BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P69924 (376 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 1PIY-A nrPDB 780 0.0 2RCC-A nrPDB 93 2e-19 4M1I-A nrPDB 83 2e-16 3DHZ-A nrPDB 82 5e-16 3MJO-A nrPDB 82 5e-16 1UZR-A nrPDB 80 2e-15 4BMQ-A nrPDB 79 3e-15 2BQ1-I nrPDB 74 2e-13 3N37-A nrPDB 70 2e-12 4DR0-A nrPDB 69 3e-12 1H0O-A nrPDB 69 5e-12 4DJN-A nrPDB 67 1e-11 6GP2-A nrPDB 67 2e-11 3HF1-A nrPDB 67 2e-11 4N83-A nrPDB 66 3e-11 3OLJ-A nrPDB 65 6e-11 1SMQ-A nrPDB 62 3e-10 2UW2-A nrPDB 62 5e-10 2O1Z-A nrPDB 61 9e-10 2P1I-A nrPDB 60 1e-09 6EBP-A nrPDB 59 2e-09 6QRZ-A nrPDB 37 0.012 5OLK-A nrPDB 34 0.10 1SMS-A nrPDB 33 0.20 3CNZ-A nrPDB 33 0.25 4AC8-A nrPDB 32 0.45 3H4S-A nrPDB 30 1.4 4V0B-A nrPDB 29 2.6 5EIX-A nrPDB 28 5.9 4ZRX-A nrPDB 28 7.2 3VB0-A nrPDB 28 7.4 6D6K-A nrPDB 28 7.9 3WPN-A nrPDB 28 8.2 4HGN-A nrPDB 28 8.4 >1PIY-A nrPDB Length = 375 Score = 780 bits (2014), Expect = 0.0, Method: Compositional matrix adjust. Identities = 374/375 (99%), Positives = 374/375 (99%) Query: 2 AYTTFSQTKNDQLKEPMFFGQPVNVARYDQQKYDIFEKLIEKQLSFFWRPEEVDVSRDRI 61 AYTTFSQTKNDQLKEPMFFGQPVNVARYDQQKYDIFEKLIEKQLSFFWRPEEVDVSRDRI Sbjct: 1 AYTTFSQTKNDQLKEPMFFGQPVNVARYDQQKYDIFEKLIEKQLSFFWRPEEVDVSRDRI 60 Query: 62 DYQALPEHEKHIFISNLKYQTLLDSIQGRSPNVALLPLISIPELETWVETWAFSETIHSR 121 DYQALPEHEKHIFISNLKYQTLLDSIQGRSPNVALLPLISIPELETWVETWAFSETIHSR Sbjct: 61 DYQALPEHEKHIFISNLKYQTLLDSIQGRSPNVALLPLISIPELETWVETWAFSETIHSR 120 Query: 122 SYTHIIRNIVNDPSVVFDDIVTNEQIQKRAEGISSYYDELIEMTSYWHLLGEGTHTVNGK 181 SYTHIIRNIVNDPSVVFDDIVTNEQIQKRAEGISSYYDELIEMTSYWHLLGEGTHTVNGK Sbjct: 121 SYTHIIRNIVNDPSVVFDDIVTNEQIQKRAEGISSYYDELIEMTSYWHLLGEGTHTVNGK 180 Query: 182 TVTVSLRELKKKLYLCLMSVNALEAIRFYVSFACSFAFAERELMEGNAKIIRLIARDEAL 241 TVTVSLRELKKKLYLCLMSVNALEAIRFYVSFACSFAFAERELMEGNAKIIRLIARDEAL Sbjct: 181 TVTVSLRELKKKLYLCLMSVNALEAIRFYVSFACSFAFAERELMEGNAKIIRLIARDEAL 240 Query: 242 HLTGTQHMLNLLRSGADDPEMAEIAEECKQECYDLFVQAAQQEKDWADYLFRDGSMIGLN 301 HLTGTQHMLNLLRSGADDPEMAEIAEECKQECYDLFVQAAQQEKDWADYLFRDGSMIGLN Sbjct: 241 HLTGTQHMLNLLRSGADDPEMAEIAEECKQECYDLFVQAAQQEKDWADYLFRDGSMIGLN 300 Query: 302 KDILCQYVEYITNIRMQAVGLDLPFQTRSNPIPWINTWLVSDNVQVAPQEVEVSSYLVGQ 361 KDILCQYVEYITNIRMQAVGLDLPF TRSNPIPWINTWLVSDNVQVAPQEVEVSSYLVGQ Sbjct: 301 KDILCQYVEYITNIRMQAVGLDLPFNTRSNPIPWINTWLVSDNVQVAPQEVEVSSYLVGQ 360 Query: 362 IDSEVDTDDLSNFQL 376 IDSEVDTDDLSNFQL Sbjct: 361 IDSEVDTDDLSNFQL 375 >2RCC-A nrPDB Length = 346 Score = 92.8 bits (229), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 77/324 (23%), Positives = 144/324 (44%), Gaps = 37/324 (11%) Query: 21 GQPVNVARYDQQKYDIFEKLIEKQLSFFWRPEEVDVSRDRIDYQALPEHEKHIFISNLKY 80 G+ NV +D ++ L + L+ FW P E+++S D + L E E+ F + Sbjct: 25 GKSSNVLNWDDVRFSWAYPLYKNMLANFWTPFEINMSHDAKQFPTLTETEQEAFKKIIGL 84 Query: 81 QTLLDSIQGRSPNVALLPLISIPELETWVETWAFSETIHSRSYTHIIRNIVNDPSVVFDD 140 LDS+Q ++ ++ L + +F E +H++SY++++ ++V P D+ Sbjct: 85 LAFLDSVQ-TDYSMRAAEYLTDSSLAALMSVLSFQEVVHNQSYSYVLSSLV--PKATQDE 141 Query: 141 IVT----NEQIQKRAEGISSYYDELIEMTSYWHLLGEGTHTVNGKTVTVSLRELKKKLYL 196 I ++ +++R E I Y++ ++ + L + V Sbjct: 142 IFEYWKHDDVLKERNEFIIDGYEKFVDNPTPKTFLESIVYDV------------------ 183 Query: 197 CLMSVNALEAIRFYVSFACSFAFAERELMEGNAKIIRLIARDEALHLTGTQHMLNLLRSG 256 LE + FY FA + A + M + +I I RDE LH+ ++ L Sbjct: 184 ------ILEGLNFYSGFAFFYNLARNQKMVSTSTMINYINRDEQLHVYLFTNIFKELL-- 235 Query: 257 ADDPEMAEIAEECKQECYDLFVQAAQQEKDWADYLFRDGSMIGLNKDILCQYVEYITNIR 316 + PE+ EE K ++AA EKDW Y+ D + G+N + + Y+ +I N R Sbjct: 236 VEFPELN--TEETKTFVKTTLMKAADLEKDWFRYIIGD-KIPGINPEDMETYISFIANKR 292 Query: 317 MQAVGLDLPF-QTRSNPIPWINTW 339 +G++ P+ + + NP+ WI + Sbjct: 293 AVQLGMEKPYPEIKHNPMKWIRAY 316 >4M1I-A nrPDB Length = 366 Score = 82.8 bits (203), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 74/293 (25%), Positives = 141/293 (48%), Gaps = 28/293 (9%) Query: 49 WRPEEVDVSRDRIDYQA--LPEHEKHIFISNLKYQTLLDSIQGRSPNVALLPLISIPELE 106 W P E+ + +D +++ L E E+ + + NL + + +S+ G + +A+ ++ PE Sbjct: 71 WLPTEIPMGKDIELWKSDRLSEDERRVILLNLGFFSTAESLVGNNIVLAIFKHVTNPEAR 130 Query: 107 TWVETWAFSETIHSRSYTHIIRNIVNDPSVVFDDIVTNEQIQKRAEGISSYYDELIEMTS 166 ++ AF E +H+ ++ +I ++ D +F+ NE+ +A+ D +E+T Sbjct: 131 QYLLRQAFEEAVHTHTFLYICESLGLDEKEIFN--AYNERAAIKAKD-----DFQMEITG 183 Query: 167 YWHLLGEGTHTVNGKTVTVSLRELKKKL--YLCLMSVNALEAIRFYVSFACSFAFAEREL 224 T +V G L+E K L Y +M E I FY F +F + Sbjct: 184 KVLDPNFRTDSVEG------LQEFVKNLVGYYIIM-----EGIFFYSGFVMILSFHRQNK 232 Query: 225 MEGNAKIIRLIARDEALHLTGTQHMLNLLRSGADDPEMAEIAEECKQECYDLFVQAAQQE 284 M G + + I RDE +HL ++N ++ ++PE+ E +QE +L +A E Sbjct: 233 MIGIGEQYQYILRDETIHLNFGIDLINGIKE--ENPEIW--TPELQQEIVELIKRAVDLE 288 Query: 285 KDWADYLFRDGSMIGLNKDILCQYVEYITNIRMQAVGLDLPFQTRSNPIPWIN 337 ++A G ++GL + YV++I + R++ +GL + T+ NP PW++ Sbjct: 289 IEYAQDCLPRG-ILGLRASMFIDYVQHIADRRLERIGLKPIYHTK-NPFPWMS 339 >3DHZ-A nrPDB Length = 329 Score = 81.6 bits (200), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 88/351 (25%), Positives = 150/351 (42%), Gaps = 61/351 (17%) Query: 30 DQQKYDIFEKLIEKQLSFFWRPEEVDVSRDRIDYQALPEHEKHIFISNLKYQTLLDSIQG 89 D++ +++++L FW PE++ VS D + + E+ + TLLD+IQG Sbjct: 26 DEKDLEVWDRLTGN----FWLPEKIPVSNDIQSWNKMTPQEQLATMRVFTGLTLLDTIQG 81 Query: 90 RSPNVALLPLISIPELETWVETWAFSETIHSRSYTHIIRNIVNDPSV--VFDDIVTNEQI 147 ++LLP E AF E++H++SY++I + + P + F NE + Sbjct: 82 TVGAISLLPDAETMHEEAVYTNIAFMESVHAKSYSNIFMTLASTPQINEAFRWSEENENL 141 Query: 148 QKRAEGISSYYDELIEMTSYWHLLGEGTHTVNGKTVTVSLRELKKKLYLCLMSVNALEAI 207 Q++A+ I SYY NG LKKK+ L LE+ Sbjct: 142 QRKAKIIMSYY--------------------NGDD------PLKKKVASTL-----LESF 170 Query: 208 RFYVSFACSFAFAERELMEGNAKIIRLIARDEALHLTGTQHMLNLLRSGADDPEMAEIAE 267 FY F + R + A IIRLI RDE++H ++ + G AE E Sbjct: 171 LFYSGFYLPMYLSSRAKLTNTADIIRLIIRDESVH---GYYIGYKYQQGVKKLSEAE-QE 226 Query: 268 ECKQECYDLFVQAAQQEKDWADYLFRDGSMIGLNKDILCQYVEYITNIRMQAVGLDLPFQ 327 E K +DL + E ++ + ++ D +G +D+ +++ Y N + +G + F Sbjct: 227 EYKAYTFDLMYDLYENEIEYTEDIYDD---LGWTEDV-KRFLRYNANKALNNLGYEGLFP 282 Query: 328 TRSNPI-PWINTWLVSDNVQVAPQEVE--------VSSYLVGQIDSEVDTD 369 T + P I + ++P E SSY++G+ + D D Sbjct: 283 TDETKVSPAILS-------SLSPNADENHDFFSGSGSSYVIGKAEDTTDDD 326 >3MJO-A nrPDB Length = 296 Score = 81.6 bits (200), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 79/303 (26%), Positives = 133/303 (43%), Gaps = 49/303 (16%) Query: 30 DQQKYDIFEKLIEKQLSFFWRPEEVDVSRDRIDYQALPEHEKHIFISNLKYQTLLDSIQG 89 D++ +++++L FW PE++ VS D + + E+ + TLLD+IQG Sbjct: 25 DEKDLEVWDRLTGN----FWLPEKIPVSNDIQSWNKMTPQEQLATMRVFTGLTLLDTIQG 80 Query: 90 RSPNVALLPLISIPELETWVETWAFSETIHSRSYTHIIRNIVNDPSV--VFDDIVTNEQI 147 ++LLP E AF E++H++SY++I + + P + F NE + Sbjct: 81 TVGAISLLPDAETMHEEAVYTNIAFMESVHAKSYSNIFMTLASTPQINEAFRWSEENENL 140 Query: 148 QKRAEGISSYYDELIEMTSYWHLLGEGTHTVNGKTVTVSLRELKKKLYLCLMSVNALEAI 207 Q++A+ I SYY NG LKKK+ L LE+ Sbjct: 141 QRKAKIIMSYY--------------------NGDD------PLKKKVASTL-----LESF 169 Query: 208 RFYVSFACSFAFAERELMEGNAKIIRLIARDEALH--LTGTQHMLNLLRSGADDPEMAEI 265 FY F + R + A IIRLI RDE++H G ++ + G AE Sbjct: 170 LFYSGFYLPMYLSSRAKLTNTADIIRLIIRDESVHGYYIGYKY-----QQGVKKLSEAE- 223 Query: 266 AEECKQECYDLFVQAAQQEKDWADYLFRDGSMIGLNKDILCQYVEYITNIRMQAVGLDLP 325 EE K +DL + E ++ + ++ D +G +D+ +++ Y N + +G + Sbjct: 224 QEEYKAYTFDLMYDLYENEIEYTEDIYDD---LGWTEDV-KRFLRYNANKALNNLGYEGL 279 Query: 326 FQT 328 F T Sbjct: 280 FPT 282 >1UZR-A nrPDB Length = 296 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 80/310 (25%), Positives = 136/310 (43%), Gaps = 52/310 (16%) Query: 30 DQQKYDIFEKLIEKQLSFFWRPEEVDVSRDRIDYQALPEHEKHIFISNLKYQTLLDSIQG 89 D++ +++++L FW PE+V VS D + L EK + + T+LD+IQG Sbjct: 21 DEKDAEVWDRLTGN----FWLPEKVPVSNDIPSWGTLTAGEKQLTMRVFTGLTMLDTIQG 76 Query: 90 RSPNVALLPLISIPELETWVETWAFSETIHSRSYTHIIRNIVNDPSVVFDDIVT----NE 145 V+L+P P E + AF E++H++SY+ I + + + DD N Sbjct: 77 TVGAVSLIPDALTPHEEAVLTNIAFMESVHAKSYSQIFSTLCSTAEI--DDAFRWSEENR 134 Query: 146 QIQKRAEGISSYYDELIEMTSYWHLLGEGTHTVNGKTVTVSLRELKKKLYLCLMSVNALE 205 +Q++AE I + SY G+ LK+K+ L LE Sbjct: 135 NLQRKAE---------IVLQSY---RGD--------------EPLKRKVASTL-----LE 163 Query: 206 AIRFYVSFACSFAFAERELMEGNAKIIRLIARDEALHLTGTQHMLNLLRSGADDPEMAEI 265 + FY F ++ R + A +IRLI RDEA+H + + DD AE+ Sbjct: 164 SFLFYSGFYLPMYWSSRAKLTNTADMIRLIIRDEAVHGYYIGYKFQRGLALVDDVTRAEL 223 Query: 266 AEECKQECYDLFVQAAQQEKDWADYLFRDGSMIGLNKDILCQYVEYITNIRMQAVGLDLP 325 K Y+L + E ++ L+ + +GL +D+ +++ Y N + +G + Sbjct: 224 ----KDYTYELLFELYDNEVEYTQDLYDE---VGLTEDV-KKFLRYNANKALMNLGYEAL 275 Query: 326 F---QTRSNP 332 F +T NP Sbjct: 276 FPRDETDVNP 285 >4BMQ-A nrPDB Length = 322 Score = 79.3 bits (194), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 77/306 (25%), Positives = 144/306 (47%), Gaps = 35/306 (11%) Query: 32 QKYDIFEKLIEKQ-LSFFWRPEEVDVSRDRIDYQALPEHEKHIFISNLKYQTLLDSIQGR 90 +K D F + KQ ++ FW EE+ VS D+ + L + E+ + L TLLD+ QG Sbjct: 8 KKEDDFSLMFWKQNIAQFWTEEEIAVSSDKNTWVQLSKEEQIAYKRVLGGLTLLDTKQGG 67 Query: 91 SPNVALLPLISIPELETWVETWAFSETIHSRSYTHIIRNIVNDPSV--VFDDIVTNEQIQ 148 +L + + ++ + E +H++SY+HI + + + +FD + + ++ Sbjct: 68 EGMPLVLVHLENLQAKSVLAFMGAMEEVHAKSYSHIFTTLATEEEIDDIFDWVDNHPLLE 127 Query: 