BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P80428 (489 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 3QB0-A nrPDB 1010 0.0 4I6M-A nrPDB 105 4e-23 5NW4-V nrPDB 105 4e-23 4PL7-A nrPDB 104 1e-22 3MN5-A nrPDB 102 5e-22 1C0F-A nrPDB 100 1e-21 5NBL-C nrPDB 100 2e-21 3ULE-B nrPDB 99 5e-21 5MVV-A nrPDB 98 1e-20 6F3A-A nrPDB 92 7e-19 4CBX-A nrPDB 86 3e-17 1K8K-A nrPDB 66 3e-11 3DWL-A nrPDB 57 3e-08 5NW4-X nrPDB 54 1e-07 6HTS-H nrPDB 44 2e-04 4FO0-A nrPDB 42 5e-04 3WEE-A nrPDB 39 0.004 4I6M-B nrPDB 39 0.006 6GEJ-R nrPDB 35 0.099 3PNZ-A nrPDB 34 0.11 5ZI4-A nrPDB 30 2.3 1P5U-C nrPDB 30 2.4 4AM6-A nrPDB 29 3.7 3K2H-A nrPDB 29 4.8 2BKW-A nrPDB 29 5.3 6ID0-C nrPDB 28 7.1 4PQK-A nrPDB 28 9.9 >3QB0-A nrPDB Length = 498 Score = 1010 bits (2612), Expect = 0.0, Method: Compositional matrix adjust. Identities = 489/489 (100%), Positives = 489/489 (100%) Query: 1 MSNAALQVYGGDEVSAVVIDPGSYTTNIGYSGSDFPQSILPSVYGKYTADEGNKKIFSEQ 60 MSNAALQVYGGDEVSAVVIDPGSYTTNIGYSGSDFPQSILPSVYGKYTADEGNKKIFSEQ Sbjct: 10 MSNAALQVYGGDEVSAVVIDPGSYTTNIGYSGSDFPQSILPSVYGKYTADEGNKKIFSEQ 69 Query: 61 SIGIPRKDYELKPIIENGLVIDWDTAQEQWQWALQNELYLNSNSGIPALLTEPVWNSTEN 120 SIGIPRKDYELKPIIENGLVIDWDTAQEQWQWALQNELYLNSNSGIPALLTEPVWNSTEN Sbjct: 70 SIGIPRKDYELKPIIENGLVIDWDTAQEQWQWALQNELYLNSNSGIPALLTEPVWNSTEN 129 Query: 121 RKKSLEVLLEGMQFEACYLAPTSTCVSFAAGRPNCLVVDIGHDTCSVSPIVDGMTLSKST 180 RKKSLEVLLEGMQFEACYLAPTSTCVSFAAGRPNCLVVDIGHDTCSVSPIVDGMTLSKST Sbjct: 130 RKKSLEVLLEGMQFEACYLAPTSTCVSFAAGRPNCLVVDIGHDTCSVSPIVDGMTLSKST 189 Query: 181 RRNFIAGKFINHLIKKALEPKEIIPLFAIKQRKPEFIKKTFDYEVDKSLYDYANNRGFFQ 240 RRNFIAGKFINHLIKKALEPKEIIPLFAIKQRKPEFIKKTFDYEVDKSLYDYANNRGFFQ Sbjct: 190 RRNFIAGKFINHLIKKALEPKEIIPLFAIKQRKPEFIKKTFDYEVDKSLYDYANNRGFFQ 249 Query: 241 ECKETLCHICPTKTLEETKTELSSTAKRSIESPWNEEIVFDNETRYGFAEELFLPKEDDI 300 ECKETLCHICPTKTLEETKTELSSTAKRSIESPWNEEIVFDNETRYGFAEELFLPKEDDI Sbjct: 250 ECKETLCHICPTKTLEETKTELSSTAKRSIESPWNEEIVFDNETRYGFAEELFLPKEDDI 309 Query: 301 PANWPRSNSGVVKTWRNDYVPLKRTKPSGVNKSDKKVTPTEEKEQEAVSKSTSPAANSAD 360 PANWPRSNSGVVKTWRNDYVPLKRTKPSGVNKSDKKVTPTEEKEQEAVSKSTSPAANSAD Sbjct: 310 PANWPRSNSGVVKTWRNDYVPLKRTKPSGVNKSDKKVTPTEEKEQEAVSKSTSPAANSAD 369 Query: 361 TPNETGKRPLEEEKPPKENNELIGLADLVYSSIMSSDVDLRATLAHNVVLTGGTSSIPGL 420 TPNETGKRPLEEEKPPKENNELIGLADLVYSSIMSSDVDLRATLAHNVVLTGGTSSIPGL Sbjct: 370 TPNETGKRPLEEEKPPKENNELIGLADLVYSSIMSSDVDLRATLAHNVVLTGGTSSIPGL 429 Query: 421 SDRLMTELNKILPSLKFRILTTGHTIERQYQSWLGGSILTSLGTFHQLWVGKKEYEEVGV 480 SDRLMTELNKILPSLKFRILTTGHTIERQYQSWLGGSILTSLGTFHQLWVGKKEYEEVGV Sbjct: 430 SDRLMTELNKILPSLKFRILTTGHTIERQYQSWLGGSILTSLGTFHQLWVGKKEYEEVGV 489 Query: 481 ERLLNDRFR 489 ERLLNDRFR Sbjct: 490 ERLLNDRFR 498 >4I6M-A nrPDB Length = 477 Score = 105 bits (263), Expect = 4e-23, Method: Compositional matrix adjust. Identities = 116/504 (23%), Positives = 212/504 (42%), Gaps = 82/504 (16%) Query: 17 VVIDPGSYTTNIGYSGSDFPQSILPSVYGKYTADEGNKKIFSEQSIGI------PRKDYE 70 VVI GS+ T G+S + PQ I+PS Y K T DEG + F + + R E Sbjct: 8 VVIHNGSHRTVAGFSNVELPQCIIPSSYIKRT-DEGGEAEFIFGTYNMIDAAAEKRNGDE 66 Query: 71 LKPIIEN-GLVIDWDTAQEQWQWALQNELYLNSNSGIPALLTEPVWNSTENR---KKSLE 126 + ++++ GL +WD + QW++ +L + S +P ++T P N + ++ E Sbjct: 67 VYTLVDSQGLPYNWDALEMQWRYLYDTQLKV-SPEELPLVITMPATNGKPDMAILERYYE 125 Query: 127 VLLEGMQFEACYLAPTSTCVSFAAGRPNCLVVDIGHDTCSVSPIVDGMTLSKSTRRNFIA 186 + + + + ++ + G+ + V+DIG C+V+PI+DG+ + + R+ Sbjct: 126 LAFDKLNVPVFQIVIEPLAIALSMGKSSAFVIDIGASGCNVTPIIDGIVVKNAVVRSKFG 185 Query: 187 GKFINHLIKKALEP----KEIIPLFAIKQRKP-----------EFIKKTFDYEVDKSLYD 231 G F++ + + L P + + A +Q++ + K T +K L++ Sbjct: 186 GDFLDFQVHERLAPLIKEENDMENMADEQKRSTDVWYEASTWIQQFKSTMLQVSEKDLFE 245 Query: 232 YANNRGFFQECKETLCHICPTKTLEETKTELSSTA------------KRSIESPWNEEIV 279 +++E + + + L++ +L TA K + P N+ + Sbjct: 246 LER---YYKEQAD--IYAKQQEQLKQMDQQLQYTALTGSPNNPLVQKKNFLFKPLNKTLT 300 Query: 280 FDNETRYGFAEELFLPKEDDIPANWPRSNSGVVKTWRNDYVPLKRTKPSGVNKSDKKVTP 339 D + Y FAE LF P + + + P P + KS KK Sbjct: 301 LDLKECYQFAEYLFKP-----------------QLISDKFSPEDGLGPL-MAKSVKK--- 339 Query: 340 TEEKEQEAVSKSTSPAANSADTPNETGKRPLEEEKPPKENNELIGLADLVYSSIMSSDVD 399 A + S AN++ PN G + N +G + SS S Sbjct: 340 -------AGASINSMKANTSTNPNGLGTSHI---------NTNVGDNNSTASSSNISPEQ 383 Query: 400 LRATLAHNVVLTGGTSSIPGLSDRLMTELNKILPSLKFRILTTGHTIERQYQSWLGGSIL 459 + + L NV++TG TS I G+ R++ EL+ P K ++R+ Q WLG + Sbjct: 384 VYSLLLTNVIITGSTSLIEGMEQRIIKELSIRFPQYKLTTFANQVMMDRKIQGWLGALTM 443 Query: 460 TSLGTFH-QLWVGKKEYEEVGVER 482 +L ++ W K++YE + +R Sbjct: 444 ANLPSWSLGKWYSKEDYETLKRDR 467 >5NW4-V nrPDB Length = 396 Score = 105 bits (262), Expect = 4e-23, Method: Compositional matrix adjust. Identities = 80/295 (27%), Positives = 125/295 (42%), Gaps = 32/295 (10%) Query: 6 LQVYGGDEVSAVVIDPGSYTTNIGYSGSDFPQSILPSVYGK-----YTADEGNKKIFSEQ 60 LQ G +E++A+V+D GS G++G D P+++ PS+ G+ G K + Sbjct: 18 LQTMGDEEIAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGD 77 Query: 61 SIGIPRKDYELKPIIENGLVIDWDTAQEQWQWALQNELYLNSNSGIPALLTEPVWNSTEN 120 R LK IE+G+V +WD ++ W NEL + P LLTE N N Sbjct: 78 EAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEH-PVLLTEAPLNPKAN 136 Query: 121 RKKSLEVLLEGMQFEACYLAPTSTCVSFAAGRPNCLVVDIGHDTCSVSPIVDGMTLSKST 180 R+K +++ E A Y+A + +A+GR +V+D G PI +G L + Sbjct: 137 REKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAI 196 Query: 181 RRNFIAGKFINHLIKKALEPKEIIPLFAIKQRKPEFIKKTFDYEVDKSLYDYANNRGFFQ 240 R +AG+ + + K L +R F R + Sbjct: 197 LRLDLAGRDLTDYLMKIL-----------TERGYSFTTTA--------------EREIVR 231 Query: 241 ECKETLCHICPTKTLEETKTELSSTAKRSIESPWNEEIVFDNETRYGFAEELFLP 295 + KE LC++ E SS+ ++S E P + I NE R+ E LF P Sbjct: 232 DIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNE-RFRCPEALFQP 285 Score = 96.7 bits (239), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 57/146 (39%), Positives = 83/146 (56%), Gaps = 13/146 (8%) Query: 344 EQE-AVSKSTSPAANSADTP--------NETGKRPLEEEKPPKENNELIGLADLVYSSIM 394 EQE A + S+S S + P NE + P +P E G+ + ++SIM Sbjct: 245 EQEMATAASSSSLEKSYELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETTFNSIM 304 Query: 395 SSDVDLRATLAHNVVLTGGTSSIPGLSDRLMTELNKILPS-LKFRILTTGHTIERQYQSW 453 DVD+R L N VL+GGT+ PG++DR+ E+ + PS +K +I+ ER+Y W Sbjct: 305 KCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPP---ERKYSVW 361 Query: 454 LGGSILTSLGTFHQLWVGKKEYEEVG 479 +GGSIL SL TF Q+W+ K+EY+E G Sbjct: 362 IGGSILASLSTFQQMWISKQEYDESG 387 >4PL7-A nrPDB Length = 440 Score = 104 bits (259), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 80/290 (27%), Positives = 124/290 (42%), Gaps = 32/290 (11%) Query: 11 GDEVSAVVIDPGSYTTNIGYSGSDFPQSILPSVYGK-----YTADEGNKKIFSEQSIGIP 65 G++V+A+VID GS GY+G D P ++ PSV G+ G K F Sbjct: 2 GEDVAALVIDNGSGMCKAGYAGDDAPHTVFPSVVGRPRHQGVMVGMGQKDSFVGDEAQSK 61 Query: 66 RKDYELKPIIENGLVIDWDTAQEQWQWALQNELYLNSNSGIPALLTEPVWNSTENRKKSL 125 R L+ IE+G+V +WD ++ W NEL L P LLTE N NR+K Sbjct: 62 RGILTLRYPIEHGIVTNWDDMEKIWHHTFYNELRLAPEEH-PVLLTEAPMNPKSNREKMT 120 Query: 126 EVLLEGMQFEACYLAPTSTCVSFAAGRPNCLVVDIGHDTCSVSPIVDGMTLSKSTRRNFI 185 +++ E A Y++ + +A+GR +V+D G V PI G +L + R + Sbjct: 121 QIMFETFNVPAFYVSIQAVLSLYASGRTTGIVLDSGDGVTHVVPIYAGFSLPHAILRIDL 180 Query: 186 AGKFINHLIKKALEPKEIIPLFAIKQRKPEFIKKTFDYEVDKSLYDYANNRGFFQECKET 245 AG+ + + K L + + + R ++ KE Sbjct: 181 AGRDLTDYLMKILSER-------------------------GYTFSTSAEREIVRDIKEK 215 Query: 246 LCHICPTKTLEETKTELSSTAKRSIESPWNEEIVFDNETRYGFAEELFLP 295 LC++ E + SS+ ++S E P + I NE R+ E LF P Sbjct: 216 LCYVALDFDQELQTSSQSSSIEKSYELPDGQVITIGNE-RFRAPEALFHP 264 Score = 96.3 bits (238), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 50/118 (42%), Positives = 71/118 (60%), Gaps = 4/118 (3%) Query: 363 NETGKRPLEEEKPPKENNELIGLADLVYSSIMSSDVDLRATLAHNVVLTGGTSSIPGLSD 422 NE + P P E G+ Y+SIM DVD+R L N+V++GGT+ PG+++ Sbjct: 252 NERFRAPEALFHPSVLGLEASGIDQTTYNSIMKCDVDVRKELYSNIVMSGGTTMFPGIAE 311 Query: 423 RLMTELNKILPS-LKFRILTTGHTIERQYQSWLGGSILTSLGTFHQLWVGKKEYEEVG 479 R+ EL + PS +K +I ER+Y W+GGSIL SLGTF Q+W+ K+EY+E G Sbjct: 312 RMQKELTALAPSSMKVKISAPP---ERKYSVWIGGSILASLGTFQQMWISKQEYDESG 366 >3MN5-A nrPDB Length = 359 Score = 102 bits (253), Expect = 5e-22, Method: Compositional matrix adjust. Identities = 78/284 (27%), Positives = 121/284 (42%), Gaps = 38/284 (13%) Query: 12 DEVSAVVIDPGSYTTNIGYSGSDFPQSILPSVYGKYTADEGNKKIFSEQSIGIPRKDYEL 71 DE +A+V D GS G++G D P+++ PS+ G+ DE K R L Sbjct: 3 DETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGR-VGDEAQSK----------RGILTL 51 Query: 72 KPIIENGLVIDWDTAQEQWQWALQNELYLNSNSGIPALLTEPVWNSTENRKKSLEVLLEG 131 K IE+G++ +WD ++ W NEL + P LLTE N NR+K +++ E Sbjct: 52 KYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEH-PTLLTEAPLNPKANREKMTQIMFET 110 Query: 132 MQFEACYLAPTSTCVSFAAGRPNCLVVDIGHDTCSVSPIVDGMTLSKSTRRNFIAGKFIN 191 A Y+A + +A+GR +V+D G PI +G L + R +AG+ + Sbjct: 111 FNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLT 170 Query: 192 HLIKKALEPKEIIPLFAIKQRKPEFIKKTFDYEVDKSLYDYANNRGFFQECKETLCHICP 251 + K L +R F+ R ++ KE LC++ Sbjct: 171 DYLMKIL-----------TERGYSFVTTA--------------EREIVRDIKEKLCYVAL 205 Query: 252 TKTLEETKTELSSTAKRSIESPWNEEIVFDNETRYGFAEELFLP 295 E SS+ ++S E P + I NE R+ E LF P Sbjct: 206 DFENEMATAASSSSLEKSYELPDGQVITIGNE-RFRCPETLFQP 248 Score = 94.7 bits (234), Expect = 7e-20, Method: Compositional matrix adjust. Identities = 48/118 (40%), Positives = 72/118 (61%), Gaps = 4/118 (3%) Query: 363 NETGKRPLEEEKPPKENNELIGLADLVYSSIMSSDVDLRATLAHNVVLTGGTSSIPGLSD 422 NE + P +P E G+ + Y+SIM D+D+R L N V++GGT+ PG++D Sbjct: 236 NERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMSGGTTMYPGIAD 295 Query: 423 RLMTELNKILPS-LKFRILTTGHTIERQYQSWLGGSILTSLGTFHQLWVGKKEYEEVG 479 R+ E+ + PS +K +I+ ER+Y W+GGSIL SL TF Q+W+ K+EY+E G Sbjct: 296 RMQKEITALAPSTMKIKIIAPP---ERKYSVWIGGSILASLSTFQQMWITKQEYDEAG 350 >1C0F-A nrPDB Length = 368 Score = 100 bits (249), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 80/293 (27%), Positives = 121/293 (41%), Gaps = 45/293 (15%) Query: 11 GDEVSAVVIDPGSYTTNIGYSGSDFPQSILPSVYGK--------YTADEGNKKIFSEQSI 