BLASTP 2.2.23 [Feb-03-2010]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.


Reference for compositional score matrix adjustment: Altschul, Stephen F., 
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.


Reference for composition-based statistics starting in round 2:
Schaffer, Alejandro A., L. Aravind, Thomas L. Madden,
Sergei Shavirin, John L. Spouge, Yuri I. Wolf,  
Eugene V. Koonin, and Stephen F. Altschul (2001), 
"Improving the accuracy of PSI-BLAST protein database searches with 
composition-based statistics and other refinements",  Nucleic Acids Res. 29:2994-3005.

Query= P68400
         (391 letters)

Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 
           36,641 sequences; 10,336,785 total letters

Searching..................................................done


Results from round 1


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

4MD7-E nrPDB                                                          808   0.0  
6EII-A nrPDB                                                          683   0.0  
6HMD-A nrPDB                                                          563   e-161
2PVN-A nrPDB                                                          494   e-140
6O6Q-A nrPDB                                                          460   e-130
5XVU-A nrPDB                                                          422   e-118
4LFI-A nrPDB                                                          387   e-108
5Z33-A nrPDB                                                          160   8e-40
4E7W-A nrPDB                                                          158   4e-39
3OHT-A nrPDB                                                          143   2e-34
3NIZ-A nrPDB                                                          142   3e-34
4MYG-A nrPDB                                                          141   4e-34
3GC9-A nrPDB                                                          141   6e-34
1V0B-A nrPDB                                                          140   1e-33
2BPM-A nrPDB                                                          140   1e-33
1CM8-A nrPDB                                                          140   1e-33
5AIR-A nrPDB                                                          139   3e-33
6GU6-A nrPDB                                                          139   3e-33
4EWQ-A nrPDB                                                          137   6e-33
4KRC-A nrPDB                                                          136   2e-32
1UA2-A nrPDB                                                          135   3e-32
5NGU-A nrPDB                                                          133   2e-31
4QNY-A nrPDB                                                          132   2e-31
2F9G-A nrPDB                                                          131   4e-31
4AU8-A nrPDB                                                          131   4e-31
4QTB-A nrPDB                                                          131   4e-31
3EB0-A nrPDB                                                          131   5e-31
3OZ6-A nrPDB                                                          130   7e-31
6DTL-A nrPDB                                                          130   1e-30
1G3N-A nrPDB                                                          128   5e-30
4AGU-A nrPDB                                                          126   1e-29
3GC0-A nrPDB                                                          124   6e-29
4IC8-A nrPDB                                                          124   7e-29
5G6V-A nrPDB                                                          123   2e-28
5EFQ-A nrPDB                                                          122   2e-28
4ZSG-A nrPDB                                                          121   5e-28
3E3P-A nrPDB                                                          118   5e-27
4NST-A nrPDB                                                          117   9e-27
3PG1-A nrPDB                                                          117   9e-27
4BBM-A nrPDB                                                          117   1e-26
4BGQ-A nrPDB                                                          116   2e-26
2I6L-A nrPDB                                                          114   9e-26
3MIA-A nrPDB                                                          114   1e-25
3NIE-A nrPDB                                                          110   2e-24
3RP9-A nrPDB                                                          109   2e-24
5Y86-A nrPDB                                                          108   5e-24
4O2Z-A nrPDB                                                          107   1e-23
2W96-B nrPDB                                                          105   2e-23
3ZDU-A nrPDB                                                          104   7e-23
5ZTN-A nrPDB                                                          103   1e-22
3MN3-A nrPDB                                                          103   2e-22
3E7O-A nrPDB                                                          102   3e-22
2X4F-A nrPDB                                                          101   6e-22
5JN2-A nrPDB                                                          100   1e-21
3N9X-A nrPDB                                                          100   2e-21
1JNK-A nrPDB                                                           99   3e-21
3MA6-A nrPDB                                                           99   4e-21
4NIF-A nrPDB                                                           98   5e-21
4CRL-A nrPDB                                                           98   6e-21
3FI2-A nrPDB                                                           97   8e-21
2XS0-A nrPDB                                                           97   8e-21
5AWM-A nrPDB                                                           97   1e-20
2J90-A nrPDB                                                           97   2e-20
3LIJ-A nrPDB                                                           96   3e-20
3NCG-A nrPDB                                                           95   4e-20
3DFA-A nrPDB                                                           95   5e-20
1KOB-A nrPDB                                                           95   6e-20
3DXN-A nrPDB                                                           94   7e-20
4MVF-A nrPDB                                                           94   1e-19
4F9B-A nrPDB                                                           93   2e-19
4YNZ-A nrPDB                                                           93   2e-19
3HZT-A nrPDB                                                           93   2e-19
6FDY-U nrPDB                                                           92   3e-19
5ES1-A nrPDB                                                           92   4e-19
4JG6-A nrPDB                                                           92   6e-19
2Y7J-A nrPDB                                                           91   7e-19
3KN6-A nrPDB                                                           91   8e-19
3TAC-A nrPDB                                                           91   9e-19
2YAB-A nrPDB                                                           91   1e-18
2VN9-A nrPDB                                                           89   3e-18
1ZWS-A nrPDB                                                           89   3e-18
5YKS-A nrPDB                                                           89   3e-18
4C0T-A nrPDB                                                           89   4e-18
6QAU-A nrPDB                                                           88   5e-18
5XZW-A nrPDB                                                           88   6e-18
2HW6-A nrPDB                                                           88   7e-18
3D2K-A nrPDB                                                           88   7e-18
2VZ6-A nrPDB                                                           87   8e-18
3F3Z-A nrPDB                                                           87   9e-18
1TKI-A nrPDB                                                           87   1e-17
5U6Y-A nrPDB                                                           87   1e-17
2A27-A nrPDB                                                           87   1e-17
2QNJ-A nrPDB                                                           87   2e-17
4UZD-A nrPDB                                                           87   2e-17
5UNP-A nrPDB                                                           87   2e-17
2HAK-A nrPDB                                                           86   2e-17
3Q5I-A nrPDB                                                           86   2e-17
6CMJ-A nrPDB                                                           86   2e-17
4FG9-A nrPDB                                                           86   2e-17
3GUB-A nrPDB                                                           86   2e-17
4CFF-A nrPDB                                                           86   3e-17
4PDS-A nrPDB                                                           86   3e-17
3ORZ-A nrPDB                                                           86   3e-17
2WO6-A nrPDB                                                           86   3e-17
3UTO-A nrPDB                                                           86   3e-17
5EZV-A nrPDB                                                           86   3e-17
5WAX-A nrPDB                                                           86   4e-17
6C9D-A nrPDB                                                           86   4e-17
1KOA-A nrPDB                                                           85   4e-17
5KZ7-A nrPDB                                                           85   7e-17
4YZB-A nrPDB                                                           84   8e-17
5FG8-A nrPDB                                                           84   8e-17
4CZT-A nrPDB                                                           84   9e-17
3SOA-A nrPDB                                                           84   1e-16
4RLP-A nrPDB                                                           84   1e-16
3BHH-A nrPDB                                                           84   1e-16
4L42-A nrPDB                                                           84   1e-16
2BDW-A nrPDB                                                           83   2e-16
2JC6-A nrPDB                                                           83   2e-16
4RGJ-A nrPDB                                                           83   2e-16
2YZA-A nrPDB                                                           83   3e-16
4D2V-A nrPDB                                                           82   3e-16
3RAW-A nrPDB                                                           82   3e-16
3KK8-A nrPDB                                                           82   4e-16
5X8I-B nrPDB                                                           82   5e-16
4WNO-A nrPDB                                                           82   5e-16
2W4O-A nrPDB                                                           82   5e-16
3H4J-B nrPDB                                                           82   5e-16
1PHK-A nrPDB                                                           81   9e-16
5IG1-A nrPDB                                                           80   1e-15
4I6B-A nrPDB                                                           80   1e-15
5TUR-A nrPDB                                                           80   1e-15
4REW-A nrPDB                                                           80   1e-15
3A8W-A nrPDB                                                           80   1e-15
5UUU-A nrPDB                                                           80   2e-15
2WQN-A nrPDB                                                           80   2e-15
1NY3-A nrPDB                                                           79   3e-15
4CQG-A nrPDB                                                           79   3e-15
2OZA-A nrPDB                                                           79   3e-15
4B6L-A nrPDB                                                           79   3e-15
3BGP-A nrPDB                                                           79   3e-15
3PVW-A nrPDB                                                           79   3e-15
4RC3-A nrPDB                                                           79   4e-15
2V7O-A nrPDB                                                           79   4e-15
4CFH-A nrPDB                                                           79   4e-15
3KA0-A nrPDB                                                           79   4e-15
5YV8-A nrPDB                                                           79   4e-15
5D9K-A nrPDB                                                           79   4e-15
2YCR-A nrPDB                                                           79   5e-15
4JXF-A nrPDB                                                           79   5e-15
4D28-A nrPDB                                                           78   5e-15
2Z7Q-A nrPDB                                                           78   5e-15
5JZN-A nrPDB                                                           78   6e-15
6FD3-A nrPDB                                                           78   7e-15
6FYV-A nrPDB                                                           77   1e-14
3UC3-A nrPDB                                                           77   1e-14
2BRG-A nrPDB                                                           77   1e-14
4RED-A nrPDB                                                           77   1e-14
3I6U-A nrPDB                                                           76   3e-14
2JD5-A nrPDB                                                           76   3e-14
1U5R-A nrPDB                                                           76   3e-14
5J5T-A nrPDB                                                           75   3e-14
4X7Q-B nrPDB                                                           75   4e-14
3FXW-A nrPDB                                                           75   4e-14
3ZUT-A nrPDB                                                           75   5e-14
2GCD-A nrPDB                                                           75   6e-14
3LM0-A nrPDB                                                           75   7e-14
3HKO-A nrPDB                                                           74   7e-14
2JAM-A nrPDB                                                           74   8e-14
6CKI-A nrPDB                                                           74   9e-14
3NYO-A nrPDB                                                           74   9e-14
1VZO-A nrPDB                                                           74   1e-13
3LLT-A nrPDB                                                           74   1e-13
6ED6-A nrPDB                                                           74   2e-13
3TXO-A nrPDB                                                           73   2e-13
3HDN-A nrPDB                                                           73   2e-13
3DB8-A nrPDB                                                           73   2e-13
4B8L-A nrPDB                                                           73   2e-13
5D7A-A nrPDB                                                           73   3e-13
3DLS-A nrPDB                                                           72   3e-13
3UDB-A nrPDB                                                           72   4e-13
5F9E-A nrPDB                                                           72   4e-13
4FIE-A nrPDB                                                           72   5e-13
3Q53-A nrPDB                                                           72   5e-13
6E9W-A nrPDB                                                           72   6e-13
3ORP-A nrPDB                                                           71   7e-13
3QA8-A nrPDB                                                           71   7e-13
4TNB-A nrPDB                                                           71   9e-13
4JDH-A nrPDB                                                           70   1e-12
6HXF-B nrPDB                                                           70   1e-12
1FOT-A nrPDB                                                           70   1e-12
4AF3-A nrPDB                                                           70   1e-12
4KIK-B nrPDB                                                           70   2e-12
2Q0N-A nrPDB                                                           70   2e-12
6DBM-A nrPDB                                                           70   2e-12
2OU7-A nrPDB                                                           70   2e-12
2JDO-A nrPDB                                                           70   2e-12
4QMW-A nrPDB                                                           69   2e-12
6CQF-A nrPDB                                                           69   3e-12
4KS7-A nrPDB                                                           69   3e-12
4J52-A nrPDB                                                           69   3e-12
4OLI-A nrPDB                                                           69   4e-12
6BDL-A nrPDB                                                           69   5e-12
4XBR-A nrPDB                                                           69   5e-12
4EQM-A nrPDB                                                           68   6e-12
2XNP-A nrPDB                                                           68   6e-12
3DAK-A nrPDB                                                           67   1e-11
1ZXE-A nrPDB                                                           67   1e-11
3M42-A nrPDB                                                           67   1e-11
4NFN-A nrPDB                                                           67   1e-11
4BTK-A nrPDB                                                           67   1e-11
4WUA-A nrPDB                                                           67   2e-11
3IS5-A nrPDB                                                           66   2e-11
3PFQ-A nrPDB                                                           66   3e-11
4U41-A nrPDB                                                           66   3e-11
2I0E-A nrPDB                                                           66   3e-11
5KCV-A nrPDB                                                           65   4e-11
2UV2-A nrPDB                                                           65   5e-11
5FET-A nrPDB                                                           65   5e-11
3C51-A nrPDB                                                           65   6e-11
5DYK-A nrPDB                                                           65   6e-11
3MV5-A nrPDB                                                           65   6e-11
3COM-A nrPDB                                                           65   7e-11
6CCF-A nrPDB                                                           64   8e-11
6DBN-A nrPDB                                                           64   9e-11
5N23-A nrPDB                                                           64   9e-11
4RA4-A nrPDB                                                           64   1e-10
4AW2-A nrPDB                                                           64   1e-10
4IAN-A nrPDB                                                           64   1e-10
6E2O-A nrPDB                                                           64   1e-10
4WB7-A nrPDB                                                           64   1e-10
5FQD-C nrPDB                                                           64   1e-10
4X3F-A nrPDB                                                           64   1e-10
5TQX-A nrPDB                                                           63   2e-10
5X3F-B nrPDB                                                           63   2e-10
2WTK-C nrPDB                                                           63   2e-10
4OW8-A nrPDB                                                           63   3e-10
2XIK-A nrPDB                                                           63   3e-10
6B2Q-A nrPDB                                                           62   3e-10
4E20-A nrPDB                                                           62   3e-10
2PMN-X nrPDB                                                           62   3e-10
4C59-A nrPDB                                                           62   4e-10
3VN9-A nrPDB                                                           62   4e-10
2X7G-A nrPDB                                                           62   4e-10
3OMV-A nrPDB                                                           62   5e-10
5DBX-A nrPDB                                                           62   5e-10
4LG4-A nrPDB                                                           62   5e-10
2F57-A nrPDB                                                           62   5e-10
5LOH-A nrPDB                                                           62   5e-10
4YHJ-A nrPDB                                                           61   7e-10
3TKU-A nrPDB                                                           61   9e-10
4FR4-A nrPDB                                                           61   9e-10
6AO5-A nrPDB                                                           60   1e-09
4FZF-B nrPDB                                                           60   1e-09
2DQ7-X nrPDB                                                           60   1e-09
3FME-A nrPDB                                                           59   3e-09
4E93-A nrPDB                                                           59   3e-09
3ALO-A nrPDB                                                           59   3e-09
4M66-A nrPDB                                                           59   3e-09
6HV0-A nrPDB                                                           59   4e-09
4PL5-B nrPDB                                                           59   5e-09
4CSV-A nrPDB                                                           59   5e-09
2PZI-A nrPDB                                                           58   6e-09
4HVI-A nrPDB                                                           58   6e-09
4Y12-A nrPDB                                                           58   7e-09
6GVJ-A nrPDB                                                           58   8e-09
5HI2-A nrPDB                                                           58   9e-09
5H2U-A nrPDB                                                           57   1e-08
4APC-A nrPDB                                                           57   1e-08
5O2B-A nrPDB                                                           57   1e-08
4IDT-A nrPDB                                                           57   1e-08
5O2C-A nrPDB                                                           57   1e-08
4H1J-A nrPDB                                                           57   2e-08
2VD5-A nrPDB                                                           56   2e-08
3HMP-A nrPDB                                                           56   2e-08
2ZMD-A nrPDB                                                           56   2e-08
3SV0-A nrPDB                                                           56   2e-08
5X5O-A nrPDB                                                           56   3e-08
4PWN-A nrPDB                                                           56   3e-08
4XEY-B nrPDB                                                           56   3e-08
5HIE-A nrPDB                                                           56   3e-08
6BXI-A nrPDB                                                           55   4e-08
5AP3-A nrPDB                                                           55   4e-08
2H8H-A nrPDB                                                           55   4e-08
6F3F-A nrPDB                                                           55   4e-08
4G3E-A nrPDB                                                           55   7e-08
2W1I-A nrPDB                                                           55   7e-08
3IO7-A nrPDB                                                           55   7e-08
3CJF-A nrPDB                                                           55   7e-08
2FO0-A nrPDB                                                           54   8e-08
4LQP-A nrPDB                                                           54   8e-08
2BUJ-A nrPDB                                                           54   9e-08
3BEA-A nrPDB                                                           54   1e-07
6NPU-A nrPDB                                                           54   1e-07
5O0Y-A nrPDB                                                           54   1e-07
5KKR-C nrPDB                                                           54   1e-07
3EQC-A nrPDB                                                           53   2e-07
4AN9-A nrPDB                                                           53   2e-07
6CTH-A nrPDB                                                           53   2e-07
4M7I-A nrPDB                                                           53   2e-07
5VD3-A nrPDB                                                           53   2e-07
3A4O-X nrPDB                                                           52   3e-07
3PLS-A nrPDB                                                           52   4e-07
3PP0-A nrPDB                                                           52   5e-07
2CMW-A nrPDB                                                           52   5e-07
5HLW-A nrPDB                                                           52   5e-07
5X02-A nrPDB                                                           52   6e-07
2PL0-A nrPDB                                                           52   6e-07
5TE0-A nrPDB                                                           51   7e-07
5HVK-A nrPDB                                                           51   7e-07
2C47-A nrPDB                                                           51   8e-07
5A46-A nrPDB                                                           51   8e-07
4XUF-A nrPDB                                                           51   9e-07
3TT0-A nrPDB                                                           51   1e-06
3GQL-A nrPDB                                                           50   1e-06
5SYS-A nrPDB                                                           50   1e-06
2XYN-A nrPDB                                                           50   2e-06
4EBW-A nrPDB                                                           50   2e-06
3KRL-A nrPDB                                                           50   2e-06
5GRN-A nrPDB                                                           50   2e-06
2A1A-B nrPDB                                                           50   2e-06
2OGV-A nrPDB                                                           50   2e-06
4TN6-A nrPDB                                                           49   3e-06
6GQK-A nrPDB                                                           49   4e-06
3MY0-A nrPDB                                                           49   4e-06
5IKW-A nrPDB                                                           49   4e-06
1S9I-A nrPDB                                                           49   4e-06
3UIU-A nrPDB                                                           49   4e-06
2CHL-A nrPDB                                                           49   5e-06
2HK5-A nrPDB                                                           49   5e-06
4TPT-A nrPDB                                                           48   6e-06
3DTC-A nrPDB                                                           48   6e-06
3PPZ-A nrPDB                                                           48   7e-06
4UYA-A nrPDB                                                           48   7e-06
2J0K-A nrPDB                                                           48   8e-06
5B2L-A nrPDB                                                           48   8e-06
4UY9-A nrPDB                                                           47   1e-05
4K33-A nrPDB                                                           47   1e-05
4EUU-A nrPDB                                                           47   1e-05
3C1X-A nrPDB                                                           47   1e-05
3G0E-A nrPDB                                                           47   1e-05
4EUT-A nrPDB                                                           47   2e-05
4OTD-A nrPDB                                                           47   2e-05
5M07-A nrPDB                                                           47   2e-05
5AMN-A nrPDB                                                           46   2e-05
4GS6-A nrPDB                                                           46   2e-05
4R7H-A nrPDB                                                           46   2e-05
4JLC-A nrPDB                                                           46   2e-05
5FM2-A nrPDB                                                           46   2e-05
1AD5-A nrPDB                                                           46   4e-05
6NT9-A nrPDB                                                           45   4e-05
2H34-A nrPDB                                                           45   4e-05
4RT7-A nrPDB                                                           45   4e-05
3MDY-A nrPDB                                                           45   5e-05
1CSN-A nrPDB                                                           45   5e-05
4NT4-A nrPDB                                                           45   5e-05
5CEK-A nrPDB                                                           45   5e-05
6O8B-A nrPDB                                                           45   5e-05
2RIO-A nrPDB                                                           45   6e-05
2PSQ-A nrPDB                                                           45   6e-05
4NEU-A nrPDB                                                           45   7e-05
5WNL-A nrPDB                                                           45   8e-05
5EG3-A nrPDB                                                           45   8e-05
5L2Q-C nrPDB                                                           44   8e-05
4P5Q-A nrPDB                                                           44   8e-05
4AT3-A nrPDB                                                           44   1e-04
6DC0-A nrPDB                                                           44   1e-04
2VWV-A nrPDB                                                           44   1e-04
5AR8-A nrPDB                                                           44   1e-04
3QUP-A nrPDB                                                           44   1e-04
4CRS-A nrPDB                                                           44   2e-04
5U6B-A nrPDB                                                           44   2e-04
2WTK-B nrPDB                                                           44   2e-04
4LRM-A nrPDB                                                           44   2e-04
4Y83-A nrPDB                                                           43   2e-04
3KUL-B nrPDB                                                           43   2e-04
4XLV-A nrPDB                                                           43   2e-04
4XCU-A nrPDB                                                           43   2e-04
3HNG-A nrPDB                                                           43   3e-04
2R2P-A nrPDB                                                           42   4e-04
5X18-A nrPDB                                                           42   4e-04
1FVR-A nrPDB                                                           42   5e-04
3VHK-A nrPDB                                                           42   6e-04
3QD2-B nrPDB                                                           42   6e-04
4XHH-A nrPDB                                                           41   7e-04
3BBT-B nrPDB                                                           41   8e-04
2QLU-A nrPDB                                                           41   8e-04
3ZZW-A nrPDB                                                           41   0.001
4XHL-A nrPDB                                                           41   0.001
3LZB-A nrPDB                                                           40   0.001
4IX6-A nrPDB                                                           40   0.001
5GNK-A nrPDB                                                           40   0.001
4CI6-B nrPDB                                                           40   0.002
3DKO-A nrPDB                                                           40   0.002
1JPA-A nrPDB                                                           39   0.003
4JRN-A nrPDB                                                           39   0.003
4YFF-A nrPDB                                                           39   0.003
5DMZ-A nrPDB                                                           39   0.003
3V5Q-A nrPDB                                                           39   0.003
5VO2-A nrPDB                                                           39   0.003
4XI2-A nrPDB                                                           39   0.004
6E4F-A nrPDB                                                           39   0.004
5MJB-A nrPDB                                                           39   0.004
3SOC-A nrPDB                                                           39   0.005
1LUF-A nrPDB                                                           39   0.006
4Y93-A nrPDB                                                           37   0.011
5U6C-A nrPDB                                                           37   0.014
5L6P-A nrPDB                                                           37   0.017
2Y6O-A nrPDB                                                           37   0.017
2QKW-B nrPDB                                                           37   0.017
2OZO-A nrPDB                                                           37   0.017
5WNO-A nrPDB                                                           37   0.017
1U59-A nrPDB                                                           37   0.017
2Y4I-B nrPDB                                                           37   0.019
5CLR-A nrPDB                                                           36   0.024
1BYG-A nrPDB                                                           36   0.024
1K9A-A nrPDB                                                           36   0.028
4PDO-A nrPDB                                                           36   0.029
3G2F-A nrPDB                                                           35   0.051
3BIQ-A nrPDB                                                           35   0.054
3ZBF-A nrPDB                                                           34   0.089
4FL3-A nrPDB                                                           34   0.097
5TOS-A nrPDB                                                           34   0.12 
4AZV-A nrPDB                                                           33   0.15 
3UIM-A nrPDB                                                           33   0.16 
5C26-A nrPDB                                                           33   0.18 
4AZW-A nrPDB                                                           33   0.18 
2RSV-A nrPDB                                                           33   0.22 
4O1O-A nrPDB                                                           33   0.24 
5VC6-A nrPDB                                                           33   0.25 
6G4J-A nrPDB                                                           33   0.25 
2LAV-A nrPDB                                                           33   0.26 
5XD6-A nrPDB                                                           32   0.33 
6BFN-A nrPDB                                                           32   0.54 
3SXS-A nrPDB                                                           32   0.61 
5UIU-A nrPDB                                                           31   1.1  
3LMG-A nrPDB                                                           30   1.2  
5LPZ-A nrPDB                                                           30   1.4  
3JB4-B nrPDB                                                           30   1.4  
6J6I-B nrPDB                                                           30   1.6  
5VDK-A nrPDB                                                           30   1.6  
5LPV-A nrPDB                                                           30   1.8  
1JKF-A nrPDB                                                           30   2.5  
4V1O-Q nrPDB                                                           29   3.2  
4OAU-C nrPDB                                                           29   4.0  
5UU1-A nrPDB                                                           28   5.0  
3LY6-A nrPDB                                                           28   5.3  
4W6Q-A nrPDB                                                           28   5.4  
5OAT-A nrPDB                                                           28   5.6  

>4MD7-E nrPDB
          Length = 391

 Score =  808 bits (2086), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 387/391 (98%), Positives = 387/391 (98%)

Query: 1   MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINIT 60
           MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINIT
Sbjct: 1   MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINIT 60

Query: 61  NNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTD 120
           NNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTD
Sbjct: 61  NNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTD 120

Query: 121 FKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE 180
           FKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE
Sbjct: 121 FKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE 180

Query: 181 FYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYD 240
           FYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYD
Sbjct: 181 FYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYD 240

Query: 241 QLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDF 300
           QLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDF
Sbjct: 241 QLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDF 300

Query: 301 LDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPT 360
           LDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGS PVSSANMMSGISSVP 
Sbjct: 301 LDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSEPVSSANMMSGISSVPE 360

Query: 361 PSPLGPLAGSPVIAAANPLGMPVPAAAGAQQ 391
           P PLGPLAG PVIAAANPLGMPVPAAAGAQQ
Sbjct: 361 PEPLGPLAGEPVIAAANPLGMPVPAAAGAQQ 391


>6EII-A nrPDB
          Length = 352

 Score =  683 bits (1763), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 327/328 (99%), Positives = 327/328 (99%)

Query: 2   SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITN 61
           SGPVPSRARVYTDVNTHRP EYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITN
Sbjct: 25  SGPVPSRARVYTDVNTHRPSEYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITN 84

Query: 62  NEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDF 121
           NEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDF
Sbjct: 85  NEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDF 144

Query: 122 KQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF 181
           KQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF
Sbjct: 145 KQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF 204

Query: 182 YHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQ 241
           YHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQ
Sbjct: 205 YHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQ 264

Query: 242 LVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFL 301
           LVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFL
Sbjct: 265 LVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFL 324

Query: 302 DKLLRYDHQSRLTAREAMEHPYFYTVVK 329
           DKLLRYDHQSRLTAREAMEHPYFYTVVK
Sbjct: 325 DKLLRYDHQSRLTAREAMEHPYFYTVVK 352


>6HMD-A nrPDB
          Length = 365

 Score =  563 bits (1452), Expect = e-161,   Method: Compositional matrix adjust.
 Identities = 289/355 (81%), Positives = 314/355 (88%), Gaps = 7/355 (1%)

Query: 1   MSGPVP-SRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINI 59
           M GP   SRARVY +VN+ R REYWDYE+HV  WGNQDDYQLVRKLGRGKYSEVFEAINI
Sbjct: 16  MPGPAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINI 75

Query: 60  TNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNT 119
           TNNE+VVVKILKPVKKKKIKRE+KILENLRGG NII L D VKDPVS+TPALVFE++NNT
Sbjct: 76  TNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNT 135

Query: 120 DFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA 179
           DFKQLYQ LTD+DIRFYMYE+LKALDYCHS GIMHRDVKPHNVMIDH+ +KLRLIDWGLA
Sbjct: 136 DFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLA 195

Query: 180 EFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNY 239
           EFYHP QEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFR+EPFFHG DNY
Sbjct: 196 EFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNY 255

Query: 240 DQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALD 299
           DQLVRIAKVLGTE+LY Y+ KY+I+LDP FNDILG+HSRKRWE F+HSEN+HLVSPEALD
Sbjct: 256 DQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALD 315

Query: 300 FLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSG 354
            LDKLLRYDHQ RLTA+EAMEHPYFY VVK+Q      S P     V S+ + + 
Sbjct: 316 LLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQ------SQPSADNAVLSSGLTAA 364


>2PVN-A nrPDB
          Length = 352

 Score =  494 bits (1272), Expect = e-140,   Method: Compositional matrix adjust.
 Identities = 250/325 (76%), Positives = 286/325 (88%)

Query: 3   GPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNN 62
           G   S+ARVY DVN  RP+EYWDYE+  V+WG QDDY++VRK+GRGKYSEVFE IN+ NN
Sbjct: 18  GSHMSKARVYADVNVLRPKEYWDYEALTVQWGEQDDYEVVRKVGRGKYSEVFEGINVNNN 77

Query: 63  EKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFK 122
           EK ++KILKPVKKKKIKREIKIL+NL GGPNI+ L DIV+D  S+TP+L+FE+VNNTDFK
Sbjct: 78  EKCIIKILKPVKKKKIKREIKILQNLCGGPNIVKLLDIVRDQHSKTPSLIFEYVNNTDFK 137

Query: 123 QLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFY 182
            LY TLTDYDIR+Y+YE+LKALDYCHS GIMHRDVKPHNVMIDHE RKLRLIDWGLAEFY
Sbjct: 138 VLYPTLTDYDIRYYIYELLKALDYCHSQGIMHRDVKPHNVMIDHELRKLRLIDWGLAEFY 197

Query: 183 HPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQL 242
           HPG+EYNVRVASRYFKGPELLVD Q YDYSLDMWSLGCM A MIFRKEPFF+GHDN+DQL
Sbjct: 198 HPGKEYNVRVASRYFKGPELLVDLQDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQL 257

Query: 243 VRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLD 302
           V+IAKVLGT+ L  Y++KY IELDP+   ++GRHSRK W +F++++NQHLVSPEA+DFLD
Sbjct: 258 VKIAKVLGTDGLNAYLNKYRIELDPQLEALVGRHSRKPWLKFMNADNQHLVSPEAIDFLD 317

Query: 303 KLLRYDHQSRLTAREAMEHPYFYTV 327
           KLLRYDHQ RLTA EAM HPYF  V
Sbjct: 318 KLLRYDHQERLTALEAMTHPYFQQV 342


>6O6Q-A nrPDB
          Length = 335

 Score =  460 bits (1183), Expect = e-130,   Method: Compositional matrix adjust.
 Identities = 211/320 (65%), Positives = 264/320 (82%), Gaps = 1/320 (0%)

Query: 5   VPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEK 64
           V S +RVY DV + +P+ YWDY+   ++W  Q++Y+++RKLGRGKYSEVF  I++   EK
Sbjct: 9   VQSVSRVYADVLSTKPQSYWDYDDLNIKWNPQENYEILRKLGRGKYSEVFLGIDLEKREK 68

Query: 65  VVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQL 124
           VV+K+LKPVK+KKIKREI IL+NL  GPNII + D+V++P S+TP L+FEH+NN DF+ L
Sbjct: 69  VVIKVLKPVKRKKIKREISILKNLVDGPNIIAMLDVVREPQSKTPGLIFEHINNIDFRSL 128

Query: 125 YQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHP 184
           Y T TDYDIRFYMYE+LKALDY HSMGIMHRDVKPHNVMIDH+ + LRLIDWGLAE+YHP
Sbjct: 129 YPTFTDYDIRFYMYELLKALDYSHSMGIMHRDVKPHNVMIDHDKKLLRLIDWGLAEYYHP 188

Query: 185 GQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVR 244
           G EYNVRVASRYFKGPELLVDY++YDYSLDMWS GCMLASM+F KEPFFHG  N DQLV+
Sbjct: 189 GTEYNVRVASRYFKGPELLVDYRLYDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQLVQ 248

Query: 245 IAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKL 304
           I +VLG+++   Y++KYNI L   + DI G +++++W RF++  N+ LVS E LD +D+L
Sbjct: 249 IVRVLGSKNFKKYLEKYNISLGEEYEDI-GYYNKRQWVRFMNENNKDLVSQEFLDLIDRL 307

Query: 305 LRYDHQSRLTAREAMEHPYF 324
           LRYDHQ RLTA+EAM+H YF
Sbjct: 308 LRYDHQERLTAKEAMKHAYF 327


>5XVU-A nrPDB
          Length = 332

 Score =  422 bits (1085), Expect = e-118,   Method: Compositional matrix adjust.
 Identities = 209/323 (64%), Positives = 261/323 (80%)

Query: 10  RVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKI 69
           + Y DVN H+P+EY+DY++  ++W   + Y++++K+GRGKYSEVF   +   N    +K+
Sbjct: 4   KFYADVNIHKPKEYYDYDNLELQWNKPNRYEIMKKIGRGKYSEVFNGYDTECNRPCAIKV 63

Query: 70  LKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLT 129
           LKPVKKKKIKREIKIL+NL GGPNII L DIVKDPV++TP+L+FE++NN DFK LY   T
Sbjct: 64  LKPVKKKKIKREIKILQNLNGGPNIIKLLDIVKDPVTKTPSLIFEYINNIDFKTLYPKFT 123

Query: 130 DYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYN 189
           D DIR+Y+Y+ILKALDYCHS GIMHRDVKPHN+MIDHE+R++RLI WGLAEFYHPGQEYN
Sbjct: 124 DKDIRYYIYQILKALDYCHSQGIMHRDVKPHNIMIDHENRQIRLISWGLAEFYHPGQEYN 183

Query: 190 VRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVL 249
           VRVASRY+KGPELL+D Q+YDYSLD+WSLGCMLA MIF+KEPFF GHDNYDQLV+IAKVL
Sbjct: 184 VRVASRYYKGPELLIDLQLYDYSLDIWSLGCMLAGMIFKKEPFFCGHDNYDQLVKIAKVL 243

Query: 250 GTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDH 309
           GTEDL+ Y+ KYNI+L P + +ILG + RK W  F+   N  +   E +D +DK+L YDH
Sbjct: 244 GTEDLHAYLKKYNIKLKPHYLNILGEYERKPWSHFLTQSNIDIAKDEVIDLIDKMLIYDH 303

Query: 310 QSRLTAREAMEHPYFYTVVKDQA 332
             R+  +EAMEHPYF  V ++ A
Sbjct: 304 AKRIAPKEAMEHPYFREVREESA 326


>4LFI-A nrPDB
          Length = 374

 Score =  387 bits (994), Expect = e-108,   Method: Compositional matrix adjust.
 Identities = 200/364 (54%), Positives = 253/364 (69%), Gaps = 41/364 (11%)

Query: 1   MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWG-NQDDYQLVRKLGRGKYSEVFEAINI 59
           M   V S ARVYT++N  R  EYWDYE+ V++W  N  DY++  K+GRGKYSEVF+ + +
Sbjct: 3   MKCRVWSEARVYTNINKQRTEEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKL 62

Query: 60  TNNEKVVVKI---------------LKPVKKKKI--------------KREIKILENLR- 89
            +  K+V+K+               L  +  +K+               ++  +L+ +R 
Sbjct: 63  DSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRP 122

Query: 90  --------GGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEIL 141
                   G  NII L DI+KDP+S+TPALVFE+V+N DF+ LY  LTD +IRFYM+E+L
Sbjct: 123 YIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPKLTDLEIRFYMFELL 182

Query: 142 KALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPE 201
           KALDYCHSMGIMHRDVKPHNVMIDH+++KLRLIDWGLAEFYH   EYNVRVASR+FKGPE
Sbjct: 183 KALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPE 242

Query: 202 LLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKY 261
           LLVDY+MYDYSLD+WS G MLASMIF++EPFFHG  N DQLV+I KVLGT D   Y+ KY
Sbjct: 243 LLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKY 302

Query: 262 NIELDPRFNDILGRHSRKRWERFVHSENQHLV-SPEALDFLDKLLRYDHQSRLTAREAME 320
            I L   F D + ++ RK W RF++  N+HL  + E +D +D LLRYDHQ RLTA+EAM 
Sbjct: 303 EITLPREFYD-MDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMG 361

Query: 321 HPYF 324
           HP+F
Sbjct: 362 HPWF 365


>5Z33-A nrPDB
          Length = 425

 Score =  160 bits (405), Expect = 8e-40,   Method: Compositional matrix adjust.
 Identities = 97/301 (32%), Positives = 168/301 (55%), Gaps = 22/301 (7%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIK-----REIKILENLRGGPN 93
           Y + ++LG+G Y  V  A+N   +E V +K +  V  KKI      REIK+L++ RG  N
Sbjct: 33  YTVTKELGQGAYGIVCAAVNNQTSEGVAIKKVTNVFSKKILAKRALREIKLLQHFRGHRN 92