149 KRAEGISSYYDELIEMTSYWHLLGEGTHTVNGKTVTVSLRELKKKLYLCLMSVNALEAIR 208 K+A I+SYY L++ VT KK+LY+ +++ LE+ Sbjct: 128 KKAGIITSYYRRLLK-----------------PEVT------KKELYMAMVASVFLESYL 164 Query: 209 FYVSFACSFAFAERELMEGNAKIIRLIARDEALHLTGTQHMLNLLRSGADDPEMAEIAEE 268 FY F A + + + +II LI RDE++H + +L AE +E Sbjct: 165 FYSGFFYPLYLAGQGKLTASGEIINLIIRDESIHGV----FVGILAQQIFAELSAEEQQE 220 Query: 269 CKQECYDLFVQAAQQEKDWADYLFRDGSMIGLNKDILCQYVEYITNIRMQAVGLDLPFQT 328 ++E +L ++ + E + + ++ + IGL +D+ ++V Y N + +GL+ F+ Sbjct: 221 VQKETQELLMELYEIEMAYTEEIY---TSIGLVEDV-NRFVRYNANKGLMNLGLEPKFEE 276 Query: 329 RS-NPI 333 NPI Sbjct: 277 EEINPI 282 >2BQ1-I nrPDB Length = 319 Score = 73.6 bits (179), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 74/285 (25%), Positives = 117/285 (41%), Gaps = 45/285 (15%) Query: 46 SFFWRPEEVDVSRDRIDYQALPEHEKHIFISNLKYQTLLDSIQGRSPNVALLPLISIPEL 105 S FW PE+V +S D +Q L E+ + I TLLD+IQ + +L+ P Sbjct: 28 SNFWLPEKVPLSNDIPAWQTLSAAEQQLTIRVFTGLTLLDTIQNIAGAPSLMADAITPHE 87 Query: 106 ETWVETWAFSETIHSRSYTHIIRNIVNDPSV--VFDDIVTNEQIQKRAEGISSYYDELIE 163 E + +F E +H+RSY+ I + V + N +Q++A+ I ++Y Sbjct: 88 EAVLSNISFMEAVHARSYSSIFSTLCQTKEVDAAYAWSEENPPLQRKAQIILAHY----- 142 Query: 164 MTSYWHLLGEGTHTVNGKTVTVSLRELKKKLYLCLMSVNALEAIRFYVSFACSFAFAERE 223 VS LKKK+ LE+ FY F F+ R Sbjct: 143 ---------------------VSDEPLKKKIASVF-----LESFLFYSGFWLPMYFSSRG 176 Query: 224 LMEGNAKIIRLIARDEALH--LTGTQHMLNLLRSGADDPEMAEIAEECKQECYDLFVQAA 281 + A +IRLI RDEA+H G ++ + L + A + EE K DL ++ Sbjct: 177 KLTNTADLIRLIIRDEAVHGYYIGYKYQIALQKLSAIE------REELKLFALDLLMELY 230 Query: 282 QQEKDWADYLFRDGSMIGLNKDILCQYVEYITNIRMQAVGLDLPF 326 E + + L+ + + K LC Y N + +G + F Sbjct: 231 DNEIRYTEALYAETGWVNDVKAFLC----YNANKALMNLGYEALF 271 >3N37-A nrPDB Length = 319 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 66/265 (24%), Positives = 105/265 (39%), Gaps = 41/265 (15%) Query: 46 SFFWRPEEVDVSRDRIDYQALPEHEKHIFISNLKYQTLLDSIQGRSPNVALLPLISIPEL 105 S FW PE+V +S D +Q L E+ + + TLLD++Q +L+P P Sbjct: 28 SNFWLPEKVPLSNDIPAWQTLTVVEQQLTMRVFTGLTLLDTLQNVIGAPSLMPDALTPHE 87 Query: 106 ETWVETWAFSETIHSRSYTHIIRNI--VNDPSVVFDDIVTNEQIQKRAEGISSYYDELIE 163 E + +F E +H+RSY+ I + D + N +Q++A+ I +Y Sbjct: 88 EAVLSNISFMEAVHARSYSSIFSTLCQTKDVDAAYAWSEENAPLQRKAQIIQQHY----- 142 Query: 164 MTSYWHLLGEGTHTVNGKTVTVSLRELKKKLYLCLMSVNALEAIRFYVSFACSFAFAERE 223 G + K +V LE+ FY F F+ R Sbjct: 143 ---------RGDDPLKKKIASV-----------------FLESFLFYSGFWLPMYFSSRG 176 Query: 224 LMEGNAKIIRLIARDEALH--LTGTQHMLNLLRSGADDPEMAEIAEECKQECYDLFVQAA 281 + A +IRLI RDEA+H G ++ N+ + EE K +DL ++ Sbjct: 177 KLTNTADLIRLIIRDEAVHGYYIGYKYQKNMEKISLGQ------REELKSFAFDLLLELY 230 Query: 282 QQEKDWADYLFRDGSMIGLNKDILC 306 E + D L+ + K LC Sbjct: 231 DNELQYTDELYAETPWADDVKAFLC 255 >4DR0-A nrPDB Length = 350 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 67/313 (21%), Positives = 139/313 (44%), Gaps = 37/313 (11%) Query: 25 NVARYDQQKYDIFEKLIEKQLSFFWRPEEVDVSRDRIDYQALPEHEKHIFISNLKYQTLL 84 + A + + + D + + + FW PEE+ ++ D + ++ L ++E+ ++ L TLL Sbjct: 27 DAANWSKHEDDFTQMFYNQNVKQFWLPEEIALNGDLLTWKYLGKNEQDTYMKVLAGLTLL 86 Query: 85 DSIQGRSPNVALLPLISIPELETWVETWAFSE-TIHSRSYTHIIRNIVNDPSV--VFDDI 141 D+ QG + + + + + + A E +H++SY++I + ++ VF+ + Sbjct: 87 DTEQGNTGMPIVAEHVDGHQRKAVLNFMAMMENAVHAKSYSNIFMTLAPTETINEVFEWV 146 Query: 142 VTNEQIQKRAEGISSYYDELIEMTSYWHLLGEGTHTVNGKTVTVSLRELKKKLYLCLMSV 201 N+ +QK+A+ I Y + ++ + L+ +++ Sbjct: 147 KQNKYLQKKAQMIVGLYKAI-------------------------QKDDEISLFKAMVAS 181 Query: 202 NALEAIRFYVSFACSFAFAERELMEGNAKIIRLIARDEALHLTGTQHMLNLLRSGADDPE 261 LE+ FY F F + + + +II LI RDEA+H + LL + + Sbjct: 182 VYLESFLFYSGFYYPLYFYGQGKLMQSGEIINLILRDEAIHGV----YVGLLAQEIYNKQ 237 Query: 262 MAEIAEECKQECYDLFVQAAQQEKDWADYLFRDGSMIGLNKDILCQYVEYITNIRMQAVG 321 E E ++ DL Q + E ++ + L+ +GL+ D+ +++ Y N + +G Sbjct: 238 TEEKKAELREFAIDLLNQLYENELEYTEDLY---DQVGLSHDV-KKFIRYNANKALMNLG 293 Query: 322 LDLPFQTRS-NPI 333 D F+ NPI Sbjct: 294 FDPYFEEEDINPI 306 >1H0O-A nrPDB Length = 390 Score = 68.6 bits (166), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 75/326 (23%), Positives = 132/326 (40%), Gaps = 50/326 (15%) Query: 16 EPMFFGQPVNVARYDQQKYDIFEKLIEKQLSFFWRPEEVDVSRDRIDYQALPEHEKHIFI 75 EP+ P + + +DI++ + +K + FW EEVD+S+D ++AL E+H Sbjct: 71 EPLLRENPRRFVVFPIEYHDIWQ-MYKKAEASFWTAEEVDLSKDIQHWEALKPDERHFIS 129 Query: 76 SNLKYQTLLDSIQGRSPNVALLPLISIPELETWVETWAFSETIHSRSYTHIIRNIVNDPS 135 L + D I + + + E + E IHS Y+ +I + DP Sbjct: 130 HVLAFFAASDGIVNENLVERFSQEVQVTEARCFYGFQIAMENIHSEMYSLLIDTYIKDPK 189 Query: 136 ---VVFDDIVTNEQIQKRAEGISSYYDELIEMTSYWHL--LGEGTHTVNGKTVTVSLREL 190 +F+ I T ++K+A+ W L +G+ T + V + Sbjct: 190 EREYLFNAIETMPCVKKKAD---------------WALRWIGDKEATYGERVVAFA---- 230 Query: 191 KKKLYLCLMSVNALEAIRFYVSFACSFAFAERELMEGNAKIIRLIARDEALHLTGTQHML 250 A+E I F SFA F +R LM G LI+RDE LH M Sbjct: 231 ------------AVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMF 278 Query: 251 NLLRSGADDPEMAEIAEECKQECYDLFVQAAQQEKDWADYLFRDGSMIGLNKDILCQYVE 310 L + + +Q ++ A + E+++ +IG+N ++ QY+E Sbjct: 279 KHL-----------VHKPAEQRVREIITNAVRIEQEFLTEAL-PVKLIGMNCTLMKQYIE 326 Query: 311 YITNIRMQAVGLDLPFQTRSNPIPWI 336 ++ + M +G + F+ NP ++ Sbjct: 327 FVADRLMLELGFNKIFRV-ENPFDFM 351 >4DJN-A nrPDB Length = 311 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 79/338 (23%), Positives = 134/338 (39%), Gaps = 52/338 (15%) Query: 4 TTFSQTKNDQLKEPMFFGQPVNVARYDQQKYDIFEKLIEKQLSFFWRPEEVDVSRDRIDY 63 T S+ K+++ EP+ + Q DI++ + Q SF W EEVD+S+D + Sbjct: 11 TNESEIKSNE--EPLLRKSSRRFVIFPIQYPDIWKMYKQAQASF-WTAEEVDLSKDLPHW 67 Query: 64 QALPEHEKHIFISNLKYQTLLDSIQGRSPNVALLPLISIPELETWVETWAFSETIHSRSY 123 L EK+ L + D I + + +PE + E +HS Y Sbjct: 68 NKLKADEKYFISHILAFFAASDGIVNENLVERFSQEVQVPEARCFYGFQILIENVHSEMY 127 Query: 124 THIIRNIVNDPS---VVFDDIVTNEQIQKRAEGISSYYDELIEMTSYWHL--LGEGTHTV 178 + +I + DP +F+ I T ++K+A+ W L + + T Sbjct: 128 SLLIDTYIRDPKKREFLFNAIETMPYVKKKAD---------------WALRWIADRKSTF 172 Query: 179 NGKTVTVSLRELKKKLYLCLMSVNALEAIRFYVSFACSFAFAERELMEGNAKIIRLIARD 238 + V + A+E + F SFA F +R LM G LI+RD Sbjct: 173 GERVVAFA----------------AVEGVFFSGSFAAIFWLKKRGLMPGLTFSNELISRD 216 Query: 239 EALHLTGTQHMLNLLRSGADDPEMAEIAEECKQECYDLFVQAAQQEKDWADYLFRDGSMI 298 E LH M L + + + EI V A + E+++ G +I Sbjct: 217 EGLHCDFACLMFQYLVNKPSEERVREI-----------IVDAVKIEQEFLTEALPVG-LI 264 Query: 299 GLNKDILCQYVEYITNIRMQAVGLDLPFQTRSNPIPWI 336 G+N ++ QY+E++ + + +G FQ NP ++ Sbjct: 265 GMNCILMKQYIEFVADRLLVELGFSKVFQA-ENPFDFM 301 >6GP2-A nrPDB Length = 345 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 74/294 (25%), Positives = 121/294 (41%), Gaps = 52/294 (17%) Query: 48 FWRPEEVDVSRDRIDYQALPEHEKHIFISNLKYQTLLDSIQGRSPNVALLPLISIPELET 107 FW PE++ VS D ++ L + + TLLD+IQ +VA +P S+ + E Sbjct: 56 FWLPEKIPVSNDLTSWRTLTPEWQELITRTFTGLTLLDTIQATVGDVAQVP-NSLTDHEQ 114 Query: 108 WVET-WAFSETIHSRSYTHIIRNIVNDPSV--VFDDIVTNEQIQKRAEGISSYYDELIEM 164 + T +AF +H+RS+ I + + + + ++ E +Q+RA+ + YY Sbjct: 115 VIYTNFAFMVAVHARSFGSIFSTLCSSEQIEEAHEWVINTETLQERAKALIPYY------ 168 Query: 165 TSYWHLLGEGTHTVNGKTVTVSLRELKKKLYLCLMSVNALEAIRFYVSFACSFAFAEREL 224 V+ LK K+ LM Y F F + R Sbjct: 169 --------------------VNDDPLKSKVAAALMP-----GFLLYGGFYLPFYLSARGK 203 Query: 225 MEGNAKIIRLIARDEALH--LTGTQHMLNLLR-SGADDPEMAEIAEECKQECYDLFVQAA 281 + + IIRLI RD+ +H +G ++ + + S EM E + E DL Sbjct: 204 LPNTSDIIRLILRDKVIHNYYSGYKYQKKVAKLSPEKQAEMKEFVFKLLYELIDL----- 258 Query: 282 QQEKDWADYLFRDGSMIGLNKDILCQYVEYITNIRMQAVGLDLPF---QTRSNP 332 EK + L+ D GL D + ++ Y +Q +G D PF +TR P Sbjct: 259 --EKAYLKELYED---FGLADDAI-RFSVYNAGKFLQNLGYDSPFTEEETRIEP 306 >3HF1-A nrPDB Length = 351 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 79/338 (23%), Positives = 132/338 (39%), Gaps = 53/338 (15%) Query: 7 SQTKNDQLK---EPMFFGQPVNVARYDQQKYDIFEKLIEKQLSFFWRPEEVDVSRDRIDY 63 S T ++K EP+ + Q DI++ + Q SF W EEVD+S+D + Sbjct: 20 SDTNESEIKSNEEPLLRKSSRRFVIFPIQYPDIWKMYKQAQASF-WTAEEVDLSKDLPHW 78 Query: 64 QALPEHEKHIFISNLKYQTLLDSIQGRSPNVALLPLISIPELETWVETWAFSETIHSRSY 123 L EK+ L + D I + + +PE + E +HS Y Sbjct: 79 NKLKADEKYFISHILAFFAASDGIVNENLVERFSQEVQVPEARCFYGFQILIENVHSEMY 138 Query: 124 THIIRNIVNDPS---VVFDDIVTNEQIQKRAEGISSYYDELIEMTSYWHL--LGEGTHTV 178 + +I + DP +F+ I T ++K+A+ W L + + T Sbjct: 139 SLLIDTYIRDPKKREFLFNAIETMPYVKKKAD---------------WALRWIADRKSTF 183 Query: 179 NGKTVTVSLRELKKKLYLCLMSVNALEAIRFYVSFACSFAFAERELMEGNAKIIRLIARD 238 + V + A+E + F SFA F +R LM G LI+RD Sbjct: 184 GERVVAFA----------------AVEGVFFSGSFAAIFWLKKRGLMPGLTFSNELISRD 227 Query: 239 EALHLTGTQHMLNLLRSGADDPEMAEIAEECKQECYDLFVQAAQQEKDWADYLFRDGSMI 298 E LH M L + + + EI V A + E+++ G +I Sbjct: 228 EGLHCDFACLMFQYLVNKPSEERVREI-----------IVDAVKIEQEFLTEALPVG-LI 275 Query: 299 GLNKDILCQYVEYITNIRMQAVGLDLPFQTRSNPIPWI 336 G+N ++ QY+E++ + + +G FQ NP ++ Sbjct: 276 GMNCILMKQYIEFVADRLLVELGFSKVFQA-ENPFDFM 312 >4N83-A nrPDB Length = 319 Score = 65.9 bits (159), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 81/338 (23%), Positives = 137/338 (40%), Gaps = 50/338 (14%) Query: 37 FEKLIEKQLSFFWRPEEVDVSRDRIDYQALPEHEKHIFISNLKYQTLLDSIQGRSPNVAL 96 +EKL E+ FW + +S D D++ L EK + TLLD++Q S AL Sbjct: 22 WEKLTEQ----FWLDTRIPLSNDLDDWRKLSHKEKDLVGKVFGGLTLLDTLQSESGVDAL 77 Query: 97 LPLISIPELETWVETWAFSETIHSRSYTHIIRNIVNDPSV--VFDDIVTNEQIQKRAEGI 154 + E F E++H++SY+ I + + +F TN +QK+AE I Sbjct: 78 RKDVRTAHEEAVFNNIQFMESVHAKSYSSIFSTLNTKSEIDEIFAWTNTNPYLQKKAEII 137 Query: 155 SSYYDELIEMTSYWHLLGEGTHTVNGKTVTVSLRELKKKLYLCLMSVNALEAIRFYVSFA 214 + Y +NG L+KK+ LE FY F Sbjct: 138 NEIY-------------------LNGTA-------LEKKIASVF-----LETFLFYSGFF 166 Query: 215 CSFAFAERELMEGNAKIIRLIARDEALHLTGTQHMLNLLRSGADDPEMAEIAEECKQECY 274 + + A+II+LI RDE++H T + L + + E E+ K+ Y Sbjct: 167 TPLYYLGNNKLANVAEIIKLIIRDESVHGTYIGYKFQLAFNELPEDEQ----EKLKEWMY 222 Query: 275 DLFVQAAQQEKDWADYLFRDGSMIGLNKDILCQYVEYITNIRMQAVGLDLPFQTRS---N 331 DL + E+ + + L+ +G +++ ++ Y N + +G D F + N Sbjct: 223 DLLYTLYENEEGYTESLY---DTVGWTEEVKT-FLRYNANKALMNLGQDPLFPDSADDVN 278 Query: 332 PIPWINTWLVSDNVQVAPQEVEVSSYLVGQIDSEVDTD 369 PI + N Q + YL+G++++ D D Sbjct: 279 PIVMNGISTGTSNHDFFSQ--VGNGYLLGEVEAMQDDD 314 >3OLJ-A nrPDB Length = 286 Score = 64.7 bits (156), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 75/323 (23%), Positives = 128/323 (39%), Gaps = 50/323 (15%) Query: 16 EPMFFGQPVNVARYDQQKYDIFEKLIEKQLSFFWRPEEVDVSRDRIDYQALPEHEKHIFI 75 EP+ P + + +DI++ + +K + FW EEVD+S+D +++L E++ Sbjct: 6 EPLLRENPRRFVIFPIEYHDIWQ-MYKKAEASFWTAEEVDLSKDIQHWESLKPEERYFIS 64 Query: 76 SNLKYQTLLDSIQGRSPNVALLPLISIPELETWVETWAFSETIHSRSYTHIIRNIVNDPS 135 L + D I + + I E + E IHS Y+ +I + DP Sbjct: 65 HVLAFFAASDGIVNENLVERFSQEVQITEARCFYGFQIAMENIHSEMYSLLIDTYIKDPK 124 Query: 136 ---VVFDDIVTNEQIQKRAEGISSYYDELIEMTSYWHL--LGEGTHTVNGKTVTVSLREL 190 +F+ I T ++K+A+ W L +G+ T + V + Sbjct: 125 EREFLFNAIETMPCVKKKAD---------------WALRWIGDKEATYGERVVAFA---- 165 Query: 191 KKKLYLCLMSVNALEAIRFYVSFACSFAFAERELMEGNAKIIRLIARDEALHLTGTQHML 250 A+E I F SFA F +R LM G LI+RDE LH M Sbjct: 166 ------------AVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMF 213 Query: 251 NLLRSGADDPEMAEIAEECKQECYDLFVQAAQQEKDWADYLFRDGSMIGLNKDILCQYVE 310 L + + EI + A + E+++ +IG+N ++ QY+E Sbjct: 214 KHLVHKPSEERVREI-----------IINAVRIEQEFLTEAL-PVKLIGMNCTLMKQYIE 261 Query: 311 YITNIRMQAVGLDLPFQTRSNPI 333 ++ + M +G F+ NP Sbjct: 262 FVADRLMLELGFSKVFRV-ENPF 283 >1SMQ-A nrPDB Length = 399 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 66/278 (23%), Positives = 112/278 (40%), Gaps = 45/278 (16%) Query: 48 FWRPEEVDVSRDRIDYQALPEHEKHIFISN-LKYQTLLDSIQGRSPNVALLPLISIPELE 106 FW EE+D+S+D D+ + FIS L + D I + + IPE + Sbjct: 107 FWTAEEIDLSKDIHDWNNRMNENERFFISRVLAFFAASDGIVNENLVENFSTEVQIPEAK 166 Query: 107 TWVETWAFSETIHSRSYTHIIRNIVNDPS---VVFDDIVTNEQIQKRAEGISSYYDELIE 163 ++ E IHS +Y+ +I + DP +F+ I T +I ++AE + + Sbjct: 167 SFYGFQIMIENIHSETYSLLIDTYIKDPKESEFLFNAIHTIPEIGEKAEWALRWIQDADA 226 Query: 164 MTSYWHLLGEGTHTVNGKTVTVSLRELKKKLYLCLMSVNALEAIRFYVSFACSFAFAERE 223 L GE L++ ++E + F SFA F +R Sbjct: 227 ------LFGER-----------------------LVAFASIEGVFFSGSFASIFWLKKRG 257 Query: 224 LMEGNAKIIRLIARDEALHLTGTQHMLNLLRSGADDPEMAEIAEECKQECYDLFVQAAQQ 283 +M G LI RDE LH + L++ D + +I E + F+ A Sbjct: 258 MMPGLTFSNELICRDEGLHTDFACLLFAHLKNKPDPAIVEKIVTEAVEIEQRYFLDALPV 317 Query: 284 EKDWADYLFRDGSMIGLNKDILCQYVEYITNIRMQAVG 321 +++G+N D++ QYVE++ + + A G Sbjct: 318 ------------ALLGMNADLMNQYVEFVADRLLVAFG 343 >2UW2-A nrPDB Length = 332 Score = 61.6 bits (148), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 72/326 (22%), Positives = 131/326 (40%), Gaps = 50/326 (15%) Query: 16 EPMFFGQPVNVARYDQQKYDIFEKLIEKQLSFFWRPEEVDVSRDRIDYQALPEHEKHIFI 75 EP+ P + + +DI++ + +K + FW EEVD+S+D +++L E++ Sbjct: 13 EPLLRENPRRFVIFPIEYHDIWQ-MYKKAEASFWTAEEVDLSKDIQHWESLKPEERYFIS 71 Query: 76 SNLKYQTLLDSIQGRSPNVALLPLISIPELETWVETWAFSETIHSRSYTHIIRNIVNDPS 135 L + D I + + I E + E IHS Y+ +I + DP Sbjct: 72 HVLAFFAASDGIVNENLVERFSQEVQITEARCFYGFQIAMENIHSEMYSLLIDTYIKDPK 131 Query: 136 ---VVFDDIVTNEQIQKRAEGISSYYDELIEMTSYWHL--LGEGTHTVNGKTVTVSLREL 190 +F+ I T ++K+A+ W L +G+ T + V + Sbjct: 132 EREFLFNAIETMPCVKKKAD---------------WALRWIGDKEATYGERVVAFA---- 172 Query: 191 KKKLYLCLMSVNALEAIRFYVSFACSFAFAERELMEGNAKIIRLIARDEALHLTGTQHML 250 A+E I F SFA F +R M G LI+RDE LH M Sbjct: 173 ------------AVEGIFFSGSFASIFWLKKRGPMPGLTFSNELISRDEGLHCDFACLMF 220 Query: 251 NLLRSGADDPEMAEIAEECKQECYDLFVQAAQQEKDWADYLFRDGSMIGLNKDILCQYVE 310 L + + ++ ++ + A + E+++ +IG+N ++ QY+E Sbjct: 221 KHL-----------VHKPSEERVREIIINAVRIEQEFLTEAL-PVKLIGMNCTLMKQYIE 268 Query: 311 YITNIRMQAVGLDLPFQTRSNPIPWI 336 ++ + M +G F+ NP ++ Sbjct: 269 FVADRLMLELGFSKVFRV-ENPFDFM 293 >2O1Z-A nrPDB Length = 311 Score = 60.8 bits (146), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 68/292 (23%), Positives = 121/292 (41%), Gaps = 44/292 (15%) Query: 48 FWRPEEVDVSRDRIDYQALPEHEKHIFISNLKYQTLLDSIQGRSPNVALLPLISIPELET 107 FW EE+D+S D D++ L ++EKH L + D I + L + I E + Sbjct: 61 FWTAEEIDLSSDLKDFEKLNDNEKHFIKHVLAFFAASDGIVLENLASKFLRQVKITEAKK 120 Query: 108 WVETWAFSETIHSRSYTHIIRNIVNDPSVVFDDIVTNEQIQKRAEGISSYYDELIEMTSY 167 + E IHS +Y+ +I N + D E + Sbjct: 121 FYAFQIAVENIHSETYSLLIDNYIKDEK---------------------------ERMNL 153 Query: 168 WHLLGEGTHTVNGKTVTVSLRELKKKLYLCLMSVNA-LEAIRFYVSFACSFAFAERELME 226 +H + E V K + + + + NA +E I F SF F F ++ + Sbjct: 154 FHAI-ENIPAVKNKALWAAKWINDTNSFAERIVANACVEGILFSGSFCAIFWFKKQNKLH 212 Query: 227 GNAKIIRLIARDEALHLTGTQHMLNLLRSGADDPEMAEIAEECKQECYDLFVQAAQQEKD 286 G LI+RDE LH + +LL + ++ EE Q ++ +A + E+ Sbjct: 213 GLTFSNELISRDEGLHTDFNCLIYSLLEN--------KLPEEVVQ---NIVKEAVEVERS 261 Query: 287 W-ADYLFRDGSMIGLNKDILCQYVEYITNIRMQAVGLDLPFQTRSNPIPWIN 337 + + L D +IG+N ++ QY+E++ + ++ +G F + NP W++ Sbjct: 262 FICESLPCD--LIGMNSRLMSQYIEFVADRLLECLGSPKIFHAK-NPFNWMD 310 >2P1I-A nrPDB Length = 349 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 66/294 (22%), Positives = 121/294 (41%), Gaps = 48/294 (16%) Query: 48 FWRPEEVDVSRDRIDYQALPEHEKHIFISNLKYQTLLDSIQGRSPNVALLPLISIPELET 107 FW EE+D+S D D++ L +EKH L + D I + L + I E + Sbjct: 62 FWTAEEIDLSSDLKDFEKLNVNEKHFIKHVLAFFAASDGIVLENLASKFLREVEIIEAKK 121 Query: 108 WVETWAFSETIHSRSYTHIIRNIVNDPSV---VFDDIVTNEQIQKRAEGISSYYDELIEM 164 + E IHS +Y+ +I N + D +F I I+ +A + + ++ Sbjct: 122 FYSFQIAVENIHSETYSLLIDNYIKDEKERLNLFHAIENIPAIKNKALWAAKWIND---- 177 Query: 165 TSYWHLLGEGTHTVNGKTVTVSLRELKKKLYLCLMSVNALEAIRFYVSFACSFAFAEREL 224 T++ + V + +E I F SF F F ++ Sbjct: 178 ----------TNSFAERIVANA----------------CVEGILFSGSFCAIFWFKKQNK 211 Query: 225 MEGNAKIIRLIARDEALHLTGTQHMLNLLRSGADDPEMAEIAEECKQECYDLFVQAAQQE 284 + G LI+RDE LH + +LL + + + I +E A + E Sbjct: 212 LHGLTFSNELISRDEGLHTDFNCLIYSLLENKLPENVVQNIVKE-----------AVEVE 260 Query: 285 KDW-ADYLFRDGSMIGLNKDILCQYVEYITNIRMQAVGLDLPFQTRSNPIPWIN 337 + + + L D +IG+N ++ QY+E++ + ++ +G F ++ NP W++ Sbjct: 261 RSFICESLPCD--LIGMNSRLMSQYIEFVADRLLECLGCSKVFHSK-NPFNWMD 311 >6EBP-A nrPDB Length = 355 Score = 59.3 bits (142), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 68/292 (23%), Positives = 113/292 (38%), Gaps = 48/292 (16%) Query: 48 FWRPEEVDVSRDRIDYQALPEHEKHIFISNLKYQTLLDSIQGRSPNVALLPLISIPELET 107 FW PE + VS D + L + + + TLLD++Q +VA + + + Sbjct: 66 FWLPENIPVSNDLPSWNELDDDWQQLITRTFTGLTLLDTVQSSIGDVAQIKNSLTEQEQV 125 Query: 108 WVETWAFSETIHSRSYTHIIRNIVNDPSV--VFDDIVTNEQIQKRAEGISSYYDELIEMT 165 +AF +H+RS+ I + + + +V NE +Q R + + +Y Sbjct: 126 IYANFAFMVGVHARSFGTIFSTLCTSEQIEEAHEWVVDNEALQARPKALIPFY------- 178 Query: 166 SYWHLLGEGTHTVNGKTVTVSLRELKKKLYLCLMSVNALEAIRFYVSFACSFAFAERELM 225 + LK K+ LM Y F F + R + Sbjct: 179 -------------------TADDPLKSKIAAALMP-----GFLLYGGFYLPFYLSARGKL 214 Query: 226 EGNAKIIRLIARDEALH--LTGTQHMLNLLRSGADDPEMAEIAEECKQECYDLFVQAAQQ 283 + IIRLI RD+ +H +G ++ L + + E E KQ +DL + Sbjct: 215 PNTSDIIRLILRDKVIHNFYSGYKYQLKVAKLS------PEKQAEMKQFVFDLLDKMIGL 268 Query: 284 EKDWADYLFRDGSMIGLNKDILCQYVEYITNIRMQAVGLDLPF---QTRSNP 332 EK + L+ DG GL D ++ Y +Q +G + PF +TR P Sbjct: 269 EKTYLHQLY-DG--FGL-ADEAIRFSLYNAGKFLQNLGYESPFTKEETRIAP 316 >6QRZ-A nrPDB Length = 328 Score = 37.4 bits (85), Expect = 0.012, Method: Compositional matrix adjust. Identities = 53/222 (23%), Positives = 92/222 (41%), Gaps = 33/222 (14%) Query: 39 KLIEKQLSFFWRPEEVDVSRDRIDYQALPEHEKHIFISNLKYQTLLDSIQGRSPNVALLP 98 KL + FW P ++D S+D+ D++ L + EK+ ++ + L + V + P Sbjct: 47 KLYQIGKRLFWDPAKIDFSKDKEDWKKLSKDEKNYLLNIVS----LFMAGEEAVAVDITP 102 Query: 99 LISI------PELETWVETWAFSETIHSRSYTHIIRNI-VNDPSVVFDDIVTNEQIQKRA 151 LIS E ++E +AF E H+ ++ ++ +ND +F N QK Sbjct: 103 LISTMINEGRVEDVIYLEQFAFEEAKHAEAFRRFCDSLEINDDLTIF-TTEYNPWYQK-- 159 Query: 152 EGISSYYDELIEMTSYWHLLGEGTHTVNGKTVTVSLRELKKKLYLCLMSVNALEAIRFYV 211 +Y+EL + W L V S L + + V + A Y Sbjct: 160 ----IFYEELPSVM--WKL-----------RVDPSPENLAVAVTTYNLYVEGVAAESGYK 202 Query: 212 SFACSFAFAERELMEGNAKIIRLIARDEALHLTGTQHMLNLL 253 +F F +M G +K + LIA DE+ H+ +++ L Sbjct: 203 TF--KHIFNSLNIMPGLSKTVNLIATDESRHIAYGTYLITRL 242 >5OLK-A nrPDB Length = 430 Score = 34.3 bits (77), Expect = 0.10, Method: Compositional matrix adjust. Identities = 45/226 (19%), Positives = 100/226 (44%), Gaps = 33/226 (14%) Query: 103 PELETWVETWAFSETIHSRSYTHIIRNI-VNDPSVVFDDIVTNEQIQKRAEGISSYYDEL 161 PE+ T+A SE H +Y+H++ + +N+ F ++ I KR +Y E Sbjct: 190 PEIAAVGATFAESEVRHHDAYSHLLEILGLNEE---FKELKKKPVIMKRV-----HYLE- 240 Query: 162 IEMTSYWHLLGEGTHTVNGKTVTVSLRELKKKLYLCLMSVNALEAIRFYVSFACSFAF-A 220 TS H + RE + + L + + E + + F AF Sbjct: 241 ---TSLKHAKSDDD------------REYTESILLFALFI---EHVSLFSQFLIIMAFNK 282 Query: 221 ERELMEGNAKIIRLIARDEALHLTGTQHMLNLLRSGADDPEMAEIAEECKQECYDLFVQA 280 + +++G + + +++E +H ++N+++ ++PE + EE ++ + + Sbjct: 283 HKNMLKGISNAVEATSKEEQIHGDFGVDIINIIKK--ENPEWFD--EEHNNLIKEMCLNS 338 Query: 281 AQQEKDWADYLFRDGSMIGLNKDILCQYVEYITNIRMQAVGLDLPF 326 + E D++F G + L K ++ ++++ N ++A+GL+ F Sbjct: 339 FEAESKVVDWIFEKGELDFLPKAVINEFLKNRFNKSLEAIGLEKLF 384 >1SMS-A nrPDB Length = 345 Score = 33.1 bits (74), Expect = 0.20, Method: Compositional matrix adjust. Identities = 50/277 (18%), Positives = 109/277 (39%), Gaps = 45/277 (16%) Query: 48 FWRPEEVDVSRDRIDYQALPEHEKHIFISNLKYQTL-LDSIQGRSPNVALLPLISIPELE 106 FW EE+++++D D+Q L + +K +I NL ++ D++ + + PE + Sbjct: 56 FWTAEEIELAKDTEDFQKLTDDQK-TYIGNLLALSISSDNLVNKYLIENFSAQLQNPEGK 114 Query: 107 TWVETWAFSETIHSRSYTHIIRNIVNDPSVV--FDDIVTNEQIQKRAEGISSYYDELIEM 164 ++ E I+S Y+ ++ DP + F +I +++ +A I + Sbjct: 115 SFYGFQIMMENIYSEVYSMMVDAFFKDPKNIPLFKEIANLPEVKHKAAFIERW------- 167 Query: 165 TSYWHLLGEGTHTVNGKTVTVSLRELKKKLYLCLMSVNALEAIRFYVSFACSFAFAEREL 224 ++ + R L++ A E I ++A F ++++ Sbjct: 168 -------------ISNDDSLYAER---------LVAFAAKEGIFQAGNYASMFWLTDKKI 205 Query: 225 MEGNAKIIRLIARDEALHLTGTQHMLNLLRSGADDPEMAEIAEECKQECYDLFVQAAQQE 284 M G A R I RD + + + LR+ + + +I E + + + + E Sbjct: 206 MPGLAMANRNICRDRGAYTDFSCLLFAHLRTKPNPKIIEKIITEAVEIEKEYYSNSLPVE 265 Query: 285 KDWADYLFRDGSMIGLNKDILCQYVEYITNIRMQAVG 321 K G++ + Y+E++ + +Q G Sbjct: 266 K------------FGMDLKSIHTYIEFVADGLLQGFG 290 >3CNZ-A nrPDB Length = 369 Score = 32.7 bits (73), Expect = 0.25, Method: Compositional matrix adjust. Identities = 25/72 (34%), Positives = 37/72 (51%), Gaps = 9/72 (12%) Query: 65 ALPEHEKHIFISNLKYQTLL-DSIQGRSPNVALLPLISIPELETWVETWAFSETIHSRSY 123 AL +HI N K L+ DS+ G N L ++I E+ ++ ET +S +Y Sbjct: 269 ALSSGNQHIPYRNHKLTMLMSDSLGG---NAKTLMFVNISPAESNLD-----ETHNSLTY 320 Query: 124 THIIRNIVNDPS 135 +R+IVNDPS Sbjct: 321 ASRVRSIVNDPS 332 >4AC8-A nrPDB Length = 323 Score = 32.0 bits (71), Expect = 0.45, Method: Compositional matrix adjust. Identities = 12/33 (36%), Positives = 20/33 (60%) Query: 39 KLIEKQLSFFWRPEEVDVSRDRIDYQALPEHEK 71 KL + FW P ++D +RDR D++ L + E+ Sbjct: 31 KLFAGGNAKFWHPADIDFTRDRADWEKLSDDER 63 >3H4S-A nrPDB Length = 386 Score = 30.4 bits (67), Expect = 1.4, Method: Compositional matrix adjust. Identities = 24/72 (33%), Positives = 35/72 (48%), Gaps = 9/72 (12%) Query: 65 ALPEHEKHIFISNLKYQTLL-DSIQGRSPNVALLPLISIPELETWVETWAFSETIHSRSY 123 AL +HI N K L+ DS+ G N L +++ E+ ++ ET +S Y Sbjct: 277 ALSSGNQHIPYRNHKLTMLMSDSLGG---NAKTLMFVNVSPAESNLD-----ETYNSLLY 328 Query: 124 THIIRNIVNDPS 135 +R IVNDPS Sbjct: 329 ASRVRTIVNDPS 340 >4V0B-A nrPDB Length = 82 Score = 29.3 bits (64), Expect = 2.6, Method: Composition-based stats. Identities = 13/36 (36%), Positives = 21/36 (58%), Gaps = 1/36 (2%) Query: 3 YTTFSQ-TKNDQLKEPMFFGQPVNVARYDQQKYDIF 37 Y+TF Q NDQ++E G+ +NV + D +Y + Sbjct: 12 YSTFLQEVNNDQVREARINGREINVTKKDSNRYTTY 47 >5EIX-A nrPDB Length = 741 Score = 28.1 bits (61), Expect = 5.9, Method: Compositional matrix adjust. Identities = 18/40 (45%), Positives = 24/40 (60%), Gaps = 3/40 (7%) Query: 336 INTWLVSDNVQVAPQEVEVSSYLVGQIDSEVDTDDLSNFQ 375 +NTW VS + +A QEV S +G ID D+DDLS + Sbjct: 58 LNTWEVSSDEVLASQEVHDISVAIG-IDP--DSDDLSQLR 94 >4ZRX-A nrPDB Length = 586 Score = 28.1 bits (61), Expect = 7.2, Method: Compositional matrix adjust. Identities = 11/19 (57%), Positives = 13/19 (68%) Query: 39 KLIEKQLSFFWRPEEVDVS 57 K++EK FW P EVDVS Sbjct: 272 KILEKATELFWYPSEVDVS 290 >3VB0-A nrPDB Length = 294 Score = 28.1 bits (61), Expect = 7.4, Method: Compositional matrix adjust. Identities = 18/60 (30%), Positives = 30/60 (50%), Gaps = 3/60 (5%) Query: 218 AFAERELMEGNAKIIRLIARDEALHL-TGTQHMLNLLRSGADDPEMAEIAEECKQECYDL 276 A ER+ EG ++RL R + L G + L + D ++A IAE+ ++ CY + Sbjct: 31 AVVERD--EGGRALVRLDGRPFRIRLDPGPANRLAAIGWNVDPSDLAAIAEQVEKACYSV 88 >6D6K-A nrPDB Length = 705 Score = 27.7 bits (60), Expect = 7.9, Method: Compositional matrix adjust. Identities = 17/64 (26%), Positives = 29/64 (45%), Gaps = 10/64 (15%) Query: 31 QQKYDIFEKLIEKQLSFFWRPEEVDVSRDRIDYQALPEHEKHIFISNLKYQTLLDSIQGR 90 Q +Y + L + ++ F E+VD D +DY +LKY+T+ D+I Sbjct: 273 QDRYAALDALHAEAVAQFVPEEDVDGIADEVDY----------LFEDLKYRTVRDNILSG 322 Query: 91 SPNV 94 P + Sbjct: 323 KPRI 326 >3WPN-A nrPDB Length = 382 Score = 27.7 bits (60), Expect = 8.2, Method: Compositional matrix adjust. Identities = 22/73 (30%), Positives = 33/73 (45%), Gaps = 9/73 (12%) Query: 65 ALPEHEKHIFISNLKYQTLL-DSIQGRSPNVALLPLISIPELETWVETWAFSETIHSRSY 123 AL E H+ K +L DS+ GR+ +++ IS L ET+ + Y Sbjct: 307 ALVERTPHVPYRESKLTRILQDSLGGRT-RTSIIATISPASLN-------LEETLSTLEY 358 Query: 124 THIIRNIVNDPSV 136 H +NI+N P V Sbjct: 359 AHRAKNILNKPEV 371 >4HGN-A nrPDB Length = 176 Score = 27.7 bits (60), Expect = 8.4, Method: Compositional matrix adjust. Identities = 39/152 (25%), Positives = 65/152 (42%), Gaps = 31/152 (20%) Query: 169 HLLGEGTHTVNGKTVTVSLRELKKKLYLCLMSVNALEAIRFYVSFACSFAFAERELMEGN 228 H GE TVN K +KK L++ +++ EA+R + FA A ++L G+ Sbjct: 33 HPSGEPMRTVNIKDGYAIQLAVKKGLHIAIITGGRTEAVR--IRFA---ALGVKDLYMGS 87 Query: 229 AKIIR---------LIARDEALHLTGTQHMLNLLRSGADDPEMAEIAEECKQECYDLFVQ 279 A I ++ DE L++ G D P++ E+ EC C Sbjct: 88 AVKIHDYRNFRDKYGLSDDEILYM------------GDDVPDI-EVMRECGLPC--CPKD 132 Query: 280 AAQQEKDWADYL-FRDGSMIGLNKDILCQYVE 310 A + K A Y+ + DG G +D++ Q ++ Sbjct: 133 AVPEVKSVAKYISYADGGR-GCGRDVVEQVLK 163 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 1PIY-A nrPDB 468 e-132 1H0O-A nrPDB 310 5e-85 3HF1-A nrPDB 307 4e-84 2UW2-A nrPDB 307 4e-84 4DJN-A nrPDB 307 5e-84 3OLJ-A nrPDB 307 5e-84 3DHZ-A nrPDB 306 2e-83 2BQ1-I nrPDB 289 1e-78 3N37-A nrPDB 288 3e-78 3MJO-A nrPDB 285 2e-77 4DR0-A nrPDB 284 3e-77 1UZR-A nrPDB 284 6e-77 4BMQ-A nrPDB 283 1e-76 4N83-A nrPDB 279 1e-75 2O1Z-A nrPDB 272 1e-73 2P1I-A nrPDB 270 7e-73 6GP2-A nrPDB 269 2e-72 1SMQ-A nrPDB 268 2e-72 6EBP-A nrPDB 265 3e-71 2RCC-A nrPDB 245 2e-65 4M1I-A nrPDB 244 5e-65 Sequences not found previously or not previously below threshold: 1SMS-A nrPDB 172 2e-43 5OLK-A nrPDB 78 6e-15 6QRZ-A nrPDB 77 1e-14 4AC8-A nrPDB 74 1e-13 6CWO-A nrPDB 73 2e-13 6CWP-A nrPDB 73 2e-13 5OMK-A nrPDB 58 5e-09 5XIL-A nrPDB 31 0.61 5W21-A nrPDB 30 1.8 4NMN-A nrPDB 29 4.0 4XFE-A nrPDB 28 5.8 3DFA-A nrPDB 28 8.2 4YZB-A nrPDB 28 8.5 >1PIY-A nrPDB Length = 375 Score = 468 bits (1204), Expect = e-132, Method: Composition-based stats. Identities = 374/375 (99%), Positives = 374/375 (99%) Query: 2 AYTTFSQTKNDQLKEPMFFGQPVNVARYDQQKYDIFEKLIEKQLSFFWRPEEVDVSRDRI 61 AYTTFSQTKNDQLKEPMFFGQPVNVARYDQQKYDIFEKLIEKQLSFFWRPEEVDVSRDRI Sbjct: 1 AYTTFSQTKNDQLKEPMFFGQPVNVARYDQQKYDIFEKLIEKQLSFFWRPEEVDVSRDRI 60 Query: 62 DYQALPEHEKHIFISNLKYQTLLDSIQGRSPNVALLPLISIPELETWVETWAFSETIHSR 121 DYQALPEHEKHIFISNLKYQTLLDSIQGRSPNVALLPLISIPELETWVETWAFSETIHSR Sbjct: 61 DYQALPEHEKHIFISNLKYQTLLDSIQGRSPNVALLPLISIPELETWVETWAFSETIHSR 120 Query: 122 SYTHIIRNIVNDPSVVFDDIVTNEQIQKRAEGISSYYDELIEMTSYWHLLGEGTHTVNGK 181 SYTHIIRNIVNDPSVVFDDIVTNEQIQKRAEGISSYYDELIEMTSYWHLLGEGTHTVNGK Sbjct: 121 SYTHIIRNIVNDPSVVFDDIVTNEQIQKRAEGISSYYDELIEMTSYWHLLGEGTHTVNGK 180 Query: 182 TVTVSLRELKKKLYLCLMSVNALEAIRFYVSFACSFAFAERELMEGNAKIIRLIARDEAL 241 TVTVSLRELKKKLYLCLMSVNALEAIRFYVSFACSFAFAERELMEGNAKIIRLIARDEAL Sbjct: 181 TVTVSLRELKKKLYLCLMSVNALEAIRFYVSFACSFAFAERELMEGNAKIIRLIARDEAL 240 Query: 242 HLTGTQHMLNLLRSGADDPEMAEIAEECKQECYDLFVQAAQQEKDWADYLFRDGSMIGLN 301 HLTGTQHMLNLLRSGADDPEMAEIAEECKQECYDLFVQAAQQEKDWADYLFRDGSMIGLN Sbjct: 241 HLTGTQHMLNLLRSGADDPEMAEIAEECKQECYDLFVQAAQQEKDWADYLFRDGSMIGLN 300 Query: 302 KDILCQYVEYITNIRMQAVGLDLPFQTRSNPIPWINTWLVSDNVQVAPQEVEVSSYLVGQ 361 KDILCQYVEYITNIRMQAVGLDLPF TRSNPIPWINTWLVSDNVQVAPQEVEVSSYLVGQ Sbjct: 301 KDILCQYVEYITNIRMQAVGLDLPFNTRSNPIPWINTWLVSDNVQVAPQEVEVSSYLVGQ 360 Query: 362 IDSEVDTDDLSNFQL 376 IDSEVDTDDLSNFQL Sbjct: 361 IDSEVDTDDLSNFQL 375 >1H0O-A nrPDB Length = 390 Score = 310 bits (794), Expect = 5e-85, Method: Composition-based stats. Identities = 74/340 (21%), Positives = 132/340 (38%), Gaps = 46/340 (13%) Query: 16 EPMFFGQPVNVARYDQQKYDIFEKLIEKQLSFFWRPEEVDVSRDRIDYQALPEHEKHIFI 75 EP+ P + + +DI++ + +K + FW EEVD+S+D ++AL E+H Sbjct: 71 EPLLRENPRRFVVFPIEYHDIWQ-MYKKAEASFWTAEEVDLSKDIQHWEALKPDERHFIS 129 Query: 76 SNLKYQTLLDSIQGRSPNVALLPLISIPELETWVETWAFSETIHSRSYTHIIRNIVNDPS 135 L + D I + + + E + E IHS Y+ +I + DP Sbjct: 130 HVLAFFAASDGIVNENLVERFSQEVQVTEARCFYGFQIAMENIHSEMYSLLIDTYIKDPK 189 Query: 136 ---VVFDDIVTNEQIQKRAEGISSYYDELIEMTSYWHLLGEGTHTVNGKTVTVSLRELKK 192 +F+ I T ++K+A+ + +G+ T + V + Sbjct: 190 EREYLFNAIETMPCVKKKADWALRW-------------IGDKEATYGERVVAFA------ 230 Query: 193 KLYLCLMSVNALEAIRFYVSFACSFAFAERELMEGNAKIIRLIARDEALHLTGTQHMLNL 252 A+E I F SFA F +R LM G LI+RDE LH M Sbjct: 231 ----------AVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFKH 280 Query: 253 LRSGADDPEMAEIAEECKQECYDLFVQAAQQEKDWADYLFRDGSMIGLNKDILCQYVEYI 312 L + Q ++ A + E+++ +IG+N ++ QY+E++ Sbjct: 281 LVHKPAE-----------QRVREIITNAVRIEQEFLTEALP-VKLIGMNCTLMKQYIEFV 328 Query: 313 TNIRMQAVGLDLPFQTRSNPIPWINTWLVSDNVQVAPQEV 352 + M +G + F+ NP ++ + + V Sbjct: 329 ADRLMLELGFNKIFRV-ENPFDFMENISLEGKTNFFEKRV 367 >3HF1-A nrPDB Length = 351 Score = 307 bits (787), Expect = 4e-84, Method: Composition-based stats. Identities = 81/369 (21%), Positives = 143/369 (38%), Gaps = 50/369 (13%) Query: 4 TTFSQTKNDQLKEPMFFGQPVNVARYDQQKYDIFEKLIEKQLSFFWRPEEVDVSRDRIDY 63 T S+ K+++ EP+ + Q DI+ K+ ++ + FW EEVD+S+D + Sbjct: 22 TNESEIKSNE--EPLLRKSSRRFVIFPIQYPDIW-KMYKQAQASFWTAEEVDLSKDLPHW 78 Query: 64 QALPEHEKHIFISNLKYQTLLDSIQGRSPNVALLPLISIPELETWVETWAFSETIHSRSY 123 L EK+ L + D I + + +PE + E +HS Y Sbjct: 79 NKLKADEKYFISHILAFFAASDGIVNENLVERFSQEVQVPEARCFYGFQILIENVHSEMY 138 Query: 124 THIIRNIVNDPS---VVFDDIVTNEQIQKRAEGISSYYDELIEMTSYWHLLGEGTHTVNG 180 + +I + DP +F+ I T ++K+A+ + + + T Sbjct: 139 SLLIDTYIRDPKKREFLFNAIETMPYVKKKADWALRW-------------IADRKSTFGE 185 Query: 181 KTVTVSLRELKKKLYLCLMSVNALEAIRFYVSFACSFAFAERELMEGNAKIIRLIARDEA 240 + V + A+E + F SFA F +R LM G LI+RDE Sbjct: 186 RVVAFA----------------AVEGVFFSGSFAAIFWLKKRGLMPGLTFSNELISRDEG 229 Query: 241 LHLTGTQHMLNLLRSGADDPEMAEIAEECKQECYDLFVQAAQQEKDWADYLFRDGSMIGL 300 LH M L + + + EI V A + E+++ G +IG+ Sbjct: 230 LHCDFACLMFQYLVNKPSEERVREI-----------IVDAVKIEQEFLTEALPVG-LIGM 277 Query: 301 NKDILCQYVEYITNIRMQAVGLDLPFQTRSNPIPWINTWLVSDNVQVAPQEVEVSSYLVG 360 N ++ QY+E++ + + +G FQ NP ++ + E VS Y Sbjct: 278 NCILMKQYIEFVADRLLVELGFSKVFQA-ENPFDFMENISLEGKTNFF--EKRVSEYQRF 334 Query: 361 QIDSEVDTD 369 + +E + Sbjct: 335 AVMAETTDN 343 >2UW2-A nrPDB Length = 332 Score = 307 bits (786), Expect = 4e-84, Method: Composition-based stats. Identities = 73/340 (21%), Positives = 131/340 (38%), Gaps = 46/340 (13%) Query: 16 EPMFFGQPVNVARYDQQKYDIFEKLIEKQLSFFWRPEEVDVSRDRIDYQALPEHEKHIFI 75 EP+ P + + +DI++ + +K + FW EEVD+S+D +++L E++ Sbjct: 13 EPLLRENPRRFVIFPIEYHDIWQ-MYKKAEASFWTAEEVDLSKDIQHWESLKPEERYFIS 71 Query: 76 SNLKYQTLLDSIQGRSPNVALLPLISIPELETWVETWAFSETIHSRSYTHIIRNIVNDPS 135 L + D I + + I E + E IHS Y+ +I + DP Sbjct: 72 HVLAFFAASDGIVNENLVERFSQEVQITEARCFYGFQIAMENIHSEMYSLLIDTYIKDPK 131 Query: 136 ---VVFDDIVTNEQIQKRAEGISSYYDELIEMTSYWHLLGEGTHTVNGKTVTVSLRELKK 192 +F+ I T ++K+A+ + +G+ T + V + Sbjct: 132 EREFLFNAIETMPCVKKKADWALRW-------------IGDKEATYGERVVAFA------ 172 Query: 193 KLYLCLMSVNALEAIRFYVSFACSFAFAERELMEGNAKIIRLIARDEALHLTGTQHMLNL 252 A+E I F SFA F +R M G LI+RDE LH M Sbjct: 173 ----------AVEGIFFSGSFASIFWLKKRGPMPGLTFSNELISRDEGLHCDFACLMFKH 222 Query: 253 LRSGADDPEMAEIAEECKQECYDLFVQAAQQEKDWADYLFRDGSMIGLNKDILCQYVEYI 312 L + + EI + A + E+++ +IG+N ++ QY+E++ Sbjct: 223 LVHKPSEERVREI-----------IINAVRIEQEFLTEALP-VKLIGMNCTLMKQYIEFV 270 Query: 313 TNIRMQAVGLDLPFQTRSNPIPWINTWLVSDNVQVAPQEV 352 + M +G F+ NP ++ + + V Sbjct: 271 ADRLMLELGFSKVFRV-ENPFDFMENISLEGKTNFFEKRV 309 >4DJN-A nrPDB Length = 311 Score = 307 bits (786), Expect = 5e-84, Method: Composition-based stats. Identities = 76/336 (22%), Positives = 134/336 (39%), Gaps = 48/336 (14%) Query: 4 TTFSQTKNDQLKEPMFFGQPVNVARYDQQKYDIFEKLIEKQLSFFWRPEEVDVSRDRIDY 63 T S+ K+++ EP+ + Q DI+ K+ ++ + FW EEVD+S+D + Sbjct: 11 TNESEIKSNE--EPLLRKSSRRFVIFPIQYPDIW-KMYKQAQASFWTAEEVDLSKDLPHW 67 Query: 64 QALPEHEKHIFISNLKYQTLLDSIQGRSPNVALLPLISIPELETWVETWAFSETIHSRSY 123 L EK+ L + D I + + +PE + E +HS Y Sbjct: 68 NKLKADEKYFISHILAFFAASDGIVNENLVERFSQEVQVPEARCFYGFQILIENVHSEMY 127 Query: 124 THIIRNIVNDPS---VVFDDIVTNEQIQKRAEGISSYYDELIEMTSYWHLLGEGTHTVNG 180 + +I + DP +F+ I T ++K+A+ + + + T Sbjct: 128 SLLIDTYIRDPKKREFLFNAIETMPYVKKKADWALRW-------------IADRKSTFGE 174 Query: 181 KTVTVSLRELKKKLYLCLMSVNALEAIRFYVSFACSFAFAERELMEGNAKIIRLIARDEA 240 + V + A+E + F SFA F +R LM G LI+RDE Sbjct: 175 RVVAFA----------------AVEGVFFSGSFAAIFWLKKRGLMPGLTFSNELISRDEG 218 Query: 241 LHLTGTQHMLNLLRSGADDPEMAEIAEECKQECYDLFVQAAQQEKDWADYLFRDGSMIGL 300 LH M L + + + EI V A + E+++ G +IG+ Sbjct: 219 LHCDFACLMFQYLVNKPSEERVREI-----------IVDAVKIEQEFLTEALPVG-LIGM 266 Query: 301 NKDILCQYVEYITNIRMQAVGLDLPFQTRSNPIPWI 336 N ++ QY+E++ + + +G FQ NP ++ Sbjct: 267 NCILMKQYIEFVADRLLVELGFSKVFQA-ENPFDFM 301 >3OLJ-A nrPDB Length = 286 Score = 307 bits (786), Expect = 5e-84, Method: Composition-based stats. Identities = 73/324 (22%), Positives = 129/324 (39%), Gaps = 46/324 (14%) Query: 16 EPMFFGQPVNVARYDQQKYDIFEKLIEKQLSFFWRPEEVDVSRDRIDYQALPEHEKHIFI 75 EP+ P + + +DI++ + +K + FW EEVD+S+D +++L E++ Sbjct: 6 EPLLRENPRRFVIFPIEYHDIWQ-MYKKAEASFWTAEEVDLSKDIQHWESLKPEERYFIS 64 Query: 76 SNLKYQTLLDSIQGRSPNVALLPLISIPELETWVETWAFSETIHSRSYTHIIRNIVNDPS 135 L + D I + + I E + E IHS Y+ +I + DP Sbjct: 65 HVLAFFAASDGIVNENLVERFSQEVQITEARCFYGFQIAMENIHSEMYSLLIDTYIKDPK 124 Query: 136 ---VVFDDIVTNEQIQKRAEGISSYYDELIEMTSYWHLLGEGTHTVNGKTVTVSLRELKK 192 +F+ I T ++K+A+ + +G+ T + V + Sbjct: 125 EREFLFNAIETMPCVKKKADWALRW-------------IGDKEATYGERVVAFA------ 165 Query: 193 KLYLCLMSVNALEAIRFYVSFACSFAFAERELMEGNAKIIRLIARDEALHLTGTQHMLNL 252 A+E I F SFA F +R LM G LI+RDE LH M Sbjct: 166 ----------AVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFKH 215 Query: 253 LRSGADDPEMAEIAEECKQECYDLFVQAAQQEKDWADYLFRDGSMIGLNKDILCQYVEYI 312 L + + EI + A + E+++ +IG+N ++ QY+E++ Sbjct: 216 LVHKPSEERVREI-----------IINAVRIEQEFLTEALP-VKLIGMNCTLMKQYIEFV 263 Query: 313 TNIRMQAVGLDLPFQTRSNPIPWI 336 + M +G F+ NP ++ Sbjct: 264 ADRLMLELGFSKVFRV-ENPFDFM 286 >3DHZ-A nrPDB Length = 329 Score = 306 bits (782), Expect = 2e-83, Method: Composition-based stats. Identities = 86/358 (24%), Positives = 148/358 (41%), Gaps = 55/358 (15%) Query: 22 QPVNVARY----DQQKYDIFEKLIEKQLSFFWRPEEVDVSRDRIDYQALPEHEKHIFISN 77 PV + D++ +++++L FW PE++ VS D + + E+ + Sbjct: 14 DPVKAINWNVIPDEKDLEVWDRLTGN----FWLPEKIPVSNDIQSWNKMTPQEQLATMRV 69 Query: 78 LKYQTLLDSIQGRSPNVALLPLISIPELETWVETWAFSETIHSRSYTHIIRNIVNDPSV- 136 TLLD+IQG ++LLP E AF E++H++SY++I + + P + Sbjct: 70 FTGLTLLDTIQGTVGAISLLPDAETMHEEAVYTNIAFMESVHAKSYSNIFMTLASTPQIN 129 Query: 137 -VFDDIVTNEQIQKRAEGISSYYDELIEMTSYWHLLGEGTHTVNGKTVTVSLRELKKKLY 195 F NE +Q++A+ I SYY+ LKKK+ Sbjct: 130 EAFRWSEENENLQRKAKIIMSYYN--------------------------GDDPLKKKVA 163 Query: 196 LCLMSVNALEAIRFYVSFACSFAFAERELMEGNAKIIRLIARDEALHLTGTQHMLNLLRS 255 L LE+ FY F + R + A IIRLI RDE++H + Sbjct: 164 STL-----LESFLFYSGFYLPMYLSSRAKLTNTADIIRLIIRDESVHGYYIGYKYQQGVK 218 Query: 256 GADDPEMAEIAEECKQECYDLFVQAAQQEKDWADYLFRDGSMIGLNKDILCQYVEYITNI 315 + E EE K +DL + E ++ + ++ D +G +D+ +++ Y N Sbjct: 219 KLSEAE----QEEYKAYTFDLMYDLYENEIEYTEDIYDD---LGWTEDV-KRFLRYNANK 270 Query: 316 RMQAVGLDLPFQTRSNPI-PWINTWL---VSDNVQVAPQEVEVSSYLVGQIDSEVDTD 369 + +G + F T + P I + L +N SSY++G+ + D D Sbjct: 271 ALNNLGYEGLFPTDETKVSPAILSSLSPNADENHDFFSGS--GSSYVIGKAEDTTDDD 326 >2BQ1-I nrPDB Length = 319 Score = 289 bits (740), Expect = 1e-78, Method: Composition-based stats. Identities = 84/346 (24%), Positives = 134/346 (38%), Gaps = 51/346 (14%) Query: 30 DQQKYDIFEKLIEKQLSFFWRPEEVDVSRDRIDYQALPEHEKHIFISNLKYQTLLDSIQG 89 D + +++ +L S FW PE+V +S D +Q L E+ + I TLLD+IQ Sbjct: 16 DDKDLEVWNRLT----SNFWLPEKVPLSNDIPAWQTLSAAEQQLTIRVFTGLTLLDTIQN 71 Query: 90 RSPNVALLPLISIPELETWVETWAFSETIHSRSYTHIIRNIVNDPSV--VFDDIVTNEQI 147 + +L+ P E + +F E +H+RSY+ I + V + N + Sbjct: 72 IAGAPSLMADAITPHEEAVLSNISFMEAVHARSYSSIFSTLCQTKEVDAAYAWSEENPPL 131 Query: 148 QKRAEGISSYYDELIEMTSYWHLLGEGTHTVNGKTVTVSLRELKKKLYLCLMSVNALEAI 207 Q++A+ I ++Y VS LKKK+ LE+ Sbjct: 132 QRKAQIILAHY--------------------------VSDEPLKKKIASVF-----LESF 160 Query: 208 RFYVSFACSFAFAERELMEGNAKIIRLIARDEALHLTGTQHMLNLLRSGADDPEMAEIAE 267 FY F F+ R + A +IRLI RDEA+H + + E E Sbjct: 161 LFYSGFWLPMYFSSRGKLTNTADLIRLIIRDEAVHGYYIGYKYQIALQKLSAIE----RE 216 Query: 268 ECKQECYDLFVQAAQQEKDWADYLFRDGSMIGLNKDILCQYVEYITNIRMQAVGLDLPFQ 327 E K DL ++ E + + L+ + + K LC Y N + +G + F Sbjct: 217 ELKLFALDLLMELYDNEIRYTEALYAETGWVNDVKAFLC----YNANKALMNLGYEALFP 272 Query: 328 ---TRSNP-IPWINTWLVSDNVQVAPQEVEVSSYLVGQIDSEVDTD 369 NP I + +N SSY++G+ D D Sbjct: 273 PEMADVNPAILAALSPNADENHDFFSGS--GSSYVMGKTVETEDED 316 >3N37-A nrPDB Length = 319 Score = 288 bits (736), Expect = 3e-78, Method: Composition-based stats. Identities = 79/346 (22%), Positives = 131/346 (37%), Gaps = 51/346 (14%) Query: 30 DQQKYDIFEKLIEKQLSFFWRPEEVDVSRDRIDYQALPEHEKHIFISNLKYQTLLDSIQG 89 D + +++ +L S FW PE+V +S D +Q L E+ + + TLLD++Q Sbjct: 16 DDKDLEVWNRLT----SNFWLPEKVPLSNDIPAWQTLTVVEQQLTMRVFTGLTLLDTLQN 71 Query: 90 RSPNVALLPLISIPELETWVETWAFSETIHSRSYTHIIRNIV--NDPSVVFDDIVTNEQI 147 +L+P P E + +F E +H+RSY+ I + D + N + Sbjct: 72 VIGAPSLMPDALTPHEEAVLSNISFMEAVHARSYSSIFSTLCQTKDVDAAYAWSEENAPL 131 Query: 148 QKRAEGISSYYDELIEMTSYWHLLGEGTHTVNGKTVTVSLRELKKKLYLCLMSVNALEAI 207 Q++A+ I +Y LKKK+ LE+ Sbjct: 132 QRKAQIIQQHYR--------------------------GDDPLKKKIASVF-----LESF 160 Query: 208 RFYVSFACSFAFAERELMEGNAKIIRLIARDEALHLTGTQHMLNLLRSGADDPEMAEIAE 267 FY F F+ R + A +IRLI RDEA+H + + E Sbjct: 161 LFYSGFWLPMYFSSRGKLTNTADLIRLIIRDEAVHGYYIGYKYQKNMEKISLGQ----RE 