BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P80147 (500 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 1OHW-A nrPDB 986 0.0 2JJG-A nrPDB 164 7e-41 2EO5-A nrPDB 132 4e-31 3OKS-A nrPDB 120 2e-27 3R4T-A nrPDB 118 6e-27 1SFF-A nrPDB 117 8e-27 1Z7D-A nrPDB 116 2e-26 3Q8N-A nrPDB 115 3e-26 2EH6-A nrPDB 112 3e-25 4FFC-A nrPDB 110 2e-24 5LL2-A nrPDB 109 2e-24 1ZOD-A nrPDB 106 2e-23 6FYQ-A nrPDB 106 3e-23 5X3F-A nrPDB 105 4e-23 5LH9-A nrPDB 104 7e-23 5M46-A nrPDB 100 1e-21 6IO1-A nrPDB 100 1e-21 5GHG-A nrPDB 100 2e-21 3NTJ-A nrPDB 100 2e-21 4ATP-A nrPDB 99 5e-21 2E54-A nrPDB 98 9e-21 1WKH-A nrPDB 97 1e-20 3NX3-A nrPDB 97 2e-20 6GIO-D nrPDB 95 6e-20 2ZUK-A nrPDB 95 9e-20 3N5M-A nrPDB 94 1e-19 5VIU-A nrPDB 93 3e-19 4ADC-A nrPDB 91 2e-18 4JF0-A nrPDB 88 7e-18 6G4F-A nrPDB 88 1e-17 3FCR-A nrPDB 87 2e-17 4PPM-A nrPDB 83 2e-16 5TI8-A nrPDB 83 3e-16 3RUY-A nrPDB 79 3e-15 5KR3-A nrPDB 77 2e-14 1OAT-A nrPDB 75 7e-14 5G4J-A nrPDB 74 1e-13 3I4J-A nrPDB 74 1e-13 5KR6-A nrPDB 74 2e-13 5EAV-A nrPDB 73 3e-13 4E3Q-A nrPDB 72 4e-13 5KR5-A nrPDB 72 6e-13 6GWI-A nrPDB 72 6e-13 4GRX-A nrPDB 72 7e-13 5KQW-A nrPDB 68 8e-12 3GJU-A nrPDB 68 1e-11 6ERK-A nrPDB 67 1e-11 1S09-A nrPDB 67 2e-11 3HMU-A nrPDB 66 4e-11 4BA4-A nrPDB 62 6e-10 5UC7-A nrPDB 61 1e-09 5DDW-A nrPDB 60 2e-09 3DOD-A nrPDB 57 2e-08 4WYG-A nrPDB 55 5e-08 4UHN-A nrPDB 55 5e-08 5KQU-A nrPDB 55 7e-08 5G0A-A nrPDB 55 8e-08 3A8U-X nrPDB 54 2e-07 2CFB-A nrPDB 52 5e-07 2EPJ-A nrPDB 51 1e-06 5I92-A nrPDB 50 2e-06 3I5T-A nrPDB 50 2e-06 4BQ0-A nrPDB 50 2e-06 3L44-A nrPDB 49 3e-06 5KQT-A nrPDB 49 5e-06 2E7U-A nrPDB 49 7e-06 3BS8-A nrPDB 48 9e-06 5HDM-A nrPDB 43 3e-04 4GSA-A nrPDB 42 9e-04 2CY8-A nrPDB 41 0.001 4E77-A nrPDB 40 0.002 3K28-A nrPDB 40 0.002 4ZM4-A nrPDB 40 0.003 4AOA-A nrPDB 37 0.026 5YKR-A nrPDB 35 0.100 2YKV-A nrPDB 33 0.33 3WY7-A nrPDB 32 0.65 4BMK-A nrPDB 32 0.80 6ED3-A nrPDB 31 1.2 6CBN-A nrPDB 30 2.0 2B0C-A nrPDB 30 2.4 3RJP-A nrPDB 30 3.0 2X8U-A nrPDB 30 3.5 5XXB-B nrPDB 30 3.6 >1OHW-A nrPDB Length = 472 Score = 986 bits (2549), Expect = 0.0, Method: Compositional matrix adjust. Identities = 472/472 (100%), Positives = 472/472 (100%) Query: 29 SQAAAKVDVEFDYDGPLMKTEVPGPRSRELMKQLNIIQNAEAVHFFCNYEESRGNYLVDV 88 SQAAAKVDVEFDYDGPLMKTEVPGPRSRELMKQLNIIQNAEAVHFFCNYEESRGNYLVDV Sbjct: 1 SQAAAKVDVEFDYDGPLMKTEVPGPRSRELMKQLNIIQNAEAVHFFCNYEESRGNYLVDV 60 Query: 89 DGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGILPPENFVEKLRESLL 148 DGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGILPPENFVEKLRESLL Sbjct: 61 DGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGILPPENFVEKLRESLL 120 Query: 149 SVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELETCMINQAPGCPDY 208 SVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELETCMINQAPGCPDY Sbjct: 121 SVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELETCMINQAPGCPDY 180 Query: 209 SILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFVKENQQEEAR 268 SILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFVKENQQEEAR Sbjct: 181 SILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFVKENQQEEAR 240 Query: 269 CLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDISRKHGCAFLVDEV 328 CLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDISRKHGCAFLVDEV Sbjct: 241 CLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDISRKHGCAFLVDEV 300 Query: 329 QTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGFFHKEEFRPNAPYRIFNTWLGDPSK 388 QTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGFFHKEEFRPNAPYRIFNTWLGDPSK Sbjct: 301 QTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGFFHKEEFRPNAPYRIFNTWLGDPSK 360 Query: 389 NLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDLQARYPQFISRVRGRGTFCSFDTPDES 448 NLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDLQARYPQFISRVRGRGTFCSFDTPDES Sbjct: 361 NLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDLQARYPQFISRVRGRGTFCSFDTPDES 420 Query: 449 IRNKLISIARNKGVMLGGCGDKSIRFRPTLVFRDHHAHLFLNIFSDILADFK 500 IRNKLISIARNKGVMLGGCGDKSIRFRPTLVFRDHHAHLFLNIFSDILADFK Sbjct: 421 IRNKLISIARNKGVMLGGCGDKSIRFRPTLVFRDHHAHLFLNIFSDILADFK 472 >2JJG-A nrPDB Length = 449 Score = 164 bits (416), Expect = 7e-41, Method: Compositional matrix adjust. Identities = 125/425 (29%), Positives = 195/425 (45%), Gaps = 43/425 (10%) Query: 69 EAVHFFCNYEESRGNYLVD-VDGNRMLDLYSQISSIPIGYSHPALVKLVQ-QPQNVSTFI 126 + + + S G+YLVD + G R LD+++ ++S +G + PALV + + + + Sbjct: 31 DGLDIVLDLTRSGGSYLVDAITGRRYLDMFTFVASSALGMNPPALVDDREFHAELMQAAL 90 Query: 127 NRPA---LGILPPENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKE 183 N+P+ + + FVE L A + L + G+ + ENA K F W K Sbjct: 91 NKPSNSDVYSVAMARFVETFARVLGDPA---LPHLFFVEGGALAVENALKAAFDW---KS 144 Query: 184 RGQSAFSKEELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDW 243 R A I+ A G +L GAFHGR+ L+ T++K P FDW Sbjct: 145 RHNQAHG--------IDPALGT---QVLHLRGAFHGRSGYTLSLTNTKPTITARFPKFDW 193 Query: 244 P--IAPF--PRLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEG 299 P AP+ P L P ++ +AR + + +A + EPIQ EG Sbjct: 194 PRIDAPYMRPGLDEPAMAALEAEALRQARA---------AFETRPHDIACFVAEPIQGEG 244 Query: 300 GDNHASDDFFRKLRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKM 359 GD H +FF +R++ + + DEVQTG G TG WA++ LD D++ F KK Sbjct: 245 GDRHFRPEFFAAMRELCDEFDALLIFDEVQTGCGLTGTAWAYQQ--LDVAPDIVAFGKKT 302 Query: 360 MTGGFF---HKEEFRPNA---PYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGK 413 G +E N P R+ +TW G+ + + ++ +I+ E L A GK Sbjct: 303 QVCGVMAGRRVDEVADNVFAVPSRLNSTWGGNLTDMVRARRILEVIEAEGLFERAVQHGK 362 Query: 414 VLLTGLLDLQARYPQFISRVRGRGTFCSFDTPDESIRNKLISIARNKGVMLGGCGDKSIR 473 L L +L A +P + RGRG C+F P + R++LI + V++ G ++R Sbjct: 363 YLRARLDELAADFPAVVLDPRGRGLMCAFSLPTTADRDELIRQLWQRAVIVLPAGADTVR 422 Query: 474 FRPTL 478 FRP L Sbjct: 423 FRPPL 427 >2EO5-A nrPDB Length = 419 Score = 132 bits (331), Expect = 4e-31, Method: Compositional matrix adjust. Identities = 124/445 (27%), Positives = 207/445 (46%), Gaps = 76/445 (17%) Query: 78 EESRGNYLVDVDGNRMLDLYSQISSIPIGY-SHPALVKL-VQQPQNVS-----TFINRPA 130 + G ++ DVDGN+ LD S I +G+ SHP ++K+ ++Q Q ++ F N P Sbjct: 29 DHGEGVWIYDVDGNKYLDFTSGIGVNNLGWPSHPEVIKIGIEQMQKLAHAAANDFYNIPQ 88 Query: 131 LGILPPENFVEKLRESLLSVAPKGMSQLITMA-CGSCSNENAFKTIFMWYRSKERGQSAF 189 L +L + L++ +P + + + G+ + E + K + K G+ Sbjct: 89 L----------ELAKKLVTYSPGNFQKKVFFSNSGTEAIEASIKVV------KNTGRK-- 130 Query: 190 SKEELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPI--AP 247 I++F+G FHGRT G ++ T SKA+ + + F + P Sbjct: 131 -------------------YIIAFLGGFHGRTFGSISLTASKAVQRSIVGPFMPGVIHVP 171 Query: 248 FPR-LKYPLEEFVKENQQEEA-RCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHAS 305 +P + P EN E R +E +ED I + VAGI EPIQ EGG Sbjct: 172 YPNPYRNPWHINGYENPSELVNRVIEFIEDYIFVNLVPPEEVAGIFFEPIQGEGGYVIPP 231 Query: 306 DDFFRKLRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTG--- 362 +FF +L+ +++K+G + DEVQ G G TGK +A E++ + DV+T +K + G Sbjct: 232 KNFFAELQKLAKKYGILLVDDEVQMGLGRTGKLFAIENF--NTVPDVITLAKALGGGIMP 289 Query: 363 ---GFFHKE-EFRPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVL--- 415 F K+ +F+P NT+ G+ + ++VI+I+K DLL + GK+ Sbjct: 290 IGATIFRKDLDFKPGMHS---NTFGGNALACAIGSKVIDIVK--DLLPHVNEIGKIFAEE 344 Query: 416 LTGLLDLQARYPQFISRVRGRGTFCSFDTPDESIRNKLISIARNKGVMLGGCGDKSIRFR 475 L GL D VRG G + ++ +R+++I + +G++L G +IR Sbjct: 345 LQGLAD----------DVRGIGLAWGLEYNEKKVRDRIIGESFKRGLLLLPAGRSAIRVI 394 Query: 476 PTLVFRDHHAHLFLNIFSDILADFK 500 P LV + A L+I ++ K Sbjct: 395 PPLVISEEEAKQGLDILKKVIKVVK 419 >3OKS-A nrPDB Length = 451 Score = 120 bits (300), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 128/469 (27%), Positives = 202/469 (43%), Gaps = 53/469 (11%) Query: 46 MKTEVPGPRSRELM-KQLNIIQNAEAVHFFCNYEESRGNYLVDVDGNRMLDLYSQISSIP 104 + T +PGPRS+ L+ ++ + + G + DVDGNR++DL S I+ Sbjct: 15 LATAIPGPRSQALIDRKGTAVARGVGTTMPVYAVRAGGGIVEDVDGNRLIDLGSGIAVTT 74 Query: 105 IGYSHPALVKLVQQPQNVSTFINRPALGILPPENFVEKLRESLLSVAP-KGMSQLITMAC 163 +G S P +V+ V+ V F + + + P E +V + E L + P +G + Sbjct: 75 VGNSAPKVVEAVRS--QVGDFTHTCFM-VTPYEGYV-AVCEQLNRLTPVRGDKRSALFNS 130 Query: 164 GSCSNENAFKTIFMWYRSKERGQSAFSKEELETCMINQAPGCPDYSILSFMGAFHGRTMG 223 GS + ENA K I + K ++++F A+HGRT Sbjct: 131 GSEAVENAVK-IARSHTHKP-------------------------AVVAFDHAYHGRTNL 164 Query: 224 CLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLE--EFVKENQQEEARCLEEVEDLIVKYR 281 +A T +K F I P L YP EF KE + + +I K + Sbjct: 165 TMALTAKVMPYKDGFGPFAPEIYRAP-LSYPFRDAEFGKELATDGELAAKRAITVIDK-Q 222 Query: 282 KKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDISRKHGCAFLVDEVQTGGGSTGKFWAH 341 +A +++EPIQ EGG +D F L D RK+ F+ DEVQTG TG +A Sbjct: 223 IGADNLAAVVIEPIQGEGGFIVPADGFLPTLLDWCRKNDVVFIADEVQTGFARTGAMFAC 282 Query: 342 EHWGLDDPADVMTFSKKMMTGGFFHKEEFRP---NAPY--RIFNTWLGDPSKNLLLAEVI 396 EH G+D D++ +K + G R ++P+ + T+ G+P I Sbjct: 283 EHEGID--PDLIVTAKGIAGGLPLSAVTGRAEIMDSPHVSGLGGTYGGNPIACAAALATI 340 Query: 397 NIIKREDLLSNAAHAGKVLLTGLLDLQARYPQFISRVRGRGTFCSFD-------TPDESI 449 I+ E L++ A K++ L LQA + I VRGRG + + PD + Sbjct: 341 ETIESEGLVARAQQIEKIMKDRLGRLQAEDDR-IGDVRGRGAMIAMELVKAGTTEPDADL 399 Query: 450 RNKLISIARNKGVMLGGCG--DKSIRFRPTLVFRDHHAHLFLNIFSDIL 496 L + A GV++ CG +RF P L D + L++ ++L Sbjct: 400 TKALCAGAHAAGVIVLSCGTYGNVVRFLPPLSIGDDLLNEGLDVLEEVL 448 >3R4T-A nrPDB Length = 467 Score = 118 bits (296), Expect = 6e-27, Method: Compositional matrix adjust. Identities = 124/471 (26%), Positives = 201/471 (42%), Gaps = 51/471 (10%) Query: 45 LMKTEVPGPRSRELMKQ-LNIIQNAEAVHFFCNYEESRGNYLVDVDGNRMLDLYSQISSI 103 L+ TE+PGP S EL K+ + V + G + D DGNR++DL S I+ Sbjct: 31 LLVTEIPGPASLELNKRRAAAVSGGVGVTLPVFVVRAGGGIVEDADGNRLIDLGSGIAVT 90 Query: 104 PIGYSHPALVKLVQQPQNVSTFINRPALGILPPENFVEKLRESLLSVAP-KGMSQLITMA 162 IG S P +V V+ V F + + + P E +V + E L + P G + + Sbjct: 91 TIGNSAPRVVDAVRD--QVEQFTHTCFM-VTPYEQYV-AVAEQLNRITPGSGEKRTVLFN 146 Query: 163 CGSCSNENAFKTIFMWYRSKERGQSAFSKEELETCMINQAPGCPDYSILSFMGAFHGRTM 222 G+ + EN+ K R+ R Q+ +++F A+HGRT Sbjct: 147 SGAEAVENSIKV----ARAHTRKQA----------------------VVAFDYAYHGRTN 180 Query: 223 GCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPL-EEFVKENQQEEARCLEEVEDLIVKYR 281 +A T +K F I P + YP + + ++ + E ++ + Sbjct: 181 LTMALTAKSMPYKSGFGPFAPEIYRAP-VSYPYRDNLLDKDIATDGELAAERAINLIDKQ 239 Query: 282 KKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDISRKHGCAFLVDEVQTGGGSTGKFWAH 341 +A +I+EPI EGG +D F L+ R + F+ DEVQTG TG +A Sbjct: 240 IGAANLAAVIIEPIAGEGGFIVPADGFLPALQRWCRDNDVVFIADEVQTGFARTGAMFAC 299 Query: 342 EHWGLDDPADVMTFSKKMMTGGFFHKEEFRP---NAPYR--IFNTWLGDPSKNLLLAEVI 396 +H ++ D++ +K + G R +AP+ + T+ G+P I Sbjct: 300 DHENVE--PDLIVTAKGIADGFPLSAVTGRAEIMDAPHTSGLGGTFGGNPVACAAALATI 357 Query: 397 NIIKREDLLSNAAHAGKVLLTGLLDLQARYPQFISRVRGRGTFCSFD-------TPDESI 449 I+R+ ++ A ++++ LL LQA + + VRGRG + + PD ++ Sbjct: 358 ETIERDGMVERARQIERLVMDRLLRLQAADDR-LGDVRGRGAMIAMELVKSGTAEPDAAL 416 Query: 450 RNKLISIARNKGVMLGGCG--DKSIRFRPTLVFRDHHAHLFLNIFSDILAD 498 KL + A GV++ CG IR P L D L+I ILAD Sbjct: 417 TQKLAAAAHAAGVIVLTCGMFGNVIRLLPPLTISDELLSEGLDILCQILAD 467 >1SFF-A nrPDB Length = 426 Score = 117 bits (294), Expect = 8e-27, Method: Compositional matrix adjust. Identities = 119/434 (27%), Positives = 187/434 (43%), Gaps = 65/434 (14%) Query: 87 DVDGNRMLDLYSQISSIPIGYSHPALVKLVQ-QPQNVSTFINRPALGILPPENFVEKLRE 145 DV+G LD I+ + G+ HP +V V+ Q + +S +L E ++E L E Sbjct: 37 DVEGREYLDFAGGIAVLNTGHLHPKVVAAVEAQLKKLS----HTCFQVLAYEPYLE-LCE 91 Query: 146 SLLSVAPKGMSQ-LITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELETCMINQAPG 204 + P ++ + + GS + ENA K +K G AFS Sbjct: 92 IMNQKVPGDFAKKTLLVTTGSEAVENAVK--IARAATKRSGTIAFS-------------- 135 Query: 205 CPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAP--FPRLKYPLEEFVKEN 262 GA+HGRT LA T K++ S + P R YP + Sbjct: 136 ----------GAYHGRTHYTLALTG-----KVNPYSAGMGLMPGHVYRALYP----CPLH 176 Query: 263 QQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDISRKHGCA 322 E + + I K + +A I++EP+Q EGG +S F ++LR + +HG Sbjct: 177 GISEDDAIASIHR-IFKNDAAPEDIAAIVIEPVQGEGGFYASSPAFMQRLRALCDEHGIM 235 Query: 323 FLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGF------FHKEEFRPNAPY 376 + DEVQ+G G TG +A E G+ D+ TF+K + GGF E AP Sbjct: 236 LIADEVQSGAGRTGTLFAMEQMGV--APDLTTFAKS-IAGGFPLAGVTGRAEVMDAVAPG 292 Query: 377 RIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDLQARYPQFISRVRGR 436 + T+ G+P + EV+ + ++E+LL A G+ L GLL + ++P+ I VRG Sbjct: 293 GLGGTYAGNPIACVAALEVLKVFEQENLLQKANDLGQKLKDGLLAIAEKHPE-IGDVRGL 351 Query: 437 GTFCSFD--------TPDESIRNKLISIARNKGVMLGGCGD--KSIRFRPTLVFRDHHAH 486 G + + PD + ++++ AR+KG++L CG +R L D Sbjct: 352 GAMIAIELFEDGDHNKPDAKLTAEIVARARDKGLILLSCGPYYNVLRILVPLTIEDAQIR 411 Query: 487 LFLNIFSDILADFK 500 L I S + K Sbjct: 412 QGLEIISQCFDEAK 425 >1Z7D-A nrPDB Length = 433 Score = 116 bits (291), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 105/411 (25%), Positives = 176/411 (42%), Gaps = 64/411 (15%) Query: 78 EESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVK-LVQQPQNVSTFINRPALGILPP 136 + ++G ++ DV+ R D S SS+ G+ HP ++ ++ Q +N+ T +R + P Sbjct: 52 KRAKGVFVYDVNDKRYYDFLSAYSSVNQGHCHPNILNAMINQAKNL-TICSRAFFSV--P 108 Query: 137 ENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELET 196 E+ +LL G +++ M G+ +NE A+K W ++ +K Sbjct: 109 LGICERYLTNLL-----GYDKVLMMNTGAEANETAYKLCRKWGYEVKKIPENMAK----- 158 Query: 197 CMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAP-FPRLKYPL 255 I+ F GRT+GC++ + +K S P AP F ++ Y Sbjct: 159 -------------IVVCKNNFSGRTLGCISASTTKKC-----TSNFGPFAPQFSKVPY-- 198 Query: 256 EEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDI 315 ++ LEE K V IVEPIQ E G SD++ + + DI Sbjct: 199 ---------DDLEALEE--------ELKDPNVCAFIVEPIQGEAGVIVPSDNYLQGVYDI 241 Query: 316 SRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGFFHKEEFRPN-- 373 +K+ F+ DEVQTG G TGK H+ + DV+ K ++GG + N Sbjct: 242 CKKYNVLFVADEVQTGLGRTGKLLCVHHYNVK--PDVILLG-KALSGGHYPISAVLANDD 298 Query: 374 -----APYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDLQARYPQ 428 P +T+ G+P + E +N++ E L NA G L L + + + Sbjct: 299 IMLVIKPGEHGSTYGGNPLAASICVEALNVLINEKLCENAEKLGGPFLEN-LKRELKDSK 357 Query: 429 FISRVRGRGTFCSFDTPDESIRNKLISIA-RNKGVMLGGCGDKSIRFRPTL 478 + VRG+G C+ + +E + I + + G++ DK+IR P L Sbjct: 358 IVRDVRGKGLLCAIEFKNELVNVLDICLKLKENGLITRDVHDKTIRLTPPL 408 >3Q8N-A nrPDB Length = 453 Score = 115 bits (289), Expect = 3e-26, Method: Compositional matrix adjust. Identities = 122/472 (25%), Positives = 200/472 (42%), Gaps = 57/472 (12%) Query: 46 MKTEVPGPRSRELM-KQLNIIQNAEAVHFFCNYEESRGNYLVDVDGNRMLDLYSQISSIP 104 + T +PGP S+EL ++ + + V + G L D DGN+++D S I+ Sbjct: 22 LVTAIPGPISQELQARKQSAVAAGVGVTLPVYVVAAGGGVLADADGNQLIDFGSGIAVTT 81 Query: 105 IGYSHPALVKLVQQPQNVSTFINRPALGILPPENFVEKLRESLLSVAPKGMSQLITM-AC 163 +G S PA+V V Q V+ F + + + P E +V K+ E L + P + + Sbjct: 82 VGNSAPAVVDAVTQ--QVAAFTHTCFM-VTPYEGYV-KVAEHLNRLTPGDHEKRTALFNS 137 Query: 164 GSCSNENAFKTIFMWYRSKERGQSAFSKEELETCMINQAPGCPDYSILSFMGAFHGRTMG 223 G+ + ENA K + R + +++ F A+HGRT Sbjct: 138 GAEAVENAVKIARAYTRRQ--------------------------AVVVFDHAYHGRTNL 171 Query: 224 CLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKK 283 +A T +K F + P YP + + A L DLI K + Sbjct: 172 TMAMTAKNQPYKHGFGPFANEVYRVPT-SYPFRDGETDGAAAAAHAL----DLINK-QVG 225 Query: 284 KKTVAGIIVEPIQSEGGDNHASDDFFRKLRDISRKHGCAFLVDEVQTGGGSTGKFWAHEH 343 VA +++EP+ EGG + F L+ +G F+ DEVQTG TG +A EH Sbjct: 226 ADNVAAVVIEPVHGEGGFVVPAPGFLGALQKWCTDNGAVFVADEVQTGFARTGALFACEH 285 Query: 344 WGLDDPADVMTFSKKMMTGGF------FHKEEFRPNAPYRIFNTWLGDPSKNLLLAEVIN 397 ++ + + K + GG E + T+ G+P VI+ Sbjct: 286 ---ENVVPDLIVTAKGIAGGLPLSAVTGRAEIMDGPQSGGLGGTYGGNPLACAAALAVID 342 Query: 398 IIKREDLLSNAAHAGKVLLTGLLDLQARYPQFISRVRGRGTFCSFD-------TPDESIR 450 I+RE+L++ A G+ +L+ L L A P+ I VRGRG + + PD + Sbjct: 343 TIERENLVARARAIGETMLSRLGALAAADPR-IGEVRGRGAMIAVELVKPGTTEPDADLT 401 Query: 451 NKLISIARNKGVMLGGCG--DKSIRFRPTLVFRDHHAHLFLNIFSDILADFK 500 ++ + A +G+++ CG +RF P L DH L+I + + A+ K Sbjct: 402 KRVAAAAHAQGLVVLTCGTYGNVLRFLPPLSMPDHLLDEGLDILAAVFAEVK 453 >2EH6-A nrPDB Length = 375 Score = 112 bits (281), Expect = 3e-25, Method: Compositional matrix adjust. Identities = 109/426 (25%), Positives = 178/426 (41%), Gaps = 76/426 (17%) Query: 80 SRGNYLVDVDGNRMLDLYSQISSIPIGYSHP----ALVKLVQQPQNVSTFINRPALGILP 135 +G YL D +G LD S I +G+++P AL + V++ +VS P Sbjct: 17 GKGVYLYDEEGKEYLDFVSGIGVNSLGHAYPKLTEALKEQVEKLLHVSNLYENPW----- 71 Query: 136 PENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELE 195 E KL + + ++ G+ S E A K ++R K + + F Sbjct: 72 QEELAHKLVKHFWT-----EGKVFFANSGTESVEAAIKLARKYWRDKGKNKWKF------ 120 Query: 196 TCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPL 255 +SF +FHGRT G L+ T HK F+ P+ P Sbjct: 121 ---------------ISFENSFHGRTYGSLSATGQPKFHK----GFE-PLVP-------- 152 Query: 256 EEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDI 315 ++ D+ Y+ + AGII+E IQ EGG N AS+DF KL++I Sbjct: 153 -----------GFSYAKLNDIDSVYKLLDEETAGIIIEVIQGEGGVNEASEDFLSKLQEI 201 Query: 316 SRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMM----TGGFFHKEEFR 371 ++ ++DEVQTG G TG+F+A++H+ L DV+ +K + G +EE Sbjct: 202 CKEKDVLLIIDEVQTGIGRTGEFYAYQHFNLK--PDVIALAKGLGGGVPIGAILAREEVA 259 Query: 372 PN-APYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDLQARYPQFI 430 + P +T+ G+P A + + + E LL + G L +L Sbjct: 260 QSFTPGSHGSTFGGNPLA--CRAGTVVVDEVEKLLPHVREVGNYFKEKLKELGK------ 311 Query: 431 SRVRGRGTFCSFDTPDESIRNKLISIARNKGVMLGGCGDKSIRFRPTLVFRDHHAHLFLN 490 +V+GRG + E + A KG+++ K +RF P L+ + H ++ Sbjct: 312 GKVKGRGLMLGLELEREC--KDYVLKALEKGLLINCTAGKVLRFLPPLIIQKEHIDRAIS 369 Query: 491 IFSDIL 496 + +IL Sbjct: 370 VLREIL 375 >4FFC-A nrPDB Length = 453 Score = 110 bits (274), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 122/465 (26%), Positives = 193/465 (41%), Gaps = 54/465 (11%) Query: 48 TEVPGPRSRELMKQLNIIQNAEAVHFFCNYE-ESRGNYLVDVDGNRMLDLYSQISSIPIG 106 T +PGPRS L ++ +A Y ++ G +VD DGN +DL + I+ +G Sbjct: 20 TPLPGPRSGALAERRRAAVSAGVGSTAPVYAVDADGGVIVDADGNSFIDLGAGIAVTTVG 79 Query: 107 YSHPALVKLVQQPQNVSTFINRPALGILPPENFVEKLRESLLSVAPKGMSQLITM-ACGS 165 SHPA+ + +T + P E +V+ + E L ++ P + + G+ Sbjct: 80 ASHPAVAAAIAD---QATHFTHTCFMVTPYEQYVQ-VAELLNALTPGDHDKRTALFNSGA 135 Query: 166 CSNENAFKTIFMWYRSKERGQSAFSKEELETCMINQAPGCPDYSILSFMGAFHGRTMGCL 225 + ENA K + A G P ++++F A+HGRT + Sbjct: 136 EAVENAIKVARL------------------------ATGRP--AVVAFDNAYHGRTNLTM 169 Query: 226 ATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFVKENQQEEAR-CLEEVEDLIVKYRKKK 284 A T +K F + P YPL + +E AR + +E I Sbjct: 170 ALTAKSMPYKSQFGPFAPEVYRMPA-SYPLRDEPGLTGEEAARRAISRIETQI-----GA 223 Query: 285 KTVAGIIVEPIQSEGGDNHASDDFFRKLRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHW 344 +++A II+EPIQ EGG + F L + ++G F+ DEVQTG TG ++A EH Sbjct: 224 QSLAAIIIEPIQGEGGFIVPAPGFLATLTAWASENGVVFIADEVQTGFARTGAWFASEHE 283 Query: 345 GLDDPADVMTFSKKMMTGGFFHKEEFRP---NAPYRIFNTWLGDPSKNLLLAEVINI-IK 400 G+ D++T +K + G R +A Y + A V + + Sbjct: 284 GIVP--DIVTMAKGIAGGMPLSAVTGRAELMDAVYAGGLGGTYGGNPVTCAAAVAALGVM 341 Query: 401 REDLLSNAAHAGKVLLTGLLDLQARYPQFISRVRGRGTFCSFDT-------PDESIRNKL 453 RE L A A + +T L A I VRGRG + + PD ++ + Sbjct: 342 RELDLPARARAIEASVTSRLSALAEEVDIIGEVRGRGAMLAIEIVKPGTLEPDAALTKSI 401 Query: 454 ISIARNKGVMLGGCGD--KSIRFRPTLVFRDHHAHLFLNIFSDIL 496 + A ++GV++ CG IR P LV D + SDI+ Sbjct: 402 AAEALSQGVLILTCGTFGNVIRLLPPLVIGDDLLDEGITALSDII 446 >5LL2-A nrPDB Length = 480 Score = 109 bits (273), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 108/441 (24%), Positives = 181/441 (41%), Gaps = 67/441 (15%) Query: 78 EESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVK-LVQQPQNV-----STFINRPAL 131 + + G LVDVDGN+ +DL + S+I +G++H +VK + Q Q + + F + P + Sbjct: 62 DHAHGATLVDVDGNKYIDLLASASAINVGHTHEKVVKAIADQAQKLIHYTPAYFHHVPGM 121 Query: 132 GILPPENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSK 191 +L E L +AP ++++ +A Y ++ Sbjct: 122 ----------ELSEKLAKIAPGNSPKMVSFGNSGSDANDAIIKFARAYTGRQY------- 164 Query: 192 EELETCMINQAPGCPDYSILSFMGAFHGRTMG--CLATTHSKAIHKID--IPSFDWPIAP 247 I+S+MG++HG T G L+ + KI +PS P Sbjct: 165 ------------------IVSYMGSYHGSTYGSQTLSGSSLNMTRKIGPMLPSVVHVPYP 206 Query: 248 FPRLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDD 307 YP E R E + + +T A +++EPIQ +GG A ++ Sbjct: 207 DSYRTYPGET----EHDVSLRYFNEFKKPFESFLPADET-ACVLIEPIQGDGGIIKAPEE 261 Query: 308 FFRKLRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTG----G 363 + + + +HG F +DEV G G TGK WA + + +P D+M+ K + +G Sbjct: 262 YMQLVYKFCHEHGILFAIDEVNQGLGRTGKMWAIQQFKDIEP-DLMSVGKSLASGMPLSA 320 Query: 364 FFHKEEFRP--NAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLD 421 K+E +AP +F T G+P + +++I+ E L+ +A G L+ Sbjct: 321 VIGKKEVMQSLDAPAHLFTT-AGNPVCSAASLATLDVIEYEGLVEKSATDGAYAKQRFLE 379 Query: 422 LQARYPQFISRVRGRGTFCSFD--------TPDESIRNKLISIARNKGVMLGGCGDKSIR 473 +Q R+P I VR G + PD K+I A GV++ +R Sbjct: 380 MQQRHP-MIGDVRMWGLNGGIELVKDPKTKEPDSDAATKVIYYAFAHGVVIITLAGNILR 438 Query: 474 FRPTLVFRDHHAHLFLNIFSD 494 F+P LV L + D Sbjct: 439 FQPPLVIPREQLDQALQVLDD 459 >1ZOD-A nrPDB Length = 433 Score = 106 bits (265), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 114/447 (25%), Positives = 178/447 (39%), Gaps = 81/447 (18%) Query: 78 EESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQN-----VSTFINRPALG 132 E ++G+++ D DG +LD S S +G+ HP +V ++ + S ++RP Sbjct: 30 ERAKGSFVYDADGRAILDFTSGQMSAVLGHCHPEIVSVIGEYAGKLDHLFSEMLSRP--- 86 Query: 133 ILPPENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKE 192 V L L ++ P G+ + + ++ G+ SNE A + Sbjct: 87 -------VVDLATRLANITPPGLDRALLLSTGAESNEAAIR------------------- 120 Query: 193 ELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHS---KAIHKIDIPSFDWPIAPF- 248 M G Y I+ F ++HG T + T+S K + + SF P APF Sbjct: 121 -----MAKLVTG--KYEIVGFAQSWHGMTGAAASATYSAGRKGVGPAAVGSFAIP-APFT 172 Query: 249 --PRLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASD 306 PR F + + L+ DLI R+ +A I EPI S GG D Sbjct: 173 YRPR-------FERNGAYDYLAELDYAFDLI--DRQSSGNLAAFIAEPILSSGGIIELPD 223 Query: 307 DFFRKLRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGFFH 366 + L+ G ++DE QTG G TG +A + G+ D++T SK + G Sbjct: 224 GYMAALKRKCEARGMLLILDEAQTGVGRTGTMFACQRDGV--TPDILTLSKTLGAGLPLA 281 Query: 367 K-------EEFRPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGL 419 EE Y + T + DP + V+++++R+ L++ A G L GL Sbjct: 282 AIVTSAAIEERAHELGYLFYTTHVSDPLPAAVGLRVLDVVQRDGLVARANVMGDRLRRGL 341 Query: 420 LDLQARYPQFISRVRGRGTFCSFDT--------PDESIRNKLISIARNKG-----VMLGG 466 LDL R+ I VRGRG + P + + K+ N G V L G Sbjct: 342 LDLMERF-DCIGDVRGRGLLLGVEIVKDRRTKEPADGLGAKITRECMNLGLSMNIVQLPG 400 Query: 467 CGDKSIRFRPTLVFRDHHAHLFLNIFS 493 G R P L + L L++ Sbjct: 401 MG-GVFRIAPPLTVSEDEIDLGLSLLG 426 >6FYQ-A nrPDB Length = 484 Score = 106 bits (264), Expect = 3e-23, Method: Compositional matrix adjust. Identities = 99/396 (25%), Positives = 170/396 (42%), Gaps = 70/396 (17%) Query: 78 EESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQN-------VSTFINRPA 130 +E G YL DV G +D S + ++ +G+ L + Q STF + PA Sbjct: 68 KEGDGIYLTDVTGKTYIDGVSSLWNVNVGHGRVELAEAAAQQMKKMAFSSAFSTFSHEPA 127 Query: 131 LGILPPENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFS 190 + +L E + S+ P+G++ + + GS SN++A K + +++ + Sbjct: 128 I----------RLAEKIASITPEGLNAVFFTSGGSESNDSAVKLVRHYWKIQ-------- 169 Query: 191 KEELETCMINQAPGCPDY-SILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFP 249 G P+ I+S ++HG + T IP F W +A Sbjct: 170 -------------GKPNKRKIISLKRSYHGVAAASTSVT--------GIPEF-WGMA--- 204 Query: 250 RLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKK-KTVAGIIVEPIQSEGGDNHASDDF 308 + + +F+ + + V+ L + +T+A EP+Q GG +D+ Sbjct: 205 --GHMMTDFLHVDTHYNNTTEQAVQSLCQAIEEAGPETIAAFFAEPVQGAGGVIIPPEDY 262 Query: 309 FRKLRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGF---- 364 F ++R++ +G F+ DEV TG G TGK + E+W D DVMTF+K + +G F Sbjct: 263 FLRIREVCNAYGILFVADEVITGFGRTGKMFGIENW--DVIPDVMTFAKGVTSGYFPLGG 320 Query: 365 ------FHKEEFRPNAPYRIFN--TWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLL 416 H E + + +F+ T+ G P+ + + I IIK E L+ N+ G LL Sbjct: 321 VVVSDPIH-EVLKEKSVGTLFHGFTYSGHPTAAAVALKNIAIIKEERLVENSKRMGDALL 379 Query: 417 TGLLDLQARYPQFISRVRGRGTFCSFDTPDESIRNK 452 GL ++ R + + VR G + + NK Sbjct: 380 HGLKKVKNRL-EIVGDVRFVGLLGAVELMQNPATNK 414 >5X3F-A nrPDB Length = 501 Score = 105 bits (262), Expect = 4e-23, Method: Compositional matrix adjust. Identities = 103/433 (23%), Positives = 169/433 (39%), Gaps = 68/433 (15%) Query: 83 NYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGILPPENFVEK 142 N LVD G +D +G+ +P +V VQ N+ A L + ++ Sbjct: 72 NTLVDTQGQEFIDCLGGFGIFNVGHRNPVVVSAVQ---------NQLAKQPLHSQELLDP 122 Query: 143 LR----ESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELETCM 198 LR ++L ++ P + G+ S E A K + Y+S RG+ Sbjct: 123 LRAMLAKTLAALTPGKLKYSFFCNSGTESVEAALK-LAKAYQSP-RGK------------ 168 Query: 199 INQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSF-DWPIAPFPRLKYPLEE 257 ++ ++ GAFHG+++G L+ T K +P + PF + Sbjct: 169 ---------FTFIATSGAFHGKSLGALSATAKSTFRKPFMPLLPGFRHVPFGNI------ 213 Query: 258 FVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDISR 317 E + + + +K VA +I+EPIQ EGG + +R + Sbjct: 214 -------------EAMRTALNECKKTGDDVAAVILEPIQGEGGVILPPPGYLTAVRKLCD 260 Query: 318 KHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKK-----MMTGGFFHKEEFRP 372 + G ++DEVQTG G TGK +A EH + D++ +K M G EE Sbjct: 261 EFGALMILDEVQTGMGRTGKMFACEHENVQP--DILCLAKALGGGVMPIGATIATEEVFS 318 Query: 373 ---NAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDLQARYPQF 429 + P+ T+ G+P IN++ ++L + A G +LL G L YP Sbjct: 319 VLFDNPFLHTTTFGGNPLACAAALATINVLLEQNLPAQAEQKGDMLLDGFRQLAREYPDL 378 Query: 430 ISRVRGRGTFCSFDTPDESIRNKLISIARNKGVMLGGC--GDKSIRFRPTLVFRDHHAHL 487 + RG+G + + D I S + V++ G K+IR P L L Sbjct: 379 VQEARGKGMLMAIEFVDNEIGYNFASEMFRQRVLVAGTLNNAKTIRIEPPLTLTIEQCEL 438 Query: 488 FLNIFSDILADFK 500 + LA + Sbjct: 439 VIKAARKALAAMR 451 >5LH9-A nrPDB Length = 458 Score = 104 bits (260), Expect = 7e-23, Method: Compositional matrix adjust. Identities = 114/438 (26%), Positives = 183/438 (41%), Gaps = 77/438 (17%) Query: 82 GNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGILPPENFVE 141 GNY+ D+DG RMLD + ++ IG++ A VK Q + GI P F Sbjct: 44 GNYITDIDGQRMLDGVGGLWNVNIGHNR-ASVKAAIAAQLDELAYYQTFDGIAHPRVF-- 100 Query: 142 KLRESLLSV-APKGMSQLITMACGSCSNENAFKTIFM-WYRSKERGQSAFSKEELETCMI 199 L E L + A + M++++ + GS + E A K W S E G++ F Sbjct: 101 DLAERLTGMFAQERMARVLFSSGGSDAVETALKMARQYWIASGEPGRTRF---------- 150 Query: 200 NQAPGCPDYSILSFMGAFHGRTMGCLAT--------THSKAI---HKIDIPSFDWPIAPF 248 LS +HG MG + H + + H +D P Sbjct: 151 -----------LSLRNGYHGVHMGGTSVGGNGVYHYNHGQLLAGCHLLDTPWL------- 192 Query: 249 PRLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDF 308 + P + ++ Q A C+ ++E+ I +T+A +I EP+Q GG D+ Sbjct: 193 --YRNPWD--CRDPQALTAHCIRQLEEQIALL--GAQTIAALIAEPVQGAGGVIVPPADY 246 Query: 309 FRKLRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTG------ 362 + +LR++ +HG + DEV TG G +G WG+ D++ +K + G Sbjct: 247 WPRLREVCDRHGILLIADEVVTGFGRSGCMLGSRGWGV--APDILCLAKGITAGYIPLGA 304 Query: 363 GFFHKE-----EFRPNAPYRIFN--TWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVL 415 F++ E + I + T+ G P+ V++I++ EDL NAA G L Sbjct: 305 TLFNQRIADAIENGQGFSHMIMHGYTYSGHPTACAAALAVLDIVEAEDLPGNAAKVGAQL 364 Query: 416 LTGLLDLQARYPQFISRVRGRGTFCSFD-TPDESIR----------NKLISIARNKGVML 464 L L L RY + VRG+G + D D+ R +++ AR GV++ Sbjct: 365 LEQLQPLVERY-AVVGEVRGKGLMIALDLVSDKRTRQPLDPAAGQPSRIADEARRAGVLV 423 Query: 465 GGCGDKSIRFRPTLVFRD 482 G+K I P + RD Sbjct: 424 RPIGNKIILSPPLTLTRD 441 >5M46-A nrPDB Length = 440 Score = 100 bits (250), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 99/385 (25%), Positives = 158/385 (41%), Gaps = 64/385 (16%) Query: 80 SRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGILPPENF 139 +G LV+ DG ++DL + +GY HPA+++ V + N IL N Sbjct: 33 GQGARLVEEDGRELIDLSGAWGAASLGYGHPAIIEAVSRAAA-----NPAGASILSASNA 87 Query: 140 -VEKLRESLLSVAP-KGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELETC 197 L E L + P +G ++ GS +NE A++ I ++ G++ Sbjct: 88 PAVALAERLTASFPGRGTHKVWFGHSGSDANEAAYRAI-----TRATGRT---------- 132 Query: 198 MINQAPGCPDYSILSFMGAFHGRTMGCLA-TTHSKAIHKIDIPSFDWPIA-PFPRLKYPL 255 +++F+GA+HG T+G +A + HS + D D I P+P P Sbjct: 133 -----------GVIAFIGAYHGCTVGSMAFSGHSV---QADAAKADGLILLPYPDPYRPY 178 Query: 256 EEFVKENQQEEARCLEEVEDLIVKYRKKK------KTVAGIIVEPIQSEGGDNHASDDFF 309 ++ + D ++ K++ ++A +EPIQS+GG D F Sbjct: 179 QD-------------DPTGDAVLALLKERLAAVPAGSIAAAFIEPIQSDGGLIVPPDGFL 225 Query: 310 RKLRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGL--DDPADVMTFSKKMMTGGFFHK 367 RK DI R HG + + DEV+ G +G+ EH G D + Sbjct: 226 RKFADICRAHGISVVCDEVKVGLARSGRLHCFEHEGFVPDILVLGKGLGGGLPLSAVIAP 285 Query: 368 EEFRPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDLQARYP 427 E A T G+P V+ I+ E+L + A GK+L GL L R+ Sbjct: 286 AEILDCASAFAMQTLHGNPVCAAAGLAVLETIEAENLTTAAERKGKLLREGLARLAERH- 344 Query: 428 QFISRVRGRGTFCSFDTPDESIRNK 452 + I +RGRG C E +RN+ Sbjct: 345 ELIGDIRGRGLACGV----ELVRNR 365 >6IO1-A nrPDB Length = 451 Score = 100 bits (249), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 109/444 (24%), Positives = 188/444 (42%), Gaps = 60/444 (13%) Query: 80 SRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGILPPENF 139 G ++ D +G R LD ++ + ++ IG+ L + ++ F+ G+ P Sbjct: 40 GEGVWVWDAEGKRYLDGFAGLWNVNIGHGRRELAEAAREQMERVAFVPT-FFGLASPPTI 98 Query: 140 VEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTI-FMWYRSKERGQSAFSKEELETCM 198 +L L + P + + G+ SNE A K + W+ +GQ K Sbjct: 99 --ELAARLAELFPGPLDHFQFTSGGAESNETAIKIARYYWWL---KGQPERVK------- 146 Query: 199 INQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHK---IDIPSFDWPIAPFPRLKYPL 255 ILS A+HG MG L+ T A + P F AP+ KY Sbjct: 147 -----------ILSRRMAYHGIAMGALSATGVPAYWEGFGPRPPGFIHLTAPY---KYRF 192 Query: 256 EEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDI 315 E + +++ AR ++E+E+ I R+ +T+A I EP+Q GG D ++ + + Sbjct: 193 GEGLT-DEEFVARLVQELEETI--EREGSETIAAFIGEPVQGAGGVVVPPDGYWPAIAAV 249 Query: 316 SRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMT-----GGFFHKEEF 370 RK+G ++DEV TG G TG + + +G+ D++TF+K + + GG +E Sbjct: 250 LRKYGILLILDEVITGFGRTGTLFGMQQYGVQP--DIVTFAKGITSGYVPLGGVGVSDEI 307 Query: 371 RPN--APYRIFN---TWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDLQAR 425 + R+F T+ G P + ++I+ E L NAA +G LL L L+ R Sbjct: 308 AETLASADRVFMHGFTYSGHPVACAVALRNLDILLAERLWENAAASGAYLLQELKRLEER 367 Query: 426 YPQFISRVRGRGTFCSFDT-----------PDESIRNKLISIARNKGVMLGGCGDKSIRF 474 ++ VRG+G + P+ + KL + R +G+++ C I Sbjct: 368 --PYVGEVRGKGLMLLVEVVRDKASKEKFPPEFKLGPKLEAATRRRGIIV-RCTPDGIVM 424 Query: 475 RPTLVFRDHHAHLFLNIFSDILAD 498 P L + + + L+D Sbjct: 425 APPLTISRAECDVLIEGVAAALSD 448 >5GHG-A nrPDB Length = 456 Score = 100 bits (248), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 110/453 (24%), Positives = 186/453 (41%), Gaps = 66/453 (14%) Query: 78 EESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGILPPE 137 E G Y+ DV G R ++ S + S+ +G+S P L + + F + + P Sbjct: 35 ERGDGIYVEDVSGKRYIEAMSGLLSVGVGFSEPRLAEAAARQMKKLPFYHTFSYRSHGP- 93 Query: 138 NFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELETC 197 V L E L+S+AP MS+ GS +N+ K I WYRS G+ K Sbjct: 94 --VIDLAEKLVSMAPVPMSKAYFTNSGSEANDTVVKLI--WYRSNALGEPERKK------ 143 Query: 198 MINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEE 257 I+S +HG T+ + T H+ SFD PI P Sbjct: 144 ------------IISRKRGYHGVTIASASLTGLPNNHR----SFDLPIDRILHTGCP--H 185 Query: 258 FVKENQQEEA------RCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRK 311 F +E Q E+ R +E+E LI+ + T+A I EP+ GG ++ K Sbjct: 186 FYREGQAGESEEQFATRLADELEQLIIA--EGPHTIAAFIGEPVMGAGGVVVPPKTYWEK 243 Query: 312 LRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKM------MTGGFF 365 ++ + +++ + DEV G G TG + + + D D++ SK++ ++ Sbjct: 244 VQAVLKRYDILLIADEVICGFGRTGNLFGSQTF--DMKPDILVMSKQLSSSYLPISAFLI 301 Query: 366 HKEEFRPNA--PYRIFN-----TWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTG 418 ++ + P A ++I T G P + E + II+ DL++NA G + Sbjct: 302 NERVYAPIAEESHKIGTLGTGFTASGHPVAAAVALENLAIIEERDLVANARDRGTYMQKR 361 Query: 419 LLDLQARYPQFISRVRGRGTFCSFD-----------TPDESIRNKLISIARNKGVMLGGC 467 L +LQ +P + VRG G + P ++ K ++ + +GV+ Sbjct: 362 LRELQ-DHP-LVGEVRGVGLIAGVELVTDKQAKTGLEPTGALGAKANAVLQERGVISRAM 419 Query: 468 GDKSIRFRPTLVFRDHHAHLFLNIFSDILADFK 500 GD ++ F P L+ D ++ L D + Sbjct: 420 GD-TLAFCPPLIINDQQVDTMVSALEATLNDVQ 451 >3NTJ-A nrPDB Length = 422 Score = 100 bits (248), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 99/417 (23%), Positives = 174/417 (41%), Gaps = 76/417 (18%) Query: 78 EESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRP----ALGI 133 + +G ++ D++ R D S SS+ G+ HP ++ + T +R +LG+ Sbjct: 33 KRGKGVFVYDIEDRRYYDFLSAYSSVNQGHCHPDILNAMINQAKKLTICSRAFFSDSLGV 92 Query: 134 LPPENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMW-YRSKERGQSAFSKE 192 E+ +L G +++ M G+ ++E A+K W Y K+ +++ Sbjct: 93 ------CERYLTNLF-----GYDKVLMMNTGAEASETAYKLCRKWGYEVKKIPENS---- 137 Query: 193 ELETCMINQAPGCPDYSILSFMGAFHGRTMGCL-ATTHSKAIHKID--IPSFDWPIAPFP 249 I+ F GRT+GC+ A+T K + +P+F Sbjct: 138 ---------------AKIIVCNNNFSGRTLGCVSASTDKKCKNNFGPFVPNF-------- 174 Query: 250 RLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFF 309 LK P ++ LE +E + + V IVEP+Q E G SD +F Sbjct: 175 -LKVPYDD------------LEALEKEL-----QDPNVCAFIVEPVQGEAGVIVPSDSYF 216 Query: 310 RKLRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGFFHKEE 369 + + +K+ F+ DEVQTG G TGK H+G+ DV+ K ++GG + Sbjct: 217 PGVASLCKKYNVLFVADEVQTGLGRTGKLLCTHHYGVK--PDVILLG-KALSGGHYPISA 273 Query: 370 FRPN-------APYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDL 422 N P +T+ G+P + E + ++ E L NA G L L + Sbjct: 274 ILANDDVMLVLKPGEHGSTYGGNPLAAAICVEALKVLINEKLCENADKLGAPFLQNLKE- 332 Query: 423 QARYPQFISRVRGRGTFCSFDTPDESIRNKLISIA-RNKGVMLGGCGDKSIRFRPTL 478 Q + + + VRG+G C+ + ++ + I + + G++ DK++R P L Sbjct: 333 QLKDSKVVREVRGKGLLCAIEFKNDLVNVWDICLKFKENGLITRSVHDKTVRLTPPL 389 >4ATP-A nrPDB Length = 456 Score = 98.6 bits (244), Expect = 5e-21, Method: Compositional matrix adjust. Identities = 116/455 (25%), Positives = 193/455 (42%), Gaps = 60/455 (13%) Query: 51 PGPRSRELMKQLNIIQNAEAVHFFCNY-EESRGNYLVDVDGNRMLDLYSQISSIPIGYSH 109 PGP+S+ L ++ + + A Y E++ G + DVDGN +DL S I+ +G S Sbjct: 23 PGPKSQALAERRSAVVAAGVASGVPVYVEDADGGIIRDVDGNSFIDLGSGIAVTSVGASD 82 Query: 110 PALVKLVQQPQNVSTFINRPALGILPPENFVEKLRESLLSVAPKGMSQ-LITMACGSCSN 168 PA+V VQ+ + + P E +V + E L + P ++ + G+ + Sbjct: 83 PAVVAAVQE---AAAHFTHTCFMVTPYEGYV-AVTEQLNRLTPGDHAKRTVLFNSGAEAV 138 Query: 169 ENAFKTIFMWYRSKERGQSAFSKEELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATT 228 ENA K + G+ A +++F A+HGRT +A T Sbjct: 139 ENAVKVARL-----ATGRDA---------------------VVAFDHAYHGRTNLTMALT 172 Query: 229 HSKAIHKIDIPSFDWPIAPFPRLKYPLEEFVKENQQEEA--RCLEEVEDLIVKYRKKKKT 286 +K + F + P + YP E E EA R + +E I Sbjct: 173 AKAMPYKTNFGPFAPEVYRMP-MSYPFREENPEITGAEAAKRAITMIEKQI-----GGDQ 226 Query: 287 VAGIIVEPIQSEGGDNHASDDFFRKLRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGL 346 VA II+EPIQ EGG ++ F L + +++ G F+ DEVQ+G TG+++A +H G+ Sbjct: 227 VAAIIIEPIQGEGGFIVPAEGFLPALSEWAKEKGIVFIADEVQSGFCRTGEWFAVDHEGV 286 Query: 347 DDPADVMTFSKKMMTGGFFHKEEFRPNA-----PYRIFNTWLGDPSKNLLLAEVINIIKR 401 D++T +K + G R + P + T+ G+P I+ +++ Sbjct: 287 --VPDIITMAKGIAGGLPLSAITGRADLLDAVHPGGLGGTYGGNPVACAAALAAIDTMEQ 344 Query: 402 EDLLSNAAHAGKVLLTGLLDLQARYP----QFISRVRGRGTFCSFD-------TPDESIR 450 DL A H ++ L L +L A + +RGRG + + P+ + Sbjct: 345 HDLNGRARHIEELALGKLRELAAELSAGGGSVVGDIRGRGAMLAIELVQPGSKEPNAELT 404 Query: 451 NKLISIARNKGVMLGGCG--DKSIRFRPTLVFRDH 483 + + +GV++ CG IR P LV D Sbjct: 405 KAVAAACLKEGVIILTCGTYGNVIRLLPPLVISDE 439 >2E54-A nrPDB Length = 385 Score = 97.8 bits (242), Expect = 9e-21, Method: Compositional matrix adjust. Identities = 103/426 (24%), Positives = 169/426 (39%), Gaps = 69/426 (16%) Query: 80 SRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQ-QPQNV----STFINRPALGIL 134 +G+++ D GN LD S I+ +G+SHP LV+ ++ Q + + + F NRP + + Sbjct: 17 GKGSWIYDEKGNAYLDFTSGIAVNVLGHSHPRLVEAIKDQAEKLIHCSNLFWNRPQMEL- 75 Query: 135 PPENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEEL 194 LLS G ++ G+ +NE A K + + K Sbjct: 76 ----------AELLSKNTFG-GKVFFANTGTEANEAAIKIARKYGKKKSE---------- 114 Query: 195 ETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYP 254 Y ILS +FHGRT+G L T P + P P P Sbjct: 115 -----------KKYRILSAHNSFHGRTLGSLTATGQ--------PKYQKPFEPL----VP 151 Query: 255 LEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRD 314 E+ + N E+ R RK + V + +EPIQ E G A+ +F + R Sbjct: 152 GFEYFEFNNVEDLR------------RKMSEDVCAVFLEPIQGESGIVPATKEFLEEARK 199 Query: 315 ISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMM----TGGFFHKEEF 370 + ++ + DEVQ G G TGK +A++ +G+ DV+T +K + G E Sbjct: 200 LCDEYDALLVFDEVQCGMGRTGKLFAYQKYGV--VPDVLTTAKGLGGGVPIGAVIVNERA 257 Query: 371 RPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDLQARYPQFI 430 P T+ G+P VI + +E L G L+ L +++ Y + Sbjct: 258 NVLEPGDHGTTFGGNPLACRAGVTVIKELTKEGFLEEVEEKGNYLMKKLQEMKEEY-DVV 316 Query: 431 SRVRGRGTFCSFDTPDESIRNKLISIARNKGVMLGGCGDKSIRFRPTLVFRDHHAHLFLN 490 + VRG G +E ++ + +++ G+ +IRF P L L + Sbjct: 317 ADVRGMGLMIGIQFREEVSNREVATKCFENKLLVVPAGNNTIRFLPPLTVEYGEIDLAVE 376 Query: 491 IFSDIL 496 +L Sbjct: 377 TLKKVL 382 >1WKH-A nrPDB Length = 395 Score = 97.4 bits (241), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 103/423 (24%), Positives = 168/423 (39%), Gaps = 66/423 (15%) Query: 80 SRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGILPPENF 139 +G + D +GN +D +G+ +P +V+ V++ T + P LP Sbjct: 34 GQGARVWDAEGNEYIDCVGGYGVANLGHGNPEVVEAVKR--QAETLMAMPQ--TLPTPMR 89 Query: 140 VEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELETCMI 199 E R +L ++ P ++++ + G+ +NE A K + G+ F Sbjct: 90 GEFYR-TLTAILPPELNRVFPVNSGTEANEAALK-----FARAHTGRKKF---------- 133 Query: 200 NQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFV 259 ++ M F GRTMG L+ T P + P P L P+E F+ Sbjct: 134 -----------VAAMRGFSGRTMGSLSVTWE--------PKYREPFLP---LVEPVE-FI 170 Query: 260 KENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDISRKH 319 N E + R + A +I+EP+Q EGG A+ +F R R+I+++ Sbjct: 171 PYNDVEALK------------RAVDEETAAVILEPVQGEGGVRPATPEFLRAAREITQEK 218 Query: 320 GCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTG-----GFFHKEEFRPNA 374 G ++DE+QTG G TGK +A EH+G+ D++T +K + G +E R Sbjct: 219 GALLILDEIQTGMGRTGKRFAFEHFGIVP--DILTLAKALGGGVPLGVAVMREEVARSMP 276 Query: 375 PYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDLQARYPQFISRVR 434 T+ G+P I ++R L AA G + L+A I VR Sbjct: 277 KGGHGTTFGGNPLAMAAGVAAIRYLERTRLWERAAELGPWFME---KLRAIPSPKIREVR 333 Query: 435 GRGTFCSFDTPDESIRNKLISIARNKGVMLGGCGDKSIRFRPTLVFRDHHAHLFLNIFSD 494 G G + E + + + V+ G IRF P LV + Sbjct: 334 GMGLMVGLEL-KEKAAPYIARLEKEHRVLALQAGPTVIRFLPPLVIEKEDLERVVEAVRA 392 Query: 495 ILA 497 +LA Sbjct: 393 VLA 395 >3NX3-A nrPDB Length = 395 Score = 96.7 bits (239), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 108/414 (26%), Positives = 177/414 (42%), Gaps = 63/414 (15%) Query: 78 EESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGILPPE 137 E+ +G YL D + LD S I +GY+H ++ V ++ L E Sbjct: 23 EKGQGVYLFDDKAKKYLDFSSGIGVCALGYNHAKFNAKIKA--QVDKLLHTSNL--YYNE 78 Query: 138 NFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELETC 197 N + + A + ++ G+ S E A KT + AF+K Sbjct: 79 NIAAAAKNLAKASA---LERVFFTNSGTESIEGAMKTARKY---------AFNK------ 120 Query: 198 MINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEE 257 G ++F +FHGRT+G L+ T ++ K PF L ++ Sbjct: 121 ------GVKGGQFIAFKHSFHGRTLGALSLTANEKYQK-----------PFKPLISGVK- 162 Query: 258 FVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDISR 317 F K N + VE L+ +KT A II+E +Q EGG N A+ DF++ LR + Sbjct: 163 FAKYND------ISSVEKLV-----NEKTCA-IILESVQGEGGINPANKDFYKALRKLCD 210 Query: 318 KHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKK----MMTGGFFHKEEFRPN 373 + + DE+Q G G +GKF+A+EH + D+MT +K + G F ++ N Sbjct: 211 EKDILLIADEIQCGMGRSGKFFAYEHAQI--LPDIMTSAKALGCGLSVGAFVINQKVASN 268 Query: 374 A--PYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDLQARYPQFIS 431 + +T+ G+P + V I K E +L N L L +L + F Sbjct: 269 SLEAGDHGSTYGGNPLVCAGVNAVFEIFKEEKILENVNKLTPYLEQSLDELINEF-DFCK 327 Query: 432 RVRGRGTFCSFDTPDESIR-NKLISIARNKGVMLGGCGDKSIRFRPTLVFRDHH 484 + +G G F + D+S++ K+I + ++L CG+ +RF P L+ + H Sbjct: 328 KRKGLG-FMQGLSLDKSVKVAKVIQKCQENALLLISCGENDLRFLPPLILQKEH 380 >6GIO-D nrPDB Length = 439 Score = 95.1 bits (235), Expect = 6e-20, Method: Compositional matrix adjust. Identities = 94/370 (25%), Positives = 149/370 (40%), Gaps = 50/370 (13%) Query: 80 SRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGILPPENF 139 +GN L++ G +LDL +GY HPA+V+ V++ +V L L P Sbjct: 31 GKGNRLIEEGGRSILDLSGSAGPAALGYGHPAIVEAVEK--SVRDMAGASLL--LYPNEA 86 Query: 140 VEKLRESLLSVAP-KGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELETCM 198 L E LL + P G ++ GS +N+ A + + +A +K Sbjct: 87 AVSLAEDLLRITPGNGERRVWFGHSGSDANDCAVRVL-----------TAATKRS----- 130 Query: 199 INQAPGCPDYSILSFMGAFHGRTMGCLATT-HSKAIHKIDIPSFDWPIAPFPRLKYPLEE 257 I+SF+G++HG G + + H+ H + P + P+P P Sbjct: 131 ----------RIISFIGSYHGNLTGSMGISGHTAMTHTLPRPGV--LLLPYPDPFRP--- 175 Query: 258 FVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDISR 317 + A + E+ D + VA + +EPI S+GG F L+D R Sbjct: 176 ------RFSAEAVLELLDYHFATSCPPEQVAAVFIEPILSDGGLVVPPPAFLEALQDRCR 229 Query: 318 KHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTF----SKKMMTGGFFHKEEFRPN 373 KHG +VDEV+ G G TG +H GL+ D++ F + + + Sbjct: 230 KHGILVVVDEVKVGLGRTGLMHCFQHEGLE--PDMVVFGKGLGGGLPLSAVVGPQWVMDH 287 Query: 374 APYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDLQARYPQFISRV 433 AP + T G+P V+N I+R+ L + G + L L ++ I V Sbjct: 288 APAFVLQTTAGNPVATAAGRAVLNTIERQGLAQRSERVGGIFADRLRRLSDKH-SIIGDV 346 Query: 434 RGRGTFCSFD 443 RGRG D Sbjct: 347 RGRGLAIGVD 356 >2ZUK-A nrPDB Length = 439 Score = 94.7 bits (234), Expect = 9e-20, Method: Compositional matrix adjust. Identities = 112/443 (25%), Positives = 170/443 (38%), Gaps = 55/443 (12%) Query: 65 IQNAEAVHFF-CNYEESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVS 123 I N + + FF RG L++ +G ++DL + +GY HPA+V V Sbjct: 16 IGNLQKLRFFPLAISGGRGARLIEENGRELIDLSGAWGAASLGYGHPAIVAAVSAAAANP 75 Query: 124 TFINRPALGILPPENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKE 183 + P E+L L S +G ++ GS +NE A++ I K Sbjct: 76 AGATILSASNAPAVTLAERL---LASFPGEGTHKIWFGHSGSDANEAAYRAIV-----KA 127 Query: 184 RGQSAFSKEELETCMINQAPGCPDYSILSFMGAFHGRTMGCLA-TTHSKAIHKIDIPSFD 242 G+S +++F GA+HG T+G +A + HS + D D Sbjct: 128 TGRS---------------------GVIAFAGAYHGCTVGSMAFSGHSV---QADAAKAD 163 Query: 243 WPIA-PFPRLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGD 301 I P+P P + + +A E L ++ +EPIQS+GG Sbjct: 164 GLILLPYPDPYRPY----RNDPTGDAILTLLTEKLAAV---PAGSIGAAFIEPIQSDGGL 216 Query: 302 NHASDDFFRKLRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGL--DDPADVMTFSKKM 359 D F RK DI R HG + DEV+ G +G+ EH G D + Sbjct: 217 IVPPDGFLRKFADICRAHGILVVCDEVKVGLARSGRLHCFEHEGFVPDILVLGKGLGGGL 276 Query: 360 MTGGFFHKEEFRPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGL 419 E A T G+P V+ I R+DL + A G++L GL Sbjct: 277 PLSAVIAPAEILDCASAFAMQTLHGNPISAAAGLAVLETIDRDDLPAMAERKGRLLRDGL 336 Query: 420 LDLQARYPQFISRVRGRGTFCSFD--------TPDESIRNKLISIARNKGVML--GGCGD 469 +L R+P I +RGRG C + P + KLI A G+++ G Sbjct: 337 SELAKRHP-LIGDIRGRGLACGMELVCDRQSREPARAETAKLIYRAYQLGLVVYYVGMNG 395 Query: 470 KSIRFRPTLVFRDHHAHLFLNIF 492 + F P L + H L++ Sbjct: 396 NVLEFTPPLTITETDIHKALDLL 418 >3N5M-A nrPDB Length = 452 Score = 94.4 bits (233), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 105/430 (24%), Positives = 178/430 (41%), Gaps = 67/430 (15%) Query: 79 ESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLV-QQPQNVSTF----INRPALGI 133 ++ G ++ D+ G R LD S + + GY L + +Q Q +S F + PA+ Sbjct: 37 KAEGCWVEDIQGKRYLDGMSGLWCVNSGYGRKELAEAAYKQLQTLSYFPMSQSHEPAI-- 94 Query: 134 LPPENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEE 193 EKL E L G + GS +NE AFK +Y K Sbjct: 95 ----KLAEKLNEWL-----GGEYVIFFSNSGSEANETAFKIARQYYAQK----------- 134 Query: 194 LETCMINQAPGCPD-YSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLK 252 G P Y +S +HG TM +A T P + P Sbjct: 135 ----------GEPHRYKFMSRYRGYHGNTMATMAATGQAQRRYQYEPFASGFLHVTPPDC 184 Query: 253 YPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKL 312 Y + +EN + C++EV+ ++ + +T+A I+EPI + GG A D+ + + Sbjct: 185 YRMPGIERENIYD-VECVKEVDRVMT--WELSETIAAFIMEPIITGGGILMAPQDYMKAV 241 Query: 313 RDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGFFH------ 366 + +KHG + DEV G G TGK + ++ D D++T +K +T + Sbjct: 242 HETCQKHGALLISDEVICGFGRTGKAFGFMNY--DVKPDIITMAKG-ITSAYLPLSATAV 298 Query: 367 ----KEEFRPNAPYRIF---NTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGL 419 E F+ Y F NT+ G+P+ L + + II+ E+L+ +A G +LL L Sbjct: 299 KREIYEAFKGKGEYEFFRHINTFGGNPAACALALKNLEIIENENLIERSAQMGSLLLEQL 358 Query: 420 LDLQARYPQFISRVRGRGTFCSFDTPD-----ESIRN----KLISIARNKGVMLGGCGDK 470 + +P + +RG+G + + E I N +++ + KG+++G G Sbjct: 359 KEEIGEHP-LVGDIRGKGLLVGIELVNDKETKEPIDNDKIASVVNACKEKGLIIGRNGMT 417 Query: 471 SIRFRPTLVF 480 + + L Sbjct: 418 TAGYNNILTL 427 >5VIU-A nrPDB Length = 419 Score = 92.8 bits (229), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 108/438 (24%), Positives = 179/438 (40%), Gaps = 72/438 (16%) Query: 78 EESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVK-LVQQPQNVS----TFINRPALG 132 + G ++ DV+G + D S S++ G+SHP +V+ LV+Q ++ F N LG Sbjct: 38 DRGEGVFVWDVEGKKYYDFLSAYSAVNQGHSHPKIVEALVEQASKLALTSRAFYNS-KLG 96 Query: 133 ILPPENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKE 192 + +K+ SLL G +++ M G+ + E A K W S E A + Sbjct: 97 -----EYEQKIT-SLL-----GFDKVLPMNSGAEAVETAVKLARKW--SYEVKGIAENAA 143 Query: 193 ELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAP-FPRL 251 ++ C N FHGRT ++ ++ D P P F R+ Sbjct: 144 KIIVCENN----------------FHGRTTTIVSFSNDP-----DANQNYGPFTPGFIRI 182 Query: 252 KYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRK 311 Y + LEEV K+ +A +VEPIQ E G ++ F ++ Sbjct: 183 PY-----------NDIAALEEV------LSKEAGNIAAFLVEPIQGEAGVYVPNEGFLKQ 225 Query: 312 LRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGFFHKEEFR 371 ++ +KH F+ DEVQTG TGK A H D D++ K ++GG + Sbjct: 226 SSELCKKHNVLFIADEVQTGIARTGKLIACHHE--DVQPDILILG-KALSGGMYPVSAVL 282 Query: 372 PN-------APYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDLQA 424 N P + +T+ G+P + +++++ E L A G + + + L Sbjct: 283 ANNNIMDVIKPGQHGSTFGGNPLACAVAMAALDVVQDEKLSERAEKLGNLFRSEIEKLIE 342 Query: 425 RYPQFISRVRGRGTFCSF---DTPDESIRNKLISIARNKGVMLGGCGDKSIRFRPTLVFR 481 + I++VRG+G + DTPD S L + G++ IR P LV Sbjct: 343 K-TDLITKVRGKGLLNAILINDTPDSSTAWNLCLALKENGLLAKPTHGNIIRLAPPLVIT 401 Query: 482 DHHAHLFLNIFSDILADF 499 + + I + +F Sbjct: 402 EEQLLDCVKIIEKTILEF 419 >4ADC-A nrPDB Length = 406 Score = 90.5 bits (223), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 98/433 (22%), Positives = 166/433 (38%), Gaps = 73/433 (16%) Query: 80 SRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQP-----QNVSTFINRPALGIL 134 G+ L D G +D I+ +G++HP L + + + + + N P L Sbjct: 28 GEGSRLWDQQGKEYIDFAGGIAVNALGHAHPELREALNEQASKFWHTGNGYTNEPVL--- 84 Query: 135 PPENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEEL 194 +KL ++ + ++ G+ +NE A K L Sbjct: 85 ---RLAKKLIDATFA------DRVFFCNSGAEANEAALK--------------------L 115 Query: 195 ETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYP 254 + G I++F AFHGRT+ ++ P++ AP P Sbjct: 116 ARKFAHDRYGSHKSGIVAFKNAFHGRTLFTVSAGGQ--------PAYSQDFAPLP----- 162 Query: 255 LEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRD 314 + + + LI + +IVEPIQ EGG AS+ F + LR+ Sbjct: 163 -----ADIRHAAYNDINSASALI------DDSTCAVIVEPIQGEGGVVPASNAFLQGLRE 211 Query: 315 ISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGFFHKEEFRPNA 374 + +H + DEVQTG G TG+ +A+ H+G+ D++T + K + GGF Sbjct: 212 LCNRHNALLIFDEVQTGVGRTGELYAYMHYGVTP--DLLT-TAKALGGGFPVGALLATEE 268 Query: 375 PYRIF------NTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDLQARYPQ 428 R+ T+ G+P + + +V+ +I ++L+ + L + RY Sbjct: 269 CARVMTVGTHGTTYGGNPLASAVAGKVLELINTPEMLNGVKQRHDWFVERLNTINHRYGL 328 Query: 429 FISRVRGRGTF--CSFDTPDESIRNKLISIARNKGVMLGGCGDKSIRFRPTLVFRDHHAH 486 F S VRG G C + ++ A GVM+ G +RF P L + Sbjct: 329 F-SEVRGLGLLIGCVLNADYAGQAKQISQEAAKAGVMVLIAGGNVVRFAPALNVSEEEVT 387 Query: 487 LFLNIFSDILADF 499 L+ F+ F Sbjct: 388 TGLDRFAAACEHF 400 >4JF0-A nrPDB Length = 422 Score = 88.2 bits (217), Expect = 7e-18, Method: Compositional matrix adjust. Identities = 100/434 (23%), Positives = 168/434 (38%), Gaps = 77/434 (17%) Query: 79 ESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQP-----QNVSTFINRPALGI 133 + +G+ + D G +D I+ +G+ HPALV+ ++ F N PAL Sbjct: 45 KGKGSRVWDQQGKEYIDFAGGIAVTALGHCHPALVEALKSQGETLWHTSRVFTNEPAL-- 102 Query: 134 LPPENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEE 193 KL ++ + +++ M G+ +NE AFK R + Sbjct: 103 ----RLGRKLIDATFA------ERVLFMNSGTEANETAFKL--------ARHYACVRHSP 144 Query: 194 LETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPR--L 251 +T I++F AFHGR++ ++ P + P P + Sbjct: 145 FKT------------KIIAFHNAFHGRSLFTVSVGGQ--------PKYSDGFGPKPADII 184 Query: 252 KYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRK 311 P + VK T A ++VEPIQ EGG A+ +F + Sbjct: 185 HVPFNDLHA-----------------VKAVMDDHTCA-VVVEPIQGEGGVQAATPEFLKG 226 Query: 312 LRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGFFHKEEFR 371 LRD+ +H + DEVQ G G TG +A+ H+G+ D++T S K + GGF Sbjct: 227 LRDLCDEHQALLVFDEVQCGMGRTGDLFAYMHYGVT--PDILT-SAKALGGGFPVSAMLT 283 Query: 372 PNAPYRIF------NTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDLQAR 425 F +T+ G+P + +II ++L + + L + + Sbjct: 284 TQEIASAFHVGSHGSTYGGNPLACAVAGATFDIINTPEVLQGIHTKRQQFVQHLQAIDEQ 343 Query: 426 YPQFISRVRGRGTFCSFD-TPDESIRNK-LISIARNKGVMLGGCGDKSIRFRPTLVFRDH 483 + F S +RG G + P R + + GVM+ G +RF P+LV + Sbjct: 344 FDIF-SDIRGMGLLIGAELKPKYKGRARDFLYAGAEAGVMVLNAGADVMRFAPSLVVEEA 402 Query: 484 HAHLFLNIFSDILA 497 H + F+ + Sbjct: 403 DIHEGMQRFAQAVG 416 >6G4F-A nrPDB Length = 464 Score = 87.8 bits (216), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 103/465 (22%), Positives = 186/465 (40%), Gaps = 94/465 (20%) Query: 78 EESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFIN-------RPA 130 E G Y+ D G ++ + + S +G+S+ L+K +Q N F + RP+ Sbjct: 35 ERGEGIYVYDDQGKGYIEAMAGLWSAALGFSNQRLIKAAEQQFNTLPFYHLFSHKSHRPS 94 Query: 131 LGILPPENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFS 190 + +L E L+ +AP MS++ GS +N+ K + WY + G+ A Sbjct: 95 I----------ELAEKLIEMAPVPMSKVFFTNSGSEANDTVVKMV--WYLNNALGKPAKK 142 Query: 191 KEELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPR 250 K +S + +HG T+ + T + FD P+ F Sbjct: 143 K------------------FISRVNGYHGITVASASLTGLPGNQR----GFDLPLPGFLH 180 Query: 251 LKYPLE-EFVKENQQEEA---RCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASD 306 + P F + EE R E+E I+ + +T+A I EP+ GG Sbjct: 181 VGCPHHYRFALAGESEEHFADRLAVELEQKILA--EGPETIAAFIGEPLMGAGGVIVPPR 238 Query: 307 DFFRKLRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGFFH 366 ++ K++ + RK+ + DEV G G TG+ + + +G+ D+M SK++ + Sbjct: 239 TYWEKIQKVCRKYDILVIADEVICGFGRTGQMFGSQTFGIQP--DIMVLSKQLSS----- 291 Query: 367 KEEFRP------NAPYRIFN----------------TWLGDPSKNLLLAEVINIIKREDL 404 ++P NAP +F T G P + E + II+ E L Sbjct: 292 --SYQPIAAILINAP--VFEGIADQSQALGALGHGFTGSGHPVATAVALENLKIIEEESL 347 Query: 405 LSNAAHAGKVLLTGLLDLQARYPQFISRVRGRGTFCSFDTPDESIRNK-----------L 453 + +AA G++L +GL +P + +RG G + + + + + Sbjct: 348 VEHAAQMGQLLRSGLQHF-IDHP-LVGEIRGCGLIAAVELVGDRVSKAPYQALGTLGRYM 405 Query: 454 ISIARNKGVMLGGCGDKSIRFRPTLVFRDHHAHLFLNIFSDILAD 498 A+ G++ GD ++ F P L+ + + + F+ L D Sbjct: 406 AGRAQEHGMITRAMGD-AVAFCPPLIVNEQEVGMIVERFARALDD 449 >3FCR-A nrPDB Length = 458 Score = 86.7 bits (213), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 87/382 (22%), Positives = 160/382 (41%), Gaps = 51/382 (13%) Query: 80 SRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVK-LVQQPQNVSTFINRPALGILPPEN 138 + G ++ D DG ++LD ++ + + +GY + + + Q + ++ + + G E Sbjct: 39 ASGVFIEDRDGTKLLDAFAGLYCVNVGYGRQEIAEAIADQARELAYYHSYVGHGT---EA 95 Query: 139 FVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELETCM 198 + L + +L APK MS++ GS +NE K I WY + G+ K Sbjct: 96 SI-TLAKMILDRAPKNMSKVYFGLGGSDANETNVKLI--WYYNNILGRPEKKK------- 145 Query: 199 INQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPL--- 255 I+S +HG + + T + HK FD P+ + P Sbjct: 146 -----------IISRWRGYHGSGLVTGSLTGLELFHK----KFDLPVEQVIHTEAPYYFR 190 Query: 256 -EEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRD 314 E+ + +Q A C+ E+E LI R+ T+A I EPI GG ++ ++ Sbjct: 191 REDLNQTEEQFVAHCVAELEALI--EREGADTIAAFIGEPILGTGGIVPPPAGYWEAIQT 248 Query: 315 ISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKM------MTGGFFHKE 368 + KH + DEV TG G G + +H+GL+ D++T +K + ++G + Sbjct: 249 VLNKHDILLVADEVVTGFGRLGTMFGSDHYGLE--PDIITIAKGLTSAYAPLSGSIVSDK 306 Query: 369 EFR-------PNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLD 421 ++ N P T+ P + ++ +L+SNA G L + + Sbjct: 307 VWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAE 366 Query: 422 LQARYPQFISRVRGRGTFCSFD 443 +++ + VRG G C+ + Sbjct: 367 ALSQHAN-VGDVRGEGLLCAVE 387 >4PPM-A nrPDB Length = 861 Score = 83.2 bits (204), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 99/428 (23%), Positives = 165/428 (38%), Gaps = 83/428 (19%) Query: 77 YEESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQ-----QPQNVSTFINRPAL 131 + + G L D G LD+ + + +G++ +V ++ Q N +I+ P Sbjct: 419 FRSAAGTQLYDDAGEAFLDMVAGYGCLNLGHNPQPVVNALKNYLDAQGPNFIQYISIP-- 476 Query: 132 GILPPENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSK 191 KL E L +AP M ++ G+ + E A K Sbjct: 477 ------EQTAKLAEVLCRLAPGNMGRVFFSNSGTEAVEAAMK------------------ 512 Query: 192 EELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPI-APFPR 250 + + G P + L ++HG+T+G L+ T + P D + PF Sbjct: 513 ------IAKASTGKPGIAYLR--NSYHGKTLGALSITGRDKHRRYFTPLLDAMVEVPFGD 564 Query: 251 LKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFR 310 L E +E+ V +++EPIQ EGG + + + Sbjct: 565 LAALREALNRED------------------------VGALMIEPIQGEGGVHIPPAGYLQ 600 Query: 311 KLRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTG-------- 362 ++ + R+ G +VDEVQTG G TGK +A E G++ DV+ SK + G Sbjct: 601 AVQQLCRETGVLLMVDEVQTGLGRTGKLFACEWDGIE--PDVLMLSKSLSGGLIPIGATL 658 Query: 363 ---GFFHKEEFRPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGL 419 + K + +T+ G +++ + I +DL+ +A G L Sbjct: 659 CRADLWQKAYGTADRFLVHSSTYGGGNLASVVALSALREILAQDLVGHAERMGAYFKQAL 718 Query: 420 LDLQARYPQFISRVRGRGTFCSFDTPDESIRNKLISIARNKGVMLGGCGDKSIRFRPTLV 479 ++ ARYP F+S VRGRG D++ + + AR L G + +F P V Sbjct: 719 SEIAARYP-FVSEVRGRGLMLGIQF-DQAFTGAVNASAREFATRLPGDWHTTWKFLPDPV 776 Query: 480 FRDHHAHL 487 AHL Sbjct: 777 ----QAHL 780 >5TI8-A nrPDB Length = 474 Score = 82.8 bits (203), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 89/394 (22%), Positives = 158/394 (40%), Gaps = 64/394 (16%) Query: 79 ESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGILPPEN 138 ++ G YL D +GN++LD + + + +GY L ++ + + N PP Sbjct: 60 KAEGVYLWDSEGNKILDGMAGLWCMNVGYGRKELAEVAYKQMLELPYYNLFFQTAHPP-- 117 Query: 139 FVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELETCM 198 +L +++ +AP+GM+ + GS SN+ + + ++ K + Q Sbjct: 118 -ALELAKAIADIAPEGMNHVFFTGSGSESNDTVLRMVRHYWSIKGKPQKKV--------- 167 Query: 199 INQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPL--- 255 ++ +HG T+ ++ KA+H D PI + P Sbjct: 168 -----------VIGRWNGYHGSTVAGVSLGGMKALHS----QGDLPIPGIVHIAQPYWYG 212 Query: 256 -------EEF-VKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDD 307 EEF V +Q E + LE E+ VA I EPIQ GG D Sbjct: 213 EGGDMSAEEFGVWAAEQLEKKILEVGEE----------NVAAFIAEPIQGAGGVIVPPDT 262 Query: 308 FFRKLRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMT-----G 362 ++ K+R+I K+ F+ DEV G G TG+++ +++G + D+M +K + + G Sbjct: 263 YWPKIREILAKYEILFIADEVICGFGRTGEWFGSQYYG--NAPDLMPIAKGLTSGYIPMG 320 Query: 363 GFFHKEE----FRPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTG 418 G ++E + T+ G P + E I I++ E ++ L Sbjct: 321 GVIVRDEIVDTLNEGGEFYHGFTYSGHPVAAAVALENIRILREEKIVETVKAETAPYLQK 380 Query: 419 LLDLQARYPQFISRVRGRGTFCSFDTPDESIRNK 452 A +P + RG G + E ++NK Sbjct: 381 RWQELADHP-LVGEARGVGMVGAL----ELVKNK 409 >3RUY-A nrPDB Length = 392 Score = 79.3 bits (194), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 96/417 (23%), Positives = 168/417 (40%), Gaps = 74/417 (17%) Query: 79 ESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRP----ALGIL 134 ++ G ++ D +GNR +DL S S++ G+ HP ++ + N T +R LG Sbjct: 24 KAEGVWVEDPEGNRYMDLLSAYSAVNQGHRHPKIINALIDQANRVTLTSRAFHSDQLG-- 81 Query: 135 PPENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEEL 194 P V KL ++ M G+ + E A KT W ++ ++ ++ E+ Sbjct: 82 PWYEKVAKLTNK---------EMVLPMNTGAEAVETAIKTARRWAYDVKKVEA--NRAEI 130 Query: 195 ETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIA-PFPRLKY 253 C N FHGRTMG ++ + ++ + P I P+ L+ Sbjct: 131 IVCEDN----------------FHGRTMGAVSMSSNEEYKRGFGPMLPGIIVIPYGDLE- 173 Query: 254 PLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLR 313 L+ + N A I+EPIQ E G N F ++ Sbjct: 174 ALKAAITPN------------------------TAAFILEPIQGEAGINIPPAGFLKEAL 209 Query: 314 DISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGFF-------H 366 ++ +K F+ DE+QTG G TGK +A + W D+ M K + GG F + Sbjct: 210 EVCKKENVLFVADEIQTGLGRTGKVFACD-W--DNVTPDMYILGKALGGGVFPISCAAAN 266 Query: 367 KEEFRPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDLQARY 426 ++ P +T+ G+P + + +++ E L + G+ L+ L ++ Sbjct: 267 RDILGVFEPGSHGSTFGGNPLACAVSIAALEVLEEEKLTERSLQLGEKLVGQLKEIDN-- 324 Query: 427 PQFISRVRGRGTFCSFDTPDESIRNKLISIARNKGVMLGGCGDKSIRFRPTLVFRDH 483 I+ VRG+G F + +E R + + G++ + IR P LV + Sbjct: 325 -PMITEVRGKGLFIGIEL-NEPARPYCEQL-KAAGLLCKETHENVIRIAPPLVISEE 378 >5KR3-A nrPDB Length = 479 Score = 76.6 bits (187), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 86/384 (22%), Positives = 147/384 (38%), Gaps = 55/384 (14%) Query: 80 SRGNYLVDVDGNRMLDLYSQISSIPIGYSHP----ALVKLVQQPQNVSTFINRPALGILP 135 +G + D +G +D ++ + + IGY A+ + +Q T++ Sbjct: 58 GKGIRIEDHEGREYIDAFAGLYCVNIGYGRTEVADAIYEQAKQLAYYHTYVGHST----- 112 Query: 136 PENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELE 195 + +E + AP GM ++ GS +NE K +WY + G+ K Sbjct: 113 -DAIIELSSRIIRDWAPAGMKKVYYGMSGSDANETQIK--LVWYYNNVLGRPNKKK---- 165 Query: 196 TCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPL 255 I+S +HG + + T + H+ FD PI P Sbjct: 166 --------------IISRERGYHGSGIVTGSLTGLPSFHQ----HFDLPIDRVKHTVCPH 207 Query: 256 EEFVKENQQEE---ARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKL 312 E A C+EE+E LI R+ T+A I EP+ GG ++ + Sbjct: 208 WYRAPAGMSEAQFVAYCVEELEKLIA--REGADTIAAFIAEPVMGTGGIIPPPQGYWEAI 265 Query: 313 RDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTG-----GFFHK 367 + + RKH + DEV G G G +H+G+ D++T +K + + G Sbjct: 266 QAVLRKHDILLIADEVVCGFGRLGSKMGSQHYGIK--PDLITVAKGLTSAYAPLSGVIVG 323 Query: 368 EEF--------RPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGL 419 E+ + + P T+ G P ++I++RE+L NAA G L L Sbjct: 324 EKVWDVIEKGSQEHGPMGHGWTYSGHPICAAAALANLDILERENLTGNAADVGAYLQQRL 383 Query: 420 LDLQARYPQFISRVRGRGTFCSFD 443 + +P + VRG G + + Sbjct: 384 HEAFGAHP-LVGEVRGVGMLAALE 406 >1OAT-A nrPDB Length = 439 Score = 75.1 bits (183), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 94/440 (21%), Positives = 171/440 (38%), Gaps = 81/440 (18%) Query: 78 EESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRP----ALGI 133 E +G YL DV+G + D S S++ G+ HP +V ++ + T +R LG Sbjct: 63 ERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYNNVLGE 122 Query: 134 LPPENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEE 193 E ++ KL +++ M G + E A K W + + Q +K Sbjct: 123 Y--EEYITKLFN---------YHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAK-- 169 Query: 194 LETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHK---IDIPSFDW-PIAPFP 249 I+ G F GRT+ ++++ + +P FD P P Sbjct: 170 ----------------IVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPYNDLP 213 Query: 250 RLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFF 309 L+ L++ VA +VEPIQ E G + Sbjct: 214 ALERALQD---------------------------PNVAAFMVEPIQGEAGVVVPDPGYL 246 Query: 310 RKLRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGFF---- 365 +R++ +H F+ DE+QTG TG++ A ++ + D++ K ++GG + Sbjct: 247 MGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVR--PDIVLLGKA-LSGGLYPVSA 303 Query: 366 ---HKEEFRPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDL 422 + P +T+ G+P + + +++ E+L NA G +L L+ L Sbjct: 304 VLCDDDIMLTIKPGEHGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNELMKL 363 Query: 423 QARYPQFISRVRGRGTFCSF---DTPDESIRNKLISIARNKGVMLGGCGDKSIRFRPTLV 479 + ++ VRG+G + +T D + + R+ G++ IRF P LV Sbjct: 364 PS---DVVTAVRGKGLLNAIVIKETKDWDAWKVCLRL-RDNGLLAKPTHGDIIRFAPPLV 419 Query: 480 FRDHHAHLFLNIFSDILADF 499 ++ + I + + F Sbjct: 420 IKEDELRESIEIINKTILSF 439 >5G4J-A nrPDB Length = 446 Score = 74.3 bits (181), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 102/438 (23%), Positives = 170/438 (38%), Gaps = 65/438 (14%) Query: 82 GNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGILPPENFVE 141 G +L D G LD Y+ + + G+++PA+ + Q Q ++ ++ L + V Sbjct: 46 GVWLTDAQGKVYLDGYNNVPHV--GHANPAVADAIYQ-QLLTVNLHTRYL-----NSRVV 97 Query: 142 KLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELETCMINQ 201 + E+LLS + +L GS +NE A + + S FS T + Sbjct: 98 EYAEALLSKFDGALERLFLTNSGSEANELALRIARQHTGNTGVLVSDFSYHGNTTSLAEI 157 Query: 202 APGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFVKE 261 G + L G + L I ++D+P LE+ Sbjct: 158 TTGLTVHEPL-------GAHVRALRIPDVSGIAEVDVPVL-------------LEQ---- 193 Query: 262 NQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDISRKHGC 321 L +V+ I + V+ + +P+ S G + + R G Sbjct: 194 -------SLADVDAAIASLQAAGHGVSVFLFDPLFSTEGLLQLPSGYIEGVATRVRAAGG 246 Query: 322 AFLVDEVQTGGGSTGK-FWAHEHWGLDDPADVMTFSKKMMTGGFFHK--------EEF-R 371 + DEVQ+G G TG W ++ + ++ +++T K M G +EF R Sbjct: 247 LVISDEVQSGFGRTGSGMWGYQMFNVE--PELVTMGKPMGNGHPIGAVVTTAELLDEFGR 304 Query: 372 PNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDLQARYPQFIS 431 N FNT+ G+P + V+ + +EDL++ A GK + L ++ R + Sbjct: 305 HNM---FFNTFAGNPVSSAAGLAVLRYMDQEDLMAKADQLGKYIRKRLENIAQRSGN-VG 360 Query: 432 RVRGRGTFCSFD--------TPDESIRNKLISIARNKGVMLGGCG--DKSIRFRPTLVFR 481 VRGRG F D P ++ LI R +GV++ G D ++ RP LVF Sbjct: 361 SVRGRGLFFGIDIIESDGSRNPAPALTKILIEDMRERGVLISRVGPHDNVLKMRPPLVFG 420 Query: 482 DHHAHLFLNIFSDILADF 499 HA + L LA Sbjct: 421 REHADILLGQLELSLASL 438 >3I4J-A nrPDB Length = 430 Score = 74.3 bits (181), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 72/283 (25%), Positives = 123/283 (43%), Gaps = 46/283 (16%) Query: 208 YSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSF---DWPIAPFPRLKYPLEEFVKENQQ 264 + +++ + ++HG ++G LA + A ++ P WP P P N Sbjct: 122 FKVITRVPSYHGASLGSLAASGMGARRELYTPLMRPEAWPKLPKPD--------PARNGA 173 Query: 265 EEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHA---SDDFFRKLRDISRKHGC 321 E+A L + + R+ +TVA + EP+ G + A + ++ ++RDI + G Sbjct: 174 EDAEGLRALLE-----REGPETVAAFMAEPVV--GASDAALAPAPGYYERVRDICDEAGI 226 Query: 322 AFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTG-----GFF-----HKEEFR 371 F+ DEV +G G G A W P D+ K + G G ++ Sbjct: 227 IFIADEVMSGMGRCGSPLALSRWSGVTP-DIAVLGKGLAAGYAPLAGLLAAPQVYETVMG 285 Query: 372 PNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDLQARYPQFIS 431 + + T+ G P V++I++REDL A G LL GL LQAR+PQ + Sbjct: 286 GSGAFMHGFTYAGHPVSVAAGLSVLDIVEREDLTGAAKERGAQLLAGLQALQARFPQMM- 344 Query: 432 RVRGR-----------GTFCSFDTPDESIRNKLISIARNKGVM 463 +VRG T +F+TP I +++ + A +G++ Sbjct: 345 QVRGTGLLLGVVLGDLATGQAFETP--GIASRIGAAALKRGLI 385 >5KR6-A nrPDB Length = 479 Score = 73.6 bits (179), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 89/419 (21%), Positives = 159/419 (37%), Gaps = 75/419 (17%) Query: 80 SRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLV-QQPQNVS---TFINRPALGILP 135 +G + D +G +D ++ + + +GY + + +Q + ++ T++ Sbjct: 58 GKGIRIQDSEGREYIDAFAGLYCVNVGYGRTEIADAIYEQAKELAYYHTYVGHSN----- 112 Query: 136 PENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELE 195 E +E + AP GMS++ GS +NE K +WY + G+ K Sbjct: 113 -EPIIELSERIIREWAPAGMSKVYYGMSGSDANETQIK--LVWYYNNVLGRPQKKK---- 165 Query: 196 TCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPL 255 I+S +HG + + T A H FD P+ P P Sbjct: 166 --------------IISRQRGYHGSGIMTGSLTGLPAFHN----HFDLPLEPIRHTTCPH 207 Query: 256 EEFVKENQQEEA---RCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKL 312 E C +E+E +I+ + TVA I EP+ GG + ++ + Sbjct: 208 YYRAPAGMSEAEFSRHCADELEKMILA--EGPDTVAAFIGEPVMGTGGIVPPPEGYWEAI 265 Query: 313 RDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKM------MTGGFFH 366 + + K+ + DEV G G TG + H+G+ D++T +K + ++G Sbjct: 266 QAVLNKYDILLIADEVVCGFGRTGSMFGSHHYGMK--PDLITVAKGLTSAYAPLSGVIVG 323 Query: 367 KEEFR-------PNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGL 419 ++ ++ P T+ G P ++II+RE+L NAA G + Sbjct: 324 EKVWKVLEQGSDQYGPIGHGWTYSGHPICAAAALANLDIIERENLTGNAADTGAYFQQRM 383 Query: 420 LDLQARYPQFISRVRGRGTFCSFDTPDESIRNKLISIARNKGVMLGGCGDKSIRFRPTL 478 + +P + VRG G + E + +K DK RF P+L Sbjct: 384 RETFGDHP-LVGEVRGVGLMAAL----EFVADK----------------DKRTRFDPSL 421 >5EAV-A nrPDB Length = 441 Score = 72.8 bits (177), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 93/432 (21%), Positives = 171/432 (39%), Gaps = 68/432 (15%) Query: 79 ESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVK-LVQQPQNVSTFINRPALGILPPE 137 + +G + D++GN D + +SS+ G+ HP ++ L +Q + ++ + + P Sbjct: 58 KGKGARVWDINGNEYYDFLAGVSSLSQGHCHPRVIAALCRQAERLTLTLRAFGNDVTGPA 117 Query: 138 -NFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELET 196 F+ ++ G +++ M G+ + E+A K W A+ +E+ Sbjct: 118 CRFMAEMF---------GYDRVLLMNTGAEAGESALKIARKW---------AYEVKEIP- 158 Query: 197 CMINQAPGCPDYS-ILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAP-FPRLKYP 254 PD + ++ + GRT+ +++ + D + P P F + Y Sbjct: 159 ---------PDSAKVILCNNNYWGRTITACSSSTT-----FDCYNNFGPFTPGFELIDY- 203 Query: 255 LEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRD 314 ++ LEE K VA VEPIQ EGG N + ++ + Sbjct: 204 ----------DDVGALEEA--------LKDPNVAAFFVEPIQGEGGVNVPKPGYLKRAHE 245 Query: 315 ISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTG------GFFHKE 368 + R +VDE+QTG TG+ A +H + D++ K + G + Sbjct: 246 LCRSKNVLLIVDEIQTGLCRTGRLLAADHDEVH--PDILLLGKSLSAGVVPISAVMGRAD 303 Query: 369 EFRPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGL-LDLQARYP 427 P +T+ G+P + E + ++K E L A G L +L + P Sbjct: 304 VMDVLKPGTHGSTFGGNPLACAVAVEALTVLKDEKLADRAERLGAQFRDCLRRELYGKVP 363 Query: 428 QFISRVRGRGTFCSFDTPDESIR-NKLISIARNKGVMLGGCGDKSIRFRPTLVFRD-HHA 485 +I +RGRG + + ++I N ++ + G++ + +RF P LV D H Sbjct: 364 -WIKEIRGRGLLNAVEVDSDAIDPNDVVMKLKENGILSKPTRGRVMRFIPPLVITDEEHR 422 Query: 486 HLFLNIFSDILA 497 I LA Sbjct: 423 DATTRIIKSFLA 434 >4E3Q-A nrPDB Length = 473 Score = 72.4 bits (176), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 76/291 (26%), Positives = 119/291 (40%), Gaps = 39/291 (13%) Query: 80 SRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPAL-GILPPEN 138 G Y+VDV+G R LD S + ++ G+ H L+ + F A G + + Sbjct: 56 GEGPYIVDVNGRRYLDANSGLWNMVAGFDHKGLIDAAKA--QYERFPGYHAFFGRMSDQT 113 Query: 139 FVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELETCM 198 + L E L+ V+P ++ GS +N+ K +W+ G+ K Sbjct: 114 VM--LSEKLVEVSPFDSGRVFYTNSGSEANDTMVK--MLWFLHAAEGKPQKRK------- 162 Query: 199 INQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYP-LEE 257 IL+ A+HG T A+ K + + F P+ F L P Sbjct: 163 -----------ILTRWNAYHGVT-AVSASMTGKPYNSV----FGLPLPGFVHLTCPHYWR 206 Query: 258 FVKENQQEE---ARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRD 314 + +E + EE AR E+E+ I R+ T+AG EP+ GG + +F+ + Sbjct: 207 YGEEGETEEQFVARLARELEETI--QREGADTIAGFFAEPVMGAGGVIPPAKGYFQAILP 264 Query: 315 ISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGFF 365 I RK+ + DEV G G TG W + A + S K +T GFF Sbjct: 265 ILRKYDIPVISDEVICGFGRTGNTWGCVTYDFTPDAII---SSKNLTAGFF 312 >5KR5-A nrPDB Length = 479 Score = 72.0 bits (175), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 82/381 (21%), Positives = 144/381 (37%), Gaps = 49/381 (12%) Query: 80 SRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLV-QQPQNVSTFINRPALGILPPEN 138 +G + D +G +D ++ + + IGY + + +Q + ++ + P Sbjct: 58 GKGIRIEDHEGREYIDAFAGLYCVNIGYGREEVADAIYEQAKQLAYYHTYVGHSNDPVIE 117 Query: 139 FVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELETCM 198 ++ E AP GM ++ GS +NE K +WY + G+ K Sbjct: 118 LSSRIIEDW---APAGMKKVFYGMSGSDANETQIK--LVWYYNNVLGRPNKKK------- 165 Query: 199 INQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEF 258 I++ ++HG + + T + H+ FD PI P Sbjct: 166 -----------IIARERSYHGSGIVTGSLTGLPSFHQ----HFDLPIDRVKHTVCPHWYN 210 Query: 259 VKENQQEE---ARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDI 315 E A C+EE+E LI R+ T+A I EP+ GG ++ ++ + Sbjct: 211 APPGMSEAQFVAYCVEELEKLIA--REGADTIAAFIAEPVMGTGGIVPPPQGYWEAIQAV 268 Query: 316 SRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGFFHKEEFRPNAP 375 RKH + DEV G G G EH+G+ D++T +K + + Sbjct: 269 LRKHDILLIADEVVCGFGRLGSKTGSEHYGIK--PDLITVAKGLTSAYAPLSAVIVSEKV 326 Query: 376 YRIFN-------------TWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDL 422 + + T+ G P ++I++RE+L NAA G L L + Sbjct: 327 WDVIEKGSREHGVMGHGWTYSGHPVCAAAALANLDILERENLTGNAADVGAYLQQRLHEA 386 Query: 423 QARYPQFISRVRGRGTFCSFD 443 +P + VRG G + + Sbjct: 387 FGAHP-LVGEVRGVGMLAALE 406 >6GWI-A nrPDB Length = 462 Score = 71.6 bits (174), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 64/287 (22%), Positives = 121/287 (42%), Gaps = 36/287 (12%) Query: 80 SRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGILPPENF 139 + G Y+ D +GNR+LD + + + +GY LV+ + N PP Sbjct: 36 AEGVYIHDSEGNRILDGMAGLWCVNLGYGRRELVEAATAQLEQLPYYNTFFKTTHPP--- 92 Query: 140 VEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELETCMI 199 +L E L +AP ++++ GS +N+ + + ++ K Sbjct: 93 AVRLAEKLCDLAPAHINRVFFTGSGSEANDTVLRMVRRYWALK----------------- 135 Query: 200 NQAPGCPDYS-ILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEF 258 G PD I+ A+HG T+ ++ +H P + ++ P Sbjct: 136 ----GQPDKQWIIGRENAYHGSTLAGMSLGGMAPMHAQGGPC----VPGIAHIRQPYWFG 187 Query: 259 VKENQQEEA---RCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDI 315 + EA C E +E+ I++ ++K VA I EP+Q GG + ++ ++ + Sbjct: 188 EGRDMSPEAFGQTCAEALEEKILELGEEK--VAAFIAEPVQGAGGAIMPPESYWPAVKKV 245 Query: 316 SRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTG 362 K+ + DEV G G G+++ +H+GL+ D+M +K + +G Sbjct: 246 LAKYDILLVADEVICGFGRLGEWFGSQHYGLE--PDLMPIAKGLSSG 290 >4GRX-A nrPDB Length = 465 Score = 71.6 bits (174), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 75/294 (25%), Positives = 117/294 (39%), Gaps = 45/294 (15%) Query: 80 SRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQN----VSTFINRPALGILP 135 G Y+VDV G R LD S + ++ G+ H L++ + + F R + Sbjct: 48 GEGPYIVDVHGRRYLDANSGLWNMVAGFDHKGLIEAAKAQYDRFPGYHAFFGRMS----- 102 Query: 136 PENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELE 195 + L E L+ V+P ++ GS +N+ K +W+ G+ K Sbjct: 103 --DQTVMLSEKLVEVSPFDNGRVFYTNSGSEANDTMVK--MLWFLHAAEGKPQKRK---- 154 Query: 196 TCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYP- 254 IL+ A+HG T A+ K + + F P+ F L P Sbjct: 155 --------------ILTRWNAYHGVT-AVSASMTGKPYNSV----FGLPLPGFIHLTCPH 195 Query: 255 LEEFVKENQQEE---ARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRK 311 + +E + E AR E+ED I R+ T+AG EP+ GG + +F+ Sbjct: 196 YWRYGEEGETEAQFVARLARELEDTIT--REGADTIAGFFAEPVMGAGGVIPPAKGYFQA 253 Query: 312 LRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGFF 365 + I RK+ + DEV G G TG W + A + S K +T GFF Sbjct: 254 ILPILRKYDIPMISDEVICGFGRTGNTWGCLTYDFMPDAII---SSKNLTAGFF 304 >5KQW-A nrPDB Length = 479 Score = 68.2 bits (165), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 84/387 (21%), Positives = 153/387 (39%), Gaps = 61/387 (15%) Query: 80 SRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLV-QQPQNVS---TFINRPALGILP 135 +G + D +G +D ++ + + IGY + + +Q + ++ T++ Sbjct: 58 GKGIRIQDHEGREYIDAFAGLYCVNIGYGRTEVADAIYEQAKELAYYHTYVGHST----- 112 Query: 136 PENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELE 195 