%), Gaps = 18/153 (11%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNA 89 IG G G V Y VAI+ + N K RE + H+N++ + A Sbjct: 41 IGKGRFGQV---YHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQTRHENVVLFMGA 97 Query: 90 -FTPQR-----NLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGIKHLHSA 143 +P +L + + +Y V+ DA + LD ++ + +++ G+ +LH+ Sbjct: 98 CMSPPHLAIITSLCKGRTLYSVVR--DAKIV------LDVNKTRQIAQEIVKGMGYLHAK 149 Query: 144 GIIHRDLKPSNIVVKADCTLKILDFGLARTAGT 176 GI+H+DLK N+ + + I DFGL +G Sbjct: 150 GILHKDLKSKNVFYD-NGKVVITDFGLFSISGV 181 >2CMW-A nrPDB Length = 310 Score = 38.9 bits (89), Expect = 0.003, Method: Compositional matrix adjust. Identities = 17/46 (36%), Positives = 31/46 (67%), Gaps = 5/46 (10%) Query: 132 QMLCGIKHLHSAGIIHRDLKPSNIVV-----KADCTLKILDFGLAR 172 Q+L ++++HS +I+RD+KP N ++ K + + I+DFGLA+ Sbjct: 105 QLLSRMEYVHSKNLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAK 150 >2C47-A nrPDB Length = 313 Score = 38.9 bits (89), Expect = 0.003, Method: Compositional matrix adjust. Identities = 37/153 (24%), Positives = 73/153 (47%), Gaps = 17/153 (11%) Query: 28 RPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLL 87 + IG G G + + T + VAIK P + + A + + E++ K ++ + + Sbjct: 10 KKIGCGNFGELRLGKNLYTNEYVAIK--LEPIK--SRAPQLHLEYRFYKQLSATEGVPQV 65 Query: 88 NAFTPQRNLEEFQDVYLVMELMDANLCQVIQM-DLDHDRMSYLLY--QMLCGIKHLHSAG 144 F P +V+EL+ +L + + D + L+ Q++ ++++H+ Sbjct: 66 YYFGPCGKYNA-----MVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYVHTKS 120 Query: 145 IIHRDLKPSNIVV-----KADCTLKILDFGLAR 172 +I+RD+KP N +V K + I+DFGLA+ Sbjct: 121 LIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAK 153 >5VDK-A nrPDB Length = 297 Score = 38.9 bits (89), Expect = 0.003, Method: Compositional matrix adjust. Identities = 34/153 (22%), Positives = 71/153 (46%), Gaps = 10/153 (6%) Query: 12 EVGDTNFTIHSRY----INLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKR 67 E G TN SRY + + IG G G V + AIK+ + F +++ Sbjct: 3 EFGSTNMA--SRYEKEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENS 60 Query: 68 AYRE-FKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMD--LDHD 124 A E + L +H +++ +++ ++ Q+ Y + A + + + + Sbjct: 61 ALHEVYAHAVLGHHPHVVRYYSSWAEDDHMI-IQNEYCNGGSLQAAISENTKSGNHFEEP 119 Query: 125 RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVV 157 ++ +L Q+ G+ ++H++ ++H D+KPSNI + Sbjct: 120 KLKDILLQISLGLNYIHNSSMVHLDIKPSNIFI 152 >2CHL-A nrPDB Length = 351 Score = 38.9 bits (89), Expect = 0.004, Method: Compositional matrix adjust. Identities = 49/214 (22%), Positives = 93/214 (43%), Gaps = 25/214 (11%) Query: 28 RPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLL 87 + IG G G + + T + VAIK P + + A + + E++ K + + I + Sbjct: 36 KKIGCGNFGELRLGKNLYTNEYVAIK--LEPMK--SRAPQLHLEYRFYKQLGSGDGIPQV 91 Query: 88 NAFTPQRNLEEFQDVYLVMELMDANLCQVIQM-DLDHDRMSYLLY--QMLCGIKHLHSAG 144 F P +V+EL+ +L + + D + L+ Q++ ++++HS Sbjct: 92 YYFGPCGKYNA-----MVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKN 146 Query: 145 IIHRDLKPSNIVV-----KADCTLKILDFGLAR--TAGTTFMMTPY------VVTRYYRA 191 +I+RD+KP N ++ K + I+DF LA+ T PY T Y + Sbjct: 147 LIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMS 206 Query: 192 PEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPG 225 LG + D+ ++G + +RG + + G Sbjct: 207 INTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQG 240 >6G4J-A nrPDB Length = 315 Score = 37.7 bits (86), Expect = 0.009, Method: Compositional matrix adjust. Identities = 37/148 (25%), Positives = 63/148 (42%), Gaps = 8/148 (5%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREF-KLMKLVNHKN 82 Y + +G GA GIV A + +VA+K +S ++T + F K + + Sbjct: 28 YTLRKQLGKGANGIVYLA--ETSDGHVALK-VSDDSLSITSEVNVLKSFSKAQSVTMGPS 84 Query: 83 IIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGIKHLHS 142 +A+ P N + + ME + L D + + L+ Q+L + LH Sbjct: 85 FFDTDDAYIPSANTKV---SFYAMEYIKGPLLLKYVSDKGAEWIPVLMIQLLSSLSVLHQ 141 Query: 143 AGIIHRDLKPSNIVVKA-DCTLKILDFG 169 G I DLKP N++V ++ +D G Sbjct: 142 QGWIFGDLKPDNLIVTGPPARIRCIDVG 169 >5VE6-A nrPDB Length = 492 Score = 37.4 bits (85), Expect = 0.009, Method: Compositional matrix adjust. Identities = 18/40 (45%), Positives = 27/40 (67%), Gaps = 1/40 (2%) Query: 125 RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLK 164 R+ +LL Q+ G++HL GIIHRDL N+++ CTL+ Sbjct: 209 RVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLL-VHCTLQ 247 >4NT4-A nrPDB Length = 312 Score = 37.4 bits (85), Expect = 0.012, Method: Compositional matrix adjust. Identities = 18/46 (39%), Positives = 31/46 (67%), Gaps = 5/46 (10%) Query: 132 QMLCGIKHLHSAGIIHRDLKPSNIVV-----KADCTLKILDFGLAR 172 Q+L I+++HS +I+RD+KP N ++ K + + I+DFGLA+ Sbjct: 122 QLLHRIEYVHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAK 167 >3AOX-A nrPDB Length = 344 Score = 37.4 bits (85), Expect = 0.012, Method: Compositional matrix adjust. Identities = 25/100 (25%), Positives = 40/100 (40%), Gaps = 18/100 (18%) Query: 135 CGIKHLHSAGIIHRDLKPSNIVVKADC---TLKILDFGLAR---------TAGTTFMMTP 182 CG ++L IHRD+ N ++ KI DFG+AR G + Sbjct: 168 CGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVK 227 Query: 183 YVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVL 222 ++ PE + +T D WS G ++ E+ G + Sbjct: 228 WM------PPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYM 261 >6EQI-C nrPDB Length = 433 Score = 36.2 bits (82), Expect = 0.023, Method: Compositional matrix adjust. Identities = 29/100 (29%), Positives = 41/100 (41%), Gaps = 18/100 (18%) Query: 136 GIKHLHSAGIIHRDLKPSNIVV-----KADCTLKILDFGLARTAGTTFMMTPYVV----- 185 + H++ I HRDLK NI+V A T+ I DFG ++ PY Sbjct: 179 AVAHMNIHNISHRDLKSDNILVDLSEGDAYPTIVITDFGCCLCDKQNGLVIPYRSEDQDK 238 Query: 186 --TRYYRAPEVILGMGYT------ENVDIWSVGCIMGEMI 217 R APE+ T + D+W+VG I E+ Sbjct: 239 GGNRALMAPEIANAKPGTFSWLNYKKSDLWAVGAIAYEIF 278 >4L68-A nrPDB Length = 340 Score = 36.2 bits (82), Expect = 0.025, Method: Compositional matrix adjust. Identities = 34/141 (24%), Positives = 60/141 (42%), Gaps = 24/141 (17%) Query: 145 IIHRDLKPSNIVVKADCTLKILDFGLARTA-----GTTFMMTPYVVTRYYRAPEVILGMG 199 I+H+++ S I++ D +I+D GLAR + MT + Y APE M Sbjct: 160 ILHQNICSSVILIDEDFDARIIDSGLARLMVPSDNNESSFMTGDLGEFGYVAPEYSTTML 219 Query: 200 YTENVDIWSVGCIMGEMIR-----GGVLFPGTDHIDQWNKIIEQLGTPSPSF-------- 246 + D++ +G ++ E+ GG F G+ + W K +E G + +F Sbjct: 220 ASLKGDVYGLGVVLLELATGLKAVGGEGFKGS--LVDWVKQLESSGRIAETFDENIRGKG 277 Query: 247 ----MQRLQPTVRNYVENRPR 263 + + N V +RP+ Sbjct: 278 HDEEISKFVEIALNCVSSRPK 298 >6EWX-A nrPDB Length = 484 Score = 35.4 bits (80), Expect = 0.038, Method: Compositional matrix adjust. Identities = 15/33 (45%), Positives = 23/33 (69%) Query: 125 RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVV 157 R+ +LL Q+ G++HL GIIHRDL N+++ Sbjct: 211 RVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLL 243 >6M7Z-A nrPDB Length = 319 Score = 35.4 bits (80), Expect = 0.040, Method: Compositional matrix adjust. Identities = 36/185 (19%), Positives = 80/185 (43%), Gaps = 22/185 (11%) Query: 103 YLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCT 162 Y+ L + +++ H + L M+ +K LH+ G++HR ++ ++ V D T Sbjct: 123 YIFHPLSKGLVGDMLETGRSHPDVQVLAANMVAALKSLHNLGLLHRSIELNSFSVLPDGT 182 Query: 163 LKILDFGLARTAGTTFMM--------TPYVVTRYYRAPEVILGMGYTENVDIWSVGCI-- 212 + + A GT + T + R + A + +T D++S+G Sbjct: 183 VVLGGLDTAAPIGTETRLWVGFFGQETAPEIDRNFLADLALTQGRHTVKSDVYSLGVAFR 242 Query: 213 -MGEMIRGGVLFPG------TDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENRPRYT 265 + +++ G L P DH++ +K+ +++ P +PT+ +++ P + Sbjct: 243 NLVQLLGNGNLGPEDRGAVRQDHLELLDKLSQKMIEEEPGN----RPTIEEIMKD-PLFE 297 Query: 266 GYSFD 270 G +F+ Sbjct: 298 GLNFE 302 >4YFF-A nrPDB Length = 311 Score = 35.4 bits (80), Expect = 0.043, Method: Compositional matrix adjust. Identities = 28/102 (27%), Positives = 44/102 (43%), Gaps = 23/102 (22%) Query: 136 GIKHLH--SAGIIHRDLKPSNIVVKADCTLKILDFG------------LARTAGTTFMMT 181 G+++LH + IIHRDL NI++ D + DFG + + G M Sbjct: 154 GMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMA 213 Query: 182 PYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLF 223 P V T+ R YT D++S + E++ G + F Sbjct: 214 PEVFTQCTR---------YTIKADVFSYALCLWEILTGEIPF 246 >4AZV-A nrPDB Length = 569 Score = 35.0 bits (79), Expect = 0.050, Method: Compositional matrix adjust. Identities = 20/73 (27%), Positives = 34/73 (46%) Query: 97 EEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIV 156 E Q +LVME + L + + +L +L + L G H D++P N++ Sbjct: 312 ENAQSGWLVMEKLPGRLLSDMLAAGEEIDREKILGSLLRSLAALEKQGFWHDDVRPWNVM 371 Query: 157 VKADCTLKILDFG 169 V A +++DFG Sbjct: 372 VDARQHARLIDFG 384 >6BFN-A nrPDB Length = 342 Score = 35.0 bits (79), Expect = 0.051, Method: Compositional matrix adjust. Identities = 30/95 (31%), Positives = 45/95 (47%), Gaps = 12/95 (12%) Query: 137 IKHLH--SAGIIHRDLKPSNIVVKADCTLKILDFGLA---RTAGTTFMMTPYVV------ 185 I+ LH S +IH D+K SN+++ T K+ DFGLA R AG++ + V Sbjct: 138 IQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVR 197 Query: 186 -TRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRG 219 T Y E I + D +S G ++ E + G Sbjct: 198 GTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAG 232 >4AZW-A nrPDB Length = 471 Score = 35.0 bits (79), Expect = 0.055, Method: Compositional matrix adjust. Identities = 20/73 (27%), Positives = 34/73 (46%) Query: 97 EEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIV 156 E Q +LVME + L + + +L +L + L G H D++P N++ Sbjct: 312 ENAQSGWLVMEKLPGRLLSDMLAAGEEIDREKILGSLLRSLAALEKKGFWHDDVRPWNVM 371 Query: 157 VKADCTLKILDFG 169 V A +++DFG Sbjct: 372 VDARQHARLIDFG 384 >6FAI-l nrPDB Length = 425 Score = 33.5 bits (75), Expect = 0.17, Method: Compositional matrix adjust. Identities = 31/123 (25%), Positives = 55/123 (44%), Gaps = 19/123 (15%) Query: 54 KLSRPFQNVTHAKR--AYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDA 111 K S N H R A +E++ M ++ K + F R++ +VMEL++ Sbjct: 143 KKSNQGANWMHLSRLAANKEYQFMSMLYSKGF-KVPEPFDNSRHI-------VVMELIEG 194 Query: 112 NLCQVIQMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK------ADCTLKI 165 + ++ H + L ++C I L ++G+IH D NI++K DC + Sbjct: 195 YPMRRLRK---HKNIPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGFVV 251 Query: 166 LDF 168 +DF Sbjct: 252 IDF 254 >6J6I-B nrPDB Length = 351 Score = 33.1 bits (74), Expect = 0.22, Method: Compositional matrix adjust. Identities = 25/90 (27%), Positives = 45/90 (50%), Gaps = 6/90 (6%) Query: 136 GIKHLHSAG---IIHRDLKPSNIVVKADCTLKI--LDFGLARTAGTTFMMTPYVVTRY-Y 189 + +LH+A IIHRD+KP ++ + + T K+ L F ++ G + + +V+ + Y Sbjct: 175 AVTYLHTAFPKIIIHRDVKPMHVFLDKNWTAKLSDLSFSISLPEGKSRIEAEWVLGTFGY 234 Query: 190 RAPEVILGMGYTENVDIWSVGCIMGEMIRG 219 P TE D++S G + +I G Sbjct: 235 IDPLYHKTCFVTEYTDVYSFGICLLVIITG 264 >3ENH-A nrPDB Length = 540 Score = 32.7 bits (73), Expect = 0.26, Method: Compositional matrix adjust. Identities = 36/150 (24%), Positives = 64/150 (42%), Gaps = 19/150 (12%) Query: 30 IGSGAQGIV----CAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIG 85 IG GA+ + +D I ++ V R RE + + LV G Sbjct: 344 IGKGAEADIKRDSYLDFDVIIKERVKKGYRDERLDENIRKSRTAREARYLALVKD---FG 400 Query: 86 LLNAFTPQRNLEEFQDVYLVMELMDANLCQ-VIQMDLDHDRMSYLLYQMLCGIKHLHSAG 144 + + +L+ + ++M ++ L + VI+ +LD + Y++ + LH Sbjct: 401 IPAPYIFDVDLDNKR---IMMSYINGKLAKDVIEDNLD------IAYKIGEIVGKLHKND 451 Query: 145 IIHRDLKPSNIVVKADCTLKILDFGLARTA 174 +IH DL SN + D L I+DFGL + + Sbjct: 452 VIHNDLTTSNFIFDKD--LYIIDFGLGKIS 479 >6DC0-A nrPDB Length = 292 Score = 32.7 bits (73), Expect = 0.28, Method: Compositional matrix adjust. Identities = 33/166 (19%), Positives = 68/166 (40%), Gaps = 9/166 (5%) Query: 75 MKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQML 134 ++L +H NI G++ + V+ + D + + L + + L Q++ Sbjct: 52 IQLPSHSNITGIVEVILGETK----AYVFFEKDFGDMHSYVRSRKRLREEEAARLFKQIV 107 Query: 135 CGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLART---AGTTFMMTPYVVTRYYRA 191 + H H + I+ DLK V + ++ L T G ++ Y + Sbjct: 108 SAVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVS 167 Query: 192 PEVI--LGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKI 235 PE++ G + D+WS+G ++ ++ G F +D ++KI Sbjct: 168 PEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKI 213 >5CEK-A nrPDB Length = 263 Score = 32.3 bits (72), Expect = 0.32, Method: Compositional matrix adjust. Identities = 33/166 (19%), Positives = 68/166 (40%), Gaps = 9/166 (5%) Query: 75 MKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQML 134 ++L +H NI G++ + V+ + D + + L + + L Q++ Sbjct: 55 IQLPSHSNITGIVEVILGETK----AYVFFEKDFGDMHSYVRSRKRLREEEAARLFKQIV 110 Query: 135 CGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLART---AGTTFMMTPYVVTRYYRA 191 + H H + I+ DLK V + ++ L T G ++ Y + Sbjct: 111 SAVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVS 170 Query: 192 PEVI--LGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKI 235 PE++ G + D+WS+G ++ ++ G F +D ++KI Sbjct: 171 PEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKI 216 >5M07-A nrPDB Length = 276 Score = 32.0 bits (71), Expect = 0.49, Method: Compositional matrix adjust. Identities = 13/39 (33%), Positives = 24/39 (61%), Gaps = 4/39 (10%) Query: 137 IKHLHSAGIIHRDLKPSNIVV----KADCTLKILDFGLA 171 + + H G++HRD+ P+N+V+ D + + DFG+A Sbjct: 145 LDYAHQRGLLHRDVNPANVVLTSQSAGDQRILLADFGIA 183 >4O1O-A nrPDB Length = 717 Score = 31.2 bits (69), Expect = 0.70, Method: Compositional matrix adjust. Identities = 13/40 (32%), Positives = 22/40 (55%) Query: 129 LLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDF 168 +L + I LH +G H+DL+P NI++ + + DF Sbjct: 447 ILSSLFKAIGELHRSGYSHQDLQPQNILIDSKNGTFLADF 486 >1LLQ-A nrPDB Length = 605 Score = 30.8 bits (68), Expect = 1.0, Method: Compositional matrix adjust. Identities = 26/98 (26%), Positives = 47/98 (47%), Gaps = 10/98 (10%) Query: 47 QQNVAIKKLSRPFQNVTHAKRAYREFKLMKL-------VNHKNIIGLLNAFTPQRNLEEF 99 ++ +A+ KL RP + VT KR+ K +L + + +GL P +E Sbjct: 19 EKEMALYKLYRP-ERVTPKKRSAELLKEPRLNKGMGFSLYERQYLGLHGLLPPAFMTQEQ 77 Query: 100 QDVYLVMELMDA--NLCQVIQMDLDHDRMSYLLYQMLC 135 Q ++ +L + +L + IQ+D DR L Y+++C Sbjct: 78 QAYRVITKLREQPNDLARYIQLDGLQDRNEKLFYRVVC 115 >6MC8-A nrPDB Length = 308 Score = 30.0 bits (66), Expect = 1.5, Method: Compositional matrix adjust. Identities = 28/90 (31%), Positives = 40/90 (44%), Gaps = 11/90 (12%) Query: 93 QRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGIKHL-HSAGIIHRDLK 151 Q +++ D ++A L Q ++ L HDR G+ HL HSA +IH D Sbjct: 49 QSDVQALADSGADDTTLEAQLTQ--ELRLAHDRWG-------LGLLHLQHSARLIHTDGV 99 Query: 152 PSNIVVKADCTLKI-LDFGLARTAGTTFMM 180 PS+I + D + L G AGT M Sbjct: 100 PSDIALLVDGAPRAQLSDGARAIAGTYASM 129 >4OAU-C nrPDB Length = 699 Score = 30.0 bits (66), Expect = 1.8, Method: Compositional matrix adjust. Identities = 37/168 (22%), Positives = 74/168 (44%), Gaps = 19/168 (11%) Query: 6 HQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHA 65 H+ Y +G F I +Y + + GI Y+ +Q VA+K + Sbjct: 331 HRIYRPMIGKLKFFIDEKY---KIADTSEGGIYLGFYE---KQEVAVKTFCEG------S 378 Query: 66 KRAYREFKLMKLV-NHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHD 124 RA RE ++ + +++ + + + +L F V L + ++A L D++++ Sbjct: 379 PRAQREVSCLQSSRENSHLVTFYGSESHRGHL--FVCVTLCEQTLEACLDVHRGEDVENE 436 Query: 125 RMSY---LLYQMLCGIKHLH-SAGIIHRDLKPSNIVVKADCTLKILDF 168 + +L + ++ LH S G H+DL+P NI++ + + DF Sbjct: 437 EDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADF 484 >5DMZ-A nrPDB Length = 365 Score = 29.6 bits (65), Expect = 1.9, Method: Compositional matrix adjust. Identities = 30/135 (22%), Positives = 50/135 (37%), Gaps = 32/135 (23%) Query: 132 QMLCGIKHLHSAGIIHRDLKPSNIVV-----------KADCTLKILDFGLA-----RTAG 175 +ML I+ +H IIH D+KP N ++ L ++D G + G Sbjct: 180 RMLYMIEQVHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMKLFPKG 239 Query: 176 TTFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGV-------------- 221 T F T T ++ E++ + +D + V + M+ G Sbjct: 240 TIF--TAKCETSGFQCVEMLSNKPWNYQIDYFGVAATVYCMLFGTYMKVKNEGGECKPEG 297 Query: 222 LFPGTDHIDQWNKII 236 LF H+D WN+ Sbjct: 298 LFRRLPHLDMWNEFF 312 >2OR0-A nrPDB Length = 414 Score = 29.6 bits (65), Expect = 2.2, Method: Compositional matrix adjust. Identities = 15/72 (20%), Positives = 31/72 (43%), Gaps = 4/72 (5%) Query: 145 IIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAP----EVILGMGY 200 ++ +++ + +ADC L GL R +G ++ P + Y P E ++G+ Sbjct: 31 VVAEEIRGQAVQSEADCRLTDAAAGLLRDSGAIRLLQPRLYGGYEVHPREFAETVMGVAA 90 Query: 201 TENVDIWSVGCI 212 + W G + Sbjct: 91 LDGASGWVTGIV 102 >5DLD-A nrPDB Length = 413 Score = 29.6 bits (65), Expect = 2.3, Method: Compositional matrix adjust. Identities = 26/89 (29%), Positives = 36/89 (40%), Gaps = 18/89 (20%) Query: 120 DLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFM 179 DLD R L + GI LH+ G + DL+P ++V D T TT Sbjct: 66 DLDLMRQGQTLSDVTTGI--LHAIGAVFDDLRPDIVLVHGDTT-------------TTLA 110 Query: 180 MTPYVVTRYYRAPEVILGMGYTENVDIWS 208 ++ RY V G+ + DIWS Sbjct: 111 VSLAAFYRYLPIGHVEAGL---RSGDIWS 136 >3Q60-A nrPDB Length = 371 Score = 29.3 bits (64), Expect = 2.7, Method: Compositional matrix adjust. Identities = 35/154 (22%), Positives = 54/154 (35%), Gaps = 30/154 (19%) Query: 129 LLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRY 188 L Q++ +L S G++H P N+ + D L + D GT + VT Sbjct: 199 LTAQLIRLAANLQSKGLVHGHFTPDNLFIMPDGRLMLGDVSALWKVGTRGPASSVPVT-- 256 Query: 189 YRAPEVILGMG---YTENVDIWSVGC------------------IMGEMIRGGVLFPGTD 227 AP L +T ++ W +G I G R + PGTD Sbjct: 257 -YAPREFLNASTATFTHALNAWQLGLSIYRVWCLFLPFGLVTPGIKGSWKRPSLRVPGTD 315 Query: 228 HIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENR 261 + + TP P F++ L N+ R Sbjct: 316 SLAFGS------CTPLPDFVKTLIGRFLNFDRRR 343 >1Z3I-X nrPDB Length = 644 Score = 28.5 bits (62), Expect = 4.7, Method: Compositional matrix adjust. Identities = 30/105 (28%), Positives = 45/105 (42%), Gaps = 21/105 (20%) Query: 149 DLKPSNIVVKA-----DCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGYTEN 203 DL P N KA + +LD+ LA T TT + +V+L YT+ Sbjct: 382 DLFPQNYSTKAVEPQLSGKMLVLDYILAMTRTTT-------------SDKVVLVSNYTQT 428 Query: 204 VDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTP-SPSFM 247 +D++ C + V GT I + KI+E+ P SP F+ Sbjct: 429 LDLFEKLCRNRRYLY--VRLDGTMSIKKRAKIVERFNNPSSPEFI 471 >2KC5-A nrPDB Length = 162 Score = 28.5 bits (62), Expect = 5.3, Method: Compositional matrix adjust. Identities = 12/38 (31%), Positives = 21/38 (55%), Gaps = 1/38 (2%) Query: 207 WSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSP 244 W+ GC++ + V+FPG D + K+ E++G P Sbjct: 52 WT-GCVITPWMLSAVIFPGPDQLWPLRKVSEKIGLQLP 88 >1H4P-A nrPDB Length = 408 Score = 27.7 bits (60), Expect = 8.4, Method: Compositional matrix adjust. Identities = 21/83 (25%), Positives = 37/83 (44%) Query: 72 FKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLY 131 +K ++ N I +LN + + EE+ D+ + +EL++ L V+ MD + Y Sbjct: 153 YKFLEDSNLAVTINVLNYILKKYSAEEYLDIVIGIELINEPLGPVLDMDKMKNDYLAPAY 212 Query: 132 QMLCGIKHLHSAGIIHRDLKPSN 154 + L IIH +P N Sbjct: 213 EYLRNNIKSDQVIIIHDAFQPYN 235 >5UU1-A nrPDB Length = 324 Score = 27.7 bits (60), Expect = 9.2, Method: Compositional matrix adjust. Identities = 32/164 (19%), Positives = 75/164 (45%), Gaps = 14/164 (8%) Query: 22 SRYINLRPIGSGAQGIVCAAYDTITQQN-------VAIKKLSRPFQNVTHAKRAYREFKL 74 ++++ + IGSG G++ A+ T + V ++ F + +R ++ + Sbjct: 16 NQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDCI 75 Query: 75 MKLVNHKNIIGLLNAFTPQRNLEEFQDV---YLVMELMDANLCQVIQMDLDHDRMSYLLY 131 K + K + L L EF+ ++VME + +L ++ + + + L Sbjct: 76 KKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQNGTFKKSTVLQL 135 Query: 132 --QMLCGIKHLHSAGIIHRDLKPSNIVV--KADCTLKILDFGLA 171 +ML ++++H +H D+K +N+++ K + + D+GL+ Sbjct: 136 GIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLS 179 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 5AWM-A nrPDB 541 e-154 1JNK-A nrPDB 492 e-139 2XS0-A nrPDB 487 e-138 3E7O-A nrPDB 464 e-131 3FI2-A nrPDB 451 e-127 4EWQ-A nrPDB 385 e-107 3OHT-A nrPDB 384 e-107 3GC9-A nrPDB 383 e-107 1CM8-A nrPDB 383 e-107 4MYG-A nrPDB 376 e-104 4IC8-A nrPDB 354 3e-98 4ZSG-A nrPDB 344 4e-95 5Z33-A nrPDB 343 6e-95 6DTL-A nrPDB 343 1e-94 4QTB-A nrPDB 342 1e-94 5NGU-A nrPDB 336 7e-93 2F9G-A nrPDB 330 8e-91 3OZ6-A nrPDB 323 7e-89 4O2Z-A nrPDB 315 3e-86 4QNY-A nrPDB 312 2e-85 3NIZ-A nrPDB 310 7e-85 2BPM-A nrPDB 310 9e-85 6GU6-A nrPDB 298 2e-81 4AU8-A nrPDB 294 5e-80 1V0B-A nrPDB 293 6e-80 4KRC-A nrPDB 293 1e-79 3NCG-A nrPDB 292 1e-79 3RP9-A nrPDB 291 3e-79 5JN2-A nrPDB 291 5e-79 1G3N-A nrPDB 289 1e-78 3DFA-A nrPDB 289 1e-78 4BBM-A nrPDB 288 2e-78 5EFQ-A nrPDB 288 3e-78 4AGU-A nrPDB 286 1e-77 3LIJ-A nrPDB 285 2e-77 5KZ7-A nrPDB 284 3e-77 2VZ6-A nrPDB 284 5e-77 5ES1-A nrPDB 284 5e-77 3N9X-A nrPDB 283 6e-77 3PG1-A nrPDB 283 1e-76 3MA6-A nrPDB 283 1e-76 4NST-A nrPDB 283 1e-76 3HZT-A nrPDB 281 3e-76 2W96-B nrPDB 279 1e-75 2QNJ-A nrPDB 279 1e-75 1UA2-A nrPDB 278 2e-75 3DXN-A nrPDB 278 2e-75 4MVF-A nrPDB 278 4e-75 4E7W-A nrPDB 276 1e-74 3MIA-A nrPDB 276 1e-74 3NIE-A nrPDB 275 2e-74 5AIR-A nrPDB 274 4e-74 4RGJ-A nrPDB 273 7e-74 2VN9-A nrPDB 273 8e-74 5U6Y-A nrPDB 273 1e-73 2BDW-A nrPDB 271 3e-73 2V7O-A nrPDB 271 3e-73 4CFF-A nrPDB 271 4e-73 4BGQ-A nrPDB 271 4e-73 2I6L-A nrPDB 270 8e-73 5EZV-A nrPDB 269 1e-72 5FG8-A nrPDB 268 2e-72 4YZB-A nrPDB 268 3e-72 3GC0-A nrPDB 268 3e-72 3KK8-A nrPDB 268 3e-72 4REW-A nrPDB 266 8e-72 3BHH-A nrPDB 266 1e-71 5G6V-A nrPDB 265 2e-71 5Y86-A nrPDB 265 2e-71 3SOA-A nrPDB 264 4e-71 3EB0-A nrPDB 264 5e-71 3E3P-A nrPDB 264 5e-71 3ZDU-A nrPDB 263 7e-71 3H4J-B nrPDB 263 8e-71 5IG1-A nrPDB 263 9e-71 3MN3-A nrPDB 263 1e-70 4FG9-A nrPDB 262 2e-70 4RED-A nrPDB 262 2e-70 4CFH-A nrPDB 261 4e-70 2JC6-A nrPDB 261 4e-70 6C9D-A nrPDB 260 8e-70 2HAK-A nrPDB 259 1e-69 5XZW-A nrPDB 258 3e-69 3Q5I-A nrPDB 258 4e-69 2YCR-A nrPDB 257 7e-69 3COM-A nrPDB 257 7e-69 6FD3-A nrPDB 255 2e-68 3TAC-A nrPDB 254 3e-68 4NIF-A nrPDB 254 4e-68 5WAX-A nrPDB 253 8e-68 4CZT-A nrPDB 252 1e-67 5ZTN-A nrPDB 252 1e-67 4LG4-A nrPDB 252 1e-67 4JG6-A nrPDB 252 2e-67 3I6U-A nrPDB 252 2e-67 4PDS-A nrPDB 251 5e-67 6AO5-A nrPDB 250 6e-67 2J90-A nrPDB 250 8e-67 2JAM-A nrPDB 249 1e-66 4KS7-A nrPDB 248 2e-66 2YZA-A nrPDB 248 3e-66 3F3Z-A nrPDB 247 7e-66 2W4O-A nrPDB 246 1e-65 4D28-A nrPDB 246 1e-65 2F57-A nrPDB 246 1e-65 3Q53-A nrPDB 246 1e-65 4FIE-A nrPDB 246 2e-65 3ZUT-A nrPDB 246 2e-65 3IS5-A nrPDB 245 2e-65 4D2V-A nrPDB 244 4e-65 4JDH-A nrPDB 244 4e-65 2Q0N-A nrPDB 244 5e-65 4XBR-A nrPDB 243 7e-65 3UDB-A nrPDB 243 7e-65 2YAB-A nrPDB 243 8e-65 2UV2-A nrPDB 243 1e-64 4CQG-A nrPDB 243 1e-64 3UC3-A nrPDB 242 1e-64 4UZD-A nrPDB 242 1e-64 3D2K-A nrPDB 242 1e-64 2JD5-A nrPDB 242 3e-64 3GUB-A nrPDB 241 3e-64 5JZN-A nrPDB 241 4e-64 6FDY-U nrPDB 241 5e-64 5YKS-A nrPDB 240 7e-64 5D9K-A nrPDB 240 9e-64 6O6Q-A nrPDB 239 1e-63 3UTO-A nrPDB 239 2e-63 2A27-A nrPDB 238 2e-63 2Y7J-A nrPDB 237 4e-63 5KCV-A nrPDB 237 4e-63 2Z7Q-A nrPDB 237 5e-63 4L42-A nrPDB 237 5e-63 1ZWS-A nrPDB 237 6e-63 3MV5-A nrPDB 237 6e-63 1KOA-A nrPDB 236 1e-62 4I6B-A nrPDB 236 1e-62 2X4F-A nrPDB 236 2e-62 5F9E-A nrPDB 235 2e-62 1PHK-A nrPDB 235 3e-62 4QMW-A nrPDB 235 3e-62 4RLP-A nrPDB 234 3e-62 2WO6-A nrPDB 234 4e-62 2XIK-A nrPDB 234 5e-62 3LM0-A nrPDB 234 6e-62 1FOT-A nrPDB 234 7e-62 3KN6-A nrPDB 234 7e-62 3DAK-A nrPDB 233 7e-62 4B6L-A nrPDB 232 1e-61 2JDO-A nrPDB 232 1e-61 5X8I-B nrPDB 232 1e-61 5D7A-A nrPDB 232 2e-61 4IAN-A nrPDB 232 2e-61 3HDN-A nrPDB 232 2e-61 4YNZ-A nrPDB 231 3e-61 4CSV-A nrPDB 231 3e-61 3HKO-A nrPDB 231 3e-61 4FZF-B nrPDB 231 4e-61 1KOB-A nrPDB 231 4e-61 3DB8-A nrPDB 231 5e-61 4JXF-A nrPDB 230 7e-61 5DBX-A nrPDB 229 1e-60 2HW6-A nrPDB 229 1e-60 3TXO-A nrPDB 228 3e-60 5KKR-C nrPDB 228 4e-60 6HXF-B nrPDB 227 8e-60 6CMJ-A nrPDB 226 1e-59 2OU7-A nrPDB 226 1e-59 6FYV-A nrPDB 226 2e-59 4APC-A nrPDB 225 2e-59 1U5R-A nrPDB 225 2e-59 4B8L-A nrPDB 225 2e-59 5DYK-A nrPDB 225 2e-59 3EQC-A nrPDB 225 3e-59 1NY3-A nrPDB 224 3e-59 4J52-A nrPDB 224 4e-59 6QAU-A nrPDB 224 4e-59 3KA0-A nrPDB 224 5e-59 5J5T-A nrPDB 224 6e-59 2GCD-A nrPDB 224 7e-59 2OZA-A nrPDB 223 8e-59 1VZO-A nrPDB 223 1e-58 5FET-A nrPDB 222 1e-58 4WNO-A nrPDB 222 2e-58 6CKI-A nrPDB 222 2e-58 2XYN-A nrPDB 222 2e-58 3FXW-A nrPDB 222 2e-58 4AF3-A nrPDB 222 2e-58 2X7G-A nrPDB 222 3e-58 2PVN-A nrPDB 221 6e-58 3NYO-A nrPDB 220 8e-58 6ED6-A nrPDB 220 9e-58 3ORZ-A nrPDB 219 1e-57 5LOH-A nrPDB 219 2e-57 6E9W-A nrPDB 219 2e-57 5N23-A nrPDB 219 2e-57 5X3F-B nrPDB 218 2e-57 5YV8-A nrPDB 218 3e-57 4RA4-A nrPDB 218 3e-57 4U41-A nrPDB 217 5e-57 3PPZ-A nrPDB 217 6e-57 6CQF-A nrPDB 217 8e-57 4WB7-A nrPDB 216 1e-56 3RAW-A nrPDB 216 1e-56 4EBW-A nrPDB 216 1e-56 3ALO-A nrPDB 216 2e-56 3VN9-A nrPDB 215 2e-56 4CRL-A nrPDB 215 2e-56 4WUA-A nrPDB 215 2e-56 2FO0-A nrPDB 214 4e-56 4XEY-B nrPDB 214 5e-56 4P5Q-A nrPDB 214 6e-56 4C0T-A nrPDB 213 9e-56 6BDL-A nrPDB 213 1e-55 6NPU-A nrPDB 212 1e-55 4TNB-A nrPDB 212 2e-55 4MD7-E nrPDB 212 2e-55 5UNP-A nrPDB 212 2e-55 4AN9-A nrPDB 212 2e-55 6HMD-A nrPDB 211 3e-55 4KIK-B nrPDB 211 3e-55 3TKU-A nrPDB 211 4e-55 5XVU-A nrPDB 210 7e-55 2WTK-C nrPDB 210 8e-55 4UY9-A nrPDB 210 1e-54 3PFQ-A nrPDB 210 1e-54 1S9I-A nrPDB 209 1e-54 5MJB-A nrPDB 209 1e-54 2WQN-A nrPDB 209 1e-54 3DTC-A nrPDB 209 2e-54 5H2U-A nrPDB 209 2e-54 3C51-A nrPDB 208 3e-54 4AW2-A nrPDB 208 4e-54 6E2O-A nrPDB 208 4e-54 2I0E-A nrPDB 207 4e-54 5VO2-A nrPDB 207 5e-54 2J0K-A nrPDB 207 5e-54 1JPA-A nrPDB 207 6e-54 6EII-A nrPDB 207 7e-54 3A8W-A nrPDB 207 8e-54 2Y6O-A nrPDB 207 9e-54 2BRG-A nrPDB 207 9e-54 5L6P-A nrPDB 207 9e-54 3QA8-A nrPDB 207 9e-54 3FME-A nrPDB 206 1e-53 4UYA-A nrPDB 206 1e-53 2H8H-A nrPDB 206 1e-53 6F3F-A nrPDB 206 1e-53 1TKI-A nrPDB 206 2e-53 2R2P-A nrPDB 206 2e-53 4E93-A nrPDB 206 2e-53 5X5O-A nrPDB 205 2e-53 6CCF-A nrPDB 205 3e-53 2XNP-A nrPDB 205 3e-53 2VWV-A nrPDB 205 3e-53 3DKO-A nrPDB 205 3e-53 4OLI-A nrPDB 204 5e-53 3ORP-A nrPDB 204 5e-53 4FR4-A nrPDB 204 5e-53 5B2L-A nrPDB 203 9e-53 2DQ7-X nrPDB 203 1e-52 3TT0-A nrPDB 202 2e-52 5A46-A nrPDB 202 2e-52 5SYS-A nrPDB 202 3e-52 4EQM-A nrPDB 202 3e-52 6DBM-A nrPDB 202 3e-52 4YHJ-A nrPDB 201 3e-52 3GQL-A nrPDB 201 5e-52 2PSQ-A nrPDB 199 1e-51 5TQX-A nrPDB 199 1e-51 3A4O-X nrPDB 199 2e-51 4XCU-A nrPDB 199 2e-51 4AT3-A nrPDB 199 2e-51 4PWN-A nrPDB 198 3e-51 3KUL-B nrPDB 198 3e-51 4GS6-A nrPDB 198 4e-51 6BXI-A nrPDB 198 4e-51 4PDO-A nrPDB 197 5e-51 6GQK-A nrPDB 197 5e-51 5O2B-A nrPDB 197 6e-51 5EG3-A nrPDB 197 6e-51 4E20-A nrPDB 197 8e-51 4K33-A nrPDB 197 8e-51 2HK5-A nrPDB 196 1e-50 2PL0-A nrPDB 196 2e-50 5O2C-A nrPDB 196 2e-50 2VD5-A nrPDB 195 2e-50 5KMM-A nrPDB 195 2e-50 5U6B-A nrPDB 195 2e-50 4CRS-A nrPDB 195 2e-50 4OTD-A nrPDB 195 2e-50 3QGY-A nrPDB 195 3e-50 1FVR-A nrPDB 195 3e-50 4M7I-A nrPDB 194 5e-50 4Y93-A nrPDB 194 5e-50 2OGV-A nrPDB 194 6e-50 5HIE-A nrPDB 193 9e-50 3BBT-B nrPDB 193 9e-50 3V5Q-A nrPDB 193 1e-49 1U59-A nrPDB 193 1e-49 5HI2-A nrPDB 193 1e-49 4XI2-A nrPDB 193 1e-49 1AD5-A nrPDB 192 1e-49 4H1J-A nrPDB 192 2e-49 1BYG-A nrPDB 192 2e-49 6GVJ-A nrPDB 192 2e-49 4XUF-A nrPDB 192 2e-49 3CJF-A nrPDB 192 2e-49 5AMN-A nrPDB 192 3e-49 2OZO-A nrPDB 192 3e-49 3OMV-A nrPDB 192 3e-49 3M42-A nrPDB 191 3e-49 5AP3-A nrPDB 191 3e-49 3QUP-A nrPDB 191 3e-49 3BEA-A nrPDB 191 4e-49 1LUF-A nrPDB 191 4e-49 3SXS-A nrPDB 191 5e-49 1K9A-A nrPDB 191 5e-49 6E4F-A nrPDB 190 6e-49 5X02-A nrPDB 190 6e-49 3KRL-A nrPDB 190 6e-49 3DLS-A nrPDB 190 7e-49 6DBN-A nrPDB 190 7e-49 4OW8-A nrPDB 190 9e-49 6B2Q-A nrPDB 190 9e-49 4X3F-A nrPDB 190 9e-49 1ZXE-A nrPDB 190 1e-48 3ZBF-A nrPDB 190 1e-48 2A1A-B nrPDB 189 1e-48 2W1I-A nrPDB 189 1e-48 3C1X-A nrPDB 189 1e-48 5HLW-A nrPDB 189 2e-48 3G0E-A nrPDB 189 2e-48 4R7H-A nrPDB 189 2e-48 4LFI-A nrPDB 188 4e-48 3IO7-A nrPDB 187 6e-48 4XLV-A nrPDB 187 6e-48 4HZS-A nrPDB 187 6e-48 3HMP-A nrPDB 187 6e-48 3UIU-A nrPDB 187 7e-48 3PP0-A nrPDB 187 7e-48 6FEX-A nrPDB 187 7e-48 5FM2-A nrPDB 187 9e-48 5UUU-A nrPDB 186 1e-47 3PLS-A nrPDB 186 1e-47 5GNK-A nrPDB 186 1e-47 3PVW-A nrPDB 186 2e-47 1U54-B nrPDB 185 2e-47 3LZB-A nrPDB 185 2e-47 5UIU-A nrPDB 185 2e-47 3I81-A nrPDB 185 3e-47 6CTH-A nrPDB 185 3e-47 5GRN-A nrPDB 185 3e-47 6BSD-A nrPDB 185 4e-47 2ZMD-A nrPDB 184 4e-47 5TUR-A nrPDB 184 4e-47 5HVK-A nrPDB 184 5e-47 4TPT-A nrPDB 184 6e-47 3BGP-A nrPDB 184 7e-47 3LLT-A nrPDB 184 8e-47 5U6C-A nrPDB 183 8e-47 2WTK-B nrPDB 183 1e-46 6FER-A nrPDB 182 2e-46 4HVI-A nrPDB 182 3e-46 4RC3-A nrPDB 180 8e-46 4LRM-A nrPDB 180 1e-45 4Y83-A nrPDB 179 2e-45 4JLC-A nrPDB 177 8e-45 4EUU-A nrPDB 177 8e-45 5VD3-A nrPDB 177 1e-44 4EUT-A nrPDB 175 2e-44 5O0Y-A nrPDB 175 3e-44 4NEU-A nrPDB 174 5e-44 4FL3-A nrPDB 173 9e-44 4C59-A nrPDB 173 1e-43 6O8B-A nrPDB 172 2e-43 4X7Q-B nrPDB 172 2e-43 6NT9-A nrPDB 172 2e-43 3ZZW-A nrPDB 172 2e-43 5WNO-A nrPDB 172 3e-43 5TOS-A nrPDB 171 4e-43 5C26-A nrPDB 170 1e-42 4IDT-A nrPDB 169 2e-42 5WNL-A nrPDB 168 3e-42 3QD2-B nrPDB 168 3e-42 4G3E-A nrPDB 168 4e-42 5LPZ-A nrPDB 167 7e-42 5LPV-A nrPDB 167 1e-41 2BUJ-A nrPDB 166 1e-41 6HV0-A nrPDB 166 1e-41 4PL5-B nrPDB 165 2e-41 4F0G-A nrPDB 165 3e-41 2H34-A nrPDB 165 3e-41 5TE0-A nrPDB 164 6e-41 3HNG-A nrPDB 164 9e-41 3Q4U-A nrPDB 163 1e-40 2RIO-A nrPDB 162 2e-40 3MDY-A nrPDB 160 1e-39 6J5U-C nrPDB 159 2e-39 4F9B-A nrPDB 157 7e-39 3LMG-A nrPDB 157 8e-39 2PMN-X nrPDB 156 1e-38 3MY0-A nrPDB 156 1e-38 3UIM-A nrPDB 156 1e-38 2QKW-B nrPDB 155 3e-38 5IKW-A nrPDB 155 3e-38 1PY5-A nrPDB 153 1e-37 3SOC-A nrPDB 152 2e-37 4M66-A nrPDB 152 2e-37 5XD6-A nrPDB 152 3e-37 3G2F-A nrPDB 148 3e-36 5AR8-A nrPDB 147 5e-36 3SV0-A nrPDB 147 6e-36 4TN6-A nrPDB 145 3e-35 5FQD-C nrPDB 143 1e-34 4LQP-A nrPDB 142 3e-34 4BTK-A nrPDB 142 3e-34 4NFN-A nrPDB 140 8e-34 5E8V-A nrPDB 140 9e-34 3VHK-A nrPDB 137 5e-33 5VC6-A nrPDB 137 8e-33 2QLU-A nrPDB 135 3e-32 4RT7-A nrPDB 131 5e-31 5L2Q-C nrPDB 130 8e-31 4BTF-A nrPDB 130 9e-31 4M69-B nrPDB 130 9e-31 5X1R-A nrPDB 130 1e-30 5J0A-A nrPDB 130 1e-30 4XHH-A nrPDB 125 2e-29 4XHL-A nrPDB 124 6e-29 4JRN-A nrPDB 123 1e-28 1CSN-A nrPDB 122 2e-28 5OAT-A nrPDB 120 8e-28 2PZI-A nrPDB 116 2e-26 4Y12-A nrPDB 115 2e-26 5CLR-A nrPDB 86 3e-17 4CI6-B nrPDB 66 2e-11 Sequences not found previously or not previously below threshold: 3AOX-A nrPDB 175 3e-44 4YFF-A nrPDB 173 1e-43 2Y4I-B nrPDB 137 9e-33 6BFN-A nrPDB 136 2e-32 5X18-A nrPDB 130 6e-31 2CHL-A nrPDB 130 1e-30 4MWI-A nrPDB 129 2e-30 5VDK-A nrPDB 125 4e-29 5M07-A nrPDB 120 1e-27 4NT4-A nrPDB 120 1e-27 2CMW-A nrPDB 119 2e-27 2C47-A nrPDB 119 2e-27 5CEK-A nrPDB 108 3e-24 6DC0-A nrPDB 108 4e-24 3REP-A nrPDB 105 3e-23 5USZ-A nrPDB 103 9e-23 6EQI-C nrPDB 103 1e-22 4L00-A nrPDB 100 1e-21 5UV4-A nrPDB 100 1e-21 4L68-A nrPDB 97 2e-20 6J6I-B nrPDB 94 1e-19 5C01-A nrPDB 89 2e-18 4WOV-A nrPDB 89 2e-18 4I94-A nrPDB 87 1e-17 2RSV-A nrPDB 86 2e-17 2LAV-A nrPDB 85 5e-17 5UU1-A nrPDB 83 2e-16 5DMZ-A nrPDB 79 3e-15 4IX6-A nrPDB 78 8e-15 4OAU-C nrPDB 70 1e-12 6G4J-A nrPDB 69 3e-12 4O1O-A nrPDB 69 4e-12 2JII-A nrPDB 61 9e-10 3ENH-A nrPDB 59 3e-09 6BHC-A nrPDB 59 4e-09 6M7Z-A nrPDB 58 4e-09 4AZW-A nrPDB 58 5e-09 4AZV-A nrPDB 58 5e-09 6EAS-A nrPDB 56 3e-08 5GZA-A nrPDB 55 4e-08 6EWX-A nrPDB 54 8e-08 5GZ9-A nrPDB 53 2e-07 4CYJ-A nrPDB 50 1e-06 6G38-A nrPDB 50 2e-06 5VE6-A nrPDB 49 3e-06 3Q60-A nrPDB 48 5e-06 3BYV-A nrPDB 48 8e-06 4WWA-A nrPDB 48 9e-06 4BWP-A nrPDB 45 7e-05 6R5K-O nrPDB 44 8e-05 2W1Z-A nrPDB 44 1e-04 4XR7-L nrPDB 43 2e-04 3DZO-A nrPDB 42 4e-04 1TQM-A nrPDB 41 7e-04 6G18-v nrPDB 38 0.005 6FAI-l nrPDB 38 0.008 5YK0-A nrPDB 38 0.009 4BVU-A nrPDB 37 0.010 6FDN-A nrPDB 37 0.011 4CZY-B nrPDB 36 0.032 4ESA-B nrPDB 34 0.094 6EF6-A nrPDB 34 0.10 6CCZ-A nrPDB 34 0.11 >5AWM-A nrPDB Length = 394 Score = 541 bits (1395), Expect = e-154, Method: Composition-based stats. Identities = 372/372 (100%), Positives = 372/372 (100%) Query: 1 MTTAQHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQ 60 MTTAQHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQ Sbjct: 23 MTTAQHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQ 82 Query: 61 NVTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMD 120 NVTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMD Sbjct: 83 NVTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMD 142 Query: 121 LDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMM 180 LDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMM Sbjct: 143 LDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMM 202 Query: 181 TPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLG 240 TPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLG Sbjct: 203 TPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLG 262 Query: 241 TPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKM 300 TPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKM Sbjct: 263 TPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKM 322 Query: 301 LVIDPEQRISVDEALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYEEVM 360 LVIDPEQRISVDEALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYEEVM Sbjct: 323 LVIDPEQRISVDEALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYEEVM 382 Query: 361 DYEAHNTNNRTR 372 DYEAHNTNNRTR Sbjct: 383 DYEAHNTNNRTR 394 >1JNK-A nrPDB Length = 423 Score = 492 bits (1267), Expect = e-139, Method: Composition-based stats. Identities = 282/371 (76%), Positives = 319/371 (85%), Gaps = 1/371 (0%) Query: 2 TTAQHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQN 61 + +Q Y+VEVGD+ FT+ RY NL+PIGSGAQGIVCAAYD + +NVAIKKLSRPFQN Sbjct: 42 SKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQN 101 Query: 62 VTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDL 121 THAKRAYRE LMK VNHKNII LLN FTPQ+ LEEFQDVYLVMELMDANLCQVIQM+L Sbjct: 102 QTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMEL 161 Query: 122 DHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMT 181 DH+RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK+DCTLKILDFGLARTAGT+FMMT Sbjct: 162 DHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMT 221 Query: 182 PYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGT 241 PYVVTRYYRAPEVILGMGY ENVDIWSVGCIMGEM+R +LFPG D+IDQWNK+IEQLGT Sbjct: 222 PYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGT 281 Query: 242 PSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKML 301 P P FM++LQPTVRNYVENRP+Y G +F +LFPD LFP D+ N + + AR+LLSKML Sbjct: 282 PCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKAS-QARDLLSKML 340 Query: 302 VIDPEQRISVDEALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYEEVMD 361 VIDP +RISVD+AL+H YINVWYD EV+AP P+ YD +DEREHT+E+WKELIY+EVM+ Sbjct: 341 VIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMN 400 Query: 362 YEAHNTNNRTR 372 E N + Sbjct: 401 SEEKTKNGVVK 411 >2XS0-A nrPDB Length = 386 Score = 487 bits (1255), Expect = e-138, Method: Composition-based stats. Identities = 285/371 (76%), Positives = 321/371 (86%), Gaps = 1/371 (0%) Query: 2 TTAQHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQN 61 + + Y+VE+GD+ FT+ RY NL+PIGSGAQGIVCAAYD I ++NVAIKKLSRPFQN Sbjct: 6 SKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQN 65 Query: 62 VTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDL 121 THAKRAYRE LMK VNHKNIIGLLN FTPQ++LEEFQDVY+VMELMDANLCQVIQM+L Sbjct: 66 QTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMEL 125 Query: 122 DHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMT 181 DH+RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK+DCTLKILDFGLARTAGT+FMM Sbjct: 126 DHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMV 185 Query: 182 PYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGT 241 P+VVTRYYRAPEVILGMGY ENVDIWSVGCIMGEMI+GGVLFPGTDHIDQWNK+IEQLGT Sbjct: 186 PFVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGT 245 Query: 242 PSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKML 301 P P FM++LQPTVR YVENRP+Y GYSF++LFPD LFP D+ N + + AR+LLSKML Sbjct: 246 PCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKAS-QARDLLSKML 304 Query: 302 VIDPEQRISVDEALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYEEVMD 361 VID +RISVDEAL+H YINVWYD E +AP P+ D +DEREHT+E+WKELIY+EVMD Sbjct: 305 VIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMD 364 Query: 362 YEAHNTNNRTR 372 E N R Sbjct: 365 LEERTKNGVIR 375 >3E7O-A nrPDB Length = 360 Score = 464 bits (1194), Expect = e-131, Method: Composition-based stats. Identities = 268/357 (75%), Positives = 307/357 (85%), Gaps = 1/357 (0%) Query: 5 QHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTH 64 Q Y+V+V D+ FT+ RY L+PIGSGAQGIVCAA+DT+ NVA+KKLSRPFQN TH Sbjct: 5 DSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTH 64 Query: 65 AKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHD 124 AKRAYRE L+K VNHKNII LLN FTPQ+ LEEFQDVYLVMELMDANLCQVI M+LDH+ Sbjct: 65 AKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHE 124 Query: 125 RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYV 184 RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK+DCTLKILDFGLARTA T FMMTPYV Sbjct: 125 RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTASTNFMMTPYV 184 Query: 185 VTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSP 244 VTRYYRAPEVILGMGY ENVDIWSVGCIMGE+++G V+F GTDHIDQWNK+IEQLGTPS Sbjct: 185 VTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGSVIFQGTDHIDQWNKVIEQLGTPSA 244 Query: 245 SFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVID 304 FM LQPTVRNYVENRP Y G +F+ LFPD +FP+++ ++ + + AR+LLSKMLVID Sbjct: 245 EFMAALQPTVRNYVENRPAYPGIAFEELFPDWIFPSESERDKIKTS-QARDLLSKMLVID 303 Query: 305 PEQRISVDEALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYEEVMD 361 P++RISVDEAL+H YI VWYD E +AP P+ YD ++EREH +E+WKELIY+EVMD Sbjct: 304 PDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMD 360 >3FI2-A nrPDB Length = 353 Score = 451 bits (1161), Expect = e-127, Method: Composition-based stats. Identities = 273/362 (75%), Positives = 306/362 (84%), Gaps = 12/362 (3%) Query: 2 TTAQHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQN 61 + +Q Y+VEVGD+ FT+ RY NL+PIGSGAQGIVCAAYD + +NVAIKKLSRPFQN Sbjct: 4 SKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQN 63 Query: 62 VTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDL 121 THAKRAYRE LMK VNHKNII LLN FTPQ+ LEEFQDVYLVMELMDANLCQVIQM+L Sbjct: 64 QTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMEL 123 Query: 122 DHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMT 181 DH+RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK+DCTLKILDFGLARTAGT+FMMT Sbjct: 124 DHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMT 183 Query: 182 PYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGT 241 PYVVTRYYRAPEVILGMGY ENVDIWSVGCIMGEM+R +LFPG D+IDQWNK+IEQLGT Sbjct: 184 PYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGT 243 Query: 242 PSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKML 301 P P FM++LQPTVRNYVENRP+Y G +F +LFPD LFP D+ N + + AR+LLSKML Sbjct: 244 PCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKAS-QARDLLSKML 302 Query: 302 VIDPEQRISVDEALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYEEVMD 361 VIDP +RISVD+AL+H YINVWY DEREHT+E+WKELIY+EVM+ Sbjct: 303 VIDPAKRISVDDALQHPYINVWYXXXXX-----------XDEREHTIEEWKELIYKEVMN 351 Query: 362 YE 363 E Sbjct: 352 SE 353 >4EWQ-A nrPDB Length = 383 Score = 385 bits (990), Expect = e-107, Method: Composition-based stats. Identities = 170/359 (47%), Positives = 234/359 (65%), Gaps = 20/359 (5%) Query: 7 QHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAK 66 Y E+ T + + RY NL P+GSGA G VCAA+DT T VA+KKLSRPFQ++ HAK Sbjct: 30 TFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAK 89 Query: 67 RAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQ-MDLDHDR 125 R YRE +L+K + H+N+IGLL+ FTP R+LEEF DVYLV LM A+L +++ L D Sbjct: 90 RTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDH 149 Query: 126 MSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVV 185 + +L+YQ+L G+K++HSA IIHRDLKPSN+ V DC LKILDFGLAR T MT YV Sbjct: 150 VQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDEMTGYVA 207 Query: 186 TRYYRAPEVILG-MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSP 244 TR+YRAPE++L M Y + VDIWSVGCIM E++ G LFPGTDHIDQ I+ +GTP Sbjct: 208 TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGA 267 Query: 245 SFMQRL-QPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVI 303 ++++ + RNY+++ + +F +F A +LL KMLV+ Sbjct: 268 ELLKKISSESARNYIQSLTQMPKMNFANVF-------------IGANPLAVDLLEKMLVL 314 Query: 304 DPEQRISVDEALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYEEVMDY 362 D ++RI+ +AL H Y ++D + D P +PYD S + R+ +++WK L Y+EV+ + Sbjct: 315 DSDKRITAAQALAHAYFAQYHDPD--DEPVADPYDQSFESRDLLIDEWKSLTYDEVISF 371 >3OHT-A nrPDB Length = 389 Score = 384 bits (987), Expect = e-107, Method: Composition-based stats. Identities = 171/360 (47%), Positives = 230/360 (63%), Gaps = 20/360 (5%) Query: 7 QHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAK 66 Y E+ T + + RY L P+GSGA G VC++YD + +A+KKLSRPFQ++ HAK Sbjct: 36 TFYRQELNKTIWEVPERYQTLSPVGSGAYGSVCSSYDVKSGLKIAVKKLSRPFQSIIHAK 95 Query: 67 RAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQ-MDLDHDR 125 R YRE +L+K + H+N+IGLL+ FTP +LEEF DVYLV LM A+L +++ L D Sbjct: 96 RTYRELRLLKHMKHENVIGLLDVFTPATSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDH 155 Query: 126 MSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVV 185 + +L+YQ+L G+K++HSA IIHRDLKPSN+ V DC LKILDFGLAR T MT YV Sbjct: 156 VQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDEMTGYVA 213 Query: 186 TRYYRAPEVILG-MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSP 244 TR+YRAPE++L M Y VDIWSVGCIM E++ G LFPGTDHI+Q +I+ GTP Sbjct: 214 TRWYRAPEIMLNWMHYNMTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPA 273 Query: 245 SFMQRLQP-TVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVI 303 S + R+ RNY+ + P+ +F +F A +LL KMLV+ Sbjct: 274 SVISRMPSHEARNYINSLPQMPKRNFADVF-------------IGANPLAVDLLEKMLVL 320 Query: 304 DPEQRISVDEALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYEEVMDYE 363 D ++RI+ EAL H Y + ++D + D P EPYD S + R+ +E+WK L YEEV +E Sbjct: 321 DTDKRITASEALAHPYFSQYHDPD--DEPESEPYDQSFESRQLEIEEWKRLTYEEVCSFE 378 >3GC9-A nrPDB Length = 370 Score = 383 bits (984), Expect = e-107, Method: Composition-based stats. Identities = 170/365 (46%), Positives = 240/365 (65%), Gaps = 20/365 (5%) Query: 1 MTTAQHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQ 60 M+ + Y E+ T + + R LRP+GSGA G VC+AYD +Q VA+KKLSRPFQ Sbjct: 7 MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQ 66 Query: 61 NVTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMD 120 ++ HA+R YRE +L+K + H+N+IGLL+ FTP ++E+F +VYLV LM A+L +++ Sbjct: 67 SLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKSQ 126 Query: 121 -LDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFM 179 L + + +L+YQ+L G+K++HSAGIIHRDLKPSN+ V D L+ILDFGLAR A Sbjct: 127 ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDSELRILDFGLARQADE--E 184 Query: 180 MTPYVVTRYYRAPEVILG-MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQ 238 MT YV TR+YRAPE++L M Y + VDIWSVGCIM E+++G LFPG+D+IDQ +I+E Sbjct: 185 MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEV 244 Query: 239 LGTPSPSFMQRLQPT-VRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLL 297 +GTPSP + ++ R Y+++ P +F R A +LL Sbjct: 245 VGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIF-------------RGANPLAIDLL 291 Query: 298 SKMLVIDPEQRISVDEALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYE 357 +MLV+D +QR+S EAL H Y + ++D E D P EPYD SV+ +E T+E+WKEL Y+ Sbjct: 292 GRMLVLDSDQRVSAAEALAHAYFSQYHDPE--DEPEAEPYDESVEAKERTLEEWKELTYQ 349 Query: 358 EVMDY 362 EV+ + Sbjct: 350 EVLSF 354 >1CM8-A nrPDB Length = 367 Score = 383 bits (983), Expect = e-107, Method: Composition-based stats. Identities = 173/367 (47%), Positives = 234/367 (63%), Gaps = 20/367 (5%) Query: 4 AQHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVT 63 A+ Y EV T + + + Y +L+P+GSGA G VC+A D T VAIKKL RPFQ+ Sbjct: 7 ARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSEL 66 Query: 64 HAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQ-MDLD 122 AKRAYRE +L+K + H+N+IGLL+ FTP L++F D YLVM M +L ++++ L Sbjct: 67 FAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLG 126 Query: 123 HDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTP 182 DR+ +L+YQML G++++H+AGIIHRDLKP N+ V DC LKILDFGLAR A + MT Sbjct: 127 EDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS--EMTG 184 Query: 183 YVVTRYYRAPEVILG-MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGT 241 YVVTR+YRAPEVIL M YT+ VDIWSVGCIM EMI G LF G+DH+DQ +I++ GT Sbjct: 185 YVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGT 244 Query: 242 PSPSFMQRLQ-PTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKM 300 P F+QRLQ +NY++ P F + + + A NLL KM Sbjct: 245 PPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNA-------------SPLAVNLLEKM 291 Query: 301 LVIDPEQRISVDEALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYEEVM 360 LV+D EQR++ EAL H Y +D E D P + YD S D+ + T+++WK + Y+EV+ Sbjct: 292 LVLDAEQRVTAGEALAHPYFESLHDTE--DEPQVQKYDDSFDDVDRTLDEWKRVTYKEVL 349 Query: 361 DYEAHNT 367 ++ Sbjct: 350 SFKPPRQ 356 >4MYG-A nrPDB Length = 372 Score = 376 bits (965), Expect = e-104, Method: Composition-based stats. Identities = 159/358 (44%), Positives = 231/358 (64%), Gaps = 18/358 (5%) Query: 7 QHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAK 66 Y +V T + + Y++ +GSGA G VC+A D + + VAIKKLSRPFQ+ AK Sbjct: 28 GFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAK 87 Query: 67 RAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRM 126 RAYRE L+K + H+N+IGLL+ FTP +L F D YLVM M +L +++ M+ +++ Sbjct: 88 RAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKI 147 Query: 127 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVT 186 YL+YQML G+K++HSAG++HRDLKP N+ V DC LKILDFGLAR A MT YVVT Sbjct: 148 QYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADA--EMTGYVVT 205 Query: 187 RYYRAPEVILG-MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPS 245 R+YRAPEVIL M Y + VDIWSVGCIM EM+ G LF G D++DQ +I++ G P Sbjct: 206 RWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTE 265 Query: 246 FMQRLQ-PTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVID 304 F+Q+L ++Y+++ P+ F +LFP R + A +LL KML +D Sbjct: 266 FVQKLNDKAAKSYIQSLPQTPRKDFTQLFP-------------RASPQAADLLEKMLELD 312 Query: 305 PEQRISVDEALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYEEVMDY 362 ++R++ +AL H + + D EE + A +P+D S++ + TV++WK+ IY+E++++ Sbjct: 313 VDKRLTAAQALTHPFFEPFRDPEE-ETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNF 369 >4IC8-A nrPDB Length = 442 Score = 354 bits (909), Expect = 3e-98, Method: Composition-based stats. Identities = 142/365 (38%), Positives = 211/365 (57%), Gaps = 23/365 (6%) Query: 15 DTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKL 74 D F + Y + IG+GA G+V +A +T Q VAIKK+ F VT+AKR RE K+ Sbjct: 48 DVTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKI 107 Query: 75 MKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQM--DLDHDRMSYLLYQ 132 +K H NII + + P EF+ VY+V++LM+++L Q+I L + + Y LYQ Sbjct: 108 LKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQ 167 Query: 133 MLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLAR-----TAGTTFMMTPYVVTR 187 +L G+K++HSA +IHRDLKPSN++V +C LKI DFG+AR A + MT YV TR Sbjct: 168 LLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATR 227 Query: 188 YYRAPEVILGMG-YTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSF 246 +YRAPE++L + YT+ +D+WSVGCI GEM+ LFPG +++ Q I+ LGTPSP+ Sbjct: 228 WYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAV 287 Query: 247 MQRLQ-PTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDP 305 +Q + VR Y+++ P ++ ++P A +LL +ML +P Sbjct: 288 IQAVGAERVRAYIQSLPPRQPVPWETVYPGA-------------DRQALSLLGRMLRFEP 334 Query: 306 EQRISVDEALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYEEVMDYEAH 365 RIS AL+H ++ ++D ++ AP P+D + D T E+ KE I E+ D+ A Sbjct: 335 SARISAAAALRHPFLAKYHDPDDEPDCAP-PFDFAFDREALTRERIKEAIVAEIEDFHAR 393 Query: 366 NTNNR 370 R Sbjct: 394 REGIR 398 >4ZSG-A nrPDB Length = 347 Score = 344 bits (882), Expect = 4e-95, Method: Composition-based stats. Identities = 140/361 (38%), Positives = 209/361 (57%), Gaps = 23/361 (6%) Query: 16 TNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLM 75 F + Y + IG+GA G+V +A +T Q VAIKK+ F VT+AKR RE K++ Sbjct: 1 VTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKIL 60 Query: 76 KLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQM--DLDHDRMSYLLYQM 133 K H NII + + P EF+ VY+V++LM+++L Q+I L + + Y LYQ+ Sbjct: 61 KHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQL 120 Query: 134 LCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLAR-----TAGTTFMMTPYVVTRY 188 L G+K++HSA +IHRDLKPSN++V +C LKI DFG+AR A + MT YV TR+ Sbjct: 121 LRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRW 180 Query: 189 YRAPEVILGMG-YTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFM 247 YRAPE++L + YT+ +D+WSVGCI GEM+ LFPG +++ Q I+ LGTPSP+ + Sbjct: 181 YRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVI 240 Query: 248 QRLQ-PTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPE 306 Q + VR Y+++ P ++ ++P A +LL +ML +P Sbjct: 241 QAVGAERVRAYIQSLPPRQPVPWETVYPGA-------------DRQALSLLGRMLRFEPS 287 Query: 307 QRISVDEALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYEEVMDYEAHN 366 RIS AL+H ++ ++D ++ AP P+D + D T E+ KE I E+ D+ A Sbjct: 288 ARISAAAALRHPFLAKYHDPDDEPDCAP-PFDFAFDREALTRERIKEAIVAEIEDFHARR 346 Query: 367 T 367 Sbjct: 347 E 347 >5Z33-A nrPDB Length = 425 Score = 343 bits (881), Expect = 6e-95, Method: Composition-based stats. Identities = 143/370 (38%), Positives = 208/370 (56%), Gaps = 29/370 (7%) Query: 6 HQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHA 65 +V + +F + RY + +G GA GIVCAA + T + VAIKK++ F A Sbjct: 15 QGRKIFKVFNQDFIVDERYTVTKELGQGAYGIVCAAVNNQTSEGVAIKKVTNVFSKKILA 74 Query: 66 KRAYREFKLMKLVN-HKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQM--DLD 122 KRA RE KL++ H+NI L + P+ + F + YL ELM+ +L +I+ L Sbjct: 75 KRALREIKLLQHFRGHRNITCLYDMDIPRPD--NFNETYLYEELMECDLAAIIRSGQPLT 132 Query: 123 HDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLAR-----TAGTT 177 +YQ+LCG+K++HSA ++HRDLKP N++V ADC LKI DFGLAR Sbjct: 133 DAHFQSFIYQILCGLKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSVDPEENA 192 Query: 178 FMMTPYVVTRYYRAPEV-ILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKII 236 MT YV TR+YRAPE+ + YT+ +D+WSVGCI+ E++ G F G D++DQ N+I+ Sbjct: 193 GYMTEYVATRWYRAPEIMLSFQSYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQIL 252 Query: 237 EQLGTPSPSFMQRL-QPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARN 295 LGTP+ + R+ P + YV N P F LFP+ DA + Sbjct: 253 HILGTPNEETLSRIGSPRAQEYVRNLPFMAKKPFPTLFPNA-------------NPDALD 299 Query: 296 LLSKMLVIDPEQRISVDEALKHEYINVWYDA-EEVDAPAPEPYDHSVDEREHTVEQWKEL 354 LL +ML DP RISV++AL+H Y+++W+DA +E D P +D V E V + +++ Sbjct: 300 LLDRMLAFDPSSRISVEQALEHPYLHIWHDASDEPDCPTTFNFDFEVVE---DVGEMRKM 356 Query: 355 IYEEVMDYEA 364 I +EV + Sbjct: 357 ILDEVYRFRQ 366 >6DTL-A nrPDB Length = 364 Score = 343 bits (879), Expect = 1e-94, Method: Composition-based stats. Identities = 139/362 (38%), Positives = 207/362 (57%), Gaps = 19/362 (5%) Query: 5 QHQHYTVEVGDTNFTIHSRYIN-LRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVT 63 + + F + ++Y + PIG GA GIVC+A ++ T ++VAIKK++ F N Sbjct: 12 GGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKI 71 Query: 64 HAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMD--L 121 AKR RE KL++ ++H+NI+ + + P F DVY+ ELMD +L Q+I+ + L Sbjct: 72 DAKRTLREIKLLRHMDHENIVAIRDIIPPPLR-NAFNDVYIAYELMDTDLHQIIRSNQAL 130 Query: 122 DHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMT 181 + Y LYQ+L G+K++HSA ++HRDLKPSN+++ A+C LKI DFGLAR + MT Sbjct: 131 SEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMT 190 Query: 182 PYVVTRYYRAPEVILG-MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLG 240 YVVTR+YRAPE++L YT +D+WSVGCI E++ LFPG DH+ Q ++E +G Sbjct: 191 EYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIG 250 Query: 241 TPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKM 300 TPS ++ L + Y+ P Y S FP A +L+ KM Sbjct: 251 TPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPT-------------VHPLAIDLIEKM 297 Query: 301 LVIDPEQRISVDEALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYEEVM 360 L DP +RI+V +AL H Y+N +D + + P++ + + EQ KELIY E + Sbjct: 298 LTFDPRRRITVLDALAHPYLNSLHDISD-EPECTIPFNFDFENHALSEEQMKELIYREAL 356 Query: 361 DY 362 + Sbjct: 357 AF 358 >4QTB-A nrPDB Length = 380 Score = 342 bits (878), Expect = 1e-94, Method: Composition-based stats. Identities = 138/353 (39%), Positives = 218/353 (61%), Gaps = 23/353 (6%) Query: 18 FTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKL 77 F + RY L+ IG GA G+V +AYD + + VAIKK+S PF++ T+ +R RE +++ Sbjct: 37 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLR 95 Query: 78 VNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMD-LDHDRMSYLLYQMLCG 136 H+N+IG+ + LE +DVY+V +LM+ +L ++++ L +D + Y LYQ+L G Sbjct: 96 FRHENVIGIRDI-LRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRG 154 Query: 137 IKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTA----GTTFMMTPYVVTRYYRAP 192 +K++HSA ++HRDLKPSN+++ C LKI DFGLAR A T +T YV TR+YRAP Sbjct: 155 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 214 Query: 193 EV-ILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQR-L 250 E+ + GYT+++DIWSVGCI+ EM+ +FPG ++DQ N I+ LG+PS + + Sbjct: 215 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 274 Query: 251 QPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRIS 310 RNY+++ P T ++ +LFP + S A +LL +ML +P +RI+ Sbjct: 275 NMKARNYLQSLPSKTKVAWAKLFP-------------KSDSKALDLLDRMLTFNPNKRIT 321 Query: 311 VDEALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYEEVMDYE 363 V+EAL H Y+ +YD + A EP+ +++ + E+ KELI++E ++ Sbjct: 322 VEEALAHPYLEQYYDPTDEPV-AEEPFTFAMELDDLPKERLKELIFQETARFQ 373 >5NGU-A nrPDB Length = 381 Score = 336 bits (863), Expect = 7e-93, Method: Composition-based stats. Identities = 144/354 (40%), Positives = 217/354 (61%), Gaps = 25/354 (7%) Query: 18 FTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKL 77 F + RY NL IG GA G+VC+AYD + + VAIKK+S PF++ T+ +R RE K++ Sbjct: 38 FDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKIS-PFEHQTYCQRTLREIKILLR 96 Query: 78 VNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMD-LDHDRMSYLLYQMLCG 136 H+NIIG+ + +E+ +DVY+V +LM+ +L ++++ L +D + Y LYQ+L G Sbjct: 97 FRHENIIGINDIIR-APTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRG 155 Query: 137 IKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTF----MMTPYVVTRYYRAP 192 +K++HSA ++HRDLKPSN+++ C LKI DFGLAR A +T YV TR+YRAP Sbjct: 156 LKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAP 215 Query: 193 EV-ILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQR-L 250 E+ + GYT+++DIWSVGCI+ EM+ +FPG ++DQ N I+ LG+PS + + Sbjct: 216 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 275 Query: 251 QPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRIS 310 RNY+ + P ++RLFP+ S A +LL KML +P +RI Sbjct: 276 NLKARNYLLSLPHKNKVPWNRLFPNA-------------DSKALDLLDKMLTFNPHKRIE 322 Query: 311 VDEALKHEYINVWYDA-EEVDAPAPEPYDHSVDEREHTVEQWKELIYEEVMDYE 363 V++AL H Y+ +YD +E A AP +D +D+ E+ KELI+EE ++ Sbjct: 323 VEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPK--EKLKELIFEETARFQ 374 >2F9G-A nrPDB Length = 353 Score = 330 bits (845), Expect = 8e-91, Method: Composition-based stats. Identities = 130/364 (35%), Positives = 188/364 (51%), Gaps = 37/364 (10%) Query: 18 FTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKL 77 + I S + +G GA G+VC+A T + VAIKK+ PF A R RE K++K Sbjct: 7 YNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIE-PFDKPLFALRTLREIKILKH 65 Query: 78 VNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMD-LDHDRMSYLLYQMLCG 136 H+NII + N + E F +VY++ ELM +L +VI L D + Y +YQ L Sbjct: 66 FKHENIITIFNI-QRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRA 124 Query: 137 IKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFM-----------MTPYVV 185 +K LH + +IHRDLKPSN+++ ++C LK+ DFGLAR + MT YV Sbjct: 125 VKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVA 184 Query: 186 TRYYRAPEV-ILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSP 244 TR+YRAPEV + Y+ +D+WS GCI+ E+ +FPG D+ Q I +GTP Sbjct: 185 TRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHS 244 Query: 245 SFMQRL--QPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLV 302 R P R Y+++ P Y +++FP R +LL +MLV Sbjct: 245 DNDLRCIESPRAREYIKSLPMYPAAPLEKMFP-------------RVNPKGIDLLQRMLV 291 Query: 303 IDPEQRISVDEALKHEYINVWYDAEEVDAPAPEPYDHSVDEREH-----TVEQWKELIYE 357 DP +RI+ EAL+H Y+ ++D D P EP S E +H T + K+LI+ Sbjct: 292 FDPAKRITAKEALEHPYLQTYHDPN--DEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWN 349 Query: 358 EVMD 361 E+ Sbjct: 350 EIFS 353 >3OZ6-A nrPDB Length = 388 Score = 323 bits (828), Expect = 7e-89, Method: Composition-based stats. Identities = 115/380 (30%), Positives = 206/380 (54%), Gaps = 33/380 (8%) Query: 14 GDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFK 73 G + + +Y ++ +G GA GIV + D T + VA+KK+ FQN T A+R +RE Sbjct: 1 GRVDRHVLRKYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIFDAFQNSTDAQRTFREIM 60 Query: 74 LMKLVN-HKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHD-RMSYLLY 131 ++ ++ H+NI+ LLN + +DVYLV + M+ +L VI+ ++ Y++Y Sbjct: 61 ILTELSGHENIVNLLNVLRADND----RDVYLVFDYMETDLHAVIRANILEPVHKQYVVY 116 Query: 132 QMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTA----------------- 174 Q++ IK+LHS G++HRD+KPSNI++ A+C +K+ DFGL+R+ Sbjct: 117 QLIKVIKYLHSGGLLHRDMKPSNILLNAECHVKVADFGLSRSFVNIRRVTNNIPLSINEN 176 Query: 175 -----GTTFMMTPYVVTRYYRAPEVILGM-GYTENVDIWSVGCIMGEMIRGGVLFPGTDH 228 ++T YV TR+YRAPE++LG YT+ +D+WS+GCI+GE++ G +FPG+ Sbjct: 177 TENFDDDQPILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGKPIFPGSST 236 Query: 229 IDQWNKIIEQLGTPSPSFMQRLQ----PTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQ 284 ++Q +II + PS ++ +Q T+ ++ + + +F Sbjct: 237 MNQLERIIGVIDFPSNEDVESIQSPFAKTMIESLKEKVEIRQSNKRDIFTKWKNLLLKIN 296 Query: 285 NSRRKASDARNLLSKMLVIDPEQRISVDEALKHEYINVWYDAEEVDAPAPEPYDHSVDER 344 +A +LL K+L +P +RIS ++ALKH +++++++ E D Sbjct: 297 PKADCNEEALDLLDKLLQFNPNKRISANDALKHPFVSIFHNPNEEPNCDHIITIPINDNV 356 Query: 345 EHTVEQWKELIYEEVMDYEA 364 +H+++ ++ L+Y E+ + Sbjct: 357 KHSIDDYRNLVYSEISRRKR 376 >4O2Z-A nrPDB Length = 377 Score = 315 bits (806), Expect = 3e-86, Method: Composition-based stats. Identities = 119/360 (33%), Positives = 187/360 (51%), Gaps = 20/360 (5%) Query: 8 HYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKR 67 V + F + S+Y L+ +G GA GI C+ D T + V+IKK F++V KR Sbjct: 31 FKVYNVSGSPFEVPSKYTLLKILGMGAYGIACSCLDGDTGEKVSIKKCRDVFRDVEDGKR 90 Query: 68 AYREFKLMKLVNHKNIIGLLNAFTP-QRNLEEFQDVYLVMELMDANLCQVIQMD--LDHD 124 RE +M+ +H+N++ ++N P +R F+DVY+V LMD ++ V++ L+ Sbjct: 91 VLREIDMMRFFHHENLLNVVNILPPLKREYHSFEDVYVVTPLMDVDMNVVLRSRQVLEES 150 Query: 125 RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAG-TTFMMTPY 183 M Y +YQ+L G+K+LHSA + HRDLKP+N+V C LKI+DFGL+R+ +T Y Sbjct: 151 HMQYFVYQILRGLKYLHSANVAHRDLKPANLVTNISCELKIIDFGLSRSVDVPYSELTDY 210 Query: 184 VVTRYYRAPEVIL-GMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTP 242 V+TR+YR PE++L Y+ VDIWSVGCI EM +FPG + +DQ I + +G P Sbjct: 211 VITRWYRPPELLLENTNYSTAVDIWSVGCIFAEMYNRKPVFPGRNTMDQLRMIAQHIGKP 270 Query: 243 SPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLV 302 S ++ PDG ++ + LSKM Sbjct: 271 PASIVE--------------HREALEKLNELPDGSLNIPKLVPGLAGNTEGIDFLSKMWT 316 Query: 303 IDPEQRISVDEALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYEEVMDY 362 +DP +R + + L H Y+ +D EE + P P+ + + V + + + +++DY Sbjct: 317 LDPSKRPTAADMLAHPYLAHLHD-EEDEPTCPCPFLWAHESTPMGVSELRRAFWADIVDY 375 >4QNY-A nrPDB Length = 354 Score = 312 bits (800), Expect = 2e-85, Method: Composition-based stats. Identities = 123/362 (33%), Positives = 197/362 (54%), Gaps = 27/362 (7%) Query: 11 VEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYD-TITQQNVAIKKLSRP-FQNVTHAKRA 68 E+ + RY+ R IG+G+ G+V A D + VA+K++++ F+ V AKR Sbjct: 9 AELQAEVCRLDDRYLLERIIGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFEEVILAKRI 68 Query: 69 YREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQM--DLDHDRM 126 RE KL+ N NIIGL N TP+ E F Y+VM++M+ +L QV++ +L + Sbjct: 69 LREIKLLAHFNDDNIIGLRNILTPEDP-ENFDHFYIVMDIMETDLKQVLRSGQELTEAHI 127 Query: 127 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGT-TFMMTPYVV 185 + +YQ L + +HSAG+IHRD+ P+NI+V +C LKI DFGLA+ MT YV Sbjct: 128 QFFIYQALRALHIIHSAGVIHRDITPANILVNTNCDLKICDFGLAKEENDQGEYMTDYVT 187 Query: 186 TRYYRAPE-VILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSP 244 R+YRAPE V+ Y+ +D+W +GCI+GE++ LF G D ++Q +KI++ +GTPS Sbjct: 188 MRWYRAPELVMEDKDYSAQIDVWGIGCILGELLGSRPLFQGKDRVNQLDKIVDVIGTPSE 247 Query: 245 SFMQRL-QPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVI 303 + + + Y++ + + + +P + +A +LL MLV Sbjct: 248 EDINSVGSSAAQKYLKKKSHRPQADWRQRYPTA-------------SPEALDLLRHMLVF 294 Query: 304 DPEQRISVDEALKHEYINVWYDAEEVDAPAPEPYD-HSVDERE-HTVEQWKELIYEEVMD 361 +P++RI+V +A++H ++ +D DA Y DE E T+ K IYEE + Sbjct: 295 NPKRRITVLQAMRHPFLEQLHD----DADDNLSYALFRFDENEQKTIVDVKRAIYEESVK 350 Query: 362 YE 363 + Sbjct: 351 FH 352 >3NIZ-A nrPDB Length = 311 Score = 310 bits (794), Expect = 7e-85, Method: Composition-based stats. Identities = 107/318 (33%), Positives = 157/318 (49%), Gaps = 28/318 (8%) Query: 14 GDTNFTIH---SRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYR 70 G N +Y L +G G G+V A D+ + VA+K++ ++ A R Sbjct: 10 GRENLYFQGLMEKYQKLEKVGEGTYGVVYKAKDSQ-GRIVALKRIRLDAEDEGIPSTAIR 68 Query: 71 EFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVI---QMDLDHDRMS 127 E L+K ++H NI+ L++ +R L LV E M+ +L +V+ + L ++ Sbjct: 69 EISLLKELHHPNIVSLIDVIHSERCLT------LVFEFMEKDLKKVLDENKTGLQDSQIK 122 Query: 128 YLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAG-TTFMMTPYVVT 186 LYQ+L G+ H H I+HRDLKP N+++ +D LK+ DFGLAR G T VVT Sbjct: 123 IYLYQLLRGVAHCHQHRILHRDLKPQNLLINSDGALKLADFGLARAFGIPVRSYTHEVVT 182 Query: 187 RYYRAPEVILG-MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPS 245 +YRAP+V++G Y+ +VDIWS+GCI EMI G LFPG DQ KI LGTP+P Sbjct: 183 LWYRAPDVLMGSKKYSTSVDIWSIGCIFAEMITGKPLFPGVTDDDQLPKIFSILGTPNPR 242 Query: 246 FMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDP 305 ++Q + + + P + +LLS ML DP Sbjct: 243 EWPQVQELPLWKQRTFQVFEKKPWSSIIPGFC-------------QEGIDLLSNMLCFDP 289 Query: 306 EQRISVDEALKHEYINVW 323 +RIS +A+ H Y Sbjct: 290 NKRISARDAMNHPYFKDL 307 >2BPM-A nrPDB Length = 309 Score = 310 bits (793), Expect = 9e-85, Method: Composition-based stats. Identities = 107/331 (32%), Positives = 159/331 (48%), Gaps = 36/331 (10%) Query: 22 SRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHK 81 + + IG G G+V A + +T + VA+KK+ + A RE L+K +NH Sbjct: 7 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 66 Query: 82 NIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQ----MDLDHDRMSYLLYQMLCGI 137 NI+ LL+ + L YLV E + +L + + + + L+Q+L G+ Sbjct: 67 NIVKLLDVIHTENKL------YLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGL 120 Query: 138 KHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAG-TTFMMTPYVVTRYYRAPEVIL 196 HS ++HRDLKP N+++ + +K+ DFGLAR G T VVT +YRAPE++L Sbjct: 121 AFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILL 180 Query: 197 GMG-YTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVR 255 G Y+ VDIWS+GCI EM+ LFPG IDQ +I LGTP + ++ Sbjct: 181 GCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVT-SMP 239 Query: 256 NYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEAL 315 +Y + P++ F ++ P D R+LLS+ML DP +RIS AL Sbjct: 240 DYKPSFPKWARQDFSKVVPP-------------LDEDGRSLLSQMLHYDPNKRISAKAAL 286 Query: 316 KHEYINVWYDAEEVDAPAPEPYDHSVDEREH 346 H + +P H ER H Sbjct: 287 AHPFFQD----------VTKPVPHLRLERPH 307 >6GU6-A nrPDB Length = 302 Score = 298 bits (764), Expect = 2e-81, Method: Composition-based stats. Identities = 101/309 (32%), Positives = 149/309 (48%), Gaps = 27/309 (8%) Query: 22 SRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHK 81 Y + IG G G+V T Q VA+KK+ + A RE L+K + H Sbjct: 7 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 66 Query: 82 NIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQM-----DLDHDRMSYLLYQMLCG 136 NI+ L + L + +YL+ E + +L + + +D + LYQ+L G Sbjct: 67 NIVSLQDV------LMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQG 120 Query: 137 IKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAG-TTFMMTPYVVTRYYRAPEVI 195 I HS ++HRDLKP N+++ T+K+ DFGLAR G + T VVT +YR+PEV+ Sbjct: 121 IVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVL 180 Query: 196 LGM-GYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTV 254 LG Y+ VDIWS+G I E+ LF G IDQ +I LGTP+ + ++ Sbjct: 181 LGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEV-ESL 239 Query: 255 RNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEA 314 ++Y P++ P + + + +LLSKML+ DP +RIS A Sbjct: 240 QDYKNTFPKWK-------------PGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMA 286 Query: 315 LKHEYINVW 323 L H Y N Sbjct: 287 LNHPYFNDL 295 >4AU8-A nrPDB Length = 296 Score = 294 bits (752), Expect = 5e-80, Method: Composition-based stats. Identities = 99/312 (31%), Positives = 147/312 (47%), Gaps = 26/312 (8%) Query: 21 HSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNH 80 +Y L IG G G V A + T + VA+K++ + A RE L+K + H Sbjct: 5 SQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 64 Query: 81 KNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQM---DLDHDRMSYLLYQMLCGI 137 KNI+ L + + L LV E D +L + DLD + + L+Q+L G+ Sbjct: 65 KNIVRLHDVLHSDKKLT------LVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGL 118 Query: 138 KHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAG-TTFMMTPYVVTRYYRAPEVIL 196 HS ++HRDLKP N+++ + LK+ DFGLAR G + VVT +YR P+V+ Sbjct: 119 GFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLF 178 Query: 197 GMG-YTENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTV 254 G Y+ ++D+WS GCI E+ G LFPG D DQ +I LGTP+ Sbjct: 179 GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQW------- 231 Query: 255 RNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEA 314 P T + +P + + R+LL +L +P QRIS +EA Sbjct: 232 -------PSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEA 284 Query: 315 LKHEYINVWYDA 326 L+H Y + + Sbjct: 285 LQHPYFSDFCPP 296 >1V0B-A nrPDB Length = 288 Score = 293 bits (751), Expect = 6e-80, Method: Composition-based stats. Identities = 102/306 (33%), Positives = 150/306 (49%), Gaps = 26/306 (8%) Query: 22 SRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHK 81 +Y L IG G G+V A + + A+KK+ ++ RE ++K + H Sbjct: 2 EKYHGLEKIGEGTYGVVYKAQNNY-GETFALKKIRLEKEDEGIPSTTIREISILKELKHS 60 Query: 82 NIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVI---QMDLDHDRMSYLLYQMLCGIK 138 NI+ L + ++ L LV E +D +L +++ + L+ L Q+L GI Sbjct: 61 NIVKLYDVIHTKKRL------VLVFEHLDQDLKKLLDVCEGGLESVTAKSFLLQLLNGIA 114 Query: 139 HLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAG-TTFMMTPYVVTRYYRAPEVILG 197 + H ++HRDLKP N+++ + LKI DFGLAR G T VVT +YRAP+V++G Sbjct: 115 YCHDRRVLHRDLKPQNLLINREGELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVLMG 174 Query: 198 -MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRN 256 Y+ +DIWSVGCI EM+ G LFPG DQ +I LGTP+ + P V Sbjct: 175 SKKYSTTIDIWSVGCIFAEMVNGAPLFPGVSEADQLMRIFRILGTPN----SKNWPNVTE 230 Query: 257 YVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALK 316 + P +T Y P + +LLSKML +DP QRI+ +AL+ Sbjct: 231 LPKYDPNFTVYE----------PLPWESFLKGLDESGIDLLSKMLKLDPNQRITAKQALE 280 Query: 317 HEYINV 322 H Y Sbjct: 281 HAYFKE 286 >4KRC-A nrPDB Length = 317 Score = 293 bits (749), Expect = 1e-79, Method: Composition-based stats. Identities = 97/315 (30%), Positives = 151/315 (47%), Gaps = 26/315 (8%) Query: 21 HSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNH 80 S++ L +G+G V + T VA+K++ + T A RE LMK + H Sbjct: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGT-PSTAIREISLMKELKH 62 Query: 81 KNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMD--------LDHDRMSYLLYQ 132 +NI+ L + + L LV E MD +L + + L+ + + Y +Q Sbjct: 63 ENIVRLYDVIHTENKLT------LVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQ 116 Query: 133 MLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAG-TTFMMTPYVVTRYYRA 191 +L G+ H I+HRDLKP N+++ LK+ DFGLAR G + VVT +YRA Sbjct: 117 LLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRA 176 Query: 192 PEVILG-MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRL 250 P+V++G Y+ ++DIWS GCI+ EMI G LFPGT+ +Q I + +GTP+ S L Sbjct: 177 PDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNES----L 232 Query: 251 QPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRIS 310 P+V + P P L + + L +L ++P+ R+S Sbjct: 233 WPSVTKLPKYNPNIQQRP-----PRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLS 287 Query: 311 VDEALKHEYINVWYD 325 +AL H + +Y Sbjct: 288 AKQALHHPWFAEYYH 302 >3NCG-A nrPDB Length = 486 Score = 292 bits (748), Expect = 1e-79, Method: Composition-based stats. Identities = 86/335 (25%), Positives = 140/335 (41%), Gaps = 46/335 (13%) Query: 19 TIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLV 78 T RY + +G G+ G V D ITQQ A+K +++ RE +L+K + Sbjct: 19 TFAERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKL 78 Query: 79 NHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGIK 138 +H NI+ L + ++Y EL D + + + ++ Q+ GI Sbjct: 79 DHPNIMKLFEILEDSSSFYIVGELYTGGELFDEIIK---RKRFSEHDAARIIKQVFSGIT 135 Query: 139 HLHSAGIIHRDLKPSNIVVKA---DCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVI 195 ++H I+HRDLKP NI++++ DC +KI+DFGL+ M + T YY APEV+ Sbjct: 136 YMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVL 195 Query: 196 LGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVR 255 G Y E D+WS G I+ ++ G F G + D ++ Sbjct: 196 RGT-YDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRV-------------------- 234 Query: 256 NYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEAL 315 Y+FD R + DA++L+ KML P RI+ + L Sbjct: 235 -------ETGKYAFD------------LPQWRTISDDAKDLIRKMLTFHPSLRITATQCL 275 Query: 316 KHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQ 350 +H +I + + P + R+ E+ Sbjct: 276 EHPWIQKYSSETPTISDLPSLESAMTNIRQFQAEK 310 >3RP9-A nrPDB Length = 458 Score = 291 bits (746), Expect = 3e-79, Method: Composition-based stats. Identities = 125/412 (30%), Positives = 203/412 (49%), Gaps = 79/412 (19%) Query: 16 TNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLM 75 +++ I RY IG+G+ G VC AYD + ++ VAIKK+ R F+++ KR RE ++ Sbjct: 47 SDWQIPDRYEIRHLIGTGSYGHVCEAYDKLEKRVVAIKKILRVFEDLIDCKRILREIAIL 106 Query: 76 KLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMD--LDHDRMSYLLYQM 133 +NH +++ +L+ P+ ++E+F ++Y+V+E+ D++ ++ + L + LLY + Sbjct: 107 NRLNHDHVVKVLDIVIPK-DVEKFDELYVVLEIADSDFKKLFRTPVYLTELHIKTLLYNL 165 Query: 134 LCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTF--------------- 178 L G+K++HSAGI+HRDLKP+N +V DC++K+ DFGLART Sbjct: 166 LVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFGLARTVDYPENGNSQLPISPREDDM 225 Query: 179 -------------MMTPYVVTRYYRAPE-VILGMGYTENVDIWSVGCIMGEMIR------ 218 +T +VVTR+YRAPE ++L YTE +D+WS+GCI E++ Sbjct: 226 NLVTFPHTKNLKRQLTGHVVTRWYRAPELILLQENYTEAIDVWSIGCIFAELLNMIKENV 285 Query: 219 -----GGVLFPGTD--------------------HIDQWNKIIEQLGTPSPSFMQRL-QP 252 G LFPG+ + DQ N I LGTPS ++ L + Sbjct: 286 AYHADRGPLFPGSSCFPLSPDQKAGNDFKFHTRGNRDQLNVIFNILGTPSEEDIEALEKE 345 Query: 253 TVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVD 312 + Y+ P+ G FP ++DA +LL +MLV +P +RI+++ Sbjct: 346 DAKRYIRIFPKREGTDLAERFPAS-------------SADAIHLLKRMLVFNPNKRITIN 392 Query: 313 EALKHEYINVWYDAE-EVDAPAPEPYDHSVDEREHTVEQWKELIYEEVMDYE 363 E L H + AE E +A + D Q + +E+ Y Sbjct: 393 ECLAHPFFKEVRIAEVETNATEKVRLPFN-DWMNMDEPQLRYAFVKEIQRYH 443 >5JN2-A nrPDB Length = 525 Score = 291 bits (744), Expect = 5e-79, Method: Composition-based stats. Identities = 88/321 (27%), Positives = 142/321 (44%), Gaps = 48/321 (14%) Query: 19 TIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRP-FQNVTHAKRAYREFKLMKL 77 RY R +G G+ G V D IT Q A+K +S+ + T + RE +L+K Sbjct: 64 IFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQ 123 Query: 78 VNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGI 137 ++H NI+ L F + +VY EL D + + + ++ Q+L GI Sbjct: 124 LDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIIS---RKRFSEVDAARIIRQVLSGI 180 Query: 138 KHLHSAGIIHRDLKPSNIVVKA---DCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEV 194 ++H I+HRDLKP N+++++ D ++I+DFGL+ + M + T YY APEV Sbjct: 181 TYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEV 240 Query: 195 ILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTV 254 + G Y E D+WS G I+ ++ G F G + D K+ + Sbjct: 241 LHGT-YDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEK----------------- 282 Query: 255 RNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEA 314 Y+F+ ++ + A++L+ KML P RIS +A Sbjct: 283 ----------GKYTFE------------LPQWKKVSESAKDLIRKMLTYVPSMRISARDA 320 Query: 315 LKHEYINVWYDAEEVDAPAPE 335 L HE+I Y E++ P Sbjct: 321 LDHEWIQT-YTKEQISVDVPS 340 >1G3N-A nrPDB Length = 326 Score = 289 bits (741), Expect = 1e-78, Method: Composition-based stats. Identities = 95/316 (30%), Positives = 142/316 (44%), Gaps = 25/316 (7%) Query: 21 HSRYINLRPIGSGAQGIVCAAYD-TITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVN 79 +Y + IG GA G V A D + VA+K++ RE +++ + Sbjct: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLE 69 Query: 80 ---HKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQM----DLDHDRMSYLLYQ 132 H N++ L + T R E + LV E +D +L + + + + +++Q Sbjct: 70 TFEHPNVVRLFDVCTVSRTDRE-TKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQ 128 Query: 133 MLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAP 192 +L G+ LHS ++HRDLKP NI+V + +K+ DFGLAR +T VVT +YRAP Sbjct: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAP 188 Query: 193 EVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQP 252 EV+L Y VD+WSVGCI EM R LF G+ +DQ KI++ +G P R Sbjct: 189 EVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA 248 Query: 253 TVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVD 312 R ++ F ++LL K L +P +RIS Sbjct: 249 LPRQAFHSKSAQPIEKFVT----------------DIDELGKDLLLKCLTFNPAKRISAY 292 Query: 313 EALKHEYINVWYDAEE 328 AL H Y +E Sbjct: 293 SALSHPYFQDLERCKE 308 >3DFA-A nrPDB Length = 286 Score = 289 bits (740), Expect = 1e-78, Method: Composition-based stats. Identities = 83/309 (26%), Positives = 133/309 (43%), Gaps = 46/309 (14%) Query: 19 TIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLV 78 T RY + +G G+ G V D ITQQ A+K +++ RE +L+K + Sbjct: 19 TFAERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKL 78 Query: 79 NHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGIK 138 +H NI+ L + ++Y EL D + + + ++ Q+ GI Sbjct: 79 DHPNIMKLFEILEDSSSFYIVGELYTGGELFDEIIK---RKRFSEHDAARIIKQVFSGIT 135 Query: 139 HLHSAGIIHRDLKPSNIVVKA---DCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVI 195 ++H I+HRDLKP NI++++ DC +KI+DFGL+ M + T YY APEV+ Sbjct: 136 YMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVL 195 Query: 196 LGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVR 255 G Y E D+WS G I+ ++ G F G + D ++ Sbjct: 196 RGT-YDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRV-------------------- 234 Query: 256 NYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEAL 315 Y+FD R + DA++L+ KML P RI+ + L Sbjct: 235 -------ETGKYAFD------------LPQWRTISDDAKDLIRKMLTFHPSLRITATQCL 275 Query: 316 KHEYINVWY 324 +H +I + Sbjct: 276 EHPWIQKYS 284 >4BBM-A nrPDB Length = 331 Score = 288 bits (738), Expect = 2e-78, Method: Composition-based stats. Identities = 101/319 (31%), Positives = 155/319 (48%), Gaps = 25/319 (7%) Query: 11 VEVGDTNFTIHS--RYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRA 68 V++G N S +Y NL +G G+ G+V + T + VAIKK + K A Sbjct: 12 VDLGTENLYFQSMEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIA 71 Query: 69 YREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQM---DLDHDR 125 RE KL+K + H+N++ LL ++ YLV E +D + +++ LD+ Sbjct: 72 MREIKLLKQLRHENLVNLLEVCKKKKRW------YLVFEFVDHTILDDLELFPNGLDYQV 125 Query: 126 MSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTA-GTTFMMTPYV 184 + L+Q++ GI HS IIHRD+KP NI+V +K+ DFG ART + V Sbjct: 126 VQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYDDEV 185 Query: 185 VTRYYRAPEVILGM-GYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPS 243 TR+YRAPE+++G Y + VD+W++GC++ EM G LFPG IDQ I+ LG Sbjct: 186 ATRWYRAPELLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLG--- 242 Query: 244 PSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVI 303 L P + P + G P+ + + + +L K L I Sbjct: 243 -----NLIPRHQELFNKNPVFAGVR----LPEIKEREPLERRYPKLSEVVIDLAKKCLHI 293 Query: 304 DPEQRISVDEALKHEYINV 322 DP++R E L H++ + Sbjct: 294 DPDKRPFCAELLHHDFFQM 312 >5EFQ-A nrPDB Length = 347 Score = 288 bits (737), Expect = 3e-78, Method: Composition-based stats. Identities = 87/324 (26%), Positives = 153/324 (47%), Gaps = 26/324 (8%) Query: 22 SRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHK 81 ++ + IG G G V A D T + VA+KK+ + A RE K+++ + H+ Sbjct: 11 DKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQ 70 Query: 82 NIIGLLNAFTPQRNLEEFQD----VYLVMELMDANLCQVIQMDL---DHDRMSYLLYQML 134 +II + T + + +F+ YLV E MD +L +++ L + + + + Q++ Sbjct: 71 SIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLM 130 Query: 135 CGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLART--AGTTFMMTPYVVTRYYRAP 192 G+ + H +HRD+K SNI++ +K+ DFGLAR + + T V+T +YR P Sbjct: 131 EGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPP 190 Query: 193 EVILGM-GYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQ 251 E++LG YT +D+WS GCI+GE+ +F + Q I G+P P+ + Sbjct: 191 ELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVI 250 Query: 252 PTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISV 311 F+ + P + + + A +L ML +DP +R + Sbjct: 251 KL-------------PYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTA 297 Query: 312 DEALKHEYINVWYDAEEVDAPAPE 335 ++AL+ E++ D E P P+ Sbjct: 298 EQALQCEFL---RDVEPSKMPPPD 318 >4AGU-A nrPDB Length = 311 Score = 286 bits (731), Expect = 1e-77, Method: Composition-based stats. Identities = 93/327 (28%), Positives = 142/327 (43%), Gaps = 27/327 (8%) Query: 20 IHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVN 79 + +Y + IG G+ G+V + T Q VAIKK + K A RE +++K + Sbjct: 1 MMEKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLK 60 Query: 80 HKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVI---QMDLDHDRMSYLLYQMLCG 136 H N++ LL F +R L LV E D + + Q + + + +Q L Sbjct: 61 HPNLVNLLEVFRRKRRLH------LVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQA 114 Query: 137 IKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTA-GTTFMMTPYVVTRYYRAPEVI 195 + H IHRD+KP NI++ +K+ DFG AR G + V TR+YR+PE++ Sbjct: 115 VNFCHKHNCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYDDEVATRWYRSPELL 174 Query: 196 LG-MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTV 254 +G Y VD+W++GC+ E++ G L+PG +DQ I + LG P Q Sbjct: 175 VGDTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTN- 233 Query: 255 RNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEA 314 Y PD + A LL L +DP +R++ ++ Sbjct: 234 -----------QYFSGVKIPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTERLTCEQL 282 Query: 315 LKHEYINVWYDAE----EVDAPAPEPY 337 L H Y + E E D PA Y Sbjct: 283 