216 Query: 268 ECKQECYDLFVQAAQQEKDWADYLFRDGSMIGLNKDILCQYVEYITNIRMQAVGLDLPFQ 327 E K +DL ++ E + D L+ + D + ++ Y N + +G + F Sbjct: 217 ELKSFAFDLLLELYDNELQYTDELYAETPW----ADDVKAFLCYNANKALMNLGYEPLFP 272 Query: 328 ---TRSNP-IPWINTWLVSDNVQVAPQEVEVSSYLVGQIDSEVDTD 369 NP I + +N SSY++G+ D D Sbjct: 273 AEMAEVNPAILAALSPNADENHDFFSGS--GSSYVMGKAVETEDED 316 >3MJO-A nrPDB Length = 296 Score = 285 bits (729), Expect = 2e-77, Method: Composition-based stats. Identities = 79/326 (24%), Positives = 136/326 (41%), Gaps = 50/326 (15%) Query: 22 QPVNVARY----DQQKYDIFEKLIEKQLSFFWRPEEVDVSRDRIDYQALPEHEKHIFISN 77 PV + D++ +++++L FW PE++ VS D + + E+ + Sbjct: 13 DPVKAINWNVIPDEKDLEVWDRLTGN----FWLPEKIPVSNDIQSWNKMTPQEQLATMRV 68 Query: 78 LKYQTLLDSIQGRSPNVALLPLISIPELETWVETWAFSETIHSRSYTHIIRNIVNDPSV- 136 TLLD+IQG ++LLP E AF E++H++SY++I + + P + Sbjct: 69 FTGLTLLDTIQGTVGAISLLPDAETMHEEAVYTNIAFMESVHAKSYSNIFMTLASTPQIN 128 Query: 137 -VFDDIVTNEQIQKRAEGISSYYDELIEMTSYWHLLGEGTHTVNGKTVTVSLRELKKKLY 195 F NE +Q++A+ I SYY+ LKKK+ Sbjct: 129 EAFRWSEENENLQRKAKIIMSYYN--------------------------GDDPLKKKVA 162 Query: 196 LCLMSVNALEAIRFYVSFACSFAFAERELMEGNAKIIRLIARDEALHLTGTQHMLNLLRS 255 L LE+ FY F + R + A IIRLI RDE++H + Sbjct: 163 STL-----LESFLFYSGFYLPMYLSSRAKLTNTADIIRLIIRDESVHGYYIGYKYQQGVK 217 Query: 256 GADDPEMAEIAEECKQECYDLFVQAAQQEKDWADYLFRDGSMIGLNKDILCQYVEYITNI 315 + E EE K +DL + E ++ + ++ D +G +D+ +++ Y N Sbjct: 218 KLSEAE----QEEYKAYTFDLMYDLYENEIEYTEDIYDD---LGWTEDV-KRFLRYNANK 269 Query: 316 RMQAVGLDLPFQTRSNPI-PWINTWL 340 + +G + F T + P I + L Sbjct: 270 ALNNLGYEGLFPTDETKVSPAILSSL 295 >4DR0-A nrPDB Length = 350 Score = 284 bits (727), Expect = 3e-77, Method: Composition-based stats. Identities = 70/349 (20%), Positives = 149/349 (42%), Gaps = 39/349 (11%) Query: 25 NVARYDQQKYDIFEKLIEKQLSFFWRPEEVDVSRDRIDYQALPEHEKHIFISNLKYQTLL 84 + A + + + D + + + FW PEE+ ++ D + ++ L ++E+ ++ L TLL Sbjct: 27 DAANWSKHEDDFTQMFYNQNVKQFWLPEEIALNGDLLTWKYLGKNEQDTYMKVLAGLTLL 86 Query: 85 DSIQGRSPNVALLPLISIPELETWVETWAFSET-IHSRSYTHIIRNIVNDPSV--VFDDI 141 D+ QG + + + + + + A E +H++SY++I + ++ VF+ + Sbjct: 87 DTEQGNTGMPIVAEHVDGHQRKAVLNFMAMMENAVHAKSYSNIFMTLAPTETINEVFEWV 146 Query: 142 VTNEQIQKRAEGISSYYDELIEMTSYWHLLGEGTHTVNGKTVTVSLRELKKKLYLCLMSV 201 N+ +QK+A+ I Y + ++ + L+ +++ Sbjct: 147 KQNKYLQKKAQMIVGLYKAI-------------------------QKDDEISLFKAMVAS 181 Query: 202 NALEAIRFYVSFACSFAFAERELMEGNAKIIRLIARDEALHLTGTQHMLNLLRSGADDPE 261 LE+ FY F F + + + +II LI RDEA+H + LL + + Sbjct: 182 VYLESFLFYSGFYYPLYFYGQGKLMQSGEIINLILRDEAIHGVY----VGLLAQEIYNKQ 237 Query: 262 MAEIAEECKQECYDLFVQAAQQEKDWADYLFRDGSMIGLNKDILCQYVEYITNIRMQAVG 321 E E ++ DL Q + E ++ + L+ +GL+ D+ +++ Y N + +G Sbjct: 238 TEEKKAELREFAIDLLNQLYENELEYTEDLY---DQVGLSHDV-KKFIRYNANKALMNLG 293 Query: 322 LDLPFQTRS-NPIPWINTWLVSDNVQVAPQEVEVSSYLVGQIDSEVDTD 369 D F+ NPI + + ++ + Y ++ D D Sbjct: 294 FDPYFEEEDINPIVLNGLNTKTKSHDFFS--MKGNGYKKATVEPLKDDD 340 >1UZR-A nrPDB Length = 296 Score = 284 bits (725), Expect = 6e-77, Method: Composition-based stats. Identities = 77/318 (24%), Positives = 133/318 (41%), Gaps = 52/318 (16%) Query: 24 VNVARY----DQQKYDIFEKLIEKQLSFFWRPEEVDVSRDRIDYQALPEHEKHIFISNLK 79 V+ + D++ +++++L FW PE+V VS D + L EK + + Sbjct: 11 VSAINWNRLQDEKDAEVWDRLTGN----FWLPEKVPVSNDIPSWGTLTAGEKQLTMRVFT 66 Query: 80 YQTLLDSIQGRSPNVALLPLISIPELETWVETWAFSETIHSRSYTHIIRNIVNDPSV--V 137 T+LD+IQG V+L+P P E + AF E++H++SY+ I + + + Sbjct: 67 GLTMLDTIQGTVGAVSLIPDALTPHEEAVLTNIAFMESVHAKSYSQIFSTLCSTAEIDDA 126 Query: 138 FDDIVTNEQIQKRAEGISSYYDELIEMTSYWHLLGEGTHTVNGKTVTVSLRELKKKLYLC 197 F N +Q++AE + Y LK+K+ Sbjct: 127 FRWSEENRNLQRKAEIVLQSYR--------------------------GDEPLKRKVAST 160 Query: 198 LMSVNALEAIRFYVSFACSFAFAERELMEGNAKIIRLIARDEALHLTGTQHMLNLLRSGA 257 L LE+ FY F ++ R + A +IRLI RDEA+H + + Sbjct: 161 L-----LESFLFYSGFYLPMYWSSRAKLTNTADMIRLIIRDEAVHGYYIGYKFQRGLALV 215 Query: 258 DDPEMAEIAEECKQECYDLFVQAAQQEKDWADYLFRDGSMIGLNKDILCQYVEYITNIRM 317 DD A E K Y+L + E ++ L+ + +GL +D+ +++ Y N + Sbjct: 216 DDVTRA----ELKDYTYELLFELYDNEVEYTQDLYDE---VGLTEDV-KKFLRYNANKAL 267 Query: 318 QAVGLDLPF---QTRSNP 332 +G + F +T NP Sbjct: 268 MNLGYEALFPRDETDVNP 285 >4BMQ-A nrPDB Length = 322 Score = 283 bits (723), Expect = 1e-76, Method: Composition-based stats. Identities = 78/354 (22%), Positives = 157/354 (44%), Gaps = 37/354 (10%) Query: 25 NVARYDQQKYDIFEKLIEKQLSFFWRPEEVDVSRDRIDYQALPEHEKHIFISNLKYQTLL 84 +++++ D ++ ++ FW EE+ VS D+ + L + E+ + L TLL Sbjct: 2 RAVNWNKKEDDFSLMFWKQNIAQFWTEEEIAVSSDKNTWVQLSKEEQIAYKRVLGGLTLL 61 Query: 85 DSIQGRSPNVALLPLISIPELETWVETWAFSETIHSRSYTHIIRNIVNDPSV--VFDDIV 142 D+ QG +L + + ++ + E +H++SY+HI + + + +FD + Sbjct: 62 DTKQGGEGMPLVLVHLENLQAKSVLAFMGAMEEVHAKSYSHIFTTLATEEEIDDIFDWVD 121 Query: 143 TNEQIQKRAEGISSYYDELIEMTSYWHLLGEGTHTVNGKTVTVSLRELKKKLYLCLMSVN 202 + ++K+A I+SYY L++ KK+LY+ +++ Sbjct: 122 NHPLLEKKAGIITSYYRRLLKP-----------------------EVTKKELYMAMVASV 158 Query: 203 ALEAIRFYVSFACSFAFAERELMEGNAKIIRLIARDEALHLTGTQHMLNLLRSGADDPEM 262 LE+ FY F A + + + +II LI RDE++H + +L Sbjct: 159 FLESYLFYSGFFYPLYLAGQGKLTASGEIINLIIRDESIHGVF----VGILAQQIFAELS 214 Query: 263 AEIAEECKQECYDLFVQAAQQEKDWADYLFRDGSMIGLNKDILCQYVEYITNIRMQAVGL 322 AE +E ++E +L ++ + E + + ++ + IGL +D+ ++V Y N + +GL Sbjct: 215 AEEQQEVQKETQELLMELYEIEMAYTEEIY---TSIGLVEDV-NRFVRYNANKGLMNLGL 270 Query: 323 DLPFQTRS-NPIPWINTWLVSDNVQVAPQEVEVSSYLVG-QIDSEVDTDDLSNF 374 + F+ NPI + N V+ + Y+ ++ D D + NF Sbjct: 271 EPKFEEEEINPIVLNGLRTDTKNHDFFS--VKGNGYVKATNVEKLADDDFVFNF 322 >4N83-A nrPDB Length = 319 Score = 279 bits (713), Expect = 1e-75, Method: Composition-based stats. Identities = 78/350 (22%), Positives = 136/350 (38%), Gaps = 46/350 (13%) Query: 25 NVARYDQQKYDIFEKLIEKQLSFFWRPEEVDVSRDRIDYQALPEHEKHIFISNLKYQTLL 84 ++ + I + EK FW + +S D D++ L EK + TLL Sbjct: 6 KAINWNAIEDVIDKSTWEKLTEQFWLDTRIPLSNDLDDWRKLSHKEKDLVGKVFGGLTLL 65 Query: 85 DSIQGRSPNVALLPLISIPELETWVETWAFSETIHSRSYTHIIRNIVNDPSV--VFDDIV 142 D++Q S AL + E F E++H++SY+ I + + +F Sbjct: 66 DTLQSESGVDALRKDVRTAHEEAVFNNIQFMESVHAKSYSSIFSTLNTKSEIDEIFAWTN 125 Query: 143 TNEQIQKRAEGISSYYDELIEMTSYWHLLGEGTHTVNGKTVTVSLRELKKKLYLCLMSVN 202 TN +QK+AE I+ Y ++ L+KK+ Sbjct: 126 TNPYLQKKAEIINEIY--------------------------LNGTALEKKIASVF---- 155 Query: 203 ALEAIRFYVSFACSFAFAERELMEGNAKIIRLIARDEALHLTGTQHMLNLLRSGADDPEM 262 LE FY F + + A+II+LI RDE++H T + L + + E Sbjct: 156 -LETFLFYSGFFTPLYYLGNNKLANVAEIIKLIIRDESVHGTYIGYKFQLAFNELPEDE- 213 Query: 263 AEIAEECKQECYDLFVQAAQQEKDWADYLFRDGSMIGLNKDILCQYVEYITNIRMQAVGL 322 E+ K+ YDL + E+ + + L+ +G +++ ++ Y N + +G Sbjct: 214 ---QEKLKEWMYDLLYTLYENEEGYTESLY---DTVGWTEEV-KTFLRYNANKALMNLGQ 266 Query: 323 DLPFQ---TRSNPIPWINTWLVSDNVQVAPQEVEVSSYLVGQIDSEVDTD 369 D F NPI + N Q + YL+G++++ D D Sbjct: 267 DPLFPDSADDVNPIVMNGISTGTSNHDFFSQ--VGNGYLLGEVEAMQDDD 314 >2O1Z-A nrPDB Length = 311 Score = 272 bits (696), Expect = 1e-73, Method: Composition-based stats. Identities = 70/332 (21%), Positives = 135/332 (40%), Gaps = 49/332 (14%) Query: 10 KNDQLKEPMFFGQPVNVARYDQQKYDIFEKLIEKQLSFFWRPEEVDVSRDRIDYQALPEH 69 K+ + E + + Y D+++ +K + FW EE+D+S D D++ L ++ Sbjct: 24 KSKEANEKILSKETDRFTLYPILYPDVWD-FYKKAEASFWTAEEIDLSSDLKDFEKLNDN 82 Query: 70 EKHIFISNLKYQTLLDSIQGRSPNVALLPLISIPELETWVETWAFSETIHSRSYTHIIRN 129 EKH L + D I + L + I E + + E IHS +Y+ +I N Sbjct: 83 EKHFIKHVLAFFAASDGIVLENLASKFLRQVKITEAKKFYAFQIAVENIHSETYSLLIDN 142 Query: 130 IVNDPSV---VFDDIVTNEQIQKRAEGISSYYDELIEMTSYWHLLGEGTHTVNGKTVTVS 186 + D +F I ++ +A + + ++ T++ + V + Sbjct: 143 YIKDEKERMNLFHAIENIPAVKNKALWAAKWIND--------------TNSFAERIVANA 188 Query: 187 LRELKKKLYLCLMSVNALEAIRFYVSFACSFAFAERELMEGNAKIIRLIARDEALHLTGT 246 +E I F SF F F ++ + G LI+RDE LH Sbjct: 189 ----------------CVEGILFSGSFCAIFWFKKQNKLHGLTFSNELISRDEGLHTDFN 232 Query: 247 QHMLNLLRSGADDPEMAEIAEECKQECYDLFVQAAQQEKDW-ADYLFRDGSMIGLNKDIL 305 + +LL + + + I +E A + E+ + + L D +IG+N ++ Sbjct: 233 CLIYSLLENKLPEEVVQNIVKE-----------AVEVERSFICESLPCD--LIGMNSRLM 279 Query: 306 CQYVEYITNIRMQAVGLDLPFQTRSNPIPWIN 337 QY+E++ + ++ +G F + NP W++ Sbjct: 280 SQYIEFVADRLLECLGSPKIFHAK-NPFNWMD 310 >2P1I-A nrPDB Length = 349 Score = 270 bits (690), Expect = 7e-73, Method: Composition-based stats. Identities = 70/347 (20%), Positives = 137/347 (39%), Gaps = 49/347 (14%) Query: 10 KNDQLKEPMFFGQPVNVARYDQQKYDIFEKLIEKQLSFFWRPEEVDVSRDRIDYQALPEH 69 K+ + E + + + +++ +K + FW EE+D+S D D++ L + Sbjct: 25 KSKESNEKILNKESNRFTLHPIMYPEVWN-FYKKAEASFWTAEEIDLSSDLKDFEKLNVN 83 Query: 70 EKHIFISNLKYQTLLDSIQGRSPNVALLPLISIPELETWVETWAFSETIHSRSYTHIIRN 129 EKH L + D I + L + I E + + E IHS +Y+ +I N Sbjct: 84 EKHFIKHVLAFFAASDGIVLENLASKFLREVEIIEAKKFYSFQIAVENIHSETYSLLIDN 143 Query: 130 IVNDPSV---VFDDIVTNEQIQKRAEGISSYYDELIEMTSYWHLLGEGTHTVNGKTVTVS 186 + D +F I I+ +A + + ++ T++ + V + Sbjct: 144 YIKDEKERLNLFHAIENIPAIKNKALWAAKWIND--------------TNSFAERIVANA 189 Query: 187 LRELKKKLYLCLMSVNALEAIRFYVSFACSFAFAERELMEGNAKIIRLIARDEALHLTGT 246 +E I F SF F F ++ + G LI+RDE LH Sbjct: 190 ----------------CVEGILFSGSFCAIFWFKKQNKLHGLTFSNELISRDEGLHTDFN 233 Query: 247 QHMLNLLRSGADDPEMAEIAEECKQECYDLFVQAAQQEKDW-ADYLFRDGSMIGLNKDIL 