BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P68404 (671 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 3PFQ-A nrPDB 1341 0.0 2I0E-A nrPDB 669 0.0 4RA4-A nrPDB 594 e-170 3TXO-A nrPDB 411 e-115 5F9E-A nrPDB 395 e-110 3A8W-A nrPDB 369 e-102 2JDO-A nrPDB 331 7e-91 3MV5-A nrPDB 320 9e-88 5KCV-A nrPDB 317 2e-86 4CRS-A nrPDB 301 5e-82 3HDN-A nrPDB 300 2e-81 4OTD-A nrPDB 299 3e-81 1A25-A nrPDB 278 4e-75 4L42-A nrPDB 267 9e-72 5D9K-A nrPDB 266 2e-71 2Z7Q-A nrPDB 261 5e-70 1VZO-A nrPDB 253 2e-67 4RLP-A nrPDB 248 7e-66 1FOT-A nrPDB 246 3e-65 5X3F-B nrPDB 243 1e-64 5N23-A nrPDB 243 2e-64 4WB7-A nrPDB 241 5e-64 4DNL-A nrPDB 231 7e-61 5LOH-A nrPDB 223 3e-58 6BDL-A nrPDB 206 2e-53 2UZP-A nrPDB 206 4e-53 4TNB-A nrPDB 203 2e-52 3NYO-A nrPDB 201 1e-51 6E9W-A nrPDB 199 4e-51 4YHJ-A nrPDB 199 4e-51 3C51-A nrPDB 197 1e-50 6ED6-A nrPDB 197 1e-50 4AW2-A nrPDB 193 2e-49 5FET-A nrPDB 192 3e-49 3TKU-A nrPDB 191 1e-48 5UUU-A nrPDB 189 5e-48 3PVW-A nrPDB 188 6e-48 3ORZ-A nrPDB 186 4e-47 5DYK-A nrPDB 183 2e-46 2VD5-A nrPDB 180 2e-45 6BXI-A nrPDB 167 1e-41 4FR4-A nrPDB 163 2e-40 4C0T-A nrPDB 162 4e-40 2JC6-A nrPDB 149 4e-36 2ELI-A nrPDB 145 4e-35 4FG9-A nrPDB 143 2e-34 5ES1-A nrPDB 141 7e-34 4REW-A nrPDB 141 9e-34 4CFH-A nrPDB 141 9e-34 5KZ7-A nrPDB 141 1e-33 1TBN-A nrPDB 140 2e-33 4RED-A nrPDB 139 3e-33 5EZV-A nrPDB 139 4e-33 4CFF-A nrPDB 139 5e-33 2QNJ-A nrPDB 138 9e-33 3D2K-A nrPDB 137 1e-32 4CZT-A nrPDB 137 1e-32 4UZD-A nrPDB 136 3e-32 2JAM-A nrPDB 135 4e-32 2E73-A nrPDB 135 7e-32 4B8L-A nrPDB 134 1e-31 2YZA-A nrPDB 134 2e-31 4D28-A nrPDB 131 1e-30 3UC3-A nrPDB 131 1e-30 2HAK-A nrPDB 130 3e-30 4JXF-A nrPDB 129 3e-30 4LQP-A nrPDB 129 3e-30 3MN3-A nrPDB 129 4e-30 3LM0-A nrPDB 129 4e-30 6C9D-A nrPDB 129 4e-30 4AF3-A nrPDB 128 8e-30 2OU7-A nrPDB 127 2e-29 4J52-A nrPDB 126 3e-29 3KN6-A nrPDB 126 4e-29 3UDB-A nrPDB 125 4e-29 4I6B-A nrPDB 125 8e-29 5WAX-A nrPDB 122 4e-28 3DB8-A nrPDB 121 9e-28 3ZUT-A nrPDB 121 1e-27 4B6L-A nrPDB 120 2e-27 4YNZ-A nrPDB 120 3e-27 2W4O-A nrPDB 119 3e-27 2YAB-A nrPDB 119 4e-27 5FG8-A nrPDB 119 4e-27 2J90-A nrPDB 119 6e-27 5XZW-A nrPDB 118 8e-27 2VN9-A nrPDB 118 9e-27 2V7O-A nrPDB 118 9e-27 3H4J-B nrPDB 118 1e-26 2BDW-A nrPDB 117 1e-26 4MVF-A nrPDB 117 2e-26 3KK8-A nrPDB 116 2e-26 5U6Y-A nrPDB 116 3e-26 2VZ6-A nrPDB 115 6e-26 2A27-A nrPDB 115 9e-26 5JN2-A nrPDB 115 9e-26 4CQG-A nrPDB 114 1e-25 3MA6-A nrPDB 114 1e-25 1ZWS-A nrPDB 114 1e-25 3NCG-A nrPDB 113 2e-25 3HZT-A nrPDB 113 2e-25 3DFA-A nrPDB 113 2e-25 4PDS-A nrPDB 113 3e-25 3DXN-A nrPDB 113 3e-25 3SOA-A nrPDB 112 4e-25 5IG1-A nrPDB 112 4e-25 3BHH-A nrPDB 112 6e-25 5JZN-A nrPDB 112 6e-25 4D2V-A nrPDB 112 7e-25 4YZB-A nrPDB 111 8e-25 4WNO-A nrPDB 111 1e-24 4RGJ-A nrPDB 111 1e-24 4FIE-A nrPDB 109 4e-24 2F57-A nrPDB 109 4e-24 6FDY-U nrPDB 109 5e-24 3GUB-A nrPDB 108 8e-24 4JDH-A nrPDB 107 1e-23 5J5T-A nrPDB 107 1e-23 4XBR-A nrPDB 107 2e-23 2Q0N-A nrPDB 107 2e-23 1KOB-A nrPDB 105 9e-23 6CMJ-A nrPDB 104 1e-22 6E2O-A nrPDB 103 2e-22 4NIF-A nrPDB 103 2e-22 5YKS-A nrPDB 103 2e-22 2HW6-A nrPDB 103 2e-22 3LIJ-A nrPDB 103 3e-22 6QAU-A nrPDB 102 4e-22 2XIK-A nrPDB 102 5e-22 4QMW-A nrPDB 102 6e-22 4KS7-A nrPDB 102 7e-22 6HXF-B nrPDB 102 8e-22 6FD3-A nrPDB 100 2e-21 3Q53-A nrPDB 100 2e-21 2Y7J-A nrPDB 99 5e-21 1KOA-A nrPDB 99 6e-21 4FZF-B nrPDB 99 6e-21 4APC-A nrPDB 99 7e-21 3PPZ-A nrPDB 99 7e-21 3UTO-A nrPDB 99 8e-21 3Q5I-A nrPDB 98 9e-21 3F3Z-A nrPDB 98 1e-20 2YCR-A nrPDB 97 2e-20 5YV8-A nrPDB 97 2e-20 4JG6-A nrPDB 97 3e-20 2BRG-A nrPDB 97 3e-20 3I6U-A nrPDB 96 4e-20 3TAC-A nrPDB 95 9e-20 4CSV-A nrPDB 95 1e-19 4UYA-A nrPDB 95 1e-19 4XEY-B nrPDB 95 1e-19 3DLS-A nrPDB 95 1e-19 6CKI-A nrPDB 94 2e-19 2FO0-A nrPDB 94 2e-19 4UY9-A nrPDB 93 3e-19 1PHK-A nrPDB 93 4e-19 6NPU-A nrPDB 93 4e-19 6CCF-A nrPDB 93 4e-19 6CQF-A nrPDB 93 5e-19 4Y93-A nrPDB 92 5e-19 2UV2-A nrPDB 92 7e-19 2X4F-A nrPDB 92 7e-19 2XYN-A nrPDB 92 9e-19 5A46-A nrPDB 91 1e-18 3DTC-A nrPDB 91 1e-18 3TT0-A nrPDB 91 1e-18 5VO2-A nrPDB 91 2e-18 5L2Q-C nrPDB 91 2e-18 3GQL-A nrPDB 91 2e-18 2ENN-A nrPDB 90 2e-18 4BGQ-A nrPDB 90 3e-18 2OZA-A nrPDB 90 3e-18 1NY3-A nrPDB 90 3e-18 4KIK-B nrPDB 89 4e-18 3KA0-A nrPDB 89 6e-18 3COM-A nrPDB 89 6e-18 2XNP-A nrPDB 89 6e-18 3SXS-A nrPDB 89 7e-18 2PSQ-A nrPDB 89 9e-18 4LDC-A nrPDB 89 9e-18 3IS5-A nrPDB 88 1e-17 5TQX-A nrPDB 88 1e-17 3FXW-A nrPDB 88 1e-17 1TKI-A nrPDB 88 1e-17 4E93-A nrPDB 88 1e-17 2WTK-C nrPDB 88 2e-17 2BPM-A nrPDB 87 2e-17 4XI2-A nrPDB 87 2e-17 6E4F-A nrPDB 87 2e-17 4X3F-A nrPDB 87 2e-17 4K33-A nrPDB 87 2e-17 5X5O-A nrPDB 87 3e-17 5EG3-A nrPDB 86 3e-17 1RH8-A nrPDB 86 4e-17 4OW8-A nrPDB 86 5e-17 2ENZ-A nrPDB 86 5e-17 6AO5-A nrPDB 85 9e-17 4XCU-A nrPDB 85 1e-16 4X7Q-B nrPDB 85 1e-16 5LOB-A nrPDB 85 1e-16 4LG4-A nrPDB 85 1e-16 6B2Q-A nrPDB 84 1e-16 3QGY-A nrPDB 84 1e-16 5HI2-A nrPDB 84 2e-16 5KKR-C nrPDB 84 2e-16 2CM5-A nrPDB 84 2e-16 3DAK-A nrPDB 84 3e-16 4FKD-A nrPDB 84 3e-16 2DQ7-X nrPDB 84 3e-16 3EQC-A nrPDB 83 3e-16 4IDT-A nrPDB 83 3e-16 3OZ6-A nrPDB 83 3e-16 5G6V-A nrPDB 83 5e-16 4EQM-A nrPDB 82 6e-16 3RPB-A nrPDB 82 6e-16 3QA8-A nrPDB 82 7e-16 3ORP-A nrPDB 82 7e-16 5DBX-A nrPDB 82 9e-16 2YUU-A nrPDB 82 9e-16 5HIE-A nrPDB 82 1e-15 4G3E-A nrPDB 82 1e-15 1S9I-A nrPDB 82 1e-15 6GU6-A nrPDB 80 3e-15 3OMV-A nrPDB 80 3e-15 2H8H-A nrPDB 80 3e-15 1K9A-A nrPDB 80 3e-15 4AN9-A nrPDB 80 3e-15 6F3F-A nrPDB 80 4e-15 4YFF-A nrPDB 79 4e-15 4BBM-A nrPDB 79 4e-15 4HVI-A nrPDB 79 4e-15 5D7A-A nrPDB 79 5e-15 3HKO-A nrPDB 79 5e-15 1BYG-A nrPDB 79 6e-15 4NEU-A nrPDB 79 7e-15 5HVK-A nrPDB 79 8e-15 2WQN-A nrPDB 79 9e-15 3A4O-X nrPDB 78 1e-14 3CJF-A nrPDB 78 1e-14 5UE8-A nrPDB 78 1e-14 3C1X-A nrPDB 78 2e-14 5TOS-A nrPDB 78 2e-14 2HK5-A nrPDB 77 2e-14 3BEA-A nrPDB 77 2e-14 2CHD-A nrPDB 77 2e-14 5TUR-A nrPDB 77 2e-14 1AD5-A nrPDB 77 2e-14 4U41-A nrPDB 77 3e-14 5O2C-A nrPDB 77 3e-14 5SYS-A nrPDB 77 4e-14 5B2L-A nrPDB 76 4e-14 2PL0-A nrPDB 76 4e-14 4RC3-A nrPDB 76 5e-14 5U6B-A nrPDB 76 5e-14 4KRC-A nrPDB 76 6e-14 3BGP-A nrPDB 75 6e-14 4TPT-A nrPDB 75 6e-14 5O2B-A nrPDB 75 7e-14 4FL3-A nrPDB 75 8e-14 1FVR-A nrPDB 75 8e-14 6GQK-A nrPDB 75 1e-13 2A1A-B nrPDB 75 1e-13 3UEY-A nrPDB 75 1e-13 3E3P-A nrPDB 75 1e-13 3GC9-A nrPDB 75 1e-13 3QUP-A nrPDB 74 2e-13 5H2U-A nrPDB 74 2e-13 5C26-A nrPDB 74 2e-13 4LCV-A nrPDB 74 2e-13 4AU8-A nrPDB 74 3e-13 2OGV-A nrPDB 74 3e-13 5HLW-A nrPDB 74 3e-13 1U59-A nrPDB 74 3e-13 5AIR-A nrPDB 73 3e-13 4QNY-A nrPDB 73 4e-13 3UIU-A nrPDB 73 4e-13 4HZS-A nrPDB 73 4e-13 6DC0-A nrPDB 73 4e-13 5CEK-A nrPDB 73 4e-13 1U54-B nrPDB 73 5e-13 3OHT-A nrPDB 73 5e-13 2OZO-A nrPDB 72 5e-13 5WNO-A nrPDB 72 6e-13 5U6C-A nrPDB 72 7e-13 2GCD-A nrPDB 72 7e-13 1U5R-A nrPDB 72 8e-13 4OLI-A nrPDB 72 8e-13 2W1I-A nrPDB 72 9e-13 3V5Q-A nrPDB 72 9e-13 3IO7-A nrPDB 72 9e-13 3KRL-A nrPDB 72 1e-12 4XUF-A nrPDB 71 1e-12 4GS6-A nrPDB 71 2e-12 1CM8-A nrPDB 71 2e-12 6DBM-A nrPDB 71 2e-12 4R7H-A nrPDB 71 2e-12 5X02-A nrPDB 71 2e-12 3ZDU-A nrPDB 70 2e-12 2H34-A nrPDB 70 2e-12 4NST-A nrPDB 70 3e-12 2I6L-A nrPDB 70 4e-12 6J5U-C nrPDB 70 4e-12 6FEX-A nrPDB 70 4e-12 5Y86-A nrPDB 70 4e-12 3KUL-B nrPDB 69 5e-12 2WO6-A nrPDB 69 5e-12 4PWN-A nrPDB 69 5e-12 4EWQ-A nrPDB 69 5e-12 6DTL-A nrPDB 69 5e-12 5ZTN-A nrPDB 69 5e-12 6CTH-A nrPDB 69 6e-12 6BSD-A nrPDB 69 7e-12 5Z33-A nrPDB 69 7e-12 5GRN-A nrPDB 69 7e-12 4Y83-A nrPDB 69 7e-12 1UA2-A nrPDB 69 9e-12 4F0G-A nrPDB 69 9e-12 4QTB-A nrPDB 68 1e-11 2J0K-A nrPDB 68 1e-11 3N9X-A nrPDB 68 1e-11 4AT3-A nrPDB 68 1e-11 3PP0-A nrPDB 68 1e-11 4MJJ-A nrPDB 67 2e-11 2XS0-A nrPDB 67 2e-11 3E7O-A nrPDB 67 2e-11 3VHK-A nrPDB 67 2e-11 4PDO-A nrPDB 67 3e-11 6FER-A nrPDB 67 3e-11 2PMN-X nrPDB 67 3e-11 5AWM-A nrPDB 67 3e-11 1XA6-A nrPDB 67 3e-11 5EFQ-A nrPDB 67 3e-11 4IC8-A nrPDB 67 4e-11 1DQV-A nrPDB 67 4e-11 1G3N-A nrPDB 66 4e-11 5NGU-A nrPDB 66 4e-11 1LUF-A nrPDB 66 4e-11 4MYG-A nrPDB 66 4e-11 1V0B-A nrPDB 66 5e-11 4EBW-A nrPDB 66 5e-11 4JLC-A nrPDB 66 5e-11 5GNK-A nrPDB 66 6e-11 1ZXE-A nrPDB 66 6e-11 3CXL-A nrPDB 66 6e-11 3ALO-A nrPDB 66 6e-11 5O0Y-A nrPDB 66 6e-11 3DKO-A nrPDB 66 6e-11 4LRM-A nrPDB 65 7e-11 4ZSG-A nrPDB 65 7e-11 3NIE-A nrPDB 65 8e-11 4H1J-A nrPDB 65 8e-11 3HNG-A nrPDB 65 1e-10 3BBT-B nrPDB 65 1e-10 3G0E-A nrPDB 65 1e-10 2Y6O-A nrPDB 65 1e-10 6ANJ-A nrPDB 65 1e-10 3LMG-A nrPDB 65 1e-10 5AMN-A nrPDB 65 1e-10 3NIZ-A nrPDB 64 1e-10 2D8K-A nrPDB 64 1e-10 5KMM-A nrPDB 64 2e-10 4AGU-A nrPDB 64 2e-10 6DBN-A nrPDB 64 2e-10 3M42-A nrPDB 64 2e-10 3FI2-A nrPDB 64 2e-10 4IAN-A nrPDB 64 2e-10 1JNK-A nrPDB 64 2e-10 3LZB-A nrPDB 64 2e-10 3UIM-A nrPDB 64 2e-10 4E7W-A nrPDB 64 3e-10 5VD3-A nrPDB 64 3e-10 6ANK-A nrPDB 63 4e-10 4XLV-A nrPDB 62 6e-10 6NT9-A nrPDB 62 6e-10 3PG1-A nrPDB 62 6e-10 4P5Q-A nrPDB 62 7e-10 4EUU-A nrPDB 62 7e-10 4EUT-A nrPDB 62 7e-10 4E20-A nrPDB 62 8e-10 2R2P-A nrPDB 62 8e-10 5AR8-A nrPDB 62 9e-10 1JPA-A nrPDB 62 9e-10 1UOW-A nrPDB 62 9e-10 2VWV-A nrPDB 62 1e-09 5LPV-A nrPDB 62 1e-09 5LPZ-A nrPDB 62 1e-09 4M7I-A nrPDB 62 1e-09 3ZBF-A nrPDB 61 1e-09 4L9M-A nrPDB 61 1e-09 6O8B-A nrPDB 61 1e-09 2F9G-A nrPDB 61 1e-09 5W5C-F nrPDB 61 2e-09 2W96-B nrPDB 61 2e-09 5MJB-A nrPDB 61 2e-09 2BUJ-A nrPDB 61 2e-09 5FM2-A nrPDB 60 2e-09 3VN9-A nrPDB 60 3e-09 3AOX-A nrPDB 60 4e-09 3PLS-A nrPDB 60 4e-09 1W15-A nrPDB 60 4e-09 4C59-A nrPDB 60 4e-09 5UIU-A nrPDB 59 5e-09 2BWQ-A nrPDB 59 6e-09 4M66-A nrPDB 59 6e-09 5H4Y-A nrPDB 59 7e-09 5OAT-A nrPDB 59 8e-09 4O2Z-A nrPDB 59 9e-09 3LLT-A nrPDB 59 9e-09 3ZZW-A nrPDB 59 1e-08 4TS6-A nrPDB 58 1e-08 2QKW-B nrPDB 58 1e-08 5L6P-A nrPDB 58 1e-08 3GC0-A nrPDB 57 2e-08 6HMD-A nrPDB 57 2e-08 3I81-A nrPDB 57 2e-08 2PZI-A nrPDB 57 3e-08 2DMG-A nrPDB 57 3e-08 2KI6-A nrPDB 57 3e-08 3FME-A nrPDB 57 4e-08 6EII-A nrPDB 56 4e-08 1RSY-A nrPDB 56 4e-08 3F01-A nrPDB 56 5e-08 4MD7-E nrPDB 56 5e-08 4Y12-A nrPDB 55 7e-08 5M07-A nrPDB 55 9e-08 3RP9-A nrPDB 55 1e-07 3Q4U-A nrPDB 55 1e-07 1UGK-A nrPDB 54 2e-07 4RT7-A nrPDB 54 2e-07 3EB0-A nrPDB 54 2e-07 3FDW-A nrPDB 54 2e-07 6NYT-A nrPDB 54 2e-07 5XD6-A nrPDB 54 3e-07 6O6Q-A nrPDB 54 3e-07 3HMP-A nrPDB 54 3e-07 2JD5-A nrPDB 53 5e-07 5WNL-A nrPDB 53 5e-07 2RIO-A nrPDB 53 5e-07 5IKW-A nrPDB 53 5e-07 5XVU-A nrPDB 52 6e-07 3QD2-B nrPDB 52 6e-07 4LFI-A nrPDB 52 1e-06 5X8I-B nrPDB 52 1e-06 5IXC-A nrPDB 51 2e-06 2ZMD-A nrPDB 51 2e-06 6BFN-A nrPDB 50 2e-06 1Y8F-A nrPDB 50 2e-06 6GVJ-A nrPDB 50 2e-06 3N5A-A nrPDB 50 2e-06 5A50-A nrPDB 50 3e-06 3REP-A nrPDB 50 3e-06 3MIA-A nrPDB 50 4e-06 5TE0-A nrPDB 49 5e-06 6EQI-C nrPDB 49 7e-06 2Y4I-B nrPDB 49 8e-06 3MY0-A nrPDB 48 1e-05 2PVN-A nrPDB 48 1e-05 5AP3-A nrPDB 48 1e-05 4CRL-A nrPDB 48 2e-05 5A52-A nrPDB 47 2e-05 4M69-B nrPDB 47 2e-05 3RAW-A nrPDB 47 3e-05 5VC6-A nrPDB 47 4e-05 6FYV-A nrPDB 47 4e-05 4BTF-A nrPDB 46 4e-05 3JZY-A nrPDB 46 4e-05 5UNP-A nrPDB 46 5e-05 2CMW-A nrPDB 45 1e-04 3KY9-A nrPDB 45 1e-04 4PL5-B nrPDB 44 2e-04 4F9B-A nrPDB 44 2e-04 3BJI-A nrPDB 44 2e-04 6HV0-A nrPDB 44 2e-04 5VDK-A nrPDB 44 3e-04 2VRW-B nrPDB 43 6e-04 3MDY-A nrPDB 42 7e-04 1BCI-A nrPDB 42 7e-04 2C47-A nrPDB 42 7e-04 1RLW-A nrPDB 42 7e-04 2Q3X-A nrPDB 42 8e-04 4NPK-A nrPDB 42 0.001 2CHL-A nrPDB 42 0.001 4P42-A nrPDB 42 0.001 5YQ3-A nrPDB 42 0.001 1CJY-A nrPDB 42 0.001 4RJ9-A nrPDB 41 0.002 4NT4-A nrPDB 41 0.002 4JRN-A nrPDB 41 0.002 2DB6-A nrPDB 40 0.003 4I94-A nrPDB 40 0.003 5CLR-A nrPDB 40 0.004 3G2F-A nrPDB 39 0.010 5X1R-A nrPDB 38 0.011 1PY5-A nrPDB 38 0.017 3SV0-A nrPDB 37 0.019 5X18-A nrPDB 37 0.037 6G4J-A nrPDB 36 0.067 6G18-v nrPDB 35 0.12 1CSN-A nrPDB 35 0.15 3SOC-A nrPDB 35 0.15 >3PFQ-A nrPDB Length = 674 Score = 1341 bits (3471), Expect = 0.0, Method: Compositional matrix adjust. Identities = 643/668 (96%), Positives = 650/668 (97%), Gaps = 1/668 (0%) Query: 1 MADPAAGPPPSEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGF 60 MADPAAGPPPSEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGF Sbjct: 2 MADPAAGPPPSEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGF 61 Query: 61 GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGS 120 GKQGFQCQVC FVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGS Sbjct: 62 GKQGFQCQVCSFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGS 121 Query: 121 LLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDREVLIVVVRDA 180 LLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDREVLIVVVRDA Sbjct: 122 LLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDREVLIVVVRDA 181 Query: 181 KNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRL 240 KNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIK SLNPEWNETFRFQLKESDKDRRL Sbjct: 182 KNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKSSLNPEWNETFRFQLKESDKDRRL 241 Query: 241 SVEIWDWDLTSRNDFMGSLSFGISELQKAGVDGWFKLLSQEEGEYFNVPVPPEGSEGNEE 300 SVEIWDWDLTSRNDFMGSLSFGISELQKAGVDGWFKLLSQEEGEYFNVPVPPEGSEGNEE Sbjct: 242 SVEIWDWDLTSRNDFMGSLSFGISELQKAGVDGWFKLLSQEEGEYFNVPVPPEGSEGNEE 301 Query: 301 LRQKFERAKIGQGTKAPEEKTANTISKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSE 360 LRQKFERAKIGQGTKAPEEKTANTISKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSE Sbjct: 302 LRQKFERAKIGQGTKAPEEKTANTISKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSE 361 Query: 361 RKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVM 420 RKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVM Sbjct: 362 RKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVM 421 Query: 421 EYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHI 480 EYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHI Sbjct: 422 EYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHI 481 Query: 481 KIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAP 540 KIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAP Sbjct: 482 KIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAP 541 Query: 541 FEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFF 600 FEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFF Sbjct: 542 FEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFF 601 Query: 601 RYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEFTRQPVELTPTDKLFIMNLDQNEFAGF 660 RYIDWEKLERKEIQPPYKPKA R+ NFD+ FTR P LTP D+ I N+DQ+EF GF Sbjct: 602 RYIDWEKLERKEIQPPYKPKA-SGRNAENFDRFFTRHPPVLTPPDQEVIRNIDQSEFEGF 660 Query: 661 SYTNPEFV 668 S+ N EF+ Sbjct: 661 SFVNSEFL 668 >2I0E-A nrPDB Length = 353 Score = 669 bits (1727), Expect = 0.0, Method: Compositional matrix adjust. Identities = 323/348 (92%), Positives = 331/348 (95%), Gaps = 1/348 (0%) Query: 321 TANTISKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQ 380 T NT+SKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQ Sbjct: 1 TTNTVSKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQ 60 Query: 381 DDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKE 440 DDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKE Sbjct: 61 DDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKE 120 Query: 441 PHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKT 500 PHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKT Sbjct: 121 PHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKT 180 Query: 501 FCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAY 560 FCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAY Sbjct: 181 FCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAY 240 Query: 561 PKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPK 620 PKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPK Sbjct: 241 PKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPK 300 Query: 621 ARDKRDTSNFDKEFTRQPVELTPTDKLFIMNLDQNEFAGFSYTNPEFV 668 A R+ NFD+ FTR P LTP D+ I N+DQ+EF GFS+ N EF+ Sbjct: 301 ACG-RNAENFDRFFTRHPPVLTPPDQEVIRNIDQSEFEGFSFVNSEFL 347 >4RA4-A nrPDB Length = 355 Score = 594 bits (1532), Expect = e-170, Method: Compositional matrix adjust. Identities = 285/339 (84%), Positives = 312/339 (92%), Gaps = 3/339 (0%) Query: 331 NGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVE 390 + N DR+KLTDFNFLMVLGKGSFGKVML++RKGT+ELYA+KILKKDVVIQDDDVECTMVE Sbjct: 11 SNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVE 70 Query: 391 KRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEI 450 KRVLAL KPPFLTQLHSCFQT+DRLYFVMEYVNGGDLMYHIQQVG+FKEP AVFYAAEI Sbjct: 71 KRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEI 130 Query: 451 AIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAP 510 +IGLFFL +GIIYRDLKLDNVMLDSEGHIKIADFGMCKE++ DGVTT+TFCGTPDYIAP Sbjct: 131 SIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAP 190 Query: 511 EIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVA 570 EIIAYQPYGKSVDWWA+GVLLYEMLAGQ PF+GEDEDELFQSIMEHNV+YPKS+SKEAV+ Sbjct: 191 EIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVS 250 Query: 571 ICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNF 630 ICKGLMTKHP KRLGCGPEGERD++EHAFFR IDWEKLE +EIQPP+KPK K NF Sbjct: 251 ICKGLMTKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVSGK-GAENF 309 Query: 631 DKEFTR-QPVELTPTDKLFIMNLDQNEFAGFSYTNPEFV 668 DK FTR QPV LTP D+L I N+DQ++F GFSY NP+FV Sbjct: 310 DKFFTRGQPV-LTPPDQLVIANIDQSDFEGFSYVNPQFV 347 >3TXO-A nrPDB Length = 353 Score = 411 bits (1056), Expect = e-115, Method: Compositional matrix adjust. Identities = 196/336 (58%), Positives = 247/336 (73%), Gaps = 1/336 (0%) Query: 333 NRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKR 392 + +R+ + +F F+ VLGKGSFGKVML+ K T +LYAVK+LKKDV++QDDDVECTM EKR Sbjct: 16 SSNRLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKR 75 Query: 393 VLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAI 452 +L+L PFLTQL CFQT DRL+FVME+VNGGDLM+HIQ+ RF E A FYAAEI Sbjct: 76 ILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIIS 135 Query: 453 GLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEI 512 L FL KGIIYRDLKLDNV+LD EGH K+ADFGMCKE I +GVTT TFCGTPDYIAPEI Sbjct: 136 ALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEI 195 Query: 513 IAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAIC 572 + YG +VDWWA GVLLYEML G APFE E+ED+LF++I+ V YP + ++A I Sbjct: 196 LQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGIL 255 Query: 573 KGLMTKHPGKRLGCGPE-GERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFD 631 K MTK+P RLG + GE I H FF+ IDW +L ++I+PP++P+ + + D SNFD Sbjct: 256 KSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFD 315 Query: 632 KEFTRQPVELTPTDKLFIMNLDQNEFAGFSYTNPEF 667 +F ++ LTP D+ + ++Q+EF F Y +PE Sbjct: 316 PDFIKEEPVLTPIDEGHLPMINQDEFRNFEYVSPEL 351 >5F9E-A nrPDB Length = 353 Score = 395 bits (1014), Expect = e-110, Method: Compositional matrix adjust. Identities = 192/330 (58%), Positives = 237/330 (71%), Gaps = 4/330 (1%) Query: 336 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 395 ++K+ DF +LGKGSFGKV L+E K T++ +A+K LKKDVV+ DDDVECTMVEKRVL+ Sbjct: 15 KLKIEDFELHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLS 74 Query: 396 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 455 L + PFLT + FQT + L+FVMEY+NGGDLMYHIQ +F A FYAAEI +GL Sbjct: 75 LAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQ 134 Query: 456 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAY 515 FL SKGI+YRDLKLDN++LD +GHIKIADFGMCKEN+ T FCGTPDYIAPEI+ Sbjct: 135 FLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNEFCGTPDYIAPEILLG 194 Query: 516 QPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGL 575 Q Y SVDWW+FGVLLYEML GQ+PF G+DE+ELF SI N YP+ + KEA + L Sbjct: 195 QKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEKEAKDLLVKL 254 Query: 576 MTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEFT 635 + P KRLG DI++H FR I+WE+LERKEI PP++PK + D SNFDKEF Sbjct: 255 FVREPEKRLGV----RGDIRQHPLFREINWEELERKEIDPPFRPKVKSPFDCSNFDKEFL 310 Query: 636 RQPVELTPTDKLFIMNLDQNEFAGFSYTNP 665 + L+ D+ I ++DQN F FS+ NP Sbjct: 311 NEKPRLSFADRALINSMDQNMFRNFSFMNP 340 >3A8W-A nrPDB Length = 345 Score = 369 bits (948), Expect = e-102, Method: Compositional matrix adjust. Identities = 174/344 (50%), Positives = 238/344 (69%), Gaps = 10/344 (2%) Query: 332 GNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEK 391 G D + L DF+ L V+G+GS+ KV+L K TD +YA+K++KK++V D+D++ EK Sbjct: 1 GAMDPLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEK 60 Query: 392 RVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIA 451 V PFL LHSCFQT RL+FV+EYVNGGDLM+H+Q+ + E HA FY+AEI+ Sbjct: 61 HVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEIS 120 Query: 452 IGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPE 511 + L +L +GIIYRDLKLDNV+LDSEGHIK+ D+GMCKE + G TT TFCGTP+YIAPE Sbjct: 121 LALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPE 180 Query: 512 IIAYQPYGKSVDWWAFGVLLYEMLAGQAPF---------EGEDEDELFQSIMEHNVAYPK 562 I+ + YG SVDWWA GVL++EM+AG++PF + ED LFQ I+E + P+ Sbjct: 181 ILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPR 240 Query: 563 SMSKEAVAICKGLMTKHPGKRLGCGPE-GERDIKEHAFFRYIDWEKLERKEIQPPYKPKA 621 S+S +A ++ K + K P +RLGC P+ G DI+ H FFR +DW+ +E+K++ PP+KP Sbjct: 241 SLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNI 300 Query: 622 RDKRDTSNFDKEFTRQPVELTPTDKLFIMNLDQNEFAGFSYTNP 665 + NFD +FT +PV+LTP D + +DQ+EF GF Y NP Sbjct: 301 SGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINP 344 >2JDO-A nrPDB Length = 342 Score = 331 bits (848), Expect = 7e-91, Method: Compositional matrix adjust. Identities = 157/334 (47%), Positives = 225/334 (67%), Gaps = 8/334 (2%) Query: 336 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 395 ++ + DF++L +LGKG+FGKV+L K T YA+KIL+K+V+I D+V T+ E RVL Sbjct: 6 KVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQ 65 Query: 396 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 455 + PFLT L FQT DRL FVMEY NGG+L +H+ + F E A FY AEI L Sbjct: 66 -NTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALE 124 Query: 456 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAY 515 +L S+ ++YRD+KL+N+MLD +GHIKI DFG+CKE I DG T KTFCGTP+Y+APE++ Sbjct: 125 YLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLED 184 Query: 516 QPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGL 575 YG++VDWW GV++YEM+ G+ PF +D + LF+ I+ + +P+++S EA ++ GL Sbjct: 185 NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGL 244 Query: 576 MTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEFT 635 + K P +RLG GP +++ EH FF I+W+ + +K++ PP+KP+ + DT FD EFT Sbjct: 245 LKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFT 304 Query: 636 RQPVELTPTDK---LFIMNLDQNE----FAGFSY 662 Q + +TP D+ L ++ LDQ E F F Y Sbjct: 305 AQSITITPPDRYDSLGLLELDQREEQEMFEDFDY 338 >3MV5-A nrPDB Length = 342 Score = 320 bits (821), Expect = 9e-88, Method: Compositional matrix adjust. Identities = 150/312 (48%), Positives = 214/312 (68%), Gaps = 2/312 (0%) Query: 336 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 395 R+ + +F +L +LGKG+FGKV+L + K T YA+KILKK+V++ D+V T+ E RVL Sbjct: 6 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 65 Query: 396 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 455 + PFLT L FQT DRL FVMEY NGG+L +H+ + F E A FY AEI L Sbjct: 66 -NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALD 124 Query: 456 FLQS-KGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA 514 +L S K ++YRDLKL+N+MLD +GHIKI DFG+CKE I DG T KTFCGTP+Y+APE++ Sbjct: 125 YLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLE 184 Query: 515 YQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKG 574 YG++VDWW GV++YEM+ G+ PF +D ++LF+ I+ + +P+++ EA ++ G Sbjct: 185 DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSG 244 Query: 575 LMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEF 634 L+ K P +RLG G E ++I +H FF I W+ + K++ PP+KP+ + DT FD+EF Sbjct: 245 LLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEF 304 Query: 635 TRQPVELTPTDK 646 T Q + +TP D+ Sbjct: 305 TAQMITITPPDQ 316 >5KCV-A nrPDB Length = 460 Score = 317 bits (811), Expect = 2e-86, Method: Compositional matrix adjust. Identities = 160/363 (44%), Positives = 227/363 (62%), Gaps = 16/363 (4%) Query: 286 FNVPVPPEGSEGNEELRQKFERAKIGQGTKAPEEKTANTISKFDNNGNRD---------- 335 F+V P E EE + G +A E + S DN+G + Sbjct: 102 FHVETPEE----REEWTTAIQTVADGLKKQAAAEMDFRSGSPSDNSGAEEMEVSLAKPKH 157 Query: 336 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 395 R+ + +F +L +LGKG+FGKV+L + K T YA+KILKK+V++ D+V T+ E RVL Sbjct: 158 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 217 Query: 396 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 455 + PFLT L FQT DRL FVMEY NGG+L +H+ + F E A FY AEI L Sbjct: 218 -NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALD 276 Query: 456 FLQS-KGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA 514 +L S K ++YRDLKL+N+MLD +GHIKI DFG+CKE I DG T KTFCGTP+Y+APE++ Sbjct: 277 YLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLE 336 Query: 515 YQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKG 574 YG++VDWW GV++YEM+ G+ PF +D ++LF+ I+ + +P+++ EA ++ G Sbjct: 337 DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSG 396 Query: 575 LMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEF 634 L+ K P +RLG G E ++I +H FF I W+ + K++ PP+KP+ + DT FD+EF Sbjct: 397 LLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEF 456 Query: 635 TRQ 637 T Q Sbjct: 457 TAQ 459 >4CRS-A nrPDB Length = 341 Score = 301 bits (772), Expect = 5e-82, Method: Compositional matrix adjust. Identities = 157/333 (47%), Positives = 221/333 (66%), Gaps = 4/333 (1%) Query: 333 NRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKR 392 R + L DF VL +G FGKV+L+E K T+E++A+K LKK ++ D+V+ M EKR Sbjct: 5 QRFQFNLQDFRCCAVLLRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKR 64 Query: 393 VLALPG--KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEI 450 + + PFL L +CFQT + + FVMEY GGDLM HI F EP AVFYAA + Sbjct: 65 IFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIH-TDVFSEPRAVFYAACV 123 Query: 451 AIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAP 510 +GL +L I+YRDLKLDN++LD+EG +KIADFG+CKE + G T TFCGTP+++AP Sbjct: 124 VLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAP 183 Query: 511 EIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVA 570 E++ Y ++VDWW GVL+YEML G++PF G+DE+E+F SI+ V YP+ +S EA++ Sbjct: 184 EVLTETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAIS 243 Query: 571 ICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNF 630 I + L+ ++P +RLG + D+K+H FFR IDW L K+++PP+ P R + D SNF Sbjct: 244 IMRRLLRRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNF 303 Query: 631 DKEFTRQPVELTPTDKLFIMNLDQNE-FAGFSY 662 D EFT + LTP + I++ ++ E F F Y Sbjct: 304 DDEFTSEAPILTPPREPRILSEEEQEMFRDFDY 336 >3HDN-A nrPDB Length = 373 Score = 300 bits (767), Expect = 2e-81, Method: Compositional matrix adjust. Identities = 150/334 (44%), Positives = 209/334 (62%), Gaps = 7/334 (2%) Query: 338 KLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALP 397 K +DF+FL V+GKGSFGKV+L+ K + YAVK+L+K +++ + + M E+ VL Sbjct: 36 KPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKN 95 Query: 398 GKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFL 457 K PFL LH FQT D+LYFV++Y+NGG+L YH+Q+ F EP A FYAAEIA L +L Sbjct: 96 VKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYL 155 Query: 458 QSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQP 517 S I+YRDLK +N++LDS+GHI + DFG+CKENI TT TFCGTP+Y+APE++ QP Sbjct: 156 HSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQP 215 Query: 518 YGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMT 577 Y ++VDWW G +LYEML G PF + E++ +I+ + +++ A + +GL+ Sbjct: 216 YDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQ 275 Query: 578 KHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEFTRQ 637 K KRLG + +IK H FF I+W+ L K+I PP+ P D +FD EFT + Sbjct: 276 KDRTKRLGAK-DDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEE 334 Query: 638 PVE----LTPTDKLFIMNLDQ--NEFAGFSYTNP 665 PV P L ++ + F GFSY P Sbjct: 335 PVPNAIGKAPDSVLVTASVKEAAEAFLGFSYAPP 368 >4OTD-A nrPDB Length = 341 Score = 299 bits (765), Expect = 3e-81, Method: Compositional matrix adjust. Identities = 156/330 (47%), Positives = 215/330 (65%), Gaps = 4/330 (1%) Query: 337 MKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA- 395 + L DF FL VLG+G FGKV+LSE + + EL+A+K LKK ++ D+VE M EKR+LA Sbjct: 9 LTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAA 68 Query: 396 -LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGL 454 PFL L CFQT + + FVMEY GGDLM HI F EP A+FY+A + +GL Sbjct: 69 VTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHS-DVFSEPRAIFYSACVVLGL 127 Query: 455 FFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA 514 FL I+YRDLKLDN++LD+EG++KIADFG+CKE + G T TFCGTP+++APE++ Sbjct: 128 QFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLT 187 Query: 515 YQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKG 574 Y ++VDWW GVLLYEML G++PF G+DE+E+F SI+ V YP+ +S EA+ I + Sbjct: 188 DTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRR 247 Query: 575 LMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEF 634 L+ ++P +RLG D+K+ FFR + WE L + + PP+ P + D SNFD+EF Sbjct: 248 LLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFDEEF 307 Query: 635 TRQPVELT-PTDKLFIMNLDQNEFAGFSYT 663 T + L+ P D + +Q F F + Sbjct: 308 TGEAPTLSPPRDARPLTAAEQAAFLDFDFV 337 >1A25-A nrPDB Length = 149 Score = 278 bits (712), Expect = 4e-75, Method: Compositional matrix adjust. Identities = 134/136 (98%), Positives = 134/136 (98%) Query: 154 DHTERRGRIYIQAHIDREVLIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTK 213 D ERRGRIYIQAHIDREVLIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTK Sbjct: 14 DSMERRGRIYIQAHIDREVLIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTK 73 Query: 214 TIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKAGVDG 273 TIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKAGVDG Sbjct: 74 TIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKAGVDG 133 Query: 274 WFKLLSQEEGEYFNVP 289 WFKLLSQEEGEYFNVP Sbjct: 134 WFKLLSQEEGEYFNVP 149 >4L42-A nrPDB Length = 346 Score = 267 bits (683), Expect = 9e-72, Method: Compositional matrix adjust. Identities = 133/343 (38%), Positives = 211/343 (61%), Gaps = 6/343 (1%) Query: 324 TISKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSER---KGTDELYAVKILKKDVVIQ 380 +S+ N ++++ F L VLGKG +GKV + T +++A+K+LKK ++++ Sbjct: 2 AMSETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVR 61 Query: 381 D-DDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFK 439 + D T E+ +L K PF+ L FQT +LY ++EY++GG+L +++ G F Sbjct: 62 NAKDTAHTKAERNILE-EVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFM 120 Query: 440 EPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTK 499 E A FY AEI++ L L KGIIYRDLK +N+ML+ +GH+K+ DFG+CKE+I DG T Sbjct: 121 EDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTH 180 Query: 500 TFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVA 559 TFCGT +Y+APEI+ + ++VDWW+ G L+Y+ML G PF GE+ + I++ + Sbjct: 181 TFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLN 240 Query: 560 YPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKP 619 P +++EA + K L+ ++ RLG GP +++ H FFR+I+WE+L ++++PP+KP Sbjct: 241 LPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKP 300 Query: 620 KARDKRDTSNFDKEFTRQPVELTPTDKLFIMNLDQNEFAGFSY 662 + + D S FD +FTRQ +P D + +Q F F Y Sbjct: 301 LLQSEEDVSQFDSKFTRQTPVDSPDDST-LSEEEQEMFRDFEY 342 >5D9K-A nrPDB Length = 330 Score = 266 bits (681), Expect = 2e-71, Method: Compositional matrix adjust. Identities = 132/299 (44%), Positives = 190/299 (63%), Gaps = 5/299 (1%) Query: 340 TDFNFLMVLGKGSFGKVMLSER-KGTD--ELYAVKILKKDVVIQDDDVECTMVEKRVLAL 396 + F L VLG+GSFGKV L ++ G+D +LYA+K+LKK + D V M +R + + Sbjct: 30 SQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKM--ERDILV 87 Query: 397 PGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFF 456 PF+ +LH FQT +LY +++++ GGDL + + F E FY AE+A+ L Sbjct: 88 EVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDH 147 Query: 457 LQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQ 516 L S GIIYRDLK +N++LD EGHIK+ DFG+ KE+I +FCGT +Y+APE++ + Sbjct: 148 LHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRR 207 Query: 517 PYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLM 576 + +S DWW+FGVL++EML G PF+G+D E I++ + P+ +S EA ++ + L Sbjct: 208 GHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLF 267 Query: 577 TKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEFT 635 ++P RLG GP+G +IK H+FF IDW KL R+EI PP+KP DT FD EFT Sbjct: 268 KRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFT 326 >2Z7Q-A nrPDB Length = 321 Score = 261 bits (668), Expect = 5e-70, Method: Compositional matrix adjust. Identities = 130/295 (44%), Positives = 183/295 (62%), Gaps = 5/295 (1%) Query: 340 TDFNFLMVLGKGSFGKVMLSE---RKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLAL 396 + F L VLG+GSFGKV L R + LYA+K+LKK + D V M E+ +LA Sbjct: 28 SHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKM-ERDILA- 85 Query: 397 PGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFF 456 PF+ +LH FQT +LY +++++ GGDL + + F E FY AE+A+GL Sbjct: 86 DVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDH 145 Query: 457 LQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQ 516 L S GIIYRDLK +N++LD EGHIK+ DFG+ KE I +FCGT +Y+APE++ Q Sbjct: 146 LHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQ 205 Query: 517 PYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLM 576 + S DWW++GVL++EML G PF+G+D E I++ + P+ +S EA ++ + L Sbjct: 206 GHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALF 265 Query: 577 TKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFD 631 ++P RLG GP+G +IK H F+ IDW KL R+EI+PP+KP DT FD Sbjct: 266 KRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFD 320 >1VZO-A nrPDB Length = 355 Score = 253 bits (646), Expect = 2e-67, Method: Compositional matrix adjust. Identities = 138/349 (39%), Positives = 202/349 (57%), Gaps = 28/349 (8%) Query: 293 EGSEGNEELRQKFERAKIGQGTKAPEEKTANTISKFDNNGNRDRMKLTDFNFLMVLGKGS 352 +G +G E+L T E +TAN G+ +++ + +F L VLG G+ Sbjct: 24 DGGDGGEQLL-----------TVKHELRTANL------TGHAEKVGIENFELLKVLGTGA 66 Query: 353 FGKVMLSER---KGTDELYAVKILKKDVVIQD-DDVECTMVEKRVLALPGKPPFLTQLHS 408 +GKV L + T +LYA+K+LKK ++Q E T E++VL + PFL LH Sbjct: 67 YGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHY 126 Query: 409 CFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLK 468 FQT +L+ +++Y+NGG+L H+ Q RF E Y EI + L L GIIYRD+K Sbjct: 127 AFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIK 186 Query: 469 LDNVMLDSEGHIKIADFGMCKENIWDGVT-TKTFCGTPDYIAPEIIAYQPYG--KSVDWW 525 L+N++LDS GH+ + DFG+ KE + D FCGT +Y+AP+I+ G K+VDWW Sbjct: 187 LENILLDSNGHVVLTDFGLSKEFVADETERAYDFCGTIEYMAPDIVRGGDSGHDKAVDWW 246 Query: 526 AFGVLLYEMLAGQAPF----EGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPG 581 + GVL+YE+L G +PF E + E+ + I++ YP+ MS A + + L+ K P Sbjct: 247 SLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPK 306 Query: 582 KRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNF 630 KRLGCGP +IKEH FF+ I+W+ L K++ P+KP RD+ D SNF Sbjct: 307 KRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRDELDVSNF 355 >4RLP-A nrPDB Length = 288 Score = 248 bits (632), Expect = 7e-66, Method: Compositional matrix adjust. Identities = 117/282 (41%), Positives = 183/282 (64%), Gaps = 5/282 (1%) Query: 342 FNFLMVLGKGSFGKVMLSER---KGTDELYAVKILKKDVVIQD-DDVECTMVEKRVLALP 397 F L VLGKG +GKV + T +++A+K+LKK +++++ D T E+ +L Sbjct: 7 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILE-E 65 Query: 398 GKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFL 457 K PF+ L FQT +LY ++EY++GG+L +++ G F E A FY AEI++ L L Sbjct: 66 VKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHL 125 Query: 458 QSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQP 517 KGIIYRDLK +N+ML+ +GH+K+ DFG+CKE+I DG T TFCGT +Y+APEI+ Sbjct: 126 HQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSG 185 Query: 518 YGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMT 577 + ++VDWW+ G L+Y+ML G PF GE+ + I++ + P +++EA + K L+ Sbjct: 186 HNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLK 245 Query: 578 KHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKP 619 ++ RLG GP +++ H FFR+I+WE+L ++++PP+KP Sbjct: 246 RNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKP 287 >1FOT-A nrPDB Length = 318 Score = 246 bits (627), Expect = 3e-65, Method: Compositional matrix adjust. Identities = 121/298 (40%), Positives = 185/298 (62%), Gaps = 5/298 (1%) Query: 336 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 395 + L DF L LG GSFG+V L + YA+K+LKK++V++ VE T E+ +L+ Sbjct: 2 KYSLQDFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLS 61 Query: 396 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 455 + P F+ ++ FQ +++ +M+Y+ GG+L +++ RF P A FYAAE+ + L Sbjct: 62 IVTHP-FIIRMWGTFQDAQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALE 120 Query: 456 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAY 515 +L SK IIYRDLK +N++LD GHIKI DFG K + T T CGTPDYIAPE+++ Sbjct: 121 YLHSKDIIYRDLKPENILLDKNGHIKITDFGFAK---YVPDVTYTLCGTPDYIAPEVVST 177 Query: 516 QPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGL 575 +PY KS+DWW+FG+L+YEMLAG PF + + ++ I+ + +P +++ + L Sbjct: 178 KPYNKSIDWWSFGILIYEMLAGYTPFYDSNTMKTYEKILNAELRFPPFFNEDVKDLLSRL 237 Query: 576 MTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKR-DTSNFDK 632 +T+ +RLG G D+K H +F+ + WEKL + I+ PY+P + + DTS FDK Sbjct: 238 ITRDLSQRLGNLQNGTEDVKNHPWFKEVVWEKLLSRNIETPYEPPIQQGQGDTSQFDK 295 >5X3F-B nrPDB Length = 393 Score = 243 bits (621), Expect = 1e-64, Method: Compositional matrix adjust. Identities = 122/299 (40%), Positives = 182/299 (60%), Gaps = 4/299 (1%) Query: 333 NRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKR 392 +++ +L F+ + LG GSFG+VML + K + YA+KIL K V++ +E T+ EKR Sbjct: 77 SQNTAQLDQFDRIKTLGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQIEHTLNEKR 136 Query: 393 VLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAI 452 +L PFL +L F+ LY VMEYV GG++ H++++GRF EPHA FYAA+I + Sbjct: 137 ILQAVN-FPFLVKLEFSFKDNSNLYMVMEYVAGGEMFSHLRRIGRFSEPHARFYAAQIVL 195 Query: 453 GLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEI 512 +L S +IYRDLK +N+++D +G+I++ DFG K T T CGTP+Y+APEI Sbjct: 196 TFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV---KGRTWTLCGTPEYLAPEI 252 Query: 513 IAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAIC 572 I + Y K+VDWWA GVL+YEM AG PF + ++++ I+ V +P S + + Sbjct: 253 ILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLL 312 Query: 573 KGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFD 631 + L+ KR G G DIK H +F DW + +++++ P+ PK + DTSNFD Sbjct: 313 RNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFD 371 >5N23-A nrPDB Length = 352 Score = 243 bits (619), Expect = 2e-64, Method: Compositional matrix adjust. Identities = 123/293 (41%), Positives = 177/293 (60%), Gaps = 3/293 (1%) Query: 339 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 398 L F + LG GSFG+VML + K T YA+KIL K V++ +E T+ EKR+ Sbjct: 41 LDQFERIRTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRIQQAVN 100 Query: 399 KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQ 458 P FL +L F+ LY V+EY GG++ H++++GRF EPHA FYAA+I + +L Sbjct: 101 FP-FLVKLEFSFKDNSNLYMVLEYAPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLH 159 Query: 459 SKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY 518 S +IYRDLK +N+++D +G+IK+ADFG K G T T CGTP+Y+APEII + Y Sbjct: 160 SLDLIYRDLKPENLLIDQQGYIKVADFGFAKRV--KGRTPWTLCGTPEYLAPEIILSKGY 217 Query: 519 GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTK 578 K+VDWWA GVL+YEM AG PF + ++++ I+ V +P S + + + L+ Sbjct: 218 NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQV 277 Query: 579 HPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFD 631 KR G G DIK H +F DW + +++++ P+ PK + DTSNFD Sbjct: 278 DLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFD 330 >4WB7-A nrPDB Length = 405 Score = 241 bits (616), Expect = 5e-64, Method: Compositional matrix adjust. Identities = 123/293 (41%), Positives = 177/293 (60%), Gaps = 4/293 (1%) Query: 339 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 398 L F + LG GSFG+VML + K T YA+KIL K V++ +E T+ EKR+L Sbjct: 95 LDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVN 154 Query: 399 KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQ 458 PFL +L F+ LY VMEYV GG++ H++++GRF EPHA FYAA+I + +L Sbjct: 155 -FPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLH 213 Query: 459 SKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY 518 S +IYRDLK +N+++D +G+I++ DFG K T T CGTP+Y+APEII + Y Sbjct: 214 SLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV---KGRTWTLCGTPEYLAPEIILSKGY 270 Query: 519 GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTK 578 K+VDWWA GVL+YEM AG PF + ++++ I+ V +P S + + + L+ Sbjct: 271 NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQV 330 Query: 579 HPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFD 631 KR G G DIK H +F DW + +++++ P+ PK + DTSNFD Sbjct: 331 DLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFD 383 >4DNL-A nrPDB Length = 140 Score = 231 bits (589), Expect = 7e-61, Method: Compositional matrix adjust. Identities = 105/137 (76%), Positives = 122/137 (89%) Query: 155 HTERRGRIYIQAHIDREVLIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKT 214 HTE+RGRIY++A + E L V VRDAKNL+PMDPNGLSDPYVKLKLIPDPK+ESKQKTKT Sbjct: 2 HTEKRGRIYLKAEVADEKLHVTVRDAKNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKT 61 Query: 215 IKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKAGVDGW 274 I+ +LNP+WNE+F F+LK SDKDRRLSVEIWDWD T+RNDFMGSLSFG+SEL K GW Sbjct: 62 IRSTLNPQWNESFTFKLKPSDKDRRLSVEIWDWDRTTRNDFMGSLSFGVSELMKMPASGW 121 Query: 275 FKLLSQEEGEYFNVPVP 291 +KLL+QEEGEY+NVP+P Sbjct: 122 YKLLNQEEGEYYNVPIP 138 >5LOH-A nrPDB Length = 341 Score = 223 bits (567), Expect = 3e-58, Method: Compositional matrix adjust. Identities = 118/313 (37%), Positives = 189/313 (60%), Gaps = 19/313 (6%) Query: 339 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 398 + +F+ + + +G+FGKV L ++ G +LYAVK++KK +I + E+ LAL Sbjct: 35 IEEFSIVKPISRGAFGKVYLGQKGG--KLYAVKVVKKADMINKNMTHQVQAERDALAL-S 91 Query: 399 KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQ 458 K PF+ L+ Q+ + +Y VMEY+ GGD+ + G F E AV Y +E+A+ L +L Sbjct: 92 KSPFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALALDYLH 151 Query: 459 SKGIIYRDLKLDNVMLDSEGHIKIADFGMCKE------NIWDGVTTKTFCGTPDYIAPEI 512 GII+RDLK DN+++ +EGHIK+ DFG+ K N+ D +TT+TFCGTPDY+APE+ Sbjct: 152 RHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILTTRTFCGTPDYLAPEL 211 Query: 513 IAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKS---MSKEAV 569 + + +G +VDWWA GV L+E L G PF E ++FQ+I++ ++ +P+ +S A Sbjct: 212 LLGRAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILKRDIPWPEGEEKLSDNAQ 271 Query: 570 AICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSN 629 + + L+T KR G +++K H F +DWE L+ + + P+ P+ D+ DTS Sbjct: 272 SAVEILLTIDDTKRAGM-----KELKRHPLFSDVDWENLQHQTM--PFIPQPDDETDTSY 324 Query: 630 FDKEFTRQPVELT 642 F+ T Q + ++ Sbjct: 325 FEARNTAQHLTVS 337 >6BDL-A nrPDB Length = 347 Score = 206 bits (525), Expect = 2e-53, Method: Compositional matrix adjust. Identities = 113/298 (37%), Positives = 171/298 (57%), Gaps = 5/298 (1%) Query: 337 MKLTDFNFLMVLGKGSFGKVMLSERKGTD-ELYAVKILKKDVVIQDDDVECTMVEKRVLA 395 +KL+DFN + LG G FG+V L + K + + +A+KILKK ++ E EK+++ Sbjct: 31 LKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQ 90 Query: 396 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 455 F+ +L+ F+ LY +ME GG+L ++ G F++ FY A + Sbjct: 91 -GAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFA 149 Query: 456 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAY 515 +L SKGIIYRDLK +N++LD G+ K+ DFG K+ I G T TFCGTP+Y+APEII Sbjct: 150 YLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKK-IGFGKKTWTFCGTPEYVAPEIILN 208 Query: 516 QPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIME--HNVAYPKSMSKEAVAICK 573 + + S D+W+ G+L+YE+L G PF G D + + I+ + +PK ++K A + K Sbjct: 209 KGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIK 268 Query: 574 GLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFD 631 L +P +RLG G +DI++H +F +WE L + + PP P DTSNFD Sbjct: 269 KLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFD 326 >2UZP-A nrPDB Length = 144 Score = 206 bits (523), Expect = 4e-53, Method: Composition-based stats. Identities = 93/137 (67%), Positives = 115/137 (83%), Gaps = 1/137 (0%) Query: 155 HTERRGRIYIQAHI-DREVLIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTK 213 HTERRGR+ ++ + + V V +A+NL+PMDPNGLSDPYVKLKLIPDP++ +KQKT+ Sbjct: 3 HTERRGRLQLEIRAPTADEIHVTVGEARNLIPMDPNGLSDPYVKLKLIPDPRNLTKQKTR 62 Query: 214 TIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKAGVDG 273 T+K +LNP WNETF F LK D +RRLSVE+WDWD TSRNDFMG++SFG+SEL KA VDG Sbjct: 63 TVKATLNPVWNETFVFNLKPGDVERRLSVEVWDWDRTSRNDFMGAMSFGVSELLKAPVDG 122 Query: 274 WFKLLSQEEGEYFNVPV 290 W+KLL+QEEGEY+NVPV Sbjct: 123 WYKLLNQEEGEYYNVPV 139 >4TNB-A nrPDB Length = 590 Score = 203 bits (517), Expect = 2e-52, Method: Compositional matrix adjust. Identities = 118/315 (37%), Positives = 179/315 (56%), Gaps = 10/315 (3%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 F VLGKG FG+V + + T ++YA K L+K + + + EK++L Sbjct: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILE-KVNSQ 244 Query: 402 FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR--FKEPHAVFYAAEIAIGLFFLQS 459 F+ L ++T D L V+ +NGGDL +HI +G F+E A+FYAAEI GL L Sbjct: 245 FVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHH 304 Query: 460 KGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYG 519 + +YRDLK +N++LD GHI+I+D G+ + I +G + GT Y+APE++ Q YG Sbjct: 305 ENTVYRDLKPENILLDDYGHIRISDLGLAVK-IPEGDLIRGRVGTVGYMAPEVLNNQRYG 363 Query: 520 KSVDWWAFGVLLYEMLAGQAPFEGEDE----DELFQSIMEHNVAYPKSMSKEAVAICKGL 575 S D+W G L+YEM+ GQ+PF G E +E+ + ++E Y S+EA +ICK L Sbjct: 364 LSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKML 423 Query: 576 MTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDK--RDTSNFDKE 633 +TK +RLGC E ++K H FFR +++++LE + PP+ P R +D + ++ Sbjct: 424 LTKDAKQRLGCQEEEAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQF 483 Query: 634 FTRQPVELTPTDKLF 648 T + V L TD F Sbjct: 484 STVKGVNLDHTDDDF 498 >3NYO-A nrPDB Length = 576 Score = 201 bits (511), Expect = 1e-51, Method: Compositional matrix adjust. Identities = 119/315 (37%), Positives = 185/315 (58%), Gaps = 10/315 (3%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 F VLGKG FG+V + + T ++YA K L+K + + + EK++L Sbjct: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSR- 244 Query: 402 FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR--FKEPHAVFYAAEIAIGLFFLQS 459 F+ L ++T D L V+ +NGGDL +HI +G+ F E AVFYAAEI GL L Sbjct: 245 FVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHR 304 Query: 460 KGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYG 519 + I+YRDLK +N++LD GHI+I+D G+ ++ +G T K GT Y+APE++ + Y Sbjct: 305 ERIVYRDLKPENILLDDHGHIRISDLGLAV-HVPEGQTIKGRVGTVGYMAPEVVKNERYT 363 Query: 520 KSVDWWAFGVLLYEMLAGQAPFEGEDE----DELFQSIMEHNVAYPKSMSKEAVAICKGL 575 S DWWA G LLYEM+AGQ+PF+ + +E+ + + E Y + S +A ++C L Sbjct: 364 FSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQL 423 Query: 576 MTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYK--PKARDKRDTSNFDKE 633 + K P +RLGC R++KEH F+ +++++L ++PP+K P+A +D + ++ Sbjct: 424 LCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDIEQF 483 Query: 634 FTRQPVELTPTDKLF 648 T + VEL PTD+ F Sbjct: 484 STVKGVELEPTDQDF 498 >6E9W-A nrPDB Length = 443 Score = 199 bits (506), Expect = 4e-51, Method: Compositional matrix adjust. Identities = 131/353 (37%), Positives = 187/353 (52%), Gaps = 20/353 (5%) Query: 323 NTISKFDNNGN--RD-RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVI 379 N +S++ + N RD RMK D+ + V+G+G+FG+V L K T ++YA+K+L K +I Sbjct: 82 NFLSRYKDTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMI 141 Query: 380 QDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFK 439 + D E+ ++A P++ QL FQ LY VMEY+ GGDL+ ++ Sbjct: 142 KRSDSAFFWEERDIMAF-ANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLV-NLMSNYDVP 199 Query: 440 EPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMC-KENIWDGVTT 498 E A FY AE+ + L + S G I+RD+K DN++LD GH+K+ADFG C K N V Sbjct: 200 EKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRC 259 Query: 499 KTFCGTPDYIAPEIIAYQP----YGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIM 554 T GTPDYI+PE++ Q YG+ DWW+ GV LYEML G PF + + IM Sbjct: 260 DTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIM 319 Query: 555 EH--NVAYP--KSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLER 610 H ++ +P +SKEA + +T + + G G +IK H FF+ W Sbjct: 320 NHKNSLTFPDDNDISKEAKNLICAFLTD---REVRLGRNGVEEIKRHLFFKNDQWAWETL 376 Query: 611 KEIQPPYKPKARDKRDTSNFDK-EFTRQPVELTPTDKLFIMNLDQNEFAGFSY 662 ++ P P DTSNFD E + E P K F+ N Q F GF+Y Sbjct: 377 RDTVAPVVPDLSSDIDTSNFDDLEEDKGEEETFPIPKAFVGN--QLPFVGFTY 427 >4YHJ-A nrPDB Length = 584 Score = 199 bits (505), Expect = 4e-51, Method: Compositional matrix adjust. Identities = 112/284 (39%), Positives = 167/284 (58%), Gaps = 8/284 (2%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 F VLGKG FG+V + + T ++YA K L+K + + + EKR+L + Sbjct: 187 FRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE-KVQSR 245 Query: 402 FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR--FKEPHAVFYAAEIAIGLFFLQS 459 F+ L ++T D L V+ +NGGDL +HI +G F E AVFYAAE+ GL LQ Sbjct: 246 FVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQR 305 Query: 460 KGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYG 519 + I+YRDLK +N++LD GHI+I+D G+ E I +G + GT Y+APE++ + Y Sbjct: 306 ERIVYRDLKPENILLDDRGHIRISDLGLATE-IPEGQRVRGRVGTVGYMAPEVVNNEKYT 364 Query: 520 KSVDWWAFGVLLYEMLAGQAPFEGEDE----DELFQSIMEHNVAYPKSMSKEAVAICKGL 575 S DWW G L+YEM+ G +PF+ E +E+ Q I Y + S++A +IC+ L Sbjct: 365 FSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSICRML 424 Query: 576 MTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKP 619 +TK+P KRLGC EG +K+H F+ I++ +LE ++PP+ P Sbjct: 425 LTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCP 468 >3C51-A nrPDB Length = 543 Score = 197 bits (501), Expect = 1e-50, Method: Compositional matrix adjust. Identities = 113/284 (39%), Positives = 159/284 (55%), Gaps = 9/284 (3%) Query: 347 VLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQL 406 VLG+G FG+V + K T +LYA K L K + + + MVEK++LA F+ L Sbjct: 192 VLGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILA-KVHSRFIVSL 250 Query: 407 HSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR----FKEPHAVFYAAEIAIGLFFLQSKGI 462 F+T L VM +NGGD+ YHI V F+EP A+FY A+I GL L + I Sbjct: 251 AYAFETKTDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQIVSGLEHLHQRNI 310 Query: 463 IYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSV 522 IYRDLK +NV+LD +G+++I+D G+ E TK + GTP ++APE++ + Y SV Sbjct: 311 IYRDLKPENVLLDDDGNVRISDLGLAVELKAGQTKTKGYAGTPGFMAPELLLGEEYDFSV 370 Query: 523 DWWAFGVLLYEMLAGQAPFEGEDE----DELFQSIMEHNVAYPKSMSKEAVAICKGLMTK 578 D++A GV LYEM+A + PF E EL Q ++E V YP S + C+ L+ K Sbjct: 371 DYFALGVTLYEMIAARGPFRARGEKVENKELKQRVLEQAVTYPDKFSPASKDFCEALLQK 430 Query: 579 HPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKAR 622 P KRLG ++ H FR I W +LE + PP+ P +R Sbjct: 431 DPEKRLGFRDGSCDGLRTHPLFRDISWRQLEAGMLTPPFVPDSR 474 >6ED6-A nrPDB Length = 415 Score = 197 bits (501), Expect = 1e-50, Method: Compositional matrix adjust. Identities = 122/337 (36%), Positives = 184/337 (54%), Gaps = 17/337 (5%) Query: 336 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 395 +MK D++ + V+G+G+FG+V L K + ++YA+K+L K +I+ D E+ ++A Sbjct: 84 QMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMA 143 Query: 396 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 455 P++ QL FQ LY VMEY+ GGDL+ ++ E A FY AE+ + L Sbjct: 144 F-ANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLV-NLMSNYDVPEKWAKFYTAEVVLALD 201 Query: 456 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDG-VTTKTFCGTPDYIAPEIIA 514 + S G+I+RD+K DN++LD GH+K+ADFG C + G V T GTPDYI+PE++ Sbjct: 202 AIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLK 261 Query: 515 YQP----YGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEH--NVAYPKS--MSK 566 Q YG+ DWW+ GV LYEML G PF + + IM+H ++ +P+ +SK Sbjct: 262 SQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISK 321 Query: 567 EAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRD 626 A + +T + + G G +I++H FF+ W +E P P+ D Sbjct: 322 HAKNLICAFLTD---REVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDID 378 Query: 627 TSNFDK-EFTRQPVELTPTDKLFIMNLDQNEFAGFSY 662 +SNFD E + VE P K F+ N Q F GF+Y Sbjct: 379 SSNFDDIEDDKGDVETFPIPKAFVGN--QLPFIGFTY 413 >4AW2-A nrPDB Length = 437 Score = 193 bits (491), Expect = 2e-49, Method: Compositional matrix adjust. Identities = 119/342 (34%), Positives = 181/342 (52%), Gaps = 19/342 (5%) Query: 336 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 395 R+ DF L V+G+G+FG+V + + K D+++A+KIL K +++ + C E+ VL Sbjct: 70 RLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVL- 128 Query: 396 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQV-GRFKEPHAVFYAAEIAIGL 454 + G ++T LH FQ + LY VM+Y GGDL+ + + R E A FY AE+ I + Sbjct: 129 VNGDSKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEEMARFYLAEMVIAI 188 Query: 455 FFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDG-VTTKTFCGTPDYIAPEII 513 + ++RD+K DN+++D GHI++ADFG C + + DG V + GTPDYI+PEI+ Sbjct: 189 DSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEIL 248 Query: 514 AYQP-----YGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEH--NVAYPKS--- 563 YG DWW+ GV +YEML G+ PF E E + IM H +P Sbjct: 249 QAMEGGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPTQVTD 308 Query: 564 MSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARD 623 +S+ A + + L+ + G G D K+H FF IDW+ + + + PY P+ Sbjct: 309 VSENAKDLIRRLICSREHR---LGQNGIEDFKKHPFFSGIDWDNI--RNCEAPYIPEVSS 363 Query: 624 KRDTSNFD-KEFTRQPVELTPTDKLFIMNLDQNEFAGFSYTN 664 DTSNFD + + E P + F GF+YT+ Sbjct: 364 PTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYTS 405 >5FET-A nrPDB Length = 847 Score = 192 bits (489), Expect = 3e-49, Method: Compositional matrix adjust. Identities = 105/297 (35%), Positives = 168/297 (56%), Gaps = 14/297 (4%) Query: 335 DRMKLTDFNFLM-------VLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECT 387 +R+K+ D M ++G+G+FG V L K T YA+K + K +I + Sbjct: 521 ERIKMQDTKVEMHELETERIIGRGTFGTVKLVHHKPTQIRYALKCVSKRSIISLNQQNNI 580 Query: 388 MVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYA 447 +E+ + A PF+ +L F+ + YF+ E V GG+L I+++G +P A FY Sbjct: 581 KLEREITA-ENDHPFIIRLVRTFKDSNCFYFLTELVTGGELYDAIRKLGLLSKPQAQFYL 639 Query: 448 AEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDY 507 I + + +L + I+YRDLK +N++LD +G++K+ DFG C + I T GTP Y Sbjct: 640 GSIILAIEYLHERNIVYRDLKPENILLDKQGYVKLIDFG-CAKKIQG--RAYTLVGTPHY 696 Query: 508 IAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDED--ELFQSIMEHNVAYPKSMS 565 +APE+I + YG +VD WA GV LYE + G PF + ED E+F+ I+ + +P +S Sbjct: 697 MAPEVILGKGYGCTVDIWALGVCLYEFICGPLPFGNDQEDQLEIFRDILTGQLTFPDYVS 756 Query: 566 -KEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKA 621 ++++ + K L+ + P R+GC G +DIKEHAFF +W+KL + ++PP K Sbjct: 757 DQDSINLMKRLLCRLPQGRIGCSINGFKDIKEHAFFGNFNWDKLAGRLLEPPLVSKG 813 >3TKU-A nrPDB Length = 433 Score = 191 bits (485), Expect = 1e-48, Method: Compositional matrix adjust. Identities = 120/338 (35%), Positives = 180/338 (53%), Gaps = 21/338 (6%) Query: 341 DFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKP 400 DF + V+G+G+FG+V + + K T+ +YA+KIL K +++ + C E+ VL + G Sbjct: 91 DFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVL-VNGDC 149 Query: 401 PFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQV-GRFKEPHAVFYAAEIAIGLFFLQS 459 ++T LH FQ + LY VM+Y GGDL+ + + + E A FY E+ + + + Sbjct: 150 QWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIHQ 209 Query: 460 KGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDG-VTTKTFCGTPDYIAPEII----- 513 ++RD+K DNV+LD GHI++ADFG C + DG V + GTPDYI+PEI+ Sbjct: 210 LHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQAMED 269 Query: 514 AYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNV-----AYPKSMSKEA 568 YG DWW+ GV +YEML G+ PF E E + IM H ++ +S+EA Sbjct: 270 GMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVTDVSEEA 329 Query: 569 VAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTS 628 + + L+ +RL G G D K+HAFF ++WE + + ++ PY P DTS Sbjct: 330 KDLIQRLICSRE-RRL--GQNGIEDFKKHAFFEGLNWENI--RNLEAPYIPDVSSPSDTS 384 Query: 629 NF--DKEFTRQPVELTPTDKLFIMNLDQNEFAGFSYTN 664 NF D + R L P L F GF++T Sbjct: 385 NFDVDDDVLRNTEILPPGSHTGFSGL-HLPFIGFTFTT 421 >5UUU-A nrPDB Length = 547 Score = 189 bits (479), Expect = 5e-48, Method: Compositional matrix adjust. Identities = 106/327 (32%), Positives = 181/327 (55%), Gaps = 14/327 (4%) Query: 337 MKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLAL 396 + + DF+ ++G+G FG+V + T ++YA+K L K + + E+ +L+L Sbjct: 195 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 254 Query: 397 --PGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGL 454 G PF+ + F T D+L F+++ +NGGDL YH+ Q G F E FYAAEI +GL Sbjct: 255 VSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGL 314 Query: 455 FFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA 514 + ++ ++YRDLK N++LD GH++I+D G+ + + GT Y+APE++ Sbjct: 315 EHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACD--FSKKKPHASVGTHGYMAPEVLQ 372 Query: 515 YQ-PYGKSVDWWAFGVLLYEMLAGQAPF---EGEDEDELFQSIMEHNVAYPKSMSKEAVA 570 Y S DW++ G +L+++L G +PF + +D+ E+ + + V P S S E + Sbjct: 373 KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRS 432 Query: 571 ICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKP-----KARDKR 625 + +GL+ + +RLGC G +++KE FFR +DW+ + ++ PP P A D Sbjct: 433 LLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAF 492 Query: 626 DTSNFDKEFTRQPVELTPTDKLFIMNL 652 D +FD+E T+ ++L +D+ N Sbjct: 493 DIGSFDEEDTKG-IKLLDSDQELYRNF 518 >3PVW-A nrPDB Length = 695 Score = 188 bits (478), Expect = 6e-48, Method: Compositional matrix adjust. Identities = 106/327 (32%), Positives = 181/327 (55%), Gaps = 14/327 (4%) Query: 337 MKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLAL 396 + + DF+ ++G+G FG+V + T ++YA+K L K + + E+ +L+L Sbjct: 186 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 245 Query: 397 --PGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGL 454 G PF+ + F T D+L F+++ +NGGDL YH+ Q G F E FYAAEI +GL Sbjct: 246 VSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGL 305 Query: 455 FFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA 514 + ++ ++YRDLK N++LD GH++I+D G+ + + GT Y+APE++ Sbjct: 306 EHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACD--FSKKKPHASVGTHGYMAPEVLQ 363 Query: 515 YQ-PYGKSVDWWAFGVLLYEMLAGQAPF---EGEDEDELFQSIMEHNVAYPKSMSKEAVA 570 Y S DW++ G +L+++L G +PF + +D+ E+ + + V P S S E + Sbjct: 364 KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRS 423 Query: 571 ICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKP-----KARDKR 625 + +GL+ + +RLGC G +++KE FFR +DW+ + ++ PP P A D Sbjct: 424 LLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAF 483 Query: 626 DTSNFDKEFTRQPVELTPTDKLFIMNL 652 D +FD+E T+ ++L +D+ N Sbjct: 484 DIGSFDEEDTK-GIKLLDSDQELYRNF 509 >3ORZ-A nrPDB Length = 316 Score = 186 bits (471), Expect = 4e-47, Method: Compositional matrix adjust. Identities = 105/307 (34%), Positives = 168/307 (54%), Gaps = 6/307 (1%) Query: 313 GTKAPEEKTANTISKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKI 372 GT A A ++ + + DF F +LG+GSF V+L+ T YA+KI Sbjct: 10 GTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKI 69 Query: 373 LKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHI 432 L+K +I+++ V E+ V++ P F +L+ CFQ ++LYF + Y G+L+ +I Sbjct: 70 LEKRHIIKENKVPYVTRERDVMSRLDHP-FFVKLYFCFQDDEKLYFGLSYAKNGELLKYI 128 Query: 433 QQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENI 492 +++G F E FY AEI L +L KGII+RDLK +N++L+ + HI+I DFG K Sbjct: 129 RKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLS 188 Query: 493 WDGVTTK--TFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELF 550 + + +F GT Y++PE++ + KS D WA G ++Y+++AG PF +E +F Sbjct: 189 PESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIF 248 Query: 551 QSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGP-EGERDIKEHAFFRYIDWEKLE 609 Q I++ +P+ +A + + L+ KRLGC EG +K H FF + WE L Sbjct: 249 QKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLH 308 Query: 610 RKEIQPP 616 ++ PP Sbjct: 309 QQ--TPP 313 >5DYK-A nrPDB Length = 853 Score = 183 bits (465), Expect = 2e-46, Method: Compositional matrix adjust. Identities = 99/297 (33%), Positives = 165/297 (55%), Gaps = 14/297 (4%) Query: 335 DRMKLTDFNFLM-------VLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECT 387 +R+K+ D M ++G+G+FG V L K T YA+K + K +I + Sbjct: 527 ERIKMQDTKVEMDELETERIIGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINLNQQNNI 586 Query: 388 MVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYA 447 +E+ + A PF+ +L F+ YF+ E V GG+L I+++G + A FY Sbjct: 587 KLEREITA-ENDHPFIIRLVRTFKDSKYFYFLTELVTGGELYDAIRKLGLLSKSQAQFYL 645 Query: 448 AEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDY 507 I + + +L + I+YRDLK +N++LD +G++K+ DFG C + + T GTP Y Sbjct: 646 GSIILAIEYLHERNIVYRDLKPENILLDKQGYVKLIDFG-CAKKVQG--RAYTLVGTPHY 702 Query: 508 IAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDED--ELFQSIMEHNVAYPKSMS 565 +APE+I + YG +VD WA G+ LYE + G PF ++ED E+F+ I+ + +P ++ Sbjct: 703 MAPEVILGKGYGCTVDIWALGICLYEFICGPLPFGNDEEDQLEIFRDILTGQLTFPDYVT 762 Query: 566 -KEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKA 621 +++ + K L+ + P R+GC G +DIK+H FF +W+KL + + PP K+ Sbjct: 763 DTDSINLMKRLLCRLPQGRIGCSINGFKDIKDHPFFSNFNWDKLAGRLLDPPLVSKS 819 >2VD5-A nrPDB Length = 412 Score = 180 bits (456), Expect = 2e-45, Method: Compositional matrix adjust. Identities = 115/310 (37%), Positives = 172/310 (55%), Gaps = 20/310 (6%) Query: 336 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 395 R++ DF L V+G+G+F +V + + K T ++YA+KI+ K +++ +V C E+ VL Sbjct: 57 RLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVL- 115 Query: 396 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVG-RFKEPHAVFYAAEIAIGL 454 + G ++TQLH FQ + LY VMEY GGDL+ + + G R A FY AEI + + Sbjct: 116 VNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAI 175 Query: 455 FFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDG-VTTKTFCGTPDYIAPEII 513 + G ++RD+K DN++LD GHI++ADFG C + DG V + GTPDY++PEI+ Sbjct: 176 DSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEIL 235 Query: 514 -------AYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEH--NVAYP--- 561 YG DWWA GV YEM GQ PF + E + I+ + +++ P Sbjct: 236 QAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVD 295 Query: 562 KSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKA 621 + + +EA + L+ P RLG G G D + H FF +DW+ L ++ PP+ P Sbjct: 296 EGVPEEARDFIQRLLCP-PETRLGRG--GAGDFRTHPFFFGLDWDGL--RDSVPPFTPDF 350 Query: 622 RDKRDTSNFD 631 DT NFD Sbjct: 351 EGATDTCNFD 360 >6BXI-A nrPDB Length = 333 Score = 167 bits (423), Expect = 1e-41, Method: Compositional matrix adjust. Identities = 106/340 (31%), Positives = 170/340 (50%), Gaps = 53/340 (15%) Query: 336 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 395 R+ L DF L V+G+G+FG+V L ++K T +YA+KIL+K +++ + V E+ +L Sbjct: 2 RLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDIL- 60 Query: 396 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 455 + ++ ++ FQ LY +ME++ GGD+M + + E FY AE + + Sbjct: 61 VEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAID 120 Query: 456 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCK------------------------EN 491 + G I+RD+K DN++LDS+GH+K++DFG+C +N Sbjct: 121 SIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQN 180 Query: 492 IWDGVTTKTF-----------CGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAP 540 + +T+ GTPDYIAPE+ Y K DWW+ GV++YEML G P Sbjct: 181 MNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPP 240 Query: 541 FEGEDEDELFQSIM--EHNVAYPKSMSKEAVAICKGLMTKHPGKRLGC------GPEGER 592 F E E ++ +M + + +P + A K L+ R C G G Sbjct: 241 FCSETPQETYKKVMNWKETLTFPPEVPISEKA--KDLIL-----RFCCEWEHRIGAPGVE 293 Query: 593 DIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFDK 632 +IK ++FF +DWE + + + K+ D DTSNFD+ Sbjct: 294 EIKSNSFFEGVDWEHIRERPAAISIEIKSID--DTSNFDE 331 >4FR4-A nrPDB Length = 384 Score = 163 bits (412), Expect = 2e-40, Method: Compositional matrix adjust. Identities = 93/298 (31%), Positives = 158/298 (53%), Gaps = 15/298 (5%) Query: 328 FDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECT 387 FD N + + F L +GKGSFGKV + ++ T ++YA+K + K ++ ++V Sbjct: 6 FDENED---VNFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNV 62 Query: 388 MVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYA 447 E +++ + PFL L FQ + ++ V++ + GGDL YH+QQ FKE + Sbjct: 63 FKELQIMQ-GLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFI 121 Query: 448 AEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDY 507 E+ + L +LQ++ II+RD+K DN++LD GH+ I DF + + T T GT Y Sbjct: 122 CELVMALDYLQNQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQIT-TMAGTKPY 180 Query: 508 IAPEIIAYQP---YGKSVDWWAFGVLLYEMLAGQAPFE---GEDEDELFQSIMEHNVAYP 561 +APE+ + + Y +VDWW+ GV YE+L G+ P+ E+ + V YP Sbjct: 181 MAPEMFSSRKGAGYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHTFETTVVTYP 240 Query: 562 KSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKP 619 + S+E V++ K L+ +P +R D++ + I+W+ + +K + P + P Sbjct: 241 SAWSQEMVSLLKKLLEPNPDQRFS----QLSDVQNFPYMNDINWDAVFQKRLIPGFIP 294 >4C0T-A nrPDB Length = 974 Score = 162 bits (410), Expect = 4e-40, Method: Compositional matrix adjust. Identities = 100/325 (30%), Positives = 167/325 (51%), Gaps = 16/325 (4%) Query: 293 EGSEGNEELRQKFERAKIGQGTKAPEEKTA--NTISKFDNNGNRDRMKLTDFNFLMVLGK 350 E E N++ + + + Q + E+K A TI D R +TDF F LG+ Sbjct: 217 EEEENNDDTDEIPKSETLKQNEENWEKKGAAVKTIKTMDGEMKTIRRNVTDFKFGKELGE 276 Query: 351 GSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCF 410 GS+ V+L+ K T + YAVK+L K +I++ V+ +EK L + L+ F Sbjct: 277 GSYSTVILATDKITGKQYAVKVLDKRHIIKEKKVKYVNIEKHALNRLSNRLGVISLYFTF 336 Query: 411 QTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLD 470 Q D LYFV++Y + G+L+ I++ E + A+I + ++ G+I+RDLK + Sbjct: 337 QDKDSLYFVLDYASNGELLTLIKRYNTLNEECTRHFGAQILDAIKYMHDNGVIHRDLKPE 396 Query: 471 NVMLDSEGHIKIADFGMCK---------ENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKS 521 N++LD + I+I DFG + E V K+F GT +Y++PE++ + GK Sbjct: 397 NILLDDKMRIQITDFGTARLLEKKNDESEEYPVDVRAKSFVGTAEYVSPELLENKYCGKP 456 Query: 522 VDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPG 581 D WAFG ++Y+M+AG+ PF+ +E FQ I + A+ + K ++ P Sbjct: 457 GDVWAFGCIIYQMIAGKPPFKATNEYLTFQKITKLQFAFSAGFPTIIRDLIKKILVLQPS 516 Query: 582 KRLGCGPEGERDIKEHAFFRYIDWE 606 +R PE I++H FF+ +D++ Sbjct: 517 RR-ATIPE----IQKHYFFQSVDFK 536 >2JC6-A nrPDB Length = 334 Score = 149 bits (376), Expect = 4e-36, Method: Compositional matrix adjust. Identities = 89/253 (35%), Positives = 139/253 (54%), Gaps = 13/253 (5%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVK-ILKKDVVIQDDDVECTMVEKRVLALPGKP 400 F F LG G+F +V+L+E K T +L+AVK I KK + ++ +E + R + K Sbjct: 24 FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKI----KH 79 Query: 401 PFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSK 460 + L +++ + LY VM+ V+GG+L I + G + E A ++ +++L Sbjct: 80 ENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRM 139 Query: 461 GIIYRDLKLDNVML---DSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQP 517 GI++RDLK +N++ D E I I+DFG+ K G T CGTP Y+APE++A +P Sbjct: 140 GIVHRDLKPENLLYYSQDEESKIMISDFGLSKME-GKGDVMSTACGTPGYVAPEVLAQKP 198 Query: 518 YGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIM----EHNVAYPKSMSKEAVAICK 573 Y K+VD W+ GV+ Y +L G PF E++ +LF+ I+ E + Y +S A + Sbjct: 199 YSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIR 258 Query: 574 GLMTKHPGKRLGC 586 LM K P KR C Sbjct: 259 NLMEKDPNKRYTC 271 >2ELI-A nrPDB Length = 85 Score = 145 bits (367), Expect = 4e-35, Method: Compositional matrix adjust. Identities = 64/76 (84%), Positives = 71/76 (93%) Query: 93 PASDDPRSKHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCG 152 P +DDPRSKHKFKIHTY SPTFCDHCGSLLYGLIHQGMKCDTC MNVHK+CV+NVPSLCG Sbjct: 9 PDTDDPRSKHKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDTCDMNVHKQCVINVPSLCG 68 Query: 153 TDHTERRGRIYIQAHI 168 DHTE+RGRIY++A + Sbjct: 69 MDHTEKRGRIYLKAEV 84 Score = 46.6 bits (109), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 18/42 (42%), Positives = 23/42 (54%) Query: 37 HKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRC 78 HKF + PTFC HC ++G QG +C C VHK+C Sbjct: 18 HKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDTCDMNVHKQC 59 >4FG9-A nrPDB Length = 320 Score = 143 bits (361), Expect = 2e-34, Method: Compositional matrix adjust. Identities = 86/252 (34%), Positives = 139/252 (55%), Gaps = 11/252 (4%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 ++F VLG G+F +V+L+E K T +L A+K + K+ + + E +M + + K P Sbjct: 20 YDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEAL---EGKEGSMENEIAVLHKIKHP 76 Query: 402 FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKG 461 + L +++ LY +M+ V+GG+L I + G + E A ++ + +L G Sbjct: 77 NIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLG 136 Query: 462 IIYRDLKLDNVM---LDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY 518 I++RDLK +N++ LD + I I+DFG+ K G T CGTP Y+APE++A +PY Sbjct: 137 IVHRDLKPENLLYYSLDEDSKIMISDFGLSKMED-PGSVLSTACGTPGYVAPEVLAQKPY 195 Query: 519 GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIM----EHNVAYPKSMSKEAVAICKG 574 K+VD W+ GV+ Y +L G PF E++ +LF+ I+ E + Y +S A + Sbjct: 196 SKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIRH 255 Query: 575 LMTKHPGKRLGC 586 LM K P KR C Sbjct: 256 LMEKDPEKRFTC 267 >5ES1-A nrPDB Length = 328 Score = 141 bits (356), Expect = 7e-34, Method: Compositional matrix adjust. Identities = 81/244 (33%), Positives = 129/244 (52%), Gaps = 4/244 (1%) Query: 341 DFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKP 400 ++ L +GKG+F KV L+ T A+KI+ K + ++ E R++ P Sbjct: 16 NYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDK-TQLNPSSLQKLFREVRIMKGLNHP 74 Query: 401 PFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSK 460 + +L +T LY VMEY + G++ ++ GR KE A +I + + K Sbjct: 75 N-IVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQK 133 Query: 461 GIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY-G 519 I++RDLK +N++LD+E +IKIADFG E G TFCG+P Y APE+ + Y G Sbjct: 134 NIVHRDLKAENLLLDAEANIKIADFGFSNEFTL-GSKLDTFCGSPPYAAPELFQGKKYDG 192 Query: 520 KSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKH 579 VD W+ GV+LY +++G PF+G + EL + ++ P MS + +I + + + Sbjct: 193 PEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLN 252 Query: 580 PGKR 583 P KR Sbjct: 253 PAKR 256 >4REW-A nrPDB Length = 540 Score = 141 bits (356), Expect = 9e-34, Method: Compositional matrix adjust. Identities = 86/256 (33%), Positives = 141/256 (55%), Gaps = 8/256 (3%) Query: 347 VLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQL 406 LG G+FGKV + + + T AVKIL + + D V E + L L + P + +L Sbjct: 13 TLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKL-FRHPHIIKL 71 Query: 407 HSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRD 466 + T ++ VMEYV+GG+L +I + GR E + +I G+ + +++RD Sbjct: 72 YQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRD 131 Query: 467 LKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY-GKSVDWW 525 LK +NV+LD+ + KIADFG+ + DG +T CG+P+Y APE+I+ + Y G VD W Sbjct: 132 LKPENVLLDAHMNAKIADFGL-SNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIW 190 Query: 526 AFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLG 585 + GV+LY +L G PF+ + LF+ I + P+ ++ +++ K ++ P KR Sbjct: 191 SSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRAS 250 Query: 586 CGPEGERDIKEHAFFR 601 +DI+EH +F+ Sbjct: 251 I-----KDIREHEWFK 261 >4CFH-A nrPDB Length = 493 Score = 141 bits (355), Expect = 9e-34, Method: Compositional matrix adjust. Identities = 88/267 (32%), Positives = 146/267 (54%), Gaps = 8/267 (2%) Query: 336 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 395 R+K+ + LG G+FGKV + + + T AVKIL + + D V E + L Sbjct: 29 RVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLK 88 Query: 396 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 455 L + P + +L+ T ++ VMEYV+GG+L +I + GR E + +I G+ Sbjct: 89 L-FRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVD 147 Query: 456 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAY 515 + +++RDLK +NV+LD+ + KIADFG+ + DG +T CG+P+Y APE+I+ Sbjct: 148 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSN-MMSDGEFLRTSCGSPNYAAPEVISG 206 Query: 516 QPY-GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKG 574 + Y G VD W+ GV+LY +L G PF+ + LF+ I + P+ ++ +++ K Sbjct: 207 RLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKH 266 Query: 575 LMTKHPGKRLGCGPEGERDIKEHAFFR 601 ++ P KR +DI+EH +F+ Sbjct: 267 MLQVDPMKRATI-----KDIREHEWFK 288 >5KZ7-A nrPDB Length = 346 Score = 141 bits (355), Expect = 1e-33, Method: Compositional matrix adjust. Identities = 82/246 (33%), Positives = 134/246 (54%), Gaps = 4/246 (1%) Query: 339 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 398 + ++ L +GKG+F KV L+ T + AVKI+ K + ++ E R++ + Sbjct: 32 IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDK-TQLNSSSLQKLFREVRIMKVLN 90 Query: 399 KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQ 458 P + +L +T LY VMEY +GG++ ++ GR KE A +I + + Sbjct: 91 HPN-IVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCH 149 Query: 459 SKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY 518 K I++RDLK +N++LD++ +IKIADFG E + G TFCG+P Y APE+ + Y Sbjct: 150 QKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTF-GNKLDTFCGSPPYAAPELFQGKKY 208 Query: 519 -GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMT 577 G VD W+ GV+LY +++G PF+G++ EL + ++ P MS + + K + Sbjct: 209 DGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLI 268 Query: 578 KHPGKR 583 +P KR Sbjct: 269 LNPSKR 274 >1TBN-A nrPDB Length = 82 Score = 140 bits (353), Expect = 2e-33, Method: Composition-based stats. Identities = 56/74 (75%), Positives = 67/74 (90%) Query: 92 GPASDDPRSKHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLC 151 GP +DDPR+KHKF++H+YSSPTFCDHCGSLLYGL+HQGMKC C MNVH+RCV +VPSLC Sbjct: 1 GPQTDDPRNKHKFRLHSYSSPTFCDHCGSLLYGLVHQGMKCSCCEMNVHRRCVRSVPSLC 60 Query: 152 GTDHTERRGRIYIQ 165 G DHTERRGR+ ++ Sbjct: 61 GVDHTERRGRLQLE 74 Score = 50.1 bits (118), Expect = 3e-06, Method: Composition-based stats. Identities = 20/50 (40%), Positives = 25/50 (50%) Query: 37 HKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSC 86 HKF + PTFC HC ++G QG +C C VH+RC V C Sbjct: 11 HKFRLHSYSSPTFCDHCGSLLYGLVHQGMKCSCCEMNVHRRCVRSVPSLC 60 >4RED-A nrPDB Length = 351 Score = 139 bits (351), Expect = 3e-33, Method: Compositional matrix adjust. Identities = 86/255 (33%), Positives = 141/255 (55%), Gaps = 8/255 (3%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 407 LG G+FGKV + + + T AVKIL + + D V E + L L + P + +L+ Sbjct: 22 LGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLDVVGKIRREIQNLKL-FRHPHIIKLY 80 Query: 408 SCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDL 467 T ++ VMEYV+GG+L +I + GR E + +I G+ + +++RDL Sbjct: 81 QVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDL 140 Query: 468 KLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY-GKSVDWWA 526 K +NV+LD+ + KIADFG+ + DG +T CG+P+Y APE+I+ + Y G VD W+ Sbjct: 141 KPENVLLDAHMNAKIADFGL-SNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWS 199 Query: 527 FGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGC 586 GV+LY +L G PF+ + LF+ I + P+ ++ +++ K ++ P KR Sbjct: 200 SGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRASI 259 Query: 587 GPEGERDIKEHAFFR 601 +DI+EH +F+ Sbjct: 260 -----KDIREHEWFK 269 >5EZV-A nrPDB Length = 560 Score = 139 bits (350), Expect = 4e-33, Method: Compositional matrix adjust. Identities = 89/267 (33%), Positives = 142/267 (53%), Gaps = 8/267 (2%) Query: 336 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 395 R+K+ + LG G+FGKV + E + T AVKIL + + D V E + L Sbjct: 24 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK 83 Query: 396 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 455 L + P + +L+ T + VMEYV+GG+L +I + GR +E A +I + Sbjct: 84 L-FRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVD 142 Query: 456 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAY 515 + +++RDLK +NV+LD+ + KIADFG+ + DG +T CG+P+Y APE+I+ Sbjct: 143 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSN-MMSDGEFLRTSCGSPNYAAPEVISG 201 Query: 516 QPY-GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKG 574 + Y G VD W+ GV+LY +L G PF+ E LF+ I P+ +++ + Sbjct: 202 RLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMH 261 Query: 575 LMTKHPGKRLGCGPEGERDIKEHAFFR 601 ++ P KR +DI+EH +F+ Sbjct: 262 MLQVDPLKRATI-----KDIREHEWFK 283 >4CFF-A nrPDB Length = 571 Score = 139 bits (349), Expect = 5e-33, Method: Compositional matrix adjust. Identities = 89/267 (33%), Positives = 142/267 (53%), Gaps = 8/267 (2%) Query: 336 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 395 R+K+ + LG G+FGKV + E + T AVKIL + + D V E + L Sbjct: 29 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK 88 Query: 396 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 455 L + P + +L+ T + VMEYV+GG+L +I + GR +E A +I + Sbjct: 89 L-FRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVD 147 Query: 456 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAY 515 + +++RDLK +NV+LD+ + KIADFG+ + DG +T CG+P+Y APE+I+ Sbjct: 148 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGL-SNMMSDGEFLRTSCGSPNYAAPEVISG 206 Query: 516 QPY-GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKG 574 + Y G VD W+ GV+LY +L G PF+ E LF+ I P+ +++ + Sbjct: 207 RLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMH 266 Query: 575 LMTKHPGKRLGCGPEGERDIKEHAFFR 601 ++ P KR +DI+EH +F+ Sbjct: 267 MLQVDPLKRATI-----KDIREHEWFK 288 >2QNJ-A nrPDB Length = 328 Score = 138 bits (347), Expect = 9e-33, Method: Compositional matrix adjust. Identities = 81/253 (32%), Positives = 136/253 (53%), Gaps = 4/253 (1%) Query: 332 GNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEK 391 G+ ++ + ++ L +GKG+F KV L+ T A+KI+ K + ++ E Sbjct: 4 GSDEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDK-TQLNPTSLQKLFREV 62 Query: 392 RVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIA 451 R++ + P + +L +T LY +MEY +GG++ ++ GR KE A +I Sbjct: 63 RIMKILNHPN-IVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIV 121 Query: 452 IGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPE 511 + + K I++RDLK +N++LD++ +IKIADFG E G TFCG+P Y APE Sbjct: 122 SAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGG-KLDTFCGSPPYAAPE 180 Query: 512 IIAYQPY-GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVA 570 + + Y G VD W+ GV+LY +++G PF+G++ EL + ++ P MS + Sbjct: 181 LFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCEN 240 Query: 571 ICKGLMTKHPGKR 583 + K + +P KR Sbjct: 241 LLKRFLVLNPIKR 253 >3D2K-A nrPDB Length = 272 Score = 137 bits (346), Expect = 1e-32, Method: Compositional matrix adjust. Identities = 82/270 (30%), Positives = 137/270 (50%), Gaps = 8/270 (2%) Query: 332 GNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEK 391 G++ + L DF+ LGKG FG V L+ + + + A+K+L K ++ VE + + Sbjct: 4 GSKRQWTLEDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFK-TQLEKAGVEHQLRRE 62 Query: 392 RVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIA 451 + + P + +L+ F R+Y ++EY G + +Q++ RF E Y E+A Sbjct: 63 VEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSRFDEQRTATYITELA 122 Query: 452 IGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPE 511 L + SK +I+RD+K +N++L S G +KIADFG T T CGT DY+ PE Sbjct: 123 NALSYCHSKRVIHRDIKPENLLLGSNGELKIADFGWSVHAPSSRRT--TLCGTLDYLPPE 180 Query: 512 IIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAI 571 +I + + + VD W+ GVL YE L G PFE E ++ I +P +++ A + Sbjct: 181 MIEGRMHDEKVDLWSLGVLCYEFLVGMPPFEAHTYQETYRRISRVEFTFPDFVTEGARDL 240 Query: 572 CKGLMTKHPGKRLGCGPEGERDIKEHAFFR 601 L+ + +RL ++ EH + + Sbjct: 241 ISRLLKHNASQRLTLA-----EVLEHPWIK 265 >4CZT-A nrPDB Length = 464 Score = 137 bits (345), Expect = 1e-32, Method: Compositional matrix adjust. Identities = 74/252 (29%), Positives = 135/252 (53%), Gaps = 4/252 (1%) Query: 336 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 395 R ++ + LG+G+F KV + + A+K++ K+ V+++ + E + Sbjct: 7 RTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMK 66 Query: 396 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 455 L K P + ++ + ++YFV+E+V GG+L I GR KE A Y ++ + Sbjct: 67 LI-KHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVD 125 Query: 456 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCK--ENIWDGVTTKTFCGTPDYIAPEII 513 + S+G+ +RDLK +N++LD+ G +K++DFG+ + + + T CGTP+Y+APE+I Sbjct: 126 YCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVI 185 Query: 514 AYQPY-GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAIC 572 + Y G D W+ GV+L+ ++AG PFE + L++ I + P S A + Sbjct: 186 NNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLI 245 Query: 573 KGLMTKHPGKRL 584 K ++ +P R+ Sbjct: 246 KRILDPNPATRI 257 >4UZD-A nrPDB Length = 287 Score = 136 bits (342), Expect = 3e-32, Method: Compositional matrix adjust. Identities = 79/245 (32%), Positives = 127/245 (51%), Gaps = 3/245 (1%) Query: 339 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 398 L DF LGKG FG V L+ K + + A+K+L K ++ VE + + + Sbjct: 7 LEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFK-AQLEKAGVEHQLRREVEIQSHL 65 Query: 399 KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQ 458 + P + +L+ F R+Y ++EY G + +Q++ +F E Y E+A L + Sbjct: 66 RHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCH 125 Query: 459 SKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY 518 SK +I+RD+K +N++L S G +KIADFG T T CGT DY+ PE+I + + Sbjct: 126 SKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRT--TLCGTLDYLPPEMIEGRMH 183 Query: 519 GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTK 578 + VD W+ GVL YE L G+ PFE E ++ I +P +++ A + L+ Sbjct: 184 DEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKH 243 Query: 579 HPGKR 583 +P +R Sbjct: 244 NPSQR 248 >2JAM-A nrPDB Length = 304 Score = 135 bits (341), Expect = 4e-32, Method: Compositional matrix adjust. Identities = 83/253 (32%), Positives = 136/253 (53%), Gaps = 15/253 (5%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTM-VEKRVLALPGKP 400 F F+ VLG G+F +V L +++ T +L+A+K +KK +D +E + V K++ K Sbjct: 11 FIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDSSLENEIAVLKKI-----KH 65 Query: 401 PFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSK 460 + L +++ Y VM+ V+GG+L I + G + E A ++ + +L Sbjct: 66 ENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHEN 125 Query: 461 GIIYRDLKLDNVML---DSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQP 517 GI++RDLK +N++ + I I DFG+ K +G+ + T CGTP Y+APE++A +P Sbjct: 126 GIVHRDLKPENLLYLTPEENSKIMITDFGLSKME-QNGIMS-TACGTPGYVAPEVLAQKP 183 Query: 518 YGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPK----SMSKEAVAICK 573 Y K+VD W+ GV+ Y +L G PF E E +LF+ I E + +S+ A Sbjct: 184 YSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAKDFIC 243 Query: 574 GLMTKHPGKRLGC 586 L+ K P +R C Sbjct: 244 HLLEKDPNERYTC 256 >2E73-A nrPDB Length = 77 Score = 135 bits (339), Expect = 7e-32, Method: Compositional matrix adjust. Identities = 59/71 (83%), Positives = 64/71 (90%) Query: 36 NHKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPAS 95 HKFTARFFKQPTFCSHCTDFIWG GKQG QCQVC FVVH+RCHEFVTF CPGA KGP + Sbjct: 7 GHKFTARFFKQPTFCSHCTDFIWGIGKQGLQCQVCSFVVHRRCHEFVTFECPGAGKGPQT 66 Query: 96 DDPRSKHKFKI 106 DDPR+KHKF++ Sbjct: 67 DDPRNKHKFRL 77 Score = 49.7 bits (117), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 19/44 (43%), Positives = 26/44 (59%) Query: 100 SKHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRC 143 S HKF + PTFC HC ++G+ QG++C C VH+RC Sbjct: 6 SGHKFTARFFKQPTFCSHCTDFIWGIGKQGLQCQVCSFVVHRRC 49 >4B8L-A nrPDB Length = 286 Score = 134 bits (337), Expect = 1e-31, Method: Compositional matrix adjust. Identities = 74/251 (29%), Positives = 133/251 (52%), Gaps = 3/251 (1%) Query: 334 RDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRV 393 + + + DF+ LGKG FG V L+ K + A+K+L K ++ + VE + + Sbjct: 9 KRKFTIDDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQ-LEKEGVEHQLRREIE 67 Query: 394 LALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIG 453 + + P + ++++ F R+Y ++E+ G+L +Q+ GRF E + + E+A Sbjct: 68 IQSHLRHPNILRMYNYFHDRKRIYLMLEFAPRGELYKELQKHGRFDEQRSATFMEELADA 127 Query: 454 LFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEII 513 L + + +I+RD+K +N+++ +G +KIADFG + +T CGT DY+ PE+I Sbjct: 128 LHYCHERKVIHRDIKPENLLMGYKGELKIADFGWSVHA--PSLRRRTMCGTLDYLPPEMI 185 Query: 514 AYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICK 573 + + + VD W GVL YE L G PF+ E + I+ ++ +P +S + + Sbjct: 186 EGKTHDEKVDLWCAGVLCYEFLVGMPPFDSPSHTETHRRIVNVDLKFPPFLSDGSKDLIS 245 Query: 574 GLMTKHPGKRL 584 L+ HP +RL Sbjct: 246 KLLRYHPPQRL 256 >2YZA-A nrPDB Length = 276 Score = 134 bits (336), Expect = 2e-31, Method: Compositional matrix adjust. Identities = 88/267 (32%), Positives = 141/267 (52%), Gaps = 8/267 (2%) Query: 336 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 395 R+K+ + LG G+FGKV + E + T AVKIL + + D V E + L Sbjct: 7 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK 66 Query: 396 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 455 L + P + +L+ T + VMEYV+GG+L +I + GR +E A +I + Sbjct: 67 L-FRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVD 125 Query: 456 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAY 515 + +++RDLK +NV+LD+ + KIADFG+ + DG + CG+P+Y APE+I+ Sbjct: 126 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGL-SNMMSDGEFLRDSCGSPNYAAPEVISG 184 Query: 516 QPY-GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKG 574 + Y G VD W+ GV+LY +L G PF+ E LF+ I P+ +++ + Sbjct: 185 RLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMH 244 Query: 575 LMTKHPGKRLGCGPEGERDIKEHAFFR 601 ++ P KR +DI+EH +F+ Sbjct: 245 MLQVDPLKRATI-----KDIREHEWFK 266 >4D28-A nrPDB Length = 446 Score = 131 bits (329), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 78/270 (28%), Positives = 141/270 (52%), Gaps = 9/270 (3%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 407 +G+G+F KV + T + A+KI+ K ++++ V+ E ++ + + P + +L+ Sbjct: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIV-RHPNIVRLY 75 Query: 408 SCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDL 467 + ++Y V+E+V GG+L I GR KE + Y ++ + SKG+ +RDL Sbjct: 76 EVLASKSKIYIVLEFVTGGELFDRIVHKGRLKEDESRKYFQQLVDAVAHCHSKGVYHRDL 135 Query: 468 KLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY-GKSVDWWA 526 K +N++LD+ G++K++DFG+ CGTP+Y+APE+++ Q Y G + D W+ Sbjct: 136 KPENLLLDTNGNLKVSDFGLSALPQEGVELLNDTCGTPNYVAPEVLSGQGYDGSAADIWS 195 Query: 527 FGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGC 586 GV+L+ +LAG PF D L++ I P S E + ++ +P R+ Sbjct: 196 CGVILFVILAGYLPFSETDLPGLYRKINAAEFDCPPWFSAEVKFLIHRILDPNPKTRIQI 255 Query: 587 GPEGERDIKEHAFFR--YIDWEKLERKEIQ 614 + IK+ +FR Y+ E +E+ Sbjct: 256 -----QGIKKDPWFRKNYVPIRAREEEEVN 280 >3UC3-A nrPDB Length = 361 Score = 131 bits (329), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 90/268 (33%), Positives = 134/268 (50%), Gaps = 20/268 (7%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 ++F+ +G G+FG L K T EL AVK +++ I D++V+ ++ R L + P Sbjct: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGAAI-DENVQREIINHRSL----RHP 76 Query: 402 FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKG 461 + + T L +MEY +GG+L I GRF E A F+ ++ G+ + S Sbjct: 77 NIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQ 136 Query: 462 IIYRDLKLDNVMLDSE--GHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY- 518 I +RDLKL+N +LD +KI DFG K ++ K+ GTP YIAPE++ Q Y Sbjct: 137 ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHS-QPKSTVGTPAYIAPEVLLRQEYD 195 Query: 519 GKSVDWWAFGVLLYEMLAGQAPFEGEDE----DELFQSIMEHNVAYPKS--MSKEAVAIC 572 GK D W+ GV LY ML G PFE +E + Q I+ + P +S E + Sbjct: 196 GKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLI 255 Query: 573 KGLMTKHPGKRLGCGPEGERDIKEHAFF 600 + P R+ PE IK H++F Sbjct: 256 SRIFVADPATRISI-PE----IKTHSWF 278 >2HAK-A nrPDB Length = 328 Score = 130 bits (326), Expect = 3e-30, Method: Compositional matrix adjust. Identities = 82/246 (33%), Positives = 131/246 (53%), Gaps = 4/246 (1%) Query: 339 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 398 + ++ +GKG+F KV L+ T AVKI+ K + ++ E R++ + Sbjct: 14 IGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDK-TQLNPTSLQKLFREVRIMKILN 72 Query: 399 KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQ 458 P + +L +T LY VMEY +GG++ ++ GR KE A +I + + Sbjct: 73 HPN-IVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCH 131 Query: 459 SKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY 518 K I++RDLK +N++LD + +IKIADFG E G TFCG+P Y APE+ + Y Sbjct: 132 QKYIVHRDLKAENLLLDGDMNIKIADFGFSNE-FTVGNKLDTFCGSPPYAAPELFQGKKY 190 Query: 519 -GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMT 577 G VD W+ GV+LY +++G PF+G++ EL + ++ P MS + + K L+ Sbjct: 191 DGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLV 250 Query: 578 KHPGKR 583 +P KR Sbjct: 251 LNPIKR 256 >4JXF-A nrPDB Length = 266 Score = 129 bits (325), Expect = 3e-30, Method: Compositional matrix adjust. Identities = 75/249 (30%), Positives = 129/249 (51%), Gaps = 2/249 (0%) Query: 338 KLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALP 397 K+ DF +LGKGSF V +E T A+K++ K + + V+ E ++ Sbjct: 5 KIEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKI-HCQ 63 Query: 398 GKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQ-QVGRFKEPHAVFYAAEIAIGLFF 456 K P + +L++ F+ + +Y V+E + G++ +++ +V F E A + +I G+ + Sbjct: 64 LKHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLY 123 Query: 457 LQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQ 516 L S GI++RDL L N++L +IKIADFG+ + T CGTP+YI+PEI Sbjct: 124 LHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRS 183 Query: 517 PYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLM 576 +G D W+ G + Y +L G+ PF+ + ++ + P +S EA + L+ Sbjct: 184 AHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLL 243 Query: 577 TKHPGKRLG 585 ++P RL Sbjct: 244 RRNPADRLS 252 >4LQP-A nrPDB Length = 508 Score = 129 bits (325), Expect = 3e-30, Method: Compositional matrix adjust. Identities = 103/356 (28%), Positives = 159/356 (44%), Gaps = 72/356 (20%) Query: 341 DFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKP 400 DF+ + V+GKG+FG+V L ++K T ++YA+K L K + + D + E+ VLA Sbjct: 103 DFHTVKVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKDQLAHVKAERDVLA-GSDS 161 Query: 401 PFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSK 460 P++ L+ FQ LY +ME++ GGDLM + + F E FY AE + + + Sbjct: 162 PWVVSLYYSFQDAQYLYLIMEFLPGGDLMTMLIRWQLFTEDVTRFYMAECILAIETIHKL 221 Query: 461 GIIYRDLKLDNVMLDSEGHIKIADFGM--------------------------CKENIWD 494 G I+R +K DN+++D GHIK++DFG+ K ++ Sbjct: 222 GFIHRAIKPDNILIDIRGHIKLSDFGLSTGFHKTHDSNYYKKLLQQDEATNGISKPGTYN 281 Query: 495 GVTTKTFCGTPDYIAPEI-------------------IAYQPYGKSVDWWAFGVLLY--- 532 TT T + I +AY G + D+ A + LY Sbjct: 282 ANTTDTANKRQTMVVDSISLTMSNRQQIQTWRKSRRLMAYSTVG-TPDYIAPEIFLYQGY 340 Query: 533 --------------EMLAGQAPFEGEDEDELFQSIM--EHNVAYPKS--MSKEAVAICKG 574 E L G PF E E ++ IM E + +P +S EA + + Sbjct: 341 GQECDWWSLGAIMYECLIGWPPFCSETPQETYRKIMNFEQTLQFPDDIHISYEAEDLIRR 400 Query: 575 LMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNF 630 L+T H +RLG G +IK H FFR +DW + ++++ PY PK DT F Sbjct: 401 LLT-HADQRLGRHG-GADEIKSHPFFRGVDWNTI--RQVEAPYIPKLSSITDTRFF 452 >3MN3-A nrPDB Length = 271 Score = 129 bits (325), Expect = 4e-30, Method: Compositional matrix adjust. Identities = 84/253 (33%), Positives = 138/253 (54%), Gaps = 12/253 (4%) Query: 339 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDD---DVECTMVEKRVLA 395 + ++ + LG+GSFGKV L+ T + A+KI+ K V+ + D +E + R+L Sbjct: 3 IGNYQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLL- 61 Query: 396 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 455 + P + +L+ ++ D + V+EY G +L +I Q + E A + +I + Sbjct: 62 ---RHPHIIKLYDVIKSKDEIIMVIEYA-GNELFDYIVQRDKMSEQEARRFFQQIISAVE 117 Query: 456 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIW-DGVTTKTFCGTPDYIAPEIIA 514 + I++RDLK +N++LD ++KIADFG+ NI DG KT CG+P+Y APE+I+ Sbjct: 118 YCHRHKIVHRDLKPENLLLDEHLNVKIADFGL--SNIMTDGNFLKTSCGSPNYAAPEVIS 175 Query: 515 YQPY-GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICK 573 + Y G VD W+ GV+LY ML + PF+ E LF++I PK +S A + K Sbjct: 176 GKLYAGPEVDVWSCGVILYVMLCRRLPFDDESIPVLFKNISNGVYTLPKFLSPGAAGLIK 235 Query: 574 GLMTKHPGKRLGC 586 ++ +P R+ Sbjct: 236 RMLIVNPLNRISI 248 >3LM0-A nrPDB Length = 327 Score = 129 bits (324), Expect = 4e-30, Method: Compositional matrix adjust. Identities = 91/294 (30%), Positives = 141/294 (47%), Gaps = 17/294 (5%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 407 LG+G F V K T + YA K LKK QD E + E VL L P + LH Sbjct: 37 LGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEI-LHEIAVLELAKSCPRVINLH 95 Query: 408 SCFQTMDRLYFVMEYVNGGDLMYHI--QQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYR 465 ++ + ++EY GG++ + E + +I G+++L I++ Sbjct: 96 EVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQNNIVHL 155 Query: 466 DLKLDNVMLDS---EGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSV 522 DLK N++L S G IKI DFGM ++ I + GTP+Y+APEI+ Y P + Sbjct: 156 DLKPQNILLSSIYPLGDIKIVDFGMSRK-IGHACELREIMGTPEYLAPEILNYDPITTAT 214 Query: 523 DWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPK----SMSKEAVAICKGLMTK 578 D W G++ Y +L +PF GED E + +I + NV Y + S+S+ A + L+ K Sbjct: 215 DMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFSSVSQLATDFIQSLLVK 274 Query: 579 HPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFDK 632 +P KR P E + H++ + D+E L E + + +D S+ DK Sbjct: 275 NPEKR----PTAEICLS-HSWLQQWDFENLFHPE-ETSSSSQTQDHSVRSSEDK 322 >6C9D-A nrPDB Length = 459 Score = 129 bits (324), Expect = 4e-30, Method: Compositional matrix adjust. Identities = 81/246 (32%), Positives = 130/246 (52%), Gaps = 4/246 (1%) Query: 339 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 398 + ++ +GKG+F KV L+ T AVKI+ K + ++ E R++ + Sbjct: 20 IGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDK-TQLNPTSLQKLFREVRIMKILN 78 Query: 399 KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQ 458 P + +L +T LY VMEY +GG++ ++ GR KE A +I + + Sbjct: 79 HPN-IVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCH 137 Query: 459 SKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY 518 K I++RDLK +N++LD + +IKIADFG E G FCG+P Y APE+ + Y Sbjct: 138 QKYIVHRDLKAENLLLDGDMNIKIADFGFSNE-FTVGNKLDEFCGSPPYAAPELFQGKKY 196 Query: 519 -GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMT 577 G VD W+ GV+LY +++G PF+G++ EL + ++ P MS + + K L+ Sbjct: 197 DGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLV 256 Query: 578 KHPGKR 583 +P KR Sbjct: 257 LNPIKR 262 >4AF3-A nrPDB Length = 292 Score = 128 bits (321), Expect = 8e-30, Method: Compositional matrix adjust. Identities = 79/246 (32%), Positives = 130/246 (52%), Gaps = 3/246 (1%) Query: 339 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 398 + DF LGKG FG V L+ K + + A+K+L K I+ + VE + + + Sbjct: 22 IDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQ-IEKEGVEHQLRREIEIQAHL 80 Query: 399 KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQ 458 P + +L++ F R+Y ++EY G+L +Q+ F E E+A L + Sbjct: 81 HHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCH 140 Query: 459 SKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY 518 K +I+RD+K +N++L +G +KIADFG + KT CGT DY+ PE+I + + Sbjct: 141 GKKVIHRDIKPENLLLGLKGELKIADFGWSVHA--PSLRRKTMCGTLDYLPPEMIEGRMH 198 Query: 519 GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTK 578 + VD W GVL YE+L G PFE +E ++ I++ ++ +P S+ A + L+ Sbjct: 199 NEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPTGAQDLISKLLRH 258 Query: 579 HPGKRL 584 +P +RL Sbjct: 259 NPSERL 264 >2OU7-A nrPDB Length = 335 Score = 127 bits (319), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 72/239 (30%), Positives = 123/239 (51%), Gaps = 7/239 (2%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVE---KRVLALPGKPPFLT 404 LGKG F K T E++A KI+ K ++++ E +E R LA + Sbjct: 49 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLA----HQHVV 104 Query: 405 QLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIY 464 H F+ D ++ V+E L+ ++ EP A +Y +I +G +L +I+ Sbjct: 105 GFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIH 164 Query: 465 RDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDW 524 RDLKL N+ L+ + +KI DFG+ + +DG K CGTP+YIAPE+++ + + VD Sbjct: 165 RDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGHSFEVDV 224 Query: 525 WAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKR 583 W+ G ++Y +L G+ PFE E + I ++ + PK ++ A ++ + ++ P R Sbjct: 225 WSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTAR 283 >4J52-A nrPDB Length = 293 Score = 126 bits (317), Expect = 3e-29, Method: Compositional matrix adjust. Identities = 72/239 (30%), Positives = 123/239 (51%), Gaps = 7/239 (2%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVE---KRVLALPGKPPFLT 404 LGKG F K T E++A KI+ K ++++ E +E R LA + Sbjct: 22 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLA----HQHVV 77 Query: 405 QLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIY 464 H F+ D ++ V+E L+ ++ EP A +Y +I +G +L +I+ Sbjct: 78 GFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIH 137 Query: 465 RDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDW 524 RDLKL N+ L+ + +KI DFG+ + +DG K CGTP+YIAPE+++ + + VD Sbjct: 138 RDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGHSFEVDV 197 Query: 525 WAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKR 583 W+ G ++Y +L G+ PFE E + I ++ + PK ++ A ++ + ++ P R Sbjct: 198 WSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTAR 256 >3KN6-A nrPDB Length = 325 Score = 126 bits (316), Expect = 4e-29, Method: Compositional matrix adjust. Identities = 80/251 (31%), Positives = 125/251 (49%), Gaps = 20/251 (7%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 407 LG+GSF K +++ +AVKI+ K + T E L L P + +LH Sbjct: 19 LGEGSFSICRKCVHKKSNQAFAVKIISKRMEAN------TQKEITALKLCEGHPNIVKLH 72 Query: 408 SCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDL 467 F + VME +NGG+L I++ F E A + ++ + + G+++RDL Sbjct: 73 EVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDL 132 Query: 468 KLDNVMLDSEG---HIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDW 524 K +N++ E IKI DFG + D KT C T Y APE++ Y +S D Sbjct: 133 KPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYDESCDL 192 Query: 525 WAFGVLLYEMLAGQAPFEGEDED-------ELFQSIMEHNVAYP----KSMSKEAVAICK 573 W+ GV+LY ML+GQ PF+ D E+ + I + + ++ K++S+EA + + Sbjct: 193 WSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQ 252 Query: 574 GLMTKHPGKRL 584 GL+T P KRL Sbjct: 253 GLLTVDPNKRL 263 >3UDB-A nrPDB Length = 317 Score = 125 bits (315), Expect = 4e-29, Method: Compositional matrix adjust. Identities = 88/262 (33%), Positives = 132/262 (50%), Gaps = 20/262 (7%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 407 +G G+FG L K +EL AVK +++ I D++V+ ++ R L + P + + Sbjct: 27 IGAGNFGVARLMRDKQANELVAVKYIERGEKI-DENVKREIINHRSL----RHPNIVRFK 81 Query: 408 SCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDL 467 T L VMEY +GG+L I GRF E A F+ ++ G+ + + + +RDL Sbjct: 82 EVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYAHAMQVAHRDL 141 Query: 468 KLDNVMLDSE--GHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY-GKSVDW 524 KL+N +LD +KIADFG K ++ K+ GTP YIAPE++ + Y GK D Sbjct: 142 KLENTLLDGSPAPRLKIADFGYSKASVLHS-QPKSAVGTPAYIAPEVLLKKEYDGKVADV 200 Query: 525 WAFGVLLYEMLAGQAPFEGEDEDELFQSIMEH--NVAYP----KSMSKEAVAICKGLMTK 578 W+ GV LY ML G PFE +E + F+ + NV Y +S E + + Sbjct: 201 WSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVA 260 Query: 579 HPGKRLGCGPEGERDIKEHAFF 600 P KR+ PE I+ H +F Sbjct: 261 DPAKRISI-PE----IRNHEWF 277 >4I6B-A nrPDB Length = 308 Score = 125 bits (313), Expect = 8e-29, Method: Compositional matrix adjust. Identities = 73/257 (28%), Positives = 124/257 (48%), Gaps = 12/257 (4%) Query: 347 VLGKGSFGKVMLSERKGTDELYAVKILKKDVVI---QDDDVECTMVEKRVLALPGKPPFL 403 LGKG F K +++YA KI+ V Q + ++ + R+L + Sbjct: 35 TLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKIDKEIELHRIL----HHKHV 90 Query: 404 TQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGII 463 Q + F+ + +Y ++EY + + + ++ EP +Y +I GL +L + I+ Sbjct: 91 VQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEIL 150 Query: 464 YRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVD 523 +RDLKL N ++ +K+ DFG+ +T CGTP+Y++PE++ Q +G D Sbjct: 151 HRDLKLGNFFINESMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGAESD 210 Query: 524 WWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKR 583 WA G ++Y ML G+ PFE + E ++SI E P S+ A + +++K+P R Sbjct: 211 IWALGCVMYTMLLGRPPFETTNLKETYRSIREARYTMPSSLLAPAKHLIASMLSKNPEDR 270 Query: 584 LGCGPEGERDIKEHAFF 600 DI H FF Sbjct: 271 PSLD-----DIIRHDFF 282 >5WAX-A nrPDB Length = 310 Score = 122 bits (307), Expect = 4e-28, Method: Compositional matrix adjust. Identities = 84/262 (32%), Positives = 131/262 (50%), Gaps = 20/262 (7%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 407 +G G+FG L + +L AVK +++ I D++V+ ++ R L + P + + Sbjct: 19 IGSGNFGVARLMRNRADGQLVAVKYIERGEKI-DENVQREIINHRSL----RHPNIIRFK 73 Query: 408 SCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDL 467 T L VMEY +GG+L I GRF E A F+ ++ G+ + S + +RDL Sbjct: 74 EVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHSMQVCHRDL 133 Query: 468 KLDNVMLD--SEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY-GKSVDW 524 KL+N +LD + +KI DFG K ++ K+ GTP YIAPE++ + Y GK D Sbjct: 134 KLENTLLDGSTAPRLKICDFGYSKSSVLHS-QPKSTVGTPAYIAPEVLLKKEYDGKVADV 192 Query: 525 WAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKS------MSKEAVAICKGLMTK 578 W+ GV LY ML G PFE DE + F+ ++ + S +S E + + Sbjct: 193 WSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRILGVQYSIPDYVHISPECQDLISRIFVA 252 Query: 579 HPGKRLGCGPEGERDIKEHAFF 600 +P R+ PE I+ H +F Sbjct: 253 NPATRITI-PE----IRNHPWF 269 >3DB8-A nrPDB Length = 317 Score = 121 bits (304), Expect = 9e-28, Method: Compositional matrix adjust. Identities = 69/236 (29%), Positives = 121/236 (51%), Gaps = 1/236 (0%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 407 LGKG F K T E++A K++ K ++++ E M + + P + H Sbjct: 50 LGKGGFAKCYEITDMDTKEVFAGKVVPKSMLLKPHQKE-KMSTEIAIHKSLDNPHVVGFH 108 Query: 408 SCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDL 467 F+ D +Y V+E L+ ++ EP A ++ + G+ +L + +I+RDL Sbjct: 109 GFFEDDDFVYVVLEICRRRSLLELHKRRKAVTEPEARYFMRQTIQGVQYLHNNRVIHRDL 168 Query: 468 KLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAF 527 KL N+ L+ + +KI DFG+ + +DG K CGTP+YIAPE++ + + VD W+ Sbjct: 169 KLGNLFLNDDMDVKIGDFGLATKIEFDGERKKDLCGTPNYIAPEVLCKKGHSFEVDIWSL 228 Query: 528 GVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKR 583 G +LY +L G+ PFE E + I ++ + P+ ++ A A+ + ++ P R Sbjct: 229 GCILYTLLVGKPPFETSCLKETYIRIKKNEYSVPRHINPVASALIRRMLHADPTLR 284 >3ZUT-A nrPDB Length = 362 Score = 121 bits (303), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 86/262 (32%), Positives = 131/262 (50%), Gaps = 20/262 (7%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 407 +G G+FG L K ++EL AVK +++ I D++V+ ++ R L + P + + Sbjct: 27 IGSGNFGVARLMRDKQSNELVAVKYIERGEKI-DENVKREIINHRSL----RHPNIVRFK 81 Query: 408 SCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDL 467 T L VMEY +GG+L I GRF E A F+ ++ G+ + + + +RDL Sbjct: 82 EVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDL 141 Query: 468 KLDNVMLDSE--GHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY-GKSVDW 524 KL+N +LD +KI FG K ++ K+ GTP YIAPE++ + Y GK D Sbjct: 142 KLENTLLDGSPAPRLKICAFGYSKSSVLHS-QPKSTVGTPAYIAPEVLLKKEYDGKVADV 200 Query: 525 WAFGVLLYEMLAGQAPFEGEDEDELFQSIMEH--NVAYP----KSMSKEAVAICKGLMTK 578 W+ GV LY ML G PFE +E + F+ + NV Y +S E + + Sbjct: 201 WSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVA 260 Query: 579 HPGKRLGCGPEGERDIKEHAFF 600 P KR+ PE I+ H +F Sbjct: 261 DPAKRISI-PE----IRNHEWF 277 >4B6L-A nrPDB Length = 281 Score = 120 bits (300), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 68/237 (28%), Positives = 112/237 (47%), Gaps = 1/237 (0%) Query: 347 VLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQL 406 +LGKG F + + T YAVK++ + V + E + E L + + + Sbjct: 16 LLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIE-LHRDLQHRHIVRF 74 Query: 407 HSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRD 466 F+ D +Y +E + L + + EP +Y +I GL +L +GI++RD Sbjct: 75 SHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGILHRD 134 Query: 467 LKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWA 526 LKL N + +K+ DFG+ KT CGTP+Y+APE++ Q +G D W+ Sbjct: 135 LKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPEADVWS 194 Query: 527 FGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKR 583 G ++Y +L G PFE D E ++ I + + P S+S A + ++ P R Sbjct: 195 LGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDR 251 >4YNZ-A nrPDB Length = 342 Score = 120 bits (300), Expect = 3e-27, Method: Compositional matrix adjust. Identities = 72/239 (30%), Positives = 126/239 (52%), Gaps = 6/239 (2%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG-KPPFLTQL 406 LGKG G V L T + A+KI+ ++ + + VE+ + L + P + +L Sbjct: 18 LGKGQTGLVKLGIHCVTCQKVAIKIVNREKL---SESVLMKVEREIAILKLIEHPHVLKL 74 Query: 407 HSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRD 466 H ++ LY V+E+V+GG+L ++ + GR A + +I L F S I +RD Sbjct: 75 HDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRD 134 Query: 467 LKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY-GKSVDWW 525 LK +N++LD +I+IADFGM + D + +T CG+P Y PE+I + Y G+ D W Sbjct: 135 LKPENLLLDERNNIRIADFGMASLQVGDSL-LETSCGSPHYACPEVIRGEKYDGRKADVW 193 Query: 526 AFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRL 584 + GV+L+ +L G PF+ ++ +L + + P + + ++ +G++ +RL Sbjct: 194 SCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVDAARRL 252 >2W4O-A nrPDB Length = 349 Score = 119 bits (299), Expect = 3e-27, Method: Compositional matrix adjust. Identities = 95/281 (33%), Positives = 144/281 (51%), Gaps = 19/281 (6%) Query: 314 TKAPEEKTANTISKFDNNG-NRDRMKLTDF-NFLMVLGKGSFGKVMLSERKGTDELYAVK 371 T + TA+ + + +G NRD L+DF LG+G+ V ++KGT + YA+K Sbjct: 27 TASAAPGTASLVPDYWIDGSNRD--ALSDFFEVESELGRGATSIVYRCKQKGTQKPYALK 84 Query: 372 ILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYH 431 +LKK V D + E VL L P + +L F+T + V+E V GG+L Sbjct: 85 VLKKTV-----DKKIVRTEIGVL-LRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDR 138 Query: 432 IQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDS---EGHIKIADFGMC 488 I + G + E A +I + +L GI++RDLK +N++ + + +KIADFG+ Sbjct: 139 IVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLS 198 Query: 489 KENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDE 548 K + V KT CGTP Y APEI+ YG VD W+ G++ Y +L G PF E D+ Sbjct: 199 K-IVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIITYILLCGFEPFYDERGDQ 257 Query: 549 -LFQSIM--EHNVAYP--KSMSKEAVAICKGLMTKHPGKRL 584 +F+ I+ E+ P +S A + + L+ P KRL Sbjct: 258 FMFRRILNCEYYFISPWWDEVSLNAKDLVRKLIVLDPKKRL 298 >2YAB-A nrPDB Length = 361 Score = 119 bits (298), Expect = 4e-27, Method: Compositional matrix adjust. Identities = 77/247 (31%), Positives = 122/247 (49%), Gaps = 11/247 (4%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKP--PFLTQ 405 LG G F V K T YA K +KK C +R +++ + P + Sbjct: 20 LGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIEREVSILRQVLHPNIIT 79 Query: 406 LHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYR 465 LH ++ + ++E V+GG+L + Q E A + +I G+ +L +K I + Sbjct: 80 LHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHTKKIAHF 139 Query: 466 DLKLDNVMLDSEG----HIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKS 521 DLK +N+ML + HIK+ DFG+ E I DGV K GTP+++APEI+ Y+P G Sbjct: 140 DLKPENIMLLDKNIPIPHIKLIDFGLAHE-IEDGVEFKNIFGTPEFVAPEIVNYEPLGLE 198 Query: 522 VDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIM----EHNVAYPKSMSKEAVAICKGLMT 577 D W+ GV+ Y +L+G +PF G+ + E +I + + + S+ A + L+ Sbjct: 199 ADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELAKDFIRKLLV 258 Query: 578 KHPGKRL 584 K KRL Sbjct: 259 KETRKRL 265 >5FG8-A nrPDB Length = 285 Score = 119 bits (298), Expect = 4e-27, Method: Compositional matrix adjust. Identities = 78/244 (31%), Positives = 120/244 (49%), Gaps = 9/244 (3%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 407 LGKG+F V +K T +A KI+ + D + + L P + +LH Sbjct: 22 LGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKL--HHPNIVRLH 79 Query: 408 SCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDL 467 Q + Y V + V GG+L I + E A +I + G+++RDL Sbjct: 80 DSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQNGVVHRDL 139 Query: 468 KLDNVMLDSEGH---IKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDW 524 K +N++L S+ +K+ADFG+ E D F GTP Y++PE++ +PYGKSVD Sbjct: 140 KPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKEPYGKSVDI 199 Query: 525 WAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPK----SMSKEAVAICKGLMTKHP 580 WA GV+LY +L G PF ED+ L+ I YP +++ EA + ++T +P Sbjct: 200 WACGVILYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVNP 259 Query: 581 GKRL 584 KR+ Sbjct: 260 NKRI 263 >2J90-A nrPDB Length = 304 Score = 119 bits (297), Expect = 6e-27, Method: Compositional matrix adjust. Identities = 79/247 (31%), Positives = 124/247 (50%), Gaps = 11/247 (4%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDD-DVECTMVEKRVLALPG-KPPFLTQ 405 LG G F V +KGT + YA K +KK + V +E+ V L + P + Sbjct: 34 LGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILREIRHPNIIT 93 Query: 406 LHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYR 465 LH F+ + ++E V+GG+L + + E A + +I G+ +L SK I + Sbjct: 94 LHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDGVHYLHSKRIAHF 153 Query: 466 DLKLDNVMLDSEG----HIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKS 521 DLK +N+ML + IK+ DFG+ + I G K GTP+++APEI+ Y+P G Sbjct: 154 DLKPENIMLLDKNVPNPRIKLIDFGIAHK-IEAGNEFKNIFGTPEFVAPEIVNYEPLGLE 212 Query: 522 VDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNV----AYPKSMSKEAVAICKGLMT 577 D W+ GV+ Y +L+G +PF GE + E +I N Y + S+ A + L+ Sbjct: 213 ADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYFSNTSELAKDFIRRLLV 272 Query: 578 KHPGKRL 584 K P +R+ Sbjct: 273 KDPKRRM 279 >5XZW-A nrPDB Length = 471 Score = 118 bits (296), Expect = 8e-27, Method: Compositional matrix adjust. Identities = 76/229 (33%), Positives = 121/229 (52%), Gaps = 20/229 (8%) Query: 341 DFNFL-MVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK 399 DF+ + V+G+G+F V + + T + +AVKI+ K VI +++ E VL Sbjct: 196 DFSIIDEVVGQGAFATVKKAIERTTGKTFAVKIISKRKVI--GNMDGVTRELEVLQKLNH 253 Query: 400 PPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQS 459 P + +L ++ + Y VME+V+GGDLM + G E + +I + ++ S Sbjct: 254 PR-IVRLKGFYEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHS 312 Query: 460 KGIIYRDLKLDNVMLDSEG--HIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEII---- 513 GI +RDLK DN++++ + +KI DFG+ K +G KTFCGT Y+APE+I Sbjct: 313 MGISHRDLKPDNILIEQDDPVLVKITDFGLAKVQ-GNGSFMKTFCGTLAYVAPEVIRGKD 371 Query: 514 -AYQP--------YGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSI 553 + P Y VD W+ G L+Y +L G PF G +D+L++ I Sbjct: 372 TSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQI 420 >2VN9-A nrPDB Length = 301 Score = 118 bits (295), Expect = 9e-27, Method: Compositional matrix adjust. Identities = 80/251 (31%), Positives = 122/251 (48%), Gaps = 9/251 (3%) Query: 341 DFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKP 400 ++ LGKG+F V + T + YA KI+ + D + E R+ L K Sbjct: 5 EYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLER-EARICRLL-KH 62 Query: 401 PFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSK 460 P + +LH Y V + V GG+L I + E A +I + Sbjct: 63 PNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLN 122 Query: 461 GIIYRDLKLDNVMLDSE---GHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQP 517 GI++RDLK +N++L S+ +K+ADFG+ E D F GTP Y++PE++ P Sbjct: 123 GIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDP 182 Query: 518 YGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPK----SMSKEAVAICK 573 YGK VD WA GV+LY +L G PF ED+ L+Q I +P +++ EA + Sbjct: 183 YGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLIN 242 Query: 574 GLMTKHPGKRL 584 ++T +P KR+ Sbjct: 243 KMLTINPAKRI 253 >2V7O-A nrPDB Length = 336 Score = 118 bits (295), Expect = 9e-27, Method: Compositional matrix adjust. Identities = 79/251 (31%), Positives = 123/251 (49%), Gaps = 9/251 (3%) Query: 341 DFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKP 400 D+ LGKG+F V +K + YA KI+ + D + E R+ L K Sbjct: 32 DYQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSARDHQKLER-EARICRLL-KH 89 Query: 401 PFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSK 460 P + +LH Y V + V GG+L I + E A +I + + Sbjct: 90 PNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQH 149 Query: 461 GIIYRDLKLDNVMLDSE---GHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQP 517 I++RDLK +N++L S+ +K+ADFG+ E + F GTP Y++PE++ P Sbjct: 150 DIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDP 209 Query: 518 YGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPK----SMSKEAVAICK 573 YGK VD WA GV+LY +L G PF ED+ +L+Q I +P +++ EA + Sbjct: 210 YGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLIN 269 Query: 574 GLMTKHPGKRL 584 ++T +P KR+ Sbjct: 270 QMLTINPAKRI 280 >3H4J-B nrPDB Length = 336 Score = 118 bits (295), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 78/240 (32%), Positives = 129/240 (53%), Gaps = 8/240 (3%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG-KPPFLTQL 406 LG+GSFGKV L+ T + A+K + + ++ + D VE+ + L + P + +L Sbjct: 17 LGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSD--MHMRVEREISYLKLLRHPHIIKL 74 Query: 407 HSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRD 466 + T + V+EY GG+L +I + R E + +I + + I++RD Sbjct: 75 YDVITTPTDIVMVIEYA-GGELFDYIVEKKRMTEDEGRRFFQQIICAIEYCHRHKIVHRD 133 Query: 467 LKLDNVMLDSEGHIKIADFGMCKENIW-DGVTTKTFCGTPDYIAPEIIAYQPY-GKSVDW 524 LK +N++LD ++KIADFG+ NI DG KT CG+P+Y APE+I + Y G VD Sbjct: 134 LKPENLLLDDNLNVKIADFGLS--NIMTDGNFLKTSCGSPNYAAPEVINGKLYAGPEVDV 191 Query: 525 WAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRL 584 W+ G++LY ML G+ PF+ E LF+ + P +S A ++ + ++ P +R+ Sbjct: 192 WSCGIVLYVMLVGRLPFDDEFIPNLFKKVNSCVYVMPDFLSPGAQSLIRRMIVADPMQRI 251 >2BDW-A nrPDB Length = 362 Score = 117 bits (294), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 85/281 (30%), Positives = 132/281 (46%), Gaps = 20/281 (7%) Query: 311 GQGTKAPEEKTANTISKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAV 370 GQ E N +KF +N ++ LGKG+F V K T +A Sbjct: 10 GQQMGRGSEFMMNASTKFSDN----------YDVKEELGKGAFSVVRRCVHKTTGLEFAA 59 Query: 371 KILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMY 430 KI+ + D + E R+ + P + +LH Q Y V + V GG+L Sbjct: 60 KIINTKK-LSARDFQKLEREARI-CRKLQHPNIVRLHDSIQEESFHYLVFDLVTGGELFE 117 Query: 431 HIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGH---IKIADFGM 487 I + E A +I + + S GI++R+LK +N++L S+ +K+ADFG+ Sbjct: 118 DIVAREFYSEADASHCIQQILESIAYCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGL 177 Query: 488 CKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDED 547 E + D F GTP Y++PE++ PY K VD WA GV+LY +L G PF ED+ Sbjct: 178 AIE-VNDSEAWHGFAGTPGYLSPEVLKKDPYSKPVDIWACGVILYILLVGYPPFWDEDQH 236 Query: 548 ELFQSIMEHNVAYPK----SMSKEAVAICKGLMTKHPGKRL 584 L+ I YP +++ EA ++ ++T +P KR+ Sbjct: 237 RLYAQIKAGAYDYPSPEWDTVTPEAKSLIDSMLTVNPKKRI 277 >4MVF-A nrPDB Length = 506 Score = 117 bits (292), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 75/243 (30%), Positives = 132/243 (54%), Gaps = 13/243 (5%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 407 LG+G++G V K T++LYA+K KKD + ++ E ++ P + +L+ Sbjct: 65 LGQGTYGCVYKGIDKVTNQLYAIKEEKKDRL---KNINRFFQEIEIMKKLDHPN-IVKLY 120 Query: 408 SCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDL 467 ++ + +Y +ME +G +L I + G F E +A +I +F+L S I++RDL Sbjct: 121 ETYENDNYIYLIMELCSGRELFDSIIENGSFTEKNAATIMKQIFSAIFYLHSLNIVHRDL 180 Query: 468 KLDNVMLDSEGH---IKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDW 524 K +N + SE +KI DFG+ K N+ G T T GTP Y+AP+++ + Y K D Sbjct: 181 KPENFLFQSENKDSLLKIIDFGLSK-NLGTGEFTTTKAGTPYYVAPQVLDGK-YDKKCDI 238 Query: 525 WAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPK----SMSKEAVAICKGLMTKHP 580 W+ GV++Y +L G PF G+ ++E+ + + + + + S+S +A + L+T +P Sbjct: 239 WSSGVIMYTLLCGYPPFYGDTDNEVLKKVKKGEFCFYENDWGSISSDAKNLITKLLTYNP 298 Query: 581 GKR 583 +R Sbjct: 299 NER 301 >3KK8-A nrPDB Length = 284 Score = 116 bits (291), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 78/244 (31%), Positives = 121/244 (49%), Gaps = 10/244 (4%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 407 LGKG+F V K T +A KI+ + D + E R+ + P + +LH Sbjct: 14 LGKGAFSVVRRCVHKTTGLEFAAKIINTKK-LSARDFQKLEREARI-CRKLQHPNIVRLH 71 Query: 408 SCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDL 467 Q Y V + V GG+L I + E A +I + + S GI++R+L Sbjct: 72 DSIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCHSNGIVHRNL 131 Query: 468 KLDNVMLDSEGH---IKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDW 524 K +N++L S+ +K+ADFG+ E + D F GTP Y++PE++ PY K VD Sbjct: 132 KPENLLLASKAKGAAVKLADFGLAIE-VNDSEAWHGFAGTPGYLSPEVLKKDPYSKPVDI 190 Query: 525 WAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPK----SMSKEAVAICKGLMTKHP 580 WA GV+LY +L G PF ED+ L+ I YP +++ EA ++ ++T +P Sbjct: 191 WACGVILYILLVGYPPFWDEDQHRLYAQIKAGAYDYPSPEWDTVTPEAKSLIDSMLTVNP 250 Query: 581 GKRL 584 KR+ Sbjct: 251 KKRI 254 >5U6Y-A nrPDB Length = 461 Score = 116 bits (291), Expect = 3e-26, Method: Compositional matrix adjust. Identities = 76/244 (31%), Positives = 119/244 (48%), Gaps = 9/244 (3%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 407 LGKG+F V + + YA KI+ + D + E R+ L K P + +LH Sbjct: 8 LGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLER-EARICRLL-KHPNIVRLH 65 Query: 408 SCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDL 467 Y + + V GG+L I + E A +I + G+++RDL Sbjct: 66 DSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDL 125 Query: 468 KLDNVMLDSE---GHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDW 524 K +N++L S+ +K+ADFG+ E + F GTP Y++PE++ PYGK VD Sbjct: 126 KPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDL 185 Query: 525 WAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPK----SMSKEAVAICKGLMTKHP 580 WA GV+LY +L G PF ED+ L+Q I +P +++ EA + ++T +P Sbjct: 186 WACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINP 245 Query: 581 GKRL 584 KR+ Sbjct: 246 SKRI 249 >2VZ6-A nrPDB Length = 313 Score = 115 bits (288), Expect = 6e-26, Method: Compositional matrix adjust. Identities = 76/244 (31%), Positives = 119/244 (48%), Gaps = 9/244 (3%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 407 LGKG+F V + + YA KI+ + D + E R+ L K P + +LH Sbjct: 30 LGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLER-EARICRLL-KHPNIVRLH 87 Query: 408 SCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDL 467 Y + + V GG+L I + E A +I + G+++RDL Sbjct: 88 DSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDL 147 Query: 468 KLDNVMLDSE---GHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDW 524 K +N++L S+ +K+ADFG+ E + F GTP Y++PE++ PYGK VD Sbjct: 148 KPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDL 207 Query: 525 WAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPK----SMSKEAVAICKGLMTKHP 580 WA GV+LY +L G PF ED+ L+Q I +P +++ EA + ++T +P Sbjct: 208 WACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINP 267 Query: 581 GKRL 584 KR+ Sbjct: 268 SKRI 271 >2A27-A nrPDB Length = 321 Score = 115 bits (287), Expect = 9e-26, Method: Compositional matrix adjust. Identities = 78/247 (31%), Positives = 120/247 (48%), Gaps = 11/247 (4%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKK-DVVIQDDDVECTMVEKRVLALPGKPPF-LTQ 405 LG G F V K T YA K +KK V +E+ V L + Sbjct: 20 LGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVLHHNVIT 79 Query: 406 LHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYR 465 LH ++ + ++E V+GG+L + Q E A + +I G+ +L +K I + Sbjct: 80 LHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHTKKIAHF 139 Query: 466 DLKLDNVMLDSEG----HIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKS 521 DLK +N+ML + HIK+ DFG+ E I DGV K GTP+++APEI+ Y+P G Sbjct: 140 DLKPENIMLLDKNIPIPHIKLIDFGLAHE-IEDGVEFKNIFGTPEFVAPEIVNYEPLGLE 198 Query: 522 VDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIM----EHNVAYPKSMSKEAVAICKGLMT 577 D W+ GV+ Y +L+G +PF G+ + E +I + + + S+ A + L+ Sbjct: 199 ADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELAKDFIRKLLV 258 Query: 578 KHPGKRL 584 K KRL Sbjct: 259 KETRKRL 265 >5JN2-A nrPDB Length = 525 Score = 115 bits (287), Expect = 9e-26, Method: Compositional matrix adjust. Identities = 81/269 (30%), Positives = 138/269 (51%), Gaps = 15/269 (5%) Query: 347 VLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQL 406 VLGKGSFG+V+L + K T + AVK++ K V Q D E + E ++L P + +L Sbjct: 74 VLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDHPNIM-KL 132 Query: 407 HSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRD 466 + F+ Y V E GG+L I RF E A ++ G+ ++ I++RD Sbjct: 133 YEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRD 192 Query: 467 LKLDNVMLDS---EGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVD 523 LK +N++L+S + +I+I DFG+ + K GT YIAPE++ + Y + D Sbjct: 193 LKPENLLLESKSKDANIRIIDFGLST-HFEASKKMKDKIGTAYYIAPEVL-HGTYDEKCD 250 Query: 524 WWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYP----KSMSKEAVAICKGLMTKH 579 W+ GV+LY +L+G PF G +E ++ + + + + K +S+ A + + ++T Sbjct: 251 VWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFELPQWKKVSESAKDLIRKMLTYV 310 Query: 580 PGKRLGCGPEGERDIKEHAFFRYIDWEKL 608 P R+ RD +H + + E++ Sbjct: 311 PSMRISA-----RDALDHEWIQTYTKEQI 334 >4CQG-A nrPDB Length = 331 Score = 114 bits (285), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 71/250 (28%), Positives = 125/250 (50%), Gaps = 7/250 (2%) Query: 339 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 398 L + +G G F KV L+ T E+ A+KI+ K+ + D V+ + AL Sbjct: 8 LKYYELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGSD----LPRVKTEIDALKS 63 Query: 399 -KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFL 457 + + QL+ +T ++++ V+EY GG+L +I R E +I + ++ Sbjct: 64 LRHQHICQLYHVLETKNKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQILSAVAYV 123 Query: 458 QSKGIIYRDLKLDNVMLDSEGHIKIADFGMC-KENIWDGVTTKTFCGTPDYIAPEIIAYQ 516 S+G +RDLK +N++ D +K+ DFG+C K + CG+ Y APE+I + Sbjct: 124 HSQGYAHRDLKPENLLFDENHKLKLIDFGLCAKPKGNKDYHLQECCGSLAYAAPELIQGK 183 Query: 517 PY-GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGL 575 Y G D W+ G+LLY ++ G PF+ ++ L++ IM PK +S ++ + + + Sbjct: 184 SYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYEVPKWLSPSSILLLQQM 243 Query: 576 MTKHPGKRLG 585 + P KR+ Sbjct: 244 LQVDPKKRIS 253 >3MA6-A nrPDB Length = 298 Score = 114 bits (285), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 80/262 (30%), Positives = 135/262 (51%), Gaps = 15/262 (5%) Query: 347 VLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQL 406 VLGKGSFG+V+L + K T + AVK++ K V Q D E + E ++L P + +L Sbjct: 39 VLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDHPNIM-KL 97 Query: 407 HSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRD 466 + F+ Y V E GG+L I RF E A ++ G+ ++ I++RD Sbjct: 98 YEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRD 157 Query: 467 LKLDNVMLDS---EGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVD 523 LK +N++L+S + +I+I DFG+ + K GT YIAPE++ + Y + D Sbjct: 158 LKPENLLLESKSKDANIRIIDFGLS-THFEASKKMKDKIGTAYYIAPEVL-HGTYDEKCD 215 Query: 524 WWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYP----KSMSKEAVAICKGLMTKH 579 W+ GV+LY +L+G PF G +E ++ + + + + K +S+ A + + ++T Sbjct: 216 VWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFELPQWKKVSESAKDLIRKMLTYV 275 Query: 580 PGKRLGCGPEGERDIKEHAFFR 601 P R+ RD +H + + Sbjct: 276 PSMRISA-----RDALDHEWIQ 292 >1ZWS-A nrPDB Length = 288 Score = 114 bits (285), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 80/249 (32%), Positives = 121/249 (48%), Gaps = 15/249 (6%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKK-DVVIQDDDVECTMVEKRVLALPGKPPF-LTQ 405 LG G F V K T YA K +KK V +E+ V L + Sbjct: 20 LGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVLHHNVIT 79 Query: 406 LHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYR 465 LH ++ + ++E V+GG+L + Q E A + +I G+ +L +K I + Sbjct: 80 LHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHTKKIAHF 139 Query: 466 DLKLDNVMLDSEG----HIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKS 521 DLK +N+ML + HIK+ DFG+ E I DGV K GTP+++APEI+ Y+P G Sbjct: 140 DLKPENIMLLDKNIPIPHIKLIDFGLAHE-IEDGVEFKNIFGTPEFVAPEIVNYEPLGLE 198 Query: 522 VDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYP------KSMSKEAVAICKGL 575 D W+ GV+ Y +L+G +PF G+ + E +I +V+Y S+ A + L Sbjct: 199 ADMWSIGVITYILLSGASPFLGDTKQETLANIT--SVSYDFDEEFFSHTSELAKDFIRKL 256 Query: 576 MTKHPGKRL 584 + K KRL Sbjct: 257 LVKETRKRL 265 >3NCG-A nrPDB Length = 486 Score = 113 bits (283), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 74/250 (29%), Positives = 129/250 (51%), Gaps = 11/250 (4%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 +N + +LGKGSFG+V+ + + T + YAVK++ K ++ D + E +L P Sbjct: 24 YNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINK-ASAKNKDTSTILREVELLKKLDHPN 82 Query: 402 FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKG 461 + +L + Y V E GG+L I + RF E A ++ G+ ++ Sbjct: 83 IM-KLFEILEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMHKHN 141 Query: 462 IIYRDLKLDNVMLDSEGH---IKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY 518 I++RDLK +N++L+S+ IKI DFG+ K GT YIAPE++ Y Sbjct: 142 IVHRDLKPENILLESKEKDCDIKIIDFGLST-CFQQNTKMKDRIGTAYYIAPEVLR-GTY 199 Query: 519 GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYP----KSMSKEAVAICKG 574 + D W+ GV+LY +L+G PF G++E ++ + + A+ +++S +A + + Sbjct: 200 DEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRVETGKYAFDLPQWRTISDDAKDLIRK 259 Query: 575 LMTKHPGKRL 584 ++T HP R+ Sbjct: 260 MLTFHPSLRI 269 >3HZT-A nrPDB Length = 467 Score = 113 bits (283), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 77/246 (31%), Positives = 124/246 (50%), Gaps = 10/246 (4%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 407 LG G++G+V+L + K T A+KI+KK V + + E VL P + +L+ Sbjct: 12 LGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDHPNIM-KLY 70 Query: 408 SCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDL 467 F+ Y VME GG+L I +F E A ++ G +L I++RDL Sbjct: 71 EFFEDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLSGTTYLHKHNIVHRDL 130 Query: 468 KLDNVMLDSEGH---IKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDW 524 K +N++L+S+ IKI DFG+ + G K GT YIAPE++ + Y + D Sbjct: 131 KPENLLLESKSRDALIKIVDFGLSA-HFEVGGKMKERLGTAYYIAPEVLR-KKYDEKCDV 188 Query: 525 WAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYP----KSMSKEAVAICKGLMTKHP 580 W+ GV+LY +L G PF G+ + E+ + + + ++ +S EA + K ++T P Sbjct: 189 WSCGVILYILLCGYPPFGGQTDQEILKRVEKGKFSFDPPDWTQVSDEAKQLVKLMLTYEP 248 Query: 581 GKRLGC 586 KR+ Sbjct: 249 SKRISA 254 >3DFA-A nrPDB Length = 286 Score = 113 bits (283), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 74/250 (29%), Positives = 129/250 (51%), Gaps = 11/250 (4%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 +N + +LGKGSFG+V+ + + T + YAVK++ K ++ D + E +L P Sbjct: 24 YNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINK-ASAKNKDTSTILREVELLKKLDHPN 82 Query: 402 FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKG 461 + +L + Y V E GG+L I + RF E A ++ G+ ++ Sbjct: 83 IM-KLFEILEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMHKHN 141 Query: 462 IIYRDLKLDNVMLDSEGH---IKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY 518 I++RDLK +N++L+S+ IKI DFG+ K GT YIAPE++ Y Sbjct: 142 IVHRDLKPENILLESKEKDCDIKIIDFGLST-CFQQNTKMKDRIGTAYYIAPEVLR-GTY 199 Query: 519 GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYP----KSMSKEAVAICKG 574 + D W+ GV+LY +L+G PF G++E ++ + + A+ +++S +A + + Sbjct: 200 DEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRVETGKYAFDLPQWRTISDDAKDLIRK 259 Query: 575 LMTKHPGKRL 584 ++T HP R+ Sbjct: 260 MLTFHPSLRI 269 >4PDS-A nrPDB Length = 347 Score = 113 bits (282), Expect = 3e-25, Method: Compositional matrix adjust. Identities = 75/229 (32%), Positives = 119/229 (51%), Gaps = 20/229 (8%) Query: 341 DFNFL-MVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK 399 DF+ + V+G+G+F V + + T + ++VKI+ K VI + D E VL Sbjct: 31 DFSIIDEVVGQGAFATVKKAIERTTGKTFSVKIISKRKVIGNMD--GVTRELEVLQKLNH 88 Query: 400 PPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQS 459 P + +L ++ + Y VME+V+GGDLM + G E + +I + ++ S Sbjct: 89 PR-IVRLKGFYEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHS 147 Query: 460 KGIIYRDLKLDNVMLDSEG--HIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEII---- 513 GI +RDLK DN++++ + +KI FG+ K +G KTFCGT Y+APE+I Sbjct: 148 MGISHRDLKPDNILIEQDDPVLVKITAFGLAKVQ-GNGSFMKTFCGTLAYVAPEVIRGKD 206 Query: 514 -AYQP--------YGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSI 553 + P Y VD W+ G L+Y +L G PF G +D+L++ I Sbjct: 207 TSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQI 255 >3DXN-A nrPDB Length = 287 Score = 113 bits (282), Expect = 3e-25, Method: Compositional matrix adjust. Identities = 77/246 (31%), Positives = 124/246 (50%), Gaps = 10/246 (4%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 407 LG G++G+V+L + K T A+KI+KK V + + E VL P + +L+ Sbjct: 29 LGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDHPNIM-KLY 87 Query: 408 SCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDL 467 F+ Y VME GG+L I +F E A ++ G +L I++RDL Sbjct: 88 EFFEDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLSGTTYLHKHNIVHRDL 147 Query: 468 KLDNVMLDSEGH---IKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDW 524 K +N++L+S+ IKI DFG+ + G K GT YIAPE++ + Y + D Sbjct: 148 KPENLLLESKSRDALIKIVDFGLS-AHFEVGGKMKERLGTAYYIAPEVLR-KKYDEKCDV 205 Query: 525 WAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYP----KSMSKEAVAICKGLMTKHP 580 W+ GV+LY +L G PF G+ + E+ + + + ++ +S EA + K ++T P Sbjct: 206 WSCGVILYILLCGYPPFGGQTDQEILKRVEKGKFSFDPPDWTQVSDEAKQLVKLMLTYEP 265 Query: 581 GKRLGC 586 KR+ Sbjct: 266 SKRISA 271 >3SOA-A nrPDB Length = 444 Score = 112 bits (281), Expect = 4e-25, Method: Compositional matrix adjust. Identities = 74/251 (29%), Positives = 120/251 (47%), Gaps = 9/251 (3%) Query: 341 DFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKP 400 ++ LGKG+F V + + YA I+ + D + E R+ L K Sbjct: 12 EYQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDHQKLER-EARICRLL-KH 69 Query: 401 PFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSK 460 P + +LH Y + + V GG+L I + E A +I + Sbjct: 70 PNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQM 129 Query: 461 GIIYRDLKLDNVMLDSE---GHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQP 517 G+++R+LK +N++L S+ +K+ADFG+ E + F GTP Y++PE++ P Sbjct: 130 GVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDP 189 Query: 518 YGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPK----SMSKEAVAICK 573 YGK VD WA GV+LY +L G PF ED+ L+Q I +P +++ EA + Sbjct: 190 YGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLIN 249 Query: 574 GLMTKHPGKRL 584 ++T +P KR+ Sbjct: 250 KMLTINPSKRI 260 >5IG1-A nrPDB Length = 344 Score = 112 bits (281), Expect = 4e-25, Method: Compositional matrix adjust. Identities = 77/245 (31%), Positives = 119/245 (48%), Gaps = 12/245 (4%) Query: 347 VLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRV-LALPGKPPFLTQ 405 V+GKG+F V K T E+ AVK++ + E +++ + + + + Sbjct: 24 VIGKGAFSTVHRCVNKRTGEVCAVKVIALKSL---RSSEINKIKREIGICSSLQHEHIVS 80 Query: 406 LHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYR 465 + F+ Y V EYV+GG+L I + E A +I L SK II+R Sbjct: 81 MRRAFRDESHFYLVFEYVSGGELFDEIVTRKFYNEKDASACMHQILSALQHCHSKNIIHR 140 Query: 466 DLKLDNVML---DSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSV 522 DLK +N++L D +KI DFG+ + G T F GTP Y++PE+I PY +V Sbjct: 141 DLKPENLLLASKDPNAPVKITDFGLAV-IMEQGPTYFGFAGTPGYLSPEVIRRVPYDTAV 199 Query: 523 DWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPK----SMSKEAVAICKGLMTK 578 D WA GV+LY +L G PF ED +L+ I +P S++ A + K ++ Sbjct: 200 DVWACGVILYILLVGYPPFWEEDHQKLYAQIKNCQYDFPSPEWDSVTTAAKELIKAMLEP 259 Query: 579 HPGKR 583 +P +R Sbjct: 260 NPKRR 264 >3BHH-A nrPDB Length = 295 Score = 112 bits (279), Expect = 6e-25, Method: Compositional matrix adjust. Identities = 76/244 (31%), Positives = 119/244 (48%), Gaps = 9/244 (3%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 407 +GKG+F V + T YA KI+ + D + E R+ L K + +LH Sbjct: 12 IGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLER-EARICRLL-KHSNIVRLH 69 Query: 408 SCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDL 467 Y V + V GG+L I + E A +I + G+++RDL Sbjct: 70 DSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDL 129 Query: 468 KLDNVMLDSE---GHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDW 524 K +N++L S+ +K+ADFG+ E D F GTP Y++PE++ + YGK VD Sbjct: 130 KPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAYGKPVDI 189 Query: 525 WAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPK----SMSKEAVAICKGLMTKHP 580 WA GV+LY +L G PF ED+ +L+Q I +P +++ EA + ++T +P Sbjct: 190 WACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINP 249 Query: 581 GKRL 584 KR+ Sbjct: 250 AKRI 253 >5JZN-A nrPDB Length = 280 Score = 112 bits (279), Expect = 6e-25, Method: Compositional matrix adjust. Identities = 79/226 (34%), Positives = 114/226 (50%), Gaps = 24/226 (10%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKK------DVVIQDDDVECTMVEKRVLALPGKPP 401 +G G+F V + T YA+KI+KK + +IQ++ + +RV K P Sbjct: 27 IGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHMIQNE----VSILRRV-----KHP 77 Query: 402 FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKG 461 + L LY VME V GGDL I ++ E A +A + +L S Sbjct: 78 NIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLYNLASAIKYLHSLN 137 Query: 462 IIYRDLKLDNVML----DSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQP 517 I++RD+K +N+++ D +K+ DFG+ I DG T CGTP Y+APEIIA Sbjct: 138 IVHRDIKPENLLVYEHQDGSKSLKLGDFGLA--TIVDG-PLYTVCGTPTYVAPEIIAETG 194 Query: 518 YGKSVDWWAFGVLLYEMLAGQAPF--EGEDEDELFQSIMEHNVAYP 561 YG VD WA GV+ Y +L G PF G+D++ LF I+ V +P Sbjct: 195 YGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFP 240 >4D2V-A nrPDB Length = 356 Score = 112 bits (279), Expect = 7e-25, Method: Compositional matrix adjust. Identities = 69/241 (28%), Positives = 119/241 (49%), Gaps = 7/241 (2%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG-KPPFLTQL 406 +G G F KV L+ T E+ A+KI+ K+ + D ++ + AL + + QL Sbjct: 37 IGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSD----LPRIKTEIEALKNLRHQHICQL 92 Query: 407 HSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRD 466 + +T ++++ V+EY GG+L +I R E +I + ++ S+G +RD Sbjct: 93 YHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRD 152 Query: 467 LKLDNVMLDSEGHIKIADFGMC-KENIWDGVTTKTFCGTPDYIAPEIIAYQPY-GKSVDW 524 LK +N++ D +K+ DFG+C K + CG Y APE+I + Y G D Sbjct: 153 LKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQACCGALAYAAPELIQGKSYLGSEADV 212 Query: 525 WAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRL 584 W+ G+LLY ++ G PF+ + L IM PK +S ++ + + ++ P KR+ Sbjct: 213 WSMGILLYVLMCGFLPFDDDTAAALVAKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRI 272 Query: 585 G 585 Sbjct: 273 S 273 >4YZB-A nrPDB Length = 491 Score = 111 bits (278), Expect = 8e-25, Method: Compositional matrix adjust. Identities = 81/265 (30%), Positives = 135/265 (50%), Gaps = 15/265 (5%) Query: 347 VLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQL 406 VLGKGSFG+V+L + K T + YAVK++ K V Q D E + E +L P + +L Sbjct: 37 VLGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTDKELLLKEVELLKKLDHPNIM-KL 95 Query: 407 HSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRD 466 + F+ Y V E GG+L I RF E A ++ G+ ++ I++RD Sbjct: 96 YEFFEDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRD 155 Query: 467 LKLDNVMLDS---EGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVD 523 LK +N++L++ + +I+I DFG+ + K GT YIAPE++ + Y + D Sbjct: 156 LKPENLLLENKRKDANIRIIDFGLST-HFESTKKMKDKIGTAYYIAPEVL-HGTYDEKCD 213 Query: 524 WWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYP----KSMSKEAVAICKGLMTKH 579 W+ GV+LY +L+G PF G +E ++ + + + + K +S+ A + + ++ Sbjct: 214 VWSTGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLPQWKKVSEPAKDLIRKMLAYV 273 Query: 580 PGKRLGCGPEGERDIKEHAFFRYID 604 P R+ RD EH + + D Sbjct: 274 PTMRISA-----RDALEHEWLKTTD 293 >4WNO-A nrPDB Length = 287 Score = 111 bits (277), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 73/250 (29%), Positives = 117/250 (46%), Gaps = 28/250 (11%) Query: 311 GQGTKAPEEKTANTISKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDEL-YA 369 G G+ P T+ KF+ F+ ++G G+F V + +L A Sbjct: 1 GGGSMEPGRGGTETVGKFE------------FSRKDLIGHGAFAVVFKGRHRAAHDLEVA 48 Query: 370 VKILKKDVVIQDDDVECTMVEKRVLALPG-KPPFLTQLHSCFQTMDRLYFVMEYVNGGDL 428 VK + K + + T++ K + L K + L+ + + +Y VMEY NGGDL Sbjct: 49 VKCINKKNLAKSQ----TLLGKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDL 104 Query: 429 MYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEG---------H 479 ++ + E + +IA + L SKGII+RDLK N++L + Sbjct: 105 ADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIR 164 Query: 480 IKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQA 539 +KIADFG + + + T CG+P Y+APE+I Q Y D W+ G ++Y+ L G+A Sbjct: 165 VKIADFGFARY-LQSNMMAATLCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKA 223 Query: 540 PFEGEDEDEL 549 PF+ +L Sbjct: 224 PFQASSPQDL 233 >4RGJ-A nrPDB Length = 520 Score = 111 bits (277), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 88/321 (27%), Positives = 153/321 (47%), Gaps = 33/321 (10%) Query: 297 GNEELRQKFERAKIGQGTKAPEEKTANTISKFDNNGNRDRMKLTDFNFLM--------VL 348 GNE R + + + +G K E + F+N+ R M + + N + +L Sbjct: 18 GNE--RHEMKESSVGISKKIVE-------NSFNNSKLRPGMFIQNSNVVFNEQYKGIKIL 68 Query: 349 GKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHS 408 GKGSFG+V+LS K T YA+K++ K V + D E + E +L + + +L+ Sbjct: 69 GKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKESLLREVELLKMLDHINIM-KLYE 127 Query: 409 CFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLK 468 F+ + Y V + GG+L I RF E A +I G+ ++ +++RDLK Sbjct: 128 FFEDNNYYYLVSDVYTGGELFDEIISRKRFYEIDAARIIKQILSGITYMHKNNVVHRDLK 187 Query: 469 LDNVMLDSEGH----IKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDW 524 +N++L+++ IKI DFG+ + K GT YIAP+++ + Y + D Sbjct: 188 PENILLETKNKEDMIIKIIDFGLSTHFEYSK-KMKDKIGTAYYIAPDVL-HGTYDEKCDI 245 Query: 525 WAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYP----KSMSKEAVAICKGLMTKHP 580 W+ GV+LY +L+G PF G +E ++ + + + K +S +A + K ++ Sbjct: 246 WSCGVILYILLSGCPPFNGSNEYDILKKVEAGKYTFDLPQFKKISDKAKDLIKKMLMYTS 305 Query: 581 GKRLGCGPEGERDIKEHAFFR 601 R+ RD EH + + Sbjct: 306 AVRISA-----RDALEHEWIK 321 >4FIE-A nrPDB Length = 423 Score = 109 bits (273), Expect = 4e-24, Method: Compositional matrix adjust. Identities = 73/273 (26%), Positives = 134/273 (49%), Gaps = 38/273 (13%) Query: 343 NFLMVLGKGSFGKVMLSERKGTDELYAVK-----------ILKKDVVIQDDDVECTMVEK 391 NF+ + G+GS G V ++ + + +L AVK +L +VVI D +VE Sbjct: 155 NFIKI-GEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVE- 212 Query: 392 RVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIA 451 +++ + D L+ VME++ GG L + R E + Sbjct: 213 --------------MYNSYLVGDELWVVMEFLEGGALTDIVTHT-RMNEEQIAAVCLAVL 257 Query: 452 IGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPE 511 L L ++G+I+RD+K D+++L +G +K++DFG C + + K+ GTP ++APE Sbjct: 258 QALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE 317 Query: 512 IIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAI 571 +I+ PYG VD W+ G+++ EM+ G+ P+ E + + I ++ K++ K + ++ Sbjct: 318 LISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSL 377 Query: 572 CKG----LMTKHPGKRLGCGPEGERDIKEHAFF 600 KG L+ + P +R ++ +H F Sbjct: 378 -KGFLDRLLVRDPAQRATAA-----ELLKHPFL 404 >2F57-A nrPDB Length = 317 Score = 109 bits (272), Expect = 4e-24, Method: Compositional matrix adjust. Identities = 72/256 (28%), Positives = 128/256 (50%), Gaps = 33/256 (12%) Query: 343 NFLMVLGKGSFGKVMLSERKGTDELYAVK-----------ILKKDVVIQDDDVECTMVEK 391 NF+ + G+GS G V ++ K T + AVK +L +VVI D +V+ Sbjct: 49 NFIKI-GEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVD- 106 Query: 392 RVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIA 451 ++S + D L+ VME++ GG L + R E + Sbjct: 107 --------------MYSSYLVGDELWVVMEFLEGGALTDIVTHT-RMNEEQIATVCLSVL 151 Query: 452 IGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPE 511 L +L ++G+I+RD+K D+++L S+G IK++DFG C + + K+ GTP ++APE Sbjct: 152 RALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPE 211 Query: 512 IIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAI 571 +I+ PYG VD W+ G+++ EM+ G+ P+ E + + I + K + K + ++ Sbjct: 212 VISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVS-SV 270 Query: 572 CKG----LMTKHPGKR 583 +G ++ + P +R Sbjct: 271 LRGFLDLMLVREPSQR 286 >6FDY-U nrPDB Length = 276 Score = 109 bits (272), Expect = 5e-24, Method: Compositional matrix adjust. Identities = 77/255 (30%), Positives = 123/255 (48%), Gaps = 11/255 (4%) Query: 338 