LHHPYFENIREIEDLAKEHDKPAENLY 309 >3LIJ-A nrPDB Length = 494 Score = 285 bits (730), Expect = 2e-77, Method: Composition-based stats. Identities = 86/329 (26%), Positives = 144/329 (43%), Gaps = 52/329 (15%) Query: 13 VGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREF 72 + + Y ++ +GSGA G V D +T AIK + + + + + E Sbjct: 28 ITSKKGHLSEMYQRVKKLGSGAYGEVLLCRDKVTHVERAIKIIRKTSVSTSSNSKLLEEV 87 Query: 73 KLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN-LCQVI--QMDLDHDRMSYL 129 ++KL++H NI+ L + F +RN YLVME L I +M + + + Sbjct: 88 AVLKLLDHPNIMKLYDFFEDKRN------YYLVMECYKGGELFDEIIHRMKFNEVDAAVI 141 Query: 130 LYQMLCGIKHLHSAGIIHRDLKPSNIVVKA---DCTLKILDFGLARTAGTTFMMTPYVVT 186 + Q+L G+ +LH I+HRDLKP N+++++ D +KI+DFGL+ M + T Sbjct: 142 IKQVLSGVTYLHKHNIVHRDLKPENLLLESKEKDALIKIVDFGLSAVFENQKKMKERLGT 201 Query: 187 RYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSF 246 YY APEV+ Y E D+WS+G I+ ++ G F G + K+ + Sbjct: 202 AYYIAPEVL-RKKYDEKCDVWSIGVILFILLAGYPPFGGQTDQEILRKVEK--------- 251 Query: 247 MQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPE 306 Y+FD + + A++L+ +ML D + Sbjct: 252 ------------------GKYTFDS------------PEWKNVSEGAKDLIKQMLQFDSQ 281 Query: 307 QRISVDEALKHEYINVWYDAEEVDAPAPE 335 +RIS +AL+H +I +E P Sbjct: 282 RRISAQQALEHPWIKEMCSKKESGIELPS 310 >5KZ7-A nrPDB Length = 346 Score = 284 bits (728), Expect = 3e-77, Method: Composition-based stats. Identities = 79/342 (23%), Positives = 143/342 (41%), Gaps = 54/342 (15%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNI 83 Y L+ IG G V A +T + VA+K + + N + ++ +RE ++MK++NH NI Sbjct: 35 YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNI 94 Query: 84 IGLLNAFTPQRNLEEFQDVYLVMELMDAN---LCQVIQMDLDHDRMSYLLYQMLCGIKHL 140 + L ++ L YLVME V + Q++ +++ Sbjct: 95 VKLFEVIETEKTL------YLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYC 148 Query: 141 HSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGY 200 H I+HRDLK N+++ AD +KI DFG + + + + Y APE+ G Y Sbjct: 149 HQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKY 208 Query: 201 T-ENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVE 259 VD+WS+G I+ ++ G + F G + + +++ Sbjct: 209 DGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRG--------------------- 247 Query: 260 NRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEY 319 + ++D NLL K L+++P +R ++++ +K + Sbjct: 248 ----------------------KYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRW 285 Query: 320 INVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYEEVMD 361 +NV ++ +E+ P EP D R + EE+ D Sbjct: 286 MNVGHEDDEL-KPYVEPLPDYKDPRRTELMVSMGYTREEIQD 326 >2VZ6-A nrPDB Length = 313 Score = 284 bits (726), Expect = 5e-77, Method: Composition-based stats. Identities = 76/320 (23%), Positives = 135/320 (42%), Gaps = 46/320 (14%) Query: 11 VEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYR 70 V++G N S Y +G GA +V + Q A K ++ + ++ R Sbjct: 11 VDLGTENLYFQSMYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLER 70 Query: 71 EFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLL 130 E ++ +L+ H NI+ L ++ + + + D+ EL + + + S+ + Sbjct: 71 EARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYY---SEADASHCI 127 Query: 131 YQMLCGIKHLHSAGIIHRDLKPSNIVVKADCT---LKILDFGLA-RTAGTTFMMTPYVVT 186 Q+L + H H G++HRDLKP N+++ + +K+ DFGLA G + T Sbjct: 128 QQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGT 187 Query: 187 RYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSF 246 Y +PEV+ Y + VD+W+ G I+ ++ G F D + +I Sbjct: 188 PGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQI----------- 236 Query: 247 MQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPE 306 + Y F D + P +A++L++KML I+P Sbjct: 237 ----------------KAGAYDFPSPEWDTVTP------------EAKDLINKMLTINPS 268 Query: 307 QRISVDEALKHEYINVWYDA 326 +RI+ EALKH +I+ Sbjct: 269 KRITAAEALKHPWISHRSTV 288 >5ES1-A nrPDB Length = 328 Score = 284 bits (726), Expect = 5e-77, Method: Composition-based stats. Identities = 80/340 (23%), Positives = 144/340 (42%), Gaps = 54/340 (15%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNI 83 Y LR IG G V A +T + VAIK + + N + ++ +RE ++MK +NH NI Sbjct: 17 YRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNI 76 Query: 84 IGLLNAFTPQRNLEEFQDVYLVMELMDAN-LCQVI--QMDLDHDRMSYLLYQMLCGIKHL 140 + L ++ L YLVME A + + + Q++ + + Sbjct: 77 VKLFEVIETEKTL------YLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYC 130 Query: 141 HSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGY 200 H I+HRDLK N+++ A+ +KI DFG + + + + Y APE+ G Y Sbjct: 131 HQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKY 190 Query: 201 T-ENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVE 259 VDIWS+G I+ ++ G + F G + + +++ Sbjct: 191 DGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRG--------------------- 229 Query: 260 NRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEY 319 + ++D ++L + LV++P +R ++++ +K ++ Sbjct: 230 ----------------------KYRVPFYMSTDCESILRRFLVLNPAKRCTLEQIMKDKW 267 Query: 320 INVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYEEV 359 IN+ Y+ EE+ P EP + D + V EE+ Sbjct: 268 INIGYEGEEL-KPYTEPEEDFGDTKRIEVMVGMGYTREEI 306 >3N9X-A nrPDB Length = 432 Score = 283 bits (725), Expect = 6e-77, Method: Composition-based stats. Identities = 117/417 (28%), Positives = 197/417 (47%), Gaps = 72/417 (17%) Query: 2 TTAQHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQN 61 + ++ ++ G N + YI IG G+ G V AYD T++NVAIKK++R F++ Sbjct: 9 SGRENLYFQ---GIKNVHVPDNYIIKHLIGRGSYGYVYLAYDKNTEKNVAIKKVNRMFED 65 Query: 62 VTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMD- 120 + KR RE ++ + II L + P L+ F ++Y+V+E+ D++L ++ + Sbjct: 66 LIDCKRILREITILNRLKSDYIIRLYDLIIPDDLLK-FDELYIVLEIADSDLKKLFKTPI 124 Query: 121 -LDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTT-- 177 L + + +LY +L G +H +GIIHRDLKP+N ++ DC++K+ DFGLART + Sbjct: 125 FLTEEHIKTILYNLLLGENFIHESGIIHRDLKPANCLLNQDCSVKVCDFGLARTINSEKD 184 Query: 178 ---------------------FMMTPYVVTRYYRAPE-VILGMGYTENVDIWSVGCIMGE 215 +T +VVTR+YRAPE ++L YT+++DIWS GCI E Sbjct: 185 TNIVNDLEENEEPGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAE 244 Query: 216 MI-----------RGGVLFPGT-----------------DHIDQWNKIIEQLGTPSPSFM 247 ++ LFPG+ + DQ N I +GTP+ + Sbjct: 245 LLNMLQSHINDPTNRFPLFPGSSCFPLSPDRNSKKVHEKSNRDQLNIIFNIIGTPTEDDL 304 Query: 248 QRL-QPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPE 306 + + +P V Y++ P + + +P + D NLL ML +P Sbjct: 305 KNINKPEVIKYIKLFPHRKPINLKQKYPS-------------ISDDGINLLESMLKFNPN 351 Query: 307 QRISVDEALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYEEVMDYE 363 +RI++D+AL H Y+ + + + D + Q + + +EV + Sbjct: 352 KRITIDQALDHPYLKDVRKKKLENFSTKKIILPFDDWMVLSETQLRYIFLKEVQSFH 408 >3PG1-A nrPDB Length = 362 Score = 283 bits (724), Expect = 1e-76, Method: Composition-based stats. Identities = 114/358 (31%), Positives = 171/358 (47%), Gaps = 32/358 (8%) Query: 20 IHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTH---------AKRAYR 70 + S Y R I SG+ G VCA D+ VAIK++ + KR R Sbjct: 20 MQSPYTVQRFISSGSYGAVCAGVDSE-GIPVAIKRVFNTVSDGRTVNILSDSFLCKRVLR 78 Query: 71 EFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMD---LDHDRMS 127 E +L+ +H NI+GL + F +YLV ELM +L QVI + + Sbjct: 79 EIRLLNHFHHPNILGLRDIFVHFEE-PAMHKLYLVTELMRTDLAQVIHDQRIVISPQHIQ 137 Query: 128 YLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTR 187 Y +Y +L G+ LH AG++HRDL P NI++ + + I DF LAR T YV R Sbjct: 138 YFMYHILLGLHVLHEAGVVHRDLHPGNILLADNNDITICDFNLAREDTADANKTHYVTHR 197 Query: 188 YYRAPE-VILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSF 246 +YRAPE V+ G+T+ VD+WS GC+M EM LF G+ +Q NKI+E +GTP Sbjct: 198 WYRAPELVMQFKGFTKLVDMWSAGCVMAEMFNRKALFRGSTFYNQLNKIVEVVGTPKIED 257 Query: 247 MQRL-QPTVRNYVEN-RPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVID 304 + P+ R+Y+ N ++ + P A +L++KML + Sbjct: 258 VVMFSSPSARDYLRNSLSNVPARAWTAVVPTA-------------DPVALDLIAKMLEFN 304 Query: 305 PEQRISVDEALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYEEVMDY 362 P++RIS ++AL+H Y +D ++ E + DE V ++ EV + Sbjct: 305 PQRRISTEQALRHPYFESLFDPLDLTEGLSERF--HFDESVTDVYDMHKIFTAEVERF 360 >3MA6-A nrPDB Length = 298 Score = 283 bits (723), Expect = 1e-76, Method: Composition-based stats. Identities = 85/309 (27%), Positives = 138/309 (44%), Gaps = 47/309 (15%) Query: 19 TIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRP-FQNVTHAKRAYREFKLMKL 77 RY R +G G+ G V D IT Q A+K +S+ + T + RE +L+K Sbjct: 29 IFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQ 88 Query: 78 VNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGI 137 ++H NI+ L F + +VY EL D + + + ++ Q+L GI Sbjct: 89 LDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIIS---RKRFSEVDAARIIRQVLSGI 145 Query: 138 KHLHSAGIIHRDLKPSNIVVKA---DCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEV 194 ++H I+HRDLKP N+++++ D ++I+DFGL+ + M + T YY APEV Sbjct: 146 TYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEV 205 Query: 195 ILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTV 254 + G Y E D+WS G I+ ++ G F G + D K+ + Sbjct: 206 LHGT-YDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEK----------------- 247 Query: 255 RNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEA 314 Y+F+ ++ + A++L+ KML P RIS +A Sbjct: 248 ----------GKYTFE------------LPQWKKVSESAKDLIRKMLTYVPSMRISARDA 285 Query: 315 LKHEYINVW 323 L HE+I + Sbjct: 286 LDHEWIQTY 294 >4NST-A nrPDB Length = 351 Score = 283 bits (723), Expect = 1e-76, Method: Composition-based stats. Identities = 88/342 (25%), Positives = 158/342 (46%), Gaps = 27/342 (7%) Query: 22 SRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHK 81 ++ + IG G G V A D T + VA+KK+ + A RE K+++ + H+ Sbjct: 13 DKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHR 72 Query: 82 NIIGLLNAFTPQRNLEEFQD----VYLVMELMDANLCQVIQMDL---DHDRMSYLLYQML 134 +++ + T +++ +F+ YLV E MD +L +++ L D + + Q++ Sbjct: 73 SVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLM 132 Query: 135 CGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTF--MMTPYVVTRYYRAP 192 G+++ H +HRD+K SNI++ +K+ DFGLAR + T V+T +YR P Sbjct: 133 EGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPP 192 Query: 193 EVILGM-GYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQ 251 E++LG YT +D+WS GCI+GE+ +F + Q I G+P P+ + Sbjct: 193 ELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVI 252 Query: 252 PTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISV 311 F+ + P + + S A +LL ML +DP +R + Sbjct: 253 KL-------------PYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTA 299 Query: 312 DEALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKE 353 ++ L+ +++ D E P+ H D E ++ + Sbjct: 300 EQTLQSDFLK---DVELSKMAPPDL-PHWQDCHELWSKKRRR 337 >3HZT-A nrPDB Length = 467 Score = 281 bits (719), Expect = 3e-76, Method: Composition-based stats. Identities = 82/316 (25%), Positives = 136/316 (43%), Gaps = 47/316 (14%) Query: 20 IHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAY-REFKLMKLV 78 + RY ++ +GSGA G V D +T AIK + + T A E ++K + Sbjct: 2 LSDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQL 61 Query: 79 NHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGIK 138 +H NI+ L F +RN +VY EL D +++ + ++ Q+L G Sbjct: 62 DHPNIMKLYEFFEDKRNYYLVMEVYRGGELFDEI---ILRQKFSEVDAAVIMKQVLSGTT 118 Query: 139 HLHSAGIIHRDLKPSNIVVKA---DCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVI 195 +LH I+HRDLKP N+++++ D +KI+DFGL+ M + T YY APEV+ Sbjct: 119 YLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAPEVL 178 Query: 196 LGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVR 255 Y E D+WS G I+ ++ G F G + ++ + + P Sbjct: 179 R-KKYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEKGKFSFDPP---------- 227 Query: 256 NYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEAL 315 + + + +A+ L+ ML +P +RIS +EAL Sbjct: 228 -----------------------------DWTQVSDEAKQLVKLMLTYEPSKRISAEEAL 258 Query: 316 KHEYINVWYDAEEVDA 331 H +I + + D Sbjct: 259 NHPWIVKFCSQKHTDV 274 >2W96-B nrPDB Length = 306 Score = 279 bits (714), Expect = 1e-75, Method: Composition-based stats. Identities = 104/310 (33%), Positives = 143/310 (46%), Gaps = 32/310 (10%) Query: 22 SRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVN-- 79 SRY + IG GA G V A D + VA+K + P RE L++ + Sbjct: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGLPISTVREVALLRRLEAF 63 Query: 80 -HKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQM----DLDHDRMSYLLYQML 134 H N++ L++ R E + V LV E +D +L + L + + L+ Q L Sbjct: 64 EHPNVVRLMDVCATSRTDREIK-VTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFL 122 Query: 135 CGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEV 194 G+ LH+ I+HRDLKP NI+V + T+K+ DFGLAR + P VVT +YRAPEV Sbjct: 123 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALDPVVVTLWYRAPEV 182 Query: 195 ILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTV 254 +L Y VD+WSVGCI EM R LF G DQ KI + +G P R Sbjct: 183 LLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR----- 237 Query: 255 RNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASD----ARNLLSKMLVIDPEQRIS 310 D P G FP + + + LL +ML +P +RIS Sbjct: 238 ---------------DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRIS 282 Query: 311 VDEALKHEYI 320 AL+H Y+ Sbjct: 283 AFRALQHSYL 292 >2QNJ-A nrPDB Length = 328 Score = 279 bits (714), Expect = 1e-75, Method: Composition-based stats. Identities = 78/342 (22%), Positives = 143/342 (41%), Gaps = 54/342 (15%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNI 83 Y L+ IG G V A +T + VAIK + + N T ++ +RE ++MK++NH NI Sbjct: 14 YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNI 73 Query: 84 IGLLNAFTPQRNLEEFQDVYLVMELMDAN---LCQVIQMDLDHDRMSYLLYQMLCGIKHL 140 + L ++ L YL+ME V + Q++ +++ Sbjct: 74 VKLFEVIETEKTL------YLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYC 127 Query: 141 HSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGY 200 H I+HRDLK N+++ AD +KI DFG + + + + Y APE+ G Y Sbjct: 128 HQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKY 187 Query: 201 T-ENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVE 259 VD+WS+G I+ ++ G + F G + + +++ Sbjct: 188 DGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRG--------------------- 226 Query: 260 NRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEY 319 + ++D NLL + LV++P +R ++++ +K + Sbjct: 227 ----------------------KYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRW 264 Query: 320 INVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYEEVMD 361 IN ++ +E+ P EP D++ + EE+ + Sbjct: 265 INAGHEEDEL-KPFVEPELDISDQKRIDIMVGMGYSQEEIQE 305 >1UA2-A nrPDB Length = 346 Score = 278 bits (712), Expect = 2e-75, Method: Composition-based stats. Identities = 99/315 (31%), Positives = 159/315 (50%), Gaps = 29/315 (9%) Query: 22 SRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTH---AKRAYREFKLMKLV 78 RY L +G G V A D T Q VAIKK+ ++ + A RE KL++ + Sbjct: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 Query: 79 NHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMD---LDHDRMSYLLYQMLC 135 +H NIIGLL+AF + N+ LV + M+ +L +I+ + L + + L Sbjct: 70 SHPNIIGLLDAFGHKSNIS------LVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQ 123 Query: 136 GIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGT-TFMMTPYVVTRYYRAPEV 194 G+++LH I+HRDLKP+N+++ + LK+ DFGLA++ G+ T VVTR+YRAPE+ Sbjct: 124 GLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPEL 183 Query: 195 ILGMG-YTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPT 253 + G Y VD+W+VGCI+ E++ PG +DQ +I E LGTP+ + + Sbjct: 184 LFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDM-CS 242 Query: 254 VRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDE 313 + +YV + + G +F D +L+ + + +P RI+ + Sbjct: 243 LPDYVTFK-SFPGIPLHHIFSAA-------------GDDLLDLIQGLFLFNPCARITATQ 288 Query: 314 ALKHEYINVWYDAEE 328 ALK +Y + Sbjct: 289 ALKMKYFSNRPGPTP 303 >3DXN-A nrPDB Length = 287 Score = 278 bits (712), Expect = 2e-75, Method: Composition-based stats. Identities = 83/314 (26%), Positives = 134/314 (42%), Gaps = 50/314 (15%) Query: 14 GDTNFTIH---SRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAY- 69 G N RY ++ +GSGA G V D +T AIK + + T A Sbjct: 10 GRENLYFQGLSDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALL 69 Query: 70 REFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYL 129 E ++K ++H NI+ L F +RN +VY EL D +++ + + Sbjct: 70 DEVAVLKQLDHPNIMKLYEFFEDKRNYYLVMEVYRGGELFDEI---ILRQKFSEVDAAVI 126 Query: 130 LYQMLCGIKHLHSAGIIHRDLKPSNIVVKA---DCTLKILDFGLARTAGTTFMMTPYVVT 186 + Q+L G +LH I+HRDLKP N+++++ D +KI+DFGL+ M + T Sbjct: 127 MKQVLSGTTYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGT 186 Query: 187 RYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSF 246 YY APEV+ Y E D+WS G I+ ++ G F G + ++ + + P Sbjct: 187 AYYIAPEVLR-KKYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEKGKFSFDPP- 244 Query: 247 MQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPE 306 + + + +A+ L+ ML +P Sbjct: 245 --------------------------------------DWTQVSDEAKQLVKLMLTYEPS 266 Query: 307 QRISVDEALKHEYI 320 +RIS +EAL H +I Sbjct: 267 KRISAEEALNHPWI 280 >4MVF-A nrPDB Length = 506 Score = 278 bits (710), Expect = 4e-75, Method: Composition-based stats. Identities = 87/310 (28%), Positives = 134/310 (43%), Gaps = 54/310 (17%) Query: 20 IHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVN 79 + +YI +G G G V D +T Q AIK+ + + R ++E ++MK ++ Sbjct: 55 LEDKYIIDEKLGQGTYGCVYKGIDKVTNQLYAIKEEKKDRLK--NINRFFQEIEIMKKLD 112 Query: 80 HKNIIGLLNAFTPQRNLEEFQDVYLVMELMDA-NLCQVI--QMDLDHDRMSYLLYQMLCG 136 H NI+ L + E +YL+MEL L I + ++ Q+ Sbjct: 113 HPNIVKLYETY------ENDNYIYLIMELCSGRELFDSIIENGSFTEKNAATIMKQIFSA 166 Query: 137 IKHLHSAGIIHRDLKPSNIVV---KADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPE 193 I +LHS I+HRDLKP N + D LKI+DFGL++ GT T T YY AP+ Sbjct: 167 IFYLHSLNIVHRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFTTTKAGTPYYVAPQ 226 Query: 194 VILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPT 253 V+ G Y + DIWS G IM ++ G F G + K+ Sbjct: 227 VLDG-KYDKKCDIWSSGVIMYTLLCGYPPFYGDTDNEVLKKV------------------ 267 Query: 254 VRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDE 313 + + Y D +SDA+NL++K+L +P +R +++E Sbjct: 268 ------KKGEFCFYEND---------------WGSISSDAKNLITKLLTYNPNERCTIEE 306 Query: 314 ALKHEYINVW 323 AL H +I Sbjct: 307 ALNHPWITQM 316 >4E7W-A nrPDB Length = 394 Score = 276 bits (705), Expect = 1e-74, Method: Composition-based stats. Identities = 103/334 (30%), Positives = 174/334 (52%), Gaps = 38/334 (11%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKL--SRPFQNVTHAKRAYREFKLMKLVNHK 81 Y N + IG+G+ G+V A + + VAIKK+ + F+N RE ++M++V H Sbjct: 42 YTNCKVIGNGSFGVVFQAKLVESDE-VAIKKVLQDKRFKN--------RELQIMRIVKHP 92 Query: 82 NIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQ------VIQMDLDHDRMSYLLYQMLC 135 N++ L F + ++ + LV+E + + + ++ + + +YQ+L Sbjct: 93 NVVDLKAFFYSNGDKKDEVFLNLVLEYVPETVYRASRHYAKLKQTMPMLLIKLYMYQLLR 152 Query: 136 GIKHLHSAGIIHRDLKPSNIVVKA-DCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEV 194 + ++HS GI HRD+KP N+++ LK++DFG A+ Y+ +RYYRAPE+ Sbjct: 153 SLAYIHSIGICHRDIKPQNLLLDPPSGVLKLIDFGSAKILIAGEPNVSYICSRYYRAPEL 212 Query: 195 ILG-MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPT 253 I G YT N+DIWS GC+M E+++G LFPG IDQ +II+ LGTPS ++ + P Sbjct: 213 IFGATNYTTNIDIWSTGCVMAELMQGQPLFPGESGIDQLVEIIKVLGTPSREQIKTMNP- 271 Query: 254 VRNYVENR-PRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVD 312 NY+E++ P+ + F ++F R DA +L+S++L P R++ Sbjct: 272 --NYMEHKFPQIRPHPFSKVF------------RPRTPPDAIDLISRLLEYTPSARLTAI 317 Query: 313 EALKHEYINVWYDAE---EVDAPAPEPYDHSVDE 343 EAL H + + E P ++ + +E Sbjct: 318 EALCHPFFDELRTGEARMPNGRELPPLFNWTKEE 351 >3MIA-A nrPDB Length = 351 Score = 276 bits (705), Expect = 1e-74, Method: Composition-based stats. Identities = 90/320 (28%), Positives = 143/320 (44%), Gaps = 24/320 (7%) Query: 22 SRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHK 81 S+Y L IG G G V A T Q VA+KK+ + A RE K+++L+ H+ Sbjct: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHE 76 Query: 82 NIIGLLNAFTPQRNLEEFQD--VYLVMELMD---ANLCQVIQMDLDHDRMSYLLYQMLCG 136 N++ L+ + + +YLV + + A L + + + ++ +L G Sbjct: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNG 136 Query: 137 IKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTA-----GTTFMMTPYVVTRYYRA 191 + ++H I+HRD+K +N+++ D LK+ DFGLAR T VVT +YR Sbjct: 137 LYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRP 196 Query: 192 PEVILG-MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRL 250 PE++LG Y +D+W GCIM EM + G Q I + G+ +P + Sbjct: 197 PELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNV 256 Query: 251 QPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRIS 310 Y Y L + + + A +L+ K+LV+DP QRI Sbjct: 257 D-----------NYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRID 305 Query: 311 VDEALKHEYINVWYDAEEVD 330 D+AL H++ W D D Sbjct: 306 SDDALNHDFF--WSDPMPSD 323 >3NIE-A nrPDB Length = 429 Score = 275 bits (704), Expect = 2e-74, Method: Composition-based stats. Identities = 112/421 (26%), Positives = 191/421 (45%), Gaps = 73/421 (17%) Query: 2 TTAQHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQN 61 + ++ ++ + N + Y IG G+ G V AYD +NVAIKK++R F++ Sbjct: 9 SGRENLYFQGAI-IKNVKVPDNYEIKHLIGRGSYGYVYLAYDKNANKNVAIKKVNRMFED 67 Query: 62 VTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMD- 120 + KR RE ++ + II L + P+ L+ F ++Y+V+E+ D++L ++ + Sbjct: 68 LIDCKRILREITILNRLKSDYIIRLHDLIIPEDLLK-FDELYIVLEIADSDLKKLFKTPI 126 Query: 121 -LDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTT-- 177 L + +LY +L G K +H +GIIHRDLKP+N ++ DC++KI DFGLART + Sbjct: 127 FLTEQHVKTILYNLLLGEKFIHESGIIHRDLKPANCLLNQDCSVKICDFGLARTINSDKD 186 Query: 178 ------------------------FMMTPYVVTRYYRAPE-VILGMGYTENVDIWSVGCI 212 +T +VVTR+YRAPE ++L YT ++DIWS GCI Sbjct: 187 IHIVNDLEEKEENEEPGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDIWSTGCI 246 Query: 213 MGEMI-----------RGGVLFPGT-----------------DHIDQWNKIIEQLGTPSP 244 E++ LFPG+ + DQ N I +GTP Sbjct: 247 FAELLNMMKSHINNPTNRFPLFPGSSCFPLSPDHNSKKVHEKSNRDQLNIIFNVIGTPPE 306 Query: 245 SFMQRL-QPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVI 303 ++ + + V Y++ P G + + + + +LL ML Sbjct: 307 EDLKCITKQEVIKYIKLFPTRDGIDLSKKYSS-------------ISKEGIDLLESMLRF 353 Query: 304 DPEQRISVDEALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYEEVMDYE 363 + ++RI++D+AL H Y+ + + D + Q + + +E+ + Sbjct: 354 NAQKRITIDKALSHPYLKDVRKENLENFSTEKIILPFDDWMVLSETQLRYIFLKEIQSFH 413 Query: 364 A 364 A Sbjct: 414 A 414 >5AIR-A nrPDB Length = 430 Score = 274 bits (701), Expect = 4e-74, Method: Composition-based stats. Identities = 89/314 (28%), Positives = 157/314 (50%), Gaps = 32/314 (10%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKL--SRPFQNVTHAKRAYREFKLMKLVNHK 81 Y + + IG+G+ G+V A + + VAIKK+ + F+N RE ++M+ ++H Sbjct: 66 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN--------RELQIMRKLDHC 117 Query: 82 NIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQ------MDLDHDRMSYLLYQMLC 135 NI+ L F ++ + LV++ + + +V + L + +YQ+ Sbjct: 118 NIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFR 177 Query: 136 GIKHLHSAGIIHRDLKPSNIVVKAD-CTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEV 194 + ++HS GI HRD+KP N+++ D LK+ DFG A+ Y+ +RYYRAPE+ Sbjct: 178 SLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPEL 237 Query: 195 ILG-MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPT 253 I G YT ++D+WS GC++ E++ G +FPG +DQ +II+ LGTP+ ++ + P Sbjct: 238 IFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPN 297 Query: 254 VRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDE 313 + P+ + + ++F R +A L S++L P R++ E Sbjct: 298 YTEF--KFPQIKAHPWTKVF------------RPRTPPEAIALCSRLLEYTPTARLTPLE 343 Query: 314 ALKHEYINVWYDAE 327 A H + + D Sbjct: 344 ACAHSFFDELRDPN 357 >4RGJ-A nrPDB Length = 520 Score = 273 bits (699), Expect = 7e-74, Method: Composition-based stats. Identities = 86/328 (26%), Positives = 148/328 (45%), Gaps = 48/328 (14%) Query: 13 VGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPF-QNVTHAKRAYRE 71 + ++N + +Y ++ +G G+ G V + D T AIK +S+ + T + RE Sbjct: 51 IQNSNVVFNEQYKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKESLLRE 110 Query: 72 FKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLY 131 +L+K+++H NI+ L F DVY EL D + + + ++ Sbjct: 111 VELLKMLDHINIMKLYEFFEDNNYYYLVSDVYTGGELFDEIIS---RKRFYEIDAARIIK 167 Query: 132 QMLCGIKHLHSAGIIHRDLKPSNIVV----KADCTLKILDFGLARTAGTTFMMTPYVVTR 187 Q+L GI ++H ++HRDLKP NI++ K D +KI+DFGL+ + M + T Sbjct: 168 QILSGITYMHKNNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHFEYSKKMKDKIGTA 227 Query: 188 YYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFM 247 YY AP+V+ G Y E DIWS G I+ ++ G F G++ D K+ Sbjct: 228 YYIAPDVLHGT-YDEKCDIWSCGVILYILLSGCPPFNGSNEYDILKKV------------ 274 Query: 248 QRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQ 307 Y + P++ ++ + A++L+ KML+ Sbjct: 275 -----EAGKYTFDLPQF----------------------KKISDKAKDLIKKMLMYTSAV 307 Query: 308 RISVDEALKHEYINVWYDAEEVDAPAPE 335 RIS +AL+HE+I + + ++ P Sbjct: 308 RISARDALEHEWIKMMTSKDNLNIDIPS 335 >2VN9-A nrPDB Length = 301 Score = 273 bits (698), Expect = 8e-74, Method: Composition-based stats. Identities = 74/306 (24%), Positives = 129/306 (42%), Gaps = 46/306 (15%) Query: 19 TIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLV 78 ++ Y +G GA +V T Q A K ++ + ++ RE ++ +L+ Sbjct: 1 SMTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLL 60 Query: 79 NHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGIK 138 H NI+ L ++ + + D+ EL + + + S+ + Q+L + Sbjct: 61 KHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYY---SEADASHCIQQILESVN 117 Query: 139 HLHSAGIIHRDLKPSNIVVKADCT---LKILDFGLA-RTAGTTFMMTPYVVTRYYRAPEV 194 H H GI+HRDLKP N+++ + +K+ DFGLA G + T Y +PEV Sbjct: 118 HCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEV 177 Query: 195 ILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTV 254 + Y + VD+W+ G I+ ++ G F D + +I Sbjct: 178 LRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQI------------------- 218 Query: 255 RNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEA 314 + Y F D + P +A++L++KML I+P +RI+ EA Sbjct: 219 --------KAGAYDFPSPEWDTVTP------------EAKDLINKMLTINPAKRITASEA 258 Query: 315 LKHEYI 320 LKH +I Sbjct: 259 LKHPWI 264 >5U6Y-A nrPDB Length = 461 Score = 273 bits (697), Expect = 1e-73, Method: Composition-based stats. Identities = 72/308 (23%), Positives = 129/308 (41%), Gaps = 46/308 (14%) Query: 23 RYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKN 82 Y +G GA +V + Q A K ++ + ++ RE ++ +L+ H N Sbjct: 1 MYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPN 60 Query: 83 IIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGIKHLHS 142 I+ L ++ + + + D+ EL + + + S+ + Q+L + H H Sbjct: 61 IVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYY---SEADASHCIQQILEAVLHCHQ 117 Query: 143 AGIIHRDLKPSNIVVKADCT---LKILDFGLA-RTAGTTFMMTPYVVTRYYRAPEVILGM 198 G++HRDLKP N+++ + +K+ DFGLA G + T Y +PEV+ Sbjct: 118 MGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKD 177 Query: 199 GYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYV 258 Y + VD+W+ G I+ ++ G F D + +I Sbjct: 178 PYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQI----------------------- 214 Query: 259 ENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHE 318 + Y F D + P +A++L++KML I+P +RI+ EALKH Sbjct: 215 ----KAGAYDFPSPEWDTVTP------------EAKDLINKMLTINPSKRITAAEALKHP 258 Query: 319 YINVWYDA 326 +I+ Sbjct: 259 WISHRSTV 266 >2BDW-A nrPDB Length = 362 Score = 271 bits (694), Expect = 3e-73, Method: Composition-based stats. Identities = 68/304 (22%), Positives = 125/304 (41%), Gaps = 45/304 (14%) Query: 20 IHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVN 79 Y +G GA +V T A K ++ + ++ RE ++ + + Sbjct: 27 FSDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQ 86 Query: 80 HKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGIKH 139 H NI+ L ++ + D+ EL + + + S+ + Q+L I + Sbjct: 87 HPNIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFY---SEADASHCIQQILESIAY 143 Query: 140 LHSAGIIHRDLKPSNIVVKADCT---LKILDFGLARTAGTTFMMTPYVVTRYYRAPEVIL 196 HS GI+HR+LKP N+++ + +K+ DFGLA + + T Y +PEV+ Sbjct: 144 CHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVLK 203 Query: 197 GMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRN 256 Y++ VDIW+ G I+ ++ G F D + +I Sbjct: 204 KDPYSKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQI--------------------- 242 Query: 257 YVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALK 316 + Y + D + P +A++L+ ML ++P++RI+ D+ALK Sbjct: 243 ------KAGAYDYPSPEWDTVTP------------EAKSLIDSMLTVNPKKRITADQALK 284 Query: 317 HEYI 320 +I Sbjct: 285 VPWI 288 >2V7O-A nrPDB Length = 336 Score = 271 bits (694), Expect = 3e-73, Method: Composition-based stats. Identities = 77/323 (23%), Positives = 135/323 (41%), Gaps = 55/323 (17%) Query: 11 VEVGDTNFTIHSR---------YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQN 61 V++G N S Y +G GA +V Q A K ++ + Sbjct: 11 VDLGTENLYFQSMATCTRFTDDYQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKKLS 70 Query: 62 VTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDL 121 ++ RE ++ +L+ H NI+ L ++ + + D+ EL + + + Sbjct: 71 ARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYY--- 127 Query: 122 DHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCT---LKILDFGLARTA-GTT 177 S+ ++Q+L + H+H I+HRDLKP N+++ + C +K+ DFGLA G Sbjct: 128 SEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQ 187 Query: 178 FMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIE 237 + T Y +PEV+ Y + VDIW+ G I+ ++ G F D + +I Sbjct: 188 QAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQI-- 245 Query: 238 QLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLL 297 + Y F D + P +A+NL+ Sbjct: 246 -------------------------KAGAYDFPSPEWDTVTP------------EAKNLI 268 Query: 298 SKMLVIDPEQRISVDEALKHEYI 320 ++ML I+P +RI+ D+ALKH ++ Sbjct: 269 NQMLTINPAKRITADQALKHPWV 291 >4CFF-A nrPDB Length = 571 Score = 271 bits (693), Expect = 4e-73, Method: Composition-based stats. Identities = 87/345 (25%), Positives = 134/345 (38%), Gaps = 58/345 (16%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSR-PFQNVTHAKRAYREFKLMKLVNHKN 82 Y+ +G G G V +T VA+K L+R +++ + RE + +KL H + Sbjct: 35 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 94 Query: 83 IIGLLNAFTPQRNLEEFQDVYLVMELMDAN-LCQVI--QMDLDHDRMSYLLYQMLCGIKH 139 II L + D ++VME + L I ++ L Q+L + + Sbjct: 95 IIKLYQVISTP------TDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDY 148 Query: 140 LHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMG 199 H ++HRDLKP N+++ A KI DFGL+ + + Y APEVI G Sbjct: 149 CHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRL 208 Query: 200 Y-TENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYV 258 Y VDIWS G I+ ++ G + F +H+ K I P ++ R T Sbjct: 209 YAGPEVDIWSCGVILYALLCGTLPF-DDEHVPTLFKKIRGGVFYIPEYLNRSVAT----- 262 Query: 259 ENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHE 318 LL ML +DP +R ++ + +HE Sbjct: 263 -------------------------------------LLMHMLQVDPLKRATIKDIREHE 285 Query: 319 YINVWYDAEEVDAPAPEPYDHSV--DEREHTVEQWKELIYEEVMD 361 + D P YD +V DE V + E EVM+ Sbjct: 286 WFKQ--DLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMN 328 >4BGQ-A nrPDB Length = 304 Score = 271 bits (692), Expect = 4e-73, Method: Composition-based stats. Identities = 92/307 (29%), Positives = 149/307 (48%), Gaps = 22/307 (7%) Query: 20 IHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVN 79 + +++ L +G GA G+V T + VAIKK +N + RE K+++ + Sbjct: 10 VMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLK 69 Query: 80 HKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQM---DLDHDRMSYLLYQMLCG 136 +NI+ L AF + L YLV E ++ N+ ++++ + +++ +YQ++ Sbjct: 70 QENIVELKEAFRRRGKL------YLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKA 123 Query: 137 IKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTA--GTTFMMTPYVVTRYYRAPEV 194 I H I+HRD+KP N+++ + LK+ DFG AR G V TR+YR+PE+ Sbjct: 124 IHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYDEEVATRWYRSPEL 183 Query: 195 ILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTV 254 +LG Y ++VD+WSVGCI+GE+ G LFPG IDQ I + LG P PS +L Sbjct: 184 LLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLG-PLPSEQMKL---- 238 Query: 255 RNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEA 314 + PR+ G F + +L+ +L +DP R ++ Sbjct: 239 ---FYSNPRFHGLRFPAVNHPQSLERRYLGILNSV---LLDLMKNLLKLDPADRYLTEQC 292 Query: 315 LKHEYIN 321 L H Sbjct: 293 LNHPTFQ 299 >2I6L-A nrPDB Length = 320 Score = 270 bits (690), Expect = 8e-73, Method: Composition-based stats. Identities = 99/334 (29%), Positives = 167/334 (50%), Gaps = 30/334 (8%) Query: 13 VGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREF 72 + F + SRY++L+P+G G G+V +A D + VAIKK+ + K A RE Sbjct: 2 MNIHGFDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKI--VLTDPQSVKHALREI 59 Query: 73 KLMKLVNHKNIIGLLNAFTPQRN--------LEEFQDVYLVMELMDANLCQVIQM-DLDH 123 K+++ ++H NI+ + P + L E VY+V E M+ +L V++ L Sbjct: 60 KIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLE 119 Query: 124 DRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-ADCTLKILDFGLARTAGTTFMMTP 182 + +YQ+L G+K++HSA ++HRDLKP+N+ + D LKI DFGLAR + Sbjct: 120 EHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKG 179 Query: 183 YV----VTRYYRAPEVILG-MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIE 237 ++ VT++YR+P ++L YT+ +D+W+ GCI EM+ G LF G ++Q I+E Sbjct: 180 HLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILE 239 Query: 238 QLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLL 297 + Q L + Y+ N +L P + +A + L Sbjct: 240 SIPVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLP-------------GISREAVDFL 286 Query: 298 SKMLVIDPEQRISVDEALKHEYINVWYDAEEVDA 331 ++L P R++ +EAL H Y++++ + Sbjct: 287 EQILTFSPMDRLTAEEALSHPYMSIYSFPMDEPI 320 >5EZV-A nrPDB Length = 560 Score = 269 bits (689), Expect = 1e-72, Method: Composition-based stats. Identities = 87/345 (25%), Positives = 134/345 (38%), Gaps = 58/345 (16%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSR-PFQNVTHAKRAYREFKLMKLVNHKN 82 Y+ +G G G V +T VA+K L+R +++ + RE + +KL H + Sbjct: 30 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 89 Query: 83 IIGLLNAFTPQRNLEEFQDVYLVMELMDAN-LCQVI--QMDLDHDRMSYLLYQMLCGIKH 139 II L + D ++VME + L I ++ L Q+L + + Sbjct: 90 IIKLYQVISTP------TDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDY 143 Query: 140 LHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMG 199 H ++HRDLKP N+++ A KI DFGL+ + + Y APEVI G Sbjct: 144 CHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRL 203 Query: 200 Y-TENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYV 258 Y VDIWS G I+ ++ G + F +H+ K I P ++ R T Sbjct: 204 YAGPEVDIWSCGVILYALLCGTLPF-DDEHVPTLFKKIRGGVFYIPEYLNRSVAT----- 257 Query: 259 ENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHE 318 LL ML +DP +R ++ + +HE Sbjct: 258 -------------------------------------LLMHMLQVDPLKRATIKDIREHE 280 Query: 319 YINVWYDAEEVDAPAPEPYDHSV--DEREHTVEQWKELIYEEVMD 361 + D P YD +V DE V + E EVM+ Sbjct: 281 WFKQ--DLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMN 323 >5FG8-A nrPDB Length = 285 Score = 268 bits (686), Expect = 2e-72, Method: Composition-based stats. Identities = 71/305 (23%), Positives = 126/305 (41%), Gaps = 46/305 (15%) Query: 20 IHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVN 79 Y +G GA IV T A K ++ ++ RE ++ + ++ Sbjct: 12 FSDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLH 71 Query: 80 HKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGIKH 139 H NI+ L ++ + D+ EL + + + S+ + Q+L + H Sbjct: 72 HPNIVRLHDSIQEENYHYLVFDLVTGGELFEDIVAREFY---SEADASHCIQQILESVNH 128 Query: 140 LHSAGIIHRDLKPSNIVVKADCT---LKILDFGLARTA-GTTFMMTPYVVTRYYRAPEVI 195 H G++HRDLKP N+++ + +K+ DFGLA G + T Y +PEV+ Sbjct: 129 CHQNGVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVL 188 Query: 196 LGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVR 255 Y ++VDIW+ G I+ ++ G F D +++I Sbjct: 189 KKEPYGKSVDIWACGVILYILLVGYPPFWDEDQHRLYSQI-------------------- 228 Query: 256 NYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEAL 315 + Y + D + P +A+NL+++ML ++P +RI+ EAL Sbjct: 229 -------KAGAYDYPSPEWDTVTP------------EAKNLINQMLTVNPNKRITAAEAL 269 Query: 316 KHEYI 320 KH +I Sbjct: 270 KHPWI 274 >4YZB-A nrPDB Length = 491 Score = 268 bits (685), Expect = 3e-72, Method: Composition-based stats. Identities = 87/321 (27%), Positives = 145/321 (45%), Gaps = 48/321 (14%) Query: 20 IHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRP-FQNVTHAKRAYREFKLMKLV 78 RY R +G G+ G V D +T Q A+K +S+ + T + +E +L+K + Sbjct: 28 FSDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTDKELLLKEVELLKKL 87 Query: 79 NHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGIK 138 +H NI+ L F + +VY EL D + + + ++ Q+L GI Sbjct: 88 DHPNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIIS---RKRFSEVDAARIIRQVLSGIT 144 Query: 139 HLHSAGIIHRDLKPSNIVVKA---DCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVI 195 ++H I+HRDLKP N++++ D ++I+DFGL+ +T M + T YY APEV+ Sbjct: 145 YMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAPEVL 204 Query: 196 LGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVR 255 G Y E D+WS G I+ ++ G F G + D K+ + Sbjct: 205 HGT-YDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEK------------------ 245 Query: 256 NYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEAL 315 ++FD ++ + A++L+ KML P RIS +AL Sbjct: 246 ---------GKFTFD------------LPQWKKVSEPAKDLIRKMLAYVPTMRISARDAL 284 Query: 316 KHEYINVWYDA-EEVDAPAPE 335 +HE++ A + +D P+ E Sbjct: 285 EHEWLKTTDAATDSIDVPSLE 305 >3GC0-A nrPDB Length = 329 Score = 268 bits (685), Expect = 3e-72, Method: Composition-based stats. Identities = 98/310 (31%), Positives = 149/310 (48%), Gaps = 28/310 (9%) Query: 22 SRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHK 81 RY + +G G G V A DT+T + VAIK++ + A RE L+K + H+ Sbjct: 34 DRYRRITKLGEGTYGEVYKAIDTVTNETVAIKRIRLEHEEEGVPGTAIREVSLLKELQHR 93 Query: 82 NIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQM--DLDHDRMSYLLYQMLCGIKH 139 NII L + L L+ E + +L + + D+ + LYQ++ G+ Sbjct: 94 NIIELKSVIHHNHRLH------LIFEYAENDLKKYMDKNPDVSMRVIKSFLYQLINGVNF 147 Query: 140 LHSAGIIHRDLKPSNIVV-----KADCTLKILDFGLARTAG-TTFMMTPYVVTRYYRAPE 193 HS +HRDLKP N+++ LKI DFGLAR G T ++T +YR PE Sbjct: 148 CHSRRCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQFTHEIITLWYRPPE 207 Query: 194 VILG-MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQP 252 ++LG Y+ +VDIWS+ CI EM+ LFPG IDQ KI E LG P + + Sbjct: 208 ILLGSRHYSTSVDIWSIACIWAEMLMKTPLFPGDSEIDQLFKIFEVLGLPDDTTWPGVT- 266 Query: 253 TVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVD 312 + ++ ++ P++ G + R+ L + + ML +DP +RIS Sbjct: 267 ALPDWKQSFPKFRGKTLKRVLGALLDDEGLDLLTA------------MLEMDPVKRISAK 314 Query: 313 EALKHEYINV 322 AL+H Y + Sbjct: 315 NALEHPYFSH 324 >3KK8-A nrPDB Length = 284 Score = 268 bits (685), Expect = 3e-72, Method: Composition-based stats. Identities = 68/304 (22%), Positives = 125/304 (41%), Gaps = 45/304 (14%) Query: 20 IHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVN 79 Y +G GA +V T A K ++ + ++ RE ++ + + Sbjct: 4 FSDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQ 63 Query: 80 HKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGIKH 139 H NI+ L ++ + D+ EL + + + S+ + Q+L I + Sbjct: 64 HPNIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFY---SEADASHCIQQILESIAY 120 Query: 140 LHSAGIIHRDLKPSNIVVKADCT---LKILDFGLARTAGTTFMMTPYVVTRYYRAPEVIL 196 HS GI+HR+LKP N+++ + +K+ DFGLA + + T Y +PEV+ Sbjct: 121 CHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVLK 180 Query: 197 GMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRN 256 Y++ VDIW+ G I+ ++ G F D + +I Sbjct: 181 KDPYSKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQI--------------------- 219 Query: 257 YVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALK 316 + Y + D + P +A++L+ ML ++P++RI+ D+ALK Sbjct: 220 ------KAGAYDYPSPEWDTVTP------------EAKSLIDSMLTVNPKKRITADQALK 261 Query: 317 HEYI 320 +I Sbjct: 262 VPWI 265 >4REW-A nrPDB Length = 540 Score = 266 bits (681), Expect = 8e-72, Method: Composition-based stats. Identities = 86/345 (24%), Positives = 133/345 (38%), Gaps = 58/345 (16%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSR-PFQNVTHAKRAYREFKLMKLVNHKN 82 YI +G G G V +T VA+K L+R +++ + RE + +KL H + Sbjct: 8 YILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPH 67 Query: 83 IIGLLNAFTPQRNLEEFQDVYLVMELMDAN-LCQVI--QMDLDHDRMSYLLYQMLCGIKH 139 II L + D+++VME + L I LD L Q+L G+ + Sbjct: 68 IIKLYQVISTPS------DIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDY 121 Query: 140 LHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMG 199 H ++HRDLKP N+++ A KI DFGL+ + + Y APEVI G Sbjct: 122 CHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRL 181 Query: 200 Y-TENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYV 258 Y VDIWS G I+ ++ G + F + KI + + Sbjct: 182 YAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTP--------------- 226 Query: 259 ENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHE 318 + +LL ML +DP +R S+ + +HE Sbjct: 227 ----------------------------QYLNPSVISLLKHMLQVDPMKRASIKDIREHE 258 Query: 319 YINVWYDAEEVDAPAPEPYDHSV--DEREHTVEQWKELIYEEVMD 361 + D + P Y ++ DE V + E EEV+ Sbjct: 259 WFKQ--DLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLS 301 >3BHH-A nrPDB Length = 295 Score = 266 bits (680), Expect = 1e-71, Method: Composition-based stats. Identities = 74/306 (24%), Positives = 129/306 (42%), Gaps = 46/306 (15%) Query: 19 TIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLV 78 ++ Y IG GA +V T A K ++ + ++ RE ++ +L+ Sbjct: 1 SMTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLL 60 Query: 79 NHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGIK 138 H NI+ L ++ + + D+ EL + + + S+ + Q+L + Sbjct: 61 KHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYY---SEADASHCIQQILEAVL 117 Query: 139 HLHSAGIIHRDLKPSNIVVKADCT---LKILDFGLA-RTAGTTFMMTPYVVTRYYRAPEV 194 H H G++HRDLKP N+++ + C +K+ DFGLA G + T Y +PEV Sbjct: 118 HCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEV 177 Query: 195 ILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTV 254 + Y + VDIW+ G I+ ++ G F D + +I Sbjct: 178 LRKEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQI------------------- 218 Query: 255 RNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEA 314 + Y F D + P +A+NL+++ML I+P +RI+ EA Sbjct: 219 --------KAGAYDFPSPEWDTVTP------------EAKNLINQMLTINPAKRITAHEA 258 Query: 315 LKHEYI 320 LKH ++ Sbjct: 259 LKHPWV 264 >5G6V-A nrPDB Length = 324 Score = 265 bits (678), Expect = 2e-71, Method: Composition-based stats. Identities = 92/304 (30%), Positives = 143/304 (47%), Gaps = 25/304 (8%) Query: 22 SRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHK 81 YI L +G G V +T VA+K++ + A RE L+K + H Sbjct: 2 ETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEE-GAPCTAIREVSLLKDLKHA 60 Query: 82 NIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMD---LDHDRMSYLLYQMLCGIK 138 NI+ L + +++L LV E +D +L Q + ++ + L+Q+L G+ Sbjct: 61 NIVTLHDIIHTEKSLT------LVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLA 114 Query: 139 HLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAG-TTFMMTPYVVTRYYRAPEVILG 197 + H ++HRDLKP N+++ LK+ DFGLAR T VVT +YR P+++LG Sbjct: 115 YCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYDNEVVTLWYRPPDILLG 174 Query: 198 M-GYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRN 256 Y+ +D+W VGCI EM G LFPG+ +Q + I LGTP+ + Sbjct: 175 STDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEF 234 Query: 257 YVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALK 316 N P+Y + P R SD +LL+K+L + RIS ++A+K Sbjct: 235 KTYNYPKYRAEALLSHAP-------------RLDSDGADLLTKLLQFEGRNRISAEDAMK 281 Query: 317 HEYI 320 H + Sbjct: 282 HPFF 285 >5Y86-A nrPDB Length = 588 Score = 265 bits (678), Expect = 2e-71, Method: Composition-based stats. Identities = 89/329 (27%), Positives = 155/329 (47%), Gaps = 41/329 (12%) Query: 23 RYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVN--- 79 RY L+ IG G+ G V YD +Q VA+K + ++A E ++++ + Sbjct: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVR---NEKRFHRQAAEEIRILEHLKKQD 264 Query: 80 ---HKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMD----LDHDRMSYLLYQ 132 N+I +L +FT + + V + EL+ +L ++I+ + + Sbjct: 265 KTGSMNVIHMLESFTFRNH------VCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQS 318 Query: 133 MLCGIKHLHSAGIIHRDLKPSNIVVKADCT--LKILDFGLARTAGTTFMMTPYVVTRYYR 190 +L + LH IIH DLKP NI++K K++DFG + + Y+ +R+YR Sbjct: 319 ILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF--EYQKLYTYIQSRFYR 376 Query: 191 APEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRL 250 APE+ILG Y+ +DIWS GCI+ E++ G LFPG D DQ ++E LG P P +++ Sbjct: 377 APEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQ- 435 Query: 251 QPTVRNYVENR--PRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARN------------- 295 + ++ ++ PRY + L + + +R +++ Sbjct: 436 SKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLF 495 Query: 296 --LLSKMLVIDPEQRISVDEALKHEYINV 322 L + L DP R++ +AL+H +I+ Sbjct: 496 IEFLKRCLHWDPSARLTPAQALRHPWISK 524 >3SOA-A nrPDB Length = 444 Score = 264 bits (675), Expect = 4e-71, Method: Composition-based stats. Identities = 70/311 (22%), Positives = 128/311 (41%), Gaps = 46/311 (14%) Query: 20 IHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVN 79 Y +G GA +V + Q A ++ + ++ RE ++ +L+ Sbjct: 9 FTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDHQKLEREARICRLLK 68 Query: 80 HKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGIKH 139 H NI+ L ++ + + + D+ EL + + + S+ + Q+L + H Sbjct: 69 HPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYY---SEADASHCIQQILEAVLH 125 Query: 140 LHSAGIIHRDLKPSNIVVKADCT---LKILDFGLA-RTAGTTFMMTPYVVTRYYRAPEVI 195 H G++HR+LKP N+++ + +K+ DFGLA G + T Y +PEV+ Sbjct: 126 CHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVL 185 Query: 196 LGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVR 255 Y + VD+W+ G I+ ++ G F D + +I Sbjct: 186 RKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQI-------------------- 225 Query: 256 NYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEAL 315 + Y F D + P +A++L++KML I+P +RI+ EAL Sbjct: 226 -------KAGAYDFPSPEWDTVTP------------EAKDLINKMLTINPSKRITAAEAL 266 Query: 316 KHEYINVWYDA 326 KH +I+ Sbjct: 267 KHPWISHRSTV 277 >3EB0-A nrPDB Length = 383 Score = 264 bits (674), Expect = 5e-71, Method: Composition-based stats. Identities = 100/366 (27%), Positives = 177/366 (48%), Gaps = 60/366 (16%) Query: 19 TIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLV 78 T +Y + +G+G+ GIVC +D + + A+KK+ + + RE +MK++ Sbjct: 4 TSSKKYSLGKTLGTGSFGIVCEVFDIESGKRFALKKV------LQDPRYKNRELDIMKVL 57 Query: 79 NHKNIIGLLNAFTPQRNLE--------------------------------EFQDVYLVM 106 +H NII L++ F + E + + + ++M Sbjct: 58 DHVNIIKLVDYFYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNVIM 117 Query: 107 ELMDANLCQVIQ------MDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKA- 159 E + L +V++ + + +S +YQ+ + +HS GI HRD+KP N++V + Sbjct: 118 EYVPDTLHKVLKSFIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLLVNSK 177 Query: 160 DCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILG-MGYTENVDIWSVGCIMGEMIR 218 D TLK+ DFG A+ + Y+ +R+YRAPE++LG YT ++D+WS+GC+ GE+I Sbjct: 178 DNTLKLCDFGSAKKLIPSEPSVAYICSRFYRAPELMLGATEYTPSIDLWSIGCVFGELIL 237 Query: 219 GGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLF 278 G LF G IDQ +II+ +GTP+ M R+ P P + ++ P+G Sbjct: 238 GKPLFSGETSIDQLVRIIQIMGTPTKEQMIRMNPHYTEV--RFPTLKAKDWRKILPEG-- 293 Query: 279 PNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEYINVWYDAEEVDAPAPEPYD 338 S A +LL ++L +P+ RI+ EA+ H + + ++ E + + Sbjct: 294 ----------TPSLAIDLLEQILRYEPDLRINPYEAMAHPFFDHLRNSYESEVKNNSNFP 343 Query: 339 HSVDER 344 H V++ Sbjct: 344 HGVNQN 349 >3E3P-A nrPDB Length = 360 Score = 264 bits (674), Expect = 5e-71, Method: Composition-based stats. Identities = 102/345 (29%), Positives = 163/345 (47%), Gaps = 27/345 (7%) Query: 22 SRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHK 81 R+ R G G G V + T +VAIKK+ Q+ R + + + +++H Sbjct: 23 DRFQVERMAGQGTFGTVQLGKEKSTGMSVAIKKV---IQDPRFRNRELQIMQDLAVLHHP 79 Query: 82 NIIGLLNAFTPQRNLEEFQDVYL--VMELMDANLCQ----VIQMDL--DHDRMSYLLYQM 133 NI+ L + F + +D+YL VME + L + + + + L+Q+ Sbjct: 80 NIVQLQSYFYTLGE-RDRRDIYLNVVMEYVPDTLHRCCRNYYRRQVAPPPILIKVFLFQL 138 Query: 134 LCGIKHLH--SAGIIHRDLKPSNIVVKA-DCTLKILDFGLARTAGTTFMMTPYVVTRYYR 190 + I LH S + HRD+KP N++V D TLK+ DFG A+ + Y+ +RYYR Sbjct: 139 IRSIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKLSPSEPNVAYICSRYYR 198 Query: 191 APEVILG-MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQR 249 APE+I G YT VDIWSVGCI EM+ G +F G + Q ++I+ LG PS +++ Sbjct: 199 APELIFGNQHYTTAVDIWSVGCIFAEMMLGEPIFRGDNSAGQLHEIVRVLGCPSREVLRK 258 Query: 250 LQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRI 309 L P+ + + G + +F D +S + A +A +LLS +L PE+R+ Sbjct: 259 LNPSHTDV--DLYNSKGIPWSNVFSD---------HSLKDAKEAYDLLSALLQYLPEERM 307 Query: 310 SVDEALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKEL 354 EAL H Y + +D + + + +E E Sbjct: 308 KPYEALCHPYFDELHDPATKLPNNKDLPEDLFRFLPNEIEVMSEA 352 >3ZDU-A nrPDB Length = 325 Score = 263 bits (673), Expect = 7e-71, Method: Composition-based stats. Identities = 95/305 (31%), Positives = 144/305 (47%), Gaps = 24/305 (7%) Query: 22 SRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHK 81 Y L +G G+ G V T Q VAIK + + K A RE K +K +H+ Sbjct: 3 EMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVN-KIAMREIKFLKQFHHE 61 Query: 82 NIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQM---DLDHDRMSYLLYQMLCGIK 138 N++ L+ F ++ + LV E +D + +Q L+ R+ L+Q+L I Sbjct: 62 NLVNLIEVFRQKKKIH------LVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAID 115 Query: 139 HLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTA-GTTFMMTPYVVTRYYRAPE-VIL 196 +LHS IIHRD+KP NI+V K+ DFG ART + V TR+YRAPE V+ Sbjct: 116 YLHSNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYDDEVATRWYRAPELVLK 175 Query: 197 GMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRN 256 Y + VDIW++GC++ EM G P + +D +KI+ ++G L P ++N Sbjct: 176 DTSYGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVG--------NLSPHLQN 227 Query: 257 YVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALK 316 P + G + P P + + + +++ L IDP RIS + L Sbjct: 228 IFSKSPIFAGV----VLPQVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLH 283 Query: 317 HEYIN 321 HEY Sbjct: 284 HEYFT 288 >3H4J-B nrPDB Length = 336 Score = 263 bits (673), Expect = 8e-71, Method: Composition-based stats. Identities = 88/354 (24%), Positives = 144/354 (40%), Gaps = 56/354 (15%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTH-AKRAYREFKLMKLVNHKN 82 YI +G G+ G V A TQQ VA+K +SR + R RE +KL+ H + Sbjct: 11 YIIRETLGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREISYLKLLRHPH 70 Query: 83 IIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVI--QMDLDHDRMSYLLYQMLCGIKHL 140 II L + T D+ +V+E L I + + D Q++C I++ Sbjct: 71 IIKLYDVITTP------TDIVMVIEYAGGELFDYIVEKKRMTEDEGRRFFQQIICAIEYC 124 Query: 141 HSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGY 200 H I+HRDLKP N+++ + +KI DFGL+ + + Y APEVI G Y Sbjct: 125 HRHKIVHRDLKPENLLLDDNLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVINGKLY 184 Query: 201 -TENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVE 259 VD+WS G ++ M+ G + F F+ L V + V Sbjct: 185 AGPEVDVWSCGIVLYVMLVGRLPFDD-------------------EFIPNLFKKVNSCVY 225 Query: 260 NRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEY 319 P + + A++L+ +M+V DP QRI++ E + + Sbjct: 226 VMPDF------------------------LSPGAQSLIRRMIVADPMQRITIQEIRRDPW 261 Query: 320 INVWYDAEEVDAPAPEPYDHSVDEREHT-VEQWKELIYEEVMDYEAHNTNNRTR 372 NV + + P E D R + + + + +++ + NN + Sbjct: 262 FNV--NLPDYLRPMEEVQGSYADSRIVSKLGEAMGFSEDYIVEALRSDENNEVK 313 >5IG1-A nrPDB Length = 344 Score = 263 bits (672), Expect = 9e-71, Method: Composition-based stats. Identities = 77/345 (22%), Positives = 129/345 (37%), Gaps = 72/345 (20%) Query: 29 PIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLN 88 IG GA V + T + A+K ++ + + RE + + H++I+ + Sbjct: 24 VIGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRSSEINKIKREIGICSSLQHEHIVSMRR 83 Query: 89 AFTPQRNLEEFQDVYLVMELMDAN-LCQVI--QMDLDHDRMSYLLYQMLCGIKHLHSAGI 145 AF + + YLV E + L I + + S ++Q+L ++H HS I Sbjct: 84 AFRDESHF------YLVFEYVSGGELFDEIVTRKFYNEKDASACMHQILSALQHCHSKNI 137 Query: 146 IHRDLKPSNIVV---KADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGYTE 202 IHRDLKP N+++ + +KI DFGLA + T Y +PEVI + Y Sbjct: 138 IHRDLKPENLLLASKDPNAPVKITDFGLAVIMEQGPTYFGFAGTPGYLSPEVIRRVPYDT 197 Query: 203 NVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENRP 262 VD+W+ G I+ ++ G F DH + +I Sbjct: 198 AVDVWACGVILYILLVGYPPFWEEDHQKLYAQI--------------------------- 230 Query: 263 RYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEYINV 322 + Y F D + A+ L+ ML +P++R +V E L+H +I Sbjct: 231 KNCQYDFPSPEWDS------------VTTAAKELIKAMLEPNPKRRPTVQELLQHPWIAR 278 Query: 323 WYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYEEVMDYEAHNT 367 V ++ EE+ + A Sbjct: 279 RDVPGSVH---------------------RQATLEELKKFNARRK 302 >3MN3-A nrPDB Length = 271 Score = 263 bits (671), Expect = 1e-70, Method: Composition-based stats. Identities = 74/314 (23%), Positives = 128/314 (40%), Gaps = 55/314 (17%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAK-RAYREFKLMKLVNHKN 82 Y ++ +G G+ G V AY T T Q VA+K +++ + + R RE ++L+ H + Sbjct: 6 YQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRHPH 65 Query: 83 IIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVI--QMDLDHDRMSYLLYQMLCGIKHL 140 II L + + ++ +V+E L I + + Q++ +++ Sbjct: 66 IIKLYDVIKSK------DEIIMVIEYAGNELFDYIVQRDKMSEQEARRFFQQIISAVEYC 119 Query: 141 HSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGY 200 H I+HRDLKP N+++ +KI DFGL+ + + Y APEVI G Y Sbjct: 120 HRHKIVHRDLKPENLLLDEHLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKLY 179 Query: 201 -TENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVE 259 VD+WS G I+ M+ + F + L + N V Sbjct: 180 AGPEVDVWSCGVILYVMLCRRLPFDDES-------------------IPVLFKNISNGVY 220 Query: 260 NRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEY 319 P++ + A L+ +ML+++P RIS+ E ++ ++ Sbjct: 221 TLPKF------------------------LSPGAAGLIKRMLIVNPLNRISIHEIMQDDW 256 Query: 320 INVWYDAEEVDAPA 333 V D E P Sbjct: 257 FKV--DLPEYLLPP 268 >4FG9-A nrPDB Length = 320 Score = 262 bits (669), Expect = 2e-70, Method: Composition-based stats. Identities = 75/308 (24%), Positives = 134/308 (43%), Gaps = 52/308 (16%) Query: 19 TIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLV 78 I Y +G+GA V A D TQ+ VAIK +++ E ++ + Sbjct: 15 DIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGS-MENEIAVLHKI 73 Query: 79 NHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN--LCQVIQMDL-DHDRMSYLLYQMLC 135 H NI+ L + + E +YL+M+L+ ++++ S L++Q+L Sbjct: 74 KHPNIVALDDIY------ESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLD 127 Query: 136 GIKHLHSAGIIHRDLKPSNIV---VKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAP 192 +K+LH GI+HRDLKP N++ + D + I DFGL++ +++ T Y AP Sbjct: 128 AVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAP 187 Query: 193 EVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQP 252 EV+ Y++ VD WS+G I ++ G F + + +I++ Sbjct: 188 EVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILK--------------- 232 Query: 253 TVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVD 312 Y FD + D + A++ + ++ DPE+R + + Sbjct: 233 ------------AEYEFDSPYWD------------DISDSAKDFIRHLMEKDPEKRFTCE 268 Query: 313 EALKHEYI 320 +AL+H +I Sbjct: 269 QALQHPWI 276 >4RED-A nrPDB Length = 351 Score = 262 bits (669), Expect = 2e-70, Method: Composition-based stats. Identities = 83/343 (24%), Positives = 127/343 (37%), Gaps = 54/343 (15%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSR-PFQNVTHAKRAYREFKLMKLVNHKN 82 YI +G G G V +T VA+K L+R +++ + RE + +KL H + Sbjct: 16 YILGDTLGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPH 75 Query: 83 IIGLLNAFTPQRNLEEFQDVYLVMELMDAN-LCQVI--QMDLDHDRMSYLLYQMLCGIKH 139 II L + D+++VME + L I LD L Q+L G+ + Sbjct: 76 IIKLYQVISTPS------DIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDY 129 Query: 140 LHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMG 199 H ++HRDLKP N+++ A KI DFGL+ + + Y APEVI G Sbjct: 130 CHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRL 189 Query: 200 Y-TENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYV 258 Y VDIWS G I+ ++ G + F + KI + + Sbjct: 190 YAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTP--------------- 234 Query: 259 ENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHE 318 + +LL ML +DP +R S+ + +HE Sbjct: 235 ----------------------------QYLNPSVISLLKHMLQVDPMKRASIKDIREHE 266 Query: 319 YINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYEEVMD 361 + DE V + E EEV+ Sbjct: 267 WFKQDLPKYLFPEDPSYSTTMIDDEALKEVCEKFECSEEEVLS 309 >4CFH-A nrPDB Length = 493 Score = 261 bits (667), Expect = 4e-70, Method: Composition-based stats. Identities = 82/343 (23%), Positives = 127/343 (37%), Gaps = 54/343 (15%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSR-PFQNVTHAKRAYREFKLMKLVNHKN 82 YI +G G G V +T VA+K L+R +++ + RE + +KL H + Sbjct: 35 YILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPH 94 Query: 83 IIGLLNAFTPQRNLEEFQDVYLVMELMDAN-LCQVI--QMDLDHDRMSYLLYQMLCGIKH 139 II L + D+++VME + L I LD L Q+L G+ + Sbjct: 95 IIKLYQVISTPS------DIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDY 148 Query: 140 LHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMG 199 H ++HRDLKP N+++ A KI DFGL+ + + Y APEVI G Sbjct: 149 CHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRL 208 Query: 200 Y-TENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYV 258 Y VDIWS G I+ ++ G + F + KI + + Sbjct: 209 YAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTP--------------- 253 Query: 259 ENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHE 318 + +LL ML +DP +R ++ + +HE Sbjct: 254 ----------------------------QYLNPSVISLLKHMLQVDPMKRATIKDIREHE 285 Query: 319 YINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYEEVMD 361 + DE V + E EEV+ Sbjct: 286 WFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLS 328 >2JC6-A nrPDB Length = 334 Score = 261 bits (666), Expect = 4e-70, Method: Composition-based stats. Identities = 69/308 (22%), Positives = 130/308 (42%), Gaps = 52/308 (16%) Query: 19 TIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLV 78 I + +G+GA V A + T + A+K + + + E +++ + Sbjct: 19 DIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESS-IENEIAVLRKI 77 Query: 79 NHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN--LCQVIQMDL-DHDRMSYLLYQMLC 135 H+NI+ L + + +L YLVM+L+ ++++ S L+ Q+L Sbjct: 78 KHENIVALEDIYESPNHL------YLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLD 131 Query: 136 GIKHLHSAGIIHRDLKPSNIVV---KADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAP 192 + +LH GI+HRDLKP N++ + + I DFGL++ G +M+ T Y AP Sbjct: 132 AVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAP 191 Query: 193 EVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQP 252 EV+ Y++ VD WS+G I ++ G F + + +I++ Sbjct: 192 EVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILK--------------- 236 Query: 253 TVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVD 312 Y FD + D + A++ + ++ DP +R + + Sbjct: 237 ------------AEYEFDSPYWD------------DISDSAKDFIRNLMEKDPNKRYTCE 272 Query: 313 EALKHEYI 320 +A +H +I Sbjct: 273 QAARHPWI 280 >6C9D-A nrPDB Length = 459 Score = 260 bits (664), Expect = 8e-70, Method: Composition-based stats. Identities = 75/342 (21%), Positives = 135/342 (39%), Gaps = 54/342 (15%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNI 83 Y + IG G V A +T + VA+K + + N T ++ +RE ++MK++NH NI Sbjct: 23 YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNI 82 Query: 84 IGLLNAFTPQRNLEEFQDVYLVMELMDAN---LCQVIQMDLDHDRMSYLLYQMLCGIKHL 140 + L ++ L YLVME V + Q++ +++ Sbjct: 83 VKLFEVIETEKTL------YLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYC 136 Query: 141 HSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGY 200 H I+HRDLK N+++ D +KI DFG + + + + Y APE+ G Y Sbjct: 137 HQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDEFCGSPPYAAPELFQGKKY 196 Query: 201 T-ENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVE 259 VD+WS+G I+ ++ G + F G + + +++ R + + Y+ Sbjct: 197 DGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVL------------RGKYRIPFYMS 244 Query: 260 NRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEY 319 L P +R S+++ +K + Sbjct: 245 TDCENLLKKLLVLNPI-------------------------------KRGSLEQIMKDRW 273 Query: 320 INVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYEEVMD 361 +NV ++ EE+ P EP D + + +E+ D Sbjct: 274 MNVGHEEEEL-KPYTEPDPDFNDTKRIDIMVTMGFARDEIND 314 >2HAK-A nrPDB Length = 328 Score = 259 bits (663), Expect = 1e-69, Method: Composition-based stats. Identities = 75/342 (21%), Positives = 135/342 (39%), Gaps = 54/342 (15%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNI 83 Y + IG G V A +T + VA+K + + N T ++ +RE ++MK++NH NI Sbjct: 17 YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNI 76 Query: 84 IGLLNAFTPQRNLEEFQDVYLVMELMDAN---LCQVIQMDLDHDRMSYLLYQMLCGIKHL 140 + L ++ L YLVME V + Q++ +++ Sbjct: 77 VKLFEVIETEKTL------YLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYC 130 Query: 141 HSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGY 200 H I+HRDLK N+++ D +KI DFG + + + + Y APE+ G Y Sbjct: 131 HQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKY 190 Query: 201 T-ENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVE 259 VD+WS+G I+ ++ G + F G + + +++ R + + Y+ Sbjct: 191 DGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVL------------RGKYRIPFYMS 238 Query: 260 NRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEY 319 L P +R S+++ +K + Sbjct: 239 TDCENLLKKLLVLNPI-------------------------------KRGSLEQIMKDRW 267 Query: 320 INVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYEEVMD 361 +NV ++ EE+ P EP D + + +E+ D Sbjct: 268 MNVGHEEEEL-KPYTEPDPDFNDTKRIDIMVTMGFARDEIND 308 >5XZW-A nrPDB Length = 471 Score = 258 bits (659), Expect = 3e-69, Method: Composition-based stats. Identities = 82/326 (25%), Positives = 136/326 (41%), Gaps = 64/326 (19%) Query: 13 VGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREF 72 V + I +G GA V A + T + A+K +S+ + + + RE Sbjct: 187 VANKTGIFKDFSIIDEVVGQGAFATVKKAIERTTGKTFAVKIISKR-KVIGNMDGVTREL 245 Query: 73 KLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELM-DANLCQVI--QMDLDHDRMSYL 129 ++++ +NH I+ L + E+ + Y+VME + +L + + D + Sbjct: 246 EVLQKLNHPRIVRLKGFY------EDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREI 299 Query: 130 LYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCT--LKILDFGLARTAGTTFMMTPYVVTR 187 Q+L IK++HS GI HRDLKP NI+++ D +KI DFGLA+ G M + T Sbjct: 300 SRQILTAIKYIHSMGISHRDLKPDNILIEQDDPVLVKITDFGLAKVQGNGSFMKTFCGTL 359 Query: 188 YYRAPEVILGMG-------------YTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNK 234 Y APEVI G Y+ VD+WS+GC++ ++ G + F G+ + + Sbjct: 360 AYVAPEVIRGKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQ 419 Query: 235 IIEQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDAR 294 I R Y R + +AR Sbjct: 420 I------------------------GRGSYHEGPLKDF---------------RISEEAR 440 Query: 295 NLLSKMLVIDPEQRISVDEALKHEYI 320 + + +L +DP R + +AL H +I Sbjct: 441 DFIDSLLQVDPNNRSTAAKALNHPWI 466 >3Q5I-A nrPDB Length = 504 Score = 258 bits (658), Expect = 4e-69, Method: Composition-based stats. Identities = 82/321 (25%), Positives = 132/321 (41%), Gaps = 63/321 (19%) Query: 20 IHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQN-----------VTHAKRA 68 I Y +R +GSGA G V + AIK + + + + Sbjct: 34 IGESYFKVRKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYSDDNKNIEKFHEEI 93 Query: 69 YREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN-LCQVI--QMDLDHDR 125 Y E L+K ++H NII L + F ++ YLV E + L + I + D Sbjct: 94 YNEISLLKSLDHPNIIKLFDVFEDKKYF------YLVTEFYEGGELFEQIINRHKFDECD 147 Query: 126 MSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADC---TLKILDFGLARTAGTTFMMTP 182 + ++ Q+L GI +LH I+HRD+KP NI+++ +KI+DFGL+ + + Sbjct: 148 AANIMKQILSGICYLHKHNIVHRDIKPENILLENKNSLLNIKIVDFGLSSFFSKDYKLRD 207 Query: 183 YVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTP 242 + T YY APEV+ Y E D+WS G IM ++ G F G + D K+ + Sbjct: 208 RLGTAYYIAPEVLK-KKYNEKCDVWSCGVIMYILLCGYPPFGGQNDQDIIKKVEK----- 261 Query: 243 SPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLV 302 Y FD + + + +A+ L+ ML Sbjct: 262 ----------------------GKYYFD------------FNDWKNISDEAKELIKLMLT 287 Query: 303 IDPEQRISVDEALKHEYINVW 323 D +R + +EAL +I + Sbjct: 288 YDYNKRCTAEEALNSRWIKKY 308 >2YCR-A nrPDB Length = 323 Score = 257 bits (656), Expect = 7e-69, Method: Composition-based stats. Identities = 89/318 (27%), Positives = 143/318 (44%), Gaps = 60/318 (18%) Query: 20 IHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRA------YREFK 73 + YI + +GSGA G V A++ T + VAIK +S+ + A+ A E + Sbjct: 8 LRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIE 67 Query: 74 LMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN-LCQVI--QMDLDHDRMSYLL 130 ++K +NH II + N F + +D Y+V+ELM+ L + L Sbjct: 68 ILKKLNHPCIIKIKNFF-------DAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYF 120 Query: 131 YQMLCGIKHLHSAGIIHRDLKPSNIVVK---ADCTLKILDFGLARTAGTTFMMTPYVVTR 187 YQML +++LH GIIHRDLKP N+++ DC +KI DFG ++ G T +M T Sbjct: 121 YQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTP 180 Query: 188 YYRAPEVILG---MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSP 244 Y APEV++ GY VD WS+G I+ + G F + +Q+ + Sbjct: 181 TYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPF---SEHRTQVSLKDQITSGKY 237 Query: 245 SFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVID 304 +F+ + + A +L+ K+LV+D Sbjct: 238 NFIPEV-----------------------------------WAEVSEKALDLVKKLLVVD 262 Query: 305 PEQRISVDEALKHEYINV 322 P+ R + +EAL+H ++ Sbjct: 263 PKARFTTEEALRHPWLQD 280 >3COM-A nrPDB Length = 314 Score = 257 bits (656), Expect = 7e-69, Method: Composition-based stats. Identities = 68/302 (22%), Positives = 121/302 (40%), Gaps = 55/302 (18%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNI 83 + L +G G+ G V A T Q VAIK++ + + +E +M+ + ++ Sbjct: 31 FDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPV----ESDLQEIIKEISIMQQCDSPHV 86 Query: 84 IGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQ---MDLDHDRMSYLLYQMLCGIKH 139 + ++ D+++VME ++ +I+ L D ++ +L L G+++ Sbjct: 87 VKYYGSYFKN------TDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEY 140 Query: 140 LHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTF-MMTPYVVTRYYRAPEVILGM 198 LH IHRD+K NI++ + K+ DFG+A T + T ++ APEVI + Sbjct: 141 LHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEI 200 Query: 199 GYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYV 258 GY DIWS+G EM G + I I P P+F Sbjct: 201 GYNCVADIWSLGITAIEMAEGKPPYAD---IHPMRAIFMIPTNPPPTF------------ 245 Query: 259 ENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHE 318 + + + + + + LV PEQR + + L+H Sbjct: 246 -------------------------RKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHP 280 Query: 319 YI 320 ++ Sbjct: 281 FV 282 >6FD3-A nrPDB Length = 300 Score = 255 bits (652), Expect = 2e-68, Method: Composition-based stats. Identities = 79/315 (25%), Positives = 134/315 (42%), Gaps = 55/315 (17%) Query: 11 VEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYR 70 V VGD +Y IG GA G V A D T Q VAIK+++ Q + Sbjct: 15 VSVGDPK----KKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMN--LQQQPKKELIIN 68 Query: 71 EFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQ--VIQMDLDHDRMSY 128 E +M+ + NI+ L+++ ++++VME + V + +D +++ Sbjct: 69 EILVMRENKNPNIVNYLDSYLV------GDELWVVMEYLAGGSLTDVVTETCMDEGQIAA 122 Query: 129 LLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGL-ARTAGTTFMMTPYVVTR 187 + + L + LHS +IHRD+K NI++ D ++K+ DFG A+ + V T Sbjct: 123 VCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTP 182 Query: 188 YYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFM 247 Y+ APEV+ Y VDIWS+G + EM+ G + + + I GTP Sbjct: 183 YWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATN-GTPELQNP 241 Query: 248 QRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQ 307 +RL ++ R+ L++ L +D ++ Sbjct: 242 ERL---------------------------------------SAVFRDFLNRCLEMDVDR 262 Query: 308 RISVDEALKHEYINV 322 R S E L+H ++ + Sbjct: 263 RGSAKELLQHPFLKL 277 >3TAC-A nrPDB Length = 361 Score = 254 bits (650), Expect = 3e-68, Method: Composition-based stats. Identities = 74/328 (22%), Positives = 132/328 (40%), Gaps = 60/328 (18%) Query: 10 TVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVT---HAK 66 + D + Y IG G +V + T Q A+K + + + Sbjct: 14 RGSMADDDVLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTE 73 Query: 67 RAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDA-NLCQVIQMDLD--- 122 RE + ++ H +I+ LL ++ L Y+V E MD +LC I D Sbjct: 74 DLKREASICHMLKHPHIVELLETYSSDGML------YMVFEFMDGADLCFEIVKRADAGF 127 Query: 123 ---HDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKA---DCTLKILDFGLARTAGT 176 S+ + Q+L +++ H IIHRD+KP +++ + +K+ FG+A G Sbjct: 128 VYSEAVASHYMRQILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGE 187 Query: 177 TFMMTP-YVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKI 235 + ++ V T ++ APEV+ Y + VD+W G I+ ++ G + F GT + I Sbjct: 188 SGLVAGGRVGTPHFMAPEVVKREPYGKPVDVWGCGVILFILLSGCLPFYGTKER-LFEGI 246 Query: 236 IEQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARN 295 I+ +P + + A++ Sbjct: 247 IKGKYKMNP---------------------------------------RQWSHISESAKD 267 Query: 296 LLSKMLVIDPEQRISVDEALKHEYINVW 323 L+ +ML++DP +RI+V EAL H ++ Sbjct: 268 LVRRMLMLDPAERITVYEALNHPWLKER 295 >4NIF-A nrPDB Length = 333 Score = 254 bits (650), Expect = 4e-68, Method: Composition-based stats. Identities = 76/316 (24%), Positives = 136/316 (43%), Gaps = 57/316 (18%) Query: 16 TNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLM 75 +N Y+ IG G+ T A+K + + ++ + E +++ Sbjct: 2 SNLVFSDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSE------EIEIL 55 Query: 76 -KLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN--LCQVIQMDL-DHDRMSYLLY 131 + H NII L + + ++ + VYLV ELM L ++++ S++L+ Sbjct: 56 LRYGQHPNIITLKDVY------DDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLH 109 Query: 132 QMLCGIKHLHSAGIIHRDLKPSNIV-VKADCT---LKILDFGLARTA-GTTFMMTPYVVT 186 + +++LHS G++HRDLKPSNI+ V L+I DFG A+ ++ T Sbjct: 110 TIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYT 169 Query: 187 RYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSF 246 + APEV+ GY E DIWS+G ++ M+ G F D +I+ ++G+ + Sbjct: 170 ANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTPF-ANGPSDTPEEILTRIGSGKFTL 228 Query: 247 MQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPE 306 + N + A++L+SKML +DP Sbjct: 229 -----------------------------------SGGNWNTVSETAKDLVSKMLHVDPH 253 Query: 307 QRISVDEALKHEYINV 322 QR++ + L+H ++ Sbjct: 254 QRLTAKQVLQHPWVTQ 269 >5WAX-A nrPDB Length = 310 Score = 253 bits (647), Expect = 8e-68, Method: Composition-based stats. Identities = 76/343 (22%), Positives = 133/343 (38%), Gaps = 52/343 (15%) Query: 21 HSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNH 80 RY +R IGSG G+ + Q VA+K + R + RE + + H Sbjct: 10 GDRYELVRDIGSGNFGVARLMRNRADGQLVAVKYIER---GEKIDENVQREIINHRSLRH 66 Query: 81 KNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN-LCQVI--QMDLDHDRMSYLLYQMLCGI 137 NII +L +VME L + I D + Q++ G+ Sbjct: 67 PNIIRFKEVILTPTHLA------IVMEYASGGELFERICNAGRFSEDEARFFFQQLISGV 120 Query: 138 KHLHSAGIIHRDLKPSNIVVKADC--TLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVI 195 + HS + HRDLK N ++ LKI DFG ++++ V T Y APEV+ Sbjct: 121 SYCHSMQVCHRDLKLENTLLDGSTAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVL 180 Query: 196 LGMGYTENV-DIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTV 254 L Y V D+WS G + M+ G F D + K I+++ +Q ++ Sbjct: 181 LKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRILG--------VQYSI 232 Query: 255 RNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEA 314 +YV + + ++L+S++ V +P RI++ E Sbjct: 233 PDYV-----------------------------HISPECQDLISRIFVANPATRITIPEI 263 Query: 315 LKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYE 357 H + A+ +D ++ ++++ +++ E Sbjct: 264 RNHPWFLKNLPADLMDDSTMSKQYEEPEQPMQSMDEIMQILAE 306 >4CZT-A nrPDB Length = 464 Score = 252 bits (645), Expect = 1e-67, Method: Composition-based stats. Identities = 80/346 (23%), Positives = 135/346 (39%), Gaps = 63/346 (18%) Query: 22 SRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSR-PFQNVTHAKRAYREFKLMKLVNH 80 +Y R +G G V A + NVAIK + + + RE MKL+ H Sbjct: 11 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH 70 Query: 81 KNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN-LCQVIQM--DLDHDRMSYLLYQMLCGI 137 N+I + + +Y V+E + L I L D Q++ + Sbjct: 71 PNVIRMFEV------MASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAV 124 Query: 138 KHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLA---RTAGTTFMMTPYVVTRYYRAPEV 194 + HS G+ HRDLKP N+++ A+ LK+ DFGL+ + ++ T Y APEV Sbjct: 125 DYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEV 184 Query: 195 ILGMGYT-ENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPT 253 I GY D+WS G I+ ++ G + F ++ + KI + T P F Sbjct: 185 INNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWF------- 237 Query: 254 VRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDE 313 ++ A+ L+ ++L +P RI+ E Sbjct: 238 ------------------------------------SASAKKLIKRILDPNPATRITFAE 261 Query: 314 ALKHEYINVWY------DAEEVDAPAPEPYDHSVDEREHTVEQWKE 353 +++E+ Y +A+ +D S + + VE+ +E Sbjct: 262 VIENEWFKKGYKAPKFENADVSLDDVDAIFDDSGESKNLVVERREE 307 >5ZTN-A nrPDB Length = 429 Score = 252 bits (645), Expect = 1e-67, Method: Composition-based stats. Identities = 91/345 (26%), Positives = 156/345 (45%), Gaps = 33/345 (9%) Query: 3 TAQHQHYTVEVGD----TNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRP 58 + Y + G + + RY L+ IG G+ G V AYD Q+VA+K + Sbjct: 74 GPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVR-- 131 Query: 59 FQNVTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQ 118 ++A E ++++ + ++ +N N + + EL+ NL ++I+ Sbjct: 132 -NEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIK 190 Query: 119 MD----LDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCT--LKILDFGLAR 172 + + + +L + LH IIH DLKP NI++K +K++DFG + Sbjct: 191 KNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSC 250 Query: 173 TAGTTFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQW 232 + Y+ +R+YRAPEVILG Y +D+WS+GCI+ E++ G L PG D DQ Sbjct: 251 Y--EHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQL 308 Query: 233 NKIIEQLGTPSPSFMQRLQPTVRNYVENR--PRYTGYSFDRLFPDGLFPNDNNQNSRRKA 290 +IE LG PS + +N+V ++ PRY + L + + R Sbjct: 309 ACMIELLGMPSQKLL-DASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGP 367 Query: 291 SDAR---------------NLLSKMLVIDPEQRISVDEALKHEYI 320 ++R + L + L DP R++ +AL+H ++ Sbjct: 368 PESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWL 412 >4LG4-A nrPDB Length = 299 Score = 252 bits (645), Expect = 1e-67, Method: Composition-based stats. Identities = 69/303 (22%), Positives = 121/303 (39%), Gaps = 55/303 (18%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNI 83 + L +G G+ G V A + Q VAIK++ + + +E +M+ + + Sbjct: 13 FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPV----ESDLQEIIKEISIMQQCDSPYV 68 Query: 84 IGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQ---MDLDHDRMSYLLYQMLCGIKH 139 + ++ D+++VME ++ +I+ L D ++ +L L G+++ Sbjct: 69 VKYYGSYFKN------TDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEY 122 Query: 140 LHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTF-MMTPYVVTRYYRAPEVILGM 198 LH IHR++K NI++ + K+ DFG+A T + T ++ APEVI + Sbjct: 123 LHFMRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEI 182 Query: 199 GYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYV 258 GY DIWS+G EM G + I I P P+F Sbjct: 183 GYNCVADIWSLGITSIEMAEGKPPYAD---IHPMRAIFMIPTNPPPTF------------ 227 Query: 259 ENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHE 318 + + D + + K LV +PEQR + + L+H Sbjct: 228 -------------------------RKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHP 262 Query: 319 YIN 321 +I Sbjct: 263 FIK 265 >4JG6-A nrPDB Length = 355 Score = 252 bits (644), Expect = 2e-67, Method: Composition-based stats. Identities = 82/347 (23%), Positives = 142/347 (40%), Gaps = 64/347 (18%) Query: 1 MTTAQHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQ 60 M T ++ + Y IG G+ + T A+K + + + Sbjct: 14 MQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKR 73 Query: 61 NVTHAKRAYREFKLM-KLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN--LCQVI 117 + T E +++ + H NII L + + ++ + VY+V ELM L +++ Sbjct: 74 DPTE------EIEILLRYGQHPNIITLKDVY------DDGKYVYVVTELMKGGELLDKIL 121 Query: 118 QMDL-DHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIV-VKADCT---LKILDFGLAR 172 + S +L+ + +++LH+ G++HRDLKPSNI+ V ++I DFG A+ Sbjct: 122 RQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAK 181 Query: 173 TA-GTTFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFP-GTDHID 230 ++ T + APEV+ GY DIWS+G ++ M+ G F G D D Sbjct: 182 QLRAENGLLMTPCYTANFVAPEVLERQGYDAACDIWSLGVLLYTMLTGYTPFANGPD--D 239 Query: 231 QWNKIIEQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKA 290 +I+ ++G+ S + + Sbjct: 240 TPEEILARIGSGKFSL-----------------------------------SGGYWNSVS 264 Query: 291 SDARNLLSKMLVIDPEQRISVDEALKHEYINVW-----YDAEEVDAP 332 A++L+SKML +DP QR++ L+H +I W Y DAP Sbjct: 265 DTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAP 311 >3I6U-A nrPDB Length = 419 Score = 252 bits (644), Expect = 2e-67, Method: Composition-based stats. Identities = 88/318 (27%), Positives = 143/318 (44%), Gaps = 60/318 (18%) Query: 20 IHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRA------YREFK 73 + YI + +GSGA G V A++ T + VAI+ +S+ + A+ A E + Sbjct: 133 LRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSAREADPALNVETEIE 192 Query: 74 LMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN-LCQVI--QMDLDHDRMSYLL 130 ++K +NH II + N F + +D Y+V+ELM+ L + L Sbjct: 193 ILKKLNHPCIIKIKNFF-------DAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYF 245 Query: 131 YQMLCGIKHLHSAGIIHRDLKPSNIVVK---ADCTLKILDFGLARTAGTTFMMTPYVVTR 187 YQML +++LH GIIHRDLKP N+++ DC +KI DFG ++ G T +M T Sbjct: 246 YQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTP 305 Query: 188 YYRAPEVILG---MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSP 244 Y APEV++ GY VD WS+G I+ + G F + +Q+ + Sbjct: 306 TYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPF---SEHRTQVSLKDQITSGKY 362 Query: 245 SFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVID 304 +F+ + + A +L+ K+LV+D Sbjct: 363 NFIPEV-----------------------------------WAEVSEKALDLVKKLLVVD 387 Query: 305 PEQRISVDEALKHEYINV 322 P+ R + +EAL+H ++ Sbjct: 388 PKARFTTEEALRHPWLQD 405 >4PDS-A nrPDB Length = 347 