305 + +LL + + + I +E A + E+ + + L D +IG+N ++ Sbjct: 234 CLIYSLLENKLPENVVQNIVKE-----------AVEVERSFICESLPCD--LIGMNSRLM 280 Query: 306 CQYVEYITNIRMQAVGLDLPFQTRSNPIPWINTWLVSDNVQVAPQEV 352 QY+E++ + ++ +G F ++ NP W++ + + V Sbjct: 281 SQYIEFVADRLLECLGCSKVFHSK-NPFNWMDLISLQGKTNFFEKRV 326 >6GP2-A nrPDB Length = 345 Score = 269 bits (686), Expect = 2e-72, Method: Composition-based stats. Identities = 76/362 (20%), Positives = 138/362 (38%), Gaps = 59/362 (16%) Query: 20 FGQPVNVARY----DQQKYDIFEKLIEKQLSFFWRPEEVDVSRDRIDYQALPEHEKHIFI 75 F + + D++ +++ ++ + FW PE++ VS D ++ L + + Sbjct: 28 FKGKMRSVNWNVVNDEKDLEVWNRITQN----FWLPEKIPVSNDLTSWRTLTPEWQELIT 83 Query: 76 SNLKYQTLLDSIQGRSPNVALLPLISIPELETWVETWAFSETIHSRSYTHIIRNIVNDPS 135 TLLD+IQ +VA +P + +AF +H+RS+ I + + Sbjct: 84 RTFTGLTLLDTIQATVGDVAQVPNSLTDHEQVIYTNFAFMVAVHARSFGSIFSTLCSSEQ 143 Query: 136 V--VFDDIVTNEQIQKRAEGISSYYDELIEMTSYWHLLGEGTHTVNGKTVTVSLRELKKK 193 + + ++ E +Q+RA+ + YY V+ LK K Sbjct: 144 IEEAHEWVINTETLQERAKALIPYY--------------------------VNDDPLKSK 177 Query: 194 LYLCLMSVNALEAIRFYVSFACSFAFAERELMEGNAKIIRLIARDEALH--LTGTQHMLN 251 + LM Y F F + R + + IIRLI RD+ +H +G ++ Sbjct: 178 VAAALMP-----GFLLYGGFYLPFYLSARGKLPNTSDIIRLILRDKVIHNYYSGYKYQKK 232 Query: 252 LLRSGADDPEMAEIAEECKQECYDLFVQAAQQEKDWADYLFRDGSMIGLNKDILCQYVEY 311 + + E E K+ + L + EK + L+ D + D ++ Y Sbjct: 233 VAKLSP------EKQAEMKEFVFKLLYELIDLEKAYLKELYEDFGL----ADDAIRFSVY 282 Query: 312 ITNIRMQAVGLDLPF---QTRSNPIPWINTWLVSD-NVQVAPQEVEVSSYLVGQIDSEVD 367 +Q +G D PF +TR P + +D N SSY++G + D Sbjct: 283 NAGKFLQNLGYDSPFTEEETRIEPEIFTQLSARADENHDFFSGN--GSSYIMGVSEETED 340 Query: 368 TD 369 D Sbjct: 341 DD 342 >1SMQ-A nrPDB Length = 399 Score = 268 bits (685), Expect = 2e-72, Method: Composition-based stats. Identities = 69/349 (19%), Positives = 139/349 (39%), Gaps = 47/349 (13%) Query: 8 QTKNDQLKEPMFFGQPVNVARYDQQKYDIFEKLIEKQLSFFWRPEEVDVSRDRIDYQA-L 66 + K + +EP+ + + ++I++ ++ + FW EE+D+S+D D+ + Sbjct: 68 KLKEMEKEEPLLNEDKERTVLFPIKYHEIWQA-YKRAEASFWTAEEIDLSKDIHDWNNRM 126 Query: 67 PEHEKHIFISNLKYQTLLDSIQGRSPNVALLPLISIPELETWVETWAFSETIHSRSYTHI 126 E+E+ L + D I + + IPE +++ E IHS +Y+ + Sbjct: 127 NENERFFISRVLAFFAASDGIVNENLVENFSTEVQIPEAKSFYGFQIMIENIHSETYSLL 186 Query: 127 IRNIVNDPS---VVFDDIVTNEQIQKRAEGISSYYDELIEMTSYWHLLGEGTHTVNGKTV 183 I + DP +F+ I T +I ++AE + + + Sbjct: 187 IDTYIKDPKESEFLFNAIHTIPEIGEKAEWALRWIQDADALFGER--------------- 231 Query: 184 TVSLRELKKKLYLCLMSVNALEAIRFYVSFACSFAFAERELMEGNAKIIRLIARDEALHL 243 L++ ++E + F SFA F +R +M G LI RDE LH Sbjct: 232 --------------LVAFASIEGVFFSGSFASIFWLKKRGMMPGLTFSNELICRDEGLHT 277 Query: 244 TGTQHMLNLLRSGADDPEMAEIAEECKQECYDLFVQAAQQEKDWADYLFRDGSMIGLNKD 303 + L++ D + +I E A + E+ + +++G+N D Sbjct: 278 DFACLLFAHLKNKPDPAIVEKIVTE-----------AVEIEQRYFLDALP-VALLGMNAD 325 Query: 304 ILCQYVEYITNIRMQAVGLDLPFQTRSNPIPWINTWLVSDNVQVAPQEV 352 ++ QYVE++ + + A G ++ NP ++ ++ + V Sbjct: 326 LMNQYVEFVADRLLVAFGNKKYYKV-ENPFDFMENISLAGKTNFFEKRV 373 >6EBP-A nrPDB Length = 355 Score = 265 bits (676), Expect = 3e-71, Method: Composition-based stats. Identities = 74/360 (20%), Positives = 136/360 (37%), Gaps = 59/360 (16%) Query: 22 QPVNVARY----DQQKYDIFEKLIEKQLSFFWRPEEVDVSRDRIDYQALPEHEKHIFISN 77 Q + + D++ +++ ++ + FW PE + VS D + L + + + Sbjct: 40 QNMRAINWNKIVDEKDLEVWNRVTQN----FWLPENIPVSNDLPSWNELDDDWQQLITRT 95 Query: 78 LKYQTLLDSIQGRSPNVALLPLISIPELETWVETWAFSETIHSRSYTHIIRNIVNDPSV- 136 TLLD++Q +VA + + + +AF +H+RS+ I + + Sbjct: 96 FTGLTLLDTVQSSIGDVAQIKNSLTEQEQVIYANFAFMVGVHARSFGTIFSTLCTSEQIE 155 Query: 137 -VFDDIVTNEQIQKRAEGISSYYDELIEMTSYWHLLGEGTHTVNGKTVTVSLRELKKKLY 195 + +V NE +Q R + + +Y + LK K+ Sbjct: 156 EAHEWVVDNEALQARPKALIPFY--------------------------TADDPLKSKIA 189 Query: 196 LCLMSVNALEAIRFYVSFACSFAFAERELMEGNAKIIRLIARDEALH--LTGTQHMLNLL 253 LM Y F F + R + + IIRLI RD+ +H +G ++ L + Sbjct: 190 AALMP-----GFLLYGGFYLPFYLSARGKLPNTSDIIRLILRDKVIHNFYSGYKYQLKVA 244 Query: 254 RSGADDPEMAEIAEECKQECYDLFVQAAQQEKDWADYLFRDGSMIGLNKDILCQYVEYIT 313 + E E KQ +DL + EK + L+ + D ++ Y Sbjct: 245 KLSP------EKQAEMKQFVFDLLDKMIGLEKTYLHQLYDGFGL----ADEAIRFSLYNA 294 Query: 314 NIRMQAVGLDLPF---QTRSNPIPWINTWLVSD-NVQVAPQEVEVSSYLVGQIDSEVDTD 369 +Q +G + PF +TR P + +D N SSY++G + +D D Sbjct: 295 GKFLQNLGYESPFTKEETRIAPEVFAQLSARADENHDFFSGS--GSSYIIGTSEETLDED 352 >2RCC-A nrPDB Length = 346 Score = 245 bits (625), Expect = 2e-65, Method: Composition-based stats. Identities = 77/339 (22%), Positives = 148/339 (43%), Gaps = 35/339 (10%) Query: 18 MFFGQPVNVARYDQQKYDIFEKLIEKQLSFFWRPEEVDVSRDRIDYQALPEHEKHIFISN 77 + G+ NV +D ++ L + L+ FW P E+++S D + L E E+ F Sbjct: 22 ILNGKSSNVLNWDDVRFSWAYPLYKNMLANFWTPFEINMSHDAKQFPTLTETEQEAFKKI 81 Query: 78 LKYQTLLDSIQGRSPNVALLPLISIPELETWVETWAFSETIHSRSYTHIIRNIVN--DPS 135 + LDS+Q ++ ++ L + +F E +H++SY++++ ++V Sbjct: 82 IGLLAFLDSVQ-TDYSMRAAEYLTDSSLAALMSVLSFQEVVHNQSYSYVLSSLVPKATQD 140 Query: 136 VVFDDIVTNEQIQKRAEGISSYYDELIEMTSYWHLLGEGTHTVNGKTVTVSLRELKKKLY 195 +F+ ++ +++R E I Y++ ++ + L + V Sbjct: 141 EIFEYWKHDDVLKERNEFIIDGYEKFVDNPTPKTFLESIVYDV----------------- 183 Query: 196 LCLMSVNALEAIRFYVSFACSFAFAERELMEGNAKIIRLIARDEALHLTGTQHMLNLLRS 255 LE + FY FA + A + M + +I I RDE LH+ ++ L Sbjct: 184 -------ILEGLNFYSGFAFFYNLARNQKMVSTSTMINYINRDEQLHVYLFTNIFKELL- 235 Query: 256 GADDPEMAEIAEECKQECYDLFVQAAQQEKDWADYLFRDGSMIGLNKDILCQYVEYITNI 315 + PE+ EE K ++AA EKDW Y+ D + G+N + + Y+ +I N Sbjct: 236 -VEFPELN--TEETKTFVKTTLMKAADLEKDWFRYIIGD-KIPGINPEDMETYISFIANK 291 Query: 316 RMQAVGLDLPF-QTRSNPIPWINTW--LVSDNVQVAPQE 351 R +G++ P+ + + NP+ WI + + S Q+ Sbjct: 292 RAVQLGMEKPYPEIKHNPMKWIRAYEDVNSGKSDFFEQK 330 >4M1I-A nrPDB Length = 366 Score = 244 bits (622), Expect = 5e-65, Method: Composition-based stats. Identities = 74/307 (24%), Positives = 144/307 (46%), Gaps = 24/307 (7%) Query: 33 KYDIFEKLIEKQLSFFWRPEEVDVSRDRIDYQA--LPEHEKHIFISNLKYQTLLDSIQGR 90 KY + + W P E+ + +D +++ L E E+ + + NL + + +S+ G Sbjct: 55 KYKWAWEHYLNGCANNWLPTEIPMGKDIELWKSDRLSEDERRVILLNLGFFSTAESLVGN 114 Query: 91 SPNVALLPLISIPELETWVETWAFSETIHSRSYTHIIRNIVNDPSVVFDDIVTNEQIQKR 150 + +A+ ++ PE ++ AF E +H+ ++ +I ++ D +F+ NE+ + Sbjct: 115 NIVLAIFKHVTNPEARQYLLRQAFEEAVHTHTFLYICESLGLDEKEIFNA--YNERAAIK 172 Query: 151 AEGISSYYDELIEMTSYWHLLGEGTHTVNGKTVTVSLRELKKKLYLCLMSVNALEAIRFY 210 A+ D +E+T T +V G L+E K L + +E I FY Sbjct: 173 AKD-----DFQMEITGKVLDPNFRTDSVEG------LQEFVKNLVGYYI---IMEGIFFY 218 Query: 211 VSFACSFAFAERELMEGNAKIIRLIARDEALHLTGTQHMLNLLRSGADDPEMAEIAEECK 270 F +F + M G + + I RDE +HL ++N ++ ++PE+ E + Sbjct: 219 SGFVMILSFHRQNKMIGIGEQYQYILRDETIHLNFGIDLINGIKE--ENPEIW--TPELQ 274 Query: 271 QECYDLFVQAAQQEKDWADYLFRDGSMIGLNKDILCQYVEYITNIRMQAVGLDLPFQTRS 330 QE +L +A E ++A G ++GL + YV++I + R++ +GL + T+ Sbjct: 275 QEIVELIKRAVDLEIEYAQDCLPRG-ILGLRASMFIDYVQHIADRRLERIGLKPIYHTK- 332 Query: 331 NPIPWIN 337 NP PW++ Sbjct: 333 NPFPWMS 339 >1SMS-A nrPDB Length = 345 Score = 172 bits (436), Expect = 2e-43, Method: Composition-based stats. Identities = 54/347 (15%), Positives = 124/347 (35%), Gaps = 45/347 (12%) Query: 8 QTKNDQLKEPMFFGQPVNVARYDQQKYDIFEKLIEKQLSFFWRPEEVDVSRDRIDYQALP 67 K + E + + + ++I+ +K + FW EE+++++D D+Q L Sbjct: 17 DMKEAEKDEILLMENSRRFVMFPIKYHEIWAA-YKKVEASFWTAEEIELAKDTEDFQKLT 75 Query: 68 EHEKHIFISNLKYQTLLDSIQGRSPNVALLPLISIPELETWVETWAFSETIHSRSYTHII 127 + +K + L D++ + + PE +++ E I+S Y+ ++ Sbjct: 76 DDQKTYIGNLLALSISSDNLVNKYLIENFSAQLQNPEGKSFYGFQIMMENIYSEVYSMMV 135 Query: 128 RNIVNDPSVV--FDDIVTNEQIQKRAEGISSYYDELIEMTSYWHLLGEGTHTVNGKTVTV 185 DP + F +I +++ +A I + Sbjct: 136 DAFFKDPKNIPLFKEIANLPEVKHKAAFIERWISN------------------------- 170 Query: 186 SLRELKKKLYLCLMSVNALEAIRFYVSFACSFAFAERELMEGNAKIIRLIARDEALHLTG 245 L++ A E I ++A F ++++M G A R I RD + Sbjct: 171 ----DDSLYAERLVAFAAKEGIFQAGNYASMFWLTDKKIMPGLAMANRNICRDRGAYTDF 226 Query: 246 TQHMLNLLRSGADDPEMAEIAEECKQECYDLFVQAAQQEKDWADYLFRDGSMIGLNKDIL 305 + + LR+ + + +I +A + EK++ G++ + Sbjct: 227 SCLLFAHLRTKPNPKIIEKI-----------ITEAVEIEKEYYSNSLPVEK-FGMDLKSI 274 Query: 306 CQYVEYITNIRMQAVGLDLPFQTRSNPIPWINTWLVSDNVQVAPQEV 352 Y+E++ + +Q G + + NP ++ + ++V Sbjct: 275 HTYIEFVADGLLQGFGNEKYYNA-VNPFEFMEDVATAGKTTFFEKKV 320 >5OLK-A nrPDB Length = 430 Score = 78.0 bits (190), Expect = 6e-15, Method: Composition-based stats. Identities = 43/290 (14%), Positives = 111/290 (38%), Gaps = 41/290 (14%) Query: 47 FFWRPEEVDVSRDRIDYQA-LPEHEKHIFISNLKYQTLLDSIQGRSPNVALLPLIS---- 101 +W E + + D D++ L E E+ + T+L Q + Sbjct: 134 SYWIHTEFNFTSDIQDFKTGLSEVERSAIKN-----TMLAISQIEVAVKTFWGDVHHRLP 188 Query: 102 IPELETWVETWAFSETIHSRSYTHIIRNIVNDPSVVFDDIVTNEQIQKRAEGISSYYDEL 161 PE+ T+A SE H +Y+H++ + + ++++K+ Sbjct: 189 KPEIAAVGATFAESEVRHHDAYSHLLEILGLNEEF--------KELKKKP---------- 230 Query: 162 IEMTSYWHLLGEGTHTVNGKTVTVSLRELKKKLYLCLMSVNALEAIRFYVSFACSFAFAE 221 ++ + H + + ++ L+ +E + + F AF + Sbjct: 231 --------VIMKRVHYLETSLKHAKSDDDREYTESILLFALFIEHVSLFSQFLIIMAFNK 282 Query: 222 -RELMEGNAKIIRLIARDEALHLTGTQHMLNLLRSGADDPEMAEIAEECKQECYDLFVQA 280 + +++G + + +++E +H ++N+++ + EE ++ + + Sbjct: 283 HKNMLKGISNAVEATSKEEQIHGDFGVDIINIIKKENPE----WFDEEHNNLIKEMCLNS 338 Query: 281 