E +E + AP GM ++ GS +NE K +WY + G+ K Sbjct: 113 -EAIIELSSRIIRDWAPAGMKKVYYGMSGSDANETQIK--LVWYYNNVLGRPQKKK---- 165 Query: 196 TCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPL 255 I+S +HG + + T + H+ FD PI R+K+ + Sbjct: 166 --------------IISRQRGYHGSGIMTGSLTGLPSFHQ----HFDLPIE---RIKHTV 204 Query: 256 --EEFVKENQQEEAR----CLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFF 309 + EA+ C +E+E LI+ + TVA I EP+ GG ++ Sbjct: 205 CPHWYKAPAGMSEAQFVRYCADELEKLILA--EGPDTVAAFIGEPVMGTGGIIPPPQGYW 262 Query: 310 RKLRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTG-----GF 364 ++ + K+ + DEV G G G +H+G+ D++T +K + + G Sbjct: 263 EAIQAVLNKYDILLIADEVVCGFGRLGSKMGSQHYGMK--PDLITVAKGLTSAYAPLSGV 320 Query: 365 FHKEEF--------RPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLL 416 E+ + + P T+ G P ++I++RE+L NAA G L Sbjct: 321 IVGEKVWDVIEKGSQEHGPMGHGWTYSGHPICAAAALANLDILERENLTGNAADVGAYLQ 380 Query: 417 TGLLDLQARYPQFISRVRGRGTFCSFD 443 L + +P + VRG G + + Sbjct: 381 QRLRETFGGHP-LVGEVRGVGMLAALE 406 >3GJU-A nrPDB Length = 460 Score = 67.8 bits (164), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 64/280 (22%), Positives = 121/280 (43%), Gaps = 37/280 (13%) Query: 87 DVDGNRMLDLYSQISSIPIGYSHPALV-KLVQQPQNVSTFINRPALGILPPENFVEKLRE 145 D +G + +D ++ + + +GY + + Q +N++ + G E + L + Sbjct: 47 DNNGRKSIDAFAGLYCVNVGYGRQKIADAIATQAKNLAYYHAYVGHGT---EASI-TLAK 102 Query: 146 SLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELETCMINQAPGC 205 ++ APKGMS++ GS +NE K I WY + G+ K Sbjct: 103 MIIDRAPKGMSRVYFGLSGSDANETNIKLI--WYYNNVLGRPEKKK-------------- 146 Query: 206 PDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPL----EEFVKE 261 I+S +HG + + T H +FD P AP + P + Sbjct: 147 ----IISRWRGYHGSGVMTGSLTGLDLFHN----AFDLPRAPVLHTEAPYYFRRTDRSMS 198 Query: 262 NQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDISRKHGC 321 +Q C +++E++I+ + +T+A I EPI GG ++ K++ + +K+ Sbjct: 199 EEQFSQHCADKLEEMILA--EGPETIAAFIGEPILGTGGIVPPPAGYWEKIQAVLKKYDV 256 Query: 322 AFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMT 361 + DEV TG G G + +H+G+ D++T +K + + Sbjct: 257 LLVADEVVTGFGRLGTMFGSDHYGIK--PDLITIAKGLTS 294 >6ERK-A nrPDB Length = 451 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 72/300 (24%), Positives = 119/300 (39%), Gaps = 59/300 (19%) Query: 78 EESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPAL-VKLVQQPQNVSTFI-----NRPAL 131 + + G Y+V DG R++D S + GY+HP L +++Q ++ + ++PA+ Sbjct: 51 DRAEGIYIVTEDGTRLIDGMSSWWASVHGYNHPKLNAAMIEQLGKMAHVMFGGLTHQPAI 110 Query: 132 GILPPENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSK 191 L + LLS+ P G+ + GS + E A K + + +R Sbjct: 111 ----------DLGKKLLSIVPAGLDAIFYADSGSIAVEVALKMALQYQIAAKRPSKC--- 157 Query: 192 EELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRL 251 S ++G T ++ PI L Sbjct: 158 -----------------QFASTHSGYYGDTWHAMSVCD--------------PINGMHSL 186 Query: 252 ---KYPLEEFVKENQQEEARCL--EEVEDLIVKYRKKKKTVAGIIVEPI-QSEGGDNHAS 305 + P++ FV R L E E L + K +AG I+EPI Q GG S Sbjct: 187 YGKQLPMQHFVAAPPMGFERDLTQSEREALTEFFVKNSDKLAGFIIEPIIQGAGGMRFYS 246 Query: 306 DDFFRKLRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGFF 365 + + LR + ++ + DE+ TG G +GK +A EH + D+MT K +TGG+ Sbjct: 247 PQYLQLLRKLCDEYDVLLIADEIATGFGRSGKLFACEHAAIS--PDIMTIGKA-LTGGYM 303 >1S09-A nrPDB Length = 429 Score = 67.0 bits (162), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 66/289 (22%), Positives = 119/289 (41%), Gaps = 46/289 (15%) Query: 80 SRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGILPPENF 139 + G L+ DG R++D S + GY+HP L ++ + + + + P Sbjct: 32 AEGCELILSDGRRLVDGMSSWWAAIHGYNHPQLNAAMKSQIDAMSHVMFGGITHAPAIEL 91 Query: 140 VEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELETCMI 199 KL +++ P+ + + GS + E A K ++++K + F Sbjct: 92 CRKL----VAMTPQPLECVFLADSGSVAVEVAMKMALQYWQAKGEARQRF---------- 137 Query: 200 NQAPGCPDYSILSFMGAFHGRTMGCLAT----THSKAIHKIDIPSFDWPIAPFPRLKYPL 255 L+F FHG T G ++ ++ K +P + AP R+ Sbjct: 138 -----------LTFRNGFHGDTFGAMSVCDPDNSMHSLWKGYLPENLFAPAPQSRMDGEW 186 Query: 256 EEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPI-QSEGGDNHASDDFFRKLRD 314 +E R + L+ +R + +A +I+EPI Q GG ++ +++R Sbjct: 187 DE----------RDMVGFARLMAAHRHE---IAAVIIEPIVQGAGGMRMYHPEWLKRIRK 233 Query: 315 ISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGG 363 I + G + DE+ TG G TGK +A EH + D++ K +TGG Sbjct: 234 ICDREGILLIADEIATGFGRTGKLFACEH--AEIAPDILCLGKA-LTGG 279 >3HMU-A nrPDB Length = 472 Score = 65.9 bits (159), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 89/403 (22%), Positives = 166/403 (41%), Gaps = 75/403 (18%) Query: 80 SRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINR-------PALG 132 +RG +L D +G +LD + + + IGY L ++ + + N PA+ Sbjct: 44 ARGVWLNDSEGEEILDAMAGLWCVNIGYGRDELAEVAARQMRELPYYNTFFKTTHVPAIA 103 Query: 133 ILPPENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKE 192 L + L +AP ++ + GS +N+ + + ++++K Sbjct: 104 ----------LAQKLAELAPGDLNHVFFAGGGSEANDTNIRMVRTYWQNK---------- 143 Query: 193 ELETCMINQAPGCPDYS-ILSFMGAFHGRT-----MGCLATTHSKA-----IHKIDIPSF 241 G P+ + I+S A+HG T +G +A H+++ +H I+ P++ Sbjct: 144 -----------GQPEKTVIISRKNAYHGSTVASSALGGMAGMHAQSGLIPDVHHINQPNW 192 Query: 242 DWPIAPFPRLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGD 301 W EEF AR E+E+ I++ + + VA I EP+Q GG Sbjct: 193 -WAEGG----DMDPEEF----GLARAR---ELEEAILELGENR--VAAFIAEPVQGAGGV 238 Query: 302 NHASDDFFRKLRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMT 361 A D ++ +++ I K+ + DEV G G TG ++ + G+ +MT +K + + Sbjct: 239 IVAPDSYWPEIQRICDKYDILLIADEVICGFGRTGNWFGTQTMGIR--PHIMTIAKGLSS 296 Query: 362 -----GGFFHKEEFRPNAPYRIFN---TWLGDPSKNLLLAEVINIIKREDLLSNAAHAGK 413 GG +E FN T+ G P + E + I++ E++L + + Sbjct: 297 GYAPIGGSIVCDEVAHVIGKDEFNHGYTYSGHPVAAAVALENLRILEEENILDHVRNVAA 356 Query: 414 VLLTGLLDLQARYPQFISRVRGRGTFCSFD-TPDESIRNKLIS 455 L + +P + + G S TP+++ R K S Sbjct: 357 PYLKEKWEALTDHP-LVGEAKIVGMMASIALTPNKASRAKFAS 398 >4BA4-A nrPDB Length = 459 Score = 62.0 bits (149), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 68/289 (23%), Positives = 119/289 (41%), Gaps = 40/289 (13%) Query: 80 SRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGILPPENF 139 G YL D +GN+++D + + + +GY + ++ F N P Sbjct: 39 GEGVYLWDSEGNKIIDGMAGLWCVNVGYGRKDFAEAARRQMEELPFYNTFFKTTHPA--- 95 Query: 140 VEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELETCMI 199 V +L L V P G ++ GS S + + + ++ + K E +T Sbjct: 96 VVELSSLLAEVTPAGFDRVFYTNSGSESVDTMIRMVRRYWDVQ-------GKPEKKT--- 145 Query: 200 NQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPL-EEF 258 ++ +HG T+G + K +H+ D PI ++ P + Sbjct: 146 ----------LIGRWNGYHGSTIGGASLGGMKYMHE----QGDLPIPGMAHIEQPWWYKH 191 Query: 259 VKENQQEE-----ARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLR 313 K+ +E AR LEE I++ K VA + EPIQ GG ++ ++ Sbjct: 192 GKDMTPDEFGVVAARWLEE---KILEIGADK--VAAFVGEPIQGAGGVIVPPATYWPEIE 246 Query: 314 DISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTG 362 I RK+ + DEV G G TG+++ H+H+G D+ T +K + +G Sbjct: 247 RICRKYDVLLVADEVICGFGRTGEWFGHQHFGFQ--PDLFTAAKGLSSG 293 >5UC7-A nrPDB Length = 431 Score = 60.8 bits (146), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 63/288 (21%), Positives = 117/288 (40%), Gaps = 40/288 (13%) Query: 78 EESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGILPPE 137 E + G L+ G R++D S + GY+HP L ++ + + + + P Sbjct: 32 ERAEGCELILSGGERLVDGMSSWWAAIHGYNHPQLNAAMKTQIDAMSHVMFGGITHAPAI 91 Query: 138 NFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELETC 197 KL +++ P + + GS + E A K ++++K + F Sbjct: 92 ELCRKL----VAMTPAPLECVFLADSGSVAVEVAMKMALQYWQAKGESRQRF-------- 139 Query: 198 MINQAPGCPDYSILSFMGAFHGRTMGCLATTHS-KAIHKIDIPSFDWPIAPFPRLKYPLE 256 L+F +HG T G ++ ++H + W L P Sbjct: 140 -------------LTFRNGYHGDTFGAMSVCDPHNSMHSL------WKGYLAENLFAPAP 180 Query: 257 EFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPI-QSEGGDNHASDDFFRKLRDI 315 + + +E R + L+ +R + +A +I+EPI Q GG + +++R + Sbjct: 181 QSRMGGEWDE-RDMVAFARLMAAHRHE---IAAVILEPIVQGAGGMRIYHPQWLQRIRQM 236 Query: 316 SRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGG 363 + G + DE+ TG G TG+ +A EH G+ D++ K +TGG Sbjct: 237 CDREGILLIADEIATGFGRTGRLFACEHAGIAP--DILCLGKA-LTGG 281 >5DDW-A nrPDB Length = 523 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 54/246 (21%), Positives = 102/246 (41%), Gaps = 11/246 (4%) Query: 211 LSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFVKENQQEEARCL 270 L+ G+FHG+ +G + T ++ + + P P + L + E+++ L Sbjct: 201 LTLDGSFHGKLVGSIQLTQNEP-WRTPFTALSSPARFLPADEPELIGKIVEDERRSVLTL 259 Query: 271 EEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDISRKHGCAFLVDEVQT 330 +D + + VA I VEP++ G + + +L + GC +VDEVQT Sbjct: 260 SLDKDTVRVVERDFPVVAAIFVEPVRGGSGMKTVTPELAEELHRLRDTLGCPLVVDEVQT 319 Query: 331 GGGSTGKFWAHEHWGLDDPADVMTFSKKMMTG------GFFHKEEFRPNAPYRIFNTWLG 384 G G TG F+ G+ D T +K + G ++ F P +T+ Sbjct: 320 GIGRTGAFFGSALLGIR--GDYYTLAKAIGGGIVKNSVALIRQDRFLPAMEVIHSSTFAK 377 Query: 385 DPSKNLLLAEVINIIKRED--LLSNAAHAGKVLLTGLLDLQARYPQFISRVRGRGTFCSF 442 D + +V+ +++ + + G+ L L ++A + +S V G G + Sbjct: 378 DGLSASIALKVLEMVEADGGRVYQRVRERGQRLEAMLESVRADHSDVVSAVWGTGLMLAL 437 Query: 443 DTPDES 448 + D+S Sbjct: 438 ELRDQS 443 >3DOD-A nrPDB Length = 448 Score = 57.4 bits (137), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 68/316 (21%), Positives = 133/316 (42%), Gaps = 49/316 (15%) Query: 142 KLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELETCMINQ 201 +L E+L+ ++PK ++++ G+ + E A K F ++++ Sbjct: 91 QLAETLIDISPKKLTRVFYSDSGAEAMEIALKMAFQYWKN-------------------- 130 Query: 202 APGCPD-YSILSFMGAFHGRTMGCLATTHSKAIHKIDIP-SFDWPIAPFPRLKYPLEEFV 259 G P+ ++ +HG T+G ++ + H + P F+ AP P Y Sbjct: 131 -IGKPEKQKFIAMKNGYHGDTIGAVSVGSIELFHHVYGPLMFESYKAPIP---YVYRSES 186 Query: 260 KENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEP-IQSEGGDNHASDDFFRKLRDISRK 318 + + +CL E+ L+ ++ ++ +A + +E +Q G + + +R++ Sbjct: 187 GDPDECRDQCLRELAQLLEEHHEE---IAALSIESMVQGASGMIVMPEGYLAGVRELCTT 243 Query: 319 HGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGFFH-KEEFRPNAPYR 377 + +VDEV TG G TGK +A EH + D+M + K +TGG+ F Y+ Sbjct: 244 YDVLMIVDEVATGFGRTGKMFACEHENVQ--PDLMA-AGKGITGGYLPIAVTFATEDIYK 300 Query: 378 IF-------------NTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDLQA 424 F +++ G+ + E + + + E+++ A K L L DL A Sbjct: 301 AFYDDYENLKTFFHGHSYTGNQLGCAVALENLALFESENIVEQVAEKSKKLHFLLQDLHA 360 Query: 425 RYPQFISRVRGRGTFC 440 P + +R G C Sbjct: 361 -LPH-VGDIRQLGFMC 374 >4WYG-A nrPDB Length = 457 Score = 55.5 bits (132), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 66/277 (23%), Positives = 107/277 (38%), Gaps = 47/277 (16%) Query: 93 MLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGILPPENFVEKLRESLLSVAP 152 +LD S + G+ HPAL + + V +N G L E +L + L+ + P Sbjct: 77 VLDAMSSWWTAIHGHGHPALDQALTTQLRV---MNHVMFGGLTHEP-AARLAKLLVDITP 132 Query: 153 KGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELETCMINQAPGCPDYSILS 212 G+ + GS S E A K ++R G+ K L ++ Sbjct: 133 AGLDTVFFSDSGSVSVEVAAKMALQYWR----GRGLPGKRRL----------------MT 172 Query: 213 FMGAFHGRTMGCLATTHSKA-IHKI--DIPSFDWPIAPFPRLKYPLEEFVKENQQEEARC 269 + G +HG T ++ +H + D+ + PR P E Q + Sbjct: 173 WRGGYHGDTFLAMSICDPHGGMHSLWTDVLAAQVFAPQVPRDYDPAYSAAFEAQLAQ--- 229 Query: 270 LEEVEDLIVKYRKKKKTVAGIIVEPI-QSEGGDNHASDDFFRKLRDISRKHGCAFLVDEV 328 +A ++VEP+ Q GG + LRDI R++ + DE+ Sbjct: 230 -------------HAGELAAVVVEPVVQGAGGMRFHDPRYLHDLRDICRRYEVLLIFDEI 276 Query: 329 QTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGFF 365 TG G TG +A +H G+ D+M K +TGG+ Sbjct: 277 ATGFGRTGALFAADHAGVSP--DIMCVGKA-LTGGYL 310 >4UHN-A nrPDB Length = 468 Score = 55.5 bits (132), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 70/327 (21%), Positives = 123/327 (37%), Gaps = 46/327 (14%) Query: 53 PRSRELMKQLNIIQNAEA--------VHFFCNYE---------ESRGNYLVDVDGNRMLD 95 PR + +Q+N+ +A A + F N + G++LVD G R+ D Sbjct: 16 PRGSHMNQQVNVAPSAAADLNLKAHWMPFSANRNFHKDPRIIVAAEGSWLVDDKGRRIYD 75 Query: 96 LYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGILPPENFVEKLRESLLSVAPKGM 155 S + + G+S + V + + T P P +F +L E + + P + Sbjct: 76 SLSGLWTCGAGHSRKEIADAVAK--QIGTLDYSPGFQYGHPLSF--QLAEKIAQMTPGTL 131 Query: 156 SQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELETCMINQAPGCPDYSILSFMG 215 + GS + + K ++R K + Q +T +I +A G Sbjct: 132 DHVFFTGSGSECADTSIKMARAYWRIKGQAQ--------KTKLIGRARG----------- 172 Query: 216 AFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFVKENQQEEARCLEEVED 275 +HG + + K+ P D + P P F K + L E Sbjct: 173 -YHGVNVAGTSLGGIGGNRKMFGPLMD--VDHLPHTLQPGMAFTKGAAETGGVELAN-EL 228 Query: 276 LIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDISRKHGCAFLVDEVQTGGGST 335 L + +A +IVEP+ G + ++LR+I + + DEV T G Sbjct: 229 LKLIELHDASNIAAVIVEPMSGSAGVIVPPKGYLQRLREICDANDILLIFDEVITAFGRM 288 Query: 336 GKFWAHEHWGLDDPADVMTFSKKMMTG 362 GK E++G+ D+M +K++ G Sbjct: 289 GKATGAEYFGVT--PDIMNVAKQVTNG 313 >5KQU-A nrPDB Length = 479 Score = 55.1 bits (131), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 78/385 (20%), Positives = 140/385 (36%), Gaps = 57/385 (14%) Query: 80 SRGNYLVDVDGNRMLDLYSQISSIPIGYSHP----ALVKLVQQPQNVSTFINRPALGILP 135 + G + D +G ++D ++ + + IGY A+ K ++ T++ Sbjct: 58 ASGIRIRDHEGRELIDAFAGLYCVNIGYGRTEVADAIYKQAKELAYYHTYVGHST----- 112 Query: 136 PENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELE 195 E +E + AP GM ++ GS +NE K + + R Q Sbjct: 113 -EAIIELSSRIIRDWAPAGMKKVYYGLSGSDANETQIKLVRYYNNVLGRPQKK------- 164 Query: 196 TCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPL 255 I+S +HG + + T + H+ FD P+ P Sbjct: 165 -------------KIISRQRGYHGSGIMTGSLTGLPSFHQ----HFDLPVEGIKHTVCPH 207 Query: 256 EEFVKENQQEEA---RCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKL 312 E A C +E+E LI+ + TVA I EP+ GG ++ + Sbjct: 208 WYKAPAGMDEAAFVRYCADELEKLILA--EGPDTVAAFIGEPVMGTGGIIVPPKGYWEAI 265 Query: 313 RDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTG---------- 362 + + K+ + DEV G G + +G+ D++T +K + + Sbjct: 266 QAVLNKYDVLLIADEVVCAFGRLGSKMGSQRYGMR--PDLITTAKGLTSAYAPLSAVIVG 323 Query: 363 ----GFFHKEEFRPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTG 418 K + A + T+ G P ++I++RE+L +NAA G L Sbjct: 324 EKVWDVIEKASQKEGAMGHGW-TYSGHPICAAAALANLDILERENLTANAADVGAYLNQR 382 Query: 419 LLDLQARYPQFISRVRGRGTFCSFD 443 L + +P + VRG G + + Sbjct: 383 LRETFEGHP-LVGEVRGDGMLAALE 406 >5G0A-A nrPDB Length = 483 Score = 54.7 bits (130), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 53/243 (21%), Positives = 103/243 (42%), Gaps = 39/243 (16%) Query: 271 EEVEDLIVKYRKKK------KTVAGIIVEPIQSEGGDNHASDDFFRKLRDISRKHGCAFL 324 E E L VKY ++ + VA +I E Q G ++ ++R ++++ G ++ Sbjct: 209 ENGELLSVKYTRRMIENYGPEQVAAVITEVSQG-AGSAMPPYEYIPQIRKMTKELGVLWI 267 Query: 325 VDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMT-----GGFFHKEE---FRPNAPY 376 DEV TG G TGK++ ++H+G+ D++T K + + G +E F + Sbjct: 268 NDEVLTGFGRTGKWFGYQHYGVQ--PDIITMGKGLSSSSLPAGAVLVSKEIAAFMDKHRW 325 Query: 377 RIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDLQARYPQFISRVRGR 436 +T+ G P + + ++ E+ + A +G+ + + L LQ ++ + I G Sbjct: 326 ESVSTYAGHPVAMAAVCANLEVMMEENFVEQAKDSGEYIRSKLELLQEKH-KSIGNFDGY 384 Query: 437 GTFCSFDTPDESIRNKLISIARN---------------------KGVMLGGCGDKSIRFR 475 G D + + + + RN KGV++GG ++R Sbjct: 385 GLLWIVDIVNAKTKTPYVKLDRNFTHGMNPNQIPTQIIMKKALEKGVLIGGVMPNTMRIG 444 Query: 476 PTL 478 +L Sbjct: 445 ASL 447 Score = 30.8 bits (68), Expect = 1.6, Method: Compositional matrix adjust. Identities = 12/49 (24%), Positives = 28/49 (57%) Query: 78 EESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFI 126 E + G+YL+ DG R+LD ++Q+ + +G + + +++ + F+ Sbjct: 37 ESTEGDYLIMPDGTRLLDFFNQLYCVNLGQKNQKVNAAIKEALDRYGFV 85 >3A8U-X nrPDB Length = 449 Score = 53.5 bits (127), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 66/311 (21%), Positives = 125/311 (40%), Gaps = 37/311 (11%) Query: 80 SRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGILPPENF 139 + G++LVD G ++ D S + + G++ + + V + +ST P P +F Sbjct: 39 AEGSWLVDDKGRKVYDSLSGLWTCGAGHTRKEIQEAVAK--QLSTLDYSPGFQYGHPLSF 96 Query: 140 VEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELETCMI 199 +L E + + P ++ + GS A K + ++R K GQ+ +T MI Sbjct: 97 --QLAEKITDLTPGNLNHVFFTDSGSECALTAVKMVRAYWRLK--GQAT------KTKMI 146 Query: 200 NQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPL---E 256 +A G +HG + + K+ F P+ L + L Sbjct: 147 GRARG------------YHGVNIAGTSLGGVNGNRKL----FGQPMQDVDHLPHTLLASN 190 Query: 257 EFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDIS 316 + + +E L + E L + +A + VEP+ G + + ++ R+I Sbjct: 191 AYSRGMPKEGGIALAD-ELLKLIELHDASNIAAVFVEPLAGSAGVLVPPEGYLKRNREIC 249 Query: 317 RKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGFFHKEEFRPNAPY 376 +H + DEV TG G TG + + +G+ D+M +K++ G A Sbjct: 250 NQHNILLVFDEVITGFGRTGSMFGADSFGVT--PDLMCIAKQVTNGAIPMGAVI---AST 304 Query: 377 RIFNTWLGDPS 387 I+ T++ P+ Sbjct: 305 EIYQTFMNQPT 315 >2CFB-A nrPDB Length = 411 Score = 52.0 bits (123), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 79/383 (20%), Positives = 134/383 (34%), Gaps = 73/383 (19%) Query: 77 YEESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGILPP 136 ++ +G ++ DVDGN+ +D +G++HP ++ + T P L Sbjct: 22 FDHVKGAHIWDVDGNQYIDYVGSWGPAIVGHAHPEVIDALHAALEKGTSFGAPCL----L 77 Query: 137 ENFVEKLRESLLSVAPK-GMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELE 195 EN L E +++ P M + + +C A + Y +E+ Sbjct: 78 ENI---LAEMVIAAVPSVEMVRFVNSGTEACM---AVLRLMRAYTQREK----------- 120 Query: 196 TCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAP-FPRLKYP 254 ++ F G +HG L S + + P +P P+ Sbjct: 121 --------------VIKFEGCYHGHADMFLVKAGS------GVATLGLPDSPGVPKATTA 160 Query: 255 LEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRD 314 N LE V L +Y +AG+I+EP+ G F LR+ Sbjct: 161 ATLTAPYND------LEAVSRLFEQY---PNDIAGVILEPVVGNAGFIPPDAGFLEGLRE 211 Query: 315 ISRKHGCAFLVDEVQTG-----GGSTGKFWAHEHWGLDDPADVMTFSK----KMMTGGFF 365 +++++G + DEV TG GG A E +G+ D+ T K + G + Sbjct: 212 LTKQYGALLVFDEVMTGFRIAYGG------AQEKFGVTP--DLTTLGKVIGGGLPVGAYG 263 Query: 366 HKEEF----RPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLD 421 + E P P T G+P + + I+ R + L+ GLLD Sbjct: 264 GRAEIMKMVAPAGPVYQAGTLSGNPLAMTAGIKTLEILSRPGSYEHLDRITGKLVQGLLD 323 Query: 422 LQARYPQFISRVRGRGTFCSFDT 444 + + G F F T Sbjct: 324 AAREFGHEVCGGHISGMFGLFFT 346 >2EPJ-A nrPDB Length = 434 Score = 51.2 bits (121), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 69/283 (24%), Positives = 112/283 (39%), Gaps = 52/283 (18%) Query: 82 GNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGILPPENFVE 141 G YL VDG R++DL + +G+ HP +++ V++ + R L P E V Sbjct: 47 GAYLYTVDGARIVDLVLAYGPLILGHKHPRVLEAVEEA------LARGWLYGAPGEAEVL 100 Query: 142 KLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELETCMINQ 201 + L V GM + + S A T R ++ +L Sbjct: 101 LAEKILGYVKRGGMIRFVN------SGTEATMTAIRLARG-------YTGRDL------- 140 Query: 202 APGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFVKE 261 IL F G +HG L S A H +P+ A P L Sbjct: 141 --------ILKFDGCYHGSHDAVLVAAGSAAAH-YGVPTS----AGVPEAVARLTLVTPY 187 Query: 262 NQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDISRKHGC 321 N +E +E + +Y + +AG+IVEP+ + G +F L+ +SR+ G Sbjct: 188 ND------VEALERVFAEYGDR---IAGVIVEPVIANAGVIPPRREFLAALQRLSRESGA 238 Query: 322 AFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGF 364 ++DEV T G G A ++ ++ D++ K++ GGF Sbjct: 239 LLILDEVVT-GFRLGLEGAQGYFNIE--GDIIVLG-KIIGGGF 277 >5I92-A nrPDB Length = 435 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 84/340 (24%), Positives = 123/340 (36%), Gaps = 73/340 (21%) Query: 77 YEESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGILPP 136 ++ + G Y++D D R +D + +G+SHP ++ V++ Sbjct: 44 FKHAEGAYVLDEDDKRYVDYVGSWGPMILGHSHPDVLDAVRR------------------ 85 Query: 137 ENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELET 196 +L L AP + + MA CS + + + M E SA Sbjct: 86 -----QLDHGLSYGAPTALE--VEMADLVCSMVPSMEMVRMVSSGTEATMSA-------- 130 Query: 197 CMINQAPGCPDY-SILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPL 255 I A G SI+ F G +HG + L S A+ +P + P P K+ L Sbjct: 131 --IRLARGYTGRDSIIKFEGCYHGHSDSLLVKAGSGAL-TFGVP--NSPGVPAAFAKHTL 185 Query: 256 EEFVKENQQEEAR-CLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRD 314 + N E R L EV K VA IIVEP+ + F LR+ Sbjct: 186 T--LPFNDIEAVRKTLGEV----------GKEVACIIVEPVAGNMNCVPPAPGFLEGLRE 233 Query: 315 ISRKHGCAFLVDEVQTG-----GGSTGKFWAHEHWGLDDPADVMTFSK----KMMTGGFF 365 +HG + DEV TG GG A ++G+ D+ TF K M G F Sbjct: 234 ACDEHGVVLIFDEVMTGFRVALGG------AQAYYGVT--PDLSTFGKIIGGGMPVGAFG 285 Query: 366 HKEE----FRPNAPYRIFNTWLGDPSKNLLLAEVINIIKR 401 K E P P T G+P + +I R Sbjct: 286 GKREIMQQISPLGPVYQAGTLSGNPLAMAAGLTTLRLISR 325 >3I5T-A nrPDB Length = 476 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 64/286 (22%), Positives = 111/286 (38%), Gaps = 35/286 (12%) Query: 80 SRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGILPPENF 139 + G Y+ DG R++D + + +GY +V + V + + + P Sbjct: 43 AEGIYVHTEDGRRLIDGPAGMWCAQVGYGRREIVDAMAHQAMVLPYASPWYMATSP---- 98 Query: 140 VEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELETCMI 199 +L E + ++ P ++++ GS + ++A + FS+ Sbjct: 99 AARLAEKIATLTPGDLNRIFFTTGGSTAVDSALR---------------FSE------FY 137 Query: 200 NQAPGCPDYS-ILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEF 258 N G P I+ +HG T A T + P+FD L P Sbjct: 138 NNVLGRPQKKRIIVRYDGYHGSTALTAACTGRTG----NWPNFDIAQDRISFLSSPNPRH 193 Query: 259 VKENQQEE--ARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDIS 316 QE ++E ED I T+A + EPI + GG + + + I Sbjct: 194 AGNRSQEAFLDDLVQEFEDRIESL--GPDTIAAFLAEPILASGGVIIPPAGYHARFKAIC 251 Query: 317 RKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTG 362 KH ++ DEV TG G G+++A E P D++TF+K + +G Sbjct: 252 EKHDILYISDEVVTGFGRCGEWFASEKVFGVVP-DIITFAKGVTSG 296 >4BQ0-A nrPDB Length = 448 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 56/283 (19%), Positives = 111/283 (39%), Gaps = 29/283 (10%) Query: 80 SRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGILPPENF 139 + G++L D G ++ D S + + G+S + + V + + T P P +F Sbjct: 40 AEGSWLTDDKGRKVYDSLSGLWTCGAGHSRKEIQEAVAR--QLGTLDYSPGFQYGHPLSF 97 Query: 140 VEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELETCMI 199 +L E + + P ++ + GS + + K ++R K + Q +T +I Sbjct: 98 --QLAEKIAGLLPGELNHVFFTGSGSECADTSIKMARAYWRLKGQPQ--------KTKLI 147 Query: 200 NQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFV 259 +A G ++ G ++G + +D+ + P + + Sbjct: 148 GRARGYHGVNVA-------GTSLGGIGGNRKMFGQLMDVDHLPHTLQPGMAFTRGMAQTG 200 Query: 260 KENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDISRKH 319 E L E+ D +A +IVEP+ G + ++LR+I +H Sbjct: 201 GVELANELLKLIELHD--------ASNIAAVIVEPMSGSAGVLVPPVGYLQRLREICDQH 252 Query: 320 GCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTG 362 + DEV T G G + E++G+ D+M +K++ G Sbjct: 253 NILLIFDEVITAFGRLGTYSGAEYFGVT--PDLMNVAKQVTNG 293 >3L44-A nrPDB Length = 434 Score = 49.3 bits (116), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 84/384 (21%), Positives = 136/384 (35%), Gaps = 73/384 (19%) Query: 78 EESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRP-ALGILPP 136 E +G Y DVDGN+ +D + I G++HP + K + P AL + Sbjct: 42 ERGKGAYFWDVDGNKYIDYLAAYGPIITGHAHPHITKAITTAAENGVLYGTPTALEV--- 98 Query: 137 ENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELET 196 F + L+E+ M L + + E TI + R + +K Sbjct: 99 -KFAKMLKEA--------MPALDKVRFVNSGTEAVMTTIRV-----ARAYTGRTK----- 139 Query: 197 CMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLE 256 I+ F G +HG + L S PS L P Sbjct: 140 -------------IMKFAGCYHGHSDLVLVAAGSG-------PS---------TLGTPDS 170 Query: 257 EFVKENQQEEARCL--EEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRD 314 V ++ +E + VE L K VA I+VEPI G F K+ + Sbjct: 171 AGVPQSIAQEVITVPFNNVETLKEALDKWGHEVAAILVEPIVGNFGIVEPKPGFLEKVNE 230 Query: 315 ISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADV---MTFSKKMMTGG-----FFH 366 + + G + DEV T + + G D V +T K++ GG + Sbjct: 231 LVHEAGALVIYDEVITA-------FRFMYGGAQDLLGVTPDLTALGKVIGGGLPIGAYGG 283 Query: 367 K----EEFRPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDL 422 K E+ P P T G+P+ + ++++E L G L G+L+ Sbjct: 284 KKEIMEQVAPLGPAYQAGTMAGNPASMASGIACLEVLQQEGLYEKLDELGATLEKGILEQ 343 Query: 423 QARYPQFISRVRGRGTFCSFDTPD 446 A++ I+ R +G + T + Sbjct: 344 AAKHNIDITLNRLKGALTVYFTTN 367 >5KQT-A nrPDB Length = 479 Score = 48.9 bits (115), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 75/384 (19%), Positives = 137/384 (35%), Gaps = 55/384 (14%) Query: 80 SRGNYLVDVDGNRMLDLYSQISSIPIGYSH----PALVKLVQQPQNVSTFINRPALGILP 135 + G + D G +LD ++ + + IGY A+ + +Q T++ + Sbjct: 58 ASGVRIRDHQGRELLDAFAGLYCVNIGYGRLEVADAIHEQAKQLAYYHTYVGHAS----- 112 Query: 136 PENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELE 195 E +E + AP GM ++ GS +NE K + + R Q Sbjct: 113 -EAIIELSARIIRDWAPAGMKKVYYGLSGSDANETQVKLVRYYNNVLGRPQKK------- 164 Query: 196 TCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPL 255 I+S +HG + + T + H+ FD P+ P Sbjct: 165 -------------KIISRQRGYHGSGIVTGSLTGLASFHQ----HFDLPVEGVKHTLCPH 207 Query: 256 EEFVKENQQEEA---RCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKL 312 E A C +E+E+LI+ + TVA I EP+ GG ++ + Sbjct: 208 FYKAPAGMDEAAFVRHCAQELENLILA--EGPDTVAAFIGEPVMGTGGIIVPPKGYWEAI 265 Query: 313 RDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGFFHKEEFRP 372 + + K+ + DEV G G + + D++T +K + + Sbjct: 266 QAVLAKYDVLLIADEVVCAFGRLGDKMGSQRHAMRP--DLITTAKGLTSAYAPLSAVIVG 323 Query: 373 NAPYRIFN-------------TWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGL 419 + + + T+ G P ++I++RE++ +NAA G L L Sbjct: 324 EKVWDVIDSASTREGAMGHGWTYSGHPICAAAALANLDILERENITANAADVGGYLNQQL 383 Query: 420 LDLQARYPQFISRVRGRGTFCSFD 443 +P + VRG G + + Sbjct: 384 RQAFEGHP-LVGEVRGDGMLAALE 406 >2E7U-A nrPDB Length = 424 Score = 48.5 bits (114), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 71/289 (24%), Positives = 111/289 (38%), Gaps = 65/289 (22%) Query: 82 GNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGILPPENFVE 141 G Y+ D DGNR LD + +G++HP ++ V+ E Sbjct: 43 GAYVWDADGNRYLDYVMSWGPLILGHAHPKVLARVR-----------------------E 79 Query: 142 KLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRS-KERGQSAFSKEELETCMIN 200 L L AP S L F + + S E SA + Sbjct: 80 TLERGLTFGAP---SPLEVALAKKVKRAYPFVDLVRFVNSGTEATMSALR-------LAR 129 Query: 201 QAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFVK 260 G P I+ F G +HG G L S A+ + +PS A P EE+ K Sbjct: 130 GYTGRP--YIVKFRGNYHGHADGLLVEAGSGAL-TLGVPS----SAGVP------EEYAK 176 Query: 261 ENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDISRKHG 320 E E + +++ +++ + +A II EP+ G ++DF + L + ++ +G Sbjct: 177 LTLVLEYNDPEGLREVL---KRRGEEIAAIIFEPVVGNAGVLVPTEDFLKALHE-AKAYG 232 Query: 321 CAFLVDEVQTG-----GGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGF 364 + DEV TG GG+T E GL D++T K++ GG Sbjct: 233 VLLIADEVMTGFRLAFGGAT------ELLGLKP--DLVTLG-KILGGGL 272 >3BS8-A nrPDB Length = 438 Score = 48.1 bits (113), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 57/255 (22%), Positives = 104/255 (40%), Gaps = 50/255 (19%) Query: 78 EESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGILPPE 137 E +G+ + D+DGN +D + +G+++ +V+ +++ T P E Sbjct: 48 ERGKGSKIFDIDGNEYIDYVLSWGPLILGHTNDRVVESLKKVAEYGTSFGAPT----EVE 103 Query: 138 NFVEKLRESLLSVAPKGMSQLITM-ACGSCSNENAFKTIFMWYRSKERGQSAFSKEELET 196 N + KL ++ P +++ M + G+ + +A + RG + +K Sbjct: 104 NELAKL---VIDRVPS--VEIVRMVSSGTEATMSALRL--------ARGYTGRNK----- 145 Query: 197 CMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLE 256 IL F G +HG L S + + +P D P P E Sbjct: 146 -------------ILKFEGCYHGHGDSLLIKAGS-GVATLGLP--DSPGVP--------E 181 Query: 257 EFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDIS 316 K LE V+ + +++ + +AG+IVEP+ G + F + LRDI+ Sbjct: 182 GIAKNTITVPYNDLESVK---LAFQQFGEDIAGVIVEPVAGNMGVVPPQEGFLQGLRDIT 238 Query: 317 RKHGCAFLVDEVQTG 331 ++G + DEV TG Sbjct: 239 EQYGSLLIFDEVMTG 253 >5HDM-A nrPDB Length = 434 Score = 43.1 bits (100), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 74/334 (22%), Positives = 120/334 (35%), Gaps = 72/334 (21%) Query: 81 RGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGILPPENFV 140 +G+ + D+DGN +D IG++ ++ + + T P L EN Sbjct: 49 KGSKMWDIDGNEYIDYVGSWGPAIIGHADDEVLAALAETMKKGTSFGAPCL----LENV- 103 Query: 141 EKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELETCMIN 200 L E ++S P I M S A + R AF+ +E Sbjct: 104 --LAEMVISAVPS-----IEMVRFVNSGTEACMGVLRLAR-------AFTNKE------- 142 Query: 201 QAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFVK 260 + F G +HG L S + + +P D P P + Sbjct: 143 --------KFIKFEGCYHGHANAFLVKAGS-GVATLGLP--DSPGVP--------KAATS 183 Query: 261 ENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDISRKHG 320 + LE VE L + K ++ +I+EP+ G + +F LR +++ +G Sbjct: 184 DTLTAPYNDLEAVEKLFAAH---KGEISAVILEPVVGNSGFIPPTPEFINGLRQLTKDNG 240 Query: 321 CAFLVDEVQTG-----GGSTGKFWAHEHWGLDDPADVMTFSKKMMTG---GFFHK----- 367 + DEV TG GG A E++G+ D+ T K + G G + Sbjct: 241 VLLIFDEVMTGFRLAYGG------AQEYFGIT--PDLTTLGKIIGGGLPVGAYGGRRDIM 292 Query: 368 EEFRPNAPYRIFNTWLGDPSKNLLLAEVINIIKR 401 E P P T G+P L + I+ +KR Sbjct: 293 EMVAPAGPMYQAGTLSGNP---LAMTAGIHTLKR 323 >4GSA-A nrPDB Length = 432 Score = 41.6 bits (96), Expect = 9e-04, Method: Compositional matrix adjust. Identities = 52/258 (20%), Positives = 93/258 (36%), Gaps = 54/258 (20%) Query: 77 YEESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRP-ALGILP 135 ++ + Y DVDGNR +D G++HP +++ ++ T P AL Sbjct: 43 FDRVKDAYAWDVDGNRYIDYVGTWGPAICGHAHPEVIEALKVAMEKGTSFGAPCAL---- 98 Query: 136 PEN-FVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEEL 194 EN E + +++ S+ M + + +C A + Y +++ Sbjct: 99 -ENVLAEMVNDAVPSIE---MVRFVNSGTEACM---AVLRLMRAYTGRDK---------- 141 Query: 195 ETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAP-FPRLKY 253 I+ F G +HG L S + + P +P P+ Sbjct: 142 ---------------IIKFEGCYHGHADMFLVKAGS------GVATLGLPSSPGVPK--- 177 Query: 254 PLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLR 313 K ++E + + + +AG+I+EPI G F LR Sbjct: 178 ------KTTANTLTTPYNDLEAVKALFAENPGEIAGVILEPIVGNSGFIVPDAGFLEGLR 231 Query: 314 DISRKHGCAFLVDEVQTG 331 +I+ +H + DEV TG Sbjct: 232 EITLEHDALLVFDEVMTG 249 >2CY8-A nrPDB Length = 453 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 18/61 (29%), Positives = 34/61 (55%) Query: 271 EEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDISRKHGCAFLVDEVQT 330 +++E + + +A I EP+ S G SD F R+ +++R++G F++DEV + Sbjct: 186 DDIEGMREVFANHGSDIAAFIAEPVGSHFGVTPVSDSFLREGAELARQYGALFILDEVIS 245 Query: 331 G 331 G Sbjct: 246 G 246 Score = 30.0 bits (66), Expect = 2.4, Method: Compositional matrix adjust. Identities = 11/32 (34%), Positives = 20/32 (62%) Query: 79 ESRGNYLVDVDGNRMLDLYSQISSIPIGYSHP 110 +++G + DVDGN LD + ++ +G+ HP Sbjct: 45 DAQGVHKTDVDGNVYLDFFGGHGALVLGHGHP 76 >4E77-A nrPDB Length = 429 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 58/254 (22%), Positives = 92/254 (36%), Gaps = 48/254 (18%) Query: 78 EESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGILPPE 137 E + G YL DVDG +D + +G++HPA+ Q V + R L P Sbjct: 40 ERADGAYLFDVDGKAYIDYVGSWGPMILGHNHPAI------RQAVIEAVER-GLSFGAPT 92 Query: 138 NFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELETC 197 K+ + + + P M + + G+ + +A + RG + K Sbjct: 93 EMEVKMAQLVTDLVPT-MDMVRMVNSGTEATMSAIRL--------ARGYTGRDK------ 137 Query: 198 MINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEE 257 I+ F G +HG L S A+ + P +P P + Sbjct: 138 ------------IIKFEGCYHGHADCLLVKAGSGAL------TLGQPNSP----GVP-TD 174 Query: 258 FVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDISR 317 F K L V +Y ++ VA IIVEP+ +F LR + Sbjct: 175 FAKHTLTCTYNDLASVRQAFEQYPQE---VACIIVEPVAGNMNCIPPLPEFLPGLRALCD 231 Query: 318 KHGCAFLVDEVQTG 331 + G ++DEV TG Sbjct: 232 EFGALLIIDEVMTG 245 >3K28-A nrPDB Length = 429 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 32/122 (26%), Positives = 52/122 (42%), Gaps = 14/122 (11%) Query: 210 ILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFVKENQQEEARC 269 IL F+G +HG L S + + +P D P P E V +N A Sbjct: 138 ILKFIGCYHGHGDSLLIKAGS-GVATLGLP--DSPGVP---------EGVAKNTITVA-- 183 Query: 270 LEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDISRKHGCAFLVDEVQ 329 ++E + + + +A +IVEP+ G F LR+++ ++G + DEV Sbjct: 184 YNDLESVKYAFEQFGDDIACVIVEPVAGNMGVVPPQPGFLEGLREVTEQNGALLIFDEVM 243 Query: 330 TG 331 TG Sbjct: 244 TG 245 >4ZM4-A nrPDB Length = 447 Score = 39.7 bits (91), Expect = 0.003, Method: Compositional matrix adjust. Identities = 23/85 (27%), Positives = 43/85 (50%), Gaps = 4/85 (4%) Query: 280 YRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDISRKHGCAFLVDEVQTGGGSTGKFW 339 + + +A +IVEP+ + G + F + LR+++ + G + DEV T G + Sbjct: 205 FARDGDRIAAVIVEPVLANAGVIPPAPGFLQLLRELTGRSGAMLVFDEVIT-GFRVARGG 263 Query: 340 AHEHWGLDDPADVMTFSKKMMTGGF 364 A E +G++ +T ++M GGF Sbjct: 264 AQERYGVEPD---LTVLSRVMGGGF 285 >4AOA-A nrPDB Length = 454 Score = 36.6 bits (83), Expect = 0.026, Method: Compositional matrix adjust. Identities = 62/320 (19%), Positives = 111/320 (34%), Gaps = 79/320 (24%) Query: 21 LVPGWRHISQAAAKVDVEFDYDGPLMKTEVPGPRSRELMKQLNII--QNAEAVHFFCNY- 77 LVP H++ AA + Y T+ R+ Q + N+ +V F+ + Sbjct: 14 LVPRGSHMTHAAIDQALADAYR---RFTDANPASQRQFEAQARYMPGANSRSVLFYAPFP 70 Query: 78 ---EESRGNYLVDVDGNRMLDLYSQISSIPIGYSHP----ALVKLVQQPQNVSTFINRPA 130 G L D DG+R D ++ ++ G+S P A+++ +Q N++ Sbjct: 71 LTIARGEGAALWDADGHRYADFIAEYTAGVYGHSAPEIRDAVIEAMQGGINLTG------ 124 Query: 131 LGILPPENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFS 190 N +E L+ + QL G+ +N A + ++ Sbjct: 125 ------HNLLEGRLARLICERFPQIEQLRFTNSGTEANLMALTAALHFTGRRK------- 171 Query: 191 KEELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPR 250 I+ F G +HG +G A + FD+ + P+ Sbjct: 172 -------------------IVVFSGGYHGGVLGFGARPSPTTV------PFDFLVLPY-- 204 Query: 251 LKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFR 310 N + AR + + +A ++VEP+Q G DF + Sbjct: 205 -----------NDAQTARA---------QIERHGPEIAVVLVEPMQGASGCIPGQPDFLQ 244 Query: 311 KLRDISRKHGCAFLVDEVQT 330 LR+ + + G + DEV T Sbjct: 245 ALRESATQVGALLVFDEVMT 264 >5YKR-A nrPDB Length = 461 Score = 34.7 bits (78), Expect = 0.100, Method: Compositional matrix adjust. Identities = 14/44 (31%), Positives = 25/44 (56%) Query: 287 VAGIIVEPIQSEGGDNHASDDFFRKLRDISRKHGCAFLVDEVQT 330 VA ++ EP + G ++ F LR+++R+H A ++DE T Sbjct: 220 VAAVLTEPFMTNVGMVPPAEGFHAGLRELTRRHDVALIIDETHT 263 >2YKV-A nrPDB Length = 465 Score = 32.7 bits (73), Expect = 0.33, Method: Compositional matrix adjust. Identities = 29/93 (31%), Positives = 41/93 (44%), Gaps = 7/93 (7%) Query: 270 LEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDISRKHGCAFLVDEVQ 329 +E DL+ ++ A I+VEP+ GG A F LR + + G + DEV Sbjct: 220 VEGTADLL---KRHGHDCAAILVEPMLGAGGCVPAERAFLDLLRAEASRCGALLIFDEVM 276 Query: 330 TGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTG 362 T S G A E G+ AD+ T K + G Sbjct: 277 TSRLSGG--GAQEMLGIS--ADLTTLGKYIGGG 305 >3WY7-A nrPDB Length = 404 Score = 32.0 bits (71), Expect = 0.65, Method: Compositional matrix adjust. Identities = 34/114 (29%), Positives = 49/114 (42%), Gaps = 18/114 (15%) Query: 281 RKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDISRKHGCAFLVDEVQTGG--GSTGKF 338 R +++ V ++ E + S GD R L + R+HG LVDE G G+ G+ Sbjct: 183 RTEERAV--VVTESVFSADGDLAP----LRDLHAVCRRHGALLLVDEAHGLGVRGTRGQG 236 Query: 339 WAHEHWGLDDPADVM---TFSKKMMT--GGFFHKEEFRP----NAPYRIFNTWL 383 HE GL D++ T SK + + G E R A IF+T L Sbjct: 237 LLHE-VGLAGAPDIVMTTTLSKALGSQGGAVLGPEAVRAHLIDTARSFIFDTGL 289 >4BMK-A nrPDB Length = 442 Score = 31.6 bits (70), Expect = 0.80, Method: Compositional matrix adjust. Identities = 33/98 (33%), Positives = 49/98 (50%), Gaps = 11/98 (11%) Query: 273 VEDLIVKYRKKKKTVAGIIV-EPIQSEGGDNHASDDFFRKLRDISRKHGCAFLVDEVQTG 331 VEDL + + K A ++V E + S GD +++ +++KHG LVDE + Sbjct: 202 VEDLDKRLGRLPKEPAKLVVLEGVYSMLGDIAP----LKEMVAVAKKHGAMVLVDEAHSM 257 Query: 332 G--GSTGKFWAHEHWGLDDPAD--VMTFSKKMMT-GGF 364 G G G+ +E GL+ D V TFS + T GGF Sbjct: 258 GFFGPNGR-GVYEAQGLEGQIDFVVGTFSASVGTVGGF 294 >6ED3-A nrPDB Length = 848 Score = 31.2 bits (69), Expect = 1.2, Method: Compositional matrix adjust. Identities = 