62 G++V A+VID GS G++G D P+++ PS+ G+ Y DE K Sbjct: 2 GEDVQALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHTGKDSYVGDEAQSK------- 54 Query: 63 GIPRKDYELKPIIENGLVIDWDTAQEQWQWALQNELYLNSNSGIPALLTEPVWNSTENRK 122 R LK IE+G+V +WD ++ W NEL + P LLTE N NR+ Sbjct: 55 ---RGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEH-PVLLTEAPLNPKANRE 110 Query: 123 KSLEVLLEGMQFEACYLAPTSTCVSFAAGRPNCLVVDIGHDTCSVSPIVDGMTLSKSTRR 182 K +++ E A Y+A + +A+GR +V+D G PI +G L + R Sbjct: 111 KMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVSHTVPIYEGYALPHAILR 170 Query: 183 NFIAGKFINHLIKKALEPKEIIPLFAIKQRKPEFIKKTFDYEVDKSLYDYANNRGFFQEC 242 +AG+ + + K L +R F R ++ Sbjct: 171 LDLAGRDLTDYMMKIL-----------TERGYSFTTTA--------------EREIVRDI 205 Query: 243 KETLCHICPTKTLEETKTELSSTAKRSIESPWNEEIVFDNETRYGFAEELFLP 295 KE L ++ E SS ++S E P + I NE R+ E LF P Sbjct: 206 KEKLAYVALDFEAEMQTAASSSALEKSYELPDGQVITIGNE-RFRCPEALFQP 257 Score = 99.0 bits (245), Expect = 4e-21, Method: Compositional matrix adjust. Identities = 52/118 (44%), Positives = 73/118 (61%), Gaps = 4/118 (3%) Query: 363 NETGKRPLEEEKPPKENNELIGLADLVYSSIMSSDVDLRATLAHNVVLTGGTSSIPGLSD 422 NE + P +P E G+ + Y+SIM DVD+R L NVVL+GGT+ PG++D Sbjct: 245 NERFRCPEALFQPSFLGMESAGIHETTYNSIMKCDVDIRKDLYGNVVLSGGTTMFPGIAD 304 Query: 423 RLMTELNKILPS-LKFRILTTGHTIERQYQSWLGGSILTSLGTFHQLWVGKKEYEEVG 479 R+ EL + PS +K +I+ ER+Y W+GGSIL SL TF Q+W+ K+EY+E G Sbjct: 305 RMNKELTALAPSTMKIKIIAPP---ERKYSVWIGGSILASLSTFQQMWISKEEYDESG 359 >5NBL-C nrPDB Length = 375 Score = 99.8 bits (247), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 76/290 (26%), Positives = 123/290 (42%), Gaps = 36/290 (12%) Query: 13 EVSAVVIDPGSYTTNIGYSGSDFPQSILPSVYGK-----YTADEGNKKIFSEQSIGIPRK 67 EV+A+VID GS G++G D P+++ PS+ G+ G K + R Sbjct: 4 EVAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGIMVGMGQKDSYVGDEAQSKRG 63 Query: 68 DYELKPIIENGLVIDWDTAQEQWQWALQNELYLNSNSGIPALLTEPVWNSTENRKKSLEV 127 L+ IE+G+V +WD ++ W NEL + P LLTE N NR+K ++ Sbjct: 64 ILTLRYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEH-PVLLTEAPMNPKSNREKMTQI 122 Query: 128 LLEGMQFEACYLAPTSTCVSFAAGRPNCLVVDIGHDTCSVSPIVDGMTLSKSTRRNFIAG 187 + E A Y++ + +++GR +V+D G V PI G +L + R +AG Sbjct: 123 MFETFNVPAFYVSIQAVLSLYSSGRTTGIVLDSGDGVTHVVPIYAGFSLPHAILRIDLAG 182 Query: 188 KFINHLIKKALEPKEIIPLFAIKQRKPEFIKKTFDYEVDKSLYDYANN--RGFFQECKET 245 + + + K L + Y ++ R ++ KE Sbjct: 183 RDLTDYLMKILSERG---------------------------YSFSTTAEREIVRDIKEK 215 Query: 246 LCHICPTKTLEETKTELSSTAKRSIESPWNEEIVFDNETRYGFAEELFLP 295 LC++ E SS+ ++S E P + I NE R+ E LF P Sbjct: 216 LCYVALDFEQEMQTAAQSSSIEKSYELPDGQVITIGNE-RFRAPEALFHP 264 Score = 95.9 bits (237), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 53/146 (36%), Positives = 81/146 (55%), Gaps = 11/146 (7%) Query: 342 EKEQEAVSKSTS-------PAANSADTPNETGKRPLEEEKPPKENNELIGLADLVYSSIM 394 E+E + ++S+S P NE + P P E G+ Y+SIM Sbjct: 224 EQEMQTAAQSSSIEKSYELPDGQVITIGNERFRAPEALFHPSVLGLESAGIDQTTYNSIM 283 Query: 395 SSDVDLRATLAHNVVLTGGTSSIPGLSDRLMTELNKILP-SLKFRILTTGHTIERQYQSW 453 DVD+R L N+V++GGT+ PG+++R+ E+ + P S+K +I+ ER+Y W Sbjct: 284 KCDVDVRKELYGNIVMSGGTTMFPGIAERMQKEITALAPSSMKVKIIAPP---ERKYSVW 340 Query: 454 LGGSILTSLGTFHQLWVGKKEYEEVG 479 +GGSIL SL TF Q+W+ K+EY+E G Sbjct: 341 IGGSILASLTTFQQMWISKQEYDESG 366 >3ULE-B nrPDB Length = 394 Score = 98.6 bits (244), Expect = 5e-21, Method: Compositional matrix adjust. Identities = 62/193 (32%), Positives = 95/193 (49%), Gaps = 13/193 (6%) Query: 16 AVVIDPGSYTTNIGYSGSDFPQSILPSVYGK----YTADEGNKKIFSEQSIGIPRKDYEL 71 VV D G+ GY+GS+FP+ I P++ G+ T GN +I + + + + EL Sbjct: 8 VVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPIIRSTTKVGNIEI---KDLMVGDEASEL 64 Query: 72 KPIIE------NGLVIDWDTAQEQWQWALQNELYLNSNSGIPALLTEPVWNSTENRKKSL 125 + ++E NG+V +WD + W + E LLTEP N T+NR+K + Sbjct: 65 RSMLEVNYPMENGIVRNWDDMKHLWDYTFGPEKLNIDTRNCKILLTEPPMNPTKNREKIV 124 Query: 126 EVLLEGMQFEACYLAPTSTCVSFAAGRPNCLVVDIGHDTCSVSPIVDGMTLSKSTRRNFI 185 EV+ E QF Y+A + +A G +VVD G + P+ +G +L TRR I Sbjct: 125 EVMFETYQFSGVYVAIQAVLTLYAQGLLTGVVVDSGDGVTHICPVYEGFSLPHLTRRLDI 184 Query: 186 AGKFINHLIKKAL 198 AG+ I + K L Sbjct: 185 AGRDITRYLIKLL 197 Score = 61.2 bits (147), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 42/149 (28%), Positives = 72/149 (48%), Gaps = 16/149 (10%) Query: 348 VSKSTSPAANSADTPNETGKRPLEEEKPPKENNELIGLADLVYSSIMSSDVDLRATLAHN 407 V T P E + P +P N E +G+A+L++++I ++D+D R+ + Sbjct: 241 VESYTLPDGRIIKVGGERFEAPEALFQPHLINVEGVGVAELLFNTIQAADIDTRSEFYKH 300 Query: 408 VVLTGGTSSIPGLSDRLMTELNKI------------LPSLKFRILTTGHTIERQYQSWLG 455 +VL+GG++ PGL RL EL ++ L K RI R++ +LG Sbjct: 301 IVLSGGSTMYPGLPSRLERELKQLYLERVLKGDVEKLSKFKIRI---EDPPRRKHMVFLG 357 Query: 456 GSILTS-LGTFHQLWVGKKEYEEVGVERL 483 G++L + W+ ++EY+E GV L Sbjct: 358 GAVLADIMKDKDNFWMTRQEYQEKGVRVL 386 >5MVV-A nrPDB Length = 378 Score = 97.8 bits (242), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 78/291 (26%), Positives = 120/291 (41%), Gaps = 32/291 (10%) Query: 10 GGDEVSAVVIDPGSYTTNIGYSGSDFPQSILPSVYGK-----YTADEGNKKIFSEQSIGI 64 G ++V A+V+D GS G +G D P+S+ PS+ G+ K F Sbjct: 4 GEEDVQALVVDNGSGNVKAGVAGDDAPRSVFPSIVGRPKNPGIMVGMEEKDAFVGDEAQT 63 Query: 65 PRKDYELKPIIENGLVIDWDTAQEQWQWALQNELYLNSNSGIPALLTEPVWNSTENRKKS 124 R LK IE+G+V +WD ++ W NEL P LLTE N NR++ Sbjct: 64 KRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRAAPEEH-PVLLTEAPLNPKGNRERM 122 Query: 125 LEVLLEGMQFEACYLAPTSTCVSFAAGRPNCLVVDIGHDTCSVSPIVDGMTLSKSTRRNF 184 +++ E A Y+A + +++GR +V+D G PI +G L + R Sbjct: 123 TQIMFESFNVPAMYVAIQAVLSLYSSGRTTGIVLDSGDGVSHTVPIYEGYALPHAIMRLD 182 Query: 185 IAGKFINHLIKKALEPKEIIPLFAIKQRKPEFIKKTFDYEVDKSLYDYANNRGFFQECKE 244 +AG+ + + K L + F +K + ++ KE Sbjct: 183 LAGRDLTEYLMKILHER----------------GYGFSTSAEKEI---------VRDIKE 217 Query: 245 TLCHICPTKTLEETKTELSSTAKRSIESPWNEEIVFDNETRYGFAEELFLP 295 LC+I E +E SS ++S E P I NE R+ E LF P Sbjct: 218 KLCYIALNFDEEMKTSEQSSDIEKSYELPDGNIITVGNE-RFRCPEALFQP 267 Score = 87.0 bits (214), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 47/127 (37%), Positives = 72/127 (56%), Gaps = 4/127 (3%) Query: 354 PAANSADTPNETGKRPLEEEKPPKENNELIGLADLVYSSIMSSDVDLRATLAHNVVLTGG 413 P N NE + P +P E G+ ++SI DVD+R L N+VL+GG Sbjct: 246 PDGNIITVGNERFRCPEALFQPSFLGKEAAGIHTTTFNSIKKCDVDIRKDLYGNIVLSGG 305 Query: 414 TSSIPGLSDRLMTELNKILPS-LKFRILTTGHTIERQYQSWLGGSILTSLGTFHQLWVGK 472 T+ G+ +RL ++ + PS +K +++ ER+Y W+GGSIL+SL TF Q+W+ K Sbjct: 306 TTMYEGIGERLTRDITTLAPSTMKIKVVAPP---ERKYSVWIGGSILSSLSTFQQMWITK 362 Query: 473 KEYEEVG 479 +EY+E G Sbjct: 363 EEYDESG 369 >6F3A-A nrPDB Length = 376 Score = 91.7 bits (226), Expect = 7e-19, Method: Compositional matrix adjust. Identities = 47/106 (44%), Positives = 67/106 (63%), Gaps = 4/106 (3%) Query: 384 GLADLVYSSIMSSDVDLRATLAHNVVLTGGTSSIPGLSDRLMTELNKILP-SLKFRILTT 442 G+ +++ +I SD+DLR TL N+VL+GG++ G DRL++E+ K+ P +K RI Sbjct: 274 GIHEVLVFAIQKSDMDLRRTLFSNIVLSGGSTLFKGFGDRLLSEVKKLAPKDVKIRISAP 333 Query: 443 GHTIERQYQSWLGGSILTSLGTFHQLWVGKKEYEEVGVERLLNDRF 488 ER Y +W+GGSIL SL TF ++WV KKEYEE G + F Sbjct: 334 Q---ERLYSTWIGGSILASLDTFKKMWVSKKEYEEDGARSIHRKTF 376 Score = 79.0 bits (193), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 51/189 (26%), Positives = 85/189 (44%), Gaps = 9/189 (4%) Query: 17 VVIDPGSYTTNIGYSGSDFPQSILPSVYGK-------YTADEGNKKIFSEQSIGIPRKDY 69 VVID GS G++G P+ P+ G+ A EG+ IF R Sbjct: 12 VVIDNGSGVIKAGFAGDQIPKYCFPNYVGRPKHVRVMAGALEGD--IFIGPKAEEHRGLL 69 Query: 70 ELKPIIENGLVIDWDTAQEQWQWALQNELYLNSNSGIPALLTEPVWNSTENRKKSLEVLL 129 ++ +E+G+V DW+ + WQ+ + + P LLTE N +NR+++ EV Sbjct: 70 SIRYPMEHGIVKDWNDMERIWQYVYSKDQLQTFSEEHPVLLTEAPLNPRKNRERAAEVFF 129 Query: 130 EGMQFEACYLAPTSTCVSFAAGRPNCLVVDIGHDTCSVSPIVDGMTLSKSTRRNFIAGKF 189 E A +++ + +A GR +V+D G PI +G + S R IAG+ Sbjct: 130 ETFNVPALFISMQAVLSLYATGRTTGVVLDSGDGVTHAVPIYEGFAMPHSIMRIDIAGRD 189 Query: 190 INHLIKKAL 198 ++ ++ L Sbjct: 190 VSRFLRLYL 198 >4CBX-A nrPDB Length = 378 Score = 86.3 bits (212), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 47/127 (37%), Positives = 71/127 (55%), Gaps = 4/127 (3%) Query: 354 PAANSADTPNETGKRPLEEEKPPKENNELIGLADLVYSSIMSSDVDLRATLAHNVVLTGG 413 P N +E + P P E GL Y SIM D+D+R L +N+VL+GG Sbjct: 246 PDGNLITVGSERFRCPEALFNPSLIGRECPGLHITAYQSIMKCDIDIRKELYNNIVLSGG 305 Query: 414 TSSIPGLSDRLMTELNKIL-PSLKFRILTTGHTIERQYQSWLGGSILTSLGTFHQLWVGK 472 T+ + +RL E+ + PS+K +++ ER+Y W+GGSIL+SL TF ++W+ K Sbjct: 306 TTMYNYIGERLTNEMTSLAPPSMKIKVIAPP---ERKYSVWIGGSILSSLSTFQKMWITK 362 Query: 473 KEYEEVG 479 +EY+E G Sbjct: 363 EEYDESG 369 Score = 84.7 bits (208), Expect = 8e-17, Method: Compositional matrix adjust. Identities = 56/200 (28%), Positives = 89/200 (44%), Gaps = 26/200 (13%) Query: 12 DEVSAVVIDPGSYTTNIGYSGSDFPQSILPSVYGK---------------YTADEGNKKI 56 +E A+V+D GS G +G D P+ + PS+ G Y DE K Sbjct: 5 EESIALVVDNGSGMVKSGLAGDDAPKCVFPSIIGIPKMPNIMVGMEQKECYVGDEAQNK- 63 Query: 57 FSEQSIGIPRKDYELKPIIENGLVIDWDTAQEQWQWALQNELYLNSNSGIPALLTEPVWN 116 R LK IE+G+V +WD ++ W+ NEL ++ P LLTE N Sbjct: 64 ---------RGILTLKYPIEHGIVTNWDDMEKIWRHTFFNELRVSPEEH-PVLLTEAPLN 113 Query: 117 STENRKKSLEVLLEGMQFEACYLAPTSTCVSFAAGRPNCLVVDIGHDTCSVSPIVDGMTL 176 NR+K +++ E A Y++ + +A+GR +V+D G PI +G L Sbjct: 114 PKTNREKMTQIMFESFDVPAMYVSIQAILSLYASGRTTGIVLDSGDGVTHTVPIYEGYVL 173 Query: 177 SKSTRRNFIAGKFINHLIKK 196 + R +AG+ + + + K Sbjct: 174 PHAINRTDMAGRDLTYYMMK 193 >1K8K-A nrPDB Length = 418 Score = 66.2 bits (160), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 62/245 (25%), Positives = 102/245 (41%), Gaps = 33/245 (13%) Query: 16 AVVIDPGSYTTNIGYSGSDFPQSILPSVYG----KYTADEGNKKI--------FSEQSIG 63 A V+D G+ T +GY+G+ PQ I+PS D+ +++ F Sbjct: 7 ACVVDCGTGYTKLGYAGNTEPQFIIPSCIAIKESAKVGDQAQRRVMKGVDDLDFFIGDEA 66 Query: 64 IPRKDYELKPIIENGLVIDWDTAQEQWQWALQNELYLNSNSGIPALLTEPVWNSTENRKK 123 I + Y K I +G+V DWD + + + L LLTEP N+ ENR+ Sbjct: 67 IEKPTYATKWPIRHGIVEDWDLMERFMEQVIFKYLRAEPEDHY-FLLTEPPLNTPENREY 125 Query: 124 SLEVLLEGMQFEACYLAPTS--------TCVSFAAGRPNCLVVDIGHDTCSVSPIVDGMT 175 + E++ E Y+A + T V+D G V P+ +G Sbjct: 126 TAEIMFESFNVPGLYIAVQAVLALAASWTSRQVGERTLTGTVIDSGDGVTHVIPVAEGYV 185 Query: 176 LSKSTRRNFIAGKFINHLIKKALEPKEI-IP-------LFAIKQRK----PEFIKKTFDY 223 + + IAG+ I + I++ L +E+ IP A+K+R P+ +K+ Y Sbjct: 186 IGSCIKHIPIAGRDITYFIQQLLRDREVGIPPEQSLETAKAVKERYSYVCPDLVKEFNKY 245 Query: 224 EVDKS 228 + D S Sbjct: 246 DTDGS 250 Score = 52.4 bits (124), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 33/110 (30%), Positives = 56/110 (50%), Gaps = 16/110 (14%) Query: 385 LADLVYSSIMSSDVDLRATLAHNVVLTGGTSSIPGLSDRLMTELNKILPS-LKFRILTTG 443 ++++V I + +D+R L N+VL+GG++ RL +L + + + LK +G Sbjct: 296 ISEVVDEVIQNCPIDVRRPLYKNIVLSGGSTMFRDFGRRLQRDLKRTVDARLKLSEELSG 355 Query: 444 --------------HTIERQYQSWLGGSILTSLGTFHQLWVGKKEYEEVG 479 H ++R Y W GGS+L S F+Q+ KK+YEE+G Sbjct: 356 GRLKPKPIDVQVITHHMQR-YAVWFGGSMLASTPEFYQVCHTKKDYEEIG 404 >3DWL-A nrPDB Length = 427 Score = 56.6 bits (135), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 66/319 (20%), Positives = 111/319 (34%), Gaps = 67/319 (21%) Query: 17 VVIDPGSYTTNIGYSGSDFPQSILPSVYG----------------KYTADEGNKKIFSEQ 60 +++D G+ + +GY+G+D P + P+V Y A +G+ + S++ Sbjct: 8 IIMDNGTGYSKLGYAGNDAPSYVFPTVIATRSAGASSGPAVSSKPSYMASKGSGHLSSKR 67 Query: 61 S------------IGIPRKDYELKPIIENGLVIDWDTAQEQWQWALQNELYLNSNSGIPA 108 + + Y L I +G + +WD + WQ +L L Sbjct: 68 ATEDLDFFIGNDALKKASAGYSLDYPIRHGQIENWDHMERFWQQSLFKYLRCEPEDHY-F 126 Query: 109 LLTEPVWNSTENRKKSLEVLLEGMQFEACYLAPTS--------TCVSFAAGRPNCLVVDI 160 LLTEP N ENR+ + E++ E Y+A + T VVD Sbjct: 127 LLTEPPLNPPENRENTAEIMFESFNCAGLYIAVQAVLALAASWTSSKVTDRSLTGTVVDS 186 Query: 161 GHDTCSVSPIVDGMTLSKSTRRNFIAGKFINHLIKKALEPKEIIPLFAIKQRKPEFIKKT 220 G + P+ +G + S + +AG+ + + ++ L + Sbjct: 187 GDGVTHIIPVAEGYVIGSSIKTMPLAGRDVTYFVQSLLRDRN------------------ 228 Query: 221 FDYEVDKSLYDYANNRGFFQECKETLCHICP--TKTLEETKTELSSTAKRSIESPWNEEI 278 E D SL + KE C++CP K E K + ES Sbjct: 229 ---EPDSSLKTA-------ERIKEECCYVCPDIVKEFSRFDREPDRYLKYASESITGHST 278 Query: 279 VFDNETRYGFAEELFLPKE 297 D A E+F E Sbjct: 279 TIDVGFERFLAPEIFFNPE 297 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 32/112 (28%), Positives = 49/112 (43%), Gaps = 14/112 (12%) Query: 382 LIGLADLVYSSIMSSDVDLRATLAHNVVLTGGTSSIPGLSDRLMTELNKILPSLKFR--- 438 L L +LV + + SS +D+R L N+VL+GG++ +RL +L +I+ R Sbjct: 304 LTPLPELVDNVVQSSPIDVRKGLYKNIVLSGGSTLFKNFGNRLQRDLKRIVDERIHRSEM 363 Query: 439 ----------ILTTGHTIERQYQSWLGGSILTSLGTFHQLWVGKKEYEEVGV 480 + H +R W GGS+L F K +YEE G Sbjct: 364 LSGAKSGGVDVNVISHKRQRN-AVWFGGSLLAQTPEFGSYCHTKADYEEYGA 414 >5NW4-X nrPDB Length = 417 Score = 53.9 bits (128), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 37/113 (32%), Positives = 56/113 (49%), Gaps = 12/113 (10%) Query: 377 KENNELIGLADLVYSSIMSSDVDLRATLAHNVVLTGGTSSIPGLSDRLMTELN------- 429 +++NE +A L+ S+M +D R LA N+V+ GGTS +PG RL+ E+ Sbjct: 272 EQDNEEKSVATLILDSLMQCPIDTRKQLAENLVIIGGTSMLPGFLHRLLAEIRYLVEKPK 331 Query: 430 --KILPSLKFRILTTGHTIERQYQSWLGGSILTSL-GTFHQLWVGKKEYEEVG 479 K L + FRI T + +WLGG+I +L V K+ Y + G Sbjct: 332 YKKTLGTKTFRIHTP--PAKANCVAWLGGAIFGALQDILGSRSVSKEYYNQTG 382 Score = 41.6 bits (96), Expect = 9e-04, Method: Compositional matrix adjust. Identities = 44/171 (25%), Positives = 70/171 (40%), Gaps = 32/171 (18%) Query: 11 GDEVSAVVIDPGSYTTNIGYSGSDFPQSILPSVYGKYTADEGNKKIFSEQSIGIPRKDYE 70 G E +AVVID G T G++G P+ I+PSV K G+P Sbjct: 10 GGEKTAVVIDLGEAFTKCGFAGETGPRCIIPSVIKK---------------AGMP----- 49 Query: 71 LKPIIENGLVIDWDTAQEQWQWALQ---NELYLNSNSGIP----ALLTEPVWNSTENRKK 123 KPI V+ ++ E+ L+ + LY P ++ E V + R+ Sbjct: 50 -KPI----KVVQYNINTEELYSYLKEFIHILYFRHLLVNPRDRRVVVIESVLCPSHFRET 104 Query: 124 SLEVLLEGMQFEACYLAPTSTCVSFAAGRPNCLVVDIGHDTCSVSPIVDGM 174 VL + + + LAP+ G + +V+D G+ V PI +G+ Sbjct: 105 LTRVLFKYFEVPSVLLAPSHLMALLTLGINSAMVLDCGYRESLVLPIYEGI 155 >6HTS-H nrPDB Length = 607 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 44/170 (25%), Positives = 70/170 (41%), Gaps = 17/170 (10%) Query: 317 NDYVPLKRTKPSGVNKSDKKVTPTEEKEQEAVSKSTSPAANSADTPNETGKRPLEEEKPP 376 ND+ PL + GV K V P A + E + P +P Sbjct: 410 NDFDPLFSEETPGVEKPVTTVQPV----------FNLAAYHQLFVGTERIRAPEIIFQPS 459 Query: 377 KENNELIGLADLVYSSIMSSDVDLRATLAHNVVLTGGTSSIPGLSDRLMTELNKILP-SL 435 E G+A+ + + D++ L NV LTGG + PG+ R+ EL ++ P Sbjct: 460 LIGEEQAGIAETLQYILDRYPKDIQEMLVQNVFLTGGNTMYPGMKARMEKELLEMRPFRS 519 Query: 436 KFRILTTGHTIERQYQSWLGGS--ILTSLGTFHQLWVGKKEYEEVGVERL 483 F++ + + +W G L L +++W+ +KEYEE G E L Sbjct: 520 SFQVQLASNPV---LDAWYGARDWALNHLDD-NEVWITRKEYEEKGGEYL 565 >4FO0-A nrPDB Length = 593 Score = 42.4 bits (98), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 34/114 (29%), Positives = 58/114 (50%), Gaps = 12/114 (10%) Query: 383 IGLADLVYSSI--MSSDVDLRATLAHNVVLTGGTSSIPGLSDRLMTE-LNKILPSLKFRI 439 +GL + SI SSD D + + ++++ GG + L LNK+ PS + RI Sbjct: 478 LGLDKAILHSIDCCSSD-DTKKKMYSSILVVGGGLMFHKAQEFLQHRILNKMPPSFR-RI 535 Query: 440 LTTGHTIER------QYQSWLGGSILTSLGTFHQLWVGKKEYEEVGVERLLNDR 487 + I R + +W GG++L L T +LW+ ++E++ GV R+L +R Sbjct: 536 IENVDVITRPKDMDPRLIAWKGGAVLACLDTTQELWIYQREWQRFGV-RMLRER 588 Score = 34.7 bits (78), Expect = 0.084, Method: Compositional matrix adjust. Identities = 24/100 (24%), Positives = 46/100 (46%), Gaps = 3/100 (3%) Query: 90 WQWALQN--ELYLNSNSGIPALLTEPVWNSTENRKKSLEVLLEGMQFEACYLAPTSTCVS 147 W A+Q E+ L +L P + ++ K+ + ++L M F + S C + Sbjct: 181 WSHAIQKYLEIPLKDLKYYRCILLIPDIYNKQHVKELVNMILMKMGFSGIVVHQESVCAT 240 Query: 148 FAAGRPNCLVVDIGHDTCSVSPIVDGMTLSKSTRRNFIAG 187 + +G + +VD+G SV + DG++ ++TR G Sbjct: 241 YGSGLSSTCIVDVGDQKTSVCCVEDGVS-HRNTRLCLAYG 279 >3WEE-A nrPDB Length = 476 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 48/204 (23%), Positives = 86/204 (42%), Gaps = 29/204 (14%) Query: 15 SAVVIDPGSYTTNIGYSGSD----FPQSILPSVYGKYTADEGNKKIFSEQSIGIPRKDYE 70 S ++I P S TT + + ++ P+ +P+ + T +G+ ++ S K Sbjct: 17 SILIIYPRSQTTLVQFGLNEETFTVPELEIPTQIYRTTRQDGS---YTYHSTNKDNKAEL 73 Query: 71 LKPIIENGLVIDWDTAQEQWQWALQNELYLNSN----------SGIPALL-TEPVWNSTE 119 +KPI +NG +ID + + + L +N S IP LL T W+ ++ Sbjct: 74 IKPI-QNGEIIDISAFTQFLRLIFVSILSDRANKNQDAFEAELSNIPLLLITHHSWSQSD 132 Query: 120 NRKKSLEVL----LEGMQFEACYLAPTSTCVSFAA-GRPNCLVVDIGHDTCSVSPIVDGM 174 LE++ E ++ P S +++ NC ++D+G + PIVD Sbjct: 133 -----LEIITQYVFESLEINNLIQLPASLAATYSMISLQNCCIIDVGTHHTDIIPIVDYA 187 Query: 175 TLSKSTRRNFIAGKFINHLIKKAL 198 L + G+ IN +KK L Sbjct: 188 QLDHLVSSIPMGGQSINDSLKKLL 211 Score = 28.1 bits (61), Expect = 8.4, Method: Compositional matrix adjust. Identities = 11/34 (32%), Positives = 21/34 (61%) Query: 397 DVDLRATLAHNVVLTGGTSSIPGLSDRLMTELNK 430 D++ + N+++ GGT+SI G + L+ +L K Sbjct: 331 DINKAKAVWENIIIVGGTTSISGFKEALLGQLLK 364 >4I6M-B nrPDB Length = 439 Score = 38.5 bits (88), Expect = 0.006, Method: Compositional matrix adjust. Identities = 47/200 (23%), Positives = 84/200 (42%), Gaps = 21/200 (10%) Query: 15 SAVVIDPGSYTTNIGYSGSD----FPQSILPSVYGKYTADEGNKKIFSEQSIGIPRKDYE 70 S ++I P S TT + + ++ P+ +P+ + T +G+ ++ S K Sbjct: 8 SILIIYPRSQTTLVQFGLNEETFTVPELEIPTQIYRTTRQDGS---YTYHSTNKDNKAEL 64 Query: 71 LKPIIENGLVIDWDTAQEQWQWALQNELYLNSN----------SGIPALL-TEPVWNSTE 119 +KPI +NG +ID + + + L +N S IP LL T W S Sbjct: 65 IKPI-QNGEIIDISAFTQFLRLIFVSILSDRANKNQDAFEAELSNIPLLLITHHSW-SQS 122 Query: 120 NRKKSLEVLLEGMQFEACYLAPTSTCVSFAA-GRPNCLVVDIGHDTCSVSPIVDGMTLSK 178 + + + + E ++ P S +++ NC ++D+G + PIVD L Sbjct: 123 DLEIITQYVFESLEINNLIQLPASLAATYSMISLQNCCIIDVGTHHTDIIPIVDYAQLDH 182 Query: 179 STRRNFIAGKFINHLIKKAL 198 + G+ IN +KK L Sbjct: 183 LVSSIPMGGQSINDSLKKLL 202 Score = 28.1 bits (61), Expect = 7.9, Method: Compositional matrix adjust. Identities = 11/34 (32%), Positives = 21/34 (61%) Query: 397 DVDLRATLAHNVVLTGGTSSIPGLSDRLMTELNK 430 D++ + N+++ GGT+SI G + L+ +L K Sbjct: 294 DINKAKAVWENIIIVGGTTSISGFKEALLGQLLK 327 >6GEJ-R nrPDB Length = 438 Score = 34.7 bits (78), Expect = 0.099, Method: Compositional matrix adjust. Identities = 24/108 (22%), Positives = 48/108 (44%), Gaps = 7/108 (6%) Query: 384 GLADLVYSSIMSSDVDLRATLAHNVVLTGGTSSIPGLSDRLMTELNKILPSLKFRILTTG 443 G+ + + S+ +R + N+V TGG ++P + RL EL + LP+ T Sbjct: 329 GIVEAILESLSMLPEIVRPLMVGNIVCTGGNFNLPNFAQRLAAELQRQLPT----DWTCH 384 Query: 444 HTIERQYQSWLGGSILTSLG---TFHQLWVGKKEYEEVGVERLLNDRF 488 ++ + G +++ ++ + V ++EY E G + RF Sbjct: 385 VSVPEGDCALFGWEVMSQFAKTDSYRKARVTREEYYEHGPDWCTKHRF 432 Score = 34.3 bits (77), Expect = 0.14, Method: Compositional matrix adjust. Identities = 49/237 (20%), Positives = 85/237 (35%), Gaps = 58/237 (24%) Query: 13 EVSAVVIDPGSYTTNIGYSGSDFPQSILPSV----YGKYTADEGNKKIFSEQSIGIPRKD 68 E +VID GSY G S + P L ++ +G K I SI R+ Sbjct: 2 ETPPIVIDNGSYEIKFGPSTNKKPFRALNALAKDKFGTSYLSNHIKNIKDISSITF-RRP 60 Query: 69 YELKPIIENGLVIDWDTAQEQWQWALQNE-----LYLNSNSGIPALLTEPVWNSTENRKK 123 +EL G + W+ W + L N L G + +E E K Sbjct: 61 HEL------GQLTLWELESCIWDYCLFNPSEFDGFDLKEGKGHHLVASESCMTLPELSKH 114 Query: 124 SLEVLLEGMQFEACYLAPTSTCVSFA----------AGRPN------------------- 154 + +V+ E +F++ + +P + V F +G+ Sbjct: 115 ADQVIFEEYEFDSLFKSPVAVFVPFTKSYKGEMRTISGKDEDIDIVRGNSDSTNSTSSES 174 Query: 155 -------------CLVVDIGHDTCSVSPIVDGMTLSKSTRRNFIAGKFINHLIKKAL 198 LV+D G + + P++ G+ K+ ++ I G+F+ L+K+ L Sbjct: 175 KNAQDSGSDYHDFQLVIDSGFNCTWIIPVLKGIPYYKAVKKLDIGGRFLTGLLKETL 231 >3PNZ-A nrPDB Length = 330 Score = 34.3 bits (77), Expect = 0.11, Method: Compositional matrix adjust. Identities = 33/127 (25%), Positives = 49/127 (38%), Gaps = 13/127 (10%) Query: 337 VTPTEEKEQEAVSKSTSPAANSADTPNETGKRPLEEEKPPKENNELIGLADLVYSSIMSS 396 +TP EEK AV+++ + E G LE+ + K+ N L Y SI Sbjct: 162 ITPLEEKTIRAVARAHHETKAPIHSHTEAGTMALEQIEILKQEN-----IPLEYLSIGHM 216 Query: 397 DVDLRATLAHNVVLTGGTSSIPGL--------SDRLMTELNKILPSLKFRILTTGHTIER 448 D +L V TG S G+ S R+ L + + +IL +G T + Sbjct: 217 DRNLDPYYHKQVAKTGAFMSFDGIAKIKYAPESARIAAILYLVSEGFEDQILVSGDTARK 276 Query: 449 QYQSWLG 455 Y G Sbjct: 277 TYYKHYG 283 >5ZI4-A nrPDB Length = 345 Score = 30.0 bits (66), Expect = 2.3, Method: Compositional matrix adjust. Identities = 24/92 (26%), Positives = 42/92 (45%), Gaps = 17/92 (18%) Query: 9 