Score = 251 bits (640), Expect = 5e-67, Method: Composition-based stats. Identities = 80/328 (24%), Positives = 136/328 (41%), Gaps = 64/328 (19%) Query: 13 VGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREF 72 V + I +G GA V A + T + ++K +S+ + + + RE Sbjct: 22 VANKTGIFKDFSIIDEVVGQGAFATVKKAIERTTGKTFSVKIISKR-KVIGNMDGVTREL 80 Query: 73 KLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELM-DANLCQVI--QMDLDHDRMSYL 129 ++++ +NH I+ L + E+ + Y+VME + +L + + D + Sbjct: 81 EVLQKLNHPRIVRLKGFY------EDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREI 134 Query: 130 LYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCT--LKILDFGLARTAGTTFMMTPYVVTR 187 Q+L IK++HS GI HRDLKP NI+++ D +KI FGLA+ G M + T Sbjct: 135 SRQILTAIKYIHSMGISHRDLKPDNILIEQDDPVLVKITAFGLAKVQGNGSFMKTFCGTL 194 Query: 188 YYRAPEVILGMG-------------YTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNK 234 Y APEVI G Y+ VD+WS+GC++ ++ G + F G+ + + Sbjct: 195 AYVAPEVIRGKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQ 254 Query: 235 IIEQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDAR 294 I R Y R + +AR Sbjct: 255 I------------------------GRGSYHEGPLKDF---------------RISEEAR 275 Query: 295 NLLSKMLVIDPEQRISVDEALKHEYINV 322 + + +L +DP R + +AL H +I + Sbjct: 276 DFIDSLLQVDPNNRSTAAKALNHPWIKM 303 >6AO5-A nrPDB Length = 362 Score = 250 bits (639), Expect = 6e-67, Method: Composition-based stats. Identities = 69/303 (22%), Positives = 121/303 (39%), Gaps = 55/303 (18%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNI 83 + L +G G+ G V A + Q VAIK++ + + +E +M+ + + Sbjct: 12 FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPV----ESDLQEIIKEISIMQQCDSPYV 67 Query: 84 IGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQ---MDLDHDRMSYLLYQMLCGIKH 139 + ++ D+++VME ++ +I+ L D ++ +L L G+++ Sbjct: 68 VKYYGSYFKN------TDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEY 121 Query: 140 LHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTF-MMTPYVVTRYYRAPEVILGM 198 LH IHR++K NI++ + K+ DFG+A T + T ++ APEVI + Sbjct: 122 LHFMRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEI 181 Query: 199 GYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYV 258 GY DIWS+G EM G + I I P P+F Sbjct: 182 GYNCVADIWSLGITSIEMAEGKPPYAD---IHPMRAIFMIPTNPPPTF------------ 226 Query: 259 ENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHE 318 + + D + + K LV +PEQR + + L+H Sbjct: 227 -------------------------RKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHP 261 Query: 319 YIN 321 +I Sbjct: 262 FIK 264 >2J90-A nrPDB Length = 304 Score = 250 bits (638), Expect = 8e-67, Method: Composition-based stats. Identities = 75/326 (23%), Positives = 129/326 (39%), Gaps = 60/326 (18%) Query: 11 VEVGDTNFTIHSR----YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHA- 65 V++G N S Y +GSG IV T + A K + + + + Sbjct: 11 VDLGTENLYFQSMVEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRG 70 Query: 66 ---KRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN-LCQVI--QM 119 + RE +++ + H NII L + F E DV L++EL+ L + + Sbjct: 71 VSREEIEREVNILREIRHPNIITLHDIF------ENKTDVVLILELVSGGELFDFLAEKE 124 Query: 120 DLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKA----DCTLKILDFGLARTAG 175 L D + L Q+L G+ +LHS I H DLKP NI++ + +K++DFG+A Sbjct: 125 SLTEDEATQFLKQILDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIE 184 Query: 176 TTFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKI 235 T + APE++ D+WS+G I ++ G F G + I Sbjct: 185 AGNEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNI 244 Query: 236 IEQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARN 295 Y FD + + A++ Sbjct: 245 ---------------------------SAVNYDFDE------------EYFSNTSELAKD 265 Query: 296 LLSKMLVIDPEQRISVDEALKHEYIN 321 + ++LV DP++R+++ ++L+H +I Sbjct: 266 FIRRLLVKDPKRRMTIAQSLEHSWIK 291 >2JAM-A nrPDB Length = 304 Score = 249 bits (636), Expect = 1e-66, Method: Composition-based stats. Identities = 78/350 (22%), Positives = 139/350 (39%), Gaps = 58/350 (16%) Query: 20 IHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVN 79 I +I + +GSGA V +T + A+K + + + E ++K + Sbjct: 7 IRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDSS--LENEIAVLKKIK 64 Query: 80 HKNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN-LCQVI--QMDLDHDRMSYLLYQMLCG 136 H+NI+ L + + E YLVM+L+ L I + S ++ Q+L Sbjct: 65 HENIVTLEDIY------ESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSA 118 Query: 137 IKHLHSAGIIHRDLKPSNIVV---KADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPE 193 +K+LH GI+HRDLKP N++ + + + I DFGL++ +M+ T Y APE Sbjct: 119 VKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSK-MEQNGIMSTACGTPGYVAPE 177 Query: 194 VILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPT 253 V+ Y++ VD WS+G I ++ G F + KI E Sbjct: 178 VLAQKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGY-------------- 223 Query: 254 VRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDE 313 Y F+ F D + A++ + +L DP +R + ++ Sbjct: 224 -------------YEFESPFWD------------DISESAKDFICHLLEKDPNERYTCEK 258 Query: 314 ALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYEEVMDYE 363 AL H +I+ P+ ++ +W++ + + Sbjct: 259 ALSHPWIDGNTALHRDIYPSVSLQI----QKNFAKSKWRQAFNAAAVVHH 304 >4KS7-A nrPDB Length = 292 Score = 248 bits (634), Expect = 2e-66, Method: Composition-based stats. Identities = 74/320 (23%), Positives = 141/320 (44%), Gaps = 55/320 (17%) Query: 4 AQHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVT 63 V+ GD + S Y+ IG G+ GIVC A + + + VA+K + + Sbjct: 9 KAALRMVVDQGDPRLLLDS-YV---KIGEGSTGIVCLAREKHSGRQVAVKMMD--LRKQQ 62 Query: 64 HAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVI--QMDL 121 + + E +M+ H N++ + ++ ++++++ME + I Q+ L Sbjct: 63 RRELLFNEVVIMRDYQHFNVVEMYKSYLV------GEELWVLMEFLQGGALTDIVSQVRL 116 Query: 122 DHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGL-ARTAGTTFMM 180 + ++++ + +L + +LH+ G+IHRD+K +I++ D +K+ DFG A+ + Sbjct: 117 NEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKR 176 Query: 181 TPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLG 240 V T Y+ APEVI Y VDIWS+G ++ EM+ G + + ++ + Sbjct: 177 KSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRD--- 233 Query: 241 TPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKM 300 +P P +NS + + R+ L +M Sbjct: 234 SPPPKL-------------------------------------KNSHKVSPVLRDFLERM 256 Query: 301 LVIDPEQRISVDEALKHEYI 320 LV DP++R + E L H ++ Sbjct: 257 LVRDPQERATAQELLDHPFL 276 >2YZA-A nrPDB Length = 276 Score = 248 bits (633), Expect = 3e-66, Method: Composition-based stats. Identities = 75/304 (24%), Positives = 119/304 (39%), Gaps = 54/304 (17%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSR-PFQNVTHAKRAYREFKLMKLVNHKN 82 Y+ +G G G V +T VA+K L+R +++ + RE + +KL H + Sbjct: 13 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 72 Query: 83 IIGLLNAFTPQRNLEEFQDVYLVMELMDAN-LCQVI--QMDLDHDRMSYLLYQMLCGIKH 139 II L + D ++VME + L I ++ L Q+L + + Sbjct: 73 IIKLYQVISTP------TDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDY 126 Query: 140 LHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMG 199 H ++HRDLKP N+++ A KI DFGL+ + + Y APEVI G Sbjct: 127 CHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRDSCGSPNYAAPEVISGRL 186 Query: 200 Y-TENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYV 258 Y VDIWS G I+ ++ G + F +H+ K I P ++ R T Sbjct: 187 YAGPEVDIWSCGVILYALLCGTLPF-DDEHVPTLFKKIRGGVFYIPEYLNRSVAT----- 240 Query: 259 ENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHE 318 LL ML +DP +R ++ + +HE Sbjct: 241 -------------------------------------LLMHMLQVDPLKRATIKDIREHE 263 Query: 319 YINV 322 + Sbjct: 264 WFKQ 267 >3F3Z-A nrPDB Length = 277 Score = 247 bits (630), Expect = 7e-66, Method: Composition-based stats. Identities = 84/315 (26%), Positives = 128/315 (40%), Gaps = 54/315 (17%) Query: 14 GDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFK 73 G T I+ Y IG G+ G V A T+ A KK+ + F V R +E + Sbjct: 1 GSTKGDINQYYTLENTIGRGSWGEVKIAVQKGTRIRRAAKKIPKYF--VEDVDRFKQEIE 58 Query: 74 LMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN--LCQVIQMD-LDHDRMSYLL 130 +MK ++H NII L F E+ D+YLVMEL +V+ + ++ Sbjct: 59 IMKSLDHPNIIRLYETF------EDNTDIYLVMELCTGGELFERVVHKRVFRESDAARIM 112 Query: 131 YQMLCGIKHLHSAGIIHRDLKPSNIVV---KADCTLKILDFGLARTAGTTFMMTPYVVTR 187 +L + + H + HRDLKP N + D LK++DFGLA MM V T Sbjct: 113 KDVLSAVAYCHKLNVAHRDLKPENFLFLTDSPDSPLKLIDFGLAARFKPGKMMRTKVGTP 172 Query: 188 YYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFM 247 YY +P+V+ G+ Y D WS G +M ++ G F + KI E T Sbjct: 173 YYVSPQVLEGL-YGPECDEWSAGVMMYVLLCGYPPFSAPTDSEVMLKIREGTFTFPE--- 228 Query: 248 QRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQ 307 ++ + A +L+ ++L P+Q Sbjct: 229 ------------------------------------KDWLNVSPQAESLIRRLLTKSPKQ 252 Query: 308 RISVDEALKHEYINV 322 RI+ +AL+HE+ Sbjct: 253 RITSLQALEHEWFEK 267 >2W4O-A nrPDB Length = 349 Score = 246 bits (629), Expect = 1e-65, Method: Composition-based stats. Identities = 77/314 (24%), Positives = 127/314 (40%), Gaps = 54/314 (17%) Query: 14 GDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFK 73 G + + +G GA IV TQ+ A+K L + K E Sbjct: 45 GSNRDALSDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDK----KIVRTEIG 100 Query: 74 LMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN-LCQVI--QMDLDHDRMSYLL 130 ++ ++H NII L F ++ LV+EL+ L I + + + Sbjct: 101 VLLRLSHPNIIKLKEIFETP------TEISLVLELVTGGELFDRIVEKGYYSERDAADAV 154 Query: 131 YQMLCGIKHLHSAGIIHRDLKPSNIVVKA---DCTLKILDFGLARTAGTTFMMTPYVVTR 187 Q+L + +LH GI+HRDLKP N++ D LKI DFGL++ +M T Sbjct: 155 KQILEAVAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTP 214 Query: 188 YYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFM 247 Y APE++ G Y VD+WSVG I ++ G F Sbjct: 215 GYCAPEILRGCAYGPEVDMWSVGIITYILLCGFEPFYDERGDQ----------------- 257 Query: 248 QRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQ 307 ++ R Y F + D + +A++L+ K++V+DP++ Sbjct: 258 ---------FMFRRILNCEYYFISPWWD------------EVSLNAKDLVRKLIVLDPKK 296 Query: 308 RISVDEALKHEYIN 321 R++ +AL+H ++ Sbjct: 297 RLTTFQALQHPWVT 310 >4D28-A nrPDB Length = 446 Score = 246 bits (629), Expect = 1e-65, Method: Composition-based stats. Identities = 80/324 (24%), Positives = 123/324 (37%), Gaps = 55/324 (16%) Query: 22 SRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRP-FQNVTHAKRAYREFKLMKLVNH 80 +Y R IG G V A +T T NVAIK +++ + RE +MK+V H Sbjct: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 Query: 81 KNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN-LCQVI--QMDLDHDRMSYLLYQMLCGI 137 NI+ L L +Y+V+E + L I + L D Q++ + Sbjct: 69 PNIVRLYEV------LASKSKIYIVLEFVTGGELFDRIVHKGRLKEDESRKYFQQLVDAV 122 Query: 138 KHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTT-FMMTPYVVTRYYRAPEVIL 196 H HS G+ HRDLKP N+++ + LK+ DFGL+ ++ T Y APEV+ Sbjct: 123 AHCHSKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLNDTCGTPNYVAPEVLS 182 Query: 197 GMGYT-ENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVR 255 G GY DIWS G I+ ++ G + F TD + KI P F Sbjct: 183 GQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFDCPPWF--------- 233 Query: 256 NYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEAL 315 +++ + L+ ++L +P+ RI + Sbjct: 234 ----------------------------------SAEVKFLIHRILDPNPKTRIQIQGIK 259 Query: 316 KHEYINVWYDAEEVDAPAPEPYDH 339 K + Y D Sbjct: 260 KDPWFRKNYVPIRAREEEEVNLDD 283 >2F57-A nrPDB Length = 317 Score = 246 bits (628), Expect = 1e-65, Method: Composition-based stats. Identities = 70/297 (23%), Positives = 132/297 (44%), Gaps = 51/297 (17%) Query: 29 PIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLN 88 IG G+ GIVC A + T + VA+KK+ + + + E +M+ +H N++ + + Sbjct: 52 KIGEGSTGIVCIATEKHTGKQVAVKKMD--LRKQQRRELLFNEVVIMRDYHHDNVVDMYS 109 Query: 89 AFTPQRNLEEFQDVYLVMELMDANLCQVI--QMDLDHDRMSYLLYQMLCGIKHLHSAGII 146 ++ ++++VME ++ I ++ ++++ + +L + +LH+ G+I Sbjct: 110 SYLV------GDELWVVMEFLEGGALTDIVTHTRMNEEQIATVCLSVLRALSYLHNQGVI 163 Query: 147 HRDLKPSNIVVKADCTLKILDFGL-ARTAGTTFMMTPYVVTRYYRAPEVILGMGYTENVD 205 HRD+K +I++ +D +K+ DFG A+ + V T Y+ APEVI + Y VD Sbjct: 164 HRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVD 223 Query: 206 IWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENRPRYT 265 IWS+G ++ EMI G + + +I + L Sbjct: 224 IWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSL-------------------------- 257 Query: 266 GYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEYINV 322 ++ + +S R L MLV +P QR + E L H ++ + Sbjct: 258 --------------PPRVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKL 300 >3Q53-A nrPDB Length = 306 Score = 246 bits (628), Expect = 1e-65, Method: Composition-based stats. Identities = 78/315 (24%), Positives = 136/315 (43%), Gaps = 55/315 (17%) Query: 11 VEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYR 70 V VGD +Y IG GA G V A D T Q VAI++++ Q + Sbjct: 14 VSVGDPK----KKYTRFEKIGQGASGTVYTAMDVATGQEVAIRQMN--LQQQPKKELIIN 67 Query: 71 EFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQ--VIQMDLDHDRMSY 128 E +M+ + NI+ L+++ ++++VME + V + +D +++ Sbjct: 68 EILVMRENKNPNIVNYLDSYLV------GDELWVVMEYLAGGSLTDVVTETCMDEGQIAA 121 Query: 129 LLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGL-ARTAGTTFMMTPYVVTR 187 + + L ++ LHS +IHRD+K NI++ D ++K+ DFG A+ + V T Sbjct: 122 VCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTP 181 Query: 188 YYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFM 247 Y+ APEV+ Y VDIWS+G + EMI G + + + I GTP Sbjct: 182 YWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATN-GTPELQNP 240 Query: 248 QRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQ 307 ++L ++ R+ L++ L +D E+ Sbjct: 241 EKL---------------------------------------SAIFRDFLNRCLEMDVEK 261 Query: 308 RISVDEALKHEYINV 322 R S E ++H+++ + Sbjct: 262 RGSAKELIQHQFLKI 276 >4FIE-A nrPDB Length = 423 Score = 246 bits (627), Expect = 2e-65, Method: Composition-based stats. Identities = 72/315 (22%), Positives = 134/315 (42%), Gaps = 55/315 (17%) Query: 9 YTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRA 68 V+ GD + N IG G+ GIVC A + + VA+KK+ + + Sbjct: 142 LVVDPGDPRSYLD----NFIKIGEGSTGIVCIATVRSSGKLVAVKKMD--LRKQQRRELL 195 Query: 69 YREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVI--QMDLDHDRM 126 + E +M+ H+N++ + N++ ++++VME ++ I ++ +++ Sbjct: 196 FNEVVIMRDYQHENVVEMYNSYLV------GDELWVVMEFLEGGALTDIVTHTRMNEEQI 249 Query: 127 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGL-ARTAGTTFMMTPYVV 185 + + +L + LH+ G+IHRD+K +I++ D +K+ DFG A+ + V Sbjct: 250 AAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVG 309 Query: 186 TRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPS 245 T Y+ APE+I + Y VDIWS+G ++ EM+ G + + I + L Sbjct: 310 TPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNL------ 363 Query: 246 FMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDP 305 +N + + + L ++LV DP Sbjct: 364 ----------------------------------PPRLKNLHKVSPSLKGFLDRLLVRDP 389 Query: 306 EQRISVDEALKHEYI 320 QR + E LKH ++ Sbjct: 390 AQRATAAELLKHPFL 404 >3ZUT-A nrPDB Length = 362 Score = 246 bits (627), Expect = 2e-65, Method: Composition-based stats. Identities = 77/346 (22%), Positives = 134/346 (38%), Gaps = 52/346 (15%) Query: 21 HSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNH 80 RY ++ IGSG G+ D + + VA+K + R + RE + + H Sbjct: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIER---GEKIDENVKREIINHRSLRH 74 Query: 81 KNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN-LCQVI--QMDLDHDRMSYLLYQMLCGI 137 NI+ +L +VME L + I D + Q++ G+ Sbjct: 75 PNIVRFKEVILTPTHLA------IVMEYASGGELFERICNAGRFSEDEARFFFQQLISGV 128 Query: 138 KHLHSAGIIHRDLKPSNIVVKAD--CTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVI 195 + H+ + HRDLK N ++ LKI FG ++++ V T Y APEV+ Sbjct: 129 SYCHAMQVCHRDLKLENTLLDGSPAPRLKICAFGYSKSSVLHSQPKSTVGTPAYIAPEVL 188 Query: 196 LGMGYTENV-DIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTV 254 L Y V D+WS G + M+ G F + + K I ++ +Q + Sbjct: 189 LKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRI--------LNVQYAI 240 Query: 255 RNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEA 314 +YV + + R+L+S++ V DP +RIS+ E Sbjct: 241 PDYV-----------------------------HISPECRHLISRIFVADPAKRISIPEI 271 Query: 315 LKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYEEVM 360 HE+ A+ ++ D+ ++E+ ++I E + Sbjct: 272 RNHEWFLKNLPADLMNDNTMTTQFDESDQPGQSIEEIMQIIAEATV 317 >3IS5-A nrPDB Length = 285 Score = 245 bits (626), Expect = 2e-65, Method: Composition-based stats. Identities = 80/314 (25%), Positives = 132/314 (42%), Gaps = 58/314 (18%) Query: 19 TIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLV 78 TI +I R +GSGA G V + + IK +++ V ++ E +++K + Sbjct: 19 TIDDLFIFKRKLGSGAFGDVHLVEERSSGLERVIKTINKDRSQVPM-EQIEAEIEVLKSL 77 Query: 79 NHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN-LCQVI------QMDLDHDRMSYLLY 131 +H NII + F E++ ++Y+VME + L + I L ++ L+ Sbjct: 78 DHPNIIKIFEVF------EDYHNMYIVMETCEGGELLERIVSAQARGKALSEGYVAELMK 131 Query: 132 QMLCGIKHLHSAGIIHRDLKPSNIVVKA---DCTLKILDFGLARTAGTTFMMTPYVVTRY 188 QM+ + + HS ++H+DLKP NI+ + +KI+DFGLA + T T Sbjct: 132 QMMNALAYFHSQHVVHKDLKPENILFQDTSPHSPIKIIDFGLAELFKSDEHSTNAAGTAL 191 Query: 189 YRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQ 248 Y APEV T DIWS G +M ++ G + F GT ++ ++ P++ Sbjct: 192 YMAPEVFK-RDVTFKCDIWSAGVVMYFLLTGCLPFTGTS----LEEVQQKATYKEPNYAV 246 Query: 249 RLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQR 308 +P A +LL +ML DPE+R Sbjct: 247 ECRP------------------------------------LTPQAVDLLKQMLTKDPERR 270 Query: 309 ISVDEALKHEYINV 322 S + L HE+ Sbjct: 271 PSAAQVLHHEWFKQ 284 >4D2V-A nrPDB Length = 356 Score = 244 bits (624), Expect = 4e-65, Method: Composition-based stats. Identities = 76/331 (22%), Positives = 130/331 (39%), Gaps = 57/331 (17%) Query: 19 TIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLV 78 + Y IG+G V A +T + VAIK + + + R E + +K + Sbjct: 26 ELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLG-SDLPRIKTEIEALKNL 84 Query: 79 NHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN-LCQVI--QMDLDHDRMSYLLYQMLC 135 H++I L + LE +++V+E L I Q L + + Q++ Sbjct: 85 RHQHICQLYHV------LETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVS 138 Query: 136 GIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTA--GTTFMMTPYVVTRYYRAPE 193 + ++HS G HRDLKP N++ LK++DFGL + + Y APE Sbjct: 139 AVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQACCGALAYAAPE 198 Query: 194 VILGMGY-TENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQP 252 +I G Y D+WS+G ++ ++ G + F KI+ Sbjct: 199 LIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDTAAALVAKIM---------------- 242 Query: 253 TVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVD 312 R +Y + + + LL +ML +DP++RIS+ Sbjct: 243 --------RGKYDVPKW-------------------LSPSSILLLQQMLQVDPKKRISMK 275 Query: 313 EALKHEYINVWYDAEEVDAPAPEPYDHSVDE 343 L H +I Y+ V+ + P+ H D+ Sbjct: 276 NLLNHPWIMQDYN-YPVEWQSKNPFIHLDDD 305 >4JDH-A nrPDB Length = 346 Score = 244 bits (624), Expect = 4e-65, Method: Composition-based stats. Identities = 72/315 (22%), Positives = 134/315 (42%), Gaps = 55/315 (17%) Query: 9 YTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRA 68 V+ GD + N IG G+ GIVC A + + VA+KK+ + + Sbjct: 65 LVVDPGDPRSYLD----NFIKIGEGSTGIVCIATVRSSGKLVAVKKMD--LRKQQRRELL 118 Query: 69 YREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVI--QMDLDHDRM 126 + E +M+ H+N++ + N++ ++++VME ++ I ++ +++ Sbjct: 119 FNEVVIMRDYQHENVVEMYNSYLV------GDELWVVMEFLEGGALTDIVTHTRMNEEQI 172 Query: 127 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGL-ARTAGTTFMMTPYVV 185 + + +L + LH+ G+IHRD+K +I++ D +K+ DFG A+ + V Sbjct: 173 AAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVG 232 Query: 186 TRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPS 245 T Y+ APE+I + Y VDIWS+G ++ EM+ G + + I + L Sbjct: 233 TPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNL------ 286 Query: 246 FMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDP 305 +N + + + L ++LV DP Sbjct: 287 ----------------------------------PPRLKNLHKVSPSLKGFLDRLLVRDP 312 Query: 306 EQRISVDEALKHEYI 320 QR + E LKH ++ Sbjct: 313 AQRATAAELLKHPFL 327 >2Q0N-A nrPDB Length = 301 Score = 244 bits (622), Expect = 5e-65, Method: Composition-based stats. Identities = 72/315 (22%), Positives = 134/315 (42%), Gaps = 55/315 (17%) Query: 9 YTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRA 68 V+ GD + N IG G+ GIVC A + + VA+KK+ + + Sbjct: 20 LVVDPGDPRSYLD----NFIKIGEGSTGIVCIATVRSSGKLVAVKKMD--LRKQQRRELL 73 Query: 69 YREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVI--QMDLDHDRM 126 + E +M+ H+N++ + N++ ++++VME ++ I ++ +++ Sbjct: 74 FNEVVIMRDYQHENVVEMYNSYLV------GDELWVVMEFLEGGALTDIVTHTRMNEEQI 127 Query: 127 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGL-ARTAGTTFMMTPYVV 185 + + +L + LH+ G+IHRD+K +I++ D +K+ DFG A+ + V Sbjct: 128 AAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVG 187 Query: 186 TRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPS 245 T Y+ APE+I + Y VDIWS+G ++ EM+ G + + I + L Sbjct: 188 TPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNL------ 241 Query: 246 FMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDP 305 +N + + + L ++LV DP Sbjct: 242 ----------------------------------PPRLKNLHKVSPSLKGFLDRLLVRDP 267 Query: 306 EQRISVDEALKHEYI 320 QR + E LKH ++ Sbjct: 268 AQRATAAELLKHPFL 282 >4XBR-A nrPDB Length = 366 Score = 243 bits (621), Expect = 7e-65, Method: Composition-based stats. Identities = 72/315 (22%), Positives = 134/315 (42%), Gaps = 55/315 (17%) Query: 9 YTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRA 68 V+ GD + N IG G+ GIVC A + + VA+KK+ + + Sbjct: 85 LVVDPGDPRSYLD----NFIKIGEGSTGIVCIATVRSSGKLVAVKKMD--LRKQQRRELL 138 Query: 69 YREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVI--QMDLDHDRM 126 + E +M+ H+N++ + N++ ++++VME ++ I ++ +++ Sbjct: 139 FNEVVIMRDYQHENVVEMYNSYLV------GDELWVVMEFLEGGALTDIVTHTRMNEEQI 192 Query: 127 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGL-ARTAGTTFMMTPYVV 185 + + +L + LH+ G+IHRD+K +I++ D +K+ DFG A+ + V Sbjct: 193 AAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVG 252 Query: 186 TRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPS 245 T Y+ APE+I + Y VDIWS+G ++ EM+ G + + I + L Sbjct: 253 TPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNL------ 306 Query: 246 FMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDP 305 +N + + + L ++LV DP Sbjct: 307 ----------------------------------PPRLKNLHKVSPSLKGFLDRLLVRDP 332 Query: 306 EQRISVDEALKHEYI 320 QR + E LKH ++ Sbjct: 333 AQRATAAELLKHPFL 347 >3UDB-A nrPDB Length = 317 Score = 243 bits (621), Expect = 7e-65, Method: Composition-based stats. Identities = 77/346 (22%), Positives = 133/346 (38%), Gaps = 52/346 (15%) Query: 21 HSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNH 80 RY ++ IG+G G+ D + VA+K + R + RE + + H Sbjct: 18 SDRYELVKDIGAGNFGVARLMRDKQANELVAVKYIER---GEKIDENVKREIINHRSLRH 74 Query: 81 KNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN-LCQVI--QMDLDHDRMSYLLYQMLCGI 137 NI+ +L +VME L + I D + Q++ G+ Sbjct: 75 PNIVRFKEVILTPTHLA------IVMEYASGGELFERICNAGRFSEDEARFFFQQLISGV 128 Query: 138 KHLHSAGIIHRDLKPSNIVVKAD--CTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVI 195 + H+ + HRDLK N ++ LKI DFG ++ + V T Y APEV+ Sbjct: 129 SYAHAMQVAHRDLKLENTLLDGSPAPRLKIADFGYSKASVLHSQPKSAVGTPAYIAPEVL 188 Query: 196 LGMGYTENV-DIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTV 254 L Y V D+WS G + M+ G F + + K I ++ +Q + Sbjct: 189 LKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRI--------LNVQYAI 240 Query: 255 RNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEA 314 +YV + + R+L+S++ V DP +RIS+ E Sbjct: 241 PDYV-----------------------------HISPECRHLISRIFVADPAKRISIPEI 271 Query: 315 LKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYEEVM 360 HE+ A+ ++ D+ ++E+ ++I E + Sbjct: 272 RNHEWFLKNLPADLMNDNTMTTQFDESDQPGQSIEEIMQIIAEATV 317 >2YAB-A nrPDB Length = 361 Score = 243 bits (621), Expect = 8e-65, Method: Composition-based stats. Identities = 71/313 (22%), Positives = 121/313 (38%), Gaps = 56/313 (17%) Query: 20 IHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHA----KRAYREFKLM 75 + Y +GSG IV + T A K + + + + RE ++ Sbjct: 10 VEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIEREVSIL 69 Query: 76 KLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN-LCQVI--QMDLDHDRMSYLLYQ 132 + V H NII L + + E DV L++EL+ L + + L + + + Q Sbjct: 70 RQVLHPNIITLHDVY------ENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQ 123 Query: 133 MLCGIKHLHSAGIIHRDLKPSNIVVKADC----TLKILDFGLARTAGTTFMMTPYVVTRY 188 +L G+ +LH+ I H DLKP NI++ +K++DFGLA T Sbjct: 124 ILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPE 183 Query: 189 YRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQ 248 + APE++ D+WS+G I ++ G F G + I Sbjct: 184 FVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAV---------- 233 Query: 249 RLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQR 308 Y FD F + + A++ + K+LV + +R Sbjct: 234 -----------------SYDFDEEF------------FSQTSELAKDFIRKLLVKETRKR 264 Query: 309 ISVDEALKHEYIN 321 +++ EAL+H +I Sbjct: 265 LTIQEALRHPWIT 277 >2UV2-A nrPDB Length = 325 Score = 243 bits (620), Expect = 1e-64, Method: Composition-based stats. Identities = 78/362 (21%), Positives = 141/362 (38%), Gaps = 68/362 (18%) Query: 2 TTAQHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQN 61 + Q++H T ++ +F + + +G GA G V A + T A K + ++ Sbjct: 22 SMKQYEHVTRDLNPEDF-----WEIIGELGDGAFGKVYKAQNKETSVLAAAKVID--TKS 74 Query: 62 VTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQ----VI 117 + E ++ +H NI+ LL+AF + NL ++++E + Sbjct: 75 EEELEDYMVEIDILASCDHPNIVKLLDAFYYENNL------WILIEFCAGGAVDAVMLEL 128 Query: 118 QMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGL-ARTAGT 176 + L ++ + Q L + +LH IIHRDLK NI+ D +K+ DFG+ A+ T Sbjct: 129 ERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRT 188 Query: 177 TFMMTPYVVTRYYRAPEVIL-----GMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQ 231 ++ T Y+ APEV++ Y D+WS+G + EM + + Sbjct: 189 IQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRV 248 Query: 232 WNKIIEQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKAS 291 KI + + P+ Q R +S Sbjct: 249 LLKIAK---SEPPTLAQ-------------------------------------PSRWSS 268 Query: 292 DARNLLSKMLVIDPEQRISVDEALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQW 351 + ++ L K L + + R + + L+H ++ V + + P E + E VE Sbjct: 269 NFKDFLKKCLEKNVDARWTTSQLLQHPFVTV-----DSNKPIRELIAEAKAEVTEEVEDG 323 Query: 352 KE 353 KE Sbjct: 324 KE 325 >4CQG-A nrPDB Length = 331 Score = 243 bits (620), Expect = 1e-64, Method: Composition-based stats. Identities = 73/331 (22%), Positives = 130/331 (39%), Gaps = 57/331 (17%) Query: 19 TIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLV 78 + Y IG+G V A +T + VAIK + + + R E +K + Sbjct: 6 ELLKYYELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALG-SDLPRVKTEIDALKSL 64 Query: 79 NHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN-LCQVI--QMDLDHDRMSYLLYQMLC 135 H++I L + LE +++V+E L I Q L + + Q+L Sbjct: 65 RHQHICQLYHV------LETKNKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQILS 118 Query: 136 GIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTA--GTTFMMTPYVVTRYYRAPE 193 + ++HS G HRDLKP N++ + LK++DFGL + + + Y APE Sbjct: 119 AVAYVHSQGYAHRDLKPENLLFDENHKLKLIDFGLCAKPKGNKDYHLQECCGSLAYAAPE 178 Query: 194 VILGMGY-TENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQP 252 +I G Y D+WS+G ++ ++ G + F + + + KI+ Sbjct: 179 LIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRG-------------- 224 Query: 253 TVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVD 312 + + + + LL +ML +DP++RIS+ Sbjct: 225 -----------------------------KYEVPKWLSPSSILLLQQMLQVDPKKRISMR 255 Query: 313 EALKHEYINVWYDAEEVDAPAPEPYDHSVDE 343 L H ++ Y V+ + P H ++ Sbjct: 256 NLLNHPWVMQDYSC-PVEWQSKTPLTHLDED 285 >3UC3-A nrPDB Length = 361 Score = 242 bits (619), Expect = 1e-64, Method: Composition-based stats. Identities = 75/343 (21%), Positives = 130/343 (37%), Gaps = 52/343 (15%) Query: 21 HSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNH 80 RY ++ IGSG G+ D +T++ VA+K + R + RE + + H Sbjct: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIER---GAAIDENVQREIINHRSLRH 75 Query: 81 KNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN-LCQVI--QMDLDHDRMSYLLYQMLCGI 137 NI+ +L ++ME L + I D + Q+L G+ Sbjct: 76 PNIVRFKEVILTPTHLA------IIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGV 129 Query: 138 KHLHSAGIIHRDLKPSNIVVKAD--CTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVI 195 + HS I HRDLK N ++ LKI DFG ++++ V T Y APEV+ Sbjct: 130 SYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVL 189 Query: 196 LGMGYTEN-VDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTV 254 L Y D+WS G + M+ G F + + K I+++ + S + Sbjct: 190 LRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDI---- 245 Query: 255 RNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEA 314 R + + +L+S++ V DP RIS+ E Sbjct: 246 ---------------------------------RISPECCHLISRIFVADPATRISIPEI 272 Query: 315 LKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYE 357 H + A+ ++ ++ +++ ++I E Sbjct: 273 KTHSWFLKNLPADLMNESNTGSQFQEPEQPMQSLDTIMQIISE 315 >4UZD-A nrPDB Length = 287 Score = 242 bits (619), Expect = 1e-64, Method: Composition-based stats. Identities = 73/304 (24%), Positives = 126/304 (41%), Gaps = 54/304 (17%) Query: 22 SRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRP-FQNVTHAKRAYREFKLMKLVNH 80 + RP+G G G V A + ++ +A+K L + + + RE ++ + H Sbjct: 8 EDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRH 67 Query: 81 KNIIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQM--DLDHDRMSYLLYQMLCGI 137 NI+ L F + VYL++E + + +Q D R + + ++ + Sbjct: 68 PNILRLYGYF------HDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANAL 121 Query: 138 KHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILG 197 + HS +IHRD+KP N+++ + LKI DFG + A ++ T T Y PE+I G Sbjct: 122 SYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSS-RRTTLCGTLDYLPPEMIEG 180 Query: 198 MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNY 257 + E VD+WS+G + E + G F + + + +I T Sbjct: 181 RMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFT---------------- 224 Query: 258 VENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKH 317 FPD AR+L+S++L +P QR + E L+H Sbjct: 225 ---------------FPDF------------VTEGARDLISRLLKHNPSQRPMLREVLEH 257 Query: 318 EYIN 321 +I Sbjct: 258 PWIT 261 >3D2K-A nrPDB Length = 272 Score = 242 bits (619), Expect = 1e-64, Method: Composition-based stats. Identities = 73/313 (23%), Positives = 130/313 (41%), Gaps = 54/313 (17%) Query: 13 VGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRP-FQNVTHAKRAYRE 71 +G + RP+G G G V A + ++ +A+K L + + + RE Sbjct: 3 LGSKRQWTLEDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVEHQLRRE 62 Query: 72 FKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQM--DLDHDRMSY 128 ++ + H NI+ L F + VYL++E + + +Q D R + Sbjct: 63 VEIQSHLRHPNILRLYGYF------HDATRVYLILEYAPLGTVYRELQKLSRFDEQRTAT 116 Query: 129 LLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRY 188 + ++ + + HS +IHRD+KP N+++ ++ LKI DFG + A ++ T T Sbjct: 117 YITELANALSYCHSKRVIHRDIKPENLLLGSNGELKIADFGWSVHAPSS-RRTTLCGTLD 175 Query: 189 YRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQ 248 Y PE+I G + E VD+WS+G + E + G F + + + +I T Sbjct: 176 YLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGMPPFEAHTYQETYRRISRVEFT------- 228 Query: 249 RLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQR 308 FPD AR+L+S++L + QR Sbjct: 229 ------------------------FPDF------------VTEGARDLISRLLKHNASQR 252 Query: 309 ISVDEALKHEYIN 321 +++ E L+H +I Sbjct: 253 LTLAEVLEHPWIK 265 >2JD5-A nrPDB Length = 373 Score = 242 bits (617), Expect = 3e-64, Method: Composition-based stats. Identities = 100/373 (26%), Positives = 166/373 (44%), Gaps = 45/373 (12%) Query: 21 HSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNH 80 +RYI +R +G G V A D + +VA+K + + + + A E KL++ VN Sbjct: 18 DARYILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVR---GDKVYTEAAEDEIKLLQRVND 74 Query: 81 K-----------NIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQM----DLDHDR 125 +I+ LL+ F + V +V E++ NL +I+ + Sbjct: 75 ADNTKEDSMGANHILKLLDHFNHKGP--NGVHVVMVFEVLGENLLALIKKYEHRGIPLIY 132 Query: 126 MSYLLYQMLCGIKHLHSA-GIIHRDLKPSNIVVK------ADCTLKILDFGLARTAGTTF 178 + + Q+L G+ ++H GIIH D+KP N++++ +KI D G A + Sbjct: 133 VKQISKQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNACWYDEHY 192 Query: 179 MMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTD------HIDQW 232 T + TR YR+PEV+LG + DIWS C++ E+I G LF + D Sbjct: 193 --TNSIQTREYRSPEVLLGAPWGCGADIWSTACLIFELITGDFLFEPDEGHSYTKDDDHI 250 Query: 233 NKIIEQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASD 292 +IIE LG PS++ R R + +R S + +P + + S+ +A + Sbjct: 251 AQIIELLGE-LPSYLLRNGKYTRTFFNSRGLLRNISKLKFWPLEDVLTEKYKFSKDEAKE 309 Query: 293 ARNLLSKMLVIDPEQRISVDEALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWK 352 + LS ML +DP +R + H ++ EE+ P E Y D + W Sbjct: 310 ISDFLSPMLQLDPRKRADAGGLVNHPWLKDTLGMEEIRVPDRELYGSGSD-----IPGW- 363 Query: 353 ELIYEEVMDYEAH 365 +EEV D++ H Sbjct: 364 ---FEEVRDHKRH 373 >3GUB-A nrPDB Length = 295 Score = 241 bits (616), Expect = 3e-64, Method: Composition-based stats. Identities = 68/313 (21%), Positives = 122/313 (38%), Gaps = 56/313 (17%) Query: 20 IHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHA----KRAYREFKLM 75 + Y +GSG +V + T A K + + + + RE ++ Sbjct: 9 VDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSIL 68 Query: 76 KLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN-LCQVI--QMDLDHDRMSYLLYQ 132 K + H N+I L + E DV L+ EL+ L + + L + + L Q Sbjct: 69 KEIQHPNVITLHEVY------ENKTDVILIGELVAGGELFDFLAEKESLTEEEATEFLKQ 122 Query: 133 MLCGIKHLHSAGIIHRDLKPSNIVVKADCT----LKILDFGLARTAGTTFMMTPYVVTRY 188 +L G+ +LHS I H DLKP NI++ +KI+DFGLA T Sbjct: 123 ILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPE 182 Query: 189 YRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQ 248 + APE++ D+WS+G I ++ G F G + + Sbjct: 183 FVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANV------------- 229 Query: 249 RLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQR 308 Y F+ ++ ++ A++ + ++LV DP++R Sbjct: 230 --------------SAVNYEFE------------DEYFSNTSALAKDFIRRLLVKDPKKR 263 Query: 309 ISVDEALKHEYIN 321 +++ ++L+H +I Sbjct: 264 MTIQDSLQHPWIK 276 >5JZN-A nrPDB Length = 280 Score = 241 bits (615), Expect = 4e-64, Method: Composition-based stats. Identities = 84/324 (25%), Positives = 132/324 (40%), Gaps = 61/324 (18%) Query: 12 EVGDTNF----TIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKR 67 EV + F TI RY R IG G +V + T + A+K + + Sbjct: 5 EVSEEGFQIPATITERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEH-M 63 Query: 68 AYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELM-DANLCQVIQM--DLDHD 124 E +++ V H NI+ L+ ++ ++YLVMEL+ +L I Sbjct: 64 IQNEVSILRRVKHPNIVLLIE------EMDVPTELYLVMELVKGGDLFDAITSTNKYTER 117 Query: 125 RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVV----KADCTLKILDFGLARTAGTTFMM 180 S +LY + IK+LHS I+HRD+KP N++V +LK+ DFGLA + Sbjct: 118 DASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIV--DGPL 175 Query: 181 TPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLF--PGTDHIDQWNKIIEQ 238 T Y APE+I GY VDIW+ G I ++ G F G D +++I+ Sbjct: 176 YTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQIL-- 233 Query: 239 LGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLS 298 F + D + A+ L++ Sbjct: 234 -------------------------MGQVDFPSPYWD------------NVSDSAKELIT 256 Query: 299 KMLVIDPEQRISVDEALKHEYINV 322 ML++D +QR S + L+H ++N Sbjct: 257 MMLLVDVDQRFSAVQVLEHPWVND 280 >6FDY-U nrPDB Length = 276 Score = 241 bits (614), Expect = 5e-64, Method: Composition-based stats. Identities = 73/309 (23%), Positives = 121/309 (39%), Gaps = 52/309 (16%) Query: 24 YINLRPIGSGAQGIVCAAY-DTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKN 82 +I +GSG V AY T++ VAIK +++ N + E +++K + H + Sbjct: 13 FILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKGIRHPH 72 Query: 83 IIGLLNAFTPQRNLEEFQDVYLVMELM-DANLCQVIQMD--LDHDRMSYLLYQMLCGIKH 139 I+ L + N +YL+ME +L + I L + Q+ ++ Sbjct: 73 IVQLKDFQWDSDN------IYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQF 126 Query: 140 LHSAGIIHRDLKPSNIVVK--ADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILG 197 LH I H DLKP NI++ LK+ DFG A+ + Y APE++ Sbjct: 127 LHERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMVCQ 186 Query: 198 MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNY 257 Y VD+WS+G I+ E + G F + KI P L+P + Sbjct: 187 RQYDARVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELP-----LRPLL--- 238 Query: 258 VENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKH 317 + D R+LL ++L DP +RIS + H Sbjct: 239 --------------------------------SRDCRDLLQRLLERDPSRRISFQDFFAH 266 Query: 318 EYINVWYDA 326 ++++ + Sbjct: 267 PWVDLEHMP 275 >5YKS-A nrPDB Length = 377 Score = 240 bits (613), Expect = 7e-64, Method: Composition-based stats. Identities = 71/344 (20%), Positives = 128/344 (37%), Gaps = 56/344 (16%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNI 83 Y + +G G +V A T + VA+K + + + ++E + MKLV H NI Sbjct: 37 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHPNI 96 Query: 84 IGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVI---QMDLDHDRMSYLLYQMLCGIKH 139 + L Q +YL++EL D ++ I + L+ D Q++ I + Sbjct: 97 VRLYEVIDTQ------TKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISY 150 Query: 140 LHSAGIIHRDLKPSN-IVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGM 198 H ++HRDLKP N + + +K+ DFG + +T + Y APE++LG Sbjct: 151 CHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGD 210 Query: 199 GYT-ENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNY 257 Y VDIWS+G I+ ++ G F + + I++ T + + + Sbjct: 211 EYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLIT-- 268 Query: 258 VENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKH 317 +ML DP++R S++E H Sbjct: 269 -----------------------------------------RMLQRDPKRRASLEEIENH 287 Query: 318 EYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYEEVMD 361 ++ D + E + ++ ++ D Sbjct: 288 PWLQ-GVDPSPATKYNIPLVSYKNLSEEEHNSIIQRMVLGDIAD 330 >5D9K-A nrPDB Length = 330 Score = 240 bits (612), Expect = 9e-64, Method: Composition-based stats. Identities = 74/314 (23%), Positives = 132/314 (42%), Gaps = 63/314 (20%) Query: 21 HSRYINLRPIGSGAQGIVCAAYDT---ITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKL 77 S++ L+ +G G+ G V +Q A+K L + V R E ++ Sbjct: 29 PSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVE 88 Query: 78 VNHKNIIGLLNAFTPQRNLEEFQDVYLVMELM-DANLCQVIQMD--LDHDRMSYLLYQML 134 VNH I+ L AF + L YL+++ + +L + + + + + L ++ Sbjct: 89 VNHPFIVKLHYAFQTEGKL------YLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELA 142 Query: 135 CGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMM-TPYVVTRYYRAPE 193 + HLHS GII+RDLKP NI++ + +K+ DFGL++ + + T Y APE Sbjct: 143 LALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPE 202 Query: 194 VILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIE-QLGTPSPSFMQRLQP 252 V+ G+T++ D WS G +M EM+ G + F G D + I++ +LG P Sbjct: 203 VVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMP---------- 252 Query: 253 TVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISV- 311 + + +A++LL + +P R+ Sbjct: 253 ----------------------------------QFLSPEAQSLLRMLFKRNPANRLGAG 278 Query: 312 ----DEALKHEYIN 321 +E +H + + Sbjct: 279 PDGVEEIKRHSFFS 292 >6O6Q-A nrPDB Length = 335 Score = 239 bits (611), Expect = 1e-63, Method: Composition-based stats. Identities = 73/326 (22%), Positives = 150/326 (46%), Gaps = 22/326 (6%) Query: 1 MTTAQHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQ 60 ++T ++ + + + Y LR +G G V D ++ V IK L Sbjct: 20 LSTKPQSYWDYDDLNIKWNPQENYEILRKLGRGKYSEVFLGIDLEKREKVVIKVLK---- 75 Query: 61 NVTHAKRAYREFKLMKLV-NHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQM 119 K+ RE ++K + + NII +L+ ++ + L+ E ++ + + Sbjct: 76 -PVKRKKIKREISILKNLVDGPNIIAMLDVVREPQS----KTPGLIFEHINNIDFRSLYP 130 Query: 120 DLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCT-LKILDFGLARTAGTTF 178 + + +Y++L + + HS GI+HRD+KP N+++ D L+++D+GLA Sbjct: 131 TFTDYDIRFYMYELLKALDYSHSMGIMHRDVKPHNVMIDHDKKLLRLIDWGLAEYYHPGT 190 Query: 179 MMTPYVVTRYYRAPEVILGMG-YTENVDIWSVGCIMGEM-IRGGVLFPGTDHIDQWNKII 236 V +RY++ PE+++ Y ++D+WS GC++ M F G + DQ +I+ Sbjct: 191 EYNVRVASRYFKGPELLVDYRLYDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQLVQIV 250 Query: 237 EQLGTPS-PSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARN 295 LG+ + ++++ ++ E+ Y + R N N + + + Sbjct: 251 RVLGSKNFKKYLEKYNISLGEEYEDIGYYNKRQWVRFM--------NENNKDLVSQEFLD 302 Query: 296 LLSKMLVIDPEQRISVDEALKHEYIN 321 L+ ++L D ++R++ EA+KH Y + Sbjct: 303 LIDRLLRYDHQERLTAKEAMKHAYFD 328 >3UTO-A nrPDB Length = 573 Score = 239 bits (609), Expect = 2e-63, Method: Composition-based stats. Identities = 69/353 (19%), Positives = 128/353 (36%), Gaps = 53/353 (15%) Query: 7 QHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAK 66 Q+Y V + + Y +G+GA G+V + T N A K + P ++ + Sbjct: 142 QYYPQPVEIKHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHES--DKE 199 Query: 67 RAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN-LCQVI---QMDLD 122 +E + M ++ H ++ L +AF ++ ++ E M L + + + Sbjct: 200 TVRKEIQTMSVLRHPTLVNLHDAFEDDN------EMVMIYEFMSGGELFEKVADEHNKMS 253 Query: 123 HDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK--ADCTLKILDFGLARTAGTTFMM 180 D + Q+ G+ H+H +H DLKP NI+ LK++DFGL + Sbjct: 254 EDEAVEYMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSV 313 Query: 181 TPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLG 240 T + APEV G D+WSVG + ++ G F G + + + Sbjct: 314 KVTTGTAEFAAPEVAEGKPVGYYTDMWSVGVLSYILLSGLSPFGGENDDETLRNV----- 368 Query: 241 TPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKM 300 N ++ + D ++ + K+ Sbjct: 369 ----------------------------------KSCDWNMDDSAFSGISEDGKDFIRKL 394 Query: 301 LVIDPEQRISVDEALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKE 353 L+ DP R+++ +AL+H ++ Y D + + W E Sbjct: 395 LLADPNTRMTIHQALEHPWLTPGNAPGRDSQIPSSRYTKIRDSIKTKYDAWPE 447 >2A27-A nrPDB Length = 321 Score = 238 bits (608), Expect = 2e-63, Method: Composition-based stats. Identities = 70/313 (22%), Positives = 121/313 (38%), Gaps = 56/313 (17%) Query: 20 IHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHA----KRAYREFKLM 75 + Y +GSG IV + T A K + + + + RE ++ Sbjct: 10 VEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSIL 69 Query: 76 KLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN-LCQVI--QMDLDHDRMSYLLYQ 132 + V H N+I L + + E DV L++EL+ L + + L + + + Q Sbjct: 70 RQVLHHNVITLHDVY------ENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQ 123 Query: 133 MLCGIKHLHSAGIIHRDLKPSNIVVKADC----TLKILDFGLARTAGTTFMMTPYVVTRY 188 +L G+ +LH+ I H DLKP NI++ +K++DFGLA T Sbjct: 124 ILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPE 183 Query: 189 YRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQ 248 + APE++ D+WS+G I ++ G F G + I Sbjct: 184 FVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAV---------- 233 Query: 249 RLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQR 308 Y FD F + + A++ + K+LV + +R Sbjct: 234 -----------------SYDFDEEF------------FSQTSELAKDFIRKLLVKETRKR 264 Query: 309 ISVDEALKHEYIN 321 +++ EAL+H +I Sbjct: 265 LTIQEALRHPWIT 277 >2Y7J-A nrPDB Length = 365 Score = 237 bits (606), Expect = 4e-63, Method: Composition-based stats. Identities = 69/319 (21%), Positives = 126/319 (39%), Gaps = 61/319 (19%) Query: 19 TIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLS------RPFQNVTHAKRAYREF 72 + +Y IG G +V T A+K + P Q + RE Sbjct: 91 EFYQKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRET 150 Query: 73 KLMKLV-NHKNIIGLLNAFTPQRNLEEFQDVYLVMELM-DANLCQVI--QMDLDHDRMSY 128 +++ V H +II L++++ + +LV +LM L + ++ L Sbjct: 151 HILRQVAGHPHIITLIDSYESSSFM------FLVFDLMRKGELFDYLTEKVALSEKETRS 204 Query: 129 LLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRY 188 ++ +L + LH+ I+HRDLKP NI++ + +++ DFG + + T Sbjct: 205 IMRSLLEAVSFLHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEPGEKLRELCGTPG 264 Query: 189 YRAPEVILGM------GYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTP 242 Y APE++ GY + VD+W+ G I+ ++ G F I I+E Sbjct: 265 YLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIME----- 319 Query: 243 SPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLV 302 Y F D ++S ++L+S++L Sbjct: 320 ----------------------GQYQFSSPEWD------------DRSSTVKDLISRLLQ 345 Query: 303 IDPEQRISVDEALKHEYIN 321 +DPE R++ ++AL+H + Sbjct: 346 VDPEARLTAEQALQHPFFE 364 >5KCV-A nrPDB Length = 460 Score = 237 bits (606), Expect = 4e-63, Method: Composition-based stats. Identities = 73/324 (22%), Positives = 120/324 (37%), Gaps = 62/324 (19%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRP-FQNVTHAKRAYREFKLMKLVNHKN 82 + L+ +G G G V + T + A+K L + E ++++ H Sbjct: 164 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF 223 Query: 83 IIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVI---QMDLDHDRMSYLLYQMLCGIKH 139 + L +F L VME + + DR + +++ + + Sbjct: 224 LTALKYSFQTHDRL------CFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDY 277 Query: 140 LHS-AGIIHRDLKPSNIVVKADCTLKILDFGLART-AGTTFMMTPYVVTRYYRAPEVILG 197 LHS +++RDLK N+++ D +KI DFGL + M + T Y APEV+ Sbjct: 278 LHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLED 337 Query: 198 MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNY 257 Y VD W +G +M EM+ G + F DH K+ E + F + L P Sbjct: 338 NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDH----EKLFELILMEEIRFPRTLGP----- 388 Query: 258 VENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRI-----SVD 312 +A++LLS +L DP+QR+ Sbjct: 389 ----------------------------------EAKSLLSGLLKKDPKQRLGGGSEDAK 414 Query: 313 EALKHEYIN--VWYDAEEVDAPAP 334 E ++H + VW E P Sbjct: 415 EIMQHRFFAGIVWQHVYEKKLSPP 438 >2Z7Q-A nrPDB Length = 321 Score = 237 bits (606), Expect = 5e-63, Method: Composition-based stats. Identities = 78/352 (22%), Positives = 143/352 (40%), Gaps = 64/352 (18%) Query: 9 YTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDT---ITQQNVAIKKLSRPFQNVTHA 65 + V+ G S + L+ +G G+ G V + A+K L + V Sbjct: 16 HHVKAGSEKAD-PSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDR 74 Query: 66 KRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELM-DANLCQVIQMD--LD 122 R E ++ VNH ++ L AF + L YL+++ + +L + + Sbjct: 75 VRTKMERDILADVNHPFVVKLHYAFQTEGKL------YLILDFLRGGDLFTRLSKEVMFT 128 Query: 123 HDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMM-T 181 + + + L ++ G+ HLHS GII+RDLKP NI++ + +K+ DFGL++ A Sbjct: 129 EEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAY 188 Query: 182 PYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIE-QLG 240 + T Y APEV+ G++ + D WS G +M EM+ G + F G D + I++ +LG Sbjct: 189 SFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLG 248 Query: 241 TPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKM 300 P + +++A++LL + Sbjct: 249 MP--------------------------------------------QFLSTEAQSLLRAL 264 Query: 301 LVIDPEQRI-----SVDEALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHT 347 +P R+ +E +H + + + P+ +V + + T Sbjct: 265 FKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDT 316 >4L42-A nrPDB Length = 346 Score = 237 bits (605), Expect = 5e-63, Method: Composition-based stats. Identities = 76/336 (22%), Positives = 127/336 (37%), Gaps = 63/336 (18%) Query: 24 YINLRPIGSGAQGIVCAAYDTI---TQQNVAIKKLSRPF--QNVTHAKRAYREFKLMKLV 78 + LR +G G G V T + A+K L + +N E +++ V Sbjct: 20 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEV 79 Query: 79 NHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN-LCQVIQMD--LDHDRMSYLLYQMLC 135 H I+ L+ AF L YL++E + L ++ + D + L ++ Sbjct: 80 KHPFIVDLIYAFQTGGKL------YLILEYLSGGELFMQLEREGIFMEDTACFYLAEISM 133 Query: 136 GIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMT-PYVVTRYYRAPEV 194 + HLH GII+RDLKP NI++ +K+ DFGL + + +T + T Y APE+ Sbjct: 134 ALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEI 193 Query: 195 ILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTV 254 ++ G+ VD WS+G +M +M+ G F G + +KI++ P Q Sbjct: 194 LMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQ------ 247 Query: 255 RNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRI----- 309 +AR+LL K+L + R+ Sbjct: 248 -------------------------------------EARDLLKKLLKRNAASRLGAGPG 270 Query: 310 SVDEALKHEYINVWYDAEEVDAPAPEPYDHSVDERE 345 E H + E + P+ + E Sbjct: 271 DAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEE 306 >1ZWS-A nrPDB Length = 288 Score = 237 bits (605), Expect = 6e-63, Method: Composition-based stats. Identities = 70/313 (22%), Positives = 120/313 (38%), Gaps = 56/313 (17%) Query: 20 IHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHA----KRAYREFKLM 75 + Y +GSG IV + T A K + + + + RE ++ Sbjct: 10 VEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSIL 69 Query: 76 KLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN-LCQVI--QMDLDHDRMSYLLYQ 132 + V H N+I L + + E DV L++EL+ L + + L + + + Q Sbjct: 70 RQVLHHNVITLHDVY------ENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQ 123 Query: 133 MLCGIKHLHSAGIIHRDLKPSNIVVKADC----TLKILDFGLARTAGTTFMMTPYVVTRY 188 +L G+ +LH+ I H DLKP NI++ +K++DFGLA T Sbjct: 124 ILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPE 183 Query: 189 YRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQ 248 + APE++ D+WS+G I ++ G F G + I Sbjct: 184 FVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITSV---------- 233 Query: 249 RLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQR 308 Y FD F + A++ + K+LV + +R Sbjct: 234 -----------------SYDFDEEF------------FSHTSELAKDFIRKLLVKETRKR 264 Query: 309 ISVDEALKHEYIN 321 +++ EAL+H +I Sbjct: 265 LTIQEALRHPWIT 277 >3MV5-A nrPDB Length = 342 Score = 237 bits (605), Expect = 6e-63, Method: Composition-based stats. Identities = 75/333 (22%), Positives = 124/333 (37%), Gaps = 63/333 (18%) Query: 15 DTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRP-FQNVTHAKRAYREFK 73 D T++ + L+ +G G G V + T + A+K L + E + Sbjct: 4 DPRVTMNE-FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENR 62 Query: 74 LMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVI---QMDLDHDRMSYLL 130 +++ H + L +F L VME + + DR + Sbjct: 63 VLQNSRHPFLTALKYSFQTHDRL------CFVMEYANGGELFFHLSRERVFSEDRARFYG 116 Query: 131 YQMLCGIKHLHS-AGIIHRDLKPSNIVVKADCTLKILDFGLART-AGTTFMMTPYVVTRY 188 +++ + +LHS +++RDLK N+++ D +KI DFGL + M + T Sbjct: 117 AEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPE 176 Query: 189 YRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQ 248 Y APEV+ Y VD W +G +M EM+ G + F DH K+ E + F + Sbjct: 177 YLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDH----EKLFELILMEEIRFPR 232 Query: 249 RLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQR 308 L P +A++LLS +L DP+QR Sbjct: 233 TLGP---------------------------------------EAKSLLSGLLKKDPKQR 253 Query: 309 I-----SVDEALKHEYIN--VWYDAEEVDAPAP 334 + E ++H + VW E P Sbjct: 254 LGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPP 286 >1KOA-A nrPDB Length = 491 Score = 236 bits (602), Expect = 1e-62, Method: Composition-based stats. Identities = 69/353 (19%), Positives = 128/353 (36%), Gaps = 53/353 (15%) Query: 7 QHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAK 66 Q+Y V + + Y +G+GA G+V + T N A K + P ++ + Sbjct: 36 QYYPQPVEIKHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHES--DKE 93 Query: 67 RAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN-LCQVI---QMDLD 122 +E + M ++ H ++ L +AF ++ ++ E M L + + + Sbjct: 94 TVRKEIQTMSVLRHPTLVNLHDAFEDDN------EMVMIYEFMSGGELFEKVADEHNKMS 147 Query: 123 HDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK--ADCTLKILDFGLARTAGTTFMM 180 D + Q+ G+ H+H +H DLKP NI+ LK++DFGL + Sbjct: 148 EDEAVEYMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSV 207 Query: 181 TPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLG 240 T + APEV G D+WSVG + ++ G F G + + + Sbjct: 208 KVTTGTAEFAAPEVAEGKPVGYYTDMWSVGVLSYILLSGLSPFGGENDDETLRNV----- 262 Query: 241 TPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKM 300 N ++ + D ++ + K+ Sbjct: 263 ----------------------------------KSCDWNMDDSAFSGISEDGKDFIRKL 288 Query: 301 LVIDPEQRISVDEALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKE 353 L+ DP R+++ +AL+H ++ Y D + + W E Sbjct: 289 LLADPNTRMTIHQALEHPWLTPGNAPGRDSQIPSSRYTKIRDSIKTKYDAWPE 341 >4I6B-A nrPDB Length = 308 Score = 236 bits (602), Expect = 1e-62, Method: Composition-based stats. Identities = 71/318 (22%), Positives = 129/318 (40%), Gaps = 54/318 (16%) Query: 19 TIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTH-AKRAYREFKLMKL 77 T RY + +G G D + A K + + H ++ +E +L ++ Sbjct: 25 TTGKRYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKIDKEIELHRI 84 Query: 78 VNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVI---QMDLDHDRMSYLLYQML 134 ++HK+++ + F + N +Y+++E I + L + Y L Q++ Sbjct: 85 LHHKHVVQFYHYFEDKEN------IYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIV 138 Query: 135 CGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLA-RTAGTTFMMTPYVVTRYYRAPE 193 G+K+LH I+HRDLK N + LK+ DFGLA R T Y +PE Sbjct: 139 SGLKYLHEQEILHRDLKLGNFFINESMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPE 198 Query: 194 VILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPT 253 V+ G+ DIW++GC+M M+ G F T+ + + I E T S + Sbjct: 199 VLNKQGHGAESDIWALGCVMYTMLLGRPPFETTNLKETYRSIREARYTMPSSLL------ 252 Query: 254 VRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDE 313 + A++L++ ML +PE R S+D+ Sbjct: 253 -------------------------------------APAKHLIASMLSKNPEDRPSLDD 275 Query: 314 ALKHEYINVWYDAEEVDA 331 ++H++ + + + + Sbjct: 276 IIRHDFFTQGFTPDRLSS 293 >2X4F-A nrPDB Length = 373 Score = 236 bits (601), Expect = 2e-62, Method: Composition-based stats. Identities = 81/311 (26%), Positives = 131/311 (42%), Gaps = 55/311 (17%) Query: 20 IHSRYINLRP--IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKL 77 ++S Y + +G G G V +T T +A K + + + + E +M Sbjct: 85 VNSFYTVSKTEILGGGRFGQVHKCEETATGLKLAAKIIK--TRGMKDKEEVKNEISVMNQ 142 Query: 78 VNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN-LCQVI---QMDLDHDRMSYLLYQM 133 ++H N+I L +AF E D+ LVME +D L I +L + Q+ Sbjct: 143 LDHANLIQLYDAF------ESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQI 196 Query: 134 LCGIKHLHSAGIIHRDLKPSNIV-VKAD-CTLKILDFGLARTAGTTFMMTPYVVTRYYRA 191 GI+H+H I+H DLKP NI+ V D +KI+DFGLAR + T + A Sbjct: 197 CEGIRHMHQMYILHLDLKPENILCVNRDAKQIKIIDFGLARRYKPREKLKVNFGTPEFLA 256 Query: 192 PEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQ 251 PEV+ + D+WSVG I ++ G F G + + N I+ Sbjct: 257 PEVVNYDFVSFPTDMWSVGVIAYMLLSGLSPFLGDNDAETLNNIL--------------- 301 Query: 252 PTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISV 311 R +E+ + + + +A+ +SK+L+ + RIS Sbjct: 302 -ACRWDLED-----------------------EEFQDISEEAKEFISKLLIKEKSWRISA 337 Query: 312 DEALKHEYINV 322 EALKH +++ Sbjct: 338 SEALKHPWLSD 348 >5F9E-A nrPDB Length = 353 Score = 235 bits (600), Expect = 2e-62, Method: Composition-based stats. Identities = 87/358 (24%), Positives = 146/358 (40%), Gaps = 70/358 (19%) Query: 8 HYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPF-QNVTHAK 66 +++ +F +H + +G G+ G V A T Q AIK L + + Sbjct: 11 SLQIKLKIEDFELH------KMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVE 64 Query: 67 RAYREFKLMKLV-NHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDA-NLCQVIQM--DLD 122 E +++ L H + + F + NL + VME ++ +L IQ D Sbjct: 65 CTMVEKRVLSLAWEHPFLTHMFCTFQTKENL------FFVMEYLNGGDLMYHIQSCHKFD 118 Query: 123 HDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMT- 181 R ++ +++ G++ LHS GI++RDLK NI++ D +KI DFG+ + T Sbjct: 119 LSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTN 178 Query: 182 PYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGT 241 + T Y APE++LG Y +VD WS G ++ EM+ G F G D + ++ I Sbjct: 179 EFCGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSI------ 232 Query: 242 PSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKML 301 DN R +A++LL K+ Sbjct: 233 -------------------------------------RMDNPFYPRWLEKEAKDLLVKLF 255 Query: 302 VIDPEQRISVD-EALKHEYINV--WYDAEEVDAPAP------EPYDHSVDEREHTVEQ 350 V +PE+R+ V + +H W + E + P P+D S ++E E+ Sbjct: 256 VREPEKRLGVRGDIRQHPLFREINWEELERKEIDPPFRPKVKSPFDCSNFDKEFLNEK 313 >1PHK-A nrPDB Length = 298 Score = 235 bits (599), Expect = 3e-62, Method: Composition-based stats. Identities = 70/321 (21%), Positives = 120/321 (37%), Gaps = 62/321 (19%) Query: 20 IHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLS-------RPFQNVTHAKRAYREF 72 + Y +G G +V T + A+K + + + +E Sbjct: 15 FYENYEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQELREATLKEV 74 Query: 73 KLMKLVN-HKNIIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVI--QMDLDHDRMSY 128 +++ V+ H NII L + + +LV +LM L + ++ L Sbjct: 75 DILRKVSGHPNIIQLKDTYETNTFF------FLVFDLMKKGELFDYLTEKVTLSEKETRK 128 Query: 129 LLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRY 188 ++ +L I LH I+HRDLKP NI++ D +K+ DFG + + T Sbjct: 129 IMRALLEVICALHKLNIVHRDLKPENILLDDDMNIKLTDFGFSCQLDPGEKLREVCGTPS 188 Query: 189 YRAPEVILGM------GYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTP 242 Y APE+I GY + VD+WS G IM ++ G F + I+ Sbjct: 189 YLAPEIIECSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSG---- 244 Query: 243 SPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLV 302 NY P + Y + ++L+S+ LV Sbjct: 245 -------------NYQFGSPEWDDY----------------------SDTVKDLVSRFLV 269 Query: 303 IDPEQRISVDEALKHEYINVW 323 + P++R + +EAL H + + Sbjct: 270 VQPQKRYTAEEALAHPFFQQY 290 >4QMW-A nrPDB Length = 310 Score = 235 bits (599), Expect = 3e-62, Method: Composition-based stats. Identities = 63/311 (20%), Positives = 112/311 (36%), Gaps = 52/311 (16%) Query: 13 VGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREF 72 + + + L IG G+ G V D TQ+ VAIK + +E Sbjct: 20 MQNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDI-QQEI 78 Query: 73 KLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN--LCQVIQMDLDHDRMSYLL 130 ++ + + ++ ++++ME + L + LD +++ +L Sbjct: 79 TVLSQCDSPYVTKYYGSYLKD------TKLWIIMEYLGGGSALDLLEPGPLDETQIATIL 132 Query: 131 YQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTF-MMTPYVVTRYY 189 ++L G+ +LHS IHRD+K +N+++ +K+ DFG+A T +V T ++ Sbjct: 133 REILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFW 192 Query: 190 RAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQR 249 APEVI Y DIWS+G E+ RG + I Sbjct: 193 MAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLI-------------- 238 Query: 250 LQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRI 309 N+ + + + L +P R Sbjct: 239 ----------------------------PKNNPPTLEGNYSKPLKEFVEACLNKEPSFRP 270 Query: 310 SVDEALKHEYI 320 + E LKH++I Sbjct: 271 TAKELLKHKFI 281 >4RLP-A nrPDB Length = 288 Score = 234 bits (598), Expect = 3e-62, Method: Composition-based stats. Identities = 75/328 (22%), Positives = 125/328 (38%), Gaps = 63/328 (19%) Query: 24 YINLRPIGSGAQGIVCAAYDTI---TQQNVAIKKLSRPF--QNVTHAKRAYREFKLMKLV 78 + LR +G G G V T + A+K L + +N E +++ V Sbjct: 7 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEV 66 Query: 79 NHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN-LCQVIQMD--LDHDRMSYLLYQMLC 135 H I+ L+ AF L YL++E + L ++ + D + L ++ Sbjct: 67 KHPFIVDLIYAFQTGGKL------YLILEYLSGGELFMQLEREGIFMEDTACFYLAEISM 120 Query: 136 GIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMT-PYVVTRYYRAPEV 194 + HLH GII+RDLKP NI++ +K+ DFGL + + +T + T Y APE+ Sbjct: 121 ALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEI 180 Query: 195 ILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTV 254 ++ G+ VD WS+G +M +M+ G F G + +KI++ P Q Sbjct: 181 LMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQ------ 234 Query: 255 RNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRI----- 309 +AR+LL K+L + R+ Sbjct: 235 -------------------------------------EARDLLKKLLKRNAASRLGAGPG 257 Query: 310 SVDEALKHEYINVWYDAEEVDAPAPEPY 337 E H + E + P+ Sbjct: 258 DAGEVQAHPFFRHINWEELLARKVEPPF 285 >2WO6-A nrPDB Length = 382 Score = 234 bits (598), Expect = 4e-62, Method: Composition-based stats. Identities = 96/334 (28%), Positives = 146/334 (43%), Gaps = 36/334 (10%) Query: 22 SRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHK 81 RY IG G+ G V AYD + Q+ VAIK + +A E +L++L+N Sbjct: 54 DRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIK---NKKAFLNQAQIEVRLLELMNKH 110 Query: 82 NIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQ----MDLDHDRMSYLLYQMLCGI 137 + +R+ + LV E++ NL +++ + + QM + Sbjct: 111 DTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTAL 170 Query: 138 KHLH--SAGIIHRDLKPSNIVVKA--DCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPE 193 L IIH DLKP NI++ +KI+DFG + G + Y+ +R+YR+PE Sbjct: 171 LFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLG--QRIYQYIQSRFYRSPE 228 Query: 194 VILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPT 253 V+LGM Y +D+WS+GCI+ EM G LF G + +DQ NKI+E LG P P+ + P Sbjct: 229 VLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIP-PAHILDQAPK 287 Query: 254 VRNYVENRP------RYTGYSFDRLFPDGLFPNDNNQNSRRKAS---------------- 291 R + E P + T P G N Sbjct: 288 ARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYL 347 Query: 292 DARNLLSKMLVIDPEQRISVDEALKHEYINVWYD 325 ++L+ +ML DP+ RI AL+H + D Sbjct: 348 KFKDLILRMLDYDPKTRIQPYYALQHSFFKKTAD 381 >2XIK-A nrPDB Length = 294 Score = 234 bits (597), Expect = 5e-62, Method: Composition-based stats. Identities = 65/326 (19%), Positives = 123/326 (37%), Gaps = 59/326 (18%) Query: 1 MTTAQHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQ 60 + +QH V+ + L IG G+ G V D T++ VAIK + Sbjct: 5 LRGFANQHSRVD-------PEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEA 57 Query: 61 NVTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN--LCQVIQ 118 + +E ++ + I ++ ++++ME + L + Sbjct: 58 -EDEIEDIQQEITVLSQCDSPYITRYFGSYLKS------TKLWIIMEYLGGGSALDLLKP 110 Query: 119 MDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTF 178 L+ ++ +L ++L G+ +LHS IHRD+K +N+++ +K+ DFG+A T Sbjct: 111 GPLEETYIATILREILKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQ 170 Query: 179 -MMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIE 237 +V T ++ APEVI Y DIWS+G E+ +G + +++ Sbjct: 171 IKRNTFVGTPFWMAPEVIKQSAYDFKADIWSLGITAIELAKGEPP----NSDLHPMRVLF 226 Query: 238 QLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLL 297 + SP ++ + + + + Sbjct: 227 LIPKNSPPTLE--------------------------------------GQHSKPFKEFV 248 Query: 298 SKMLVIDPEQRISVDEALKHEYINVW 323 L DP R + E LKH++I + Sbjct: 249 EACLNKDPRFRPTAKELLKHKFITRY 274 >3LM0-A nrPDB Length = 327 Score = 234 bits (596), Expect = 6e-62, Method: Composition-based stats. Identities = 70/351 (19%), Positives = 135/351 (38%), Gaps = 57/351 (16%) Query: 11 VEVGDTNFTIHSRY-------INLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVT 63 V++G N S + + +G G +V T Q A K L + + Sbjct: 11 VDLGTENLYFQSMENFNNFYILTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQD 70 Query: 64 HAKRAYREFKLMKLVN-HKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLD 122 E +++L +I L + + + E+ L ++ +M + Sbjct: 71 CRAEILHEIAVLELAKSCPRVINLHEVYENTSEIILILEYAAGGEIFSLCLPELAEM-VS 129 Query: 123 HDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKA---DCTLKILDFGLARTAGTTFM 179 + + L+ Q+L G+ +LH I+H DLKP NI++ + +KI+DFG++R G Sbjct: 130 ENDVIRLIKQILEGVYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACE 189 Query: 180 MTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQL 239 + + T Y APE++ T D+W++G I ++ F G D+ + + I + Sbjct: 190 LREIMGTPEYLAPEILNYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQ-- 247 Query: 240 GTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSK 299 + + + + + A + + Sbjct: 248 -------------------------------------VNVDYSEETFSSVSQLATDFIQS 270 Query: 300 MLVIDPEQRISVDEALKHEYINVW-----YDAEEVDAPAPEPYDHSVDERE 345 +LV +PE+R + + L H ++ W + EE + + + DHSV E Sbjct: 271 LLVKNPEKRPTAEICLSHSWLQQWDFENLFHPEETSS-SSQTQDHSVRSSE 320 >1FOT-A nrPDB Length = 318 Score = 234 bits (596), Expect = 7e-62, Method: Composition-based stats. Identities = 67/345 (19%), Positives = 136/345 (39%), Gaps = 60/345 (17%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQ-NVTHAKRAYREFKLMKLVNHKN 82 + LR +G+G+ G V + A+K L + + + E ++ +V H Sbjct: 8 FQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTHPF 67 Query: 83 IIGLLNAFTPQRNLEEFQDVYLVMELMDAN-LCQVIQM--DLDHDRMSYLLYQMLCGIKH 139 II + F + Q ++++M+ ++ L +++ + + ++ +++ Sbjct: 68 IIRMWGTFQ------DAQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEY 121 Query: 140 LHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMG 199 LHS II+RDLKP NI++ + +KI DFG A+ + T Y APEV+ Sbjct: 122 LHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPD--VTYTLCGTPDYIAPEVVSTKP 179 Query: 200 YTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVE 259 Y +++D WS G ++ EM+ G F ++ + + KI+ P F Sbjct: 180 YNKSIDWWSFGILIYEMLAGYTPFYDSNTMKTYEKILNAELRFPPFF------------- 226 Query: 260 NRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRI-----SVDEA 314 D ++LLS+++ D QR+ ++ Sbjct: 227 ------------------------------NEDVKDLLSRLITRDLSQRLGNLQNGTEDV 256 Query: 315 LKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYEEV 359 H + + + PY+ + + + Q+ + E++ Sbjct: 257 KNHPWFKEVVWEKLLSRNIETPYEPPIQQGQGDTSQFDKYPEEDI 301 >3KN6-A nrPDB Length = 325 Score = 234 bits (596), Expect = 7e-62, Method: Composition-based stats. Identities = 79/346 (22%), Positives = 146/346 (42%), Gaps = 63/346 (18%) Query: 3 TAQHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNV 62 + +QHY +++ D +P+G G+ I + Q A+K +S+ + Sbjct: 4 SPFYQHYDLDLKD------------KPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEAN 51 Query: 63 THAKRAYREFKLMKLVN-HKNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN-LCQVIQMD 120 T +E +KL H NI+ L F Q + +LVMEL++ L + I+ Sbjct: 52 TQ-----KEITALKLCEGHPNIVKLHEVFHDQLHT------FLVMELLNGGELFERIKKK 100 Query: 121 --LDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVV---KADCTLKILDFGLAR-TA 174 SY++ +++ + H+H G++HRDLKP N++ + +KI+DFG AR Sbjct: 101 KHFSETEASYIMRKLVSAVSHMHDVGVVHRDLKPENLLFTDENDNLEIKIIDFGFARLKP 160 Query: 175 GTTFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNK 234 + T +Y APE++ GY E+ D+WS+G I+ M+ G V F D Sbjct: 161 PDNQPLKTPCFTLHYAAPELLNQNGYDESCDLWSLGVILYTMLSGQVPFQSHD------- 213 Query: 235 IIEQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDAR 294 + L T + + + +SF+ + + + +A+ Sbjct: 214 -------------RSLTCTSAVEIMKKIKKGDFSFE------------GEAWKNVSQEAK 248 Query: 295 NLLSKMLVIDPEQRISVDEALKHEYINVWYDAEEVDAPAPEPYDHS 340 +L+ +L +DP +R+ + +E++ P+ S Sbjct: 249 DLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQLSSNPLMTPDILGSS 294 >3DAK-A nrPDB Length = 290 Score = 233 bits (595), Expect = 7e-62, Method: Composition-based stats. Identities = 78/320 (24%), Positives = 135/320 (42%), Gaps = 58/320 (18%) Query: 21 HSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNH 80 Y IGSGA +V AAY ++ VAIK+++ + T +E + M +H Sbjct: 9 RDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLE-KCQTSMDELLKEIQAMSQCHH 67 Query: 81 KNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN-LCQVIQ----------MDLDHDRMSYL 129 NI+ +F + +++LVM+L+ + +I+ LD ++ + Sbjct: 68 PNIVSYYTSFVVK------DELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATI 121 Query: 130 LYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMT------PY 183 L ++L G+++LH G IHRD+K NI++ D +++I DFG++ T +T + Sbjct: 122 LREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTF 181 Query: 184 VVTRYYRAPEVILG-MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTP 242 V T + APEV+ GY DIWS G E+ G + Sbjct: 182 VGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYH------------------ 223 Query: 243 SPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLV 302 M+ L T++N P + + ++ R ++S L Sbjct: 224 KYPPMKVLMLTLQNDP---------------PSLETGVQDKEMLKKYGKSFRKMISLCLQ 268 Query: 303 IDPEQRISVDEALKHEYINV 322 DPE+R + E L+H++ Sbjct: 269 KDPEKRPTAAELLRHKFFQK 288 >4B6L-A nrPDB Length = 281 Score = 232 bits (593), Expect = 1e-61, Method: Composition-based stats. Identities = 72/313 (23%), Positives = 120/313 (38%), Gaps = 54/313 (17%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRP-FQNVTHAKRAYREFKLMKLVNHKN 82 Y+ R +G G A DT T A+K + + ++ E +L + + H++ Sbjct: 11 YLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRH 70 Query: 83 IIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVI---QMDLDHDRMSYLLYQMLCGIKH 139 I+ + E+ ++Y+ +EL I + L + Y L Q+L G+K+ Sbjct: 71 IVRF------SHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKY 124 Query: 140 LHSAGIIHRDLKPSNIVVKADCTLKILDFGLA-RTAGTTFMMTPYVVTRYYRAPEVILGM 198 LH GI+HRDLK N + + LK+ DFGLA R T Y APEV+L Sbjct: 125 LHQRGILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQ 184 Query: 199 GYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYV 258 G+ D+WS+GC+M ++ G F D + + I + T S + + + Sbjct: 185 GHGPEADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAIL 244 Query: 259 ENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHE 318 PR R S+D+ L+H+ Sbjct: 245 RASPR-------------------------------------------DRPSIDQILRHD 261 Query: 319 YINVWYDAEEVDA 331 + Y + + Sbjct: 262 FFTKGYTPDRLPI 274 >2JDO-A nrPDB Length = 342 Score = 232 bits (593), Expect = 1e-61, Method: Composition-based stats. Identities = 68/317 (21%), Positives = 122/317 (38%), Gaps = 62/317 (19%) Query: 15 DTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRP-FQNVTHAKRAYREFK 73 D T++ + L+ +G G G V + T + A+K L + E + Sbjct: 4 DPKVTMND-FDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESR 62 Query: 74 LMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVI---QMDLDHDRMSYLL 130 +++ H + L AF L VME + + +R + Sbjct: 63 VLQNTRHPFLTALKYAFQTHDRL------CFVMEYANGGELFFHLSRERVFTEERARFYG 116 Query: 131 YQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLART-AGTTFMMTPYVVTRYY 189 +++ +++LHS +++RD+K N+++ D +KI DFGL + M + T Y Sbjct: 117 AEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEY 176 Query: 190 RAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKI-IEQLGTPSPSFMQ 248 APEV+ Y VD W +G +M EM+ G + F DH + I +E++ P Sbjct: 177 LAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFP------ 230 Query: 249 RLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQR 308 R + +A++LL+ +L DP+QR Sbjct: 231 --------------------------------------RTLSPEAKSLLAGLLKKDPKQR 252 Query: 309 I-----SVDEALKHEYI 320 + E ++H + Sbjct: 253 LGGGPSDAKEVMEHRFF 269 >5X8I-B nrPDB Length = 346 Score = 232 bits (593), Expect = 1e-61, Method: Composition-based stats. Identities = 87/348 (25%), Positives = 152/348 (43%), Gaps = 47/348 (13%) Query: 8 HYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAY-DTITQQNVAIKKLSRPFQNVTHAK 66 H + GD + +RY + +G GA G V ++VA+K + + + + Sbjct: 2 HLICQSGDV---LSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDR---YCE 55 Query: 67 RAYREFKLMKLVN--HKN----IIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQM- 119 A E ++++ +N N + +L F E + +V EL+ + I+ Sbjct: 56 AARSEIQVLEHLNTTDPNSTFRCVQMLEWF------EHHGHICIVFELLGLSTYDFIKEN 109 Query: 120 ---DLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKA----------------- 159 D + + YQ+ + LHS + H DLKP NI+ Sbjct: 110 GFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERT 169 Query: 160 --DCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMI 217 + +K++DFG A + V TR+YRAPEVIL +G+++ D+WS+GCI+ E Sbjct: 170 LINPDIKVVDFGSATYDDEHH--STLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYY 227 Query: 218 RGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFD-RLFPDG 276 G +FP D + ++E++ P P M + + + +R + +S R Sbjct: 228 LGFTVFPTHDSKEHL-AMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRA 286 Query: 277 LFPNDNNQNSRRKASD-ARNLLSKMLVIDPEQRISVDEALKHEYINVW 323 P S+ + +L+ KML DP +RI++ EALKH + ++ Sbjct: 287 CKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLL 334 >5D7A-A nrPDB Length = 308 Score = 232 bits (592), Expect = 2e-61, Method: Composition-based stats. Identities = 66/327 (20%), Positives = 123/327 (37%), Gaps = 56/327 (17%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKL-VNHKN 82 + + +G+G G V T Q AIK + + +E ++K +H+N Sbjct: 19 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGD---EEEEIKQEINMLKKYSHHRN 75 Query: 83 IIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQMD----LDHDRMSYLLYQMLCGI 137 I AF + ++LVME ++ +I+ L + ++Y+ ++L G+ Sbjct: 76 IATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGL 135 Query: 138 KHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTF-MMTPYVVTRYYRAPEVIL 196 HLH +IHRD+K N+++ + +K++DFG++ T ++ T Y+ APEVI Sbjct: 136 SHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIA 195 Query: 197 -----GMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQ 251 Y D+WS+G EM G + I P+P + Sbjct: 196 CDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPR---NPAPRLKSKKW 252 Query: 252 PTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISV 311 + ++ + LV + QR + Sbjct: 253 --------------------------------------SKKFQSFIESCLVKNHSQRPAT 274 Query: 312 DEALKHEYINVWYDAEEVDAPAPEPYD 338 ++ +KH +I + +V + D Sbjct: 275 EQLMKHPFIRDQPNERQVRIQLKDHID 301 >4IAN-A nrPDB Length = 358 Score = 232 bits (592), Expect = 2e-61, Method: Composition-based stats. Identities = 94/344 (27%), Positives = 152/344 (44%), Gaps = 31/344 (9%) Query: 3 TAQHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTIT-QQNVAIKKLSRPFQN 61 T +Y V +G+ + RY G G V A D Q VA+K + N Sbjct: 14 TDAEGYYRVNIGEV---LDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIR---NN 67 Query: 62 VTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQM-- 119 K +E + +K +N + + R+ Q + LV E + NL +V++ Sbjct: 68 ELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYG 127 Query: 120 ---DLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTL-KILDFGLARTAG 175 L + Q+ +K L I+H D+KP NI+V T+ K+ DFG A Sbjct: 128 KDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASHVA 187 Query: 176 TTFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQW--- 232 +TPY+V+R+YRAPE+I+G Y +D+WSVGC + E+ G +LFPG + Sbjct: 188 DND-ITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLA 246 Query: 233 --------NKIIEQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFP------DGLF 278 NK+I + F Q L + R + P D + Sbjct: 247 MDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLADLIG 306 Query: 279 PNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEYINV 322 ++ R+K ++LL ++L++DP +RIS+++AL+H +I Sbjct: 307 CQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQE 350 >3HDN-A nrPDB Length = 373 Score = 232 bits (591), Expect = 2e-61, Method: Composition-based stats. Identities = 70/331 (21%), Positives = 130/331 (39%), Gaps = 29/331 (8%) Query: 21 HSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKL-SRPFQNVTHAKRAYREFKLM-KLV 78 S + L+ IG G+ G V A + A+K L + K E ++ K V Sbjct: 37 PSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNV 96 Query: 79 NHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN-LCQVIQMD--LDHDRMSYLLYQMLC 135 H ++GL +F L Y V++ ++ L +Q + R + ++ Sbjct: 97 KHPFLVGLHFSFQTADKL------YFVLDYINGGELFYHLQRERCFLEPRARFYAAEIAS 150 Query: 136 GIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLART-AGTTFMMTPYVVTRYYRAPEV 194 + +LHS I++RDLKP NI++ + + + DFGL + + + T Y APEV Sbjct: 151 ALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEV 210 Query: 195 ILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTV 254 + Y VD W +G ++ EM+ G F + + ++ I+ + P+ + + Sbjct: 211 LHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLL 270 Query: 255 RNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLV--IDPEQRISVD 312 ++ + D + N +L++K + +P +S Sbjct: 271 EGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWD-------DLINKKITPPFNPN--VSGP 321 Query: 313 EALKHEYINVWYDAEEVDAPAPEPYDHSVDE 343 L+H +D E + P P + D Sbjct: 322 NDLRH------FDPEFTEEPVPNAIGKAPDS 346 >4YNZ-A nrPDB Length = 342 Score = 231 bits (590), Expect = 3e-61, Method: Composition-based stats. Identities = 69/319 (21%), Positives = 128/319 (40%), Gaps = 57/319 (17%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNI 83 Y + +G G G+V +T Q VAIK ++R + + + RE ++KL+ H ++ Sbjct: 12 YRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHV 71 Query: 84 IGLLNAFTPQRNLEEFQDVYLVMELMDAN-LCQVI--QMDLDHDRMSYLLYQMLCGIKHL 140 + L + + E + +YLV+E + L + + L Q++ + Sbjct: 72 LKLHDVY------ENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFC 125 Query: 141 HSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGY 200 HS I HRDLKP N+++ ++I DFG+A ++ + +Y PEVI G Y Sbjct: 126 HSHSICHRDLKPENLLLDERNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKY 185 Query: 201 T-ENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVE 259 D+WS G I+ ++ G + F + K+ + V Sbjct: 186 DGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKV-------------------KRGVF 226 Query: 260 NRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEY 319 + P + D ++LL M+ +D +R++++ KH Sbjct: 227 HMPHF------------------------IPPDCQSLLRGMIEVDAARRLTLEHIQKH-- 260 Query: 320 INVWYDAEEVDAPAPEPYD 338 +WY + + +P Sbjct: 261 --IWYIGGKNEPEPEQPIP 277 >4CSV-A nrPDB Length = 275 Score = 231 bits (590), Expect = 3e-61, Method: Composition-based stats. Identities = 59/264 (22%), Positives = 103/264 (39%), Gaps = 23/264 (8%) Query: 17 NFTIHSRYINL-RPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLM 75 + I I L R +GSG G V VA+K L + + +E ++M Sbjct: 5 KWEIPRSEITLERKLGSGQFGEVYEGKWRNYNIEVAVKTLK---EGTMSVEEFLQEAQIM 61 Query: 76 KLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQ----MDLDHDRMSYLL 130 K + H N++ L T + +Y++ E M +L ++ ++ + + Sbjct: 62 KKLKHPNLVQLYGVCTKEP------PIYIITEYMSHGSLLDYLRDCEGHTVNAQALLDMA 115 Query: 131 YQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFM--MTPYVVTRY 188 Q+ G+ +L S IHRDL N +V + +K+ DFGLAR Sbjct: 116 AQVASGMAYLESQNFIHRDLAARNCLVGENNVVKVADFGLARLINEDEYTARAGAKFPIK 175 Query: 189 YRAPEVILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQWNKIIEQLGTPSP--- 244 + APE I ++ D+W+ G ++ E+ G V +PG + ++ P P Sbjct: 176 WTAPEAISYNRFSIKSDVWAFGILLWEIFTYGQVPYPGMSGSEVIEQVERGYRMPRPQGC 235 Query: 245 --SFMQRLQPTVRNYVENRPRYTG 266 + + E RP + Sbjct: 236 PEEIYELMLQCWNKSPEERPTFAE 259 >3HKO-A nrPDB Length = 345 Score = 231 bits (590), Expect = 3e-61, Method: Composition-based stats. Identities = 81/380 (21%), Positives = 143/380 (37%), Gaps = 103/380 (27%) Query: 2 TTAQHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSR---P 58 + ++ ++ G + + +Y IG G+ G+V A + T+ AIK +++ Sbjct: 9 SGRENLYFQ---GGSLLELQKKYHLKGAIGQGSYGVVRVAIENQTRAIRAIKIMNKNKIR 65 Query: 59 FQNVTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN-LCQVI 117 N +R E +LMK ++H NI L + + Q + LVMEL L + Sbjct: 66 QINPKDVERIKTEVRLMKKLHHPNIARLYEVYEDE------QYICLVMELCHGGHLLDKL 119 Query: 118 QMDLD------------------------------------------HDRMSYLLYQMLC 135 + +D +S ++ Q+ Sbjct: 120 NVFIDDSTGKCAMDVVKTQICPCPECNEEAINGSIHGFRESLDFVQREKLISNIMRQIFS 179 Query: 136 GIKHLHSAGIIHRDLKPSNIVVKAD--CTLKILDFGLARTA-----GTTFMMTPYVVTRY 188 + +LH+ GI HRD+KP N + + +K++DFGL++ G + MT T Y Sbjct: 180 