16/55 (29%), Positives = 25/55 (45%) Query: 367 KEEFRPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLD 421 KEE P+ + + W G P+ LL E +++ ED L K +T + D Sbjct: 530 KEEVGPDDIADVVSAWTGIPAGRLLEGETAKLLRMEDELGKRVIGQKAAVTAVSD 584 >6CBN-A nrPDB Length = 438 Score = 30.4 bits (67), Expect = 2.0, Method: Compositional matrix adjust. Identities = 20/74 (27%), Positives = 34/74 (45%), Gaps = 10/74 (13%) Query: 276 LIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDISRKHGCAFLVDEVQTG---- 331 L+ + + + VA ++V P H S ++R+LR + G + DEV+ G Sbjct: 181 LLRELLRAPERVAAVVVSPDHM-----HLSPGWYRELRRLCSAAGVVLVADEVKVGLRYA 235 Query: 332 -GGSTGKFWAHEHW 344 G ST + A + W Sbjct: 236 PGLSTAELLAPDVW 249 >2B0C-A nrPDB Length = 206 Score = 30.0 bits (66), Expect = 2.4, Method: Compositional matrix adjust. Identities = 11/25 (44%), Positives = 18/25 (72%) Query: 82 GNYLVDVDGNRMLDLYSQISSIPIG 106 GN +VD+D NR+L +S ++ IP+ Sbjct: 15 GNVIVDIDFNRVLGAWSDLTRIPLA 39 >3RJP-A nrPDB Length = 96 Score = 29.6 bits (65), Expect = 3.0, Method: Composition-based stats. Identities = 17/59 (28%), Positives = 29/59 (49%), Gaps = 10/59 (16%) Query: 389 NLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDLQARY----------PQFISRVRGRG 437 N+L+ + ++ RE+LLSN + + T ++D+ RY +I VRG G Sbjct: 32 NILMTNMNRVMTREELLSNVWKYDEAVETNVVDVYIRYLRGKIDIPGKESYIQTVRGMG 90 >2X8U-A nrPDB Length = 412 Score = 29.6 bits (65), Expect = 3.5, Method: Compositional matrix adjust. Identities = 27/80 (33%), Positives = 40/80 (50%), Gaps = 10/80 (12%) Query: 290 IIVEPIQSEGGDNHASDDFFRKLRDISRKHGCAFLVDEVQTGG--GSTGKFWAHEHWGLD 347 +++E + S GD +++ +S+KHG LVDE G G G+ E G++ Sbjct: 178 VVLEGVYSMMGDIAP----LQEMVAVSKKHGAMILVDEAHGMGFFGEHGR-GVFEEAGVE 232 Query: 348 DPAD--VMTFSKKMMT-GGF 364 D V TFSK + T GGF Sbjct: 233 ADVDFVVGTFSKSVGTVGGF 252 >5XXB-B nrPDB Length = 389 Score = 29.6 bits (65), Expect = 3.6, Method: Compositional matrix adjust. Identities = 12/42 (28%), Positives = 23/42 (54%) Query: 151 APKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKE 192 P+G+ L+T+ G S+E + WY+SK + + ++K Sbjct: 95 TPRGLRALVTVWAGHLSDECKRRFYKNWYKSKRKAFTKYAKR 136 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 1OHW-A nrPDB 571 e-163 3R4T-A nrPDB 384 e-107 5KR6-A nrPDB 383 e-106 3OKS-A nrPDB 379 e-105 5KQW-A nrPDB 376 e-105 5KR3-A nrPDB 374 e-104 6IO1-A nrPDB 374 e-104 5TI8-A nrPDB 372 e-103 5KR5-A nrPDB 372 e-103 5VIU-A nrPDB 370 e-103 3N5M-A nrPDB 368 e-102 3Q8N-A nrPDB 365 e-101 2E54-A nrPDB 365 e-101 1SFF-A nrPDB 363 e-100 5GHG-A nrPDB 362 e-100 6G4F-A nrPDB 362 e-100 5KQU-A nrPDB 360 e-100 6GWI-A nrPDB 359 2e-99 2EH6-A nrPDB 355 4e-98 2EO5-A nrPDB 354 4e-98 1OAT-A nrPDB 354 4e-98 1Z7D-A nrPDB 354 5e-98 3NTJ-A nrPDB 352 1e-97 6FYQ-A nrPDB 352 2e-97 5LL2-A nrPDB 349 2e-96 3HMU-A nrPDB 348 3e-96 5X3F-A nrPDB 348 4e-96 4BA4-A nrPDB 343 1e-94 5KQT-A nrPDB 341 4e-94 3GJU-A nrPDB 340 1e-93 5LH9-A nrPDB 337 9e-93 3RUY-A nrPDB 333 8e-92 3FCR-A nrPDB 333 1e-91 5EAV-A nrPDB 332 3e-91 4FFC-A nrPDB 330 7e-91 1WKH-A nrPDB 330 1e-90 3DOD-A nrPDB 329 2e-90 4ADC-A nrPDB 327 7e-90 4E3Q-A nrPDB 325 3e-89 4UHN-A nrPDB 323 9e-89 4ATP-A nrPDB 323 1e-88 3NX3-A nrPDB 322 2e-88 4JF0-A nrPDB 322 3e-88 4GRX-A nrPDB 317 9e-87 2JJG-A nrPDB 316 1e-86 4BQ0-A nrPDB 312 3e-85 1ZOD-A nrPDB 310 1e-84 5M46-A nrPDB 305 3e-83 3I5T-A nrPDB 304 5e-83 4PPM-A nrPDB 304 6e-83 6GIO-D nrPDB 297 8e-81 2ZUK-A nrPDB 295 3e-80 5G4J-A nrPDB 291 5e-79 6ERK-A nrPDB 290 1e-78 5UC7-A nrPDB 290 1e-78 3A8U-X nrPDB 285 4e-77 1S09-A nrPDB 282 2e-76 5G0A-A nrPDB 275 3e-74 3I4J-A nrPDB 253 1e-67 3L44-A nrPDB 253 1e-67 2CFB-A nrPDB 250 1e-66 5DDW-A nrPDB 245 4e-65 4E77-A nrPDB 242 2e-64 4GSA-A nrPDB 239 2e-63 4WYG-A nrPDB 238 4e-63 3BS8-A nrPDB 236 1e-62 5I92-A nrPDB 231 4e-61 5HDM-A nrPDB 229 3e-60 2E7U-A nrPDB 226 2e-59 2EPJ-A nrPDB 207 7e-54 2CY8-A nrPDB 155 4e-38 Sequences not found previously or not previously below threshold: 3K28-A nrPDB 232 2e-61 4ZM4-A nrPDB 162 2e-40 4AOA-A nrPDB 147 1e-35 4A0G-A nrPDB 132 3e-31 2YKV-A nrPDB 130 1e-30 5YKR-A nrPDB 116 2e-26 5Z8A-A nrPDB 69 5e-12 6CBN-A nrPDB 60 1e-09 3WY7-A nrPDB 54 2e-07 3TQX-A nrPDB 53 2e-07 6HRH-B nrPDB 47 3e-05 1FC4-A nrPDB 45 6e-05 3HQT-A nrPDB 45 8e-05 1O4S-A nrPDB 44 1e-04 2BWN-A nrPDB 40 0.002 4WP0-A nrPDB 39 0.004 3FVS-A nrPDB 39 0.004 1V2E-A nrPDB 38 0.008 5TXT-B nrPDB 38 0.012 1GC4-A nrPDB 37 0.015 2CH1-A nrPDB 36 0.046 3LVM-A nrPDB 35 0.051 2X8U-A nrPDB 35 0.052 5YHV-A nrPDB 35 0.059 3O59-X nrPDB 35 0.071 5WGB-A nrPDB 35 0.072 4ISY-A nrPDB 35 0.092 5JAY-A nrPDB 34 0.15 5W1B-A nrPDB 34 0.18 2DR1-A nrPDB 34 0.19 4LF1-A nrPDB 34 0.22 5HH9-A nrPDB 33 0.26 3I4K-A nrPDB 33 0.32 4MY5-A nrPDB 33 0.33 1B85-A nrPDB 33 0.36 4EXQ-A nrPDB 32 0.44 3L8A-A nrPDB 32 0.50 6ONN-A nrPDB 32 0.56 4BMK-A nrPDB 32 0.56 3DZZ-A nrPDB 32 0.57 3F9T-A nrPDB 32 0.78 3B1C-A nrPDB 32 0.80 2HUU-A nrPDB 31 1.00 3LWS-A nrPDB 31 1.3 1M6S-A nrPDB 31 1.3 3E9K-A nrPDB 31 1.4 1LLP-A nrPDB 30 1.7 3NL2-A nrPDB 30 1.8 3KGX-A nrPDB 30 1.8 5BQK-A nrPDB 30 1.9 3WGB-A nrPDB 30 1.9 4JO5-A nrPDB 30 2.1 1BW0-A nrPDB 30 2.4 5VNX-A nrPDB 30 2.4 3ISL-A nrPDB 30 2.5 3UWC-A nrPDB 30 2.7 2Z1K-A nrPDB 30 2.8 6DEO-A nrPDB 30 3.0 1VJO-A nrPDB 30 3.3 2ZJG-A nrPDB 30 3.4 2EZ4-A nrPDB 30 3.4 1P0K-A nrPDB 29 3.8 4QR8-A nrPDB 29 3.9 2RUS-A nrPDB 29 4.5 1D4E-A nrPDB 29 4.6 1O89-A nrPDB 29 5.0 3KE3-A nrPDB 29 5.0 1GDE-A nrPDB 29 5.2 6E14-D nrPDB 29 5.7 1YDM-A nrPDB 29 5.7 1D2F-A nrPDB 29 5.9 2YRI-A nrPDB 29 6.6 5W4C-A nrPDB 29 6.8 2FQL-A nrPDB 29 7.0 4EB7-A nrPDB 29 7.1 5EJJ-A nrPDB 29 7.2 2ZYJ-A nrPDB 29 7.8 4CVQ-A nrPDB 28 9.4 >1OHW-A nrPDB Length = 472 Score = 571 bits (1472), Expect = e-163, Method: Composition-based stats. Identities = 472/472 (100%), Positives = 472/472 (100%) Query: 29 SQAAAKVDVEFDYDGPLMKTEVPGPRSRELMKQLNIIQNAEAVHFFCNYEESRGNYLVDV 88 SQAAAKVDVEFDYDGPLMKTEVPGPRSRELMKQLNIIQNAEAVHFFCNYEESRGNYLVDV Sbjct: 1 SQAAAKVDVEFDYDGPLMKTEVPGPRSRELMKQLNIIQNAEAVHFFCNYEESRGNYLVDV 60 Query: 89 DGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGILPPENFVEKLRESLL 148 DGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGILPPENFVEKLRESLL Sbjct: 61 DGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGILPPENFVEKLRESLL 120 Query: 149 SVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELETCMINQAPGCPDY 208 SVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELETCMINQAPGCPDY Sbjct: 121 SVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELETCMINQAPGCPDY 180 Query: 209 SILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFVKENQQEEAR 268 SILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFVKENQQEEAR Sbjct: 181 SILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFVKENQQEEAR 240 Query: 269 CLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDISRKHGCAFLVDEV 328 CLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDISRKHGCAFLVDEV Sbjct: 241 CLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDISRKHGCAFLVDEV 300 Query: 329 QTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGFFHKEEFRPNAPYRIFNTWLGDPSK 388 QTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGFFHKEEFRPNAPYRIFNTWLGDPSK Sbjct: 301 QTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGFFHKEEFRPNAPYRIFNTWLGDPSK 360 Query: 389 NLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDLQARYPQFISRVRGRGTFCSFDTPDES 448 NLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDLQARYPQFISRVRGRGTFCSFDTPDES Sbjct: 361 NLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDLQARYPQFISRVRGRGTFCSFDTPDES 420 Query: 449 IRNKLISIARNKGVMLGGCGDKSIRFRPTLVFRDHHAHLFLNIFSDILADFK 500 IRNKLISIARNKGVMLGGCGDKSIRFRPTLVFRDHHAHLFLNIFSDILADFK Sbjct: 421 IRNKLISIARNKGVMLGGCGDKSIRFRPTLVFRDHHAHLFLNIFSDILADFK 472 >3R4T-A nrPDB Length = 467 Score = 384 bits (986), Expect = e-107, Method: Composition-based stats. Identities = 116/470 (24%), Positives = 186/470 (39%), Gaps = 49/470 (10%) Query: 45 LMKTEVPGPRSRELMKQLNIIQNAE-AVHFFCNYEESRGNYLVDVDGNRMLDLYSQISSI 103 L+ TE+PGP S EL K+ + V + G + D DGNR++DL S I+ Sbjct: 31 LLVTEIPGPASLELNKRRAAAVSGGVGVTLPVFVVRAGGGIVEDADGNRLIDLGSGIAVT 90 Query: 104 PIGYSHPALVKLVQQPQNVSTFINRPALGILPPENFVEKLRESLLSVAPK-GMSQLITMA 162 IG S P +V V+ + P E +V + E L + P G + + Sbjct: 91 TIGNSAPRVVDAVRDQVEQ---FTHTCFMVTPYEQYVA-VAEQLNRITPGSGEKRTVLFN 146 Query: 163 CGSCSNENAFKTIFMWYRSKERGQSAFSKEELETCMINQAPGCPDYSILSFMGAFHGRTM 222 G+ + EN+ K R + +++F A+HGRT Sbjct: 147 SGAEAVENSIKVARAHTRKQA--------------------------VVAFDYAYHGRTN 180 Query: 223 GCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFVKENQQEEARCLEEVEDLIVKYRK 282 +A T +K F I P + + ++ + E ++ + Sbjct: 181 LTMALTAKSMPYKSGFGPFAPEIYRAPVSYPYRDNLLDKDIATDGELAAERAINLIDKQI 240 Query: 283 KKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDISRKHGCAFLVDEVQTGGGSTGKFWAHE 342 +A +I+EPI EGG +D F L+ R + F+ DEVQTG TG +A + Sbjct: 241 GAANLAAVIIEPIAGEGGFIVPADGFLPALQRWCRDNDVVFIADEVQTGFARTGAMFACD 300 Query: 343 HWGLDDPADVMTFSKKMMTGGFF-----HKEEFRPNAPYRIFNTWLGDPSKNLLLAEVIN 397 H ++ D++ +K + G E + T+ G+P I Sbjct: 301 HENVE--PDLIVTAKGIADGFPLSAVTGRAEIMDAPHTSGLGGTFGGNPVACAAALATIE 358 Query: 398 IIKREDLLSNAAHAGKVLLTGLLDLQARYPQFISRVRGRGTFCSFDT-------PDESIR 450 I+R+ ++ A ++++ LL LQA + VRGRG + + PD ++ Sbjct: 359 TIERDGMVERARQIERLVMDRLLRLQAADDRL-GDVRGRGAMIAMELVKSGTAEPDAALT 417 Query: 451 NKLISIARNKGVMLGGCG--DKSIRFRPTLVFRDHHAHLFLNIFSDILAD 498 KL + A GV++ CG IR P L D L+I ILAD Sbjct: 418 QKLAAAAHAAGVIVLTCGMFGNVIRLLPPLTISDELLSEGLDILCQILAD 467 >5KR6-A nrPDB Length = 479 Score = 383 bits (983), Expect = e-106, Method: Composition-based stats. Identities = 87/449 (19%), Positives = 161/449 (35%), Gaps = 61/449 (13%) Query: 80 SRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGILPPENF 139 +G + D +G +D ++ + + +GY + + + + + + Sbjct: 58 GKGIRIQDSEGREYIDAFAGLYCVNVGYGRTEIADAIYEQAKELAYYHT---YVGHSNEP 114 Query: 140 VEKLRESLLS-VAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELETCM 198 + +L E ++ AP GMS++ GS +NE K + WY + G+ K Sbjct: 115 IIELSERIIREWAPAGMSKVYYGMSGSDANETQIKLV--WYYNNVLGRPQKKK------- 165 Query: 199 INQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEF 258 I+S +HG + + T A H FD P+ P P Sbjct: 166 -----------IISRQRGYHGSGIMTGSLTGLPAFHN----HFDLPLEPIRHTTCPHYYR 210 Query: 259 VKENQQEEA---RCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDI 315 E C +E+E +I+ + TVA I EP+ GG + ++ ++ + Sbjct: 211 APAGMSEAEFSRHCADELEKMILA--EGPDTVAAFIGEPVMGTGGIVPPPEGYWEAIQAV 268 Query: 316 SRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTG-----GFFHKEEF 370 K+ + DEV G G TG + H+G+ D++T +K + + G E+ Sbjct: 269 LNKYDILLIADEVVCGFGRTGSMFGSHHYGMK--PDLITVAKGLTSAYAPLSGVIVGEKV 326 Query: 371 --------RPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDL 422 P T+ G P ++II+RE+L NAA G + + Sbjct: 327 WKVLEQGSDQYGPIGHGWTYSGHPICAAAALANLDIIERENLTGNAADTGAYFQQRMRET 386 Query: 423 QARYPQFISRVRGRGTFCSFDT-----------PDESIRNKLISIARNKGVMLGGC-GDK 470 +P + VRG G + + P + ++ + G++ Sbjct: 387 FGDHP-LVGEVRGVGLMAALEFVADKDKRTRFDPSLKVGPRVSAACLEDGMIARAMPHGD 445 Query: 471 SIRFRPTLVFRDHHAHLFLNIFSDILADF 499 + F P LV ++I + Sbjct: 446 ILGFAPPLVITRAEVDEIVDIAKQAVDAV 474 >3OKS-A nrPDB Length = 451 Score = 379 bits (972), Expect = e-105, Method: Composition-based stats. Identities = 116/467 (24%), Positives = 189/467 (40%), Gaps = 49/467 (10%) Query: 46 MKTEVPGPRSRELM-KQLNIIQNAEAVHFFCNYEESRGNYLVDVDGNRMLDLYSQISSIP 104 + T +PGPRS+ L+ ++ + + G + DVDGNR++DL S I+ Sbjct: 15 LATAIPGPRSQALIDRKGTAVARGVGTTMPVYAVRAGGGIVEDVDGNRLIDLGSGIAVTT 74 Query: 105 IGYSHPALVKLVQQPQNVSTFINRPALGILPPENFVEKLRESLLSVAP-KGMSQLITMAC 163 +G S P +V+ V+ V F + + + P E +V + E L + P +G + Sbjct: 75 VGNSAPKVVEAVRSQ--VGDFTHTCFM-VTPYEGYVA-VCEQLNRLTPVRGDKRSALFNS 130 Query: 164 GSCSNENAFKTIFMWYRSKERGQSAFSKEELETCMINQAPGCPDYSILSFMGAFHGRTMG 223 GS + ENA K ++++F A+HGRT Sbjct: 131 GSEAVENAVKIARSH--------------------------THKPAVVAFDHAYHGRTNL 164 Query: 224 CLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKK 283 +A T +K F I P + + + + ++ + Sbjct: 165 TMALTAKVMPYKDGFGPFAPEIYRAPLSYPFRDAEFGKELATDGELAAKRAITVIDKQIG 224 Query: 284 KKTVAGIIVEPIQSEGGDNHASDDFFRKLRDISRKHGCAFLVDEVQTGGGSTGKFWAHEH 343 +A +++EPIQ EGG +D F L D RK+ F+ DEVQTG TG +A EH Sbjct: 225 ADNLAAVVIEPIQGEGGFIVPADGFLPTLLDWCRKNDVVFIADEVQTGFARTGAMFACEH 284 Query: 344 WGLDDPADVMTFSKKMMTGGFF-----HKEEFRPNAPYRIFNTWLGDPSKNLLLAEVINI 398 G+D D++ +K + G E + T+ G+P I Sbjct: 285 EGID--PDLIVTAKGIAGGLPLSAVTGRAEIMDSPHVSGLGGTYGGNPIACAAALATIET 342 Query: 399 IKREDLLSNAAHAGKVLLTGLLDLQARYPQFISRVRGRGTFCSFDT-------PDESIRN 451 I+ E L++ A K++ L LQA + I VRGRG + + PD + Sbjct: 343 IESEGLVARAQQIEKIMKDRLGRLQAEDDR-IGDVRGRGAMIAMELVKAGTTEPDADLTK 401 Query: 452 KLISIARNKGVMLGGCG--DKSIRFRPTLVFRDHHAHLFLNIFSDIL 496 L + A GV++ CG +RF P L D + L++ ++L Sbjct: 402 ALCAGAHAAGVIVLSCGTYGNVVRFLPPLSIGDDLLNEGLDVLEEVL 448 >5KQW-A nrPDB Length = 479 Score = 376 bits (966), Expect = e-105, Method: Composition-based stats. Identities = 88/448 (19%), Positives = 158/448 (35%), Gaps = 59/448 (13%) Query: 80 SRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGILPPENF 139 +G + D +G +D ++ + + IGY + + + + + E Sbjct: 58 GKGIRIQDHEGREYIDAFAGLYCVNIGYGRTEVADAIYEQAKELAYYHT--YVGHSTEAI 115 Query: 140 VEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELETCMI 199 +E + AP GM ++ GS +NE K + WY + G+ K Sbjct: 116 IELSSRIIRDWAPAGMKKVYYGMSGSDANETQIKLV--WYYNNVLGRPQKKK-------- 165 Query: 200 NQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFV 259 I+S +HG + + T + H+ FD PI P Sbjct: 166 ----------IISRQRGYHGSGIMTGSLTGLPSFHQ----HFDLPIERIKHTVCPHWYKA 211 Query: 260 KENQQEEA---RCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDIS 316 E C +E+E LI+ + TVA I EP+ GG ++ ++ + Sbjct: 212 PAGMSEAQFVRYCADELEKLILA--EGPDTVAAFIGEPVMGTGGIIPPPQGYWEAIQAVL 269 Query: 317 RKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTG-----GFFHKEEF- 370 K+ + DEV G G G +H+G+ D++T +K + + G E+ Sbjct: 270 NKYDILLIADEVVCGFGRLGSKMGSQHYGMK--PDLITVAKGLTSAYAPLSGVIVGEKVW 327 Query: 371 -------RPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDLQ 423 + + P T+ G P ++I++RE+L NAA G L L + Sbjct: 328 DVIEKGSQEHGPMGHGWTYSGHPICAAAALANLDILERENLTGNAADVGAYLQQRLRETF 387 Query: 424 ARYPQFISRVRGRGTFCSFDT-----------PDESIRNKLISIARNKGVMLGGC-GDKS 471 +P + VRG G + + P + K+ + G++ Sbjct: 388 GGHP-LVGEVRGVGMLAALEFMADKDARTPFDPALKVGPKVSAACLEDGMIARAMPHGDI 446 Query: 472 IRFRPTLVFRDHHAHLFLNIFSDILADF 499 + F P LV + I + + Sbjct: 447 LGFAPPLVITRAEVDEIVGIAKQAVDEV 474 >5KR3-A nrPDB Length = 479 Score = 374 bits (961), Expect = e-104, Method: Composition-based stats. Identities = 92/448 (20%), Positives = 162/448 (36%), Gaps = 59/448 (13%) Query: 80 SRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGILPPENF 139 +G + D +G +D ++ + + IGY + + + + + + Sbjct: 58 GKGIRIEDHEGREYIDAFAGLYCVNIGYGRTEVADAIYEQAKQLAYYHT--YVGHSTDAI 115 Query: 140 VEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELETCMI 199 +E + AP GM ++ GS +NE K + WY + G+ K Sbjct: 116 IELSSRIIRDWAPAGMKKVYYGMSGSDANETQIKLV--WYYNNVLGRPNKKK-------- 165 Query: 200 NQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFV 259 I+S +HG + + T + H+ FD PI P Sbjct: 166 ----------IISRERGYHGSGIVTGSLTGLPSFHQ----HFDLPIDRVKHTVCPHWYRA 211 Query: 260 KENQQEE---ARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDIS 316 E A C+EE+E LI R+ T+A I EP+ GG ++ ++ + Sbjct: 212 PAGMSEAQFVAYCVEELEKLIA--REGADTIAAFIAEPVMGTGGIIPPPQGYWEAIQAVL 269 Query: 317 RKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTG-----GFFHKEEF- 370 RKH + DEV G G G +H+G+ D++T +K + + G E+ Sbjct: 270 RKHDILLIADEVVCGFGRLGSKMGSQHYGIK--PDLITVAKGLTSAYAPLSGVIVGEKVW 327 Query: 371 -------RPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDLQ 423 + + P T+ G P ++I++RE+L NAA G L L + Sbjct: 328 DVIEKGSQEHGPMGHGWTYSGHPICAAAALANLDILERENLTGNAADVGAYLQQRLHEAF 387 Query: 424 ARYPQFISRVRGRGTFCSFDT-----------PDESIRNKLISIARNKGVMLGGC-GDKS 471 +P + VRG G + + P + K+ + A G++ Sbjct: 388 GAHP-LVGEVRGVGMLAALEFMADKDARTPFDPALKVGPKVSAAALEDGMIARAMPHGDI 446 Query: 472 IRFRPTLVFRDHHAHLFLNIFSDILADF 499 + F P LV + I + + Sbjct: 447 LGFAPPLVTTRAEVDEIVGIAKQAVDEV 474 >6IO1-A nrPDB Length = 451 Score = 374 bits (960), Expect = e-104, Method: Composition-based stats. Identities = 103/450 (22%), Positives = 179/450 (39%), Gaps = 58/450 (12%) Query: 74 FCNYEESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGI 133 G ++ D +G R LD ++ + ++ IG+ L + ++ F+ Sbjct: 34 PLVLVRGEGVWVWDAEGKRYLDGFAGLWNVNIGHGRRELAEAAREQMERVAFVPTFFGLA 93 Query: 134 LPPENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEE 193 PP +L L + P + + G+ SNE A K ++ K + + Sbjct: 94 SPP---TIELAARLAELFPGPLDHFQFTSGGAESNETAIKIARYYWWLKGQPE------- 143 Query: 194 LETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKY 253 ILS A+HG MG L+ T A + F F L Sbjct: 144 -------------RVKILSRRMAYHGIAMGALSATGVPAYWE----GFGPRPPGFIHLTA 186 Query: 254 PLEEFVKENQQEE---ARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFR 310 P + E +E AR ++E+E+ I R+ +T+A I EP+Q GG D ++ Sbjct: 187 PYKYRFGEGLTDEEFVARLVQELEETIE--REGSETIAAFIGEPVQGAGGVVVPPDGYWP 244 Query: 311 KLRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMT-----GGFF 365 + + RK+G ++DEV TG G TG + + +G+ D++TF+K + + GG Sbjct: 245 AIAAVLRKYGILLILDEVITGFGRTGTLFGMQQYGVQ--PDIVTFAKGITSGYVPLGGVG 302 Query: 366 HKEEFR-----PNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLL 420 +E + + T+ G P + ++I+ E L NAA +G LL L Sbjct: 303 VSDEIAETLASADRVFMHGFTYSGHPVACAVALRNLDILLAERLWENAAASGAYLLQELK 362 Query: 421 DLQARYPQFISRVRGRGTFCSFDT-----------PDESIRNKLISIARNKGVMLGGCGD 469 L+ R ++ VRG+G + P+ + KL + R +G+++ C Sbjct: 363 RLEER--PYVGEVRGKGLMLLVEVVRDKASKEKFPPEFKLGPKLEAATRRRGIIVR-CTP 419 Query: 470 KSIRFRPTLVFRDHHAHLFLNIFSDILADF 499 I P L + + + L+D Sbjct: 420 DGIVMAPPLTISRAECDVLIEGVAAALSDV 449 >5TI8-A nrPDB Length = 474 Score = 372 bits (956), Expect = e-103, Method: Composition-based stats. Identities = 95/482 (19%), Positives = 177/482 (36%), Gaps = 68/482 (14%) Query: 53 PRSRELMKQLNI-------IQNAEAVHFFCNYE-----------ESRGNYLVDVDGNRML 94 PR + KQ + + + F +Y+ ++ G YL D +GN++L Sbjct: 16 PRGSHMTKQTSAQTQHWQALSREHHLAPFTDYKQLNEKGARIITKAEGVYLWDSEGNKIL 75 Query: 95 DLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGILPPENFVEKLRESLLSVAPKG 154 D + + + +GY L ++ + + N PP +L +++ +AP+G Sbjct: 76 DGMAGLWCMNVGYGRKELAEVAYKQMLELPYYNLFFQTAHPP---ALELAKAIADIAPEG 132 Query: 155 MSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELETCMINQAPGCPDYSILSFM 214 M+ + GS SN+ + + ++ K + Q ++ Sbjct: 133 MNHVFFTGSGSESNDTVLRMVRHYWSIKGKPQKKV--------------------VIGRW 172 Query: 215 GAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFVKENQQEEARCLEEVE 274 +HG T+ ++ KA+H D PI + P + E + E Sbjct: 173 NGYHGSTVAGVSLGGMKALHSQG----DLPIPGIVHIAQPYWYGEGGDMSAEEFGVWAAE 228 Query: 275 DLIVKYRK-KKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDISRKHGCAFLVDEVQTGGG 333 L K + ++ VA I EPIQ GG D ++ K+R+I K+ F+ DEV G G Sbjct: 229 QLEKKILEVGEENVAAFIAEPIQGAGGVIVPPDTYWPKIREILAKYEILFIADEVICGFG 288 Query: 334 STGKFWAHEHWGLDDPADVMTFSKKMMT-----GGFFHKEEFRP----NAPYRIFNTWLG 384 TG+++ +++G + D+M +K + + GG ++E + T+ G Sbjct: 289 RTGEWFGSQYYG--NAPDLMPIAKGLTSGYIPMGGVIVRDEIVDTLNEGGEFYHGFTYSG 346 Query: 385 DPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDLQARYPQFISRVRGRGTFCSFDT 444 P + E I I++ E ++ L A +P + RG G + + Sbjct: 347 HPVAAAVALENIRILREEKIVETVKAETAPYLQKRWQELADHP-LVGEARGVGMVGALEL 405 Query: 445 PDESIRNK---------LISIARNKGVMLGGCGDKSIRFRPTLVFRDHHAHLFLNIFSDI 495 + G+++ GD I P LV + + Sbjct: 406 VKNKKTRERFENGVGMLCREHCFRNGLIMRAVGDTMI-ISPPLVITKPEIDELITLARKC 464 Query: 496 LA 497 L Sbjct: 465 LD 466 >5KR5-A nrPDB Length = 479 Score = 372 bits (956), Expect = e-103, Method: Composition-based stats. Identities = 90/448 (20%), Positives = 160/448 (35%), Gaps = 59/448 (13%) Query: 80 SRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGILPPENF 139 +G + D +G +D ++ + + IGY + + + + + + Sbjct: 58 GKGIRIEDHEGREYIDAFAGLYCVNIGYGREEVADAIYEQAKQLAYYHT--YVGHSNDPV 115 Query: 140 VEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELETCMI 199 +E + AP GM ++ GS +NE K + WY + G+ K Sbjct: 116 IELSSRIIEDWAPAGMKKVFYGMSGSDANETQIKLV--WYYNNVLGRPNKKK-------- 165 Query: 200 NQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFV 259 I++ ++HG + + T + H+ FD PI P Sbjct: 166 ----------IIARERSYHGSGIVTGSLTGLPSFHQ----HFDLPIDRVKHTVCPHWYNA 211 Query: 260 KENQQEE---ARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDIS 316 E A C+EE+E LI R+ T+A I EP+ GG ++ ++ + Sbjct: 212 PPGMSEAQFVAYCVEELEKLIA--REGADTIAAFIAEPVMGTGGIVPPPQGYWEAIQAVL 269 Query: 317 RKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGFFHKEEF------ 370 RKH + DEV G G G EH+G+ D++T +K + + Sbjct: 270 RKHDILLIADEVVCGFGRLGSKTGSEHYGIK--PDLITVAKGLTSAYAPLSAVIVSEKVW 327 Query: 371 -------RPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDLQ 423 R + T+ G P ++I++RE+L NAA G L L + Sbjct: 328 DVIEKGSREHGVMGHGWTYSGHPVCAAAALANLDILERENLTGNAADVGAYLQQRLHEAF 387 Query: 424 ARYPQFISRVRGRGTFCSFDT-----------PDESIRNKLISIARNKGVMLGGC-GDKS 471 +P + VRG G + + P + K+ + A G+++ Sbjct: 388 GAHP-LVGEVRGVGMLAALEFMADKGARTPFDPALKVSQKVAAAALEDGLIVRALPHGDI 446 Query: 472 IRFRPTLVFRDHHAHLFLNIFSDILADF 499 + F P LV + I + + Sbjct: 447 LGFAPPLVTTRAEVDEIVAIAKEAFDEV 474 >5VIU-A nrPDB Length = 419 Score = 370 bits (951), Expect = e-103, Method: Composition-based stats. Identities = 87/437 (19%), Positives = 163/437 (37%), Gaps = 58/437 (13%) Query: 72 HFFCNYEESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPAL 131 + G ++ DV+G + D S S++ G+SHP +V+ + + + +R Sbjct: 32 PLPVVLDRGEGVFVWDVEGKKYYDFLSAYSAVNQGHSHPKIVEALVEQASKLALTSRAF- 90 Query: 132 GILPPENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSK 191 + + + + + S+ G +++ M G+ + E A K W + Sbjct: 91 ----YNSKLGEYEQKITSLL--GFDKVLPMNSGAEAVETAVKLARKWSYEVK-------- 136 Query: 192 EELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRL 251 I+ FHGRT ++ ++ ++ P F P Sbjct: 137 ----------GIAENAAKIIVCENNFHGRTTTIVSFSNDPDANQNYGP-FTPGFIRIPY- 184 Query: 252 KYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRK 311 ++ L K+ +A +VEPIQ E G ++ F ++ Sbjct: 185 -------------------NDIAALEEVLSKEAGNIAAFLVEPIQGEAGVYVPNEGFLKQ 225 Query: 312 LRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGFFHKEEFR 371 ++ +KH F+ DEVQTG TGK A H + D++ K + G + Sbjct: 226 SSELCKKHNVLFIADEVQTGIARTGKLIACHHEDVQ--PDILILGKALSGGMYPVSAVLA 283 Query: 372 PN------APYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDLQAR 425 N P + +T+ G+P + +++++ E L A G + + + L + Sbjct: 284 NNNIMDVIKPGQHGSTFGGNPLACAVAMAALDVVQDEKLSERAEKLGNLFRSEIEKLIEK 343 Query: 426 YPQFISRVRGRGTFCSF---DTPDESIRNKLISIARNKGVMLGGCGDKSIRFRPTLVFRD 482 I++VRG+G + DTPD S L + G++ IR P LV + Sbjct: 344 -TDLITKVRGKGLLNAILINDTPDSSTAWNLCLALKENGLLAKPTHGNIIRLAPPLVITE 402 Query: 483 HHAHLFLNIFSDILADF 499 + I + +F Sbjct: 403 EQLLDCVKIIEKTILEF 419 >3N5M-A nrPDB Length = 452 Score = 368 bits (944), Expect = e-102, Method: Composition-based stats. Identities = 94/446 (21%), Positives = 172/446 (38%), Gaps = 59/446 (13%) Query: 79 ESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGILPPEN 138 ++ G ++ D+ G R LD S + + GY L + + ++ + P Sbjct: 37 KAEGCWVEDIQGKRYLDGMSGLWCVNSGYGRKELAEAAYKQLQTLSYF-PMSQSHEPAIK 95 Query: 139 FVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELETCM 198 EKL E L G + GS +NE AFK +Y K Sbjct: 96 LAEKLNEWL-----GGEYVIFFSNSGSEANETAFKIARQYYAQKGEP------------- 137 Query: 199 INQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEF 258 Y +S +HG TM +A T P + P Y + Sbjct: 138 -------HRYKFMSRYRGYHGNTMATMAATGQAQRRYQYEPFASGFLHVTPPDCYRMPGI 190 Query: 259 VKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDISRK 318 +EN + C++EV+ ++ + +T+A I+EPI + GG A D+ + + + +K Sbjct: 191 ERENIYD-VECVKEVDRVMT--WELSETIAAFIMEPIITGGGILMAPQDYMKAVHETCQK 247 Query: 319 HGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGFFHK---------EE 369 HG + DEV G G TGK + ++ + D++T +K + + E Sbjct: 248 HGALLISDEVICGFGRTGKAFGFMNYDVK--PDIITMAKGITSAYLPLSATAVKREIYEA 305 Query: 370 FRPNAPYR---IFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDLQARY 426 F+ Y NT+ G+P+ L + + II+ E+L+ +A G +LL L + + Sbjct: 306 FKGKGEYEFFRHINTFGGNPAACALALKNLEIIENENLIERSAQMGSLLLEQLKEEIGEH 365 Query: 427 PQFISRVRGRGTFCSFDTPDESIRNK---------LISIARNKGVMLGGCG------DKS 471 P + +RG+G + ++ + +++ + KG+++G G + Sbjct: 366 P-LVGDIRGKGLLVGIELVNDKETKEPIDNDKIASVVNACKEKGLIIGRNGMTTAGYNNI 424 Query: 472 IRFRPTLVFRDHHAHLFLNIFSDILA 497 + P LV + + Sbjct: 425 LTLAPPLVISSEEIAFVIGTLKTAME 450 >3Q8N-A nrPDB Length = 453 Score = 365 bits (938), Expect = e-101, Method: Composition-based stats. Identities = 116/471 (24%), Positives = 191/471 (40%), Gaps = 55/471 (11%) Query: 46 MKTEVPGPRSRELM-KQLNIIQNAEAVHFFCNYEESRGNYLVDVDGNRMLDLYSQISSIP 104 + T +PGP S+EL ++ + + V + G L D DGN+++D S I+ Sbjct: 22 LVTAIPGPISQELQARKQSAVAAGVGVTLPVYVVAAGGGVLADADGNQLIDFGSGIAVTT 81 Query: 105 IGYSHPALVKLVQQPQNVSTFINRPALGILPPENFVEKLRESLLSVAPKGMS-QLITMAC 163 +G S PA+V V Q + P E +V K+ E L + P + Sbjct: 82 VGNSAPAVVDAVTQQ---VAAFTHTCFMVTPYEGYV-KVAEHLNRLTPGDHEKRTALFNS 137 Query: 164 GSCSNENAFKTIFMWYRSKERGQSAFSKEELETCMINQAPGCPDYSILSFMGAFHGRTMG 223 G+ + ENA K + R + ++ F A+HGRT Sbjct: 138 GAEAVENAVKIARAYTRRQA--------------------------VVVFDHAYHGRTNL 171 Query: 224 CLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKK 283 +A T +K F + P YP + + A L+ + + Sbjct: 172 TMAMTAKNQPYKHGFGPFANEVYRVP-TSYPFRDGETDGAAAAAHALDLINKQV-----G 225 Query: 284 KKTVAGIIVEPIQSEGGDNHASDDFFRKLRDISRKHGCAFLVDEVQTGGGSTGKFWAHEH 343 VA +++EP+ EGG + F L+ +G F+ DEVQTG TG +A EH Sbjct: 226 ADNVAAVVIEPVHGEGGFVVPAPGFLGALQKWCTDNGAVFVADEVQTGFARTGALFACEH 285 Query: 344 WGLDDPADVMTFSKKMMTGGFF-----HKEEFRPNAPYRIFNTWLGDPSKNLLLAEVINI 398 + D++ +K + G E + T+ G+P VI+ Sbjct: 286 ENV--VPDLIVTAKGIAGGLPLSAVTGRAEIMDGPQSGGLGGTYGGNPLACAAALAVIDT 343 Query: 399 IKREDLLSNAAHAGKVLLTGLLDLQARYPQFISRVRGRGTFCSFDT-------PDESIRN 451 I+RE+L++ A G+ +L+ L L A P+ I VRGRG + + PD + Sbjct: 344 IERENLVARARAIGETMLSRLGALAAADPR-IGEVRGRGAMIAVELVKPGTTEPDADLTK 402 Query: 452 KLISIARNKGVMLGGCG--DKSIRFRPTLVFRDHHAHLFLNIFSDILADFK 500 ++ + A +G+++ CG +RF P L DH L+I + + A+ K Sbjct: 403 RVAAAAHAQGLVVLTCGTYGNVLRFLPPLSMPDHLLDEGLDILAAVFAEVK 453 >2E54-A nrPDB Length = 385 Score = 365 bits (937), Expect = e-101, Method: Composition-based stats. Identities = 97/429 (22%), Positives = 159/429 (37%), Gaps = 59/429 (13%) Query: 72 HFFCNYEESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPAL 131 F + +G+++ D GN LD S I+ +G+SHP LV+ ++ + Sbjct: 9 RFPATFVYGKGSWIYDEKGNAYLDFTSGIAVNVLGHSHPRLVEAIKDQAEKLIHCSNLF- 67 Query: 132 GILPPENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSK 191 +L E L G ++ G+ +NE A K Sbjct: 68 ----WNRPQMELAELLSKNTFGG--KVFFANTGTEANEAAIKIAR--------------- 106 Query: 192 EELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRL 251 + Y ILS +FHGRT+G L T K P Sbjct: 107 ------KYGKKKSEKKYRILSAHNSFHGRTLGSLTATGQPKYQKPFEPLV---------- 150 Query: 252 KYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRK 311 P E+ + N E+ R RK + V + +EPIQ E G A+ +F + Sbjct: 151 --PGFEYFEFNNVEDLR------------RKMSEDVCAVFLEPIQGESGIVPATKEFLEE 196 Query: 312 LRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGFFHKEEFR 371 R + ++ + DEVQ G G TGK +A++ +G+ DV+T +K + G Sbjct: 197 ARKLCDEYDALLVFDEVQCGMGRTGKLFAYQKYGV--VPDVLTTAKGLGGGVPIGAVIVN 254 Query: 372 PNA----PYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDLQARYP 427 A P T+ G+P VI + +E L G L+ L +++ Y Sbjct: 255 ERANVLEPGDHGTTFGGNPLACRAGVTVIKELTKEGFLEEVEEKGNYLMKKLQEMKEEY- 313 Query: 428 QFISRVRGRGTFCSFDTPDESIRNKLISIARNKGVMLGGCGDKSIRFRPTLVFRDHHAHL 487 ++ VRG G +E ++ + +++ G+ +IRF P L L Sbjct: 314 DVVADVRGMGLMIGIQFREEVSNREVATKCFENKLLVVPAGNNTIRFLPPLTVEYGEIDL 373 Query: 488 FLNIFSDIL 496 + +L Sbjct: 374 AVETLKKVL 382 >1SFF-A nrPDB Length = 426 Score = 363 bits (931), Expect = e-100, Method: Composition-based stats. Identities = 107/459 (23%), Positives = 182/459 (39%), Gaps = 57/459 (12%) Query: 58 LMKQLNIIQNAEAVHFFCNYEESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQ 117 + ++ I + + + DV+G LD I+ + G+ HP +V V+ Sbjct: 8 MQRRSQAIPRGVGQIHPIFADRAENCRVWDVEGREYLDFAGGIAVLNTGHLHPKVVAAVE 67 Query: 118 QPQNVSTFINRPALGILPPENFVEKLRESLLSVAPKGM-SQLITMACGSCSNENAFKTIF 176 ++ +L E ++E L E + P + + + GS + ENA K Sbjct: 68 AQLKK---LSHTCFQVLAYEPYLE-LCEIMNQKVPGDFAKKTLLVTTGSEAVENAVKIAR 123 Query: 177 MWYRSKERGQSAFSKEELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKI 236 + ++F GA+HGRT LA T + Sbjct: 124 AATKRSGT--------------------------IAFSGAYHGRTHYTLALTGKVNPYSA 157 Query: 237 DIPSFDWPIAPFPRLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQ 296 + + PL +++ I K + +A I++EP+Q Sbjct: 158 GMGLMPGHVYRALYP-CPLHGISEDDAIASIH-------RIFKNDAAPEDIAAIVIEPVQ 209 Query: 297 SEGGDNHASDDFFRKLRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFS 356 EGG +S F ++LR + +HG + DEVQ+G G TG +A E G+ D+ TF+ Sbjct: 210 GEGGFYASSPAFMQRLRALCDEHGIMLIADEVQSGAGRTGTLFAMEQMGV--APDLTTFA 267 Query: 357 KKMMTGGFF-----HKEEFRPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHA 411 K + G E AP + T+ G+P + EV+ + ++E+LL A Sbjct: 268 KSIAGGFPLAGVTGRAEVMDAVAPGGLGGTYAGNPIACVAALEVLKVFEQENLLQKANDL 327 Query: 412 GKVLLTGLLDLQARYPQFISRVRGRGTFCSFDT--------PDESIRNKLISIARNKGVM 463 G+ L GLL + ++P+ I VRG G + + PD + ++++ AR+KG++ Sbjct: 328 GQKLKDGLLAIAEKHPE-IGDVRGLGAMIAIELFEDGDHNKPDAKLTAEIVARARDKGLI 386 Query: 464 LGGCGD--KSIRFRPTLVFRDHHAHLFLNIFSDILADFK 500 L CG +R L D L I S + K Sbjct: 387 LLSCGPYYNVLRILVPLTIEDAQIRQGLEIISQCFDEAK 425 >5GHG-A nrPDB Length = 456 Score = 362 bits (928), Expect = e-100, Method: Composition-based stats. Identities = 105/455 (23%), Positives = 180/455 (39%), Gaps = 62/455 (13%) Query: 74 FCNYEESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGI 133 E G Y+ DV G R ++ S + S+ +G+S P L + + F + + Sbjct: 31 PLVIERGDGIYVEDVSGKRYIEAMSGLLSVGVGFSEPRLAEAAARQMKKLPFYHTFSYRS 90 Query: 134 LPPENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEE 193 P V L E L+S+AP MS+ GS +N+ K I WYRS G+ K Sbjct: 91 HGP---VIDLAEKLVSMAPVPMSKAYFTNSGSEANDTVVKLI--WYRSNALGEPERKK-- 143 Query: 194 LETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKY 253 I+S +HG T+ + T H+ SFD PI Sbjct: 144 ----------------IISRKRGYHGVTIASASLTGLPNNHR----SFDLPIDRILHTGC 183 Query: 254 PLE----EFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFF 309 P + + +Q R +E+E LI+ + T+A I EP+ GG ++ Sbjct: 184 PHFYREGQAGESEEQFATRLADELEQLIIA--EGPHTIAAFIGEPVMGAGGVVVPPKTYW 241 Query: 310 RKLRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGG------ 363 K++ + +++ + DEV G G TG + + + + D++ SK++ + Sbjct: 242 EKVQAVLKRYDILLIADEVICGFGRTGNLFGSQTFDMK--PDILVMSKQLSSSYLPISAF 299 Query: 364 FFHKEEFRPNAPYRI-------FNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLL 416 ++ + P A T G P + E + II+ DL++NA G + Sbjct: 300 LINERVYAPIAEESHKIGTLGTGFTASGHPVAAAVALENLAIIEERDLVANARDRGTYMQ 359 Query: 417 TGLLDLQARYPQFISRVRGRGTFCSFDT-----------PDESIRNKLISIARNKGVMLG 465 L +LQ +P + VRG G + P ++ K ++ + +GV+ Sbjct: 360 KRLRELQ-DHP-LVGEVRGVGLIAGVELVTDKQAKTGLEPTGALGAKANAVLQERGVISR 417 Query: 466 GCGDKSIRFRPTLVFRDHHAHLFLNIFSDILADFK 500 GD ++ F P L+ D ++ L D + Sbjct: 418 AMGD-TLAFCPPLIINDQQVDTMVSALEATLNDVQ 451 >6G4F-A nrPDB Length = 464 Score = 362 bits (928), Expect = e-100, Method: Composition-based stats. Identities = 94/453 (20%), Positives = 175/453 (38%), Gaps = 62/453 (13%) Query: 74 FCNYEESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGI 133 E G Y+ D G ++ + + S +G+S+ L+K +Q N F + + Sbjct: 31 PLIIERGEGIYVYDDQGKGYIEAMAGLWSAALGFSNQRLIKAAEQQFNTLPFYHLFSHKS 90 Query: 134 LPPENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEE 193 P +L E L+ +AP MS++ GS +N+ K + WY + G+ A K Sbjct: 91 HRPS---IELAEKLIEMAPVPMSKVFFTNSGSEANDTVVKMV--WYLNNALGKPAKKK-- 143 Query: 194 LETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKY 253 +S + +HG T+ + T + FD P+ F + Sbjct: 144 ----------------FISRVNGYHGITVASASLTGLPGNQR----GFDLPLPGFLHVGC 183 Query: 254 PLEE----FVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFF 309 P + + R E+E I+ + +T+A I EP+ GG ++ Sbjct: 184 PHHYRFALAGESEEHFADRLAVELEQKILA--EGPETIAAFIGEPLMGAGGVIVPPRTYW 241 Query: 310 RKLRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGFFHKEE 369 K++ + RK+ + DEV G G TG+ + + +G+ D+M SK++ + Sbjct: 242 EKIQKVCRKYDILVIADEVICGFGRTGQMFGSQTFGIQ--PDIMVLSKQLSSSYQPIAAI 299 Query: 370 F-------------RPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLL 416 + T G P + E + II+ E L+ +AA G++L Sbjct: 300 LINAPVFEGIADQSQALGALGHGFTGSGHPVATAVALENLKIIEEESLVEHAAQMGQLLR 359 Query: 417 TGLLDLQARYPQFISRVRGRGTFCSFDTPDESIRN-----------KLISIARNKGVMLG 465 +GL +P + +RG G + + + + + A+ G++ Sbjct: 360 SGLQHFI-DHP-LVGEIRGCGLIAAVELVGDRVSKAPYQALGTLGRYMAGRAQEHGMITR 417 Query: 466 GCGDKSIRFRPTLVFRDHHAHLFLNIFSDILAD 498 GD ++ F P L+ + + + F+ L D Sbjct: 418 AMGD-AVAFCPPLIVNEQEVGMIVERFARALDD 449 >5KQU-A nrPDB Length = 479 Score = 360 bits (924), Expect = e-100, Method: Composition-based stats. Identities = 82/448 (18%), Positives = 152/448 (33%), Gaps = 59/448 (13%) Query: 80 SRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGILPPENF 139 + G + D +G ++D ++ + + IGY + + + + + E Sbjct: 58 ASGIRIRDHEGRELIDAFAGLYCVNIGYGRTEVADAIYKQAKELAYYHT--YVGHSTEAI 115 Query: 140 VEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELETCMI 199 +E + AP GM ++ GS +NE K + + R Q Sbjct: 116 IELSSRIIRDWAPAGMKKVYYGLSGSDANETQIKLVRYYNNVLGRPQK------------ 163 Query: 200 NQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFV 259 I+S +HG + + T + H+ FD P+ P Sbjct: 164 --------KKIISRQRGYHGSGIMTGSLTGLPSFHQ----HFDLPVEGIKHTVCPHWYKA 211 Query: 260 KENQQEEA---RCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDIS 316 E A C +E+E LI+ + TVA I EP+ GG ++ ++ + Sbjct: 212 PAGMDEAAFVRYCADELEKLILA--EGPDTVAAFIGEPVMGTGGIIVPPKGYWEAIQAVL 269 Query: 317 RKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGFFHKEEFRPNAPY 376 K+ + DEV G G + +G+ D++T +K + + + Sbjct: 270 NKYDVLLIADEVVCAFGRLGSKMGSQRYGMR--PDLITTAKGLTSAYAPLSAVIVGEKVW 327 Query: 377 -------------RIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDLQ 423 T+ G P ++I++RE+L +NAA G L L + Sbjct: 328 DVIEKASQKEGAMGHGWTYSGHPICAAAALANLDILERENLTANAADVGAYLNQRLRETF 387 Query: 424 ARYPQFISRVRGRGTFCSFDT-----------PDESIRNKLISIARNKGVMLGGC-GDKS 471 +P + VRG G + + P + K+ + G++ Sbjct: 388 EGHP-LVGEVRGDGMLAALEFMADREARTPFDPALKVGPKVSAACLEDGMIARAMPHGDI 446 Query: 472 IRFRPTLVFRDHHAHLFLNIFSDILADF 499 + F P LV A + I + + Sbjct: 447 LGFAPPLVLTRAEADEIVGIAKAAVDEV 474 >6GWI-A nrPDB Length = 462 Score = 359 bits (921), Expect = 2e-99, Method: Composition-based stats. Identities = 82/456 (17%), Positives = 165/456 (36%), Gaps = 59/456 (12%) Query: 68 AEAVHFFCNYEESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFIN 127 A + G Y+ D +GNR+LD + + + +GY LV+ + N Sbjct: 24 ALGEEGSRVVTHAEGVYIHDSEGNRILDGMAGLWCVNLGYGRRELVEAATAQLEQLPYYN 83 Query: 128 RPALGILPPENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQS 187 PP +L E L +AP ++++ GS +N+ + + ++ K + Sbjct: 84 TFFKTTHPP---AVRLAEKLCDLAPAHINRVFFTGSGSEANDTVLRMVRRYWALKGQPDK 140 Query: 188 AFSKEELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAP 247 + I+ A+HG T+ ++ +H P + Sbjct: 141 QW--------------------IIGRENAYHGSTLAGMSLGGMAPMHAQGGPC----VPG 176 Query: 248 FPRLKYPLEEFVKENQQEEA---RCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHA 304 ++ P + EA C E +E+ I++ + + VA I EP+Q GG Sbjct: 177 IAHIRQPYWFGEGRDMSPEAFGQTCAEALEEKILELGE--EKVAAFIAEPVQGAGGAIMP 234 Query: 305 SDDFFRKLRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMT--- 361 + ++ ++ + K+ + DEV G G G+++ +H+GL+ D+M +K + + Sbjct: 235 PESYWPAVKKVLAKYDILLVADEVICGFGRLGEWFGSQHYGLE--PDLMPIAKGLSSGYL 292 Query: 362 --GGFFHKEEFR-----PNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAA-HAGK 413 GG + + T+ G P+ + + + +++ E ++ G Sbjct: 293 PIGGVLVGDRVAETLIEEGGEFFHGFTYSGHPTCAAVALKNLELLEAEGVVDRVRDDLGP 352 Query: 414 VLLTGLLDLQARYPQFISRVRGRGTFCSFDTPDESIR-----------NKLISIARNKGV 462 L L +P + R G + + + N + G+ Sbjct: 353 YLAERWASLV-DHP-IVGEARSLGLMGALELVADKTTGQRFDKSLGAGNLCRDLCFANGL 410 Query: 463 MLGGCGDKSIRFRPTLVFRDHHAHLFLNIFSDILAD 498 ++ GD I P LV R + + L + Sbjct: 411 