KLTDFNFLMVLGKGSFGKVMLS-ERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLAL 396 +L F LG G++ V + +K T E+ A+K + K + VE + E +L Sbjct: 9 RLDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKS-LNKASVENLLTEIEILK- 66 Query: 397 PGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFF 456 + P + QL D +Y +ME+ GGDL I E A + ++A L F Sbjct: 67 GIRHPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQF 126 Query: 457 LQSKGIIYRDLKLDNVMLDS--EGHIKIADFGMCKE-NIWDGVTTKTFCGTPDYIAPEII 513 L + I + DLK N++L S + H+K+ADFG + + WD G+P Y+APE++ Sbjct: 127 LHERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWD--EKHVLRGSPLYMAPEMV 184 Query: 514 AYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVA---YPKSMSKEAVA 570 + Y VD W+ GV+LYE L GQ PF EL + I + V +S++ Sbjct: 185 CQRQYDARVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRPLLSRDCRD 244 Query: 571 ICKGLMTKHPGKRLG 585 + + L+ + P +R+ Sbjct: 245 LLQRLLERDPSRRIS 259 >3GUB-A nrPDB Length = 295 Score = 108 bits (270), Expect = 8e-24, Method: Compositional matrix adjust. Identities = 76/251 (30%), Positives = 117/251 (46%), Gaps = 19/251 (7%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVV------IQDDDVECTMVEKRVLALPGKPP 401 LG G F V K T YA K +KK + +D+E E +L P Sbjct: 19 LGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIER---EVSILKEIQHPN 75 Query: 402 FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKG 461 +T LH ++ + + E V GG+L + + E A + +I G+++L S Sbjct: 76 VIT-LHEVYENKTDVILIGELVAGGELFDFLAEKESLTEEEATEFLKQILNGVYYLHSLQ 134 Query: 462 IIYRDLKLDNVMLDSEG----HIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQP 517 I + DLK +N+ML IKI DFG+ + I G K GTP+++APEI+ Y+P Sbjct: 135 IAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHK-IDFGNEFKNIFGTPEFVAPEIVNYEP 193 Query: 518 YGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKG--- 574 G D W+ GV+ Y +L+G +PF G+ + E ++ N + A+ K Sbjct: 194 LGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFSNTSALAKDFIR 253 Query: 575 -LMTKHPGKRL 584 L+ K P KR+ Sbjct: 254 RLLVKDPKKRM 264 >4JDH-A nrPDB Length = 346 Score = 107 bits (268), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 71/256 (27%), Positives = 129/256 (50%), Gaps = 33/256 (12%) Query: 343 NFLMVLGKGSFGKVMLSERKGTDELYAVK-----------ILKKDVVIQDDDVECTMVEK 391 NF+ + G+GS G V ++ + + +L AVK +L +VVI D +VE Sbjct: 78 NFIKI-GEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVE- 135 Query: 392 RVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIA 451 +++ + D L+ VME++ GG L + R E + Sbjct: 136 --------------MYNSYLVGDELWVVMEFLEGGALTDIVTHT-RMNEEQIAAVCLAVL 180 Query: 452 IGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPE 511 L L ++G+I+RD+K D+++L +G +K++DFG C + + K+ GTP ++APE Sbjct: 181 QALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE 240 Query: 512 IIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAI 571 +I+ PYG VD W+ G+++ EM+ G+ P+ E + + I ++ K++ K + ++ Sbjct: 241 LISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSL 300 Query: 572 CKG----LMTKHPGKR 583 KG L+ + P +R Sbjct: 301 -KGFLDRLLVRDPAQR 315 >5J5T-A nrPDB Length = 370 Score = 107 bits (268), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 79/271 (29%), Positives = 131/271 (48%), Gaps = 25/271 (9%) Query: 341 DFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG-K 399 DF + +G G++G V + T EL A+K++K + + +V++ ++ + K Sbjct: 5 DFELIQRIGSGTYGDVYKARNVNTGELAAIKVIK-----LEPGEDFAVVQQEIIMMKDCK 59 Query: 400 PPFLTQLHSCFQTMDRLYFVMEYVNGGDL--MYHIQQVGRFKEPHAVFYAAEIAIGLFFL 457 P + + D+L+ ME+ GG L +YH+ G E + + E GL++L Sbjct: 60 HPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHV--TGPLSELQIAYVSRETLQGLYYL 117 Query: 458 QSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQ- 516 SKG ++RD+K N++L GH+K+ADFG+ + K F GTP ++APE+ A + Sbjct: 118 HSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKAFIGTPYWMAPEVAAVER 177 Query: 517 --PYGKSVDWWAFGVLLYEMLAGQAP-FEGEDEDELFQSIMEHNVAYPKSMSKEAVA--- 570 Y + D WA G+ E+ Q P F+ LF + + N PK K + Sbjct: 178 KGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFL-MTKSNFQPPKLKDKMKWSNSF 236 Query: 571 --ICKGLMTKHPGKRLGCGPEGERDIKEHAF 599 K +TK+P KR P E+ + +H F Sbjct: 237 HHFVKMALTKNPKKR----PTAEK-LLQHPF 262 >4XBR-A nrPDB Length = 366 Score = 107 bits (267), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 71/256 (27%), Positives = 129/256 (50%), Gaps = 33/256 (12%) Query: 343 NFLMVLGKGSFGKVMLSERKGTDELYAVK-----------ILKKDVVIQDDDVECTMVEK 391 NF+ + G+GS G V ++ + + +L AVK +L +VVI D +VE Sbjct: 98 NFIKI-GEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVE- 155 Query: 392 RVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIA 451 +++ + D L+ VME++ GG L + R E + Sbjct: 156 --------------MYNSYLVGDELWVVMEFLEGGALTDIVTHT-RMNEEQIAAVCLAVL 200 Query: 452 IGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPE 511 L L ++G+I+RD+K D+++L +G +K++DFG C + + K+ GTP ++APE Sbjct: 201 QALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE 260 Query: 512 IIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAI 571 +I+ PYG VD W+ G+++ EM+ G+ P+ E + + I ++ K++ K + ++ Sbjct: 261 LISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSL 320 Query: 572 CKG----LMTKHPGKR 583 KG L+ + P +R Sbjct: 321 -KGFLDRLLVRDPAQR 335 >2Q0N-A nrPDB Length = 301 Score = 107 bits (267), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 71/256 (27%), Positives = 129/256 (50%), Gaps = 33/256 (12%) Query: 343 NFLMVLGKGSFGKVMLSERKGTDELYAVK-----------ILKKDVVIQDDDVECTMVEK 391 NF+ + G+GS G V ++ + + +L AVK +L +VVI D +VE Sbjct: 33 NFIKI-GEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVE- 90 Query: 392 RVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIA 451 +++ + D L+ VME++ GG L + R E + Sbjct: 91 --------------MYNSYLVGDELWVVMEFLEGGALTDIVTHT-RMNEEQIAAVCLAVL 135 Query: 452 IGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPE 511 L L ++G+I+RD+K D+++L +G +K++DFG C + + K+ GTP ++APE Sbjct: 136 QALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE 195 Query: 512 IIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAI 571 +I+ PYG VD W+ G+++ EM+ G+ P+ E + + I ++ K++ K + ++ Sbjct: 196 LISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSL 255 Query: 572 CKG----LMTKHPGKR 583 KG L+ + P +R Sbjct: 256 -KGFLDRLLVRDPAQR 270 >1KOB-A nrPDB Length = 387 Score = 105 bits (261), Expect = 9e-23, Method: Compositional matrix adjust. Identities = 75/267 (28%), Positives = 126/267 (47%), Gaps = 17/267 (6%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 ++ L LG G+FG V K T ++ K + + V+ + L P Sbjct: 53 YDILEELGSGAFGVVHRCVEKATGRVFVAKFINTPYPLDKYTVKNEISIMNQLHHPK--- 109 Query: 402 FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQ-QVGRFKEPHAVFYAAEIAIGLFFLQSK 460 L LH F+ + ++E+++GG+L I + + E + Y + GL + Sbjct: 110 -LINLHDAFEDKYEMVLILEFLSGGELFDRIAAEDYKMSEAEVINYMRQACEGLKHMHEH 168 Query: 461 GIIYRDLKLDNVMLDSE--GHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY 518 I++ D+K +N+M +++ +KI DFG+ + D + K T ++ APEI+ +P Sbjct: 169 SIVHLDIKPENIMCETKKASSVKIIDFGLATKLNPDEIV-KVTTATAEFAAPEIVDREPV 227 Query: 519 GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPK----SMSKEAVAICKG 574 G D WA GVL Y +L+G +PF GED+ E Q++ + + + S+S EA K Sbjct: 228 GFYTDMWAIGVLGYVLLSGLSPFAGEDDLETLQNVKRCDWEFDEDAFSSVSPEAKDFIKN 287 Query: 575 LMTKHPGKRLGCGPEGERDIKEHAFFR 601 L+ K P KRL D EH + + Sbjct: 288 LLQKEPRKRLTV-----HDALEHPWLK 309 >6CMJ-A nrPDB Length = 321 Score = 104 bits (260), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 77/268 (28%), Positives = 127/268 (47%), Gaps = 15/268 (5%) Query: 331 NGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDD------- 383 G +D ++L + +GKGS+G V L+ + + YA+K+L K +I+ Sbjct: 25 TGMQDCVQLDQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGGCIQPRG 84 Query: 384 -VECTMVEKRVLALPGKPPFLTQLHSCFQ-TMDRLYFVMEYVNGGDLMYHIQQVGRFKEP 441 +E E +L P + + D LY V E VN G +M + + E Sbjct: 85 PIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVM-EVPTLKPLSED 143 Query: 442 HAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTF 501 A FY ++ G+ +L + II+RD+K N+++ +GHIKIADFG+ E Sbjct: 144 QARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNT 203 Query: 502 CGTPDYIAPEIIAYQP---YGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNV 558 GTP ++APE ++ GK++D WA GV LY + GQ PF E L I + Sbjct: 204 VGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQAL 263 Query: 559 AYPKS--MSKEAVAICKGLMTKHPGKRL 584 +P ++++ + ++ K+P R+ Sbjct: 264 EFPDQPDIAEDLKDLITRMLDKNPESRI 291 >6E2O-A nrPDB Length = 295 Score = 103 bits (258), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 86/266 (32%), Positives = 128/266 (48%), Gaps = 24/266 (9%) Query: 327 KFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVEC 386 ++D NG+R +VLGKG++G V G D V+I K++ +D Sbjct: 20 EYDENGDR-----------VVLGKGTYGIVY----AGRDLSNQVRIAIKEIPERDSRYSQ 64 Query: 387 TMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQ-QVGRFKEPHAV- 444 + E+ L K + Q F + ME V GG L ++ + G K+ Sbjct: 65 PLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTI 124 Query: 445 -FYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDS-EGHIKIADFGMCKENIWDGVTTKTFC 502 FY +I GL +L I++RD+K DNV++++ G +KI+DFG K T+TF Sbjct: 125 GFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFT 184 Query: 503 GTPDYIAPEIIAYQP--YGKSVDWWAFGVLLYEMLAGQAPFE--GEDEDELFQ-SIMEHN 557 GT Y+APEII P YGK+ D W+ G + EM G+ PF GE + +F+ + + + Sbjct: 185 GTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVH 244 Query: 558 VAYPKSMSKEAVAICKGLMTKHPGKR 583 P+SMS EA A P KR Sbjct: 245 PEIPESMSAEAKAFILKCFEPDPDKR 270 >4NIF-A nrPDB Length = 333 Score = 103 bits (258), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 63/205 (30%), Positives = 103/205 (50%), Gaps = 11/205 (5%) Query: 347 VLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQL 406 +G GS+ + K T+ YAVK++ K +++E +L G+ P + L Sbjct: 15 TIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIE-------ILLRYGQHPNIITL 67 Query: 407 HSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRD 466 + +Y V E + GG+L+ I + F E A F I + +L S+G+++RD Sbjct: 68 KDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRD 127 Query: 467 LKLDNVM-LDSEGH---IKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSV 522 LK N++ +D G+ ++I DFG K+ + T C T +++APE++ Q Y + Sbjct: 128 LKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGC 187 Query: 523 DWWAFGVLLYEMLAGQAPFEGEDED 547 D W+ G+LLY MLAG PF D Sbjct: 188 DIWSLGILLYTMLAGYTPFANGPSD 212 >5YKS-A nrPDB Length = 377 Score = 103 bits (258), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 75/263 (28%), Positives = 128/263 (48%), Gaps = 17/263 (6%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECT---MVEKRVLALPGKPPFLT 404 LG+G F V L+ T E AVK++ K + D T E R + L + P + Sbjct: 43 LGRGHFAVVKLARHVFTGEKVAVKVIDKTKL----DTLATGHLFQEVRCMKLV-QHPNIV 97 Query: 405 QLHSCFQTMDRLYFVMEYVNGGDLM-YHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGII 463 +L+ T +LY ++E +GGD+ Y ++ E A Y A+I + + ++ Sbjct: 98 RLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLHVV 157 Query: 464 YRDLKLDNVML-DSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY-GKS 521 +RDLK +NV+ + +G +K+ DFG + G T CG+ Y APEI+ Y + Sbjct: 158 HRDLKPENVVFFEKQGLVKLTDFGFSNK-FQPGKKLTTSCGSLAYSAPEILLGDEYDAPA 216 Query: 522 VDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPG 581 VD W+ GV+L+ ++ GQ PF+ ++ E IM+ P +SKE + ++ + P Sbjct: 217 VDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITRMLQRDPK 276 Query: 582 KRLGCGPEGERDIKEHAFFRYID 604 +R +I+ H + + +D Sbjct: 277 RRASL-----EEIENHPWLQGVD 294 >2HW6-A nrPDB Length = 307 Score = 103 bits (257), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 87/284 (30%), Positives = 130/284 (45%), Gaps = 41/284 (14%) Query: 335 DRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVL 394 D KLT +LG+G++ KV + + YAVKI++K V E L Sbjct: 12 DMYKLTS----ELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRV---FREVETL 64 Query: 395 ALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGL 454 + +L F+ R Y V E + GG ++ HIQ+ F E A ++A L Sbjct: 65 YQCQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAAL 124 Query: 455 FFLQSKGIIYRDLKLDNVMLDSE---GHIKIADF----GMCKENIWDGVTT---KTFCGT 504 FL +KGI +RDLK +N++ +S +KI DF GM N +TT T CG+ Sbjct: 125 DFLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGS 184 Query: 505 PDYIAPEIIAY-----QPYGKSVDWWAFGVLLYEMLAGQAPFEGE--------------- 544 +Y+APE++ Y K D W+ GV+LY ML+G PF G Sbjct: 185 AEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRV 244 Query: 545 DEDELFQSIMEHNVAYPKS----MSKEAVAICKGLMTKHPGKRL 584 +++LF+SI E +P +S EA + L+ + +RL Sbjct: 245 CQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRL 288 >3LIJ-A nrPDB Length = 494 Score = 103 bits (256), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 75/248 (30%), Positives = 126/248 (50%), Gaps = 15/248 (6%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 407 LG G++G+V+L K T A+KI++K V + + + E VL L P + +L+ Sbjct: 45 LGSGAYGEVLLCRDKVTHVERAIKIIRKTSVSTSSNSKL-LEEVAVLKLLDHPNIM-KLY 102 Query: 408 SCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDL 467 F+ Y VME GG+L I +F E A ++ G+ +L I++RDL Sbjct: 103 DFFEDKRNYYLVMECYKGGELFDEIIHRMKFNEVDAAVIIKQVLSGVTYLHKHNIVHRDL 162 Query: 468 KLDNVMLDS---EGHIKIADFGMCK--ENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSV 522 K +N++L+S + IKI DFG+ EN K GT YIAPE++ + Y + Sbjct: 163 KPENLLLESKEKDALIKIVDFGLSAVFEN---QKKMKERLGTAYYIAPEVLR-KKYDEKC 218 Query: 523 DWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYP----KSMSKEAVAICKGLMTK 578 D W+ GV+L+ +LAG PF G+ + E+ + + + + K++S+ A + K ++ Sbjct: 219 DVWSIGVILFILLAGYPPFGGQTDQEILRKVEKGKYTFDSPEWKNVSEGAKDLIKQMLQF 278 Query: 579 HPGKRLGC 586 +R+ Sbjct: 279 DSQRRISA 286 >6QAU-A nrPDB Length = 280 Score = 102 bits (255), Expect = 4e-22, Method: Compositional matrix adjust. Identities = 66/214 (30%), Positives = 105/214 (49%), Gaps = 16/214 (7%) Query: 347 VLGKGSFGKVMLS-ERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG-KPPFLT 404 ++G G+F V R+ TD A+K + K + + ++ K + L + + Sbjct: 18 LVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQ----ILLGKEIKILKELQHENIV 73 Query: 405 QLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIY 464 L+ + + ++ VMEY NGGDL ++Q G E + +IA + L SKGII+ Sbjct: 74 ALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRILHSKGIIH 133 Query: 465 RDLKLDNVMLD---------SEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAY 515 RDLK N++L S IKIADFG + + + CG+P Y+APE+I Sbjct: 134 RDLKPQNILLSYANRRKSSVSGIRIKIADFGFARY-LHSNMMAADLCGSPMYMAPEVIMS 192 Query: 516 QPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDEL 549 Q Y D W+ G ++Y+ L G+ PF+ +L Sbjct: 193 QHYDAKADLWSIGTVIYQCLVGKPPFQANSPQDL 226 >2XIK-A nrPDB Length = 294 Score = 102 bits (254), Expect = 5e-22, Method: Compositional matrix adjust. Identities = 65/199 (32%), Positives = 106/199 (53%), Gaps = 4/199 (2%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 F L +GKGSFG+V T E+ A+KI+ D+ +D++E E VL+ P Sbjct: 21 FTKLDRIGKGSFGEVYKGIDNHTKEVVAIKII--DLEEAEDEIEDIQQEITVLS-QCDSP 77 Query: 402 FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKG 461 ++T+ + +L+ +MEY+ GG + + + G +E + EI GL +L S+ Sbjct: 78 YITRYFGSYLKSTKLWIIMEYLGGGSAL-DLLKPGPLEETYIATILREILKGLDYLHSER 136 Query: 462 IIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKS 521 I+RD+K NV+L +G +K+ADFG+ + + TF GTP ++APE+I Y Sbjct: 137 KIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFK 196 Query: 522 VDWWAFGVLLYEMLAGQAP 540 D W+ G+ E+ G+ P Sbjct: 197 ADIWSLGITAIELAKGEPP 215 >4QMW-A nrPDB Length = 310 Score = 102 bits (254), Expect = 6e-22, Method: Compositional matrix adjust. Identities = 64/199 (32%), Positives = 104/199 (52%), Gaps = 4/199 (2%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 F L +GKGSFG+V T ++ A+KI+ D+ +D++E E VL+ P Sbjct: 31 FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKII--DLEEAEDEIEDIQQEITVLS-QCDSP 87 Query: 402 FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKG 461 ++T+ + + +L+ +MEY+ GG + + + G E EI GL +L S+ Sbjct: 88 YVTKYYGSYLKDTKLWIIMEYLGGGSAL-DLLEPGPLDETQIATILREILKGLDYLHSEK 146 Query: 462 IIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKS 521 I+RD+K NV+L G +K+ADFG+ + + TF GTP ++APE+I Y Sbjct: 147 KIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSK 206 Query: 522 VDWWAFGVLLYEMLAGQAP 540 D W+ G+ E+ G+ P Sbjct: 207 ADIWSLGITAIELARGEPP 225 >4KS7-A nrPDB Length = 292 Score = 102 bits (253), Expect = 7e-22, Method: Compositional matrix adjust. Identities = 60/205 (29%), Positives = 103/205 (50%), Gaps = 27/205 (13%) Query: 348 LGKGSFGKVMLSERKGTDELYAVK-----------ILKKDVVIQDDDVECTMVEKRVLAL 396 +G+GS G V L+ K + AVK +L +VVI D +VE Sbjct: 31 IGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVE------ 84 Query: 397 PGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFF 456 ++ + + L+ +ME++ GG L + QV R E + L + Sbjct: 85 ---------MYKSYLVGEELWVLMEFLQGGALTDIVSQV-RLNEEQIATVCEAVLQALAY 134 Query: 457 LQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQ 516 L ++G+I+RD+K D+++L +G +K++DFG C + D K+ GTP ++APE+I+ Sbjct: 135 LHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRS 194 Query: 517 PYGKSVDWWAFGVLLYEMLAGQAPF 541 Y VD W+ G+++ EM+ G+ P+ Sbjct: 195 LYATEVDIWSLGIMVIEMVDGEPPY 219 >6HXF-B nrPDB Length = 302 Score = 102 bits (253), Expect = 8e-22, Method: Compositional matrix adjust. Identities = 63/199 (31%), Positives = 107/199 (53%), Gaps = 10/199 (5%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 407 LG G+FGKV ++ K T L A K+++ ++++E +VE +LA P ++ +L Sbjct: 27 LGDGAFGKVYKAKNKETGALAAAKVIETK---SEEELEDYIVEIEILATCDHP-YIVKLL 82 Query: 408 SCFQTMDRLYFVMEYVNGGDLMYHIQQVGR-FKEPHAVFYAAEIAIGLFFLQSKGIIYRD 466 + +L+ ++E+ GG + + ++ R EP ++ L FL SK II+RD Sbjct: 83 GAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKRIIHRD 142 Query: 467 LKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQ-----PYGKS 521 LK NV++ EG I++ADFG+ +N+ +F GTP ++APE++ + PY Sbjct: 143 LKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTPYDYK 202 Query: 522 VDWWAFGVLLYEMLAGQAP 540 D W+ G+ L EM + P Sbjct: 203 ADIWSLGITLIEMAQIEPP 221 >6FD3-A nrPDB Length = 300 Score = 100 bits (248), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 56/198 (28%), Positives = 98/198 (49%), Gaps = 5/198 (2%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 407 +G+G+ G V + T + A+K + +Q + ++ + ++ K P + Sbjct: 30 IGQGASGTVYTALDIATGQEVAIKQMN----LQQQPKKELIINEILVMRENKNPNIVNYL 85 Query: 408 SCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDL 467 + D L+ VMEY+ GG L + + E E L FL S +I+RD+ Sbjct: 86 DSYLVGDELWVVMEYLAGGSLTDVVTETC-MDEGQIAAVCRECLQALDFLHSNQVIHRDI 144 Query: 468 KLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAF 527 K DN++L +G +K+ DFG C + + T GTP ++APE++ + YG VD W+ Sbjct: 145 KSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSL 204 Query: 528 GVLLYEMLAGQAPFEGED 545 G++ EM+ G+ P+ E+ Sbjct: 205 GIMAIEMVEGEPPYLNEN 222 >3Q53-A nrPDB Length = 306 Score = 100 bits (248), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 55/198 (27%), Positives = 98/198 (49%), Gaps = 5/198 (2%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 407 +G+G+ G V + T + A++ + +Q + ++ + ++ K P + Sbjct: 29 IGQGASGTVYTAMDVATGQEVAIRQMN----LQQQPKKELIINEILVMRENKNPNIVNYL 84 Query: 408 SCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDL 467 + D L+ VMEY+ GG L + + E E L FL S +I+RD+ Sbjct: 85 DSYLVGDELWVVMEYLAGGSLTDVVTETC-MDEGQIAAVCRECLQALEFLHSNQVIHRDI 143 Query: 468 KLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAF 527 K DN++L +G +K+ DFG C + + T GTP ++APE++ + YG VD W+ Sbjct: 144 KSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSL 203 Query: 528 GVLLYEMLAGQAPFEGED 545 G++ EM+ G+ P+ E+ Sbjct: 204 GIMAIEMIEGEPPYLNEN 221 >2Y7J-A nrPDB Length = 365 Score = 99.0 bits (245), Expect = 5e-21, Method: Compositional matrix adjust. Identities = 72/269 (26%), Positives = 124/269 (46%), Gaps = 21/269 (7%) Query: 347 VLGKGSFGKVMLSERKGTDELYAVKILKKDVVI----QDDDV-ECTMVEKRVLALPGKPP 401 V+G+G V + T +AVKI++ Q ++V E T E +L P Sbjct: 101 VIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHILRQVAGHP 160 Query: 402 FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKG 461 + L +++ ++ V + + G+L ++ + E + + FL + Sbjct: 161 HIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLEAVSFLHANN 220 Query: 462 IIYRDLKLDNVMLDSEGHIKIADFGM-CKENIWDGVTTKTFCGTPDYIAPEII------A 514 I++RDLK +N++LD I+++DFG C ++ G + CGTP Y+APEI+ Sbjct: 221 IVHRDLKPENILLDDNMQIRLSDFGFSC--HLEPGEKLRELCGTPGYLAPEILKCSMDET 278 Query: 515 YQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKG 574 + YGK VD WA GV+L+ +LAG PF + + + IME + + + K Sbjct: 279 HPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFSSPEWDDRSSTVKD 338 Query: 575 LMTKHPGKRLGCGPEGERDIK---EHAFF 600 L++ + L PE + +H FF Sbjct: 339 LIS----RLLQVDPEARLTAEQALQHPFF 363 >1KOA-A nrPDB Length = 491 Score = 99.0 bits (245), Expect = 6e-21, Method: Compositional matrix adjust. Identities = 59/218 (27%), Positives = 111/218 (50%), Gaps = 8/218 (3%) Query: 339 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 398 L ++ LG G+FG V + T +A K + + + D E E + +++ Sbjct: 50 LDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFV---MTPHESDKETVRKEIQTMSVL- 105 Query: 399 KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHI-QQVGRFKEPHAVFYAAEIAIGLFFL 457 + P L LH F+ + + + E+++GG+L + + + E AV Y ++ GL + Sbjct: 106 RHPTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMRQVCKGLCHM 165 Query: 458 QSKGIIYRDLKLDNVMLDSE--GHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAY 515 ++ DLK +N+M ++ +K+ DFG+ ++ + K GT ++ APE+ Sbjct: 166 HENNYVHLDLKPENIMFTTKRSNELKLIDFGLTA-HLDPKQSVKVTTGTAEFAAPEVAEG 224 Query: 516 QPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSI 553 +P G D W+ GVL Y +L+G +PF GE++DE +++ Sbjct: 225 KPVGYYTDMWSVGVLSYILLSGLSPFGGENDDETLRNV 262 >4FZF-B nrPDB Length = 283 Score = 99.0 bits (245), Expect = 6e-21, Method: Compositional matrix adjust. Identities = 63/199 (31%), Positives = 104/199 (52%), Gaps = 4/199 (2%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 F L +GKGSFG+V T ++ A+KI+ D+ +D++E E VL+ Sbjct: 10 FTKLERIGKGSFGEVFKGIDNRTQQVVAIKII--DLEEAEDEIEDIQQEITVLS-QCDSS 66 Query: 402 FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKG 461 ++T+ + + +L+ +MEY+ GG + + + G F E EI GL +L S+ Sbjct: 67 YVTKYYGSYLKGSKLWIIMEYLGGGSAL-DLLRAGPFDEFQIATMLKEILKGLDYLHSEK 125 Query: 462 IIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKS 521 I+RD+K NV+L +G +K+A FG+ + + TF GTP ++APE+I Y Sbjct: 126 KIHRDIKAANVLLSEQGDVKLAAFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSK 185 Query: 522 VDWWAFGVLLYEMLAGQAP 540 D W+ G+ E+ G+ P Sbjct: 186 ADIWSLGITAIELAKGEPP 204 >4APC-A nrPDB Length = 350 Score = 98.6 bits (244), Expect = 7e-21, Method: Compositional matrix adjust. Identities = 64/212 (30%), Positives = 102/212 (48%), Gaps = 4/212 (1%) Query: 345 LMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLT 404 L +G+GSFGK +L + Y +K + + + E + E VLA K P + Sbjct: 29 LQKIGEGSFGKAILVKSTEDGRQYVIKEINISR-MSSKEREESRREVAVLA-NMKHPNIV 86 Query: 405 QLHSCFQTMDRLYFVMEYVNGGDLMYHI--QQVGRFKEPHAVFYAAEIAIGLFFLQSKGI 462 Q F+ LY VM+Y GGDL I Q+ F+E + + +I + L + + I Sbjct: 87 QYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVHDRKI 146 Query: 463 IYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSV 522 ++RD+K N+ L +G +++ DFG+ + + GTP Y++PEI +PY Sbjct: 147 LHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARACIGTPYYLSPEICENKPYNNKS 206 Query: 523 DWWAFGVLLYEMLAGQAPFEGEDEDELFQSIM 554 D WA G +LYE+ + FE L I+ Sbjct: 207 DIWALGCVLYELCTLKHAFEAGSMKNLVLKII 238 >3PPZ-A nrPDB Length = 309 Score = 98.6 bits (244), Expect = 7e-21, Method: Compositional matrix adjust. Identities = 69/252 (27%), Positives = 128/252 (50%), Gaps = 15/252 (5%) Query: 341 DFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK- 399 D N +G GSFG V +E G+D AVKIL + QD E R +A+ + Sbjct: 38 DLNIKEKIGAGSFGTVHRAEWHGSD--VAVKILME----QDFHAERVNEFLREVAIMKRL 91 Query: 400 -PPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVG---RFKEPHAVFYAAEIAIGLF 455 P + L V EY++ G L + + G + E + A ++A G+ Sbjct: 92 RHPNIVLFMGAVTQPPNLSIVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAKGMN 151 Query: 456 FLQSKG--IIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEII 513 +L ++ I++RDLK N+++D + +K+ DFG+ + +++K+ GTP+++APE++ Sbjct: 152 YLHNRNPPIVHRDLKSPNLLVDKKYTVKVCDFGLSRLKASTFLSSKSAAGTPEWMAPEVL 211 Query: 514 AYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSI--MEHNVAYPKSMSKEAVAI 571 +P + D ++FGV+L+E+ Q P+ + ++ ++ + P++++ + AI Sbjct: 212 RDEPSNEKSDVYSFGVILWELATLQQPWGNLNPAQVVAAVGFKCKRLEIPRNLNPQVAAI 271 Query: 572 CKGLMTKHPGKR 583 +G T P KR Sbjct: 272 IEGCWTNEPWKR 283 >3UTO-A nrPDB Length = 573 Score = 98.6 bits (244), Expect = 8e-21, Method: Compositional matrix adjust. Identities = 59/218 (27%), Positives = 111/218 (50%), Gaps = 8/218 (3%) Query: 339 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 398 L ++ LG G+FG V + T +A K + + + D E E + +++ Sbjct: 156 LDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFV---MTPHESDKETVRKEIQTMSVL- 211 Query: 399 KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHI-QQVGRFKEPHAVFYAAEIAIGLFFL 457 + P L LH F+ + + + E+++GG+L + + + E AV Y ++ GL + Sbjct: 212 RHPTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMRQVCKGLCHM 271 Query: 458 QSKGIIYRDLKLDNVMLDSE--GHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAY 515 ++ DLK +N+M ++ +K+ DFG+ ++ + K GT ++ APE+ Sbjct: 272 HENNYVHLDLKPENIMFTTKRSNELKLIDFGLTA-HLDPKQSVKVTTGTAEFAAPEVAEG 330 Query: 516 QPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSI 553 +P G D W+ GVL Y +L+G +PF GE++DE +++ Sbjct: 331 KPVGYYTDMWSVGVLSYILLSGLSPFGGENDDETLRNV 368 >3Q5I-A nrPDB Length = 504 Score = 98.2 bits (243), Expect = 9e-21, Method: Compositional matrix adjust. Identities = 75/270 (27%), Positives = 131/270 (48%), Gaps = 23/270 (8%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVV----IQDDDVECTMVEKRV-----LALPG 398 LG G++G+V+L + K A+K++KK DD+ + + L Sbjct: 44 LGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYSDDNKNIEKFHEEIYNEISLLKSL 103 Query: 399 KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQ 458 P + +L F+ Y V E+ GG+L I +F E A +I G+ +L Sbjct: 104 DHPNIIKLFDVFEDKKYFYLVTEFYEGGELFEQIINRHKFDECDAANIMKQILSGICYLH 163 Query: 459 SKGIIYRDLKLDNVMLDSEG---HIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAY 515 I++RD+K +N++L+++ +IKI DFG+ D + GT YIAPE++ Sbjct: 164 KHNIVHRDIKPENILLENKNSLLNIKIVDFGLSSFFSKD-YKLRDRLGTAYYIAPEVLK- 221 Query: 516 QPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYP----KSMSKEAVAI 571 + Y + D W+ GV++Y +L G PF G+++ ++ + + + + K++S EA + Sbjct: 222 KKYNEKCDVWSCGVIMYILLCGYPPFGGQNDQDIIKKVEKGKYYFDFNDWKNISDEAKEL 281 Query: 572 CKGLMTKHPGKRLGCGPE---GERDIKEHA 598 K ++T KR C E R IK++A Sbjct: 282 IKLMLTYDYNKR--CTAEEALNSRWIKKYA 309 >3F3Z-A nrPDB Length = 277 Score = 98.2 bits (243), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 68/245 (27%), Positives = 123/245 (50%), Gaps = 13/245 (5%) Query: 347 VLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQL 406 +G+GS+G+V ++ +KGT A K + K V +DV+ E ++ P + +L Sbjct: 16 TIGRGSWGEVKIAVQKGTRIRRAAKKIPKYFV---EDVDRFKQEIEIMKSLDHPNII-RL 71 Query: 407 HSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRD 466 + F+ +Y VME GG+L + F+E A ++ + + + +RD Sbjct: 72 YETFEDNTDIYLVMELCTGGELFERVVHKRVFRESDAARIMKDVLSAVAYCHKLNVAHRD 131 Query: 467 LKLDNVML--DS-EGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVD 523 LK +N + DS + +K+ DFG+ G +T GTP Y++P+++ YG D Sbjct: 132 LKPENFLFLTDSPDSPLKLIDFGLAA-RFKPGKMMRTKVGTPYYVSPQVLE-GLYGPECD 189 Query: 524 WWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPK----SMSKEAVAICKGLMTKH 579 W+ GV++Y +L G PF + E+ I E +P+ ++S +A ++ + L+TK Sbjct: 190 EWSAGVMMYVLLCGYPPFSAPTDSEVMLKIREGTFTFPEKDWLNVSPQAESLIRRLLTKS 249 Query: 580 PGKRL 584 P +R+ Sbjct: 250 PKQRI 254 >2YCR-A nrPDB Length = 323 Score = 97.1 bits (240), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 67/204 (32%), Positives = 104/204 (50%), Gaps = 12/204 (5%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVEC---TMVEKRVLALPG-KPPFL 403 LG G+ G+V L+ + T + A+KI+ K E VE + L P + Sbjct: 18 LGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCI 77 Query: 404 TQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGII 463 ++ + F D Y V+E + GG+L + R KE Y ++ + + +L GII Sbjct: 78 IKIKNFFDAED-YYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGII 136 Query: 464 YRDLKLDNVMLDSEGH---IKIADFGMCKENIWDGVTTKTFCGTPDYIAPEI---IAYQP 517 +RDLK +NV+L S+ IKI DFG K + + +T CGTP Y+APE+ + Sbjct: 137 HRDLKPENVLLSSQEEDCLIKITDFGHSK-ILGETSLMRTLCGTPTYLAPEVLVSVGTAG 195 Query: 518 YGKSVDWWAFGVLLYEMLAGQAPF 541 Y ++VD W+ GV+L+ L+G PF Sbjct: 196 YNRAVDCWSLGVILFICLSGYPPF 219 >5YV8-A nrPDB Length = 298 Score = 97.1 bits (240), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 76/279 (27%), Positives = 125/279 (44%), Gaps = 30/279 (10%) Query: 335 DRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDD----------- 383 D ++L + +GKGS+G V L+ + + YA+K+L K +I+ Sbjct: 8 DCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTR 67 Query: 384 ------------VECTMVEKRVLALPGKPPFLTQLHSCFQ-TMDRLYFVMEYVNGGDLMY 430 +E E +L P + + D LY V E VN G +M Sbjct: 68 PAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVM- 126 Query: 431 HIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKE 490 + + E A FY ++ G+ +L + II+RD+K N+++ +GHIKIADFG+ E Sbjct: 127 EVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNE 186 Query: 491 NIWDGVTTKTFCGTPDYIAPEIIAYQP---YGKSVDWWAFGVLLYEMLAGQAPFEGEDED 547 GTP ++APE ++ GK++D WA GV LY + GQ PF E Sbjct: 187 FKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIM 246 Query: 548 ELFQSIMEHNVAYPKS--MSKEAVAICKGLMTKHPGKRL 584 L I + +P ++++ + ++ K+P R+ Sbjct: 247 CLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRI 285 >4JG6-A nrPDB Length = 355 Score = 97.1 bits (240), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 76/264 (28%), Positives = 125/264 (47%), Gaps = 19/264 (7%) Query: 333 NRDRMKLTD-FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEK 391 +R+ ++ TD + +G GS+ K T+ +AVKI+ K + D E E Sbjct: 27 HRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKS---KRDPTE----EI 79 Query: 392 RVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIA 451 +L G+ P + L + +Y V E + GG+L+ I + F E A I Sbjct: 80 EILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTIT 139 Query: 452 IGLFFLQSKGIIYRDLKLDNVM-LDSEGH---IKIADFGMCKENIWDGVTTKTFCGTPDY 507 + +L ++G+++RDLK N++ +D G+ I+I DFG K+ + T C T ++ Sbjct: 140 KTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANF 199 Query: 508 IAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDED---ELFQSI----MEHNVAY 560 +APE++ Q Y + D W+ GVLLY ML G PF +D E+ I + Y Sbjct: 200 VAPEVLERQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGY 259 Query: 561 PKSMSKEAVAICKGLMTKHPGKRL 584 S+S A + ++ P +RL Sbjct: 260 WNSVSDTAKDLVSKMLHVDPHQRL 283 >2BRG-A nrPDB Length = 297 Score = 96.7 bits (239), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 66/254 (25%), Positives = 133/254 (52%), Gaps = 13/254 (5%) Query: 339 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILK-KDVVIQDDDVECTMVEKRVLALP 397 + D++ + LG+G++G+V L+ + T+E AVKI+ K V ++++ + ++L Sbjct: 6 VEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHE 65 Query: 398 GKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFL 457 + + + + + Y +EY +GG+L I+ EP A + ++ G+ +L Sbjct: 66 N----VVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYL 121 Query: 458 QSKGIIYRDLKLDNVMLDSEGHIKIADFGMC---KENIWDGVTTKTFCGTPDYIAPEIIA 514 GI +RD+K +N++LD ++KI+DFG+ + N + + K CGT Y+APE++ Sbjct: 122 HGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNK-MCGTLPYVAPELLK 180 Query: 515 YQPY-GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYP---KSMSKEAVA 570 + + + VD W+ G++L MLAG+ P++ + S + Y K + +A Sbjct: 181 RREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLA 240 Query: 571 ICKGLMTKHPGKRL 584 + ++ ++P R+ Sbjct: 241 LLHKILVENPSARI 254 >3I6U-A nrPDB Length = 419 Score = 96.3 bits (238), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 84/311 (27%), Positives = 141/311 (45%), Gaps = 22/311 (7%) Query: 294 GSEGNEELRQKFERAKIGQGTKAPEEKTANTISKF-----DNNGNRDRMKLTDFNFLMVL 348 G+ N EL K +R + ++ + N + F D+ + ++ L Sbjct: 84 GTFVNTELVGKGKRRPLNNNSEIALSLSRNKVFVFFDLTVDDQSVYPKALRDEYIMSKTL 143 Query: 349 GKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVEC---TMVEKRVLALPG-KPPFLT 404 G G+ G+V L+ + T + A++I+ K E VE + L P + Sbjct: 144 GSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSAREADPALNVETEIEILKKLNHPCII 203 Query: 405 QLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIY 464 ++ + F D Y V+E + GG+L + R KE Y ++ + + +L GII+ Sbjct: 204 KIKNFFDAED-YYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIH 262 Query: 465 RDLKLDNVMLDSEGH---IKIADFGMCKENIWDGVTTKTFCGTPDYIAPEI---IAYQPY 518 RDLK +NV+L S+ IKI DFG K + + +T CGTP Y+APE+ + Y Sbjct: 263 RDLKPENVLLSSQEEDCLIKITDFGHSK-ILGETSLMRTLCGTPTYLAPEVLVSVGTAGY 321 Query: 519 GKSVDWWAFGVLLYEMLAGQAPF-EGEDEDELFQSIMEHNVAYP----KSMSKEAVAICK 573 ++VD W+ GV+L+ L+G PF E + L I + +S++A+ + K Sbjct: 322 NRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVK 381 Query: 574 GLMTKHPGKRL 584 L+ P R Sbjct: 382 KLLVVDPKARF 392 >3TAC-A nrPDB Length = 361 Score = 95.1 bits (235), Expect = 9e-20, Method: Compositional matrix adjust. Identities = 69/250 (27%), Positives = 121/250 (48%), Gaps = 13/250 (5%) Query: 347 VLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRV-LALPGKPPFLTQ 405 V+GKG F V + T + +AVKI+ + +++ + K P + + Sbjct: 33 VIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKHPHIVE 92 Query: 406 LHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR----FKEPHAVFYAAEIAIGLFFLQSKG 461 L + + LY V E+++G DL + I + + E A Y +I L + Sbjct: 93 LLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRYCHDNN 152 Query: 462 IIYRDLKLDNVMLDSEGH---IKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY 518 II+RD+K V+L S+ + +K+ FG+ + G+ GTP ++APE++ +PY Sbjct: 153 IIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFMAPEVVKREPY 212 Query: 519 GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIM----EHNVAYPKSMSKEAVAICKG 574 GK VD W GV+L+ +L+G PF G E LF+ I+ + N +S+ A + + Sbjct: 213 GKPVDVWGCGVILFILLSGCLPFYGTKE-RLFEGIIKGKYKMNPRQWSHISESAKDLVRR 271 Query: 575 LMTKHPGKRL 584 ++ P +R+ Sbjct: 272 MLMLDPAERI 281 >4CSV-A nrPDB Length = 275 Score = 95.1 bits (235), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 66/241 (27%), Positives = 119/241 (49%), Gaps = 10/241 (4%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 407 LG G FG+V + + + AVK LK+ + ++ ++ + K++ K P L QL+ Sbjct: 19 LGSGQFGEVYEGKWRNYNIEVAVKTLKEGTMSVEEFLQEAQIMKKL-----KHPNLVQLY 73 Query: 408 SCFQTMDRLYFVMEYVNGGDLMYHIQQV-GRFKEPHAVF-YAAEIAIGLFFLQSKGIIYR 465 +Y + EY++ G L+ +++ G A+ AA++A G+ +L+S+ I+R Sbjct: 74 GVCTKEPPIYIITEYMSHGSLLDYLRDCEGHTVNAQALLDMAAQVASGMAYLESQNFIHR 133 Query: 466 DLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTP-DYIAPEIIAYQPYGKSVDW 524 DL N ++ +K+ADFG+ + D T + P + APE I+Y + D Sbjct: 134 DLAARNCLVGENNVVKVADFGLARLINEDEYTARAGAKFPIKWTAPEAISYNRFSIKSDV 193 Query: 525 WAFGVLLYEMLA-GQAPFEGEDEDELFQSIME-HNVAYPKSMSKEAVAICKGLMTKHPGK 582 WAFG+LL+E+ GQ P+ G E+ + + + + P+ +E + K P + Sbjct: 194 WAFGILLWEIFTYGQVPYPGMSGSEVIEQVERGYRMPRPQGCPEEIYELMLQCWNKSPEE 253 Query: 583 R 583 R Sbjct: 254 R 254 >4UYA-A nrPDB Length = 340 Score = 94.7 bits (234), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 68/213 (31%), Positives = 105/213 (49%), Gaps = 22/213 (10%) Query: 347 VLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMV--EKRVLALPGKPPFLT 404 ++G G FG+V + +G + AVK ++D QD V E R+ A+ P + Sbjct: 33 LIGAGGFGQVYRATWQGQE--VAVKAARQDPE-QDAAAAAESVRREARLFAMLRHPNIIE 89 Query: 405 QLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHA-VFYAAEIAIGLFFLQSKG-- 461 C Q L V+E+ GG L + GR PH V +A +IA G+ +L + Sbjct: 90 LRGVCLQQ-PHLCLVLEFARGGALNRAL--AGRRIPPHVLVNWAVQIARGMLYLHEEAFV 146 Query: 462 -IIYRDLKLDNVMLDSE--------GHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEI 512 I++RDLK N++L + +KI DFG+ +E W T G ++APE+ Sbjct: 147 PILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLARE--WHRTTKMATAGAYAWMAPEV 204 Query: 513 IAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGED 545 I + K D W++GVLL+E+L G+ P+ G D Sbjct: 205 IKSSLFSKGSDIWSYGVLLWELLTGEVPYRGID 237 >4XEY-B nrPDB Length = 408 Score = 94.7 bits (234), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 67/233 (28%), Positives = 115/233 (49%), Gaps = 11/233 (4%) Query: 324 TISKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDD 383 T+ N ++ M+ TD LG G +G+V K AVK LK+D + ++ Sbjct: 109 TVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEF 168 Query: 384 VECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHA 443 ++ V K + K P L QL Y + E++ G+L+ ++++ R +E +A Sbjct: 169 LKEAAVMKEI-----KHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNR-QEVNA 222 Query: 444 V---FYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKT 500 V + A +I+ + +L+ K I+RDL N ++ +K+ADFG+ + D T Sbjct: 223 VVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHA 282 Query: 501 FCGTP-DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQ 551 P + APE +AY + D WAFGVLL+E+ G +P+ G D ++++ Sbjct: 283 GAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYE 335 >3DLS-A nrPDB Length = 335 Score = 94.7 bits (234), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 72/242 (29%), Positives = 125/242 (51%), Gaps = 13/242 (5%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALP----GKPPFL 403 LG G+FG V + K ++ VK +KK+ V++D +E + K L + + + Sbjct: 32 LGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANI 91 Query: 404 TQLHSCFQTMDRLYFVME-YVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGI 462 ++ F+ VME + +G DL I + R EP A + ++ + +L+ K I Sbjct: 92 IKVLDIFENQGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASYIFRQLVSAVGYLRLKDI 151 Query: 463 IYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY-GKS 521 I+RD+K +N+++ + IK+ DFG + G TFCGT +Y APE++ PY G Sbjct: 152 IHRDIKDENIVIAEDFTIKLIDFGSAA-YLERGKLFYTFCGTIEYCAPEVLMGNPYRGPE 210 Query: 522 VDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPG 581 ++ W+ GV LY ++ + PF EL +++ E + P +SKE +++ GL+ P Sbjct: 211 LEMWSLGVTLYTLVFEENPF-----CELEETV-EAAIHPPYLVSKELMSLVSGLLQPVPE 264 Query: 582 KR 583 +R Sbjct: 265 RR 266 >6CKI-A nrPDB Length = 316 Score = 94.0 bits (232), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 85/290 (29%), Positives = 130/290 (44%), Gaps = 51/290 (17%) Query: 347 VLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMV-EKRVLALPGKPPFLTQ 405 VLG+G+ +V T + YAVKI++K Q + + E +L + + Sbjct: 20 VLGEGAHARVQTCINLITSQEYAVKIIEK----QPGHIRSRVFREVEMLYQCQGHRNVLE 75 Query: 406 LHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYR 465 L F+ DR Y V E + GG ++ HI + F E A ++A L FL +KGI +R Sbjct: 76 LIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHNKGIAHR 135 Query: 466 DLKLDNVMLDSEGH---IKIADFGMCKENIWDG----VTTK---TFCGTPDYIAPEII-- 513 DLK +N++ + +KI DFG+ +G ++T T CG+ +Y+APE++ Sbjct: 136 DLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEA 195 Query: 514 ---AYQPYGKSVDWWAFGVLLYEMLAGQAPFEGE-------DEDE--------LFQSIME 555 Y K D W+ GV+LY +L+G PF G D E LF+SI E Sbjct: 196 FSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQNMLFESIQE 255 Query: 556 HNVAYP----KSMSKEAVAICKGLMTKHPGKRL------------GCGPE 589 +P +S A + L+ + +RL GC PE Sbjct: 256 GKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQGCAPE 305 >2FO0-A nrPDB Length = 495 Score = 93.6 bits (231), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 66/233 (28%), Positives = 115/233 (49%), Gaps = 11/233 (4%) Query: 324 TISKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDD 383 T+ N ++ M+ TD LG G +G+V K AVK LK+D + ++ Sbjct: 201 TVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEF 260 Query: 384 VECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHA 443 ++ V K + K P L QL Y + E++ G+L+ ++++ R +E +A Sbjct: 261 LKEAAVMKEI-----KHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNR-QEVNA 314 Query: 444 V---FYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKT 500 V + A +I+ + +L+ K I+R+L N ++ +K+ADFG+ + D T Sbjct: 315 VVLLYMATQISSAMEYLEKKNFIHRNLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHA 374 Query: 501 FCGTP-DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQ 551 P + APE +AY + D WAFGVLL+E+ G +P+ G D ++++ Sbjct: 375 GAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYE 427 >4UY9-A nrPDB Length = 323 Score = 93.2 bits (230), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 77/240 (32%), Positives = 118/240 (49%), Gaps = 33/240 (13%) Query: 347 VLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTM----VEKRVLALPGKPPF 402 ++G G FGKV + G DE+ AVK + D D+D+ T+ E ++ A+ P Sbjct: 16 IIGIGGFGKVYRAFWIG-DEV-AVKAARHD---PDEDISQTIENVRQEAKLFAMLKHPNI 70 Query: 403 LTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGI 462 + C + + L VME+ GG L + R V +A +IA G+ +L + I Sbjct: 71 IALRGVCLKEPN-LCLVMEFARGGPL-NRVLSGKRIPPDILVNWAVQIARGMNYLHDEAI 128 Query: 463 ---IYRDLKLDNVMLD--------SEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPE 511 I+RDLK N+++ S +KI DFG+ +E W T + GT ++APE Sbjct: 129 VPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLARE--WHRTTKMSAAGTYAWMAPE 186 Query: 512 IIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAI 571 +I + K D W++GVLL+E+L G+ PF G D VAY +M+K A+ I Sbjct: 187 VIRASMFSKGSDVWSYGVLLWELLTGEVPFRGID---------GLAVAYGVAMNKLALPI 237 >1PHK-A nrPDB Length = 298 Score = 93.2 bits (230), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 69/229 (30%), Positives = 110/229 (48%), Gaps = 19/229 (8%) Query: 347 VLGKGSFGKVMLSERKGTDELYAVKILKKDVV----IQDDDV----ECTMVEKRVLALPG 398 +LG+G V K T + YAVKI+ DV ++V E T+ E +L Sbjct: 24 ILGRGVSSVVRRCIHKPTCKEYAVKII--DVTGGGSFSAEEVQELREATLKEVDILRKVS 81 Query: 399 KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQ 458 P + QL ++T + V + + G+L ++ + E + + L Sbjct: 82 GHPNIIQLKDTYETNTFFFLVFDLMKKGELFDYLTEKVTLSEKETRKIMRALLEVICALH 141 Query: 459 SKGIIYRDLKLDNVMLDSEGHIKIADFGM-CKENIWDGVTTKTFCGTPDYIAPEIIA--- 514 I++RDLK +N++LD + +IK+ DFG C+ + G + CGTP Y+APEII Sbjct: 142 KLNIVHRDLKPENILLDDDMNIKLTDFGFSCQLD--PGEKLREVCGTPSYLAPEIIECSM 199 Query: 515 ---YQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAY 560 + YGK VD W+ GV++Y +LAG PF + + + IM N + Sbjct: 200 NDNHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQF 248 >6NPU-A nrPDB Length = 298 Score = 92.8 bits (229), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 68/233 (29%), Positives = 116/233 (49%), Gaps = 13/233 (5%) Query: 328 FDNNGNRDR--MKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVE 385 F + N D+ M+ TD LG G +G+V K AVK LK+D + ++ ++ Sbjct: 12 FQGSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLK 71 Query: 386 CTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAV- 444 V K + K P L QL Y + E++ G+L+ ++++ R +E +AV Sbjct: 72 EAAVMKEI-----KHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNR-QEVNAVV 125 Query: 445 --FYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFC 502 + A +I+ + +L+ K I+RDL N ++ +K+ADFG+ + D T Sbjct: 126 LLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGA 185 Query: 503 GTP-DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSI 553 P + APE +AY + D WAFGVLL+E+ G +P+ G D ++++ + Sbjct: 186 KFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELL 238 >6CCF-A nrPDB Length = 290 Score = 92.8 bits (229), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 61/191 (31%), Positives = 101/191 (52%), Gaps = 11/191 (5%) Query: 414 DRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVM 473 D LY V + + G +M + F E A Y ++ +GL +L + I++RD+K N++ Sbjct: 103 DNLYLVFDLLRKGPVM-EVPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLL 161 Query: 474 LDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEII--AYQPY-GKSVDWWAFGVL 530 L +GH+KIADFG+ + + + GTP ++APE I + Q + GK++D WA GV Sbjct: 162 LGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVT 221 Query: 531 LYEMLAGQAPFEGEDEDELFQSIMEHNVAYPK--SMSKEAVAICKGLMTKHPGKRLGCGP 588 LY + G+ PF + L + I V +P+ +S+E + ++ K+P R+G Sbjct: 222 LYCFVYGKCPFIDDFILALHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGV-- 279 Query: 589 EGERDIKEHAF 599 DIK H + Sbjct: 280 ---PDIKLHPW 287 >6CQF-A nrPDB Length = 297 Score = 92.8 bits (229), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 57/204 (27%), Positives = 102/204 (50%), Gaps = 9/204 (4%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG-KP 400 ++ L LG G++G+V + K + +L A+K++K + DDDV + ++K +L L + Sbjct: 18 YDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKME---PDDDV--STLQKEILILKTCRH 72 Query: 401 PFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSK 460 + H + + +L+ ME+ G L Q G E + E+ GL +L S+ Sbjct: 73 ANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSQ 132 Query: 461 GIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQ---P 517 I+RD+K N++++ G +++ADFG+ + F GTP ++APE+ A Sbjct: 133 KKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLAFIGTPYWMAPEVAAVALKGG 192 Query: 518 YGKSVDWWAFGVLLYEMLAGQAPF 541 Y + D W+ G+ E+ Q P Sbjct: 193 YNELCDIWSLGITAIELAELQPPL 216 >4Y93-A nrPDB Length = 446 Score = 92.4 bits (228), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 57/205 (27%), Positives = 112/205 (54%), Gaps = 9/205 (4%) Query: 341 DFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKP 400 D FL LG G FG V + +G ++ A+K++K+ + +D+ +E E +V+ Sbjct: 189 DLTFLKELGTGQFGVVKYGKWRGQYDV-AIKMIKEGSMSEDEFIE----EAKVMMNLSHE 243 Query: 401 PFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQV-GRFKEPHAVFYAAEIAIGLFFLQS 459 L QL+ ++ + EY+ G L+ +++++ RF+ + ++ + +L+S Sbjct: 244 K-LVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLES 302 Query: 460 KGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTP-DYIAPEIIAYQPY 518 K ++RDL N +++ +G +K++DFGM + + D T+ T P + +PE++ Y + Sbjct: 303 KQFLHRDLAARNCLVNDQGVVKVSDFGMTRYVLDDEYTSSTGSKFPVKWASPEVLMYSKF 362 Query: 519 GKSVDWWAFGVLLYEMLA-GQAPFE 542 D WAFGVL++E+ + G+ P+E Sbjct: 363 SSKSDIWAFGVLMWEIYSLGKMPYE 387 >2UV2-A nrPDB Length = 325 Score = 92.0 bits (227), Expect = 7e-19, Method: Compositional matrix adjust. Identities = 60/199 (30%), Positives = 99/199 (49%), Gaps = 10/199 (5%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 407 LG G+FGKV ++ K T L A K++ ++++E MVE +LA P + +L Sbjct: 45 LGDGAFGKVYKAQNKETSVLAAAKVIDTK---SEEELEDYMVEIDILA-SCDHPNIVKLL 100 Query: 408 SCFQTMDRLYFVMEYVNGGDLMYHIQQVGR-FKEPHAVFYAAEIAIGLFFLQSKGIIYRD 466 F + L+ ++E+ GG + + ++ R E + L +L II+RD Sbjct: 101 DAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHDNKIIHRD 160 Query: 467 LKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQ-----PYGKS 521 LK N++ +G IK+ADFG+ +N +F GTP ++APE++ + PY Sbjct: 161 LKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYK 220 Query: 522 VDWWAFGVLLYEMLAGQAP 540 D W+ G+ L EM + P Sbjct: 221 ADVWSLGITLIEMAEIEPP 239 >2X4F-A nrPDB Length = 373 Score = 92.0 bits (227), Expect = 7e-19, Method: Compositional matrix adjust. Identities = 61/211 (28%), Positives = 105/211 (49%), Gaps = 8/211 (3%) Query: 347 VLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQL 406 +LG G FG+V E T A KI+K + ++V+ + L L QL Sbjct: 96 ILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKEEVKNEISVMNQLDHAN----LIQL 151 Query: 407 HSCFQTMDRLYFVMEYVNGGDLMYHI-QQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYR 465 + F++ + + VMEYV+GG+L I + E + + +I G+ + I++ Sbjct: 152 YDAFESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQMYILHL 211 Query: 466 DLKLDNVMLDSEG--HIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVD 523 DLK +N++ + IKI DFG+ + K GTP+++APE++ Y D Sbjct: 212 DLKPENILCVNRDAKQIKIIDFGLARR-YKPREKLKVNFGTPEFLAPEVVNYDFVSFPTD 270 Query: 524 WWAFGVLLYEMLAGQAPFEGEDEDELFQSIM 554 W+ GV+ Y +L+G +PF G+++ E +I+ Sbjct: 271 MWSVGVIAYMLLSGLSPFLGDNDAETLNNIL 301 >2XYN-A nrPDB Length = 292 Score = 91.7 bits (226), Expect = 9e-19, Method: Compositional matrix adjust. Identities = 67/223 (30%), Positives = 111/223 (49%), Gaps = 11/223 (4%) Query: 333 NRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKR 392 ++ M+ TD LG G +G+V + K AVK LK+D + ++ ++ V K Sbjct: 25 DKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKE 84 Query: 393 VLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAV---FYAAE 449 + K P L QL Y V EY+ G+L+ ++++ R +E AV + A + Sbjct: 85 I-----KHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNR-EEVTAVVLLYMATQ 138 Query: 450 IAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTP-DYI 508 I+ + +L+ K I+RDL N ++ +K+ADFG+ + D T P + Sbjct: 139 ISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWT 198 Query: 509 APEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELF 550 APE +AY + D WAFGVLL+E+ G +P+ G D +++ Sbjct: 199 APESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVY 241 >5A46-A nrPDB Length = 386 Score = 91.3 bits (225), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 79/281 (28%), Positives = 131/281 (46%), Gaps = 42/281 (14%) Query: 334 RDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDE-------LYAVKILKKDVVIQDDDVEC 386 RDR+ L LG+G FG+V+L+E G D+ AVK+LK D + D+ Sbjct: 39 RDRLVLGK-----PLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDAT--EKDLSD 91 Query: 387 TMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFY 446 + E ++ + GK + L LY ++EY + G+L ++Q + P + Y Sbjct: 92 LISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQA----RRPPGLEY 147 Query: 447 --------------------AAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFG 486 A ++A G+ +L SK I+RDL NV++ + +KIADFG Sbjct: 148 CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFG 207 Query: 487 MCKENIWDGVTTKTFCG--TPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEG 543 + ++ KT G ++APE + + Y D W+FGVLL+E+ G +P+ G Sbjct: 208 LARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPG 267 Query: 544 EDEDELFQSIME-HNVAYPKSMSKEAVAICKGLMTKHPGKR 583 +ELF+ + E H + P + + E + + P +R Sbjct: 268 VPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQR 308 >3DTC-A nrPDB Length = 271 Score = 91.3 bits (225), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 71/230 (30%), Positives = 113/230 (49%), Gaps = 24/230 (10%) Query: 347 VLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTM----VEKRVLALPGKPPF 402 ++G G FGKV + G DE+ AVK + D D+D+ T+ E ++ A+ P Sbjct: 14 IIGIGGFGKVYRAFWIG-DEV-AVKAARHD---PDEDISQTIENVRQEAKLFAMLKHPNI 68 Query: 403 LTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGI 462 + C + + L VME+ GG L + R V +A +IA G+ +L + I Sbjct: 69 IALRGVCLKEPN-LCLVMEFARGGPL-NRVLSGKRIPPDILVNWAVQIARGMNYLHDEAI 126 Query: 463 ---IYRDLKLDNVMLD--------SEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPE 511 I+RDLK N+++ S +KI DFG+ +E W T + G ++APE Sbjct: 127 VPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLARE--WHRTTKMSAAGAYAWMAPE 184 Query: 512 IIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYP 561 +I + K D W++GVLL+E+L G+ PF G D + + + +A P Sbjct: 185 VIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALP 234 >3TT0-A nrPDB Length = 382 Score = 90.9 bits (224), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 79/281 (28%), Positives = 132/281 (46%), Gaps = 42/281 (14%) Query: 334 RDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDE-------LYAVKILKKDVVIQDDDVEC 386 RDR+ L LG+G+FG+V+L+E G D+ AVK+LK D + D+ Sbjct: 68 RDRLVLGK-----PLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDAT--EKDLSD 120 Query: 387 TMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFY 446 + E ++ + GK + L LY ++EY + G+L ++Q + P + Y Sbjct: 121 LISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQA----RRPPGLEY 176 Query: 447 --------------------AAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFG 486 A ++A G+ +L SK I+RDL NV++ + +KIADFG Sbjct: 177 SYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFG 236 Query: 487 MCKENIWDGVTTKTFCGT--PDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEG 543 + ++ KT G ++APE + + Y D W+FGVLL+E+ G +P+ G Sbjct: 237 LARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPG 296 Query: 544 EDEDELFQSIME-HNVAYPKSMSKEAVAICKGLMTKHPGKR 583 +ELF+ + E H + P + + E + + P +R Sbjct: 297 VPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQR 337 >5VO2-A nrPDB Length = 300 Score = 90.9 bits (224), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 49/145 (33%), Positives = 84/145 (57%), Gaps = 3/145 (2%) Query: 418 FVMEYVNGGDLMYHIQQVGRFKEPHAVF-YAAEIAIGLFFLQSKGIIYRDLKLDNVMLDS 476 +ME+ G L Y + + GR P + ++ IA G+ +L II+RDLK N+++ Sbjct: 77 ILMEFCAQGQL-YEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLITY 135 Query: 477 EGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA 536 + +KI+DFG KE + D T +F GT ++APE+I +P + VD W+FGV+L+E+L Sbjct: 136 DDVVKISDFGTSKE-LSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT 194 Query: 537 GQAPFEGEDEDELFQSIMEHNVAYP 561 G+ P++ D + + +++ P Sbjct: 195 GEIPYKDVDSSAIIWGVGSNSLHLP 219 >5L2Q-C nrPDB Length = 320 Score = 90.5 bits (223), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 57/186 (30%), Positives = 94/186 (50%), Gaps = 9/186 (4%) Query: 427 DLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGH-IKIADF 485 +L +++ + R E V ++ + L K I++RDLKL N++L+ H I I +F Sbjct: 139 NLQHYVIKEKRLSERETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNF 198 Query: 486 GMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY-GKSVDWWAFGVLLYEMLAGQAPFEGE 544 + K + +G K G+P YI+P++++ +PY GK D WA GV+L+ ML GQ PF Sbjct: 199 CLGKHLVSEGDLLKDQRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPFYDS 258 Query: 545 DEDELFQSI--MEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRY 602 ELF+ I E+ + +S+ V + + L+ P +RL D+ E Sbjct: 259 IPQELFRKIKAAEYTIPEDGRVSENTVCLIRKLLVLDPQQRLAAA-----DVLEALSAII 313 Query: 603 IDWEKL 608 W+ L Sbjct: 314 ASWQSL 319 >3GQL-A nrPDB Length = 326 Score = 90.5 bits (223), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 75/267 (28%), Positives = 127/267 (47%), Gaps = 37/267 (13%) Query: 348 LGKGSFGKVMLSERKGTDE-------LYAVKILKKDVVIQDDDVECTMVEKRVLALPGKP 400 LG+G+FG+V+L+E G D+ AVK+LK D + D+ + E ++ + GK Sbjct: 36 LGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDAT--EKDLSDLISEMEMMKMIGKH 93 Query: 401 PFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFY-------------- 446 + L LY ++EY + G+L ++Q + P + Y Sbjct: 94 KNIINLLGACTQDGPLYVIVEYASKGNLREYLQA----RRPPGLEYCYNPSHNPEEQLSS 149 Query: 447 ------AAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKT 500 A ++A G+ +L SK I+RDL NV++ + +KIADFG+ ++ KT Sbjct: 150 KDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKT 209 Query: 501 FCGT--PDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIME-H 556 G ++APE + + Y D W+FGVLL+E+ G +P+ G +ELF+ + E H Sbjct: 210 TNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGH 269 Query: 557 NVAYPKSMSKEAVAICKGLMTKHPGKR 583 + P + + E + + P +R Sbjct: 270 RMDKPSNCTNELYMMMRDCWHAVPSQR 296 >2ENN-A nrPDB Length = 77 Score = 90.1 bits (222), Expect = 2e-18, Method: Composition-based stats. Identities = 36/68 (52%), Positives = 48/68 (70%) Query: 22 RKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEF 81 R+GA++Q VH VK H+FTA FF QPTFCS C +F+WG KQG+QC+ C +HK+C + Sbjct: 9 RRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFVWGLNKQGYQCRQCNAAIHKKCIDK 68 Query: 82 VTFSCPGA 89 V C G+ Sbjct: 69 VIAKCTGS 76 Score = 46.6 bits (109), Expect = 3e-05, Method: Composition-based stats. Identities = 18/50 (36%), Positives = 27/50 (54%) Query: 102 HKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLC 151 H+F + PTFC C ++GL QG +C C +HK+C+ V + C Sbjct: 24 HEFTATFFPQPTFCSVCHEFVWGLNKQGYQCRQCNAAIHKKCIDKVIAKC 73 >4BGQ-A nrPDB Length = 304 Score = 90.1 bits (222), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 66/228 (28%), Positives = 116/228 (50%), Gaps = 12/228 (5%) Query: 327 KFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVEC 386 K N GN + F L V+G+G++G V+ K T E+ A+K K ++++V+ Sbjct: 3 KIPNIGN----VMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSE--ENEEVKE 56 Query: 387 TMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAV-F 445 T + + + K + +L F+ +LY V EYV +++ ++++ P V Sbjct: 57 TTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEK-NMLELLEEMPNGVPPEKVKS 115 Query: 446 YAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDG--VTTKTFCG 503 Y ++ + + I++RD+K +N+++ +K+ DFG + N+ +G Sbjct: 116 YIYQLIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFAR-NLSEGNNANYDEEVA 174 Query: 504 TPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDE-DELF 550 T Y +PE++ PYGKSVD W+ G +L E+ GQ F GE E D+LF Sbjct: 175 TRWYRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLF 222 >2OZA-A nrPDB Length = 356 Score = 90.1 bits (222), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 67/200 (33%), Positives = 98/200 (49%), Gaps = 10/200 (5%) Query: 347 VLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQL 406 VLG G GKV+ K T E +A+K+L+ D +VE + R P + Sbjct: 25 VLGLGINGKVLQIFNKRTQEKFALKMLQ-DCPKARREVE---LHWRASQCPHIVRIVDVY 80 Query: 407 HSCFQTMDRLYFVMEYVNGGDLMYHIQQVG--RFKEPHAVFYAAEIAIGLFFLQSKGIIY 464 + + L VME ++GG+L IQ G F E A I + +L S I + Sbjct: 81 ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAH 140 Query: 465 RDLKLDNVMLDSE---GHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKS 521 RD+K +N++ S+ +K+ DFG KE T T C TP Y+APE++ + Y KS Sbjct: 141 RDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLT-TPCYTPYYVAPEVLGPEKYDKS 199 Query: 522 VDWWAFGVLLYEMLAGQAPF 541 D W+ GV++Y +L G PF Sbjct: 200 CDMWSLGVIMYILLCGYPPF 219 >1NY3-A nrPDB Length = 400 Score = 90.1 bits (222), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 67/200 (33%), Positives = 98/200 (49%), Gaps = 10/200 (5%) Query: 347 VLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQL 406 VLG G GKV+ K T E +A+K+L+ D +VE + R P + Sbjct: 69 VLGLGINGKVLQIFNKRTQEKFALKMLQ-DCPKARREVE---LHWRASQCPHIVRIVDVY 124 Query: 407 HSCFQTMDRLYFVMEYVNGGDLMYHIQQVG--RFKEPHAVFYAAEIAIGLFFLQSKGIIY 464 + + L VME ++GG+L IQ G F E A I + +L S I + Sbjct: 125 ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAH 184 Query: 465 RDLKLDNVMLDSE---GHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKS 521 RD+K +N++ S+ +K+ DFG KE T T C TP Y+APE++ + Y KS Sbjct: 185 RDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLT-TPCYTPYYVAPEVLGPEKYDKS 243 Query: 522 VDWWAFGVLLYEMLAGQAPF 541 D W+ GV++Y +L G PF Sbjct: 244 CDMWSLGVIMYILLCGYPPF 263 >4KIK-B nrPDB Length = 677 Score = 89.4 bits (220), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 64/207 (30%), Positives = 100/207 (48%), Gaps = 18/207 (8%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVE-------KRVLALPGKP 400 LG G FG V+ + T E A+K ++++ ++ + C ++ V+A P Sbjct: 27 LGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQIMRRLTHPNVVAARDVP 86 Query: 401 PFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR---FKEPHAVFYAAEIAIGLFFL 457 + L D MEY GGDL ++ Q +E + ++IA L +L Sbjct: 87 EGMQNLAP----NDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALRYL 142 Query: 458 QSKGIIYRDLKLDNVMLDS-EGHI--KIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA 514 II+RDLK +N++L E + KI D G KE + G +F GT Y+APE++ Sbjct: 143 HENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKE-LDQGSLCTSFVGTLQYLAPELLE 201 Query: 515 YQPYGKSVDWWAFGVLLYEMLAGQAPF 541 Q Y +VD+W+FG L +E + G PF Sbjct: 202 QQKYTVTVDYWSFGTLAFECITGFRPF 228 >3KA0-A nrPDB Length = 320 Score = 89.0 bits (219), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 66/200 (33%), Positives = 98/200 (49%), Gaps = 10/200 (5%) Query: 347 VLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQL 406 VLG G GKV+ K T E +A+K+L+ D +VE + R P + Sbjct: 23 VLGLGINGKVLQIFNKRTQEKFALKMLQ-DCPKARREVE---LHWRASQCPHIVRIVDVY 78 Query: 407 HSCFQTMDRLYFVMEYVNGGDLMYHIQQVG--RFKEPHAVFYAAEIAIGLFFLQSKGIIY 464 + + L VME ++GG+L IQ G F E A I + +L S I + Sbjct: 79 ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAH 138 Query: 465 RDLKLDNVMLDSE---GHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKS 521 RD+K +N++ S+ +K+ DFG KE T+ C TP Y+APE++ + Y KS Sbjct: 139 RDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTEP-CYTPYYVAPEVLGPEKYDKS 197 Query: 522 VDWWAFGVLLYEMLAGQAPF 541 D W+ GV++Y +L G PF Sbjct: 198 CDMWSLGVIMYILLCGYPPF 217 >3COM-A nrPDB Length = 314 Score = 89.0 bits (219), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 60/201 (29%), Positives = 96/201 (47%), Gaps = 7/201 (3%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 F+ L LG+GS+G V + K T ++ A+K V + D++ + E ++ P Sbjct: 31 FDVLEKLGEGSYGSVYKAIHKETGQIVAIK-----QVPVESDLQEIIKEISIMQQCDSPH 85 Query: 402 FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR-FKEPHAVFYAAEIAIGLFFLQSK 460 + S F+ D L+ VMEY G + I+ + E GL +L Sbjct: 86 VVKYYGSYFKNTD-LWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFM 144 Query: 461 GIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGK 520 I+RD+K N++L++EGH K+ADFG+ + T GTP ++APE+I Y Sbjct: 145 RKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNC 204 Query: 521 SVDWWAFGVLLYEMLAGQAPF 541 D W+ G+ EM G+ P+ Sbjct: 205 VADIWSLGITAIEMAEGKPPY 225 >2XNP-A nrPDB Length = 279 Score = 89.0 bits (219), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 65/226 (28%), Positives = 104/226 (46%), Gaps = 13/226 (5%) Query: 341 DFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKP 400 D+ L +G GS+G+ RK ++ K L + + + + +V + L K Sbjct: 7 DYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAE--KQMLVSEVNLLRELKH 64 Query: 401 PFLTQLHSCF--QTMDRLYFVMEYVNGGDLMYHIQQVGR----FKEPHAVFYAAEIAIGL 454 P + + + +T LY VMEY GGDL I + + E + ++ + L Sbjct: 65 PNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLAL 124 Query: 455 FFLQSKG-----IIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIA 509 + +++RDLK NV LD + ++K+ DFG+ + D KTF GTP Y++ Sbjct: 125 KECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMS 184 Query: 510 PEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIME 555 PE + Y + D W+ G LLYE+ A PF + EL I E Sbjct: 185 PEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIRE 230 >3SXS-A nrPDB Length = 268 Score = 89.0 bits (219), Expect = 7e-18, Method: Compositional matrix adjust. Identities = 66/251 (26%), Positives = 120/251 (47%), Gaps = 10/251 (3%) Query: 337 MKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLAL 396 +K + L LG G FG V L + KG ++ AVK++K+ + +D+ ++ + Sbjct: 5 LKREEITLLKELGSGQFGVVKLGKWKGQYDV-AVKMIKEGSMSEDE-----FFQEAQTMM 58 Query: 397 PGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVF-YAAEIAIGLF 455 P L + + +Y V EY++ G L+ +++ G+ EP + ++ G+ Sbjct: 59 KLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMA 118 Query: 456 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTP-DYIAPEIIA 514 FL+S I+RDL N ++D + +K++DFGM + + D + P + APE+ Sbjct: 119 FLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFH 178 Query: 515 YQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIME-HNVAYPKSMSKEAVAIC 572 Y Y D WAFG+L++E+ + G+ P++ E+ + + H + P S I Sbjct: 179 YFKYSSKSDVWAFGILMWEVFSLGKMPYDLYTNSEVVLKVSQGHRLYRPHLASDTIYQIM 238 Query: 573 KGLMTKHPGKR 583 + P KR Sbjct: 239 YSCWHELPEKR 249 >2PSQ-A nrPDB Length = 370 Score = 88.6 bits (218), Expect = 9e-18, Method: Compositional matrix adjust. Identities = 73/263 (27%), Positives = 124/263 (47%), Gaps = 29/263 (11%) Query: 348 LGKGSFGKVMLSERKGTDE-------LYAVKILKKDVVIQDDDVECTMVEKRVLALPGKP 400 LG+G FG+V+++E G D+ AVK+LK D + D+ + E ++ + GK Sbjct: 89 LGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDAT--EKDLSDLVSEMEMMKMIGKH 146 Query: 401 PFLTQLHSCFQTMDRLYFVMEYVNGGDL-----------MYHIQQVGRFKEPHAVFY--- 446 + L LY ++EY + G+L M + + R E F Sbjct: 147 KNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLV 206 Query: 447 --AAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKE-NIWDGVTTKTFCG 503 ++A G+ +L S+ I+RDL NV++ +KIADFG+ ++ N D T Sbjct: 207 SCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGR 266 Query: 504 TP-DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIME-HNVAY 560 P ++APE + + Y D W+FGVL++E+ G +P+ G +ELF+ + E H + Sbjct: 267 LPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDK 326 Query: 561 PKSMSKEAVAICKGLMTKHPGKR 583 P + + E + + P +R Sbjct: 327 PANCTNELYMMMRDCWHAVPSQR 349 >4LDC-A nrPDB Length = 149 Score = 88.6 bits (218), Expect = 9e-18, Method: Compositional matrix adjust. Identities = 52/130 (40%), Positives = 75/130 (57%), Gaps = 6/130 (4%) Query: 157 ERRGRIYIQAHIDRE---VLIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTK 213 E RGRI I + +L+ +VR A +L MD NG SDPYVK L PD +SK KT Sbjct: 2 EERGRILISLKYSSQKQGLLVGIVRCA-HLAAMDANGYSDPYVKTYLKPDVDKKSKHKTA 60 Query: 214 TIKCSLNPEWNETFRFQLKESDKDRR-LSVEIWDWDLTSRNDFMGSLSFGISELQKAGVD 272 K +LNPE+NE F +++K D ++ L V +WD+D+ NDF+G + GI+ + + Sbjct: 61 VKKKTLNPEFNEEFCYEIKHGDLAKKTLEVTVWDYDIGKSNDFIGGVVLGINA-KGERLK 119 Query: 273 GWFKLLSQEE 282 WF L ++ Sbjct: 120 HWFDCLKNKD 129 >3IS5-A nrPDB Length = 285 Score = 88.2 bits (217), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 74/253 (29%), Positives = 121/253 (47%), Gaps = 17/253 (6%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG-KP 400 F F LG G+FG V L E + + +K + KD V +E + L Sbjct: 24 FIFKRKLGSGAFGDVHLVEERSSGLERVIKTINKD----RSQVPMEQIEAEIEVLKSLDH 79 Query: 401 PFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAI----GLFF 456 P + ++ F+ +Y VME GG+L+ I + + Y AE+ L + Sbjct: 80 PNIIKIFEVFEDYHNMYIVMETCEGGELLERIVSAQARGKALSEGYVAELMKQMMNALAY 139 Query: 457 LQSKGIIYRDLKLDNVML-DSEGH--IKIADFGMCKENIWDGVTTKTFCGTPDYIAPEII 513 S+ ++++DLK +N++ D+ H IKI DFG+ + D +T GT Y+APE+ Sbjct: 140 FHSQHVVHKDLKPENILFQDTSPHSPIKIIDFGLAELFKSDEHSTNA-AGTALYMAPEVF 198 Query: 514 AYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQ--SIMEHNVAYP-KSMSKEAVA 570 K D W+ GV++Y +L G PF G +E+ Q + E N A + ++ +AV Sbjct: 199 KRDVTFK-CDIWSAGVVMYFLLTGCLPFTGTSLEEVQQKATYKEPNYAVECRPLTPQAVD 257 Query: 571 ICKGLMTKHPGKR 583 + K ++TK P +R Sbjct: 258 LLKQMLTKDPERR 270 >5TQX-A nrPDB Length = 655 Score = 88.2 bits (217), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 64/207 (30%), Positives = 100/207 (48%), Gaps = 19/207 (9%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVE-------KRVLALPGKP 400 LG G FG V L + + D A+K + ++ ++ + C ++ V+ P Sbjct: 16 LGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCHEIQIMKKLNHANVVKACDVP 75 Query: 401 PFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHI---QQVGRFKEPHAVFYAAEIAIGLFFL 457 L L D MEY +GGDL + + KE + ++I G+ +L Sbjct: 76 EELNIL-----IHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSGIRYL 130 Query: 458 QSKGIIYRDLKLDNVML-DSEGHI--KIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA 514 II+RDLK +N++L D G I KI D G K ++ G F GT Y+APE+ Sbjct: 131 HENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAK-DVDQGELCTEFVGTLQYLAPELFE 189 Query: 515 YQPYGKSVDWWAFGVLLYEMLAGQAPF 541 +PY +VD+W+FG +++E +AG PF Sbjct: 190 NKPYTATVDYWSFGTMVFECIAGYRPF 216 >3FXW-A nrPDB Length = 336 Score = 88.2 bits (217), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 64/204 (31%), Positives = 100/204 (49%), Gaps = 19/204 (9%) Query: 347 VLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQL 406 VLG G GKV+ + T + A+K+L + + V+ A G P + + Sbjct: 36 VLGLGVNGKVLECFHRRTGQKCALKLLYDSPKARQE------VDHHWQASGG--PHIVCI 87 Query: 407 HSCFQTMDR----LYFVMEYVNGGDLMYHIQQVG--RFKEPHAVFYAAEIAIGLFFLQSK 460 ++ M L +ME + GG+L IQ+ G F E A +I + FL S Sbjct: 88 LDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLHSH 147 Query: 461 GIIYRDLKLDNVMLDS---EGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQP 517 I +RD+K +N++ S + +K+ DFG KE + + T C TP Y+APE++ + Sbjct: 148 NIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNALQTP--CYTPYYVAPEVLGPEK 205 Query: 518 YGKSVDWWAFGVLLYEMLAGQAPF 541 Y KS D W+ GV++Y +L G PF Sbjct: 206 YDKSCDMWSLGVIMYILLCGFPPF 229 >1TKI-A nrPDB Length = 321 Score = 88.2 bits (217), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 64/249 (25%), Positives = 110/249 (44%), Gaps = 17/249 (6%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 407 LG+G FG V + + Y K +K ++ D E +L + L LH Sbjct: 13 LGRGEFGIVHRCVETSSKKTYMAKFVK----VKGTDQVLVKKEISILNIARHRNIL-HLH 67 Query: 408 SCFQTMDRLYFVMEYVNGGDLMYHIQQVG-RFKEPHAVFYAAEIAIGLFFLQSKGIIYRD 466 F++M+ L + E+++G D+ I E V Y ++ L FL S I + D Sbjct: 68 ESFESMEELVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCEALQFLHSHNIGHFD 127 Query: 467 LKLDNVMLDSE--GHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDW 524 ++ +N++ + IKI +FG ++ + G + P+Y APE+ + + D Sbjct: 128 IRPENIIYQTRRSSTIKIIEFGQARQ-LKPGDNFRLLFTAPEYYAPEVHQHDVVSTATDM 186 Query: 525 WAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYP------KSMSKEAVAICKGLMTK 578 W+ G L+Y +L+G PF E ++ ++IM N Y K +S EA+ L+ K Sbjct: 187 WSLGTLVYVLLSGINPFLAETNQQIIENIM--NAEYTFDEEAFKEISIEAMDFVDRLLVK 244 Query: 579 HPGKRLGCG 587 R+ Sbjct: 245 ERKSRMTAS 253 >4E93-A nrPDB Length = 377 Score = 87.8 bits (216), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 61/199 (30%), Positives = 100/199 (50%), Gaps = 9/199 (4%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 407 +G+G+FG+V + + L AVK ++ + D + E R+L P + + Sbjct: 122 IGRGNFGEVFSGRLRADNTLVAVKSCRE--TLPPDLKAKFLQEARILKQYSHPNIVRLIG 179 Query: 408 SCFQTMDRLYFVMEYVNGGDLMYHIQQVG-RFKEPHAVFYAAEIAIGLFFLQSKGIIYRD 466 C Q +Y VME V GGD + ++ G R + + + A G+ +L+SK I+RD Sbjct: 180 VCTQKQP-IYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRD 238 Query: 467 LKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKT--FCGTP-DYIAPEIIAYQPYGKSVD 523 L N ++ + +KI+DFGM +E DGV + P + APE + Y Y D Sbjct: 239 LAARNCLVTEKNVLKISDFGMSREEA-DGVYAASGGLRQVPVKWTAPEALNYGRYSSESD 297 Query: 524 WWAFGVLLYEMLA-GQAPF 541 W+FG+LL+E + G +P+ Sbjct: 298 VWSFGILLWETFSLGASPY 316 >2WTK-C nrPDB Length = 305 Score = 87.8 bits (216), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 61/192 (31%), Positives = 97/192 (50%), Gaps = 10/192 (5%) Query: 415 RLYFVMEY-VNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVM 473 ++Y VMEY V G M RF A Y ++ GL +L S+GI+++D+K N++ Sbjct: 82 KMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLL 141 Query: 474 LDSEGHIKIADFGMCK--ENIWDGVTTKTFCGTPDYIAPEIIAYQPY--GKSVDWWAFGV 529 L + G +KI+ G+ + T +T G+P + PEI G VD W+ GV Sbjct: 142 LTTGGTLKISALGVAEALHPFAADDTCRTSQGSPAFQPPEIANGLDTFSGFKVDIWSAGV 201 Query: 530 LLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPE 589 LY + G PFEG++ +LF++I + + A P + KG++ P KR Sbjct: 202 TLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSDLLKGMLEYEPAKRFSI--- 258 Query: 590 GERDIKEHAFFR 601 R I++H++FR Sbjct: 259 --RQIRQHSWFR 268 >2BPM-A nrPDB Length = 309 Score = 87.4 bits (215), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 64/218 (29%), Positives = 113/218 (51%), Gaps = 27/218 (12%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 407 +G+G++G V + K T E+ A+K ++ D + + V T + + L P + +L Sbjct: 15 IGEGTYGVVYKARNKLTGEVVALKKIRLDT--ETEGVPSTAIREISLLKELNHPNIVKLL 72 Query: 408 SCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVF---------YAAEIAIGLFFLQ 458 T ++LY V E+++ Q + +F + A+ Y ++ GL F Sbjct: 73 DVIHTENKLYLVFEFLH--------QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 124 Query: 459 SKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCG---TPDYIAPEI-IA 514 S +++RDLK N+++++EG IK+ADFG+ + GV +T+ T Y APEI + Sbjct: 125 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAF---GVPVRTYTHEVVTLWYRAPEILLG 181 Query: 515 YQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDE-DELFQ 551 + Y +VD W+ G + EM+ +A F G+ E D+LF+ Sbjct: 182 CKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFR 219 >4XI2-A nrPDB Length = 446 Score = 87.4 bits (215), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 59/232 (25%), Positives = 119/232 (51%), Gaps = 9/232 (3%) Query: 341 DFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKP 400 D FL LG G FG V + +G ++ A+K++++ + +D+ +E E +V+ Sbjct: 188 DLTFLKELGTGQFGVVKYGKWRGQYDV-AIKMIREGSMSEDEFIE----EAKVMMNLSHE 242 Query: 401 PFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQV-GRFKEPHAVFYAAEIAIGLFFLQS 459 L QL+ ++ + EY+ G L+ +++++ RF+ + ++ + +L+S Sbjct: 243 K-LVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLES 301 Query: 460 KGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTP-DYIAPEIIAYQPY 518 K ++RDL N +++ +G +K++DFG+ + + D T+ P + PE++ Y + Sbjct: 302 KQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKF 361 Query: 519 GKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAV 569 D WAFGVL++E+ + G+ P+E E + I + Y ++ E V Sbjct: 362 SSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASERV 413 >6E4F-A nrPDB Length = 290 Score = 87.4 bits (215), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 60/232 (25%), Positives = 119/232 (51%), Gaps = 9/232 (3%) Query: 341 DFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKP 400 D FL LG G FG V + +G ++ A+K++K+ + +D+ +E E +V+ Sbjct: 32 DLTFLKELGTGQFGVVKYGKWRGQYDV-AIKMIKEGSMSEDEFIE----EAKVMMNLSHE 86 Query: 401 PFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQV-GRFKEPHAVFYAAEIAIGLFFLQS 459 L QL+ ++ + EY+ G L+ +++++ RF+ + ++ + +L+S Sbjct: 87 K-LVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLES 145 Query: 460 KGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTP-DYIAPEIIAYQPY 518 K ++RDL N +++ +G +K++DFG+ + + D T+ P + PE++ Y + Sbjct: 146 KQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKF 205 Query: 519 GKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAV 569 D WAFGVL++E+ + G+ P+E E + I + Y ++ E V Sbjct: 206 SSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKV 257 >4X3F-A nrPDB Length = 337 Score = 87.0 bits (214), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 62/223 (27%), Positives = 99/223 (44%), Gaps = 14/223 (6%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 + ++ G G+V + AVK+LK + + +E E R A+ P Sbjct: 14 YRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHPG 73 Query: 402 FLT-------QLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGL 454 + Q++ +T Y VME VNG L +++ GR HA+ + L Sbjct: 74 IASVHDYGESQMNGEGRTA---YLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRAL 130 Query: 455 FFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVT-TKTFCGTPDYIAPEII 513 + G+++RD+K N+++ G +KI DFG+ K VT T GT YIAPE Sbjct: 131 QIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQA 190 Query: 514 AYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEH 556 + D ++ GV+ YE ++G+ PF G D M+H Sbjct: 191 LGHDASPASDVYSLGVVGYEAVSGKRPFAG---DGALTVAMKH 230 >4K33-A nrPDB Length = 325 Score = 87.0 bits (214), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 74/267 (27%), Positives = 127/267 (47%), Gaps = 37/267 (13%) Query: 348 LGKGSFGKVMLSERKGTDE-------LYAVKILKKDVVIQDDDVECTMVEKRVLALPGKP 400 LG+G+FG+V+++E G D+ AVK+LK D D D+ + E ++ + GK Sbjct: 44 LGEGAFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDAT--DKDLSDLVSEMEMMKMIGKH 101 Query: 401 PFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFY-------------- 446 + L LY ++EY G+L ++ R + P + Y Sbjct: 102 KNIINLLGACTQGGPLYVLVEYAAKGNL----REFLRARRPPGLDYSFDTSKPPEEQLTF 157 Query: 447 ------AAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKE-NIWDGVTTK 499 A ++A G+ +L S+ I+RDL NV++ + +KIADFG+ ++ + D Sbjct: 158 KDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKET 217 Query: 500 TFCGTP-DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIME-H 556 T P ++APE + + Y D W+FGVLL+E+ G +P+ G +ELF+ + E H Sbjct: 218 TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGH 277 Query: 557 NVAYPKSMSKEAVAICKGLMTKHPGKR 583 + P + + + I + P +R Sbjct: 278 RMDKPANCTHDLYMIMRECWHAAPSQR 304 >5X5O-A nrPDB Length = 310 Score = 86.7 bits (213), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 64/231 (27%), Positives = 117/231 (50%), Gaps = 27/231 (11%) Query: 336 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 395 ++K D F G GSFG V ++ D+ AVK L K + ++ ++ + + ++ Sbjct: 11 QIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLK--IEKEAEILSVLSHRNIIQ 68 Query: 396 LPG---KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKE---PHAVFYAAE 449 G +PP V EY + G L +I R +E H + +A + Sbjct: 69 FYGVILEPP-------------NYGIVTEYASLGSLYDYINS-NRSEEMDMDHIMTWATD 114 Query: 450 IAIGLFFLQSKG---IIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPD 506 +A G+ +L + +I+RDLK NV++ ++G +KI DFG + + + T + GT Sbjct: 115 VAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFH--NHTTHMSLVGTFP 172 Query: 507 YIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHN 557 ++APE+I P ++ D +++GV+L+EML + PF+G + ++ ++E N Sbjct: 173 WMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKN 223 >5EG3-A nrPDB Length = 334 Score = 86.3 bits (212), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 71/263 (26%), Positives = 125/263 (47%), Gaps = 29/263 (11%) Query: 348 LGKGSFGKVMLSERKGTDE-------LYAVKILKKDVVIQDDDVECTMVEKRVLALPGKP 400 LG+G+FG+V+++E G D+ AVK+LK D + D+ + E ++ + GK Sbjct: 43 LGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDAT--EKDLSDLVSEMEMMKMIGKH 100 Query: 401 PFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQ-----------QVGRFKEPHAVFY--- 446 + L LY ++ Y + G+L +++ + R E F Sbjct: 101 KNIINLLGACTQDGPLYVIVAYASKGNLREYLRARRPPGMELSPDINRVPEEQMTFKDLV 160 Query: 447 --AAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKE-NIWDGVTTKTFCG 503 ++A G+ +L S+ I+RDL NV++ +KIADFG+ ++ N D T Sbjct: 161 SCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDFFKETTNGR 220 Query: 504 TP-DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIME-HNVAY 560 P ++APE + + Y D W+FGVL++E+ G +P+ G +ELF+ + E H + Sbjct: 221 LPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDK 280 Query: 561 PKSMSKEAVAICKGLMTKHPGKR 583 P + + E + + P +R Sbjct: 281 PANCTNELYMMMRDCWHAVPSQR 303 >1RH8-A nrPDB Length = 142 Score = 86.3 bits (212), Expect = 4e-17, Method: Composition-based stats. Identities = 49/135 (36%), Positives = 73/135 (54%), Gaps = 12/135 (8%) Query: 160 GRIYIQAHIDREVLIVVVRDAKNLVPMDPNGLSDPYVKLKLIP---------DPKSESKQ 210 G I +Q + D LI+ + A+NLVP D NG SDP+VK+ L+P + +E K+ Sbjct: 7 GEIQLQINYDLGNLIIHILQARNLVPRDNNGYSDPFVKVYLLPGRGQVMVVQNASAEYKR 66 Query: 211 KTKTIKCSLNPEWNETFRFQ--LKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQK 268 +TK ++ SLNPEWN+T ++ E + L V +WD+D S NDF+G + +S Sbjct: 67 RTKYVQKSLNPEWNQTVIYKSISMEQLMKKTLEVTVWDYDRFSSNDFLGEVLIDLSSTSH 126 Query: 269 A-GVDGWFKLLSQEE 282 W+ L Q E Sbjct: 127 LDNTPRWYPLKEQTE 141 >4OW8-A nrPDB Length = 283 Score = 85.9 bits (211), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 62/223 (27%), Positives = 99/223 (44%), Gaps = 14/223 (6%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 + ++ G G+V + AVK+LK + + +E E R A+ P Sbjct: 13 YRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHPG 72 Query: 402 FLT-------QLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGL 454 + Q++ +T Y VME VNG L +++ GR HA+ + L Sbjct: 73 IASVHDYGESQMNGEGRTA---YLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRAL 129 Query: 455 FFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVT-TKTFCGTPDYIAPEII 513 + G+++RD+K N+++ G +KI DFG+ K VT T GT YIAPE Sbjct: 130 QIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQA 189 Query: 514 AYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEH 556 + D ++ GV+ YE ++G+ PF G D M+H Sbjct: 190 LGHDASPASDVYSLGVVGYEAVSGKRPFAG---DGALTVAMKH 229 >2ENZ-A nrPDB Length = 65 Score = 85.9 bits (211), Expect = 5e-17, Method: Composition-based stats. Identities = 32/53 (60%), Positives = 41/53 (77%) Query: 102 HKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTD 154 H+FK++ Y SPTFC+HCG+LL+GL QG+KCD C MNVH RC V +LCG + Sbjct: 13 HRFKVYNYKSPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTKVANLCGIN 65 Score = 58.5 bits (140), Expect = 9e-09, Method: Composition-based stats. Identities = 21/50 (42%), Positives = 26/50 (52%) Query: 37 HKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSC 86 H+F +K PTFC HC +WG +QG +C C VH RC V C Sbjct: 13 HRFKVYNYKSPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTKVANLC 62 >6AO5-A nrPDB Length = 362 Score = 85.1 bits (209), Expect = 9e-17, Method: Compositional matrix adjust. Identities = 53/202 (26%), Positives = 102/202 (50%), Gaps = 9/202 (4%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 F+ L LG+GS+G V + K + ++ A+K + + +Q+ E +++++ P Sbjct: 12 FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQ------CDSP 65 Query: 402 FLTQLHSCFQTMDRLYFVMEYVNGGDL--MYHIQQVGRFKEPHAVFYAAEIAIGLFFLQS 459 ++ + + + L+ VMEY G + + ++ ++ A + + GL +L Sbjct: 66 YVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLK-GLEYLHF 124 Query: 460 KGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYG 519 I+R++K N++L++EGH K+ADFG+ + T GTP ++APE+I Y Sbjct: 125 MRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYN 184 Query: 520 KSVDWWAFGVLLYEMLAGQAPF 541 D W+ G+ EM G+ P+ Sbjct: 185 CVADIWSLGITSIEMAEGKPPY 206 >4XCU-A nrPDB Length = 300 Score = 85.1 bits (209), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 76/268 (28%), Positives = 122/268 (45%), Gaps = 25/268 (9%) Query: 334 RDRMKLTDFNFLMVLGKGSFGKVMLSERKGTD-------ELYAVKILKKDVVIQDDDVEC 386 RDR+ L LG+G FG+V+ +E G D AVK+LK + D D+ Sbjct: 16 RDRLVLGK-----PLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNA--SDKDLAD 68 Query: 387 TMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQ-------QVGRFK 439 + E V+ L G+ + L LY ++E G+L ++ G Sbjct: 69 LVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGSSEGPLS 128 Query: 440 EPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTK 499 P V A ++A G+ +L+S+ I+RDL NV++ + +KIADFG+ + K Sbjct: 129 FPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKK 188 Query: 500 TFCG--TPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIME- 555 T G ++APE + + Y D W+FG+LL+E+ G +P+ G +ELF + E Sbjct: 189 TSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREG 248 Query: 556 HNVAYPKSMSKEAVAICKGLMTKHPGKR 583 H + P E + + P +R Sbjct: 249 HRMDRPPHCPPELYGLMRECWHAAPSQR 276 >4X7Q-B nrPDB Length = 312 Score = 85.1 bits (209), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 67/254 (26%), Positives = 119/254 (46%), Gaps = 19/254 (7%) Query: 340 TDFNFLMVLGKGSFGKVMLSERKGTDEL-YAVKILKKDVVIQ----DDDVECTMVEKRV- 393 ++ +LGKG FG V R TD L A+K++ ++ V+ D V C + + Sbjct: 31 AEYRLGPLLGKGGFGTVFAGHRL-TDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLW 89 Query: 394 -LALPGKPPFLTQLHSCFQTMDRLYFVMEY-VNGGDLMYHIQQVGRFKEPHAVFYAAEIA 451 + G P + +L F+T + V+E + DL +I + G E + + ++ Sbjct: 90 KVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVV 149 Query: 452 IGLFFLQSKGIIYRDLKLDNVMLD-SEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAP 510 + S+G+++RD+K +N+++D G K+ DFG + F GT Y P Sbjct: 150 AAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFG--SGALLHDEPYTDFDGTRVYSPP 207 Query: 511 EIIA-YQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAV 569 E I+ +Q + W+ G+LLY+M+ G PFE + Q I+E + +P +S + Sbjct: 208 EWISRHQYHALPATVWSLGILLYDMVCGDIPFERD------QEILEAELHFPAHVSPDCC 261 Query: 570 AICKGLMTKHPGKR 583 A+ + + P R Sbjct: 262 ALIRRCLAPKPSSR 275 >5LOB-A nrPDB Length = 162 Score = 84.7 bits (208), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 45/111 (40%), Positives = 66/111 (59%), Gaps = 3/111 (2%) Query: 157 ERRGRIYIQAHIDREV--LIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKT 214 E RG+I + + LIV + +L MD NG SDP+VKL L PD ++K KT+ Sbjct: 21 EERGKILVSLMYSTQQGGLIVGIIRCVHLAAMDANGYSDPFVKLWLKPDMGKKAKHKTQI 80 Query: 215 IKCSLNPEWNETFRFQLKESDKDRR-LSVEIWDWDLTSRNDFMGSLSFGIS 264 K +LNPE+NE F + +K SD ++ L + +WD+D+ ND++G GIS Sbjct: 81 KKKTLNPEFNEEFFYDIKHSDLAKKSLDISVWDYDIGKSNDYIGGCQLGIS 131 >4LG4-A nrPDB Length = 299 Score = 84.7 bits (208), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 53/202 (26%), Positives = 102/202 (50%), Gaps = 9/202 (4%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 F+ L LG+GS+G V + K + ++ A+K + + +Q+ E +++++ P Sbjct: 13 FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQ------CDSP 66 Query: 402 FLTQLHSCFQTMDRLYFVMEYVNGGDL--MYHIQQVGRFKEPHAVFYAAEIAIGLFFLQS 459 ++ + + + L+ VMEY G + + ++ ++ A + + GL +L Sbjct: 67 YVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLK-GLEYLHF 125 Query: 460 KGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYG 519 I+R++K N++L++EGH K+ADFG+ + T GTP ++APE+I Y Sbjct: 126 MRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYN 185 Query: 520 KSVDWWAFGVLLYEMLAGQAPF 541 D W+ G+ EM G+ P+ Sbjct: 186 CVADIWSLGITSIEMAEGKPPY 207 >6B2Q-A nrPDB Length = 317 Score = 84.3 bits (207), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 62/223 (27%), Positives = 99/223 (44%), Gaps = 14/223 (6%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 + ++ G G+V + AVK+LK + + +E E R A+ P Sbjct: 34 YRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHPG 93 Query: 402 FLT-------QLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGL 454 + Q++ +T Y VME VNG L +++ GR HA+ + L Sbjct: 94 IASVHDYGESQMNGEGRTA---YLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRAL 150 Query: 455 FFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVT-TKTFCGTPDYIAPEII 513 + G+++RD+K N+++ G +KI DFG+ K VT T GT YIAPE Sbjct: 151 QIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQA 210 Query: 514 AYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEH 556 + D ++ GV+ YE ++G+ PF G D M+H Sbjct: 211 LGHDASPASDVYSLGVVGYEAVSGKRPFAG---DGALTVAMKH 250 >3QGY-A nrPDB Length = 286 Score = 84.3 bits (207), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 57/217 (26%), Positives = 108/217 (49%), Gaps = 9/217 (4%) Query: 340 TDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK 399 ++ F+ +G G FG V L D++ A+K +K+ + +DD +E+ + + Sbjct: 27 SELTFVQEIGSGQFGLVHLGYWLNKDKV-AIKTIKEGSMSEDD-----FIEEAEVMMKLS 80 Query: 400 PPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQ-QVGRFKEPHAVFYAAEIAIGLFFLQ 458 P L QL+ + V E++ G L +++ Q G F + ++ G+ +L+ Sbjct: 81 HPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLE 140 Query: 459 SKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTP-DYIAPEIIAYQP 517 +I+RDL N ++ IK++DFGM + + D T+ T P + +PE+ ++ Sbjct: 141 EACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSR 200 Query: 518 YGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSI 553 Y D W+FGVL++E+ + G+ P+E E+ + I Sbjct: 201 YSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDI 237 >5HI2-A nrPDB Length = 283 Score = 84.0 bits (206), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 60/213 (28%), Positives = 102/213 (47%), Gaps = 18/213 (8%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 407 +G GSFG V + G AVK+L + + V L L Sbjct: 28 IGSGSFGTVYKGKWHGD---VAVKMLTPQ--------QLQAFKNEVGVLRKTRHVNILLF 76 Query: 408 SCFQTMDRLYFVMEYVNGGDLMYHIQQV-GRFKEPHAVFYAAEIAIGLFFLQSKGIIYRD 466 + T +L V ++ G L +H+ +F+ + A + A G+ +L +K II+RD Sbjct: 77 MGYSTKPQLAIVTQWCEGSSLYHHLHASETKFEMKKLIDIARQTARGMDYLHAKSIIHRD 136 Query: 467 LKLDNVMLDSEGHIKIADFGMCK-ENIWDGVTT-KTFCGTPDYIAPEIIAYQ---PYGKS 521 LK +N+ L + +KI DFG+ ++ W G + G+ ++APE+I Q PY Sbjct: 137 LKSNNIFLHEDNTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDSNPYSFQ 196 Query: 522 VDWWAFGVLLYEMLAGQAPFEG-EDEDELFQSI 553 D +AFG++LYE++ GQ P+ + D++ + + Sbjct: 197 SDVYAFGIVLYELMTGQLPYSNINNRDQIIEMV 229 >5KKR-C nrPDB Length = 395 Score = 84.0 bits (206), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 58/216 (26%), Positives = 104/216 (48%), Gaps = 10/216 (4%) Query: 337 MKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLAL 396 +K DF + LG G+ G V K + + A K++ ++ + ++ + + Sbjct: 65 LKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEI---KPAIRNQIIRELQVLH 121 Query: 397 PGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAI--GL 454 P++ + F + + ME+++GG L +++ GR P + IA+ GL Sbjct: 122 ECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRI--PEQILGKVSIAVIKGL 179 Query: 455 FFLQSK-GIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEII 513 +L+ K I++RD+K N++++S G IK+ DFG+ + I +F GT Y++PE + Sbjct: 180 TYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLI--DSMANSFVGTRSYMSPERL 237 Query: 514 AYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDEL 549 Y D W+ G+ L EM G+ P D EL Sbjct: 238 QGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKEL 273 >2CM5-A nrPDB Length = 166 Score = 84.0 bits (206), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 45/111 (40%), Positives = 66/111 (59%), Gaps = 3/111 (2%) Query: 157 ERRGRIYIQAHIDREV--LIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKT 214 E RG+I + + LIV + +L MD NG SDP+VKL L PD ++K KT+ Sbjct: 21 EERGKILVSLMYSTQQGGLIVGIIRCVHLAAMDANGYSDPFVKLWLKPDMGKKAKHKTQI 80 Query: 215 IKCSLNPEWNETFRFQLKESDKDRR-LSVEIWDWDLTSRNDFMGSLSFGIS 264 K +LNPE+NE F + +K SD ++ L + +WD+D+ ND++G GIS Sbjct: 81 KKKTLNPEFNEEFFYDIKHSDLAKKSLDISVWDYDIGKSNDYIGGCQLGIS 131 >3DAK-A nrPDB Length = 290 Score = 83.6 bits (205), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 50/155 (32%), Positives = 79/155 (50%), Gaps = 14/155 (9%) Query: 401 PFLTQLHSCFQTMDRLYFVMEYVNGG---DLMYHIQQVGRFK-----EPHAVFYAAEIAI 452 P + ++ F D L+ VM+ ++GG D++ HI G K E E+ Sbjct: 68 PNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLE 127 Query: 453 GLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCK-----ENIWDGVTTKTFCGTPDY 507 GL +L G I+RD+K N++L +G ++IADFG+ +I KTF GTP + Sbjct: 128 GLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCW 187 Query: 508 IAPEII-AYQPYGKSVDWWAFGVLLYEMLAGQAPF 541 +APE++ + Y D W+FG+ E+ G AP+ Sbjct: 188 MAPEVMEQVRGYDFKADIWSFGITAIELATGAAPY 222 >4FKD-A nrPDB Length = 65 Score = 83.6 bits (205), Expect = 3e-16, Method: Composition-based stats. Identities = 31/50 (62%), Positives = 39/50 (78%) Query: 102 HKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLC 151 H+FK++ Y SPTFC+HCG+LL+GL QG+KCD C MNVH RC V +LC Sbjct: 10 HRFKVYNYKSPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTKVANLC 59 Score = 59.7 bits (143), Expect = 4e-09, Method: Composition-based stats. Identities = 22/53 (41%), Positives = 28/53 (52%) Query: 34 VKNHKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSC 86 V +H+F +K PTFC HC +WG +QG +C C VH RC V C Sbjct: 7 VGSHRFKVYNYKSPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTKVANLC 59 >2DQ7-X nrPDB Length = 283 Score = 83.6 bits (205), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 61/210 (29%), Positives = 110/210 (52%), Gaps = 11/210 (5%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 407 LG G FG+V + G ++ A+K LK + + +E + K++ K L QL+ Sbjct: 17 LGNGQFGEVWMGTWNGNTKV-AIKTLKPGTMSPESFLEEAQIMKKL-----KHDKLVQLY 70 Query: 408 SCFQTMDRLYFVMEYVNGGDLMYHIQQ-VGR-FKEPHAVFYAAEIAIGLFFLQSKGIIYR 465 + + + +Y V EY+N G L+ ++ GR K P+ V AA++A G+ +++ I+R Sbjct: 71 AVV-SEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHR 129 Query: 466 DLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTP-DYIAPEIIAYQPYGKSVDW 524 DL+ N+++ + KIADFG+ + + T + P + APE Y + D Sbjct: 130 DLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV 189 Query: 525 WAFGVLLYEMLA-GQAPFEGEDEDELFQSI 553 W+FG+LL E++ G+ P+ G + E+ + + Sbjct: 190 WSFGILLTELVTKGRVPYPGMNNREVLEQV 219 >3EQC-A nrPDB Length = 360 Score = 83.2 bits (204), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 58/216 (26%), Positives = 104/216 (48%), Gaps = 10/216 (4%) Query: 337 MKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLAL 396 +K DF + LG G+ G V K + + A K++ ++ + ++ + + Sbjct: 30 LKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEI---KPAIRNQIIRELQVLH 86 Query: 397 PGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAI--GL 454 P++ + F + + ME+++GG L +++ GR P + IA+ GL Sbjct: 87 ECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRI--PEQILGKVSIAVIKGL 144 Query: 455 FFLQSK-GIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEII 513 +L+ K I++RD+K N++++S G IK+ DFG+ + I +F GT Y++PE + Sbjct: 145 TYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLI--DSMANSFVGTRSYMSPERL 202 Query: 514 AYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDEL 549 Y D W+ G+ L EM G+ P D EL Sbjct: 203 QGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKEL 238 >4IDT-A nrPDB Length = 356 Score = 83.2 bits (204), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 68/251 (27%), Positives = 114/251 (45%), Gaps = 32/251 (12%) Query: 308 AKIGQGTKAPEEKTANTISKFDNNGN--RDRMKLTDFNFL---------MVLGKGSFGKV 356 A G ++ P KT DN G +++K D+ + + LG+GSFG+V Sbjct: 37 AARGSRSREPSPKTE------DNEGVLLTEKLKPVDYEYREEVHWATHQLRLGRGSFGEV 90 Query: 357 MLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRL 416 E K T AVK ++ +V ++ + C + P + L+ + + Sbjct: 91 HRMEDKQTGFQCAVKKVRLEVFRAEELMACAGLTS---------PRIVPLYGAVREGPWV 141 Query: 417 YFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDS 476 ME + GG L +++ G E A++Y + GL +L S+ I++ D+K DNV+L S Sbjct: 142 NIFMELLEGGSLGQLVKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVKADNVLLSS 201 Query: 477 EG-HIKIADFGMCKENIWDG-----VTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVL 530 +G H + DFG DG +T GT ++APE++ + VD W+ + Sbjct: 202 DGSHAALCDFGHAVCLQPDGLGKDLLTGDYIPGTETHMAPEVVLGRSCDAKVDVWSSCCM 261 Query: 531 LYEMLAGQAPF 541 + ML G P+ Sbjct: 262 MLHMLNGCHPW 272 >3OZ6-A nrPDB Length = 388 Score = 83.2 bits (204), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 66/247 (26%), Positives = 112/247 (45%), Gaps = 27/247 (10%) Query: 332 GNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEK 391 G DR L + + LGKG++G V S + T E+ AVK + D D + T E Sbjct: 1 GRVDRHVLRKYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIF-DAFQNSTDAQRTFREI 59 Query: 392 RVLA-LPGKPPFLTQLHSCFQTMDR-LYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAE 449 +L L G + L+ DR +Y V +Y+ ++ + + + H + + Sbjct: 60 MILTELSGHENIVNLLNVLRADNDRDVYLVFDYMETD--LHAVIRANILEPVHKQYVVYQ 117 Query: 450 IAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCK---------ENIWDGVTTKT 500 + + +L S G+++RD+K N++L++E H+K+ADFG+ + NI + T Sbjct: 118 LIKVIKYLHSGGLLHRDMKPSNILLNAECHVKVADFGLSRSFVNIRRVTNNIPLSINENT 177 Query: 501 ------------FCGTPDYIAPEI-IAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDED 547 + T Y APEI + Y K +D W+ G +L E+L G+ F G Sbjct: 178 ENFDDDQPILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGKPIFPGSSTM 237 Query: 548 ELFQSIM 554 + I+ Sbjct: 238 NQLERII 244 >5G6V-A nrPDB Length = 324 Score = 82.8 bits (203), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 58/211 (27%), Positives = 99/211 (46%), Gaps = 12/211 (5%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 407 LG+G++ V + K TD L A+K ++ + ++ CT + + L K + LH Sbjct: 10 LGEGTYATVYKGKSKLTDNLVALKEIRLE---HEEGAPCTAIREVSLLKDLKHANIVTLH 66 Query: 408 SCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAV-FYAAEIAIGLFFLQSKGIIYRD 466 T L V EY++ DL ++ G H V + ++ GL + + +++RD Sbjct: 67 DIIHTEKSLTLVFEYLDK-DLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRD 125 Query: 467 LKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTF---CGTPDYIAPEI-IAYQPYGKSV 522 LK N++++ G +K+ADFG+ + + TKT+ T Y P+I + Y + Sbjct: 126 LKPQNLLINERGELKLADFGLARAK---SIPTKTYDNEVVTLWYRPPDILLGSTDYSTQI 182 Query: 523 DWWAFGVLLYEMLAGQAPFEGEDEDELFQSI 553 D W G + YEM G+ F G +E I Sbjct: 183 DMWGVGCIFYEMATGRPLFPGSTVEEQLHFI 213 >4EQM-A nrPDB Length = 294 Score = 82.4 bits (202), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 44/129 (34%), Positives = 68/129 (52%), Gaps = 1/129 (0%) Query: 417 YFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDS 476 Y VMEY+ G L +I+ G A+ + +I G+ I++RD+K N+++DS Sbjct: 87 YLVMEYIEGPTLSEYIESHGPLSVDTAINFTNQILDGIKHAHDMRIVHRDIKPQNILIDS 146 Query: 477 EGHIKIADFGMCKENIWDGVT-TKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEML 535 +KI DFG+ K +T T GT Y +PE + + D ++ G++LYEML Sbjct: 147 NKTLKIFDFGIAKALSETSLTQTNHVLGTVQYFSPEQAKGEATDECTDIYSIGIVLYEML 206 Query: 536 AGQAPFEGE 544 G+ PF GE Sbjct: 207 VGEPPFNGE 215 >3RPB-A nrPDB Length = 140 Score = 82.4 bits (202), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 44/109 (40%), Positives = 65/109 (59%), Gaps = 3/109 (2%) Query: 159 RGRIYIQAHIDREV--LIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIK 216 RG+I + + LIV + +L MD NG SDP+VKL L PD ++K KT+ K Sbjct: 1 RGKILVSLMYSTQQGGLIVGIIRCVHLAAMDANGYSDPFVKLWLKPDMGKKAKHKTQIKK 60 Query: 217 CSLNPEWNETFRFQLKESDKDRR-LSVEIWDWDLTSRNDFMGSLSFGIS 264 +LNPE+NE F + +K SD ++ L + +WD+D+ ND++G GIS Sbjct: 61 KTLNPEFNEEFFYDIKHSDLAKKSLDISVWDYDIGKSNDYIGGCQLGIS 109 >3QA8-A nrPDB Length = 676 Score = 82.0 bits (201), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 61/205 (29%), Positives = 100/205 (48%), Gaps = 14/205 (6%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLT--Q 405 LG G FG V+ + T E A+K ++++ ++ + C +E +++ P ++ + Sbjct: 22 LGTGGFGYVLRWIHQDTGEQVAIKQCRQELSPKNRERWC--LEIQIMKKLNHPNVVSARE 79 Query: 406 LHSCFQTM---DRLYFVMEYVNGGDLMYHIQQVGR---FKEPHAVFYAAEIAIGLFFLQS 459 + Q + D MEY GGDL ++ Q KE ++I+ L +L Sbjct: 80 VPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGPIRTLLSDISSALRYLHE 139 Query: 460 KGIIYRDLKLDNVMLDSEGHI---KIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQ 516 II+RDLK +N++L KI D G KE + G F GT Y+APE++ + Sbjct: 140 NRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKE-LDQGELCTEFVGTLQYLAPELLEQK 198 Query: 517 PYGKSVDWWAFGVLLYEMLAGQAPF 541 Y +VD+W+FG L +E + G PF Sbjct: 199 KYTVTVDYWSFGTLAFECITGFRPF 223 >3ORP-A nrPDB Length = 311 Score = 82.0 bits (201), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 56/189 (29%), Positives = 88/189 (46%), Gaps = 15/189 (7%) Query: 417 YFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDS 476 Y VMEYV+G L + G A+ A+ L F GII+RD+K N+M+ + Sbjct: 92 YIVMEYVDGVTLRDIVHTEGPMTPKRAIEVIADACQALNFSHQNGIIHRDVKPANIMISA 151 Query: 477 EGHIKIADFGMCKENIWDG---VTTKTFCGTPDYIAPEIIAYQPYGKSVDW----WAFGV 529 +K+ DFG+ + G T GT Y++PE Q G SVD ++ G Sbjct: 152 TNAVKVMDFGIARAIADSGNSVTQTAAVIGTAQYLSPE----QARGDSVDARSDVYSLGC 207 Query: 530 LLYEMLAGQAPFEGEDEDEL-FQSIMEHNV---AYPKSMSKEAVAICKGLMTKHPGKRLG 585 +LYE+L G+ PF G+ + +Q + E + A + +S + A+ + K+P R Sbjct: 208 VLYEVLTGEPPFTGDSPVSVAYQHVREDPIPPSARHEGLSADLDAVVLKALAKNPENRYQ 267 Query: 586 CGPEGERDI 594 E D+ Sbjct: 268 TAAEMRADL 276 >5DBX-A nrPDB Length = 328 Score = 81.6 bits (200), Expect = 9e-16, Method: Compositional matrix adjust. Identities = 51/155 (32%), Positives = 80/155 (51%), Gaps = 14/155 (9%) Query: 401 PFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQ-VGRFKEPHAVFYAAEIAI------- 452 P + ++ F D L+ VM+ ++GG ++ I+ V R + + V A IA Sbjct: 69 PNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLE 128 Query: 453 GLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTT-----KTFCGTPDY 507 GL +L G I+RDLK N++L +G ++IADFG+ G T K F GTP + Sbjct: 129 GLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKDFVGTPCW 188 Query: 508 IAPEII-AYQPYGKSVDWWAFGVLLYEMLAGQAPF 541 +APE++ + Y D W+FG+ E+ G AP+ Sbjct: 189 MAPEVMEQVRGYDFKADMWSFGITAIELATGAAPY 223 >2YUU-A nrPDB Length = 83 Score = 81.6 bits (200), Expect = 9e-16, Method: Composition-based stats. Identities = 33/75 (44%), Positives = 46/75 (61%), Gaps = 6/75 (8%) Query: 27 RQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSC 86 +Q +H +KNH+F A FF QPTFCS C DF+WG KQG++C+ C +HK+C + + C Sbjct: 8 KQAKIHYIKNHEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRC 67 Query: 87 PGA------DKGPAS 95 G GP+S Sbjct: 68 TGTAANSRDTSGPSS 82 Score = 47.4 bits (111), Expect = 2e-05, Method: Composition-based stats. Identities = 21/58 (36%), Positives = 29/58 (50%), Gaps = 1/58 (1%) Query: 102 HKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLC-GTDHTER 158 H+F + PTFC C ++GL QG KC C +HK+C+ + C GT R Sbjct: 18 HEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSR 75 >5HIE-A nrPDB Length = 302 Score = 81.6 bits (200), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 59/201 (29%), Positives = 97/201 (48%), Gaps = 17/201 (8%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 407 +G GSFG V + G AVK+L + + V L L Sbjct: 44 IGSGSFGTVYKGKWHGD---VAVKMLTPQ--------QLQAFKNEVGVLRKTRHVNILLF 92 Query: 408 SCFQTMDRLYFVMEYVNGGDLMYHIQQV-GRFKEPHAVFYAAEIAIGLFFLQSKGIIYRD 466 + T +L V ++ G L +H+ + +F+ + A + A G+ +L +K II+RD Sbjct: 93 MGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRD 152 Query: 467 LKLDNVMLDSEGHIKIADFGMCK-ENIWDGVTT-KTFCGTPDYIAPEIIAYQ---PYGKS 521 LK +N+ L + +KI DFG+ ++ W G + G+ ++APE+I Q PY Sbjct: 153 LKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQ 212 Query: 522 VDWWAFGVLLYEMLAGQAPFE 542 D +AFG++LYE++ GQ P+ Sbjct: 213 SDVYAFGIVLYELMTGQLPYS 233 >4G3E-A nrPDB Length = 352 Score = 81.6 bits (200), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 58/200 (29%), Positives = 99/200 (49%), Gaps = 15/200 (7%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 407 +G+GSFG+V + K T AVK ++ +V ++ V C + P + L+ Sbjct: 82 VGRGSFGEVHRMKDKQTGFQCAVKKVRLEVFRVEELVACAGLSS---------PRIVPLY 132 Query: 408 SCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDL 467 + + ME + GG L I+Q+G E A++Y + GL +L ++ I++ D+ Sbjct: 133 GAVREGPWVNIFMELLEGGSLGQLIKQMGCLPEDRALYYLGQALEGLEYLHTRRILHGDV 192 Query: 468 KLDNVMLDSEG-HIKIADFG--MCKENIWDG---VTTKTFCGTPDYIAPEIIAYQPYGKS 521 K DNV+L S+G + DFG +C + G +T GT ++APE++ +P Sbjct: 193 KADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAPEVVMGKPCDAK 252 Query: 522 VDWWAFGVLLYEMLAGQAPF 541 VD W+ ++ ML G P+ Sbjct: 253 VDIWSSCCMMLHMLNGCHPW 272 >1S9I-A nrPDB Length = 354 Score = 81.6 bits (200), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 56/216 (25%), Positives = 104/216 (48%), Gaps = 10/216 (4%) Query: 337 MKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLAL 396 +K DF + LG G+ G V + + + + A K++ ++ + ++ + + Sbjct: 13 LKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEI---KPAIRNQIIRELQVLH 69 Query: 397 PGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAI--GL 454 P++ + F + + ME+++GG L +++ R P + IA+ GL Sbjct: 70 ECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRI--PEEILGKVSIAVLRGL 127 Query: 455 FFLQSK-GIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEII 513 +L+ K I++RD+K N++++S G IK+ DFG+ + I +F GT Y+APE + Sbjct: 128 AYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS--MANSFVGTRSYMAPERL 185 Query: 514 AYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDEL 549 Y D W+ G+ L E+ G+ P D EL Sbjct: 186 QGTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKEL 221 >6GU6-A nrPDB Length = 302 Score = 80.1 bits (196), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 57/221 (25%), Positives = 113/221 (51%), Gaps = 14/221 (6%) Query: 339 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 398 + D+ + +G+G++G V K T ++ A+K ++ + +++ V T + + L Sbjct: 6 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLES--EEEGVPSTAIREISLLKEL 63 Query: 399 KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQV--GRFKEPHAV-FYAAEIAIGLF 455 + P + L RLY + E+++ DL ++ + G++ + V Y +I G+ Sbjct: 64 RHPNIVSLQDVLMQDSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIV 122 Query: 456 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCG---TPDYIAPEI 512 F S+ +++RDLK N+++D +G IK+ADFG+ + G+ + + T Y +PE+ Sbjct: 123 FCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF---GIPIRVYTHEVVTLWYRSPEV 179 Query: 513 -IAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDE-DELFQ 551 + Y VD W+ G + E+ + F G+ E D+LF+ Sbjct: 180 LLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFR 220 >3OMV-A nrPDB Length = 307 Score = 80.1 bits (196), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 59/200 (29%), Positives = 97/200 (48%), Gaps = 12/200 (6%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 407 +G GSFG V + G AVKILK V+ + V L L Sbjct: 44 IGSGSFGTVYKGKWHGD---VAVKILK---VVDPTPEQFQAFRNEVAVLRKTRHVNILLF 97 Query: 408 SCFQTMDRLYFVMEYVNGGDLMYHIQ-QVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRD 466 + T D L V ++ G L H+ Q +F+ + A + A G+ +L +K II+RD Sbjct: 98 MGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRD 157 Query: 467 LKLDNVMLDSEGHIKIADFGMCK-ENIWDGV-TTKTFCGTPDYIAPEIIAYQ---PYGKS 521 +K +N+ L +KI DFG+ ++ W G + G+ ++APE+I Q P+ Sbjct: 158 MKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQ 217 Query: 522 VDWWAFGVLLYEMLAGQAPF 541 D +++G++LYE++ G+ P+ Sbjct: 218 SDVYSYGIVLYELMTGELPY 237 >2H8H-A nrPDB Length = 535 Score = 80.1 bits (196), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 57/210 (27%), Positives = 108/210 (51%), Gaps = 11/210 (5%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 407 LG+G FG+V + GT + A+K LK + + ++ V K++ + L QL+ Sbjct: 275 LGQGCFGEVWMGTWNGTTRV-AIKTLKPGTMSPEAFLQEAQVMKKL-----RHEKLVQLY 328 Query: 408 SCFQTMDRLYFVMEYVNGGDLMYHIQ-QVGRF-KEPHAVFYAAEIAIGLFFLQSKGIIYR 465 + + + +Y V EY++ G L+ ++ + G++ + P V AA+IA G+ +++ ++R Sbjct: 329 AVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHR 387 Query: 466 DLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTP-DYIAPEIIAYQPYGKSVDW 524 DL+ N+++ K+ADFG+ + + T + P + APE Y + D Sbjct: 388 DLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV 447 Query: 525 WAFGVLLYEMLA-GQAPFEGEDEDELFQSI 553 W+FG+LL E+ G+ P+ G E+ + Sbjct: 448 WSFGILLTELTTKGRVPYPGMVNREVLDQV 477 >1K9A-A nrPDB Length = 450 Score = 80.1 bits (196), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 63/245 (25%), Positives = 114/245 (46%), Gaps = 24/245 (9%) Query: 301 LRQKFERAKIGQGTKAPEEKTANTISKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSE 360 L + + K+ +GT A +++ F +G MK + L +GKG FG VML + Sbjct: 163 LCTRLIKPKVMEGTVAAQDE-------FYRSGWALNMK--ELKLLQTIGKGEFGDVMLGD 213 Query: 361 RKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVM 420 +G AVK +K D Q + E V+ + L + LY V Sbjct: 214 YRGNK--VAVKCIKNDATAQ-----AFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVT 266 Query: 421 EYVNGGDLMYHIQQVGR--FKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEG 478 EY+ G L+ +++ GR + ++ ++ + +L+ ++RDL NV++ + Sbjct: 267 EYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDN 326 Query: 479 HIKIADFGMCKENIWDGVTTKTFCGTP-DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA- 536 K++DFG+ KE +T+ P + APE + + + D W+FG+LL+E+ + Sbjct: 327 VAKVSDFGLTKE----ASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSF 382 Query: 537 GQAPF 541 G+ P+ Sbjct: 383 GRVPY 387 >4AN9-A nrPDB Length = 301 Score = 79.7 bits (195), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 70/278 (25%), Positives = 128/278 (46%), Gaps = 17/278 (6%) Query: 337 MKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLAL 396 +K DF + LG G+ G V K + + A K++ ++ + ++ + + Sbjct: 6 LKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEI---KPAIRNQIIRELQVLH 62 Query: 397 PGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAI--GL 454 P++ + F + + ME+++GG L +++ GR P + IA+ GL Sbjct: 63 ECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRI--PEQILGKVSIAVIKGL 120 Query: 455 FFLQSK-GIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEII 513 +L+ K I++RD+K N++++S G IK+ DFG+ + I + F GT Y++PE + Sbjct: 121 TYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDE--MANEFVGTRSYMSPERL 178 Query: 514 AYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIM-EHNVAYPKSM-SKEAVAI 571 Y D W+ G+ L EM G+ P EL I+ E P ++ S E Sbjct: 179 QGTHYSVQSDIWSMGLSLVEMAVGRYPRPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDF 238 Query: 572 CKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLE 609 + K+P +R + + HAF + D E+++ Sbjct: 239 VNKCLIKNPAERADL-----KQLMVHAFIKRSDAEEVD 271 >6F3F-A nrPDB Length = 455 Score = 79.7 bits (195), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 57/210 (27%), Positives = 108/210 (51%), Gaps = 11/210 (5%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 407 LG+G FG+V + GT + A+K LK + + ++ V K++ + L QL+ Sbjct: 195 LGQGCFGEVWMGTWNGTTRV-AIKTLKPGTMSPEAFLQEAQVMKKL-----RHEKLVQLY 248 Query: 408 SCFQTMDRLYFVMEYVNGGDLMYHIQ-QVGRF-KEPHAVFYAAEIAIGLFFLQSKGIIYR 465 + + + +Y V EY+N G L+ ++ + G++ + P V +A+IA G+ +++ ++R Sbjct: 249 AVV-SEEPIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVERMNYVHR 307 Query: 466 DLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTP-DYIAPEIIAYQPYGKSVDW 524 DL+ N+++ K+ADFG+ + + T + P + APE Y + D Sbjct: 308 DLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV 367 Query: 525 WAFGVLLYEMLA-GQAPFEGEDEDELFQSI 553 W+FG+LL E+ G+ P+ G E+ + Sbjct: 368 WSFGILLTELTTKGRVPYPGMVNREVLDQV 397 >4YFF-A nrPDB Length = 311 Score = 79.3 bits (194), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 54/211 (25%), Positives = 108/211 (51%), Gaps = 9/211 (4%) Query: 337 MKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLAL 396 ++L++ F ++G GSFGKV + + +++ A+K + + DV+ E +L Sbjct: 39 LQLSEIEFHEIIGSGSFGKVY--KGRCRNKIVAIKRYRANTYCSKSDVDMFCREVSILCQ 96 Query: 397 PGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHA-VFYAAEIAIGLF 455 P + + +C + V +Y++GG L + + R + + + A ++A G+ Sbjct: 97 LNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGME 156 Query: 456 FLQ--SKGIIYRDLKLDNVMLDSEGHIKIADFGMCK--ENIWDGVTTKTFCGTPDYIAPE 511 +L ++ II+RDL N++L +GH +ADFG + +++ + TK G ++APE Sbjct: 157 YLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQ-PGNLRWMAPE 215 Query: 512 IIAY-QPYGKSVDWWAFGVLLYEMLAGQAPF 541 + Y D +++ + L+E+L G+ PF Sbjct: 216 VFTQCTRYTIKADVFSYALCLWEILTGEIPF 246 >4BBM-A nrPDB Length = 331 Score = 79.3 bits (194), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 70/227 (30%), Positives = 105/227 (46%), Gaps = 34/227 (14%) Query: 345 LMVLGKGSFGKVMLSERKGTDELYAVK-ILKKDVVIQDDDV--ECTMVEKRVLALPGKPP 401 L ++G+GS+G VM K T + A+K L+ D DD + + M E ++L Sbjct: 30 LGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESD----DDKMVKKIAMREIKLLKQLRHEN 85 Query: 402 FLTQLHSCFQTMDRLYFVMEYV------------NGGDLMYHIQQVGRFKEPHAVFYAAE 449 + L C + R Y V E+V NG D Y + Q Y + Sbjct: 86 LVNLLEVC-KKKKRWYLVFEFVDHTILDDLELFPNGLD--YQVVQK----------YLFQ 132 Query: 450 IAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIA 509 I G+ F S II+RD+K +N+++ G +K+ DFG + G T Y A Sbjct: 133 IINGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYDDEVATRWYRA 192 Query: 510 PEIIAYQ-PYGKSVDWWAFGVLLYEMLAGQAPFEGE-DEDELFQSIM 554 PE++ YGK+VD WA G L+ EM G+ F G+ D D+L+ +M Sbjct: 193 PELLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMM 239 >4HVI-A nrPDB Length = 314 Score = 79.3 bits (194), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 63/212 (29%), Positives = 96/212 (45%), Gaps = 30/212 (14%) Query: 342 FNFLMVLGKGSFGKVMLSERK----GTDELYAVKILKKDVVIQDDDVECTMVEKRVLALP 397 ++ LGKG+FG V L T L AVK L+ Q D + + Sbjct: 12 LKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREI--------- 62 Query: 398 GKPPFLTQLHSCFQTMDR----------LYFVMEYVNGGDLMYHIQQ-VGRFKEPHAVFY 446 L LHS F R L VMEY+ G L +Q+ R + Y Sbjct: 63 ---QILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLY 119 Query: 447 AAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDG---VTTKTFCG 503 +++I G+ +L S+ ++RDL N++++SE H+KIADFG+ K D V + Sbjct: 120 SSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQS 179 Query: 504 TPDYIAPEIIAYQPYGKSVDWWAFGVLLYEML 535 + APE ++ + + D W+FGV+LYE+ Sbjct: 180 PIFWYAPESLSDNIFSRQSDVWSFGVVLYELF 211 >5D7A-A nrPDB Length = 308 Score = 79.3 bits (194), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 61/220 (27%), Positives = 98/220 (44%), Gaps = 31/220 (14%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDD---VECTMVEK----RVL 394 F + ++G G++G+V T +L A+K++ DV +++ E M++K R + Sbjct: 19 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVM--DVTGDEEEEIKQEINMLKKYSHHRNI 76 Query: 395 A------LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQV--GRFKEPHAVFY 446 A + PP + D+L+ VME+ G + I+ KE + Sbjct: 77 ATYYGAFIKKNPPGMD---------DQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYI 127 Query: 447 AAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPD 506 EI GL L +I+RD+K NV+L +K+ DFG+ + TF GTP Sbjct: 128 CREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPY 187 Query: 507 YIAPEIIAYQ-----PYGKSVDWWAFGVLLYEMLAGQAPF 541 ++APE+IA Y D W+ G+ EM G P Sbjct: 188 WMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPL 227 >3HKO-A nrPDB Length = 345 Score = 79.3 bits (194), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 65/265 (24%), Positives = 116/265 (43%), Gaps = 55/265 (20%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVV--IQDDDVECTMVEKRVLALPGKPPFLTQ 405 +G+GS+G V ++ T + A+KI+ K+ + I DVE E R++ P + + Sbjct: 34 IGQGSYGVVRVAIENQTRAIRAIKIMNKNKIRQINPKDVERIKTEVRLMKKLHHPN-IAR 92 Query: 406 LHSCFQTMDRLYFVMEYVNGGDLMYHIQ-------------------------------- 433 L+ ++ + VME +GG L+ + Sbjct: 93 LYEVYEDEQYICLVMELCHGGHLLDKLNVFIDDSTGKCAMDVVKTQICPCPECNEEAING 152 Query: 434 QVGRFKEPHAVF--------YAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEG--HIKIA 483 + F+E +I L +L ++GI +RD+K +N + + IK+ Sbjct: 153 SIHGFRESLDFVQREKLISNIMRQIFSALHYLHNQGICHRDIKPENFLFSTNKSFEIKLV 212 Query: 484 DFGMCKE------NIWDGVTTKTFCGTPDYIAPEII--AYQPYGKSVDWWAFGVLLYEML 535 DFG+ KE + G+TTK GTP ++APE++ + YG D W+ GVLL+ +L Sbjct: 213 DFGLSKEFYKLNNGEYYGMTTKA--GTPYFVAPEVLNTTNESYGPKCDAWSAGVLLHLLL 270 Query: 536 AGQAPFEGEDEDELFQSIMEHNVAY 560 G PF G ++ + ++ + + Sbjct: 271 MGAVPFPGVNDADTISQVLNKKLCF 295 >1BYG-A nrPDB Length = 278 Score = 79.0 bits (193), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 54/209 (25%), Positives = 99/209 (47%), Gaps = 15/209 (7%) Query: 337 MKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLAL 396 + + + L +GKG FG VML + +G AVK +K D Q + E V+ Sbjct: 18 LNMKELKLLQTIGKGEFGDVMLGDYRGNK--VAVKCIKNDATAQ-----AFLAEASVMTQ 70 Query: 397 PGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR--FKEPHAVFYAAEIAIGL 454 + L + LY V EY+ G L+ +++ GR + ++ ++ + Sbjct: 71 LRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAM 130 Query: 455 FFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTP-DYIAPEII 513 +L+ ++RDL NV++ + K++DFG+ KE +T+ P + APE + Sbjct: 131 EYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKE----ASSTQDTGKLPVKWTAPEAL 186 Query: 514 AYQPYGKSVDWWAFGVLLYEMLA-GQAPF 541 + + D W+FG+LL+E+ + G+ P+ Sbjct: 187 REKKFSTKSDVWSFGILLWEIYSFGRVPY 215 >4NEU-A nrPDB Length = 333 Score = 79.0 bits (193), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 64/233 (27%), Positives = 111/233 (47%), Gaps = 24/233 (10%) Query: 329 DNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTM 388 D + N +MK +DF L G FGKV L + + + K I+ ++ + Sbjct: 13 DMSLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNE---AL 69 Query: 389 VEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAV--FY 446 +E+ + + + +L + VMEY+ G+LM+ ++ P +V Sbjct: 70 LEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLK--AEMSTPLSVKGRI 127 Query: 447 AAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGV---------- 496 EI G+ +L KG+I++DLK +N+++D++ HIKIAD G+ +W + Sbjct: 128 ILEIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELRE 187 Query: 497 ---TTKTFCGTPDYIAPEI---IAYQPYGKSVDWWAFGVLLYEMLAGQAPFEG 543 T K GT Y+APE + +P KS D ++F V+L+ + A + P+E Sbjct: 188 VDGTAKKNGGTLYYMAPEHLNDVNAKPTEKS-DVYSFAVVLWAIFANKEPYEN 239 >5HVK-A nrPDB Length = 315 Score = 78.6 bits (192), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 54/205 (26%), Positives = 102/205 (49%), Gaps = 19/205 (9%) Query: 347 VLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQL 406 VLGKG FG+ + + T E V ++K+ + ++ + E +V+ P L + Sbjct: 21 VLGKGCFGQAIKVTHRETGE---VMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFI 77 Query: 407 HSCFQTMDRLYFVMEYVNGGDLMYHIQQV-GRFKEPHAVFYAAEIAIGLFFLQSKGIIYR 465 ++ RL F+ EY+ GG L I+ + ++ V +A +IA G+ +L S II+R Sbjct: 78 GVLYKD-KRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHR 136 Query: 466 DLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTK--------------TFCGTPDYIAPE 511 +L N ++ ++ +ADFG+ + + + + T G P ++APE Sbjct: 137 NLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPE 196 Query: 512 IIAYQPYGKSVDWWAFGVLLYEMLA 536 +I + Y + VD ++FG++L E++ Sbjct: 197 MINGRSYDEKVDVFSFGIVLCEIIG 221 >2WQN-A nrPDB Length = 310 Score = 78.6 bits (192), Expect = 9e-15, Method: Compositional matrix adjust. Identities = 57/213 (26%), Positives = 97/213 (45%), Gaps = 11/213 (5%) Query: 339 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVI---QDDDVECTMVEKRVLA 395 L +F +G+G F +V + L V + K V I D +++ L Sbjct: 31 LANFRIEKKIGRGQFSEVY----RAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLL 86 Query: 396 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDL---MYHIQQVGRFKEPHAVF-YAAEIA 451 P + + ++ F + L V+E + GDL + H ++ R V+ Y ++ Sbjct: 87 KQLNHPNVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLC 146 Query: 452 IGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPE 511 L + S+ +++RD+K NV + + G +K+ D G+ + + GTP Y++PE Sbjct: 147 SALEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPE 206 Query: 512 IIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGE 544 I Y D W+ G LLYEM A Q+PF G+ Sbjct: 207 RIHENGYNFKSDIWSLGCLLYEMAALQSPFYGD 239 >3A4O-X nrPDB Length = 286 Score = 78.2 bits (191), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 56/210 (26%), Positives = 107/210 (50%), Gaps = 10/210 (4%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 407 LG G FG+V + + ++ AVK LK + V+ + E ++ L +L+ Sbjct: 21 LGAGQFGEVWMGYYNNSTKV-AVKTLKPGTM----SVQAFLEEANLMKTLQHDK-LVRLY 74 Query: 408 SCFQTMDRLYFVMEYVNGGDLMYHIQ--QVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYR 465 + + +Y + EY+ G L+ ++ + G+ P + ++A+IA G+ +++ K I+R Sbjct: 75 AVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHR 134 Query: 466 DLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTP-DYIAPEIIAYQPYGKSVDW 524 DL+ NV++ KIADFG+ + + T + P + APE I + + D Sbjct: 135 DLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDV 194 Query: 525 WAFGVLLYEMLA-GQAPFEGEDEDELFQSI 553 W+FG+LLYE++ G+ P+ G ++ ++ Sbjct: 195 WSFGILLYEIVTYGKIPYPGRTNADVMTAL 224 >3CJF-A nrPDB Length = 309 Score = 77.8 bits (190), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 68/238 (28%), Positives = 114/238 (47%), Gaps = 28/238 (11%) Query: 334 RDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDEL-----YAVKILKKDVVIQDDDVECTM 388 RDR+ L LG+G+FG+V+ ++ G D+ AVK+LK+ + M Sbjct: 26 RDRLNLGK-----PLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEH--RALM 78 Query: 389 VEKRVLALPGKP-PFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEP------ 441 E ++L G + L +C + L ++E+ G+L +++ P Sbjct: 79 SELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKDLYK 138 Query: 442 ------HAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWD- 494 H + Y+ ++A G+ FL S+ I+RDL N++L + +KI DFG+ ++ D Sbjct: 139 DFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDP 198 Query: 495 GVTTKTFCGTP-DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELF 550 K P ++APE I + Y D W+FGVLL+E+ + G +P+ G DE F Sbjct: 199 DYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEF 256 >5UE8-A nrPDB Length = 961 Score = 77.8 bits (190), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 66/262 (25%), Positives = 106/262 (40%), Gaps = 51/262 (19%) Query: 37 HKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSC-----PGADK 91 H F PT+C C +WG +QG +C C H++C + + C + K Sbjct: 39 HNFEVWTATTPTYCYECEGLLWGIARQGMRCTECGVKCHEKCQDLLNADCLQRAAEKSSK 98 Query: 92 GPASDDPRS-----KHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMN 146 A D ++ K + KI + P + L+ + T M K+ V++ Sbjct: 99 HGAEDRTQNIIMVLKDRMKIRERNKPEIFE----LIQEVFAVTKSAHTQQMKAVKQSVLD 154 Query: 147 VPSLCGTDHTERRGRIYIQAHIDREVLIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKS 206 GT + + + V A+ L D G SDPYV +++ Sbjct: 155 -----GTSKWSAK-------------ISITVVCAQGLQAKDKTGSSDPYVTVQV-----G 191 Query: 207 ESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDW--DLTSR---------NDF 255 ++K++TKTI +LNP W E F F+ S R+ V +WD D+ SR +DF Sbjct: 192 KTKKRTKTIYGNLNPVWEENFHFECHNSSD--RIKVRVWDEDDDIKSRVKQRFKRESDDF 249 Query: 256 MGSLSFGISELQKAGVDGWFKL 277 +G + L +D W+ L Sbjct: 250 LGQTIIEVRTL-SGEMDVWYNL 270 >3C1X-A nrPDB Length = 373 Score = 77.8 bits (190), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 63/211 (29%), Positives = 101/211 (47%), Gaps = 20/211 (9%) Query: 343 NFLMVLGKGSFGKV---MLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK 399 +F V+G+G FG V L + G AVK L + + +V + E ++ Sbjct: 92 HFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNR--ITDIGEVSQFLTEGIIMKDFSH 149 Query: 400 PPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPH------AVFYAAEIAIG 453 P L+ L C ++ V+ Y+ GDL I+ E H + + ++A G Sbjct: 150 PNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRN-----ETHNPTVKDLIGFGLQVAKG 204 Query: 454 LFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENI---WDGVTTKTFCGTP-DYIA 509 + FL SK ++RDL N MLD + +K+ADFG+ ++ +D V KT P ++A Sbjct: 205 MKFLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEFDSVHNKTGAKLPVKWMA 264 Query: 510 PEIIAYQPYGKSVDWWAFGVLLYEMLAGQAP 540 E + Q + D W+FGVLL+E++ AP Sbjct: 265 LESLQTQKFTTKSDVWSFGVLLWELMTRGAP 295 >5TOS-A nrPDB Length = 395 Score = 77.8 bits (190), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 63/227 (27%), Positives = 108/227 (47%), Gaps = 23/227 (10%) Query: 335 DRMKLTDFNFL--MVLGKGSFGKV---------MLSERKGTDELYAVKILKKDVVIQDDD 383 + +KL NF V+G+G FG V + + GT + AVK L ++ + Sbjct: 58 NELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHRE 117 Query: 384 VECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHA 443 + E L P + + C + RL V E++ G L H+ + G + +P Sbjct: 118 ---WLTEINYLGQLSHPNLVKLIGYCLEDEHRL-LVYEFMQKGSLENHLFRRGAYFKPLP 173 Query: 444 VFYAAEIAI----GLFFLQSK--GIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVT 497 F +A+ GL FL S +IYRD+K N++LD++ + K++DFG+ ++ ++ Sbjct: 174 WFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLS 233 Query: 498 --TKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFE 542 + GT Y APE ++ D ++FGVLL E+L+G+ + Sbjct: 234 YVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALD 280 >2HK5-A nrPDB Length = 270 Score = 77.4 bits (189), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 57/210 (27%), Positives = 108/210 (51%), Gaps = 11/210 (5%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 407 LG G FG+V ++ ++ AVK +K + VE + E V+ L +LH Sbjct: 23 LGAGQFGEVWMATYNKHTKV-AVKTMKPGSM----SVEAFLAEANVMKTLQHDK-LVKLH 76 Query: 408 SCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEP--HAVFYAAEIAIGLFFLQSKGIIYR 465 + T + +Y + E++ G L+ ++ K+P + ++A+IA G+ F++ + I+R Sbjct: 77 AVV-TKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHR 135 Query: 466 DLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTP-DYIAPEIIAYQPYGKSVDW 524 DL+ N+++ + KIADFG+ + + T + P + APE I + + D Sbjct: 136 DLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDV 195 Query: 525 WAFGVLLYEMLA-GQAPFEGEDEDELFQSI 553 W+FG+LL E++ G+ P+ G E+ +++ Sbjct: 196 WSFGILLMEIVTYGRIPYPGMSNPEVIRAL 225 >3BEA-A nrPDB Length = 333 Score = 77.4 bits (189), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 71/269 (26%), Positives = 122/269 (45%), Gaps = 28/269 (10%) Query: 340 TDFNFLMVLGKGSFGKVMLSERKGTDE-----LYAVKILKKDVVIQDDDVECTMVEKRVL 394 + F LG G+FGKV+ + G + AVK+LK D+ E M E +++ Sbjct: 46 NNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTA--HADEKEALMSELKIM 103 Query: 395 ALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVF--------- 445 + G+ + L + + EY GDL+ +++ R E F Sbjct: 104 SHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKSRVLETDPAFAIANSTLST 163 Query: 446 -----YAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHI-KIADFGMCKENIWDG-VTT 498 +++++A G+ FL SK I+RD+ NV+L + GH+ KI DFG+ ++ + D Sbjct: 164 RDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLL-TNGHVAKIGDFGLARDIMNDSNYIV 222 Query: 499 KTFCGTP-DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIME- 555 K P ++APE I Y D W++G+LL+E+ + G P+ G + F +++ Sbjct: 223 KGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKD 282 Query: 556 -HNVAYPKSMSKEAVAICKGLMTKHPGKR 583 + +A P K +I + P R Sbjct: 283 GYQMAQPAFAPKNIYSIMQACWALEPTHR 311 >2CHD-A nrPDB Length = 142 Score = 77.0 bits (188), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 40/101 (39%), Positives = 59/101 (58%), Gaps = 2/101 (1%) Query: 169 DREVLIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFR 228 D L + AK L PMD NGL+DPYVKL L+P +K +TKT++ + NP WNET + Sbjct: 27 DNSNLQCTIIRAKGLKPMDSNGLADPYVKLHLLPGASKSNKLRTKTLRNTRNPVWNETLQ 86 Query: 229 FQ-LKESDKDRR-LSVEIWDWDLTSRNDFMGSLSFGISELQ 267 + + E D R+ L + + D D N+F+G F + +L+ Sbjct: 87 YHGITEEDMQRKTLRISVCDEDKFGHNEFIGETRFSLKKLK 127 >5TUR-A nrPDB Length = 404 Score = 77.0 bits (188), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 64/251 (25%), Positives = 116/251 (46%), Gaps = 29/251 (11%) Query: 347 VLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDV--------ECTMVEKRVLALPG 398 +LG G FG V R + A+K ++KD + ++ E +++K G Sbjct: 134 LLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSG 193 Query: 399 KPPFLTQLHSCFQTMDRLYFVMEYVNG-GDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFL 457 + +L F+ D ++E DL I + G +E A + ++ + Sbjct: 194 ----VIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHC 249 Query: 458 QSKGIIYRDLKLDNVMLD-SEGHIKIADFG---MCKENIWDGVTTKTFCGTPDYIAPEII 513 + G+++RD+K +N+++D + G +K+ DFG + K+ ++ F GT Y PE I Sbjct: 250 HNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVY-----TDFDGTRVYSPPEWI 304 Query: 514 AYQPY-GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAIC 572 Y Y G+S W+ G+LLY+M+ G PFE ++E I+ V + + +S E + Sbjct: 305 RYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE------IIRGQVFFRQRVSSECQHLI 358 Query: 573 KGLMTKHPGKR 583 + + P R Sbjct: 359 RWCLALRPSDR 369 >1AD5-A nrPDB Length = 438 Score = 77.0 bits (188), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 70/261 (26%), Positives = 125/261 (47%), Gaps = 31/261 (11%) Query: 296 EGNEELRQKFERAKIGQGTKAPEEKTANTISKFDNNGNRDRMKLTDFNFLMVLGKGSFGK 355 +GN+ L QK + + P EK A I R+ +KL LG G FG+ Sbjct: 150 KGNDGLCQKLSVPCMSSKPQKPWEKDAWEIP-------RESLKLEK-----KLGAGQFGE 197 Query: 356 VMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDR 415 V ++ ++ AVK +K + VE + E V+ L +LH+ T + Sbjct: 198 VWMATYNKHTKV-AVKTMKPGSM----SVEAFLAEANVMKTLQHDK-LVKLHAVV-TKEP 250 Query: 416 LYFVMEYVNGGDLMYHIQQVGRFKEP--HAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVM 473 +Y + E++ G L+ ++ K+P + ++A+IA G+ F++ + I+RDL+ N++ Sbjct: 251 IYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANIL 310 Query: 474 LDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYE 533 + + KIADFG+ + V K + APE I + + D W+FG+LL E Sbjct: 311 VSASLVCKIADFGLAR------VGAKFPI---KWTAPEAINFGSFTIKSDVWSFGILLME 361 Query: 534 MLA-GQAPFEGEDEDELFQSI 553 ++ G+ P+ G E+ +++ Sbjct: 362 IVTYGRIPYPGMSNPEVIRAL 382 >4U41-A nrPDB Length = 332 Score = 76.6 bits (187), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 66/240 (27%), Positives = 107/240 (44%), Gaps = 33/240 (13%) Query: 322 ANTISKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQD 381 A ++ D + RD + F + V+G G++G+V T +L A+K++ DV + Sbjct: 8 AKSLVDIDLSSLRDPAGI--FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVM--DVTEDE 63 Query: 382 D---DVECTMVEK----RVLA------LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDL 428 + +E M++K R +A + PP H D+L+ VME+ G + Sbjct: 64 EEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPG----HD-----DQLWLVMEFCGAGSI 114 Query: 429 MYHIQQV--GRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFG 486 ++ KE + + EI GL L +I+RD+K NV+L +K+ DFG Sbjct: 115 TDLVKNTKGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFG 174 Query: 487 MCKENIWDGVTTKTFCGTPDYIAPEIIAYQ-----PYGKSVDWWAFGVLLYEMLAGQAPF 541 + + TF GTP ++APE+IA Y D W+ G+ EM G P Sbjct: 175 VSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPL 234 >5O2C-A nrPDB Length = 380 Score = 76.6 bits (187), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 57/213 (26%), Positives = 101/213 (47%), Gaps = 14/213 (6%) Query: 394 LALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIG 453 L P F S + + V E + G L ++++ K + +I G Sbjct: 81 LQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKG 140 Query: 454 LFFLQSKG--IIYRDLKLDNVMLDS-EGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAP 510 L FL ++ II+RDLK DN+ + G +KI D G+ + K+ GTP+++AP Sbjct: 141 LQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLA--TLMRTSFAKSVIGTPEFMAP 198 Query: 511 EIIAYQPYGKSVDWWAFGVLLYEMLAGQAPF-EGEDEDELFQSIME--HNVAYPKSMSKE 567 E+ + Y +SVD +AFG+ + EM + P+ E ++ ++++ + ++ K E Sbjct: 199 EMYE-EHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKVTDPE 257 Query: 568 AVAICKGLMTKHPGKRLGCGPEGERDIKEHAFF 600 I +G + ++ +RL RD+ HAFF Sbjct: 258 VKEIIEGCIRQNKSERLSI-----RDLLNHAFF 285 >5SYS-A nrPDB Length = 286 Score = 76.6 bits (187), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 56/210 (26%), Positives = 108/210 (51%), Gaps = 11/210 (5%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 407 LG+G FG+ + GT + A+K LK + + ++ V K++ + L QL+ Sbjct: 26 LGQGCFGECWMGTWNGTTRV-AIKTLKPGTMSPEAFLQEAQVMKKL-----RHEKLVQLY 79 Query: 408 SCFQTMDRLYFVMEYVNGGDLMYHIQ-QVGRF-KEPHAVFYAAEIAIGLFFLQSKGIIYR 465 + + + +Y V EY++ G L+ ++ ++G++ + P V AA+IA G+ +++ ++R Sbjct: 80 AVV-SEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHR 138 Query: 466 DLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTP-DYIAPEIIAYQPYGKSVDW 524 DL+ N+++ K+ADFG+ + + T + P + APE Y + D Sbjct: 139 DLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV 198 Query: 525 WAFGVLLYEMLA-GQAPFEGEDEDELFQSI 553 W+FG+LL E+ G+ P+ G E+ + Sbjct: 199 WSFGILLTELTTKGRVPYPGMVNREVLDQV 228 >5B2L-A nrPDB Length = 324 Score = 76.3 bits (186), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 75/291 (25%), Positives = 136/291 (46%), Gaps = 24/291 (8%) Query: 331 NGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVE 390 G R + ++ D L +G G+ G+V + T + AVK +++ ++ + +++ Sbjct: 8 GGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSG--NKEENKRILMD 65 Query: 391 KRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEI 450 V+ P++ Q F T ++ ME + G +++ + P + + Sbjct: 66 LDVVLKSHDCPYIVQCFGTFITNTDVFIAMELM--GTSAEKLKKRMQGPIPERILGKMTV 123 Query: 451 AI--GLFFLQSK-GIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDY 507 AI L++L+ K G+I+RD+K N++LD G IK+ DFG+ + T++ G Y Sbjct: 124 AIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRS-AGCAAY 182 Query: 508 IAPEII----AYQP-YGKSVDWWAFGVLLYEMLAGQAPFEG--EDEDELFQSIMEHNVAY 560 +APE I +P Y D W+ G+ L E+ GQ P++ D + L + + E Sbjct: 183 MAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLL 242 Query: 561 PKSM--SKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLE 609 P M S + + K +TK KR P+ + + EH+F + +E LE Sbjct: 243 PGHMGFSGDFQSFVKDCLTKDHRKR----PKYNK-LLEHSFIKR--YETLE 286 >2PL0-A nrPDB Length = 289 Score = 76.3 bits (186), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 62/224 (27%), Positives = 112/224 (50%), Gaps = 16/224 (7%) Query: 334 RDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRV 393 R+ +KL + LG G FG+V + G ++ AVK LK+ + D + + K++ Sbjct: 22 RETLKLVE-----RLGAGQFGEVWMGYYNGHTKV-AVKSLKQGSMSPDAFLAEANLMKQL 75 Query: 394 LALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEP--HAVFYAAEIA 451 + L +L++ T + +Y + EY+ G L+ ++ K + AA+IA Sbjct: 76 -----QHQRLVRLYAVV-TQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIA 129 Query: 452 IGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTP-DYIAP 510 G+ F++ + I+RDL+ N+++ KIADFG+ + + T + P + AP Sbjct: 130 EGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAP 189 Query: 511 EIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSI 553 E I Y + D W+FG+LL E++ G+ P+ G E+ Q++ Sbjct: 190 EAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNL 233 >4RC3-A nrPDB Length = 289 Score = 76.3 bits (186), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 64/251 (25%), Positives = 116/251 (46%), Gaps = 29/251 (11%) Query: 347 VLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDV--------ECTMVEKRVLALPG 398 +LG G FG V R + A+K ++KD + ++ E +++K G Sbjct: 19 LLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSG 78 Query: 399 KPPFLTQLHSCFQTMDRLYFVMEYVNG-GDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFL 457 + +L F+ D ++E DL I + G +E A + ++ + Sbjct: 79 ----VIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHC 134 Query: 458 QSKGIIYRDLKLDNVMLD-SEGHIKIADFG---MCKENIWDGVTTKTFCGTPDYIAPEII 513 + G+++RD+K +N+++D + G +K+ DFG + K+ ++ F GT Y PE I Sbjct: 135 HNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVY-----TDFDGTRVYSPPEWI 189 Query: 514 AYQPY-GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAIC 572 Y Y G+S W+ G+LLY+M+ G PFE ++E I+ V + + +S E + Sbjct: 190 RYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE------IIRGQVFFRQRVSSECQHLI 243 Query: 573 KGLMTKHPGKR 583 + + P R Sbjct: 244 RWCLALRPSDR 254 >5U6B-A nrPDB Length = 307 Score = 75.9 bits (185), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 61/227 (26%), Positives = 106/227 (46%), Gaps = 17/227 (7%) Query: 347 VLGKGSFGKVMLSERKGTDELYAVKILKKDVVI-QDDDVECTMVEKRVLALPGKPPFLTQ 405 LG+G FG VM + D + V + + I ++E + E + P + Sbjct: 30 TLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRL 89 Query: 406 LHSCFQTMDRLYF-----VMEYVNGGDLMYHIQQVGRFKEP------HAVFYAAEIAIGL 454 + CFQ +R F ++ ++ GDL + +P V + A+IA G+ Sbjct: 90 IGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGM 149 Query: 455 FFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKT--FCGTP-DYIAPE 511 +L +K I+RDL N ML+ + +ADFG+ K+ I++G + P +IA E Sbjct: 150 EYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKK-IYNGDYYRQGRIAKMPVKWIAIE 208 Query: 512 IIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIMEHN 557 +A + Y D W+FGV ++E+ GQ P+ G + E++ + + N Sbjct: 209 SLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGN 255 >4KRC-A nrPDB Length = 317 Score = 75.9 bits (185), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 57/226 (25%), Positives = 106/226 (46%), Gaps = 17/226 (7%) Query: 340 TDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK 399 + F L LG G++ V K T A+K +K D ++ T + + L K Sbjct: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLD---SEEGTPSTAIREISLMKELK 61 Query: 400 PPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAV------FYAAEIAIG 453 + +L+ T ++L V E+++ DL ++ P + ++ ++ G Sbjct: 62 HENIVRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 Query: 454 LFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCG---TPDYIAP 510 L F I++RDLK N++++ G +K+ DFG+ + G+ TF T Y AP Sbjct: 121 LAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAF---GIPVNTFSSEVVTLWYRAP 177 Query: 511 EII-AYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIME 555 +++ + Y S+D W+ G +L EM+ G+ F G +++E + I + Sbjct: 178 DVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFD 223 >3BGP-A nrPDB Length = 333 Score = 75.5 bits (184), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 64/251 (25%), Positives = 116/251 (46%), Gaps = 29/251 (11%) Query: 347 VLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDV--------ECTMVEKRVLALPG 398 +LG G FG V R + A+K ++KD + ++ E +++K G Sbjct: 63 LLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSG 122 Query: 399 KPPFLTQLHSCFQTMDRLYFVMEYVNG-GDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFL 457 + +L F+ D ++E DL I + G +E A + ++ + Sbjct: 123 ----VIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHC 178 Query: 458 QSKGIIYRDLKLDNVMLD-SEGHIKIADFG---MCKENIWDGVTTKTFCGTPDYIAPEII 513 + G+++RD+K +N+++D + G +K+ DFG + K+ ++ F GT Y PE I Sbjct: 179 HNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVY-----TDFDGTRVYSPPEWI 233 Query: 514 AYQPY-GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAIC 572 Y Y G+S W+ G+LLY+M+ G PFE ++E I+ V + + +S E + Sbjct: 234 RYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE------IIRGQVFFRQRVSSECQHLI 287 Query: 573 KGLMTKHPGKR 583 + + P R Sbjct: 288 RWCLALRPSDR 298 >4TPT-A nrPDB Length = 303 Score = 75.5 bits (184), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 55/210 (26%), Positives = 103/210 (49%), Gaps = 24/210 (11%) Query: 347 VLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQL 406 VLGKG FG+ + K T + V ++K+ + ++ + + E +V+ P L + Sbjct: 7 VLGKGFFGQAIKVTHKATGK---VMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFI 63 Query: 407 HSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRD 466 ++ +L + EY+ GG L ++ + F V +A IA G+ +L S II+RD Sbjct: 64 GVLYKD-KKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMAYLHSMCIIHRD 122 Query: 467 LKLDNVMLDSEGHIKIADFGMCKENI-------WDGVTTK-------------TFCGTPD 506 L N ++ + + +ADFG+ + + + TTK T G P Sbjct: 123 LNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGNPY 182 Query: 507 YIAPEIIAYQPYGKSVDWWAFGVLLYEMLA 536 ++APE++ + Y ++VD ++FG++L E++ Sbjct: 183 WMAPEMLNGKSYDETVDIFSFGIVLCEIIG 212 >5O2B-A nrPDB Length = 285 Score = 75.5 bits (184), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 53/191 (27%), Positives = 96/191 (50%), Gaps = 14/191 (7%) Query: 416 LYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKG--IIYRDLKLDNVM 473 + V E + G L ++++ K + +I GL FL ++ II+RDLK DN+ Sbjct: 94 IVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIF 153 Query: 474 LDS-EGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLY 532 + G +KI D G+ + K+ GTP+++APE+ + Y +SVD +AFG+ + Sbjct: 154 ITGPTGSVKIGDLGLA--TLMRTSFAKSVIGTPEFMAPEMYE-EHYDESVDVYAFGMCML 210 Query: 533 EMLAGQAPF-EGEDEDELFQSIME--HNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPE 589 EM + P+ E ++ ++++ + ++ K E I +G + ++ +RL Sbjct: 211 EMATSEYPYSECQNAAQIYRKVTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSI--- 267 Query: 590 GERDIKEHAFF 600 RD+ HAFF Sbjct: 268 --RDLLNHAFF 276 >4FL3-A nrPDB Length = 635 Score = 75.5 bits (184), Expect = 8e-14, Method: Compositional matrix adjust. Identities = 55/213 (25%), Positives = 100/213 (46%), Gaps = 19/213 (8%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTM-----VEKRVLALPGKPPF 402 LG G+FG V +KG ++ V +++++ + + E V+ P Sbjct: 377 LGSGNFGTV----KKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYI 432 Query: 403 LTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGI 462 + + C + VME G L ++QQ K+ + + ++++G+ +L+ Sbjct: 433 VRMIGIC--EAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNF 490 Query: 463 IYRDLKLDNVMLDSEGHIKIADFGMCK-----ENIWDGVTTKTFCGTPDYIAPEIIAYQP 517 ++RDL NV+L ++ + KI+DFG+ K EN + T + + APE I Y Sbjct: 491 VHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKW--PVKWYAPECINYYK 548 Query: 518 YGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDEL 549 + D W+FGVL++E + GQ P+ G E+ Sbjct: 549 FSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEV 581 >1FVR-A nrPDB Length = 327 Score = 75.5 bits (184), Expect = 8e-14, Method: Compositional matrix adjust. Identities = 60/232 (25%), Positives = 102/232 (43%), Gaps = 20/232 (8%) Query: 340 TDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK 399 D F V+G+G+FG+V+ + K I + DD E VL G Sbjct: 25 NDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGH 84 Query: 400 PPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQ----------------VGRFKEPHA 443 P + L + LY +EY G+L+ +++ Sbjct: 85 HPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQL 144 Query: 444 VFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCG 503 + +AA++A G+ +L K I+RDL N+++ KIADFG+ + + KT Sbjct: 145 LHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQ--EVYVKKTMGR 202 Query: 504 TP-DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSI 553 P ++A E + Y Y + D W++GVLL+E+++ G P+ G EL++ + Sbjct: 203 LPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKL 254 >6GQK-A nrPDB Length = 328 Score = 75.1 bits (183), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 71/268 (26%), Positives = 115/268 (42%), Gaps = 28/268 (10%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDE-----LYAVKILKKDVVIQDDDVECTMVEKRVLAL 396 +F LG G+FGKV+ + +G + AVK+LK + E M E +VL+ Sbjct: 43 LSFGKTLGAGAFGKVVEATAQGLIKSDAAMTVAVKMLKPSA--HSTEREALMSELKVLSY 100 Query: 397 PGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLM------------YHIQQVGRFKE---- 440 G + L + EY GDL+ Y + +K+ Sbjct: 101 LGNHENIVNLLGACTHGGPTLVITEYCCYGDLLNFLRRKRDEFVPYKVAPEDLYKDFLTL 160 Query: 441 PHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDG-VTTK 499 H + ++ ++A G+ FL SK I+RDL N++L KI DFG+ ++ D K Sbjct: 161 EHLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGNITKICDFGLARDIKNDSNYVDK 220 Query: 500 TFCGTP-DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIMEHN 557 P ++APE I Y D W++G+ L+E+ + G +P+ G D F +++ Sbjct: 221 GNARLPVKWMAPESIFNSVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEG 280 Query: 558 --VAYPKSMSKEAVAICKGLMTKHPGKR 583 ++ P+ E I K P KR Sbjct: 281 FRMSSPEYAPAEMYDIMKTCWDADPDKR 308 >2A1A-B nrPDB Length = 284 Score = 74.7 bits (182), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 57/205 (27%), Positives = 101/205 (49%), Gaps = 11/205 (5%) Query: 341 DFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVEC--TMVEKRVLALPG 398 DF + ++G G FG+V ++ + + Y +K +K + + +V+ + ++ G Sbjct: 12 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNG 71 Query: 399 ------KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVG--RFKEPHAVFYAAEI 450 P + +S L+ ME+ + G L I++ + + A+ +I Sbjct: 72 CWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQI 131 Query: 451 AIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAP 510 G+ ++ SK +I RDLK N+ L +KI DFG+ DG T++ GT Y++P Sbjct: 132 TKGVDYIHSKKLINRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRS-KGTLRYMSP 190 Query: 511 EIIAYQPYGKSVDWWAFGVLLYEML 535 E I+ Q YGK VD +A G++L E+L Sbjct: 191 EQISSQDYGKEVDLYALGLILAELL 215 >3UEY-A nrPDB Length = 65 Score = 74.7 bits (182), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 31/50 (62%), Positives = 39/50 (78%) Query: 102 HKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLC 151 H+FK+ Y SPTFCDHCGSLL+GL+ QG+KC+ C MNVH +C V +LC Sbjct: 10 HRFKVFNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLC 59 Score = 50.4 bits (119), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 22/54 (40%), Positives = 29/54 (53%) Query: 33 EVKNHKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSC 86 V +H+F + PTFC HC +WG KQG +C+ C VH +C E V C Sbjct: 6 SVGSHRFKVFNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLC 59 >3E3P-A nrPDB Length = 360 Score = 74.7 bits (182), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 71/237 (29%), Positives = 