ALHYLHNQGICHRDIKPENFLFSTNKSFEIKLVDFGLSKEFYKLNNGEYYGMTTKAGTPY 239 Query: 189 YRAPEVIL--GMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSF 246 + APEV+ Y D WS G ++ ++ G V FPG + D ++++ + Sbjct: 240 FVAPEVLNTTNESYGPKCDAWSAGVLLHLLLMGAVPFPGVNDADTISQVLNKKLCFENPN 299 Query: 247 MQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPE 306 L P AR+LLS +L + + Sbjct: 300 YNVLSPL---------------------------------------ARDLLSNLLNRNVD 320 Query: 307 QRISVDEALKHEYINVWYDA 326 +R AL+H +I+ + D Sbjct: 321 ERFDAMRALQHPWISQFSDK 340 >4FZF-B nrPDB Length = 283 Score = 231 bits (589), Expect = 4e-61, Method: Composition-based stats. Identities = 65/300 (21%), Positives = 112/300 (37%), Gaps = 52/300 (17%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNI 83 + L IG G+ G V D TQQ VAIK + +E ++ + + Sbjct: 10 FTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIED-IQQEITVLSQCDSSYV 68 Query: 84 IGLLNAFTPQRNLEEFQDVYLVMELMDANL-CQVIQ-MDLDHDRMSYLLYQMLCGIKHLH 141 ++ L +++ME + +++ D +++ +L ++L G+ +LH Sbjct: 69 TKYYGSYLKGSKL------WIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLH 122 Query: 142 SAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTF-MMTPYVVTRYYRAPEVILGMGY 200 S IHRD+K +N+++ +K+ FG+A T +V T ++ APEVI Y Sbjct: 123 SEKKIHRDIKAANVLLSEQGDVKLAAFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAY 182 Query: 201 TENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVEN 260 DIWS+G E+ +G + I +N Sbjct: 183 DSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLI----------------------PKN 220 Query: 261 RPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEYI 320 P F + F + + L DP R + E LKH++I Sbjct: 221 NPPTLVGDFTKSF--------------------KEFIDACLNKDPSFRPTAKELLKHKFI 260 >1KOB-A nrPDB Length = 387 Score = 231 bits (589), Expect = 4e-61, Method: Composition-based stats. Identities = 63/321 (19%), Positives = 128/321 (39%), Gaps = 53/321 (16%) Query: 19 TIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLV 78 +++ Y L +GSGA G+V + T + K ++ P+ E +M + Sbjct: 48 SVYDYYDILEELGSGAFGVVHRCVEKATGRVFVAKFINTPY--PLDKYTVKNEISIMNQL 105 Query: 79 NHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN-LCQVI---QMDLDHDRMSYLLYQML 134 +H +I L +AF + ++ L++E + L I + + + Q Sbjct: 106 HHPKLINLHDAFEDKY------EMVLILEFLSGGELFDRIAAEDYKMSEAEVINYMRQAC 159 Query: 135 CGIKHLHSAGIIHRDLKPSNIVVKAD--CTLKILDFGLARTAGTTFMMTPYVVTRYYRAP 192 G+KH+H I+H D+KP NI+ + ++KI+DFGLA ++ T + AP Sbjct: 160 EGLKHMHEHSIVHLDIKPENIMCETKKASSVKIIDFGLATKLNPDEIVKVTTATAEFAAP 219 Query: 193 EVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQP 252 E++ D+W++G + ++ G F G D ++ Sbjct: 220 EIVDREPVGFYTDMWAIGVLGYVLLSGLSPFAGEDDLETL-------------------- 259 Query: 253 TVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVD 312 +N + +F + +A++ + +L +P +R++V Sbjct: 260 --QNVKRCDWEFDEDAFSS-----------------VSPEAKDFIKNLLQKEPRKRLTVH 300 Query: 313 EALKHEYINVWYDAEEVDAPA 333 +AL+H ++ + P+ Sbjct: 301 DALEHPWLKGDHSNLTSRIPS 321 >3DB8-A nrPDB Length = 317 Score = 231 bits (588), Expect = 5e-61, Method: Composition-based stats. Identities = 71/314 (22%), Positives = 116/314 (36%), Gaps = 54/314 (17%) Query: 22 SRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYR-EFKLMKLVNH 80 RY+ R +G G D T++ A K + + H K E + K +++ Sbjct: 42 KRYMRGRFLGKGGFAKCYEITDMDTKEVFAGKVVPKSMLLKPHQKEKMSTEIAIHKSLDN 101 Query: 81 KNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMD---LDHDRMSYLLYQMLCGI 137 +++G F VY+V+E+ + + Y + Q + G+ Sbjct: 102 PHVVGFHGFFEDDDF------VYVVLEICRRRSLLELHKRRKAVTEPEARYFMRQTIQGV 155 Query: 138 KHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAG-TTFMMTPYVVTRYYRAPEVIL 196 ++LH+ +IHRDLK N+ + D +KI DFGLA T Y APEV+ Sbjct: 156 QYLHNNRVIHRDLKLGNLFLNDDMDVKIGDFGLATKIEFDGERKKDLCGTPNYIAPEVLC 215 Query: 197 GMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRN 256 G++ VDIWS+GCI+ ++ G F + + + +I + Sbjct: 216 KKGHSFEVDIWSLGCILYTLLVGKPPFETSCLKETYIRIKK------------------- 256 Query: 257 YVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALK 316 + R A L+ +ML DP R SV E L Sbjct: 257 ------------------------NEYSVPRHINPVASALIRRMLHADPTLRPSVAELLT 292 Query: 317 HEYINVWYDAEEVD 330 E+ Y + Sbjct: 293 DEFFTSGYAPMRLP 306 >4JXF-A nrPDB Length = 266 Score = 230 bits (587), Expect = 7e-61, Method: Composition-based stats. Identities = 65/311 (20%), Positives = 125/311 (40%), Gaps = 58/311 (18%) Query: 20 IHSRYINLRP---IGSGAQGIVCAAYDTITQQNVAIKKL-SRPFQNVTHAKRAYREFKLM 75 I + + + +G G+ V A T VAIK + + +R E K+ Sbjct: 2 IGEKIEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIH 61 Query: 76 KLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELM-DANLCQVIQ---MDLDHDRMSYLLY 131 + H +I+ L N F E+ VYLV+E+ + + + ++ + + ++ Sbjct: 62 CQLKHPSILELYNYF------EDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMH 115 Query: 132 QMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAG-TTFMMTPYVVTRYYR 190 Q++ G+ +LHS GI+HRDL SN+++ + +KI DFGLA T Y Sbjct: 116 QIITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYI 175 Query: 191 APEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRL 250 +PE+ + D+WS+GC+ ++ G F + NK++ Sbjct: 176 SPEIATRSAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVV-------------- 221 Query: 251 QPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRIS 310 + + + +A++L+ ++L +P R+S Sbjct: 222 -----------------------------LADYEMPSFLSIEAKDLIHQLLRRNPADRLS 252 Query: 311 VDEALKHEYIN 321 + L H +++ Sbjct: 253 LSSVLDHPFMS 263 >5DBX-A nrPDB Length = 328 Score = 229 bits (585), Expect = 1e-60, Method: Composition-based stats. Identities = 79/322 (24%), Positives = 132/322 (40%), Gaps = 58/322 (18%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNI 83 Y IGSGA +V AA Q+ VAIK+++ + T +E + M +H N+ Sbjct: 13 YELQEVIGSGATAVVQAALCKPRQERVAIKRINLE-KCQTSMDELLKEIQAMSQCSHPNV 71 Query: 84 IGLLNAFTPQRNLEEFQDVYLVMELMDAN-LCQVIQM----------DLDHDRMSYLLYQ 132 + +F + +++LVM+L+ + +I+ L+ ++ +L + Sbjct: 72 VTYYTSFVVK------DELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKE 125 Query: 133 MLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMT------PYVVT 186 +L G+ +LH G IHRDLK NI++ D +++I DFG++ T +T +V T Sbjct: 126 VLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKDFVGT 185 Query: 187 RYYRAPEVILG-MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPS 245 + APEV+ GY D+WS G E+ G + + Sbjct: 186 PCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLML----------- 234 Query: 246 FMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDP 305 +Q PT+ VE++ Y R LLS L DP Sbjct: 235 TLQNDPPTLETGVEDKEMMKKY----------------------GKSFRKLLSLCLQKDP 272 Query: 306 EQRISVDEALKHEYINVWYDAE 327 +R + E LK ++ + E Sbjct: 273 SKRPTAAELLKCKFFQKAKNRE 294 >2HW6-A nrPDB Length = 307 Score = 229 bits (585), Expect = 1e-60, Method: Composition-based stats. Identities = 76/323 (23%), Positives = 129/323 (39%), Gaps = 53/323 (16%) Query: 20 IHSRYINL-RPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLV 78 Y +G GA V A + A+K + + + R +RE + + Sbjct: 10 FEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHS--RSRVFREVETLYQC 67 Query: 79 N-HKNIIGLLNAFTPQRNLEEFQDVYLVME-LMDANLCQVIQMD--LDHDRMSYLLYQML 134 +KNI+ L+ F YLV E L ++ IQ + S ++ + Sbjct: 68 QGNKNILELIEFFEDDTRF------YLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVA 121 Query: 135 CGIKHLHSAGIIHRDLKPSNIVVKAD---CTLKILDFGL--------ARTAGTTFMMTPY 183 + LH+ GI HRDLKP NI+ ++ +KI DF L + T TT +T Sbjct: 122 AALDFLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTP 181 Query: 184 VVTRYYRAPEVI-----LGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQ 238 + Y APEV+ Y + D+WS+G ++ M+ G F G D Sbjct: 182 CGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGAD----CGWD 237 Query: 239 LGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLS 298 G +L +++ P +++ +S+A++L+S Sbjct: 238 RGEVCRVCQNKLFESIQEGKYEFP--------------------DKDWAHISSEAKDLIS 277 Query: 299 KMLVIDPEQRISVDEALKHEYIN 321 K+LV D +QR+S + L+H ++ Sbjct: 278 KLLVRDAKQRLSAAQVLQHPWVQ 300 >3TXO-A nrPDB Length = 353 Score = 228 bits (581), Expect = 3e-60, Method: Composition-based stats. Identities = 71/336 (21%), Positives = 125/336 (37%), Gaps = 61/336 (18%) Query: 22 SRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRP-FQNVTHAKRAYREFKLMKLV-N 79 + +R +G G+ G V A T A+K L + + E +++ L N Sbjct: 23 DNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARN 82 Query: 80 HKNIIGLLNAFTPQRNLEEFQDVYLVMELMDA-NLCQVIQM--DLDHDRMSYLLYQMLCG 136 H + L F L + VME ++ +L IQ D R + +++ Sbjct: 83 HPFLTQLFCCFQTPDRL------FFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISA 136 Query: 137 IKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMT-PYVVTRYYRAPEVI 195 + LH GII+RDLK N+++ + K+ DFG+ + + T + T Y APE++ Sbjct: 137 LMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEIL 196 Query: 196 LGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVR 255 M Y VD W++G ++ EM+ G F + D + I+ Sbjct: 197 QEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILND----------------- 239 Query: 256 NYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRI-SVDE- 313 + ++P L DA +L + +P R+ S+ + Sbjct: 240 --------------EVVYPTWLH------------EDATGILKSFMTKNPTMRLGSLTQG 273 Query: 314 ----ALKHEYINVWYDAEEVDAPAPEPYDHSVDERE 345 L+H + A+ P+ + RE Sbjct: 274 GEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSRE 309 >5KKR-C nrPDB Length = 395 Score = 228 bits (581), Expect = 4e-60, Method: Composition-based stats. Identities = 76/328 (23%), Positives = 144/328 (43%), Gaps = 23/328 (7%) Query: 11 VEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYR 70 +VG+ + + +G+G G+V + +A K + + + R Sbjct: 60 QKVGELK---DDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIK-PAIRNQIIR 115 Query: 71 EFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN-LCQVIQM--DLDHDRMS 127 E +++ N I+G AF ++ + ME MD L QV++ + + Sbjct: 116 ELQVLHECNSPYIVGFYGAFYSDG------EISICMEHMDGGSLDQVLKKAGRIPEQILG 169 Query: 128 YLLYQMLCGIKHL-HSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVT 186 + ++ G+ +L I+HRD+KPSNI+V + +K+ DFG++ + M +V T Sbjct: 170 KVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS-MANSFVGT 228 Query: 187 RYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHID---QWNKIIEQLGTPS 243 R Y +PE + G Y+ DIWS+G + EM G P D + + +E + Sbjct: 229 RSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAET 288 Query: 244 PSFMQRLQPTVRNY-VENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLV 302 P + + +Y +++RP + + P S + + ++ ++K L+ Sbjct: 289 PPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPP---KLPSAVFSLEFQDFVNKCLI 345 Query: 303 IDPEQRISVDEALKHEYINVWYDAEEVD 330 +P +R + + + H +I DAEEVD Sbjct: 346 KNPAERADLKQLMVHAFIK-RSDAEEVD 372 >6HXF-B nrPDB Length = 302 Score = 227 bits (578), Expect = 8e-60, Method: Composition-based stats. Identities = 68/327 (20%), Positives = 128/327 (39%), Gaps = 63/327 (19%) Query: 5 QHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTH 64 +++H ++ + + + +G GA G V A + T A K + ++ Sbjct: 7 EYEHVRRDLDP-----NEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVI--ETKSEEE 59 Query: 65 AKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLD-- 122 + E +++ +H I+ LL A+ L ++++E I ++LD Sbjct: 60 LEDYIVEIEILATCDHPYIVKLLGAYYHDGKL------WIMIEFCPGGAVDAIMLELDRG 113 Query: 123 --HDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGL-ARTAGTTFM 179 ++ + QML + LHS IIHRDLK N+++ + +++ DFG+ A+ T Sbjct: 114 LTEPQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQK 173 Query: 180 MTPYVVTRYYRAPEVIL-----GMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNK 234 ++ T Y+ APEV++ Y DIWS+G + EM + + + K Sbjct: 174 RDSFIGTPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLK 233 Query: 235 IIEQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDAR 294 I + P L P+ + + R Sbjct: 234 IAK---------------------------------SDPPTLLTPSKW-------SVEFR 253 Query: 295 NLLSKMLVIDPEQRISVDEALKHEYIN 321 + L L +PE R S + L+H +++ Sbjct: 254 DFLKIALDKNPETRPSAAQLLEHPFVS 280 >6CMJ-A nrPDB Length = 321 Score = 226 bits (576), Expect = 1e-59, Method: Composition-based stats. Identities = 78/345 (22%), Positives = 139/345 (40%), Gaps = 61/345 (17%) Query: 6 HQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRP------- 58 H+ G + +Y IG G+ G+V AY+ A+K LS+ Sbjct: 18 QGHHVSITGMQDCVQLDQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAG 77 Query: 59 --FQNVTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQV 116 Q ++ Y+E ++K ++H N++ L+ +Y+V EL++ Sbjct: 78 GCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNE----DHLYMVFELVNQGPVME 133 Query: 117 IQ--MDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTA 174 + L D+ + ++ GI++LH IIHRD+KPSN++V D +KI DFG++ Sbjct: 134 VPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEF 193 Query: 175 -GTTFMMTPYVVTRYYRAPEVILGMG---YTENVDIWSVGCIMGEMIRGGVLFPGTDHID 230 G+ +++ V T + APE + + +D+W++G + + G F + Sbjct: 194 KGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMC 253 Query: 231 QWNKIIEQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKA 290 +KI S FPD A Sbjct: 254 LHSKI-------------------------------KSQALEFPD----------QPDIA 272 Query: 291 SDARNLLSKMLVIDPEQRISVDEALKHEYINVWYDAEEVDAPAPE 335 D ++L+++ML +PE RI V E H ++ + AE + + Sbjct: 273 EDLKDLITRMLDKNPESRIVVPEIKLHPWVT-RHGAEPLPSEDEN 316 >2OU7-A nrPDB Length = 335 Score = 226 bits (576), Expect = 1e-59, Method: Composition-based stats. Identities = 66/309 (21%), Positives = 114/309 (36%), Gaps = 54/309 (17%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQ-NVTHAKRAYREFKLMKLVNHKNIIGLLN 88 +G G D T++ A K + + ++ E + + + H++++G Sbjct: 49 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 108 Query: 89 AFTPQRNLEEFQDVYLVMELMDANLCQVIQMD---LDHDRMSYLLYQMLCGIKHLHSAGI 145 F V++V+EL + L Y L Q++ G ++LH + Sbjct: 109 FFEDNDF------VFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRV 162 Query: 146 IHRDLKPSNIVVKADCTLKILDFGLA-RTAGTTFMMTPYVVTRYYRAPEVILGMGYTENV 204 IHRDLK N+ + D +KI DFGLA + T Y APEV+ G++ V Sbjct: 163 IHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGHSFEV 222 Query: 205 DIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENRPRY 264 D+WS+GCIM ++ G F + + + +I + Sbjct: 223 DVWSIGCIMYTLLVGKPPFETSCLKETYLRIKK--------------------------- 255 Query: 265 TGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEYINVWY 324 + + A +L+ KML DP R +++E L E+ Y Sbjct: 256 ----------------NEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGY 299 Query: 325 DAEEVDAPA 333 + Sbjct: 300 IPARLPITC 308 >6FYV-A nrPDB Length = 337 Score = 226 bits (575), Expect = 2e-59, Method: Composition-based stats. Identities = 84/344 (24%), Positives = 148/344 (43%), Gaps = 39/344 (11%) Query: 8 HYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDT-ITQQNVAIKKLSRPFQNVTHAK 66 H + GD + +RY + +G GA G V D + +VA+K + + + + Sbjct: 3 HLICQSGDV---LRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGR---YRE 56 Query: 67 RAYREFKLMKLVNH--KNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQM----D 120 A E ++++ +N N + + V +V EL+ + I+ Sbjct: 57 AARSEIQVLEHLNSTDPNSV--FRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLP 114 Query: 121 LDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKA-------------------DC 161 D + + YQ+ I LH + H DLKP NI+ + Sbjct: 115 FQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNT 174 Query: 162 TLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGV 221 +K++DFG A + V TR+YRAPEVIL +G+++ D+WS+GCI+ E G Sbjct: 175 DIKVVDFGSATYDDEHH--STLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFT 232 Query: 222 LFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFD-RLFPDGLFPN 280 +F D + ++E++ P P M + + + N+ + +S R P Sbjct: 233 VFQTHDSKEHL-AMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPL 291 Query: 281 DNNQNSRRKASD-ARNLLSKMLVIDPEQRISVDEALKHEYINVW 323 + + +L+ +ML DP QRI++DEAL+H + ++ Sbjct: 292 KEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLL 335 >4APC-A nrPDB Length = 350 Score = 225 bits (574), Expect = 2e-59, Method: Composition-based stats. Identities = 73/314 (23%), Positives = 127/314 (40%), Gaps = 56/314 (17%) Query: 11 VEVGDTNFTIHS--RYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRA 68 V++G N S +Y+ L+ IG G+ G T + IK+++ + + + Sbjct: 11 VDLGTENLYFQSMEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREES 70 Query: 69 YREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQMD----LDH 123 RE ++ + H NI+ +F EE +Y+VM+ + +L + I Sbjct: 71 RREVAVLANMKHPNIVQYRESF------EENGSLYIVMDYCEGGDLFKRINAQKGVLFQE 124 Query: 124 DRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPY 183 D++ Q+ +KH+H I+HRD+K NI + D T+++ DFG+AR +T + Sbjct: 125 DQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARA 184 Query: 184 V-VTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTP 242 T YY +PE+ Y DIW++GC++ E+ F + KII P Sbjct: 185 CIGTPYYLSPEICENKPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPP 244 Query: 243 SPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLV 302 S + D R+L+S++ Sbjct: 245 ------------------------------------------VSLHYSYDLRSLVSQLFK 262 Query: 303 IDPEQRISVDEALK 316 +P R SV+ L+ Sbjct: 263 RNPRDRPSVNSILE 276 >1U5R-A nrPDB Length = 348 Score = 225 bits (574), Expect = 2e-59, Method: Composition-based stats. Identities = 73/342 (21%), Positives = 126/342 (36%), Gaps = 57/342 (16%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLS-RPFQNVTHAKRAYREFKLMKLVNHKN 82 + +LR IG G+ G V A D + VAIKK+S Q+ + +E + ++ + H N Sbjct: 56 FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPN 115 Query: 83 IIGLLNAFTPQRNLEEFQDVYLVMELMDA---NLCQVIQMDLDHDRMSYLLYQMLCGIKH 139 I + + +LVME +L +V + L ++ + + L G+ + Sbjct: 116 TIQYRGCYLRE------HTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLAY 169 Query: 140 LHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVIL--- 196 LHS +IHRD+K NI++ +K+ DFG A +V T Y+ APEVIL Sbjct: 170 LHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAP---ANSFVGTPYWMAPEVILAMD 226 Query: 197 GMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRN 256 Y VD+WS+G E+ + + I + Sbjct: 227 EGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQ------------------- 267 Query: 257 YVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALK 316 S + RN + L P+ R + + LK Sbjct: 268 ----------------------NESPALQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLK 305 Query: 317 HEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYEE 358 H ++ + D + + K+++++E Sbjct: 306 HRFVLRERPPTVIMDLIQRTKDAVRELDNLQYRKMKKILFQE 347 >4B8L-A nrPDB Length = 286 Score = 225 bits (574), Expect = 2e-59, Method: Composition-based stats. Identities = 68/315 (21%), Positives = 123/315 (39%), Gaps = 55/315 (17%) Query: 11 VEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRP-FQNVTHAKRAY 69 E+ FTI + RP+G G G V A + + +A+K L + + + Sbjct: 5 AEMPKRKFTIDD-FDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLR 63 Query: 70 REFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQM--DLDHDRM 126 RE ++ + H NI+ + N F ++ +YL++E L + +Q D R Sbjct: 64 REIEIQSHLRHPNILRMYNYFHDRKR------IYLMLEFAPRGELYKELQKHGRFDEQRS 117 Query: 127 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVT 186 + + ++ + + H +IHRD+KP N+++ LKI DFG + A + T Sbjct: 118 ATFMEELADALHYCHERKVIHRDIKPENLLMGYKGELKIADFGWSVHAPS-LRRRTMCGT 176 Query: 187 RYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSF 246 Y PE+I G + E VD+W G + E + G F H + +I+ P Sbjct: 177 LDYLPPEMIEGKTHDEKVDLWCAGVLCYEFLVGMPPFDSPSHTETHRRIVNVDLKFPPFL 236 Query: 247 MQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPE 306 + +++L+SK+L P Sbjct: 237 -------------------------------------------SDGSKDLISKLLRYHPP 253 Query: 307 QRISVDEALKHEYIN 321 QR+ + ++H ++ Sbjct: 254 QRLPLKGVMEHPWVK 268 >5DYK-A nrPDB Length = 853 Score = 225 bits (574), Expect = 2e-59, Method: Composition-based stats. Identities = 81/328 (24%), Positives = 129/328 (39%), Gaps = 58/328 (17%) Query: 5 QHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKL-SRPFQNVT 63 H +++ DT + R IG G G V + T+ A+K + R N+ Sbjct: 523 AHLEERIKMQDTKVEMDE-LETERIIGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINLN 581 Query: 64 HAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN-LCQVIQMD-- 120 E ++ +H II L+ F + Y + EL+ L I+ Sbjct: 582 QQNNIKLEREITAENDHPFIIRLVRTFKDSKYF------YFLTELVTGGELYDAIRKLGL 635 Query: 121 LDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMM 180 L + + L ++ I++LH I++RDLKP NI++ +K++DFG A+ Sbjct: 636 LSKSQAQFYLGSIILAIEYLHERNIVYRDLKPENILLDKQGYVKLIDFGCAKKV--QGRA 693 Query: 181 TPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLG 240 V T +Y APEVILG GY VDIW++G + E I G + F G D DQ I + Sbjct: 694 YTLVGTPHYMAPEVILGKGYGCTVDIWALGICLYEFICGPLPF-GNDEEDQLE-IFRDIL 751 Query: 241 TPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKM 300 T FPD + +D+ NL+ ++ Sbjct: 752 TG---------------------------QLTFPDYV-----------TDTDSINLMKRL 773 Query: 301 LVIDPEQRISV-----DEALKHEYINVW 323 L P+ RI + H + + + Sbjct: 774 LCRLPQGRIGCSINGFKDIKDHPFFSNF 801 >3EQC-A nrPDB Length = 360 Score = 225 bits (573), Expect = 3e-59, Method: Composition-based stats. Identities = 75/328 (22%), Positives = 143/328 (43%), Gaps = 23/328 (7%) Query: 11 VEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYR 70 +VG+ + + +G+G G+V + +A K + + + R Sbjct: 25 QKVGELK---DDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIK-PAIRNQIIR 80 Query: 71 EFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN-LCQVIQM--DLDHDRMS 127 E +++ N I+G AF ++ + ME MD L QV++ + + Sbjct: 81 ELQVLHECNSPYIVGFYGAFYSDG------EISICMEHMDGGSLDQVLKKAGRIPEQILG 134 Query: 128 YLLYQMLCGIKHL-HSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVT 186 + ++ G+ +L I+HRD+KPSNI+V + +K+ DFG++ + M +V T Sbjct: 135 KVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS-MANSFVGT 193 Query: 187 RYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHID---QWNKIIEQLGTPS 243 R Y +PE + G Y+ DIWS+G + EM G P D + + +E + Sbjct: 194 RSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAET 253 Query: 244 PSFMQRLQPTVRNY-VENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLV 302 P + + + +++RP + + P S + + ++ ++K L+ Sbjct: 254 PPRPRTPGRPLNKFGMDSRPPMAIFELLDYIVNEPPP---KLPSGVFSLEFQDFVNKCLI 310 Query: 303 IDPEQRISVDEALKHEYINVWYDAEEVD 330 +P +R + + + H +I DAEEVD Sbjct: 311 KNPAERADLKQLMVHAFIK-RSDAEEVD 337 >1NY3-A nrPDB Length = 400 Score = 224 bits (572), Expect = 3e-59, Method: Composition-based stats. Identities = 73/352 (20%), Positives = 138/352 (39%), Gaps = 60/352 (17%) Query: 15 DTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKL 74 N I + + +G G G V ++ TQ+ A+K L +A RE +L Sbjct: 55 KKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-------QDCPKARREVEL 107 Query: 75 M-KLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN-----LCQVIQMDLDHDRMSY 128 + +I+ +++ + + + + +VME +D + S Sbjct: 108 HWRASQCPHIVRIVDVY--ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASE 165 Query: 129 LLYQMLCGIKHLHSAGIIHRDLKPSNIVVKA---DCTLKILDFGLARTAGTTFMMTPYVV 185 ++ + I++LHS I HRD+KP N++ + + LK+ DFG A+ + +T Sbjct: 166 IMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCY 225 Query: 186 TRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPS 245 T YY APEV+ Y ++ D+WS+G IM ++ G F + Sbjct: 226 TPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGL---------------- 269 Query: 246 FMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDP 305 + ++ R R Y F N + + + L+ +L +P Sbjct: 270 -------AISPGMKTRIRMGQYEFP------------NPEWSEVSEEVKMLIRNLLKTEP 310 Query: 306 EQRISVDEALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYE 357 QR+++ E + H +I P+ H+ + E+W+++ E Sbjct: 311 TQRMTITEFMNHPWIMQ-------STKVPQTPLHTSRVLKEDKERWEDVKEE 355 >4J52-A nrPDB Length = 293 Score = 224 bits (572), Expect = 4e-59, Method: Composition-based stats. Identities = 66/309 (21%), Positives = 114/309 (36%), Gaps = 54/309 (17%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQ-NVTHAKRAYREFKLMKLVNHKNIIGLLN 88 +G G D T++ A K + + ++ E + + + H++++G Sbjct: 22 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 81 Query: 89 AFTPQRNLEEFQDVYLVMELMDANLCQVIQMD---LDHDRMSYLLYQMLCGIKHLHSAGI 145 F V++V+EL + L Y L Q++ G ++LH + Sbjct: 82 FFEDNDF------VFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRV 135 Query: 146 IHRDLKPSNIVVKADCTLKILDFGLA-RTAGTTFMMTPYVVTRYYRAPEVILGMGYTENV 204 IHRDLK N+ + D +KI DFGLA + T Y APEV+ G++ V Sbjct: 136 IHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGHSFEV 195 Query: 205 DIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENRPRY 264 D+WS+GCIM ++ G F + + + +I + Sbjct: 196 DVWSIGCIMYTLLVGKPPFETSCLKETYLRIKK--------------------------- 228 Query: 265 TGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEYINVWY 324 + + A +L+ KML DP R +++E L E+ Y Sbjct: 229 ----------------NEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGY 272 Query: 325 DAEEVDAPA 333 + Sbjct: 273 IPARLPITC 281 >6QAU-A nrPDB Length = 280 Score = 224 bits (571), Expect = 4e-59, Method: Composition-based stats. Identities = 74/278 (26%), Positives = 117/278 (42%), Gaps = 24/278 (8%) Query: 14 GDTNFTIHSRYINLRPIGSGAQGIVCAAYDT-ITQQNVAIKKLSRPFQNVTHAKRAYREF 72 G Y +G GA +V T VAIK +++ + + +E Sbjct: 3 GSMEVVGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQI-LLGKEI 61 Query: 73 KLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDA-NLCQVIQMD--LDHDRMSYL 129 K++K + H+NI+ L + E V+LVME + +L +Q L D + Sbjct: 62 KILKELQHENIVALYDV------QELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVF 115 Query: 130 LYQMLCGIKHLHSAGIIHRDLKPSNIVVK---------ADCTLKILDFGLARTAGTTFMM 180 L+Q+ ++ LHS GIIHRDLKP NI++ + +KI DFG AR + M Sbjct: 116 LHQIAAAMRILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMA 175 Query: 181 TPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLG 240 + Y APEVI+ Y D+WS+G ++ + + G F D E+ Sbjct: 176 ADLCGSPMYMAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQD-LRMFYEKNR 234 Query: 241 TPSPSFMQRLQPTVRNYVEN---RPRYTGYSFDRLFPD 275 + PS + P + N + R + F+ F Sbjct: 235 SLMPSIPRETSPYLANLLLGLLQRNQKDRMDFEAFFSH 272 >3KA0-A nrPDB Length = 320 Score = 224 bits (571), Expect = 5e-59, Method: Composition-based stats. Identities = 73/352 (20%), Positives = 138/352 (39%), Gaps = 60/352 (17%) Query: 15 DTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKL 74 N I + + +G G G V ++ TQ+ A+K L +A RE +L Sbjct: 9 KKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-------QDCPKARREVEL 61 Query: 75 M-KLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN-----LCQVIQMDLDHDRMSY 128 + +I+ +++ + + + + +VME +D + S Sbjct: 62 HWRASQCPHIVRIVDVY--ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASE 119 Query: 129 LLYQMLCGIKHLHSAGIIHRDLKPSNIVVKA---DCTLKILDFGLARTAGTTFMMTPYVV 185 ++ + I++LHS I HRD+KP N++ + + LK+ DFG A+ + +T Sbjct: 120 IMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTEPCY 179 Query: 186 TRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPS 245 T YY APEV+ Y ++ D+WS+G IM ++ G F + Sbjct: 180 TPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGL---------------- 223 Query: 246 FMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDP 305 + ++ R R Y F N + + + L+ +L +P Sbjct: 224 -------AISPGMKTRIRMGQYEFP------------NPEWSEVSEEVKMLIRNLLKTEP 264 Query: 306 EQRISVDEALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYE 357 QR+++ E + H +I P+ H+ + E+W+++ E Sbjct: 265 TQRMTITEFMNHPWIMQ-------STKVPQTPLHTSRVLKEDKERWEDVKEE 309 >5J5T-A nrPDB Length = 370 Score = 224 bits (570), Expect = 6e-59, Method: Composition-based stats. Identities = 67/361 (18%), Positives = 132/361 (36%), Gaps = 60/361 (16%) Query: 21 HSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNH 80 + ++ IGSG G V A + T + AIK + + +E +MK H Sbjct: 3 QEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIK--LEPGEDFAVVQQEIIMMKDCKH 60 Query: 81 KNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQ---MDLDHDRMSYLLYQMLCGI 137 NI+ ++ + L ++ ME Q I L +++Y+ + L G+ Sbjct: 61 PNIVAYFGSYLRRDKL------WICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGL 114 Query: 138 KHLHSAGIIHRDLKPSNIVVKADCTLKILDFGL-ARTAGTTFMMTPYVVTRYYRAPEVI- 195 +LHS G +HRD+K +NI++ + +K+ DFG+ A+ T ++ T Y+ APEV Sbjct: 115 YYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKAFIGTPYWMAPEVAA 174 Query: 196 --LGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPT 253 GY + D+W+VG E+ + + + P Sbjct: 175 VERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPP---------- 224 Query: 254 VRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDE 313 ++ + ++ + + L +P++R + ++ Sbjct: 225 ----------------------------KLKDKMKWSNSFHHFVKMALTKNPKKRPTAEK 256 Query: 314 ALKHEYINVWYD-------AEEVDAPAPEPYDHSVDEREHTVEQWKELIYEEVMDYEAHN 366 L+H ++ ++V+ P Y D+ + I+ + Sbjct: 257 LLQHPFVTQHLTRSLAIELLDKVNNPDHSTYHDFDDDDPEPLVAVPHRIHSTSRNVREEK 316 Query: 367 T 367 T Sbjct: 317 T 317 >2GCD-A nrPDB Length = 309 Score = 224 bits (570), Expect = 7e-59, Method: Composition-based stats. Identities = 73/342 (21%), Positives = 126/342 (36%), Gaps = 57/342 (16%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLS-RPFQNVTHAKRAYREFKLMKLVNHKN 82 + +LR IG G+ G V A D + VAIKK+S Q+ + +E + ++ + H N Sbjct: 17 FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPN 76 Query: 83 IIGLLNAFTPQRNLEEFQDVYLVMELMDA---NLCQVIQMDLDHDRMSYLLYQMLCGIKH 139 I + + +LVME +L +V + L ++ + + L G+ + Sbjct: 77 TIQYRGCYLRE------HTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLAY 130 Query: 140 LHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVIL--- 196 LHS +IHRD+K NI++ +K+ DFG A +V T Y+ APEVIL Sbjct: 131 LHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAP---ANSFVGTPYWMAPEVILAMD 187 Query: 197 GMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRN 256 Y VD+WS+G E+ + + I + Sbjct: 188 EGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQ------------------- 228 Query: 257 YVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALK 316 S + RN + L P+ R + + LK Sbjct: 229 ----------------------NESPALQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLK 266 Query: 317 HEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYEE 358 H ++ + D + + K+++++E Sbjct: 267 HRFVLRERPPTVIMDLIQRTKDAVRELDNLQYRKMKKILFQE 308 >2OZA-A nrPDB Length = 356 Score = 223 bits (569), Expect = 8e-59, Method: Composition-based stats. Identities = 73/352 (20%), Positives = 138/352 (39%), Gaps = 60/352 (17%) Query: 15 DTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKL 74 N I + + +G G G V ++ TQ+ A+K L +A RE +L Sbjct: 11 KKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-------QDCPKARREVEL 63 Query: 75 M-KLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN-----LCQVIQMDLDHDRMSY 128 + +I+ +++ + + + + +VME +D + S Sbjct: 64 HWRASQCPHIVRIVDVY--ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASE 121 Query: 129 LLYQMLCGIKHLHSAGIIHRDLKPSNIVVKA---DCTLKILDFGLARTAGTTFMMTPYVV 185 ++ + I++LHS I HRD+KP N++ + + LK+ DFG A+ + +T Sbjct: 122 IMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCY 181 Query: 186 TRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPS 245 T YY APEV+ Y ++ D+WS+G IM ++ G F + Sbjct: 182 TPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGL---------------- 225 Query: 246 FMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDP 305 + ++ R R Y F N + + + L+ +L +P Sbjct: 226 -------AISPGMKTRIRMGQYEFP------------NPEWSEVSEEVKMLIRNLLKTEP 266 Query: 306 EQRISVDEALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYE 357 QR+++ E + H +I P+ H+ + E+W+++ E Sbjct: 267 TQRMTITEFMNHPWIMQ-------STKVPQTPLHTSRVLKEDKERWEDVKEE 311 >1VZO-A nrPDB Length = 355 Score = 223 bits (568), Expect = 1e-58, Method: Composition-based stats. Identities = 73/354 (20%), Positives = 145/354 (40%), Gaps = 71/354 (20%) Query: 1 MTTAQHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDT---ITQQNVAIKKLSR 57 + TA + +VG NF + L+ +G+GA G V T + A+K L + Sbjct: 39 LRTANLTGHAEKVGIENFEL------LKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKK 92 Query: 58 P--FQNVTHAKRAYREFKLMKLVN-HKNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN-L 113 Q + E ++++ + ++ L AF + L L+++ ++ L Sbjct: 93 ATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLH------LILDYINGGEL 146 Query: 114 CQVI--QMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLA 171 + + + + +++ ++HLH GII+RD+K NI++ ++ + + DFGL+ Sbjct: 147 FTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLS 206 Query: 172 RT--AGTTFMMTPYVVTRYYRAPEVILG--MGYTENVDIWSVGCIMGEMIRGGVLFPGTD 227 + A T + T Y AP+++ G G+ + VD WS+G +M E++ G F Sbjct: 207 KEFVADETERAYDFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDG 266 Query: 228 HIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSR 287 + +I ++ P + Q + Sbjct: 267 EKNSQAEISRRILKSEPPYPQEM------------------------------------- 289 Query: 288 RKASDARNLLSKMLVIDPEQRI-----SVDEALKHEYINV--WYDAEEVDAPAP 334 ++ A++L+ ++L+ DP++R+ DE +H + W D PAP Sbjct: 290 --SALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAP 341 >5FET-A nrPDB Length = 847 Score = 222 bits (567), Expect = 1e-58, Method: Composition-based stats. Identities = 80/325 (24%), Positives = 126/325 (38%), Gaps = 58/325 (17%) Query: 5 QHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKL-SRPFQNVT 63 H +++ DT +H R IG G G V + TQ A+K + R ++ Sbjct: 517 THLEERIKMQDTKVEMHE-LETERIIGRGTFGTVKLVHHKPTQIRYALKCVSKRSIISLN 575 Query: 64 HAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN-LCQVIQMD-- 120 E ++ +H II L+ F Y + EL+ L I+ Sbjct: 576 QQNNIKLEREITAENDHPFIIRLVRTFKDSNCF------YFLTELVTGGELYDAIRKLGL 629 Query: 121 LDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMM 180 L + + L ++ I++LH I++RDLKP NI++ +K++DFG A+ Sbjct: 630 LSKPQAQFYLGSIILAIEYLHERNIVYRDLKPENILLDKQGYVKLIDFGCAKKI--QGRA 687 Query: 181 TPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLG 240 V T +Y APEVILG GY VDIW++G + E I G + F G D DQ I + Sbjct: 688 YTLVGTPHYMAPEVILGKGYGCTVDIWALGVCLYEFICGPLPF-GNDQEDQLE-IFRDIL 745 Query: 241 TPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKM 300 T +F + D+ NL+ ++ Sbjct: 746 TGQLTFPDYVS--------------------------------------DQDSINLMKRL 767 Query: 301 LVIDPEQRISV-----DEALKHEYI 320 L P+ RI + +H + Sbjct: 768 LCRLPQGRIGCSINGFKDIKEHAFF 792 >4WNO-A nrPDB Length = 287 Score = 222 bits (566), Expect = 2e-58, Method: Composition-based stats. Identities = 74/282 (26%), Positives = 116/282 (41%), Gaps = 26/282 (9%) Query: 12 EVGDTNFTIHSRYINLRP--IGSGAQGIVCAAYDTITQQ-NVAIKKLSRPFQNVTHAKRA 68 E G ++ R IG GA +V VA+K +++ +N+ ++ Sbjct: 6 EPGRGGTETVGKFEFSRKDLIGHGAFAVVFKGRHRAAHDLEVAVKCINK--KNLAKSQTL 63 Query: 69 Y-REFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDA-NLCQVIQ--MDLDHD 124 +E K++K + H+NI+ L + E VYLVME + +L + L D Sbjct: 64 LGKEIKILKELKHENIVALYDF------QEMANSVYLVMEYCNGGDLADYLHAMRTLSED 117 Query: 125 RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADC---------TLKILDFGLARTAG 175 + L Q+ ++ LHS GIIHRDLKP NI++ +KI DFG AR Sbjct: 118 TIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQ 177 Query: 176 TTFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHID--QWN 233 + M + Y APEVI+ Y D+WS+G I+ + + G F + D + Sbjct: 178 SNMMAATLCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFY 237 Query: 234 KIIEQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPD 275 + + L P + + R FD F Sbjct: 238 EKNKTLVPTIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHH 279 >6CKI-A nrPDB Length = 316 Score = 222 bits (566), Expect = 2e-58, Method: Composition-based stats. Identities = 74/323 (22%), Positives = 127/323 (39%), Gaps = 53/323 (16%) Query: 20 IHSRYINLR-PIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLV 78 Y +G GA V + IT Q A+K + + ++ R +RE +++ Sbjct: 10 FEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHI--RSRVFREVEMLYQC 67 Query: 79 N-HKNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN--LCQVIQMD-LDHDRMSYLLYQML 134 H+N+ EE YLV E M L + + + S ++ + Sbjct: 68 QGHRNV------LELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVA 121 Query: 135 CGIKHLHSAGIIHRDLKPSNIVVKADCT---LKILDFGLARTAG--------TTFMMTPY 183 + LH+ GI HRDLKP NI+ + +KI DFGL +T + Sbjct: 122 SALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPELLTP 181 Query: 184 VVTRYYRAPEVILGMG-----YTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQ 238 + Y APEV+ Y + D+WS+G I+ ++ G F G + Sbjct: 182 CGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVG------------R 229 Query: 239 LGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLS 298 G+ P +N + + Y F +++ + A++L+S Sbjct: 230 CGSDCGWDRGEACPACQNMLFESIQEGKYEFP------------DKDWAHISCAAKDLIS 277 Query: 299 KMLVIDPEQRISVDEALKHEYIN 321 K+LV D +QR+S + L+H ++ Sbjct: 278 KLLVRDAKQRLSAAQVLQHPWVQ 300 >2XYN-A nrPDB Length = 292 Score = 222 bits (565), Expect = 2e-58, Method: Composition-based stats. Identities = 64/290 (22%), Positives = 117/290 (40%), Gaps = 33/290 (11%) Query: 11 VEVGDTNFTIHS--RYINLR-------PIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQN 61 V++G N S ++ R +G G G V VA+K L ++ Sbjct: 12 VDLGTENLYFQSMDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLK---ED 68 Query: 62 VTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQMD 120 + +E +MK + H N++ LL T + Y+V E M NL ++ Sbjct: 69 TMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPF------YIVTEYMPYGNLLDYLREC 122 Query: 121 LDHDR----MSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTA-- 174 + + Y+ Q+ +++L IHRDL N +V + +K+ DFGL+R Sbjct: 123 NREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTG 182 Query: 175 GTTFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQWN 233 T + APE + ++ D+W+ G ++ E+ G +PG D ++ Sbjct: 183 DTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYD 242 Query: 234 KI-----IEQLGTPSPSFMQRLQPTVRNYVENRPRY--TGYSFDRLFPDG 276 + +EQ P + ++ + +RP + T +F+ +F D Sbjct: 243 LLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDS 292 >3FXW-A nrPDB Length = 336 Score = 222 bits (565), Expect = 2e-58, Method: Composition-based stats. Identities = 78/355 (21%), Positives = 135/355 (38%), Gaps = 66/355 (18%) Query: 15 DTNFTIHSRYINLR-PIGSGAQGIVCAAYDTITQQNVAIKKL---SRPFQNVTHAKRAYR 70 + + Y + +G G G V + T Q A+K L + Q V H +A Sbjct: 21 PKKYAVTDDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLLYDSPKARQEVDHHWQA-- 78 Query: 71 EFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN-LCQVIQMD----LDHDR 125 +I+ +L+ + + + + ++ME M+ L IQ Sbjct: 79 -------SGGPHIVCILDVY--ENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTERE 129 Query: 126 MSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKA---DCTLKILDFGLARTAGTTFMMTP 182 + ++ + I+ LHS I HRD+KP N++ + D LK+ DFG A+ + TP Sbjct: 130 AAEIMRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNALQTP 189 Query: 183 YVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTP 242 T YY APEV+ Y ++ D+WS+G IM ++ G F Sbjct: 190 -CYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGFPPFYSNT--------------- 233 Query: 243 SPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLV 302 + ++ R R Y F N + DA+ L+ +L Sbjct: 234 --------GQAISPGMKRRIRLGQYGFP------------NPEWSEVSEDAKQLIRLLLK 273 Query: 303 IDPEQRISVDEALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYE 357 DP +R+++ + + H +IN P+ H+ + + W E+ E Sbjct: 274 TDPTERLTITQFMNHPWINQ-------SMVVPQTPLHTARVLQEDKDHWDEVKEE 321 >4AF3-A nrPDB Length = 292 Score = 222 bits (565), Expect = 2e-58, Method: Composition-based stats. Identities = 73/320 (22%), Positives = 135/320 (42%), Gaps = 55/320 (17%) Query: 5 QHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRP-FQNVT 63 ++ T ++ +FTI + RP+G G G V A + + VA+K L + + Sbjct: 7 ENSSGTPDILTRHFTIDD-FEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEG 65 Query: 64 HAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQMD-- 120 + RE ++ ++H NI+ L N F +R +YL++E L + +Q Sbjct: 66 VEHQLRREIEIQAHLHHPNILRLYNYFYDRRR------IYLILEYAPRGELYKELQKSCT 119 Query: 121 LDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMM 180 D R + ++ ++ + + H +IHRD+KP N+++ LKI DFG + A + Sbjct: 120 FDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPS-LRR 178 Query: 181 TPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLG 240 T Y PE+I G + E VD+W +G + E++ G F H + + +I++ Sbjct: 179 KTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKV-- 236 Query: 241 TPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKM 300 D FP + A++L+SK+ Sbjct: 237 -----------------------------DLKFPAS------------VPTGAQDLISKL 255 Query: 301 LVIDPEQRISVDEALKHEYI 320 L +P +R+ + + H ++ Sbjct: 256 LRHNPSERLPLAQVSAHPWV 275 >2X7G-A nrPDB Length = 389 Score = 222 bits (565), Expect = 3e-58, Method: Composition-based stats. Identities = 89/383 (23%), Positives = 144/383 (37%), Gaps = 77/383 (20%) Query: 5 QHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTH 64 + ++ V++GD + RY +R +G G V +D ++ VA+K + + Sbjct: 17 KGGYHPVKIGDL---FNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSA---QHY 70 Query: 65 AKRAYREFKLMKLVN-----HKN---IIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQV 116 + A E KL+K V N ++ L++ F V +V E++ +L + Sbjct: 71 TETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISG--MNGIHVCMVFEVLGHHLLKW 128 Query: 117 I----QMDLDHDRMSYLLYQMLCGIKHLHSA-GIIHRDLKPSNIVVKADC---------- 161 I L + ++ Q+L G+ +LHS IIH D+KP NI++ D Sbjct: 129 IIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEA 188 Query: 162 -------------------------------------TLKILDFGLARTAGTTFMMTPYV 184 +KI D G A F T + Sbjct: 189 TEWQKAGAPPPSGSAVSTAPAADLLVNPLDPRNADKIRVKIADLGNACWVHKHF--TEDI 246 Query: 185 VTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTD------HIDQWNKIIEQ 238 TR YR+ EV++G GY+ DIWS C+ E+ G LF D IIE Sbjct: 247 QTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIEL 306 Query: 239 LGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLS 298 LG+ P R + R + + + + A+ + L Sbjct: 307 LGS-IPRHFALSGKYSREFFNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLI 365 Query: 299 KMLVIDPEQRISVDEALKHEYIN 321 ML + PE+R S E L+H ++N Sbjct: 366 PMLEMVPEKRASAGECLRHPWLN 388 >2PVN-A nrPDB Length = 352 Score = 221 bits (562), Expect = 6e-58, Method: Composition-based stats. Identities = 78/329 (23%), Positives = 136/329 (41%), Gaps = 17/329 (5%) Query: 5 QHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTH 64 +++ E + Y +R +G G V + + K + + + V Sbjct: 35 PKEYWDYEALTVQWGEQDDYEVVRKVGRGKYSEVFEGINVNNNE----KCIIKILKPVKK 90 Query: 65 AKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHD 124 K L L NI+ LL+ Q + L+ E ++ +V+ L Sbjct: 91 KKIKREIKILQNLCGGPNIVKLLDIVRDQHSKTPS----LIFEYVNNTDFKVLYPTLTDY 146 Query: 125 RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCT-LKILDFGLARTAGTTFMMTPY 183 + Y +Y++L + + HS GI+HRD+KP N+++ + L+++D+GLA Sbjct: 147 DIRYYIYELLKALDYCHSQGIMHRDVKPHNVMIDHELRKLRLIDWGLAEFYHPGKEYNVR 206 Query: 184 VVTRYYRAPEVILG-MGYTENVDIWSVGCIMGEM-IRGGVLFPGTDHIDQWNKIIEQLGT 241 V +RY++ PE+++ Y ++D+WS+GC+ M R F G D+ DQ KI + LGT Sbjct: 207 VASRYFKGPELLVDLQDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKIAKVLGT 266 Query: 242 PSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKML 301 L + Y R N N + +A + L K+L Sbjct: 267 ------DGLNAYLNKYRIELDPQLEALVGRHSRKPWLKFMNADNQHLVSPEAIDFLDKLL 320 Query: 302 VIDPEQRISVDEALKHEYINVWYDAEEVD 330 D ++R++ EA+ H Y AE Sbjct: 321 RYDHQERLTALEAMTHPYFQQVRAAENSR 349 >3NYO-A nrPDB Length = 576 Score = 220 bits (561), Expect = 8e-58, Method: Composition-based stats. Identities = 78/311 (25%), Positives = 128/311 (41%), Gaps = 56/311 (18%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKR-AYREFKLMKLVNHKN 82 + R +G G G VCA T + A KKL + + A E ++++ VN + Sbjct: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRF 245 Query: 83 IIGLLNAFTPQRNLEEFQDVYLVMELMDAN-----LCQVIQMDLDHDRMSYLLYQMLCGI 137 ++ L A+ + L LV+ LM+ + + Q R + ++ CG+ Sbjct: 246 VVSLAYAYETKDAL------CLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGL 299 Query: 138 KHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILG 197 + LH I++RDLKP NI++ ++I D GLA + V T Y APEV+ Sbjct: 300 EDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKN 359 Query: 198 MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNY 257 YT + D W++GC++ EMI G F Q K I++ + ++ V+ Sbjct: 360 ERYTFSPDWWALGCLLYEMIAGQSPFQ------QRKKKIKR---------EEVERLVKEV 404 Query: 258 VENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRI-----SVD 312 E + S R + AR+L S++L DP +R+ S Sbjct: 405 PE------------------------EYSERFSPQARSLCSQLLCKDPAERLGCRGGSAR 440 Query: 313 EALKHEYINVW 323 E +H Sbjct: 441 EVKEHPLFKKL 451 >6ED6-A nrPDB Length = 415 Score = 220 bits (560), Expect = 9e-58, Method: Composition-based stats. Identities = 77/342 (22%), Positives = 124/342 (36%), Gaps = 62/342 (18%) Query: 22 SRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSR-PFQNVTHAKRAYREFKLMKLVNH 80 Y ++ IG GA G V +Q+ A+K LS+ + + + E +M N Sbjct: 88 EDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANS 147 Query: 81 KNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQ--MDLDHDRMSYLLYQMLCGIK 138 ++ L AF R L Y+VME M + D+ + +++ + Sbjct: 148 PWVVQLFYAFQDDRYL------YMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALD 201 Query: 139 HLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMM--TPYVVTRYYRAPEVIL 196 +HS G+IHRD+KP N+++ LK+ DFG T M+ V T Y +PEV+ Sbjct: 202 AIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLK 261 Query: 197 GMG----YTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQP 252 G Y D WSVG + EM+ G F + ++KI++ + Sbjct: 262 SQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLC--------- 312 Query: 253 TVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRI--- 309 + A+NL+ L D E R+ Sbjct: 313 ------------------------------FPEDAEISKHAKNLICAFLT-DREVRLGRN 341 Query: 310 SVDEALKHEYIN----VWYDAEEVDAPAPEPYDHSVDEREHT 347 V+E +H + W + E AP +D Sbjct: 342 GVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDIDSSNFD 383 >3ORZ-A nrPDB Length = 316 Score = 219 bits (559), Expect = 1e-57, Method: Composition-based stats. Identities = 70/326 (21%), Positives = 125/326 (38%), Gaps = 64/326 (19%) Query: 22 SRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQ-NVTHAKRAYREFKLMKLVNH 80 + + +G G+ V A + T + AIK L + RE +M ++H Sbjct: 37 EDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDH 96 Query: 81 KNIIGLLNAFTPQRNLEEFQDVYLVMELM-DANLCQVIQM--DLDHDRMSYLLYQMLCGI 137 + L F L Y + + L + I+ D + +++ + Sbjct: 97 PFFVKLYFCFQDDEKL------YFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSAL 150 Query: 138 KHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMM---TPYVVTRYYRAPEV 194 ++LH GIIHRDLKP NI++ D ++I DFG A+ +V T Y +PE+ Sbjct: 151 EYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPEL 210 Query: 195 ILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTV 254 + ++ D+W++GCI+ +++ G F + + KII+ Sbjct: 211 LTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIK----------------- 253 Query: 255 RNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDE- 313 + FP+ FP AR+L+ K+LV+D +R+ +E Sbjct: 254 --------------LEYDFPEKFFP------------KARDLVEKLLVLDATKRLGCEEM 287 Query: 314 -----ALKHEYIN--VWYDAEEVDAP 332 H + W + + P Sbjct: 288 EGYGPLKAHPFFESVTWENLHQQTPP 313 >5LOH-A nrPDB Length = 341 Score = 219 bits (558), Expect = 2e-57, Method: Composition-based stats. Identities = 69/339 (20%), Positives = 120/339 (35%), Gaps = 61/339 (17%) Query: 22 SRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRP-FQNVTHAKRAYREFKLMKLVNH 80 + ++PI GA G V + A+K + + N + E + L Sbjct: 36 EEFSIVKPISRGAFGKVYLGQKG--GKLYAVKVVKKADMINKNMTHQVQAERDALALSKS 93 Query: 81 KNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN---LCQVIQMDLDHDRMSYLLYQMLCGI 137 I+ L + L+ +VYLVME + I D + + ++ + Sbjct: 94 PFIVHLYYS------LQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALAL 147 Query: 138 KHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLAR-------TAGTTFMMTPYVVTRYYR 190 +LH GIIHRDLKP N+++ + +K+ DFGL++ + T Y Sbjct: 148 DYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILTTRTFCGTPDYL 207 Query: 191 APEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRL 250 APE++LG + VD W++G + E + G F + I+++ P P ++L Sbjct: 208 APELLLGRAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILKR-DIPWPEGEEKL 266 Query: 251 QPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRIS 310 ++ VE +L ID +R Sbjct: 267 SDNAQSAVEI---------------------------------------LLTIDDTKRAG 287 Query: 311 VDEALKHEYIN--VWYDAEEVDAPAPEPYDHSVDEREHT 347 + E +H + W + + P D D Sbjct: 288 MKELKRHPLFSDVDWENLQHQTMPFIPQPDDETDTSYFE 326 >6E9W-A nrPDB Length = 443 Score = 219 bits (557), Expect = 2e-57, Method: Composition-based stats. Identities = 62/246 (25%), Positives = 102/246 (41%), Gaps = 15/246 (6%) Query: 22 SRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSR-PFQNVTHAKRAYREFKLMKLVNH 80 Y ++ IG GA G V T++ A+K LS+ + + + E +M N Sbjct: 102 EDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANS 161 Query: 81 KNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQ--MDLDHDRMSYLLYQMLCGIK 138 ++ L AF R L Y+VME M + D+ + +++ + Sbjct: 162 PWVVQLFYAFQDDRYL------YMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALD 215 Query: 139 HLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMM--TPYVVTRYYRAPEVIL 196 +HS G IHRD+KP N+++ LK+ DFG M+ V T Y +PEV+ Sbjct: 216 AIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLK 275 Query: 197 GMG----YTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQP 252 G Y D WSVG + EM+ G F + ++KI+ + + + Sbjct: 276 SQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISK 335 Query: 253 TVRNYV 258 +N + Sbjct: 336 EAKNLI 341 >5N23-A nrPDB Length = 352 Score = 219 bits (557), Expect = 2e-57, Method: Composition-based stats. Identities = 65/308 (21%), Positives = 120/308 (38%), Gaps = 59/308 (19%) Query: 22 SRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSR-PFQNVTHAKRAYREFKLMKLVNH 80 ++ +R +G+G+ G V T + A+K L + + + E ++ + VN Sbjct: 42 DQFERIRTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRIQQAVNF 101 Query: 81 KNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN-LCQVIQM--DLDHDRMSYLLYQMLCGI 137 ++ L +F NL Y+V+E + ++ + Q++ Sbjct: 102 PFLVKLEFSFKDNSNL------YMVLEYAPGGEMFSHLRRIGRFSEPHARFYAAQIVLTF 155 Query: 138 KHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILG 197 ++LHS +I+RDLKP N+++ +K+ DFG A+ T T Y APE+IL Sbjct: 156 EYLHSLDLIYRDLKPENLLIDQQGYIKVADFGFAKRVKGRTPWT-LCGTPEYLAPEIILS 214 Query: 198 MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNY 257 GY + VD W++G ++ EM G F I + KI+ Sbjct: 215 KGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIV--------------------- 253 Query: 258 VENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRI-----SVD 312 + + +SD ++LL +L +D +R V+ Sbjct: 254 ----------------------SGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVN 291 Query: 313 EALKHEYI 320 + H++ Sbjct: 292 DIKNHKWF 299 >5X3F-B nrPDB Length = 393 Score = 218 bits (556), Expect = 2e-57, Method: Composition-based stats. Identities = 62/308 (20%), Positives = 121/308 (39%), Gaps = 60/308 (19%) Query: 22 SRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSR-PFQNVTHAKRAYREFKLMKLVNH 80 ++ ++ +G+G+ G V + + A+K L + + + E ++++ VN Sbjct: 84 DQFDRIKTLGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 143 Query: 81 KNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN-LCQVIQM--DLDHDRMSYLLYQMLCGI 137 ++ L +F NL Y+VME + + ++ + Q++ Sbjct: 144 PFLVKLEFSFKDNSNL------YMVMEYVAGGEMFSHLRRIGRFSEPHARFYAAQIVLTF 197 Query: 138 KHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILG 197 ++LHS +I+RDLKP N+++ +++ DFG A+ T Y APE+IL Sbjct: 198 EYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK--GRTWTLCGTPEYLAPEIILS 255 Query: 198 MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNY 257 GY + VD W++G ++ EM G F I + KI+ Sbjct: 256 KGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIV--------------------- 294 Query: 258 VENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRI-----SVD 312 + + +SD ++LL +L +D +R V+ Sbjct: 295 ----------------------SGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVN 332 Query: 313 EALKHEYI 320 + H++ Sbjct: 333 DIKNHKWF 340 >5YV8-A nrPDB Length = 298 Score = 218 bits (555), Expect = 3e-57, Method: Composition-based stats. Identities = 74/329 (22%), Positives = 130/329 (39%), Gaps = 75/329 (22%) Query: 23 RYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRP------------------------ 58 +Y IG G+ G+V AY+ A+K LS+ Sbjct: 14 QYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGC 73 Query: 59 FQNVTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQ 118 Q ++ Y+E ++K ++H N++ L+ +Y+V EL++ + Sbjct: 74 IQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNE----DHLYMVFELVNQGPVMEVP 129 Query: 119 --MDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTA-G 175 L D+ + ++ GI++LH IIHRD+KPSN++V D +KI DFG++ G Sbjct: 130 TLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKG 189 Query: 176 TTFMMTPYVVTRYYRAPEVILGMG---YTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQW 232 + +++ V T + APE + + +D+W++G + + G F + Sbjct: 190 SDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLH 249 Query: 233 NKIIEQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASD 292 +KI S FPD A D Sbjct: 250 SKI-------------------------------KSQALEFPD----------QPDIAED 268 Query: 293 ARNLLSKMLVIDPEQRISVDEALKHEYIN 321 ++L+++ML +PE RI V E H ++ Sbjct: 269 LKDLITRMLDKNPESRIVVPEIKLHPWVT 297 >4RA4-A nrPDB Length = 355 Score = 218 bits (555), Expect = 3e-57, Method: Composition-based stats. Identities = 68/344 (19%), Positives = 127/344 (36%), Gaps = 70/344 (20%) Query: 4 AQHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQ-NV 62 + V++ D NF + +G G+ G V A T++ AIK L + Sbjct: 10 PSNNLDRVKLTDFNFLM--------VLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQD 61 Query: 63 THAKRAYREFKLMKLVNHK-NIIGLLNAFTPQRNLEEFQDVYLVMELMDA-NLCQVIQM- 119 + E +++ L++ + L + F +Y VME ++ +L IQ Sbjct: 62 DDVECTMVEKRVLALLDKPPFLTQLHSCFQT------VDRLYFVMEYVNGGDLMYHIQQV 115 Query: 120 -DLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLART-AGTT 177 + + ++ G+ LH GII+RDLK N+++ ++ +KI DFG+ + Sbjct: 116 GKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDG 175 Query: 178 FMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIE 237 + T Y APE+I Y ++VD W+ G ++ EM+ G F G D + + I+E Sbjct: 176 VTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIME 235 Query: 238 QLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLL 297 N + + +A ++ Sbjct: 236 H-------------------------------------------NVSYPKSLSKEAVSIC 252 Query: 298 SKMLVIDPEQRISV-----DEALKHEYIN--VWYDAEEVDAPAP 334 ++ P +R+ + +H + W E + P Sbjct: 253 KGLMTKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPP 296 >4U41-A nrPDB Length = 332 Score = 217 bits (554), Expect = 5e-57, Method: Composition-based stats. Identities = 74/347 (21%), Positives = 121/347 (34%), Gaps = 56/347 (16%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKL-VNHKN 82 + + +G+G G V T Q AIK + K E ++K +H+N Sbjct: 26 FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKL---EINMLKKYSHHRN 82 Query: 83 IIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMD-----LDHDRMSYLLYQMLCGI 137 I AF + ++LVME A + + L D ++Y+ ++L G+ Sbjct: 83 IATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGL 142 Query: 138 KHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTF-MMTPYVVTRYYRAPEVIL 196 HLH +IHRD+K N+++ + +K++DFG++ T ++ T Y+ APEVI Sbjct: 143 AHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIA 202 Query: 197 -----GMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQ 251 Y D+WS G EM G + I P P + Sbjct: 203 CDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPR---NPPPRLKSKKW 259 Query: 252 PTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISV 311 + LV + QR S Sbjct: 260 SKKFFSF--------------------------------------IEGCLVKNYMQRPST 281 Query: 312 DEALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYEE 358 ++ LKH +I + +V + D + +R E E E Sbjct: 282 EQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSE 328 >3PPZ-A nrPDB Length = 309 Score = 217 bits (553), Expect = 6e-57, Method: Composition-based stats. Identities = 71/300 (23%), Positives = 123/300 (41%), Gaps = 25/300 (8%) Query: 3 TAQHQHYTVEVGDTNFTIHSRYINLR-PIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQN 61 T ++ ++ + + I +N++ IG+G+ G V A +VA+K L + Sbjct: 17 TTENLYFQGAMDGDDMDIPWCDLNIKEKIGAGSFGTVHRAEWH--GSDVAVKILMEQDFH 74 Query: 62 VTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQM- 119 RE +MK + H NI+ + A T NL +V E + +L +++ Sbjct: 75 AERVNEFLREVAIMKRLRHPNIVLFMGAVTQPPNLS------IVTEYLSRGSLYRLLHKS 128 Query: 120 ----DLDHDRMSYLLYQMLCGIKHLHSAG--IIHRDLKPSNIVVKADCTLKILDFGLART 173 LD R + Y + G+ +LH+ I+HRDLK N++V T+K+ DFGL+R Sbjct: 129 GAREQLDERRRLSMAYDVAKGMNYLHNRNPPIVHRDLKSPNLLVDKKYTVKVCDFGLSRL 188 Query: 174 AGTTFMM-TPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQW 232 +TF+ T + APEV+ E D++S G I+ E+ + + Sbjct: 189 KASTFLSSKSAAGTPEWMAPEVLRDEPSNEKSDVYSFGVILWELATLQQPWGNLNPAQVV 248 Query: 233 NKI------IEQLGTPSPSFMQRLQPTVRNYVENRPRY-TGYSFDRLFPDGLFPNDNNQN 285 + +E +P ++ N RP + T R P N + Sbjct: 249 AAVGFKCKRLEIPRNLNPQVAAIIEGCWTNEPWKRPSFATIMDLLRPLIKSAVPPPNRSD 308 >6CQF-A nrPDB Length = 297 Score = 217 bits (552), Expect = 8e-57, Method: Composition-based stats. Identities = 66/304 (21%), Positives = 114/304 (37%), Gaps = 53/304 (17%) Query: 21 HSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNH 80 Y L+ +G G G V A D ++ VA+K + + +E ++K H Sbjct: 15 RDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVK--MEPDDDVSTLQKEILILKTCRH 72 Query: 81 KNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQM---DLDHDRMSYLLYQMLCGI 137 NI+ ++ Q +++ ME A Q I L ++SY+ ++L G+ Sbjct: 73 ANIVAYHGSYL------WLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGL 126 Query: 138 KHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMT-PYVVTRYYRAPE--- 193 +LHS IHRD+K +NI++ +++ DFG++ G T ++ T Y+ APE Sbjct: 127 AYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLAFIGTPYWMAPEVAA 186 Query: 194 VILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPT 253 V L GY E DIWS+G E+ + + + P Sbjct: 187 VALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPR--------- 237 Query: 254 VRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDE 313 + + ++ N + L P++R S + Sbjct: 238 -----------------------------LKEKGKWSAAFHNFIKVTLTKSPKKRPSATK 268 Query: 314 ALKH 317 L H Sbjct: 269 MLSH 272 >4WB7-A nrPDB Length = 405 Score = 216 bits (551), Expect = 1e-56, Method: Composition-based stats. Identities = 63/308 (20%), Positives = 121/308 (39%), Gaps = 60/308 (19%) Query: 22 SRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSR-PFQNVTHAKRAYREFKLMKLVNH 80 ++ ++ +G+G+ G V T + A+K L + + + E ++++ VN Sbjct: 96 DQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 155 Query: 81 KNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN-LCQVIQM--DLDHDRMSYLLYQMLCGI 137 ++ L +F NL Y+VME + + ++ + Q++ Sbjct: 156 PFLVKLEFSFKDNSNL------YMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTF 209 Query: 138 KHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILG 197 ++LHS +I+RDLKP N+++ +++ DFG A+ T Y APE+IL Sbjct: 210 EYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK--GRTWTLCGTPEYLAPEIILS 267 Query: 198 MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNY 257 GY + VD W++G ++ EM G F I + KI+ Sbjct: 268 KGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIV--------------------- 306 Query: 258 VENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRI-----SVD 312 + + +SD ++LL +L +D +R V+ Sbjct: 307 ----------------------SGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVN 344 Query: 313 EALKHEYI 320 + H++ Sbjct: 345 DIKNHKWF 352 >3RAW-A nrPDB Length = 381 Score = 216 bits (551), Expect = 1e-56, Method: Composition-based stats. Identities = 79/351 (22%), Positives = 140/351 (39%), Gaps = 36/351 (10%) Query: 4 AQHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQ-NVAIKKLSRPFQNV 62 + H +GD + RY + +G G G V D + VA+K + + Sbjct: 36 DKEGHLVCRIGDW---LQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGK-- 90 Query: 63 THAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQ---- 118 + + A E ++K + K+ + + EL+ N + ++ Sbjct: 91 -YREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNF 149 Query: 119 MDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKA------------------- 159 + ++ YQ+ ++ LH + H DLKP NI+ Sbjct: 150 QPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVK 209 Query: 160 DCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRG 219 + ++++ DFG A T V TR+YR PEVIL +G+ + D+WS+GCI+ E RG Sbjct: 210 NTSIRVADFGSATFDHEHH--TTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRG 267 Query: 220 GVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFP 279 LF ++ + ++E++ P PS M + + + + S D + Sbjct: 268 FTLFQTHENREHLV-MMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCK 326 Query: 280 NDNNQNSRRKAS--DARNLLSKMLVIDPEQRISVDEALKHEYINVWYDAEE 328 + + +L+ +ML DP QRI++ EAL H + EE Sbjct: 327 PLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFF-AGLTPEE 376 >4EBW-A nrPDB Length = 304 Score = 216 bits (551), Expect = 1e-56, Method: Composition-based stats. Identities = 64/282 (22%), Positives = 112/282 (39%), Gaps = 26/282 (9%) Query: 3 TAQHQHYTVEVGDT--NFTIH-SRYINLRPIGSGAQGIVCAAYDTITQQN---VAIKKLS 56 T ++ ++ +G + ++ I R R IG G G V + VAIK Sbjct: 16 TTENLYFQGAMGSSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCK 75 Query: 57 RPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMD----AN 112 + + ++ +E M+ +H +I+ L+ T V+++MEL + Sbjct: 76 NCTSD-SVREKFLQEALTMRQFDHPHIVKLIGVITEN-------PVWIIMELCTLGELRS 127 Query: 113 LCQVIQMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLAR 172 QV + LD + YQ+ + +L S +HRD+ N++V ++ +K+ DFGL+R Sbjct: 128 FLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSR 187 Query: 173 TAGTTFMMTPYVV--TRYYRAPEVILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGTDHI 229 + + APE I +T D+W G M E++ G F G + Sbjct: 188 YMEDSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNN 247 Query: 230 DQWNKIIEQLGTP-----SPSFMQRLQPTVRNYVENRPRYTG 266 D +I P P+ + RPR+T Sbjct: 248 DVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTE 289 >3ALO-A nrPDB Length = 327 Score = 216 bits (549), Expect = 2e-56, Method: Composition-based stats. Identities = 66/314 (21%), Positives = 114/314 (36%), Gaps = 57/314 (18%) Query: 25 INLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNII 84 +L IG GA G V + Q +A+K++ + +M+ + I+ Sbjct: 25 KDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIV 84 Query: 85 GLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMD-------LDHDRMSYLLYQMLCGI 137 A L D ++ MELM + + + + + + + + + Sbjct: 85 QFYGA------LFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKAL 138 Query: 138 KHLHSA-GIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVI- 195 HL IIHRD+KPSNI++ +K+ DFG++ + T R Y APE I Sbjct: 139 NHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERID 198 Query: 196 ---LGMGYTENVDIWSVGCIMGEMIRGGVLFPG-TDHIDQWNKIIEQLGTPSPSFMQRLQ 251 GY D+WS+G + E+ G +P DQ ++++ Sbjct: 199 PSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVK-------------- 244 Query: 252 PTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISV 311 G P +N R + N ++ L D +R Sbjct: 245 ------------------------GDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKY 280 Query: 312 DEALKHEYINVWYD 325 E LKH +I ++ + Sbjct: 281 KELLKHPFILMYEE 294 >3VN9-A nrPDB Length = 340 Score = 215 bits (548), Expect = 2e-56, Method: Composition-based stats. Identities = 71/334 (21%), Positives = 137/334 (41%), Gaps = 61/334 (18%) Query: 11 VEVGDTNFTIH-SRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAY 69 + +G+ NF + + +G GA G+V + Q +A+K++ R N KR Sbjct: 39 ISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI-RATVNSQEQKRLL 97 Query: 70 REFKL-MKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQM------DLD 122 + + M+ V+ + A L DV++ MELMD +L + + + Sbjct: 98 MDLDISMRTVDCPFTVTFYGA------LFREGDVWICMELMDTSLDKFYKQVIDKGQTIP 151 Query: 123 HDRMSYLLYQMLCGIKHLHSA-GIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMT 181 D + + ++ ++HLHS +IHRD+KPSN+++ A +K+ DFG++ + T Sbjct: 152 EDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKT 211 Query: 182 PYVVTRYYRAPEVI----LGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIE 237 + Y APE I GY+ DIWS+G M E+ + FP + ++ + Sbjct: 212 IDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAI--LRFPYDSWGTPFQQLKQ 269 Query: 238 QLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLL 297 + PSP + +++ + Sbjct: 270 VVEEPSPQLPAD--------------------------------------KFSAEFVDFT 291 Query: 298 SKMLVIDPEQRISVDEALKHEYINVWYDAEEVDA 331 S+ L + ++R + E ++H + ++++ D Sbjct: 292 SQCLKKNSKERPTYPELMQHPFFT-LHESKGTDV 324 >4CRL-A nrPDB Length = 406 Score = 215 bits (548), Expect = 2e-56, Method: Composition-based stats. Identities = 88/346 (25%), Positives = 159/346 (45%), Gaps = 49/346 (14%) Query: 9 YTVEVGDTNFTIHSRYI-NLRPIGSGAQGIVCAAYDTITQQN--VAIKKLSRPFQNVTHA 65 + V++ + + +G G G V A + + A+K++ + + Sbjct: 8 FKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQI----EGTGIS 63 Query: 66 KRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQM------ 119 A RE L++ + H N+I L F + + V+L+ + + +L +I+ Sbjct: 64 MSACREIALLRELKHPNVISLQKVFLSHAD----RKVWLLFDYAEHDLWHIIKFHRASKA 119 Query: 120 -----DLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK----ADCTLKILDFGL 170 L + LLYQ+L GI +LH+ ++HRDLKP+NI+V +KI D G Sbjct: 120 NKKPVQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGF 179 Query: 171 ARTAGTTFM----MTPYVVTRYYRAPEVILG-MGYTENVDIWSVGCIMGEMIRGGVLF-- 223 AR + + P VVT +YRAPE++LG YT+ +DIW++GCI E++ +F Sbjct: 180 ARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHC 239 Query: 224 -------PGTDHIDQWNKIIEQLGTPSPSFMQRLQ--PTVRNYVENRPRYTGYSFDRLFP 274 H DQ ++I +G P+ + ++ P +++ R T + Sbjct: 240 RQEDIKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNT-------YT 292 Query: 275 DGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEYI 320 + ++ + S A +LL K+L +DP +RI+ ++A++ Y Sbjct: 293 NCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYF 338 >4WUA-A nrPDB Length = 401 Score = 215 bits (548), Expect = 2e-56, Method: Composition-based stats. Identities = 85/385 (22%), Positives = 149/385 (38%), Gaps = 79/385 (20%) Query: 5 QHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTH 64 + ++ V++GD + RY +R +G G V ++D ++ VA+K + + Sbjct: 27 KGGYHLVKIGDL---FNGRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSA---EHY 80 Query: 65 AKRAYREFKLMKLV-----NHKN---IIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQV 116 + A E +L+K V N N ++ LL+ F + +V E++ +L + Sbjct: 81 TETALDEIRLLKSVRNSDPNDPNREMVVQLLDDFKISG--VNGTHICMVFEVLGHHLLKW 138 Query: 117 I----QMDLDHDRMSYLLYQMLCGIKHLHSA-GIIHRDLKPSNIVVKADCT--------- 162 I L + ++ Q+L G+ +LH+ IIH D+KP NI++ + Sbjct: 139 IIKSNYQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEA 198 Query: 163 ----------------------------------------LKILDFGLARTAGTTFMMTP 182 +KI D G A F T Sbjct: 199 TEWQRSGAPPPSGSAVSTAPATAGNFLVNPLEPKNAEKLKVKIADLGNACWVHKHF--TE 256 Query: 183 YVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTD------HIDQWNKII 236 + TR YR+ EV++G GY DIWS C+ E+ G LF D II Sbjct: 257 DIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALII 316 Query: 237 EQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNL 296 E LG P + + + + + + + + + S+ +A+ + Sbjct: 317 ELLGK-VPRKLIVAGKYSKEFFTKKGDLKHITKLKPWGLFEVLVEKYEWSQEEAAGFTDF 375 Query: 297 LSKMLVIDPEQRISVDEALKHEYIN 321 L ML + PE+R + E L+H ++N Sbjct: 376 LLPMLELIPEKRATAAECLRHPWLN 400 >2FO0-A nrPDB Length = 495 Score = 214 bits (546), Expect = 4e-56, Method: Composition-based stats. Identities = 53/276 (19%), Positives = 112/276 (40%), Gaps = 24/276 (8%) Query: 29 PIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLN 88 +G G G V VA+K L ++ + +E +MK + H N++ LL Sbjct: 224 KLGGGQYGEVYEGVWKKYSLTVAVKTLK---EDTMEVEEFLKEAAVMKEIKHPNLVQLLG 280 Query: 89 AFTPQRNLEEFQDVYLVMELMD-ANLCQVIQ----MDLDHDRMSYLLYQMLCGIKHLHSA 143 T + Y++ E M NL ++ +++ + Y+ Q+ +++L Sbjct: 281 VCTREPPF------YIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKK 334 Query: 144 GIIHRDLKPSNIVVKADCTLKILDFGLARTA--GTTFMMTPYVVTRYYRAPEVILGMGYT 201 IHR+L N +V + +K+ DFGL+R T + APE + ++ Sbjct: 335 NFIHRNLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFS 394 Query: 202 ENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQWNKI-----IEQLGTPSPSFMQRLQPTVR 255 D+W+ G ++ E+ G +PG D + + +E+ + ++ + Sbjct: 395 IKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQ 454 Query: 256 NYVENRPRYTG--YSFDRLFPDGLFPNDNNQNSRRK 289 +RP + +F+ +F + ++ + ++ Sbjct: 455 WNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKE 490 >4XEY-B nrPDB Length = 408 Score = 214 bits (545), Expect = 5e-56, Method: Composition-based stats. Identities = 54/275 (19%), Positives = 111/275 (40%), Gaps = 24/275 (8%) Query: 29 PIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLN 88 +G G G V VA+K L ++ + +E +MK + H N++ LL Sbjct: 132 KLGGGQYGEVYEGVWKKYSLTVAVKTLK---EDTMEVEEFLKEAAVMKEIKHPNLVQLLG 188 Query: 89 AFTPQRNLEEFQDVYLVMELMD-ANLCQVIQ----MDLDHDRMSYLLYQMLCGIKHLHSA 143 T + Y++ E M NL ++ +++ + Y+ Q+ +++L Sbjct: 189 VCTREPPF------YIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKK 242 Query: 144 GIIHRDLKPSNIVVKADCTLKILDFGLARTA--GTTFMMTPYVVTRYYRAPEVILGMGYT 201 IHRDL N +V + +K+ DFGL+R T + APE + ++ Sbjct: 243 NFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFS 302 Query: 202 ENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQWNKI-----IEQLGTPSPSFMQRLQPTVR 255 D+W+ G ++ E+ G +PG D + + +E+ + ++ + Sbjct: 303 IKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQ 362 Query: 256 NYVENRPRYTG--YSFDRLFPDGLFPNDNNQNSRR 288 +RP + +F+ +F + ++ + + Sbjct: 363 WNPSDRPSFAEIHQAFETMFQESSISDEVEKELGK 397 >4P5Q-A nrPDB Length = 361 Score = 214 bits (544), Expect = 6e-56, Method: Composition-based stats. Identities = 63/283 (22%), Positives = 114/283 (40%), Gaps = 30/283 (10%) Query: 2 TTAQHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQN---VAIKKLSRP 58 +T + E+ TN +I + +G+G G VC+ + + VAIK L Sbjct: 19 STQTVHEFAKELDATNISID------KVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVG 72 Query: 59 FQNVTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVI 117 + + E +M +H NII L T + V +V E M+ +L + Sbjct: 73 Y-TEKQRRDFLGEASIMGQFDHPNIIRLEGVVTKSK------PVMIVTEYMENGSLDSFL 125 Query: 118 QM---DLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTA 174 + ++ +L + G+K+L G +HRDL NI++ ++ K+ DFGL+R Sbjct: 126 RKHDAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVL 185 Query: 175 GTT----FMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGTDHI 229 + + + +PE I +T D+WS G ++ E++ G + + Sbjct: 186 EDDPEAAYTTRGGKIPIRWTSPEAIAYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQ 245 Query: 230 DQWNKIIEQLGTPSP-----SFMQRLQPTVRNYVENRPRYTGY 267 D + E P P + Q + + NRP++ Sbjct: 246 DVIKAVDEGYRLPPPMDCPAALYQLMLDCWQKDRNNRPKFEQI 288 >4C0T-A nrPDB Length = 974 Score = 213 bits (543), Expect = 9e-56, Method: Composition-based stats. Identities = 77/334 (23%), Positives = 134/334 (40%), Gaps = 69/334 (20%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQ-NVTHAKRAYREFKLMKLVNHK- 81 + + +G G+ V A D IT + A+K L + K E + ++++ Sbjct: 268 FKFGKELGEGSYSTVILATDKITGKQYAVKVLDKRHIIKEKKVKYVNIEKHALNRLSNRL 327 Query: 82 NIIGLLNAFTPQRNLEEFQDVYLVMELM-DANLCQVIQM--DLDHDRMSYLLYQMLCGIK 138 +I L F + +L Y V++ + L +I+ L+ + + Q+L IK Sbjct: 328 GVISLYFTFQDKDSL------YFVLDYASNGELLTLIKRYNTLNEECTRHFGAQILDAIK 381 Query: 139 HLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGT----------TFMMTPYVVTRY 188 ++H G+IHRDLKP NI++ ++I DFG AR +V T Sbjct: 382 YMHDNGVIHRDLKPENILLDDKMRIQITDFGTARLLEKKNDESEEYPVDVRAKSFVGTAE 441 Query: 189 YRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQ 248 Y +PE++ + D+W+ GCI+ +MI G F T+ + KI + Sbjct: 442 YVSPELLENKYCGKPGDVWAFGCIIYQMIAGKPPFKATNEYLTFQKITKL---------- 491 Query: 249 RLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQR 308 ++F FP + R+L+ K+LV+ P +R Sbjct: 492 -----------------QFAFSAGFPTII----------------RDLIKKILVLQPSRR 518 Query: 309 ISVDEALKHEYIN--VWYDAEEV---DAPAPEPY 337 ++ E KH + + D + + D P PY Sbjct: 519 ATIPEIQKHYFFQSVDFKDFDSIWLSDPPEIGPY 552 >6BDL-A nrPDB Length = 347 Score = 213 bits (542), Expect = 1e-55, Method: Composition-based stats. Identities = 72/348 (20%), Positives = 130/348 (37%), Gaps = 66/348 (18%) Query: 22 SRYINLRPIGSGAQGIVCAAYDTITQ-QNVAIKKLSRPFQ-NVTHAKRAYREFKLMKLVN 79 S + + +G G G V + + A+K L + + + E ++M+ + Sbjct: 34 SDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAH 93 Query: 80 HKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVI---QMDLDHDRMSYLLYQMLCG 136 I+ L F + L Y++ME I + + + ++ Sbjct: 94 SDFIVRLYRTFKDSKYL------YMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEA 147 Query: 137 IKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVIL 196 +LHS GII+RDLKP N+++ K++DFG A+ G + T Y APE+IL Sbjct: 148 FAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIIL 207 Query: 197 GMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRN 256 G+ + D WS+G +M E++ G F G D + +N I+ + Sbjct: 208 NKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGI----------------- 250 Query: 257 YVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRI-----SV 311 D + ++ A +A NL+ K+ +P +R+ V Sbjct: 251 ------------------------DMIEFPKKIAKNAANLIKKLCRDNPSERLGNLKNGV 286 Query: 312 DEALKHEYIN--VWYDAEEVDAPAP------EPYD-HSVDEREHTVEQ 350 + KH++ W + P P D + D ++ Sbjct: 287 KDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNDE 334 >6NPU-A nrPDB Length = 298 Score = 212 bits (541), Expect = 1e-55, Method: Composition-based stats. Identities = 55/300 (18%), Positives = 120/300 (40%), Gaps = 25/300 (8%) Query: 5 QHQHYTVEVGDTNFTIHSRYINLR-PIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVT 63 ++ ++ + + I ++ +G G G V VA+K L ++ Sbjct: 8 ENLYFQGSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLK---EDTM 64 Query: 64 HAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQ---- 118 + +E +MK + H N++ LL T + Y++ E M NL ++ Sbjct: 65 EVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPF------YIITEFMTYGNLLDYLRECNR 118 Query: 119 MDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTA--GT 176 +++ + Y+ Q+ +++L IHRDL N +V + +K+ DFGL+R T Sbjct: 119 QEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDT 178 Query: 177 TFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQWNKI 235 + APE + ++ D+W+ G ++ E+ G +PG D + + Sbjct: 179 YTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELL 238 Query: 236 -----IEQLGTPSPSFMQRLQPTVRNYVENRPRYTG--YSFDRLFPDGLFPNDNNQNSRR 288 +E+ + ++ + +RP + +F+ +F + ++ + + Sbjct: 239 EKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGK 298 >4TNB-A nrPDB Length = 590 Score = 212 bits (541), Expect = 2e-55, Method: Composition-based stats. Identities = 65/308 (21%), Positives = 120/308 (38%), Gaps = 56/308 (18%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKL-SRPFQNVTHAKRAYREFKLMKLVNHKN 82 + R +G G G VCA T + A K+L + + A E ++++ VN + Sbjct: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQF 245 Query: 83 IIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVI-----QMDLDHDRMSYLLYQMLCGI 137 ++ L A+ + L LV+ +M+ + + +R + ++LCG+ Sbjct: 246 VVNLAYAYETKDAL------CLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGL 299 Query: 138 KHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILG 197 + LH ++RDLKP NI++ ++I D GLA ++ V T Y APEV+ Sbjct: 300 EDLHHENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNN 359 Query: 198 MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNY 257 Y + D W +GC++ EMI G F G + ++ ++ Sbjct: 360 QRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRV------------------ 401 Query: 258 VENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRIS-----VD 312 S + + +A+++ +L D +QR+ Sbjct: 402 ---------------------LETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEEAA 440 Query: 313 EALKHEYI 320 E +H + Sbjct: 441 EVKRHPFF 448 >4MD7-E nrPDB Length = 391 Score = 212 bits (540), Expect = 2e-55, Method: Composition-based stats. Identities = 72/320 (22%), Positives = 138/320 (43%), Gaps = 19/320 (5%) Query: 5 QHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTH 64 +++ E + Y +R +G G V A + + + Sbjct: 20 PREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEK-----VVVKILKPVK 74 Query: 65 AKRAYREFKLMKLVNH-KNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDH 123 K+ RE K+++ + NII L + + LV E ++ + + L Sbjct: 75 KKKIKREIKILENLRGGPNIITLADIVKDPVSRTPA----LVFEHVNNTDFKQLYQTLTD 130 Query: 124 DRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCT-LKILDFGLARTAGTTFMMTP 182 + + +Y++L + + HS GI+HRD+KP N+++ + L+++D+GLA Sbjct: 131 YDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNV 190 Query: 183 YVVTRYYRAPEVIL-GMGYTENVDIWSVGCIMGEM-IRGGVLFPGTDHIDQWNKIIEQLG 240 V +RY++ PE+++ Y ++D+WS+GC++ M R F G D+ DQ +I + LG Sbjct: 191 RVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLG 250 Query: 241 TPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKM 300 T + L + Y R +++N + +A + L K+ Sbjct: 251 T------EDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKL 304 Query: 301 LVIDPEQRISVDEALKHEYI 320 L D + R++ EA++H Y Sbjct: 305 LRYDHQSRLTAREAMEHPYF 324 >5UNP-A nrPDB Length = 369 Score = 212 bits (539), Expect = 2e-55, Method: Composition-based stats. Identities = 84/372 (22%), Positives = 153/372 (41%), Gaps = 54/372 (14%) Query: 4 AQHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAY-DTITQQNVAIKKLSRPFQNV 62 H VGD + RY + +G G G V VA+K + NV Sbjct: 19 DAEGHLIYHVGDW---LQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIK----NV 71 Query: 63 THAKRAYR-EFKLMKLVNHKN------IIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQ 115 K A R E +++ +N K+ + + + F ++ + EL+ + Sbjct: 72 EKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHM------CISFELLGLSTFD 125 Query: 116 VIQ----MDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIV-VKADCT-------- 162 ++ + ++ ++ +Q+ +K LH + H DLKP NI+ V +D Sbjct: 126 FLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKK 185 Query: 163 ----------LKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCI 212 ++++DFG A + V TR+YRAPEVIL +G+++ D+WS+GCI Sbjct: 186 RDERSVKSTAVRVVDFGSATFDHEHH--STIVSTRHYRAPEVILELGWSQPCDVWSIGCI 243 Query: 213 MGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRL 272 + E G LF D+ + ++E++ P PS M R + + R + + Sbjct: 244 IFEYYVGFTLFQTHDNREHL-AMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGR 302 Query: 273 F--PDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEYINVWYDAEEVD 330 + + + + +L+ ML +P +R+++ EAL+H + Sbjct: 303 YVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLR-----A 357 Query: 331 APAPEPYDHSVD 342 P + +D S D Sbjct: 358 EPPNKLWDSSRD 369 >4AN9-A nrPDB Length = 301 Score = 212 bits (539), Expect = 2e-55, Method: Composition-based stats. Identities = 69/314 (21%), Positives = 127/314 (40%), Gaps = 54/314 (17%) Query: 21 HSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNH 80 + + +G+G G+V + +A K + + + RE +++ N Sbjct: 8 DDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIK-PAIRNQIIRELQVLHECNS 66 Query: 81 KNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN-LCQVIQM--DLDHDRMSYLLYQMLCGI 137 I+G AF ++ + ME MD L QV++ + + + ++ G+ Sbjct: 67 PYIVGFYGAFYSDG------EISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGL 120 Query: 138 KHL-HSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVIL 196 +L I+HRD+KPSNI+V + +K+ DFG++ M +V TR Y +PE + Sbjct: 