VMRSVGDTMI-ISPPLVIRREEIDELVELARRALDE 445 >2EH6-A nrPDB Length = 375 Score = 355 bits (910), Expect = 4e-98, Method: Composition-based stats. Identities = 103/431 (23%), Positives = 172/431 (39%), Gaps = 68/431 (15%) Query: 71 VHFFCNYEESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPA 130 + +G YL D +G LD S I +G+++P L + +++ ++ Sbjct: 8 ARLPVKFVRGKGVYLYDEEGKEYLDFVSGIGVNSLGHAYPKLTEALKEQVEK--LLHVSN 65 Query: 131 LGILPPENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFS 190 L P + E+L L+ ++ G+ S E A K ++R K Sbjct: 66 LYENPWQ---EELAHKLVKHF-WTEGKVFFANSGTESVEAAIKLARKYWRDK-------- 113 Query: 191 KEELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPR 250 G + +SF +FHGRT G L+ T HK P Sbjct: 114 -------------GKNKWKFISFENSFHGRTYGSLSATGQPKFHKGFEPLVPGFSY---- 156 Query: 251 LKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFR 310 ++ D+ Y+ + AGII+E IQ EGG N AS+DF Sbjct: 157 --------------------AKLNDIDSVYKLLDEETAGIIIEVIQGEGGVNEASEDFLS 196 Query: 311 KLRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGFFHK--- 367 KL++I ++ ++DEVQTG G TG+F+A++H+ L DV+ +K + G Sbjct: 197 KLQEICKEKDVLLIIDEVQTGIGRTGEFYAYQHFNLK--PDVIALAKGLGGGVPIGAILA 254 Query: 368 --EEFRPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDLQAR 425 E + P +T+ G+P V++ + E LL + G L +L Sbjct: 255 REEVAQSFTPGSHGSTFGGNPLACRAGTVVVD--EVEKLLPHVREVGNYFKEKLKELGK- 311 Query: 426 YPQFISRVRGRGTFCSFDTPDESIRNKLISIARNKGVMLGGCGDKSIRFRPTLVFRDHHA 485 +V+GRG + E + A KG+++ K +RF P L+ + H Sbjct: 312 -----GKVKGRGLMLGLELEREC--KDYVLKALEKGLLINCTAGKVLRFLPPLIIQKEHI 364 Query: 486 HLFLNIFSDIL 496 +++ +IL Sbjct: 365 DRAISVLREIL 375 >2EO5-A nrPDB Length = 419 Score = 354 bits (909), Expect = 4e-98, Method: Composition-based stats. Identities = 113/438 (25%), Positives = 186/438 (42%), Gaps = 52/438 (11%) Query: 73 FFCNYEESRGNYLVDVDGNRMLDLYSQISSIPIGY-SHPALVKLVQQPQNVSTFINRPAL 131 F + G ++ DVDGN+ LD S I +G+ SHP ++K+ + Sbjct: 24 FPLVIDHGEGVWIYDVDGNKYLDFTSGIGVNNLGWPSHPEVIKIGIEQMQKLAHAAANDF 83 Query: 132 GILPPENFVEKLRESLLSVAPKGM-SQLITMACGSCSNENAFKTIFMWYRSKERGQSAFS 190 +P L + L++ +P ++ G+ + E + K + Sbjct: 84 YNIPQLE----LAKKLVTYSPGNFQKKVFFSNSGTEAIEASIKVV--------------- 124 Query: 191 KEELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPI--APF 248 I++F+G FHGRT G ++ T SKA+ + + F + P+ Sbjct: 125 ------------KNTGRKYIIAFLGGFHGRTFGSISLTASKAVQRSIVGPFMPGVIHVPY 172 Query: 249 PRLKY-PLEEFVKENQQEEA-RCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASD 306 P P EN E R +E +ED I + VAGI EPIQ EGG Sbjct: 173 PNPYRNPWHINGYENPSELVNRVIEFIEDYIFVNLVPPEEVAGIFFEPIQGEGGYVIPPK 232 Query: 307 DFFRKLRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGFFH 366 +FF +L+ +++K+G + DEVQ G G TGK +A E++ DV+T +K + G Sbjct: 233 NFFAELQKLAKKYGILLVDDEVQMGLGRTGKLFAIENFN--TVPDVITLAKALGGGIMPI 290 Query: 367 KEEF----RPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDL 422 P NT+ G+ + ++VI+I+K DLL + GK+ L L Sbjct: 291 GATIFRKDLDFKPGMHSNTFGGNALACAIGSKVIDIVK--DLLPHVNEIGKIFAEELQGL 348 Query: 423 QARYPQFISRVRGRGTFCSFDTPDESIRNKLISIARNKGVMLGGCGDKSIRFRPTLVFRD 482 VRG G + ++ +R+++I + +G++L G +IR P LV + Sbjct: 349 AD-------DVRGIGLAWGLEYNEKKVRDRIIGESFKRGLLLLPAGRSAIRVIPPLVISE 401 Query: 483 HHAHLFLNIFSDILADFK 500 A L+I ++ K Sbjct: 402 EEAKQGLDILKKVIKVVK 419 >1OAT-A nrPDB Length = 439 Score = 354 bits (909), Expect = 4e-98, Method: Composition-based stats. Identities = 90/456 (19%), Positives = 169/456 (37%), Gaps = 63/456 (13%) Query: 53 PRSRELMKQLNIIQNAEAVHFFCNYEESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPAL 112 P S ++ ++ E +G YL DV+G + D S S++ G+ HP + Sbjct: 38 PTSDDIFEREYKYGAHNYHPLPVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKI 97 Query: 113 VKLVQQPQNVSTFINRPALGILPPENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAF 172 V ++ + T +R N + + E + + +++ M G + E A Sbjct: 98 VNALKSQVDKLTLTSRAF-----YNNVLGEYEEYITKLF--NYHKVLPMNTGVEAGETAC 150 Query: 173 KTIFMWYRSKERGQSAFSKEELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKA 232 K W + + Q +K I+ G F GRT+ ++++ Sbjct: 151 KLARKWGYTVKGIQKYKAK------------------IVFAAGNFWGRTLSAISSSTDPT 192 Query: 233 IHKIDIPSFDWPIAPFPRLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIV 292 + P F+ L +E + VA +V Sbjct: 193 SYDGFGP------------------FMPGFDIIPYNDLPALERALQ-----DPNVAAFMV 229 Query: 293 EPIQSEGGDNHASDDFFRKLRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADV 352 EPIQ E G + +R++ +H F+ DE+QTG TG++ A ++ + D+ Sbjct: 230 EPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVR--PDI 287 Query: 353 MTFSKKMMTGGFFHK------EEFRPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLS 406 + K + G + + P +T+ G+P + + +++ E+L Sbjct: 288 VLLGKALSGGLYPVSAVLCDDDIMLTIKPGEHGSTYGGNPLGCRVAIAALEVLEEENLAE 347 Query: 407 NAAHAGKVLLTGLLDLQARYPQFISRVRGRGTFCSF---DTPDESIRNKLISIARNKGVM 463 NA G +L L+ L ++ VRG+G + +T D K+ R+ G++ Sbjct: 348 NADKLGIILRNELMKLP---SDVVTAVRGKGLLNAIVIKETKDWD-AWKVCLRLRDNGLL 403 Query: 464 LGGCGDKSIRFRPTLVFRDHHAHLFLNIFSDILADF 499 IRF P LV ++ + I + + F Sbjct: 404 AKPTHGDIIRFAPPLVIKEDELRESIEIINKTILSF 439 >1Z7D-A nrPDB Length = 433 Score = 354 bits (908), Expect = 5e-98, Method: Composition-based stats. Identities = 98/435 (22%), Positives = 166/435 (38%), Gaps = 58/435 (13%) Query: 72 HFFCNYEESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPAL 131 + ++G ++ DV+ R D S SS+ G+ HP ++ + T +R Sbjct: 46 PIPVVLKRAKGVFVYDVNDKRYYDFLSAYSSVNQGHCHPNILNAMINQAKNLTICSRAFF 105 Query: 132 GILPPENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSK 191 + P E+ +LL G +++ M G+ +NE A+K W ++ +K Sbjct: 106 SV--PLGICERYLTNLL-----GYDKVLMMNTGAEANETAYKLCRKWGYEVKKIPENMAK 158 Query: 192 EELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRL 251 I+ F GRT+GC++ + +K P Sbjct: 159 ------------------IVVCKNNFSGRTLGCISASTTKKCTSNFGP------------ 188 Query: 252 KYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRK 311 F + + LE +E+ K V IVEPIQ E G SD++ + Sbjct: 189 ------FAPQFSKVPYDDLEALEE-----ELKDPNVCAFIVEPIQGEAGVIVPSDNYLQG 237 Query: 312 LRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGFFHKEEFR 371 + DI +K+ F+ DEVQTG G TGK H+ + DV+ K + G + Sbjct: 238 VYDICKKYNVLFVADEVQTGLGRTGKLLCVHHYNVK--PDVILLGKALSGGHYPISAVLA 295 Query: 372 PN------APYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDLQAR 425 + P +T+ G+P + E +N++ E L NA G L L + Sbjct: 296 NDDIMLVIKPGEHGSTYGGNPLAASICVEALNVLINEKLCENAEKLGGPFLENLKREL-K 354 Query: 426 YPQFISRVRGRGTFCSFDTPDESIRN-KLISIARNKGVMLGGCGDKSIRFRPTLVFRDHH 484 + + VRG+G C+ + +E + + + G++ DK+IR P L Sbjct: 355 DSKIVRDVRGKGLLCAIEFKNELVNVLDICLKLKENGLITRDVHDKTIRLTPPLCITKEQ 414 Query: 485 AHLFLNIFSDILADF 499 I + F Sbjct: 415 LDECTEIIVKTVKFF 429 >3NTJ-A nrPDB Length = 422 Score = 352 bits (904), Expect = 1e-97, Method: Composition-based stats. Identities = 91/435 (20%), Positives = 161/435 (37%), Gaps = 58/435 (13%) Query: 72 HFFCNYEESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPAL 131 + +G ++ D++ R D S SS+ G+ HP ++ + T +R Sbjct: 27 PIPVVLKRGKGVFVYDIEDRRYYDFLSAYSSVNQGHCHPDILNAMINQAKKLTICSRAFF 86 Query: 132 GILPPENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSK 191 E+ +L G +++ M G+ ++E A+K W ++ +K Sbjct: 87 SDS--LGVCERYLTNLF-----GYDKVLMMNTGAEASETAYKLCRKWGYEVKKIPENSAK 139 Query: 192 EELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRL 251 I+ F GRT+GC++ + K P Sbjct: 140 ------------------IIVCNNNFSGRTLGCVSASTDKKCKNNFGP------------ 169 Query: 252 KYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRK 311 FV + LE +E + V IVEP+Q E G SD +F Sbjct: 170 ------FVPNFLKVPYDDLEALEKELQ-----DPNVCAFIVEPVQGEAGVIVPSDSYFPG 218 Query: 312 LRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGFF------ 365 + + +K+ F+ DEVQTG G TGK H+G+ DV+ K + G + Sbjct: 219 VASLCKKYNVLFVADEVQTGLGRTGKLLCTHHYGVK--PDVILLGKALSGGHYPISAILA 276 Query: 366 HKEEFRPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDLQAR 425 + + P +T+ G+P + E + ++ E L NA G L L + Q + Sbjct: 277 NDDVMLVLKPGEHGSTYGGNPLAAAICVEALKVLINEKLCENADKLGAPFLQNLKE-QLK 335 Query: 426 YPQFISRVRGRGTFCSFDTPDESIR-NKLISIARNKGVMLGGCGDKSIRFRPTLVFRDHH 484 + + VRG+G C+ + ++ + + + G++ DK++R P L Sbjct: 336 DSKVVREVRGKGLLCAIEFKNDLVNVWDICLKFKENGLITRSVHDKTVRLTPPLCITKEQ 395 Query: 485 AHLFLNIFSDILADF 499 I + F Sbjct: 396 LDECTEIIVKTVKFF 410 >6FYQ-A nrPDB Length = 484 Score = 352 bits (902), Expect = 2e-97, Method: Composition-based stats. Identities = 92/451 (20%), Positives = 167/451 (37%), Gaps = 64/451 (14%) Query: 75 CNYEESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGIL 134 +E G YL DV G +D S + ++ +G+ L + Q F + + Sbjct: 65 VIMKEGDGIYLTDVTGKTYIDGVSSLWNVNVGHGRVELAEAAAQQMKKMAFSSAFSTFSH 124 Query: 135 PPENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEEL 194 P +L E + S+ P+G++ + + GS SN++A K + +++ + + Sbjct: 125 EP---AIRLAEKIASITPEGLNAVFFTSGGSESNDSAVKLVRHYWKIQGKPNKR------ 175 Query: 195 ETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYP 254 I+S ++HG + T + F + Sbjct: 176 --------------KIISLKRSYHGVAAASTSVTGIPEFW----GMAGHMMTDFLHVDTH 217 Query: 255 LEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRD 314 ++ Q + +EE +T+A EP+Q GG +D+F ++R+ Sbjct: 218 YNNTTEQAVQSLCQAIEE---------AGPETIAAFFAEPVQGAGGVIIPPEDYFLRIRE 268 Query: 315 ISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGFFHKEEFRPNA 374 + +G F+ DEV TG G TGK + E+W + DVMTF+K + +G F + Sbjct: 269 VCNAYGILFVADEVITGFGRTGKMFGIENWDV--IPDVMTFAKGVTSGYFPLGGVVVSDP 326 Query: 375 PYR-----------IFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDLQ 423 + T+ G P+ + + I IIK E L+ N+ G LL GL ++ Sbjct: 327 IHEVLKEKSVGTLFHGFTYSGHPTAAAVALKNIAIIKEERLVENSKRMGDALLHGLKKVK 386 Query: 424 ARYPQFISRVRGRGTFCSFDTPDESIRN-----------KLISIARNKGVMLGGC---GD 469 R + + VR G + + N K+I GV+ Sbjct: 387 NRL-EIVGDVRFVGLLGAVELMQNPATNKPFSSNLQVAPKVIEALHELGVICRSVTYDHT 445 Query: 470 KSIRFRPTLVFRDHHAHLFLNIFSDILADFK 500 I P L+ + + + + + Sbjct: 446 NIICLAPPLIINQKQVDKLVEVIYEAILKVQ 476 >5LL2-A nrPDB Length = 480 Score = 349 bits (894), Expect = 2e-96, Method: Composition-based stats. Identities = 101/441 (22%), Positives = 170/441 (38%), Gaps = 49/441 (11%) Query: 75 CNYEESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGIL 134 + + G LVDVDGN+ +DL + S+I +G++H +VK + + Sbjct: 59 LVIDHAHGATLVDVDGNKYIDLLASASAINVGHTHEKVVKAIADQAQKLIHYTPAYFHHV 118 Query: 135 PPENFVEKLRESLLSVAPKGMSQLI-TMACGSCSNENAFKTIFMWYRSKERGQSAFSKEE 193 P L E L +AP +++ GS +N+ K + + Sbjct: 119 PGME----LSEKLAKIAPGNSPKMVSFGNSGSDANDAIIKFARAYTGRQ----------- 163 Query: 194 LETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKY 253 I+S+MG++HG T G + S I + P Sbjct: 164 ---------------YIVSYMGSYHGSTYGSQTLSGSSLNMTRKIGPMLPSVVHVPYPDS 208 Query: 254 PLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLR 313 + R E + + +T A +++EPIQ +GG A +++ + + Sbjct: 209 YRTYPGETEHDVSLRYFNEFKKPFESFLPADET-ACVLIEPIQGDGGIIKAPEEYMQLVY 267 Query: 314 DISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTG----GFFHKEE 369 +HG F +DEV G G TGK WA + + D D+M+ K + +G K+E Sbjct: 268 KFCHEHGILFAIDEVNQGLGRTGKMWAIQQFK-DIEPDLMSVGKSLASGMPLSAVIGKKE 326 Query: 370 FRP--NAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDLQARYP 427 +AP +F T G+P + +++I+ E L+ +A G L++Q R+P Sbjct: 327 VMQSLDAPAHLFTT-AGNPVCSAASLATLDVIEYEGLVEKSATDGAYAKQRFLEMQQRHP 385 Query: 428 QFISRVRGRGTFCSFDT--------PDESIRNKLISIARNKGVMLGGCGDKSIRFRPTLV 479 I VR G + PD K+I A GV++ +RF+P LV Sbjct: 386 -MIGDVRMWGLNGGIELVKDPKTKEPDSDAATKVIYYAFAHGVVIITLAGNILRFQPPLV 444 Query: 480 FRDHHAHLFLNIFSDILADFK 500 L + D + Sbjct: 445 IPREQLDQALQVLDDAFTAVE 465 >3HMU-A nrPDB Length = 472 Score = 348 bits (893), Expect = 3e-96, Method: Composition-based stats. Identities = 85/458 (18%), Positives = 160/458 (34%), Gaps = 53/458 (11%) Query: 64 IIQNAEAVHFFCNYEESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVS 123 NA +RG +L D +G +LD + + + IGY L ++ + Sbjct: 28 SANNALGEEGTRVITRARGVWLNDSEGEEILDAMAGLWCVNIGYGRDELAEVAARQMREL 87 Query: 124 TFINRPALGILPPENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKE 183 + N P L + L +AP ++ + GS +N+ + + ++++K Sbjct: 88 PYYNTFFKTTHVP---AIALAQKLAELAPGDLNHVFFAGGGSEANDTNIRMVRTYWQNKG 144 Query: 184 RGQSAFSKEELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDW 243 + + I+S A+HG T+ A +H Sbjct: 145 QPEKTV--------------------IISRKNAYHGSTVASSALGGMAGMHAQ-----SG 179 Query: 244 PIAPFPRLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKT-VAGIIVEPIQSEGGDN 302 I + P + E L +L + + VA I EP+Q GG Sbjct: 180 LIPDVHHINQPNWWAEGGDMDPEEFGLARARELEEAILELGENRVAAFIAEPVQGAGGVI 239 Query: 303 HASDDFFRKLRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMT- 361 A D ++ +++ I K+ + DEV G G TG ++ + G+ +MT +K + + Sbjct: 240 VAPDSYWPEIQRICDKYDILLIADEVICGFGRTGNWFGTQTMGIR--PHIMTIAKGLSSG 297 Query: 362 ----GGFFHKEEFRP---NAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKV 414 GG +E + T+ G P + E + I++ E++L + + Sbjct: 298 YAPIGGSIVCDEVAHVIGKDEFNHGYTYSGHPVAAAVALENLRILEEENILDHVRNVAAP 357 Query: 415 LLTGLLDLQARYPQFISRVRGRGTFCSFD-TPDESIRNKLISI-----------ARNKGV 462 L + +P + + G S TP+++ R K S + Sbjct: 358 YLKEKWEALTDHP-LVGEAKIVGMMASIALTPNKASRAKFASEPGTIGYICRERCFANNL 416 Query: 463 MLGGCGDKSIRFRPTLVFRDHHAHLFLNIFSDILADFK 500 ++ GD+ I P LV L + + Sbjct: 417 IMRHVGDRMI-ISPPLVITPAEIDEMFVRIRKSLDEAQ 453 >5X3F-A nrPDB Length = 501 Score = 348 bits (892), Expect = 4e-96, Method: Composition-based stats. Identities = 94/445 (21%), Positives = 162/445 (36%), Gaps = 58/445 (13%) Query: 66 QNAEAVHFFCNYEESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTF 125 A + ++ N LVD G +D +G+ +P +V VQ Sbjct: 55 VTAGGDYGAVEWQAGSLNTLVDTQGQEFIDCLGGFGIFNVGHRNPVVVSAVQNQLAKQPL 114 Query: 126 INRPALGILPPENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERG 185 ++ L + L ++L ++ P + G+ S E A K + + + Sbjct: 115 HSQELL-----DPLRAMLAKTLAALTPGKLKYSFFCNSGTESVEAALKLAKAYQSPRGK- 168 Query: 186 QSAFSKEELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPI 245 ++ ++ GAFHG+++G L+ T K +P Sbjct: 169 ----------------------FTFIATSGAFHGKSLGALSATAKSTFRKPFMPLL---- 202 Query: 246 APFPRLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHAS 305 P V +E + + + +K VA +I+EPIQ EGG Sbjct: 203 --------PGFRHVPFGN------IEAMRTALNECKKTGDDVAAVILEPIQGEGGVILPP 248 Query: 306 DDFFRKLRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGFF 365 + +R + + G ++DEVQTG G TGK +A EH + D++ +K + G Sbjct: 249 PGYLTAVRKLCDEFGALMILDEVQTGMGRTGKMFACEHENVQ--PDILCLAKALGGGVMP 306 Query: 366 HKEEFRP--------NAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLT 417 + P+ T+ G+P IN++ ++L + A G +LL Sbjct: 307 IGATIATEEVFSVLFDNPFLHTTTFGGNPLACAAALATINVLLEQNLPAQAEQKGDMLLD 366 Query: 418 GLLDLQARYPQFISRVRGRGTFCSFDTPDESIRNKLISIARNKGVMLGGC--GDKSIRFR 475 G L YP + RG+G + + D I S + V++ G K+IR Sbjct: 367 GFRQLAREYPDLVQEARGKGMLMAIEFVDNEIGYNFASEMFRQRVLVAGTLNNAKTIRIE 426 Query: 476 PTLVFRDHHAHLFLNIFSDILADFK 500 P L L + LA + Sbjct: 427 PPLTLTIEQCELVIKAARKALAAMR 451 >4BA4-A nrPDB Length = 459 Score = 343 bits (879), Expect = 1e-94, Method: Composition-based stats. Identities = 80/447 (17%), Positives = 158/447 (35%), Gaps = 53/447 (11%) Query: 76 NYEESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGILP 135 G YL D +GN+++D + + + +GY + ++ F N P Sbjct: 35 VMTRGEGVYLWDSEGNKIIDGMAGLWCVNVGYGRKDFAEAARRQMEELPFYNTFFKTTHP 94 Query: 136 PENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELE 195 V +L L V P G ++ GS S + + + ++ + + + Sbjct: 95 A---VVELSSLLAEVTPAGFDRVFYTNSGSESVDTMIRMVRRYWDVQGKPEK-------- 143 Query: 196 TCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPL 255 +++ +HG T+G + K +H+ D PI ++ P Sbjct: 144 ------------KTLIGRWNGYHGSTIGGASLGGMKYMHEQG----DLPIPGMAHIEQPW 187 Query: 256 EEFVKENQQEEARCLEEVEDLIVKYRK-KKKTVAGIIVEPIQSEGGDNHASDDFFRKLRD 314 ++ + + L K + VA + EPIQ GG ++ ++ Sbjct: 188 WYKHGKDMTPDEFGVVAARWLEEKILEIGADKVAAFVGEPIQGAGGVIVPPATYWPEIER 247 Query: 315 ISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGFFHKEEFRPNA 374 I RK+ + DEV G G TG+++ H+H+G D+ T +K + +G F Sbjct: 248 ICRKYDVLLVADEVICGFGRTGEWFGHQHFGFQ--PDLFTAAKGLSSGYLPIGAVFVGKR 305 Query: 375 PYR---------IFNTWLGDPSKNLLLAEVINIIKREDLLSNA-AHAGKVLLTGLLDLQA 424 T+ G P + + ++ E ++ G + + + Sbjct: 306 VAEGLIAGGDFNHGFTYSGHPVCAAVAHANVAALRDEGIVQRVKDDIGPYMQKRWRETFS 365 Query: 425 RYPQFISRVRGRGTFCSFDTPDESIRN-------KLISIAR----NKGVMLGGCGDKSIR 473 R+ + VRG G +F + ++ ++ R +++ CGD + Sbjct: 366 RFEH-VDDVRGVGMVQAFTLVKNKAKRELFPDFGEIGTLCRDIFFRNNLIMRACGDHIVS 424 Query: 474 FRPTLVFRDHHAHLFLNIFSDILADFK 500 P LV L + L +F+ Sbjct: 425 -APPLVMTRAEVDEMLAVAERCLEEFE 450 >5KQT-A nrPDB Length = 479 Score = 341 bits (874), Expect = 4e-94, Method: Composition-based stats. Identities = 80/440 (18%), Positives = 148/440 (33%), Gaps = 59/440 (13%) Query: 80 SRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGILPPENF 139 + G + D G +LD ++ + + IGY + + + + + E Sbjct: 58 ASGVRIRDHQGRELLDAFAGLYCVNIGYGRLEVADAIHEQAKQLAYYHT--YVGHASEAI 115 Query: 140 VEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELETCMI 199 +E + AP GM ++ GS +NE K + + R Q Sbjct: 116 IELSARIIRDWAPAGMKKVYYGLSGSDANETQVKLVRYYNNVLGRPQK------------ 163 Query: 200 NQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFV 259 I+S +HG + + T + H+ FD P+ P Sbjct: 164 --------KKIISRQRGYHGSGIVTGSLTGLASFHQ----HFDLPVEGVKHTLCPHFYKA 211 Query: 260 KENQQEEA---RCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDIS 316 E A C +E+E+LI+ + TVA I EP+ GG ++ ++ + Sbjct: 212 PAGMDEAAFVRHCAQELENLILA--EGPDTVAAFIGEPVMGTGGIIVPPKGYWEAIQAVL 269 Query: 317 RKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGFFHKEEFRPNAPY 376 K+ + DEV G G + + D++T +K + + + Sbjct: 270 AKYDVLLIADEVVCAFGRLGDKMGSQRHAMR--PDLITTAKGLTSAYAPLSAVIVGEKVW 327 Query: 377 -------------RIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDLQ 423 T+ G P ++I++RE++ +NAA G L L Sbjct: 328 DVIDSASTREGAMGHGWTYSGHPICAAAALANLDILERENITANAADVGGYLNQQLRQAF 387 Query: 424 ARYPQFISRVRGRGTFCSFDTPDE-----------SIRNKLISIARNKGVMLGGC-GDKS 471 +P + VRG G + + + + K+ + +G++ Sbjct: 388 EGHP-LVGEVRGDGMLAALEFMADREARTPFDAALKVGPKVSAACLERGMIARAMPHGDI 446 Query: 472 IRFRPTLVFRDHHAHLFLNI 491 + F P LV A + I Sbjct: 447 LGFAPPLVLSRAEADEVVGI 466 >3GJU-A nrPDB Length = 460 Score = 340 bits (871), Expect = 1e-93, Method: Composition-based stats. Identities = 83/449 (18%), Positives = 159/449 (35%), Gaps = 61/449 (13%) Query: 80 SRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGILPPENF 139 G + D +G + +D ++ + + +GY + + + + + Sbjct: 40 GEGVTVWDNNGRKSIDAFAGLYCVNVGYGRQKIADAIATQAKNLAYYHA---YVGHGTEA 96 Query: 140 VEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELETCMI 199 L + ++ APKGMS++ GS +NE K I WY + G+ K Sbjct: 97 SITLAKMIIDRAPKGMSRVYFGLSGSDANETNIKLI--WYYNNVLGRPEKKK-------- 146 Query: 200 NQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPL---- 255 I+S +HG + + T H FD P AP + P Sbjct: 147 ----------IISRWRGYHGSGVMTGSLTGLDLFHNA----FDLPRAPVLHTEAPYYFRR 192 Query: 256 EEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDI 315 + +Q C +++E++I+ + +T+A I EPI GG ++ K++ + Sbjct: 193 TDRSMSEEQFSQHCADKLEEMILA--EGPETIAAFIGEPILGTGGIVPPPAGYWEKIQAV 250 Query: 316 SRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTG-----GFFHKEEF 370 +K+ + DEV TG G G + +H+G+ D++T +K + + G + Sbjct: 251 LKKYDVLLVADEVVTGFGRLGTMFGSDHYGIK--PDLITIAKGLTSAYAPLSGVIVADRV 308 Query: 371 --------RPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDL 422 T+ P + +I DL++NA G L Sbjct: 309 WQVLVQGSDKLGSLGHGWTYSAHPICVAAGVANLELIDEMDLVTNAGETGAYFRAELAKA 368 Query: 423 QARYPQFISRVRGRGTFCSFDTPDE-----------SIRNKLISIARNKGVMLGGC-GDK 470 + + VRG G + + + I ++ + GV+ Sbjct: 369 VGGHKN-VGEVRGDGMLAAVEFVADKDDRVFFDASQKIGPQVATALAASGVIGRAMPQGD 427 Query: 471 SIRFRPTLVFRDHHAHLFLNIFSDILADF 499 + F P L A + ++ +D + Sbjct: 428 ILGFAPPLCLTREQADIVVSKTADAVKSV 456 >5LH9-A nrPDB Length = 458 Score = 337 bits (863), Expect = 9e-93, Method: Composition-based stats. Identities = 98/448 (21%), Positives = 164/448 (36%), Gaps = 54/448 (12%) Query: 75 CNYEESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGIL 134 GNY+ D+DG RMLD + ++ IG++ ++ + + + Sbjct: 37 LVIARGDGNYITDIDGQRMLDGVGGLWNVNIGHNRASVKAAIAAQLDELAYYQTFDGIAH 96 Query: 135 PPENFVEKLRESLLSV-APKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEE 193 P V L E L + A + M++++ + GS + E A K ++ + Sbjct: 97 P---RVFDLAERLTGMFAQERMARVLFSSGGSDAVETALKMARQYWIASGEP-------- 145 Query: 194 LETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKY 253 LS +HG MG + + H Y Sbjct: 146 ------------GRTRFLSLRNGYHGVHMGGTSVGGNGVYHYNHGQLLAGCHLLDTPWLY 193 Query: 254 PLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLR 313 ++ Q A C+ ++E+ I +T+A +I EP+Q GG D++ +LR Sbjct: 194 RNPWDCRDPQALTAHCIRQLEEQIALL--GAQTIAALIAEPVQGAGGVIVPPADYWPRLR 251 Query: 314 DISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGFFHKEEFRPN 373 ++ +HG + DEV TG G +G WG+ D++ +K + G Sbjct: 252 EVCDRHGILLIADEVVTGFGRSGCMLGSRGWGV--APDILCLAKGITAGYIPLGATLFNQ 309 Query: 374 APYR-------------IFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLL 420 T+ G P+ V++I++ EDL NAA G LL L Sbjct: 310 RIADAIENGQGFSHMIMHGYTYSGHPTACAAALAVLDIVEAEDLPGNAAKVGAQLLEQLQ 369 Query: 421 DLQARYPQFISRVRGRGTFCSFDT-----------PDESIRNKLISIARNKGVMLGGCGD 469 L RY + VRG+G + D P +++ AR GV++ G+ Sbjct: 370 PLVERY-AVVGEVRGKGLMIALDLVSDKRTRQPLDPAAGQPSRIADEARRAGVLVRPIGN 428 Query: 470 KSIRFRPTLVFRDHHAHLFLNIFSDILA 497 K I P L A L ++ A Sbjct: 429 KII-LSPPLTLTRDEAGLMVSALEAAFA 455 >3RUY-A nrPDB Length = 392 Score = 333 bits (855), Expect = 8e-92, Method: Composition-based stats. Identities = 87/434 (20%), Positives = 160/434 (36%), Gaps = 66/434 (15%) Query: 72 HFFCNYEESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPAL 131 ++ G ++ D +GNR +DL S S++ G+ HP ++ + N T +R Sbjct: 17 PLPIVISKAEGVWVEDPEGNRYMDLLSAYSAVNQGHRHPKIINALIDQANRVTLTSRAFH 76 Query: 132 --GILPPENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAF 189 + P V KL ++ M G+ + E A KT W ++ ++ Sbjct: 77 SDQLGPWYEKVAKLTNK---------EMVLPMNTGAEAVETAIKTARRWAYDVKKVEANR 127 Query: 190 SKEELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFP 249 + I+ FHGRTMG ++ + ++ + P I Sbjct: 128 A------------------EIIVCEDNFHGRTMGAVSMSSNEEYKRGFGPMLPGIIV--- 166 Query: 250 RLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFF 309 LE ++ I A I+EPIQ E G N F Sbjct: 167 ---------------IPYGDLEALKAAIT------PNTAAFILEPIQGEAGINIPPAGFL 205 Query: 310 RKLRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGFF---- 365 ++ ++ +K F+ DE+QTG G TGK +A + + D+ K + G F Sbjct: 206 KEALEVCKKENVLFVADEIQTGLGRTGKVFACDWDNVT--PDMYILGKALGGGVFPISCA 263 Query: 366 --HKEEFRPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDLQ 423 +++ P +T+ G+P + + +++ E L + G+ L+ L ++ Sbjct: 264 AANRDILGVFEPGSHGSTFGGNPLACAVSIAALEVLEEEKLTERSLQLGEKLVGQLKEI- 322 Query: 424 ARYPQFISRVRGRGTFCSFDTPDESIRNKLISIARNKGVMLGGCGDKSIRFRPTLVFRDH 483 I+ VRG+G F + + + + G++ + IR P LV + Sbjct: 323 --DNPMITEVRGKGLFIGIELNEPA--RPYCEQLKAAGLLCKETHENVIRIAPPLVISEE 378 Query: 484 HAHLFLNIFSDILA 497 +L+ Sbjct: 379 DLEWAFQKIKAVLS 392 >3FCR-A nrPDB Length = 458 Score = 333 bits (854), Expect = 1e-91, Method: Composition-based stats. Identities = 90/465 (19%), Positives = 170/465 (36%), Gaps = 62/465 (13%) Query: 65 IQNAEAVHFFCNYEESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVST 124 Q+A + + G ++ D DG ++LD ++ + + +GY + + + Sbjct: 24 AQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLYCVNVGYGRQEIAEAIADQARELA 83 Query: 125 FINRPALGILPPENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKER 184 + + + L + +L APK MS++ GS +NE K I WY + Sbjct: 84 YYHS---YVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLI--WYYNNIL 138 Query: 185 GQSAFSKEELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWP 244 G+ K I+S +HG + + T + HK FD P Sbjct: 139 GRPEKKK------------------IISRWRGYHGSGLVTGSLTGLELFHK----KFDLP 176 Query: 245 IAPFPRLKYPL----EEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGG 300 + + P E+ + +Q A C+ E+E LI R+ T+A I EPI GG Sbjct: 177 VEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIE--REGADTIAAFIGEPILGTGG 234 Query: 301 DNHASDDFFRKLRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMM 360 ++ ++ + KH + DEV TG G G + +H+GL+ D++T +K + Sbjct: 235 IVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLE--PDIITIAKGLT 292 Query: 361 TG-----GFFHKEEF--------RPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLSN 407 + G ++ N P T+ P + ++ +L+SN Sbjct: 293 SAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSN 352 Query: 408 AAHAGKVLLTGLLDLQARYPQFISRVRGRGTFCSFDTPD-----------ESIRNKLISI 456 A G L + + +++ + VRG G C+ + + I ++ + Sbjct: 353 AGEVGAYLNATMAEALSQHAN-VGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAK 411 Query: 457 ARNKGVMLGGCG--DKSIRFRPTLVFRDHHAHLFLNIFSDILADF 499 + ++ + F P A + + Sbjct: 412 LLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAV 456 >5EAV-A nrPDB Length = 441 Score = 332 bits (850), Expect = 3e-91, Method: Composition-based stats. Identities = 84/435 (19%), Positives = 155/435 (35%), Gaps = 58/435 (13%) Query: 71 VHFFCNYEESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPA 130 + +G + D++GN D + +SS+ G+ HP ++ + + T R A Sbjct: 50 APVPVVISKGKGARVWDINGNEYYDFLAGVSSLSQGHCHPRVIAALCRQAERLTLTLR-A 108 Query: 131 LGILPPENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFS 190 G + E G +++ M G+ + E+A K W + + Sbjct: 109 FGNDVTGPACRFMAEMF------GYDRVLLMNTGAEAGESALKIARKWAYEVKEIPPDSA 162 Query: 191 KEELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPR 250 K ++ + GRT+ +++ + + P Sbjct: 163 K------------------VILCNNNYWGRTITACSSSTTFDCYNNFGP----------- 193 Query: 251 LKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFR 310 F + + + +E+ + K VA VEPIQ EGG N + + Sbjct: 194 -------FTPGFELIDYDDVGALEEAL-----KDPNVAAFFVEPIQGEGGVNVPKPGYLK 241 Query: 311 KLRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGF------ 364 + ++ R +VDE+QTG TG+ A +H + D++ K + G Sbjct: 242 RAHELCRSKNVLLIVDEIQTGLCRTGRLLAADHDEVH--PDILLLGKSLSAGVVPISAVM 299 Query: 365 FHKEEFRPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDLQA 424 + P +T+ G+P + E + ++K E L A G L Sbjct: 300 GRADVMDVLKPGTHGSTFGGNPLACAVAVEALTVLKDEKLADRAERLGAQFRDCLRRELY 359 Query: 425 RYPQFISRVRGRGTFCSFDTPDESIR-NKLISIARNKGVMLGGCGDKSIRFRPTLVFRD- 482 +I +RGRG + + ++I N ++ + G++ + +RF P LV D Sbjct: 360 GKVPWIKEIRGRGLLNAVEVDSDAIDPNDVVMKLKENGILSKPTRGRVMRFIPPLVITDE 419 Query: 483 HHAHLFLNIFSDILA 497 H I LA Sbjct: 420 EHRDATTRIIKSFLA 434 >4FFC-A nrPDB Length = 453 Score = 330 bits (847), Expect = 7e-91, Method: Composition-based stats. Identities = 113/467 (24%), Positives = 188/467 (40%), Gaps = 54/467 (11%) Query: 46 MKTEVPGPRSRELMKQLNIIQNAE-AVHFFCNYEESRGNYLVDVDGNRMLDLYSQISSIP 104 + T +PGPRS L ++ +A ++ G +VD DGN +DL + I+ Sbjct: 18 IVTPLPGPRSGALAERRRAAVSAGVGSTAPVYAVDADGGVIVDADGNSFIDLGAGIAVTT 77 Query: 105 IGYSHPALVKLVQQPQNVSTFINRPALGILPPENFVEKLRESLLSVAPKGMS-QLITMAC 163 +G SHPA + + +T + P E +V ++ E L ++ P + Sbjct: 78 VGASHPA---VAAAIADQATHFTHTCFMVTPYEQYV-QVAELLNALTPGDHDKRTALFNS 133 Query: 164 GSCSNENAFKTIFMWYRSKERGQSAFSKEELETCMINQAPGCPDYSILSFMGAFHGRTMG 223 G+ + ENA K A G P ++++F A+HGRT Sbjct: 134 GAEAVENAIKVAR------------------------LATGRP--AVVAFDNAYHGRTNL 167 Query: 224 CLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKK 283 +A T +K F + P +E ++ R + +E I Sbjct: 168 TMALTAKSMPYKSQFGPFAPEVYRMPASYPLRDEPGLTGEEAARRAISRIETQI-----G 222 Query: 284 KKTVAGIIVEPIQSEGGDNHASDDFFRKLRDISRKHGCAFLVDEVQTGGGSTGKFWAHEH 343 +++A II+EPIQ EGG + F L + ++G F+ DEVQTG TG ++A EH Sbjct: 223 AQSLAAIIIEPIQGEGGFIVPAPGFLATLTAWASENGVVFIADEVQTGFARTGAWFASEH 282 Query: 344 WGLDDPADVMTFSKKMMTGGFFHKEEFRPNA-----PYRIFNTWLGDPSKNLLLAEVINI 398 G+ D++T +K + G R + T+ G+P + + Sbjct: 283 EGI--VPDIVTMAKGIAGGMPLSAVTGRAELMDAVYAGGLGGTYGGNPVTCAAAVAALGV 340 Query: 399 IKREDLLSNAAHAGKVLLTGLLDLQARYPQFISRVRGRGTFCSFD-------TPDESIRN 451 ++ DL + A + + L L I VRGRG + + PD ++ Sbjct: 341 MRELDLPARARAIEASVTSRLSALAEE-VDIIGEVRGRGAMLAIEIVKPGTLEPDAALTK 399 Query: 452 KLISIARNKGVMLGGCG--DKSIRFRPTLVFRDHHAHLFLNIFSDIL 496 + + A ++GV++ CG IR P LV D + SDI+ Sbjct: 400 SIAAEALSQGVLILTCGTFGNVIRLLPPLVIGDDLLDEGITALSDII 446 >1WKH-A nrPDB Length = 395 Score = 330 bits (845), Expect = 1e-90, Method: Composition-based stats. Identities = 92/447 (20%), Positives = 163/447 (36%), Gaps = 66/447 (14%) Query: 56 RELMKQLNIIQNAEAVHFFCNYEESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKL 115 R L++ + + +G + D +GN +D +G+ +P +V+ Sbjct: 10 RALLEAEKTLDSGVYNKHDLLIVRGQGARVWDAEGNEYIDCVGGYGVANLGHGNPEVVEA 69 Query: 116 VQQPQNVSTFINRPALGILPPENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTI 175 V++ A+ P + +L ++ P ++++ + G+ +NE A K Sbjct: 70 VKRQAETL-----MAMPQTLPTPMRGEFYRTLTAILPPELNRVFPVNSGTEANEAALKFA 124 Query: 176 FMWYRSKERGQSAFSKEELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHK 235 K ++ M F GRTMG L+ T + Sbjct: 125 RAHTGRK--------------------------KFVAAMRGFSGRTMGSLSVTWEPKYRE 158 Query: 236 IDIPSFDWPIAPFPRLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPI 295 +P + P + Y +E ++ + + A +I+EP+ Sbjct: 159 PFLPL----VEPVEFIPY--------------NDVEALKRAV------DEETAAVILEPV 194 Query: 296 QSEGGDNHASDDFFRKLRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTF 355 Q EGG A+ +F R R+I+++ G ++DE+QTG G TGK +A EH+G+ D++T Sbjct: 195 QGEGGVRPATPEFLRAAREITQEKGALLILDEIQTGMGRTGKRFAFEHFGI--VPDILTL 252 Query: 356 SKKMMTGGFFHKEEFRPNAP-----YRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAH 410 +K + G R T+ G+P I ++R L AA Sbjct: 253 AKALGGGVPLGVAVMREEVARSMPKGGHGTTFGGNPLAMAAGVAAIRYLERTRLWERAAE 312 Query: 411 AGKVLLTGLLDLQARYPQFISRVRGRGTFCSFDTPDESIRNKLISIARNKGVMLGGCGDK 470 G + L + I VRG G + E + + + V+ G Sbjct: 313 LGPWFMEKLRAIP---SPKIREVRGMGLMVGLEL-KEKAAPYIARLEKEHRVLALQAGPT 368 Query: 471 SIRFRPTLVFRDHHAHLFLNIFSDILA 497 IRF P LV + +LA Sbjct: 369 VIRFLPPLVIEKEDLERVVEAVRAVLA 395 >3DOD-A nrPDB Length = 448 Score = 329 bits (843), Expect = 2e-90, Method: Composition-based stats. Identities = 83/452 (18%), Positives = 163/452 (36%), Gaps = 61/452 (13%) Query: 74 FCNYEESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGI 133 E G + D++G D +S + G+ L +++ + Sbjct: 27 PLIIESGTGIKVKDINGKEYYDGFSSVWLNVHGHRKKELDDAIKKQLGKIAHSTLLGMTN 86 Query: 134 LPPENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEE 193 +P +L E+L+ ++PK ++++ G+ + E A K F ++++ + + Sbjct: 87 VP----ATQLAETLIDISPKKLTRVFYSDSGAEAMEIALKMAFQYWKNIGKPEKQ----- 137 Query: 194 LETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIP-SFDWPIAPFPRLK 252 ++ +HG T+G ++ + H + P F+ AP P Sbjct: 138 ---------------KFIAMKNGYHGDTIGAVSVGSIELFHHVYGPLMFESYKAPIP--- 179 Query: 253 YPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEP-IQSEGGDNHASDDFFRK 311 Y + + +CL E+ L+ ++ + +A + +E +Q G + + Sbjct: 180 YVYRSESGDPDECRDQCLRELAQLLEEHH---EEIAALSIESMVQGASGMIVMPEGYLAG 236 Query: 312 LRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGFFHKEEFR 371 +R++ + +VDEV TG G TGK +A EH + D+M K + G F Sbjct: 237 VRELCTTYDVLMIVDEVATGFGRTGKMFACEHENVQ--PDLMAAGKGITGGYLPIAVTFA 294 Query: 372 PNAPY-------------RIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTG 418 Y +++ G+ + E + + + E+++ A K L Sbjct: 295 TEDIYKAFYDDYENLKTFFHGHSYTGNQLGCAVALENLALFESENIVEQVAEKSKKLHFL 354 Query: 419 LLDLQARYPQFISRVRGRGTFCSFDTP-----------DESIRNKLISIARNKGVMLGGC 467 L DL A + +R G C + D I K+ R G++ Sbjct: 355 LQDLHA--LPHVGDIRQLGFMCGAELVRSKETKEPYPADRRIGYKVSLKMRELGMLTRPL 412 Query: 468 GDKSIRFRPTLVFRDHHAHLFLNIFSDILADF 499 GD I F P L + I + + Sbjct: 413 GD-VIAFLPPLASTAEELSEMVAIMKQAIHEV 443 >4ADC-A nrPDB Length = 406 Score = 327 bits (838), Expect = 7e-90, Method: Composition-based stats. Identities = 96/428 (22%), Positives = 160/428 (37%), Gaps = 61/428 (14%) Query: 79 ESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGILPPEN 138 G+ L D G +D I+ +G++HP L + + + S F + G Sbjct: 27 RGEGSRLWDQQGKEYIDFAGGIAVNALGHAHPELREALNEQA--SKFWHT---GNGYTNE 81 Query: 139 FVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELETCM 198 V +L + L+ ++ G+ +NE A K + Sbjct: 82 PVLRLAKKLIDATFA--DRVFFCNSGAEANEAALKLARKF-------------------- 119 Query: 199 INQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEF 258 + G I++F AFHGRT+ ++ P++ AP P Sbjct: 120 AHDRYGSHKSGIVAFKNAFHGRTLFTVSAGGQ--------PAYSQDFAPLPADIR----- 166 Query: 259 VKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDISRK 318 + LI + +IVEPIQ EGG AS+ F + LR++ + Sbjct: 167 -----HAAYNDINSASALI------DDSTCAVIVEPIQGEGGVVPASNAFLQGLRELCNR 215 Query: 319 HGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGFFHK-----EEFRPN 373 H + DEVQTG G TG+ +A+ H+G+ D++T +K + G E R Sbjct: 216 HNALLIFDEVQTGVGRTGELYAYMHYGVT--PDLLTTAKALGGGFPVGALLATEECARVM 273 Query: 374 APYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDLQARYPQFISRV 433 T+ G+P + + +V+ +I ++L+ + L + RY F S V Sbjct: 274 TVGTHGTTYGGNPLASAVAGKVLELINTPEMLNGVKQRHDWFVERLNTINHRYGLF-SEV 332 Query: 434 RGRGTFCS--FDTPDESIRNKLISIARNKGVMLGGCGDKSIRFRPTLVFRDHHAHLFLNI 491 RG G + ++ A GVM+ G +RF P L + L+ Sbjct: 333 RGLGLLIGCVLNADYAGQAKQISQEAAKAGVMVLIAGGNVVRFAPALNVSEEEVTTGLDR 392 Query: 492 FSDILADF 499 F+ F Sbjct: 393 FAAACEHF 400 >4E3Q-A nrPDB Length = 473 Score = 325 bits (833), Expect = 3e-89, Method: Composition-based stats. Identities = 92/488 (18%), Positives = 155/488 (31%), Gaps = 76/488 (15%) Query: 53 PRSRELMKQLNIIQNAEAVHFF-------------CNYEESRGNYLVDVDGNRMLDLYSQ 99 PR + K + AE + G Y+VDV+G R LD S Sbjct: 16 PRGSHMNKPQSWEARAETYSLYGFTDMPSLHQRGTVVVTHGEGPYIVDVNGRRYLDANSG 75 Query: 100 ISSIPIGYSHPALVKLVQQPQNVSTFINRPALGILPPENFVEKLRESLLSVAPKGMSQLI 159 + ++ G+ H L+ + + + L E L+ V+P ++ Sbjct: 76 LWNMVAGFDHKGLIDAAKAQYERFPGYHAFF---GRMSDQTVMLSEKLVEVSPFDSGRVF 132 Query: 160 TMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELETCMINQAPGCPDYSILSFMGAFHG 219 GS +N+ K + W+ G+ K IL+ A+HG Sbjct: 133 YTNSGSEANDTMVKML--WFLHAAEGKPQKRK------------------ILTRWNAYHG 172 Query: 220 RTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYP-LEEFVKENQQEE---ARCLEEVED 275 T + T F P+ F L P + +E + EE AR E+E+ Sbjct: 173 VTAVSASMTGKP-----YNSVFGLPLPGFVHLTCPHYWRYGEEGETEEQFVARLARELEE 227 Query: 276 LIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDISRKHGCAFLVDEVQTGGGST 335 I R+ T+AG EP+ GG + +F+ + I RK+ + DEV G G T Sbjct: 228 TIQ--REGADTIAGFFAEPVMGAGGVIPPAKGYFQAILPILRKYDIPVISDEVICGFGRT 285 Query: 336 GKFWAHEHWGLDDPADVMTFSKKMMTGGFFHKEEFR-------------PNAPYRIFNTW 382 G W + D + SK + G F + T Sbjct: 286 GNTWGCVTYDFT--PDAIISSKNLTAGFFPMGAVILGPELSKRLETAIEAIEEFPHGFTA 343 Query: 383 LGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDLQARYPQFISRVRGRGTFCSF 442 G P + + I+++ E L N L + R I RG G + Sbjct: 344 SGHPVGCAIALKAIDVVMNEGLAENVRRLAPRFEERLKHIAER--PNIGEYRGIGFMWAL 401 Query: 443 DTPDESIRN-----------KLISIARNKGVMLGGCGDKSIRFRPTLVFRDHHAHLFLNI 491 + + ++ + + G++ G + P + + + Sbjct: 402 EAVKDKASKTPFDGNLSVSERIANTCTDLGLICRPLGQSVV-LCPPFILTEAQMDEMFDK 460 Query: 492 FSDILADF 499 L Sbjct: 461 LEKALDKV 468 >4UHN-A nrPDB Length = 468 Score = 323 bits (828), Expect = 9e-89, Method: Composition-based stats. Identities = 82/484 (16%), Positives = 159/484 (32%), Gaps = 69/484 (14%) Query: 53 PRSRELMKQLNIIQNAEA--------VHFFCNYE---------ESRGNYLVDVDGNRMLD 95 PR + +Q+N+ +A A + F N + G++LVD G R+ D Sbjct: 16 PRGSHMNQQVNVAPSAAADLNLKAHWMPFSANRNFHKDPRIIVAAEGSWLVDDKGRRIYD 75 Query: 96 LYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGILPPENFVEKLRESLLSVAPKGM 155 S + + G+S + V + + T P P +F +L E + + P + Sbjct: 76 SLSGLWTCGAGHSRKEIADAVAKQ--IGTLDYSPGFQYGHPLSF--QLAEKIAQMTPGTL 131 Query: 156 SQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELETCMINQAPGCPDYSILSFMG 215 + GS + + K ++R K + Q ++ Sbjct: 132 DHVFFTGSGSECADTSIKMARAYWRIKGQAQKT--------------------KLIGRAR 171 Query: 216 AFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFVKENQQEEARCLEEVED 275 +HG + + K+ P D + P P F K + L E Sbjct: 172 GYHGVNVAGTSLGGIGGNRKMFGPLMD--VDHLPHTLQPGMAFTKGAAETGGVELAN-EL 228 Query: 276 LIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDISRKHGCAFLVDEVQTGGGST 335 L + +A +IVEP+ G + ++LR+I + + DEV T G Sbjct: 229 LKLIELHDASNIAAVIVEPMSGSAGVIVPPKGYLQRLREICDANDILLIFDEVITAFGRM 288 Query: 336 GKFWAHEHWGLDDPADVMTFSKKMMTGGFFHKEEFRPNAPY---------------RIFN 380 GK E++G+ D+M +K++ G + Y Sbjct: 289 GKATGAEYFGVT--PDIMNVAKQVTNGAVPMGAVIASSEIYDTFMNQNLPEYAVEFGHGY 