Query: 94  IITLADI-VKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCHS 149
           I  L D+ +  P +     ++E +   D   +    Q LTD   + ++Y+IL  L Y HS
Sbjct: 93  ITCLYDMDIPRPDNFNETYLYEELMECDLAAIIRSGQPLTDAHFQSFIYQILCGLKYIHS 152

Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVR-----VASRYFKGPELLV 204
             ++HRD+KP N++++ +  +L++ D+GLA  +    E N       VA+R+++ PE+++
Sbjct: 153 ANVLHRDLKPGNLLVNADC-ELKICDFGLARGFSVDPEENAGYMTEYVATRWYRAPEIML 211

Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIE 264
            +Q Y  ++D+WS+GC+LA ++  + PFF G D  DQL +I  +LGT +  + + +    
Sbjct: 212 SFQSYTKAIDVWSVGCILAELLGGR-PFFKGRDYVDQLNQILHILGTPN-EETLSRIGSP 269

Query: 265 LDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324
               +   L   ++K +     + N     P+ALD LD++L +D  SR++  +A+EHPY 
Sbjct: 270 RAQEYVRNLPFMAKKPFPTLFPNAN-----PDALDLLDRMLAFDPSSRISVEQALEHPYL 324

Query: 325 Y 325
           +
Sbjct: 325 H 325


>4E7W-A nrPDB
          Length = 394

 Score =  158 bits (400), Expect = 4e-39,   Method: Compositional matrix adjust.
 Identities = 104/317 (32%), Positives = 169/317 (53%), Gaps = 33/317 (10%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLA 98
           Y   + +G G +  VF+A  + ++E  + K+L+   K+   RE++I+  ++  PN++ L 
Sbjct: 42  YTNCKVIGNGSFGVVFQAKLVESDEVAIKKVLQ--DKRFKNRELQIMRIVKH-PNVVDLK 98

Query: 99  DIV------KDPVSRTPALVFEHVNNTDFK------QLYQTLTDYDIRFYMYEILKALDY 146
                    KD V     LV E+V  T ++      +L QT+    I+ YMY++L++L Y
Sbjct: 99  AFFYSNGDKKDEVFLN--LVLEYVPETVYRASRHYAKLKQTMPMLLIKLYMYQLLRSLAY 156

Query: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDY 206
            HS+GI HRD+KP N+++D     L+LID+G A+    G+     + SRY++ PEL+   
Sbjct: 157 IHSIGICHRDIKPQNLLLDPPSGVLKLIDFGSAKILIAGEPNVSYICSRYYRAPELIFGA 216

Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIE-L 265
             Y  ++D+WS GC++A ++ + +P F G    DQLV I KVLGT    + I   N   +
Sbjct: 217 TNYTTNIDIWSTGCVMAELM-QGQPLFPGESGIDQLVEIIKVLGTPS-REQIKTMNPNYM 274

Query: 266 DPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFY 325
           + +F  I      K +        +    P+A+D + +LL Y   +RLTA EA+ HP+F 
Sbjct: 275 EHKFPQIRPHPFSKVF--------RPRTPPDAIDLISRLLEYTPSARLTAIEALCHPFF- 325

Query: 326 TVVKDQARMGSSSMPGG 342
               D+ R G + MP G
Sbjct: 326 ----DELRTGEARMPNG 338


>3OHT-A nrPDB
          Length = 389

 Score =  143 bits (360), Expect = 2e-34,   Method: Compositional matrix adjust.
 Identities = 99/334 (29%), Positives = 176/334 (52%), Gaps = 34/334 (10%)

Query: 7   SRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVV 66
           S A  +T  +  RP  ++  E +   W   + YQ +  +G G Y  V  + ++ +  K+ 
Sbjct: 22  SAAAPFTMSHKERPT-FYRQELNKTIWEVPERYQTLSPVGSGAYGSVCSSYDVKSGLKIA 80

Query: 67  VKIL-KP----VKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNN--- 118
           VK L +P    +  K+  RE+++L++++   N+I L D+       TPA   E  N+   
Sbjct: 81  VKKLSRPFQSIIHAKRTYRELRLLKHMKH-ENVIGLLDVF------TPATSLEEFNDVYL 133

Query: 119 ------TDFKQL--YQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRK 170
                  D   +   Q LTD  ++F +Y+IL+ L Y HS  I+HRD+KP N+ ++ E  +
Sbjct: 134 VTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCE 192

Query: 171 LRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKE 230
           L+++D+GLA   H   E    VA+R+++ PE+++++  Y+ ++D+WS+GC++A ++  + 
Sbjct: 193 LKILDFGLAR--HTDDEMTGYVATRWYRAPEIMLNWMHYNMTVDIWSVGCIMAELLTGRT 250

Query: 231 PFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQ 290
             F G D+ +QL +I ++ GT          + E     N +     R   + F+ +   
Sbjct: 251 -LFPGTDHINQLQQIMRLTGTPPASVISRMPSHEARNYINSLPQMPKRNFADVFIGA--- 306

Query: 291 HLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324
              +P A+D L+K+L  D   R+TA EA+ HPYF
Sbjct: 307 ---NPLAVDLLEKMLVLDTDKRITASEALAHPYF 337


>3NIZ-A nrPDB
          Length = 311

 Score =  142 bits (357), Expect = 3e-34,   Method: Compositional matrix adjust.
 Identities = 95/300 (31%), Positives = 158/300 (52%), Gaps = 22/300 (7%)

Query: 34  GNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIK----REIKILENLR 89
           G  + YQ + K+G G Y  V++A +       + +I    + + I     REI +L+ L 
Sbjct: 18  GLMEKYQKLEKVGEGTYGVVYKAKDSQGRIVALKRIRLDAEDEGIPSTAIREISLLKELH 77

Query: 90  GGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----LTDYDIRFYMYEILKALD 145
             PNI++L D++     R   LVFE +   D K++       L D  I+ Y+Y++L+ + 
Sbjct: 78  H-PNIVSLIDVIHS--ERCLTLVFEFMEK-DLKKVLDENKTGLQDSQIKIYLYQLLRGVA 133

Query: 146 YCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE-FYHPGQEYNVRVASRYFKGPELLV 204
           +CH   I+HRD+KP N++I+ +   L+L D+GLA  F  P + Y   V + +++ P++L+
Sbjct: 134 HCHQHRILHRDLKPQNLLINSDG-ALKLADFGLARAFGIPVRSYTHEVVTLWYRAPDVLM 192

Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIE 264
             + Y  S+D+WS+GC+ A MI  K P F G  + DQL +I  +LGT +  ++     + 
Sbjct: 193 GSKKYSTSVDIWSIGCIFAEMITGK-PLFPGVTDDDQLPKIFSILGTPNPREWPQVQELP 251

Query: 265 LDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324
           L  +         +K W   +    Q     E +D L  +L +D   R++AR+AM HPYF
Sbjct: 252 LWKQRT--FQVFEKKPWSSIIPGFCQ-----EGIDLLSNMLCFDPNKRISARDAMNHPYF 304


>4MYG-A nrPDB
          Length = 372

 Score =  141 bits (356), Expect = 4e-34,   Method: Compositional matrix adjust.
 Identities = 95/315 (30%), Positives = 167/315 (53%), Gaps = 20/315 (6%)

Query: 19  RPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL-KPVKK-- 75
           R + ++  + +   W     Y     +G G Y  V  AI+  + EKV +K L +P +   
Sbjct: 25  RKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEI 84

Query: 76  --KKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVN---NTDFKQLY-QTLT 129
             K+  RE+ +L++++   N+I L D+     S      F  V     TD +++     +
Sbjct: 85  FAKRAYRELLLLKHMQH-ENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFS 143

Query: 130 DYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYN 189
           +  I++ +Y++LK L Y HS G++HRD+KP N+ ++ E  +L+++D+GLA   H   E  
Sbjct: 144 EEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVN-EDCELKILDFGLAR--HADAEMT 200

Query: 190 VRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVL 249
             V +R+++ PE+++ +  Y+ ++D+WS+GC++A M+  K   F G D  DQL +I KV 
Sbjct: 201 GYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGK-TLFKGKDYLDQLTQILKVT 259

Query: 250 GTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDH 309
           G     +++ K N +    +   L +  RK + +          SP+A D L+K+L  D 
Sbjct: 260 GVPGT-EFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPR-----ASPQAADLLEKMLELDV 313

Query: 310 QSRLTAREAMEHPYF 324
             RLTA +A+ HP+F
Sbjct: 314 DKRLTAAQALTHPFF 328


>3GC9-A nrPDB
          Length = 370

 Score =  141 bits (355), Expect = 6e-34,   Method: Compositional matrix adjust.
 Identities = 97/313 (30%), Positives = 164/313 (52%), Gaps = 43/313 (13%)

Query: 33  WGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL-KP----VKKKKIKREIKILEN 87
           W      Q +R +G G Y  V  A +    +KV VK L +P    +  ++  RE+++L++
Sbjct: 24  WEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKH 83

Query: 88  LRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY----------------QTLTDY 131
           L+   N+I L D+       TPA   E     DF ++Y                Q L+D 
Sbjct: 84  LKH-ENVIGLLDVF------TPATSIE-----DFSEVYLVTTLMGADLNNIVKSQALSDE 131

Query: 132 DIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVR 191
            ++F +Y++L+ L Y HS GI+HRD+KP NV ++ E  +LR++D+GLA      +E    
Sbjct: 132 HVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVN-EDSELRILDFGLAR--QADEEMTGY 188

Query: 192 VASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGT 251
           VA+R+++ PE+++++  Y+ ++D+WS+GC++A ++ + +  F G D  DQL RI +V+GT
Sbjct: 189 VATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELL-QGKALFPGSDYIDQLKRIMEVVGT 247

Query: 252 EDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQS 311
               + + K + E    +   L    +K         N     P A+D L ++L  D   
Sbjct: 248 PS-PEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGAN-----PLAIDLLGRMLVLDSDQ 301

Query: 312 RLTAREAMEHPYF 324
           R++A EA+ H YF
Sbjct: 302 RVSAAEALAHAYF 314


>1V0B-A nrPDB
          Length = 288

 Score =  140 bits (353), Expect = 1e-33,   Method: Compositional matrix adjust.
 Identities = 90/298 (30%), Positives = 162/298 (54%), Gaps = 25/298 (8%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK-----IKREIKILENLRGG 91
           + Y  + K+G G Y  V++A N    E   +K ++  K+ +       REI IL+ L+  
Sbjct: 2   EKYHGLEKIGEGTYGVVYKAQN-NYGETFALKKIRLEKEDEGIPSTTIREISILKELKHS 60

Query: 92  PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----LTDYDIRFYMYEILKALDYC 147
            NI+ L D++     +   LVFEH++  D K+L       L     + ++ ++L  + YC
Sbjct: 61  -NIVKLYDVIH--TKKRLVLVFEHLDQ-DLKKLLDVCEGGLESVTAKSFLLQLLNGIAYC 116

Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE-FYHPGQEYNVRVASRYFKGPELLVDY 206
           H   ++HRD+KP N++I+ E  +L++ D+GLA  F  P ++Y   V + +++ P++L+  
Sbjct: 117 HDRRVLHRDLKPQNLLINREG-ELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVLMGS 175

Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 266
           + Y  ++D+WS+GC+ A M+    P F G    DQL+RI ++LGT +  ++    N+   
Sbjct: 176 KKYSTTIDIWSVGCIFAEMV-NGAPLFPGVSEADQLMRIFRILGTPNSKNWP---NVTEL 231

Query: 267 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324
           P+++     +    WE F+   ++       +D L K+L+ D   R+TA++A+EH YF
Sbjct: 232 PKYDPNFTVYEPLPWESFLKGLDE-----SGIDLLSKMLKLDPNQRITAKQALEHAYF 284


>2BPM-A nrPDB
          Length = 309

 Score =  140 bits (352), Expect = 1e-33,   Method: Compositional matrix adjust.
 Identities = 95/307 (30%), Positives = 163/307 (53%), Gaps = 27/307 (8%)

Query: 35  NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK------PVKKKKIKREIKILENL 88
           + +++Q V K+G G Y  V++A N    E V +K ++       V    I REI +L+ L
Sbjct: 5   DMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAI-REISLLKEL 63

Query: 89  RGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY--QTLTDYD---IRFYMYEILKA 143
              PNI+ L D++         LVFE ++  D K+      LT      I+ Y++++L+ 
Sbjct: 64  -NHPNIVKLLDVIH--TENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQG 119

Query: 144 LDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE-FYHPGQEYNVRVASRYFKGPEL 202
           L +CHS  ++HRD+KP N++I+ E   ++L D+GLA  F  P + Y   V + +++ PE+
Sbjct: 120 LAFCHSHRVLHRDLKPQNLLINTEG-AIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEI 178

Query: 203 LVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYN 262
           L+  + Y  ++D+WSLGC+ A M+ R+   F G    DQL RI + LGT D   +    +
Sbjct: 179 LLGCKYYSTAVDIWSLGCIFAEMVTRRA-LFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS 237

Query: 263 IELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHP 322
           +   P +     + +R+ + + V   ++     +    L ++L YD   R++A+ A+ HP
Sbjct: 238 M---PDYKPSFPKWARQDFSKVVPPLDE-----DGRSLLSQMLHYDPNKRISAKAALAHP 289

Query: 323 YFYTVVK 329
           +F  V K
Sbjct: 290 FFQDVTK 296


>1CM8-A nrPDB
          Length = 367

 Score =  140 bits (352), Expect = 1e-33,   Method: Compositional matrix adjust.
 Identities = 100/343 (29%), Positives = 177/343 (51%), Gaps = 45/343 (13%)

Query: 1   MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINIT 60
           MS P P+R+  Y              E     W  +  Y+ ++ +G G Y  V  A++  
Sbjct: 1   MSSPPPARSGFYRQ------------EVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGR 48

Query: 61  NNEKVVVKIL-KPVKK----KKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEH 115
              KV +K L +P +     K+  RE+++L+++R   N+I L D+       TP    + 
Sbjct: 49  TGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRH-ENVIGLLDVF------TPDETLDD 101

Query: 116 VNN---------TDFKQL--YQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMI 164
             +         TD  +L  ++ L +  I+F +Y++LK L Y H+ GI+HRD+KP N+ +
Sbjct: 102 FTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAV 161

Query: 165 DHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLAS 224
           + E  +L+++D+GLA       E    V +R+++ PE+++++  Y  ++D+WS+GC++A 
Sbjct: 162 N-EDCELKILDFGLAR--QADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAE 218

Query: 225 MIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERF 284
           MI  K   F G D+ DQL  I KV GT    +++ +   +    +   L    +K +   
Sbjct: 219 MITGK-TLFKGSDHLDQLKEIMKVTGTPPA-EFVQRLQSDEAKNYMKGLPELEKKDFASI 276

Query: 285 VHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTV 327
           + +      SP A++ L+K+L  D + R+TA EA+ HPYF ++
Sbjct: 277 LTN-----ASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESL 314


>5AIR-A nrPDB
          Length = 430

 Score =  139 bits (349), Expect = 3e-33,   Method: Compositional matrix adjust.
 Identities = 115/370 (31%), Positives = 178/370 (48%), Gaps = 48/370 (12%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIK-REIKILENLRGGPNIITL 97
           Y   + +G G +  V++A    + E V +K  K ++ K+ K RE++I+  L    NI+ L
Sbjct: 66  YTDTKVIGNGSFGVVYQAKLCDSGELVAIK--KVLQDKRFKNRELQIMRKLDHC-NIVRL 122

Query: 98  ------ADIVKDPVSRTPALVFEHVNNTDFK------QLYQTLTDYDIRFYMYEILKALD 145
                 +   KD V     LV ++V  T ++      +  QTL    ++ YMY++ ++L 
Sbjct: 123 RYFFYSSGEKKDEVYLN--LVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLA 180

Query: 146 YCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVD 205
           Y HS GI HRD+KP N+++D +   L+L D+G A+    G+     + SRY++ PEL+  
Sbjct: 181 YIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFG 240

Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNI-E 264
              Y  S+D+WS GC+LA ++   +P F G    DQLV I KVLGT        +  I E
Sbjct: 241 ATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTP------TREQIRE 293

Query: 265 LDPRFNDI-LGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323
           ++P + +    +     W +           PEA+    +LL Y   +RLT  EA  H +
Sbjct: 294 MNPNYTEFKFPQIKAHPWTKVFRPRT----PPEAIALCSRLLEYTPTARLTPLEACAHSF 349

Query: 324 FYTVVKDQARMGSSSMPGG-STPVSSANMMSGISSVPTPSPLGPLAGSP---VIAAANPL 379
           F     D+ R  +  +P G  TP         +SS P   PL  +   P   + AAA+P 
Sbjct: 350 F-----DELRDPNVKLPNGRDTPALFNFTTQELSSNP---PLATILIPPHARIQAAASP- 400

Query: 380 GMPVPAAAGA 389
               PA A A
Sbjct: 401 ----PANATA 406


>6GU6-A nrPDB
          Length = 302

 Score =  139 bits (349), Expect = 3e-33,   Method: Compositional matrix adjust.
 Identities = 93/304 (30%), Positives = 163/304 (53%), Gaps = 28/304 (9%)

Query: 34  GNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK-----IKREIKILENL 88
           G+ +DY  + K+G G Y  V++  + T  + V +K ++   +++       REI +L+ L
Sbjct: 4   GSMEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKEL 63

Query: 89  RGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY------QTLTDYDIRFYMYEILK 142
           R  PNI++L D++    SR   L+FE ++  D K+        Q +    ++ Y+Y+IL+
Sbjct: 64  RH-PNIVSLQDVLMQD-SRL-YLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQILQ 119

Query: 143 ALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE-FYHPGQEYNVRVASRYFKGPE 201
            + +CHS  ++HRD+KP N++ID +   ++L D+GLA  F  P + Y   V + +++ PE
Sbjct: 120 GIVFCHSRRVLHRDLKPQNLLID-DKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPE 178

Query: 202 LLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKY 261
           +L+    Y   +D+WS+G + A +  +K P FHG    DQL RI + LGT          
Sbjct: 179 VLLGSARYSTPVDIWSIGTIFAELATKK-PLFHGDSEIDQLFRIFRALGTP--------- 228

Query: 262 NIELDPRFNDILG-RHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAME 320
           N E+ P    +   +++  +W+    + +   +    LD L K+L YD   R++ + A+ 
Sbjct: 229 NNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALN 288

Query: 321 HPYF 324
           HPYF
Sbjct: 289 HPYF 292


>4EWQ-A nrPDB
          Length = 383

 Score =  137 bits (346), Expect = 6e-33,   Method: Compositional matrix adjust.
 Identities = 96/328 (29%), Positives = 172/328 (52%), Gaps = 34/328 (10%)

Query: 13  TDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL-K 71
           ++ +  RP  ++  E +   W   + YQ +  +G G Y  V  A +     +V VK L +
Sbjct: 22  SNASQERPT-FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSR 80

Query: 72  P----VKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNN--------- 118
           P    +  K+  RE+++L++++   N+I L D+       TPA   E  N+         
Sbjct: 81  PFQSIIHAKRTYRELRLLKHMKH-ENVIGLLDVF------TPARSLEEFNDVYLVTHLMG 133

Query: 119 TDFKQLY--QTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDW 176
            D   +   Q LTD  ++F +Y+IL+ L Y HS  I+HRD+KP N+ ++ E  +L+++D+
Sbjct: 134 ADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCELKILDF 192

Query: 177 GLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGH 236
           GLA   H   E    VA+R+++ PE+++++  Y+ ++D+WS+GC++A ++  +   F G 
Sbjct: 193 GLAR--HTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGR-TLFPGT 249

Query: 237 DNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPE 296
           D+ DQL  I +++GT    + + K + E    +   L +  +  +       N     P 
Sbjct: 250 DHIDQLKLILRLVGTPGA-ELLKKISSESARNYIQSLTQMPKMNFANVFIGAN-----PL 303

Query: 297 ALDFLDKLLRYDHQSRLTAREAMEHPYF 324
           A+D L+K+L  D   R+TA +A+ H YF
Sbjct: 304 AVDLLEKMLVLDSDKRITAAQALAHAYF 331


>4KRC-A nrPDB
          Length = 317

 Score =  136 bits (342), Expect = 2e-32,   Method: Compositional matrix adjust.
 Identities = 91/316 (28%), Positives = 170/316 (53%), Gaps = 27/316 (8%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIK----REIKILENLRGGPNI 94
           ++ + KLG G Y+ V++ +N T    V +K +K   ++       REI +++ L+   NI
Sbjct: 7   FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKH-ENI 65

Query: 95  ITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYD---------IRFYMYEILKALD 145
           + L D++      T  LVFE ++N D K+   + T  +         ++++ +++L+ L 
Sbjct: 66  VRLYDVIHTENKLT--LVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLA 122

Query: 146 YCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE-FYHPGQEYNVRVASRYFKGPELLV 204
           +CH   I+HRD+KP N++I+ +  +L+L D+GLA  F  P   ++  V + +++ P++L+
Sbjct: 123 FCHENKILHRDLKPQNLLIN-KRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLM 181

Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGT--EDLYDYIDKYN 262
             + Y  S+D+WS GC+LA MI  K P F G ++ +QL  I  ++GT  E L+  + K  
Sbjct: 182 GSRTYSTSIDIWSCGCILAEMITGK-PLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKL- 239

Query: 263 IELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHP 322
               P++N  + +   +   + +    +  +    +DFL  LL+ +   RL+A++A+ HP
Sbjct: 240 ----PKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHP 295

Query: 323 YFYTVVKDQARMGSSS 338
           +F       +  GS S
Sbjct: 296 WFAEYYHHASMGGSRS 311


>1UA2-A nrPDB
          Length = 346

 Score =  135 bits (340), Expect = 3e-32,   Method: Compositional matrix adjust.
 Identities = 97/304 (31%), Positives = 162/304 (53%), Gaps = 38/304 (12%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIK--------REIKILENLRG 90
           Y+ +  LG G+++ V++A +   N+ V +K +K   + + K        REIK+L+ L  
Sbjct: 12  YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL-S 70

Query: 91  GPNIITLADIV--KDPVSRTPALVFEHVNNTDFKQLYQ----TLTDYDIRFYMYEILKAL 144
            PNII L D    K  +S    LVF+ +  TD + + +     LT   I+ YM   L+ L
Sbjct: 71  HPNIIGLLDAFGHKSNIS----LVFDFME-TDLEVIIKDNSLVLTPSHIKAYMLMTLQGL 125

Query: 145 DYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE-FYHPGQEYNVRVASRYFKGPELL 203
           +Y H   I+HRD+KP+N+++D E+  L+L D+GLA+ F  P + Y  +V +R+++ PELL
Sbjct: 126 EYLHQHWILHRDLKPNNLLLD-ENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELL 184

Query: 204 VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNI 263
              +MY   +DMW++GC+LA ++ R  PF  G  + DQL RI + LGT            
Sbjct: 185 FGARMYGVGVDMWAVGCILAELLLRV-PFLPGDSDLDQLTRIFETLGTPT---------- 233

Query: 264 ELDPRFNDILGRHSRKRWERFVHSENQHLVSP---EALDFLDKLLRYDHQSRLTAREAME 320
             + ++ D+        ++ F      H+ S    + LD +  L  ++  +R+TA +A++
Sbjct: 234 --EEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALK 291

Query: 321 HPYF 324
             YF
Sbjct: 292 MKYF 295


>5NGU-A nrPDB
          Length = 381

 Score =  133 bits (334), Expect = 2e-31,   Method: Compositional matrix adjust.
 Identities = 93/297 (31%), Positives = 158/297 (53%), Gaps = 31/297 (10%)

Query: 45  LGRGKYSEVFEAINITNNEKVVVKILKPVKKK----KIKREIKILENLRGGPNIITLADI 100
           +G G Y  V  A +  N  +V +K + P + +    +  REIKIL   R   NII + DI
Sbjct: 50  IGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRH-ENIIGINDI 108

Query: 101 VKDPV--SRTPALVFEHVNNTDFKQLYQT--LTDYDIRFYMYEILKALDYCHSMGIMHRD 156
           ++ P         + + +  TD  +L +T  L++  I +++Y+IL+ L Y HS  ++HRD
Sbjct: 109 IRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRD 168

Query: 157 VKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEY----NVRVASRYFKGPELLVDYQMYDYS 212
           +KP N++++     L++ D+GLA    P  ++       VA+R+++ PE++++ + Y  S
Sbjct: 169 LKPSNLLLNTTC-DLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKS 227

Query: 213 LDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGT---EDLYDYIDKYNIELDPRF 269
           +D+WS+GC+LA M+  + P F G    DQL  I  +LG+   EDL   I+     L  R 
Sbjct: 228 IDIWSVGCILAEMLSNR-PIFPGKHYLDQLNHILGILGSPSQEDLNCIIN-----LKAR- 280

Query: 270 NDILGRHSRKR--WERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324
           N +L    + +  W R   + +      +ALD LDK+L ++   R+   +A+ HPY 
Sbjct: 281 NYLLSLPHKNKVPWNRLFPNADS-----KALDLLDKMLTFNPHKRIEVEQALAHPYL 332


>4QNY-A nrPDB
          Length = 354

 Score =  132 bits (332), Expect = 2e-31,   Method: Compositional matrix adjust.
 Identities = 94/309 (30%), Positives = 159/309 (51%), Gaps = 38/309 (12%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK---------KKIKREIKILEN 87
           D Y L R +G G Y  V  A +  ++ ++V   +K V K         K+I REIK+L +
Sbjct: 20  DRYLLERIIGAGSYGVVIRARDTKSDNRLVA--MKRVNKEIFEEVILAKRILREIKLLAH 77

Query: 88  LRGGPNIITLADIV--KDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILK 142
                NII L +I+  +DP +     +   +  TD KQ+    Q LT+  I+F++Y+ L+
Sbjct: 78  F-NDDNIIGLRNILTPEDPENFDHFYIVMDIMETDLKQVLRSGQELTEAHIQFFIYQALR 136

Query: 143 ALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVR-VASRYFKGPE 201
           AL   HS G++HRD+ P N++++  +  L++ D+GLA+  +   EY    V  R+++ PE
Sbjct: 137 ALHIIHSAGVIHRDITPANILVN-TNCDLKICDFGLAKEENDQGEYMTDYVTMRWYRAPE 195

Query: 202 LLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKY 261
           L+++ + Y   +D+W +GC+L  ++  + P F G D  +QL +I  V+GT    D     
Sbjct: 196 LVMEDKDYSAQIDVWGIGCILGELLGSR-PLFQGKDRVNQLDKIVDVIGTPSEED----- 249

Query: 262 NIELDPRFNDILGRHSRKRWERFVHSENQH------LVSPEALDFLDKLLRYDHQSRLTA 315
                   N +    ++K  ++  H             SPEALD L  +L ++ + R+T 
Sbjct: 250 -------INSVGSSAAQKYLKKKSHRPQADWRQRYPTASPEALDLLRHMLVFNPKRRITV 302

Query: 316 REAMEHPYF 324
            +AM HP+ 
Sbjct: 303 LQAMRHPFL 311


>2F9G-A nrPDB
          Length = 353

 Score =  131 bits (330), Expect = 4e-31,   Method: Compositional matrix adjust.
 Identities = 96/311 (30%), Positives = 163/311 (52%), Gaps = 33/311 (10%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK----KIKREIKILENLRGGPN 93
           D+QL   LG G Y  V  A +    E V +K ++P  K     +  REIKIL++ +   N
Sbjct: 12  DFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHE-N 70

Query: 94  IITLADIVK-DPVSR-TPALVFEHVNNTDFKQLYQT--LTDYDIRFYMYEILKALDYCHS 149
           IIT+ +I + D         + + +  TD  ++  T  L+D  I++++Y+ L+A+   H 
Sbjct: 71  IITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHG 130

Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH---------PGQEYNVR--VASRYFK 198
             ++HRD+KP N++I+  +  L++ D+GLA              GQ+  +   VA+R+++
Sbjct: 131 SNVIHRDLKPSNLLIN-SNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYR 189

Query: 199 GPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYI 258
            PE+++    Y  ++D+WS GC+LA +  R+ P F G D   QL+ I  ++GT   +   
Sbjct: 190 APEVMLTSAKYSRAMDVWSCGCILAELFLRR-PIFPGRDYRHQLLLIFGIIGTP--HSDN 246

Query: 259 DKYNIELDPRFNDILGRHSRKRWERFVHSENQHL---VSPEALDFLDKLLRYDHQSRLTA 315
           D   IE  PR      R   K    +  +  + +   V+P+ +D L ++L +D   R+TA
Sbjct: 247 DLRCIE-SPR-----AREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITA 300

Query: 316 REAMEHPYFYT 326
           +EA+EHPY  T
Sbjct: 301 KEALEHPYLQT 311


>4AU8-A nrPDB
          Length = 296

 Score =  131 bits (330), Expect = 4e-31,   Method: Compositional matrix adjust.
 Identities = 95/303 (31%), Positives = 163/303 (53%), Gaps = 37/303 (12%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILK------PVKKKKIKREIKILENLRGGP 92
           Y+ + K+G G Y  VF+A N   +E V +K ++       V    + REI +L+ L+   
Sbjct: 8   YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSAL-REICLLKELKHK- 65

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLT-DYD---IRFYMYEILKALDYCH 148
           NI+ L D++      T  LVFE  +  D K+ + +   D D   ++ +++++LK L +CH
Sbjct: 66  NIVRLHDVLHSDKKLT--LVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCH 122

Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE-FYHPGQEYNVRVASRYFKGPELLVDYQ 207
           S  ++HRD+KP N++I+  + +L+L D+GLA  F  P + Y+  V + +++ P++L   +
Sbjct: 123 SRNVLHRDLKPQNLLINR-NGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAK 181

Query: 208 MYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLG--TEDLYDYIDKYNIEL 265
           +Y  S+DMWS GC+ A +     P F G+D  DQL RI ++LG  TE+ +  + K     
Sbjct: 182 LYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKL---- 237

Query: 266 DPRFNDILGRHSRKRWERFVHSENQHLVSPE----ALDFLDKLLRYDHQSRLTAREAMEH 321
            P +         K +  +  + +   V P+      D L  LL+ +   R++A EA++H
Sbjct: 238 -PDY---------KPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQH 287

Query: 322 PYF 324
           PYF
Sbjct: 288 PYF 290


>4QTB-A nrPDB
          Length = 380

 Score =  131 bits (330), Expect = 4e-31,   Method: Compositional matrix adjust.
 Identities = 86/298 (28%), Positives = 155/298 (52%), Gaps = 21/298 (7%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK----KIKREIKILENLRGGPNI 94
           Y  ++ +G G Y  V  A +     +V +K + P + +    +  REI+IL   R   N+
Sbjct: 43  YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRH-ENV 101

Query: 95  ITLADIVKDPV--SRTPALVFEHVNNTDFKQLY--QTLTDYDIRFYMYEILKALDYCHSM 150
           I + DI++     +     + + +  TD  +L   Q L++  I +++Y+IL+ L Y HS 
Sbjct: 102 IGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSA 161

Query: 151 GIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEY----NVRVASRYFKGPELLVDY 206
            ++HRD+KP N++I+     L++ D+GLA    P  ++       VA+R+++ PE++++ 
Sbjct: 162 NVLHRDLKPSNLLINTTC-DLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNS 220

Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 266
           + Y  S+D+WS+GC+LA M+  + P F G    DQL  I  +LG+    D     N++  
Sbjct: 221 KGYTKSIDIWSVGCILAEMLSNR-PIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKAR 279

Query: 267 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324
             +   L   ++  W +     +      +ALD LD++L ++   R+T  EA+ HPY 
Sbjct: 280 -NYLQSLPSKTKVAWAKLFPKSDS-----KALDLLDRMLTFNPNKRITVEEALAHPYL 331


>3EB0-A nrPDB
          Length = 383

 Score =  131 bits (329), Expect = 5e-31,   Method: Compositional matrix adjust.
 Identities = 63/193 (32%), Positives = 110/193 (56%), Gaps = 11/193 (5%)

Query: 133 IRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRV 192
           I  Y+Y++ +A+ + HS+GI HRD+KP N++++ +   L+L D+G A+   P +     +
Sbjct: 143 ISIYIYQLFRAVGFIHSLGICHRDIKPQNLLVNSKDNTLKLCDFGSAKKLIPSEPSVAYI 202

Query: 193 ASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTE 252
            SR+++ PEL++    Y  S+D+WS+GC+   +I  K P F G  + DQLVRI +++GT 
Sbjct: 203 CSRFYRAPELMLGATEYTPSIDLWSIGCVFGELILGK-PLFSGETSIDQLVRIIQIMGTP 261

Query: 253 DLYDYIDKYNIELDPRFNDI-LGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQS 311
                  +  I ++P + ++       K W + +      L    A+D L+++LRY+   
Sbjct: 262 -----TKEQMIRMNPHYTEVRFPTLKAKDWRKILPEGTPSL----AIDLLEQILRYEPDL 312

Query: 312 RLTAREAMEHPYF 324
           R+   EAM HP+F
Sbjct: 313 RINPYEAMAHPFF 325


>3OZ6-A nrPDB
          Length = 388

 Score =  130 bits (328), Expect = 7e-31,   Method: Compositional matrix adjust.
 Identities = 95/329 (28%), Positives = 166/329 (50%), Gaps = 52/329 (15%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKIL-----KPVKKKKIKREIKILENLRGGPN 93
           Y+LV+KLG+G Y  V+++I+    E V VK +          ++  REI IL  L G  N
Sbjct: 11  YELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIFDAFQNSTDAQRTFREIMILTELSGHEN 70

Query: 94  IITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT--LTDYDIRFYMYEILKALDYCHSMG 151
           I+ L ++++    R   LVF+++  TD   + +   L     ++ +Y+++K + Y HS G
Sbjct: 71  IVNLLNVLRADNDRDVYLVFDYME-TDLHAVIRANILEPVHKQYVVYQLIKVIKYLHSGG 129

Query: 152 IMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVR-------------------- 191
           ++HRD+KP N++++ E   +++ D+GL+  +      N+R                    
Sbjct: 130 LLHRDMKPSNILLNAECH-VKVADFGLSRSF-----VNIRRVTNNIPLSINENTENFDDD 183

Query: 192 -------VASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVR 244
                  VA+R+++ PE+L+    Y   +DMWSLGC+L  ++  K P F G    +QL R
Sbjct: 184 QPILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGK-PIFPGSSTMNQLER 242

Query: 245 IAKVL---GTEDLYDYIDKYNIELDPRFND-ILGRHSRKR-----WERFVHSEN-QHLVS 294
           I  V+     ED+      +   +     + +  R S KR     W+  +   N +   +
Sbjct: 243 IIGVIDFPSNEDVESIQSPFAKTMIESLKEKVEIRQSNKRDIFTKWKNLLLKINPKADCN 302

Query: 295 PEALDFLDKLLRYDHQSRLTAREAMEHPY 323
            EALD LDKLL+++   R++A +A++HP+
Sbjct: 303 EEALDLLDKLLQFNPNKRISANDALKHPF 331


>6DTL-A nrPDB
          Length = 364

 Score =  130 bits (326), Expect = 1e-30,   Method: Compositional matrix adjust.
 Identities = 84/302 (27%), Positives = 157/302 (51%), Gaps = 32/302 (10%)

Query: 42  VRKLGRGKYSEVFEAINITNNEKVVVKIL-----KPVKKKKIKREIKILENLRGGPNIIT 96
           +  +G+G Y  V  A+N   NE V +K +       +  K+  REIK+L ++    NI+ 
Sbjct: 35  IMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHM-DHENIVA 93

Query: 97  LADIVKDPVSRTPALVF--EHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCHSMG 151
           + DI+  P+      V+    + +TD  Q+    Q L++   ++++Y+IL+ L Y HS  
Sbjct: 94  IRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSAN 153

Query: 152 IMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDY 211
           ++HRD+KP N++++  +  L++ D+GLA            V +R+++ PELL++   Y  
Sbjct: 154 VLHRDLKPSNLLLN-ANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTA 212

Query: 212 SLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYI------DKYNIEL 265
           ++D+WS+GC+   ++ RK P F G D+  QL  + +++GT    +         +Y  +L
Sbjct: 213 AIDVWSVGCIFMELMDRK-PLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQL 271

Query: 266 DPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFY 325
            P             + R   ++    V P A+D ++K+L +D + R+T  +A+ HPY  
Sbjct: 272 PP-------------YPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLN 318