121 TYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID-EMANEFVGTRSYMSPERLQ 179 Query: 197 GMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRN 256 G Y+ DIWS+G + EM G P + + I+ + P P + Sbjct: 180 GTHYSVQSDIWSMGLSLVEMAVGRYPRPPMAIFELLDYIVNE---PPPKLPSAV------ 230 Query: 257 YVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALK 316 + + ++ ++K L+ +P +R + + + Sbjct: 231 --------------------------------FSLEFQDFVNKCLIKNPAERADLKQLMV 258 Query: 317 HEYINVWYDAEEVD 330 H +I DAEEVD Sbjct: 259 HAFIK-RSDAEEVD 271 >6HMD-A nrPDB Length = 365 Score = 211 bits (538), Expect = 3e-55, Method: Composition-based stats. Identities = 73/318 (22%), Positives = 145/318 (45%), Gaps = 19/318 (5%) Query: 7 QHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAK 66 +++ E ++ Y +R +G G V A + + ++ K Sbjct: 38 EYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNE-----RVVVKILKPVKKK 92 Query: 67 RAYREFKLMKLVNHK-NIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDR 125 + RE K+++ + NII L++ + LV E ++ + + L Sbjct: 93 KIKREVKILENLRGGTNIIKLIDTVKDPVSKTPA----LVFEYINNTDFKQLYQILTDFD 148 Query: 126 MSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKA-DCTLKILDFGLARTAGTTFMMTPYV 184 + + +Y++L + + HS GI+HRD+KP N+++ L+++D+GLA V Sbjct: 149 IRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRV 208 Query: 185 VTRYYRAPEVIL-GMGYTENVDIWSVGCIMGEM-IRGGVLFPGTDHIDQWNKIIEQLGTP 242 +RY++ PE+++ Y ++D+WS+GC++ M R F G D+ DQ +I + LGT Sbjct: 209 ASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGT- 267 Query: 243 SPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLV 302 + L ++ Y + + + +++N + +A +LL K+L Sbjct: 268 -----EELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLR 322 Query: 303 IDPEQRISVDEALKHEYI 320 D +QR++ EA++H Y Sbjct: 323 YDHQQRLTAKEAMEHPYF 340 >4KIK-B nrPDB Length = 677 Score = 211 bits (538), Expect = 3e-55, Method: Composition-based stats. Identities = 73/296 (24%), Positives = 121/296 (40%), Gaps = 29/296 (9%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNI 83 + +G+G G V ++ T + +AIK+ + + + +R E ++M+ + H N+ Sbjct: 21 WEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQEL-SPRNRERWCLEIQIMRRLTHPNV 79 Query: 84 IGLLNAFTPQRNLEEFQDVYLVMELM-DANLCQVIQM-----DLDHDRMSYLLYQMLCGI 137 + + +NL L ME +L + + L + LL + + Sbjct: 80 VAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASAL 139 Query: 138 KHLHSAGIIHRDLKPSNIVV---KADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEV 194 ++LH IIHRDLKP NIV+ + KI+D G A+ + T +V T Y APE+ Sbjct: 140 RYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPEL 199 Query: 195 ILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTV 254 + YT VD WS G + E I G F QW+ + Q + L TV Sbjct: 200 LEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGTV 259 Query: 255 RNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRIS 310 + +S +P+ L + + L ML+ P QR + Sbjct: 260 K-----------FSSSLPYPNNLNSVLAERLEKW--------LQLMLMWHPRQRGT 296 >3TKU-A nrPDB Length = 433 Score = 211 bits (537), Expect = 4e-55, Method: Composition-based stats. Identities = 67/343 (19%), Positives = 129/343 (37%), Gaps = 54/343 (15%) Query: 21 HSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSR-PFQNVTHAKRAYREFKLMKLVN 79 + ++ IG GA G V T++ A+K L++ E ++ + Sbjct: 89 REDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGD 148 Query: 80 HKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGIKH 139 + I L AF + +L D Y+ +L+ L + L D + + +M+ I Sbjct: 149 CQWITALHYAFQDENHLYLVMDYYVGGDLL--TLLSKFEDKLPEDMARFYIGEMVLAIDS 206 Query: 140 LHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTP--YVVTRYYRAPEVILG 197 +H +HRD+KP N+++ + +++ DFG + V T Y +PE++ Sbjct: 207 IHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQA 266 Query: 198 M-----GYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQP 252 M Y D WS+G M EM+ G F ++ + KI+ Sbjct: 267 MEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNH-------------- 312 Query: 253 TVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRI--- 309 E R ++ + D + +A++L+ + L+ E+R+ Sbjct: 313 ------EERFQFPSHVTD------------------VSEEAKDLIQR-LICSRERRLGQN 347 Query: 310 SVDEALKHEYIN--VWYDAEEVDAPAPEPYDHSVDEREHTVEQ 350 +++ KH + W + ++AP D V+ Sbjct: 348 GIEDFKKHAFFEGLNWENIRNLEAPYIPDVSSPSDTSNFDVDD 390 >5XVU-A nrPDB Length = 332 Score = 210 bits (535), Expect = 7e-55, Method: Composition-based stats. Identities = 83/328 (25%), Positives = 150/328 (45%), Gaps = 23/328 (7%) Query: 4 AQHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVT 63 ++Y + + + +RY ++ IG G V YDT + A Sbjct: 13 KPKEYYDYDNLELQWNKPNRYEIMKKIGRGKYSEVFNGYDTECNRPCA-----IKVLKPV 67 Query: 64 HAKRAYREFKLMKLVNH-KNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLD 122 K+ RE K+++ +N NII LL+ L+ E ++ + + Sbjct: 68 KKKKIKREIKILQNLNGGPNIIKLLDIVKDPVTKTPS----LIFEYINNIDFKTLYPKFT 123 Query: 123 HDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-ADCTLKILDFGLARTAGTTFMMT 181 + Y +YQ+L + + HS GI+HRD+KP NI++ + ++++ +GLA Sbjct: 124 DKDIRYYIYQILKALDYCHSQGIMHRDVKPHNIMIDHENRQIRLISWGLAEFYHPGQEYN 183 Query: 182 PYVVTRYYRAPEVILG-MGYTENVDIWSVGCIMGEM-IRGGVLFPGTDHIDQWNKIIEQL 239 V +RYY+ PE+++ Y ++DIWS+GC++ M + F G D+ DQ KI + L Sbjct: 184 VRVASRYYKGPELLIDLQLYDYSLDIWSLGCMLAGMIFKKEPFFCGHDNYDQLVKIAKVL 243 Query: 240 GTPSPSFMQRLQPTVRNY-VENRPRYTGYSFD-RLFPDGLFPNDNNQNSRRKASDARNLL 297 GT + L ++ Y ++ +P Y + P F +N + + + +L+ Sbjct: 244 GT------EDLHAYLKKYNIKLKPHYLNILGEYERKPWSHFLTQSNIDIAK--DEVIDLI 295 Query: 298 SKMLVIDPEQRISVDEALKHEYINVWYD 325 KML+ D +RI+ EA++H Y + Sbjct: 296 DKMLIYDHAKRIAPKEAMEHPYFREVRE 323 >2WTK-C nrPDB Length = 305 Score = 210 bits (535), Expect = 8e-55, Method: Composition-based stats. Identities = 77/347 (22%), Positives = 132/347 (38%), Gaps = 66/347 (19%) Query: 20 IHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQN--VTHAKRAYREFKLMKL 77 + +Y+ +G G+ G V D+ T A+K L + +E +L++ Sbjct: 3 LIGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRR 62 Query: 78 VNHKNIIGLLNAFTPQRNLEEFQDVYLVMEL----MDANLCQVIQMDLDHDRMSYLLYQM 133 + HKN+I L++ EE Q +Y+VME M L V + + Q+ Sbjct: 63 LRHKNVIQLVDVLYN----EEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQL 118 Query: 134 LCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGT---TFMMTPYVVTRYYR 190 + G+++LHS GI+H+D+KP N+++ TLKI G+A + ++ Sbjct: 119 IDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISALGVAEALHPFAADDTCRTSQGSPAFQ 178 Query: 191 APEVILGMG--YTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQ 248 PE+ G+ VDIWS G + + G F G D K+ E +G S + Sbjct: 179 PPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEG----DNIYKLFENIGKGSYAIPG 234 Query: 249 RLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQR 308 P + +LL ML +P +R Sbjct: 235 DCGPPLS---------------------------------------DLLKGMLEYEPAKR 255 Query: 309 ISVDEALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELI 355 S+ + +H + + E P P D T ++W+ + Sbjct: 256 FSIRQIRQHSWFRKKHPPAEAPVPIPPSPD--------TKDRWRSMT 294 >4UY9-A nrPDB Length = 323 Score = 210 bits (534), Expect = 1e-54, Method: Composition-based stats. Identities = 73/261 (27%), Positives = 113/261 (43%), Gaps = 30/261 (11%) Query: 28 RPIGSGAQGIVCAAYDTITQQNVAIKKLS-RPFQNVTHA-KRAYREFKLMKLVNHKNIIG 85 IG G G V A+ VA+K P ++++ + +E KL ++ H NII Sbjct: 15 EIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIA 72 Query: 86 LLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQ--MDLDHDRMSYLLYQMLCGIKHLHSA 143 L + NL LVME + + D + Q+ G+ +LH Sbjct: 73 LRGVCLKEPNL------CLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDE 126 Query: 144 GI---IHRDLKPSNIVVK--------ADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAP 192 I IHRDLK SNI++ ++ LKI DFGLAR T M+ T + AP Sbjct: 127 AIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSA-AGTYAWMAP 185 Query: 193 EVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQ-WNKIIEQLGTPSP-----SF 246 EVI +++ D+WS G ++ E++ G V F G D + + + +L P P F Sbjct: 186 EVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPF 245 Query: 247 MQRLQPTVRNYVENRPRYTGY 267 + ++ +RP +T Sbjct: 246 AKLMEDCWNPDPHSRPSFTNI 266 >3PFQ-A nrPDB Length = 674 Score = 210 bits (534), Expect = 1e-54, Method: Composition-based stats. Identities = 58/245 (23%), Positives = 101/245 (41%), Gaps = 12/245 (4%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPF-QNVTHAKRAYREFKLMKL-VNHK 81 + L +G G+ G V + T + A+K L + + E +++ L Sbjct: 343 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 402 Query: 82 NIIGLLNAFTPQRNLEEFQDVYLVMELMDA-NLCQVIQM--DLDHDRMSYLLYQMLCGIK 138 + L + F L Y VME ++ +L IQ + ++ G+ Sbjct: 403 FLTQLHSCFQTMDRL------YFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 456 Query: 139 HLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAG-TTFMMTPYVVTRYYRAPEVILG 197 L S GII+RDLK N+++ ++ +KI DFG+ + + T Y APE+I Sbjct: 457 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAY 516 Query: 198 MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNY 257 Y ++VD W+ G ++ EM+ G F G D + + I+E S + + Sbjct: 517 QPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGL 576 Query: 258 VENRP 262 + P Sbjct: 577 MTKHP 581 >1S9I-A nrPDB Length = 354 Score = 209 bits (533), Expect = 1e-54, Method: Composition-based stats. Identities = 75/332 (22%), Positives = 136/332 (40%), Gaps = 27/332 (8%) Query: 11 VEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYR 70 +VG+ + + +G+G G+V + +A K + + + R Sbjct: 8 AKVGELK---DDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIK-PAIRNQIIR 63 Query: 71 EFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN-LCQVIQ--MDLDHDRMS 127 E +++ N I+G AF ++ + ME MD L QV++ + + + Sbjct: 64 ELQVLHECNSPYIVGFYGAFYSDG------EISICMEHMDGGSLDQVLKEAKRIPEEILG 117 Query: 128 YLLYQMLCGIKHL-HSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVT 186 + +L G+ +L I+HRD+KPSNI+V + +K+ DFG++ + M +V T Sbjct: 118 KVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS-MANSFVGT 176 Query: 187 RYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSF 246 R Y APE + G Y+ DIWS+G + E+ G P D + + Sbjct: 177 RSYMAPERLQGTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGE 236 Query: 247 MQRLQPTVR--------NYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLS 298 + P R + +++RP + + P N D + ++ Sbjct: 237 PHSISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVF---TPDFQEFVN 293 Query: 299 KMLVIDPEQRISVDEALKHEYINVWYDAEEVD 330 K L+ +P +R + H +I + EEVD Sbjct: 294 KCLIKNPAERADLKMLTNHTFIK-RSEVEEVD 324 >5MJB-A nrPDB Length = 305 Score = 209 bits (533), Expect = 1e-54, Method: Composition-based stats. Identities = 61/259 (23%), Positives = 100/259 (38%), Gaps = 26/259 (10%) Query: 28 RPIGSGAQGIVCAAYDTITQQN---VAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNII 84 IG+G G V + + VAIK L + + + E +M +H+NII Sbjct: 32 EVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGY-SEKQRRDFLSEASIMGQFDHRNII 90 Query: 85 GLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMD----LDHDRMSYLLYQMLCGIKHL 140 L T R V ++ E M+ ++ +L + G+K+L Sbjct: 91 RLEGVVTKSR------PVMIITEFMENCALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYL 144 Query: 141 HSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYV------VTRYYRAPEV 194 +HRDL NI+V ++ K+ DFGL+R Y + + APE Sbjct: 145 SEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEA 204 Query: 195 ILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQWNKIIEQLGTPSP-----SFMQ 248 I +T D+WS G +M E++ G + + D N I + P P + Q Sbjct: 205 IAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPAALHQ 264 Query: 249 RLQPTVRNYVENRPRYTGY 267 + + +RPR+ Sbjct: 265 LMLDCWQKDRNSRPRFAEI 283 >2WQN-A nrPDB Length = 310 Score = 209 bits (533), Expect = 1e-54, Method: Composition-based stats. Identities = 71/269 (26%), Positives = 113/269 (42%), Gaps = 23/269 (8%) Query: 14 GDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSR-PFQNVTHAKRAYREF 72 D + + + + IG G V A + VA+KK+ + +E Sbjct: 24 PDMGYNTLANFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEI 83 Query: 73 KLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQ------MDLDHDR 125 L+K +NH N+I +F L +V+EL D +L ++I+ + Sbjct: 84 DLLKQLNHPNVIKYYASFIEDNELN------IVLELADAGDLSRMIKHFKKQKRLIPERT 137 Query: 126 MSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGT-TFMMTPYV 184 + Q+ ++H+HS ++HRD+KP+N+ + A +K+ D GL R + T V Sbjct: 138 VWKYFVQLCSALEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLV 197 Query: 185 VTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTD-HIDQWNKIIEQLGTPS 243 T YY +PE I GY DIWS+GC++ EM F G ++ K IEQ P Sbjct: 198 GTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPP 257 Query: 244 -------PSFMQRLQPTVRNYVENRPRYT 265 Q + + E RP T Sbjct: 258 LPSDHYSEELRQLVNMCINPDPEKRPDVT 286 >3DTC-A nrPDB Length = 271 Score = 209 bits (532), Expect = 2e-54, Method: Composition-based stats. Identities = 72/261 (27%), Positives = 111/261 (42%), Gaps = 30/261 (11%) Query: 28 RPIGSGAQGIVCAAYDTITQQNVAIKKLS-RPFQNVTHA-KRAYREFKLMKLVNHKNIIG 85 IG G G V A+ VA+K P ++++ + +E KL ++ H NII Sbjct: 13 EIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIA 70 Query: 86 LLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQ--MDLDHDRMSYLLYQMLCGIKHLHSA 143 L + NL LVME + + D + Q+ G+ +LH Sbjct: 71 LRGVCLKEPNL------CLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDE 124 Query: 144 GI---IHRDLKPSNIVVK--------ADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAP 192 I IHRDLK SNI++ ++ LKI DFGLAR T M + AP Sbjct: 125 AIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKM-SAAGAYAWMAP 183 Query: 193 EVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQ-WNKIIEQLGTPSP-----SF 246 EVI +++ D+WS G ++ E++ G V F G D + + + +L P P F Sbjct: 184 EVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPF 243 Query: 247 MQRLQPTVRNYVENRPRYTGY 267 + ++ +RP +T Sbjct: 244 AKLMEDCWNPDPHSRPSFTNI 264 >5H2U-A nrPDB Length = 267 Score = 209 bits (531), Expect = 2e-54, Method: Composition-based stats. Identities = 68/258 (26%), Positives = 112/258 (43%), Gaps = 21/258 (8%) Query: 21 HSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNH 80 + R +GSG G V + VAIK +SR N+ H + E + MK + H Sbjct: 5 REEFTLCRKLGSGYFGEVFEGLWK-DRVQVAIKVISR--DNLLHQQMLQSEIQAMKKLRH 61 Query: 81 KNIIGLLNAFTPQRNLEEFQDVYLVMELM-DANLCQVIQ----MDLDHDRMSYLLYQMLC 135 K+I+ L + VY++ ELM +L ++++ L + + +Q+ Sbjct: 62 KHILALYAVVSV------GDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAE 115 Query: 136 GIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRY-YRAPEV 194 G+ +L S IHRDL NI+V + K+ DFGLAR ++ Y + APE Sbjct: 116 GMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEA 175 Query: 195 ILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQWNKIIEQLGTPS-----PSFMQ 248 + Y+ D+WS G ++ EM G V +PG + + + ++ P PS + Sbjct: 176 LSRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHK 235 Query: 249 RLQPTVRNYVENRPRYTG 266 + E RP + Sbjct: 236 LMLTCWCRDPEQRPTFKA 253 >3C51-A nrPDB Length = 543 Score = 208 bits (530), Expect = 3e-54, Method: Composition-based stats. Identities = 74/335 (22%), Positives = 130/335 (38%), Gaps = 61/335 (18%) Query: 21 HSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTH-AKRAYREFKLMKLVN 79 +++ R +G G G V A T + A KKL++ + A E K++ V+ Sbjct: 184 EDWFLDFRVLGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILAKVH 243 Query: 80 HKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHD-------RMSYLLYQ 132 + I+ L AF + D+ LVM +M+ + ++D D R + Q Sbjct: 244 SRFIVSLAYAFETK------TDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQ 297 Query: 133 MLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMT-PYVVTRYYRA 191 ++ G++HLH II+RDLKP N+++ D ++I D GLA T Y T + A Sbjct: 298 IVSGLEHLHQRNIIYRDLKPENVLLDDDGNVRISDLGLAVELKAGQTKTKGYAGTPGFMA 357 Query: 192 PEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQ 251 PE++LG Y +VD +++G + EMI F + ++ +++ + ++ + Sbjct: 358 PELLLGEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKQRVLEQAVTYPDKF- 416 Query: 252 PTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRI-- 309 + +++ +L DPE+R+ Sbjct: 417 --------------------------------------SPASKDFCEALLQKDPEKRLGF 438 Query: 310 ---SVDEALKHEYINV--WYDAEEVDAPAPEPYDH 339 S D H W E P D Sbjct: 439 RDGSCDGLRTHPLFRDISWRQLEAGMLTPPFVPDS 473 >4AW2-A nrPDB Length = 437 Score = 208 bits (529), Expect = 4e-54, Method: Composition-based stats. Identities = 69/343 (20%), Positives = 122/343 (35%), Gaps = 54/343 (15%) Query: 21 HSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSR-PFQNVTHAKRAYREFKLMKLVN 79 + L+ IG GA G V + A+K L++ E ++ + Sbjct: 73 REDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGD 132 Query: 80 HKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGIKH 139 K I L AF NL D Y+ +L+ L + L + + L +M+ I Sbjct: 133 SKWITTLHYAFQDDNNLYLVMDYYVGGDLL--TLLSKFEDRLPEEMARFYLAEMVIAIDS 190 Query: 140 LHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTA--GTTFMMTPYVVTRYYRAPEVIL- 196 +H +HRD+KP NI++ + +++ DFG T + V T Y +PE++ Sbjct: 191 VHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQA 250 Query: 197 ----GMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQP 252 Y D WS+G M EM+ G F ++ + KI+ Sbjct: 251 MEGGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMN--------------- 295 Query: 253 TVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRI--- 309 + F D + +A++L+ + L+ E R+ Sbjct: 296 ----------HKERFQFPTQVTD-------------VSENAKDLIRR-LICSREHRLGQN 331 Query: 310 SVDEALKHEYIN--VWYDAEEVDAPAPEPYDHSVDEREHTVEQ 350 +++ KH + + W + +AP D V+ Sbjct: 332 GIEDFKKHPFFSGIDWDNIRNCEAPYIPEVSSPTDTSNFDVDD 374 >6E2O-A nrPDB Length = 295 Score = 208 bits (529), Expect = 4e-54, Method: Composition-based stats. Identities = 74/306 (24%), Positives = 124/306 (40%), Gaps = 62/306 (20%) Query: 29 PIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLN 88 +G G GIV A D Q +AIK++ P ++ +++ + E L K + HKNI+ L Sbjct: 29 VLGKGTYGIVYAGRDLSNQVRIAIKEI--PERDSRYSQPLHEEIALHKHLKHKNIVQYLG 86 Query: 89 AFTPQRNLEEFQDVYLVMELMDANLCQVIQMDL------DHDRMSYLLYQMLCGIKHLHS 142 +F+ ++ F ME + + + + + Q+L G+K+LH Sbjct: 87 SFSENGFIKIF------MEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHD 140 Query: 143 AGIIHRDLKPSNIVVKA-DCTLKILDFGLA-RTAGTTFMMTPYVVTRYYRAPEVILG--M 198 I+HRD+K N+++ LKI DFG + R AG + T Y APE+I Sbjct: 141 NQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPR 200 Query: 199 GYTENVDIWSVGCIMGEMIRGGVLFP--GTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRN 256 GY + DIWS+GC + EM G F G + + ++ P M Sbjct: 201 GYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESM--------- 251 Query: 257 YVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALK 316 +++A+ + K DP++R ++ L Sbjct: 252 ---------------------------------SAEAKAFILKCFEPDPDKRACANDLLV 278 Query: 317 HEYINV 322 E++ V Sbjct: 279 DEFLKV 284 >2I0E-A nrPDB Length = 353 Score = 207 bits (528), Expect = 4e-54, Method: Composition-based stats. Identities = 58/245 (23%), Positives = 101/245 (41%), Gaps = 12/245 (4%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQ-NVTHAKRAYREFKLMKL-VNHK 81 + L +G G+ G V + T + A+K L + + E +++ L Sbjct: 22 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 81 Query: 82 NIIGLLNAFTPQRNLEEFQDVYLVMELMDA-NLCQVIQM--DLDHDRMSYLLYQMLCGIK 138 + L + F L Y VME ++ +L IQ + ++ G+ Sbjct: 82 FLTQLHSCFQTMDRL------YFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 135 Query: 139 HLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAG-TTFMMTPYVVTRYYRAPEVILG 197 L S GII+RDLK N+++ ++ +KI DFG+ + + T Y APE+I Sbjct: 136 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAY 195 Query: 198 MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNY 257 Y ++VD W+ G ++ EM+ G F G D + + I+E S + + Sbjct: 196 QPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGL 255 Query: 258 VENRP 262 + P Sbjct: 256 MTKHP 260 >5VO2-A nrPDB Length = 300 Score = 207 bits (528), Expect = 5e-54, Method: Composition-based stats. Identities = 64/277 (23%), Positives = 110/277 (39%), Gaps = 26/277 (9%) Query: 25 INLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNII 84 ++L+ +GSGAQG V + VA+KK+ + + K ++ + H NII Sbjct: 15 LDLQWVGSGAQGAVFLGRFH--GEEVAVKKVRDLKET---------DIKHLRKLKHPNII 63 Query: 85 GLLNAFTPQRNLEEFQDVYLVMELM-DANLCQVIQ--MDLDHDRMSYLLYQMLCGIKHLH 141 T ++ME L +V++ + + + G+ +LH Sbjct: 64 TFKGVCTQAPC------YCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLH 117 Query: 142 SAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGYT 201 IIHRDLK N+++ D +KI DFG ++ + T + APEVI + Sbjct: 118 LHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVS 177 Query: 202 ENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKI-IEQLGTPSPS-----FMQRLQPTVR 255 E VDIWS G ++ E++ G + + D + L P PS F L+ Sbjct: 178 EKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWN 237 Query: 256 NYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASD 292 + NRP + + + + ++ Sbjct: 238 SKPRNRPSFRQILLHLDIASADVLSTPQETYFKSQAE 274 >2J0K-A nrPDB Length = 656 Score = 207 bits (527), Expect = 5e-54, Method: Composition-based stats. Identities = 62/261 (23%), Positives = 100/261 (38%), Gaps = 23/261 (8%) Query: 21 HSRYINLRPIGSGAQGIVCAAYDTITQ---QNVAIKKLSRPFQNVTHAKRAYREFKLMKL 77 R R IG G G V + VAIK + + ++ +E M+ Sbjct: 389 RERIELGRCIGEGQFGDVHQGIYMSPENPAMAVAIKTCKNCTSD-SVREKFLQEALTMRQ 447 Query: 78 VNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMD----ANLCQVIQMDLDHDRMSYLLYQM 133 +H +I+ L+ T V+++MEL + QV + LD + YQ+ Sbjct: 448 FDHPHIVKLIGVITEN-------PVWIIMELCTLGELRSFLQVRKFSLDLASLILYAYQL 500 Query: 134 LCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVV--TRYYRA 191 + +L S +HRD+ N++V A +K+ DFGL+R + + A Sbjct: 501 STALAYLESKRFVHRDIAARNVLVSATDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMA 560 Query: 192 PEVILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQWNKIIEQLGTP-----SPS 245 PE I +T D+W G M E++ G F G + D +I P P+ Sbjct: 561 PESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPT 620 Query: 246 FMQRLQPTVRNYVENRPRYTG 266 + RPR+T Sbjct: 621 LYSLMTKCWAYDPSRRPRFTE 641 >1JPA-A nrPDB Length = 312 Score = 207 bits (527), Expect = 6e-54, Method: Composition-based stats. Identities = 60/259 (23%), Positives = 105/259 (40%), Gaps = 26/259 (10%) Query: 28 RPIGSGAQGIVCAAYDTITQQN---VAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNII 84 + IG+G G VC+ + + + VAIK L + + E +M +H N+I Sbjct: 39 QVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGY-TEKQRRDFLSEASIMGQFDHPNVI 97 Query: 85 GLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQM---DLDHDRMSYLLYQMLCGIKHL 140 L T V ++ E M+ +L ++ ++ +L + G+K+L Sbjct: 98 HLEGVVTKS------TPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYL 151 Query: 141 HSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYV------VTRYYRAPEV 194 +HRDL NI+V ++ K+ DFGL+R Y + + APE Sbjct: 152 ADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEA 211 Query: 195 ILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQWNKIIEQLGTPSP-----SFMQ 248 I +T D+WS G +M E++ G + + D N I + P P + Q Sbjct: 212 IQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQ 271 Query: 249 RLQPTVRNYVENRPRYTGY 267 + + +RP++ Sbjct: 272 LMLDCWQKDRNHRPKFGQI 290 >6EII-A nrPDB Length = 352 Score = 207 bits (527), Expect = 7e-54, Method: Composition-based stats. Identities = 72/320 (22%), Positives = 138/320 (43%), Gaps = 19/320 (5%) Query: 5 QHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTH 64 +++ E + Y +R +G G V A + + + Sbjct: 43 PSEYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEK-----VVVKILKPVK 97 Query: 65 AKRAYREFKLMKLVNH-KNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDH 123 K+ RE K+++ + NII L + + LV E ++ + + L Sbjct: 98 KKKIKREIKILENLRGGPNIITLADIVKDPVSRTPA----LVFEHVNNTDFKQLYQTLTD 153 Query: 124 DRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCT-LKILDFGLARTAGTTFMMTP 182 + + +Y++L + + HS GI+HRD+KP N+++ + L+++D+GLA Sbjct: 154 YDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNV 213 Query: 183 YVVTRYYRAPEVIL-GMGYTENVDIWSVGCIMGEM-IRGGVLFPGTDHIDQWNKIIEQLG 240 V +RY++ PE+++ Y ++D+WS+GC++ M R F G D+ DQ +I + LG Sbjct: 214 RVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLG 273 Query: 241 TPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKM 300 T + L + Y R +++N + +A + L K+ Sbjct: 274 T------EDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKL 327 Query: 301 LVIDPEQRISVDEALKHEYI 320 L D + R++ EA++H Y Sbjct: 328 LRYDHQSRLTAREAMEHPYF 347 >3A8W-A nrPDB Length = 345 Score = 207 bits (526), Expect = 8e-54, Method: Composition-based stats. Identities = 68/331 (20%), Positives = 126/331 (38%), Gaps = 54/331 (16%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYR-EFKLMKL-VNHK 81 + LR IG G+ V T + A+K + + N + E + + NH Sbjct: 11 FDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHP 70 Query: 82 NIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVI---QMDLDHDRMSYLLYQMLCGIK 138 ++GL + F + L + V+E ++ Q L + + ++ + Sbjct: 71 FLVGLHSCFQTESRL------FFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALN 124 Query: 139 HLHSAGIIHRDLKPSNIVVKADCTLKILDFGLART-AGTTFMMTPYVVTRYYRAPEVILG 197 +LH GII+RDLK N+++ ++ +K+ D+G+ + + + T Y APE++ G Sbjct: 125 YLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRG 184 Query: 198 MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNY 257 Y +VD W++G +M EM+ G F I+ P + L + Sbjct: 185 EDYGFSVDWWALGVLMFEMMAGRSPFD----------IVGSSDNPDQNTEDYLFQVILEK 234 Query: 258 VENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISV------ 311 PR + A ++L L DP++R+ Sbjct: 235 QIRIPR------------------------SLSVKAASVLKSFLNKDPKERLGCHPQTGF 270 Query: 312 DEALKHEYI-NVWYDAEEVDAPAPEPYDHSV 341 + H + NV +D E P P+ ++ Sbjct: 271 ADIQGHPFFRNVDWDMMEQKQVVP-PFKPNI 300 >2Y6O-A nrPDB Length = 291 Score = 207 bits (526), Expect = 9e-54, Method: Composition-based stats. Identities = 58/257 (22%), Positives = 100/257 (38%), Gaps = 24/257 (9%) Query: 28 RPIGSGAQGIVCAAYDTITQQN---VAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNII 84 + IG G G VC+ + + VAIK L + + + E +M +H NII Sbjct: 20 KVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTD-KQRRDFLSEASIMGQFDHPNII 78 Query: 85 GLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMD----LDHDRMSYLLYQMLCGIKHL 140 L T + V ++ E M+ ++ +L + G+K+L Sbjct: 79 HLEGVVTK------CKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYL 132 Query: 141 HSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTT----FMMTPYVVTRYYRAPEVIL 196 +HRDL NI+V ++ K+ DFG++R + + + APE I Sbjct: 133 SDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIA 192 Query: 197 GMGYTENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQWNKIIEQLGTPSP-----SFMQRL 250 +T D+WS G +M E++ G + + D I E P P + Q + Sbjct: 193 YRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPPMDCPIALHQLM 252 Query: 251 QPTVRNYVENRPRYTGY 267 + +RP++ Sbjct: 253 LDCWQKERSDRPKFGQI 269 >2BRG-A nrPDB Length = 297 Score = 207 bits (526), Expect = 9e-54, Method: Composition-based stats. Identities = 70/310 (22%), Positives = 122/310 (39%), Gaps = 54/310 (17%) Query: 20 IHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVN 79 + ++ +G GA G V A + +T++ VA+K + + V + +E + K++N Sbjct: 5 FVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVD-MKRAVDCPENIKKEICINKMLN 63 Query: 80 HKNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN-LCQVIQMD--LDHDRMSYLLYQMLCG 136 H+N++ + E YL +E L I+ D + +Q++ G Sbjct: 64 HENVVKFYG------HRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAG 117 Query: 137 IKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLA---RTAGTTFMMTPYVVTRYYRAPE 193 + +LH GI HRD+KP N+++ LKI DFGLA R ++ T Y APE Sbjct: 118 VVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPE 177 Query: 194 VILGMGY-TENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQP 252 ++ + E VD+WS G ++ M+ G + + Q Sbjct: 178 LLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQ--------------------- 216 Query: 253 TVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVD 312 + D ++ S LL K+LV +P RI++ Sbjct: 217 -------------------EYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIP 257 Query: 313 EALKHEYINV 322 + K + N Sbjct: 258 DIKKDRWYNK 267 >5L6P-A nrPDB Length = 298 Score = 207 bits (526), Expect = 9e-54, Method: Composition-based stats. Identities = 60/259 (23%), Positives = 100/259 (38%), Gaps = 26/259 (10%) Query: 28 RPIGSGAQGIVCAAYDTITQQN---VAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNII 84 IG+G G VC + VAIK L + + E +M +H NII Sbjct: 25 EVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGY-TERQRRDFLSEASIMGQFDHPNII 83 Query: 85 GLLNAFTPQRNLEEFQDVYLVMELMDA----NLCQVIQMDLDHDRMSYLLYQMLCGIKHL 140 L T R V ++ E M+ + ++ ++ +L + G+K+L Sbjct: 84 RLEGVVTKSR------PVMILTEFMENCALDSFLRLNDGQFTVIQLVGMLRGIAAGMKYL 137 Query: 141 HSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYV------VTRYYRAPEV 194 +HRDL NI+V ++ K+ DFGL+R Y + + APE Sbjct: 138 SEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTAPEA 197 Query: 195 ILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQWNKIIEQLGTPSP-----SFMQ 248 I +T D+WS G +M E++ G + + D N + + P P + Q Sbjct: 198 IAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVEQDYRLPPPMDCPTALHQ 257 Query: 249 RLQPTVRNYVENRPRYTGY 267 + RP+++ Sbjct: 258 LMLDCWVRDRNLRPKFSQI 276 >3QA8-A nrPDB Length = 676 Score = 207 bits (526), Expect = 9e-54, Method: Composition-based stats. Identities = 64/241 (26%), Positives = 101/241 (41%), Gaps = 10/241 (4%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNI 83 + +G+G G V T + VAIK+ + + + +R E ++MK +NH N+ Sbjct: 16 WEMKERLGTGGFGYVLRWIHQDTGEQVAIKQCRQEL-SPKNRERWCLEIQIMKKLNHPNV 74 Query: 84 IGLLNAFTPQRNLEEFQDVYLVMELMDA-NLCQVIQM-----DLDHDRMSYLLYQMLCGI 137 + + L L ME + +L + + L + LL + + Sbjct: 75 VSAREVPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGPIRTLLSDISSAL 134 Query: 138 KHLHSAGIIHRDLKPSNIVVKADCT---LKILDFGLARTAGTTFMMTPYVVTRYYRAPEV 194 ++LH IIHRDLKP NIV++ KI+D G A+ + T +V T Y APE+ Sbjct: 135 RYLHENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQGELCTEFVGTLQYLAPEL 194 Query: 195 ILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTV 254 + YT VD WS G + E I G F QW+ + + L V Sbjct: 195 LEQKKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHGKVREKSNEHIVVYDDLTGAV 254 Query: 255 R 255 + Sbjct: 255 K 255 >3FME-A nrPDB Length = 290 Score = 206 bits (525), Expect = 1e-53, Method: Composition-based stats. Identities = 67/315 (21%), Positives = 127/315 (40%), Gaps = 60/315 (19%) Query: 29 PIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKL-MKLVNHKNIIGLL 87 +G GA G+V + Q +A+K++ R N KR + + M+ V+ + Sbjct: 14 ELGRGAYGVVEKMRHVPSGQIMAVKRI-RATVNSQEQKRLLMDLDISMRTVDCPFTVTFY 72 Query: 88 NAFTPQRNLEEFQDVYLVMELMDANLCQVIQM------DLDHDRMSYLLYQMLCGIKHLH 141 A L DV++ MELMD +L + + + D + + ++ ++HLH Sbjct: 73 GA------LFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLH 126 Query: 142 SA-GIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVI----L 196 S +IHRD+KPSN+++ A +K+ DFG++ + Y APE I Sbjct: 127 SKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDDVAKDIDAGCKPYMAPERINPELN 186 Query: 197 GMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRN 256 GY+ DIWS+G M E+ + FP + ++ + + PSP Sbjct: 187 QKGYSVKSDIWSLGITMIELAI--LRFPYDSWGTPFQQLKQVVEEPSPQLPAD------- 237 Query: 257 YVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALK 316 + +++ + S+ L + ++R + E ++ Sbjct: 238 -------------------------------KFSAEFVDFTSQCLKKNSKERPTYPELMQ 266 Query: 317 HEYINVWYDAEEVDA 331 H + ++++ D Sbjct: 267 HPFFT-LHESKGTDV 280 >4UYA-A nrPDB Length = 340 Score = 206 bits (525), Expect = 1e-53, Method: Composition-based stats. Identities = 77/302 (25%), Positives = 119/302 (39%), Gaps = 31/302 (10%) Query: 22 SRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQN--VTHAKRAYREFKLMKLVN 79 R IG+G G V A Q VA+K + + A+ RE +L ++ Sbjct: 26 ERLELKELIGAGGFGQVYRATWQ--GQEVAVKAARQDPEQDAAAAAESVRREARLFAMLR 83 Query: 80 HKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQ--VIQMDLDHDRMSYLLYQMLCGI 137 H NII L Q +L LV+E + + + Q+ G+ Sbjct: 84 HPNIIELRGVCLQQPHL------CLVLEFARGGALNRALAGRRIPPHVLVNWAVQIARGM 137 Query: 138 KHLHSAG---IIHRDLKPSNIVVKA--------DCTLKILDFGLARTAGTTFMMTPYVVT 186 +LH I+HRDLK SNI++ + TLKI DFGLAR T M Sbjct: 138 LYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTKMAT-AGA 196 Query: 187 RYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQ-WNKIIEQLGTPSP- 244 + APEVI +++ DIWS G ++ E++ G V + G D + + + +L P P Sbjct: 197 YAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLTLPIPS 256 Query: 245 ----SFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNL-LSK 299 F + ++ + RP + +G + Q S D L + + Sbjct: 257 TCPEPFAKLMKECWQQDPHIRPSFALILEQLTAIEGAVMTEMPQESFHSMQDDWKLEIQQ 316 Query: 300 ML 301 M Sbjct: 317 MF 318 >2H8H-A nrPDB Length = 535 Score = 206 bits (525), Expect = 1e-53, Method: Composition-based stats. Identities = 61/278 (21%), Positives = 109/278 (39%), Gaps = 29/278 (10%) Query: 2 TTAQHQHYTVEVGDTNFTIHSRYINLR-PIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQ 60 + Q Q + + I + L +G G G V T VAIK L Sbjct: 250 SKPQTQGLAKD----AWEIPRESLRLEVKLGQGCFGEVWMGTWNGT-TRVAIKTLKP--- 301 Query: 61 NVTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELM-DANLCQVIQM 119 + +E ++MK + H+ ++ L + + +Y+V E M +L ++ Sbjct: 302 GTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEE-------PIYIVTEYMSKGSLLDFLKG 354 Query: 120 D----LDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAG 175 + L ++ + Q+ G+ ++ +HRDL+ +NI+V + K+ DFGLAR Sbjct: 355 ETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIE 414 Query: 176 TTFM--MTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQW 232 + APE L +T D+WS G ++ E+ G V +PG + + Sbjct: 415 DNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVL 474 Query: 233 NKIIEQLGTPSPS-----FMQRLQPTVRNYVENRPRYT 265 +++ P P + R E RP + Sbjct: 475 DQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFE 512 >6F3F-A nrPDB Length = 455 Score = 206 bits (524), Expect = 1e-53, Method: Composition-based stats. Identities = 61/278 (21%), Positives = 110/278 (39%), Gaps = 29/278 (10%) Query: 2 TTAQHQHYTVEVGDTNFTIHSRYINLR-PIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQ 60 + Q Q + + I + L +G G G V T VAIK L Sbjct: 170 SKPQTQGLAKD----AWEIPRESLRLEVKLGQGCFGEVWMGTWNGT-TRVAIKTLKP--- 221 Query: 61 NVTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQM 119 + +E ++MK + H+ ++ L + + +Y+V E M+ +L ++ Sbjct: 222 GTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEE-------PIYIVTEYMNKGSLLDFLKG 274 Query: 120 D----LDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAG 175 + L ++ + Q+ G+ ++ +HRDL+ +NI+V + K+ DFGLAR Sbjct: 275 ETGKYLRLPQLVDMSAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIE 334 Query: 176 TTFM--MTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQW 232 + APE L +T D+WS G ++ E+ G V +PG + + Sbjct: 335 DNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVL 394 Query: 233 NKIIEQLGTPSPS-----FMQRLQPTVRNYVENRPRYT 265 +++ P P + R E RP + Sbjct: 395 DQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFE 432 >1TKI-A nrPDB Length = 321 Score = 206 bits (523), Expect = 2e-53, Method: Composition-based stats. Identities = 59/310 (19%), Positives = 125/310 (40%), Gaps = 54/310 (17%) Query: 19 TIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLV 78 ++ +Y+ +G G GIV +T +++ K + T +E ++ + Sbjct: 2 ELYEKYMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVK---VKGTDQVLVKKEISILNIA 58 Query: 79 NHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDA-NLCQVIQM---DLDHDRMSYLLYQML 134 H+NI+ L +F E +++ ++ E + ++ + I +L+ + ++Q+ Sbjct: 59 RHRNILHLHESF------ESMEELVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVC 112 Query: 135 CGIKHLHSAGIIHRDLKPSNIVV--KADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAP 192 ++ LHS I H D++P NI+ + T+KI++FG AR Y AP Sbjct: 113 EALQFLHSHNIGHFDIRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLFTAPEYYAP 172 Query: 193 EVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQP 252 EV + D+WS+G ++ ++ G F + I+ Sbjct: 173 EVHQHDVVSTATDMWSLGTLVYVLLSGINPFLAETNQQIIENIMN--------------- 217 Query: 253 TVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVD 312 Y+FD + + + +A + + ++LV + + R++ Sbjct: 218 ------------AEYTFDE------------EAFKEISIEAMDFVDRLLVKERKSRMTAS 253 Query: 313 EALKHEYINV 322 EAL+H ++ Sbjct: 254 EALQHPWLKQ 263 >2R2P-A nrPDB Length = 295 Score = 206 bits (523), Expect = 2e-53, Method: Composition-based stats. Identities = 61/260 (23%), Positives = 102/260 (39%), Gaps = 24/260 (9%) Query: 25 INLRPIGSGAQGIVCAAYDTITQQN---VAIKKLSRPFQNVTHAKRAYREFKLMKLVNHK 81 R IG+G G VC+ + + VAIK L + + E +M +H Sbjct: 25 TIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGY-TEKQRRDFLGEASIMGQFDHP 83 Query: 82 NIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMD----LDHDRMSYLLYQMLCGI 137 NII L T + V +V E M+ ++ +L + G+ Sbjct: 84 NIIHLEGVVTKSK------PVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGISAGM 137 Query: 138 KHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTT----FMMTPYVVTRYYRAPE 193 K+L G +HRDL NI++ ++ K+ DFGL+R + + + APE Sbjct: 138 KYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPE 197 Query: 194 VILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQWNKIIEQLGTPSP-----SFM 247 I +T D+WS G +M E++ G + + D + E PSP + Sbjct: 198 AIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPAALY 257 Query: 248 QRLQPTVRNYVENRPRYTGY 267 Q + + +RP++ Sbjct: 258 QLMLDCWQKERNSRPKFDEI 277 >4E93-A nrPDB Length = 377 Score = 206 bits (523), Expect = 2e-53, Method: Composition-based stats. Identities = 59/258 (22%), Positives = 101/258 (39%), Gaps = 20/258 (7%) Query: 21 HSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNH 80 H + IG G G V + VA+K R + +E +++K +H Sbjct: 113 HEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSC-RETLPPDLKAKFLQEARILKQYSH 171 Query: 81 KNIIGLLNAFTPQRNLEEFQDVYLVMELM-DANLCQVIQMDLDHDRMSYLLYQM---LCG 136 NI+ L+ T + Q +Y+VMEL+ + ++ + R+ LL + G Sbjct: 172 PNIVRLIGVCTQK------QPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAG 225 Query: 137 IKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTP---YVVTRYYRAPE 193 +++L S IHRDL N +V LKI DFG++R V + APE Sbjct: 226 MEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPE 285 Query: 194 VILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQWNKIIEQLGTPSPSF-----M 247 + Y+ D+WS G ++ E G +P + + + P P Sbjct: 286 ALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVF 345 Query: 248 QRLQPTVRNYVENRPRYT 265 + ++ RP ++ Sbjct: 346 RLMEQCWAYEPGQRPSFS 363 >5X5O-A nrPDB Length = 310 Score = 205 bits (522), Expect = 2e-53, Method: Composition-based stats. Identities = 76/297 (25%), Positives = 121/297 (40%), Gaps = 42/297 (14%) Query: 31 GSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNAF 90 G G+ G V A + VA+KKL + +E +++ +++H+NII Sbjct: 24 GGGSFGSVYRAKWISQDKEVAVKKLLK----------IEKEAEILSVLSHRNIIQFYGVI 73 Query: 91 TPQRNLEEFQDVYLVMELMD-ANLCQVIQM----DLDHDRMSYLLYQMLCGIKHLHSA-- 143 N +V E +L I ++D D + + G+ +LH Sbjct: 74 LEPPN------YGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAP 127 Query: 144 -GIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGYTE 202 +IHRDLK N+V+ AD LKI DFG +R T M V T + APEVI + +E Sbjct: 128 VKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHM-SLVGTFPWMAPEVIQSLPVSE 186 Query: 203 NVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQ------LGTPSPSFMQRLQPTVRN 256 D +S G ++ EM+ V F G + + ++E+ + SF + L Sbjct: 187 TCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEA 246 Query: 257 YVENRPRYTG-------YSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKM--LVID 304 + RP + S D PD +N+ R +A L ++ L D Sbjct: 247 DAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEAT--LERLKKLERD 301 >6CCF-A nrPDB Length = 290 Score = 205 bits (521), Expect = 3e-53, Method: Composition-based stats. Identities = 69/330 (20%), Positives = 130/330 (39%), Gaps = 75/330 (22%) Query: 23 RYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSR------------------------P 58 +Y IG GA G+V AY+ ++ A+K LS+ P Sbjct: 6 QYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGGP 65 Query: 59 FQNVTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQ 118 + + +R Y+E ++K ++H N++ L+ ++YLV +L+ + Sbjct: 66 AKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAE----DNLYLVFDLLRKGPVMEVP 121 Query: 119 --MDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLA-RTAG 175 ++ L ++ G+++LH I+HRD+KPSN+++ D +KI DFG++ + G Sbjct: 122 CDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEG 181 Query: 176 TTFMMTPYVVTRYYRAPEVILGMGYT---ENVDIWSVGCIMGEMIRGGVLFPGTDHIDQW 232 ++ T + APE I G + + +D+W+ G + + G F Sbjct: 182 NDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDD------ 235 Query: 233 NKIIEQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASD 292 F+ L ++N P + + Sbjct: 236 -------------FILALHRKIKNEPVVFPEEP----------------------EISEE 260 Query: 293 ARNLLSKMLVIDPEQRISVDEALKHEYINV 322 ++L+ KML +PE RI V + H ++ Sbjct: 261 LKDLILKMLDKNPETRIGVPDIKLHPWVTK 290 >2XNP-A nrPDB Length = 279 Score = 205 bits (521), Expect = 3e-53, Method: Composition-based stats. Identities = 66/272 (24%), Positives = 109/272 (40%), Gaps = 17/272 (6%) Query: 22 SRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHK 81 Y L IG+G+ G + + K+L + E L++ + H Sbjct: 6 EDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHP 65 Query: 82 NIIGLLNAFTPQRNLEEFQDVYLVMELMDA-NLCQVI------QMDLDHDRMSYLLYQML 134 NI+ + + N +Y+VME + +L VI + LD + + ++ Q+ Sbjct: 66 NIVRYYDRIIDRTN----TTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLT 121 Query: 135 CGIKHLHS-----AGIIHRDLKPSNIVVKADCTLKILDFGLARTA-GTTFMMTPYVVTRY 188 +K H ++HRDLKP+N+ + +K+ DFGLAR T +V T Y Sbjct: 122 LALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPY 181 Query: 189 YRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQ 248 Y +PE + M Y E DIWS+GC++ E+ F + KI E P Sbjct: 182 YMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYS 241 Query: 249 RLQPTVRNYVENRPRYTGYSFDRLFPDGLFPN 280 + + N Y S + + + L Sbjct: 242 DELNEIITRMLNLKDYHRPSVEEILENPLILE 273 >2VWV-A nrPDB Length = 302 Score = 205 bits (521), Expect = 3e-53, Method: Composition-based stats. Identities = 61/268 (22%), Positives = 96/268 (35%), Gaps = 27/268 (10%) Query: 19 TIHSRYINLR-PIGSGAQGIVCAAYDTITQQN---VAIKKLSRPFQNVTHAKRAYREFKL 74 I Y+ + IG+G G VC + VAIK L + + E + Sbjct: 12 EIDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGY-TERQRREFLSEASI 70 Query: 75 MKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQM----DLDHDRMSYLL 130 M H NII L T V ++ E M+ ++ +L Sbjct: 71 MGQFEHPNIIRLEGVVT------NSMPVMILTEFMENGALDSFLRLNDGQFTVIQLVGML 124 Query: 131 YQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYV------ 184 + G+++L +HRDL NI+V ++ K+ DFGL+R Sbjct: 125 RGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTETSSLGGK 184 Query: 185 VTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQWNKIIEQLGTPS 243 + + APE I +T D WS G +M E++ G + + D N I + P Sbjct: 185 IPIRWTAPEAIAFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPP 244 Query: 244 PS-----FMQRLQPTVRNYVENRPRYTG 266 P Q + + RPR+ Sbjct: 245 PPDCPTSLHQLMLDCWQKDRNARPRFPQ 272 >3DKO-A nrPDB Length = 318 Score = 205 bits (521), Expect = 3e-53, Method: Composition-based stats. Identities = 61/257 (23%), Positives = 103/257 (40%), Gaps = 24/257 (9%) Query: 28 RPIGSGAQGIVCAAYDTITQQN---VAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNII 84 R IG+G G VC+ + + VAIK L + + E +M +H N++ Sbjct: 49 RVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGY-TEKQRRDFLCEASIMGQFDHPNVV 107 Query: 85 GLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHD----RMSYLLYQMLCGIKHL 140 L T + V +V+E M+ D ++ +L + G+++L Sbjct: 108 HLEGVVTRGK------PVMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGMRYL 161 Query: 141 HSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTT----FMMTPYVVTRYYRAPEVIL 196 G +HRDL NI+V ++ K+ DFGL+R + T + + APE I Sbjct: 162 ADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQ 221 Query: 197 GMGYTENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQWNKIIEQLGTPSP-----SFMQRL 250 +T D+WS G +M E++ G + + D I E P+P Q + Sbjct: 222 YRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPAPMDCPAGLHQLM 281 Query: 251 QPTVRNYVENRPRYTGY 267 + RP++ Sbjct: 282 LDCWQKERAERPKFEQI 298 >4OLI-A nrPDB Length = 645 Score = 204 bits (519), Expect = 5e-53, Method: Composition-based stats. Identities = 62/325 (19%), Positives = 116/325 (35%), Gaps = 45/325 (13%) Query: 20 IHSRYIN-LRPIGSGAQGIVCA-AYDTI---TQQNVAIKKLSRPFQNVTHAKRAYREFKL 74 H RY+ +R +G G G V YD T + VA+K L + H +E + Sbjct: 350 FHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKAL-KADCGPQHRSGWKQEIDI 408 Query: 75 MKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVI-QMDLDHDRMSYLLYQ 132 ++ + H++II Q + + LVME + +L + + + ++ Q Sbjct: 409 LRTLYHEHIIKYKGCCEDQGE----KSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQ 464 Query: 133 MLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYV----VTRY 188 + G+ +LHS IHR+L N+++ D +KI DFGLA+ + Sbjct: 465 ICEGMAYLHSQHYIHRNLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVF 524 Query: 189 YRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQ 248 + APE + + D+WS G + E++ K +E +G Sbjct: 525 WYAPECLKEYKFYYASDVWSFGVTLYELLTHC-----DSSQSPPTKFLELIGIAQGQMTV 579 Query: 249 RLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQR 308 + E PR + +L+ + R Sbjct: 580 LRLTELLERGERLPRPDKCPC----------------------EVYHLMKNCWETEASFR 617 Query: 309 ISVDEALKHEYINVWYDAEEVDAPA 333 + + + + ++ + AP+ Sbjct: 618 PTFENLI--PILKTVHEKYQGQAPS 640 Score = 88.1 bits (217), Expect = 6e-18, Method: Composition-based stats. Identities = 37/242 (15%), Positives = 77/242 (31%), Gaps = 28/242 (11%) Query: 41 AYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQ 100 D + V +K L ++ A Y LM V+H ++ + Sbjct: 88 GRDRGQELRVVLKVLDPSHHDIALA--FYETASLMSQVSHTHLAFVHGVCVRGP------ 139 Query: 101 DVYLVMELMDANLCQVI----QMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIV 156 + +V E ++ V + + + Q+ + +L + ++H ++ NI+ Sbjct: 140 ENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNIL 199 Query: 157 VKADCT-------LKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILG--MGYTENVDIW 207 + +K+ D G+ A V + APE + G + +D W Sbjct: 200 LARLGLAEGTSPFIKLSDPGVGLGA---LSREERVERIPWLAPECLPGGANSLSTAMDKW 256 Query: 208 SVGCIMGEM-IRGGVLFP--GTDHIDQWNKIIEQLGTP-SPSFMQRLQPTVRNYVENRPR 263 G + E+ G + + + +L P P + RP Sbjct: 257 GFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPS 316 Query: 264 YT 265 + Sbjct: 317 FR 318 >3ORP-A nrPDB Length = 311 Score = 204 bits (519), Expect = 5e-53, Method: Composition-based stats. Identities = 60/252 (23%), Positives = 107/252 (42%), Gaps = 10/252 (3%) Query: 15 DTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPF-QNVTHAKRAYREFK 73 T + RY +G G V A D ++VA+K L ++ + R RE + Sbjct: 5 TTPSHLSDRYELGEILGFGGMSEVHLARDLRDHRDVAVKVLRADLARDPSFYLRFRREAQ 64 Query: 74 LMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVI---QMDLDHDRMSYLL 130 +NH I+ + + T + Y+VME +D + I + + R ++ Sbjct: 65 NAAALNHPAIVAVYD--TGEAETPAGPLPYIVMEYVDGVTLRDIVHTEGPMTPKRAIEVI 122 Query: 131 YQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTP----YVVT 186 + H GIIHRD+KP+NI++ A +K++DFG+AR + + T Sbjct: 123 ADACQALNFSHQNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGT 182 Query: 187 RYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSF 246 Y +PE G D++S+GC++ E++ G F G + + + + P + Sbjct: 183 AQYLSPEQARGDSVDARSDVYSLGCVLYEVLTGEPPFTGDSPVSVAYQHVREDPIPPSAR 242 Query: 247 MQRLQPTVRNYV 258 + L + V Sbjct: 243 HEGLSADLDAVV 254 >4FR4-A nrPDB Length = 384 Score = 204 bits (519), Expect = 5e-53, Method: Composition-based stats. Identities = 71/354 (20%), Positives = 134/354 (37%), Gaps = 62/354 (17%) Query: 13 VGDTNFTIH-SRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSR-PFQNVTHAKRAYR 70 V D N ++ + LR IG G+ G VC T++ A+K +++ + ++ Sbjct: 5 VFDENEDVNFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFK 64 Query: 71 EFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQM--DLDHDRMSY 128 E ++M+ + H ++ L +F + ++ D+ L+ +L +Q + + Sbjct: 65 ELQIMQGLEHPFLVNLWYSFQDEEDMFMVVDL-----LLGGDLRYHLQQNVHFKEETVKL 119 Query: 129 LLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRY 188 + +++ + +L + IIHRD+KP NI++ + I DF +A +T T+ Sbjct: 120 FICELVMALDYLQNQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQITTMAGTKP 179 Query: 189 YRAPEVIL---GMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPS 245 Y APE+ G GY+ VD WS+G E++RG + T S Sbjct: 180 YMAPEMFSSRKGAGYSFAVDWWSLGVTAYELLRGRRPYHIRSS------------TSSKE 227 Query: 246 FMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDP 305 + + TV Y + + +LL K+L +P Sbjct: 228 IVHTFETTVVTYPSAW----------------------------SQEMVSLLKKLLEPNP 259 Query: 306 EQRIS-VDEALKHEY---------INVWYDAEEVDAPAPEPYDHSVDEREHTVE 349 +QR S + + Y + D + + E +E Sbjct: 260 DQRFSQLSDVQNFPYMNDINWDAVFQKRLIPGFIPNKGRLNCDPTFELEEMILE 313 >5B2L-A nrPDB Length = 324 Score = 203 bits (517), Expect = 9e-53, Method: Composition-based stats. Identities = 69/335 (20%), Positives = 122/335 (36%), Gaps = 64/335 (19%) Query: 3 TAQHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNV 62 T Q Y E+ D NL +GSG G V T +A+K++ R N Sbjct: 6 TIGGQRYQAEINDL--------ENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRS-GNK 56 Query: 63 THAKRAYREFKL-MKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN---LCQVIQ 118 KR + + +K + I+ F DV++ MELM + L + +Q Sbjct: 57 EENKRILMDLDVVLKSHDCPYIVQCFGTFITN------TDVFIAMELMGTSAEKLKKRMQ 110 Query: 119 MDLDHDRMSYLLYQMLCGIKHL-HSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTT 177 + + + ++ + +L G+IHRD+KPSNI++ +K+ DFG++ + Sbjct: 111 GPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDS 170 Query: 178 FMMTPYVVTRYYRAPEVI-----LGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQW 232 T Y APE I Y D+WS+G + E+ G + Sbjct: 171 KAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKN------- 223 Query: 233 NKIIEQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASD 292 + + L ++ P + G+ + D Sbjct: 224 ----------CKTDFEVLTKVLQEEPPLLPGHMGF----------------------SGD 251 Query: 293 ARNLLSKMLVIDPEQRISVDEALKHEYINVWYDAE 327 ++ + L D +R ++ L+H +I + E Sbjct: 252 FQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLE 286 >2DQ7-X nrPDB Length = 283 Score = 203 bits (516), Expect = 1e-52, Method: Composition-based stats. Identities = 58/254 (22%), Positives = 102/254 (40%), Gaps = 24/254 (9%) Query: 25 INLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNII 84 ++ +G+G G V VAIK L + E ++MK + H ++ Sbjct: 12 QLIKRLGNGQFGEVWMGTWNG-NTKVAIKTLKP---GTMSPESFLEEAQIMKKLKHDKLV 67 Query: 85 GLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQ----MDLDHDRMSYLLYQMLCGIKH 139 L + + +Y+V E M+ +L ++ L + + Q+ G+ + Sbjct: 68 QLYAVVSEE-------PIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAY 120 Query: 140 LHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFM--MTPYVVTRYYRAPEVILG 197 + IHRDL+ +NI+V KI DFGLAR + APE L Sbjct: 121 IERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALY 180 Query: 198 MGYTENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQWNKIIEQLGTPSP-----SFMQRLQ 251 +T D+WS G ++ E++ G V +PG ++ + ++ P P S + + Sbjct: 181 GRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMI 240 Query: 252 PTVRNYVENRPRYT 265 + E RP + Sbjct: 241 HCWKKDPEERPTFE 254 >3TT0-A nrPDB Length = 382 Score = 202 bits (515), Expect = 2e-52, Method: Composition-based stats. Identities = 72/289 (24%), Positives = 112/289 (38%), Gaps = 44/289 (15%) Query: 15 DTNFTIH-SRYINLRPIGSGAQGIVCAA------YDTITQ-QNVAIKKLSRPFQNVTHAK 66 D + + R + +P+G GA G V A D + VA+K L + Sbjct: 61 DPRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKML-KSDATEKDLS 119 Query: 67 RAYREFKLMKLV-NHKNIIGLLNAFTPQRNLEEFQDVYLVMELM-DANLCQVIQ------ 118 E ++MK++ HKNII LL A T +Y+++E NL + +Q Sbjct: 120 DLISEMEMMKMIGKHKNIINLLGACTQDG------PLYVIVEYASKGNLREYLQARRPPG 173 Query: 119 ------------MDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKIL 166 L + YQ+ G+++L S IHRDL N++V D +KI Sbjct: 174 LEYSYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIA 233 Query: 167 DFGLARTAGT---TFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIR-GGVL 222 DFGLAR T + + APE + YT D+WS G ++ E+ GG Sbjct: 234 DFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSP 293 Query: 223 FPGTDHIDQWNKIIEQLGTPSP-----SFMQRLQPTVRNYVENRPRYTG 266 +PG + + + E P ++ RP + Sbjct: 294 YPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQ 342 >5A46-A nrPDB Length = 386 Score = 202 bits (514), Expect = 2e-52, Method: Composition-based stats. Identities = 71/284 (25%), Positives = 108/284 (38%), Gaps = 34/284 (11%) Query: 15 DTNFTIH-SRYINLRPIGSGAQGIVCAA------YDTITQ-QNVAIKKLSRPFQNVTHAK 66 D + + R + +P+G G G V A D + VA+K L + Sbjct: 32 DPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKML-KSDATEKDLS 90 Query: 67 RAYREFKLMKLV-NHKNIIGLLNAFTPQRNLEEFQDV--------YL------VMELMDA 111 E ++MK++ HKNII LL A T L + YL +E Sbjct: 91 DLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYC-Y 149 Query: 112 NLCQVIQMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLA 171 N + L + YQ+ G+++L S IHRDL N++V D +KI DFGLA Sbjct: 150 NPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLA 209 Query: 172 RTAGT---TFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGTD 227 R T + + APE + YT D+WS G ++ E+ GG +PG Sbjct: 210 RDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVP 269 Query: 228 HIDQWNKIIEQLGTPSP-----SFMQRLQPTVRNYVENRPRYTG 266 + + + E P ++ RP + Sbjct: 270 VEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQ 313 >5SYS-A nrPDB Length = 286 Score = 202 bits (513), Expect = 3e-52, Method: Composition-based stats. Identities = 62/328 (18%), Positives = 118/328 (35%), Gaps = 64/328 (19%) Query: 18 FTIHSRYINLR-PIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMK 76 + I + L +G G G T VAIK L + +E ++MK Sbjct: 13 WEIPRESLRLEVKLGQGCFGECWMGTWNGT-TRVAIKTLKP---GTMSPEAFLQEAQVMK 68 Query: 77 LVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELM-DANLCQVIQMDLDH----DRMSYLLY 131 + H+ ++ L + + +Y+V E M +L ++ ++ ++ + Sbjct: 69 KLRHEKLVQLYAVVSEE-------PIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAA 121 Query: 132 QMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFM--MTPYVVTRYY 189 Q+ G+ ++ +HRDL+ +NI+V + K+ DFGLAR + Sbjct: 122 QIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKW 181 Query: 190 RAPEVILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQWNKIIEQLGTPSPSFMQ 248 APE L +T D+WS G ++ E+ G V +PG + + +++ P P Sbjct: 182 TAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPP--- 238 Query: 249 RLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQR 308 +L+ + DPE+R Sbjct: 239 ---------------------------------------ECPESLHDLMCQCWRKDPEER 259 Query: 309 ISVDEALKHEYINVWYDAEEVDAPAPEP 336 + E L+ ++ ++ + E E Sbjct: 260 PT-FEYLQ-AFLEDYFTSTEPQYQPGEN 285 >4EQM-A nrPDB Length = 294 Score = 202 bits (513), Expect = 3e-52, Method: Composition-based stats. Identities = 74/225 (32%), Positives = 109/225 (48%), Gaps = 12/225 (5%) Query: 19 TIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHA-KRAYREFKLMKL 77 I+ RY + +G G V A DTI VAIK + P + KR RE Sbjct: 8 IINERYKIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETLKRFEREVHNSSQ 67 Query: 78 VNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDA-NLCQVIQMD--LDHDRMSYLLYQML 134 ++H+NI+ +++ EE YLVME ++ L + I+ L D Q+L Sbjct: 68 LSHQNIVSMIDV------DEEDDCYYLVMEYIEGPTLSEYIESHGPLSVDTAINFTNQIL 121 Query: 135 CGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTP--YVVTRYYRAP 192 GIKH H I+HRD+KP NI++ ++ TLKI DFG+A+ T + + T Y +P Sbjct: 122 DGIKHAHDMRIVHRDIKPQNILIDSNKTLKIFDFGIAKALSETSLTQTNHVLGTVQYFSP 181 Query: 193 EVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIE 237 E G E DI+S+G ++ EM+ G F G + K I+ Sbjct: 182 EQAKGEATDECTDIYSIGIVLYEMLVGEPPFNGETAVSIAIKHIQ 226 >6DBM-A nrPDB Length = 318 Score = 202 bits (513), Expect = 3e-52, Method: Composition-based stats. Identities = 62/325 (19%), Positives = 115/325 (35%), Gaps = 45/325 (13%) Query: 20 IHSRYIN-LRPIGSGAQGIVCA-AYDTI---TQQNVAIKKLSRPFQNVTHAKRAYREFKL 74 H RY+ +R +G G G V YD T + VA+K L + H +E + Sbjct: 28 FHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKAL-KADAGPQHRSGWKQEIDI 86 Query: 75 MKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVI-QMDLDHDRMSYLLYQ 132 ++ + H++II + LVME + +L + + + ++ Q Sbjct: 87 LRTLYHEHIIKYKGCCEDAG----AASLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQ 142 Query: 133 MLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYV----VTRY 188 + G+ +LHS IHRDL N+++ D +KI DFGLA+ + Sbjct: 143 ICEGMAYLHSQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVF 202 Query: 189 YRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQ 248 + APE + + D+WS G + E++ K +E +G Sbjct: 203 WYAPECLKEYKFYYASDVWSFGVTLYELLTHC-----DSSQSPPTKFLELIGIAQGQMTV 257 Query: 249 RLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQR 308 + E PR ++ +L+ + R Sbjct: 258 LRLTELLERGERLPRPDKCP----------------------AEVYHLMKNCWETEASFR 295 Query: 309 ISVDEALKHEYINVWYDAEEVDAPA 333 + + + + ++ + AP+ Sbjct: 296 PTFENLI--PILKTVHEKYQGQAPS 318 >4YHJ-A nrPDB Length = 584 Score = 201 bits (512), Expect = 3e-52, Method: Composition-based stats. Identities = 71/332 (21%), Positives = 128/332 (38%), Gaps = 59/332 (17%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKR-AYREFKLMKLVNHKN 82 + + R +G G G VCA T + A KKL + + A E ++++ V + Sbjct: 187 FRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQSRF 246 Query: 83 IIGLLNAFTPQRNLEEFQDVYLVMELMDAN-----LCQVIQMDLDHDRMSYLLYQMLCGI 137 ++ L A+ + L LV+ +M+ + + D R + ++ CG+ Sbjct: 247 VVSLAYAYETKDAL------CLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGL 300 Query: 138 KHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILG 197 + L I++RDLKP NI++ ++I D GLA + V T Y APEV+ Sbjct: 301 EDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNN 360 Query: 198 MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNY 257 YT + D W +GC++ EMI+G F +W ++ +++ Sbjct: 361 EKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRI------------------ 402 Query: 258 VENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRI-----SVD 312 ND + S + + DA+++ +L +P +R+ Sbjct: 403 ---------------------KNDTEEYSEKFSEDAKSICRMLLTKNPSKRLGCRGEGAA 441 Query: 313 EALKHEYINV---WYDAEEVDAPAPEPYDHSV 341 +H + P P H+V Sbjct: 442 GVKQHPVFKDINFRRLEANMLEPPFCPDPHAV 473 >3GQL-A nrPDB Length = 326 Score = 201 bits (511), Expect = 5e-52, Method: Composition-based stats. Identities = 72/284 (25%), Positives = 109/284 (38%), Gaps = 34/284 (11%) Query: 15 DTNFTIH-SRYINLRPIGSGAQGIVCAA------YDTITQ-QNVAIKKLSRPFQNVTHAK 66 D + + R + +P+G GA G V A D + VA+K L + Sbjct: 20 DPRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKML-KSDATEKDLS 78 Query: 67 RAYREFKLMKLV-NHKNIIGLLNAFTPQRNLEEFQDV--------YL------VMELMDA 111 E ++MK++ HKNII LL A T L + YL +E Sbjct: 79 DLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYC-Y 137 Query: 112 NLCQVIQMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLA 171 N + L + YQ+ G+++L S IHRDL N++V D +KI DFGLA Sbjct: 138 NPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLA 197 Query: 172 RTAGT---TFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGTD 227 R T + + APE + YT D+WS G ++ E+ GG +PG Sbjct: 198 RDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVP 257 Query: 228 HIDQWNKIIEQLGTPSP-----SFMQRLQPTVRNYVENRPRYTG 266 + + + E P ++ RP + Sbjct: 258 VEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQ 301 >2PSQ-A nrPDB Length = 370 Score = 199 bits (507), Expect = 1e-51, Method: Composition-based stats. Identities = 70/284 (24%), Positives = 109/284 (38%), Gaps = 34/284 (11%) Query: 15 DTNFTIH-SRYINLRPIGSGAQGIVCAA----YDTITQQN---VAIKKLSRPFQNVTHAK 66 D + + +P+G G G V A D + VA+K L + Sbjct: 73 DPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKML-KDDATEKDLS 131 Query: 67 RAYREFKLMKLV-NHKNIIGLLNAFTPQRNLEEFQDV--------YL------VMELMDA 111 E ++MK++ HKNII LL A T L + YL ME Sbjct: 132 DLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEY-SY 190 Query: 112 NLCQVIQMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLA 171 ++ +V + + + YQ+ G+++L S IHRDL N++V + +KI DFGLA Sbjct: 191 DINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLA 250 Query: 172 RTAGT---TFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGTD 227 R T + + APE + YT D+WS G +M E+ GG +PG Sbjct: 251 RDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIP 310 Query: 228 HIDQWNKIIEQLGTPSP-----SFMQRLQPTVRNYVENRPRYTG 266 + + + E P ++ RP + Sbjct: 311 VEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQ 354 >5TQX-A nrPDB Length = 655 Score = 199 bits (507), Expect = 1e-51, Method: Composition-based stats. Identities = 78/322 (24%), Positives = 120/322 (37%), Gaps = 40/322 (12%) Query: 15 DTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKL 74 D F + +G+G G VC +AIK + + +R E ++ Sbjct: 1 DPEFGAGGPWEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLEL-STKNRERWCHEIQI 59 Query: 75 MKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMD------LDHDRMSY 128 MK +NH N++ + L + L ME + + L ++ Sbjct: 60 MKKLNHANVVKACDVPEELNILIHDVPL-LAMEYCSGGDLRKLLNKPENCCGLKESQILS 118 Query: 129 LLYQMLCGIKHLHSAGIIHRDLKPSNIVV-KADCTL--KILDFGLARTAGTTFMMTPYVV 185 LL + GI++LH IIHRDLKP NIV+ + KI+D G A+ + T +V Sbjct: 119 LLSDIGSGIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGELCTEFVG 178 Query: 186 TRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPS 245 T Y APE+ YT VD WS G ++ E I G F W++ I++ Sbjct: 179 TLQYLAPELFENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPKCIF 238 Query: 246 FMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDP 305 + + VR F P N N L ML DP Sbjct: 239 ACEEMSGEVR-------------FSSHLP------QPNSLCSLIVEPMENWLQLMLNWDP 279 Query: 306 EQR-----ISVDE-----ALKH 317 +QR +++ + + H Sbjct: 280 QQRGGPVDLTLKQPRCFVLMDH 301 >3A4O-X nrPDB Length = 286 Score = 199 bits (506), Expect = 2e-51, Method: Composition-based stats. Identities = 56/254 (22%), Positives = 101/254 (39%), Gaps = 23/254 (9%) Query: 25 INLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNII 84 ++ +G+G G V Y + VA+K L + E LMK + H ++ Sbjct: 16 KLVKRLGAGQFGEVWMGYYNNS-TKVAVKTLKP---GTMSVQAFLEEANLMKTLQHDKLV 71 Query: 85 GLLNAFTPQRNLEEFQDVYLVMELM-DANLCQVIQMD----LDHDRMSYLLYQMLCGIKH 139 L T + + +Y++ E M +L ++ D + ++ Q+ G+ + Sbjct: 72 RLYAVVTRE------EPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAY 125 Query: 140 LHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFM--MTPYVVTRYYRAPEVILG 197 + IHRDL+ +N++V KI DFGLAR + APE I Sbjct: 126 IERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINF 185 Query: 198 MGYTENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQWNKIIEQLGTP-----SPSFMQRLQ 251 +T D+WS G ++ E++ G + +PG + D + + P ++ Sbjct: 186 GCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMK 245 Query: 252 PTVRNYVENRPRYT 265 + E RP + Sbjct: 246 MCWKEKAEERPTFD 259 >4XCU-A nrPDB Length = 300 Score = 199 bits (506), Expect = 2e-51, Method: Composition-based stats. Identities = 66/273 (24%), Positives = 109/273 (39%), Gaps = 34/273 (12%) Query: 21 HSRYINLRPIGSGAQGIVCAAY-------DTITQQNVAIKKLSRPFQNVTHAKRAYREFK 73 R + +P+G G G V A VA+K L + + E + Sbjct: 16 RDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKML-KDNASDKDLADLVSEME 74 Query: 74 LMKLV-NHKNIIGLLNAFTPQRNLEEFQDVYLVMELM-DANLCQVIQMD---------LD 122 +MKL+ HKNII LL T + +Y+++E NL + ++ L Sbjct: 75 VMKLIGRHKNIINLLGVCTQEG------PLYVIVECAAKGNLREFLRARRPPGSSEGPLS 128 Query: 123 HDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGT-TFMMT 181 + YQ+ G+++L S IHRDL N++V D +KI DFGLAR + Sbjct: 129 FPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKK 188 Query: 182 PYVV--TRYYRAPEVILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQWNKI--- 235 + APE + YT D+WS G ++ E+ GG +PG + ++ + Sbjct: 189 TSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREG 248 Query: 236 --IEQLGTPSPSFMQRLQPTVRNYVENRPRYTG 266 +++ P ++ RP + Sbjct: 249 HRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQ 281 >4AT3-A nrPDB Length = 299 Score = 199 bits (505), Expect = 2e-51, Method: Composition-based stats. Identities = 56/270 (20%), Positives = 106/270 (39%), Gaps = 38/270 (14%) Query: 28 RPIGSGAQGIVCA--AYDT---ITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKN 82 R +G GA G V Y+ + VA+K L N K +RE +L+ + H++ Sbjct: 19 RELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNA--RKDFHREAELLTNLQHEH 76 Query: 83 IIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQ---------------MDLDHDRM 126 I+ E + +V E M +L + ++ +L +M Sbjct: 77 IVKFYGVCV------EGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQM 130 Query: 127 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMT---PY 183 ++ Q+ G+ +L S +HRDL N +V + +KI DFG++R +T Sbjct: 131 LHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHT 190 Query: 184 VVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQWNKI-----IE 237 ++ + PE I+ +T D+WS+G ++ E+ G + + + I ++ Sbjct: 191 MLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQ 250 Query: 238 QLGTPSPSFMQRLQPTVRNYVENRPRYTGY 267 + T + + + R G Sbjct: 251 RPRTCPQEVYELMLGCWQREPHMRKNIKGI 280 >4PWN-A nrPDB Length = 274 Score = 198 bits (504), Expect = 3e-51, Method: Composition-based stats. Identities = 64/309 (20%), Positives = 119/309 (38%), Gaps = 50/309 (16%) Query: 21 HSRYINLR-PIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVN 79 R++ IG G+ V DT T VA +L + +R E +++K + Sbjct: 8 DGRFLKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQ 67 Query: 80 HKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYL---LYQMLCG 136 H NI+ +++ + ++ + + LV ELM + + ++ L Q+L G Sbjct: 68 HPNIVRFYDSW--ESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKG 125 Query: 137 IKHLHSAG--IIHRDLKPSNIVVKAD-CTLKILDFGLARTAGTTFMMTPYVVTRYYRAPE 193 ++ LH+ IIHRDLK NI + ++KI D GLA + T + APE Sbjct: 126 LQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLEKRASFAKSVIGTPEFMAPE 185 Query: 194 VILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPT 253 + Y E+VD+++ G M EM + + Q + + P+ Sbjct: 186 -MYEEKYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPA---------- 234 Query: 254 VRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDE 313 SFD++ + + ++ + + ++R S+ + Sbjct: 235 --------------SFDKV----------------AIPEVKEIIEGCIRQNKDERYSIKD 264 Query: 314 ALKHEYINV 322 L H + Sbjct: 265 LLNHAFFQE 273 >3KUL-B nrPDB Length = 325 Score = 198 bits (504), Expect = 3e-51, Method: Composition-based stats. Identities = 64/263 (24%), Positives = 106/263 (40%), Gaps = 24/263 (9%) Query: 22 SRYINLRPIGSGAQGIVCAAYDTITQQN---VAIKKLSRPFQNVTHAKRAYREFKLMKLV 78 SR + IGSG G VC + Q VAIK L + + E +M Sbjct: 49 SRIHIEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGY-TERQRRDFLSEASIMGQF 107 Query: 79 NHKNIIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQM---DLDHDRMSYLLYQML 134 +H NII L T R +V E M+ +L ++ ++ +L + Sbjct: 108 DHPNIIRLEGVVTRGRL------AMIVTEYMENGSLDTFLRTHDGQFTIMQLVGMLRGVG 161 Query: 135 CGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTT----FMMTPYVVTRYYR 190 G+++L G +HRDL N++V ++ K+ DFGL+R + T + + Sbjct: 162 AGMRYLSDLGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWT 221 Query: 191 APEVILGMGYTENVDIWSVGCIMGE-MIRGGVLFPGTDHIDQWNKIIEQLGTPSP----- 244 APE I ++ D+WS G +M E + G + + D + + E P+P Sbjct: 222 APEAIAFRTFSSASDVWSFGVVMWEVLAYGERPYWNMTNRDVISSVEEGYRLPAPMGCPH 281 Query: 245 SFMQRLQPTVRNYVENRPRYTGY 267 + Q + RPR++ Sbjct: 282 ALHQLMLDCWHKDRAQRPRFSQI 304 >4GS6-A nrPDB Length = 315 Score = 198 bits (503), Expect = 4e-51, Method: Composition-based stats. Identities = 84/352 (23%), Positives = 129/352 (36%), Gaps = 77/352 (21%) Query: 14 GDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFK 73 G + + +G GA G+VC A ++VAIK++ ++ + K E + Sbjct: 1 GSLHMIDYKEIEVEEVVGRGAFGVVCKAKWRA--KDVAIKQI----ESESERKAFIVELR 54 Query: 74 LMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN-LCQVIQMDLD-----HDRMS 127 + VNH NI+ L A V LVME + L V+ Sbjct: 55 QLSRVNHPNIVKLYGACL--------NPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAM 106 Query: 128 YLLYQMLCGIKHLHSAG---IIHRDLKPSNIVVKADCTL-KILDFGLARTAGTTFMMTPY 183 Q G+ +LHS +IHRDLKP N+++ A T+ KI DFG A T MT Sbjct: 107 SWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTH--MTNN 164 Query: 184 VVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPS 243 + + APEV G Y+E D++S G I+ E+I F +++G P+ Sbjct: 165 KGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPF-------------DEIGGPA 211 Query: 244 PSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVI 303 M + + +L+++ Sbjct: 212 FRIM---------------------------WAVHNGTRPPLIKNLPKPIESLMTRCWSK 244 Query: 304 DPEQRISVDE---ALKH--EYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQ 350 DP QR S++E + H Y D P P HS+ E + Sbjct: 245 DPSQRPSMEEIVKIMTHLMRYF------PGADEPLQYPCQHSLPPGEDGRVE 290 >6BXI-A nrPDB Length = 333 Score = 198 bits (503), Expect = 4e-51, Method: Composition-based stats. Identities = 57/277 (20%), Positives = 100/277 (36%), Gaps = 46/277 (16%) Query: 22 SRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRP-FQNVTHAKRAYREFKLMKLVNH 80 + +L+ IG GA G V T A+K L + E ++ + Sbjct: 6 EDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADS 65 Query: 81 KNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVI---QMDLDHDRMSYLLYQMLCGI 137 ++ + +F + NL YL+ME + + + L + + + + + I Sbjct: 66 LWVVKMFYSFQDKLNL------YLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAI 119 Query: 138 KHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPY-------------- 183 +H G IHRD+KP N+++ + +K+ DFGL Y Sbjct: 120 DSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQ 179 Query: 184 ----------------------VVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGV 221 V T Y APEV + GY + D WS+G IM EM+ G Sbjct: 180 NMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYP 239 Query: 222 LFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYV 258 F + + K++ T + + ++ + Sbjct: 240 PFCSETPQETYKKVMNWKETLTFPPEVPISEKAKDLI 276 >4PDO-A nrPDB Length = 299 Score = 197 bits (502), Expect = 5e-51, Method: Composition-based stats. Identities = 56/259 (21%), Positives = 104/259 (40%), Gaps = 25/259 (9%) Query: 25 INLRPIGSGAQGIVCAAYDTIT-QQN---VAIKKLSRPFQNVTHAKRAYREFKLMKLVNH 80 + IG+G G V + + VAIK L + E +M +H Sbjct: 37 TRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGY-TEKQRVDFLGEAGIMGQFSH 95 Query: 81 KNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHD----RMSYLLYQMLCG 136 NII L + ++ + ++ E M+ + D + ++ +L + G Sbjct: 96 HNIIRLEGVISK------YKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAG 149 Query: 137 IKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGT----TFMMTPYVVTRYYRAP 192 +K+L + +HRDL NI+V ++ K+ DFGL+R T+ + + + AP Sbjct: 150 MKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAP 209 Query: 193 EVILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQWNKIIEQLGTPSP-----SF 246 E I +T D+WS G +M E++ G + + + I + P+P + Sbjct: 210 EAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAI 269 Query: 247 MQRLQPTVRNYVENRPRYT 265 Q + + RP++ Sbjct: 270 YQLMMQCWQQERARRPKFA 288 >6GQK-A nrPDB Length = 328 Score = 197 bits (502), Expect = 5e-51, Method: Composition-based stats. Identities = 69/292 (23%), Positives = 109/292 (37%), Gaps = 43/292 (14%) Query: 15 DTNFTIH-SRYINLRPIGSGAQGIVCAA-----YDTITQQNVAIKKLSRPFQNVTHAKRA 68 D + +R + +G+GA G V A + VA+K L +P + T + Sbjct: 33 DHKWEFPRNRLSFGKTLGAGAFGKVVEATAQGLIKSDAAMTVAVKML-KPSAHSTEREAL 91 Query: 69 YREFKLMKLV-NHKNIIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQMDLDH--- 123 E K++ + NH+NI+ LL A T ++ E +L ++ D Sbjct: 92 MSELKVLSYLGNHENIVNLLGACT------HGGPTLVITEYCCYGDLLNFLRRKRDEFVP 145 Query: 124 ---------------DRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDF 168 + + YQ+ G+ L S IHRDL NI++ KI DF Sbjct: 146 YKVAPEDLYKDFLTLEHLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGNITKICDF 205 Query: 169 GLARTAGTTFMMTPY---VVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIR-GGVLFP 224 GLAR + + APE I YT D+WS G + E+ G +P Sbjct: 206 GLARDIKNDSNYVDKGNARLPVKWMAPESIFNSVYTFESDVWSYGIFLWELFSLGSSPYP 265 Query: 225 GTDHIDQWNKII-EQLGTPSPSF-----MQRLQPTVRNYVENRPRYTGYSFD 270 G ++ K+I E SP + ++ + RP + D Sbjct: 266 GMPVDSKFYKMIKEGFRMSSPEYAPAEMYDIMKTCWDADPDKRPTFKQIVQD 317 >5O2B-A nrPDB Length = 285 Score = 197 bits (501), Expect = 6e-51, Method: Composition-based stats. Identities = 65/317 (20%), Positives = 121/317 (38%), Gaps = 51/317 (16%) Query: 11 VEVGDTNFTIHSRYINLR-PIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAY 69 E+ + R++ +G GA V DT T VA +L +R Sbjct: 4 AEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFK 63 Query: 70 REFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELM-DANLCQVIQ--MDLDHDRM 126 E +++K + H NI+ +++ + L+ + + LV ELM L ++ + + Sbjct: 64 EEAEMLKGLQHPNIVRFYDSW--ESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVL 121 Query: 127 SYLLYQMLCGIKHLHSAG--IIHRDLKPSNIVVKAD-CTLKILDFGLARTAGTTFMMTPY 183 Q+L G++ LH+ IIHRDLK NI + ++KI D GLA T+F Sbjct: 122 RSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFA-KSV 180 Query: 184 VVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPS 243 + T + APE + Y E+VD+++ G M EM + + Q + + P+ Sbjct: 181 IGTPEFMAPE-MYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPA 239 Query: 244 PSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVI 303 ++ + + ++ + Sbjct: 240 ----------------------------------------SFNKVTDPEVKEIIEGCIRQ 259 Query: 304 DPEQRISVDEALKHEYI 320 + +R+S+ + L H + Sbjct: 260 NKSERLSIRDLLNHAFF 276 >5EG3-A nrPDB Length = 334 Score = 197 bits (501), Expect = 6e-51, Method: Composition-based stats. Identities = 72/284 (25%), Positives = 110/284 (38%), Gaps = 34/284 (11%) Query: 15 DTNFTIH-SRYINLRPIGSGAQGIVCAA----YDTITQQN---VAIKKLSRPFQNVTHAK 66 D + + +P+G GA G V A D + VA+K L + Sbjct: 27 DPKWEFPRDKLTLGKPLGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKML-KDDATEKDLS 85 Query: 67 RAYREFKLMKLV-NHKNIIGLLNAFTPQRNLEEFQDV--------YL------VMELMDA 111 E ++MK++ HKNII LL A T L YL MEL Sbjct: 86 DLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVAYASKGNLREYLRARRPPGMEL-SP 144 Query: 112 NLCQVIQMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLA 171 ++ +V + + + YQ+ G+++L S IHRDL N++V + +KI DFGLA Sbjct: 145 DINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLA 204 Query: 172 RTAGTT---FMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGTD 227 R T + + APE + YT D+WS G +M E+ GG +PG Sbjct: 205 RDINNIDFFKETTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIP 264 Query: 228 HIDQWNKIIEQLGTPSP-----SFMQRLQPTVRNYVENRPRYTG 266 + + + E P ++ RP + Sbjct: 265 VEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQ 308 >4E20-A nrPDB Length = 290 Score = 197 bits (500), Expect = 8e-51, Method: Composition-based stats. Identities = 51/211 (24%), Positives = 89/211 (42%), Gaps = 16/211 (7%) Query: 20 IHSRYIN-LRPIGSGAQGIVCA-AYDTI---TQQNVAIKKLSRPFQNVTHAKRAYREFKL 74 H RY+ +R +G G G V YD T + VA+K L + RE ++ Sbjct: 5 FHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKAL-KEGCGPQLRSGWQREIEI 63 Query: 75 MKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQMD-LDHDRMSYLLYQ 132 ++ + H++I+ Q + V LVME + +L + + ++ Q Sbjct: 64 LRTLYHEHIVKYKGCCEDQGE----KSVQLVMEYVPLGSLRDYLPRHCVGLAQLLLFAQQ 119 Query: 133 MLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYV----VTRY 188 + G+ +LH+ IHR L N+++ D +KI DFGLA+ + Sbjct: 120 ICEGMAYLHAQHYIHRALAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVF 179 Query: 189 YRAPEVILGMGYTENVDIWSVGCIMGEMIRG 219 + APE + + D+WS G + E++ Sbjct: 180 WYAPECLKECKFYYASDVWSFGVTLYELLTY 210 >4K33-A nrPDB Length = 325 Score = 197 bits (500), Expect = 8e-51, Method: Composition-based stats. Identities = 71/289 (24%), Positives = 113/289 (39%), Gaps = 44/289 (15%) Query: 15 DTNFTI-HSRYINLRPIGSGAQGIVCAA------YDTITQ-QNVAIKKLSRPFQNVTHAK 66 D + + +R +P+G GA G V A D + VA+K L + Sbjct: 28 DPKWELSRARLTLGKPLGEGAFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATD-KDLS 86 Query: 67 RAYREFKLMKLV-NHKNIIGLLNAFTPQRNLEEFQDVYLVMELM-DANLCQVIQ------ 118 E ++MK++ HKNII LL A T +Y+++E NL + ++ Sbjct: 87 DLVSEMEMMKMIGKHKNIINLLGACTQGG------PLYVLVEYAAKGNLREFLRARRPPG 140 Query: 119 ------------MDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKIL 166 L + YQ+ G+++L S IHRDL N++V D +KI Sbjct: 141 LDYSFDTSKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIA 200 Query: 167 DFGLARTAGT---TFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIR-GGVL 222 DFGLAR T + + APE + YT D+WS G ++ E+ GG Sbjct: 201 DFGLARDVHNLDYYKETTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSP 260 Query: 223 FPGTDHIDQWNKIIEQLGTPSPS-----FMQRLQPTVRNYVENRPRYTG 266 +PG + + + E P+ ++ RP + Sbjct: 261 YPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQ 309 >2HK5-A nrPDB Length = 270 Score = 196 bits (499), Expect = 1e-50, Method: Composition-based stats. Identities = 59/252 (23%), Positives = 101/252 (40%), Gaps = 26/252 (10%) Query: 28 RPIGSGAQGIVCAA-YDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGL 86 + +G+G G V A Y+ T+ VA+K + + E +MK + H ++ L Sbjct: 21 KKLGAGQFGEVWMATYNKHTK--VAVKTMKP---GSMSVEAFLAEANVMKTLQHDKLVKL 75 Query: 87 LNAFTPQRNLEEFQDVYLVMELM-DANLCQVIQMDL----DHDRMSYLLYQMLCGIKHLH 141 T + +Y++ E M +L ++ D ++ Q+ G+ + Sbjct: 76 HAVVTKE-------PIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIE 128 Query: 142 SAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFM--MTPYVVTRYYRAPEVILGMG 199 IHRDL+ +NI+V A KI DFGLAR + APE I Sbjct: 129 QRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGS 188 Query: 200 YTENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQWNKIIEQLGTPSP-----SFMQRLQPT 253 +T D+WS G ++ E++ G + +PG + + + P P + Sbjct: 189 FTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRC 248 Query: 254 VRNYVENRPRYT 265 +N E RP + Sbjct: 249 WKNRPEERPTFE 260 >2PL0-A nrPDB Length = 289 Score = 196 bits (498), Expect = 2e-50, Method: Composition-based stats. Identities = 58/254 (22%), Positives = 102/254 (40%), Gaps = 24/254 (9%) Query: 25 INLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNII 84 + +G+G G V Y VA+K L Q E LMK + H+ ++ Sbjct: 26 KLVERLGAGQFGEVWMGYYNG-HTKVAVKSLK---QGSMSPDAFLAEANLMKQLQHQRLV 81 Query: 85 GLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQM----DLDHDRMSYLLYQMLCGIKH 139 L T + +Y++ E M+ +L ++ L +++ + Q+ G+ Sbjct: 82 RLYAVVTQE-------PIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAF 134 Query: 140 LHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFM--MTPYVVTRYYRAPEVILG 197 + IHRDL+ +NI+V + KI DFGLAR + APE I Sbjct: 135 IEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINY 194 Query: 198 MGYTENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQWNKIIEQLGTPSP-----SFMQRLQ 251 +T D+WS G ++ E++ G + +PG + + + P Q ++ Sbjct: 195 GTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMR 254 Query: 252 PTVRNYVENRPRYT 265 + E+RP + Sbjct: 255 LCWKERPEDRPTFD 268 >5O2C-A nrPDB Length = 380 Score = 196 bits (498), Expect = 2e-50, Method: Composition-based stats. Identities = 63/298 (21%), Positives = 115/298 (38%), Gaps = 50/298 (16%) Query: 29 PIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLN 88 +G GA V DT T VA +L +R E +++K + H NI+ + Sbjct: 32 ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYD 91 Query: 89 AFTPQRNLEEFQDVYLVMELM-DANLCQVIQ--MDLDHDRMSYLLYQMLCGIKHLHSAG- 144 ++ + L+ + + LV ELM L ++ + + Q+L G++ LH+ Sbjct: 92 SW--ESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTP 149 Query: 