YGGDEVSAVVIDPGSYTTNIGYSGSDFPQSILPSVYGKYTADE-------------GNKK 55 +GGDE+ GS T ++ ++G+ F + +L S + + E G K Sbjct: 220 FGGDEIVKAKQGAGSATLSMAFAGAKFAEEVLRSFHNEKPETESLSAFVYLPGLKNGKK- 278 Query: 56 IFSEQSIGIPRKDYELKPII-ENGLVIDWDTA 86 ++Q +G +Y PI+ NG V+ DT+ Sbjct: 279 --AQQLVGDNSIEYFSLPIVLRNGSVVSIDTS 308 >1P5U-C nrPDB Length = 147 Score = 30.0 bits (66), Expect = 2.4, Method: Composition-based stats. Identities = 13/52 (25%), Positives = 26/52 (50%) Query: 22 GSYTTNIGYSGSDFPQSILPSVYGKYTADEGNKKIFSEQSIGIPRKDYELKP 73 G Y T + +F + +Y +T+ +GN F+ + IG +D+++ P Sbjct: 47 GGYKTGTTSTSVNFTDAAGDPMYLTFTSQDGNNHQFTTKVIGKDSRDFDISP 98 >4AM6-A nrPDB Length = 655 Score = 29.3 bits (64), Expect = 3.7, Method: Compositional matrix adjust. Identities = 21/76 (27%), Positives = 35/76 (46%), Gaps = 5/76 (6%) Query: 360 DTPNETGKRPLEEEKPPKENNELIGLADLVYSSIMSSDVDLRATLAHNVVLTGGTSSIPG 419 D P G L+E P E + + ++ +++DV + N+++ GG+S IP Sbjct: 461 DKPENYGNT-LKENFAPLEK----AIVQSIANASITADVTRMNSFYSNILIVGGSSKIPA 515 Query: 420 LSDRLMTELNKILPSL 435 L L +N PSL Sbjct: 516 LDFILTDRINIWRPSL 531 >3K2H-A nrPDB Length = 511 Score = 28.9 bits (63), Expect = 4.8, Method: Compositional matrix adjust. Identities = 19/53 (35%), Positives = 28/53 (52%), Gaps = 7/53 (13%) Query: 388 LVYSSIMSSDVDLRATLAHNVVLTGGTSSI------PGLSDRL-MTELNKILP 433 LVY + ++ DLRA + HN + G S + GL D++ +T LNK P Sbjct: 99 LVYEDLSTAIRDLRANVPHNKIFILGGSFLYKEVLDNGLCDKIYLTRLNKEYP 151 >2BKW-A nrPDB Length = 385 Score = 28.9 bits (63), Expect = 5.3, Method: Compositional matrix adjust. Identities = 18/44 (40%), Positives = 22/44 (50%), Gaps = 3/44 (6%) Query: 68 DYELKPIIENGLVIDWDTAQEQWQW---ALQNELYLNSNSGIPA 108 D LK I+E GL WD +E W +L N L L S S P+ Sbjct: 268 DVALKEILEEGLHKRWDLHREMSDWFKDSLVNGLQLTSVSRYPS 311 >6ID0-C nrPDB Length = 972 Score = 28.5 bits (62), Expect = 7.1, Method: Compositional matrix adjust. Identities = 32/107 (29%), Positives = 46/107 (42%), Gaps = 11/107 (10%) Query: 330 VNKSDKKVTPTEEK----EQEAVSK--STSPAANSADTPNETGKRPLEEEKPPKENNELI 383 V DKK PT E+ E E + + T P P +T K L E+ P E+ Sbjct: 58 VLHEDKKYYPTAEEVYGPEVETIVQEEDTQPLTEPIIKPVKTKKFTLMEQTLPVTVYEMD 117 Query: 384 GLADLVYSSIMSSDVDLRATLAHNVVLTGGTSSIPGLSDRLMTELNK 430 LADL+ +S + +V L L H G T + L ++ E+ K Sbjct: 118 FLADLMDNSELIRNVTLCGHLHH-----GKTCFVDCLIEQTHPEIRK 159 >4PQK-A nrPDB Length = 487 Score = 28.1 bits (61), Expect = 9.9, Method: Compositional matrix adjust. Identities = 29/131 (22%), Positives = 57/131 (43%), Gaps = 2/131 (1%) Query: 350 KSTSPAANSADTPNETGKRPLEEEKPPKENNELIGLADLVYSSIMSSDVDLRATLAHNVV 409 ++ A A T N K L +E P + N L+ D I+ + V L+A + N Sbjct: 356 QTVDEALKDAQTHNFDDKEMLLQEFPEQLTNYLLKY-DYRDLEIIKA-VILKAKKSFNSR 413 Query: 410 LTGGTSSIPGLSDRLMTELNKILPSLKFRILTTGHTIERQYQSWLGGSILTSLGTFHQLW 469 + + D ++T L ++ ++ R + + Q++L +ILT L H L+ Sbjct: 414 HEDMHYMLEDIEDEILTSLKRLKKAIHDRGVKGQKETIKSMQAYLMQTILTELEETHALY 473 Query: 470 VGKKEYEEVGV 480 + +K ++ + Sbjct: 474 MRRKNMKQYNI 484 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 3QB0-A nrPDB 653 0.0 4I6M-A nrPDB 409 e-114 5NW4-V nrPDB 388 e-108 5NBL-C nrPDB 374 e-104 1C0F-A nrPDB 366 e-102 5MVV-A nrPDB 366 e-101 4PL7-A nrPDB 365 e-101 3MN5-A nrPDB 361 e-100 4CBX-A nrPDB 331 4e-91 3ULE-B nrPDB 309 2e-84 3DWL-A nrPDB 300 9e-82 6F3A-A nrPDB 283 1e-76 1K8K-A nrPDB 251 6e-67 5NW4-X nrPDB 241 4e-64 6HTS-H nrPDB 235 4e-62 4FO0-A nrPDB 143 2e-34 Sequences not found previously or not previously below threshold: 6GEJ-R nrPDB 125 3e-29 4AM6-A nrPDB 78 1e-14 4I6M-B nrPDB 64 1e-10 3WEE-A nrPDB 64 1e-10 5LY3-A nrPDB 46 5e-05 5LJV-A nrPDB 43 3e-04 3H1Q-A nrPDB 35 0.087 1JCE-A nrPDB 33 0.39 5WLC-LS nrPDB 31 1.0 6FKM-A nrPDB 31 1.1 5LNF-A nrPDB 31 1.3 3WQT-A nrPDB 31 1.3 3Q5R-A nrPDB 30 2.9 6NU3-AV nrPDB 29 4.8 2DU7-A nrPDB 29 5.4 2WL8-A nrPDB 28 7.2 >3QB0-A nrPDB Length = 498 Score = 653 bits (1684), Expect = 0.0, Method: Composition-based stats. Identities = 489/489 (100%), Positives = 489/489 (100%) Query: 1 MSNAALQVYGGDEVSAVVIDPGSYTTNIGYSGSDFPQSILPSVYGKYTADEGNKKIFSEQ 60 MSNAALQVYGGDEVSAVVIDPGSYTTNIGYSGSDFPQSILPSVYGKYTADEGNKKIFSEQ Sbjct: 10 MSNAALQVYGGDEVSAVVIDPGSYTTNIGYSGSDFPQSILPSVYGKYTADEGNKKIFSEQ 69 Query: 61 SIGIPRKDYELKPIIENGLVIDWDTAQEQWQWALQNELYLNSNSGIPALLTEPVWNSTEN 120 SIGIPRKDYELKPIIENGLVIDWDTAQEQWQWALQNELYLNSNSGIPALLTEPVWNSTEN Sbjct: 70 SIGIPRKDYELKPIIENGLVIDWDTAQEQWQWALQNELYLNSNSGIPALLTEPVWNSTEN 129 Query: 121 RKKSLEVLLEGMQFEACYLAPTSTCVSFAAGRPNCLVVDIGHDTCSVSPIVDGMTLSKST 180 RKKSLEVLLEGMQFEACYLAPTSTCVSFAAGRPNCLVVDIGHDTCSVSPIVDGMTLSKST Sbjct: 130 RKKSLEVLLEGMQFEACYLAPTSTCVSFAAGRPNCLVVDIGHDTCSVSPIVDGMTLSKST 189 Query: 181 RRNFIAGKFINHLIKKALEPKEIIPLFAIKQRKPEFIKKTFDYEVDKSLYDYANNRGFFQ 240 RRNFIAGKFINHLIKKALEPKEIIPLFAIKQRKPEFIKKTFDYEVDKSLYDYANNRGFFQ Sbjct: 190 RRNFIAGKFINHLIKKALEPKEIIPLFAIKQRKPEFIKKTFDYEVDKSLYDYANNRGFFQ 249 Query: 241 ECKETLCHICPTKTLEETKTELSSTAKRSIESPWNEEIVFDNETRYGFAEELFLPKEDDI 300 ECKETLCHICPTKTLEETKTELSSTAKRSIESPWNEEIVFDNETRYGFAEELFLPKEDDI Sbjct: 250 ECKETLCHICPTKTLEETKTELSSTAKRSIESPWNEEIVFDNETRYGFAEELFLPKEDDI 309 Query: 301 PANWPRSNSGVVKTWRNDYVPLKRTKPSGVNKSDKKVTPTEEKEQEAVSKSTSPAANSAD 360 PANWPRSNSGVVKTWRNDYVPLKRTKPSGVNKSDKKVTPTEEKEQEAVSKSTSPAANSAD Sbjct: 310 PANWPRSNSGVVKTWRNDYVPLKRTKPSGVNKSDKKVTPTEEKEQEAVSKSTSPAANSAD 369 Query: 361 TPNETGKRPLEEEKPPKENNELIGLADLVYSSIMSSDVDLRATLAHNVVLTGGTSSIPGL 420 TPNETGKRPLEEEKPPKENNELIGLADLVYSSIMSSDVDLRATLAHNVVLTGGTSSIPGL Sbjct: 370 TPNETGKRPLEEEKPPKENNELIGLADLVYSSIMSSDVDLRATLAHNVVLTGGTSSIPGL 429 Query: 421 SDRLMTELNKILPSLKFRILTTGHTIERQYQSWLGGSILTSLGTFHQLWVGKKEYEEVGV 480 SDRLMTELNKILPSLKFRILTTGHTIERQYQSWLGGSILTSLGTFHQLWVGKKEYEEVGV Sbjct: 430 SDRLMTELNKILPSLKFRILTTGHTIERQYQSWLGGSILTSLGTFHQLWVGKKEYEEVGV 489 Query: 481 ERLLNDRFR 489 ERLLNDRFR Sbjct: 490 ERLLNDRFR 498 >4I6M-A nrPDB Length = 477 Score = 409 bits (1051), Expect = e-114, Method: Composition-based stats. Identities = 115/504 (22%), Positives = 212/504 (42%), Gaps = 82/504 (16%) Query: 17 VVIDPGSYTTNIGYSGSDFPQSILPSVYGKYTADEGNKKIFSEQSIGI------PRKDYE 70 VVI GS+ T G+S + PQ I+PS Y K T DEG + F + + R E Sbjct: 8 VVIHNGSHRTVAGFSNVELPQCIIPSSYIKRT-DEGGEAEFIFGTYNMIDAAAEKRNGDE 66 Query: 71 LKPIIEN-GLVIDWDTAQEQWQWALQNELYLNSNSGIPALLTEPVWNSTENR---KKSLE 126 + ++++ GL +WD + QW++ +L ++ +P ++T P N + ++ E Sbjct: 67 VYTLVDSQGLPYNWDALEMQWRYLYDTQLKVSPEE-LPLVITMPATNGKPDMAILERYYE 125 Query: 127 VLLEGMQFEACYLAPTSTCVSFAAGRPNCLVVDIGHDTCSVSPIVDGMTLSKSTRRNFIA 186 + + + + ++ + G+ + V+DIG C+V+PI+DG+ + + R+ Sbjct: 126 LAFDKLNVPVFQIVIEPLAIALSMGKSSAFVIDIGASGCNVTPIIDGIVVKNAVVRSKFG 185 Query: 187 GKFINHLIKKALEP----KEIIPLFAIKQRKP-----------EFIKKTFDYEVDKSLYD 231 G F++ + + L P + + A +Q++ + K T +K L++ Sbjct: 186 GDFLDFQVHERLAPLIKEENDMENMADEQKRSTDVWYEASTWIQQFKSTMLQVSEKDLFE 245 Query: 232 YANNRGFFQECKETLCHICPTKTLEETKTELSSTA------------KRSIESPWNEEIV 279 +++E + + + L++ +L TA K + P N+ + Sbjct: 246 LER---YYKEQAD--IYAKQQEQLKQMDQQLQYTALTGSPNNPLVQKKNFLFKPLNKTLT 300 Query: 280 FDNETRYGFAEELFLPKEDDIPANWPRSNSGVVKTWRNDYVPLKRTKPSGVNKSDKKVTP 339 D + Y FAE LF P + + + P P + KS KK Sbjct: 301 LDLKECYQFAEYLFKP-----------------QLISDKFSPEDGLGPL-MAKSVKK--- 339 Query: 340 TEEKEQEAVSKSTSPAANSADTPNETGKRPLEEEKPPKENNELIGLADLVYSSIMSSDVD 399 A + S AN++ PN G + N +G + SS S Sbjct: 340 -------AGASINSMKANTSTNPNGLGTSHI---------NTNVGDNNSTASSSNISPEQ 383 Query: 400 LRATLAHNVVLTGGTSSIPGLSDRLMTELNKILPSLKFRILTTGHTIERQYQSWLGGSIL 459 + + L NV++TG TS I G+ R++ EL+ P K ++R+ Q WLG + Sbjct: 384 VYSLLLTNVIITGSTSLIEGMEQRIIKELSIRFPQYKLTTFANQVMMDRKIQGWLGALTM 443 Query: 460 TSLGTFH-QLWVGKKEYEEVGVER 482 +L ++ W K++YE + +R Sbjct: 444 ANLPSWSLGKWYSKEDYETLKRDR 467 >5NW4-V nrPDB Length = 396 Score = 388 bits (995), Expect = e-108, Method: Composition-based stats. Identities = 80/295 (27%), Positives = 125/295 (42%), Gaps = 32/295 (10%) Query: 6 LQVYGGDEVSAVVIDPGSYTTNIGYSGSDFPQSILPSVYGK-----YTADEGNKKIFSEQ 60 LQ G +E++A+V+D GS G++G D P+++ PS+ G+ G K + Sbjct: 18 LQTMGDEEIAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGD 77 Query: 61 SIGIPRKDYELKPIIENGLVIDWDTAQEQWQWALQNELYLNSNSGIPALLTEPVWNSTEN 120 R LK IE+G+V +WD ++ W NEL + P LLTE N N Sbjct: 78 EAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEH-PVLLTEAPLNPKAN 136 Query: 121 RKKSLEVLLEGMQFEACYLAPTSTCVSFAAGRPNCLVVDIGHDTCSVSPIVDGMTLSKST 180 R+K +++ E A Y+A + +A+GR +V+D G PI +G L + Sbjct: 137 REKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAI 196 Query: 181 RRNFIAGKFINHLIKKALEPKEIIPLFAIKQRKPEFIKKTFDYEVDKSLYDYANNRGFFQ 240 R +AG+ + + K L +R F R + Sbjct: 197 LRLDLAGRDLTDYLMKIL-----------TERGYSFTTTA--------------EREIVR 231 Query: 241 ECKETLCHICPTKTLEETKTELSSTAKRSIESPWNEEIVFDNETRYGFAEELFLP 295 + KE LC++ E SS+ ++S E P + I NE R+ E LF P Sbjct: 232 DIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNE-RFRCPEALFQP 285 Score = 205 bits (521), Expect = 3e-53, Method: Composition-based stats. Identities = 55/155 (35%), Positives = 82/155 (52%), Gaps = 11/155 (7%) Query: 342 EKEQEAVSKSTS-------PAANSADTPNETGKRPLEEEKPPKENNELIGLADLVYSSIM 394 E+E + S+S P NE + P +P E G+ + ++SIM Sbjct: 245 EQEMATAASSSSLEKSYELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETTFNSIM 304 Query: 395 SSDVDLRATLAHNVVLTGGTSSIPGLSDRLMTELNKILPS-LKFRILTTGHTIERQYQSW 453 DVD+R L N VL+GGT+ PG++DR+ E+ + PS +K +I+ ER+Y W Sbjct: 305 KCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPP---ERKYSVW 361 Query: 454 LGGSILTSLGTFHQLWVGKKEYEEVGVERLLNDRF 488 +GGSIL SL TF Q+W+ K+EY+E G + F Sbjct: 362 IGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF 396 >5NBL-C nrPDB Length = 375 Score = 374 bits (959), Expect = e-104, Method: Composition-based stats. Identities = 75/290 (25%), Positives = 121/290 (41%), Gaps = 32/290 (11%) Query: 11 GDEVSAVVIDPGSYTTNIGYSGSDFPQSILPSVYGK-----YTADEGNKKIFSEQSIGIP 65 EV+A+VID GS G++G D P+++ PS+ G+ G K + Sbjct: 2 DSEVAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGIMVGMGQKDSYVGDEAQSK 61 Query: 66 RKDYELKPIIENGLVIDWDTAQEQWQWALQNELYLNSNSGIPALLTEPVWNSTENRKKSL 125 R L+ IE+G+V +WD ++ W NEL + P LLTE N NR+K Sbjct: 62 RGILTLRYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEH-PVLLTEAPMNPKSNREKMT 120 Query: 126 EVLLEGMQFEACYLAPTSTCVSFAAGRPNCLVVDIGHDTCSVSPIVDGMTLSKSTRRNFI 185 +++ E A Y++ + +++GR +V+D G V PI G +L + R + Sbjct: 121 QIMFETFNVPAFYVSIQAVLSLYSSGRTTGIVLDSGDGVTHVVPIYAGFSLPHAILRIDL 180 Query: 186 AGKFINHLIKKALEPKEIIPLFAIKQRKPEFIKKTFDYEVDKSLYDYANNRGFFQECKET 245 AG+ + + K L + + R ++ KE Sbjct: 181 AGRDLTDYLMKILSER-------------------------GYSFSTTAEREIVRDIKEK 215 Query: 246 LCHICPTKTLEETKTELSSTAKRSIESPWNEEIVFDNETRYGFAEELFLP 295 LC++ E SS+ ++S E P + I NE R+ E LF P Sbjct: 216 LCYVALDFEQEMQTAAQSSSIEKSYELPDGQVITIGNE-RFRAPEALFHP 264 Score = 199 bits (506), Expect = 2e-51, Method: Composition-based stats. Identities = 54/155 (34%), Positives = 84/155 (54%), Gaps = 11/155 (7%) Query: 342 EKEQEAVSKSTS-------PAANSADTPNETGKRPLEEEKPPKENNELIGLADLVYSSIM 394 E+E + ++S+S P NE + P P E G+ Y+SIM Sbjct: 224 EQEMQTAAQSSSIEKSYELPDGQVITIGNERFRAPEALFHPSVLGLESAGIDQTTYNSIM 283 Query: 395 SSDVDLRATLAHNVVLTGGTSSIPGLSDRLMTELNKILP-SLKFRILTTGHTIERQYQSW 453 DVD+R L N+V++GGT+ PG+++R+ E+ + P S+K +I+ ER+Y W Sbjct: 284 KCDVDVRKELYGNIVMSGGTTMFPGIAERMQKEITALAPSSMKVKIIAPP---ERKYSVW 340 Query: 454 LGGSILTSLGTFHQLWVGKKEYEEVGVERLLNDRF 488 +GGSIL SL TF Q+W+ K+EY+E G + + F Sbjct: 341 IGGSILASLTTFQQMWISKQEYDESGPSIVHHKCF 375 Score = 29.1 bits (63), Expect = 4.8, Method: Composition-based stats. Identities = 17/81 (20%), Positives = 30/81 (37%), Gaps = 9/81 (11%) Query: 4 AALQVYGGDEVSAVVIDPGSYTTNIG--YSGSDFPQSILPSVYGKYTADEGNKKIFSEQS 61 A L +Y + +V+D G T++ Y+G P +IL D + + Sbjct: 138 AVLSLYSSGRTTGIVLDSGDGVTHVVPIYAGFSLPHAIL-------RIDLAGRDLTDYLM 190 Query: 62 IGIPRKDYELKPIIENGLVID 82 + + Y E +V D Sbjct: 191 KILSERGYSFSTTAEREIVRD 211 >1C0F-A nrPDB Length = 368 Score = 366 bits (940), Expect = e-102, Method: Composition-based stats. Identities = 77/285 (27%), Positives = 119/285 (41%), Gaps = 29/285 (10%) Query: 11 GDEVSAVVIDPGSYTTNIGYSGSDFPQSILPSVYGKYTADEGNKKIFSEQSIGIPRKDYE 70 G++V A+VID GS G++G D P+++ PS+ G+ K + R Sbjct: 2 GEDVQALVIDNGSGMCKAGFAGDDAPRAVFPSIVGR--PRHTGKDSYVGDEAQSKRGILT 59 Query: 71 LKPIIENGLVIDWDTAQEQWQWALQNELYLNSNSGIPALLTEPVWNSTENRKKSLEVLLE 130 LK IE+G+V +WD ++ W NEL + P LLTE N NR+K +++ E Sbjct: 60 LKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEH-PVLLTEAPLNPKANREKMTQIMFE 118 Query: 131 GMQFEACYLAPTSTCVSFAAGRPNCLVVDIGHDTCSVSPIVDGMTLSKSTRRNFIAGKFI 190 A Y+A + +A+GR +V+D G PI +G L + R +AG+ + Sbjct: 119 TFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVSHTVPIYEGYALPHAILRLDLAGRDL 178 Query: 191 NHLIKKALEPKEIIPLFAIKQRKPEFIKKTFDYEVDKSLYDYANNRGFFQECKETLCHIC 250 + K L +R F R ++ KE L ++ Sbjct: 179 TDYMMKIL-----------TERGYSFTTTA--------------EREIVRDIKEKLAYVA 213 Query: 251 PTKTLEETKTELSSTAKRSIESPWNEEIVFDNETRYGFAEELFLP 295 E SS ++S E P + I NE R+ E LF P Sbjct: 214 LDFEAEMQTAASSSALEKSYELPDGQVITIGNE-RFRCPEALFQP 257 Score = 205 bits (520), Expect = 5e-53, Method: Composition-based stats. Identities = 57/155 (36%), Positives = 82/155 (52%), Gaps = 11/155 (7%) Query: 342 EKEQEAVSKST-------SPAANSADTPNETGKRPLEEEKPPKENNELIGLADLVYSSIM 394 E E + + S+ P NE + P +P E G+ + Y+SIM Sbjct: 217 EAEMQTAASSSALEKSYELPDGQVITIGNERFRCPEALFQPSFLGMESAGIHETTYNSIM 276 Query: 395 SSDVDLRATLAHNVVLTGGTSSIPGLSDRLMTELNKILPS-LKFRILTTGHTIERQYQSW 453 DVD+R L NVVL+GGT+ PG++DR+ EL + PS +K +I+ ER+Y W Sbjct: 277 KCDVDIRKDLYGNVVLSGGTTMFPGIADRMNKELTALAPSTMKIKIIAPP---ERKYSVW 333 Query: 454 LGGSILTSLGTFHQLWVGKKEYEEVGVERLLNDRF 488 +GGSIL SL TF Q+W+ K+EY+E G + F Sbjct: 334 IGGSILASLSTFQQMWISKEEYDESGPSIVHRKCF 368 >5MVV-A nrPDB Length = 378 Score = 366 bits (938), Expect = e-101, Method: Composition-based stats. Identities = 76/292 (26%), Positives = 119/292 (40%), Gaps = 32/292 (10%) Query: 9 YGGDEVSAVVIDPGSYTTNIGYSGSDFPQSILPSVYGK-----YTADEGNKKIFSEQSIG 63 G ++V A+V+D GS G +G D P+S+ PS+ G+ K F Sbjct: 3 MGEEDVQALVVDNGSGNVKAGVAGDDAPRSVFPSIVGRPKNPGIMVGMEEKDAFVGDEAQ 62 Query: 64 IPRKDYELKPIIENGLVIDWDTAQEQWQWALQNELYLNSNSGIPALLTEPVWNSTENRKK 123 R LK IE+G+V +WD ++ W NEL P LLTE N NR++ Sbjct: 63 TKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRAAPEEH-PVLLTEAPLNPKGNRER 121 Query: 124 SLEVLLEGMQFEACYLAPTSTCVSFAAGRPNCLVVDIGHDTCSVSPIVDGMTLSKSTRRN 183 +++ E A Y+A + +++GR +V+D G PI +G L + R Sbjct: 122 MTQIMFESFNVPAMYVAIQAVLSLYSSGRTTGIVLDSGDGVSHTVPIYEGYALPHAIMRL 181 Query: 184 FIAGKFINHLIKKALEPKEIIPLFAIKQRKPEFIKKTFDYEVDKSLYDYANNRGFFQECK 243 +AG+ + + K L + + + + ++ K Sbjct: 182 DLAGRDLTEYLMKILHER-------------------------GYGFSTSAEKEIVRDIK 216 Query: 244 ETLCHICPTKTLEETKTELSSTAKRSIESPWNEEIVFDNETRYGFAEELFLP 295 E LC+I E +E SS ++S E P I NE R+ E LF P Sbjct: 217 EKLCYIALNFDEEMKTSEQSSDIEKSYELPDGNIITVGNE-RFRCPEALFQP 267 Score = 199 bits (506), Expect = 2e-51, Method: Composition-based stats. Identities = 50/150 (33%), Positives = 78/150 (52%), Gaps = 4/150 (2%) Query: 340 TEEKEQEAVSKSTSPAANSADTPNETGKRPLEEEKPPKENNELIGLADLVYSSIMSSDVD 399 T E+ + P N NE + P +P E G+ ++SI DVD Sbjct: 232 TSEQSSDIEKSYELPDGNIITVGNERFRCPEALFQPSFLGKEAAGIHTTTFNSIKKCDVD 291 Query: 400 LRATLAHNVVLTGGTSSIPGLSDRLMTELNKILPS-LKFRILTTGHTIERQYQSWLGGSI 458 +R L N+VL+GGT+ G+ +RL ++ + PS +K +++ ER+Y W+GGSI Sbjct: 292 IRKDLYGNIVLSGGTTMYEGIGERLTRDITTLAPSTMKIKVVAPP---ERKYSVWIGGSI 348 Query: 459 LTSLGTFHQLWVGKKEYEEVGVERLLNDRF 488 L+SL TF Q+W+ K+EY+E G + F Sbjct: 349 LSSLSTFQQMWITKEEYDESGPSIVHRKCF 378 >4PL7-A nrPDB Length = 440 Score = 365 bits (936), Expect = e-101, Method: Composition-based stats. Identities = 80/290 (27%), Positives = 124/290 (42%), Gaps = 32/290 (11%) Query: 11 GDEVSAVVIDPGSYTTNIGYSGSDFPQSILPSVYGK-----YTADEGNKKIFSEQSIGIP 65 G++V+A+VID GS GY+G D P ++ PSV G+ G K F Sbjct: 2 GEDVAALVIDNGSGMCKAGYAGDDAPHTVFPSVVGRPRHQGVMVGMGQKDSFVGDEAQSK 61 Query: 66 RKDYELKPIIENGLVIDWDTAQEQWQWALQNELYLNSNSGIPALLTEPVWNSTENRKKSL 125 R L+ IE+G+V +WD ++ W NEL L P LLTE N NR+K Sbjct: 62 RGILTLRYPIEHGIVTNWDDMEKIWHHTFYNELRLAPEEH-PVLLTEAPMNPKSNREKMT 120 Query: 126 EVLLEGMQFEACYLAPTSTCVSFAAGRPNCLVVDIGHDTCSVSPIVDGMTLSKSTRRNFI 185 +++ E A Y++ + +A+GR +V+D G V PI G +L + R + Sbjct: 121 QIMFETFNVPAFYVSIQAVLSLYASGRTTGIVLDSGDGVTHVVPIYAGFSLPHAILRIDL 180 Query: 186 AGKFINHLIKKALEPKEIIPLFAIKQRKPEFIKKTFDYEVDKSLYDYANNRGFFQECKET 245 AG+ + + K L + + + R ++ KE Sbjct: 181 AGRDLTDYLMKILSER-------------------------GYTFSTSAEREIVRDIKEK 215 Query: 246 LCHICPTKTLEETKTELSSTAKRSIESPWNEEIVFDNETRYGFAEELFLP 295 LC++ E + SS+ ++S E P + I NE R+ E LF P Sbjct: 216 LCYVALDFDQELQTSSQSSSIEKSYELPDGQVITIGNE-RFRAPEALFHP 264 Score = 193 bits (491), Expect = 1e-49, Method: Composition-based stats. Identities = 52/140 (37%), Positives = 74/140 (52%), Gaps = 4/140 (2%) Query: 350 KSTSPAANSADTPNETGKRPLEEEKPPKENNELIGLADLVYSSIMSSDVDLRATLAHNVV 409 P NE + P P E G+ Y+SIM DVD+R L N+V Sbjct: 239 SYELPDGQVITIGNERFRAPEALFHPSVLGLEASGIDQTTYNSIMKCDVDVRKELYSNIV 298 Query: 410 LTGGTSSIPGLSDRLMTELNKILP-SLKFRILTTGHTIERQYQSWLGGSILTSLGTFHQL 468 ++GGT+ PG+++R+ EL + P S+K +I ER+Y W+GGSIL SLGTF Q+ Sbjct: 299 MSGGTTMFPGIAERMQKELTALAPSSMKVKISAPP---ERKYSVWIGGSILASLGTFQQM 355 Query: 469 WVGKKEYEEVGVERLLNDRF 488 W+ K+EY+E G + F Sbjct: 356 WISKQEYDESGPSIVHLKCF 375 Score = 29.1 bits (63), Expect = 4.8, Method: Composition-based stats. Identities = 17/81 (20%), Positives = 30/81 (37%), Gaps = 9/81 (11%) Query: 4 AALQVYGGDEVSAVVIDPGSYTTNIG--YSGSDFPQSILPSVYGKYTADEGNKKIFSEQS 61 A L +Y + +V+D G T++ Y+G P +IL D + + Sbjct: 138 AVLSLYASGRTTGIVLDSGDGVTHVVPIYAGFSLPHAIL-------RIDLAGRDLTDYLM 190 Query: 62 IGIPRKDYELKPIIENGLVID 82 + + Y E +V D Sbjct: 191 KILSERGYTFSTSAEREIVRD 211 >3MN5-A nrPDB Length = 359 Score = 361 bits (927), Expect = e-100, Method: Composition-based stats. Identities = 75/285 (26%), Positives = 118/285 (41%), Gaps = 38/285 (13%) Query: 11 GDEVSAVVIDPGSYTTNIGYSGSDFPQSILPSVYGKYTADEGNKKIFSEQSIGIPRKDYE 70 DE +A+V D GS G++G D P+++ PS+ G+ R Sbjct: 2 EDETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGR-----------VGDEAQSKRGILT 50 Query: 71 LKPIIENGLVIDWDTAQEQWQWALQNELYLNSNSGIPALLTEPVWNSTENRKKSLEVLLE 130 LK IE+G++ +WD ++ W NEL + P LLTE N NR+K +++ E Sbjct: 51 LKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEH-PTLLTEAPLNPKANREKMTQIMFE 109 Query: 131 GMQFEACYLAPTSTCVSFAAGRPNCLVVDIGHDTCSVSPIVDGMTLSKSTRRNFIAGKFI 190 A Y+A + +A+GR +V+D G PI +G L + R +AG+ + Sbjct: 110 TFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDL 169 Query: 191 NHLIKKALEPKEIIPLFAIKQRKPEFIKKTFDYEVDKSLYDYANNRGFFQECKETLCHIC 250 + K L +R F+ R ++ KE LC++ Sbjct: 170 TDYLMKIL-----------TERGYSFVTTA--------------EREIVRDIKEKLCYVA 204 Query: 251 PTKTLEETKTELSSTAKRSIESPWNEEIVFDNETRYGFAEELFLP 295 E SS+ ++S E P + I NE R+ E LF P Sbjct: 205 LDFENEMATAASSSSLEKSYELPDGQVITIGNE-RFRCPETLFQP 248 Score = 202 bits (514), Expect = 2e-52, Method: Composition-based stats. Identities = 54/155 (34%), Positives = 81/155 (52%), Gaps = 11/155 (7%) Query: 342 EKEQEAVSKSTS-------PAANSADTPNETGKRPLEEEKPPKENNELIGLADLVYSSIM 394 E E + S+S P NE + P +P E G+ + Y+SIM Sbjct: 208 ENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIM 267 Query: 395 SSDVDLRATLAHNVVLTGGTSSIPGLSDRLMTELNKILPS-LKFRILTTGHTIERQYQSW 453 D+D+R L N V++GGT+ PG++DR+ E+ + PS +K +I+ ER+Y W Sbjct: 268 KCDIDIRKDLYANNVMSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPP---ERKYSVW 324 Query: 454 LGGSILTSLGTFHQLWVGKKEYEEVGVERLLNDRF 488 +GGSIL SL TF Q+W+ K+EY+E G + F Sbjct: 325 IGGSILASLSTFQQMWITKQEYDEAGPSIVHRKCF 359 >4CBX-A nrPDB Length = 378 Score = 331 bits (849), Expect = 4e-91, Method: Composition-based stats. Identities = 71/290 (24%), Positives = 115/290 (39%), Gaps = 33/290 (11%) Query: 12 DEVSAVVIDPGSYTTNIGYSGSDFPQSILPSVYG-----KYTADEGNKKIFSEQSIGIPR 66 +E A+V+D GS G +G D P+ + PS+ G K+ + R Sbjct: 5 EESIALVVDNGSGMVKSGLAGDDAPKCVFPSIIGIPKMPNIMVGMEQKECYVGDEAQNKR 64 Query: 67 KDYELKPIIENGLVIDWDTAQEQWQWALQNELYLNSNSGIPALLTEPVWNSTENRKKSLE 126 LK IE+G+V +WD ++ W+ NEL ++ P LLTE N NR+K + Sbjct: 65 GILTLKYPIEHGIVTNWDDMEKIWRHTFFNELRVSPEEH-PVLLTEAPLNPKTNREKMTQ 123 Query: 127 