Query: 326 TV 327
           ++
Sbjct: 319 SL 320


>1G3N-A nrPDB
          Length = 326

 Score =  128 bits (321), Expect = 5e-30,   Method: Compositional matrix adjust.
 Identities = 98/333 (29%), Positives = 161/333 (48%), Gaps = 52/333 (15%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK--------KIKREIKILENLRG 90
           Y+ V ++G G Y +VF+A ++ N  + V   LK V+ +           RE+ +L +L  
Sbjct: 13  YECVAEIGEGAYGKVFKARDLKNGGRFVA--LKRVRVQTGEEGMPLSTIREVAVLRHLET 70

Query: 91  --GPNIITLADIVKDPVSRTP-----ALVFEHVNNTDFKQLYQTLTDY------------ 131
              PN++ L D+    VSRT       LVFEHV+        Q LT Y            
Sbjct: 71  FEHPNVVRLFDVCT--VSRTDRETKLTLVFEHVD--------QDLTTYLDKVPEPGVPTE 120

Query: 132 DIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVR 191
            I+  M+++L+ LD+ HS  ++HRD+KP N+++     +++L D+GLA  Y         
Sbjct: 121 TIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSG-QIKLADFGLARIYSFQMALTSV 179

Query: 192 VASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGT 251
           V + +++ PE+L+    Y   +D+WS+GC+ A M FR++P F G  + DQL +I  V+G 
Sbjct: 180 VVTLWYRAPEVLLQSS-YATPVDLWSVGCIFAEM-FRRKPLFRGSSDVDQLGKILDVIGL 237

Query: 252 EDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQS 311
               D+     +   PR        S +  E+FV       +     D L K L ++   
Sbjct: 238 PGEEDWPRDVAL---PR--QAFHSKSAQPIEKFVTD-----IDELGKDLLLKCLTFNPAK 287

Query: 312 RLTAREAMEHPYFYTVVKDQARMGSSSMPGGST 344
           R++A  A+ HPYF  + + +  + S   P  +T
Sbjct: 288 RISAYSALSHPYFQDLERCKENLDSHLPPSQNT 320


>4AGU-A nrPDB
          Length = 311

 Score =  126 bits (317), Expect = 1e-29,   Method: Compositional matrix adjust.
 Identities = 92/315 (29%), Positives = 156/315 (49%), Gaps = 36/315 (11%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL-----KPVKKKKIKREIKILENLRGG 91
           + Y+ + K+G G Y  VF+  N    + V +K        PV KK   REI++L+ L+  
Sbjct: 3   EKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKH- 61

Query: 92  PNIITLADIVKDPVSRTPALVFEHVNNTDFKQL--YQT-LTDYDIRFYMYEILKALDYCH 148
           PN++ L ++ +    R   LVFE+ ++T   +L  YQ  + ++ ++   ++ L+A+++CH
Sbjct: 62  PNLVNLLEVFRR--KRRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFCH 119

Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH-PGQEYNVRVASRYFKGPELLVDYQ 207
               +HRDVKP N++I  +H  ++L D+G A     P   Y+  VA+R+++ PELLV   
Sbjct: 120 KHNCIHRDVKPENILIT-KHSVIKLCDFGFARLLTGPSDYYDDEVATRWYRSPELLVGDT 178

Query: 208 MYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDP 267
            Y   +D+W++GC+ A ++    P + G  + DQL  I K LG             +L P
Sbjct: 179 QYGPPVDVWAIGCVFAELL-SGVPLWPGKSDVDQLYLIRKTLG-------------DLIP 224

Query: 268 RFNDILGRHSRKRWERFVHSENQHL-------VSPEALDFLDKLLRYDHQSRLTAREAME 320
           R   +   +      +    E+          +S  AL  L   L  D   RLT  + + 
Sbjct: 225 RHQQVFSTNQYFSGVKIPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTERLTCEQLLH 284

Query: 321 HPYFYTV--VKDQAR 333
           HPYF  +  ++D A+
Sbjct: 285 HPYFENIREIEDLAK 299


>3GC0-A nrPDB
          Length = 329

 Score =  124 bits (312), Expect = 6e-29,   Method: Compositional matrix adjust.
 Identities = 85/301 (28%), Positives = 153/301 (50%), Gaps = 25/301 (8%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK-----IKREIKILENLRGG 91
           D Y+ + KLG G Y EV++AI+   NE V +K ++   +++       RE+ +L+ L+  
Sbjct: 34  DRYRRITKLGEGTYGEVYKAIDTVTNETVAIKRIRLEHEEEGVPGTAIREVSLLKELQHR 93

Query: 92  PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRF---YMYEILKALDYCH 148
            NII L  ++    +    L+FE+  N D K+      D  +R    ++Y+++  +++CH
Sbjct: 94  -NIIELKSVIHH--NHRLHLIFEYAEN-DLKKYMDKNPDVSMRVIKSFLYQLINGVNFCH 149

Query: 149 SMGIMHRDVKPHNVMID----HEHRKLRLIDWGLAE-FYHPGQEYNVRVASRYFKGPELL 203
           S   +HRD+KP N+++      E   L++ D+GLA  F  P +++   + + +++ PE+L
Sbjct: 150 SRRCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQFTHEIITLWYRPPEIL 209

Query: 204 VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNI 263
           +  + Y  S+D+WS+ C+ A M+  K P F G    DQL +I +VLG  D   +     +
Sbjct: 210 LGSRHYSTSVDIWSIACIWAEMLM-KTPLFPGDSEIDQLFKIFEVLGLPDDTTW---PGV 265

Query: 264 ELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323
              P +     +   K  +R + +                +L  D   R++A+ A+EHPY
Sbjct: 266 TALPDWKQSFPKFRGKTLKRVLGALLDDEGLDLL----TAMLEMDPVKRISAKNALEHPY 321

Query: 324 F 324
           F
Sbjct: 322 F 322


>4IC8-A nrPDB
          Length = 442

 Score =  124 bits (311), Expect = 7e-29,   Method: Compositional matrix adjust.
 Identities = 86/307 (28%), Positives = 155/307 (50%), Gaps = 31/307 (10%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP-----VKKKKIKREIKILENLRGG 91
           D+Y+++  +G G Y  V  A      ++V +K +          K+  RE+KIL++ +  
Sbjct: 55  DEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHD 114

Query: 92  PNIITLADIVKDPV---SRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALD 145
            NII + DI++  V         V   +  +D  Q+    Q LT   +R+++Y++L+ L 
Sbjct: 115 -NIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLK 173

Query: 146 YCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGL--------AEFYHPGQEYNVRVASRYF 197
           Y HS  ++HRD+KP N++++ E+ +L++ D+G+        AE  +   EY   VA+R++
Sbjct: 174 YMHSAQVIHRDLKPSNLLVN-ENCELKIGDFGMARGLCTSPAEHQYFMTEY---VATRWY 229

Query: 198 KGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDY 257
           + PEL++    Y  ++D+WS+GC+   M+ R++  F G +   QL  I  VLGT      
Sbjct: 230 RAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQ-LFPGKNYVHQLQLIMMVLGTPS-PAV 287

Query: 258 IDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTARE 317
           I     E    +   L       WE      ++     +AL  L ++LR++  +R++A  
Sbjct: 288 IQAVGAERVRAYIQSLPPRQPVPWETVYPGADR-----QALSLLGRMLRFEPSARISAAA 342

Query: 318 AMEHPYF 324
           A+ HP+ 
Sbjct: 343 ALRHPFL 349


>5G6V-A nrPDB
          Length = 324

 Score =  123 bits (308), Expect = 2e-28,   Method: Compositional matrix adjust.
 Identities = 86/303 (28%), Positives = 164/303 (54%), Gaps = 28/303 (9%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK----KIKREIKILENLRGGP 92
           + Y  + KLG G Y+ V++  +   +  V +K ++   ++       RE+ +L++L+   
Sbjct: 2   ETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHA- 60

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTD-------YDIRFYMYEILKALD 145
           NI+TL DI+    S T  LVFE+++    K L Q L D       ++++ +++++L+ L 
Sbjct: 61  NIVTLHDIIHTEKSLT--LVFEYLD----KDLKQYLDDCGNIINMHNVKLFLFQLLRGLA 114

Query: 146 YCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH-PGQEYNVRVASRYFKGPELLV 204
           YCH   ++HRD+KP N++I+ E  +L+L D+GLA     P + Y+  V + +++ P++L+
Sbjct: 115 YCHRQKVLHRDLKPQNLLIN-ERGELKLADFGLARAKSIPTKTYDNEVVTLWYRPPDILL 173

Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIE 264
               Y   +DMW +GC+   M   + P F G    +QL  I ++LGT     +    + E
Sbjct: 174 GSTDYSTQIDMWGVGCIFYEMATGR-PLFPGSTVEEQLHFIFRILGTPTEETWPGILSNE 232

Query: 265 LDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324
               +N     + + R E  +    +  +  +  D L KLL+++ ++R++A +AM+HP+F
Sbjct: 233 EFKTYN-----YPKYRAEALLSHAPR--LDSDGADLLTKLLQFEGRNRISAEDAMKHPFF 285

Query: 325 YTV 327
            ++
Sbjct: 286 LSL 288


>5EFQ-A nrPDB
          Length = 347

 Score =  122 bits (306), Expect = 2e-28,   Method: Compositional matrix adjust.
 Identities = 89/319 (27%), Positives = 161/319 (50%), Gaps = 34/319 (10%)

Query: 31  VEWGNQ--DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK-----IKREIK 83
           ++WG +  D + ++  +G G Y +V++A +    E V +K ++   +K+       REIK
Sbjct: 3   IDWGKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIK 62

Query: 84  ILENLRGGPNIITLADIVKDPVSRTPA--------LVFEHVNNTDFKQLYQTLTDYD--- 132
           IL  L    +II + +IV D               LVFE++++     L   L  ++   
Sbjct: 63  ILRQL-THQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENH 121

Query: 133 IRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE--YNV 190
           I+ +M ++++ LDYCH    +HRD+K  N+++++   +++L D+GLA  Y   +   Y  
Sbjct: 122 IKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRG-QIKLADFGLARLYSSEESRPYTN 180

Query: 191 RVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLG 250
           +V + +++ PELL+  + Y  ++D+WS GC+L  + F K+P F  +    QL  I+++ G
Sbjct: 181 KVITLWYRPPELLLGEERYTPAIDVWSCGCILGEL-FTKKPIFQANQELAQLELISRICG 239

Query: 251 TEDLYDYIDKYNIELDPRFNDI--LGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYD 308
           +     + D   +   P FN +    ++ RK  E FV       +   ALD  D +L  D
Sbjct: 240 SPCPAVWPDVIKL---PYFNTMKPKKQYRRKLREEFV------FIPAAALDLFDYMLALD 290

Query: 309 HQSRLTAREAMEHPYFYTV 327
              R TA +A++  +   V
Sbjct: 291 PSKRCTAEQALQCEFLRDV 309


>4ZSG-A nrPDB
          Length = 347

 Score =  121 bits (303), Expect = 5e-28,   Method: Compositional matrix adjust.
 Identities = 86/307 (28%), Positives = 155/307 (50%), Gaps = 31/307 (10%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK-----PVKKKKIKREIKILENLRGG 91
           D+Y+++  +G G Y  V  A      ++V +K +          K+  RE+KIL++ +  
Sbjct: 7   DEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHD 66

Query: 92  PNIITLADIVKDPV---SRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALD 145
            NII + DI++  V         V   +  +D  Q+    Q LT   +R+++Y++L+ L 
Sbjct: 67  -NIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLK 125

Query: 146 YCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGL--------AEFYHPGQEYNVRVASRYF 197
           Y HS  ++HRD+KP N++++ E+ +L++ D+G+        AE  +   EY   VA+R++
Sbjct: 126 YMHSAQVIHRDLKPSNLLVN-ENCELKIGDFGMARGLCTSPAEHQYFMTEY---VATRWY 181

Query: 198 KGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDY 257
           + PEL++    Y  ++D+WS+GC+   M+ R++  F G +   QL  I  VLGT      
Sbjct: 182 RAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQ-LFPGKNYVHQLQLIMMVLGTPS-PAV 239

Query: 258 IDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTARE 317
           I     E    +   L       WE      ++     +AL  L ++LR++  +R++A  
Sbjct: 240 IQAVGAERVRAYIQSLPPRQPVPWETVYPGADR-----QALSLLGRMLRFEPSARISAAA 294

Query: 318 AMEHPYF 324
           A+ HP+ 
Sbjct: 295 ALRHPFL 301


>3E3P-A nrPDB
          Length = 360

 Score =  118 bits (295), Expect = 5e-27,   Method: Compositional matrix adjust.
 Identities = 87/308 (28%), Positives = 157/308 (50%), Gaps = 32/308 (10%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIK-REIKILENLR--GGPN 93
           D +Q+ R  G+G +  V   +    +  + V I K ++  + + RE++I+++L     PN
Sbjct: 23  DRFQVERMAGQGTFGTV--QLGKEKSTGMSVAIKKVIQDPRFRNRELQIMQDLAVLHHPN 80

Query: 94  IITLADIV-----KDPVSRTPALVFEHVNNTDFKQLYQTLTDY----------DIRFYMY 138
           I+ L         +D       +V E+V +T    L++   +Y           I+ +++
Sbjct: 81  IVQLQSYFYTLGERDRRDIYLNVVMEYVPDT----LHRCCRNYYRRQVAPPPILIKVFLF 136

Query: 139 EILKALDYCH--SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY 196
           ++++++   H  S+ + HRD+KPHNV+++     L+L D+G A+   P +     + SRY
Sbjct: 137 QLIRSIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKLSPSEPNVAYICSRY 196

Query: 197 FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYD 256
           ++ PEL+   Q Y  ++D+WS+GC+ A M+   EP F G ++  QL  I +VLG     +
Sbjct: 197 YRAPELIFGNQHYTTAVDIWSVGCIFAEMML-GEPIFRGDNSAGQLHEIVRVLGCPS-RE 254

Query: 257 YIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAR 316
            + K    L+P   D+   +S+      V S++    + EA D L  LL+Y  + R+   
Sbjct: 255 VLRK----LNPSHTDVDLYNSKGIPWSNVFSDHSLKDAKEAYDLLSALLQYLPEERMKPY 310

Query: 317 EAMEHPYF 324
           EA+ HPYF
Sbjct: 311 EALCHPYF 318


>4NST-A nrPDB
          Length = 351

 Score =  117 bits (293), Expect = 9e-27,   Method: Compositional matrix adjust.
 Identities = 87/329 (26%), Positives = 167/329 (50%), Gaps = 32/329 (9%)

Query: 32  EWGNQ--DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK-----IKREIKI 84
           +WG +  D + ++  +G G Y +V++A +    E V +K ++   +K+       REIKI
Sbjct: 6   DWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKI 65

Query: 85  LENLRGGPNIITLADIVKDPVSRTPA--------LVFEHVNNTDFKQLYQTLTDYD---I 133
           L  L    +++ + +IV D               LVFE++++     L   L  +    I
Sbjct: 66  LRQLIHR-SVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHI 124

Query: 134 RFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE--YNVR 191
           + +M ++++ L+YCH    +HRD+K  N+++++   +++L D+GLA  Y+  +   Y  +
Sbjct: 125 KSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSG-QIKLADFGLARLYNSEESRPYTNK 183

Query: 192 VASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGT 251
           V + +++ PELL+  + Y  ++D+WS GC+L  + F K+P F  +    QL  I+++ G+
Sbjct: 184 VITLWYRPPELLLGEERYTPAIDVWSCGCILGEL-FTKKPIFQANLELAQLELISRLCGS 242

Query: 252 EDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQS 311
                + D   +   P FN +     +K++ R +  E   + S  ALD LD +L  D   
Sbjct: 243 PCPAVWPDVIKL---PYFNTM---KPKKQYRRRLREEFSFIPSA-ALDLLDHMLTLDPSK 295

Query: 312 RLTAREAMEHPYFYTVVKDQARMGSSSMP 340
           R TA + ++  +   V  + ++M    +P
Sbjct: 296 RCTAEQTLQSDFLKDV--ELSKMAPPDLP 322


>3PG1-A nrPDB
          Length = 362

 Score =  117 bits (293), Expect = 9e-27,   Method: Compositional matrix adjust.
 Identities = 82/312 (26%), Positives = 149/312 (47%), Gaps = 29/312 (9%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAI-------------NITNNEKVVVKILKPVKKKKIKREI 82
           Q  Y + R +  G Y  V   +             N  ++ + V  +      K++ REI
Sbjct: 21  QSPYTVQRFISSGSYGAVCAGVDSEGIPVAIKRVFNTVSDGRTVNILSDSFLCKRVLREI 80

Query: 83  KILENLRGGPNIITLADIV---KDPVSRTPALVFEHVNNTDFKQLYQ----TLTDYDIRF 135
           ++L +    PNI+ L DI    ++P      LV E +  TD  Q+       ++   I++
Sbjct: 81  RLLNHFHH-PNILGLRDIFVHFEEPAMHKLYLVTE-LMRTDLAQVIHDQRIVISPQHIQY 138

Query: 136 YMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASR 195
           +MY IL  L   H  G++HRD+ P N+++  ++  + + D+ LA            V  R
Sbjct: 139 FMYHILLGLHVLHEAGVVHRDLHPGNILLA-DNNDITICDFNLAREDTADANKTHYVTHR 197

Query: 196 YFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLY 255
           +++ PEL++ ++ +   +DMWS GC++A M F ++  F G   Y+QL +I +V+GT  + 
Sbjct: 198 WYRAPELVMQFKGFTKLVDMWSAGCVMAEM-FNRKALFRGSTFYNQLNKIVEVVGTPKIE 256

Query: 256 DYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTA 315
           D +   +        + L     + W   V + +     P ALD + K+L ++ Q R++ 
Sbjct: 257 DVVMFSSPSARDYLRNSLSNVPARAWTAVVPTAD-----PVALDLIAKMLEFNPQRRIST 311

Query: 316 REAMEHPYFYTV 327
            +A+ HPYF ++
Sbjct: 312 EQALRHPYFESL 323


>4BBM-A nrPDB
          Length = 331

 Score =  117 bits (292), Expect = 1e-26,   Method: Compositional matrix adjust.
 Identities = 75/228 (32%), Positives = 127/228 (55%), Gaps = 14/228 (6%)

Query: 33  WGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVK-ILKPVKKKKIK----REIKILEN 87
           + + + Y+ +  +G G Y  V +  N      V +K  L+    K +K    REIK+L+ 
Sbjct: 21  FQSMEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQ 80

Query: 88  LRGGPNIITLADIVKDPVSRTPALVFEHVNNT--DFKQLYQTLTDYDI-RFYMYEILKAL 144
           LR   N++ L ++ K    +   LVFE V++T  D  +L+    DY + + Y+++I+  +
Sbjct: 81  LRH-ENLVNLLEVCKK--KKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGI 137

Query: 145 DYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE-FYHPGQEYNVRVASRYFKGPELL 203
            +CHS  I+HRD+KP N+++  +   ++L D+G A     PG+ Y+  VA+R+++ PELL
Sbjct: 138 GFCHSHNIIHRDIKPENILVS-QSGVVKLCDFGFARTLAAPGEVYDDEVATRWYRAPELL 196

Query: 204 VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGT 251
           V    Y  ++D+W++GC++  M F  EP F G  + DQL  I   LG 
Sbjct: 197 VGDVKYGKAVDVWAIGCLVTEM-FMGEPLFPGDSDIDQLYHIMMCLGN 243


>4BGQ-A nrPDB
          Length = 304

 Score =  116 bits (290), Expect = 2e-26,   Method: Compositional matrix adjust.
 Identities = 90/306 (29%), Positives = 151/306 (49%), Gaps = 33/306 (10%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK-----KKKIKREIKILENLRGG 91
           + ++++  +G G Y  V +  +   +E V +K  K  +     K+   RE+K+L  L+  
Sbjct: 12  NKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ- 70

Query: 92  PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYCH 148
            NI+ L +  +        LVFE+V     + L +    +    ++ Y+Y+++KA+ +CH
Sbjct: 71  ENIVELKEAFRR--RGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCH 128

Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ--EYNVRVASRYFKGPELLVDY 206
              I+HRD+KP N++I H +  L+L D+G A     G    Y+  VA+R+++ PELL+  
Sbjct: 129 KNDIVHRDIKPENLLISH-NDVLKLCDFGFARNLSEGNNANYDEEVATRWYRSPELLLGA 187

Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLG---TEDLYDYIDKYNI 263
             Y  S+DMWS+GC+L  +    +P F G    DQL  I KVLG   +E +  +      
Sbjct: 188 P-YGKSVDMWSVGCILGEL-SDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYS---- 241

Query: 264 ELDPRFNDI---LGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAME 320
             +PRF+ +      H +    R++   N  L     LD +  LL+ D   R    + + 
Sbjct: 242 --NPRFHGLRFPAVNHPQSLERRYLGILNSVL-----LDLMKNLLKLDPADRYLTEQCLN 294

Query: 321 HPYFYT 326
           HP F T
Sbjct: 295 HPTFQT 300


>2I6L-A nrPDB
          Length = 320

 Score =  114 bits (284), Expect = 9e-26,   Method: Compositional matrix adjust.
 Identities = 86/308 (27%), Positives = 147/308 (47%), Gaps = 33/308 (10%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVK---ILKPVKKKKIKREIKILENLRG----- 90
           Y  ++ LG G    VF A++   +++V +K   +  P   K   REIKI+  L       
Sbjct: 13  YMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKHALREIKIIRRLDHDNIVK 72

Query: 91  -----GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT--LTDYDIRFYMYEILKA 143
                GP+   L D V          + +    TD   + +   L +   R +MY++L+ 
Sbjct: 73  VFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLLRG 132

Query: 144 LDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVA----SRYFKG 199
           L Y HS  ++HRD+KP N+ I+ E   L++ D+GLA    P   +   ++    +++++ 
Sbjct: 133 LKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWYRS 192

Query: 200 PELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAK---VLGTEDLYD 256
           P LL+    Y  ++DMW+ GC+ A M+  K  F   H+  +Q+  I +   V+  ED  +
Sbjct: 193 PRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHE-LEQMQLILESIPVVHEEDRQE 251

Query: 257 YIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAR 316
            +    + +    ND+   H  K   + +       +S EA+DFL+++L +    RLTA 
Sbjct: 252 LLSVIPVYIR---NDMTEPH--KPLTQLLPG-----ISREAVDFLEQILTFSPMDRLTAE 301

Query: 317 EAMEHPYF 324
           EA+ HPY 
Sbjct: 302 EALSHPYM 309


>3MIA-A nrPDB
          Length = 351

 Score =  114 bits (284), Expect = 1e-25,   Method: Compositional matrix adjust.
 Identities = 92/309 (29%), Positives = 159/309 (51%), Gaps = 31/309 (10%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVK-ILKPVKKKKIK----REIKILENLRGGPN 93
           Y+ + K+G+G + EVF+A +    +KV +K +L   +K+       REIKIL+ L+   N
Sbjct: 19  YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH-EN 77

Query: 94  IITLADIVK---DPVSRTPA---LVFEHVNNTDFKQLYQTLTDY---DIRFYMYEILKAL 144
           ++ L +I +    P +R      LVF+   +     L   L  +   +I+  M  +L  L
Sbjct: 78  VVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGL 137

Query: 145 DYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ-----EYNVRVASRYFKG 199
            Y H   I+HRD+K  NV+I  +   L+L D+GLA  +   +      Y  RV + +++ 
Sbjct: 138 YYIHRNKILHRDMKAANVLITRDG-VLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRP 196

Query: 200 PELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLG--TEDLYDY 257
           PELL+  + Y   +D+W  GC++A M + + P   G+    QL  I+++ G  T +++  
Sbjct: 197 PELLLGERDYGPPIDLWGAGCIMAEM-WTRSPIMQGNTEQHQLALISQLCGSITPEVWPN 255

Query: 258 IDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTARE 317
           +D Y  EL  +   + G+  RK  +R       ++  P ALD +DKLL  D   R+ + +
Sbjct: 256 VDNY--ELYEKLELVKGQ-KRKVKDRL----KAYVRDPYALDLIDKLLVLDPAQRIDSDD 308

Query: 318 AMEHPYFYT 326
           A+ H +F++
Sbjct: 309 ALNHDFFWS 317


>3NIE-A nrPDB
          Length = 429

 Score =  110 bits (274), Expect = 2e-24,   Method: Compositional matrix adjust.
 Identities = 94/367 (25%), Positives = 165/367 (44%), Gaps = 77/367 (20%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP-----VKKKKIKREIKILENLRGG 91
           D+Y++   +GRG Y  V+ A +   N+ V +K +       +  K+I REI IL  L+  
Sbjct: 28  DNYEIKHLIGRGSYGYVYLAYDKNANKNVAIKKVNRMFEDLIDCKRILREITILNRLKSD 87

Query: 92  PNIITLADIV--KDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDY 146
             II L D++  +D +      +   + ++D K+L++T   LT+  ++  +Y +L    +
Sbjct: 88  -YIIRLHDLIIPEDLLKFDELYIVLEIADSDLKKLFKTPIFLTEQHVKTILYNLLLGEKF 146

Query: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH-------------------PG-- 185
            H  GI+HRD+KP N +++ +   +++ D+GLA   +                   PG  
Sbjct: 147 IHESGIIHRDLKPANCLLNQDC-SVKICDFGLARTINSDKDIHIVNDLEEKEENEEPGPH 205

Query: 186 -----QEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMI----------FRKE 230
                ++    V +R+++ PEL++  + Y  S+D+WS GC+ A ++            + 
Sbjct: 206 NKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDIWSTGCIFAELLNMMKSHINNPTNRF 265

Query: 231 PFF-----------------HGHDNYDQLVRIAKVLGT---EDLYDYIDKYNIELDPRFN 270
           P F                 H   N DQL  I  V+GT   EDL     +  I+    F 
Sbjct: 266 PLFPGSSCFPLSPDHNSKKVHEKSNRDQLNIIFNVIGTPPEEDLKCITKQEVIKYIKLFP 325

Query: 271 DILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKD 330
              G    K++           +S E +D L+ +LR++ Q R+T  +A+ HPY   V K+
Sbjct: 326 TRDGIDLSKKYSS---------ISKEGIDLLESMLRFNAQKRITIDKALSHPYLKDVRKE 376

Query: 331 QARMGSS 337
                S+
Sbjct: 377 NLENFST 383


>3RP9-A nrPDB
          Length = 458

 Score =  109 bits (273), Expect = 2e-24,   Method: Compositional matrix adjust.
 Identities = 99/365 (27%), Positives = 161/365 (44%), Gaps = 78/365 (21%)

Query: 32  EWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVK-ILKP----VKKKKIKREIKILE 86
           +W   D Y++   +G G Y  V EA +      V +K IL+     +  K+I REI IL 
Sbjct: 48  DWQIPDRYEIRHLIGTGSYGHVCEAYDKLEKRVVAIKKILRVFEDLIDCKRILREIAILN 107

Query: 87  NLRGGPNIITLADIV--KDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEIL 141
            L    +++ + DIV  KD        V   + ++DFK+L++T   LT+  I+  +Y +L
Sbjct: 108 RLNHD-HVVKVLDIVIPKDVEKFDELYVVLEIADSDFKKLFRTPVYLTELHIKTLLYNLL 166

Query: 142 KALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE--------------------- 180
             + Y HS GI+HRD+KP N +++ +   +++ D+GLA                      
Sbjct: 167 VGVKYVHSAGILHRDLKPANCLVNQDC-SVKVCDFGLARTVDYPENGNSQLPISPREDDM 225

Query: 181 ----FYHP---GQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMI------- 226
               F H     ++    V +R+++ PEL++  + Y  ++D+WS+GC+ A ++       
Sbjct: 226 NLVTFPHTKNLKRQLTGHVVTRWYRAPELILLQENYTEAIDVWSIGCIFAELLNMIKENV 285

Query: 227 ---------------FRKEP--------FFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNI 263
                          F   P         FH   N DQL  I  +LGT    D I+    
Sbjct: 286 AYHADRGPLFPGSSCFPLSPDQKAGNDFKFHTRGNRDQLNVIFNILGTPSEED-IEALEK 344

Query: 264 ELDPRFNDIL-GRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHP 322
           E   R+  I   R      ERF  S      S +A+  L ++L ++   R+T  E + HP
Sbjct: 345 EDAKRYIRIFPKREGTDLAERFPAS------SADAIHLLKRMLVFNPNKRITINECLAHP 398

Query: 323 YFYTV 327
           +F  V
Sbjct: 399 FFKEV 403


>5Y86-A nrPDB
          Length = 588

 Score =  108 bits (269), Expect = 5e-24,   Method: Compositional matrix adjust.
 Identities = 98/400 (24%), Positives = 185/400 (46%), Gaps = 71/400 (17%)

Query: 18  HRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK-- 75
           H PR++  Y            Y++++ +G+G + +V    +    + V +K+++  K+  
Sbjct: 199 HVPRDHLAYR-----------YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFH 247

Query: 76  KKIKREIKILENLR-----GGPNIITLAD--IVKDPVSRTPALVFEHVNNTDFKQLYQTL 128
           ++   EI+ILE+L+     G  N+I + +    ++ V     L+   +     K  +Q  
Sbjct: 248 RQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGF 307

Query: 129 TDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHR-KLRLIDWGLAEFYHPGQE 187
           +   +R +   IL++LD  H   I+H D+KP N+++ H  R   ++ID+G + F +  Q+
Sbjct: 308 SVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEY--QK 365

Query: 188 YNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAK 247
               + SR+++ PE+++  + Y   +D+WS GC+LA ++   +P F G D  DQL  + +
Sbjct: 366 LYTYIQSRFYRAPEIILGSR-YSTPIDIWSFGCILAELL-TGQPLFPGEDEGDQLACMME 423

Query: 248 VLG---------TEDLYDYIDKYNI--------ELDPRFNDILGRHSR---------KRW 281
           +LG         ++    +I+   I        + D R   + GR  R         K W
Sbjct: 424 LLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDW 483

Query: 282 ERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPG 341
              +   + +L     ++FL + L +D  +RLT  +A+ HP+            S S+P 
Sbjct: 484 GTALKGCDDYLF----IEFLKRCLHWDPSARLTPAQALRHPWI-----------SKSVP- 527

Query: 342 GSTPVSSANMMSGISSVPTPSPLGPLAGS--PVIAAANPL 379
              P+++ + +SG   V   S    L     PV+  AN L
Sbjct: 528 --RPLTTIDKVSGKRVVNPASAFQGLGSKLPPVVGIANKL 565


>4O2Z-A nrPDB
          Length = 377

 Score =  107 bits (266), Expect = 1e-23,   Method: Compositional matrix adjust.
 Identities = 88/307 (28%), Positives = 147/307 (47%), Gaps = 40/307 (13%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK-----KKIKREIKIL-----ENL 88
           Y L++ LG G Y      ++    EKV +K  + V +     K++ REI ++     ENL
Sbjct: 47  YTLLKILGMGAYGIACSCLDGDTGEKVSIKKCRDVFRDVEDGKRVLREIDMMRFFHHENL 106

Query: 89  RGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALD 145
               NI  L  + ++  S     V   + + D   +    Q L +  +++++Y+IL+ L 
Sbjct: 107 LNVVNI--LPPLKREYHSFEDVYVVTPLMDVDMNVVLRSRQVLEESHMQYFVYQILRGLK 164

Query: 146 YCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH-PGQEYNVRVASRYFKGPELLV 204
           Y HS  + HRD+KP N ++ +   +L++ID+GL+     P  E    V +R+++ PELL+
Sbjct: 165 YLHSANVAHRDLKPAN-LVTNISCELKIIDFGLSRSVDVPYSELTDYVITRWYRPPELLL 223

Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIE 264
           +   Y  ++D+WS+GC+ A M  RK P F G +  DQL  IA+ +G              
Sbjct: 224 ENTNYSTAVDIWSVGCIFAEMYNRK-PVFPGRNTMDQLRMIAQHIGK------------- 269

Query: 265 LDPRFNDILGRHSRKRWERFVH-SENQHLVSP------EALDFLDKLLRYDHQSRLTARE 317
             P  + +  R + ++       S N   + P      E +DFL K+   D   R TA +
Sbjct: 270 --PPASIVEHREALEKLNELPDGSLNIPKLVPGLAGNTEGIDFLSKMWTLDPSKRPTAAD 327

Query: 318 AMEHPYF 324
            + HPY 
Sbjct: 328 MLAHPYL 334


>2W96-B nrPDB
          Length = 306

 Score =  105 bits (263), Expect = 2e-23,   Method: Compositional matrix adjust.
 Identities = 88/307 (28%), Positives = 148/307 (48%), Gaps = 39/307 (12%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILK-PVKKKKIK----REIKILENLRG--G 91
           Y+ V ++G G Y  V++A +  +   V +K ++ P  ++ +     RE+ +L  L     
Sbjct: 6   YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGLPISTVREVALLRRLEAFEH 65

Query: 92  PNIITLADIVKDPVSRTP-----ALVFEHVNNTDFKQLYQT----LTDYDIRFYMYEILK 142
           PN++ L D+     SRT       LVFEHV+      L +     L    I+  M + L+
Sbjct: 66  PNVVRLMDVCA--TSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLR 123

Query: 143 ALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPEL 202
            LD+ H+  I+HRD+KP N+++      ++L D+GLA  Y      +  V + +++ PE+
Sbjct: 124 GLDFLHANCIVHRDLKPENILVT-SGGTVKLADFGLARIYSYQMALDPVVVTLWYRAPEV 182

Query: 203 LVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYN 262
           L+    Y   +DMWS+GC+ A M FR++P F G+   DQL +I  ++G     D+     
Sbjct: 183 LLQ-STYATPVDMWSVGCIFAEM-FRRKPLFCGNSEADQLGKIFDLIGLPPEDDW----- 235

Query: 263 IELDPRFNDILGRHSRKRWERFVHSENQHLVSPE----ALDFLDKLLRYDHQSRLTAREA 318
               PR   +       R  R V S     V PE        L ++L ++   R++A  A
Sbjct: 236 ----PRDVSLPRGAFPPRGPRPVQS-----VVPEMEESGAQLLLEMLTFNPHKRISAFRA 286

Query: 319 MEHPYFY 325
           ++H Y +
Sbjct: 287 LQHSYLH 293


>3ZDU-A nrPDB
          Length = 325

 Score =  104 bits (259), Expect = 7e-23,   Method: Compositional matrix adjust.
 Identities = 80/300 (26%), Positives = 147/300 (49%), Gaps = 31/300 (10%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIK----REIKILENLRGGPNI 94
           Y+ + K+G G Y  V +  +    + V +KI     ++ +     REIK L+      N+
Sbjct: 5   YETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQFHH-ENL 63

Query: 95  ITLADIVKDPVSRTPALVFEHVNNTDFKQL---YQTLTDYDIRFYMYEILKALDYCHSMG 151
           + L ++ +    +   LVFE +++T   +L      L    +R Y+++IL+A+DY HS  
Sbjct: 64  VNLIEVFRQ--KKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSNN 121

Query: 152 IMHRDVKPHNVMIDHEHRKLRLIDWGLAE-FYHPGQEYNVRVASRYFKGPELLVDYQMYD 210
           I+HRD+KP N+++  +    +L D+G A     PG  Y+  VA+R+++ PEL++    Y 
Sbjct: 122 IIHRDIKPENILVS-QSGITKLCDFGFARTLAAPGDIYDDEVATRWYRAPELVLKDTSYG 180

Query: 211 YSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFN 270
             +D+W+LGCM+  M     P+     + D L +I  VL   +L  ++        P F 
Sbjct: 181 KPVDIWALGCMIIEMA-TGNPYLPSSSDLDLLHKI--VLKVGNLSPHLQNI-FSKSPIFA 236

Query: 271 DIL------GRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324
            ++       +++RK++ +     N  L      D +   L+ D   R+++ + + H YF
Sbjct: 237 GVVLPQVQHPKNARKKYPKL----NGLLA-----DIVHACLQIDPADRISSSDLLHHEYF 287


>5ZTN-A nrPDB
          Length = 429

 Score =  103 bits (257), Expect = 1e-22,   Method: Compositional matrix adjust.
 Identities = 81/318 (25%), Positives = 158/318 (49%), Gaps = 36/318 (11%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK--KKIKREIKILENLR-----GG 91
           Y++++ +G+G + +V +A +   ++ V +K+++  K+  ++   EI+ILE+LR       
Sbjct: 99  YEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNT 158