AQQEKDWADYLFRDGSMIGLNKDILCQYVEYITNIRMQAVGLDLPFQTRS 330 + E D++F G + L K ++ ++++ N ++A+GL+ F Sbjct: 339 FEAESKVVDWIFEKGELDFLPKAVINEFLKNRFNKSLEAIGLEKLFDIDE 388 >6QRZ-A nrPDB Length = 328 Score = 76.9 bits (187), Expect = 1e-14, Method: Composition-based stats. Identities = 48/283 (16%), Positives = 104/283 (36%), Gaps = 37/283 (13%) Query: 39 KLIEKQLSFFWRPEEVDVSRDRIDYQALPEHEKHIFISNLKYQTLLDSIQGRSPNVALLP 98 KL + FW P ++D S+D+ D++ L + EK+ ++ + + + Sbjct: 47 KLYQIGKRLFWDPAKIDFSKDKEDWKKLSKDEKNYLLNIVSLFMAGEEAVAVDITPLIST 106 Query: 99 LISIPELETW--VETWAFSETIHSRSYTHIIRNIVNDPSVVFDDIVTNEQIQKRAEGISS 156 +I+ +E +E +AF E H+ ++ ++ + + N QK Sbjct: 107 MINEGRVEDVIYLEQFAFEEAKHAEAFRRFCDSLEINDDLTIFTTEYNPWYQK------I 160 Query: 157 YYDELIEMTSYWHLLGEGTHTVNGKTVTVSLRELKKKLYLCLMSVN-ALEAIRFYVSFAC 215 +Y+EL + + + + L + + + N +E + + Sbjct: 161 FYEELPSVMWK-----------------LRVDPSPENLAVAVTTYNLYVEGVAAESGYKT 203 Query: 216 SFA-FAERELMEGNAKIIRLIARDEALHLTGTQHMLNLLRSGADDPEMAEIAEECKQECY 274 F +M G +K + LIA DE+ H+ +++ L + E E ++ Sbjct: 204 FKHIFNSLNIMPGLSKTVNLIATDESRHIAYGTYLITRL--------IVENGESIYRKAI 255 Query: 275 DLFVQAAQQEKDWADYLFRDGSMIGLNKDILCQYVEYITNIRM 317 + F + + L GL D + + + N R+ Sbjct: 256 EQFNKLVGIVQSLTRPL--AKLPFGLTPDFTIENRKQLVNARL 296 >4AC8-A nrPDB Length = 323 Score = 73.8 bits (179), Expect = 1e-13, Method: Composition-based stats. Identities = 53/320 (16%), Positives = 108/320 (33%), Gaps = 48/320 (15%) Query: 39 KLIEKQLSFFWRPEEVDVSRDRIDYQALPEHEKHIFISNLKYQTLLDSIQGRSPNV--AL 96 KL + FW P ++D +RDR D++ L + E+ + + Sbjct: 31 KLFAGGNAKFWHPADIDFTRDRADWEKLSDDERDYATRLCTQFIAGEEAVTEDIQPFMSA 90 Query: 97 LPLISIPELETWVETWAFSETIHSRSYTHIIRNIVNDPSVVFDDIVTNEQIQKRAEGISS 156 + E ++ +AF E H++ + + + + + + Sbjct: 91 MRAEGRLADEMYLTQFAFEEAKHTQVFRMWLDAVGISEDL-------HRYLDDLPAYRQI 143 Query: 157 YYDELIEMTSYWHLLGEGTHTVNGKTVTVSLRELKKKLYLCLMSVNALEAIRFYVSFACS 216 +Y EL E + + ++ + + +E + + Sbjct: 144 FYAELPECLN----------------ALSADPSPAAQVRASVTYNHIVEGMLALTGYYA- 186 Query: 217 FAFA---ERELMEGNAKIIRLIARDEALHLTGTQHMLNLLRSGADDPEMAEIAEECKQEC 273 ER ++ G +++R I DE H+ R A D + E E Sbjct: 187 -WHKICVERAILPGMQELVRRIGDDERRHMAWGT--FTCRRHVAADDANWTVFETRMNEL 243 Query: 274 YDLFVQAAQQEKDWADYLFRDGSMIGLNKDILCQYVEYITNIRMQAVGLDLPFQTRSNPI 333 L ++ E+ +A L+ D L+KD +++Y T+ M+ G R P+ Sbjct: 244 IPLALRL--IEEGFA--LYGDQPPFDLSKD---DFLQYSTDKGMRRFG--TISNARGRPV 294 Query: 334 PWINTWLVSDNVQVAPQEVE 353 I+ V +P ++E Sbjct: 295 AEID-------VDYSPAQLE 307 >6CWO-A nrPDB Length = 344 Score = 73.4 bits (178), Expect = 2e-13, Method: Composition-based stats. Identities = 48/309 (15%), Positives = 111/309 (35%), Gaps = 34/309 (11%) Query: 30 DQQKYDIFEKLIEKQLSFFWRPEEVDVSRDRIDYQA-LPEHEKHIFISNLKYQTLLDSIQ 88 + ++ + E +W EVD + D D+ A L EK ++L ++ Sbjct: 32 PFEYPEVLQ-FTEAINKAYWVHTEVDFTADTQDFHAHLSLAEKTAVKNSLLAIAQIEVAV 90 Query: 89 GRSPNVALLPLISIPELETWVETWAFSETIHSRSYTHIIRNIVNDPSVVFDDIVTNEQIQ 148 +S + PE T+A E HS +Y+ ++ + Sbjct: 91 -KSFWGNIYEHFPKPEFNGLGSTFAECEFRHSEAYSRLLEVL------------------ 131 Query: 149 KRAEGISSYYDELIEMTSYWHLLGEGTHTVNGKTVTVSLRELKKKLYLCLMSVNALEAIR 208 Y++ E ++ ++ ++ +K + ++ +E + Sbjct: 132 --------GYNDEFEKLLDVPVIRRRVDYLSNVLKDTKSQDNRKYMVSLILFSILIENVS 183 Query: 209 FYVSFACSFAFAE-RELMEGNAKIIRLIARDEALHLTGTQHMLNLLRSGADDPEMAEIAE 267 + FA +F + M+ + II + DE +H G +++N +R D E Sbjct: 184 LFSQFAILLSFTRFKGYMKNVSNIIAWTSIDEQIHANGGIYIINKIREEFPD----YFDE 239 Query: 268 ECKQECYDLFVQAAQQEKDWADYLFRDGSMIGLNKDILCQYVEYITNIRMQAVGLDLPFQ 327 E + + E D D++F +G + + K L ++++ + ++ + + + F Sbjct: 240 ETLALVRETVKDSIAVESDILDWIFEEGEIESIKKGDLVNFMKFRIDESLKQINIPVIFD 299 Query: 328 TRSNPIPWI 336 + + Sbjct: 300 VKVEDYKAL 308 >6CWP-A nrPDB Length = 307 Score = 73.0 bits (177), Expect = 2e-13, Method: Composition-based stats. Identities = 48/309 (15%), Positives = 111/309 (35%), Gaps = 34/309 (11%) Query: 30 DQQKYDIFEKLIEKQLSFFWRPEEVDVSRDRIDYQA-LPEHEKHIFISNLKYQTLLDSIQ 88 + ++ + E +W EVD + D D+ A L EK ++L ++ Sbjct: 19 PFEYPEVLQ-FTEAINKAYWVHTEVDFTADTQDFHAHLSLAEKTAVKNSLLAIAQIEVAV 77 Query: 89 GRSPNVALLPLISIPELETWVETWAFSETIHSRSYTHIIRNIVNDPSVVFDDIVTNEQIQ 148 +S + PE T+A E HS +Y+ ++ + Sbjct: 78 -KSFWGNIYEHFPKPEFNGLGSTFAECEFRHSEAYSRLLEVL------------------ 118 Query: 149 KRAEGISSYYDELIEMTSYWHLLGEGTHTVNGKTVTVSLRELKKKLYLCLMSVNALEAIR 208 Y++ E ++ ++ ++ +K + ++ +E + Sbjct: 119 --------GYNDEFEKLLDVPVIRRRVDYLSNVLKDTKSQDNRKYMVSLILFSILIENVS 170 Query: 209 FYVSFACSFAFAE-RELMEGNAKIIRLIARDEALHLTGTQHMLNLLRSGADDPEMAEIAE 267 + FA +F + M+ + II + DE +H G +++N +R D E Sbjct: 171 LFSQFAILLSFTRFKGYMKNVSNIIAWTSIDEQIHANGGIYIINKIREEFPD----YFDE 226 Query: 268 ECKQECYDLFVQAAQQEKDWADYLFRDGSMIGLNKDILCQYVEYITNIRMQAVGLDLPFQ 327 E + + E D D++F +G + + K L ++++ + ++ + + + F Sbjct: 227 ETLALVRETVKDSIAVESDILDWIFEEGEIESIKKGDLVNFMKFRIDESLKQINIPVIFD 286 Query: 328 TRSNPIPWI 336 + + Sbjct: 287 VKVEDYKAL 295 >5OMK-A nrPDB Length = 316 Score = 58.4 bits (139), Expect = 5e-09, Method: Composition-based stats. Identities = 34/280 (12%), Positives = 82/280 (29%), Gaps = 27/280 (9%) Query: 33 KYDIFEKLIEKQLSFFWRPEEVDVSRDRIDYQALPEHEKHIFISNLKYQTLLDSIQGRSP 92 ++ +F+ + + + W P ++D S+D+ D+ +L EK + + + + Sbjct: 31 EHPMFKLYEKAKRNGKWNPADIDFSQDQKDFASLTSEEKISALPLVAGFSAGEEAVTLDI 90 Query: 93 NVALLPLISIPELETWVETWAFS--ETIHSRSYTHIIRNIVNDPSVVFDDIVTNEQIQKR 150 L LE + F E H ++ ++ Sbjct: 91 LPMAHALARQGRLEDVLFLTTFMHDEAKHVEMFS--------------RW--------QQ 128 Query: 151 AEGISSYYDELIEMTSYWHLLGEGTHTVNGKTVTVSLRELKKKLYLCLMSVNALEAIRFY 210 A GI + Y + E + + + + + +E Sbjct: 129 AVGIGQMDLSVFHNDHYKRIFYEALPEAMNRL--YADDSPEAVIRAATVYNMIVEGTLAE 186 Query: 211 VSFACSFA-FAERELMEGNAKIIRLIARDEALHLTGTQHMLNLLRSGADDPEMAEIAEEC 269 + + + L G + I + DE H+ + + + + + I Sbjct: 187 SGYYTFRQIYKKAGLFPGLLQGIDYLNMDEGRHIQFGIYTIQRIVNEDERYYELFIRYMD 246 Query: 270 KQECYDLFVQAAQQEKDWADYLFRDGSMIGLNKDILCQYV 309 + + + E + ++ D+L YV Sbjct: 247 ELWPHVIGYVDYLTELGKRQQQLARTYALEIDYDLLRHYV 286 >5XIL-A nrPDB Length = 512 Score = 31.4 bits (69), Expect = 0.61, Method: Composition-based stats. Identities = 6/61 (9%), Positives = 19/61 (31%) Query: 97 LPLISIPELETWVETWAFSETIHSRSYTHIIRNIVNDPSVVFDDIVTNEQIQKRAEGISS 156 + +T A E +H++ Y + V + + ++ ++ Sbjct: 377 ARHSVAWDAQTPAAVAALLEDVHAQMYARAKETMETHRVRVTEWTEFVPTLNRKCLILAP 436 Query: 157 Y 157 + Sbjct: 437 W 437 >5W21-A nrPDB Length = 981 Score = 29.9 bits (65), Expect = 1.8, Method: Composition-based stats. Identities = 12/69 (17%), Positives = 24/69 (34%), Gaps = 15/69 (21%) Query: 29 YDQQKYDIFEKLIEKQLSFFWRPEEVDVSRDRI----DY---------QALPEHEKHIFI 75 + Q+ ++ E+++E + W E + S D D+ E EK + Sbjct: 741 FSQKDKEVAERVLEFDIG--WLAEPIFGSGDYPWVMRDWLNQRNNFLLPYFTEDEKKLIQ 798 Query: 76 SNLKYQTLL 84 + L Sbjct: 799 GTFDFLALS 807 >4NMN-A nrPDB Length = 434 Score = 28.7 bits (62), Expect = 4.0, Method: Composition-based stats. Identities = 6/52 (11%), Positives = 20/52 (38%) Query: 280 AAQQEKDWADYLFRDGSMIGLNKDILCQYVEYITNIRMQAVGLDLPFQTRSN 331 + DW + L+ + +++ + + +G++L + + N Sbjct: 72 LQKIPIDWLEELYEEAVSPDTLEEVCKIVKQRSAQRAIIQLGIELIHKGKEN 123 >4XFE-A nrPDB Length = 341 Score = 28.3 bits (61), Expect = 5.8, Method: Composition-based stats. Identities = 5/28 (17%), Positives = 11/28 (39%), Gaps = 2/28 (7%) Query: 50 RPEEVDVSRDRIDYQALPEHEKHIFISN 77 PE V +S+ + L ++ + Sbjct: 234 LPEPVVMSK--TTWNKLTPEQQVLVKKV 259 >3DFA-A nrPDB Length = 286 Score = 27.9 bits (60), Expect = 8.2, Method: Composition-based stats. Identities = 3/22 (13%), Positives = 9/22 (40%) Query: 59 DRIDYQALPEHEKHIFISNLKY 80 D ++ + + K + L + Sbjct: 242 DLPQWRTISDDAKDLIRKMLTF 263 >4YZB-A nrPDB Length = 491 Score = 27.5 bits (59), Expect = 8.5, Method: Composition-based stats. Identities = 24/167 (14%), Positives = 54/167 (32%), Gaps = 17/167 (10%) Query: 59 DRIDYQALPEHEKHIFISNLKY-----QTLLDSIQGRSP--NVALLPLISIPELETWVET 111 D ++ + E K + L Y + D+++ A I +P LE+ + Sbjct: 251 DLPQWKKVSEPAKDLIRKMLAYVPTMRISARDALEHEWLKTTDAATDSIDVPSLESTILN 310 Query: 112 W-AFS--ETIHSRSYTHIIRNIVNDPSVVFDDIVTNEQIQKRAEGISSYYDELIEMTSYW 168 F + + + + ++ + + + N+ Q+ + D+ M Y Sbjct: 311 IRQFQGTQKLAAAALLYMGSKLTTNEET----VELNKIFQRMDKNGDGQLDKQELMEGYV 366 Query: 169 HLLGEGTHTVNGKTVTVSLRELKKKLYLCLMSVNALEAIRFYVSFAC 215 L+ V+ + E+++ L N Y F Sbjct: 367 ELMKLKGEDVSALDQSAIEFEVEQVLDAVDFDKN---GFIEYSEFVT 410 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.308 0.116 0.287 Lambda K H 0.267 0.0355 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 12,460,144 Number of Sequences: 36641 Number of extensions: 452264 Number of successful extensions: 1556 Number of sequences better than 10.0: 39 Number of HSP's better than 10.0 without gapping: 62 Number of HSP's successfully gapped in prelim test: 16 Number of HSP's that attempted gapping in prelim test: 1343 Number of HSP's gapped (non-prelim): 101 length of query: 376 length of database: 10,336,785 effective HSP length: 99 effective length of query: 277 effective length of database: 6,709,326 effective search space: 1858483302 effective search space used: 1858483302 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.4 bits) S2: 59 (27.5 bits)