VLLEGMQFEACYLAPTSTCVSFAAGRPNCLVVDIGHDTCSVSPIVDGMTLSKSTRRNFIA 186 ++ E A Y++ + +A+GR +V+D G PI +G L + R +A Sbjct: 124 IMFESFDVPAMYVSIQAILSLYASGRTTGIVLDSGDGVTHTVPIYEGYVLPHAINRTDMA 183 Query: 187 GKFINHLIKKALEPKEIIPLFAIKQRKPEFIKKTFDYEVDKSLYDYANNRGFFQECKETL 246 G+ + + + K + + R ++ KE L Sbjct: 184 GRDLTYYMMKLFTER-------------------------GYTFTTTAEREIVRDIKEKL 218 Query: 247 CHICPTKTLEETKTELSSTAKRS-IESPWNEEIVFDNETRYGFAEELFLP 295 C+I E K+E + E P I +E R+ E LF P Sbjct: 219 CYIALDYDEELKKSEERTEEVEEMYELPDGNLITVGSE-RFRCPEALFNP 267 Score = 187 bits (474), Expect = 1e-47, Method: Composition-based stats. Identities = 52/156 (33%), Positives = 83/156 (53%), Gaps = 4/156 (2%) Query: 334 DKKVTPTEEKEQEAVSKSTSPAANSADTPNETGKRPLEEEKPPKENNELIGLADLVYSSI 393 D+++ +EE+ +E P N +E + P P E GL Y SI Sbjct: 226 DEELKKSEERTEEVEEMYELPDGNLITVGSERFRCPEALFNPSLIGRECPGLHITAYQSI 285 Query: 394 MSSDVDLRATLAHNVVLTGGTSSIPGLSDRLMTELNKI-LPSLKFRILTTGHTIERQYQS 452 M D+D+R L +N+VL+GGT+ + +RL E+ + PS+K +++ ER+Y Sbjct: 286 MKCDIDIRKELYNNIVLSGGTTMYNYIGERLTNEMTSLAPPSMKIKVIAPP---ERKYSV 342 Query: 453 WLGGSILTSLGTFHQLWVGKKEYEEVGVERLLNDRF 488 W+GGSIL+SL TF ++W+ K+EY+E G + F Sbjct: 343 WIGGSILSSLSTFQKMWITKEEYDESGPSIVHRKCF 378 >3ULE-B nrPDB Length = 394 Score = 309 bits (790), Expect = 2e-84, Method: Composition-based stats. Identities = 101/476 (21%), Positives = 162/476 (34%), Gaps = 105/476 (22%) Query: 16 AVVIDPGSYTTNIGYSGSDFPQSILPSVYGK----YTADEGN---KKIFSEQSIGIPRKD 68 VV D G+ GY+GS+FP+ I P++ G+ T GN K + R Sbjct: 8 VVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPIIRSTTKVGNIEIKDLMVGDEASELRSM 67 Query: 69 YELKPIIENGLVIDWDTAQEQWQWALQNELYLNSNSGIPALLTEPVWNSTENRKKSLEVL 128 E+ +ENG+V +WD + W + E LLTEP N T+NR+K +EV+ Sbjct: 68 LEVNYPMENGIVRNWDDMKHLWDYTFGPEKLNIDTRNCKILLTEPPMNPTKNREKIVEVM 127 Query: 129 LEGMQFEACYLAPTSTCVSFAAGRPNCLVVDIGHDTCSVSPIVDGMTLSKSTRRNFIAGK 188 E QF Y+A + +A G +VVD G + P+ +G +L TRR IAG+ Sbjct: 128 FETYQFSGVYVAIQAVLTLYAQGLLTGVVVDSGDGVTHICPVYEGFSLPHLTRRLDIAGR 187 Query: 189 FINHLIKKALEPKEIIPLFAIKQRKPEFIKKTFDYEVDKSLYDYANNRGFFQECKETLCH 248 I + K L + ++++ + + KE LC+ Sbjct: 188 DITRYLIKLLLLR-------------------------GYAFNHSADFETVRMIKEKLCY 222 Query: 249 ICPTKTLEETKTELSSTAKRSIESPWNEEIVFDNETRYGFAEELFLPKEDDIPANWPRSN 308 + E+ ++ S P I R+ E LF P ++ Sbjct: 223 VGYNIEQEQKLALETTVLVESYTLPDGRIIKVG-GERFEAPEALFQPHLINV------EG 275 Query: 309 SGVVKTWRNDYVPLKRTKPSGVNKSDKKVTPTEEKEQEAVSKSTSPAANSADTPNETGKR 368 GV + N + + + K + S P Sbjct: 276 VGVAELLFN------------------TIQAADIDTRSEFYKHIVLSGGSTMYPG----- 312 Query: 369 PLEEEKPPKENNELIGLADLVYSSIMSSDVDLRATLAHNVVLTGGTSSIPGLSDRLMTEL 428 P + EL L VL G + R+ Sbjct: 313 -----LPSRLEREL-------------------KQLYLERVLKGDVEKLSKFKIRIE--- 345 Query: 429 NKILPSLKFRILTTGHTIERQYQSWLGGSILTS-LGTFHQLWVGKKEYEEVGVERL 483 R++ +LGG++L + W+ ++EY+E GV L Sbjct: 346 ---------------DPPRRKHMVFLGGAVLADIMKDKDNFWMTRQEYQEKGVRVL 386 >3DWL-A nrPDB Length = 427 Score = 300 bits (768), Expect = 9e-82, Method: Composition-based stats. Identities = 96/507 (18%), Positives = 156/507 (30%), Gaps = 133/507 (26%) Query: 17 VVIDPGSYTTNIGYSGSDFPQSILPSVYG----------------KYTADEGNKKIFSE- 59 +++D G+ + +GY+G+D P + P+V Y A +G+ + S+ Sbjct: 8 IIMDNGTGYSKLGYAGNDAPSYVFPTVIATRSAGASSGPAVSSKPSYMASKGSGHLSSKR 67 Query: 60 -----------QSIGIPRKDYELKPIIENGLVIDWDTAQEQWQWALQNELYLNSNSGIPA 108 ++ Y L I +G + +WD + WQ +L L Sbjct: 68 ATEDLDFFIGNDALKKASAGYSLDYPIRHGQIENWDHMERFWQQSLFKYLRCEPEDHY-F 126 Query: 109 LLTEPVWNSTENRKKSLEVLLEGMQFEACYLAPTS--------TCVSFAAGRPNCLVVDI 160 LLTEP N ENR+ + E++ E Y+A + T VVD Sbjct: 127 LLTEPPLNPPENRENTAEIMFESFNCAGLYIAVQAVLALAASWTSSKVTDRSLTGTVVDS 186 Query: 161 GHDTCSVSPIVDGMTLSKSTRRNFIAGKFINHLIKKALEPKEIIPLFAIKQRKPEFIKKT 220 G + P+ +G + S + +AG+ + + ++ L + Sbjct: 187 GDGVTHIIPVAEGYVIGSSIKTMPLAGRDVTYFVQSLLRDRN------------------ 228 Query: 221 FDYEVDKSLYDYANNRGFFQECKETLCHICPT--KTLEETKTELSSTAKRSIESPWNEEI 278 E D SL KE C++CP K E K + ES Sbjct: 229 ---EPDSSLKTAER-------IKEECCYVCPDIVKEFSRFDREPDRYLKYASESITGHST 278 Query: 279 VFDNETRYGFAEELFLPKEDDIPANWPRSNSGVVKTWRNDYVPLKRTKPSGVNKSDKKVT 338 D A E+F E +D+ +T Sbjct: 279 TIDVGFERFLAPEIFFNPE----------------IASSDF-----------------LT 305 Query: 339 PTEEKEQEAVSKSTSPAANSADTPNETGKRPLEEEKPPKENNELIGLADLVYSSIMSSDV 398 P E V S P++ K +N L G + L + Sbjct: 306 PLPELVDNVVQSS-----------------PIDVRKGLYKNIVLSGGSTLFKNFGNRLQR 348 Query: 399 DLRATLAHNVVLTGGTSSIPGLSDRLMTELNKILPSLKFRILTTGHTIERQYQSWLGGSI 458 DL+ + + R +E+ S + H +R W GGS+ Sbjct: 349 DLKRIVDERI-------------HR--SEMLSGAKSGGVDVNVISHKRQRN-AVWFGGSL 392 Query: 459 LTSLGTFHQLWVGKKEYEEVGVERLLN 485 L F K +YEE G Sbjct: 393 LAQTPEFGSYCHTKADYEEYGASIARR 419 >6F3A-A nrPDB Length = 376 Score = 283 bits (723), Expect = 1e-76, Method: Composition-based stats. Identities = 63/286 (22%), Positives = 106/286 (37%), Gaps = 35/286 (12%) Query: 15 SAVVIDPGSYTTNIGYSGSDFPQSILPSVYGK-----YTADEGNKKIFSEQSIGIPRKDY 69 VVID GS G++G P+ P+ G+ A IF R Sbjct: 10 QPVVIDNGSGVIKAGFAGDQIPKYCFPNYVGRPKHVRVMAGALEGDIFIGPKAEEHRGLL 69 Query: 70 ELKPIIENGLVIDWDTAQEQWQWALQNELYLNSNSGIPALLTEPVWNSTENRKKSLEVLL 129 ++ +E+G+V DW+ + WQ+ + + P LLTE N +NR+++ EV Sbjct: 70 SIRYPMEHGIVKDWNDMERIWQYVYSKDQLQTFSEEHPVLLTEAPLNPRKNRERAAEVFF 129 Query: 130 EGMQFEACYLAPTSTCVSFAAGRPNCLVVDIGHDTCSVSPIVDGMTLSKSTRRNFIAGKF 189 E A +++ + +A GR +V+D G PI +G + S R IAG+ Sbjct: 130 ETFNVPALFISMQAVLSLYATGRTTGVVLDSGDGVTHAVPIYEGFAMPHSIMRIDIAGRD 189 Query: 190 INHLIKKALEPKEIIPLFAIKQRKPEFIKKTFDYEVDKSLYDYANNRGFFQECKETLCHI 249 ++ ++ L + + ++ + KE C++ Sbjct: 190 VSRFLRLYLRK-------------------------EGYDFHSSSEFEIVKAIKERACYL 224 Query: 250 CPTKTLEETKTELSSTAKRSIESPWNEEIVFDNETRYGFAEELFLP 295 +ET T K P I +R+ E LF P Sbjct: 225 SINPQKDETLE----TEKAQYYLPDGSTIEIG-PSRFRAPELLFRP 265 Score = 176 bits (445), Expect = 3e-44, Method: Composition-based stats. Identities = 53/155 (34%), Positives = 84/155 (54%), Gaps = 5/155 (3%) Query: 336 KVTPTEEKEQEA-VSKSTSPAANSADTPNETGKRPLEEEKPPKENNELIGLADLVYSSIM 394 + P +++ E ++ P ++ + + P +P E G+ +++ +I Sbjct: 225 SINPQKDETLETEKAQYYLPDGSTIEIGPSRFRAPELLFRPDLIGEESEGIHEVLVFAIQ 284 Query: 395 SSDVDLRATLAHNVVLTGGTSSIPGLSDRLMTELNKILPS-LKFRILTTGHTIERQYQSW 453 SD+DLR TL N+VL+GG++ G DRL++E+ K+ P +K RI ER Y +W Sbjct: 285 KSDMDLRRTLFSNIVLSGGSTLFKGFGDRLLSEVKKLAPKDVKIRISAPQ---ERLYSTW 341 Query: 454 LGGSILTSLGTFHQLWVGKKEYEEVGVERLLNDRF 488 +GGSIL SL TF ++WV KKEYEE G + F Sbjct: 342 IGGSILASLDTFKKMWVSKKEYEEDGARSIHRKTF 376 >1K8K-A nrPDB Length = 418 Score = 251 bits (640), Expect = 6e-67, Method: Composition-based stats. Identities = 73/341 (21%), Positives = 124/341 (36%), Gaps = 52/341 (15%) Query: 12 DEVSAVVIDPGSYTTNIGYSGSDFPQSILPSVYG----KYTADEGNKKI--------FSE 59 + A V+D G+ T +GY+G+ PQ I+PS D+ +++ F Sbjct: 3 GRLPACVVDCGTGYTKLGYAGNTEPQFIIPSCIAIKESAKVGDQAQRRVMKGVDDLDFFI 62 Query: 60 QSIGIPRKDYELKPIIENGLVIDWDTAQEQWQWALQNELYLNSNSGIPALLTEPVWNSTE 119 I + Y K I +G+V DWD + + + L LLTEP N+ E Sbjct: 63 GDEAIEKPTYATKWPIRHGIVEDWDLMERFMEQVIFKYLRAEPEDHY-FLLTEPPLNTPE 121 Query: 120 NRKKSLEVLLEGMQFEACYLAPTS--------TCVSFAAGRPNCLVVDIGHDTCSVSPIV 171 NR+ + E++ E Y+A + T V+D G V P+ Sbjct: 122 NREYTAEIMFESFNVPGLYIAVQAVLALAASWTSRQVGERTLTGTVIDSGDGVTHVIPVA 181 Query: 172 DGMTLSKSTRRNFIAGKFINHLIKKALEPKEIIPLFAIKQRKPEFIKKTFDYEVDKSLYD 231 +G + + IAG+ I + I++ L +E+ ++SL Sbjct: 182 EGYVIGSCIKHIPIAGRDITYFIQQLLRDREV------------------GIPPEQSLET 223 Query: 232 YANNRGFFQECKETLCHICPT--KTLEETKTELSSTAKRS--IESPWNEEIVFDNETRYG 287 + KE ++CP K + T+ S K+ I + +E D Sbjct: 224 A-------KAVKERYSYVCPDLVKEFNKYDTDGSKWIKQYTGINAISKKEFSIDVGYERF 276 Query: 288 FAEELFLPKEDDIPANWPRSNSGVVKTWRNDYVPLKRTKPS 328 E+F E P + V + +N P+ +P Sbjct: 277 LGPEIFFHPEFANPDFTQPISEVVDEVIQN--CPIDVRRPL 315 Score = 132 bits (332), Expect = 3e-31, Method: Composition-based stats. Identities = 49/208 (23%), Positives = 83/208 (39%), Gaps = 22/208 (10%) Query: 288 FAEELFLPKEDDIPANWPRSNSGVVKTWRNDYVPLKRTKPSGVNKSDKKVTPTEEKEQEA 347 F ++L +E IP P + K + Y + NK D ++ +Q Sbjct: 203 FIQQLLRDREVGIP---PEQSLETAKAVKERYSYVCPDLVKEFNKYDT--DGSKWIKQYT 257 Query: 348 VSKSTSPAANSADTPNETGKRPLEEEKPPKENNELI-GLADLVYSSIMSSDVDLRATLAH 406 + S S D E P P N + ++++V I + +D+R L Sbjct: 258 GINAISKKEFSIDVGYERFLGPEIFFHPEFANPDFTQPISEVVDEVIQNCPIDVRRPLYK 317 Query: 407 NVVLTGGTSSIPGLSDRLMTELNKILPSL---------------KFRILTTGHTIERQYQ 451 N+VL+GG++ RL +L + + + + H ++R Y Sbjct: 318 NIVLSGGSTMFRDFGRRLQRDLKRTVDARLKLSEELSGGRLKPKPIDVQVITHHMQR-YA 376 Query: 452 SWLGGSILTSLGTFHQLWVGKKEYEEVG 479 W GGS+L S F+Q+ KK+YEE+G Sbjct: 377 VWFGGSMLASTPEFYQVCHTKKDYEEIG 404 >5NW4-X nrPDB Length = 417 Score = 241 bits (615), Expect = 4e-64, Method: Composition-based stats. Identities = 94/480 (19%), Positives = 158/480 (32%), Gaps = 116/480 (24%) Query: 11 GDEVSAVVIDPGSYTTNIGYSGSDFPQSILPSVYGKYTADEGNKKIFSEQSIGIPRKDYE 70 G E +AVVID G T G++G P+ I+PSV K G+P+ Sbjct: 10 GGEKTAVVIDLGEAFTKCGFAGETGPRCIIPSVIKK---------------AGMPKPIKV 54 Query: 71 LKPIIENGLVIDWDTAQEQWQWALQNELYLNSNSGIPALLTEPVWNSTENRKKSLEVLLE 130 ++ I + + +E L +N ++ E V + R+ VL + Sbjct: 55 VQYNINTEELYSY--LKEFIHILYFRHLLVNPRDRR-VVVIESVLCPSHFRETLTRVLFK 111 Query: 131 GMQFEACYLAPTSTCVSFAAGRPNCLVVDIGHDTCSVSPIVDGMTLSKSTRRNFIAGKFI 190 + + LAP+ G + +V+D G+ V PI +G+ + + GK + Sbjct: 112 YFEVPSVLLAPSHLMALLTLGINSAMVLDCGYRESLVLPIYEGIPVLNCWGALPLGGKAL 171 Query: 191 NHLIKKALEPKEIIPLFAIKQRKPEFIKKTFDYEVDKSLYDYANNRGFFQECKETLCHIC 250 + ++ L + + A K+ + + + L ++ K C + Sbjct: 172 HKELETQLLEQCTVDTGAAKE---QSLPSVMGSIPEGVL----------EDIKVRTCFV- 217 Query: 251 PTKTLEETKTELSSTAKRSIESPWNEEIVFDNETRYGFAEELFLPKEDDIPANWPRSNSG 310 + L A + D T P D Sbjct: 218 -----SDLTRGLKIQAAKF---------NIDGNTERPSP-----PPNVDY---------- 248 Query: 311 VVKTWRNDYVPLKRTKPSGVNKSDKKVTPTEEKEQEAVSKSTSPAANSADTPNETGKRPL 370 PL K V + Sbjct: 249 ----------PLDGEKILHV------------------------------LGSIRDSVVE 268 Query: 371 EEEKPPKENNELIGLADLVYSSIMSSDVDLRATLAHNVVLTGGTSSIPGLSDRLMTEL-- 428 + ++NE +A L+ S+M +D R LA N+V+ GGTS +PG RL+ E+ Sbjct: 269 ILFE---QDNEEKSVATLILDSLMQCPIDTRKQLAENLVIIGGTSMLPGFLHRLLAEIRY 