Query: 92  PNIITLAD--IVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHS 149
            N+I + +    ++ +  T  L+  ++     K  +Q  +   +R + + IL+ LD  H 
Sbjct: 159 MNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHK 218

Query: 150 MGIMHRDVKPHNVMIDHEHRK-LRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQM 208
             I+H D+KP N+++  + R  +++ID+G + + H  Q     + SR+++ PE+++  + 
Sbjct: 219 NRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEH--QRVYTYIQSRFYRAPEVILGAR- 275

Query: 209 YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLG--TEDLYDYIDKYNIELD 266
           Y   +DMWSLGC+LA ++    P   G D  DQL  + ++LG  ++ L D   +    + 
Sbjct: 276 YGMPIDMWSLGCILAELL-TGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVS 334

Query: 267 ----PRFNDIL-----------GRHSRKRWERFVHSEN-----QHLVSPEALDFLDKLLR 306
               PR+  +            GR  R +      S       +    P  LDFL + L 
Sbjct: 335 SKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLE 394

Query: 307 YDHQSRLTAREAMEHPYF 324
           +D   R+T  +A+ HP+ 
Sbjct: 395 WDPAVRMTPGQALRHPWL 412


>3MN3-A nrPDB
          Length = 271

 Score =  103 bits (256), Expect = 2e-22,   Method: Compositional matrix adjust.
 Identities = 64/203 (31%), Positives = 109/203 (53%), Gaps = 12/203 (5%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL------KPVKKKKIKREIKILENLRGG 91
           +YQ+V+ LG G + +V  A + T  +KV +KI+      K   + +I+REI  L  LR  
Sbjct: 5   NYQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRH- 63

Query: 92  PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ--TLTDYDIRFYMYEILKALDYCHS 149
           P+II L D++K        +V E+  N  F  + Q   +++ + R +  +I+ A++YCH 
Sbjct: 64  PHIIKLYDVIKS--KDEIIMVIEYAGNELFDYIVQRDKMSEQEARRFFQQIISAVEYCHR 121

Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMY 209
             I+HRD+KP N+++D EH  +++ D+GL+     G        S  +  PE++      
Sbjct: 122 HKIVHRDLKPENLLLD-EHLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKLYA 180

Query: 210 DYSLDMWSLGCMLASMIFRKEPF 232
              +D+WS G +L  M+ R+ PF
Sbjct: 181 GPEVDVWSCGVILYVMLCRRLPF 203


>3E7O-A nrPDB
          Length = 360

 Score =  102 bits (253), Expect = 3e-22,   Method: Compositional matrix adjust.
 Identities = 79/301 (26%), Positives = 146/301 (48%), Gaps = 20/301 (6%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKIL-KPVKK----KKIKREIKILENLRGGPN 93
           YQ ++ +G G    V  A +      V VK L +P +     K+  RE+ +L+ +    N
Sbjct: 24  YQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCV-NHKN 82

Query: 94  IITLADIVKDPVS----RTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHS 149
           II+L ++     +    +   LV E ++    + ++  L    + + +Y++L  + + HS
Sbjct: 83  IISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHS 142

Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMY 209
            GI+HRD+KP N+++  +   L+++D+GLA            V +RY++ PE+++    Y
Sbjct: 143 AGIIHRDLKPSNIVVKSDC-TLKILDFGLARTASTNFMMTPYVVTRYYRAPEVILGMG-Y 200

Query: 210 DYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTED------LYDYIDKYNI 263
             ++D+WS+GC++  ++ +    F G D+ DQ  ++ + LGT        L   +  Y +
Sbjct: 201 KENVDIWSVGCIMGELV-KGSVIFQGTDHIDQWNKVIEQLGTPSAEFMAALQPTVRNY-V 258

Query: 264 ELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323
           E  P +  I        W     SE   + + +A D L K+L  D   R++  EA+ HPY
Sbjct: 259 ENRPAYPGIAFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPY 318

Query: 324 F 324
            
Sbjct: 319 I 319


>2X4F-A nrPDB
          Length = 373

 Score =  101 bits (251), Expect = 6e-22,   Method: Compositional matrix adjust.
 Identities = 86/332 (25%), Positives = 154/332 (46%), Gaps = 49/332 (14%)

Query: 4   PVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRK---LGRGKYSEVFEAINIT 60
           PV S+      V+   P   +D+     + G  + +  V K   LG G++ +V +     
Sbjct: 53  PVKSKRTSALAVDIPAPPAPFDHRIVTAKQGAVNSFYTVSKTEILGGGRFGQVHKCEETA 112

Query: 61  NNEKVVVKILKP---VKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVN 117
              K+  KI+K      K+++K EI ++  L    N+I L D  +        LV E+V+
Sbjct: 113 TGLKLAAKIIKTRGMKDKEEVKNEISVMNQLDHA-NLIQLYDAFES--KNDIVLVMEYVD 169

Query: 118 NTD-FKQLYQ---TLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVM-IDHEHRKLR 172
             + F ++      LT+ D   +M +I + + + H M I+H D+KP N++ ++ + ++++
Sbjct: 170 GGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQMYILHLDLKPENILCVNRDAKQIK 229

Query: 173 LIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPF 232
           +ID+GLA  Y P ++  V   +  F  PE +V+Y    +  DMWS+G +   ++    PF
Sbjct: 230 IIDFGLARRYKPREKLKVNFGTPEFLAPE-VVNYDFVSFPTDMWSVGVIAYMLLSGLSPF 288

Query: 233 FHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHL 292
              +D        A+ L                    N+IL      RW+  +  E    
Sbjct: 289 LGDND--------AETL--------------------NNILA----CRWD--LEDEEFQD 314

Query: 293 VSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324
           +S EA +F+ KLL  +   R++A EA++HP+ 
Sbjct: 315 ISEEAKEFISKLLIKEKSWRISASEALKHPWL 346


>5JN2-A nrPDB
          Length = 525

 Score =  100 bits (249), Expect = 1e-21,   Method: Compositional matrix adjust.
 Identities = 81/311 (26%), Positives = 147/311 (47%), Gaps = 60/311 (19%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL--KPVKKKKIK----REIKILENLRG 90
           D Y+  R LG+G + EV    +    ++  VK++  + VK+K  K    RE+++L+ L  
Sbjct: 67  DRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQL-D 125

Query: 91  GPNIITLADIVKDP--------VSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILK 142
            PNI+ L +  +D         V     L  E ++   F ++       D    + ++L 
Sbjct: 126 HPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEV-------DAARIIRQVLS 178

Query: 143 ALDYCHSMGIMHRDVKPHNVMIDHEHR--KLRLIDWGLAEFYHPGQEYNVRVASRYFKGP 200
            + Y H   I+HRD+KP N++++ + +   +R+ID+GL+  +   ++   ++ + Y+  P
Sbjct: 179 GITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAP 238

Query: 201 ELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDK 260
           E+L  +  YD   D+WS G +L  ++    P F+G + YD L ++ K            K
Sbjct: 239 EVL--HGTYDEKCDVWSTGVILY-ILLSGCPPFNGANEYDILKKVEK-----------GK 284

Query: 261 YNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAME 320
           Y  EL              +W++         VS  A D + K+L Y    R++AR+A++
Sbjct: 285 YTFEL-------------PQWKK---------VSESAKDLIRKMLTYVPSMRISARDALD 322

Query: 321 HPYFYTVVKDQ 331
           H +  T  K+Q
Sbjct: 323 HEWIQTYTKEQ 333


>3N9X-A nrPDB
          Length = 432

 Score = 99.8 bits (247), Expect = 2e-21,   Method: Compositional matrix adjust.
 Identities = 89/369 (24%), Positives = 165/369 (44%), Gaps = 84/369 (22%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP-----VKKKKIKREIKILENLRGG 91
           D+Y +   +GRG Y  V+ A +    + V +K +       +  K+I REI IL  L+  
Sbjct: 26  DNYIIKHLIGRGSYGYVYLAYDKNTEKNVAIKKVNRMFEDLIDCKRILREITILNRLKSD 85

Query: 92  PNIITLADIV--KDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDY 146
             II L D++   D +      +   + ++D K+L++T   LT+  I+  +Y +L   ++
Sbjct: 86  -YIIRLYDLIIPDDLLKFDELYIVLEIADSDLKKLFKTPIFLTEEHIKTILYNLLLGENF 144

Query: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNV---------------- 190
            H  GI+HRD+KP N +++ +   +++ D+GLA   +  ++ N+                
Sbjct: 145 IHESGIIHRDLKPANCLLNQDC-SVKVCDFGLARTINSEKDTNIVNDLEENEEPGPHNKN 203

Query: 191 -------RVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMI----------FRKEPFF 233
                   V +R+++ PEL++  + Y  S+D+WS GC+ A ++            + P F
Sbjct: 204 LKKQLTSHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAELLNMLQSHINDPTNRFPLF 263

Query: 234 -----------------HGHDNYDQLVRIAKVLGT--EDLYDYIDKYNIELDPRFNDILG 274
                            H   N DQL  I  ++GT  ED    I+K  +           
Sbjct: 264 PGSSCFPLSPDRNSKKVHEKSNRDQLNIIFNIIGTPTEDDLKNINKPEV----------- 312

Query: 275 RHSRKRWERFVHSENQHL------VSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVV 328
               K  + F H +  +L      +S + ++ L+ +L+++   R+T  +A++HPY   V 
Sbjct: 313 ---IKYIKLFPHRKPINLKQKYPSISDDGINLLESMLKFNPNKRITIDQALDHPYLKDVR 369

Query: 329 KDQARMGSS 337
           K +    S+
Sbjct: 370 KKKLENFST 378


>1JNK-A nrPDB
          Length = 423

 Score = 99.0 bits (245), Expect = 3e-21,   Method: Compositional matrix adjust.
 Identities = 79/311 (25%), Positives = 147/311 (47%), Gaps = 40/311 (12%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKIL-KPVKK----KKIKREIKILENLRGGPN 93
           YQ ++ +G G    V  A +   +  V +K L +P +     K+  RE+ +L       N
Sbjct: 64  YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYREL-VLMKCVNHKN 122

Query: 94  IITLADIVKDPVSRTPALVFEHVNNT---------DFKQLYQTLTDYD-IRFYMYEILKA 143
           II+L ++       TP    E   +          +  Q+ Q   D++ + + +Y++L  
Sbjct: 123 IISLLNVF------TPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCG 176

Query: 144 LDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELL 203
           + + HS GI+HRD+KP N+++  +   L+++D+GLA            V +RY++ PE++
Sbjct: 177 IKHLHSAGIIHRDLKPSNIVVKSDC-TLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVI 235

Query: 204 VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNI 263
           +    Y  ++D+WS+GC++  M+ R +  F G D  DQ  ++ + LGT        ++  
Sbjct: 236 LGMG-YKENVDIWSVGCIMGEMV-RHKILFPGRDYIDQWNKVIEQLGTP-----CPEFMK 288

Query: 264 ELDPRFNDILGRHSRKRWERF----------VHSENQHLVSPEALDFLDKLLRYDHQSRL 313
           +L P   + +    +     F            SE+  L + +A D L K+L  D   R+
Sbjct: 289 KLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRI 348

Query: 314 TAREAMEHPYF 324
           +  +A++HPY 
Sbjct: 349 SVDDALQHPYI 359


>3MA6-A nrPDB
          Length = 298

 Score = 98.6 bits (244), Expect = 4e-21,   Method: Compositional matrix adjust.
 Identities = 81/311 (26%), Positives = 147/311 (47%), Gaps = 60/311 (19%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL--KPVKKKKIK----REIKILENLRG 90
           D Y+  R LG+G + EV    +    ++  VK++  + VK+K  K    RE+++L+ L  
Sbjct: 32  DRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQL-D 90

Query: 91  GPNIITLADIVKDP--------VSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILK 142
            PNI+ L +  +D         V     L  E ++   F ++       D    + ++L 
Sbjct: 91  HPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEV-------DAARIIRQVLS 143

Query: 143 ALDYCHSMGIMHRDVKPHNVMIDHEHR--KLRLIDWGLAEFYHPGQEYNVRVASRYFKGP 200
            + Y H   I+HRD+KP N++++ + +   +R+ID+GL+  +   ++   ++ + Y+  P
Sbjct: 144 GITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAP 203

Query: 201 ELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDK 260
           E+L  +  YD   D+WS G +L  ++    P F+G + YD L ++ K            K
Sbjct: 204 EVL--HGTYDEKCDVWSTGVILY-ILLSGCPPFNGANEYDILKKVEK-----------GK 249

Query: 261 YNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAME 320
           Y  EL              +W++         VS  A D + K+L Y    R++AR+A++
Sbjct: 250 YTFELP-------------QWKK---------VSESAKDLIRKMLTYVPSMRISARDALD 287

Query: 321 HPYFYTVVKDQ 331
           H +  T  K+Q
Sbjct: 288 HEWIQTYTKEQ 298


>4NIF-A nrPDB
          Length = 333

 Score = 98.2 bits (243), Expect = 5e-21,   Method: Compositional matrix adjust.
 Identities = 84/296 (28%), Positives = 134/296 (45%), Gaps = 46/296 (15%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIIT 96
           D Y +   +G G YSE    ++   N +  VK++   K+     EI+IL      PNIIT
Sbjct: 8   DGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDP-SEEIEILLRYGQHPNIIT 66

Query: 97  LADIVKDPVSRTPALVFEHVNNTDF--KQLYQTL-TDYDIRFYMYEILKALDYCHSMGIM 153
           L D+  D   +   LV E +   +   K L Q   ++ +  F ++ I K ++Y HS G++
Sbjct: 67  LKDVYDD--GKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVV 124

Query: 154 HRDVKPHNVMIDHEH---RKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLVDYQ 207
           HRD+KP N++   E      LR+ D+G A+      E  + +   Y   F  PE+L   Q
Sbjct: 125 HRDLKPSNILYVDESGNPECLRICDFGFAKQLRA--ENGLLMTPCYTANFVAPEVL-KRQ 181

Query: 208 MYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDP 267
            YD   D+WSLG +L +M+    PF +G  +  +                          
Sbjct: 182 GYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPE-------------------------- 215

Query: 268 RFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323
              +IL R    ++   +   N + VS  A D + K+L  D   RLTA++ ++HP+
Sbjct: 216 ---EILTRIGSGKFT--LSGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPW 266


>4CRL-A nrPDB
          Length = 406

 Score = 98.2 bits (243), Expect = 6e-21,   Method: Compositional matrix adjust.
 Identities = 83/316 (26%), Positives = 150/316 (47%), Gaps = 41/316 (12%)

Query: 44  KLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIK----REIKILENLRGGPNIITLAD 99
           K+GRG Y  V++A      +      LK ++   I     REI +L  L+  PN+I+L  
Sbjct: 29  KVGRGTYGHVYKAKRKDGKDDKDYA-LKQIEGTGISMSACREIALLRELKH-PNVISLQK 86

Query: 100 IVKDPVSRTPALVFEHVNN-----TDFKQLYQT------LTDYDIRFYMYEILKALDYCH 148
           +      R   L+F++  +       F +  +       L    ++  +Y+IL  + Y H
Sbjct: 87  VFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHYLH 146

Query: 149 SMGIMHRDVKPHNVMI---DHEHRKLRLIDWGLAEFYH----PGQEYNVRVASRYFKGPE 201
           +  ++HRD+KP N+++     E  ++++ D G A  ++    P  + +  V + +++ PE
Sbjct: 147 ANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPE 206

Query: 202 LLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHD---------NYDQLVRIAKVLGTE 252
           LL+  + Y  ++D+W++GC+ A ++   EP FH            ++DQL RI  V+G  
Sbjct: 207 LLLGARHYTKAIDIWAIGCIFAELL-TSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFP 265

Query: 253 DLYDYIDKYNIELDPRFNDILGRHSRKRWER--FVHSENQHLVSPE--ALDFLDKLLRYD 308
              D+ D   I+  P  + ++    R  +     +    +H V P+  A   L KLL  D
Sbjct: 266 ADKDWED---IKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMD 322

Query: 309 HQSRLTAREAMEHPYF 324
              R+T+ +AM+ PYF
Sbjct: 323 PIKRITSEQAMQDPYF 338


>3FI2-A nrPDB
          Length = 353

 Score = 97.4 bits (241), Expect = 8e-21,   Method: Compositional matrix adjust.
 Identities = 79/311 (25%), Positives = 147/311 (47%), Gaps = 40/311 (12%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKIL-KPVKK----KKIKREIKILENLRGGPN 93
           YQ ++ +G G    V  A +   +  V +K L +P +     K+  RE+ +L       N
Sbjct: 26  YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYREL-VLMKCVNHKN 84

Query: 94  IITLADIVKDPVSRTPALVFEHVNNT---------DFKQLYQTLTDYD-IRFYMYEILKA 143
           II+L ++       TP    E   +          +  Q+ Q   D++ + + +Y++L  
Sbjct: 85  IISLLNVF------TPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCG 138

Query: 144 LDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELL 203
           + + HS GI+HRD+KP N+++  +   L+++D+GLA            V +RY++ PE++
Sbjct: 139 IKHLHSAGIIHRDLKPSNIVVKSDC-TLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVI 197

Query: 204 VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNI 263
           +    Y  ++D+WS+GC++  M+ R +  F G D  DQ  ++ + LGT        ++  
Sbjct: 198 LGMG-YKENVDIWSVGCIMGEMV-RHKILFPGRDYIDQWNKVIEQLGTP-----CPEFMK 250

Query: 264 ELDPRFNDILGRHSRKRWERF----------VHSENQHLVSPEALDFLDKLLRYDHQSRL 313
           +L P   + +    +     F            SE+  L + +A D L K+L  D   R+
Sbjct: 251 KLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRI 310

Query: 314 TAREAMEHPYF 324
           +  +A++HPY 
Sbjct: 311 SVDDALQHPYI 321


>2XS0-A nrPDB
          Length = 386

 Score = 97.4 bits (241), Expect = 8e-21,   Method: Compositional matrix adjust.
 Identities = 81/304 (26%), Positives = 149/304 (49%), Gaps = 26/304 (8%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKIL-KPVKK----KKIKREIKILENLRGGPN 93
           YQ ++ +G G    V  A +      V +K L +P +     K+  RE+ +L       N
Sbjct: 28  YQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYREL-VLMKCVNHKN 86

Query: 94  IITLADIVKDPVSRTP---ALVFEHVNNTDFKQLYQTLTDYD-IRFYMYEILKALDYCHS 149
           II L ++     S        +   + + +  Q+ Q   D++ + + +Y++L  + + HS
Sbjct: 87  IIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHS 146

Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMY 209
            GI+HRD+KP N+++  +   L+++D+GLA            V +RY++ PE+++    Y
Sbjct: 147 AGIIHRDLKPSNIVVKSDC-TLKILDFGLARTAGTSFMMVPFVVTRYYRAPEVILGMG-Y 204

Query: 210 DYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGT------EDLYDYIDKYNI 263
             ++D+WS+GC++  MI +    F G D+ DQ  ++ + LGT      + L   +  Y +
Sbjct: 205 KENVDIWSVGCIMGEMI-KGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQPTVRTY-V 262

Query: 264 ELDPRFNDILGRHSRKRWERFVH---SENQHLVSPEALDFLDKLLRYDHQSRLTAREAME 320
           E  P++    G    K +   +    SE+  L + +A D L K+L  D   R++  EA++
Sbjct: 263 ENRPKYA---GYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQ 319

Query: 321 HPYF 324
           HPY 
Sbjct: 320 HPYI 323


>5AWM-A nrPDB
          Length = 394

 Score = 97.1 bits (240), Expect = 1e-20,   Method: Compositional matrix adjust.
 Identities = 88/337 (26%), Positives = 164/337 (48%), Gaps = 42/337 (12%)

Query: 17  THRPREYWDYESHVVEWGNQD-----DYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL- 70
           +HR      ++ + VE G+ +      Y  +R +G G    V  A +    + V +K L 
Sbjct: 19  SHRTMTTAQHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLS 78

Query: 71  KPVKK----KKIKREIKILENLRGGPNIITLADIVKDPVS----RTPALVFEHVNNTDFK 122
           +P +     K+  RE K+++ L    NII L +      +    +   LV E + + +  
Sbjct: 79  RPFQNVTHAKRAYREFKLMK-LVNHKNIIGLLNAFTPQRNLEEFQDVYLVME-LMDANLC 136

Query: 123 QLYQTLTDYD-IRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF 181
           Q+ Q   D+D + + +Y++L  + + HS GI+HRD+KP N+++  +   L+++D+GLA  
Sbjct: 137 QVIQMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADC-TLKILDFGLART 195

Query: 182 YHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQ 241
                     V +RY++ PE+++    Y  ++D+WS+GC++  MI R    F G D+ DQ
Sbjct: 196 AGTTFMMTPYVVTRYYRAPEVILGMG-YTENVDIWSVGCIMGEMI-RGGVLFPGTDHIDQ 253

Query: 242 LVRIAKVLGT------EDLYDYIDKYNIELDPRFNDILGRHSRKRWERFV--------HS 287
             +I + LGT      + L   +  Y +E  PR+       +   ++R          ++
Sbjct: 254 WNKIIEQLGTPSPSFMQRLQPTVRNY-VENRPRY-------TGYSFDRLFPDGLFPNDNN 305

Query: 288 ENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324
           +N    + +A + L K+L  D + R++  EA++H Y 
Sbjct: 306 QNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEYI 342


>2J90-A nrPDB
          Length = 304

 Score = 96.7 bits (239), Expect = 2e-20,   Method: Compositional matrix adjust.
 Identities = 81/313 (25%), Positives = 146/313 (46%), Gaps = 53/313 (16%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP---------VKKKKIKREIKILE 86
           +D Y++  +LG G+++ V +       ++   K +K          V +++I+RE+ IL 
Sbjct: 25  EDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILR 84

Query: 87  NLRGGPNIITLADIVKDPVSRTPALVFEHVNNT---DFKQLYQTLTDYDIRFYMYEILKA 143
            +R  PNIITL DI ++       L+ E V+     DF    ++LT+ +   ++ +IL  
Sbjct: 85  EIRH-PNIITLHDIFENKTD--VVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDG 141

Query: 144 LDYCHSMGIMHRDVKPHNVMIDHEHR---KLRLIDWGLAEFYHPGQEYNVRVASRYFKGP 200
           + Y HS  I H D+KP N+M+  ++    +++LID+G+A     G E+     +  F  P
Sbjct: 142 VHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFVAP 201

Query: 201 ELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDK 260
           E +V+Y+      DMWS+G +   ++    PF  G    + L  I+ V      YD+ ++
Sbjct: 202 E-IVNYEPLGLEADMWSIGVITYILLSGASPFL-GETKQETLTNISAV-----NYDFDEE 254

Query: 261 YNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAME 320
           Y       F++                      S  A DF+ +LL  D + R+T  +++E
Sbjct: 255 Y-------FSN---------------------TSELAKDFIRRLLVKDPKRRMTIAQSLE 286

Query: 321 HPYFYTVVKDQAR 333
           H +   + +   R
Sbjct: 287 HSWIKAIRRRNVR 299


>3LIJ-A nrPDB
          Length = 494

 Score = 95.9 bits (237), Expect = 3e-20,   Method: Compositional matrix adjust.
 Identities = 83/340 (24%), Positives = 152/340 (44%), Gaps = 57/340 (16%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK-----KKKIKREIKILENLRGGPN 93
           YQ V+KLG G Y EV    +   + +  +KI++          K+  E+ +L+ L   PN
Sbjct: 39  YQRVKKLGSGAYGEVLLCRDKVTHVERAIKIIRKTSVSTSSNSKLLEEVAVLK-LLDHPN 97

Query: 94  IITLADIVKDPVSRTPALVFEHVNNTD-FKQLYQTL--TDYDIRFYMYEILKALDYCHSM 150
           I+ L D  +D   R   LV E     + F ++   +   + D    + ++L  + Y H  
Sbjct: 98  IMKLYDFFEDK--RNYYLVMECYKGGELFDEIIHRMKFNEVDAAVIIKQVLSGVTYLHKH 155

Query: 151 GIMHRDVKPHNVMIDHEHRK--LRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQM 208
            I+HRD+KP N++++ + +   ++++D+GL+  +   ++   R+ + Y+  PE+L   + 
Sbjct: 156 NIVHRDLKPENLLLESKEKDALIKIVDFGLSAVFENQKKMKERLGTAYYIAPEVL--RKK 213

Query: 209 YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPR 268
           YD   D+WS+G +L  ++    P F G  + + L ++ K            KY  +  P 
Sbjct: 214 YDEKCDVWSIGVILF-ILLAGYPPFGGQTDQEILRKVEK-----------GKYTFD-SPE 260

Query: 269 FNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVV 328
           + +                     VS  A D + ++L++D Q R++A++A+EHP+     
Sbjct: 261 WKN---------------------VSEGAKDLIKQMLQFDSQRRISAQQALEHPWI---- 295

Query: 329 KDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLGPLA 368
                M S    G   P S AN +  +        L   A
Sbjct: 296 ---KEMCSKKESGIELP-SLANAIENMRKFQNSQKLAQAA 331


>3NCG-A nrPDB
          Length = 486

 Score = 95.1 bits (235), Expect = 4e-20,   Method: Compositional matrix adjust.
 Identities = 81/344 (23%), Positives = 148/344 (43%), Gaps = 65/344 (18%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK-----IKREIKILENLRGGPN 93
           Y +V  LG+G + EV +  +    ++  VK++     K      I RE+++L+ L   PN
Sbjct: 24  YNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKL-DHPN 82

Query: 94  IITLADIVKDPVS-------RTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDY 146
           I+ L +I++D  S        T   +F+ +         +  +++D    + ++   + Y
Sbjct: 83  IMKLFEILEDSSSFYIVGELYTGGELFDEIIKR------KRFSEHDAARIIKQVFSGITY 136

Query: 147 CHSMGIMHRDVKPHNVMIDHEHR--KLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLV 204
            H   I+HRD+KP N++++ + +   +++ID+GL+  +    +   R+ + Y+  PE+L 
Sbjct: 137 MHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVL- 195

Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIE 264
               YD   D+WS G +L  ++    P F+G + YD L R+              KY  +
Sbjct: 196 -RGTYDEKCDVWSAGVILY-ILLSGTPPFYGKNEYDILKRVE-----------TGKYAFD 242

Query: 265 LDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324
           L              +W           +S +A D + K+L +    R+TA + +EHP+ 
Sbjct: 243 L-------------PQW---------RTISDDAKDLIRKMLTFHPSLRITATQCLEHPWI 280

Query: 325 YTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLGPLA 368
                      SS  P  S   S  + M+ I        L   A
Sbjct: 281 QKY--------SSETPTISDLPSLESAMTNIRQFQAEKKLAQAA 316


>3DFA-A nrPDB
          Length = 286

 Score = 95.1 bits (235), Expect = 5e-20,   Method: Compositional matrix adjust.
 Identities = 74/295 (25%), Positives = 141/295 (47%), Gaps = 49/295 (16%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK-----IKREIKILENLRGGPN 93
           Y +V  LG+G + EV +  +    ++  VK++     K      I RE+++L+ L   PN
Sbjct: 24  YNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKL-DHPN 82

Query: 94  IITLADIVKDPVSRTPALVFE-HVNNTDFKQLYQT--LTDYDIRFYMYEILKALDYCHSM 150
           I+ L +I++D  S +  +V E +     F ++ +    +++D    + ++   + Y H  
Sbjct: 83  IMKLFEILED--SSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMHKH 140

Query: 151 GIMHRDVKPHNVMIDHEHR--KLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQM 208
            I+HRD+KP N++++ + +   +++ID+GL+  +    +   R+ + Y+  PE+L     
Sbjct: 141 NIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVL--RGT 198

Query: 209 YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPR 268
           YD   D+WS G +L  ++    P F+G + YD L R+              KY  +L P+
Sbjct: 199 YDEKCDVWSAGVILY-ILLSGTPPFYGKNEYDILKRVE-----------TGKYAFDL-PQ 245

Query: 269 FNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323
           +  I                     S +A D + K+L +    R+TA + +EHP+
Sbjct: 246 WRTI---------------------SDDAKDLIRKMLTFHPSLRITATQCLEHPW 279


>1KOB-A nrPDB
          Length = 387

 Score = 94.7 bits (234), Expect = 6e-20,   Method: Compositional matrix adjust.
 Identities = 76/299 (25%), Positives = 130/299 (43%), Gaps = 52/299 (17%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK---PVKKKKIKREIKILENLRGGPN 93
           D Y ++ +LG G +  V   +        V K +    P+ K  +K EI I+  L   P 
Sbjct: 51  DYYDILEELGSGAFGVVHRCVEKATGRVFVAKFINTPYPLDKYTVKNEISIMNQLHH-PK 109

Query: 94  IITLADIVKDPVSRTPAL-------VFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDY 146
           +I L D  +D       L       +F+ +   D+K     +++ ++  YM +  + L +
Sbjct: 110 LINLHDAFEDKYEMVLILEFLSGGELFDRIAAEDYK-----MSEAEVINYMRQACEGLKH 164

Query: 147 CHSMGIMHRDVKPHNVMID-HEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVD 205
            H   I+H D+KP N+M +  +   +++ID+GLA   +P +   V  A+  F  PE +VD
Sbjct: 165 MHEHSIVHLDIKPENIMCETKKASSVKIIDFGLATKLNPDEIVKVTTATAEFAAPE-IVD 223

Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIEL 265
            +   +  DMW++G +   ++    P F G D+ + L  +                    
Sbjct: 224 REPVGFYTDMWAIGVLGYVLLSGLSP-FAGEDDLETLQNV-------------------- 262

Query: 266 DPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324
                       R  WE     +    VSPEA DF+  LL+ + + RLT  +A+EHP+ 
Sbjct: 263 -----------KRCDWE--FDEDAFSSVSPEAKDFIKNLLQKEPRKRLTVHDALEHPWL 308


>3DXN-A nrPDB
          Length = 287

 Score = 94.4 bits (233), Expect = 7e-20,   Method: Compositional matrix adjust.
 Identities = 79/302 (26%), Positives = 132/302 (43%), Gaps = 50/302 (16%)

Query: 34  GNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK------PVKKKKIKREIKILEN 87
           G  D YQ V+KLG G Y EV    +     +  +KI+K            +  E+ +L+ 
Sbjct: 18  GLSDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQ 77

Query: 88  LRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQ---LYQTLTDYDIRFYMYEILKAL 144
           L   PNI+ L +  +D   R   LV E     +      L Q  ++ D    M ++L   
Sbjct: 78  L-DHPNIMKLYEFFED--KRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLSGT 134

Query: 145 DYCHSMGIMHRDVKPHNVMIDHEHRK--LRLIDWGLAEFYHPGQEYNVRVASRYFKGPEL 202
            Y H   I+HRD+KP N++++ + R   ++++D+GL+  +  G +   R+ + Y+  PE+
Sbjct: 135 TYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAPEV 194

Query: 203 LVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYN 262
           L   + YD   D+WS G +L  ++    PF  G  + + L R+             +K  
Sbjct: 195 L--RKKYDEKCDVWSCGVILYILLCGYPPF-GGQTDQEILKRV-------------EKGK 238

Query: 263 IELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHP 322
              DP             W +         VS EA   +  +L Y+   R++A EA+ HP
Sbjct: 239 FSFDP-----------PDWTQ---------VSDEAKQLVKLMLTYEPSKRISAEEALNHP 278

Query: 323 YF 324
           + 
Sbjct: 279 WI 280


>4MVF-A nrPDB
          Length = 506

 Score = 93.6 bits (231), Expect = 1e-19,   Method: Compositional matrix adjust.
 Identities = 78/311 (25%), Positives = 143/311 (45%), Gaps = 47/311 (15%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKR---EIKILENLRGGP 92
           +D Y +  KLG+G Y  V++ I+   N+   +K  K  + K I R   EI+I++ L   P
Sbjct: 56  EDKYIIDEKLGQGTYGCVYKGIDKVTNQLYAIKEEKKDRLKNINRFFQEIEIMKKL-DHP 114

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNTD-FKQLYQ--TLTDYDIRFYMYEILKALDYCHS 149
           NI+ L +  ++       L+ E  +  + F  + +  + T+ +    M +I  A+ Y HS
Sbjct: 115 NIVKLYETYEN--DNYIYLIMELCSGRELFDSIIENGSFTEKNAATIMKQIFSAIFYLHS 172

Query: 150 MGIMHRDVKPHNVMIDHEHRK--LRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQ 207
           + I+HRD+KP N +   E++   L++ID+GL++    G+    +  + Y+  P++L    
Sbjct: 173 LNIVHRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFTTTKAGTPYYVAPQVLDG-- 230

Query: 208 MYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDP 267
            YD   D+WS G ++ +++    PF+   D                              
Sbjct: 231 KYDKKCDIWSSGVIMYTLLCGYPPFYGDTD------------------------------ 260

Query: 268 RFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTV 327
             N++L +   K+ E   +  +   +S +A + + KLL Y+   R T  EA+ HP+   +
Sbjct: 261 --NEVLKK--VKKGEFCFYENDWGSISSDAKNLITKLLTYNPNERCTIEEALNHPWITQM 316

Query: 328 VKDQARMGSSS 338
            K    +  SS
Sbjct: 317 TKSHEHVELSS 327


>4F9B-A nrPDB
          Length = 361

 Score = 92.8 bits (229), Expect = 2e-19,   Method: Compositional matrix adjust.
 Identities = 82/337 (24%), Positives = 144/337 (42%), Gaps = 54/337 (16%)

Query: 39  YQLVRKLGRGKYSEVFEA---INITNNEKVVVKILKPVKKK-KIKREIKILENLRGGPNI 94
           +++  K+G G +S V+ A   + +   EK+ +K L P     +I  E++ L    G  N+
Sbjct: 23  FKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQCLTVAGGQDNV 82

Query: 95  ITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMH 154
           + +    +   +    +   ++ +  F  +  +L+  ++R YM  + KAL   H  GI+H
Sbjct: 83  MGVKYCFRK--NDHVVIAMPYLEHESFLDILNSLSFQEVREYMLNLFKALKRIHQFGIVH 140

Query: 155 RDVKPHNVMIDHEHRKLRLIDWGLAEFYHPG----------------------------- 185
           RDVKP N + +   +K  L+D+GLA+  H                               
Sbjct: 141 RDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNKCSICLSRR 200

Query: 186 QEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRI 245
           Q+   R  +  F+ PE+L        ++DMWS G +  S++  + PF+   D+   L +I
Sbjct: 201 QQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDDLTALAQI 260

Query: 246 AKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERF------------------VHS 287
             + G+ +       +   +     ++  +  RK  ER                    + 
Sbjct: 261 MTIRGSRETIQAAKTFGKSILCS-KEVPAQDLRKLCERLRGMDSSTPKLTSDIQGHATNL 319

Query: 288 ENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324
           E  + V  EA D LDKLL  +  SR+TA EA+ HP+F
Sbjct: 320 EGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFF 356


>4YNZ-A nrPDB
          Length = 342

 Score = 92.8 bits (229), Expect = 2e-19,   Method: Compositional matrix adjust.
 Identities = 67/217 (30%), Positives = 112/217 (51%), Gaps = 14/217 (6%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK-----KIKREIKILENLRGGPN 93
           Y+L + LG+G+   V   I+    +KV +KI+   K       K++REI IL+ L   P+
Sbjct: 12  YRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSESVLMKVEREIAILK-LIEHPH 70

Query: 94  IITLADIVKDPVSRTPALVFEHVNNTD-FKQLYQT--LTDYDIRFYMYEILKALDYCHSM 150
           ++ L D+ ++   +   LV EHV+  + F  L +   LT  + R +  +I+ ALD+CHS 
Sbjct: 71  VLKLHDVYEN--KKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSH 128

Query: 151 GIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYD 210
            I HRD+KP N+++D E   +R+ D+G+A              S ++  PE++   +   
Sbjct: 129 SICHRDLKPENLLLD-ERNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDG 187

Query: 211 YSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAK 247
              D+WS G +L +++    PF    DN  QL+   K
Sbjct: 188 RKADVWSCGVILFALLVGALPF--DDDNLRQLLEKVK 222


>3HZT-A nrPDB
          Length = 467

 Score = 92.8 bits (229), Expect = 2e-19,   Method: Compositional matrix adjust.
 Identities = 79/302 (26%), Positives = 132/302 (43%), Gaps = 50/302 (16%)

Query: 34  GNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK------PVKKKKIKREIKILEN 87
           G  D YQ V+KLG G Y EV    +     +  +KI+K            +  E+ +L+ 
Sbjct: 1   GLSDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQ 60