112/237 (47%), Gaps = 24/237 (10%) Query: 334 RDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRV 393 R R ++ F + G+G+FG V L + K T A+K + +D ++ +++ M + V Sbjct: 17 RSRKEMDRFQVERMAGQGTFGTVQLGKEKSTGMSVAIKKVIQDPRFRNRELQ-IMQDLAV 75 Query: 394 LALPGKPPFLTQLHSCFQTM---DR----LYFVMEYVNGGDLM------YHIQQVGRFKE 440 L P + QL S F T+ DR L VMEYV D + Y+ +QV Sbjct: 76 LHHPN----IVQLQSYFYTLGERDRRDIYLNVVMEYV--PDTLHRCCRNYYRRQVAPPPI 129 Query: 441 PHAVFYAAEI-AIGLFFLQSKGIIYRDLKLDNVMLD-SEGHIKIADFGMCKENIWDGVTT 498 VF I +IG L S + +RD+K NV+++ ++G +K+ DFG K+ Sbjct: 130 LIKVFLFQLIRSIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKLSPSEPNV 189 Query: 499 KTFCGTPDYIAPEII-AYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIM 554 C Y APE+I Q Y +VD W+ G + EM+ G+ F G++ I+ Sbjct: 190 AYICSR-YYRAPELIFGNQHYTTAVDIWSVGCIFAEMMLGEPIFRGDNSAGQLHEIV 245 >3GC9-A nrPDB Length = 370 Score = 74.7 bits (182), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 45/139 (32%), Positives = 77/139 (55%), Gaps = 5/139 (3%) Query: 418 FVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSE 477 +++ + G DL +I + + H F ++ GL ++ S GII+RDLK NV ++ + Sbjct: 109 YLVTTLMGADL-NNIVKSQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNED 167 Query: 478 GHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEI-IAYQPYGKSVDWWAFGVLLYEMLA 536 ++I DFG+ ++ D T + T Y APEI + + Y ++VD W+ G ++ E+L Sbjct: 168 SELRILDFGLARQA--DEEMTG-YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ 224 Query: 537 GQAPFEGEDEDELFQSIME 555 G+A F G D + + IME Sbjct: 225 GKALFPGSDYIDQLKRIME 243 >3QUP-A nrPDB Length = 323 Score = 74.3 bits (181), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 66/234 (28%), Positives = 113/234 (48%), Gaps = 20/234 (8%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELY---AVKILKKDVVIQDDDVECTMVEKRVLALPG 398 F +LGKG FG V ++ K D + AVK+LK D+ I D+E + E + Sbjct: 25 FTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADI-IASSDIEEFLREAACMKEFD 83 Query: 399 KPPFLTQLHSCFQTM--DRL---YFVMEYVNGGDLMYHI--QQVGR--FKEP--HAVFYA 447 P + ++ RL ++ ++ GDL + ++G F P V + Sbjct: 84 HPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLVRFM 143 Query: 448 AEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTP-- 505 +IA G+ +L S+ I+RDL N ML + + +ADFG+ ++ I+ G + C + Sbjct: 144 VDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRK-IYSGDYYRQGCASKLP 202 Query: 506 -DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIMEHN 557 ++A E +A Y D WAFGV ++E++ GQ P+ G + E++ ++ N Sbjct: 203 VKWLALESLADNLYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGN 256 >5H2U-A nrPDB Length = 267 Score = 74.3 bits (181), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 52/216 (24%), Positives = 100/216 (46%), Gaps = 8/216 (3%) Query: 341 DFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKP 400 +F LG G FG+V K ++ A+K++ +D ++ ++ + + L + Sbjct: 7 EFTLCRKLGSGYFGEVFEGLWKDRVQV-AIKVISRDNLLHQQMLQSEIQAMKKL----RH 61 Query: 401 PFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFY--AAEIAIGLFFLQ 458 + L++ D +Y + E + G L+ ++ P + A ++A G+ +L+ Sbjct: 62 KHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLE 121 Query: 459 SKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY 518 S+ I+RDL N+++ K+ DFG+ + D + + APE ++ Y Sbjct: 122 SQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEALSRGHY 181 Query: 519 GKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSI 553 D W+FG+LL+EM + GQ P+ G E F + Sbjct: 182 STKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRV 217 >5C26-A nrPDB Length = 299 Score = 73.9 bits (180), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 54/207 (26%), Positives = 98/207 (47%), Gaps = 19/207 (9%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTM-----VEKRVLALPGKPPF 402 LG G+FG V +KG ++ V +++++ + + E V+ P Sbjct: 35 LGSGNFGTV----KKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYI 90 Query: 403 LTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGI 462 + + C + VME G L ++QQ K+ + + ++++G+ +L+ Sbjct: 91 VRMIGIC--EAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNF 148 Query: 463 IYRDLKLDNVMLDSEGHIKIADFGMCK-----ENIWDGVTTKTFCGTPDYIAPEIIAYQP 517 ++RDL NV+L ++ + KI+DFG+ K EN + T + + APE I Y Sbjct: 149 VHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKW--PVKWYAPECINYYK 206 Query: 518 YGKSVDWWAFGVLLYEMLA-GQAPFEG 543 + D W+FGVL++E + GQ P+ G Sbjct: 207 FSSKSDVWSFGVLMWEAFSYGQKPYRG 233 >4LCV-A nrPDB Length = 138 Score = 73.9 bits (180), Expect = 2e-13, Method: Composition-based stats. Identities = 38/101 (37%), Positives = 58/101 (57%), Gaps = 2/101 (1%) Query: 169 DREVLIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFR 228 + L + AK L PMD NGL+DPYVKL L+P +K +TKT++ +LNP WNET Sbjct: 22 ENNALHCTISKAKGLKPMDHNGLADPYVKLHLLPGASKANKLRTKTLRNTLNPSWNETLT 81 Query: 229 FQ-LKESDKDRR-LSVEIWDWDLTSRNDFMGSLSFGISELQ 267 + + + D R+ L + + D D N+F+G + +L+ Sbjct: 82 YYGITDEDMIRKTLRISVCDEDKFRHNEFIGETRVPLKKLK 122 >4AU8-A nrPDB Length = 296 Score = 73.6 bits (179), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 56/214 (26%), Positives = 107/214 (50%), Gaps = 16/214 (7%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDD--VECTMVEKRVLALPGKPPFLTQ 405 +G+G++G V ++ + T E+ A+K ++ D DDD V + + + L K + + Sbjct: 14 IGEGTYGTVFKAKNRETHEIVALKRVRLD----DDDEGVPSSALREICLLKELKHKNIVR 69 Query: 406 LHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAV-FYAAEIAIGLFFLQSKGIIY 464 LH + +L V E+ + DL + +P V + ++ GL F S+ +++ Sbjct: 70 LHDVLHSDKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLH 128 Query: 465 RDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCG---TPDYIAPEII-AYQPYGK 520 RDLK N++++ G +K+ADFG+ + G+ + + T Y P+++ + Y Sbjct: 129 RDLKPQNLLINRNGELKLADFGLARAF---GIPVRCYSAEVVTLWYRPPDVLFGAKLYST 185 Query: 521 SVDWWAFGVLLYEML-AGQAPFEGEDEDELFQSI 553 S+D W+ G + E+ AG+ F G D D+ + I Sbjct: 186 SIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRI 219 >2OGV-A nrPDB Length = 317 Score = 73.6 bits (179), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 71/265 (26%), Positives = 123/265 (46%), Gaps = 24/265 (9%) Query: 340 TDFNFLMVLGKGSFGKVMLSERKGTDE-----LYAVKILKKDVVIQDDDVECTMVEKRVL 394 + F LG G+FGKV+ + G + AVK+LK D+ E M E +++ Sbjct: 38 NNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTA--HADEKEALMSELKIM 95 Query: 395 ALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQV---------GRFKEPHAVF 445 + G+ + L + + EY GDL+ +++ GR E + Sbjct: 96 SHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEADLDKEDGRPLELRDLL 155 Query: 446 -YAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHI-KIADFGMCKENIWDG-VTTKTFC 502 +++++A G+ FL SK I+RD+ NV+L + GH+ KI DFG+ ++ + D K Sbjct: 156 HFSSQVAQGMAFLASKNCIHRDVAARNVLL-TNGHVAKIGDFGLARDIMNDSNYIVKGNA 214 Query: 503 GTP-DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIME--HNV 558 P ++APE I Y D W++G+LL+E+ + G P+ G + F +++ + + Sbjct: 215 RLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQM 274 Query: 559 AYPKSMSKEAVAICKGLMTKHPGKR 583 A P K +I + P R Sbjct: 275 AQPAFAPKNIYSIMQACWALEPTHR 299 >5HLW-A nrPDB Length = 299 Score = 73.6 bits (179), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 61/211 (28%), Positives = 100/211 (47%), Gaps = 20/211 (9%) Query: 343 NFLMVLGKGSFGKV---MLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK 399 +F V+G+G FG V L + G AVK L + + +V + E ++ Sbjct: 23 HFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNR--ITDIGEVSQFLTEGIIMKDFSH 80 Query: 400 PPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPH------AVFYAAEIAIG 453 P L+ L C ++ V+ Y+ GDL I+ E H + + ++A G Sbjct: 81 PNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRN-----ETHNPTVKDLIGFGLQVAKG 135 Query: 454 LFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCK---ENIWDGVTTKTFCGTP-DYIA 509 + +L SK ++RDL N MLD + +K+ADFG+ + + + V KT P ++A Sbjct: 136 MKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMHDKEYYSVHNKTGAKLPVKWMA 195 Query: 510 PEIIAYQPYGKSVDWWAFGVLLYEMLAGQAP 540 E + Q + D W+FGVLL+E++ AP Sbjct: 196 LESLQTQKFTTKSDVWSFGVLLWELMTRGAP 226 >1U59-A nrPDB Length = 287 Score = 73.6 bits (179), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 63/222 (28%), Positives = 108/222 (48%), Gaps = 27/222 (12%) Query: 334 RDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDEL------YAVKILKKDVVIQDDDVECT 387 RD + + D LG G+FG V R+G + A+K+LK+ + D E Sbjct: 8 RDNLLIADIE----LGCGNFGSV----RQGVYRMRKKQIDVAIKVLKQGT--EKADTEEM 57 Query: 388 MVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKE---PHAV 444 M E +++ P + + C + L VME GG L H VG+ +E + Sbjct: 58 MREAQIMHQLDNPYIVRLIGVC--QAEALMLVMEMAGGGPL--HKFLVGKREEIPVSNVA 113 Query: 445 FYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDG--VTTKTFC 502 ++++G+ +L+ K ++RDL NV+L + + KI+DFG+ K D T ++ Sbjct: 114 ELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAG 173 Query: 503 GTP-DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFE 542 P + APE I ++ + D W++GV ++E L+ GQ P++ Sbjct: 174 KWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYK 215 >5AIR-A nrPDB Length = 430 Score = 73.2 bits (178), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 77/296 (26%), Positives = 126/296 (42%), Gaps = 61/296 (20%) Query: 335 DRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVE-------CT 387 DR + + V+G GSFG V ++ + EL A+K + +D ++ +++ C Sbjct: 59 DRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCN 118 Query: 388 MVEKRVLALPGKPPFLTQLHSCFQTMDRLYF--VMEYVNGGDLMYHI-QQVGRFKEPHAV 444 +V R +S + D +Y V++YV + +Y + + R K+ V Sbjct: 119 IVRLRYF-----------FYSSGEKKDEVYLNLVLDYV--PETVYRVARHYSRAKQTLPV 165 Query: 445 FYAAEIAIGLF----FLQSKGIIYRDLKLDNVMLDSEGHI-KIADFGMCKENIWDGVTTK 499 Y LF ++ S GI +RD+K N++LD + + K+ DFG K+ + Sbjct: 166 IYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVS 225 Query: 500 TFCGTPDYIAPEII-AYQPYGKSVDWWAFGVLLYEMLAGQAPFEGED-EDELF------- 550 C Y APE+I Y S+D W+ G +L E+L GQ F G+ D+L Sbjct: 226 YICSR-YYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLG 284 Query: 551 ----QSIMEHNVAY------------------PKSMSKEAVAICKGLMTKHPGKRL 584 + I E N Y P++ EA+A+C L+ P RL Sbjct: 285 TPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRT-PPEAIALCSRLLEYTPTARL 339 >4QNY-A nrPDB Length = 354 Score = 73.2 bits (178), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 54/207 (26%), Positives = 99/207 (47%), Gaps = 11/207 (5%) Query: 347 VLGKGSFGKVMLS-ERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA------LPGK 399 ++G GS+G V+ + + K + L A+K + K++ + + + E ++LA + G Sbjct: 27 IIGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFEEVILAKRILREIKLLAHFNDDNIIGL 86 Query: 400 PPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQS 459 LT + D Y VM+ + DL ++ E H F+ + L + S Sbjct: 87 RNILTPEDP--ENFDHFYIVMDIMET-DLKQVLRSGQELTEAHIQFFIYQALRALHIIHS 143 Query: 460 KGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAY-QPY 518 G+I+RD+ N+++++ +KI DFG+ KE G + Y APE++ + Y Sbjct: 144 AGVIHRDITPANILVNTNCDLKICDFGLAKEENDQGEYMTDYVTMRWYRAPELVMEDKDY 203 Query: 519 GKSVDWWAFGVLLYEMLAGQAPFEGED 545 +D W G +L E+L + F+G+D Sbjct: 204 SAQIDVWGIGCILGELLGSRPLFQGKD 230 >3UIU-A nrPDB Length = 306 Score = 72.8 bits (177), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 43/122 (35%), Positives = 69/122 (56%), Gaps = 3/122 (2%) Query: 416 LYFVMEYVNGGDLMYHIQQVG--RFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVM 473 L+ ME+ + G L I++ + + A+ +I G+ ++ SK +I+RDLK N+ Sbjct: 109 LFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIF 168 Query: 474 LDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYE 533 L +KI DFG+ DG T++ GT Y++PE I+ Q YGK VD +A G++L E Sbjct: 169 LVDTKQVKIGDFGLVTSLKNDGKRTRS-KGTLRYMSPEQISSQDYGKEVDLYALGLILAE 227 Query: 534 ML 535 +L Sbjct: 228 LL 229 >4HZS-A nrPDB Length = 341 Score = 72.8 bits (177), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 69/241 (28%), Positives = 108/241 (44%), Gaps = 32/241 (13%) Query: 341 DFNFLMVLGKGSFGKVMLSER---KGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALP 397 D L LG GSFG V E G AVK LK DV+ Q + ++ + E Sbjct: 13 DLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIRE------- 65 Query: 398 GKPPFLTQLHSC-FQTMDRLY---------FVMEYVNGGDLMYHIQQ-VGRFKEPHAVFY 446 + +HS + + RLY V E G L+ +++ G F Y Sbjct: 66 -----VNAMHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRY 120 Query: 447 AAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCK---ENIWDGVTTKTFCG 503 A ++A G+ +L+SK I+RDL N++L + +KI DFG+ + +N D + Sbjct: 121 AVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQND-DHYVMQEHRK 179 Query: 504 TP-DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIMEHNVAYP 561 P + APE + + + + D W FGV L+EM GQ P+ G + ++ I + P Sbjct: 180 VPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLP 239 Query: 562 K 562 + Sbjct: 240 R 240 >6DC0-A nrPDB Length = 292 Score = 72.8 bits (177), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 47/172 (27%), Positives = 79/172 (45%), Gaps = 13/172 (7%) Query: 426 GDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADF 485 GD+ +++ R +E A +I + I+ DLKL + +E ++ Sbjct: 82 GDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLE 141 Query: 486 GMCKENIW----DGVTTKTFCGTPDYIAPEII----AYQPYGKSVDWWAFGVLLYEMLAG 537 + +I D ++ K C P Y++PEI+ Y GK+ D W+ GV+LY +L G Sbjct: 142 SLEDTHIMKGEDDALSDKHGC--PAYVSPEILNTTGTYS--GKAADVWSLGVMLYTLLVG 197 Query: 538 QAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPE 589 + PF D LF I P+ +S +A + + L+ + P +RL PE Sbjct: 198 RYPFHDSDPSALFSKIRRGQFCIPEHISPKARCLIRSLLRREPSERL-TAPE 248 >5CEK-A nrPDB Length = 263 Score = 72.8 bits (177), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 47/172 (27%), Positives = 79/172 (45%), Gaps = 13/172 (7%) Query: 426 GDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADF 485 GD+ +++ R +E A +I + I+ DLKL + +E ++ Sbjct: 85 GDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLE 144 Query: 486 GMCKENIW----DGVTTKTFCGTPDYIAPEII----AYQPYGKSVDWWAFGVLLYEMLAG 537 + +I D ++ K C P Y++PEI+ Y GK+ D W+ GV+LY +L G Sbjct: 145 SLEDTHIMKGEDDALSDKHGC--PAYVSPEILNTTGTYS--GKAADVWSLGVMLYTLLVG 200 Query: 538 QAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPE 589 + PF D LF I P+ +S +A + + L+ + P +RL PE Sbjct: 201 RYPFHDSDPSALFSKIRRGQFCIPEHISPKARCLIRSLLRREPSERL-TAPE 251 >1U54-B nrPDB Length = 291 Score = 72.8 bits (177), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 69/241 (28%), Positives = 108/241 (44%), Gaps = 32/241 (13%) Query: 341 DFNFLMVLGKGSFGKVMLSER---KGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALP 397 D L LG GSFG V E G AVK LK DV+ Q + ++ + E Sbjct: 19 DLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIRE------- 71 Query: 398 GKPPFLTQLHSC-FQTMDRLY---------FVMEYVNGGDLMYHIQQ-VGRFKEPHAVFY 446 + +HS + + RLY V E G L+ +++ G F Y Sbjct: 72 -----VNAMHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRY 126 Query: 447 AAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCK---ENIWDGVTTKTFCG 503 A ++A G+ +L+SK I+RDL N++L + +KI DFG+ + +N D + Sbjct: 127 AVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQND-DHYVMQEHRK 185 Query: 504 TP-DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIMEHNVAYP 561 P + APE + + + + D W FGV L+EM GQ P+ G + ++ I + P Sbjct: 186 VPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLP 245 Query: 562 K 562 + Sbjct: 246 R 246 >3OHT-A nrPDB Length = 389 Score = 72.8 bits (177), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 46/148 (31%), Positives = 76/148 (51%), Gaps = 5/148 (3%) Query: 418 FVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSE 477 +++ ++ G DL +I + + + H F +I GL ++ S II+RDLK N+ ++ + Sbjct: 132 YLVTHLMGADLN-NIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNED 190 Query: 478 GHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEI-IAYQPYGKSVDWWAFGVLLYEMLA 536 +KI DFG+ + D T + T Y APEI + + Y +VD W+ G ++ E+L Sbjct: 191 CELKILDFGLARHT--DDEMTG-YVATRWYRAPEIMLNWMHYNMTVDIWSVGCIMAELLT 247 Query: 537 GQAPFEGEDEDELFQSIMEHNVAYPKSM 564 G+ F G D Q IM P S+ Sbjct: 248 GRTLFPGTDHINQLQQIMRLTGTPPASV 275 >2OZO-A nrPDB Length = 613 Score = 72.4 bits (176), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 65/224 (29%), Positives = 109/224 (48%), Gaps = 29/224 (12%) Query: 333 NRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDEL------YAVKILKKDVVIQDDDVEC 386 RD + + D LG G+FG V R+G + A+K+LK+ + D E Sbjct: 333 KRDNLLIADIE----LGCGNFGSV----RQGVYRMRKKQIDVAIKVLKQGT--EKADTEE 382 Query: 387 TMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFY 446 M E +++ P + + C + L VME GG L H VG+ +E V Sbjct: 383 MMREAQIMHQLDNPYIVRLIGVC--QAEALMLVMEMAGGGPL--HKFLVGK-REEIPVSN 437 Query: 447 AAE----IAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDG--VTTKT 500 AE +++G+ +L+ K ++R+L NV+L + + KI+DFG+ K D T ++ Sbjct: 438 VAELLHQVSMGMKYLEEKNFVHRNLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARS 497 Query: 501 FCGTP-DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFE 542 P + APE I ++ + D W++GV ++E L+ GQ P++ Sbjct: 498 AGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYK 541 >5WNO-A nrPDB Length = 330 Score = 72.4 bits (176), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 59/222 (26%), Positives = 104/222 (46%), Gaps = 20/222 (9%) Query: 348 LGKGSFGKVMLS-----ERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPF 402 LG G+FG V K A+K+ + D D+ M+E+ + Sbjct: 30 LGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTDQSQTDE-----MLEEATNMFRLRHDN 84 Query: 403 LTQLHSCFQTMDRLYFVMEYVNGGDLM----YHIQQVGRFKEPHAVFYAAEIAIGLFFLQ 458 L ++ D L V Y G+L H + +G ++ V Y +IA G+ +L+ Sbjct: 85 LLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKENLGAREQ---VLYCYQIASGMQYLE 141 Query: 459 SKGIIYRDLKLDNVMLDSEGHIKIADFGMCK--ENIWDGVTTKTFCGTPDYIAPEIIAYQ 516 + +++RDL NV++ H++I DFG+ K ++ D +T K+ ++A EI + Sbjct: 142 KQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIEIFSKH 201 Query: 517 PYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIMEHN 557 Y + D WAFGV +E++ GQ+P++G D + + + N Sbjct: 202 CYTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGN 243 >5U6C-A nrPDB Length = 315 Score = 72.4 bits (176), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 69/254 (27%), Positives = 117/254 (46%), Gaps = 23/254 (9%) Query: 339 LTDFNFLM---VLGKGSFGKVM---LSERKGTDELYAVKILKKDVVIQDDDVECTMVEKR 392 + D N L+ +LG+G FG VM L + GT AVK +K D Q + +E + E Sbjct: 32 VIDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQRE-IEEFLSEAA 90 Query: 393 VLALPGKPPFLTQLHSCF----QTMDRLYFVMEYVNGGDL----MYHIQQVGRFKEPHAV 444 + P + L C Q + + ++ ++ GDL +Y + G P Sbjct: 91 CMKDFSHPNVMRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQT 150 Query: 445 F--YAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKT-- 500 + +IA+G+ +L ++ ++RDL N ML + + +ADFG+ K+ I+ G + Sbjct: 151 LLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKK-IYSGDYYRQGR 209 Query: 501 FCGTP-DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIME-HN 557 P +IA E +A + Y D WAFGV ++E+ G P+ G E++ ++ H Sbjct: 210 IAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHR 269 Query: 558 VAYPKSMSKEAVAI 571 + P+ E I Sbjct: 270 LKQPEDCLDELYEI 283 >2GCD-A nrPDB Length = 309 Score = 72.0 bits (175), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 58/205 (28%), Positives = 93/205 (45%), Gaps = 12/205 (5%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 F+ L +G GSFG V + E+ A+K + ++ + + E R L + P Sbjct: 17 FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQ-KLRHP 75 Query: 402 FLTQLHSCFQTMDRLYFVMEYVNGG--DLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQS 459 Q C+ + VMEY G DL+ ++ + E AV + A GL +L S Sbjct: 76 NTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGA--LQGLAYLHS 133 Query: 460 KGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYG 519 +I+RD+K N++L G +K+ DFG +F GTP ++APE+I G Sbjct: 134 HNMIHRDVKAGNILLSEPGLVKLGDFGSAS----IMAPANSFVGTPYWMAPEVILAMDEG 189 Query: 520 K---SVDWWAFGVLLYEMLAGQAPF 541 + VD W+ G+ E+ + P Sbjct: 190 QYDGKVDVWSLGITCIELAERKPPL 214 >1U5R-A nrPDB Length = 348 Score = 72.0 bits (175), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 58/205 (28%), Positives = 93/205 (45%), Gaps = 12/205 (5%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 F+ L +G GSFG V + E+ A+K + ++ + + E R L + P Sbjct: 56 FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQ-KLRHP 114 Query: 402 FLTQLHSCFQTMDRLYFVMEYVNGG--DLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQS 459 Q C+ + VMEY G DL+ ++ + E AV + A GL +L S Sbjct: 115 NTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGA--LQGLAYLHS 172 Query: 460 KGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYG 519 +I+RD+K N++L G +K+ DFG +F GTP ++APE+I G Sbjct: 173 HNMIHRDVKAGNILLSEPGLVKLGDFGSASIM----APANSFVGTPYWMAPEVILAMDEG 228 Query: 520 K---SVDWWAFGVLLYEMLAGQAPF 541 + VD W+ G+ E+ + P Sbjct: 229 QYDGKVDVWSLGITCIELAERKPPL 253 >4OLI-A nrPDB Length = 645 Score = 72.0 bits (175), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 63/212 (29%), Positives = 97/212 (45%), Gaps = 41/212 (19%) Query: 348 LGKGSFGKVML----SERKGTDELYAVKILKKDV-------VIQDDDVECTMVEKRVLAL 396 LG+G FGKV L GT E+ AVK LK D Q+ D+ T+ + ++ Sbjct: 361 LGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKY 420 Query: 397 PGKPPFLTQLHSCF--QTMDRLYFVMEYVNGGDLMYHI--QQVGRFKEPHAVFYAAEIAI 452 G C Q L VMEYV G L ++ +G + + +A +I Sbjct: 421 KG----------CCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQ---LLLFAQQICE 467 Query: 453 GLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKE--------NIWDGVTTKTFCGT 504 G+ +L S+ I+R+L NV+LD++ +KI DFG+ K + + + F Sbjct: 468 GMAYLHSQHYIHRNLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVF--- 524 Query: 505 PDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA 536 + APE + + + D W+FGV LYE+L Sbjct: 525 --WYAPECLKEYKFYYASDVWSFGVTLYELLT 554 >2W1I-A nrPDB Length = 326 Score = 72.0 bits (175), Expect = 9e-13, Method: Compositional matrix adjust. Identities = 60/204 (29%), Positives = 95/204 (46%), Gaps = 12/204 (5%) Query: 342 FNFLMVLGKGSFGKVMLSE----RKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALP 397 FL LGKG+FG V + + T E+ AVK L+ D E E +L Sbjct: 43 LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFE---REIEILKSL 99 Query: 398 GKPPFLTQLHSCFQTMDR-LYFVMEYVNGGDLMYHIQQ-VGRFKEPHAVFYAAEIAIGLF 455 + C+ R L +MEY+ G L ++Q+ R + Y ++I G+ Sbjct: 100 QHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGME 159 Query: 456 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDG--VTTKTFCGTPDY-IAPEI 512 +L +K I+RDL N+++++E +KI DFG+ K D K +P + APE Sbjct: 160 YLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPES 219 Query: 513 IAYQPYGKSVDWWAFGVLLYEMLA 536 + + + D W+FGV+LYE+ Sbjct: 220 LTESKFSVASDVWSFGVVLYELFT 243 >3V5Q-A nrPDB Length = 297 Score = 72.0 bits (175), Expect = 9e-13, Method: Compositional matrix adjust. Identities = 68/262 (25%), Positives = 111/262 (42%), Gaps = 29/262 (11%) Query: 348 LGKGSFGKVMLSERKGTDE-----LYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPF 402 LG+G+FGKV L+E L AVK LK + D + + L + Sbjct: 23 LGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQ----REAELLTNLQHEH 78 Query: 403 LTQLHSCFQTMDRLYFVMEYVNGGDLMYHI----------------QQVGRFKEPHAVFY 446 + + + D L V EY+ GDL + Q G + Sbjct: 79 IVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHI 138 Query: 447 AAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENI-WDGVTTKTFCGTP 505 A++IA G+ +L S+ ++RDL N ++ + +KI DFGM ++ D P Sbjct: 139 ASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLP 198 Query: 506 -DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIMEHNVA-YPK 562 ++ PE I Y+ + D W+FGV+L+E+ G+ P+ E+ + I + V P+ Sbjct: 199 IRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPR 258 Query: 563 SMSKEAVAICKGLMTKHPGKRL 584 KE + G + P +RL Sbjct: 259 VCPKEVYDVMLGCWQREPQQRL 280 >3IO7-A nrPDB Length = 313 Score = 71.6 bits (174), Expect = 9e-13, Method: Compositional matrix adjust. Identities = 60/204 (29%), Positives = 95/204 (46%), Gaps = 12/204 (5%) Query: 342 FNFLMVLGKGSFGKVMLSE----RKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALP 397 FL LGKG+FG V + + T E+ AVK L+ D E E +L Sbjct: 30 LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFE---REIEILKSL 86 Query: 398 GKPPFLTQLHSCFQTMDR-LYFVMEYVNGGDLMYHIQQ-VGRFKEPHAVFYAAEIAIGLF 455 + C+ R L +MEY+ G L ++Q+ R + Y ++I G+ Sbjct: 87 QHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGME 146 Query: 456 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDG--VTTKTFCGTPDY-IAPEI 512 +L +K I+RDL N+++++E +KI DFG+ K D K +P + APE Sbjct: 147 YLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPES 206 Query: 513 IAYQPYGKSVDWWAFGVLLYEMLA 536 + + + D W+FGV+LYE+ Sbjct: 207 LTESKFSVASDVWSFGVVLYELFT 230 >3KRL-A nrPDB Length = 335 Score = 71.6 bits (174), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 72/275 (26%), Positives = 121/275 (44%), Gaps = 38/275 (13%) Query: 340 TDFNFLMVLGKGSFGKVMLSERKGTDE-----LYAVKILKKDVVIQDDDVECTMVEKRVL 394 + F LG G+FGKV+ + G + AVK+LK D+ E M E +++ Sbjct: 46 NNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTA--HADEKEALMSELKIM 103 Query: 395 ALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYA------- 447 + G+ + L + + EY GDL+ + R K P + Y+ Sbjct: 104 SHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFL----RRKRPPGLEYSYNPSHNP 159 Query: 448 -------------AEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHI-KIADFGMCKENIW 493 +++A G+ FL SK I+RD+ NV+L + GH+ KI DFG+ ++ + Sbjct: 160 EEQLSSRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLL-TNGHVAKIGDFGLARDIMN 218 Query: 494 DG-VTTKTFCGTP-DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELF 550 D K P ++APE I Y D W++G+LL+E+ + G P+ G + F Sbjct: 219 DSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKF 278 Query: 551 QSIME--HNVAYPKSMSKEAVAICKGLMTKHPGKR 583 +++ + +A P K +I + P R Sbjct: 279 YKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHR 313 >4XUF-A nrPDB Length = 297 Score = 71.2 bits (173), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 62/247 (25%), Positives = 111/247 (44%), Gaps = 33/247 (13%) Query: 341 DFNFLMVLGKGSFGKVMLS-----ERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 395 + F VLG G+FGKVM + + G AVK+LK+ + E M E +++ Sbjct: 10 NLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKA--DSSEREALMSELKMMT 67 Query: 396 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQ-QVGRFKEPHAVF--------- 445 G + L +Y + EY GDL+ +++ + +F E + Sbjct: 68 QLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRLEEE 127 Query: 446 -------------YAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENI 492 +A ++A G+ FL+ K ++RDL NV++ +KI DFG+ ++ + Sbjct: 128 EDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIM 187 Query: 493 WDG-VTTKTFCGTP-DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDEL 549 D + P ++APE + Y D W++G+LL+E+ + G P+ G D Sbjct: 188 SDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDAN 247 Query: 550 FQSIMEH 556 F ++++ Sbjct: 248 FYKLIQN 254 >4GS6-A nrPDB Length = 315 Score = 70.9 bits (172), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 62/247 (25%), Positives = 121/247 (48%), Gaps = 23/247 (9%) Query: 347 VLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQL 406 V+G+G+FG V ++ + D A+K ++ + + + +VE R L+ P + Sbjct: 16 VVGRGAFGVVCKAKWRAKD--VAIKQIE-----SESERKAFIVELRQLSRVNHPNIVKLY 68 Query: 407 HSCFQTMDRLYFVMEYVNGGDL---MYHIQQVGRFKEPHAVFYAAEIAIGLFFLQS---K 460 +C ++ + VMEY GG L ++ + + + HA+ + + + G+ +L S K Sbjct: 69 GAC---LNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPK 125 Query: 461 GIIYRDLKLDNVMLDSEGHI-KIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYG 519 +I+RDLK N++L + G + KI DFG +I +T G+ ++APE+ Y Sbjct: 126 ALIHRDLKPPNLLLVAGGTVLKICDFGTAC-DIQTHMTNNK--GSAAWMAPEVFEGSNYS 182 Query: 520 KSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYP---KSMSKEAVAICKGLM 576 + D +++G++L+E++ + PF+ HN P K++ K ++ Sbjct: 183 EKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCW 242 Query: 577 TKHPGKR 583 +K P +R Sbjct: 243 SKDPSQR 249 >1CM8-A nrPDB Length = 367 Score = 70.9 bits (172), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 53/167 (31%), Positives = 87/167 (52%), Gaps = 15/167 (8%) Query: 417 YFVMEYVNG--GDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVML 474 Y VM ++ G LM H +++G E F ++ GL ++ + GII+RDLK N+ + Sbjct: 106 YLVMPFMGTDLGKLMKH-EKLG---EDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAV 161 Query: 475 DSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA-YQPYGKSVDWWAFGVLLYE 533 + + +KI DFG+ ++ D T + T Y APE+I + Y ++VD W+ G ++ E Sbjct: 162 NEDCELKILDFGLARQA--DSEMT-GYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAE 218 Query: 534 MLAGQAPFEGEDEDELFQSIMEHNVAYP-----KSMSKEAVAICKGL 575 M+ G+ F+G D + + IM+ P + S EA KGL Sbjct: 219 MITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGL 265 >6DBM-A nrPDB Length = 318 Score = 70.9 bits (172), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 63/211 (29%), Positives = 97/211 (45%), Gaps = 41/211 (19%) Query: 348 LGKGSFGKVML----SERKGTDELYAVKILKKDV-------VIQDDDVECTMVEKRVLAL 396 LG+G FGKV L GT E+ AVK LK D Q+ D+ T+ + ++ Sbjct: 39 LGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAGPQHRSGWKQEIDILRTLYHEHIIKY 98 Query: 397 PGKPPFLTQLHSCFQTMD--RLYFVMEYVNGGDLMYHI--QQVGRFKEPHAVFYAAEIAI 452 G C + L VMEYV G L ++ +G + + +A +I Sbjct: 99 KG----------CCEDAGAASLQLVMEYVPLGSLRDYLPRHSIGLAQ---LLLFAQQICE 145 Query: 453 GLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKE--------NIWDGVTTKTFCGT 504 G+ +L S+ I+RDL NV+LD++ +KI DFG+ K + + + F Sbjct: 146 GMAYLHSQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVF--- 202 Query: 505 PDYIAPEIIAYQPYGKSVDWWAFGVLLYEML 535 + APE + + + D W+FGV LYE+L Sbjct: 203 --WYAPECLKEYKFYYASDVWSFGVTLYELL 231 >4R7H-A nrPDB Length = 343 Score = 70.9 bits (172), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 69/278 (24%), Positives = 124/278 (44%), Gaps = 37/278 (13%) Query: 340 TDFNFLMVLGKGSFGKVMLSERKGTDE-----LYAVKILKKDVVIQDDDVECTMVEKRVL 394 + F LG G+FGKV+ + G + AVK+LK D+ E M E +++ Sbjct: 50 NNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTA--HADEKEALMSELKIM 107 Query: 395 ALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQ---------VGRFKEPHAV- 444 + G+ + L + + EY GDL+ +++ + ++P + Sbjct: 108 SHLGQHENIVNLLGACTHGGPVLVITEYCTYGDLLNFLRRKAEAMLGPSLSPGQDPEGLD 167 Query: 445 -------------FYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHI-KIADFGMCKE 490 +++++A G+ FL SK I+RD+ NV+L + GH+ KI DFG+ ++ Sbjct: 168 KEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLL-TNGHVAKIGDFGLARD 226 Query: 491 NIWDG-VTTKTFCGTP-DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDED 547 + D K P ++APE I Y D W++G+LL+E+ + G P+ G + Sbjct: 227 IMNDSNYIVKGNARLPVKWMAPESIFDSVYTVQSDVWSYGILLWEIFSLGLNPYPGILVN 286 Query: 548 ELFQSIME--HNVAYPKSMSKEAVAICKGLMTKHPGKR 583 F +++ + +A P K +I + P R Sbjct: 287 SKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHR 324 >5X02-A nrPDB Length = 347 Score = 70.9 bits (172), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 62/247 (25%), Positives = 111/247 (44%), Gaps = 33/247 (13%) Query: 341 DFNFLMVLGKGSFGKVMLS-----ERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 395 + F VLG G+FGKVM + + G AVK+LK+ + E M E +++ Sbjct: 49 NLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKA--DSSEREALMSELKMMT 106 Query: 396 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQ-QVGRFKEPHAVF--------- 445 G + L +Y + EY GDL+ +++ + +F E + Sbjct: 107 QLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRLEEE 166 Query: 446 -------------YAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENI 492 +A ++A G+ FL+ K ++RDL NV++ +KI DFG+ ++ + Sbjct: 167 EDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIM 226 Query: 493 WDG-VTTKTFCGTP-DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDEL 549 D + P ++APE + Y D W++G+LL+E+ + G P+ G D Sbjct: 227 SDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDAN 286 Query: 550 FQSIMEH 556 F ++++ Sbjct: 287 FYKLIQN 293 >3ZDU-A nrPDB Length = 325 Score = 70.5 bits (171), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 54/216 (25%), Positives = 91/216 (42%), Gaps = 20/216 (9%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 407 +G+GS+G VM + K T ++ A+KI + + + R + FL Q H Sbjct: 11 VGEGSYGTVMKCKHKNTGQIVAIKIF-----YERPEQSVNKIAMREIK------FLKQFH 59 Query: 408 --------SCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQS 459 F+ +++ V E+++ L + Y +I + +L S Sbjct: 60 HENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHS 119 Query: 460 KGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAY-QPY 518 II+RD+K +N+++ G K+ DFG + G T Y APE++ Y Sbjct: 120 NNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYDDEVATRWYRAPELVLKDTSY 179 Query: 519 GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIM 554 GK VD WA G ++ EM G + +L I+ Sbjct: 180 GKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIV 215 >2H34-A nrPDB Length = 309 Score = 70.5 bits (171), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 62/262 (23%), Positives = 116/262 (44%), Gaps = 10/262 (3%) Query: 333 NRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKR 392 +R+ + + ++G+G G V +E + + A+K++ + + D V T +++ Sbjct: 27 SREGTQFGPYRLRRLVGRGGMGDVYEAEDTVRERIVALKLMSE--TLSSDPVFRTRMQRE 84 Query: 393 V-LALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIA 451 A + P + +H + +LY M +NG DL +++ G P AV +I Sbjct: 85 ARTAGRLQEPHVVPIHDFGEIDGQLYVDMRLINGVDLAAMLRRQGPLAPPRAVAIVRQIG 144 Query: 452 IGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTT-KTFCGTPDYIAP 510 L + G +RD+K +N+++ ++ + DFG+ + +T GT Y+AP Sbjct: 145 SALDAAHAAGATHRDVKPENILVSADDFAYLVDFGIASATTDEKLTQLGNTVGTLYYMAP 204 Query: 511 EIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDED----ELFQSIMEHNVAYPKSMSK 566 E + D +A +LYE L G P++G+ + Q+I + P Sbjct: 205 ERFSESHATYRADIYALTCVLYECLTGSPPYQGDQLSVMGAHINQAIPRPSTVRPGIPVA 264 Query: 567 EAVAICKGLMTKHPGKR-LGCG 587 I +G M K+P R + CG Sbjct: 265 FDAVIARG-MAKNPEDRYVTCG 285 >4NST-A nrPDB Length = 351 Score = 70.1 bits (170), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 51/218 (23%), Positives = 108/218 (49%), Gaps = 16/218 (7%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKD--------VVIQDDDVECTMVEKRV 393 F+ + ++G+G++G+V ++ K T EL A+K ++ D I++ + ++ + V Sbjct: 15 FDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSV 74 Query: 394 LALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQ-VGRFKEPHAVFYAAEIAI 452 + + + Y V EY++ DLM ++ + F E H + ++ Sbjct: 75 VNMKEIVTDKQDALDFKKDKGAFYLVFEYMDH-DLMGLLESGLVHFSEDHIKSFMKQLME 133 Query: 453 GLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCG---TPDYIA 509 GL + K ++RD+K N++L++ G IK+ADFG+ + +++ ++ + T Y Sbjct: 134 GLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLAR--LYNSEESRPYTNKVITLWYRP 191 Query: 510 PE-IIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDE 546 PE ++ + Y ++D W+ G +L E+ + F+ E Sbjct: 192 PELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLE 229 >2I6L-A nrPDB Length = 320 Score = 69.7 bits (169), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 47/153 (30%), Positives = 79/153 (51%), Gaps = 17/153 (11%) Query: 413 MDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNV 472 ++ +Y V EY+ DL ++Q G E HA + ++ GL ++ S +++RDLK N+ Sbjct: 94 LNSVYIVQEYMET-DLANVLEQ-GPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANL 151 Query: 473 MLDSEGHI-KIADFGMC---------KENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSV 522 +++E + KI DFG+ K ++ +G+ TK + ++P Y K++ Sbjct: 152 FINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWYRSPRLLLSP-----NNYTKAI 206 Query: 523 DWWAFGVLLYEMLAGQAPFEGEDEDELFQSIME 555 D WA G + EML G+ F G E E Q I+E Sbjct: 207 DMWAAGCIFAEMLTGKTLFAGAHELEQMQLILE 239 >6J5U-C nrPDB Length = 426 Score = 69.7 bits (169), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 61/207 (29%), Positives = 96/207 (46%), Gaps = 19/207 (9%) Query: 347 VLGKGSFGKV---------MLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALP 397 +LG+G FG V + + R G+ + AVK LK + + + E L Sbjct: 91 LLGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQLKPEGFQGHKEW---LTEVNYLGQL 147 Query: 398 GKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFY--AAEIAIGLF 455 P + + C + +RL V E++ G L H+ + G A+ A A GL Sbjct: 148 SHPNLVLLVGYCAEGENRL-LVYEFMPKGSLENHLFRRGAQPLTWAIRMKVAVGAAKGLT 206 Query: 456 FLQ--SKGIIYRDLKLDNVMLDSEGHIKIADFGMCKEN-IWDGVTTKT-FCGTPDYIAPE 511 FL +IYRD K N++LD++ + K++DFG+ K D T GT Y APE Sbjct: 207 FLHEAKSQVIYRDFKAANILLDADFNAKLSDFGLAKAGPTGDNTHVSTKVIGTHGYAAPE 266 Query: 512 IIAYQPYGKSVDWWAFGVLLYEMLAGQ 538 +A D ++FGV+L E+++G+ Sbjct: 267 YVATGRLTAKSDVYSFGVVLLELISGR 293 >6FEX-A nrPDB Length = 321 Score = 69.7 bits (169), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 72/238 (30%), Positives = 108/238 (45%), Gaps = 45/238 (18%) Query: 348 LGKGSFGKVMLSE----------------RKGTDELYAVKILKKDVV--IQDDDVECTMV 389 LG+G FG+V L E RKG L AVKIL+ D ++D ++ Sbjct: 24 LGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARNDFLK---- 79 Query: 390 EKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHI---QQVGRFKE------ 440 E ++++ P + L C Q D L + +Y+ GDL + Q + E Sbjct: 80 EVKIMSRLKDPNIIRLLGVCVQD-DPLCMITDYMENGDLNQFLSAHQLEDKAAEGAPGDP 138 Query: 441 ----PHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDG- 495 P + AA+IA G+ +L + ++RDL N ++ IKIADFGM + N++ G Sbjct: 139 TISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSR-NLYAGD 197 Query: 496 ---VTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYE--MLAGQAPFEGEDEDE 548 V + ++A E I + + D WAFGV L+E ML PF G+ DE Sbjct: 198 YYRVQGRAVLPI-RWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPF-GQLTDE 253 >5Y86-A nrPDB Length = 588 Score = 69.7 bits (169), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 58/219 (26%), Positives = 96/219 (43%), Gaps = 9/219 (4%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 + L ++GKGSFG+V + A+K+++ + E + + L K Sbjct: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEH-LKKQDKTG 267 Query: 402 FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVF---YAAEIAIGLFFLQ 458 + +H R + M + +Y + + +F+ +A I L L Sbjct: 268 SMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALH 327 Query: 459 SKGIIYRDLKLDNVMLDSEGH--IKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQ 516 II+ DLK +N++L G K+ DFG + ++ T+ + Y APEII Sbjct: 328 KNKIIHCDLKPENILLKHHGRSSTKVIDFG---SSCFEYQKLYTYIQSRFYRAPEIILGS 384 Query: 517 PYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIME 555 Y +D W+FG +L E+L GQ F GEDE + +ME Sbjct: 385 RYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMME 423 >3KUL-B nrPDB Length = 325 Score = 69.3 bits (168), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 46/160 (28%), Positives = 79/160 (49%), Gaps = 5/160 (3%) Query: 401 PFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQ-QVGRFKEPHAVFYAAEIAIGLFFLQS 459 P + +L V EY+ G L ++ G+F V + G+ +L Sbjct: 110 PNIIRLEGVVTRGRLAMIVTEYMENGSLDTFLRTHDGQFTIMQLVGMLRGVGAGMRYLSD 169 Query: 460 KGIIYRDLKLDNVMLDSEGHIKIADFGMCK--ENIWDGVTTKTFCGTP-DYIAPEIIAYQ 516 G ++RDL NV++DS K++DFG+ + E+ D T T P + APE IA++ Sbjct: 170 LGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTAPEAIAFR 229 Query: 517 PYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIME 555 + + D W+FGV+++E+LA G+ P+ ++ S+ E Sbjct: 230 TFSSASDVWSFGVVMWEVLAYGERPYWNMTNRDVISSVEE 269 >2WO6-A nrPDB Length = 382 Score = 69.3 bits (168), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 59/221 (26%), Positives = 101/221 (45%), Gaps = 21/221 (9%) Query: 347 VLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP----- 401 ++GKGSFG+V+ + + E A+KI+K + +E R+L L K Sbjct: 61 LIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQ----AQIEVRLLELMNKHDTEMKY 116 Query: 402 FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVF---YAAEIAIGLFFLQ 458 ++ L F + L V E ++ +Y + + F+ +A ++ L FL Sbjct: 117 YIVHLKRHFMFRNHLCLVFEMLSYN--LYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLA 174 Query: 459 SK--GIIYRDLKLDNVML--DSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA 514 + II+ DLK +N++L IKI DFG + G + + Y +PE++ Sbjct: 175 TPELSIIHCDLKPENILLCNPKRSAIKIVDFG---SSCQLGQRIYQYIQSRFYRSPEVLL 231 Query: 515 YQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIME 555 PY ++D W+ G +L EM G+ F G +E + I+E Sbjct: 232 GMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVE 272 >4PWN-A nrPDB Length = 274 Score = 69.3 bits (168), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 53/194 (27%), Positives = 96/194 (49%), Gaps = 17/194 (8%) Query: 416 LYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKG--IIYRDLKLDNVM 473 + V E + G L ++++ K + +I GL FL ++ II+RDLK DN+ Sbjct: 88 IVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIF 147 Query: 474 LDS-EGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLY 532 + G +KI D G+ K+ GTP+++APE+ + Y +SVD +AFG+ + Sbjct: 148 ITGPTGSVKIGDLGLATLEKRASFA-KSVIGTPEFMAPEMYE-EKYDESVDVYAFGMCML 205 Query: 533 EMLAGQAPF-EGEDEDELFQSIMEHNVAYPKSMSKEAV----AICKGLMTKHPGKRLGCG 587 EM + P+ E ++ ++++ + P S K A+ I +G + ++ +R Sbjct: 206 EMATSEYPYSECQNAAQIYRRVTSG--VKPASFDKVAIPEVKEIIEGCIRQNKDERYSI- 262 Query: 588 PEGERDIKEHAFFR 601 +D+ HAFF+ Sbjct: 263 ----KDLLNHAFFQ 272 >4EWQ-A nrPDB Length = 383 Score = 69.3 bits (168), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 42/138 (30%), Positives = 75/138 (54%), Gaps = 5/138 (3%) Query: 418 FVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSE 477 +++ ++ G DL +I + + + H F +I GL ++ S II+RDLK N+ ++ + Sbjct: 126 YLVTHLMGADL-NNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNED 184 Query: 478 GHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEI-IAYQPYGKSVDWWAFGVLLYEMLA 536 +KI DFG+ + D T + T Y APEI + + Y ++VD W+ G ++ E+L Sbjct: 185 CELKILDFGLARHT--DDEMTG-YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT 241 Query: 537 GQAPFEGEDEDELFQSIM 554 G+ F G D + + I+ Sbjct: 242 GRTLFPGTDHIDQLKLIL 259 >6DTL-A nrPDB Length = 364 Score = 69.3 bits (168), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 53/226 (23%), Positives = 103/226 (45%), Gaps = 28/226 (12%) Query: 345 LMVLGKGSFGKVMLSERKGTDELYAVK--------------ILKKDVVIQDDDVECTMVE 390 +M +GKG++G V + T+E A+K L++ +++ D E + Sbjct: 35 IMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAI 94 Query: 391 KRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEI 450 + ++ P + F ++ ++ MD DL I+ E H ++ +I Sbjct: 95 RDIIPPPLRNAF-NDVYIAYELMD-----------TDLHQIIRSNQALSEEHCQYFLYQI 142 Query: 451 AIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAP 510 GL ++ S +++RDLK N++L++ +KI DFG+ + T+ + T Y AP Sbjct: 143 LRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTE-YVVTRWYRAP 201 Query: 511 EIIAYQP-YGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIME 555 E++ Y ++D W+ G + E++ + F G D + +ME Sbjct: 202 ELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLME 247 >5ZTN-A nrPDB Length = 429 Score = 69.3 bits (168), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 57/219 (26%), Positives = 99/219 (45%), Gaps = 9/219 (4%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 + L V+GKGSFG+V+ + + A+K+++ + E + + L K Sbjct: 99 YEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEH-LRKQDKDN 157 Query: 402 FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKE---PHAVFYAAEIAIGLFFLQ 458 + +H R + M + +Y + + +F+ P +A I L L Sbjct: 158 TMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALH 217 Query: 459 SKGIIYRDLKLDNVMLDSEGH--IKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQ 516 II+ DLK +N++L +G IK+ DFG + ++ T+ + Y APE+I Sbjct: 218 KNRIIHCDLKPENILLKQQGRSGIKVIDFG---SSCYEHQRVYTYIQSRFYRAPEVILGA 274 Query: 517 PYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIME 555 YG +D W+ G +L E+L G GEDE + ++E Sbjct: 275 RYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIE 313 >6CTH-A nrPDB Length = 309 Score = 68.9 bits (167), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 56/214 (26%), Positives = 103/214 (48%), Gaps = 11/214 (5%) Query: 340 TDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK 399 ++FN LG+G FG V + +D AVK + + ++ E ++++ Sbjct: 15 SNFNAENKLGEGGFGSVYRGFLRDSDTYIAVKKVSR---ASKQGIKEYASEVKIISRLRH 71 Query: 400 PPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFY--AAEIAIGLFFL 457 + + C + + L V E++ G L HI + G+ V Y ++A L +L Sbjct: 72 KNLVKLIGWCHERGE-LMLVYEFMANGSLDSHIFK-GKSLLTWEVRYRIVKDLASALLYL 129 Query: 458 QSKG---IIYRDLKLDNVMLDSEGHIKIADFGMCK-ENIWDGVTTKTFCGTPDYIAPEII 513 +G +++RD+K N+MLDS + K+ DFG+ + + G+ GT Y+APE + Sbjct: 130 HEEGDHCVLHRDIKTSNIMLDSSFNAKLGDFGLARLVDHAKGLKKTLLAGTVGYMAPECL 189 Query: 514 AYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDED 547 + K D ++FGV+ E+ +G+ E + E+ Sbjct: 190 SSGKASKESDVYSFGVVALEIASGRRSIEPKFEE 223 >6BSD-A nrPDB Length = 876 Score = 68.9 bits (167), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 68/249 (27%), Positives = 106/249 (42%), Gaps = 46/249 (18%) Query: 348 LGKGSFGKVMLSE----------------RKGTDELYAVKILKKDVVIQDDDVECTMVEK 391 LG+G FG+V L E RKG L AVKIL+ D + + E Sbjct: 579 LGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDAT--KNARNDFLKEV 636 Query: 392 RVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQ------------------ 433 ++++ P + L C Q D L + +Y+ GDL + Sbjct: 637 KIMSRLKDPNIIRLLGVCVQD-DPLCMITDYMENGDLNQFLSAHQLEDKAAEGAPGDGQA 695 Query: 434 -QVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENI 492 Q P + AA+IA G+ +L + ++RDL N ++ IKIADFGM + N+ Sbjct: 696 AQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSR-NL 754 Query: 493 WDG----VTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYE--MLAGQAPFEGEDE 546 + G V + ++A E I + + D WAFGV L+E ML PF + Sbjct: 755 YAGDYYRVQGRAVLPI-RWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTD 813 Query: 547 DELFQSIME 555 +++ ++ E Sbjct: 814 EQVIENAGE 822 >5Z33-A nrPDB Length = 425 Score = 68.9 bits (167), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 58/227 (25%), Positives = 103/227 (45%), Gaps = 33/227 (14%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 407 LG+G++G V + T E A+K + + K++LA H Sbjct: 39 LGQGAYGIVCAAVNNQTSEGVAIKKV------------TNVFSKKILAKRALREIKLLQH 86 Query: 408 -------SCFQTMD-------RLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIG 453 +C MD ++ E + DL I+ + H + +I G Sbjct: 87 FRGHRNITCLYDMDIPRPDNFNETYLYEELMECDLAAIIRSGQPLTDAHFQSFIYQILCG 146 Query: 454 LFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWD-----GVTTKTFCGTPDYI 508 L ++ S +++RDLK N++++++ +KI DFG+ + D G T+ + T Y Sbjct: 147 LKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSVDPEENAGYMTE-YVATRWYR 205 Query: 509 APEI-IAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIM 554 APEI +++Q Y K++D W+ G +L E+L G+ F+G D + I+ Sbjct: 206 APEIMLSFQSYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQIL 252 >5GRN-A nrPDB Length = 356 Score = 68.9 bits (167), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 67/273 (24%), Positives = 113/273 (41%), Gaps = 38/273 (13%) Query: 347 VLGKGSFGKVMLSERKGTDEL-----YAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 VLG G+FGKV+ G AVK+LK + + + M E +++ G Sbjct: 53 VLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTA--RSSEKQALMSELKIMTHLGPHL 110 Query: 402 FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPH------------------- 442 + L +Y + EY GDL+ ++ + H Sbjct: 111 NIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHKKKSMLDSEVKNLLSDDNS 170 Query: 443 -------AVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDG 495 + + ++A G+ FL SK ++RDL NV+L +KI DFG+ ++ + D Sbjct: 171 EGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDS 230 Query: 496 --VTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQS 552 V+ + ++APE I Y D W++G+LL+E+ + G P+ G D F + Sbjct: 231 NYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYN 290 Query: 553 IME--HNVAYPKSMSKEAVAICKGLMTKHPGKR 583 ++ + +A P + E I P KR Sbjct: 291 KIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKR 323 >4Y83-A nrPDB Length = 332 Score = 68.9 bits (167), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 48/192 (25%), Positives = 88/192 (45%), Gaps = 10/192 (5%) Query: 350 KGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSC 409 +G+FGKV L++ T + A K++ D + DVE + + +L+ Sbjct: 83 RGAFGKVYLAQDIKTKKRMACKLIPVDQ-FKPSDVEIQACFRH--------ENIAELYGA 133 Query: 410 FQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKL 469 + ++ ME GG ++ ++ G +E ++ + GL FL SK +I+ D+K Sbjct: 134 VLWGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHHDIKP 193 Query: 470 DNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGV 529 N++ S + + DFG+ + D K GT Y++PE+I + + D ++ G Sbjct: 194 SNIVFMSTKAV-LVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILCRGHSTKADIYSLGA 252 Query: 530 LLYEMLAGQAPF 541 L M G P+ Sbjct: 253 TLIHMQTGTPPW 264 >1UA2-A nrPDB Length = 346 Score = 68.6 bits (166), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 60/203 (29%), Positives = 92/203 (45%), Gaps = 5/203 (2%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQ-DDDVECTMVEKRVLALPGKPPFLTQL 406 LG+G F V + K T+++ A+K +K + D + T + + L P + L Sbjct: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGL 77 Query: 407 HSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEP-HAVFYAAEIAIGLFFLQSKGIIYR 465 F + V +++ DL I+ P H Y GL +L I++R Sbjct: 78 LDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHR 136 Query: 466 DLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEII-AYQPYGKSVDW 524 DLK +N++LD G +K+ADFG+ K T Y APE++ + YG VD Sbjct: 137 DLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDM 196 Query: 525 WAFGVLLYEMLAGQAPFEGEDED 547 WA G +L E+L + PF D D Sbjct: 197 WAVGCILAELLL-RVPFLPGDSD 218 >4F0G-A nrPDB Length = 287 Score = 68.6 bits (166), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 58/213 (27%), Positives = 103/213 (48%), Gaps = 28/213 (13%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEK------RVLALPG-KP 400 +GKG FG V + A+K L ++ D + E M+EK V + Sbjct: 27 IGKGGFGLVHKGRLVKDKSVVAIKSL----ILGDSEGETEMIEKFQEFQREVFIMSNLNH 82 Query: 401 PFLTQLHSCFQTMDRLYFVMEYVNGGDLMYH--IQQVGRFKEPHAVFYAAEIAIGLFFLQ 458 P + +L+ R+ VME+V GDL YH + + K + +IA+G+ ++Q Sbjct: 83 PNIVKLYGLMHNPPRM--VMEFVPCGDL-YHRLLDKAHPIKWSVKLRLMLDIALGIEYMQ 139 Query: 459 SKG--IIYRDLKLDNVMLDSEGH-----IKIADFGMCKENIWDGVTTKTFCGTPDYIAPE 511 ++ I++RDL+ N+ L S K+ADFG+ ++++ + G ++APE Sbjct: 140 NQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQSVH---SVSGLLGNFQWMAPE 196 Query: 512 IIAYQ--PYGKSVDWWAFGVLLYEMLAGQAPFE 542 I + Y + D ++F ++LY +L G+ PF+ Sbjct: 197 TIGAEEESYTEKADTYSFAMILYTILTGEGPFD 229 >4QTB-A nrPDB Length = 380 Score = 68.2 bits (165), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 41/142 (28%), Positives = 76/142 (53%), Gaps = 8/142 (5%) Query: 408 SCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDL 467 S + M +Y V + + +Y + + + H ++ +I GL ++ S +++RDL Sbjct: 111 STLEAMRDVYIVQDLMETD--LYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDL 168 Query: 468 KLDNVMLDSEGHIKIADFGMCK----ENIWDGVTTKTFCGTPDYIAPEI-IAYQPYGKSV 522 K N+++++ +KI DFG+ + E+ G T+ + T Y APEI + + Y KS+ Sbjct: 169 KPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTE-YVATRWYRAPEIMLNSKGYTKSI 227 Query: 523 DWWAFGVLLYEMLAGQAPFEGE 544 D W+ G +L EML+ + F G+ Sbjct: 228 DIWSVGCILAEMLSNRPIFPGK 249 >2J0K-A nrPDB Length = 656 Score = 68.2 bits (165), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 60/241 (24%), Positives = 110/241 (45%), Gaps = 13/241 (5%) Query: 318 EEKTANTISKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDV 377 EE T S D R+R++L +G+G FG V + +K Sbjct: 373 EEDTYTMPSTRDYEIQRERIELGR-----CIGEGQFGDVHQGIYMSPENPAMAVAIKTCK 427 Query: 378 VIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR 437 D V +++ + P + +L T + ++ +ME G+L +Q V + Sbjct: 428 NCTSDSVREKFLQEALTMRQFDHPHIVKLIGVI-TENPVWIIMELCTLGELRSFLQ-VRK 485 Query: 438 FKEPHA--VFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDG 495 F A + YA +++ L +L+SK ++RD+ NV++ + +K+ DFG+ + + D Sbjct: 486 FSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSATDCVKLGDFGLSR-YMEDS 544 Query: 496 VTTKTFCGT--PDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQS 552 K G ++APE I ++ + + D W FGV ++E+L G PF+G +++ Sbjct: 545 TYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGR 604 Query: 553 I 553 I Sbjct: 605 I 605 >3N9X-A nrPDB Length = 432 Score = 68.2 bits (165), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 58/218 (26%), Positives = 98/218 (44%), Gaps = 33/218 (15%) Query: 347 VLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG-KPPFLTQ 405 ++G+GS+G V L+ K T++ A+K + + + +D ++C + + + L K ++ + Sbjct: 33 LIGRGSYGYVYLAYDKNTEKNVAIKKVNR---MFEDLIDCKRILREITILNRLKSDYIIR 89 Query: 406 LHSC-----FQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSK 460 L+ D LY V+E + DL + E H + +G F+ Sbjct: 90 LYDLIIPDDLLKFDELYIVLE-IADSDLKKLFKTPIFLTEEHIKTILYNLLLGENFIHES 148 Query: 461 GIIYRDLKLDNVMLDSEGHIKIADFGMCK---------------ENIWDGVTTKTF---- 501 GII+RDLK N +L+ + +K+ DFG+ + EN G K Sbjct: 149 GIIHRDLKPANCLLNQDCSVKVCDFGLARTINSEKDTNIVNDLEENEEPGPHNKNLKKQL 208 Query: 502 ---CGTPDYIAPEIIAYQP-YGKSVDWWAFGVLLYEML 535 T Y APE+I Q Y KS+D W+ G + E+L Sbjct: 209 TSHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAELL 246 >4AT3-A nrPDB Length = 299 Score = 67.8 bits (164), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 64/258 (24%), Positives = 109/258 (42%), Gaps = 26/258 (10%) Query: 348 LGKGSFGKVMLSE-----RKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPF 402 LG+G+FGKV L+E + L AVK LK D+ + L + Sbjct: 21 LGEGAFGKVFLAECYNLCPEQDKILVAVKTLKD----ASDNARKDFHREAELLTNLQHEH 76 Query: 403 LTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVG-------------RFKEPHAVFYAAE 449 + + + D L V EY+ GDL ++ G + + A + Sbjct: 77 IVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQ 136 Query: 450 IAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENI-WDGVTTKTFCGTP-DY 507 IA G+ +L S+ ++RDL N ++ +KI DFGM ++ D P + Sbjct: 137 IAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRW 196 Query: 508 IAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIMEHNVAY-PKSMS 565 + PE I Y+ + D W+ GV+L+E+ G+ P+ +E+ + I + V P++ Sbjct: 197 MPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCP 256 Query: 566 KEAVAICKGLMTKHPGKR 583 +E + G + P R Sbjct: 257 QEVYELMLGCWQREPHMR 274 >3PP0-A nrPDB Length = 338 Score = 67.8 bits (164), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 55/215 (25%), Positives = 106/215 (49%), Gaps = 12/215 (5%) Query: 337 MKLTDFNFLMVLGKGSFGKVM----LSERKGTDELYAVKILKKDVVIQDDDVECTMVEKR 392 +K T+ + VLG G+FG V + + + A+K+L+++ + + + + E Sbjct: 14 LKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKAN--KEILDEAY 71 Query: 393 VLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQ-VGRFKEPHAVFYAAEIA 451 V+A G P L C + +L V + + G L+ H+++ GR + + +IA Sbjct: 72 VMAGVGSPYVSRLLGICLTSTVQL--VTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIA 129 Query: 452 IGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTP--DYIA 509 G+ +L+ +++RDL NV++ S H+KI DFG+ + D G ++A Sbjct: 130 KGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMA 189 Query: 510 PEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEG 543 E I + + D W++GV ++E++ G P++G Sbjct: 190 LESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDG 224 >4MJJ-A nrPDB Length = 138 Score = 67.4 bits (163), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 37/90 (41%), Positives = 51/90 (56%), Gaps = 2/90 (2%) Query: 180 AKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESD--KD 237 AK L PMD NGL+DPYVKL L+P +K KTKT + +LNP WNE + D Sbjct: 34 AKGLKPMDFNGLADPYVKLHLLPGACKANKLKTKTQRNTLNPVWNEDLTYSGITDDDITH 93 Query: 238 RRLSVEIWDWDLTSRNDFMGSLSFGISELQ 267 + L + + D D S N+F+G + + L+ Sbjct: 94 KVLRIAVCDEDKLSHNEFIGEIRVPLRRLK 123 >2XS0-A nrPDB Length = 386 Score = 67.4 bits (163), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 43/143 (30%), Positives = 73/143 (51%), Gaps = 8/143 (5%) Query: 416 LYFVMEYVNGGDLMYHIQQVGRFKEPH--AVFYAAEIAIGLFFLQSKGIIYRDLKLDNVM 473 +Y VME ++ ++ QV + + H + ++ G+ L S GII+RDLK N++ Sbjct: 106 VYIVMELMDA-----NLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIV 160 Query: 474 LDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYE 533 + S+ +KI DFG+ + F T Y APE+I Y ++VD W+ G ++ E Sbjct: 161 VKSDCTLKILDFGLAR-TAGTSFMMVPFVVTRYYRAPEVILGMGYKENVDIWSVGCIMGE 219 Query: 534 MLAGQAPFEGEDEDELFQSIMEH 556 M+ G F G D + + ++E Sbjct: 220 MIKGGVLFPGTDHIDQWNKVIEQ 242 >3E7O-A nrPDB Length = 360 Score = 67.0 bits (162), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 42/143 (29%), Positives = 76/143 (53%), Gaps = 8/143 (5%) Query: 416 LYFVMEYVNGGDLMYHIQQVGRFKEPH--AVFYAAEIAIGLFFLQSKGIIYRDLKLDNVM 473 +Y VME ++ ++ QV + H + ++ G+ L S GII+RDLK N++ Sbjct: 102 VYLVMELMDA-----NLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIV 156 Query: 474 LDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYE 533 + S+ +KI DFG+ + + + T + T Y APE+I Y ++VD W+ G ++ E Sbjct: 157 VKSDCTLKILDFGLARTASTNFMMTP-YVVTRYYRAPEVILGMGYKENVDIWSVGCIMGE 215 Query: 534 MLAGQAPFEGEDEDELFQSIMEH 556 ++ G F+G D + + ++E Sbjct: 216 LVKGSVIFQGTDHIDQWNKVIEQ 238 >3VHK-A nrPDB Length = 368 Score = 67.0 bits (162), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 40/112 (35%), Positives = 63/112 (56%), Gaps = 3/112 (2%) Query: 442 HAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWD-GVTTKT 500 H + Y+ ++A G+ FL S+ I+RDL N++L + +KI DFG+ ++ D K Sbjct: 201 HLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKG 260 Query: 501 FCGTP-DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELF 550 P ++APE I + Y D W+FGVLL+E+ + G +P+ G DE F Sbjct: 261 DARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEF 312 >4PDO-A nrPDB Length = 299 Score = 67.0 bits (162), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 55/223 (24%), Positives = 101/223 (45%), Gaps = 26/223 (11%) Query: 347 VLGKGSFGKV---MLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFL 403 V+G G FG+V ML G KK+V + ++ EK+ + G+ + Sbjct: 41 VIGAGEFGEVYKGMLKTSSG----------KKEVPVAIKTLKAGYTEKQRVDFLGEAGIM 90 Query: 404 TQ--------LHSCFQTMDRLYFVMEYVNGGDLMYHIQQV-GRFKEPHAVFYAAEIAIGL 454 Q L + + EY+ G L +++ G F V IA G+ Sbjct: 91 GQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAGM 150 Query: 455 FFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTP---DYIAPE 511 +L + ++RDL N++++S K++DFG+ + D T T G + APE Sbjct: 151 KYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPE 210 Query: 512 IIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSI 553 I+Y+ + + D W+FG++++E++ G+ P+ E+ ++I Sbjct: 211 AISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAI 253 >6FER-A nrPDB Length = 309 Score = 66.6 bits (161), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 64/242 (26%), Positives = 109/242 (45%), Gaps = 41/242 (16%) Query: 348 LGKGSFGKVMLSERKGTDE----------------LYAVKILKKDVVIQDDDVECTMVEK 391 LG+G FG+V L E +G ++ L AVK+L+ D + + E Sbjct: 17 LGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADA--NKNARNDFLKEI 74 Query: 392 RVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAV------- 444 ++++ P + L C T D L + EY+ GDL Q + R + P++ Sbjct: 75 KIMSRLKDPNIIHLLAVCI-TDDPLCMITEYMENGDLN---QFLSRHEPPNSSSSDVRTV 130 Query: 445 ------FYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDG--V 496 F A +IA G+ +L S ++RDL N ++ IKIADFGM + N++ G Sbjct: 131 SYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSR-NLYSGDYY 189 Query: 497 TTKTFCGTP-DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA--GQAPFEGEDEDELFQSI 553 + P +++ E I + + D WAFGV L+E + P+ ++++ ++ Sbjct: 190 RIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIENT 249 Query: 554 ME 555 E Sbjct: 250 GE 251 >2PMN-X nrPDB Length = 348 Score = 66.6 bits (161), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 61/290 (21%), Positives = 121/290 (41%), Gaps = 48/290 (16%) Query: 339 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA--- 395 + D+ + L +G F K++L E+ ++ YA+K +K ++ + D + +K + Sbjct: 30 INDYRIIRTLNQGKFNKIILCEK--DNKFYALKKYEKSLLEKKRDFTKSNNDKISIKSKY 87 Query: 396 --LPGKPPFLTQLHS--------CFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVF 445 + +T + + D +Y + EY+ ++ + + + F Sbjct: 88 DDFKNELQIITDIKNEYCLTCEGIITNYDEVYIIYEYMENDSILKFDEYFFVLDKNYTCF 147 Query: 446 YAAEIAIGL---------FFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGV 496 ++ + + K I +RD+K N+++D G +K++DFG + + + Sbjct: 148 IPIQVIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMDKNGRVKLSDFGESEYMVDKKI 207 Query: 497 TTKTFCGTPDYIAPEIIAYQPY--GKSVDWWAFGVLLYEMLAGQAPFEGE-DEDELFQSI 553 K GT +++ PE + + G VD W+ G+ LY M PF + ELF +I Sbjct: 208 --KGSRGTYEFMPPEFFSNESSYNGAKVDIWSLGICLYVMFYNVVPFSLKISLVELFNNI 265 Query: 554 MEHNVAYP-------------KS------MSKEAVAICKGLMTKHPGKRL 584 N+ YP KS +S E + K + K+P +R+ Sbjct: 266 RTKNIEYPLDRNHFLYPLTNKKSTCSNNFLSNEDIDFLKLFLRKNPAERI 315 >5AWM-A nrPDB Length = 394 Score = 66.6 bits (161), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 45/147 (30%), Positives = 74/147 (50%), Gaps = 18/147 (12%) Query: 416 LYFVMEYVNGGDLMYHIQQVGRFKEPH--AVFYAAEIAIGLFFLQSKGIIYRDLKLDNVM 473 +Y VME ++ ++ QV + H + ++ G+ L S GII+RDLK N++ Sbjct: 124 VYLVMELMDA-----NLCQVIQMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIV 178 Query: 474 LDSEGHIKIADFGMCKENIWDGVTTKTFCGTPD-----YIAPEIIAYQPYGKSVDWWAFG 528 + ++ +KI DFG+ + TF TP Y APE+I Y ++VD W+ G Sbjct: 179 VKADCTLKILDFGLAR------TAGTTFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVG 232 Query: 529 VLLYEMLAGQAPFEGEDEDELFQSIME 555 ++ EM+ G F G D + + I+E Sbjct: 233 CIMGEMIRGGVLFPGTDHIDQWNKIIE 259 >1XA6-A nrPDB Length = 466 Score = 66.6 bits (161), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 29/81 (35%), Positives = 51/81 (62%), Gaps = 8/81 (9%) Query: 102 HKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGR 161 H FK+HT+ P +C++C + ++GLI QG++C C +NVHK+C +VP+ C D +R + Sbjct: 213 HNFKVHTFRGPHWCEYCANFMWGLIAQGVRCSDCGLNVHKQCSKHVPNDCQPD-LKRIKK 271 Query: 162 IY-------IQAHIDREVLIV 175 +Y ++AH + ++V Sbjct: 272 VYCCDLTTLVKAHNTQRPMVV 292 Score = 55.8 bits (133), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 25/74 (33%), Positives = 35/74 (47%), Gaps = 2/74 (2%) Query: 15 ESTVRFARKGALRQKNVH--EVKNHKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCF 72 E R+ AL + H K H F F+ P +C +C +F+WG QG +C C Sbjct: 189 EKISSLVRRAALTHNDNHFNYEKTHNFKVHTFRGPHWCEYCANFMWGLIAQGVRCSDCGL 248 Query: 73 VVHKRCHEFVTFSC 86 VHK+C + V C Sbjct: 249 NVHKQCSKHVPNDC 262 >5EFQ-A nrPDB Length = 347 Score = 66.6 bits (161), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 49/218 (22%), Positives = 105/218 (48%), Gaps = 16/218 (7%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKD--------VVIQDDDVECTMVEKRV 393 F+ + ++G+G++G+V + K T E+ A+K ++ D I++ + + + + Sbjct: 13 FDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSI 72 Query: 394 LALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQ-VGRFKEPHAVFYAAEIAI 452 + + + Y V EY++ DLM ++ + F E H + ++ Sbjct: 73 INMKEIVTDKEDALDFKKDKGAFYLVFEYMD-HDLMGLLESGLVHFNENHIKSFMRQLME 131 Query: 453 GLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCG---TPDYIA 509 GL + K ++RD+K N++L++ G IK+ADFG+ + ++ ++ + T Y Sbjct: 132 GLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLAR--LYSSEESRPYTNKVITLWYRP 189 Query: 510 PE-IIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDE 546 PE ++ + Y ++D W+ G +L E+ + F+ E Sbjct: 190 PELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQE 227 >4IC8-A nrPDB Length = 442 Score = 66.6 bits (161), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 55/225 (24%), Positives = 102/225 (45%), Gaps = 14/225 (6%) Query: 341 DFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKK--DVVIQDDDVECTMVEKRVLALPG 398 ++ + +G G++G V + R+ T + A+K + DVV + + T+ E ++L Sbjct: 56 EYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVT---NAKRTLRELKILKHFK 112 Query: 399 KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEP----HAVFYAAEIAIGL 454 + T+ F YV + + Q+ +P H ++ ++ GL Sbjct: 113 HDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGL 172 Query: 455 FFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGM----CKENIWDGVTTKTFCGTPDYIAP 510 ++ S +I+RDLK N++++ +KI DFGM C + T Y AP Sbjct: 173 KYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAP 232 Query: 511 EI-IAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIM 554 E+ ++ Y +++D W+ G + EMLA + F G++ Q IM Sbjct: 233 ELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIM 277 >1DQV-A nrPDB Length = 296 Score = 66.6 bits (161), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 38/110 (34%), Positives = 57/110 (51%), Gaps = 1/110 (0%) Query: 172 VLIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQL 231 +L V + A NL MD G SDPYVK LI + + K+KT K +LNP +NE F + Sbjct: 153 LLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKKNTLNPTYNEALVFDV 212 Query: 232 K-ESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKAGVDGWFKLLSQ 280 ES ++ LS+ + D+D N+ +G G G + W ++L+ Sbjct: 213 APESVENVGLSIAVVDYDCIGHNEVIGVCRVGPEAADPHGREHWAEMLAN 262 Score = 65.1 bits (157), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 36/88 (40%), Positives = 56/88 (63%), Gaps = 3/88 (3%) Query: 173 LIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLK 232 L+V + A +L D NG SDPYVK+ L+PD K K +TK + +LNP +NETF+F + Sbjct: 22 LVVRILQALDLPAKDSNGFSDPYVKIYLLPDRK--KKFQTKVHRKTLNPIFNETFQFSVP 79 Query: 233 ESD-KDRRLSVEIWDWDLTSRNDFMGSL 259 ++ R+L ++D+D SR+D +G + Sbjct: 80 LAELAQRKLHFSVYDFDRFSRHDLIGQV 107 >1G3N-A nrPDB Length = 326 Score = 66.2 bits (160), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 42/143 (29%), Positives = 69/143 (48%), Gaps = 4/143 (2%) Query: 415 RLYFVMEYVNGGDLMYHIQQVGRFKEPHAVF--YAAEIAIGLFFLQSKGIIYRDLKLDNV 472 +L V E+V+ DL ++ +V P ++ GL FL S +++RDLK N+ Sbjct: 93 KLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNI 151 Query: 473 MLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLY 532 ++ S G IK+ADFG+ + + T T Y APE++ Y VD W+ G + Sbjct: 152 LVTSSGQIKLADFGLARIYSFQMALTSVVV-TLWYRAPEVLLQSSYATPVDLWSVGCIFA 210 Query: 533 EMLAGQAPFEGEDEDELFQSIME 555 EM + F G + + I++ Sbjct: 211 EMFRRKPLFRGSSDVDQLGKILD 233 >5NGU-A nrPDB Length = 381 Score = 66.2 bits (160), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 54/215 (25%), Positives = 104/215 (48%), Gaps = 20/215 (9%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVEC--TMVEKRVLALPGK 399 + L +G+G++G V D L V++ K + + C T+ E ++L L + Sbjct: 44 YTNLSYIGEGAYGMVC----SAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKIL-LRFR 98 Query: 400 PPFLTQLHSCFQT-----MDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGL 454 + ++ + M +Y V + + +Y + + H ++ +I GL Sbjct: 99 HENIIGINDIIRAPTIEQMKDVYIVQDLMETD--LYKLLKTQHLSNDHICYFLYQILRGL 156 Query: 455 FFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCK----ENIWDGVTTKTFCGTPDYIAP 510 ++ S +++RDLK N++L++ +KI DFG+ + ++ G T+ + T Y AP Sbjct: 157 KYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTE-YVATRWYRAP 215 Query: 511 EI-IAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGE 544 EI + + Y KS+D W+ G +L EML+ + F G+ Sbjct: 216 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGK 250 >1LUF-A nrPDB Length = 343 Score = 66.2 bits (160), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 64/282 (22%), Positives = 116/282 (41%), Gaps = 46/282 (16%) Query: 340 TDFNFLMVLGKGSFGKVMLSERKGTD-----ELYAVKILKKDVVIQDDDVECTMVEKRVL 394 + ++ +G+G+FG+V + G + AVK+LK++ D++ + L Sbjct: 47 NNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEA---SADMQADFQREAAL 103 Query: 395 ALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVF--------- 445 P + +L + + EY+ GDL + R PH V Sbjct: 104 MAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDL----NEFLRSMSPHTVCSLSHSDLST 159 Query: 446 -------------------YAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFG 486 A ++A G+ +L + ++RDL N ++ +KIADFG Sbjct: 160 RARVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFG 219 Query: 487 MCKENIWDGVTTKTFCGTP---DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFE 542 + + NI+ K ++ PE I Y Y D WA+GV+L+E+ + G P+ Sbjct: 220 LSR-NIYSADYYKADGNDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYY 278 Query: 543 GEDEDELFQSIMEHNV-AYPKSMSKEAVAICKGLMTKHPGKR 583 G +E+ + + N+ A P++ E + + +K P R Sbjct: 279 GMAHEEVIYYVRDGNILACPENCPLELYNLMRLCWSKLPADR 320 >4MYG-A nrPDB Length = 372 Score = 66.2 bits (160), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 39/118 (33%), Positives = 68/118 (57%), Gaps = 5/118 (4%) Query: 438 FKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVT 497 F E + ++ GL ++ S G+++RDLK N+ ++ + +KI DFG+ + D Sbjct: 142 FSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA--DAEM 199 Query: 498 TKTFCGTPDYIAPEII-AYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDE-DELFQSI 553 T + T Y APE+I ++ Y ++VD W+ G ++ EML G+ F+G+D D+L Q + Sbjct: 200 T-GYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQIL 256 >1V0B-A nrPDB Length = 288 Score = 66.2 bits (160), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 50/211 (23%), Positives = 104/211 (49%), Gaps = 12/211 (5%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 407 +G+G++G V+ + E +A+K ++ + +D+ + T + + + K + +L+ Sbjct: 10 IGEGTYG-VVYKAQNNYGETFALKKIRLEK--EDEGIPSTTIREISILKELKHSNIVKLY 66 Query: 408 SCFQTMDRLYFVMEYVNGGDLMYHIQQV-GRFKEPHAVFYAAEIAIGLFFLQSKGIIYRD 466 T RL V E+++ DL + G + A + ++ G+ + + +++RD Sbjct: 67 DVIHTKKRLVLVFEHLDQ-DLKKLLDVCEGGLESVTAKSFLLQLLNGIAYCHDRRVLHRD 125 Query: 467 LKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCG---TPDYIAPEII-AYQPYGKSV 522 LK N++++ EG +KIADFG+ + G+ + + T Y AP+++ + Y ++ Sbjct: 126 LKPQNLLINREGELKIADFGLARAF---GIPVRKYTHEVVTLWYRAPDVLMGSKKYSTTI 182 Query: 523 DWWAFGVLLYEMLAGQAPFEGEDEDELFQSI 553 D W+ G + EM+ G F G E + I Sbjct: 183 DIWSVGCIFAEMVNGAPLFPGVSEADQLMRI 213 >4EBW-A nrPDB Length = 304 Score = 65.9 bits (159), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 42/147 (28%), Positives = 79/147 (53%), Gaps = 7/147 (4%) Query: 412 TMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHA--VFYAAEIAIGLFFLQSKGIIYRDLKL 469 T + ++ +ME G+L +Q V ++ A + YA +++ L +L+SK ++RD+ Sbjct: 109 TENPVWIIMELCTLGELRSFLQ-VRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAA 167 Query: 470 DNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGT--PDYIAPEIIAYQPYGKSVDWWAF 527 NV++ S +K+ DFG+ + + D K G ++APE I ++ + + D W F Sbjct: 168 RNVLVSSNDCVKLGDFGLSR-YMEDSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMF 226 Query: 528 GVLLYEMLA-GQAPFEGEDEDELFQSI 553 GV ++E+L G PF+G +++ I Sbjct: 227 GVCMWEILMHGVKPFQGVKNNDVIGRI 253 >4JLC-A nrPDB Length = 657 Score = 65.9 bits (159), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 55/217 (25%), Positives = 94/217 (43%), Gaps = 31/217 (14%) Query: 347 VLGKGSFGKVMLSERKGTDELYAVKILKK-------DVVIQDDDVECTMVEKRVLALPGK 399 +LG+G+ V K T +LYAVK+ DV +++ +V + K ++ L Sbjct: 15 ILGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAI 74 Query: 400 PPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQ-VGRFKEPHAVFYAA--EIAIGLFF 456 T H +ME+ G L +++ + P + F ++ G+ Sbjct: 75 EEETTTRHKVL--------IMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 126 Query: 457 LQSKGIIYRDLKLDNVML----DSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEI 512 L+ GI++RD+K N+M D + K+ DFG +E + D + GT +Y+ P++ Sbjct: 127 LRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARE-LEDDEQFVSLYGTEEYLHPDM 185 Query: 513 IA--------YQPYGKSVDWWAFGVLLYEMLAGQAPF 541 + YG +VD W+ GV Y G PF Sbjct: 186 YERAVLRKDHQKKYGATVDLWSVGVTFYHAATGSLPF 222 >5GNK-A nrPDB Length = 297 Score = 65.9 bits (159), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 60/237 (25%), Positives = 116/237 (48%), Gaps = 19/237 (8%) Query: 337 MKLTDFNFLMVLGKGSFGKVM----LSERKGTDELYAVKILKKDVVIQDDDVECTMVEKR 392 +K T+F + VLG G+FG V + E + A+K L++ + + + + E Sbjct: 16 LKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKAN--KEILDEAY 73 Query: 393 VLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQ-VGRFKEPHAVFYAAEIA 451 V+A P L C + +L +M+ + G L+ ++++ + + + +IA Sbjct: 74 VMASVDNPHVCRLLGICLTSTVQL--IMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIA 131 Query: 452 IGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCG----TP-D 506 G+ +L+ + +++RDL NV++ + H+KI DFG+ K G K + P Sbjct: 132 KGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAK---LLGAEEKEYHAEGGKVPIK 188 Query: 507 YIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIMEHNVAYPK 562 ++A E I ++ Y D W++GV ++E++ G P++G E+ SI+E P+ Sbjct: 189 WMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEI-SSILEKGERLPQ 244 >1ZXE-A nrPDB Length = 303 Score = 65.9 bits (159), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 60/284 (21%), Positives = 128/284 (45%), Gaps = 48/284 (16%) Query: 340 TDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK 399 +DF + VLG+G+FG+V+ + YA+K ++ ++ T++ + +L Sbjct: 6 SDFEEIAVLGQGAFGQVVKARNALDSRYYAIKKIR-----HTEEKLSTILSEVMLLASLN 60 Query: 400 PPFLTQLHSCF-------------QTMDRLYFVMEYVNGGDL--MYHIQQVGRFKEPHAV 444 ++ + ++ + + L+ MEY L + H + + + ++ + Sbjct: 61 HQYVVRYYAAWLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQRDEYWR 120 Query: 445 FYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCK-------------EN 491 + +I L ++ S+GII+R+LK N+ +D ++KI DFG+ K +N Sbjct: 121 LFR-QILEALSYIHSQGIIHRNLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKLDSQN 179 Query: 492 I---WDGVTTKTFCGTPDYIAPEII-AYQPYGKSVDWWAFGVLLYEMLAGQAPFE-GEDE 546 + D +T+ GT Y+A E++ Y + +D ++ G++ +EM+ PF G + Sbjct: 180 LPGSSDNLTSA--IGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMI---YPFSTGMER 234 Query: 547 DELFQSIMEHNVAYPKSMSKEAV----AICKGLMTKHPGKRLGC 586 + + + ++ +P + I + L+ P KR G Sbjct: 235 VNILKKLRSVSIEFPPDFDDNKMKVEKKIIRLLIDHDPNKRPGA 278 >3CXL-A nrPDB Length = 463 Score = 65.9 bits (159), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 25/53 (47%), Positives = 37/53 (69%) Query: 102 HKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTD 154 H FK+HT+ P +C++C + ++GLI QG+KC C +NVHK+C VP+ C D Sbjct: 210 HNFKVHTFRGPHWCEYCANFMWGLIAQGVKCADCGLNVHKQCSKMVPNDCKPD 262 Score = 54.3 bits (129), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 30/108 (27%), Positives = 45/108 (41%), Gaps = 16/108 (14%) Query: 35 KNHKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPA 94 K H F F+ P +C +C +F+WG QG +C C VHK+C + V C Sbjct: 208 KIHNFKVHTFRGPHWCEYCANFMWGLIAQGVKCADCGLNVHKQCSKMVPNDC-------- 259 Query: 95 SDDPRSKHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKR 142 P KH K+++ CD + + M D C+ + R Sbjct: 260 --KPDLKHVKKVYS------CDLTTLVKAHTTKRPMVVDMCIREIESR 299 >3ALO-A nrPDB Length = 327 Score = 65.9 bits (159), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 54/210 (25%), Positives = 98/210 (46%), Gaps = 12/210 (5%) Query: 341 DFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKP 400 D L +G+G++G V K + ++ AVK ++ V + + + +++ V+ Sbjct: 23 DLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTV--DEKEQKQLLMDLDVVMRSSDC 80 Query: 401 PFLTQLHSCFQTMDRLYFVMEYVNGG-DLMY-HIQQVGRFKEPHAVFYAAEIAI--GLFF 456 P++ Q + + ME ++ D Y ++ V P + +A L Sbjct: 81 PYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNH 140 Query: 457 LQSK-GIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEII-- 513 L+ II+RD+K N++LD G+IK+ DFG+ + + D + G Y+APE I Sbjct: 141 LKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLV-DSIAKTRDAGCRPYMAPERIDP 199 Query: 514 --AYQPYGKSVDWWAFGVLLYEMLAGQAPF 541 + Q Y D W+ G+ LYE+ G+ P+ Sbjct: 200 SASRQGYDVRSDVWSLGITLYELATGRFPY 229 >5O0Y-A nrPDB Length = 579 Score = 65.9 bits (159), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 55/175 (31%), Positives = 84/175 (48%), Gaps = 20/175 (11%) Query: 401 PFLTQLHSCFQT-MDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQS 459 P + +L+ F D V+EY G DL ++++Q E A +I L +L Sbjct: 348 PRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNE 407 Query: 460 KG--IIYRDLKLDNVML---DSEGHIKIADFGMCK------ENIWDGVT-TKTFCGTPDY 507 II+ DLK N++L + G IKI DFG+ K N DG+ T GT Y Sbjct: 408 IKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWY 467 Query: 508 IAPE--IIAYQP--YGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNV 558 + PE ++ +P VD W+ GV+ Y+ L G+ PF G ++ + Q I++ N Sbjct: 468 LPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPF-GHNQSQ--QDILQENT 519 >3DKO-A nrPDB Length = 318 Score = 65.9 bits (159), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 57/218 (26%), Positives = 103/218 (47%), Gaps = 13/218 (5%) Query: 347 VLGKGSFGKVMLSERK---GTDELYAVKILKKDVV-IQDDDVECTMVEKRVLALPGKPPF 402 V+G G FG+V K D A+K LK Q D C E ++ P Sbjct: 50 VIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLC---EASIMGQFDHPN- 105 Query: 403 LTQLHSCFQTMDRLYFVMEYVNGGDL-MYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKG 461 + L + V+E++ G L + + G+F V IA G+ +L G Sbjct: 106 VVHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGMRYLADMG 165 Query: 462 IIYRDLKLDNVMLDSEGHIKIADFGMCK--ENIWDGVTTKTFCGTP-DYIAPEIIAYQPY 518 ++RDL N++++S K++DFG+ + E+ + V T T P + APE I Y+ + Sbjct: 166 YVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRKF 225 Query: 519 GKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIME 555 + D W++G++++E+++ G+ P+ ++ ++I E Sbjct: 226 TSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEE 263 >4LRM-A nrPDB Length = 334 Score = 65.5 bits (158), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 61/240 (25%), Positives = 117/240 (48%), Gaps = 22/240 (9%) Query: 337 MKLTDFNFLMVLGKGSFGKVM----LSERKGTDELYAVKILKKDVVIQDDDVECTMVEKR 392 +K T+F + VLG G+FG V + E + A+K L++ + + + + E Sbjct: 16 LKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKAN--KEILDEAY 73 Query: 393 VLAL---PGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQ-VGRFKEPHAVFYAA 448 V+A PG P L C + +L + + + G L+ ++++ + + + Sbjct: 74 VMASVDNPGNPHVCRLLGICLTSTVQL--ITQLMPFGCLLDYVREHKDNIGSQYLLNWCV 131 Query: 449 EIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCG----T 504 +IA G+ +L+ + +++RDL NV++ + H+KI DFG+ K G K + Sbjct: 132 QIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAK---LLGAEEKEYHAEGGKV 188 Query: 505 P-DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIMEHNVAYPK 562 P ++A E I ++ Y D W++GV ++E++ G P++G E+ SI+E P+ Sbjct: 189 PIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEI-SSILEKGERLPQ 247 >4ZSG-A nrPDB Length = 347 Score = 65.5 bits (158), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 55/225 (24%), Positives = 102/225 (45%), Gaps = 14/225 (6%) Query: 341 DFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKK--DVVIQDDDVECTMVEKRVLALPG 398 ++ + +G G++G V + R+ T + A+K + DVV + + T+ E ++L Sbjct: 8 EYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVV---TNAKRTLRELKILKHFK 64 Query: 399 KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEP----HAVFYAAEIAIGL 454 + T+ F YV + + Q+ +P H ++ ++ GL Sbjct: 65 HDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGL 124 Query: 455 FFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGM----CKENIWDGVTTKTFCGTPDYIAP 510 ++ S +I+RDLK N++++ +KI DFGM C + T Y AP Sbjct: 125 KYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAP 184 Query: 511 EI-IAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIM 554 E+ ++ Y +++D W+ G + EMLA + F G++ Q IM Sbjct: 185 ELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIM 229 >3NIE-A nrPDB Length = 429 Score = 65.5 bits (158), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 56/223 (25%), Positives = 98/223 (43%), Gaps = 40/223 (17%) Query: 347 VLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG-KPPFLTQ 405 ++G+GS+G V L+ K ++ A+K + + + +D ++C + + + L K ++ + Sbjct: 35 LIGRGSYGYVYLAYDKNANKNVAIKKVNR---MFEDLIDCKRILREITILNRLKSDYIIR 91 Query: 406 LHSC-----FQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSK 460 LH D LY V+E + DL + E H + +G F+ Sbjct: 92 LHDLIIPEDLLKFDELYIVLE-IADSDLKKLFKTPIFLTEQHVKTILYNLLLGEKFIHES 150 Query: 461 GIIYRDLKLDNVMLDSEGHIKIADFGMCK---------------------------ENIW 493 GII+RDLK N +L+ + +KI DFG+ + +N+ Sbjct: 151 GIIHRDLKPANCLLNQDCSVKICDFGLARTINSDKDIHIVNDLEEKEENEEPGPHNKNLK 210 Query: 494 DGVTTKTFCGTPDYIAPEIIAYQP-YGKSVDWWAFGVLLYEML 535 +T+ T Y APE+I Q Y S+D W+ G + E+L Sbjct: 211 KQLTSHVV--TRWYRAPELILLQENYTNSIDIWSTGCIFAELL 251 >4H1J-A nrPDB Length = 293 Score = 65.5 bits (158), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 49/204 (24%), Positives = 103/204 (50%), Gaps = 16/204 (7%) Query: 347 VLGKGSFGKV---MLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFL 403 +LG+G FG+V + + KG AVK KKD + + + + + V+ P + Sbjct: 31 ILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKE---KFMSEAVIMKNLDHPHI 87 Query: 404 TQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQ-VGRFKEPHAVFYAAEIAIGLFFLQSKGI 462 +L + + + +ME G+L +++++ K V Y+ +I + +L+S Sbjct: 88 VKLIGIIEE-EPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINC 146 Query: 463 IYRDLKLDNVMLDSEGHIKIADFGMCK----ENIWDGVTTKTFCGTPDYIAPEIIAYQPY 518 ++RD+ + N+++ S +K+ DFG+ + E+ + T+ +++PE I ++ + Sbjct: 147 VHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRL---PIKWMSPESINFRRF 203 Query: 519 GKSVDWWAFGVLLYEMLA-GQAPF 541 + D W F V ++E+L+ G+ PF Sbjct: 204 TTASDVWMFAVCMWEILSFGKQPF 227 >3HNG-A nrPDB Length = 360 Score = 65.1 bits (157), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 43/140 (30%), Positives = 68/140 (48%), Gaps = 27/140 (19%) Query: 436 GRFKEP----HAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKEN 491 G +KEP + Y+ ++A G+ FL S+ I+RDL N++L +KI DFG+ ++ Sbjct: 190 GFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARD- 248 Query: 492 IWDGVTTKTFCGTPDYI------------APEIIAYQPYGKSVDWWAFGVLLYEMLA-GQ 538 PDY+ APE I + Y D W++GVLL+E+ + G Sbjct: 249 ---------IYKNPDYVRKGDTRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGG 299 Query: 539 APFEGEDEDELFQSIMEHNV 558 +P+ G DE F S + + Sbjct: 300 SPYPGVQMDEDFCSRLREGM 319 Score = 30.4 bits (67), Expect = 2.4, Method: Compositional matrix adjust. Identities = 29/107 (27%), Positives = 50/107 (46%), Gaps = 13/107 (12%) Query: 334 RDRMKLTDFNFLMVLGKGSFGKVMLSERKG-----TDELYAVKILKKDVVIQDDDVECTM 388 R+R+KL LG+G+FGKV+ + G T AVK+LK+ + + M Sbjct: 26 RERLKLGK-----SLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATAS--EYKALM 78 Query: 389 VEKRVLALPGKP-PFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQ 434 E ++L G + L +C + L ++EY G+L +++ Sbjct: 79 TELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKS 125 >3BBT-B nrPDB Length = 328 Score = 65.1 bits (157), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 59/227 (25%), Positives = 104/227 (45%), Gaps = 22/227 (9%) Query: 330 NNGNRDRMKLTDFNFLMVLGKGSFGKVM----LSERKGTDELYAVKILKKDVVIQDDDVE 385 N +K T+ + VLG G+FG V + E + A+KIL + +VE Sbjct: 5 NQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILN-ETTGPKANVE 63 Query: 386 CTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQ-VGRFKEPHAV 444 M E ++A P + L C +L V + + G L+ ++ + + Sbjct: 64 F-MDEALIMASMDHPHLVRLLGVCLSPTIQL--VTQLMPHGCLLEYVHEHKDNIGSQLLL 120 Query: 445 FYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMC-------KENIWDGVT 497 + +IA G+ +L+ + +++RDL NV++ S H+KI DFG+ KE DG Sbjct: 121 NWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGK 180 Query: 498 TKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEG 543 ++A E I Y+ + D W++GV ++E++ G P++G Sbjct: 181 MPI-----KWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDG 222 >3G0E-A nrPDB Length = 336 Score = 65.1 bits (157), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 69/270 (25%), Positives = 113/270 (41%), Gaps = 30/270 (11%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDE-----LYAVKILKKDVVIQDDDVECTMVEKRVLAL 396 +F LG G+FGKV+ + G + AVK+LK + + E M E +VL+ Sbjct: 48 LSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTER--EALMSELKVLSY 105 Query: 397 PGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQ-----VGRFKEPHAVF------ 445 G + L + EY GDL+ +++ + P + Sbjct: 106 LGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKTSPAIMEDDELAL 165 Query: 446 -------YAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDG-VT 497 ++ ++A G+ FL SK I+RDL N++L KI DFG+ ++ D Sbjct: 166 DLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYV 225 Query: 498 TKTFCGTP-DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIME 555 K P ++APE I Y D W++G+ L+E+ + G +P+ G D F +++ Sbjct: 226 VKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIK 285 Query: 556 HN--VAYPKSMSKEAVAICKGLMTKHPGKR 583 + P+ E I K P KR Sbjct: 286 EGFRMLSPEHAPAEMYDIMKTCWDADPLKR 315 >2Y6O-A nrPDB Length = 291 Score = 65.1 bits (157), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 54/217 (24%), Positives = 101/217 (46%), Gaps = 11/217 (5%) Query: 347 VLGKGSFGKVMLSERK--GTDEL-YAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFL 403 V+G G FG+V K G E+ A+K LK D + E ++ P + Sbjct: 21 VIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYT--DKQRRDFLSEASIMGQFDHPNII 78 Query: 404 TQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQV-GRFKEPHAVFYAAEIAIGLFFLQSKGI 462 L + + EY+ G L +++ GRF V I G+ +L Sbjct: 79 -HLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYLSDMSY 137 Query: 463 IYRDLKLDNVMLDSEGHIKIADFGMCK---ENIWDGVTTKTFCGTPDYIAPEIIAYQPYG 519 ++RDL N++++S K++DFGM + ++ TT+ + APE IAY+ + Sbjct: 138 VHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRKFT 197 Query: 520 KSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIME 555 + D W++G++++E+++ G+ P+ ++ ++I E Sbjct: 198 SASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEE 234 >6ANJ-A nrPDB Length = 148 Score = 64.7 bits (156), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 45/126 (35%), Positives = 69/126 (54%), Gaps = 6/126 (4%) Query: 157 ERRGRIYIQA--HIDREVLIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKT 214 E GRI + L V V A+ L D +G SDP+VK+ L+PD K K +TK Sbjct: 20 ENLGRIQFSVGYNFQESTLTVKVMKAQELPAKDFSGTSDPFVKIYLLPDKK--HKLETKV 77 Query: 215 IKCSLNPEWNETFRFQLKESDK--DRRLSVEIWDWDLTSRNDFMGSLSFGISELQKAGVD 272 + +LNP WNETF F+ +K R L +++ D+D SRND +G +S ++++ + Sbjct: 78 KRKNLNPHWNETFLFEGFPYEKVVQRILYLQVLDYDRFSRNDPIGEVSIPLNKVDLTQMQ 137 Query: 273 GWFKLL 278 ++K L Sbjct: 138 TFWKDL 143 >3LMG-A nrPDB Length = 344 Score = 64.7 bits (156), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 63/242 (26%), Positives = 109/242 (45%), Gaps = 34/242 (14%) Query: 317 PEEKTANTISKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGT--DELYAVKILK 374 P EK +++ K T+ L VLG G FG V KG E ++KI Sbjct: 16 PSEKANKVLARI--------FKETELRKLKVLGSGVFGTV----HKGVWIPEGESIKIPV 63 Query: 375 KDVVIQDDDVECTM--VEKRVLALPG--KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMY 430 VI+D + V +LA+ + L C + L V +Y+ G L+ Sbjct: 64 CIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVRLLGLCPGS--SLQLVTQYLPLGSLLD 121 Query: 431 HIQQVGRFKEPHAVF-YAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMC- 488 H++Q P + + +IA G+++L+ G+++R+L NV+L S +++ADFG+ Sbjct: 122 HVRQHRGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVAD 181 Query: 489 ------KENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPF 541 K+ ++ T ++A E I + Y D W++GV ++E++ G P+ Sbjct: 182 LLPPDDKQLLYSEAKTPI-----KWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEPY 236 Query: 542 EG 543 G Sbjct: 237 AG 238 >5AMN-A nrPDB Length = 299 Score = 64.7 bits (156), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 64/256 (25%), Positives = 115/256 (44%), Gaps = 24/256 (9%) Query: 348 LGKGSFGKVM------LSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 LG+G FGKV+ L R G + AVK+LK++ ++ + E VL P Sbjct: 31 LGEGEFGKVVKATAFHLKGRAGYTTV-AVKMLKENA--SPSELRDLLSEFNVLKQVNHPH 87 Query: 402 FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPH----------AVFYAAEIA 451 + +C Q L ++EY G L +++ + + + +A +I+ Sbjct: 88 VIKLYGACSQD-GPLLLIVEYAKYGSLRGFLRESRKVGPGYPDERALTMGDLISFAWQIS 146 Query: 452 IGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGT--PDYIA 509 G+ +L +++RDL N+++ +KI+DFG+ ++ + K G ++A Sbjct: 147 QGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMA 206 Query: 510 PEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIME-HNVAYPKSMSKE 567 E + Y D W+FGVLL+E++ G P+ G + LF + H + P + S+E Sbjct: 207 IESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEE 266 Query: 568 AVAICKGLMTKHPGKR 583 + + P KR Sbjct: 267 MYRLMLQCWKQEPDKR 282 >3NIZ-A nrPDB Length = 311 Score = 64.3 bits (155), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 49/207 (23%), Positives = 99/207 (47%), Gaps = 11/207 (5%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 407 +G+G++G V+ + + A+K ++ D +D+ + T + + L P + L Sbjct: 29 VGEGTYG-VVYKAKDSQGRIVALKRIRLDA--EDEGIPSTAIREISLLKELHHPNIVSLI 85 Query: 408 SCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDL 467 + L V E++ + ++ Y ++ G+ I++RDL Sbjct: 86 DVIHSERCLTLVFEFMEKDLKKVLDENKTGLQDSQIKIYLYQLLRGVAHCHQHRILHRDL 145 Query: 468 KLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCG---TPDYIAPEII-AYQPYGKSVD 523 K N++++S+G +K+ADFG+ + G+ +++ T Y AP+++ + Y SVD Sbjct: 146 KPQNLLINSDGALKLADFGLARAF---GIPVRSYTHEVVTLWYRAPDVLMGSKKYSTSVD 202 Query: 524 WWAFGVLLYEMLAGQAPFEG-EDEDEL 549 W+ G + EM+ G+ F G D+D+L Sbjct: 203 IWSIGCIFAEMITGKPLFPGVTDDDQL 229 >2D8K-A nrPDB Length = 141 Score = 64.3 bits (155), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 44/126 (34%), Positives = 69/126 (54%), Gaps = 6/126 (4%) Query: 157 ERRGRIYIQA--HIDREVLIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKT 214 E GRI + L V + A+ L D +G SDP+VK+ L+PD K K +TK Sbjct: 10 ENLGRIQFSVGYNFQESTLTVKIMKAQELPAKDFSGTSDPFVKIYLLPDKK--HKLETKV 67 Query: 215 IKCSLNPEWNETFRFQLKESDK--DRRLSVEIWDWDLTSRNDFMGSLSFGISELQKAGVD 272 + +LNP WNETF F+ +K R L +++ D+D SRND +G +S ++++ + Sbjct: 68 KRKNLNPHWNETFLFEGFPYEKVVQRILYLQVLDYDRFSRNDPIGEVSIPLNKVDLTQMQ 127 Query: 273 GWFKLL 278 ++K L Sbjct: 128 TFWKDL 133 >5KMM-A nrPDB Length = 329 Score = 64.3 bits (155), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 68/272 (25%), Positives = 115/272 (42%), Gaps = 30/272 (11%) Query: 337 MKLTDFNFLMVLGKGSFGKVMLSE-----RKGTDELYAVKILKKDVVIQDDDVECTMVEK 391 +K D LG+G+FGKV L+E + L AVK LK+ D + E Sbjct: 32 IKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQ---REA 88 Query: 392 RVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHA-------- 443 +L + + C + L V EY+ GDL ++ G + A Sbjct: 89 ELLTMLQHQHIVRFFGVCTEGRP-LLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPG 147 Query: 444 -------VFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKE---NIW 493 + A+++A G+ +L ++RDL N ++ +KI DFGM ++ + Sbjct: 148 PLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDY 207 Query: 494 DGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQS 552 V +T ++ PE I Y+ + D W+FGV+L+E+ G+ P+ E Sbjct: 208 YRVGGRTMLPI-RWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDC 266 Query: 553 IME-HNVAYPKSMSKEAVAICKGLMTKHPGKR 583 I + + P++ E AI +G + P +R Sbjct: 267 ITQGRELERPRACPPEVYAIMRGCWQREPQQR 298 >4AGU-A nrPDB Length = 311 Score = 64.3 bits (155), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 73/303 (24%), Positives = 126/303 (41%), Gaps = 44/303 (14%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG-KPPFLTQL 406 +G+GS+G V + T ++ A+K K + +DD V + + + L K P L L Sbjct: 11 IGEGSYGVVFKCRNRDTGQIVAIK---KFLESEDDPVIKKIALREIRMLKQLKHPNLVNL 67 Query: 407 HSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAV-FYAAEIAIGLFFLQSKGIIYR 465 F+ RL+ V EY + +++ + + R H V + + F I+R Sbjct: 68 LEVFRRKRRLHLVFEYCDHT-VLHELDRYQRGVPEHLVKSITWQTLQAVNFCHKHNCIHR 126 Query: 466 DLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPE-IIAYQPYGKSVDW 524 D+K +N+++ IK+ DFG + T Y +PE ++ YG VD Sbjct: 127 DVKPENILITKHSVIKLCDFGFARLLTGPSDYYDDEVATRWYRSPELLVGDTQYGPPVDV 186 Query: 525 WAFGVLLYEMLAGQAPFEGE-DEDELF-------------QSIMEHNVAY-------PKS 563 WA G + E+L+G + G+ D D+L+ Q + N + P+ Sbjct: 187 WAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFSGVKIPDPED 246 Query: 564 M----------SKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYI-DWEKLERKE 612 M S A+ + KG + P +RL C + H +F I + E L ++ Sbjct: 247 MEPLELKFPNISYPALGLLKGCLHMDPTERLTC-----EQLLHHPYFENIREIEDLAKEH 301 Query: 613 IQP 615 +P Sbjct: 302 DKP 304 >6DBN-A nrPDB Length = 316 Score = 64.3 bits (155), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 57/198 (28%), Positives = 94/198 (47%), Gaps = 11/198 (5%) Query: 348 LGKGSFGKVMLS----ERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFL 403 LG+G FGKV L E T E AVK LK + + + E +L + Sbjct: 43 LGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPES--GGNHIADLKKEIEILRNLYHENIV 100 Query: 404 TQLHSCFQTM-DRLYFVMEYVNGGDLMYHI-QQVGRFKEPHAVFYAAEIAIGLFFLQSKG 461 C + + + +ME++ G L ++ + + + YA +I G+ +L S+ Sbjct: 101 KYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQ 160 Query: 462 IIYRDLKLDNVMLDSEGHIKIADFGMCK--ENIWDGVTTKTFCGTPDY-IAPEIIAYQPY 518 ++RDL NV+++SE +KI DFG+ K E + T K +P + APE + + Sbjct: 161 YVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKF 220 Query: 519 GKSVDWWAFGVLLYEMLA 536 + D W+FGV L+E+L Sbjct: 221 YIASDVWSFGVTLHELLT 238 >3M42-A nrPDB Length = 299 Score = 63.9 bits (154), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 58/200 (29%), Positives = 86/200 (43%), Gaps = 31/200 (15%) Query: 347 VLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQL 406 VLG G GKV+ K T E +A+K+L+ D +VE + R P + Sbjct: 25 VLGLGINGKVLQIFNKRTQEKFALKMLQ-DCPKARREVE---LHWRASQCPHIVRIVDVY 80 Query: 407 HSCFQTMDRLYFVMEYVNGGDLMYHIQQVG--RFKEPHAVFYAAEIAIGLFFLQSKGIIY 464 + + L VME ++GG+L IQ G F E A I + +L S I + Sbjct: 81 ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAH 140 Query: 465 RDLKLDNVMLDSE---GHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKS 521 RD+K +N++ S+ +K+ DFG KE + Y KS Sbjct: 141 RDVKPENLLYTSKRPNAILKLTDFGFAKET----------------------TGEKYDKS 178 Query: 522 VDWWAFGVLLYEMLAGQAPF 541 D W+ GV++Y +L G PF Sbjct: 179 CDMWSLGVIMYILLCGYPPF 198 >3FI2-A nrPDB Length = 353 Score = 63.9 bits (154), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 42/143 (29%), Positives = 75/143 (52%), Gaps = 8/143 (5%) Query: 416 LYFVMEYVNGGDLMYHIQQVGRFKEPH--AVFYAAEIAIGLFFLQSKGIIYRDLKLDNVM 473 +Y VME ++ ++ QV + + H + ++ G+ L S GII+RDLK N++ Sbjct: 104 VYLVMELMDA-----NLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIV 158 Query: 474 LDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYE 533 + S+ +KI DFG+ + + T + T Y APE+I Y ++VD W+ G ++ E Sbjct: 159 VKSDCTLKILDFGLARTAGTSFMMT-PYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGE 217 Query: 534 MLAGQAPFEGEDEDELFQSIMEH 556 M+ + F G D + + ++E Sbjct: 218 MVRHKILFPGRDYIDQWNKVIEQ 240 >4IAN-A nrPDB Length = 358 Score = 63.9 bits (154), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 58/241 (24%), Positives = 108/241 (44%), Gaps = 23/241 (9%) Query: 342 FNFLMVLGKGSFGKVMLSERKG-TDELYAVKILKKDVVIQDDDV-ECTMVEKRVLALPGK 399 +N G+G F V+ + ++ AVKI++ + ++Q + E ++K A P Sbjct: 32 YNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTGLKELEFLKKLNDADPDD 91 Query: 400 PPFLTQLHSCFQTMDRLYFVMEYVN----------GGDLMYHIQQVGRFKEPHAVFYAAE 449 +L F L V E ++ G D+ HI+ V Y+ + Sbjct: 92 KFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVGLHIKAVRS--------YSQQ 143 Query: 450 IAIGLFFLQSKGIIYRDLKLDNVMLD-SEGHIKIADFGMCKENIWDGVTTKTFCGTPDYI 508 + + L L+ I++ D+K DN++++ S+ +K+ DFG + +T + + Y Sbjct: 144 LFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASHVADNDITP--YLVSRFYR 201 Query: 509 APEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEA 568 APEII + Y +D W+ G LYE+ G+ F G+ + + + M+ P M ++ Sbjct: 202 APEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPNKMIRKG 261 Query: 569 V 569 V Sbjct: 262 V 262 >1JNK-A nrPDB Length = 423 Score = 63.9 bits (154), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 42/143 (29%), Positives = 75/143 (52%), Gaps = 8/143 (5%) Query: 416 LYFVMEYVNGGDLMYHIQQVGRFKEPH--AVFYAAEIAIGLFFLQSKGIIYRDLKLDNVM 473 +Y VME ++ ++ QV + + H + ++ G+ L S GII+RDLK N++ Sbjct: 142 VYLVMELMDA-----NLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIV 196 Query: 474 LDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYE 533 + S+ +KI DFG+ + + T + T Y APE+I Y ++VD W+ G ++ E Sbjct: 197 VKSDCTLKILDFGLARTAGTSFMMT-PYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGE 255 Query: 534 MLAGQAPFEGEDEDELFQSIMEH 556 M+ + F G D + + ++E Sbjct: 256 MVRHKILFPGRDYIDQWNKVIEQ 278 >3LZB-A nrPDB Length = 327 Score = 63.9 bits (154), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 59/237 (24%), Positives = 115/237 (48%), Gaps = 19/237 (8%) Query: 337 MKLTDFNFLMVLGKGSFGKVM----LSERKGTDELYAVKILKKDVVIQDDDVECTMVEKR 392 +K T+F + VLG G+FG V + E + A+K L++ + + + + E Sbjct: 12 LKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKAN--KEILDEAY 69 Query: 393 VLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQ-VGRFKEPHAVFYAAEIA 451 V+A P L C + +L + + + G L+ ++++ + + + +IA Sbjct: 70 VMASVDNPHVCRLLGICLTSTVQL--ITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIA 127 Query: 452 IGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCG----TP-D 506 G+ +L+ + +++RDL NV++ + H+KI DFG+ K G K + P Sbjct: 128 KGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAK---LLGAEEKEYHAEGGKVPIK 184 Query: 507 YIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIMEHNVAYPK 562 ++A E I ++ Y D W++GV ++E++ G P++G E+ SI+E P+ Sbjct: 185 WMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEI-SSILEKGERLPQ 240 >3UIM-A nrPDB Length = 326 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 59/210 (28%), Positives = 98/210 (46%), Gaps = 12/210 (5%) Query: 341 DFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKP 400 +F+ +LG+G FGKV R L AVK LK++ Q +++ E ++++ Sbjct: 31 NFSNKNILGRGGFGKVY-KGRLADGTLVAVKRLKEERT-QGGELQFQ-TEVEMISMAVHR 87 Query: 401 PFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIG----LFF 456 L C +RL V Y+ G + +++ + P IA+G L + Sbjct: 88 NLLRLRGFCMTPTERL-LVYPYMANGSVASCLRERPESQPPLDWPKRQRIALGSARGLAY 146 Query: 457 LQSK---GIIYRDLKLDNVMLDSEGHIKIADFGMCK-ENIWDGVTTKTFCGTPDYIAPEI 512 L II+RD+K N++LD E + DFG+ K + D T GT +IAPE Sbjct: 147 LHDHCDPKIIHRDVKAANILLDEEFEAVVGDFGLAKLMDYKDTHVTTAVRGTIGHIAPEY 206 Query: 513 IAYQPYGKSVDWWAFGVLLYEMLAGQAPFE 542 ++ + D + +GV+L E++ GQ F+ Sbjct: 207 LSTGKSSEKTDVFGYGVMLLELITGQRAFD 236 >4E7W-A nrPDB Length = 394 Score = 63.5 bits (153), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 64/251 (25%), Positives = 114/251 (45%), Gaps = 26/251 (10%) Query: 317 PEEKTANTISKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKD 376 P + I ++G + + V+G GSFG V ++ +DE+ A+K + +D Sbjct: 17 PLDDPNKVIKVLASDGKTGEQREIAYTNCKVIGNGSFGVVFQAKLVESDEV-AIKKVLQD 75 Query: 377 VVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTM-DR-----LYFVMEYVNGGDLMY 430 ++ +++ + K P + L + F + D+ L V+EYV + +Y Sbjct: 76 KRFKNRELQIMRIVKH--------PNVVDLKAFFYSNGDKKDEVFLNLVLEYV--PETVY 125 Query: 431 HI-QQVGRFKEPHAVF----YAAEIAIGLFFLQSKGIIYRDLKLDNVMLDS-EGHIKIAD 484 + + K+ + Y ++ L ++ S GI +RD+K N++LD G +K+ D Sbjct: 126 RASRHYAKLKQTMPMLLIKLYMYQLLRSLAYIHSIGICHRDIKPQNLLLDPPSGVLKLID 185 Query: 485 FGMCKENIWDGVTTKTFCGTPDYIAPEII-AYQPYGKSVDWWAFGVLLYEMLAGQAPFEG 543 FG K I C Y APE+I Y ++D W+ G ++ E++ GQ F G Sbjct: 186 FGSAKILIAGEPNVSYICSR-YYRAPELIFGATNYTTNIDIWSTGCVMAELMQGQPLFPG 244 Query: 544 EDE-DELFQSI 553 E D+L + I Sbjct: 245 ESGIDQLVEII 255 >5VD3-A nrPDB Length = 311 Score = 63.5 bits (153), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 58/216 (26%), Positives = 91/216 (42%), Gaps = 6/216 (2%) Query: 341 DFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKP 400 F L LG GS+G+V K LYAVK D + E G+ Sbjct: 58 SFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRAR-KLAEVGSHEKVGQH 116 Query: 401 PFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVG-RFKEPHAVFYAAEIAIGLFFLQS 459 P +L ++ LY E + G L H + G E Y + + L L S Sbjct: 117 PCCVRLEQAWEEGGILYLQTE-LCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHS 175 Query: 460 KGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYG 519 +G+++ D+K N+ L G K+ DFG+ E + + G P Y+APE++ YG Sbjct: 176 QGLVHLDVKPANIFLGPRGRCKLGDFGLLVE-LGTAGAGEVQEGDPRYMAPELLQGS-YG 233 Query: 520 KSVDWWAFGVLLYEMLAG-QAPFEGEDEDELFQSIM 554 + D ++ G+ + E+ + P GE +L Q + Sbjct: 234 TAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYL 269 >6ANK-A nrPDB Length = 289 Score = 63.2 bits (152), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 45/126 (35%), Positives = 69/126 (54%), Gaps = 6/126 (4%) Query: 157 ERRGRIYIQA--HIDREVLIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKT 214 E GRI + L V V A+ L D +G SDP+VK+ L+PD K K +TK Sbjct: 20 ENLGRIQFSVGYNFQESTLTVKVMKAQELPAKDFSGTSDPFVKIYLLPDKK--HKLETKV 77 Query: 215 IKCSLNPEWNETFRFQLKESDK--DRRLSVEIWDWDLTSRNDFMGSLSFGISELQKAGVD 272 + +LNP WNETF F+ +K R L +++ D+D SRND +G +S ++++ + Sbjct: 78 KRKNLNPHWNETFLFEGFPYEKVVQRILYLQVLDYDRFSRNDPIGEVSIPLNKVDLTQMQ 137 Query: 273 GWFKLL 278 ++K L Sbjct: 138 TFWKDL 143 Score = 50.8 bits (120), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 36/88 (40%), Positives = 53/88 (60%), Gaps = 1/88 (1%) Query: 173 LIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQL- 231 +IV + A+NL MD G SDPYVK+ L+ K K+KT T K +LNP +NE+F F + Sbjct: 169 IIVNIIKARNLKAMDIGGTSDPYVKVWLMYKDKRVEKKKTVTKKRNLNPIFNESFAFDIP 228 Query: 232 KESDKDRRLSVEIWDWDLTSRNDFMGSL 259 E ++ + + + D D SRND +G + Sbjct: 229 TEKLRETTIIITVMDKDKLSRNDVIGKI 256 >4XLV-A nrPDB Length = 328 Score = 62.4 bits (150), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 42/150 (28%), Positives = 77/150 (51%), Gaps = 13/150 (8%) Query: 419 VMEYVNGGDLMYHIQQVGRFKEPH----------AVFYAAEIAIGLFFLQSKGIIYRDLK 468 VME + GDL +++ + E + + AAEIA G+ +L +K ++RDL Sbjct: 120 VMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLA 179 Query: 469 LDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGT--PDYIAPEIIAYQPYGKSVDWWA 526 N M+ + +KI DFGM ++ K G ++APE + + S D W+ Sbjct: 180 ARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWS 239 Query: 527 FGVLLYEMLA-GQAPFEGEDEDELFQSIME 555 FGV+L+E+ + + P++G +++ + +M+ Sbjct: 240 FGVVLWEITSLAEQPYQGLSNEQVLKFVMD 269 >6NT9-A nrPDB Length = 742 Score = 62.4 bits (150), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 51/217 (23%), Positives = 92/217 (42%), Gaps = 31/217 (14%) Query: 347 VLGKGSFGKVMLSERKGTDELYAVKILKK-------DVVIQDDDVECTMVEKRVLALPGK 399 +LG+G+ V K T +L+A+K+ DV +++ +V + K ++ L Sbjct: 14 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAI 73 Query: 400 PPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR---FKEPHAVFYAAEIAIGLFF 456 T H +ME+ G L +++ E + ++ G+ Sbjct: 74 EEETTTRHKVL--------IMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 125 Query: 457 LQSKGIIYRDLKLDNVML----DSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEI 512 L+ GI++R++K N+M D + K+ DFG +E + D + GT +Y+ P++ Sbjct: 126 LRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARE-LEDDEQFVSLYGTEEYLHPDM 184 Query: 513 IA--------YQPYGKSVDWWAFGVLLYEMLAGQAPF 541 + YG +VD W+ GV Y G PF Sbjct: 185 YERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 >3PG1-A nrPDB Length = 362 Score = 62.4 bits (150), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 41/134 (30%), Positives = 64/134 (47%), Gaps = 4/134 (2%) Query: 412 TMDRLYFVMEYVNGGDLMYHIQQVGRFKEP-HAVFYAAEIAIGLFFLQSKGIIYRDLKLD 470 M +LY V E + DL I P H ++ I +GL L G+++RDL Sbjct: 105 AMHKLYLVTELMRT-DLAQVIHDQRIVISPQHIQYFMYHILLGLHVLHEAGVVHRDLHPG 163 Query: 471 NVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA-YQPYGKSVDWWAFGV 529 N++L I I DF + +E+ D T + Y APE++ ++ + K VD W+ G Sbjct: 164 NILLADNNDITICDFNLAREDTADANKTH-YVTHRWYRAPELVMQFKGFTKLVDMWSAGC 222 Query: 530 LLYEMLAGQAPFEG 543 ++ EM +A F G Sbjct: 223 VMAEMFNRKALFRG 236 >4P5Q-A nrPDB Length = 361 Score = 62.4 bits (150), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 51/232 (21%), Positives = 106/232 (45%), Gaps = 21/232 (9%) Query: 337 MKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLAL 396 + T+ + V+G G FG+V K KK++ + ++ EK+ Sbjct: 30 LDATNISIDKVVGAGEFGEVCSGRLKLPS--------KKEISVAIKTLKVGYTEKQRRDF 81 Query: 397 PGKP--------PFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQV-GRFKEPHAVFYA 447 G+ P + +L + V EY+ G L +++ +F V Sbjct: 82 LGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGML 141 Query: 448 AEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCK---ENIWDGVTTKTFCGT 504 IA G+ +L G ++RDL N++++S K++DFG+ + ++ TT+ Sbjct: 142 RGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIP 201 Query: 505 PDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIME 555 + +PE IAY+ + + D W++G++L+E+++ G+ P+ ++ +++ E Sbjct: 202 IRWTSPEAIAYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDE 253 >4EUU-A nrPDB Length = 319 Score = 62.4 bits (150), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 52/217 (23%), Positives = 94/217 (43%), Gaps = 31/217 (14%) Query: 347 VLGKGSFGKVMLSERKGTDELYAVKILKK-------DVVIQDDDVECTMVEKRVLALPGK 399 +LG+G+ V K T +L+A+K+ DV +++ +V + K ++ L Sbjct: 16 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAI 75 Query: 400 PPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQ-VGRFKEPHAVFYAA--EIAIGLFF 456 T H +ME+ G L +++ + P + F ++ G+ Sbjct: 76 EEETTTRHKVL--------IMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 127 Query: 457 LQSKGIIYRDLKLDNVML----DSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEI 512 L+ GI++R++K N+M D + K+ DFG +E + D + GT +Y+ P++ Sbjct: 128 LRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARE-LEDDEQFVSLYGTEEYLHPDM 186 Query: 513 IA--------YQPYGKSVDWWAFGVLLYEMLAGQAPF 541 + YG +VD W+ GV Y G PF Sbjct: 187 YERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 223 >4EUT-A nrPDB Length = 396 Score = 62.0 bits (149), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 51/217 (23%), Positives = 92/217 (42%), Gaps = 31/217 (14%) Query: 347 VLGKGSFGKVMLSERKGTDELYAVKILKK-------DVVIQDDDVECTMVEKRVLALPGK 399 +LG+G+ V K T +L+A+K+ DV +++ +V + K ++ L Sbjct: 16 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAI 75 Query: 400 PPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR---FKEPHAVFYAAEIAIGLFF 456 T H +ME+ G L +++ E + ++ G+ Sbjct: 76 EEETTTRHKVL--------IMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 127 Query: 457 LQSKGIIYRDLKLDNVML----DSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEI 512 L+ GI++R++K N+M D + K+ DFG +E + D + GT +Y+ P++ Sbjct: 128 LRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARE-LEDDEQFVSLYGTEEYLHPDM 186 Query: 513 IA--------YQPYGKSVDWWAFGVLLYEMLAGQAPF 541 + YG +VD W+ GV Y G PF Sbjct: 187 YERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 223 >4E20-A nrPDB Length = 290 Score = 62.0 bits (149), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 60/211 (28%), Positives = 97/211 (45%), Gaps = 39/211 (18%) Query: 348 LGKGSFGKVML----SERKGTDELYAVKILKKDVVIQ-------DDDVECTMVEKRVLAL 396 LG+G FGKV L GT E+ AVK LK+ Q + ++ T+ + ++ Sbjct: 16 LGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSGWQREIEILRTLYHEHIVKY 75 Query: 397 PGKPPFLTQLHSCF-QTMDRLYFVMEYVNGGDLMYHIQQ--VGRFKEPHAVFYAAEIAIG 453 G C Q + VMEYV G L ++ + VG + + +A +I G Sbjct: 76 KG---------CCEDQGEKSVQLVMEYVPLGSLRDYLPRHCVGLAQ---LLLFAQQICEG 123 Query: 454 LFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKE--------NIWDGVTTKTFCGTP 505 + +L ++ I+R L NV+LD++ +KI DFG+ K + + + F Sbjct: 124 MAYLHAQHYIHRALAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVF---- 179 Query: 506 DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA 536 + APE + + + D W+FGV LYE+L Sbjct: 180 -WYAPECLKECKFYYASDVWSFGVTLYELLT 209 >2R2P-A nrPDB Length = 295 Score = 62.0 bits (149), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 53/217 (24%), Positives = 104/217 (47%), Gaps = 11/217 (5%) Query: 347 VLGKGSFGKVMLSERK--GTDEL-YAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFL 403 V+G G FG+V K G EL A+K LK V + + E ++ P + Sbjct: 29 VIGAGEFGEVCSGRLKLPGKRELPVAIKTLK--VGYTEKQRRDFLGEASIMGQFDHPNII 86 Query: 404 TQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQV-GRFKEPHAVFYAAEIAIGLFFLQSKGI 462 L + V EY+ G L +++ G+F V I+ G+ +L G Sbjct: 87 -HLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGISAGMKYLSDMGY 145 Query: 463 IYRDLKLDNVMLDSEGHIKIADFGMCK---ENIWDGVTTKTFCGTPDYIAPEIIAYQPYG 519 ++RDL N++++S K++DFG+ + ++ TT+ + APE IA++ + Sbjct: 146 VHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAFRKFT 205 Query: 520 KSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIME 555 + D W++G++++E+++ G+ P+ ++ +++ E Sbjct: 206 SASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEE 242 >5AR8-A nrPDB Length = 326 Score = 62.0 bits (149), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 59/220 (26%), Positives = 102/220 (46%), Gaps = 21/220 (9%) Query: 338 KLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALP 397 KL D +L +G+ G V + AVK L + D + + + E +L Sbjct: 33 KLADLRYL---SRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKA 89 Query: 398 GKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKE---PHAVFYAAEIAIGL 454 L L C + + L V EY+ G L + + + + P EIA+G+ Sbjct: 90 RFSYILPILGICNEP-EFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGV 148 Query: 455 FFLQ--SKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPD-----Y 507 +L + +++ DLK N++LD+E H+KIADFG+ K + +++ P+ Y Sbjct: 149 NYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIY 208 Query: 508 IAPEIIAYQPYGKSV-----DWWAFGVLLYEMLAGQAPFE 542 + PE Y+P KS D +++ V+ +E+L+ + PFE Sbjct: 209 MPPE--NYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFE 246 >1JPA-A nrPDB Length = 312 Score = 62.0 bits (149), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 54/228 (23%), Positives = 104/228 (45%), Gaps = 14/228 (6%) Query: 347 VLGKGSFGKVMLSERK--GTDELY-AVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFL 403 V+G G FG+V K G E++ A+K LK + + E ++ P + Sbjct: 40 VIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYT--EKQRRDFLSEASIMGQFDHPNVI 97 Query: 404 TQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQV-GRFKEPHAVFYAAEIAIGLFFLQSKGI 462 L + + E++ G L ++Q G+F V IA G+ +L Sbjct: 98 -HLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLADMNY 156 Query: 463 IYRDLKLDNVMLDSEGHIKIADFGMCK---ENIWDGVTTKTFCGT--PDYIAPEIIAYQP 517 ++RDL N++++S K++DFG+ + ++ D T G + APE I Y+ Sbjct: 157 VHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRK 216 Query: 518 YGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIMEHNVAYPKSM 564 + + D W++G++++E+++ G+ P+ ++ +I E + P M Sbjct: 217 FTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAI-EQDYRLPPPM 263 >1UOW-A nrPDB Length = 159 Score = 62.0 bits (149), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 38/91 (41%), Positives = 57/91 (62%), Gaps = 1/91 (1%) Query: 173 LIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLK 232 L VV+ +AKNL MD GLSDPYVK+ L+ + K K+KT K +LNP +NE+F F++ Sbjct: 27 LTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKNTLNPYYNESFSFEVP 86 Query: 233 -ESDKDRRLSVEIWDWDLTSRNDFMGSLSFG 262 E + ++ V + D+D +ND +G + G Sbjct: 87 FEQIQKVQVVVTVLDYDKIGKNDAIGKVFVG 117 >2VWV-A nrPDB Length = 302 Score = 61.6 bits (148), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 54/237 (22%), Positives = 108/237 (45%), Gaps = 16/237 (6%) Query: 330 NNGNRDRMKLTDFNFLM---VLGKGSFGKVMLSERKG---TDELYAVKILKKDVVIQDDD 383 N R+ K D +++ V+G G FG+V K + A+K LK + Sbjct: 3 NEAVREFAKEIDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYT--ERQ 60 Query: 384 VECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQ-QVGRFKEPH 442 + E ++ + P + +L + + E++ G L ++ G+F Sbjct: 61 RREFLSEASIMG-QFEHPNIIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVIQ 119 Query: 443 AVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCK---ENIWDGVTTK 499 V IA G+ +L ++RDL N++++S K++DFG+ + EN D T Sbjct: 120 LVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTETS 179 Query: 500 TFCGT--PDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSI 553 + G + APE IA++ + + D W++G++++E+++ G+ P+ ++ +I Sbjct: 180 SLGGKIPIRWTAPEAIAFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAI 236 >5LPV-A nrPDB Length = 296 Score = 61.6 bits (148), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 38/102 (37%), Positives = 57/102 (55%), Gaps = 9/102 (8%) Query: 451 AIGLFFLQ---SKGIIYRDLKLDNVMLDSEGHIKIADFGMCK--ENIWDGVTTKTFCGTP 505 A GL FL S II+RD+K NV+LD +++DFGM + + ++ T GTP Sbjct: 127 ARGLAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTP 186 Query: 506 DYIAPEIIAYQPYGKSV--DWWAFGVLLYEMLAGQAPFEGED 545 Y+ PE YQ + S D +++GV+L E+L G+ P + D Sbjct: 187 GYVPPEY--YQSFRCSTKGDVYSYGVVLLELLTGKRPTDSPD 226 >5LPZ-A nrPDB Length = 332 Score = 61.6 bits (148), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 38/102 (37%), Positives = 57/102 (55%), Gaps = 9/102 (8%) Query: 451 AIGLFFLQ---SKGIIYRDLKLDNVMLDSEGHIKIADFGMCK--ENIWDGVTTKTFCGTP 505 A GL FL S II+RD+K NV+LD +++DFGM + + ++ T GTP Sbjct: 127 ARGLAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTP 186 Query: 506 DYIAPEIIAYQPYGKSV--DWWAFGVLLYEMLAGQAPFEGED 545 Y+ PE YQ + S D +++GV+L E+L G+ P + D Sbjct: 187 GYVPPEY--YQSFRCSTKGDVYSYGVVLLELLTGKRPTDSPD 226 >4M7I-A nrPDB Length = 299 Score = 61.6 bits (148), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 72/297 (24%), Positives = 131/297 (44%), Gaps = 42/297 (14%) Query: 339 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 398 LTDF + LG+G FG V ++ K D YA+K ++ + ++ E M E + LA Sbjct: 4 LTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIR--LPNRELAREKVMREVKALAKLE 61 Query: 399 KPPFLTQLHSCFQ--TMDRL---------YFVMEYV---NGGDLMYHIQQVGRFKEPHAV 444 P + ++ + T ++L Y M+ N D M + + + Sbjct: 62 HPGIVRYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCL 121 Query: 445 FYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTF--- 501 +IA + FL SKG+++RDLK N+ + +K+ DFG+ D Sbjct: 122 HIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPM 181 Query: 502 ---------CGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQS 552 GT Y++PE I Y VD ++ G++L+E+L PF + E ++ Sbjct: 182 PAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELL---YPFSTQMER--VRT 236 Query: 553 IME-HNVAYPKSMSKE---AVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDW 605 + + N+ +P +++ + + +++ P +R PE +I E+A F +D+ Sbjct: 237 LTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMER----PEA-INIIENAVFEDLDF 288 >3ZBF-A nrPDB Length = 322 Score = 61.2 bits (147), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 64/246 (26%), Positives = 109/246 (44%), Gaps = 41/246 (16%) Query: 336 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDEL--------YAVKILKKDVVIQDDDVECT 387 R KLT ++LG G+FG+V E D L AVK LKK Q+ +E Sbjct: 32 REKLT---LRLLLGSGAFGEVY--EGTAVDILGVGSGEIKVAVKTLKKGSTDQEK-IEF- 84 Query: 388 MVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYA 447 + E +++ P L QL C + Y ++E + GGDL+ +++ K A FY Sbjct: 85 LKEAHLMSKFNHPNILKQLGVCLLNEPQ-YIILELMEGGDLLTYLR-----KARMATFYG 138 Query: 448 ------------AEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGH-----IKIADFGMCKE 490 +I+ G +L+ I+RDL N ++ + + +KI DFG+ ++ Sbjct: 139 PLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARD 198 Query: 491 NIWDGVTTKTFCGT--PDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDED 547 + K G ++APE + + D W+FG+L++E+L G P+ Sbjct: 199 IYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNL 258 Query: 548 ELFQSI 553 ++ + Sbjct: 259 DVLNYV 264 >4L9M-A nrPDB Length = 559 Score = 61.2 bits (147), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 23/59 (38%), Positives = 33/59 (55%) Query: 37 HKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPAS 95 H F + +PTFC +C F+WG KQG++C+ C HK+C + V F C K P + Sbjct: 494 HNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKDLVVFECKKRAKNPVA 552 Score = 56.6 bits (135), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 22/42 (52%), Positives = 28/42 (66%) Query: 102 HKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRC 143 H F+ TY PTFCD+C L+G+I QG +C C MN HK+C Sbjct: 494 HNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQC 535 >6O8B-A nrPDB Length = 665 Score = 61.2 bits (147), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 51/217 (23%), Positives = 91/217 (41%), Gaps = 31/217 (14%) Query: 347 VLGKGSFGKVMLSERKGTDELYAVKILKK-------DVVIQDDDVECTMVEKRVLALPGK 399 +LG+G+ V K T +L+A+K+ DV +++ +V + K ++ L Sbjct: 22 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAI 81 Query: 400 PPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR---FKEPHAVFYAAEIAIGLFF 456 T H +ME+ G L +++ E + ++ G+ Sbjct: 82 EEETTTRHKVL--------IMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 133 Query: 457 LQSKGIIYRDLKLDNVML----DSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEI 512 L+ GI++R++K N+M D + K+ DFG +E + D GT +Y+ P++ Sbjct: 134 LRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARE-LEDDEQFVELYGTEEYLHPDM 192 Query: 513 IA--------YQPYGKSVDWWAFGVLLYEMLAGQAPF 541 + YG +VD W+ GV Y G PF Sbjct: 193 YERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 229 >2F9G-A nrPDB Length = 353 Score = 61.2 bits (147), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 52/223 (23%), Positives = 101/223 (45%), Gaps = 23/223 (10%) Query: 340 TDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK 399 +DF +LG+G++G V + K T E+ A+K K + + T+ E ++L Sbjct: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIK--KIEPFDKPLFALRTLREIKILKHFKH 68 Query: 400 PPFLT----QLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 455 +T Q F+ + +Y + E + ++ + + H ++ + + Sbjct: 69 ENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVK 126 Query: 456 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCK---ENIWD---------GVTTKTFCG 503 L +I+RDLK N++++S +K+ DFG+ + E+ D G+T + Sbjct: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMT--EYVA 184 Query: 504 TPDYIAPEI-IAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGED 545 T Y APE+ + Y +++D W+ G +L E+ + F G D Sbjct: 185 TRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRD 227 >5W5C-F nrPDB Length = 282 Score = 60.8 bits (146), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 38/91 (41%), Positives = 57/91 (62%), Gaps = 1/91 (1%) Query: 173 LIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLK 232 L VV+ +AKNL MD GLSDPYVK+ L+ + K K+KT K +LNP +NE+F F++ Sbjct: 150 LTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKNTLNPYYNESFSFEVP 209 Query: 233 -ESDKDRRLSVEIWDWDLTSRNDFMGSLSFG 262 E + ++ V + D+D +ND +G + G Sbjct: 210 FEQIQKVQVVVTVLDYDKIGKNDAIGKVFVG 240 Score = 57.0 bits (136), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 39/114 (34%), Positives = 64/114 (56%), Gaps = 4/114 (3%) Query: 173 LIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLK 232 L+V + A L +D G SDPYVK+ L+PD K K +TK + +LNP +NE F F++ Sbjct: 19 LLVGIIQAAELPALDMGGTSDPYVKVFLLPDKK--KKFETKVHRKTLNPVFNEQFTFKVP 76 Query: 233 ESD-KDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKAGV-DGWFKLLSQEEGE 284 S+ + L + ++D+D S++D +G ++ + V + W L S E+ E Sbjct: 77 YSELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNTVDFGHVTEEWRDLQSAEKEE 130 >2W96-B nrPDB Length = 306 Score = 60.8 bits (146), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 33/103 (32%), Positives = 53/103 (51%), Gaps = 1/103 (0%) Query: 453 GLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEI 512 GL FL + I++RDLK +N+++ S G +K+ADFG+ + + + T Y APE+ Sbjct: 124 GLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQ-MALDPVVVTLWYRAPEV 182 Query: 513 IAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIME 555 + Y VD W+ G + EM + F G E + I + Sbjct: 183 LLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFD 225 >5MJB-A nrPDB Length = 305 Score = 60.8 bits (146), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 59/248 (23%), Positives = 113/248 (45%), Gaps = 17/248 (6%) Query: 330 NNGNRDRMKLTDFNFLM---VLGKGSFGKVMLSERK--GTDELY-AVKILKKDVVIQDDD 383 N R+ K D +F+ V+G G FG+V K G E+Y A+K LK + Sbjct: 13 NEAVREFAKEIDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGY--SEKQ 70 Query: 384 VECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQV-GRFKEPH 442 + E ++ + +L + + E++ L ++Q G+F Sbjct: 71 RRDFLSEASIMGQFDHRNII-RLEGVVTKSRPVMIITEFMENCALDSFLRQNDGQFTVIQ 129 Query: 443 AVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCK---ENIWDGVTTK 499 V IA G+ +L ++RDL N++++S K++DFG+ + ++ D T Sbjct: 130 LVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTS 189 Query: 500 TFCGT--PDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIMEH 556 + G + APE IAY+ + + D W++G++++E+++ G+ P+ ++ +I E Sbjct: 190 SLGGKIPVRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAI-EQ 248 Query: 557 NVAYPKSM 564 + P M Sbjct: 249 DYRLPPPM 256 >2BUJ-A nrPDB Length = 317 Score = 60.8 bits (146), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 66/269 (24%), Positives = 112/269 (41%), Gaps = 35/269 (13%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 + F+ LG+G F V L E YA LK+ + + D E E + L P Sbjct: 31 YLFIQKLGEGGFSYVDLVEGLHDGHFYA---LKRILCHEQQDREEAQREADMHRLFNHPN 87 Query: 402 FLTQLHSCFQ---TMDRLYFVMEYVNGGDLMYHIQQV---GRF-KEPHAVFYAAEIAIGL 454 L + C + + ++ + G L I+++ G F E ++ I GL Sbjct: 88 ILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFLTEDQILWLLLGICRGL 147 Query: 455 FFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCK------ENIWDGVTTKTFCG---TP 505 + +KG +RDLK N++L EG + D G E +T + + T Sbjct: 148 EAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSRQALTLQDWAAQRCTI 207 Query: 506 DYIAPEIIAYQPY---GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQS------IMEH 556 Y APE+ + Q + + D W+ G +LY M+ G+ P+ D +FQ +++ Sbjct: 208 SYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPY-----DMVFQKGDSVALAVQN 262 Query: 557 NVAYPKS--MSKEAVAICKGLMTKHPGKR 583 ++ P+S S + +MT P +R Sbjct: 263 QLSIPQSPRHSSALWQLLNSMMTVDPHQR 291 >5FM2-A nrPDB Length = 355 Score = 60.5 bits (145), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 64/271 (23%), Positives = 115/271 (42%), Gaps = 38/271 (14%) Query: 347 VLGKGSFGKVM------LSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKP 400 LG+G FGKV+ L R G + AVK+LK++ ++ + E VL P Sbjct: 71 TLGEGEFGKVVKATAFHLKGRAGYTTV-AVKMLKENA--SPSELRDLLSEFNVLKQVNHP 127 Query: 401 PFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHA----------------- 443 + +C Q L ++EY G L +++ + + Sbjct: 128 HVIKLYGACSQD-GPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDER 186 Query: 444 -------VFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGV 496 + +A +I+ G+ +L +++RDL N+++ +KI+DFG+ ++ + Sbjct: 187 ALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDS 246 Query: 497 TTKTFCGT--PDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSI 553 K G ++A E + Y D W+FGVLL+E++ G P+ G + LF + Sbjct: 247 YVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLL 306 Query: 554 ME-HNVAYPKSMSKEAVAICKGLMTKHPGKR 583 H + P + S+E + + P KR Sbjct: 307 KTGHRMERPDNCSEEMYRLMLQCWKQEPDKR 337 >3VN9-A nrPDB Length = 340 Score = 60.1 bits (144), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 69/288 (23%), Positives = 124/288 (43%), Gaps = 34/288 (11%) Query: 332 GNRD-RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDV-------VIQDDD 383 GN++ +K D +M LG+G++G V + ++ AVK ++ V ++ D D Sbjct: 42 GNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLD 101 Query: 384 VECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKE-PH 442 + V+ PF + ++ ME ++ ++ Q + + + P Sbjct: 102 ISMRTVDC---------PFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPE 152 Query: 443 AVF--YAAEIAIGLFFLQSK-GIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTK 499 + A I L L SK +I+RD+K NV++++ G +K+ DFG+ + D V Sbjct: 153 DILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISG-YLVDSVAKT 211 Query: 500 TFCGTPDYIAPEII----AYQPYGKSVDWWAFGVLLYEMLAGQAPFE--GEDEDELFQSI 553 G Y+APE I + Y D W+ G+ + E+ + P++ G +L Q + Sbjct: 212 IDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVV 271 Query: 554 MEHNVAYPK-SMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFF 600 E + P S E V + K+ +R PE + +H FF Sbjct: 272 EEPSPQLPADKFSAEFVDFTSQCLKKNSKER-PTYPE----LMQHPFF 314 >3AOX-A nrPDB Length = 344 Score = 59.7 bits (143), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 56/231 (24%), Positives = 103/231 (44%), Gaps = 21/231 (9%) Query: 341 DFNFLMVLGKGSFGKVMLSERKGTDE-----LYAVKILKKDVVIQDDDVECTMVEKRVLA 395 + + LG G+FG+V + G AVK L +V + D+++ M E +++ Sbjct: 48 NITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLP-EVCSEQDELDFLM-EALIIS 105 Query: 396 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQV-GRFKEPHAV------FYAA 448 + + Q++ R + ++E + GGDL +++ R +P ++ A Sbjct: 106 KFNHQNIVRCIGVSLQSLPR-FILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVAR 164 Query: 449 EIAIGLFFLQSKGIIYRDLKLDNVMLDSEGH---IKIADFGMCKENIWDGVTTKTFCGT- 504 +IA G +L+ I+RD+ N +L G KI DFGM ++ K C Sbjct: 165 DIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAML 224 Query: 505 -PDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSI 553 ++ PE + D W+FGVLL+E+ + G P+ + E+ + + Sbjct: 225 PVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFV 275 >3PLS-A nrPDB Length = 298 Score = 59.7 bits (143), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 53/202 (26%), Positives = 92/202 (45%), Gaps = 10/202 (4%) Query: 347 VLGKGSFGKVMLSER--KGTDELY-AVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFL 403 V+GKG FG V E + + + A+K L + +Q VE + E ++ P L Sbjct: 28 VIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQ--VEAFLREGLLMRGLNHPNVL 85 Query: 404 TQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKE-PHAVFYAAEIAIGLFFLQSKGI 462 + + ++ Y+ GDL+ I+ R + + ++A G+ +L + Sbjct: 86 ALIGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLAEQKF 145 Query: 463 IYRDLKLDNVMLDSEGHIKIADFGMCKENI---WDGVTTKTFCGTP-DYIAPEIIAYQPY 518 ++RDL N MLD +K+ADFG+ ++ + + V P + A E + + Sbjct: 146 VHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWTALESLQTYRF 205 Query: 519 GKSVDWWAFGVLLYEMLAGQAP 540 D W+FGVLL+E+L AP Sbjct: 206 TTKSDVWSFGVLLWELLTRGAP 227 >1W15-A nrPDB Length = 153 Score = 59.7 bits (143), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 38/99 (38%), Positives = 54/99 (54%), Gaps = 1/99 (1%) Query: 173 LIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLK 232 L VVV A++L D +GLSDPYVK+ L K SK+KT KC+ N +NE F F + Sbjct: 32 LTVVVLKARHLPKSDVSGLSDPYVKVNLYHAKKRISKKKTHVKKCTPNAVFNELFVFDIP 91 Query: 233 -ESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKAG 270 ES ++ + + D + SRN+ +G L G + G Sbjct: 92 CESLEEISVEFLVLDSERGSRNEVIGRLVLGATAEGSGG 130 >4C59-A nrPDB Length = 340 Score = 59.7 bits (143), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 51/182 (28%), Positives = 81/182 (44%), Gaps = 30/182 (16%) Query: 444 VFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMC--------------- 488 +FY A+ Q II+RDLK++N++L ++G IK+ DFG Sbjct: 140 IFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQR 199 Query: 489 KENIWDGVTTKTFCGTPDYIAPEIIAYQ---PYGKSVDWWAFGVLLYEMLAGQAPFEGED 545 + + + +T T TP Y PEII P G+ D WA G +LY + Q PFE Sbjct: 200 RALVEEEITRNT---TPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDGA 256 Query: 546 EDELFQ---SIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRY 602 + + SI H+ Y S + + ++ +P +RL E ++E A R Sbjct: 257 KLRIVNGKYSIPPHDTQYTVFHS-----LIRAMLQVNPEERLSIA-EVVHQLQEIAAARN 310 Query: 603 ID 604 ++ Sbjct: 311 VN 312 >5UIU-A nrPDB Length = 323 Score = 59.3 bits (142), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 36/102 (35%), Positives = 54/102 (52%), Gaps = 3/102 (2%) Query: 451 AIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCK--ENIWDGVTTKTFCGTPDYI 508 A G+ FL I+RD+K N++LD KI+DFG+ + E V T GT Y+ Sbjct: 159 ANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYM 218 Query: 509 APEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELF 550 APE + + KS D ++FGV+L E++ G + E +L Sbjct: 219 APEALRGEITPKS-DIYSFGVVLLEIITGLPAVDEHREPQLL 259 >2BWQ-A nrPDB Length = 129 Score = 59.3 bits (142), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 39/127 (30%), Positives = 71/127 (55%), Gaps = 12/127 (9%) Query: 160 GRIYIQAHIDR--EVLIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKC 217 G++ I+ D+ LIV + AK+L + +PYVK+ +PD ++K++TKT+K Sbjct: 5 GQLSIKLWFDKVGHQLIVTILGAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKK 64 Query: 218 SLNPEWNETFRFQ--LKESDKDRRLSVEIWDWDLT--SRNDFMGSLSFGISELQKAGVDG 273 +L P+WN+TF + + ++R L + +WD ++F+G + + EL+ A +D Sbjct: 65 TLEPKWNQTFIYSPVHRREFRERMLEITLWDQARVREEESEFLGEI---LIELETALLDD 121 Query: 274 ---WFKL 277 W+KL Sbjct: 122 EPHWYKL 128 >4M66-A nrPDB Length = 325 Score = 58.9 bits (141), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 56/216 (25%), Positives = 97/216 (44%), Gaps = 20/216 (9%) Query: 333 NRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKR 392 +R+ +K +F +GKG FG V + + + AVKI+ + + + + Sbjct: 18 SREELKKLEF-----VGKGGFGVVFRAHHRTWNHDVAVKIVNSKKISWEVKAMVNLRNEN 72 Query: 393 VLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAI 452 VL L G L Q + V ++ G L +Q P E+ + Sbjct: 73 VLLLLGVTEDLQWDFVSGQAL-----VTRFMENGSLAGLLQPEAPRPWPLLCRLLQEVVL 127 Query: 453 GLFFLQS--KGIIYRDLKLDNVMLDSEGHIKIADFGMCK------ENIWDGVTTKTFCGT 504 G+ +L S +++RDLK N++LD E H K+ADFG+ G ++ GT Sbjct: 128 GMCYLHSLDPPLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQSGSGSGSGSRDSGGT 187 Query: 505 PDYIAPEII--AYQPYGKSVDWWAFGVLLYEMLAGQ 538 Y+ PE++ K+ D ++FG+L++ +LAG+ Sbjct: 188 LAYLDPELLFKVNLKASKASDVYSFGILVWAVLAGR 223 >5H4Y-A nrPDB Length = 150 Score = 58.9 bits (141), Expect = 7e-09, Method: Composition-based stats. Identities = 39/116 (33%), Positives = 65/116 (56%), Gaps = 6/116 (5%) Query: 173 LIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLK 232 L+V + A L +D G SDPYV++ L+PD + + +TK + +LNP + ETF F++ Sbjct: 33 LLVGILQAMGLAALDLGGSSDPYVRVYLLPDKR--RRYETKVHRQTLNPHFGETFAFKVP 90 Query: 233 ESD-KDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKA-GVDGWFKLLS--QEEGE 284 + R L + ++D+D SRND +G + +S + V W +L + +EE E Sbjct: 91 YVELGGRVLVMAVYDFDRFSRNDAIGEVRVPMSSVDLGRPVQAWRELQAAPREEQE 146 >5OAT-A nrPDB Length = 411 Score = 58.5 bits (140), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 43/148 (29%), Positives = 66/148 (44%), Gaps = 16/148 (10%) Query: 453 GLFFLQSKGIIYRDLKLDNVMLDSEGH----IKIADFGMCKENIWDGVTTKTFC------ 502 G+ + + GI +RDLK DN++LD+ + I+DFG C + +G++ Sbjct: 165 GVAHMTAHGIAHRDLKSDNLLLDTSEPESPILVISDFGCCLADKTNGLSLPYTSYEMDKG 224 Query: 503 GTPDYIAPEIIAYQPYGKSV------DWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEH 556 G +APEII +P SV D WA G + YE+ PF G + F Sbjct: 225 GNTALMAPEIICQKPGTFSVLNYSKADLWAVGAIAYEIFNCHNPFYGPSRLKNFNYKEGD 284 Query: 557 NVAYPKSMSKEAVAICKGLMTKHPGKRL 584 P + A+ L+ ++P KRL Sbjct: 285 LPKLPDEVPTVIQALVANLLKRNPNKRL 312 >4O2Z-A nrPDB Length = 377 Score = 58.5 bits (140), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 54/243 (22%), Positives = 107/243 (44%), Gaps = 13/243 (5%) Query: 340 TDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILK---KDV-----VIQDDDVECTMVEK 391 + + L +LG G++G T E ++K + +DV V+++ D+ + Sbjct: 45 SKYTLLKILGMGAYGIACSCLDGDTGEKVSIKKCRDVFRDVEDGKRVLREIDMMRFFHHE 104 Query: 392 RVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIA 451 +L + P L + + F+ + +V+ + D+ ++ +E H ++ +I Sbjct: 105 NLLNVVNILPPLKREYHSFEDV----YVVTPLMDVDMNVVLRSRQVLEESHMQYFVYQIL 160 Query: 452 IGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPE 511 GL +L S + +RDLK N++ + +KI DFG+ + + T Y PE Sbjct: 161 RGLKYLHSANVAHRDLKPANLVTNISCELKIIDFGLSRSVDVPYSELTDYVITRWYRPPE 220 Query: 512 IIAYQP-YGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVA 570 ++ Y +VD W+ G + EM + F G + + + I +H P S+ + A Sbjct: 221 LLLENTNYSTAVDIWSVGCIFAEMYNRKPVFPGRNTMDQLRMIAQHIGKPPASIVEHREA 280 Query: 571 ICK 573 + K Sbjct: 281 LEK 283 >3LLT-A nrPDB Length = 360 Score = 58.5 bits (140), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 65/266 (24%), Positives = 113/266 (42%), Gaps = 47/266 (17%) Query: 339 LTDFNFLMV--LGKGSFGKVMLSERKGTDELYAVKILKK-DVVIQDDDVECTMVEKRVLA 395 L + FL++ +G G+FG+V+L + + YAVK+++ + +E ++ K++ Sbjct: 32 LLNNAFLVIRKMGDGTFGRVLLCQHIDNKKYYAVKVVRNIKKYTRSAKIEADIL-KKIQN 90 Query: 396 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHA---VFYAAEIAI 452 + + H F D + + E + G +Y I + H Y EI Sbjct: 91 DDINNNNIVKYHGKFMYYDHMCLIFEPL--GPSLYEIITRNNYNGFHIEDIKLYCIEILK 148 Query: 453 GLFFLQSKGIIYRDLKLDNVMLD--------------------------SEGHIKIADFG 486 L +L+ + + DLK +N++LD S G IK+ DFG Sbjct: 149 ALNYLRKMSLTHTDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRTKSTG-IKLIDFG 207 Query: 487 MCK-ENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGED 545 ++ + G + T Y APE+I + S D W+FG +L E+ G F + Sbjct: 208 CATFKSDYHG----SIINTRQYRAPEVILNLGWDVSSDMWSFGCVLAELYTGSLLFRTHE 263 Query: 546 EDE---LFQSIMEHNVAYPKSMSKEA 568 E + +SI++ PK+M EA Sbjct: 264 HMEHLAMMESIIQ---PIPKNMLYEA 286 >3ZZW-A nrPDB Length = 289 Score = 58.5 bits (140), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 59/254 (23%), Positives = 108/254 (42%), Gaps = 33/254 (12%) Query: 332 GNRDRMKLTDFNFLMVLGKGSFGKVMLSERKG-----TDELYAVKILKKDV--VIQDDDV 384 G + L+ F+ LG+ FGKV G + A+K LK ++++ Sbjct: 1 GKLKEISLSAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFR 60 Query: 385 ECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHI------QQVGR- 437 M+ R+ + P + L L + Y + GDL + VG Sbjct: 61 HEAMLRARL-----QHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGST 115 Query: 438 ---------FKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMC 488 + P V A+IA G+ +L S ++++DL NV++ + ++KI+D G+ Sbjct: 116 DDDRTVKSALEPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLF 175 Query: 489 KENIWDGVTTKTFCGT---PDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGE 544 +E ++ K + ++APE I Y + D W++GV+L+E+ + G P+ G Sbjct: 176 RE-VYAADYYKLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGY 234 Query: 545 DEDELFQSIMEHNV 558 ++ + I V Sbjct: 235 SNQDVVEMIRNRQV 248 >4TS6-A nrPDB Length = 132 Score = 58.2 bits (139), Expect = 1e-08, Method: Composition-based stats. Identities = 36/122 (29%), Positives = 61/122 (50%), Gaps = 4/122 (3%) Query: 160 GRIYIQAHIDREVL--IVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKC 217 GR+ ++ D+ L IV + A L +PY K+ L+PD +SK++TKT+ Sbjct: 10 GRLQLKLGYDQNTLQLIVTLVCATGLSLRQSGAGRNPYAKVFLLPDRSHKSKRRTKTVGT 69 Query: 218 SLNPEWNETFRFQ-LKESDKD-RRLSVEIWDWDLTSRNDFMGSLSFGISELQKAGVDGWF 275 + P W +TF + L+ D + R L V +WD+ NDF+G + ++ W+ Sbjct: 70 TCEPRWGQTFVYSGLRRCDLNGRLLEVTLWDYVRYGANDFIGEVVIDLAHHILDDEAEWY 129 Query: 276 KL 277 +L Sbjct: 130 QL 131 >2QKW-B nrPDB Length = 321 Score = 58.2 bits (139), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 56/208 (26%), Positives = 92/208 (44%), Gaps = 11/208 (5%) Query: 340 TDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK 399 +F+ ++G G FGKV KG A LK+ +E E L+ Sbjct: 39 NNFDHKFLIGHGVFGKVY----KGVLRDGAKVALKRRTPESSQGIEEFETEIETLSFCRH 94 Query: 400 PPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIG----LF 455 P ++ + C + + + + +Y+ G+L H+ + EI IG L Sbjct: 95 PHLVSLIGFCDER-NEMILIYKYMENGNLKRHLYGSDLPTMSMSWEQRLEICIGAARGLH 153 Query: 456 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENI-WDGVTTKTFC-GTPDYIAPEII 513 +L ++ II+RD+K N++LD KI DFG+ K+ D T GT YI PE Sbjct: 154 YLHTRAIIHRDVKSINILLDENFVPKITDFGISKKGTELDQTHLSTVVKGTLGYIDPEYF 213 Query: 514 AYQPYGKSVDWWAFGVLLYEMLAGQAPF 541 + D ++FGV+L+E+L ++ Sbjct: 214 IKGRLTEKSDVYSFGVVLFEVLCARSAI 241 >5L6P-A nrPDB Length = 298 Score = 57.8 bits (138), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 34/135 (25%), Positives = 70/135 (51%), Gaps = 7/135 (5%) Query: 436 GRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCK---ENI 492 G+F V IA G+ +L ++RDL N++++S K++DFG+ + ++ Sbjct: 116 GQFTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDP 175 Query: 493 WDGVTTKTFCGT--PDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDEL 549 D T + G + APE IAY+ + + D W++G++++E+++ G+ P+ ++ Sbjct: 176 SDPTYTSSLGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDV 235 Query: 550 FQSIMEHNVAYPKSM 564 ++ E + P M Sbjct: 236 INAV-EQDYRLPPPM 249 >3GC0-A nrPDB Length = 329 Score = 57.4 bits (137), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 55/214 (25%), Positives = 99/214 (46%), Gaps = 16/214 (7%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 407 LG+G++G+V + T+E A+K ++ + +++ V T + + L + + +L Sbjct: 42 LGEGTYGEVYKAIDTVTNETVAIKRIRLEH--EEEGVPGTAIREVSLLKELQHRNIIELK 99 Query: 408 SCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDL 467 S RL+ + EY DL ++ + + ++ G+ F S+ ++RDL Sbjct: 100 SVIHHNHRLHLIFEYAEN-DLKKYMDKNPDVSMRVIKSFLYQLINGVNFCHSRRCLHRDL 158 Query: 468 KLDNVMLDSEGH-----IKIADFGMCKENIWDGVTTKTFCG---TPDYIAPEII-AYQPY 518 K N++L +KI DFG+ + G+ + F T Y PEI+ + Y Sbjct: 159 KPQNLLLSVSDASETPVLKIGDFGLARAF---GIPIRQFTHEIITLWYRPPEILLGSRHY 215 Query: 519 GKSVDWWAFGVLLYEMLAGQAPFEGEDE-DELFQ 551 SVD W+ + EML F G+ E D+LF+ Sbjct: 216 STSVDIWSIACIWAEMLMKTPLFPGDSEIDQLFK 249 >6HMD-A nrPDB Length = 365 Score = 57.4 bits (137), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 42/136 (30%), Positives = 68/136 (50%), Gaps = 17/136 (12%) Query: 418 FVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLD-S 476 V EY+N D Q + F FY E+ L + SKGI++RD+K NVM+D Sbjct: 127 LVFEYINNTDFKQLYQILTDFD---IRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQ 183 Query: 477 EGHIKIADFGMCK-----ENIWDGVTTKTFCGTPDYIAPEIIA-YQPYGKSVDWWAFGVL 530 + +++ D+G+ + + V ++ F G PE++ YQ Y S+D W+ G + Sbjct: 184 QKKLRLIDWGLAEFYHPAQEYNVRVASRYFKG------PELLVDYQMYDYSLDMWSLGCM 237 Query: 531 LYEMLAGQAP-FEGED 545 L M+ + P F G+D Sbjct: 238 LASMIFRREPFFHGQD 253 >3I81-A nrPDB Length = 315 Score = 57.0 bits (136), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 39/150 (26%), Positives = 73/150 (48%), Gaps = 13/150 (8%) Query: 419 VMEYVNGGDLMYHIQQVGRFKEPHAVF----------YAAEIAIGLFFLQSKGIIYRDLK 468 +ME + GDL +++ + E + V A EIA G+ +L + ++RDL Sbjct: 99 IMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLA 158 Query: 469 LDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGT--PDYIAPEIIAYQPYGKSVDWWA 526 N M+ + +KI DFGM ++ K G +++PE + + D W+ Sbjct: 159 ARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWS 218 Query: 527 FGVLLYEMLA-GQAPFEGEDEDELFQSIME 555 FGV+L+E+ + P++G +++ + +ME Sbjct: 219 FGVVLWEIATLAEQPYQGLSNEQVLRFVME 248 >2PZI-A nrPDB Length = 681 Score = 57.0 bits (136), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 41/122 (33%), Positives = 57/122 (46%), Gaps = 12/122 (9%) Query: 401 PFLTQLHSCFQTMDRL-----YFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 455 P + Q+ + + DR Y VMEYV G L Q + A+ Y EI L Sbjct: 139 PSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSLKRSKGQ--KLPVAEAIAYLLEILPALS 196 Query: 456 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAY 515 +L S G++Y DLK +N+ML +E +K+ D G G GTP + APEI+ Sbjct: 197 YLHSIGLVYNDLKPENIML-TEEQLKLIDLGAVSRINSFGY----LYGTPGFQAPEIVRT 251 Query: 516 QP 517 P Sbjct: 252 GP 253 >2DMG-A nrPDB Length = 142 Score = 56.6 bits (135), Expect = 3e-08, Method: Composition-based stats. Identities = 28/79 (35%), Positives = 47/79 (59%), Gaps = 1/79 (1%) Query: 161 RIYIQAHIDREVLIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLN 220 ++ I+ R LIVVV +NL+ +G SDPYV++ L+PD + ++KT K +LN Sbjct: 14 QLTIRHSSQRNKLIVVVHACRNLIAFSEDG-SDPYVRMYLLPDKRRSGRRKTHVSKKTLN 72 Query: 221 PEWNETFRFQLKESDKDRR 239 P ++++F F + + RR Sbjct: 73 PVFDQSFDFSVSLPEVQRR 91 >2KI6-A nrPDB Length = 128 Score = 56.6 bits (135), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 38/112 (33%), Positives = 63/112 (56%), Gaps = 4/112 (3%) Query: 173 LIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLK 232 L+V + A L +D G SDPYVK+ L+PD K K +TK + +LNP +NE F F++ Sbjct: 19 LLVGIIQAAELPALDMGGTSDPYVKVFLLPDKK--KKFETKVHRKTLNPVFNEQFTFKVP 76 Query: 233 ESD-KDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKAGV-DGWFKLLSQEE 282 S+ + L + ++D+D S++D +G ++ + V + W L S E+ Sbjct: 77 YSELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNTVDFGHVTEEWRDLQSAEK 128 >3FME-A nrPDB Length = 290 Score = 56.6 bits (135), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 67/282 (23%), Positives = 120/282 (42%), Gaps = 33/282 (11%) Query: 337 MKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDV-------VIQDDDVECTMV 389 +K D +M LG+G++G V + ++ AVK ++ V ++ D D+ V Sbjct: 4 VKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTV 63 Query: 390 EKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKE-PHAVF--Y 446 + PF + ++ ME ++ ++ Q + + + P + Sbjct: 64 D---------CPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKI 114 Query: 447 AAEIAIGLFFLQSK-GIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTP 505 A I L L SK +I+RD+K NV++++ G +K+ DFG+ + D V G Sbjct: 115 AVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISG-YLVDDVAKDIDAGCK 173 Query: 506 DYIAPEII----AYQPYGKSVDWWAFGVLLYEMLAGQAPFE--GEDEDELFQSIMEHNVA 559 Y+APE I + Y D W+ G+ + E+ + P++ G +L Q + E + Sbjct: 174 PYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQ 233 Query: 560 YPKS-MSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFF 600 P S E V + K+ +R PE + +H FF Sbjct: 234 LPADKFSAEFVDFTSQCLKKNSKER-PTYPE----LMQHPFF 270 >6EII-A nrPDB Length = 352 Score = 56.2 bits (134), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 39/126 (30%), Positives = 61/126 (48%), Gaps = 6/126 (4%) Query: 418 FVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSE 477 V E+VN D Q + + FY EI L + S GI++RD+K NVM+D E Sbjct: 134 LVFEHVNNTDFKQLYQTLTDYD---IRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHE 190 Query: 478 GH-IKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA-YQPYGKSVDWWAFGVLLYEML 535 +++ D+G+ E G + + PE++ YQ Y S+D W+ G +L M+ Sbjct: 191 HRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMI 249 Query: 536 AGQAPF 541 + PF Sbjct: 250 FRKEPF 255 >1RSY-A nrPDB Length = 152 Score = 56.2 bits (134), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 38/111 (34%), Positives = 62/111 (55%), Gaps = 4/111 (3%) Query: 173 LIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLK 232 L+V + A L +D G SDPYVK+ L+PD K K +TK + +LNP +NE F F++ Sbjct: 44 LLVGIIQAAELPALDMGGTSDPYVKVFLLPDKK--KKFETKVHRKTLNPVFNEQFTFKVP 101 Query: 233 ESD-KDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKAGV-DGWFKLLSQE 281 S+ + L + ++D+D S++D +G ++ + V + W L S E Sbjct: 102 YSELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNTVDFGHVTEEWRDLQSAE 152 >3F01-A nrPDB Length = 143 Score = 56.2 bits (134), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 33/86 (38%), Positives = 53/86 (61%), Gaps = 3/86 (3%) Query: 173 LIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLK 232 L+V + A L +D G SDPYVK+ L+PD K K +TK + +LNP +NE F F++ Sbjct: 36 LLVGIIQAAELPALDMGGTSDPYVKVFLLPDKK--KKFETKVHRKTLNPVFNEQFTFKVP 93 Query: 233 ESD-KDRRLSVEIWDWDLTSRNDFMG 257 S+ + L + ++D+D S++D +G Sbjct: 94 YSELGGKTLVMAVYDFDRFSKHDIIG 119 >4MD7-E nrPDB Length = 391 Score = 56.2 bits (134), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 39/126 (30%), Positives = 61/126 (48%), Gaps = 6/126 (4%) Query: 418 FVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSE 477 V E+VN D Q + + FY EI L + S GI++RD+K NVM+D E Sbjct: 111 LVFEHVNNTDFKQLYQTLTDYD---IRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHE 167 Query: 478 GH-IKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA-YQPYGKSVDWWAFGVLLYEML 535 +++ D+G+ E G + + PE++ YQ Y S+D W+ G +L M+ Sbjct: 168 HRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMI 226 Query: 536 AGQAPF 541 + PF Sbjct: 227 FRKEPF 232 >4Y12-A nrPDB Length = 375 Score = 55.5 bits (132), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 41/122 (33%), Positives = 56/122 (45%), Gaps = 12/122 (9%) Query: 401 PFLTQLHSCFQTMDRL-----YFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 455 P + Q+ + + DR Y VMEYV G L Q + A+ Y EI L Sbjct: 178 PSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSLKRSKGQ--KLPVAEAIAYLLEILPALS 235 Query: 456 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAY 515 +L S G++Y DLK +N+ML E +K+ D G G GTP + APEI+ Sbjct: 236 YLHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINSFGY----LYGTPGFQAPEIVRT 290 Query: 516 QP 517 P Sbjct: 291 GP 292 >5M07-A nrPDB Length = 276 Score = 55.1 bits (131), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 52/214 (24%), Positives = 89/214 (41%), Gaps = 25/214 (11%) Query: 337 MKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLAL 396 + + + +LG + G+V L + G A+K+L + D+ E V A Sbjct: 27 VTFAGYTVVRMLGASAMGEVYLVQHPGFPGWQALKVLSPAMAADDEFRRRFQRETEVAAR 86 Query: 397 PGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQ----QVGRFKEPHAVFYAAEIAI 452 P L ++H + +L+ M+YV+G D H+ V E A+ A +A Sbjct: 87 LFHPHIL-EVHDRGEFDGQLWIAMDYVDGIDATQHMADRFPAVLPVGEVLAIVTA--VAG 143 Query: 453 GLFFLQSKGIIYRDLKLDNVMLDSEG----HIKIADFGMCKENIWDGVTTKTFCGTPDYI 508 L + +G+++RD+ NV+L S+ I +ADFG+ + P Y Sbjct: 144 ALDYAHQRGLLHRDVNPANVVLTSQSAGDQRILLADFGIASQ--------------PSYP 189 Query: 509 APEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFE 542 APE+ A D +A + + AG P + Sbjct: 190 APELSAGADVDGRADQYALALTAIHLFAGAPPVD 223 >3RP9-A nrPDB Length = 458 Score = 55.1 bits (131), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 51/227 (22%), Positives = 94/227 (41%), Gaps = 46/227 (20%) Query: 347 VLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQL 406 ++G GS+G V + K + A+K K + + +D ++C + + + L L Sbjct: 60 LIGTGSYGHVCEAYDKLEKRVVAIK---KILRVFEDLIDCKRILREIAILNR----LNHD 112 Query: 407 HSC----------FQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFF 456 H + D LY V+E + D + E H + +G+ + Sbjct: 113 HVVKVLDIVIPKDVEKFDELYVVLE-IADSDFKKLFRTPVYLTELHIKTLLYNLLVGVKY 171 Query: 457 LQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIW--------------DGVTTKTFC 502 + S GI++RDLK N +++ + +K+ DFG+ + + D + TF Sbjct: 172 VHSAGILHRDLKPANCLVNQDCSVKVCDFGLARTVDYPENGNSQLPISPREDDMNLVTFP 231 Query: 503 GTPD-------------YIAPEIIAYQP-YGKSVDWWAFGVLLYEML 535 T + Y APE+I Q Y +++D W+ G + E+L Sbjct: 232 HTKNLKRQLTGHVVTRWYRAPELILLQENYTEAIDVWSIGCIFAELL 278 >3Q4U-A nrPDB Length = 301 Score = 55.1 bits (131), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 62/217 (28%), Positives = 92/217 (42%), Gaps = 32/217 (14%) Query: 341 DFNFLMVLGKGSFGKVMLSERKGTDELYAVKILK---KDVVIQDDDVECTMVEKRVLALP 397 D L +GKG +G+V +G E AVKI + ++ ++ T++ + L Sbjct: 9 DITLLECVGKGRYGEVWRGSWQG--ENVAVKIFSSRDEKSWFRETELYNTVMLRHENILG 66 Query: 398 GKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGL--- 454 +T HS Q L+ + Y G L Y Q+ + IA GL Sbjct: 67 FIASDMTSRHSSTQ----LWLITHYHEMGSL-YDYLQLTTLDTVSCLRIVLSIASGLAHL 121 Query: 455 ----FFLQSK-GIIYRDLKLDNVMLDSEGHIKIADFGMC-----KENIWDGVTTKTFCGT 504 F Q K I +RDLK N+++ G IAD G+ N D V GT Sbjct: 122 HIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLD-VGNNPRVGT 180 Query: 505 PDYIAPEII-------AYQPYGKSVDWWAFGVLLYEM 534 Y+APE++ + Y K VD WAFG++L+E+ Sbjct: 181 KRYMAPEVLDETIQVDCFDSY-KRVDIWAFGLVLWEV 216 >1UGK-A nrPDB Length = 138 Score = 54.3 bits (129), Expect = 2e-07, Method: Composition-based stats. Identities = 30/107 (28%), Positives = 64/107 (59%), Gaps = 5/107 (4%) Query: 164 IQAHIDREVLIVVVRDAKNLVPMDPNGL-SDPYVKLKLIPDPKSESKQKTKTIKCSLNPE 222 ++ + +R+ +V +++A+ L MD + SDPY+K+ ++P+ K K KT+ ++ +L+P Sbjct: 15 LEYNFERKAFVVNIKEARGLPAMDEQSMTSDPYIKMTILPEKKH--KVKTRVLRKTLDPA 72 Query: 223 WNETFRFQLKESDKDRRLSVE--IWDWDLTSRNDFMGSLSFGISELQ 267 ++ETF F + + L++ I +D SR+D +G + +S ++ Sbjct: 73 FDETFTFYGIPYTQIQELALHFTILSFDRFSRDDIIGEVLIPLSGIE 119 >4RT7-A nrPDB Length = 415 Score = 54.3 bits (129), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 33/114 (28%), Positives = 62/114 (54%), Gaps = 3/114 (2%) Query: 446 YAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDG-VTTKTFCGT 504 +A ++A G+ FL+ K ++RDL NV++ +KI DFG+ ++ + D + Sbjct: 248 FAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARL 307 Query: 505 P-DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIMEH 556 P ++APE + Y D W++G+LL+E+ + G P+ G D F ++++ Sbjct: 308 PVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQN 361 Score = 36.6 bits (83), Expect = 0.032, Method: Compositional matrix adjust. Identities = 33/120 (27%), Positives = 49/120 (40%), Gaps = 16/120 (13%) Query: 341 DFNFLMVLGKGSFGKVMLS-----ERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 395 + F VLG G+FGKVM + + G AVK+LK+ + E M E +++ Sbjct: 66 NLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKA--DSSEREALMSELKMMT 123 Query: 396 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLM---------YHIQQVGRFKEPHAVFY 446 G + L +Y + EY GDL+ +H FKE + FY Sbjct: 124 QLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFY 183 >3EB0-A nrPDB Length = 383 Score = 54.3 bits (129), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 34/112 (30%), Positives = 60/112 (53%), Gaps = 4/112 (3%) Query: 445 FYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGH-IKIADFGMCKENIWDGVTTKTFCG 503 Y ++ + F+ S GI +RD+K N++++S+ + +K+ DFG K+ I + C Sbjct: 145 IYIYQLFRAVGFIHSLGICHRDIKPQNLLVNSKDNTLKLCDFGSAKKLIPSEPSVAYICS 204 Query: 504 TPDYIAPEI-IAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDE-DELFQSI 553 Y APE+ + Y S+D W+ G + E++ G+ F GE D+L + I Sbjct: 205 R-FYRAPELMLGATEYTPSIDLWSIGCVFGELILGKPLFSGETSIDQLVRII 255 >3FDW-A nrPDB Length = 148 Score = 54.3 bits (129), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 37/119 (31%), Positives = 60/119 (50%), Gaps = 12/119 (10%) Query: 160 GRIYIQAHIDREV--LIVVVRDAKNLVPMD-PNGLSDPYVKLKLIPDPKSESKQKTKTIK 216 GRI +++ L+V V++ L D S+PYVK L+PD + K+KT + Sbjct: 10 GRIAFSLKYEQQTQSLVVHVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQGKRKTSIKR 69 Query: 217 CSLNPEWNETFRFQLKES-DKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKAGVDGW 274 ++NP ++ET R+++ ES R L +W RN F+G +E+Q +D W Sbjct: 70 DTVNPLYDETLRYEIPESLLAQRTLQFSVWHHGRFGRNTFLGE-----AEIQ---MDSW 120 >6NYT-A nrPDB Length = 148 Score = 53.9 bits (128), Expect = 2e-07, Method: Composition-based stats. Identities = 37/114 (32%), Positives = 56/114 (49%), Gaps = 19/114 (16%) Query: 175 VVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKES 234 + V A+ L D G SDPYV +++ ++K++TKTI +LNP W E F F+ S Sbjct: 21 ITVVCAQGLQAKDKTGSSDPYVTVQV-----GKTKKRTKTIYGNLNPVWEENFHFECHNS 75 Query: 235 DKDRRLSVEIWDW--DLTSR---------NDFMGSLSFGISELQKAGVDGWFKL 277 R+ V +WD D+ SR +DF+G + L +D W+ L Sbjct: 76 SD--RIKVRVWDEDDDIKSRVKQRFKRESDDFLGQTIIEVRTLS-GEMDVWYNL 126 >5XD6-A nrPDB Length = 305 Score = 53.5 bits (127), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 60/217 (27%), Positives = 94/217 (43%), Gaps = 34/217 (15%) Query: 347 VLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDD---VECTMV----EKRVLALPGK 399 ++G+GS+G+V K A I K D Q D + +MV ++ V+AL G Sbjct: 29 LIGEGSYGRVFYGILKSGK---AAAIKKLDSSKQPDQEFLAQVSMVSRLRQENVVALLGY 85 Query: 400 PPFLTQLHSCFQTMDRLYFVMEYVNGGDL--MYHIQQVGRFKEPHAVF-------YAAEI 450 C R+ EY G L + H ++ + +P V A Sbjct: 86 ---------CVDGPLRV-LAYEYAPNGSLHDILHGRKGVKGAQPGPVLSWHQRVKIAVGA 135 Query: 451 AIGLFFLQSKG---IIYRDLKLDNVMLDSEGHIKIADFGMCKE--NIWDGVTTKTFCGTP 505 A GL +L K +I+RD+K NV+L + KIADF + + ++ + + GT Sbjct: 136 ARGLEYLHEKANPHVIHRDIKSSNVLLFDDDVAKIADFDLSNQAPDMAARLHSTRVLGTF 195 Query: 506 DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFE 542 Y APE D ++FGV+L E+L G+ P + Sbjct: 196 GYHAPEYAMTGTLSTKSDVYSFGVVLLELLTGRKPVD 232 >6O6Q-A nrPDB Length = 335 Score = 53.5 bits (127), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 53/218 (24%), Positives = 97/218 (44%), Gaps = 14/218 (6%) Query: 341 DFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKP 400 ++ L LG+G + +V L E +K+LK V + E ++++ L P Sbjct: 42 NYEILRKLGRGKYSEVFLGIDLEKREKVVIKVLKP-VKRKKIKREISILKN----LVDGP 96 Query: 401 PFLTQLHSCFQTMDRL-YFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQS 459 + L + + + E++N D F + FY E+ L + S Sbjct: 97 NIIAMLDVVREPQSKTPGLIFEHINNIDFR---SLYPTFTDYDIRFYMYELLKALDYSHS 153 Query: 460 KGIIYRDLKLDNVMLDSEGH-IKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA-YQP 517 GI++RD+K NVM+D + +++ D+G+ E G + + PE++ Y+ Sbjct: 154 MGIMHRDVKPHNVMIDHDKKLLRLIDWGLA-EYYHPGTEYNVRVASRYFKGPELLVDYRL 212 Query: 518 YGKSVDWWAFGVLLYEMLAGQAPF--EGEDEDELFQSI 553 Y S+D W+FG +L M+ + PF + D+L Q + Sbjct: 213 YDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQLVQIV 250 >3HMP-A nrPDB Length = 342 Score = 53.5 bits (127), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 74/320 (23%), Positives = 134/320 (41%), Gaps = 36/320 (11%) Query: 292 PEGSEGNEELRQKFERAKIGQGTKAPEEKTANTISKFDNNGNRDRMKLTDFNFLMVLGKG 351 P GS E KFER Q +P+ T + + +K ++ L +G G Sbjct: 12 PRGSGMKETAAAKFER----QHMDSPDLGTDDDDKASSSANECISVKGRIYSILKQIGSG 67 Query: 352 SFGKV--MLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK----PPFLTQ 405 KV +L+E+K ++YA+K V +++ D + + +A K + + Sbjct: 68 GSSKVFQVLNEKK---QIYAIKY----VNLEEADNQTLDSYRNEIAYLNKLQQHSDKIIR 120 Query: 406 LHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYR 465 L+ T +Y VME N DL +++ Y + + + GI++ Sbjct: 121 LYDYEITDQYIYMVMECGNI-DLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHS 179 Query: 466 DLKLDNVMLDSEGHIKIADFGMCKENIWD--GVTTKTFCGTPDYIAPEIIAYQPYGKS-- 521 DLK N ++ +G +K+ DFG+ + D V + GT +Y+ PE I + Sbjct: 180 DLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENG 238 Query: 522 ---------VDWWAFGVLLYEMLAGQAPFEG-EDEDELFQSIME--HNVAYPKSMSKEAV 569 D W+ G +LY M G+ PF+ ++ +I++ H + +P K+ Sbjct: 239 KSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPEKDLQ 298 Query: 570 AICKGLMTKHPGKRLGCGPE 589 + K + + P +R+ PE Sbjct: 299 DVLKCCLKRDPKQRISI-PE 317 >2JD5-A nrPDB Length = 373 Score = 52.8 bits (125), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 58/251 (23%), Positives = 109/251 (43%), Gaps = 52/251 (20%) Query: 341 DFNFLMV--LGKGSFGKVMLSERKGTDELYAVKILKKDVVI----------------QDD 382 D +++V LG G F V L++ + A+KI++ D V D+ Sbjct: 18 DARYILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVRGDKVYTEAAEDEIKLLQRVNDADN 77 Query: 383 DVECTMVEKRVLAL----PGKPPFLTQLHSCFQTM--DRLYFVMEYVNGGDLMYHIQQVG 436 E +M +L L K P + F+ + + L + +Y + G + +++Q+ Sbjct: 78 TKEDSMGANHILKLLDHFNHKGPNGVHVVMVFEVLGENLLALIKKYEHRGIPLIYVKQIS 137 Query: 437 RFKEPHAVFYAAEIAIGLFFLQSK-GIIYRDLKLDNVMLD------SEGHIKIADFGMCK 489 + ++ +GL ++ + GII+ D+K +NV+++ + IKIAD G Sbjct: 138 K-----------QLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNA- 185 Query: 490 ENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFE------- 542 W T +Y +PE++ P+G D W+ L++E++ G FE Sbjct: 186 --CWYDEHYTNSIQTREYRSPEVLLGAPWGCGADIWSTACLIFELITGDFLFEPDEGHSY 243 Query: 543 GEDEDELFQSI 553 +D+D + Q I Sbjct: 244 TKDDDHIAQII 254 >5WNL-A nrPDB Length = 342 Score = 52.8 bits (125), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 42/150 (28%), Positives = 73/150 (48%), Gaps = 20/150 (13%) Query: 418 FVMEYVNGGDLMYHIQQVG-----RFKEPHAVFYAAEIAIGLFFLQ--SKGIIYRDLKLD 470 VMEY+ G L + RF+ H E A+G+ FL S +++ +LK Sbjct: 94 LVMEYMETGSLEKLLASEPLPWDLRFRIVH------ETAVGMNFLHCMSPPLLHLNLKPA 147 Query: 471 NVMLDSEGHIKIADFGMCKENIWD---GVTTKTFCGTPDYIAPEIIAYQP--YGKSVDWW 525 N++LD+ H+KI+DFG+ K N ++ GT Y+ PE I + + D + Sbjct: 148 NILLDAHYHVKISDFGLAKCNGMSHSHDLSMDGLFGTIAYLPPERIREKSRLFDTKHDVY 207 Query: 526 AFGVLLYEMLAGQAPFEGEDEDELFQSIME 555 +F ++++ +L + PF DE + +M+ Sbjct: 208 SFAIVIWGVLTQKKPF--ADEKNILHIMMK 235 >2RIO-A nrPDB Length = 434 Score = 52.8 bits (125), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 68/274 (24%), Positives = 125/274 (45%), Gaps = 45/274 (16%) Query: 347 VLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQL 406 +LG GS G V+ +G+ + V + K ++I D + ++E ++L P + + Sbjct: 22 ILGYGSSGTVVF---QGSFQGRPVAV--KRMLI--DFCDIALMEIKLLTESDDHPNVIRY 74 Query: 407 HSCFQTMDR-LYFVMEY--VNGGDLM----YHIQQVGRFKEPHAVFYAAEIAIGLFFLQS 459 + C +T DR LY +E +N DL+ + + KE + + +IA G+ L S Sbjct: 75 Y-CSETTDRFLYIALELCNLNLQDLVESKNVSDENLKLQKEYNPISLLRQIASGVAHLHS 133 Query: 460 KGIIYRDLKLDNVMLDSEG-------------HIKIADFGMCKENIWDGVTTKTFC---- 502 II+RDLK N+++ + I I+DFG+CK+ + +T Sbjct: 134 LKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFRTNLNNPS 193 Query: 503 GTPDYIAPEII-------AYQPYGKSVDWWAFGVLLYEMLA-GQAPF--EGEDEDELFQS 552 GT + APE++ + +S+D ++ G + Y +L+ G+ PF + E + + Sbjct: 194 GTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPFGDKYSRESNIIRG 253 Query: 553 IM---EHNVAYPKSMSKEAVAICKGLMTKHPGKR 583 I E + +S+ EA + ++ P KR Sbjct: 254 IFSLDEMKCLHDRSLIAEATDLISQMIDHDPLKR 287 >5IKW-A nrPDB Length = 310 Score = 52.8 bits (125), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 45/148 (30%), Positives = 66/148 (44%), Gaps = 20/148 (13%) Query: 416 LYFVMEYVNGGDLMYHIQ---QVGRFKEPHA--VFYAAEIAIGLFFLQSKGIIYRDLKLD 470 + +MEY G ++ + Q G F EP +F A+ II+RDLK++ Sbjct: 91 VLILMEYCRAGQVVNQMNKKLQTG-FTEPEVLQIFCDTCEAVARLHQCKTPIIHRDLKVE 149 Query: 471 NVMLDSEGHIKIADFGMCKENIW----DGVTT-----KTFCGTPDYIAPEIIAY---QPY 518 N++L+ G+ + DFG DGV K + T Y APE+I +P Sbjct: 150 NILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKY-TTLSYRAPEMINLYGGKPI 208 Query: 519 GKSVDWWAFGVLLYEMLAGQAPFEGEDE 546 D WA G LLY++ PF GE + Sbjct: 209 TTKADIWALGCLLYKLCFFTLPF-GESQ 235 >5XVU-A nrPDB Length = 332 Score = 52.4 bits (124), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 36/126 (28%), Positives = 60/126 (47%), Gaps = 6/126 (4%) Query: 418 FVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSE 477 + EY+N D +F + +Y +I L + S+GI++RD+K N+M+D E Sbjct: 105 LIFEYINNIDFK---TLYPKFTDKDIRYYIYQILKALDYCHSQGIMHRDVKPHNIMIDHE 161 Query: 478 G-HIKIADFGMCKENIWDGVTTKTFCGTPDYIAPE-IIAYQPYGKSVDWWAFGVLLYEML 535 I++ +G+ E G + Y PE +I Q Y S+D W+ G +L M+ Sbjct: 162 NRQIRLISWGLA-EFYHPGQEYNVRVASRYYKGPELLIDLQLYDYSLDIWSLGCMLAGMI 220 Query: 536 AGQAPF 541 + PF Sbjct: 221 FKKEPF 226 >3QD2-B nrPDB Length = 332 Score = 52.4 bits (124), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 31/99 (31%), Positives = 49/99 (49%), Gaps = 12/99 (12%) Query: 449 EIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDG------------V 496 +IA + FL SKG+++RDLK N+ + +K+ DFG+ D Sbjct: 172 QIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYA 231 Query: 497 TTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEML 535 T GT Y++PE I Y VD ++ G++L+E+L Sbjct: 232 THTGQVGTKLYMSPEQIHGNNYSHKVDIFSLGLILFELL 270 Score = 29.3 bits (64), Expect = 6.4, Method: Compositional matrix adjust. Identities = 14/36 (38%), Positives = 22/36 (61%) Query: 339 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILK 374 LTDF + +G+G FG V ++ K D YA+K ++ Sbjct: 5 LTDFEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIR 40 >4LFI-A nrPDB Length = 374 Score = 51.6 bits (122), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 36/128 (28%), Positives = 64/128 (50%), Gaps = 10/128 (7%) Query: 418 FVMEYVNGGD--LMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLD 475 V EYV+ D ++Y + + FY E+ L + S GI++RD+K NVM+D Sbjct: 152 LVFEYVDNVDFRILY-----PKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMID 206 Query: 476 SEG-HIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA-YQPYGKSVDWWAFGVLLYE 533 + +++ D+G+ E + + + PE++ Y+ Y S+D W+FG +L Sbjct: 207 HKNKKLRLIDWGLA-EFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLAS 265 Query: 534 MLAGQAPF 541 M+ + PF Sbjct: 266 MIFKREPF 273 >5X8I-B nrPDB Length = 346 Score = 51.6 bits (122), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 62/247 (25%), Positives = 97/247 (39%), Gaps = 29/247 (11%) Query: 342 FNFLMVLGKGSFGKVM-LSERKGTDELYAVKILKK-DVVIQDDDVECTMVEKRVLALPGK 399 + + LG+G+FGKV+ + K AVKI+K D + E ++E P Sbjct: 15 YEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNS 74 Query: 400 PPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVG--RFKEPHAVFYAAEIAIGLFFL 457 Q+ F+ + V E + G I++ G F+ H A +I + FL Sbjct: 75 TFRCVQMLEWFEHHGHICIVFELL-GLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFL 133 Query: 458 QSKGIIYRDLKLDNVMLDSEGH-------------------IKIADFGMCKENIWDGVTT 498 S + + DLK +N++ + IK+ DFG +D Sbjct: 134 HSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFG---SATYDDEHH 190 Query: 499 KTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNV 558 T T Y APE+I + + D W+ G +L E G F D E ++ME + Sbjct: 191 STLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHL-AMMERIL 249 Query: 559 A-YPKSM 564 PK M Sbjct: 250 GPLPKHM 256 >5IXC-A nrPDB Length = 814 Score = 51.2 bits (121), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 36/94 (38%), Positives = 51/94 (54%), Gaps = 3/94 (3%) Query: 173 LIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLK 232 L V V +A+NL D +DPYV L+L P K KTKT+ + +P WNE FRF L Sbjct: 28 LTVRVLEARNLRWADLLSEADPYVILQLSTAPGM--KFKTKTLTDTSHPVWNEAFRF-LI 84 Query: 233 ESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISEL 266 +S L + I+D D + +D + + ISE+ Sbjct: 85 QSQVKNVLELSIYDEDSVTEDDICFKVLYDISEV 118 >2ZMD-A nrPDB Length = 390 Score = 50.8 bits (120), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 73/320 (22%), Positives = 133/320 (41%), Gaps = 36/320 (11%) Query: 292 PEGSEGNEELRQKFERAKIGQGTKAPEEKTANTISKFDNNGNRDRMKLTDFNFLMVLGKG 351 P GS E KFER Q +P+ T + + +K ++ L +G G Sbjct: 12 PRGSGMKETAAAKFER----QHMDSPDLGTDDDDKASSSANECISVKGRIYSILKQIGSG 67 Query: 352 SFGKV--MLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK----PPFLTQ 405 KV +L+E+K ++YA+K V +++ D + + +A K + + Sbjct: 68 GSSKVFQVLNEKK---QIYAIKY----VNLEEADNQTLDSYRNEIAYLNKLQQHSDKIIR 120 Query: 406 LHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYR 465 L+ T +Y VME N DL +++ Y + + + GI++ Sbjct: 121 LYDYEITDQYIYMVMECGNI-DLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHS 179 Query: 466 DLKLDNVMLDSEGHIKIADFGMCKENIWD--GVTTKTFCGTPDYIAPEIIAYQPYGK--- 520 DLK N ++ +G +K+ DFG+ + D V + G +Y+ PE I + Sbjct: 180 DLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGAVNYMPPEAIKDMSSSRENG 238 Query: 521 --------SVDWWAFGVLLYEMLAGQAPFEG-EDEDELFQSIME--HNVAYPKSMSKEAV 569 D W+ G +LY M G+ PF+ ++ +I++ H + +P K+ Sbjct: 239 KSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPEKDLQ 298 Query: 570 AICKGLMTKHPGKRLGCGPE 589 + K + + P +R+ PE Sbjct: 299 DVLKCCLKRDPKQRISI-PE 317 >6BFN-A nrPDB Length = 342 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 56/215 (26%), Positives = 95/215 (44%), Gaps = 21/215 (9%) Query: 341 DFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECT-MVEKRVLALPGK 399 +F+ + +G+G FG V + + T +YAVK LK++ ++ V+ + + E L+ Sbjct: 23 NFSEELKIGEGGFGCVYRAVMRNT--VYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRH 80 Query: 400 PPFLTQLHSCFQTMDRLY-FVMEYVNGGDL--MYHIQQVG----RFKEPHAVFYAAEIAI 452 P + C Q + Y V ++ G L H Q + + + AI Sbjct: 81 PNIVDFAGYCAQ--NGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAI 138 Query: 453 GLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVT---------TKTFCG 503 S +I+ D+K NV+LD K+ DFG+ + + + G + T+T G Sbjct: 139 QFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRG 198 Query: 504 TPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQ 538 T Y+ E I D ++FGV++ E LAGQ Sbjct: 199 TLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQ 233 >1Y8F-A nrPDB Length = 66 Score = 50.4 bits (119), Expect = 2e-06, Method: Composition-based stats. Identities = 17/43 (39%), Positives = 29/43 (67%) Query: 101 KHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRC 143 +H F++ T ++PT+C C LL+G+ QGM+C C + H++C Sbjct: 13 QHNFEVWTATTPTYCYECEGLLWGIARQGMRCTECGVKCHEKC 55 Score = 45.4 bits (106), Expect = 8e-05, Method: Composition-based stats. Identities = 15/50 (30%), Positives = 23/50 (46%) Query: 37 HKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSC 86 H F PT+C C +WG +QG +C C H++C + + C Sbjct: 14 HNFEVWTATTPTYCYECEGLLWGIARQGMRCTECGVKCHEKCQDLLNADC 63 >6GVJ-A nrPDB Length = 429 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 59/274 (21%), Positives = 117/274 (42%), Gaps = 47/274 (17%) Query: 342 FNFLMVLGKGSFGKV--MLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK 399 ++ L +G G KV +L+E+K ++YA+K V +++ D + + +A Sbjct: 146 YSILKQIGSGGSSKVFQVLNEKK---QIYAIKY----VNLEEADNQTLDSYRNEIA---- 194 Query: 400 PPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR------FKEPHAV------FYA 447 +L +L + RLY +Y +Y + + G K+ ++ Y Sbjct: 195 --YLNKLQQHSDKIIRLY---DYEITDQYIYMVMECGNIDLNSWLKKKKSIDPWERKSYW 249 Query: 448 AEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWD--GVTTKTFCGTP 505 + + + GI++ DLK N ++ +G +K+ DFG+ + D V + GT Sbjct: 250 KNMLEAVHTIHQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTV 308 Query: 506 DYIAPEIIAYQPYGK-----------SVDWWAFGVLLYEMLAGQAPFEG-EDEDELFQSI 553 +Y+ PE I + D W+ G +LY M G+ PF+ ++ +I Sbjct: 309 NYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAI 368 Query: 554 ME--HNVAYPKSMSKEAVAICKGLMTKHPGKRLG 585 ++ H + +P K+ + K + + P +R+ Sbjct: 369 IDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRIS 402 >3N5A-A nrPDB Length = 138 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 36/88 (40%), Positives = 53/88 (60%), Gaps = 1/88 (1%) Query: 173 LIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQL- 231 +IV + A+NL MD G SDPYVK+ L+ K K+KT T K +LNP +NE+F F + Sbjct: 18 IIVNIIKARNLKAMDIGGTSDPYVKVWLMYKDKRVEKKKTVTKKRNLNPIFNESFAFDIP 77 Query: 232 KESDKDRRLSVEIWDWDLTSRNDFMGSL 259 E ++ + + + D D SRND +G + Sbjct: 78 TEKLRETTIIITVMDKDKLSRNDVIGKI 105 >5A50-A nrPDB Length = 177 Score = 50.4 bits (119), Expect = 3e-06, Method: Composition-based stats. Identities = 32/93 (34%), Positives = 50/93 (53%), Gaps = 8/93 (8%) Query: 172 VLIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQL 231 +L + ++ NL D + SDPYV +K+ + K KT+ I +NPEWNE + Sbjct: 19 LLRIRIKRGVNLAVRDISS-SDPYVVVKM-----GKQKLKTRVINKDVNPEWNEDLTLSV 72 Query: 232 KESDKDRRLSVEIWDWDLTSRNDFMGSLSFGIS 264 +S+ L+V +D D+ S++D MG F IS Sbjct: 73 TDSNLTVLLTV--YDHDMFSKDDKMGDAEFEIS 103 >3REP-A nrPDB Length = 271 Score = 50.4 bits (119), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 63/257 (24%), Positives = 109/257 (42%), Gaps = 28/257 (10%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILK-KDVVIQ---DDDVECTMVEKRVLALP 397 NFL L + G++ +G D VK+LK +D + D + EC + R+ + P Sbjct: 12 LNFLTKLNENHSGELWKGRWQGND--IVVKVLKVRDWSTRKSRDFNEECPRL--RIFSHP 67 Query: 398 GKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRF--KEPHAVFYAAEIAIGLF 455 P L S L + ++ G L + + F + AV +A ++A G+ Sbjct: 68 NVLPVLGACQSPPAPHPTL--ITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMA 125 Query: 456 FLQS-KGIIYRD-LKLDNVMLDSE--GHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPE 511 FL + + +I R L +VM+D + I +AD + + P ++APE Sbjct: 126 FLHTLEPLIPRHALNSRSVMIDEDMTARISMADVKFSFQ-------SPGRMYAPAWVAPE 178 Query: 512 IIAYQPYG---KSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNV--AYPKSMSK 566 + +P +S D W+F VLL+E++ + PF E+ + + P +S Sbjct: 179 ALQKKPEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPTIPPGISP 238 Query: 567 EAVAICKGLMTKHPGKR 583 + K M + P KR Sbjct: 239 HVSKLMKICMNEDPAKR 255 >3MIA-A nrPDB Length = 351 Score = 49.7 bits (117), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 43/202 (21%), Positives = 81/202 (40%), Gaps = 39/202 (19%) Query: 453 GLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCK-----ENIWDGVTTKTFCGTPDY 507 GL+++ I++RD+K NV++ +G +K+ADFG+ + +N T T Y Sbjct: 136 GLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVV-TLWY 194 Query: 508 IAPE-IIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSK 566 PE ++ + YG +D W G ++ EM +G E +H +A + Sbjct: 195 RPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTE--------QHQLALISQL-- 244 Query: 567 EAVAICKGLMTKHPGKRLGCG---PEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARD 623 CG PE ++ + + ++ K ++++++ K RD Sbjct: 245 -------------------CGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRD 285 Query: 624 KRDTSNFDKEFTRQPVELTPTD 645 DK P + +D Sbjct: 286 PYALDLIDKLLVLDPAQRIDSD 307 >5TE0-A nrPDB Length = 347 Score = 49.3 bits (116), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 72/295 (24%), Positives = 118/295 (40%), Gaps = 48/295 (16%) Query: 347 VLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA-LPGKPPFLTQ 405 VL +G F V L + LK+ V + D++ E +++ L G + Sbjct: 26 VLAEGGFAIVFLVRTSNGMKC----ALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGY 81 Query: 406 LHSCFQTMD-----RLYFVMEYVNGG---DLMYHIQQVGRFKEPHA--VFYAAEIAIGLF 455 + S + + +M++ GG +LM Q G F E +F A+ Sbjct: 82 IDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTG-FTENEVLQIFCDTCEAVARL 140 Query: 456 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFC--------GTPDY 507 II+RDLK++N++L GH + DFG + T T Y Sbjct: 141 HQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSY 200 Query: 508 IAPEIIAYQPYGKSV----DWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKS 563 APE++ GK + D WA G LLY++ PF GE + +I + N P + Sbjct: 201 RAPEMVNLYS-GKIITTKADIWALGCLLYKLCYFTLPF-GESQ----VAICDGNFTIPDN 254 Query: 564 --MSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPP 616 S++ + + ++ P KR DI + ++F + KL +KE P Sbjct: 255 SRYSQDMHCLIRYMLEPDPDKR--------PDIYQVSYFSF----KLLKKECPIP 297 >6EQI-C nrPDB Length = 433 Score = 48.9 bits (115), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 43/145 (29%), Positives = 66/145 (45%), Gaps = 20/145 (13%) Query: 461 GIIYRDLKLDNVMLD-SEGH----IKIADFGMCKENIWDGVTT------KTFCGTPDYIA 509 I +RDLK DN+++D SEG I I DFG C + +G+ + G +A Sbjct: 187 NISHRDLKSDNILVDLSEGDAYPTIVITDFGCCLCDKQNGLVIPYRSEDQDKGGNRALMA 246 Query: 510 PEIIAYQP-------YGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNV-AYP 561 PEI +P Y KS D WA G + YE+ PF + L +S E ++ P Sbjct: 247 PEIANAKPGTFSWLNYKKS-DLWAVGAIAYEIFNIDNPFYDKTMKLLSKSYKEEDLPELP 305 Query: 562 KSMSKEAVAICKGLMTKHPGKRLGC 586 ++ + ++++ KRL C Sbjct: 306 DTIPFIIRNLVSNMLSRSTNKRLDC 330 >2Y4I-B nrPDB Length = 319 Score = 48.9 bits (115), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 37/121 (30%), Positives = 59/121 (48%), Gaps = 21/121 (17%) Query: 447 AAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVT--------T 498 A EI G+ +L +KGI+++DLK NV D+ G + I DFG+ + GV Sbjct: 136 AQEIVKGMGYLHAKGILHKDLKSKNVFYDN-GKVVITDFGLFSIS---GVLQAGRREDKL 191 Query: 499 KTFCGTPDYIAPEIIAY---------QPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDEL 549 + G ++APEII P+ K D +A G + YE+ A + PF+ + + + Sbjct: 192 RIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAI 251 Query: 550 F 550 Sbjct: 252 I 252 >3MY0-A nrPDB Length = 305 Score = 48.1 bits (113), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 59/223 (26%), Positives = 95/223 (42%), Gaps = 33/223 (14%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDV---ECTMVEKRVLALPGKPPFLT 404 +GKG +G+V G E AVKI +D+ E + +L F+ Sbjct: 16 VGKGRYGEVWRGLWHG--ESVAVKIFSS----RDEQSWFRETEIYNTVLLRHDNILGFIA 69 Query: 405 QLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPH-AVFYAAEIAIGLFFLQSK--- 460 + + +L+ + Y G L +Q+ + EPH A+ A A GL L + Sbjct: 70 SDMTSRNSSTQLWLITHYHEHGSLYDFLQR--QTLEPHLALRLAVSAACGLAHLHVEIFG 127 Query: 461 -----GIIYRDLKLDNVMLDSEGHIKIADFGMC----KENIWDGVTTKTFCGTPDYIAPE 511 I +RD K NV++ S IAD G+ + + + + GT Y+APE Sbjct: 128 TQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPE 187 Query: 512 II-------AYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDED 547 ++ ++ Y K D WAFG++L+E +A + G ED Sbjct: 188 VLDEQIRTDCFESY-KWTDIWAFGLVLWE-IARRTIVNGIVED 228 >2PVN-A nrPDB Length = 352 Score = 48.1 bits (113), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 34/126 (26%), Positives = 59/126 (46%), Gaps = 6/126 (4%) Query: 418 FVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSE 477 + EYVN D + + +Y E+ L + S+GI++RD+K NVM+D E Sbjct: 126 LIFEYVNNTDFKVLYPTLTDYD---IRYYIYELLKALDYCHSQGIMHRDVKPHNVMIDHE 182 Query: 478 -GHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA-YQPYGKSVDWWAFGVLLYEML 535 +++ D+G+ E G + + PE++ Q Y S+D W+ G + M+ Sbjct: 183 LRKLRLIDWGLA-EFYHPGKEYNVRVASRYFKGPELLVDLQDYDYSLDMWSLGCMFAGMI 241 Query: 536 AGQAPF 541 + PF Sbjct: 242 FRKEPF 247 >5AP3-A nrPDB Length = 313 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 61/278 (21%), Positives = 119/278 (42%), Gaps = 48/278 (17%) Query: 342 FNFLMVLGKGSFGKV--MLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK 399 ++ L +G G KV +L+E+K ++YA+K V +++ D + + +A Sbjct: 30 YSILKQIGSGGSSKVFQVLNEKK---QIYAIKY----VNLEEADNQTLDSYRNEIA---- 78 Query: 400 PPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR------FKEPHAV------FYA 447 +L +L + RLY +Y +Y + + G K+ ++ Y Sbjct: 79 --YLNKLQQHSDKIIRLY---DYEITDQYIYMVMECGNIDLNGWLKKKKSIDPWERKSYW 133 Query: 448 AEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWD--GVTTKTFCGTP 505 + + + GI++ DLK N ++ +G +K+ DFG+ + D V + GT Sbjct: 134 KNMLEAVHTIHQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTV 192 Query: 506 DYIAPEIIAYQPYGKS-----------VDWWAFGVLLYEMLAGQAPFEG-EDEDELFQSI 553 +Y+ PE I + D W+ G +LY M G+ PF+ ++ +I Sbjct: 193 NYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAI 252 Query: 554 ME--HNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPE 589 ++ H + +P K+ + K + + P +R+ PE Sbjct: 253 IDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRISI-PE 289 >4CRL-A nrPDB Length = 406 Score = 47.8 bits (112), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 31/107 (28%), Positives = 52/107 (48%), Gaps = 8/107 (7%) Query: 449 EIAIGLFFLQSKGIIYRDLKLDNVMLDSEG----HIKIADFGMCK---ENIWDGVTTKTF 501 +I G+ +L + +++RDLK N+++ EG +KIAD G + + Sbjct: 137 QILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPV 196 Query: 502 CGTPDYIAPEII-AYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDED 547 T Y APE++ + Y K++D WA G + E+L + F ED Sbjct: 197 VVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQED 243 >5A52-A nrPDB Length = 168 Score = 47.4 bits (111), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 30/98 (30%), Positives = 51/98 (52%), Gaps = 8/98 (8%) Query: 172 VLIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQL 231 +L + V+ NL D + SDPY+ + + K KT+ +K S+NPEWN+ + Sbjct: 7 LLRIHVKRGVNLAIRDISS-SDPYIVVHC-----GKQKLKTRVVKHSVNPEWNDDLTLSV 60 Query: 232 KESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKA 269 +D + + + ++D+DL S +D MG F I +A Sbjct: 61 --TDPNLPIKLTVYDYDLLSADDKMGEAEFHIGPFIEA 96 >4M69-B nrPDB Length = 283 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 33/150 (22%), Positives = 64/150 (42%), Gaps = 6/150 (4%) Query: 418 FVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSE 477 VMEY G L + + A GL+ L ++R++ + ++ Sbjct: 89 IVMEYCELGTLRELLDREKDLTMSVRSLLVLRAARGLYRLHHSETLHRNISSSSFLVAGG 148 Query: 478 GHIKIADFGMCKENIWDGVTTKTF----CGTPDYIAPEIIA--YQPYGKSVDWWAFGVLL 531 +K+A F + K T K+ + Y++PE + + Y + ++FG++L Sbjct: 149 YQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDIKAEIYSFGIVL 208 Query: 532 YEMLAGQAPFEGEDEDELFQSIMEHNVAYP 561 +E+ G+ PFEG D ++ + + E P Sbjct: 209 WEIATGKIPFEGCDSKKIRELVAEDKKQEP 238 >3RAW-A nrPDB Length = 381 Score = 46.6 bits (109), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 54/226 (23%), Positives = 93/226 (41%), Gaps = 31/226 (13%) Query: 348 LGKGSFGKVM--LSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQ 405 LG+G+FGKV+ L +G ++ A+KI++ ++ V K++ + FL Sbjct: 59 LGEGTFGKVVECLDHARGKSQV-ALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCV 117 Query: 406 LHS-CFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKE---PHAVFYAAEIAIGLFFLQSKG 461 L S F + E + G + + F+ PH A ++ L FL Sbjct: 118 LMSDWFNFHGHMCIAFELL--GKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQ 175 Query: 462 IIYRDLKLDNVM-LDSE------------------GHIKIADFGMCKENIWDGVTTKTFC 502 + + DLK +N++ ++SE I++ADFG +D T Sbjct: 176 LTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSA---TFDHEHHTTIV 232 Query: 503 GTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDE 548 T Y PE+I + + D W+ G +L+E G F+ + E Sbjct: 233 ATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENRE 278 >5VC6-A nrPDB Length = 289 Score = 46.6 bits (109), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 36/139 (25%), Positives = 64/139 (46%), Gaps = 5/139 (3%) Query: 340 TDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK 399 T+F+ L +G G FG V ++ +YA+K KK + D+ + + E A+ G+ Sbjct: 11 TEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDE-QNALREVYAHAVLGQ 69 Query: 400 PPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR----FKEPHAVFYAAEIAIGLF 455 + + S + D + EY NGG L I + R FKE ++ GL Sbjct: 70 HSHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLR 129 Query: 456 FLQSKGIIYRDLKLDNVML 474 ++ S +++ D+K N+ + Sbjct: 130 YIHSMSLVHMDIKPSNIFI 148 >6FYV-A nrPDB Length = 337 Score = 46.6 bits (109), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 58/239 (24%), Positives = 91/239 (38%), Gaps = 34/239 (14%) Query: 334 RDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELY-AVKILKKDVVIQDD-DVECTMVEK 391 R R ++ D LG+G+FGKV+ G D ++ AVKI+K ++ E ++E Sbjct: 13 RARYEIVD-----TLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEH 67 Query: 392 RVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRF---KEPHAVFYAA 448 P Q+ F + V E + G Y + F + H A Sbjct: 68 LNSTDPNSVFRCVQMLEWFDHHGHVCIVFELL--GLSTYDFIKENSFLPFQIDHIRQMAY 125 Query: 449 EIAIGLFFLQSKGIIYRDLKLDNVMLDSEGH-------------------IKIADFGMCK 489 +I + FL + + DLK +N++ + IK+ DFG Sbjct: 126 QICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFG--- 182 Query: 490 ENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDE 548 +D T T Y APE+I + + D W+ G +L E G F+ D E Sbjct: 183 SATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKE 241 >4BTF-A nrPDB Length = 469 Score = 46.2 bits (108), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 33/150 (22%), Positives = 64/150 (42%), Gaps = 6/150 (4%) Query: 418 FVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSE 477 VMEY G L + + A GL+ L ++R++ + ++ Sbjct: 275 IVMEYCELGTLRELLDREKDLTMSVRSLLVLRAARGLYRLHHSETLHRNISSSSFLVAGG 334 Query: 478 GHIKIADFGMCKENIWDGVTTKTF----CGTPDYIAPEIIA--YQPYGKSVDWWAFGVLL 531 +K+A F + K T K+ + Y++PE + + Y + ++FG++L Sbjct: 335 YQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDIKAEIYSFGIVL 394 Query: 532 YEMLAGQAPFEGEDEDELFQSIMEHNVAYP 561 +E+ G+ PFEG D ++ + + E P Sbjct: 395 WEIATGKIPFEGCDSKKIRELVAEDKKQEP 424 >3JZY-A nrPDB Length = 510 Score = 46.2 bits (108), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 29/95 (30%), Positives = 53/95 (55%), Gaps = 6/95 (6%) Query: 173 LIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLK 232 L+V V +A L PNG S+PY ++ + T+TI+ +LNP+WN +F +K Sbjct: 389 LMVHVIEATELKACKPNGKSNPYCEISM-----GSQSYTTRTIQDTLNPKWNFNCQFFIK 443 Query: 233 ESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQ 267 + +D L + ++D D S +DF+G +++++ Sbjct: 444 DLYQD-VLCLTLFDRDQFSPDDFLGRTEIPVAKIR 477 >5UNP-A nrPDB Length = 369 Score = 46.2 bits (108), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 50/238 (21%), Positives = 92/238 (38%), Gaps = 43/238 (18%) Query: 342 FNFLMVLGKGSFGKVM--LSERKGTDELYAVKILKK-DVVIQDDDVECTMVEKRVLALPG 398 + + LG+G+FG+V+ + R+G + A+KI+K + + +E ++EK P Sbjct: 36 YEIVSTLGEGTFGRVVQCVDHRRGGARV-ALKIIKNVEKYKEAARLEINVLEKINEKDPD 94 Query: 399 KPPFLTQLHSCFQTMDRLYFVMEYV---------NGGDLMYHIQQVGRFKEPHAVFYAAE 449 Q+ F + E + + L Y I QV A + Sbjct: 95 NKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHM--------AFQ 146 Query: 450 IAIGLFFLQSKGIIYRDLKLDNVMLDSEGH-------------------IKIADFGMCKE 490 + + FL + + DLK +N++ + + +++ DFG Sbjct: 147 LCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSA-- 204 Query: 491 NIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDE 548 +D T T Y APE+I + + D W+ G +++E G F+ D E Sbjct: 205 -TFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNRE 261 >2CMW-A nrPDB Length = 310 Score = 45.1 bits (105), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 55/226 (24%), Positives = 95/226 (42%), Gaps = 40/226 (17%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 407 +G G+FG++ L + T+E A+K+ ++ R L + F QL Sbjct: 8 IGCGNFGELRLGKNLYTNEYVAIKL--------------EPIKSRAPQLHLEYRFYKQLG 53 Query: 408 SCFQTMDRLYF----------VMEYVNGGDLMYHIQQVGR-FKEPHAVFYAAEIAIGLFF 456 S + + ++Y+ V+E + G L R F + A ++ + + Sbjct: 54 SAGEGLPQVYYFGPCGKYNAMVLELL-GPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEY 112 Query: 457 LQSKGIIYRDLKLDNVMLDSEGH-----IKIADFGMCKENIWDGVTT--------KTFCG 503 + SK +IYRD+K +N ++ +G+ I I DFG+ KE I D T K+ G Sbjct: 113 VHSKNLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYI-DPETKKHIPYREHKSLTG 171 Query: 504 TPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDEL 549 T Y++ + + D A G + L G P++G D L Sbjct: 172 TARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTL 217 >3KY9-A nrPDB Length = 587 Score = 44.7 bits (104), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 19/51 (37%), Positives = 27/51 (52%), Gaps = 1/51 (1%) Query: 102 HKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCG 152 H F++ ++ T C C LL G +QG +C C + HK C+ VP CG Sbjct: 519 HDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCRASAHKECLGRVPP-CG 568 Score = 32.3 bits (72), Expect = 0.77, Method: Compositional matrix adjust. Identities = 14/42 (33%), Positives = 19/42 (45%) Query: 37 HKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRC 78 H F F++ T C C + G QG++C C HK C Sbjct: 519 HDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCRASAHKEC 560 >4PL5-B nrPDB Length = 435 Score = 44.3 bits (103), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 35/104 (33%), Positives = 56/104 (53%), Gaps = 18/104 (17%) Query: 453 GLFFLQSKGIIYRDLKLDNVML---DSEGHIK--IADFGMCKENIWDGVTTKTFC----- 502 GL L S I++RDLK N++L ++ G IK I+DFG+CK+ V +F Sbjct: 133 GLAHLHSLNIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKL---AVGRHSFSRRSGV 189 Query: 503 -GTPDYIAPEIIAYQPYGK---SVDWWAFGVLLYEMLA-GQAPF 541 GT +IAPE+++ +VD ++ G + Y +++ G PF Sbjct: 190 PGTEGWIAPEMLSEDCKDNPTYTVDIFSAGCVFYYVISEGYHPF 233 >4F9B-A nrPDB Length = 361 Score = 44.3 bits (103), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 49/233 (21%), Positives = 92/233 (39%), Gaps = 41/233 (17%) Query: 348 LGKGSFGKVMLSERK---GTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLT 404 +G+G+F V L+ + G +E KI K ++ + E + L + G + Sbjct: 29 IGEGTFSSVYLATAQLQVGPEE----KIALKHLIPTSHPIRIA-AELQCLTVAGGQDNVM 83 Query: 405 QLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIY 464 + CF+ D + M Y+ + + + F+E Y + L + GI++ Sbjct: 84 GVKYCFRKNDHVVIAMPYLEHESFLDILNSLS-FQEVRE--YMLNLFKALKRIHQFGIVH 140 Query: 465 RDLKLDNVMLDSE-GHIKIADFGM-----------------------CKENIWDGVTTKT 500 RD+K N + + + DFG+ C +N ++ Sbjct: 141 RDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNKCSICLSRR 200 Query: 501 -----FCGTPDYIAPEIIAYQP-YGKSVDWWAFGVLLYEMLAGQAPFEGEDED 547 GTP + APE++ P ++D W+ GV+ +L+G+ PF +D Sbjct: 201 QQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDD 253 >3BJI-A nrPDB Length = 378 Score = 44.3 bits (103), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 19/51 (37%), Positives = 27/51 (52%), Gaps = 1/51 (1%) Query: 102 HKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCG 152 H F++ ++ T C C LL G +QG +C C + HK C+ VP CG Sbjct: 328 HDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCRASAHKECLGRVPP-CG 377 Score = 32.0 bits (71), Expect = 0.86, Method: Compositional matrix adjust. Identities = 14/42 (33%), Positives = 19/42 (45%) Query: 37 HKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRC 78 H F F++ T C C + G QG++C C HK C Sbjct: 328 HDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCRASAHKEC 369 >6HV0-A nrPDB Length = 416 Score = 44.3 bits (103), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 34/104 (32%), Positives = 57/104 (54%), Gaps = 18/104 (17%) Query: 453 GLFFLQSKGIIYRDLKLDNVML---DSEGHIK--IADFGMCKENIWDGVTTKTFC----- 502 GL L S I++RDLK N+++ ++ G IK I+DFG+CK+ V +F Sbjct: 114 GLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKL---AVGRHSFSRRSGV 170 Query: 503 -GTPDYIAPEIIA---YQPYGKSVDWWAFGVLLYEMLA-GQAPF 541 GT +IAPE+++ + +VD ++ G + Y +++ G PF Sbjct: 171 PGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPF 214 >5VDK-A nrPDB Length = 297 Score = 43.5 bits (101), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 31/131 (23%), Positives = 60/131 (45%), Gaps = 5/131 (3%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 407 +G G FG V ++ +YA+K K ++ + E A+ G P + + + Sbjct: 23 IGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNE-NSALHEVYAHAVLGHHPHVVRYY 81 Query: 408 SCFQTMDRLYFVMEYVNGGDLMYHIQQVGR----FKEPHAVFYAAEIAIGLFFLQSKGII 463 S + D + EY NGG L I + + F+EP +I++GL ++ + ++ Sbjct: 82 SSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQISLGLNYIHNSSMV 141 Query: 464 YRDLKLDNVML 474 + D+K N+ + Sbjct: 142 HLDIKPSNIFI 152 >2VRW-B nrPDB Length = 406 Score = 42.7 bits (99), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 19/51 (37%), Positives = 26/51 (50%), Gaps = 1/51 (1%) Query: 102 HKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCG 152 H F++ ++ T C C LL G +QG +C C HK C+ VP CG Sbjct: 347 HDFQMFSFEETTSCKACQMLLRGTFYQGYRCYRCRAPAHKECLGRVPP-CG 396 Score = 31.2 bits (69), Expect = 1.7, Method: Compositional matrix adjust. Identities = 14/42 (33%), Positives = 19/42 (45%) Query: 37 HKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRC 78 H F F++ T C C + G QG++C C HK C Sbjct: 347 HDFQMFSFEETTSCKACQMLLRGTFYQGYRCYRCRAPAHKEC 388 >3MDY-A nrPDB Length = 337 Score = 42.4 bits (98), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 49/208 (23%), Positives = 96/208 (46%), Gaps = 28/208 (13%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKIL---KKDVVIQDDDVECTMVEKRVLALPGKPPFLT 404 +GKG +G+V + + +G E AVK+ ++ ++ ++ T++ + L F+ Sbjct: 45 IGKGRYGEVWMGKWRG--EKVAVKVFFTTEEASWFRETEIYQTVLMRHENILG----FIA 98 Query: 405 QLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR-FKEPHAVFYAA-----EIAIGLFFLQ 458 + +LY + +Y G L +++ K + Y++ + +F Q Sbjct: 99 ADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEIFSTQ 158 Query: 459 SK-GIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDG----VTTKTFCGTPDYIAPEII 513 K I +RDLK N+++ G IAD G+ + I D + T GT Y+ PE++ Sbjct: 159 GKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPEVL 218 Query: 514 -------AYQPYGKSVDWWAFGVLLYEM 534 +Q Y + D ++FG++L+E+ Sbjct: 219 DESLNRNHFQSYIMA-DMYSFGLILWEV 245 >1BCI-A nrPDB Length = 138 Score = 42.4 bits (98), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 22/75 (29%), Positives = 45/75 (60%), Gaps = 4/75 (5%) Query: 193 DPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSR 252 DPYV+L + P +S+++T+ +NP WNETF F L + +++ L + + D + Sbjct: 43 DPYVELFISTTP--DSRKRTRHFNNDINPVWNETFEFIL-DPNQENVLEITLMDANYV-M 98 Query: 253 NDFMGSLSFGISELQ 267 ++ +G+ +F +S ++ Sbjct: 99 DETLGTATFTVSSMK 113 >2C47-A nrPDB Length = 313 Score = 42.4 bits (98), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 36/135 (26%), Positives = 59/135 (43%), Gaps = 17/135 (12%) Query: 443 AVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEG-----HIKIADFGMCKENIWDGVT 497 + A ++ + ++ +K +IYRD+K +N ++ G I I DFG+ KE I D T Sbjct: 102 VLMIAIQLITRMEYVHTKSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYI-DPET 160 Query: 498 T--------KTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDEL 549 K+ GT Y++ + + D A G + L G P++G D L Sbjct: 161 KKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTL 220 Query: 550 ---FQSIMEHNVAYP 561 +Q I + A P Sbjct: 221 KERYQKIGDTKRATP 235 >1RLW-A nrPDB Length = 126 Score = 42.4 bits (98), Expect = 7e-04, Method: Composition-based stats. Identities = 22/75 (29%), Positives = 45/75 (60%), Gaps = 4/75 (5%) Query: 193 DPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSR 252 DPYV+L + P +S+++T+ +NP WNETF F L + +++ L + + D + Sbjct: 28 DPYVELFISTTP--DSRKRTRHFNNDINPVWNETFEFIL-DPNQENVLEITLMDANYV-M 83 Query: 253 NDFMGSLSFGISELQ 267 ++ +G+ +F +S ++ Sbjct: 84 DETLGTATFTVSSMK 98 >2Q3X-A nrPDB Length = 171 Score = 42.0 bits (97), Expect = 8e-04, Method: Composition-based stats. Identities = 27/87 (31%), Positives = 46/87 (52%), Gaps = 4/87 (4%) Query: 194 PYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRLSVEIW-DWDLTSR 252 PYVK+ L+ + +K+KT+ + +L+P + ++ F ES + + L V +W D+ Sbjct: 54 PYVKVYLLENGACIAKKKTRIARKTLDPLYQQSLVFD--ESPQGKVLQVIVWGDYGRMDH 111 Query: 253 NDFMGSLSFGISELQKAG-VDGWFKLL 278 FMG + EL + V GW+KL Sbjct: 112 KCFMGVAQILLEELDLSSMVIGWYKLF 138 >4NPK-A nrPDB Length = 299 Score = 42.0 bits (97), Expect = 0.001, Method: Compositional matrix adjust. Identities = 28/89 (31%), Positives = 50/89 (56%), Gaps = 8/89 (8%) Query: 190 GLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWDL 249 G SDPY +++ +++ IK +L+P+WNE + + E + L +E++D D Sbjct: 49 GKSDPYGIIRV-----GNQIFQSRVIKENLSPKWNEVYEALVYEH-PGQELEIELFDED- 101 Query: 250 TSRNDFMGSLSFGISELQKAG-VDGWFKL 277 ++DF+GSL + E++K +D WF L Sbjct: 102 PDKDDFLGSLMIDLIEVEKERLLDEWFTL 130 >2CHL-A nrPDB Length = 351 Score = 42.0 bits (97), Expect = 0.001, Method: Compositional matrix adjust. Identities = 39/132 (29%), Positives = 58/132 (43%), Gaps = 21/132 (15%) Query: 450 IAIGLF----FLQSKGIIYRDLKLDNVMLDSEGH-----IKIADFGMCKENIWDGVTT-- 498 IAI L ++ SK +IYRD+K +N ++ G+ I I DF + KE I D T Sbjct: 131 IAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYI-DPETKKH 189 Query: 499 ------KTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDEL--- 549 K+ GT Y++ + + D A G + L G P++G D L Sbjct: 190 IPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKER 249 Query: 550 FQSIMEHNVAYP 561 +Q I + A P Sbjct: 250 YQKIGDTKRATP 261 >4P42-A nrPDB Length = 474 Score = 41.6 bits (96), Expect = 0.001, Method: Compositional matrix adjust. Identities = 28/89 (31%), Positives = 50/89 (56%), Gaps = 8/89 (8%) Query: 190 GLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWDL 249 G SDPY +++ +++ IK +L+P+WNE + + E + L +E++D D Sbjct: 222 GKSDPYGIIRV-----GNQIFQSRVIKENLSPKWNEVYEALVYEH-PGQELEIELFDED- 274 Query: 250 TSRNDFMGSLSFGISELQKAG-VDGWFKL 277 ++DF+GSL + E++K +D WF L Sbjct: 275 PDKDDFLGSLMIDLIEVEKERLLDEWFTL 303 >5YQ3-A nrPDB Length = 162 Score = 41.6 bits (96), Expect = 0.001, Method: Compositional matrix adjust. Identities = 31/103 (30%), Positives = 50/103 (48%), Gaps = 5/103 (4%) Query: 172 VLIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNET--FRF 229 +L V + K L D G DPYV+++ + S K + NP WN+ +R Sbjct: 5 ILEVSLISGKGLKRSDFLGKIDPYVEIQYKGQTRKSSVAKEDGGR---NPTWNDKLKWRA 61 Query: 230 QLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKAGVD 272 + S D +L V++ D D S +DF+G + + EL + GV+ Sbjct: 62 EFPGSGADYKLIVKVMDHDTFSSDDFIGEATVHVKELLEMGVE 104 >1CJY-A nrPDB Length = 749 Score = 41.6 bits (96), Expect = 0.001, Method: Compositional matrix adjust. Identities = 22/75 (29%), Positives = 45/75 (60%), Gaps = 4/75 (5%) Query: 193 DPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSR 252 DPYV+L + P +S+++T+ +NP WNETF F L + +++ L + + D + Sbjct: 43 DPYVELFISTTP--DSRKRTRHFNNDINPVWNETFEFIL-DPNQENVLEITLMDANYV-M 98 Query: 253 NDFMGSLSFGISELQ 267 ++ +G+ +F +S ++ Sbjct: 99 DETLGTATFTVSSMK 113 >4RJ9-A nrPDB Length = 165 Score = 41.2 bits (95), Expect = 0.002, Method: Composition-based stats. Identities = 26/75 (34%), Positives = 40/75 (53%), Gaps = 8/75 (10%) Query: 192 SDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWDLTS 251 SDPYV +++ + K KT+ IK + NPEWN+ +++ RL E++D D T Sbjct: 27 SDPYVIVRM-----GKQKLKTRVIKKTTNPEWNDELTLSIEDPAVPVRL--EVYDKD-TF 78 Query: 252 RNDFMGSLSFGISEL 266 +D MG+ I L Sbjct: 79 IDDAMGNAELDIRPL 93 >4NT4-A nrPDB Length = 312 Score = 41.2 bits (95), Expect = 0.002, Method: Compositional matrix adjust. Identities = 37/141 (26%), Positives = 61/141 (43%), Gaps = 17/141 (12%) Query: 437 RFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVML-----DSEGHIKIADFGMCKEN 491 +F + A ++ + ++ S+ +IYRD+K +N ++ E I I DFG+ KE Sbjct: 110 KFSLKTVLMIAKQLLHRIEYVHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEY 169 Query: 492 IWDGVTT--------KTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEG 543 I D T K+ GT Y++ + + D A G + L G P++G Sbjct: 170 I-DLDTNRHIPYREHKSLTGTARYMSINTHMGREQSRRDDLEALGHMFMYFLRGSLPWQG 228 Query: 544 EDEDEL---FQSIMEHNVAYP 561 D L +Q I + A P Sbjct: 229 LKADTLKERYQKIGDTKRATP 249 >4JRN-A nrPDB Length = 372 Score = 40.8 bits (94), Expect = 0.002, Method: Compositional matrix adjust. Identities = 30/93 (32%), Positives = 45/93 (48%), Gaps = 10/93 (10%) Query: 445 FYAAEIAIGLFF-LQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCG 503 Y + AI L +Q++GI++ D+K N +L +G + + DFG + N G G Sbjct: 205 MYLSSQAIKLVANVQAQGIVHTDIKPANFLLLKDGRLFLGDFGTYRINNSVGRA----IG 260 Query: 504 TPDYIAPEIIAYQPYGKS----VDWWAFGVLLY 532 TP Y PE +Q G + D W G+ LY Sbjct: 261 TPGYEPPE-RPFQATGITYTFPTDAWQLGITLY 292 >2DB6-A nrPDB Length = 74 Score = 40.4 bits (93), Expect = 0.003, Method: Compositional matrix adjust. Identities = 22/59 (37%), Positives = 28/59 (47%), Gaps = 1/59 (1%) Query: 35 KNHKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFS-CPGADKG 92 K HKF FFK+P FC C I K G +C+ C +H+ C +V C G G Sbjct: 16 KPHKFKDHFFKKPKFCDVCARMIVLNNKFGLRCKNCKTNIHEHCQSYVEMQRCSGPSSG 74 Score = 39.7 bits (91), Expect = 0.005, Method: Compositional matrix adjust. Identities = 16/42 (38%), Positives = 23/42 (54%) Query: 102 HKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRC 143 HKFK H + P FCD C ++ G++C C N+H+ C Sbjct: 18 HKFKDHFFKKPKFCDVCARMIVLNNKFGLRCKNCKTNIHEHC 59 >4I94-A nrPDB Length = 300 Score = 40.0 bits (92), Expect = 0.003, Method: Compositional matrix adjust. Identities = 35/136 (25%), Positives = 63/136 (46%), Gaps = 8/136 (5%) Query: 406 LHSCFQTMDRLYFVMEYVNGGDLMYHI--QQVGRFKEPHAVFYAAEIAIGLFFLQSKG-I 462 L C++ +RL + E++ L H+ + K + A IA L + SKG Sbjct: 91 LGCCYEDEERL-LIAEFMPNETLAKHLFHWESQPMKWAMRLRVALHIAQALEYCTSKGRA 149 Query: 463 IYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSV 522 +Y DL V+ D + + +++ FG+ K N DG K++ + PE + Sbjct: 150 LYHDLNAYRVLFDDDANPRLSCFGLMK-NSRDG---KSYSTNLAFTPPEYLRTGRVTPES 205 Query: 523 DWWAFGVLLYEMLAGQ 538 ++FG LL ++L+G+ Sbjct: 206 VIYSFGTLLLDLLSGK 221 >5CLR-A nrPDB Length = 451 Score = 39.7 bits (91), Expect = 0.004, Method: Compositional matrix adjust. Identities = 25/77 (32%), Positives = 38/77 (49%), Gaps = 6/77 (7%) Query: 461 GIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA---YQP 517 G+I+RDLK N+MLD++ + DFG D GT Y+APE+ A + Sbjct: 196 GLIHRDLKPGNIMLDADMQCHLVDFGSSSS---DKEPKPASWGTASYLAPELNAQEDFIA 252 Query: 518 YGKSVDWWAFGVLLYEM 534 + + D +A L E+ Sbjct: 253 FSQVSDLFALAYSLDEL 269 >3G2F-A nrPDB Length = 336 Score = 38.5 bits (88), Expect = 0.010, Method: Compositional matrix adjust. Identities = 48/234 (20%), Positives = 97/234 (41%), Gaps = 51/234 (21%) Query: 337 MKLTDFNFLMVLGKGSFGKVM---LSERKGTDELYAVK-----ILKKDV----VIQDDDV 384 + L + L ++G+G +G V L ER ++++ I +K++ +++ D++ Sbjct: 10 LDLDNLKLLELIGRGRYGAVYKGSLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNI 69 Query: 385 ECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAV 444 +V + G+ +L VMEY G L ++ + + Sbjct: 70 ARFIVGDERVTADGRMEYL--------------LVMEYYPNGSLCKYLS-LHTSDWVSSC 114 Query: 445 FYAAEIAIGLFFLQSK---------GIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDG 495 A + GL +L ++ I +RDL NV++ ++G I+DFG+ + Sbjct: 115 RLAHSVTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNR 174 Query: 496 VT--------TKTFCGTPDYIAPEIIA-------YQPYGKSVDWWAFGVLLYEM 534 + + GT Y+APE++ + K VD +A G++ +E+ Sbjct: 175 LVRPGEEDNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEI 228 >5X1R-A nrPDB Length = 302 Score = 38.1 bits (87), Expect = 0.011, Method: Compositional matrix adjust. Identities = 45/242 (18%), Positives = 89/242 (36%), Gaps = 23/242 (9%) Query: 321 TANTISKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVK-ILKKDVVI 379 + I+K ++N + +F +G+G FG V + + A+K + + Sbjct: 2 SGTGITKPNSNSLPSGYRFNEFEIQEAIGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAK 61 Query: 380 QDDDVECTM-----------------VEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEY 422 ++DD+ + E R+LA P L L ++ Y ++ Sbjct: 62 RNDDLSIGLRGERFGKTFQAGLNSFIQEARLLARFSHPGLLHVLR-FWEENGTAYMGTQF 120 Query: 423 VNGGDLM-YHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIK 481 +G L QQ + E + + + +G ++RD+ LDN+ + Sbjct: 121 YSGTTLKNLQAQQPEKIDEAWIRRLLPPLFSAINTIHQEGYLHRDISLDNIQIQESQLPV 180 Query: 482 IADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDW---WAFGVLLYEMLAGQ 538 + DFG ++ I + P + E G+ W +A G +L+ ++ G Sbjct: 181 LLDFGSARKEIGNLSDETEIVLKPGFAPIEQYTENSDGEQGPWTDIYALGAVLHTLIVGS 240 Query: 539 AP 540 P Sbjct: 241 PP 242 >1PY5-A nrPDB Length = 326 Score = 37.7 bits (86), Expect = 0.017, Method: Compositional matrix adjust. Identities = 55/224 (24%), Positives = 93/224 (41%), Gaps = 35/224 (15%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDV---ECTMVEKRVLALPGKPPFLT 404 +GKG FG+V + +G E AVKI +++ E + + +L F+ Sbjct: 37 IGKGRFGEVWRGKWRG--EEVAVKIFSS----REERSWFREAEIYQTVMLRHENILGFIA 90 Query: 405 QLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSK---- 460 + T +L+ V +Y G L ++ + E + A A GL L + Sbjct: 91 ADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEG-MIKLALSTASGLAHLHMEIVGT 149 Query: 461 ----GIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKT------FCGTPDYIAP 510 I +RDLK N+++ G IAD G+ + D T GT Y+AP Sbjct: 150 QGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRH--DSATDTIDIAPNHRVGTKRYMAP 207 Query: 511 EII-------AYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDED 547 E++ ++ + K D +A G++ +E +A + G ED Sbjct: 208 EVLDDSINMKHFESF-KRADIYAMGLVFWE-IARRCSIGGIHED 249 >3SV0-A nrPDB Length = 483 Score = 37.4 bits (85), Expect = 0.019, Method: Compositional matrix adjust. Identities = 58/255 (22%), Positives = 99/255 (38%), Gaps = 34/255 (13%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVL----ALP 397 F +G GSFG++ L T+E A+K+ ++V + + R+L +P Sbjct: 9 FRLGRKIGSGSFGEIYLGTNIQTNEEVAIKL--ENVKTKHPQLLYESKIYRILQGGTGIP 66 Query: 398 GKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFL 457 F + MD L +E DL + K + A ++ + F+ Sbjct: 67 NVRWFGVEGDYNVLVMDLLGPSLE-----DLFNFCSRKLSLKT--VLMLADQMINRVEFV 119 Query: 458 QSKGIIYRDLKLDNVMLD---SEGHIKIADFGMCKENIWDGVT--------TKTFCGTPD 506 SK ++RD+K DN ++ + I DFG+ K+ D T K GT Sbjct: 120 HSKSFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKK-YRDTSTHQHIPYRENKNLTGTAR 178 Query: 507 YIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEG---EDEDELFQSIMEHNVAYPKS 563 Y + + D + G +L L G P++G + + ++ I E VA Sbjct: 179 YASVNTHLGIEQSRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKYEKISEKKVA---- 234 Query: 564 MSKEAVAICKGLMTK 578 A+C+G T+ Sbjct: 235 --TSIEALCRGYPTE 247 >5X18-A nrPDB Length = 295 Score = 36.6 bits (83), Expect = 0.037, Method: Compositional matrix adjust. Identities = 28/100 (28%), Positives = 45/100 (45%), Gaps = 14/100 (14%) Query: 457 LQSKGIIYRDLKLDNVMLDSEG-----HIKIADFGMCKENIWDGVT--------TKTFCG 503 L + +IYRD+K DN ++ G +I + DFGM K+ D T K+ G Sbjct: 119 LHAHDLIYRDIKPDNFLIGRPGQPDANNIHLIDFGMAKQ-YRDPKTKQHIPYREKKSLSG 177 Query: 504 TPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEG 543 T Y++ + + D A G + + L G P++G Sbjct: 178 TARYMSINTHLGREQSRRDDMEALGHVFFYFLRGHLPWQG 217 >6G4J-A nrPDB Length = 315 Score = 35.8 bits (81), Expect = 0.067, Method: Compositional matrix adjust. Identities = 41/149 (27%), Positives = 62/149 (41%), Gaps = 23/149 (15%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 407 LGKG+ G V L+E +D A+K+ DD E VL K +T Sbjct: 34 LGKGANGIVYLAET--SDGHVALKV--------SDDSLSITSEVNVLKSFSKAQSVTMGP 83 Query: 408 SCFQTMDRL---------YFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQ 458 S F T D ++ MEY+ G L+ ++ G P + ++ L L Sbjct: 84 SFFDTDDAYIPSANTKVSFYAMEYIKGPLLLKYVSDKGAEWIPVLMI---QLLSSLSVLH 140 Query: 459 SKGIIYRDLKLDNVMLDS-EGHIKIADFG 486 +G I+ DLK DN+++ I+ D G Sbjct: 141 QQGWIFGDLKPDNLIVTGPPARIRCIDVG 169 >6G18-v nrPDB Length = 552 Score = 34.7 bits (78), Expect = 0.12, Method: Compositional matrix adjust. Identities = 23/73 (31%), Positives = 39/73 (53%), Gaps = 8/73 (10%) Query: 414 DRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVF-YAAEIAIGLFFLQSKGIIYRDLKLDNV 472 +R VME +NG Y + Q+ ++P +V+ A E+ + L + G+I+ D N+ Sbjct: 182 NRHAVVMELING----YPLCQIHHVEDPASVYDEAMELIVKL---ANHGLIHGDFNEFNL 234 Query: 473 MLDSEGHIKIADF 485 +LD HI + DF Sbjct: 235 ILDESDHITMIDF 247 >1CSN-A nrPDB Length = 298 Score = 34.7 bits (78), Expect = 0.15, Method: Compositional matrix adjust. Identities = 27/100 (27%), Positives = 42/100 (42%), Gaps = 14/100 (14%) Query: 457 LQSKGIIYRDLKLDNVML-----DSEGHIKIADFGMCKENIWDGVT--------TKTFCG 503 + K ++YRD+K DN ++ + I + DFGM K D VT K G Sbjct: 122 IHEKSLVYRDIKPDNFLIGRPNSKNANMIYVVDFGMVKF-YRDPVTKQHIPYREKKNLSG 180 Query: 504 TPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEG 543 T Y++ + + D A G + L G P++G Sbjct: 181 TARYMSINTHLGREQSRRDDLEALGHVFMYFLRGSLPWQG 220 >3SOC-A nrPDB Length = 322 Score = 34.7 bits (78), Expect = 0.15, Method: Compositional matrix adjust. Identities = 27/81 (33%), Positives = 41/81 (50%), Gaps = 7/81 (8%) Query: 461 GIIYRDLKLDNVMLDSEGHIKIADFGMCK--ENIWDGVTTKTFCGTPDYIAPEI----IA 514 I +RD+K NV+L + IADFG+ E T GT Y+APE+ I Sbjct: 151 AISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAIN 210 Query: 515 YQPYG-KSVDWWAFGVLLYEM 534 +Q +D +A G++L+E+ Sbjct: 211 FQRDAFLRIDMYAMGLVLWEL 231 >2QLU-A nrPDB Length = 314 Score = 34.7 bits (78), Expect = 0.15, Method: Compositional matrix adjust. Identities = 38/134 (28%), Positives = 59/134 (44%), Gaps = 15/134 (11%) Query: 462 IIYRDLKLDNVMLDSEGHIKIADFGMCK--ENIWDGVTTKTFCGTPDYIAPEI----IAY 515 I +RD K NV+L S+ +ADFG+ E T GT Y+APE+ I + Sbjct: 144 IAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVGTRRYMAPEVLEGAINF 203 Query: 516 QPYG-KSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKG 574 Q +D +A G++L+E+++ +G DE E +P + V + K Sbjct: 204 QRDAFLRIDMYAMGLVLWELVSRCKAADG-PVDEYMLPFEEEIGQHPSLEELQEVVVHKK 262 Query: 575 L-------MTKHPG 581 + KHPG Sbjct: 263 MRPTIKDHWLKHPG 276 >5CDF-E nrPDB Length = 474 Score = 34.3 bits (77), Expect = 0.16, Method: Compositional matrix adjust. Identities = 25/87 (28%), Positives = 39/87 (44%), Gaps = 19/87 (21%) Query: 517 PYGKSVDWWAFG-------VLLYEML-------AGQAPFEGEDE-----DELFQSIMEHN 557 PY K FG VL+ E++ +G + F G E ++L+ ++E Sbjct: 140 PYSKGGKIGLFGGAGVGKTVLIMELINNIAKVHSGYSVFAGVGERTREGNDLYHEMVESG 199 Query: 558 VAYPKSMSKEAVAICKGLMTKHPGKRL 584 V P +SK VA+ G M + PG R+ Sbjct: 200 VIKPDDLSKSQVALVYGQMNEPPGARM 226 >5E8V-A nrPDB Length = 316 Score = 34.3 bits (77), Expect = 0.18, Method: Compositional matrix adjust. Identities = 22/83 (26%), Positives = 42/83 (50%), Gaps = 10/83 (12%) Query: 462 IIYRDLKLDNVMLDSEGHIKIADFGMCKE----NIWDGVTTKTFCGTPDYIAPEIIAYQP 517 I++RDLK N+++ ++ + DFG+ D + GT Y+APE++A Sbjct: 142 IVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLASAM 201 Query: 518 YGKSV------DWWAFGVLLYEM 534 ++V D ++ ++L+EM Sbjct: 202 NLENVESFKQTDVYSMALVLWEM 224 >4TN6-A nrPDB Length = 318 Score = 34.3 bits (77), Expect = 0.20, Method: Compositional matrix adjust. Identities = 58/250 (23%), Positives = 94/250 (37%), Gaps = 44/250 (17%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQ-- 405 +G GSFG + L E A+K+ EC + L + K + Q Sbjct: 15 IGSGSFGDIYLGTDIAAGEEVAIKL------------ECVKTKHPQLHIESKIYKMMQGG 62 Query: 406 -----LHSCFQTMDRLYFVMEYVNGG--DLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQ 458 + C D VME + DL + +F + A ++ + ++ Sbjct: 63 VGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSR--KFSLKTVLLLADQMISRIEYIH 120 Query: 459 SKGIIYRDLKLDNVM--LDSEGH-IKIADFGMCKENIWDGVT--------TKTFCGTPDY 507 SK I+RD+K DN + L +G+ + I DFG+ K+ D T K GT Y Sbjct: 121 SKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKK-YRDARTHQHIPYRENKNLTGTARY 179 Query: 508 IAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEG---EDEDELFQSIMEHNVAYPKSM 564 + + D + G +L G P++G + + ++ I E K M Sbjct: 180 ASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISE------KKM 233 Query: 565 SKEAVAICKG 574 S +CKG Sbjct: 234 STPIEVLCKG 243 >6EWX-A nrPDB Length = 484 Score = 33.9 bits (76), Expect = 0.26, Method: Compositional matrix adjust. Identities = 36/144 (25%), Positives = 55/144 (38%), Gaps = 43/144 (29%) Query: 440 EPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVML------------------------- 474 E F ++ GL L+ GII+RDL L+N++L Sbjct: 209 ERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLVHCNPQSSPGPSANPSVPTTTSRCP 268 Query: 475 -------------DSEGHIK---IADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY 518 E H+ I++F K+ G T + +APEI++ Y Sbjct: 269 SAAPAATTACQGGPGEKHLPRLIISNFLKAKQKP-GGTTNLQQKKSQARLAPEIVSASQY 327 Query: 519 GKSVDWWAFGVLLYEMLAGQAPFE 542 K D + G+L+YE+L PFE Sbjct: 328 RK-FDEFQTGILIYELLHQPNPFE 350 >2DMH-A nrPDB Length = 140 Score = 33.5 bits (75), Expect = 0.29, Method: Composition-based stats. Identities = 28/97 (28%), Positives = 46/97 (47%), Gaps = 8/97 (8%) Query: 172 VLIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQL 231 +L V+V A N +P G DP V + + K+KTK + LNP WNE F L Sbjct: 8 MLRVIVESASN-IPKTKFGKPDPIVSVIF-----KDEKKKTKKVDNELNPVWNEILEFDL 61 Query: 232 K--ESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISEL 266 + D L + + D++ +N +G+ + + +L Sbjct: 62 RGIPLDFSSSLGIIVKDFETIGQNKLIGTATVALKDL 98 >1DJX-A nrPDB Length = 624 Score = 33.5 bits (75), Expect = 0.29, Method: Compositional matrix adjust. Identities = 24/88 (27%), Positives = 44/88 (50%), Gaps = 4/88 (4%) Query: 184 VPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCS-LNPEWNETFRFQLKESDKDR-RLS 241 V + N + DP V +++ + ++T I + NP W+ F F++ D R Sbjct: 512 VNKNKNSIVDPKVIVEIHGVGRDTGSRQTAVITNNGFNPRWDMEFEFEVTVPDLALVRFM 571 Query: 242 VEIWDWDLTSRNDFMGSLSFGISELQKA 269 VE D+D +S+NDF+G + + L++ Sbjct: 572 VE--DYDSSSKNDFIGQSTIPWNSLKQG 597 >2W1Z-A nrPDB Length = 368 Score = 33.5 bits (75), Expect = 0.30, Method: Compositional matrix adjust. Identities = 20/93 (21%), Positives = 43/93 (46%), Gaps = 12/93 (12%) Query: 457 LQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGT----PDYIAPEI 512 LQ G+++ D ++ N++LD G + + F + + DG + + G P+ A + Sbjct: 207 LQHYGLVHADFQVRNILLDQRGGVFLTGF---EHLVRDGASAVSPIGRGFAPPETTAERM 263 Query: 513 IAYQPYGKSV-----DWWAFGVLLYEMLAGQAP 540 + Y+ + ++ D W G+ +Y + P Sbjct: 264 LPYRQHHPTLMTFPFDTWTLGLAIYWIWCADLP 296 >6FDN-A nrPDB Length = 320 Score = 33.5 bits (75), Expect = 0.31, Method: Compositional matrix adjust. Identities = 23/73 (31%), Positives = 39/73 (53%), Gaps = 8/73 (10%) Query: 414 DRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVF-YAAEIAIGLFFLQSKGIIYRDLKLDNV 472 +R VME +NG Y + Q+ ++P +V+ A E+ + L + G+I+ D N+ Sbjct: 182 NRHAVVMELING----YPLCQIHHVEDPASVYDEAMELIVKL---ANHGLIHGDFNEFNL 234 Query: 473 MLDSEGHIKIADF 485 +LD HI + DF Sbjct: 235 ILDESDHITMIDF 247 >4NFN-A nrPDB Length = 309 Score = 33.1 bits (74), Expect = 0.38, Method: Compositional matrix adjust. Identities = 52/234 (22%), Positives = 93/234 (39%), Gaps = 23/234 (9%) Query: 334 RDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRV 393 +DR K+ L +G G FG++ + T E A+K+ Q +E +++K Sbjct: 20 KDRWKV-----LKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVLKMEVAVLKK-- 72 Query: 394 LALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDL--MYHIQQVGRFKEPHAVFYAAEIA 451 L GK + + C + Y VM+ + G +L + Q G F + +I Sbjct: 73 --LQGKD-HVCRFIGCGRNEKFNYVVMQ-LQGRNLADLRRSQPRGTFTLSTTLRLGKQIL 128 Query: 452 IGLFFLQSKGIIYRDLKLDNVML----DSEGHIKIADFGMCKE------NIWDGVTTKTF 501 + + S G ++RD+K N + + + DFG+ ++ ++ F Sbjct: 129 ESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGF 188 Query: 502 CGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIME 555 GT Y + + G+ D W+ +L E GQ P+ + E I E Sbjct: 189 RGTVRYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKE 242 >4BTK-A nrPDB Length = 337 Score = 33.1 bits (74), Expect = 0.41, Method: Compositional matrix adjust. Identities = 54/234 (23%), Positives = 93/234 (39%), Gaps = 23/234 (9%) Query: 334 RDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRV 393 +DR K+ L +G G FG++ + T E A+K+ Q +E +++K Sbjct: 55 KDRWKV-----LKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVLKMEVAVLKK-- 107 Query: 394 LALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDL--MYHIQQVGRFKEPHAVFYAAEIA 451 L GK + + C + Y VM+ + G +L + Q G F + +I Sbjct: 108 --LQGKD-HVCRFIGCGRNEKFNYVVMQ-LQGRNLADLRRSQPRGTFTLSTTLRLGKQIL 163 Query: 452 IGLFFLQSKGIIYRDLKLDNVML----DSEGHIKIADFGMCKE--NIWDGV----TTKTF 501 + + S G ++RD+K N + + + DFG+ ++ N V F Sbjct: 164 ESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGF 223 Query: 502 CGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIME 555 GT Y + + G+ D W+ +L E GQ P+ + E I E Sbjct: 224 RGTVRYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKE 277 >4XHL-A nrPDB Length = 394 Score = 32.7 bits (73), Expect = 0.46, Method: Compositional matrix adjust. Identities = 31/152 (20%), Positives = 60/152 (39%), Gaps = 19/152 (12%) Query: 437 RFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLD---SEGHIKIADFGMCKE--- 490 RF + A ++ + ++ + I+RD+K DN ++ + + DFG+ K+ Sbjct: 99 RFSFKTVIMLALQMFCRIQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRD 158 Query: 491 -NIWDGV---TTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEG--- 543 N + K+ GT Y + + D + G +L G P++G Sbjct: 159 FNTHRHIPYRENKSLTGTARYASVNTHLGIEQSRRDDLESLGYVLIYFCKGSLPWQGLKA 218 Query: 544 EDEDELFQSIMEHNVAYPKSMSKEAVAICKGL 575 + + + IME K ++ +C GL Sbjct: 219 TTKKQKYDRIME------KKLNVSVETLCSGL 244 >5J0A-A nrPDB Length = 300 Score = 32.0 bits (71), Expect = 0.81, Method: Compositional matrix adjust. Identities = 40/138 (28%), Positives = 60/138 (43%), Gaps = 15/138 (10%) Query: 416 LYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEI-------AIGLFFL-QSKGIIYRDL 467 L MEY GG+ + R+K F AA I A GL +L Q K +++ D+ Sbjct: 90 LCLAMEY--GGEKSLNDLIEERYKASQDPFPAAIILKVALNMARGLKYLHQEKKLLHGDI 147 Query: 468 KLDNVMLDSEGH-IKIADFGMC---KENIWDGVTTKTFCGTPDYIAPEIIAYQ-PYGKSV 522 K NV++ + IKI D G+ EN+ + GT + E + Sbjct: 148 KSSNVVIKGDFETIKICDVGVSLPLDENMEVTDPEACYIGTEPWKPKEAVEENGVITDKA 207 Query: 523 DWWAFGVLLYEMLAGQAP 540 D +AFG+ L+EM+ P Sbjct: 208 DIFAFGLTLWEMMTLSIP 225 >4MWI-A nrPDB Length = 294 Score = 32.0 bits (71), Expect = 0.82, Method: Compositional matrix adjust. Identities = 32/141 (22%), Positives = 62/141 (43%), Gaps = 10/141 (7%) Query: 418 FVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGI--IYRDLKLDNVMLD 475 VMEY G L + + + A GL+ L ++ ++ N ++ Sbjct: 104 IVMEYCELGTLRELLDREKDLTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVT 163 Query: 476 SEGHIKIADFGMCKENIWDGVTT---KT-FCGTPDYIAP---EIIAYQPYGKSVDWWAFG 528 +K+A F + K + T KT + Y++P E + YQ Y + ++FG Sbjct: 164 QGYQVKLAGFELRKTQTSMSLGTTREKTDRVKSTAYLSPQELEDVFYQ-YDVKSEIYSFG 222 Query: 529 VLLYEMLAGQAPFEGEDEDEL 549 ++L+E+ G PF+G + +++ Sbjct: 223 IVLWEIATGDIPFQGCNSEKI 243 >5USZ-A nrPDB Length = 289 Score = 32.0 bits (71), Expect = 0.86, Method: Compositional matrix adjust. Identities = 51/265 (19%), Positives = 100/265 (37%), Gaps = 25/265 (9%) Query: 336 RMKLTDFNFLMVLGKGSFGKVMLSERKGTD---ELYAVKILKKDVVIQDDDVECTMVEKR 392 +++ D F LG+G+F K+ R+ +L+ ++L K + + + E Sbjct: 4 KIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAA 63 Query: 393 VLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFY----AA 448 + L + D V E+V G L +++ + K + + A Sbjct: 64 SMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLK---KNKNCINILWKLEVAK 120 Query: 449 EIAIGLFFLQSKGIIYRDLKLDNVMLDSEGH--------IKIADFGMCKENIWDGVTTKT 500 ++A + FL+ +I+ ++ N++L E IK++D G+ + + + Sbjct: 121 QLAAAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQER 180 Query: 501 FCGTPDYIAPEIIAY-QPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIMEHNV 558 ++ PE I + + D W+FG L+E+ + G P D Q E Sbjct: 181 I----PWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQ-FYEDRH 235 Query: 559 AYPKSMSKEAVAICKGLMTKHPGKR 583 P + E + M P R Sbjct: 236 QLPAPKAAELANLINNCMDYEPDHR 260 >4AZW-A nrPDB Length = 471 Score = 32.0 bits (71), Expect = 0.96, Method: Compositional matrix adjust. Identities = 17/49 (34%), Positives = 25/49 (51%), Gaps = 7/49 (14%) Query: 457 LQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTP 505 L+ KG + D++ NVM+D+ H ++ DFG VTT C P Sbjct: 355 LEKKGFWHDDVRPWNVMVDARQHARLIDFGSI-------VTTPQDCSWP 396 >4AZV-A nrPDB Length = 569 Score = 30.8 bits (68), Expect = 1.8, Method: Compositional matrix adjust. Identities = 24/92 (26%), Positives = 41/92 (44%), Gaps = 16/92 (17%) Query: 417 YFVMEYVNG---GDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVM 473 + VME + G D++ +++ R K + L L+ +G + D++ NVM Sbjct: 318 WLVMEKLPGRLLSDMLAAGEEIDREK------ILGSLLRSLAALEKQGFWHDDVRPWNVM 371 Query: 474 LDSEGHIKIADFGMCKENIWDGVTTKTFCGTP 505 +D+ H ++ DFG VTT C P Sbjct: 372 VDARQHARLIDFGSI-------VTTPQDCSWP 396 >6BHC-A nrPDB Length = 438 Score = 30.8 bits (68), Expect = 2.2, Method: Compositional matrix adjust. Identities = 17/39 (43%), Positives = 22/39 (56%), Gaps = 1/39 (2%) Query: 508 IAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDE 546 +APEII Y K D + G+L+YEML PF+ E Sbjct: 264 LAPEIITATQY-KKCDEFQTGILIYEMLHLPNPFDENPE 301 >5VE6-A nrPDB Length = 492 Score = 30.0 bits (66), Expect = 3.4, Method: Compositional matrix adjust. Identities = 18/48 (37%), Positives = 26/48 (54%), Gaps = 9/48 (18%) Query: 503 GTPDY--------IAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFE 542 GTP+ +APEI++ Y K D + G+L+YE+L PFE Sbjct: 312 GTPNLQQKKSQARLAPEIVSASQYRK-FDEFQTGILIYELLHQPNPFE 358 Score = 30.0 bits (66), Expect = 3.4, Method: Compositional matrix adjust. Identities = 14/35 (40%), Positives = 21/35 (60%) Query: 440 EPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVML 474 E F ++ GL L+ GII+RDL L+N++L Sbjct: 207 ERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLL 241 >5FQD-C nrPDB Length = 341 Score = 29.6 bits (65), Expect = 4.8, Method: Compositional matrix adjust. Identities = 34/153 (22%), Positives = 60/153 (39%), Gaps = 21/153 (13%) Query: 437 RFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGH---IKIADFGMCKENIW 493 RF + A ++ + ++ +K I+RD+K DN ++ H + + DFG+ K+ Sbjct: 111 RFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKK-YR 169 Query: 494 DGVTT--------KTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEG-- 543 D T K GT Y + + D + G +L P++G Sbjct: 170 DNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLK 229 Query: 544 -EDEDELFQSIMEHNVAYPKSMSKEAVAICKGL 575 + + ++ I E K MS +CKG Sbjct: 230 AATKKQKYEKISE------KKMSTPVEVLCKGF 256 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 3PFQ-A nrPDB 1016 0.0 2I0E-A nrPDB 499 e-141 4RA4-A nrPDB 487 e-138 3TXO-A nrPDB 428 e-120 5F9E-A nrPDB 416 e-116 5KCV-A nrPDB 414 e-116 2JDO-A nrPDB 413 e-115 3A8W-A nrPDB 408 e-114 3MV5-A nrPDB 404 e-113 4L42-A nrPDB 398 e-111 3HDN-A nrPDB 385 e-107 4OTD-A nrPDB 376 e-104 4CRS-A nrPDB 375 e-104 5D9K-A nrPDB 370 e-102 5X3F-B nrPDB 365 e-101 5N23-A nrPDB 365 e-101 4WB7-A nrPDB 362 e-100 2Z7Q-A nrPDB 361 e-100 1VZO-A nrPDB 358 4e-99 1FOT-A nrPDB 353 2e-97 4RLP-A nrPDB 352 2e-97 4AW2-A nrPDB 346 1e-95 6E9W-A nrPDB 342 3e-94 3TKU-A nrPDB 341 6e-94 6ED6-A nrPDB 340 2e-93 6BDL-A nrPDB 339 2e-93 5LOH-A nrPDB 325 4e-89 5FET-A nrPDB 317 1e-86 4TNB-A nrPDB 314 7e-86 3NYO-A nrPDB 313 2e-85 5UUU-A nrPDB 311 7e-85 5DYK-A nrPDB 311 9e-85 3PVW-A nrPDB 310 1e-84 4LQP-A nrPDB 307 1e-83 3ORZ-A nrPDB 306 2e-83 4C0T-A nrPDB 306 3e-83 2VD5-A nrPDB 306 3e-83 2QNJ-A nrPDB 302 3e-82 3C51-A nrPDB 302 4e-82 5KZ7-A nrPDB 301 5e-82 5ES1-A nrPDB 298 4e-81 4REW-A nrPDB 297 1e-80 3MN3-A nrPDB 296 2e-80 4CFF-A nrPDB 296 3e-80 4D28-A nrPDB 295 3e-80 4CFH-A nrPDB 295 5e-80 4RED-A nrPDB 295 5e-80 6BXI-A nrPDB 294 6e-80 5EZV-A nrPDB 294 6e-80 4YHJ-A nrPDB 294 7e-80 5JN2-A nrPDB 293 2e-79 3D2K-A nrPDB 293 2e-79 4JXF-A nrPDB 293 2e-79 5FG8-A nrPDB 293 2e-79 2YZA-A nrPDB 291 5e-79 4CZT-A nrPDB 291 7e-79 2VN9-A nrPDB 289 2e-78 4FG9-A nrPDB 289 2e-78 2JC6-A nrPDB 288 4e-78 3H4J-B nrPDB 288 4e-78 3MA6-A nrPDB 288 8e-78 2BDW-A nrPDB 288 8e-78 4MVF-A nrPDB 287 1e-77 4UZD-A nrPDB 287 1e-77 2VZ6-A nrPDB 286 2e-77 2V7O-A nrPDB 286 2e-77 5U6Y-A nrPDB 286 2e-77 3DXN-A nrPDB 286 3e-77 3HZT-A nrPDB 285 4e-77 3BHH-A nrPDB 284 8e-77 4YZB-A nrPDB 284 1e-76 2JAM-A nrPDB 283 1e-76 2HAK-A nrPDB 282 4e-76 3KK8-A nrPDB 281 5e-76 3NCG-A nrPDB 281 5e-76 3SOA-A nrPDB 281 6e-76 3LIJ-A nrPDB 281 7e-76 4CQG-A nrPDB 281 1e-75 5IG1-A nrPDB 280 1e-75 4RGJ-A nrPDB 280 1e-75 4FR4-A nrPDB 279 2e-75 5YKS-A nrPDB 279 2e-75 3DFA-A nrPDB 279 3e-75 6C9D-A nrPDB 279 3e-75 2W4O-A nrPDB 278 6e-75 4YNZ-A nrPDB 277 9e-75 4JG6-A nrPDB 277 1e-74 4I6B-A nrPDB 277 1e-74 4D2V-A nrPDB 276 2e-74 5WAX-A nrPDB 276 3e-74 4NIF-A nrPDB 272 3e-73 4B6L-A nrPDB 272 3e-73 2J90-A nrPDB 271 7e-73 4CSV-A nrPDB 271 1e-72 3UC3-A nrPDB 271 1e-72 2OU7-A nrPDB 271 1e-72 4B8L-A nrPDB 270 1e-72 2A27-A nrPDB 270 2e-72 4J52-A nrPDB 269 2e-72 2YAB-A nrPDB 269 3e-72 3DB8-A nrPDB 269 4e-72 3I6U-A nrPDB 269 4e-72 3UDB-A nrPDB 268 4e-72 3ZUT-A nrPDB 268 5e-72 3F3Z-A nrPDB 267 8e-72 1ZWS-A nrPDB 267 9e-72 4AF3-A nrPDB 267 1e-71 3COM-A nrPDB 267 2e-71 2Y7J-A nrPDB 266 2e-71 5XZW-A nrPDB 265 4e-71 3TAC-A nrPDB 265 4e-71 3Q5I-A nrPDB 265 5e-71 1PHK-A nrPDB 264 7e-71 3KN6-A nrPDB 263 2e-70 4XEY-B nrPDB 262 3e-70 4LG4-A nrPDB 262 4e-70 2BPM-A nrPDB 261 7e-70 2FO0-A nrPDB 261 8e-70 2F57-A nrPDB 261 8e-70 3GUB-A nrPDB 261 9e-70 6FDY-U nrPDB 260 1e-69 6AO5-A nrPDB 260 2e-69 5JZN-A nrPDB 259 3e-69 2YCR-A nrPDB 259 4e-69 2XYN-A nrPDB 257 9e-69 6NPU-A nrPDB 257 1e-68 6FD3-A nrPDB 256 2e-68 4PDS-A nrPDB 256 3e-68 6CMJ-A nrPDB 256 3e-68 4FIE-A nrPDB 255 5e-68 3LM0-A nrPDB 255 6e-68 4QMW-A nrPDB 254 7e-68 2Q0N-A nrPDB 254 9e-68 4XBR-A nrPDB 254 9e-68 4JDH-A nrPDB 254 1e-67 4KS7-A nrPDB 254 1e-67 6GU6-A nrPDB 253 1e-67 5A46-A nrPDB 252 2e-67 3TT0-A nrPDB 251 7e-67 4AGU-A nrPDB 251 8e-67 3NIZ-A nrPDB 250 1e-66 3Q53-A nrPDB 250 1e-66 3GQL-A nrPDB 249 2e-66 2XIK-A nrPDB 249 3e-66 2UV2-A nrPDB 249 3e-66 3PPZ-A nrPDB 249 4e-66 5D7A-A nrPDB 248 6e-66 6HXF-B nrPDB 248 7e-66 5YV8-A nrPDB 247 8e-66 4FZF-B nrPDB 247 9e-66 1KOB-A nrPDB 247 9e-66 5J5T-A nrPDB 247 1e-65 4XCU-A nrPDB 247 1e-65 4WNO-A nrPDB 246 2e-65 1AD5-A nrPDB 246 3e-65 3UTO-A nrPDB 245 4e-65 1K9A-A nrPDB 245 5e-65 4APC-A nrPDB 245 6e-65 3IS5-A nrPDB 244 9e-65 2X4F-A nrPDB 244 1e-64 2PSQ-A nrPDB 244 1e-64 1KOA-A nrPDB 243 2e-64 4KRC-A nrPDB 242 3e-64 5UE8-A nrPDB 241 6e-64 4K33-A nrPDB 241 9e-64 3FXW-A nrPDB 241 1e-63 4BBM-A nrPDB 241 1e-63 2HW6-A nrPDB 241 1e-63 2H8H-A nrPDB 240 1e-63 3V5Q-A nrPDB 240 2e-63 6F3F-A nrPDB 240 2e-63 6GQK-A nrPDB 239 2e-63 6QAU-A nrPDB 239 3e-63 1FVR-A nrPDB 239 3e-63 4AT3-A nrPDB 238 6e-63 4U41-A nrPDB 237 1e-62 5EG3-A nrPDB 237 1e-62 2HK5-A nrPDB 237 1e-62 3OZ6-A nrPDB 237 2e-62 4UY9-A nrPDB 237 2e-62 4AN9-A nrPDB 237 2e-62 2DQ7-X nrPDB 236 2e-62 3DAK-A nrPDB 236 2e-62 3A4O-X nrPDB 236 2e-62 6CKI-A nrPDB 236 3e-62 2XNP-A nrPDB 236 3e-62 2WQN-A nrPDB 236 4e-62 4E93-A nrPDB 235 4e-62 2Y6O-A nrPDB 235 4e-62 1NY3-A nrPDB 235 5e-62 5KMM-A nrPDB 235 5e-62 2PL0-A nrPDB 235 5e-62 3QGY-A nrPDB 235 6e-62 2OZA-A nrPDB 234 8e-62 4P5Q-A nrPDB 234 1e-61 4XI2-A nrPDB 234 1e-61 5SYS-A nrPDB 234 1e-61 3KA0-A nrPDB 233 1e-61 6E2O-A nrPDB 233 2e-61 3DKO-A nrPDB 233 2e-61 6E4F-A nrPDB 233 2e-61 3ZDU-A nrPDB 233 2e-61 1BYG-A nrPDB 233 2e-61 1JPA-A nrPDB 233 2e-61 2OGV-A nrPDB 232 3e-61 4Y93-A nrPDB 232 3e-61 4XUF-A nrPDB 232 3e-61 2J0K-A nrPDB 232 3e-61 3DTC-A nrPDB 232 3e-61 3SXS-A nrPDB 232 3e-61 5MJB-A nrPDB 232 4e-61 5H2U-A nrPDB 232 4e-61 3BEA-A nrPDB 232 4e-61 6DTL-A nrPDB 232 4e-61 4BGQ-A nrPDB 232 5e-61 4QNY-A nrPDB 232 5e-61 4EBW-A nrPDB 231 6e-61 2R2P-A nrPDB 231 6e-61 5X02-A nrPDB 231 6e-61 1V0B-A nrPDB 231 7e-61 1CM8-A nrPDB 231 7e-61 4AU8-A nrPDB 231 8e-61 3KRL-A nrPDB 230 1e-60 4IC8-A nrPDB 230 1e-60 4ZSG-A nrPDB 230 2e-60 1G3N-A nrPDB 229 3e-60 6CQF-A nrPDB 229 3e-60 2VWV-A nrPDB 229 3e-60 4PDO-A nrPDB 229 4e-60 5Z33-A nrPDB 229 4e-60 3G0E-A nrPDB 229 5e-60 5X5O-A nrPDB 228 5e-60 5AMN-A nrPDB 228 6e-60 2F9G-A nrPDB 228 6e-60 5GRN-A nrPDB 228 7e-60 5G6V-A nrPDB 228 7e-60 4R7H-A nrPDB 228 7e-60 4EWQ-A nrPDB 227 9e-60 6CCF-A nrPDB 227 9e-60 3HKO-A nrPDB 227 1e-59 4UYA-A nrPDB 227 1e-59 3CJF-A nrPDB 227 2e-59 4XLV-A nrPDB 227 2e-59 3HMP-A nrPDB 226 3e-59 5L6P-A nrPDB 225 6e-59 1LUF-A nrPDB 224 8e-59 3OHT-A nrPDB 224 8e-59 2BRG-A nrPDB 224 9e-59 5FM2-A nrPDB 224 1e-58 5KKR-C nrPDB 224 1e-58 1UA2-A nrPDB 224 1e-58 2ZMD-A nrPDB 224 1e-58 5VO2-A nrPDB 223 2e-58 3MIA-A nrPDB 222 3e-58 4HZS-A nrPDB 222 3e-58 3ZBF-A nrPDB 222 4e-58 3GC0-A nrPDB 222 4e-58 5DBX-A nrPDB 222 4e-58 4O2Z-A nrPDB 222 4e-58 3VN9-A nrPDB 222 5e-58 4H1J-A nrPDB 222 5e-58 1U54-B nrPDB 222 5e-58 4GS6-A nrPDB 221 6e-58 3KUL-B nrPDB 221 8e-58 3I81-A nrPDB 220 1e-57 3ORP-A nrPDB 220 1e-57 3EQC-A nrPDB 220 2e-57 5NGU-A nrPDB 220 2e-57 6FEX-A nrPDB 220 2e-57 4QTB-A nrPDB 219 3e-57 4NST-A nrPDB 219 3e-57 5EFQ-A nrPDB 219 3e-57 3FME-A nrPDB 219 4e-57 4MYG-A nrPDB 218 5e-57 1U5R-A nrPDB 218 8e-57 5HI2-A nrPDB 218 8e-57 6BSD-A nrPDB 217 9e-57 3QUP-A nrPDB 217 1e-56 2GCD-A nrPDB 217 2e-56 5AWM-A nrPDB 216 2e-56 3OMV-A nrPDB 216 3e-56 3BBT-B nrPDB 216 3e-56 4EQM-A nrPDB 216 3e-56 3GC9-A nrPDB 215 3e-56 2WTK-C nrPDB 215 4e-56 3E7O-A nrPDB 215 4e-56 3DLS-A nrPDB 215 6e-56 1JNK-A nrPDB 215 6e-56 5U6B-A nrPDB 214 8e-56 3C1X-A nrPDB 214 9e-56 5AIR-A nrPDB 214 9e-56 1TKI-A nrPDB 214 9e-56 3LZB-A nrPDB 214 1e-55 4E7W-A nrPDB 214 1e-55 5HIE-A nrPDB 213 2e-55 3PP0-A nrPDB 213 2e-55 5GNK-A nrPDB 213 2e-55 3FI2-A nrPDB 212 3e-55 2XS0-A nrPDB 212 3e-55 5HLW-A nrPDB 212 4e-55 1S9I-A nrPDB 212 5e-55 1U59-A nrPDB 211 1e-54 3BGP-A nrPDB 210 1e-54 2W96-B nrPDB 210 2e-54 1ZXE-A nrPDB 210 2e-54 5B2L-A nrPDB 210 2e-54 5TUR-A nrPDB 210 2e-54 4IDT-A nrPDB 209 3e-54 4LRM-A nrPDB 209 3e-54 4X7Q-B nrPDB 209 4e-54 2OZO-A nrPDB 208 6e-54 1A25-A nrPDB 208 6e-54 5O2B-A nrPDB 208 7e-54 4RC3-A nrPDB 208 8e-54 5U6C-A nrPDB 207 1e-53 3AOX-A nrPDB 207 1e-53 3ALO-A nrPDB 207 2e-53 6FER-A nrPDB 207 2e-53 4PWN-A nrPDB 206 2e-53 3IO7-A nrPDB 206 2e-53 2W1I-A nrPDB 206 3e-53 6GVJ-A nrPDB 206 3e-53 6DBM-A nrPDB 205 3e-53 5O2C-A nrPDB 205 3e-53 4YFF-A nrPDB 205 5e-53 4OLI-A nrPDB 204 9e-53 2I6L-A nrPDB 204 1e-52 4OW8-A nrPDB 204 1e-52 4X3F-A nrPDB 204 1e-52 6B2Q-A nrPDB 204 1e-52 3PLS-A nrPDB 203 3e-52 3M42-A nrPDB 202 3e-52 5AP3-A nrPDB 202 5e-52 4M7I-A nrPDB 202 5e-52 4NEU-A nrPDB 202 6e-52 5WNO-A nrPDB 201 7e-52 4DNL-A nrPDB 201 7e-52 3ZZW-A nrPDB 201 8e-52 5Y86-A nrPDB 201 8e-52 4HVI-A nrPDB 199 4e-51 5X8I-B nrPDB 198 5e-51 2UZP-A nrPDB 198 6e-51 4E20-A nrPDB 198 8e-51 6DBN-A nrPDB 197 1e-50 3N9X-A nrPDB 197 2e-50 3PG1-A nrPDB 196 2e-50 3NIE-A nrPDB 196 2e-50 5ZTN-A nrPDB 196 3e-50 4FL3-A nrPDB 195 3e-50 5HVK-A nrPDB 195 7e-50 5C26-A nrPDB 195 7e-50 2WO6-A nrPDB 195 7e-50 3E3P-A nrPDB 194 8e-50 5VD3-A nrPDB 194 1e-49 6CTH-A nrPDB 194 1e-49 5O0Y-A nrPDB 194 2e-49 4G3E-A nrPDB 193 2e-49 4C59-A nrPDB 193 2e-49 3QA8-A nrPDB 193 2e-49 4TPT-A nrPDB 192 3e-49 6FYV-A nrPDB 192 6e-49 4F0G-A nrPDB 192 6e-49 4Y83-A nrPDB 191 6e-49 4KIK-B nrPDB 191 6e-49 3RP9-A nrPDB 190 1e-48 2A1A-B nrPDB 189 4e-48 3LMG-A nrPDB 189 5e-48 5TQX-A nrPDB 188 8e-48 5UNP-A nrPDB 185 4e-47 5UIU-A nrPDB 185 5e-47 3EB0-A nrPDB 185 8e-47 5TOS-A nrPDB 184 8e-47 3UIU-A nrPDB 183 3e-46 6J5U-C nrPDB 182 6e-46 5TE0-A nrPDB 180 2e-45 2RIO-A nrPDB 180 2e-45 6O6Q-A nrPDB 179 3e-45 5L2Q-C nrPDB 179 3e-45 2H34-A nrPDB 179 4e-45 2PMN-X nrPDB 179 5e-45 5CEK-A nrPDB 178 7e-45 6DC0-A nrPDB 178 8e-45 3RAW-A nrPDB 177 1e-44 4JLC-A nrPDB 177 2e-44 3Q4U-A nrPDB 177 2e-44 4IAN-A nrPDB 176 2e-44 5AR8-A nrPDB 176 2e-44 5WNL-A nrPDB 175 4e-44 4EUU-A nrPDB 175 4e-44 3QD2-B nrPDB 175 4e-44 4EUT-A nrPDB 175 5e-44 5LPZ-A nrPDB 174 1e-43 3UIM-A nrPDB 174 2e-43 5LPV-A nrPDB 174 2e-43 6NT9-A nrPDB 173 2e-43 6O8B-A nrPDB 172 4e-43 4MD7-E nrPDB 172 4e-43 3LLT-A nrPDB 171 7e-43 5IKW-A nrPDB 170 2e-42 3MDY-A nrPDB 170 2e-42 2BUJ-A nrPDB 170 2e-42 6HMD-A nrPDB 169 3e-42 6EII-A nrPDB 169 4e-42 2PVN-A nrPDB 168 4e-42 2QKW-B nrPDB 168 9e-42 3MY0-A nrPDB 167 2e-41 5XVU-A nrPDB 165 6e-41 3REP-A nrPDB 165 7e-41 5VC6-A nrPDB 161 8e-40 5XD6-A nrPDB 160 1e-39 6BFN-A nrPDB 160 2e-39 3HNG-A nrPDB 159 3e-39 2JD5-A nrPDB 159 4e-39 3VHK-A nrPDB 158 6e-39 5VDK-A nrPDB 157 2e-38 4PL5-B nrPDB 157 2e-38 4M66-A nrPDB 157 2e-38 2Y4I-B nrPDB 156 3e-38 6HV0-A nrPDB 155 6e-38 4CRL-A nrPDB 155 6e-38 4RT7-A nrPDB 151 1e-36 5W5C-F nrPDB 150 3e-36 4LFI-A nrPDB 149 3e-36 4M69-B nrPDB 149 3e-36 4BTF-A nrPDB 149 3e-36 4LDC-A nrPDB 147 1e-35 1RH8-A nrPDB 146 4e-35 2KI6-A nrPDB 145 7e-35 4F9B-A nrPDB 144 1e-34 5LOB-A nrPDB 144 1e-34 2CM5-A nrPDB 143 2e-34 3F01-A nrPDB 143 2e-34 1RSY-A nrPDB 143 3e-34 3RPB-A nrPDB 141 1e-33 6ANK-A nrPDB 140 2e-33 5H4Y-A nrPDB 140 2e-33 5M07-A nrPDB 138 5e-33 2CHL-A nrPDB 138 6e-33 6ANJ-A nrPDB 138 9e-33 2D8K-A nrPDB 138 1e-32 2C47-A nrPDB 137 1e-32 2CMW-A nrPDB 136 3e-32 2CHD-A nrPDB 135 4e-32 4LCV-A nrPDB 135 5e-32 4MJJ-A nrPDB 135 5e-32 4NT4-A nrPDB 135 6e-32 1DQV-A nrPDB 133 2e-31 5OAT-A nrPDB 129 4e-30 2E73-A nrPDB 127 2e-29 4TS6-A nrPDB 125 8e-29 2PZI-A nrPDB 125 9e-29 4Y12-A nrPDB 124 1e-28 1XA6-A nrPDB 124 1e-28 2ELI-A nrPDB 124 1e-28 6EQI-C nrPDB 123 3e-28 1TBN-A nrPDB 122 4e-28 2BWQ-A nrPDB 119 4e-27 2ENN-A nrPDB 119 5e-27 1W15-A nrPDB 116 2e-26 3N5A-A nrPDB 115 5e-26 3CXL-A nrPDB 115 5e-26 1UOW-A nrPDB 114 1e-25 3FDW-A nrPDB 113 2e-25 1UGK-A nrPDB 113 3e-25 6NYT-A nrPDB 112 4e-25 2YUU-A nrPDB 110 2e-24 5YQ3-A nrPDB 106 4e-23 4L9M-A nrPDB 105 5e-23 5IXC-A nrPDB 104 1e-22 3JZY-A nrPDB 104 2e-22 2Q3X-A nrPDB 103 4e-22 2DMG-A nrPDB 100 2e-21 4FKD-A nrPDB 100 2e-21 Sequences not found previously or not previously below threshold: 1PY5-A nrPDB 158 9e-39 3G2F-A nrPDB 151 7e-37 2WTK-B nrPDB 149 4e-36 5E8V-A nrPDB 148 7e-36 3SOC-A nrPDB 144 1e-34 5X18-A nrPDB 140 2e-33 2QLU-A nrPDB 137 2e-32 4MWI-A nrPDB 135 8e-32 4WUA-A nrPDB 133 3e-31 5FQD-C nrPDB 132 4e-31 3SV0-A nrPDB 132 7e-31 2X7G-A nrPDB 131 8e-31 4TN6-A nrPDB 129 3e-30 5X1R-A nrPDB 128 7e-30 4BTK-A nrPDB 128 9e-30 4NFN-A nrPDB 127 1e-29 4L00-A nrPDB 127 2e-29 1CSN-A nrPDB 124 1e-28 5USZ-A nrPDB 120 2e-27 5J0A-A nrPDB 119 5e-27 4I94-A nrPDB 113 4e-25 4XHH-A nrPDB 112 4e-25 4XHL-A nrPDB 112 6e-25 5C01-A nrPDB 110 2e-24 4WOV-A nrPDB 110 2e-24 4JRN-A nrPDB 107 2e-23 6J6I-B nrPDB 101 1e-21 >3PFQ-A nrPDB Length = 674 Score = 1016 bits (2627), Expect = 0.0, Method: Composition-based stats. Identities = 642/668 (96%), Positives = 650/668 (97%), Gaps = 1/668 (0%) Query: 1 MADPAAGPPPSEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGF 60 MADPAAGPPPSEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGF Sbjct: 2 MADPAAGPPPSEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGF 61 Query: 61 GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGS 120 GKQGFQCQVC FVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGS Sbjct: 62 GKQGFQCQVCSFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGS 121 Query: 121 LLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDREVLIVVVRDA 180 LLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDREVLIVVVRDA Sbjct: 122 LLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDREVLIVVVRDA 181 Query: 181 KNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRL 240 KNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIK SLNPEWNETFRFQLKESDKDRRL Sbjct: 182 KNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKSSLNPEWNETFRFQLKESDKDRRL 241 Query: 241 SVEIWDWDLTSRNDFMGSLSFGISELQKAGVDGWFKLLSQEEGEYFNVPVPPEGSEGNEE 300 SVEIWDWDLTSRNDFMGSLSFGISELQKAGVDGWFKLLSQEEGEYFNVPVPPEGSEGNEE Sbjct: 242 SVEIWDWDLTSRNDFMGSLSFGISELQKAGVDGWFKLLSQEEGEYFNVPVPPEGSEGNEE 301 Query: 301 LRQKFERAKIGQGTKAPEEKTANTISKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSE 360 LRQKFERAKIGQGTKAPEEKTANTISKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSE Sbjct: 302 LRQKFERAKIGQGTKAPEEKTANTISKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSE 361 Query: 361 RKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVM 420 RKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVM Sbjct: 362 RKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVM 421 Query: 421 EYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHI 480 EYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHI Sbjct: 422 EYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHI 481 Query: 481 KIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAP 540 KIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAP Sbjct: 482 KIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAP 541 Query: 541 FEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFF 600 FEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFF Sbjct: 542 FEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFF 601 Query: 601 RYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEFTRQPVELTPTDKLFIMNLDQNEFAGF 660 RYIDWEKLERKEIQPPYKPKA + + NFD+ FTR P LTP D+ I N+DQ+EF GF Sbjct: 602 RYIDWEKLERKEIQPPYKPKASGR-NAENFDRFFTRHPPVLTPPDQEVIRNIDQSEFEGF 660 Query: 661 SYTNPEFV 668 S+ N EF+ Sbjct: 661 SFVNSEFL 668 >2I0E-A nrPDB Length = 353 Score = 499 bits (1285), Expect = e-141, Method: Composition-based stats. Identities = 322/348 (92%), Positives = 331/348 (95%), Gaps = 1/348 (0%) Query: 321 TANTISKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQ 380 T NT+SKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQ Sbjct: 1 TTNTVSKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQ 60 Query: 381 DDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKE 440 DDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKE Sbjct: 61 DDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKE 120 Query: 441 PHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKT 500 PHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKT Sbjct: 121 PHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKT 180 Query: 501 FCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAY 560 FCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAY Sbjct: 181 FCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAY 240 Query: 561 PKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPK 620 PKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPK Sbjct: 241 PKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPK 300 Query: 621 ARDKRDTSNFDKEFTRQPVELTPTDKLFIMNLDQNEFAGFSYTNPEFV 668 A + + NFD+ FTR P LTP D+ I N+DQ+EF GFS+ N EF+ Sbjct: 301 ACGR-NAENFDRFFTRHPPVLTPPDQEVIRNIDQSEFEGFSFVNSEFL 347 >4RA4-A nrPDB Length = 355 Score = 487 bits (1253), Expect = e-138, Method: Composition-based stats. Identities = 281/340 (82%), Positives = 309/340 (90%), Gaps = 1/340 (0%) Query: 329 DNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTM 388 + N DR+KLTDFNFLMVLGKGSFGKVML++RKGT+ELYA+KILKKDVVIQDDDVECTM Sbjct: 9 QPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTM 68 Query: 389 VEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAA 448 VEKRVLAL KPPFLTQLHSCFQT+DRLYFVMEYVNGGDLMYHIQQVG+FKEP AVFYAA Sbjct: 69 VEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAA 128 Query: 449 EIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYI 508 EI+IGLFFL +GIIYRDLKLDNVMLDSEGHIKIADFGMCKE++ DGVTT+TFCGTPDYI Sbjct: 129 EISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYI 188 Query: 509 APEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEA 568 APEIIAYQPYGKSVDWWA+GVLLYEMLAGQ PF+GEDEDELFQSIMEHNV+YPKS+SKEA Sbjct: 189 APEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEA 248 Query: 569 VAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTS 628 V+ICKGLMTKHP KRLGCGPEGERD++EHAFFR IDWEKLE +EIQPP+KPK + Sbjct: 249 VSICKGLMTKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVSG-KGAE 307 Query: 629 NFDKEFTRQPVELTPTDKLFIMNLDQNEFAGFSYTNPEFV 668 NFDK FTR LTP D+L I N+DQ++F GFSY NP+FV Sbjct: 308 NFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVNPQFV 347 >3TXO-A nrPDB Length = 353 Score = 428 bits (1100), Expect = e-120, Method: Composition-based stats. Identities = 196/337 (58%), Positives = 246/337 (72%), Gaps = 1/337 (0%) Query: 332 GNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEK 391 + +R+ + +F F+ VLGKGSFGKVML+ K T +LYAVK+LKKDV++QDDDVECTM EK Sbjct: 15 NSSNRLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEK 74 Query: 392 RVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIA 451 R+L+L PFLTQL CFQT DRL+FVME+VNGGDLM+HIQ+ RF E A FYAAEI Sbjct: 75 RILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEII 134 Query: 452 IGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPE 511 L FL KGIIYRDLKLDNV+LD EGH K+ADFGMCKE I +GVTT TFCGTPDYIAPE Sbjct: 135 SALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPE 194 Query: 512 IIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAI 571 I+ YG +VDWWA GVLLYEML G APFE E+ED+LF++I+ V YP + ++A I Sbjct: 195 ILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGI 254 Query: 572 CKGLMTKHPGKRLG-CGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNF 630 K MTK+P RLG GE I H FF+ IDW +L ++I+PP++P+ + + D SNF Sbjct: 255 LKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNF 314 Query: 631 DKEFTRQPVELTPTDKLFIMNLDQNEFAGFSYTNPEF 667 D +F ++ LTP D+ + ++Q+EF F Y +PE Sbjct: 315 DPDFIKEEPVLTPIDEGHLPMINQDEFRNFEYVSPEL 351 >5F9E-A nrPDB Length = 353 Score = 416 bits (1070), Expect = e-116, Method: Composition-based stats. Identities = 192/332 (57%), Positives = 238/332 (71%), Gaps = 4/332 (1%) Query: 334 RDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRV 393 + ++K+ DF +LGKGSFGKV L+E K T++ +A+K LKKDVV+ DDDVECTMVEKRV Sbjct: 13 QIKLKIEDFELHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRV 72 Query: 394 LALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIG 453 L+L + PFLT + FQT + L+FVMEY+NGGDLMYHIQ +F A FYAAEI +G Sbjct: 73 LSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILG 132 Query: 454 LFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEII 513 L FL SKGI+YRDLKLDN++LD +GHIKIADFGMCKEN+ T FCGTPDYIAPEI+ Sbjct: 133 LQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNEFCGTPDYIAPEIL 192 Query: 514 AYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICK 573 Q Y SVDWW+FGVLLYEML GQ+PF G+DE+ELF SI N YP+ + KEA + Sbjct: 193 LGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEKEAKDLLV 252 Query: 574 GLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFDKE 633 L + P KRLG DI++H FR I+WE+LERKEI PP++PK + D SNFDKE Sbjct: 253 KLFVREPEKRLGVRG----DIRQHPLFREINWEELERKEIDPPFRPKVKSPFDCSNFDKE 308 Query: 634 FTRQPVELTPTDKLFIMNLDQNEFAGFSYTNP 665 F + L+ D+ I ++DQN F FS+ NP Sbjct: 309 FLNEKPRLSFADRALINSMDQNMFRNFSFMNP 340 >5KCV-A nrPDB Length = 460 Score = 414 bits (1064), Expect = e-116, Method: Composition-based stats. Identities = 160/366 (43%), Positives = 227/366 (62%), Gaps = 16/366 (4%) Query: 283 GEYFNVPVPPEGSEGNEELRQKFERAKIGQGTKAPEEKTANTISKFDNNGNRD------- 335 F+V P E EE + G +A E + S DN+G + Sbjct: 99 ERTFHVETPEE----REEWTTAIQTVADGLKKQAAAEMDFRSGSPSDNSGAEEMEVSLAK 154 Query: 336 ---RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKR 392 R+ + +F +L +LGKG+FGKV+L + K T YA+KILKK+V++ D+V T+ E R Sbjct: 155 PKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENR 214 Query: 393 VLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAI 452 VL + PFLT L FQT DRL FVMEY NGG+L +H+ + F E A FY AEI Sbjct: 215 VLQ-NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVS 273 Query: 453 GLFFLQS-KGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPE 511 L +L S K ++YRDLKL+N+MLD +GHIKI DFG+CKE I DG T KTFCGTP+Y+APE Sbjct: 274 ALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPE 333 Query: 512 IIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAI 571 ++ YG++VDWW GV++YEM+ G+ PF +D ++LF+ I+ + +P+++ EA ++ Sbjct: 334 VLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSL 393 Query: 572 CKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFD 631 GL+ K P +RLG G E ++I +H FF I W+ + K++ PP+KP+ + DT FD Sbjct: 394 LSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFD 453 Query: 632 KEFTRQ 637 +EFT Q Sbjct: 454 EEFTAQ 459 >2JDO-A nrPDB Length = 342 Score = 413 bits (1062), Expect = e-115, Method: Composition-based stats. Identities = 153/335 (45%), Positives = 220/335 (65%), Gaps = 8/335 (2%) Query: 336 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 395 ++ + DF++L +LGKG+FGKV+L K T YA+KIL+K+V+I D+V T+ E RVL Sbjct: 6 KVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQ 65 Query: 396 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 455 + PFLT L FQT DRL FVMEY NGG+L +H+ + F E A FY AEI L Sbjct: 66 -NTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALE 124 Query: 456 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAY 515 +L S+ ++YRD+KL+N+MLD +GHIKI DFG+CKE I DG T KTFCGTP+Y+APE++ Sbjct: 125 YLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLED 184 Query: 516 QPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGL 575 YG++VDWW GV++YEM+ G+ PF +D + LF+ I+ + +P+++S EA ++ GL Sbjct: 185 NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGL 244 Query: 576 MTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEFT 635 + K P +RLG GP +++ EH FF I+W+ + +K++ PP+KP+ + DT FD EFT Sbjct: 245 LKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFT 304 Query: 636 RQPVELTPTDK-------LFIMNLDQNEFAGFSYT 663 Q + +TP D+ +Q F F Y Sbjct: 305 AQSITITPPDRYDSLGLLELDQREEQEMFEDFDYI 339 >3A8W-A nrPDB Length = 345 Score = 408 bits (1050), Expect = e-114, Method: Composition-based stats. Identities = 174/344 (50%), Positives = 238/344 (69%), Gaps = 10/344 (2%) Query: 332 GNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEK 391 G D + L DF+ L V+G+GS+ KV+L K TD +YA+K++KK++V D+D++ EK Sbjct: 1 GAMDPLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEK 60 Query: 392 RVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIA 451 V PFL LHSCFQT RL+FV+EYVNGGDLM+H+Q+ + E HA FY+AEI+ Sbjct: 61 HVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEIS 120 Query: 452 IGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPE 511 + L +L +GIIYRDLKLDNV+LDSEGHIK+ D+GMCKE + G TT TFCGTP+YIAPE Sbjct: 121 LALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPE 180 Query: 512 IIAYQPYGKSVDWWAFGVLLYEMLAGQAPF---------EGEDEDELFQSIMEHNVAYPK 562 I+ + YG SVDWWA GVL++EM+AG++PF + ED LFQ I+E + P+ Sbjct: 181 ILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPR 240 Query: 563 SMSKEAVAICKGLMTKHPGKRLGCGPE-GERDIKEHAFFRYIDWEKLERKEIQPPYKPKA 621 S+S +A ++ K + K P +RLGC P+ G DI+ H FFR +DW+ +E+K++ PP+KP Sbjct: 241 SLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNI 300 Query: 622 RDKRDTSNFDKEFTRQPVELTPTDKLFIMNLDQNEFAGFSYTNP 665 + NFD +FT +PV+LTP D + +DQ+EF GF Y NP Sbjct: 301 SGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINP 344 >3MV5-A nrPDB Length = 342 Score = 404 bits (1038), Expect = e-113, Method: Composition-based stats. Identities = 153/332 (46%), Positives = 220/332 (66%), Gaps = 6/332 (1%) Query: 336 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 395 R+ + +F +L +LGKG+FGKV+L + K T YA+KILKK+V++ D+V T+ E RVL Sbjct: 6 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 65 Query: 396 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 455 + PFLT L FQT DRL FVMEY NGG+L +H+ + F E A FY AEI L Sbjct: 66 -NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALD 124 Query: 456 FLQS-KGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA 514 +L S K ++YRDLKL+N+MLD +GHIKI DFG+CKE I DG T KTFCGTP+Y+APE++ Sbjct: 125 YLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLE 184 Query: 515 YQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKG 574 YG++VDWW GV++YEM+ G+ PF +D ++LF+ I+ + +P+++ EA ++ G Sbjct: 185 DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSG 244 Query: 575 LMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEF 634 L+ K P +RLG G E ++I +H FF I W+ + K++ PP+KP+ + DT FD+EF Sbjct: 245 LLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEF 304 Query: 635 TRQPVELTPTDKL----FIMNLDQNEFAGFSY 662 T Q + +TP D+ + + + F F Y Sbjct: 305 TAQMITITPPDQDDSMECVDSERRPHFPQFDY 336 >4L42-A nrPDB Length = 346 Score = 398 bits (1022), Expect = e-111, Method: Composition-based stats. Identities = 133/344 (38%), Positives = 211/344 (61%), Gaps = 6/344 (1%) Query: 324 TISKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERK---GTDELYAVKILKKDVVIQ 380 +S+ N ++++ F L VLGKG +GKV + T +++A+K+LKK ++++ Sbjct: 2 AMSETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVR 61 Query: 381 D-DDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFK 439 + D T E+ +L K PF+ L FQT +LY ++EY++GG+L +++ G F Sbjct: 62 NAKDTAHTKAERNILE-EVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFM 120 Query: 440 EPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTK 499 E A FY AEI++ L L KGIIYRDLK +N+ML+ +GH+K+ DFG+CKE+I DG T Sbjct: 121 EDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTH 180 Query: 500 TFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVA 559 TFCGT +Y+APEI+ + ++VDWW+ G L+Y+ML G PF GE+ + I++ + Sbjct: 181 TFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLN 240 Query: 560 YPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKP 619 P +++EA + K L+ ++ RLG GP +++ H FFR+I+WE+L ++++PP+KP Sbjct: 241 LPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKP 300 Query: 620 KARDKRDTSNFDKEFTRQPVELTPTDKLFIMNLDQNEFAGFSYT 663 + + D S FD +FTRQ +P D + +Q F F Y Sbjct: 301 LLQSEEDVSQFDSKFTRQTPVDSPDDST-LSEEEQEMFRDFEYI 343 >3HDN-A nrPDB Length = 373 Score = 385 bits (989), Expect = e-107, Method: Composition-based stats. Identities = 150/334 (44%), Positives = 209/334 (62%), Gaps = 7/334 (2%) Query: 338 KLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALP 397 K +DF+FL V+GKGSFGKV+L+ K + YAVK+L+K +++ + + M E+ VL Sbjct: 36 KPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKN 95 Query: 398 GKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFL 457 K PFL LH FQT D+LYFV++Y+NGG+L YH+Q+ F EP A FYAAEIA L +L Sbjct: 96 VKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYL 155 Query: 458 QSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQP 517 S I+YRDLK +N++LDS+GHI + DFG+CKENI TT TFCGTP+Y+APE++ QP Sbjct: 156 HSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQP 215 Query: 518 YGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMT 577 Y ++VDWW G +LYEML G PF + E++ +I+ + +++ A + +GL+ Sbjct: 216 YDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQ 275 Query: 578 KHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEFTRQ 637 K KRLG + +IK H FF I+W+ L K+I PP+ P D +FD EFT + Sbjct: 276 KDRTKRLGA-KDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEE 334 Query: 638 PVE----LTPTDKLFIMNLDQ--NEFAGFSYTNP 665 PV P L ++ + F GFSY P Sbjct: 335 PVPNAIGKAPDSVLVTASVKEAAEAFLGFSYAPP 368 >4OTD-A nrPDB Length = 341 Score = 376 bits (965), Expect = e-104, Method: Composition-based stats. Identities = 156/330 (47%), Positives = 215/330 (65%), Gaps = 4/330 (1%) Query: 337 MKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLAL 396 + L DF FL VLG+G FGKV+LSE + + EL+A+K LKK ++ D+VE M EKR+LA Sbjct: 9 LTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAA 68 Query: 397 P--GKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGL 454 PFL L CFQT + + FVMEY GGDLM HI F EP A+FY+A + +GL Sbjct: 69 VTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHS-DVFSEPRAIFYSACVVLGL 127 Query: 455 FFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA 514 FL I+YRDLKLDN++LD+EG++KIADFG+CKE + G T TFCGTP+++APE++ Sbjct: 128 QFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLT 187 Query: 515 YQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKG 574 Y ++VDWW GVLLYEML G++PF G+DE+E+F SI+ V YP+ +S EA+ I + Sbjct: 188 DTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRR 247 Query: 575 LMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEF 634 L+ ++P +RLG D+K+ FFR + WE L + + PP+ P + D SNFD+EF Sbjct: 248 LLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFDEEF 307 Query: 635 TRQPVELTPT-DKLFIMNLDQNEFAGFSYT 663 T + L+P D + +Q F F + Sbjct: 308 TGEAPTLSPPRDARPLTAAEQAAFLDFDFV 337 >4CRS-A nrPDB Length = 341 Score = 375 bits (964), Expect = e-104, Method: Composition-based stats. Identities = 156/338 (46%), Positives = 219/338 (64%), Gaps = 4/338 (1%) Query: 329 DNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTM 388 + R + L DF VL +G FGKV+L+E K T+E++A+K LKK ++ D+V+ M Sbjct: 1 SMSQQRFQFNLQDFRCCAVLLRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLM 60 Query: 389 VEKRVLALPG--KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFY 446 EKR+ + PFL L +CFQT + + FVMEY GGDLM HI F EP AVFY Sbjct: 61 CEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIH-TDVFSEPRAVFY 119 Query: 447 AAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPD 506 AA + +GL +L I+YRDLKLDN++LD+EG +KIADFG+CKE + G T TFCGTP+ Sbjct: 120 AACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPE 179 Query: 507 YIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSK 566 ++APE++ Y ++VDWW GVL+YEML G++PF G+DE+E+F SI+ V YP+ +S Sbjct: 180 FLAPEVLTETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLST 239 Query: 567 EAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRD 626 EA++I + L+ ++P +RLG + D+K+H FFR IDW L K+++PP+ P R + D Sbjct: 240 EAISIMRRLLRRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGRED 299 Query: 627 TSNFDKEFTRQPVELTPTDKL-FIMNLDQNEFAGFSYT 663 SNFD EFT + LTP + + +Q F F Y Sbjct: 300 VSNFDDEFTSEAPILTPPREPRILSEEEQEMFRDFDYI 337 >5D9K-A nrPDB Length = 330 Score = 370 bits (950), Expect = e-102, Method: Composition-based stats. Identities = 131/308 (42%), Positives = 191/308 (62%), Gaps = 5/308 (1%) Query: 335 DRMKLTDFNFLMVLGKGSFGKVMLSERK---GTDELYAVKILKKDVVIQDDDVECTMVEK 391 ++ + F L VLG+GSFGKV L ++ +LYA+K+LKK + D V M E+ Sbjct: 25 EKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKM-ER 83 Query: 392 RVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIA 451 +L + PF+ +LH FQT +LY +++++ GGDL + + F E FY AE+A Sbjct: 84 DIL-VEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELA 142 Query: 452 IGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPE 511 + L L S GIIYRDLK +N++LD EGHIK+ DFG+ KE+I +FCGT +Y+APE Sbjct: 143 LALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPE 202 Query: 512 IIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAI 571 ++ + + +S DWW+FGVL++EML G PF+G+D E I++ + P+ +S EA ++ Sbjct: 203 VVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSL 262 Query: 572 CKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFD 631 + L ++P RLG GP+G +IK H+FF IDW KL R+EI PP+KP DT FD Sbjct: 263 LRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFD 322 Query: 632 KEFTRQPV 639 EFT + Sbjct: 323 PEFTAKTP 330 >5X3F-B nrPDB Length = 393 Score = 365 bits (938), Expect = e-101, Method: Composition-based stats. Identities = 127/328 (38%), Positives = 188/328 (57%), Gaps = 4/328 (1%) Query: 305 FERAKIGQGTKAPEEKTANTISKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGT 364 AK +A K K +++ +L F+ + LG GSFG+VML + K + Sbjct: 49 LAEAKKLNDVQAFLAKAKEDFLKKWETPSQNTAQLDQFDRIKTLGTGSFGRVMLVKHKES 108 Query: 365 DELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVN 424 YA+KIL K V++ +E T+ EKR+L PFL +L F+ LY VMEYV Sbjct: 109 GNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNF-PFLVKLEFSFKDNSNLYMVMEYVA 167 Query: 425 GGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIAD 484 GG++ H++++GRF EPHA FYAA+I + +L S +IYRDLK +N+++D +G+I++ D Sbjct: 168 GGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTD 227 Query: 485 FGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGE 544 FG K T T CGTP+Y+APEII + Y K+VDWWA GVL+YEM AG PF + Sbjct: 228 FGFAKRVKG---RTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFAD 284 Query: 545 DEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYID 604 ++++ I+ V +P S + + + L+ KR G G DIK H +F D Sbjct: 285 QPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTD 344 Query: 605 WEKLERKEIQPPYKPKARDKRDTSNFDK 632 W + +++++ P+ PK + DTSNFD Sbjct: 345 WIAIYQRKVEAPFIPKFKGPGDTSNFDD 372 >5N23-A nrPDB Length = 352 Score = 365 bits (937), Expect = e-101, Method: Composition-based stats. Identities = 129/328 (39%), Positives = 189/328 (57%), Gaps = 6/328 (1%) Query: 308 AKIGQGTKAPEEKTANTISKF---DNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGT 364 AK G ++ +E A F + ++ L F + LG GSFG+VML + K T Sbjct: 7 AKKGSEQESVKEFLAKAKEDFLKKWESPAQNTAHLDQFERIRTLGTGSFGRVMLVKHKET 66 Query: 365 DELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVN 424 YA+KIL K V++ +E T+ EKR+ PFL +L F+ LY V+EY Sbjct: 67 GNHYAMKILDKQKVVKLKQIEHTLNEKRI-QQAVNFPFLVKLEFSFKDNSNLYMVLEYAP 125 Query: 425 GGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIAD 484 GG++ H++++GRF EPHA FYAA+I + +L S +IYRDLK +N+++D +G+IK+AD Sbjct: 126 GGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIKVAD 185 Query: 485 FGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGE 544 FG K G T T CGTP+Y+APEII + Y K+VDWWA GVL+YEM AG PF + Sbjct: 186 FGFAKRVK--GRTPWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFAD 243 Query: 545 DEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYID 604 ++++ I+ V +P S + + + L+ KR G G DIK H +F D Sbjct: 244 QPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTD 303 Query: 605 WEKLERKEIQPPYKPKARDKRDTSNFDK 632 W + +++++ P+ PK + DTSNFD Sbjct: 304 WIAIYQRKVEAPFIPKFKGPGDTSNFDD 331 >4WB7-A nrPDB Length = 405 Score = 362 bits (930), Expect = e-100, Method: Composition-based stats. Identities = 127/322 (39%), Positives = 185/322 (57%), Gaps = 4/322 (1%) Query: 311 GQGTKAPEEKTANTISKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAV 370 G+ K K K + ++ L F + LG GSFG+VML + K T YA+ Sbjct: 67 GEEVKEFLAKAKEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAM 126 Query: 371 KILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMY 430 KIL K V++ +E T+ EKR+L PFL +L F+ LY VMEYV GG++ Sbjct: 127 KILDKQKVVKLKQIEHTLNEKRILQAVNF-PFLVKLEFSFKDNSNLYMVMEYVPGGEMFS 185 Query: 431 HIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKE 490 H++++GRF EPHA FYAA+I + +L S +IYRDLK +N+++D +G+I++ DFG K Sbjct: 186 HLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKR 245 Query: 491 NIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELF 550 T T CGTP+Y+APEII + Y K+VDWWA GVL+YEM AG PF + +++ Sbjct: 246 VKG---RTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIY 302 Query: 551 QSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLER 610 + I+ V +P S + + + L+ KR G G DIK H +F DW + + Sbjct: 303 EKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQ 362 Query: 611 KEIQPPYKPKARDKRDTSNFDK 632 ++++ P+ PK + DTSNFD Sbjct: 363 RKVEAPFIPKFKGPGDTSNFDD 384 >2Z7Q-A nrPDB Length = 321 Score = 361 bits (927), Expect = e-100, Method: Composition-based stats. Identities = 129/300 (43%), Positives = 185/300 (61%), Gaps = 5/300 (1%) Query: 335 DRMKLTDFNFLMVLGKGSFGKVMLSERK---GTDELYAVKILKKDVVIQDDDVECTMVEK 391 ++ + F L VLG+GSFGKV L + + LYA+K+LKK + D V M E+ Sbjct: 23 EKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKM-ER 81 Query: 392 RVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIA 451 +LA PF+ +LH FQT +LY +++++ GGDL + + F E FY AE+A Sbjct: 82 DILADVN-HPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELA 140 Query: 452 IGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPE 511 +GL L S GIIYRDLK +N++LD EGHIK+ DFG+ KE I +FCGT +Y+APE Sbjct: 141 LGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPE 200 Query: 512 IIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAI 571 ++ Q + S DWW++GVL++EML G PF+G+D E I++ + P+ +S EA ++ Sbjct: 201 VVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSL 260 Query: 572 CKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFD 631 + L ++P RLG GP+G +IK H F+ IDW KL R+EI+PP+KP DT FD Sbjct: 261 LRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFD 320 >1VZO-A nrPDB Length = 355 Score = 358 bits (919), Expect = 4e-99, Method: Composition-based stats. Identities = 137/352 (38%), Positives = 202/352 (57%), Gaps = 28/352 (7%) Query: 290 VPPEGSEGNEELRQKFERAKIGQGTKAPEEKTANTISKFDNNGNRDRMKLTDFNFLMVLG 349 +G +G E+L T E +TAN G+ +++ + +F L VLG Sbjct: 21 TSADGGDGGEQLL-----------TVKHELRTANL------TGHAEKVGIENFELLKVLG 63 Query: 350 KGSFGKVMLSER---KGTDELYAVKILKKDVVIQD-DDVECTMVEKRVLALPGKPPFLTQ 405 G++GKV L + T +LYA+K+LKK ++Q E T E++VL + PFL Sbjct: 64 TGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVT 123 Query: 406 LHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYR 465 LH FQT +L+ +++Y+NGG+L H+ Q RF E Y EI + L L GIIYR Sbjct: 124 LHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYR 183 Query: 466 DLKLDNVMLDSEGHIKIADFGMCKENIWDG-VTTKTFCGTPDYIAPEIIAYQ--PYGKSV 522 D+KL+N++LDS GH+ + DFG+ KE + D FCGT +Y+AP+I+ + K+V Sbjct: 184 DIKLENILLDSNGHVVLTDFGLSKEFVADETERAYDFCGTIEYMAPDIVRGGDSGHDKAV 243 Query: 523 DWWAFGVLLYEMLAGQAPF----EGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTK 578 DWW+ GVL+YE+L G +PF E + E+ + I++ YP+ MS A + + L+ K Sbjct: 244 DWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMK 303 Query: 579 HPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNF 630 P KRLGCGP +IKEH FF+ I+W+ L K++ P+KP RD+ D SNF Sbjct: 304 DPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRDELDVSNF 355 >1FOT-A nrPDB Length = 318 Score = 353 bits (906), Expect = 2e-97, Method: Composition-based stats. Identities = 123/321 (38%), Positives = 188/321 (58%), Gaps = 8/321 (2%) Query: 336 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 395 + L DF L LG GSFG+V L + YA+K+LKK++V++ VE T E+ +L+ Sbjct: 2 KYSLQDFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLS 61 Query: 396 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 455 + PF+ ++ FQ +++ +M+Y+ GG+L +++ RF P A FYAAE+ + L Sbjct: 62 IVT-HPFIIRMWGTFQDAQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALE 120 Query: 456 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAY 515 +L SK IIYRDLK +N++LD GHIKI DFG K T T CGTPDYIAPE+++ Sbjct: 121 YLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPD---VTYTLCGTPDYIAPEVVST 177 Query: 516 QPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGL 575 +PY KS+DWW+FG+L+YEMLAG PF + + ++ I+ + +P +++ + L Sbjct: 178 KPYNKSIDWWSFGILIYEMLAGYTPFYDSNTMKTYEKILNAELRFPPFFNEDVKDLLSRL 237 Query: 576 MTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKA-RDKRDTSNFDK-- 632 +T+ +RLG G D+K H +F+ + WEKL + I+ PY+P + + DTS FDK Sbjct: 238 ITRDLSQRLGNLQNGTEDVKNHPWFKEVVWEKLLSRNIETPYEPPIQQGQGDTSQFDKYP 297 Query: 633 -EFTRQPVELTPTDKLFIMNL 652 E V+ + Sbjct: 298 EEDINYGVQGEDPYADLFRDF 318 >4RLP-A nrPDB Length = 288 Score = 352 bits (904), Expect = 2e-97, Method: Composition-based stats. Identities = 117/288 (40%), Positives = 186/288 (64%), Gaps = 5/288 (1%) Query: 336 RMKLTDFNFLMVLGKGSFGKVMLSERK---GTDELYAVKILKKDVVIQD-DDVECTMVEK 391 +++ F L VLGKG +GKV + T +++A+K+LKK +++++ D T E+ Sbjct: 1 KIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAER 60 Query: 392 RVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIA 451 +L K PF+ L FQT +LY ++EY++GG+L +++ G F E A FY AEI+ Sbjct: 61 NILE-EVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEIS 119 Query: 452 IGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPE 511 + L L KGIIYRDLK +N+ML+ +GH+K+ DFG+CKE+I DG T TFCGT +Y+APE Sbjct: 120 MALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPE 179 Query: 512 IIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAI 571 I+ + ++VDWW+ G L+Y+ML G PF GE+ + I++ + P +++EA + Sbjct: 180 ILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDL 239 Query: 572 CKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKP 619 K L+ ++ RLG GP +++ H FFR+I+WE+L ++++PP+KP Sbjct: 240 LKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKP 287 >4AW2-A nrPDB Length = 437 Score = 346 bits (889), Expect = 1e-95, Method: Composition-based stats. Identities = 121/353 (34%), Positives = 184/353 (52%), Gaps = 19/353 (5%) Query: 326 SKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVE 385 F + + R+ DF L V+G+G+FG+V + + K D+++A+KIL K +++ + Sbjct: 60 KPFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETA 119 Query: 386 CTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQ-VGRFKEPHAV 444 C E+ VL + G ++T LH FQ + LY VM+Y GGDL+ + + R E A Sbjct: 120 CFREERDVL-VNGDSKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEEMAR 178 Query: 445 FYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTF-CG 503 FY AE+ I + + ++RD+K DN+++D GHI++ADFG C + + DG + G Sbjct: 179 FYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVG 238 Query: 504 TPDYIAPEIIA-----YQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHN- 557 TPDYI+PEI+ YG DWW+ GV +YEML G+ PF E E + IM H Sbjct: 239 TPDYISPEILQAMEGGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKE 298 Query: 558 -VAYP---KSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEI 613 +P +S+ A + + L+ RLG G D K+H FF IDW+ + + Sbjct: 299 RFQFPTQVTDVSENAKDLIRRLIC-SREHRLG--QNGIEDFKKHPFFSGIDWDNI--RNC 353 Query: 614 QPPYKPKARDKRDTSNFD-KEFTRQPVELTPTDKLFIMNLDQNEFAGFSYTNP 665 + PY P+ DTSNFD + + E P + F GF+YT+ Sbjct: 354 EAPYIPEVSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSS 406 >6E9W-A nrPDB Length = 443 Score = 342 bits (878), Expect = 3e-94, Method: Composition-based stats. Identities = 130/356 (36%), Positives = 186/356 (52%), Gaps = 20/356 (5%) Query: 322 ANTISKFDNNGNRDR---MKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVV 378 N +S++ + N+ R MK D+ + V+G+G+FG+V L K T ++YA+K+L K + Sbjct: 81 DNFLSRYKDTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEM 140 Query: 379 IQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRF 438 I+ D E+ ++A P++ QL FQ LY VMEY+ GGDL+ + Sbjct: 141 IKRSDSAFFWEERDIMAFAN-SPWVVQLFYAFQDDRYLYMVMEYMPGGDLVN-LMSNYDV 198 Query: 439 KEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDG-VT 497 E A FY AE+ + L + S G I+RD+K DN++LD GH+K+ADFG C + +G V Sbjct: 199 PEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVR 258 Query: 498 TKTFCGTPDYIAPEIIAYQP----YGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSI 553 T GTPDYI+PE++ Q YG+ DWW+ GV LYEML G PF + + I Sbjct: 259 CDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKI 318 Query: 554 MEHN--VAYPK--SMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLE 609 M H + +P +SKEA + +T RLG G +IK H FF+ W Sbjct: 319 MNHKNSLTFPDDNDISKEAKNLICAFLT-DREVRLG--RNGVEEIKRHLFFKNDQWAWET 375 Query: 610 RKEIQPPYKPKARDKRDTSNFDK-EFTRQPVELTPTDKLFIMNLDQNEFAGFSYTN 664 ++ P P DTSNFD E + E P K F+ N Q F GF+Y + Sbjct: 376 LRDTVAPVVPDLSSDIDTSNFDDLEEDKGEEETFPIPKAFVGN--QLPFVGFTYYS 429 >3TKU-A nrPDB Length = 433 Score = 341 bits (875), Expect = 6e-94, Method: Composition-based stats. Identities = 118/342 (34%), Positives = 182/342 (53%), Gaps = 19/342 (5%) Query: 336 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 395 ++ DF + V+G+G+FG+V + + K T+ +YA+KIL K +++ + C E+ VL Sbjct: 86 QLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVL- 144 Query: 396 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQ-VGRFKEPHAVFYAAEIAIGL 454 + G ++T LH FQ + LY VM+Y GGDL+ + + + E A FY E+ + + Sbjct: 145 VNGDCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAI 204 Query: 455 FFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTF-CGTPDYIAPEII 513 + ++RD+K DNV+LD GHI++ADFG C + DG + GTPDYI+PEI+ Sbjct: 205 DSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEIL 264 Query: 514 AY-----QPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIM--EHNVAYPKS--- 563 YG DWW+ GV +YEML G+ PF E E + IM E +P Sbjct: 265 QAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVTD 324 Query: 564 MSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARD 623 +S+EA + + L+ +RLG G D K+HAFF ++WE + + ++ PY P Sbjct: 325 VSEEAKDLIQRLIC-SRERRLG--QNGIEDFKKHAFFEGLNWENI--RNLEAPYIPDVSS 379 Query: 624 KRDTSNFD-KEFTRQPVELTPTDKLFIMNLDQNEFAGFSYTN 664 DTSNFD + + E+ P + F GF++T Sbjct: 380 PSDTSNFDVDDDVLRNTEILPPGSHTGFSGLHLPFIGFTFTT 421 >6ED6-A nrPDB Length = 415 Score = 340 bits (871), Expect = 2e-93, Method: Composition-based stats. Identities = 124/337 (36%), Positives = 182/337 (54%), Gaps = 17/337 (5%) Query: 336 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 395 +MK D++ + V+G+G+FG+V L K + ++YA+K+L K +I+ D E+ ++A Sbjct: 84 QMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMA 143 Query: 396 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 455 P++ QL FQ LY VMEY+ GGDL+ + E A FY AE+ + L Sbjct: 144 FAN-SPWVVQLFYAFQDDRYLYMVMEYMPGGDLVN-LMSNYDVPEKWAKFYTAEVVLALD 201 Query: 456 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDG-VTTKTFCGTPDYIAPEIIA 514 + S G+I+RD+K DN++LD GH+K+ADFG C + G V T GTPDYI+PE++ Sbjct: 202 AIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLK 261 Query: 515 YQP----YGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHN--VAYPKS--MSK 566 Q YG+ DWW+ GV LYEML G PF + + IM+H + +P+ +SK Sbjct: 262 SQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISK 321 Query: 567 EAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRD 626 A + +T RLG G +I++H FF+ W +E P P+ D Sbjct: 322 HAKNLICAFLT-DREVRLG--RNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDID 378 Query: 627 TSNFDK-EFTRQPVELTPTDKLFIMNLDQNEFAGFSY 662 +SNFD E + VE P K F+ N Q F GF+Y Sbjct: 379 SSNFDDIEDDKGDVETFPIPKAFVGN--QLPFIGFTY 413 >6BDL-A nrPDB Length = 347 Score = 339 bits (870), Expect = 2e-93, Method: Composition-based stats. Identities = 116/313 (37%), Positives = 174/313 (55%), Gaps = 6/313 (1%) Query: 336 RMKLTDFNFLMVLGKGSFGKVMLSERK-GTDELYAVKILKKDVVIQDDDVECTMVEKRVL 394 +KL+DFN + LG G FG+V L + K + +A+KILKK ++ E EK+++ Sbjct: 30 NLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIM 89 Query: 395 ALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGL 454 F+ +L+ F+ LY +ME GG+L ++ G F++ FY A + Sbjct: 90 Q-GAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAF 148 Query: 455 FFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA 514 +L SKGIIYRDLK +N++LD G+ K+ DFG K+ + G T TFCGTP+Y+APEII Sbjct: 149 AYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGF-GKKTWTFCGTPEYVAPEIIL 207 Query: 515 YQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHN--VAYPKSMSKEAVAIC 572 + + S D+W+ G+L+YE+L G PF G D + + I+ + +PK ++K A + Sbjct: 208 NKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLI 267 Query: 573 KGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFDK 632 K L +P +RLG G +DI++H +F +WE L + + PP P DTSNFD Sbjct: 268 KKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDS 327 Query: 633 EFTRQPVELTPTD 645 F E P D Sbjct: 328 -FPEDNDEPPPDD 339 >5LOH-A nrPDB Length = 341 Score = 325 bits (833), Expect = 4e-89, Method: Composition-based stats. Identities = 121/339 (35%), Positives = 194/339 (57%), Gaps = 19/339 (5%) Query: 313 GTKAPEEKTANTISKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKI 372 G+K A T + + +F+ + + +G+FGKV L ++ +LYAVK+ Sbjct: 9 GSKKEPGGGAATEEGVNRIAVPKPPSIEEFSIVKPISRGAFGKVYLGQK--GGKLYAVKV 66 Query: 373 LKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHI 432 +KK +I + E+ LAL K PF+ L+ Q+ + +Y VMEY+ GGD+ + Sbjct: 67 VKKADMINKNMTHQVQAERDALAL-SKSPFIVHLYYSLQSANNVYLVMEYLIGGDVKSLL 125 Query: 433 QQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKE-- 490 G F E AV Y +E+A+ L +L GII+RDLK DN+++ +EGHIK+ DFG+ K Sbjct: 126 HIYGYFDEEMAVKYISEVALALDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTL 185 Query: 491 ----NIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDE 546 N+ D +TT+TFCGTPDY+APE++ + +G +VDWWA GV L+E L G PF E Sbjct: 186 NRDINMMDILTTRTFCGTPDYLAPELLLGRAHGPAVDWWALGVCLFEFLTGIPPFNDETP 245 Query: 547 DELFQSIMEHNVAYP---KSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYI 603 ++FQ+I++ ++ +P + +S A + + L+T KR G +++K H F + Sbjct: 246 QQVFQNILKRDIPWPEGEEKLSDNAQSAVEILLTIDDTKRAGM-----KELKRHPLFSDV 300 Query: 604 DWEKLERKEIQPPYKPKARDKRDTSNFDKEFTRQPVELT 642 DWE L+ + + P+ P+ D+ DTS F+ T Q + ++ Sbjct: 301 DWENLQHQTM--PFIPQPDDETDTSYFEARNTAQHLTVS 337 >5FET-A nrPDB Length = 847 Score = 317 bits (812), Expect = 1e-86, Method: Composition-based stats. Identities = 104/317 (32%), Positives = 172/317 (54%), Gaps = 10/317 (3%) Query: 336 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 395 ++++ + ++G+G+FG V L K T YA+K + K +I + +E+ + A Sbjct: 529 KVEMHELETERIIGRGTFGTVKLVHHKPTQIRYALKCVSKRSIISLNQQNNIKLEREITA 588 Query: 396 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 455 PF+ +L F+ + YF+ E V GG+L I+++G +P A FY I + + Sbjct: 589 -ENDHPFIIRLVRTFKDSNCFYFLTELVTGGELYDAIRKLGLLSKPQAQFYLGSIILAIE 647 Query: 456 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAY 515 +L + I+YRDLK +N++LD +G++K+ DFG K+ T GTP Y+APE+I Sbjct: 648 YLHERNIVYRDLKPENILLDKQGYVKLIDFGCAKKIQGRAY---TLVGTPHYMAPEVILG 704 Query: 516 QPYGKSVDWWAFGVLLYEMLAGQAPF--EGEDEDELFQSIMEHNVAYPKSMSK-EAVAIC 572 + YG +VD WA GV LYE + G PF + ED+ E+F+ I+ + +P +S +++ + Sbjct: 705 KGYGCTVDIWALGVCLYEFICGPLPFGNDQEDQLEIFRDILTGQLTFPDYVSDQDSINLM 764 Query: 573 KGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPK---ARDKRDTSN 629 K L+ + P R+GC G +DIKEHAFF +W+KL + ++PP K + D Sbjct: 765 KRLLCRLPQGRIGCSINGFKDIKEHAFFGNFNWDKLAGRLLEPPLVSKGETYAEDIDIKQ 824 Query: 630 FDKEFTRQPVELTPTDK 646 ++E E D Sbjct: 825 IEEEDALNEGEPLDGDD 841 >4TNB-A nrPDB Length = 590 Score = 314 bits (805), Expect = 7e-86, Method: Composition-based stats. Identities = 119/328 (36%), Positives = 181/328 (55%), Gaps = 10/328 (3%) Query: 333 NRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKR 392 R + F VLGKG FG+V + + T ++YA K L+K + + + EK+ Sbjct: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQ 236 Query: 393 VLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR--FKEPHAVFYAAEI 450 +L F+ L ++T D L V+ +NGGDL +HI +G F+E A+FYAAEI Sbjct: 237 ILEKVN-SQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEI 295 Query: 451 AIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAP 510 GL L + +YRDLK +N++LD GHI+I+D G+ + I +G + GT Y+AP Sbjct: 296 LCGLEDLHHENTVYRDLKPENILLDDYGHIRISDLGLAVK-IPEGDLIRGRVGTVGYMAP 354 Query: 511 EIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDE----DELFQSIMEHNVAYPKSMSK 566 E++ Q YG S D+W G L+YEM+ GQ+PF G E +E+ + ++E Y S+ Sbjct: 355 EVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSE 414 Query: 567 EAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARD--K 624 EA +ICK L+TK +RLGC E ++K H FFR +++++LE + PP+ P R Sbjct: 415 EAKSICKMLLTKDAKQRLGCQEEEAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYC 474 Query: 625 RDTSNFDKEFTRQPVELTPTDKLFIMNL 652 +D + ++ T + V L TD F Sbjct: 475 KDVLDIEQFSTVKGVNLDHTDDDFYSKF 502 >3NYO-A nrPDB Length = 576 Score = 313 bits (802), Expect = 2e-85, Method: Composition-based stats. Identities = 119/328 (36%), Positives = 185/328 (56%), Gaps = 10/328 (3%) Query: 333 NRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKR 392 R + F VLGKG FG+V + + T ++YA K L+K + + + EK+ Sbjct: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQ 236 Query: 393 VLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR--FKEPHAVFYAAEI 450 +L F+ L ++T D L V+ +NGGDL +HI +G+ F E AVFYAAEI Sbjct: 237 ILEKVN-SRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEI 295 Query: 451 AIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAP 510 GL L + I+YRDLK +N++LD GHI+I+D G+ ++ +G T K GT Y+AP Sbjct: 296 CCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAV-HVPEGQTIKGRVGTVGYMAP 354 Query: 511 EIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGED----EDELFQSIMEHNVAYPKSMSK 566 E++ + Y S DWWA G LLYEM+AGQ+PF+ +E+ + + E Y + S Sbjct: 355 EVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSP 414 Query: 567 EAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARD--K 624 +A ++C L+ K P +RLGC R++KEH F+ +++++L ++PP+KP + Sbjct: 415 QARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYC 474 Query: 625 RDTSNFDKEFTRQPVELTPTDKLFIMNL 652 +D + ++ T + VEL PTD+ F Sbjct: 475 KDVLDIEQFSTVKGVELEPTDQDFYQKF 502 >5UUU-A nrPDB Length = 547 Score = 311 bits (797), Expect = 7e-85, Method: Composition-based stats. Identities = 106/327 (32%), Positives = 178/327 (54%), Gaps = 14/327 (4%) Query: 337 MKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLAL 396 + + DF+ ++G+G FG+V + T ++YA+K L K + + E+ +L+L Sbjct: 195 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 254 Query: 397 P--GKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGL 454 G PF+ + F T D+L F+++ +NGGDL YH+ Q G F E FYAAEI +GL Sbjct: 255 VSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGL 314 Query: 455 FFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA 514 + ++ ++YRDLK N++LD GH++I+D G+ + GT Y+APE++ Sbjct: 315 EHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDF--SKKKPHASVGTHGYMAPEVLQ 372 Query: 515 YQP-YGKSVDWWAFGVLLYEMLAGQAPFEGE---DEDELFQSIMEHNVAYPKSMSKEAVA 570 Y S DW++ G +L+++L G +PF D+ E+ + + V P S S E + Sbjct: 373 KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRS 432 Query: 571 ICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKP-----KARDKR 625 + +GL+ + +RLGC G +++KE FFR +DW+ + ++ PP P A D Sbjct: 433 LLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAF 492 Query: 626 DTSNFDKEFTRQPVELTPTDKLFIMNL 652 D +FD+E T+ ++L +D+ N Sbjct: 493 DIGSFDEEDTKG-IKLLDSDQELYRNF 518 >5DYK-A nrPDB Length = 853 Score = 311 bits (796), Expect = 9e-85, Method: Composition-based stats. Identities = 96/299 (32%), Positives = 164/299 (54%), Gaps = 9/299 (3%) Query: 336 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 395 ++++ + ++G+G+FG V L K T YA+K + K +I + +E+ + A Sbjct: 535 KVEMDELETERIIGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINLNQQNNIKLEREITA 594 Query: 396 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 455 PF+ +L F+ YF+ E V GG+L I+++G + A FY I + + Sbjct: 595 -ENDHPFIIRLVRTFKDSKYFYFLTELVTGGELYDAIRKLGLLSKSQAQFYLGSIILAIE 653 Query: 456 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAY 515 +L + I+YRDLK +N++LD +G++K+ DFG K+ T GTP Y+APE+I Sbjct: 654 YLHERNIVYRDLKPENILLDKQGYVKLIDFGCAKKVQGRAY---TLVGTPHYMAPEVILG 710 Query: 516 QPYGKSVDWWAFGVLLYEMLAGQAPF--EGEDEDELFQSIMEHNVAYPKSMSK-EAVAIC 572 + YG +VD WA G+ LYE + G PF + ED+ E+F+ I+ + +P ++ +++ + Sbjct: 711 KGYGCTVDIWALGICLYEFICGPLPFGNDEEDQLEIFRDILTGQLTFPDYVTDTDSINLM 770 Query: 573 KGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFD 631 K L+ + P R+GC G +DIK+H FF +W+KL + + PP K + + D Sbjct: 771 KRLLCRLPQGRIGCSINGFKDIKDHPFFSNFNWDKLAGRLLDPPLVSK--SETYAEDID 827 >3PVW-A nrPDB Length = 695 Score = 310 bits (795), Expect = 1e-84, Method: Composition-based stats. Identities = 106/327 (32%), Positives = 178/327 (54%), Gaps = 14/327 (4%) Query: 337 MKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLAL 396 + + DF+ ++G+G FG+V + T ++YA+K L K + + E+ +L+L Sbjct: 186 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 245 Query: 397 P--GKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGL 454 G PF+ + F T D+L F+++ +NGGDL YH+ Q G F E FYAAEI +GL Sbjct: 246 VSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGL 305 Query: 455 FFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA 514 + ++ ++YRDLK N++LD GH++I+D G+ + GT Y+APE++ Sbjct: 306 EHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDF--SKKKPHASVGTHGYMAPEVLQ 363 Query: 515 YQP-YGKSVDWWAFGVLLYEMLAGQAPFEGE---DEDELFQSIMEHNVAYPKSMSKEAVA 570 Y S DW++ G +L+++L G +PF D+ E+ + + V P S S E + Sbjct: 364 KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRS 423 Query: 571 ICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKP-----KARDKR 625 + +GL+ + +RLGC G +++KE FFR +DW+ + ++ PP P A D Sbjct: 424 LLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAF 483 Query: 626 DTSNFDKEFTRQPVELTPTDKLFIMNL 652 D +FD+E T+ ++L +D+ N Sbjct: 484 DIGSFDEEDTKG-IKLLDSDQELYRNF 509 >4LQP-A nrPDB Length = 508 Score = 307 bits (786), Expect = 1e-83, Method: Composition-based stats. Identities = 113/407 (27%), Positives = 177/407 (43%), Gaps = 84/407 (20%) Query: 340 TDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK 399 DF+ + V+GKG+FG+V L ++K T ++YA+K L K + + D + E+ VLA Sbjct: 102 EDFHTVKVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKDQLAHVKAERDVLA-GSD 160 Query: 400 PPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQS 459 P++ L+ FQ LY +ME++ GGDLM + + F E FY AE + + + Sbjct: 161 SPWVVSLYYSFQDAQYLYLIMEFLPGGDLMTMLIRWQLFTEDVTRFYMAECILAIETIHK 220 Query: 460 KGIIYRDLKLDNVMLDSEGHIKIADFGMCK--ENIWDGVTTK------------------ 499 G I+R +K DN+++D GHIK++DFG+ D K Sbjct: 221 LGFIHRAIKPDNILIDIRGHIKLSDFGLSTGFHKTHDSNYYKKLLQQDEATNGISKPGTY 280 Query: 500 ------------------------------TFCGTPDYIA-----------PEIIAYQPY 518 T+ + +A PEI YQ Y Sbjct: 281 NANTTDTANKRQTMVVDSISLTMSNRQQIQTWRKSRRLMAYSTVGTPDYIAPEIFLYQGY 340 Query: 519 GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIM--EHNVAYPK--SMSKEAVAICKG 574 G+ DWW+ G ++YE L G PF E E ++ IM E + +P +S EA + + Sbjct: 341 GQECDWWSLGAIMYECLIGWPPFCSETPQETYRKIMNFEQTLQFPDDIHISYEAEDLIRR 400 Query: 575 LMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEF 634 L+T H +RLG G +IK H FFR +DW + ++++ PY PK DT F Sbjct: 401 LLT-HADQRLGRHG-GADEIKSHPFFRGVDWNTI--RQVEAPYIPKLSSITDTRFF-PTD 455 Query: 635 TRQPVELTPTDKLFIMNLDQ-------------NEFAGFSYTNPEFV 668 + V +P +Q F G+ Y+ +++ Sbjct: 456 ELENVPDSPAMAQAAKQREQMTKQGGSAPVKEDLPFIGYEYSRFDYL 502 >3ORZ-A nrPDB Length = 316 Score = 306 bits (785), Expect = 2e-83, Method: Composition-based stats. Identities = 105/312 (33%), Positives = 169/312 (54%), Gaps = 6/312 (1%) Query: 308 AKIGQGTKAPEEKTANTISKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDEL 367 + GT A A ++ + + DF F +LG+GSF V+L+ T Sbjct: 5 PEFMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSRE 64 Query: 368 YAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGD 427 YA+KIL+K +I+++ V E+ V++ PF +L+ CFQ ++LYF + Y G+ Sbjct: 65 YAIKILEKRHIIKENKVPYVTRERDVMSRLD-HPFFVKLYFCFQDDEKLYFGLSYAKNGE 123 Query: 428 LMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGM 487 L+ +I+++G F E FY AEI L +L KGII+RDLK +N++L+ + HI+I DFG Sbjct: 124 LLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGT 183 Query: 488 CKENIWDGVTTK--TFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGED 545 K + + +F GT Y++PE++ + KS D WA G ++Y+++AG PF + Sbjct: 184 AKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGN 243 Query: 546 EDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGP-EGERDIKEHAFFRYID 604 E +FQ I++ +P+ +A + + L+ KRLGC EG +K H FF + Sbjct: 244 EYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVT 303 Query: 605 WEKLERKEIQPP 616 WE L ++ PP Sbjct: 304 WENLHQQ--TPP 313 >4C0T-A nrPDB Length = 974 Score = 306 bits (783), Expect = 3e-83, Method: Composition-based stats. Identities = 99/335 (29%), Positives = 169/335 (50%), Gaps = 16/335 (4%) Query: 293 EGSEGNEELRQKFERAKIGQGTKAPEEKTA--NTISKFDNNGNRDRMKLTDFNFLMVLGK 350 E E N++ + + + Q + E+K A TI D R +TDF F LG+ Sbjct: 217 EEEENNDDTDEIPKSETLKQNEENWEKKGAAVKTIKTMDGEMKTIRRNVTDFKFGKELGE 276 Query: 351 GSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCF 410 GS+ V+L+ K T + YAVK+L K +I++ V+ +EK L + L+ F Sbjct: 277 GSYSTVILATDKITGKQYAVKVLDKRHIIKEKKVKYVNIEKHALNRLSNRLGVISLYFTF 336 Query: 411 QTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLD 470 Q D LYFV++Y + G+L+ I++ E + A+I + ++ G+I+RDLK + Sbjct: 337 QDKDSLYFVLDYASNGELLTLIKRYNTLNEECTRHFGAQILDAIKYMHDNGVIHRDLKPE 396 Query: 471 NVMLDSEGHIKIADFGMCK---------ENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKS 521 N++LD + I+I DFG + E V K+F GT +Y++PE++ + GK Sbjct: 397 NILLDDKMRIQITDFGTARLLEKKNDESEEYPVDVRAKSFVGTAEYVSPELLENKYCGKP 456 Query: 522 VDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPG 581 D WAFG ++Y+M+AG+ PF+ +E FQ I + A+ + K ++ P Sbjct: 457 GDVWAFGCIIYQMIAGKPPFKATNEYLTFQKITKLQFAFSAGFPTIIRDLIKKILVLQPS 516 Query: 582 KRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPP 616 +R +I++H FF+ +D++ + + P Sbjct: 517 RRATI-----PEIQKHYFFQSVDFKDFDSIWLSDP 546 >2VD5-A nrPDB Length = 412 Score = 306 bits (783), Expect = 3e-83, Method: Composition-based stats. Identities = 119/347 (34%), Positives = 177/347 (51%), Gaps = 26/347 (7%) Query: 336 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 395 R++ DF L V+G+G+F +V + + K T ++YA+KI+ K +++ +V C E+ VL Sbjct: 57 RLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVL- 115 Query: 396 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVG-RFKEPHAVFYAAEIAIGL 454 + G ++TQLH FQ + LY VMEY GGDL+ + + G R A FY AEI + + Sbjct: 116 VNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAI 175 Query: 455 FFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTK-TFCGTPDYIAPEII 513 + G ++RD+K DN++LD GHI++ADFG C + DG GTPDY++PEI+ Sbjct: 176 DSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEIL 235 Query: 514 A-------YQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIM--EHNVAYP--- 561 YG DWWA GV YEM GQ PF + E + I+ + +++ P Sbjct: 236 QAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVD 295 Query: 562 KSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKA 621 + + +EA + L+ P RLG G G D + H FF +DW+ L ++ PP+ P Sbjct: 296 EGVPEEARDFIQRLLCP-PETRLGRG--GAGDFRTHPFFFGLDWDGL--RDSVPPFTPDF 350 Query: 622 RDKRDTSNFD------KEFTRQPVELTPTDKLFIMNLDQNEFAGFSY 662 DT NFD E + F G+SY Sbjct: 351 EGATDTCNFDLVEDGLTAMVSGGGETLSDIREGAPLGVHLPFVGYSY 397 >2QNJ-A nrPDB Length = 328 Score = 302 bits (773), Expect = 3e-82, Method: Composition-based stats. Identities = 85/299 (28%), Positives = 146/299 (48%), Gaps = 17/299 (5%) Query: 332 GNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEK 391 G+ ++ + ++ L +GKG+F KV L+ T A+KI+ K + ++ E Sbjct: 4 GSDEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDK-TQLNPTSLQKLFREV 62 Query: 392 RVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIA 451 R++ + P + +L +T LY +MEY +GG++ ++ GR KE A +I Sbjct: 63 RIMKILN-HPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIV 121 Query: 452 IGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPE 511 + + K I++RDLK +N++LD++ +IKIADFG E G TFCG+P Y APE Sbjct: 122 SAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTV-GGKLDTFCGSPPYAAPE 180 Query: 512 IIAYQPYG-KSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVA 570 + + Y VD W+ GV+LY +++G PF+G++ EL + ++ P MS + Sbjct: 181 LFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCEN 240 Query: 571 ICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSN 629 + K + +P KR I + + + + KP + D S+ Sbjct: 241 LLKRFLVLNPIKR-----GTLEQIMKDRW--------INAGHEEDELKPFVEPELDISD 286 >3C51-A nrPDB Length = 543 Score = 302 bits (773), Expect = 4e-82, Method: Composition-based stats. Identities = 118/321 (36%), Positives = 167/321 (52%), Gaps = 11/321 (3%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 F VLG+G FG+V + K T +LYA K L K + + + MVEK++LA Sbjct: 187 FLDFRVLGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILAKV-HSR 245 Query: 402 FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR----FKEPHAVFYAAEIAIGLFFL 457 F+ L F+T L VM +NGGD+ YHI V F+EP A+FY A+I GL L Sbjct: 246 FIVSLAYAFETKTDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQIVSGLEHL 305 Query: 458 QSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQP 517 + IIYRDLK +NV+LD +G+++I+D G+ E TK + GTP ++APE++ + Sbjct: 306 HQRNIIYRDLKPENVLLDDDGNVRISDLGLAVELKAGQTKTKGYAGTPGFMAPELLLGEE 365 Query: 518 YGKSVDWWAFGVLLYEMLAGQAPFEGE----DEDELFQSIMEHNVAYPKSMSKEAVAICK 573 Y SVD++A GV LYEM+A + PF + EL Q ++E V YP S + C+ Sbjct: 366 YDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKQRVLEQAVTYPDKFSPASKDFCE 425 Query: 574 GLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFD-- 631 L+ K P KRLG ++ H FR I W +LE + PP+ P +R + D Sbjct: 426 ALLQKDPEKRLGFRDGSCDGLRTHPLFRDISWRQLEAGMLTPPFVPDSRTVYAKNIQDVG 485 Query: 632 KEFTRQPVELTPTDKLFIMNL 652 T + V D F Sbjct: 486 AFSTVKGVAFEKADTEFFQEF 506 >5KZ7-A nrPDB Length = 346 Score = 301 bits (772), Expect = 5e-82, Method: Composition-based stats. Identities = 90/295 (30%), Positives = 148/295 (50%), Gaps = 11/295 (3%) Query: 335 DRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVL 394 ++ + ++ L +GKG+F KV L+ T + AVKI+ K + ++ E R++ Sbjct: 28 EQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDK-TQLNSSSLQKLFREVRIM 86 Query: 395 ALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGL 454 + P + +L +T LY VMEY +GG++ ++ GR KE A +I + Sbjct: 87 KVLN-HPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAV 145 Query: 455 FFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA 514 + K I++RDLK +N++LD++ +IKIADFG E + G TFCG+P Y APE+ Sbjct: 146 QYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTF-GNKLDTFCGSPPYAAPELFQ 204 Query: 515 YQPYG-KSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICK 573 + Y VD W+ GV+LY +++G PF+G++ EL + ++ P MS + + K Sbjct: 205 GKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLK 264 Query: 574 GLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTS 628 + +P KR I + + + E E K P P +D R T Sbjct: 265 KFLILNPSKR-----GTLEQIMKDRWM-NVGHEDDELKPYVEPL-PDYKDPRRTE 312 >5ES1-A nrPDB Length = 328 Score = 298 bits (764), Expect = 4e-81, Method: Composition-based stats. Identities = 86/283 (30%), Positives = 140/283 (49%), Gaps = 10/283 (3%) Query: 335 DRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVL 394 ++ + ++ L +GKG+F KV L+ T A+KI+ K + ++ E R++ Sbjct: 10 EQPHVGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDK-TQLNPSSLQKLFREVRIM 68 Query: 395 ALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGL 454 P + +L +T LY VMEY + G++ ++ GR KE A +I + Sbjct: 69 KGLN-HPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAV 127 Query: 455 FFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA 514 + K I++RDLK +N++LD+E +IKIADFG E G TFCG+P Y APE+ Sbjct: 128 HYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTL-GSKLDTFCGSPPYAAPELFQ 186 Query: 515 YQPYG-KSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICK 573 + Y VD W+ GV+LY +++G PF+G + EL + ++ P MS + +I + Sbjct: 187 GKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILR 246 Query: 574 GLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPP 616 + +P KR I + + I +E E K P Sbjct: 247 RFLVLNPAKRCTL-----EQIMKDKWI-NIGYEGEELKPYTEP 283 >4REW-A nrPDB Length = 540 Score = 297 bits (760), Expect = 1e-80, Method: Composition-based stats. Identities = 87/267 (32%), Positives = 145/267 (54%), Gaps = 8/267 (2%) Query: 337 MKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLAL 396 +K+ + LG G+FGKV + + + T AVKIL + + D V E + L L Sbjct: 3 VKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKL 62 Query: 397 PGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFF 456 + P + +L+ T ++ VMEYV+GG+L +I + GR E + +I G+ + Sbjct: 63 F-RHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDY 121 Query: 457 LQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQ 516 +++RDLK +NV+LD+ + KIADFG+ + DG +T CG+P+Y APE+I+ + Sbjct: 122 CHRHMVVHRDLKPENVLLDAHMNAKIADFGLSN-MMSDGEFLRTSCGSPNYAAPEVISGR 180 Query: 517 PY-GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGL 575 Y G VD W+ GV+LY +L G PF+ + LF+ I + P+ ++ +++ K + Sbjct: 181 LYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHM 240 Query: 576 MTKHPGKRLGCGPEGERDIKEHAFFRY 602 + P KR +DI+EH +F+ Sbjct: 241 LQVDPMKRASI-----KDIREHEWFKQ 262 >3MN3-A nrPDB Length = 271 Score = 296 bits (759), Expect = 2e-80, Method: Composition-based stats. Identities = 84/264 (31%), Positives = 140/264 (53%), Gaps = 9/264 (3%) Query: 339 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 398 + ++ + LG+GSFGKV L+ T + A+KI+ K V+ + D E L L Sbjct: 3 IGNYQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLL- 61 Query: 399 KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQ 458 + P + +L+ ++ D + V+EY G +L +I Q + E A + +I + + Sbjct: 62 RHPHIIKLYDVIKSKDEIIMVIEYA-GNELFDYIVQRDKMSEQEARRFFQQIISAVEYCH 120 Query: 459 SKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY 518 I++RDLK +N++LD ++KIADFG+ + DG KT CG+P+Y APE+I+ + Y Sbjct: 121 RHKIVHRDLKPENLLLDEHLNVKIADFGLSN-IMTDGNFLKTSCGSPNYAAPEVISGKLY 179 Query: 519 -GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMT 577 G VD W+ GV+LY ML + PF+ E LF++I PK +S A + K ++ Sbjct: 180 AGPEVDVWSCGVILYVMLCRRLPFDDESIPVLFKNISNGVYTLPKFLSPGAAGLIKRMLI 239 Query: 578 KHPGKRLGCGPEGERDIKEHAFFR 601 +P R+ +I + +F+ Sbjct: 240 VNPLNRISI-----HEIMQDDWFK 258 >4CFF-A nrPDB Length = 571 Score = 296 bits (757), Expect = 3e-80, Method: Composition-based stats. Identities = 95/303 (31%), Positives = 151/303 (49%), Gaps = 18/303 (5%) Query: 336 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 395 R+K+ + LG G+FGKV + E + T AVKIL + + D V E + L Sbjct: 29 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK 88 Query: 396 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 455 L + P + +L+ T + VMEYV+GG+L +I + GR +E A +I + Sbjct: 89 LF-RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVD 147 Query: 456 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAY 515 + +++RDLK +NV+LD+ + KIADFG+ + DG +T CG+P+Y APE+I+ Sbjct: 148 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSN-MMSDGEFLRTSCGSPNYAAPEVISG 206 Query: 516 QPY-GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKG 574 + Y G VD W+ GV+LY +L G PF+ E LF+ I P+ +++ + Sbjct: 207 RLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMH 266 Query: 575 LMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEF 634 ++ P KR +DI+EH +F K+ P Y D + D E Sbjct: 267 MLQVDPLKRATI-----KDIREHEWF----------KQDLPSYLFPEDPSYDANVIDDEA 311 Query: 635 TRQ 637 ++ Sbjct: 312 VKE 314 >4D28-A nrPDB Length = 446 Score = 295 bits (756), Expect = 3e-80, Method: Composition-based stats. Identities = 75/278 (26%), Positives = 142/278 (51%), Gaps = 8/278 (2%) Query: 338 KLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALP 397 ++ + +G+G+F KV + T + A+KI+ K ++++ V+ E ++ + Sbjct: 7 RVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIV 66 Query: 398 GKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFL 457 + P + +L+ + ++Y V+E+V GG+L I GR KE + Y ++ + Sbjct: 67 -RHPNIVRLYEVLASKSKIYIVLEFVTGGELFDRIVHKGRLKEDESRKYFQQLVDAVAHC 125 Query: 458 QSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQP 517 SKG+ +RDLK +N++LD+ G++K++DFG+ CGTP+Y+APE+++ Q Sbjct: 126 HSKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLNDTCGTPNYVAPEVLSGQG 185 Query: 518 YG-KSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLM 576 Y + D W+ GV+L+ +LAG PF D L++ I P S E + ++ Sbjct: 186 YDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFDCPPWFSAEVKFLIHRIL 245 Query: 577 TKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQ 614 +P R+ IK+ +FR ++ + +E + Sbjct: 246 DPNPKTRIQIQG-----IKKDPWFRK-NYVPIRAREEE 277 >4CFH-A nrPDB Length = 493 Score = 295 bits (755), Expect = 5e-80, Method: Composition-based stats. Identities = 88/268 (32%), Positives = 146/268 (54%), Gaps = 8/268 (2%) Query: 336 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 395 R+K+ + LG G+FGKV + + + T AVKIL + + D V E + L Sbjct: 29 RVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLK 88 Query: 396 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 455 L + P + +L+ T ++ VMEYV+GG+L +I + GR E + +I G+ Sbjct: 89 LF-RHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVD 147 Query: 456 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAY 515 + +++RDLK +NV+LD+ + KIADFG+ + DG +T CG+P+Y APE+I+ Sbjct: 148 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSN-MMSDGEFLRTSCGSPNYAAPEVISG 206 Query: 516 QPY-GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKG 574 + Y G VD W+ GV+LY +L G PF+ + LF+ I + P+ ++ +++ K Sbjct: 207 RLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKH 266 Query: 575 LMTKHPGKRLGCGPEGERDIKEHAFFRY 602 ++ P KR +DI+EH +F+ Sbjct: 267 MLQVDPMKRATI-----KDIREHEWFKQ 289 >4RED-A nrPDB Length = 351 Score = 295 bits (755), Expect = 5e-80, Method: Composition-based stats. Identities = 87/267 (32%), Positives = 145/267 (54%), Gaps = 8/267 (2%) Query: 337 MKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLAL 396 +K+ + LG G+FGKV + + + T AVKIL + + D V E + L L Sbjct: 11 VKIGHYILGDTLGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLDVVGKIRREIQNLKL 70 Query: 397 PGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFF 456 + P + +L+ T ++ VMEYV+GG+L +I + GR E + +I G+ + Sbjct: 71 F-RHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDY 129 Query: 457 LQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQ 516 +++RDLK +NV+LD+ + KIADFG+ + DG +T CG+P+Y APE+I+ + Sbjct: 130 CHRHMVVHRDLKPENVLLDAHMNAKIADFGLSN-MMSDGEFLRTSCGSPNYAAPEVISGR 188 Query: 517 PY-GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGL 575 Y G VD W+ GV+LY +L G PF+ + LF+ I + P+ ++ +++ K + Sbjct: 189 LYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHM 248 Query: 576 MTKHPGKRLGCGPEGERDIKEHAFFRY 602 + P KR +DI+EH +F+ Sbjct: 249 LQVDPMKRASI-----KDIREHEWFKQ 270 >6BXI-A nrPDB Length = 333 Score = 294 bits (754), Expect = 6e-80, Method: Composition-based stats. Identities = 101/337 (29%), Positives = 165/337 (48%), Gaps = 45/337 (13%) Query: 336 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 395 R+ L DF L V+G+G+FG+V L ++K T +YA+KIL+K +++ + V E+ +L Sbjct: 2 RLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDIL- 60 Query: 396 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 455 + ++ ++ FQ LY +ME++ GGD+M + + E FY AE + + Sbjct: 61 VEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAID 120 Query: 456 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVT------------------ 497 + G I+RD+K DN++LDS+GH+K++DFG+C T Sbjct: 121 SIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQN 180 Query: 498 -----------------TKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAP 540 + GTPDYIAPE+ Y K DWW+ GV++YEML G P Sbjct: 181 MNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPP 240 Query: 541 FEGEDEDELFQSIM--EHNVAYPKS--MSKEAVAICKGLMTKHPGKRLGCGPEGERDIKE 596 F E E ++ +M + + +P +S++A + R+G G +IK Sbjct: 241 FCSETPQETYKKVMNWKETLTFPPEVPISEKAKDLILRFCC-EWEHRIGA--PGVEEIKS 297 Query: 597 HAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFDKE 633 ++FF +DWE + + + + DTSNFD+ Sbjct: 298 NSFFEGVDWEHIRER--PAAISIEIKSIDDTSNFDEF 332 >5EZV-A nrPDB Length = 560 Score = 294 bits (754), Expect = 6e-80, Method: Composition-based stats. Identities = 95/303 (31%), Positives = 151/303 (49%), Gaps = 18/303 (5%) Query: 336 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 395 R+K+ + LG G+FGKV + E + T AVKIL + + D V E + L Sbjct: 24 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK 83 Query: 396 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 455 L + P + +L+ T + VMEYV+GG+L +I + GR +E A +I + Sbjct: 84 LF-RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVD 142 Query: 456 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAY 515 + +++RDLK +NV+LD+ + KIADFG+ + DG +T CG+P+Y APE+I+ Sbjct: 143 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSN-MMSDGEFLRTSCGSPNYAAPEVISG 201 Query: 516 QPY-GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKG 574 + Y G VD W+ GV+LY +L G PF+ E LF+ I P+ +++ + Sbjct: 202 RLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMH 261 Query: 575 LMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEF 634 ++ P KR +DI+EH +F K+ P Y D + D E Sbjct: 262 MLQVDPLKRATI-----KDIREHEWF----------KQDLPSYLFPEDPSYDANVIDDEA 306 Query: 635 TRQ 637 ++ Sbjct: 307 VKE 309 >4YHJ-A nrPDB Length = 584 Score = 294 bits (754), Expect = 7e-80, Method: Composition-based stats. Identities = 117/328 (35%), Positives = 180/328 (54%), Gaps = 10/328 (3%) Query: 333 NRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKR 392 R + F VLGKG FG+V + + T ++YA K L+K + + + EKR Sbjct: 178 ERQPVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKR 237 Query: 393 VLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR--FKEPHAVFYAAEI 450 +L + F+ L ++T D L V+ +NGGDL +HI +G F E AVFYAAE+ Sbjct: 238 ILEKV-QSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAEL 296 Query: 451 AIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAP 510 GL LQ + I+YRDLK +N++LD GHI+I+D G+ E I +G + GT Y+AP Sbjct: 297 CCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATE-IPEGQRVRGRVGTVGYMAP 355 Query: 511 EIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDE----DELFQSIMEHNVAYPKSMSK 566 E++ + Y S DWW G L+YEM+ G +PF+ E +E+ Q I Y + S+ Sbjct: 356 EVVNNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSE 415 Query: 567 EAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARD--K 624 +A +IC+ L+TK+P KRLGC EG +K+H F+ I++ +LE ++PP+ P Sbjct: 416 DAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYC 475 Query: 625 RDTSNFDKEFTRQPVELTPTDKLFIMNL 652 +D + ++ + + L D+ F Sbjct: 476 KDVLDIEQFSVVKGIYLDTADEDFYARF 503 >5JN2-A nrPDB Length = 525 Score = 293 bits (750), Expect = 2e-79, Method: Composition-based stats. Identities = 81/276 (29%), Positives = 137/276 (49%), Gaps = 15/276 (5%) Query: 340 TDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK 399 + VLGKGSFG+V+L + K T + AVK++ K V Q D E + E ++L Sbjct: 67 DRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLD- 125 Query: 400 PPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQS 459 P + +L+ F+ Y V E GG+L I RF E A ++ G+ ++ Sbjct: 126 HPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHK 185 Query: 460 KGIIYRDLKLDNVMLDS---EGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQ 516 I++RDLK +N++L+S + +I+I DFG+ K GT YIAPE++ Sbjct: 186 NKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHF-EASKKMKDKIGTAYYIAPEVLHG- 243 Query: 517 PYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAY----PKSMSKEAVAIC 572 Y + D W+ GV+LY +L+G PF G +E ++ + + + + K +S+ A + Sbjct: 244 TYDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFELPQWKKVSESAKDLI 303 Query: 573 KGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKL 608 + ++T P R+ RD +H + + E++ Sbjct: 304 RKMLTYVPSMRISA-----RDALDHEWIQTYTKEQI 334 >3D2K-A nrPDB Length = 272 Score = 293 bits (750), Expect = 2e-79, Method: Composition-based stats. Identities = 81/270 (30%), Positives = 136/270 (50%), Gaps = 8/270 (2%) Query: 332 GNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEK 391 G++ + L DF+ LGKG FG V L+ + + + A+K+L K ++ VE + + Sbjct: 4 GSKRQWTLEDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFK-TQLEKAGVEHQLRRE 62 Query: 392 RVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIA 451 + + P + +L+ F R+Y ++EY G + +Q++ RF E Y E+A Sbjct: 63 VEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSRFDEQRTATYITELA 122 Query: 452 IGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPE 511 L + SK +I+RD+K +N++L S G +KIADFG T CGT DY+ PE Sbjct: 123 NALSYCHSKRVIHRDIKPENLLLGSNGELKIADFGWSVH--APSSRRTTLCGTLDYLPPE 180 Query: 512 IIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAI 571 +I + + + VD W+ GVL YE L G PFE E ++ I +P +++ A + Sbjct: 181 MIEGRMHDEKVDLWSLGVLCYEFLVGMPPFEAHTYQETYRRISRVEFTFPDFVTEGARDL 240 Query: 572 CKGLMTKHPGKRLGCGPEGERDIKEHAFFR 601 L+ + +RL ++ EH + + Sbjct: 241 ISRLLKHNASQRLTLA-----EVLEHPWIK 265 >4JXF-A nrPDB Length = 266 Score = 293 bits (750), Expect = 2e-79, Method: Composition-based stats. Identities = 76/266 (28%), Positives = 131/266 (49%), Gaps = 7/266 (2%) Query: 338 KLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALP 397 K+ DF +LGKGSF V +E T A+K++ K + + V+ E ++ Sbjct: 5 KIEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQL 64 Query: 398 GKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQV-GRFKEPHAVFYAAEIAIGLFF 456 K P + +L++ F+ + +Y V+E + G++ +++ F E A + +I G+ + Sbjct: 65 -KHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLY 123 Query: 457 LQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQ 516 L S GI++RDL L N++L +IKIADFG+ + T CGTP+YI+PEI Sbjct: 124 LHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRS 183 Query: 517 PYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLM 576 +G D W+ G + Y +L G+ PF+ + ++ + P +S EA + L+ Sbjct: 184 AHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLL 243 Query: 577 TKHPGKRLGCGPEGERDIKEHAFFRY 602 ++P RL + +H F Sbjct: 244 RRNPADRLSLSS-----VLDHPFMSR 264 >5FG8-A nrPDB Length = 285 Score = 293 bits (749), Expect = 2e-79, Method: Composition-based stats. Identities = 80/268 (29%), Positives = 128/268 (47%), Gaps = 14/268 (5%) Query: 340 TDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK 399 +++ LGKG+F V +K T +A KI+ + D + E R+ Sbjct: 14 DNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTAR-DFQKLEREARI-CRKLH 71 Query: 400 PPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQS 459 P + +LH Q + Y V + V GG+L I + E A +I + Sbjct: 72 HPNIVRLHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQ 131 Query: 460 KGIIYRDLKLDNVMLDSEGH---IKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQ 516 G+++RDLK +N++L S+ +K+ADFG+ E D F GTP Y++PE++ + Sbjct: 132 NGVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKE 191 Query: 517 PYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYP----KSMSKEAVAIC 572 PYGKSVD WA GV+LY +L G PF ED+ L+ I YP +++ EA + Sbjct: 192 PYGKSVDIWACGVILYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLI 251 Query: 573 KGLMTKHPGKRLGCGPEGERDIKEHAFF 600 ++T +P KR+ + +H + Sbjct: 252 NQMLTVNPNKRITAA-----EALKHPWI 274 >2YZA-A nrPDB Length = 276 Score = 291 bits (746), Expect = 5e-79, Method: Composition-based stats. Identities = 88/268 (32%), Positives = 141/268 (52%), Gaps = 8/268 (2%) Query: 336 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 395 R+K+ + LG G+FGKV + E + T AVKIL + + D V E + L Sbjct: 7 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK 66 Query: 396 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 455 L + P + +L+ T + VMEYV+GG+L +I + GR +E A +I + Sbjct: 67 LF-RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVD 125 Query: 456 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAY 515 + +++RDLK +NV+LD+ + KIADFG+ + DG + CG+P+Y APE+I+ Sbjct: 126 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSN-MMSDGEFLRDSCGSPNYAAPEVISG 184 Query: 516 QPY-GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKG 574 + Y G VD W+ GV+LY +L G PF+ E LF+ I P+ +++ + Sbjct: 185 RLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMH 244 Query: 575 LMTKHPGKRLGCGPEGERDIKEHAFFRY 602 ++ P KR +DI+EH +F+ Sbjct: 245 MLQVDPLKRATI-----KDIREHEWFKQ 267 >4CZT-A nrPDB Length = 464 Score = 291 bits (745), Expect = 7e-79, Method: Composition-based stats. Identities = 75/270 (27%), Positives = 141/270 (52%), Gaps = 9/270 (3%) Query: 336 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 395 R ++ + LG+G+F KV + + A+K++ K+ V+++ + E + Sbjct: 7 RTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMK 66 Query: 396 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 455 L K P + ++ + ++YFV+E+V GG+L I GR KE A Y ++ + Sbjct: 67 LI-KHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVD 125 Query: 456 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCK--ENIWDGVTTKTFCGTPDYIAPEII 513 + S+G+ +RDLK +N++LD+ G +K++DFG+ + + + T CGTP+Y+APE+I Sbjct: 126 YCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVI 185 Query: 514 AYQPYG-KSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAIC 572 + Y D W+ GV+L+ ++AG PFE + L++ I + P S A + Sbjct: 186 NNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLI 245 Query: 573 KGLMTKHPGKRLGCGPEGERDIKEHAFFRY 602 K ++ +P R+ ++ E+ +F+ Sbjct: 246 KRILDPNPATRIT-----FAEVIENEWFKK 270 >2VN9-A nrPDB Length = 301 Score = 289 bits (741), Expect = 2e-78, Method: Composition-based stats. Identities = 80/268 (29%), Positives = 125/268 (46%), Gaps = 14/268 (5%) Query: 340 TDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK 399 ++ LGKG+F V + T + YA KI+ + D + E R+ K Sbjct: 4 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDH-QKLEREARI-CRLLK 61 Query: 400 PPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQS 459 P + +LH Y V + V GG+L I + E A +I + Sbjct: 62 HPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHL 121 Query: 460 KGIIYRDLKLDNVMLDSEGH---IKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQ 516 GI++RDLK +N++L S+ +K+ADFG+ E D F GTP Y++PE++ Sbjct: 122 NGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKD 181 Query: 517 PYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYP----KSMSKEAVAIC 572 PYGK VD WA GV+LY +L G PF ED+ L+Q I +P +++ EA + Sbjct: 182 PYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLI 241 Query: 573 KGLMTKHPGKRLGCGPEGERDIKEHAFF 600 ++T +P KR+ + +H + Sbjct: 242 NKMLTINPAKRITAS-----EALKHPWI 264 >4FG9-A nrPDB Length = 320 Score = 289 bits (741), Expect = 2e-78, Method: Composition-based stats. Identities = 85/268 (31%), Positives = 141/268 (52%), Gaps = 16/268 (5%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 ++F VLG G+F +V+L+E K T +L A+K + K+ + + E +M + + K P Sbjct: 20 YDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEAL---EGKEGSMENEIAVLHKIKHP 76 Query: 402 FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKG 461 + L +++ LY +M+ V+GG+L I + G + E A ++ + +L G Sbjct: 77 NIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLG 136 Query: 462 IIYRDLKLDNVM---LDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY 518 I++RDLK +N++ LD + I I+DFG+ K G T CGTP Y+APE++A +PY Sbjct: 137 IVHRDLKPENLLYYSLDEDSKIMISDFGLSK-MEDPGSVLSTACGTPGYVAPEVLAQKPY 195 Query: 519 GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAY----PKSMSKEAVAICKG 574 K+VD W+ GV+ Y +L G PF E++ +LF+ I++ + +S A + Sbjct: 196 SKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIRH 255 Query: 575 LMTKHPGKRLGCGPEGERDIKEHAFFRY 602 LM K P KR C +H + Sbjct: 256 LMEKDPEKRFTC-----EQALQHPWIAG 278 >2JC6-A nrPDB Length = 334 Score = 288 bits (738), Expect = 4e-78, Method: Composition-based stats. Identities = 91/307 (29%), Positives = 147/307 (47%), Gaps = 19/307 (6%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 F F LG G+F +V+L+E K T +L+AVK + K + E ++ + + K Sbjct: 24 FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKAL---KGKESSIENEIAVLRKIKHE 80 Query: 402 FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKG 461 + L +++ + LY VM+ V+GG+L I + G + E A ++ +++L G Sbjct: 81 NIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMG 140 Query: 462 IIYRDLKLDNVML---DSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY 518 I++RDLK +N++ D E I I+DFG+ K G T CGTP Y+APE++A +PY Sbjct: 141 IVHRDLKPENLLYYSQDEESKIMISDFGLSK-MEGKGDVMSTACGTPGYVAPEVLAQKPY 199 Query: 519 GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAY----PKSMSKEAVAICKG 574 K+VD W+ GV+ Y +L G PF E++ +LF+ I++ + +S A + Sbjct: 200 SKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRN 259 Query: 575 LMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEF 634 LM K P KR C H + + K I + R S + + F Sbjct: 260 LMEKDPNKRYTC-----EQAARHPWIAG---DTALNKNIHESVSAQIRKNFAKSKWRQAF 311 Query: 635 TRQPVEL 641 V Sbjct: 312 NATAVVR 318 >3H4J-B nrPDB Length = 336 Score = 288 bits (738), Expect = 4e-78, Method: Composition-based stats. Identities = 78/266 (29%), Positives = 135/266 (50%), Gaps = 9/266 (3%) Query: 336 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 395 + + + LG+GSFGKV L+ T + A+K + + ++ + D E L Sbjct: 5 KRHIGPYIIRETLGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREISYLK 64 Query: 396 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 455 L + P + +L+ T + V+EY GG+L +I + R E + +I + Sbjct: 65 LL-RHPHIIKLYDVITTPTDIVMVIEYA-GGELFDYIVEKKRMTEDEGRRFFQQIICAIE 122 Query: 456 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAY 515 + I++RDLK +N++LD ++KIADFG+ + DG KT CG+P+Y APE+I Sbjct: 123 YCHRHKIVHRDLKPENLLLDDNLNVKIADFGLSN-IMTDGNFLKTSCGSPNYAAPEVING 181 Query: 516 QPY-GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKG 574 + Y G VD W+ G++LY ML G+ PF+ E LF+ + P +S A ++ + Sbjct: 182 KLYAGPEVDVWSCGIVLYVMLVGRLPFDDEFIPNLFKKVNSCVYVMPDFLSPGAQSLIRR 241 Query: 575 LMTKHPGKRLGCGPEGERDIKEHAFF 600 ++ P +R+ ++I+ +F Sbjct: 242 MIVADPMQRITI-----QEIRRDPWF 262 >3MA6-A nrPDB Length = 298 Score = 288 bits (736), Expect = 8e-78, Method: Composition-based stats. Identities = 81/275 (29%), Positives = 136/275 (49%), Gaps = 15/275 (5%) Query: 340 TDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK 399 + VLGKGSFG+V+L + K T + AVK++ K V Q D E + E ++L Sbjct: 32 DRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLD- 90 Query: 400 PPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQS 459 P + +L+ F+ Y V E GG+L I RF E A ++ G+ ++ Sbjct: 91 HPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHK 150 Query: 460 KGIIYRDLKLDNVMLDS---EGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQ 516 I++RDLK +N++L+S + +I+I DFG+ K GT YIAPE++ Sbjct: 151 NKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHF-EASKKMKDKIGTAYYIAPEVLHG- 208 Query: 517 PYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAY----PKSMSKEAVAIC 572 Y + D W+ GV+LY +L+G PF G +E ++ + + + + K +S+ A + Sbjct: 209 TYDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFELPQWKKVSESAKDLI 268 Query: 573 KGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEK 607 + ++T P R+ RD +H + + E+ Sbjct: 269 RKMLTYVPSMRISA-----RDALDHEWIQTYTKEQ 298 >2BDW-A nrPDB Length = 362 Score = 288 bits (736), Expect = 8e-78, Method: Composition-based stats. Identities = 84/297 (28%), Positives = 133/297 (44%), Gaps = 25/297 (8%) Query: 311 GQGTKAPEEKTANTISKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAV 370 GQ E N +KF +++ LGKG+F V K T +A Sbjct: 10 GQQMGRGSEFMMNASTKFS----------DNYDVKEELGKGAFSVVRRCVHKTTGLEFAA 59 Query: 371 KILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMY 430 KI+ + D + E R+ + P + +LH Q Y V + V GG+L Sbjct: 60 KIINTKKLSAR-DFQKLEREARI-CRKLQHPNIVRLHDSIQEESFHYLVFDLVTGGELFE 117 Query: 431 HIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGH---IKIADFGM 487 I + E A +I + + S GI++R+LK +N++L S+ +K+ADFG+ Sbjct: 118 DIVAREFYSEADASHCIQQILESIAYCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGL 177 Query: 488 CKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDED 547 E + D F GTP Y++PE++ PY K VD WA GV+LY +L G PF ED+ Sbjct: 178 AIE-VNDSEAWHGFAGTPGYLSPEVLKKDPYSKPVDIWACGVILYILLVGYPPFWDEDQH 236 Query: 548 ELFQSIMEHNVAYP----KSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFF 600 L+ I YP +++ EA ++ ++T +P KR+ + + Sbjct: 237 RLYAQIKAGAYDYPSPEWDTVTPEAKSLIDSMLTVNPKKRITA-----DQALKVPWI 288 >4MVF-A nrPDB Length = 506 Score = 287 bits (734), Expect = 1e-77, Method: Composition-based stats. Identities = 79/271 (29%), Positives = 138/271 (50%), Gaps = 19/271 (7%) Query: 338 KLTD-FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLAL 396 KL D + LG+G++G V K T++LYA+K KKD + ++ E ++ Sbjct: 54 KLEDKYIIDEKLGQGTYGCVYKGIDKVTNQLYAIKEEKKDRL---KNINRFFQEIEIMKK 110 Query: 397 PGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFF 456 P + +L+ ++ + +Y +ME +G +L I + G F E +A +I +F+ Sbjct: 111 LD-HPNIVKLYETYENDNYIYLIMELCSGRELFDSIIENGSFTEKNAATIMKQIFSAIFY 169 Query: 457 LQSKGIIYRDLKLDNVMLDSEGH---IKIADFGMCKENIWDGVTTKTFCGTPDYIAPEII 513 L S I++RDLK +N + SE +KI DFG+ K N+ G T T GTP Y+AP+++ Sbjct: 170 LHSLNIVHRDLKPENFLFQSENKDSLLKIIDFGLSK-NLGTGEFTTTKAGTPYYVAPQVL 228 Query: 514 AYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAY----PKSMSKEAV 569 + Y K D W+ GV++Y +L G PF G+ ++E+ + + + + S+S +A Sbjct: 229 DGK-YDKKCDIWSSGVIMYTLLCGYPPFYGDTDNEVLKKVKKGEFCFYENDWGSISSDAK 287 Query: 570 AICKGLMTKHPGKRLGCGPEGERDIKEHAFF 600 + L+T +P +R + H + Sbjct: 288 NLITKLLTYNPNERCTI-----EEALNHPWI 313 >4UZD-A nrPDB Length = 287 Score = 287 bits (734), Expect = 1e-77, Method: Composition-based stats. Identities = 81/267 (30%), Positives = 134/267 (50%), Gaps = 8/267 (2%) Query: 334 RDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRV 393 + + L DF LGKG FG V L+ K + + A+K+L K ++ VE + + Sbjct: 2 KRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFK-AQLEKAGVEHQLRREVE 60 Query: 394 LALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIG 453 + + P + +L+ F R+Y ++EY G + +Q++ +F E Y E+A Sbjct: 61 IQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANA 120 Query: 454 LFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEII 513 L + SK +I+RD+K +N++L S G +KIADFG T CGT DY+ PE+I Sbjct: 121 LSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVH--APSSRRTTLCGTLDYLPPEMI 178 Query: 514 AYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICK 573 + + + VD W+ GVL YE L G+ PFE E ++ I +P +++ A + Sbjct: 179 EGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLIS 238 Query: 574 GLMTKHPGKRLGCGPEGERDIKEHAFF 600 L+ +P +R R++ EH + Sbjct: 239 RLLKHNPSQR-----PMLREVLEHPWI 260 >2VZ6-A nrPDB Length = 313 Score = 286 bits (732), Expect = 2e-77, Method: Composition-based stats. Identities = 76/268 (28%), Positives = 124/268 (46%), Gaps = 14/268 (5%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 + LGKG+F V + + YA KI+ + D + E R+ K P Sbjct: 24 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDH-QKLEREARI-CRLLKHP 81 Query: 402 FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKG 461 + +LH Y + + V GG+L I + E A +I + G Sbjct: 82 NIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMG 141 Query: 462 IIYRDLKLDNVMLDSEGH---IKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY 518 +++RDLK +N++L S+ +K+ADFG+ E + F GTP Y++PE++ PY Sbjct: 142 VVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPY 201 Query: 519 GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYP----KSMSKEAVAICKG 574 GK VD WA GV+LY +L G PF ED+ L+Q I +P +++ EA + Sbjct: 202 GKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINK 261 Query: 575 LMTKHPGKRLGCGPEGERDIKEHAFFRY 602 ++T +P KR+ + +H + + Sbjct: 262 MLTINPSKRITAA-----EALKHPWISH 284 >2V7O-A nrPDB Length = 336 Score = 286 bits (732), Expect = 2e-77, Method: Composition-based stats. Identities = 79/267 (29%), Positives = 125/267 (46%), Gaps = 14/267 (5%) Query: 340 TDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK 399 D+ LGKG+F V +K + YA KI+ + D + E R+ K Sbjct: 31 DDYQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSARDH-QKLEREARI-CRLLK 88 Query: 400 PPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQS 459 P + +LH Y V + V GG+L I + E A +I + + Sbjct: 89 HPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQ 148 Query: 460 KGIIYRDLKLDNVMLDSEGH---IKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQ 516 I++RDLK +N++L S+ +K+ADFG+ E + F GTP Y++PE++ Sbjct: 149 HDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKD 208 Query: 517 PYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYP----KSMSKEAVAIC 572 PYGK VD WA GV+LY +L G PF ED+ +L+Q I +P +++ EA + Sbjct: 209 PYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLI 268 Query: 573 KGLMTKHPGKRLGCGPEGERDIKEHAF 599 ++T +P KR+ +H + Sbjct: 269 NQMLTINPAKRITA-----DQALKHPW 290 >5U6Y-A nrPDB Length = 461 Score = 286 bits (732), Expect = 2e-77, Method: Composition-based stats. Identities = 76/268 (28%), Positives = 124/268 (46%), Gaps = 14/268 (5%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 + LGKG+F V + + YA KI+ + D + E R+ K P Sbjct: 2 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDH-QKLEREARI-CRLLKHP 59 Query: 402 FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKG 461 + +LH Y + + V GG+L I + E A +I + G Sbjct: 60 NIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMG 119 Query: 462 IIYRDLKLDNVMLDSEGH---IKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY 518 +++RDLK +N++L S+ +K+ADFG+ E + F GTP Y++PE++ PY Sbjct: 120 VVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPY 179 Query: 519 GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYP----KSMSKEAVAICKG 574 GK VD WA GV+LY +L G PF ED+ L+Q I +P +++ EA + Sbjct: 180 GKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINK 239 Query: 575 LMTKHPGKRLGCGPEGERDIKEHAFFRY 602 ++T +P KR+ + +H + + Sbjct: 240 MLTINPSKRITAA-----EALKHPWISH 262 >3DXN-A nrPDB Length = 287 Score = 286 bits (731), Expect = 3e-77, Method: Composition-based stats. Identities = 78/268 (29%), Positives = 129/268 (48%), Gaps = 15/268 (5%) Query: 340 TDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK 399 + + LG G++G+V+L + K T A+KI+KK V + + E VL Sbjct: 21 DRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLD- 79 Query: 400 PPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQS 459 P + +L+ F+ Y VME GG+L I +F E A ++ G +L Sbjct: 80 HPNIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLSGTTYLHK 139 Query: 460 KGIIYRDLKLDNVMLDSEGH---IKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQ 516 I++RDLK +N++L+S+ IKI DFG+ + G K GT YIAPE++ + Sbjct: 140 HNIVHRDLKPENLLLESKSRDALIKIVDFGLS-AHFEVGGKMKERLGTAYYIAPEVLR-K 197 Query: 517 PYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPK----SMSKEAVAIC 572 Y + D W+ GV+LY +L G PF G+ + E+ + + + ++ +S EA + Sbjct: 198 KYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEKGKFSFDPPDWTQVSDEAKQLV 257 Query: 573 KGLMTKHPGKRLGCGPEGERDIKEHAFF 600 K ++T P KR+ + H + Sbjct: 258 KLMLTYEPSKRISA-----EEALNHPWI 280 >3HZT-A nrPDB Length = 467 Score = 285 bits (730), Expect = 4e-77, Method: Composition-based stats. Identities = 78/268 (29%), Positives = 129/268 (48%), Gaps = 15/268 (5%) Query: 340 TDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK 399 + + LG G++G+V+L + K T A+KI+KK V + + E VL Sbjct: 4 DRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLD- 62 Query: 400 PPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQS 459 P + +L+ F+ Y VME GG+L I +F E A ++ G +L Sbjct: 63 HPNIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLSGTTYLHK 122 Query: 460 KGIIYRDLKLDNVMLDSEGH---IKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQ 516 I++RDLK +N++L+S+ IKI DFG+ + G K GT YIAPE++ + Sbjct: 123 HNIVHRDLKPENLLLESKSRDALIKIVDFGLS-AHFEVGGKMKERLGTAYYIAPEVLR-K 180 Query: 517 PYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPK----SMSKEAVAIC 572 Y + D W+ GV+LY +L G PF G+ + E+ + + + ++ +S EA + Sbjct: 181 KYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEKGKFSFDPPDWTQVSDEAKQLV 240 Query: 573 KGLMTKHPGKRLGCGPEGERDIKEHAFF 600 K ++T P KR+ + H + Sbjct: 241 KLMLTYEPSKRISA-----EEALNHPWI 263 >3BHH-A nrPDB Length = 295 Score = 284 bits (727), Expect = 8e-77, Method: Composition-based stats. Identities = 76/267 (28%), Positives = 124/267 (46%), Gaps = 14/267 (5%) Query: 340 TDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK 399 ++ +GKG+F V + T YA KI+ + D + E R+ K Sbjct: 4 DEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDH-QKLEREARI-CRLLK 61 Query: 400 PPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQS 459 + +LH Y V + V GG+L I + E A +I + Sbjct: 62 HSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQ 121 Query: 460 KGIIYRDLKLDNVMLDSEGH---IKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQ 516 G+++RDLK +N++L S+ +K+ADFG+ E D F GTP Y++PE++ + Sbjct: 122 MGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKE 181 Query: 517 PYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYP----KSMSKEAVAIC 572 YGK VD WA GV+LY +L G PF ED+ +L+Q I +P +++ EA + Sbjct: 182 AYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLI 241 Query: 573 KGLMTKHPGKRLGCGPEGERDIKEHAF 599 ++T +P KR+ + +H + Sbjct: 242 NQMLTINPAKRITA-----HEALKHPW 263 >4YZB-A nrPDB Length = 491 Score = 284 bits (726), Expect = 1e-76, Method: Composition-based stats. Identities = 80/272 (29%), Positives = 133/272 (48%), Gaps = 15/272 (5%) Query: 340 TDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK 399 + VLGKGSFG+V+L + K T + YAVK++ K V Q D E + + L Sbjct: 30 DRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTDKELLLK-EVELLKKLD 88 Query: 400 PPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQS 459 P + +L+ F+ Y V E GG+L I RF E A ++ G+ ++ Sbjct: 89 HPNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHK 148 Query: 460 KGIIYRDLKLDNVMLDS---EGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQ 516 I++RDLK +N++L++ + +I+I DFG+ K GT YIAPE++ Sbjct: 149 NKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHF-ESTKKMKDKIGTAYYIAPEVLHG- 206 Query: 517 PYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAY----PKSMSKEAVAIC 572 Y + D W+ GV+LY +L+G PF G +E ++ + + + + K +S+ A + Sbjct: 207 TYDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLPQWKKVSEPAKDLI 266 Query: 573 KGLMTKHPGKRLGCGPEGERDIKEHAFFRYID 604 + ++ P R+ RD EH + + D Sbjct: 267 RKMLAYVPTMRISA-----RDALEHEWLKTTD 293 >2JAM-A nrPDB Length = 304 Score = 283 bits (725), Expect = 1e-76, Method: Composition-based stats. Identities = 91/306 (29%), Positives = 146/306 (47%), Gaps = 21/306 (6%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 F F+ VLG G+F +V L +++ T +L+A+K +KK +D +E E VL K Sbjct: 11 FIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDSSLEN---EIAVLKKI-KHE 66 Query: 402 FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKG 461 + L +++ Y VM+ V+GG+L I + G + E A ++ + +L G Sbjct: 67 NIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHENG 126 Query: 462 IIYRDLKLDNVML---DSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY 518 I++RDLK +N++ + I I DFG+ K + T CGTP Y+APE++A +PY Sbjct: 127 IVHRDLKPENLLYLTPEENSKIMITDFGLSK--MEQNGIMSTACGTPGYVAPEVLAQKPY 184 Query: 519 GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVA----YPKSMSKEAVAICKG 574 K+VD W+ GV+ Y +L G PF E E +LF+ I E + +S+ A Sbjct: 185 SKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAKDFICH 244 Query: 575 LMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEF 634 L+ K P +R C H + ID ++I P + + S + + F Sbjct: 245 LLEKDPNERYTC-----EKALSHPW---IDGNTALHRDIYPSVSLQIQKNFAKSKWRQAF 296 Query: 635 TRQPVE 640 V Sbjct: 297 NAAAVV 302 >2HAK-A nrPDB Length = 328 Score = 282 bits (721), Expect = 4e-76, Method: Composition-based stats. Identities = 94/323 (29%), Positives = 152/323 (47%), Gaps = 14/323 (4%) Query: 335 DRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVL 394 ++ + ++ +GKG+F KV L+ T AVKI+ K + ++ E R++ Sbjct: 10 EQPHIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDK-TQLNPTSLQKLFREVRIM 68 Query: 395 ALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGL 454 + P + +L +T LY VMEY +GG++ ++ GR KE A +I + Sbjct: 69 KILN-HPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAV 127 Query: 455 FFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA 514 + K I++RDLK +N++LD + +IKIADFG E G TFCG+P Y APE+ Sbjct: 128 QYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTV-GNKLDTFCGSPPYAAPELFQ 186 Query: 515 YQPYG-KSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICK 573 + Y VD W+ GV+LY +++G PF+G++ EL + ++ P MS + + K Sbjct: 187 GKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLK 246 Query: 574 GLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFDKE 633 L+ +P KR I + + E +E++P +P D DT D Sbjct: 247 KLLVLNPIKR-----GSLEQIMKDRWMN----VGHEEEELKPYTEPDP-DFNDTKRIDIM 296 Query: 634 FTRQPVELTPTDKLFIMNLDQNE 656 T D L D+ Sbjct: 297 VTMGFARDEINDALINQKYDEVM 319 >3KK8-A nrPDB Length = 284 Score = 281 bits (720), Expect = 5e-76, Method: Composition-based stats. Identities = 78/268 (29%), Positives = 126/268 (47%), Gaps = 15/268 (5%) Query: 340 TDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK 399 +++ LGKG+F V K T +A KI+ + D + E R+ + Sbjct: 6 DNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSAR-DFQKLEREARI-CRKLQ 63 Query: 400 PPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQS 459 P + +LH Q Y V + V GG+L I + E A +I + + S Sbjct: 64 HPNIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCHS 123 Query: 460 KGIIYRDLKLDNVMLDSEGH---IKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQ 516 GI++R+LK +N++L S+ +K+ADFG+ E + D F GTP Y++PE++ Sbjct: 124 NGIVHRNLKPENLLLASKAKGAAVKLADFGLAIE-VNDSEAWHGFAGTPGYLSPEVLKKD 182 Query: 517 PYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYP----KSMSKEAVAIC 572 PY K VD WA GV+LY +L G PF ED+ L+ I YP +++ EA ++ Sbjct: 183 PYSKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQIKAGAYDYPSPEWDTVTPEAKSLI 242 Query: 573 KGLMTKHPGKRLGCGPEGERDIKEHAFF 600 ++T +P KR+ + + Sbjct: 243 DSMLTVNPKKRITA-----DQALKVPWI 265 >3NCG-A nrPDB Length = 486 Score = 281 bits (720), Expect = 5e-76, Method: Composition-based stats. Identities = 77/273 (28%), Positives = 135/273 (49%), Gaps = 16/273 (5%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 +N + +LGKGSFG+V+ + + T + YAVK++ K ++ D + E +L P Sbjct: 24 YNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINK-ASAKNKDTSTILREVELLKKLD-HP 81 Query: 402 FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKG 461 + +L + Y V E GG+L I + RF E A ++ G+ ++ Sbjct: 82 NIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMHKHN 141 Query: 462 IIYRDLKLDNVMLDS---EGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY 518 I++RDLK +N++L+S + IKI DFG+ + K GT YIAPE++ Y Sbjct: 142 IVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQN-TKMKDRIGTAYYIAPEVLRG-TY 199 Query: 519 GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAY----PKSMSKEAVAICKG 574 + D W+ GV+LY +L+G PF G++E ++ + + A+ +++S +A + + Sbjct: 200 DEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRVETGKYAFDLPQWRTISDDAKDLIRK 259 Query: 575 LMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEK 607 ++T HP R+ EH + + E Sbjct: 260 MLTFHPSLRITAT-----QCLEHPWIQKYSSET 287 >3SOA-A nrPDB Length = 444 Score = 281 bits (720), Expect = 6e-76, Method: Composition-based stats. Identities = 74/270 (27%), Positives = 124/270 (45%), Gaps = 14/270 (5%) Query: 340 TDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK 399 ++ LGKG+F V + + YA I+ + D + E R+ K Sbjct: 11 EEYQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDH-QKLEREARI-CRLLK 68 Query: 400 PPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQS 459 P + +LH Y + + V GG+L I + E A +I + Sbjct: 69 HPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQ 128 Query: 460 KGIIYRDLKLDNVMLDSEGH---IKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQ 516 G+++R+LK +N++L S+ +K+ADFG+ E + F GTP Y++PE++ Sbjct: 129 MGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKD 188 Query: 517 PYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYP----KSMSKEAVAIC 572 PYGK VD WA GV+LY +L G PF ED+ L+Q I +P +++ EA + Sbjct: 189 PYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLI 248 Query: 573 KGLMTKHPGKRLGCGPEGERDIKEHAFFRY 602 ++T +P KR+ + +H + + Sbjct: 249 NKMLTINPSKRITAA-----EALKHPWISH 273 >3LIJ-A nrPDB Length = 494 Score = 281 bits (719), Expect = 7e-76, Method: Composition-based stats. Identities = 72/269 (26%), Positives = 133/269 (49%), Gaps = 16/269 (5%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 + + LG G++G+V+L K T A+KI++K V + + ++E+ + P Sbjct: 39 YQRVKKLGSGAYGEVLLCRDKVTHVERAIKIIRKTSVSTSSNSK--LLEEVAVLKLLDHP 96 Query: 402 FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKG 461 + +L+ F+ Y VME GG+L I +F E A ++ G+ +L Sbjct: 97 NIMKLYDFFEDKRNYYLVMECYKGGELFDEIIHRMKFNEVDAAVIIKQVLSGVTYLHKHN 156 Query: 462 IIYRDLKLDNVMLDS---EGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY 518 I++RDLK +N++L+S + IKI DFG+ + K GT YIAPE++ + Y Sbjct: 157 IVHRDLKPENLLLESKEKDALIKIVDFGLS-AVFENQKKMKERLGTAYYIAPEVLR-KKY 214 Query: 519 GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAY----PKSMSKEAVAICKG 574 + D W+ GV+L+ +LAG PF G+ + E+ + + + + K++S+ A + K Sbjct: 215 DEKCDVWSIGVILFILLAGYPPFGGQTDQEILRKVEKGKYTFDSPEWKNVSEGAKDLIKQ 274 Query: 575 LMTKHPGKRLGCGPEGERDIKEHAFFRYI 603 ++ +R+ + EH + + + Sbjct: 275 MLQFDSQRRISA-----QQALEHPWIKEM 298 >4CQG-A nrPDB Length = 331 Score = 281 bits (718), Expect = 1e-75, Method: Composition-based stats. Identities = 70/260 (26%), Positives = 126/260 (48%), Gaps = 10/260 (3%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 + +G G F KV L+ T E+ A+KI+ K+ + D+ E L + Sbjct: 11 YELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGS--DLPRVKTEIDALK-SLRHQ 67 Query: 402 FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKG 461 + QL+ +T ++++ V+EY GG+L +I R E +I + ++ S+G Sbjct: 68 HICQLYHVLETKNKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQILSAVAYVHSQG 127 Query: 462 IIYRDLKLDNVMLDSEGHIKIADFGM-CKENIWDGVTTKTFCGTPDYIAPEIIAYQPY-G 519 +RDLK +N++ D +K+ DFG+ K + CG+ Y APE+I + Y G Sbjct: 128 YAHRDLKPENLLFDENHKLKLIDFGLCAKPKGNKDYHLQECCGSLAYAAPELIQGKSYLG 187 Query: 520 KSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKH 579 D W+ G+LLY ++ G PF+ ++ L++ IM PK +S ++ + + ++ Sbjct: 188 SEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYEVPKWLSPSSILLLQQMLQVD 247 Query: 580 PGKRLGCGPEGERDIKEHAF 599 P KR+ R++ H + Sbjct: 248 PKKRISM-----RNLLNHPW 262 >5IG1-A nrPDB Length = 344 Score = 280 bits (717), Expect = 1e-75, Method: Composition-based stats. Identities = 79/265 (29%), Positives = 125/265 (47%), Gaps = 15/265 (5%) Query: 347 VLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQL 406 V+GKG+F V K T E+ AVK++ ++ ++ E + + + + Sbjct: 24 VIGKGAFSTVHRCVNKRTGEVCAVKVIALKS-LRSSEINKIKREIGI-CSSLQHEHIVSM 81 Query: 407 HSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRD 466 F+ Y V EYV+GG+L I + E A +I L SK II+RD Sbjct: 82 RRAFRDESHFYLVFEYVSGGELFDEIVTRKFYNEKDASACMHQILSALQHCHSKNIIHRD 141 Query: 467 LKLDNVML---DSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVD 523 LK +N++L D +KI DFG+ + G T F GTP Y++PE+I PY +VD Sbjct: 142 LKPENLLLASKDPNAPVKITDFGLAV-IMEQGPTYFGFAGTPGYLSPEVIRRVPYDTAVD 200 Query: 524 WWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYP----KSMSKEAVAICKGLMTKH 579 WA GV+LY +L G PF ED +L+ I +P S++ A + K ++ + Sbjct: 201 VWACGVILYILLVGYPPFWEEDHQKLYAQIKNCQYDFPSPEWDSVTTAAKELIKAMLEPN 260 Query: 580 PGKRLGCGPEGERDIKEHAFFRYID 604 P +R +++ +H + D Sbjct: 261 PKRRPT-----VQELLQHPWIARRD 280 >4RGJ-A nrPDB Length = 520 Score = 280 bits (717), Expect = 1e-75, Method: Composition-based stats. Identities = 84/315 (26%), Positives = 147/315 (46%), Gaps = 19/315 (6%) Query: 296 EGNEELRQKFERAKIGQGTKAPEEKTANTISKFDNNGNRDRMKLTD-FNFLMVLGKGSFG 354 GNE R + + + +G K E N+ + + + + + +LGKGSFG Sbjct: 17 GGNE--RHEMKESSVGISKKIVENSFNNSKLRPGMFIQNSNVVFNEQYKGIKILGKGSFG 74 Query: 355 KVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMD 414 +V+LS K T YA+K++ K V + D E + E +L + + +L+ F+ + Sbjct: 75 EVILSRDKHTGHEYAIKVISKKHVKRKTDKESLLREVELLKMLDHINIM-KLYEFFEDNN 133 Query: 415 RLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVML 474 Y V + GG+L I RF E A +I G+ ++ +++RDLK +N++L Sbjct: 134 YYYLVSDVYTGGELFDEIISRKRFYEIDAARIIKQILSGITYMHKNNVVHRDLKPENILL 193 Query: 475 D----SEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVL 530 + + IKI DFG+ + K GT YIAP+++ Y + D W+ GV+ Sbjct: 194 ETKNKEDMIIKIIDFGLSTHFEY-SKKMKDKIGTAYYIAPDVLHG-TYDEKCDIWSCGVI 251 Query: 531 LYEMLAGQAPFEGEDEDELFQSIMEHNVAYP----KSMSKEAVAICKGLMTKHPGKRLGC 586 LY +L+G PF G +E ++ + + + K +S +A + K ++ R+ Sbjct: 252 LYILLSGCPPFNGSNEYDILKKVEAGKYTFDLPQFKKISDKAKDLIKKMLMYTSAVRISA 311 Query: 587 GPEGERDIKEHAFFR 601 RD EH + + Sbjct: 312 -----RDALEHEWIK 321 >4FR4-A nrPDB Length = 384 Score = 279 bits (715), Expect = 2e-75, Method: Composition-based stats. Identities = 96/325 (29%), Positives = 165/325 (50%), Gaps = 19/325 (5%) Query: 323 NTISKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDD 382 + FD N + + F L +GKGSFGKV + ++ T ++YA+K + K ++ + Sbjct: 1 SMPPVFDEN---EDVNFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERN 57 Query: 383 DVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPH 442 +V E +++ + PFL L FQ + ++ V++ + GGDL YH+QQ FKE Sbjct: 58 EVRNVFKELQIMQ-GLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEET 116 Query: 443 AVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFC 502 + E+ + L +LQ++ II+RD+K DN++LD GH+ I DF + + T Sbjct: 117 VKLFICELVMALDYLQNQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRE-TQITTMA 175 Query: 503 GTPDYIAPEIIAYQP---YGKSVDWWAFGVLLYEMLAGQAPFE---GEDEDELFQSIMEH 556 GT Y+APE+ + + Y +VDWW+ GV YE+L G+ P+ E+ + Sbjct: 176 GTKPYMAPEMFSSRKGAGYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHTFETT 235 Query: 557 NVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPP 616 V YP + S+E V++ K L+ +P +R D++ + I+W+ + +K + P Sbjct: 236 VVTYPSAWSQEMVSLLKKLLEPNPDQRFS----QLSDVQNFPYMNDINWDAVFQKRLIPG 291 Query: 617 YKPKARDKRDTSNFDKEFTRQPVEL 641 + P + N D F + + L Sbjct: 292 FIPN----KGRLNCDPTFELEEMIL 312 >5YKS-A nrPDB Length = 377 Score = 279 bits (715), Expect = 2e-75, Method: Composition-based stats. Identities = 73/266 (27%), Positives = 127/266 (47%), Gaps = 11/266 (4%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 ++ LG+G F V L+ T E AVK++ K + E R + L + P Sbjct: 37 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTK-LDTLATGHLFQEVRCMKLV-QHP 94 Query: 402 FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR-FKEPHAVFYAAEIAIGLFFLQSK 460 + +L+ T +LY ++E +GGD+ +I + E A Y A+I + + Sbjct: 95 NIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKL 154 Query: 461 GIIYRDLKLDNV-MLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYG 519 +++RDLK +NV + +G +K+ DFG + G T CG+ Y APEI+ Y Sbjct: 155 HVVHRDLKPENVVFFEKQGLVKLTDFGFSNKF-QPGKKLTTSCGSLAYSAPEILLGDEYD 213 Query: 520 -KSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTK 578 +VD W+ GV+L+ ++ GQ PF+ ++ E IM+ P +SKE + ++ + Sbjct: 214 APAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITRMLQR 273 Query: 579 HPGKRLGCGPEGERDIKEHAFFRYID 604 P +R +I+ H + + +D Sbjct: 274 DPKRRASL-----EEIENHPWLQGVD 294 >3DFA-A nrPDB Length = 286 Score = 279 bits (714), Expect = 3e-75, Method: Composition-based stats. Identities = 76/268 (28%), Positives = 134/268 (50%), Gaps = 16/268 (5%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 +N + +LGKGSFG+V+ + + T + YAVK++ K ++ D + E +L P Sbjct: 24 YNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINK-ASAKNKDTSTILREVELLKKLD-HP 81 Query: 402 FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKG 461 + +L + Y V E GG+L I + RF E A ++ G+ ++ Sbjct: 82 NIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMHKHN 141 Query: 462 IIYRDLKLDNVMLDS---EGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY 518 I++RDLK +N++L+S + IKI DFG+ + K GT YIAPE++ Y Sbjct: 142 IVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQN-TKMKDRIGTAYYIAPEVLRG-TY 199 Query: 519 GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAY----PKSMSKEAVAICKG 574 + D W+ GV+LY +L+G PF G++E ++ + + A+ +++S +A + + Sbjct: 200 DEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRVETGKYAFDLPQWRTISDDAKDLIRK 259 Query: 575 LMTKHPGKRLGCGPEGERDIKEHAFFRY 602 ++T HP R+ EH + + Sbjct: 260 MLTFHPSLRITAT-----QCLEHPWIQK 282 >6C9D-A nrPDB Length = 459 Score = 279 bits (713), Expect = 3e-75, Method: Composition-based stats. Identities = 96/336 (28%), Positives = 155/336 (46%), Gaps = 16/336 (4%) Query: 335 DRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVL 394 ++ + ++ +GKG+F KV L+ T AVKI+ K + ++ E R++ Sbjct: 16 EQPHIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDK-TQLNPTSLQKLFREVRIM 74 Query: 395 ALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGL 454 + P + +L +T LY VMEY +GG++ ++ GR KE A +I + Sbjct: 75 KILN-HPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAV 133 Query: 455 FFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA 514 + K I++RDLK +N++LD + +IKIADFG E G FCG+P Y APE+ Sbjct: 134 QYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTV-GNKLDEFCGSPPYAAPELFQ 192 Query: 515 YQPYG-KSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICK 573 + Y VD W+ GV+LY +++G PF+G++ EL + ++ P MS + + K Sbjct: 193 GKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLK 252 Query: 574 GLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFDKE 633 L+ +P KR I + + E +E++P +P D DT D Sbjct: 253 KLLVLNPIKR-----GSLEQIMKDRWMN----VGHEEEELKPYTEPDP-DFNDTKRIDIM 302 Query: 634 FTRQPVELTPTDKLFIMNLDQNE--FAGFSYTNPEF 667 T D L D+ + PEF Sbjct: 303 VTMGFARDEINDALINQKYDEVMATYILLGRKPPEF 338 >2W4O-A nrPDB Length = 349 Score = 278 bits (711), Expect = 6e-75, Method: Composition-based stats. Identities = 90/313 (28%), Positives = 144/313 (46%), Gaps = 20/313 (6%) Query: 295 SEGNEELRQKFERAKIGQGTKAPEEKTANTISKFDNNGNRDRMKLTDFNFLMVLGKGSFG 354 S G + + + T + TA+ + + +G+ F LG+G+ Sbjct: 8 SSGVDLGTENLYFQSMSSVTASAAPGTASLVPDYWIDGSNRDALSDFFEVESELGRGATS 67 Query: 355 KVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMD 414 V ++KGT + YA+K+LKK V D + E VL P + +L F+T Sbjct: 68 IVYRCKQKGTQKPYALKVLKKTV-----DKKIVRTEIGVLLRLS-HPNIIKLKEIFETPT 121 Query: 415 RLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVML 474 + V+E V GG+L I + G + E A +I + +L GI++RDLK +N++ Sbjct: 122 EISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLY 181 Query: 475 DS---EGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLL 531 + + +KIADFG+ K + V KT CGTP Y APEI+ YG VD W+ G++ Sbjct: 182 ATPAPDAPLKIADFGLSK-IVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIIT 240 Query: 532 YEMLAGQAPFEGEDEDE-LFQSIMEHNVAY----PKSMSKEAVAICKGLMTKHPGKRLGC 586 Y +L G PF E D+ +F+ I+ + +S A + + L+ P KRL Sbjct: 241 YILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVRKLIVLDPKKRLTT 300 Query: 587 GPEGERDIKEHAF 599 +H + Sbjct: 301 F-----QALQHPW 308 >4YNZ-A nrPDB Length = 342 Score = 277 bits (709), Expect = 9e-75, Method: Composition-based stats. Identities = 79/293 (26%), Positives = 142/293 (48%), Gaps = 11/293 (3%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 + LGKG G V L T + A+KI+ ++ + + + E +L L + P Sbjct: 12 YRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREK-LSESVLMKVEREIAILKLI-EHP 69 Query: 402 FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKG 461 + +LH ++ LY V+E+V+GG+L ++ + GR A + +I L F S Sbjct: 70 HVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHS 129 Query: 462 IIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYG-K 520 I +RDLK +N++LD +I+IADFGM + D + +T CG+P Y PE+I + Y + Sbjct: 130 ICHRDLKPENLLLDERNNIRIADFGMASLQVGDSL-LETSCGSPHYACPEVIRGEKYDGR 188 Query: 521 SVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHP 580 D W+ GV+L+ +L G PF+ ++ +L + + P + + ++ +G++ Sbjct: 189 KADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVDA 248 Query: 581 GKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFDKE 633 +RL I++H ++ I + E P K + R + D + Sbjct: 249 ARRLTL-----EHIQKHIWY--IGGKNEPEPEQPIPRKVQIRSLPSLEDIDPD 294 >4JG6-A nrPDB Length = 355 Score = 277 bits (709), Expect = 1e-74, Method: Composition-based stats. Identities = 80/330 (24%), Positives = 141/330 (42%), Gaps = 26/330 (7%) Query: 333 NRDRMKLTD-FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEK 391 +R+ ++ TD + +G GS+ K T+ +AVKI+ K E Sbjct: 27 HRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSK-------RDPTEEI 79 Query: 392 RVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIA 451 +L G+ P + L + +Y V E + GG+L+ I + F E A I Sbjct: 80 EILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTIT 139 Query: 452 IGLFFLQSKGIIYRDLKLDNVM-LDSEGH---IKIADFGMCKENIWDGVTTKTFCGTPDY 507 + +L ++G+++RDLK N++ +D G+ I+I DFG K+ + T C T ++ Sbjct: 140 KTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANF 199 Query: 508 IAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPF---EGEDEDELFQSIMEHNVA----Y 560 +APE++ Q Y + D W+ GVLLY ML G PF + +E+ I + Y Sbjct: 200 VAPEVLERQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGY 259 Query: 561 PKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPK 620 S+S A + ++ P +RL + H + + W++L + ++ P Sbjct: 260 WNSVSDTAKDLVSKMLHVDPHQRLTAAL-----VLRHPWI--VHWDQLPQYQLNRQDAPH 312 Query: 621 ARDKRDTSNFDKEFTRQPVELTPTDKLFIM 650 + + Q L P + + Sbjct: 313 LVKGAMAATYSALNRNQSPVLEPVGRSTLA 342 >4I6B-A nrPDB Length = 308 Score = 277 bits (708), Expect = 1e-74, Method: Composition-based stats. Identities = 73/259 (28%), Positives = 122/259 (47%), Gaps = 6/259 (2%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 ++ LGKG F K +++YA KI+ V + E E L Sbjct: 30 YSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKIDKEIE-LHRILHHK 88 Query: 402 FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKG 461 + Q + F+ + +Y ++EY + + + ++ EP +Y +I GL +L + Sbjct: 89 HVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQE 148 Query: 462 IIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKS 521 I++RDLKL N ++ +K+ DFG+ +T CGTP+Y++PE++ Q +G Sbjct: 149 ILHRDLKLGNFFINESMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGAE 208 Query: 522 VDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPG 581 D WA G ++Y ML G+ PFE + E ++SI E P S+ A + +++K+P Sbjct: 209 SDIWALGCVMYTMLLGRPPFETTNLKETYRSIREARYTMPSSLLAPAKHLIASMLSKNPE 268 Query: 582 KRLGCGPEGERDIKEHAFF 600 R DI H FF Sbjct: 269 DRPSL-----DDIIRHDFF 282 >4D2V-A nrPDB Length = 356 Score = 276 bits (707), Expect = 2e-74, Method: Composition-based stats. Identities = 71/279 (25%), Positives = 128/279 (45%), Gaps = 11/279 (3%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 + +G G F KV L+ T E+ A+KI+ K+ + D+ E L + Sbjct: 31 YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGS--DLPRIKTEIEALK-NLRHQ 87 Query: 402 FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKG 461 + QL+ +T ++++ V+EY GG+L +I R E +I + ++ S+G Sbjct: 88 HICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQG 147 Query: 462 IIYRDLKLDNVMLDSEGHIKIADFGM-CKENIWDGVTTKTFCGTPDYIAPEIIAYQPY-G 519 +RDLK +N++ D +K+ DFG+ K + CG Y APE+I + Y G Sbjct: 148 YAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQACCGALAYAAPELIQGKSYLG 207 Query: 520 KSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKH 579 D W+ G+LLY ++ G PF+ + L IM PK +S ++ + + ++ Sbjct: 208 SEADVWSMGILLYVLMCGFLPFDDDTAAALVAKIMRGKYDVPKWLSPSSILLLQQMLQVD 267 Query: 580 PGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYK 618 P KR+ +++ H + D+ + + P+ Sbjct: 268 PKKRISM-----KNLLNHPWIMQ-DYNYPVEWQSKNPFI 300 >5WAX-A nrPDB Length = 310 Score = 276 bits (705), Expect = 3e-74, Method: Composition-based stats. Identities = 77/270 (28%), Positives = 126/270 (46%), Gaps = 20/270 (7%) Query: 340 TDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK 399 + + +G G+FG L + +L AVK +++ + ++ + + + + Sbjct: 11 DRYELVRDIGSGNFGVARLMRNRADGQLVAVKYIERG-----EKIDENVQREIINHRSLR 65 Query: 400 PPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQS 459 P + + T L VMEY +GG+L I GRF E A F+ ++ G+ + S Sbjct: 66 HPNIIRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHS 125 Query: 460 KGIIYRDLKLDNVMLDSEG--HIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQP 517 + +RDLKL+N +LD +KI DFG K ++ K+ GTP YIAPE++ + Sbjct: 126 MQVCHRDLKLENTLLDGSTAPRLKICDFGYSKSSVLHS-QPKSTVGTPAYIAPEVLLKKE 184 Query: 518 YGKSV-DWWAFGVLLYEMLAGQAPFEGEDEDELFQS----IMEHNVAYPK--SMSKEAVA 570 Y V D W+ GV LY ML G PFE DE + F+ I+ + P +S E Sbjct: 185 YDGKVADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRILGVQYSIPDYVHISPECQD 244 Query: 571 ICKGLMTKHPGKRLGCGPEGERDIKEHAFF 600 + + +P R+ +I+ H +F Sbjct: 245 LISRIFVANPATRITI-----PEIRNHPWF 269 >4NIF-A nrPDB Length = 333 Score = 272 bits (697), Expect = 3e-73, Method: Composition-based stats. Identities = 70/271 (25%), Positives = 123/271 (45%), Gaps = 23/271 (8%) Query: 340 TDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK 399 + +G GS+ + K T+ YAVK++ K + E +L G+ Sbjct: 8 DGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSE-------EIEILLRYGQ 60 Query: 400 PPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQS 459 P + L + +Y V E + GG+L+ I + F E A F I + +L S Sbjct: 61 HPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHS 120 Query: 460 KGIIYRDLKLDNVM-LDSEGH---IKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAY 515 +G+++RDLK N++ +D G+ ++I DFG K+ + T C T +++APE++ Sbjct: 121 QGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKR 180 Query: 516 QPYGKSVDWWAFGVLLYEMLAGQAPF---EGEDEDELFQSIMEHNVAY----PKSMSKEA 568 Q Y + D W+ G+LLY MLAG PF + +E+ I ++S+ A Sbjct: 181 QGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETA 240 Query: 569 VAICKGLMTKHPGKRLGCGPEGERDIKEHAF 599 + ++ P +RL + + +H + Sbjct: 241 KDLVSKMLHVDPHQRLTA-----KQVLQHPW 266 >4B6L-A nrPDB Length = 281 Score = 272 bits (696), Expect = 3e-73, Method: Composition-based stats. Identities = 72/259 (27%), Positives = 117/259 (45%), Gaps = 6/259 (2%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 + +LGKG F + + T YAVK++ + V + E + E L + Sbjct: 11 YLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIE-LHRDLQHR 69 Query: 402 FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKG 461 + + F+ D +Y +E + L + + EP +Y +I GL +L +G Sbjct: 70 HIVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRG 129 Query: 462 IIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKS 521 I++RDLKL N + +K+ DFG+ KT CGTP+Y+APE++ Q +G Sbjct: 130 ILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPE 189 Query: 522 VDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPG 581 D W+ G ++Y +L G PFE D E ++ I + + P S+S A + ++ P Sbjct: 190 ADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPR 249 Query: 582 KRLGCGPEGERDIKEHAFF 600 R I H FF Sbjct: 250 DRPSI-----DQILRHDFF 263 >2J90-A nrPDB Length = 304 Score = 271 bits (693), Expect = 7e-73, Method: Composition-based stats. Identities = 81/278 (29%), Positives = 130/278 (46%), Gaps = 18/278 (6%) Query: 337 MKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDD---VECTMVEKRV 393 M + LG G F V +KGT + YA K +KK + E E + Sbjct: 23 MVEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNI 82 Query: 394 LALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIG 453 L + P + LH F+ + ++E V+GG+L + + E A + +I G Sbjct: 83 L-REIRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDG 141 Query: 454 LFFLQSKGIIYRDLKLDNVMLDSEG----HIKIADFGMCKENIWDGVTTKTFCGTPDYIA 509 + +L SK I + DLK +N+ML + IK+ DFG+ I G K GTP+++A Sbjct: 142 VHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIA-HKIEAGNEFKNIFGTPEFVA 200 Query: 510 PEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPK----SMS 565 PEI+ Y+P G D W+ GV+ Y +L+G +PF GE + E +I N + + + S Sbjct: 201 PEIVNYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYFSNTS 260 Query: 566 KEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYI 603 + A + L+ K P +R+ EH++ + I Sbjct: 261 ELAKDFIRRLLVKDPKRRMTIAQS-----LEHSWIKAI 293 >4CSV-A nrPDB Length = 275 Score = 271 bits (692), Expect = 1e-72, Method: Composition-based stats. Identities = 66/258 (25%), Positives = 120/258 (46%), Gaps = 10/258 (3%) Query: 333 NRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKR 392 ++ + ++ LG G FG+V + + + AVK LK+ + VE + E + Sbjct: 4 DKWEIPRSEITLERKLGSGQFGEVYEGKWRNYNIEVAVKTLKEGTMS----VEEFLQEAQ 59 Query: 393 VLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVG--RFKEPHAVFYAAEI 450 ++ K P L QL+ +Y + EY++ G L+ +++ + AA++ Sbjct: 60 IMKKL-KHPNLVQLYGVCTKEPPIYIITEYMSHGSLLDYLRDCEGHTVNAQALLDMAAQV 118 Query: 451 AIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTP-DYIA 509 A G+ +L+S+ I+RDL N ++ +K+ADFG+ + D T + P + A Sbjct: 119 ASGMAYLESQNFIHRDLAARNCLVGENNVVKVADFGLARLINEDEYTARAGAKFPIKWTA 178 Query: 510 PEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIMEH-NVAYPKSMSKE 567 PE I+Y + D WAFG+LL+E+ GQ P+ G E+ + + + P+ +E Sbjct: 179 PEAISYNRFSIKSDVWAFGILLWEIFTYGQVPYPGMSGSEVIEQVERGYRMPRPQGCPEE 238 Query: 568 AVAICKGLMTKHPGKRLG 585 + K P +R Sbjct: 239 IYELMLQCWNKSPEERPT 256 >3UC3-A nrPDB Length = 361 Score = 271 bits (692), Expect = 1e-72, Method: Composition-based stats. Identities = 82/270 (30%), Positives = 126/270 (46%), Gaps = 20/270 (7%) Query: 340 TDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK 399 ++F+ +G G+FG L K T EL AVK +++ I ++ + + + + Sbjct: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGAAIDEN-----VQREIINHRSLR 74 Query: 400 PPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQS 459 P + + T L +MEY +GG+L I GRF E A F+ ++ G+ + S Sbjct: 75 HPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHS 134 Query: 460 KGIIYRDLKLDNVMLDSE--GHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQP 517 I +RDLKL+N +LD +KI DFG K ++ K+ GTP YIAPE++ Q Sbjct: 135 MQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHS-QPKSTVGTPAYIAPEVLLRQE 193 Query: 518 YGKS-VDWWAFGVLLYEMLAGQAPFEG----EDEDELFQSIMEHNVAYPKS--MSKEAVA 570 Y D W+ GV LY ML G PFE D + Q I+ + P +S E Sbjct: 194 YDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCH 253 Query: 571 ICKGLMTKHPGKRLGCGPEGERDIKEHAFF 600 + + P R+ +IK H++F Sbjct: 254 LISRIFVADPATRISI-----PEIKTHSWF 278 >2OU7-A nrPDB Length = 335 Score = 271 bits (692), Expect = 1e-72, Method: Composition-based stats. Identities = 80/307 (26%), Positives = 141/307 (45%), Gaps = 20/307 (6%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 407 LGKG F K T E++A KI+ K ++++ E +E + + H Sbjct: 49 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLA-HQHVVGFH 107 Query: 408 SCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDL 467 F+ D ++ V+E L+ ++ EP A +Y +I +G +L +I+RDL Sbjct: 108 GFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDL 167 Query: 468 KLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAF 527 KL N+ L+ + +KI DFG+ + +DG K CGTP+YIAPE+++ + + VD W+ Sbjct: 168 KLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGHSFEVDVWSI 227 Query: 528 GVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCG 587 G ++Y +L G+ PFE E + I ++ + PK ++ A ++ + ++ P R Sbjct: 228 GCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTI- 286 Query: 588 PEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEFTRQPVELTPTDKL 647 ++ FF Y P AR F+ P L P+++ Sbjct: 287 ----NELLNDEFF-------------TSGYIP-ARLPITCLTIPPRFSIAPSSLDPSNRK 328 Query: 648 FIMNLDQ 654 + L++ Sbjct: 329 PLTVLNK 335 >4B8L-A nrPDB Length = 286 Score = 270 bits (691), Expect = 1e-72, Method: Composition-based stats. Identities = 76/268 (28%), Positives = 139/268 (51%), Gaps = 8/268 (2%) Query: 334 RDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRV 393 + + + DF+ LGKG FG V L+ K + A+K+L K ++ + VE + + Sbjct: 9 KRKFTIDDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQ-LEKEGVEHQLRREIE 67 Query: 394 LALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIG 453 + + P + ++++ F R+Y ++E+ G+L +Q+ GRF E + + E+A Sbjct: 68 IQSHLRHPNILRMYNYFHDRKRIYLMLEFAPRGELYKELQKHGRFDEQRSATFMEELADA 127 Query: 454 LFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEII 513 L + + +I+RD+K +N+++ +G +KIADFG + +T CGT DY+ PE+I Sbjct: 128 LHYCHERKVIHRDIKPENLLMGYKGELKIADFGWSVH--APSLRRRTMCGTLDYLPPEMI 185 Query: 514 AYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICK 573 + + + VD W GVL YE L G PF+ E + I+ ++ +P +S + + Sbjct: 186 EGKTHDEKVDLWCAGVLCYEFLVGMPPFDSPSHTETHRRIVNVDLKFPPFLSDGSKDLIS 245 Query: 574 GLMTKHPGKRLGCGPEGERDIKEHAFFR 601 L+ HP +RL + + EH + + Sbjct: 246 KLLRYHPPQRLPL-----KGVMEHPWVK 268 >2A27-A nrPDB Length = 321 Score = 270 bits (690), Expect = 2e-72, Method: Composition-based stats. Identities = 88/321 (27%), Positives = 145/321 (45%), Gaps = 28/321 (8%) Query: 336 RMKLTDF-NFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDD---VECTMVEK 391 + K+ DF + LG G F V K T YA K +KK E E Sbjct: 7 QQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREV 66 Query: 392 RVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIA 451 +L +T LH ++ + ++E V+GG+L + Q E A + +I Sbjct: 67 SILRQVLHHNVIT-LHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQIL 125 Query: 452 IGLFFLQSKGIIYRDLKLDNVMLDSEG----HIKIADFGMCKENIWDGVTTKTFCGTPDY 507 G+ +L +K I + DLK +N+ML + HIK+ DFG+ E I DGV K GTP++ Sbjct: 126 DGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHE-IEDGVEFKNIFGTPEF 184 Query: 508 IAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSM--- 564 +APEI+ Y+P G D W+ GV+ Y +L+G +PF G+ + E +I + + + Sbjct: 185 VAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQ 244 Query: 565 -SKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARD 623 S+ A + L+ K KRL ++ H + +D ++ + Sbjct: 245 TSELAKDFIRKLLVKETRKRLTI-----QEALRHPWITPVDNQQAMVRR---------ES 290 Query: 624 KRDTSNFDKEFTRQPVELTPT 644 + NF K++ R+ +L + Sbjct: 291 VVNLENFRKQYVRRRSKLAFS 311 >4J52-A nrPDB Length = 293 Score = 269 bits (689), Expect = 2e-72, Method: Composition-based stats. Identities = 71/253 (28%), Positives = 125/253 (49%), Gaps = 6/253 (2%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 407 LGKG F K T E++A KI+ K ++++ E +E + + H Sbjct: 22 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLA-HQHVVGFH 80 Query: 408 SCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDL 467 F+ D ++ V+E L+ ++ EP A +Y +I +G +L +I+RDL Sbjct: 81 GFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDL 140 Query: 468 KLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAF 527 KL N+ L+ + +KI DFG+ + +DG K CGTP+YIAPE+++ + + VD W+ Sbjct: 141 KLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGHSFEVDVWSI 200 Query: 528 GVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCG 587 G ++Y +L G+ PFE E + I ++ + PK ++ A ++ + ++ P R Sbjct: 201 GCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTI- 259 Query: 588 PEGERDIKEHAFF 600 ++ FF Sbjct: 260 ----NELLNDEFF 268 >2YAB-A nrPDB Length = 361 Score = 269 bits (688), Expect = 3e-72, Method: Composition-based stats. Identities = 88/321 (27%), Positives = 146/321 (45%), Gaps = 28/321 (8%) Query: 336 RMKLTDF-NFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDD---VECTMVEK 391 + K+ DF + LG G F V K T YA K +KK E E Sbjct: 7 QQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIEREV 66 Query: 392 RVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIA 451 +L P + LH ++ + ++E V+GG+L + Q E A + +I Sbjct: 67 SILRQVL-HPNIITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQIL 125 Query: 452 IGLFFLQSKGIIYRDLKLDNVMLDSEG----HIKIADFGMCKENIWDGVTTKTFCGTPDY 507 G+ +L +K I + DLK +N+ML + HIK+ DFG+ E I DGV K GTP++ Sbjct: 126 DGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHE-IEDGVEFKNIFGTPEF 184 Query: 508 IAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSM--- 564 +APEI+ Y+P G D W+ GV+ Y +L+G +PF G+ + E +I + + + Sbjct: 185 VAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQ 244 Query: 565 -SKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARD 623 S+ A + L+ K KRL ++ H + +D ++ + Sbjct: 245 TSELAKDFIRKLLVKETRKRLTI-----QEALRHPWITPVDTQQAMVRR---------ES 290 Query: 624 KRDTSNFDKEFTRQPVELTPT 644 + NF K++ R+ +L+ + Sbjct: 291 VVNLENFKKQYVRRRWKLSFS 311 >3DB8-A nrPDB Length = 317 Score = 269 bits (687), Expect = 4e-72, Method: Composition-based stats. Identities = 72/266 (27%), Positives = 127/266 (47%), Gaps = 6/266 (2%) Query: 335 DRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVL 394 D + + LGKG F K T E++A K++ K ++++ E E + Sbjct: 37 DPRTMKRYMRGRFLGKGGFAKCYEITDMDTKEVFAGKVVPKSMLLKPHQKEKMSTEIAIH 96 Query: 395 ALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGL 454 P + H F+ D +Y V+E L+ ++ EP A ++ + G+ Sbjct: 97 KSLDN-PHVVGFHGFFEDDDFVYVVLEICRRRSLLELHKRRKAVTEPEARYFMRQTIQGV 155 Query: 455 FFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA 514 +L + +I+RDLKL N+ L+ + +KI DFG+ + +DG K CGTP+YIAPE++ Sbjct: 156 QYLHNNRVIHRDLKLGNLFLNDDMDVKIGDFGLATKIEFDGERKKDLCGTPNYIAPEVLC 215 Query: 515 YQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKG 574 + + VD W+ G +LY +L G+ PFE E + I ++ + P+ ++ A A+ + Sbjct: 216 KKGHSFEVDIWSLGCILYTLLVGKPPFETSCLKETYIRIKKNEYSVPRHINPVASALIRR 275 Query: 575 LMTKHPGKRLGCGPEGERDIKEHAFF 600 ++ P R ++ FF Sbjct: 276 MLHADPTLRPSVA-----ELLTDEFF 296 >3I6U-A nrPDB Length = 419 Score = 269 bits (687), Expect = 4e-72, Method: Composition-based stats. Identities = 84/332 (25%), Positives = 144/332 (43%), Gaps = 29/332 (8%) Query: 294 GSEGNEELRQKFERAKIGQGTKAPEEKTANTISKF-----DNNGNRDRMKLTDFNFLMVL 348 G+ N EL K +R + ++ + N + F D+ + ++ L Sbjct: 84 GTFVNTELVGKGKRRPLNNNSEIALSLSRNKVFVFFDLTVDDQSVYPKALRDEYIMSKTL 143 Query: 349 GKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVE-----CTMVEKRVLALPGKPPFL 403 G G+ G+V L+ + T + A++I+ K E E +L P + Sbjct: 144 GSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSAREADPALNVETEIEILKKLN-HPCI 202 Query: 404 TQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGII 463 ++ + F D Y V+E + GG+L + R KE Y ++ + + +L GII Sbjct: 203 IKIKNFFDAEDY-YIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGII 261 Query: 464 YRDLKLDNVMLD---SEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEII---AYQP 517 +RDLK +NV+L + IKI DFG K + + +T CGTP Y+APE++ Sbjct: 262 HRDLKPENVLLSSQEEDCLIKITDFGHSK-ILGETSLMRTLCGTPTYLAPEVLVSVGTAG 320 Query: 518 YGKSVDWWAFGVLLYEMLAGQAPF-EGEDEDELFQSIMEHNVAY----PKSMSKEAVAIC 572 Y ++VD W+ GV+L+ L+G PF E + L I + +S++A+ + Sbjct: 321 YNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLV 380 Query: 573 KGLMTKHPGKRLGCGPEGERDIKEHAFFRYID 604 K L+ P R + H + + D Sbjct: 381 KKLLVVDPKARFTT-----EEALRHPWLQDED 407 >3UDB-A nrPDB Length = 317 Score = 268 bits (686), Expect = 4e-72, Method: Composition-based stats. Identities = 80/270 (29%), Positives = 128/270 (47%), Gaps = 20/270 (7%) Query: 340 TDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK 399 + + +G G+FG L K +EL AVK +++ + ++ + + + + Sbjct: 19 DRYELVKDIGAGNFGVARLMRDKQANELVAVKYIERG-----EKIDENVKREIINHRSLR 73 Query: 400 PPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQS 459 P + + T L VMEY +GG+L I GRF E A F+ ++ G+ + + Sbjct: 74 HPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYAHA 133 Query: 460 KGIIYRDLKLDNVMLDSE--GHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQP 517 + +RDLKL+N +LD +KIADFG K ++ K+ GTP YIAPE++ + Sbjct: 134 MQVAHRDLKLENTLLDGSPAPRLKIADFGYSKASVLHS-QPKSAVGTPAYIAPEVLLKKE 192 Query: 518 YGKSV-DWWAFGVLLYEMLAGQAPFEGEDEDELFQS----IMEHNVAYPK--SMSKEAVA 570 Y V D W+ GV LY ML G PFE +E + F+ I+ A P +S E Sbjct: 193 YDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRH 252 Query: 571 ICKGLMTKHPGKRLGCGPEGERDIKEHAFF 600 + + P KR+ +I+ H +F Sbjct: 253 LISRIFVADPAKRISI-----PEIRNHEWF 277 >3ZUT-A nrPDB Length = 362 Score = 268 bits (685), Expect = 5e-72, Method: Composition-based stats. Identities = 78/270 (28%), Positives = 127/270 (47%), Gaps = 20/270 (7%) Query: 340 TDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK 399 + + +G G+FG L K ++EL AVK +++ + ++ + + + + Sbjct: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERG-----EKIDENVKREIINHRSLR 73 Query: 400 PPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQS 459 P + + T L VMEY +GG+L I GRF E A F+ ++ G+ + + Sbjct: 74 HPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHA 133 Query: 460 KGIIYRDLKLDNVMLDSE--GHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQP 517 + +RDLKL+N +LD +KI FG K ++ K+ GTP YIAPE++ + Sbjct: 134 MQVCHRDLKLENTLLDGSPAPRLKICAFGYSKSSVLHS-QPKSTVGTPAYIAPEVLLKKE 192 Query: 518 YGKSV-DWWAFGVLLYEMLAGQAPFEGEDEDELFQS----IMEHNVAYPK--SMSKEAVA 570 Y V D W+ GV LY ML G PFE +E + F+ I+ A P +S E Sbjct: 193 YDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRH 252 Query: 571 ICKGLMTKHPGKRLGCGPEGERDIKEHAFF 600 + + P KR+ +I+ H +F Sbjct: 253 LISRIFVADPAKRISI-----PEIRNHEWF 277 >3F3Z-A nrPDB Length = 277 Score = 267 bits (684), Expect = 8e-72, Method: Composition-based stats. Identities = 69/268 (25%), Positives = 126/268 (47%), Gaps = 18/268 (6%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 + +G+GS+G+V ++ +KGT A K + K V +DV+ E ++ P Sbjct: 11 YTLENTIGRGSWGEVKIAVQKGTRIRRAAKKIPKYFV---EDVDRFKQEIEIMKSLD-HP 66 Query: 402 FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKG 461 + +L+ F+ +Y VME GG+L + F+E A ++ + + Sbjct: 67 NIIRLYETFEDNTDIYLVMELCTGGELFERVVHKRVFRESDAARIMKDVLSAVAYCHKLN 126 Query: 462 IIYRDLKLDNVML---DSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY 518 + +RDLK +N + + +K+ DFG+ G +T GTP Y++P+++ Y Sbjct: 127 VAHRDLKPENFLFLTDSPDSPLKLIDFGLAARF-KPGKMMRTKVGTPYYVSPQVLEG-LY 184 Query: 519 GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPK----SMSKEAVAICKG 574 G D W+ GV++Y +L G PF + E+ I E +P+ ++S +A ++ + Sbjct: 185 GPECDEWSAGVMMYVLLCGYPPFSAPTDSEVMLKIREGTFTFPEKDWLNVSPQAESLIRR 244 Query: 575 LMTKHPGKRLGCGPEGERDIKEHAFFRY 602 L+TK P +R+ EH +F Sbjct: 245 LLTKSPKQRITSL-----QALEHEWFEK 267 >1ZWS-A nrPDB Length = 288 Score = 267 bits (684), Expect = 9e-72, Method: Composition-based stats. Identities = 83/289 (28%), Positives = 134/289 (46%), Gaps = 19/289 (6%) Query: 336 RMKLTDF-NFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDD---VECTMVEK 391 + K+ DF + LG G F V K T YA K +KK E E Sbjct: 7 QQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREV 66 Query: 392 RVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIA 451 +L +T LH ++ + ++E V+GG+L + Q E A + +I Sbjct: 67 SILRQVLHHNVIT-LHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQIL 125 Query: 452 IGLFFLQSKGIIYRDLKLDNVMLDSEG----HIKIADFGMCKENIWDGVTTKTFCGTPDY 507 G+ +L +K I + DLK +N+ML + HIK+ DFG+ E I DGV K GTP++ Sbjct: 126 DGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHE-IEDGVEFKNIFGTPEF 184 Query: 508 IAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPK----S 563 +APEI+ Y+P G D W+ GV+ Y +L+G +PF G+ + E +I + + + Sbjct: 185 VAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITSVSYDFDEEFFSH 244 Query: 564 MSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKE 612 S+ A + L+ K KRL ++ H + +D ++ + Sbjct: 245 TSELAKDFIRKLLVKETRKRLTI-----QEALRHPWITPVDNQQAMVRR 288 >4AF3-A nrPDB Length = 292 Score = 267 bits (682), Expect = 1e-71, Method: Composition-based stats. Identities = 82/280 (29%), Positives = 138/280 (49%), Gaps = 14/280 (5%) Query: 337 MKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLAL 396 + DF LGKG FG V L+ K + + A+K+L K + + + VE + + + Sbjct: 20 FTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQI-EKEGVEHQLRREIEIQA 78 Query: 397 PGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFF 456 P + +L++ F R+Y ++EY G+L +Q+ F E E+A L + Sbjct: 79 HLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMY 138 Query: 457 LQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQ 516 K +I+RD+K +N++L +G +KIADFG + KT CGT DY+ PE+I + Sbjct: 139 CHGKKVIHRDIKPENLLLGLKGELKIADFGWSVH--APSLRRKTMCGTLDYLPPEMIEGR 196 Query: 517 PYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLM 576 + + VD W GVL YE+L G PFE +E ++ I++ ++ +P S+ A + L+ Sbjct: 197 MHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPTGAQDLISKLL 256 Query: 577 TKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPP 616 +P +RL + H + R + + PP Sbjct: 257 RHNPSERLPLA-----QVSAHPWVRA------NSRRVLPP 285 >3COM-A nrPDB Length = 314 Score = 267 bits (682), Expect = 2e-71, Method: Composition-based stats. Identities = 68/287 (23%), Positives = 117/287 (40%), Gaps = 16/287 (5%) Query: 320 KTANTISKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVI 379 + K D + + + F+ L LG+GS+G V + K T ++ A+K + Sbjct: 10 PPRRQLKKLDEDSLTKQPEEV-FDVLEKLGEGSYGSVYKAIHKETGQIVAIKQV-----P 63 Query: 380 QDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQ-QVGRF 438 + D++ + E ++ P + + + + L+ VMEY G + I+ + Sbjct: 64 VESDLQEIIKEISIMQQCD-SPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTL 122 Query: 439 KEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTT 498 E GL +L I+RD+K N++L++EGH K+ADFG+ + Sbjct: 123 TEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKR 182 Query: 499 KTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHN- 557 T GTP ++APE+I Y D W+ G+ EM G+ P+ I + Sbjct: 183 NTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPP 242 Query: 558 --VAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRY 602 P+ S K + K P +R + +H F R Sbjct: 243 PTFRKPELWSDNFTDFVKQCLVKSPEQRATAT-----QLLQHPFVRS 284 >2Y7J-A nrPDB Length = 365 Score = 266 bits (680), Expect = 2e-71, Method: Composition-based stats. Identities = 69/278 (24%), Positives = 118/278 (42%), Gaps = 21/278 (7%) Query: 340 TDFNFLMVLGKGSFGKVMLSERKGTDELYAVKIL-----KKDVVIQDDDVECTMVEKRVL 394 ++ V+G+G V + T +AVKI+ + ++ E T E +L Sbjct: 94 QKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHIL 153 Query: 395 ALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGL 454 P + L +++ ++ V + + G+L ++ + E + + Sbjct: 154 RQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLEAV 213 Query: 455 FFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA 514 FL + I++RDLK +N++LD I+++DFG ++ G + CGTP Y+APEI+ Sbjct: 214 SFLHANNIVHRDLKPENILLDDNMQIRLSDFGFS-CHLEPGEKLRELCGTPGYLAPEILK 272 Query: 515 YQ------PYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAY----PKSM 564 YGK VD WA GV+L+ +LAG PF + + + IME + Sbjct: 273 CSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFSSPEWDDR 332 Query: 565 SKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRY 602 S + L+ P RL +H FF Sbjct: 333 SSTVKDLISRLLQVDPEARLTA-----EQALQHPFFER 365 >5XZW-A nrPDB Length = 471 Score = 265 bits (678), Expect = 4e-71, Method: Composition-based stats. Identities = 86/314 (27%), Positives = 140/314 (44%), Gaps = 31/314 (9%) Query: 307 RAKIGQGTKAPEEKTANTISKFDNNGNRDRMKLTDFNFL-MVLGKGSFGKVMLSERKGTD 365 R+ + +K ++ + K DF+ + V+G+G+F V + + T Sbjct: 164 RSNLKNTSKIASPGLTSSTASSMVANKTGIFK--DFSIIDEVVGQGAFATVKKAIERTTG 221 Query: 366 ELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNG 425 + +AVKI+ K VI + D E VL P + +L ++ + Y VME+V+G Sbjct: 222 KTFAVKIISKRKVIGNMD--GVTRELEVLQKLN-HPRIVRLKGFYEDTESYYMVMEFVSG 278 Query: 426 GDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGH--IKIA 483 GDLM + G E + +I + ++ S GI +RDLK DN++++ + +KI Sbjct: 279 GDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSMGISHRDLKPDNILIEQDDPVLVKIT 338 Query: 484 DFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQP-------------YGKSVDWWAFGVL 530 DFG+ K +G KTFCGT Y+APE+I + Y VD W+ G L Sbjct: 339 DFGLAK-VQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSPDEYEERNEYSSLVDMWSMGCL 397 Query: 531 LYEMLAGQAPFEGEDEDELFQSIMEHNVA----YPKSMSKEAVAICKGLMTKHPGKRLGC 586 +Y +L G PF G +D+L++ I + +S+EA L+ P R Sbjct: 398 VYVILTGHLPFSGSTQDQLYKQIGRGSYHEGPLKDFRISEEARDFIDSLLQVDPNNRSTA 457 Query: 587 GPEGERDIKEHAFF 600 H + Sbjct: 458 AK-----ALNHPWI 466 >3TAC-A nrPDB Length = 361 Score = 265 bits (678), Expect = 4e-71, Method: Composition-based stats. Identities = 72/276 (26%), Positives = 125/276 (45%), Gaps = 20/276 (7%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDV--ECTMVEKRVLALPGK 399 + V+GKG F V + T + +AVKI+ + E E + K Sbjct: 28 YELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASI-CHMLK 86 Query: 400 PPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR----FKEPHAVFYAAEIAIGLF 455 P + +L + + LY V E+++G DL + I + + E A Y +I L Sbjct: 87 HPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALR 146 Query: 456 FLQSKGIIYRDLKLDNVMLDSEGH---IKIADFGMCKENIWDGVTTKTFCGTPDYIAPEI 512 + II+RD+K V+L S+ + +K+ FG+ + G+ GTP ++APE+ Sbjct: 147 YCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFMAPEV 206 Query: 513 IAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAY----PKSMSKEA 568 + +PYGK VD W GV+L+ +L+G PF G E LF+ I++ +S+ A Sbjct: 207 VKREPYGKPVDVWGCGVILFILLSGCLPFYGTKER-LFEGIIKGKYKMNPRQWSHISESA 265 Query: 569 VAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYID 604 + + ++ P +R+ + H + + D Sbjct: 266 KDLVRRMLMLDPAERITVY-----EALNHPWLKERD 296 >3Q5I-A nrPDB Length = 504 Score = 265 bits (677), Expect = 5e-71, Method: Composition-based stats. Identities = 69/279 (24%), Positives = 129/279 (46%), Gaps = 23/279 (8%) Query: 340 TDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQ----DDDVECTMVEKRV-- 393 + + LG G++G+V+L + K A+K++KK + DD+ + + Sbjct: 36 ESYFKVRKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYSDDNKNIEKFHEEIYN 95 Query: 394 ---LALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEI 450 L P + +L F+ Y V E+ GG+L I +F E A +I Sbjct: 96 EISLLKSLDHPNIIKLFDVFEDKKYFYLVTEFYEGGELFEQIINRHKFDECDAANIMKQI 155 Query: 451 AIGLFFLQSKGIIYRDLKLDNVMLDSEG---HIKIADFGMCKENIWDGVTTKTFCGTPDY 507 G+ +L I++RD+K +N++L+++ +IKI DFG+ D + GT Y Sbjct: 156 LSGICYLHKHNIVHRDIKPENILLENKNSLLNIKIVDFGLSSFFSKD-YKLRDRLGTAYY 214 Query: 508 IAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAY----PKS 563 IAPE++ + Y + D W+ GV++Y +L G PF G+++ ++ + + + + K+ Sbjct: 215 IAPEVLK-KKYNEKCDVWSCGVIMYILLCGYPPFGGQNDQDIIKKVEKGKYYFDFNDWKN 273 Query: 564 MSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRY 602 +S EA + K ++T KR + + + Sbjct: 274 ISDEAKELIKLMLTYDYNKRCTA-----EEALNSRWIKK 307 >1PHK-A nrPDB Length = 298 Score = 264 bits (676), Expect = 7e-71, Method: Composition-based stats. Identities = 73/287 (25%), Positives = 119/287 (41%), Gaps = 22/287 (7%) Query: 340 TDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKK------DVVIQDDDVECTMVEKRV 393 ++ +LG+G V K T + YAVKI+ + E T+ E + Sbjct: 17 ENYEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQELREATLKEVDI 76 Query: 394 LALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIG 453 L P + QL ++T + V + + G+L ++ + E + Sbjct: 77 LRKVSGHPNIIQLKDTYETNTFFFLVFDLMKKGELFDYLTEKVTLSEKETRKIMRALLEV 136 Query: 454 LFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEII 513 + L I++RDLK +N++LD + +IK+ DFG + G + CGTP Y+APEII Sbjct: 137 ICALHKLNIVHRDLKPENILLDDDMNIKLTDFGFSCQL-DPGEKLREVCGTPSYLAPEII 195 Query: 514 AYQ------PYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAY----PKS 563 YGK VD W+ GV++Y +LAG PF + + + IM N + Sbjct: 196 ECSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFGSPEWDD 255 Query: 564 MSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLER 610 S + + P KR + H FF+ E++ Sbjct: 256 YSDTVKDLVSRFLVVQPQKRYTA-----EEALAHPFFQQYVVEEVRH 297 >3KN6-A nrPDB Length = 325 Score = 263 bits (672), Expect = 2e-70, Method: Composition-based stats. Identities = 80/253 (31%), Positives = 125/253 (49%), Gaps = 20/253 (7%) Query: 346 MVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQ 405 LG+GSF K +++ +AVKI+ K + T E L L P + + Sbjct: 17 KPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEA------NTQKEITALKLCEGHPNIVK 70 Query: 406 LHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYR 465 LH F + VME +NGG+L I++ F E A + ++ + + G+++R Sbjct: 71 LHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHR 130 Query: 466 DLKLDNVMLDSEG---HIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSV 522 DLK +N++ E IKI DFG + D KT C T Y APE++ Y +S Sbjct: 131 DLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYDESC 190 Query: 523 DWWAFGVLLYEMLAGQAPFEGEDED-------ELFQSIMEHNVAY----PKSMSKEAVAI 571 D W+ GV+LY ML+GQ PF+ D E+ + I + + ++ K++S+EA + Sbjct: 191 DLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDL 250 Query: 572 CKGLMTKHPGKRL 584 +GL+T P KRL Sbjct: 251 IQGLLTVDPNKRL 263 >4XEY-B nrPDB Length = 408 Score = 262 bits (671), Expect = 3e-70, Method: Composition-based stats. Identities = 71/275 (25%), Positives = 127/275 (46%), Gaps = 11/275 (4%) Query: 317 PEEKTAN-TISKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKK 375 P K T+ N ++ M+ TD LG G +G+V K AVK LK+ Sbjct: 101 PAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKE 160 Query: 376 DVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQV 435 D + +VE + E V+ K P L QL Y + E++ G+L+ ++++ Sbjct: 161 DTM----EVEEFLKEAAVMKEI-KHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLREC 215 Query: 436 GRFKEP--HAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIW 493 R + ++ A +I+ + +L+ K I+RDL N ++ +K+ADFG+ + Sbjct: 216 NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTG 275 Query: 494 DGVTTKTFCGTP-DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQ 551 D T P + APE +AY + D WAFGVLL+E+ G +P+ G D ++++ Sbjct: 276 DTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYE 335 Query: 552 SI-MEHNVAYPKSMSKEAVAICKGLMTKHPGKRLG 585 + ++ + P+ ++ + + +P R Sbjct: 336 LLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPS 370 >4LG4-A nrPDB Length = 299 Score = 262 bits (669), Expect = 4e-70, Method: Composition-based stats. Identities = 63/265 (23%), Positives = 114/265 (43%), Gaps = 15/265 (5%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 F+ L LG+GS+G V + K + ++ A+K + + D++ + E ++ P Sbjct: 13 FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQV-----PVESDLQEIIKEISIMQQCD-SP 66 Query: 402 FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQ-QVGRFKEPHAVFYAAEIAIGLFFLQSK 460 ++ + + + L+ VMEY G + I+ + E GL +L Sbjct: 67 YVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFM 126 Query: 461 GIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGK 520 I+R++K N++L++EGH K+ADFG+ + T GTP ++APE+I Y Sbjct: 127 RKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNC 186 Query: 521 SVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHN---VAYPKSMSKEAVAICKGLMT 577 D W+ G+ EM G+ P+ I + P+ S + K + Sbjct: 187 VADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLV 246 Query: 578 KHPGKRLGCGPEGERDIKEHAFFRY 602 K+P +R + +H F + Sbjct: 247 KNPEQRATAT-----QLLQHPFIKN 266 >2BPM-A nrPDB Length = 309 Score = 261 bits (667), Expect = 7e-70, Method: Composition-based stats. Identities = 69/299 (23%), Positives = 129/299 (43%), Gaps = 40/299 (13%) Query: 337 MKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLAL 396 + + +F + +G+G++G V + K T E+ A+K ++ D + + V T + + L Sbjct: 4 VDMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDT--ETEGVPSTAIREISLLK 61 Query: 397 PGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQV--GRFKEPHAVFYAAEIAIGL 454 P + +L T ++LY V E++ DL + P Y ++ GL Sbjct: 62 ELNHPNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGL 120 Query: 455 FFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA 514 F S +++RDLK N+++++EG IK+ADFG+ + T T Y APEI+ Sbjct: 121 AFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILL 180 Query: 515 YQP-YGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIM------------------E 555 Y +VD W+ G + EM+ +A F G+ E + I + Sbjct: 181 GCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPD 240 Query: 556 HNVAYPKS-----------MSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYI 603 + ++PK + ++ ++ ++ P KR+ + H FF+ + Sbjct: 241 YKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISA-----KAALAHPFFQDV 294 >2FO0-A nrPDB Length = 495 Score = 261 bits (667), Expect = 8e-70, Method: Composition-based stats. Identities = 70/275 (25%), Positives = 126/275 (45%), Gaps = 11/275 (4%) Query: 317 PEEKTAN-TISKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKK 375 P K T+ N ++ M+ TD LG G +G+V K AVK LK+ Sbjct: 193 PAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKE 252 Query: 376 DVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQV 435 D + +VE + E V+ K P L QL Y + E++ G+L+ ++++ Sbjct: 253 DTM----EVEEFLKEAAVMKEI-KHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLREC 307 Query: 436 GR--FKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIW 493 R ++ A +I+ + +L+ K I+R+L N ++ +K+ADFG+ + Sbjct: 308 NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRNLAARNCLVGENHLVKVADFGLSRLMTG 367 Query: 494 DGVTTKTFCGTP-DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQ 551 D T P + APE +AY + D WAFGVLL+E+ G +P+ G D ++++ Sbjct: 368 DTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYE 427 Query: 552 SI-MEHNVAYPKSMSKEAVAICKGLMTKHPGKRLG 585 + ++ + P+ ++ + + +P R Sbjct: 428 LLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPS 462 >2F57-A nrPDB Length = 317 Score = 261 bits (666), Expect = 8e-70, Method: Composition-based stats. Identities = 67/258 (25%), Positives = 124/258 (48%), Gaps = 13/258 (5%) Query: 347 VLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQL 406 +G+GS G V ++ K T + AVK + ++ + + V+ + + Sbjct: 52 KIGEGSTGIVCIATEKHTGKQVAVKKMD----LRKQQRRELLFNEVVIMRDYHHDNVVDM 107 Query: 407 HSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRD 466 +S + D L+ VME++ GG L I R E + L +L ++G+I+RD Sbjct: 108 YSSYLVGDELWVVMEFLEGGALTD-IVTHTRMNEEQIATVCLSVLRALSYLHNQGVIHRD 166 Query: 467 LKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWA 526 +K D+++L S+G IK++DFG C + + K+ GTP ++APE+I+ PYG VD W+ Sbjct: 167 IKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWS 226 Query: 527 FGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKS---MSKEAVAICKGLMTKHPGKR 583 G+++ EM+ G+ P+ E + + I + K +S ++ + P +R Sbjct: 227 LGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVSSVLRGFLDLMLVREPSQR 286 Query: 584 LGCGPEGERDIKEHAFFR 601 +++ H F + Sbjct: 287 ATA-----QELLGHPFLK 299 >3GUB-A nrPDB Length = 295 Score = 261 bits (666), Expect = 9e-70, Method: Composition-based stats. Identities = 76/271 (28%), Positives = 121/271 (44%), Gaps = 18/271 (6%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDD---VECTMVEKRVLALPG 398 ++ LG G F V K T YA K +KK E E +L Sbjct: 13 YDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEI- 71 Query: 399 KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQ 458 + P + LH ++ + + E V GG+L + + E A + +I G+++L Sbjct: 72 QHPNVITLHEVYENKTDVILIGELVAGGELFDFLAEKESLTEEEATEFLKQILNGVYYLH 131 Query: 459 SKGIIYRDLKLDNVMLDSEG----HIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA 514 S I + DLK +N+ML IKI DFG+ I G K GTP+++APEI+ Sbjct: 132 SLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLA-HKIDFGNEFKNIFGTPEFVAPEIVN 190 Query: 515 YQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPK----SMSKEAVA 570 Y+P G D W+ GV+ Y +L+G +PF G+ + E ++ N + + S A Sbjct: 191 YEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFSNTSALAKD 250 Query: 571 ICKGLMTKHPGKRLGCGPEGERDIKEHAFFR 601 + L+ K P KR+ +D +H + + Sbjct: 251 FIRRLLVKDPKKRMTI-----QDSLQHPWIK 276 >6FDY-U nrPDB Length = 276 Score = 260 bits (665), Expect = 1e-69, Method: Composition-based stats. Identities = 75/268 (27%), Positives = 125/268 (46%), Gaps = 14/268 (5%) Query: 338 KLTDFNFLMVLGKGSFGKVMLSE-RKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLAL 396 +L F LG G++ V + +K T E+ A+K + K + VE + E +L Sbjct: 9 RLDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKS-LNKASVENLLTEIEILKG 67 Query: 397 PGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFF 456 + P + QL D +Y +ME+ GGDL I E A + ++A L F Sbjct: 68 I-RHPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQF 126 Query: 457 LQSKGIIYRDLKLDNVMLD--SEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA 514 L + I + DLK N++L + H+K+ADFG +++ G+P Y+APE++ Sbjct: 127 LHERNISHLDLKPQNILLSSLEKPHLKLADFGFA-QHMSPWDEKHVLRGSPLYMAPEMVC 185 Query: 515 YQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEH---NVAYPKSMSKEAVAI 571 + Y VD W+ GV+LYE L GQ PF EL + I + + +S++ + Sbjct: 186 QRQYDARVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRPLLSRDCRDL 245 Query: 572 CKGLMTKHPGKRLGCGPEGERDIKEHAF 599 + L+ + P +R+ +D H + Sbjct: 246 LQRLLERDPSRRIS-----FQDFFAHPW 268 >6AO5-A nrPDB Length = 362 Score = 260 bits (664), Expect = 2e-69, Method: Composition-based stats. Identities = 63/265 (23%), Positives = 114/265 (43%), Gaps = 15/265 (5%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 F+ L LG+GS+G V + K + ++ A+K + + D++ + E ++ P Sbjct: 12 FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQV-----PVESDLQEIIKEISIMQQCD-SP 65 Query: 402 FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQ-QVGRFKEPHAVFYAAEIAIGLFFLQSK 460 ++ + + + L+ VMEY G + I+ + E GL +L Sbjct: 66 YVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFM 125 Query: 461 GIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGK 520 I+R++K N++L++EGH K+ADFG+ + T GTP ++APE+I Y Sbjct: 126 RKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNC 185 Query: 521 SVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHN---VAYPKSMSKEAVAICKGLMT 577 D W+ G+ EM G+ P+ I + P+ S + K + Sbjct: 186 VADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLV 245 Query: 578 KHPGKRLGCGPEGERDIKEHAFFRY 602 K+P +R + +H F + Sbjct: 246 KNPEQRATAT-----QLLQHPFIKN 265 >5JZN-A nrPDB Length = 280 Score = 259 bits (662), Expect = 3e-69, Method: Composition-based stats. Identities = 81/284 (28%), Positives = 125/284 (44%), Gaps = 22/284 (7%) Query: 327 KFDNNGNRDRMKLTD-FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVE 385 + G + +T+ + +G G+F V + T YA+KI+KK + + Sbjct: 5 EVSEEGFQIPATITERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHM- 63 Query: 386 CTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVF 445 E +L K P + L LY VME V GGDL I ++ E A Sbjct: 64 -IQNEVSILRRV-KHPNIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASG 121 Query: 446 YAAEIAIGLFFLQSKGIIYRDLKLDNVML----DSEGHIKIADFGMCKENIWDGVTTKTF 501 +A + +L S I++RD+K +N+++ D +K+ DFG+ T Sbjct: 122 MLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGP---LYTV 178 Query: 502 CGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDE--LFQSIMEHNVA 559 CGTP Y+APEIIA YG VD WA GV+ Y +L G PF G +D+ LF I+ V Sbjct: 179 CGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVD 238 Query: 560 YP----KSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAF 599 +P ++S A + ++ +R + EH + Sbjct: 239 FPSPYWDNVSDSAKELITMMLLVDVDQRFSAV-----QVLEHPW 277 >2YCR-A nrPDB Length = 323 Score = 259 bits (661), Expect = 4e-69, Method: Composition-based stats. Identities = 82/313 (26%), Positives = 139/313 (44%), Gaps = 28/313 (8%) Query: 336 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVE-----CTMVE 390 + ++ LG G+ G+V L+ + T + A+KI+ K E E Sbjct: 6 KALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETE 65 Query: 391 KRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEI 450 +L P + ++ + F D Y V+E + GG+L + R KE Y ++ Sbjct: 66 IEILKKLN-HPCIIKIKNFFDAEDY-YIVLELMEGGELFDKVVGNKRLKEATCKLYFYQM 123 Query: 451 AIGLFFLQSKGIIYRDLKLDNVMLD---SEGHIKIADFGMCKENIWDGVTTKTFCGTPDY 507 + + +L GII+RDLK +NV+L + IKI DFG K + + +T CGTP Y Sbjct: 124 LLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSK-ILGETSLMRTLCGTPTY 182 Query: 508 IAPEII---AYQPYGKSVDWWAFGVLLYEMLAGQAPF-EGEDEDELFQSIMEHNVAY--- 560 +APE++ Y ++VD W+ GV+L+ L+G PF E + L I + Sbjct: 183 LAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPE 242 Query: 561 -PKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYID----WEKLERKEIQP 615 +S++A+ + K L+ P R + H + + D ++ L +E + Sbjct: 243 VWAEVSEKALDLVKKLLVVDPKARFTT-----EEALRHPWLQDEDMKRKFQDLLSEENES 297 Query: 616 PYKPKARDKRDTS 628 KP+ + TS Sbjct: 298 TAKPQVLAQPSTS 310 >2XYN-A nrPDB Length = 292 Score = 257 bits (657), Expect = 9e-69, Method: Composition-based stats. Identities = 69/260 (26%), Positives = 119/260 (45%), Gaps = 10/260 (3%) Query: 331 NGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVE 390 + ++ M+ TD LG G +G+V + K AVK LK+D + +VE + E Sbjct: 23 SMDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTM----EVEEFLKE 78 Query: 391 KRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR--FKEPHAVFYAA 448 V+ K P L QL Y V EY+ G+L+ ++++ R ++ A Sbjct: 79 AAVMKEI-KHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMAT 137 Query: 449 EIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTP-DY 507 +I+ + +L+ K I+RDL N ++ +K+ADFG+ + D T P + Sbjct: 138 QISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKW 197 Query: 508 IAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIMEH-NVAYPKSMS 565 APE +AY + D WAFGVLL+E+ G +P+ G D +++ + + + P+ Sbjct: 198 TAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCP 257 Query: 566 KEAVAICKGLMTKHPGKRLG 585 + + + P R Sbjct: 258 PKVYELMRACWKWSPADRPS 277 >6NPU-A nrPDB Length = 298 Score = 257 bits (657), Expect = 1e-68, Method: Composition-based stats. Identities = 68/262 (25%), Positives = 123/262 (46%), Gaps = 10/262 (3%) Query: 329 DNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTM 388 N ++ M+ TD LG G +G+V K AVK LK+D + +VE + Sbjct: 15 SPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTM----EVEEFL 70 Query: 389 VEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEP--HAVFY 446 E V+ K P L QL Y + E++ G+L+ ++++ R + ++ Sbjct: 71 KEAAVMKEI-KHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYM 129 Query: 447 AAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTP- 505 A +I+ + +L+ K I+RDL N ++ +K+ADFG+ + D T P Sbjct: 130 ATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPI 189 Query: 506 DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSI-MEHNVAYPKS 563 + APE +AY + D WAFGVLL+E+ G +P+ G D ++++ + ++ + P+ Sbjct: 190 KWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEG 249 Query: 564 MSKEAVAICKGLMTKHPGKRLG 585 ++ + + +P R Sbjct: 250 CPEKVYELMRACWQWNPSDRPS 271 >6FD3-A nrPDB Length = 300 Score = 256 bits (655), Expect = 2e-68, Method: Composition-based stats. Identities = 61/264 (23%), Positives = 115/264 (43%), Gaps = 13/264 (4%) Query: 341 DFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKP 400 + +G+G+ G V + T + A+K + + + ++ + ++ K Sbjct: 23 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKE----LIINEILVMRENKN 78 Query: 401 PFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSK 460 P + + D L+ VMEY+ GG L + + E E L FL S Sbjct: 79 PNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETC-MDEGQIAAVCRECLQALDFLHSN 137 Query: 461 GIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGK 520 +I+RD+K DN++L +G +K+ DFG C + + T GTP ++APE++ + YG Sbjct: 138 QVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGP 197 Query: 521 SVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEH---NVAYPKSMSKEAVAICKGLMT 577 VD W+ G++ EM+ G+ P+ E+ I + + P+ +S + Sbjct: 198 KVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLE 257 Query: 578 KHPGKRLGCGPEGERDIKEHAFFR 601 +R +++ +H F + Sbjct: 258 MDVDRR-----GSAKELLQHPFLK 276 >4PDS-A nrPDB Length = 347 Score = 256 bits (653), Expect = 3e-68, Method: Composition-based stats. Identities = 81/283 (28%), Positives = 131/283 (46%), Gaps = 29/283 (10%) Query: 339 LTDFNFL-MVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALP 397 DF+ + V+G+G+F V + + T + ++VKI+ K VI + D E VL Sbjct: 29 FKDFSIIDEVVGQGAFATVKKAIERTTGKTFSVKIISKRKVIGNMD--GVTRELEVLQKL 86 Query: 398 GKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFL 457 P + +L ++ + Y VME+V+GGDLM + G E + +I + ++ Sbjct: 87 N-HPRIVRLKGFYEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYI 145 Query: 458 QSKGIIYRDLKLDNVMLDSEGH--IKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAY 515 S GI +RDLK DN++++ + +KI FG+ K +G KTFCGT Y+APE+I Sbjct: 146 HSMGISHRDLKPDNILIEQDDPVLVKITAFGLAK-VQGNGSFMKTFCGTLAYVAPEVIRG 204 Query: 516 QP-------------YGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVA--- 559 + Y VD W+ G L+Y +L G PF G +D+L++ I + Sbjct: 205 KDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRGSYHEGP 264 Query: 560 -YPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFR 601 +S+EA L+ P R H + + Sbjct: 265 LKDFRISEEARDFIDSLLQVDPNNRSTAAK-----ALNHPWIK 302 >6CMJ-A nrPDB Length = 321 Score = 256 bits (653), Expect = 3e-68, Method: Composition-based stats. Identities = 81/288 (28%), Positives = 133/288 (46%), Gaps = 22/288 (7%) Query: 327 KFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDD--- 383 G +D ++L + +GKGS+G V L+ + + YA+K+L K +I+ Sbjct: 21 HVSITGMQDCVQLDQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGGCI 80 Query: 384 -----VECTMVEKRVLALPGKPPFLTQLHSCFQT--MDRLYFVMEYVNGGDLMYHIQQVG 436 +E E +L P + +L D LY V E VN G +M + + Sbjct: 81 QPRGPIEQVYQEIAILKKLD-HPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTLK 138 Query: 437 RFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGV 496 E A FY ++ G+ +L + II+RD+K N+++ +GHIKIADFG+ E Sbjct: 139 PLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDA 198 Query: 497 TTKTFCGTPDYIAPEIIAYQP---YGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSI 553 GTP ++APE ++ GK++D WA GV LY + GQ PF E L I Sbjct: 199 LLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKI 258 Query: 554 MEHNVAYPK--SMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAF 599 + +P ++++ + ++ K+P R+ +IK H + Sbjct: 259 KSQALEFPDQPDIAEDLKDLITRMLDKNPESRI-----VVPEIKLHPW 301 >4FIE-A nrPDB Length = 423 Score = 255 bits (651), Expect = 5e-68, Method: Composition-based stats. Identities = 72/316 (22%), Positives = 143/316 (45%), Gaps = 17/316 (5%) Query: 289 PVPPEGSEGNEELRQKFERAKIGQG-TKAPEEKTANTISKFDNNGNRDRMKLTDFNFLMV 347 P PP + + +K + Q + + + + R L +F Sbjct: 102 PPPPARARQENGMPEKPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFI---K 158 Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 407 +G+GS G V ++ + + +L AVK + ++ + + V+ + + +++ Sbjct: 159 IGEGSTGIVCIATVRSSGKLVAVKKMD----LRKQQRRELLFNEVVIMRDYQHENVVEMY 214 Query: 408 SCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDL 467 + + D L+ VME++ GG L I R E + L L ++G+I+RD+ Sbjct: 215 NSYLVGDELWVVMEFLEGGALTD-IVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDI 273 Query: 468 KLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAF 527 K D+++L +G +K++DFG C + + K+ GTP ++APE+I+ PYG VD W+ Sbjct: 274 KSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSL 333 Query: 528 GVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKS---MSKEAVAICKGLMTKHPGKRL 584 G+++ EM+ G+ P+ E + + I ++ K+ +S L+ + P +R Sbjct: 334 GIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRA 393 Query: 585 GCGPEGERDIKEHAFF 600 ++ +H F Sbjct: 394 TAA-----ELLKHPFL 404 >3LM0-A nrPDB Length = 327 Score = 255 bits (651), Expect = 6e-68, Method: Composition-based stats. Identities = 92/307 (29%), Positives = 143/307 (46%), Gaps = 21/307 (6%) Query: 338 KLTDFNFL--MVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 395 +F L LG+G F V K T + YA K LKK QD E + E VL Sbjct: 25 NFNNFYILTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAE-ILHEIAVLE 83 Query: 396 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHI--QQVGRFKEPHAVFYAAEIAIG 453 L P + LH ++ + ++EY GG++ + E + +I G Sbjct: 84 LAKSCPRVINLHEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEG 143 Query: 454 LFFLQSKGIIYRDLKLDNVMLDS---EGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAP 510 +++L I++ DLK N++L S G IKI DFGM ++ I + GTP+Y+AP Sbjct: 144 VYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRK-IGHACELREIMGTPEYLAP 202 Query: 511 EIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPK----SMSK 566 EI+ Y P + D W G++ Y +L +PF GED E + +I + NV Y + S+S+ Sbjct: 203 EILNYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFSSVSQ 262 Query: 567 EAVAICKGLMTKHPGKRLGCGPEGERDI-KEHAFFRYIDWEKLERKEIQPPYKPKARDKR 625 A + L+ K+P KR +I H++ + D+E L E + + +D Sbjct: 263 LATDFIQSLLVKNPEKRPTA------EICLSHSWLQQWDFENLFHPE-ETSSSSQTQDHS 315 Query: 626 DTSNFDK 632 S+ DK Sbjct: 316 VRSSEDK 322 >4QMW-A nrPDB Length = 310 Score = 254 bits (650), Expect = 7e-68, Method: Composition-based stats. Identities = 75/293 (25%), Positives = 132/293 (45%), Gaps = 14/293 (4%) Query: 309 KIGQGTKAPEEKTANTISKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELY 368 +G A + + + + + F L +GKGSFG+V T ++ Sbjct: 2 PLGSEFMAHSPVQSGLPGMQNLKADPEEL----FTKLEKIGKGSFGEVFKGIDNRTQKVV 57 Query: 369 AVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDL 428 A+KI+ D+ +D++E E VL+ P++T+ + + +L+ +MEY+ GG Sbjct: 58 AIKII--DLEEAEDEIEDIQQEITVLSQCD-SPYVTKYYGSYLKDTKLWIIMEYLGGGSA 114 Query: 429 MYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMC 488 + + + G E EI GL +L S+ I+RD+K NV+L G +K+ADFG+ Sbjct: 115 LDLL-EPGPLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVA 173 Query: 489 KENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDE 548 + + TF GTP ++APE+I Y D W+ G+ E+ G+ P + Sbjct: 174 GQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSELHPMK 233 Query: 549 LFQSIMEHN-VAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFF 600 + I ++N + SK + + K P R +++ +H F Sbjct: 234 VLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTA-----KELLKHKFI 281 >2Q0N-A nrPDB Length = 301 Score = 254 bits (649), Expect = 9e-68, Method: Composition-based stats. Identities = 64/257 (24%), Positives = 126/257 (49%), Gaps = 13/257 (5%) Query: 347 VLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQL 406 +G+GS G V ++ + + +L AVK + ++ + + V+ + + ++ Sbjct: 36 KIGEGSTGIVCIATVRSSGKLVAVKKMD----LRKQQRRELLFNEVVIMRDYQHENVVEM 91 Query: 407 HSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRD 466 ++ + D L+ VME++ GG L I R E + L L ++G+I+RD Sbjct: 92 YNSYLVGDELWVVMEFLEGGALTD-IVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRD 150 Query: 467 LKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWA 526 +K D+++L +G +K++DFG C + + K+ GTP ++APE+I+ PYG VD W+ Sbjct: 151 IKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWS 210 Query: 527 FGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKS---MSKEAVAICKGLMTKHPGKR 583 G+++ EM+ G+ P+ E + + I ++ K+ +S L+ + P +R Sbjct: 211 LGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQR 270 Query: 584 LGCGPEGERDIKEHAFF 600 ++ +H F Sbjct: 271 ATAA-----ELLKHPFL 282 >4XBR-A nrPDB Length = 366 Score = 254 bits (649), Expect = 9e-68, Method: Composition-based stats. Identities = 71/316 (22%), Positives = 143/316 (45%), Gaps = 17/316 (5%) Query: 288 VPVPPEGSEGNEELRQKFERAKIGQGTKAPEEKTANTISKFDNNGNRDRMKLTDFNFLMV 347 + +P E R+ + + E+ + + G+ L +F Sbjct: 46 MELPEEFPAAPAVPGPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSY-LDNFI---K 101 Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 407 +G+GS G V ++ + + +L AVK + ++ + + V+ + + +++ Sbjct: 102 IGEGSTGIVCIATVRSSGKLVAVKKMD----LRKQQRRELLFNEVVIMRDYQHENVVEMY 157 Query: 408 SCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDL 467 + + D L+ VME++ GG L I R E + L L ++G+I+RD+ Sbjct: 158 NSYLVGDELWVVMEFLEGGALTD-IVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDI 216 Query: 468 KLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAF 527 K D+++L +G +K++DFG C + + K+ GTP ++APE+I+ PYG VD W+ Sbjct: 217 KSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSL 276 Query: 528 GVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKS---MSKEAVAICKGLMTKHPGKRL 584 G+++ EM+ G+ P+ E + + I ++ K+ +S L+ + P +R Sbjct: 277 GIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRA 336 Query: 585 GCGPEGERDIKEHAFF 600 ++ +H F Sbjct: 337 TAA-----ELLKHPFL 347 >4JDH-A nrPDB Length = 346 Score = 254 bits (648), Expect = 1e-67, Method: Composition-based stats. Identities = 64/257 (24%), Positives = 126/257 (49%), Gaps = 13/257 (5%) Query: 347 VLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQL 406 +G+GS G V ++ + + +L AVK + ++ + + V+ + + ++ Sbjct: 81 KIGEGSTGIVCIATVRSSGKLVAVKKMD----LRKQQRRELLFNEVVIMRDYQHENVVEM 136 Query: 407 HSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRD 466 ++ + D L+ VME++ GG L I R E + L L ++G+I+RD Sbjct: 137 YNSYLVGDELWVVMEFLEGGALTD-IVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRD 195 Query: 467 LKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWA 526 +K D+++L +G +K++DFG C + + K+ GTP ++APE+I+ PYG VD W+ Sbjct: 196 IKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWS 255 Query: 527 FGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKS---MSKEAVAICKGLMTKHPGKR 583 G+++ EM+ G+ P+ E + + I ++ K+ +S L+ + P +R Sbjct: 256 LGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQR 315 Query: 584 LGCGPEGERDIKEHAFF 600 ++ +H F Sbjct: 316 ATAA-----ELLKHPFL 327 >4KS7-A nrPDB Length = 292 Score = 254 bits (648), Expect = 1e-67, Method: Composition-based stats. Identities = 59/257 (22%), Positives = 124/257 (48%), Gaps = 13/257 (5%) Query: 347 VLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQL 406 +G+GS G V L+ K + AVK++ ++ + + V+ + + ++ Sbjct: 30 KIGEGSTGIVCLAREKHSGRQVAVKMMD----LRKQQRRELLFNEVVIMRDYQHFNVVEM 85 Query: 407 HSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRD 466 + + + L+ +ME++ GG L I R E + L +L ++G+I+RD Sbjct: 86 YKSYLVGEELWVLMEFLQGGALTD-IVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRD 144 Query: 467 LKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWA 526 +K D+++L +G +K++DFG C + D K+ GTP ++APE+I+ Y VD W+ Sbjct: 145 IKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWS 204 Query: 527 FGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKS---MSKEAVAICKGLMTKHPGKR 583 G+++ EM+ G+ P+ + + + + + K+ +S + ++ + P +R Sbjct: 205 LGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQER 264 Query: 584 LGCGPEGERDIKEHAFF 600 +++ +H F Sbjct: 265 ATA-----QELLDHPFL 276 >6GU6-A nrPDB Length = 302 Score = 253 bits (647), Expect = 1e-67, Method: Composition-based stats. Identities = 60/299 (20%), Positives = 123/299 (41%), Gaps = 41/299 (13%) Query: 339 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 398 + D+ + +G+G++G V K T ++ A+K ++ + +++ V T + + L Sbjct: 6 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLES--EEEGVPSTAIREISLLKEL 63 Query: 399 KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR---FKEPHAVFYAAEIAIGLF 455 + P + L RLY + E+++ DL ++ + Y +I G+ Sbjct: 64 RHPNIVSLQDVLMQDSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIV 122 Query: 456 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAY 515 F S+ +++RDLK N+++D +G IK+ADFG+ + T Y +PE++ Sbjct: 123 FCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLG 182 Query: 516 Q-PYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIM------------------EH 556 Y VD W+ G + E+ + F G+ E + I ++ Sbjct: 183 SARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDY 242 Query: 557 NVAYP-----------KSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYID 604 +P K++ + + + ++ P KR+ + H +F +D Sbjct: 243 KNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRIS-----GKMALNHPYFNDLD 296 >5A46-A nrPDB Length = 386 Score = 252 bits (645), Expect = 2e-67, Method: Composition-based stats. Identities = 86/339 (25%), Positives = 145/339 (42%), Gaps = 32/339 (9%) Query: 334 RDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDE-------LYAVKILKKDVVIQDDDVEC 386 R + LG+G FG+V+L+E G D+ AVK+LK D + D+ Sbjct: 34 RWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDAT--EKDLSD 91 Query: 387 TMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR--------- 437 + E ++ + GK + L LY ++EY + G+L ++Q Sbjct: 92 LISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNP 151 Query: 438 -------FKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKE 490 V A ++A G+ +L SK I+RDL NV++ + +KIADFG+ ++ Sbjct: 152 SHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARD 211 Query: 491 NIWDGVTTKTFCGTP--DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDED 547 KT G ++APE + + Y D W+FGVLL+E+ G +P+ G + Sbjct: 212 IHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVE 271 Query: 548 ELFQSIME-HNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWE 606 ELF+ + E H + P + + E + + P +R E + A ++ Sbjct: 272 ELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYL 331 Query: 607 KLERK--EIQPPYKPKARDKRDTSNFDKEFTRQPVELTP 643 L + P + P R +S D F+ +P+ P Sbjct: 332 DLSMPLDQYSPSF-PDTRSSTCSSGEDSVFSHEPLPEEP 369 >3TT0-A nrPDB Length = 382 Score = 251 bits (642), Expect = 7e-67, Method: Composition-based stats. Identities = 75/279 (26%), Positives = 126/279 (45%), Gaps = 29/279 (10%) Query: 334 RDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDE-------LYAVKILKKDVVIQDDDVEC 386 R + LG+G+FG+V+L+E G D+ AVK+LK D + D+ Sbjct: 63 RWELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDAT--EKDLSD 120 Query: 387 TMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR--------- 437 + E ++ + GK + L LY ++EY + G+L ++Q Sbjct: 121 LISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYSYNP 180 Query: 438 -------FKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKE 490 V A ++A G+ +L SK I+RDL NV++ + +KIADFG+ ++ Sbjct: 181 SHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARD 240 Query: 491 NIWDGVTTKTFCGTP--DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDED 547 KT G ++APE + + Y D W+FGVLL+E+ G +P+ G + Sbjct: 241 IHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVE 300 Query: 548 ELFQSIME-HNVAYPKSMSKEAVAICKGLMTKHPGKRLG 585 ELF+ + E H + P + + E + + P +R Sbjct: 301 ELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPT 339 >4AGU-A nrPDB Length = 311 Score = 251 bits (641), Expect = 8e-67, Method: Composition-based stats. Identities = 65/311 (20%), Positives = 118/311 (37%), Gaps = 42/311 (13%) Query: 339 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 398 + + + +G+GS+G V + T ++ A+K + + + E R+L Sbjct: 2 MEKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKF-LESEDDPVIKKIALREIRMLKQL- 59 Query: 399 KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQ 458 K P L L F+ RL+ V EY + L + E + + F Sbjct: 60 KHPNLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFCH 119 Query: 459 SKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQP- 517 I+RD+K +N+++ IK+ DFG + T Y +PE++ Sbjct: 120 KHNCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYDDEVATRWYRSPELLVGDTQ 179 Query: 518 YGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEH--------------------- 556 YG VD WA G + E+L+G + G+ + + I + Sbjct: 180 YGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFSGV 239 Query: 557 -----------NVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYI-D 604 + +P ++S A+ + KG + P +RL C + H +F I + Sbjct: 240 KIPDPEDMEPLELKFP-NISYPALGLLKGCLHMDPTERLTC-----EQLLHHPYFENIRE 293 Query: 605 WEKLERKEIQP 615 E L ++ +P Sbjct: 294 IEDLAKEHDKP 304 >3NIZ-A nrPDB Length = 311 Score = 250 bits (639), Expect = 1e-66, Method: Composition-based stats. Identities = 60/299 (20%), Positives = 120/299 (40%), Gaps = 43/299 (14%) Query: 339 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 398 + + L +G+G++G V ++ + A+K ++ D +D+ + T + + L Sbjct: 20 MEKYQKLEKVGEGTYGVVYKAKD-SQGRIVALKRIRLDA--EDEGIPSTAIREISLLKEL 76 Query: 399 KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR-FKEPHAVFYAAEIAIGLFFL 457 P + L + L V E++ DL + + ++ Y ++ G+ Sbjct: 77 HHPNIVSLIDVIHSERCLTLVFEFMEK-DLKKVLDENKTGLQDSQIKIYLYQLLRGVAHC 135 Query: 458 QSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAY-Q 516 I++RDLK N++++S+G +K+ADFG+ + + T Y AP+++ + Sbjct: 136 HQHRILHRDLKPQNLLINSDGALKLADFGLARAFGIPVRSYTHEVVTLWYRAPDVLMGSK 195 Query: 517 PYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSI---------------------ME 555 Y SVD W+ G + EM+ G+ F G +D+ I + Sbjct: 196 KYSTSVDIWSIGCIFAEMITGKPLFPGVTDDDQLPKIFSILGTPNPREWPQVQELPLWKQ 255 Query: 556 HNVA----------YPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYID 604 P +E + + ++ P KR+ RD H +F+ +D Sbjct: 256 RTFQVFEKKPWSSIIPGFC-QEGIDLLSNMLCFDPNKRISA-----RDAMNHPYFKDLD 308 >3Q53-A nrPDB Length = 306 Score = 250 bits (639), Expect = 1e-66, Method: Composition-based stats. Identities = 61/264 (23%), Positives = 115/264 (43%), Gaps = 13/264 (4%) Query: 341 DFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKP 400 + +G+G+ G V + T + A++ + + + ++ + ++ K Sbjct: 22 KYTRFEKIGQGASGTVYTAMDVATGQEVAIRQMNLQQQPKKE----LIINEILVMRENKN 77 Query: 401 PFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSK 460 P + + D L+ VMEY+ GG L + + E E L FL S Sbjct: 78 PNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETC-MDEGQIAAVCRECLQALEFLHSN 136 Query: 461 GIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGK 520 +I+RD+K DN++L +G +K+ DFG C + + T GTP ++APE++ + YG Sbjct: 137 QVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGP 196 Query: 521 SVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEH---NVAYPKSMSKEAVAICKGLMT 577 VD W+ G++ EM+ G+ P+ E+ I + + P+ +S + Sbjct: 197 KVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLE 256 Query: 578 KHPGKRLGCGPEGERDIKEHAFFR 601 KR +++ +H F + Sbjct: 257 MDVEKR-----GSAKELIQHQFLK 275 >3GQL-A nrPDB Length = 326 Score = 249 bits (637), Expect = 2e-66, Method: Composition-based stats. Identities = 75/279 (26%), Positives = 126/279 (45%), Gaps = 29/279 (10%) Query: 334 RDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDE-------LYAVKILKKDVVIQDDDVEC 386 R + LG+G+FG+V+L+E G D+ AVK+LK D + D+ Sbjct: 22 RWELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDAT--EKDLSD 79 Query: 387 TMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR--------- 437 + E ++ + GK + L LY ++EY + G+L ++Q Sbjct: 80 LISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNP 139 Query: 438 -------FKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKE 490 V A ++A G+ +L SK I+RDL NV++ + +KIADFG+ ++ Sbjct: 140 SHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARD 199 Query: 491 NIWDGVTTKTFCGTP--DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDED 547 KT G ++APE + + Y D W+FGVLL+E+ G +P+ G + Sbjct: 200 IHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVE 259 Query: 548 ELFQSIME-HNVAYPKSMSKEAVAICKGLMTKHPGKRLG 585 ELF+ + E H + P + + E + + P +R Sbjct: 260 ELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPT 298 >2XIK-A nrPDB Length = 294 Score = 249 bits (636), Expect = 3e-66, Method: Composition-based stats. Identities = 76/278 (27%), Positives = 128/278 (46%), Gaps = 10/278 (3%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 F L +GKGSFG+V T E+ A+KI+ D+ +D++E E VL+ P Sbjct: 21 FTKLDRIGKGSFGEVYKGIDNHTKEVVAIKII--DLEEAEDEIEDIQQEITVLSQCD-SP 77 Query: 402 FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKG 461 ++T+ + +L+ +MEY+ GG + + + G +E + EI GL +L S+ Sbjct: 78 YITRYFGSYLKSTKLWIIMEYLGGGSALDLL-KPGPLEETYIATILREILKGLDYLHSER 136 Query: 462 IIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKS 521 I+RD+K NV+L +G +K+ADFG+ + + TF GTP ++APE+I Y Sbjct: 137 KIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFK 196 Query: 522 VDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEH-NVAYPKSMSKEAVAICKGLMTKHP 580 D W+ G+ E+ G+ P + I ++ SK + + K P Sbjct: 197 ADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQHSKPFKEFVEACLNKDP 256 Query: 581 GKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYK 618 R +++ +H F + E+ YK Sbjct: 257 RFRPTA-----KELLKHKFITRYTKKTSFLTELIDRYK 289 >2UV2-A nrPDB Length = 325 Score = 249 bits (636), Expect = 3e-66, Method: Composition-based stats. Identities = 70/273 (25%), Positives = 118/273 (43%), Gaps = 19/273 (6%) Query: 337 MKLTDF-NFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 395 + DF + LG G+FGKV ++ K T L A K++ ++++E MVE +LA Sbjct: 33 LNPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTK---SEEELEDYMVEIDILA 89 Query: 396 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYH-IQQVGRFKEPHAVFYAAEIAIGL 454 P + +L F + L+ ++E+ GG + ++ E + L Sbjct: 90 -SCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDAL 148 Query: 455 FFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA 514 +L II+RDLK N++ +G IK+ADFG+ +N +F GTP ++APE++ Sbjct: 149 NYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVM 208 Query: 515 -----YQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHN---VAYPKSMSK 566 +PY D W+ G+ L EM + P + + I + +A P S Sbjct: 209 CETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSS 268 Query: 567 EAVAICKGLMTKHPGKRLGCGPEGERDIKEHAF 599 K + K+ R + +H F Sbjct: 269 NFKDFLKKCLEKNVDARWTTS-----QLLQHPF 296 >3PPZ-A nrPDB Length = 309 Score = 249 bits (635), Expect = 4e-66, Method: Composition-based stats. Identities = 66/252 (26%), Positives = 127/252 (50%), Gaps = 11/252 (4%) Query: 341 DFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKP 400 D N +G GSFG V +E G+D AVKIL + + V + E ++ + Sbjct: 38 DLNIKEKIGAGSFGTVHRAEWHGSD--VAVKILMEQDFHAER-VNEFLREVAIMKRL-RH 93 Query: 401 PFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVG---RFKEPHAVFYAAEIAIGLFFL 457 P + L V EY++ G L + + G + E + A ++A G+ +L Sbjct: 94 PNIVLFMGAVTQPPNLSIVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAKGMNYL 153 Query: 458 QSKG--IIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAY 515 ++ I++RDLK N+++D + +K+ DFG+ + +++K+ GTP+++APE++ Sbjct: 154 HNRNPPIVHRDLKSPNLLVDKKYTVKVCDFGLSRLKASTFLSSKSAAGTPEWMAPEVLRD 213 Query: 516 QPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSI--MEHNVAYPKSMSKEAVAICK 573 +P + D ++FGV+L+E+ Q P+ + ++ ++ + P++++ + AI + Sbjct: 214 EPSNEKSDVYSFGVILWELATLQQPWGNLNPAQVVAAVGFKCKRLEIPRNLNPQVAAIIE 273 Query: 574 GLMTKHPGKRLG 585 G T P KR Sbjct: 274 GCWTNEPWKRPS 285 >5D7A-A nrPDB Length = 308 Score = 248 bits (633), Expect = 6e-66, Method: Composition-based stats. Identities = 69/291 (23%), Positives = 116/291 (39%), Gaps = 26/291 (8%) Query: 327 KFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVEC 386 + D + RD + F + ++G G++G+V T +L A+K++ + D+ E Sbjct: 6 EIDLSALRDPAGI--FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMD----VTGDEEEE 59 Query: 387 TMVEKRVLALPGKPPFLTQLHSCFQTM------DRLYFVMEYVNGGDLMYHIQ--QVGRF 438 E +L + + F D+L+ VME+ G + I+ + Sbjct: 60 IKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTL 119 Query: 439 KEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTT 498 KE + EI GL L +I+RD+K NV+L +K+ DFG+ + Sbjct: 120 KEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRR 179 Query: 499 KTFCGTPDYIAPEIIAYQ-----PYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSI 553 TF GTP ++APE+IA Y D W+ G+ EM G P I Sbjct: 180 NTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLI 239 Query: 554 MEHNVAY--PKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRY 602 + K SK+ + + + K+ +R + +H F R Sbjct: 240 PRNPAPRLKSKKWSKKFQSFIESCLVKNHSQR-----PATEQLMKHPFIRD 285 >6HXF-B nrPDB Length = 302 Score = 248 bits (633), Expect = 7e-66, Method: Composition-based stats. Identities = 75/270 (27%), Positives = 127/270 (47%), Gaps = 18/270 (6%) Query: 343 NFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPF 402 + LG G+FGKV ++ K T L A K+++ ++++E +VE +LA P+ Sbjct: 22 EIVGELGDGAFGKVYKAKNKETGALAAAKVIETK---SEEELEDYIVEIEILATCD-HPY 77 Query: 403 LTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR-FKEPHAVFYAAEIAIGLFFLQSKG 461 + +L + +L+ ++E+ GG + + ++ R EP ++ L FL SK Sbjct: 78 IVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKR 137 Query: 462 IIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQ----- 516 II+RDLK NV++ EG I++ADFG+ +N+ +F GTP ++APE++ + Sbjct: 138 IIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDT 197 Query: 517 PYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVA---YPKSMSKEAVAICK 573 PY D W+ G+ L EM + P + + I + + P S E K Sbjct: 198 PYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLK 257 Query: 574 GLMTKHPGKRLGCGPEGERDIKEHAFFRYI 603 + K+P R + EH F I Sbjct: 258 IALDKNPETRPSAA-----QLLEHPFVSSI 282 >5YV8-A nrPDB Length = 298 Score = 247 bits (632), Expect = 8e-66, Method: Composition-based stats. Identities = 80/295 (27%), Positives = 131/295 (44%), Gaps = 37/295 (12%) Query: 335 DRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDD----------- 383 D ++L + +GKGS+G V L+ + + YA+K+L K +I+ Sbjct: 8 DCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTR 67 Query: 384 ------------VECTMVEKRVLALPGKPPFLTQLHSCFQT--MDRLYFVMEYVNGGDLM 429 +E E +L P + +L D LY V E VN G +M Sbjct: 68 PAPGGCIQPRGPIEQVYQEIAILKKLD-HPNVVKLVEVLDDPNEDHLYMVFELVNQGPVM 126 Query: 430 YHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCK 489 + + E A FY ++ G+ +L + II+RD+K N+++ +GHIKIADFG+ Sbjct: 127 E-VPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSN 185 Query: 490 ENIWDGVTTKTFCGTPDYIAPEIIAYQP---YGKSVDWWAFGVLLYEMLAGQAPFEGEDE 546 E GTP ++APE ++ GK++D WA GV LY + GQ PF E Sbjct: 186 EFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERI 245 Query: 547 DELFQSIMEHNVAYPK--SMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAF 599 L I + +P ++++ + ++ K+P R+ +IK H + Sbjct: 246 MCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRI-----VVPEIKLHPW 295 >4FZF-B nrPDB Length = 283 Score = 247 bits (632), Expect = 9e-66, Method: Composition-based stats. Identities = 73/278 (26%), Positives = 126/278 (45%), Gaps = 10/278 (3%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 F L +GKGSFG+V T ++ A+KI+ D+ +D++E E VL+ Sbjct: 10 FTKLERIGKGSFGEVFKGIDNRTQQVVAIKII--DLEEAEDEIEDIQQEITVLSQCDSS- 66 Query: 402 FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKG 461 ++T+ + + +L+ +MEY+ GG + ++ G F E EI GL +L S+ Sbjct: 67 YVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRA-GPFDEFQIATMLKEILKGLDYLHSEK 125 Query: 462 IIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKS 521 I+RD+K NV+L +G +K+A FG+ + + TF GTP ++APE+I Y Sbjct: 126 KIHRDIKAANVLLSEQGDVKLAAFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSK 185 Query: 522 VDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHN-VAYPKSMSKEAVAICKGLMTKHP 580 D W+ G+ E+ G+ P + I ++N +K + K P Sbjct: 186 ADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVGDFTKSFKEFIDACLNKDP 245 Query: 581 GKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYK 618 R +++ +H F + E+ +K Sbjct: 246 SFRPTA-----KELLKHKFIVKNSKKTSYLTELIDRFK 278 >1KOB-A nrPDB Length = 387 Score = 247 bits (632), Expect = 9e-66, Method: Composition-based stats. Identities = 74/268 (27%), Positives = 125/268 (46%), Gaps = 17/268 (6%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 ++ L LG G+FG V K T ++ K + + V+ E ++ P Sbjct: 53 YDILEELGSGAFGVVHRCVEKATGRVFVAKFINTPYPLDKYTVKN---EISIMNQL-HHP 108 Query: 402 FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVG-RFKEPHAVFYAAEIAIGLFFLQSK 460 L LH F+ + ++E+++GG+L I + E + Y + GL + Sbjct: 109 KLINLHDAFEDKYEMVLILEFLSGGELFDRIAAEDYKMSEAEVINYMRQACEGLKHMHEH 168 Query: 461 GIIYRDLKLDNVMLDSE--GHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY 518 I++ D+K +N+M +++ +KI DFG+ + D + K T ++ APEI+ +P Sbjct: 169 SIVHLDIKPENIMCETKKASSVKIIDFGLATKLNPDEIV-KVTTATAEFAAPEIVDREPV 227 Query: 519 GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKS----MSKEAVAICKG 574 G D WA GVL Y +L+G +PF GED+ E Q++ + + + +S EA K Sbjct: 228 GFYTDMWAIGVLGYVLLSGLSPFAGEDDLETLQNVKRCDWEFDEDAFSSVSPEAKDFIKN 287 Query: 575 LMTKHPGKRLGCGPEGERDIKEHAFFRY 602 L+ K P KRL D EH + + Sbjct: 288 LLQKEPRKRLT-----VHDALEHPWLKG 310 >5J5T-A nrPDB Length = 370 Score = 247 bits (630), Expect = 1e-65, Method: Composition-based stats. Identities = 76/329 (23%), Positives = 127/329 (38%), Gaps = 17/329 (5%) Query: 340 TDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK 399 DF + +G G++G V + T EL A+K++K ++ + + ++ ++ K Sbjct: 4 EDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIK----LEPGEDFAVVQQEIIMMKDCK 59 Query: 400 PPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQS 459 P + + D+L+ ME+ GG L G E + + E GL++L S Sbjct: 60 HPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHS 119 Query: 460 KGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEII---AYQ 516 KG ++RD+K N++L GH+K+ADFG+ + K F GTP ++APE+ Sbjct: 120 KGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKAFIGTPYWMAPEVAAVERKG 179 Query: 517 PYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPK-----SMSKEAVAI 571 Y + D WA G+ E+ Q P + + N PK S Sbjct: 180 GYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFHHF 239 Query: 572 CKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFD 631 K +TK+P KR + +H F L + + P D + D Sbjct: 240 VKMALTKNPKKRPTA-----EKLLQHPFVTQHLTRSLAIELLDKVNNPDHSTYHDFDDDD 294 Query: 632 KEFTRQPVELTPTDKLFIMNLDQNEFAGF 660 E + + F Sbjct: 295 PEPLVAVPHRIHSTSRNVREEKTRSEITF 323 >4XCU-A nrPDB Length = 300 Score = 247 bits (630), Expect = 1e-65, Method: Composition-based stats. Identities = 76/270 (28%), Positives = 122/270 (45%), Gaps = 25/270 (9%) Query: 334 RDRMKLTDFNFLMVLGKGSFGKVMLSERKGTD-------ELYAVKILKKDVVIQDDDVEC 386 RDR+ L LG+G FG+V+ +E G D AVK+LK + D D+ Sbjct: 16 RDRLVLG-----KPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNA--SDKDLAD 68 Query: 387 TMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQ-------QVGRFK 439 + E V+ L G+ + L LY ++E G+L ++ G Sbjct: 69 LVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGSSEGPLS 128 Query: 440 EPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTK 499 P V A ++A G+ +L+S+ I+RDL NV++ + +KIADFG+ + K Sbjct: 129 FPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKK 188 Query: 500 TFCGTP--DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIME- 555 T G ++APE + + Y D W+FG+LL+E+ G +P+ G +ELF + E Sbjct: 189 TSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREG 248 Query: 556 HNVAYPKSMSKEAVAICKGLMTKHPGKRLG 585 H + P E + + P +R Sbjct: 249 HRMDRPPHCPPELYGLMRECWHAAPSQRPT 278 >4WNO-A nrPDB Length = 287 Score = 246 bits (629), Expect = 2e-65, Method: Composition-based stats. Identities = 78/303 (25%), Positives = 130/303 (42%), Gaps = 34/303 (11%) Query: 311 GQGTKAPEEKTANTISKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKG-TDELYA 369 G G+ P T+ KF +F+ ++G G+F V + D A Sbjct: 1 GGGSMEPGRGGTETVGKF------------EFSRKDLIGHGAFAVVFKGRHRAAHDLEVA 48 Query: 370 VKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLM 429 VK + K + + + E ++L K + L+ + + +Y VMEY NGGDL Sbjct: 49 VKCINKKNLAKSQTL--LGKEIKILK-ELKHENIVALYDFQEMANSVYLVMEYCNGGDLA 105 Query: 430 YHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEG---------HI 480 ++ + E + +IA + L SKGII+RDLK N++L + + Sbjct: 106 DYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRV 165 Query: 481 KIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAP 540 KIADFG + + + T CG+P Y+APE+I Q Y D W+ G ++Y+ L G+AP Sbjct: 166 KIADFGFAR-YLQSNMMAATLCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAP 224 Query: 541 FEGEDEDEL---FQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEH 597 F+ +L ++ P+ S + L+ ++ R+ + H Sbjct: 225 FQASSPQDLRLFYEKNKTLVPTIPRETSAPLRQLLLALLQRNHKDRM-----DFDEFFHH 279 Query: 598 AFF 600 F Sbjct: 280 PFL 282 >1AD5-A nrPDB Length = 438 Score = 246 bits (627), Expect = 3e-65, Method: Composition-based stats. Identities = 72/294 (24%), Positives = 134/294 (45%), Gaps = 32/294 (10%) Query: 296 EGNEELRQKFERAKIGQGTKAPEEKTANTISKFDNNGNRDRMKLTDFNFLMVLGKGSFGK 355 +GN+ L QK + + P EK A I R+ +KL LG G FG+ Sbjct: 150 KGNDGLCQKLSVPCMSSKPQKPWEKDAWEIP-------RESLKLE-----KKLGAGQFGE 197 Query: 356 VMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDR 415 V ++ + AVK +K + VE + E V+ + L +LH+ T + Sbjct: 198 VWMATYNKHTK-VAVKTMKPGSMS----VEAFLAEANVMKTL-QHDKLVKLHAVV-TKEP 250 Query: 416 LYFVMEYVNGGDLMYHIQ--QVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVM 473 +Y + E++ G L+ ++ + + P + ++A+IA G+ F++ + I+RDL+ N++ Sbjct: 251 IYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANIL 310 Query: 474 LDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYE 533 + + KIADFG+ + + + APE I + + D W+FG+LL E Sbjct: 311 VSASLVCKIADFGLARVGAKFPI---------KWTAPEAINFGSFTIKSDVWSFGILLME 361 Query: 534 MLA-GQAPFEGEDEDELFQSIMEH-NVAYPKSMSKEAVAICKGLMTKHPGKRLG 585 ++ G+ P+ G E+ +++ + P++ +E I P +R Sbjct: 362 IVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPEERPT 415 >3UTO-A nrPDB Length = 573 Score = 245 bits (626), Expect = 4e-65, Method: Composition-based stats. Identities = 71/312 (22%), Positives = 139/312 (44%), Gaps = 23/312 (7%) Query: 339 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 398 L ++ LG G+FG V + T +A K + + + D E E + +++ Sbjct: 156 LDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFV---MTPHESDKETVRKEIQTMSVL- 211 Query: 399 KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHI-QQVGRFKEPHAVFYAAEIAIGLFFL 457 + P L LH F+ + + + E+++GG+L + + + E AV Y ++ GL + Sbjct: 212 RHPTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMRQVCKGLCHM 271 Query: 458 QSKGIIYRDLKLDNVMLDSE--GHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAY 515 ++ DLK +N+M ++ +K+ DFG+ ++ + K GT ++ APE+ Sbjct: 272 HENNYVHLDLKPENIMFTTKRSNELKLIDFGL-TAHLDPKQSVKVTTGTAEFAAPEVAEG 330 Query: 516 QPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKS----MSKEAVAI 571 +P G D W+ GVL Y +L+G +PF GE++DE +++ + S +S++ Sbjct: 331 KPVGYYTDMWSVGVLSYILLSGLSPFGGENDDETLRNVKSCDWNMDDSAFSGISEDGKDF 390 Query: 572 CKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFD 631 + L+ P R+ EH + + + + P +R + + Sbjct: 391 IRKLLLADPNTRMTI-----HQALEHPWLTPGNAPGRDSQ------IPSSRYTKIRDSIK 439 Query: 632 KEFTRQPVELTP 643 ++ P L P Sbjct: 440 TKYDAWPEPLPP 451 >1K9A-A nrPDB Length = 450 Score = 245 bits (625), Expect = 5e-65, Method: Composition-based stats. Identities = 73/330 (22%), Positives = 135/330 (40%), Gaps = 27/330 (8%) Query: 278 LSQEEGEYFN--VPVPPEGSEGNEELRQKFERAKIGQGTKAPEEKTANTISKFDNNGNRD 335 LS +E YF + + + + L + + K+ +GT A ++ +F +G Sbjct: 138 LSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTVAAQD-------EFYRSGWAL 190 Query: 336 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 395 MK + L +GKG FG VML + +G AVK +K D + + E V+ Sbjct: 191 NMK--ELKLLQTIGKGEFGDVMLGDYRGNK--VAVKCIKNDATA-----QAFLAEASVMT 241 Query: 396 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR--FKEPHAVFYAAEIAIG 453 + L + LY V EY+ G L+ +++ GR + ++ ++ Sbjct: 242 QLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEA 301 Query: 454 LFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEII 513 + +L+ ++RDL NV++ + K++DFG+ KE T K + APE + Sbjct: 302 MEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPV---KWTAPEAL 358 Query: 514 AYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIMEH-NVAYPKSMSKEAVAI 571 + + D W+FG+LL+E+ + G+ P+ ++ + + + P + Sbjct: 359 REKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDV 418 Query: 572 CKGLMTKHPGKRLGCGP--EGERDIKEHAF 599 K R E I+ H Sbjct: 419 MKNCWHLDAATRPTFLQLREQLEHIRTHEL 448 >4APC-A nrPDB Length = 350 Score = 245 bits (625), Expect = 6e-65, Method: Composition-based stats. Identities = 69/253 (27%), Positives = 116/253 (45%), Gaps = 9/253 (3%) Query: 339 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 398 + + L +G+GSFGK +L + Y +K + + + E + E VLA Sbjct: 23 MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSK-EREESRREVAVLANM- 80 Query: 399 KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHI--QQVGRFKEPHAVFYAAEIAIGLFF 456 K P + Q F+ LY VM+Y GGDL I Q+ F+E + + +I + L Sbjct: 81 KHPNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKH 140 Query: 457 LQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQ 516 + + I++RD+K N+ L +G +++ DFG+ + + GTP Y++PEI + Sbjct: 141 VHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARACIGTPYYLSPEICENK 200 Query: 517 PYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPK---SMSKEAVAICK 573 PY D WA G +LYE+ + FE L I+ ++P S + ++ Sbjct: 201 PYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISG--SFPPVSLHYSYDLRSLVS 258 Query: 574 GLMTKHPGKRLGC 586 L ++P R Sbjct: 259 QLFKRNPRDRPSV 271 >3IS5-A nrPDB Length = 285 Score = 244 bits (623), Expect = 9e-65, Method: Composition-based stats. Identities = 71/271 (26%), Positives = 119/271 (43%), Gaps = 20/271 (7%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 F F LG G+FG V L E + + +K + KD +E E VL P Sbjct: 24 FIFKRKLGSGAFGDVHLVEERSSGLERVIKTINKDRSQVP--MEQIEAEIEVLKSLD-HP 80 Query: 402 FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQ----QVGRFKEPHAVFYAAEIAIGLFFL 457 + ++ F+ +Y VME GG+L+ I + E + ++ L + Sbjct: 81 NIIKIFEVFEDYHNMYIVMETCEGGELLERIVSAQARGKALSEGYVAELMKQMMNALAYF 140 Query: 458 QSKGIIYRDLKLDNVMLDS---EGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA 514 S+ ++++DLK +N++ IKI DFG+ E + GT Y+APE+ Sbjct: 141 HSQHVVHKDLKPENILFQDTSPHSPIKIIDFGLA-ELFKSDEHSTNAAGTALYMAPEVFK 199 Query: 515 YQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQS--IMEHNVAYP-KSMSKEAVAI 571 + D W+ GV++Y +L G PF G +E+ Q E N A + ++ +AV + Sbjct: 200 -RDVTFKCDIWSAGVVMYFLLTGCLPFTGTSLEEVQQKATYKEPNYAVECRPLTPQAVDL 258 Query: 572 CKGLMTKHPGKRLGCGPEGERDIKEHAFFRY 602 K ++TK P +R + H +F+ Sbjct: 259 LKQMLTKDPERRPSAA-----QVLHHEWFKQ 284 >2X4F-A nrPDB Length = 373 Score = 244 bits (623), Expect = 1e-64, Method: Composition-based stats. Identities = 69/264 (26%), Positives = 120/264 (45%), Gaps = 17/264 (6%) Query: 346 MVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQ 405 +LG G FG+V E T A KI+K + ++V+ E V+ L Q Sbjct: 95 EILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKEEVKN---EISVMNQLD-HANLIQ 150 Query: 406 LHSCFQTMDRLYFVMEYVNGGDLMYHI-QQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIY 464 L+ F++ + + VMEYV+GG+L I + E + + +I G+ + I++ Sbjct: 151 LYDAFESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQMYILH 210 Query: 465 RDLKLDNVMLDSEG--HIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSV 522 DLK +N++ + IKI DFG+ + K GTP+++APE++ Y Sbjct: 211 LDLKPENILCVNRDAKQIKIIDFGLARR-YKPREKLKVNFGTPEFLAPEVVNYDFVSFPT 269 Query: 523 DWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPK----SMSKEAVAICKGLMTK 578 D W+ GV+ Y +L+G +PF G+++ E +I+ +S+EA L+ K Sbjct: 270 DMWSVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEFQDISEEAKEFISKLLIK 329 Query: 579 HPGKRLGCGPEGERDIKEHAFFRY 602 R+ + +H + Sbjct: 330 EKSWRISAS-----EALKHPWLSD 348 >2PSQ-A nrPDB Length = 370 Score = 244 bits (623), Expect = 1e-64, Method: Composition-based stats. Identities = 71/279 (25%), Positives = 124/279 (44%), Gaps = 29/279 (10%) Query: 334 RDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDE-------LYAVKILKKDVVIQDDDVEC 386 + LG+G FG+V+++E G D+ AVK+LK D + D+ Sbjct: 75 KWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDAT--EKDLSD 132 Query: 387 TMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQV----------- 435 + E ++ + GK + L LY ++EY + G+L +++ Sbjct: 133 LVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDI 192 Query: 436 GRFKEPHAVF-----YAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKE 490 R E F ++A G+ +L S+ I+RDL NV++ +KIADFG+ ++ Sbjct: 193 NRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARD 252 Query: 491 NIWDGVTTKTFCGTP--DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDED 547 KT G ++APE + + Y D W+FGVL++E+ G +P+ G + Sbjct: 253 INNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVE 312 Query: 548 ELFQSIME-HNVAYPKSMSKEAVAICKGLMTKHPGKRLG 585 ELF+ + E H + P + + E + + P +R Sbjct: 313 ELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPT 351 >1KOA-A nrPDB Length = 491 Score = 243 bits (620), Expect = 2e-64, Method: Composition-based stats. Identities = 71/312 (22%), Positives = 139/312 (44%), Gaps = 23/312 (7%) Query: 339 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 398 L ++ LG G+FG V + T +A K + + + D E E + +++ Sbjct: 50 LDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFV---MTPHESDKETVRKEIQTMSVL- 105 Query: 399 KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHI-QQVGRFKEPHAVFYAAEIAIGLFFL 457 + P L LH F+ + + + E+++GG+L + + + E AV Y ++ GL + Sbjct: 106 RHPTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMRQVCKGLCHM 165 Query: 458 QSKGIIYRDLKLDNVMLDSE--GHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAY 515 ++ DLK +N+M ++ +K+ DFG+ ++ + K GT ++ APE+ Sbjct: 166 HENNYVHLDLKPENIMFTTKRSNELKLIDFGL-TAHLDPKQSVKVTTGTAEFAAPEVAEG 224 Query: 516 QPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKS----MSKEAVAI 571 +P G D W+ GVL Y +L+G +PF GE++DE +++ + S +S++ Sbjct: 225 KPVGYYTDMWSVGVLSYILLSGLSPFGGENDDETLRNVKSCDWNMDDSAFSGISEDGKDF 284 Query: 572 CKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFD 631 + L+ P R+ EH + + + + P +R + + Sbjct: 285 IRKLLLADPNTRMTI-----HQALEHPWLTPGNAPGRDSQ------IPSSRYTKIRDSIK 333 Query: 632 KEFTRQPVELTP 643 ++ P L P Sbjct: 334 TKYDAWPEPLPP 345 >4KRC-A nrPDB Length = 317 Score = 242 bits (619), Expect = 3e-64, Method: Composition-based stats. Identities = 64/302 (21%), Positives = 121/302 (40%), Gaps = 50/302 (16%) Query: 340 TDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK 399 + F L LG G++ V K T A+K +K D ++ T + + L K Sbjct: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLD---SEEGTPSTAIREISLMKELK 61 Query: 400 PPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR------FKEPHAVFYAAEIAIG 453 + +L+ T ++L V E+++ DL ++ + ++ ++ G Sbjct: 62 HENIVRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 Query: 454 LFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEII 513 L F I++RDLK N++++ G +K+ DFG+ + T + T Y AP+++ Sbjct: 121 LAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVL 180 Query: 514 AY-QPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIME----HNVAYPKSMSK-- 566 + Y S+D W+ G +L EM+ G+ F G +++E + I + N + S++K Sbjct: 181 MGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLP 240 Query: 567 ----------------------------EAVAICKGLMTKHPGKRLGCGPEGERDIKEHA 598 + GL+ +P RL + H Sbjct: 241 KYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSA-----KQALHHP 295 Query: 599 FF 600 +F Sbjct: 296 WF 297 >5UE8-A nrPDB Length = 961 Score = 241 bits (616), Expect = 6e-64, Method: Composition-based stats. Identities = 65/267 (24%), Positives = 106/267 (39%), Gaps = 51/267 (19%) Query: 37 HKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSC-----PGADK 91 H F PT+C C +WG +QG +C C H++C + + C + K Sbjct: 39 HNFEVWTATTPTYCYECEGLLWGIARQGMRCTECGVKCHEKCQDLLNADCLQRAAEKSSK 98 Query: 92 GPASDDPRS-----KHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMN 146 A D ++ K + KI + P + L+ + T M K+ V++ Sbjct: 99 HGAEDRTQNIIMVLKDRMKIRERNKPEIFE----LIQEVFAVTKSAHTQQMKAVKQSVLD 154 Query: 147 VPSLCGTDHTERRGRIYIQAHIDREVLIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKS 206 GT + + + V A+ L D G SDPYV +++ Sbjct: 155 -----GTSKWSAK-------------ISITVVCAQGLQAKDKTGSSDPYVTVQV-----G 191 Query: 207 ESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWD---------LTSR--NDF 255 ++K++TKTI +LNP W E F F+ S R+ V +WD D R +DF Sbjct: 192 KTKKRTKTIYGNLNPVWEENFHFECHNSSD--RIKVRVWDEDDDIKSRVKQRFKRESDDF 249 Query: 256 MGSLSFGISELQKAGVDGWFKLLSQEE 282 +G + L +D W+ L + + Sbjct: 250 LGQTIIEVRTL-SGEMDVWYNLDKRTD 275 >4K33-A nrPDB Length = 325 Score = 241 bits (615), Expect = 9e-64, Method: Composition-based stats. Identities = 71/279 (25%), Positives = 124/279 (44%), Gaps = 29/279 (10%) Query: 334 RDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDE-------LYAVKILKKDVVIQDDDVEC 386 + + LG+G+FG+V+++E G D+ AVK+LK D D D+ Sbjct: 30 KWELSRARLTLGKPLGEGAFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDAT--DKDLSD 87 Query: 387 TMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR--------- 437 + E ++ + GK + L LY ++EY G+L ++ Sbjct: 88 LVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDT 147 Query: 438 -------FKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKE 490 V A ++A G+ +L S+ I+RDL NV++ + +KIADFG+ ++ Sbjct: 148 SKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARD 207 Query: 491 NIWDGVTTKTFCGTP--DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDED 547 +T G ++APE + + Y D W+FGVLL+E+ G +P+ G + Sbjct: 208 VHNLDYYKETTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVE 267 Query: 548 ELFQSIME-HNVAYPKSMSKEAVAICKGLMTKHPGKRLG 585 ELF+ + E H + P + + + I + P +R Sbjct: 268 ELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPT 306 >3FXW-A nrPDB Length = 336 Score = 241 bits (614), Expect = 1e-63, Method: Composition-based stats. Identities = 73/279 (26%), Positives = 118/279 (42%), Gaps = 33/279 (11%) Query: 340 TDFNFLM-VLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 398 D+ VLG G GKV+ + T + A+K+L D E Sbjct: 28 DDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLL--------YDSPKARQEVDHHWQAS 79 Query: 399 KPPFLTQLHSCFQTMDR----LYFVMEYVNGGDLMYHIQQVGR--FKEPHAVFYAAEIAI 452 P + + ++ M L +ME + GG+L IQ+ G F E A +I Sbjct: 80 GGPHIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGT 139 Query: 453 GLFFLQSKGIIYRDLKLDNVMLDS---EGHIKIADFGMCKENIWDGVTTKTFCGTPDYIA 509 + FL S I +RD+K +N++ S + +K+ DFG KE + + T C TP Y+A Sbjct: 140 AIQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNALQ--TPCYTPYYVA 197 Query: 510 PEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDEL----FQSIMEHNVAYP---- 561 PE++ + Y KS D W+ GV++Y +L G PF + + I +P Sbjct: 198 PEVLGPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQYGFPNPEW 257 Query: 562 KSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFF 600 +S++A + + L+ P +RL H + Sbjct: 258 SEVSEDAKQLIRLLLKTDPTERLTIT-----QFMNHPWI 291 >4BBM-A nrPDB Length = 331 Score = 241 bits (614), Expect = 1e-63, Method: Composition-based stats. Identities = 74/309 (23%), Positives = 121/309 (39%), Gaps = 41/309 (13%) Query: 339 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 398 + + L ++G+GS+G VM K T + A+K + D V+ + + L Sbjct: 24 MEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLES--DDDKMVKKIAMREIKLLKQL 81 Query: 399 KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQ 458 + L L + R Y V E+V+ L Y +I G+ F Sbjct: 82 RHENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIGFCH 141 Query: 459 SKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQ-P 517 S II+RD+K +N+++ G +K+ DFG + G T Y APE++ Sbjct: 142 SHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYDDEVATRWYRAPELLVGDVK 201 Query: 518 YGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEH--------------------- 556 YGK+VD WA G L+ EM G+ F G+ + + IM Sbjct: 202 YGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGV 261 Query: 557 -----------NVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDW 605 YPK +S+ + + K + P KR C ++ H FF+ + Sbjct: 262 RLPEIKEREPLERRYPK-LSEVVIDLAKKCLHIDPDKRPFCA-----ELLHHDFFQMDGF 315 Query: 606 EKLERKEIQ 614 + +E+Q Sbjct: 316 AERFSQELQ 324 >2HW6-A nrPDB Length = 307 Score = 241 bits (614), Expect = 1e-63, Method: Composition-based stats. Identities = 79/291 (27%), Positives = 127/291 (43%), Gaps = 42/291 (14%) Query: 346 MVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQ 405 +LG+G++ KV + + YAVKI++K V E L + + Sbjct: 19 ELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRV---FREVETLYQCQGNKNILE 75 Query: 406 LHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYR 465 L F+ R Y V E + GG ++ HIQ+ F E A ++A L FL +KGI +R Sbjct: 76 LIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKGIAHR 135 Query: 466 DLKLDNVMLDSEGH---IKIADFGMCKENIWDGV-------TTKTFCGTPDYIAPEII-- 513 DLK +N++ +S +KI DF + + T CG+ +Y+APE++ Sbjct: 136 DLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEV 195 Query: 514 ---AYQPYGKSVDWWAFGVLLYEMLAGQAPFEGE---------------DEDELFQSIME 555 Y K D W+ GV+LY ML+G PF G +++LF+SI E Sbjct: 196 FTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQE 255 Query: 556 HNVAYPK----SMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRY 602 +P +S EA + L+ + +RL + +H + + Sbjct: 256 GKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAA-----QVLQHPWVQG 301 >2H8H-A nrPDB Length = 535 Score = 240 bits (613), Expect = 1e-63, Method: Composition-based stats. Identities = 66/296 (22%), Positives = 122/296 (41%), Gaps = 23/296 (7%) Query: 295 SEGNEELRQKFERAKIGQGTKAPEEKTANTISKFDNNGNRDRMKLTDFNFLMVLGKGSFG 354 S+ + L + + + A + R +K LG+G FG Sbjct: 233 SKHADGLCHRLTTVCPTSKPQT--QGLAKDAWEIPRESLRLEVK---------LGQGCFG 281 Query: 355 KVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMD 414 +V + GT A+K LK + E + E +V+ + L QL++ + + Sbjct: 282 EVWMGTWNGTTR-VAIKTLKPGTMSP----EAFLQEAQVMKKL-RHEKLVQLYAVV-SEE 334 Query: 415 RLYFVMEYVNGGDLMYHIQ--QVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNV 472 +Y V EY++ G L+ ++ + P V AA+IA G+ +++ ++RDL+ N+ Sbjct: 335 PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANI 394 Query: 473 MLDSEGHIKIADFGMCKENIWDGVTTKTFCGTP-DYIAPEIIAYQPYGKSVDWWAFGVLL 531 ++ K+ADFG+ + + T + P + APE Y + D W+FG+LL Sbjct: 395 LVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILL 454 Query: 532 YEMLA-GQAPFEGEDEDELFQSIMEH-NVAYPKSMSKEAVAICKGLMTKHPGKRLG 585 E+ G+ P+ G E+ + + P + + K P +R Sbjct: 455 TELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPT 510 >3V5Q-A nrPDB Length = 297 Score = 240 bits (612), Expect = 2e-63, Method: Composition-based stats. Identities = 67/275 (24%), Positives = 113/275 (41%), Gaps = 29/275 (10%) Query: 337 MKLTDFNFLMVLGKGSFGKVMLSE-----RKGTDELYAVKILKKDVVIQDDDVECTMVEK 391 +K D LG+G+FGKV L+E L AVK LK + D + E Sbjct: 12 IKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQ---REA 68 Query: 392 RVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR-------------- 437 +L + + + + D L V EY+ GDL ++ G Sbjct: 69 ELLT-NLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAK 127 Query: 438 --FKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDG 495 + A++IA G+ +L S+ ++RDL N ++ + +KI DFGM ++ Sbjct: 128 GELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTD 187 Query: 496 VTT--KTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQS 552 ++ PE I Y+ + D W+FGV+L+E+ G+ P+ E+ + Sbjct: 188 YYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIEC 247 Query: 553 IMEHN-VAYPKSMSKEAVAICKGLMTKHPGKRLGC 586 I + + P+ KE + G + P +RL Sbjct: 248 ITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNI 282 >6F3F-A nrPDB Length = 455 Score = 240 bits (612), Expect = 2e-63, Method: Composition-based stats. Identities = 66/296 (22%), Positives = 122/296 (41%), Gaps = 23/296 (7%) Query: 295 SEGNEELRQKFERAKIGQGTKAPEEKTANTISKFDNNGNRDRMKLTDFNFLMVLGKGSFG 354 S+ + L + + + A + R +K LG+G FG Sbjct: 153 SKHADGLCHRLTTVCPTSKPQT--QGLAKDAWEIPRESLRLEVK---------LGQGCFG 201 Query: 355 KVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMD 414 +V + GT A+K LK + E + E +V+ + L QL++ + + Sbjct: 202 EVWMGTWNGTTR-VAIKTLKPGTMSP----EAFLQEAQVMKKL-RHEKLVQLYAVV-SEE 254 Query: 415 RLYFVMEYVNGGDLMYHIQ--QVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNV 472 +Y V EY+N G L+ ++ + P V +A+IA G+ +++ ++RDL+ N+ Sbjct: 255 PIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVERMNYVHRDLRAANI 314 Query: 473 MLDSEGHIKIADFGMCKENIWDGVTTKTFCGTP-DYIAPEIIAYQPYGKSVDWWAFGVLL 531 ++ K+ADFG+ + + T + P + APE Y + D W+FG+LL Sbjct: 315 LVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILL 374 Query: 532 YEMLA-GQAPFEGEDEDELFQSIMEH-NVAYPKSMSKEAVAICKGLMTKHPGKRLG 585 E+ G+ P+ G E+ + + P + + K P +R Sbjct: 375 TELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPT 430 >6GQK-A nrPDB Length = 328 Score = 239 bits (611), Expect = 2e-63, Method: Composition-based stats. Identities = 67/279 (24%), Positives = 111/279 (39%), Gaps = 28/279 (10%) Query: 333 NRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDE-----LYAVKILKKDVVIQDDDVECT 387 ++ +F LG G+FGKV+ + +G + AVK+LK + E Sbjct: 34 HKWEFPRNRLSFGKTLGAGAFGKVVEATAQGLIKSDAAMTVAVKMLKPSA--HSTEREAL 91 Query: 388 MVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR---------- 437 M E +VL+ G + L + EY GDL+ +++ Sbjct: 92 MSELKVLSYLGNHENIVNLLGACTHGGPTLVITEYCCYGDLLNFLRRKRDEFVPYKVAPE 151 Query: 438 ------FKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKEN 491 H + ++ ++A G+ FL SK I+RDL N++L KI DFG+ ++ Sbjct: 152 DLYKDFLTLEHLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGNITKICDFGLARDI 211 Query: 492 IWDGVTTKTFCGTP--DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDE 548 D ++APE I Y D W++G+ L+E+ + G +P+ G D Sbjct: 212 KNDSNYVDKGNARLPVKWMAPESIFNSVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDS 271 Query: 549 LFQSIMEHNVAY--PKSMSKEAVAICKGLMTKHPGKRLG 585 F +++ P+ E I K P KR Sbjct: 272 KFYKMIKEGFRMSSPEYAPAEMYDIMKTCWDADPDKRPT 310 >6QAU-A nrPDB Length = 280 Score = 239 bits (610), Expect = 3e-63, Method: Composition-based stats. Identities = 71/284 (25%), Positives = 127/284 (44%), Gaps = 22/284 (7%) Query: 332 GNRDRMKLTDFNFLMVLGKGSFGKVMLSERK-GTDELYAVKILKKDVVIQDDDVECTMVE 390 G+ + + +++ ++G G+F V + TD A+K + K + + + + + Sbjct: 3 GSMEVVGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKS---QILLGK 59 Query: 391 KRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEI 450 + + + + L+ + + ++ VMEY NGGDL ++Q G E + +I Sbjct: 60 EIKILKELQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQI 119 Query: 451 AIGLFFLQSKGIIYRDLKLDNVMLD---------SEGHIKIADFGMCKENIWDGVTTKTF 501 A + L SKGII+RDLK N++L S IKIADFG + + + Sbjct: 120 AAAMRILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFAR-YLHSNMMAADL 178 Query: 502 CGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDEL---FQSIMEHNV 558 CG+P Y+APE+I Q Y D W+ G ++Y+ L G+ PF+ +L ++ Sbjct: 179 CGSPMYMAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMP 238 Query: 559 AYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRY 602 + P+ S + GL+ ++ R+ H F Sbjct: 239 SIPRETSPYLANLLLGLLQRNQKDRM-----DFEAFFSHPFLEQ 277 >1FVR-A nrPDB Length = 327 Score = 239 bits (610), Expect = 3e-63, Method: Composition-based stats. Identities = 66/267 (24%), Positives = 118/267 (44%), Gaps = 25/267 (9%) Query: 340 TDFNFLMVLGKGSFGKVMLSERKGTDELY--AVKILKKDVVIQDDDVECTMVEKRVLALP 397 D F V+G+G+FG+V+ + K A+K +K+ DD E VL Sbjct: 25 NDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKE--YASKDDHRDFAGELEVLCKL 82 Query: 398 GKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEP---------------- 441 G P + L + LY +EY G+L+ +++ + Sbjct: 83 GHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQ 142 Query: 442 HAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTF 501 + +AA++A G+ +L K I+RDL N+++ KIADFG+ + + KT Sbjct: 143 QLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSR--GQEVYVKKTM 200 Query: 502 CGTP-DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIMEH-NV 558 P ++A E + Y Y + D W++GVLL+E+++ G P+ G EL++ + + + Sbjct: 201 GRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRL 260 Query: 559 AYPKSMSKEAVAICKGLMTKHPGKRLG 585 P + E + + + P +R Sbjct: 261 EKPLNCDDEVYDLMRQCWREKPYERPS 287 >4AT3-A nrPDB Length = 299 Score = 238 bits (608), Expect = 6e-63, Method: Composition-based stats. Identities = 63/269 (23%), Positives = 111/269 (41%), Gaps = 26/269 (9%) Query: 337 MKLTDFNFLMVLGKGSFGKVMLSERKG-----TDELYAVKILKKDVVIQDDDVECTMVEK 391 +K + LG+G+FGKV L+E L AVK LK D+ + E Sbjct: 10 IKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKD---ASDNARKDFHREA 66 Query: 392 RVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR-------------F 438 +L + + + + D L V EY+ GDL ++ G Sbjct: 67 ELLT-NLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTEL 125 Query: 439 KEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTT 498 + + A +IA G+ +L S+ ++RDL N ++ +KI DFGM ++ Sbjct: 126 TQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYR 185 Query: 499 --KTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIME 555 ++ PE I Y+ + D W+ GV+L+E+ G+ P+ +E+ + I + Sbjct: 186 VGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQ 245 Query: 556 HN-VAYPKSMSKEAVAICKGLMTKHPGKR 583 + P++ +E + G + P R Sbjct: 246 GRVLQRPRTCPQEVYELMLGCWQREPHMR 274 >4U41-A nrPDB Length = 332 Score = 237 bits (605), Expect = 1e-62, Method: Composition-based stats. Identities = 71/302 (23%), Positives = 124/302 (41%), Gaps = 26/302 (8%) Query: 316 APEEKTANTISKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKK 375 + + A ++ D + RD + F + V+G G++G+V T +L A+K++ Sbjct: 2 SANDSPAKSLVDIDLSSLRDPAGI--FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMD- 58 Query: 376 DVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTM------DRLYFVMEYVNGGDLM 429 + +D+ E +E +L + + F D+L+ VME+ G + Sbjct: 59 ---VTEDEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSIT 115 Query: 430 YHIQ--QVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGM 487 ++ + KE + + EI GL L +I+RD+K NV+L +K+ DFG+ Sbjct: 116 DLVKNTKGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGV 175 Query: 488 CKENIWDGVTTKTFCGTPDYIAPEIIAYQ-----PYGKSVDWWAFGVLLYEMLAGQAPFE 542 + TF GTP ++APE+IA Y D W+ G+ EM G P Sbjct: 176 SAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLC 235 Query: 543 GEDEDELFQSIMEHNVAY--PKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFF 600 I + K SK+ + +G + K+ +R + +H F Sbjct: 236 DMHPMRALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPST-----EQLLKHPFI 290 Query: 601 RY 602 R Sbjct: 291 RD 292 >5EG3-A nrPDB Length = 334 Score = 237 bits (605), Expect = 1e-62, Method: Composition-based stats. Identities = 69/279 (24%), Positives = 124/279 (44%), Gaps = 29/279 (10%) Query: 334 RDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDE-------LYAVKILKKDVVIQDDDVEC 386 + LG+G+FG+V+++E G D+ AVK+LK D + D+ Sbjct: 29 KWEFPRDKLTLGKPLGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDAT--EKDLSD 86 Query: 387 TMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQV----------- 435 + E ++ + GK + L LY ++ Y + G+L +++ Sbjct: 87 LVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVAYASKGNLREYLRARRPPGMELSPDI 146 Query: 436 GRFKEPHAVF-----YAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKE 490 R E F ++A G+ +L S+ I+RDL NV++ +KIADFG+ ++ Sbjct: 147 NRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARD 206 Query: 491 NIWDGVTTKTFCGTP--DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDED 547 +T G ++APE + + Y D W+FGVL++E+ G +P+ G + Sbjct: 207 INNIDFFKETTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVE 266 Query: 548 ELFQSIME-HNVAYPKSMSKEAVAICKGLMTKHPGKRLG 585 ELF+ + E H + P + + E + + P +R Sbjct: 267 ELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPT 305 >2HK5-A nrPDB Length = 270 Score = 237 bits (604), Expect = 1e-62, Method: Composition-based stats. Identities = 69/276 (25%), Positives = 129/276 (46%), Gaps = 24/276 (8%) Query: 315 KAPEEKTANTISKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILK 374 + P EK A I R+ +KL LG G FG+V ++ + AVK +K Sbjct: 2 QKPWEKDAWEIP-------RESLKLE-----KKLGAGQFGEVWMATYNKHTK-VAVKTMK 48 Query: 375 KDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQ- 433 + VE + E V+ + L +LH+ T + +Y + E++ G L+ ++ Sbjct: 49 PGSMS----VEAFLAEANVMKTL-QHDKLVKLHAVV-TKEPIYIITEFMAKGSLLDFLKS 102 Query: 434 -QVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENI 492 + + P + ++A+IA G+ F++ + I+RDL+ N+++ + KIADFG+ + Sbjct: 103 DEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIE 162 Query: 493 WDGVTTKTFCGTP-DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELF 550 + T + P + APE I + + D W+FG+LL E++ G+ P+ G E+ Sbjct: 163 DNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVI 222 Query: 551 QSIMEH-NVAYPKSMSKEAVAICKGLMTKHPGKRLG 585 +++ + P++ +E I P +R Sbjct: 223 RALERGYRMPRPENCPEELYNIMMRCWKNRPEERPT 258 >3OZ6-A nrPDB Length = 388 Score = 237 bits (604), Expect = 2e-62, Method: Composition-based stats. Identities = 83/399 (20%), Positives = 145/399 (36%), Gaps = 89/399 (22%) Query: 332 GNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEK 391 G DR L + + LGKG++G V S + T E+ AVK + D D + T E Sbjct: 1 GRVDRHVLRKYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIF-DAFQNSTDAQRTFREI 59 Query: 392 RVLALPGKPPFLTQLHSCFQTMDR--LYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAE 449 +L + L + + + +Y V +Y+ DL I+ + H + + Sbjct: 60 MILTELSGHENIVNLLNVLRADNDRDVYLVFDYMET-DLHAVIRA-NILEPVHKQYVVYQ 117 Query: 450 IAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENI----------------- 492 + + +L S G+++RD+K N++L++E H+K+ADFG+ + + Sbjct: 118 LIKVIKYLHSGGLLHRDMKPSNILLNAECHVKVADFGLSRSFVNIRRVTNNIPLSINENT 177 Query: 493 ----WDGVTTKTFCGTPDYIAPEIIAYQ-PYGKSVDWWAFGVLLYEMLAGQAPFEGEDED 547 D + T Y APEI+ Y K +D W+ G +L E+L G+ F G Sbjct: 178 ENFDDDQPILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGKPIFPGSSTM 237 Query: 548 ELFQSIMEHNVAYPKS-------------------------------------------- 563 + I+ + +P + Sbjct: 238 NQLERII-GVIDFPSNEDVESIQSPFAKTMIESLKEKVEIRQSNKRDIFTKWKNLLLKIN 296 Query: 564 ----MSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAF---FRYIDWEKLERKEIQPP 616 ++EA+ + L+ +P KR+ D +H F F + E I P Sbjct: 297 PKADCNEEALDLLDKLLQFNPNKRISA-----NDALKHPFVSIFHNPNEEPNCDHIITIP 351 Query: 617 YKPKARDKRDTSNFDKEFTRQPVELTPTDKLFIMNLDQN 655 + + D E++ + I N QN Sbjct: 352 INDNVKH-----SIDDYRNLVYSEISRRKRELISNKHQN 385 >4UY9-A nrPDB Length = 323 Score = 237 bits (604), Expect = 2e-62, Method: Composition-based stats. Identities = 76/286 (26%), Positives = 121/286 (42%), Gaps = 22/286 (7%) Query: 332 GNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQ-DDDVECTMVE 390 G + + ++G G FGKV + G AVK + D +E E Sbjct: 1 GQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGD--EVAVKAARHDPDEDISQTIENVRQE 58 Query: 391 KRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEI 450 ++ A+ K P + L L VME+ GG L + R V +A +I Sbjct: 59 AKLFAML-KHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVL-SGKRIPPDILVNWAVQI 116 Query: 451 AIGLFFLQSK---GIIYRDLKLDNVMLD--------SEGHIKIADFGMCKENIWDGVTTK 499 A G+ +L + II+RDLK N+++ S +KI DFG+ +E W T Sbjct: 117 ARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLARE--WHRTTKM 174 Query: 500 TFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVA 559 + GT ++APE+I + K D W++GVLL+E+L G+ PF G D + + + +A Sbjct: 175 SAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLA 234 Query: 560 --YPKSMSKEAVAICKGLMTKHPGKR--LGCGPEGERDIKEHAFFR 601 P + + + + P R + I+E FF Sbjct: 235 LPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFE 280 >4AN9-A nrPDB Length = 301 Score = 237 bits (604), Expect = 2e-62, Method: Composition-based stats. Identities = 67/277 (24%), Positives = 124/277 (44%), Gaps = 13/277 (4%) Query: 336 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 395 +K DF + LG G+ G V K + + A K++ ++ + ++ + + Sbjct: 5 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEI---KPAIRNQIIRELQVL 61 Query: 396 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 455 P++ + F + + ME+++GG L +++ GR E + + GL Sbjct: 62 HECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLT 121 Query: 456 FL-QSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA 514 +L + I++RD+K N++++S G IK+ DFG+ + I F GT Y++PE + Sbjct: 122 YLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLI--DEMANEFVGTRSYMSPERLQ 179 Query: 515 YQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIM-EHNVAYPKSM-SKEAVAIC 572 Y D W+ G+ L EM G+ P EL I+ E P ++ S E Sbjct: 180 GTHYSVQSDIWSMGLSLVEMAVGRYPRPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFV 239 Query: 573 KGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLE 609 + K+P +R + + HAF + D E+++ Sbjct: 240 NKCLIKNPAERA-----DLKQLMVHAFIKRSDAEEVD 271 >2DQ7-X nrPDB Length = 283 Score = 236 bits (603), Expect = 2e-62, Method: Composition-based stats. Identities = 63/258 (24%), Positives = 119/258 (46%), Gaps = 12/258 (4%) Query: 333 NRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKR 392 + + + LG G FG+V + G + A+K LK + + +E E + Sbjct: 2 DVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTK-VAIKTLKPGTMSPESFLE----EAQ 56 Query: 393 VLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQ--QVGRFKEPHAVFYAAEI 450 ++ K L QL++ + + +Y V EY+N G L+ ++ + K P+ V AA++ Sbjct: 57 IMKKL-KHDKLVQLYAVV-SEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQV 114 Query: 451 AIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTP-DYIA 509 A G+ +++ I+RDL+ N+++ + KIADFG+ + + T + P + A Sbjct: 115 AAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTA 174 Query: 510 PEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIMEH-NVAYPKSMSKE 567 PE Y + D W+FG+LL E++ G+ P+ G + E+ + + + P+ Sbjct: 175 PEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPIS 234 Query: 568 AVAICKGLMTKHPGKRLG 585 + K P +R Sbjct: 235 LHELMIHCWKKDPEERPT 252 >3DAK-A nrPDB Length = 290 Score = 236 bits (602), Expect = 2e-62, Method: Composition-based stats. Identities = 67/296 (22%), Positives = 120/296 (40%), Gaps = 32/296 (10%) Query: 331 NGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVE 390 + + D+ V+G G+ V + E A+K + + D + E Sbjct: 1 SALPWSINRDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMD--ELLKE 58 Query: 391 KRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHI--------QQVGRFKEPH 442 + ++ P + ++ F D L+ VM+ ++GG ++ I + G E Sbjct: 59 IQAMSQC-HHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDEST 117 Query: 443 AVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTT---- 498 E+ GL +L G I+RD+K N++L +G ++IADFG+ G T Sbjct: 118 IATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKV 177 Query: 499 -KTFCGTPDYIAPEIIAY-QPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEH 556 KTF GTP ++APE++ + Y D W+FG+ E+ G AP+ ++ +++ Sbjct: 178 RKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQN 237 Query: 557 NV----------AYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRY 602 + K K + + K P KR ++ H FF+ Sbjct: 238 DPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAA-----ELLRHKFFQK 288 >3A4O-X nrPDB Length = 286 Score = 236 bits (602), Expect = 2e-62, Method: Composition-based stats. Identities = 68/276 (24%), Positives = 128/276 (46%), Gaps = 25/276 (9%) Query: 316 APEEKTANTISKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKK 375 P +K A I R+ +KL + LG G FG+V + + + AVK LK Sbjct: 1 KPWDKDAWEIP-------RESIKL-----VKRLGAGQFGEVWMGYYNNSTK-VAVKTLKP 47 Query: 376 DVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQ-- 433 + V+ + E ++ + L +L++ + +Y + EY+ G L+ ++ Sbjct: 48 GTMS----VQAFLEEANLMKTL-QHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSD 102 Query: 434 QVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIW 493 + G+ P + ++A+IA G+ +++ K I+RDL+ NV++ KIADFG+ + Sbjct: 103 EGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIED 162 Query: 494 DGVTTKTFCGTP-DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQ 551 + T + P + APE I + + D W+FG+LLYE++ G+ P+ G ++ Sbjct: 163 NEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMT 222 Query: 552 SIMEHNVAYP--KSMSKEAVAICKGLMTKHPGKRLG 585 ++ + P ++ E I K + +R Sbjct: 223 ALSQG-YRMPRVENCPDELYDIMKMCWKEKAEERPT 257 >6CKI-A nrPDB Length = 316 Score = 236 bits (601), Expect = 3e-62, Method: Composition-based stats. Identities = 79/290 (27%), Positives = 126/290 (43%), Gaps = 42/290 (14%) Query: 347 VLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQL 406 VLG+G+ +V T + YAVKI++K V E +L + +L Sbjct: 20 VLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRV---FREVEMLYQCQGHRNVLEL 76 Query: 407 HSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRD 466 F+ DR Y V E + GG ++ HI + F E A ++A L FL +KGI +RD Sbjct: 77 IEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHNKGIAHRD 136 Query: 467 LKLDNVMLDSEGH---IKIADFGMCKENIWDGVTTK-------TFCGTPDYIAPEII--- 513 LK +N++ + +KI DFG+ +G + T CG+ +Y+APE++ Sbjct: 137 LKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEAF 196 Query: 514 --AYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDE---------------LFQSIMEH 556 Y K D W+ GV+LY +L+G PF G + LF+SI E Sbjct: 197 SEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQNMLFESIQEG 256 Query: 557 NVAYPK----SMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRY 602 +P +S A + L+ + +RL + +H + + Sbjct: 257 KYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAA-----QVLQHPWVQG 301 >2XNP-A nrPDB Length = 279 Score = 236 bits (601), Expect = 3e-62, Method: Composition-based stats. Identities = 72/273 (26%), Positives = 114/273 (41%), Gaps = 19/273 (6%) Query: 340 TDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK 399 D+ L +G GS+G+ RK ++ K L + + + + + E +L K Sbjct: 6 EDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMT-EAEKQMLVSEVNLL-RELK 63 Query: 400 PPFLTQLHSCF--QTMDRLYFVMEYVNGGDLMYHI----QQVGRFKEPHAVFYAAEIAIG 453 P + + + +T LY VMEY GGDL I ++ E + ++ + Sbjct: 64 HPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLA 123 Query: 454 LFFLQS-----KGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYI 508 L +++RDLK NV LD + ++K+ DFG+ + D KTF GTP Y+ Sbjct: 124 LKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYM 183 Query: 509 APEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNV-AYPKSMSKE 567 +PE + Y + D W+ G LLYE+ A PF + EL I E P S E Sbjct: 184 SPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDE 243 Query: 568 AVAICKGLMTKHPGKRLGCGPEGERDIKEHAFF 600 I ++ R +I E+ Sbjct: 244 LNEIITRMLNLKDYHRPS-----VEEILENPLI 271 >2WQN-A nrPDB Length = 310 Score = 236 bits (601), Expect = 4e-62, Method: Composition-based stats. Identities = 64/281 (22%), Positives = 114/281 (40%), Gaps = 11/281 (3%) Query: 311 GQGTKAPEEKTANTISKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAV 370 QG + P + + L +F +G+G F +V + A+ Sbjct: 5 SQGMQGPPVPQFQPQKALRPDMGYN--TLANFRIEKKIGRGQFSEVYRAACLLDGVPVAL 62 Query: 371 KILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMY 430 K ++ ++ + E +L P + + ++ F + L V+E + GDL Sbjct: 63 KKVQIFDLMDAKARADCIKEIDLLKQLN-HPNVIKYYASFIEDNELNIVLELADAGDLSR 121 Query: 431 HIQQVGR----FKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFG 486 I+ + E Y ++ L + S+ +++RD+K NV + + G +K+ D G Sbjct: 122 MIKHFKKQKRLIPERTVWKYFVQLCSALEHMHSRRVMHRDIKPANVFITATGVVKLGDLG 181 Query: 487 MCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEG--E 544 + + + GTP Y++PE I Y D W+ G LLYEM A Q+PF G Sbjct: 182 LGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKM 241 Query: 545 DEDELFQSIMEHNV-AYP-KSMSKEAVAICKGLMTKHPGKR 583 + L + I + + P S+E + + P KR Sbjct: 242 NLYSLCKKIEQCDYPPLPSDHYSEELRQLVNMCINPDPEKR 282 >4E93-A nrPDB Length = 377 Score = 235 bits (600), Expect = 4e-62, Method: Composition-based stats. Identities = 64/278 (23%), Positives = 117/278 (42%), Gaps = 8/278 (2%) Query: 313 GTKAPEEKTANTISKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKI 372 T+ P K + + ++ + D +G+G+FG+V + + L AVK Sbjct: 87 STQQPLTKKSGVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKS 146 Query: 373 LKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHI 432 ++ + D + E R+L P + +L +Y VME V GGD + + Sbjct: 147 CRE--TLPPDLKAKFLQEARILKQYS-HPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFL 203 Query: 433 QQVG-RFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKEN 491 + G R + + + A G+ +L+SK I+RDL N ++ + +KI+DFGM +E Sbjct: 204 RTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREE 263 Query: 492 IWDGVTTKTFC--GTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDE 548 + APE + Y Y D W+FG+LL+E + G +P+ + Sbjct: 264 ADGVYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQ 323 Query: 549 LFQSIME-HNVAYPKSMSKEAVAICKGLMTKHPGKRLG 585 + + + + P+ + + PG+R Sbjct: 324 TREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPS 361 >2Y6O-A nrPDB Length = 291 Score = 235 bits (600), Expect = 4e-62, Method: Composition-based stats. Identities = 60/266 (22%), Positives = 107/266 (40%), Gaps = 15/266 (5%) Query: 330 NNGNRDRMKLTD---FNFLMVLGKGSFGKVMLSERKGTDE---LYAVKILKKDVVIQDDD 383 N R+ K D V+G G FG+V K + A+K LK D Sbjct: 1 NQAVREFAKEIDASCIKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYT--DKQ 58 Query: 384 VECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQV-GRFKEPH 442 + E ++ P + L + + EY+ G L +++ GRF Sbjct: 59 RRDFLSEASIMGQFD-HPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQ 117 Query: 443 AVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFC 502 V I G+ +L ++RDL N++++S K++DFGM + D T Sbjct: 118 LVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTR 177 Query: 503 G---TPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIMEH-N 557 G + APE IAY+ + + D W++G++++E+++ G+ P+ ++ ++I E Sbjct: 178 GGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYR 237 Query: 558 VAYPKSMSKEAVAICKGLMTKHPGKR 583 + P + K R Sbjct: 238 LPPPMDCPIALHQLMLDCWQKERSDR 263 >1NY3-A nrPDB Length = 400 Score = 235 bits (600), Expect = 5e-62, Method: Composition-based stats. Identities = 74/280 (26%), Positives = 118/280 (42%), Gaps = 32/280 (11%) Query: 339 LTDFNFL-MVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALP 397 + D+ VLG G GKV+ K T E +A+K+L D E + Sbjct: 60 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML--------QDCPKARREVELHWRA 111 Query: 398 GKPPFLTQLHSCFQT----MDRLYFVMEYVNGGDLMYHIQQVGR--FKEPHAVFYAAEIA 451 + P + ++ ++ L VME ++GG+L IQ G F E A I Sbjct: 112 SQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIG 171 Query: 452 IGLFFLQSKGIIYRDLKLDNVMLDS---EGHIKIADFGMCKENIWDGVTTKTFCGTPDYI 508 + +L S I +RD+K +N++ S +K+ DFG KE T T C TP Y+ Sbjct: 172 EAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLT-TPCYTPYYV 230 Query: 509 APEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDEL----FQSIMEHNVAYP--- 561 APE++ + Y KS D W+ GV++Y +L G PF + I +P Sbjct: 231 APEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPE 290 Query: 562 -KSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFF 600 +S+E + + L+ P +R+ + H + Sbjct: 291 WSEVSEEVKMLIRNLLKTEPTQRMTIT-----EFMNHPWI 325 >5KMM-A nrPDB Length = 329 Score = 235 bits (600), Expect = 5e-62, Method: Composition-based stats. Identities = 63/274 (22%), Positives = 108/274 (39%), Gaps = 28/274 (10%) Query: 337 MKLTDFNFLMVLGKGSFGKVMLSERKG-----TDELYAVKILKKDVVIQDDDVECTMVEK 391 +K D LG+G+FGKV L+E L AVK LK+ + + E Sbjct: 32 IKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKE---ASESARQDFQREA 88 Query: 392 RVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR-------------- 437 +L + + + + L V EY+ GDL ++ G Sbjct: 89 ELLTML-QHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPG 147 Query: 438 -FKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGV 496 + A+++A G+ +L ++RDL N ++ +KI DFGM ++ Sbjct: 148 PLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDY 207 Query: 497 TTKTFCGTP--DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSI 553 ++ PE I Y+ + D W+FGV+L+E+ G+ P+ E I Sbjct: 208 YRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCI 267 Query: 554 MEH-NVAYPKSMSKEAVAICKGLMTKHPGKRLGC 586 + + P++ E AI +G + P +R Sbjct: 268 TQGRELERPRACPPEVYAIMRGCWQREPQQRHSI 301 >2PL0-A nrPDB Length = 289 Score = 235 bits (600), Expect = 5e-62, Method: Composition-based stats. Identities = 67/279 (24%), Positives = 125/279 (44%), Gaps = 24/279 (8%) Query: 312 QGTKAPEEKTANTISKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVK 371 Q + P + + R+ +KL + LG G FG+V + G + AVK Sbjct: 7 QKPQKPWWEDEWEVP-------RETLKL-----VERLGAGQFGEVWMGYYNGHTK-VAVK 53 Query: 372 ILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYH 431 LK+ + D + E ++ + L +L++ T + +Y + EY+ G L+ Sbjct: 54 SLKQGSMSPDA----FLAEANLMKQL-QHQRLVRLYAVV-TQEPIYIITEYMENGSLVDF 107 Query: 432 IQQVG--RFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCK 489 ++ + + AA+IA G+ F++ + I+RDL+ N+++ KIADFG+ + Sbjct: 108 LKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLAR 167 Query: 490 ENIWDGVTTKTFCGTP-DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDED 547 + T + P + APE I Y + D W+FG+LL E++ G+ P+ G Sbjct: 168 LIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNP 227 Query: 548 ELFQSIMEH-NVAYPKSMSKEAVAICKGLMTKHPGKRLG 585 E+ Q++ + P + +E + + + P R Sbjct: 228 EVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPT 266 >3QGY-A nrPDB Length = 286 Score = 235 bits (599), Expect = 6e-62, Method: Composition-based stats. Identities = 64/248 (25%), Positives = 115/248 (46%), Gaps = 10/248 (4%) Query: 340 TDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK 399 ++ F+ +G G FG V L D+ A+K +K+ + +DD +E E V+ Sbjct: 27 SELTFVQEIGSGQFGLVHLGYWLNKDK-VAIKTIKEGSMSEDDFIE----EAEVMMKLS- 80 Query: 400 PPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQ-QVGRFKEPHAVFYAAEIAIGLFFLQ 458 P L QL+ + V E++ G L +++ Q G F + ++ G+ +L+ Sbjct: 81 HPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLE 140 Query: 459 SKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTP-DYIAPEIIAYQP 517 +I+RDL N ++ IK++DFGM + + D T+ T P + +PE+ ++ Sbjct: 141 EACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSR 200 Query: 518 YGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIMEH-NVAYPKSMSKEAVAICKGL 575 Y D W+FGVL++E+ + G+ P+E E+ + I + P+ S I Sbjct: 201 YSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHC 260 Query: 576 MTKHPGKR 583 + P R Sbjct: 261 WKERPEDR 268 >2OZA-A nrPDB Length = 356 Score = 234 bits (597), Expect = 8e-62, Method: Composition-based stats. Identities = 74/280 (26%), Positives = 118/280 (42%), Gaps = 32/280 (11%) Query: 339 LTDFNFL-MVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALP 397 + D+ VLG G GKV+ K T E +A+K+L D E + Sbjct: 16 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML--------QDCPKARREVELHWRA 67 Query: 398 GKPPFLTQLHSCFQT----MDRLYFVMEYVNGGDLMYHIQQVGR--FKEPHAVFYAAEIA 451 + P + ++ ++ L VME ++GG+L IQ G F E A I Sbjct: 68 SQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIG 127 Query: 452 IGLFFLQSKGIIYRDLKLDNVMLDS---EGHIKIADFGMCKENIWDGVTTKTFCGTPDYI 508 + +L S I +RD+K +N++ S +K+ DFG KE T T C TP Y+ Sbjct: 128 EAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLT-TPCYTPYYV 186 Query: 509 APEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDEL----FQSIMEHNVAYP--- 561 APE++ + Y KS D W+ GV++Y +L G PF + I +P Sbjct: 187 APEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPE 246 Query: 562 -KSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFF 600 +S+E + + L+ P +R+ + H + Sbjct: 247 WSEVSEEVKMLIRNLLKTEPTQRMTIT-----EFMNHPWI 281 >4P5Q-A nrPDB Length = 361 Score = 234 bits (596), Expect = 1e-61, Method: Composition-based stats. Identities = 56/257 (21%), Positives = 109/257 (42%), Gaps = 12/257 (4%) Query: 336 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDEL---YAVKILKKDVVIQDDDVECTMVEKR 392 + T+ + V+G G FG+V K + A+K LK V + + E Sbjct: 29 ELDATNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLK--VGYTEKQRRDFLGEAS 86 Query: 393 VLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVG-RFKEPHAVFYAAEIA 451 ++ P + +L + V EY+ G L +++ +F V IA Sbjct: 87 IMGQFD-HPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIA 145 Query: 452 IGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCG---TPDYI 508 G+ +L G ++RDL N++++S K++DFG+ + D T G + Sbjct: 146 SGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWT 205 Query: 509 APEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIMEH-NVAYPKSMSK 566 +PE IAY+ + + D W++G++L+E+++ G+ P+ ++ +++ E + P Sbjct: 206 SPEAIAYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCPA 265 Query: 567 EAVAICKGLMTKHPGKR 583 + K R Sbjct: 266 ALYQLMLDCWQKDRNNR 282 >4XI2-A nrPDB Length = 446 Score = 234 bits (596), Expect = 1e-61, Method: Composition-based stats. Identities = 65/290 (22%), Positives = 129/290 (44%), Gaps = 18/290 (6%) Query: 300 ELRQKFERAKIGQGTKAPEEKTANTISKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLS 359 L + + Q AP S + D FL LG G FG V Sbjct: 155 GLISRLKYPVSKQNKNAPSTAGLGYGS--------WEIDPKDLTFLKELGTGQFGVVKYG 206 Query: 360 ERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFV 419 + +G + A+K++++ + +D+ +E E +V+ + L QL+ ++ + Sbjct: 207 KWRGQYD-VAIKMIREGSMSEDEFIE----EAKVM-MNLSHEKLVQLYGVCTKQRPIFII 260 Query: 420 MEYVNGGDLMYHIQQ-VGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEG 478 EY+ G L+ ++++ RF+ + ++ + +L+SK ++RDL N +++ +G Sbjct: 261 TEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQG 320 Query: 479 HIKIADFGMCKENIWDGVTTKTFCGTP-DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA- 536 +K++DFG+ + + D T+ P + PE++ Y + D WAFGVL++E+ + Sbjct: 321 VVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSL 380 Query: 537 GQAPFEGEDEDELFQSIMEH-NVAYPKSMSKEAVAICKGLMTKHPGKRLG 585 G+ P+E E + I + + P S+ I + +R Sbjct: 381 GKMPYERFTNSETAEHIAQGLRLYRPHLASERVYTIMYSCWHEKADERPS 430 >5SYS-A nrPDB Length = 286 Score = 234 bits (596), Expect = 1e-61, Method: Composition-based stats. Identities = 60/258 (23%), Positives = 112/258 (43%), Gaps = 12/258 (4%) Query: 333 NRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKR 392 + + + LG+G FG+ + GT A+K LK + E + E + Sbjct: 11 DAWEIPRESLRLEVKLGQGCFGECWMGTWNGTTR-VAIKTLKPGTMSP----EAFLQEAQ 65 Query: 393 VLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQV--GRFKEPHAVFYAAEI 450 V+ + L QL++ + + +Y V EY++ G L+ ++ + P V AA+I Sbjct: 66 VMKKL-RHEKLVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQI 123 Query: 451 AIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTP-DYIA 509 A G+ +++ ++RDL+ N+++ K+ADFG+ + + T + P + A Sbjct: 124 ASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTA 183 Query: 510 PEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIMEH-NVAYPKSMSKE 567 PE Y + D W+FG+LL E+ G+ P+ G E+ + + P + Sbjct: 184 PEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPES 243 Query: 568 AVAICKGLMTKHPGKRLG 585 + K P +R Sbjct: 244 LHDLMCQCWRKDPEERPT 261 >3KA0-A nrPDB Length = 320 Score = 233 bits (595), Expect = 1e-61, Method: Composition-based stats. Identities = 73/280 (26%), Positives = 117/280 (41%), Gaps = 32/280 (11%) Query: 339 LTDFNFL-MVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALP 397 + D+ VLG G GKV+ K T E +A+K+L D E + Sbjct: 14 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML--------QDCPKARREVELHWRA 65 Query: 398 GKPPFLTQLHSCFQT----MDRLYFVMEYVNGGDLMYHIQQVGR--FKEPHAVFYAAEIA 451 + P + ++ ++ L VME ++GG+L IQ G F E A I Sbjct: 66 SQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIG 125 Query: 452 IGLFFLQSKGIIYRDLKLDNVMLDS---EGHIKIADFGMCKENIWDGVTTKTFCGTPDYI 508 + +L S I +RD+K +N++ S +K+ DFG KE T C TP Y+ Sbjct: 126 EAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLT-EPCYTPYYV 184 Query: 509 APEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDEL----FQSIMEHNVAYP--- 561 APE++ + Y KS D W+ GV++Y +L G PF + I +P Sbjct: 185 APEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPE 244 Query: 562 -KSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFF 600 +S+E + + L+ P +R+ + H + Sbjct: 245 WSEVSEEVKMLIRNLLKTEPTQRMTIT-----EFMNHPWI 279 >6E2O-A nrPDB Length = 295 Score = 233 bits (595), Expect = 2e-61, Method: Composition-based stats. Identities = 84/286 (29%), Positives = 127/286 (44%), Gaps = 19/286 (6%) Query: 326 SKFDNNGNRDRMKLT-DFNFLM-----VLGKGSFGKVMLSERKGTDELYAVKILKKDVVI 379 S+ G+ + L D+ + VLGKG++G V A+K + + Sbjct: 2 SRSTEEGDCESDLLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPE---- 57 Query: 380 QDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQV-GRF 438 +D + E+ L K + Q F + ME V GG L ++ G Sbjct: 58 RDSRYSQPLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPL 117 Query: 439 K--EPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDS-EGHIKIADFGMCKENIWDG 495 K E FY +I GL +L I++RD+K DNV++++ G +KI+DFG K Sbjct: 118 KDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGIN 177 Query: 496 VTTKTFCGTPDYIAPEIIAYQP--YGKSVDWWAFGVLLYEMLAGQAPFE--GEDEDELFQ 551 T+TF GT Y+APEII P YGK+ D W+ G + EM G+ PF GE + +F+ Sbjct: 178 PCTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFK 237 Query: 552 -SIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKE 596 + + + P+SMS EA A P KR + + Sbjct: 238 VGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACANDLLVDEFLK 283 >3DKO-A nrPDB Length = 318 Score = 233 bits (595), Expect = 2e-61, Method: Composition-based stats. Identities = 63/316 (19%), Positives = 124/316 (39%), Gaps = 33/316 (10%) Query: 277 LLSQEEGEYFNVPVPPEGSEGNEELRQKFERAKIGQGTKAPEEKTANTISKFDNNGNRDR 336 + +E YF+ P + + E E + +F + Sbjct: 1 MQEGDEELYFHFKFPGTKTYIDPET----------------YEDPNRAVHQFAKELDASC 44 Query: 337 MKLTDFNFLMVLGKGSFGKVMLSERKGTDEL---YAVKILKKDVVIQDDDVECTMVEKRV 393 +K+ V+G G FG+V K + A+K LK V + + E + Sbjct: 45 IKIE-----RVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLK--VGYTEKQRRDFLCEASI 97 Query: 394 LALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQV-GRFKEPHAVFYAAEIAI 452 + P + L + V+E++ G L +++ G+F V IA Sbjct: 98 MGQFD-HPNVVHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGIAA 156 Query: 453 GLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCG---TPDYIA 509 G+ +L G ++RDL N++++S K++DFG+ + D T G + A Sbjct: 157 GMRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTA 216 Query: 510 PEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIMEH-NVAYPKSMSKE 567 PE I Y+ + + D W++G++++E+++ G+ P+ ++ ++I E + P Sbjct: 217 PEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPAPMDCPAG 276 Query: 568 AVAICKGLMTKHPGKR 583 + K +R Sbjct: 277 LHQLMLDCWQKERAER 292 >6E4F-A nrPDB Length = 290 Score = 233 bits (594), Expect = 2e-61, Method: Composition-based stats. Identities = 61/255 (23%), Positives = 123/255 (48%), Gaps = 10/255 (3%) Query: 335 DRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVL 394 + D FL LG G FG V + +G + A+K++K+ + +D+ +E E +V+ Sbjct: 26 WEIDPKDLTFLKELGTGQFGVVKYGKWRGQYD-VAIKMIKEGSMSEDEFIE----EAKVM 80 Query: 395 ALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQ-VGRFKEPHAVFYAAEIAIG 453 + L QL+ ++ + EY+ G L+ ++++ RF+ + ++ Sbjct: 81 -MNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEA 139 Query: 454 LFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTP-DYIAPEI 512 + +L+SK ++RDL N +++ +G +K++DFG+ + + D T+ P + PE+ Sbjct: 140 MEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEV 199 Query: 513 IAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIMEH-NVAYPKSMSKEAVA 570 + Y + D WAFGVL++E+ + G+ P+E E + I + + P S++ Sbjct: 200 LMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYT 259 Query: 571 ICKGLMTKHPGKRLG 585 I + +R Sbjct: 260 IMYSCWHEKADERPT 274 >3ZDU-A nrPDB Length = 325 Score = 233 bits (594), Expect = 2e-61, Method: Composition-based stats. Identities = 64/306 (20%), Positives = 111/306 (36%), Gaps = 40/306 (13%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 + L +G+GS+G VM + K T ++ A+KI + + + M E + L Sbjct: 5 YETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYER--PEQSVNKIAMREIKFLKQF-HHE 61 Query: 402 FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKG 461 L L F+ +++ V E+++ L + Y +I + +L S Sbjct: 62 NLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSNN 121 Query: 462 IIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPE-IIAYQPYGK 520 II+RD+K +N+++ G K+ DFG + G T Y APE ++ YGK Sbjct: 122 IIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYDDEVATRWYRAPELVLKDTSYGK 181 Query: 521 SVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSM---------------- 564 VD WA G ++ EM G + +L I+ + Sbjct: 182 PVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGVVLP 241 Query: 565 ----SKEAV-----------AICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLE 609 K A I + P R+ D+ H +F + + Sbjct: 242 QVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSS-----DLLHHEYFTRDGFIEKF 296 Query: 610 RKEIQP 615 E++ Sbjct: 297 MPELKA 302 >1BYG-A nrPDB Length = 278 Score = 233 bits (594), Expect = 2e-61, Method: Composition-based stats. Identities = 64/279 (22%), Positives = 114/279 (40%), Gaps = 18/279 (6%) Query: 327 KFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVEC 386 +F +G MK + L +GKG FG VML + +G AVK +K D + Sbjct: 10 EFYRSGWALNMK--ELKLLQTIGKGEFGDVMLGDYRGNK--VAVKCIKNDATA-----QA 60 Query: 387 TMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR--FKEPHAV 444 + E V+ + L + LY V EY+ G L+ +++ GR + Sbjct: 61 FLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLL 120 Query: 445 FYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGT 504 ++ ++ + +L+ ++RDL NV++ + K++DFG+ KE T K Sbjct: 121 KFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPV-- 178 Query: 505 PDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIMEH-NVAYPK 562 + APE + + + D W+FG+LL+E+ + G+ P+ ++ + + + P Sbjct: 179 -KWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPD 237 Query: 563 SMSKEAVAICKGLMTKHPGKRLGCGP--EGERDIKEHAF 599 + K R E IK H Sbjct: 238 GCPPAVYEVMKNCWHLDAAMRPSFLQLREQLEHIKTHEL 276 >1JPA-A nrPDB Length = 312 Score = 233 bits (594), Expect = 2e-61, Method: Composition-based stats. Identities = 57/270 (21%), Positives = 107/270 (39%), Gaps = 19/270 (7%) Query: 329 DNNGNRDRMKLTDF---NFLMVLGKGSFGKVMLSERKGTDE---LYAVKILKKDVVIQDD 382 N R+ K D V+G G FG+V K + A+K LK + Sbjct: 19 PNEAVREFAKEIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYT--EK 76 Query: 383 DVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQV-GRFKEP 441 + E ++ P + L + + E++ G L ++Q G+F Sbjct: 77 QRRDFLSEASIMGQFD-HPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVI 135 Query: 442 HAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWD--GVTTK 499 V IA G+ +L ++RDL N++++S K++DFG+ + D T Sbjct: 136 QLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYT 195 Query: 500 TFCG---TPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIME 555 + G + APE I Y+ + + D W++G++++E+++ G+ P+ ++ +I E Sbjct: 196 SALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAI-E 254 Query: 556 HNVAYPK--SMSKEAVAICKGLMTKHPGKR 583 + P + K R Sbjct: 255 QDYRLPPPMDCPSALHQLMLDCWQKDRNHR 284 >2OGV-A nrPDB Length = 317 Score = 232 bits (593), Expect = 3e-61, Method: Composition-based stats. Identities = 65/274 (23%), Positives = 116/274 (42%), Gaps = 22/274 (8%) Query: 332 GNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDEL-----YAVKILKKDVVIQDDDVEC 386 + + F LG G+FGKV+ + G + AVK+LK D+ E Sbjct: 30 NEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLK--STAHADEKEA 87 Query: 387 TMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQV----------G 436 M E ++++ G+ + L + + EY GDL+ +++ Sbjct: 88 LMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEADLDKEDGR 147 Query: 437 RFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGV 496 + + +++++A G+ FL SK I+RD+ NV+L + KI DFG+ ++ + D Sbjct: 148 PLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSN 207 Query: 497 T-TKTFCGTP-DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSI 553 K P ++APE I Y D W++G+LL+E+ + G P+ G + F + Sbjct: 208 YIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKL 267 Query: 554 MEHNVAY--PKSMSKEAVAICKGLMTKHPGKRLG 585 ++ P K +I + P R Sbjct: 268 VKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPT 301 >4Y93-A nrPDB Length = 446 Score = 232 bits (593), Expect = 3e-61, Method: Composition-based stats. Identities = 68/288 (23%), Positives = 132/288 (45%), Gaps = 16/288 (5%) Query: 302 RQKFERAKIGQGTKAPEEKTANTISKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSER 361 + + +G A TA + D FL LG G FG V + Sbjct: 156 CSQTAKNAMGCQILAAAPSTAGLGYGSW------EIDPKDLTFLKELGTGQFGVVKYGKW 209 Query: 362 KGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVME 421 +G + A+K++K+ + +D+ +E E +V+ + L QL+ ++ + E Sbjct: 210 RGQYD-VAIKMIKEGSMSEDEFIE----EAKVM-MNLSHEKLVQLYGVCTKQRPIFIITE 263 Query: 422 YVNGGDLMYHIQQ-VGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHI 480 Y+ G L+ ++++ RF+ + ++ + +L+SK ++RDL N +++ +G + Sbjct: 264 YMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVV 323 Query: 481 KIADFGMCKENIWDGVTTKTFCGTP-DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQ 538 K++DFGM + + D T+ T P + +PE++ Y + D WAFGVL++E+ + G+ Sbjct: 324 KVSDFGMTRYVLDDEYTSSTGSKFPVKWASPEVLMYSKFSSKSDIWAFGVLMWEIYSLGK 383 Query: 539 APFEGEDEDELFQSIMEH-NVAYPKSMSKEAVAICKGLMTKHPGKRLG 585 P+E E + I + + P S+ AI + +R Sbjct: 384 MPYERFTNSETAEHIAQGLRLPRPHLASERVYAIMYSCWHEKADERPT 431 >4XUF-A nrPDB Length = 297 Score = 232 bits (593), Expect = 3e-61, Method: Composition-based stats. Identities = 67/285 (23%), Positives = 121/285 (42%), Gaps = 35/285 (12%) Query: 334 RDRMKLTDFNFLMVLGKGSFGKVMLSE-----RKGTDELYAVKILKKDVVIQDDDVECTM 388 + + F VLG G+FGKVM + + G AVK+LK+ + E M Sbjct: 3 KWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKA--DSSEREALM 60 Query: 389 VEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQ-QVGRFKEPHAVF-- 445 E +++ G + L +Y + EY GDL+ +++ + +F E + Sbjct: 61 SELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYEN 120 Query: 446 --------------------YAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADF 485 +A ++A G+ FL+ K ++RDL NV++ +KI DF Sbjct: 121 QKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDF 180 Query: 486 GMCKENIWDG-VTTKTFCGTP-DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFE 542 G+ ++ + D + P ++APE + Y D W++G+LL+E+ + G P+ Sbjct: 181 GLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYP 240 Query: 543 GEDEDELFQSIMEH--NVAYPKSMSKEAVAICKGLMTKHPGKRLG 585 G D F ++++ + P ++E I + KR Sbjct: 241 GIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPS 285 >2J0K-A nrPDB Length = 656 Score = 232 bits (593), Expect = 3e-61, Method: Composition-based stats. Identities = 66/313 (21%), Positives = 123/313 (39%), Gaps = 18/313 (5%) Query: 280 QEEGEYFNVPVPPEGSEGNEELR--QKFERAKIGQGTKAPEEKTANTISKFDNNGNRDRM 337 Q+EGE +P + + +R EE T S D R+R+ Sbjct: 333 QKEGERALPSIPKLANNEKQGVRSHTVSVSETDDYAEIIDEEDTYTMPSTRDYEIQRERI 392 Query: 338 KLTDFNFLMVLGKGSFGKVMLSERKGTDEL---YAVKILKKDVVIQDDDVECTMVEKRVL 394 +G+G FG V + A+K K D E + E + Sbjct: 393 -----ELGRCIGEGQFGDVHQGIYMSPENPAMAVAIKTCKN--CTSDSVREKFLQEALTM 445 Query: 395 ALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQ-QVGRFKEPHAVFYAAEIAIG 453 P + +L T + ++ +ME G+L +Q + + YA +++ Sbjct: 446 RQFD-HPHIVKLIGVI-TENPVWIIMELCTLGELRSFLQVRKFSLDLASLILYAYQLSTA 503 Query: 454 LFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTP-DYIAPEI 512 L +L+SK ++RD+ NV++ + +K+ DFG+ + + P ++APE Sbjct: 504 LAYLESKRFVHRDIAARNVLVSATDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPES 563 Query: 513 IAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIMEHN-VAYPKSMSKEAVA 570 I ++ + + D W FGV ++E+L G PF+G +++ I + P + + Sbjct: 564 INFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYS 623 Query: 571 ICKGLMTKHPGKR 583 + P +R Sbjct: 624 LMTKCWAYDPSRR 636 >3DTC-A nrPDB Length = 271 Score = 232 bits (593), Expect = 3e-61, Method: Composition-based stats. Identities = 70/264 (26%), Positives = 113/264 (42%), Gaps = 20/264 (7%) Query: 336 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQ-DDDVECTMVEKRVL 394 + + ++G G FGKV + G AVK + D +E E ++ Sbjct: 3 EIDFAELTLEEIIGIGGFGKVYRAFWIGD--EVAVKAARHDPDEDISQTIENVRQEAKLF 60 Query: 395 ALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGL 454 A+ K P + L L VME+ GG L + R V +A +IA G+ Sbjct: 61 AML-KHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVL-SGKRIPPDILVNWAVQIARGM 118 Query: 455 FFLQSK---GIIYRDLKLDNVMLD--------SEGHIKIADFGMCKENIWDGVTTKTFCG 503 +L + II+RDLK N+++ S +KI DFG+ +E W T + G Sbjct: 119 NYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLARE--WHRTTKMSAAG 176 Query: 504 TPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVA--YP 561 ++APE+I + K D W++GVLL+E+L G+ PF G D + + + +A P Sbjct: 177 AYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIP 236 Query: 562 KSMSKEAVAICKGLMTKHPGKRLG 585 + + + + P R Sbjct: 237 STCPEPFAKLMEDCWNPDPHSRPS 260 >3SXS-A nrPDB Length = 268 Score = 232 bits (593), Expect = 3e-61, Method: Composition-based stats. Identities = 67/254 (26%), Positives = 119/254 (46%), Gaps = 10/254 (3%) Query: 336 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 395 +K + L LG G FG V L + KG + AVK++K+ + +D+ E + + Sbjct: 4 ELKREEITLLKELGSGQFGVVKLGKWKGQYD-VAVKMIKEGSMSEDE----FFQEAQTMM 58 Query: 396 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEP-HAVFYAAEIAIGL 454 P L + + +Y V EY++ G L+ +++ G+ EP + ++ G+ Sbjct: 59 KLS-HPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGM 117 Query: 455 FFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTP-DYIAPEII 513 FL+S I+RDL N ++D + +K++DFGM + + D + P + APE+ Sbjct: 118 AFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVF 177 Query: 514 AYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIME-HNVAYPKSMSKEAVAI 571 Y Y D WAFG+L++E+ + G+ P++ E+ + + H + P S I Sbjct: 178 HYFKYSSKSDVWAFGILMWEVFSLGKMPYDLYTNSEVVLKVSQGHRLYRPHLASDTIYQI 237 Query: 572 CKGLMTKHPGKRLG 585 + P KR Sbjct: 238 MYSCWHELPEKRPT 251 >5MJB-A nrPDB Length = 305 Score = 232 bits (592), Expect = 4e-61, Method: Composition-based stats. Identities = 57/270 (21%), Positives = 112/270 (41%), Gaps = 19/270 (7%) Query: 329 DNNGNRDRMKLTDFNFLM---VLGKGSFGKVMLSERKGTDE---LYAVKILKKDVVIQDD 382 N R+ K D +F+ V+G G FG+V K + A+K LK + Sbjct: 12 PNEAVREFAKEIDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAG--YSEK 69 Query: 383 DVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQV-GRFKEP 441 + E ++ + +L + + E++ L ++Q G+F Sbjct: 70 QRRDFLSEASIMGQFD-HRNIIRLEGVVTKSRPVMIITEFMENCALDSFLRQNDGQFTVI 128 Query: 442 HAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCK---ENIWDGVTT 498 V IA G+ +L ++RDL N++++S K++DFG+ + ++ D T Sbjct: 129 QLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYT 188 Query: 499 KTFCG--TPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIME 555 + G + APE IAY+ + + D W++G++++E+++ G+ P+ ++ +I E Sbjct: 189 SSLGGKIPVRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAI-E 247 Query: 556 HNVAYPK--SMSKEAVAICKGLMTKHPGKR 583 + P + K R Sbjct: 248 QDYRLPPPMDCPAALHQLMLDCWQKDRNSR 277 >5H2U-A nrPDB Length = 267 Score = 232 bits (592), Expect = 4e-61, Method: Composition-based stats. Identities = 54/251 (21%), Positives = 104/251 (41%), Gaps = 9/251 (3%) Query: 339 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 398 +F LG G FG+V K A+K++ +D ++ ++ E + + Sbjct: 5 REEFTLCRKLGSGYFGEVFEGLWK-DRVQVAIKVISRDNLLHQQMLQ---SEIQAMKKL- 59 Query: 399 KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQ--VGRFKEPHAVFYAAEIAIGLFF 456 + + L++ D +Y + E + G L+ ++ + A ++A G+ + Sbjct: 60 RHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCY 119 Query: 457 LQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQ 516 L+S+ I+RDL N+++ K+ DFG+ + D + + APE ++ Sbjct: 120 LESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEALSRG 179 Query: 517 PYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIMEH-NVAYPKSMSKEAVAICKG 574 Y D W+FG+LL+EM + GQ P+ G E F + + P + Sbjct: 180 HYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLT 239 Query: 575 LMTKHPGKRLG 585 + P +R Sbjct: 240 CWCRDPEQRPT 250 >3BEA-A nrPDB Length = 333 Score = 232 bits (591), Expect = 4e-61, Method: Composition-based stats. Identities = 66/278 (23%), Positives = 116/278 (41%), Gaps = 26/278 (9%) Query: 332 GNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDEL-----YAVKILKKDVVIQDDDVEC 386 + + F LG G+FGKV+ + G + AVK+LK D+ E Sbjct: 38 NEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLK--STAHADEKEA 95 Query: 387 TMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR--------- 437 M E ++++ G+ + L + + EY GDL+ +++ R Sbjct: 96 LMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKSRVLETDPAFA 155 Query: 438 -----FKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENI 492 + +++++A G+ FL SK I+RD+ NV+L + KI DFG+ ++ + Sbjct: 156 IANSTLSTRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIM 215 Query: 493 WDGVT-TKTFCGTP-DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDEL 549 D K P ++APE I Y D W++G+LL+E+ + G P+ G + Sbjct: 216 NDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSK 275 Query: 550 FQSIMEHNVAY--PKSMSKEAVAICKGLMTKHPGKRLG 585 F +++ P K +I + P R Sbjct: 276 FYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPT 313 >6DTL-A nrPDB Length = 364 Score = 232 bits (591), Expect = 4e-61, Method: Composition-based stats. Identities = 61/309 (19%), Positives = 123/309 (39%), Gaps = 46/309 (14%) Query: 345 LMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLT 404 +M +GKG++G V + T+E A+K + + D + T+ E ++L + Sbjct: 35 IMPIGKGAYGIVCSAMNSETNESVAIKKI-ANAFDNKIDAKRTLREIKLLRHMD-HENIV 92 Query: 405 QLHSCFQTM-----DRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQS 459 + + +Y E ++ DL I+ E H ++ +I GL ++ S Sbjct: 93 AIRDIIPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQILRGLKYIHS 151 Query: 460 KGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPE-IIAYQPY 518 +++RDLK N++L++ +KI DFG+ + + + T Y APE ++ Y Sbjct: 152 ANVLHRDLKPSNLLLNANCDLKICDFGLAR-VTSESDFMTEYVVTRWYRAPELLLNSSDY 210 Query: 519 GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIME----------------------H 556 ++D W+ G + E++ + F G D + +ME Sbjct: 211 TAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQ 270 Query: 557 NVAYP--------KSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKL 608 YP ++ A+ + + ++T P +R+ D H + + + Sbjct: 271 LPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVL-----DALAHPYLNSLH-DIS 324 Query: 609 ERKEIQPPY 617 + E P+ Sbjct: 325 DEPECTIPF 333 >4BGQ-A nrPDB Length = 304 Score = 232 bits (591), Expect = 5e-61, Method: Composition-based stats. Identities = 68/298 (22%), Positives = 125/298 (41%), Gaps = 42/298 (14%) Query: 339 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 398 + F L V+G+G++G V+ K T E+ A+K K D ++ E T+ E ++L Sbjct: 11 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFK-DSEENEEVKETTLRELKMLRTLK 69 Query: 399 KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAV-FYAAEIAIGLFFL 457 + + +L F+ +LY V EYV +++ ++++ P V Y ++ + + Sbjct: 70 Q-ENIVELKEAFRRRGKLYLVFEYVEK-NMLELLEEMPNGVPPEKVKSYIYQLIKAIHWC 127 Query: 458 QSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIW-DGVTTKTFCGTPDYIAPEIIAYQ 516 I++RD+K +N+++ +K+ DFG + + T Y +PE++ Sbjct: 128 HKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYDEEVATRWYRSPELLLGA 187 Query: 517 PYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIME-------------------HN 557 PYGKSVD W+ G +L E+ GQ F GE E + +I + H Sbjct: 188 PYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHG 247 Query: 558 VAYPK-------------SMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRY 602 + +P ++ + + K L+ P R H F+ Sbjct: 248 LRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRY-----LTEQCLNHPTFQT 300 >4QNY-A nrPDB Length = 354 Score = 232 bits (591), Expect = 5e-61, Method: Composition-based stats. Identities = 60/301 (19%), Positives = 118/301 (39%), Gaps = 43/301 (14%) Query: 340 TDFNFLMVLGKGSFGKVMLSER-KGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 398 + ++G GS+G V+ + K + L A+K + K++ + + + E ++LA Sbjct: 20 DRYLLERIIGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFEEVILAKRILREIKLLAHFN 79 Query: 399 KPPFLTQLHSCF----QTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGL 454 + + + D Y VM+ + DL ++ E H F+ + L Sbjct: 80 DDNIIGLRNILTPEDPENFDHFYIVMDIMET-DLKQVLRSGQELTEAHIQFFIYQALRAL 138 Query: 455 FFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPE-II 513 + S G+I+RD+ N+++++ +KI DFG+ KE G + Y APE ++ Sbjct: 139 HIIHSAGVIHRDITPANILVNTNCDLKICDFGLAKEENDQGEYMTDYVTMRWYRAPELVM 198 Query: 514 AYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSI-------------------- 553 + Y +D W G +L E+L + F+G+D I Sbjct: 199 EDKDYSAQIDVWGIGCILGELLGSRPLFQGKDRVNQLDKIVDVIGTPSEEDINSVGSSAA 258 Query: 554 ---MEHNVAYP--------KSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRY 602 ++ P + S EA+ + + ++ +P +R+ H F Sbjct: 259 QKYLKKKSHRPQADWRQRYPTASPEALDLLRHMLVFNPKRRITVL-----QAMRHPFLEQ 313 Query: 603 I 603 + Sbjct: 314 L 314 >4EBW-A nrPDB Length = 304 Score = 231 bits (590), Expect = 6e-61, Method: Composition-based stats. Identities = 58/265 (21%), Positives = 109/265 (41%), Gaps = 16/265 (6%) Query: 326 SKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTD---ELYAVKILKKDVVIQDD 382 S D R+R+ +G+G FG V + A+K K D Sbjct: 29 STRDYEIQRERI-----ELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKN--CTSDS 81 Query: 383 DVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQ-QVGRFKEP 441 E + E + P + +L T + ++ +ME G+L +Q + Sbjct: 82 VREKFLQEALTMRQFD-HPHIVKLIGVI-TENPVWIIMELCTLGELRSFLQVRKYSLDLA 139 Query: 442 HAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTF 501 + YA +++ L +L+SK ++RD+ NV++ S +K+ DFG+ + + Sbjct: 140 SLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASK 199 Query: 502 CGTP-DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIMEHN-V 558 P ++APE I ++ + + D W FGV ++E+L G PF+G +++ I + Sbjct: 200 GKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERL 259 Query: 559 AYPKSMSKEAVAICKGLMTKHPGKR 583 P + ++ P +R Sbjct: 260 PMPPNCPPTLYSLMTKCWAYDPSRR 284 >2R2P-A nrPDB Length = 295 Score = 231 bits (590), Expect = 6e-61, Method: Composition-based stats. Identities = 54/257 (21%), Positives = 108/257 (42%), Gaps = 12/257 (4%) Query: 336 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDE---LYAVKILKKDVVIQDDDVECTMVEKR 392 ++ + V+G G FG+V K + A+K LK V + + E Sbjct: 18 EIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLK--VGYTEKQRRDFLGEAS 75 Query: 393 VLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQV-GRFKEPHAVFYAAEIA 451 ++ P + L + V EY+ G L +++ G+F V I+ Sbjct: 76 IMGQFD-HPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGIS 134 Query: 452 IGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCG---TPDYI 508 G+ +L G ++RDL N++++S K++DFG+ + D T G + Sbjct: 135 AGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWT 194 Query: 509 APEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIMEH-NVAYPKSMSK 566 APE IA++ + + D W++G++++E+++ G+ P+ ++ +++ E + P Sbjct: 195 APEAIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPA 254 Query: 567 EAVAICKGLMTKHPGKR 583 + K R Sbjct: 255 ALYQLMLDCWQKERNSR 271 >5X02-A nrPDB Length = 347 Score = 231 bits (590), Expect = 6e-61, Method: Composition-based stats. Identities = 67/285 (23%), Positives = 121/285 (42%), Gaps = 35/285 (12%) Query: 334 RDRMKLTDFNFLMVLGKGSFGKVMLSE-----RKGTDELYAVKILKKDVVIQDDDVECTM 388 + + F VLG G+FGKVM + + G AVK+LK+ + E M Sbjct: 42 KWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKA--DSSEREALM 99 Query: 389 VEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQ-QVGRFKEPHAVF-- 445 E +++ G + L +Y + EY GDL+ +++ + +F E + Sbjct: 100 SELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYEN 159 Query: 446 --------------------YAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADF 485 +A ++A G+ FL+ K ++RDL NV++ +KI DF Sbjct: 160 QKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDF 219 Query: 486 GMCKENIWDG-VTTKTFCGTP-DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFE 542 G+ ++ + D + P ++APE + Y D W++G+LL+E+ + G P+ Sbjct: 220 GLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYP 279 Query: 543 GEDEDELFQSIMEH--NVAYPKSMSKEAVAICKGLMTKHPGKRLG 585 G D F ++++ + P ++E I + KR Sbjct: 280 GIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPS 324 >1V0B-A nrPDB Length = 288 Score = 231 bits (590), Expect = 7e-61, Method: Composition-based stats. Identities = 58/297 (19%), Positives = 125/297 (42%), Gaps = 40/297 (13%) Query: 339 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 398 + ++ L +G+G++G V ++ E +A+K ++ + +D+ + T + + + Sbjct: 1 MEKYHGLEKIGEGTYGVVYKAQN-NYGETFALKKIRLEK--EDEGIPSTTIREISILKEL 57 Query: 399 KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQV-GRFKEPHAVFYAAEIAIGLFFL 457 K + +L+ T RL V E+++ DL + G + A + ++ G+ + Sbjct: 58 KHSNIVKLYDVIHTKKRLVLVFEHLDQ-DLKKLLDVCEGGLESVTAKSFLLQLLNGIAYC 116 Query: 458 QSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAY-Q 516 + +++RDLK N++++ EG +KIADFG+ + T Y AP+++ + Sbjct: 117 HDRRVLHRDLKPQNLLINREGELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVLMGSK 176 Query: 517 PYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIME-----------HNVAYPKS-- 563 Y ++D W+ G + EM+ G F G E + I + PK Sbjct: 177 KYSTTIDIWSVGCIFAEMVNGAPLFPGVSEADQLMRIFRILGTPNSKNWPNVTELPKYDP 236 Query: 564 ----------------MSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYID 604 + + + + ++ P +R+ + EHA+F+ + Sbjct: 237 NFTVYEPLPWESFLKGLDESGIDLLSKMLKLDPNQRITA-----KQALEHAYFKENN 288 >1CM8-A nrPDB Length = 367 Score = 231 bits (589), Expect = 7e-61, Method: Composition-based stats. Identities = 72/329 (21%), Positives = 130/329 (39%), Gaps = 61/329 (18%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 + L +G G++G V + T A+K L + + E R+L + Sbjct: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKL-YRPFQSELFAKRAYRELRLLKHM-RHE 84 Query: 402 FLTQLHSCFQTMDRL------YFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 455 + L F + L Y VM ++ G DL + + + E F ++ GL Sbjct: 85 NVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGK-LMKHEKLGEDRIQFLVYQMLKGLR 142 Query: 456 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEII-A 514 ++ + GII+RDLK N+ ++ + +KI DFG+ ++ + + T Y APE+I Sbjct: 143 YIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE---MTGYVVTRWYRAPEVILN 199 Query: 515 YQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSM---------- 564 + Y ++VD W+ G ++ EM+ G+ F+G D + + IM+ P Sbjct: 200 WMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAK 259 Query: 565 ---------------------SKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYI 603 S AV + + ++ +R+ G + H +F Sbjct: 260 NYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAG-----EALAHPYF--- 311 Query: 604 DWEKLERKEIQPPYKPKARDKRDTSNFDK 632 E L E + P+ + D +FD Sbjct: 312 --ESLHDTEDE----PQVQKYDD--SFDD 332 >4AU8-A nrPDB Length = 296 Score = 231 bits (589), Expect = 8e-61, Method: Composition-based stats. Identities = 60/299 (20%), Positives = 118/299 (39%), Gaps = 40/299 (13%) Query: 337 MKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLAL 396 M + L +G+G++G V ++ + T E+ A+K ++ D D+ V + + + L Sbjct: 3 MGSQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLD--DDDEGVPSSALREICLLK 60 Query: 397 PGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQV-GRFKEPHAVFYAAEIAIGLF 455 K + +LH + +L V E+ + DL + G + ++ GL Sbjct: 61 ELKHKNIVRLHDVLHSDKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFLFQLLKGLG 119 Query: 456 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAY 515 F S+ +++RDLK N++++ G +K+ADFG+ + T Y P+++ Sbjct: 120 FCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFG 179 Query: 516 -QPYGKSVDWWAFGVLLYEML-AGQAPFEGEDEDELFQSIME-----------HNVAYPK 562 + Y S+D W+ G + E+ AG+ F G D D+ + I P Sbjct: 180 AKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPD 239 Query: 563 SMSKEAV------------------AICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYI 603 + + L+ +P +R+ + +H +F Sbjct: 240 YKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISA-----EEALQHPYFSDF 293 >3KRL-A nrPDB Length = 335 Score = 230 bits (587), Expect = 1e-60, Method: Composition-based stats. Identities = 65/280 (23%), Positives = 115/280 (41%), Gaps = 28/280 (10%) Query: 332 GNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDEL-----YAVKILKKDVVIQDDDVEC 386 + + F LG G+FGKV+ + G + AVK+LK D+ E Sbjct: 38 NEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLK--STAHADEKEA 95 Query: 387 TMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR--------- 437 M E ++++ G+ + L + + EY GDL+ +++ Sbjct: 96 LMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKRPPGLEYSYNP 155 Query: 438 -------FKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKE 490 + +++++A G+ FL SK I+RD+ NV+L + KI DFG+ ++ Sbjct: 156 SHNPEEQLSSRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARD 215 Query: 491 NIWDGVT-TKTFCGTP-DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDED 547 + D K P ++APE I Y D W++G+LL+E+ + G P+ G + Sbjct: 216 IMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVN 275 Query: 548 ELFQSIMEHNVAY--PKSMSKEAVAICKGLMTKHPGKRLG 585 F +++ P K +I + P R Sbjct: 276 SKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPT 315 >4IC8-A nrPDB Length = 442 Score = 230 bits (587), Expect = 1e-60, Method: Composition-based stats. Identities = 67/353 (18%), Positives = 133/353 (37%), Gaps = 51/353 (14%) Query: 340 TDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK 399 ++ + +G G++G V + R+ T + A+K + + + + T+ E ++L K Sbjct: 55 DEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVV-TNAKRTLRELKILKHF-K 112 Query: 400 PPFLTQLHSCFQTM------DRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIG 453 + + + +Y V++ + DL I H ++ ++ G Sbjct: 113 HDNIIAIKDILRPTVPYGEFKSVYVVLDLME-SDLHQIIHSSQPLTLEHVRYFLYQLLRG 171 Query: 454 LFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENI----WDGVTTKTFCGTPDYIA 509 L ++ S +I+RDLK N++++ +KI DFGM + + T Y A Sbjct: 172 LKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRA 231 Query: 510 PE-IIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIM-------------- 554 PE +++ Y +++D W+ G + EMLA + F G++ Q IM Sbjct: 232 PELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAV 291 Query: 555 --EHNVAYPKSMSK---------------EAVAICKGLMTKHPGKRLGCGPEGERDIKEH 597 E AY +S+ +A+++ ++ P R+ H Sbjct: 292 GAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAA-----ALRH 346 Query: 598 AFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEFTRQPVELTPTDKLFIM 650 F + + + PP+ + T KE +E + I Sbjct: 347 PFLAKYH-DPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFHARREGIR 398 >4ZSG-A nrPDB Length = 347 Score = 230 bits (586), Expect = 2e-60, Method: Composition-based stats. Identities = 66/356 (18%), Positives = 134/356 (37%), Gaps = 64/356 (17%) Query: 340 TDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK 399 ++ + +G G++G V + R+ T + A+K + + + + T+ E ++L K Sbjct: 7 DEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVV-TNAKRTLRELKILKHF-K 64 Query: 400 PPFLTQLHSCFQTM------DRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIG 453 + + + +Y V++ + DL I H ++ ++ G Sbjct: 65 HDNIIAIKDILRPTVPYGEFKSVYVVLDLME-SDLHQIIHSSQPLTLEHVRYFLYQLLRG 123 Query: 454 LFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENI----WDGVTTKTFCGTPDYIA 509 L ++ S +I+RDLK N++++ +KI DFGM + + T Y A Sbjct: 124 LKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRA 183 Query: 510 PE-IIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIM-------------- 554 PE +++ Y +++D W+ G + EMLA + F G++ Q IM Sbjct: 184 PELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAV 243 Query: 555 --EHNVAYPKSMSK---------------EAVAICKGLMTKHPGKRLGCGPEGERDIKEH 597 E AY +S+ +A+++ ++ P R+ H Sbjct: 244 GAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAA-----ALRH 298 Query: 598 AFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEFTRQPVELTPTDKLFIMNLD 653 F + + + PP FD F R+ + + + ++ Sbjct: 299 PFLAKYH-DPDDEPDCAPP-------------FDFAFDREALTRERIKEAIVAEIE 340 >1G3N-A nrPDB Length = 326 Score = 229 bits (584), Expect = 3e-60, Method: Composition-based stats. Identities = 64/300 (21%), Positives = 119/300 (39%), Gaps = 45/300 (15%) Query: 342 FNFLMVLGKGSFGKVMLSER-KGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG-- 398 + + +G+G++GKV + K A+K ++ ++ T+ E VL Sbjct: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQT-GEEGMPLSTIREVAVLRHLETF 71 Query: 399 KPPFLTQLHSCFQ-----TMDRLYFVMEYVNGGDLMYHIQQVGR--FKEPHAVFYAAEIA 451 + P + +L +L V E+V+ DL ++ +V ++ Sbjct: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQLL 130 Query: 452 IGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPE 511 GL FL S +++RDLK N+++ S G IK+ADFG+ + + + T Y APE Sbjct: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLAR-IYSFQMALTSVVVTLWYRAPE 189 Query: 512 IIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIME-----HNVAYPKSM-- 564 ++ Y VD W+ G + EM + F G + + I++ +P+ + Sbjct: 190 VLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVAL 249 Query: 565 ------SKEA--------------VAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYID 604 SK A + +T +P KR+ H +F+ ++ Sbjct: 250 PRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYS-----ALSHPYFQDLE 304 >6CQF-A nrPDB Length = 297 Score = 229 bits (584), Expect = 3e-60, Method: Composition-based stats. Identities = 63/268 (23%), Positives = 111/268 (41%), Gaps = 12/268 (4%) Query: 339 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 398 ++ L LG G++G+V + K + +L A+K++K + DDDV E +L Sbjct: 15 RDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVK---MEPDDDVSTLQKEILILKTC- 70 Query: 399 KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQ 458 + + H + + +L+ ME+ G L Q G E + E+ GL +L Sbjct: 71 RHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLH 130 Query: 459 SKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPE---IIAY 515 S+ I+RD+K N++++ G +++ADFG+ + F GTP ++APE + Sbjct: 131 SQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLAFIGTPYWMAPEVAAVALK 190 Query: 516 QPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPK-----SMSKEAVA 570 Y + D W+ G+ E+ Q P + + + P+ S Sbjct: 191 GGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHN 250 Query: 571 ICKGLMTKHPGKRLGCGPEGERDIKEHA 598 K +TK P KR + Sbjct: 251 FIKVTLTKSPKKRPSATKMLSHQLVSQP 278 >2VWV-A nrPDB Length = 302 Score = 229 bits (584), Expect = 3e-60, Method: Composition-based stats. Identities = 57/269 (21%), Positives = 114/269 (42%), Gaps = 17/269 (6%) Query: 329 DNNGNRDRMKLTDFNFLM---VLGKGSFGKVMLSERKGTDEL---YAVKILKKDVVIQDD 382 N R+ K D +++ V+G G FG+V K + A+K LK + Sbjct: 2 PNEAVREFAKEIDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYT--ER 59 Query: 383 DVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQ-QVGRFKEP 441 + E ++ + P + +L + + E++ G L ++ G+F Sbjct: 60 QRREFLSEASIMGQF-EHPNIIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVI 118 Query: 442 HAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCK---ENIWDGVTT 498 V IA G+ +L ++RDL N++++S K++DFG+ + EN D T Sbjct: 119 QLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTET 178 Query: 499 KTFCG--TPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIME 555 + G + APE IA++ + + D W++G++++E+++ G+ P+ ++ +I + Sbjct: 179 SSLGGKIPIRWTAPEAIAFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQ 238 Query: 556 H-NVAYPKSMSKEAVAICKGLMTKHPGKR 583 + P + K R Sbjct: 239 DYRLPPPPDCPTSLHQLMLDCWQKDRNAR 267 >4PDO-A nrPDB Length = 299 Score = 229 bits (584), Expect = 4e-60, Method: Composition-based stats. Identities = 56/275 (20%), Positives = 111/275 (40%), Gaps = 18/275 (6%) Query: 319 EKTANTISKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERK-GTDEL---YAVKILK 374 E + KF + + V+G G FG+V K + + A+K LK Sbjct: 18 EDPNQAVLKFTTEIHPSCVTRQ-----KVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLK 72 Query: 375 KDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQ 434 + + E ++ + +L + + EY+ G L +++ Sbjct: 73 AGYT--EKQRVDFLGEAGIMGQFSHHNII-RLEGVISKYKPMMIITEYMENGALDKFLRE 129 Query: 435 V-GRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIW 493 G F V IA G+ +L + ++RDL N++++S K++DFG+ + Sbjct: 130 KDGEFSVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLED 189 Query: 494 DGVTTKTFCG---TPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDEL 549 D T T G + APE I+Y+ + + D W+FG++++E++ G+ P+ E+ Sbjct: 190 DPEATYTTSGGKIPIRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEV 249 Query: 550 FQSIMEH-NVAYPKSMSKEAVAICKGLMTKHPGKR 583 ++I + + P + + +R Sbjct: 250 MKAINDGFRLPTPMDCPSAIYQLMMQCWQQERARR 284 >5Z33-A nrPDB Length = 425 Score = 229 bits (583), Expect = 4e-60, Method: Composition-based stats. Identities = 70/345 (20%), Positives = 131/345 (37%), Gaps = 59/345 (17%) Query: 333 NRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKR 392 N+D + + LG+G++G V + T E A+K + +V + + + E + Sbjct: 24 NQDFIVDERYTVTKELGQGAYGIVCAAVNNQTSEGVAIKKV-TNVFSKKILAKRALREIK 82 Query: 393 VLALPGKPPFLTQLHSC----FQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAA 448 +L +T L+ + Y E + DL I+ + H + Sbjct: 83 LLQHFRGHRNITCLYDMDIPRPDNFNETYLYEELMEC-DLAAIIRSGQPLTDAHFQSFIY 141 Query: 449 EIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGV----TTKTFCGT 504 +I GL ++ S +++RDLK N++++++ +KI DFG+ + D + T Sbjct: 142 QILCGLKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSVDPEENAGYMTEYVAT 201 Query: 505 PDYIAPEI-IAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIME-------- 555 Y APEI +++Q Y K++D W+ G +L E+L G+ F+G D + I+ Sbjct: 202 RWYRAPEIMLSFQSYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQILHILGTPNEE 261 Query: 556 --------------------HNVAYP---KSMSKEAVAICKGLMTKHPGKRLGCGPEGER 592 +P + + +A+ + ++ P R+ Sbjct: 262 TLSRIGSPRAQEYVRNLPFMAKKPFPTLFPNANPDALDLLDRMLAFDPSSRIS-----VE 316 Query: 593 DIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEFTRQ 637 EH + + P P T NFD E Sbjct: 317 QALEHPYL------HIWHDASDEPDCPT------TFNFDFEVVED 349 >3G0E-A nrPDB Length = 336 Score = 229 bits (583), Expect = 5e-60, Method: Composition-based stats. Identities = 68/281 (24%), Positives = 112/281 (39%), Gaps = 30/281 (10%) Query: 333 NRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDE-----LYAVKILKKDVVIQDDDVECT 387 ++ +F LG G+FGKV+ + G + AVK+LK + + E Sbjct: 39 HKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHL--TEREAL 96 Query: 388 MVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR---------- 437 M E +VL+ G + L + EY GDL+ +++ Sbjct: 97 MSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKTSPA 156 Query: 438 --------FKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCK 489 + ++ ++A G+ FL SK I+RDL N++L KI DFG+ + Sbjct: 157 IMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLAR 216 Query: 490 ENIWDG-VTTKTFCGTP-DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDE 546 + D K P ++APE I Y D W++G+ L+E+ + G +P+ G Sbjct: 217 DIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPV 276 Query: 547 DELFQSIMEHNVAY--PKSMSKEAVAICKGLMTKHPGKRLG 585 D F +++ P+ E I K P KR Sbjct: 277 DSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPT 317 >5X5O-A nrPDB Length = 310 Score = 228 bits (582), Expect = 5e-60, Method: Composition-based stats. Identities = 66/257 (25%), Positives = 115/257 (44%), Gaps = 21/257 (8%) Query: 336 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 395 ++K D F G GSFG V ++ D+ AVK L K E +L+ Sbjct: 11 QIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLK-----------IEKEAEILS 59 Query: 396 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR--FKEPHAVFYAAEIAIG 453 + + Q + V EY + G L +I H + +A ++A G Sbjct: 60 VLS-HRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKG 118 Query: 454 LFFLQSK---GIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAP 510 + +L + +I+RDLK NV++ ++G +KI DFG + + T + GT ++AP Sbjct: 119 MHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASR--FHNHTTHMSLVGTFPWMAP 176 Query: 511 EIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHN--VAYPKSMSKEA 568 E+I P ++ D +++GV+L+EML + PF+G + ++ ++E N + P S + Sbjct: 177 EVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSF 236 Query: 569 VAICKGLMTKHPGKRLG 585 + KR Sbjct: 237 AELLHQCWEADAKKRPS 253 >5AMN-A nrPDB Length = 299 Score = 228 bits (582), Expect = 6e-60, Method: Composition-based stats. Identities = 60/269 (22%), Positives = 115/269 (42%), Gaps = 22/269 (8%) Query: 334 RDRMKLTDFNFLMVLGKGSFGKVMLS-----ERKGTDELYAVKILKKDVVIQDDDVECTM 388 + + LG+G FGKV+ + + + AVK+LK++ ++ + Sbjct: 17 KWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENA--SPSELRDLL 74 Query: 389 VEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR----------F 438 E VL P + +L+ L ++EY G L +++ + Sbjct: 75 SEFNVLKQVN-HPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYPDERAL 133 Query: 439 KEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTT 498 + +A +I+ G+ +L +++RDL N+++ +KI+DFG+ ++ + Sbjct: 134 TMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYV 193 Query: 499 KTFCGTP--DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIME 555 K G ++A E + Y D W+FGVLL+E++ G P+ G + LF + Sbjct: 194 KRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKT 253 Query: 556 -HNVAYPKSMSKEAVAICKGLMTKHPGKR 583 H + P + S+E + + P KR Sbjct: 254 GHRMERPDNCSEEMYRLMLQCWKQEPDKR 282 >2F9G-A nrPDB Length = 353 Score = 228 bits (581), Expect = 6e-60, Method: Composition-based stats. Identities = 59/325 (18%), Positives = 122/325 (37%), Gaps = 57/325 (17%) Query: 340 TDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK 399 +DF +LG+G++G V + K T E+ A+K + + + T+ E ++L Sbjct: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI--EPFDKPLFALRTLREIKILKHFKH 68 Query: 400 PPFL----TQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 455 + Q F+ + +Y + E + ++ + + H ++ + + Sbjct: 69 ENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVK 126 Query: 456 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCK----------ENIWDGVTTKTFCGTP 505 L +I+RDLK N++++S +K+ DFG+ + E + T Sbjct: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 Query: 506 DYIAPEI-IAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSI----------- 553 Y APE+ + Y +++D W+ G +L E+ + F G D I Sbjct: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDN 246 Query: 554 ----------MEHNVAYP-----------KSMSKEAVAICKGLMTKHPGKRLGCGPEGER 592 E+ + P ++ + + + + ++ P KR+ + Sbjct: 247 DLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITA-----K 301 Query: 593 DIKEHAFFRYI-DWEKLERKEIQPP 616 + EH + + D E PP Sbjct: 302 EALEHPYLQTYHDPNDEPEGEPIPP 326 >5GRN-A nrPDB Length = 356 Score = 228 bits (581), Expect = 7e-60, Method: Composition-based stats. Identities = 66/289 (22%), Positives = 108/289 (37%), Gaps = 38/289 (13%) Query: 333 NRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDE-----LYAVKILKKDVVIQDDDVECT 387 +R VLG G+FGKV+ G AVK+LK + + + Sbjct: 39 SRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKP--TARSSEKQAL 96 Query: 388 MVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR---------- 437 M E +++ G + L +Y + EY GDL+ ++ + Sbjct: 97 MSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHKKKSM 156 Query: 438 ----------------FKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIK 481 + + ++A G+ FL SK ++RDL NV+L +K Sbjct: 157 LDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVK 216 Query: 482 IADFGMCKENIWDGVTTKTFCGTP--DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQ 538 I DFG+ ++ + D ++APE I Y D W++G+LL+E+ + G Sbjct: 217 ICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGG 276 Query: 539 APFEGEDEDEL-FQSIMEH-NVAYPKSMSKEAVAICKGLMTKHPGKRLG 585 P+ G D + I +A P + E I P KR Sbjct: 277 TPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPS 325 >5G6V-A nrPDB Length = 324 Score = 228 bits (581), Expect = 7e-60, Method: Composition-based stats. Identities = 65/294 (22%), Positives = 112/294 (38%), Gaps = 41/294 (13%) Query: 339 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 398 + + L LG+G++ V + K TD L A+K ++ + ++ CT + + L Sbjct: 1 METYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLE---HEEGAPCTAIREVSLLKDL 57 Query: 399 KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPH-AVFYAAEIAIGLFFL 457 K + LH T L V EY++ DL ++ G H + ++ GL + Sbjct: 58 KHANIVTLHDIIHTEKSLTLVFEYLDK-DLKQYLDDCGNIINMHNVKLFLFQLLRGLAYC 116 Query: 458 QSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQP 517 + +++RDLK N++++ G +K+ADFG+ + T T Y P+I+ Sbjct: 117 HRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYDNEVVTLWYRPPDILLGST 176 Query: 518 -YGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIME-------------------HN 557 Y +D W G + YEM G+ F G +E I Sbjct: 177 DYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKT 236 Query: 558 VAYPKS-----------MSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFF 600 YPK + + + L+ R+ D +H FF Sbjct: 237 YNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISA-----EDAMKHPFF 285 >4R7H-A nrPDB Length = 343 Score = 228 bits (581), Expect = 7e-60, Method: Composition-based stats. Identities = 65/287 (22%), Positives = 116/287 (40%), Gaps = 35/287 (12%) Query: 332 GNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDEL-----YAVKILKKDVVIQDDDVEC 386 + + F LG G+FGKV+ + G + AVK+LK D+ E Sbjct: 42 NEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLK--STAHADEKEA 99 Query: 387 TMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQV----------- 435 M E ++++ G+ + L + + EY GDL+ +++ Sbjct: 100 LMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCTYGDLLNFLRRKAEAMLGPSLSP 159 Query: 436 ------------GRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIA 483 + + +++++A G+ FL SK I+RD+ NV+L + KI Sbjct: 160 GQDPEGLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIG 219 Query: 484 DFGMCKENIWDGVT-TKTFCGTP-DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAP 540 DFG+ ++ + D K P ++APE I Y D W++G+LL+E+ + G P Sbjct: 220 DFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDSVYTVQSDVWSYGILLWEIFSLGLNP 279 Query: 541 FEGEDEDELFQSIMEHNVAY--PKSMSKEAVAICKGLMTKHPGKRLG 585 + G + F +++ P K +I + P R Sbjct: 280 YPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPT 326 >4EWQ-A nrPDB Length = 383 Score = 227 bits (580), Expect = 9e-60, Method: Composition-based stats. Identities = 73/335 (21%), Positives = 124/335 (37%), Gaps = 60/335 (17%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 + L +G G++G V + T AVK L + + T E R+L K Sbjct: 47 YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSR-PFQSIIHAKRTYRELRLLKHM-KHE 104 Query: 402 FLTQLHSCF------QTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 455 + L F + + +Y V + G DL I + + + H F +I GL Sbjct: 105 NVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNN-IVKCQKLTDDHVQFLIYQILRGLK 162 Query: 456 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEI-IA 514 ++ S II+RDLK N+ ++ + +KI DFG+ + + + T Y APEI + Sbjct: 163 YIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE---MTGYVATRWYRAPEIMLN 219 Query: 515 YQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIME----HNVAYPKSMSKE--- 567 + Y ++VD W+ G ++ E+L G+ F G D + + I+ K +S E Sbjct: 220 WMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESAR 279 Query: 568 ------------------------AVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYI 603 AV + + ++ KR+ HA+F Sbjct: 280 NYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA-----QALAHAYFA-- 332 Query: 604 DWEKLERKEIQPPYKPKARDKRDTSNFDKEFTRQP 638 + P D D S ++ Sbjct: 333 --------QYHDPDDEPVADPYDQSFESRDLLIDE 359 >6CCF-A nrPDB Length = 290 Score = 227 bits (580), Expect = 9e-60, Method: Composition-based stats. Identities = 78/293 (26%), Positives = 132/293 (45%), Gaps = 37/293 (12%) Query: 337 MKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDD------------- 383 M+L + +GKG++G V L+ + D YA+K+L K +++ Sbjct: 2 MQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAA 61 Query: 384 ----------VECTMVEKRVLALPGKPPFLTQLHSCFQT--MDRLYFVMEYVNGGDLMYH 431 +E E +L + +L D LY V + + G +M Sbjct: 62 QGGPAKQLLPLERVYQEIAILKKLDHV-NVVKLIEVLDDPAEDNLYLVFDLLRKGPVME- 119 Query: 432 IQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKEN 491 + F E A Y ++ +GL +L + I++RD+K N++L +GH+KIADFG+ + Sbjct: 120 VPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQF 179 Query: 492 IWDGVTTKTFCGTPDYIAPEIIAYQPY---GKSVDWWAFGVLLYEMLAGQAPFEGEDEDE 548 + + GTP ++APE I+ GK++D WA GV LY + G+ PF + Sbjct: 180 EGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILA 239 Query: 549 LFQSIMEHNVAYP--KSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAF 599 L + I V +P +S+E + ++ K+P R+G DIK H + Sbjct: 240 LHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIG-----VPDIKLHPW 287 >3HKO-A nrPDB Length = 345 Score = 227 bits (579), Expect = 1e-59, Method: Composition-based stats. Identities = 68/318 (21%), Positives = 129/318 (40%), Gaps = 60/318 (18%) Query: 341 DFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQ--DDDVECTMVEKRVLALPG 398 ++ +G+GS+G V ++ T + A+KI+ K+ + Q DVE E R++ Sbjct: 27 KYHLKGAIGQGSYGVVRVAIENQTRAIRAIKIMNKNKIRQINPKDVERIKTEVRLMKKL- 85 Query: 399 KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHI-------------------------- 432 P + +L+ ++ + VME +GG L+ + Sbjct: 86 HHPNIARLYEVYEDEQYICLVMELCHGGHLLDKLNVFIDDSTGKCAMDVVKTQICPCPEC 145 Query: 433 ------------QQVGRF--KEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSE- 477 ++ F +E +I L +L ++GI +RD+K +N + + Sbjct: 146 NEEAINGSIHGFRESLDFVQREKLISNIMRQIFSALHYLHNQGICHRDIKPENFLFSTNK 205 Query: 478 -GHIKIADFGMCKENIW----DGVTTKTFCGTPDYIAPEIIA--YQPYGKSVDWWAFGVL 530 IK+ DFG+ KE + T GTP ++APE++ + YG D W+ GVL Sbjct: 206 SFEIKLVDFGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEVLNTTNESYGPKCDAWSAGVL 265 Query: 531 LYEMLAGQAPFEGEDEDELFQSIMEHNVAY--PKS--MSKEAVAICKGLMTKHPGKRLGC 586 L+ +L G PF G ++ + ++ + + P +S A + L+ ++ +R Sbjct: 266 LHLLLMGAVPFPGVNDADTISQVLNKKLCFENPNYNVLSPLARDLLSNLLNRNVDERFDA 325 Query: 587 GPEGERDIKEHAFFRYID 604 +H + Sbjct: 326 MR-----ALQHPWISQFS 338 >4UYA-A nrPDB Length = 340 Score = 227 bits (579), Expect = 1e-59, Method: Composition-based stats. Identities = 63/268 (23%), Positives = 112/268 (41%), Gaps = 18/268 (6%) Query: 331 NGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVE 390 G+ + ++G G FG+V + + + AVK ++D ++ Sbjct: 17 QGSPVHVAFERLELKELIGAGGFGQVYRATWQ--GQEVAVKAARQDPEQDAAAAAESVRR 74 Query: 391 KRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEI 450 + L + P + +L L V+E+ GG L + R V +A +I Sbjct: 75 EARLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGALNRAL-AGRRIPPHVLVNWAVQI 133 Query: 451 AIGLFFLQSK---GIIYRDLKLDNVMLDS--------EGHIKIADFGMCKENIWDGVTTK 499 A G+ +L + I++RDLK N++L +KI DFG+ +E W T Sbjct: 134 ARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLARE--WHRTTKM 191 Query: 500 TFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIM--EHN 557 G ++APE+I + K D W++GVLL+E+L G+ P+ G D + + + Sbjct: 192 ATAGAYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLT 251 Query: 558 VAYPKSMSKEAVAICKGLMTKHPGKRLG 585 + P + + + K + P R Sbjct: 252 LPIPSTCPEPFAKLMKECWQQDPHIRPS 279 >3CJF-A nrPDB Length = 309 Score = 227 bits (578), Expect = 2e-59, Method: Composition-based stats. Identities = 69/294 (23%), Positives = 123/294 (41%), Gaps = 30/294 (10%) Query: 327 KFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSE-----RKGTDELYAVKILKKDVVIQD 381 + + ++ N LG+G+FG+V+ ++ + T AVK+LK+ + Sbjct: 14 RLPYDASKWEFPRDRLNLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSE 73 Query: 382 DDVECTMVEKRVLALPGKPPFLTQLHSCFQTMD-RLYFVMEYVNGGDLMYHIQQVGR--- 437 M E ++L G + L L ++E+ G+L +++ Sbjct: 74 H--RALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFV 131 Query: 438 ---------FKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMC 488 H + Y+ ++A G+ FL S+ I+RDL N++L + +KI DFG+ Sbjct: 132 PYKDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLA 191 Query: 489 KENIWD-GVTTKTFCGTP-DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGED 545 ++ D K P ++APE I + Y D W+FGVLL+E+ + G +P+ G Sbjct: 192 RDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVK 251 Query: 546 EDELF-QSIMEH-NVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEH 597 DE F + + E + P + E P +R ++ EH Sbjct: 252 IDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPT-----FSELVEH 300 >4XLV-A nrPDB Length = 328 Score = 227 bits (578), Expect = 2e-59, Method: Composition-based stats. Identities = 68/322 (21%), Positives = 129/322 (40%), Gaps = 28/322 (8%) Query: 314 TKAPEEKTANTISKFD-NNGNRDRMKLTDFNFLMVLGKGSFGKVML--SERKGTDE---L 367 + PE +A+ + + + L LG+GSFG V + E Sbjct: 12 SSNPEYLSASDVFPSSVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETR 71 Query: 368 YAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGD 427 AVK + + +++ + E V+ + +L VME + GD Sbjct: 72 VAVKTVNESASLRERI--EFLNEASVMKGFTCH-HVVRLLGVVSKGQPTLVVMELMAHGD 128 Query: 428 LMYHIQQVGRFKEP----------HAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSE 477 L +++ + E + AAEIA G+ +L +K ++RDL N M+ + Sbjct: 129 LKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHD 188 Query: 478 GHIKIADFGMCKENIWDGVTTKTFCGTP--DYIAPEIIAYQPYGKSVDWWAFGVLLYEML 535 +KI DFGM ++ K G ++APE + + S D W+FGV+L+E+ Sbjct: 189 FTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEIT 248 Query: 536 A-GQAPFEGEDEDELFQSIMEHNV-AYPKSMSKEAVAICKGLMTKHPGKR---LGCGPEG 590 + + P++G +++ + +M+ P + + + + +P R L Sbjct: 249 SLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPNMRPTFLEIVNLL 308 Query: 591 ERDIKEHAFFRYIDWEKLERKE 612 + D+ H F + + E + Sbjct: 309 KDDL--HPSFPEVSFFHSEENK 328 >3HMP-A nrPDB Length = 342 Score = 226 bits (576), Expect = 3e-59, Method: Composition-based stats. Identities = 67/325 (20%), Positives = 127/325 (39%), Gaps = 30/325 (9%) Query: 292 PEGSEGNEELRQKFERAKIGQGTKAPEEKTANTISKFDNNGNRDRMKLTDFNFLMVLGKG 351 P GS E KFER Q +P+ T + + +K ++ L +G G Sbjct: 12 PRGSGMKETAAAKFER----QHMDSPDLGTDDDDKASSSANECISVKGRIYSILKQIGSG 67 Query: 352 SFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKP-PFLTQLHSCF 410 KV ++YA+K + + + ++ E L + + +L+ Sbjct: 68 GSSKVFQVLN-EKKQIYAIKYVNLEE-ADNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYE 125 Query: 411 QTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLD 470 T +Y VME DL +++ Y + + + GI++ DLK Sbjct: 126 ITDQYIYMVME-CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPA 184 Query: 471 NVMLDSEGHIKIADFGMCKENIWD--GVTTKTFCGTPDYIAPEIIAYQPYGKS------- 521 N ++ +G +K+ DFG+ + D V + GT +Y+ PE I + Sbjct: 185 NFLIV-DGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSK 243 Query: 522 ----VDWWAFGVLLYEMLAGQAPFEG-EDEDELFQSIME--HNVAYPKSMSKEAVAICKG 574 D W+ G +LY M G+ PF+ ++ +I++ H + +P K+ + K Sbjct: 244 ISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKC 303 Query: 575 LMTKHPGKRLGCGPEGERDIKEHAF 599 + + P +R+ ++ H + Sbjct: 304 CLKRDPKQRISI-----PELLAHPY 323 >5L6P-A nrPDB Length = 298 Score = 225 bits (573), Expect = 6e-59, Method: Composition-based stats. Identities = 55/270 (20%), Positives = 109/270 (40%), Gaps = 19/270 (7%) Query: 329 DNNGNRDRMKLTDF---NFLMVLGKGSFGKVMLSERKGTDE---LYAVKILKKDVVIQDD 382 N R+ K D V+G G FG+V K A+K LK V + Sbjct: 5 PNEAVREFAKEIDVSCVKIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLK--VGYTER 62 Query: 383 DVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQ-QVGRFKEP 441 + E ++ P + +L + + E++ L ++ G+F Sbjct: 63 QRRDFLSEASIMGQFD-HPNIIRLEGVVTKSRPVMILTEFMENCALDSFLRLNDGQFTVI 121 Query: 442 HAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCK---ENIWDGVTT 498 V IA G+ +L ++RDL N++++S K++DFG+ + ++ D T Sbjct: 122 QLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYT 181 Query: 499 KTFCG--TPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIME 555 + G + APE IAY+ + + D W++G++++E+++ G+ P+ ++ ++ E Sbjct: 182 SSLGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAV-E 240 Query: 556 HNVAYPK--SMSKEAVAICKGLMTKHPGKR 583 + P + + R Sbjct: 241 QDYRLPPPMDCPTALHQLMLDCWVRDRNLR 270 >1LUF-A nrPDB Length = 343 Score = 224 bits (572), Expect = 8e-59, Method: Composition-based stats. Identities = 59/302 (19%), Positives = 113/302 (37%), Gaps = 36/302 (11%) Query: 317 PEEKTANTISKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGT-----DELYAVK 371 P + + ++ +G+G+FG+V + G + AVK Sbjct: 24 PNPMYQRMPLLLNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVK 83 Query: 372 ILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYH 431 +LK++ D E ++A P + +L + + EY+ GDL Sbjct: 84 MLKEEASA--DMQADFQREAALMAEFDN-PNIVKLLGVCAVGKPMCLLFEYMAYGDLNEF 140 Query: 432 IQQV------------------------GRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDL 467 ++ + + A ++A G+ +L + ++RDL Sbjct: 141 LRSMSPHTVCSLSHSDLSTRARVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDL 200 Query: 468 KLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTF--CGTPDYIAPEIIAYQPYGKSVDWW 525 N ++ +KIADFG+ + ++ PE I Y Y D W Sbjct: 201 ATRNCLVGENMVVKIADFGLSRNIYSADYYKADGNDAIPIRWMPPESIFYNRYTTESDVW 260 Query: 526 AFGVLLYEMLA-GQAPFEGEDEDELFQSIMEHN-VAYPKSMSKEAVAICKGLMTKHPGKR 583 A+GV+L+E+ + G P+ G +E+ + + N +A P++ E + + +K P R Sbjct: 261 AYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILACPENCPLELYNLMRLCWSKLPADR 320 Query: 584 LG 585 Sbjct: 321 PS 322 >3OHT-A nrPDB Length = 389 Score = 224 bits (572), Expect = 8e-59, Method: Composition-based stats. Identities = 71/320 (22%), Positives = 121/320 (37%), Gaps = 55/320 (17%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 + L +G G++G V S + AVK L + + T E R+L K Sbjct: 53 YQTLSPVGSGAYGSVCSSYDVKSGLKIAVKKLSR-PFQSIIHAKRTYRELRLLKHM-KHE 110 Query: 402 FLTQLHSCF------QTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 455 + L F + + +Y V + G DL I + + + H F +I GL Sbjct: 111 NVIGLLDVFTPATSLEEFNDVYLVTHLM-GADLNN-IVKCQKLTDDHVQFLIYQILRGLK 168 Query: 456 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEI-IA 514 ++ S II+RDLK N+ ++ + +KI DFG+ + + + T Y APEI + Sbjct: 169 YIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE---MTGYVATRWYRAPEIMLN 225 Query: 515 YQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSM---------- 564 + Y +VD W+ G ++ E+L G+ F G D Q IM P S+ Sbjct: 226 WMHYNMTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPASVISRMPSHEAR 285 Query: 565 ---------------------SKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYI 603 + AV + + ++ KR+ + H +F Sbjct: 286 NYINSLPQMPKRNFADVFIGANPLAVDLLEKMLVLDTDKRITAS-----EALAHPYFSQY 340 Query: 604 DWEKLERKEIQPPYKPKARD 623 + +P +P + Sbjct: 341 -----HDPDDEPESEPYDQS 355 >2BRG-A nrPDB Length = 297 Score = 224 bits (571), Expect = 9e-59, Method: Composition-based stats. Identities = 65/270 (24%), Positives = 132/270 (48%), Gaps = 14/270 (5%) Query: 339 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 398 + D++ + LG+G++G+V L+ + T+E AVKI+ + D + ++ + Sbjct: 6 VEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAV---DCPENIKKEICINKML 62 Query: 399 KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQ 458 + + + + + Y +EY +GG+L I+ EP A + ++ G+ +L Sbjct: 63 NHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLH 122 Query: 459 SKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTT--KTFCGTPDYIAPEIIAYQ 516 GI +RD+K +N++LD ++KI+DFG+ ++ CGT Y+APE++ + Sbjct: 123 GIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRR 182 Query: 517 PY-GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAY---PKSMSKEAVAIC 572 + + VD W+ G++L MLAG+ P++ + S + Y K + +A+ Sbjct: 183 EFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALL 242 Query: 573 KGLMTKHPGKRLGCGPEGERDIKEHAFFRY 602 ++ ++P R+ DIK+ ++ Sbjct: 243 HKILVENPSARITI-----PDIKKDRWYNK 267 >5FM2-A nrPDB Length = 355 Score = 224 bits (571), Expect = 1e-58, Method: Composition-based stats. Identities = 65/319 (20%), Positives = 123/319 (38%), Gaps = 40/319 (12%) Query: 302 RQKFERAKIGQGTKAPEEKTANTISKFD----NNGNRDRMKLTDFNFLMVLGKGSFGKVM 357 Q F + G + P + D + + LG+G FGKV+ Sbjct: 22 AQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVV 81 Query: 358 LS-----ERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQT 412 + + + AVK+LK++ ++ + E VL P + +L+ Sbjct: 82 KATAFHLKGRAGYTTVAVKMLKENA--SPSELRDLLSEFNVLKQVN-HPHVIKLYGACSQ 138 Query: 413 MDRLYFVMEYVNGGDLMYHIQQVGR------------------------FKEPHAVFYAA 448 L ++EY G L +++ + + +A Sbjct: 139 DGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAW 198 Query: 449 EIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTP--D 506 +I+ G+ +L +++RDL N+++ +KI+DFG+ ++ + K G Sbjct: 199 QISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVK 258 Query: 507 YIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIME-HNVAYPKSM 564 ++A E + Y D W+FGVLL+E++ G P+ G + LF + H + P + Sbjct: 259 WMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNC 318 Query: 565 SKEAVAICKGLMTKHPGKR 583 S+E + + P KR Sbjct: 319 SEEMYRLMLQCWKQEPDKR 337 >5KKR-C nrPDB Length = 395 Score = 224 bits (571), Expect = 1e-58, Method: Composition-based stats. Identities = 77/375 (20%), Positives = 143/375 (38%), Gaps = 64/375 (17%) Query: 289 PVP------PEGSEGNEELRQKFERAKIGQGTKAPE--EKTANTISKFDNNGNR-DRMKL 339 P P P+GS N + + + + E E+ + F + +K Sbjct: 8 PTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELKD 67 Query: 340 TDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK 399 DF + LG G+ G V K + + A K++ ++ + ++ + + Sbjct: 68 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEI---KPAIRNQIIRELQVLHECN 124 Query: 400 PPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFL-Q 458 P++ + F + + ME+++GG L +++ GR E + + GL +L + Sbjct: 125 SPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLRE 184 Query: 459 SKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY 518 I++RD+K N++++S G IK+ DFG+ + I +F GT Y++PE + Y Sbjct: 185 KHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS--MANSFVGTRSYMSPERLQGTHY 242 Query: 519 GKSVDWWAFGVLLYEMLAGQAPFEGEDED------------------------------- 547 D W+ G+ L EM G+ P D Sbjct: 243 SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY 302 Query: 548 -----------ELFQSIM-EHNVAYPKSM-SKEAVAICKGLMTKHPGKRLGCGPEGERDI 594 EL I+ E P ++ S E + K+P +R + + Sbjct: 303 GMDSRPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFVNKCLIKNPAERA-----DLKQL 357 Query: 595 KEHAFFRYIDWEKLE 609 HAF + D E+++ Sbjct: 358 MVHAFIKRSDAEEVD 372 >1UA2-A nrPDB Length = 346 Score = 224 bits (570), Expect = 1e-58, Method: Composition-based stats. Identities = 65/276 (23%), Positives = 107/276 (38%), Gaps = 32/276 (11%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQ-DDDVECTMVEKRVLALPGKP 400 + L LG+G F V + K T+++ A+K +K + D + T + + L Sbjct: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 Query: 401 PFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR-FKEPHAVFYAAEIAIGLFFLQS 459 P + L F + V +++ DL I+ H Y GL +L Sbjct: 72 PNIIGLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQ 130 Query: 460 KGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAY-QPY 518 I++RDLK +N++LD G +K+ADFG+ K T Y APE++ + Y Sbjct: 131 HWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMY 190 Query: 519 GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIME-----HNVAYPKSMS-------- 565 G VD WA G +L E+L G+ + + I E +P S Sbjct: 191 GVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFK 250 Query: 566 ---------------KEAVAICKGLMTKHPGKRLGC 586 + + + +GL +P R+ Sbjct: 251 SFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITA 286 >2ZMD-A nrPDB Length = 390 Score = 224 bits (570), Expect = 1e-58, Method: Composition-based stats. Identities = 66/325 (20%), Positives = 126/325 (38%), Gaps = 30/325 (9%) Query: 292 PEGSEGNEELRQKFERAKIGQGTKAPEEKTANTISKFDNNGNRDRMKLTDFNFLMVLGKG 351 P GS E KFER Q +P+ T + + +K ++ L +G G Sbjct: 12 PRGSGMKETAAAKFER----QHMDSPDLGTDDDDKASSSANECISVKGRIYSILKQIGSG 67 Query: 352 SFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKP-PFLTQLHSCF 410 KV ++YA+K + + + ++ E L + + +L+ Sbjct: 68 GSSKVFQVLN-EKKQIYAIKYVNLEE-ADNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYE 125 Query: 411 QTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLD 470 T +Y VME DL +++ Y + + + GI++ DLK Sbjct: 126 ITDQYIYMVME-CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPA 184 Query: 471 NVMLDSEGHIKIADFGMCKENIWD--GVTTKTFCGTPDYIAPEIIAYQPYGKS------- 521 N ++ +G +K+ DFG+ + D V + G +Y+ PE I + Sbjct: 185 NFLIV-DGMLKLIDFGIANQMQPDTTSVVKDSQVGAVNYMPPEAIKDMSSSRENGKSKSK 243 Query: 522 ----VDWWAFGVLLYEMLAGQAPFEG-EDEDELFQSIME--HNVAYPKSMSKEAVAICKG 574 D W+ G +LY M G+ PF+ ++ +I++ H + +P K+ + K Sbjct: 244 ISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKC 303 Query: 575 LMTKHPGKRLGCGPEGERDIKEHAF 599 + + P +R+ ++ H + Sbjct: 304 CLKRDPKQRISI-----PELLAHPY 323 >5VO2-A nrPDB Length = 300 Score = 223 bits (568), Expect = 2e-58, Method: Composition-based stats. Identities = 65/269 (24%), Positives = 114/269 (42%), Gaps = 21/269 (7%) Query: 331 NGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVE 390 + + + + L +G G+ G V L E AVK ++ +++ D++ Sbjct: 3 SEDLWEVPFEEILDLQWVGSGAQGAVFLGRFH--GEEVAVKKVRD---LKETDIKHLR-- 55 Query: 391 KRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEI 450 K P + +ME+ G L ++ V ++ I Sbjct: 56 ------KLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGI 109 Query: 451 AIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAP 510 A G+ +L II+RDLK N+++ + +KI+DFG KE D T +F GT ++AP Sbjct: 110 AGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKEL-SDKSTKMSFAGTVAWMAP 168 Query: 511 EIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAY--PKSMSKEA 568 E+I +P + VD W+FGV+L+E+L G+ P++ D + + +++ P S Sbjct: 169 EVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGF 228 Query: 569 VAICKGLMTKHPGKRLGCGPEGERDIKEH 597 + + P R R I H Sbjct: 229 KILLRQCWNSKPRNRPS-----FRQILLH 252 >3MIA-A nrPDB Length = 351 Score = 222 bits (567), Expect = 3e-58, Method: Composition-based stats. Identities = 58/324 (17%), Positives = 120/324 (37%), Gaps = 41/324 (12%) Query: 338 KLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALP 397 +++ + L +G+G+FG+V + + T + A+K + + + + + E ++L L Sbjct: 15 EVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPI-TALREIKILQLL 73 Query: 398 GKPPFLTQLHSCFQT-------MDRLYFVMEYVNGGDLMYHIQQV-GRFKEPHAVFYAAE 449 + + C +Y V ++ DL + V +F Sbjct: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLVKFTLSEIKRVMQM 132 Query: 450 IAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKEN----IWDGVTTKTFCGTP 505 + GL+++ I++RD+K NV++ +G +K+ADFG+ + T Sbjct: 133 LLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTL 192 Query: 506 DYIAPEIIAY-QPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSM 564 Y PE++ + YG +D W G ++ EM +G E Sbjct: 193 WYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQL-------------- 238 Query: 565 SKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDK 624 A+ L PE ++ + + ++ K ++++++ K RD Sbjct: 239 -----ALISQLCG-------SITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDP 286 Query: 625 RDTSNFDKEFTRQPVELTPTDKLF 648 DK P + +D Sbjct: 287 YALDLIDKLLVLDPAQRIDSDDAL 310 >4HZS-A nrPDB Length = 341 Score = 222 bits (567), Expect = 3e-58, Method: Composition-based stats. Identities = 65/259 (25%), Positives = 111/259 (42%), Gaps = 12/259 (4%) Query: 337 MKLTDFNFLMVLGKGSFGKVMLSERKG-TDELY--AVKILKKDVVIQDDDVECTMVEKRV 393 + D L LG GSFG V E + + AVK LK DV+ Q + ++ + E Sbjct: 9 IGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNA 68 Query: 394 LALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQV-GRFKEPHAVFYAAEIAI 452 + L +L+ T + V E G L+ +++ G F YA ++A Sbjct: 69 M-HSLDHRNLIRLYGVVLT-PPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAE 126 Query: 453 GLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTT---KTFCGTPDYIA 509 G+ +L+SK I+RDL N++L + +KI DFG+ + + + + A Sbjct: 127 GMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCA 186 Query: 510 PEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIME--HNVAYPKSMSK 566 PE + + + + D W FGV L+EM GQ P+ G + ++ I + + P+ + Sbjct: 187 PESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQ 246 Query: 567 EAVAICKGLMTKHPGKRLG 585 + + P R Sbjct: 247 DIYNVMVQCWAHKPEDRPT 265 >3ZBF-A nrPDB Length = 322 Score = 222 bits (566), Expect = 4e-58, Method: Composition-based stats. Identities = 59/269 (21%), Positives = 111/269 (41%), Gaps = 25/269 (9%) Query: 339 LTDFNFLMVLGKGSFGKVMLSERK-----GTDEL-YAVKILKKDVVIQDDDVECTMVEKR 392 ++LG G+FG+V G+ E+ AVK LKK D + + E Sbjct: 32 REKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGST--DQEKIEFLKEAH 89 Query: 393 VLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFK-------EPHAVF 445 +++ P L QL C + Y ++E + GGDL+ ++++ V Sbjct: 90 LMSKFNHPNILKQLGVCLLNEPQ-YIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVD 148 Query: 446 YAAEIAIGLFFLQSKGIIYRDLKLDNVML-----DSEGHIKIADFGMCKENIWDGVTTKT 500 +I+ G +L+ I+RDL N ++ S +KI DFG+ ++ + K Sbjct: 149 LCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKR 208 Query: 501 FCGTP--DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIME-H 556 G ++APE + + D W+FG+L++E+L G P+ ++ + Sbjct: 209 GEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGG 268 Query: 557 NVAYPKSMSKEAVAICKGLMTKHPGKRLG 585 + P++ + + + P +R Sbjct: 269 RLEPPRNCPDDLWNLMTQCWAQEPDQRPT 297 >3GC0-A nrPDB Length = 329 Score = 222 bits (566), Expect = 4e-58, Method: Composition-based stats. Identities = 62/304 (20%), Positives = 118/304 (38%), Gaps = 44/304 (14%) Query: 339 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 398 + + + LG+G++G+V + T+E A+K ++ + +++ V T + + L Sbjct: 33 IDRYRRITKLGEGTYGEVYKAIDTVTNETVAIKRIRLEH--EEEGVPGTAIREVSLLKEL 90 Query: 399 KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQ 458 + + +L S RL+ + EY DL ++ + + ++ G+ F Sbjct: 91 QHRNIIELKSVIHHNHRLHLIFEYAEN-DLKKYMDKNPDVSMRVIKSFLYQLINGVNFCH 149 Query: 459 SKGIIYRDLKLDNVML-----DSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEII 513 S+ ++RDLK N++L +KI DFG+ + T Y PEI+ Sbjct: 150 SRRCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQFTHEIITLWYRPPEIL 209 Query: 514 AY-QPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEH---------------- 556 + Y SVD W+ + EML F G+ E + I E Sbjct: 210 LGSRHYSTSVDIWSIACIWAEMLMKTPLFPGDSEIDQLFKIFEVLGLPDDTTWPGVTALP 269 Query: 557 --NVAYPKSMSKEAVAIC------------KGLMTKHPGKRLGCGPEGERDIKEHAFFRY 602 ++PK K + ++ P KR+ ++ EH +F + Sbjct: 270 DWKQSFPKFRGKTLKRVLGALLDDEGLDLLTAMLEMDPVKRISA-----KNALEHPYFSH 324 Query: 603 IDWE 606 D++ Sbjct: 325 NDFD 328 >5DBX-A nrPDB Length = 328 Score = 222 bits (566), Expect = 4e-58, Method: Composition-based stats. Identities = 66/285 (23%), Positives = 118/285 (41%), Gaps = 32/285 (11%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 + V+G G+ V + K E A+K + + D + E + ++ P Sbjct: 13 YELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMD--ELLKEIQAMSQCS-HP 69 Query: 402 FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHI--------QQVGRFKEPHAVFYAAEIAIG 453 + ++ F D L+ VM+ ++GG ++ I + G +E E+ G Sbjct: 70 NVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEG 129 Query: 454 LFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTT-----KTFCGTPDYI 508 L +L G I+RDLK N++L +G ++IADFG+ G T K F GTP ++ Sbjct: 130 LDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKDFVGTPCWM 189 Query: 509 APEIIAY-QPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNV--------- 558 APE++ + Y D W+FG+ E+ G AP+ ++ ++++ Sbjct: 190 APEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLETGVED 249 Query: 559 -AYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRY 602 K K + + K P KR ++ + FF+ Sbjct: 250 KEMMKKYGKSFRKLLSLCLQKDPSKRPTAA-----ELLKCKFFQK 289 >4O2Z-A nrPDB Length = 377 Score = 222 bits (566), Expect = 4e-58, Method: Composition-based stats. Identities = 60/335 (17%), Positives = 124/335 (37%), Gaps = 45/335 (13%) Query: 319 EKTANTISKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVV 378 K ++ +G+ + + + L +LG G++G T E ++K + DV Sbjct: 25 PKIVGDFKVYNVSGSPFEV-PSKYTLLKILGMGAYGIACSCLDGDTGEKVSIKKCR-DVF 82 Query: 379 IQDDDVECTMVEKRVLALPGKPP--FLTQ----LHSCFQTMDRLYFVMEYVNGGDLMYHI 432 +D + + E ++ + L + + + +Y V ++ D+ + Sbjct: 83 RDVEDGKRVLREIDMMRFFHHENLLNVVNILPPLKREYHSFEDVYVVTPLMD-VDMNVVL 141 Query: 433 QQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENI 492 + +E H ++ +I GL +L S + +RDLK N++ + +KI DFG+ + Sbjct: 142 RSRQVLEESHMQYFVYQILRGLKYLHSANVAHRDLKPANLVTNISCELKIIDFGLSRSVD 201 Query: 493 WDGVTTKTFCGTPDYIAPEIIAYQP-YGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQ 551 + T Y PE++ Y +VD W+ G + EM + F G + + + Sbjct: 202 VPYSELTDYVITRWYRPPELLLENTNYSTAVDIWSVGCIFAEMYNRKPVFPGRNTMDQLR 261 Query: 552 SIMEHNVAYPKSMSK-----------------------------EAVAICKGLMTKHPGK 582 I +H P S+ + E + + T P K Sbjct: 262 MIAQHIGKPPASIVEHREALEKLNELPDGSLNIPKLVPGLAGNTEGIDFLSKMWTLDPSK 321 Query: 583 RLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPY 617 R D+ H + ++ ++ + P+ Sbjct: 322 RPTAA-----DMLAHPYLAHLH-DEEDEPTCPCPF 350 >3VN9-A nrPDB Length = 340 Score = 222 bits (565), Expect = 5e-58, Method: Composition-based stats. Identities = 67/320 (20%), Positives = 127/320 (39%), Gaps = 22/320 (6%) Query: 293 EGSEGNEELRQKFERAKIGQGTKAPEEKTANTISKFDNNGNRDRMKLTDFNFLMVLGKGS 352 +G + N L + + A T + + ++ + +K D +M LG+G+ Sbjct: 5 KGKKRNPGL-KIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGA 63 Query: 353 FGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQT 412 +G V + ++ AVK ++ + + + +++ + PF + Sbjct: 64 YGVVEKMRHVPSGQIMAVKRIR--ATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFR 121 Query: 413 MDRLYFVMEYVNGGDLMYH----IQQVGRFKEPHAVFYAAEIAIGLFFLQSK-GIIYRDL 467 ++ ME ++ L I + E A I L L SK +I+RD+ Sbjct: 122 EGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDV 180 Query: 468 KLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEII----AYQPYGKSVD 523 K NV++++ G +K+ DFG+ + D V G Y+APE I + Y D Sbjct: 181 KPSNVLINALGQVKMCDFGISGYLV-DSVAKTIDAGCKPYMAPERINPELNQKGYSVKSD 239 Query: 524 WWAFGVLLYEMLAGQAPF--EGEDEDELFQSIMEHNVAYP-KSMSKEAVAICKGLMTKHP 580 W+ G+ + E+ + P+ G +L Q + E + P S E V + K+ Sbjct: 240 IWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNS 299 Query: 581 GKRLGCGPEGERDIKEHAFF 600 +R ++ +H FF Sbjct: 300 KERPT-----YPELMQHPFF 314 >4H1J-A nrPDB Length = 293 Score = 222 bits (565), Expect = 5e-58, Method: Composition-based stats. Identities = 54/252 (21%), Positives = 109/252 (43%), Gaps = 11/252 (4%) Query: 339 LTDFNFLMVLGKGSFGKVMLSE---RKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 395 D +LG+G FG+V KG AVK KKD + + E M E ++ Sbjct: 23 REDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNK--EKFMSEAVIMK 80 Query: 396 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR-FKEPHAVFYAAEIAIGL 454 P + +L + + +ME G+L +++++ K V Y+ +I + Sbjct: 81 -NLDHPHIVKLIGIIEEEPT-WIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAM 138 Query: 455 FFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTP-DYIAPEII 513 +L+S ++RD+ + N+++ S +K+ DFG+ + + + P +++PE I Sbjct: 139 AYLESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPESI 198 Query: 514 AYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIMEH-NVAYPKSMSKEAVAI 571 ++ + + D W F V ++E+L+ G+ PF + ++ + + + P + Sbjct: 199 NFRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTL 258 Query: 572 CKGLMTKHPGKR 583 P R Sbjct: 259 MTRCWDYDPSDR 270 >1U54-B nrPDB Length = 291 Score = 222 bits (565), Expect = 5e-58, Method: Composition-based stats. Identities = 65/259 (25%), Positives = 111/259 (42%), Gaps = 12/259 (4%) Query: 337 MKLTDFNFLMVLGKGSFGKVMLSERKG-TDELY--AVKILKKDVVIQDDDVECTMVEKRV 393 + D L LG GSFG V E + + AVK LK DV+ Q + ++ + E Sbjct: 15 IGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNA 74 Query: 394 LALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQV-GRFKEPHAVFYAAEIAI 452 + L +L+ T + V E G L+ +++ G F YA ++A Sbjct: 75 M-HSLDHRNLIRLYGVVLT-PPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAE 132 Query: 453 GLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTT---KTFCGTPDYIA 509 G+ +L+SK I+RDL N++L + +KI DFG+ + + + + A Sbjct: 133 GMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCA 192 Query: 510 PEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIME--HNVAYPKSMSK 566 PE + + + + D W FGV L+EM GQ P+ G + ++ I + + P+ + Sbjct: 193 PESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQ 252 Query: 567 EAVAICKGLMTKHPGKRLG 585 + + P R Sbjct: 253 DIYNVMVQCWAHKPEDRPT 271 >4GS6-A nrPDB Length = 315 Score = 221 bits (564), Expect = 6e-58, Method: Composition-based stats. Identities = 62/267 (23%), Positives = 118/267 (44%), Gaps = 25/267 (9%) Query: 341 DFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKP 400 + V+G+G+FG V ++ + + A+K ++ + + + +VE R L+ Sbjct: 10 EIEVEEVVGRGAFGVVCKAKWRA--KDVAIKQIE-----SESERKAFIVELRQLSRVN-H 61 Query: 401 PFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRF---KEPHAVFYAAEIAIGLFFL 457 P + +L+ + + VMEY GG L + HA+ + + + G+ +L Sbjct: 62 PNIVKLYGACL--NPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYL 119 Query: 458 QS---KGIIYRDLKLDNVMLDSEGHI-KIADFGMCKENIWDGVTTKTFCGTPDYIAPEII 513 S K +I+RDLK N++L + G + KI DFG + G+ ++APE+ Sbjct: 120 HSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDI---QTHMTNNKGSAAWMAPEVF 176 Query: 514 AYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYP---KSMSKEAVA 570 Y + D +++G++L+E++ + PF+ HN P K++ K + Sbjct: 177 EGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIES 236 Query: 571 ICKGLMTKHPGKRLGCGPEGERDIKEH 597 + +K P +R E I H Sbjct: 237 LMTRCWSKDPSQRPSM--EEIVKIMTH 261 >3KUL-B nrPDB Length = 325 Score = 221 bits (563), Expect = 8e-58, Method: Composition-based stats. Identities = 59/281 (20%), Positives = 111/281 (39%), Gaps = 17/281 (6%) Query: 317 PEEKTANTISKFDNNGN-----RDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDE---LY 368 PE + ++ G ++ + + ++G G G+V + + Sbjct: 21 PEPQFYAEPHTYEEPGRAGRSFTREIEASRIHIEKIIGSGDSGEVCYGRLRVPGQRDVPV 80 Query: 369 AVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDL 428 A+K LK + + E ++ P + +L V EY+ G L Sbjct: 81 AIKALKAGYT--ERQRRDFLSEASIMGQFD-HPNIIRLEGVVTRGRLAMIVTEYMENGSL 137 Query: 429 MYHIQQV-GRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGM 487 ++ G+F V + G+ +L G ++RDL NV++DS K++DFG+ Sbjct: 138 DTFLRTHDGQFTIMQLVGMLRGVGAGMRYLSDLGYVHRDLAARNVLVDSNLVCKVSDFGL 197 Query: 488 CKENIWDGVTTKTFCG---TPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEG 543 + D T G + APE IA++ + + D W+FGV+++E+LA G+ P+ Sbjct: 198 SRVLEDDPDAAYTTTGGKIPIRWTAPEAIAFRTFSSASDVWSFGVVMWEVLAYGERPYWN 257 Query: 544 EDEDELFQSIMEH-NVAYPKSMSKEAVAICKGLMTKHPGKR 583 ++ S+ E + P + K +R Sbjct: 258 MTNRDVISSVEEGYRLPAPMGCPHALHQLMLDCWHKDRAQR 298 >3I81-A nrPDB Length = 315 Score = 220 bits (562), Expect = 1e-57, Method: Composition-based stats. Identities = 62/304 (20%), Positives = 120/304 (39%), Gaps = 25/304 (8%) Query: 332 GNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDE-----LYAVKILKKDVVIQDDDVEC 386 + + LG+GSFG V KG + A+K + + +++ Sbjct: 10 PDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERI--E 67 Query: 387 TMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKE------ 440 + E V+ + +L +ME + GDL +++ + E Sbjct: 68 FLNEASVMKEFNCH-HVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLA 126 Query: 441 ----PHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGV 496 + A EIA G+ +L + ++RDL N M+ + +KI DFGM ++ Sbjct: 127 PPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDY 186 Query: 497 TTKTFCGTP--DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSI 553 K G +++PE + + D W+FGV+L+E+ + P++G +++ + + Sbjct: 187 YRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFV 246 Query: 554 MEHN-VAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKE--HAFFRYIDWEKLER 610 ME + P + + + +P R E IKE FR + + E Sbjct: 247 MEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFL-EIISSIKEEMEPGFREVSFYYSEE 305 Query: 611 KEIQ 614 +++ Sbjct: 306 NKME 309 >3ORP-A nrPDB Length = 311 Score = 220 bits (561), Expect = 1e-57, Method: Composition-based stats. Identities = 65/266 (24%), Positives = 109/266 (40%), Gaps = 12/266 (4%) Query: 340 TDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK 399 + +LG G +V L+ AVK+L+ D+ E + A Sbjct: 12 DRYELGEILGFGGMSEVHLARDLRDHRDVAVKVLRADLARDPSFYLRFRREAQN-AAALN 70 Query: 400 PPFLTQLHSCFQTMDR----LYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 455 P + ++ + Y VMEYV+G L + G A+ A+ L Sbjct: 71 HPAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIVHTEGPMTPKRAIEVIADACQALN 130 Query: 456 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDG---VTTKTFCGTPDYIAPEI 512 F GII+RD+K N+M+ + +K+ DFG+ + G T GT Y++PE Sbjct: 131 FSHQNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGTAQYLSPEQ 190 Query: 513 IAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDEL-FQSIMEHNV---AYPKSMSKEA 568 D ++ G +LYE+L G+ PF G+ + +Q + E + A + +S + Sbjct: 191 ARGDSVDARSDVYSLGCVLYEVLTGEPPFTGDSPVSVAYQHVREDPIPPSARHEGLSADL 250 Query: 569 VAICKGLMTKHPGKRLGCGPEGERDI 594 A+ + K+P R E D+ Sbjct: 251 DAVVLKALAKNPENRYQTAAEMRADL 276 >3EQC-A nrPDB Length = 360 Score = 220 bits (560), Expect = 2e-57, Method: Composition-based stats. Identities = 68/319 (21%), Positives = 125/319 (39%), Gaps = 55/319 (17%) Query: 336 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 395 +K DF + LG G+ G V K + + A K++ ++ + ++ + + Sbjct: 29 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEI---KPAIRNQIIRELQVL 85 Query: 396 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 455 P++ + F + + ME+++GG L +++ GR E + + GL Sbjct: 86 HECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLT 145 Query: 456 FL-QSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA 514 +L + I++RD+K N++++S G IK+ DFG+ + I +F GT Y++PE + Sbjct: 146 YLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS--MANSFVGTRSYMSPERLQ 203 Query: 515 YQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDED--------------------------- 547 Y D W+ G+ L EM G+ P D Sbjct: 204 GTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRP 263 Query: 548 ---------------ELFQSIM-EHNVAYPKSM-SKEAVAICKGLMTKHPGKRLGCGPEG 590 EL I+ E P + S E + K+P +R Sbjct: 264 LNKFGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERA-----D 318 Query: 591 ERDIKEHAFFRYIDWEKLE 609 + + HAF + D E+++ Sbjct: 319 LKQLMVHAFIKRSDAEEVD 337 >5NGU-A nrPDB Length = 381 Score = 220 bits (560), Expect = 2e-57, Method: Composition-based stats. Identities = 61/316 (19%), Positives = 122/316 (38%), Gaps = 49/316 (15%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 + L +G+G++G V + A+K + + T+ E ++L Sbjct: 44 YTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISP--FEHQTYCQRTLREIKILLRFRHEN 101 Query: 402 FL----TQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFL 457 + + M +Y V + + DL + + H ++ +I GL ++ Sbjct: 102 IIGINDIIRAPTIEQMKDVYIVQDLMET-DLYKLL-KTQHLSNDHICYFLYQILRGLKYI 159 Query: 458 QSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTT---KTFCGTPDYIAPEI-I 513 S +++RDLK N++L++ +KI DFG+ + D T + T Y APEI + Sbjct: 160 HSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIML 219 Query: 514 AYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSI-------------------- 553 + Y KS+D W+ G +L EML+ + F G+ + I Sbjct: 220 NSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKA 279 Query: 554 MEHNVAYP-----------KSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRY 602 + ++ P + +A+ + ++T +P KR+ H + Sbjct: 280 RNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRI-----EVEQALAHPYLEQ 334 Query: 603 IDWEKLERKEIQPPYK 618 ++ + + P+K Sbjct: 335 Y-YDPSDEPIAEAPFK 349 >6FEX-A nrPDB Length = 321 Score = 220 bits (560), Expect = 2e-57, Method: Composition-based stats. Identities = 68/283 (24%), Positives = 113/283 (39%), Gaps = 44/283 (15%) Query: 342 FNFLMVLGKGSFGKVMLSE----------------RKGTDELYAVKILKKDVVIQDDDVE 385 F LG+G FG+V L E RKG L AVKIL+ D + Sbjct: 18 LRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDAT--KNARN 75 Query: 386 CTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVG--------- 436 + E ++++ P + L C Q D L + +Y+ GDL + Sbjct: 76 DFLKEVKIMSRLKDPNIIRLLGVCVQD-DPLCMITDYMENGDLNQFLSAHQLEDKAAEGA 134 Query: 437 ----RFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENI 492 P + AA+IA G+ +L + ++RDL N ++ IKIADFGM + Sbjct: 135 PGDPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLY 194 Query: 493 -WDGVTTKTFCGTP-DYIAPEIIAYQPYGKSVDWWAFGVLLYE--MLAGQAPFEGEDEDE 548 D + P ++A E I + + D WAFGV L+E ML PF +++ Sbjct: 195 AGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQ 254 Query: 549 LFQSI--------MEHNVAYPKSMSKEAVAICKGLMTKHPGKR 583 + ++ + ++ P + + + ++ +R Sbjct: 255 VIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQR 297 >4QTB-A nrPDB Length = 380 Score = 219 bits (559), Expect = 3e-57, Method: Composition-based stats. Identities = 71/351 (20%), Positives = 132/351 (37%), Gaps = 59/351 (16%) Query: 307 RAKIGQGTKAPEEKTANTISKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDE 366 R G G P E FD + L +G+G++G V + Sbjct: 16 RRTEGVGPGVPGEVEMVKGQPFDVGPR--------YTQLQYIGEGAYGMVSSAYDHVRKT 67 Query: 367 LYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFL----TQLHSCFQTMDRLYFVMEY 422 A+K + + T+ E ++L + S + M +Y V + Sbjct: 68 RVAIKKISP--FEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDL 125 Query: 423 VNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKI 482 + DL ++ + H ++ +I GL ++ S +++RDLK N+++++ +KI Sbjct: 126 MET-DLYKLLKS-QQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKI 183 Query: 483 ADFGMCKENIWDGVTT---KTFCGTPDYIAPEI-IAYQPYGKSVDWWAFGVLLYEMLAGQ 538 DFG+ + + T + T Y APEI + + Y KS+D W+ G +L EML+ + Sbjct: 184 CDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNR 243 Query: 539 APFEGE---------------DEDELFQSIMEHNVA-----------------YPKSMSK 566 F G+ E I+ +PKS SK Sbjct: 244 PIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSK 303 Query: 567 EAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPY 617 A+ + ++T +P KR+ + H + ++ + + P+ Sbjct: 304 -ALDLLDRMLTFNPNKRIT-----VEEALAHPYLEQY-YDPTDEPVAEEPF 347 >4NST-A nrPDB Length = 351 Score = 219 bits (559), Expect = 3e-57, Method: Composition-based stats. Identities = 66/328 (20%), Positives = 131/328 (39%), Gaps = 54/328 (16%) Query: 339 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 398 + F+ + ++G+G++G+V ++ K T EL A+K ++ D + + + E ++L Sbjct: 12 VDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPI-TAIREIKILRQLI 70 Query: 399 KPPFLTQL---------HSCFQTMDRLYFVMEYVNGGDLMYHIQQ-VGRFKEPHAVFYAA 448 + + Y V EY++ DLM ++ + F E H + Sbjct: 71 HRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDH-DLMGLLESGLVHFSEDHIKSFMK 129 Query: 449 EIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTF-CGTPDY 507 ++ GL + K ++RD+K N++L++ G IK+ADFG+ + + T T Y Sbjct: 130 QLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWY 189 Query: 508 IAPEIIAY-QPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSI------------- 553 PE++ + Y ++D W+ G +L E+ + F+ E + I Sbjct: 190 RPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWP 249 Query: 554 ----------MEHNVAYPK-------SMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKE 596 M+ Y + + A+ + ++T P KR + D + Sbjct: 250 DVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLK 309 Query: 597 HAFFRYIDWEKLERKEIQPPYKPKARDK 624 +E ++ PP P +D Sbjct: 310 ----------DVELSKMAPPDLPHWQDC 327 >5EFQ-A nrPDB Length = 347 Score = 219 bits (558), Expect = 3e-57, Method: Composition-based stats. Identities = 67/328 (20%), Positives = 130/328 (39%), Gaps = 54/328 (16%) Query: 339 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 398 + F+ + ++G+G++G+V + K T E+ A+K ++ D + + + E ++L Sbjct: 10 VDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPI-TAIREIKILRQLT 68 Query: 399 KPPFLTQLHSCFQTMDRL---------YFVMEYVNGGDLMYHIQQ-VGRFKEPHAVFYAA 448 + D L Y V EY++ DLM ++ + F E H + Sbjct: 69 HQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDH-DLMGLLESGLVHFNENHIKSFMR 127 Query: 449 EIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTF-CGTPDY 507 ++ GL + K ++RD+K N++L++ G IK+ADFG+ + + T T Y Sbjct: 128 QLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWY 187 Query: 508 IAPEIIAY-QPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSI------------- 553 PE++ + Y ++D W+ G +L E+ + F+ E + I Sbjct: 188 RPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWP 247 Query: 554 ----------MEHNVAYPK-------SMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKE 596 M+ Y + + A+ + ++ P KR + Sbjct: 248 DVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTA-----EQALQ 302 Query: 597 HAFFRYIDWEKLERKEIQPPYKPKARDK 624 F R + E ++ PP P +D Sbjct: 303 CEFLRDV-----EPSKMPPPDLPLWQDC 325 >3FME-A nrPDB Length = 290 Score = 219 bits (557), Expect = 4e-57, Method: Composition-based stats. Identities = 62/277 (22%), Positives = 113/277 (40%), Gaps = 21/277 (7%) Query: 336 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 395 +K D +M LG+G++G V + ++ AVK ++ + + + +++ + Sbjct: 3 EVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIR--ATVNSQEQKRLLMDLDISM 60 Query: 396 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYH----IQQVGRFKEPHAVFYAAEIA 451 PF + ++ ME ++ L I + E A I Sbjct: 61 RTVDCPFTVTFYGALFREGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIV 119 Query: 452 IGLFFLQSK-GIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAP 510 L L SK +I+RD+K NV++++ G +K+ DFG+ + D V G Y+AP Sbjct: 120 KALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLV-DDVAKDIDAGCKPYMAP 178 Query: 511 EII----AYQPYGKSVDWWAFGVLLYEMLAGQAPF--EGEDEDELFQSIMEHNVAYP-KS 563 E I + Y D W+ G+ + E+ + P+ G +L Q + E + P Sbjct: 179 ERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADK 238 Query: 564 MSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFF 600 S E V + K+ +R ++ +H FF Sbjct: 239 FSAEFVDFTSQCLKKNSKERPT-----YPELMQHPFF 270 >4MYG-A nrPDB Length = 372 Score = 218 bits (556), Expect = 5e-57, Method: Composition-based stats. Identities = 63/292 (21%), Positives = 115/292 (39%), Gaps = 51/292 (17%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 407 +G G++G V + K + E A+K L + + + E +L + + L Sbjct: 51 VGSGAYGSVCSAIDKRSGEKVAIKKLSR-PFQSEIFAKRAYRELLLLKHM-QHENVIGLL 108 Query: 408 SCFQTMDRL------YFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKG 461 F L Y VM ++ DL + F E + ++ GL ++ S G Sbjct: 109 DVFTPASSLRNFYDFYLVMPFMQT-DLQKIM--GMEFSEEKIQYLVYQMLKGLKYIHSAG 165 Query: 462 IIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEII-AYQPYGK 520 +++RDLK N+ ++ + +KI DFG+ + + + T Y APE+I ++ Y + Sbjct: 166 VVHRDLKPGNLAVNEDCELKILDFGLARHADAE---MTGYVVTRWYRAPEVILSWMHYNQ 222 Query: 521 SVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHN----------------------- 557 +VD W+ G ++ EML G+ F+G+D + I++ Sbjct: 223 TVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSL 282 Query: 558 VAYPKS--------MSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFR 601 P+ S +A + + ++ KRL H FF Sbjct: 283 PQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAA-----QALTHPFFE 329 >1U5R-A nrPDB Length = 348 Score = 218 bits (555), Expect = 8e-57, Method: Composition-based stats. Identities = 68/298 (22%), Positives = 107/298 (35%), Gaps = 22/298 (7%) Query: 312 QGTKAPEEKTANTISKFDNNGNRDRMKLTD---FNFLMVLGKGSFGKVMLSERKGTDELY 368 QG P S D + K F+ L +G GSFG V + E+ Sbjct: 23 QGAMDPMPAGGRAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVV 82 Query: 369 AVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGG-- 426 A+K + ++ + + E R L + P Q C+ + VMEY G Sbjct: 83 AIKKMSYSGKQSNEKWQDIIKEVRFLQKL-RHPNTIQYRGCYLREHTAWLVMEYCLGSAS 141 Query: 427 DLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFG 486 DL+ +E GL +L S +I+RD+K N++L G +K+ DFG Sbjct: 142 DLLEV--HKKPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFG 199 Query: 487 MCKENIWDGVTTKTFCGTPDYIAPEIIAYQP---YGKSVDWWAFGVLLYEMLAGQAPFEG 543 +F GTP ++APE+I Y VD W+ G+ E+ + P Sbjct: 200 SASIMAP----ANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFN 255 Query: 544 EDEDELFQSIMEHNVA--YPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAF 599 + I ++ S+ + K P R + +H F Sbjct: 256 MNAMSALYHIAQNESPALQSGHWSEYFRNFVDSCLQKIPQDRPT-----SEVLLKHRF 308 >5HI2-A nrPDB Length = 283 Score = 218 bits (555), Expect = 8e-57, Method: Composition-based stats. Identities = 67/279 (24%), Positives = 120/279 (43%), Gaps = 24/279 (8%) Query: 330 NNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMV 389 ++ + + +G GSFG V + G AVK+L ++ Sbjct: 10 DSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD---VAVKML------TPQQLQAFKN 60 Query: 390 EKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQ-QVGRFKEPHAVFYAA 448 E VL L L + T +L V ++ G L +H+ +F+ + A Sbjct: 61 EVGVLRKTRHVNIL--LFMGYSTKPQLAIVTQWCEGSSLYHHLHASETKFEMKKLIDIAR 118 Query: 449 EIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMC--KENIWDGVTTKTFCGTPD 506 + A G+ +L +K II+RDLK +N+ L + +KI DFG+ K + G+ Sbjct: 119 QTARGMDYLHAKSIIHRDLKSNNIFLHEDNTVKIGDFGLATVKSRWSGSHQFEQLSGSIL 178 Query: 507 YIAPEIIAYQ---PYGKSVDWWAFGVLLYEMLAGQAPFEGEDE-DELFQSIMEHNVAYP- 561 ++APE+I Q PY D +AFG++LYE++ GQ P+ + D++ + + +++ Sbjct: 179 WMAPEVIRMQDSNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEMVGRGSLSPDL 238 Query: 562 ----KSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKE 596 + K + + K +R P +I+E Sbjct: 239 SKVRSNCPKRMKRLMAECLKKKRDERPS-FPRILAEIEE 276 >6BSD-A nrPDB Length = 876 Score = 217 bits (554), Expect = 9e-57, Method: Composition-based stats. Identities = 69/289 (23%), Positives = 114/289 (39%), Gaps = 50/289 (17%) Query: 342 FNFLMVLGKGSFGKVMLSE----------------RKGTDELYAVKILKKDVVIQDDDVE 385 F LG+G FG+V L E RKG L AVKIL+ D + Sbjct: 573 LRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDAT--KNARN 630 Query: 386 CTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQ------------ 433 + E ++++ P + L C Q D L + +Y+ GDL + Sbjct: 631 DFLKEVKIMSRLKDPNIIRLLGVCVQD-DPLCMITDYMENGDLNQFLSAHQLEDKAAEGA 689 Query: 434 -------QVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFG 486 Q P + AA+IA G+ +L + ++RDL N ++ IKIADFG Sbjct: 690 PGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFG 749 Query: 487 MCKENI-WDGVTTKTFCGTP-DYIAPEIIAYQPYGKSVDWWAFGVLLYE--MLAGQAPFE 542 M + D + P ++A E I + + D WAFGV L+E ML PF Sbjct: 750 MSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFG 809 Query: 543 GEDEDELFQSI--------MEHNVAYPKSMSKEAVAICKGLMTKHPGKR 583 ++++ ++ + ++ P + + + ++ +R Sbjct: 810 QLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQR 858 >3QUP-A nrPDB Length = 323 Score = 217 bits (552), Expect = 1e-56, Method: Composition-based stats. Identities = 70/277 (25%), Positives = 121/277 (43%), Gaps = 23/277 (8%) Query: 342 FNFLMVLGKGSFGKVMLSERK---GTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 398 F +LGKG FG V ++ K G+ AVK+LK D +I D+E + E + Sbjct: 25 FTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKAD-IIASSDIEEFLREAACMKEFD 83 Query: 399 KPPFLTQLHSCFQT--MDRL---YFVMEYVNGGDLMYHIQQVG------RFKEPHAVFYA 447 P + ++ RL ++ ++ GDL + V + Sbjct: 84 HPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLVRFM 143 Query: 448 AEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGT--- 504 +IA G+ +L S+ I+RDL N ML + + +ADFG+ ++ I+ G + C + Sbjct: 144 VDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRK-IYSGDYYRQGCASKLP 202 Query: 505 PDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIMEHN-VAYPK 562 ++A E +A Y D WAFGV ++E++ GQ P+ G + E++ ++ N + P Sbjct: 203 VKWLALESLADNLYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPP 262 Query: 563 SMSKEAVAICKGLMTKHPGKR--LGCGPEGERDIKEH 597 +E + + P +R C +I H Sbjct: 263 ECMEEVYDLMYQCWSADPKQRPSFTCLRMELENILGH 299 >2GCD-A nrPDB Length = 309 Score = 217 bits (552), Expect = 2e-56, Method: Composition-based stats. Identities = 62/265 (23%), Positives = 100/265 (37%), Gaps = 19/265 (7%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 F+ L +G GSFG V + E+ A+K + ++ + + E R L + P Sbjct: 17 FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKL-RHP 75 Query: 402 FLTQLHSCFQTMDRLYFVMEYVNGG--DLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQS 459 Q C+ + VMEY G DL+ +E GL +L S Sbjct: 76 NTIQYRGCYLREHTAWLVMEYCLGSASDLLEV--HKKPLQEVEIAAVTHGALQGLAYLHS 133 Query: 460 KGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQP-- 517 +I+RD+K N++L G +K+ DFG +F GTP ++APE+I Sbjct: 134 HNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAP----ANSFVGTPYWMAPEVILAMDEG 189 Query: 518 -YGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVA--YPKSMSKEAVAICKG 574 Y VD W+ G+ E+ + P + I ++ S+ Sbjct: 190 QYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPALQSGHWSEYFRNFVDS 249 Query: 575 LMTKHPGKRLGCGPEGERDIKEHAF 599 + K P R + +H F Sbjct: 250 CLQKIPQDRPT-----SEVLLKHRF 269 >5AWM-A nrPDB Length = 394 Score = 216 bits (551), Expect = 2e-56, Method: Composition-based stats. Identities = 69/374 (18%), Positives = 134/374 (35%), Gaps = 72/374 (19%) Query: 318 EEKTANTISKFDNNGNRDRMKLTDFNF------LMVLGKGSFGKVMLSERKGTDELYAVK 371 + T++ + + T+F L +G G+ G V + T + A+K Sbjct: 16 PRGSHRTMTTAQHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIK 75 Query: 372 ILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSC-----FQTMDRLYFVMEYVNGG 426 L + + E +++ L + L++ + +Y VME ++ Sbjct: 76 KLSR-PFQNVTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDA- 133 Query: 427 DLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFG 486 +L IQ + ++ G+ L S GII+RDLK N+++ ++ +KI DFG Sbjct: 134 NLCQVIQ--MDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFG 191 Query: 487 MCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDE 546 + + + T Y APE+I Y ++VD W+ G ++ EM+ G F G D Sbjct: 192 LARTA-GTTFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDH 250 Query: 547 DELFQSIMEH-------------------------------NVAYPKSMSK--------- 566 + + I+E + +P + Sbjct: 251 IDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRR 310 Query: 567 ---EAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARD 623 +A + ++ P +R+ + +H + W E + P + Sbjct: 311 KASDARNLLSKMLVIDPEQRIS-----VDEALKHEYIN--VWYDAEEVDAPAP------E 357 Query: 624 KRDTSNFDKEFTRQ 637 D S ++E T + Sbjct: 358 PYDHSVDEREHTVE 371 >3OMV-A nrPDB Length = 307 Score = 216 bits (550), Expect = 3e-56, Method: Composition-based stats. Identities = 72/308 (23%), Positives = 128/308 (41%), Gaps = 24/308 (7%) Query: 310 IGQGTKAPEEKTANTISKFDNNGNRD-----RMKLTDFNFLMVLGKGSFGKVMLSERKGT 364 + +G+ +K G RD ++ ++ +G GSFG V + G Sbjct: 1 MDRGSHHHHHHGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGD 60 Query: 365 DELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVN 424 AVKILK V + + E VL L L + T D L V ++ Sbjct: 61 ---VAVKILKV-VDPTPEQFQAFRNEVAVLRKTRHVNIL--LFMGYMTKDNLAIVTQWCE 114 Query: 425 GGDLMYHIQ-QVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIA 483 G L H+ Q +F+ + A + A G+ +L +K II+RD+K +N+ L +KI Sbjct: 115 GSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIG 174 Query: 484 DFGMC--KENIWDGVTTKTFCGTPDYIAPEIIAYQ---PYGKSVDWWAFGVLLYEMLAGQ 538 DFG+ K + G+ ++APE+I Q P+ D +++G++LYE++ G+ Sbjct: 175 DFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGE 234 Query: 539 APFEGEDEDELFQSIMEHNVAYPK------SMSKEAVAICKGLMTKHPGKR-LGCGPEGE 591 P+ + + ++ A P + K + + K +R L Sbjct: 235 LPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSS 294 Query: 592 RDIKEHAF 599 ++ +H+ Sbjct: 295 IELLQHSL 302 >3BBT-B nrPDB Length = 328 Score = 216 bits (550), Expect = 3e-56, Method: Composition-based stats. Identities = 59/264 (22%), Positives = 110/264 (41%), Gaps = 13/264 (4%) Query: 329 DNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELY----AVKILKKDVVIQDDDV 384 N +K T+ + VLG G+FG V E A+KIL + +V Sbjct: 4 PNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILN-ETTGPKANV 62 Query: 385 ECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVG-RFKEPHA 443 E M E ++A P + L C + V + + G L+ ++ + Sbjct: 63 E-FMDEALIMASMDHPHLVRLLGVCLS--PTIQLVTQLMPHGCLLEYVHEHKDNIGSQLL 119 Query: 444 VFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCG 503 + + +IA G+ +L+ + +++RDL NV++ S H+KI DFG+ + D G Sbjct: 120 LNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGG 179 Query: 504 --TPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIMEHN-VA 559 ++A E I Y+ + D W++GV ++E++ G P++G E+ + + + Sbjct: 180 KMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLP 239 Query: 560 YPKSMSKEAVAICKGLMTKHPGKR 583 P + + + R Sbjct: 240 QPPICTIDVYMVMVKCWMIDADSR 263 >4EQM-A nrPDB Length = 294 Score = 216 bits (550), Expect = 3e-56, Method: Composition-based stats. Identities = 60/259 (23%), Positives = 106/259 (40%), Gaps = 7/259 (2%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 + + LG G V L+E + A+K + +++ ++ E + Sbjct: 13 YKIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETLKRFEREVHNSSQLS-HQ 71 Query: 402 FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKG 461 + + + D Y VMEY+ G L +I+ G A+ + +I G+ Sbjct: 72 NIVSMIDVDEEDDCYYLVMEYIEGPTLSEYIESHGPLSVDTAINFTNQILDGIKHAHDMR 131 Query: 462 IIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVT-TKTFCGTPDYIAPEIIAYQPYGK 520 I++RD+K N+++DS +KI DFG+ K +T T GT Y +PE + + Sbjct: 132 IVHRDIKPQNILIDSNKTLKIFDFGIAKALSETSLTQTNHVLGTVQYFSPEQAKGEATDE 191 Query: 521 SVDWWAFGVLLYEMLAGQAPFEGEDE-----DELFQSIMEHNVAYPKSMSKEAVAICKGL 575 D ++ G++LYEML G+ PF GE + S+ K + + + Sbjct: 192 CTDIYSIGIVLYEMLVGEPPFNGETAVSIAIKHIQDSVPNVTTDVRKDIPQSLSNVILRA 251 Query: 576 MTKHPGKRLGCGPEGERDI 594 K R E + D+ Sbjct: 252 TEKDKANRYKTIQEMKDDL 270 >3GC9-A nrPDB Length = 370 Score = 215 bits (549), Expect = 3e-56, Method: Composition-based stats. Identities = 79/333 (23%), Positives = 129/333 (38%), Gaps = 52/333 (15%) Query: 345 LMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLT 404 L +G G++G V + + AVK L + T E R+L K + Sbjct: 33 LRPVGSGAYGSVCSAYDARLRQKVAVKKLSR-PFQSLIHARRTYRELRLLKHL-KHENVI 90 Query: 405 QLHSCF------QTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQ 458 L F + +Y V + G DL I + + H F ++ GL ++ Sbjct: 91 GLLDVFTPATSIEDFSEVYLVTTLM-GADLNN-IVKSQALSDEHVQFLVYQLLRGLKYIH 148 Query: 459 SKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEI-IAYQP 517 S GII+RDLK NV ++ + ++I DFG+ ++ + T Y APEI + + Sbjct: 149 SAGIIHRDLKPSNVAVNEDSELRILDFGLARQA---DEEMTGYVATRWYRAPEIMLNWMH 205 Query: 518 YGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIM----------------EHNVAYP 561 Y ++VD W+ G ++ E+L G+A F G D + + IM EH Y Sbjct: 206 YNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYI 265 Query: 562 KSMSKE---------------AVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWE 606 +S+ A+ + ++ +R+ + HA+F + Sbjct: 266 QSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAA-----EALAHAYFS--QYH 318 Query: 607 KLERKEIQPPYKPKARDKRDTSNFDKEFTRQPV 639 E + PY K T KE T Q V Sbjct: 319 DPEDEPEAEPYDESVEAKERTLEEWKELTYQEV 351 >2WTK-C nrPDB Length = 305 Score = 215 bits (549), Expect = 4e-56, Method: Composition-based stats. Identities = 82/298 (27%), Positives = 141/298 (47%), Gaps = 21/298 (7%) Query: 339 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 398 + + +LG+GS+GKV T AVKILKK + + + E + ++ L Sbjct: 4 IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRL 63 Query: 399 KPPFLTQLHSCF--QTMDRLYFVMEYVNGG--DLMYHIQQVGRFKEPHAVFYAAEIAIGL 454 + + QL + ++Y VMEY G +++ + + RF A Y ++ GL Sbjct: 64 RHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPE-KRFPVCQAHGYFCQLIDGL 122 Query: 455 FFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKEN--IWDGVTTKTFCGTPDYIAPEI 512 +L S+GI+++D+K N++L + G +KI+ G+ + T +T G+P + PEI Sbjct: 123 EYLHSQGIVHKDIKPGNLLLTTGGTLKISALGVAEALHPFAADDTCRTSQGSPAFQPPEI 182 Query: 513 IAYQPY--GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVA 570 G VD W+ GV LY + G PFEG++ +LF++I + + A P Sbjct: 183 ANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSD 242 Query: 571 ICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPY-KPKARDKRDT 627 + KG++ P KR R I++H++FR + + P P + D +D Sbjct: 243 LLKGMLEYEPAKRFSI-----RQIRQHSWFRK------KHPPAEAPVPIPPSPDTKDR 289 >3E7O-A nrPDB Length = 360 Score = 215 bits (549), Expect = 4e-56, Method: Composition-based stats. Identities = 66/326 (20%), Positives = 114/326 (34%), Gaps = 61/326 (18%) Query: 339 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 398 L + L +G G+ G V + AVK L + Q+ + VL Sbjct: 21 LKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSR--PFQNQTHAKRAYRELVLLKCV 78 Query: 399 KPPFLTQLHSCFQTMDRL------YFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAI 452 + L + F L Y VME ++ +L I + ++ Sbjct: 79 NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIH--MELDHERMSYLLYQMLC 135 Query: 453 GLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEI 512 G+ L S GII+RDLK N+++ S+ +KI DFG+ + + T Y APE+ Sbjct: 136 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA-STNFMMTPYVVTRYYRAPEV 194 Query: 513 IAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEH---------------- 556 I Y ++VD W+ G ++ E++ G F+G D + + ++E Sbjct: 195 ILGMGYKENVDIWSVGCIMGELVKGSVIFQGTDHIDQWNKVIEQLGTPSAEFMAALQPTV 254 Query: 557 ---------------NVAYPKSM-----------SKEAVAICKGLMTKHPGKRLGCGPEG 590 +P + + +A + ++ P KR+ Sbjct: 255 RNYVENRPAYPGIAFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRIS----- 309 Query: 591 ERDIKEHAFFRYIDWEKLERKEIQPP 616 + H + W E PP Sbjct: 310 VDEALRHPYI--TVWYDPAEAEAPPP 333 >3DLS-A nrPDB Length = 335 Score = 215 bits (547), Expect = 6e-56, Method: Composition-based stats. Identities = 73/279 (26%), Positives = 131/279 (46%), Gaps = 16/279 (5%) Query: 340 TDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMV-----EKRVL 394 ++ + LG G+FG V + K ++ VK +KK+ V++D +E + E +L Sbjct: 24 QKYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAIL 83 Query: 395 ALPGKPPFLTQLHSCFQTMDRLYFVME-YVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIG 453 + + + ++ F+ VME + +G DL I + R EP A + ++ Sbjct: 84 SRV-EHANIIKVLDIFENQGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASYIFRQLVSA 142 Query: 454 LFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEII 513 + +L+ K II+RD+K +N+++ + IK+ DFG + G TFCGT +Y APE++ Sbjct: 143 VGYLRLKDIIHRDIKDENIVIAEDFTIKLIDFGSA-AYLERGKLFYTFCGTIEYCAPEVL 201 Query: 514 AYQPY-GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAIC 572 PY G ++ W+ GV LY ++ + PF + +E + P +SKE +++ Sbjct: 202 MGNPYRGPELEMWSLGVTLYTLVFEENPFCE------LEETVEAAIHPPYLVSKELMSLV 255 Query: 573 KGLMTKHPGKRLGCGPEGERDIKEHAF-FRYIDWEKLER 610 GL+ P +R WE++ R Sbjct: 256 SGLLQPVPERRTTLEKLVTDPWVTQPVNLADYTWEEVFR 294 >1JNK-A nrPDB Length = 423 Score = 215 bits (547), Expect = 6e-56, Method: Composition-based stats. Identities = 69/326 (21%), Positives = 116/326 (35%), Gaps = 61/326 (18%) Query: 339 