325 Query: 429 -------NKILPSLKFRILTTGHTIERQYQSWLGGSILTSL-GTFHQLWVGKKEYEEVGV 480 K L + FRI T + +WLGG+I +L V K+ Y + G Sbjct: 326 LVEKPKYKKTLGTKTFRIHTP--PAKANCVAWLGGAIFGALQDILGSRSVSKEYYNQTGR 383 >6HTS-H nrPDB Length = 607 Score = 235 bits (598), Expect = 4e-62, Method: Composition-based stats. Identities = 98/551 (17%), Positives = 185/551 (33%), Gaps = 102/551 (18%) Query: 17 VVIDPGSYTTNIGYS--GSD---FPQSILPSVYGKYTADEGNKKIFSEQSIGIPRKDYE- 70 +V+D GS+ G++ G D P+ +V G + S +G E Sbjct: 33 LVLDNGSFQVRAGWACPGQDPGPEPRLQFRAVC---ARGRGGARGASGPQVGNALGSLEP 89 Query: 71 ----LKPIIENGLVIDWDTAQEQWQWALQNELYLNSN--SGIPALLTEPVWNSTENRKKS 124 L+ + + ++ + + ++ Q+ L ++S P +LTE V N +R+ Sbjct: 90 LRWMLRSPFDRNVPVNLELQELLLDYSFQH-LGVSSQGCVDHPIVLTEAVCNPLYSRQMM 148 Query: 125 LEVLLEGMQFEACYLAPTSTCVSF----AAGRPNCLVVDIGHDTCSVSPIVDGMTLSKST 180 E+L E S + + L++ G+ V PI++G +K+ Sbjct: 149 SELLFECYGIPKVAYGIDSLFSFYHNKPKNSMCSGLIISSGYQCTHVLPILEGRLDAKNC 208 Query: 181 RRNFIAGKFINHLIKKALEPKEIIPLFAIKQRKPEFIKKTFDYEVDKSLYDY-------- 232 +R + G +++ L+ K L AI + E I Y + + + Sbjct: 209 KRINLGGSQAAGYLQRLLQLKYPGHLAAITLSRMEEILHEHSYIAEDYVEELHKWRCPDY 268 Query: 233 ---------------------------------------------ANNRGFFQECKETLC 247 QE + L Sbjct: 269 YENNVHKMQLPFSSKLLGSTLTSEEKQERRQQQLRRLQELNARRREEKLQLDQERLDRLL 328 Query: 248 HICPTKTLEETKTELSSTAKRSIESPWN-----EEIVFDNETRYGFAEELFLPKEDDIPA 302 ++ + + + +++SP +++ E + + E D+ Sbjct: 329 YVQELLEDGQMDQFHKALIELNMDSPEELQSYIQKLSIAVEQAKQKILQAEVNLEVDVVD 388 Query: 303 NWPRSNSGVVKTWR-------NDYVPLKRTKPSGVNKSDKKVTPTEEKEQEAVSKSTSPA 355 + P + ND+ PL + GV K V P A Sbjct: 389 SKPETPDLEQLEPSLEDVESMNDFDPLFSEETPGVEKPVTTVQPV----------FNLAA 438 Query: 356 ANSADTPNETGKRPLEEEKPPKENNELIGLADLVYSSIMSSDVDLRATLAHNVVLTGGTS 415 + E + P +P E G+A+ + + D++ L NV LTGG + Sbjct: 439 YHQLFVGTERIRAPEIIFQPSLIGEEQAGIAETLQYILDRYPKDIQEMLVQNVFLTGGNT 498 Query: 416 SIPGLSDRLMTELNKILP-SLKFRILTTGHTIERQYQSWLGGS--ILTSLGTFHQLWVGK 472 PG+ R+ EL ++ P F++ + + +W G L L +++W+ + Sbjct: 499 MYPGMKARMEKELLEMRPFRSSFQVQLASNPV---LDAWYGARDWALNHLDD-NEVWITR 554 Query: 473 KEYEEVGVERL 483 KEYEE G E L Sbjct: 555 KEYEEKGGEYL 565 >4FO0-A nrPDB Length = 593 Score = 143 bits (360), Expect = 2e-34, Method: Composition-based stats. Identities = 70/425 (16%), Positives = 147/425 (34%), Gaps = 34/425 (8%) Query: 85 TAQEQWQWALQNELY--LNSNSGIPALLTEPVWNSTENRKKSLEVLLEGMQFEACYLAPT 142 + W A+Q L L +L P + ++ K+ + ++L M F + Sbjct: 176 DIEVIWSHAIQKYLEIPLKDLKYYRCILLIPDIYNKQHVKELVNMILMKMGFSGIVVHQE 235 Query: 143 STCVSFAAGRPNCLVVDIGHDTCSVSPIVDGMTLSKSTRRNFIAGKFIN---HLIKKA-- 197 S C ++ +G + +VD+G SV + DG++ + G ++ + + + Sbjct: 236 SVCATYGSGLSSTCIVDVGDQKTSVCCVEDGVSHRNTRLCLAYGGSDVSRCFYWLMQRAG 295 Query: 198 LEPKEIIPLFAIKQRKPEFIKKTFDYEVDKSLYDYANNRGFFQECKETLCHICPTKTLEE 257 +E + + +K+TF + +D+ + ++ + Sbjct: 296 FPYRECQLTNKMDCLLLQHLKETFCH-LDQDISGLQDHEFQIRHPDSP----ALLYQFRL 350 Query: 258 TKTELSSTAKRSI---ESPWNEEIVFDNETRYGFAEELFLPKEDDIPANWPRSNSGVVKT 314 +L + +++ G E+ P ++ K Sbjct: 351 GDEKLQAPMALFYPATFGIVGQKMTTLQHRSQGDPED---PHDEHYLLATQSKQEQSAKA 407 Query: 315 WRNDYVPLKRTKPSGVNKSDKKVTPTEEKEQEAVSKSTSPAANSADTPNETGKRPLEEEK 374 + K G + P QE S + N++ + Sbjct: 408 TADRKSASKPIGFEGDLRGQSSDLPERLHSQEV--DLGSAQGDGLMAGNDSEEALTALMS 465 Query: 375 P----PKENNELIGLADLVYSSIMSSDVD-LRATLAHNVVLTGGTSSIPGLSDRLMTE-L 428 + +GL + SI D + + ++++ GG + L L Sbjct: 466 RKTAISLFEGKALGLDKAILHSIDCCSSDDTKKKMYSSILVVGGGLMFHKAQEFLQHRIL 525 Query: 429 NKILPSLKFRILTTGHTIER------QYQSWLGGSILTSLGTFHQLWVGKKEYEEVGVER 482 NK+ PS + RI+ I R + +W GG++L L T +LW+ ++E++ GV R Sbjct: 526 NKMPPSFR-RIIENVDVITRPKDMDPRLIAWKGGAVLACLDTTQELWIYQREWQRFGV-R 583 Query: 483 LLNDR 487 +L +R Sbjct: 584 MLRER 588 Score = 32.1 bits (71), Expect = 0.51, Method: Composition-based stats. Identities = 14/37 (37%), Positives = 18/37 (48%), Gaps = 1/37 (2%) Query: 17 VVIDPGSYTTNIGYSGSDFPQSILPSVYGKYTADEGN 53 +VI PGS T IG + P SI P V + +G Sbjct: 18 IVIHPGSTTLRIGRATDTLPASI-PHVIARRHKQQGQ 53 >6GEJ-R nrPDB Length = 438 Score = 125 bits (314), Expect = 3e-29, Method: Composition-based stats. Identities = 81/524 (15%), Positives = 155/524 (29%), Gaps = 141/524 (26%) Query: 13 EVSAVVIDPGSYTTNIGYSGSDFPQSILPSVYG-KYTADEGNKKIFSEQSIGIPRKDYEL 71 E +VID GSY G S + P L ++ K+ + I + + I Sbjct: 2 ETPPIVIDNGSYEIKFGPSTNKKPFRALNALAKDKFGTSYLSNHIKNIKDISS----ITF 57 Query: 72 KPIIENGLVIDWDTAQEQWQWALQNELYLNSNS-----GIPALLTEPVWNSTENRKKSLE 126 + E G + W+ W + L N + G + +E E K + + Sbjct: 58 RRPHELGQLTLWELESCIWDYCLFNPSEFDGFDLKEGKGHHLVASESCMTLPELSKHADQ 117 Query: 127 VLLEGMQFEACYLAPTSTCVSFA------AGRPNC------------------------- 155 V+ E +F++ + +P + V F + Sbjct: 118 VIFEEYEFDSLFKSPVAVFVPFTKSYKGEMRTISGKDEDIDIVRGNSDSTNSTSSESKNA 177 Query: 156 -----------LVVDIGHDTCSVSPIVDGMTLSKSTRRNFIAGKFINHLIKKALEPKEII 204 LV+D G + + P++ G+ K+ ++ I G+F+ L+K+ L + Sbjct: 178 QDSGSDYHDFQLVIDSGFNCTWIIPVLKGIPYYKAVKKLDIGGRFLTGLLKETLSFRH-- 235 Query: 205 PLFAIKQRKPEFIKKTFDYEVDKSLYDYANNRGFFQECKETLCHICPTKTLEETKTELSS 264 Y+ + KE + P + KT+ Sbjct: 236 -------------------------YNMMDETILVNNIKEQCLFVSPVSYFDSFKTKDKH 270 Query: 265 TAKRSIESPWNEEIVFDNETRYGFAEELFLPKEDDIPANWPRSNSGVVKTWRNDYVPLKR 324 + P + + P+++++P P Sbjct: 271 ALE--YVLPDFQTSFLG---------YVRNPRKENVPL------------------PE-- 299 Query: 325 TKPSGVNKSDKKVTPTEEKEQEAVSKSTSPAANSADTPNETGKRPLEEEKPPKENNELIG 384 A +E P P G Sbjct: 300 ------------------------------DAQIITLTDELFTIPETFFHPEISQITKPG 329 Query: 385 LADLVYSSIMSSDVDLRATLAHNVVLTGGTSSIPGLSDRLMTELNKILPSLKFRILTTGH 444 + + + S+ +R + N+V TGG ++P + RL EL + LP+ + + Sbjct: 330 IVEAILESLSMLPEIVRPLMVGNIVCTGGNFNLPNFAQRLAAELQRQLPT-DWTCHVSVP 388 Query: 445 TIERQYQSWLGGSILTSLGTFHQLWVGKKEYEEVGVERLLNDRF 488 + W S ++ + V ++EY E G + RF Sbjct: 389 EGDCALFGWEVMSQFAKTDSYRKARVTREEYYEHGPDWCTKHRF 432 >4AM6-A nrPDB Length = 655 Score = 77.6 bits (189), Expect = 1e-14, Method: Composition-based stats. Identities = 71/545 (13%), Positives = 143/545 (26%), Gaps = 146/545 (26%) Query: 30 YSGSDFPQSILPSVYGKYTADEGNKKIFSEQSIGIPRKDYELKPIIENGLVIDWDTAQEQ 89 Y GSD + + + K F S +K L + Sbjct: 158 YYGSDALRCVDEKFVIR--------KPFRGGSFN-------VKSPYYKSLAELISDVTKL 202 Query: 90 WQWALQNE-LYLNSNS--GIPALLTEPVWNSTENRKKSLEVLLEGMQFEACYLAPTSTCV 146 + AL +E L + +L P + + + VLL +QF+A + S Sbjct: 203 LEHALNSETLNVKPTKFNQYKVVLVIPDIFKKSHVETFIRVLLTELQFQAVAIIQESLAT 262 Query: 147 SFAAGRPNCL-VVDIGHDTCSVSPIVDGMTLSKSTRRNFIAGKFINHLIKKALEPKEIIP 205 + AG VV+IG ++ + +G L S G I L L Sbjct: 263 CYGAGISTSTCVVNIGAAETRIACVDEGTVLEHSAITLDYGGDDITRLFALFL------- 315 Query: 206 LFAIKQRKPEFIKKTFDYEVDKSLYDYANNRGFFQECKETLCHICPTKTLEETKTELSST 265 + +F + + + + F ++ + + Sbjct: 316 ------LQSDFPLQDWKIDSKHGWLLAERLKKNFTTFQDADVAVQL---YNFMNRSPNQP 366 Query: 266 AKRSIESPWNEEIVFDNETRYGFAEELFLPKEDDIPANWPRSNSGVVKTWRNDYVPLKRT 325 ++ ++E ++ LF P+ + NS + P R Sbjct: 367 TEKYEFKLFDEVML--------APLALFFPQIFKLIRTSSHKNSSLEFQL-----PESRD 413 Query: 326 KPSGVNKSDKKVTPTEEKEQEAVSKSTSPAANS-------ADTPNETGKRPLEEEK---- 374 + E + ++S+ S N N ++ Sbjct: 414 -----------LFTNELNDWNSLSQFESKEGNLYCDLNDDLKILNRILDAHNIIDQLQDK 462 Query: 375 PPKENNE--------LIGLADLVYSSIMSSDVDLRATLAHNVVLTGGTS----------- 415 P N + + ++ +++DV + N+++ GG+S Sbjct: 463 PENYGNTLKENFAPLEKAIVQSIANASITADVTRMNSFYSNILIVGGSSKIPALDFILTD 522 Query: 416 -------------SIPGLSDRLMTELNKI------LPS---------------------- 434 S P +L E+ + P Sbjct: 523 RINIWRPSLLSSASFPQFYKKLTKEIKDLEGHYVNAPDKTEDENKQILQAQIKEKIVEEL 582 Query: 435 ----------------LKFRILTTGHTIERQYQSWLGGSILTSLGTFHQLWVGKKEYEEV 478 I+ + W G S+L + +L++ +++ Sbjct: 583 EEQHQNIEHQNGNEHIFPVSIIPPPRDMNPALIIWKGASVLAQIKLVEELFITNSDWDVH 642 Query: 479 GVERL 483 G L Sbjct: 643 GSRIL 647 Score = 32.1 bits (71), Expect = 0.56, Method: Composition-based stats. Identities = 11/34 (32%), Positives = 18/34 (52%), Gaps = 1/34 (2%) Query: 12 DEVSAVVIDPGSYTTNIGYSGSDFPQSILPSVYG 45 D + +VI PGS + IG+ D P ++P+ Sbjct: 38 DPTATIVIHPGSNSIKIGFPKDDHP-VVVPNCVA 70 >4I6M-B nrPDB Length = 439 Score = 64.1 bits (154), Expect = 1e-10, Method: Composition-based stats. Identities = 42/215 (19%), Positives = 78/215 (36%), Gaps = 17/215 (7%) Query: 34 DFPQSILPSVYGKYTADEGNKKIFSEQSIGIPRKDYELKPIIENGLVIDWDTAQEQWQWA 93 P+ +P+ + T +G+ S EL I+NG +ID + + Sbjct: 31 TVPELEIPTQIYRTTRQDGSYTYHSTN----KDNKAELIKPIQNGEIIDISAFTQFLRLI 86 Query: 94 LQNEL----------YLNSNSGIPALLTEPVWNSTENRKKSLEVLLEGMQFEACYLAPTS 143 + L + S IP LL S + + + + E ++ P S Sbjct: 87 FVSILSDRANKNQDAFEAELSNIPLLLITHHSWSQSDLEIITQYVFESLEINNLIQLPAS 146 Query: 144 TCVSFAA-GRPNCLVVDIGHDTCSVSPIVDGMTLSKSTRRNFIAGKFINHLIKKALEPKE 202 +++ NC ++D+G + PIVD L + G+ IN +KK L + Sbjct: 147 LAATYSMISLQNCCIIDVGTHHTDIIPIVDYAQLDHLVSSIPMGGQSINDSLKKLLPQWD 206 Query: 203 IIPLFAIKQRKPEFIKKTFDYEVDKSLYDYANNRG 237 + ++ +K + D S +D+ N Sbjct: 207 DDQIESL--KKSPIFEVLSDDAKKLSSFDFGNENE 239 Score = 35.2 bits (79), Expect = 0.064, Method: Composition-based stats. Identities = 13/76 (17%), Positives = 28/76 (36%), Gaps = 8/76 (10%) Query: 355 AANSADTPNETGKRPLEEEKPPKENNELIGLADLVYSSIMSSDVDLRATLAHNVVLTGGT 414 N + + N + + + D++ + N+++ GGT Sbjct: 260 KGNEIKVGKQRFQG-----CNNLIKNISNRVGLTLDNI---DDINKAKAVWENIIIVGGT 311 Query: 415 SSIPGLSDRLMTELNK 430 +SI G + L+ +L K Sbjct: 312 TSISGFKEALLGQLLK 327 >3WEE-A nrPDB Length = 476 Score = 64.1 bits (154), Expect = 1e-10, Method: Composition-based stats. Identities = 42/215 (19%), Positives = 78/215 (36%), Gaps = 17/215 (7%) Query: 34 DFPQSILPSVYGKYTADEGNKKIFSEQSIGIPRKDYELKPIIENGLVIDWDTAQEQWQWA 93 P+ +P+ + T +G+ S EL I+NG +ID + + Sbjct: 40 TVPELEIPTQIYRTTRQDGSYTYHSTN----KDNKAELIKPIQNGEIIDISAFTQFLRLI 95 Query: 94 LQNEL----------YLNSNSGIPALLTEPVWNSTENRKKSLEVLLEGMQFEACYLAPTS 143 + L + S IP LL S + + + + E ++ P S Sbjct: 96 FVSILSDRANKNQDAFEAELSNIPLLLITHHSWSQSDLEIITQYVFESLEINNLIQLPAS 155 Query: 144 TCVSFAA-GRPNCLVVDIGHDTCSVSPIVDGMTLSKSTRRNFIAGKFINHLIKKALEPKE 202 +++ NC ++D+G + PIVD L + G+ IN +KK L + Sbjct: 156 LAATYSMISLQNCCIIDVGTHHTDIIPIVDYAQLDHLVSSIPMGGQSINDSLKKLLPQWD 215 Query: 203 IIPLFAIKQRKPEFIKKTFDYEVDKSLYDYANNRG 237 + ++ +K + D S +D+ N Sbjct: 216 DDQIESL--KKSPIFEVLSDDAKKLSSFDFGNENE 248 Score = 34.8 bits (78), Expect = 0.074, Method: Composition-based stats. Identities = 13/76 (17%), Positives = 28/76 (36%), Gaps = 8/76 (10%) Query: 355 AANSADTPNETGKRPLEEEKPPKENNELIGLADLVYSSIMSSDVDLRATLAHNVVLTGGT 414 N + + N + + + D++ + N+++ GGT Sbjct: 297 KGNEIKVGKQRFQG-----CNNLIKNISNRVGLTLDNI---DDINKAKAVWENIIIVGGT 348 Query: 415 SSIPGLSDRLMTELNK 430 +SI G + L+ +L K Sbjct: 349 TSISGFKEALLGQLLK 364 >5LY3-A nrPDB Length = 432 Score = 45.6 bits (106), Expect = 5e-05, Method: Composition-based stats. Identities = 45/318 (14%), Positives = 95/318 (29%), Gaps = 56/318 (17%) Query: 19 IDPGSYTTNIGYSGSDFPQSI---------LPSVYGKYTADEGNKKIFSEQSIGIPRKDY 69 +D G+ G + P+ + LP + + + + Sbjct: 16 VDFGTSYVKYGPITLNEPKMVQTRGLFLRDLPESVKMRIPPDVLARGLVVGDEEVRKYLS 75 Query: 70 E-------LKPIIENGLVID-----WDTAQEQWQWALQNELYLNSN-SGIPALLTEPVWN 116 LK +++G+ W +E ++ L + +G + Sbjct: 76 SVRDVQRNLKYPLKDGVARRDDEEAWRVLKELARYTLAQFPVSDPEFAGWLVAVALSALA 135 Query: 117 STENRKKSLEVLLE-------GMQFEACYLAPTSTCVSFAAGRPNCLVVDIGHDTCSVSP 169 + + + + A + P V+ A NC++V+ GH V+P Sbjct: 136 P----DYMYKAIFDIYDELASEFKIYAVTILPQPLAVAIAENAVNCVIVEGGHGNIQVAP 191 Query: 170 IVDGMTLSKSTRRNFIAGKFINHLIKKALEPKEIIPLFAIKQRKPEFIKKTFDYEVDKSL 229 I + + + G N + ++ L+ A ++ E +K+ Sbjct: 192 ISFAL-IREGLVALNRGGAEANAITREILKDIG-YSDIAREEYAVEVVKRAVGLVP---- 245 Query: 230 YDYANNRGFFQECKETLCHICPTKTLEETKTELSSTAKRSIESPWNEEIVFDNETRYGFA 289 + KE + TK LS + +E P R+ Sbjct: 246 ----------RRLKEAIRAAKSDPDRFVTKVRLSPVVE--VEIPREYAWT-----RFLIG 288 Query: 290 EELFLPKEDDIPANWPRS 307 E +F P ++I + +S Sbjct: 289 EIVFDPNHEEIKSYIEQS 306 Score = 32.9 bits (73), Expect = 0.35, Method: Composition-based stats. Identities = 21/86 (24%), Positives = 39/86 (45%), Gaps = 11/86 (12%) Query: 385 LADLVYSSIMSSDVDLRATLAHNVVLTGGTSSI---PGLSD-------RLMTELNKILPS 434 +A + +S+ + V+++ +A ++L+GG S PG+ D R+ L + P+ Sbjct: 326 VASAIITSLRNVSVEIQERVASQIILSGGAFSWRVPPGMEDVAADSVTRVKIALEEKSPA 385 Query: 435 LKFRILTTGHTIERQYQSWLGGSILT 460 L ++ E QY W G I Sbjct: 386 LASKVEV-RLVSEPQYSVWRGAVIYG 410 >5LJV-A nrPDB Length = 347 Score = 42.9 bits (99), Expect = 3e-04, Method: Composition-based stats. Identities = 31/192 (16%), Positives = 69/192 (35%), Gaps = 13/192 (6%) Query: 19 IDPGSYTTNIGYSGSDFPQSILPSVYGKYTADEG----NKKIFSEQSIGIPRKDYELKPI 74 +D G+ T S + +L SV G G + R +++ Sbjct: 16 VDLGTSHT--AVMSSRGKKFLLKSVVGYPKDVIGLKLLGRPYVVGDEAFEMRSYLDIRYP 73 Query: 75 IENGLVIDWDTAQ-EQWQWALQNELYLN---SNSGIPALLTEPVWNSTENRKKSLEVLLE 130 +++G++ + E + L + + N I A++ P S N+ L++ E Sbjct: 74 LQDGVLSEISDRDIEVARHLLTHVVKSAEPGPNDEICAVIGVPARASAANKALLLKMAQE 133 Query: 131 GMQFEACYLAPTSTCVSFAAGRP-NCLVVDIGHDTCSVSPIVDGMTLSKSTRRNFIAGKF 189 + V + + N ++VDIG T + + + + AG + Sbjct: 134 V--VHTALVVSEPFMVGYGLDKLINTIIVDIGAGTTDICALKGTVPGPEDQVTLTKAGNY 191 Query: 190 INHLIKKALEPK 201 ++ ++ A+ + Sbjct: 192 VDERLQNAILER 203 >3H1Q-A nrPDB Length = 272 Score = 34.8 bits (78), Expect = 0.087, Method: Composition-based stats. Identities = 30/131 (22%), Positives = 47/131 (35%), Gaps = 4/131 (3%) Query: 46 KYTADEGNKKIF--SEQSIGIP-RKDYELKPIIENGLVIDWDTAQEQWQWALQNELYLNS 102 K D G I GIP + ++++GLV+D+ A + + L Sbjct: 30 KVGVDLGTADIVLVVTDQEGIPVAGALKWASVVKDGLVVDYIGAIQIVRELKAKVERLLG 89 Query: 103 NSGIPALLTEPVWNSTENRKKSLEVLLEGMQFEACYLAPTSTCVSFAAGRPNCLVVDIGH 162 + A P N + V+ G E L + A G + +VVDIG Sbjct: 90 SELFQAATAIPPGTVGRNAEACGHVV-AGAGLELVTLVDEPVAAARALGINDGIVVDIGG 148 Query: 163 DTCSVSPIVDG 173 T ++ I G Sbjct: 149 GTTGIAVIEKG 159 >1JCE-A nrPDB Length = 344 Score = 32.5 bits (72), Expect = 0.39, Method: Composition-based stats. Identities = 38/186 (20%), Positives = 70/186 (37%), Gaps = 15/186 (8%) Query: 41 PSVYGKYTADEGNKKIFSEQSIGIPRKDYELKP--IIENGLVIDWDTAQEQWQWALQNEL 98 PSV + K+ E I + +K + +G++ D+ A ++ N+ Sbjct: 29 PSVIAIDSTTGEILKVGLEAKNMIGKTPATIKAIRPMRDGVIADYTVALVMLRY-FINKA 87 Query: 99 YLNSNSGIPALLTEPVWNSTE-NRKKSLEVLLEGMQFEACYLAPTSTCVSFAAGRPN--- 154 N P ++ T+ R+ L+ LE +L + + Sbjct: 88 KGGMNLFKPRVVIGVPIGITDVERRAILDAGLEA-GASKVFLIEEPMAAAIGSNLNVEEP 146 Query: 155 --CLVVDIGHDTCSVSPIVDGMTLSKSTRRNFIAGKFINHLIKKALEPKEIIPLFAIKQR 212 +VVDIG T V+ I G ++ + R IAG ++ I + + + AI +R Sbjct: 147 SGNMVVDIGGGTTEVAVISLGSIVTWESIR--IAGDEMDEAIVQYVRETYRV---AIGER 201 Query: 213 KPEFIK 218 E +K Sbjct: 202 TAERVK 207 Score = 29.8 bits (65), Expect = 2.8, Method: Composition-based stats. Identities = 11/46 (23%), Positives = 23/46 (50%), Gaps = 1/46 (2%) Query: 383 IGLADLVYSSIMSSDVDLRATLAHN-VVLTGGTSSIPGLSDRLMTE 427 + + + V +++ + +L + + + LTGG S + GL L E Sbjct: 255 VAIVESVRTTLEKTPPELVSDIIERGIFLTGGGSLLRGLDTLLQKE 300 >5WLC-LS nrPDB Length = 594 Score = 31.4 bits (69), Expect = 1.0, Method: Composition-based stats. Identities = 13/72 (18%), Positives = 25/72 (34%), Gaps = 1/72 (1%) Query: 261 ELSSTAKRSIESPWNEEIVFDNETRYGFAEELFLPKEDDIPANWPRSNSGVVKTWRNDYV 320 +L++T SP + + + A L + +NWP S + + K + Sbjct: 513 QLTTTISNLQFSPDGQILCMASRA-VKDALRLVHLPSCSVFSNWPTSGTPLGKVTSVAFS 571 Query: 321 PLKRTKPSGVNK 332 P G + Sbjct: 572 PSGGLLAVGNEQ 583 >6FKM-A nrPDB Length = 715 Score = 31.0 bits (68), Expect = 1.1, Method: Composition-based stats. Identities = 13/85 (15%), Positives = 24/85 (28%), Gaps = 1/85 (1%) Query: 312 VKTWRNDYVPLKRTKPSGVNKSDKKVT-PTEEKEQEAVSKSTSPAANSADTPNETGKRPL 370 ++T D+ L P G V + +V+ +++ G Sbjct: 388 LQTIGEDFCGLDVNSPLGGETPITSVPVAMFNTKLTSVAATSTSGYTVVFVGTSDGFLKK 447 Query: 371 EEEKPPKENNELIGLADLVYSSIMS 395 + NE A + S I Sbjct: 448 VVIESSSIANEYASFAVDLGSEINR 472 >5LNF-A nrPDB Length = 139 Score = 31.0 bits (68), Expect = 1.3, Method: Composition-based stats. Identities = 28/175 (16%), Positives = 54/175 (30%), Gaps = 45/175 (25%) Query: 158 VDIGHDTCSVSPIVDGMTLSKSTRRNFIAGKFINHLIKKALEPKEIIP-LFAIKQRKPEF 216 +D G ++ PI+ + ++ L + P L I ++ PE+ Sbjct: 2 MDEGDGEGNILPIMQSI-------------------MQNLLSKDVLYPSLKEITEKYPEW 42 Query: 217 IKKTFDYEVDKSLYDYANNRGFFQECKETLCHICPTKTLEETKTELSSTAKRSIESPWNE 276 ++ + + +QE +C IC E ++ R Sbjct: 43 LQSHRESLPPEQF-------EKYQEQHSVMCKICEQFEAETPTDSETTQKARF------- 88 Query: 277 EIVFDNETRYGFAEELFLPKEDDIPANWPRSNSGVVKTWRNDYVPLKRTKPSGVN 331 E+V D + +L P ++ P N D L + P G + Sbjct: 89 EMVLDLMQQLQ---DLGHPPKELAGEMPPGLNF--------DLDALNLSGPPGAS 132 >3WQT-A nrPDB Length = 484 Score = 31.0 bits (68), Expect = 1.3, Method: Composition-based stats. Identities = 15/76 (19%), Positives = 23/76 (30%), Gaps = 2/76 (2%) Query: 149 AAGRPNCLVVDIGHDTCSVSPIVDGMTLSKSTRRNFIAGKFINHLIKKALEPKEIIPLFA 208 V+DIG D V+ + L + +AG+ I I + L Sbjct: 212 TEKELGACVIDIGEDVTQVA-FYERGELVDA-DSIEMAGRDITDDIAQGLNTSYETAEKV 269 Query: 209 IKQRKPEFIKKTFDYE 224 Q F D + Sbjct: 270 KHQYGHAFYDSASDQD 285 >3Q5R-A nrPDB Length = 284 Score = 29.8 bits (65), Expect = 2.9, Method: Composition-based stats. Identities = 33/189 (17%), Positives = 58/189 (30%), Gaps = 11/189 (5%) Query: 192 HLIKKALEPKEIIPLFAIKQRKPEFIKKTFDYEVDKSLYDYANNRGFFQECKETLCHICP 251 + L ++I E +KK D E++ L+ + + ++ +E L + Sbjct: 44 YYTDSQLIHLDLIKSLKYIGTPLEEMKKAQDLEME-ELFAFYTEQE--RQIREKLDFLS- 99 Query: 252 TKTLEETKTELSSTAKRSIESP-WNEEIVFDNET-RYGFAEELFLPKEDDIPANWPRSNS 309 LE+T + + KR +E P E V D E R E L E+ + A++ + Sbjct: 100 --ALEQTISLVKKRMKRQMEYPALGEVFVLDEEEIRIIQTEAEGLGPENVLNASYSKLKK 157 Query: 310 GVVK---TWRNDYVPLKRTKPSGVNKSDKKVTPTEEKEQEAVSKSTSPAANSADTPNETG 366 + N Y +P S +P P Sbjct: 158 FIESADGFTNNSYGATFSFQPYTSIDEMTYRHIFTPVLTNKQISSITPDMEITTIPKGRY 217 Query: 367 KRPLEEEKP 375 P Sbjct: 218 ACIAYNFSP 226 >6NU3-AV nrPDB Length = 414 Score = 29.1 bits (63), Expect = 4.8, Method: Composition-based stats. Identities = 13/66 (19%), Positives = 21/66 (31%) Query: 83 WDTAQEQWQWALQNELYLNSNSGIPALLTEPVWNSTENRKKSLEVLLEGMQFEACYLAPT 142 +D + + Y L + EN K +L V+ E M EA + T Sbjct: 119 YDAQDKALYTLVNKVQYGIFPDNFTFNLLMDSFIKKENYKDALSVVFEVMMQEAFEVPST 178 Query: 143 STCVSF 148 + Sbjct: 179 QLLSLY 184 >2DU7-A nrPDB Length = 549 Score = 28.7 bits (62), Expect = 5.4, Method: Composition-based stats. Identities = 22/150 (14%), Positives = 42/150 (28%), Gaps = 16/150 (10%) Query: 178 KSTRRNFIAGKFINHLIKKALEPKEIIPLFAIKQRKPEFI-----KKTFDYEVDKSLYDY 232 ++ I G + I KAL + L ++ PEF T + + Sbjct: 145 HLYKKGAIDGDDLVFEIAKALNVSNEMGLKVLETAFPEFKDLKPESTTLTLRSHMTSGWF 204 Query: 233 ANNRGFFQECKETLCHICPTKTLEETKTELSSTAKRSIESP-----------WNEEIVFD 281 ++ K L + + E S + + + Sbjct: 205 ITLSSLIKKRKLPLKLFSIDRCFRREQREDRSHLMSYHSASCVVVGEDVSVDDGKVVAEG 264 Query: 282 NETRYGFAEELFLPKEDDIPANWPRSNSGV 311 ++GF + F P E P + + V Sbjct: 265 LLAQFGFTKFKFKPDEKKSKYYTPETQTEV 294 >2WL8-A nrPDB Length = 126 Score = 28.3 bits (61), Expect = 7.2, Method: Composition-based stats. Identities = 24/155 (15%), Positives = 49/155 (31%), Gaps = 37/155 (23%) Query: 155 CLVVDIGHDTCSVSPIVDGMTLSKSTRRNFIAGKFINHLIKKALEPKEIIP-LFAIKQRK 213 + +D G ++ PI+ + ++ L + P L I ++ Sbjct: 2 AMGMDEGDGEGNILPIMQSI-------------------MQNLLSKDVLYPSLKEITEKY 42 Query: 214 PEFIKKTFDYEVDKSLYDYANNRGFFQECKETLCHICPTKTLEETKTELSSTAKRSIESP 273 PE+++ + + +QE +C IC E ++ R Sbjct: 43 PEWLQSHRESLPPEQF-------EKYQEQHSVMCKICEQFEAETPTDSETTQKARF---- 91 Query: 274 WNEEIVFDNETRYGFAEELFLPKEDDIPANWPRSN 308 E+V D + +L P ++ P N Sbjct: 92 ---EMVLDLMQQLQ---DLGHPPKELAGEMPPGLN 120 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.307 0.118 0.296 Lambda K H 0.267 0.0362 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 16,501,354 Number of Sequences: 36641 Number of extensions: 637580 Number of successful extensions: 1610 Number of sequences better than 10.0: 33 Number of HSP's better than 10.0 without gapping: 48 Number of HSP's successfully gapped in prelim test: 25 Number of HSP's that attempted gapping in prelim test: 1390 Number of HSP's gapped (non-prelim): 133 length of query: 489 length of database: 10,336,785 effective HSP length: 101 effective length of query: 388 effective length of database: 6,636,044 effective search space: 2574785072 effective search space used: 2574785072 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (21.7 bits) S2: 61 (28.3 bits)