Query: 88  LRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQ---LYQTLTDYDIRFYMYEILKAL 144
           L   PNI+ L +  +D   R   LV E     +      L Q  ++ D    M ++L   
Sbjct: 61  L-DHPNIMKLYEFFEDK--RNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLSGT 117

Query: 145 DYCHSMGIMHRDVKPHNVMIDHEHRK--LRLIDWGLAEFYHPGQEYNVRVASRYFKGPEL 202
            Y H   I+HRD+KP N++++ + R   ++++D+GL+  +  G +   R+ + Y+  PE+
Sbjct: 118 TYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAPEV 177

Query: 203 LVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYN 262
           L   + YD   D+WS G +L  ++    PF  G  + + L R+             +K  
Sbjct: 178 L--RKKYDEKCDVWSCGVILYILLCGYPPF-GGQTDQEILKRV-------------EKGK 221

Query: 263 IELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHP 322
              DP             W +         VS EA   +  +L Y+   R++A EA+ HP
Sbjct: 222 FSFDP-----------PDWTQ---------VSDEAKQLVKLMLTYEPSKRISAEEALNHP 261

Query: 323 YF 324
           + 
Sbjct: 262 WI 263


>6FDY-U nrPDB
          Length = 276

 Score = 92.4 bits (228), Expect = 3e-19,   Method: Compositional matrix adjust.
 Identities = 66/214 (30%), Positives = 105/214 (49%), Gaps = 20/214 (9%)

Query: 33  WG--NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKR--------EI 82
           WG    D + L  +LG G Y+ V++A    +  +VV   +K V KK + +        EI
Sbjct: 5   WGPPRLDGFILTERLGSGTYATVYKAYAKKDTREVVA--IKCVAKKSLNKASVENLLTEI 62

Query: 83  KILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYE 139
           +IL+ +R  P+I+ L D   D  S    L+ E     D  +   T   L +   R +M +
Sbjct: 63  EILKGIRH-PHIVQLKDFQWD--SDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQ 119

Query: 140 ILKALDYCHSMGIMHRDVKPHNVMIDH-EHRKLRLIDWGLAEFYHPGQEYNVRVASRYFK 198
           +  AL + H   I H D+KP N+++   E   L+L D+G A+   P  E +V   S  + 
Sbjct: 120 LASALQFLHERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYM 179

Query: 199 GPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPF 232
            PE++   Q YD  +D+WS+G +L   +F + PF
Sbjct: 180 APEMVCQRQ-YDARVDLWSMGVILYEALFGQPPF 212


>5ES1-A nrPDB
          Length = 328

 Score = 91.7 bits (226), Expect = 4e-19,   Method: Compositional matrix adjust.
 Identities = 58/208 (27%), Positives = 113/208 (54%), Gaps = 13/208 (6%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKI-----LKPVKKKKIKREIKILENLRGGP 92
           +Y+L+R +G+G +++V  A +I    +V +KI     L P   +K+ RE++I++ L   P
Sbjct: 16  NYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGL-NHP 74

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNT---DFKQLYQTLTDYDIRFYMYEILKALDYCHS 149
           NI+ L ++++    +T  LV E+ +     D+   +  + + + R    +I+ A+ YCH 
Sbjct: 75  NIVKLFEVIE--TEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQ 132

Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMY 209
             I+HRD+K  N+++D E   +++ D+G +  +  G + +    S  +  PEL    +  
Sbjct: 133 KNIVHRDLKAENLLLDAEA-NIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYD 191

Query: 210 DYSLDMWSLGCMLASMIFRKEPFFHGHD 237
              +D+WSLG +L +++    P F GH+
Sbjct: 192 GPEVDIWSLGVILYTLVSGSLP-FDGHN 218


>4JG6-A nrPDB
          Length = 355

 Score = 91.7 bits (226), Expect = 6e-19,   Method: Compositional matrix adjust.
 Identities = 84/299 (28%), Positives = 134/299 (44%), Gaps = 50/299 (16%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIIT 96
           D Y++   +G G YS     I+   N +  VKI+   K+   + EI+IL      PNIIT
Sbjct: 35  DGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTE-EIEILLRYGQHPNIIT 93

Query: 97  LADIVKDPVSRTPALVFEHVNNTDF--KQLYQTL-TDYDIRFYMYEILKALDYCHSMGIM 153
           L D+  D   +   +V E +   +   K L Q   ++ +    ++ I K ++Y H+ G++
Sbjct: 94  LKDVYDD--GKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVV 151

Query: 154 HRDVKPHNVMIDHEH---RKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLVDYQ 207
           HRD+KP N++   E      +R+ D+G A+      E  + +   Y   F  PE+L + Q
Sbjct: 152 HRDLKPSNILYVDESGNPESIRICDFGFAKQLRA--ENGLLMTPCYTANFVAPEVL-ERQ 208

Query: 208 MYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQ--LVRIAKVLGTEDLYDYIDKYNIEL 265
            YD + D+WSLG +L +M+    PF +G D+  +  L RI              K+++  
Sbjct: 209 GYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGS-----------GKFSL-- 255

Query: 266 DPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324
                      S   W           VS  A D + K+L  D   RLTA   + HP+ 
Sbjct: 256 -----------SGGYWNS---------VSDTAKDLVSKMLHVDPHQRLTAALVLRHPWI 294


>2Y7J-A nrPDB
          Length = 365

 Score = 91.3 bits (225), Expect = 7e-19,   Method: Compositional matrix adjust.
 Identities = 74/299 (24%), Positives = 140/299 (46%), Gaps = 56/299 (18%)

Query: 45  LGRGKYSEVFEAINITNNEKVVVKILKPVKKK-----------KIKREIKILENLRGGPN 93
           +GRG  S V   ++     +  VKI++   ++             +RE  IL  + G P+
Sbjct: 102 IGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHILRQVAGHPH 161

Query: 94  IITLADIVKDPVSRTPALVFEHVNNTD-FKQLYQ--TLTDYDIRFYMYEILKALDYCHSM 150
           IITL D  +   S    LVF+ +   + F  L +   L++ + R  M  +L+A+ + H+ 
Sbjct: 162 IITLIDSYES--SSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLEAVSFLHAN 219

Query: 151 GIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLV-----D 205
            I+HRD+KP N+++D ++ ++RL D+G +    PG++      +  +  PE+L       
Sbjct: 220 NIVHRDLKPENILLD-DNMQIRLSDFGFSCHLEPGEKLRELCGTPGYLAPEILKCSMDET 278

Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIEL 265
           +  Y   +D+W+ G +L +++    PF+H      Q++ +  ++  E  Y +        
Sbjct: 279 HPGYGKEVDLWACGVILFTLLAGSPPFWHRR----QILMLRMIM--EGQYQFS------- 325

Query: 266 DPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324
            P ++D                      S    D + +LL+ D ++RLTA +A++HP+F
Sbjct: 326 SPEWDD---------------------RSSTVKDLISRLLQVDPEARLTAEQALQHPFF 363


>3KN6-A nrPDB
          Length = 325

 Score = 90.9 bits (224), Expect = 8e-19,   Method: Compositional matrix adjust.
 Identities = 58/201 (28%), Positives = 108/201 (53%), Gaps = 10/201 (4%)

Query: 43  RKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVK 102
           + LG G +S   + ++  +N+   VKI+    +   ++EI  L+   G PNI+ L ++  
Sbjct: 17  KPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALKLCEGHPNIVKLHEVFH 76

Query: 103 DPVSRTPALVFEHVNNTD-FKQLYQT--LTDYDIRFYMYEILKALDYCHSMGIMHRDVKP 159
           D +     LV E +N  + F+++ +    ++ +  + M +++ A+ + H +G++HRD+KP
Sbjct: 77  DQLH--TFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLKP 134

Query: 160 HNVMIDHEHRKL--RLIDWGLAEFYHP-GQEYNVRVASRYFKGPELLVDYQMYDYSLDMW 216
            N++   E+  L  ++ID+G A    P  Q       + ++  PELL +   YD S D+W
Sbjct: 135 ENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELL-NQNGYDESCDLW 193

Query: 217 SLGCMLASMIFRKEPFFHGHD 237
           SLG +L +M+  + P F  HD
Sbjct: 194 SLGVILYTMLSGQVP-FQSHD 213


>3TAC-A nrPDB
          Length = 361

 Score = 90.9 bits (224), Expect = 9e-19,   Method: Compositional matrix adjust.
 Identities = 82/310 (26%), Positives = 136/310 (43%), Gaps = 63/310 (20%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK--------KKKIKREIKILEN 87
           +D Y+L   +G+G +S V   IN    ++  VKI+   K         + +KRE  I   
Sbjct: 25  EDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHM 84

Query: 88  LRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRF---------YMY 138
           L+  P+I+ L +           +VFE ++  D    ++ +   D  F         YM 
Sbjct: 85  LKH-PHIVELLETYSS--DGMLYMVFEFMDGADL--CFEIVKRADAGFVYSEAVASHYMR 139

Query: 139 EILKALDYCHSMGIMHRDVKPHNVMIDHEHRK--LRLIDWGLA-EFYHPGQEYNVRVASR 195
           +IL+AL YCH   I+HRDVKPH V++  +     ++L  +G+A +    G     RV + 
Sbjct: 140 QILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTP 199

Query: 196 YFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGT-EDL 254
           +F  PE +V  + Y   +D+W  G +L  ++    PF+                GT E L
Sbjct: 200 HFMAPE-VVKREPYGKPVDVWGCGVILFILLSGCLPFY----------------GTKERL 242

Query: 255 YDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT 314
           ++ I K   +++PR           +W           +S  A D + ++L  D   R+T
Sbjct: 243 FEGIIKGKYKMNPR-----------QWSH---------ISESAKDLVRRMLMLDPAERIT 282

Query: 315 AREAMEHPYF 324
             EA+ HP+ 
Sbjct: 283 VYEALNHPWL 292


>2YAB-A nrPDB
          Length = 361

 Score = 90.5 bits (223), Expect = 1e-18,   Method: Compositional matrix adjust.
 Identities = 85/320 (26%), Positives = 148/320 (46%), Gaps = 55/320 (17%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP---------VKKKKIKREIKILE 86
           +D Y +  +LG G+++ V +    +   +   K +K          V +++I+RE+ IL 
Sbjct: 11  EDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIEREVSILR 70

Query: 87  NLRGGPNIITLADIVKDPVSRTPA-LVFEHVNNT---DFKQLYQTLTDYDIRFYMYEILK 142
            +   PNIITL D+ ++   RT   L+ E V+     DF    ++L++ +   ++ +IL 
Sbjct: 71  QVLH-PNIITLHDVYEN---RTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILD 126

Query: 143 ALDYCHSMGIMHRDVKPHNVMIDHEHR---KLRLIDWGLAEFYHPGQEYNVRVASRYFKG 199
            ++Y H+  I H D+KP N+M+  ++     ++LID+GLA     G E+     +  F  
Sbjct: 127 GVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVA 186

Query: 200 PELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYID 259
           PE +V+Y+      DMWS+G +   ++    PF  G    + L  I  V      YD+ +
Sbjct: 187 PE-IVNYEPLGLEADMWSIGVITYILLSGASPFL-GDTKQETLANITAV-----SYDFDE 239

Query: 260 KYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAM 319
           ++                         S+   L    A DF+ KLL  + + RLT +EA+
Sbjct: 240 EF------------------------FSQTSEL----AKDFIRKLLVKETRKRLTIQEAL 271

Query: 320 EHPYFYTVVKDQARMGSSSM 339
            HP+   V   QA +   S+
Sbjct: 272 RHPWITPVDTQQAMVRRESV 291


>2VN9-A nrPDB
          Length = 301

 Score = 89.4 bits (220), Expect = 3e-18,   Method: Compositional matrix adjust.
 Identities = 80/301 (26%), Positives = 142/301 (47%), Gaps = 53/301 (17%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK-----KKKIKREIKILENLRGG 91
           D+YQL  +LG+G +S V   + I   ++   KI+   K      +K++RE +I   L+  
Sbjct: 4   DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKH- 62

Query: 92  PNIITLADIVKDPVSRTPALVFEHVNNTD-FKQLY--QTLTDYDIRFYMYEILKALDYCH 148
           PNI+ L D + +       LVF+ V   + F+ +   +  ++ D    + +IL+++++CH
Sbjct: 63  PNIVRLHDSISEEGFHY--LVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCH 120

Query: 149 SMGIMHRDVKPHNVMIDHEHR--KLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLVD 205
             GI+HRD+KP N+++  + +   ++L D+GLA E     Q +     +  +  PE+L  
Sbjct: 121 LNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRK 180

Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFF--HGHDNYDQLVRIAKVLGTEDLYDYIDKYNI 263
              Y   +DMW+ G +L  ++    PF+    H  Y Q+   A        YD+      
Sbjct: 181 -DPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGA--------YDF------ 225

Query: 264 ELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323
                            W+          V+PEA D ++K+L  +   R+TA EA++HP+
Sbjct: 226 -------------PSPEWDT---------VTPEAKDLINKMLTINPAKRITASEALKHPW 263

Query: 324 F 324
            
Sbjct: 264 I 264


>1ZWS-A nrPDB
          Length = 288

 Score = 89.4 bits (220), Expect = 3e-18,   Method: Compositional matrix adjust.
 Identities = 83/313 (26%), Positives = 145/313 (46%), Gaps = 55/313 (17%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP---------VKKKKIKREIKILE 86
           +D Y +  +LG G+++ V +    +   +   K +K          V +++I+RE+ IL 
Sbjct: 11  EDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILR 70

Query: 87  NLRGGPNIITLADIVKDPVSRTPA-LVFEHVNNT---DFKQLYQTLTDYDIRFYMYEILK 142
            +    N+ITL D+ ++   RT   L+ E V+     DF    ++L++ +   ++ +IL 
Sbjct: 71  QVLH-HNVITLHDVYEN---RTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILD 126

Query: 143 ALDYCHSMGIMHRDVKPHNVMIDHEHR---KLRLIDWGLAEFYHPGQEYNVRVASRYFKG 199
            ++Y H+  I H D+KP N+M+  ++     ++LID+GLA     G E+     +  F  
Sbjct: 127 GVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVA 186

Query: 200 PELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYID 259
           PE+ V+Y+      DMWS+G +   ++    PF  G    + L  I  V      YD+ +
Sbjct: 187 PEI-VNYEPLGLEADMWSIGVITYILLSGASPFL-GDTKQETLANITSVS-----YDFDE 239

Query: 260 KYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAM 319
           ++                      F H+      S  A DF+ KLL  + + RLT +EA+
Sbjct: 240 EF----------------------FSHT------SELAKDFIRKLLVKETRKRLTIQEAL 271

Query: 320 EHPYFYTVVKDQA 332
            HP+   V   QA
Sbjct: 272 RHPWITPVDNQQA 284


>5YKS-A nrPDB
          Length = 377

 Score = 89.0 bits (219), Expect = 3e-18,   Method: Compositional matrix adjust.
 Identities = 55/209 (26%), Positives = 107/209 (51%), Gaps = 12/209 (5%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIK-----REIKILENLRGGPN 93
           Y L + LGRG ++ V  A ++   EKV VK++   K   +      +E++ ++ L   PN
Sbjct: 37  YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMK-LVQHPN 95

Query: 94  IITLADIVKDPVSRTPALVFEHVNNTD----FKQLYQTLTDYDIRFYMYEILKALDYCHS 149
           I+ L +++         L+ E  +  D      +  + L +   + Y  +I+ A+ YCH 
Sbjct: 96  IVRLYEVID--TQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHK 153

Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMY 209
           + ++HRD+KP NV+   +   ++L D+G +  + PG++      S  +  PE+L+  +  
Sbjct: 154 LHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYD 213

Query: 210 DYSLDMWSLGCMLASMIFRKEPFFHGHDN 238
             ++D+WSLG +L  ++  + PF   +D+
Sbjct: 214 APAVDIWSLGVILFMLVCGQPPFQEANDS 242


>4C0T-A nrPDB
          Length = 974

 Score = 88.6 bits (218), Expect = 4e-18,   Method: Compositional matrix adjust.
 Identities = 69/233 (29%), Positives = 114/233 (48%), Gaps = 24/233 (10%)

Query: 35  NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP---VKKKKIKR---EIKILENL 88
           N  D++  ++LG G YS V  A +    ++  VK+L     +K+KK+K    E   L  L
Sbjct: 264 NVTDFKFGKELGEGSYSTVILATDKITGKQYAVKVLDKRHIIKEKKVKYVNIEKHALNRL 323

Query: 89  RGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQL---YQTLTDYDIRFYMYEILKALD 145
                +I+L    +D  S     V ++ +N +   L   Y TL +   R +  +IL A+ 
Sbjct: 324 SNRLGVISLYFTFQDKDSL--YFVLDYASNGELLTLIKRYNTLNEECTRHFGAQILDAIK 381

Query: 146 YCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHP----GQEYNVRVASRYFKG-- 199
           Y H  G++HRD+KP N+++D + R +++ D+G A          +EY V V ++ F G  
Sbjct: 382 YMHDNGVIHRDLKPENILLDDKMR-IQITDFGTARLLEKKNDESEEYPVDVRAKSFVGTA 440

Query: 200 ----PELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKV 248
               PELL + +      D+W+ GC++  MI  K P F   + Y    +I K+
Sbjct: 441 EYVSPELL-ENKYCGKPGDVWAFGCIIYQMIAGKPP-FKATNEYLTFQKITKL 491


>6QAU-A nrPDB
          Length = 280

 Score = 88.2 bits (217), Expect = 5e-18,   Method: Compositional matrix adjust.
 Identities = 59/206 (28%), Positives = 105/206 (50%), Gaps = 24/206 (11%)

Query: 45  LGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKR-------EIKILENLRGGPNIITL 97
           +G G ++ VF   +    +  V   +K + KK + +       EIKIL+ L+   NI+ L
Sbjct: 19  VGHGAFAVVFRGRHRQKTDWEVA--IKSINKKNLSKSQILLGKEIKILKELQH-ENIVAL 75

Query: 98  ADIVKDPVSRTPALVFEHVNN---TDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMH 154
            D+ + P   +  LV E+ N     D+ Q   TL++  IR ++++I  A+   HS GI+H
Sbjct: 76  YDVQELP--NSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRILHSKGIIH 133

Query: 155 RDVKPHNVMIDHEHR--------KLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDY 206
           RD+KP N+++ + +R        ++++ D+G A + H          S  +  PE+++  
Sbjct: 134 RDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAADLCGSPMYMAPEVIMS- 192

Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPF 232
           Q YD   D+WS+G ++   +  K PF
Sbjct: 193 QHYDAKADLWSIGTVIYQCLVGKPPF 218


>5XZW-A nrPDB
          Length = 471

 Score = 88.2 bits (217), Expect = 6e-18,   Method: Compositional matrix adjust.
 Identities = 80/308 (25%), Positives = 137/308 (44%), Gaps = 58/308 (18%)

Query: 38  DYQLVRKL-GRGKYSEVFEAINITNNEKVVVKILKPVK----KKKIKREIKILENLRGGP 92
           D+ ++ ++ G+G ++ V +AI  T  +   VKI+   K       + RE+++L+ L   P
Sbjct: 196 DFSIIDEVVGQGAFATVKKAIERTTGKTFAVKIISKRKVIGNMDGVTRELEVLQKLNH-P 254

Query: 93  NIITLADIVKDPVSRTPALVFEHVNN---TDFKQLYQTLTDYDIRFYMYEILKALDYCHS 149
            I+ L    +D  + +  +V E V+     DF   +  + +   R    +IL A+ Y HS
Sbjct: 255 RIVRLKGFYED--TESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHS 312

Query: 150 MGIMHRDVKPHNVMIDHEHRKL-RLIDWGLAEFYHPGQEYNVRVASRYFKGPELL----- 203
           MGI HRD+KP N++I+ +   L ++ D+GLA+    G        +  +  PE++     
Sbjct: 313 MGISHRDLKPDNILIEQDDPVLVKITDFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDT 372

Query: 204 -------VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYD 256
                   +   Y   +DMWS+GC++  ++    PF       DQ            LY 
Sbjct: 373 SVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPF--SGSTQDQ------------LYK 418

Query: 257 YIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAR 316
            I +             G +     + F        +S EA DF+D LL+ D  +R TA 
Sbjct: 419 QIGR-------------GSYHEGPLKDF-------RISEEARDFIDSLLQVDPNNRSTAA 458

Query: 317 EAMEHPYF 324
           +A+ HP+ 
Sbjct: 459 KALNHPWI 466


>2HW6-A nrPDB
          Length = 307

 Score = 87.8 bits (216), Expect = 7e-18,   Method: Compositional matrix adjust.
 Identities = 80/315 (25%), Positives = 140/315 (44%), Gaps = 54/315 (17%)

Query: 36  QDDYQLVRKL-GRGKYSEVFEAINITNNEKVVVKILKPV---KKKKIKREIKILENLRGG 91
           +D Y+L  +L G G Y++V  A+++ N ++  VKI++      + ++ RE++ L   +G 
Sbjct: 11  EDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGN 70

Query: 92  PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIR---FYMYEILKALDYCH 148
            NI+ L +  +D       LVFE +         Q    ++ R     + ++  ALD+ H
Sbjct: 71  KNILELIEFFEDDTRFY--LVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLH 128

Query: 149 SMGIMHRDVKPHNVMIDHEHR--KLRLIDWGLAEFYHPGQ--------EYNVRVASRYFK 198
           + GI HRD+KP N++ +   +   +++ D+ L                E      S  + 
Sbjct: 129 TKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYM 188

Query: 199 GPELLVDY----QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYD------QLVRIAKV 248
            PE++  +      YD   D+WSLG +L  M+    PF  GH   D      ++ R+ + 
Sbjct: 189 APEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFV-GHCGADCGWDRGEVCRVCQ- 246

Query: 249 LGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYD 308
                L++ I +   E    F D       K W           +S EA D + KLL  D
Sbjct: 247 ---NKLFESIQEGKYE----FPD-------KDWAH---------ISSEAKDLISKLLVRD 283

Query: 309 HQSRLTAREAMEHPY 323
            + RL+A + ++HP+
Sbjct: 284 AKQRLSAAQVLQHPW 298


>3D2K-A nrPDB
          Length = 272

 Score = 87.8 bits (216), Expect = 7e-18,   Method: Compositional matrix adjust.
 Identities = 76/297 (25%), Positives = 138/297 (46%), Gaps = 55/297 (18%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK------IKREIKILENLRG 90
           +D+ + R LG+GK+  V+ A    +   + +K+L   + +K      ++RE++I  +LR 
Sbjct: 12  EDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVEHQLRREVEIQSHLRH 71

Query: 91  GPNIITLADIVKDPVSRTPALVFEHVN-NTDFKQLYQTLTDYD---IRFYMYEILKALDY 146
            PNI+ L     D       L+ E+    T +++L Q L+ +D      Y+ E+  AL Y
Sbjct: 72  -PNILRLYGYFHDATR--VYLILEYAPLGTVYREL-QKLSRFDEQRTATYITELANALSY 127

Query: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDY 206
           CHS  ++HRD+KP N+++   + +L++ D+G +  + P         +  +  PE +++ 
Sbjct: 128 CHSKRVIHRDIKPENLLLG-SNGELKIADFGWS-VHAPSSRRTTLCGTLDYLPPE-MIEG 184

Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 266
           +M+D  +D+WSLG +    +    P F  H   +   RI++V  T               
Sbjct: 185 RMHDEKVDLWSLGVLCYEFLVGMPP-FEAHTYQETYRRISRVEFT--------------- 228

Query: 267 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323
             F D                     V+  A D + +LL+++   RLT  E +EHP+
Sbjct: 229 --FPD--------------------FVTEGARDLISRLLKHNASQRLTLAEVLEHPW 263


>2VZ6-A nrPDB
          Length = 313

 Score = 87.4 bits (215), Expect = 8e-18,   Method: Compositional matrix adjust.
 Identities = 78/302 (25%), Positives = 141/302 (46%), Gaps = 53/302 (17%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK-----KKKIKREIKILENLRG 90
           Q  YQL  +LG+G +S V   + +   ++   KI+   K      +K++RE +I   L+ 
Sbjct: 21  QSMYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKH 80

Query: 91  GPNIITLADIVKDPVSRTPALVFEHVNNTD-FKQLY--QTLTDYDIRFYMYEILKALDYC 147
            PNI+ L D + +       L+F+ V   + F+ +   +  ++ D    + +IL+A+ +C
Sbjct: 81  -PNIVRLHDSISEEGHHY--LIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHC 137

Query: 148 HSMGIMHRDVKPHNVMIDHEHR--KLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLV 204
           H MG++HRD+KP N+++  + +   ++L D+GLA E     Q +     +  +  PE+L 
Sbjct: 138 HQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLR 197

Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPFF--HGHDNYDQLVRIAKVLGTEDLYDYIDKYN 262
               Y   +D+W+ G +L  ++    PF+    H  Y Q+   A        YD+     
Sbjct: 198 K-DPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGA--------YDF----- 243

Query: 263 IELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHP 322
                             W+          V+PEA D ++K+L  +   R+TA EA++HP
Sbjct: 244 --------------PSPEWDT---------VTPEAKDLINKMLTINPSKRITAAEALKHP 280

Query: 323 YF 324
           + 
Sbjct: 281 WI 282


>3F3Z-A nrPDB
          Length = 277

 Score = 87.4 bits (215), Expect = 9e-18,   Method: Compositional matrix adjust.
 Identities = 78/294 (26%), Positives = 136/294 (46%), Gaps = 47/294 (15%)

Query: 39  YQLVRKLGRGKYSEVFEAINI-TNNEKVVVKILKPVKKK--KIKREIKILENLRGGPNII 95
           Y L   +GRG + EV  A+   T   +   KI K   +   + K+EI+I+++L   PNII
Sbjct: 11  YTLENTIGRGSWGEVKIAVQKGTRIRRAAKKIPKYFVEDVDRFKQEIEIMKSL-DHPNII 69

Query: 96  TLADIVKDPVSRTPALVFEHVNNTD-FKQLY--QTLTDYDIRFYMYEILKALDYCHSMGI 152
            L +  +D  +    LV E     + F+++   +   + D    M ++L A+ YCH + +
Sbjct: 70  RLYETFED--NTDIYLVMELCTGGELFERVVHKRVFRESDAARIMKDVLSAVAYCHKLNV 127

Query: 153 MHRDVKPHNVMI--DHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYD 210
            HRD+KP N +   D     L+LID+GLA  + PG+    +V + Y+  P++L    +Y 
Sbjct: 128 AHRDLKPENFLFLTDSPDSPLKLIDFGLAARFKPGKMMRTKVGTPYYVSPQVLEG--LYG 185

Query: 211 YSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFN 270
              D WS G M+  ++    PF    D+ + +++I +   T    D+++           
Sbjct: 186 PECDEWSAGVMMYVLLCGYPPFSAPTDS-EVMLKIREGTFTFPEKDWLN----------- 233

Query: 271 DILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324
                                 VSP+A   + +LL    + R+T+ +A+EH +F
Sbjct: 234 ----------------------VSPQAESLIRRLLTKSPKQRITSLQALEHEWF 265


>1TKI-A nrPDB
          Length = 321

 Score = 87.4 bits (215), Expect = 1e-17,   Method: Compositional matrix adjust.
 Identities = 71/297 (23%), Positives = 141/297 (47%), Gaps = 49/297 (16%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP--VKKKKIKREIKILENLRGGPNI 94
           + Y +   LGRG++  V   +  ++ +  + K +K     +  +K+EI IL N+    NI
Sbjct: 5   EKYMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVKGTDQVLVKKEISIL-NIARHRNI 63

Query: 95  ITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----LTDYDIRFYMYEILKALDYCHSM 150
           + L +  +        ++FE ++  D  +   T    L + +I  Y++++ +AL + HS 
Sbjct: 64  LHLHESFESM--EELVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCEALQFLHSH 121

Query: 151 GIMHRDVKPHNVMIDHEHRK---LRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQ 207
            I H D++P N++  ++ R+   +++I++G A    PG  + +   +  +  PE+   + 
Sbjct: 122 NIGHFDIRPENII--YQTRRSSTIKIIEFGQARQLKPGDNFRLLFTAPEYYAPEVH-QHD 178

Query: 208 MYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDP 267
           +   + DMWSLG ++  ++    PF    +   Q+  I  ++  E  +D         + 
Sbjct: 179 VVSTATDMWSLGTLVYVLLSGINPFL--AETNQQI--IENIMNAEYTFD---------EE 225

Query: 268 RFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324
            F +I                     S EA+DF+D+LL  + +SR+TA EA++HP+ 
Sbjct: 226 AFKEI---------------------SIEAMDFVDRLLVKERKSRMTASEALQHPWL 261


>5U6Y-A nrPDB
          Length = 461

 Score = 87.0 bits (214), Expect = 1e-17,   Method: Compositional matrix adjust.
 Identities = 77/299 (25%), Positives = 140/299 (46%), Gaps = 53/299 (17%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK-----KKKIKREIKILENLRGGPN 93
           YQL  +LG+G +S V   + +   ++   KI+   K      +K++RE +I   L+  PN
Sbjct: 2   YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKH-PN 60

Query: 94  IITLADIVKDPVSRTPALVFEHVNNTD-FKQLY--QTLTDYDIRFYMYEILKALDYCHSM 150
           I+ L D + +       L+F+ V   + F+ +   +  ++ D    + +IL+A+ +CH M
Sbjct: 61  IVRLHDSISEEGHHY--LIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQM 118

Query: 151 GIMHRDVKPHNVMIDHEHR--KLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLVDYQ 207
           G++HRD+KP N+++  + +   ++L D+GLA E     Q +     +  +  PE+L    
Sbjct: 119 GVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRK-D 177

Query: 208 MYDYSLDMWSLGCMLASMIFRKEPFF--HGHDNYDQLVRIAKVLGTEDLYDYIDKYNIEL 265
            Y   +D+W+ G +L  ++    PF+    H  Y Q+   A        YD+        
Sbjct: 178 PYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGA--------YDF-------- 221

Query: 266 DPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324
                          W+          V+PEA D ++K+L  +   R+TA EA++HP+ 
Sbjct: 222 -----------PSPEWD---------TVTPEAKDLINKMLTINPSKRITAAEALKHPWI 260


>2A27-A nrPDB
          Length = 321

 Score = 87.0 bits (214), Expect = 1e-17,   Method: Compositional matrix adjust.
 Identities = 83/320 (25%), Positives = 147/320 (45%), Gaps = 55/320 (17%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP---------VKKKKIKREIKILE 86
           +D Y +  +LG G+++ V +    +   +   K +K          V +++I+RE+ IL 
Sbjct: 11  EDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILR 70

Query: 87  NLRGGPNIITLADIVKDPVSRTPA-LVFEHVNNT---DFKQLYQTLTDYDIRFYMYEILK 142
            +    N+ITL D+ ++   RT   L+ E V+     DF    ++L++ +   ++ +IL 
Sbjct: 71  QVLH-HNVITLHDVYEN---RTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILD 126

Query: 143 ALDYCHSMGIMHRDVKPHNVMIDHEHR---KLRLIDWGLAEFYHPGQEYNVRVASRYFKG 199
            ++Y H+  I H D+KP N+M+  ++     ++LID+GLA     G E+     +  F  
Sbjct: 127 GVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVA 186

Query: 200 PELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYID 259
           PE +V+Y+      DMWS+G +   ++    PF  G    + L  I  V      YD+ +
Sbjct: 187 PE-IVNYEPLGLEADMWSIGVITYILLSGASPFL-GDTKQETLANITAV-----SYDFDE 239

Query: 260 KYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAM 319
           ++                         S+   L    A DF+ KLL  + + RLT +EA+
Sbjct: 240 EF------------------------FSQTSEL----AKDFIRKLLVKETRKRLTIQEAL 271

Query: 320 EHPYFYTVVKDQARMGSSSM 339
            HP+   V   QA +   S+
Sbjct: 272 RHPWITPVDNQQAMVRRESV 291


>2QNJ-A nrPDB
          Length = 328

 Score = 86.7 bits (213), Expect = 2e-17,   Method: Compositional matrix adjust.
 Identities = 53/203 (26%), Positives = 110/203 (54%), Gaps = 12/203 (5%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKI-----LKPVKKKKIKREIKILENLRGGP 92
           +Y+L++ +G+G +++V  A +I    +V +KI     L P   +K+ RE++I++ L   P
Sbjct: 13  NYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKIL-NHP 71

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNT---DFKQLYQTLTDYDIRFYMYEILKALDYCHS 149
           NI+ L ++++    +T  L+ E+ +     D+   +  + + + R    +I+ A+ YCH 
Sbjct: 72  NIVKLFEVIE--TEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQ 129

Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMY 209
             I+HRD+K  N+++D +   +++ D+G +  +  G + +    S  +  PEL    +  
Sbjct: 130 KRIVHRDLKAENLLLDADM-NIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYD 188

Query: 210 DYSLDMWSLGCMLASMIFRKEPF 232
              +D+WSLG +L +++    PF
Sbjct: 189 GPEVDVWSLGVILYTLVSGSLPF 211


>4UZD-A nrPDB
          Length = 287

 Score = 86.7 bits (213), Expect = 2e-17,   Method: Compositional matrix adjust.
 Identities = 67/255 (26%), Positives = 126/255 (49%), Gaps = 25/255 (9%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK------IKREIKILENLRG 90
           +D+++ R LG+GK+  V+ A    +   + +K+L   + +K      ++RE++I  +LR 
Sbjct: 8   EDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRH 67

Query: 91  GPNIITLADIVKDPVSRTPALVFEHVN-NTDFKQLYQTLTDYD---IRFYMYEILKALDY 146
            PNI+ L     D       L+ E+    T +++L Q L+ +D      Y+ E+  AL Y
Sbjct: 68  -PNILRLYGYFHDATR--VYLILEYAPLGTVYREL-QKLSKFDEQRTATYITELANALSY 123

Query: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDY 206
           CHS  ++HRD+KP N+++     +L++ D+G +  + P         +  +  PE +++ 
Sbjct: 124 CHSKRVIHRDIKPENLLLGSAG-ELKIADFGWS-VHAPSSRRTTLCGTLDYLPPE-MIEG 180

Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHG--HDNYDQLVRIAKVL------GTEDLYDYI 258
           +M+D  +D+WSLG +    +  K PF      + Y ++ R+          G  DL   +
Sbjct: 181 RMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRL 240

Query: 259 DKYNIELDPRFNDIL 273
            K+N    P   ++L
Sbjct: 241 LKHNPSQRPMLREVL 255


>5UNP-A nrPDB
          Length = 369

 Score = 86.7 bits (213), Expect = 2e-17,   Method: Compositional matrix adjust.
 Identities = 83/333 (24%), Positives = 157/333 (47%), Gaps = 44/333 (13%)

Query: 29  HVVEWGNQDDYQLVRKLGRGKYSEVFEAIN-ITNNEKVVVKILKPVKKKK--IKREIKIL 85
           HV +W  Q+ Y++V  LG G +  V + ++      +V +KI+K V+K K   + EI +L
Sbjct: 27  HVGDWL-QERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVL 85

Query: 86  ENL-RGGPNIITLADIVKDPVSRTP--ALVFEHVNNTDFKQL----YQTLTDYDIRFYMY 138
           E +    P+   L   + D         + FE +  + F  L    Y     + +R   +
Sbjct: 86  EKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAF 145

Query: 139 EILKALDYCHSMGIMHRDVKPHNVMI---DHE---------------HRKLRLIDWGLAE 180
           ++ +A+ + H   + H D+KP N++    D+E                  +R++D+G A 
Sbjct: 146 QLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSAT 205

Query: 181 FYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYD 240
           F H  + ++  V++R+++ PE++++   +    D+WS+GC++    +     F  HDN +
Sbjct: 206 FDH--EHHSTIVSTRHYRAPEVILELG-WSQPCDVWSIGCIIFEY-YVGFTLFQTHDNRE 261

Query: 241 QLVRIAKVLGT--EDLYDYIDK----YNIELDPRFNDILGRHSRKRWE---RFVHSENQH 291
            L  + ++LG     +     K    Y   LD   N   GR+ R+  +   R++ SE + 
Sbjct: 262 HLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEE 321

Query: 292 LVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324
               +  D ++ +L Y+   RLT  EA++HP+F
Sbjct: 322 --HHQLFDLIESMLEYEPAKRLTLGEALQHPFF 352