346 Query: 381 TWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDLQARYPQFISRVRGRGTFC 440 T+ P ++++++E+L+ +A L L+ + + +R G Sbjct: 347 TYSAHPVACAAGIAALDLLQKENLIQQSAELAPHFEKALHGLKG--TKNVIDIRNCGLAG 404 Query: 441 SFDTPDESIRNKL-----ISIARNKGVMLGGCGDKSIRFRPTLVFRDHHAHLFLNIFSDI 495 + + +G + G +++F PT + + + Sbjct: 405 AIQIAARDGDAIVRPFEASMKLWKEGFYVR-FGGDTLQFGPTFNAKPEDLDRLFDAVGEA 463 Query: 496 LADF 499 L Sbjct: 464 LNGV 467 >4ATP-A nrPDB Length = 456 Score = 323 bits (827), Expect = 1e-88, Method: Composition-based stats. Identities = 110/470 (23%), Positives = 190/470 (40%), Gaps = 56/470 (11%) Query: 49 EVPGPRSRELMKQLNIIQNAEAVH-FFCNYEESRGNYLVDVDGNRMLDLYSQISSIPIGY 107 PGP+S+ L ++ + + A E++ G + DVDGN +DL S I+ +G Sbjct: 21 AFPGPKSQALAERRSAVVAAGVASGVPVYVEDADGGIIRDVDGNSFIDLGSGIAVTSVGA 80 Query: 108 SHPALVKLVQQPQNVSTFINRPALGILPPENFVEKLRESLLSVAPKGM-SQLITMACGSC 166 S PA +V Q + + P E +V + E L + P + + G+ Sbjct: 81 SDPA---VVAAVQEAAAHFTHTCFMVTPYEGYVA-VTEQLNRLTPGDHAKRTVLFNSGAE 136 Query: 167 SNENAFKTIFMWYRSKERGQSAFSKEELETCMINQAPGCPDYSILSFMGAFHGRTMGCLA 226 + ENA K ++++F A+HGRT +A Sbjct: 137 AVENAVKVAR--------------------------LATGRDAVVAFDHAYHGRTNLTMA 170 Query: 227 TTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKT 286 T +K + F + P + YP E E EA + +++ + Sbjct: 171 LTAKAMPYKTNFGPFAPEVYRMP-MSYPFREENPEITGAEA---AKRAITMIEKQIGGDQ 226 Query: 287 VAGIIVEPIQSEGGDNHASDDFFRKLRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGL 346 VA II+EPIQ EGG ++ F L + +++ G F+ DEVQ+G TG+++A +H G+ Sbjct: 227 VAAIIIEPIQGEGGFIVPAEGFLPALSEWAKEKGIVFIADEVQSGFCRTGEWFAVDHEGV 286 Query: 347 DDPADVMTFSKKMMTGGFFHKEEFRPN-----APYRIFNTWLGDPSKNLLLAEVINIIKR 401 D++T +K + G R + P + T+ G+P I+ +++ Sbjct: 287 --VPDIITMAKGIAGGLPLSAITGRADLLDAVHPGGLGGTYGGNPVACAAALAAIDTMEQ 344 Query: 402 EDLLSNAAHAGKVLLTGLLDLQARYP----QFISRVRGRGTFCSFDT-------PDESIR 450 DL A H ++ L L +L A + +RGRG + + P+ + Sbjct: 345 HDLNGRARHIEELALGKLRELAAELSAGGGSVVGDIRGRGAMLAIELVQPGSKEPNAELT 404 Query: 451 NKLISIARNKGVMLGGCG--DKSIRFRPTLVFRDHHAHLFLNIFSDILAD 498 + + +GV++ CG IR P LV D L + + + Sbjct: 405 KAVAAACLKEGVIILTCGTYGNVIRLLPPLVISDELLIDGLEVLAAAIKA 454 >3NX3-A nrPDB Length = 395 Score = 322 bits (826), Expect = 2e-88, Method: Composition-based stats. Identities = 98/434 (22%), Positives = 160/434 (36%), Gaps = 61/434 (14%) Query: 72 HFFCNYEESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPAL 131 F E+ +G YL D + LD S I +GY+H ++ + ++ L Sbjct: 17 RFDIVLEKGQGVYLFDDKAKKYLDFSSGIGVCALGYNHAKFNAKIKAQVDK--LLHTSNL 74 Query: 132 GILPPENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSK 191 K + ++ G+ S E A KT + +K Sbjct: 75 YYNENIAAAAK-----NLAKASALERVFFTNSGTESIEGAMKTARKYAFNK--------- 120 Query: 192 EELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRL 251 G ++F +FHGRT+G L+ T ++ K P I+ Sbjct: 121 ------------GVKGGQFIAFKHSFHGRTLGALSLTANEKYQKPFKPL----ISGVKFA 164 Query: 252 KYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRK 311 KY + VE L+ + II+E +Q EGG N A+ DF++ Sbjct: 165 KY--------------NDISSVEKLVN------EKTCAIILESVQGEGGINPANKDFYKA 204 Query: 312 LRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSK----KMMTGGFFHK 367 LR + + + DE+Q G G +GKF+A+EH D+MT +K + G F Sbjct: 205 LRKLCDEKDILLIADEIQCGMGRSGKFFAYEH--AQILPDIMTSAKALGCGLSVGAFVIN 262 Query: 368 EEFRPNA--PYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDLQAR 425 ++ N+ +T+ G+P + V I K E +L N L L +L Sbjct: 263 QKVASNSLEAGDHGSTYGGNPLVCAGVNAVFEIFKEEKILENVNKLTPYLEQSLDELINE 322 Query: 426 YPQFISRVRGRGTFCSFDTPDESIRNKLISIARNKGVMLGGCGDKSIRFRPTLVFRDHHA 485 + F + +G G K+I + ++L CG+ +RF P L+ + H Sbjct: 323 F-DFCKKRKGLGFMQGLSLDKSVKVAKVIQKCQENALLLISCGENDLRFLPPLILQKEHI 381 Query: 486 HLFLNIFSDILADF 499 L F Sbjct: 382 DEMSEKLRKALKSF 395 >4JF0-A nrPDB Length = 422 Score = 322 bits (825), Expect = 3e-88, Method: Composition-based stats. Identities = 90/460 (19%), Positives = 161/460 (35%), Gaps = 69/460 (15%) Query: 55 SRELMKQLNIIQNA--EAVHFFCNY------EESRGNYLVDVDGNRMLDLYSQISSIPIG 106 + + + I A + V + +G+ + D G +D I+ +G Sbjct: 13 ASHMATEQTAITRATFDEVILPVYAPADFIPVKGKGSRVWDQQGKEYIDFAGGIAVTALG 72 Query: 107 YSHPALVKLVQQPQNVSTFINRPALGILPPENFVEKLRESLLSVAPKGMSQLITMACGSC 166 + HPALV+ ++ +R +L L+ +++ M G+ Sbjct: 73 HCHPALVEALKSQGETLWHTSRVF-----TNEPALRLGRKLIDATFA--ERVLFMNSGTE 125 Query: 167 SNENAFKTIFMWYRSKERGQSAFSKEELETCMINQAPGCPDYSILSFMGAFHGRTMGCLA 226 +NE AFK + + I++F AFHGR++ ++ Sbjct: 126 ANETAFKLARHYACVRHSPFKT--------------------KIIAFHNAFHGRSLFTVS 165 Query: 227 TTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKT 286 P P + P DL Sbjct: 166 VGGQPKYSDGFGPK------PADIIHVPFN------------------DLHAVKAVMDDH 201 Query: 287 VAGIIVEPIQSEGGDNHASDDFFRKLRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGL 346 ++VEPIQ EGG A+ +F + LRD+ +H + DEVQ G G TG +A+ H+G+ Sbjct: 202 TCAVVVEPIQGEGGVQAATPEFLKGLRDLCDEHQALLVFDEVQCGMGRTGDLFAYMHYGV 261 Query: 347 DDPADVMTFSKKMMTGGFFHK-----EEFRPNAPYRIFNTWLGDPSKNLLLAEVINIIKR 401 D++T +K + G E +T+ G+P + +II Sbjct: 262 T--PDILTSAKALGGGFPVSAMLTTQEIASAFHVGSHGSTYGGNPLACAVAGATFDIINT 319 Query: 402 EDLLSNAAHAGKVLLTGLLDLQARYPQFISRVRGRGTFCSFDT-PDESIRNK-LISIARN 459 ++L + + L + ++ S +RG G + P R + + Sbjct: 320 PEVLQGIHTKRQQFVQHLQAIDEQF-DIFSDIRGMGLLIGAELKPKYKGRARDFLYAGAE 378 Query: 460 KGVMLGGCGDKSIRFRPTLVFRDHHAHLFLNIFSDILADF 499 GVM+ G +RF P+LV + H + F+ + Sbjct: 379 AGVMVLNAGADVMRFAPSLVVEEADIHEGMQRFAQAVGKV 418 >4GRX-A nrPDB Length = 465 Score = 317 bits (811), Expect = 9e-87, Method: Composition-based stats. Identities = 88/456 (19%), Positives = 147/456 (32%), Gaps = 63/456 (13%) Query: 72 HFFCNYEESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPAL 131 G Y+VDV G R LD S + ++ G+ H L++ + + + Sbjct: 40 RGTVVVTHGEGPYIVDVHGRRYLDANSGLWNMVAGFDHKGLIEAAKAQYDRFPGYHAFF- 98 Query: 132 GILPPENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSK 191 + L E L+ V+P ++ GS +N+ K + W+ G+ K Sbjct: 99 --GRMSDQTVMLSEKLVEVSPFDNGRVFYTNSGSEANDTMVKML--WFLHAAEGKPQKRK 154 Query: 192 EELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRL 251 IL+ A+HG T + T F P+ F L Sbjct: 155 ------------------ILTRWNAYHGVTAVSASMTGKP-----YNSVFGLPLPGFIHL 191 Query: 252 KYP-LEEFVKENQQEE---ARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDD 307 P + +E + E AR E+ED I R+ T+AG EP+ GG + Sbjct: 192 TCPHYWRYGEEGETEAQFVARLARELEDTIT--REGADTIAGFFAEPVMGAGGVIPPAKG 249 Query: 308 FFRKLRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGFFHK 367 +F+ + I RK+ + DEV G G TG W + D + SK + G F Sbjct: 250 YFQAILPILRKYDIPMISDEVICGFGRTGNTWGCLTYDF--MPDAIISSKNLTAGFFPMG 307 Query: 368 EEFR-------------PNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKV 414 + T G P + + I+++ E L N Sbjct: 308 AVILGPDLAKRVEAAVEAIEEFPHGFTASGHPVGCAIALKAIDVVMNEGLAENVRRLAPR 367 Query: 415 LLTGLLDLQARYPQFISRVRGRGTFCSFDTPDESIRN-----------KLISIARNKGVM 463 GL + R I RG G + + + ++ + + G++ Sbjct: 368 FEAGLKRIADR--PNIGEYRGIGFMWALEAVKDKPTKTPFDANLSVSERIANTCTDLGLI 425 Query: 464 LGGCGDKSIRFRPTLVFRDHHAHLFLNIFSDILADF 499 G + P + + L Sbjct: 426 CRPLGQSIV-LCPPFILTEAQMDEMFEKLEKALDKV 460 >2JJG-A nrPDB Length = 449 Score = 316 bits (810), Expect = 1e-86, Method: Composition-based stats. Identities = 116/439 (26%), Positives = 186/439 (42%), Gaps = 35/439 (7%) Query: 69 EAVHFFCNYEESRGNYLVD-VDGNRMLDLYSQISSIPIGYSHPALVKLVQ-QPQNVSTFI 126 + + + S G+YLVD + G R LD+++ ++S +G + PALV + + + + Sbjct: 31 DGLDIVLDLTRSGGSYLVDAITGRRYLDMFTFVASSALGMNPPALVDDREFHAELMQAAL 90 Query: 127 NRPA---LGILPPENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKE 183 N+P+ + + FVE L A + L + G+ + ENA K F W Sbjct: 91 NKPSNSDVYSVAMARFVETFARVLGDPA---LPHLFFVEGGALAVENALKAAFDW----- 142 Query: 184 RGQSAFSKEELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDW 243 + + +L GAFHGR+ L+ T++K P FDW Sbjct: 143 ---------KSRHNQAHGIDPALGTQVLHLRGAFHGRSGYTLSLTNTKPTITARFPKFDW 193 Query: 244 PIAPFPRLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNH 303 P R+ P + A E + + + +A + EPIQ EGGD H Sbjct: 194 P-----RIDAPYMRPGLDEPAMAALEAEALRQARAAFETRPHDIACFVAEPIQGEGGDRH 248 Query: 304 ASDDFFRKLRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGG 363 +FF +R++ + + DEVQTG G TG WA++ LD D++ F KK G Sbjct: 249 FRPEFFAAMRELCDEFDALLIFDEVQTGCGLTGTAWAYQQ--LDVAPDIVAFGKKTQVCG 306 Query: 364 FFHKEEFRPNA------PYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLT 417 A P R+ +TW G+ + + ++ +I+ E L A GK L Sbjct: 307 VMAGRRVDEVADNVFAVPSRLNSTWGGNLTDMVRARRILEVIEAEGLFERAVQHGKYLRA 366 Query: 418 GLLDLQARYPQFISRVRGRGTFCSFDTPDESIRNKLISIARNKGVMLGGCGDKSIRFRPT 477 L +L A +P + RGRG C+F P + R++LI + V++ G ++RFRP Sbjct: 367 RLDELAADFPAVVLDPRGRGLMCAFSLPTTADRDELIRQLWQRAVIVLPAGADTVRFRPP 426 Query: 478 LVFRDHHAHLFLNIFSDIL 496 L + L Sbjct: 427 LTVSTAEIDAAIAAVRSAL 445 >4BQ0-A nrPDB Length = 448 Score = 312 bits (798), Expect = 3e-85, Method: Composition-based stats. Identities = 82/477 (17%), Positives = 158/477 (33%), Gaps = 58/477 (12%) Query: 44 PLMKTEVPGPRSRELMKQLNIIQNAEAVHF---FCNYEESRGNYLVDVDGNRMLDLYSQI 100 PL P S EL + + + + +F + G++L D G ++ D S + Sbjct: 4 PLNVAP---PVSSELNLRAHWMPFSANRNFQKDPRIIVAAEGSWLTDDKGRKVYDSLSGL 60 Query: 101 SSIPIGYSHPALVKLVQQPQNVSTFINRPALGILPPENFVEKLRESLLSVAPKGMSQLIT 160 + G+S + + V + + T P P +F +L E + + P ++ + Sbjct: 61 WTCGAGHSRKEIQEAVARQ--LGTLDYSPGFQYGHPLSF--QLAEKIAGLLPGELNHVFF 116 Query: 161 MACGSCSNENAFKTIFMWYRSKERGQSAFSKEELETCMINQAPGCPDYSILSFMGAFHGR 220 GS + + K ++R K + Q ++ +HG Sbjct: 117 TGSGSECADTSIKMARAYWRLKGQPQKT--------------------KLIGRARGYHGV 156 Query: 221 TMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFVKENQQEEARCLEEVEDLIVKY 280 + + K+ D + P P F + Q L E L + Sbjct: 157 NVAGTSLGGIGGNRKMFGQLMD--VDHLPHTLQPGMAFTRGMAQTGGVELAN-ELLKLIE 213 Query: 281 RKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDISRKHGCAFLVDEVQTGGGSTGKFWA 340 +A +IVEP+ G + ++LR+I +H + DEV T G G + Sbjct: 214 LHDASNIAAVIVEPMSGSAGVLVPPVGYLQRLREICDQHNILLIFDEVITAFGRLGTYSG 273 Query: 341 HEHWGLDDPADVMTFSKKMMTGGFFHKEEFRPNAPYR---------------IFNTWLGD 385 E++G+ D+M +K++ G + Y T+ Sbjct: 274 AEYFGVT--PDLMNVAKQVTNGAVPMGAVIASSEIYDTFMNQALPEHAVEFSHGYTYSAH 331 Query: 386 PSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDLQARYPQFISRVRGRGTFCSFDTP 445 P ++I+ R++L+ +A GL LQ + + +R G + Sbjct: 332 PVACAAGLAALDILARDNLVQQSAELAPHFEKGLHGLQGA--KNVIDIRNCGLAGAIQIA 389 Query: 446 DESIRNKL-----ISIARNKGVMLGGCGDKSIRFRPTLVFRDHHAHLFLNIFSDILA 497 + +G + G +++F PT R + + L Sbjct: 390 PRDGDPTVRPFEAGMKLWQQGFYVR-FGGDTLQFGPTFNARPEELDRLFDAVGEALN 445 >1ZOD-A nrPDB Length = 433 Score = 310 bits (794), Expect = 1e-84, Method: Composition-based stats. Identities = 100/443 (22%), Positives = 166/443 (37%), Gaps = 57/443 (12%) Query: 74 FCNYEESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGI 133 E ++G+++ D DG +LD S S +G+ HP +V ++ + + L Sbjct: 26 PMIIERAKGSFVYDADGRAILDFTSGQMSAVLGHCHPEIVSVIGEYAGKLDHLFSEMLS- 84 Query: 134 LPPENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEE 193 V L L ++ P G+ + + ++ G+ SNE A + Sbjct: 85 ----RPVVDLATRLANITPPGLDRALLLSTGAESNEAAIRMA------------------ 122 Query: 194 LETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKY 253 Y I+ F ++HG T + T+S + + P P Sbjct: 123 --------KLVTGKYEIVGFAQSWHGMTGAAASATYSAGRKGVGPAAVGSFAIPAPFTYR 174 Query: 254 PLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLR 313 P F + + L+ DLI R+ +A I EPI S GG D + L+ Sbjct: 175 P--RFERNGAYDYLAELDYAFDLID--RQSSGNLAAFIAEPILSSGGIIELPDGYMAALK 230 Query: 314 DISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGFFHK------ 367 G ++DE QTG G TG +A + G+ D++T SK + G Sbjct: 231 RKCEARGMLLILDEAQTGVGRTGTMFACQRDGVT--PDILTLSKTLGAGLPLAAIVTSAA 288 Query: 368 -EEFRPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDLQARY 426 EE Y + T + DP + V+++++R+ L++ A G L GLLDL R+ Sbjct: 289 IEERAHELGYLFYTTHVSDPLPAAVGLRVLDVVQRDGLVARANVMGDRLRRGLLDLMERF 348 Query: 427 PQFISRVRGRGTFCSFD--------TPDESIRNKLISIARNKGV----MLGGCGDKSIRF 474 I VRGRG + P + + K+ N G+ + R Sbjct: 349 -DCIGDVRGRGLLLGVEIVKDRRTKEPADGLGAKITRECMNLGLSMNIVQLPGMGGVFRI 407 Query: 475 RPTLVFRDHHAHLFLNIFSDILA 497 P L + L L++ + Sbjct: 408 APPLTVSEDEIDLGLSLLGQAIE 430 >5M46-A nrPDB Length = 440 Score = 305 bits (780), Expect = 3e-83, Method: Composition-based stats. Identities = 103/465 (22%), Positives = 171/465 (36%), Gaps = 57/465 (12%) Query: 51 PGPRSRELMKQLNIIQNAEAVHFFC-NYEESRGNYLVDVDGNRMLDLYSQISSIPIGYSH 109 P + I + + + FF +G LV+ DG ++DL + +GY H Sbjct: 3 PAMAGNLYGRDGAAIGSLQKLRFFPLAVAGGQGARLVEEDGRELIDLSGAWGAASLGYGH 62 Query: 110 PALVKLVQQPQNVSTFINRPALGILPPENFVEKLRESLLSVAPK-GMSQLITMACGSCSN 168 PA+++ V + + + P L E L + P G ++ GS +N Sbjct: 63 PAIIEAVSRAAANPAGASILSASNAP----AVALAERLTASFPGRGTHKVWFGHSGSDAN 118 Query: 169 ENAFKTIFMWYRSKERGQSAFSKEELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATT 228 E A++ I +++F+GA+HG T+G +A + Sbjct: 119 EAAYRAITRATGRTG--------------------------VIAFIGAYHGCTVGSMAFS 152 Query: 229 HSKAIHKIDIPSFDWPIAPFPRLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVA 288 ++ + + P+P P ++ + +A E L ++A Sbjct: 153 G-HSVQADAAKADGLILLPYPDPYRPYQD----DPTGDAVLALLKERLAAV---PAGSIA 204 Query: 289 GIIVEPIQSEGGDNHASDDFFRKLRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDD 348 +EPIQS+GG D F RK DI R HG + + DEV+ G +G+ EH G Sbjct: 205 AAFIEPIQSDGGLIVPPDGFLRKFADICRAHGISVVCDEVKVGLARSGRLHCFEHEGF-- 262 Query: 349 PADV----MTFSKKMMTGGFFHKEEFRPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDL 404 D+ + E A T G+P V+ I+ E+L Sbjct: 263 VPDILVLGKGLGGGLPLSAVIAPAEILDCASAFAMQTLHGNPVCAAAGLAVLETIEAENL 322 Query: 405 LSNAAHAGKVLLTGLLDLQARYPQFISRVRGRGTFCSFDT--------PDESIRNKLISI 456 + A GK+L GL L R+ + I +RGRG C + P + KLI Sbjct: 323 TTAAERKGKLLREGLARLAERH-ELIGDIRGRGLACGVELVRNRQSREPARAETAKLIYR 381 Query: 457 ARNKGVML--GGCGDKSIRFRPTLVFRDHHAHLFLNIFSDILADF 499 A G++L G + P L + +N+ + Sbjct: 382 AYELGLVLYYVGMNGNVLEMTPPLTMTEDEVRHAVNLLDQAFTEL 426 >3I5T-A nrPDB Length = 476 Score = 304 bits (779), Expect = 5e-83, Method: Composition-based stats. Identities = 82/452 (18%), Positives = 149/452 (32%), Gaps = 62/452 (13%) Query: 75 CNYEESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGIL 134 + G Y+ DG R++D + + +GY +V + V + + + Sbjct: 38 PVLTHAEGIYVHTEDGRRLIDGPAGMWCAQVGYGRREIVDAMAHQAMVLPYASPWYMATS 97 Query: 135 PPENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEEL 194 P +L E + ++ P ++++ GS + ++A + + R Q Sbjct: 98 P----AARLAEKIATLTPGDLNRIFFTTGGSTAVDSALRFSEFYNNVLGRPQKKR----- 148 Query: 195 ETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYP 254 I+ +HG T A T P+FD L P Sbjct: 149 ---------------IIVRYDGYHGSTALTAACTGRTGNW----PNFDIAQDRISFLSSP 189 Query: 255 LEEFVKENQQEE--ARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKL 312 QE ++E ED I T+A + EPI + GG + + Sbjct: 190 NPRHAGNRSQEAFLDDLVQEFEDRIESL--GPDTIAAFLAEPILASGGVIIPPAGYHARF 247 Query: 313 RDISRKHGCAFLVDEVQTGGGSTGKFWAHEH-WGLDDPADVMTFSKKMMT-----GGFFH 366 + I KH ++ DEV TG G G+++A E +G+ D++TF+K + + GG Sbjct: 248 KAICEKHDILYISDEVVTGFGRCGEWFASEKVFGV--VPDIITFAKGVTSGYVPLGGLAI 305 Query: 367 KEEFRPNAPYR--------IFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTG 418 E T+ P I +++RE ++ A Sbjct: 306 SEAVLARISGENAKGSWFTNGYTYSNQPVACAAALANIELMEREGIVDQAREMADYFAAA 365 Query: 419 LLDLQARYPQFISRVRGRGTFCSFD-----------TPDESIRNKLISIARNKGVMLGGC 467 L L R ++ R G D++ K+ G+++ Sbjct: 366 LASL--RDLPGVAETRSVGLVGCVQCLLDPTRADGTAEDKAFTLKIDERCFELGLIVRPL 423 Query: 468 GDKSIRFRPTLVFRDHHAHLFLNIFSDILADF 499 GD + P L+ + I + + Sbjct: 424 GDLCV-ISPPLIISRAQIDEMVAIMRQAITEV 454 >4PPM-A nrPDB Length = 861 Score = 304 bits (778), Expect = 6e-83, Method: Composition-based stats. Identities = 93/436 (21%), Positives = 160/436 (36%), Gaps = 71/436 (16%) Query: 76 NYEESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGILP 135 + + G L D G LD+ + + +G++ +V ++ N + + Sbjct: 418 VFRSAAGTQLYDDAGEAFLDMVAGYGCLNLGHNPQPVVNALK---NYLDAQGPNFIQYIS 474 Query: 136 PENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELE 195 KL E L +AP M ++ G+ + E A K Sbjct: 475 IPEQTAKLAEVLCRLAPGNMGRVFFSNSGTEAVEAAMKIA-------------------- 514 Query: 196 TCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPI-APFPRLKYP 254 + G P + L ++HG+T+G L+ T + P D + PF L Sbjct: 515 ----KASTGKPGIAYL--RNSYHGKTLGALSITGRDKHRRYFTPLLDAMVEVPFGDLAAL 568 Query: 255 LEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRD 314 E + + V +++EPIQ EGG + + + ++ Sbjct: 569 REALNR------------------------EDVGALMIEPIQGEGGVHIPPAGYLQAVQQ 604 Query: 315 ISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGFFHKEEF---- 370 + R+ G +VDEVQTG G TGK +A E G++ DV+ SK + G Sbjct: 605 LCRETGVLLMVDEVQTGLGRTGKLFACEWDGIE--PDVLMLSKSLSGGLIPIGATLCRAD 662 Query: 371 -------RPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDLQ 423 + +T+ G +++ + I +DL+ +A G L ++ Sbjct: 663 LWQKAYGTADRFLVHSSTYGGGNLASVVALSALREILAQDLVGHAERMGAYFKQALSEIA 722 Query: 424 ARYPQFISRVRGRGTFCSFDTPDESIRNKLISIARNKGVMLGGCGDKSIRFRPTLVFRDH 483 ARYP F+S VRGRG D++ + + AR L G + +F P V Sbjct: 723 ARYP-FVSEVRGRGLMLGIQF-DQAFTGAVNASAREFATRLPGDWHTTWKFLPDPV--QA 778 Query: 484 HAHLFLNIFSDILADF 499 H ++ L + Sbjct: 779 HLRAAMDRMEQALGEM 794 >6GIO-D nrPDB Length = 439 Score = 297 bits (760), Expect = 8e-81, Method: Composition-based stats. Identities = 101/458 (22%), Positives = 164/458 (35%), Gaps = 62/458 (13%) Query: 60 KQLNIIQNAEAVHF-FCNYEESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQ 118 + +I + F + +GN L++ G +LDL +GY HPA+V+ V++ Sbjct: 10 RDARVIAEIGRLRFSPLSLIGGKGNRLIEEGGRSILDLSGSAGPAALGYGHPAIVEAVEK 69 Query: 119 PQNVSTFINRPALGILPPENFVEKLRESLLSVAPK-GMSQLITMACGSCSNENAFKTIFM 177 A +L P L E LL + P G ++ GS +N+ A + + Sbjct: 70 SVR----DMAGASLLLYPNEAAVSLAEDLLRITPGNGERRVWFGHSGSDANDCAVRVL-- 123 Query: 178 WYRSKERGQSAFSKEELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTH-SKAIHKI 236 I+SF+G++HG G + + + H + Sbjct: 124 ------------------------TAATKRSRIISFIGSYHGNLTGSMGISGHTAMTHTL 159 Query: 237 DIPSFDWPIAPFPRLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQ 296 P + P+P P + A + E+ D + VA + +EPI Sbjct: 160 PRP--GVLLLPYPDPFRP---------RFSAEAVLELLDYHFATSCPPEQVAAVFIEPIL 208 Query: 297 SEGGDNHASDDFFRKLRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTF- 355 S+GG F L+D RKHG +VDEV+ G G TG +H GL+ D++ F Sbjct: 209 SDGGLVVPPPAFLEALQDRCRKHGILVVVDEVKVGLGRTGLMHCFQHEGLE--PDMVVFG 266 Query: 356 ---SKKMMTGGFFHKEEFRPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAG 412 + + +AP + T G+P V+N I+R+ L + G Sbjct: 267 KGLGGGLPLSAVVGPQWVMDHAPAFVLQTTAGNPVATAAGRAVLNTIERQGLAQRSERVG 326 Query: 413 KVLLTGLLDLQARYPQFISRVRGRGTFCSFDTPDES---------IRNKLISIARNKG-- 461 + L L ++ I VRGRG D + K+I G Sbjct: 327 GIFADRLRRLSDKHS-IIGDVRGRGLAIGVDLVSDRGSREPAPVTTTAKIIYRGYQLGAA 385 Query: 462 VMLGGCGDKSIRFRPTLVFRDHHAHLFLNIFSDILADF 499 G + F P L + +I + D Sbjct: 386 FTYVGLNANVLEFMPPLTLTEPEIDEAADIVDQAIGDV 423 >2ZUK-A nrPDB Length = 439 Score = 295 bits (755), Expect = 3e-80, Method: Composition-based stats. Identities = 105/456 (23%), Positives = 168/456 (36%), Gaps = 57/456 (12%) Query: 60 KQLNIIQNAEAVHFFC-NYEESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQ 118 + I N + + FF RG L++ +G ++DL + +GY HPA+V V Sbjct: 11 RDGAAIGNLQKLRFFPLAISGGRGARLIEENGRELIDLSGAWGAASLGYGHPAIVAAVSA 70 Query: 119 PQNVSTFINRPALGILPPENFVEKLRESLLSVAPK-GMSQLITMACGSCSNENAFKTIFM 177 + P L E LL+ P G ++ GS +NE A++ I Sbjct: 71 AAANPAGATILSASNAP----AVTLAERLLASFPGEGTHKIWFGHSGSDANEAAYRAIVK 126 Query: 178 WYRSKERGQSAFSKEELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKID 237 +++F GA+HG T+G +A + ++ Sbjct: 127 ATGRSG--------------------------VIAFAGAYHGCTVGSMAFSG-HSVQADA 159 Query: 238 IPSFDWPIAPFPRLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQS 297 + + P+P P + + +A E L ++ +EPIQS Sbjct: 160 AKADGLILLPYPDPYRPY----RNDPTGDAILTLLTEKLAAV---PAGSIGAAFIEPIQS 212 Query: 298 EGGDNHASDDFFRKLRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADV----M 353 +GG D F RK DI R HG + DEV+ G +G+ EH G D+ Sbjct: 213 DGGLIVPPDGFLRKFADICRAHGILVVCDEVKVGLARSGRLHCFEHEGF--VPDILVLGK 270 Query: 354 TFSKKMMTGGFFHKEEFRPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGK 413 + E A T G+P V+ I R+DL + A G+ Sbjct: 271 GLGGGLPLSAVIAPAEILDCASAFAMQTLHGNPISAAAGLAVLETIDRDDLPAMAERKGR 330 Query: 414 VLLTGLLDLQARYPQFISRVRGRGTFCSFDT--------PDESIRNKLISIARNKGVML- 464 +L GL +L R+P I +RGRG C + P + KLI A G+++ Sbjct: 331 LLRDGLSELAKRHP-LIGDIRGRGLACGMELVCDRQSREPARAETAKLIYRAYQLGLVVY 389 Query: 465 -GGCGDKSIRFRPTLVFRDHHAHLFLNIFSDILADF 499 G + F P L + H L++ ++ Sbjct: 390 YVGMNGNVLEFTPPLTITETDIHKALDLLDRAFSEL 425 >5G4J-A nrPDB Length = 446 Score = 291 bits (744), Expect = 5e-79, Method: Composition-based stats. Identities = 99/471 (21%), Positives = 167/471 (35%), Gaps = 61/471 (12%) Query: 48 TEVPGPRSRELMKQLNIIQNAEAV--HFFCNYEESRGNYLVDVDGNRMLDLYSQISSIPI 105 + VP + L ++ I + G +L D G LD Y+ + + Sbjct: 10 SRVPQTANDLLARRYATIGPHSPLFYRQPLELVSGSGVWLTDAQGKVYLDGYNNVPHV-- 67 Query: 106 GYSHPALVKLVQQPQNVSTFINRPALGILPPENFVEKLRESLLSVAPKGMSQLITMACGS 165 G+++PA+ + Q R + V + E+LLS + +L GS Sbjct: 68 GHANPAVADAIYQQLLTVNLHTR------YLNSRVVEYAEALLSKFDGALERLFLTNSGS 121 Query: 166 CSNENAFKTIFMWYRSKERGQSAFSKEELETCMINQAPGCPDYSILSFMGAFHGRTMGCL 225 +NE A + + S FS T + G + L G + L Sbjct: 122 EANELALRIARQHTGNTGVLVSDFSYHGNTTSLAEITTGLTVHEPL-------GAHVRAL 174 Query: 226 ATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKK 285 I ++D+P + L +V+ I + Sbjct: 175 RIPDVSGIAEVDVPVL------------------------LEQSLADVDAAIASLQAAGH 210 Query: 286 TVAGIIVEPIQSEGGDNHASDDFFRKLRDISRKHGCAFLVDEVQTGGGSTGK-FWAHEHW 344 V+ + +P+ S G + + R G + DEVQ+G G TG W ++ + Sbjct: 211 GVSVFLFDPLFSTEGLLQLPSGYIEGVATRVRAAGGLVISDEVQSGFGRTGSGMWGYQMF 270 Query: 345 GLDDPADVMTFSKKMMTGGFFHKEEFRPN------APYRIFNTWLGDPSKNLLLAEVINI 398 ++ +++T K M G FNT+ G+P + V+ Sbjct: 271 NVE--PELVTMGKPMGNGHPIGAVVTTAELLDEFGRHNMFFNTFAGNPVSSAAGLAVLRY 328 Query: 399 IKREDLLSNAAHAGKVLLTGLLDLQARYPQFISRVRGRGTFCSFDT--------PDESIR 450 + +EDL++ A GK + L ++ R + VRGRG F D P ++ Sbjct: 329 MDQEDLMAKADQLGKYIRKRLENIAQRSGN-VGSVRGRGLFFGIDIIESDGSRNPAPALT 387 Query: 451 NKLISIARNKGVMLGGCG--DKSIRFRPTLVFRDHHAHLFLNIFSDILADF 499 LI R +GV++ G D ++ RP LVF HA + L LA Sbjct: 388 KILIEDMRERGVLISRVGPHDNVLKMRPPLVFGREHADILLGQLELSLASL 438 >6ERK-A nrPDB Length = 451 Score = 290 bits (742), Expect = 1e-78, Method: Composition-based stats. Identities = 84/440 (19%), Positives = 149/440 (33%), Gaps = 56/440 (12%) Query: 75 CNYEESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGIL 134 + + G Y+V DG R++D S + GY+HP L + + + L Sbjct: 48 IVIDRAEGIYIVTEDGTRLIDGMSSWWASVHGYNHPKLNAAMIEQLGKMAHVMFGGLTHQ 107 Query: 135 PPENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEEL 194 P L + LLS+ P G+ + GS + E A K + + +R Sbjct: 108 P----AIDLGKKLLSIVPAGLDAIFYADSGSIAVEVALKMALQYQIAAKRPSKC------ 157 Query: 195 ETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHS-KAIHKIDIPSFDWPIAPFPRLKY 253 S ++G T ++ +H + Sbjct: 158 --------------QFASTHSGYYGDTWHAMSVCDPINGMHSLYGKQL------------ 191 Query: 254 PLEEFVKENQQEEARCL--EEVEDLIVKYRKKKKTVAGIIVEPI-QSEGGDNHASDDFFR 310 P++ FV R L E E L + K +AG I+EPI Q GG S + + Sbjct: 192 PMQHFVAAPPMGFERDLTQSEREALTEFFVKNSDKLAGFIIEPIIQGAGGMRFYSPQYLQ 251 Query: 311 KLRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGFFHKEEF 370 LR + ++ + DE+ TG G +GK +A EH + D+MT K + G Sbjct: 252 LLRKLCDEYDVLLIADEIATGFGRSGKLFACEHAAIS--PDIMTIGKALTGGYMTFAATL 309 Query: 371 RPNAPYR-----------IFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGL 419 T++G+P + I++I D+ + + ++ L Sbjct: 310 STREIADTISQSDYPALMHGPTFMGNPLACAVACASIDLIVSYDIEARTENMQAIMNEQL 369 Query: 420 LDLQARYPQFISRVRGRGTFCSFDTPDESIRNKLISIARNKGVMLGGCGDKSIRFRPTLV 479 + + VR G + + ++ N G+ + G K + P V Sbjct: 370 APAVSLEG--VKEVRCLGAVAVIELNEAVDMPIFQTLLINNGIWVRPFG-KLVYIMPPYV 426 Query: 480 FRDHHAHLFLNIFSDILADF 499 D +++ + Sbjct: 427 ITDDELTTLCQALLKVVSSY 446 >5UC7-A nrPDB Length = 431 Score = 290 bits (742), Expect = 1e-78, Method: Composition-based stats. Identities = 80/435 (18%), Positives = 154/435 (35%), Gaps = 53/435 (12%) Query: 77 YEESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGILPP 136 E + G L+ G R++D S + GY+HP L ++ + + + + P Sbjct: 31 VERAEGCELILSGGERLVDGMSSWWAAIHGYNHPQLNAAMKTQIDAMSHVMFGGITHAP- 89 Query: 137 ENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELET 196 +L L+++ P + + GS + E A K ++++K + F Sbjct: 90 ---AIELCRKLVAMTPAPLECVFLADSGSVAVEVAMKMALQYWQAKGESRQRF------- 139 Query: 197 CMINQAPGCPDYSILSFMGAFHGRTMGCLATTHS-KAIHKIDIPSFDWPIAPFPRLKYPL 255 L+F +HG T G ++ ++H + W L P Sbjct: 140 --------------LTFRNGYHGDTFGAMSVCDPHNSMHSL------WKGYLAENLFAPA 179 Query: 256 EEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPI-QSEGGDNHASDDFFRKLRD 314 + + +E R + L+ +R +A +I+EPI Q GG + +++R Sbjct: 180 PQSRMGGEWDE-RDMVAFARLMAAHR---HEIAAVILEPIVQGAGGMRIYHPQWLQRIRQ 235 Query: 315 ISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGFFHKEEF---- 370 + + G + DE+ TG G TG+ +A EH G+ D++ K + G Sbjct: 236 MCDREGILLIADEIATGFGRTGRLFACEHAGI--APDILCLGKALTGGTMTLSATLTSRQ 293 Query: 371 -------RPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDLQ 423 + T++G+P + + +++ D A L L Sbjct: 294 VAETISNGEAGCFMHGPTFMGNPLACAVANASLTLLESGDWRRQVAAIEAQLREEL--AP 351 Query: 424 ARYPQFISRVRGRGTFCSFDTPDESIRNKLISIARNKGVMLGGCGDKSIRFRPTLVFRDH 483 A ++ VR G +T L +GV + G K I P + + Sbjct: 352 AADSPQVADVRVLGAIGVVETTRPVNIAALQQFFVRQGVWVRPFG-KLIYLMPPYIIQPE 410 Query: 484 HAHLFLNIFSDILAD 498 ++ + + Sbjct: 411 QLRRLTQAVNEAVRE 425 >3A8U-X nrPDB Length = 449 Score = 285 bits (728), Expect = 4e-77, Method: Composition-based stats. Identities = 70/439 (15%), Positives = 149/439 (33%), Gaps = 49/439 (11%) Query: 80 SRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGILPPENF 139 + G++LVD G ++ D S + + G++ + + V + +ST P P +F Sbjct: 39 AEGSWLVDDKGRKVYDSLSGLWTCGAGHTRKEIQEAVAKQ--LSTLDYSPGFQYGHPLSF 96 Query: 140 VEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELETCMI 199 +L E + + P ++ + GS A K + ++R K + Sbjct: 97 --QLAEKITDLTPGNLNHVFFTDSGSECALTAVKMVRAYWRLKGQA-------------- 140 Query: 200 NQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFV 259 ++ +HG + + K+ + P + Sbjct: 141 ------TKTKMIGRARGYHGVNIAGTSLGGVNGNRKLFGQPMQD-VDHLPHTLLASNAYS 193 Query: 260 KENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDISRKH 319 + +E L + E L + +A + VEP+ G + + ++ R+I +H Sbjct: 194 RGMPKEGGIALAD-ELLKLIELHDASNIAAVFVEPLAGSAGVLVPPEGYLKRNREICNQH 252 Query: 320 GCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGFFHKEEFRPNAPYR-- 377 + DEV TG G TG + + +G+ D+M +K++ G Y+ Sbjct: 253 NILLVFDEVITGFGRTGSMFGADSFGVT--PDLMCIAKQVTNGAIPMGAVIASTEIYQTF 310 Query: 378 -------------IFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDLQA 424 T+ P + ++++E+L+ + A L ++ Sbjct: 311 MNQPTPEYAVEFPHGYTYSAHPVACAAGLAALCLLQKENLVQSVAEVAPHFEKALHGIKG 370 Query: 425 RYPQFISRVRGRGTFCSFDTP----DESIRNKLISIARNKGVMLGGCGDKSIRFRPTLVF 480 + + +R G + D +R +A K G +++F PT Sbjct: 371 A--KNVIDIRNFGLAGAIQIAPRDGDAIVRPFEAGMALWKAGFYVRFGGDTLQFGPTFNS 428 Query: 481 RDHHAHLFLNIFSDILADF 499 + + ++L Sbjct: 429 KPQDLDRLFDAVGEVLNKL 447 >1S09-A nrPDB Length = 429 Score = 282 bits (722), Expect = 2e-76, Method: Composition-based stats. Identities = 86/444 (19%), Positives = 155/444 (34%), Gaps = 60/444 (13%) Query: 72 HFFCN-YEESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPA 130 + G L+ DG R++D S + GY+HP L ++ + + + Sbjct: 23 PLPVYPVVSAEGCELILSDGRRLVDGMSSWWAAIHGYNHPQLNAAMKSQIDAMSHVMFGG 82 Query: 131 LGILPPENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFS 190 + P +L L+++ P+ + + GS + E A K ++++K + F Sbjct: 83 ITHAP----AIELCRKLVAMTPQPLECVFLADSGSVAVEVAMKMALQYWQAKGEARQRF- 137 Query: 191 KEELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTH----SKAIHKIDIPSFDWPIA 246 L+F FHG T G ++ ++ K +P + A Sbjct: 138 --------------------LTFRNGFHGDTFGAMSVCDPDNSMHSLWKGYLPENLFAPA 177 Query: 247 PFPRLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPI-QSEGGDNHAS 305 P R+ +E R + L+ +R +A +I+EPI Q GG Sbjct: 178 PQSRMDGEWDE----------RDMVGFARLMAAHR---HEIAAVIIEPIVQGAGGMRMYH 224 Query: 306 DDFFRKLRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGFF 365 ++ +++R I + G + DE+ TG G TGK +A EH + D++ K + G Sbjct: 225 PEWLKRIRKICDREGILLIADEIATGFGRTGKLFACEH--AEIAPDILCLGKALTGGTMT 282 Query: 366 HKEEF-----------RPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKV 414 + T++G+P + I++ D A Sbjct: 283 LSATLTTREVAETISNGEAGCFMHGPTFMGNPLACAAANASLAILESGDWQQQVADIEVQ 342 Query: 415 LLTGLLDLQARYPQFISRVRGRGTFCSFDTPDESIRNKLISIARNKGVMLGGCGDKSIRF 474 L L AR + ++ VR G +T L +GV + G K I Sbjct: 343 LREQL--APARDAEMVADVRVLGAIGVVETTHPVNMAALQKFFVEQGVWIRPFG-KLIYL 399 Query: 475 RPTLVFRDHHAHLFLNIFSDILAD 498 P + + + D Sbjct: 400 MPPYIILPQQLQRLTAAVNRAVQD 423 >5G0A-A nrPDB Length = 483 Score = 275 bits (703), Expect = 3e-74, Method: Composition-based stats. Identities = 74/471 (15%), Positives = 168/471 (35%), Gaps = 84/471 (17%) Query: 74 FCNYEESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGI 133 E + G+YL+ DG R+LD ++Q+ + +G + + +++ + + Sbjct: 33 PVPIESTEGDYLIMPDGTRLLDFFNQLYCVNLGQKNQKVNAAIKEALDR-----YGFVWD 87 Query: 134 LPPENFVEKLRESLLSVAPKGMS---QLITMACGSCSNENAFKTIFMWYRSKERGQSAFS 190 ++ K + ++ ++ ++ GS + E A ++ Sbjct: 88 TYATDYKAKAAKIIIEDILGDEDWPGKVRFVSTGSEAVETALNIARLYTN---------- 137 Query: 191 KEELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSF--------- 241 +++ +HG T G T ++ + Sbjct: 138 ----------------RPLVVTREHDYHGWTGGAATVTRLRSYRSGLVGENSESFSAQIP 181 Query: 242 ------DWPIAPFPRLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPI 295 +AP P + + + +++ E ++ +I Y + VA +I E Sbjct: 182 GSSYNSAVLMAPSPNMFQDSDGNLLKDENGELLSVKYTRRMIENY--GPEQVAAVITEVS 239 Query: 296 QSEGGDNHASDDFFRKLRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTF 355 Q G ++ ++R ++++ G ++ DEV TG G TGK++ ++H+G+ D++T Sbjct: 240 QG-AGSAMPPYEYIPQIRKMTKELGVLWINDEVLTGFGRTGKWFGYQHYGVQ--PDIITM 296 Query: 356 SKKMMT-----GGFFHKEE---FRPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLSN 407 K + + G +E F + +T+ G P + + ++ E+ + Sbjct: 297 GKGLSSSSLPAGAVLVSKEIAAFMDKHRWESVSTYAGHPVAMAAVCANLEVMMEENFVEQ 356 Query: 408 AAHAGKVLLTGLLDLQARYPQFISRVRGRGTFCSFDTPDESIRNKLI------------- 454 A +G+ + + L LQ ++ + I G G D + + + Sbjct: 357 AKDSGEYIRSKLELLQEKH-KSIGNFDGYGLLWIVDIVNAKTKTPYVKLDRNFTHGMNPN 415 Query: 455 --------SIARNKGVMLGGCGDKSIRFRPTLVFRDHHAHLFLNIFSDILA 497 A KGV++GG ++R +L ++ L Sbjct: 416 QIPTQIIMKKALEKGVLIGGVMPNTMRIGASLNVSRGDIDKAMDALDYALD 466 >3I4J-A nrPDB Length = 430 Score = 253 bits (647), Expect = 1e-67, Method: Composition-based stats. Identities = 84/440 (19%), Positives = 149/440 (33%), Gaps = 63/440 (14%) Query: 74 FCNYEESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGI 133 + G +L D G R LD S IG+ + + + F++ Sbjct: 12 YPVAVRGEGVFLYDDAGRRYLDGSSGALVANIGHGRAEVGERMAAQAARLPFVHGSQFSS 71 Query: 134 LPPENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEE 193 E + +L + + ++ GS + E+A K ++ + Sbjct: 72 DVLEEYAGRLARFVGLPT----FRFWAVSGGSEATESAVKLARQYHVERGEP-------- 119 Query: 194 LETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKY 253 + +++ + ++HG ++G LA + A ++ P +P+L Sbjct: 120 ------------GRFKVITRVPSYHGASLGSLAASGMGARRELYTPLMRPEA--WPKLPK 165 Query: 254 PLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEG-GDNHASDDFFRKL 312 P E R L E R+ +TVA + EP+ + ++ ++ Sbjct: 166 PDPARNGAEDAEGLRALLE--------REGPETVAAFMAEPVVGASDAALAPAPGYYERV 217 Query: 313 RDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGFFHK----- 367 RDI + G F+ DEV +G G G A W D+ K + G Sbjct: 218 RDICDEAGIIFIADEVMSGMGRCGSPLALSRWSG-VTPDIAVLGKGLAAGYAPLAGLLAA 276 Query: 368 -----EEFRPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDL 422 + + T+ G P V++I++REDL A G LL GL L Sbjct: 277 PQVYETVMGGSGAFMHGFTYAGHPVSVAAGLSVLDIVEREDLTGAAKERGAQLLAGLQAL 336 Query: 423 QARYPQFISRVRGRG---------TFCSFDTPDESIRNKLISIARNKGVMLGG------- 466 QAR+PQ + +VRG G I +++ + A +G++ Sbjct: 337 QARFPQMM-QVRGTGLLLGVVLGDLATGQAFETPGIASRIGAAALKRGLITYPGSGAEPN 395 Query: 467 CGDKSIRFRPTLVFRDHHAH 486 + P L Sbjct: 396 GRGDHLLLGPPLSITAAEVD 415 >3L44-A nrPDB Length = 434 Score = 253 bits (646), Expect = 1e-67, Method: Composition-based stats. Identities = 71/389 (18%), Positives = 120/389 (30%), Gaps = 63/389 (16%) Query: 68 AEAVHFFCNYEESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFIN 127 A E +G Y DVDGN+ +D + I G++HP + K + Sbjct: 32 AVGGGAPIAMERGKGAYFWDVDGNKYIDYLAAYGPIITGHAHPHITKAITTAAENGVLYG 91 Query: 128 RPALGILPPENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQS 187 P K + L P + ++ + G+ + + + Sbjct: 92 TPT-------ALEVKFAKMLKEAMPA-LDKVRFVNSGTEAVMTTIRVARAYTGRT----- 138 Query: 188 AFSKEELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAP 247 I+ F G +HG + L S Sbjct: 139 ---------------------KIMKFAGCYHGHSDLVLVAAGSGP--------------- 162 Query: 248 FPRLKYPLEEFVKENQQEEARCL--EEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHAS 305 L P V ++ +E + VE L K VA I+VEPI G Sbjct: 163 -STLGTPDSAGVPQSIAQEVITVPFNNVETLKEALDKWGHEVAAILVEPIVGNFGIVEPK 221 Query: 306 DDFFRKLRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGFF 365 F K+ ++ + G + DEV T + L D+ K + G Sbjct: 222 PGFLEKVNELVHEAGALVIYDEVITAF---RFMYGGAQDLLGVTPDLTALGKVIGGGLPI 278 Query: 366 HK--------EEFRPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLT 417 E+ P P T G+P+ + ++++E L G L Sbjct: 279 GAYGGKKEIMEQVAPLGPAYQAGTMAGNPASMASGIACLEVLQQEGLYEKLDELGATLEK 338 Query: 418 GLLDLQARYPQFISRVRGRGTFCSFDTPD 446 G+L+ A++ I+ R +G + T + Sbjct: 339 GILEQAAKHNIDITLNRLKGALTVYFTTN 367 >2CFB-A nrPDB Length = 411 Score = 250 bits (637), Expect = 1e-66, Method: Composition-based stats. Identities = 77/444 (17%), Positives = 144/444 (32%), Gaps = 69/444 (15%) Query: 74 FCNYEESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGI 133 ++ +G ++ DVDGN+ +D +G++HP ++ + T P L Sbjct: 19 PIVFDHVKGAHIWDVDGNQYIDYVGSWGPAIVGHAHPEVIDALHAALEKGTSFGAPCL-- 76 Query: 134 LPPENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEE 193 L E +++ P + + + G+ + + + + + Sbjct: 77 -----LENILAEMVIAAVPS-VEMVRFVNSGTEACMAVLRLMRAYTQ------------- 117 Query: 194 LETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKY 253 ++ F G +HG L S + + +P D P P Sbjct: 118 -------------REKVIKFEGCYHGHADMFLVKAGS-GVATLGLP--DSPGVP------ 155 Query: 254 PLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLR 313 + LE V L +Y +AG+I+EP+ G F LR Sbjct: 156 --KATTAATLTAPYNDLEAVSRLFEQY---PNDIAGVILEPVVGNAGFIPPDAGFLEGLR 210 Query: 314 DISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSK----KMMTGGFFHKEE 369 ++++++G + DEV TG A E +G+ D+ T K + G + + E Sbjct: 211 ELTKQYGALLVFDEVMTGF-RIAYGGAQEKFGVT--PDLTTLGKVIGGGLPVGAYGGRAE 267 Query: 370 ----FRPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDLQAR 425 P P T G+P + + I+ R + L+ GLLD Sbjct: 268 IMKMVAPAGPVYQAGTLSGNPLAMTAGIKTLEILSRPGSYEHLDRITGKLVQGLLDAARE 327 Query: 426 YPQFISRVRGRGTFCSFDTPDESIRNKLI--SIARNKGVMLGGCGDKSIRFRP------- 476 + + G F F T + S + G ++ I P Sbjct: 328 FGHEVCGGHISGMFGLFFTAGPVTNYEQAKQSDLKKFAAFHRGMLEQGIYLAPSQFEAGF 387 Query: 477 -TLVFRDHHAHLFLNIFSDILADF 499 +L + + +L+ Sbjct: 388 TSLAHTEADIERTIAAARTVLSQL 411 >5DDW-A nrPDB Length = 523 Score = 245 bits (624), Expect = 4e-65, Method: Composition-based stats. Identities = 88/496 (17%), Positives = 171/496 (34%), Gaps = 70/496 (14%) Query: 71 VHFFCNYEESRGNYLV--DVDGNRM--LDLYSQISSIPIGYSHPALVKLVQQPQNVSTFI 126 + Y + GN + D +G + LD S+ G++HP ++ + + T + Sbjct: 22 MGLGVEYVRAEGNTVYYLDDEGREVPVLDHACGFGSLIFGHNHPEIIAHAKAALDAGTVV 81 Query: 127 NRPALGILPPENFVEKLRESLLSVAPKGMSQ--LITMACGSCSNENAFKTIFMWYRSKER 184 + L P N + ++ ++ + I G+ +NE K + + + Sbjct: 82 HA-QLSRQPRANQISRILNDIMRRETGRDDRYNAIFANSGAEANEICMKHAELERQERIT 140 Query: 185 GQSAFSKEELETCMINQAPGCPDYS----------------------------------I 210 A EL+T G Sbjct: 141 ALFAEIDAELDTAREALTTGTATLDTASLPLVGGGAGDVDGVIADIHRHNDERRAERPLF 200 Query: 211 LSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFVKENQQEEARCL 270 L+ G+FHG+ +G + T ++ + + P P + L + E+++ L Sbjct: 201 LTLDGSFHGKLVGSIQLTQNEP-WRTPFTALSSPARFLPADEPELIGKIVEDERRSVLTL 259 Query: 271 EEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDISRKHGCAFLVDEVQT 330 +D + + VA I VEP++ G + + +L + GC +VDEVQT Sbjct: 260 SLDKDTVRVVERDFPVVAAIFVEPVRGGSGMKTVTPELAEELHRLRDTLGCPLVVDEVQT 