145 -IIHRDLKPSNIVVKAD-CTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGYTE 202 IIHRDLK NI + ++KI D GLA T+F + T + APE + Y E Sbjct: 150 PIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFA-KSVIGTPEFMAPE-MYEEHYDE 207 Query: 203 NVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENRP 262 +VD+++ G M EM + + Q + + P+ Sbjct: 208 SVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPA------------------- 248 Query: 263 RYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEYI 320 ++ + + ++ + + +R+S+ + L H + Sbjct: 249 ---------------------SFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFF 285 >2VD5-A nrPDB Length = 412 Score = 195 bits (497), Expect = 2e-50, Method: Composition-based stats. Identities = 61/349 (17%), Positives = 113/349 (32%), Gaps = 64/349 (18%) Query: 21 HSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSR-PFQNVTHAKRAYREFKLMKLVN 79 + L+ IG GA V T Q A+K +++ E ++ + Sbjct: 60 RDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGD 119 Query: 80 HKNIIGLLNAFTPQRNLEEFQDVYLVMEL-MDANLCQVIQM---DLDHDRMSYLLYQMLC 135 + I L AF + L YLVME + +L ++ + + + L +++ Sbjct: 120 RRWITQLHFAFQDENYL------YLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVM 173 Query: 136 GIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPY--VVTRYYRAPE 193 I +H G +HRD+KP NI++ +++ DFG + V T Y +PE Sbjct: 174 AIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPE 233 Query: 194 VIL-------GMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSF 246 ++ Y D W++G EM G F + + KI+ Sbjct: 234 ILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIV---------- 283 Query: 247 MQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPE 306 +AR+ + ++L PE Sbjct: 284 ----------------------------HYKEHLSLPLVDEGVPEEARDFIQRLLCP-PE 314 Query: 307 QRI---SVDEALKHEYI--NVWYDAEEVDAPAPEPYDHSVDEREHTVEQ 350 R+ + H + W + P ++ + D + + Sbjct: 315 TRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTPDFEGATDTCNFDLVE 363 >5KMM-A nrPDB Length = 329 Score = 195 bits (497), Expect = 2e-50, Method: Composition-based stats. Identities = 58/276 (21%), Positives = 107/276 (38%), Gaps = 41/276 (14%) Query: 19 TIHSRYINLR-PIGSGAQGIVCAAYDT-----ITQQNVAIKKLSRPFQNVTHAKRAYREF 72 I R I L+ +G GA G V A + VA+K L ++ + RE Sbjct: 31 HIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESA--RQDFQREA 88 Query: 73 KLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQMD----------- 120 +L+ ++ H++I+ T E + + +V E M +L + ++ Sbjct: 89 ELLTMLQHQHIVRFFGVCT------EGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGE 142 Query: 121 ------LDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTA 174 L ++ + Q+ G+ +L +HRDL N +V +KI DFG++R Sbjct: 143 DVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDI 202 Query: 175 GTTFMMTPYVVT---RYYRAPEVILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGTDHID 230 +T T + PE IL +T D+WS G ++ E+ G + + + Sbjct: 203 YSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTE 262 Query: 231 QWNKI-----IEQLGTPSPSFMQRLQPTVRNYVENR 261 + I +E+ P ++ + + R Sbjct: 263 AIDCITQGRELERPRACPPEVYAIMRGCWQREPQQR 298 >5U6B-A nrPDB Length = 307 Score = 195 bits (496), Expect = 2e-50, Method: Composition-based stats. Identities = 49/280 (17%), Positives = 98/280 (35%), Gaps = 20/280 (7%) Query: 26 NLRPIGSGAQGIVCAAYDTITQQ--NVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNI 83 + +G G G V VA+K + + + E MK +H N+ Sbjct: 27 LGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNV 86 Query: 84 IGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQMD--------LDHDRMSYLLYQML 134 + L+ E F +++ M +L + L + + + Sbjct: 87 MRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIA 146 Query: 135 CGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVV---TRYYRA 191 G+++L + IHRDL N ++ + ++ + DFGL++ + + A Sbjct: 147 SGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIA 206 Query: 192 PEVILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQWNKIIEQLGTPSPS----- 245 E + YT D+WS G M E+ G +PG ++ + ++ + + P+ Sbjct: 207 IESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDG 266 Query: 246 FMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQN 285 + ++RP +T D P + Sbjct: 267 LYALMSRCWELNPQDRPSFTELREDLENTLKALPPAQEPD 306 >4CRS-A nrPDB Length = 341 Score = 195 bits (496), Expect = 2e-50, Method: Composition-based stats. Identities = 72/326 (22%), Positives = 128/326 (39%), Gaps = 61/326 (18%) Query: 32 SGAQGIVCAAYDTITQQNVAIKKLSR----PFQNVTHAKRAYREFKLMKLVNHKNIIGLL 87 G G V A T + AIK L + V R F+ + V H ++ L Sbjct: 22 RGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVNLF 81 Query: 88 NAFTPQRNLEEFQDVYLVMELM-DANLCQVIQMD-LDHDRMSYLLYQMLCGIKHLHSAGI 145 F + + V VME +L I D R + ++ G+++LH I Sbjct: 82 ACFQTKEH------VCFVMEYAAGGDLMMHIHTDVFSEPRAVFYAACVVLGLQYLHEHKI 135 Query: 146 IHRDLKPSNIVVKADCTLKILDFGLART-AGTTFMMTPYVVTRYYRAPEVILGMGYTENV 204 ++RDLK N+++ + +KI DFGL + G + + T + APEV+ YT V Sbjct: 136 VYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAV 195 Query: 205 DIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENRPRY 264 D W +G ++ EM+ G FPG D + ++ I+ Sbjct: 196 DWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVN--------------------------- 228 Query: 265 TGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRI-----SVDEALKHEY 319 D + R +++A +++ ++L +PE+R+ ++ KH + Sbjct: 229 ----------------DEVRYPRFLSTEAISIMRRLLRRNPERRLGASEKDAEDVKKHPF 272 Query: 320 INVWYDAEEVDAPAPEPYDHSVDERE 345 + + +D P+ ++ RE Sbjct: 273 FRLIDWSALMDKKVKPPFIPTIRGRE 298 >4OTD-A nrPDB Length = 341 Score = 195 bits (496), Expect = 2e-50, Method: Composition-based stats. Identities = 68/327 (20%), Positives = 121/327 (37%), Gaps = 63/327 (19%) Query: 22 SRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSR-PFQNVTHAKRAYREFKLMKLV-- 78 + L +G G G V + + + AIK L + + E +++ V Sbjct: 12 EDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTS 71 Query: 79 -NHKNIIGLLNAFTPQRNLEEFQDVYLVMEL-MDANLCQVIQMD-LDHDRMSYLLYQMLC 135 H ++ L F + V VME +L I D R + ++ Sbjct: 72 AGHPFLVNLFGCFQTPEH------VCFVMEYSAGGDLMLHIHSDVFSEPRAIFYSACVVL 125 Query: 136 GIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLART-AGTTFMMTPYVVTRYYRAPEV 194 G++ LH I++RDLK N+++ + +KI DFGL + G + + T + APEV Sbjct: 126 GLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEV 185 Query: 195 ILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTV 254 + YT VD W +G ++ EM+ G FPG D + ++ I+ Sbjct: 186 LTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVN----------------- 228 Query: 255 RNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRI----- 309 D + R +++A ++ ++L +PE+R+ Sbjct: 229 --------------------------DEVRYPRFLSAEAIGIMRRLLRRNPERRLGSSER 262 Query: 310 SVDEALKHEYINV--WYDAEEVDAPAP 334 ++ K + W P P Sbjct: 263 DAEDVKKQPFFRTLGWEALLARRLPPP 289 >3QGY-A nrPDB Length = 286 Score = 195 bits (495), Expect = 3e-50, Method: Composition-based stats. Identities = 56/259 (21%), Positives = 102/259 (39%), Gaps = 24/259 (9%) Query: 21 HSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNH 80 S ++ IGSG G+V Y + + VAIK + + E ++M ++H Sbjct: 26 PSELTFVQEIGSGQFGLVHLGYW-LNKDKVAIKTIK---EGSMSEDDFIEEAEVMMKLSH 81 Query: 81 KNIIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQMD---LDHDRMSYLLYQMLCG 136 ++ L E + LV E M+ L ++ + + + + G Sbjct: 82 PKLVQLYGVCL------EQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEG 135 Query: 137 IKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRY---YRAPE 193 + +L A +IHRDL N +V + +K+ DFG+ R T T++ + +PE Sbjct: 136 MAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDD-QYTSSTGTKFPVKWASPE 194 Query: 194 VILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQWNKIIEQLGTPSPSF-----M 247 V Y+ D+WS G +M E+ G + + + + I P Sbjct: 195 VFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVY 254 Query: 248 QRLQPTVRNYVENRPRYTG 266 Q + + E+RP ++ Sbjct: 255 QIMNHCWKERPEDRPAFSR 273 >1FVR-A nrPDB Length = 327 Score = 195 bits (495), Expect = 3e-50, Method: Composition-based stats. Identities = 62/267 (23%), Positives = 102/267 (38%), Gaps = 35/267 (13%) Query: 29 PIGSGAQGIVCAAYDTITQQNV--AIKKLSRPFQNVTHAKRAYREFKLM-KLVNHKNIIG 85 IG G G V A + AIK++ + + + + E +++ KL +H NII Sbjct: 32 VIGEGNFGQVLKARIKKDGLRMDAAIKRM-KEYASKDDHRDFAGELEVLCKLGHHPNIIN 90 Query: 86 LLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQMD------------------LDHDRM 126 LL A E +YL +E NL ++ L ++ Sbjct: 91 LLGAC------EHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQL 144 Query: 127 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVT 186 + + G+ +L IHRDL NI+V + KI DFGL+R T + Sbjct: 145 LHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLP 204 Query: 187 RYYRAPEVILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQWNKIIEQLGTPSP- 244 + A E + YT N D+WS G ++ E++ GG + G + + K+ + P Sbjct: 205 VRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPL 264 Query: 245 ----SFMQRLQPTVRNYVENRPRYTGY 267 ++ R RP + Sbjct: 265 NCDDEVYDLMRQCWREKPYERPSFAQI 291 >4M7I-A nrPDB Length = 299 Score = 194 bits (494), Expect = 5e-50, Method: Composition-based stats. Identities = 72/295 (24%), Positives = 119/295 (40%), Gaps = 35/295 (11%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNI 83 + ++ +G G G+V A + + N AIK++ P + + ++ RE K + + H I Sbjct: 7 FEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELA-REKVMREVKALAKLEHPGI 65 Query: 84 IGLLNAFTPQRNLEEFQD------VYLVMELM-DANLCQVIQMDLDHDR-----MSYLLY 131 + NA+ + E+ Q +Y+ M+L NL + + ++ Sbjct: 66 VRYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFL 125 Query: 132 QMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTF------------- 178 Q+ ++ LHS G++HRDLKPSNI D +K+ DFGL Sbjct: 126 QIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYA 185 Query: 179 MMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQ 238 T V T+ Y +PE I G Y+ VDI+S+G I+ E++ F + + Sbjct: 186 RHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELL---YPFSTQMERVRTLTDVRN 242 Query: 239 LGTPS------PSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSR 287 L P P +Q + RP + +F D FP R Sbjct: 243 LKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQR 297 >4Y93-A nrPDB Length = 446 Score = 194 bits (493), Expect = 5e-50, Method: Composition-based stats. Identities = 55/276 (19%), Positives = 109/276 (39%), Gaps = 28/276 (10%) Query: 2 TTAQHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQN 61 +TA + + E+ + T L+ +G+G G+V Q +VAIK + + Sbjct: 174 STAGLGYGSWEIDPKDLTF------LKELGTGQFGVVKYGKWRG-QYDVAIKMIK---EG 223 Query: 62 VTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELM-DANLCQVIQM- 119 E K+M ++H+ ++ L T QR ++++ E M + L ++ Sbjct: 224 SMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQR------PIFIITEYMANGCLLNYLREM 277 Query: 120 --DLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTA--G 175 ++ + + +++L S +HRDL N +V +K+ DFG+ R Sbjct: 278 RHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGMTRYVLDD 337 Query: 176 TTFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQWNK 234 T + +PEV++ ++ DIW+ G +M E+ G + + + + Sbjct: 338 EYTSSTGSKFPVKWASPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEH 397 Query: 235 IIEQLGTPSPSFMQR-----LQPTVRNYVENRPRYT 265 I + L P P + + RP + Sbjct: 398 IAQGLRLPRPHLASERVYAIMYSCWHEKADERPTFK 433 >2OGV-A nrPDB Length = 317 Score = 194 bits (493), Expect = 6e-50, Method: Composition-based stats. Identities = 60/263 (22%), Positives = 104/263 (39%), Gaps = 24/263 (9%) Query: 28 RPIGSGAQGIVCAAYDTITQQN-----VAIKKLSRPFQNVTHAKRAYREFKLMKLV-NHK 81 + +G+GA G V A + VA+K L + + + E K+M + H+ Sbjct: 44 KTLGAGAFGKVVEATAFGLGKEDAVLKVAVKML-KSTAHADEKEALMSELKIMSHLGQHE 102 Query: 82 NIIGLLNAFTPQRNLEEFQDVYLVMELM-------DANLCQVIQMDLDHDRMSYLLYQML 134 NI+ LL A T + + +L+ +A+L + L+ + + Q+ Sbjct: 103 NIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEADLDKEDGRPLELRDLLHFSSQVA 162 Query: 135 CGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMM---TPYVVTRYYRA 191 G+ L S IHRD+ N+++ KI DFGLAR + + A Sbjct: 163 QGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMA 222 Query: 192 PEVILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQWNKIIE------QLGTPSP 244 PE I YT D+WS G ++ E+ G +PG ++ K+++ Q Sbjct: 223 PESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPK 282 Query: 245 SFMQRLQPTVRNYVENRPRYTGY 267 + +Q +RP + Sbjct: 283 NIYSIMQACWALEPTHRPTFQQI 305 >5HIE-A nrPDB Length = 302 Score = 193 bits (491), Expect = 9e-50, Method: Composition-based stats. Identities = 61/276 (22%), Positives = 114/276 (41%), Gaps = 41/276 (14%) Query: 12 EVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYRE 71 E+ D T+ R IGSG+ G V VA+K L + E Sbjct: 32 EIPDGQITVGQR------IGSGSFGTVYKGKWHGD---VAVKML-----TPQQLQAFKNE 77 Query: 72 FKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLC----QVIQMDLDHDRMS 127 +++ H NI+ + T + + +V + + + +I+ + ++ Sbjct: 78 VGVLRKTRHVNILLFMGYSTKPQ-------LAIVTQWCEGSSLYHHLHIIETKFEMIKLI 130 Query: 128 YLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGT---TFMMTPYV 184 + Q G+ +LH+ IIHRDLK +NI + D T+KI DFGLA + Sbjct: 131 DIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLS 190 Query: 185 VTRYYRAPEVIL---GMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKII----- 236 + + APEVI Y+ D+++ G ++ E++ G + + ++ DQ ++ Sbjct: 191 GSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYL 250 Query: 237 ----EQLGTPSPSFMQRLQ-PTVRNYVENRPRYTGY 267 ++ + P M+RL ++ + RP + Sbjct: 251 SPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQI 286 >3BBT-B nrPDB Length = 328 Score = 193 bits (491), Expect = 9e-50, Method: Composition-based stats. Identities = 58/298 (19%), Positives = 108/298 (36%), Gaps = 29/298 (9%) Query: 25 INLRPIGSGAQGIVCAAYDTITQQNV----AIKKLSRPFQNVTHAKRAYREFKLMKLVNH 80 ++ +GSGA G V + V AIK L+ + + E +M ++H Sbjct: 18 KRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVE-FMDEALIMASMDH 76 Query: 81 KNIIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQMDLD---HDRMSYLLYQMLCG 136 +++ LL + LV +LM L + + D + Q+ G Sbjct: 77 PHLVRLLGVCLSP-------TIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKG 129 Query: 137 IKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVV---TRYYRAPE 193 + +L ++HRDL N++VK+ +KI DFGLAR + A E Sbjct: 130 MMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALE 189 Query: 194 VILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQWNKIIEQLGTPSPSF-----M 247 I +T D+WS G + E++ GG + G + + + + P P Sbjct: 190 CIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVY 249 Query: 248 QRLQPTVRNYVENRPRYTGYSFD----RLFPDGLFPNDNNQNSRRKASDARNLLSKML 301 + ++RP++ + + P + + + + +L Sbjct: 250 MVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLL 307 >3V5Q-A nrPDB Length = 297 Score = 193 bits (490), Expect = 1e-49, Method: Composition-based stats. Identities = 57/267 (21%), Positives = 103/267 (38%), Gaps = 41/267 (15%) Query: 28 RPIGSGAQGIVCAAYD-----TITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKN 82 R +G GA G V A T + VA+K L P K RE +L+ + H++ Sbjct: 21 RELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAA--RKDFQREAELLTNLQHEH 78 Query: 83 IIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQ------------------MDLDH 123 I+ + + +V E M +L + ++ +L Sbjct: 79 IVKFYGVC------GDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGL 132 Query: 124 DRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMT-- 181 +M ++ Q+ G+ +L S +HRDL N +V A+ +KI DFG++R +T Sbjct: 133 SQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVG 192 Query: 182 -PYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQWNKI---- 235 ++ + PE I+ +T D+WS G I+ E+ G + + + I Sbjct: 193 GHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGR 252 Query: 236 -IEQLGTPSPSFMQRLQPTVRNYVENR 261 +E+ + + + R Sbjct: 253 VLERPRVCPKEVYDVMLGCWQREPQQR 279 >1U59-A nrPDB Length = 287 Score = 193 bits (490), Expect = 1e-49, Method: Composition-based stats. Identities = 53/252 (21%), Positives = 97/252 (38%), Gaps = 24/252 (9%) Query: 29 PIGSGAQGIVCAAYDTITQQ--NVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGL 86 +G G G V + ++ +VAIK L + + + RE ++M +++ I+ L Sbjct: 17 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKA-DTEEMMREAQIMHQLDNPYIVRL 75 Query: 87 LNAFTPQRNLEEFQDVYLVMELMDANLCQVI----QMDLDHDRMSYLLYQMLCGIKHLHS 142 + + + LVME+ + ++ ++ LL+Q+ G+K+L Sbjct: 76 IGVCQAEA-------LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEE 128 Query: 143 AGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVV----TRYYRAPEVILGM 198 +HRDL N+++ KI DFGL++ G + APE I Sbjct: 129 KNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFR 188 Query: 199 GYTENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQWNKI-----IEQLGTPSPSFMQRLQP 252 ++ D+WS G M E + G + + I +E P + Sbjct: 189 KFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSD 248 Query: 253 TVRNYVENRPRY 264 E+RP + Sbjct: 249 CWIYKWEDRPDF 260 >5HI2-A nrPDB Length = 283 Score = 193 bits (490), Expect = 1e-49, Method: Composition-based stats. Identities = 60/283 (21%), Positives = 116/283 (40%), Gaps = 36/283 (12%) Query: 6 HQHYTVEVGDTNFTIHS-RYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTH 64 H H+ ++ I + + IGSG+ G V VA+K L Sbjct: 3 HHHHGSRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD---VAVKML-----TPQQ 54 Query: 65 AKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN-LCQVIQ---MD 120 + E +++ H NI+ + T + + +V + + + L + Sbjct: 55 LQAFKNEVGVLRKTRHVNILLFMGYSTKPQ-------LAIVTQWCEGSSLYHHLHASETK 107 Query: 121 LDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGT---T 177 + ++ + Q G+ +LH+ IIHRDLK +NI + D T+KI DFGLA + Sbjct: 108 FEMKKLIDIARQTARGMDYLHAKSIIHRDLKSNNIFLHEDNTVKIGDFGLATVKSRWSGS 167 Query: 178 FMMTPYVVTRYYRAPEVIL---GMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNK 234 + + APEVI Y+ D+++ G ++ E++ G + + ++ DQ + Sbjct: 168 HQFEQLSGSILWMAPEVIRMQDSNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIE 227 Query: 235 II---------EQLGTPSPSFMQRLQ-PTVRNYVENRPRYTGY 267 ++ ++ + P M+RL ++ + RP + Sbjct: 228 MVGRGSLSPDLSKVRSNCPKRMKRLMAECLKKKRDERPSFPRI 270 >4XI2-A nrPDB Length = 446 Score = 193 bits (490), Expect = 1e-49, Method: Composition-based stats. Identities = 56/277 (20%), Positives = 111/277 (40%), Gaps = 30/277 (10%) Query: 2 TTAQHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQN 61 +TA + + E+ + T L+ +G+G G+V Q +VAIK + + Sbjct: 173 STAGLGYGSWEIDPKDLTF------LKELGTGQFGVVKYGKWRG-QYDVAIKMIR---EG 222 Query: 62 VTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELM-DANLCQVIQM- 119 E K+M ++H+ ++ L T QR ++++ E M + L ++ Sbjct: 223 SMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQR------PIFIITEYMANGCLLNYLREM 276 Query: 120 --DLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTT 177 ++ + + +++L S +HRDL N +V +K+ DFGL+R Sbjct: 277 RHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDD 336 Query: 178 FMMTPYVVTR---YYRAPEVILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQWN 233 T V ++ + PEV++ ++ DIW+ G +M E+ G + + + + Sbjct: 337 E-YTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAE 395 Query: 234 KIIEQLGTPSPSFMQR-----LQPTVRNYVENRPRYT 265 I + L P + + RP + Sbjct: 396 HIAQGLRLYRPHLASERVYTIMYSCWHEKADERPSFK 432 >1AD5-A nrPDB Length = 438 Score = 192 bits (489), Expect = 1e-49, Method: Composition-based stats. Identities = 59/250 (23%), Positives = 101/250 (40%), Gaps = 32/250 (12%) Query: 28 RPIGSGAQGIVCAA-YDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGL 86 + +G+G G V A Y+ T+ VA+K + + E +MK + H ++ L Sbjct: 188 KKLGAGQFGEVWMATYNKHTK--VAVKTMKP---GSMSVEAFLAEANVMKTLQHDKLVKL 242 Query: 87 LNAFTPQRNLEEFQDVYLVMELM-DANLCQVIQMDL----DHDRMSYLLYQMLCGIKHLH 141 T + +Y++ E M +L ++ D ++ Q+ G+ + Sbjct: 243 HAVVTKE-------PIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIE 295 Query: 142 SAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGYT 201 IHRDL+ +NI+V A KI DFGLAR + APE I +T Sbjct: 296 QRNYIHRDLRAANILVSASLVCKIADFGLARV--------GAKFPIKWTAPEAINFGSFT 347 Query: 202 ENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQWNKIIEQLGTPSP-----SFMQRLQPTVR 255 D+WS G ++ E++ G + +PG + + + P P + + Sbjct: 348 IKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWK 407 Query: 256 NYVENRPRYT 265 N E RP + Sbjct: 408 NRPEERPTFE 417 >4H1J-A nrPDB Length = 293 Score = 192 bits (489), Expect = 2e-49, Method: Composition-based stats. Identities = 54/254 (21%), Positives = 102/254 (40%), Gaps = 23/254 (9%) Query: 28 RPIGSGAQGIVCAAY---DTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNII 84 R +G G G V + NVA+K + + + ++ E +MK ++H +I+ Sbjct: 30 RILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDC-TLDNKEKFMSEAVIMKNLDHPHIV 88 Query: 85 GLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQMDLDHDRMSY---LLYQMLCGIKHL 140 L+ + +++MEL L ++ + + ++ Q+ + +L Sbjct: 89 KLIGIIEEE-------PTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYL 141 Query: 141 HSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVV--TRYYRAPEVILGM 198 S +HRD+ NI+V + +K+ DFGL+R V + +PE I Sbjct: 142 ESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPESINFR 201 Query: 199 GYTENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQWNKIIEQLGTP----SPSFMQRLQPT 253 +T D+W M E++ G F ++ D + + P P + L Sbjct: 202 RFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTR 261 Query: 254 VRNY-VENRPRYTG 266 +Y +RPR+T Sbjct: 262 CWDYDPSDRPRFTE 275 >1BYG-A nrPDB Length = 278 Score = 192 bits (488), Expect = 2e-49, Method: Composition-based stats. Identities = 56/254 (22%), Positives = 99/254 (38%), Gaps = 24/254 (9%) Query: 22 SRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHK 81 L+ IG G G V VA+K + N A+ E +M + H Sbjct: 21 KELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIK----NDATAQAFLAEASVMTQLRHS 74 Query: 82 NIIGLLNAFTPQRNLEEFQDVYLVMELM-DANLCQVIQMD----LDHDRMSYLLYQMLCG 136 N++ LL +EE +Y+V E M +L ++ L D + + Sbjct: 75 NLVQLLGVI-----VEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEA 129 Query: 137 IKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVIL 196 +++L +HRDL N++V D K+ DFGL + A +T + + APE + Sbjct: 130 MEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ--DTGKLPVKWTAPEALR 187 Query: 197 GMGYTENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQWNKIIEQLGT-----PSPSFMQRL 250 ++ D+WS G ++ E+ G V +P D ++ + P+ + + Sbjct: 188 EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVM 247 Query: 251 QPTVRNYVENRPRY 264 + RP + Sbjct: 248 KNCWHLDAAMRPSF 261 >6GVJ-A nrPDB Length = 429 Score = 192 bits (488), Expect = 2e-49, Method: Composition-based stats. Identities = 76/321 (23%), Positives = 120/321 (37%), Gaps = 66/321 (20%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVN-HKN 82 Y L+ IGSG V + +Q AIK ++ + E + + H + Sbjct: 146 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 204 Query: 83 -IIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMD--LDHDRMSYLLYQMLCGIKH 139 II L + Q +Y+VME + +L ++ +D ML + Sbjct: 205 KIIRLYDYEITD------QYIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHT 258 Query: 140 LHSAGIIHRDLKPSNIVVKADCTLKILDFGLA---RTAGTTFMMTPYVVTRYYRAPEVIL 196 +H GI+H DLKP+N ++ D LK++DFG+A + T+ + V T Y PE I Sbjct: 259 IHQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIK 317 Query: 197 GMGYTEN-----------VDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPS 245 M + D+WS+GCI+ M G F +II Q+ Sbjct: 318 DMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ---------QIINQI------ 362 Query: 246 FMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDP 305 + PN + D +++L L DP Sbjct: 363 -------------------------SKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDP 397 Query: 306 EQRISVDEALKHEYINVWYDA 326 +QRIS+ E L H Y+ + Sbjct: 398 KQRISIPELLAHPYVQIQTHP 418 >4XUF-A nrPDB Length = 297 Score = 192 bits (488), Expect = 2e-49, Method: Composition-based stats. Identities = 66/297 (22%), Positives = 109/297 (36%), Gaps = 50/297 (16%) Query: 15 DTNFTIH-SRYINLRPIGSGAQGIVCAAYD---TITQQ--NVAIKKLSRPFQNVTHAKRA 68 D + + +GSGA G V A + T VA+K L + + + + Sbjct: 1 DLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKML-KEKADSSEREAL 59 Query: 69 YREFKLMKLV-NHKNIIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQMD---LDH 123 E K+M + +H+NI+ LL A T +YL+ E +L ++ Sbjct: 60 MSELKMMTQLGSHENIVNLLGACTLSG------PIYLIFEYCCYGDLLNYLRSKREKFSE 113 Query: 124 DRMSY----------------------LLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADC 161 D + Y YQ+ G++ L +HRDL N++V Sbjct: 114 DEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGK 173 Query: 162 TLKILDFGLARTAGTTFMM---TPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIR 218 +KI DFGLAR + + + APE + YT D+WS G ++ E+ Sbjct: 174 VVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFS 233 Query: 219 -GGVLFPGTDHIDQWNKIIE------QLGTPSPSFMQRLQPTVRNYVENRPRYTGYS 268 G +PG + K+I+ Q + +Q RP + + Sbjct: 234 LGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLT 290 >3CJF-A nrPDB Length = 309 Score = 192 bits (488), Expect = 2e-49, Method: Composition-based stats. Identities = 64/277 (23%), Positives = 110/277 (39%), Gaps = 37/277 (13%) Query: 21 HSRYINLRPIGSGAQGIVCAA----YDT-ITQQNVAIKKLSRPFQNVTHAKRAYREFKLM 75 R +P+G GA G V A D T + VA+K L + H E K++ Sbjct: 26 RDRLNLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHR-ALMSELKIL 84 Query: 76 -KLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQMDLDH---------- 123 + +H N++ LL A T + +++E NL ++ + Sbjct: 85 IHIGHHLNVVNLLGACTKPG-----GPLMVIVEFCKFGNLSTYLRSKRNEFVPYKDLYKD 139 Query: 124 ----DRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTA---GT 176 + + +Q+ G++ L S IHRDL NI++ +KI DFGLAR Sbjct: 140 FLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPD 199 Query: 177 TFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQWNKI 235 + + APE I YT D+WS G ++ E+ G +PG +++ + Sbjct: 200 YVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRR 259 Query: 236 IE---QLGTP---SPSFMQRLQPTVRNYVENRPRYTG 266 ++ ++ P +P Q + RP ++ Sbjct: 260 LKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSE 296 >5AMN-A nrPDB Length = 299 Score = 192 bits (487), Expect = 3e-49, Method: Composition-based stats. Identities = 60/284 (21%), Positives = 111/284 (39%), Gaps = 35/284 (12%) Query: 15 DTNFTIHSRYINL-RPIGSGAQGIVCAA-----YDTITQQNVAIKKLSRPFQNVTHAKRA 68 D + + + L + +G G G V A VA+K L + + + + Sbjct: 15 DPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKML-KENASPSELRDL 73 Query: 69 YREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVI----------- 117 EF ++K VNH ++I L A + + L++E + Sbjct: 74 LSEFNVLKQVNHPHVIKLYGACSQDG------PLLLIVEYAKYGSLRGFLRESRKVGPGY 127 Query: 118 --QMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTA- 174 + L + +Q+ G+++L ++HRDL NI+V +KI DFGL+R Sbjct: 128 PDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVY 187 Query: 175 --GTTFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQ 231 + + + + A E + YT D+WS G ++ E++ GG +PG Sbjct: 188 EEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERL 247 Query: 232 WNKI-----IEQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFD 270 +N + +E+ S + + + + RP + S D Sbjct: 248 FNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKD 291 >2OZO-A nrPDB Length = 613 Score = 192 bits (487), Expect = 3e-49, Method: Composition-based stats. Identities = 52/252 (20%), Positives = 97/252 (38%), Gaps = 24/252 (9%) Query: 29 PIGSGAQGIVCAAYDTITQQ--NVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGL 86 +G G G V + ++ +VAIK L + + + RE ++M +++ I+ L Sbjct: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKA-DTEEMMREAQIMHQLDNPYIVRL 401 Query: 87 LNAFTPQRNLEEFQDVYLVMELMDANLCQVI----QMDLDHDRMSYLLYQMLCGIKHLHS 142 + + + LVME+ + ++ ++ LL+Q+ G+K+L Sbjct: 402 IGVCQAEA-------LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEE 454 Query: 143 AGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVV----TRYYRAPEVILGM 198 +HR+L N+++ KI DFGL++ G + APE I Sbjct: 455 KNFVHRNLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFR 514 Query: 199 GYTENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQWNKI-----IEQLGTPSPSFMQRLQP 252 ++ D+WS G M E + G + + I +E P + Sbjct: 515 KFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSD 574 Query: 253 TVRNYVENRPRY 264 E+RP + Sbjct: 575 CWIYKWEDRPDF 586 >3OMV-A nrPDB Length = 307 Score = 192 bits (487), Expect = 3e-49, Method: Composition-based stats. Identities = 61/259 (23%), Positives = 108/259 (41%), Gaps = 32/259 (12%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNA 89 IGSG+ G V VA+K L + E +++ H NI+ + Sbjct: 44 IGSGSFGTVYKGKWHGD---VAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGY 100 Query: 90 FTPQRNLEEFQDVYLVMELMDANLC----QVIQMDLDHDRMSYLLYQMLCGIKHLHSAGI 145 T + +V + + + V + ++ + Q G+ +LH+ I Sbjct: 101 MTKDN-------LAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNI 153 Query: 146 IHRDLKPSNIVVKADCTLKILDFGLA----RTAGTTFMMTPYVVTRYYRAPEVIL---GM 198 IHRD+K +NI + T+KI DFGLA R +G+ + P + + APEVI Sbjct: 154 IHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQP-TGSVLWMAPEVIRMQDNN 212 Query: 199 GYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKII---------EQLGTPSPSFMQR 249 ++ D++S G ++ E++ G + + ++ DQ ++ +L P M+R Sbjct: 213 PFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKR 272 Query: 250 L-QPTVRNYVENRPRYTGY 267 L V+ E RP + Sbjct: 273 LVADCVKKVKEERPLFPQI 291 >3M42-A nrPDB Length = 299 Score = 191 bits (486), Expect = 3e-49, Method: Composition-based stats. Identities = 66/352 (18%), Positives = 128/352 (36%), Gaps = 81/352 (23%) Query: 15 DTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKL 74 N I + + +G G G V ++ TQ+ A+K L +A RE +L Sbjct: 11 KKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-------QDCPKARREVEL 63 Query: 75 M-KLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN-----LCQVIQMDLDHDRMSY 128 + +I+ +++ + + + + +VME +D + S Sbjct: 64 HWRASQCPHIVRIVDVY--ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASE 121 Query: 129 LLYQMLCGIKHLHSAGIIHRDLKPSNIVVKA---DCTLKILDFGLARTAGTTFMMTPYVV 185 ++ + I++LHS I HRD+KP N++ + + LK+ DFG A+ Sbjct: 122 IMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT---------- 171 Query: 186 TRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPS 245 G Y ++ D+WS+G IM ++ G F + Sbjct: 172 -----------GEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGL---------------- 204 Query: 246 FMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDP 305 + ++ R R Y F N + + + L+ +L +P Sbjct: 205 -------AISPGMKTRIRMGQYEFP------------NPEWSEVSEEVKMLIRNLLKTEP 245 Query: 306 EQRISVDEALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYE 357 QR+++ E + H +I P+ H+ + E+W+++ E Sbjct: 246 TQRMTITEFMNHPWIMQ-------STKVPQTPLHTSRVLKEDKERWEDVKEE 290 >5AP3-A nrPDB Length = 313 Score = 191 bits (486), Expect = 3e-49, Method: Composition-based stats. Identities = 80/340 (23%), Positives = 126/340 (37%), Gaps = 72/340 (21%) Query: 11 VEVGDTNFTIHSR------YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTH 64 V++G N S Y L+ IGSG V + +Q AIK ++ + Sbjct: 11 VDLGTENLYFQSMSVKGRIYSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQT 69 Query: 65 AKRAYREFKLMKLVN-HKN-IIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMD-- 120 E + + H + II L + Q +Y+VME + +L ++ Sbjct: 70 LDSYRNEIAYLNKLQQHSDKIIRLYDYEITD------QYIYMVMECGNIDLNGWLKKKKS 123 Query: 121 LDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLA---RTAGTT 177 +D ML + +H GI+H DLKP+N ++ D LK++DFG+A + T+ Sbjct: 124 IDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTS 182 Query: 178 FMMTPYVVTRYYRAPEVILGMGYTEN-----------VDIWSVGCIMGEMIRGGVLFPGT 226 + V T Y PE I M + D+WS+GCI+ M G F Sbjct: 183 VVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ-- 240 Query: 227 DHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNS 286 +II Q+ + PN + Sbjct: 241 -------QIINQI-------------------------------SKLHAIIDPNHEIEFP 262 Query: 287 RRKASDARNLLSKMLVIDPEQRISVDEALKHEYINVWYDA 326 D +++L L DP+QRIS+ E L H Y+ + Sbjct: 263 DIPEKDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQTHP 302 >3QUP-A nrPDB Length = 323 Score = 191 bits (486), Expect = 3e-49, Method: Composition-based stats. Identities = 55/271 (20%), Positives = 103/271 (38%), Gaps = 21/271 (7%) Query: 21 HSRYINLRPIGSGAQGIVCAAYDTITQ---QNVAIKKLSRPFQNVTHAKRAYREFKLMKL 77 ++ R +G G G V A VA+K L + + RE MK Sbjct: 22 EQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKE 81 Query: 78 VNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVI--------QMDLDHDRMSY 128 +H ++ L+ R +++ M +L + +L + Sbjct: 82 FDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLVR 141 Query: 129 LLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTR- 187 + + CG+++L S IHRDL N ++ D T+ + DFGL+R + ++ Sbjct: 142 FMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKL 201 Query: 188 --YYRAPEVILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQWNKII--EQLGTP 242 + A E + YT + D+W+ G M E++ G + G ++ + +N +I +L P Sbjct: 202 PVKWLALESLADNLYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQP 261 Query: 243 S---PSFMQRLQPTVRNYVENRPRYTGYSFD 270 + + RP +T + Sbjct: 262 PECMEEVYDLMYQCWSADPKQRPSFTCLRME 292 >3BEA-A nrPDB Length = 333 Score = 191 bits (486), Expect = 4e-49, Method: Composition-based stats. Identities = 60/273 (21%), Positives = 101/273 (36%), Gaps = 40/273 (14%) Query: 28 RPIGSGAQGIVCAAYDTITQQN-----VAIKKLSRPFQNVTHAKRAYREFKLMKLV-NHK 81 + +G+GA G V A + VA+K L + + + E K+M + H+ Sbjct: 52 KTLGAGAFGKVVEATAFGLGKEDAVLKVAVKML-KSTAHADEKEALMSELKIMSHLGQHE 110 Query: 82 NIIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQMD----------------LDHD 124 NI+ LL A T V ++ E +L ++ L Sbjct: 111 NIVNLLGACT------HGGPVLVITEYCCYGDLLNFLRRKSRVLETDPAFAIANSTLSTR 164 Query: 125 RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMM---T 181 + + Q+ G+ L S IHRD+ N+++ KI DFGLAR Sbjct: 165 DLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKG 224 Query: 182 PYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQWNKIIE--- 237 + + APE I YT D+WS G ++ E+ G +PG ++ K+++ Sbjct: 225 NARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGY 284 Query: 238 ---QLGTPSPSFMQRLQPTVRNYVENRPRYTGY 267 Q + +Q +RP + Sbjct: 285 QMAQPAFAPKNIYSIMQACWALEPTHRPTFQQI 317 >1LUF-A nrPDB Length = 343 Score = 191 bits (485), Expect = 4e-49, Method: Composition-based stats. Identities = 58/286 (20%), Positives = 99/286 (34%), Gaps = 52/286 (18%) Query: 25 INLRPIGSGAQGIVCAA-------YDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKL 77 +R IG GA G V A Y+ T VA+K L + + RE LM Sbjct: 50 EYVRDIGEGAFGRVFQARAPGLLPYEPFT--MVAVKML-KEEASADMQADFQREAALMAE 106 Query: 78 VNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQM----------------- 119 ++ NI+ LL + + L+ E M +L + ++ Sbjct: 107 FDNPNIVKLLGVC------AVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTR 160 Query: 120 ---------DLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGL 170 L + Q+ G+ +L +HRDL N +V + +KI DFGL Sbjct: 161 ARVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGL 220 Query: 171 ARTAGTTFMMT---PYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGV-LFPGT 226 +R + + + PE I YT D+W+ G ++ E+ G+ + G Sbjct: 221 SRNIYSADYYKADGNDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGM 280 Query: 227 DHIDQWNKIIEQLGTPSP-----SFMQRLQPTVRNYVENRPRYTGY 267 H + + + P ++ +RP + Sbjct: 281 AHEEVIYYVRDGNILACPENCPLELYNLMRLCWSKLPADRPSFCSI 326 >3SXS-A nrPDB Length = 268 Score = 191 bits (485), Expect = 5e-49, Method: Composition-based stats. Identities = 54/255 (21%), Positives = 104/255 (40%), Gaps = 24/255 (9%) Query: 25 INLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNII 84 L+ +GSG G+V Q +VA+K + + ++E + M ++H ++ Sbjct: 11 TLLKELGSGQFGVVKLGKWKG-QYDVAVKMIK---EGSMSEDEFFQEAQTMMKLSHPKLV 66 Query: 85 GLLNAFTPQRNLEEFQDVYLVMELM-DANLCQVIQ---MDLDHDRMSYLLYQMLCGIKHL 140 + + +Y+V E + + L ++ L+ ++ + Y + G+ L Sbjct: 67 KFYGVCSKEY------PIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFL 120 Query: 141 HSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRY---YRAPEVILG 197 S IHRDL N +V D +K+ DFG+ R ++ V T++ + APEV Sbjct: 121 ESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSS-VGTKFPVKWSAPEVFHY 179 Query: 198 MGYTENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQWNKIIEQLGTPSPSF-----MQRLQ 251 Y+ D+W+ G +M E+ G + + + + K+ + P Q + Sbjct: 180 FKYSSKSDVWAFGILMWEVFSLGKMPYDLYTNSEVVLKVSQGHRLYRPHLASDTIYQIMY 239 Query: 252 PTVRNYVENRPRYTG 266 E RP + Sbjct: 240 SCWHELPEKRPTFQQ 254 >1K9A-A nrPDB Length = 450 Score = 191 bits (485), Expect = 5e-49, Method: Composition-based stats. Identities = 56/254 (22%), Positives = 98/254 (38%), Gaps = 24/254 (9%) Query: 22 SRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHK 81 L+ IG G G V VA+K + N A+ E +M + H Sbjct: 193 KELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIK----NDATAQAFLAEASVMTQLRHS 246 Query: 82 NIIGLLNAFTPQRNLEEFQDVYLVMELM-DANLCQVIQMD----LDHDRMSYLLYQMLCG 136 N++ LL +EE +Y+V E M +L ++ L D + + Sbjct: 247 NLVQLLGVI-----VEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEA 301 Query: 137 IKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVIL 196 +++L +HRDL N++V D K+ DFGL + A +T + + APE + Sbjct: 302 MEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ--DTGKLPVKWTAPEALR 359 Query: 197 GMGYTENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQWNKIIEQLGT-----PSPSFMQRL 250 ++ D+WS G ++ E+ G V +P D ++ + P+ + Sbjct: 360 EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVM 419 Query: 251 QPTVRNYVENRPRY 264 + RP + Sbjct: 420 KNCWHLDAATRPTF 433 >6E4F-A nrPDB Length = 290 Score = 190 bits (484), Expect = 6e-49, Method: Composition-based stats. Identities = 56/276 (20%), Positives = 110/276 (39%), Gaps = 30/276 (10%) Query: 3 TAQHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNV 62 TA + + E+ + T L+ +G+G G+V Q +VAIK + + Sbjct: 18 TAGLGYGSWEIDPKDLTF------LKELGTGQFGVVKYGKWRG-QYDVAIKMIK---EGS 67 Query: 63 THAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELM-DANLCQVIQM-- 119 E K+M ++H+ ++ L T QR ++++ E M + L ++ Sbjct: 68 MSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQR------PIFIITEYMANGCLLNYLREMR 121 Query: 120 -DLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTF 178 ++ + + +++L S +HRDL N +V +K+ DFGL+R Sbjct: 122 HRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDE 181 Query: 179 MMTPYVVTR---YYRAPEVILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQWNK 234 T V ++ + PEV++ ++ DIW+ G +M E+ G + + + + Sbjct: 182 -YTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEH 240 Query: 235 IIEQLGTPSPSFMQR-----LQPTVRNYVENRPRYT 265 I + L P + + RP + Sbjct: 241 IAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFK 276 >5X02-A nrPDB Length = 347 Score = 190 bits (484), Expect = 6e-49, Method: Composition-based stats. Identities = 66/297 (22%), Positives = 109/297 (36%), Gaps = 50/297 (16%) Query: 15 DTNFTIH-SRYINLRPIGSGAQGIVCAAYD---TITQQ--NVAIKKLSRPFQNVTHAKRA 68 D + + +GSGA G V A + T VA+K L + + + + Sbjct: 40 DLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKML-KEKADSSEREAL 98 Query: 69 YREFKLMKLV-NHKNIIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQMD---LDH 123 E K+M + +H+NI+ LL A T +YL+ E +L ++ Sbjct: 99 MSELKMMTQLGSHENIVNLLGACTLSG------PIYLIFEYCCYGDLLNYLRSKREKFSE 152 Query: 124 DRMSY----------------------LLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADC 161 D + Y YQ+ G++ L +HRDL N++V Sbjct: 153 DEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGK 212 Query: 162 TLKILDFGLARTAGTTFMM---TPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIR 218 +KI DFGLAR + + + APE + YT D+WS G ++ E+ Sbjct: 213 VVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFS 272 Query: 219 -GGVLFPGTDHIDQWNKIIE------QLGTPSPSFMQRLQPTVRNYVENRPRYTGYS 268 G +PG + K+I+ Q + +Q RP + + Sbjct: 273 LGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLT 329 >3KRL-A nrPDB Length = 335 Score = 190 bits (484), Expect = 6e-49, Method: Composition-based stats. Identities = 59/269 (21%), Positives = 101/269 (37%), Gaps = 30/269 (11%) Query: 28 RPIGSGAQGIVCAAYDTITQQN-----VAIKKLSRPFQNVTHAKRAYREFKLMKLV-NHK 81 + +G+GA G V A + VA+K L + + + E K+M + H+ Sbjct: 52 KTLGAGAFGKVVEATAFGLGKEDAVLKVAVKML-KSTAHADEKEALMSELKIMSHLGQHE 110 Query: 82 NIIGLLNAFTPQRNLEEFQDVYLVMELMD-------------ANLCQVIQMDLDHDRMSY 128 NI+ LL A T + + +L++ N + L + + Sbjct: 111 NIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKRPPGLEYSYNPSHNPEEQLSSRDLLH 170 Query: 129 LLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMM---TPYVV 185 Q+ G+ L S IHRD+ N+++ KI DFGLAR + Sbjct: 171 FSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARL 230 Query: 186 TRYYRAPEVILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQWNKIIE------Q 238 + APE I YT D+WS G ++ E+ G +PG ++ K+++ Q Sbjct: 231 PVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQ 290 Query: 239 LGTPSPSFMQRLQPTVRNYVENRPRYTGY 267 + +Q +RP + Sbjct: 291 PAFAPKNIYSIMQACWALEPTHRPTFQQI 319 >3DLS-A nrPDB Length = 335 Score = 190 bits (484), Expect = 7e-49, Method: Composition-based stats. Identities = 71/332 (21%), Positives = 125/332 (37%), Gaps = 74/332 (22%) Query: 21 HSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRP------FQNVTHAKRAYREFKL 74 +Y + P+GSGA G V A D + V +K + + + + E + Sbjct: 23 SQKYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAI 82 Query: 75 MKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVI----QMDLDHDRMSYLL 130 + V H NII +L+ F Q + LVME + L LD SY+ Sbjct: 83 LSRVEHANIIKVLDIFENQGFFQ------LVMEKHGSGLDLFAFIDRHPRLDEPLASYIF 136 Query: 131 YQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYR 190 Q++ + +L IIHRD+K NIV+ D T+K++DFG A + + T Y Sbjct: 137 RQLVSAVGYLRLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYC 196 Query: 191 APEVILGMGY-TENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQR 249 APEV++G Y +++WS+G + ++ F + + +E P Sbjct: 197 APEVLMGNPYRGPELEMWSLGVTLYTLVFEENPFC------ELEETVEAAIHPP------ 244 Query: 250 LQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRI 309 + + +L+S +L PE+R Sbjct: 245 -------------------------------------YLVSKELMSLVSGLLQPVPERRT 267 Query: 310 SVDEALKHEYINV--------WYDAEEVDAPA 333 ++++ + ++ W + V+ P Sbjct: 268 TLEKLVTDPWVTQPVNLADYTWEEVFRVNKPE 299 >6DBN-A nrPDB Length = 316 Score = 190 bits (483), Expect = 7e-49, Method: Composition-based stats. Identities = 63/314 (20%), Positives = 117/314 (37%), Gaps = 47/314 (14%) Query: 10 TVEVGDTNFTIHSRYIN-LRPIGSGAQGIVCAAYDTI----TQQNVAIKKLSRPFQNVTH 64 EV T+F R++ +R +G G G V T + VA+K L +P H Sbjct: 24 ATEVDPTHFE--KRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSL-KPESGGNH 80 Query: 65 AKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQM---D 120 +E ++++ + H+NI+ T + L+ME + +L + + Sbjct: 81 IADLKKEIEILRNLYHENIVKYKGICTEDG----GNGIKLIMEFLPSGSLKEYLPKNKNK 136 Query: 121 LDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMM 180 ++ + Q+ G+ +L S +HRDL N++V+++ +KI DFGL + T Sbjct: 137 INLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEY 196 Query: 181 TPYV----VTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKII 236 ++ APE ++ + D+WS G + E++ + +D Sbjct: 197 YTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLT----YCDSDS-------- 244 Query: 237 EQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNL 296 +P F++ + PT R + L + L Sbjct: 245 ----SPMALFLKMIGPTHGQMTVTR-----------LVNTLKEGKRLPCPPNCPDEVYQL 289 Query: 297 LSKMLVIDPEQRIS 310 + K P R S Sbjct: 290 MRKCWEFQPSNRTS 303 >4OW8-A nrPDB Length = 283 Score = 190 bits (482), Expect = 9e-49, Method: Composition-based stats. Identities = 68/279 (24%), Positives = 113/279 (40%), Gaps = 7/279 (2%) Query: 16 TNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQ-NVTHAKRAYREFKL 74 T+ RY R I +G G V A D + VA+K L F + +R E + Sbjct: 5 VGVTLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEART 64 Query: 75 MKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMD---LDHDRMSYLLY 131 ++NH I + + + + E + YLVMEL++ + L +L Sbjct: 65 TAMLNHPGIASVHD-YGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLE 123 Query: 132 QMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTP--YVVTRYY 189 Q ++ H+AG++HRD+KP NI++ +KI DFG+A+ + + T Y Sbjct: 124 QTGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQY 183 Query: 190 RAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQR 249 APE LG + D++S+G + E + G F G + K I++ P P + Sbjct: 184 IAPEQALGHDASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKEPPPPLPPDLPP 243 Query: 250 LQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRR 288 + + Y F D + + R Sbjct: 244 NVRELIEITLVKNPAMRYRSGGPFADAVAAVRAGRRPPR 282 >6B2Q-A nrPDB Length = 317 Score = 190 bits (482), Expect = 9e-49, Method: Composition-based stats. Identities = 62/229 (27%), Positives = 102/229 (44%), Gaps = 7/229 (3%) Query: 16 TNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQ-NVTHAKRAYREFKL 74 T+ RY R I +G G V A D + VA+K L F + +R E + Sbjct: 26 VGVTLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEART 85 Query: 75 MKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMD---LDHDRMSYLLY 131 ++NH I + + + + E + YLVMEL++ + L +L Sbjct: 86 TAMLNHPGIASVHD-YGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLE 144 Query: 132 QMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTP--YVVTRYY 189 Q ++ H+AG++HRD+KP NI++ +KI DFG+A+ + + T Y Sbjct: 145 QTGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQY 204 Query: 190 RAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQ 238 APE LG + D++S+G + E + G F G + K I++ Sbjct: 205 IAPEQALGHDASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKE 253 >4X3F-A nrPDB Length = 337 Score = 190 bits (482), Expect = 9e-49, Method: Composition-based stats. Identities = 62/229 (27%), Positives = 102/229 (44%), Gaps = 7/229 (3%) Query: 16 TNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQ-NVTHAKRAYREFKL 74 T+ RY R I +G G V A D + VA+K L F + +R E + Sbjct: 6 VGVTLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEART 65 Query: 75 MKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMD---LDHDRMSYLLY 131 ++NH I + + + + E + YLVMEL++ + L +L Sbjct: 66 TAMLNHPGIASVHD-YGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLE 124 Query: 132 QMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTP--YVVTRYY 189 Q ++ H+AG++HRD+KP NI++ +KI DFG+A+ + + T Y Sbjct: 125 QTGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQY 184 Query: 190 RAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQ 238 APE LG + D++S+G + E + G F G + K I++ Sbjct: 185 IAPEQALGHDASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKE 233 >1ZXE-A nrPDB Length = 303 Score = 190 bits (482), Expect = 1e-48, Method: Composition-based stats. Identities = 75/337 (22%), Positives = 129/337 (38%), Gaps = 71/337 (21%) Query: 22 SRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHK 81 S + + +G GA G V A + + + AIKK+ + ++ E L+ +NH+ Sbjct: 6 SDFEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRHTEEKLS---TILSEVMLLASLNHQ 62 Query: 82 NIIGLLNAFTPQRNLEEFQD-------VYLVMELMDA-NLCQVIQMD-LDHDRMSY--LL 130 ++ A+ +RN + +++ ME + L +I + L+ R Y L Sbjct: 63 YVVRYYAAWLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQRDEYWRLF 122 Query: 131 YQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTA---------------G 175 Q+L + ++HS GIIHR+LKP NI + +KI DFGLA+ G Sbjct: 123 RQILEALSYIHSQGIIHRNLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKLDSQNLPG 182 Query: 176 TTFMMTPYVVTRYYRAPEVILGMG-YTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNK 234 ++ +T + T Y A EV+ G G Y E +D++S+G I EMI F K Sbjct: 183 SSDNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMI---YPFSTGMERVNILK 239 Query: 235 IIEQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDAR 294 + + P + V + Sbjct: 240 KLRSVSIEFPPDFDDNKMKVEKKI------------------------------------ 263 Query: 295 NLLSKMLVIDPEQRISVDEALKHEYINVWYDAEEVDA 331 + ++ DP +R L ++ V + E + Sbjct: 264 --IRLLIDHDPNKRPGARTLLNSGWLPVKHQDEVIKE 298 >3ZBF-A nrPDB Length = 322 Score = 190 bits (482), Expect = 1e-48, Method: Composition-based stats. Identities = 59/292 (20%), Positives = 107/292 (36%), Gaps = 37/292 (12%) Query: 3 TAQHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTI-----TQQ-NVAIKKLS 56 T ++ ++ + + + +GSGA G V + + VA+K L Sbjct: 14 TTENLYFQGSIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLK 73 Query: 57 RPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDA-NLCQ 115 + + + +E LM NH NI+ L + Y+++ELM+ +L Sbjct: 74 KGSTDQEKIE-FLKEAHLMSKFNHPNILKQLGVCL------LNEPQYIILELMEGGDLLT 126 Query: 116 VIQM---------DLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-----ADC 161 ++ L + L + G +L IHRDL N +V + Sbjct: 127 YLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPR 186 Query: 162 TLKILDFGLARTA-GTTFMMTPYVV--TRYYRAPEVILGMGYTENVDIWSVGCIMGEMIR 218 +KI DFGLAR + + APE ++ +T D+WS G ++ E++ Sbjct: 187 IVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILT 246 Query: 219 -GGVLFPGTDHIDQWNKI-----IEQLGTPSPSFMQRLQPTVRNYVENRPRY 264 G +P ++D N + +E + + RP + Sbjct: 247 LGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTF 298 >2A1A-B nrPDB Length = 284 Score = 189 bits (481), Expect = 1e-48, Method: Composition-based stats. Identities = 59/218 (27%), Positives = 99/218 (45%), Gaps = 23/218 (10%) Query: 15 DTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKL 74 D F + + + IGSG G V A I + IK++ + ++A RE K Sbjct: 6 DKRFGMD--FKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKY------NNEKAEREVKA 57 Query: 75 MKLVNHKNIIGLLNAF----------TPQRNLEEFQDVYLVMELMD-ANLCQVIQM---- 119 + ++H NI+ + + + + + +++ ME D L Q I+ Sbjct: 58 LAKLDHVNIVHYNGCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGE 117 Query: 120 DLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFM 179 LD L Q+ G+ ++HS +I+RDLKPSNI + +KI DFGL + Sbjct: 118 KLDKVLALELFEQITKGVDYIHSKKLINRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGK 177 Query: 180 MTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMI 217 T T Y +PE I Y + VD++++G I+ E++ Sbjct: 178 RTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELL 215 >2W1I-A nrPDB Length = 326 Score = 189 bits (481), Expect = 1e-48, Method: Composition-based stats. Identities = 62/307 (20%), Positives = 114/307 (37%), Gaps = 47/307 (15%) Query: 3 TAQHQHYTVEVGDT-----NFTIHSRYIN-LRPIGSGAQGIVCAAYDTI----TQQNVAI 52 T ++ ++ +G R++ L+ +G G G V T + VA+ Sbjct: 16 TTENLYFQGAMGSAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAV 75 Query: 53 KKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMD-A 111 KKL + H + RE +++K + H NI+ L+ME + Sbjct: 76 KKLQHSTEE--HLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLK----LIMEYLPYG 129 Query: 112 NLCQVIQM---DLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDF 168 +L +Q +DH ++ Q+ G+++L + IHRDL NI+V+ + +KI DF Sbjct: 130 SLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDF 189 Query: 169 GLARTAGTTFMMT----PYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRG----- 219 GL + P ++ APE + ++ D+WS G ++ E+ Sbjct: 190 GLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSK 249 Query: 220 GVL-----------------FPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENRP 262 F + + ++ G P +M + N V RP Sbjct: 250 SPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMI-MTECWNNNVNQRP 308 Query: 263 RYTGYSF 269 + + Sbjct: 309 SFRDLAL 315 >3C1X-A nrPDB Length = 373 Score = 189 bits (481), Expect = 1e-48, Method: Composition-based stats. Identities = 62/275 (22%), Positives = 112/275 (40%), Gaps = 30/275 (10%) Query: 11 VEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTIT---QQNVAIKKLSRPFQNVTHAKR 67 V +G ++ +H IG G G V + + A+K L+R ++ + Sbjct: 82 VVIGPSSLIVHFN----EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNR-ITDIGEVSQ 136 Query: 68 AYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQMDLDHDRM 126 E +MK +H N++ LL L +V+ M +L I+ + + + Sbjct: 137 FLTEGIIMKDFSHPNVLSLLGIC-----LRSEGSPLVVLPYMKHGDLRNFIRNETHNPTV 191 Query: 127 SYLL---YQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLAR-----TAGTTF 178 L+ Q+ G+K L S +HRDL N ++ T+K+ DFGLAR + Sbjct: 192 KDLIGFGLQVAKGMKFLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEFDSVH 251 Query: 179 MMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGTDHID------Q 231 T + + A E + +T D+WS G ++ E++ G +P + D Q Sbjct: 252 NKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQ 311 Query: 232 WNKIIEQLGTPSPSFMQRLQPTVRNYVENRPRYTG 266 ++++ P P + L+ E RP ++ Sbjct: 312 GRRLLQPEYCPDPLYEVMLK-CWHPKAEMRPSFSE 345 >5HLW-A nrPDB Length = 299 Score = 189 bits (479), Expect = 2e-48, Method: Composition-based stats. Identities = 62/275 (22%), Positives = 112/275 (40%), Gaps = 30/275 (10%) Query: 11 VEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTIT---QQNVAIKKLSRPFQNVTHAKR 67 V +G ++ +H IG G G V + + A+K L+R ++ + Sbjct: 13 VVIGPSSLIVHFN----EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNR-ITDIGEVSQ 67 Query: 68 AYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQMDLDHDRM 126 E +MK +H N++ LL L +V+ M +L I+ + + + Sbjct: 68 FLTEGIIMKDFSHPNVLSLLGIC-----LRSEGSPLVVLPYMKHGDLRNFIRNETHNPTV 122 Query: 127 SYLL---YQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTT-----F 178 L+ Q+ G+K+L S +HRDL N ++ T+K+ DFGLAR Sbjct: 123 KDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMHDKEYYSVH 182 Query: 179 MMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGTDHID------Q 231 T + + A E + +T D+WS G ++ E++ G +P + D Q Sbjct: 183 NKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQ 242 Query: 232 WNKIIEQLGTPSPSFMQRLQPTVRNYVENRPRYTG 266 ++++ P P + L+ E RP ++ Sbjct: 243 GRRLLQPEYCPDPLYEVMLK-CWHPKAEMRPSFSE 276 >3G0E-A nrPDB Length = 336 Score = 189 bits (479), Expect = 2e-48, Method: Composition-based stats. Identities = 69/291 (23%), Positives = 113/291 (38%), Gaps = 45/291 (15%) Query: 15 DTNFTIH-SRYINLRPIGSGAQGIVCAA-----YDTITQQNVAIKKLSRPFQNVTHAKRA 68 D + +R + +G+GA G V A + VA+K L +P ++T + Sbjct: 38 DHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKML-KPSAHLTEREAL 96 Query: 69 YREFKLMKLV-NHKNIIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQMDLDH--- 123 E K++ + NH NI+ LL A T ++ E +L ++ D Sbjct: 97 MSELKVLSYLGNHMNIVNLLGACT------IGGPTLVITEYCCYGDLLNFLRRKRDSFIC 150 Query: 124 -----------------DRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKIL 166 + + YQ+ G+ L S IHRDL NI++ KI Sbjct: 151 SKTSPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKIC 210 Query: 167 DFGLARTAGTTFMM---TPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIR-GGVL 222 DFGLAR + + APE I YT D+WS G + E+ G Sbjct: 211 DFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSP 270 Query: 223 FPGTDHIDQWNKIIE---QLGTP--SPSFMQRLQPTVRN-YVENRPRYTGY 267 +PG ++ K+I+ ++ +P +P+ M + T + RP + Sbjct: 271 YPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQI 321 >4R7H-A nrPDB Length = 343 Score = 189 bits (479), Expect = 2e-48, Method: Composition-based stats. Identities = 59/277 (21%), Positives = 103/277 (37%), Gaps = 37/277 (13%) Query: 28 RPIGSGAQGIVCAAYDTITQQN-----VAIKKLSRPFQNVTHAKRAYREFKLMKLV-NHK 81 + +G+GA G V A + VA+K L + + + E K+M + H+ Sbjct: 56 KTLGAGAFGKVVEATAFGLGKEDAVLKVAVKML-KSTAHADEKEALMSELKIMSHLGQHE 114 Query: 82 NIIGLLNAFTPQRNLEEFQDVYLVMELMD--------------------ANLCQVIQMDL 121 NI+ LL A T + + +L++ L + L Sbjct: 115 NIVNLLGACTHGGPVLVITEYCTYGDLLNFLRRKAEAMLGPSLSPGQDPEGLDKEDGRPL 174 Query: 122 DHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMM- 180 + + + Q+ G+ L S IHRD+ N+++ KI DFGLAR Sbjct: 175 ELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYI 234 Query: 181 --TPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQWNKIIE 237 + + APE I YT D+WS G ++ E+ G +PG ++ K+++ Sbjct: 235 VKGNARLPVKWMAPESIFDSVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVK 294 Query: 238 ------QLGTPSPSFMQRLQPTVRNYVENRPRYTGYS 268 Q + +Q +RP + + Sbjct: 295 DGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQIT 331 >4LFI-A nrPDB Length = 374 Score = 188 bits (477), Expect = 4e-48, Method: Composition-based stats. Identities = 68/363 (18%), Positives = 145/363 (39%), Gaps = 50/363 (13%) Query: 5 QHQHYTVEVGDTNFTIHSR-YINLRPIGSGAQGIVCAAYDTITQQNVAI----------- 52 +++ E +++ +++ Y +G G V ++ + I Sbjct: 22 TEEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKI 81 Query: 53 -------------KKLSRPFQNVTHAKRAYREFKLMKLVN----------HKNIIGLLNA 89 K ++ ++K + H NII L + Sbjct: 82 KREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDI 141 Query: 90 FTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRD 149 + LV E +D +++ L + + ++++L + + HS GI+HRD Sbjct: 142 IKDPISKTPA----LVFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRD 197 Query: 150 LKPSNIVVKA-DCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVIL-GMGYTENVDIW 207 +KP N+++ + L+++D+GLA V +R+++ PE+++ Y ++D+W Sbjct: 198 VKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLW 257 Query: 208 SVGCIMGEM-IRGGVLFPGTDHIDQWNKIIEQLGTPS-PSFMQRLQPTVRNYVENRPRYT 265 S G ++ M + F GT + DQ KI++ LGT ++ + + T+ + +Y Sbjct: 258 SFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYI 317 Query: 266 GYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEYINVWYD 325 + R DG N + +L+ +L D ++R++ EA+ H + + Sbjct: 318 RKPWHRFINDGNKHLSGN-------DEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIRE 370 Query: 326 AEE 328 E Sbjct: 371 QIE 373 >3IO7-A nrPDB Length = 313 Score = 187 bits (475), Expect = 6e-48, Method: Composition-based stats. Identities = 59/277 (21%), Positives = 104/277 (37%), Gaps = 41/277 (14%) Query: 27 LRPIGSGAQGIVCAAYDTI----TQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKN 82 L+ +G G G V T + VA+KKL + H + RE +++K + H N Sbjct: 33 LQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEE--HLRDFEREIEILKSLQHDN 90 Query: 83 IIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQM---DLDHDRMSYLLYQMLCGIK 138 I+ L+ME + +L +Q +DH ++ Q+ G++ Sbjct: 91 IVKYKGVCYSAGRRNLK----LIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGME 146 Query: 139 HLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMT----PYVVTRYYRAPEV 194 +L + IHRDL NI+V+ + +KI DFGL + P ++ APE Sbjct: 147 YLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPES 206 Query: 195 ILGMGYTENVDIWSVGCIMGEMIRG-----GVL-----------------FPGTDHIDQW 232 + ++ D+WS G ++ E+ F + + Sbjct: 207 LTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNN 266 Query: 233 NKIIEQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSF 269 ++ G P +M + N V RP + + Sbjct: 267 GRLPRPDGCPDEIYMI-MTECWNNNVNQRPSFRDLAL 302 >4XLV-A nrPDB Length = 328 Score = 187 bits (475), Expect = 6e-48, Method: Composition-based stats. Identities = 61/339 (17%), Positives = 111/339 (32%), Gaps = 77/339 (22%) Query: 10 TVEVGDTNFTIHSRYINLRPIGSGAQGIVCA--AYDTITQQ---NVAIKKLSRPFQNVTH 64 +V V D + LR +G G+ G+V A D I + VA+K ++ ++ Sbjct: 27 SVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESA-SLRE 85 Query: 65 AKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELM-DANLCQVIQMDLDH 123 E +MK +++ LL + Q +VMELM +L ++ Sbjct: 86 RIEFLNEASVMKGFTCHHVVRLLGVVSK------GQPTLVVMELMAHGDLKSYLRSLRPE 139 Query: 124 ------------DRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLA 171 M + ++ G+ +L++ +HRDL N +V D T+KI DFG+ Sbjct: 140 AENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMT 199 Query: 172 RTA-GTTFMMTPYVV--TRYYRAPEVILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGTD 227 R T + + APE + +T + D+WS G ++ E+ + G Sbjct: 200 RDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLS 259 Query: 228 HIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSR 287 + +++ P Sbjct: 260 NEQVLKFVMDGGYLDQPD------------------------------------------ 277 Query: 288 RKASDARNLLSKMLVIDPEQRISVDEALK------HEYI 320 +L+ +P R + E + H Sbjct: 278 NCPERVTDLMRMCWQFNPNMRPTFLEIVNLLKDDLHPSF 316 >4HZS-A nrPDB Length = 341 Score = 187 bits (475), Expect = 6e-48, Method: Composition-based stats. Identities = 64/279 (22%), Positives = 104/279 (37%), Gaps = 32/279 (11%) Query: 5 QHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAA-YDTITQQNV--AIKKLSRPFQN 61 Q T +G+ + + L +G G+ G+V +D + + V A+K L + Sbjct: 1 GSQSLTCLIGEKDLRL------LEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLS 54 Query: 62 VTHA-KRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQM 119 A RE M ++H+N+I L +V EL +L ++ Sbjct: 55 QPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPPMK-------MVTELAPLGSLLDRLRK 107 Query: 120 DLDH---DRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTA-- 174 H +S Q+ G+ +L S IHRDL N+++ +KI DFGL R Sbjct: 108 HQGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQ 167 Query: 175 --GTTFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQ 231 M V + APE + ++ D W G + EM G + G + Sbjct: 168 NDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQI 227 Query: 232 WNKI-IEQLGTPSPS-----FMQRLQPTVRNYVENRPRY 264 +KI E P P + + E+RP + Sbjct: 228 LHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTF 266 >3HMP-A nrPDB Length = 342 Score = 187 bits (475), Expect = 6e-48, Method: Composition-based stats. Identities = 76/321 (23%), Positives = 120/321 (37%), Gaps = 66/321 (20%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVN-HKN 82 Y L+ IGSG V + +Q AIK ++ + E + + H + Sbjct: 58 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 116 Query: 83 -IIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMD--LDHDRMSYLLYQMLCGIKH 139 II L + Q +Y+VME + +L ++ +D ML + Sbjct: 117 KIIRLYDYEITD------QYIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHT 170 Query: 140 LHSAGIIHRDLKPSNIVVKADCTLKILDFGLA---RTAGTTFMMTPYVVTRYYRAPEVIL 196 +H GI+H DLKP+N ++ D LK++DFG+A + T+ + V T Y PE I Sbjct: 171 IHQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIK 229 Query: 197 GMGYTEN-----------VDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPS 245 M + D+WS+GCI+ M G F +II Q+ Sbjct: 230 DMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ---------QIINQI------ 274 Query: 246 FMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDP 305 + PN + D +++L L DP Sbjct: 275 -------------------------SKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDP 309 Query: 306 EQRISVDEALKHEYINVWYDA 326 +QRIS+ E L H Y+ + Sbjct: 310 KQRISIPELLAHPYVQIQTHP 330 >3UIU-A nrPDB Length = 306 Score = 187 bits (475), Expect = 7e-48, Method: Composition-based stats. Identities = 63/235 (26%), Positives = 102/235 (43%), Gaps = 38/235 (16%) Query: 15 DTNFTIHSRY----INLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYR 70 +T +T+ R+ + IGSG G V A I + I+++ + ++A R Sbjct: 1 ETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIRRVKY------NNEKAER 54 Query: 71 EFKLMKLVNHKNIIGLLNAF--------TPQRNLEEFQD---------------VYLVME 107 E K + ++H NI+ + T +LE +++ ME Sbjct: 55 EVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQME 114 Query: 108 LMD-ANLCQVIQM----DLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCT 162 D L Q I+ LD L Q+ G+ ++HS +IHRDLKPSNI + Sbjct: 115 FCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQ 174 Query: 163 LKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMI 217 +KI DFGL + T T Y +PE I Y + VD++++G I+ E++ Sbjct: 175 VKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELL 229 >3PP0-A nrPDB Length = 338 Score = 187 bits (475), Expect = 7e-48, Method: Composition-based stats. Identities = 71/299 (23%), Positives = 110/299 (36%), Gaps = 28/299 (9%) Query: 26 NLRPIGSGAQGIVCAAYDTITQQNV----AIKKLSRPFQNVTHAKRAYREFKLMKLVNHK 81 ++ +GSGA G V +NV AIK L R + K E +M V Sbjct: 21 KVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVL-RENTSPKANKEILDEAYVMAGVGSP 79 Query: 82 NIIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQM---DLDHDRMSYLLYQMLCGI 137 + LL V LV +LM L ++ L + Q+ G+ Sbjct: 80 YVSRLLGICLTS-------TVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGM 132 Query: 138 KHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAG---TTFMMTPYVVTRYYRAPEV 194 +L ++HRDL N++VK+ +KI DFGLAR T + V + A E Sbjct: 133 SYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALES 192 Query: 195 ILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQWNKIIEQLGTPSPSF-----MQ 248 IL +T D+WS G + E++ G + G + + + + P P Sbjct: 193 ILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYM 252 Query: 249 RLQPTVRNYVENRPRYTGY--SFDRLFPDGL-FPNDNNQNSRRKASDARNLLSKMLVID 304 + E RPR+ F R+ D F N++ + +L D Sbjct: 253 IMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDD 311 >6FEX-A nrPDB Length = 321 Score = 187 bits (475), Expect = 7e-48, Method: Composition-based stats. Identities = 61/295 (20%), Positives = 102/295 (34%), Gaps = 56/295 (18%) Query: 21 HSRYINLRPIGSGAQGIVCAAY--------------DTITQQ--NVAIKKLSRPFQNVTH 64 SR +G G G V + VA+K L RP Sbjct: 15 RSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKIL-RPDATKNA 73 Query: 65 AKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQMDLDH 123 +E K+M + NII LL + ++ + M+ +L Q + Sbjct: 74 RNDFLKEVKIMSRLKDPNIIRLLGVCVQD------DPLCMITDYMENGDLNQFLSAHQLE 127 Query: 124 DRMS---------------YLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDF 168 D+ + ++ Q+ G+++L + +HRDL N +V + T+KI DF Sbjct: 128 DKAAEGAPGDPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADF 187 Query: 169 GLARTA--GTTFMMTPYVVTR-YYRAPEVILGMGYTENVDIWSVGCIMGE--MIRGGVLF 223 G++R G + + V + A E IL +T D+W+ G + E M+ F Sbjct: 188 GMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPF 247 Query: 224 -----------PGTDHIDQWNKIIEQLGTPSPSFMQRLQ-PTVRNYVENRPRYTG 266 G DQ ++ P + L E RP ++ Sbjct: 248 GQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQ 302 >5FM2-A nrPDB Length = 355 Score = 187 bits (474), Expect = 9e-48, Method: Composition-based stats. Identities = 60/298 (20%), Positives = 111/298 (37%), Gaps = 49/298 (16%) Query: 15 DTNFTIHSRYINL-RPIGSGAQGIVCAA-----YDTITQQNVAIKKLSRPFQNVTHAKRA 68 D + + + L + +G G G V A VA+K L + + + + Sbjct: 56 DPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKML-KENASPSELRDL 114 Query: 69 YREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVI----------- 117 EF ++K VNH ++I L A + + L++E + Sbjct: 115 LSEFNVLKQVNHPHVIKLYGACSQDG------PLLLIVEYAKYGSLRGFLRESRKVGPGY 168 Query: 118 ----------------QMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADC 161 + L + +Q+ G+++L ++HRDL NI+V Sbjct: 169 LGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGR 228 Query: 162 TLKILDFGLARTA---GTTFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIR 218 +KI DFGL+R + + + + A E + YT D+WS G ++ E++ Sbjct: 229 KMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVT 288 Query: 219 -GGVLFPGTDHIDQWNKI-----IEQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFD 270 GG +PG +N + +E+ S + + + + RP + S D Sbjct: 289 LGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKD 346 >5UUU-A nrPDB Length = 547 Score = 186 bits (473), Expect = 1e-47, Method: Composition-based stats. Identities = 66/310 (21%), Positives = 121/310 (39%), Gaps = 37/310 (11%) Query: 15 DTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKR-AYREFK 73 + + T++ + R IG G G V T + A+K L + + + A E Sbjct: 192 NIHLTMND-FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERI 250 Query: 74 LMKLV---NHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMD---LDHDRMS 127 ++ LV + I+ + AF L +++LM+ M Sbjct: 251 MLSLVSTGDCPFIVCMSYAFHTPDKLS------FILDLMNGGDLHYHLSQHGVFSEADMR 304 Query: 128 YLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTR 187 + +++ G++H+H+ +++RDLKP+NI++ ++I D GLA V T Sbjct: 305 FYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHAS-VGTH 363 Query: 188 YYRAPEVIL-GMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHID-------QWNKIIEQL 239 Y APEV+ G+ Y + D +S+GC++ +++RG F D +E Sbjct: 364 GYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELP 423 Query: 240 GTPSPSFMQRLQPTVRNYVENR--------------PRYTGYSFDRLFPDGLFPNDNNQN 285 + SP L+ ++ V R P + + +F P Sbjct: 424 DSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPR 483 Query: 286 SRRKASDARN 295 A+DA + Sbjct: 484 GEVNAADAFD 493 >3PLS-A nrPDB Length = 298 Score = 186 bits (473), Expect = 1e-47, Method: Composition-based stats. Identities = 61/255 (23%), Positives = 102/255 (40%), Gaps = 22/255 (8%) Query: 28 RPIGSGAQGIVCAAYDTITQQ---NVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNII 84 R IG G G+V Q AIK LSR + + + RE LM+ +NH N++ Sbjct: 27 RVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITE-MQQVEAFLREGLLMRGLNHPNVL 85 Query: 85 GLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLL---YQMLCGIKHLH 141 L+ P L Y+ +L Q I+ + + L+ Q+ G+++L Sbjct: 86 ALIGIMLPPEGLPHVLLPYM----CHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLA 141 Query: 142 SAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMT-----PYVVTRYYRAPEVIL 196 +HRDL N ++ T+K+ DFGLAR + + + A E + Sbjct: 142 EQKFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWTALESLQ 201 Query: 197 GMGYTENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQWNKIIEQLGTPSPSF-----MQRL 250 +T D+WS G ++ E++ G + D D + + + P P + Q + Sbjct: 202 TYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSLYQVM 261 Query: 251 QPTVRNYVENRPRYT 265 Q RP + Sbjct: 262 QQCWEADPAVRPTFR 276 >5GNK-A nrPDB Length = 297 Score = 186 bits (472), Expect = 1e-47, Method: Composition-based stats. Identities = 66/260 (25%), Positives = 109/260 (41%), Gaps = 25/260 (9%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNV----AIKKLSRPFQNVTHAKRAYREFKLMKLVN 79 + ++ +GSGA G V + V AIK+L + K E +M V+ Sbjct: 21 FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREAT-SPKANKEILDEAYVMASVD 79 Query: 80 HKNIIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQMDLDHDRMSYLL---YQMLC 135 + ++ LL V L+M+LM L ++ D+ YLL Q+ Sbjct: 80 NPHVCRLLGICLTS-------TVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAK 132 Query: 136 GIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGT---TFMMTPYVVTRYYRAP 192 G+ +L ++HRDL N++VK +KI DFGLA+ G + V + A Sbjct: 133 GMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMAL 192 Query: 193 EVILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGT--DHIDQWNKIIEQLGTPSPSFMQR 249 E IL YT D+WS G + E++ G + G I + E+L P + Sbjct: 193 ESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDV 252 Query: 250 LQPTVRNYV---ENRPRYTG 266 V+ ++ ++RP++ Sbjct: 253 YMIMVKCWMIDADSRPKFRE 272 >3PVW-A nrPDB Length = 695 Score = 186 bits (472), Expect = 2e-47, Method: Composition-based stats. Identities = 66/310 (21%), Positives = 121/310 (39%), Gaps = 37/310 (11%) Query: 15 DTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKR-AYREFK 73 + + T++ + R IG G G V T + A+K L + + + A E Sbjct: 183 NIHLTMND-FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERI 241 Query: 74 LMKLV---NHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMD---LDHDRMS 127 ++ LV + I+ + AF L +++LM+ M Sbjct: 242 MLSLVSTGDCPFIVCMSYAFHTPDKLS------FILDLMNGGDLHYHLSQHGVFSEADMR 295 Query: 128 YLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTR 187 + +++ G++H+H+ +++RDLKP+NI++ ++I D GLA V T Sbjct: 296 FYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHAS-VGTH 354 Query: 188 YYRAPEVIL-GMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHID-------QWNKIIEQL 239 Y APEV+ G+ Y + D +S+GC++ +++RG F D +E Sbjct: 355 GYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELP 414 Query: 240 GTPSPSFMQRLQPTVRNYVENR--------------PRYTGYSFDRLFPDGLFPNDNNQN 285 + SP L+ ++ V R P + + +F P Sbjct: 415 DSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPR 474 Query: 286 SRRKASDARN 295 A+DA + Sbjct: 475 GEVNAADAFD 484 >1U54-B nrPDB Length = 291 Score = 185 bits (471), Expect = 2e-47, Method: Composition-based stats. Identities = 64/279 (22%), Positives = 104/279 (37%), Gaps = 32/279 (11%) Query: 5 QHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAA-YDTITQQNV--AIKKLSRPFQN 61 Q T +G+ + + L +G G+ G+V +D + + V A+K L + Sbjct: 7 PLQSLTCLIGEKDLRL------LEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLS 60 Query: 62 VTHA-KRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQM 119 A RE M ++H+N+I L +V EL +L ++ Sbjct: 61 QPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPPMK-------MVTELAPLGSLLDRLRK 113 Query: 120 DLDH---DRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTA-- 174 H +S Q+ G+ +L S IHRDL N+++ +KI DFGL R Sbjct: 114 HQGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQ 173 Query: 175 --GTTFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQ 231 M V + APE + ++ D W G + EM G + G + Sbjct: 174 NDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQI 233 Query: 232 WNKI-IEQLGTPSPS-----FMQRLQPTVRNYVENRPRY 264 +KI E P P + + E+RP + Sbjct: 234 LHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTF 272 >3LZB-A nrPDB Length = 327 Score = 185 bits (471), Expect = 2e-47, Method: Composition-based stats. Identities = 62/260 (23%), Positives = 105/260 (40%), Gaps = 25/260 (9%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNV----AIKKLSRPFQNVTHAKRAYREFKLMKLVN 79 + ++ +GSGA G V + V AIK+L + K E +M V+ Sbjct: 17 FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREAT-SPKANKEILDEAYVMASVD 75 Query: 80 HKNIIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQMDLDHDRMSYLL---YQMLC 135 + ++ LL V L+ +LM L ++ D+ YLL Q+ Sbjct: 76 NPHVCRLLGICLTS-------TVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAK 128 Query: 136 GIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGT---TFMMTPYVVTRYYRAP 192 G+ +L ++HRDL N++VK +KI DFGLA+ G + V + A Sbjct: 129 GMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMAL 188 Query: 193 EVILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQWNKIIEQLGTPSPSF----- 246 E IL YT D+WS G + E++ G + G + + + + P P Sbjct: 189 ESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDV 248 Query: 247 MQRLQPTVRNYVENRPRYTG 266 ++ ++RP++ Sbjct: 249 YMIMRKCWMIDADSRPKFRE 268 >5UIU-A nrPDB Length = 323 Score = 185 bits (470), Expect = 2e-47, Method: Composition-based stats. Identities = 72/243 (29%), Positives = 103/243 (42%), Gaps = 35/243 (14%) Query: 5 QHQHYTVEVGDTNFTIHSRYINL--------RPI-------GSGAQGIVCAAYDTITQQN 49 Q ++ ++EV DT F S Y RPI G G G+V Y + Sbjct: 15 QGENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGY--VNNTT 72 Query: 50 VAIKKLSRPFQNVTHA--KRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVME 107 VA+KKL+ T ++ +E K+M H+N++ LL + D+ LV Sbjct: 73 VAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGF------SSDGDDLCLVYV 126 Query: 108 LM-DANLCQVIQ-----MDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADC 161 M + +L + L + GI LH IHRD+K +NI++ Sbjct: 127 YMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAF 186 Query: 162 TLKILDFGLAR---TAGTTFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIR 218 T KI DFGLAR T M + V T Y APE + G T DI+S G ++ E+I Sbjct: 187 TAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEI-TPKSDIYSFGVVLLEIIT 245 Query: 219 GGV 221 G Sbjct: 246 GLP 248 >3I81-A nrPDB Length = 315 Score = 185 bits (470), Expect = 3e-47, Method: Composition-based stats. Identities = 55/282 (19%), Positives = 105/282 (37%), Gaps = 34/282 (12%) Query: 10 TVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDT-----ITQQNVAIKKLSRPFQNVTH 64 V V D + R +G G+ G+V + VAIK ++ ++ Sbjct: 6 DVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAA-SMRE 64 Query: 65 AKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELM-DANLCQVIQMDLDH 123 E +MK N +++ LL + Q ++MELM +L ++ Sbjct: 65 RIEFLNEASVMKEFNCHHVVRLLGVVSQ------GQPTLVIMELMTRGDLKSYLRSLRPE 118 Query: 124 ------------DRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLA 171 +M + ++ G+ +L++ +HRDL N +V D T+KI DFG+ Sbjct: 119 MENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMT 178 Query: 172 RTA-GTTFMMTPYVV--TRYYRAPEVILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGTD 227 R T + + +PE + +T D+WS G ++ E+ + G Sbjct: 179 RDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLS 238 Query: 228 HIDQWNKIIEQLGTPSPS-----FMQRLQPTVRNYVENRPRY 264 + ++E P + ++ + + RP + Sbjct: 239 NEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSF 280 >6CTH-A nrPDB Length = 309 Score = 185 bits (470), Expect = 3e-47, Method: Composition-based stats. Identities = 53/210 (25%), Positives = 93/210 (44%), Gaps = 17/210 (8%) Query: 20 IHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVN 79 + S + +G G G V + + +A+KK+SR + K E K++ + Sbjct: 13 VTSNFNAENKLGEGGFGSVYRGFLRDSDTYIAVKKVSRASKQG--IKEYASEVKIISRLR 70 Query: 80 HKNIIGLLNAFTPQRNLEEFQDVYLVMELM-DANLCQVI---QMDLDHDRMSYLLYQMLC 135 HKN++ L+ E ++ LV E M + +L I + L + ++ + Sbjct: 71 HKNLVKLIGWC------HERGELMLVYEFMANGSLDSHIFKGKSLLTWEVRYRIVKDLAS 124 Query: 136 GIKHLHSAG---IIHRDLKPSNIVVKADCTLKILDFGLARTAGT--TFMMTPYVVTRYYR 190 + +LH G ++HRD+K SNI++ + K+ DFGLAR T T Y Sbjct: 125 ALLYLHEEGDHCVLHRDIKTSNIMLDSSFNAKLGDFGLARLVDHAKGLKKTLLAGTVGYM 184 Query: 191 APEVILGMGYTENVDIWSVGCIMGEMIRGG 220 APE + ++ D++S G + E+ G Sbjct: 185 APECLSSGKASKESDVYSFGVVALEIASGR 214 >5GRN-A nrPDB Length = 356 Score = 185 bits (469), Expect = 3e-47, Method: Composition-based stats. Identities = 68/327 (20%), Positives = 117/327 (35%), Gaps = 53/327 (16%) Query: 15 DTNFTIHSRYINL-RPIGSGAQGIVCAAYDTITQQ-----NVAIKKLSRPFQNVTHAKRA 68 D+ + + L R +GSGA G V + VA+K L +P + + Sbjct: 38 DSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKML-KPTARSSEKQAL 96 Query: 69 YREFKLMKLVN-HKNIIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQMD------ 120 E K+M + H NI+ LL A T +Y++ E +L + + Sbjct: 97 MSELKIMTHLGPHLNIVNLLGACTKSG------PIYIITEYCFYGDLVNYLHKNRDSFLS 150 Query: 121 ----------------------LDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK 158 L + YQ+ G++ L S +HRDL N+++ Sbjct: 151 HKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLA 210 Query: 159 ADCTLKILDFGLARTAGTTFMMTPYVVT---RYYRAPEVILGMGYTENVDIWSVGCIMGE 215 +KI DFGLAR T + APE I YT D+WS G ++ E Sbjct: 211 QGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWE 270 Query: 216 MIR-GGVLFPGTDHIDQWNKIIE---QLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDR 271 + GG +PG + I+ ++ P + + + V+ + + + Sbjct: 271 IFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLS 330 Query: 272 LFPDGLFPNDNNQNSRRKASDARNLLS 298 + L P ++ + + L Sbjct: 331 EIVENLLPGQYKKSYEKIH---LDFLK 354 >6BSD-A nrPDB Length = 876 Score = 185 bits (469), Expect = 4e-47, Method: Composition-based stats. Identities = 61/301 (20%), Positives = 102/301 (33%), Gaps = 62/301 (20%) Query: 21 HSRYINLRPIGSGAQGIVCAAY--------------DTITQQ--NVAIKKLSRPFQNVTH 64 SR +G G G V + VA+K L RP Sbjct: 570 RSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKIL-RPDATKNA 628 Query: 65 AKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQMDLDH 123 +E K+M + NII LL + ++ + M+ +L Q + Sbjct: 629 RNDFLKEVKIMSRLKDPNIIRLLGVCVQD------DPLCMITDYMENGDLNQFLSAHQLE 682 Query: 124 DRMS---------------------YLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCT 162 D+ + ++ Q+ G+++L + +HRDL N +V + T Sbjct: 683 DKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFT 742 Query: 163 LKILDFGLARTA--GTTFMMTPYVVTR-YYRAPEVILGMGYTENVDIWSVGCIMGE--MI 217 +KI DFG++R G + + V + A E IL +T D+W+ G + E M+ Sbjct: 743 IKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLML 802 Query: 218 RGGVLF-----------PGTDHIDQWNKIIEQLGTPSPSFMQRLQ-PTVRNYVENRPRYT 265 F G DQ ++ P + L E RP ++ Sbjct: 803 CRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFS 862 Query: 266 G 266 Sbjct: 863 Q 863 >2ZMD-A nrPDB Length = 390 Score = 184 bits (468), Expect = 4e-47, Method: Composition-based stats. Identities = 75/321 (23%), Positives = 119/321 (37%), Gaps = 66/321 (20%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVN-HKN 82 Y L+ IGSG V + +Q AIK ++ + E + + H + Sbjct: 58 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 116 Query: 83 -IIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMD--LDHDRMSYLLYQMLCGIKH 