>2HAK-A nrPDB
          Length = 328

 Score = 86.3 bits (212), Expect = 2e-17,   Method: Compositional matrix adjust.
 Identities = 54/203 (26%), Positives = 109/203 (53%), Gaps = 12/203 (5%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKI-----LKPVKKKKIKREIKILENLRGGP 92
           +Y+L + +G+G +++V  A ++    +V VKI     L P   +K+ RE++I++ L   P
Sbjct: 16  NYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKIL-NHP 74

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNT---DFKQLYQTLTDYDIRFYMYEILKALDYCHS 149
           NI+ L ++++    +T  LV E+ +     D+   +  + + + R    +I+ A+ YCH 
Sbjct: 75  NIVKLFEVIE--TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQ 132

Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMY 209
             I+HRD+K  N+++D +   +++ D+G +  +  G + +    S  +  PEL    +  
Sbjct: 133 KYIVHRDLKAENLLLDGDM-NIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYD 191

Query: 210 DYSLDMWSLGCMLASMIFRKEPF 232
              +D+WSLG +L +++    PF
Sbjct: 192 GPEVDVWSLGVILYTLVSGSLPF 214


>3Q5I-A nrPDB
          Length = 504

 Score = 86.3 bits (212), Expect = 2e-17,   Method: Compositional matrix adjust.
 Identities = 86/354 (24%), Positives = 155/354 (43%), Gaps = 69/354 (19%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK----------------IKR 80
           + Y  VRKLG G Y EV        + +  +K++K  +  K                I  
Sbjct: 36  ESYFKVRKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYSDDNKNIEKFHEEIYN 95

Query: 81  EIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTD-FKQLYQ--TLTDYDIRFYM 137
           EI +L++L   PNII L D+ +D   +   LV E     + F+Q+       + D    M
Sbjct: 96  EISLLKSL-DHPNIIKLFDVFEDK--KYFYLVTEFYEGGELFEQIINRHKFDECDAANIM 152

Query: 138 YEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKL--RLIDWGLAEFYHPGQEYNVRVASR 195
            +IL  + Y H   I+HRD+KP N+++++++  L  +++D+GL+ F+    +   R+ + 
Sbjct: 153 KQILSGICYLHKHNIVHRDIKPENILLENKNSLLNIKIVDFGLSSFFSKDYKLRDRLGTA 212

Query: 196 YFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLY 255
           Y+  PE+L   + Y+   D+WS G ++  ++    P F G ++ D + ++ K        
Sbjct: 213 YYIAPEVLK--KKYNEKCDVWSCGVIMYILLCGYPP-FGGQNDQDIIKKVEK-------- 261

Query: 256 DYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTA 315
               KY  +    FND         W+          +S EA + +  +L YD+  R TA
Sbjct: 262 ---GKYYFD----FND---------WKN---------ISDEAKELIKLMLTYDYNKRCTA 296

Query: 316 REAMEHPYFYTVVKDQARMGSSSMPG---------GSTPVSSANMMSGISSVPT 360
            EA+   +      +  +    ++ G         GS  ++ A ++   S + T
Sbjct: 297 EEALNSRWIKKYANNINKSDQKTLCGALSNMRKFEGSQKLAQAAILFIGSKLTT 350


>6CMJ-A nrPDB
          Length = 321

 Score = 86.3 bits (212), Expect = 2e-17,   Method: Compositional matrix adjust.
 Identities = 63/218 (28%), Positives = 109/218 (50%), Gaps = 25/218 (11%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKR---------------- 80
           D Y L  ++G+G Y  V  A N  +N    +K+L   KKK I++                
Sbjct: 34  DQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLS--KKKLIRQAGGCIQPRGPIEQVYQ 91

Query: 81  EIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQL--YQTLTDYDIRFYMY 138
           EI IL+ L   PN++ L +++ DP      +VFE VN     ++   + L++   RFY  
Sbjct: 92  EIAILKKL-DHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQ 150

Query: 139 EILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYNVRVASRYF 197
           +++K ++Y H   I+HRD+KP N+++  E   +++ D+G++ EF       +  V +  F
Sbjct: 151 DLIKGIEYLHYQKIIHRDIKPSNLLVG-EDGHIKIADFGVSNEFKGSDALLSNTVGTPAF 209

Query: 198 KGPELLVDYQ--MYDYSLDMWSLGCMLASMIFRKEPFF 233
             PE L + +      +LD+W++G  L   +F + PF 
Sbjct: 210 MAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFM 247


>4FG9-A nrPDB
          Length = 320

 Score = 86.3 bits (212), Expect = 2e-17,   Method: Compositional matrix adjust.
 Identities = 78/300 (26%), Positives = 140/300 (46%), Gaps = 51/300 (17%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPV----KKKKIKREIKILENLRGG 91
           +D Y     LG G +SEV  A +    + V +K +       K+  ++ EI +L  ++  
Sbjct: 17  RDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMENEIAVLHKIKH- 75

Query: 92  PNIITLADIVKDPVSRTPALVFEHVNNTD-FKQLYQT--LTDYDIRFYMYEILKALDYCH 148
           PNI+ L DI +        L+ + V+  + F ++ +    T+ D    ++++L A+ Y H
Sbjct: 76  PNIVALDDIYES--GGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLH 133

Query: 149 SMGIMHRDVKPHNVM---IDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVD 205
            +GI+HRD+KP N++   +D E  K+ + D+GL++   PG   +    +  +  PE+L  
Sbjct: 134 DLGIVHRDLKPENLLYYSLD-EDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEVLAQ 192

Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIEL 265
            + Y  ++D WS+G +   ++    PF+  +D        AK      L++ I K   E 
Sbjct: 193 -KPYSKAVDCWSIGVIAYILLCGYPPFYDEND--------AK------LFEQILKAEYEF 237

Query: 266 D-PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324
           D P ++DI                     S  A DF+  L+  D + R T  +A++HP+ 
Sbjct: 238 DSPYWDDI---------------------SDSAKDFIRHLMEKDPEKRFTCEQALQHPWI 276


>3GUB-A nrPDB
          Length = 295

 Score = 86.3 bits (212), Expect = 2e-17,   Method: Compositional matrix adjust.
 Identities = 81/322 (25%), Positives = 148/322 (45%), Gaps = 54/322 (16%)

Query: 35  NQDDY-QLVRKLGRGKYSEVFEAINITNNEKVVVKILKP---------VKKKKIKREIKI 84
           N DDY     +LG G+++ V +    +   +   K +K          V ++ I+RE+ I
Sbjct: 8   NVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSI 67

Query: 85  LENLRGGPNIITLADIVKDPVSRTPALVFEHVNNT---DFKQLYQTLTDYDIRFYMYEIL 141
           L+ ++  PN+ITL ++ ++       L+ E V      DF    ++LT+ +   ++ +IL
Sbjct: 68  LKEIQH-PNVITLHEVYENKTDVI--LIGELVAGGELFDFLAEKESLTEEEATEFLKQIL 124

Query: 142 KALDYCHSMGIMHRDVKPHNVMIDHEHR---KLRLIDWGLAEFYHPGQEYNVRVASRYFK 198
             + Y HS+ I H D+KP N+M+   +    ++++ID+GLA     G E+     +  F 
Sbjct: 125 NGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFV 184

Query: 199 GPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYI 258
            PE +V+Y+      DMWS+G +   ++    PF  G    + L  ++ V      Y++ 
Sbjct: 185 APE-IVNYEPLGLEADMWSIGVITYILLSGASPFL-GDTKQETLANVSAV-----NYEFE 237

Query: 259 DKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREA 318
           D+Y       F++                      S  A DF+ +LL  D + R+T +++
Sbjct: 238 DEY-------FSN---------------------TSALAKDFIRRLLVKDPKKRMTIQDS 269

Query: 319 MEHPYFYTVVKDQARMGSSSMP 340
           ++HP+       QA   + S P
Sbjct: 270 LQHPWIKPKDTQQALSSAWSHP 291


>4CFF-A nrPDB
          Length = 571

 Score = 85.9 bits (211), Expect = 3e-17,   Method: Compositional matrix adjust.
 Identities = 61/203 (30%), Positives = 99/203 (48%), Gaps = 13/203 (6%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK------KIKREIKILENLRGGP 92
           Y L   LG G + +V    +     KV VKIL   K +      KIKREI+ L+  R  P
Sbjct: 35  YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH-P 93

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNT---DFKQLYQTLTDYDIRFYMYEILKALDYCHS 149
           +II L  ++  P      +V E+V+     D+   +  + + + R    +IL A+DYCH 
Sbjct: 94  HIIKLYQVISTPTDFF--MVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHR 151

Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMY 209
             ++HRD+KP NV++D  H   ++ D+GL+     G+       S  +  PE++      
Sbjct: 152 HMVVHRDLKPENVLLD-AHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYA 210

Query: 210 DYSLDMWSLGCMLASMIFRKEPF 232
              +D+WS G +L +++    PF
Sbjct: 211 GPEVDIWSCGVILYALLCGTLPF 233


>4PDS-A nrPDB
          Length = 347

 Score = 85.9 bits (211), Expect = 3e-17,   Method: Compositional matrix adjust.
 Identities = 78/308 (25%), Positives = 134/308 (43%), Gaps = 58/308 (18%)

Query: 38  DYQLVRKL-GRGKYSEVFEAINITNNEKVVVKILKPVK----KKKIKREIKILENLRGGP 92
           D+ ++ ++ G+G ++ V +AI  T  +   VKI+   K       + RE+++L+ L   P
Sbjct: 31  DFSIIDEVVGQGAFATVKKAIERTTGKTFSVKIISKRKVIGNMDGVTRELEVLQKLNH-P 89

Query: 93  NIITLADIVKDPVSRTPALVFEHVNN---TDFKQLYQTLTDYDIRFYMYEILKALDYCHS 149
            I+ L    +D  + +  +V E V+     DF   +  + +   R    +IL A+ Y HS
Sbjct: 90  RIVRLKGFYED--TESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHS 147

Query: 150 MGIMHRDVKPHNVMIDHEHRKL-RLIDWGLAEFYHPGQEYNVRVASRYFKGPELL----- 203
           MGI HRD+KP N++I+ +   L ++  +GLA+    G        +  +  PE++     
Sbjct: 148 MGISHRDLKPDNILIEQDDPVLVKITAFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDT 207

Query: 204 -------VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYD 256
                   +   Y   +DMWS+GC++  ++    PF       DQ            LY 
Sbjct: 208 SVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPF--SGSTQDQ------------LYK 253

Query: 257 YIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAR 316
            I + +    P                         +S EA DF+D LL+ D  +R TA 
Sbjct: 254 QIGRGSYHEGPL--------------------KDFRISEEARDFIDSLLQVDPNNRSTAA 293

Query: 317 EAMEHPYF 324
           +A+ HP+ 
Sbjct: 294 KALNHPWI 301


>3ORZ-A nrPDB
          Length = 316

 Score = 85.9 bits (211), Expect = 3e-17,   Method: Compositional matrix adjust.
 Identities = 79/311 (25%), Positives = 138/311 (44%), Gaps = 63/311 (20%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP---VKKKKI---KREIKILENLRG 90
           +D++  + LG G +S V  A  +  + +  +KIL+    +K+ K+    RE  ++  L  
Sbjct: 37  EDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRL-D 95

Query: 91  GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYD---IRFYMYEILKALDYC 147
            P  + L    +D       L   +  N +  +  + +  +D    RFY  EI+ AL+Y 
Sbjct: 96  HPFFVKLYFCFQDDEKLYFGL--SYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYL 153

Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEY---NVRVASRYFKGPELLV 204
           H  GI+HRD+KP N++++ E   +++ D+G A+   P  +    N  V +  +  PELL 
Sbjct: 154 HGKGIIHRDLKPENILLN-EDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLT 212

Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIE 264
           +      S D+W+LGC++  ++    PF  G    ++ +   K++  E  YD+ +K+   
Sbjct: 213 EKSACKSS-DLWALGCIIYQLVAGLPPFRAG----NEYLIFQKIIKLE--YDFPEKF--- 262

Query: 265 LDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAME---- 320
                                         P+A D ++KLL  D   RL   E ME    
Sbjct: 263 -----------------------------FPKARDLVEKLLVLDATKRLGCEE-MEGYGP 292

Query: 321 ---HPYFYTVV 328
              HP+F +V 
Sbjct: 293 LKAHPFFESVT 303


>2WO6-A nrPDB
          Length = 382

 Score = 85.9 bits (211), Expect = 3e-17,   Method: Compositional matrix adjust.
 Identities = 89/335 (26%), Positives = 162/335 (48%), Gaps = 59/335 (17%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK--KKIKREIKILENLRGGPNI 94
           D Y++   +G+G + +V +A +    E V +KI+K  K    + + E+++LE +      
Sbjct: 54  DRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTE 113

Query: 95  IT--LADIVKDPVSRT-PALVFEHVN--------NTDFKQLYQTLTDYDIRFYMYEILKA 143
           +   +  + +  + R    LVFE ++        NT+F+ +   LT    R +  ++  A
Sbjct: 114 MKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLT----RKFAQQMCTA 169

Query: 144 LDYCHS--MGIMHRDVKPHNVMIDHEHRK-LRLIDWGLAEFYHPGQEYNVRVASRYFKGP 200
           L +  +  + I+H D+KP N+++ +  R  ++++D+G +     GQ     + SR+++ P
Sbjct: 170 LLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSS--CQLGQRIYQYIQSRFYRSP 227

Query: 201 ELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGT--------- 251
           E+L+    YD ++DMWSLGC+L  M    EP F G +  DQ+ +I +VLG          
Sbjct: 228 EVLLGMP-YDLAIDMWSLGCILVEM-HTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQA 285

Query: 252 -------EDLYDYIDKYNI--------ELDP----RFNDILGRHSRKRWERFVHSENQHL 292
                  E L D    +N+        E  P    + ++ILG  +     R    E+ H 
Sbjct: 286 PKARKFFEKLPD--GTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRA-GESGHT 342

Query: 293 VSPEALDFLDKLLR---YDHQSRLTAREAMEHPYF 324
           V+ + L F D +LR   YD ++R+    A++H +F
Sbjct: 343 VA-DYLKFKDLILRMLDYDPKTRIQPYYALQHSFF 376


>3UTO-A nrPDB
          Length = 573

 Score = 85.5 bits (210), Expect = 3e-17,   Method: Compositional matrix adjust.
 Identities = 83/345 (24%), Positives = 149/345 (43%), Gaps = 61/345 (17%)

Query: 37  DDYQLVRKLGRGKYSEVFEAIN-ITNNEKVVVKILKP--VKKKKIKREIKILENLRGGPN 93
           D Y +  +LG G +  V       T N      ++ P    K+ +++EI+ +  LR  P 
Sbjct: 157 DHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKETVRKEIQTMSVLRH-PT 215

Query: 94  IITLADIVKDPVSRTPALVFEHVNNTD-FKQL---YQTLTDYDIRFYMYEILKALDYCHS 149
           ++ L D  +D       +++E ++  + F+++   +  +++ +   YM ++ K L + H 
Sbjct: 216 LVNLHDAFED--DNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMRQVCKGLCHMHE 273

Query: 150 MGIMHRDVKPHNVMIDHEH-RKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQM 208
              +H D+KP N+M   +   +L+LID+GL     P Q   V   +  F  PE + + + 
Sbjct: 274 NNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTTGTAEFAAPE-VAEGKP 332

Query: 209 YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPR 268
             Y  DMWS+G +   ++    PF  G +N D+ +R  K             +N++ D  
Sbjct: 333 VGYYTDMWSVGVLSYILLSGLSPF--GGENDDETLRNVKSC----------DWNMD-DSA 379

Query: 269 FNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVV 328
           F+ I                     S +  DF+ KLL  D  +R+T  +A+EHP+     
Sbjct: 380 FSGI---------------------SEDGKDFIRKLLLADPNTRMTIHQALEHPW----- 413

Query: 329 KDQARMGSSSMPGGSTPVSSANMMSGISSVPT-----PSPLGPLA 368
                +   + PG  + + S+       S+ T     P PL PL 
Sbjct: 414 -----LTPGNAPGRDSQIPSSRYTKIRDSIKTKYDAWPEPLPPLG 453


>5EZV-A nrPDB
          Length = 560

 Score = 85.5 bits (210), Expect = 3e-17,   Method: Compositional matrix adjust.
 Identities = 61/203 (30%), Positives = 99/203 (48%), Gaps = 13/203 (6%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK------KIKREIKILENLRGGP 92
           Y L   LG G + +V    +     KV VKIL   K +      KIKREI+ L+  R  P
Sbjct: 30  YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH-P 88

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNT---DFKQLYQTLTDYDIRFYMYEILKALDYCHS 149
           +II L  ++  P      +V E+V+     D+   +  + + + R    +IL A+DYCH 
Sbjct: 89  HIIKLYQVISTPTDFF--MVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHR 146

Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMY 209
             ++HRD+KP NV++D  H   ++ D+GL+     G+       S  +  PE++      
Sbjct: 147 HMVVHRDLKPENVLLD-AHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYA 205

Query: 210 DYSLDMWSLGCMLASMIFRKEPF 232
              +D+WS G +L +++    PF
Sbjct: 206 GPEVDIWSCGVILYALLCGTLPF 228


>5WAX-A nrPDB
          Length = 310

 Score = 85.5 bits (210), Expect = 4e-17,   Method: Compositional matrix adjust.
 Identities = 71/294 (24%), Positives = 134/294 (45%), Gaps = 41/294 (13%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK--KKIKREIKILENLRGGPNI 94
           D Y+LVR +G G +       N  + + V VK ++  +K  + ++REI    +LR  PNI
Sbjct: 11  DRYELVRDIGSGNFGVARLMRNRADGQLVAVKYIERGEKIDENVQREIINHRSLRH-PNI 69

Query: 95  ITLADIVKDPVSRTPALVFEHVNNTD-FKQLYQT--LTDYDIRFYMYEILKALDYCHSMG 151
           I   +++  P     A+V E+ +  + F+++      ++ + RF+  +++  + YCHSM 
Sbjct: 70  IRFKEVILTPTHL--AIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHSMQ 127

Query: 152 IMHRDVKPHNVMIDHEHR-KLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYD 210
           + HRD+K  N ++D     +L++ D+G ++      +    V +  +  PE+L+  +   
Sbjct: 128 VCHRDLKLENTLLDGSTAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDG 187

Query: 211 YSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFN 270
              D+WS G  L  M+    PF    +  +    I ++LG +        Y+I       
Sbjct: 188 KVADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRILGVQ--------YSI------- 232

Query: 271 DILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324
                        +VH      +SPE  D + ++   +  +R+T  E   HP+F
Sbjct: 233 -----------PDYVH------ISPECQDLISRIFVANPATRITIPEIRNHPWF 269


>6C9D-A nrPDB
          Length = 459

 Score = 85.5 bits (210), Expect = 4e-17,   Method: Compositional matrix adjust.
 Identities = 54/203 (26%), Positives = 109/203 (53%), Gaps = 12/203 (5%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKI-----LKPVKKKKIKREIKILENLRGGP 92
           +Y+L + +G+G +++V  A ++    +V VKI     L P   +K+ RE++I++ L   P
Sbjct: 22  NYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKIL-NHP 80

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNT---DFKQLYQTLTDYDIRFYMYEILKALDYCHS 149
           NI+ L ++++    +T  LV E+ +     D+   +  + + + R    +I+ A+ YCH 
Sbjct: 81  NIVKLFEVIE--TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQ 138

Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMY 209
             I+HRD+K  N+++D +   +++ D+G +  +  G + +    S  +  PEL    +  
Sbjct: 139 KYIVHRDLKAENLLLDGDM-NIKIADFGFSNEFTVGNKLDEFCGSPPYAAPELFQGKKYD 197

Query: 210 DYSLDMWSLGCMLASMIFRKEPF 232
              +D+WSLG +L +++    PF
Sbjct: 198 GPEVDVWSLGVILYTLVSGSLPF 220


>1KOA-A nrPDB
          Length = 491

 Score = 85.1 bits (209), Expect = 4e-17,   Method: Compositional matrix adjust.
 Identities = 83/345 (24%), Positives = 149/345 (43%), Gaps = 61/345 (17%)

Query: 37  DDYQLVRKLGRGKYSEVFEAIN-ITNNEKVVVKILKP--VKKKKIKREIKILENLRGGPN 93
           D Y +  +LG G +  V       T N      ++ P    K+ +++EI+ +  LR  P 
Sbjct: 51  DHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKETVRKEIQTMSVLRH-PT 109

Query: 94  IITLADIVKDPVSRTPALVFEHVNNTD-FKQL---YQTLTDYDIRFYMYEILKALDYCHS 149
           ++ L D  +D       +++E ++  + F+++   +  +++ +   YM ++ K L + H 
Sbjct: 110 LVNLHDAFED--DNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMRQVCKGLCHMHE 167

Query: 150 MGIMHRDVKPHNVMIDHEH-RKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQM 208
              +H D+KP N+M   +   +L+LID+GL     P Q   V   +  F  PE + + + 
Sbjct: 168 NNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTTGTAEFAAPE-VAEGKP 226

Query: 209 YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPR 268
             Y  DMWS+G +   ++    PF  G +N D+ +R  K             +N++ D  
Sbjct: 227 VGYYTDMWSVGVLSYILLSGLSPF--GGENDDETLRNVKSC----------DWNMD-DSA 273

Query: 269 FNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVV 328
           F+ I                     S +  DF+ KLL  D  +R+T  +A+EHP+     
Sbjct: 274 FSGI---------------------SEDGKDFIRKLLLADPNTRMTIHQALEHPW----- 307

Query: 329 KDQARMGSSSMPGGSTPVSSANMMSGISSVPT-----PSPLGPLA 368
                +   + PG  + + S+       S+ T     P PL PL 
Sbjct: 308 -----LTPGNAPGRDSQIPSSRYTKIRDSIKTKYDAWPEPLPPLG 347


>5KZ7-A nrPDB
          Length = 346

 Score = 84.7 bits (208), Expect = 7e-17,   Method: Compositional matrix adjust.
 Identities = 64/267 (23%), Positives = 136/267 (50%), Gaps = 20/267 (7%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK-----KKIKREIKILENLRGGP 92
           +Y+L++ +G+G +++V  A +I   ++V VKI+   +      +K+ RE++I++ L   P
Sbjct: 34  NYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVL-NHP 92

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNT---DFKQLYQTLTDYDIRFYMYEILKALDYCHS 149
           NI+ L ++++    +T  LV E+ +     D+   +  + + + R    +I+ A+ YCH 
Sbjct: 93  NIVKLFEVIE--TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQ 150

Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMY 209
             I+HRD+K  N+++D +   +++ D+G +  +  G + +    S  +  PEL    +  
Sbjct: 151 KFIVHRDLKAENLLLDAD-MNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYD 209

Query: 210 DYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAK------VLGTEDLYDYIDKYNI 263
              +D+WSLG +L +++    P F G +  +   R+ +         + D  + + K+ I
Sbjct: 210 GPEVDVWSLGVILYTLVSGSLP-FDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLI 268

Query: 264 ELDPRFNDILGRHSRKRWERFVHSENQ 290
            L+P     L +  + RW    H +++
Sbjct: 269 -LNPSKRGTLEQIMKDRWMNVGHEDDE 294


>4YZB-A nrPDB
          Length = 491

 Score = 84.3 bits (207), Expect = 8e-17,   Method: Compositional matrix adjust.
 Identities = 77/345 (22%), Positives = 153/345 (44%), Gaps = 65/345 (18%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGG----- 91
           D Y+  R LG+G + EV    +    ++  VK+   + K+++K++      L+       
Sbjct: 30  DRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKV---ISKRQVKQKTDKELLLKEVELLKK 86

Query: 92  ---PNIITLADIVKDP-----VSR--TPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEIL 141
              PNI+ L +  +D      V+   T   +F+ + +       +  ++ D    + ++L
Sbjct: 87  LDHPNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISR------KRFSEVDAARIIRQVL 140

Query: 142 KALDYCHSMGIMHRDVKPHNVMIDHEHR--KLRLIDWGLAEFYHPGQEYNVRVASRYFKG 199
             + Y H   I+HRD+KP N++++++ +   +R+ID+GL+  +   ++   ++ + Y+  
Sbjct: 141 SGITYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIA 200

Query: 200 PELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYID 259
           PE+L  +  YD   D+WS G +L  ++    P F+G + +D L ++ K   T DL     
Sbjct: 201 PEVL--HGTYDEKCDVWSTGVILY-ILLSGCPPFNGANEFDILKKVEKGKFTFDL----- 252

Query: 260 KYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAM 319
                               +W++         VS  A D + K+L Y    R++AR+A+
Sbjct: 253 -------------------PQWKK---------VSEPAKDLIRKMLAYVPTMRISARDAL 284

Query: 320 EHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPL 364
           EH +  T     A   S  +P   + + +     G   +   + L
Sbjct: 285 EHEWLKTT---DAATDSIDVPSLESTILNIRQFQGTQKLAAAALL 326


>5FG8-A nrPDB
          Length = 285

 Score = 84.3 bits (207), Expect = 8e-17,   Method: Compositional matrix adjust.
 Identities = 75/301 (24%), Positives = 142/301 (47%), Gaps = 53/301 (17%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK-----KKIKREIKILENLRGG 91
           D+Y +  +LG+G +S V   +  +   +   KI+   K      +K++RE +I   L   
Sbjct: 14  DNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHH- 72

Query: 92  PNIITLADIVKDPVSRTPALVFEHVNNTD-FKQLY--QTLTDYDIRFYMYEILKALDYCH 148
           PNI+ L D +++       LVF+ V   + F+ +   +  ++ D    + +IL+++++CH
Sbjct: 73  PNIVRLHDSIQE--ENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCH 130

Query: 149 SMGIMHRDVKPHNVMIDHEHR--KLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLVD 205
             G++HRD+KP N+++  + +   ++L D+GLA E     Q +     +  +  PE+L  
Sbjct: 131 QNGVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVL-K 189

Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFF--HGHDNYDQLVRIAKVLGTEDLYDYIDKYNI 263
            + Y  S+D+W+ G +L  ++    PF+    H  Y Q+   A        YDY      
Sbjct: 190 KEPYGKSVDIWACGVILYILLVGYPPFWDEDQHRLYSQIKAGA--------YDY------ 235

Query: 264 ELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323
                            W+          V+PEA + ++++L  +   R+TA EA++HP+
Sbjct: 236 -------------PSPEWD---------TVTPEAKNLINQMLTVNPNKRITAAEALKHPW 273

Query: 324 F 324
            
Sbjct: 274 I 274


>4CZT-A nrPDB
          Length = 464

 Score = 84.0 bits (206), Expect = 9e-17,   Method: Compositional matrix adjust.
 Identities = 60/207 (28%), Positives = 111/207 (53%), Gaps = 18/207 (8%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKIL---KPVKKK---KIKREIKILENLRGGP 92
           Y+L R LG G +++V  A N+ N + V +K++   K +K K   +IKREI  ++ ++  P
Sbjct: 13  YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH-P 71

Query: 93  NIITLADIVKDPVSRTPA-LVFEHVNNTD-FKQLYQT--LTDYDIRFYMYEILKALDYCH 148
           N+I + +++    S+T    V E V   + F ++     L + + R Y  +++ A+DYCH
Sbjct: 72  NVIRMFEVM---ASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCH 128

Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE---YNVRVASRYFKGPELLVD 205
           S G+ HRD+KP N+++D  +  L++ D+GL+      +E    +    +  +  PE++ +
Sbjct: 129 SRGVYHRDLKPENLLLDA-NGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINN 187

Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPF 232
                   D+WS G +L  ++    PF
Sbjct: 188 KGYDGAKADLWSCGVILFVLMAGYLPF 214


>3SOA-A nrPDB
          Length = 444

 Score = 84.0 bits (206), Expect = 1e-16,   Method: Compositional matrix adjust.
 Identities = 75/301 (24%), Positives = 141/301 (46%), Gaps = 53/301 (17%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK-----KKKIKREIKILENLRGG 91
           ++YQL  +LG+G +S V   + +   ++    I+   K      +K++RE +I   L+  
Sbjct: 11  EEYQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDHQKLEREARICRLLKH- 69

Query: 92  PNIITLADIVKDPVSRTPALVFEHVNNTD-FKQLY--QTLTDYDIRFYMYEILKALDYCH 148
           PNI+ L D + +       L+F+ V   + F+ +   +  ++ D    + +IL+A+ +CH
Sbjct: 70  PNIVRLHDSISEEGHHY--LIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCH 127

Query: 149 SMGIMHRDVKPHNVMIDHEHR--KLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLVD 205
            MG++HR++KP N+++  + +   ++L D+GLA E     Q +     +  +  PE+L  
Sbjct: 128 QMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRK 187

Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFF--HGHDNYDQLVRIAKVLGTEDLYDYIDKYNI 263
              Y   +D+W+ G +L  ++    PF+    H  Y Q+   A        YD+      
Sbjct: 188 -DPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGA--------YDF------ 232

Query: 264 ELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323
                            W+          V+PEA D ++K+L  +   R+TA EA++HP+
Sbjct: 233 -------------PSPEWD---------TVTPEAKDLINKMLTINPSKRITAAEALKHPW 270

Query: 324 F 324
            
Sbjct: 271 I 271


>4RLP-A nrPDB
          Length = 288

 Score = 84.0 bits (206), Expect = 1e-16,   Method: Compositional matrix adjust.
 Identities = 80/307 (26%), Positives = 135/307 (43%), Gaps = 62/307 (20%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIIT 96
           + ++L+R LG+G Y +VF+   +T      +  +K +KK  I R  K   + +   NI+ 
Sbjct: 5   ECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNIL- 63

Query: 97  LADIVKDP----------VSRTPALVFEHVNNTD-FKQLYQ--TLTDYDIRFYMYEILKA 143
             + VK P                L+ E+++  + F QL +     +    FY+ EI  A
Sbjct: 64  --EEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMA 121

Query: 144 LDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPEL 202
           L + H  GI++RD+KP N+M++H+   ++L D+GL  E  H G   +    +  +  PE+
Sbjct: 122 LGHLHQKGIIYRDLKPENIMLNHQGH-VKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEI 180

Query: 203 LVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYN 262
           L+    ++ ++D WSLG ++  M+    PF    +N  + +            D I K  
Sbjct: 181 LMR-SGHNRAVDWWSLGALMYDMLTGAPPF--TGENRKKTI------------DKILKCK 225

Query: 263 IELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT-----ARE 317
           + L P                         ++ EA D L KLL+ +  SRL      A E
Sbjct: 226 LNLPP------------------------YLTQEARDLLKKLLKRNAASRLGAGPGDAGE 261

Query: 318 AMEHPYF 324
              HP+F
Sbjct: 262 VQAHPFF 268


>3BHH-A nrPDB
          Length = 295

 Score = 83.6 bits (205), Expect = 1e-16,   Method: Compositional matrix adjust.
 Identities = 75/300 (25%), Positives = 140/300 (46%), Gaps = 53/300 (17%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK-----KKKIKREIKILENLRGG 91
           D+YQL   +G+G +S V   + +    +   KI+   K      +K++RE +I   L+  
Sbjct: 4   DEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHS 63

Query: 92  PNIITLADIVKDPVSRTPALVFEHVNNTD-FKQLY--QTLTDYDIRFYMYEILKALDYCH 148
            NI+ L D + +       LVF+ V   + F+ +   +  ++ D    + +IL+A+ +CH
Sbjct: 64  -NIVRLHDSISEEGFHY--LVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCH 120

Query: 149 SMGIMHRDVKPHNVMIDHEHR--KLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLVD 205
            MG++HRD+KP N+++  + +   ++L D+GLA E     Q +     +  +  PE+L  
Sbjct: 121 QMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRK 180

Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFF--HGHDNYDQLVRIAKVLGTEDLYDYIDKYNI 263
            + Y   +D+W+ G +L  ++    PF+    H  Y Q+   A        YD+      
Sbjct: 181 -EAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGA--------YDF------ 225

Query: 264 ELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323
                            W+          V+PEA + ++++L  +   R+TA EA++HP+
Sbjct: 226 -------------PSPEWDT---------VTPEAKNLINQMLTINPAKRITAHEALKHPW 263


>4L42-A nrPDB
          Length = 346

 Score = 83.6 bits (205), Expect = 1e-16,   Method: Compositional matrix adjust.
 Identities = 80/305 (26%), Positives = 134/305 (43%), Gaps = 62/305 (20%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLA 98
           ++L+R LG+G Y +VF+   +T      +  +K +KK  I R  K   + +   NI+   
Sbjct: 20  FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNIL--- 76

Query: 99  DIVKDP----------VSRTPALVFEHVNNTD-FKQLYQ--TLTDYDIRFYMYEILKALD 145
           + VK P                L+ E+++  + F QL +     +    FY+ EI  AL 
Sbjct: 77  EEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALG 136

Query: 146 YCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLV 204
           + H  GI++RD+KP N+M++H+   ++L D+GL  E  H G   +    +  +  PE+L+
Sbjct: 137 HLHQKGIIYRDLKPENIMLNHQGH-VKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILM 195

Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIE 264
               ++ ++D WSLG ++  M+    PF    +N  + +            D I K  + 
Sbjct: 196 -RSGHNRAVDWWSLGALMYDMLTGAPPF--TGENRKKTI------------DKILKCKLN 240

Query: 265 LDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT-----AREAM 319
           L P                         ++ EA D L KLL+ +  SRL      A E  
Sbjct: 241 LPP------------------------YLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQ 276

Query: 320 EHPYF 324
            HP+F
Sbjct: 277 AHPFF 281


>2BDW-A nrPDB
          Length = 362

 Score = 83.2 bits (204), Expect = 2e-16,   Method: Compositional matrix adjust.
 Identities = 73/301 (24%), Positives = 141/301 (46%), Gaps = 54/301 (17%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK-----KKIKREIKILENLRGG 91
           D+Y +  +LG+G +S V   ++ T   +   KI+   K      +K++RE +I   L+  
Sbjct: 29  DNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQH- 87

Query: 92  PNIITLADIVKDPVSRTPALVFEHVNNTDF------KQLYQTLTDYDIRFYMYEILKALD 145
           PNI+ L D +++       LVF+ V   +       ++ Y   ++ D    + +IL+++ 
Sbjct: 88  PNIVRLHDSIQEESFHY--LVFDLVTGGELFEDIVAREFY---SEADASHCIQQILESIA 142

Query: 146 YCHSMGIMHRDVKPHNVMIDHEHR--KLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELL 203
           YCHS GI+HR++KP N+++  + +   ++L D+GLA   +  + ++    +  +  PE+L
Sbjct: 143 YCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVL 202

Query: 204 VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNI 263
                Y   +D+W+ G +L  ++    PF+    + DQ    A++      YDY      
Sbjct: 203 -KKDPYSKPVDIWACGVILYILLVGYPPFW----DEDQHRLYAQI--KAGAYDY------ 249

Query: 264 ELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323
                            W+          V+PEA   +D +L  + + R+TA +A++ P+
Sbjct: 250 -------------PSPEWD---------TVTPEAKSLIDSMLTVNPKKRITADQALKVPW 287

Query: 324 F 324
            
Sbjct: 288 I 288


>2JC6-A nrPDB
          Length = 334

 Score = 83.2 bits (204), Expect = 2e-16,   Method: Compositional matrix adjust.
 Identities = 77/296 (26%), Positives = 132/296 (44%), Gaps = 49/296 (16%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKIL--KPVKKKK--IKREIKILENLRGGPNI 94
           ++    LG G +SEV  A      +   VK +  K +K K+  I+ EI +L  ++   NI
Sbjct: 24  FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKH-ENI 82

Query: 95  ITLADIVKDPVSRTPALVFEHVNNTD-FKQLYQT--LTDYDIRFYMYEILKALDYCHSMG 151
           + L DI + P      LV + V+  + F ++ +    T+ D    + ++L A+ Y H MG
Sbjct: 83  VALEDIYESP--NHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMG 140

Query: 152 IMHRDVKPHNVMI--DHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMY 209
           I+HRD+KP N++     E  K+ + D+GL++    G   +    +  +  PE+L   + Y
Sbjct: 141 IVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQ-KPY 199

Query: 210 DYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD-PR 268
             ++D WS+G +   ++    PF+  +D+               L++ I K   E D P 
Sbjct: 200 SKAVDCWSIGVIAYILLCGYPPFYDENDS--------------KLFEQILKAEYEFDSPY 245

Query: 269 FNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324
           ++DI                     S  A DF+  L+  D   R T  +A  HP+ 
Sbjct: 246 WDDI---------------------SDSAKDFIRNLMEKDPNKRYTCEQAARHPWI 280