319 Query: 331 GGGSTGKFWAHEHWGLDDPADVMTFSKKMMTG------GFFHKEEFRPNAPYRIFNTWLG 384 G G TG F+ G+ D T +K + G ++ F P +T+ Sbjct: 320 GIGRTGAFFGSALLGIR--GDYYTLAKAIGGGIVKNSVALIRQDRFLPAMEVIHSSTFAK 377 Query: 385 DPSKNLLLAEVINIIKRED--LLSNAAHAGKVLLTGLLDLQARYPQFISRVRGRGTFCSF 442 D + +V+ +++ + + G+ L L ++A + +S V G G + Sbjct: 378 DGLSASIALKVLEMVEADGGRVYQRVRERGQRLEAMLESVRADHSDVVSAVWGTGLMLAL 437 Query: 443 DTPDES-IRNKLISIARNKGVM---------------LGGCGDKS--IRFRPTLVFRDHH 484 + D+S ++ I G + + G +S +RF P+L D Sbjct: 438 ELRDQSNATSQAIREKAAHGFLGYVLAGFLLREHHIRVLPAGPRSGFLRFSPSLYITDEE 497 Query: 485 AHLFLNIFSDILADFK 500 + + Sbjct: 498 IDRTETALRSLFTALR 513 >4E77-A nrPDB Length = 429 Score = 242 bits (618), Expect = 2e-64, Method: Composition-based stats. Identities = 76/410 (18%), Positives = 127/410 (30%), Gaps = 70/410 (17%) Query: 50 VPGPRSRELMKQLNIIQNAEAVHFFCNYEESRGNYLVDVDGNRMLDLYSQISSIPIGYSH 109 +PG + + + F E + G YL DVDG +D + +G++H Sbjct: 18 IPG----GVNSPVRAFTGVGGIPLF--IERADGAYLFDVDGKAYIDYVGSWGPMILGHNH 71 Query: 110 PALVKLVQQPQNVSTFINRPALGILPPENFVEKLRESLLSVAPKGMSQLITMACGSCSNE 169 PA+ + V + L P K+ + + + P M + + G+ + Sbjct: 72 PAIRQAVIEAVER-------GLSFGAPTEMEVKMAQLVTDLVPT-MDMVRMVNSGTEATM 123 Query: 170 NAFKTIFMWYRSKERGQSAFSKEELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTH 229 +A + + I+ F G +HG L Sbjct: 124 SAIRLARGYTG--------------------------RDKIIKFEGCYHGHADCLLVKAG 157 Query: 230 SKAIHKIDIPSFDWPIAPFPRLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAG 289 S A+ + P+ P P +F K L V +Y + VA Sbjct: 158 SGAL-TLGQPN--SPGVP--------TDFAKHTLTCTYNDLASVRQAFEQY---PQEVAC 203 Query: 290 IIVEPIQSEGGDNHASDDFFRKLRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDP 349 IIVEP+ +F LR + + G ++DEV TG A +++ + Sbjct: 204 IIVEPVAGNMNCIPPLPEFLPGLRALCDEFGALLIIDEVMTGF-RVALAGAQDYYHV--I 260 Query: 350 ADVMTFSK----KMMTGGFFHKEEF----RPNAPYRIFNTWLGDPSKNLLLAEVINIIKR 401 D+ K M G F + E P P T G+P + I + Sbjct: 261 PDLTCLGKIIGGGMPVGAFGGRREVMNALAPTGPVYQAGTLSGNPIAMAAGFACLTEISQ 320 Query: 402 EDLLSNAAHAGKVLLTGLLDLQARY--PQFISRVRGRGTFCSFDTPDESI 449 + L TGL P ++ V G + Sbjct: 321 VGVYETLTELTDSLATGLRHAAKEENIPLVVNHV---GGMFGLFFTNADT 367 >4GSA-A nrPDB Length = 432 Score = 239 bits (610), Expect = 2e-63, Method: Composition-based stats. Identities = 69/390 (17%), Positives = 122/390 (31%), Gaps = 66/390 (16%) Query: 74 FCNYEESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGI 133 ++ + Y DVDGNR +D G++HP +++ ++ T P Sbjct: 40 PIVFDRVKDAYAWDVDGNRYIDYVGTWGPAICGHAHPEVIEALKVAMEKGTSFGAPC--- 96 Query: 134 LPPENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEE 193 L E + P + + + G+ + + + + Sbjct: 97 ----ALENVLAEMVNDAVPS-IEMVRFVNSGTEACMAVLRLMRAYTG------------- 138 Query: 194 LETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAP-FPRLK 252 I+ F G +HG L S + + P +P P+ Sbjct: 139 -------------RDKIIKFEGCYHGHADMFLVKAGS------GVATLGLPSSPGVPKKT 179 Query: 253 YPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKL 312 N E + L + + +AG+I+EPI G F L Sbjct: 180 TANTLTTPYNDLEAVKAL---------FAENPGEIAGVILEPIVGNSGFIVPDAGFLEGL 230 Query: 313 RDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSK----KMMTGGFFHKE 368 R+I+ +H + DEV TG E +G+ D+ T K + G + K Sbjct: 231 REITLEHDALLVFDEVMTGF-RIAYGGVQEKFGVT--PDLTTLGKIIGGGLPVGAYGGKR 287 Query: 369 E----FRPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDLQA 424 E P P T G+P + + ++++ K L GLL + Sbjct: 288 EIMQLVAPAGPMYQAGTLSGNPLAMTAGIKTLELLRQPGTYEYLDQITKRLSDGLLAIAQ 347 Query: 425 R--YPQFISRVRGRGTFCSFDTPDESIRNK 452 + +V G F + + N Sbjct: 348 ETGHAACGGQVSG---MFGFFFTEGPVHNY 374 >4WYG-A nrPDB Length = 457 Score = 238 bits (607), Expect = 4e-63, Method: Composition-based stats. Identities = 77/433 (17%), Positives = 138/433 (31%), Gaps = 63/433 (14%) Query: 81 RGNYLVDV-DGN--RMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGILPPE 137 G +L + DG +LD S + G+ HPAL + + V + L P Sbjct: 62 HGAWLTLIRDGQPIEVLDAMSSWWTAIHGHGHPALDQALTTQLRVMNHVMFGGLTHEP-- 119 Query: 138 NFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELETC 197 +L + L+ + P G+ + GS S E A K ++R + Sbjct: 120 --AARLAKLLVDITPAGLDTVFFSDSGSVSVEVAAKMALQYWRGRGLPGKRR-------- 169 Query: 198 MINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHK---IDIPSFDWPIAPFPRLKYP 254 ++++ G +HG T ++ D+ + PR P Sbjct: 170 ------------LMTWRGGYHGDTFLAMSICDPHGGMHSLWTDVLAAQVFAPQVPRDYDP 217 Query: 255 LEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPI-QSEGGDNHASDDFFRKLR 313 E + + +A ++VEP+ Q GG + LR Sbjct: 218 AYSAAFE----------------AQLAQHAGELAAVVVEPVVQGAGGMRFHDPRYLHDLR 261 Query: 314 DISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGFFHKEEF--- 370 DI R++ + DE+ TG G TG +A +H G+ D+M K + G Sbjct: 262 DICRRYEVLLIFDEIATGFGRTGALFAADHAGVS--PDIMCVGKALTGGYLSLAATLCTA 319 Query: 371 --------RPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDL 422 T++ +P + + ++ +D + L GL Sbjct: 320 DVAHTISAGAAGALMHGPTFMANPLACAVSVASVELLLGQDWRTRITELAAGLTAGLDT- 378 Query: 423 QARYPQFISRVRGRGTFCSFDTPDESIRNKLISIARNKGVMLGGCGDKSIRFRPTLVFRD 482 AR ++ VR G + A ++GV L + P + Sbjct: 379 -ARALPAVTDVRVCGAIGVIECDRPVDLAVATPAALDRGVWLRPF-RNLVYAMPPYICTP 436 Query: 483 HHAHLFLNIFSDI 495 + ++ Sbjct: 437 AEITQITSAMVEV 449 >3BS8-A nrPDB Length = 438 Score = 236 bits (602), Expect = 1e-62, Method: Composition-based stats. Identities = 80/446 (17%), Positives = 152/446 (34%), Gaps = 74/446 (16%) Query: 74 FCNYEESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGI 133 E +G+ + D+DGN +D + +G+++ +V+ +++ T P Sbjct: 44 PIFMERGKGSKIFDIDGNEYIDYVLSWGPLILGHTNDRVVESLKKVAEYGTSFGAPT--- 100 Query: 134 LPPENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEE 193 +L + ++ P + + ++ G+ + +A + + Sbjct: 101 ----EVENELAKLVIDRVPS-VEIVRMVSSGTEATMSALRLARGYTGRN----------- 144 Query: 194 LETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKY 253 IL F G +HG L S + + +P D P P Sbjct: 145 ---------------KILKFEGCYHGHGDSLLIKAGS-GVATLGLP--DSPGVP------ 180 Query: 254 PLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLR 313 E K LE V+ + +++ + +AG+IVEP+ G + F + LR Sbjct: 181 --EGIAKNTITVPYNDLESVK---LAFQQFGEDIAGVIVEPVAGNMGVVPPQEGFLQGLR 235 Query: 314 DISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSK----KMMTGGFFHKEE 369 DI+ ++G + DEV TG A ++G+ D+ K + G + K E Sbjct: 236 DITEQYGSLLIFDEVMTGF-RVDYNCAQGYFGVT--PDLTCLGKVIGGGLPVGAYGGKAE 292 Query: 370 ----FRPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDLQAR 425 P+ P T G+P E + + D N G L G+ Sbjct: 293 IMEQIAPSGPIYQAGTLSGNPLAMTAGLETLKQL-TPDSYKNFIKKGDRLEEGISKAAEA 351 Query: 426 YPQFISRVRGRGTFCSFDTPDESIRNKLISIARNKGVML---GGCGDKSIRFRPTLVF-- 480 + + R G+ F +E + N + A + + G ++ + F P F Sbjct: 352 HGIPHTFNRA-GSMIGFFFTNEPVINYETAKASDLKLFASYYKGMANEGV-FLPPSQFEG 409 Query: 481 -------RDHHAHLFLNIFSDILADF 499 D + + A+ Sbjct: 410 LFLSTAHTDEDIENTIQAAEKVFAEI 435 >3K28-A nrPDB Length = 429 Score = 232 bits (592), Expect = 2e-61, Method: Composition-based stats. Identities = 72/396 (18%), Positives = 133/396 (33%), Gaps = 65/396 (16%) Query: 74 FCNYEESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGI 133 E +G+ + D+DGN +D + G+++ +V+ ++ T P Sbjct: 36 PLFMERGKGSKVYDIDGNEYIDYVLSWGPLIHGHANDRVVEALKAVAERGTSFGAPT--- 92 Query: 134 LPPENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEE 193 KL + ++ P + + + G+ + +A + + Sbjct: 93 ----EIENKLAKLVIERVPS-IEIVRMVNSGTEATMSALRLARGYTGRN----------- 136 Query: 194 LETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKY 253 IL F+G +HG L S + + +P D P P Sbjct: 137 ---------------KILKFIGCYHGHGDSLLIKAGS-GVATLGLP--DSPGVP------ 172 Query: 254 PLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLR 313 E K LE V+ ++ +A +IVEP+ G F LR Sbjct: 173 --EGVAKNTITVAYNDLESVKYAFEQF---GDDIACVIVEPVAGNMGVVPPQPGFLEGLR 227 Query: 314 DISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSK----KMMTGGFFHKEE 369 +++ ++G + DEV TG ++G+ D+ K + G + K E Sbjct: 228 EVTEQNGALLIFDEVMTGF-RVAYNCGQGYYGVT--PDLTCLGKVIGGGLPVGAYGGKAE 284 Query: 370 ----FRPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDLQAR 425 P+ P T G+P E + + E + ++L GL + Sbjct: 285 IMRQVAPSGPIYQAGTLSGNPLAMAAGYETLVQLTPESYVE-FERKAEMLEAGLRKAAEK 343 Query: 426 Y--PQFISRVRGRGTFCSFDTPDESIRNKLISIARN 459 + P I+R G+ DE + N + + N Sbjct: 344 HGIPHHINRA---GSMIGIFFTDEPVINYDAAKSSN 376 >5I92-A nrPDB Length = 435 Score = 231 bits (590), Expect = 4e-61, Method: Composition-based stats. Identities = 75/382 (19%), Positives = 131/382 (34%), Gaps = 65/382 (17%) Query: 50 VPGPRSRELMKQLNIIQNAEAVHFFCNYEESRGNYLVDVDGNRMLDLYSQISSIPIGYSH 109 +PG + + ++ F ++ + G Y++D D R +D + +G+SH Sbjct: 23 IPG----GVNSPVRAFKSVGGTPLF--FKHAEGAYVLDEDDKRYVDYVGSWGPMILGHSH 76 Query: 110 PALVKLVQQPQNVSTFINRPALGILPPENFVEKLRESLLSVAPKGMSQLITMACGSCSNE 169 P ++ V++ + L P ++ + + S+ P M + ++ G+ + Sbjct: 77 PDVLDAVRRQLD-------HGLSYGAPTALEVEMADLVCSMVPS-MEMVRMVSSGTEATM 128 Query: 170 NAFKTIFMWYRSKERGQSAFSKEELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTH 229 +A + + SI+ F G +HG + L Sbjct: 129 SAIRLARGYTG--------------------------RDSIIKFEGCYHGHSDSLLVKAG 162 Query: 230 SKAIHKIDIPSFDWPIAPFPRLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAG 289 S A+ +P+ P P K+ L ++E + + K VA Sbjct: 163 SGAL-TFGVPN--SPGVPAAFAKHTLT-----------LPFNDIEAVRKTLGEVGKEVAC 208 Query: 290 IIVEPIQSEGGDNHASDDFFRKLRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDP 349 IIVEP+ + F LR+ +HG + DEV TG A ++G+ Sbjct: 209 IIVEPVAGNMNCVPPAPGFLEGLREACDEHGVVLIFDEVMTGF-RVALGGAQAYYGVT-- 265 Query: 350 ADVMTFSK----KMMTGGFFHKEEFR----PNAPYRIFNTWLGDPSKNLLLAEVINIIKR 401 D+ TF K M G F K E P P T G+P + +I R Sbjct: 266 PDLSTFGKIIGGGMPVGAFGGKREIMQQISPLGPVYQAGTLSGNPLAMAAGLTTLRLISR 325 Query: 402 EDLLSNAAHAGKVLLTGLLDLQ 423 +L GL Sbjct: 326 PGFHDELTAYTTRMLDGLQQRA 347 >5HDM-A nrPDB Length = 434 Score = 229 bits (583), Expect = 3e-60, Method: Composition-based stats. Identities = 75/443 (16%), Positives = 142/443 (32%), Gaps = 71/443 (16%) Query: 74 FCNYEESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGI 133 + +G+ + D+DGN +D IG++ ++ + + T P L Sbjct: 42 PVLIDSVKGSKMWDIDGNEYIDYVGSWGPAIIGHADDEVLAALAETMKKGTSFGAPCL-- 99 Query: 134 LPPENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEE 193 L E ++S P + + + G+ + + + Sbjct: 100 -----LENVLAEMVISAVPS-IEMVRFVNSGTEACMGVLRLARAFTN------------- 140 Query: 194 LETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKY 253 + F G +HG L S + + +P D P P Sbjct: 141 -------------KEKFIKFEGCYHGHANAFLVKAGS-GVATLGLP--DSPGVP------ 178 Query: 254 PLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLR 313 + + LE VE L ++ ++ +I+EP+ G + +F LR Sbjct: 179 --KAATSDTLTAPYNDLEAVEKLFAAHK---GEISAVILEPVVGNSGFIPPTPEFINGLR 233 Query: 314 DISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGFFHK------ 367 +++ +G + DEV TG A E++G+ D+ T K + G Sbjct: 234 QLTKDNGVLLIFDEVMTGF-RLAYGGAQEYFGIT--PDLTTLGKIIGGGLPVGAYGGRRD 290 Query: 368 --EEFRPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDLQAR 425 E P P T G+P + +K+ K L G+L+ + Sbjct: 291 IMEMVAPAGPMYQAGTLSGNPLAMTAGIHTLKRLKQAGTYEYLDKITKELTNGILEAGKK 350 Query: 426 --YPQFISRVRGR-GTFCSFDTPDESIRNKLISIARNKGVMLGGCGDKSIRFRP------ 476 +P + G G F + + P + + S G G ++ + F P Sbjct: 351 TGHPMCGGYISGMFGFFFA-EGPVYNFADSKKSDTEKFGRFFRGMLEEGVYFAPSQFEAG 409 Query: 477 --TLVFRDHHAHLFLNIFSDILA 497 +L L + +L+ Sbjct: 410 FTSLAHTPEDIQLTIAAAERVLS 432 >2E7U-A nrPDB Length = 424 Score = 226 bits (575), Expect = 2e-59, Method: Composition-based stats. Identities = 78/451 (17%), Positives = 141/451 (31%), Gaps = 89/451 (19%) Query: 74 FCNYEESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGI 133 G Y+ D DGNR LD + +G++HP ++ V++ P+ Sbjct: 35 PPFLVRGEGAYVWDADGNRYLDYVMSWGPLILGHAHPKVLARVRETLERGLTFGAPS--- 91 Query: 134 LPPENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEE 193 L + + P + + + G+ + +A + + Sbjct: 92 ----PLEVALAKKVKRAYPF-VDLVRFVNSGTEATMSALRLARGYTG------------- 133 Query: 194 LETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKY 253 I+ F G +HG G L S A+ + +PS + +L Sbjct: 134 -------------RPYIVKFRGNYHGHADGLLVEAGSGAL-TLGVPSSAGVPEEYAKLTL 179 Query: 254 PLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLR 313 LE E L +++ + +A II EP+ G ++DF + L Sbjct: 180 VLEYNDPEG-------------LREVLKRRGEEIAAIIFEPVVGNAGVLVPTEDFLKALH 226 Query: 314 DISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGFFHK------ 367 + ++ +G + DEV TG A E GL D++T K + G Sbjct: 227 E-AKAYGVLLIADEVMTGF-RLAFGGATELLGLK--PDLVTLGKILGGGLPAAAYAGRRE 282 Query: 368 --EEFRPNAPYRIFNTWLGDPSKNLLLAEVINIIKR-EDLLSNAAHAGKVLLTGLLDLQA 424 E+ P P T G+P + +++ + G L GL ++ Sbjct: 283 IMEKVAPLGPVYQAGTLSGNPLAMAAGLATLELLEENPGYYAYLEDLGARLEAGLKEVLK 342 Query: 425 R--YPQFISRVRGRGTFCSFDTP--------DESIRNKLISIARNKGVMLGGCGDKSIRF 474 P ++RV G+ + D + + G++ G + Sbjct: 343 EKGLPHTVNRV---GSMITVFFTEGPVVTFQDARRTDTELFKRFFHGLLDRGI------Y 393 Query: 475 RPTLVFR---------DHHAHLFLNIFSDIL 496 P F + L L Sbjct: 394 WPPSNFEAAFLSVAHREEDVEKTLEALRKAL 424 >2EPJ-A nrPDB Length = 434 Score = 207 bits (527), Expect = 7e-54, Method: Composition-based stats. Identities = 85/443 (19%), Positives = 146/443 (32%), Gaps = 79/443 (17%) Query: 52 GPRSRELMKQ--------LNIIQNAEAVHFFCNYEESRGNYLVDVDGNRMLDLYSQISSI 103 G +SR L ++ +N A + + G YL VDG R++DL + Sbjct: 9 GEKSRMLFERTKELFPGGVNSPVRAAVKPYPFYVKRGEGAYLYTVDGARIVDLVLAYGPL 68 Query: 104 PIGYSHPALVKLVQQPQNVSTFINRPALGILPPENFVEKLRESLLSVAPKGMSQLITMAC 163 +G+ HP +++ V++ + R L P E V + L V GM + + Sbjct: 69 ILGHKHPRVLEAVEEA------LARGWLYGAPGEAEVLLAEKILGYVKRGGMIR--FVNS 120 Query: 164 GSCSNENAFKTIFMWYRSKERGQSAFSKEELETCMINQAPGCPDYSILSFMGAFHGRTMG 223 G+ + A + + IL F G +HG Sbjct: 121 GTEATMTAIRLARGYTG--------------------------RDLILKFDGCYHGSHDA 154 Query: 224 CLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKK 283 L S A H P E + +E +E + +Y Sbjct: 155 VLVAAGSAAAH-----------YGVPTSAGVPEAVARLTLVTPYNDVEALERVFAEY--- 200 Query: 284 KKTVAGIIVEPIQSEGGDNHASDDFFRKLRDISRKHGCAFLVDEVQTGGGSTGKFWAHEH 343 +AG+IVEP+ + G +F L+ +SR+ G ++DEV TG G A + Sbjct: 201 GDRIAGVIVEPVIANAGVIPPRREFLAALQRLSRESGALLILDEVVTGF-RLGLEGAQGY 259 Query: 344 WGLDDPADVMTFSKKMMTGGFFHKEE--------FRPNAPYRIFNTWLGDPSKNLLLAEV 395 + ++ D++ K + G P T+ P Sbjct: 260 FNIE--GDIIVLGKIIGGGFPVGAVAGSREVMSLLTPQGKVFNAGTFNAHPITMAAGLAT 317 Query: 396 INIIKREDLLSNAAHAGKVLLTGLLDLQAR--YPQFISRVR-GRGTFCSFDTPDESIRN- 451 + ++ E + S + A K L ++ R P I+RV F + + + Sbjct: 318 LKALEEEPVYSVSREAAKALEEAASEVLDRTGLPYTINRVESMMQLFIGVEEVSNAAQAR 377 Query: 452 --------KLISIARNKGVMLGG 466 KL +GV + Sbjct: 378 KADKKFYVKLHEEMLRRGVFIAP 400 >4ZM4-A nrPDB Length = 447 Score = 162 bits (411), Expect = 2e-40, Method: Composition-based stats. Identities = 68/411 (16%), Positives = 132/411 (32%), Gaps = 55/411 (13%) Query: 40 DYDGPLMKTEVPGPRSRELMKQLNIIQNAEAVHFFCNYEESRGNYLVDVDGNRMLDLYSQ 99 D D P + G +S + ++ A AV + G L DV+ ++DL Sbjct: 8 DADRPTNAESLDGIKS-VIAGGVSSSMRAAAVPLPLVVRSAGGCLLRDVEDGEIIDLNMG 66 Query: 100 ISSIPIGYSHPALVKLVQQPQNVSTFINRPALGILPPENFVEKLRESLLSVAPKGMSQLI 159 GY+ ++ V P + + + P G+ Q+ Sbjct: 67 YGPHLFGYADREVLDAVADQFAKGHMTGLP-------HELDARAGALIAELVP-GVEQVR 118 Query: 160 TMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELETCMINQAPGCPDYSILSFMGAFHG 219 G+ + +A + +++F G +HG Sbjct: 119 FANSGTEAVASALRLARA--------------------------TTGRTLVVTFEGHYHG 152 Query: 220 RTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFVKENQQEEARCLEEVEDLIVK 279 + L A+H P P + E + Q + + +L Sbjct: 153 WSETVLRA-GKTALHMEGT----RPTDVVPGALGMIPEALAHTVQLGWNDPDALRELFA- 206 Query: 280 YRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDISRKHGCAFLVDEVQTGGGSTGKFW 339 + +A +IVEP+ + G + F + LR+++ + G + DEV TG + Sbjct: 207 --RDGDRIAAVIVEPVLANAGVIPPAPGFLQLLRELTGRSGAMLVFDEVITGF-RVARGG 263 Query: 340 AHEHWGLDDPADVMTFSKKMMTGGFF-------HKEEFRPNAPYRIFNTWLGDPSKNLLL 392 A E +G++ D+ S+ M G H + + G+ + + Sbjct: 264 AQERYGVE--PDLTVLSRVMGGGFPVAAFGGRRHAMRMLASNEAHHAGVYAGNHAALRAV 321 Query: 393 AEVI-NIIKREDLLSNAAHAGKVLLTGLLDLQARYPQFISRVRGRGTFCSF 442 ++ I DL G+ + + ++ A + + R GT S Sbjct: 322 VAMLGKIRSLPDLYERLEDTGQYMEDTVREVFATEKRPVHINR-VGTLMSV 371 >2CY8-A nrPDB Length = 453 Score = 155 bits (391), Expect = 4e-38, Method: Composition-based stats. Identities = 61/361 (16%), Positives = 117/361 (32%), Gaps = 64/361 (17%) Query: 75 CNYEESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGIL 134 +++G + DVDGN LD + ++ +G+ HP + + + + Sbjct: 41 LFISDAQGVHKTDVDGNVYLDFFGGHGALVLGHGHPRVNAAIAEAL-------SHGVQYA 93 Query: 135 PPENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEEL 194 + E +++ P + +L G+ + A + + + Sbjct: 94 ASHPLEVRWAERIVAAFPS-IRKLRFTGSGTETTLLALRVARAFTGRR------------ 140 Query: 195 ETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYP 254 IL F G +HG + FD AP + Sbjct: 141 --------------MILRFEGHYHGWHDFSASG---------YNSHFDGQPAPGVLPETT 177 Query: 255 LEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRD 314 + +++E + + +A I EP+ S G SD F R+ + Sbjct: 178 ANTLLIRP--------DDIEGMREVFANHGSDIAAFIAEPVGSHFGVTPVSDSFLREGAE 229 Query: 315 ISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGFFHKEEFRPNA 374 ++R++G F++DEV +G G + LD D+ +K G R + Sbjct: 230 LARQYGALFILDEVISGF-RVGN-HGMQAL-LDVQPDLTCLAKASAGGLPGGILGGREDV 286 Query: 375 PY----------RIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDLQA 424 T+ G+P I+ I +D+ + G+ + L A Sbjct: 287 MGVLSRGSDRKVLHQGTFTGNPITAAAAIAAIDTILEDDVCAKINDLGQFAREAMNHLFA 346 Query: 425 R 425 R Sbjct: 347 R 347 >4AOA-A nrPDB Length = 454 Score = 147 bits (370), Expect = 1e-35, Method: Composition-based stats. Identities = 57/363 (15%), Positives = 102/363 (28%), Gaps = 75/363 (20%) Query: 71 VHFFCNYEESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPA 130 F G L D DG+R D ++ ++ G+S P + V + Sbjct: 67 APFPLTIARGEGAALWDADGHRYADFIAEYTAGVYGHSAPEIRDAVIEAMQ-------GG 119 Query: 131 LGILPPENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFS 190 + + +L + P+ + QL G+ +N A + + Sbjct: 120 INLTGHNLLEGRLARLICERFPQ-IEQLRFTNSGTEANLMALTAALHFTGRR-------- 170 Query: 191 KEELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPR 250 I+ F G +HG G L + + P Sbjct: 171 ------------------KIVVFSGGYHG---GVLGFGARPSPTTVPFDFLVLP------ 203 Query: 251 LKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFR 310 + + + + +A ++VEP+Q G DF + Sbjct: 204 -------------------YNDAQTARAQIERHGPEIAVVLVEPMQGASGCIPGQPDFLQ 244 Query: 311 KLRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSK----KMMTGGFFH 366 LR+ + + G + DEV T G+ D+ T K M G F Sbjct: 245 ALRESATQVGALLVFDEVMT--SRLAPHGLANKLGIRS--DLTTLGKYIGGGMSFGAFGG 300 Query: 367 KEEFRPN-----APYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLD 421 + + P T+ + + + + A G+ L L Sbjct: 301 RADVMALFDPRTGPLAHSGTFNNNVMTMAAGYAGLTKLFTPEAAGALAERGEALRARLNA 360 Query: 422 LQA 424 L A Sbjct: 361 LCA 363 >4A0G-A nrPDB Length = 831 Score = 132 bits (332), Expect = 3e-31, Method: Composition-based stats. Identities = 72/463 (15%), Positives = 127/463 (27%), Gaps = 76/463 (16%) Query: 95 DLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGILPPENFVEKLRESLLSVAPKG 154 D + + G +L ++ + E K E LL KG Sbjct: 384 DACASWWT--QGPDPTFQAELAREMGYTAARFGHVMFPENVYEP-ALKCAELLLDGVGKG 440 Query: 155 M-SQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELETCMINQAPGCPDYSILSF 213 S++ GS + E A K F + C + +++ Sbjct: 441 WASRVYFSDNGSTAIEIALKMAFR-----------KFCVDHNFCEATEEEKHIVVKVIAL 489 Query: 214 MGAFHGRTMGCLATTHSKAI-------HKIDIPSFDWPI--------------APFPRLK 252 G++HG T+G + F P F + Sbjct: 490 RGSYHGDTLGAMEAQAPSPYTGFLQQPWYTGRGLFLDPPTVFLSNGSWNISLPESFSEIA 549 Query: 253 YPLEEFVKENQQEE-ARCLEEVEDLIVKYR----------KKKKTVAGIIVEP-IQSEGG 300 F ++ + +R + + Y ++ V +I+EP I GG Sbjct: 550 PEYGTFTSRDEIFDKSRDASTLARIYSAYLSKHLQEHSGVRQSAHVGALIIEPVIHGAGG 609 Query: 301 DNHASDDFFRKLRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMM 360 + F R L + R + DEV TG G E G D+ F+K + Sbjct: 610 MHMVDPLFQRVLVNECRNRKIPVIFDEVFTGFWRLGVETTTELLGCK--PDIACFAKLLT 667 Query: 361 TGGFFHKEEFRPNAPYR------------IFNTWLGDPSKNLLLAEVINIIKREDLLSNA 408 G +A + +++ A+ I K + N Sbjct: 668 GGMVPLAVTLATDAVFDSFSGDSKLKALLHGHSYSAHAMGCATAAKAIQWFKDPETNHNI 727 Query: 409 AHAGKVLL----TGLLDLQARYPQFISRVRGRGTFCSFDTPDESIRNKLISI-------- 456 GK L L+ + + + RV GT + + ++ + S+ Sbjct: 728 TSQGKTLRELWDEELVQQISSHSA-VQRVVVIGTLFALELKADASNSGYASLYAKSLLIM 786 Query: 457 ARNKGVMLGGCGDKSIRFRPTLVFRDHHAHLFLNIFSDILADF 499 R G+ G+ L L +F Sbjct: 787 LREDGIFTRPLGNVIYLMCGPCT-SPEICRRLLTKLYKRLGEF 828 >2YKV-A nrPDB Length = 465 Score = 130 bits (327), Expect = 1e-30, Method: Composition-based stats. Identities = 75/443 (16%), Positives = 133/443 (30%), Gaps = 82/443 (18%) Query: 72 HFFCNYEESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPAL 131 F + G+ DVDG+ ++ + ++ G+SHP + V++ V L Sbjct: 81 PFPLVIAQGTGSRFQDVDGHAYVNFLGEYTAGLFGHSHPVIRAAVERALAV-------GL 133 Query: 132 GILPPENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSK 191 + E++ P + + G+ +N A T K Sbjct: 134 NLSTQTENEALFAEAVCDRFPS-IDLVRFTNSGTEANLMALATATAITGRK--------- 183 Query: 192 EELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRL 251 ++L+F G +HG + +F AP Sbjct: 184 -----------------TVLAFDGGYHG-----------------GLLNFASGHAPTNAP 209 Query: 252 KYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRK 311 + +VE ++ A I+VEP+ GG A F Sbjct: 210 YH-----------VVLGVYNDVEGTADLLKRHGHDCAAILVEPMLGAGGCVPAERAFLDL 258 Query: 312 LRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSK----KMMTGGFFHK 367 LR + + G + DEV T A E G+ AD+ T K M G F + Sbjct: 259 LRAEASRCGALLIFDEVMT--SRLSGGGAQEMLGIS--ADLTTLGKYIGGGMSFGAFGGR 314 Query: 368 EEFRP------NAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLD 421 + + + T+ + + I S+ + +G L Sbjct: 315 RDLMERFDPARDGAFAHAGTFNNNILTMSAGHAALTQIYTRQAASDLSASGDRFRANLNR 374 Query: 422 LQARYPQFISRVRGRGTFCSFDTPDESIRNK---LISIARNKGVMLGGCGDKSIRFRP-- 476 + + + G G+ + IR+ + + K + K I P Sbjct: 375 IAVENQAPL-QFTGLGSLGTIHFSRAPIRSAGDVRAADQQLKELFFFHMLRKGIYLAPRG 433 Query: 477 TLVFRDHHAHLFLNIFSDILADF 499 A + F++ LADF Sbjct: 434 MYALSLEIADAGRDAFAEALADF 456 >5YKR-A nrPDB Length = 461 Score = 116 bits (291), Expect = 2e-26, Method: Composition-based stats. Identities = 52/371 (14%), Positives = 100/371 (26%), Gaps = 75/371 (20%) Query: 74 FCNYEESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGI 133 +E++G + D+DG + +D S G++ PA+ + + + + P Sbjct: 58 PLLVKEAQGARVTDIDGQQYVDFALGDSGAMFGHAQPAVADAIARQARRGSTLMLPTEDS 117 Query: 134 LPPENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEE 193 L +L G+ + +N + M Sbjct: 118 LW---VGAELARRF------GLPYWQVTTSATDANRFVLRLCRML--------------- 153 Query: 194 LETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKY 253 ++ F +HG FD PR Sbjct: 154 -----------SGRDKVVVFNCNYHGSVDESQV-------------EFDAAGRMVPRAGV 189 Query: 254 PLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLR 313 V+ +++ L VA ++ EP + G ++ F LR Sbjct: 190 -HPNGVRHATTTRLVEFNDLDALEAALAHG--DVAAVLTEPFMTNVGMVPPAEGFHAGLR 246 Query: 314 DISRKHGCAFLVDEVQT-GGGSTGKFWAHEHWGLDDPADVMTFSKKMMTG---GFFHKEE 369 +++R+H A ++DE T G G AH D K + G + + Sbjct: 247 ELTRRHDVALIIDETHTISCGPAGYSGAHGLE-----PDFFVLGKCIAGGIPSAVWGCSQ 301 Query: 370 FRPNAPY---------------RIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKV 414 + + T G+ + + + ED + Sbjct: 302 AQAERIWAVLPHFRPGQAINHFGFGGTLAGNALQLAAMRATFAEVMTEDAYRHMFQLAAQ 361 Query: 415 LLTGLLDLQAR 425 L G+ Sbjct: 362 LEAGVRATLEE 372 >5Z8A-A nrPDB Length = 437 Score = 69.0 bits (167), Expect = 5e-12, Method: Composition-based stats. Identities = 54/430 (12%), Positives = 115/430 (26%), Gaps = 86/430 (20%) Query: 74 FCNYEESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGI 133 + E G YL D DG R +D + S+ +G+ + + + + + + Sbjct: 45 PRVFVEGSGAYLTDPDGRRWIDFDNARGSVVLGHGDEEVAEAIARAARGRSGVGTAW--- 101 Query: 134 LPPENFVEKLRESLLSVAPKGMSQLITMACGS-CSNENAFKTIFMWYRSKERGQSAFSKE 192 ++ L L V + L + S A + Sbjct: 102 ---SPVLDSLLGQLQEVCGGDVVGLYRTGTAALRSVTCAVRDAR---------------- 142 Query: 193 ELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLK 252 + +HG P Sbjct: 143 ---------------DRSIVLSSGYHG-------------------------YDPMWHCD 162 Query: 253 YPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKL 312 P NQ L ++ D++ ++ + + VA +++ P G + ++ + Sbjct: 163 EPFT----PNQHGIVEFLFDL-DVLAEWLSRPEQVAAVVISPDHMHLG-----ERWYTEF 212 Query: 313 RDISRKHGCAFLVDEVQTGGG-STGKFWAHEHWGLDDPADVM--TFSKKMMTGGFFHKEE 369 ++++ + DEV+ G G LD ++ + Sbjct: 213 TRLTKEADVPVIADEVKVGLRYRAG----LSTPLLDPAVWIVAKCLANGSPVAAVGGDAH 268 Query: 370 FRPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDLQARYPQF 429 F ++ +P+ + + + AG + A Sbjct: 269 LLAALEDVSFTSYF-EPTAMAAATTTLRRMATGEPQQAIRAAGDRFIAHTRAAFANAGVP 327 Query: 430 ISRVRGRGTFCSFDTPDESIRNKLISIARNKGVMLGGCGDKSIRFRPTLVFRDHHAHLFL 489 I + G G F D+ + + + A +G++ GD P+ F D Sbjct: 328 I-DLAGNGNLFQFVCADDEVADAFHAAAAAEGLLFFE-GDNQ---TPSAAFTDEVVEDAC 382 Query: 490 NIFSDILADF 499 + A Sbjct: 383 GRIDRVSAAL 392 >6CBN-A nrPDB Length = 438 Score = 60.5 bits (145), Expect = 1e-09, Method: Composition-based stats. Identities = 46/294 (15%), Positives = 82/294 (27%), Gaps = 74/294 (25%) Query: 74 FCNYEESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGI 133 + + G +L D G R +D + SI +G+ P + + V + + Sbjct: 44 PRVFTAASGAWLTDESGFRWIDFDNARGSILLGHGDPVVAEAVARAATGADGTATGW--- 100 Query: 134 LPPENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEE 193 V+ + E L ++ + L +S + Sbjct: 101 ---SRRVDAVLERLHALCGGEVVGLF--------------------------RSGTAAVR 131 Query: 194 LETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKY 253 + +A G P L +HG +D P Sbjct: 132 AAVLAVREATGRP----LLLSAGYHG---------------------YDPMWYPSEAPLE 166 Query: 254 PLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLR 313 P + L+ + + + VA ++V P H S ++R+LR Sbjct: 167 P--------NADGVVDFFFDLGLLRELLRAPERVAAVVVSPDH-----MHLSPGWYRELR 213 Query: 314 DISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGFFHK 367 + G + DEV+ G E DV +K M G Sbjct: 214 RLCSAAGVVLVADEVKVGLRYAPGLSTAELL----APDVWVVAKGMANGHAVSA 263 >3WY7-A nrPDB Length = 404 Score = 53.9 bits (128), Expect = 2e-07, Method: Composition-based stats. Identities = 50/234 (21%), Positives = 77/234 (32%), Gaps = 33/234 (14%) Query: 285 KTVAGIIVEPIQSEGGDNHASDDFFRKLRDISRKHGCAFLVDEVQTGGGSTGKFW-AHEH 343 + A ++ E + S GD R L + R+HG LVDE G G G H Sbjct: 185 EERAVVVTESVFSADGDLAP----LRDLHAVCRRHGALLLVDEAH-GLGVRGTRGQGLLH 239 Query: 344 W-GLDDPADVM---TFSKKMM--TGGFFHKEEFRPN----APYRIFNTWLGDPSKNLLLA 393 GL D++ T SK + G E R + A IF+T P+ + Sbjct: 240 EVGLAGAPDIVMTTTLSKALGSQGGAVLGPEAVRAHLIDTARSFIFDT-GLAPAAVGAAS 298 Query: 394 EVINIIKREDLLSNAAHAGKVLLTGLLDLQARYPQFISRVRGRGTFCSFDTPDESIRNKL 453 + ++ E A L + +S V S D I Sbjct: 299 AALRVLDAE--PQRARAVLDRA-AELATIAGVTEAPVSAV------VSVILGDPEIAVGA 349 Query: 454 ISIARNKGVMLG-------GCGDKSIRFRPTLVFRDHHAHLFLNIFSDILADFK 500 + ++GV +G G +R D L + +D+LA + Sbjct: 350 AAACLDRGVRVGCFRPPTVPAGTSRLRLAARASLTDDEMALARQVLTDVLATAR 403 >3TQX-A nrPDB Length = 399 Score = 53.2 bits (126), Expect = 2e-07, Method: Composition-based stats. Identities = 38/211 (18%), Positives = 68/211 (32%), Gaps = 36/211 (17%) Query: 309 FRKLRDISRKHGCAFLVDEV-QTGG----GSTGKFWAHEHWGLDDPADVMT--FSKKMMT 361 + + D++ K+ +VD+ G G G E+ G+ D D++T K + Sbjct: 194 LKSICDLADKYNALVMVDDSHAVGFIGENGR-GTP---EYCGVADRVDILTGTLGKALGG 249 Query: 362 --GGF--FHKEEF----RPNAPYRIFNTWLGDPSKNLLLAEVINIIKRED--LLSNAAHA 411 GG+ HKE + PY NT P +V+ ++K E L Sbjct: 250 ASGGYTSGHKEIIEWLRNRSRPYLFSNTVA--PVIVATSLKVLELLKTEGPQLRKQLQEN 307 Query: 412 GKVLLTGLLDLQARYPQFISRVRGRGTFCSFDTPDESIRNKLISIARNKGVMLG------ 465 + G+ L + V G D + + +G+ + Sbjct: 308 SRYFRAGMEKLGFQL------VPGNHPIIPVMLGDAQLATNMADHLLQEGIYVVGFSYPV 361 Query: 466 -GCGDKSIRFRPTLVFRDHHAHLFLNIFSDI 495 G IR + + V + F + Sbjct: 362 VPMGKARIRVQMSAVHTQQQLDRAIEAFGQV 392 >6HRH-B nrPDB Length = 469 Score = 46.6 bits (109), Expect = 3e-05, Method: Composition-based stats. Identities = 45/251 (17%), Positives = 79/251 (31%), Gaps = 45/251 (17%) Query: 268 RCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDISRKHGCAFLVDE 327 + ++ L+ K K + E + S G +L D+S ++G VDE Sbjct: 187 NDPDHLKKLLEKSNPKIPKIVAF--ETVHSMDGAICP----LEELCDVSHQYGALTFVDE 240 Query: 328 V-QTGG-GSTGKFWAHEHWGLDDPADVM--TFSKKMM-TGGFFHK-----EEFRPNAPYR 377 V G GS G E G+ D++ T K GG+ + R A Sbjct: 241 VHAVGLYGSRGAGIG-ERDGIMHKIDIISGTLGKAFGCVGGYIASTRDLVDMVRSYAAGF 299 Query: 378 IFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDLQARYPQFISRVRGRG 437 IF T P E + ++K E+ A + + + L RG Sbjct: 300 IFTT-SLPPMVLSGALESVRLLKGEE-GQALRRAHQRNVKHMRQLLMD----------RG 347 Query: 438 T--------FCSFDTPDESIRNKLISIAR-NKGVML-------GGCGDKSIRFRPTLVFR 481 + ++ +KL + G+ + G++ +R P+ Sbjct: 348 LPVIPCPSHIIPIRVGNAALNSKLCDLLLSKHGIYVQAINYPTVPRGEELLRLAPSPHHS 407 Query: 482 DHHAHLFLNIF 492 F+ Sbjct: 408 PQMMEDFVEKL 418 >1FC4-A nrPDB Length = 401 Score = 45.5 bits (106), Expect = 6e-05, Method: Composition-based stats. Identities = 39/255 (15%), Positives = 85/255 (33%), Gaps = 43/255 (16%) Query: 266 EARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDISRKHGCAFLV 325 ++E+E + + R+ I + + S G + + D++ K+ +V Sbjct: 157 ANNDMQELEARLKEAREAGARHVLIATDGVFSMDGVIAN----LKGVCDLADKYDALVMV 212 Query: 326 DEV-QTGG-GSTGKFWAHEHWGLDDPADVM--TFSKKMM---TGGFFHKEEFRP-----N 373 D+ G G G+ +HE+ + D++ T K + G ++E + Sbjct: 213 DDSHAVGFVGENGR-GSHEYCDVMGRVDIITGTLGKALGGASGGYTAARKEVVEWLRQRS 271 Query: 374 APYRIFNTWLGDPSKNLLLAEVINIIK-----REDLLSNAAHAGKVL-LTGLLDLQARYP 427 PY N+ P+ +V+ +++ R+ L +NA + + G A + Sbjct: 272 RPYLFSNSLA--PAIVAASIKVLEMVEAGSELRDRLWANARQFREQMSAAGFTLAGADH- 328 Query: 428 QFISRVRGRGTFCSFDTPDESIRNKLISIARNKGVM-------LGGCGDKSIRFRPTLVF 480 D + K + +G+ + G IR + + Sbjct: 329 ----------AIIPVMLGDAVVAQKFARELQKEGIYVTGFFYPVVPKGQARIRTQMSAAH 378 Query: 481 RDHHAHLFLNIFSDI 495 + F+ I Sbjct: 379 TPEQITRAVEAFTRI 393 >3HQT-A nrPDB Length = 409 Score = 45.1 bits (105), Expect = 8e-05, Method: Composition-based stats. Identities = 56/289 (19%), Positives = 91/289 (31%), Gaps = 36/289 (12%) Query: 228 THSKAIHKIDIPSFDWPIAPFPRLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTV 287 + + I P+ + I F + E N Q + L + ++ + Sbjct: 131 ANVGLLQTICQPNTNVYIDFFAHMSL-WEGARYANAQAHPFMHNNCDHLRMLIQRHGPGI 189 Query: 288 AGIIVEPIQSEGGDNHASDDFFRKLRDISRKHGCAFLVDEVQTGGGSTGKFWA--HEHWG 345 I+V+ I S G +L +IS++ GCA LVDE + G+ G A G Sbjct: 190 --IVVDSIYSTLGTIAP----LAELVNISKEFGCALLVDESHS-LGTHGPNGAGLLAELG 242 Query: 346 LDDPADVMT--FSKKMM--TGGFFHKEEFRPNAP-----YRIFNTWLGDPSKNLLLAEVI 396 L MT +K G + E P +T L P + L + Sbjct: 243 LTREVHFMTASLAKTFAYRAGAIWCNNEVNRCVPFISYPAIFSSTLL--PYEAAGLETTL 300 Query: 397 NIIK-REDLLSNAAHAGKVLLTGLLDLQARYPQFISRVRGRGTFCSFDTPDESIRNKLIS 455 II+ ++ + + L GL L +R +T DE K+ Sbjct: 301 EIIESADNRRQHLDRMARKLRIGLSQLGLT-------IRSESQIIGLETGDERNTEKVRD 353 Query: 456 IARNKGVM-------LGGCGDKSIRFRPTLVFRDHHAHLFLNIFSDILA 497 + GV IR D + + SD + Sbjct: 354 YLESNGVFGSVFCRPATSKNKNIIRLSLNSDVNDEQIAKIIEVCSDAVN 402 >1O4S-A nrPDB Length = 389 Score = 44.3 bits (103), Expect = 1e-04, Method: Composition-based stats. Identities = 50/345 (14%), Positives = 89/345 (25%), Gaps = 30/345 (8%) Query: 168 NENAFKTIFM--WYRSKERGQSAFSKEELETCMINQAPGCPDYSILSFMGAFHGRTMGCL 225 E A + + + RG + + ++ GA + Sbjct: 60 VEEAVRFLQKGEVKYTDPRGIYELREGIAKRIGERYKKDISPDQVVVTNGAKQALFNAFM 119 Query: 226 ATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKK 285 A + P + I + + LEEVE L+V K Sbjct: 120 ALLDPGDEVIVFSPVWVSYIPQIILAGGTVNVVETFMSKNFQPSLEEVEGLLV-----GK 174 Query: 286 TVAGIIVEPIQSEGGDNHASDDFFRKLRDISRKHGCAFLVDEVQTGGGSTGKFWAH--EH 343 T A +I P G +F L +++K + DEV T +F + Sbjct: 175 TKAVLINSPNNPTG--VVYRREFLEGLVRLAKKRNFYIISDEVYDSLVYTDEFTSILDVS 232 Query: 344 WGLDDPADVMTFSK-----KMMTGGFFHKEEFRPNAPYRIFNTWLG-DPSKNLLLAEVIN 397 G D + FSK G E+ +T + + + Sbjct: 233 EGFDRIVYINGFSKSHSMTGWRVGYLISSEKVATAVSKIQSHTTSCINTVAQYAALKALE 292 Query: 398 IIKREDLLSNAAHAGKVLLTGLLDLQARYPQFISRVRGRGTFCSFDTPDESIRNKLISIA 457 + ++ ++ L + ++ V G F F + Sbjct: 293 V-DNSYMVQTFKERKNFVVERLKKMGVKF------VEPEGAFYLFFKVRGDDVKFCERLL 345 Query: 458 RNKGVMLGG----CGDKSIRFRPTLVFRDHHAHLFLNIFSDILAD 498 K V L +R + L+ D L Sbjct: 346 EEKKVALVPGSAFLKPGFVRL--SFATSIERLTEALDRIEDFLNS 388 >2BWN-A nrPDB Length = 401 Score = 40.5 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 38/169 (22%), Positives = 57/169 (33%), Gaps = 23/169 (13%) Query: 268 RCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDISRKHGCAFLVDE 327 + + +LI + E + S GD +++ DI+ + G +DE Sbjct: 162 NDVAHLRELIAADDPAAPKLIAF--ESVYSMDGDFGP----IKEICDIAEEFGALTYIDE 215 Query: 328 V-QTGG-GSTGKFWAHEHWGLDDPADVM--TFSKKMMT-GGFFHK-----EEFRPNAPYR 377 V G G G A E GL D+ T +K GG+ + R AP Sbjct: 216 VHAVGMYGPRGAGVA-ERDGLMHRIDIFNGTLAKAYGVFGGYIAASARMVDAVRSYAPGF 274 Query: 378 IFNTWLGDPSKNLLL----AEVINIIKREDLLSNAAHAGKVLLTGLLDL 422 IF+T L P + + + L KVL L L Sbjct: 275 IFSTSL--PPAIAAGAQASIAFLKTAEGQKLRDAQQMHAKVLKMRLKAL 321 >4WP0-A nrPDB Length = 472 Score = 39.3 bits (90), Expect = 0.004, Method: Composition-based stats. Identities = 18/142 (12%), Positives = 40/142 (28%), Gaps = 20/142 (14%) Query: 309 FRKLRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPAD-------VMTFSKKMMT 361 + + ++H + DEV + H+H + + + K Sbjct: 196 LELVASLCQQHDVVCITDEVYQWM----VYDGHQHISIASLPGMWERTLTIGSAGKTFSA 251 Query: 362 GGFFHKEEFRPNAPYRIFNTWLGD-----PSKNLLLAEVINIIKREDLLSNAAHAGKVLL 416 G+ P+ + T + P+++ +RE LL + Sbjct: 252 TGWKVGWVLGPDHIMKHLRTVHQNSVFHCPTQSQAAVA--ESFEREQLLFR--QPSSYFV 307 Query: 417 TGLLDLQARYPQFISRVRGRGT 438 +Q I ++ G Sbjct: 308 QFPQAMQRCRDHMIRSLQSVGL 329 >3FVS-A nrPDB Length = 422 Score = 39.3 bits (90), Expect = 0.004, Method: Composition-based stats. Identities = 18/142 (12%), Positives = 40/142 (28%), Gaps = 20/142 (14%) Query: 309 FRKLRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPAD-------VMTFSKKMMT 361 + + ++H + DEV + H+H + + + K Sbjct: 196 LELVASLCQQHDVVCITDEVYQWM----VYDGHQHISIASLPGMWERTLTIGSAGKTFSA 251 Query: 362 GGFFHKEEFRPNAPYRIFNTWLGD-----PSKNLLLAEVINIIKREDLLSNAAHAGKVLL 416 G+ P+ + T + P+++ +RE LL + Sbjct: 252 TGWKVGWVLGPDHIMKHLRTVHQNSVFHCPTQSQAAVA--ESFEREQLLFR--QPSSYFV 307 Query: 417 TGLLDLQARYPQFISRVRGRGT 438 +Q I ++ G Sbjct: 308 QFPQAMQRCRDHMIRSLQSVGL 329 >1V2E-A nrPDB Length = 381 Score = 38.2 bits (87), Expect = 0.008, Method: Composition-based stats. Identities = 29/211 (13%), Positives = 47/211 (22%), Gaps = 31/211 (14%) Query: 309 FRKLRDISRKHGCAFLVDEVQTGG-----GSTGKFWAHEHWGLDDPADVMTFSKKMMTGG 363 + ++R H + DEV + +A E A + G Sbjct: 174 LEAIARLARAHDLFLISDEVYDELYYGERPRRLREFAPERTFTVGSAGKRLEATGYRVGW 233 Query: 364 FFHKEEFRPNAPYRIFNTWLGDPSKNLLLAE-VINIIKREDLLSNAAHAGKVLLTGLLDL 422 +EF P T P+ + + +RE L G Sbjct: 234 IVGPKEFMPRLAGMRQWTSFSAPTPLQAGVAEALKLARREGFYEA-------LREGYRR- 285 Query: 423 QARYPQFISRVRGRGTFCSF-----DTPDESIRNKLISIARNKGVMLGGCGD-------- 469 R +R G E + V L Sbjct: 286 --RRDLLAGGLRAMGLRVYVPEGTYFLMAELPGWDAFRLVEEARVALIPASAFYLEDPPK 343 Query: 470 KSIRFRPTLVFRDHHAHLFLNIFSDILADFK 500 RF + HL L ++ + Sbjct: 344 DLFRFA--FCKTEEELHLALERLGRVVNSPR 372 >5TXT-B nrPDB Length = 491 Score = 37.8 bits (86), Expect = 0.012, Method: Composition-based stats. Identities = 48/265 (18%), Positives = 77/265 (29%), Gaps = 44/265 (16%) Query: 166 CSNENAFKTIFMWYRSKERGQS-AFSKEELETCMINQAPGCPDYSILSFMGAFHGRTMGC 224 + KTI + ++ A A L F + Sbjct: 74 EVLDAMHKTIDKYGCGAGGTRNIAGHNIPTLNLEAELATLHKKEGALVFSSCYV-ANDAV 132 Query: 225 LATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKK 284 L+ K D+ F + + ++ + + L E+E L+ Y K Sbjct: 133 LSLLGQKMK---DLVIFSDELNHAS-MIVGIKHANVKKHIFKHNDLNELEQLLQSYPKSV 188 Query: 285 KTVAGIIVEPIQSEGGDNHASDDFFRKLRDISRKHGCAFLVDEV-QTGG-GSTGKFWA-- 340 + E + S G K+ D++ K+G +DEV G G G A Sbjct: 189 PKLIAF--ESVYSMAGSVAD----IEKICDLADKYGALTFLDEVHAVGLYGPHGAGVAEH 242 Query: 341 HEHWG-------------------LDDPADVM--TFSKKMMT-GGFFHK-----EEFRPN 373 + + D D++ T K + GG+ + FR Sbjct: 243 CDFESHRASGIATPKTNDKGGAKTVMDRVDMITGTLGKSFGSVGGYVAASRKLIDWFRSF 302 Query: 374 APYRIFNTWLGDPSKNLLLAEVINI 398 AP IF T L PS I Sbjct: 303 APGFIFTTTL-PPSVMAGATAAIRY 326 >1GC4-A nrPDB Length = 385 Score = 37.4 bits (85), Expect = 0.015, Method: Composition-based stats. Identities = 30/207 (14%), Positives = 58/207 (28%), Gaps = 15/207 (7%) Query: 303 HASDDFFRKLRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKM--- 359 + L ++ +H + DE+ G+ ++ + V +K Sbjct: 180 VYPKEVLEALARLAVEHDFYLVSDEIYEHLLYEGEHFSPGRVAPEHTLTVNGAAKAFAMT 239 Query: 360 ---MTGGFFHKEEFRPNAPYRIFNTWLGDPSKNLLLAEVINIIKRED-LLSNAAHAGKVL 415 + KE + A +T D E + + + A A + Sbjct: 240 GWRIGYACGPKEVIKAMASVSRQSTTSPDTIAQWATLEALTNQEASRAFVEMAREAYRRR 299 Query: 416 LTGLLDLQARYPQFISRVRGRGTFCSF--DTPDESIRNKLISIARNKGVMLGGCGDKSIR 473 LL+ + VR G F +P + GV + G Sbjct: 300 RDLLLEGLTALG--LKAVRPSGAFYVLMDTSPIAPDEVRAAERLLEAGVAVVP-GTDFAA 356 Query: 474 F---RPTLVFRDHHAHLFLNIFSDILA 497 F R + + + L F+ +L Sbjct: 357 FGHVRLSYATSEENLRKALERFARVLG 383 >2CH1-A nrPDB Length = 396 Score = 35.8 bits (81), Expect = 0.046, Method: Composition-based stats. Identities = 12/70 (17%), Positives = 22/70 (31%), Gaps = 11/70 (15%) Query: 297 SEGGDNHASDDFFRKLRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFS 356 S G + I +H C +VD V + G + + W + D + Sbjct: 154 SSSGLLQP----LEGVGQICHQHDCLLIVDAVAS---LCGVPFYMDKWEI----DAVYTG 202 Query: 357 KKMMTGGFFH 366 + + G Sbjct: 203 AQKVLGAPPG 212 >3LVM-A nrPDB Length = 423 Score = 35.5 bits (80), Expect = 0.051, Method: Composition-based stats. Identities = 15/122 (12%), Positives = 35/122 (28%), Gaps = 10/122 (8%) Query: 93 MLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGIL----PPENFVEKLRESLL 148 LD + P + + + Q + PA E V+ R + Sbjct: 25 YLDYSATTPV------DPRVAEKMMQFMTMDGTFGNPASRSHRFGWQAEEAVDIARNQIA 78 Query: 149 SVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELETCMINQAPGCPDY 208 + +++ + + S+ A K +Y+ K + E + + Sbjct: 79 DLVGADPREIVFTSGATESDNLAIKGAANFYQKKGKHIITSKTEHKAVLDTCRQLEREGF 138 Query: 209 SI 210 + Sbjct: 139 EV 140 >2X8U-A nrPDB Length = 412 Score = 35.5 bits (80), Expect = 0.052, Method: Composition-based stats. Identities = 50/261 (19%), Positives = 85/261 (32%), Gaps = 36/261 (13%) Query: 256 EEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDI 315 E + +E+++ + + + + +++E + S GD +++ + Sbjct: 146 WLGDAEIVRFRHNSVEDLDKRLGRLPAEAGKL--VVLEGVYSMMGDIAP----LQEMVAV 199 Query: 316 SRKHGCAFLVDEVQTGGGSTGKFWA--HEHWGLDDPADVM--TFSKKMMT-GGFFHKE-- 368 S+KHG LVDE G G G+ E G++ D + TFSK + T GGF Sbjct: 200 SKKHGAMILVDEAH-GMGFFGEHGRGVFEEAGVEADVDFVVGTFSKSVGTVGGFCVSNHP 258 Query: 369 --EFRPNAPYRIFNTWLGDPSKNLLLAEVINII-----KREDLLSNAAHAGKVLLTGLLD 421 E T PS A I + KR L N+ L GL D Sbjct: 259 KFEVLRLVCRPYVFTASLPPSVVATAATSIRKLMHAGDKRAHLWKNSRR----LHQGLRD 314 Query: 422 LQARYPQFISRVRGRGTFCSFDTPDESIRNKLISIARNKGVMLG-------GCGDKSIRF 474 + + ++ + D + L G+ + G +R Sbjct: 315 MGYKLGTETAQ----SAIIAVILTDMAQAVALWQGLLEAGLYVNTARPPATPAGMFLLRC 370 Query: 475 RPTLVFRDHHAHLFLNIFSDI 495 D L +F Sbjct: 371 SLCAEHSDEQVEQILGMFESA 391 >5YHV-A nrPDB Length = 394 Score = 35.5 bits (80), Expect = 0.059, Method: Composition-based stats. Identities = 5/33 (15%), Positives = 9/33 (27%), Gaps = 1/33 (3%) Query: 300 GDNHASDDFFRKLRDISRKHGCAFLVDEVQTGG 332 G ++ + + DEV G Sbjct: 183 GTVIPPEE-LAAIASWCDASDVRLISDEVYHGL 214 >3O59-X nrPDB Length = 300 Score = 35.1 bits (79), Expect = 0.071, Method: Composition-based stats. Identities = 9/60 (15%), Positives = 22/60 (36%), Gaps = 5/60 (8%) Query: 302 NHASDDFFRKLRDISRKHG----CAFLVDEVQTG-GGSTGKFWAHEHWGLDDPADVMTFS 356 ++R++ +++G +VDE+ G G G + + ++T Sbjct: 57 LVGPPGVAERIRELVKEYGKEIAALKIVDEIIDGKFGDLGSKEKYAEQAVRTALAILTEG 116 >5WGB-A nrPDB Length = 426 Score = 35.1 bits (79), Expect = 0.072, Method: Composition-based stats. Identities = 15/105 (14%), Positives = 38/105 (36%), Gaps = 6/105 (5%) Query: 110 PALVKLVQQPQNVSTFINRPALGILPP----ENFVEKLRESLLSVAPKGMSQLITMACGS 165 P ++ + + + P E +E+ R+ + S+ ++I + + Sbjct: 40 PRVLDAM--LPYLINYYGNPHSRTHAYGWESEAAMERARQQVASLIGADPREIIFTSGAT 97 Query: 166 CSNENAFKTIFMWYRSKERGQSAFSKEELETCMINQAPGCPDYSI 210 SN A K + +YRS+++ E ++ + + Sbjct: 98 ESNNIAIKGVARFYRSRKKHLITTQTEHKCVLDSCRSLEAEGFQV 142 >4ISY-A nrPDB Length = 404 Score = 34.7 bits (78), Expect = 0.092, Method: Composition-based stats. Identities = 17/78 (21%), Positives = 30/78 (38%) Query: 109 HPALVKLVQQPQNVSTFINRPALGILPPENFVEKLRESLLSVAPKGMSQLITMACGSCSN 168 HPA ++ + Q + +E+ RE + S++I A G+ S+ Sbjct: 24 HPAAIEAMAAVQRTIGNASSLHTSGRSARRRIEEARELIADKLGARPSEVIFTAGGTESD 83 Query: 169 ENAFKTIFMWYRSKERGQ 186 A K I+ R E + Sbjct: 84 NLAVKGIYWARRDAEPHR 101 >5JAY-A nrPDB Length = 402 Score = 33.9 bits (76), Expect = 0.15, Method: Composition-based stats. Identities = 29/163 (17%), Positives = 49/163 (30%), Gaps = 22/163 (13%) Query: 272 EVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDISRKHGCAFLVDEVQTG 331 + + L V I+ + + S GD +L +++ +HG +VD+ G Sbjct: 166 DTDALSAMLEASDADVKVIVSDTVFSMDGDIAP----LPRLLELAEQHGAWLIVDDAH-G 220 Query: 332 GGSTGK----FWAHEHWGLDDPADVMTFSKKMMTGGFFHKE-----EFRPNAPYRIFNTW 382 G G A + + T K G F E+ T Sbjct: 221 FGVLGPQGRGAIAQAALRSPNLISIGTLDKAAGVSGAFVAAHETVIEWLVQRARPYIFTT 280 Query: 383 LGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDLQAR 425 P+ ++ + II E+ G L L R Sbjct: 281 ASVPAAAHAVSASLRIIGGEE--------GDARRAHLQQLIGR 315 >5W1B-A nrPDB Length = 467 Score = 33.9 bits (76), Expect = 0.18, Method: Composition-based stats. Identities = 44/329 (13%), Positives = 95/329 (28%), Gaps = 99/329 (30%) Query: 159 ITMACGSCSN-----------ENAFKTIFMWYRSKERGQSAFSKEELETCMINQAPGCPD 207 + G+ + + A+ +Y K++ + F+ + + + Sbjct: 48 LLTDSGTNAMSDHQWAAMITGDEAYAGSRNYYDLKDKAKELFNYDYIIPAHQGRGAENIL 107 Query: 208 YSIL-------------SFMGAFHGRTMGC-LATTHSKAIHKIDIPSFDWPIAPFPRLKY 253 + +L F+ FH T + KAI+ + +FD Sbjct: 108 FPVLLKYKQKEGKAKNPVFISNFHFDTTAAHVELNGCKAINIVTEKAFDSETY------- 160 Query: 254 PLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLR 313 + + ++++++ I + + I+ + G S +++ Sbjct: 161 --------DDWKGDFDIKKLKENIA--QHGADNIVAIVSTVTCNSAGGQPVSMSNLKEVY 210 Query: 314 DISRKHGCAFLVD------------------------EVQTGGGSTGKFWAHEHWGLDDP 349 +I+++HG ++D EV + + Sbjct: 211 EIAKQHGIFVVMDSARFCENAYFIKARDPKYKNATIKEVI--------------FDMYKY 256 Query: 350 ADVMTFSKK----MMTGGFFH---KEEFRPNA-----PYRIFNTWLGDPSK---NLLLAE 394 AD +T S K + GG EE A P F T+ G + + Sbjct: 257 ADALTMSAKKDPLLNIGGLVAIRDNEEIFTLARQRCVPMEGFVTYGG--LAGRDMAAMVQ 314 Query: 395 VINI-IKREDLLSNAAHAGKVLLTGLLDL 422 + + E L K L L + Sbjct: 315 GLEEGTEEEYLHYRIGQV-KYLGDRLREA 342 >2DR1-A nrPDB Length = 386 Score = 33.5 bits (75), Expect = 0.19, Method: Composition-based stats. Identities = 42/256 (16%), Positives = 80/256 (31%), Gaps = 39/256 (15%) Query: 274 EDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDISRKHGCAFLVDEVQTGGG 333 EDL RK V + + ++ G + +L ++++H VD V + G Sbjct: 135 EDLDDALRKNPD-VEAVTITYNETSTGVLNP----LPELAKVAKEHDKLVFVDAV-SAMG 188 Query: 334 STGKFWAHEHWGLDDPADVMTFSKKMMTGGFFHK-----EEFRPNAPYRIF--------- 379 G + WGLD + + G E P R + Sbjct: 189 --GADIKFDKWGLDVVFSSSQKAFGVPPGLAIGAFSERFLEIAEKMPERGWYFDIPLYVK 246 Query: 380 ------NTWLGDPSKNLLLAEV-INIIK----REDLLSNAAHAGKVLLTGLLDLQARYPQ 428 +T P + V + II+ +E L K++ G+ ++ Sbjct: 247 YLKEKESTPSTPPMPQVFGINVALRIIEKMGGKEKWLEMYEKRAKMVREGVREIGLDILA 306 Query: 429 FISRVRGRGTFCSFDTPDESIRNKLISIARNKGVML----GGCGDKSIRFRPTLVFRDHH 484 T + TP +++ R +G L G +K+ R + Sbjct: 307 EPG--HESPTITAVLTPPGIKGDEVYEAMRKRGFELAKGYGSVKEKTFRIGHMGYMKFED 364 Query: 485 AHLFLNIFSDILADFK 500 L+ +++ + K Sbjct: 365 IQEMLDNLREVINELK 380 >4LF1-A nrPDB Length = 481 Score = 33.5 bits (75), Expect = 0.22, Method: Composition-based stats. Identities = 13/124 (10%), Positives = 37/124 (29%), Gaps = 3/124 (2%) Query: 111 ALVKLVQQPQNVSTFINRPALGILPPENFVEKLR--ESLLSVAPKGMSQLITMACGSCSN 168 A+ +++ Q+ + + I +++ E L E +L + + G + Sbjct: 231 AVADAMRRAQDKTGEAKLFSFNITADDHY-EMLARGEFILETFADNADHIAFLVDGYVAG 289 Query: 169 ENAFKTIFMWYRSKERGQSAFSKEELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATT 228 A T + + + + + S ++ + G G + Sbjct: 290 PAAVTTARRAFPKQYLHYHRAGHGAVTSPQSKRGYTAFVLSKMARLQGASGIHTGTMGFG 349 Query: 229 HSKA 232 + Sbjct: 350 KMEG 353 >5HH9-A nrPDB Length = 390 Score = 33.1 bits (74), Expect = 0.26, Method: Composition-based stats. Identities = 31/234 (13%), Positives = 70/234 (29%), Gaps = 40/234 (17%) Query: 295 IQSEGGDNHASDDFFRKLRDISRKHG----CAFLVDEVQTGGGSTGKFWA---HEHW--- 344 +QS G + + +R++++K ++VD V G G +A +++ Sbjct: 166 VQSGSGVKLPIREIGKLVRELNQKRDEQDRIIYVVDGVH-GFGVEDVSFADFDCDYFIAG 224 Query: 345 ------GLDDPADVMTFSKKMMTGGFFHKEEFRPNAPYRIFNTWLG-----DPSKNLLLA 393 G ++ S+++ F + T G Sbjct: 225 THKWLFGPRGTGVIIARSEQLQEHLVPSIPTFSRADNFGTLMTPGGYHAFEHRLALGTAF 284 Query: 394 EVINIIKREDLLSNAAHAGKVLLTGLLDLQARYPQFISRVRGR-------GTFCSFDTPD 446 E+ + + ++ + L L +P +VR + +F + Sbjct: 285 ELHLQLGKAEVQARIHQLNAYLKQRL----GEHP----KVRLVTPTSPELSSGFTFFRVE 336 Query: 447 ESIRNKLISIARNKGVM---LGGCGDKSIRFRPTLVFRDHHAHLFLNIFSDILA 497 + V+ + +R P+L+ + L I + LA Sbjct: 337 GRDCEAVAKHLMAHRVISDAVDRDVGPVVRLAPSLLNDEAEIDRVLEILAPQLA 390 >3I4K-A nrPDB Length = 383 Score = 33.1 bits (74), Expect = 0.32, Method: Composition-based stats. Identities = 22/110 (20%), Positives = 33/110 (30%), Gaps = 19/110 (17%) Query: 294 PIQSEGGD----NHASDDFFRKLRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLD-- 347 PI +E G D LR+I+R+ + + DE + E + Sbjct: 215 PILAEAGVELFEQPTPADDLETLREITRRTNVSVMADESV--------WTPAEALAVVKA 266 Query: 348 DPADVMTFSKKMMTGGFFHKEEFRPNAPYR----IFNTWLGDPSKNLLLA 393 ADV+ K GG ++ A T L P Sbjct: 267 QAADVIAL-KTTKHGGLLESKKIAAIAEAGGLACHGATSLEGPIGTAASL 315 >4MY5-A nrPDB Length = 393 Score = 32.8 bits (73), Expect = 0.33, Method: Composition-based stats. Identities = 28/174 (16%), Positives = 52/174 (29%), Gaps = 9/174 (5%) Query: 166 CSNENAFKTIFMWYRSKERGQSAFSKEELETCMINQAPGCPDYSILSFMGAFHGRTMGCL 225 + + A Y + PD IL +GA L Sbjct: 52 EAAKRAIDADESHYTGMAGLLALRQAASAFVKEKYHLTYNPDNEILVTIGA-----TEAL 106 Query: 226 ATTHSKAIHKIDIPSFDWPIAP-FPRLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKK 284 + + + + D P P + + + V E + E L K+ Sbjct: 107 SASLTAILEPGDKVLLPAPAYPGYEPVVNLVGAEVVEIDTRSNDFVLTPEMLEEAILKEG 166 Query: 285 KTVAGIIVE-PIQSEGGDNHASDDFFRKLRDISRKHGCAFLVDEVQTGGGSTGK 337 + + +I+ P G S + L ++ +K+ + DEV TG+ Sbjct: 167 EALKAVILNYPTNPTG--VTYSRQQIKNLAEVLKKYPIFVISDEVYAELTYTGE 218 >1B85-A nrPDB Length = 351 Score = 32.8 bits (73), Expect = 0.36, Method: Composition-based stats. Identities = 25/157 (15%), Positives = 48/157 (30%), Gaps = 22/157 (14%) Query: 163 CGSCSNEN---------AFKTIFMWYRSKERGQSAFSKEELETCMINQAPGCPDYSILSF 213 CG+ ++E+ A G + S + P I+ Sbjct: 41 CGAEAHESIRLVFHDSIAISPAMEAQGKFGGGGADGSIMIFDDIETAFHPNIGLDEIVKL 100 Query: 214 MGAF---HGRT-------MGCLATTHSKAIHKIDIPSFDWPI-APFPRLKYPLEEFVKEN 262 F HG T G +A ++ +++ + P P P P + Sbjct: 101 QKPFVQKHGVTPGDFIAFAGAVALSNCPGAPQMNFFTGRAPATQPAPDGLVPEPFHTVDQ 160 Query: 263 QQEEARCLEEVEDLIVKYRKKKKTVAGII-VEP-IQS 297 E ++L + + +VA + V+P +Q Sbjct: 161 IINRVNDAGEFDELELVFMLSAHSVAAVNDVDPTVQG 197 >4EXQ-A nrPDB Length = 368 Score = 32.4 bits (72), Expect = 0.44, Method: Composition-based stats. Identities = 14/93 (15%), Positives = 30/93 (32%), Gaps = 11/93 (11%) Query: 74 FCNYEESRGNYLVD--VDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPAL 131 + + G +L D G +D ++ +G + + V N+ P + Sbjct: 255 AIAFTKGGGLWLEDLAATG---VDAVGLDWTVNLGRARERVAGRVALQGNLD-----PTI 306 Query: 132 GILPPENFVEKLRESLLSVAPKGMSQLITMACG 164 PPE + ++L + + G Sbjct: 307 LFAPPEAIRAE-ARAVLDSYGNHPGHVFNLGHG 338 >3L8A-A nrPDB Length = 421 Score = 32.4 bits (72), Expect = 0.50, Method: Composition-based stats. Identities = 6/20 (30%), Positives = 12/20 (60%) Query: 309 FRKLRDISRKHGCAFLVDEV 328 K+ ++ +KHG + DE+ Sbjct: 216 LIKIAELCKKHGVILVSDEI 235 >6ONN-A nrPDB Length = 402 Score = 32.0 bits (71), Expect = 0.56, Method: Composition-based stats. Identities = 27/163 (16%), Positives = 47/163 (28%), Gaps = 17/163 (10%) Query: 271 EEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDISRKHGCAFLVDEVQT 330 + E L V I+ + + S GD +L +++ HG +VD+ Sbjct: 165 ADAEALGAMLEASDAAVKLIVSDTVFSMDGDIAP----LARLLELAEHHGAWLVVDDAH- 219 Query: 331 GGGSTGKFW-AHEHWGLDDPADVM---TFSKKMMTGGFFHKE-----EFRPNAPYRIFNT 381 G G G ++ T K G F E+ T Sbjct: 220 GFGVLGPQGRGAVAEAALRSPHLIVVGTLGKAAGVSGAFVVAHETVIEWLVQRARPYIFT 279 Query: 382 WLGDPSKNLLLAEVINII---KREDLLSNAAHAGKVLLTGLLD 421 PS ++ + II + E ++ + L Sbjct: 280 TASVPSAAHAVSASLRIIGGDEGEHRRAHLRSLIALTRDMLKS 322 >4BMK-A nrPDB Length = 442 Score = 32.0 bits (71), Expect = 0.56, Method: Composition-based stats. Identities = 45/224 (20%), Positives = 79/224 (35%), Gaps = 31/224 (13%) Query: 256 EEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDI 315 ++ E + +E+++ + + K+ + +++E + S GD +++ + Sbjct: 188 QQGNAEIVRFRHNSVEDLDKRLGRLPKEPAKL--VVLEGVYSMLGDIAP----LKEMVAV 241 Query: 316 SRKHGCAFLVDEVQT-GGGSTGKFWAHEHWGLDDPADVM--TFSKKMMT-GGFFHK---- 367 ++KHG LVDE + G +E GL+ D + TFS + T GGF Sbjct: 242 AKKHGAMVLVDEAHSMGFFGPNGRGVYEAQGLEGQIDFVVGTFSASVGTVGGFVVSNHPK 301 Query: 368 --EEFRPNAPYRIFNTWLGDPSKNLLLAEVINII-----KREDLLSNAAHAGKVLLTGLL 420 PY T PS I + KRE L SNA L GL Sbjct: 302 FEAVRLACRPYIF--TASLPPSVVATATTSIRKLMTAHEKRERLWSNARA----LHGGLK 355 Query: 421 DLQARYPQFISRVRGRGTFCSFDTPDESIRNKLISIARNKGVML 464 + R + D+ + + G+ + Sbjct: 356 AMGFRLGTETCD----SAIVAVMLEDQEQAAMMWQALLDGGLYV 395 >3DZZ-A nrPDB Length = 391 Score = 32.0 bits (71), Expect = 0.57, Method: Composition-based stats. Identities = 5/24 (20%), Positives = 14/24 (58%) Query: 305 SDDFFRKLRDISRKHGCAFLVDEV 328 S++ +++ ++ KH + DE+ Sbjct: 178 SEEEVKRIAELCAKHQVLLISDEI 201 >3F9T-A nrPDB Length = 397 Score = 31.6 bits (70), Expect = 0.78, Method: Composition-based stats. Identities = 54/357 (15%), Positives = 105/357 (29%), Gaps = 76/357 (21%) Query: 161 MACGSCSNENAFKTIFMWYRSKERGQSAFSKEELETCMINQAPGCPDYSILSFMGAFHGR 220 ++ G+ +N A + I +R K R + ++ I GR Sbjct: 92 VSGGTEANLMALRCIKNIWREKRRKGLSKNEHPKIIVPITAHFSFEK-----------GR 140 Query: 221 TMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFVKENQQEEARCLEEVEDLIVKY 280 M + + A K D + D Y ++ + E ++ +E+L Sbjct: 141 EM--MDLEYIYAPIKED-YTIDEKFVKDAVEDYDVDGIIGIAGTTELGTIDNIEELSKIA 197 Query: 281 RKKKKTV---AGIIVEPIQSEGGDNHASDDFFRKLRDISRKHGCAFLVDEVQTGGGSTGK 337 ++ + A GG F D +K G + D Sbjct: 198 KENNIYIHVDAAF--------GGLVIP---FLD---DKYKKKGVNYKFD----------- 232 Query: 338 FWAHEHWGLDDPADVMTFSKKMMTGGFFHKEE-----FRPNAPY-------RIFNT---W 382 ++ + M + +GG K+ +APY I T + Sbjct: 233 -FSLGVDSITIDPHKMGHC-PIPSGGILFKDIGYKRYLDVDAPYLTETRQATILGTRVGF 290 Query: 383 LGDPSKNLLLAEVINIIKRED---LLSNAAHAGKVLLTGLLDLQARYPQFISRVRGRGTF 439 G V+ + RE +++ L L + + I + Sbjct: 291 GG-----ACTYAVLRYLGREGQRKIVNECMENTLYLYKKLKE--NNFKPVIEPI-----L 338 Query: 440 CSFDTPDESIRNKLISIARNKGVMLGGCG-DKSIRFRPTLVFRDHHAHLFLNIFSDI 495 DE ++ R++G+ + C K++R + H F+ I + I Sbjct: 339 NIVAIEDEDY-KEVCKKLRDRGIYVSVCNCVKALRIVVMPHIKREHIDNFIEILNSI 394 >3B1C-A nrPDB Length = 392 Score = 31.6 bits (70), Expect = 0.80, Method: Composition-based stats. Identities = 9/55 (16%), Positives = 19/55 (34%), Gaps = 5/55 (9%) Query: 309 FRKLRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGL-DDPADVMTFSKKMMTG 362 ++ + +KH + DE+ + HEH D F+ + + Sbjct: 186 LEQIGHLCQKHHVILVSDEIHQDL----TLFGHEHVSFNTVSPDFKDFALVLSSA 236 >2HUU-A nrPDB Length = 393 Score = 31.2 bits (69), Expect = 1.00, Method: Composition-based stats. Identities = 8/58 (13%), Positives = 16/58 (27%), Gaps = 7/58 (12%) Query: 309 FRKLRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGFFH 366 + + +H C +VD V + + D M + + G Sbjct: 163 LEGVGALCHQHNCLLIVDTVAS-------LGGAPMFMDRWEIDAMYTGSQKVLGAPPG 213 >3LWS-A nrPDB Length = 357 Score = 30.8 bits (68), Expect = 1.3, Method: Composition-based stats. Identities = 18/105 (17%), Positives = 37/105 (35%), Gaps = 1/105 (0%) Query: 223 GCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFVKENQQEEARCLEEVEDLIVKYRK 282 G +A + I + + P L+ ++ +KE E + + L+ Sbjct: 71 GTMAQQVALRIWSDETDNRTVAYHPLCHLEIHEQDGLKELHPIETILVGAADRLMTLDEI 130 Query: 283 KK-KTVAGIIVEPIQSEGGDNHASDDFFRKLRDISRKHGCAFLVD 326 K +A +++E Q E G + + R+ G +D Sbjct: 131 KALPDIACLLLELPQREIGGVAPAFSELETISRYCRERGIRLHLD 175 >1M6S-A nrPDB Length = 347 Score = 30.8 bits (68), Expect = 1.3, Method: Composition-based stats. Identities = 39/252 (15%), Positives = 70/252 (27%), Gaps = 23/252 (9%) Query: 260 KENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDISRKH 319 + A ++V I + I +E + G + +++ I+++H Sbjct: 106 PVPGKNGAMDPDDVRKAIRPRNIHFPRTSLIAIENTHNRSGGRVVPLENIKEICTIAKEH 165 Query: 320 GCAFLVD-------EVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGFFHKEEFRP 372 G +D + +G E+ G D + SK + Sbjct: 166 GINVHIDGARIFNASIASGVP------VKEYAGYADSV-MFCLSKGL--CAPVGSVVVGD 216 Query: 373 ---NAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDLQA-RYPQ 428 R LG + + II ++ + L L+ Y Sbjct: 217 RDFIERARKARKMLGGGMRQAGVLAAAGIIALTKMVDRLKEDHENARFLALKLKEIGYSV 276 Query: 429 FISRVRGRGTFCSFDTPDESIRNK-LISIARNKGVMLGGCGDKSIRFRPTLVFRDHHAHL 487 V+ T + + I RN GV+ D IR + Sbjct: 277 NPEDVKTN--MVILRTDNLKVNAHGFIEALRNSGVLANAVSDTEIRLVTHKDVSRNDIEE 334 Query: 488 FLNIFSDILADF 499 LNIF + F Sbjct: 335 ALNIFEKLFRKF 346 >3E9K-A nrPDB Length = 465 Score = 30.8 bits (68), Expect = 1.4, Method: Composition-based stats. Identities = 15/70 (21%), Positives = 24/70 (34%), Gaps = 5/70 (7%) Query: 432 RVRGRGTFCSFDTPDESIRNKLISIARNKGVMLGGCGDKSIRFRP-TLVFRDHHAHLFLN 490 RG +F P+ + +GV+ IR P L H + F N Sbjct: 397 EERGCQLTITFSVPN----KDVFQELEKRGVVCDKRNPNGIRVAPVPLYNSFHDVYKFTN 452 Query: 491 IFSDILADFK 500 + + IL + Sbjct: 453 LLTSILDSAE 462 >1LLP-A nrPDB Length = 343 Score = 30.5 bits (67), Expect = 1.7, Method: Composition-based stats. Identities = 25/157 (15%), Positives = 50/157 (31%), Gaps = 22/157 (14%) Query: 163 CGSCSNEN---------AFKTIFMWYRSKERGQSAFSKEELETCMINQAPGCPDYSILSF 213 CG+ ++E+ A G + S +T P +++ Sbjct: 34 CGAEAHESIRLVFHDSIAISPAMEAKGKFGGGGADGSIMIFDTIETAFHPNIGLDEVVAM 93 Query: 214 MGAF---HGRT-------MGCLATTHSKAIHKIDIPSFDWPI-APFPRLKYPLEEFVKEN 262 F HG T G +A ++ +++ + P P P P + Sbjct: 94 QKPFVQKHGVTPGDFIAFAGAVALSNCPGAPQMNFFTGRKPATQPAPDGLVPEPFHTVDQ 153 Query: 263 QQEEARCLEEVEDLIVKYRKKKKTVAGII-VEP-IQS 297 E ++L + + +VA + V+P +Q Sbjct: 154 IIARVNDAGEFDELELVWMLSAHSVAAVNDVDPTVQG 190 >3NL2-A nrPDB Length = 540 Score = 30.5 bits (67), Expect = 1.8, Method: Composition-based stats. Identities = 11/114 (9%), Positives = 32/114 (28%), Gaps = 24/114 (21%) Query: 311 KLRDISRKHGCAFLVD---EVQTGGGSTGKFWAHEHWGLD-----DPADVMTFSKKMMTG 362 +++++ H +++ +V G+ G + + D++ G Sbjct: 60 QIKELCHAHNVPLIINDRIDVAMAIGADGIHVGQDDMPIPMIRKLVGPDMVI---GWSVG 116 Query: 363 GF--------FHKEEFRPNAPYRIFNTWLGD-----PSKNLLLAEVINIIKRED 403 + +F T P V++ ++R + Sbjct: 117 FPEEVDELSKMGPDMVDYIGVGTLFPTLTKKNPKKAPMGTAGAIRVLDALERNN 170 >3KGX-A nrPDB Length = 393 Score = 30.5 bits (67), Expect = 1.8, Method: Composition-based stats. Identities = 11/41 (26%), Positives = 17/41 (41%), Gaps = 6/41 (14%) Query: 295 IQSEG--GDNHASDDFFRKLRDISRKHGCAFLVDEVQTGGG 333 + E G D F ++ ++ C LVD V + GG Sbjct: 155 VHGESSTGVVQPLDGF----GELCHRYQCLLLVDSVASLGG 191 >5BQK-A nrPDB Length = 271 Score = 30.5 bits (67), Expect = 1.9, Method: Composition-based stats. Identities = 21/150 (14%), Positives = 50/150 (33%), Gaps = 16/150 (10%) Query: 325 VDEVQTGGGSTGKF----WAHEHWGLDDPADVMTFSKKMMTGGFFHKEEFR-------PN 373 VD + G + + + + + + + + GG F E R + Sbjct: 21 VDRISESFGRSAQVMHDPFGGQPFPAANSPWAPVLAGQ---GGPFDAETRRVSWETLVAH 77 Query: 374 APYRIFNTWLGDPSKNLLLAEVIN-IIKREDLLSNAAHAGKVLLTGLLDLQARYPQFISR 432 P ++ T+ G+P + + ++++E+ + A A + L + + P Sbjct: 78 GP-SLYRTFAGNPRAASTAKAMRDCVLRQENFIEALASADETLAWCKMCIHHNLPLRPQD 136 Query: 433 VRGRGTFCSFDTPDESIRNKLISIARNKGV 462 D +R L + +G+ Sbjct: 137 PIIGTAAAVLDNLATRLRPFLQCYLKARGL 166 >3WGB-A nrPDB Length = 341 Score = 30.5 bits (67), Expect = 1.9, Method: Composition-based stats. Identities = 31/209 (14%), Positives = 63/209 (30%), Gaps = 20/209 (9%) Query: 298 EGGDNHASDDFFRKLRDISRKHGCAFLVDEVQTGGGST-GKFWAHEHWGLDDPADV---- 352 G + R++R++ +HG +D G A H + A Sbjct: 145 NGKVLPLP--YLREMRELVDEHGLQLHLD-----GARLFNAVVASGHTVRELVAPFDSVS 197 Query: 353 MTFSKKMMTGGFFHKEEFRPN---APYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAA 409 + SK + G + A R +G + + + + + A Sbjct: 198 ICLSKGL--GAPVGSLLVGSHAFIARARRLRKMVGGGMRQAGILAQAGLFALQQHVVRLA 255 Query: 410 HAGKVLLTGLLDLQARYPQFISRVRGRGTFCSFDTPDESIRNKLISIARNKGVMLGGCGD 469 + L + A P + T F L++ + +G++ G G+ Sbjct: 256 DDHRRARQ-LAEGLAALPGIRLDLAQVQTNMVFLQLTSGESAPLLAFMKARGILFSGYGE 314 Query: 470 KSIRFRPTLVFRDHHAHLFLNIFSDILAD 498 +R L D ++ F++ L Sbjct: 315 --LRLVTHLQIHDDDIEEVIDAFTEYLGA 341 >4JO5-A nrPDB Length = 190 Score = 30.1 bits (66), Expect = 2.1, Method: Composition-based stats. Identities = 30/194 (15%), Positives = 62/194 (31%), Gaps = 31/194 (15%) Query: 124 TFINRPALGILPPENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKE 183 T N PA + VE + Q GS + + + T+ +Y Sbjct: 5 TPTNTPANTPVSGNLKVEFYNSNPSDTTNSINPQFKVTNTGSSAIDLSKLTLRYYYTVDG 64 Query: 184 RGQSAFSKEELETCMINQAPGCPDYSILSFMGAFHGR------TMGCLATTHSKAIHKID 237 + F C +I+ G+++G T ++++ + A ++ Sbjct: 65 QKDQTF--------------WCDHAAIIGSNGSYNGITSNVKGTFVKMSSSTNNADTYLE 110 Query: 238 IPSFDWPIAPFPRLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVA---GIIV-- 292 I + P ++ F K + + + ++ + + A G++V Sbjct: 111 ISFTGGTLEPGAHVQIQGR-FAKNDWSNYTQSNDYSFKSASQFVEWDQVTAYLNGVLVWG 169 Query: 293 -EPIQSEGGDNHAS 305 EP GG S Sbjct: 170 KEP----GGSVVPS 179 >1BW0-A nrPDB Length = 416 Score = 30.1 bits (66), Expect = 2.4, Method: Composition-based stats. Identities = 18/139 (12%), Positives = 41/139 (29%), Gaps = 19/139 (13%) Query: 138 NFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELETC 197 ++KL+E++ S G + E + W+R+ + ++ Sbjct: 54 AQIKKLKEAIDSQECNGY---FPTVGSPEAREA----VATWWRNSFVHKEELKSTIVKD- 105 Query: 198 MINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEE 257 +++ G HG M A + + P F + Sbjct: 106 -----------NVVLCSGGSHGILMAITAICDAGDYALVPQPGFPHYETVCKAYGIGMHF 154 Query: 258 FVKENQQEEARCLEEVEDL 276 + + + L+E+ L Sbjct: 155 YNCRPENDWEADLDEIRRL 173 >5VNX-A nrPDB Length = 393 Score = 30.1 bits (66), Expect = 2.4, Method: Composition-based stats. Identities = 15/89 (16%), Positives = 29/89 (32%), Gaps = 6/89 (6%) Query: 87 DVDGNRMLDLYSQISSIPIG-YSHPALVKLVQQPQNVSTFINRPALGILPPENFVEKLRE 145 V+G ++ S +G +HP LV + + + + KL + Sbjct: 35 TVNGREIVGFASNDY---LGLAAHPKLVAAFAEGAQRYGSGSGGSHLLGGHSRAHAKLED 91 Query: 146 SLLSVAPK--GMSQLITMACGSCSNENAF 172 L A + + + G +N A Sbjct: 92 ELAGFAGGFSDAPRALYFSTGYMANLAAV 120 >3ISL-A nrPDB Length = 416 Score = 30.1 bits (66), Expect = 2.5, Method: Composition-based stats. Identities = 25/120 (20%), Positives = 42/120 (35%), Gaps = 16/120 (13%) Query: 222 MGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFVK------ENQQEEARCLEEVED 275 G + + P D I + R Y L E + + E + + ED Sbjct: 68 DGTSRAGIEAVLASVIEPEDDVLIPIYGRFGYLLTEIAERYGANVHMLECEWGTVFDPED 127 Query: 276 LIVKYRKKKKTVAGIIVEPIQSEG--GDNHASDDFFRKLRDISRKHGCAFLVDEVQTGGG 333 +I + +K K + + + E G H + + + R F+VD V T GG Sbjct: 128 IIREIKKVKPKIVAM----VHGETSTGRIHP----LKAIGEACRTEDALFIVDAVATIGG 179 >3UWC-A nrPDB Length = 374 Score = 29.7 bits (65), Expect = 2.7, Method: Composition-based stats. Identities = 23/177 (12%), Positives = 42/177 (23%), Gaps = 14/177 (7%) Query: 170 NAFKTIFMWY-RSKERGQSAFSKEELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATT 228 NA + + + R + + + G A H T Sbjct: 2 NAMRVPYSYLERQFADIEPYLNDLREFIKTADFTLGAELEKFEKRFAALHNAPHAIGVGT 61 Query: 229 HSKAIHKIDIPSFDWPIAPFPRLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVA 288 + A+ A + +A + D Y + + Sbjct: 62 GTDALAMSF--KMLNIGAGDEVITCANTFIASVGAIVQAGATPVLVDSENGYVIDPEKIE 119 Query: 289 GIIVE------PIQSEGGDNHASDDFFRKLRDISRKHGCAFLVDEVQTGGGSTGKFW 339 I + P+ G L I++KH + D QT G + Sbjct: 120 AAITDKTKAIMPVHYTGNIAD-----MPALAKIAKKHNLHIVEDACQTILGRINDKF 171 >2Z1K-A nrPDB Length = 475 Score = 29.7 bits (65), Expect = 2.8, Method: Composition-based stats. Identities = 16/63 (25%), Positives = 28/63 (44%), Gaps = 11/63 (17%) Query: 282 KKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDISRKHGCAFLVDEVQTGGGSTGK-FWA 340 + TV V+PI ++ R L +++ HG ++D V TG+ F+A Sbjct: 79 HRYHTVDYFQVDPILGG-------NEALRHLLEVAHAHGVRVILDGV---FNHTGRGFFA 128 Query: 341 HEH 343 +H Sbjct: 129 FQH 131 >6DEO-A nrPDB Length = 682 Score = 29.7 bits (65), Expect = 3.0, Method: Composition-based stats. Identities = 13/75 (17%), Positives = 25/75 (33%), Gaps = 4/75 (5%) Query: 300 GDNHASDDFFRKLRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKM 359 G +++ D ++ + + V TG G + WA +H+ P ++T Sbjct: 463 GSLIKPQTLIKEISDQAQTYNKEVI---VTTGVGQH-QMWAAQHFTWTQPRTMITSGGLG 518 Query: 360 MTGGFFHKEEFRPNA 374 G A Sbjct: 519 TMGYGLPAAIGAQVA 533 >1VJO-A nrPDB Length = 393 Score = 29.7 bits (65), Expect = 3.3, Method: Composition-based stats. Identities = 22/120 (18%), Positives = 39/120 (32%), Gaps = 14/120 (11%) Query: 219 GRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFVKE-----NQQEEARCLEEV 273 G + T + A+ D+ RL + + E LEE+ Sbjct: 92 GTGTAAMEATIANAVEPGDVVLIGVAGYFGNRLVDMAGRYGADVRTISKPWGEVFSLEEL 151 Query: 274 EDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDISRKHGCAFLVDEVQTGGG 333 + +R +A + E + G + ++ R+ G LVD V + GG Sbjct: 152 RTALETHR--PAILALVHAE---TSTGARQP----LEGVGELCREFGTLLLVDTVTSLGG 202 >2ZJG-A nrPDB Length = 410 Score = 29.7 bits (65), Expect = 3.4, Method: Composition-based stats. Identities = 6/20 (30%), Positives = 10/20 (50%) Query: 309 FRKLRDISRKHGCAFLVDEV 328 + + D+ KH + DEV Sbjct: 189 LQVIADLCVKHDTLCISDEV 208 >2EZ4-A nrPDB Length = 603 Score = 29.7 bits (65), Expect = 3.4, Method: Composition-based stats. Identities = 19/118 (16%), Positives = 41/118 (34%), Gaps = 3/118 (2%) Query: 178 WYRSKERGQSAFSKEELETCMINQAPGCPDYSILS-FMGAFHGRTMGCLATTHSKAIHKI 236 +Y R ++ +T I P I++ A+ G ++A+ + Sbjct: 218 YYGIGARKAGKELEQLSKTLKIPLMSTYPAKGIVADRYPAYLGSANRVAQKPANEALAQA 277 Query: 237 DIPSFDWPIAPFPRLKYPL--EEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIV 292 D+ F PF + + + + A+ + + I +KT+A I+ Sbjct: 278 DVVLFVGNNYPFAEVSKAFKNTRYFLQIDIDPAKLGKRHKTDIAVLADAQKTLAAILA 335 >1P0K-A nrPDB Length = 349 Score = 29.3 bits (64), Expect = 3.8, Method: Composition-based stats. Identities = 14/91 (15%), Positives = 23/91 (25%), Gaps = 9/91 (9%) Query: 307 DFFRKLRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGFFH 366 +++ I + +V EV G G + + D+ F Sbjct: 165 GALKRIEQICSRVSVPVIVKEV--GFGMSKASAGKLYEAGAAAVDI----GGYGGTNFSK 218 Query: 367 KEEFRPNAPYRIFNTWLGDPSKNLLLAEVIN 397 E R FN+W I Sbjct: 219 IENLRRQRQISFFNSWG---ISTAASLAEIR 246 >4QR8-A nrPDB Length = 443 Score = 29.3 bits (64), Expect = 3.9, Method: Composition-based stats. Identities = 19/124 (15%), Positives = 36/124 (29%), Gaps = 14/124 (11%) Query: 108 SHPALVKLVQQPQ-----NVSTFINRPALGILPPENFVEKLRE--------SLLSVAPKG 154 H A + + N++ P + + L E L AP+ Sbjct: 180 GHRAAEEAFRSGMSEFDINIAYLTATGHRDTDVPYSNIVALNEHAAVLHYTKLDHQAPEE 239 Query: 155 MSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELETCMINQAPGCPDYSILSFM 214 M + + G+ N A W + + K+ + + A S + + Sbjct: 240 M-RSFLLDAGAEYNGYAADLTRTWSAKSDNDYAQLVKDVNDEQLALIATMKAGVSYVDYH 298 Query: 215 GAFH 218 FH Sbjct: 299 IQFH 302 >2RUS-A nrPDB Length = 490 Score = 29.3 bits (64), Expect = 4.5, Method: Composition-based stats. Identities = 10/123 (8%), Positives = 35/123 (28%), Gaps = 3/123 (2%) Query: 112 LVKLVQQPQNVS--TFINRPALGILPPENFVEKLRESLLSVAPKGMSQLITMACGSCSNE 169 + +++ Q+ + + + P + + E +L + S + + G + Sbjct: 235 VADAMRRAQDETGEAKLFSANITADDPFEIIAR-GEYVLETFGENASHVALLVDGYVAGA 293 Query: 170 NAFKTIFMWYRSKERGQSAFSKEELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTH 229 A T + + + + + ++ + G G + Sbjct: 294 AAITTARRRFPDNFLHYHRAGHGAVTSPQSKRGYTAFVHCKMARLQGASGIHTGTMGFGK 353 Query: 230 SKA 232 + Sbjct: 354 MEG 356 >1D4E-A nrPDB Length = 572 Score = 29.3 bits (64), Expect = 4.6, Method: Composition-based stats. Identities = 13/138 (9%), Positives = 37/138 (26%), Gaps = 6/138 (4%) Query: 174 TIFMWYRSKERGQSAFSKEELETCMINQAPGCPDYSILSFMGAFHG----RTMGCLATTH 229 + + + + + ++ A G ++ G + G + + Sbjct: 257 VAQVLWDNAVKRGTDIRLNSRVVRILEDASGKVTGVLVK--GEYTGYYVIKADAVVIAAG 314 Query: 230 SKAIHKIDIPSFDWPIAPFPRLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAG 289 A + + +D + F +P + +A I + Sbjct: 315 GFAKNNERVSKYDPKLKGFKATNHPGATGDGLDVALQAGAATRDLQYIQAHPTYSPAGGV 374 Query: 290 IIVEPIQSEGGDNHASDD 307 +I E ++ G + Sbjct: 375 MITEAVRGNGAIVVNREG 392 >1O89-A nrPDB Length = 345 Score = 28.9 bits (63), Expect = 5.0, Method: Composition-based stats. Identities = 11/50 (22%), Positives = 14/50 (28%) Query: 403 DLLSNAAHAGKVLLTGLLDLQARYPQFISRVRGRGTFCSFDTPDESIRNK 452 L A G L+ L AR I C D +R + Sbjct: 118 GLAEQARVKGDWLVAMPQGLDARKAMIIGTAGFTAMLCVMALEDAGVRPQ 167 >3KE3-A nrPDB Length = 379 Score = 28.9 bits (63), Expect = 5.0, Method: Composition-based stats. Identities = 11/58 (18%), Positives = 27/58 (46%), Gaps = 2/58 (3%) Query: 275 DLIVKYRKKKKTVAGIIVEP-IQSEGGDNHASDDFFRKLRDISRKHGCAFLVDEVQTG 331 D+ K K+ + I+ P +++ G S+++ + L + G ++D + +G Sbjct: 123 DIETAVAKIKEDKSAIVYAPHVETSSGIIL-SEEYIKALSEAVHSVGGLLVIDCIASG 179 >1GDE-A nrPDB Length = 389 Score = 28.9 bits (63), Expect = 5.2, Method: Composition-based stats. Identities = 29/158 (18%), Positives = 43/158 (27%), Gaps = 7/158 (4%) Query: 171 AFKTIFMWYRSKERGQSAFSKEELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHS 230 A Y + N P I+ +GA MG A Sbjct: 51 ALDKGLTHYGPNIGLLELREAIAEKLKKQNGIEADPKTEIMVLLGANQAFLMGLSAFLKD 110 Query: 231 KAIHKIDIPSFDWPIAPFPRLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGI 290 I P+F E + E ++E++ + KT A I Sbjct: 111 GEEVLIPTPAFVSYAPAVILAGGKPVEVPTYEEDEFRLNVDELKKYVT-----DKTRALI 165 Query: 291 IVEPIQSEGGDNHASDDFFRKLRDISRKHGCAFLVDEV 328 I P G D ++ D +H + DEV Sbjct: 166 INSPCNPTGAVLTKKD--LEEIADFVVEHDLIVISDEV 201 >6E14-D nrPDB Length = 879 Score = 28.9 bits (63), Expect = 5.7, Method: Composition-based stats. Identities = 13/71 (18%), Positives = 23/71 (32%), Gaps = 5/71 (7%) Query: 94 LDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGILPPENFVEKLRESLLSVAPK 153 L+ + IGYSH +K + + + + + P N L + AP Sbjct: 671 LNYRGGYGNANIGYSHSDDIKQLYYGVSGGVLAHANGVTLGQPLNDTVVLVK-----APG 725 Query: 154 GMSQLITMACG 164 + G Sbjct: 726 AKDAKVENQTG 736 >1YDM-A nrPDB Length = 187 Score = 28.9 bits (63), Expect = 5.7, Method: Composition-based stats. Identities = 17/98 (17%), Positives = 32/98 (32%), Gaps = 13/98 (13%) Query: 393 AEVINIIKREDLLSNAAHAGKVLLTGLLDLQARYPQFISRVRGRGTFCSFDTPDESIRNK 452 E ++ + ED+L K L + L + Q ++ RG + P Sbjct: 10 LEALSALSNEDILQKTERMYKYLFS-LPEWQNAGTIAVTISRG------LEIP----TRP 58 Query: 453 LISIARNKG--VMLGGCGDKSIRFRPTLVFRDHHAHLF 488 +I A +G V + C + + + D Sbjct: 59 VIEQAWEEGKQVCIPKCHPDTKKMQFRTYQTDDQLETV 96 >1D2F-A nrPDB Length = 390 Score = 28.9 bits (63), Expect = 5.9, Method: Composition-based stats. Identities = 5/20 (25%), Positives = 10/20 (50%) Query: 309 FRKLRDISRKHGCAFLVDEV 328 + D+ +HG + DE+ Sbjct: 184 LEIMADLCERHGVRVISDEI 203 >2YRI-A nrPDB Length = 353 Score = 28.5 bits (62), Expect = 6.6, Method: Composition-based stats. Identities = 31/218 (14%), Positives = 67/218 (30%), Gaps = 28/218 (12%) Query: 300 GDNHASDDFFRKLRDISRKHGCAFLVDEVQT---------GGGSTGKFWAHEHWGLDDPA 350 G + + + ++++ G F +D V T G F + L P Sbjct: 138 GVLNPA----EAIGALAKEAGALFFLDAVTTLGMLPFSMRAMGVDYAFTGSQK-CLSAPP 192 Query: 351 DVMTFS------KKMMTGGFFHKEEFRPNAPYRIFNTWLGDPSKN-LLLAEVINIIKRED 403 + + K ++ + R + P L E ++++ E Sbjct: 193 GLAPIAASLEARKAFTGKRGWYLDLARVAEHWERGGYHHTTPVLLHYALLEALDLVLEEG 252 Query: 404 LLSNAAHAGKVLLTGLLDLQARYPQFISRVRGRGTFCSFDTPDESIRNKLISIARNKGVM 463 + + A +V L +L+AR + + T P+ ++L+ +GV Sbjct: 253 VAARERRAREVYAWVLEELKARGFRPYPKASPLPTVLVVRPPEGVDADRLVRALYAEGVA 312 Query: 464 ----LGGCGDKSIRFRPTLVFRDHHAHLFLNIFSDILA 497 +G + +R + + F L Sbjct: 313 VAGGIGPTRGQVLRLG---LMGEGARREAYQAFLKALD 347 >5W4C-A nrPDB Length = 371 Score = 28.5 bits (62), Expect = 6.8, Method: Composition-based stats. Identities = 17/90 (18%), Positives = 28/90 (31%), Gaps = 2/90 (2%) Query: 371 RPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDLQARYPQFI 430 + I + G + L + + E +L+N G L T +P F Sbjct: 29 MHSKVVIIGSGPGGHTAAIYLARANLEPVLYEGMLANGFAPGGQLTTTTD--VENFPGFP 86 Query: 431 SRVRGRGTFCSFDTPDESIRNKLISIARNK 460 V G F E K+I+ + Sbjct: 87 EGVTGTEMMDKFRAQSERFGTKIITETVAR 116 >2FQL-A nrPDB Length = 123 Score = 28.5 bits (62), Expect = 7.0, Method: Composition-based stats. Identities = 10/45 (22%), Positives = 14/45 (31%) Query: 402 EDLLSNAAHAGKVLLTGLLDLQARYPQFISRVRGRGTFCSFDTPD 446 E A LL L +L +P I V + + P Sbjct: 20 EKAHEEADDYLDHLLDSLEELSEAHPDCIPDVELSHGVMTLEIPA 64 >4EB7-A nrPDB Length = 382 Score = 28.5 bits (62), Expect = 7.1, Method: Composition-based stats. Identities = 11/96 (11%), Positives = 28/96 (29%), Gaps = 11/96 (11%) Query: 93 MLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGILP---PENFVEKLRESLLS 149 D S +++ + ++ P+ V++ RE + Sbjct: 3 YFDYTSAKPV------DERILEAM--LPYMTESFGNPSSVHSYGFKAREAVQEAREKVAK 54 Query: 150 VAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERG 185 + G ++ + + +N A M K + Sbjct: 55 LVNGGGGTVVFTSGATEANNLAIIGYAMRNARKGKH 90 >5EJJ-A nrPDB Length = 564 Score = 28.5 bits (62), Expect = 7.2, Method: Composition-based stats. Identities = 16/114 (14%), Positives = 30/114 (26%), Gaps = 8/114 (7%) Query: 108 SHPALVKL-VQQPQNVSTFINRPALGILPPENFVEKLRESLLSVAPKGMSQLITMACGSC 166 SH + + V + F+ +FV L E L K + I G+ Sbjct: 420 SHREIQQALVDIQDKQAKFVGSRQWIGSTEISFV--LNELL-----KLECRFIATNSGAE 472 Query: 167 SNENAFKTIFMWYRSKERGQSAFSKEELETCMINQAPGCPDYSILSFMGAFHGR 220 E + + S + ++ + L + G Sbjct: 473 VVERVRELARHFETSGTPVMIGGNMLAHTILGVDFNDTTGETKFLVLDPHYTGS 526 >2ZYJ-A nrPDB Length = 397 Score = 28.5 bits (62), Expect = 7.8, Method: Composition-based stats. Identities = 45/350 (12%), Positives = 91/350 (26%), Gaps = 39/350 (11%) Query: 172 FKTIFMWYRSKERGQSAFSKEELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSK 231 + + + L + P+ ++ T G Sbjct: 57 ARILREKGEVALQYSPTEGYAPLRAFVAEWIGVRPEEVLI---------TTGSQQALDLV 107 Query: 232 AIHKIDIPSFDWPIAP-----FPRLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKT 286 +D S AP + F+ EE L+ +E+++ + R + Sbjct: 108 GKVFLDEGSPVLLEAPSYMGAIQAFRLQGPRFLTVPAGEEGPDLDALEEVLKRERPRFLY 167 Query: 287 VAGIIVEPIQSEGGDNHASDDFFRKLRDISRKHGCAFLVD----EVQTGGGSTGKFWAHE 342 + P GG ++L + + G + D E+ G + Sbjct: 168 LIPSFQNP---TGGLTPLPAR--KRLLQMVMERGLVVVEDDAYRELYFGEARLPSLFELA 222 Query: 343 HWGLDDPADVM-TFSKKMMTGGFFHKEEFRPNAPYRIFNTWLGDPSKNLLLAEVI-NIIK 400 + +FSK + G P A ++ G +L +++ + + Sbjct: 223 REAGYPGVIYLGSFSKVLSPGLRVAFAVAHPEALQKLVQAKQGADLHTPMLNQMLVHELL 282 Query: 401 REDLLSNAAHAGKVLLTG----LLDLQARYPQFISRVRGR-GTFCSFDTPDESIRNKLIS 455 +E +V L L P+ + R + G F + P L Sbjct: 283 KEGFSERLERVRRVYREKAQAMLHALDREVPKEVRYTRPKGGMFVWMELPKGLSAEGLFR 342 Query: 456 IARNKGVMLGGCGD--------KSIRFRPTLVFRDHHAHLFLNIFSDILA 497 A + V G ++R + L Sbjct: 343 RALEENVAFVPGGPFFANGGGENTLRLSYA-TLDREGIAEGVRRLGRALK 391 >4CVQ-A nrPDB Length = 431 Score = 28.1 bits (61), Expect = 9.4, Method: Composition-based stats. Identities = 29/176 (16%), Positives = 57/176 (32%), Gaps = 34/176 (19%) Query: 248 FPRLKYPLEEFV---------KENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSE 298 P YPL E + +++D+ K + + + +I+ P Sbjct: 150 VPAPDYPLWTAAVSLSSGKAVHYLCDESSDWFPDLDDIRAKITPRTRGI--VIINPNNPT 207 Query: 299 GGDNHASDDFFRKLRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDD-PADVMT--- 354 G S + ++ +I+R+H DE+ + EH + D++T Sbjct: 208 GAV--YSKELLMEIVEIARQHNLIIFADEIYDKI----LYDDAEHHSIAPLAPDLLTITF 261 Query: 355 --FSKKMMTGGFFHKEEFRPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNA 408 SK GF + N P + + E + ++ L +N Sbjct: 262 NGLSKTYRVAGF-RQGWMVLNGPKKHAKGY----------IEGLEMLASMRLCANV 306 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.313 0.131 0.357 Lambda K H 0.267 0.0404 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 19,438,756 Number of Sequences: 36641 Number of extensions: 814610 Number of successful extensions: 3604 Number of sequences better than 10.0: 166 Number of HSP's better than 10.0 without gapping: 186 Number of HSP's successfully gapped in prelim test: 67 Number of HSP's that attempted gapping in prelim test: 2744 Number of HSP's gapped (non-prelim): 312 length of query: 500 length of database: 10,336,785 effective HSP length: 101 effective length of query: 399 effective length of database: 6,636,044 effective search space: 2647781556 effective search space used: 2647781556 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.4 bits) S2: 61 (28.1 bits)