139 II L + Q +Y+VME + +L ++ +D ML + Sbjct: 117 KIIRLYDYEITD------QYIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHT 170 Query: 140 LHSAGIIHRDLKPSNIVVKADCTLKILDFGLA---RTAGTTFMMTPYVVTRYYRAPEVIL 196 +H GI+H DLKP+N ++ D LK++DFG+A + T+ + V Y PE I Sbjct: 171 IHQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGAVNYMPPEAIK 229 Query: 197 GMGYTEN-----------VDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPS 245 M + D+WS+GCI+ M G F +II Q+ Sbjct: 230 DMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ---------QIINQI------ 274 Query: 246 FMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDP 305 + PN + D +++L L DP Sbjct: 275 -------------------------SKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDP 309 Query: 306 EQRISVDEALKHEYINVWYDA 326 +QRIS+ E L H Y+ + Sbjct: 310 KQRISIPELLAHPYVQIQTHP 330 >5TUR-A nrPDB Length = 404 Score = 184 bits (468), Expect = 4e-47, Method: Composition-based stats. Identities = 67/328 (20%), Positives = 121/328 (36%), Gaps = 68/328 (20%) Query: 14 GDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRP----FQNVTHAKRAY 69 G + S+Y +GSG G V + VAIK + + + + + R Sbjct: 119 GKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVP 178 Query: 70 REFKLMKLVNHKN--IIGLLNAFTPQRNLEEFQDVYLVMELMDA--NLCQVI--QMDLDH 123 E L+K V+ +I LL+ F + L++E + +L I + L Sbjct: 179 MEVVLLKKVSSGFSGVIRLLDWFERPDSF------VLILERPEPVQDLFDFITERGALQE 232 Query: 124 DRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-ADCTLKILDFGLARTAGTTFMMTP 182 + +Q+L ++H H+ G++HRD+K NI++ LK++DFG T + T Sbjct: 233 ELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDT-VYTD 291 Query: 183 YVVTRYYRAPEVILGMGY-TENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGT 241 + TR Y PE I Y + +WS+G ++ +M+ G + F Sbjct: 292 FDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFE----------------- 334 Query: 242 PSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKML 301 D +R +S+ ++L+ L Sbjct: 335 --------------------------------HDEEIIRGQVFFRQRVSSECQHLIRWCL 362 Query: 302 VIDPEQRISVDEALKHEYINVWYDAEEV 329 + P R + +E H ++ +E Sbjct: 363 ALRPSDRPTFEEIQNHPWMQDVLLPQET 390 >5HVK-A nrPDB Length = 315 Score = 184 bits (467), Expect = 5e-47, Method: Composition-based stats. Identities = 57/267 (21%), Positives = 97/267 (36%), Gaps = 34/267 (12%) Query: 28 RPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLL 87 +G G G T + + +K+L R + + +E K+M+ + H N++ + Sbjct: 20 EVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQ--RTFLKEVKVMRCLEHPNVLKFI 77 Query: 88 NAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLD----HDRMSYLLYQMLCGIKHLHSA 143 + L + E + + I +D + + G+ +LHS Sbjct: 78 GVLYKDKRLN------FITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSM 131 Query: 144 GIIHRDLKPSNIVVKADCTLKILDFGLARTA---------------GTTFMMTPYVVTRY 188 IIHR+L N +V+ + + + DFGLAR V Y Sbjct: 132 NIIHRNLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPY 191 Query: 189 YRAPEVILGMGYTENVDIWSVGCIMGEMIRG-----GVLFPGTDHIDQWNKIIEQLGTP- 242 + APE+I G Y E VD++S G ++ E+I L D +++ P Sbjct: 192 WMAPEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPPN 251 Query: 243 -SPSFMQRLQPTVRNYVENRPRYTGYS 268 PSF E RP + Sbjct: 252 CPPSFFPITVRCCDLDPEKRPSFVKLE 278 >4TPT-A nrPDB Length = 303 Score = 184 bits (467), Expect = 6e-47, Method: Composition-based stats. Identities = 61/273 (22%), Positives = 103/273 (37%), Gaps = 41/273 (15%) Query: 28 RPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLL 87 +G G G T + + +K+L R + K E K+M+ ++H N++ + Sbjct: 6 EVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQ--KTFLTEVKVMRSLDHPNVLKFI 63 Query: 88 NAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLD---HDRMSYLLYQMLCGIKHLHSAG 144 + L L+ E ++ + +D + + G+ +LHS Sbjct: 64 GVLYKDKKLN------LLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMAYLHSMC 117 Query: 145 IIHRDLKPSNIVVKADCTLKILDFGLARTA---------------------GTTFMMTPY 183 IIHRDL N ++K D T+ + DFGL+R Sbjct: 118 IIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTV 177 Query: 184 VVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWN-----KIIEQ 238 V Y+ APE++ G Y E VDI+S G ++ E+I G V + K+ + Sbjct: 178 VGNPYWMAPEMLNGKSYDETVDIFSFGIVLCEII-GQVYADPDCLPRTLDFGLNVKLFWE 236 Query: 239 LGTP---SPSFMQRLQPTVRNYVENRPRYTGYS 268 P P+F R E+RP ++ Sbjct: 237 KFVPTDCPPAFFPLAAICCRLEPESRPAFSKLE 269 >3BGP-A nrPDB Length = 333 Score = 184 bits (466), Expect = 7e-47, Method: Composition-based stats. Identities = 67/328 (20%), Positives = 121/328 (36%), Gaps = 68/328 (20%) Query: 14 GDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRP----FQNVTHAKRAY 69 G + S+Y +GSG G V + VAIK + + + + + R Sbjct: 48 GKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVP 107 Query: 70 REFKLMKLVNHKN--IIGLLNAFTPQRNLEEFQDVYLVMELMDA--NLCQVI--QMDLDH 123 E L+K V+ +I LL+ F + L++E + +L I + L Sbjct: 108 MEVVLLKKVSSGFSGVIRLLDWFERPDSF------VLILERPEPVQDLFDFITERGALQE 161 Query: 124 DRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-ADCTLKILDFGLARTAGTTFMMTP 182 + +Q+L ++H H+ G++HRD+K NI++ LK++DFG T + T Sbjct: 162 ELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDT-VYTD 220 Query: 183 YVVTRYYRAPEVILGMGY-TENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGT 241 + TR Y PE I Y + +WS+G ++ +M+ G + F Sbjct: 221 FDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFE----------------- 263 Query: 242 PSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKML 301 D +R +S+ ++L+ L Sbjct: 264 --------------------------------HDEEIIRGQVFFRQRVSSECQHLIRWCL 291 Query: 302 VIDPEQRISVDEALKHEYINVWYDAEEV 329 + P R + +E H ++ +E Sbjct: 292 ALRPSDRPTFEEIQNHPWMQDVLLPQET 319 >3LLT-A nrPDB Length = 360 Score = 184 bits (466), Expect = 8e-47, Method: Composition-based stats. Identities = 68/364 (18%), Positives = 138/364 (37%), Gaps = 56/364 (15%) Query: 2 TTAQHQHYTVEVGDTNFT------IHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKL 55 + ++ ++ + +F+ +++ ++ +R +G G G V ++ A+K + Sbjct: 9 SGRENLYFQGDDEIVHFSWKKGMLLNNAFLVIRKMGDGTFGRVLLCQHIDNKKYYAVKVV 68 Query: 56 SRPFQNVTHAKRAYREFKLMKLVNHKNI-----IGLLNAFTPQRNLEEFQDVYLVMELMD 110 + + + A E ++K + + +I + F + + L+ E + Sbjct: 69 RNIKK---YTRSAKIEADILKKIQNDDINNNNIVKYHGKF------MYYDHMCLIFEPLG 119 Query: 111 ANLCQVIQMD----LDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCT---- 162 +L ++I + + + ++L + +L + H DLKP NI++ Sbjct: 120 PSLYEIITRNNYNGFHIEDIKLYCIEILKALNYLRKMSLTHTDLKPENILLDDPYFEKSL 179 Query: 163 ---------------------LKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGYT 201 +K++DFG A + TR YRAPEVIL +G+ Sbjct: 180 ITVRRVTDGKKIQIYRTKSTGIKLIDFGCATFKSDYH--GSIINTRQYRAPEVILNLGWD 237 Query: 202 ENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENR 261 + D+WS GC++ E+ G +LF +H++ ++E + P P M Sbjct: 238 VSSDMWSFGCVLAELYTGSLLFRTHEHMEHL-AMMESIIQPIPKNMLYEATKTNGSKYVN 296 Query: 262 PRYTGYSFDRLFPD----GLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKH 317 ++ K + L +L IDP R S E LKH Sbjct: 297 KDELKLAWPENASSINSIKHVKKCLPLYKIIKHELFCDFLYSILQIDPTLRPSPAELLKH 356 Query: 318 EYIN 321 +++ Sbjct: 357 KFLE 360 >5U6C-A nrPDB Length = 315 Score = 183 bits (465), Expect = 8e-47, Method: Composition-based stats. Identities = 47/262 (17%), Positives = 98/262 (37%), Gaps = 22/262 (8%) Query: 25 INLRPIGSGAQGIVCAAYDTI---TQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHK 81 I + +G G G V T VA+K + + + E MK +H Sbjct: 39 ILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHP 98 Query: 82 NIIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVI--------QMDLDHDRMSYLLYQ 132 N++ LL + + +++ M +L + + + + Sbjct: 99 NVMRLLGVCIEMSSQGIPKP-MVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVD 157 Query: 133 MLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVV---TRYY 189 + G+++L + +HRDL N +++ D T+ + DFGL++ + + + Sbjct: 158 IALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKW 217 Query: 190 RAPEVILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQWNKIIEQLGTPSP---- 244 A E + YT D+W+ G M E+ G +PG + + ++ ++ P Sbjct: 218 IAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCL 277 Query: 245 -SFMQRLQPTVRNYVENRPRYT 265 + + R +RP ++ Sbjct: 278 DELYEIMYSCWRTDPLDRPTFS 299 >2WTK-B nrPDB Length = 373 Score = 183 bits (464), Expect = 1e-46, Method: Composition-based stats. Identities = 64/335 (19%), Positives = 114/335 (34%), Gaps = 36/335 (10%) Query: 24 YINLRPIGSGAQG---IVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNH 80 Y L IG G V A T + V +++++ + E + KL NH Sbjct: 11 YELLTVIGKG-FEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNH 69 Query: 81 KNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN-----LCQVIQMDLDHDRMSYLLYQMLC 135 NI+ F ++++V M +C ++ ++Y+L +L Sbjct: 70 PNIVPYRATFIADN------ELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLK 123 Query: 136 GIKHLHSAGIIHRDLKPSNIVVKADCTLKI---------LDFGLARTAGTTFMMTPYVVT 186 + ++H G +HR +K S+I++ D + + + G + F V Sbjct: 124 ALDYIHHMGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSVKVL 183 Query: 187 RYYRAPEVILG--MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSP 244 + +PEV+ GY DI+SVG E+ G V F +E+L P Sbjct: 184 P-WLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQML---LEKLNGTVP 239 Query: 245 SFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNS------RRKASDARNLLS 298 + + R S P +N +S R + + + Sbjct: 240 CLLDTSTIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTFSPHFHHFVE 299 Query: 299 KMLVIDPEQRISVDEALKHEYINVWYDAEEVDAPA 333 + L +P+ R S L H + P Sbjct: 300 QCLQRNPDARPSASTLLNHSFFKQIKRRASEALPE 334 >6FER-A nrPDB Length = 309 Score = 182 bits (462), Expect = 2e-46, Method: Composition-based stats. Identities = 59/288 (20%), Positives = 96/288 (33%), Gaps = 53/288 (18%) Query: 28 RPIGSGAQGIVCAAY--------------DTITQQ--NVAIKKLSRPFQNVTHAKRAYRE 71 +G G G V D Q VA+K L R N +E Sbjct: 15 EKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKML-RADANKNARNDFLKE 73 Query: 72 FKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQMDLDHDR----- 125 K+M + NII LL + ++ E M+ +L Q + + Sbjct: 74 IKIMSRLKDPNIIHLLAVCITD------DPLCMITEYMENGDLNQFLSRHEPPNSSSSDV 127 Query: 126 -------MSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTA--GT 176 + ++ Q+ G+K+L S +HRDL N +V + T+KI DFG++R G Sbjct: 128 RTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGD 187 Query: 177 TFMMTPYVVTR-YYRAPEVILGMGYTENVDIWSVGCIMGEMIRG--GVLFPGTDHIDQWN 233 + + V + + E IL +T D+W+ G + E + Sbjct: 188 YYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIE 247 Query: 234 KIIE------------QLGTPSPSFMQRLQPTVRNYVENRPRYTGYSF 269 E Q S + + R +NRP + Sbjct: 248 NTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIHL 295 >4HVI-A nrPDB Length = 314 Score = 182 bits (461), Expect = 3e-46, Method: Composition-based stats. Identities = 49/202 (24%), Positives = 85/202 (42%), Gaps = 18/202 (8%) Query: 30 IGSGAQGIVCAAYDTI----TQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIG 85 +G G G V T VA+K+L + RE +++K ++ I+ Sbjct: 18 LGKGNFGSVELCRYDPLGDNTGALVAVKQLQ--HSGPDQQRDFQREIQILKALHSDFIVK 75 Query: 86 LLNAFTPQRNLEEFQDVYLVMELMDA----NLCQVIQMDLDHDRMSYLLYQMLCGIKHLH 141 Q + LVME + + + Q + LD R+ Q+ G+++L Sbjct: 76 YRGVSYGPGR----QSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLG 131 Query: 142 SAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMT----PYVVTRYYRAPEVILG 197 S +HRDL NI+V+++ +KI DFGLA+ P ++ APE + Sbjct: 132 SRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSD 191 Query: 198 MGYTENVDIWSVGCIMGEMIRG 219 ++ D+WS G ++ E+ Sbjct: 192 NIFSRQSDVWSFGVVLYELFTY 213 >4RC3-A nrPDB Length = 289 Score = 180 bits (457), Expect = 8e-46, Method: Composition-based stats. Identities = 66/322 (20%), Positives = 120/322 (37%), Gaps = 68/322 (21%) Query: 20 IHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRP----FQNVTHAKRAYREFKLM 75 + S+Y +GSG G V + VAIK + + + + + R E L+ Sbjct: 10 LESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLL 69 Query: 76 KLVNHKN--IIGLLNAFTPQRNLEEFQDVYLVMELMDA--NLCQVI--QMDLDHDRMSYL 129 K V+ +I LL+ F + L++E + +L I + L + Sbjct: 70 KKVSSGFSGVIRLLDWFERPDSF------VLILERPEPVQDLFDFITERGALQEELARSF 123 Query: 130 LYQMLCGIKHLHSAGIIHRDLKPSNIVVK-ADCTLKILDFGLARTAGTTFMMTPYVVTRY 188 +Q+L ++H H+ G++HRD+K NI++ LK++DFG T + T + TR Sbjct: 124 FWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDT-VYTDFDGTRV 182 Query: 189 YRAPEVILGMGY-TENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFM 247 Y PE I Y + +WS+G ++ +M+ G + F Sbjct: 183 YSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFE----------------------- 219 Query: 248 QRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQ 307 D +R +S+ ++L+ L + P Sbjct: 220 --------------------------HDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSD 253 Query: 308 RISVDEALKHEYINVWYDAEEV 329 R + +E H ++ +E Sbjct: 254 RPTFEEIQNHPWMQDVLLPQET 275 >4LRM-A nrPDB Length = 334 Score = 180 bits (456), Expect = 1e-45, Method: Composition-based stats. Identities = 65/263 (24%), Positives = 108/263 (41%), Gaps = 28/263 (10%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNV----AIKKLSRPFQNVTHAKRAYREFKLMKLVN 79 + ++ +GSGA G V + V AIK+L + K E +M V+ Sbjct: 21 FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREAT-SPKANKEILDEAYVMASVD 79 Query: 80 HK---NIIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQMDLDHDRMSYLL---YQ 132 + ++ LL V L+ +LM L ++ D+ YLL Q Sbjct: 80 NPGNPHVCRLLGICLTS-------TVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQ 132 Query: 133 MLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGT---TFMMTPYVVTRYY 189 + G+ +L ++HRDL N++VK +KI DFGLA+ G + V + Sbjct: 133 IAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKW 192 Query: 190 RAPEVILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGT--DHIDQWNKIIEQLGTPSPSF 246 A E IL YT D+WS G + E++ G + G I + E+L P Sbjct: 193 MALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICT 252 Query: 247 MQRLQPTVRNYV---ENRPRYTG 266 + V+ ++ ++RP++ Sbjct: 253 IDVYMIMVKCWMIDADSRPKFRE 275 >4Y83-A nrPDB Length = 332 Score = 179 bits (453), Expect = 2e-45, Method: Composition-based stats. Identities = 72/327 (22%), Positives = 126/327 (38%), Gaps = 62/327 (18%) Query: 1 MTTAQHQHYTVEVGDTNFTIHSRYINLRPIGS-----GAQGIVCAAYDTITQQNVAIKKL 55 + T Q+ Y + D++ + + R IGS GA G V A D T++ +A K + Sbjct: 50 VITPQNGRYQI---DSDVLLIPWKLTYRNIGSDFIPRGAFGKVYLAQDIKTKKRMACKLI 106 Query: 56 SRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN-LC 114 + ++ H+NI L A + V+L ME + + Sbjct: 107 PVDQFKPSD-------VEIQACFRHENIAELYGAVL------WGETVHLFMEAGEGGSVL 153 Query: 115 QVIQM--DLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLA- 171 + ++ + + ++ +L G+ LHS +IH D+KPSNIV + + ++DFGL+ Sbjct: 154 EKLESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHHDIKPSNIVFMSTKAV-LVDFGLSV 212 Query: 172 RTAGTTFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQ 231 + + T Y +PEVIL G++ DI+S+G + M G + Sbjct: 213 QMTEDVYFPKDLRGTEIYMSPEVILCRGHSTKADIYSLGATLIHMQTGTPPW-------- 264 Query: 232 WNKIIEQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKAS 291 V+ PR S+ + P ++ + + Sbjct: 265 --------------------------VKRYPRSAYPSYLYIIHKQAPPLEDIAD--DCSP 296 Query: 292 DARNLLSKMLVIDPEQRISVDEALKHE 318 R L+ L +P R + LKHE Sbjct: 297 GMRELIEASLERNPNHRPRAADLLKHE 323 >4JLC-A nrPDB Length = 657 Score = 177 bits (448), Expect = 8e-45, Method: Composition-based stats. Identities = 60/256 (23%), Positives = 97/256 (37%), Gaps = 25/256 (9%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSR-PFQNVTHAKRAYREFKLMKLVNHKN 82 ++ +G GA V T A+K + F + REF+++K +NHKN Sbjct: 10 WLLSDILGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQ--MREFEVLKKLNHKN 67 Query: 83 IIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQ-----MDLDHDRMSYLLYQMLCG 136 I+ L + L+ME +L V++ L +L ++ G Sbjct: 68 IVKLFAI----EEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGG 123 Query: 137 IKHLHSAGIIHRDLKPSNIV--VKADCT--LKILDFGLARTAGTTFMMTPYVVTRYYRAP 192 + HL GI+HRD+KP NI+ + D K+ DFG AR T Y P Sbjct: 124 MNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHP 183 Query: 193 EVIL--------GMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSP 244 ++ Y VD+WSVG G + F + + +++ ++ T P Sbjct: 184 DMYERAVLRKDHQKKYGATVDLWSVGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKP 243 Query: 245 SFMQRLQPTVRNYVEN 260 S N + Sbjct: 244 SGAISGVQKAENGPID 259 >4EUU-A nrPDB Length = 319 Score = 177 bits (448), Expect = 8e-45, Method: Composition-based stats. Identities = 59/256 (23%), Positives = 97/256 (37%), Gaps = 25/256 (9%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSR-PFQNVTHAKRAYREFKLMKLVNHKN 82 ++ +G GA V T AIK + F + REF+++K +NHKN Sbjct: 11 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHKN 68 Query: 83 IIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQ-----MDLDHDRMSYLLYQMLCG 136 I+ L + L+ME +L V++ L +L ++ G Sbjct: 69 IVKLFAI----EEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGG 124 Query: 137 IKHLHSAGIIHRDLKPSNIV--VKADCT--LKILDFGLARTAGTTFMMTPYVVTRYYRAP 192 + HL GI+HR++KP NI+ + D K+ DFG AR T Y P Sbjct: 125 MNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHP 184 Query: 193 EVIL--------GMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSP 244 ++ Y VD+WS+G G + F + + +++ ++ T P Sbjct: 185 DMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKP 244 Query: 245 SFMQRLQPTVRNYVEN 260 S N + Sbjct: 245 SGAISGVQKAENGPID 260 >5VD3-A nrPDB Length = 311 Score = 177 bits (448), Expect = 1e-44, Method: Composition-based stats. Identities = 69/303 (22%), Positives = 108/303 (35%), Gaps = 55/303 (18%) Query: 20 IHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLV- 78 + L +G G+ G V + A+K+ PF+ R E + V Sbjct: 55 FQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVG 114 Query: 79 NHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANL---CQVIQMDLDHDRMSYLLYQMLC 135 H + L ++ EE +YL EL +L C+ L ++ L L Sbjct: 115 QHPCCVRL------EQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLL 168 Query: 136 GIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVI 195 + HLHS G++H D+KP+NI + K+ DFGL GT Y APE++ Sbjct: 169 ALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELL 228 Query: 196 LGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVR 255 G Y D++S+G + E+ L G + Q + G P F L Sbjct: 229 QG-SYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQ-----GYLPPEFTAGL----- 277 Query: 256 NYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEAL 315 +S+ R++L ML DP+ R + + L Sbjct: 278 ----------------------------------SSELRSVLVMMLEPDPKLRATAEALL 303 Query: 316 KHE 318 Sbjct: 304 ALP 306 >4EUT-A nrPDB Length = 396 Score = 175 bits (444), Expect = 2e-44, Method: Composition-based stats. Identities = 59/256 (23%), Positives = 97/256 (37%), Gaps = 25/256 (9%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSR-PFQNVTHAKRAYREFKLMKLVNHKN 82 ++ +G GA V T AIK + F + REF+++K +NHKN Sbjct: 11 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHKN 68 Query: 83 IIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQ-----MDLDHDRMSYLLYQMLCG 136 I+ L + L+ME +L V++ L +L ++ G Sbjct: 69 IVKLFAI----EEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGG 124 Query: 137 IKHLHSAGIIHRDLKPSNIV--VKADCT--LKILDFGLARTAGTTFMMTPYVVTRYYRAP 192 + HL GI+HR++KP NI+ + D K+ DFG AR T Y P Sbjct: 125 MNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHP 184 Query: 193 EVIL--------GMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSP 244 ++ Y VD+WS+G G + F + + +++ ++ T P Sbjct: 185 DMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKP 244 Query: 245 SFMQRLQPTVRNYVEN 260 S N + Sbjct: 245 SGAISGVQKAENGPID 260 >5O0Y-A nrPDB Length = 579 Score = 175 bits (444), Expect = 3e-44, Method: Composition-based stats. Identities = 64/311 (20%), Positives = 114/311 (36%), Gaps = 67/311 (21%) Query: 35 QGIVCAAYDTITQQNVAIKK--LSRPFQNVT---HAKRAYREFKLMKLVNHKNIIGLLNA 89 V A+D Q+ VA+K L++ +++ + K A RE+++ K ++H I+ L + Sbjct: 297 FSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDY 356 Query: 90 FTPQRNLEEFQDVYLVMELMDANLCQVI---QMDLDHDRMSYLLYQMLCGIKHLHSAG-- 144 F+ + V+E + N + ++ Q++ +K+L+ Sbjct: 357 FS-----LDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPP 411 Query: 145 IIHRDLKPSNIVV---KADCTLKILDFGLARTAGTT--------FMMTPYVVTRYYRAPE 193 IIH DLKP NI++ A +KI DFGL++ + + T +Y PE Sbjct: 412 IIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPE 471 Query: 194 VI----LGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQR 249 + VD+WSVG I + + G F G + Q +Q Sbjct: 472 CFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPF-GHNQSQQ-------------DILQE 517 Query: 250 LQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRI 309 V+ P+ +A+ + + L E RI Sbjct: 518 NTILKATEVQFPPK-----------------------PVVTPEAKAFIRRCLAYRKEDRI 554 Query: 310 SVDEALKHEYI 320 V + Y+ Sbjct: 555 DVQQLACDPYL 565 >3AOX-A nrPDB Length = 344 Score = 175 bits (443), Expect = 3e-44, Method: Composition-based stats. Identities = 51/283 (18%), Positives = 98/283 (34%), Gaps = 34/283 (12%) Query: 10 TVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAY-----DTITQQNVAIKKLSRPFQNVTH 64 T + D +R +G GA G V + + VA+K L Sbjct: 35 TSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDE 94 Query: 65 AKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELM-DANLCQVIQ----- 118 E ++ NH+NI+ + ++++ELM +L ++ Sbjct: 95 L-DFLMEALIISKFNHQNIVRCIGVSLQSL------PRFILLELMAGGDLKSFLRETRPR 147 Query: 119 ----MDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCT---LKILDFGLA 171 L + ++ + CG ++L IHRD+ N ++ KI DFG+A Sbjct: 148 PSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMA 207 Query: 172 RTAG-TTFMMTPYVV--TRYYRAPEVILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGTD 227 R ++ + PE + +T D WS G ++ E+ G + +P Sbjct: 208 RDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKS 267 Query: 228 HIDQWNKIIEQLGTPSP-----SFMQRLQPTVRNYVENRPRYT 265 + + + P + + ++ E+RP + Sbjct: 268 NQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFA 310 >4NEU-A nrPDB Length = 333 Score = 174 bits (442), Expect = 5e-44, Method: Composition-based stats. Identities = 59/276 (21%), Positives = 103/276 (37%), Gaps = 35/276 (12%) Query: 21 HSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNH 80 S ++ + SG G V + + +K + + + H + E K+M + H Sbjct: 23 SSDFLESAELDSGGFGKVSLCFHRTQGLMI-MKTVYKGPNCIEHNEALLEEAKMMNRLRH 81 Query: 81 KNIIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQMDLDHDRMS--YLLYQMLCGI 137 ++ LL + LVME M+ NL V++ ++ ++ +++ G+ Sbjct: 82 SRVVKLLGVIIEEGKYS------LVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGM 135 Query: 138 KHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLA------RTAGTTFMMTPYV------- 184 +LH G+IH+DLKP NI+V D +KI D GLA + V Sbjct: 136 CYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKN 195 Query: 185 -VTRYYRAPEVILG--MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGT 241 T YY APE + TE D++S ++ + + Q I+ Sbjct: 196 GGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGNR 255 Query: 242 P---------SPSFMQRLQPTVRNYVENRPRYTGYS 268 P + ++ E RP + G Sbjct: 256 PDVDDITEYCPREIISLMKLCWEANPEARPTFPGIE 291 >4FL3-A nrPDB Length = 635 Score = 173 bits (439), Expect = 9e-44, Method: Composition-based stats. Identities = 63/275 (22%), Positives = 110/275 (40%), Gaps = 24/275 (8%) Query: 12 EVGDTNFTIHSRYINL--RPIGSGAQGIVCAAYDT--ITQQNVAIKKLSRPFQNVTHAKR 67 E+ + + + L + +GSG G V Y + VA+K L + Sbjct: 357 EIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDE 416 Query: 68 AYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQ--MDLDHD 124 E +M+ +++ I+ ++ E + LVME+ + L + +Q + Sbjct: 417 LLAEANVMQQLDNPYIVRMIGIC-------EAESWMLVMEMAELGPLNKYLQQNRHVKDK 469 Query: 125 RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMM---- 180 + L++Q+ G+K+L + +HRDL N+++ KI DFGL++ Sbjct: 470 NIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQ 529 Query: 181 TPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQ--WNKIIE 237 T + APE I ++ D+WS G +M E G + G + + E Sbjct: 530 THGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGE 589 Query: 238 QLGTP--SPSFMQRLQPTVRNY-VENRPRYTGYSF 269 ++G P P M L Y VENRP + Sbjct: 590 RMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVEL 624 >4YFF-A nrPDB Length = 311 Score = 173 bits (439), Expect = 1e-43, Method: Composition-based stats. Identities = 62/269 (23%), Positives = 104/269 (38%), Gaps = 24/269 (8%) Query: 15 DTNFTIH-SRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLS-RPFQNVTHAKRAYREF 72 ++F + S IGSG+ G V + VAIK+ + + + RE Sbjct: 34 PSHFHLQLSEIEFHEIIGSGSFGKVYKGRCR--NKIVAIKRYRANTYCSKSDVDMFCREV 91 Query: 73 KLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN----LCQVIQMDLDHDRMSY 128 ++ +NH +I + A L + +V + + L + LD Sbjct: 92 SILCQLNHPCVIQFVGAC-----LNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLI 146 Query: 129 LLYQMLCGIKHLHS--AGIIHRDLKPSNIVVKADCTLKILDFGLARTAG--TTFMMTPYV 184 + + G+++LH+ IIHRDL NI++ D + DFG +R MT Sbjct: 147 IAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQP 206 Query: 185 VTRYYRAPEVILG-MGYTENVDIWSVGCIMGEMIRGGVLF----PGTDHIDQ-WNKIIEQ 238 + APEV YT D++S + E++ G + F P D ++ I Sbjct: 207 GNLRWMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPP 266 Query: 239 LGTPSPSFMQRLQPTVRNY-VENRPRYTG 266 +G P + L N E RP ++ Sbjct: 267 IGYSIPKPISSLLIRGWNACPEGRPEFSE 295 >4C59-A nrPDB Length = 340 Score = 173 bits (438), Expect = 1e-43, Method: Composition-based stats. Identities = 70/333 (21%), Positives = 120/333 (36%), Gaps = 79/333 (23%) Query: 10 TVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAY 69 TVE+G+ + R + G V A D + + A+K+L + A Sbjct: 21 TVELGELRLRVR------RVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRA--II 72 Query: 70 REFKLMKLVN-HKNIIGLLNA--FTPQRNLEEFQDVYLVMELMDANLCQVIQM-----DL 121 +E MK ++ H NI+ +A + + + L+ EL L + ++ L Sbjct: 73 QEVCFMKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGPL 132 Query: 122 DHDRMSYLLYQMLCGIKHLHSAG--IIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFM 179 D + + YQ ++H+H IIHRDLK N+++ T+K+ DFG A T Sbjct: 133 SCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPD 192 Query: 180 MT-------------PYVVTRYYRAPEVI---LGMGYTENVDIWSVGCIMGEMIRGGVLF 223 + T YR PE+I E DIW++GCI+ + F Sbjct: 193 YSWSAQRRALVEEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPF 252 Query: 224 PGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNN 283 + +I+ + P Q Sbjct: 253 EDGAKL----RIVNGKYSIPPHDTQ----------------------------------- 273 Query: 284 QNSRRKASDARNLLSKMLVIDPEQRISVDEALK 316 + +L+ ML ++PE+R+S+ E + Sbjct: 274 ------YTVFHSLIRAMLQVNPEERLSIAEVVH 300 >6O8B-A nrPDB Length = 665 Score = 172 bits (437), Expect = 2e-43, Method: Composition-based stats. Identities = 59/256 (23%), Positives = 97/256 (37%), Gaps = 25/256 (9%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSR-PFQNVTHAKRAYREFKLMKLVNHKN 82 ++ +G GA V T AIK + F + REF+++K +NHKN Sbjct: 17 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHKN 74 Query: 83 IIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQ-----MDLDHDRMSYLLYQMLCG 136 I+ L + L+ME +L V++ L +L ++ G Sbjct: 75 IVKLFAI----EEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGG 130 Query: 137 IKHLHSAGIIHRDLKPSNIV--VKADCT--LKILDFGLARTAGTTFMMTPYVVTRYYRAP 192 + HL GI+HR++KP NI+ + D K+ DFG AR T Y P Sbjct: 131 MNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVELYGTEEYLHP 190 Query: 193 EVIL--------GMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSP 244 ++ Y VD+WS+G G + F + + +++ ++ T P Sbjct: 191 DMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKP 250 Query: 245 SFMQRLQPTVRNYVEN 260 S N + Sbjct: 251 SGAISGVQKAENGPID 266 >4X7Q-B nrPDB Length = 312 Score = 172 bits (436), Expect = 2e-43, Method: Composition-based stats. Identities = 65/316 (20%), Positives = 106/316 (33%), Gaps = 70/316 (22%) Query: 20 IHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSR----PFQNVTHAKRAYREFKLM 75 + Y +G G G V A + + VAIK + R + ++ + E L+ Sbjct: 29 FEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALL 88 Query: 76 ----KLVNHKNIIGLLNAFTPQRNLEEFQDVYLVME--LMDANLCQVI--QMDLDHDRMS 127 H +I LL+ F Q LV+E L +L I + L Sbjct: 89 WKVGAGGGHPGVIRLLDWFETQEGF------MLVLERPLPAQDLFDYITEKGPLGEGPSR 142 Query: 128 YLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-ADCTLKILDFGLARTAGTTFMMTPYVVT 186 Q++ I+H HS G++HRD+K NI++ K++DFG + T + T Sbjct: 143 CFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFG-SGALLHDEPYTDFDGT 201 Query: 187 RYYRAPEVILGMGY-TENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPS 245 R Y PE I Y +WS+G ++ +M+ G + F Sbjct: 202 RVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFE--------------------- 240 Query: 246 FMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDP 305 D + D L+ + L P Sbjct: 241 ----------------------------RDQEILEAELHFPAHVSPDCCALIRRCLAPKP 272 Query: 306 EQRISVDEALKHEYIN 321 R S++E L ++ Sbjct: 273 SSRPSLEEILLDPWMQ 288 >6NT9-A nrPDB Length = 742 Score = 172 bits (436), Expect = 2e-43, Method: Composition-based stats. Identities = 59/256 (23%), Positives = 97/256 (37%), Gaps = 25/256 (9%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSR-PFQNVTHAKRAYREFKLMKLVNHKN 82 ++ +G GA V T AIK + F + REF+++K +NHKN Sbjct: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHKN 66 Query: 83 IIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQ-----MDLDHDRMSYLLYQMLCG 136 I+ L + L+ME +L V++ L +L ++ G Sbjct: 67 IVKLFAI----EEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGG 122 Query: 137 IKHLHSAGIIHRDLKPSNIV--VKADCT--LKILDFGLARTAGTTFMMTPYVVTRYYRAP 192 + HL GI+HR++KP NI+ + D K+ DFG AR T Y P Sbjct: 123 MNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHP 182 Query: 193 EVIL--------GMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSP 244 ++ Y VD+WS+G G + F + + +++ ++ T P Sbjct: 183 DMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKP 242 Query: 245 SFMQRLQPTVRNYVEN 260 S N + Sbjct: 243 SGAISGVQKAENGPID 258 >3ZZW-A nrPDB Length = 289 Score = 172 bits (436), Expect = 2e-43, Method: Composition-based stats. Identities = 56/266 (21%), Positives = 103/266 (38%), Gaps = 28/266 (10%) Query: 27 LRPIGSGAQGIVCAAYD-----TITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHK 81 + +G G V + Q VAIK L + + E L + H Sbjct: 14 MEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPL-REEFRHEAMLRARLQHP 72 Query: 82 NIIGLLNAFTPQRNLEEFQDVY--------LVM-----ELMDANLCQVIQMDLDHDRMSY 128 N++ LL T + L LVM ++ + + ++ L+ + Sbjct: 73 NVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVH 132 Query: 129 LLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTA---GTTFMMTPYVV 185 L+ Q+ G+++L S ++H+DL N++V +KI D GL R ++ ++ Sbjct: 133 LVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSLL 192 Query: 186 TRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGV-LFPGTDHIDQWNKIIEQLGTPSP 244 + APE I+ ++ + DIWS G ++ E+ G+ + G + D I + P P Sbjct: 193 PIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCP 252 Query: 245 S-----FMQRLQPTVRNYVENRPRYT 265 + + RPR+ Sbjct: 253 DDCPAWVYALMIECWNEFPSRRPRFK 278 >5WNO-A nrPDB Length = 330 Score = 172 bits (435), Expect = 3e-43, Method: Composition-based stats. Identities = 60/282 (21%), Positives = 110/282 (39%), Gaps = 20/282 (7%) Query: 28 RPIGSGAQGIVCAA-----YDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKN 82 + +G+GA G V A + VAIK + + E M + H N Sbjct: 28 KKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQT---DQSQTDEMLEEATNMFRLRHDN 84 Query: 83 IIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGIKHLHS 142 ++ ++ L+ + L N ++ + +L YQ+ G+++L Sbjct: 85 LLKIIGFCMHDDGLKIVTIYRPLGNL--QNFLKLHKENLGAREQVLYCYQIASGMQYLEK 142 Query: 143 AGIIHRDLKPSNIVVKADCTLKILDFGLARTAG---TTFMMTPYVVTRYYRAPEVILGMG 199 ++HRDL N++VK ++I DFGL++ + + V + A E+ Sbjct: 143 QRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIEIFSKHC 202 Query: 200 YTENVDIWSVGCIMGEMIR-GGVLFPG--TDHIDQWNKIIEQLGTPSPSFMQRLQPTVRN 256 YT D+W+ G E+I G + G TD I + K +L P Q +R Sbjct: 203 YTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQPPNCSQDLYQELLRC 262 Query: 257 YVENRPRYTGYS--FDRLFPDGLFPNDNNQNSRRKASDARNL 296 ++ + G+ ++R P +NS + + +L Sbjct: 263 WMADPKSRPGFEILYERFKEFCKVPQLFLENSNKISES--DL 302 >5TOS-A nrPDB Length = 395 Score = 171 bits (434), Expect = 4e-43, Method: Composition-based stats. Identities = 64/309 (20%), Positives = 114/309 (36%), Gaps = 54/309 (17%) Query: 29 PIGSGAQGIVCAAY---------DTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVN 79 IG G G V + T +A+KKL++ + + E + ++ Sbjct: 72 VIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQ--EGFQGHREWLTEINYLGQLS 129 Query: 80 HKNIIGLLNAFTPQRNLEEFQDVYLVMELM-DANLCQVIQ------MDLDHDRMSYLLYQ 132 H N++ L+ + LV E M +L + L + Sbjct: 130 HPNLVKLIGYCLEDEHR------LLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALD 183 Query: 133 MLCGIKHLHS--AGIIHRDLKPSNIVVKADCTLKILDFGLAR---TAGTTFMMTPYVVTR 187 G+ LHS +I+RD+K SNI++ AD K+ DFGLAR +++ T + T Sbjct: 184 AAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTY 243 Query: 188 YYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFM 247 Y APE + D++S G ++ E++ G L P+ Sbjct: 244 GYAAPEYMSSGHLNARSDVYSFGVLLLEILSGK----------------RALDHNRPAKE 287 Query: 248 QRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQ 307 + L R Y+ ++ + +RL L S + L +P+ Sbjct: 288 ENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAV---------QCLSFEPKS 338 Query: 308 RISVDEALK 316 R ++D+ ++ Sbjct: 339 RPTMDQVVR 347 >5C26-A nrPDB Length = 299 Score = 170 bits (430), Expect = 1e-42, Method: Composition-based stats. Identities = 63/275 (22%), Positives = 110/275 (40%), Gaps = 24/275 (8%) Query: 12 EVGDTNFTIHSRYINL--RPIGSGAQGIVCAAYDT--ITQQNVAIKKLSRPFQNVTHAKR 67 E+ + + + L + +GSG G V Y + VA+K L + Sbjct: 15 EIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDE 74 Query: 68 AYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQ--MDLDHD 124 E +M+ +++ I+ ++ E + LVME+ + L + +Q + Sbjct: 75 LLAEANVMQQLDNPYIVRMIGIC-------EAESWMLVMEMAELGPLNKYLQQNRHVKDK 127 Query: 125 RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMM---- 180 + L++Q+ G+K+L + +HRDL N+++ KI DFGL++ Sbjct: 128 NIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQ 187 Query: 181 TPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQ--WNKIIE 237 T + APE I ++ D+WS G +M E G + G + + E Sbjct: 188 THGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGE 247 Query: 238 QLGTP--SPSFMQRLQPTVRNY-VENRPRYTGYSF 269 ++G P P M L Y VENRP + Sbjct: 248 RMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVEL 282 >4IDT-A nrPDB Length = 356 Score = 169 bits (427), Expect = 2e-42, Method: Composition-based stats. Identities = 54/204 (26%), Positives = 82/204 (40%), Gaps = 23/204 (11%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNA 89 +G G+ G V D T A+KK+ E + I+ L A Sbjct: 82 LGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRAE-------ELMACAGLTSPRIVPLYGA 134 Query: 90 FTPQRNLEEFQDVYLVMELMDANLCQVI---QMDLDHDRMSYLLYQMLCGIKHLHSAGII 146 + F MEL++ + Q L DR Y L Q L G+++LHS I+ Sbjct: 135 VREGPWVNIF------MELLEGGSLGQLVKEQGCLPEDRALYYLGQALEGLEYLHSRRIL 188 Query: 147 HRDLKPSNIVVKADC-TLKILDFGLARTAGTTFMMTPYV------VTRYYRAPEVILGMG 199 H D+K N+++ +D + DFG A + + T + APEV+LG Sbjct: 189 HGDVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKDLLTGDYIPGTETHMAPEVVLGRS 248 Query: 200 YTENVDIWSVGCIMGEMIRGGVLF 223 VD+WS C+M M+ G + Sbjct: 249 CDAKVDVWSSCCMMLHMLNGCHPW 272 >5WNL-A nrPDB Length = 342 Score = 168 bits (426), Expect = 3e-42, Method: Composition-based stats. Identities = 65/353 (18%), Positives = 116/353 (32%), Gaps = 60/353 (16%) Query: 22 SRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHK 81 + +GSG G V + +AIK + E K M++ + Sbjct: 20 GEFAGWEKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRERMELLEEAKKMEMAKFR 79 Query: 82 NIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVI--QMDLDHDRMSYLLYQMLCGIKH 139 I+ + V LVME M+ + + L D ++++ G+ Sbjct: 80 YILPVYGICQE--------PVGLVMEYMETGSLEKLLASEPLPWDLRFRIVHETAVGMNF 131 Query: 140 LH--SAGIIHRDLKPSNIVVKADCTLKILDFGLARTAG----TTFMMTPYVVTRYYRAPE 193 LH S ++H +LKP+NI++ A +KI DFGLA+ G M T Y PE Sbjct: 132 LHCMSPPLLHLNLKPANILLDAHYHVKISDFGLAKCNGMSHSHDLSMDGLFGTIAYLPPE 191 Query: 194 VILGMG--YTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQ 251 I + D++S ++ ++ F D + + +++ + P + Sbjct: 192 RIREKSRLFDTKHDVYSFAIVIWGVLTQKKPF--ADEKNILHIMMKVVKGHRPELPPICR 249 Query: 252 PTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISV 311 P RPR L+ + DP+ R + Sbjct: 250 P--------RPRACA-------------------------SLIGLMQRCWHADPQVRPTF 276 Query: 312 DEALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYEEVMDYEA 364 E + + P E D + + E + + K E + Sbjct: 277 QEI-------TSETEDLCEKPDEEVKDLAHEPGEKSSLESKSEARPESSRLKR 322 >3QD2-B nrPDB Length = 332 Score = 168 bits (426), Expect = 3e-42, Method: Composition-based stats. Identities = 66/299 (22%), Positives = 112/299 (37%), Gaps = 76/299 (25%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNI 83 + ++ +G G G+V A + + N AIK++ P + + ++ RE K + + H I Sbjct: 8 FEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELA-REKVMREVKALAKLEHPGI 66 Query: 84 IGLLNAF--TPQRNLEEFQD---------------------------------------- 101 + NA+ TP +E D Sbjct: 67 VRYFNAWLETPPEKWQEEMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFSTKNTVGQ 126 Query: 102 ---------VYLVMELM-DANLCQVIQMDLD-----HDRMSYLLYQMLCGIKHLHSAGII 146 +Y+ M+L NL + H ++ Q+ ++ LHS G++ Sbjct: 127 LQPSSPKVYLYIQMQLCRKENLKDWMNRRCSLEDREHGVCLHIFIQIAEAVEFLHSKGLM 186 Query: 147 HRDLKPSNIVVKADCTLKILDFGLARTAGTTFM-------------MTPYVVTRYYRAPE 193 HRDLKPSNI D +K+ DFGL T V T+ Y +PE Sbjct: 187 HRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQVGTKLYMSPE 246 Query: 194 VILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQP 252 I G Y+ VDI+S+G I+ E++ + + +++ I + P + P Sbjct: 247 QIHGNNYSHKVDIFSLGLILFELL-----YSFSTQMERVRIITDVRNLKFPLLFTQKYP 300 >4G3E-A nrPDB Length = 352 Score = 168 bits (425), Expect = 4e-42, Method: Composition-based stats. Identities = 56/204 (27%), Positives = 87/204 (42%), Gaps = 23/204 (11%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNA 89 +G G+ G V D T A+KK+ V E ++ I+ L A Sbjct: 82 VGRGSFGEVHRMKDKQTGFQCAVKKVRLEVFRVE-------ELVACAGLSSPRIVPLYGA 134 Query: 90 FTPQRNLEEFQDVYLVMELMDAN-LCQVIQM--DLDHDRMSYLLYQMLCGIKHLHSAGII 146 + F MEL++ L Q+I+ L DR Y L Q L G+++LH+ I+ Sbjct: 135 VREGPWVNIF------MELLEGGSLGQLIKQMGCLPEDRALYYLGQALEGLEYLHTRRIL 188 Query: 147 HRDLKPSNIVVKADC-TLKILDFGLARTAGTTFMMTPYV------VTRYYRAPEVILGMG 199 H D+K N+++ +D + DFG A + + T + APEV++G Sbjct: 189 HGDVKADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAPEVVMGKP 248 Query: 200 YTENVDIWSVGCIMGEMIRGGVLF 223 VDIWS C+M M+ G + Sbjct: 249 CDAKVDIWSSCCMMLHMLNGCHPW 272 >5LPZ-A nrPDB Length = 332 Score = 167 bits (423), Expect = 7e-42, Method: Composition-based stats. Identities = 54/215 (25%), Positives = 86/215 (40%), Gaps = 22/215 (10%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNA 89 IGSG G V A VAIKKL + E + + + H+N++ LL Sbjct: 25 IGSGGFGDVYKAILK-DGSAVAIKKLIHVSGQGD--REFMAEMETIGKIKHRNLVPLLGY 81 Query: 90 FTPQRNLEEFQDVYLVMELMD-ANLCQVIQ------MDLDHDRMSYLLYQMLCGIKHLH- 141 + + LV E M +L V+ + L+ + G+ LH Sbjct: 82 C------KVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHH 135 Query: 142 --SAGIIHRDLKPSNIVVKADCTLKILDFGLARTA---GTTFMMTPYVVTRYYRAPEVIL 196 S IIHRD+K SN+++ + ++ DFG+AR T ++ T Y PE Sbjct: 136 NCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYYQ 195 Query: 197 GMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQ 231 + D++S G ++ E++ G D D Sbjct: 196 SFRCSTKGDVYSYGVVLLELLTGKRPTDSPDFGDN 230 >5LPV-A nrPDB Length = 296 Score = 167 bits (422), Expect = 1e-41, Method: Composition-based stats. Identities = 54/215 (25%), Positives = 86/215 (40%), Gaps = 22/215 (10%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNA 89 IGSG G V A VAIKKL + E + + + H+N++ LL Sbjct: 25 IGSGGFGDVYKAILK-DGSAVAIKKLIHVSGQGD--REFMAEMETIGKIKHRNLVPLLGY 81 Query: 90 FTPQRNLEEFQDVYLVMELMD-ANLCQVIQ------MDLDHDRMSYLLYQMLCGIKHLH- 141 + + LV E M +L V+ + L+ + G+ LH Sbjct: 82 C------KVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHH 135 Query: 142 --SAGIIHRDLKPSNIVVKADCTLKILDFGLARTA---GTTFMMTPYVVTRYYRAPEVIL 196 S IIHRD+K SN+++ + ++ DFG+AR T ++ T Y PE Sbjct: 136 NCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYYQ 195 Query: 197 GMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQ 231 + D++S G ++ E++ G D D Sbjct: 196 SFRCSTKGDVYSYGVVLLELLTGKRPTDSPDFGDN 230 >2BUJ-A nrPDB Length = 317 Score = 166 bits (421), Expect = 1e-41, Method: Composition-based stats. Identities = 60/266 (22%), Positives = 107/266 (40%), Gaps = 27/266 (10%) Query: 21 HSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNH 80 + Y+ ++ +G G V A+K++ + A RE + +L NH Sbjct: 28 NKHYLFIQKLGEGGFSYVDLVEGLHDGHFYALKRIL--CHEQQDREEAQREADMHRLFNH 85 Query: 81 KNIIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQMD------LDHDRMSYLLYQM 133 NI+ L+ +R + + +L++ L I+ L D++ +LL + Sbjct: 86 PNILRLVAYCLRERGAK--HEAWLLLPFFKRGTLWNEIERLKDKGNFLTEDQILWLLLGI 143 Query: 134 LCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGL----------ARTAGTTFMMTPY 183 G++ +H+ G HRDLKP+NI++ + ++D G +R A T Sbjct: 144 CRGLEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSRQALTLQDWAAQ 203 Query: 184 VVTRYYRAPEVILGMGY---TENVDIWSVGCIMGEMIRGGVLFP--GTDHIDQWNKIIEQ 238 T YRAPE+ + E D+WS+GC++ M+ G + + Q Sbjct: 204 RCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPYDMVFQKGDSVALAVQNQ 263 Query: 239 LGTP-SPSFMQRLQPTVRNYVENRPR 263 L P SP L + + + P Sbjct: 264 LSIPQSPRHSSALWQLLNSMMTVDPH 289 >6HV0-A nrPDB Length = 416 Score = 166 bits (420), Expect = 1e-41, Method: Composition-based stats. Identities = 80/310 (25%), Positives = 122/310 (39%), Gaps = 71/310 (22%) Query: 29 PIGSGAQGI-VCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVN-HKNIIGL 86 +G GA+G V ++VA+K++ A RE +L++ + H N+I Sbjct: 15 VLGHGAEGTIVYRG--MFDNRDVAVKRIL-----PECFSFADREVQLLRESDEHPNVIRY 67 Query: 87 LNAFTPQRNLEEFQDVYLVMELMDANLCQVI-QMDLDHDRM--SYLLYQMLCGIKHLHSA 143 T + + Q Y+ +EL A L + + Q D H + LL Q G+ HLHS Sbjct: 68 F--CTEK----DRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITLLQQTTSGLAHLHSL 121 Query: 144 GIIHRDLKPSNIVV---KADCTLK--ILDFGLARTAGTT----FMMTPYVVTRYYRAPEV 194 I+HRDLKP NI++ A +K I DFGL + + T + APE+ Sbjct: 122 NIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEM 181 Query: 195 IL---GMGYTENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRL 250 + T VDI+S GC+ +I G F G Q N ++ Sbjct: 182 LSEDCKENPTYTVDIFSAGCVFYYVISEGSHPF-GKSLQRQANILL-------------- 226 Query: 251 QPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRIS 310 G D + + AR L+ KM+ +DP++R S Sbjct: 227 -------------------------GACSLDCLHPEKHEDVIARELIEKMIAMDPQKRPS 261 Query: 311 VDEALKHEYI 320 LKH + Sbjct: 262 AKHVLKHPFF 271 >4PL5-B nrPDB Length = 435 Score = 165 bits (419), Expect = 2e-41, Method: Composition-based stats. Identities = 81/310 (26%), Positives = 124/310 (40%), Gaps = 71/310 (22%) Query: 29 PIGSGAQGI-VCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVN-HKNIIGL 86 +G GA+G V ++VA+K++ A RE +L++ + H N+I Sbjct: 34 VLGHGAEGTIVYKG--MFDNRDVAVKRIL-----PECFSFADREVQLLRESDEHPNVIRY 86 Query: 87 LNAFTPQRNLEEFQDVYLVMELMDANLCQVI-QMDLDHDRM--SYLLYQMLCGIKHLHSA 143 T + + Q Y+ +EL A L + + Q D H + LL+Q G+ HLHS Sbjct: 87 F--CTEK----DRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITLLHQTTSGLAHLHSL 140 Query: 144 GIIHRDLKPSNIVV---KADCTLK--ILDFGLARTAGTT----FMMTPYVVTRYYRAPEV 194 I+HRDLKP NI++ A +K I DFGL + + T + APE+ Sbjct: 141 NIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEM 200 Query: 195 IL---GMGYTENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRL 250 + T VDI+S GC+ +I G F G Q N ++ Sbjct: 201 LSEDCKDNPTYTVDIFSAGCVFYYVISEGYHPF-GKSLQRQANILL-------------- 245 Query: 251 QPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRIS 310 G D + + + AR L+ KM+ +DP+QR S Sbjct: 246 -------------------------GACNLDCFHSDKHEDVIARELIEKMIAMDPQQRPS 280 Query: 311 VDEALKHEYI 320 LKH + Sbjct: 281 AKHVLKHPFF 290 >4F0G-A nrPDB Length = 287 Score = 165 bits (417), Expect = 3e-41, Method: Composition-based stats. Identities = 56/251 (22%), Positives = 102/251 (40%), Gaps = 30/251 (11%) Query: 28 RPIGSGAQGIVCAAYDTITQQNVAIKKL-----SRPFQNVTHAKRAYREFKLMKLVNHKN 82 + IG G G+V + VAIK L + + + RE +M +NH N Sbjct: 25 KQIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQREVFIMSNLNHPN 84 Query: 83 IIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQMD---LDHDRMSYLLYQMLCGIK 138 I+ L +VME + +L + + L+ + GI+ Sbjct: 85 IVKLYGLMHNPPR--------MVMEFVPCGDLYHRLLDKAHPIKWSVKLRLMLDIALGIE 136 Query: 139 HLHSAG--IIHRDLKPSNIVV---KADCTL--KILDFGLARTAGTTFMMTPYVVTRYYRA 191 ++ + I+HRDL+ NI + + + K+ DFGL++ + ++ + + A Sbjct: 137 YMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQ--SVHSVSGLLGNFQWMA 194 Query: 192 PEVI--LGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHID-QWNKIIEQLGTPSPSFMQ 248 PE I YTE D +S I+ ++ G F + ++ +I + G P+ + Sbjct: 195 PETIGAEEESYTEKADTYSFAMILYTILTGEGPFDEYSYGKIKFINMIREEGL-RPTIPE 253 Query: 249 RLQPTVRNYVE 259 P +RN +E Sbjct: 254 DCPPRLRNVIE 264 >2H34-A nrPDB Length = 309 Score = 165 bits (417), Expect = 3e-41, Method: Composition-based stats. Identities = 67/282 (23%), Positives = 117/282 (41%), Gaps = 14/282 (4%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQ-NVTHAKRAYREFKLMKLVNHKN 82 Y R +G G G V A DT+ ++ VA+K +S + R RE + + + Sbjct: 36 YRLRRLVGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPVFRTRMQREARTAGRLQEPH 95 Query: 83 IIGLLNAFTPQRNLEEFQDVYLVMELMDA-NLCQVIQMD--LDHDRMSYLLYQMLCGIKH 139 ++ + + E +Y+ M L++ +L +++ L R ++ Q+ + Sbjct: 96 VVPIHDF------GEIDGQLYVDMRLINGVDLAAMLRRQGPLAPPRAVAIVRQIGSALDA 149 Query: 140 LHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTF--MMTPYVVTRYYRAPEVILG 197 H+AG HRD+KP NI+V AD ++DFG+A + V T YY APE Sbjct: 150 AHAAGATHRDVKPENILVSADDFAYLVDFGIASATTDEKLTQLGNTVGTLYYMAPERFSE 209 Query: 198 MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNY 257 T DI+++ C++ E + G + G D + I Q P PS ++ P + Sbjct: 210 SHATYRADIYALTCVLYECLTGSPPYQG-DQLSVMGAHINQ-AIPRPSTVRPGIPVAFDA 267 Query: 258 VENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSK 299 V R + L + + A ++L + Sbjct: 268 VIARGMAKNPEDRYVTCGDLSAAAHAALATADQDRATDILRR 309 >5TE0-A nrPDB Length = 347 Score = 164 bits (415), Expect = 6e-41, Method: Composition-based stats. Identities = 63/346 (18%), Positives = 116/346 (33%), Gaps = 78/346 (22%) Query: 13 VGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREF 72 +G T+ + G IV T A+K++ N + RE Sbjct: 16 IGRQQVTVD------EVLAEGGFAIVFLVR-TSNGMKCALKRMF--VNNEHDLQVCKREI 66 Query: 73 KLMKLVN-HKNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN-----LCQVIQMDLDHDRM 126 ++M+ ++ HKNI+G +++ + + +V ++M+ + Q +Q + + Sbjct: 67 QIMRDLSGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEV 126 Query: 127 SYLLYQMLCGIKHLHSAG--IIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPY- 183 + + LH IIHRDLK NI++ + DFG A Sbjct: 127 LQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVN 186 Query: 184 --------VVTRYYRAPEVIL---GMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQW 232 T YRAPE++ G T DIW++GC++ ++ + F G + Sbjct: 187 AVEDEIKKYTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPF-GESQVAIC 245 Query: 233 NKIIEQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASD 292 + N ++ R + D Sbjct: 246 D---------------------------------------------GNFTIPDNSRYSQD 260 Query: 293 ARNLLSKMLVIDPEQRISVDEALKHEYINVWYDAEEVDAPAPEPYD 338 L+ ML DP++R + + Y + +E P + Sbjct: 261 MHCLIRYMLEPDPDKRPDIYQV---SYFSFKLLKKECPIPNVQNSP 303 >3HNG-A nrPDB Length = 360 Score = 164 bits (414), Expect = 9e-41, Method: Composition-based stats. Identities = 65/327 (19%), Positives = 112/327 (34%), Gaps = 82/327 (25%) Query: 21 HSRYINLRPIGSGAQGIVCAA-----YDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLM 75 R + +G GA G V A + T + VA+K L + + K E K++ Sbjct: 26 RERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKML-KEGATASEYKALMTELKIL 84 Query: 76 KLVNHK----N--------------IIGLLNAFTPQRNLEEFQDVY-------LVME--- 107 + H N I+ L+ +D++ L ME Sbjct: 85 THIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKRDLFFLNKDAALHMEPKK 144 Query: 108 -LMDANLCQ-------------------------------------VIQMDLDHDRMSYL 129 M+ L Q + + + + Sbjct: 145 EKMEPGLEQGKKPRLDSVTSSESFASSGFQEDKSLSDVEEEEDSDGFYKEPITMEDLISY 204 Query: 130 LYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTA---GTTFMMTPYVVT 186 +Q+ G++ L S IHRDL NI++ + +KI DFGLAR + Sbjct: 205 SFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRKGDTRLP 264 Query: 187 RYYRAPEVILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQW-NKIIEQLGTPSP 244 + APE I Y+ D+WS G ++ E+ GG +PG + + +++ E + +P Sbjct: 265 LKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGMRMRAP 324 Query: 245 SF-----MQRLQPTVRNYVENRPRYTG 266 + Q + + RPR+ Sbjct: 325 EYSTPEIYQIMLDCWHRDPKERPRFAE 351 >3Q4U-A nrPDB Length = 301 Score = 163 bits (412), Expect = 1e-40, Method: Composition-based stats. Identities = 70/317 (22%), Positives = 114/317 (35%), Gaps = 55/317 (17%) Query: 19 TIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMK-- 76 T+ L +G G G V +NVA+K S K +RE +L Sbjct: 5 TVARDITLLECVGKGRYGEVWRGSWQ--GENVAVKIFS-----SRDEKSWFRETELYNTV 57 Query: 77 LVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQ-MDLDHDRMSYLLYQML 134 ++ H+NI+G + + R+ ++L+ + +L +Q LD ++ + Sbjct: 58 MLRHENILGFIASDMTSRH--SSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIA 115 Query: 135 CGIKHLH--------SAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMM-----T 181 G+ HLH I HRDLK NI+VK + I D GLA + Sbjct: 116 SGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNN 175 Query: 182 PYVVTRYYRAPEVILGM-------GYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNK 234 P V T+ Y APEV+ Y + VDIW+ G ++ E+ R Sbjct: 176 PRVGTKRYMAPEVLDETIQVDCFDSY-KRVDIWAFGLVLWEVAR---------------- 218 Query: 235 IIEQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDAR 294 S ++ +P + V N P + N S + Sbjct: 219 -----RMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLA 273 Query: 295 NLLSKMLVIDPEQRISV 311 L+ + +P R++ Sbjct: 274 KLMKECWYQNPSARLTA 290 >2RIO-A nrPDB Length = 434 Score = 162 bits (411), Expect = 2e-40, Method: Composition-based stats. Identities = 74/329 (22%), Positives = 126/329 (38%), Gaps = 86/329 (26%) Query: 28 RPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVN-HKNIIGL 86 + +G G+ G V + + VA+K++ F ++ A E KL+ + H N+I Sbjct: 21 KILGYGSSGTVVF-QGSFQGRPVAVKRMLIDFCDI-----ALMEIKLLTESDDHPNVIRY 74 Query: 87 LNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMS---------YLLYQMLCGI 137 + T R L Y+ +EL + NL +++ D LL Q+ G+ Sbjct: 75 YCSETTDRFL------YIALELCNLNLQDLVESKNVSDENLKLQKEYNPISLLRQIASGV 128 Query: 138 KHLHSAGIIHRDLKPSNIVVK-------------ADCTLKILDFGLARTAGTTFM----- 179 HLHS IIHRDLKP NI+V + + I DFGL + + Sbjct: 129 AHLHSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFRTN 188 Query: 180 MTPYVVTRYYRAPEVIL-------GMGYTENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQ 231 + T +RAPE++ T ++DI+S+GC+ ++ G F D + Sbjct: 189 LNNPSGTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPF--GDKYSR 246 Query: 232 WNKIIEQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKAS 291 + II + + R + Sbjct: 247 ESNIIRGI------------------------------------FSLDEMKCLHDRSLIA 270 Query: 292 DARNLLSKMLVIDPEQRISVDEALKHEYI 320 +A +L+S+M+ DP +R + + L+H Sbjct: 271 EATDLISQMIDHDPLKRPTAMKVLRHPLF 299 >3MDY-A nrPDB Length = 337 Score = 160 bits (404), Expect = 1e-39, Method: Composition-based stats. Identities = 73/316 (23%), Positives = 125/316 (39%), Gaps = 53/316 (16%) Query: 19 TIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMK-- 76 TI + ++ IG G G V + VA+K T +RE ++ + Sbjct: 34 TIAKQIQMVKQIGKGRYGEVWMGKWR--GEKVAVKVFF-----TTEEASWFRETEIYQTV 86 Query: 77 LVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQ-MDLDHDRMSYLLYQML 134 L+ H+NI+G + A + + +YL+ + + +L ++ LD M L Y + Sbjct: 87 LMRHENILGFIAA--DIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSV 144 Query: 135 CGIKHLH--------SAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTF-----MMT 181 G+ HLH I HRDLK NI+VK + T I D GLA + Sbjct: 145 SGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPN 204 Query: 182 PYVVTRYYRAPEVI---LGMGYTEN---VDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKI 235 V T+ Y PEV+ L + ++ D++S G I+ E+ R V I Sbjct: 205 TRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCV----------SGGI 254 Query: 236 IEQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARN 295 +E+ P L P+ +Y + R FP+ ++ + + Sbjct: 255 VEEYQLP----YHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGK------- 303 Query: 296 LLSKMLVIDPEQRISV 311 L+++ +P R++ Sbjct: 304 LMTECWAHNPASRLTA 319 >6J5U-C nrPDB Length = 426 Score = 159 bits (403), Expect = 2e-39, Method: Composition-based stats. Identities = 53/210 (25%), Positives = 85/210 (40%), Gaps = 27/210 (12%) Query: 30 IGSGAQGIVCAAY---------DTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNH 80 +G G G V + + VA+K+L + K E + ++H Sbjct: 92 LGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQLK--PEGFQGHKEWLTEVNYLGQLSH 149 Query: 81 KNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN-----LCQVIQMDLDHDRMSYLLYQMLC 135 N++ L+ E ++ LV E M L + L + Sbjct: 150 PNLVLLVGYC------AEGENRLLVYEFMPKGSLENHLFRRGAQPLTWAIRMKVAVGAAK 203 Query: 136 GIKHLHSAG--IIHRDLKPSNIVVKADCTLKILDFGLAR---TAGTTFMMTPYVVTRYYR 190 G+ LH A +I+RD K +NI++ AD K+ DFGLA+ T T + T + T Y Sbjct: 204 GLTFLHEAKSQVIYRDFKAANILLDADFNAKLSDFGLAKAGPTGDNTHVSTKVIGTHGYA 263 Query: 191 APEVILGMGYTENVDIWSVGCIMGEMIRGG 220 APE + T D++S G ++ E+I G Sbjct: 264 APEYVATGRLTAKSDVYSFGVVLLELISGR 293 >4F9B-A nrPDB Length = 361 Score = 157 bits (397), Expect = 7e-39, Method: Composition-based stats. Identities = 72/348 (20%), Positives = 125/348 (35%), Gaps = 57/348 (16%) Query: 24 YINLRPIGSGAQGIVCAAYDTI---TQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNH 80 + IG G V A + ++ +A+K L +H R E + + + Sbjct: 23 FKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLI----PTSHPIRIAAELQCLTVAGG 78 Query: 81 -KNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGIKH 139 N++G+ F + V + M ++ I L + + + +K Sbjct: 79 QDNVMGVKYCFRKNDH------VVIAMPYLEHESFLDILNSLSFQEVREYMLNLFKALKR 132 Query: 140 LHSAGIIHRDLKPSNIVVKAD-CTLKILDFGLARTAGTT--------------------- 177 +H GI+HRD+KPSN + ++DFGLA+ T Sbjct: 133 IHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNK 192 Query: 178 --------FMMTPYVVTRYYRAPEVILGMG-YTENVDIWSVGCIMGEMIRGGVLFP-GTD 227 + P T +RAPEV+ T +D+WS G I ++ G F +D Sbjct: 193 CSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASD 252 Query: 228 HIDQWNKIIEQLGT-----------PSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDG 276 + +I+ G+ S + + + R R S +L D Sbjct: 253 DLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSSTPKLTSDI 312 Query: 277 LFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEYINVWY 324 N + +A +LL K+L ++P RI+ +EAL H + Sbjct: 313 QGHATNLEGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFFKDMS 360 >3LMG-A nrPDB Length = 344 Score = 157 bits (397), Expect = 8e-39, Method: Composition-based stats. Identities = 47/259 (18%), Positives = 99/259 (38%), Gaps = 23/259 (8%) Query: 26 NLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLM---KLVNHKN 82 L+ +GSG G V +++ I + ++ + + M ++H + Sbjct: 35 KLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAH 94 Query: 83 IIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQMD---LDHDRMSYLLYQMLCGIK 138 I+ LL + LV + + +L ++ L + Q+ G+ Sbjct: 95 IVRLLGLC-------PGSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMY 147 Query: 139 HLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFM---MTPYVVTRYYRAPEVI 195 +L G++HR+L N+++K+ +++ DFG+A + + A E I Sbjct: 148 YLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESI 207 Query: 196 LGMGYTENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQ--WNKIIEQLGTPSPSFMQRLQP 252 YT D+WS G + E++ G + G + + E+L P + Sbjct: 208 HFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMV 267 Query: 253 TVRNYVEN---RPRYTGYS 268 V+ ++ + RP + + Sbjct: 268 MVKCWMIDENIRPTFKELA 286 >2PMN-X nrPDB Length = 348 Score = 156 bits (395), Expect = 1e-38, Method: Composition-based stats. Identities = 63/343 (18%), Positives = 120/343 (34%), Gaps = 62/343 (18%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTH---------------AKRA 68 Y +R + G + + A+KK + Sbjct: 33 YRIIRTLNQGKFNKIILCE--KDNKFYALKKYEKSLLEKKRDFTKSNNDKISIKSKYDDF 90 Query: 69 YREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANL---CQVIQMDLDHDR 125 E +++ + ++ T + + + +VY++ E M+ + LD + Sbjct: 91 KNELQIITDIKNEY------CLTCEGIITNYDEVYIIYEYMENDSILKFDEYFFVLDKNY 144 Query: 126 MSYLLYQMLCGI--------KHLH-SAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGT 176 ++ Q++ I ++H I HRD+KPSNI++ + +K+ DFG + Sbjct: 145 TCFIPIQVIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMDKNGRVKLSDFGESEYMVD 204 Query: 177 TFMMTPYVVTRYYRAPEVILGM-GY-TENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNK 234 + T + PE Y VDIWS+G + M V F Sbjct: 205 -KKIKGSRGTYEFMPPEFFSNESSYNGAKVDIWSLGICLYVMFYNVVPF----------- 252 Query: 235 IIEQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDAR 294 S L N Y L+P L + ++ +++ Sbjct: 253 ----------SLKISLVELFNNIRTKNIEYPLDRNHFLYP--LTNKKSTCSNNFLSNEDI 300 Query: 295 NLLSKMLVIDPEQRISVDEALKHEYINVWYDAEEVDAPAPEPY 337 + L L +P +RI+ ++ALKHE++ + E++ + E Y Sbjct: 301 DFLKLFLRKNPAERITSEDALKHEWLADT-NIEDLREFSKELY 342 >3MY0-A nrPDB Length = 305 Score = 156 bits (395), Expect = 1e-38, Method: Composition-based stats. Identities = 64/316 (20%), Positives = 111/316 (35%), Gaps = 53/316 (16%) Query: 19 TIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMK-- 76 T+ + + +G G G V ++VA+K S + +RE ++ Sbjct: 5 TVARQVALVECVGKGRYGEVWRGLWH--GESVAVKIFS-----SRDEQSWFRETEIYNTV 57 Query: 77 LVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQMDLDHDR-MSYLLYQML 134 L+ H NI+G + + RN ++L+ + +L +Q L Sbjct: 58 LLRHDNILGFIASDMTSRN--SSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAA 115 Query: 135 CGIKHLH--------SAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMM-----T 181 CG+ HLH I HRD K N++VK++ I D GLA Sbjct: 116 CGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNN 175 Query: 182 PYVVTRYYRAPEVILGMGYTEN------VDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKI 235 P V T+ Y APEV+ T+ DIW+ G ++ E+ R I Sbjct: 176 PRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIAR--------------RTI 221 Query: 236 IEQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARN 295 + + ++ +P + V N P + N + S Sbjct: 222 VNGI-------VEDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQ 274 Query: 296 LLSKMLVIDPEQRISV 311 ++ + +P R++ Sbjct: 275 MMRECWYPNPSARLTA 290 >3UIM-A nrPDB Length = 326 Score = 156 bits (394), Expect = 1e-38, Method: Composition-based stats. Identities = 47/215 (21%), Positives = 85/215 (39%), Gaps = 20/215 (9%) Query: 21 HSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNH 80 + N +G G G V VA+K+L + E +++ + H Sbjct: 29 SDNFSNKNILGRGGFGKVYKGR-LADGTLVAVKRLKEERTQGGELQ-FQTEVEMISMAVH 86 Query: 81 KNIIGLLNAFTPQRNLEEFQDVYLVMELM-DANLCQVIQMD------LDHDRMSYLLYQM 133 +N++ L + LV M + ++ ++ LD + + Sbjct: 87 RNLLRLRGFCMTP------TERLLVYPYMANGSVASCLRERPESQPPLDWPKRQRIALGS 140 Query: 134 LCGIKHLHSA---GIIHRDLKPSNIVVKADCTLKILDFGLARTAG--TTFMMTPYVVTRY 188 G+ +LH IIHRD+K +NI++ + + DFGLA+ T + T T Sbjct: 141 ARGLAYLHDHCDPKIIHRDVKAANILLDEEFEAVVGDFGLAKLMDYKDTHVTTAVRGTIG 200 Query: 189 YRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLF 223 + APE + +E D++ G ++ E+I G F Sbjct: 201 HIAPEYLSTGKSSEKTDVFGYGVMLLELITGQRAF 235 >2QKW-B nrPDB Length = 321 Score = 155 bits (392), Expect = 3e-38, Method: Composition-based stats. Identities = 47/198 (23%), Positives = 84/198 (42%), Gaps = 17/198 (8%) Query: 30 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNA 89 IG G G V VA+K R ++ + E + + H +++ L+ Sbjct: 47 IGHGVFGKVYKGVLR-DGAKVALK--RRTPESSQGIEEFETEIETLSFCRHPHLVSLIGF 103 Query: 90 FTPQRNLEEFQDVYLVMELMDANLCQVIQ------MDLDHDRMSYLLYQMLCGIKHLHSA 143 + E +Y ME + NL + + M + ++ + G+ +LH+ Sbjct: 104 CDERN---EMILIYKYME--NGNLKRHLYGSDLPTMSMSWEQRLEICIGAARGLHYLHTR 158 Query: 144 GIIHRDLKPSNIVVKADCTLKILDFGLAR---TAGTTFMMTPYVVTRYYRAPEVILGMGY 200 IIHRD+K NI++ + KI DFG+++ T + T T Y PE + Sbjct: 159 AIIHRDVKSINILLDENFVPKITDFGISKKGTELDQTHLSTVVKGTLGYIDPEYFIKGRL 218 Query: 201 TENVDIWSVGCIMGEMIR 218 TE D++S G ++ E++ Sbjct: 219 TEKSDVYSFGVVLFEVLC 236 >5IKW-A nrPDB Length = 310 Score = 155 bits (391), Expect = 3e-38, Method: Composition-based stats. Identities = 55/232 (23%), Positives = 88/232 (37%), Gaps = 25/232 (10%) Query: 13 VGDTNFTIHSRYINLRP-IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYRE 71 VG F + + L + G V T A+K++ N+ RE Sbjct: 4 VGVRVFAVGRHQVTLEESLAEGGFSTVFLVR-THGGIRCALKRM--YVNNMPDLNVCKRE 60 Query: 72 FKLMKLVN-HKNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN-----LCQVIQMDLDHDR 125 +MK ++ HKNI+G L+ + +V ++ME A + + +Q Sbjct: 61 ITIMKELSGHKNIVGYLD-CAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPE 119 Query: 126 MSYLLYQMLCGIKHLHSAG--IIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPY 183 + + + LH IIHRDLK NI++ + DFG A Sbjct: 120 VLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGV 179 Query: 184 ---------VVTRYYRAPEVIL---GMGYTENVDIWSVGCIMGEMIRGGVLF 223 T YRAPE+I G T DIW++GC++ ++ + F Sbjct: 180 NVVEEEIKKYTTLSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPF 231 >1PY5-A nrPDB Length = 326 Score = 153 bits (386), Expect = 1e-37, Method: Composition-based stats. Identities = 58/265 (21%), Positives = 104/265 (39%), Gaps = 47/265 (17%) Query: 25 INLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMK--LVNHKN 82 + IG G G V + VA+K S + +RE ++ + ++ H+N Sbjct: 32 VLQESIGKGRFGEVWRGKWR--GEEVAVKIFS-----SREERSWFREAEIYQTVMLRHEN 84 Query: 83 IIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVI-QMDLDHDRMSYLLYQMLCGIKHL 140 I+G + A ++ + ++LV + + +L + + + + M L G+ HL Sbjct: 85 ILGFIAA--DNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHL 142 Query: 141 H--------SAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGT-----TFMMTPYVVTR 187 H I HRDLK NI+VK + T I D GLA + V T+ Sbjct: 143 HMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTK 202 Query: 188 YYRAPEVILGM------GYTENVDIWSVGCIMGEMIR----------GGVLFPGTDHIDQ 231 Y APEV+ + DI+++G + E+ R + + D Sbjct: 203 RYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDP 262 Query: 232 WNKIIEQLGTPSPSFMQRLQPTVRN 256 + + ++ Q+L+P + N Sbjct: 263 SVEEMRKVVCE-----QKLRPNIPN 282 >3SOC-A nrPDB Length = 322 Score = 152 bits (385), Expect = 2e-37, Method: Composition-based stats. Identities = 65/322 (20%), Positives = 126/322 (39%), Gaps = 35/322 (10%) Query: 11 VEVGDTNFTIHSRYINLRPIG-SGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAY 69 V++G N S + L + G G V A + + VA+K P Q+ + Y Sbjct: 12 VDLGTENLYFQSMPLQLLEVKARGRFGCVWKAQ--LLNEYVAVKIF--PIQDKQSWQNEY 67 Query: 70 REFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQMDL-DHDRMS 127 E + + H+NI+ + A +R D++L+ + +L ++ ++ + + Sbjct: 68 -EVYSLPGMKHENILQFIGA--EKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELC 124 Query: 128 YLLYQMLCGIKHLHS----------AGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTT 177 ++ M G+ +LH I HRD+K N+++K + T I DFGLA Sbjct: 125 HIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAG 184 Query: 178 FM---MTPYVVTRYYRAPEVILG-----MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHI 229 V TR Y APEV+ G +D++++G ++ E+ G Sbjct: 185 KSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDE 244 Query: 230 DQWNKIIEQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRK 289 E PS MQ + + R + ++ + + + ++ R Sbjct: 245 YMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARL 304 Query: 290 ASDAR-NLLSKMLVIDPEQRIS 310 ++ +++M QR++ Sbjct: 305 SAGCVGERITQM------QRLT 320 >4M66-A nrPDB Length = 325 Score = 152 bits (385), Expect = 2e-37, Method: Composition-based stats. Identities = 51/214 (23%), Positives = 97/214 (45%), Gaps = 23/214 (10%) Query: 21 HSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNH 80 L +G G G+V A+ +VA+K ++ +K+ E K M + + Sbjct: 19 REELKKLEFVGKGGFGVVFRAHHRTWNHDVAVKIVN--------SKKISWEVKAMVNLRN 70 Query: 81 KNIIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQMD--LDHDRMSYLLYQMLCGI 137 +N++ LL T + LV M+ +L ++Q + + LL +++ G+ Sbjct: 71 ENVLLLLGV-TEDLQWDFVSGQALVTRFMENGSLAGLLQPEAPRPWPLLCRLLQEVVLGM 129 Query: 138 KHLHSAG--IIHRDLKPSNIVVKADCTLKILDFGLAR-------TAGTTFMMTPYVVTRY 188 +LHS ++HRDLKPSNI++ + K+ DFGL+ +G+ T Sbjct: 130 CYLHSLDPPLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQSGSGSGSGSRDSGGTLA 189 Query: 189 YRAPEVIL--GMGYTENVDIWSVGCIMGEMIRGG 220 Y PE++ + ++ D++S G ++ ++ G Sbjct: 190 YLDPELLFKVNLKASKASDVYSFGILVWAVLAGR 223 >5XD6-A nrPDB Length = 305 Score = 152 bits (383), Expect = 3e-37, Method: Composition-based stats. Identities = 49/226 (21%), Positives = 85/226 (37%), Gaps = 28/226 (12%) Query: 15 DTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKL 74 D I Y + IG G+ G V + + AIKKL Q + + + Sbjct: 15 DELRDITDNYGSKSLIGEGSYGRVFYGILK-SGKAAAIKKLDSSKQPD---QEFLAQVSM 70 Query: 75 MKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELM-DANLCQVIQMD-----------LD 122 + + +N++ LL L E + +L ++ L Sbjct: 71 VSRLRQENVVALLGYCVDGPLR------VLAYEYAPNGSLHDILHGRKGVKGAQPGPVLS 124 Query: 123 HDRMSYLLYQMLCGIKHLHSA---GIIHRDLKPSNIVVKADCTLKILDFGLARTAGT--- 176 + + G+++LH +IHRD+K SN+++ D KI DF L+ A Sbjct: 125 WHQRVKIAVGAARGLEYLHEKANPHVIHRDIKSSNVLLFDDDVAKIADFDLSNQAPDMAA 184 Query: 177 TFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVL 222 T + T Y APE + + D++S G ++ E++ G Sbjct: 185 RLHSTRVLGTFGYHAPEYAMTGTLSTKSDVYSFGVVLLELLTGRKP 230 >3G2F-A nrPDB Length = 336 Score = 148 bits (375), Expect = 3e-36, Method: Composition-based stats. Identities = 70/322 (21%), Positives = 115/322 (35%), Gaps = 58/322 (18%) Query: 22 SRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMK--LVN 79 L IG G G V ++ ++ VA+K S + + E + + L+ Sbjct: 13 DNLKLLELIGRGRYGAVYKG--SLDERPVAVKVFSFA-----NRQNFINEKNIYRVPLME 65 Query: 80 HKNIIGLLNAFTPQRNLEEFQDVYLVMELM-DANLCQVIQMDL-DHDRMSYLLYQMLCGI 137 H NI + + + + LVME + +LC+ + + D L + + G+ Sbjct: 66 HDNIARFI-VGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGL 124 Query: 138 KHLH---------SAGIIHRDLKPSNIVVKADCTLKILDFGLA---------RTAGTTFM 179 +LH I HRDL N++VK D T I DFGL+ R Sbjct: 125 AYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPGEEDNA 184 Query: 180 MTPYVVTRYYRAPEVILG-------MGYTENVDIWSVGCIMGEMIRGGV-LFPGTDHID- 230 V T Y APEV+ G + VD++++G I E+ LFPG + Sbjct: 185 AISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVPEY 244 Query: 231 QWNKIIEQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKA 290 Q E P+ MQ L + RP++ + + + Sbjct: 245 QMAFQTEVGNHPTFEDMQVLVSREK----QRPKFP---------------EAWKENSLAV 285 Query: 291 SDARNLLSKMLVIDPEQRISVD 312 + + D E R++ Sbjct: 286 RSLKETIEDCWDQDAEARLTAQ 307 >5AR8-A nrPDB Length = 326 Score = 147 bits (372), Expect = 5e-36, Method: Composition-based stats. Identities = 62/312 (19%), Positives = 119/312 (38%), Gaps = 49/312 (15%) Query: 26 NLRPIGSGAQGIVCAAYDTITQQNVAIKKL-SRPFQNVTHAKRAYREFKLMKLVNHKNII 84 +LR + GA G V +A + VA+K L + K RE +++ I+ Sbjct: 36 DLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYIL 95 Query: 85 GLLNAFTPQRNLEEFQDVYLVMELM-DANLCQVIQMDLDHDRMSY-----LLYQMLCGIK 138 +L E + + +V E M + +L +++ ++ +++ +L+++ G+ Sbjct: 96 PILGIC------NEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVN 149 Query: 139 HLHSAG--IIHRDLKPSNIVVKADCTLKILDFGLAR------TAGTTFMMTPYVVTRYYR 190 +LH+ ++H DLK NI++ + +KI DFGL++ + + P T Y Sbjct: 150 YLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYM 209 Query: 191 APEVI---LGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFM 247 PE + DI+S I E++ F + Q + Q Sbjct: 210 PPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQ--------- 260 Query: 248 QRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDAR-NLLSKMLVIDPE 306 +RP S P ++ + D R + L ++ ++P Sbjct: 261 -----------GHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPV 309 Query: 307 QR----ISVDEA 314 R I+ EA Sbjct: 310 LRTFEEITFLEA 321 >3SV0-A nrPDB Length = 483 Score = 147 bits (372), Expect = 6e-36, Method: Composition-based stats. Identities = 56/255 (21%), Positives = 104/255 (40%), Gaps = 34/255 (13%) Query: 20 IHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVN 79 + +++ R IGSG+ G + + T + VAIK + ++ + E K+ +++ Sbjct: 5 VGNKFRLGRKIGSGSFGEIYLGTNIQTNEEVAIKLENVKTKHP----QLLYESKIYRILQ 60 Query: 80 H----KNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQ---MDLDHDRMSYLLYQ 132 N + E LVM+L+ +L + L + L Q Sbjct: 61 GGTGIPN-VRWFGV--------EGDYNVLVMDLLGPSLEDLFNFCSRKLSLKTVLMLADQ 111 Query: 133 MLCGIKHLHSAGIIHRDLKPSNIVV---KADCTLKILDFGLARTAGTTFMM--------T 181 M+ ++ +HS +HRD+KP N ++ + + I+DFGLA+ T Sbjct: 112 MINRVEFVHSKSFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDTSTHQHIPYRENK 171 Query: 182 PYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGT---DHIDQWNKIIEQ 238 T Y + LG+ + D+ S+G ++ +RG + + G ++ KI E+ Sbjct: 172 NLTGTARYASVNTHLGIEQSRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKYEKISEK 231 Query: 239 LGTPSPSFMQRLQPT 253 S + R PT Sbjct: 232 KVATSIEALCRGYPT 246 >4TN6-A nrPDB Length = 318 Score = 145 bits (366), Expect = 3e-35, Method: Composition-based stats. Identities = 59/253 (23%), Positives = 105/253 (41%), Gaps = 26/253 (10%) Query: 18 FTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKL 77 + +RY R IGSG+ G + D + VAIK ++ + + E K+ K+ Sbjct: 3 LRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHP----QLHIESKIYKM 58 Query: 78 VNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQ---MDLDHDRMSYLLYQML 134 + G + T + E +VMEL+ +L + + L QM+ Sbjct: 59 MQ-----GGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMI 113 Query: 135 CGIKHLHSAGIIHRDLKPSNIVV---KADCTLKILDFGLARTAGT--TFMMTPY------ 183 I+++HS IHRD+KP N ++ K + I+DFGLA+ T PY Sbjct: 114 SRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNL 173 Query: 184 VVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPG---TDHIDQWNKIIEQLG 240 T Y + LG+ + D+ S+G ++ G + + G ++ +I E+ Sbjct: 174 TGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKM 233 Query: 241 TPSPSFMQRLQPT 253 + + + P+ Sbjct: 234 STPIEVLCKGYPS 246 >5FQD-C nrPDB Length = 341 Score = 143 bits (361), Expect = 1e-34, Method: Composition-based stats. Identities = 56/257 (21%), Positives = 101/257 (39%), Gaps = 26/257 (10%) Query: 14 GDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFK 73 F + +Y +R IGSG+ G + A + + VA+K Q H + Y E K Sbjct: 11 SKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVK---LESQKARHPQLLY-ESK 66 Query: 74 LMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQ---MDLDHDRMSYLL 130 L K++ G + + +E LVM+L+ +L + + L Sbjct: 67 LYKILQ-----GGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLA 121 Query: 131 YQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLK---ILDFGLARTAGTTFMM------- 180 QM+ I+++H+ IHRD+KP N ++ ++DFGLA+ Sbjct: 122 DQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYRE 181 Query: 181 -TPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPG---TDHIDQWNKII 236 T Y + LG+ + D+ S+G ++ R + + G ++ KI Sbjct: 182 DKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKIS 241 Query: 237 EQLGTPSPSFMQRLQPT 253 E+ + + + P Sbjct: 242 EKKMSTPVEVLCKGFPA 258 >4LQP-A nrPDB Length = 508 Score = 142 bits (357), Expect = 3e-34, Method: Composition-based stats. Identities = 36/166 (21%), Positives = 66/166 (39%), Gaps = 10/166 (6%) Query: 22 SRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQ-NVTHAKRAYREFKLMKLVNH 80 + ++ IG GA G V T + A+K L + E ++ + Sbjct: 102 EDFHTVKVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKDQLAHVKAERDVLAGSDS 161 Query: 81 KNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMD---LDHDRMSYLLYQMLCGI 137 ++ L +F + Q +YL+ME + + + D + + + + I Sbjct: 162 PWVVSLYYSFQ------DAQYLYLIMEFLPGGDLMTMLIRWQLFTEDVTRFYMAECILAI 215 Query: 138 KHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPY 183 + +H G IHR +KP NI++ +K+ DFGL+ T Y Sbjct: 216 ETIHKLGFIHRAIKPDNILIDIRGHIKLSDFGLSTGFHKTHDSNYY 261 Score = 94.3 bits (233), Expect = 8e-20, Method: Composition-based stats. Identities = 40/198 (20%), Positives = 65/198 (32%), Gaps = 46/198 (23%) Query: 181 TPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLG 240 V T Y APE+ L GY + D WS+G IM E + G F + + KI+ Sbjct: 321 YSTVGTPDYIAPEIFLYQGYGQECDWWSLGAIMYECLIGWPPFCSETPQETYRKIMN--- 377 Query: 241 TPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKM 300 + FPD + + +A +L+ ++ Sbjct: 378 --------------------------FEQTLQFPDDI----------HISYEAEDLIRRL 401 Query: 301 LVIDPEQRI----SVDEALKHEYIN--VWYDAEEVDAPAPEPYDHSVDEREHTVEQWKEL 354 L +QR+ DE H + W +V+AP D R ++ + + Sbjct: 402 LT-HADQRLGRHGGADEIKSHPFFRGVDWNTIRQVEAPYIPKLSSITDTRFFPTDELENV 460 Query: 355 IYEEVMDYEAHNTNNRTR 372 M A T+ Sbjct: 461 PDSPAMAQAAKQREQMTK 478 >4BTK-A nrPDB Length = 337 Score = 142 bits (357), Expect = 3e-34, Method: Composition-based stats. Identities = 57/255 (22%), Positives = 103/255 (40%), Gaps = 28/255 (10%) Query: 2 TTAQHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQN 61 T ++ N+ + R+ L+ IG G G + A D +T++NVA+K ++ Sbjct: 36 TNMSGGGEQADILPANYVVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKV-----ES 90 Query: 62 VTHAKRAYR-EFKLMKLVNHK-NIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQM 119 K+ + E ++K + K ++ + ++ Y+VM+L NL + + Sbjct: 91 AQQPKQVLKMEVAVLKKLQGKDHVCRFIGCGRNEKFN------YVVMQLQGRNLADLRRS 144 Query: 120 D----LDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNI----VVKADCTLKILDFGLA 171 L Q+L I+ +HS G +HRD+KPSN + +LDFGLA Sbjct: 145 QPRGTFTLSTTLRLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLA 204 Query: 172 RTAGTT-------FMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFP 224 R T + + T Y + + D+WS+ ++ E G + + Sbjct: 205 RQYTNTTGDVRPPRNVAGFRGTVRYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWR 264 Query: 225 GTDHIDQWNKIIEQL 239 +Q I E+ Sbjct: 265 KIKDKEQVGMIKEKY 279 >4NFN-A nrPDB Length = 309 Score = 140 bits (353), Expect = 8e-34, Method: Composition-based stats. Identities = 64/315 (20%), Positives = 117/315 (37%), Gaps = 36/315 (11%) Query: 5 QHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTH 64 ++ N+ + R+ L+ IG G G + A D +T++NVA+K ++ Sbjct: 4 SGGGEQADILPANYVVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKV-----ESAQQ 58 Query: 65 AKRAYR-EFKLMKLVNHK-NIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMD-- 120 K+ + E ++K + K ++ + ++ Y+VM+L NL + + Sbjct: 59 PKQVLKMEVAVLKKLQGKDHVCRFIGCGRNEKFN------YVVMQLQGRNLADLRRSQPR 112 Query: 121 --LDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNI----VVKADCTLKILDFGLARTA 174 L Q+L I+ +HS G +HRD+KPSN + +LDFGLAR Sbjct: 113 GTFTLSTTLRLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQY 172 Query: 175 GTT-------FMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTD 227 T + + T Y + + D+WS+ ++ E G + + Sbjct: 173 TNTTGDVRPPRNVAGFRGTVRYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIK 232 Query: 228 HIDQWNKIIEQ------LGTPSPSFMQRLQPTVRNYVENRPRYTGYS--FDRLFPDGLFP 279 +Q I E+ L F L +P Y F+ + Sbjct: 233 DKEQVGMIKEKYEHRMLLKHMPSEFHLFLDHIASLDYFTKPDYQLIMSVFENSMKERGIA 292 Query: 280 NDNNQNSRRKASDAR 294 + + + +DA Sbjct: 293 ENEAFDWEKAGTDAL 307 >5E8V-A nrPDB Length = 316 Score = 140 bits (353), Expect = 9e-34, Method: Composition-based stats. Identities = 55/231 (23%), Positives = 89/231 (38%), Gaps = 43/231 (18%) Query: 30 IGSGAQGIVCAAYDTITQ----QNVAIKKLS-RPFQNVTHAKRAYREFKLMKLVNHKNII 84 +G G V A + VA+K + + K + + + H+NI+ Sbjct: 17 VGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDI----NLKHENIL 72 Query: 85 GLLNAFTPQRNLEEFQDVYLVMEL-MDANLCQVI-QMDLDHDRMSYLLYQMLCGIKHLHS 142 L A +R E + +L+ NL + + + + + + L + GI HLHS Sbjct: 73 QFLTA--EERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHS 130 Query: 143 ---------AGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTP-----YVVTRY 188 I+HRDLK SNI+VK D T + DFGL+ T + V T Sbjct: 131 DHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTAR 190 Query: 189 YRAPEV------ILGMGYTENVDIWSVGCIMGEMIR----------GGVLF 223 Y APEV + + + D++S+ ++ EM F Sbjct: 191 YMAPEVLASAMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPF 241 >3VHK-A nrPDB Length = 368 Score = 137 bits (346), Expect = 5e-33, Method: Composition-based stats. Identities = 39/162 (24%), Positives = 69/162 (42%), Gaps = 10/162 (6%) Query: 115 QVIQMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTA 174 + + L + + +Q+ G++ L S IHRDL NI++ +KI DFGLAR Sbjct: 191 DLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDI 250 Query: 175 ---GTTFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGTDHID 230 + + APE I YT D+WS G ++ E+ G +PG + Sbjct: 251 YKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDE 310 Query: 231 QWNKIIE---QLGTP---SPSFMQRLQPTVRNYVENRPRYTG 266 ++ + ++ ++ P +P Q + RP ++ Sbjct: 311 EFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSE 352 Score = 71.2 bits (173), Expect = 7e-13, Method: Composition-based stats. Identities = 26/110 (23%), Positives = 44/110 (40%), Gaps = 13/110 (11%) Query: 21 HSRYINLRPIGSGAQGIVCAA----YDT-ITQQNVAIKKLSRPFQNVTHAKRAYREFKLM 75 R +P+G GA G V A D T + VA+K L + H E K++ Sbjct: 28 RDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHR-ALMSELKIL 86 Query: 76 -KLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQMDLDH 123 + +H N++ LL A T + +++E NL ++ + Sbjct: 87 IHIGHHLNVVNLLGACTKPG-----GPLMVIVEFCKFGNLSTYLRSKRNE 131 >5VC6-A nrPDB Length = 289 Score = 137 bits (345), Expect = 8e-33, Method: Composition-based stats. Identities = 64/326 (19%), Positives = 108/326 (33%), Gaps = 76/326 (23%) Query: 19 TIHSRYIN----LRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKL 74 ++ SRY L IGSG G V + AIK+ +P + A RE Sbjct: 4 SMKSRYTTEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYA 63 Query: 75 MKLV-NHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQV-IQMDLDHDRMSYLLYQ 132 ++ H +++ +A+ ++ + L DA I + LL Q Sbjct: 64 HAVLGQHSHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQ 123 Query: 133 MLCGIKHLHSAGIIHRDLKPSNIVVKADCTL-------------------KILDFGLART 173 + G++++HS ++H D+KPSNI + KI D G Sbjct: 124 VGRGLRYIHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTR 183 Query: 174 AGTTFMMTPYVVTRYYRAPEVILGMGYTE--NVDIWSVGCIMGEMIRGGVLFPGTDHIDQ 231 + + + A EV+ YT DI+++ + G P + DQ Sbjct: 184 ISSPQVEE---GDSRFLANEVLQ-ENYTHLPKADIFALALTV-VCAAGAEPLP--RNGDQ 236 Query: 232 WNKIIEQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKAS 291 W++I + P + + Sbjct: 237 WHEIRQGRLPRIPQVL------------------------------------------SQ 254 Query: 292 DARNLLSKMLVIDPEQRISVDEALKH 317 + LL M+ DPE+R S +KH Sbjct: 255 EFTELLKVMIHPDPERRPSAMALVKH 280 >2Y4I-B nrPDB Length = 319 Score = 137 bits (345), Expect = 9e-33, Method: Composition-based stats. Identities = 51/291 (17%), Positives = 106/291 (36%), Gaps = 35/291 (12%) Query: 22 SRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHK 81 + IG G G V VAI+ + N K RE + H+ Sbjct: 33 EQLEIGELIGKGRFGQVYHGRWHG---EVAIRLIDIERDNEDQLKAFKREVMAYRQTRHE 89 Query: 82 NIIGLLNAFTPQRNLEEFQDVYLVMELMDA----NLCQVIQMDLDHDRMSYLLYQMLCGI 137 N++ + A +L ++ L ++ + ++ LD ++ + +++ G+ Sbjct: 90 NVVLFMGACMSPPHLA------IITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGM 143 Query: 138 KHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAG------TTFMMTPYVVTRYYRA 191 +LH+ GI+H+DLK N+ + + I DFGL +G + + A Sbjct: 144 GYLHAKGILHKDLKSKNVFYD-NGKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCHLA 202 Query: 192 PEVILG---------MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTP 242 PE+I + ++++ D++++G I E+ F II Q+GT Sbjct: 203 PEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFK----TQPAEAIIWQMGTG 258 Query: 243 SPSFMQR--LQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKAS 291 + + + + + + + + +RR + Sbjct: 259 MKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLEKLPKRNRRLSH 309 >6BFN-A nrPDB Length = 342 Score = 136 bits (342), Expect = 2e-32, Method: Composition-based stats. Identities = 49/213 (23%), Positives = 77/213 (36%), Gaps = 29/213 (13%) Query: 29 PIGSGAQGIVCAAYDTITQQNVAIKKLSR--PFQNVTHAKRAYREFKLMKLVNHKNIIGL 86 IG G G V A T A+K+L + + E + + H NI+ Sbjct: 29 KIGEGGFGCVYRAVMRNT--VYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDF 86 Query: 87 LNAFTPQRNLEEFQDVYLVMELM-DANLCQVIQ------MDLDHDRMSYLLYQMLCGIKH 139 LV + + +L + L + +L I+ Sbjct: 87 AGYCAQNGF------YCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQF 140 Query: 140 LH--SAGIIHRDLKPSNIVVKADCTLKILDFGLA---RTAGTTFMMTPYV-------VTR 187 LH S +IH D+K SN+++ T K+ DFGLA R AG++ + V T Sbjct: 141 LHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTL 200 Query: 188 YYRAPEVILGMGYTENVDIWSVGCIMGEMIRGG 220 Y E I + D +S G ++ E + G Sbjct: 201 AYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQ 233 >2QLU-A nrPDB Length = 314 Score = 135 bits (340), Expect = 3e-32, Method: Composition-based stats. Identities = 48/208 (23%), Positives = 88/208 (42%), Gaps = 28/208 (13%) Query: 32 SGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNAFT 91 G G V A + VA+K + ++ RE + H+N++ + A Sbjct: 25 RGRFGCVWKAQ--LMNDFVAVKIFP---LQDKQSWQSEREIFSTPGMKHENLLQFIAAEK 79 Query: 92 PQRNLEEFQDVYLVMELMD-ANLCQVIQMDL-DHDRMSYLLYQMLCGIKHLHS------- 142 NLE +++L+ D +L ++ ++ + + ++ M G+ +LH Sbjct: 80 RGSNLEV--ELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPWCRG 137 Query: 143 ----AGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFM---MTPYVVTRYYRAPEVI 195 I HRD K N+++K+D T + DFGLA V TR Y APEV+ Sbjct: 138 EGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVGTRRYMAPEVL 197 Query: 196 LG-----MGYTENVDIWSVGCIMGEMIR 218 G +D++++G ++ E++ Sbjct: 198 EGAINFQRDAFLRIDMYAMGLVLWELVS 225 >4RT7-A nrPDB Length = 415 Score = 131 bits (329), Expect = 5e-31, Method: Composition-based stats. Identities = 38/158 (24%), Positives = 63/158 (39%), Gaps = 10/158 (6%) Query: 121 LDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMM 180 L + + YQ+ G++ L +HRDL N++V +KI DFGLAR + Sbjct: 240 LTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNY 299 Query: 181 ---TPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIR-GGVLFPGTDHIDQWNKII 236 + + APE + YT D+WS G ++ E+ G +PG + K+I Sbjct: 300 VVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLI 359 Query: 237 E------QLGTPSPSFMQRLQPTVRNYVENRPRYTGYS 268 + Q + +Q RP + + Sbjct: 360 QNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLT 397 Score = 75.8 bits (185), Expect = 3e-14, Method: Composition-based stats. Identities = 27/122 (22%), Positives = 49/122 (40%), Gaps = 15/122 (12%) Query: 15 DTNFTIH-SRYINLRPIGSGAQGIVCAAYD---TITQQ--NVAIKKLSRPFQNVTHAKRA 68 D + + +GSGA G V A + T VA+K L + + + + Sbjct: 57 DLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKML-KEKADSSEREAL 115 Query: 69 YREFKLMKLV-NHKNIIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQMDLDHDRM 126 E K+M + +H+NI+ LL A T +YL+ E +L ++ + Sbjct: 116 MSELKMMTQLGSHENIVNLLGACTLSG------PIYLIFEYCCYGDLLNYLRSKREKFHR 169 Query: 127 SY 128 ++ Sbjct: 170 TW 171 >5X18-A nrPDB Length = 295 Score = 130 bits (328), Expect = 6e-31, Method: Composition-based stats. Identities = 52/235 (22%), Positives = 96/235 (40%), Gaps = 30/235 (12%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNH-KN 82 Y + IG G+ G++ + I VAIK R T A + E+K K++N N Sbjct: 9 YKIGKKIGEGSFGVLFEGTNMINGVPVAIKFEPRK----TEAPQLRDEYKTYKILNGTPN 64 Query: 83 IIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQ---MDLDHDRMSYLLYQMLCGIKH 139 I + Q L LV++L+ +L + + + QM+ I+ Sbjct: 65 I--PYAYYFGQEGLHNI----LVIDLLGPSLEDLFDWCGRKFSVKTVVQVAVQMITLIED 118 Query: 140 LHSAGIIHRDLKPSNIVVKADCT-----LKILDFGLARTAGT--------TFMMTPYVVT 186 LH+ +I+RD+KP N ++ + ++DFG+A+ T Sbjct: 119 LHAHDLIYRDIKPDNFLIGRPGQPDANNIHLIDFGMAKQYRDPKTKQHIPYREKKSLSGT 178 Query: 187 RYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPG---TDHIDQWNKIIEQ 238 Y + LG + D+ ++G + +RG + + G ++ ++ KI E+ Sbjct: 179 ARYMSINTHLGREQSRRDDMEALGHVFFYFLRGHLPWQGLKAPNNKQKYEKIGEK 233 >5L2Q-C nrPDB Length = 320 Score = 130 bits (328), Expect = 8e-31, Method: Composition-based stats. Identities = 50/316 (15%), Positives = 108/316 (34%), Gaps = 79/316 (25%) Query: 39 CAAYDTITQQNVAIKKLSRPFQNVTHAKRAYR---------EFKLMKLVNHKN-IIGLLN 88 C A T +K L+ + + E+ L+ L++ ++ ++ Sbjct: 33 CLARKDGTDDFYQLKILTLEERGDQGIESQEERQGKMLLHTEYSLLSLLHTQDGVVHHHG 92 Query: 89 AFTPQRNL------------EEFQDVYLVME-LMDANLCQ------------VIQMDLDH 123 F + + + + LV++ L + + + L Sbjct: 93 LFQDRTCEIVEDTESSRMVKKMKKRICLVLDCLCAHDFSDKTADLINLQHYVIKEKRLSE 152 Query: 124 DRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCT-LKILDFGLARTA-GTTFMMT 181 + Y ++ ++ LH I+HRDLK N+V+ + I +F L + ++ Sbjct: 153 RETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEGDLLK 212 Query: 182 PYVVTRYYRAPEVILGMGY-TENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLG 240 + Y +P+V+ G Y + D+W++G ++ M+ G F + + + KI Sbjct: 213 DQRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPFYDSIPQELFRKI----- 267 Query: 241 TPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKM 300 R + + L+ K+ Sbjct: 268 ------------------------------------KAAEYTIPEDGRVSENTVCLIRKL 291 Query: 301 LVIDPEQRISVDEALK 316 LV+DP+QR++ + L+ Sbjct: 292 LVLDPQQRLAAADVLE 307 >4BTF-A nrPDB Length = 469 Score = 130 bits (327), Expect = 9e-31, Method: Composition-based stats. Identities = 49/236 (20%), Positives = 88/236 (37%), Gaps = 20/236 (8%) Query: 50 VAIKKLSRPFQNVTHAKRAY--REFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVME 107 V IK + P R E K MK + NI+ + Q + + +VME Sbjct: 221 VTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICIDQT--VKPPEFSIVME 278 Query: 108 LMDANLCQVI---QMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLK 164 + + + + DL S L+ + G+ LH + +HR++ S+ +V +K Sbjct: 279 YCELGTLRELLDREKDLTMSVRSLLVLRAARGLYRLHHSETLHRNISSSSFLVAGGYQVK 338 Query: 165 ILDFGLARTAGTTFMMTPYVVTRY-----YRAPEVILG--MGYTENVDIWSVGCIMGEMI 217 + F L++T + Y +PE + Y +I+S G ++ E+ Sbjct: 339 LAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDIKAEIYSFGIVLWEIA 398 Query: 218 RGGVLFPGTDHIDQWNKIIEQ-----LGTPSPSFMQRLQPTVRNY-VENRPRYTGY 267 G + F G D + E +G P ++ + R + RP G Sbjct: 399 TGKIPFEGCDSKKIRELVAEDKKQEPVGQDCPELLREIINECRAHEPSQRPSVDGI 454 >4M69-B nrPDB Length = 283 Score = 130 bits (327), Expect = 9e-31, Method: Composition-based stats. Identities = 49/236 (20%), Positives = 88/236 (37%), Gaps = 20/236 (8%) Query: 50 VAIKKLSRPFQNVTHAKRAY--REFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVME 107 V IK + P R E K MK + NI+ + Q + + +VME Sbjct: 35 VTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICIDQT--VKPPEFSIVME 92 Query: 108 LMDANLCQVI---QMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLK 164 + + + + DL S L+ + G+ LH + +HR++ S+ +V +K Sbjct: 93 YCELGTLRELLDREKDLTMSVRSLLVLRAARGLYRLHHSETLHRNISSSSFLVAGGYQVK 152 Query: 165 ILDFGLARTAGTTFMMTPYVVTRY-----YRAPEVILG--MGYTENVDIWSVGCIMGEMI 217 + F L++T + Y +PE + Y +I+S G ++ E+ Sbjct: 153 LAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDIKAEIYSFGIVLWEIA 212 Query: 218 RGGVLFPGTDHIDQWNKIIEQ-----LGTPSPSFMQRLQPTVRNY-VENRPRYTGY 267 G + F G D + E +G P ++ + R + RP G Sbjct: 213 TGKIPFEGCDSKKIRELVAEDKKQEPVGQDCPELLREIINECRAHEPSQRPSVDGI 268 >2CHL-A nrPDB Length = 351 Score = 130 bits (327), Expect = 1e-30, Method: Composition-based stats. Identities = 51/289 (17%), Positives = 104/289 (35%), Gaps = 36/289 (12%) Query: 11 VEVGDTNFTIHSR--------YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNV 62 V++G N S + + IG G G + + T + VAIK Sbjct: 11 VDLGTENLYFQSMGVLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKL----EPMK 66 Query: 63 THAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQ---M 119 + A + + E++ K + + I + F P +V+EL+ +L + Sbjct: 67 SRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNA-----MVLELLGPSLEDLFDLCDR 121 Query: 120 DLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCT-----LKILDFGLARTA 174 + + Q++ ++++HS +I+RD+KP N ++ + I+DF LA+ Sbjct: 122 TFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEY 181 Query: 175 GT--------TFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPG- 225 T Y + LG + D+ ++G + +RG + + G Sbjct: 182 IDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGL 241 Query: 226 --TDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRL 272 +++ KI + + P + Y+ R + Sbjct: 242 KADTLKERYQKIGDTKRATPIEVLCENFPEMATYLRYVRRLDFFEKPDY 290 >5X1R-A nrPDB Length = 302 Score = 130 bits (326), Expect = 1e-30, Method: Composition-based stats. Identities = 60/274 (21%), Positives = 106/274 (38%), Gaps = 44/274 (16%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKK-----LSRPFQNVTHAKRAYR-------- 70 + IG G GIV AYD ++ +AIK+ L++ +++ R R Sbjct: 23 FEIQEAIGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAKRNDDLSIGLRGERFGKTFQAG 82 Query: 71 ------EFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQ----MD 120 E +L+ +H ++ +L R EE Y+ + + +Q Sbjct: 83 LNSFIQEARLLARFSHPGLLHVL------RFWEENGTAYMGTQFYSGTTLKNLQAQQPEK 136 Query: 121 LDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMM 180 +D + LL + I +H G +HRD+ NI ++ +LDFG AR Sbjct: 137 IDEAWIRRLLPPLFSAINTIHQEGYLHRDISLDNIQIQESQLPVLLDFGSARKEIGNLSD 196 Query: 181 TPYVVTRYYRAPEVILGMGYTENV--------DIWSVGCIMGEMIRGGVLFPGT--DHID 230 +V + AP YTEN DI+++G ++ +I G D Sbjct: 197 ETEIVLKPGFAP----IEQYTENSDGEQGPWTDIYALGAVLHTLIVGSPPPVSVVRSIED 252 Query: 231 QWNKIIEQLGTP-SPSFMQRLQPTVRNYVENRPR 263 + + E+ SP ++ + + E+RP+ Sbjct: 253 SYQPLTERRPAGYSPELLRTVDRALALKPEDRPQ 286 >5J0A-A nrPDB Length = 300 Score = 130 bits (326), Expect = 1e-30, Method: Composition-based stats. Identities = 67/310 (21%), Positives = 113/310 (36%), Gaps = 56/310 (18%) Query: 34 AQGI---VCAAYDTITQ---QNVAIKKLSRPFQN---VTHAKRAYREFKLMKLVNHKNII 84 G V + A+KK++ + + KR E K++K ++H NI+ Sbjct: 18 GFGTGVNVYLMKRSPRGLSHSPWAVKKINPICNDHYRSVYQKRLMDEAKILKSLHHPNIV 77 Query: 85 GLLNAFTPQRNLEEFQDVYLVMEL-MDANLCQVIQMD-------LDHDRMSYLLYQMLCG 136 G AFT + + L ME + +L +I+ + + M G Sbjct: 78 G-YRAFTEAND----GSLCLAMEYGGEKSLNDLIEERYKASQDPFPAAIILKVALNMARG 132 Query: 137 IKHLH-SAGIIHRDLKPSNIVVKADC-TLKILDFGLARTAGTTFMMTP----YVVTRYYR 190 +K+LH ++H D+K SN+V+K D T+KI D G++ +T Y+ T ++ Sbjct: 133 LKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMEVTDPEACYIGTEPWK 192 Query: 191 APEVILGMGY-TENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQR 249 E + G T+ DI++ G + EM+ L P + Sbjct: 193 PKEAVEENGVITDKADIFAFGLTLWEMMT--------------------LSIPHINLSND 232 Query: 250 LQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRI 309 + + E+ Y G P N + L S DP+ R Sbjct: 233 DDDEDKTFDESDFDDEAYYAA----LGTRPPINMEELDESYQKVIELFSVCTNEDPKDRP 288 Query: 310 SVD---EALK 316 S EAL+ Sbjct: 289 SAAHIVEALE 298 >4MWI-A nrPDB Length = 294 Score = 129 bits (324), Expect = 2e-30, Method: Composition-based stats. Identities = 49/226 (21%), Positives = 89/226 (39%), Gaps = 23/226 (10%) Query: 50 VAIKKLSR--PFQNVTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVME 107 VAIK + + +E K MK NI+ + + +VME Sbjct: 50 VAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTPPQFS--IVME 107 Query: 108 LMDANLCQVI---QMDLDHDRMSYLLYQMLCGIKHLHSAGI--IHRDLKPSNIVVKADCT 162 + + + + DL + L+ G+ LH + +H ++ SN +V Sbjct: 108 YCELGTLRELLDREKDLTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQ 167 Query: 163 LKILDFGLART-----AGTTFMMTPYVVTRYYRAPEVILG--MGYTENVDIWSVGCIMGE 215 +K+ F L +T GTT T V + Y +P+ + Y +I+S G ++ E Sbjct: 168 VKLAGFELRKTQTSMSLGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWE 227 Query: 216 MIRGGVLFPGTDHIDQWNKII------EQLGTPSPSFMQRLQPTVR 255 + G + F G + ++ K++ E LG PS ++ + R Sbjct: 228 IATGDIPFQGCNS-EKIRKLVAVKRQQEPLGEDCPSELREIIDECR 272 >4XHH-A nrPDB Length = 403 Score = 125 bits (315), Expect = 2e-29, Method: Composition-based stats. Identities = 49/253 (19%), Positives = 103/253 (40%), Gaps = 26/253 (10%) Query: 17 NFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMK 76 + + ++ R IGSG+ G + + I+ + VAI R + + E ++ K Sbjct: 2 DLRVGRKFRIGRKIGSGSFGDIYHGTNLISGEEVAI----RLESIRSRHPQLDYESRVYK 57 Query: 77 LVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVI---QMDLDHDRMSYLLYQM 133 ++ I + F + +V++L+ +L + + L QM Sbjct: 58 YLSGGVGIPFIRWFGREGEYNA-----MVIDLLGPSLEDLFNYCHRKFSFKTVIMLALQM 112 Query: 134 LCGIKHLHSAGIIHRDLKPSNIVVK---ADCTLKILDFGLARTAGT--------TFMMTP 182 +C ++++H IHRD+KP N ++ T+ ++DFGL++ Sbjct: 113 ICRVQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKS 172 Query: 183 YVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPG---TDHIDQWNKIIEQL 239 T Y + LG+ + D+ S+G ++ +G + + G T ++++I+E+ Sbjct: 173 LTGTARYASVNTHLGIEQSRRDDLESLGYMLIYFCKGSLPWQGLKATTKKQKYDRILEKK 232 Query: 240 GTPSPSFMQRLQP 252 S + P Sbjct: 233 LCISVETLCAGLP 245 >5VDK-A nrPDB Length = 297 Score = 125 bits (313), Expect = 4e-29, Method: Composition-based stats. Identities = 54/337 (16%), Positives = 106/337 (31%), Gaps = 92/337 (27%) Query: 12 EVGDTNFTIHSRYIN----LRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKR 67 E G TN + SRY + IG G G V + AIK+ + F +++ Sbjct: 3 EFGSTN--MASRYEKEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENS 60 Query: 68 AYREFKLMKLV-NHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMD------ 120 A E ++ +H +++ +++ ++ E + Q + Sbjct: 61 ALHEVYAHAVLGHHPHVVRYYSSWAEDDHMIIQN------EYCNGGSLQAAISENTKSGN 114 Query: 121 -LDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNI-----------------------V 156 + ++ +L Q+ G+ ++H++ ++H D+KPSNI Sbjct: 115 HFEEPKLKDILLQISLGLNYIHNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWF 174 Query: 157 VKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVIL-GMGYTENVDIWSVGCIMGE 215 + A+ KI D G A + + A E++ + DI+++G + Sbjct: 175 LSANVMYKIGDLGHATSIN---KPKVEEGDSRFLANEILQEDYRHLPKADIFALGLTIA- 230 Query: 216 MIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPD 275 V E+ P Sbjct: 231 --------------------------------------VAAGAESLPTNGAA------WH 246 Query: 276 GLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVD 312 + + + + +LL M+ D EQR S Sbjct: 247 HIRKGNFPDVPQELSESFSSLLKNMIQPDAEQRPSAA 283 >4XHL-A nrPDB Length = 394 Score = 124 bits (312), Expect = 6e-29, Method: Composition-based stats. Identities = 49/253 (19%), Positives = 102/253 (40%), Gaps = 26/253 (10%) Query: 17 NFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMK 76 + + ++ R IGSG+ G + + I+ + VAI R + + E ++ + Sbjct: 2 DLRVGRKFRIGRKIGSGSFGDIYHGTNLISGEEVAI----RLESIRSRHPQLDYESRVYR 57 Query: 77 LVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVI---QMDLDHDRMSYLLYQM 133 ++ I + F + +V++L+ +L + + L QM Sbjct: 58 YLSGGVGIPFIRWFGREGEYNA-----MVIDLLGPSLEDLFNYCHRRFSFKTVIMLALQM 112 Query: 134 LCGIKHLHSAGIIHRDLKPSNIVVK---ADCTLKILDFGLARTAGT--------TFMMTP 182 C I+++H IHRD+KP N ++ T+ ++DFGL++ Sbjct: 113 FCRIQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKS 172 Query: 183 YVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPG---TDHIDQWNKIIEQL 239 T Y + LG+ + D+ S+G ++ +G + + G T ++++I+E+ Sbjct: 173 LTGTARYASVNTHLGIEQSRRDDLESLGYVLIYFCKGSLPWQGLKATTKKQKYDRIMEKK 232 Query: 240 GTPSPSFMQRLQP 252 S + P Sbjct: 233 LNVSVETLCSGLP 245 >4JRN-A nrPDB Length = 372 Score = 123 bits (309), Expect = 1e-28, Method: Composition-based stats. Identities = 57/330 (17%), Positives = 105/330 (31%), Gaps = 87/330 (26%) Query: 29 PIGSGAQGIVCAAYDTITQQNVAIKKL-------SRPFQNVTHAKRAYREFKLMKLVNH- 80 P+GSG V A D T + +A+K ++ YR F L K Sbjct: 75 PLGSGGFATVYEATDVETNEELAVKVFMSEKEPTDETMLDLQRESSCYRNFSLAKTAKDA 134 Query: 81 ---------KNIIGLLN-----AFTPQRNLEEFQDVYLVMELMDANLCQVI--------- 117 +++ L + +L+M +A++ +VI Sbjct: 135 QESCRFMVPSDVVMLEGQPASTEVVIGLTTRWVPNYFLLMMRAEADMSKVISWVFGDASV 194 Query: 118 -QMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGT 176 + + YL Q + + ++ + GI+H D+KP+N ++ D L + DFG R + Sbjct: 195 NKSEFGLVVRMYLSSQAIKLVANVQAQGIVHTDIKPANFLLLKDGRLFLGDFGTYRINNS 254 Query: 177 TFMMTPYVVTRYYRAPE---VILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWN 233 + T Y PE G+ YT D W +G + + P Sbjct: 255 VGRA---IGTPGYEPPERPFQATGITYTFPTDAWQLGITLYCIWCKERPTPA-------- 303 Query: 234 KIIEQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDA 293 DG++ + + Sbjct: 304 -----------------------------------------DGIWDYLHFADCPSTPELV 322 Query: 294 RNLLSKMLVIDPEQRISVDEALKHEYINVW 323 ++L+ +L DP++R+ +AL+ Sbjct: 323 QDLIRSLLNRDPQKRMLPLQALETAAFKEM 352 >1CSN-A nrPDB Length = 298 Score = 122 bits (307), Expect = 2e-28, Method: Composition-based stats. Identities = 49/268 (18%), Positives = 100/268 (37%), Gaps = 31/268 (11%) Query: 13 VGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREF 72 + N + Y R IG G+ G++ + + Q VAIK R + + YR + Sbjct: 1 MSGQNNVVGVHYKVGRRIGEGSFGVIFEGTNLLNNQQVAIKFEPRR-SDAPQLRDEYRTY 59 Query: 73 KLMKLVNH-KNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQ---MDLDHDRMSY 128 KL+ N+ +E LV++L+ +L ++ ++ Sbjct: 60 KLLAGCTGIPNV---------YYFGQEGLHNVLVIDLLGPSLEDLLDLCGRKFSVKTVAM 110 Query: 129 LLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCT-----LKILDFGLARTAGT------- 176 QML ++ +H +++RD+KP N ++ + + ++DFG+ + Sbjct: 111 AAKQMLARVQSIHEKSLVYRDIKPDNFLIGRPNSKNANMIYVVDFGMVKFYRDPVTKQHI 170 Query: 177 -TFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPG---TDHIDQW 232 T Y + LG + D+ ++G + +RG + + G + ++ Sbjct: 171 PYREKKNLSGTARYMSINTHLGREQSRRDDLEALGHVFMYFLRGSLPWQGLKAATNKQKY 230 Query: 233 NKIIEQL-GTPSPSFMQRLQPTVRNYVE 259 +I E+ TP Y+ Sbjct: 231 ERIGEKKQSTPLRELCAGFPEEFYKYMH 258 >5OAT-A nrPDB Length = 411 Score = 120 bits (302), Expect = 8e-28, Method: Composition-based stats. Identities = 64/295 (21%), Positives = 99/295 (33%), Gaps = 57/295 (19%) Query: 26 NLRPIGSGAQGIVCAAYDTITQQN-----VAIKKL---SRPFQNVTHAKRAYRE------ 71 +PI G G+V +A + + A+K + ++ K YRE Sbjct: 15 LGKPIAKGTNGVVYSAKVKDDETDDNKYPFALKMMFNYDIQENSMEILKAMYRETVPARM 74 Query: 72 -----------FKLMKLVNH----KNIIGLLNAFTP-----------QRNLEEFQDVYLV 105 +L H NI+ + + FT ++L+ Sbjct: 75 YYSNHDLNNWEIELANRRKHLPPHPNIVAIFSVFTDLYPAALPPRLHPEGEGRNMSLFLL 134 Query: 106 MELMDANLCQVIQMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK----ADC 161 M+ D NL + LL Q+L G+ H+ + GI HRDLK N+++ Sbjct: 135 MKRYDCNLQSFLSTAPSTRTSLLLLAQLLEGVAHMTAHGIAHRDLKSDNLLLDTSEPESP 194 Query: 162 TLKILDFGLARTAGTTFMMTPYV-------VTRYYRAPEVILGMGYTE------NVDIWS 208 L I DFG T + PY APE+I T D+W+ Sbjct: 195 ILVISDFGCCLADKTNGLSLPYTSYEMDKGGNTALMAPEIICQKPGTFSVLNYSKADLWA 254 Query: 209 VGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENRPR 263 VG I E+ F G + +N L +Q V N ++ P Sbjct: 255 VGAIAYEIFNCHNPFYGPSRLKNFNYKEGDLPKLPDEVPTVIQALVANLLKRNPN 309 >5M07-A nrPDB Length = 276 Score = 120 bits (301), Expect = 1e-27, Method: Composition-based stats. Identities = 39/209 (18%), Positives = 80/209 (38%), Gaps = 29/209 (13%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQ-NVTHAKRAYREFKLMKLVNHKN 82 Y +R +G+ A G V A+K LS + +R RE ++ + H + Sbjct: 32 YTVVRMLGASAMGEVYLVQHPGFPGWQALKVLSPAMAADDEFRRRFQRETEVAARLFHPH 91 Query: 83 IIGLLNAFTPQRNLEEFQDVYLVMELMDA-----NLCQVIQMDLDHDRMSYLLYQMLCGI 137 I+ + + E +++ M+ +D ++ L + ++ + + Sbjct: 92 ILEVHD------RGEFDGQLWIAMDYVDGIDATQHMADRFPAVLPVGEVLAIVTAVAGAL 145 Query: 138 KHLHSAGIIHRDLKPSNIVVKA----DCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPE 193 + H G++HRD+ P+N+V+ + D + + DFG+A Y APE Sbjct: 146 DYAHQRGLLHRDVNPANVVLTSQSAGDQRILLADFGIASQ-------------PSYPAPE 192 Query: 194 VILGMGYTENVDIWSVGCIMGEMIRGGVL 222 + G D +++ + G Sbjct: 193 LSAGADVDGRADQYALALTAIHLFAGAPP 221 >4NT4-A nrPDB Length = 312 Score = 120 bits (300), Expect = 1e-27, Method: Composition-based stats. Identities = 47/261 (18%), Positives = 98/261 (37%), Gaps = 34/261 (13%) Query: 18 FTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKL 77 + + + IG G G + + ++VAIK + + + E++ KL Sbjct: 8 LMVGPNFRVGKKIGCGNFGELRLGKNLYNNEHVAIKMEPMKSKAP----QLHLEYRFYKL 63 Query: 78 V-NHKN-----IIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQ---MDLDHDRMSY 128 + +H + I + + T +V+EL+ +L + + Sbjct: 64 LGSHADNAPDGIPRIYHLGTCGGRYNA-----MVLELLGLSLEDLFNICARKFSLKTVLM 118 Query: 129 LLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCT-----LKILDFGLARTAGT------- 176 + Q+L I+++HS +I+RD+KP N ++ T + I+DFGLA+ Sbjct: 119 IAKQLLHRIEYVHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRHI 178 Query: 177 -TFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPG---TDHIDQW 232 T Y + +G + D+ ++G + +RG + + G +++ Sbjct: 179 PYREHKSLTGTARYMSINTHMGREQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERY 238 Query: 233 NKIIEQLGTPSPSFMQRLQPT 253 KI + + P Sbjct: 239 QKIGDTKRATPIEVLCDGHPE 259 >2CMW-A nrPDB Length = 310 Score = 119 bits (299), Expect = 2e-27, Method: Composition-based stats. Identities = 47/249 (18%), Positives = 90/249 (36%), Gaps = 31/249 (12%) Query: 26 NLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIG 85 + IG G G + + T + VAIK + + + E++ K + Sbjct: 4 VGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAP----QLHLEYRFYKQLGSA---- 55 Query: 86 LLNAFTPQRNLEEFQDVY--LVMELMDANLCQVIQ---MDLDHDRMSYLLYQMLCGIKHL 140 PQ Y +V+EL+ +L + + + Q+L ++++ Sbjct: 56 --GEGLPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYV 113 Query: 141 HSAGIIHRDLKPSNIVVKADCTLK-----ILDFGLARTAGT--------TFMMTPYVVTR 187 HS +I+RD+KP N ++ K I+DFGLA+ T Sbjct: 114 HSKNLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTA 173 Query: 188 YYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPG---TDHIDQWNKIIEQLGTPSP 244 Y + LG + D+ ++G + +RG + + G +++ KI + Sbjct: 174 RYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRNTPI 233 Query: 245 SFMQRLQPT 253 + P Sbjct: 234 EALCENFPE 242 >2C47-A nrPDB Length = 313 Score = 119 bits (298), Expect = 2e-27, Method: Composition-based stats. Identities = 43/254 (16%), Positives = 93/254 (36%), Gaps = 28/254 (11%) Query: 19 TIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLV 78 ++ + + IG G G + + T + VAIK + + + E++ K + Sbjct: 1 SMGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAP----QLHLEYRFYKQL 56 Query: 79 NHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQ---MDLDHDRMSYLLYQMLC 135 + + +V+EL+ +L + + + Q++ Sbjct: 57 S-----ATEGVPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLIT 111 Query: 136 GIKHLHSAGIIHRDLKPSNIVVKADCT-----LKILDFGLARTAGT--------TFMMTP 182 ++++H+ +I+RD+KP N +V T + I+DFGLA+ Sbjct: 112 RMEYVHTKSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKS 171 Query: 183 YVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPG---TDHIDQWNKIIEQL 239 T Y + LG + D+ ++G + +RG + + G +++ KI + Sbjct: 172 LTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTK 231 Query: 240 GTPSPSFMQRLQPT 253 + P Sbjct: 232 RATPIEVLCENFPE 245 >2PZI-A nrPDB Length = 681 Score = 116 bits (290), Expect = 2e-26, Method: Composition-based stats. Identities = 47/201 (23%), Positives = 87/201 (43%), Gaps = 11/201 (5%) Query: 19 TIHSRYINLRPIGSGAQGIVCAAYDT-ITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKL 77 + +Y I G G + A D + + V +K L A + + Sbjct: 77 IVAGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAE-RQFLAE 135 Query: 78 VNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDA-NLCQVIQMDLDHDRMSYLLYQMLCG 136 V H +I+ + N F + Y+VME + +L + L L ++L Sbjct: 136 VVHPSIVQIFN-FVEHTDRHGDPVGYIVMEYVGGQSLKRSKGQKLPVAEAIAYLLEILPA 194 Query: 137 IKHLHSAGIIHRDLKPSNIVVKADCTLKILDFG-LARTAGTTFMMTPYVVTRYYRAPEVI 195 + +LHS G+++ DLKP NI++ + LK++D G ++R ++ T ++APE++ Sbjct: 195 LSYLHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINSFGYLY----GTPGFQAPEIV 249 Query: 196 LGMGYTENVDIWSVGCIMGEM 216 T DI++VG + + Sbjct: 250 RTGP-TVATDIYTVGRTLAAL 269 >4Y12-A nrPDB Length = 375 Score = 115 bits (289), Expect = 2e-26, Method: Composition-based stats. Identities = 47/201 (23%), Positives = 87/201 (43%), Gaps = 11/201 (5%) Query: 19 TIHSRYINLRPIGSGAQGIVCAAYDT-ITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKL 77 + +Y I G G + A D + + V +K L A + + Sbjct: 116 IVAGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAE-RQFLAE 174 Query: 78 VNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDA-NLCQVIQMDLDHDRMSYLLYQMLCG 136 V H +I+ + N F + Y+VME + +L + L L ++L Sbjct: 175 VVHPSIVQIFN-FVEHTDRHGDPVGYIVMEYVGGQSLKRSKGQKLPVAEAIAYLLEILPA 233 Query: 137 IKHLHSAGIIHRDLKPSNIVVKADCTLKILDFG-LARTAGTTFMMTPYVVTRYYRAPEVI 195 + +LHS G+++ DLKP NI++ + LK++D G ++R ++ T ++APE++ Sbjct: 234 LSYLHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINSFGYLY----GTPGFQAPEIV 288 Query: 196 LGMGYTENVDIWSVGCIMGEM 216 T DI++VG + + Sbjct: 289 RTGP-TVATDIYTVGRTLAAL 308 >5CEK-A nrPDB Length = 263 Score = 108 bits (270), Expect = 3e-24, Method: Composition-based stats. Identities = 47/289 (16%), Positives = 96/289 (33%), Gaps = 59/289 (20%) Query: 38 VCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLE 97 V A T + + K P ++ R Y ++L +H NI G++ + Sbjct: 25 VSRALCIHTGRELRCKVF--PIKHYQDKIRPY-----IQLPSHSNITGIVEVILGETKAY 77 Query: 98 EFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVV 157 F + + D + + L + + L Q++ + H H + I+ DLK V Sbjct: 78 VFFEK----DFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVF 133 Query: 158 K--ADCTLKILDFGLARTA-GTTFMMTPYVVTRYYRAPEVILGMG-YT-ENVDIWSVGCI 212 L++ G ++ Y +PE++ G Y+ + D+WS+G + Sbjct: 134 STEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVM 193 Query: 213 MGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRL 272 + ++ G F +D ++KI + + +R+ Sbjct: 194 LYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKARCLIRS---------------- 237 Query: 273 FPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEYIN 321 +L +P +R++ E L H + Sbjct: 238 ---------------------------LLRREPSERLTAPEILLHPWFE 259 >6DC0-A nrPDB Length = 292 Score = 108 bits (270), Expect = 4e-24, Method: Composition-based stats. Identities = 47/289 (16%), Positives = 96/289 (33%), Gaps = 59/289 (20%) Query: 38 VCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLE 97 V A T + + K P ++ R Y ++L +H NI G++ + Sbjct: 22 VSRALCIHTGRELRCKVF--PIKHYQDKIRPY-----IQLPSHSNITGIVEVILGETKAY 74 Query: 98 EFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVV 157 F + + D + + L + + L Q++ + H H + I+ DLK V Sbjct: 75 VFFEK----DFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVF 130 Query: 158 K--ADCTLKILDFGLARTA-GTTFMMTPYVVTRYYRAPEVILGMG-YT-ENVDIWSVGCI 212 L++ G ++ Y +PE++ G Y+ + D+WS+G + Sbjct: 131 STEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVM 190 Query: 213 MGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRL 272 + ++ G F +D ++KI + + +R+ Sbjct: 191 LYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKARCLIRS---------------- 234 Query: 273 FPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEYIN 321 +L +P +R++ E L H + Sbjct: 235 ---------------------------LLRREPSERLTAPEILLHPWFE 256 >3REP-A nrPDB Length = 271 Score = 105 bits (263), Expect = 3e-23, Method: Composition-based stats. Identities = 40/246 (16%), Positives = 89/246 (36%), Gaps = 26/246 (10%) Query: 36 GIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRN 95 G + ++ +K L + ++ E +++ +H N++ +L A Sbjct: 24 GELWKGRWQ--GNDIVVKVLKVRDWSTRKSRDFNEECPRLRIFSHPNVLPVLGACQSPPA 81 Query: 96 LEEFQDVYLVMELMD-ANLCQVIQMD----LDHDRMSYLLYQMLCGIKHLHSAG-IIHR- 148 L+ M +L V+ +D + M G+ LH+ +I R Sbjct: 82 PHPT----LITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFLHTLEPLIPRH 137 Query: 149 DLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGYTE---NVD 205 L ++++ D T +I +A +F + + APE + + D Sbjct: 138 ALNSRSVMIDEDMTARIS---MA-DVKFSFQSPGRMYAPAWVAPEALQKKPEDTNRRSAD 193 Query: 206 IWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTP------SPSFMQRLQPTVRNYVE 259 +WS ++ E++ V F +++ K+ + P SP + ++ + Sbjct: 194 MWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPTIPPGISPHVSKLMKICMNEDPA 253 Query: 260 NRPRYT 265 RP++ Sbjct: 254 KRPKFD 259 >5USZ-A nrPDB Length = 289 Score = 103 bits (258), Expect = 9e-23, Method: Composition-based stats. Identities = 42/277 (15%), Positives = 94/277 (33%), Gaps = 37/277 (13%) Query: 30 IGSGAQGIVCAAYDTITQQ-------NVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKN 82 +G G + V +K L + +N +++ + +M ++HK+ Sbjct: 16 LGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRN--YSESFFEAASMMSKLSHKH 73 Query: 83 IIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQMDLDHDRMSY---LLYQMLCGIK 138 ++ + LV E + +L ++ + + + + + Q+ + Sbjct: 74 LVLNYGVCVC------GDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAAAMH 127 Query: 139 HLHSAGIIHRDLKPSNIVV--------KADCTLKILDFGLARTAGTTFMMTPYVVTRYYR 190 L +IH ++ NI++ +K+ D G++ T ++ + + Sbjct: 128 FLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERI---PWV 184 Query: 191 APEVILG-MGYTENVDIWSVGCIMGEMIRGG-VLFPGTDHIDQWNKIIEQLGTPSP---S 245 PE I D WS G + E+ GG D + ++ P+P Sbjct: 185 PPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKAAE 244 Query: 246 FMQRLQPTVRNYVENRPRYTG--YSFDRLFPDGLFPN 280 + + ++RP + + LF L P Sbjct: 245 LANLINNCMDYEPDHRPSFRAIIRDLNSLFTPDLVPR 281 >6EQI-C nrPDB Length = 433 Score = 103 bits (256), Expect = 1e-22, Method: Composition-based stats. Identities = 58/313 (18%), Positives = 95/313 (30%), Gaps = 68/313 (21%) Query: 26 NLRPIGSGAQGIVCAAYDT-----ITQQNVAIKKL---SRPFQNVTHAKRAYRE------ 71 PI G +V +A +A+K + + K YRE Sbjct: 19 LGEPIAKGCNAVVYSAKLKNVQSNKLAHQLAVKMMFNYDVESNSTAILKAMYRETVPAMS 78 Query: 72 ---------FKLMKLVN-----HKNIIGLLNAFTP---------------------QRNL 96 + + H NI+ + + F Sbjct: 79 YFFNQNLFNIENISDFKIRLPPHPNIVRMYSVFADRIPDLQCNKQLYPEALPPRINPEGS 138 Query: 97 EEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQML-CGIKHLHSAGIIHRDLKPSNI 155 ++LVM+ D L + ++ + R S LL L + H++ I HRDLK NI Sbjct: 139 GRNMSLFLVMKRYDCTLKEYLRDKTPNMRSSILLLSQLLEAVAHMNIHNISHRDLKSDNI 198 Query: 156 VVKAD-----CTLKILDFGLARTAGTTFMMTPYV-------VTRYYRAPEVILGMGYT-- 201 +V T+ I DFG ++ PY R APE+ T Sbjct: 199 LVDLSEGDAYPTIVITDFGCCLCDKQNGLVIPYRSEDQDKGGNRALMAPEIANAKPGTFS 258 Query: 202 ----ENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNY 257 + D+W+VG I E+ F E+ P + + + + Sbjct: 259 WLNYKKSDLWAVGAIAYEIFNIDNPFYDKTMKLLSKSYKEEDLPELPDTIPFIIRNLVSN 318 Query: 258 VENRPRYTGYSFD 270 + +R D Sbjct: 319 MLSRSTNKRLDCD 331 >4L00-A nrPDB Length = 304 Score = 100 bits (249), Expect = 1e-21, Method: Composition-based stats. Identities = 44/290 (15%), Positives = 98/290 (33%), Gaps = 33/290 (11%) Query: 19 TIHSRYINLRPIGSGAQGIVCAAY------DTITQQNVAIKKLSRPFQ-NVTHAKRAYRE 71 + + +G G + + + D T + IK + + + A+ E Sbjct: 22 ILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFE 81 Query: 72 F-KLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMD----LDHDRM 126 +M+ V+HK+I+ L + +V E ++ + L Sbjct: 82 AASMMRQVSHKHIVYLYGVCVRD------VENIMVEEFVEGGPLDLFMHRKSDVLTTPWK 135 Query: 127 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCT-------LKILDFGLARTAGTTFM 179 + Q+ + +L ++H ++ N+++ + +K+ D G+ T Sbjct: 136 FKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGI---PITVLS 192 Query: 180 MTPYVVTRYYRAPEVILGMG-YTENVDIWSVGCIMGEM-IRGGVLFPGTD--HIDQWNKI 235 + + APE + + D WS G + E+ G + +++ + Sbjct: 193 RQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYES 252 Query: 236 IEQLGTPSPSFMQRLQPTVRNY-VENRPRYTGYSFDRLFPDGLFPNDNNQ 284 + TPS + L NY RP + D + P+ ++ Sbjct: 253 RCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSE 302 >5UV4-A nrPDB Length = 311 Score = 100 bits (248), Expect = 1e-21, Method: Composition-based stats. Identities = 38/208 (18%), Positives = 73/208 (35%), Gaps = 21/208 (10%) Query: 28 RPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLL 87 IG G A + +K L F K RE K + V H N++ L Sbjct: 31 EIIGRSCHGTSYKAT-LDNGYMLTVKWLKEGFAKSK--KEFSREIKKLGSVRHPNLVPLR 87 Query: 88 NAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDH--------DRMSYLLYQMLCGIKH 139 + + E ++ + DA + D + + + + + Sbjct: 88 GYYWGPKEHERI----MISDYADATSLSTYLSEFDERNLPPLSAGQRLNIAIDIARCLDY 143 Query: 140 LHSAGII-HRDLKPSNIVV-KADCTLKILDFGLARTAGTTFMMTPY--VVTRYYRAPE-- 193 LH+ +I H ++K SN+++ + + + D+ L R M Y PE Sbjct: 144 LHNERVIPHGNIKSSNVLIQNSTPSALVTDYSLHRLMTPIGMAEQVLNAGALGYSPPEFS 203 Query: 194 VILGMGYTENVDIWSVGCIMGEMIRGGV 221 + D+++ G I+ E++ G + Sbjct: 204 STSKPCPSLKSDVYAFGVILLELLTGKI 231 >4L68-A nrPDB Length = 340 Score = 96.6 bits (239), Expect = 2e-20, Method: Composition-based stats. Identities = 55/286 (19%), Positives = 99/286 (34%), Gaps = 39/286 (13%) Query: 36 GIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYR-EFKLMKLVNHKNIIGLLNAFTPQR 94 G A +A+K LS +R +R E + + H N+ LL + Sbjct: 54 GTTYKAL-LPDGSALAVKHLSTCKLG----EREFRYEMNQLWELRHSNLAPLLGFCVVE- 107 Query: 95 NLEEFQDVYLVMELMDANLCQVI----QMDLDHDRMSYLLYQMLCGIKHLHS---AGIIH 147 ++ +LV + M + + +LD + G+ LH I+H Sbjct: 108 -----EEKFLVYKYMSNGTLHSLLDSNRGELDWSTRFRIGLGAARGLAWLHHGCRPPILH 162 Query: 148 RDLKPSNIVVKADCTLKILDFGLARTA-----GTTFMMTPYVVTRYYRAPEVILGMGYTE 202 +++ S I++ D +I+D GLAR + MT + Y APE M + Sbjct: 163 QNICSSVILIDEDFDARIIDSGLARLMVPSDNNESSFMTGDLGEFGYVAPEYSTTMLASL 222 Query: 203 NVDIWSVGCIMGEMIR-----GGVLFPGT-----DHIDQWNKIIEQL-----GTPSPSFM 247 D++ +G ++ E+ GG F G+ ++ +I E G + Sbjct: 223 KGDVYGLGVVLLELATGLKAVGGEGFKGSLVDWVKQLESSGRIAETFDENIRGKGHDEEI 282 Query: 248 QRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDA 293 + N V +RP+ F + + D Sbjct: 283 SKFVEIALNCVSSRPKERWSMFQAYQSLKAIAEKQGYSFSEQDDDF 328 >6J6I-B nrPDB Length = 351 Score = 93.5 bits (231), Expect = 1e-19, Method: Composition-based stats. Identities = 39/192 (20%), Positives = 67/192 (34%), Gaps = 23/192 (11%) Query: 47 QQNVAIKKLSRPF--QNVTHAKRAYREFKL-MKLVNHKNIIGLLNAFTPQRNLEEFQDVY 103 ++ IK+ S K Y + L ++ NH N + LL EF Sbjct: 81 DRSYMIKRFSEDEITGKRHRVKEVYNDIVLSARMSNHSNFLQLLGCCL------EFPFPV 134 Query: 104 LVMELMDANLCQVI--------QMDLDHDRMSYLLYQMLCGIKHLHS---AGIIHRDLKP 152 LV E + + L + ++ + +LH+ IIHRD+KP Sbjct: 135 LVFEFAEHGAMNQRGGVIVNGEESLLPWSVRLKIGKEIANAVTYLHTAFPKIIIHRDVKP 194 Query: 153 SNIVVKADCTLKILDFGLARTAGTTFMMTP---YVVTRYYRAPEVILGMGYTENVDIWSV 209 ++ + + T K+ D + + + T Y P TE D++S Sbjct: 195 MHVFLDKNWTAKLSDLSFSISLPEGKSRIEAEWVLGTFGYIDPLYHKTCFVTEYTDVYSF 254 Query: 210 GCIMGEMIRGGV 221 G + +I G Sbjct: 255 GICLLVIITGKP 266 >5C01-A nrPDB Length = 342 Score = 89.3 bits (220), Expect = 2e-18, Method: Composition-based stats. Identities = 37/242 (15%), Positives = 77/242 (31%), Gaps = 28/242 (11%) Query: 41 AYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQ 100 D + V +K L ++ A Y LM V+H ++ + Sbjct: 101 GRDRGQELRVVLKVLDPSHHDIALA--FYETASLMSQVSHTHLAFVHGVCVRGP------ 152 Query: 101 DVYLVMELMDANLCQVI----QMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIV 156 + +V E ++ V + + + Q+ + +L + ++H ++ NI+ Sbjct: 153 ENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNIL 212 Query: 157 VKADCT-------LKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILG--MGYTENVDIW 207 + +K+ D G+ A V + APE + G + +D W Sbjct: 213 LARLGLAEGTSPFIKLSDPGVGLGA---LSREERVERIPWLAPECLPGGANSLSTAMDKW 269 Query: 208 SVGCIMGEM-IRGGVLFP--GTDHIDQWNKIIEQLGTP-SPSFMQRLQPTVRNYVENRPR 263 G + E+ G + + + +L P P + RP Sbjct: 270 GFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPS 329 Query: 264 YT 265 + Sbjct: 330 FR 331 >4WOV-A nrPDB Length = 317 Score = 89.3 bits (220), Expect = 2e-18, Method: Composition-based stats. Identities = 37/242 (15%), Positives = 77/242 (31%), Gaps = 28/242 (11%) Query: 41 AYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQ 100 D + V +K L ++ A Y LM V+H ++ + Sbjct: 78 GRDRGQELRVVLKVLDPSHHDIALA--FYETASLMSQVSHTHLAFVHGVCVRGP------ 129 Query: 101 DVYLVMELMDANLCQVI----QMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIV 156 + +V E ++ V + + + Q+ + +L + ++H ++ NI+ Sbjct: 130 ENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNIL 189 Query: 157 VKADCT-------LKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILG--MGYTENVDIW 207 + +K+ D G+ A V + APE + G + +D W Sbjct: 190 LARLGLAEGTSPFIKLSDPGVGLGA---LSREERVERIPWLAPECLPGGANSLSTAMDKW 246 Query: 208 SVGCIMGEM-IRGGVLFP--GTDHIDQWNKIIEQLGTP-SPSFMQRLQPTVRNYVENRPR 263 G + E+ G + + + +L P P + RP Sbjct: 247 GFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPS 306 Query: 264 YT 265 + Sbjct: 307 FR 308 >4I94-A nrPDB Length = 300 Score = 87.0 bits (214), Expect = 1e-17, Method: Composition-based stats. Identities = 38/285 (13%), Positives = 92/285 (32%), Gaps = 61/285 (21%) Query: 37 IVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNL 96 +V Q+ +A+K+ +R ++ +++ E K + + + + LL Sbjct: 44 VVYKGK-LENQRRIAVKRFNR--KSWPDSRQFLEEAKAVGQLRNHRMANLLGCC------ 94 Query: 97 EEFQDVYLVMELMDA-----NLCQVIQMDLDHDRMSYLLYQMLCGIKHLHSAG-IIHRDL 150 E ++ L+ E M +L + + + +++ S G ++ DL Sbjct: 95 YEDEERLLIAEFMPNETLAKHLFHWESQPMKWAMRLRVALHIAQALEYCTSKGRALYHDL 154 Query: 151 KPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVG 210 ++ D ++ FGL + + Y + PE + T I+S G Sbjct: 155 NAYRVLFDDDANPRLSCFGLMKNSRDG---KSYSTNLAFTPPEYLRTGRVTPESVIYSFG 211 Query: 211 CIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFD 270 ++ +++ G + P + + +R Sbjct: 212 TLLLDLLSGKHIPPSH---------------------------ALDLIRDR--------- 235 Query: 271 RLFPDGLFPNDNNQNSRRKASDARNLLS---KMLVIDPEQRISVD 312 + D+ + + D L+ + L +P +R + Sbjct: 236 ----NIQMLMDSGLEGQFSSDDGTELIRLASRCLQYEPRERPNPK 276 >2RSV-A nrPDB Length = 403 Score = 85.8 bits (211), Expect = 2e-17, Method: Composition-based stats. Identities = 35/263 (13%), Positives = 101/263 (38%), Gaps = 34/263 (12%) Query: 2 TTAQHQHYTVEVGDTNFTIHSRYINLR-PIGSGAQGIVCAAYDTITQQNV------AIKK 54 + +H VG+ + + + PIG G G + A D + ++V +K Sbjct: 21 SAKRHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKV 79 Query: 55 LS----------RPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYL 104 + +Q ++ + + + + + + + +N + ++ ++ Sbjct: 80 EPSDNGPLFTELKFYQRAAKPEQIQKWIRT-RKLKYLGVPKYWGSGLHDKNGKSYR--FM 136 Query: 105 VMELMDANLCQVIQ---MDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK--A 159 +M+ ++L ++ + + L ++L ++++H +H D+K SN+++ Sbjct: 137 IMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKN 196 Query: 160 DCTLKILDFGLARTAGTTFMMTPYV--------VTRYYRAPEVILGMGYTENVDIWSVGC 211 + ++D+GLA + Y T + + + G+ + D+ +G Sbjct: 197 PDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGY 256 Query: 212 IMGEMIRGGVLFPGTDHIDQWNK 234 M + + G + + ++ + Sbjct: 257 CMIQWLTGHLPWEDNLKDPKYVR 279 >5CLR-A nrPDB Length = 451 Score = 85.8 bits (211), Expect = 3e-17, Method: Composition-based stats. Identities = 33/196 (16%), Positives = 71/196 (36%), Gaps = 27/196 (13%) Query: 39 CAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEE 98 Y + +K + +++T E + + L+ F ++ Sbjct: 96 FKVYALDDGKTYFLKSVKIDAESLTE---FTNEKDTLSKLG-----RLVGTFFNEQTQVH 147 Query: 99 FQDVYLVMELMDANLCQVIQMDLDHD-------RMSYLLYQMLCGIKHLHSAGIIHRDLK 151 Y++ + + L + + ++ + +K H G+IHRDLK Sbjct: 148 ----YILTTFIKGIDLSRYKNALPLNVNLKHFWEVLGIMISVCHQVKQFHELGLIHRDLK 203 Query: 152 PSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMG---YTENVDIWS 208 P NI++ AD ++DFG + + T Y APE+ +++ D+++ Sbjct: 204 PGNIMLDADMQCHLVDFGSS--SSDKEPKPASWGTASYLAPELNAQEDFIAFSQVSDLFA 261 Query: 209 VGCIMGEMIRGGVLFP 224 + + E+ F Sbjct: 262 LAYSLDELFN---PFR 274 >2LAV-A nrPDB Length = 361 Score = 85.1 bits (209), Expect = 5e-17, Method: Composition-based stats. Identities = 35/263 (13%), Positives = 101/263 (38%), Gaps = 34/263 (12%) Query: 2 TTAQHQHYTVEVGDTNFTIHSRYINLR-PIGSGAQGIVCAAYDTITQQNV------AIKK 54 + +H VG+ + + + PIG G G + A D + ++V +K Sbjct: 14 SAKRHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKV 72 Query: 55 LS----------RPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYL 104 + +Q ++ + + + + + + + +N + ++ ++ Sbjct: 73 EPSDNGPLFTELKFYQRAAKPEQIQKWIRT-RKLKYLGVPKYWGSGLHDKNGKSYR--FM 129 Query: 105 VMELMDANLCQVIQ---MDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK--A 159 +M+ ++L ++ + + L ++L ++++H +H D+K SN+++ Sbjct: 130 IMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKN 189 Query: 160 DCTLKILDFGLARTAGTTFMMTPYV--------VTRYYRAPEVILGMGYTENVDIWSVGC 211 + ++D+GLA + Y T + + + G+ + D+ +G Sbjct: 190 PDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGY 249 Query: 212 IMGEMIRGGVLFPGTDHIDQWNK 234 M + + G + + ++ + Sbjct: 250 CMIQWLTGHLPWEDNLKDPKYVR 272 >5UU1-A nrPDB Length = 324 Score = 83.1 bits (204), Expect = 2e-16, Method: Composition-based stats. Identities = 35/233 (15%), Positives = 87/233 (37%), Gaps = 36/233 (15%) Query: 21 HSRYINLRPIGSGAQGIVCAAY-----DTITQQNVAI------------KKLSRPFQNVT 63 ++++ + IGSG G++ A+ + + V + K R + Sbjct: 15 GNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDC 74 Query: 64 HAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQV--IQMDL 121 K R K +++ I + + ++ ++VME + +L ++ Sbjct: 75 IKKWIER-----KQLDYLGIPLFYGSGLTEFKGRSYR--FMVMERLGIDLQKISGQNGTF 127 Query: 122 DHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVV--KADCTLKILDFGLA-------- 171 + L +ML ++++H +H D+K +N+++ K + + D+GL+ Sbjct: 128 KKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNGN 187 Query: 172 RTAGTTFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFP 224 + T + + + G+ + D+ +G M + G + + Sbjct: 188 HKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWE 240 >5DMZ-A nrPDB Length = 365 Score = 78.9 bits (193), Expect = 3e-15, Method: Composition-based stats. Identities = 49/283 (17%), Positives = 99/283 (34%), Gaps = 47/283 (16%) Query: 2 TTAQHQHYTVEVG----DTNFTIHSRYINLR-PIGSGAQGIVCAAY-----DTITQQNVA 51 + + ++ T F + S+ + + +G GA V A D +Q Sbjct: 40 SYPNTFEWQCKLPAIKPKTEFQLGSKLVYVHHLLGEGAFAQVYEATQGDLNDAKNKQKFV 99 Query: 52 IKKLSRPFQNVTHAKRAYREFKLMKLVN----HKNIIGLLNAFTPQRNLEEFQDVYLVME 107 +K Q + Y +LM+ + H + +A Q ++Y Sbjct: 100 LKV-----QKPANPWEFYIGTQLMERLKPSMQHMF-MKFYSAHLFQNGSVLVGELYSYGT 153 Query: 108 LMDA-NLCQ-VIQMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVV-------- 157 L++A NL + + + + +ML I+ +H IIH D+KP N ++ Sbjct: 154 LLNAINLYKNTPEKVMPQGLVISFAMRMLYMIEQVHDCEIIHGDIKPDNFILGNGFLEQD 213 Query: 158 ---KADCTLKILDFGLA---RTAGTTFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGC 211 L ++D G + + + T T ++ E++ + +D + V Sbjct: 214 DEDDLSAGLALIDLGQSIDMKLFPKGTIFTAKCETSGFQCVEMLSNKPWNYQIDYFGVAA 273 Query: 212 IMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTV 254 + M+ G + K+ + G P + R P + Sbjct: 274 TVYCMLFG-----------TYMKVKNEGGECKPEGLFRRLPHL 305 >4IX6-A nrPDB Length = 350 Score = 77.7 bits (190), Expect = 8e-15, Method: Composition-based stats. Identities = 62/344 (18%), Positives = 108/344 (31%), Gaps = 82/344 (23%) Query: 29 PIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYR-EFKLMKLVNHKN----I 83 P+GSG G V Q V L +V A+ E + V H N Sbjct: 27 PLGSGNFGTVFRGVFKGDQDVV----LKNAKADVMAAEELLECEMDVNYHV-HANAKGTC 81 Query: 84 IGLLNAFTPQRNLEEFQDVYLVME---LM----DANLCQVIQMDLDHDRMSYL------- 129 + + E LM N + + + + Sbjct: 82 ARFMGCIELGAKDGGEIYNGTLTEGLWLMWANEGENTVEALMRRGTAPLATAMACADATE 141 Query: 130 -------LYQMLCGIKHLHSAGIIHRDLKPSNIVV--KADCTLKILDFG---LARTAGTT 177 + ++L + LH G++HRD+KP+N++ K LK++D G L T Sbjct: 142 LGVTKKAMRELLGSLARLHECGVVHRDVKPANLIAAEKDGGVLKLIDLGAAALCLPLPET 201 Query: 178 FMMTPYVV---TRYYRAPEVILGMGYTENV-----------------DIWSVGCIMGEMI 217 P RY +A E+ L + D WS GC+M ++ Sbjct: 202 LNYYPGDGPADPRYAKADELYLLPPGSPRPTKDNAAKLWEAHKPDRFDSWSAGCVMLQLA 261 Query: 218 RGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGL 277 G+ ++++ + +G +F E Y F L +G Sbjct: 262 VVGL--RTDAGLERFLADYKAVGYDVNAFRG----------EKSGEYGTMDFAALDANGG 309 Query: 278 FPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEYIN 321 +L +++ + + R S + AL H + + Sbjct: 310 AGW--------------DLCQRLMEAERDARASCEAALSHAFFD 339 >4OAU-C nrPDB Length = 699 Score = 70.0 bits (170), Expect = 1e-12, Method: Composition-based stats. Identities = 32/172 (18%), Positives = 68/172 (39%), Gaps = 27/172 (15%) Query: 6 HQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHA 65 H+ Y +G F I +Y ++G + + +Q VA+K + Sbjct: 331 HRIYRPMIGKLKFFIDEKYKIADT----SEGGIYLGFY--EKQEVAVKTFCEG------S 378 Query: 66 KRAYREFKLMKLVN-HKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHD 124 RA RE ++ + +++ + + + +L ++ + L + L + + D Sbjct: 379 PRAQREVSCLQSSRENSHLVTFYGSESHRGHL------FVCVTLCEQTLEACLDVHRGED 432 Query: 125 -------RMSYLLYQMLCGIKHLH-SAGIIHRDLKPSNIVVKADCTLKILDF 168 +L + ++ LH S G H+DL+P NI++ + + DF Sbjct: 433 VENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADF 484 Score = 28.4 bits (62), Expect = 4.6, Method: Composition-based stats. Identities = 7/51 (13%), Positives = 18/51 (35%) Query: 273 FPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEYINVW 323 F D ++ + ++L+ ++ R + + L H + W Sbjct: 519 FEDLKAQSNEEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTW 569 >6G4J-A nrPDB Length = 315 Score = 69.3 bits (168), Expect = 3e-12, Method: Composition-based stats. Identities = 38/177 (21%), Positives = 62/177 (35%), Gaps = 26/177 (14%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNI 83 Y + +G GA GIV A + +VA+K + E ++K + Sbjct: 28 YTLRKQLGKGANGIVYLAE--TSDGHVALKV-------SDDSLSITSEVNVLKSFS---- 74 Query: 84 IGLLNAFTPQRNLEEFQDVYL----------VMELMDANLCQVIQMDLDHDRMSYLLYQM 133 + T + + D Y+ ME + L D + + L+ Q+ Sbjct: 75 --KAQSVTMGPSFFDTDDAYIPSANTKVSFYAMEYIKGPLLLKYVSDKGAEWIPVLMIQL 132 Query: 134 LCGIKHLHSAGIIHRDLKPSNIVVKA-DCTLKILDFGLARTAGTTFMMTPYVVTRYY 189 L + LH G I DLKP N++V ++ +D G G R Y Sbjct: 133 LSSLSVLHQQGWIFGDLKPDNLIVTGPPARIRCIDVGGTTKEGRAIKEYTEFYDRGY 189 >4O1O-A nrPDB Length = 717 Score = 68.9 bits (167), Expect = 4e-12, Method: Composition-based stats. Identities = 31/166 (18%), Positives = 62/166 (37%), Gaps = 16/166 (9%) Query: 6 HQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHA 65 H+ + +G I Y A+G + Q VA+K+ S + Sbjct: 334 HRIWRPMIGKLKIFIDEEYKIADT----AEGGIYLG--LYEDQEVAVKRFSEG------S 381 Query: 66 KRAYREFKLMKLVN-HKNIIGLLNAFTPQRNLEEFQDV--YLVMELMDANLCQVIQMDLD 122 R +E ++ + N++ + + L + Y + E + + + + D Sbjct: 382 TRGQQEVSCLQSSRANDNVVTFYGSESDGSCLHVCLALCEYTLQEHLANHRGDAVPNEED 441 Query: 123 HDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDF 168 +L + I LH +G H+DL+P NI++ + + DF Sbjct: 442 ES-ARNILSSLFKAIGELHRSGYSHQDLQPQNILIDSKNGTFLADF 486 >4CI6-B nrPDB Length = 643 Score = 66.2 bits (160), Expect = 2e-11, Method: Composition-based stats. Identities = 57/307 (18%), Positives = 103/307 (33%), Gaps = 65/307 (21%) Query: 44 TITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLV-----NHKNIIGLLN-AFTPQRNLE 97 Q+ VA K+ R + E + K + H N+ + A P N Sbjct: 66 KDKQRLVA--KIERSIAEG----HLFAELEAYKHIYKTAGKHPNLANVHGMAVVPYGNRY 119 Query: 98 EFQDVYLVMELMDA--------NLCQ-----VIQMDLDHDRMSYLLYQMLCGIKHLHSAG 144 L+M+ +D +L I + + ++ +++L HL AG Sbjct: 120 ---YYALLMDEVDGWRCSDTLRSLADSWKQGKINSEAYWGTIKFIAHRLLDVTNHLAKAG 176 Query: 145 IIHRDLKPSNIVVKA-DCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEV-ILGMGYTE 202 I+H D+KP N+V ++D GL +G P T ++APE+ + +G +E Sbjct: 177 IVHNDIKPGNVVFDRASGEPVVIDLGLHSRSGEQ----PKGFTESFKAPELGVGNLGASE 232 Query: 203 NVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENRP 262 D++ V + I G F I + P+ + P R + Sbjct: 233 KSDVFLVVSTLLHGIEG---FEKDPEIKPNQGLRFITSEPAHVMDENGYPIHRPGIAGVE 289 Query: 263 RYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEYINV 322 ++ +L + + R +EA HE+++ Sbjct: 290 TAYTR----------------------------FITDILGVSADSRPDSNEARLHEFLSD 321 Query: 323 WYDAEEV 329 EE Sbjct: 322 GTIDEES 328 >2JII-A nrPDB Length = 352 Score = 60.8 bits (146), Expect = 9e-10, Method: Composition-based stats. Identities = 36/226 (15%), Positives = 80/226 (35%), Gaps = 23/226 (10%) Query: 96 LEEFQDVYLVMELMDANLCQVI----QMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLK 151 + + + +LV+ + +L + + L + + ++L ++ LH +H ++ Sbjct: 127 VHQDKYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVT 186 Query: 152 PSNIVVK--ADCTLKILDFGLARTAGTTFMMTPYV--------VTRYYRAPEVILGMGYT 201 NI V + + +G A + YV + + ++ G G + Sbjct: 187 AENIFVDPEDQSQVTLAGYGFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMDLHKGCGPS 246 Query: 202 ENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENR 261 D+ S+G M + + G + + T+ + I++Q + P R Sbjct: 247 RRSDLQSLGYCMLKWLYGFLPW--TNCLPNTEDIMKQKQKFVDKPGPFVGPCGHWI---R 301 Query: 262 PRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLV--IDP 305 P T + ++ + R +A LL + V DP Sbjct: 302 PSETLQKYLKVVMALTYEEKPPYAMLRNNLEA--LLQDLRVSPYDP 345 >3ENH-A nrPDB Length = 540 Score = 58.9 bits (141), Expect = 3e-09, Method: Composition-based stats. Identities = 40/184 (21%), Positives = 74/184 (40%), Gaps = 27/184 (14%) Query: 8 HYTVEVGDTNFTI----HSRYINLRPIGSGAQGIVCAAYDTITQQNVAIK-KLSRPFQNV 62 +Y ++ + N+ R I IG GA+ + D+ +V IK ++ + +++ Sbjct: 318 NYRTDMVEVNWIKEIKGKKRKIPEHLIGKGAEADIK--RDSYLDFDVIIKERVKKGYRDE 375 Query: 63 T-----HAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANL-CQV 116 R RE + + LV P + + ++M ++ L V Sbjct: 376 RLDENIRKSRTAREARYLALVKD------FGIPAPYIFDVDLDNKRIMMSYINGKLAKDV 429 Query: 117 IQMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGT 176 I+ +LD + Y++ + LH +IH DL SN + D L I+DFGL + + Sbjct: 430 IEDNLD------IAYKIGEIVGKLHKNDVIHNDLTTSNFIFDKD--LYIIDFGLGKISNL 481 Query: 177 TFMM 180 Sbjct: 482 DEDK 485 >6BHC-A nrPDB Length = 438 Score = 58.9 bits (141), Expect = 4e-09, Method: Composition-based stats. Identities = 54/316 (17%), Positives = 96/316 (30%), Gaps = 90/316 (28%) Query: 41 AYDTITQQNVAIKKLSRPFQNVTH-------AKRAYREFKLMKLVNH-----KNIIGLLN 88 A D + A+K + + F + + H N LL Sbjct: 79 AKDPLNN--YAVKICKSKAKESQQYYHSLAVRQSLAVHFNIQQDCGHFLAEVPN--RLLP 134 Query: 89 AFTPQRN-------LEEFQDVYLVMELMDANLCQVIQM-DLDHDRMSYLLYQMLCGIKHL 140 P + + V + + +L Q + DL ++ LL Q+ G++HL Sbjct: 135 WEDPSKKQRSHVVVITREVPCLTVADFVRDSLAQHGKSPDLYERQVCLLLLQLCSGLEHL 194 Query: 141 HSAGIIHRDLKPSNIVVKA---DCTLKILDFGLARTAGTTFMMTPYVVTRYY-------- 189 + H DL+ N+++ T + FG A T+ T +V+ + Sbjct: 195 KPYHVTHCDLRLENLLLVHYQPGGTAQ--GFGPAEPTPTSSYPTRLIVSNFSQAKQKSHL 252 Query: 190 -----------RAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQ 238 APE+I Y + D + G ++ EM+ F Sbjct: 253 VDPEILRDQSRLAPEIITATQY-KKCDEFQTGILIYEMLHLPNPF--------------- 296 Query: 239 LGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLS 298 P ++ R F + GL + L S Sbjct: 297 ----------DENPELKEREYTRADLPRIPFRSPYSRGL----------------QQLAS 330 Query: 299 KMLVIDPEQRISVDEA 314 +L +P +RI + +A Sbjct: 331 CLLNPNPSERILISDA 346 >6M7Z-A nrPDB Length = 319 Score = 58.5 bits (140), Expect = 4e-09, Method: Composition-based stats. Identities = 38/203 (18%), Positives = 83/203 (40%), Gaps = 26/203 (12%) Query: 103 YLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCT 162 Y+ L + +++ H + L M+ +K LH+ G++HR ++ ++ V D T Sbjct: 123 YIFHPLSKGLVGDMLETGRSHPDVQVLAANMVAALKSLHNLGLLHRSIELNSFSVLPDGT 182 Query: 163 LKILDFGLARTAGT-TFMMTPYVVTRYYRAPEV---------ILGMGYTENVDIWSVGCI 212 + + A GT T + + APE+ + +T D++S+G Sbjct: 183 VVLGGLDTAAPIGTETRLWVGFFGQE--TAPEIDRNFLADLALTQGRHTVKSDVYSLGVA 240 Query: 213 ---MGEMIRGGVLFPGT------DHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENRPR 263 + +++ G L P DH++ +K+ +++ P ++ +++ P Sbjct: 241 FRNLVQLLGNGNLGPEDRGAVRQDHLELLDKLSQKMIEEEPGNRPTIEEIMKD-----PL 295 Query: 264 YTGYSFDRLFPDGLFPNDNNQNS 286 + G +F+ + P QN Sbjct: 296 FEGLNFEDIEEGKARPFRYKQNR 318 >4AZW-A nrPDB Length = 471 Score = 58.5 bits (140), Expect = 5e-09, Method: Composition-based stats. Identities = 24/131 (18%), Positives = 48/131 (36%), Gaps = 13/131 (9%) Query: 47 QQNVAIKK--------LSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEE 98 ++ K + ++ + + E K + +A + E Sbjct: 259 GEDYVCKFFYYDMPHGILTAEESQRNKHELHNEIKFLTQPP-----AGFDAPAVLAHGEN 313 Query: 99 FQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK 158 Q +LVME + L + + +L +L + L G H D++P N++V Sbjct: 314 AQSGWLVMEKLPGRLLSDMLAAGEEIDREKILGSLLRSLAALEKKGFWHDDVRPWNVMVD 373 Query: 159 ADCTLKILDFG 169 A +++DFG Sbjct: 374 ARQHARLIDFG 384 >4AZV-A nrPDB Length = 569 Score = 58.5 bits (140), Expect = 5e-09, Method: Composition-based stats. Identities = 21/83 (25%), Positives = 37/83 (44%) Query: 87 LNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGIKHLHSAGII 146 +A + E Q +LVME + L + + +L +L + L G Sbjct: 302 FDAPAVLAHGENAQSGWLVMEKLPGRLLSDMLAAGEEIDREKILGSLLRSLAALEKQGFW 361 Query: 147 HRDLKPSNIVVKADCTLKILDFG 169 H D++P N++V A +++DFG Sbjct: 362 HDDVRPWNVMVDARQHARLIDFG 384 >6EAS-A nrPDB Length = 308 Score = 55.8 bits (133), Expect = 3e-08, Method: Composition-based stats. Identities = 38/263 (14%), Positives = 74/263 (28%), Gaps = 56/263 (21%) Query: 61 NVTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELM-DANLCQVIQ- 118 + + + ++ + V+HKN + LL + +V E + L + + Sbjct: 81 SKENESQYRKKITNLSKVSHKNFMNLLGYCEEEHPFTRV----MVFEYAPNGTLFEHLHV 136 Query: 119 ---MDLDHDRMSYLLYQMLCGIKHLHSAGI--IHRDLKPSNIVVKADCTLKILDFGLART 173 LD + + ++H+H R+ + + + D K+ D Sbjct: 137 REAEKLDWMARLRISMGIAYCLEHMHQLQTPAALRNFDSTTVYLTDDFAAKVSDL---EF 193 Query: 174 AGTTFMMTPYVVTRYYRAP--EVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQ 231 +P E I+ G ++ E++ G V D Sbjct: 194 WNDAKGHNSTTNNELAFSPDMEDIVRK----------YGMVLLEILTGRVPSSEDDGP-- 241 Query: 232 WNKIIEQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKAS 291 L+ V Y E R + G FP D + Sbjct: 242 ------------------LENWVSRYFEGGMRLEELIDPSI---GFFPEDTARALCEVVR 280 Query: 292 DARNLLSKMLVIDPEQRISVDEA 314 + DP++R + E Sbjct: 281 SCID-------RDPKKRPQMKEV 296 >5GZA-A nrPDB Length = 290 Score = 55.4 bits (132), Expect = 4e-08, Method: Composition-based stats. Identities = 39/209 (18%), Positives = 69/209 (33%), Gaps = 36/209 (17%) Query: 26 NLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIG 85 ++ IG GA V + Q VA+ LS + +A +++ + +++ Sbjct: 29 RVKLIGQGAVKKVYLSEWQ--GQKVALSVLS----SDQYADDFLHGLSMLRALQSSHVVT 82 Query: 86 LLNAFTPQRNL-EEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGIKHLHS-- 142 L+ E+ + V+ L + + L + + +LHS Sbjct: 83 LVGVCEEDAVFVTEYHPLGSVLTLDTTLAQERYRWRNSWHTRLQLAIDYVAFLAYLHSSP 142 Query: 143 AGI--------IHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVV----TRYYR 190 AGI +H+ L S ++ +D L D A + T + Sbjct: 143 AGIRVMCDSNDLHKTL--SQFLLASDMRLLANDLD-ALPEVEKGGLGVKCGHHELTGDFV 199 Query: 191 APEVI------------LGMGYTENVDIW 207 APE + GY E DIW Sbjct: 200 APEQLWPYGEDFSFSDEAMPGYDEKTDIW 228 >6EWX-A nrPDB Length = 484 Score = 54.2 bits (129), Expect = 8e-08, Method: Composition-based stats. Identities = 38/241 (15%), Positives = 69/241 (28%), Gaps = 83/241 (34%) Query: 115 QVIQMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCT------------ 162 + ++ R+ +LL Q+ G++HL GIIHRDL N+++ Sbjct: 201 HRAEPEVYERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLVHCNPQSSPGPSANPSV 260 Query: 163 -----------------------------LKILDFGLARTAGTTFMMTPYVVTRYYRAPE 193 L I +F A+ ++ APE Sbjct: 261 PTTTSRCPSAAPAATTACQGGPGEKHLPRLIISNFLKAKQKPGGTTNLQQKKSQARLAPE 320 Query: 194 VILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPT 253 ++ Y D + G ++ E++ F ++ Sbjct: 321 IVSASQY-RKFDEFQTGILIYELLHQPNPF-------------------------EVRAQ 354 Query: 254 VRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDE 313 +R R L+ + + L +L DP +RI + E Sbjct: 355 LRERDYRREDLPPLPTLSLY----------------SPGLQQLAHLLLEADPIKRIRIGE 398 Query: 314 A 314 A Sbjct: 399 A 399 >5GZ9-A nrPDB Length = 305 Score = 53.5 bits (127), Expect = 2e-07, Method: Composition-based stats. Identities = 34/207 (16%), Positives = 70/207 (33%), Gaps = 31/207 (14%) Query: 26 NLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIG 85 L+ +G GA V + VA+ +L+R + + +++K + ++++ Sbjct: 38 QLKRVGEGAVKRVFLSEWKE--HKVALSRLTR----LEMKEDFLHGLQMLKSLQSEHVVT 91 Query: 86 LLNAFTPQRN-LEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGIKHLHSAG 144 L+ L E+ + + L + Q L + + I +LH + Sbjct: 92 LVGYCEEDGTILTEYHPLGSLSNLEETLQLSKYQDVNTWQHRLQLAMEYVSIINYLHHSP 151 Query: 145 IIHRDLKPSN--------IVVKADCTLKILDFGLARTAGTTFMMTPYVVTRY----YRAP 192 + R + SN ++ ++ ++ D + R + AP Sbjct: 152 LGTRVMCDSNDLPKTLSQYLLTSNFSIVANDLDALPLVDHDSGVLIKCGHRELHGDFVAP 211 Query: 193 EVI------------LGMGYTENVDIW 207 E + L Y E VDIW Sbjct: 212 EQLWPYGEDTPFQDDLMPSYNEKVDIW 238 >4CYJ-A nrPDB Length = 438 Score = 50.4 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 29/170 (17%), Positives = 64/170 (37%), Gaps = 29/170 (17%) Query: 38 VCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLE 97 V A ++ ++ A+++L +T+ K K K + + +I+ + FT + Sbjct: 71 VYKAQNSRNGRHYALRRLEGYR--LTNEKAILNVMKDWKKIKNASIVTIHEVFTTR---- 124 Query: 98 EFQDVYLVMELMDANLCQVIQMD---------------LDHDRMSYLLYQMLCGIKHLHS 142 EF D L+ L + +Q + + + + Q+ +K +HS Sbjct: 125 EFGDSSLIFAYDFHPLSKTLQEHHFQPIHGNRYRPPPAVPENTIWGYICQIANALKTIHS 184 Query: 143 AGIIHRDLKPSNIVVKADCTLKIL--------DFGLARTAGTTFMMTPYV 184 + R L+PS I++ +++ FG+ + +V Sbjct: 185 NRLAARCLEPSKIILTDINRIRLSACAILDVVQFGMNSRSVVELQQEDFV 234 >6G38-A nrPDB Length = 357 Score = 50.0 bits (118), Expect = 2e-06, Method: Composition-based stats. Identities = 31/206 (15%), Positives = 59/206 (28%), Gaps = 63/206 (30%) Query: 11 VEVGDTNFTIHS-------------------RYINLRPIGSGAQGIVCAAYDTITQQNVA 51 V++G N S + IG G G V VA Sbjct: 11 VDLGTENLYFQSMGECSQKGPVPFSHCLPTEKLQRCEKIGEGVFGEVFQTI--ADHTPVA 68 Query: 52 IKKL------------SRPFQNVTHAKRAYREFKLMK-----------LVNHKNIIG--- 85 IK + + F+ + +E L+ +N + + Sbjct: 69 IKIIAIEGPDLVNGSHQKTFEEILPEIIISKELSLLSGEVCNRTEGFIGLNSVHCVQGSY 128 Query: 86 ---LLNAFT----------PQRNLEEFQDVYLVMEL-MDANLCQVIQMDLDH-DRMSYLL 130 LL A+ + + + +++V+E + ++ L +L Sbjct: 129 PPLLLKAWDHYNSTKGSANDRPDFFKDDQLFIVLEFEFGGIDLEQMRTKLSSLATAKSIL 188 Query: 131 YQMLCGIKHLH-SAGIIHRDLKPSNI 155 +Q+ + S HRDL N+ Sbjct: 189 HQLTASLAVAEASLRFEHRDLHWGNV 214 >5VE6-A nrPDB Length = 492 Score = 48.8 bits (115), Expect = 3e-06, Method: Composition-based stats. Identities = 15/35 (42%), Positives = 23/35 (65%) Query: 123 HDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVV 157 R+ +LL Q+ G++HL GIIHRDL N+++ Sbjct: 207 ERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLL 241 Score = 32.7 bits (73), Expect = 0.29, Method: Composition-based stats. Identities = 20/125 (16%), Positives = 36/125 (28%), Gaps = 42/125 (33%) Query: 190 RAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQR 249 APE++ Y D + G ++ E++ P+P ++ Sbjct: 325 LAPEIVSASQY-RKFDEFQTGILIYELL----------------------HQPNPFEVRA 361 Query: 250 LQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRI 309 E+ P S + + L +L DP +RI Sbjct: 362 QLRERDYRQEDLPPLPALSL-------------------YSPGLQQLAHLLLEADPIKRI 402 Query: 310 SVDEA 314 + EA Sbjct: 403 RIGEA 407 >3Q60-A nrPDB Length = 371 Score = 48.5 bits (114), Expect = 5e-06, Method: Composition-based stats. Identities = 49/335 (14%), Positives = 106/335 (31%), Gaps = 68/335 (20%) Query: 23 RYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREF-----KLMKL 77 + + P+ G + +V D ++ A+K + +N E +L+ Sbjct: 63 KLKLVEPLRVGDRSVVFLVRDVERLEDFALKVFTMGAENSRSELERLHEATFAAARLLGE 122 Query: 78 V-----NHKNIIGLLNAF-----------TPQRNLEEFQDVYLVM-------ELMDANLC 114 + + ++ +A +P ++ + L+M EL+ + L Sbjct: 123 SPEEARDRRRLLLPSDAVAVQSQPPFAQLSPGQDDYAVANYLLLMPAASVDLELLFSTLD 182 Query: 115 QVIQMDLDHDRMSY--LLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLAR 172 V D ++ L Q++ +L S G++H P N+ + D L + D ++ Sbjct: 183 FVYVFRGDEGILALHILTAQLIRLAANLQSKGLVHGHFTPDNLFIMPDGRLMLGD--VSA 240 Query: 173 TAGTTFMMTPYVVTRYYRAPEVILGM--GYTENVDIWSVGCIMGEMIRGGVLFPGTDHID 230 V Y E + +T ++ W +G + + + F Sbjct: 241 LWKVGTRGPASSVPVTYAPREFLNASTATFTHALNAWQLGLSIYRVWCLFLPF------- 293 Query: 231 QWNKIIEQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKA 290 L TP ++ + + P +F P F Sbjct: 294 -------GLVTPG------IKGSWKRPSLRVPGTDSLAFGSCTPLPDF------------ 328 Query: 291 SDARNLLSKMLVIDPEQRISVDEALKHEYINVWYD 325 + L+ + L D +R+ EA++ + Sbjct: 329 --VKTLIGRFLNFDRRRRLLPLEAMETPEFLQLQN 361 >3BYV-A nrPDB Length = 377 Score = 47.7 bits (112), Expect = 8e-06, Method: Composition-based stats. Identities = 27/155 (17%), Positives = 51/155 (32%), Gaps = 14/155 (9%) Query: 118 QMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTT 177 L H L Q++ + LH G++H L+P +IV+ + + F Sbjct: 200 HKSLVHHARLQLTLQVIRLLASLHHYGLVHTYLRPVDIVLDQRGGVFLTGF---EHLVRD 256 Query: 178 FMMTPYVVTRYYRAPEVILGM---GY--------TENVDIWSVGCIMGEMIRGGVLFPGT 226 V+R + PE+ Y T + D W++G ++ + + Sbjct: 257 GARVVSSVSRGFEPPELEARRATISYHRDRRTLMTFSFDAWALGLVIYWIWCADLPITKD 316 Query: 227 DHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENR 261 + I L+ +R E+R Sbjct: 317 AALGGSEWIFRSCKNIPQPVRALLEGFLRYPKEDR 351 >4WWA-A nrPDB Length = 261 Score = 47.7 bits (112), Expect = 9e-06, Method: Composition-based stats. Identities = 39/176 (22%), Positives = 65/176 (36%), Gaps = 37/176 (21%) Query: 25 INLRPIGSGAQGIV-------CAAYDTITQQNVAIKKLSRPFQNVTHAK--------RAY 69 +++ PI GA+ IV + Q IK RP + H + R Sbjct: 17 VDIAPISQGAEAIVFTTTTHPYLPRAKDSHQKYIIKY--RPPKRYRHPQIDQALTKHRTL 74 Query: 70 REFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANL------------CQVI 117 E +L+ + +I PQ + + ++ +E + +L + Sbjct: 75 NESRLLAKL---YLIP--GLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMH 129 Query: 118 QMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADC---TLKILDFGL 170 D D ++ L ++ I LH H DL SNIV+ D T ++DFGL Sbjct: 130 DQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGL 185 >4BWP-A nrPDB Length = 448 Score = 44.6 bits (104), Expect = 7e-05, Method: Composition-based stats. Identities = 26/167 (15%), Positives = 50/167 (29%), Gaps = 43/167 (25%) Query: 39 CAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEE 98 A T L R + + ++ K + H N++ L FT + + Sbjct: 67 YRATHNTTGYKY---CLRRIHGFRLQSTKCMTLVEMWKKLQHTNVVQLREVFTTKAFGD- 122 Query: 99 FQDVYLVMELMDAN---LCQVIQMD-------------------------------LDHD 124 + LV + + L + L Sbjct: 123 -NSLVLVYDYHPGSQTLLAKYFTPAPETNGYTDPFQGEARPFSHKSNMQRTSNGPLLPEA 181 Query: 125 RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKAD----CTLKILD 167 + ++ Q+ G+K +H AG+ + L P+ I+V + I D Sbjct: 182 TIWSIIMQLTAGLKAIHHAGLACKVLDPTKIIVTGKRVRFSSCCISD 228 >6R5K-O nrPDB Length = 689 Score = 44.2 bits (103), Expect = 8e-05, Method: Composition-based stats. Identities = 18/137 (13%), Positives = 49/137 (35%), Gaps = 12/137 (8%) Query: 39 CAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEE 98 + + +K+L + + + +++ +N N+I + F + + Sbjct: 311 FKVFSNYDGKAYVLKRLPN-IDKSMNPNKISKIYQIWSKINCTNLIKFRDIFQTTKFGDL 369 Query: 99 FQDVYLVMELMDANLC-------QVIQMDLDHDRMSYLLYQMLCGIKHLHSAGI-IHRDL 150 + LV + +L + + ++ + L Q+ I +HS + I L Sbjct: 370 --SICLVFDYYPNSLSLYDYHFVNFPKFPITNNYLWIYLVQLTNVINSIHSQNLSIGNTL 427 Query: 151 KPSNIVVKAD-CTLKIL 166 +++ D +K+ Sbjct: 428 NWRKVLITGDPGRIKLS 444 >2W1Z-A nrPDB Length = 368 Score = 43.8 bits (102), Expect = 1e-04, Method: Composition-based stats. Identities = 46/270 (17%), Positives = 83/270 (30%), Gaps = 45/270 (16%) Query: 33 GAQGIVCAAYDTITQQ--NV------------AIKKLS---------RPFQNVTHAKRAY 69 G+ I A D T + V AIK+LS R +N AK Sbjct: 70 GSY-ICLEATDQETGEPLEVHVPYFTERPPSNAIKQLSEQVLRLRLLRGIKNQRQAKAYL 128 Query: 70 REFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLV--MELMDANLCQVI------QMDL 121 R + LV ++ +R++ +L M+ L V+ L Sbjct: 129 RFIFPIDLVKDPKKRKMIRVRLDERDMWVLSRFFLYPRMQSNLHILGDVLLSHSSTHKSL 188 Query: 122 DHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMT 181 H L Q++ L G++H D + NI++ + + G Sbjct: 189 VHHARLQLTLQLIRLAASLQHYGLVHADFQVRNILLDQRGGVFLT--GFEHLVRDGASAV 246 Query: 182 PYVVTRYYRAPE-----VILGMGY-----TENVDIWSVGCIMGEMIRGGVLFPGTDHIDQ 231 + R + PE ++ + T D W++G + + + + Sbjct: 247 SPIG-RGFAPPETTAERMLPYRQHHPTLMTFPFDTWTLGLAIYWIWCADLPNTEDAELGG 305 Query: 232 WNKIIEQLGTPSPSFMQRLQPTVRNYVENR 261 I + L+ +R E+R Sbjct: 306 IEWIYRRCKNIPQPVRALLEGFLRYSKEDR 335 >4XR7-L nrPDB Length = 465 Score = 43.1 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 18/137 (13%), Positives = 49/137 (35%), Gaps = 12/137 (8%) Query: 39 CAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEE 98 + + +K+L + + + +++ +N N+I + F + + Sbjct: 87 FKVFSNYDGKAYVLKRLPN-IDKSMNPNKISKIYQIWSKINCTNLIKFRDIFQTTKFGDL 145 Query: 99 FQDVYLVMELMDANLC-------QVIQMDLDHDRMSYLLYQMLCGIKHLHSAGI-IHRDL 150 + LV + +L + + ++ + L Q+ I +HS + I L Sbjct: 146 --SICLVFDYYPNSLSLYDYHFVNFPKFPITNNYLWIYLVQLTNVINSIHSQNLSIGNTL 203 Query: 151 KPSNIVVKAD-CTLKIL 166 +++ D +K+ Sbjct: 204 NWRKVLITGDPGRIKLS 220 >3DZO-A nrPDB Length = 413 Score = 42.3 bits (98), Expect = 4e-04, Method: Composition-based stats. Identities = 26/154 (16%), Positives = 49/154 (31%), Gaps = 13/154 (8%) Query: 118 QMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTT 177 L H L Q++ + LH G++H L+P +IV+ + + G Sbjct: 205 HKSLVHHARLQLTLQVIRLLASLHHYGLVHTYLRPVDIVLDQRGGVFLT--GFEHLVRDG 262 Query: 178 FMMTPYVVTRYYRAPE------VILGMGY----TENVDIWSVGCIMGEMIRGGVLFPGTD 227 + R + PE + G + T D W++G + + + Sbjct: 263 ASAVSPIG-RGFAPPETTAERMLPFGQHHPTLMTFAFDTWTLGLAIYWIWCADLPNTDDA 321 Query: 228 HIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENR 261 + I L+ +R E+R Sbjct: 322 ALGGSEWIFRSCKNIPQPVRALLEGFLRYPKEDR 355 >1TQM-A nrPDB Length = 282 Score = 41.1 bits (95), Expect = 7e-04, Method: Composition-based stats. Identities = 28/148 (18%), Positives = 57/148 (38%), Gaps = 23/148 (15%) Query: 35 QGIVCAAYDTITQQNVAIKKLSRPFQ------NVTHAKRAYREFKLMKLVNHKNIIGLLN 88 G + + + KK+ +V + A EF+ ++ + Sbjct: 114 FGECVVKFHKVGHTSF--KKVKEKRDYGDLHFSVLAIRSARNEFRALQKLQ--------G 163 Query: 89 AFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGIKHLHSAGIIHR 148 P+ E V +MEL+DA ++++ + + +L ++ H GI+H Sbjct: 164 LAVPKVYAWEGNAV--LMELIDAKELYRVRVENPDEVLDMILEEVAK---FYH-RGIVHG 217 Query: 149 DLKPSNIVVKADCTLKILDFGLARTAGT 176 DL N++V + + I+DF + G Sbjct: 218 DLSQYNVLVSEEG-IWIIDFPQSVEVGE 244 >6G18-v nrPDB Length = 552 Score = 38.4 bits (88), Expect = 0.005, Method: Composition-based stats. Identities = 22/102 (21%), Positives = 42/102 (41%), Gaps = 13/102 (12%) Query: 68 AYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDA-NLCQVIQMDLDHDRM 126 A +EF MK L P ++ +VMEL++ LCQ+ ++ Sbjct: 158 AMKEFAYMK--------ALYERKFPVPKPIDYNRHAVVMELINGYPLCQIHHVEDPASVY 209 Query: 127 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDF 168 + ++ L + G+IH D N+++ + ++DF Sbjct: 210 DEAMELIVK----LANHGLIHGDFNEFNLILDESDHITMIDF 247 >6FAI-l nrPDB Length = 425 Score = 37.7 bits (86), Expect = 0.008, Method: Composition-based stats. Identities = 34/172 (19%), Positives = 62/172 (36%), Gaps = 39/172 (22%) Query: 24 YINLRPIGSGAQGIVCAAYDTITQQNVAIKK-----------------LSRPFQNVT--- 63 Y IG G + + D V +K L + Q Sbjct: 95 YSVGNTIGVGKESDIYKVSDKNGNPRV-MKIHRLGRTSFHSVRNNRDYLKKSNQGANWMH 153 Query: 64 -HAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLD 122 A +E++ M ++ K F + + + +VMEL++ + ++ Sbjct: 154 LSRLAANKEYQFMSMLYSK-------GFKVPEPFDNSRHI-VVMELIEGYPMRRLRK--- 202 Query: 123 HDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKA------DCTLKILDF 168 H + L ++C I L ++G+IH D NI++K DC ++DF Sbjct: 203 HKNIPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDF 254 >5YK0-A nrPDB Length = 452 Score = 37.7 bits (86), Expect = 0.009, Method: Composition-based stats. Identities = 25/177 (14%), Positives = 50/177 (28%), Gaps = 54/177 (30%) Query: 36 GIVCAAYDTITQQNVAIKKLSRPFQNV--THAKRAYREFKLMKLV--------------- 78 G V A + VA+K K R ++K + Sbjct: 146 GQVHKAIW-SDGREVAVKIQYPGADEALRADLKTMQRMVGVLKQLSPGADVQGVVDELVE 204 Query: 79 -----------------------NHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDA-NLC 114 +H ++ ++ E ++ + Sbjct: 205 RTEMELDYRLEAANQRAFAKAYHDHPR--------FQVPHVVASAPKVVIQEWIEGVPMA 256 Query: 115 QVIQMDLDHDR--MSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFG 169 ++I+ R + LL ++ G++H D P N ++ D + I+DFG Sbjct: 257 EIIRHGTTEQRDLIGTLLAELT--FDAPRRLGLMHGDAHPGNFMLLPDGRMGIIDFG 311 >4BVU-A nrPDB Length = 211 Score = 37.3 bits (85), Expect = 0.010, Method: Composition-based stats. Identities = 35/171 (20%), Positives = 61/171 (35%), Gaps = 21/171 (12%) Query: 2 TTAQHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQN 61 +T + E +++ I + I + IG G+ + + + A+ ++ Sbjct: 20 STIIQTPFPFENNNSHAGIVTEPILGKLIGQGSTAEIFEDVNDSS----AL------YKK 69 Query: 62 VTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQR---NLEEFQDVYLVMELMDANLCQVIQ 118 Y E M + L NAF ++ DVYL M + I Sbjct: 70 YDLIGNQYNEILEMAWQESE----LFNAFYGDEASVVIQYGGDVYLRMLRVPGTPLSDID 125 Query: 119 MDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCT-LKILDF 168 D + L Q++C + L IIH DL N++ + L +DF Sbjct: 126 TADIPDNIESLYLQLICKLNEL---SIIHYDLNTGNMLYDKESESLFPIDF 173 >6FDN-A nrPDB Length = 320 Score = 37.3 bits (85), Expect = 0.011, Method: Composition-based stats. Identities = 22/102 (21%), Positives = 42/102 (41%), Gaps = 13/102 (12%) Query: 68 AYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDA-NLCQVIQMDLDHDRM 126 A +EF MK L P ++ +VMEL++ LCQ+ ++ Sbjct: 158 AMKEFAYMK--------ALYERKFPVPKPIDYNRHAVVMELINGYPLCQIHHVEDPASVY 209 Query: 127 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDF 168 + ++ L + G+IH D N+++ + ++DF Sbjct: 210 DEAMELIVK----LANHGLIHGDFNEFNLILDESDHITMIDF 247 >4CZY-B nrPDB Length = 429 Score = 35.7 bits (81), Expect = 0.032, Method: Composition-based stats. Identities = 36/272 (13%), Positives = 85/272 (31%), Gaps = 40/272 (14%) Query: 39 CAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEE 98 A + ++ A++++ +T+ K K K + + NI+ + AFT + Sbjct: 61 YKAQNNKNGRHFALRRIEGYR--LTNEKAILNVTKEWKKIINANIVTVHEAFTTE--FFG 116 Query: 99 FQDVYLVMEL--MDANLCQVIQM------------DLDHDRMSYLLYQMLCGIKHLHSAG 144 + V + + L + + + + Q+ + +H+A Sbjct: 117 DSSLIFVYDFHPLSETLYDHHFPPNNSHNRLRNTNKIPENLLWSYVCQIANALLAIHNAK 176 Query: 145 IIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGYTENV 204 + R L+ S I + + +++ +P T E + + + Sbjct: 177 LAARCLELSKI-IWENNRIRLA---ACSILDVLHHDSPNRKTI-----EELQQEDFVK-- 225 Query: 205 DIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENRPRY 264 G I+ + +N I L T P + +L+ + ++ Sbjct: 226 ----FGRIILALATNTP-------TLNFNNIDAALATIVPRYSTQLRGVLEWLIKPSAPG 274 Query: 265 TGYSFDRLFPDGLFPNDNNQNSRRKASDARNL 296 + + L N N + SD + Sbjct: 275 ETKTVETLLGGITTHLANFANFVMQESDEKEF 306 >4ESA-B nrPDB Length = 146 Score = 34.2 bits (77), Expect = 0.094, Method: Composition-based stats. Identities = 15/50 (30%), Positives = 22/50 (44%), Gaps = 6/50 (12%) Query: 33 GAQGIVCAAYDTITQQNVA---IKK---LSRPFQNVTHAKRAYREFKLMK 76 G+ G + A I Q VA IK L R +N+ + K Y E ++ Sbjct: 43 GSFGNLYNAEAIIGNQKVAAHGIKVLHGLDRAVKNMDNIKEIYAELSILH 92 >6EF6-A nrPDB Length = 354 Score = 34.2 bits (77), Expect = 0.10, Method: Composition-based stats. Identities = 13/76 (17%), Positives = 27/76 (35%), Gaps = 14/76 (18%) Query: 107 ELMDANLCQVIQMDLDHDRMSYLLYQMLCGIKHLHSA-----------GIIHRDLKPSNI 155 E + + + + + LH G+IH DL+ +N+ Sbjct: 178 EHCLGDTPRWGRWQDAEGVGASETALLTRAQDLLHRKLEEYGSGPDRYGLIHADLRLANL 237 Query: 156 VVKADC---TLKILDF 168 +V + T+ ++DF Sbjct: 238 LVDSSTPQRTITVIDF 253 >6CCZ-A nrPDB Length = 455 Score = 33.8 bits (76), Expect = 0.11, Method: Composition-based stats. Identities = 20/132 (15%), Positives = 41/132 (31%), Gaps = 4/132 (3%) Query: 167 DFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMG----EMIRGGVL 222 D+GL+ + R +R+ E+I +T + +VG + E + G Sbjct: 6 DYGLSEADPDVHAIINKEKDRQFRSLELIASENFTSKAVMEAVGSCLTNKYSEGLPGKRY 65 Query: 223 FPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDN 282 + G +HID+ + +Q + + P L P + Sbjct: 66 YGGNEHIDELEILCQQRALAAFHLDGDKWGVNVQPLSGSPANFAVYTAILKPHDRIMGLD 125 Query: 283 NQNSRRKASDAR 294 + + Sbjct: 126 LPHGGHLSHGFM 137 >6DFL-A nrPDB Length = 259 Score = 32.7 bits (73), Expect = 0.24, Method: Composition-based stats. Identities = 18/130 (13%), Positives = 47/130 (36%), Gaps = 8/130 (6%) Query: 68 AYREFKLMKLVNHKNIIGLLNA-FTPQRNLEEFQDVYLVMELMDANLC------QVIQMD 120 A +E++ ++ ++ + + + + + Q ++V E + + + Sbjct: 75 ARQEWQAIRRLHEAGVATMTAVAYGERGSDPARQHSFIVTEELAPTVDLEVFSQDWRERP 134 Query: 121 LDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMM 180 L+ + + +H AG+ HRD + ++ D + DF L+ Sbjct: 135 PPPRLKRALVEAVARMVGDMHRAGVNHRDCYICHFLLHTDKPVSADDFRLS-VIDLHRAQ 193 Query: 181 TPYVVTRYYR 190 T + +R Sbjct: 194 TRDATPKRWR 203 >3URH-A nrPDB Length = 491 Score = 32.7 bits (73), Expect = 0.28, Method: Composition-based stats. Identities = 15/44 (34%), Positives = 19/44 (43%), Gaps = 3/44 (6%) Query: 11 VEVGDTNFTIHSR--YINLRPIGSGAQGIVCAAYDTITQQNVAI 52 V++G N S Y + IGSG G VCA VA+ Sbjct: 11 VDLGTENLYFQSMMAYDLI-VIGSGPGGYVCAIKAAQLGMKVAV 53 >5JNE-A nrPDB Length = 367 Score = 31.9 bits (71), Expect = 0.41, Method: Composition-based stats. Identities = 16/97 (16%), Positives = 33/97 (34%), Gaps = 15/97 (15%) Query: 76 KLVNHKNIIGLLNAFTPQRNLEEFQDVYL-----VMELMDANLCQVIQMDLDHDRMSYLL 130 K++ H II ++ L E +++ L +M L + +M ++ Sbjct: 158 KVLQHPKIIKQATLLYLKKTLREDEEMGLTTTSTIMSL--QDPISYTRMKYPSKSINCKH 215 Query: 131 YQMLCGIKHLHSA--------GIIHRDLKPSNIVVKA 159 Q + LHS + D+ N+ + Sbjct: 216 LQCFDALWFLHSQLQIPTWQCPVCQIDIALENLAISE 252 >4FDJ-A nrPDB Length = 502 Score = 31.1 bits (69), Expect = 0.79, Method: Composition-based stats. Identities = 23/147 (15%), Positives = 41/147 (27%), Gaps = 27/147 (18%) Query: 192 PEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQ 251 PE++ GY + + G ++ E G+P+ F Sbjct: 99 PELLKKAGYVSKI------VGKWHL--GHRP-QFHPLKHGFD---EWFGSPNCHFGPYDN 146 Query: 252 PTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISV 311 N R + FP L + N +A + + + Sbjct: 147 KARPNIPVYRDWEMVGRYYEEFPINLKTGEANLTQIYL-QEALDFIKR------------ 193 Query: 312 DEALKHEYINVWY-DAEEVDAPAPEPY 337 +A H + W DA A +P+ Sbjct: 194 -QARHHPFFLYWAVDATHAPVYASKPF 219 >3I2D-A nrPDB Length = 371 Score = 31.1 bits (69), Expect = 0.87, Method: Composition-based stats. Identities = 16/97 (16%), Positives = 32/97 (32%), Gaps = 15/97 (15%) Query: 76 KLVNHKNIIGLLNAFTPQRNLEEFQDVYL-----VMELMDANLCQVIQMDLDHDRMSYLL 130 K++ H II ++ L E +++ L +M L +M ++ Sbjct: 213 KVLQHPKIIKQATLLYLKKTLREDEEMGLTTTSTIMSL--QCPISYTRMKYPSKSINCKH 270 Query: 131 YQMLCGIKHLHSA--------GIIHRDLKPSNIVVKA 159 Q + LHS + D+ N+ + Sbjct: 271 LQCFDALWFLHSQLQIPTWQCPVCQIDIALENLAISE 307 >2QG7-A nrPDB Length = 458 Score = 30.0 bits (66), Expect = 1.6, Method: Composition-based stats. Identities = 35/158 (22%), Positives = 57/158 (36%), Gaps = 42/158 (26%) Query: 45 ITQQNVAIKKLSRPFQ--------NVTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNL 96 IT + +K +S+ + RE K+ ++ +KNI + F + Sbjct: 120 ITNILIKVKDMSKQAKYLIRLYGPKTDEIINREREKKISCILYNKNIAKKIYVFFTNGRI 179 Query: 97 EEFQDVY-LVME---------LMDANLCQVIQMDLDHDRMSYL-LYQMLCGI-------- 137 EEF D Y L E L+ NL + + L+ + L + Q + G Sbjct: 180 EEFMDGYALSREDIKNPKFQKLIAKNLKLLHDIKLNENLYKELQVTQKVPGTRPSFLWNT 239 Query: 138 --KHLH-----SAGIIHRDLKPSNIVVKADCTLKILDF 168 K+ H I D K NI+ K++DF Sbjct: 240 IWKYFHLLNEERKKICSFDAKA-NIL-------KLIDF 269 >4M46-A nrPDB Length = 581 Score = 30.0 bits (66), Expect = 1.8, Method: Composition-based stats. Identities = 14/49 (28%), Positives = 23/49 (46%), Gaps = 5/49 (10%) Query: 314 ALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYEEVMDY 362 L+H +I +DA P P+ + +E+ K + +EVMDY Sbjct: 492 LLQHPFI---FDAGVAGIPDPD--AGELPAAVVVLEEGKTMTEQEVMDY 535 >4GYG-A nrPDB Length = 397 Score = 29.6 bits (65), Expect = 2.1, Method: Composition-based stats. Identities = 29/154 (18%), Positives = 54/154 (35%), Gaps = 28/154 (18%) Query: 25 INLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNII 84 + + +G + V A D + + S A +EF MK + Sbjct: 124 LKIHRLGRISFRTVKANRDYLRNR-------STGSWMYLSRLAAIKEFAFMKAL------ 170 Query: 85 GLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGIKHLHSAG 144 F + + + +VM L+DA + + D + L ++ I L G Sbjct: 171 -YEEGFPVPEPIAQSRHT-IVMSLVDALPMRQVSSVPDP---ASLYADLIALILRLAKHG 225 Query: 145 IIHRDLKPSNIVVKADCTLK----------ILDF 168 +IH D NI+++ + + I+DF Sbjct: 226 LIHGDFNEFNILIREEKDAEDPSSITLTPIIIDF 259 >2GWN-A nrPDB Length = 452 Score = 29.6 bits (65), Expect = 2.1, Method: Composition-based stats. Identities = 16/131 (12%), Positives = 41/131 (31%), Gaps = 23/131 (17%) Query: 215 EMIRGGVLFPGTDHIDQW---NKIIEQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDR 271 ++ G LF G+ + + +E++ + N+ Y + Sbjct: 146 HLVPGLKLFLGSSTGNMLVDNKETLEKIFGECDLLIATHCEKEEIIRANKEHYKAKYGND 205 Query: 272 LFPDGLFPNDNNQNSRRKASDARNLLSKM----------------LVID----PEQRISV 311 L + + R +++A L +M L + ++RI+ Sbjct: 206 LDIHFHPLIRSEEACYRSSAEAVELAERMNARLHILHLSTEKELSLFRNDIPTAQKRITS 265 Query: 312 DEALKHEYINV 322 + + H + + Sbjct: 266 EVCVHHLWFSD 276 >2COY-A nrPDB Length = 112 Score = 29.6 bits (65), Expect = 2.5, Method: Composition-based stats. Identities = 12/53 (22%), Positives = 18/53 (33%), Gaps = 5/53 (9%) Query: 2 TTAQHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIV--CAAYDTITQQNVAI 52 T + E + SR + IG G +G V A T + V + Sbjct: 18 RTPSGSRMSAEASARPLRVGSR---VEVIGKGHRGTVAYVGATLFATGKWVGV 67 >5LJ3-H nrPDB Length = 591 Score = 29.2 bits (64), Expect = 2.9, Method: Composition-based stats. Identities = 12/30 (40%), Positives = 17/30 (56%), Gaps = 1/30 (3%) Query: 147 HRDLKPSNIVVKADCTLK-ILDFGLARTAG 175 HRDL NI++ D K ++DF L + G Sbjct: 41 HRDLFQVNILIGRDIICKNVVDFTLNKQNG 70 >6EJB-A nrPDB Length = 751 Score = 29.2 bits (64), Expect = 3.1, Method: Composition-based stats. Identities = 20/85 (23%), Positives = 30/85 (35%), Gaps = 14/85 (16%) Query: 107 ELMDANLCQVIQMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKIL 166 E M AN ++ + + H R S L +M I H IH D K SN + Sbjct: 111 EYMPANPVRIAFVLVVHGRASRQLQRMFKAIYHKDHFYYIHVD-KRSNYL---------- 159 Query: 167 DFGLARTAGTTFMMTPYVVTRYYRA 191 + + + VT + A Sbjct: 160 ---HRQVLQVSRQYSNVRVTPWRMA 181 >4BFR-A nrPDB Length = 952 Score = 28.8 bits (63), Expect = 3.7, Method: Composition-based stats. Identities = 14/63 (22%), Positives = 20/63 (31%), Gaps = 10/63 (15%) Query: 107 ELMDANLCQVIQMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKIL 166 E + + Y + + GI HS NI+VK L + Sbjct: 769 EYNSGDDLDRAIEEFTLSCAGYCVASYVLGIGDRHS----------DNIMVKKTGQLFHI 818 Query: 167 DFG 169 DFG Sbjct: 819 DFG 821 >1A9C-A nrPDB Length = 221 Score = 28.8 bits (63), Expect = 4.0, Method: Composition-based stats. Identities = 14/91 (15%), Positives = 33/91 (36%), Gaps = 13/91 (14%) Query: 105 VMELMDANLCQVIQMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKA----D 160 +M+L++ +L M+ H + ++ G+ + + I +++ D Sbjct: 46 IMQLLNLDLADDSLMETPHRIAKMYVDEIFSGLDYANFPKIT---------LIENKMKVD 96 Query: 161 CTLKILDFGLARTAGTTFMMTPYVVTRYYRA 191 + + D L T+ F+ T Y Sbjct: 97 EMVTVRDITLTSTSEHHFVTIDGKATVAYIP 127 >6EN4-C nrPDB Length = 852 Score = 28.8 bits (63), Expect = 4.4, Method: Composition-based stats. Identities = 14/95 (14%), Positives = 27/95 (28%), Gaps = 6/95 (6%) Query: 209 VGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGT-----PSPSFMQRLQPTVRNYVENRPR 263 +G ++ E + + I+ +G P + RL P ++N E Sbjct: 522 LGVVLYEYLGEEYPEVLGSILGALKAIVNVIGMHKMTPPIKDLLPRLTPILKNRHEKVQE 581 Query: 264 YTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLS 298 D + + R + LL Sbjct: 582 NC-IDLVGRIADRGAEYVSAREWMRICFELLELLK 615 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.310 0.140 0.429 Lambda K H 0.267 0.0430 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 16,088,287 Number of Sequences: 36641 Number of extensions: 699095 Number of successful extensions: 5903 Number of sequences better than 10.0: 518 Number of HSP's better than 10.0 without gapping: 940 Number of HSP's successfully gapped in prelim test: 55 Number of HSP's that attempted gapping in prelim test: 1920 Number of HSP's gapped (non-prelim): 1418 length of query: 372 length of database: 10,336,785 effective HSP length: 99 effective length of query: 273 effective length of database: 6,709,326 effective search space: 1831645998 effective search space used: 1831645998 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.1 bits) S2: 60 (27.6 bits)