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 398 L + L +G G+ G V + D A+K L + Q+ + VL Sbjct: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSR--PFQNQTHAKRAYRELVLMKCV 118 Query: 399 KPPFLTQLHSCFQTMDRL------YFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAI 452 + L + F L Y VME ++ +L IQ + ++ Sbjct: 119 NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQ--MELDHERMSYLLYQMLC 175 Query: 453 GLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEI 512 G+ L S GII+RDLK N+++ S+ +KI DFG+ + + T Y APE+ Sbjct: 176 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA-GTSFMMTPYVVTRYYRAPEV 234 Query: 513 IAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEH---------------- 556 I Y ++VD W+ G ++ EM+ + F G D + + ++E Sbjct: 235 ILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTV 294 Query: 557 -----------NVAYPKSMSK---------------EAVAICKGLMTKHPGKRLGCGPEG 590 + +PK +A + ++ P KR+ Sbjct: 295 RNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS----- 349 Query: 591 ERDIKEHAFFRYIDWEKLERKEIQPP 616 D +H + W E PP Sbjct: 350 VDDALQHPYIN--VWYDPAEVEAPPP 373 >5U6B-A nrPDB Length = 307 Score = 214 bits (546), Expect = 8e-56, Method: Composition-based stats. Identities = 65/270 (24%), Positives = 111/270 (41%), Gaps = 19/270 (7%) Query: 344 FLMVLGKGSFGKVMLSERKGTD--ELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 LG+G FG VM + D AVK +K + ++E + E + P Sbjct: 27 LGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMK-IAICTRSELEDFLSEAVCMKEFDHPN 85 Query: 402 FLTQLHSCFQTMDR-----LYFVMEYVNGGDLMYHI------QQVGRFKEPHAVFYAAEI 450 + + CFQ +R ++ ++ GDL + Q V + A+I Sbjct: 86 VMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADI 145 Query: 451 AIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCG--TPDYI 508 A G+ +L +K I+RDL N ML+ + +ADFG+ K+ + +I Sbjct: 146 ASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWI 205 Query: 509 APEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIMEHN-VAYPKSMSK 566 A E +A + Y D W+FGV ++E+ GQ P+ G + E++ + + N + P Sbjct: 206 AIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLD 265 Query: 567 EAVAICKGLMTKHPGKRLGCGPEGERDIKE 596 A+ +P R E D++ Sbjct: 266 GLYALMSRCWELNPQDRPSFT-ELREDLEN 294 >3C1X-A nrPDB Length = 373 Score = 214 bits (546), Expect = 9e-56, Method: Composition-based stats. Identities = 63/253 (24%), Positives = 109/253 (43%), Gaps = 12/253 (4%) Query: 343 NFLMVLGKGSFGKVMLSE---RKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK 399 +F V+G+G FG V G AVK L + I + V + E ++ Sbjct: 92 HFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGE--VSQFLTEGIIMKDFSH 149 Query: 400 PPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQ-QVGRFKEPHAVFYAAEIAIGLFFLQ 458 P L+ L C ++ V+ Y+ GDL I+ + + + ++A G+ FL Sbjct: 150 PNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKFLA 209 Query: 459 SKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIW---DGVTTKTFCGTP-DYIAPEIIA 514 SK ++RDL N MLD + +K+ADFG+ ++ D V KT P ++A E + Sbjct: 210 SKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEFDSVHNKTGAKLPVKWMALESLQ 269 Query: 515 YQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIMEH-NVAYPKSMSKEAVAIC 572 Q + D W+FGVLL+E++ G P+ + ++ +++ + P+ + Sbjct: 270 TQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVM 329 Query: 573 KGLMTKHPGKRLG 585 R Sbjct: 330 LKCWHPKAEMRPS 342 >5AIR-A nrPDB Length = 430 Score = 214 bits (546), Expect = 9e-56, Method: Composition-based stats. Identities = 78/376 (20%), Positives = 142/376 (37%), Gaps = 61/376 (16%) Query: 306 ERAKIGQGTKAPEEKTANTISKFDNNGN-RDRMKLTDFNFLMVLGKGSFGKVMLSERKGT 364 + + G + ++ + + G DR + + V+G GSFG V ++ + Sbjct: 29 QPSAFGSMKVSIDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDS 88 Query: 365 DELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCF---QTMDRLYF--V 419 EL A+K + +D ++ E +++ + + + + D +Y V Sbjct: 89 GELVAIKKVLQDKRFKN-------RELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLV 141 Query: 420 MEYVN---GGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDS 476 ++YV ++ + + Y ++ L ++ S GI +RD+K N++LD Sbjct: 142 LDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDP 201 Query: 477 E-GHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAY-QPYGKSVDWWAFGVLLYEM 534 + +K+ DFG K+ + C + Y APE+I Y S+D W+ G +L E+ Sbjct: 202 DTAVLKLCDFGSAKQLVRGEPNVSYIC-SRYYRAPELIFGATDYTSSIDVWSAGCVLAEL 260 Query: 535 LAGQAPFEGEDEDELF------------QSIMEHN-----VAYP------------KSMS 565 L GQ F G+ + + I E N +P Sbjct: 261 LLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTP 320 Query: 566 KEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKR 625 EA+A+C L+ P RL H+FF ++L ++ P RD Sbjct: 321 PEAIALCSRLLEYTPTARLTPLEACA-----HSFF-----DELRDPNVK---LPNGRDTP 367 Query: 626 DTSNFDKEFTRQPVEL 641 NF + L Sbjct: 368 ALFNFTTQELSSNPPL 383 >1TKI-A nrPDB Length = 321 Score = 214 bits (546), Expect = 9e-56, Method: Composition-based stats. Identities = 62/270 (22%), Positives = 115/270 (42%), Gaps = 18/270 (6%) Query: 340 TDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK 399 + LG+G FG V + + Y K +K ++ D E +L + + Sbjct: 5 EKYMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVK----VKGTDQVLVKKEISILNIA-R 59 Query: 400 PPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVG-RFKEPHAVFYAAEIAIGLFFLQ 458 + LH F++M+ L + E+++G D+ I E V Y ++ L FL Sbjct: 60 HRNILHLHESFESMEELVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCEALQFLH 119 Query: 459 SKGIIYRDLKLDNVMLDSE--GHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQ 516 S I + D++ +N++ + IKI +FG ++ G + P+Y APE+ + Sbjct: 120 SHNIGHFDIRPENIIYQTRRSSTIKIIEFGQARQL-KPGDNFRLLFTAPEYYAPEVHQHD 178 Query: 517 PYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYP----KSMSKEAVAIC 572 + D W+ G L+Y +L+G PF E ++ ++IM + K +S EA+ Sbjct: 179 VVSTATDMWSLGTLVYVLLSGINPFLAETNQQIIENIMNAEYTFDEEAFKEISIEAMDFV 238 Query: 573 KGLMTKHPGKRLGCGPEGERDIKEHAFFRY 602 L+ K R+ + +H + + Sbjct: 239 DRLLVKERKSRMTAS-----EALQHPWLKQ 263 >3LZB-A nrPDB Length = 327 Score = 214 bits (545), Expect = 1e-55, Method: Composition-based stats. Identities = 56/266 (21%), Positives = 115/266 (43%), Gaps = 13/266 (4%) Query: 327 KFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELY----AVKILKKDVVIQDD 382 + N +K T+F + VLG G+FG V E A+K L++ + + Sbjct: 2 EAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKAN 61 Query: 383 DVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVG-RFKEP 441 + + E V+A P L C + + + + + G L+ ++++ Sbjct: 62 --KEILDEAYVMASVDNPHVCRLLGICLTST--VQLITQLMPFGCLLDYVREHKDNIGSQ 117 Query: 442 HAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTF 501 + + + +IA G+ +L+ + +++RDL NV++ + H+KI DFG+ K + Sbjct: 118 YLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAE 177 Query: 502 CG--TPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIMEHN- 557 G ++A E I ++ Y D W++GV ++E++ G P++G E+ + + Sbjct: 178 GGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGER 237 Query: 558 VAYPKSMSKEAVAICKGLMTKHPGKR 583 + P + + I + R Sbjct: 238 LPQPPICTIDVYMIMRKCWMIDADSR 263 >4E7W-A nrPDB Length = 394 Score = 214 bits (544), Expect = 1e-55, Method: Composition-based stats. Identities = 76/356 (21%), Positives = 133/356 (37%), Gaps = 58/356 (16%) Query: 305 FERAKIGQGTKAPEEKTANTISKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGT 364 A + P + I ++G + + V+G GSFG V ++ + Sbjct: 5 MSNAPLNGVKLNPLDDPNKVIKVLASDGKTGEQREIAYTNCKVIGNGSFGVVFQAKLVES 64 Query: 365 DELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDR------LYF 418 DE A+K + +D ++ +++ + K P + L + F + L Sbjct: 65 DE-VAIKKVLQDKRFKNRELQ--------IMRIVKHPNVVDLKAFFYSNGDKKDEVFLNL 115 Query: 419 VMEYVN---GGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLD 475 V+EYV ++ + Y ++ L ++ S GI +RD+K N++LD Sbjct: 116 VLEYVPETVYRASRHYAKLKQTMPMLLIKLYMYQLLRSLAYIHSIGICHRDIKPQNLLLD 175 Query: 476 -SEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQP-YGKSVDWWAFGVLLYE 533 G +K+ DFG K I C + Y APE+I Y ++D W+ G ++ E Sbjct: 176 PPSGVLKLIDFGSAKILIAGEPNVSYIC-SRYYRAPELIFGATNYTTNIDIWSTGCVMAE 234 Query: 534 MLAGQAPFEGED-EDELFQSI------------------MEHNVA----------YPKSM 564 ++ GQ F GE D+L + I MEH + Sbjct: 235 LMQGQPLFPGESGIDQLVEIIKVLGTPSREQIKTMNPNYMEHKFPQIRPHPFSKVFRPRT 294 Query: 565 SKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFF---RYIDWEKLERKEIQPPY 617 +A+ + L+ P RL + H FF R + +E+ P + Sbjct: 295 PPDAIDLISRLLEYTPSARLTA-----IEALCHPFFDELRTGEARMPNGRELPPLF 345 >5HIE-A nrPDB Length = 302 Score = 213 bits (543), Expect = 2e-55, Method: Composition-based stats. Identities = 66/280 (23%), Positives = 117/280 (41%), Gaps = 24/280 (8%) Query: 316 APEEKTANTISKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKK 375 + + T+ + D++ + + +G GSFG V + G AVK+L Sbjct: 13 SEDRNRMKTLGRRDSS-DDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD---VAVKML-- 66 Query: 376 DVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQ- 434 ++ E VL L L + T +L V ++ G L +H+ Sbjct: 67 ----TPQQLQAFKNEVGVLRKTRHVNIL--LFMGYSTKPQLAIVTQWCEGSSLYHHLHII 120 Query: 435 VGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMC--KENI 492 +F+ + A + A G+ +L +K II+RDLK +N+ L + +KI DFG+ K Sbjct: 121 ETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRW 180 Query: 493 WDGVTTKTFCGTPDYIAPEIIAYQ---PYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDEL 549 + G+ ++APE+I Q PY D +AFG++LYE++ GQ P+ + + Sbjct: 181 SGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQ 240 Query: 550 FQSIMEHNVAYPK------SMSKEAVAICKGLMTKHPGKR 583 ++ P + K + + K +R Sbjct: 241 IIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDER 280 >3PP0-A nrPDB Length = 338 Score = 213 bits (543), Expect = 2e-55, Method: Composition-based stats. Identities = 60/264 (22%), Positives = 114/264 (43%), Gaps = 13/264 (4%) Query: 329 DNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELY----AVKILKKDVVIQDDDV 384 N +K T+ + VLG G+FG V E A+K+L+++ + + Sbjct: 6 PNQALLRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKAN-- 63 Query: 385 ECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQ-VGRFKEPHA 443 + + E V+A G P L C + + V + + G L+ H+++ GR Sbjct: 64 KEILDEAYVMAGVGSPYVSRLLGICLTST--VQLVTQLMPYGCLLDHVRENRGRLGSQDL 121 Query: 444 VFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCG 503 + + +IA G+ +L+ +++RDL NV++ S H+KI DFG+ + D G Sbjct: 122 LNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGG 181 Query: 504 --TPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIMEHN-VA 559 ++A E I + + D W++GV ++E++ G P++G E+ + + + Sbjct: 182 KVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLP 241 Query: 560 YPKSMSKEAVAICKGLMTKHPGKR 583 P + + I R Sbjct: 242 QPPICTIDVYMIMVKCWMIDSECR 265 >5GNK-A nrPDB Length = 297 Score = 213 bits (543), Expect = 2e-55, Method: Composition-based stats. Identities = 57/266 (21%), Positives = 115/266 (43%), Gaps = 13/266 (4%) Query: 327 KFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELY----AVKILKKDVVIQDD 382 + N +K T+F + VLG G+FG V E A+K L++ + + Sbjct: 6 EAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKAN 65 Query: 383 DVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVG-RFKEP 441 + + E V+A P L C + + +M+ + G L+ ++++ Sbjct: 66 --KEILDEAYVMASVDNPHVCRLLGICLTST--VQLIMQLMPFGCLLDYVREHKDNIGSQ 121 Query: 442 HAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTF 501 + + + +IA G+ +L+ + +++RDL NV++ + H+KI DFG+ K + Sbjct: 122 YLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAE 181 Query: 502 CG--TPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIMEHN- 557 G ++A E I ++ Y D W++GV ++E++ G P++G E+ + + Sbjct: 182 GGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGER 241 Query: 558 VAYPKSMSKEAVAICKGLMTKHPGKR 583 + P + + I R Sbjct: 242 LPQPPICTIDVYMIMVKCWMIDADSR 267 >3FI2-A nrPDB Length = 353 Score = 212 bits (541), Expect = 3e-55, Method: Composition-based stats. Identities = 65/310 (20%), Positives = 112/310 (36%), Gaps = 59/310 (19%) Query: 339 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 398 L + L +G G+ G V + D A+K L + Q+ + VL Sbjct: 23 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSR--PFQNQTHAKRAYRELVLMKCV 80 Query: 399 KPPFLTQLHSCFQTMDRL------YFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAI 452 + L + F L Y VME ++ +L IQ + ++ Sbjct: 81 NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQ--MELDHERMSYLLYQMLC 137 Query: 453 GLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEI 512 G+ L S GII+RDLK N+++ S+ +KI DFG+ + + T Y APE+ Sbjct: 138 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA-GTSFMMTPYVVTRYYRAPEV 196 Query: 513 IAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEH---------------- 556 I Y ++VD W+ G ++ EM+ + F G D + + ++E Sbjct: 197 ILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTV 256 Query: 557 -----------NVAYPKSMSK---------------EAVAICKGLMTKHPGKRLGCGPEG 590 + +PK +A + ++ P KR+ Sbjct: 257 RNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS----- 311 Query: 591 ERDIKEHAFF 600 D +H + Sbjct: 312 VDDALQHPYI 321 >2XS0-A nrPDB Length = 386 Score = 212 bits (541), Expect = 3e-55, Method: Composition-based stats. Identities = 68/355 (19%), Positives = 123/355 (34%), Gaps = 61/355 (17%) Query: 313 GTKAPEEKTANTISKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKI 372 G+ + ++ N S G+ L + L +G G+ G V + + A+K Sbjct: 1 GSMSRSKRDNNFYSV--EIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKK 58 Query: 373 LKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHS-----CFQTMDRLYFVMEYVNGGD 427 L + + E ++ + L+ + +Y VME ++ + Sbjct: 59 LSR-PFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDA-N 116 Query: 428 LMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGM 487 L IQ + ++ G+ L S GII+RDLK N+++ S+ +KI DFG+ Sbjct: 117 LCQVIQ--MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGL 174 Query: 488 CKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDED 547 + F T Y APE+I Y ++VD W+ G ++ EM+ G F G D Sbjct: 175 ARTA-GTSFMMVPFVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHI 233 Query: 548 ELFQSIMEHNVA-------------------------------YPKSMSK---------- 566 + + ++E +P + Sbjct: 234 DQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKA 293 Query: 567 -EAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPK 620 +A + ++ KR+ + +H + W E PP P Sbjct: 294 SQARDLLSKMLVIDASKRIS-----VDEALQHPYIN--VWYDPSEAEAPPPKIPD 341 >5HLW-A nrPDB Length = 299 Score = 212 bits (540), Expect = 4e-55, Method: Composition-based stats. Identities = 60/253 (23%), Positives = 108/253 (42%), Gaps = 12/253 (4%) Query: 343 NFLMVLGKGSFGKVMLSE---RKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK 399 +F V+G+G FG V G AVK L + I + V + E ++ Sbjct: 23 HFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGE--VSQFLTEGIIMKDFSH 80 Query: 400 PPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQ-QVGRFKEPHAVFYAAEIAIGLFFLQ 458 P L+ L C ++ V+ Y+ GDL I+ + + + ++A G+ +L Sbjct: 81 PNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLA 140 Query: 459 SKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTT---KTFCGTP-DYIAPEIIA 514 SK ++RDL N MLD + +K+ADFG+ ++ + KT P ++A E + Sbjct: 141 SKKFVHRDLAARNCMLDEKFTVKVADFGLARDMHDKEYYSVHNKTGAKLPVKWMALESLQ 200 Query: 515 YQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIMEH-NVAYPKSMSKEAVAIC 572 Q + D W+FGVLL+E++ G P+ + ++ +++ + P+ + Sbjct: 201 TQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVM 260 Query: 573 KGLMTKHPGKRLG 585 R Sbjct: 261 LKCWHPKAEMRPS 273 >1S9I-A nrPDB Length = 354 Score = 212 bits (539), Expect = 5e-55, Method: Composition-based stats. Identities = 62/323 (19%), Positives = 126/323 (39%), Gaps = 59/323 (18%) Query: 336 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 395 +K DF + LG G+ G V + + + + A K++ ++ + ++ + + Sbjct: 12 ELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEI---KPAIRNQIIRELQVL 68 Query: 396 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 455 P++ + F + + ME+++GG L +++ R E + + GL Sbjct: 69 HECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLA 128 Query: 456 FL-QSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA 514 +L + I++RD+K N++++S G IK+ DFG+ + I +F GT Y+APE + Sbjct: 129 YLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS--MANSFVGTRSYMAPERLQ 186 Query: 515 YQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELF----QSIMEHNVAYPKSMS----- 565 Y D W+ G+ L E+ G+ P D EL + +++ P S+S Sbjct: 187 GTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRP 246 Query: 566 ---------------------------------------KEAVAICKGLMTKHPGKRLGC 586 + + K+P +R Sbjct: 247 PGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERA-- 304 Query: 587 GPEGERDIKEHAFFRYIDWEKLE 609 + + H F + + E+++ Sbjct: 305 ---DLKMLTNHTFIKRSEVEEVD 324 >1U59-A nrPDB Length = 287 Score = 211 bits (537), Expect = 1e-54, Method: Composition-based stats. Identities = 64/259 (24%), Positives = 113/259 (43%), Gaps = 16/259 (6%) Query: 333 NRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDEL--YAVKILKKDVVIQDDDVECTMVE 390 RD + + D LG G+FG V + + A+K+LK+ + D E M E Sbjct: 7 KRDNLLIADIE----LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGT--EKADTEEMMRE 60 Query: 391 KRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQ-QVGRFKEPHAVFYAAE 449 +++ P++ +L Q L VME GG L + + + + Sbjct: 61 AQIMHQLDN-PYIVRLIGVCQAE-ALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQ 118 Query: 450 IAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDG--VTTKTFCGTP-D 506 +++G+ +L+ K ++RDL NV+L + + KI+DFG+ K D T ++ P Sbjct: 119 VSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLK 178 Query: 507 YIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIMEHN-VAYPKSM 564 + APE I ++ + D W++GV ++E L+ GQ P++ E+ I + + P Sbjct: 179 WYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPEC 238 Query: 565 SKEAVAICKGLMTKHPGKR 583 E A+ R Sbjct: 239 PPELYALMSDCWIYKWEDR 257 >3BGP-A nrPDB Length = 333 Score = 210 bits (536), Expect = 1e-54, Method: Composition-based stats. Identities = 69/279 (24%), Positives = 123/279 (44%), Gaps = 20/279 (7%) Query: 332 GNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMV-- 389 G + + +LG G FG V R + A+K ++KD + ++ Sbjct: 48 GKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVP 107 Query: 390 EKRVLALPGKPPF--LTQLHSCFQTMDRLYFVME-YVNGGDLMYHIQQVGRFKEPHAVFY 446 + VL F + +L F+ D ++E DL I + G +E A + Sbjct: 108 MEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSF 167 Query: 447 AAEIAIGLFFLQSKGIIYRDLKLDNVMLD-SEGHIKIADFGMCKENIWDGVTTKTFCGTP 505 ++ + + G+++RD+K +N+++D + G +K+ DFG + D V T F GT Sbjct: 168 FWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFG-SGALLKDTVYT-DFDGTR 225 Query: 506 DYIAPEIIAYQPY-GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSM 564 Y PE I Y Y G+S W+ G+LLY+M+ G PFE ++E I+ V + + + Sbjct: 226 VYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE------IIRGQVFFRQRV 279 Query: 565 SKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYI 603 S E + + + P R +I+ H + + + Sbjct: 280 SSECQHLIRWCLALRPSDRPT-----FEEIQNHPWMQDV 313 >2W96-B nrPDB Length = 306 Score = 210 bits (535), Expect = 2e-54, Method: Composition-based stats. Identities = 60/296 (20%), Positives = 115/296 (38%), Gaps = 46/296 (15%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVEC-TMVEKRVLALPG-- 398 + + +G G++G V + + A+K ++ V ++ + T+ E +L Sbjct: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVR--VPNGEEGLPISTVREVALLRRLEAF 63 Query: 399 KPPFLTQLHSCFQTMD-----RLYFVMEYVNGGDLMYHIQQVGR--FKEPHAVFYAAEIA 451 + P + +L T ++ V E+V+ DL ++ + + Sbjct: 64 EHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQFL 122 Query: 452 IGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPE 511 GL FL + I++RDLK +N+++ S G +K+ADFG+ + + T Y APE Sbjct: 123 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLAR-IYSYQMALDPVVVTLWYRAPE 181 Query: 512 IIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIME---------------- 555 ++ Y VD W+ G + EM + F G E + I + Sbjct: 182 VLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSL 241 Query: 556 HNVAYPK-------SMSKEAVA----ICKGLMTKHPGKRLGCGPEGERDIKEHAFF 600 A+P S+ E + ++T +P KR+ +H++ Sbjct: 242 PRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFR-----ALQHSYL 292 >1ZXE-A nrPDB Length = 303 Score = 210 bits (534), Expect = 2e-54, Method: Composition-based stats. Identities = 57/281 (20%), Positives = 113/281 (40%), Gaps = 42/281 (14%) Query: 340 TDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK 399 +DF + VLG+G+FG+V+ + YA+K ++ ++ + + E +L Sbjct: 6 SDFEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRH----TEEKLSTILSEV-MLLASLN 60 Query: 400 PPFLTQLHSCF-------------QTMDRLYFVMEYVNGGDLMYHIQQVG-RFKEPHAVF 445 ++ + ++ + + L+ MEY L I + Sbjct: 61 HQYVVRYYAAWLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQRDEYWR 120 Query: 446 YAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCK--------------EN 491 +I L ++ S+GII+R+LK N+ +D ++KI DFG+ K Sbjct: 121 LFRQILEALSYIHSQGIIHRNLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKLDSQNL 180 Query: 492 IWDGVTTKTFCGTPDYIAPEIIAY-QPYGKSVDWWAFGVLLYEMLAGQAPFE-GEDEDEL 549 + GT Y+A E++ Y + +D ++ G++ +EM+ PF G + + Sbjct: 181 PGSSDNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMI---YPFSTGMERVNI 237 Query: 550 FQSIMEHNVAYPKSMSKEA----VAICKGLMTKHPGKRLGC 586 + + ++ +P I + L+ P KR G Sbjct: 238 LKKLRSVSIEFPPDFDDNKMKVEKKIIRLLIDHDPNKRPGA 278 >5B2L-A nrPDB Length = 324 Score = 210 bits (534), Expect = 2e-54, Method: Composition-based stats. Identities = 68/285 (23%), Positives = 124/285 (43%), Gaps = 22/285 (7%) Query: 332 GNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEK 391 G R + ++ D L +G G+ G+V + T + AVK +++ ++ + +++ Sbjct: 9 GQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSG--NKEENKRILMDL 66 Query: 392 RVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQV--GRFKEPHAVFYAAE 449 V+ P++ Q F T ++ ME + G +++ G E Sbjct: 67 DVVLKSHDCPYIVQCFGTFITNTDVFIAMELM--GTSAEKLKKRMQGPIPERILGKMTVA 124 Query: 450 IAIGLFFL-QSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYI 508 I L++L + G+I+RD+K N++LD G IK+ DFG+ + T++ G Y+ Sbjct: 125 IVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRS-AGCAAYM 183 Query: 509 APEII-----AYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDED-ELFQSIMEHNVA-YP 561 APE I Y D W+ G+ L E+ GQ P++ D E+ +++ P Sbjct: 184 APERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLP 243 Query: 562 KSM--SKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYID 604 M S + + K +TK KR + EH+F + + Sbjct: 244 GHMGFSGDFQSFVKDCLTKDHRKR-----PKYNKLLEHSFIKRYE 283 >5TUR-A nrPDB Length = 404 Score = 210 bits (534), Expect = 2e-54, Method: Composition-based stats. Identities = 69/279 (24%), Positives = 123/279 (44%), Gaps = 20/279 (7%) Query: 332 GNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMV-- 389 G + + +LG G FG V R + A+K ++KD + ++ Sbjct: 119 GKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVP 178 Query: 390 EKRVLALPGKPPF--LTQLHSCFQTMDRLYFVME-YVNGGDLMYHIQQVGRFKEPHAVFY 446 + VL F + +L F+ D ++E DL I + G +E A + Sbjct: 179 MEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSF 238 Query: 447 AAEIAIGLFFLQSKGIIYRDLKLDNVMLD-SEGHIKIADFGMCKENIWDGVTTKTFCGTP 505 ++ + + G+++RD+K +N+++D + G +K+ DFG + D V T F GT Sbjct: 239 FWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFG-SGALLKDTVYT-DFDGTR 296 Query: 506 DYIAPEIIAYQPY-GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSM 564 Y PE I Y Y G+S W+ G+LLY+M+ G PFE ++E I+ V + + + Sbjct: 297 VYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE------IIRGQVFFRQRV 350 Query: 565 SKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYI 603 S E + + + P R +I+ H + + + Sbjct: 351 SSECQHLIRWCLALRPSDRPT-----FEEIQNHPWMQDV 384 >4IDT-A nrPDB Length = 356 Score = 209 bits (532), Expect = 3e-54, Method: Composition-based stats. Identities = 76/305 (24%), Positives = 124/305 (40%), Gaps = 35/305 (11%) Query: 308 AKIGQGTKAPEEKTANTISKFDNNGN--RDRMKLTDFNFLMV---------LGKGSFGKV 356 A G ++ P KT DN G +++K D+ + LG+GSFG+V Sbjct: 37 AARGSRSREPSPKTE------DNEGVLLTEKLKPVDYEYREEVHWATHQLRLGRGSFGEV 90 Query: 357 MLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRL 416 E K T AVK ++ +E E+ + P + L+ + + Sbjct: 91 HRMEDKQTGFQCAVKKVR---------LEVFRAEELMACAGLTSPRIVPLYGAVREGPWV 141 Query: 417 YFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDS 476 ME + GG L +++ G E A++Y + GL +L S+ I++ D+K DNV+L S Sbjct: 142 NIFMELLEGGSLGQLVKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVKADNVLLSS 201 Query: 477 EG-HIKIADFGMCKENIWDG-----VTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVL 530 +G H + DFG DG +T GT ++APE++ + VD W+ + Sbjct: 202 DGSHAALCDFGHAVCLQPDGLGKDLLTGDYIPGTETHMAPEVVLGRSCDAKVDVWSSCCM 261 Query: 531 LYEMLAGQAPFEGEDEDELFQSIMEHNV---AYPKSMSKEAVAICKGLMTKHPGKRLGCG 587 + ML G P+ L I P S + + + K P R+ Sbjct: 262 MLHMLNGCHPWTQFFRGPLCLKIASEPPPVREIPPSCAPLTAQAIQEGLRKEPIHRVSAA 321 Query: 588 PEGER 592 G + Sbjct: 322 ELGGK 326 >4LRM-A nrPDB Length = 334 Score = 209 bits (532), Expect = 3e-54, Method: Composition-based stats. Identities = 57/268 (21%), Positives = 116/268 (43%), Gaps = 14/268 (5%) Query: 327 KFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELY----AVKILKKDVVIQDD 382 + N +K T+F + VLG G+FG V E A+K L++ + + Sbjct: 6 EAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKAN 65 Query: 383 DVECTMVEKRVLALPGKP--PFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVG-RFK 439 + + E V+A P P + +L T + + + + G L+ ++++ Sbjct: 66 --KEILDEAYVMASVDNPGNPHVCRLLGICLTST-VQLITQLMPFGCLLDYVREHKDNIG 122 Query: 440 EPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTK 499 + + + +IA G+ +L+ + +++RDL NV++ + H+KI DFG+ K + Sbjct: 123 SQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYH 182 Query: 500 TFCG--TPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIMEH 556 G ++A E I ++ Y D W++GV ++E++ G P++G E+ + + Sbjct: 183 AEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKG 242 Query: 557 N-VAYPKSMSKEAVAICKGLMTKHPGKR 583 + P + + I R Sbjct: 243 ERLPQPPICTIDVYMIMVKCWMIDADSR 270 >4X7Q-B nrPDB Length = 312 Score = 209 bits (532), Expect = 4e-54, Method: Composition-based stats. Identities = 64/273 (23%), Positives = 119/273 (43%), Gaps = 22/273 (8%) Query: 339 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTM---VEKRVLA 395 ++ +LGKG FG V R A+K++ ++ V+ + ++ +E +L Sbjct: 30 EAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLW 89 Query: 396 LPG---KPPFLTQLHSCFQTMDRLYFVME-YVNGGDLMYHIQQVGRFKEPHAVFYAAEIA 451 G P + +L F+T + V+E + DL +I + G E + + ++ Sbjct: 90 KVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVV 149 Query: 452 IGLFFLQSKGIIYRDLKLDNVMLD-SEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAP 510 + S+G+++RD+K +N+++D G K+ DFG + F GT Y P Sbjct: 150 AAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFG--SGALLHDEPYTDFDGTRVYSPP 207 Query: 511 EIIAYQPY-GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAV 569 E I+ Y W+ G+LLY+M+ G PFE + Q I+E + +P +S + Sbjct: 208 EWISRHQYHALPATVWSLGILLYDMVCGDIPFERD------QEILEAELHFPAHVSPDCC 261 Query: 570 AICKGLMTKHPGKRLGCGPEGERDIKEHAFFRY 602 A+ + + P R +I + + Sbjct: 262 ALIRRCLAPKPSSRPSL-----EEILLDPWMQT 289 >2OZO-A nrPDB Length = 613 Score = 208 bits (530), Expect = 6e-54, Method: Composition-based stats. Identities = 63/259 (24%), Positives = 113/259 (43%), Gaps = 16/259 (6%) Query: 333 NRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDEL--YAVKILKKDVVIQDDDVECTMVE 390 RD + + D LG G+FG V + + A+K+LK+ + D E M E Sbjct: 333 KRDNLLIADIE----LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGT--EKADTEEMMRE 386 Query: 391 KRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQ-QVGRFKEPHAVFYAAE 449 +++ P++ +L Q L VME GG L + + + + Sbjct: 387 AQIMHQLDN-PYIVRLIGVCQAE-ALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQ 444 Query: 450 IAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDG--VTTKTFCGTP-D 506 +++G+ +L+ K ++R+L NV+L + + KI+DFG+ K D T ++ P Sbjct: 445 VSMGMKYLEEKNFVHRNLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLK 504 Query: 507 YIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIMEHN-VAYPKSM 564 + APE I ++ + D W++GV ++E L+ GQ P++ E+ I + + P Sbjct: 505 WYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPEC 564 Query: 565 SKEAVAICKGLMTKHPGKR 583 E A+ R Sbjct: 565 PPELYALMSDCWIYKWEDR 583 >1A25-A nrPDB Length = 149 Score = 208 bits (530), Expect = 6e-54, Method: Composition-based stats. Identities = 134/136 (98%), Positives = 134/136 (98%) Query: 154 DHTERRGRIYIQAHIDREVLIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTK 213 D ERRGRIYIQAHIDREVLIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTK Sbjct: 14 DSMERRGRIYIQAHIDREVLIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTK 73 Query: 214 TIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKAGVDG 273 TIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKAGVDG Sbjct: 74 TIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKAGVDG 133 Query: 274 WFKLLSQEEGEYFNVP 289 WFKLLSQEEGEYFNVP Sbjct: 134 WFKLLSQEEGEYFNVP 149 >5O2B-A nrPDB Length = 285 Score = 208 bits (529), Expect = 7e-54, Method: Composition-based stats. Identities = 66/269 (24%), Positives = 124/269 (46%), Gaps = 20/269 (7%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 F + LG+G+F V T A L +D + + + E +L + P Sbjct: 18 LKFDIELGRGAFKTVYKGLDTETWVEVAWCEL-QDRKLTKAEQQRFKEEAEMLK-GLQHP 75 Query: 402 FLTQLHSCFQT----MDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFL 457 + + + +++ + V E + G L ++++ K + +I GL FL Sbjct: 76 NIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFL 135 Query: 458 QSK--GIIYRDLKLDNVMLDSE-GHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA 514 ++ II+RDLK DN+ + G +KI D G+ + K+ GTP+++APE+ Sbjct: 136 HTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLAT--LMRTSFAKSVIGTPEFMAPEMYE 193 Query: 515 YQPYGKSVDWWAFGVLLYEMLAGQAPF-EGEDEDELFQSIMEH--NVAYPKSMSKEAVAI 571 + Y +SVD +AFG+ + EM + P+ E ++ ++++ + ++ K E I Sbjct: 194 -EHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKVTDPEVKEI 252 Query: 572 CKGLMTKHPGKRLGCGPEGERDIKEHAFF 600 +G + ++ +RL RD+ HAFF Sbjct: 253 IEGCIRQNKSERLSI-----RDLLNHAFF 276 >4RC3-A nrPDB Length = 289 Score = 208 bits (529), Expect = 8e-54, Method: Composition-based stats. Identities = 68/272 (25%), Positives = 122/272 (44%), Gaps = 20/272 (7%) Query: 339 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMV--EKRVLAL 396 + + +LG G FG V R + A+K ++KD + ++ + VL Sbjct: 11 ESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLK 70 Query: 397 PGKPPF--LTQLHSCFQTMDRLYFVME-YVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIG 453 F + +L F+ D ++E DL I + G +E A + ++ Sbjct: 71 KVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEA 130 Query: 454 LFFLQSKGIIYRDLKLDNVMLD-SEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEI 512 + + G+++RD+K +N+++D + G +K+ DFG + D V T F GT Y PE Sbjct: 131 VRHCHNCGVLHRDIKDENILIDLNRGELKLIDFG-SGALLKDTVYT-DFDGTRVYSPPEW 188 Query: 513 IAYQPY-GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAI 571 I Y Y G+S W+ G+LLY+M+ G PFE ++E I+ V + + +S E + Sbjct: 189 IRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE------IIRGQVFFRQRVSSECQHL 242 Query: 572 CKGLMTKHPGKRLGCGPEGERDIKEHAFFRYI 603 + + P R +I+ H + + + Sbjct: 243 IRWCLALRPSDRPT-----FEEIQNHPWMQDV 269 >5U6C-A nrPDB Length = 315 Score = 207 bits (527), Expect = 1e-53, Method: Composition-based stats. Identities = 61/259 (23%), Positives = 106/259 (40%), Gaps = 18/259 (6%) Query: 344 FLMVLGKGSFGKVMLSERK---GTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKP 400 +LG+G FG VM K GT AVK +K D Q ++E + E + P Sbjct: 40 LGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQR-EIEEFLSEAACMKDFSHP 98 Query: 401 PFLTQLHSCFQTM----DRLYFVMEYVNGGDLMYHIQQV------GRFKEPHAVFYAAEI 450 + L C + + ++ ++ GDL ++ + + +I Sbjct: 99 NVMRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDI 158 Query: 451 AIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCG--TPDYI 508 A+G+ +L ++ ++RDL N ML + + +ADFG+ K+ + +I Sbjct: 159 ALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWI 218 Query: 509 APEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIME-HNVAYPKSMSK 566 A E +A + Y D WAFGV ++E+ G P+ G E++ ++ H + P+ Sbjct: 219 AIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLD 278 Query: 567 EAVAICKGLMTKHPGKRLG 585 E I P R Sbjct: 279 ELYEIMYSCWRTDPLDRPT 297 >3AOX-A nrPDB Length = 344 Score = 207 bits (527), Expect = 1e-53, Method: Composition-based stats. Identities = 58/276 (21%), Positives = 107/276 (38%), Gaps = 22/276 (7%) Query: 327 KFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSE-----RKGTDELYAVKILKKDVVIQD 381 K + + + + + LG G+FG+V + + AVK L + V + Sbjct: 34 KTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPE--VCSE 91 Query: 382 DDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR---- 437 D ++E +++ + + Q++ R ++E + GGDL +++ Sbjct: 92 QDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRF-ILLELMAGGDLKSFLRETRPRPSQ 150 Query: 438 ---FKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEG---HIKIADFGMCKEN 491 + A +IA G +L+ I+RD+ N +L G KI DFGM ++ Sbjct: 151 PSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDI 210 Query: 492 IWDGVTTKTFCGTP--DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDE 548 K C ++ PE + D W+FGVLL+E+ + G P+ + E Sbjct: 211 YRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQE 270 Query: 549 LFQSIME-HNVAYPKSMSKEAVAICKGLMTKHPGKR 583 + + + + PK+ I P R Sbjct: 271 VLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDR 306 >3ALO-A nrPDB Length = 327 Score = 207 bits (526), Expect = 2e-53, Method: Composition-based stats. Identities = 57/279 (20%), Positives = 112/279 (40%), Gaps = 23/279 (8%) Query: 337 MKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLAL 396 D L +G+G++G V K + ++ AVK ++ + + + + +++ V+ Sbjct: 19 FTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIR--STVDEKEQKQLLMDLDVVMR 76 Query: 397 PGKPPFLTQLHSCFQTMDRLYFVMEYVNGG--DLMYHIQQV--GRFKEPHAVFYAAEIAI 452 P++ Q + + ME ++ ++ V E Sbjct: 77 SSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVK 136 Query: 453 GLFFLQSK-GIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPE 511 L L+ II+RD+K N++LD G+IK+ DFG+ + + T+ G Y+APE Sbjct: 137 ALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRD-AGCRPYMAPE 195 Query: 512 II----AYQPYGKSVDWWAFGVLLYEMLAGQAPFEG-EDEDELFQSIMEHNVAY-----P 561 I + Q Y D W+ G+ LYE+ G+ P+ + +++ + Sbjct: 196 RIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEE 255 Query: 562 KSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFF 600 + S + +TK KR +++ +H F Sbjct: 256 REFSPSFINFVNLCLTKDESKR-----PKYKELLKHPFI 289 >6FER-A nrPDB Length = 309 Score = 207 bits (526), Expect = 2e-53, Method: Composition-based stats. Identities = 61/282 (21%), Positives = 108/282 (38%), Gaps = 41/282 (14%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDE----------------LYAVKILKKDVVIQDDDVE 385 F LG+G FG+V L E +G ++ L AVK+L+ D + Sbjct: 11 LTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADA--NKNARN 68 Query: 386 CTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEP---- 441 + E ++++ P + L + T D L + EY+ GDL + + Sbjct: 69 DFLKEIKIMSRLKD-PNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPNSSSSDV 127 Query: 442 ------HAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIW-D 494 + F A +IA G+ +L S ++RDL N ++ IKIADFGM + D Sbjct: 128 RTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGD 187 Query: 495 GVTTKTFCGTP-DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA--GQAPFEGEDEDELFQ 551 + P +++ E I + + D WAFGV L+E + P+ ++++ + Sbjct: 188 YYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIE 247 Query: 552 SI--------MEHNVAYPKSMSKEAVAICKGLMTKHPGKRLG 585 + + + P + + R Sbjct: 248 NTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPS 289 >4PWN-A nrPDB Length = 274 Score = 206 bits (525), Expect = 2e-53, Method: Composition-based stats. Identities = 66/276 (23%), Positives = 124/276 (44%), Gaps = 22/276 (7%) Query: 340 TDFNFLM---VLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLAL 396 D FL +G+GSF V T A L +D + + + E +L Sbjct: 7 NDGRFLKFDIEIGRGSFKTVYKGLDTETTVEVAWCEL-QDRKLTKSERQRFKEEAEMLK- 64 Query: 397 PGKPPFLTQLHSCFQT----MDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAI 452 + P + + + +++ + V E + G L ++++ K + +I Sbjct: 65 GLQHPNIVRFYDSWESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILK 124 Query: 453 GLFFLQSK--GIIYRDLKLDNVMLDSE-GHIKIADFGMCKENIWDGVTTKTFCGTPDYIA 509 GL FL ++ II+RDLK DN+ + G +KI D G+ K+ GTP+++A Sbjct: 125 GLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLAT-LEKRASFAKSVIGTPEFMA 183 Query: 510 PEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPF-EGEDEDELFQSIMEH--NVAYPKSMSK 566 PE+ + Y +SVD +AFG+ + EM + P+ E ++ ++++ + ++ K Sbjct: 184 PEMYE-EKYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPASFDKVAIP 242 Query: 567 EAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRY 602 E I +G + ++ +R +D+ HAFF+ Sbjct: 243 EVKEIIEGCIRQNKDERYSI-----KDLLNHAFFQE 273 >3IO7-A nrPDB Length = 313 Score = 206 bits (525), Expect = 2e-53, Method: Composition-based stats. Identities = 66/280 (23%), Positives = 111/280 (39%), Gaps = 31/280 (11%) Query: 333 NRDRMKLTDFNFLMVLGKGSFGKVMLSERK----GTDELYAVKILKKDVVIQDDDVECTM 388 N + + FL LGKG+FG V + T E+ AVK L+ ++ + Sbjct: 21 NMTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHST---EEHLRDFE 77 Query: 389 VEKRVLALPGKPPFLTQLHSCFQTMDR--LYFVMEYVNGGDLMYHIQQVG-RFKEPHAVF 445 E +L + + + + R L +MEY+ G L ++Q+ R + Sbjct: 78 REIEILK-SLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQ 136 Query: 446 YAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKT---FC 502 Y ++I G+ +L +K I+RDL N+++++E +KI DFG+ K D K Sbjct: 137 YTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGE 196 Query: 503 GTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-----GQAP--FEGE-DEDELFQSIM 554 + APE + + + D W+FGV+LYE+ P F D+ Q I+ Sbjct: 197 SPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIV 256 Query: 555 ---------EHNVAYPKSMSKEAVAICKGLMTKHPGKRLG 585 + P E I + +R Sbjct: 257 FHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPS 296 >2W1I-A nrPDB Length = 326 Score = 206 bits (524), Expect = 3e-53, Method: Composition-based stats. Identities = 65/277 (23%), Positives = 110/277 (39%), Gaps = 31/277 (11%) Query: 336 RMKLTDFNFLMVLGKGSFGKVMLSERK----GTDELYAVKILKKDVVIQDDDVECTMVEK 391 + + FL LGKG+FG V + T E+ AVK L+ ++ + E Sbjct: 37 QFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHST---EEHLRDFEREI 93 Query: 392 RVLALPGKPPFLTQLHSCFQTMDR--LYFVMEYVNGGDLMYHIQQVG-RFKEPHAVFYAA 448 +L + + + + R L +MEY+ G L ++Q+ R + Y + Sbjct: 94 EILK-SLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTS 152 Query: 449 EIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKT---FCGTP 505 +I G+ +L +K I+RDL N+++++E +KI DFG+ K D K Sbjct: 153 QICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPI 212 Query: 506 DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-----GQAP--FEGE-DEDELFQSIM--- 554 + APE + + + D W+FGV+LYE+ P F D+ Q I+ Sbjct: 213 FWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHL 272 Query: 555 ------EHNVAYPKSMSKEAVAICKGLMTKHPGKRLG 585 + P E I + +R Sbjct: 273 IELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPS 309 >6GVJ-A nrPDB Length = 429 Score = 206 bits (524), Expect = 3e-53, Method: Composition-based stats. Identities = 57/305 (18%), Positives = 115/305 (37%), Gaps = 26/305 (8%) Query: 312 QGTKAPEEKTANTISKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVK 371 Q + + +K ++ L +G G KV ++YA+K Sbjct: 116 QHQILATPLQNLQVLASSSANECISVKGRIYSILKQIGSGGSSKVFQVLN-EKKQIYAIK 174 Query: 372 ILKKDVVIQDDDVECTMVEKRVLALPGKP-PFLTQLHSCFQTMDRLYFVMEYVNGGDLMY 430 + + + ++ E L + + +L+ T +Y VME DL Sbjct: 175 YVNLEE-ADNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVME-CGNIDLNS 232 Query: 431 HIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKE 490 +++ Y + + + GI++ DLK N ++ +G +K+ DFG+ + Sbjct: 233 WLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIV-DGMLKLIDFGIANQ 291 Query: 491 NIWD--GVTTKTFCGTPDYIAPEIIAYQPYGKS-----------VDWWAFGVLLYEMLAG 537 D V + GT +Y+ PE I + D W+ G +LY M G Sbjct: 292 MQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYG 351 Query: 538 QAPFEG-EDEDELFQSIME--HNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDI 594 + PF+ ++ +I++ H + +P K+ + K + + P +R+ ++ Sbjct: 352 KTPFQQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRISI-----PEL 406 Query: 595 KEHAF 599 H + Sbjct: 407 LAHPY 411 >6DBM-A nrPDB Length = 318 Score = 205 bits (523), Expect = 3e-53, Method: Composition-based stats. Identities = 68/283 (24%), Positives = 102/283 (36%), Gaps = 29/283 (10%) Query: 328 FDNNGNRDRMKLTDFNFLMVLGKGSFGKV----MLSERKGTDELYAVKILKKDVVIQDDD 383 F G+ + LG+G FGKV GT E+ AVK LK D Q Sbjct: 19 FQGPGDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAGPQHRS 78 Query: 384 VECTMVEKRVLALPGKPPFLTQLHSCFQTMD--RLYFVMEYVNGGDLMYHIQQVGRFKEP 441 E +L + + C + L VMEYV G L ++ + Sbjct: 79 GWKQ--EIDILRTL-YHEHIIKYKGCCEDAGAASLQLVMEYVPLGSLRDYLPRH-SIGLA 134 Query: 442 HAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTK-- 499 + +A +I G+ +L S+ I+RDL NV+LD++ +KI DFG+ K + Sbjct: 135 QLLLFAQQICEGMAYLHSQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVR 194 Query: 500 -TFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQ-----AP--F--------EG 543 + APE + + + D W+FGV LYE+L P F Sbjct: 195 EDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQ 254 Query: 544 EDEDELFQSIMEHN-VAYPKSMSKEAVAICKGLMTKHPGKRLG 585 L + + + P E + K R Sbjct: 255 MTVLRLTELLERGERLPRPDKCPAEVYHLMKNCWETEASFRPT 297 >5O2C-A nrPDB Length = 380 Score = 205 bits (523), Expect = 3e-53, Method: Composition-based stats. Identities = 66/269 (24%), Positives = 124/269 (46%), Gaps = 20/269 (7%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 F + LG+G+F V T A L +D + + + E +L + P Sbjct: 27 LKFDIELGRGAFKTVYKGLDTETWVEVAWCEL-QDRKLTKAEQQRFKEEAEMLK-GLQHP 84 Query: 402 FLTQLHSCFQT----MDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFL 457 + + + +++ + V E + G L ++++ K + +I GL FL Sbjct: 85 NIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFL 144 Query: 458 QSK--GIIYRDLKLDNVMLDSE-GHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA 514 ++ II+RDLK DN+ + G +KI D G+ + K+ GTP+++APE+ Sbjct: 145 HTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLAT--LMRTSFAKSVIGTPEFMAPEMYE 202 Query: 515 YQPYGKSVDWWAFGVLLYEMLAGQAPF-EGEDEDELFQSIMEH--NVAYPKSMSKEAVAI 571 + Y +SVD +AFG+ + EM + P+ E ++ ++++ + ++ K E I Sbjct: 203 -EHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKVTDPEVKEI 261 Query: 572 CKGLMTKHPGKRLGCGPEGERDIKEHAFF 600 +G + ++ +RL RD+ HAFF Sbjct: 262 IEGCIRQNKSERLSI-----RDLLNHAFF 285 >4YFF-A nrPDB Length = 311 Score = 205 bits (522), Expect = 5e-53, Method: Composition-based stats. Identities = 59/254 (23%), Positives = 112/254 (44%), Gaps = 9/254 (3%) Query: 337 MKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLAL 396 ++L++ F ++G GSFGKV + +++ A+K + + DV+ E +L Sbjct: 39 LQLSEIEFHEIIGSGSFGKVYKGRCR--NKIVAIKRYRANTYCSKSDVDMFCREVSILCQ 96 Query: 397 PGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR-FKEPHAVFYAAEIAIGLF 455 P + + +C + V +Y++GG L + + R + A ++A G+ Sbjct: 97 LNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGME 156 Query: 456 FLQ--SKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIW-DGVTTKTFCGTPDYIAPEI 512 +L ++ II+RDL N++L +GH +ADFG + D G ++APE+ Sbjct: 157 YLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEV 216 Query: 513 IAYQ-PYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYP--KSMSKEAV 569 Y D +++ + L+E+L G+ PF + H++ P S+ K Sbjct: 217 FTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPIS 276 Query: 570 AICKGLMTKHPGKR 583 ++ P R Sbjct: 277 SLLIRGWNACPEGR 290 >4OLI-A nrPDB Length = 645 Score = 204 bits (520), Expect = 9e-53, Method: Composition-based stats. Identities = 65/269 (24%), Positives = 99/269 (36%), Gaps = 29/269 (10%) Query: 342 FNFLMVLGKGSFGKV----MLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALP 397 + LG+G FGKV GT E+ AVK LK D Q E +L Sbjct: 355 LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQ--EIDILRTL 412 Query: 398 GKPPFLTQLHSCFQTMDR--LYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 455 + + C + L VMEYV G L ++ + + +A +I G+ Sbjct: 413 -YHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRH-SIGLAQLLLFAQQICEGMA 470 Query: 456 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTK---TFCGTPDYIAPEI 512 +L S+ I+R+L NV+LD++ +KI DFG+ K + + APE Sbjct: 471 YLHSQHYIHRNLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPEC 530 Query: 513 IAYQPYGKSVDWWAFGVLLYEMLAGQ-----AP--F--------EGEDEDELFQSIMEHN 557 + + + D W+FGV LYE+L P F L + + Sbjct: 531 LKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGE 590 Query: 558 -VAYPKSMSKEAVAICKGLMTKHPGKRLG 585 + P E + K R Sbjct: 591 RLPRPDKCPCEVYHLMKNCWETEASFRPT 619 Score = 109 bits (273), Expect = 4e-24, Method: Composition-based stats. Identities = 45/238 (18%), Positives = 85/238 (35%), Gaps = 20/238 (8%) Query: 359 SERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYF 418 +G + +K+L D+ E L L +H Sbjct: 88 GRDRGQELRVVLKVLDP----SHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIM 143 Query: 419 VMEYVNGGDLMYHIQQ-VGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSE 477 V EYV G L +++ G + A ++A L +L++K +++ ++ N++L Sbjct: 144 VTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARL 203 Query: 478 GH-------IKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQ--PYGKSVDWWAFG 528 G IK++D G ++ + ++APE + ++D W FG Sbjct: 204 GLAEGTSPFIKLSDPG----VGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFG 259 Query: 529 VLLYEM-LAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLG 585 L E+ G+AP + E + S + A + +T P +R Sbjct: 260 ATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLAT-LTSQCLTYEPTQRPS 316 >2I6L-A nrPDB Length = 320 Score = 204 bits (519), Expect = 1e-52, Method: Composition-based stats. Identities = 66/312 (21%), Positives = 119/312 (38%), Gaps = 58/312 (18%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 + L LG G G V + D+ A+K + V+ V+ + E +++ Sbjct: 13 YMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKI---VLTDPQSVKHALREIKIIRRLDHDN 69 Query: 402 FLTQLH-------------SCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAA 448 + ++ +Y V EY+ DL ++Q G E HA + Sbjct: 70 IVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMET-DLANVLEQ-GPLLEEHARLFMY 127 Query: 449 EIAIGLFFLQSKGIIYRDLKLDNVMLD-SEGHIKIADFGMCK---ENIWDGVTTKTFCGT 504 ++ GL ++ S +++RDLK N+ ++ + +KI DFG+ + + T Sbjct: 128 QLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVT 187 Query: 505 PDYIAPEIIAY-QPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIME-------- 555 Y +P ++ Y K++D WA G + EML G+ F G E E Q I+E Sbjct: 188 KWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEE 247 Query: 556 --------------HNVAYP--------KSMSKEAVAICKGLMTKHPGKRLGCGPEGERD 593 +++ P +S+EAV + ++T P RL + Sbjct: 248 DRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREAVDFLEQILTFSPMDRLTA-----EE 302 Query: 594 IKEHAFFRYIDW 605 H + + Sbjct: 303 ALSHPYMSIYSF 314 >4OW8-A nrPDB Length = 283 Score = 204 bits (518), Expect = 1e-52, Method: Composition-based stats. Identities = 64/260 (24%), Positives = 109/260 (41%), Gaps = 8/260 (3%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 + ++ G G+V + AVK+LK + + +E E R A+ P Sbjct: 13 YRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLN-HP 71 Query: 402 FLTQLHSCFQT-----MDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFF 456 + +H ++ Y VME VNG L +++ GR HA+ + L Sbjct: 72 GIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQI 131 Query: 457 LQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFC-GTPDYIAPEIIAY 515 + G+++RD+K N+++ G +KI DFG+ K VT GT YIAPE Sbjct: 132 AHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQALG 191 Query: 516 QPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDEL-FQSIMEHNVAYPKSMSKEAVAICKG 574 + D ++ GV+ YE ++G+ PF G+ + + I E P + + + Sbjct: 192 HDASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKEPPPPLPPDLPPNVRELIEI 251 Query: 575 LMTKHPGKRLGCGPEGERDI 594 + K+P R G + Sbjct: 252 TLVKNPAMRYRSGGPFADAV 271 >4X3F-A nrPDB Length = 337 Score = 204 bits (518), Expect = 1e-52, Method: Composition-based stats. Identities = 64/260 (24%), Positives = 109/260 (41%), Gaps = 8/260 (3%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 + ++ G G+V + AVK+LK + + +E E R A+ P Sbjct: 14 YRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLN-HP 72 Query: 402 FLTQLHSCFQT-----MDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFF 456 + +H ++ Y VME VNG L +++ GR HA+ + L Sbjct: 73 GIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQI 132 Query: 457 LQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFC-GTPDYIAPEIIAY 515 + G+++RD+K N+++ G +KI DFG+ K VT GT YIAPE Sbjct: 133 AHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQALG 192 Query: 516 QPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDEL-FQSIMEHNVAYPKSMSKEAVAICKG 574 + D ++ GV+ YE ++G+ PF G+ + + I E P + + + Sbjct: 193 HDASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKEPPPPLPPDLPPNVRELIEI 252 Query: 575 LMTKHPGKRLGCGPEGERDI 594 + K+P R G + Sbjct: 253 TLVKNPAMRYRSGGPFADAV 272 >6B2Q-A nrPDB Length = 317 Score = 204 bits (518), Expect = 1e-52, Method: Composition-based stats. Identities = 64/260 (24%), Positives = 109/260 (41%), Gaps = 8/260 (3%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 + ++ G G+V + AVK+LK + + +E E R A+ P Sbjct: 34 YRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLN-HP 92 Query: 402 FLTQLHSCFQT-----MDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFF 456 + +H ++ Y VME VNG L +++ GR HA+ + L Sbjct: 93 GIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQI 152 Query: 457 LQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFC-GTPDYIAPEIIAY 515 + G+++RD+K N+++ G +KI DFG+ K VT GT YIAPE Sbjct: 153 AHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQALG 212 Query: 516 QPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDEL-FQSIMEHNVAYPKSMSKEAVAICKG 574 + D ++ GV+ YE ++G+ PF G+ + + I E P + + + Sbjct: 213 HDASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKEPPPPLPPDLPPNVRELIEI 272 Query: 575 LMTKHPGKRLGCGPEGERDI 594 + K+P R G + Sbjct: 273 TLVKNPAMRYRSGGPFADAV 292 >3PLS-A nrPDB Length = 298 Score = 203 bits (516), Expect = 3e-52, Method: Composition-based stats. Identities = 56/250 (22%), Positives = 102/250 (40%), Gaps = 12/250 (4%) Query: 346 MVLGKGSFGKVMLSERKGTDE---LYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPF 402 V+GKG FG V E + A+K L + +Q VE + E ++ P Sbjct: 27 RVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQ--QVEAFLREGLLMRGLNHPNV 84 Query: 403 LTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR-FKEPHAVFYAAEIAIGLFFLQSKG 461 L + + ++ Y+ GDL+ I+ R + + ++A G+ +L + Sbjct: 85 LALIGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLAEQK 144 Query: 462 IIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTT----KTFCGTPDYIAPEIIAYQP 517 ++RDL N MLD +K+ADFG+ ++ + + + + A E + Sbjct: 145 FVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWTALESLQTYR 204 Query: 518 YGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIMEH-NVAYPKSMSKEAVAICKGL 575 + D W+FGVLL+E+L G P+ D +L + + + P+ + + Sbjct: 205 FTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSLYQVMQQC 264 Query: 576 MTKHPGKRLG 585 P R Sbjct: 265 WEADPAVRPT 274 >3M42-A nrPDB Length = 299 Score = 202 bits (515), Expect = 3e-52, Method: Composition-based stats. Identities = 65/280 (23%), Positives = 106/280 (37%), Gaps = 53/280 (18%) Query: 339 LTDFNFL-MVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALP 397 + D+ VLG G GKV+ K T E +A+K+L D E + Sbjct: 16 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML--------QDCPKARREVELHWRA 67 Query: 398 GKPPFLTQLHSCFQT----MDRLYFVMEYVNGGDLMYHIQQVGR--FKEPHAVFYAAEIA 451 + P + ++ ++ L VME ++GG+L IQ G F E A I Sbjct: 68 SQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIG 127 Query: 452 IGLFFLQSKGIIYRDLKLDNVMLDS---EGHIKIADFGMCKENIWDGVTTKTFCGTPDYI 508 + +L S I +RD+K +N++ S +K+ DFG KE Sbjct: 128 EAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT---------------- 171 Query: 509 APEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDEL----FQSIMEHNVAYP--- 561 + Y KS D W+ GV++Y +L G PF + I +P Sbjct: 172 ------GEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPE 225 Query: 562 -KSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFF 600 +S+E + + L+ P +R+ + H + Sbjct: 226 WSEVSEEVKMLIRNLLKTEPTQRMTIT-----EFMNHPWI 260 >5AP3-A nrPDB Length = 313 Score = 202 bits (513), Expect = 5e-52, Method: Composition-based stats. Identities = 56/280 (20%), Positives = 112/280 (40%), Gaps = 26/280 (9%) Query: 337 MKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLAL 396 +K ++ L +G G KV ++YA+K + + + ++ E L Sbjct: 25 VKGRIYSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEE-ADNQTLDSYRNEIAYLNK 82 Query: 397 PGKP-PFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 455 + + +L+ T +Y VME DL +++ Y + + Sbjct: 83 LQQHSDKIIRLYDYEITDQYIYMVME-CGNIDLNGWLKKKKSIDPWERKSYWKNMLEAVH 141 Query: 456 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWD--GVTTKTFCGTPDYIAPEII 513 + GI++ DLK N ++ +G +K+ DFG+ + D V + GT +Y+ PE I Sbjct: 142 TIHQHGIVHSDLKPANFLIV-DGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAI 200 Query: 514 AYQPYGKS-----------VDWWAFGVLLYEMLAGQAPFEG-EDEDELFQSIME--HNVA 559 + D W+ G +LY M G+ PF+ ++ +I++ H + Sbjct: 201 KDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIE 260 Query: 560 YPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAF 599 +P K+ + K + + P +R+ ++ H + Sbjct: 261 FPDIPEKDLQDVLKCCLKRDPKQRISI-----PELLAHPY 295 >4M7I-A nrPDB Length = 299 Score = 202 bits (513), Expect = 5e-52, Method: Composition-based stats. Identities = 68/297 (22%), Positives = 126/297 (42%), Gaps = 42/297 (14%) Query: 339 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 398 LTDF + LG+G FG V ++ K D YA+K ++ + ++ E M E + LA Sbjct: 4 LTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIR--LPNRELAREKVMREVKALAKLE 61 Query: 399 KPPFLTQLHSCFQTMD-----------RLYFVMEYVNGGDLMYHIQQVGRFKEPH---AV 444 P + ++ + LY M+ +L + +E + Sbjct: 62 HPGIVRYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCL 121 Query: 445 FYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGV-------- 496 +IA + FL SKG+++RDLK N+ + +K+ DFG+ D Sbjct: 122 HIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPM 181 Query: 497 ----TTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQS 552 GT Y++PE I Y VD ++ G++L+E+L PF + E ++ Sbjct: 182 PAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELL---YPF--STQMERVRT 236 Query: 553 IME-HNVAYPKSMSKE---AVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDW 605 + + N+ +P +++ + + +++ P +R +I E+A F +D+ Sbjct: 237 LTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMER-----PEAINIIENAVFEDLDF 288 >4NEU-A nrPDB Length = 333 Score = 202 bits (513), Expect = 6e-52, Method: Composition-based stats. Identities = 67/277 (24%), Positives = 119/277 (42%), Gaps = 23/277 (8%) Query: 329 DNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTM 388 D + N +MK +DF L G FGKV L + + +K + K + + + Sbjct: 13 DMSLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMI-MKTVYKGPNCIEHN--EAL 69 Query: 389 VEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAA 448 +E+ + + + +L + VMEY+ G+LM+ ++ Sbjct: 70 LEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIIL 129 Query: 449 EIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWD-------------G 495 EI G+ +L KG+I++DLK +N+++D++ HIKIAD G+ +W Sbjct: 130 EIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVD 189 Query: 496 VTTKTFCGTPDYIAPEIIAY--QPYGKSVDWWAFGVLLYEMLAGQAPFEG-EDEDELFQS 552 T K GT Y+APE + + D ++F V+L+ + A + P+E E +L Sbjct: 190 GTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMC 249 Query: 553 IMEHNV----AYPKSMSKEAVAICKGLMTKHPGKRLG 585 I N + +E +++ K +P R Sbjct: 250 IKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPT 286 >5WNO-A nrPDB Length = 330 Score = 201 bits (512), Expect = 7e-52, Method: Composition-based stats. Identities = 71/326 (21%), Positives = 129/326 (39%), Gaps = 35/326 (10%) Query: 343 NFLMVLGKGSFGKVMLS-----ERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALP 397 LG G+FG V K A+K+ + D D+ M+E+ Sbjct: 25 KLDKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTDQSQTDE-----MLEEATNMFR 79 Query: 398 GKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQ-QVGRFKEPHAVFYAAEIAIGLFF 456 + L ++ D L V Y G+L ++ V Y +IA G+ + Sbjct: 80 LRHDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKENLGAREQVLYCYQIASGMQY 139 Query: 457 LQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCK--ENIWDGVTTKTFCGTPDYIAPEIIA 514 L+ + +++RDL NV++ H++I DFG+ K ++ D +T K+ ++A EI + Sbjct: 140 LEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIEIFS 199 Query: 515 YQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIMEHN-VAYPKSMSKEAVAIC 572 Y + D WAFGV +E++ GQ+P++G D + + + N ++ P + S++ Sbjct: 200 KHCYTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQPPNCSQDLYQEL 259 Query: 573 KGLMTKHPGKRLG--CGPEGERDIKEHA--FFRYIDWEKLERKEIQPPYKPKARDKRDTS 628 P R G E ++ + F + + D S Sbjct: 260 LRCWMADPKSRPGFEILYERFKEFCKVPQLFLENSNK----------------ISESDLS 303 Query: 629 NFDKEFTRQPVELTPTDKLFIMNLDQ 654 ++ T + E+ + M DQ Sbjct: 304 AEERFQTERIREMFDGNIDPQMYFDQ 329 >4DNL-A nrPDB Length = 140 Score = 201 bits (512), Expect = 7e-52, Method: Composition-based stats. Identities = 105/138 (76%), Positives = 122/138 (88%) Query: 155 HTERRGRIYIQAHIDREVLIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKT 214 HTE+RGRIY++A + E L V VRDAKNL+PMDPNGLSDPYVKLKLIPDPK+ESKQKTKT Sbjct: 2 HTEKRGRIYLKAEVADEKLHVTVRDAKNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKT 61 Query: 215 IKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKAGVDGW 274 I+ +LNP+WNE+F F+LK SDKDRRLSVEIWDWD T+RNDFMGSLSFG+SEL K GW Sbjct: 62 IRSTLNPQWNESFTFKLKPSDKDRRLSVEIWDWDRTTRNDFMGSLSFGVSELMKMPASGW 121 Query: 275 FKLLSQEEGEYFNVPVPP 292 +KLL+QEEGEY+NVP+P Sbjct: 122 YKLLNQEEGEYYNVPIPE 139 >3ZZW-A nrPDB Length = 289 Score = 201 bits (512), Expect = 8e-52, Method: Composition-based stats. Identities = 58/277 (20%), Positives = 106/277 (38%), Gaps = 28/277 (10%) Query: 332 GNRDRMKLTDFNFLMVLGKGSFGKVMLSERKG-----TDELYAVKILKKDVVIQDDDVEC 386 G + L+ F+ LG+ FGKV G + A+K LK + + Sbjct: 1 GKLKEISLSAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKA---EGPLRE 57 Query: 387 TMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR--------- 437 + +L + P + L L + Y + GDL + Sbjct: 58 EFRHEAMLRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDD 117 Query: 438 -------FKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKE 490 + P V A+IA G+ +L S ++++DL NV++ + ++KI+D G+ +E Sbjct: 118 DRTVKSALEPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFRE 177 Query: 491 NIWDGVTTKTFCG--TPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDED 547 ++APE I Y + D W++GV+L+E+ + G P+ G Sbjct: 178 VYAADYYKLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQ 237 Query: 548 ELFQSIMEHN-VAYPKSMSKEAVAICKGLMTKHPGKR 583 ++ + I + P A+ + P +R Sbjct: 238 DVVEMIRNRQVLPCPDDCPAWVYALMIECWNEFPSRR 274 >5Y86-A nrPDB Length = 588 Score = 201 bits (511), Expect = 8e-52, Method: Composition-based stats. Identities = 65/245 (26%), Positives = 101/245 (41%), Gaps = 20/245 (8%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 + L ++GKGSFG+V + A+K+++ + E E R+L K Sbjct: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAE----EIRILEHLKKQD 264 Query: 402 -----FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR--FKEPHAVFYAAEIAIGL 454 + + F + + E ++ DL I++ F +A I L Sbjct: 265 KTGSMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQGFSVQLVRKFAQSILQSL 323 Query: 455 FFLQSKGIIYRDLKLDNVMLDSEGH--IKIADFGMCKENIWDGVTTKTFCGTPDYIAPEI 512 L II+ DLK +N++L G K+ DFG ++ T+ + Y APEI Sbjct: 324 DALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSS---CFEYQKLYTYIQSRFYRAPEI 380 Query: 513 IAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSM---SKEAV 569 I Y +D W+FG +L E+L GQ F GEDE + +ME P + SK A Sbjct: 381 ILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAK 440 Query: 570 AICKG 574 Sbjct: 441 YFINS 445 >4HVI-A nrPDB Length = 314 Score = 199 bits (505), Expect = 4e-51, Method: Composition-based stats. Identities = 67/284 (23%), Positives = 111/284 (39%), Gaps = 38/284 (13%) Query: 337 MKLTDFNFLMVLGKGSFGKVMLSERK----GTDELYAVKILKKDVVIQDDDVECTMVEKR 392 + ++ LGKG+FG V L T L AVK L+ D E + Sbjct: 7 FEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSG---PDQQRDFQREIQ 63 Query: 393 VLALPGKPPFLTQLHSCFQTMDR--LYFVMEYVNGGDLMYHIQQVG-RFKEPHAVFYAAE 449 +L F+ + R L VMEY+ G L +Q+ R + Y+++ Sbjct: 64 ILKAL-HSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQ 122 Query: 450 IAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCK--ENIWDGVTTKTFCGTP-D 506 I G+ +L S+ ++RDL N++++SE H+KIADFG+ K D + +P Sbjct: 123 ICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIF 182 Query: 507 YIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGED---EDELFQSIME-------- 555 + APE ++ + + D W+FGV+LYE+ + + E + + Sbjct: 183 WYAPESLSDNIFSRQSDVWSFGVVLYELFT----YCDKSCSPSAEFLRMMGSERDVPALS 238 Query: 556 ---------HNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEG 590 + P + E + K P R G Sbjct: 239 RLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALG 282 >5X8I-B nrPDB Length = 346 Score = 198 bits (504), Expect = 5e-51, Method: Composition-based stats. Identities = 67/326 (20%), Positives = 107/326 (32%), Gaps = 76/326 (23%) Query: 342 FNFLMVLGKGSFGKVMLSE-RKGTDELYAVKILKK-DVVIQDDDVECTMVEKRVLALPGK 399 + + LG+G+FGKV+ K AVKI+K D + E ++E P Sbjct: 15 YEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNS 74 Query: 400 PPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVG--RFKEPHAVFYAAEIAIGLFFL 457 Q+ F+ + V E + G I++ G F+ H A +I + FL Sbjct: 75 TFRCVQMLEWFEHHGHICIVFELL-GLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFL 133 Query: 458 QSKGIIYRDLKLDNVMLDS-------------------EGHIKIADFGMCKENIWDGVTT 498 S + + DLK +N++ IK+ DFG +D Sbjct: 134 HSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSA---TYDDEHH 190 Query: 499 KTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNV 558 T T Y APE+I + + D W+ G +L E G F D E + Sbjct: 191 STLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILG 250 Query: 559 AYPKSMSKEAV--------------------------------------------AICKG 574 PK M ++ + + Sbjct: 251 PLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQDVEHERLFDLIQK 310 Query: 575 LMTKHPGKRLGCGPEGERDIKEHAFF 600 ++ P KR+ R+ +H FF Sbjct: 311 MLEYDPAKRITL-----REALKHPFF 331 >2UZP-A nrPDB Length = 144 Score = 198 bits (504), Expect = 6e-51, Method: Composition-based stats. Identities = 93/137 (67%), Positives = 115/137 (83%), Gaps = 1/137 (0%) Query: 155 HTERRGRIYIQAHI-DREVLIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTK 213 HTERRGR+ ++ + + V V +A+NL+PMDPNGLSDPYVKLKLIPDP++ +KQKT+ Sbjct: 3 HTERRGRLQLEIRAPTADEIHVTVGEARNLIPMDPNGLSDPYVKLKLIPDPRNLTKQKTR 62 Query: 214 TIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKAGVDG 273 T+K +LNP WNETF F LK D +RRLSVE+WDWD TSRNDFMG++SFG+SEL KA VDG Sbjct: 63 TVKATLNPVWNETFVFNLKPGDVERRLSVEVWDWDRTSRNDFMGAMSFGVSELLKAPVDG 122 Query: 274 WFKLLSQEEGEYFNVPV 290 W+KLL+QEEGEY+NVPV Sbjct: 123 WYKLLNQEEGEYYNVPV 139 >4E20-A nrPDB Length = 290 Score = 198 bits (503), Expect = 8e-51, Method: Composition-based stats. Identities = 61/275 (22%), Positives = 99/275 (36%), Gaps = 41/275 (14%) Query: 342 FNFLMVLGKGSFGKV----MLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALP 397 + LG+G FGKV GT E+ AVK LK+ Q E +L Sbjct: 10 LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSGWQ--REIEILRTL 67 Query: 398 GKPPFLTQLHSCFQTMDR--LYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 455 + + C + + VMEYV G L ++ + + +A +I G+ Sbjct: 68 -YHEHIVKYKGCCEDQGEKSVQLVMEYVPLGSLRDYLPRHC-VGLAQLLLFAQQICEGMA 125 Query: 456 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTK---TFCGTPDYIAPEI 512 +L ++ I+R L NV+LD++ +KI DFG+ K + + APE Sbjct: 126 YLHAQHYIHRALAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPEC 185 Query: 513 IAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDED----------------------ELF 550 + + + D W+FGV LYE+L + ++ EL Sbjct: 186 LKECKFYYASDVWSFGVTLYELLT----YCDSNQSPHTKFTELIGHTQGQMTVLRLTELL 241 Query: 551 QSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLG 585 + + P E + K R Sbjct: 242 ER--GERLPRPDRCPCEIYHLMKNCWETEASFRPT 274 >6DBN-A nrPDB Length = 316 Score = 197 bits (501), Expect = 1e-50, Method: Composition-based stats. Identities = 62/273 (22%), Positives = 106/273 (38%), Gaps = 35/273 (12%) Query: 342 FNFLMVLGKGSFGKVMLSERK----GTDELYAVKILKKDVVIQDDDVECTMVEKRVLALP 397 + LG+G FGKV L T E AVK LK + + + E +L Sbjct: 37 LKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGG--NHIADLKKEIEILRNL 94 Query: 398 GKPPFLTQLHSCFQTMDR-LYFVMEYVNGGDLMYHI-QQVGRFKEPHAVFYAAEIAIGLF 455 + C + + +ME++ G L ++ + + + YA +I G+ Sbjct: 95 YHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMD 154 Query: 456 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGM--CKENIWDGVTTKTFCGTP-DYIAPEI 512 +L S+ ++RDL NV+++SE +KI DFG+ E + T K +P + APE Sbjct: 155 YLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPEC 214 Query: 513 IAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDED-------------------ELFQSI 553 + + + D W+FGV L+E+L + D L ++ Sbjct: 215 LMQSKFYIASDVWSFGVTLHELLT----YCDSDSSPMALFLKMIGPTHGQMTVTRLVNTL 270 Query: 554 MEHN-VAYPKSMSKEAVAICKGLMTKHPGKRLG 585 E + P + E + + P R Sbjct: 271 KEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTS 303 >3N9X-A nrPDB Length = 432 Score = 197 bits (500), Expect = 2e-50, Method: Composition-based stats. Identities = 72/377 (19%), Positives = 136/377 (36%), Gaps = 98/377 (25%) Query: 331 NGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVE 390 G ++ ++ ++G+GS+G V L+ K T++ A+K + + + D + + E Sbjct: 17 QGIKNVHVPDNYIIKHLIGRGSYGYVYLAYDKNTEKNVAIKKVNR-MFEDLIDCKRILRE 75 Query: 391 KRVLALPGKPPFLTQLHSCFQTMD-----RLYFVMEYVNGGDLMYHIQQVGRFKEPHAVF 445 +L K ++ +L+ D LY V+E + DL + E H Sbjct: 76 ITILNRL-KSDYIIRLYDLIIPDDLLKFDELYIVLEIAD-SDLKKLFKTPIFLTEEHIKT 133 Query: 446 YAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVT-------- 497 + +G F+ GII+RDLK N +L+ + +K+ DFG+ + + T Sbjct: 134 ILYNLLLGENFIHESGIIHRDLKPANCLLNQDCSVKVCDFGLARTINSEKDTNIVNDLEE 193 Query: 498 --------------TKTFCGTPDYIAPE-IIAYQPYGKSVDWWAFGVLLYEML------- 535 + T Y APE I+ + Y KS+D W+ G + E+L Sbjct: 194 NEEPGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAELLNMLQSHI 253 Query: 536 ----AGQAPFEGE-----------------------------------------DEDELF 550 F G ++ E+ Sbjct: 254 NDPTNRFPLFPGSSCFPLSPDRNSKKVHEKSNRDQLNIIFNIIGTPTEDDLKNINKPEVI 313 Query: 551 QSIMEHNVAYP-------KSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYI 603 + I P S+S + + + + ++ +P KR+ +H + + + Sbjct: 314 KYIKLFPHRKPINLKQKYPSISDDGINLLESMLKFNPNKRITI-----DQALDHPYLKDV 368 Query: 604 DWEKLER---KEIQPPY 617 +KLE K+I P+ Sbjct: 369 RKKKLENFSTKKIILPF 385 >3PG1-A nrPDB Length = 362 Score = 196 bits (499), Expect = 2e-50, Method: Composition-based stats. Identities = 60/309 (19%), Positives = 106/309 (34%), Gaps = 56/309 (18%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKK--------DVVIQDDDVECTMVEKRV 393 + + GS+G V A+K + +++ + + E R+ Sbjct: 24 YTVQRFISSGSYGAVCAGVDSE-GIPVAIKRVFNTVSDGRTVNILSDSFLCKRVLREIRL 82 Query: 394 LALPGKPPFLTQLHSCFQT-----MDRLYFVMEYVNGGDLMYHIQ-QVGRFKEPHAVFYA 447 L P + L F M +LY V E + DL I Q H ++ Sbjct: 83 LNHF-HHPNILGLRDIFVHFEEPAMHKLYLVTELMRT-DLAQVIHDQRIVISPQHIQYFM 140 Query: 448 AEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDY 507 I +GL L G+++RDL N++L I I DF + +E+ D T + Y Sbjct: 141 YHILLGLHVLHEAGVVHRDLHPGNILLADNNDITICDFNLAREDTADANKTH-YVTHRWY 199 Query: 508 IAPE-IIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIME--HNVAYPKSM 564 APE ++ ++ + K VD W+ G ++ EM +A F G I+E + Sbjct: 200 RAPELVMQFKGFTKLVDMWSAGCVMAEMFNRKALFRGSTFYNQLNKIVEVVGTPKIEDVV 259 Query: 565 ------------------------------SKEAVAICKGLMTKHPGKRLGCGPEGERDI 594 A+ + ++ +P +R+ Sbjct: 260 MFSSPSARDYLRNSLSNVPARAWTAVVPTADPVALDLIAKMLEFNPQRRIST-----EQA 314 Query: 595 KEHAFFRYI 603 H +F + Sbjct: 315 LRHPYFESL 323 >3NIE-A nrPDB Length = 429 Score = 196 bits (499), Expect = 2e-50, Method: Composition-based stats. Identities = 70/371 (18%), Positives = 126/371 (33%), Gaps = 101/371 (27%) Query: 340 TDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK 399 ++ ++G+GS+G V L+ K ++ A+K + + + D + + E +L K Sbjct: 28 DNYEIKHLIGRGSYGYVYLAYDKNANKNVAIKKVNR-MFEDLIDCKRILREITILNRL-K 85 Query: 400 PPFLTQLHSCFQTMD-----RLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGL 454 ++ +LH D LY V+E + DL + E H + +G Sbjct: 86 SDYIIRLHDLIIPEDLLKFDELYIVLEIAD-SDLKKLFKTPIFLTEQHVKTILYNLLLGE 144 Query: 455 FFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGV------------------ 496 F+ GII+RDLK N +L+ + +KI DFG+ + D Sbjct: 145 KFIHESGIIHRDLKPANCLLNQDCSVKICDFGLARTINSDKDIHIVNDLEEKEENEEPGP 204 Query: 497 -------TTKTFCGTPDYIAPE-IIAYQPYGKSVDWWAFGVLLYEML-----------AG 537 + T Y APE I+ + Y S+D W+ G + E+L Sbjct: 205 HNKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDIWSTGCIFAELLNMMKSHINNPTNR 264 Query: 538 QAPFEG-----------------EDEDELFQSIMEHNVAYPK------------------ 562 F G + + I P+ Sbjct: 265 FPLFPGSSCFPLSPDHNSKKVHEKSNRDQLNIIFNVIGTPPEEDLKCITKQEVIKYIKLF 324 Query: 563 -------------SMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLE 609 S+SKE + + + ++ + KR+ H + + + E LE Sbjct: 325 PTRDGIDLSKKYSSISKEGIDLLESMLRFNAQKRITIDK-----ALSHPYLKDVRKENLE 379 Query: 610 R---KEIQPPY 617 ++I P+ Sbjct: 380 NFSTEKIILPF 390 >5ZTN-A nrPDB Length = 429 Score = 196 bits (498), Expect = 3e-50, Method: Composition-based stats. Identities = 61/243 (25%), Positives = 103/243 (42%), Gaps = 16/243 (6%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 + L V+GKGSFG+V+ + + A+K+++ + E + + L K Sbjct: 99 YEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEH-LRKQDKDN 157 Query: 402 --FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR--FKEPHAVFYAAEIAIGLFFL 457 + + F + + E ++ +L I++ F P +A I L L Sbjct: 158 TMNVIHMLENFTFRNHICMTFELLSM-NLYELIKKNKFQGFSLPLVRKFAHSILQCLDAL 216 Query: 458 QSKGIIYRDLKLDNVMLDSEGH--IKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAY 515 II+ DLK +N++L +G IK+ DFG ++ T+ + Y APE+I Sbjct: 217 HKNRIIHCDLKPENILLKQQGRSGIKVIDFGSS---CYEHQRVYTYIQSRFYRAPEVILG 273 Query: 516 QPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPK----SMSKEAVAI 571 YG +D W+ G +L E+L G GEDE + ++E + P SK A Sbjct: 274 ARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIEL-LGMPSQKLLDASKRAKNF 332 Query: 572 CKG 574 Sbjct: 333 VSS 335 >4FL3-A nrPDB Length = 635 Score = 195 bits (497), Expect = 3e-50, Method: Composition-based stats. Identities = 61/259 (23%), Positives = 109/259 (42%), Gaps = 12/259 (4%) Query: 333 NRDRMKLTDFNFLMVLGKGSFGKVMLSERK-GTDELYAVKILKKDVVIQDDDVECTMVEK 391 +R + L D LG G+FG V + + K+ + + E Sbjct: 366 DRKLLTLED----KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEA 421 Query: 392 RVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIA 451 V+ P++ ++ + + VME G L ++QQ K+ + + +++ Sbjct: 422 NVMQQLDN-PYIVRMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVS 479 Query: 452 IGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTK--TFCGTP-DYI 508 +G+ +L+ ++RDL NV+L ++ + KI+DFG+ K D K T P + Sbjct: 480 MGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY 539 Query: 509 APEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIMEHN-VAYPKSMSK 566 APE I Y + D W+FGVL++E + GQ P+ G E+ + + + P + Sbjct: 540 APECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPR 599 Query: 567 EAVAICKGLMTKHPGKRLG 585 E + T R G Sbjct: 600 EMYDLMNLCWTYDVENRPG 618 >5HVK-A nrPDB Length = 315 Score = 195 bits (495), Expect = 7e-50, Method: Composition-based stats. Identities = 61/267 (22%), Positives = 111/267 (41%), Gaps = 22/267 (8%) Query: 337 MKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLAL 396 + +D VLGKG FG+ + + T E+ +K L + ++ + E +V+ Sbjct: 11 FRPSDLIHGEVLGKGCFGQAIKVTHRETGEVMVMKEL---IRFDEETQRTFLKEVKVM-R 66 Query: 397 PGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVG-RFKEPHAVFYAAEIAIGLF 455 + P + + RL F+ EY+ GG L I+ + ++ V +A +IA G+ Sbjct: 67 CLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMA 126 Query: 456 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIW--------------DGVTTKTF 501 +L S II+R+L N ++ ++ +ADFG+ + + D T Sbjct: 127 YLHSMNIIHRNLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTV 186 Query: 502 CGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAG---QAPFEGEDEDELFQSIMEHNV 558 G P ++APE+I + Y + VD ++FG++L E++ + D + Sbjct: 187 VGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDR 246 Query: 559 AYPKSMSKEAVAICKGLMTKHPGKRLG 585 P + I P KR Sbjct: 247 YCPPNCPPSFFPITVRCCDLDPEKRPS 273 >5C26-A nrPDB Length = 299 Score = 195 bits (495), Expect = 7e-50, Method: Composition-based stats. Identities = 61/259 (23%), Positives = 109/259 (42%), Gaps = 12/259 (4%) Query: 333 NRDRMKLTDFNFLMVLGKGSFGKVMLSERK-GTDELYAVKILKKDVVIQDDDVECTMVEK 391 +R + L D LG G+FG V + + K+ + + E Sbjct: 24 DRKLLTLED----KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEA 79 Query: 392 RVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIA 451 V+ P++ ++ + + VME G L ++QQ K+ + + +++ Sbjct: 80 NVMQQLDN-PYIVRMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVS 137 Query: 452 IGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTK--TFCGTP-DYI 508 +G+ +L+ ++RDL NV+L ++ + KI+DFG+ K D K T P + Sbjct: 138 MGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY 197 Query: 509 APEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIMEHN-VAYPKSMSK 566 APE I Y + D W+FGVL++E + GQ P+ G E+ + + + P + Sbjct: 198 APECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPR 257 Query: 567 EAVAICKGLMTKHPGKRLG 585 E + T R G Sbjct: 258 EMYDLMNLCWTYDVENRPG 276 >2WO6-A nrPDB Length = 382 Score = 195 bits (495), Expect = 7e-50, Method: Composition-based stats. Identities = 62/254 (24%), Positives = 109/254 (42%), Gaps = 20/254 (7%) Query: 339 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 398 + + ++GKGSFG+V+ + + E A+KI+K + + +E R+L L Sbjct: 53 MDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKN----KKAFLNQAQIEVRLLELMN 108 Query: 399 KPP-----FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR--FKEPHAVFYAAEIA 451 K ++ L F + L V E ++ +L ++ +A ++ Sbjct: 109 KHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSY-NLYDLLRNTNFRGVSLNLTRKFAQQMC 167 Query: 452 IGLFFLQ--SKGIIYRDLKLDNVMLDSEGH--IKIADFGMCKENIWDGVTTKTFCGTPDY 507 L FL II+ DLK +N++L + IKI DFG + G + + Y Sbjct: 168 TALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQL---GQRIYQYIQSRFY 224 Query: 508 IAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKE 567 +PE++ PY ++D W+ G +L EM G+ F G +E + I+E P + + Sbjct: 225 RSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQ 284 Query: 568 AVAICKGLMTKHPG 581 A + K P Sbjct: 285 APK-ARKFFEKLPD 297 Score = 33.0 bits (74), Expect = 0.39, Method: Composition-based stats. Identities = 5/34 (14%), Positives = 12/34 (35%), Gaps = 5/34 (14%) Query: 569 VAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRY 602 + ++ P R+ +H+FF+ Sbjct: 350 KDLILRMLDYDPKTRIQPYY-----ALQHSFFKK 378 >3E3P-A nrPDB Length = 360 Score = 194 bits (494), Expect = 8e-50, Method: Composition-based stats. Identities = 69/328 (21%), Positives = 125/328 (38%), Gaps = 57/328 (17%) Query: 319 EKTANTISKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVV 378 + +++ R R ++ F + G+G+FG V L + K T A+K + +D Sbjct: 2 PGSMMSLNAAAAADERSRKEMDRFQVERMAGQGTFGTVQLGKEKSTGMSVAIKKVIQDPR 61 Query: 379 IQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDR-------LYFVMEYVN---GGDL 428 ++ +++ M + VL P + QL S F T+ L VMEYV Sbjct: 62 FRNRELQ-IMQDLAVL----HHPNIVQLQSYFYTLGERDRRDIYLNVVMEYVPDTLHRCC 116 Query: 429 MYHIQQVGRFKEPHAVFYAAEIAI--GLFFLQSKGIIYRDLKLDNVMLDS-EGHIKIADF 485 + ++ + ++ G L S + +RD+K NV+++ +G +K+ DF Sbjct: 117 RNYYRRQVAPPPILIKVFLFQLIRSIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDF 176 Query: 486 GMCKENIWDGVTTKTFCGTPDYIAPEIIAY-QPYGKSVDWWAFGVLLYEMLAGQAPFEGE 544 G K+ C + Y APE+I Q Y +VD W+ G + EM+ G+ F G+ Sbjct: 177 GSAKKLSPSEPNVAYIC-SRYYRAPELIFGNQHYTTAVDIWSVGCIFAEMMLGEPIFRGD 235 Query: 545 DEDELFQSIMEHNVAYPKSM--------------------------------SKEAVAIC 572 + I+ + + +KEA + Sbjct: 236 NSAGQLHEIVRVLGCPSREVLRKLNPSHTDVDLYNSKGIPWSNVFSDHSLKDAKEAYDLL 295 Query: 573 KGLMTKHPGKRLGCGPEGERDIKEHAFF 600 L+ P +R+ + H +F Sbjct: 296 SALLQYLPEERM-----KPYEALCHPYF 318 >5VD3-A nrPDB Length = 311 Score = 194 bits (493), Expect = 1e-49, Method: Composition-based stats. Identities = 65/282 (23%), Positives = 106/282 (37%), Gaps = 8/282 (2%) Query: 319 EKTANTISKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVV 378 E + S + + F L LG GS+G+V K LYAVK Sbjct: 36 EASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKR-SMSPF 94 Query: 379 IQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVG-R 437 D + E G+ P +L ++ LY E G L H + G Sbjct: 95 RGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELC-GPSLQQHCEAWGAS 153 Query: 438 FKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVT 497 E Y + + L L S+G+++ D+K N+ L G K+ DFG+ E G Sbjct: 154 LPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGA- 212 Query: 498 TKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAG-QAPFEGEDEDELFQSIMEH 556 + G P Y+APE++ YG + D ++ G+ + E+ + P GE +L Q + Sbjct: 213 GEVQEGDPRYMAPELLQGS-YGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYL-- 269 Query: 557 NVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHA 598 + +S E ++ ++ P R + Sbjct: 270 PPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQP 311 >6CTH-A nrPDB Length = 309 Score = 194 bits (492), Expect = 1e-49, Method: Composition-based stats. Identities = 53/204 (25%), Positives = 94/204 (46%), Gaps = 9/204 (4%) Query: 340 TDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK 399 ++FN LG+G FG V + +D AVK + + ++ E ++++ + Sbjct: 15 SNFNAENKLGEGGFGSVYRGFLRDSDTYIAVKKVSR---ASKQGIKEYASEVKIISRL-R 70 Query: 400 PPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVF-YAAEIAIGLFFLQ 458 L +L L V E++ G L HI + + ++A L +L Sbjct: 71 HKNLVKLIGWCHERGELMLVYEFMANGSLDSHIFKGKSLLTWEVRYRIVKDLASALLYLH 130 Query: 459 SKG---IIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTF-CGTPDYIAPEIIA 514 +G +++RD+K N+MLDS + K+ DFG+ + KT GT Y+APE ++ Sbjct: 131 EEGDHCVLHRDIKTSNIMLDSSFNAKLGDFGLARLVDHAKGLKKTLLAGTVGYMAPECLS 190 Query: 515 YQPYGKSVDWWAFGVLLYEMLAGQ 538 K D ++FGV+ E+ +G+ Sbjct: 191 SGKASKESDVYSFGVVALEIASGR 214 >5O0Y-A nrPDB Length = 579 Score = 194 bits (492), Expect = 2e-49, Method: Composition-based stats. Identities = 69/276 (25%), Positives = 108/276 (39%), Gaps = 33/276 (11%) Query: 353 FGKVMLSERKGTDELYAVKI--LKKDVVIQDDD--VECTMVEKRVLALPGKPPFLTQLHS 408 F +V + AVKI L K+ + + + E R+ P + +L+ Sbjct: 297 FSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRI-HKELDHPRIVKLYD 355 Query: 409 CFQ-TMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQS--KGIIYR 465 F D V+EY G DL ++++Q E A +I L +L II+ Sbjct: 356 YFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHY 415 Query: 466 DLKLDNVML---DSEGHIKIADFGMCKENIWDGVT-------TKTFCGTPDYIAPEIIAY 515 DLK N++L + G IKI DFG+ K D T GT Y+ PE Sbjct: 416 DLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVV 475 Query: 516 Q----PYGKSVDWWAFGVLLYEMLAGQAPF-EGEDEDELFQ---SIMEHNVAYPKS--MS 565 VD W+ GV+ Y+ L G+ PF + + ++ Q + V +P ++ Sbjct: 476 GKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVT 535 Query: 566 KEAVAICKGLMTKHPGKR-----LGCGPEGERDIKE 596 EA A + + R L C P I++ Sbjct: 536 PEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHIRK 571 >4G3E-A nrPDB Length = 352 Score = 193 bits (491), Expect = 2e-49, Method: Composition-based stats. Identities = 69/275 (25%), Positives = 115/275 (41%), Gaps = 30/275 (10%) Query: 288 VPVPPEGSEGNEELRQKFERAKIGQGTKAPEEKTANT----ISKFDNNGN--RDRMKLTD 341 VPV + + + K +A DN G +++K D Sbjct: 7 VPVEEYLVHALQGSVSSGQAHSLASLAKTWSSGSAKLQRLGPETEDNEGVLLTEKLKPVD 66 Query: 342 FNFLMVL---------GKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKR 392 + + + G+GSFG+V + K T AVK ++ +E VE+ Sbjct: 67 YEYREEVHWMTHQPRVGRGSFGEVHRMKDKQTGFQCAVKKVR---------LEVFRVEEL 117 Query: 393 VLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAI 452 V P + L+ + + ME + GG L I+Q+G E A++Y + Sbjct: 118 VACAGLSSPRIVPLYGAVREGPWVNIFMELLEGGSLGQLIKQMGCLPEDRALYYLGQALE 177 Query: 453 GLFFLQSKGIIYRDLKLDNVMLDSEG-HIKIADFGMCKENIWDG-----VTTKTFCGTPD 506 GL +L ++ I++ D+K DNV+L S+G + DFG DG +T GT Sbjct: 178 GLEYLHTRRILHGDVKADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPGTET 237 Query: 507 YIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPF 541 ++APE++ +P VD W+ ++ ML G P+ Sbjct: 238 HMAPEVVMGKPCDAKVDIWSSCCMMLHMLNGCHPW 272 >4C59-A nrPDB Length = 340 Score = 193 bits (490), Expect = 2e-49, Method: Composition-based stats. Identities = 63/321 (19%), Positives = 118/321 (36%), Gaps = 39/321 (12%) Query: 314 TKAPEEKTANTISKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKIL 373 + A+ + D G + VL +G F V ++ G+ YA+K L Sbjct: 1 SMPGSLGGASGRDQSDFVGQTVELGELRLRVRRVLAEGGFAFVYEAQDVGSGREYALKRL 60 Query: 374 KKDVVIQDDDVECTMVEKRVLALPGKPPFLTQL--------HSCFQTMDRLYFVMEYVNG 425 + +++ + E + P + Q + E Sbjct: 61 ---LSNEEEKNRAIIQEVCFMKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELC-K 116 Query: 426 GDLMYHIQQ---VGRFKEPHAVFYAAEIAIGLFFLQSKG--IIYRDLKLDNVMLDSEGHI 480 G L+ +++ G + + + + + II+RDLK++N++L ++G I Sbjct: 117 GQLVEFLKKMESRGPLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTI 176 Query: 481 KIADFGMCKENIWDGVTTK------------TFCGTPDYIAPEII---AYQPYGKSVDWW 525 K+ DFG + T TP Y PEII + P G+ D W Sbjct: 177 KLCDFGSATTISHYPDYSWSAQRRALVEEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIW 236 Query: 526 AFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSK--EAVAICKGLMTKHPGKR 583 A G +LY + Q PFE + I+ + P ++ ++ + ++ +P +R Sbjct: 237 ALGCILYLLCFRQHPFEDGAKL----RIVNGKYSIPPHDTQYTVFHSLIRAMLQVNPEER 292 Query: 584 LGCGPEGERDIKEHAFFRYID 604 L E ++E A R ++ Sbjct: 293 LSIA-EVVHQLQEIAAARNVN 312 >3QA8-A nrPDB Length = 676 Score = 193 bits (490), Expect = 2e-49, Method: Composition-based stats. Identities = 60/211 (28%), Positives = 96/211 (45%), Gaps = 16/211 (7%) Query: 343 NFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPF 402 LG G FG V+ + T E A+K ++++ ++ + C +E +++ P Sbjct: 17 EMKERLGTGGFGYVLRWIHQDTGEQVAIKQCRQELSPKNRERWC--LEIQIMKKLN-HPN 73 Query: 403 LTQLHSCFQTMDRL------YFVMEYVNGGDLMYHIQQVGR---FKEPHAVFYAAEIAIG 453 + + +L MEY GGDL ++ Q KE ++I+ Sbjct: 74 VVSAREVPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGPIRTLLSDISSA 133 Query: 454 LFFLQSKGIIYRDLKLDNVMLD---SEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAP 510 L +L II+RDLK +N++L KI D G KE G F GT Y+AP Sbjct: 134 LRYLHENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKEL-DQGELCTEFVGTLQYLAP 192 Query: 511 EIIAYQPYGKSVDWWAFGVLLYEMLAGQAPF 541 E++ + Y +VD+W+FG L +E + G PF Sbjct: 193 ELLEQKKYTVTVDYWSFGTLAFECITGFRPF 223 >4TPT-A nrPDB Length = 303 Score = 192 bits (489), Expect = 3e-49, Method: Composition-based stats. Identities = 58/267 (21%), Positives = 108/267 (40%), Gaps = 29/267 (10%) Query: 341 DFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKP 400 D VLGKG FG+ + K T ++ +K L + ++ + + E +V+ Sbjct: 1 DLIHGEVLGKGFFGQAIKVTHKATGKVMVMKEL---IRCDEETQKTFLTEVKVMRSLD-H 56 Query: 401 PFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSK 460 P + + +L + EY+ GG L ++ + F V +A IA G+ +L S Sbjct: 57 PNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMAYLHSM 116 Query: 461 GIIYRDLKLDNVMLDSEGHIKIADFGMCKENIW--------------------DGVTTKT 500 II+RDL N ++ + + +ADFG+ + + D T Sbjct: 117 CIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYT 176 Query: 501 FCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNV-- 558 G P ++APE++ + Y ++VD ++FG++L E++ GQ + + + + Sbjct: 177 VVGNPYWMAPEMLNGKSYDETVDIFSFGIVLCEII-GQVYADPDCLPRTLDFGLNVKLFW 235 Query: 559 --AYPKSMSKEAVAICKGLMTKHPGKR 583 P + P R Sbjct: 236 EKFVPTDCPPAFFPLAAICCRLEPESR 262 >6FYV-A nrPDB Length = 337 Score = 192 bits (487), Expect = 6e-49, Method: Composition-based stats. Identities = 63/330 (19%), Positives = 105/330 (31%), Gaps = 84/330 (25%) Query: 342 FNFLMVLGKGSFGKVMLSERKG-TDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG-- 398 + + LG+G+FGKV+ G AVKI+K + E E +VL Sbjct: 16 YEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYR----EAARSEIQVLEHLNST 71 Query: 399 KPPFL---TQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVG--RFKEPHAVFYAAEIAIG 453 P + Q+ F + V E + G I++ F+ H A +I Sbjct: 72 DPNSVFRCVQMLEWFDHHGHVCIVFELL-GLSTYDFIKENSFLPFQIDHIRQMAYQICQS 130 Query: 454 LFFLQSKGIIYRDLKLDNVMLDS-------------------EGHIKIADFGMCKENIWD 494 + FL + + DLK +N++ IK+ DFG +D Sbjct: 131 INFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSA---TYD 187 Query: 495 GVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIM 554 T T Y APE+I + + D W+ G +L E G F+ D E + Sbjct: 188 DEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMME 247 Query: 555 EHNVAYPKSM--------------------------------------------SKEAVA 570 P+ M ++ Sbjct: 248 RILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFD 307 Query: 571 ICKGLMTKHPGKRLGCGPEGERDIKEHAFF 600 + + ++ P +R+ + +H FF Sbjct: 308 LVRRMLEYDPTQRITL-----DEALQHPFF 332 >4F0G-A nrPDB Length = 287 Score = 192 bits (487), Expect = 6e-49, Method: Composition-based stats. Identities = 57/262 (21%), Positives = 111/262 (42%), Gaps = 24/262 (9%) Query: 340 TDFNFLMVLGKGSFGKVMLSERKGTDELYAVKIL----KKDVVIQDDDVECTMVEKRVLA 395 + + +GKG FG V + A+K L + + + E +++ Sbjct: 19 NEIEYEKQIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQREVFIMS 78 Query: 396 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYH-IQQVGRFKEPHAVFYAAEIAIGL 454 P + +L+ R VME+V GDL + + + K + +IA+G+ Sbjct: 79 -NLNHPNIVKLYGLMHNPPR--MVMEFVPCGDLYHRLLDKAHPIKWSVKLRLMLDIALGI 135 Query: 455 FFLQSKG--IIYRDLKLDNVM---LDSEGHI--KIADFGMCKENIWDGVTTKTFCGTPDY 507 ++Q++ I++RDL+ N+ LD + K+ADFG+ ++++ G + Sbjct: 136 EYMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQSVHS---VSGLLGNFQW 192 Query: 508 IAPEII--AYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDEL--FQSIMEH--NVAYP 561 +APE I + Y + D ++F ++LY +L G+ PF+ ++ I E P Sbjct: 193 MAPETIGAEEESYTEKADTYSFAMILYTILTGEGPFDEYSYGKIKFINMIREEGLRPTIP 252 Query: 562 KSMSKEAVAICKGLMTKHPGKR 583 + + + + P KR Sbjct: 253 EDCPPRLRNVIELCWSGDPKKR 274 >4Y83-A nrPDB Length = 332 Score = 191 bits (486), Expect = 6e-49, Method: Composition-based stats. Identities = 57/257 (22%), Positives = 107/257 (41%), Gaps = 24/257 (9%) Query: 350 KGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSC 409 +G+FGKV L++ T + A K++ D + DVE + + + +L+ Sbjct: 83 RGAFGKVYLAQDIKTKKRMACKLIPVDQ-FKPSDVE--------IQACFRHENIAELYGA 133 Query: 410 FQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKL 469 + ++ ME GG ++ ++ G +E ++ + GL FL SK +I+ D+K Sbjct: 134 VLWGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHHDIKP 193 Query: 470 DNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGV 529 N++ S + + DFG+ + D K GT Y++PE+I + + D ++ G Sbjct: 194 SNIVFMSTKAV-LVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILCRGHSTKADIYSLGA 252 Query: 530 LLYEMLAGQAPF---EGEDEDELFQSIMEHNVAYP-----KSMSKEAVAICKGLMTKHPG 581 L M G P+ + I+ H A P S + + + ++P Sbjct: 253 TLIHMQTGTPPWVKRYPRSAYPSYLYII-HKQAPPLEDIADDCSPGMRELIEASLERNPN 311 Query: 582 KRLGCGPEGERDIKEHA 598 R D+ +H Sbjct: 312 HRPRAA-----DLLKHE 323 >4KIK-B nrPDB Length = 677 Score = 191 bits (486), Expect = 6e-49, Method: Composition-based stats. Identities = 62/211 (29%), Positives = 98/211 (46%), Gaps = 16/211 (7%) Query: 343 NFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPF 402 LG G FG V+ + T E A+K ++++ ++ + C +E +++ P Sbjct: 22 EMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWC--LEIQIMRRLT-HPN 78 Query: 403 LTQLHSCFQTMDRL------YFVMEYVNGGDLMYHIQQVGR---FKEPHAVFYAAEIAIG 453 + + M L MEY GGDL ++ Q +E + ++IA Sbjct: 79 VVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASA 138 Query: 454 LFFLQSKGIIYRDLKLDNVMLDSEGHI---KIADFGMCKENIWDGVTTKTFCGTPDYIAP 510 L +L II+RDLK +N++L KI D G KE G +F GT Y+AP Sbjct: 139 LRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKEL-DQGSLCTSFVGTLQYLAP 197 Query: 511 EIIAYQPYGKSVDWWAFGVLLYEMLAGQAPF 541 E++ Q Y +VD+W+FG L +E + G PF Sbjct: 198 ELLEQQKYTVTVDYWSFGTLAFECITGFRPF 228 >3RP9-A nrPDB Length = 458 Score = 190 bits (484), Expect = 1e-48, Method: Composition-based stats. Identities = 62/376 (16%), Positives = 122/376 (32%), Gaps = 106/376 (28%) Query: 340 TDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK 399 + ++G GS+G V + K + A+K + V D + + E +L Sbjct: 53 DRYEIRHLIGTGSYGHVCEAYDKLEKRVVAIKKI-LRVFEDLIDCKRILREIAILNRLNH 111 Query: 400 PPFLTQLHSCF----QTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 455 + L + D LY V+E + D + E H + +G+ Sbjct: 112 DHVVKVLDIVIPKDVEKFDELYVVLEIAD-SDFKKLFRTPVYLTELHIKTLLYNLLVGVK 170 Query: 456 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGV------------------- 496 ++ S GI++RDLK N +++ + +K+ DFG+ + + Sbjct: 171 YVHSAGILHRDLKPANCLVNQDCSVKVCDFGLARTVDYPENGNSQLPISPREDDMNLVTF 230 Query: 497 --------TTKTFCGTPDYIAPE-IIAYQPYGKSVDWWAFGVLLYEMLA----------- 536 T Y APE I+ + Y +++D W+ G + E+L Sbjct: 231 PHTKNLKRQLTGHVVTRWYRAPELILLQENYTEAIDVWSIGCIFAELLNMIKENVAYHAD 290 Query: 537 GQAPFEGED--------------------EDELFQSI----------------------- 553 F G + I Sbjct: 291 RGPLFPGSSCFPLSPDQKAGNDFKFHTRGNRDQLNVIFNILGTPSEEDIEALEKEDAKRY 350 Query: 554 ---------MEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYID 604 + +P S S +A+ + K ++ +P KR+ + H FF+ + Sbjct: 351 IRIFPKREGTDLAERFPAS-SADAIHLLKRMLVFNPNKRITI-----NECLAHPFFKEVR 404 Query: 605 WEKLE---RKEIQPPY 617 ++E ++++ P+ Sbjct: 405 IAEVETNATEKVRLPF 420 >2A1A-B nrPDB Length = 284 Score = 189 bits (479), Expect = 4e-48, Method: Composition-based stats. Identities = 67/262 (25%), Positives = 117/262 (44%), Gaps = 33/262 (12%) Query: 341 DFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKP 400 DF + ++G G FG+V ++ + + Y +K +K + E E + LA Sbjct: 12 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNN-------EKAEREVKALAKLDHV 64 Query: 401 PFLTQLHSCFQTMDR----------------LYFVMEYVNGGDLMYHIQQVG--RFKEPH 442 + + C+ D L+ ME+ + G L I++ + + Sbjct: 65 -NIVHYNGCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVL 123 Query: 443 AVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFC 502 A+ +I G+ ++ SK +I RDLK N+ L +KI DFG+ DG T++ Sbjct: 124 ALELFEQITKGVDYIHSKKLINRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRS-K 182 Query: 503 GTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEML-AGQAPFEGEDEDELFQSIMEHNVAYP 561 GT Y++PE I+ Q YGK VD +A G++L E+L FE + F + + ++ Sbjct: 183 GTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFET---SKFFTDLRDGIIS-- 237 Query: 562 KSMSKEAVAICKGLMTKHPGKR 583 K+ + + L++K P R Sbjct: 238 DIFDKKEKTLLQKLLSKKPEDR 259 >3LMG-A nrPDB Length = 344 Score = 189 bits (479), Expect = 5e-48, Method: Composition-based stats. Identities = 61/275 (22%), Positives = 113/275 (41%), Gaps = 15/275 (5%) Query: 317 PEEKTANTISKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKD 376 P EK +++ K T+ L VLG G FG V E + + K Sbjct: 16 PSEKANKVLARI--------FKETELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKV 67 Query: 377 VVIQDDDVECTMVEKRVLAL-PGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQ- 434 + + V +LA+ + +L L V +Y+ G L+ H++Q Sbjct: 68 IEDKSGRQSFQAVTDHMLAIGSLDHAHIVRLLGLC-PGSSLQLVTQYLPLGSLLDHVRQH 126 Query: 435 VGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWD 494 G + + +IA G+++L+ G+++R+L NV+L S +++ADFG+ D Sbjct: 127 RGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPD 186 Query: 495 GVT-TKTFCGTP-DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQ 551 + TP ++A E I + Y D W++GV ++E++ G P+ G E+ Sbjct: 187 DKQLLYSEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPD 246 Query: 552 SIMEHN-VAYPKSMSKEAVAICKGLMTKHPGKRLG 585 + + +A P+ + + + R Sbjct: 247 LLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPT 281 >5TQX-A nrPDB Length = 655 Score = 188 bits (477), Expect = 8e-48, Method: Composition-based stats. Identities = 66/276 (23%), Positives = 114/276 (41%), Gaps = 39/276 (14%) Query: 343 NFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPF 402 LG G FG V L + + D A+K + ++ ++ + C E +++ Sbjct: 11 EMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWC--HEIQIMKKLNHANV 68 Query: 403 LTQLHSCFQTMDRL-----YFVMEYVNGGDLMYHIQQVGR---FKEPHAVFYAAEIAIGL 454 + + ++ L MEY +GGDL + + KE + ++I G+ Sbjct: 69 VKAC-DVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSGI 127 Query: 455 FFLQSKGIIYRDLKLDNVML-DSEGHI--KIADFGMCKENIWDGVTTKTFCGTPDYIAPE 511 +L II+RDLK +N++L D G I KI D G K+ + G F GT Y+APE Sbjct: 128 RYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKD-VDQGELCTEFVGTLQYLAPE 186 Query: 512 IIAYQPYGKSVDWWAFGVLLYEMLAGQAPF-EGEDEDELFQSI-------------MEHN 557 + +PY +VD+W+FG +++E +AG PF + I M Sbjct: 187 LFENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPKCIFACEEMSGE 246 Query: 558 VAYPKSMS----------KEAVAICKGLMTKHPGKR 583 V + + + + ++ P +R Sbjct: 247 VRFSSHLPQPNSLCSLIVEPMENWLQLMLNWDPQQR 282 >5UNP-A nrPDB Length = 369 Score = 185 bits (471), Expect = 4e-47, Method: Composition-based stats. Identities = 57/329 (17%), Positives = 109/329 (33%), Gaps = 76/329 (23%) Query: 342 FNFLMVLGKGSFGKVMLSE-RKGTDELYAVKILKK-DVVIQDDDVECTMVEKRVLALPGK 399 + + LG+G+FG+V+ + A+KI+K + + +E ++EK P Sbjct: 36 YEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDN 95 Query: 400 PPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEP--HAVFYAAEIAIGLFFL 457 Q+ F + E + G ++ P A ++ + FL Sbjct: 96 KNLCVQMFDWFDYHGHMCISFELL-GLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFL 154 Query: 458 QSKGIIYRDLKLDNVML---------------DSEGH----IKIADFGMCKENIWDGVTT 498 + + DLK +N++ D +++ DFG +D Sbjct: 155 HDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSA---TFDHEHH 211 Query: 499 KTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDE---------- 548 T T Y APE+I + + D W+ G +++E G F+ D E Sbjct: 212 STIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILG 271 Query: 549 -----LFQSIMEHNVAY-----------------------PKSMSKEAV------AICKG 574 + + + Y + ++ EA + + Sbjct: 272 PIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIES 331 Query: 575 LMTKHPGKRLGCGPEGERDIKEHAFFRYI 603 ++ P KRL G + +H FF + Sbjct: 332 MLEYEPAKRLTLG-----EALQHPFFARL 355 >5UIU-A nrPDB Length = 323 Score = 185 bits (470), Expect = 5e-47, Method: Composition-based stats. Identities = 61/260 (23%), Positives = 100/260 (38%), Gaps = 23/260 (8%) Query: 347 VLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQL 406 +G+G FG V T AVK L V I ++++ ++ + + L +L Sbjct: 54 KMGEGGFGVVYKGYVNNT--TVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVEL 111 Query: 407 HSCFQTMDRLYFVMEYVNGGDLMYHI---QQVGRFKEPHAVFYAAEIAIGLFFLQSKGII 463 D L V Y+ G L+ + A A G+ FL I Sbjct: 112 LGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHI 171 Query: 464 YRDLKLDNVMLDSEGHIKIADFGMCK--ENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKS 521 +RD+K N++LD KI+DFG+ + E V T GT Y+APE + + Sbjct: 172 HRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEI-TPK 230 Query: 522 VDWWAFGVLLYEMLAGQAPFEGEDEDELFQS--------------IMEHNVAYPKSMSKE 567 D ++FGV+L E++ G + E +L ++ + S S E Sbjct: 231 SDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVE 290 Query: 568 A-VAICKGLMTKHPGKRLGC 586 A ++ + + KR Sbjct: 291 AMYSVASQCLHEKKNKRPDI 310 >3EB0-A nrPDB Length = 383 Score = 185 bits (469), Expect = 8e-47, Method: Composition-based stats. Identities = 61/334 (18%), Positives = 116/334 (34%), Gaps = 84/334 (25%) Query: 341 DFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKP 400 ++ LG GSFG V + + +A+K + +D ++ E ++ + Sbjct: 8 KYSLGKTLGTGSFGIVCEVFDIESGKRFALKKVLQDPRYKN-------RELDIMKVLDHV 60 Query: 401 PFLTQLHSCFQTMDR-------------------------------------LYFVMEYV 423 + + + T D L +MEYV Sbjct: 61 NIIKLVDYFYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNVIMEYV 120 Query: 424 N---GGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDS-EGH 479 L I+ Y ++ + F+ S GI +RD+K N++++S + Sbjct: 121 PDTLHKVLKSFIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLLVNSKDNT 180 Query: 480 IKIADFGMCKENIWDGVTTKTFCGTPDYIAPE-IIAYQPYGKSVDWWAFGVLLYEMLAGQ 538 +K+ DFG K+ I + C + Y APE ++ Y S+D W+ G + E++ G+ Sbjct: 181 LKLCDFGSAKKLIPSEPSVAYIC-SRFYRAPELMLGATEYTPSIDLWSIGCVFGELILGK 239 Query: 539 APFEGEDEDELFQSIME------------HNVAY-----------------PKSMSKEAV 569 F GE + I++ N Y P+ A+ Sbjct: 240 PLFSGETSIDQLVRIIQIMGTPTKEQMIRMNPHYTEVRFPTLKAKDWRKILPEGTPSLAI 299 Query: 570 AICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYI 603 + + ++ P R+ + H FF ++ Sbjct: 300 DLLEQILRYEPDLRI-----NPYEAMAHPFFDHL 328 >5TOS-A nrPDB Length = 395 Score = 184 bits (468), Expect = 8e-47, Method: Composition-based stats. Identities = 71/291 (24%), Positives = 123/291 (42%), Gaps = 47/291 (16%) Query: 335 DRMKLT--DFNFLMVLGKGSFGKVMLS---------ERKGTDELYAVKILKKDVVIQDDD 383 + +KL +F V+G+G FG V + GT + AVK L ++ + Sbjct: 58 NELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHRE 117 Query: 384 VECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHA 443 + E L P + + C + RL V E++ G L H+ + G + +P Sbjct: 118 W---LTEINYLGQLSHPNLVKLIGYCLEDEHRL-LVYEFMQKGSLENHLFRRGAYFKPLP 173 Query: 444 VFY----AAEIAIGLFFLQSK--GIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDG-- 495 F A + A GL FL S +IYRD+K N++LD++ + K++DFG+ ++ Sbjct: 174 WFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLS 233 Query: 496 VTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQ----------------- 538 + GT Y APE ++ D ++FGVLL E+L+G+ Sbjct: 234 YVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDW 293 Query: 539 -APFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICK---GLMTKHPGKRLG 585 P+ L I+++ + + + +EAV + ++ P R Sbjct: 294 ARPYLTSKRKVLL--IVDNRLDT-QYLPEEAVRMASVAVQCLSFEPKSRPT 341 >3UIU-A nrPDB Length = 306 Score = 183 bits (464), Expect = 3e-46, Method: Composition-based stats. Identities = 66/275 (24%), Positives = 118/275 (42%), Gaps = 46/275 (16%) Query: 341 DFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKP 400 DF + ++G G FG+V ++ + + Y ++ +K + E E + LA Sbjct: 13 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIRRVKYNN-------EKAEREVKALAKLDHV 65 Query: 401 PFLTQLHSCFQTMDR-----------------------------LYFVMEYVNGGDLMYH 431 + + C+ D L+ ME+ + G L Sbjct: 66 -NIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQW 124 Query: 432 IQQVG--RFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCK 489 I++ + + A+ +I G+ ++ SK +I+RDLK N+ L +KI DFG+ Sbjct: 125 IEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVT 184 Query: 490 ENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEML-AGQAPFEGEDEDE 548 DG T++ GT Y++PE I+ Q YGK VD +A G++L E+L FE + Sbjct: 185 SLKNDGKRTRS-KGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFET---SK 240 Query: 549 LFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKR 583 F + + ++ K+ + + L++K P R Sbjct: 241 FFTDLRDGIIS--DIFDKKEKTLLQKLLSKKPEDR 273 >6J5U-C nrPDB Length = 426 Score = 182 bits (461), Expect = 6e-46, Method: Composition-based stats. Identities = 71/278 (25%), Positives = 118/278 (42%), Gaps = 41/278 (14%) Query: 341 DFNFLMVLGKGSFGKVML---------SERKGTDELYAVKILKKDVVIQDDDVECTMVEK 391 +F +LG+G FG V + R G+ + AVK LK + + + E Sbjct: 85 NFRQDNLLGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQLKPEGFQGHKEW---LTEV 141 Query: 392 RVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEI- 450 L P + + C + +RL V E++ G L H+ + G A+ + Sbjct: 142 NYLGQLSHPNLVLLVGYCAEGENRL-LVYEFMPKGSLENHLFRRGAQPLTWAIRMKVAVG 200 Query: 451 -AIGLFFLQSKG--IIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVT--TKTFCGTP 505 A GL FL +IYRD K N++LD++ + K++DFG+ K T + GT Sbjct: 201 AAKGLTFLHEAKSQVIYRDFKAANILLDADFNAKLSDFGLAKAGPTGDNTHVSTKVIGTH 260 Query: 506 DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQ------------------APFEGEDED 547 Y APE +A D ++FGV+L E+++G+ P+ G D+ Sbjct: 261 GYAAPEYVATGRLTAKSDVYSFGVVLLELISGRRAMDNSNGGNEYSLVDWATPYLG-DKR 319 Query: 548 ELFQSIMEHNV--AYPKSMSKEAVAICKGLMTKHPGKR 583 +LF+ IM+ + YP+ + A + + R Sbjct: 320 KLFR-IMDTKLGGQYPQKGAFTAANLALQCLNPDAKLR 356 >5TE0-A nrPDB Length = 347 Score = 180 bits (457), Expect = 2e-45, Method: Composition-based stats. Identities = 65/308 (21%), Positives = 114/308 (37%), Gaps = 44/308 (14%) Query: 332 GNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEK 391 G + VL +G F V L A+K + V + D++ E Sbjct: 11 GRVFGIGRQQVTVDEVLAEGGFAIVFLVR-TSNGMKCALKRM---FVNNEHDLQVCKREI 66 Query: 392 RVLALPGKPPFLTQLHSC----FQTMD--RLYFVMEYVNGGDLMYHIQQV--GRFKEPHA 443 +++ + + D + +M++ GG ++ + Q F E Sbjct: 67 QIMRDLSGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEV 126 Query: 444 VFYAAEIAIGLFFLQSKG--IIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTF 501 + + + L II+RDLK++N++L GH + DFG + T Sbjct: 127 LQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVN 186 Query: 502 CG--------TPDYIAPEIIA---YQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELF 550 T Y APE++ + D WA G LLY++ PF GE + Sbjct: 187 AVEDEIKKYTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPF-GESQV--- 242 Query: 551 QSIMEHNVAYPKS--MSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKL 608 +I + N P + S++ + + ++ P KR DI + ++F + KL Sbjct: 243 -AICDGNFTIPDNSRYSQDMHCLIRYMLEPDPDKR--------PDIYQVSYFSF----KL 289 Query: 609 ERKEIQPP 616 +KE P Sbjct: 290 LKKECPIP 297 >2RIO-A nrPDB Length = 434 Score = 180 bits (456), Expect = 2e-45, Method: Composition-based stats. Identities = 71/324 (21%), Positives = 127/324 (39%), Gaps = 58/324 (17%) Query: 346 MVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQ 405 +LG GS G V+ + AVK + D + ++E ++L P + + Sbjct: 21 KILGYGSSGTVVF-QGSFQGRPVAVKRMLIDFC------DIALMEIKLLTESDDHPNVIR 73 Query: 406 LHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPH-------AVFYAAEIAIGLFFLQ 458 + T LY +E N +L ++ E + +IA G+ L Sbjct: 74 YYCSETTDRFLYIALELCNL-NLQDLVESKNVSDENLKLQKEYNPISLLRQIASGVAHLH 132 Query: 459 SKGIIYRDLKLDNVMLD-------------SEGHIKIADFGMCKENIWDGVTTKTF---- 501 S II+RDLK N+++ I I+DFG+CK+ + +T Sbjct: 133 SLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFRTNLNNP 192 Query: 502 CGTPDYIAPEIIA-------YQPYGKSVDWWAFGVLLYEMLA-GQAPFEGE--DEDELFQ 551 GT + APE++ + +S+D ++ G + Y +L+ G+ PF + E + + Sbjct: 193 SGTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPFGDKYSRESNIIR 252 Query: 552 SIM---EHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKL 608 I E + +S+ EA + ++ P KR + H F W K Sbjct: 253 GIFSLDEMKCLHDRSLIAEATDLISQMIDHDPLKRPTAMK-----VLRHPLF----WPK- 302 Query: 609 ERKEIQPPYKPKARDKRDTSNFDK 632 K+++ + K D+ + N D Sbjct: 303 -SKKLE--FLLKVSDRLEIENRDP 323 >6O6Q-A nrPDB Length = 335 Score = 179 bits (455), Expect = 3e-45, Method: Composition-based stats. Identities = 58/302 (19%), Positives = 109/302 (36%), Gaps = 56/302 (18%) Query: 340 TDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK 399 ++ L LG+G + +V L E +K+LK + E +L Sbjct: 41 ENYEILRKLGRGKYSEVFLGIDLEKREKVVIKVLKPVK------RKKIKREISILKNLVD 94 Query: 400 PPFLTQLHSCFQTM--DRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFL 457 P + + + + E++N D F + FY E+ L + Sbjct: 95 GPNIIAMLDVVREPQSKTPGLIFEHINNIDFRSL---YPTFTDYDIRFYMYELLKALDYS 151 Query: 458 QSKGIIYRDLKLDNVMLDSEGH-IKIADFGMCKENIWDGVTTKTFCGTPDYIAPEII-AY 515 S GI++RD+K NVM+D + +++ D+G+ E G + + PE++ Y Sbjct: 152 HSMGIMHRDVKPHNVMIDHDKKLLRLIDWGLA-EYYHPGTEYNVRVASRYFKGPELLVDY 210 Query: 516 QPYGKSVDWWAFGVLLYEMLAGQAP-FEGEDEDELFQSIME-----------HNVAYP-- 561 + Y S+D W+FG +L M+ + P F G+ + I+ Sbjct: 211 RLYDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQLVQIVRVLGSKNFKKYLEKYNISLG 270 Query: 562 -----------------------KSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHA 598 +S+E + + L+ +RL ++ +HA Sbjct: 271 EEYEDIGYYNKRQWVRFMNENNKDLVSQEFLDLIDRLLRYDHQERLTA-----KEAMKHA 325 Query: 599 FF 600 +F Sbjct: 326 YF 327 >5L2Q-C nrPDB Length = 320 Score = 179 bits (455), Expect = 3e-45, Method: Composition-based stats. Identities = 75/292 (25%), Positives = 127/292 (43%), Gaps = 45/292 (15%) Query: 357 MLSERKGTDELYAVKILKKDV-----VIQDDDVECTMV---EKRVLALPGKPPFLTQLHS 408 L+ + GTD+ Y +KIL + + ++ + M+ E +L+L + H Sbjct: 33 CLARKDGTDDFYQLKILTLEERGDQGIESQEERQGKMLLHTEYSLLSLLHTQDGVVHHHG 92 Query: 409 CFQT------------------MDRLYFVMEYVNGGD----------LMYHIQQVGRFKE 440 FQ R+ V++ + D L +++ + R E Sbjct: 93 LFQDRTCEIVEDTESSRMVKKMKKRICLVLDCLCAHDFSDKTADLINLQHYVIKEKRLSE 152 Query: 441 PHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGH-IKIADFGMCKENIWDGVTTK 499 V ++ + L K I++RDLKL N++L+ H I I +F + K + +G K Sbjct: 153 RETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEGDLLK 212 Query: 500 TFCGTPDYIAPEIIAYQPY-GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNV 558 G+P YI+P++++ +PY GK D WA GV+L+ ML GQ PF ELF+ I Sbjct: 213 DQRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPFYDSIPQELFRKIKAAEY 272 Query: 559 AYPKS--MSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKL 608 P+ +S+ V + + L+ P +RL D+ E W+ L Sbjct: 273 TIPEDGRVSENTVCLIRKLLVLDPQQRLAAA-----DVLEALSAIIASWQSL 319 >2H34-A nrPDB Length = 309 Score = 179 bits (454), Expect = 4e-45, Method: Composition-based stats. Identities = 58/257 (22%), Positives = 109/257 (42%), Gaps = 7/257 (2%) Query: 333 NRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKR 392 +R+ + + ++G+G G V +E + + A+K++ + + E R Sbjct: 27 SREGTQFGPYRLRRLVGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPVFRTRMQREAR 86 Query: 393 VLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAI 452 A + P + +H + +LY M +NG DL +++ G P AV +I Sbjct: 87 T-AGRLQEPHVVPIHDFGEIDGQLYVDMRLINGVDLAAMLRRQGPLAPPRAVAIVRQIGS 145 Query: 453 GLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVT-TKTFCGTPDYIAPE 511 L + G +RD+K +N+++ ++ + DFG+ + +T GT Y+APE Sbjct: 146 ALDAAHAAGATHRDVKPENILVSADDFAYLVDFGIASATTDEKLTQLGNTVGTLYYMAPE 205 Query: 512 IIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDED----ELFQSIMEHNVAYPKSMSKE 567 + D +A +LYE L G P++G+ + Q+I + P + Sbjct: 206 RFSESHATYRADIYALTCVLYECLTGSPPYQGDQLSVMGAHINQAIPRPSTVRP-GIPVA 264 Query: 568 AVAICKGLMTKHPGKRL 584 A+ M K+P R Sbjct: 265 FDAVIARGMAKNPEDRY 281 >2PMN-X nrPDB Length = 348 Score = 179 bits (453), Expect = 5e-45, Method: Composition-based stats. Identities = 63/317 (19%), Positives = 121/317 (38%), Gaps = 55/317 (17%) Query: 339 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDV-------------- 384 + D+ + L +G F K++L E+ ++ YA+K +K ++ + D Sbjct: 30 INDYRIIRTLNQGKFNKIILCEK--DNKFYALKKYEKSLLEKKRDFTKSNNDKISIKSKY 87 Query: 385 ECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAV 444 + E +++ + D +Y + EY+ ++ + + + Sbjct: 88 DDFKNELQIITDIKN-EYCLTCEGIITNYDEVYIIYEYMENDSILKFDEYFFVLDKNYTC 146 Query: 445 FYAAEIAIGL--------FFLQ-SKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDG 495 F ++ + ++ K I +RD+K N+++D G +K++DFG + + Sbjct: 147 FIPIQVIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMDKNGRVKLSDFGESEYMV--D 204 Query: 496 VTTKTFCGTPDYIAPEII-AYQPY-GKSVDWWAFGVLLYEMLAGQAPFE-GEDEDELFQS 552 K GT +++ PE Y G VD W+ G+ LY M PF ELF + Sbjct: 205 KKIKGSRGTYEFMPPEFFSNESSYNGAKVDIWSLGICLYVMFYNVVPFSLKISLVELFNN 264 Query: 553 IMEHNVAYP-------------------KSMSKEAVAICKGLMTKHPGKRLGCGPEGERD 593 I N+ YP +S E + K + K+P +R+ D Sbjct: 265 IRTKNIEYPLDRNHFLYPLTNKKSTCSNNFLSNEDIDFLKLFLRKNPAERIT-----SED 319 Query: 594 IKEHAFFRYIDWEKLER 610 +H + + E L Sbjct: 320 ALKHEWLADTNIEDLRE 336 >5CEK-A nrPDB Length = 263 Score = 178 bits (452), Expect = 7e-45, Method: Composition-based stats. Identities = 50/208 (24%), Positives = 87/208 (41%), Gaps = 10/208 (4%) Query: 400 PPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQS 459 +T + + Y E + GD+ +++ R +E A +I + Sbjct: 60 HSNITGIVEVILGETKAYVFFEK-DFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQ 118 Query: 460 KGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGV--TTKTFCGTPDYIAPEIIAY-Q 516 I+ DLKL + +E ++ + +I G G P Y++PEI+ Sbjct: 119 SAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTG 178 Query: 517 PY-GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGL 575 Y GK+ D W+ GV+LY +L G+ PF D LF I P+ +S +A + + L Sbjct: 179 TYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKARCLIRSL 238 Query: 576 MTKHPGKRLGCGPEGERDIKEHAFFRYI 603 + + P +RL +I H +F + Sbjct: 239 LRREPSERLTA-----PEILLHPWFESV 261 >6DC0-A nrPDB Length = 292 Score = 178 bits (451), Expect = 8e-45, Method: Composition-based stats. Identities = 50/208 (24%), Positives = 87/208 (41%), Gaps = 10/208 (4%) Query: 400 PPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQS 459 +T + + Y E + GD+ +++ R +E A +I + Sbjct: 57 HSNITGIVEVILGETKAYVFFEK-DFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQ 115 Query: 460 KGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGV--TTKTFCGTPDYIAPEIIAY-Q 516 I+ DLKL + +E ++ + +I G G P Y++PEI+ Sbjct: 116 SAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTG 175 Query: 517 PY-GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGL 575 Y GK+ D W+ GV+LY +L G+ PF D LF I P+ +S +A + + L Sbjct: 176 TYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKARCLIRSL 235 Query: 576 MTKHPGKRLGCGPEGERDIKEHAFFRYI 603 + + P +RL +I H +F + Sbjct: 236 LRREPSERLTA-----PEILLHPWFESV 258 >3RAW-A nrPDB Length = 381 Score = 177 bits (450), Expect = 1e-44, Method: Composition-based stats. Identities = 55/329 (16%), Positives = 107/329 (32%), Gaps = 76/329 (23%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDE-LYAVKILKKDVVIQDDDVECTMVEKRVLALPGKP 400 + + LG+G+FGKV+ + A+KI++ ++ V K++ + Sbjct: 53 YEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKEN 112 Query: 401 PFL-TQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVG--RFKEPHAVFYAAEIAIGLFFL 457 FL + F + E + G + +++ + PH A ++ L FL Sbjct: 113 KFLCVLMSDWFNFHGHMCIAFELL-GKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFL 171 Query: 458 QSKGIIYRDLKLDNVMLDS-------------------EGHIKIADFGMCKENIWDGVTT 498 + + DLK +N++ + I++ADFG +D Sbjct: 172 HENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSA---TFDHEHH 228 Query: 499 KTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNV 558 T T Y PE+I + + D W+ G +L+E G F+ + E + + Sbjct: 229 TTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILG 288 Query: 559 AYPKSM--------------------SKEAV------------------------AICKG 574 P M S + + + Sbjct: 289 PIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRR 348 Query: 575 LMTKHPGKRLGCGPEGERDIKEHAFFRYI 603 ++ P +R+ + H FF + Sbjct: 349 MLEFDPAQRITLA-----EALLHPFFAGL 372 >4JLC-A nrPDB Length = 657 Score = 177 bits (449), Expect = 2e-44, Method: Composition-based stats. Identities = 57/234 (24%), Positives = 98/234 (41%), Gaps = 25/234 (10%) Query: 347 VLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQL 406 +LG+G+ V K T +LYAVK+ ++ DV+ M E VL + +L Sbjct: 15 ILGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQ--MREFEVLKKLN-HKNIVKL 71 Query: 407 HSCFQ--TMDRLYFVMEYVNGGDLMYHIQQVGR---FKEPHAVFYAAEIAIGLFFLQSKG 461 + + T +ME+ G L +++ E + ++ G+ L+ G Sbjct: 72 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 131 Query: 462 IIYRDLKLDNVM--LDSEGH--IKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA--- 514 I++RD+K N+M + +G K+ DFG +E D + GT +Y+ P++ Sbjct: 132 IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAAREL-EDDEQFVSLYGTEEYLHPDMYERAV 190 Query: 515 -----YQPYGKSVDWWAFGVLLYEMLAGQAPFE----GEDEDELFQSIMEHNVA 559 + YG +VD W+ GV Y G PF E+ I+ + Sbjct: 191 LRKDHQKKYGATVDLWSVGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS 244 >3Q4U-A nrPDB Length = 301 Score = 177 bits (448), Expect = 2e-44, Method: Composition-based stats. Identities = 62/292 (21%), Positives = 102/292 (34%), Gaps = 46/292 (15%) Query: 336 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 395 R D L +GKG +G+V + E AVKI E + +L Sbjct: 4 RTVARDITLLECVGKGRYGEVWRGSWQ--GENVAVKIFSSRDEKSW-FRETELYNTVMLR 60 Query: 396 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 455 F+ + + +L+ + Y G L ++ Q+ + IA GL Sbjct: 61 HENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYL-QLTTLDTVSCLRIVLSIASGLA 119 Query: 456 FLQ--------SKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKT----FCG 503 L I +RDLK N+++ G IAD G+ + G Sbjct: 120 HLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVG 179 Query: 504 TPDYIAPEII-------AYQPYGKSVDWWAFGVLLYEMLAG----------QAPFEG--- 543 T Y+APE++ + Y K VD WAFG++L+E+ + PF Sbjct: 180 TKRYMAPEVLDETIQVDCFDSY-KRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVP 238 Query: 544 -EDEDELFQSIMEHNVAYP----KSMSKE----AVAICKGLMTKHPGKRLGC 586 + E + ++ + P + S + K ++P RL Sbjct: 239 NDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTA 290 >4IAN-A nrPDB Length = 358 Score = 176 bits (447), Expect = 2e-44, Method: Composition-based stats. Identities = 56/257 (21%), Positives = 111/257 (43%), Gaps = 9/257 (3%) Query: 314 TKAPEEKTANTISKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGT-DELYAVKI 372 + P + T ++ N + +N G+G F V+ + ++ AVKI Sbjct: 4 KENPNLRDNWTDAEGYYRVNIGEVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKI 63 Query: 373 LKKDVVIQDDDVEC-TMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYH 431 ++ + ++Q ++ ++K A P +L F L V E ++ +L Sbjct: 64 IRNNELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSM-NLREV 122 Query: 432 IQQVGR---FKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHI-KIADFGM 487 +++ G+ Y+ ++ + L L+ I++ D+K DN++++ I K+ DFG Sbjct: 123 LKKYGKDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGS 182 Query: 488 CKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDED 547 + +T + + Y APEII + Y +D W+ G LYE+ G+ F G+ + Sbjct: 183 ASHVADNDITP--YLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNN 240 Query: 548 ELFQSIMEHNVAYPKSM 564 + + M+ P M Sbjct: 241 HMLKLAMDLKGKMPNKM 257 >5AR8-A nrPDB Length = 326 Score = 176 bits (447), Expect = 2e-44, Method: Composition-based stats. Identities = 58/270 (21%), Positives = 114/270 (42%), Gaps = 26/270 (9%) Query: 338 KLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALP 397 KL D +L +G+ G V + AVK L + D + + + E +L Sbjct: 33 KLADLRYLS---RGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKA 89 Query: 398 GKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKE---PHAVFYAAEIAIGL 454 ++ + + L V EY+ G L + + + + P EIA+G+ Sbjct: 90 RFS-YILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGV 148 Query: 455 FFLQSK--GIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFC-----GTPDY 507 +L + +++ DLK N++LD+E H+KIADFG+ K + +++ GT Y Sbjct: 149 NYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIY 208 Query: 508 IAPEII---AYQPYGKSVDWWAFGVLLYEMLAGQAPFEG-EDEDELFQSIMEH------N 557 + PE D +++ V+ +E+L+ + PFE + ++ S+ + Sbjct: 209 MPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINE 268 Query: 558 VAYPKSMSKEAV--AICKGLMTKHPGKRLG 585 + P + A ++ + ++P +R Sbjct: 269 ESLPYDIPHRARMISLIESGWAQNPDERPS 298 >5WNL-A nrPDB Length = 342 Score = 175 bits (445), Expect = 4e-44, Method: Composition-based stats. Identities = 52/255 (20%), Positives = 98/255 (38%), Gaps = 20/255 (7%) Query: 346 MVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQ 405 +G G FG+V A+K + + D + + E + + + L Sbjct: 26 EKVGSGGFGQVYKVRHVHWKTWLAIK-CSPSLHVDDRERMELLEEAKKMEMAKFRYILPV 84 Query: 406 LHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQ--SKGII 463 C + + VMEY+ G L + E A+G+ FL S ++ Sbjct: 85 YGIC---QEPVGLVMEYMETGSLEKLLASE-PLPWDLRFRIVHETAVGMNFLHCMSPPLL 140 Query: 464 YRDLKLDNVMLDSEGHIKIADFGMCKENIW---DGVTTKTFCGTPDYIAPEIIAYQP--Y 518 + +LK N++LD+ H+KI+DFG+ K N ++ GT Y+ PE I + + Sbjct: 141 HLNLKPANILLDAHYHVKISDFGLAKCNGMSHSHDLSMDGLFGTIAYLPPERIREKSRLF 200 Query: 519 GKSVDWWAFGVLLYEMLAGQAPFEGEDED-ELFQSIME-HNVAYPKSMSK------EAVA 570 D ++F ++++ +L + PF E + +++ H P + Sbjct: 201 DTKHDVYSFAIVIWGVLTQKKPFADEKNILHIMMKVVKGHRPELPPICRPRPRACASLIG 260 Query: 571 ICKGLMTKHPGKRLG 585 + + P R Sbjct: 261 LMQRCWHADPQVRPT 275 >4EUU-A nrPDB Length = 319 Score = 175 bits (445), Expect = 4e-44, Method: Composition-based stats. Identities = 54/234 (23%), Positives = 98/234 (41%), Gaps = 25/234 (10%) Query: 347 VLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQL 406 +LG+G+ V K T +L+A+K+ ++ DV+ M E VL + +L Sbjct: 16 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLN-HKNIVKL 72 Query: 407 HSCFQ--TMDRLYFVMEYVNGGDLMYHIQQVGR---FKEPHAVFYAAEIAIGLFFLQSKG 461 + + T +ME+ G L +++ E + ++ G+ L+ G Sbjct: 73 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 132 Query: 462 IIYRDLKLDNVM--LDSEGH--IKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA--- 514 I++R++K N+M + +G K+ DFG +E D + GT +Y+ P++ Sbjct: 133 IVHRNIKPGNIMRVIGEDGQSVYKLTDFGAAREL-EDDEQFVSLYGTEEYLHPDMYERAV 191 Query: 515 -----YQPYGKSVDWWAFGVLLYEMLAGQAPFE----GEDEDELFQSIMEHNVA 559 + YG +VD W+ GV Y G PF E+ I+ + Sbjct: 192 LRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS 245 >3QD2-B nrPDB Length = 332 Score = 175 bits (445), Expect = 4e-44, Method: Composition-based stats. Identities = 68/340 (20%), Positives = 124/340 (36%), Gaps = 87/340 (25%) Query: 339 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 398 LTDF + +G+G FG V ++ K D YA+K ++ + ++ E M E + LA Sbjct: 5 LTDFEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIR--LPNRELAREKVMREVKALAKLE 62 Query: 399 KPPFL--------------------------------------------TQLHSCFQTMD 414 P + + F T + Sbjct: 63 HPGIVRYFNAWLETPPEKWQEEMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFSTKN 122 Query: 415 ------------RLYFVMEYVNGGDLMYHIQQVGRFKEPH---AVFYAAEIAIGLFFLQS 459 LY M+ +L + + ++ + +IA + FL S Sbjct: 123 TVGQLQPSSPKVYLYIQMQLCRKENLKDWMNRRCSLEDREHGVCLHIFIQIAEAVEFLHS 182 Query: 460 KGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGV------------TTKTFCGTPDY 507 KG+++RDLK N+ + +K+ DFG+ D T GT Y Sbjct: 183 KGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQVGTKLY 242 Query: 508 IAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIME-HNVAYPKSMS- 565 ++PE I Y VD ++ G++L+E+L + + E + I + N+ +P + Sbjct: 243 MSPEQIHGNNYSHKVDIFSLGLILFELL-----YSFSTQMERVRIITDVRNLKFPLLFTQ 297 Query: 566 --KEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYI 603 + + + +++ P +R DI E+A F + Sbjct: 298 KYPQEHMMVQDMLSPSPTER-----PEATDIIENAIFENL 332 >4EUT-A nrPDB Length = 396 Score = 175 bits (444), Expect = 5e-44, Method: Composition-based stats. Identities = 54/234 (23%), Positives = 98/234 (41%), Gaps = 25/234 (10%) Query: 347 VLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQL 406 +LG+G+ V K T +L+A+K+ ++ DV+ M E VL + +L Sbjct: 16 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLN-HKNIVKL 72 Query: 407 HSCFQ--TMDRLYFVMEYVNGGDLMYHIQQVGR---FKEPHAVFYAAEIAIGLFFLQSKG 461 + + T +ME+ G L +++ E + ++ G+ L+ G Sbjct: 73 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 132 Query: 462 IIYRDLKLDNVM--LDSEGH--IKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA--- 514 I++R++K N+M + +G K+ DFG +E D + GT +Y+ P++ Sbjct: 133 IVHRNIKPGNIMRVIGEDGQSVYKLTDFGAAREL-EDDEQFVSLYGTEEYLHPDMYERAV 191 Query: 515 -----YQPYGKSVDWWAFGVLLYEMLAGQAPFE----GEDEDELFQSIMEHNVA 559 + YG +VD W+ GV Y G PF E+ I+ + Sbjct: 192 LRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS 245 >5LPZ-A nrPDB Length = 332 Score = 174 bits (441), Expect = 1e-43, Method: Composition-based stats. Identities = 65/268 (24%), Positives = 104/268 (38%), Gaps = 32/268 (11%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 F+ ++G G FG V + K A+K L D + M E + K Sbjct: 19 FHNDSLIGSGGFGDVYKAILK-DGSAVAIKKLIHVSGQGDRE---FMAEMETIGKI-KHR 73 Query: 402 FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR----FKEPHAVFYAAEIAIGLFFL 457 L L + D V E++ G L + + A A GL FL Sbjct: 74 NLVPLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFL 133 Query: 458 Q---SKGIIYRDLKLDNVMLDSEGHIKIADFGMCKEN--IWDGVTTKTFCGTPDYIAPEI 512 S II+RD+K NV+LD +++DFGM + + ++ T GTP Y+ PE Sbjct: 134 HHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEY 193 Query: 513 IAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGED--EDELFQSIMEH-NVAYPKSMSKEAV 569 D +++GV+L E+L G+ P + D ++ L + +H + E Sbjct: 194 YQSFRCSTKGDVYSYGVVLLELLTGKRPTDSPDFGDNNLVGWVKQHAKLRISDVFDPE-- 251 Query: 570 AICKGLMTKHPGKRLGCGPEGERDIKEH 597 LM + P E ++ +H Sbjct: 252 -----LMKEDPA--------LEIELLQH 266 >3UIM-A nrPDB Length = 326 Score = 174 bits (440), Expect = 2e-43, Method: Composition-based stats. Identities = 59/235 (25%), Positives = 99/235 (42%), Gaps = 13/235 (5%) Query: 317 PEEKTANTISKFDNNGNRD-RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKK 375 EE + + R+ ++ +F+ +LG+G FGKV L AVK LK+ Sbjct: 6 AEEDPEVHLGQLKRFSLRELQVASDNFSNKNILGRGGFGKVYKGRL-ADGTLVAVKRLKE 64 Query: 376 DVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQV 435 + + E ++++ L C +RL V Y+ G + +++ Sbjct: 65 ERTQGGE--LQFQTEVEMISMAVHRNLLRLRGFCMTPTERL-LVYPYMANGSVASCLRER 121 Query: 436 G----RFKEPHAVFYAAEIAIGLFFLQSK---GIIYRDLKLDNVMLDSEGHIKIADFGMC 488 P A A GL +L II+RD+K N++LD E + DFG+ Sbjct: 122 PESQPPLDWPKRQRIALGSARGLAYLHDHCDPKIIHRDVKAANILLDEEFEAVVGDFGLA 181 Query: 489 KENIWDGVTTKTFC-GTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFE 542 K + T GT +IAPE ++ + D + +GV+L E++ GQ F+ Sbjct: 182 KLMDYKDTHVTTAVRGTIGHIAPEYLSTGKSSEKTDVFGYGVMLLELITGQRAFD 236 >5LPV-A nrPDB Length = 296 Score = 174 bits (440), Expect = 2e-43, Method: Composition-based stats. Identities = 65/268 (24%), Positives = 104/268 (38%), Gaps = 32/268 (11%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 F+ ++G G FG V + K A+K L D + M E + K Sbjct: 19 FHNDSLIGSGGFGDVYKAILK-DGSAVAIKKLIHVSGQGDRE---FMAEMETIGKI-KHR 73 Query: 402 FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR----FKEPHAVFYAAEIAIGLFFL 457 L L + D V E++ G L + + A A GL FL Sbjct: 74 NLVPLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFL 133 Query: 458 Q---SKGIIYRDLKLDNVMLDSEGHIKIADFGMCKEN--IWDGVTTKTFCGTPDYIAPEI 512 S II+RD+K NV+LD +++DFGM + + ++ T GTP Y+ PE Sbjct: 134 HHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEY 193 Query: 513 IAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGED--EDELFQSIMEH-NVAYPKSMSKEAV 569 D +++GV+L E+L G+ P + D ++ L + +H + E Sbjct: 194 YQSFRCSTKGDVYSYGVVLLELLTGKRPTDSPDFGDNNLVGWVKQHAKLRISDVFDPE-- 251 Query: 570 AICKGLMTKHPGKRLGCGPEGERDIKEH 597 LM + P E ++ +H Sbjct: 252 -----LMKEDPA--------LEIELLQH 266 >6NT9-A nrPDB Length = 742 Score = 173 bits (438), Expect = 2e-43, Method: Composition-based stats. Identities = 54/234 (23%), Positives = 98/234 (41%), Gaps = 25/234 (10%) Query: 347 VLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQL 406 +LG+G+ V K T +L+A+K+ ++ DV+ M E VL + +L Sbjct: 14 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLN-HKNIVKL 70 Query: 407 HSCFQ--TMDRLYFVMEYVNGGDLMYHIQQVGR---FKEPHAVFYAAEIAIGLFFLQSKG 461 + + T +ME+ G L +++ E + ++ G+ L+ G Sbjct: 71 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 130 Query: 462 IIYRDLKLDNVM--LDSEGH--IKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA--- 514 I++R++K N+M + +G K+ DFG +E D + GT +Y+ P++ Sbjct: 131 IVHRNIKPGNIMRVIGEDGQSVYKLTDFGAAREL-EDDEQFVSLYGTEEYLHPDMYERAV 189 Query: 515 -----YQPYGKSVDWWAFGVLLYEMLAGQAPFE----GEDEDELFQSIMEHNVA 559 + YG +VD W+ GV Y G PF E+ I+ + Sbjct: 190 LRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS 243 >6O8B-A nrPDB Length = 665 Score = 172 bits (437), Expect = 4e-43, Method: Composition-based stats. Identities = 54/234 (23%), Positives = 97/234 (41%), Gaps = 25/234 (10%) Query: 347 VLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQL 406 +LG+G+ V K T +L+A+K+ ++ DV+ M E VL + +L Sbjct: 22 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLN-HKNIVKL 78 Query: 407 HSCFQ--TMDRLYFVMEYVNGGDLMYHIQQVGR---FKEPHAVFYAAEIAIGLFFLQSKG 461 + + T +ME+ G L +++ E + ++ G+ L+ G Sbjct: 79 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 138 Query: 462 IIYRDLKLDNVM--LDSEGH--IKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA--- 514 I++R++K N+M + +G K+ DFG +E D GT +Y+ P++ Sbjct: 139 IVHRNIKPGNIMRVIGEDGQSVYKLTDFGAAREL-EDDEQFVELYGTEEYLHPDMYERAV 197 Query: 515 -----YQPYGKSVDWWAFGVLLYEMLAGQAPFE----GEDEDELFQSIMEHNVA 559 + YG +VD W+ GV Y G PF E+ I+ + Sbjct: 198 LRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS 251 >4MD7-E nrPDB Length = 391 Score = 172 bits (436), Expect = 4e-43, Method: Composition-based stats. Identities = 64/310 (20%), Positives = 114/310 (36%), Gaps = 57/310 (18%) Query: 340 TDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK 399 D+ + LG+G + +V + +E +++ + E ++L Sbjct: 37 DDYQLVRKLGRGKYSEVFEAINITNNEK------VVVKILKPVKKKKIKREIKILENLRG 90 Query: 400 PPFLTQLHSCFQTM--DRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFL 457 P + L + V E+VN D Q + FY EI L + Sbjct: 91 GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYC 147 Query: 458 QSKGIIYRDLKLDNVMLDSEGH-IKIADFGMCKENIWDGVTTKTFCGTPDYIAPEII-AY 515 S GI++RD+K NVM+D E +++ D+G+ E G + + PE++ Y Sbjct: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLVDY 206 Query: 516 QPYGKSVDWWAFGVLLYEMLAGQAPF-EGEDE-------------DELFQSIMEHNVAYP 561 Q Y S+D W+ G +L M+ + PF G D ++L+ I ++N+ Sbjct: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 266 Query: 562 KS------------------------MSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEH 597 +S EA+ L+ RL R+ EH Sbjct: 267 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTA-----REAMEH 321 Query: 598 AFFRYIDWEK 607 +F + ++ Sbjct: 322 PYFYTVVKDQ 331 >3LLT-A nrPDB Length = 360 Score = 171 bits (434), Expect = 7e-43, Method: Composition-based stats. Identities = 58/254 (22%), Positives = 97/254 (38%), Gaps = 31/254 (12%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 F + +G G+FG+V+L + + YAVK+++ + K++ Sbjct: 37 FLVIRKMGDGTFGRVLLCQHIDNKKYYAVKVVRNIKKYTRSAKIEADILKKIQNDDINNN 96 Query: 402 FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR--FKEPHAVFYAAEIAIGLFFLQS 459 + + H F D + + E + G L I + F Y EI L +L+ Sbjct: 97 NIVKYHGKFMYYDHMCLIFEPL-GPSLYEIITRNNYNGFHIEDIKLYCIEILKALNYLRK 155 Query: 460 KGIIYRDLKLDNVMLD--------------SEGH-----------IKIADFGMCKENIWD 494 + + DLK +N++LD ++G IK+ DFG + Sbjct: 156 MSLTHTDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRTKSTGIKLIDFGCA---TFK 212 Query: 495 GVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIM 554 + T Y APE+I + S D W+FG +L E+ G F + E + Sbjct: 213 SDYHGSIINTRQYRAPEVILNLGWDVSSDMWSFGCVLAELYTGSLLFRTHEHMEHLAMME 272 Query: 555 EHNVAYPKSMSKEA 568 PK+M EA Sbjct: 273 SIIQPIPKNMLYEA 286 >5IKW-A nrPDB Length = 310 Score = 170 bits (431), Expect = 2e-42, Method: Composition-based stats. Identities = 59/280 (21%), Positives = 103/280 (36%), Gaps = 39/280 (13%) Query: 343 NFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPF 402 L +G F V L G A+K + + + D+ E ++ Sbjct: 17 TLEESLAEGGFSTVFLVRTHG-GIRCALKRMYVNNMP---DLNVCKREITIMKELSGHKN 72 Query: 403 LTQLHSCFQTM--DRLY---FVMEYVNGGDLMYHIQQV--GRFKEPHAVFYAAEIAIGLF 455 + C D ++ +MEY G ++ + + F EP + + + Sbjct: 73 IVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVA 132 Query: 456 FLQSKG--IIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCG--------TP 505 L II+RDLK++N++L+ G+ + DFG + T Sbjct: 133 RLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTL 192 Query: 506 DYIAPEIIA---YQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPK 562 Y APE+I +P D WA G LLY++ PF GE + +I + N P Sbjct: 193 SYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPF-GESQV----AICDGNFTIPD 247 Query: 563 S--MSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFF 600 + S+ + + ++ P R DI + ++F Sbjct: 248 NSRYSRNIHCLIRFMLEPDPEHR--------PDIFQVSYF 279 >3MDY-A nrPDB Length = 337 Score = 170 bits (431), Expect = 2e-42, Method: Composition-based stats. Identities = 57/287 (19%), Positives = 105/287 (36%), Gaps = 48/287 (16%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 + +GKG +G+V + + + E AVK+ E + + ++ Sbjct: 39 IQMVKQIGKGRYGEVWMGKWR--GEKVAVKVFFTTEEASW-FRETEIYQTVLMRHENILG 95 Query: 402 FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSK- 460 F+ + +LY + +Y G L +++ + A GL L ++ Sbjct: 96 FIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTT-LDAKSMLKLAYSSVSGLCHLHTEI 154 Query: 461 -------GIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWD----GVTTKTFCGTPDYIA 509 I +RDLK N+++ G IAD G+ + I D + T GT Y+ Sbjct: 155 FSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMP 214 Query: 510 PEII-------AYQPYGKSVDWWAFGVLLYEMLAG----------QAPFEG--------E 544 PE++ +Q Y D ++FG++L+E+ Q P+ E Sbjct: 215 PEVLDESLNRNHFQSY-IMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDPSYE 273 Query: 545 DEDELFQSIMEHNVAYPKSMSKE-----AVAICKGLMTKHPGKRLGC 586 D E+ I + ++P S + + +P RL Sbjct: 274 DMREIV-CIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTA 319 >2BUJ-A nrPDB Length = 317 Score = 170 bits (431), Expect = 2e-42, Method: Composition-based stats. Identities = 62/271 (22%), Positives = 109/271 (40%), Gaps = 37/271 (13%) Query: 341 DFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKP 400 + F+ LG+G F V L E YA+K + + + D E E + L P Sbjct: 30 HYLFIQKLGEGGFSYVDLVEGLHDGHFYALKRI---LCHEQQDREEAQREADMHRLFNHP 86 Query: 401 PFLTQLHSCFQT---MDRLYFVMEYVNGGDLMYHIQQVGR----FKEPHAVFYAAEIAIG 453 L + C + + ++ + G L I+++ E ++ I G Sbjct: 87 NILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFLTEDQILWLLLGICRG 146 Query: 454 LFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGM----------CKENIWDGVTTKTFCG 503 L + +KG +RDLK N++L EG + D G ++ + C Sbjct: 147 LEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSRQALTLQDWAAQRC- 205 Query: 504 TPDYIAPEIIAYQPY---GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQS------IM 554 T Y APE+ + Q + + D W+ G +LY M+ G+ P+ D +FQ + Sbjct: 206 TISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPY-----DMVFQKGDSVALAV 260 Query: 555 EHNVAYPKS--MSKEAVAICKGLMTKHPGKR 583 ++ ++ P+S S + +MT P +R Sbjct: 261 QNQLSIPQSPRHSSALWQLLNSMMTVDPHQR 291 >6HMD-A nrPDB Length = 365 Score = 169 bits (429), Expect = 3e-42, Method: Composition-based stats. Identities = 60/303 (19%), Positives = 115/303 (37%), Gaps = 57/303 (18%) Query: 340 TDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK 399 D+ + LG+G + +V + +E +++ + E ++L Sbjct: 53 DDYQLVRKLGRGKYSEVFEAINITNNER------VVVKILKPVKKKKIKREVKILENLRG 106 Query: 400 PPFLTQLHSCFQTM--DRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFL 457 + +L + V EY+N D Q + F FY E+ L + Sbjct: 107 GTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFD---IRFYMYELLKALDYC 163 Query: 458 QSKGIIYRDLKLDNVMLDS-EGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEII-AY 515 SKGI++RD+K NVM+D + +++ D+G+ E + + PE++ Y Sbjct: 164 HSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLA-EFYHPAQEYNVRVASRYFKGPELLVDY 222 Query: 516 QPYGKSVDWWAFGVLLYEMLAGQAP-FEGEDE-------------DELFQSIMEHNVAYP 561 Q Y S+D W+ G +L M+ + P F G+D +EL+ + ++++ Sbjct: 223 QMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLD 282 Query: 562 KS------------------------MSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEH 597 +S EA+ + L+ +RL ++ EH Sbjct: 283 PHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTA-----KEAMEH 337 Query: 598 AFF 600 +F Sbjct: 338 PYF 340 >6EII-A nrPDB Length = 352 Score = 169 bits (428), Expect = 4e-42, Method: Composition-based stats. Identities = 64/306 (20%), Positives = 112/306 (36%), Gaps = 57/306 (18%) Query: 340 TDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK 399 D+ + LG+G + +V + +E +++ + E ++L Sbjct: 60 DDYQLVRKLGRGKYSEVFEAINITNNEK------VVVKILKPVKKKKIKREIKILENLRG 113 Query: 400 PPFLTQLHSCFQTM--DRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFL 457 P + L + V E+VN D Q + FY EI L + Sbjct: 114 GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYC 170 Query: 458 QSKGIIYRDLKLDNVMLDSEGH-IKIADFGMCKENIWDGVTTKTFCGTPDYIAPEII-AY 515 S GI++RD+K NVM+D E +++ D+G+ E G + + PE++ Y Sbjct: 171 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLVDY 229 Query: 516 QPYGKSVDWWAFGVLLYEMLAGQAPF-EGEDE-------------DELFQSIMEHNVAYP 561 Q Y S+D W+ G +L M+ + PF G D ++L+ I ++N+ Sbjct: 230 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 289 Query: 562 KS------------------------MSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEH 597 +S EA+ L+ RL R+ EH Sbjct: 290 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTA-----REAMEH 344 Query: 598 AFFRYI 603 +F + Sbjct: 345 PYFYTV 350 >2PVN-A nrPDB Length = 352 Score = 168 bits (427), Expect = 4e-42, Method: Composition-based stats. Identities = 55/306 (17%), Positives = 106/306 (34%), Gaps = 57/306 (18%) Query: 340 TDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK 399 D+ + +G+G + +V +E +++ + E ++L Sbjct: 52 DDYEVVRKVGRGKYSEVFEGINVNNNEKC------IIKILKPVKKKKIKREIKILQNLCG 105 Query: 400 PPFLTQLHSCF--QTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFL 457 P + +L Q + EYVN D + +Y E+ L + Sbjct: 106 GPNIVKLLDIVRDQHSKTPSLIFEYVNNTDFKVL---YPTLTDYDIRYYIYELLKALDYC 162 Query: 458 QSKGIIYRDLKLDNVMLDSEGH-IKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAY- 515 S+GI++RD+K NVM+D E +++ D+G+ E G + + PE++ Sbjct: 163 HSQGIMHRDVKPHNVMIDHELRKLRLIDWGLA-EFYHPGKEYNVRVASRYFKGPELLVDL 221 Query: 516 QPYGKSVDWWAFGVLLYEMLAGQAP-FEGEDEDELFQSIM-------------EHNVAYP 561 Q Y S+D W+ G + M+ + P F G D + I ++ + Sbjct: 222 QDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKIAKVLGTDGLNAYLNKYRIELD 281 Query: 562 KS------------------------MSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEH 597 +S EA+ L+ +RL + H Sbjct: 282 PQLEALVGRHSRKPWLKFMNADNQHLVSPEAIDFLDKLLRYDHQERLTAL-----EAMTH 336 Query: 598 AFFRYI 603 +F+ + Sbjct: 337 PYFQQV 342 >2QKW-B nrPDB Length = 321 Score = 168 bits (425), Expect = 9e-42, Method: Composition-based stats. Identities = 49/203 (24%), Positives = 81/203 (39%), Gaps = 11/203 (5%) Query: 340 TDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK 399 +F+ ++G G FGKV + A+K + + + Sbjct: 39 NNFDHKFLIGHGVFGKVYKGVLR-DGAKVALK----RRTPESSQGIEEFETEIETLSFCR 93 Query: 400 PPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVG----RFKEPHAVFYAAEIAIGLF 455 P L L + + + +Y+ G+L H+ + A GL Sbjct: 94 HPHLVSLIGFCDERNEMILIYKYMENGNLKRHLYGSDLPTMSMSWEQRLEICIGAARGLH 153 Query: 456 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIW-DGVTTKTFC-GTPDYIAPEII 513 +L ++ II+RD+K N++LD KI DFG+ K+ D T GT YI PE Sbjct: 154 YLHTRAIIHRDVKSINILLDENFVPKITDFGISKKGTELDQTHLSTVVKGTLGYIDPEYF 213 Query: 514 AYQPYGKSVDWWAFGVLLYEMLA 536 + D ++FGV+L+E+L Sbjct: 214 IKGRLTEKSDVYSFGVVLFEVLC 236 >3MY0-A nrPDB Length = 305 Score = 167 bits (422), Expect = 2e-41, Method: Composition-based stats. Identities = 58/288 (20%), Positives = 98/288 (34%), Gaps = 54/288 (18%) Query: 344 FLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRV-----LALPG 398 + +GKG +G+V E AVKI D + E + L Sbjct: 12 LVECVGKGRYGEVWRGLWH--GESVAVKI------FSSRDEQSWFRETEIYNTVLLRHDN 63 Query: 399 KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQ 458 F+ + + +L+ + Y G L +Q+ + A+ A A GL L Sbjct: 64 ILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQT-LEPHLALRLAVSAACGLAHLH 122 Query: 459 --------SKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTT----KTFCGTPD 506 I +RD K NV++ S IAD G+ + GT Sbjct: 123 VEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKR 182 Query: 507 YIAPEIIAYQPYG------KSVDWWAFGVLLYEMLAG----------QAPFEG----EDE 546 Y+APE++ Q K D WAFG++L+E+ + PF + Sbjct: 183 YMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPS 242 Query: 547 DELFQSIM---EHNVAYPKSMSKE-----AVAICKGLMTKHPGKRLGC 586 E + ++ + P ++ + + + +P RL Sbjct: 243 FEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTA 290 >5XVU-A nrPDB Length = 332 Score = 165 bits (418), Expect = 6e-41, Method: Composition-based stats. Identities = 56/308 (18%), Positives = 109/308 (35%), Gaps = 57/308 (18%) Query: 338 KLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALP 397 K + + +G+G + +V + A V++ + E ++L Sbjct: 29 KPNRYEIMKKIGRGKYSEVFNGYDTECNRPCA------IKVLKPVKKKKIKREIKILQNL 82 Query: 398 GKPPFLTQLHSCFQTM--DRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 455 P + +L + + EY+N D +F + +Y +I L Sbjct: 83 NGGPNIIKLLDIVKDPVTKTPSLIFEYINNIDFKTL---YPKFTDKDIRYYIYQILKALD 139 Query: 456 FLQSKGIIYRDLKLDNVMLDSEGH-IKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA 514 + S+GI++RD+K N+M+D E I++ +G+ E G + Y PE++ Sbjct: 140 YCHSQGIMHRDVKPHNIMIDHENRQIRLISWGLA-EFYHPGQEYNVRVASRYYKGPELLI 198 Query: 515 Y-QPYGKSVDWWAFGVLLYEMLAGQAP-FEGEDEDELFQSIME-----------HNVAY- 560 Q Y S+D W+ G +L M+ + P F G D + I + Sbjct: 199 DLQLYDYSLDIWSLGCMLAGMIFKKEPFFCGHDNYDQLVKIAKVLGTEDLHAYLKKYNIK 258 Query: 561 --PKSMS-----------------------KEAVAICKGLMTKHPGKRLGCGPEGERDIK 595 P ++ E + + ++ KR+ ++ Sbjct: 259 LKPHYLNILGEYERKPWSHFLTQSNIDIAKDEVIDLIDKMLIYDHAKRI-----APKEAM 313 Query: 596 EHAFFRYI 603 EH +FR + Sbjct: 314 EHPYFREV 321 >3REP-A nrPDB Length = 271 Score = 165 bits (417), Expect = 7e-41, Method: Composition-based stats. Identities = 52/258 (20%), Positives = 100/258 (38%), Gaps = 20/258 (7%) Query: 337 MKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLAL 396 + NFL L + G++ +G D + V ++ + D R+ + Sbjct: 7 IDFKQLNFLTKLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRDFNEECPRLRIFS- 65 Query: 397 PGKPPFLTQLHSCFQTMD--RLYFVMEYVNGGDLMYHIQQVGRF--KEPHAVFYAAEIAI 452 P + + Q+ + ++ G L + + F + AV +A ++A Sbjct: 66 ---HPNVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMAR 122 Query: 453 GLFFLQS-KGIIYRD-LKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAP 510 G+ FL + + +I R L +VM+D + +I ++ + P ++AP Sbjct: 123 GMAFLHTLEPLIPRHALNSRSVMIDEDMTARI-----SMADVKFSFQSPGRMYAPAWVAP 177 Query: 511 EIIAYQPYGK---SVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEH--NVAYPKSMS 565 E + +P S D W+F VLL+E++ + PF E+ + P +S Sbjct: 178 EALQKKPEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPTIPPGIS 237 Query: 566 KEAVAICKGLMTKHPGKR 583 + K M + P KR Sbjct: 238 PHVSKLMKICMNEDPAKR 255 >5VC6-A nrPDB Length = 289 Score = 161 bits (408), Expect = 8e-40, Method: Composition-based stats. Identities = 56/282 (19%), Positives = 106/282 (37%), Gaps = 35/282 (12%) Query: 340 TDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK 399 T+F+ L +G G FG V ++ +YA+K KK + D+ + + E A+ G+ Sbjct: 11 TEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDE-QNALREVYAHAVLGQ 69 Query: 400 PPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR----FKEPHAVFYAAEIAIGLF 455 + + S + D + EY NGG L I + R FKE ++ GL Sbjct: 70 HSHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLR 129 Query: 456 FLQSKGIIYRDLKLDNVMLD-----------------SEGHI--KIADFGMCKENIWDGV 496 ++ S +++ D+K N+ + + + KI D G V Sbjct: 130 YIHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQV 189 Query: 497 TTKTFCGTPDYIAPEIIAYQPYGK--SVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIM 554 ++A E++ Y D +A + + AG P + + I Sbjct: 190 EEGDS----RFLANEVLQEN-YTHLPKADIFALALTV-VCAAGAEPLP--RNGDQWHEIR 241 Query: 555 EHNV-AYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIK 595 + + P+ +S+E + K ++ P +R + + Sbjct: 242 QGRLPRIPQVLSQEFTELLKVMIHPDPERRPSAMALVKHSVL 283 >5XD6-A nrPDB Length = 305 Score = 160 bits (406), Expect = 1e-39, Method: Composition-based stats. Identities = 50/215 (23%), Positives = 87/215 (40%), Gaps = 20/215 (9%) Query: 340 TDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK 399 ++ ++G+GS+G+V K + + A+K L + + + +++ + Sbjct: 22 DNYGSKSLIGEGSYGRVFYGILK-SGKAAAIKKLDSSKQPD----QEFLAQVSMVSRLRQ 76 Query: 400 PPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVG---------RFKEPHAVFYAAEI 450 + L C R+ EY G L + V A Sbjct: 77 ENVVALLGYCVDGPLRV-LAYEYAPNGSLHDILHGRKGVKGAQPGPVLSWHQRVKIAVGA 135 Query: 451 AIGLFFLQSK---GIIYRDLKLDNVMLDSEGHIKIADFGMCKE--NIWDGVTTKTFCGTP 505 A GL +L K +I+RD+K NV+L + KIADF + + ++ + + GT Sbjct: 136 ARGLEYLHEKANPHVIHRDIKSSNVLLFDDDVAKIADFDLSNQAPDMAARLHSTRVLGTF 195 Query: 506 DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAP 540 Y APE D ++FGV+L E+L G+ P Sbjct: 196 GYHAPEYAMTGTLSTKSDVYSFGVVLLELLTGRKP 230 >6BFN-A nrPDB Length = 342 Score = 160 bits (404), Expect = 2e-39, Method: Composition-based stats. Identities = 53/214 (24%), Positives = 90/214 (42%), Gaps = 19/214 (8%) Query: 341 DFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVEC-TMVEKRVLALPGK 399 +F+ + +G+G FG V + + T +YAVK LK++ ++ V+ + E L+ + Sbjct: 23 NFSEELKIGEGGFGCVYRAVMRNT--VYAVKRLKENADLEWTAVKQSFLTEVEQLSRF-R 79 Query: 400 PPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQ----QVGRFKEPHAVFYAAEIAIGLF 455 P + V ++ G L + P + A + Sbjct: 80 HPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQ 139 Query: 456 FLQ--SKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGV---------TTKTFCGT 504 FL S +I+ D+K NV+LD K+ DFG+ + + + G T+T GT Sbjct: 140 FLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGT 199 Query: 505 PDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQ 538 Y+ E I D ++FGV++ E LAGQ Sbjct: 200 LAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQ 233 >3HNG-A nrPDB Length = 360 Score = 159 bits (403), Expect = 3e-39, Method: Composition-based stats. Identities = 43/154 (27%), Positives = 72/154 (46%), Gaps = 5/154 (3%) Query: 435 VGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIW- 493 + Y+ ++A G+ FL S+ I+RDL N++L +KI DFG+ ++ Sbjct: 193 KEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKN 252 Query: 494 DGVTTKTFCGTP-DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQ 551 K P ++APE I + Y D W++GVLL+E+ + G +P+ G DE F Sbjct: 253 PDYVRKGDTRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFC 312 Query: 552 SIMEHNVAY--PKSMSKEAVAICKGLMTKHPGKR 583 S + + P+ + E I + P +R Sbjct: 313 SRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKER 346 Score = 83.9 bits (206), Expect = 2e-16, Method: Composition-based stats. Identities = 23/118 (19%), Positives = 46/118 (38%), Gaps = 8/118 (6%) Query: 327 KFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLS-----ERKGTDELYAVKILKKDVVIQD 381 + + ++ LG+G+FGKV+ + ++ T AVK+LK+ + Sbjct: 14 RLPYDASKWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATASE 73 Query: 382 DDVECTMVEKRVLALPGKPPFLTQLHSCFQT-MDRLYFVMEYVNGGDLMYHIQQVGRF 438 + M E ++L G + L L ++EY G+L +++ Sbjct: 74 --YKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKRDL 129 >2JD5-A nrPDB Length = 373 Score = 159 bits (402), Expect = 4e-39, Method: Composition-based stats. Identities = 65/335 (19%), Positives = 118/335 (35%), Gaps = 76/335 (22%) Query: 335 DRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVL 394 + K + + LG G F V L++ + A+KI++ D V + + + +RV Sbjct: 14 EPYKDARYILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVRGDKVYTEAAEDEIKLLQRVN 73 Query: 395 ALPGKP------PFLTQLHSCFQTMD----RLYFVMEYVNGGDLMYHIQQVGRFKEPHA- 443 + +L F + V E V G +L+ I++ P Sbjct: 74 DADNTKEDSMGANHILKLLDHFNHKGPNGVHVVMVFE-VLGENLLALIKKYEHRGIPLIY 132 Query: 444 -VFYAAEIAIGLFFLQSK-GIIYRDLKLDNVM---LDSEG---HIKIADFGMCKENIWDG 495 + ++ +GL ++ + GII+ D+K +NV+ +DS IKIAD G W Sbjct: 133 VKQISKQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNA---CWYD 189 Query: 496 VTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPF-------EGEDEDE 548 T +Y +PE++ P+G D W+ L++E++ G F +D+D Sbjct: 190 EHYTNSIQTREYRSPEVLLGAPWGCGADIWSTACLIFELITGDFLFEPDEGHSYTKDDDH 249 Query: 549 LFQSI-----------------------------------------MEHNVAYPKSMSKE 567 + Q I + + K +KE Sbjct: 250 IAQIIELLGELPSYLLRNGKYTRTFFNSRGLLRNISKLKFWPLEDVLTEKYKFSKDEAKE 309 Query: 568 AVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRY 602 ++ P KR G + H + + Sbjct: 310 ISDFLSPMLQLDPRKRADAGG-----LVNHPWLKD 339 >3VHK-A nrPDB Length = 368 Score = 158 bits (400), Expect = 6e-39, Method: Composition-based stats. Identities = 47/165 (28%), Positives = 77/165 (46%), Gaps = 10/165 (6%) Query: 438 FKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWD-GV 496 H + Y+ ++A G+ FL S+ I+RDL N++L + +KI DFG+ ++ D Sbjct: 197 LTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDY 256 Query: 497 TTKTFCGTP-DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELF-QSI 553 K P ++APE I + Y D W+FGVLL+E+ + G +P+ G DE F + + Sbjct: 257 VRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRL 316 Query: 554 MEH-NVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEH 597 E + P + E P +R ++ EH Sbjct: 317 KEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPT-----FSELVEH 356 Score = 80.4 bits (197), Expect = 2e-15, Method: Composition-based stats. Identities = 21/117 (17%), Positives = 45/117 (38%), Gaps = 8/117 (6%) Query: 327 KFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSE-----RKGTDELYAVKILKKDVVIQD 381 + + ++ LG+G+FG+V+ ++ + T AVK+LK+ + Sbjct: 16 RLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSE 75 Query: 382 DDVECTMVEKRVLALPGKPPFLTQLHSCFQTMD-RLYFVMEYVNGGDLMYHIQQVGR 437 M E ++L G + L L ++E+ G+L +++ Sbjct: 76 H--RALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRN 130 >1PY5-A nrPDB Length = 326 Score = 158 bits (399), Expect = 9e-39, Method: Composition-based stats. Identities = 57/288 (19%), Positives = 99/288 (34%), Gaps = 54/288 (18%) Query: 344 FLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA-LPGKPPF 402 +GKG FG+V + + E AVKI + E + + + Sbjct: 33 LQESIGKGRFGEVWRGKWR--GEEVAVKI------FSSREERSWFREAEIYQTVMLRHEN 84 Query: 403 LTQLHSCFQTMD----RLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQ 458 + + + +L+ V +Y G L ++ + + A A GL L Sbjct: 85 ILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYT-VTVEGMIKLALSTASGLAHLH 143 Query: 459 --------SKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVT----TKTFCGTPD 506 I +RDLK N+++ G IAD G+ + T GT Sbjct: 144 MEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKR 203 Query: 507 YIAPEI----IAYQPYG--KSVDWWAFGVLLYEMLAG----------QAPFE-----GED 545 Y+APE+ I + + K D +A G++ +E+ Q P+ Sbjct: 204 YMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPS 263 Query: 546 EDELFQSIMEHNVA--YP-KSMSKEA----VAICKGLMTKHPGKRLGC 586 +E+ + + E + P + S EA I + + RL Sbjct: 264 VEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTA 311 >5VDK-A nrPDB Length = 297 Score = 157 bits (396), Expect = 2e-38, Method: Composition-based stats. Identities = 51/285 (17%), Positives = 102/285 (35%), Gaps = 37/285 (12%) Query: 341 DFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKP 400 +F + +G G FG V ++ +YA+K + + + E A+ G Sbjct: 16 EFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKR-SMKTFTELSNENSALHEVYAHAVLGHH 74 Query: 401 PFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHI----QQVGRFKEPHAVFYAAEIAIGLFF 456 P + + +S + D + EY NGG L I + F+EP +I++GL + Sbjct: 75 PHVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQISLGLNY 134 Query: 457 LQSKGIIYRDLKLDNVML------DSEGHI-----------------KIADFGMCKENIW 493 + + +++ D+K N+ + +S G I KI D G Sbjct: 135 IHNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIGDLGHATSINK 194 Query: 494 DGVTTKTFCGTPDYIAPEIIAYQ-PYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQS 552 V ++A EI+ + D +A G+ + ++ + Sbjct: 195 PKVEEGDS----RFLANEILQEDYRHLPKADIFALGLTIAVAAGAESL---PTNGAAWHH 247 Query: 553 IMEHNV-AYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKE 596 I + N P+ +S+ ++ K ++ +R + Sbjct: 248 IRKGNFPDVPQELSESFSSLLKNMIQPDAEQRPSAAALARNTVLR 292 >4PL5-B nrPDB Length = 435 Score = 157 bits (396), Expect = 2e-38, Method: Composition-based stats. Identities = 59/275 (21%), Positives = 107/275 (38%), Gaps = 35/275 (12%) Query: 345 LMVLGKGSFGK-VMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFL 403 VLG G+ G V + AVK + + D E ++L + P + Sbjct: 32 KDVLGHGAEGTIVYKGMF--DNRDVAVKRILPECFSFAD------REVQLLRESDEHPNV 83 Query: 404 TQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKE-PHAVFYAAEIAIGLFFLQSKGI 462 + + Y +E L +++Q + + GL L S I Sbjct: 84 IRYFCTEKDRQFQYIAIELCAA-TLQEYVEQKDFAHLGLEPITLLHQTTSGLAHLHSLNI 142 Query: 463 IYRDLKLDNVML---DSEGHIK--IADFGMCKENI---WDGVTTKTFCGTPDYIAPEIIA 514 ++RDLK N++L ++ G IK I+DFG+CK+ GT +IAPE+++ Sbjct: 143 VHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLS 202 Query: 515 ---YQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIMEHNVAYPKSMSKE--- 567 +VD ++ G + Y +++ G PF G+ +I+ S + Sbjct: 203 EDCKDNPTYTVDIFSAGCVFYYVISEGYHPF-GKSLQRQ-ANILLGACNLDCFHSDKHED 260 Query: 568 --AVAICKGLMTKHPGKRLGCGPEGERDIKEHAFF 600 A + + ++ P +R + + +H FF Sbjct: 261 VIARELIEKMIAMDPQQRPSA-----KHVLKHPFF 290 >4M66-A nrPDB Length = 325 Score = 157 bits (396), Expect = 2e-38, Method: Composition-based stats. Identities = 58/269 (21%), Positives = 103/269 (38%), Gaps = 25/269 (9%) Query: 337 MKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLAL 396 + + L +GKG FG V + + + AVKI+ + + + + VL L Sbjct: 17 VSREELKKLEFVGKGGFGVVFRAHHRTWNHDVAVKIVNSKKISWEVKAMVNLRNENVLLL 76 Query: 397 PGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFF 456 G L Q V ++ G L +Q P E+ +G+ + Sbjct: 77 LGVTEDLQWDFVSGQA-----LVTRFMENGSLAGLLQPEAPRPWPLLCRLLQEVVLGMCY 131 Query: 457 LQS--KGIIYRDLKLDNVMLDSEGHIKIADFGMCK------ENIWDGVTTKTFCGTPDYI 508 L S +++RDLK N++LD E H K+ADFG+ G ++ GT Y+ Sbjct: 132 LHSLDPPLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQSGSGSGSGSRDSGGTLAYL 191 Query: 509 APEIIAY--QPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYP----K 562 PE++ K+ D ++FG+L++ +LAG+ + + +++ + P Sbjct: 192 DPELLFKVNLKASKASDVYSFGILVWAVLAGREAELVDKTSLIRETVCDRQSRPPLTELP 251 Query: 563 SMSKE------AVAICKGLMTKHPGKRLG 585 S E + R Sbjct: 252 PGSPETPGLEKLKELMIHCWGSQSENRPS 280 >2Y4I-B nrPDB Length = 319 Score = 156 bits (394), Expect = 3e-38, Method: Composition-based stats. Identities = 55/265 (20%), Positives = 99/265 (37%), Gaps = 25/265 (9%) Query: 339 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 398 ++GKG FG+V G A++++ D+ ++D + + Sbjct: 32 FEQLEIGELIGKGRFGQVYHGRWHG---EVAIRLI--DIERDNEDQLKAFKREVMAYRQT 86 Query: 399 KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVG-RFKEPHAVFYAAEIAIGLFFL 457 + + + L + G L ++ A EI G+ +L Sbjct: 87 RHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYL 146 Query: 458 QSKGIIYRDLKLDNVMLDSEGHIKIADFGMCK-----ENIWDGVTTKTFCGTPDYIAPEI 512 +KGI+++DLK NV D G + I DFG+ + + G ++APEI Sbjct: 147 HAKGILHKDLKSKNVFYD-NGKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAPEI 205 Query: 513 IAY---------QPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSI---MEHNVAY 560 I P+ K D +A G + YE+ A + PF+ + + + + M+ N++ Sbjct: 206 IRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGTGMKPNLSQ 265 Query: 561 PKSMSKEAVAICKGLMTKHPGKRLG 585 M KE I +R Sbjct: 266 I-GMGKEISDILLFCWAFEQEERPT 289 >6HV0-A nrPDB Length = 416 Score = 155 bits (392), Expect = 6e-38, Method: Composition-based stats. Identities = 58/275 (21%), Positives = 109/275 (39%), Gaps = 35/275 (12%) Query: 345 LMVLGKGSFGK-VMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFL 403 VLG G+ G V + AVK + + D E ++L + P + Sbjct: 13 KDVLGHGAEGTIVYRGMF--DNRDVAVKRILPECFSFAD------REVQLLRESDEHPNV 64 Query: 404 TQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKE-PHAVFYAAEIAIGLFFLQSKGI 462 + + Y +E L +++Q + + GL L S I Sbjct: 65 IRYFCTEKDRQFQYIAIELCAA-TLQEYVEQKDFAHLGLEPITLLQQTTSGLAHLHSLNI 123 Query: 463 IYRDLKLDNVML---DSEGHIK--IADFGMCKENI---WDGVTTKTFCGTPDYIAPEIIA 514 ++RDLK N+++ ++ G IK I+DFG+CK+ GT +IAPE+++ Sbjct: 124 VHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLS 183 Query: 515 ---YQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIMEHNVAYPKSMSKE--- 567 + +VD ++ G + Y +++ G PF G+ +I+ + ++ Sbjct: 184 EDCKENPTYTVDIFSAGCVFYYVISEGSHPF-GKSLQRQ-ANILLGACSLDCLHPEKHED 241 Query: 568 --AVAICKGLMTKHPGKRLGCGPEGERDIKEHAFF 600 A + + ++ P KR + + +H FF Sbjct: 242 VIARELIEKMIAMDPQKRPSA-----KHVLKHPFF 271 >4CRL-A nrPDB Length = 406 Score = 155 bits (392), Expect = 6e-38, Method: Composition-based stats. Identities = 63/351 (17%), Positives = 122/351 (34%), Gaps = 82/351 (23%) Query: 319 EKTANTISKFDNNGNRDRMK-LTDFNFLMVLGKGSFGKVMLSERKGTDEL--YAVKILKK 375 + + K + R+R++ L ++ V G+G++G V ++RK + YA+K + Sbjct: 1 DDKMDYDFKVKLSSERERVEDLFEYEGCKV-GRGTYGHVYKAKRKDGKDDKDYALKQI-- 57 Query: 376 DVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCF--QTMDRLYFVMEYVNGGDLMYHIQ 433 + + + + L K P + L F +++ + +Y DL + I+ Sbjct: 58 ----EGTGISMSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEH-DLWHIIK 112 Query: 434 ---------QVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLD----SEGHI 480 + + +I G+ +L + +++RDLK N+++ G + Sbjct: 113 FHRASKANKKPVQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRV 172 Query: 481 KIADFGMCKENIWDGVT---TKTFCGTPDYIAPEIIAY-QPYGKSVDWWAFGVLLYEMLA 536 KIAD G + T Y APE++ + Y K++D WA G + E+L Sbjct: 173 KIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLT 232 Query: 537 GQAPFEGEDED---------ELFQSIM-----------EHNVAYPKS------------- 563 + F ED + I E P+ Sbjct: 233 SEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYT 292 Query: 564 --------------MSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFF 600 +A + + L+T P KR+ + +F Sbjct: 293 NCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKRIT-----SEQAMQDPYF 338 >3G2F-A nrPDB Length = 336 Score = 151 bits (382), Expect = 7e-37, Method: Composition-based stats. Identities = 56/326 (17%), Positives = 111/326 (34%), Gaps = 67/326 (20%) Query: 328 FDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECT 387 + + + L + L ++G+G +G V + AVK+ + + Sbjct: 1 MEAAASEPSLDLDNLKLLELIGRGRYGAVYKG--SLDERPVAVKV------FSFANRQNF 52 Query: 388 MVEKRV-----LALPGKPPFLTQLHSCFQTMDRLYF-VMEYVNGGDLMYHIQQVGRFKEP 441 + EK + + F+ Y VMEY G L ++ Sbjct: 53 INEKNIYRVPLMEHDNIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTS-DWV 111 Query: 442 HAVFYAAEIAIGLFFLQSK---------GIIYRDLKLDNVMLDSEGHIKIADFGMCKENI 492 + A + GL +L ++ I +RDL NV++ ++G I+DFG+ Sbjct: 112 SSCRLAHSVTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLT 171 Query: 493 WDGVTTK--------TFCGTPDYIAPEIIAY-------QPYGKSVDWWAFGVLLYEMLAG 537 + + + GT Y+APE++ + K VD +A G++ +E+ Sbjct: 172 GNRLVRPGEEDNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMR 231 Query: 538 QA-PFEGED-------------------EDELFQSIMEHNVAYPKSM---SKEAVAI--- 571 F GE + ++ S + +P++ S ++ Sbjct: 232 CTDLFPGESVPEYQMAFQTEVGNHPTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKET 291 Query: 572 CKGLMTKHPGKRLG--CGPEGERDIK 595 + + RL C E ++ Sbjct: 292 IEDCWDQDAEARLTAQCAEERMAELM 317 >4RT7-A nrPDB Length = 415 Score = 151 bits (381), Expect = 1e-36, Method: Composition-based stats. Identities = 47/203 (23%), Positives = 90/203 (44%), Gaps = 14/203 (6%) Query: 389 VEKRVLALPGKPPFLTQLHS-CFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYA 447 E ++ + ++ LH F + D + EY N L + + + +A Sbjct: 198 REVQIHPDSDQ---ISGLHGNSFHSEDEI----EYENQKRLEEE-EDLNVLTFEDLLCFA 249 Query: 448 AEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDG-VTTKTFCGTP- 505 ++A G+ FL+ K ++RDL NV++ +KI DFG+ ++ + D + P Sbjct: 250 YQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPV 309 Query: 506 DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIMEH--NVAYPK 562 ++APE + Y D W++G+LL+E+ + G P+ G D F ++++ + P Sbjct: 310 KWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPF 369 Query: 563 SMSKEAVAICKGLMTKHPGKRLG 585 ++E I + KR Sbjct: 370 YATEEIYIIMQSCWAFDSRKRPS 392 Score = 96.6 bits (239), Expect = 3e-20, Method: Composition-based stats. Identities = 27/108 (25%), Positives = 45/108 (41%), Gaps = 7/108 (6%) Query: 334 RDRMKLTDFNFLMVLGKGSFGKVMLSE-----RKGTDELYAVKILKKDVVIQDDDVECTM 388 + + F VLG G+FGKVM + + G AVK+LK+ + E M Sbjct: 59 KWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKA--DSSEREALM 116 Query: 389 VEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVG 436 E +++ G + L +Y + EY GDL+ +++ Sbjct: 117 SELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKR 164 >5W5C-F nrPDB Length = 282 Score = 150 bits (378), Expect = 3e-36, Method: Composition-based stats. Identities = 42/132 (31%), Positives = 70/132 (53%), Gaps = 6/132 (4%) Query: 157 ERRGRIYIQAHID--REVLIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKT 214 E+ G++ D L+V + A L +D G SDPYVK+ L+PD K K +TK Sbjct: 1 EKLGKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLLPDKKK--KFETKV 58 Query: 215 IKCSLNPEWNETFRFQLKESDK-DRRLSVEIWDWDLTSRNDFMGSLSFGISELQKAGV-D 272 + +LNP +NE F F++ S+ + L + ++D+D S++D +G ++ + V + Sbjct: 59 HRKTLNPVFNEQFTFKVPYSELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNTVDFGHVTE 118 Query: 273 GWFKLLSQEEGE 284 W L S E+ E Sbjct: 119 EWRDLQSAEKEE 130 Score = 112 bits (280), Expect = 6e-25, Method: Composition-based stats. Identities = 44/127 (34%), Positives = 68/127 (53%), Gaps = 4/127 (3%) Query: 157 ERRGRIYIQAHI--DREVLIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKT 214 E+ G I L VV+ +AKNL MD GLSDPYVK+ L+ + K K+KT Sbjct: 132 EKLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTI 191 Query: 215 IKCSLNPEWNETFRFQLK-ESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKAGVDG 273 K +LNP +NE+F F++ E + ++ V + D+D +ND +G + G + A + Sbjct: 192 KKNTLNPYYNESFSFEVPFEQIQKVQVVVTVLDYDKIGKNDAIGKVFVGYNSTG-AELRH 250 Query: 274 WFKLLSQ 280 W +L+ Sbjct: 251 WSDMLAN 257 >4LFI-A nrPDB Length = 374 Score = 149 bits (377), Expect = 3e-36, Method: Composition-based stats. Identities = 56/352 (15%), Positives = 110/352 (31%), Gaps = 85/352 (24%) Query: 327 KFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAV---------------- 370 ++N D+ +G+G + +V + + + Sbjct: 27 DYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIK 86 Query: 371 --------KILKKDVVIQDDDVECTMVEKRVLAL---------PGKPPFLTQLHSCFQTM 413 K+ + Q D E VL + L + Sbjct: 87 ILTDLSNEKVPPTTLPFQKDQYYTNQKE-DVLKFIRPYIFDQPHNGHANIIHLFDIIKDP 145 Query: 414 --DRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDN 471 V EYV+ + + + FY E+ L + S GI++RD+K N Sbjct: 146 ISKTPALVFEYVDN---VDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHN 202 Query: 472 VMLDS-EGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEII-AYQPYGKSVDWWAFGV 529 VM+D +++ D+G+ E + + + PE++ Y+ Y S+D W+FG Sbjct: 203 VMIDHKNKKLRLIDWGLA-EFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGT 261 Query: 530 LLYEMLAGQAP-FEGEDEDELFQSI-------------MEHNVAYPKSM----------- 564 +L M+ + P F G + I +++ + P+ Sbjct: 262 MLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPW 321 Query: 565 -------------SKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYI 603 + E + + L+ +RL ++ H +F I Sbjct: 322 HRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTA-----KEAMGHPWFAPI 368 >4M69-B nrPDB Length = 283 Score = 149 bits (377), Expect = 3e-36, Method: Composition-based stats. Identities = 44/247 (17%), Positives = 84/247 (34%), Gaps = 14/247 (5%) Query: 354 GKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMV-EKRVLALPGKPPFLTQLHSCFQ- 411 + E + +K+ V T E + + P L C Sbjct: 23 STIYRGEYHRS--PVTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICIDQ 80 Query: 412 --TMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKL 469 VMEY G L + + A GL+ L ++R++ Sbjct: 81 TVKPPEFSIVMEYCELGTLRELLDREKDLTMSVRSLLVLRAARGLYRLHHSETLHRNISS 140 Query: 470 DNVMLDSEGHIKIADFGMCKENIWDGVTTKT----FCGTPDYIAPEIIA--YQPYGKSVD 523 + ++ +K+A F + K T K+ + Y++PE + + Y + Sbjct: 141 SSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDIKAE 200 Query: 524 WWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYP--KSMSKEAVAICKGLMTKHPG 581 ++FG++L+E+ G+ PFEG D ++ + + E P + + I P Sbjct: 201 IYSFGIVLWEIATGKIPFEGCDSKKIRELVAEDKKQEPVGQDCPELLREIINECRAHEPS 260 Query: 582 KRLGCGP 588 +R Sbjct: 261 QRPSVDG 267 >4BTF-A nrPDB Length = 469 Score = 149 bits (377), Expect = 3e-36, Method: Composition-based stats. Identities = 44/247 (17%), Positives = 84/247 (34%), Gaps = 14/247 (5%) Query: 354 GKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMV-EKRVLALPGKPPFLTQLHSCFQ- 411 + E + +K+ V T E + + P L C Sbjct: 209 STIYRGEYHRS--PVTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICIDQ 266 Query: 412 --TMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKL 469 VMEY G L + + A GL+ L ++R++ Sbjct: 267 TVKPPEFSIVMEYCELGTLRELLDREKDLTMSVRSLLVLRAARGLYRLHHSETLHRNISS 326 Query: 470 DNVMLDSEGHIKIADFGMCKENIWDGVTTKT----FCGTPDYIAPEIIA--YQPYGKSVD 523 + ++ +K+A F + K T K+ + Y++PE + + Y + Sbjct: 327 SSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDIKAE 386 Query: 524 WWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYP--KSMSKEAVAICKGLMTKHPG 581 ++FG++L+E+ G+ PFEG D ++ + + E P + + I P Sbjct: 387 IYSFGIVLWEIATGKIPFEGCDSKKIRELVAEDKKQEPVGQDCPELLREIINECRAHEPS 446 Query: 582 KRLGCGP 588 +R Sbjct: 447 QRPSVDG 453 >2WTK-B nrPDB Length = 373 Score = 149 bits (376), Expect = 4e-36, Method: Composition-based stats. Identities = 58/384 (15%), Positives = 121/384 (31%), Gaps = 84/384 (21%) Query: 342 FNFLMVLGKGSFG---KVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 398 + L V+GKG F V L+ K T E V+ + + ++ V E V L Sbjct: 11 YELLTVIGKG-FEDLMTVNLARYKPTGEYVTVRRINLEAC-SNEMVTFLQGELHVSKLFN 68 Query: 399 KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQV--GRFKEPHAVFYAAEIAIGLFF 456 P + + F + L+ V ++ G I E + + L + Sbjct: 69 -HPNIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALDY 127 Query: 457 LQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDG---------VTTKTFCGTPDY 507 + G ++R +K ++++ +G + ++ G+ K + Sbjct: 128 IHHMGYVHRSVKASHILISVDGKVYLS--GLRSNLSMISHGQRQRVVHDFPKYSVKVLPW 185 Query: 508 IAPEIIAY--QPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNV------- 558 ++PE++ Q Y D ++ G+ E+ G PF+ ++ + V Sbjct: 186 LSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPCLLDTS 245 Query: 559 ---------------------------------------AYPKSMSKEAVAICKGLMTKH 579 Y ++ S + + ++ Sbjct: 246 TIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTFSPHFHHFVEQCLQRN 305 Query: 580 PGKRLGCGPEGERDIKEHAFFRYIDWEKLER-KEIQPPYKPKARDKRDTSNFDKEFTRQP 638 P R + H+FF+ I E E+ P P +NF+ ++ Sbjct: 306 PDARPSAST-----LLNHSFFKQIKRRASEALPELLRPVTP-------ITNFEGSQSQDH 353 Query: 639 VELTPTDKLFIMNLDQNEFAGFSY 662 + + NL++ E + + Sbjct: 354 SGIF----GLVTNLEELEVDDWEF 373 >5E8V-A nrPDB Length = 316 Score = 148 bits (374), Expect = 7e-36, Method: Composition-based stats. Identities = 54/318 (16%), Positives = 105/318 (33%), Gaps = 60/318 (18%) Query: 332 GNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTD----ELYAVKILKKDVVIQDDDVECT 387 G+ +L ++GKG F +V ++ K E AVKI + + Sbjct: 1 GHMHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDI 60 Query: 388 MVEKRVLALPGKPPFLTQLHSCFQTMDRL----YFVMEYVNGGDLMYHIQQVGRFKEPHA 443 + K + Q + + L + + + G+L ++ + Sbjct: 61 FSDIN-----LKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRH-VISWEDL 114 Query: 444 VFYAAEIAIGLFFLQS---------KGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIW- 493 + +A G+ L S I++RDLK N+++ ++ + DFG+ Sbjct: 115 RKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPT 174 Query: 494 ---DGVTTKTFCGTPDYIAPEII-------AYQPYGKSVDWWAFGVLLYEMLAG------ 537 D + GT Y+APE++ + + K D ++ ++L+EM + Sbjct: 175 LSVDDLANSGQVGTARYMAPEVLASAMNLENVESF-KQTDVYSMALVLWEMTSRCNAVGE 233 Query: 538 ----QAPF-----EGEDEDELFQSIM--EHNVAYPKSMSKE-----AVAICKGLMTKHPG 581 + PF E + +++ P P Sbjct: 234 VKDYEPPFGSKVREHPCVASMADNVLADAGRPEIPSFWLNHQGIQMVCETLTECWDHDPE 293 Query: 582 KRLG--CGPEGERDIKEH 597 RL C E ++ EH Sbjct: 294 ARLTAQCVAERFSEL-EH 310 >4LDC-A nrPDB Length = 149 Score = 147 bits (372), Expect = 1e-35, Method: Composition-based stats. Identities = 50/129 (38%), Positives = 71/129 (55%), Gaps = 4/129 (3%) Query: 157 ERRGRIYIQAHIDREV--LIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKT 214 E RGRI I + L+V + +L MD NG SDPYVK L PD +SK KT Sbjct: 2 EERGRILISLKYSSQKQGLLVGIVRCAHLAAMDANGYSDPYVKTYLKPDVDKKSKHKTAV 61 Query: 215 IKCSLNPEWNETFRFQLKESD-KDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKAGVDG 273 K +LNPE+NE F +++K D + L V +WD+D+ NDF+G + GI+ + + Sbjct: 62 KKKTLNPEFNEEFCYEIKHGDLAKKTLEVTVWDYDIGKSNDFIGGVVLGINA-KGERLKH 120 Query: 274 WFKLLSQEE 282 WF L ++ Sbjct: 121 WFDCLKNKD 129 >1RH8-A nrPDB Length = 142 Score = 146 bits (368), Expect = 4e-35, Method: Composition-based stats. Identities = 49/135 (36%), Positives = 73/135 (54%), Gaps = 12/135 (8%) Query: 160 GRIYIQAHIDREVLIVVVRDAKNLVPMDPNGLSDPYVKLKLIP---------DPKSESKQ 210 G I +Q + D LI+ + A+NLVP D NG SDP+VK+ L+P + +E K+ Sbjct: 7 GEIQLQINYDLGNLIIHILQARNLVPRDNNGYSDPFVKVYLLPGRGQVMVVQNASAEYKR 66 Query: 211 KTKTIKCSLNPEWNETFRFQLK--ESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQK 268 +TK ++ SLNPEWN+T ++ E + L V +WD+D S NDF+G + +S Sbjct: 67 RTKYVQKSLNPEWNQTVIYKSISMEQLMKKTLEVTVWDYDRFSSNDFLGEVLIDLSSTSH 126 Query: 269 -AGVDGWFKLLSQEE 282 W+ L Q E Sbjct: 127 LDNTPRWYPLKEQTE 141 >2KI6-A nrPDB Length = 128 Score = 145 bits (365), Expect = 7e-35, Method: Composition-based stats. Identities = 41/130 (31%), Positives = 69/130 (53%), Gaps = 6/130 (4%) Query: 157 ERRGRIYIQAHID--REVLIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKT 214 E+ G++ D L+V + A L +D G SDPYVK+ L+PD K K +TK Sbjct: 1 EKLGKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLLPDKKK--KFETKV 58 Query: 215 IKCSLNPEWNETFRFQLKESDK-DRRLSVEIWDWDLTSRNDFMGSLSFGISELQKAGV-D 272 + +LNP +NE F F++ S+ + L + ++D+D S++D +G ++ + V + Sbjct: 59 HRKTLNPVFNEQFTFKVPYSELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNTVDFGHVTE 118 Query: 273 GWFKLLSQEE 282 W L S E+ Sbjct: 119 EWRDLQSAEK 128 >3SOC-A nrPDB Length = 322 Score = 144 bits (364), Expect = 1e-34, Method: Composition-based stats. Identities = 66/295 (22%), Positives = 98/295 (33%), Gaps = 52/295 (17%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 L V +G FG V ++ +E AVKI IQD E L K Sbjct: 26 LQLLEVKARGRFGCVWKAQLL--NEYVAVKIF----PIQDKQSWQNEYEVYSLPGM-KHE 78 Query: 402 FLTQLHSCFQTMD----RLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFL 457 + Q + L+ + + G L + + A +A GL +L Sbjct: 79 NILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFL-KANVVSWNELCHIAETMARGLAYL 137 Query: 458 QS----------KGIIYRDLKLDNVMLDSEGHIKIADFGMC--KENIWDGVTTKTFCGTP 505 I +RD+K NV+L + IADFG+ E T GT Sbjct: 138 HEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTR 197 Query: 506 DYIAPEIIAY-----QPYGKSVDWWAFGVLLYEMLAGQA-----------PFE----GED 545 Y+APE++ + +D +A G++L+E+ + PFE Sbjct: 198 RYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHP 257 Query: 546 EDELFQSIMEHNVAYP---KSMSKEA-----VAICKGLMTKHPGKRLGCGPEGER 592 E Q ++ H P K A + RL G GER Sbjct: 258 SLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGER 312 >4F9B-A nrPDB Length = 361 Score = 144 bits (364), Expect = 1e-34, Method: Composition-based stats. Identities = 61/310 (19%), Positives = 106/310 (34%), Gaps = 69/310 (22%) Query: 342 FNFLMVLGKGSFGKVMLSERK---GTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 398 F +G+G+F V L+ + G +E A+K L E + L + G Sbjct: 23 FKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIR-----IAAELQCLTVAG 77 Query: 399 KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQ 458 + + CF+ D + M Y+ + + Y + L + Sbjct: 78 GQDNVMGVKYCFRKNDHVVIAMPYLEHESFLDILNS---LSFQEVREYMLNLFKALKRIH 134 Query: 459 SKGIIYRDLKLDNVMLDSEGHIK---IADFGMCKENIWDGVTTKTFC------------- 502 GI++RD+K N + + +K + DFG+ + + F Sbjct: 135 QFGIVHRDVKPSNFLYNR--RLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNK 192 Query: 503 ---------------GTPDYIAPEIIAYQP-YGKSVDWWAFGVLLYEMLAGQAPFEGEDE 546 GTP + APE++ P ++D W+ GV+ +L+G+ PF + Sbjct: 193 CSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASD 252 Query: 547 D----ELFQSIMEHNVAYPKS--------MSKE--AVAICKGLMTKHPGKRL----GCGP 588 D +I + SKE A + K +RL P Sbjct: 253 DLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLC------ERLRGMDSSTP 306 Query: 589 EGERDIKEHA 598 + DI+ HA Sbjct: 307 KLTSDIQGHA 316 >5LOB-A nrPDB Length = 162 Score = 144 bits (363), Expect = 1e-34, Method: Composition-based stats. Identities = 47/131 (35%), Positives = 75/131 (57%), Gaps = 4/131 (3%) Query: 157 ERRGRIYIQAHIDREV--LIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKT 214 E RG+I + + LIV + +L MD NG SDP+VKL L PD ++K KT+ Sbjct: 21 EERGKILVSLMYSTQQGGLIVGIIRCVHLAAMDANGYSDPFVKLWLKPDMGKKAKHKTQI 80 Query: 215 IKCSLNPEWNETFRFQLKESDKDRR-LSVEIWDWDLTSRNDFMGSLSFGISELQKAGVDG 273 K +LNPE+NE F + +K SD ++ L + +WD+D+ ND++G GIS + + Sbjct: 81 KKKTLNPEFNEEFFYDIKHSDLAKKSLDISVWDYDIGKSNDYIGGCQLGISA-KGERLKH 139 Query: 274 WFKLLSQEEGE 284 W++ L ++ + Sbjct: 140 WYECLKNKDKK 150 >2CM5-A nrPDB Length = 166 Score = 143 bits (362), Expect = 2e-34, Method: Composition-based stats. Identities = 47/131 (35%), Positives = 75/131 (57%), Gaps = 4/131 (3%) Query: 157 ERRGRIYIQAHIDREV--LIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKT 214 E RG+I + + LIV + +L MD NG SDP+VKL L PD ++K KT+ Sbjct: 21 EERGKILVSLMYSTQQGGLIVGIIRCVHLAAMDANGYSDPFVKLWLKPDMGKKAKHKTQI 80 Query: 215 IKCSLNPEWNETFRFQLKESDKDRR-LSVEIWDWDLTSRNDFMGSLSFGISELQKAGVDG 273 K +LNPE+NE F + +K SD ++ L + +WD+D+ ND++G GIS + + Sbjct: 81 KKKTLNPEFNEEFFYDIKHSDLAKKSLDISVWDYDIGKSNDYIGGCQLGISA-KGERLKH 139 Query: 274 WFKLLSQEEGE 284 W++ L ++ + Sbjct: 140 WYECLKNKDKK 150 >3F01-A nrPDB Length = 143 Score = 143 bits (361), Expect = 2e-34, Method: Composition-based stats. Identities = 40/131 (30%), Positives = 67/131 (51%), Gaps = 6/131 (4%) Query: 154 DHTERRGRIYIQAHID--REVLIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQK 211 E+ G++ D L+V + A L +D G SDPYVK+ L+PD K K + Sbjct: 15 SMVEKLGKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLLPDKKK--KFE 72 Query: 212 TKTIKCSLNPEWNETFRFQLKESDK-DRRLSVEIWDWDLTSRNDFMGSLSFGISELQKAG 270 TK + +LNP +NE F F++ S+ + L + ++D+D S++D +G ++ + Sbjct: 73 TKVHRKTLNPVFNEQFTFKVPYSELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNTVDFGH 132 Query: 271 V-DGWFKLLSQ 280 V + W L S Sbjct: 133 VTEEWRDLQSA 143 >1RSY-A nrPDB Length = 152 Score = 143 bits (360), Expect = 3e-34, Method: Composition-based stats. Identities = 40/127 (31%), Positives = 66/127 (51%), Gaps = 6/127 (4%) Query: 159 RGRIYIQAHID--REVLIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIK 216 G++ D L+V + A L +D G SDPYVK+ L+PD K K +TK + Sbjct: 28 LGKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLLPDKKK--KFETKVHR 85 Query: 217 CSLNPEWNETFRFQLKESDKD-RRLSVEIWDWDLTSRNDFMGSLSFGISELQKAGV-DGW 274 +LNP +NE F F++ S+ + L + ++D+D S++D +G ++ + V + W Sbjct: 86 KTLNPVFNEQFTFKVPYSELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNTVDFGHVTEEW 145 Query: 275 FKLLSQE 281 L S E Sbjct: 146 RDLQSAE 152 >3RPB-A nrPDB Length = 140 Score = 141 bits (355), Expect = 1e-33, Method: Composition-based stats. Identities = 46/129 (35%), Positives = 74/129 (57%), Gaps = 4/129 (3%) Query: 159 RGRIYIQAHIDREV--LIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIK 216 RG+I + + LIV + +L MD NG SDP+VKL L PD ++K KT+ K Sbjct: 1 RGKILVSLMYSTQQGGLIVGIIRCVHLAAMDANGYSDPFVKLWLKPDMGKKAKHKTQIKK 60 Query: 217 CSLNPEWNETFRFQLKESDKDRR-LSVEIWDWDLTSRNDFMGSLSFGISELQKAGVDGWF 275 +LNPE+NE F + +K SD ++ L + +WD+D+ ND++G GIS + + W+ Sbjct: 61 KTLNPEFNEEFFYDIKHSDLAKKSLDISVWDYDIGKSNDYIGGCQLGISA-KGERLKHWY 119 Query: 276 KLLSQEEGE 284 + L ++ + Sbjct: 120 ECLKNKDKK 128 >6ANK-A nrPDB Length = 289 Score = 140 bits (352), Expect = 2e-33, Method: Composition-based stats. Identities = 45/131 (34%), Positives = 69/131 (52%), Gaps = 6/131 (4%) Query: 153 TDHTERRGRIYIQ--AHIDREVLIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQ 210 E GRI + L V V A+ L D +G SDP+VK+ L+PD K K Sbjct: 16 MGRLENLGRIQFSVGYNFQESTLTVKVMKAQELPAKDFSGTSDPFVKIYLLPDKKH--KL 73 Query: 211 KTKTIKCSLNPEWNETFRFQLKESDK--DRRLSVEIWDWDLTSRNDFMGSLSFGISELQK 268 +TK + +LNP WNETF F+ +K R L +++ D+D SRND +G +S ++++ Sbjct: 74 ETKVKRKNLNPHWNETFLFEGFPYEKVVQRILYLQVLDYDRFSRNDPIGEVSIPLNKVDL 133 Query: 269 AGVDGWFKLLS 279 + ++K L Sbjct: 134 TQMQTFWKDLK 144 Score = 114 bits (286), Expect = 1e-25, Method: Composition-based stats. Identities = 40/128 (31%), Positives = 63/128 (49%), Gaps = 4/128 (3%) Query: 159 RGRIYIQAHI--DREVLIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIK 216 RG + + +IV + A+NL MD G SDPYVK+ L+ K K+KT T K Sbjct: 153 RGELLLSLCYNPSANSIIVNIIKARNLKAMDIGGTSDPYVKVWLMYKDKRVEKKKTVTKK 212 Query: 217 CSLNPEWNETFRFQLK-ESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKAGVDGWF 275 +LNP +NE+F F + E ++ + + + D D SRND +G + V W Sbjct: 213 RNLNPIFNESFAFDIPTEKLRETTIIITVMDKDKLSRNDVIGKIYLSWKS-GPGEVKHWK 271 Query: 276 KLLSQEEG 283 ++++ Sbjct: 272 DMIARPRQ 279 >5H4Y-A nrPDB Length = 150 Score = 140 bits (352), Expect = 2e-33, Method: Composition-based stats. Identities = 39/131 (29%), Positives = 65/131 (49%), Gaps = 6/131 (4%) Query: 158 RRGRIYIQAHID--REVLIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTI 215 G++ D L+V + A L +D G SDPYV++ L+PD + + +TK Sbjct: 16 ELGQLQYSLDYDFQSGQLLVGILQAMGLAALDLGGSSDPYVRVYLLPDKRR--RYETKVH 73 Query: 216 KCSLNPEWNETFRFQLKE-SDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKA-GVDG 273 + +LNP + ETF F++ R L + ++D+D SRND +G + +S + V Sbjct: 74 RQTLNPHFGETFAFKVPYVELGGRVLVMAVYDFDRFSRNDAIGEVRVPMSSVDLGRPVQA 133 Query: 274 WFKLLSQEEGE 284 W +L + E Sbjct: 134 WRELQAAPREE 144 >5X18-A nrPDB Length = 295 Score = 140 bits (352), Expect = 2e-33, Method: Composition-based stats. Identities = 49/251 (19%), Positives = 88/251 (35%), Gaps = 28/251 (11%) Query: 341 DFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKP 400 + +G+GSFG + A+K + + E + + Sbjct: 8 HYKIGKKIGEGSFGVLFEGTNMINGVPVAIKF-----EPRKTEAPQLRDEYKTYKILNGT 62 Query: 401 PFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR-FKEPHAVFYAAEIAIGLFFLQS 459 P + + Q V++ + G L GR F V A ++ + L + Sbjct: 63 PNIPYAYYFGQEGLHNILVIDLL-GPSLEDLFDWCGRKFSVKTVVQVAVQMITLIEDLHA 121 Query: 460 KGIIYRDLKLDNVMLDSEGH-----IKIADFGMCKENIWDGVT-------TKTFCGTPDY 507 +IYRD+K DN ++ G I + DFGM K+ K+ GT Y Sbjct: 122 HDLIYRDIKPDNFLIGRPGQPDANNIHLIDFGMAKQYRDPKTKQHIPYREKKSLSGTARY 181 Query: 508 IAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEG---EDEDELFQSIMEHNVAYPKSM 564 ++ + + D A G + + L G P++G + + ++ I E Sbjct: 182 MSINTHLGREQSRRDDMEALGHVFFYFLRGHLPWQGLKAPNNKQKYEKIGEKKR------ 235 Query: 565 SKEAVAICKGL 575 S + +GL Sbjct: 236 STNVYDLAQGL 246 >5M07-A nrPDB Length = 276 Score = 138 bits (349), Expect = 5e-33, Method: Composition-based stats. Identities = 53/268 (19%), Positives = 94/268 (35%), Gaps = 37/268 (13%) Query: 337 MKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLAL 396 + + + +LG + G+V L + G A+K+L + D+ E V A Sbjct: 27 VTFAGYTVVRMLGASAMGEVYLVQHPGFPGWQALKVLSPAMAADDEFRRRFQRETEVAAR 86 Query: 397 PGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR--FKEPHAVFYAAEIAIGL 454 P + ++H + +L+ M+YV+G D H+ + +A L Sbjct: 87 LF-HPHILEVHDRGEFDGQLWIAMDYVDGIDATQHMADRFPAVLPVGEVLAIVTAVAGAL 145 Query: 455 FFLQSKGIIYRDLKLDNVMLDS----EGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAP 510 + +G+++RD+ NV+L S + I +ADFG+ + P Y AP Sbjct: 146 DYAHQRGLLHRDVNPANVVLTSQSAGDQRILLADFGIASQ--------------PSYPAP 191 Query: 511 EIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVA 570 E+ A D +A + + AG P + P +S Sbjct: 192 ELSAGADVDGRADQYALALTAIHLFAGAPPVDRS----------HTGPLQPPKLSAFRPD 241 Query: 571 I------CKGLMTKHPGKRLGCGPEGER 592 + + P R G E Sbjct: 242 LARLDGVLSRALATAPADRFGSCREFAD 269 >2CHL-A nrPDB Length = 351 Score = 138 bits (349), Expect = 6e-33, Method: Composition-based stats. Identities = 53/237 (22%), Positives = 92/237 (38%), Gaps = 22/237 (9%) Query: 341 DFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKP 400 +F +G G+FG++ L + T+E A+K + +E R G Sbjct: 31 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIK-----LEPMKSRAPQLHLEYRFYKQLGSG 85 Query: 401 PFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR-FKEPHAVFYAAEIAIGLFFLQS 459 + Q++ V+E + G L R F + A ++ + ++ S Sbjct: 86 DGIPQVYYFGPCGKYNAMVLELL-GPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHS 144 Query: 460 KGIIYRDLKLDNVMLDSEGH-----IKIADFGMCKENIWDGVTT-------KTFCGTPDY 507 K +IYRD+K +N ++ G+ I I DF + KE I K+ GT Y Sbjct: 145 KNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARY 204 Query: 508 IAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEG---EDEDELFQSIMEHNVAYP 561 ++ + + D A G + L G P++G + E +Q I + A P Sbjct: 205 MSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATP 261 >6ANJ-A nrPDB Length = 148 Score = 138 bits (347), Expect = 9e-33, Method: Composition-based stats. Identities = 45/131 (34%), Positives = 69/131 (52%), Gaps = 6/131 (4%) Query: 153 TDHTERRGRIYIQ--AHIDREVLIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQ 210 E GRI + L V V A+ L D +G SDP+VK+ L+PD K K Sbjct: 16 MGRLENLGRIQFSVGYNFQESTLTVKVMKAQELPAKDFSGTSDPFVKIYLLPDKKH--KL 73 Query: 211 KTKTIKCSLNPEWNETFRFQLKESDK--DRRLSVEIWDWDLTSRNDFMGSLSFGISELQK 268 +TK + +LNP WNETF F+ +K R L +++ D+D SRND +G +S ++++ Sbjct: 74 ETKVKRKNLNPHWNETFLFEGFPYEKVVQRILYLQVLDYDRFSRNDPIGEVSIPLNKVDL 133 Query: 269 AGVDGWFKLLS 279 + ++K L Sbjct: 134 TQMQTFWKDLK 144 >2D8K-A nrPDB Length = 141 Score = 138 bits (347), Expect = 1e-32, Method: Composition-based stats. Identities = 44/127 (34%), Positives = 69/127 (54%), Gaps = 6/127 (4%) Query: 157 ERRGRIYIQ--AHIDREVLIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKT 214 E GRI + L V + A+ L D +G SDP+VK+ L+PD K K +TK Sbjct: 10 ENLGRIQFSVGYNFQESTLTVKIMKAQELPAKDFSGTSDPFVKIYLLPDKKH--KLETKV 67 Query: 215 IKCSLNPEWNETFRFQLKESDK--DRRLSVEIWDWDLTSRNDFMGSLSFGISELQKAGVD 272 + +LNP WNETF F+ +K R L +++ D+D SRND +G +S ++++ + Sbjct: 68 KRKNLNPHWNETFLFEGFPYEKVVQRILYLQVLDYDRFSRNDPIGEVSIPLNKVDLTQMQ 127 Query: 273 GWFKLLS 279 ++K L Sbjct: 128 TFWKDLK 134 >2C47-A nrPDB Length = 313 Score = 137 bits (346), Expect = 1e-32, Method: Composition-based stats. Identities = 56/254 (22%), Positives = 99/254 (38%), Gaps = 27/254 (10%) Query: 341 DFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKP 400 +F +G G+FG++ L + T+E A+K L+ K++ A G P Sbjct: 5 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIK-LEPIKSRAPQLHLEYRFYKQLSATEGVP 63 Query: 401 PFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR-FKEPHAVFYAAEIAIGLFFLQS 459 Q++ V+E + G L R F + A ++ + ++ + Sbjct: 64 ----QVYYFGPCGKYNAMVLELL-GPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYVHT 118 Query: 460 KGIIYRDLKLDNVMLDSEGH-----IKIADFGMCKENIWDGVTT-------KTFCGTPDY 507 K +IYRD+K +N ++ G I I DFG+ KE I K+ GT Y Sbjct: 119 KSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARY 178 Query: 508 IAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEG---EDEDELFQSIMEHNVAYP--- 561 ++ + + D A G + L G P++G + E +Q I + A P Sbjct: 179 MSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEV 238 Query: 562 --KSMSKEAVAICK 573 ++ +E + Sbjct: 239 LCENFPEEMATYLR 252 >2QLU-A nrPDB Length = 314 Score = 137 bits (345), Expect = 2e-32, Method: Composition-based stats. Identities = 57/292 (19%), Positives = 100/292 (34%), Gaps = 55/292 (18%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG-KP 400 L + +G FG V ++ AVKI D + E+ + + PG K Sbjct: 17 LQLLEIKARGRFGCVWKAQLMND--FVAVKIFPL------QDKQSWQSEREIFSTPGMKH 68 Query: 401 PFLTQLHSCFQTMD----RLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFF 456 L Q + + L+ + + + G L ++ + A ++ GL + Sbjct: 69 ENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYL-KGNIITWNELCHVAETMSRGLSY 127 Query: 457 LQS-----------KGIIYRDLKLDNVMLDSEGHIKIADFGMCK--ENIWDGVTTKTFCG 503 L I +RD K NV+L S+ +ADFG+ E T G Sbjct: 128 LHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVG 187 Query: 504 TPDYIAPEIIAY-----QPYGKSVDWWAFGVLLYEMLAGQ-----------APFEGE--- 544 T Y+APE++ + +D +A G++L+E+++ PFE E Sbjct: 188 TRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQ 247 Query: 545 --DEDELFQSI--MEHNVAYPKSM--SKEAVAI---CKGLMTKHPGKRLGCG 587 +EL + + + + + RL G Sbjct: 248 HPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAG 299 >2CMW-A nrPDB Length = 310 Score = 136 bits (343), Expect = 3e-32, Method: Composition-based stats. Identities = 56/262 (21%), Positives = 102/262 (38%), Gaps = 46/262 (17%) Query: 343 NFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPF 402 +G G+FG++ L + T+E A+K+ ++ R L + F Sbjct: 3 RVGKKIGCGNFGELRLGKNLYTNEYVAIKL--------------EPIKSRAPQLHLEYRF 48 Query: 403 LTQLHSCFQTMDRLY----------FVMEYVNGGDLMYHIQQVGR-FKEPHAVFYAAEIA 451 QL S + + ++Y V+E + G L R F + A ++ Sbjct: 49 YKQLGSAGEGLPQVYYFGPCGKYNAMVLELL-GPSLEDLFDLCDRTFTLKTVLMIAIQLL 107 Query: 452 IGLFFLQSKGIIYRDLKLDNVMLDSEGH-----IKIADFGMCKENIWDGVTT-------K 499 + ++ SK +IYRD+K +N ++ +G+ I I DFG+ KE I K Sbjct: 108 SRMEYVHSKNLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHK 167 Query: 500 TFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEG---EDEDELFQSIMEH 556 + GT Y++ + + D A G + L G P++G + E +Q I + Sbjct: 168 SLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDT 227 Query: 557 NVAYP-----KSMSKEAVAICK 573 P ++ +E + Sbjct: 228 KRNTPIEALCENFPEEMATYLR 249 >2CHD-A nrPDB Length = 142 Score = 135 bits (341), Expect = 4e-32, Method: Composition-based stats. Identities = 43/132 (32%), Positives = 68/132 (51%), Gaps = 4/132 (3%) Query: 153 TDHTERRGRIYIQAHIDREV--LIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQ 210 +D G + D++ L + AK L PMD NGL+DPYVKL L+P +K Sbjct: 9 SDQATTLGALEFSLLYDQDNSNLQCTIIRAKGLKPMDSNGLADPYVKLHLLPGASKSNKL 68 Query: 211 KTKTIKCSLNPEWNETFRFQ-LKESDKDRR-LSVEIWDWDLTSRNDFMGSLSFGISELQK 268 +TKT++ + NP WNET ++ + E D R+ L + + D D N+F+G F + +L+ Sbjct: 69 RTKTLRNTRNPVWNETLQYHGITEEDMQRKTLRISVCDEDKFGHNEFIGETRFSLKKLKA 128 Query: 269 AGVDGWFKLLSQ 280 + L + Sbjct: 129 NQRKNFNICLER 140 >4LCV-A nrPDB Length = 138 Score = 135 bits (341), Expect = 5e-32, Method: Composition-based stats. Identities = 42/132 (31%), Positives = 67/132 (50%), Gaps = 4/132 (3%) Query: 154 DHTERRGRIYIQAHIDREV--LIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQK 211 + G + D+E L + AK L PMD NGL+DPYVKL L+P +K + Sbjct: 5 SGSTALGTLDFSLLYDQENNALHCTISKAKGLKPMDHNGLADPYVKLHLLPGASKANKLR 64 Query: 212 TKTIKCSLNPEWNETFRFQ-LKESDKDRR-LSVEIWDWDLTSRNDFMGSLSFGISELQKA 269 TKT++ +LNP WNET + + + D R+ L + + D D N+F+G + +L+ Sbjct: 65 TKTLRNTLNPSWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETRVPLKKLKPN 124 Query: 270 GVDGWFKLLSQE 281 + L ++ Sbjct: 125 HTKTFSICLEKQ 136 >4MJJ-A nrPDB Length = 138 Score = 135 bits (341), Expect = 5e-32, Method: Composition-based stats. Identities = 43/133 (32%), Positives = 64/133 (48%), Gaps = 4/133 (3%) Query: 153 TDHTERRGRIYIQAHIDRE--VLIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQ 210 +D G + DR L + AK L PMD NGL+DPYVKL L+P +K Sbjct: 5 SDDATALGTLEFDLLYDRASCTLHCSILRAKGLKPMDFNGLADPYVKLHLLPGACKANKL 64 Query: 211 KTKTIKCSLNPEWNETFRFQLKESDK--DRRLSVEIWDWDLTSRNDFMGSLSFGISELQK 268 KTKT + +LNP WNE + D + L + + D D S N+F+G + + L+ Sbjct: 65 KTKTQRNTLNPVWNEDLTYSGITDDDITHKVLRIAVCDEDKLSHNEFIGEIRVPLRRLKP 124 Query: 269 AGVDGWFKLLSQE 281 + + L ++ Sbjct: 125 SQKKHFNICLERQ 137 >4NT4-A nrPDB Length = 312 Score = 135 bits (340), Expect = 6e-32, Method: Composition-based stats. Identities = 68/315 (21%), Positives = 116/315 (36%), Gaps = 49/315 (15%) Query: 341 DFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKP 400 +F +G G+FG++ L + +E A+K+ +E R L G Sbjct: 13 NFRVGKKIGCGNFGELRLGKNLYNNEHVAIKM-----EPMKSKAPQLHLEYRFYKLLGSH 67 Query: 401 --------PFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR-FKEPHAVFYAAEIA 451 P + L +C + V+E + G L R F + A ++ Sbjct: 68 ADNAPDGIPRIYHLGTCGGRYNA--MVLELL-GLSLEDLFNICARKFSLKTVLMIAKQLL 124 Query: 452 IGLFFLQSKGIIYRDLKLDNVMLD-----SEGHIKIADFGMCKENIW-------DGVTTK 499 + ++ S+ +IYRD+K +N ++ E I I DFG+ KE I K Sbjct: 125 HRIEYVHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRHIPYREHK 184 Query: 500 TFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEG---EDEDELFQSIMEH 556 + GT Y++ + + D A G + L G P++G + E +Q I + Sbjct: 185 SLTGTARYMSINTHMGREQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDT 244 Query: 557 NVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPP 616 A P + L HP + R ++ FF D++ L R+ Q Sbjct: 245 KRATP----------IEVLCDGHPEE----FATYLRYVRRLDFFETPDYDFL-RRLFQDL 289 Query: 617 YKPKARDKRDTSNFD 631 + + D FD Sbjct: 290 F--DRKGYTDEGEFD 302 >4MWI-A nrPDB Length = 294 Score = 135 bits (339), Expect = 8e-32, Method: Composition-based stats. Identities = 45/234 (19%), Positives = 82/234 (35%), Gaps = 16/234 (6%) Query: 368 YAVKILKKDVVIQDDDVECTMV-EKRVLALPGKPPFLTQLHSCFQ---TMDRLYFVMEYV 423 A+K+ KK V T E + + P L C T + VMEY Sbjct: 50 VAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYC 109 Query: 424 NGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQ--SKGIIYRDLKLDNVMLDSEGHIK 481 G L + + + A GL+ L ++ ++ N ++ +K Sbjct: 110 ELGTLRELLDREKDLTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQVK 169 Query: 482 IADFGMCKENIW----DGVTTKTFCGTPDYIAP---EIIAYQPYGKSVDWWAFGVLLYEM 534 +A F + K + Y++P E + YQ Y + ++FG++L+E+ Sbjct: 170 LAGFELRKTQTSMSLGTTREKTDRVKSTAYLSPQELEDVFYQ-YDVKSEIYSFGIVLWEI 228 Query: 535 LAGQAPFEGEDEDELFQSIMEHNVAYP--KSMSKEAVAICKGLMTKHPGKRLGC 586 G PF+G + +++ + + P + E I P R Sbjct: 229 ATGDIPFQGCNSEKIRKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSV 282 >1DQV-A nrPDB Length = 296 Score = 133 bits (335), Expect = 2e-31, Method: Composition-based stats. Identities = 45/162 (27%), Positives = 73/162 (45%), Gaps = 9/162 (5%) Query: 152 GTDHTERRGRIYIQAHI--DREVLIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESK 209 G G + +L V + A NL MD G SDPYVK LI + + K Sbjct: 131 GGSEKADLGELNFSLCYLPTAGLLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKK 190 Query: 210 QKTKTIKCSLNPEWNETFRFQL-KESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQK 268 +KT K +LNP +NE F + ES ++ LS+ + D+D N+ +G G Sbjct: 191 RKTSIKKNTLNPTYNEALVFDVAPESVENVGLSIAVVDYDCIGHNEVIGVCRVGPEAADP 250 Query: 269 AGVDGWFKLLSQEEG--EYFNVPVPPEG----SEGNEELRQK 304 G + W ++L+ E+++ V + ++G + L +K Sbjct: 251 HGREHWAEMLANPRKPVEHWHQLVEEKTLSSFTKGGKGLSEK 292 Score = 125 bits (313), Expect = 8e-29, Method: Composition-based stats. Identities = 43/126 (34%), Positives = 66/126 (52%), Gaps = 8/126 (6%) Query: 160 GRIYIQAHI--DREVLIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKC 217 GRI + L+V + A +L D NG SDPYVK+ L+PD + K +TK + Sbjct: 7 GRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPD--RKKKFQTKVHRK 64 Query: 218 SLNPEWNETFRFQLK-ESDKDRRLSVEIWDWDLTSRNDFMGSLSFG-ISELQKAGVDG-- 273 +LNP +NETF+F + R+L ++D+D SR+D +G + + EL + D Sbjct: 65 TLNPIFNETFQFSVPLAELAQRKLHFSVYDFDRFSRHDLIGQVVLDNLLELAEQPPDRPL 124 Query: 274 WFKLLS 279 W +L Sbjct: 125 WRDILE 130 >4WUA-A nrPDB Length = 401 Score = 133 bits (334), Expect = 3e-31, Method: Composition-based stats. Identities = 51/294 (17%), Positives = 91/294 (30%), Gaps = 66/294 (22%) Query: 318 EEKTANTISKFDNNGNRDRMKLTD-----FNFLMVLGKGSFGKVMLSERKGTDELYAVKI 372 + G +K+ D ++ + LG G F V LS + A+K+ Sbjct: 14 SDDDEQEDPNDYCKGGYHLVKIGDLFNGRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKV 73 Query: 373 LKKDVVIQDDDVECTMVEKRVLALPGKPPF---LTQLHSCFQ----TMDRLYFVMEYVNG 425 +K + ++ + K V P + QL F+ + V E + Sbjct: 74 VKSAEHYTETALDEIRLLKSVRNSDPNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGH 133 Query: 426 GDLMYHIQQVGR-FKEPHAVFYAAEIAIGLFFLQSK-GIIYRDLKLDNVMLD-------- 475 L + I+ + P ++ GL +L +K II+ D+K +N++L Sbjct: 134 HLLKWIIKSNYQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRR 193 Query: 476 -----------------------------------------SEGHIKIADFGMCKENIWD 494 + +KIAD G W Sbjct: 194 LAAEATEWQRSGAPPPSGSAVSTAPATAGNFLVNPLEPKNAEKLKVKIADLGNA---CWV 250 Query: 495 GVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDE 548 T Y + E++ Y D W+ + +E+ G FE +E Sbjct: 251 HKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDYLFEPHSGEE 304 >5FQD-C nrPDB Length = 341 Score = 132 bits (333), Expect = 4e-31, Method: Composition-based stats. Identities = 47/250 (18%), Positives = 91/250 (36%), Gaps = 20/250 (8%) Query: 329 DNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTM 388 + + + + + +G GSFG + L+ E AVK+ + E + Sbjct: 8 SSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKL 67 Query: 389 VEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQV-GRFKEPHAVFYA 447 ++L P + Q D VM+ + G L RF + A Sbjct: 68 Y--KILQGGVGIPHIRWYG---QEKDYNVLVMDLL-GPSLEDLFNFCSRRFTMKTVLMLA 121 Query: 448 AEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHI-K--IADFGMCKENIWDGVTT------ 498 ++ + ++ +K I+RD+K DN ++ H K + DFG+ K+ + Sbjct: 122 DQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYRE 181 Query: 499 -KTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGE---DEDELFQSIM 554 K GT Y + + D + G +L P++G + + ++ I Sbjct: 182 DKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKIS 241 Query: 555 EHNVAYPKSM 564 E ++ P + Sbjct: 242 EKKMSTPVEV 251 >3SV0-A nrPDB Length = 483 Score = 132 bits (331), Expect = 7e-31, Method: Composition-based stats. Identities = 50/234 (21%), Positives = 86/234 (36%), Gaps = 20/234 (8%) Query: 340 TDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK 399 F +G GSFG++ L T+E A+K L+ + + + R+L Sbjct: 7 NKFRLGRKIGSGSFGEIYLGTNIQTNEEVAIK-LENVKTKHPQLLYESKIY-RILQGGTG 64 Query: 400 PPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR-FKEPHAVFYAAEIAIGLFFLQ 458 P + D VM+ + G L R + A ++ + F+ Sbjct: 65 IPNVRWFGV---EGDYNVLVMDLL-GPSLEDLFNFCSRKLSLKTVLMLADQMINRVEFVH 120 Query: 459 SKGIIYRDLKLDNVMLD---SEGHIKIADFGMCKENIWDGVT-------TKTFCGTPDYI 508 SK ++RD+K DN ++ + I DFG+ K+ K GT Y Sbjct: 121 SKSFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDTSTHQHIPYRENKNLTGTARYA 180 Query: 509 APEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGE---DEDELFQSIMEHNVA 559 + + D + G +L L G P++G + + ++ I E VA Sbjct: 181 SVNTHLGIEQSRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKYEKISEKKVA 234 >2X7G-A nrPDB Length = 389 Score = 131 bits (330), Expect = 8e-31, Method: Composition-based stats. Identities = 52/318 (16%), Positives = 96/318 (30%), Gaps = 78/318 (24%) Query: 318 EEKTANTISKFDNNGNRDRMKLTD-----FNFLMVLGKGSFGKVMLSERKGTDELYAVKI 372 + G +K+ D ++ + LG G F V L A+K+ Sbjct: 4 SDDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKV 63 Query: 373 LKKDVVIQDDDVECTMVEKRVLALPGKP----PF---LTQLHSCFQTMD----RLYFVME 421 +K E + E ++L + P + QL F+ + V E Sbjct: 64 VK----SAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFE 119 Query: 422 YVNGGDLMYHIQQVGR-FKEPHAVFYAAEIAIGLFFLQSK-GIIYRDLKLDNVML----- 474 + L + I+ + ++ GL +L SK II+ D+K +N+++ Sbjct: 120 VLGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDA 179 Query: 475 ------------------------------------------DSEGHIKIADFGMCKENI 492 + +KIAD G Sbjct: 180 YVRRMAAEATEWQKAGAPPPSGSAVSTAPAADLLVNPLDPRNADKIRVKIADLGNA---C 236 Query: 493 WDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGED------E 546 W T Y + E++ Y D W+ + +E+ G FE + Sbjct: 237 WVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLFEPHSGEDYSRD 296 Query: 547 DELFQSIMEHNVAYPKSM 564 ++ I+E + P+ Sbjct: 297 EDHIAHIIELLGSIPRHF 314 >4TN6-A nrPDB Length = 318 Score = 129 bits (325), Expect = 3e-30, Method: Composition-based stats. Identities = 48/236 (20%), Positives = 86/236 (36%), Gaps = 20/236 (8%) Query: 340 TDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK 399 + +G GSFG + L E A+K + +E ++ + Sbjct: 7 NRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIK-----LECVKTKHPQLHIESKIYKMMQG 61 Query: 400 PPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR-FKEPHAVFYAAEIAIGLFFLQ 458 + + C D VME + G L R F + A ++ + ++ Sbjct: 62 GVGIPTIRWCGAEGDYNVMVMELL-GPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIH 120 Query: 459 SKGIIYRDLKLDNVM--LDSEGHIK-IADFGMCKENIWDGVT-------TKTFCGTPDYI 508 SK I+RD+K DN + L +G++ I DFG+ K+ K GT Y Sbjct: 121 SKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYA 180 Query: 509 APEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGE---DEDELFQSIMEHNVAYP 561 + + D + G +L G P++G + + ++ I E ++ P Sbjct: 181 SINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTP 236 >5OAT-A nrPDB Length = 411 Score = 129 bits (324), Expect = 4e-30, Method: Composition-based stats. Identities = 64/320 (20%), Positives = 117/320 (36%), Gaps = 65/320 (20%) Query: 335 DRMKLTDFNFLMVLGKGSFGKVMLSERKGTDE-----LYAVKIL-KKDVVIQDDDVECTM 388 + + L D + + KG+ G V ++ K + +A+K++ D+ ++ M Sbjct: 6 NPITLNDLSLGKPIAKGTNGVVYSAKVKDDETDDNKYPFALKMMFNYDIQENSMEILKAM 65 Query: 389 V------------------EKRVLALPGK---PPFLTQLHSCFQTMDR------------ 415 E + P + + S F + Sbjct: 66 YRETVPARMYYSNHDLNNWEIELANRRKHLPPHPNIVAIFSVFTDLYPAALPPRLHPEGE 125 Query: 416 -----LYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLD 470 L+ +M+ + +L + ++ A++ G+ + + GI +RDLK D Sbjct: 126 GRNMSLFLLMKRYDC-NLQSFLSTAP--STRTSLLLLAQLLEGVAHMTAHGIAHRDLKSD 182 Query: 471 NVMLD----SEGHIKIADFGMCKENIWDGVTTK------TFCGTPDYIAPEIIAYQPYGK 520 N++LD + I+DFG C + +G++ G +APEII +P Sbjct: 183 NLLLDTSEPESPILVISDFGCCLADKTNGLSLPYTSYEMDKGGNTALMAPEIICQKPGTF 242 Query: 521 SV------DWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKG 574 SV D WA G + YE+ PF G + F P + A+ Sbjct: 243 SVLNYSKADLWAVGAIAYEIFNCHNPFYGPSRLKNFNYKEGDLPKLPDEVPTVIQALVAN 302 Query: 575 LMTKHPGKRLGCGPEGERDI 594 L+ ++P KRL PE ++ Sbjct: 303 LLKRNPNKRL--DPEVAANV 320 >5X1R-A nrPDB Length = 302 Score = 128 bits (322), Expect = 7e-30, Method: Composition-based stats. Identities = 51/294 (17%), Positives = 99/294 (33%), Gaps = 32/294 (10%) Query: 325 ISKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDD- 383 I+K ++N + +F +G+G FG V + + A+K + + +D Sbjct: 6 ITKPNSNSLPSGYRFNEFEIQEAIGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAKRNDD 65 Query: 384 -----------------VECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGG 426 + + E R+LA P L + ++ Y ++ +G Sbjct: 66 LSIGLRGERFGKTFQAGLNSFIQEARLLARFS-HPGLLHVLRFWEENGTAYMGTQFYSGT 124 Query: 427 DLMYH-IQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADF 485 L QQ + E + + + +G ++RD+ LDN+ + + DF Sbjct: 125 TLKNLQAQQPEKIDEAWIRRLLPPLFSAINTIHQEGYLHRDISLDNIQIQESQLPVLLDF 184 Query: 486 GMCKENIWDGVTTKTFCGTPDYIAPEII---AYQPYGKSVDWWAFGVLLYEMLAGQAPFE 542 G ++ I + P + E + G D +A G +L+ ++ G P Sbjct: 185 GSARKEIGNLSDETEIVLKPGFAPIEQYTENSDGEQGPWTDIYALGAVLHTLIVGSPP-- 242 Query: 543 GEDEDELFQSIMEH----NVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGER 592 + +SI + P S E + + P R E Sbjct: 243 ---PVSVVRSIEDSYQPLTERRPAGYSPELLRTVDRALALKPEDRPQTIDEMAE 293 >4BTK-A nrPDB Length = 337 Score = 128 bits (321), Expect = 9e-30, Method: Composition-based stats. Identities = 45/225 (20%), Positives = 80/225 (35%), Gaps = 18/225 (8%) Query: 343 NFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPF 402 L +G G FG++ + T E A+K+ + +E VL Sbjct: 59 KVLKKIGGGGFGEIYEAMDLLTRENVALKV-----ESAQQPKQVLKMEVAVLKKLQGKDH 113 Query: 403 LTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQ--VGRFKEPHAVFYAAEIAIGLFFLQSK 460 + + C + Y VM+ G +L + G F + +I + + S Sbjct: 114 VCRFIGCGRNEKFNYVVMQL-QGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHSV 172 Query: 461 GIIYRDLKLDNV----MLDSEGHIKIADFGMCKENIWDGVTTK------TFCGTPDYIAP 510 G ++RD+K N + + + DFG+ ++ + F GT Y + Sbjct: 173 GFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRYASV 232 Query: 511 EIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIME 555 + G+ D W+ +L E GQ P+ + E I E Sbjct: 233 NAHKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKE 277 >4NFN-A nrPDB Length = 309 Score = 127 bits (320), Expect = 1e-29, Method: Composition-based stats. Identities = 45/225 (20%), Positives = 80/225 (35%), Gaps = 18/225 (8%) Query: 343 NFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPF 402 L +G G FG++ + T E A+K+ + +E VL Sbjct: 24 KVLKKIGGGGFGEIYEAMDLLTRENVALKV-----ESAQQPKQVLKMEVAVLKKLQGKDH 78 Query: 403 LTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQ--VGRFKEPHAVFYAAEIAIGLFFLQSK 460 + + C + Y VM+ G +L + G F + +I + + S Sbjct: 79 VCRFIGCGRNEKFNYVVMQL-QGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHSV 137 Query: 461 GIIYRDLKLDNV----MLDSEGHIKIADFGMCKENIWDGVTTK------TFCGTPDYIAP 510 G ++RD+K N + + + DFG+ ++ + F GT Y + Sbjct: 138 GFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRYASV 197 Query: 511 EIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIME 555 + G+ D W+ +L E GQ P+ + E I E Sbjct: 198 NAHKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKE 242 >2E73-A nrPDB Length = 77 Score = 127 bits (319), Expect = 2e-29, Method: Composition-based stats. Identities = 59/71 (83%), Positives = 64/71 (90%) Query: 36 NHKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPAS 95 HKFTARFFKQPTFCSHCTDFIWG GKQG QCQVC FVVH+RCHEFVTF CPGA KGP + Sbjct: 7 GHKFTARFFKQPTFCSHCTDFIWGIGKQGLQCQVCSFVVHRRCHEFVTFECPGAGKGPQT 66 Query: 96 DDPRSKHKFKI 106 DDPR+KHKF++ Sbjct: 67 DDPRNKHKFRL 77 Score = 71.9 bits (175), Expect = 8e-13, Method: Composition-based stats. Identities = 20/50 (40%), Positives = 27/50 (54%) Query: 102 HKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLC 151 HKF + PTFC HC ++G+ QG++C C VH+RC V C Sbjct: 8 HKFTARFFKQPTFCSHCTDFIWGIGKQGLQCQVCSFVVHRRCHEFVTFEC 57 >4L00-A nrPDB Length = 304 Score = 127 bits (319), Expect = 2e-29, Method: Composition-based stats. Identities = 63/301 (20%), Positives = 111/301 (36%), Gaps = 47/301 (15%) Query: 335 DRMKLTDFNFLMVLGKGS-----FGKVM-LSERKGTDELYAVKILKKDVVIQDDDVECTM 388 DR+ D LG+G+ G +M + +GT E +K++ K + D+ Sbjct: 20 DRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAF 79 Query: 389 VEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR-FKEPHAVFYA 447 E + + L+ V E+V GG L + + P A Sbjct: 80 FEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVA 139 Query: 448 AEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGH-------IKIADFG-----MCKENIWDG 495 ++A L +L+ K +++ ++ N++L EG IK++D G + ++ + Sbjct: 140 KQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIER 199 Query: 496 VTTKTFCGTPDYIAPEIIAYQP-YGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSI 553 + +IAPE + + D W+FG L+E+ G+ P + + E + Sbjct: 200 IP---------WIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFY 250 Query: 554 MEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYI--DWEKLERK 611 S KE + M P +R FFR I D KLE + Sbjct: 251 ESRCRPVTPSC-KELADLMTRCMNYDPNQR--------------PFFRAIMRDINKLEEQ 295 Query: 612 E 612 Sbjct: 296 N 296 >4TS6-A nrPDB Length = 132 Score = 125 bits (313), Expect = 8e-29, Method: Composition-based stats. Identities = 34/123 (27%), Positives = 57/123 (46%), Gaps = 4/123 (3%) Query: 160 GRIYIQAHIDREVL--IVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKC 217 GR+ ++ D+ L IV + A L +PY K+ L+PD +SK++TKT+ Sbjct: 10 GRLQLKLGYDQNTLQLIVTLVCATGLSLRQSGAGRNPYAKVFLLPDRSHKSKRRTKTVGT 69 Query: 218 SLNPEWNETFRFQLKE--SDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKAGVDGWF 275 + P W +TF + R L V +WD+ NDF+G + ++ W+ Sbjct: 70 TCEPRWGQTFVYSGLRRCDLNGRLLEVTLWDYVRYGANDFIGEVVIDLAHHILDDEAEWY 129 Query: 276 KLL 278 +L Sbjct: 130 QLQ 132 >2PZI-A nrPDB Length = 681 Score = 125 bits (313), Expect = 9e-29, Method: Composition-based stats. Identities = 67/321 (20%), Positives = 108/321 (33%), Gaps = 37/321 (11%) Query: 287 NVPVPPEGSEGNEELRQKFERAKIGQGTKAPEEKTANTISKFDNNGNRDRMKLTDFNFLM 346 N VP R +G + F N + + Sbjct: 27 NPVVPESKRFCWNCGRPVGRSDSETKGASEGWCPYCGSPYSFLPQLNPGDIVAGQYEVKG 86 Query: 347 VLGKGSFGKVMLSERKG-TDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQ 405 + G G + L+ + +K L V D + + + +R P + Q Sbjct: 87 CIAHGGLGWIYLALDRNVNGRPVVLKGL---VHSGDAEAQAMAMAERQFLAEVVHPSIVQ 143 Query: 406 LHSCFQTMDRL-----YFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSK 460 + + + DR Y VMEYV G L + + A+ Y EI L +L S Sbjct: 144 IFNFVEHTDRHGDPVGYIVMEYVGGQSLKR--SKGQKLPVAEAIAYLLEILPALSYLHSI 201 Query: 461 GIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGK 520 G++Y DLK +N+ML E +K+ D G G GTP + APEI+ P Sbjct: 202 GLVYNDLKPENIMLTEE-QLKLIDLGAVSRINSFGYLY----GTPGFQAPEIVRTGP-TV 255 Query: 521 SVDWWAFGVLLYEMLAGQAP------FEGEDEDELFQSIMEHNVAYPKSMSKEAVA-ICK 573 + D + G L L P +G ED+ P + ++ + + Sbjct: 256 ATDIYTVGRTLA-ALTLDLPTRNGRYVDGLPEDD------------PVLKTYDSYGRLLR 302 Query: 574 GLMTKHPGKRLGCGPEGERDI 594 + P +R E + Sbjct: 303 RAIDPDPRQRFTTAEEMSAQL 323 >4Y12-A nrPDB Length = 375 Score = 124 bits (312), Expect = 1e-28, Method: Composition-based stats. Identities = 67/321 (20%), Positives = 108/321 (33%), Gaps = 37/321 (11%) Query: 287 NVPVPPEGSEGNEELRQKFERAKIGQGTKAPEEKTANTISKFDNNGNRDRMKLTDFNFLM 346 N VP R +G + F N + + Sbjct: 66 NPVVPESKRFCWNCGRPVGRSDSETKGASEGWCPYCGSPYSFLPQLNPGDIVAGQYEVKG 125 Query: 347 VLGKGSFGKVMLSERKG-TDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQ 405 + G G + L+ + +K L V D + + + +R P + Q Sbjct: 126 CIAHGGLGWIYLALDRNVNGRPVVLKGL---VHSGDAEAQAMAMAERQFLAEVVHPSIVQ 182 Query: 406 LHSCFQTMDRL-----YFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSK 460 + + + DR Y VMEYV G L + + A+ Y EI L +L S Sbjct: 183 IFNFVEHTDRHGDPVGYIVMEYVGGQSLKR--SKGQKLPVAEAIAYLLEILPALSYLHSI 240 Query: 461 GIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGK 520 G++Y DLK +N+ML E +K+ D G G GTP + APEI+ P Sbjct: 241 GLVYNDLKPENIMLTEE-QLKLIDLGAVSRINSFGYLY----GTPGFQAPEIVRTGP-TV 294 Query: 521 SVDWWAFGVLLYEMLAGQAP------FEGEDEDELFQSIMEHNVAYPKSMSKEAVA-ICK 573 + D + G L L P +G ED+ P + ++ + + Sbjct: 295 ATDIYTVGRTLA-ALTLDLPTRNGRYVDGLPEDD------------PVLKTYDSYGRLLR 341 Query: 574 GLMTKHPGKRLGCGPEGERDI 594 + P +R E + Sbjct: 342 RAIDPDPRQRFTTAEEMSAQL 362 >1CSN-A nrPDB Length = 298 Score = 124 bits (311), Expect = 1e-28, Method: Composition-based stats. Identities = 47/261 (18%), Positives = 87/261 (33%), Gaps = 27/261 (10%) Query: 334 RDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRV 393 ++ + + +G+GSFG + ++ A+K + D E R Sbjct: 4 QNNVVGVHYKVGRRIGEGSFGVIFEGTNLLNNQQVAIKF-----EPRRSDAPQLRDEYRT 58 Query: 394 LALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR-FKEPHAVFYAAEIAI 452 L + ++ Q V++ + G L + GR F A ++ Sbjct: 59 YKLLAGCTGIPNVYYFGQEGLHNVLVIDLL-GPSLEDLLDLCGRKFSVKTVAMAAKQMLA 117 Query: 453 GLFFLQSKGIIYRDLKLDNVMLDSEGH-----IKIADFGMCKENIWDGVT-------TKT 500 + + K ++YRD+K DN ++ I + DFGM K K Sbjct: 118 RVQSIHEKSLVYRDIKPDNFLIGRPNSKNANMIYVVDFGMVKFYRDPVTKQHIPYREKKN 177 Query: 501 FCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGE---DEDELFQSIMEHN 557 GT Y++ + + D A G + L G P++G + ++ I E Sbjct: 178 LSGTARYMSINTHLGREQSRRDDLEALGHVFMYFLRGSLPWQGLKAATNKQKYERIGEKK 237 Query: 558 VAYP-----KSMSKEAVAICK 573 + P +E Sbjct: 238 QSTPLRELCAGFPEEFYKYMH 258 >1XA6-A nrPDB Length = 466 Score = 124 bits (311), Expect = 1e-28, Method: Composition-based stats. Identities = 33/120 (27%), Positives = 48/120 (40%), Gaps = 6/120 (5%) Query: 15 ESTVRFARKGALRQKNVH--EVKNHKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCF 72 E R+ AL + H K H F F+ P +C +C +F+WG QG +C C Sbjct: 189 EKISSLVRRAALTHNDNHFNYEKTHNFKVHTFRGPHWCEYCANFMWGLIAQGVRCSDCGL 248 Query: 73 VVHKRCHEFVTFSC-PGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGSLLYGLIHQGMK 131 VHK+C + V C P + K H P D C + + +G+K Sbjct: 249 NVHKQCSKHVPNDCQPDLKRIKKVYCCDLTTLVKAHNTQRPMVVDIC---IREIEARGLK 305 Score = 102 bits (254), Expect = 5e-22, Method: Composition-based stats. Identities = 31/95 (32%), Positives = 56/95 (58%), Gaps = 12/95 (12%) Query: 102 HKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGR 161 H FK+HT+ P +C++C + ++GLI QG++C C +NVHK+C +VP+ C D +R + Sbjct: 213 HNFKVHTFRGPHWCEYCANFMWGLIAQGVRCSDCGLNVHKQCSKHVPNDCQPD-LKRIKK 271 Query: 162 IY-------IQAHIDREVLIVVV----RDAKNLVP 185 +Y ++AH + ++V + +A+ L Sbjct: 272 VYCCDLTTLVKAHNTQRPMVVDICIREIEARGLKS 306 >2ELI-A nrPDB Length = 85 Score = 124 bits (311), Expect = 1e-28, Method: Composition-based stats. Identities = 64/77 (83%), Positives = 71/77 (92%) Query: 93 PASDDPRSKHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCG 152 P +DDPRSKHKFKIHTY SPTFCDHCGSLLYGLIHQGMKCDTC MNVHK+CV+NVPSLCG Sbjct: 9 PDTDDPRSKHKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDTCDMNVHKQCVINVPSLCG 68 Query: 153 TDHTERRGRIYIQAHID 169 DHTE+RGRIY++A + Sbjct: 69 MDHTEKRGRIYLKAEVA 85 Score = 89.3 bits (220), Expect = 4e-18, Method: Composition-based stats. Identities = 20/50 (40%), Positives = 25/50 (50%) Query: 37 HKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSC 86 HKF + PTFC HC ++G QG +C C VHK+C V C Sbjct: 18 HKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDTCDMNVHKQCVINVPSLC 67 >6EQI-C nrPDB Length = 433 Score = 123 bits (308), Expect = 3e-28, Method: Composition-based stats. Identities = 59/332 (17%), Positives = 112/332 (33%), Gaps = 73/332 (21%) Query: 326 SKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTD-----ELYAVKIL------- 373 S+ +N L + + + KG V ++ K AVK++ Sbjct: 1 SESENVEQLQAANLDELDLGEPIAKGCNAVVYSAKLKNVQSNKLAHQLAVKMMFNYDVES 60 Query: 374 ----------KKDVVIQDDDVECTMVEKRVLALPGK----PPFLTQLHSCFQTMDR---- 415 ++ V + ++ P + +++S F Sbjct: 61 NSTAILKAMYRETVPAMSYFFNQNLFNIENISDFKIRLPPHPNIVRMYSVFADRIPDLQC 120 Query: 416 -----------------------LYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAI 452 L+ VM+ + L +++ ++ +++ Sbjct: 121 NKQLYPEALPPRINPEGSGRNMSLFLVMKRYDC-TLKEYLRDKTP-NMRSSILLLSQLLE 178 Query: 453 GLFFLQSKGIIYRDLKLDNVMLD-SEG----HIKIADFGMCKENIWDGVTTKTF------ 501 + + I +RDLK DN+++D SEG I I DFG C + +G+ Sbjct: 179 AVAHMNIHNISHRDLKSDNILVDLSEGDAYPTIVITDFGCCLCDKQNGLVIPYRSEDQDK 238 Query: 502 CGTPDYIAPEIIAYQPYG------KSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIME 555 G +APEI +P K D WA G + YE+ PF + L +S E Sbjct: 239 GGNRALMAPEIANAKPGTFSWLNYKKSDLWAVGAIAYEIFNIDNPFYDKTMKLLSKSYKE 298 Query: 556 HNV-AYPKSMSKEAVAICKGLMTKHPGKRLGC 586 ++ P ++ + ++++ KRL C Sbjct: 299 EDLPELPDTIPFIIRNLVSNMLSRSTNKRLDC 330 >1TBN-A nrPDB Length = 82 Score = 122 bits (307), Expect = 4e-28, Method: Composition-based stats. Identities = 56/77 (72%), Positives = 67/77 (87%) Query: 92 GPASDDPRSKHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLC 151 GP +DDPR+KHKF++H+YSSPTFCDHCGSLLYGL+HQGMKC C MNVH+RCV +VPSLC Sbjct: 1 GPQTDDPRNKHKFRLHSYSSPTFCDHCGSLLYGLVHQGMKCSCCEMNVHRRCVRSVPSLC 60 Query: 152 GTDHTERRGRIYIQAHI 168 G DHTERRGR+ ++ Sbjct: 61 GVDHTERRGRLQLEIRA 77 Score = 90.0 bits (222), Expect = 3e-18, Method: Composition-based stats. Identities = 20/50 (40%), Positives = 25/50 (50%) Query: 37 HKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSC 86 HKF + PTFC HC ++G QG +C C VH+RC V C Sbjct: 11 HKFRLHSYSSPTFCDHCGSLLYGLVHQGMKCSCCEMNVHRRCVRSVPSLC 60 >5USZ-A nrPDB Length = 289 Score = 120 bits (301), Expect = 2e-27, Method: Composition-based stats. Identities = 49/268 (18%), Positives = 96/268 (35%), Gaps = 27/268 (10%) Query: 336 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDE-------LYAVKILKKDVVIQDDDVECTM 388 +++ D F LG+G+F K+ R+ + +K+L K + + Sbjct: 4 KIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDK----AHRNYSESF 59 Query: 389 VEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR-FKEPHAVFYA 447 E + L + D V E+V G L ++++ + A Sbjct: 60 FEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVA 119 Query: 448 AEIAIGLFFLQSKGIIYRDLKLDNVML--------DSEGHIKIADFGMCKENIWDGVTTK 499 ++A + FL+ +I+ ++ N++L + IK++D G+ + + + Sbjct: 120 KQLAAAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQE 179 Query: 500 TFCGTPDYIAPEIIAY-QPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIMEHN 557 ++ PE I + + D W+FG L+E+ + G P D Q E Sbjct: 180 RI----PWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFY-EDR 234 Query: 558 VAYPKSMSKEAVAICKGLMTKHPGKRLG 585 P + E + M P R Sbjct: 235 HQLPAPKAAELANLINNCMDYEPDHRPS 262 >2BWQ-A nrPDB Length = 129 Score = 119 bits (298), Expect = 4e-27, Method: Composition-based stats. Identities = 35/125 (28%), Positives = 65/125 (52%), Gaps = 6/125 (4%) Query: 160 GRIYIQAHIDR--EVLIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKC 217 G++ I+ D+ LIV + AK+L + +PYVK+ +PD ++K++TKT+K Sbjct: 5 GQLSIKLWFDKVGHQLIVTILGAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKK 64 Query: 218 SLNPEWNETFRFQ--LKESDKDRRLSVEIWDWDLT--SRNDFMGSLSFGISELQKAGVDG 273 +L P+WN+TF + + ++R L + +WD ++F+G + + Sbjct: 65 TLEPKWNQTFIYSPVHRREFRERMLEITLWDQARVREEESEFLGEILIELETALLDDEPH 124 Query: 274 WFKLL 278 W+KL Sbjct: 125 WYKLQ 129 >5J0A-A nrPDB Length = 300 Score = 119 bits (298), Expect = 5e-27, Method: Composition-based stats. Identities = 49/217 (22%), Positives = 82/217 (37%), Gaps = 24/217 (11%) Query: 344 FLMVLGKGSFGK---VMLSERKGTDELY---AVKILKK--DVVIQDDDVECTMVEKRVLA 395 F+ LG FG V L +R + AVK + + + + M E ++L Sbjct: 13 FMQKLG---FGTGVNVYLMKRSPRGLSHSPWAVKKINPICNDHYRSVYQKRLMDEAKILK 69 Query: 396 LPGKPPFLTQLHSCFQ-TMDRLYFVMEYVNGGDLMYHIQQV-----GRFKEPHAVFYAAE 449 P + + + L MEY L I++ F + A Sbjct: 70 -SLHHPNIVGYRAFTEANDGSLCLAMEYGGEKSLNDLIEERYKASQDPFPAAIILKVALN 128 Query: 450 IAIGLFFLQS-KGIIYRDLKLDNVMLDSEG-HIKIADFGMCKENIWDGVTTKT---FCGT 504 +A GL +L K +++ D+K NV++ + IKI D G+ + T + GT Sbjct: 129 MARGLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMEVTDPEACYIGT 188 Query: 505 PDYIAPEIIAYQPY-GKSVDWWAFGVLLYEMLAGQAP 540 + E + D +AFG+ L+EM+ P Sbjct: 189 EPWKPKEAVEENGVITDKADIFAFGLTLWEMMTLSIP 225 >2ENN-A nrPDB Length = 77 Score = 119 bits (298), Expect = 5e-27, Method: Composition-based stats. Identities = 36/69 (52%), Positives = 48/69 (69%) Query: 22 RKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEF 81 R+GA++Q VH VK H+FTA FF QPTFCS C +F+WG KQG+QC+ C +HK+C + Sbjct: 9 RRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFVWGLNKQGYQCRQCNAAIHKKCIDK 68 Query: 82 VTFSCPGAD 90 V C G+ Sbjct: 69 VIAKCTGSA 77 Score = 80.8 bits (198), Expect = 2e-15, Method: Composition-based stats. Identities = 18/50 (36%), Positives = 27/50 (54%) Query: 102 HKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLC 151 H+F + PTFC C ++GL QG +C C +HK+C+ V + C Sbjct: 24 HEFTATFFPQPTFCSVCHEFVWGLNKQGYQCRQCNAAIHKKCIDKVIAKC 73 >1W15-A nrPDB Length = 153 Score = 116 bits (292), Expect = 2e-26, Method: Composition-based stats. Identities = 41/122 (33%), Positives = 61/122 (50%), Gaps = 4/122 (3%) Query: 159 RGRIYIQAHIDR--EVLIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIK 216 RG + + L VVV A++L D +GLSDPYVK+ L K SK+KT K Sbjct: 16 RGELLVSLCYQSTTNTLTVVVLKARHLPKSDVSGLSDPYVKVNLYHAKKRISKKKTHVKK 75 Query: 217 CSLNPEWNETFRFQLK-ESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKAGVDGWF 275 C+ N +NE F F + ES ++ + + D + SRN+ +G L G + G W Sbjct: 76 CTPNAVFNELFVFDIPCESLEEISVEFLVLDSERGSRNEVIGRLVLGATAEGSGG-GHWK 134 Query: 276 KL 277 ++ Sbjct: 135 EI 136 >3N5A-A nrPDB Length = 138 Score = 115 bits (289), Expect = 5e-26, Method: Composition-based stats. Identities = 40/128 (31%), Positives = 63/128 (49%), Gaps = 4/128 (3%) Query: 159 RGRIYIQAHI--DREVLIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIK 216 RG + + +IV + A+NL MD G SDPYVK+ L+ K K+KT T K Sbjct: 2 RGELLLSLCYNPSANSIIVNIIKARNLKAMDIGGTSDPYVKVWLMYKDKRVEKKKTVTKK 61 Query: 217 CSLNPEWNETFRFQLK-ESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKAGVDGWF 275 +LNP +NE+F F + E ++ + + + D D SRND +G + V W Sbjct: 62 RNLNPIFNESFAFDIPTEKLRETTIIITVMDKDKLSRNDVIGKIYLSWKS-GPGEVKHWK 120 Query: 276 KLLSQEEG 283 ++++ Sbjct: 121 DMIARPRQ 128 >3CXL-A nrPDB Length = 463 Score = 115 bits (289), Expect = 5e-26, Method: Composition-based stats. Identities = 33/122 (27%), Positives = 48/122 (39%), Gaps = 5/122 (4%) Query: 14 EESTVRFARKGALRQKNV--HEVKNHKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCC 71 E+ R+ L++ K H F F+ P +C +C +F+WG QG +C C Sbjct: 185 EKRLTSLVRRATLKENEQIPKYEKIHNFKVHTFRGPHWCEYCANFMWGLIAQGVKCADCG 244 Query: 72 FVVHKRCHEFVTFSCPGADKG-PASDDPRSKHKFKIHTYSSPTFCDHCGSLL--YGLIHQ 128 VHK+C + V C K K HT P D C + GL + Sbjct: 245 LNVHKQCSKMVPNDCKPDLKHVKKVYSCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSE 304 Query: 129 GM 130 G+ Sbjct: 305 GL 306 Score = 93.5 bits (231), Expect = 3e-19, Method: Composition-based stats. Identities = 33/106 (31%), Positives = 58/106 (54%), Gaps = 15/106 (14%) Query: 102 HKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGR 161 H FK+HT+ P +C++C + ++GLI QG+KC C +NVHK+C VP+ C D + + Sbjct: 210 HNFKVHTFRGPHWCEYCANFMWGLIAQGVKCADCGLNVHKQCSKMVPNDCKPD-LKHVKK 268 Query: 162 IY-------IQAHIDREVLIVVV----RDAKNLVPM---DPNGLSD 193 +Y ++AH + ++V + +++ L +G SD Sbjct: 269 VYSCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSEGLYRVSGFSD 314 >1UOW-A nrPDB Length = 159 Score = 114 bits (285), Expect = 1e-25, Method: Composition-based stats. Identities = 45/132 (34%), Positives = 69/132 (52%), Gaps = 4/132 (3%) Query: 152 GTDHTERRGRIYIQAHI--DREVLIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESK 209 G E+ G I L VV+ +AKNL MD GLSDPYVK+ L+ + K K Sbjct: 4 GGGILEKLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKK 63 Query: 210 QKTKTIKCSLNPEWNETFRFQLK-ESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQK 268 +KT K +LNP +NE+F F++ E + ++ V + D+D +ND +G + G + Sbjct: 64 KKTTIKKNTLNPYYNESFSFEVPFEQIQKVQVVVTVLDYDKIGKNDAIGKVFVGYNSTG- 122 Query: 269 AGVDGWFKLLSQ 280 A + W +L+ Sbjct: 123 AELRHWSDMLAN 134 >3FDW-A nrPDB Length = 148 Score = 113 bits (284), Expect = 2e-25, Method: Composition-based stats. Identities = 35/119 (29%), Positives = 56/119 (47%), Gaps = 12/119 (10%) Query: 160 GRIYIQAHIDREV--LIVVVRDAKNLVPMDPNGL-SDPYVKLKLIPDPKSESKQKTKTIK 216 GRI +++ L+V V++ L D S+PYVK L+PD + K+KT + Sbjct: 10 GRIAFSLKYEQQTQSLVVHVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQGKRKTSIKR 69 Query: 217 CSLNPEWNETFRFQLKES-DKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKAGVDGW 274 ++NP ++ET R+++ ES R L +W RN F+G +D W Sbjct: 70 DTVNPLYDETLRYEIPESLLAQRTLQFSVWHHGRFGRNTFLGEAEI--------QMDSW 120 >1UGK-A nrPDB Length = 138 Score = 113 bits (282), Expect = 3e-25, Method: Composition-based stats. Identities = 30/111 (27%), Positives = 65/111 (58%), Gaps = 5/111 (4%) Query: 163 YIQAHIDREVLIVVVRDAKNLVPMDPNGL-SDPYVKLKLIPDPKSESKQKTKTIKCSLNP 221 ++ + +R+ +V +++A+ L MD + SDPY+K+ ++P+ K K KT+ ++ +L+P Sbjct: 14 SLEYNFERKAFVVNIKEARGLPAMDEQSMTSDPYIKMTILPEKKH--KVKTRVLRKTLDP 71 Query: 222 EWNETFRFQLKESDKDRRLSV--EIWDWDLTSRNDFMGSLSFGISELQKAG 270 ++ETF F + + L++ I +D SR+D +G + +S ++ + Sbjct: 72 AFDETFTFYGIPYTQIQELALHFTILSFDRFSRDDIIGEVLIPLSGIELSE 122 >4I94-A nrPDB Length = 300 Score = 113 bits (282), Expect = 4e-25, Method: Composition-based stats. Identities = 47/238 (19%), Positives = 89/238 (37%), Gaps = 18/238 (7%) Query: 355 KVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMD 414 V + + + AVK + D + E + + L C++ + Sbjct: 44 VVYKGKLENQRRI-AVKRFNRKSWP---DSRQFLEEAKAVGQLRNHRMANLLGCCYEDEE 99 Query: 415 RLYFVMEYVNGGDLMYHIQ--QVGRFKEPHAVFYAAEIAIGLFFLQSKG-IIYRDLKLDN 471 RL + E++ L H+ + K + A IA L + SKG +Y DL Sbjct: 100 RL-LIAEFMPNETLAKHLFHWESQPMKWAMRLRVALHIAQALEYCTSKGRALYHDLNAYR 158 Query: 472 VMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLL 531 V+ D + + +++ FG+ K + + TP PE + ++FG LL Sbjct: 159 VLFDDDANPRLSCFGLMKNSRDGKSYSTNLAFTP----PEYLRTGRVTPESVIYSFGTLL 214 Query: 532 YEMLAGQ--APFEGED--EDELFQSIMEHNVA--YPKSMSKEAVAICKGLMTKHPGKR 583 ++L+G+ P D D Q +M+ + + E + + + P +R Sbjct: 215 LDLLSGKHIPPSHALDLIRDRNIQMLMDSGLEGQFSSDDGTELIRLASRCLQYEPRER 272 >6NYT-A nrPDB Length = 148 Score = 112 bits (281), Expect = 4e-25, Method: Composition-based stats. Identities = 40/155 (25%), Positives = 65/155 (41%), Gaps = 37/155 (23%) Query: 139 VHKRCVMNVPSLCGTDHTERRGRIYIQAHIDREVLIVVVRDAKNLVPMDPNGLSDPYVKL 198 K+ V++ GT + + + V A+ L D G SDPYV + Sbjct: 3 AVKQSVLD-----GTSKWSAK-------------ISITVVCAQGLQAKDKTGSSDPYVTV 44 Query: 199 KLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWD---------L 249 ++ ++K++TKTI +LNP W E F F+ S R+ V +WD D Sbjct: 45 QV-----GKTKKRTKTIYGNLNPVWEENFHFECHNSSD--RIKVRVWDEDDDIKSRVKQR 97 Query: 250 TSR--NDFMGSLSFGISELQKAGVDGWFKLLSQEE 282 R +DF+G + L +D W+ L + + Sbjct: 98 FKRESDDFLGQTIIEVRTL-SGEMDVWYNLDKRTD 131 >4XHH-A nrPDB Length = 403 Score = 112 bits (281), Expect = 4e-25, Method: Composition-based stats. Identities = 38/236 (16%), Positives = 84/236 (35%), Gaps = 24/236 (10%) Query: 341 DFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEK-RVLALPGK 399 F +G GSFG + + E A+ + + + + L+ Sbjct: 8 KFRIGRKIGSGSFGDIYHGTNLISGEEVAI---RLESIRSRHPQLDYESRVYKYLSGGVG 64 Query: 400 PPFLTQLHSCFQTMDRLYFVMEYV--NGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFL 457 PF+ + + V++ + + DL + + +F + A ++ + ++ Sbjct: 65 IPFIRWFG---REGEYNAMVIDLLGPSLEDLFNYCHR--KFSFKTVIMLALQMICRVQYI 119 Query: 458 QSKGIIYRDLKLDNVMLD---SEGHIKIADFGMCKENIWDGVTT-------KTFCGTPDY 507 + I+RD+K DN ++ + + DFG+ K+ K+ GT Y Sbjct: 120 HGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTARY 179 Query: 508 IAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEG---EDEDELFQSIMEHNVAY 560 + + D + G +L G P++G + + + I+E + Sbjct: 180 ASVNTHLGIEQSRRDDLESLGYMLIYFCKGSLPWQGLKATTKKQKYDRILEKKLCI 235 >4XHL-A nrPDB Length = 394 Score = 112 bits (280), Expect = 6e-25, Method: Composition-based stats. Identities = 41/234 (17%), Positives = 84/234 (35%), Gaps = 24/234 (10%) Query: 341 DFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEK-RVLALPGK 399 F +G GSFG + + E A+ + + + R L+ Sbjct: 8 KFRIGRKIGSGSFGDIYHGTNLISGEEVAI---RLESIRSRHPQLDYESRVYRYLSGGVG 64 Query: 400 PPFLTQLHSCFQTMDRLYFVMEYV--NGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFL 457 PF+ + + V++ + + DL + + RF + A ++ + ++ Sbjct: 65 IPFIRWFG---REGEYNAMVIDLLGPSLEDLFNYCHR--RFSFKTVIMLALQMFCRIQYI 119 Query: 458 QSKGIIYRDLKLDNVMLD---SEGHIKIADFGMCKENIWDGVTT-------KTFCGTPDY 507 + I+RD+K DN ++ + + DFG+ K+ K+ GT Y Sbjct: 120 HGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTARY 179 Query: 508 IAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEG---EDEDELFQSIMEHNV 558 + + D + G +L G P++G + + + IME + Sbjct: 180 ASVNTHLGIEQSRRDDLESLGYVLIYFCKGSLPWQGLKATTKKQKYDRIMEKKL 233 >5C01-A nrPDB Length = 342 Score = 110 bits (276), Expect = 2e-24, Method: Composition-based stats. Identities = 45/238 (18%), Positives = 85/238 (35%), Gaps = 20/238 (8%) Query: 359 SERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYF 418 +G + +K+L D+ E L L +H Sbjct: 101 GRDRGQELRVVLKVLDP----SHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIM 156 Query: 419 VMEYVNGGDLMYHIQQ-VGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSE 477 V EYV G L +++ G + A ++A L +L++K +++ ++ N++L Sbjct: 157 VTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARL 216 Query: 478 GH-------IKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQ--PYGKSVDWWAFG 528 G IK++D G ++ + ++APE + ++D W FG Sbjct: 217 GLAEGTSPFIKLSDPG----VGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFG 272 Query: 529 VLLYEM-LAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLG 585 L E+ G+AP + E + S + A + +T P +R Sbjct: 273 ATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLAT-LTSQCLTYEPTQRPS 329 >4WOV-A nrPDB Length = 317 Score = 110 bits (276), Expect = 2e-24, Method: Composition-based stats. Identities = 45/238 (18%), Positives = 85/238 (35%), Gaps = 20/238 (8%) Query: 359 SERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYF 418 +G + +K+L D+ E L L +H Sbjct: 78 GRDRGQELRVVLKVLDP----SHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIM 133 Query: 419 VMEYVNGGDLMYHIQQ-VGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSE 477 V EYV G L +++ G + A ++A L +L++K +++ ++ N++L Sbjct: 134 VTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARL 193 Query: 478 GH-------IKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQ--PYGKSVDWWAFG 528 G IK++D G ++ + ++APE + ++D W FG Sbjct: 194 GLAEGTSPFIKLSDPG----VGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFG 249 Query: 529 VLLYEM-LAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLG 585 L E+ G+AP + E + S + A + +T P +R Sbjct: 250 ATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLAT-LTSQCLTYEPTQRPS 306 >2YUU-A nrPDB Length = 83 Score = 110 bits (275), Expect = 2e-24, Method: Composition-based stats. Identities = 30/66 (45%), Positives = 42/66 (63%) Query: 27 RQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSC 86 +Q +H +KNH+F A FF QPTFCS C DF+WG KQG++C+ C +HK+C + + C Sbjct: 8 KQAKIHYIKNHEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRC 67 Query: 87 PGADKG 92 G Sbjct: 68 TGTAAN 73 Score = 84.6 bits (208), Expect = 1e-16, Method: Composition-based stats. Identities = 21/58 (36%), Positives = 29/58 (50%), Gaps = 1/58 (1%) Query: 102 HKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLC-GTDHTER 158 H+F + PTFC C ++GL QG KC C +HK+C+ + C GT R Sbjct: 18 HEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSR 75 >4JRN-A nrPDB Length = 372 Score = 107 bits (267), Expect = 2e-23, Method: Composition-based stats. Identities = 49/274 (17%), Positives = 92/274 (33%), Gaps = 48/274 (17%) Query: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVE---------------KR 392 LG G F V + T+E AVK+ + D+ + E + Sbjct: 76 LGSGGFATVYEATDVETNEELAVKVFMSEKEPTDETMLDLQRESSCYRNFSLAKTAKDAQ 135 Query: 393 VLALPGKPPFLTQLHS-----------CFQTMDRLYFVMEYVNGGDLMYHI--------Q 433 P + L + + + +M D+ I Sbjct: 136 ESCRFMVPSDVVMLEGQPASTEVVIGLTTRWVPNYFLLMMRAEA-DMSKVISWVFGDASV 194 Query: 434 QVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIW 493 F ++ +++ + +Q++GI++ D+K N +L +G + + DFG Sbjct: 195 NKSEFGLVVRMYLSSQAIKLVANVQAQGIVHTDIKPANFLLLKDGRLFLGDFG----TYR 250 Query: 494 DGVTTKTFCGTPDYIAPEI---IAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELF 550 + GTP Y PE Y D W G+ LY + + P D ++ Sbjct: 251 INNSVGRAIGTPGYEPPERPFQATGITYTFPTDAWQLGITLYCIWCKERP---TPADGIW 307 Query: 551 QSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRL 584 + H P + + + + L+ + P KR+ Sbjct: 308 DYL--HFADCPST-PELVQDLIRSLLNRDPQKRM 338 >5YQ3-A nrPDB Length = 162 Score = 106 bits (264), Expect = 4e-23, Method: Composition-based stats. Identities = 31/104 (29%), Positives = 50/104 (48%), Gaps = 5/104 (4%) Query: 171 EVLIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNET--FR 228 +L V + K L D G DPYV+++ + S K + NP WN+ +R Sbjct: 4 GILEVSLISGKGLKRSDFLGKIDPYVEIQYKGQTRKSSVAKEDGGR---NPTWNDKLKWR 60 Query: 229 FQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKAGVD 272 + S D +L V++ D D S +DF+G + + EL + GV+ Sbjct: 61 AEFPGSGADYKLIVKVMDHDTFSSDDFIGEATVHVKELLEMGVE 104 >4L9M-A nrPDB Length = 559 Score = 105 bits (263), Expect = 5e-23, Method: Composition-based stats. Identities = 23/64 (35%), Positives = 34/64 (53%) Query: 37 HKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPASD 96 H F + +PTFC +C F+WG KQG++C+ C HK+C + V F C K P + Sbjct: 494 HNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKDLVVFECKKRAKNPVAP 553 Query: 97 DPRS 100 + Sbjct: 554 TENN 557 Score = 83.5 bits (205), Expect = 3e-16, Method: Composition-based stats. Identities = 24/51 (47%), Positives = 30/51 (58%) Query: 102 HKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCG 152 H F+ TY PTFCD+C L+G+I QG +C C MN HK+C V C Sbjct: 494 HNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKDLVVFECK 544 >5IXC-A nrPDB Length = 814 Score = 104 bits (259), Expect = 1e-22, Method: Composition-based stats. Identities = 47/182 (25%), Positives = 76/182 (41%), Gaps = 11/182 (6%) Query: 172 VLIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQL 231 L V V +A+NL D +DPYV L+L P K KTKT+ + +P WNE FRF + Sbjct: 27 QLTVRVLEARNLRWADLLSEADPYVILQLSTAPGM--KFKTKTLTDTSHPVWNEAFRFLI 84 Query: 232 KESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKAGVDGWFKLLSQEEGEYFNVPVP 291 +S L + I+D D + +D + + ISE+ + S + E +V Sbjct: 85 -QSQVKNVLELSIYDEDSVTEDDICFKVLYDISEVLPGKLLRKTFSQSPQGEEELDVEFL 143 Query: 292 PEGSEGNEELRQKFERAKIGQGTKAPEEKTANTISKFDNNGNRDRMKLTDFNFLMVLGKG 351 E + E + + + D+ G+ + D L ++ KG Sbjct: 144 MEETSDRPE--------NLITNKVIVARELSCLDVHLDSTGSTAVVADQDKLELELVLKG 195 Query: 352 SF 353 S+ Sbjct: 196 SY 197 >3JZY-A nrPDB Length = 510 Score = 104 bits (259), Expect = 2e-22, Method: Composition-based stats. Identities = 29/98 (29%), Positives = 53/98 (54%), Gaps = 6/98 (6%) Query: 173 LIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLK 232 L+V V +A L PNG S+PY ++ + T+TI+ +LNP+WN +F +K Sbjct: 389 LMVHVIEATELKACKPNGKSNPYCEISM-----GSQSYTTRTIQDTLNPKWNFNCQFFIK 443 Query: 233 ESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKAG 270 + +D L + ++D D S +DF+G +++++ Sbjct: 444 DLYQD-VLCLTLFDRDQFSPDDFLGRTEIPVAKIRTEQ 480 >2Q3X-A nrPDB Length = 171 Score = 103 bits (256), Expect = 4e-22, Method: Composition-based stats. Identities = 38/131 (29%), Positives = 61/131 (46%), Gaps = 7/131 (5%) Query: 152 GTDHTERRGRIYIQAHIDREVLIVVVRDAKNLVPMDPNGLSDP--YVKLKLIPDPKSESK 209 T T G I I + L V V A++L P S P YVK+ L+ + +K Sbjct: 11 QTLATPAMGDIQIGMEDKKGQLEVEVIRARSLTQK-PGSKSTPAPYVKVYLLENGACIAK 69 Query: 210 QKTKTIKCSLNPEWNETFRFQLKESDKDRRLSVEIW-DWDLTSRNDFMGSLSFGISELQK 268 +KT+ + +L+P + ++ F ES + + L V +W D+ FMG + EL Sbjct: 70 KKTRIARKTLDPLYQQSLVFD--ESPQGKVLQVIVWGDYGRMDHKCFMGVAQILLEELDL 127 Query: 269 AGV-DGWFKLL 278 + + GW+KL Sbjct: 128 SSMVIGWYKLF 138 >6J6I-B nrPDB Length = 351 Score = 101 bits (252), Expect = 1e-21, Method: Composition-based stats. Identities = 39/186 (20%), Positives = 68/186 (36%), Gaps = 11/186 (5%) Query: 365 DELYAVKILKKDVVI-QDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYV 423 D Y +K +D + + V+ + + A QL C V E+ Sbjct: 81 DRSYMIKRFSEDEITGKRHRVKEVYNDIVLSARMSNHSNFLQLLGCCLEFPFPVLVFEFA 140 Query: 424 NGGDLMYH---IQ--QVGRFKEPHAVFYAAEIAIGLFFLQS---KGIIYRDLKLDNVMLD 475 G + I + + EIA + +L + K II+RD+K +V LD Sbjct: 141 EHGAMNQRGGVIVNGEESLLPWSVRLKIGKEIANAVTYLHTAFPKIIIHRDVKPMHVFLD 200 Query: 476 SEGHIKIAD--FGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYE 533 K++D F + + + GT YI P + D ++FG+ L Sbjct: 201 KNWTAKLSDLSFSISLPEGKSRIEAEWVLGTFGYIDPLYHKTCFVTEYTDVYSFGICLLV 260 Query: 534 MLAGQA 539 ++ G+ Sbjct: 261 IITGKP 266 >2DMG-A nrPDB Length = 142 Score = 100 bits (250), Expect = 2e-21, Method: Composition-based stats. Identities = 36/121 (29%), Positives = 63/121 (52%), Gaps = 5/121 (4%) Query: 161 RIYIQAHIDREVLIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLN 220 ++ I+ R LIVVV +NL+ +G SDPYV++ L+PD + ++KT K +LN Sbjct: 14 QLTIRHSSQRNKLIVVVHACRNLIAFSEDG-SDPYVRMYLLPDKRRSGRRKTHVSKKTLN 72 Query: 221 PEWNETFRFQLKESDKDRR-LSVEIWDWDLTSRNDF--MGSLSFGISELQKA-GVDGWFK 276 P ++++F F + + RR L V + + D +G + ++ + A G W+ Sbjct: 73 PVFDQSFDFSVSLPEVQRRTLDVAVKNSGGFLSKDKGLLGKVLVALASEELAKGWTQWYD 132 Query: 277 L 277 L Sbjct: 133 L 133 >4FKD-A nrPDB Length = 65 Score = 100 bits (249), Expect = 2e-21, Method: Composition-based stats. Identities = 22/55 (40%), Positives = 28/55 (50%) Query: 33 EVKNHKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCP 87 V +H+F +K PTFC HC +WG +QG +C C VH RC V C Sbjct: 6 SVGSHRFKVYNYKSPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTKVANLCE 60 Score = 88.9 bits (219), Expect = 7e-18, Method: Composition-based stats. Identities = 31/50 (62%), Positives = 39/50 (78%) Query: 102 HKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLC 151 H+FK++ Y SPTFC+HCG+LL+GL QG+KCD C MNVH RC V +LC Sbjct: 10 HRFKVYNYKSPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTKVANLC 59 >5A50-A nrPDB Length = 177 Score = 100 bits (248), Expect = 3e-21, Method: Composition-based stats. Identities = 32/99 (32%), Positives = 51/99 (51%), Gaps = 8/99 (8%) Query: 171 EVLIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQ 230 +L + ++ NL D + SDPYV +K+ + K KT+ I +NPEWNE Sbjct: 18 GLLRIRIKRGVNLAVRDISS-SDPYVVVKM-----GKQKLKTRVINKDVNPEWNEDLTLS 71 Query: 231 LKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKA 269 + +S+ L ++D D+ S++D MG F IS +A Sbjct: 72 VTDSNLTVLL--TVYDHDMFSKDDKMGDAEFEISPYIEA 108 >3UEY-A nrPDB Length = 65 Score = 100 bits (248), Expect = 3e-21, Method: Composition-based stats. Identities = 22/55 (40%), Positives = 29/55 (52%) Query: 33 EVKNHKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCP 87 V +H+F + PTFC HC +WG KQG +C+ C VH +C E V C Sbjct: 6 SVGSHRFKVFNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCE 60 Score = 88.1 bits (217), Expect = 1e-17, Method: Composition-based stats. Identities = 31/50 (62%), Positives = 39/50 (78%) Query: 102 HKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLC 151 H+FK+ Y SPTFCDHCGSLL+GL+ QG+KC+ C MNVH +C V +LC Sbjct: 10 HRFKVFNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLC 59 >4L68-A nrPDB Length = 340 Score = 99.3 bits (246), Expect = 4e-21, Method: Composition-based stats. Identities = 34/182 (18%), Positives = 63/182 (34%), Gaps = 13/182 (7%) Query: 364 TDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYV 423 AVK L + + + E L + L L + + V +Y+ Sbjct: 63 DGSALAVKHLSTCKLGERE----FRYEMNQL-WELRHSNLAPLLGFCVVEEEKFLVYKYM 117 Query: 424 NGGDLMYHIQQ-VGRFKEPHAVFYAAEIAIGLFFLQ---SKGIIYRDLKLDNVMLDSEGH 479 + G L + G A GL +L I+++++ +++D + Sbjct: 118 SNGTLHSLLDSNRGELDWSTRFRIGLGAARGLAWLHHGCRPPILHQNICSSVILIDEDFD 177 Query: 480 IKIADFGMCKENIWDGVTTKTFC----GTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEML 535 +I D G+ + + +F G Y+APE D + GV+L E+ Sbjct: 178 ARIIDSGLARLMVPSDNNESSFMTGDLGEFGYVAPEYSTTMLASLKGDVYGLGVVLLELA 237 Query: 536 AG 537 G Sbjct: 238 TG 239 >5A52-A nrPDB Length = 168 Score = 97.0 bits (240), Expect = 3e-20, Method: Composition-based stats. Identities = 30/99 (30%), Positives = 50/99 (50%), Gaps = 8/99 (8%) Query: 171 EVLIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQ 230 +L + V+ NL D + SDPY+ + + K KT+ +K S+NPEWN+ Sbjct: 6 GLLRIHVKRGVNLAIRDISS-SDPYIVVHC-----GKQKLKTRVVKHSVNPEWNDDLTLS 59 Query: 231 LKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKA 269 + + + +L ++D+DL S +D MG F I +A Sbjct: 60 VTDPNLPIKL--TVYDYDLLSADDKMGEAEFHIGPFIEA 96 >2ENZ-A nrPDB Length = 65 Score = 96.6 bits (239), Expect = 3e-20, Method: Composition-based stats. Identities = 21/50 (42%), Positives = 26/50 (52%) Query: 37 HKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSC 86 H+F +K PTFC HC +WG +QG +C C VH RC V C Sbjct: 13 HRFKVYNYKSPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTKVANLC 62 Score = 95.0 bits (235), Expect = 1e-19, Method: Composition-based stats. Identities = 33/65 (50%), Positives = 43/65 (66%) Query: 90 DKGPASDDPRSKHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPS 149 +S H+FK++ Y SPTFC+HCG+LL+GL QG+KCD C MNVH RC V + Sbjct: 1 GSSGSSGKIDMPHRFKVYNYKSPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTKVAN 60 Query: 150 LCGTD 154 LCG + Sbjct: 61 LCGIN 65 >4P42-A nrPDB Length = 474 Score = 95.4 bits (236), Expect = 7e-20, Method: Composition-based stats. Identities = 35/145 (24%), Positives = 69/145 (47%), Gaps = 14/145 (9%) Query: 147 VPSLCGTDHTERRGRIYIQAHIDREVLIVVVRDAKNLVPMD------PNGLSDPYVKLKL 200 +P+ ++ + + VL + +A++L D G SDPY +++ Sbjct: 173 LPNRITVPLVSEVQIAQLRFPVPKGVLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRV 232 Query: 201 IPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLS 260 +++ IK +L+P+WNE + + E + L +E++D D ++DF+GSL Sbjct: 233 -----GNQIFQSRVIKENLSPKWNEVYEALVYEH-PGQELEIELFDED-PDKDDFLGSLM 285 Query: 261 FGISELQKAG-VDGWFKLLSQEEGE 284 + E++K +D WF L +G+ Sbjct: 286 IDLIEVEKERLLDEWFTLDEVPKGK 310 Score = 49.2 bits (116), Expect = 6e-06, Method: Composition-based stats. Identities = 23/103 (22%), Positives = 43/103 (41%), Gaps = 10/103 (9%) Query: 169 DREVLIVVVRDAKNLVP-MDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETF 227 +LI+ + A+NL + +P V++ + Q++K + P W E F Sbjct: 346 SSALLILYLDSARNLPSGKKISSNPNPVVQMSV-----GHKAQESKIRYKTNEPVWEENF 400 Query: 228 RFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKAG 270 F + K + L VE+ D +G+L +S+L + Sbjct: 401 TFFIHNP-KRQDLEVEVRDE---QHQCSLGNLKVPLSQLLTSE 439 >4NPK-A nrPDB Length = 299 Score = 93.5 bits (231), Expect = 3e-19, Method: Composition-based stats. Identities = 34/129 (26%), Positives = 66/129 (51%), Gaps = 14/129 (10%) Query: 163 YIQAHIDREVLIVVVRDAKNLVPMD------PNGLSDPYVKLKLIPDPKSESKQKTKTIK 216 ++ + + VL + +A++L D G SDPY +++ +++ IK Sbjct: 16 QLRFPVPKGVLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRV-----GNQIFQSRVIK 70 Query: 217 CSLNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKAG-VDGWF 275 +L+P+WNE + + E + L +E++D D ++DF+GSL + E++K +D WF Sbjct: 71 ENLSPKWNEVYEALVYEH-PGQELEIELFDED-PDKDDFLGSLMIDLIEVEKERLLDEWF 128 Query: 276 KLLSQEEGE 284 L +G+ Sbjct: 129 TLDEVPKGK 137 Score = 48.4 bits (114), Expect = 9e-06, Method: Composition-based stats. Identities = 23/103 (22%), Positives = 43/103 (41%), Gaps = 10/103 (9%) Query: 169 DREVLIVVVRDAKNLVP-MDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETF 227 +LI+ + A+NL + +P V++ + Q++K + P W E F Sbjct: 173 SSALLILYLDSARNLPSGKKISSNPNPVVQMSV-----GHKAQESKIRYKTNEPVWEENF 227 Query: 228 RFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKAG 270 F + K + L VE+ D +G+L +S+L + Sbjct: 228 TFFIHNP-KRQDLEVEVRDE---QHQCSLGNLKVPLSQLLTSE 266 >1Y8F-A nrPDB Length = 66 Score = 92.0 bits (227), Expect = 7e-19, Method: Composition-based stats. Identities = 15/51 (29%), Positives = 23/51 (45%) Query: 37 HKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCP 87 H F PT+C C +WG +QG +C C H++C + + C Sbjct: 14 HNFEVWTATTPTYCYECEGLLWGIARQGMRCTECGVKCHEKCQDLLNADCK 64 Score = 76.9 bits (188), Expect = 2e-14, Method: Composition-based stats. Identities = 18/54 (33%), Positives = 33/54 (61%) Query: 101 KHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTD 154 +H F++ T ++PT+C C LL+G+ QGM+C C + H++C + + C + Sbjct: 13 QHNFEVWTATTPTYCYECEGLLWGIARQGMRCTECGVKCHEKCQDLLNADCKLN 66 >5UV4-A nrPDB Length = 311 Score = 90.8 bits (224), Expect = 2e-18, Method: Composition-based stats. Identities = 38/205 (18%), Positives = 78/205 (38%), Gaps = 17/205 (8%) Query: 346 MVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQ 405 ++G+ G + + VK LK+ + E + L + P L Sbjct: 31 EIIGRSCHGTSYKATL-DNGYMLTVKWLKEGFAKSKKE---FSREIKKLGSV-RHPNLVP 85 Query: 406 L--HSCFQTMDRLYFVMEYVNGGDLMYHI-----QQVGRFKEPHAVFYAAEIAIGLFFLQ 458 L + + +Y + L ++ + + + A +IA L +L Sbjct: 86 LRGYYWGPKEHERIMISDYADATSLSTYLSEFDERNLPPLSAGQRLNIAIDIARCLDYLH 145 Query: 459 SKGII-YRDLKLDNVML-DSEGHIKIADFGMCKENIWDGVTTKTF-CGTPDYIAPEIIAY 515 ++ +I + ++K NV++ +S + D+ + + G+ + G Y PE + Sbjct: 146 NERVIPHGNIKSSNVLIQNSTPSALVTDYSLHRLMTPIGMAEQVLNAGALGYSPPEFSST 205 Query: 516 QPY--GKSVDWWAFGVLLYEMLAGQ 538 D +AFGV+L E+L G+ Sbjct: 206 SKPCPSLKSDVYAFGVILLELLTGK 230 >5UU1-A nrPDB Length = 324 Score = 89.3 bits (220), Expect = 5e-18, Method: Composition-based stats. Identities = 49/239 (20%), Positives = 87/239 (36%), Gaps = 24/239 (10%) Query: 327 KFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYA---VKI----------- 372 F D M+ + +G G FG + L+ E A VK+ Sbjct: 3 PFPEGKVLDDMEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSE 62 Query: 373 LKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHI 432 LK + D +E++ L G P F + F+ + VME + G DL Sbjct: 63 LKFYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERL-GIDLQKIS 121 Query: 433 QQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLD--SEGHIKIADFGMCKE 490 Q G FK+ + + L ++ ++ D+K N++L + + +AD+G+ Sbjct: 122 GQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYR 181 Query: 491 NIWDGVT-------TKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFE 542 +G K GT ++ + + + D G + L G+ P+E Sbjct: 182 YCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWE 240 >5CLR-A nrPDB Length = 451 Score = 88.9 bits (219), Expect = 6e-18, Method: Composition-based stats. Identities = 47/236 (19%), Positives = 85/236 (36%), Gaps = 28/236 (11%) Query: 357 MLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRL 416 + Y +K +K D + + EK L+ G+ + + F ++ Sbjct: 96 FKVYALDDGKTYFLKSVKIDA----ESLTEFTNEKDTLSKLGR-----LVGTFFNEQTQV 146 Query: 417 -YFVMEYVNGGDLMYHIQQVGRFKEP-----HAVFYAAEIAIGLFFLQSKGIIYRDLKLD 470 Y + ++ G DL + + + + + G+I+RDLK Sbjct: 147 HYILTTFIKGIDLSRY-KNALPLNVNLKHFWEVLGIMISVCHQVKQFHELGLIHRDLKPG 205 Query: 471 NVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQP---YGKSVDWWAF 527 N+MLD++ + DFG D GT Y+APE+ A + + + D +A Sbjct: 206 NIMLDADMQCHLVDFGSS---SSDKEPKPASWGTASYLAPELNAQEDFIAFSQVSDLFAL 262 Query: 528 GVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKR 583 L E+ PF ++ I ++ + E A GLM+ R Sbjct: 263 AYSLDELFN---PFRQVKFAKVDIGIKNKHLVL---LHAEIEACITGLMSNETSVR 312 >4RJ9-A nrPDB Length = 165 Score = 88.5 bits (218), Expect = 8e-18, Method: Composition-based stats. Identities = 29/96 (30%), Positives = 45/96 (46%), Gaps = 9/96 (9%) Query: 171 EVLIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQ 230 ++ V V NL D SDPYV +++ + K KT+ IK + NPEWN+ Sbjct: 7 GLVKVRVVRGVNLAVRDLRS-SDPYVIVRM-----GKQKLKTRVIKKTTNPEWNDELTLS 60 Query: 231 LKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISEL 266 +++ RL ++D D +D MG+ I L Sbjct: 61 IEDPAVPVRLE--VYDKDTF-IDDAMGNAELDIRPL 93 >4IX6-A nrPDB Length = 350 Score = 82.3 bits (202), Expect = 6e-16, Method: Composition-based stats. Identities = 59/330 (17%), Positives = 104/330 (31%), Gaps = 73/330 (22%) Query: 337 MKLTDFNFL-MVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 395 ++ D L LG G+FG V KG D+ +K K DV+ ++ +EC M + Sbjct: 16 VEPKDIRVLPGPLGSGNFGTVFRGVFKG-DQDVVLKNAKADVMAAEELLECEM-DVNYHV 73 Query: 396 LPGKPPFLTQLHSCFQ----TMDRLY--FVME---YV---NGGDLMYHIQQVGRFKEPHA 443 + C + +Y + E + G + + + + G A Sbjct: 74 HANAKGTCARFMGCIELGAKDGGEIYNGTLTEGLWLMWANEGENTVEALMRRGTAPLATA 133 Query: 444 VFY------------AAEIAIGLFFLQSKGIIYRDLKLDNVMLDSE--GHIKIADFGMCK 489 + E+ L L G+++RD+K N++ + G +K+ D G Sbjct: 134 MACADATELGVTKKAMRELLGSLARLHECGVVHRDVKPANLIAAEKDGGVLKLIDLGAAA 193 Query: 490 ENIWDGVTTKTFCG----TPDYI-APEIIAYQPYGKSV-----------------DWWAF 527 + T + G P Y A E+ P D W+ Sbjct: 194 LCLPLPETLNYYPGDGPADPRYAKADELYLLPPGSPRPTKDNAAKLWEAHKPDRFDSWSA 253 Query: 528 GVLLYEMLA-------GQAPFEGE-----DEDELFQSIMEHNVAYPKSMSKEA-----VA 570 G ++ ++ G F + + F+ + +A Sbjct: 254 GCVMLQLAVVGLRTDAGLERFLADYKAVGYDVNAFRGEKSGEYGTMDFAALDANGGAGWD 313 Query: 571 ICKGLMTKHPGKRLGCGPEGERDIKEHAFF 600 +C+ LM R C HAFF Sbjct: 314 LCQRLMEAERDARASC-----EAALSHAFF 338 >4O1O-A nrPDB Length = 717 Score = 80.4 bits (197), Expect = 2e-15, Method: Composition-based stats. Identities = 42/254 (16%), Positives = 76/254 (29%), Gaps = 54/254 (21%) Query: 365 DELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVN 424 D+ AVK + +V C L + + L+ + Sbjct: 369 DQEVAVKRFSEGSTRGQQEVSC-------LQSSRANDNVVTFYGSESDGSCLHVCLALCE 421 Query: 425 GGDLMYHIQQVG-----RFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGH 479 L H+ ++ A + + + L G ++DL+ N+++DS+ Sbjct: 422 Y-TLQEHLANHRGDAVPNEEDESARNILSSLFKAIGELHRSGYSHQDLQPQNILIDSKNG 480 Query: 480 IKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFG-VLLYEMLAGQ 538 +ADF + D K D A G ++LY + G Sbjct: 481 TFLADFDKSIKWAEDPQKIKR----------------------DLEALGLLVLYVVKKGD 518 Query: 539 APFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTK--HPGKRLGCGPEGERDIKE 596 FE F+ +++ + +E + L + RL + Sbjct: 519 ISFETLKNQS-FEEVIQGSPD------EETRDLIHHLFHPGDNVEDRLSS-------LLA 564 Query: 597 HAFFRYIDWEKLER 610 H FF WE R Sbjct: 565 HPFF--WSWESRYR 576 >1RLW-A nrPDB Length = 126 Score = 77.7 bits (190), Expect = 2e-14, Method: Composition-based stats. Identities = 26/108 (24%), Positives = 51/108 (47%), Gaps = 7/108 (6%) Query: 169 DREVLIVVVRDAKNLVPM---DPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNE 225 VVV A + D DPYV+L + P +S+++T+ +NP WNE Sbjct: 1 SSHKFTVVVLRATKVTKGAFGDMLDTPDPYVELFISTTP--DSRKRTRHFNNDINPVWNE 58 Query: 226 TFRFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKAGVDG 273 TF F + + +++ L + + D + ++ +G+ +F +S ++ Sbjct: 59 TFEF-ILDPNQENVLEITLMDANYV-MDETLGTATFTVSSMKVGEKKE 104 >5DMZ-A nrPDB Length = 365 Score = 77.3 bits (189), Expect = 2e-14, Method: Composition-based stats. Identities = 41/269 (15%), Positives = 94/269 (34%), Gaps = 41/269 (15%) Query: 347 VLGKGSFGKVMLSE-----RKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 +LG+G+F +V + + + +K+ +K + + ++E+ L + Sbjct: 72 LLGEGAFAQVYEATQGDLNDAKNKQKFVLKV-QKPANPWEFYIGTQLMER--LKPSMQHM 128 Query: 402 FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEP-----HAVFYAAEIAIGLFF 456 F+ + +S + V E + G L+ I E + +A + + Sbjct: 129 FM-KFYSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEKVMPQGLVISFAMRMLYMIEQ 187 Query: 457 LQSKGIIYRDLKLDNVML--------DSEGH---IKIADFGMCK--ENIWDGVTTKTFCG 503 + II+ D+K DN +L D + + + D G + G C Sbjct: 188 VHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMKLFPKGTIFTAKCE 247 Query: 504 TPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQA--------------PFEGEDEDEL 549 T + E+++ +P+ +D++ +Y ML G F ++ Sbjct: 248 TSGFQCVEMLSNKPWNYQIDYFGVAATVYCMLFGTYMKVKNEGGECKPEGLFRRLPHLDM 307 Query: 550 FQSIMEHNVAYPKSMSKEAVAICKGLMTK 578 + + P ++ + + + K Sbjct: 308 WNEFFHVMLNIPDCHHLPSLDLLRQKLKK 336 >1BCI-A nrPDB Length = 138 Score = 76.5 bits (187), Expect = 3e-14, Method: Composition-based stats. Identities = 27/115 (23%), Positives = 54/115 (46%), Gaps = 8/115 (6%) Query: 162 IYIQAHIDREVLIVVVRDAKNLVPM---DPNGLSDPYVKLKLIPDPKSESKQKTKTIKCS 218 I ++ VVV A + D DPYV+L + P +S+++T+ Sbjct: 10 IIVEHQYS-HKFTVVVLRATKVTKGAFGDMLDTPDPYVELFISTTP--DSRKRTRHFNND 66 Query: 219 LNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKAGVDG 273 +NP WNETF F + + +++ L + + D + ++ +G+ +F +S ++ Sbjct: 67 INPVWNETFEF-ILDPNQENVLEITLMDANYV-MDETLGTATFTVSSMKVGEKKE 119 >3BJI-A nrPDB Length = 378 Score = 76.2 bits (186), Expect = 4e-14, Method: Composition-based stats. Identities = 19/58 (32%), Positives = 29/58 (50%), Gaps = 1/58 (1%) Query: 95 SDDPRSKHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCG 152 + + H F++ ++ T C C LL G +QG +C C + HK C+ VP CG Sbjct: 321 ENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCRASAHKECLGRVPP-CG 377 Score = 48.8 bits (115), Expect = 7e-06, Method: Composition-based stats. Identities = 15/48 (31%), Positives = 20/48 (41%) Query: 36 NHKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVT 83 H F F++ T C C + G QG++C C HK C V Sbjct: 327 GHDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCRASAHKECLGRVP 374 >1CJY-A nrPDB Length = 749 Score = 76.2 bits (186), Expect = 5e-14, Method: Composition-based stats. Identities = 27/115 (23%), Positives = 54/115 (46%), Gaps = 8/115 (6%) Query: 162 IYIQAHIDREVLIVVVRDAKNLVPM---DPNGLSDPYVKLKLIPDPKSESKQKTKTIKCS 218 I ++ VVV A + D DPYV+L + P +S+++T+ Sbjct: 10 IIVEHQYS-HKFTVVVLRATKVTKGAFGDMLDTPDPYVELFISTTP--DSRKRTRHFNND 66 Query: 219 LNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKAGVDG 273 +NP WNETF F + + +++ L + + D + ++ +G+ +F +S ++ Sbjct: 67 INPVWNETFEF-ILDPNQENVLEITLMDANYV-MDETLGTATFTVSSMKVGEKKE 119 >3KY9-A nrPDB Length = 587 Score = 76.2 bits (186), Expect = 5e-14, Method: Composition-based stats. Identities = 19/58 (32%), Positives = 29/58 (50%), Gaps = 1/58 (1%) Query: 95 SDDPRSKHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCG 152 + + H F++ ++ T C C LL G +QG +C C + HK C+ VP CG Sbjct: 512 ENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCRASAHKECLGRVPP-CG 568 Score = 50.4 bits (119), Expect = 3e-06, Method: Composition-based stats. Identities = 17/68 (25%), Positives = 24/68 (35%) Query: 36 NHKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPAS 95 H F F++ T C C + G QG++C C HK C V P + Sbjct: 518 GHDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCRASAHKECLGRVPPCGRHGQDFPGT 577 Query: 96 DDPRSKHK 103 H+ Sbjct: 578 MKKDKLHR 585 >6EAS-A nrPDB Length = 308 Score = 75.8 bits (185), Expect = 5e-14, Method: Composition-based stats. Identities = 39/235 (16%), Positives = 73/235 (31%), Gaps = 38/235 (16%) Query: 380 QDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRL-YFVMEYVNGGDLMYHI--QQVG 436 ++ + L+ F+ L C + V EY G L H+ ++ Sbjct: 81 SKENESQYRKKITNLSKVSHKNFMNLLGYCEEEHPFTRVMVFEYAPNGTLFEHLHVREAE 140 Query: 437 RFKEPHAVFYAAEIAIGLFFLQSKGI--IYRDLKLDNVMLDSEGHIKIADFGMCKENIWD 494 + + + IA L + R+ V L + K++D + Sbjct: 141 KLDWMARLRISMGIAYCLEHMHQLQTPAALRNFDSTTVYLTDDFAAKVSDLEFWNDAKGH 200 Query: 495 GVTTKTFCGTPDYIAP--EIIAYQPYGKSVDWWAFGVLLYEMLAGQAP------------ 540 TT +P E I + +G++L E+L G+ P Sbjct: 201 NSTTNNELAF----SPDMEDIVRK----------YGMVLLEILTGRVPSSEDDGPLENWV 246 Query: 541 ---FEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGER 592 FEG L + I +P+ ++ + + + + P KR R Sbjct: 247 SRYFEG--GMRLEELIDPSIGFFPEDTARALCEVVRSCIDRDPKKRPQMKEVAAR 299 >2RSV-A nrPDB Length = 403 Score = 73.8 bits (180), Expect = 2e-13, Method: Composition-based stats. Identities = 42/270 (15%), Positives = 96/270 (35%), Gaps = 40/270 (14%) Query: 341 DFNFLMVLGKGSFGKVMLS-----ERKGTDELYAVKI-------LKKDVVIQDDDVECTM 388 ++ + +G+G FG + L+ E G+D VK+ L ++ + Sbjct: 43 EWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQ 102 Query: 389 VEKRVLALPGKPPFLTQLHSCFQTMD----RLYFVMEYVNGGDLMYHIQ-QVGRFKEPHA 443 ++K + K + + + +M+ G DL + RF Sbjct: 103 IQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIYEANAKRFSRKTV 161 Query: 444 VFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLD--SEGHIKIADFGMC---------KENI 492 + + I L ++ ++ D+K N++L+ + + + D+G+ KE Sbjct: 162 LQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYK 221 Query: 493 WDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQS 552 D GT ++ + + + D G + + L G P+ ED + + Sbjct: 222 EDPKRCHD--GTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPW--EDNLKDPKY 277 Query: 553 IMEHNVAYPKSMSKEAVAICKGLMTKHPGK 582 + + + Y +++ ++ P K Sbjct: 278 VRDSKIRYRENI----ASLMDKCF---PEK 300 >6G4J-A nrPDB Length = 315 Score = 73.8 bits (180), Expect = 2e-13, Method: Composition-based stats. Identities = 38/156 (24%), Positives = 57/156 (36%), Gaps = 25/156 (16%) Query: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401 + LGKG+ G V L+E +D A+K+ DD E VL K Sbjct: 28 YTLRKQLGKGANGIVYLAE--TSDGHVALKV--------SDDSLSITSEVNVLKSFSKAQ 77 Query: 402 FLTQLHSCFQTMDRLYF----------VMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIA 451 + F D Y MEY+ G L+ ++ G ++ Sbjct: 78 S-VTMGPSFFDTDDAYIPSANTKVSFYAMEYIKGPLLLKYVSDKGA---EWIPVLMIQLL 133 Query: 452 IGLFFLQSKGIIYRDLKLDNVMLDS-EGHIKIADFG 486 L L +G I+ DLK DN+++ I+ D G Sbjct: 134 SSLSVLHQQGWIFGDLKPDNLIVTGPPARIRCIDVG 169 >2LAV-A nrPDB Length = 361 Score = 73.8 bits (180), Expect = 2e-13, Method: Composition-based stats. Identities = 42/270 (15%), Positives = 96/270 (35%), Gaps = 40/270 (14%) Query: 341 DFNFLMVLGKGSFGKVMLS-----ERKGTDELYAVKI-------LKKDVVIQDDDVECTM 388 ++ + +G+G FG + L+ E G+D VK+ L ++ + Sbjct: 36 EWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQ 95 Query: 389 VEKRVLALPGKPPFLTQLHSCFQTMD----RLYFVMEYVNGGDLMYHIQ-QVGRFKEPHA 443 ++K + K + + + +M+ G DL + RF Sbjct: 96 IQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIYEANAKRFSRKTV 154 Query: 444 VFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLD--SEGHIKIADFGMC---------KENI 492 + + I L ++ ++ D+K N++L+ + + + D+G+ KE Sbjct: 155 LQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYK 214 Query: 493 WDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQS 552 D GT ++ + + + D G + + L G P+ ED + + Sbjct: 215 EDPKRCHD--GTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPW--EDNLKDPKY 270 Query: 553 IMEHNVAYPKSMSKEAVAICKGLMTKHPGK 582 + + + Y +++ ++ P K Sbjct: 271 VRDSKIRYRENI----ASLMDKCF---PEK 293 >2VRW-B nrPDB Length = 406 Score = 73.1 bits (178), Expect = 4e-13, Method: Composition-based stats. Identities = 19/58 (32%), Positives = 28/58 (48%), Gaps = 1/58 (1%) Query: 95 SDDPRSKHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCG 152 + + H F++ ++ T C C LL G +QG +C C HK C+ VP CG Sbjct: 340 ENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCYRCRAPAHKECLGRVPP-CG 396 Score = 47.7 bits (112), Expect = 2e-05, Method: Composition-based stats. Identities = 15/48 (31%), Positives = 20/48 (41%) Query: 36 NHKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVT 83 H F F++ T C C + G QG++C C HK C V Sbjct: 346 GHDFQMFSFEETTSCKACQMLLRGTFYQGYRCYRCRAPAHKECLGRVP 393 >4OAU-C nrPDB Length = 699 Score = 71.5 bits (174), Expect = 1e-12, Method: Composition-based stats. Identities = 45/255 (17%), Positives = 75/255 (29%), Gaps = 55/255 (21%) Query: 365 DELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVN 424 + AVK + E L + L + L+ + Sbjct: 366 KQEVAVKTFCEGSP-------RAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCE 418 Query: 425 G---GDLMYHIQQVGRFKEPH-AVFYAAEIAIGLFFLQ-SKGIIYRDLKLDNVMLDSEGH 479 L H + +E A + I + L S G ++DL+ N+++DS+ Sbjct: 419 QTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKA 478 Query: 480 IKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFG-VLLYEMLAGQ 538 +ADF + + A P D G ++LY + G Sbjct: 479 AHLADF----------------DKSIKW------AGDPQEVKRDLEDLGRLVLYVVKKGS 516 Query: 539 APFEG---EDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIK 595 FE + +E+ Q S +E + L R + D+ Sbjct: 517 ISFEDLKAQSNEEVVQL----------SPDEETKDLIHRLFHPGEHVR-----DCLSDLL 561 Query: 596 EHAFFRYIDWEKLER 610 H FF WE R Sbjct: 562 GHPFF--WTWESRYR 574 >6M7Z-A nrPDB Length = 319 Score = 70.0 bits (170), Expect = 4e-12, Method: Composition-based stats. Identities = 32/216 (14%), Positives = 79/216 (36%), Gaps = 41/216 (18%) Query: 416 LYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLD 475 L ++ ++ G + ++ P AA + L L + G+++R ++L++ + Sbjct: 121 LTYIFHPLSKGLVGDMLETGR--SHPDVQVLAANMVAALKSLHNLGLLHRSIELNSFSVL 178 Query: 476 SEGHIKIADFGMCKENIWDGVTTKTFCGTPDYI-------APEI---------IAYQPYG 519 +G + + G+ T ++ APEI + + Sbjct: 179 PDGTVVLG--GL-------DTAAPIGTETRLWVGFFGQETAPEIDRNFLADLALTQGRHT 229 Query: 520 KSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKH 579 D ++ GV ++ Q G E ++ + ++ +S + ++ + Sbjct: 230 VKSDVYSLGVAFRNLV--QLLGNGNLGPEDRGAVRQDHLELLDKLS-------QKMIEEE 280 Query: 580 PGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQP 615 PG R +I + F +++E +E + +P Sbjct: 281 PGNRPTI-----EEIMKDPLFEGLNFEDIEEGKARP 311 >1DJX-A nrPDB Length = 624 Score = 69.2 bits (168), Expect = 5e-12, Method: Composition-based stats. Identities = 28/129 (21%), Positives = 55/129 (42%), Gaps = 4/129 (3%) Query: 144 VMNVPSLCGTDHTERRGRIYIQAHIDREVLIVVVRDAKNLVPMDPNGLS--DPYVKLKLI 201 V+ L + T + E L V + + L ++ N S DP V +++ Sbjct: 470 VLKPAFLRDPNTTFNSRALTQGPWWRPERLRVRIISGQQLPKVNKNKNSIVDPKVIVEIH 529 Query: 202 PDPKSESKQKTKTIKCS-LNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLS 260 + ++T I + NP W+ F F++ D + + D+D +S+NDF+G + Sbjct: 530 GVGRDTGSRQTAVITNNGFNPRWDMEFEFEVTVPDLA-LVRFMVEDYDSSSKNDFIGQST 588 Query: 261 FGISELQKA 269 + L++ Sbjct: 589 IPWNSLKQG 597 >6BHC-A nrPDB Length = 438 Score = 65.0 bits (157), Expect = 9e-11, Method: Composition-based stats. Identities = 46/273 (16%), Positives = 87/273 (31%), Gaps = 51/273 (18%) Query: 368 YAVKILKKDVVIQDDD------VECTMVEKRVLALPGK-----PPFLTQLHS-CFQTMDR 415 YAVKI K + V + G P L + Sbjct: 86 YAVKICKSKAKESQQYYHSLAVRQSLAVHFNIQQDCGHFLAEVPNRLLPWEDPSKKQRSH 145 Query: 416 LYFVMEYVNGGDLMYHIQ-------QVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLK 468 + + V + ++ + E ++ GL L+ + + DL+ Sbjct: 146 VVVITREVPCLTVADFVRDSLAQHGKSPDLYERQVCLLLLQLCSGLEHLKPYHVTHCDLR 205 Query: 469 LDNVMLDS---------------------EGHIKIADFGMCKE--NIWDGVTTKTFCGTP 505 L+N++L + +++F K+ ++ D + Sbjct: 206 LENLLLVHYQPGGTAQGFGPAEPTPTSSYPTRLIVSNFSQAKQKSHLVDPEILRDQSR-- 263 Query: 506 DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYP--KS 563 +APEII Y K D + G+L+YEML PF+ E + + P Sbjct: 264 --LAPEIITATQY-KKCDEFQTGILIYEMLHLPNPFDENPELKEREYTRADLPRIPFRSP 320 Query: 564 MSKEAVAICKGLMTKHPGKRLGCGPEGERDIKE 596 S+ + L+ +P +R+ + I + Sbjct: 321 YSRGLQQLASCLLNPNPSERILIS--DAKGILQ 351 >4CI6-B nrPDB Length = 643 Score = 61.5 bits (148), Expect = 1e-09, Method: Composition-based stats. Identities = 40/180 (22%), Positives = 64/180 (35%), Gaps = 24/180 (13%) Query: 362 KGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHS--CFQTMDRLY-- 417 K L A KI + + + K + GK P L +H +R Y Sbjct: 66 KDKQRLVA-KI--ERSIAEGHLFAELEAYKHIYKTAGKHPNLANVHGMAVVPYGNRYYYA 122 Query: 418 FVMEYVNG-------GDLMYHIQQVGRFKEP---HAVFYAAEIAIGLFFLQSKGIIYRDL 467 +M+ V+G L +Q E F A + L GI++ D+ Sbjct: 123 LLMDEVDGWRCSDTLRSLADSWKQGKINSEAYWGTIKFIAHRLLDVTNHLAKAGIVHNDI 182 Query: 468 KLDNVMLD-SEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEI-IAYQPYGKSVDWW 525 K NV+ D + G + D G+ + G K F T + APE+ + + D + Sbjct: 183 KPGNVVFDRASGEPVVIDLGL---HSRSGEQPKGF--TESFKAPELGVGNLGASEKSDVF 237 >6EWX-A nrPDB Length = 484 Score = 61.1 bits (147), Expect = 1e-09, Method: Composition-based stats. Identities = 40/192 (20%), Positives = 65/192 (33%), Gaps = 45/192 (23%) Query: 440 EPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEG--------------------- 478 E F ++ GL L+ GII+RDL L+N++L Sbjct: 209 ERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLVHCNPQSSPGPSANPSVPTTTSRCP 268 Query: 479 --------------------HIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY 518 + I++F + + G T + +APEI++ Y Sbjct: 269 SAAPAATTACQGGPGEKHLPRLIISNF-LKAKQKPGGTTNLQQKKSQARLAPEIVSASQY 327 Query: 519 GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYP--KSMSKEAVAICKGLM 576 + D + G+L+YE+L PFE + E P S + L+ Sbjct: 328 -RKFDEFQTGILIYELLHQPNPFEVRAQLRERDYRREDLPPLPTLSLYSPGLQQLAHLLL 386 Query: 577 TKHPGKRLGCGP 588 P KR+ G Sbjct: 387 EADPIKRIRIGE 398 >2DB6-A nrPDB Length = 74 Score = 58.4 bits (140), Expect = 9e-09, Method: Composition-based stats. Identities = 22/59 (37%), Positives = 28/59 (47%), Gaps = 1/59 (1%) Query: 35 KNHKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFV-TFSCPGADKG 92 K HKF FFK+P FC C I K G +C+ C +H+ C +V C G G Sbjct: 16 KPHKFKDHFFKKPKFCDVCARMIVLNNKFGLRCKNCKTNIHEHCQSYVEMQRCSGPSSG 74 Score = 51.1 bits (121), Expect = 2e-06, Method: Composition-based stats. Identities = 19/61 (31%), Positives = 27/61 (44%) Query: 87 PGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMN 146 G+ P HKFK H + P FCD C ++ G++C C N+H+ C Sbjct: 3 SGSSGEPPKLVNDKPHKFKDHFFKKPKFCDVCARMIVLNNKFGLRCKNCKTNIHEHCQSY 62 Query: 147 V 147 V Sbjct: 63 V 63 >2JII-A nrPDB Length = 352 Score = 56.1 bits (134), Expect = 4e-08, Method: Composition-based stats. Identities = 19/132 (14%), Positives = 47/132 (35%), Gaps = 11/132 (8%) Query: 438 FKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLD--SEGHIKIADFGMCKENIWDG 495 E + A + L FL ++ ++ +N+ +D + + +A +G G Sbjct: 156 LSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVDPEDQSQVTLAGYGFAFRYCPSG 215 Query: 496 VTTKTFCGTP-------DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDE 548 G+ ++I+ ++ + D + G + + L G P+ + Sbjct: 216 KHVAYVEGSRSPHEGDLEFISMDLHKGCGPSRRSDLQSLGYCMLKWLYGFLPWTNCLPNT 275 Query: 549 LFQSIMEHNVAY 560 + IM+ + Sbjct: 276 --EDIMKQKQKF 285 >5GZA-A nrPDB Length = 290 Score = 55.7 bits (133), Expect = 6e-08, Method: Composition-based stats. Identities = 40/217 (18%), Positives = 72/217 (33%), Gaps = 50/217 (23%) Query: 343 NFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPF 402 + ++G+G+ KV LSE + + A+ +L D D + + + Sbjct: 28 RRVKLIGQGAVKKVYLSEWQ--GQKVALSVLSSDQYADD------FLHGLSMLRALQSSH 79 Query: 403 LTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQ--VGRFKEPHAVFYAAEIAIG----LFF 456 + L + FV EY G ++ R++ ++ ++AI L + Sbjct: 80 VVTLVGVCEEDA--VFVTEYHPLGSVLTLDTTLAQERYRWRNSWHTRLQLAIDYVAFLAY 137 Query: 457 LQSKGIIYR------DLK--LDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCG----- 503 L S R DL L +L S+ + + + K G Sbjct: 138 LHSSPAGIRVMCDSNDLHKTLSQFLLASDMRL------LANDLDALPEVEKGGLGVKCGH 191 Query: 504 ---TPDYIAPEII------------AYQPYGKSVDWW 525 T D++APE + A Y + D W Sbjct: 192 HELTGDFVAPEQLWPYGEDFSFSDEAMPGYDEKTDIW 228 >3NSJ-A nrPDB Length = 540 Score = 54.2 bits (129), Expect = 2e-07, Method: Composition-based stats. Identities = 26/125 (20%), Positives = 45/125 (36%), Gaps = 8/125 (6%) Query: 135 CMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDREVLIVVVRDAKNLVPMDPNGLSDP 194 C HK + C + Q + L+V A++L D +D Sbjct: 360 CRSGQHKSSHDSCQCECQDSKVTNQDCCPRQRGLAH--LVVSNFRAEHL-WGDYTTATDA 416 Query: 195 YVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSRND 254 Y+K+ + +T + + NP W + F+ L V++WD D +D Sbjct: 417 YLKVFF-----GGQEFRTGVVWNNNNPRWTDKMDFENVLLSTGGPLRVQVWDADYGWDDD 471 Query: 255 FMGSL 259 +GS Sbjct: 472 LLGSC 476 >4AZW-A nrPDB Length = 471 Score = 53.4 bits (127), Expect = 3e-07, Method: Composition-based stats. Identities = 19/70 (27%), Positives = 32/70 (45%), Gaps = 3/70 (4%) Query: 417 YFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDS 476 + VME + G L + +E + L L+ KG + D++ NVM+D+ Sbjct: 318 WLVMEKLPGRLLSDMLAAG---EEIDREKILGSLLRSLAALEKKGFWHDDVRPWNVMVDA 374 Query: 477 EGHIKIADFG 486 H ++ DFG Sbjct: 375 RQHARLIDFG 384 >4AZV-A nrPDB Length = 569 Score = 53.4 bits (127), Expect = 3e-07, Method: Composition-based stats. Identities = 18/70 (25%), Positives = 32/70 (45%), Gaps = 3/70 (4%) Query: 417 YFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDS 476 + VME + G L + +E + L L+ +G + D++ NVM+D+ Sbjct: 318 WLVMEKLPGRLLSDMLAAG---EEIDREKILGSLLRSLAALEKQGFWHDDVRPWNVMVDA 374 Query: 477 EGHIKIADFG 486 H ++ DFG Sbjct: 375 RQHARLIDFG 384 >5GZ9-A nrPDB Length = 305 Score = 52.3 bits (124), Expect = 7e-07, Method: Composition-based stats. Identities = 39/217 (17%), Positives = 68/217 (31%), Gaps = 41/217 (18%) Query: 339 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 398 T+ L +G+G+ +V LSE K A+ + + + E + ++L Sbjct: 33 RTEVRQLKRVGEGAVKRVFLSEWKE--HKVAL-----SRLTRLEMKEDFLHGLQMLKSLQ 85 Query: 399 KPPFLTQLHSCFQTMDRLYFVMEYVNGGDL------MYHIQQVGRFKEPHAVFYAAEIAI 452 +T + C + + EY G L + + H + A E Sbjct: 86 SEHVVTLVGYCEEDGT---ILTEYHPLGSLSNLEETLQLSKYQDVNTWQHRLQLAMEYVS 142 Query: 453 GLFFLQSKGIIYR------DL--KLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGT 504 + +L + R DL L +L S I D + CG Sbjct: 143 IINYLHHSPLGTRVMCDSNDLPKTLSQYLLTSNFSIVANDLD-ALPLVDHDSGVLIKCGH 201 Query: 505 PD----YIAPEII------------AYQPYGKSVDWW 525 + ++APE + Y + VD W Sbjct: 202 RELHGDFVAPEQLWPYGEDTPFQDDLMPSYNEKVDIW 238 >4CYJ-A nrPDB Length = 438 Score = 51.9 bits (123), Expect = 9e-07, Method: Composition-based stats. Identities = 24/148 (16%), Positives = 49/148 (33%), Gaps = 21/148 (14%) Query: 353 FGK---VMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSC 409 FG V ++ YA++ L+ + + + M + + + + +H Sbjct: 65 FGYPSWVYKAQNSRNGRHYALRRLEGYRLTNEKAILNVMKDWKKIKNAS----IVTIHEV 120 Query: 410 FQT----MDRLYFVMEYVNGG-DLMYH---------IQQVGRFKEPHAVFYAAEIAIGLF 455 F T L F ++ L H + E Y +IA L Sbjct: 121 FTTREFGDSSLIFAYDFHPLSKTLQEHHFQPIHGNRYRPPPAVPENTIWGYICQIANALK 180 Query: 456 FLQSKGIIYRDLKLDNVMLDSEGHIKIA 483 + S + R L+ ++L I+++ Sbjct: 181 TIHSNRLAARCLEPSKIILTDINRIRLS 208 >4CZY-B nrPDB Length = 429 Score = 51.5 bits (122), Expect = 1e-06, Method: Composition-based stats. Identities = 20/142 (14%), Positives = 49/142 (34%), Gaps = 20/142 (14%) Query: 357 MLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTM--- 413 ++ +A++ ++ + + + E + + + +H F T Sbjct: 61 YKAQNNKNGRHFALRRIEGYRLTNEKAILNVTKEWKKIINA----NIVTVHEAFTTEFFG 116 Query: 414 -DRLYFVMEYVNGGD-LMYH----------IQQVGRFKEPHAVFYAAEIAIGLFFLQSKG 461 L FV ++ + L H ++ + E Y +IA L + + Sbjct: 117 DSSLIFVYDFHPLSETLYDHHFPPNNSHNRLRNTNKIPENLLWSYVCQIANALLAIHNAK 176 Query: 462 IIYRDLKLDNVMLDSEGHIKIA 483 + R L+L ++ I++A Sbjct: 177 LAARCLELSKIIW-ENNRIRLA 197 >2W1Z-A nrPDB Length = 368 Score = 51.1 bits (121), Expect = 1e-06, Method: Composition-based stats. Identities = 49/299 (16%), Positives = 96/299 (32%), Gaps = 65/299 (21%) Query: 342 FNFLMVLGK--------------GSFGKVMLSERKGTDELY--------------AVKIL 373 F LG+ GS+ + + + T E A+K L Sbjct: 47 FRVESELGERPRTLVRGPVLRDDGSY-ICLEATDQETGEPLEVHVPYFTERPPSNAIKQL 105 Query: 374 KKDVVIQD--DDVECTMVEKRVLAL-----PGKPPFLTQLHSCFQTMDRLYFV------- 419 + V+ ++ K L K P ++ ++ + Sbjct: 106 SEQVLRLRLLRGIKNQRQAKAYLRFIFPIDLVKDPKKRKMIRVRLDERDMWVLSRFFLYP 165 Query: 420 -ME--YVNGGD-LMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLD 475 M+ GD L+ H + ++ LQ G+++ D ++ N++LD Sbjct: 166 RMQSNLHILGDVLLSHSSTHKSLVHHARLQLTLQLIRLAASLQHYGLVHADFQVRNILLD 225 Query: 476 SEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPE-----IIAYQPY-----GKSVDWW 525 G + + F + + DG + + G + PE ++ Y+ + D W Sbjct: 226 QRGGVFLTGF---EHLVRDGASAVSPIG-RGFAPPETTAERMLPYRQHHPTLMTFPFDTW 281 Query: 526 AFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRL 584 G+ +Y + P ED I E K++ + A+ +G + RL Sbjct: 282 TLGLAIYWIWCADLP---NTEDAELGGI-EWIYRRCKNIPQPVRALLEGFLRYSKEDRL 336 >2DMH-A nrPDB Length = 140 Score = 48.8 bits (115), Expect = 8e-06, Method: Composition-based stats. Identities = 29/121 (23%), Positives = 50/121 (41%), Gaps = 11/121 (9%) Query: 169 DREVLIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFR 228 +L V+V A N+ G DP V + + K + LNP WNE Sbjct: 5 SSGMLRVIVESASNIPKTKF-GKPDPIVSVIFKDEKKKTK-----KVDNELNPVWNEILE 58 Query: 229 FQLK--ESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKAGVDGW-FKLLS--QEEG 283 F L+ D L + + D++ +N +G+ + + +L +KL+S E+G Sbjct: 59 FDLRGIPLDFSSSLGIIVKDFETIGQNKLIGTATVALKDLTGDQSRSLPYKLISLLNEKG 118 Query: 284 E 284 + Sbjct: 119 Q 119 >3BYV-A nrPDB Length = 377 Score = 47.3 bits (111), Expect = 2e-05, Method: Composition-based stats. Identities = 29/168 (17%), Positives = 61/168 (36%), Gaps = 19/168 (11%) Query: 428 LMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGM 487 L+ H + ++ L L G+++ L+ +++LD G + + F Sbjct: 193 LLSHSSTHKSLVHHARLQLTLQVIRLLASLHHYGLVHTYLRPVDIVLDQRGGVFLTGF-- 250 Query: 488 CKENIWDGVTTKTFCGTPDYIAPEIIAYQ---PY--------GKSVDWWAFGVLLYEMLA 536 + + DG + + + PE+ A + Y S D WA G+++Y + Sbjct: 251 -EHLVRDGARVVSSV-SRGFEPPELEARRATISYHRDRRTLMTFSFDAWALGLVIYWIWC 308 Query: 537 GQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRL 584 P + + I K++ + A+ +G + RL Sbjct: 309 ADLPITKDAALGGSEWIFRSC----KNIPQPVRALLEGFLRYPKEDRL 352 >3ENH-A nrPDB Length = 540 Score = 46.9 bits (110), Expect = 3e-05, Method: Composition-based stats. Identities = 46/240 (19%), Positives = 84/240 (35%), Gaps = 39/240 (16%) Query: 277 LLSQEEGEYFNVPVPPEGSEGNEELRQKFERAKIGQGTKAPEEKTANTISKFDNNGNRDR 336 L + EG+ + VPP+ G+ A +G + +K N D Sbjct: 268 LKAMCEGQNVDFYVPPKEFCGDNGAM----IAWLGLLMHKNGRWMSLDETKIIPNYRTDM 323 Query: 337 MKLTDFNFLM---------VLGKGSFGKVMLSERKGTDELYAVK-ILKK----DVVIQDD 382 +++ + ++GKG+ + + D +K +KK + + ++ Sbjct: 324 VEVNWIKEIKGKKRKIPEHLIGKGA--EADIKRDSYLDFDVIIKERVKKGYRDERLDENI 381 Query: 383 DVECTMVEKRVLALPGK----PPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRF 438 T E R LAL P++ R+ M Y+NG I+ Sbjct: 382 RKSRTAREARYLALVKDFGIPAPYI---FDVDLDNKRIM--MSYINGKLAKDVIEDN--- 433 Query: 439 KEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTT 498 + A +I + L +I+ DL N + D + + I DFG+ K + D Sbjct: 434 -----LDIAYKIGEIVGKLHKNDVIHNDLTTSNFIFDKDLY--IIDFGLGKISNLDEDKA 486 >5VE6-A nrPDB Length = 492 Score = 46.5 bits (109), Expect = 4e-05, Method: Composition-based stats. Identities = 14/35 (40%), Positives = 21/35 (60%) Query: 440 EPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVML 474 E F ++ GL L+ GII+RDL L+N++L Sbjct: 207 ERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLL 241 Score = 42.6 bits (99), Expect = 5e-04, Method: Composition-based stats. Identities = 22/83 (26%), Positives = 34/83 (40%), Gaps = 3/83 (3%) Query: 508 IAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYP--KSMS 565 +APEI++ Y + D + G+L+YE+L PFE + E P S Sbjct: 325 LAPEIVSASQY-RKFDEFQTGILIYELLHQPNPFEVRAQLRERDYRQEDLPPLPALSLYS 383 Query: 566 KEAVAICKGLMTKHPGKRLGCGP 588 + L+ P KR+ G Sbjct: 384 PGLQQLAHLLLEADPIKRIRIGE 406 >4WWA-A nrPDB Length = 261 Score = 45.7 bits (107), Expect = 6e-05, Method: Composition-based stats. Identities = 25/150 (16%), Positives = 51/150 (34%), Gaps = 21/150 (14%) Query: 357 MLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVL-------ALPGKPPFLT-QLHS 408 L K + + Y +K + + ++ + + R L L P QL + Sbjct: 38 YLPRAKDSHQKYIIKY-RPPKRYRHPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIA 96 Query: 409 CFQTMDRLYFVM--EYVNGG----DLMYHI--QQVGRFKEPHAVFYAAEIAIGLFFLQSK 460 C ++ E + GG +L + + + A ++ + L Sbjct: 97 CDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTL-RKVGRQIGLLHWN 155 Query: 461 GIIYRDLKLDNVMLDSEG---HIKIADFGM 487 + DL N++L +G + DFG+ Sbjct: 156 DYCHGDLTSSNIVLVRDGARWTPHLIDFGL 185 >5YK0-A nrPDB Length = 452 Score = 45.3 bits (106), Expect = 9e-05, Method: Composition-based stats. Identities = 39/225 (17%), Positives = 68/225 (30%), Gaps = 41/225 (18%) Query: 299 EELRQKFERAKIGQGTKAPEEKTANTISKFDNN-GNRDRMKLTDFNFLMVLGKGSFGKVM 357 +E + + A AP + D G + R + + FN V S G+V Sbjct: 91 DEFGEPYREALTKLQKDAPPLPASKVHRVLDGQLGTKWRERFSSFNDTPV-ASASIGQVH 149 Query: 358 LSERKGTDELYAVKI--------LKKDVVIQDD---------------DVECTMVEKRVL 394 + AVKI L+ D+ V +VE+ + Sbjct: 150 KAIW-SDGREVAVKIQYPGADEALRADLKTMQRMVGVLKQLSPGADVQGVVDELVERTEM 208 Query: 395 ALPGKPP--FLTQLHSCFQTMDRL-----------YFVMEYVNGGDLMYHIQQVGRFKEP 441 L + + R + E++ G + I+ + Sbjct: 209 ELDYRLEAANQRAFAKAYHDHPRFQVPHVVASAPKVVIQEWIEGVPMAEIIRHGTTEQRD 268 Query: 442 HAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFG 486 AE+ + G+++ D N ML +G + I DFG Sbjct: 269 LIGTLLAELT--FDAPRRLGLMHGDAHPGNFMLLPDGRMGIIDFG 311 >3DZO-A nrPDB Length = 413 Score = 45.3 bits (106), Expect = 9e-05, Method: Composition-based stats. Identities = 29/167 (17%), Positives = 62/167 (37%), Gaps = 18/167 (10%) Query: 428 LMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGM 487 L+ H + ++ L L G+++ L+ +++LD G + + F Sbjct: 198 LLSHSSTHKSLVHHARLQLTLQVIRLLASLHHYGLVHTYLRPVDIVLDQRGGVFLTGF-- 255 Query: 488 CKENIWDGVTTKTFCGTPDYIAPE-----IIAYQPY-----GKSVDWWAFGVLLYEMLAG 537 + + DG + + G + PE ++ + + + D W G+ +Y + Sbjct: 256 -EHLVRDGASAVSPIG-RGFAPPETTAERMLPFGQHHPTLMTFAFDTWTLGLAIYWIWCA 313 Query: 538 QAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRL 584 P D+ L S E K++ + A+ +G + RL Sbjct: 314 DLP--NTDDAALGGS--EWIFRSCKNIPQPVRALLEGFLRYPKEDRL 356 >2FNF-X nrPDB Length = 72 Score = 45.0 bits (105), Expect = 1e-04, Method: Composition-based stats. Identities = 12/53 (22%), Positives = 18/53 (33%), Gaps = 4/53 (7%) Query: 35 KNHKF-TARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSC 86 + H+F P +C C +Q +C C F H C + C Sbjct: 22 EGHRFVELALRGGPGWCDLCGR---EVLRQALRCANCKFTCHSECRSLIQLDC 71 Score = 42.3 bits (98), Expect = 7e-04, Method: Composition-based stats. Identities = 13/51 (25%), Positives = 22/51 (43%), Gaps = 4/51 (7%) Query: 102 HKF-KIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLC 151 H+F ++ P +CD CG ++ Q ++C C H C + C Sbjct: 24 HRFVELALRGGPGWCDLCG---REVLRQALRCANCKFTCHSECRSLIQLDC 71 >6G38-A nrPDB Length = 357 Score = 44.2 bits (103), Expect = 2e-04, Method: Composition-based stats. Identities = 31/178 (17%), Positives = 51/178 (28%), Gaps = 49/178 (27%) Query: 340 TDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVV-----IQDDDVECTMVEKRVL 394 +G+G FG+V + T A+KI+ + E + E + Sbjct: 41 EKLQRCEKIGEGVFGEVFQTIADHT--PVAIKIIAIEGPDLVNGSHQKTFEEILPEIIIS 98 Query: 395 A-------------------------LPGKPPFLTQLHSC-------------FQTMDRL 416 PP L + F D+L Sbjct: 99 KELSLLSGEVCNRTEGFIGLNSVHCVQGSYPPLLLKAWDHYNSTKGSANDRPDFFKDDQL 158 Query: 417 YFVMEYVNGG-DLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQ-SKGIIYRDLKLDNV 472 + V+E+ GG DL ++ A ++ L + S +RDL NV Sbjct: 159 FIVLEFEFGGIDLEQMRTKLSSL--ATAKSILHQLTASLAVAEASLRFEHRDLHWGNV 214 >2ZKM-X nrPDB Length = 799 Score = 43.8 bits (102), Expect = 2e-04, Method: Composition-based stats. Identities = 24/102 (23%), Positives = 37/102 (36%), Gaps = 12/102 (11%) Query: 172 VLIVVVRDAKNLVPMDPNGLSDPYVKLKLIP---DPKSESKQKTKTIKCSLNPEWNET-F 227 L + V + L YV+++L DPK + K S+NP W E F Sbjct: 679 TLSITVISGQFLSERSVRT----YVEVELFGLPGDPKRRYRTKLSPSTNSINPVWKEEPF 734 Query: 228 RFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKA 269 F+ + L V + + N F+G I+ L Sbjct: 735 VFEKILMPELASLRVAVMEEG----NKFLGHRIIPINALNSG 772 >3Q60-A nrPDB Length = 371 Score = 41.1 bits (95), Expect = 0.002, Method: Composition-based stats. Identities = 24/152 (15%), Positives = 52/152 (34%), Gaps = 18/152 (11%) Query: 446 YAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTP 505 A++ LQSKG+++ DN+ + +G + + D + + T Sbjct: 199 LTAQLIRLAANLQSKGLVHGHFTPDNLFIMPDGRLMLGDV-SALWKVGTRGPASSVPVT- 256 Query: 506 DYIAP-EIIAYQ--PYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPK 562 AP E + + +++ W G+ +Y + PF G + S ++ P Sbjct: 257 --YAPREFLNASTATFTHALNAWQLGLSIYRVWCLFLPF-GLVTPGIKGSWKRPSLRVPG 313 Query: 563 S----------MSKEAVAICKGLMTKHPGKRL 584 + + + + +RL Sbjct: 314 TDSLAFGSCTPLPDFVKTLIGRFLNFDRRRRL 345 >6EI6-A nrPDB Length = 270 Score = 40.7 bits (94), Expect = 0.002, Method: Composition-based stats. Identities = 37/232 (15%), Positives = 85/232 (36%), Gaps = 44/232 (18%) Query: 93 PASDDPRSKHKFKIHTYSS--PT--FCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVP 148 P S + F I + PT C+ + L Q M C H + + +V Sbjct: 10 PPSQRDNLEASFAIVSAEECDPTDDICEIGVRMEEQLAKQLMMCK--NTRDHHKAMGDVA 67 Query: 149 SLCGTDHT--------------ERRGRIYIQAHIDREVLIVVVRDAKNLVPMDPN----- 189 + ++ +R+ + H ++ + V +L + Sbjct: 68 GMNRFENLALTVQKDLDLVRYSKRKNEPLPKFHYEKRSFNI-VHCNTDLTDSELEIVVVR 126 Query: 190 GLS---------DPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRR- 239 G+S D YV+++ K KT I+ + +P+++E F+ ++ +++ + Sbjct: 127 GISYNVANPKDVDTYVRVEFPLLNDESFKTKTNVIRDTSSPDYDERFKVDIQRTNRQFQR 186 Query: 240 ------LSVEIWDWDLTSRNDF-MGSLSFGISELQ-KAGVDGWFKLLSQEEG 283 + EI+ R+D +G+++ + L+ K + + L+ + Sbjct: 187 IFKRHGVKFEIYSRGGFLRSDTLIGTVNVKLQPLETKCEIHDTYDLMDGRKQ 238 >3QR1-A nrPDB Length = 813 Score = 40.3 bits (93), Expect = 0.003, Method: Composition-based stats. Identities = 20/102 (19%), Positives = 41/102 (40%), Gaps = 8/102 (7%) Query: 170 REVLIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCS-LNPEWNET-F 227 + + + A+ L + + V++ +P K KTKT+ + ++P +NE F Sbjct: 649 AGTIEIKIISAQFLSDKQISSYVE--VEMYGLPTDTVRKKFKTKTVNNNGMDPYYNENAF 706 Query: 228 RFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKA 269 F+ K D + I + D F+G + ++ Sbjct: 707 VFK-KVVLPDLAVVRIIVNEDGGK---FIGHRLMPLDGIKPG 744 >2CJT-A nrPDB Length = 131 Score = 40.0 bits (92), Expect = 0.004, Method: Composition-based stats. Identities = 21/107 (19%), Positives = 44/107 (41%), Gaps = 15/107 (14%) Query: 180 AKNLVPMDPNG---LSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDK 236 + +G + YV LK+ ++ + T P W + F F++ D Sbjct: 8 CVGVKKAKFDGAQEKFNTYVTLKV------QNVKSTTIAVRGSQPSWEQDFMFEINRLDL 61 Query: 237 DRRLSVEIWDWDLTSRNDFMGSLSFGISELQKAGVD---GWFKLLSQ 280 L+VE+W+ L + +G++ + ++++ + W L SQ Sbjct: 62 G--LTVEVWNKGLIW-DTMVGTVWIPLRTIRQSNEEGPGEWLTLDSQ 105 >4B6D-A nrPDB Length = 61 Score = 38.4 bits (88), Expect = 0.009, Method: Composition-based stats. Identities = 15/54 (27%), Positives = 23/54 (42%), Gaps = 1/54 (1%) Query: 33 EVKNHKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSC 86 ++ H F ++ +P C C I FGK +C+ C V H C + C Sbjct: 5 SMRLHDFVSKTVIKPESCVPCGKRI-KFGKLSLKCRDCRVVSHPECRDRCPLPC 57 Score = 38.0 bits (87), Expect = 0.013, Method: Composition-based stats. Identities = 14/50 (28%), Positives = 17/50 (34%), Gaps = 1/50 (2%) Query: 102 HKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLC 151 H F T P C CG + +KC C + H C P C Sbjct: 9 HDFVSKTVIKPESCVPCGKRIK-FGKLSLKCRDCRVVSHPECRDRCPLPC 57 >6FDN-A nrPDB Length = 320 Score = 38.4 bits (88), Expect = 0.010, Method: Composition-based stats. Identities = 22/74 (29%), Positives = 37/74 (50%), Gaps = 6/74 (8%) Query: 412 TMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDN 471 +R VME +NG Y + Q+ ++P +V+ E + L + G+I+ D N Sbjct: 180 DYNRHAVVMELING----YPLCQIHHVEDPASVY--DEAMELIVKLANHGLIHGDFNEFN 233 Query: 472 VMLDSEGHIKIADF 485 ++LD HI + DF Sbjct: 234 LILDESDHITMIDF 247 >6G18-v nrPDB Length = 552 Score = 38.4 bits (88), Expect = 0.010, Method: Composition-based stats. Identities = 22/74 (29%), Positives = 37/74 (50%), Gaps = 6/74 (8%) Query: 412 TMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDN 471 +R VME +NG Y + Q+ ++P +V+ E + L + G+I+ D N Sbjct: 180 DYNRHAVVMELING----YPLCQIHHVEDPASVY--DEAMELIVKLANHGLIHGDFNEFN 233 Query: 472 VMLDSEGHIKIADF 485 ++LD HI + DF Sbjct: 234 LILDESDHITMIDF 247 >2CJS-A nrPDB Length = 167 Score = 38.4 bits (88), Expect = 0.011, Method: Composition-based stats. Identities = 21/107 (19%), Positives = 44/107 (41%), Gaps = 15/107 (14%) Query: 180 AKNLVPMDPNG---LSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDK 236 + +G + YV LK+ ++ + T P W + F F++ D Sbjct: 17 CVGVKKAKFDGAQEKFNTYVTLKV------QNVESTTIAVRGSQPSWEQDFMFEINRLDL 70 Query: 237 DRRLSVEIWDWDLTSRNDFMGSLSFGISELQKAGVD---GWFKLLSQ 280 L+VE+W+ L + +G++ + ++++ + W L SQ Sbjct: 71 G--LTVEVWNKGLIW-DTMVGTVWIPLRTIRQSNEEGPGEWLTLDSQ 114 >4QJ3-B nrPDB Length = 793 Score = 38.0 bits (87), Expect = 0.012, Method: Composition-based stats. Identities = 21/102 (20%), Positives = 39/102 (38%), Gaps = 9/102 (8%) Query: 170 REVLIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDP-KSESKQKTKTIK-CSLNPEWNETF 227 L V V + L YV++ + P + K +T+T + S NP W+E Sbjct: 627 ANALRVKVISGQFLSDRKVGI----YVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEE- 681 Query: 228 RFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKA 269 F + S+ I ++ + F+G +S ++ Sbjct: 682 PFDFPKVVLPTLASLRIAAFEEGGK--FVGHRILPVSAIRSG 721 >3OHM-B nrPDB Length = 885 Score = 38.0 bits (87), Expect = 0.013, Method: Composition-based stats. Identities = 21/102 (20%), Positives = 39/102 (38%), Gaps = 9/102 (8%) Query: 170 REVLIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDP-KSESKQKTKTIK-CSLNPEWNETF 227 L V V + L YV++ + P + K +T+T + S NP W+E Sbjct: 724 ANALRVKVISGQFLSDRKVGI----YVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEE- 778 Query: 228 RFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKA 269 F + S+ I ++ + F+G +S ++ Sbjct: 779 PFDFPKVVLPTLASLRIAAFEEGGK--FVGHRILPVSAIRSG 818 >1TQM-A nrPDB Length = 282 Score = 38.0 bits (87), Expect = 0.015, Method: Composition-based stats. Identities = 30/152 (19%), Positives = 53/152 (34%), Gaps = 19/152 (12%) Query: 344 FLMVLGKGSFGKVMLSERKGTDELYAVKILK------KDVVIQDDDVECTMVEKRVLALP 397 ++G+G V + E VK K K V + D + + + Sbjct: 94 IGKLMGEGKESAVFNCYSEKFGECV-VKFHKVGHTSFKKVKEKRDYGDLHFSVLAIRSAR 152 Query: 398 GKPPFLTQLHSCFQTMDRLY----FVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIG 453 + L +L + +ME ++ +L + + E+A Sbjct: 153 NEFRALQKLQGLAVPKVYAWEGNAVLMELIDAKELYRVRVEN---PDEVLDMILEEVAK- 208 Query: 454 LFFLQSKGIIYRDLKLDNVMLDSEGHIKIADF 485 F +GI++ DL NV++ EG I I DF Sbjct: 209 --FYH-RGIVHGDLSQYNVLVSEEG-IWIIDF 236 >2ROW-A nrPDB Length = 84 Score = 36.9 bits (84), Expect = 0.028, Method: Composition-based stats. Identities = 13/49 (26%), Positives = 19/49 (38%), Gaps = 2/49 (4%) Query: 35 KNHKFTARFFKQPTFCSHCTDFIWGFGK--QGFQCQVCCFVVHKRCHEF 81 K H+F + PT C C +W K +C+ C HK + Sbjct: 23 KGHEFIPTLYHFPTNCEACMKPLWHMFKPPPALECRRCHIKCHKDHMDK 71 Score = 35.7 bits (81), Expect = 0.071, Method: Composition-based stats. Identities = 12/47 (25%), Positives = 20/47 (42%), Gaps = 2/47 (4%) Query: 102 HKFKIHTYSSPTFCDHCGSLLYGLIH--QGMKCDTCMMNVHKRCVMN 146 H+F Y PT C+ C L+ + ++C C + HK + Sbjct: 25 HEFIPTLYHFPTNCEACMKPLWHMFKPPPALECRRCHIKCHKDHMDK 71 >3QR0-A nrPDB Length = 816 Score = 36.5 bits (83), Expect = 0.038, Method: Composition-based stats. Identities = 15/102 (14%), Positives = 40/102 (39%), Gaps = 8/102 (7%) Query: 170 REVLIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCS-LNPEWNET-F 227 + + + A+ L + + V++ +P K KTK I+ + ++P ++E F Sbjct: 649 AGTIEIKIISAQFLSDKQISSYVE--VEMYGLPTDTVRKKFKTKIIENNGMDPYYDEKVF 706 Query: 228 RFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKA 269 F+ + + + + + F+G + ++ Sbjct: 707 VFKKVVLPDLAVVRIIVSEENGK----FIGHRVMPLDGIKPG 744 >2QEN-A nrPDB Length = 350 Score = 34.2 bits (77), Expect = 0.19, Method: Composition-based stats. Identities = 37/176 (21%), Positives = 64/176 (36%), Gaps = 39/176 (22%) Query: 335 DRMKLTDFN---FLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEK 391 D +K+TD+ + + G+ ++ K T + LK+ + DV +E+ Sbjct: 179 DFLKITDYESPLYGRIAGE----VLVKPFDKDTSVEF----LKRGFREVNLDVPENEIEE 230 Query: 392 RVLALPGKPPFLTQLHSCFQTMDRLYFVM----EYVNG---GDLMYHIQQVGRFKEPHAV 444 V L G P +L + M E G G+L ++ R+ V Sbjct: 231 AVELLDGIPGWLVVFGVEYLRNGDFGRAMKRTLEVAKGLIMGELEELRRRSPRY-----V 285 Query: 445 FYAAEIAIG-------LFFLQSKGI---------IYRDLKLDNVMLDSEGHIKIAD 484 IA+G +L KG + +LK N +++ + KIAD Sbjct: 286 DILRAIALGYNRWSLIRDYLAVKGTKIPEPRLYALLENLKKMNWIVEEDNTYKIAD 341 >4BVU-A nrPDB Length = 211 Score = 34.2 bits (77), Expect = 0.20, Method: Composition-based stats. Identities = 22/136 (16%), Positives = 37/136 (27%), Gaps = 13/136 (9%) Query: 344 FLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFL 403 ++G+GS ++ + K ++ +E E + Sbjct: 44 LGKLIGQGSTAEIFEDVNDSSALY---KKYDLIGNQYNEILEMAWQESELFNAFYGDEAS 100 Query: 404 TQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGII 463 Q +Y M V G L + Y I L II Sbjct: 101 V----VIQYGGDVYLRMLRVPGTPLSDI--DTADIPDNIESLYLQLICK----LNELSII 150 Query: 464 YRDLKLDNVMLDSEGH 479 + DL N++ D E Sbjct: 151 HYDLNTGNMLYDKESE 166 >6FAI-l nrPDB Length = 425 Score = 33.8 bits (76), Expect = 0.22, Method: Composition-based stats. Identities = 31/248 (12%), Positives = 76/248 (30%), Gaps = 37/248 (14%) Query: 259 LSFGISELQKAGVDGWFKLLSQEEGEYFN--VPVP-------PEGSEGNEELRQKFERAK 309 + S ++ D + L + E+G + VP P G + Sbjct: 1 MKLDTSHMRYLTTDDFRVLQAVEQGSRSHEVVPTPLIHQISGMRSQSGTNRAISDLAKLS 60 Query: 310 IGQGTKAPEEKTAN-TISKFDNNGNRDRMKLTD-FNFLMVLGKGSFGKVMLSERKGTDEL 367 + + + T + D + + ++ +G G + K + Sbjct: 61 LISKMRNVKYDGYRLTYNGIDYLALKTMLNRDTVYSVGNTIGVGKESDIYKVSDKNGNPR 120 Query: 368 YAVKILKKDVV-----------IQDDDVECTMVEKRVLALPGKPPFLTQLH-------SC 409 +KI + ++ + + LA + F++ L+ Sbjct: 121 V-MKIHRLGRTSFHSVRNNRDYLKKSNQGANWMHLSRLAANKEYQFMSMLYSKGFKVPEP 179 Query: 410 FQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKL 469 F + VME + G + +++ +++ + L + G+I+ D Sbjct: 180 FDNSRHI-VVMELIEGYPMR-RLRKHKNIP-----KLYSDLMCFIVDLANSGLIHCDFNE 232 Query: 470 DNVMLDSE 477 N+M+ + Sbjct: 233 FNIMIKDK 240 >1R79-A nrPDB Length = 84 Score = 33.0 bits (74), Expect = 0.47, Method: Composition-based stats. Identities = 13/46 (28%), Positives = 17/46 (36%), Gaps = 4/46 (8%) Query: 48 TFCSH-CTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCPGADKG 92 T C C Q ++C C +VH C E + C G G Sbjct: 42 TVCDKTCGSV---LRLQDWRCLWCKAMVHTSCKESLLTKCSGPSSG 84 >3NPK-A nrPDB Length = 291 Score = 31.9 bits (71), Expect = 1.1, Method: Composition-based stats. Identities = 17/83 (20%), Positives = 31/83 (37%), Gaps = 6/83 (7%) Query: 387 TMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLM--YHIQQVGRFKEPHAV 444 + E + L P + H F L GG + V + +P + Sbjct: 4 NLKELFIHHLEKNLPKVESFHPFFNEALALMLK----AGGKHFRAQLLLSVVQSNKPELL 59 Query: 445 FYAAEIAIGLFFLQSKGIIYRDL 467 A ++A+ L F+ + +I+ DL Sbjct: 60 NQALDVALALEFIHTYSLIHDDL 82 >5DXT-A nrPDB Length = 962 Score = 31.5 bits (70), Expect = 1.2, Method: Composition-based stats. Identities = 17/87 (19%), Positives = 32/87 (36%), Gaps = 11/87 (12%) Query: 165 QAHIDREVLIVVVRDAK--NLVPMDPNGLSDPYVK--LKLIPDPKSESKQKTKTIKCSLN 220 + L + + A N+ D + + YV+ + +P ++ + N Sbjct: 220 SLWVINSALRIKILCATYVNVNIRDIDKI---YVRTGIYHGGEPLCDNVNTQRV--PCSN 274 Query: 221 PEWNETFRFQLKESDKDR--RLSVEIW 245 P WNE + + D R RL + I Sbjct: 275 PRWNEWLNYDIYIPDLPRAARLCLSIC 301 >5HVQ-C nrPDB Length = 238 Score = 31.1 bits (69), Expect = 1.6, Method: Composition-based stats. Identities = 13/33 (39%), Positives = 17/33 (51%), Gaps = 4/33 (12%) Query: 114 FCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMN 146 C+ C SLL QG C+TC + +H CV Sbjct: 182 ICNICHSLL----IQGQSCETCGIRMHLPCVAK 210 >2CT0-A nrPDB Length = 74 Score = 31.1 bits (69), Expect = 1.6, Method: Composition-based stats. Identities = 13/33 (39%), Positives = 17/33 (51%), Gaps = 4/33 (12%) Query: 114 FCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMN 146 C+ C SLL QG C+TC + +H CV Sbjct: 17 ICNICHSLL----IQGQSCETCGIRMHLPCVAK 45 >6EF6-A nrPDB Length = 354 Score = 30.3 bits (67), Expect = 2.6, Method: Composition-based stats. Identities = 11/28 (39%), Positives = 19/28 (67%), Gaps = 3/28 (10%) Query: 461 GIIYRDLKLDNVMLDS---EGHIKIADF 485 G+I+ DL+L N+++DS + I + DF Sbjct: 226 GLIHADLRLANLLVDSSTPQRTITVIDF 253 >5JEA-K nrPDB Length = 279 Score = 30.3 bits (67), Expect = 2.6, Method: Composition-based stats. Identities = 25/126 (19%), Positives = 44/126 (34%), Gaps = 10/126 (7%) Query: 224 NETFRFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLS---FGISELQKAGVDGWFKLLSQ 280 NE + + V I +++ S +D + S F ++ + +D +L Sbjct: 74 NELLGIFVPCNLPKTTRKVAIENFNRPSPDDIIQSAQLNAFNMNIFEMLRIDEGLRLKIY 133 Query: 281 EEGE-YFNVPV------PPEGSEGNEELRQKFERAKIGQGTKAPEEKTANTISKFDNNGN 333 ++ E Y+ + + P + EL + R G TK EK N G Sbjct: 134 KDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNTNGVITKDEAEKLFNQDVDAAVRGI 193 Query: 334 RDRMKL 339 KL Sbjct: 194 LRNAKL 199 >5G06-P nrPDB Length = 747 Score = 30.3 bits (67), Expect = 2.9, Method: Composition-based stats. Identities = 13/72 (18%), Positives = 26/72 (36%), Gaps = 1/72 (1%) Query: 224 NETFRFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKAGVDGWFKLLSQEEG 283 NE + + V I +++ S +D + S + ++ + E+ Sbjct: 184 NELLGIFVPCNLPKTTRKVAIENFNRPSPDDIIQSAQLNAFNEKLENLNI-KSVPKAEKK 242 Query: 284 EYFNVPVPPEGS 295 E N+ PP S Sbjct: 243 EPINLQTPPTES 254 >4N4M-A nrPDB Length = 500 Score = 29.9 bits (66), Expect = 3.2, Method: Composition-based stats. Identities = 16/66 (24%), Positives = 20/66 (30%), Gaps = 14/66 (21%) Query: 55 DFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKIHTYSSPTF 114 +F W GK + C CH C G ++HKF PT Sbjct: 172 EFSWHVGKPAEEVTGCA-----HCHAIAENRCSGC---------HTRHKFDPAEARKPTA 217 Query: 115 CDHCGS 120 C C Sbjct: 218 CRVCHM 223 >4GYG-A nrPDB Length = 397 Score = 29.9 bits (66), Expect = 3.3, Method: Composition-based stats. Identities = 14/78 (17%), Positives = 25/78 (32%), Gaps = 16/78 (20%) Query: 418 FVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSE 477 VM L+ + P A++ + L G+I+ D N+++ E Sbjct: 188 IVM------SLVDALPMRQVSSVPDPASLYADLIALILRLAKHGLIHGDFNEFNILIREE 241 Query: 478 GHIK----------IADF 485 + I DF Sbjct: 242 KDAEDPSSITLTPIIIDF 259 >1XOC-A nrPDB Length = 520 Score = 29.9 bits (66), Expect = 3.9, Method: Composition-based stats. Identities = 22/120 (18%), Positives = 42/120 (35%), Gaps = 13/120 (10%) Query: 234 SDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKAGVDGWFKLLSQEEGEYFNVPVPPE 293 D + V+ D + +D + + S +S+ K +++L E Sbjct: 82 YDVKIKKGVKFHDGKELTADDVVFTYSVPLSKDYKGERGSTYEMLKSVEK---------- 131 Query: 294 GSEGNEELRQKFERAKIGQGTKAPEEKTANTISKFDNNGNRDRMKLTDFNFLMVLGKGSF 353 +G+ E+ K + K G + TA N ++ +FN +G G F Sbjct: 132 --KGDYEVLFKLK-YKDGNFYNNALDSTAILPKHILGNVPIADLEENEFNRKKPIGSGPF 188 >6HIY-Cj nrPDB Length = 257 Score = 29.6 bits (65), Expect = 4.5, Method: Composition-based stats. Identities = 17/74 (22%), Positives = 28/74 (37%), Gaps = 7/74 (9%) Query: 233 ESDKDRRLSVEIWDWDLTSRN-------DFMGSLSFGISELQKAGVDGWFKLLSQEEGEY 285 E D+ +++ D+D F G + ++ A V GW+ +E Sbjct: 123 EGTYDKYVTLSAIDFDRDGNKGTAYGYITFHGETTTRPVQVDFADVPGWYMDFVEERAVP 182 Query: 286 FNVPVPPEGSEGNE 299 F VPP S G + Sbjct: 183 FTGIVPPPPSIGTD 196 >2ENQ-A nrPDB Length = 158 Score = 29.6 bits (65), Expect = 5.2, Method: Composition-based stats. Identities = 17/80 (21%), Positives = 31/80 (38%), Gaps = 11/80 (13%) Query: 172 VLIVVVRDAK--NLVPMDPNGLSDPYVK--LKLIPDPKSESKQKTKTIKCSLNPEWNETF 227 L + + A N+ D + + YV+ + +P ++ + NP WNE Sbjct: 10 ALRIKILCATYVNVNIRDIDKI---YVRTGIYHGGEPLCDNVNTQRV--PCSNPRWNEWL 64 Query: 228 RFQLKESDKDR--RLSVEIW 245 + + D R RL + I Sbjct: 65 NYDIYIPDLPRAARLCLSIC 84 >3CGL-A nrPDB Length = 243 Score = 29.2 bits (64), Expect = 6.3, Method: Composition-based stats. Identities = 21/95 (22%), Positives = 40/95 (42%), Gaps = 16/95 (16%) Query: 318 EEKTANTISKFDNNGNRDRMKLTDFNF-LMVLGKGSFG----KVMLSERKGTDELYAVKI 372 ++KT + RD + + D + L V G G + V +++ A+K+ Sbjct: 148 QKKTTGWEPSTERLYPRDGVLIGDIHHALTVEGGGHYACDIKTVYRAKKA------ALKM 201 Query: 373 -----LKKDVVIQDDDVECTMVEKRVLALPGKPPF 402 + +VI ++D E VE+ +A+ PF Sbjct: 202 PGYHYVDTKLVIWNNDKEFMKVEEHEIAVARHHPF 236 >3J9M-AD nrPDB Length = 430 Score = 28.8 bits (63), Expect = 8.8, Method: Composition-based stats. Identities = 11/52 (21%), Positives = 25/52 (48%) Query: 341 DFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKR 392 D N ++G+G +G + + AV+ + + + + VE M+++R Sbjct: 125 DLNRGQIIGEGRYGFLWPGLNVPLMKNGAVQTIAQRSKEEQEKVEADMIQQR 176 >5MMJ-n nrPDB Length = 100 Score = 28.8 bits (63), Expect = 9.1, Method: Composition-based stats. Identities = 13/89 (14%), Positives = 27/89 (30%), Gaps = 13/89 (14%) Query: 423 VNGGDLMYHIQQVGRFKEP--HAVFYAAEIAIGLFFLQSKGIIYRDLK--LDN------- 471 + L+ ++ ++ + + + L K I+ L+ N Sbjct: 1 MARKSLIQREKKRRNLEQKYHLIRRSSKQEIRKVTSLSDKWEIHGKLQSPPRNSAPARLH 60 Query: 472 --VMLDSEGHIKIADFGMCKENIWDGVTT 498 L I DFG+ + + V T Sbjct: 61 RRCFLTGRPRANIRDFGLSGHILREMVHT 89 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.311 0.143 0.435 Lambda K H 0.267 0.0440 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 29,579,499 Number of Sequences: 36641 Number of extensions: 1291870 Number of successful extensions: 7395 Number of sequences better than 10.0: 586 Number of HSP's better than 10.0 without gapping: 1014 Number of HSP's successfully gapped in prelim test: 99 Number of HSP's that attempted gapping in prelim test: 3243 Number of HSP's gapped (non-prelim): 1314 length of query: 671 length of database: 10,336,785 effective HSP length: 104 effective length of query: 567 effective length of database: 6,526,121 effective search space: 3700310607 effective search space used: 3700310607 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.2 bits) S2: 63 (28.8 bits)