>4RGJ-A nrPDB
          Length = 520

 Score = 83.2 bits (204), Expect = 2e-16,   Method: Compositional matrix adjust.
 Identities = 75/304 (24%), Positives = 147/304 (48%), Gaps = 59/304 (19%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL--KPVKKKKIK----REIKILENLRG 90
           + Y+ ++ LG+G + EV  + +     +  +K++  K VK+K  K    RE+++L+ L  
Sbjct: 60  EQYKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKESLLREVELLKML-D 118

Query: 91  GPNIITLADIVKDP-----VSR--TPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKA 143
             NI+ L +  +D      VS   T   +F+ +     K+ Y+     D    + +IL  
Sbjct: 119 HINIMKLYEFFEDNNYYYLVSDVYTGGELFDEI--ISRKRFYEI----DAARIIKQILSG 172

Query: 144 LDYCHSMGIMHRDVKPHNVMIDHEHRK---LRLIDWGLAEFYHPGQEYNVRVASRYFKGP 200
           + Y H   ++HRD+KP N++++ ++++   +++ID+GL+  +   ++   ++ + Y+  P
Sbjct: 173 ITYMHKNNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHFEYSKKMKDKIGTAYYIAP 232

Query: 201 ELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDK 260
           ++L  +  YD   D+WS G +L  ++    P F+G + YD L ++              K
Sbjct: 233 DVL--HGTYDEKCDIWSCGVILY-ILLSGCPPFNGSNEYDILKKVEA-----------GK 278

Query: 261 YNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAME 320
           Y  +L P+F  I                     S +A D + K+L Y    R++AR+A+E
Sbjct: 279 YTFDL-PQFKKI---------------------SDKAKDLIKKMLMYTSAVRISARDALE 316

Query: 321 HPYF 324
           H + 
Sbjct: 317 HEWI 320


>2YZA-A nrPDB
          Length = 276

 Score = 82.8 bits (203), Expect = 3e-16,   Method: Compositional matrix adjust.
 Identities = 61/203 (30%), Positives = 99/203 (48%), Gaps = 13/203 (6%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK------KIKREIKILENLRGGP 92
           Y L   LG G + +V    +     KV VKIL   K +      KIKREI+ L+  R  P
Sbjct: 13  YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH-P 71

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNT---DFKQLYQTLTDYDIRFYMYEILKALDYCHS 149
           +II L  ++  P      +V E+V+     D+   +  + + + R    +IL A+DYCH 
Sbjct: 72  HIIKLYQVISTPTDFF--MVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHR 129

Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMY 209
             ++HRD+KP NV++D  H   ++ D+GL+     G+       S  +  PE++      
Sbjct: 130 HMVVHRDLKPENVLLD-AHMNAKIADFGLSNMMSDGEFLRDSCGSPNYAAPEVISGRLYA 188

Query: 210 DYSLDMWSLGCMLASMIFRKEPF 232
              +D+WS G +L +++    PF
Sbjct: 189 GPEVDIWSCGVILYALLCGTLPF 211


>4D2V-A nrPDB
          Length = 356

 Score = 82.4 bits (202), Expect = 3e-16,   Method: Compositional matrix adjust.
 Identities = 71/295 (24%), Positives = 134/295 (45%), Gaps = 51/295 (17%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP----VKKKKIKREIKILENLRGGPNI 94
           Y+L   +G G +++V  A +I   E V +KI+          +IK EI+ L+NLR   +I
Sbjct: 31  YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNLRH-QHI 89

Query: 95  ITLADIVKDPVSRTPALVFEHVNNT---DFKQLYQTLTDYDIRFYMYEILKALDYCHSMG 151
             L  +++   +    +V E+       D+      L++ + R    +I+ A+ Y HS G
Sbjct: 90  CQLYHVLE--TANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQG 147

Query: 152 IMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVR--VASRYFKGPELLVDYQMY 209
             HRD+KP N++ D E+ KL+LID+GL       ++Y+++    +  +  PEL+      
Sbjct: 148 YAHRDLKPENLLFD-EYHKLKLIDFGLCAKPKGNKDYHLQACCGALAYAAPELIQGKSYL 206

Query: 210 DYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRF 269
               D+WS+G +L  ++    PF    D+      +AK++                    
Sbjct: 207 GSEADVWSMGILLYVLMCGFLPF----DDDTAAALVAKIMR------------------- 243

Query: 270 NDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324
               G++   +W           +SP ++  L ++L+ D + R++ +  + HP+ 
Sbjct: 244 ----GKYDVPKW-----------LSPSSILLLQQMLQVDPKKRISMKNLLNHPWI 283


>3RAW-A nrPDB
          Length = 381

 Score = 82.4 bits (202), Expect = 3e-16,   Method: Compositional matrix adjust.
 Identities = 82/343 (23%), Positives = 156/343 (45%), Gaps = 52/343 (15%)

Query: 25  DYESHVV----EWGNQDDYQLVRKLGRGKYSEVFEAIN-ITNNEKVVVKILKPVKK--KK 77
           D E H+V    +W  Q+ Y++V  LG G + +V E ++      +V +KI++ V K  + 
Sbjct: 36  DKEGHLVCRIGDWL-QERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREA 94

Query: 78  IKREIKILENLRGGPN-----IITLADIVKDPVSRTPALVFEHVNNTDFKQL----YQTL 128
            + EI +L+ ++          + ++D           + FE +    F+ L    +Q  
Sbjct: 95  ARLEINVLKKIKEKDKENKFLCVLMSDWFN--FHGHMCIAFELLGKNTFEFLKENNFQPY 152

Query: 129 TDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVM--------IDHEHR----------K 170
               +R   Y++  AL + H   + H D+KP N++        + +EH+           
Sbjct: 153 PLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTS 212

Query: 171 LRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKE 230
           +R+ D+G A F H  + +   VA+R+++ PE++++   +    D+WS+GC+L    +R  
Sbjct: 213 IRVADFGSATFDH--EHHTTIVATRHYRPPEVILELG-WAQPCDVWSIGCILFEY-YRGF 268

Query: 231 PFFHGHDNYDQLVRIAKVLG--------TEDLYDYIDKYNIELDPRFNDILGRHSRKRWE 282
             F  H+N + LV + K+LG              Y  K  +  D   +D  GR+ ++  +
Sbjct: 269 TLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSD--GRYVKENCK 326

Query: 283 RF-VHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324
               +     L   +  D + ++L +D   R+T  EA+ HP+F
Sbjct: 327 PLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFF 369


>3KK8-A nrPDB
          Length = 284

 Score = 82.0 bits (201), Expect = 4e-16,   Method: Compositional matrix adjust.
 Identities = 73/298 (24%), Positives = 142/298 (47%), Gaps = 48/298 (16%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK-----KKIKREIKILENLRGG 91
           D+Y +  +LG+G +S V   ++ T   +   KI+   K      +K++RE +I   L+  
Sbjct: 6   DNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQH- 64

Query: 92  PNIITLADIVKDPVSRTPALVFEHVNNTD-FKQLY--QTLTDYDIRFYMYEILKALDYCH 148
           PNI+ L D +++       LVF+ V   + F+ +   +  ++ D    + +IL+++ YCH
Sbjct: 65  PNIVRLHDSIQEESFHY--LVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCH 122

Query: 149 SMGIMHRDVKPHNVMIDHEHR--KLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDY 206
           S GI+HR++KP N+++  + +   ++L D+GLA   +  + ++    +  +  PE+L   
Sbjct: 123 SNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVL-KK 181

Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 266
             Y   +D+W+ G +L  ++    PF+    + DQ    A++      YDY         
Sbjct: 182 DPYSKPVDIWACGVILYILLVGYPPFW----DEDQHRLYAQIKAGA--YDY--------- 226

Query: 267 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324
                         W+          V+PEA   +D +L  + + R+TA +A++ P+ 
Sbjct: 227 ----------PSPEWDT---------VTPEAKSLIDSMLTVNPKKRITADQALKVPWI 265


>5X8I-B nrPDB
          Length = 346

 Score = 81.6 bits (200), Expect = 5e-16,   Method: Compositional matrix adjust.
 Identities = 81/335 (24%), Positives = 149/335 (44%), Gaps = 67/335 (20%)

Query: 39  YQLVRKLGRGKYSEVFEAIN-ITNNEKVVVKILKPVKK--KKIKREIKILENLRGGPNII 95
           Y++V  LG G + +V E I+       V VKI+K V +  +  + EI++LE+L       
Sbjct: 15  YEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLN------ 68

Query: 96  TLADIVKDPVS--RTPALV--FEHVNNTDFKQLYQTLTDYD--------------IRFYM 137
                  DP S  R   ++  FEH  +         L+ YD              IR   
Sbjct: 69  -----TTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMA 123

Query: 138 YEILKALDYCHSMGIMHRDVKPHNVM-------------IDHEHRKL-----RLIDWGLA 179
           Y+I K++++ HS  + H D+KP N++             I  + R L     +++D+G A
Sbjct: 124 YQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSA 183

Query: 180 EFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNY 239
            +    + ++  V++R+++ PE+++    +    D+WS+GC+L    +     F  HD+ 
Sbjct: 184 TY--DDEHHSTLVSTRHYRAPEVILALG-WSQPCDVWSIGCILIEY-YLGFTVFPTHDSK 239

Query: 240 DQLVRIAKVLG----------TEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSEN 289
           + L  + ++LG           +  Y + D+ + +        + R  +   E  +  + 
Sbjct: 240 EHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQDV 299

Query: 290 QHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324
           +H       D + K+L YD   R+T REA++HP+F
Sbjct: 300 EH---ERLFDLIQKMLEYDPAKRITLREALKHPFF 331


>4WNO-A nrPDB
          Length = 287

 Score = 81.6 bits (200), Expect = 5e-16,   Method: Compositional matrix adjust.
 Identities = 58/212 (27%), Positives = 109/212 (51%), Gaps = 22/212 (10%)

Query: 39  YQLVRK--LGRGKYSEVFEAIN-ITNNEKVVVKIL--KPVKKKK--IKREIKILENLRGG 91
           ++  RK  +G G ++ VF+  +   ++ +V VK +  K + K +  + +EIKIL+ L+  
Sbjct: 18  FEFSRKDLIGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKH- 76

Query: 92  PNIITLADIVKDPVSRTPALVFEHVNN---TDFKQLYQTLTDYDIRFYMYEILKALDYCH 148
            NI+ L D     ++ +  LV E+ N     D+    +TL++  IR ++ +I  A+   H
Sbjct: 77  ENIVALYDF--QEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLH 134

Query: 149 SMGIMHRDVKPHNVMIDH--------EHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGP 200
           S GI+HRD+KP N+++ +           ++++ D+G A +            S  +  P
Sbjct: 135 SKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAP 194

Query: 201 ELLVDYQMYDYSLDMWSLGCMLASMIFRKEPF 232
           E+++  Q YD   D+WS+G ++   +  K PF
Sbjct: 195 EVIMS-QHYDGKADLWSIGTIVYQCLTGKAPF 225


>2W4O-A nrPDB
          Length = 349

 Score = 81.6 bits (200), Expect = 5e-16,   Method: Compositional matrix adjust.
 Identities = 79/293 (26%), Positives = 135/293 (46%), Gaps = 43/293 (14%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK-PVKKKKIKREIKILENLRGGPNII 95
           D +++  +LGRG  S V+        +   +K+LK  V KK ++ EI +L  L   PNII
Sbjct: 53  DFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKIVRTEIGVLLRL-SHPNII 111

Query: 96  TLADIVKDPVSRTPALVFEHVNNTD-FKQLYQT--LTDYDIRFYMYEILKALDYCHSMGI 152
            L +I + P   +  LV E V   + F ++ +    ++ D    + +IL+A+ Y H  GI
Sbjct: 112 KLKEIFETPTEIS--LVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGI 169

Query: 153 MHRDVKPHNVM--IDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYD 210
           +HRD+KP N++         L++ D+GL++             +  +  PE+L     Y 
Sbjct: 170 VHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCA-YG 228

Query: 211 YSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFN 270
             +DMWS+G +   ++   EPF+   +  DQ +   ++L  E  Y +I  +         
Sbjct: 229 PEVDMWSVGIITYILLCGFEPFY--DERGDQFM-FRRILNCE--YYFISPW--------- 274

Query: 271 DILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323
                     W+          VS  A D + KL+  D + RLT  +A++HP+
Sbjct: 275 ----------WDE---------VSLNAKDLVRKLIVLDPKKRLTTFQALQHPW 308


>3H4J-B nrPDB
          Length = 336

 Score = 81.6 bits (200), Expect = 5e-16,   Method: Compositional matrix adjust.
 Identities = 56/202 (27%), Positives = 104/202 (51%), Gaps = 12/202 (5%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKIL-KPVKKK-----KIKREIKILENLRGGP 92
           Y +   LG G + +V  A +    +KV +K + + + KK     +++REI  L+ LR  P
Sbjct: 11  YIIRETLGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREISYLKLLRH-P 69

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT--LTDYDIRFYMYEILKALDYCHSM 150
           +II L D++  P      +V E+     F  + +   +T+ + R +  +I+ A++YCH  
Sbjct: 70  HIIKLYDVITTPTD--IVMVIEYAGGELFDYIVEKKRMTEDEGRRFFQQIICAIEYCHRH 127

Query: 151 GIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYD 210
            I+HRD+KP N+++D ++  +++ D+GL+     G        S  +  PE++       
Sbjct: 128 KIVHRDLKPENLLLD-DNLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVINGKLYAG 186

Query: 211 YSLDMWSLGCMLASMIFRKEPF 232
             +D+WS G +L  M+  + PF
Sbjct: 187 PEVDVWSCGIVLYVMLVGRLPF 208


>1PHK-A nrPDB
          Length = 298

 Score = 80.9 bits (198), Expect = 9e-16,   Method: Compositional matrix adjust.
 Identities = 78/327 (23%), Positives = 138/327 (42%), Gaps = 71/327 (21%)

Query: 34  GNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK------------KKKIKRE 81
           G  ++Y+    LGRG  S V   I+    ++  VKI+                ++   +E
Sbjct: 14  GFYENYEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQELREATLKE 73

Query: 82  IKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTD-FKQLYQ--TLTDYDIRFYMY 138
           + IL  + G PNII L D  +   +    LVF+ +   + F  L +  TL++ + R  M 
Sbjct: 74  VDILRKVSGHPNIIQLKDTYE--TNTFFFLVFDLMKKGELFDYLTEKVTLSEKETRKIMR 131

Query: 139 EILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFK 198
            +L+ +   H + I+HRD+KP N+++D +   ++L D+G +    PG++      +  + 
Sbjct: 132 ALLEVICALHKLNIVHRDLKPENILLD-DDMNIKLTDFGFSCQLDPGEKLREVCGTPSYL 190

Query: 199 GPELLV-----DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTED 253
            PE++      ++  Y   +DMWS G ++ +++    PF+H      Q++ +        
Sbjct: 191 APEIIECSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPFWH----RKQMLML-------- 238

Query: 254 LYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLD-------KLLR 306
                                        R + S N    SPE  D+ D       + L 
Sbjct: 239 -----------------------------RMIMSGNYQFGSPEWDDYSDTVKDLVSRFLV 269

Query: 307 YDHQSRLTAREAMEHPYFYTVVKDQAR 333
              Q R TA EA+ HP+F   V ++ R
Sbjct: 270 VQPQKRYTAEEALAHPFFQQYVVEEVR 296


>5IG1-A nrPDB
          Length = 344

 Score = 80.5 bits (197), Expect = 1e-15,   Method: Compositional matrix adjust.
 Identities = 58/199 (29%), Positives = 101/199 (50%), Gaps = 14/199 (7%)

Query: 45  LGRGKYSEVFEAINITNNEKVVVKI-----LKPVKKKKIKREIKILENLRGGPNIITLAD 99
           +G+G +S V   +N    E   VK+     L+  +  KIKREI I  +L+   +I+++  
Sbjct: 25  IGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRSSEINKIKREIGICSSLQH-EHIVSMRR 83

Query: 100 IVKDPVSRTPALVFEHVNNTDFKQLYQTLTDY---DIRFYMYEILKALDYCHSMGIMHRD 156
             +D       LVFE+V+  +      T   Y   D    M++IL AL +CHS  I+HRD
Sbjct: 84  AFRDESHFY--LVFEYVSGGELFDEIVTRKFYNEKDASACMHQILSALQHCHSKNIIHRD 141

Query: 157 VKPHNVMIDHE--HRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLD 214
           +KP N+++  +  +  +++ D+GLA     G  Y     +  +  PE++     YD ++D
Sbjct: 142 LKPENLLLASKDPNAPVKITDFGLAVIMEQGPTYFGFAGTPGYLSPEVIRRVP-YDTAVD 200

Query: 215 MWSLGCMLASMIFRKEPFF 233
           +W+ G +L  ++    PF+
Sbjct: 201 VWACGVILYILLVGYPPFW 219


>4I6B-A nrPDB
          Length = 308

 Score = 80.5 bits (197), Expect = 1e-15,   Method: Compositional matrix adjust.
 Identities = 54/213 (25%), Positives = 109/213 (51%), Gaps = 15/213 (7%)

Query: 30  VVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL------KPVKKKKIKREIK 83
           +V+      Y   + LG+G +++ +E  ++TNN+    KI+      KP +++KI +EI+
Sbjct: 21  IVDPTTGKRYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKIDKEIE 80

Query: 84  ILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEI 140
            L  +    +++      +D       ++ E+ +      + +    LT+ ++R+Y+ +I
Sbjct: 81  -LHRILHHKHVVQFYHYFED--KENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQI 137

Query: 141 LKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASR-YFKG 199
           +  L Y H   I+HRD+K  N  I+ E  +L++ D+GLA    P +     +     +  
Sbjct: 138 VSGLKYLHEQEILHRDLKLGNFFIN-ESMELKVGDFGLAARLEPLEHRRRTICGTPNYLS 196

Query: 200 PELLVDYQMYDYSLDMWSLGCMLASMIFRKEPF 232
           PE+L + Q +    D+W+LGC++ +M+  + PF
Sbjct: 197 PEVL-NKQGHGAESDIWALGCVMYTMLLGRPPF 228


>5TUR-A nrPDB
          Length = 404

 Score = 80.5 bits (197), Expect = 1e-15,   Method: Compositional matrix adjust.
 Identities = 55/213 (25%), Positives = 101/213 (47%), Gaps = 17/213 (7%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK---------KKKIKREIKILE 86
           +  YQ+   LG G +  V+  I +++N  V +K ++  +           ++  E+ +L+
Sbjct: 126 ESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLK 185

Query: 87  NLRGG-PNIITLADIVKDPVSRTPALVFEHVNNT----DFKQLYQTLTDYDIRFYMYEIL 141
            +  G   +I L D  + P S    L+ E         DF      L +   R + +++L
Sbjct: 186 KVSSGFSGVIRLLDWFERPDSFV--LILERPEPVQDLFDFITERGALQEELARSFFWQVL 243

Query: 142 KALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPE 201
           +A+ +CH+ G++HRD+K  N++ID    +L+LID+G          Y     +R +  PE
Sbjct: 244 EAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK-DTVYTDFDGTRVYSPPE 302

Query: 202 LLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFH 234
            +  ++ +  S  +WSLG +L  M+    PF H
Sbjct: 303 WIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEH 335


>4REW-A nrPDB
          Length = 540

 Score = 80.5 bits (197), Expect = 1e-15,   Method: Compositional matrix adjust.
 Identities = 61/207 (29%), Positives = 98/207 (47%), Gaps = 13/207 (6%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK------KIKREIKILENLRGGP 92
           Y L   LG G + +V    +     KV VKIL   K +      KI+REI+ L+  R  P
Sbjct: 8   YILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRH-P 66

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNT---DFKQLYQTLTDYDIRFYMYEILKALDYCHS 149
           +II L  ++  P      +V E+V+     D+      L + + R    +IL  +DYCH 
Sbjct: 67  HIIKLYQVISTP--SDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHR 124

Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMY 209
             ++HRD+KP NV++D  H   ++ D+GL+     G+       S  +  PE++      
Sbjct: 125 HMVVHRDLKPENVLLD-AHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYA 183

Query: 210 DYSLDMWSLGCMLASMIFRKEPFFHGH 236
              +D+WS G +L +++    PF   H
Sbjct: 184 GPEVDIWSSGVILYALLCGTLPFDDDH 210


>3A8W-A nrPDB
          Length = 345

 Score = 80.5 bits (197), Expect = 1e-15,   Method: Compositional matrix adjust.
 Identities = 63/219 (28%), Positives = 106/219 (48%), Gaps = 22/219 (10%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKI---------KREIKILENL 88
           D+ L+R +GRG Y++V   + +   +++    +K VKK+ +         + E  + E  
Sbjct: 10  DFDLLRVIGRGSYAKVL-LVRLKKTDRIYA--MKVVKKELVNDDEDIDWVQTEKHVFEQA 66

Query: 89  RGGPNIITLADIVKDPVSRTPALVFEHVNNTDFK---QLYQTLTDYDIRFYMYEILKALD 145
              P ++ L    +         V E+VN  D     Q  + L +   RFY  EI  AL+
Sbjct: 67  SNHPFLVGLHSCFQ--TESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALN 124

Query: 146 YCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLV 204
           Y H  GI++RD+K  NV++D E   ++L D+G+  E   PG   +    +  +  PE+L 
Sbjct: 125 YLHERGIIYRDLKLDNVLLDSEGH-IKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILR 183

Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPF--FHGHDNYDQ 241
             + Y +S+D W+LG ++  M+  + PF      DN DQ
Sbjct: 184 G-EDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQ 221


>5UUU-A nrPDB
          Length = 547

 Score = 80.1 bits (196), Expect = 2e-15,   Method: Compositional matrix adjust.
 Identities = 68/275 (24%), Positives = 126/275 (45%), Gaps = 26/275 (9%)

Query: 25  DYESHVVEWGN--------QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK 76
           D  +   +W N         +D+ + R +GRG + EV+        +   +K L   K+ 
Sbjct: 178 DKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDK-KRI 236

Query: 77  KIKREIKILENLRGGPNIITLAD----IVKDPVSRTP---ALVFEHVNNTDFK---QLYQ 126
           K+K+   +  N R   ++++  D    +       TP   + + + +N  D       + 
Sbjct: 237 KMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHG 296

Query: 127 TLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ 186
             ++ D+RFY  EI+  L++ H+  +++RD+KP N+++D EH  +R+ D GLA  +   +
Sbjct: 297 VFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLD-EHGHVRISDLGLACDFSKKK 355

Query: 187 EYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFF-HGHDNYDQLVRI 245
            +   V +  +  PE+L     YD S D +SLGCML  ++    PF  H   +  ++ R+
Sbjct: 356 PH-ASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRM 414

Query: 246 AKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKR 280
              +  E      D ++ EL      +L R   +R
Sbjct: 415 TLTMAVE----LPDSFSPELRSLLEGLLQRDVNRR 445


>2WQN-A nrPDB
          Length = 310

 Score = 79.7 bits (195), Expect = 2e-15,   Method: Compositional matrix adjust.
 Identities = 60/222 (27%), Positives = 109/222 (49%), Gaps = 21/222 (9%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVK------ILKPVKKKKIKREIKILENLRGG 91
           ++++ +K+GRG++SEV+ A  + +   V +K      ++    +    +EI +L+ L   
Sbjct: 33  NFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQL-NH 91

Query: 92  PNIITL-ADIVKDPVSRTPALVFEHVNNTD-------FKQLYQTLTDYDIRFYMYEILKA 143
           PN+I   A  ++D       +V E  +  D       FK+  + + +  +  Y  ++  A
Sbjct: 92  PNVIKYYASFIED---NELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSA 148

Query: 144 LDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHP-GQEYNVRVASRYFKGPEL 202
           L++ HS  +MHRD+KP NV I      ++L D GL  F+       +  V + Y+  PE 
Sbjct: 149 LEHMHSRRVMHRDIKPANVFITATG-VVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPER 207

Query: 203 LVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVR 244
           + +   Y++  D+WSLGC+L  M   + PF+    N   L +
Sbjct: 208 IHE-NGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCK 248


>1NY3-A nrPDB
          Length = 400

 Score = 79.3 bits (194), Expect = 3e-15,   Method: Compositional matrix adjust.
 Identities = 59/210 (28%), Positives = 104/210 (49%), Gaps = 13/210 (6%)

Query: 37  DDYQLVRK-LGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNII 95
           DDY++  + LG G   +V +  N    EK  +K+L+   K +  RE+++       P+I+
Sbjct: 61  DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKAR--REVELHWRASQCPHIV 118

Query: 96  TLADIVKDPVSRTPAL--VFEHVNNTD-FKQLY----QTLTDYDIRFYMYEILKALDYCH 148
            + D+ ++  +    L  V E ++  + F ++     Q  T+ +    M  I +A+ Y H
Sbjct: 119 RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 178

Query: 149 SMGIMHRDVKPHNVMIDHE--HRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDY 206
           S+ I HRDVKP N++   +  +  L+L D+G A+             + Y+  PE+L   
Sbjct: 179 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVL-GP 237

Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGH 236
           + YD S DMWSLG ++  ++    PF+  H
Sbjct: 238 EKYDKSCDMWSLGVIMYILLCGYPPFYSNH 267


>4CQG-A nrPDB
          Length = 331

 Score = 79.3 bits (194), Expect = 3e-15,   Method: Compositional matrix adjust.
 Identities = 70/294 (23%), Positives = 131/294 (44%), Gaps = 51/294 (17%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP----VKKKKIKREIKILENLRGGPNI 94
           Y+L   +G G +++V  A ++   E V +KI+          ++K EI  L++LR   +I
Sbjct: 11  YELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGSDLPRVKTEIDALKSLRH-QHI 69

Query: 95  ITLADIVKDPVSRTPALVFEHVNNT---DFKQLYQTLTDYDIRFYMYEILKALDYCHSMG 151
             L  +++        +V E+       D+      L++ + R    +IL A+ Y HS G
Sbjct: 70  CQLYHVLE--TKNKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQILSAVAYVHSQG 127

Query: 152 IMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVR--VASRYFKGPELLVDYQMY 209
             HRD+KP N++ D  H KL+LID+GL       ++Y+++    S  +  PEL+      
Sbjct: 128 YAHRDLKPENLLFDENH-KLKLIDFGLCAKPKGNKDYHLQECCGSLAYAAPELIQGKSYL 186

Query: 210 DYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRF 269
               D+WS+G +L  ++    PF    D+ + +    K++                    
Sbjct: 187 GSEADVWSMGILLYVLMCGFLPF----DDDNVMALYKKIMR------------------- 223

Query: 270 NDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323
               G++   +W           +SP ++  L ++L+ D + R++ R  + HP+
Sbjct: 224 ----GKYEVPKW-----------LSPSSILLLQQMLQVDPKKRISMRNLLNHPW 262


>2OZA-A nrPDB
          Length = 356

 Score = 79.3 bits (194), Expect = 3e-15,   Method: Compositional matrix adjust.
 Identities = 59/210 (28%), Positives = 104/210 (49%), Gaps = 13/210 (6%)

Query: 37  DDYQLVRK-LGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNII 95
           DDY++  + LG G   +V +  N    EK  +K+L+   K +  RE+++       P+I+
Sbjct: 17  DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKAR--REVELHWRASQCPHIV 74

Query: 96  TLADIVKDPVSRTPAL--VFEHVNNTD-FKQLY----QTLTDYDIRFYMYEILKALDYCH 148
            + D+ ++  +    L  V E ++  + F ++     Q  T+ +    M  I +A+ Y H
Sbjct: 75  RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 134

Query: 149 SMGIMHRDVKPHNVMIDHE--HRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDY 206
           S+ I HRDVKP N++   +  +  L+L D+G A+             + Y+  PE+L   
Sbjct: 135 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVL-GP 193

Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGH 236
           + YD S DMWSLG ++  ++    PF+  H
Sbjct: 194 EKYDKSCDMWSLGVIMYILLCGYPPFYSNH 223


>4B6L-A nrPDB
          Length = 281

 Score = 79.3 bits (194), Expect = 3e-15,   Method: Compositional matrix adjust.
 Identities = 54/200 (27%), Positives = 105/200 (52%), Gaps = 15/200 (7%)

Query: 43  RKLGRGKYSEVFEAINITNNEKVVVKIL------KPVKKKKIKREIKILENLRGGPNIIT 96
           R LG+G ++  +EA +        VK++      KP +++KI  EI++  +L+   +I+ 
Sbjct: 15  RLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHR-HIVR 73

Query: 97  LADIVKDPVSRTPALVFEHVNNTDFKQLYQ---TLTDYDIRFYMYEILKALDYCHSMGIM 153
            +   +D  +    +  E  +      +++   TL + ++R+Y+ +IL  L Y H  GI+
Sbjct: 74  FSHHFED--ADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGIL 131

Query: 154 HRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVA-SRYFKGPELLVDYQMYDYS 212
           HRD+K  N  I  E+ +L++ D+GLA    P ++    +  +  +  PE+L+  Q +   
Sbjct: 132 HRDLKLGNFFIT-ENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLR-QGHGPE 189

Query: 213 LDMWSLGCMLASMIFRKEPF 232
            D+WSLGC++ +++    PF
Sbjct: 190 ADVWSLGCVMYTLLCGSPPF 209


>3BGP-A nrPDB
          Length = 333

 Score = 79.3 bits (194), Expect = 3e-15,   Method: Compositional matrix adjust.
 Identities = 55/213 (25%), Positives = 101/213 (47%), Gaps = 17/213 (7%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK---------KKKIKREIKILE 86
           +  YQ+   LG G +  V+  I +++N  V +K ++  +           ++  E+ +L+
Sbjct: 55  ESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLK 114

Query: 87  NLRGG-PNIITLADIVKDPVSRTPALVFEHVNNT----DFKQLYQTLTDYDIRFYMYEIL 141
            +  G   +I L D  + P S    L+ E         DF      L +   R + +++L
Sbjct: 115 KVSSGFSGVIRLLDWFERPDSFV--LILERPEPVQDLFDFITERGALQEELARSFFWQVL 172

Query: 142 KALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPE 201
           +A+ +CH+ G++HRD+K  N++ID    +L+LID+G          Y     +R +  PE
Sbjct: 173 EAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK-DTVYTDFDGTRVYSPPE 231

Query: 202 LLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFH 234
            +  ++ +  S  +WSLG +L  M+    PF H
Sbjct: 232 WIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEH 264


>3PVW-A nrPDB
          Length = 695

 Score = 79.3 bits (194), Expect = 3e-15,   Method: Compositional matrix adjust.
 Identities = 68/275 (24%), Positives = 126/275 (45%), Gaps = 26/275 (9%)

Query: 25  DYESHVVEWGN--------QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK 76
           D  +   +W N         +D+ + R +GRG + EV+        +   +K L   K+ 
Sbjct: 169 DKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDK-KRI 227

Query: 77  KIKREIKILENLRGGPNIITLAD----IVKDPVSRTP---ALVFEHVNNTDFK---QLYQ 126
           K+K+   +  N R   ++++  D    +       TP   + + + +N  D       + 
Sbjct: 228 KMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHG 287

Query: 127 TLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ 186
             ++ D+RFY  EI+  L++ H+  +++RD+KP N+++D EH  +R+ D GLA  +   +
Sbjct: 288 VFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLD-EHGHVRISDLGLACDFSKKK 346

Query: 187 EYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFF-HGHDNYDQLVRI 245
            +   V +  +  PE+L     YD S D +SLGCML  ++    PF  H   +  ++ R+
Sbjct: 347 PH-ASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRM 405

Query: 246 AKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKR 280
              +  E      D ++ EL      +L R   +R
Sbjct: 406 TLTMAVE----LPDSFSPELRSLLEGLLQRDVNRR 436


>4RC3-A nrPDB
          Length = 289

 Score = 79.0 bits (193), Expect = 4e-15,   Method: Compositional matrix adjust.
 Identities = 55/213 (25%), Positives = 101/213 (47%), Gaps = 17/213 (7%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK---------KKKIKREIKILE 86
           +  YQ+   LG G +  V+  I +++N  V +K ++  +           ++  E+ +L+
Sbjct: 11  ESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLK 70

Query: 87  NLRGG-PNIITLADIVKDPVSRTPALVFEHVNNT----DFKQLYQTLTDYDIRFYMYEIL 141
            +  G   +I L D  + P S    L+ E         DF      L +   R + +++L
Sbjct: 71  KVSSGFSGVIRLLDWFERPDSFV--LILERPEPVQDLFDFITERGALQEELARSFFWQVL 128

Query: 142 KALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPE 201
           +A+ +CH+ G++HRD+K  N++ID    +L+LID+G          Y     +R +  PE
Sbjct: 129 EAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK-DTVYTDFDGTRVYSPPE 187

Query: 202 LLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFH 234
            +  ++ +  S  +WSLG +L  M+    PF H
Sbjct: 188 WIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEH 220


>2V7O-A nrPDB
          Length = 336

 Score = 79.0 bits (193), Expect = 4e-15,   Method: Compositional matrix adjust.
 Identities = 75/300 (25%), Positives = 141/300 (47%), Gaps = 53/300 (17%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK-----KKKIKREIKILENLRGG 91
           DDYQL  +LG+G +S V   +  T  ++   KI+   K      +K++RE +I   L+  
Sbjct: 31  DDYQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSARDHQKLEREARICRLLKH- 89

Query: 92  PNIITLADIVKDPVSRTPALVFEHVNNTD-FKQLY--QTLTDYDIRFYMYEILKALDYCH 148
           PNI+ L D + +       LVF+ V   + F+ +   +  ++ D    +++IL+++++ H
Sbjct: 90  PNIVRLHDSISEEGFHY--LVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIH 147

Query: 149 SMGIMHRDVKPHNVMIDHEHR--KLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLVD 205
              I+HRD+KP N+++  + +   ++L D+GLA E     Q +     +  +  PE+L  
Sbjct: 148 QHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRK 207

Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFF--HGHDNYDQLVRIAKVLGTEDLYDYIDKYNI 263
              Y   +D+W+ G +L  ++    PF+    H  Y Q+   A        YD+      
Sbjct: 208 -DPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGA--------YDF------ 252

Query: 264 ELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323
                            W+          V+PEA + ++++L  +   R+TA +A++HP+
Sbjct: 253 -------------PSPEWDT---------VTPEAKNLINQMLTINPAKRITADQALKHPW 290


>4CFH-A nrPDB
          Length = 493

 Score = 78.6 bits (192), Expect = 4e-15,   Method: Compositional matrix adjust.
 Identities = 61/207 (29%), Positives = 98/207 (47%), Gaps = 13/207 (6%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK------KIKREIKILENLRGGP 92
           Y L   LG G + +V    +     KV VKIL   K +      KI+REI+ L+  R  P
Sbjct: 35  YILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRH-P 93

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNT---DFKQLYQTLTDYDIRFYMYEILKALDYCHS 149
           +II L  ++  P      +V E+V+     D+      L + + R    +IL  +DYCH 
Sbjct: 94  HIIKLYQVISTP--SDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHR 151

Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMY 209
             ++HRD+KP NV++D  H   ++ D+GL+     G+       S  +  PE++      
Sbjct: 152 HMVVHRDLKPENVLLD-AHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYA 210

Query: 210 DYSLDMWSLGCMLASMIFRKEPFFHGH 236
              +D+WS G +L +++    PF   H
Sbjct: 211 GPEVDIWSSGVILYALLCGTLPFDDDH 237


>3KA0-A nrPDB
          Length = 320

 Score = 78.6 bits (192), Expect = 4e-15,   Method: Compositional matrix adjust.
 Identities = 59/210 (28%), Positives = 104/210 (49%), Gaps = 13/210 (6%)

Query: 37  DDYQLVRK-LGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNII 95
           DDY++  + LG G   +V +  N    EK  +K+L+   K +  RE+++       P+I+
Sbjct: 15  DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKAR--REVELHWRASQCPHIV 72

Query: 96  TLADIVKDPVSRTPAL--VFEHVNNTD-FKQLY----QTLTDYDIRFYMYEILKALDYCH 148
            + D+ ++  +    L  V E ++  + F ++     Q  T+ +    M  I +A+ Y H
Sbjct: 73  RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 132

Query: 149 SMGIMHRDVKPHNVMIDHE--HRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDY 206
           S+ I HRDVKP N++   +  +  L+L D+G A+             + Y+  PE+L   
Sbjct: 133 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTEPCYTPYYVAPEVL-GP 191

Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGH 236
           + YD S DMWSLG ++  ++    PF+  H
Sbjct: 192 EKYDKSCDMWSLGVIMYILLCGYPPFYSNH 221


>5YV8-A nrPDB
          Length = 298

 Score = 78.6 bits (192), Expect = 4e-15,   Method: Compositional matrix adjust.
 Identities = 62/233 (26%), Positives = 109/233 (46%), Gaps = 40/233 (17%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKR---------------- 80
           + Y L  ++G+G Y  V  A N  +N    +K+L   KKK I++                
Sbjct: 13  NQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLS--KKKLIRQAGFPRRPPPRGTRPAP 70

Query: 81  ---------------EIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQL- 124
                          EI IL+ L   PN++ L +++ DP      +VFE VN     ++ 
Sbjct: 71  GGCIQPRGPIEQVYQEIAILKKLDH-PNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVP 129

Query: 125 -YQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFY 182
             + L++   RFY  +++K ++Y H   I+HRD+KP N+++  E   +++ D+G++ EF 
Sbjct: 130 TLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVG-EDGHIKIADFGVSNEFK 188

Query: 183 HPGQEYNVRVASRYFKGPELLVDYQ--MYDYSLDMWSLGCMLASMIFRKEPFF 233
                 +  V +  F  PE L + +      +LD+W++G  L   +F + PF 
Sbjct: 189 GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFM 241


>5D9K-A nrPDB
          Length = 330

 Score = 78.6 bits (192), Expect = 4e-15,   Method: Compositional matrix adjust.
 Identities = 60/229 (26%), Positives = 115/229 (50%), Gaps = 18/229 (7%)

Query: 32  EWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLR-- 89
           E  +   ++L++ LG+G + +VF    I+ ++   +  +K +KK  +K   ++   +   
Sbjct: 25  EKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERD 84

Query: 90  -----GGPNIITLADIVKDPVSRTPALVFEHVNNTD-FKQLYQTL--TDYDIRFYMYEIL 141
                  P I+ L    +        L+ + +   D F +L + +  T+ D++FY+ E+ 
Sbjct: 85  ILVEVNHPFIVKLHYAFQ--TEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELA 142

Query: 142 KALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE--FYHPGQEYNVRVASRYFKG 199
            ALD+ HS+GI++RD+KP N+++D E   ++L D+GL++    H  + Y+      Y   
Sbjct: 143 LALDHLHSLGIIYRDLKPENILLDEEGH-IKLTDFGLSKESIDHEKKAYSFCGTVEYM-A 200

Query: 200 PELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKV 248
           PE +V+ + +  S D WS G ++  M+    P F G D  + +  I K 
Sbjct: 201 PE-VVNRRGHTQSADWWSFGVLMFEMLTGTLP-FQGKDRKETMTMILKA 247


>2YCR-A nrPDB
          Length = 323

 Score = 78.6 bits (192), Expect = 5e-15,   Method: Compositional matrix adjust.
 Identities = 75/307 (24%), Positives = 129/307 (42%), Gaps = 55/307 (17%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK-----------KKKIKREIKI 84
           +D+Y + + LG G   EV  A      +KV +KI+   K              ++ EI+I
Sbjct: 9   RDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEI 68

Query: 85  LENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTD-FKQLY--QTLTDYDIRFYMYEIL 141
           L+ L   P II + +      +    +V E +   + F ++   + L +   + Y Y++L
Sbjct: 69  LKKL-NHPCIIKIKNFFD---AEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQML 124

Query: 142 KALDYCHSMGIMHRDVKPHNVMIDHEHRK--LRLIDWGLAEFYHPGQEYNVRVASRYFKG 199
            A+ Y H  GI+HRD+KP NV++  +     +++ D+G ++             +  +  
Sbjct: 125 LAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLA 184

Query: 200 PELLVDYQM--YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDY 257
           PE+LV      Y+ ++D WSLG +L   +    PF           +I     T   Y++
Sbjct: 185 PEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQI-----TSGKYNF 239

Query: 258 IDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTARE 317
           I +   E                            VS +ALD + KLL  D ++R T  E
Sbjct: 240 IPEVWAE----------------------------VSEKALDLVKKLLVVDPKARFTTEE 271

Query: 318 AMEHPYF 324
           A+ HP+ 
Sbjct: 272 ALRHPWL 278


>4JXF-A nrPDB
          Length = 266

 Score = 78.6 bits (192), Expect = 5e-15,   Method: Compositional matrix adjust.
 Identities = 69/299 (23%), Positives = 136/299 (45%), Gaps = 54/299 (18%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL------KPVKKKKIKREIKILENLRG 90
           +D+++   LG+G ++ V+ A +I    +V +K++      K    ++++ E+KI   L+ 
Sbjct: 7   EDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKH 66

Query: 91  GPNIITLADIVKDPVSRTPALVFEHVNNTD----FKQLYQTLTDYDIRFYMYEILKALDY 146
            P+I+ L +  +D  S    LV E  +N +     K   +  ++ + R +M++I+  + Y
Sbjct: 67  -PSILELYNYFED--SNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLY 123

Query: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLVD 205
            HS GI+HRD+   N+++   +  +++ D+GLA +   P +++     +  +  PE +  
Sbjct: 124 LHSHGILHRDLTLSNLLLT-RNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPE-IAT 181

Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIEL 265
              +    D+WSLGCM  +++  + PF     + D    +   L    L DY        
Sbjct: 182 RSAHGLESDVWSLGCMFYTLLIGRPPF-----DTDT---VKNTLNKVVLADY-------- 225

Query: 266 DPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324
                                 E    +S EA D + +LLR +   RL+    ++HP+ 
Sbjct: 226 ----------------------EMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFM 262


>4D28-A nrPDB
          Length = 446

 Score = 78.2 bits (191), Expect = 5e-15,   Method: Compositional matrix adjust.
 Identities = 64/206 (31%), Positives = 110/206 (53%), Gaps = 18/206 (8%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKI------LKPVKKKKIKREIKILENLRGGP 92
           Y++ R +G G +++V  A N    + V +KI      LK     +IKREI I++ +R  P
Sbjct: 11  YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH-P 69

Query: 93  NIITLADIVKDPVSRTPA-LVFEHVNNTD-FKQLYQT--LTDYDIRFYMYEILKALDYCH 148
           NI+ L +++    S++   +V E V   + F ++     L + + R Y  +++ A+ +CH
Sbjct: 70  NIVRLYEVL---ASKSKIYIVLEFVTGGELFDRIVHKGRLKEDESRKYFQQLVDAVAHCH 126

Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE-YNVRVASRYFKGPELLVDYQ 207
           S G+ HRD+KP N+++D  +  L++ D+GL+     G E  N    +  +  PE+L   Q
Sbjct: 127 SKGVYHRDLKPENLLLD-TNGNLKVSDFGLSALPQEGVELLNDTCGTPNYVAPEVL-SGQ 184

Query: 208 MYDYS-LDMWSLGCMLASMIFRKEPF 232
            YD S  D+WS G +L  ++    PF
Sbjct: 185 GYDGSAADIWSCGVILFVILAGYLPF 210


>2Z7Q-A nrPDB
          Length = 321

 Score = 78.2 bits (191), Expect = 5e-15,   Method: Compositional matrix adjust.
 Identities = 64/239 (26%), Positives = 121/239 (50%), Gaps = 26/239 (10%)

Query: 28  SHVVEWGNQ----DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIK 83
           +H V+ G++      ++L++ LG+G + +VF    +T  +   +  +K +KK  +K    
Sbjct: 15  THHVKAGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLK---- 70

Query: 84  ILENLRGGPNIITLADIVKDPVSR---------TPALVFEHVNNTD-FKQLYQTL--TDY 131
           + + +R       LAD+    V +            L+ + +   D F +L + +  T+ 
Sbjct: 71  VRDRVRTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEE 130

Query: 132 DIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE--FYHPGQEYN 189
           D++FY+ E+   LD+ HS+GI++RD+KP N+++D E   ++L D+GL++    H  + Y+
Sbjct: 131 DVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGH-IKLTDFGLSKEAIDHEKKAYS 189

Query: 190 VRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKV 248
                 Y   PE +V+ Q + +S D WS G ++  M+    P F G D  + +  I K 
Sbjct: 190 FCGTVEYM-APE-VVNRQGHSHSADWWSYGVLMFEMLTGSLP-FQGKDRKETMTLILKA 245


>5JZN-A nrPDB
          Length = 280

 Score = 78.2 bits (191), Expect = 6e-15,   Method: Compositional matrix adjust.
 Identities = 75/296 (25%), Positives = 132/296 (44%), Gaps = 50/296 (16%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK----IKREIKILENLRGGPNI 94
           Y++ R +G G ++ V E +  +   +  +KI+K  K +     I+ E+ IL  ++  PNI
Sbjct: 21  YKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHMIQNEVSILRRVKH-PNI 79

Query: 95  ITLADIVKDPVSRTPALVFEHVNNTD-FKQLYQT--LTDYDIRFYMYEILKALDYCHSMG 151
           + L + +  P      LV E V   D F  +  T   T+ D    +Y +  A+ Y HS+ 
Sbjct: 80  VLLIEEMDVPTELY--LVMELVKGGDLFDAITSTNKYTERDASGMLYNLASAIKYLHSLN 137

Query: 152 IMHRDVKPHNVMIDHEH----RKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQ 207
           I+HRD+KP N+++ +EH    + L+L D+GLA     G  Y V   +  +  PE++ +  
Sbjct: 138 IVHRDIKPENLLV-YEHQDGSKSLKLGDFGLATIVD-GPLYTV-CGTPTYVAPEIIAETG 194

Query: 208 MYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDP 267
            Y   +D+W+ G +   ++    PF    D+             E L+D I    ++   
Sbjct: 195 -YGLKVDIWAAGVITYILLCGFPPFRGSGDD------------QEVLFDQILMGQVDFPS 241

Query: 268 RFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323
            +           W+          VS  A + +  +L  D   R +A + +EHP+
Sbjct: 242 PY-----------WDN---------VSDSAKELITMMLLVDVDQRFSAVQVLEHPW 277


>6FD3-A nrPDB
          Length = 300

 Score = 77.8 bits (190), Expect = 7e-15,   Method: Compositional matrix adjust.
 Identities = 70/294 (23%), Positives = 131/294 (44%), Gaps = 50/294 (17%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVK---ILKPVKKKKIKREIKILENLRGGPNII 95
           Y    K+G+G    V+ A++I   ++V +K   + +  KK+ I  EI ++   +  PNI+
Sbjct: 24  YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKN-PNIV 82

Query: 96  TLAD--IVKDPVSRTPALVFEHVNNTDFKQLYQ--TLTDYDIRFYMYEILKALDYCHSMG 151
              D  +V D +     +V E++       +     + +  I     E L+ALD+ HS  
Sbjct: 83  NYLDSYLVGDEL----WVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQ 138

Query: 152 IMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ-EYNVRVASRYFKGPELLVDYQMYD 210
           ++HRD+K  N+++  +   ++L D+G      P Q + +  V + Y+  PE +V  + Y 
Sbjct: 139 VIHRDIKSDNILLGMDG-SVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPE-VVTRKAYG 196

Query: 211 YSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFN 270
             +D+WSLG M   M+  + P+   ++N  + + +    GT +L                
Sbjct: 197 PKVDIWSLGIMAIEMVEGEPPYL--NENPLRALYLIATNGTPEL---------------- 238

Query: 271 DILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324
                            +N   +S    DFL++ L  D   R +A+E ++HP+ 
Sbjct: 239 -----------------QNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFL 275


>6FYV-A nrPDB
          Length = 337

 Score = 77.0 bits (188), Expect = 1e-14,   Method: Compositional matrix adjust.
 Identities = 79/335 (23%), Positives = 152/335 (45%), Gaps = 67/335 (20%)

Query: 39  YQLVRKLGRGKYSEVFEAINI-TNNEKVVVKILKPVK--KKKIKREIKILENLRGG-PNI 94
           Y++V  LG G + +V E I+   +   V VKI+K V   ++  + EI++LE+L    PN 
Sbjct: 16  YEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPN- 74

Query: 95  ITLADIVKDPVSRTPALV--FEHVNNTDFKQLYQTLTDYD--------------IRFYMY 138
                     V R   ++  F+H  +         L+ YD              IR   Y
Sbjct: 75  ---------SVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAY 125

Query: 139 EILKALDYCHSMGIMHRDVKPHNVM-------------IDHEHRKL-----RLIDWGLAE 180
           +I +++++ H   + H D+KP N++             +  + R L     +++D+G A 
Sbjct: 126 QICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSAT 185

Query: 181 FYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYD 240
           +    + ++  V++R+++ PE+++    +    D+WS+GC+L    +     F  HD+ +
Sbjct: 186 Y--DDEHHSTLVSTRHYRAPEVILALG-WSQPCDVWSIGCILIEY-YLGFTVFQTHDSKE 241

Query: 241 QLVRIAKVLG--TEDLYDYIDK----YNIELDPRFNDILGRHSRKRWE-----RFVHSEN 289
            L  + ++LG   + +     K    ++ +LD   +   GR+ R+R +        H E 
Sbjct: 242 HLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEE 301

Query: 290 QHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324
                 +  D + ++L YD   R+T  EA++HP+F
Sbjct: 302 H----EKLFDLVRRMLEYDPTQRITLDEALQHPFF 332


>3UC3-A nrPDB
          Length = 361

 Score = 77.0 bits (188), Expect = 1e-14,   Method: Compositional matrix adjust.
 Identities = 71/300 (23%), Positives = 128/300 (42%), Gaps = 49/300 (16%)

Query: 35  NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK--PVKKKKIKREIKILENLRGGP 92
           + D Y  V+ +G G +       +    E V VK ++      + ++REI    +LR  P
Sbjct: 18  DSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGAAIDENVQREIINHRSLRH-P 76

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDY------DIRFYMYEILKALDY 146
           NI+   +++  P     A++ E+ +     +LY+ + +       + RF+  ++L  + Y
Sbjct: 77  NIVRFKEVILTPTHL--AIIMEYASG---GELYERICNAGRFSEDEARFFFQQLLSGVSY 131

Query: 147 CHSMGIMHRDVKPHNVMIDHEHR-KLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVD 205
           CHSM I HRD+K  N ++D     +L++ D+G ++      +    V +  +  PE+L+ 
Sbjct: 132 CHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL- 190

Query: 206 YQMYDYSL-DMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIE 264
            Q YD  + D+WS G  L  M+    PF    +  D    I ++L          KY+I 
Sbjct: 191 RQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSV--------KYSIP 242

Query: 265 LDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324
            D R                        +SPE    + ++   D  +R++  E   H +F
Sbjct: 243 DDIR------------------------ISPECCHLISRIFVADPATRISIPEIKTHSWF 278


>2BRG-A nrPDB
          Length = 297

 Score = 77.0 bits (188), Expect = 1e-14,   Method: Compositional matrix adjust.
 Identities = 59/218 (27%), Positives = 107/218 (49%), Gaps = 20/218 (9%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNI-- 94
           +D+ LV+ LG G Y EV  A+N    E V VKI+       +KR +   EN++    I  
Sbjct: 7   EDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVD------MKRAVDCPENIKKEICINK 60

Query: 95  -ITLADIVKDPVSRTPA----LVFEHVNNTDFKQLYQ---TLTDYDIRFYMYEILKALDY 146
            +   ++VK    R       L  E+ +  +     +    + + D + + ++++  + Y
Sbjct: 61  MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVY 120

Query: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE-FYHPGQE--YNVRVASRYFKGPELL 203
            H +GI HRD+KP N+++D E   L++ D+GLA  F +  +E   N    +  +  PELL
Sbjct: 121 LHGIGITHRDIKPENLLLD-ERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELL 179

Query: 204 VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQ 241
              + +   +D+WS G +L +M+  + P+    D+  +
Sbjct: 180 KRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQE 217


>4RED-A nrPDB
          Length = 351

 Score = 77.0 bits (188), Expect = 1e-14,   Method: Compositional matrix adjust.
 Identities = 60/207 (28%), Positives = 97/207 (46%), Gaps = 13/207 (6%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK------KIKREIKILENLRGGP 92
           Y L   LG G + +V    +      V VKIL   K +      KI+REI+ L+  R  P
Sbjct: 16  YILGDTLGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLDVVGKIRREIQNLKLFRH-P 74

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNT---DFKQLYQTLTDYDIRFYMYEILKALDYCHS 149
           +II L  ++  P      +V E+V+     D+      L + + R    +IL  +DYCH 
Sbjct: 75  HIIKLYQVISTP--SDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHR 132

Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMY 209
             ++HRD+KP NV++D  H   ++ D+GL+     G+       S  +  PE++      
Sbjct: 133 HMVVHRDLKPENVLLD-AHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYA 191

Query: 210 DYSLDMWSLGCMLASMIFRKEPFFHGH 236
              +D+WS G +L +++    PF   H
Sbjct: 192 GPEVDIWSSGVILYALLCGTLPFDDDH 218


>3I6U-A nrPDB
          Length = 419

 Score = 75.9 bits (185), Expect = 3e-14,   Method: Compositional matrix adjust.
 Identities = 74/307 (24%), Positives = 129/307 (42%), Gaps = 55/307 (17%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK-----------KKKIKREIKI 84
           +D+Y + + LG G   EV  A      +KV ++I+   K              ++ EI+I
Sbjct: 134 RDEYIMSKTLGSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSAREADPALNVETEIEI 193

Query: 85  LENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTD-FKQLY--QTLTDYDIRFYMYEIL 141
           L+ L   P II + +      +    +V E +   + F ++   + L +   + Y Y++L
Sbjct: 194 LKKL-NHPCIIKIKNFFD---AEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQML 249

Query: 142 KALDYCHSMGIMHRDVKPHNVMIDHEHRK--LRLIDWGLAEFYHPGQEYNVRVASRYFKG 199
            A+ Y H  GI+HRD+KP NV++  +     +++ D+G ++             +  +  
Sbjct: 250 LAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLA 309

Query: 200 PELLVDYQM--YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDY 257
           PE+LV      Y+ ++D WSLG +L   +    PF           +I     T   Y++
Sbjct: 310 PEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQI-----TSGKYNF 364

Query: 258 IDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTARE 317
           I +   E                            VS +ALD + KLL  D ++R T  E
Sbjct: 365 IPEVWAE----------------------------VSEKALDLVKKLLVVDPKARFTTEE 396

Query: 318 AMEHPYF 324
           A+ HP+ 
Sbjct: 397 ALRHPWL 403


>2JD5-A nrPDB
          Length = 373

 Score = 75.9 bits (185), Expect = 3e-14,   Method: Compositional matrix adjust.
 Identities = 99/355 (27%), Positives = 164/355 (46%), Gaps = 65/355 (18%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILK--PVKKKKIKREIKIL----------E 86
           Y LVRKLG G +S V+ A ++ NN  V +KI++   V  +  + EIK+L          E
Sbjct: 21  YILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVRGDKVYTEAAEDEIKLLQRVNDADNTKE 80

Query: 87  NLRGGPNIITLADIV--KDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIR----FYMYEI 140
           +  G  +I+ L D    K P      +VFE +     + L   +  Y+ R     Y+ +I
Sbjct: 81  DSMGANHILKLLDHFNHKGPNGVHVVMVFEVLG----ENLLALIKKYEHRGIPLIYVKQI 136

Query: 141 LK----ALDYCH-SMGIMHRDVKPHNVMID-----HEHRKLRLIDWGLAEFYHPGQEYNV 190
            K     LDY H   GI+H D+KP NV+++         ++++ D G A +Y   + Y  
Sbjct: 137 SKQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNACWY--DEHYTN 194

Query: 191 RVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMI---FRKEPFFHGHD---NYDQLVR 244
            + +R ++ PE+L+    +    D+WS  C++  +I   F  EP   GH    + D + +
Sbjct: 195 SIQTREYRSPEVLLGAP-WGCGADIWSTACLIFELITGDFLFEP-DEGHSYTKDDDHIAQ 252

Query: 245 IAKVLGTEDLYDYIDKYNIELDPRFND--ILGRHSR-KRW-------ERFVHSENQHLVS 294
           I ++LG  +L  Y+ +        FN   +L   S+ K W       E++  S+++   +
Sbjct: 253 IIELLG--ELPSYLLRNGKYTRTFFNSRGLLRNISKLKFWPLEDVLTEKYKFSKDE---A 307

Query: 295 PEALDFLDKLLRYDHQSRLTAREAMEHPYFYTV-------VKDQARMGSSS-MPG 341
            E  DFL  +L+ D + R  A   + HP+           V D+   GS S +PG
Sbjct: 308 KEISDFLSPMLQLDPRKRADAGGLVNHPWLKDTLGMEEIRVPDRELYGSGSDIPG 362


>1U5R-A nrPDB
          Length = 348

 Score = 75.9 bits (185), Expect = 3e-14,   Method: Compositional matrix adjust.
 Identities = 58/204 (28%), Positives = 102/204 (50%), Gaps = 18/204 (8%)

Query: 42  VRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK------IKREIKILENLRGGPNII 95
           +R++G G +  V+ A ++ N+E V +K +    K+       I +E++ L+ LR  PN I
Sbjct: 59  LREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRH-PNTI 117

Query: 96  TLADIVKDPVSRTPALVFEHV--NNTDFKQLYQT-LTDYDIRFYMYEILKALDYCHSMGI 152
                       T  LV E+   + +D  ++++  L + +I    +  L+ L Y HS  +
Sbjct: 118 QYRGCYLR--EHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHSHNM 175

Query: 153 MHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLV--DYQMYD 210
           +HRDVK  N+++  E   ++L D+G A    P   +   V + Y+  PE+++  D   YD
Sbjct: 176 IHRDVKAGNILLS-EPGLVKLGDFGSASIMAPANSF---VGTPYWMAPEVILAMDEGQYD 231

Query: 211 YSLDMWSLGCMLASMIFRKEPFFH 234
             +D+WSLG     +  RK P F+
Sbjct: 232 GKVDVWSLGITCIELAERKPPLFN 255


>5J5T-A nrPDB
          Length = 370

 Score = 75.5 bits (184), Expect = 3e-14,   Method: Compositional matrix adjust.
 Identities = 68/294 (23%), Positives = 139/294 (47%), Gaps = 24/294 (8%)

Query: 34  GNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK---IKREIKILENLRG 90
           G+Q+D++L++++G G Y +V++A N+   E   +K++K    +    +++EI ++++ + 
Sbjct: 1   GSQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCK- 59

Query: 91  GPNIITL--ADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALD 145
            PNI+    + + +D +     +  E       + +Y     L++  I +   E L+ L 
Sbjct: 60  HPNIVAYFGSYLRRDKL----WICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLY 115

Query: 146 YCHSMGIMHRDVKPHNVMI-DHEHRKLRLIDWGL-AEFYHPGQEYNVRVASRYFKGPELL 203
           Y HS G MHRD+K  N+++ D+ H  ++L D+G+ A+      +    + + Y+  PE+ 
Sbjct: 116 YLHSKGKMHRDIKGANILLTDNGH--VKLADFGVSAQITATIAKRKAFIGTPYWMAPEVA 173

Query: 204 VDYQM--YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKY 261
              +   Y+   D+W++G     +   + P F  H      +          L D + K+
Sbjct: 174 AVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKM-KW 232

Query: 262 NIELDPRFNDILGRHSRKR--WERFVHSE--NQHLVSPEALDFLDKLLRYDHQS 311
           +          L ++ +KR   E+ +      QHL    A++ LDK+   DH +
Sbjct: 233 SNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQHLTRSLAIELLDKVNNPDHST 286


>4X7Q-B nrPDB
          Length = 312

 Score = 75.5 bits (184), Expect = 4e-14,   Method: Compositional matrix adjust.
 Identities = 54/213 (25%), Positives = 96/213 (45%), Gaps = 19/213 (8%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL--------KPVKKK-KIKREIKILE 86
           + +Y+L   LG+G +  VF    +T+  +V +K++         P+        E+ +L 
Sbjct: 30  EAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLW 89

Query: 87  NLRGG---PNIITLADIVKDPVSRTPALVFEHV----NNTDFKQLYQTLTDYDIRFYMYE 139
            +  G   P +I L D  +        LV E      +  D+      L +   R +  +
Sbjct: 90  KVGAGGGHPGVIRLLDWFE--TQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQ 147

Query: 140 ILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKG 199
           ++ A+ +CHS G++HRD+K  N++ID      +LID+G     H  + Y     +R +  
Sbjct: 148 VVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLH-DEPYTDFDGTRVYSP 206

Query: 200 PELLVDYQMYDYSLDMWSLGCMLASMIFRKEPF 232
           PE +  +Q +     +WSLG +L  M+    PF
Sbjct: 207 PEWISRHQYHALPATVWSLGILLYDMVCGDIPF 239


>3FXW-A nrPDB
          Length = 336

 Score = 75.1 bits (183), Expect = 4e-14,   Method: Compositional matrix adjust.
 Identities = 58/207 (28%), Positives = 101/207 (48%), Gaps = 14/207 (6%)

Query: 37  DDYQLVRK-LGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNII 95
           DDYQL ++ LG G   +V E  +    +K  +K+L      K ++E+       GGP+I+
Sbjct: 28  DDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLL--YDSPKARQEVDHHWQASGGPHIV 85

Query: 96  TLADIVKDP--VSRTPALVFEHVNNTD-FKQLY----QTLTDYDIRFYMYEILKALDYCH 148
            + D+ ++     R   ++ E +   + F ++     Q  T+ +    M +I  A+ + H
Sbjct: 86  CILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLH 145

Query: 149 SMGIMHRDVKPHNVMIDHEHRK--LRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDY 206
           S  I HRDVKP N++   + +   L+L D+G A+             + Y+  PE+L   
Sbjct: 146 SHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAK-ETTQNALQTPCYTPYYVAPEVL-GP 203

Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFF 233
           + YD S DMWSLG ++  ++    PF+
Sbjct: 204 EKYDKSCDMWSLGVIMYILLCGFPPFY 230


>3ZUT-A nrPDB
          Length = 362

 Score = 75.1 bits (183), Expect = 5e-14,   Method: Compositional matrix adjust.
 Identities = 52/204 (25%), Positives = 103/204 (50%), Gaps = 9/204 (4%)

Query: 35  NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK--KKIKREIKILENLRGGP 92
           + D Y+LV+ +G G +       +  +NE V VK ++  +K  + +KREI    +LR  P
Sbjct: 17  DSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRH-P 75

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNTD-FKQLYQT--LTDYDIRFYMYEILKALDYCHS 149
           NI+   +++  P     A+V E+ +  + F+++      ++ + RF+  +++  + YCH+
Sbjct: 76  NIVRFKEVILTPTHL--AIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHA 133

Query: 150 MGIMHRDVKPHNVMIDHEHR-KLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQM 208
           M + HRD+K  N ++D     +L++  +G ++      +    V +  +  PE+L+  + 
Sbjct: 134 MQVCHRDLKLENTLLDGSPAPRLKICAFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEY 193

Query: 209 YDYSLDMWSLGCMLASMIFRKEPF 232
                D+WS G  L  M+    PF
Sbjct: 194 DGKVADVWSCGVTLYVMLVGAYPF 217


>2GCD-A nrPDB
          Length = 309

 Score = 74.7 bits (182), Expect = 6e-14,   Method: Compositional matrix adjust.
 Identities = 58/204 (28%), Positives = 102/204 (50%), Gaps = 18/204 (8%)

Query: 42  VRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK------IKREIKILENLRGGPNII 95
           +R++G G +  V+ A ++ N+E V +K +    K+       I +E++ L+ LR  PN I
Sbjct: 20  LREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRH-PNTI 78

Query: 96  TLADIVKDPVSRTPALVFEHV--NNTDFKQLYQT-LTDYDIRFYMYEILKALDYCHSMGI 152
                       T  LV E+   + +D  ++++  L + +I    +  L+ L Y HS  +
Sbjct: 79  QYRGCYLR--EHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHSHNM 136

Query: 153 MHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLV--DYQMYD 210
           +HRDVK  N+++  E   ++L D+G A    P   +   V + Y+  PE+++  D   YD
Sbjct: 137 IHRDVKAGNILLS-EPGLVKLGDFGSASIMAPANSF---VGTPYWMAPEVILAMDEGQYD 192

Query: 211 YSLDMWSLGCMLASMIFRKEPFFH 234
             +D+WSLG     +  RK P F+
Sbjct: 193 GKVDVWSLGITCIELAERKPPLFN 216


>3LM0-A nrPDB
          Length = 327

 Score = 74.7 bits (182), Expect = 7e-14,   Method: Compositional matrix adjust.
 Identities = 51/218 (23%), Positives = 112/218 (51%), Gaps = 16/218 (7%)

Query: 43  RKLGRGKYSEVFEAINITNNEKVVVKILKPVKK-----KKIKREIKILENLRGGPNIITL 97
           ++LGRGK++ V + I+ +  ++   K LK  ++      +I  EI +LE  +  P +I L
Sbjct: 35  KELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELAKSCPRVINL 94

Query: 98  ADIVKDPVSRTPALVFEHVNNTD-----FKQLYQTLTDYDIRFYMYEILKALDYCHSMGI 152
            ++ ++  +    L+ E+    +       +L + +++ D+   + +IL+ + Y H   I
Sbjct: 95  HEVYEN--TSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQNNI 152

Query: 153 MHRDVKPHNVMIDHEH--RKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYD 210
           +H D+KP N+++   +    ++++D+G++       E    + +  +  PE+L +Y    
Sbjct: 153 VHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACELREIMGTPEYLAPEIL-NYDPIT 211

Query: 211 YSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKV 248
            + DMW++G ++A M+      F G DN +  + I++V
Sbjct: 212 TATDMWNIG-IIAYMLLTHTSPFVGEDNQETYLNISQV 248


>3HKO-A nrPDB
          Length = 345

 Score = 74.3 bits (181), Expect = 7e-14,   Method: Compositional matrix adjust.
 Identities = 85/352 (24%), Positives = 142/352 (40%), Gaps = 105/352 (29%)

Query: 36  QDDYQLVRKLGRGKYSEV----------FEAINITNNEKVVVKILKPVKKKKIKREIKIL 85
           Q  Y L   +G+G Y  V            AI I N  K+  + + P   ++IK E++++
Sbjct: 25  QKKYHLKGAIGQGSYGVVRVAIENQTRAIRAIKIMNKNKI--RQINPKDVERIKTEVRLM 82

Query: 86  ENLRGGPNIITL--------------------------------------ADIVKDPVSR 107
           + L   PNI  L                                       D+VK  +  
Sbjct: 83  KKLHH-PNIARLYEVYEDEQYICLVMELCHGGHLLDKLNVFIDDSTGKCAMDVVKTQICP 141

Query: 108 TPALVFEHVNNT--------DFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKP 159
            P    E +N +        DF Q  + +++      M +I  AL Y H+ GI HRD+KP
Sbjct: 142 CPECNEEAINGSIHGFRESLDFVQREKLISNI-----MRQIFSALHYLHNQGICHRDIKP 196

Query: 160 HNVMID-HEHRKLRLIDWGLA-EFY--HPGQEYNV--RVASRYFKGPELL-VDYQMYDYS 212
            N +   ++  +++L+D+GL+ EFY  + G+ Y +  +  + YF  PE+L    + Y   
Sbjct: 197 ENFLFSTNKSFEIKLVDFGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEVLNTTNESYGPK 256

Query: 213 LDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDI 272
            D WS G +L  ++    P F G ++ D    I++VL  +  ++         +P +N  
Sbjct: 257 CDAWSAGVLLHLLLMGAVP-FPGVNDADT---ISQVLNKKLCFE---------NPNYN-- 301

Query: 273 LGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324
                              ++SP A D L  LL  +   R  A  A++HP+ 
Sbjct: 302 -------------------VLSPLARDLLSNLLNRNVDERFDAMRALQHPWI 334


>2JAM-A nrPDB
          Length = 304

 Score = 74.3 bits (181), Expect = 8e-14,   Method: Compositional matrix adjust.
 Identities = 69/287 (24%), Positives = 127/287 (44%), Gaps = 47/287 (16%)

Query: 45  LGRGKYSEVFEAINITNNEKVVVKILK---PVKKKKIKREIKILENLRGGPNIITLADIV 101
           LG G +SEVF        +   +K +K     +   ++ EI +L+ ++   NI+TL DI 
Sbjct: 17  LGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDSSLENEIAVLKKIKH-ENIVTLEDIY 75

Query: 102 KDPVSRTPALVFEHVNNTD-FKQLYQ--TLTDYDIRFYMYEILKALDYCHSMGIMHRDVK 158
           +        LV + V+  + F ++ +    T+ D    + ++L A+ Y H  GI+HRD+K
Sbjct: 76  ESTTHYY--LVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHENGIVHRDLK 133

Query: 159 PHNV--MIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMW 216
           P N+  +   E+ K+ + D+GL++    G   +    +  +  PE+L   + Y  ++D W
Sbjct: 134 PENLLYLTPEENSKIMITDFGLSKMEQNGI-MSTACGTPGYVAPEVLAQ-KPYSKAVDCW 191

Query: 217 SLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRH 276
           S+G +   ++    PF+   ++               L++ I +   E +  F       
Sbjct: 192 SIGVITYILLCGYPPFYEETES--------------KLFEKIKEGYYEFESPF------- 230

Query: 277 SRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323
               W+          +S  A DF+  LL  D   R T  +A+ HP+
Sbjct: 231 ----WDD---------ISESAKDFICHLLEKDPNERYTCEKALSHPW 264


>6CKI-A nrPDB
          Length = 316

 Score = 74.3 bits (181), Expect = 9e-14,   Method: Compositional matrix adjust.
 Identities = 72/309 (23%), Positives = 139/309 (44%), Gaps = 42/309 (13%)

Query: 36  QDDYQLVRK-LGRGKYSEVFEAINITNNEKVVVKILKPVK---KKKIKREIKILENLRGG 91
           +D YQL    LG G ++ V   IN+  +++  VKI++      + ++ RE+++L   +G 
Sbjct: 11  EDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQCQGH 70

Query: 92  PNIITLADIVKDPVSRTPALVFEHV-NNTDFKQLYQT--LTDYDIRFYMYEILKALDYCH 148
            N++ L +  +        LVFE +   +    +++     + +    + ++  ALD+ H
Sbjct: 71  RNVLELIEFFE--EEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLH 128

Query: 149 SMGIMHRDVKPHNVMIDHEHR--KLRLIDWGLAEFYH--------PGQEYNVRVASRYFK 198
           + GI HRD+KP N++ +H ++   +++ D+GL                E      S  + 
Sbjct: 129 NKGIAHRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPELLTPCGSAEYM 188

Query: 199 GPELLVDY----QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDL 254
            PE++  +     +YD   D+WSLG +L  ++    PF                 G++  
Sbjct: 189 APEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPF-------------VGRCGSDCG 235

Query: 255 YDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT 314
           +D       E  P   ++L    ++    F   +  H +S  A D + KLL  D + RL+
Sbjct: 236 WD-----RGEACPACQNMLFESIQEGKYEFPDKDWAH-ISCAAKDLISKLLVRDAKQRLS 289

Query: 315 AREAMEHPY 323
           A + ++HP+
Sbjct: 290 AAQVLQHPW 298


>3NYO-A nrPDB
          Length = 576

 Score = 74.3 bits (181), Expect = 9e-14,   Method: Compositional matrix adjust.
 Identities = 58/195 (29%), Positives = 85/195 (43%), Gaps = 41/195 (21%)

Query: 135 FYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVAS 194
           FY  EI   L+  H   I++RD+KP N+++D +H  +R+ D GLA     GQ    RV +
Sbjct: 290 FYAAEICCGLEDLHRERIVYRDLKPENILLD-DHGHIRISDLGLAVHVPEGQTIKGRVGT 348

Query: 195 RYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDL 254
             +  PE+ V  + Y +S D W+LGC+L  MI  + PF           +  K +  E++
Sbjct: 349 VGYMAPEV-VKNERYTFSPDWWALGCLLYEMIAGQSPF----------QQRKKKIKREEV 397

Query: 255 YDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRL- 313
              + +   E   RF                        SP+A     +LL  D   RL 
Sbjct: 398 ERLVKEVPEEYSERF------------------------SPQARSLCSQLLCKDPAERLG 433

Query: 314 ----TAREAMEHPYF 324
               +ARE  EHP F
Sbjct: 434 CRGGSAREVKEHPLF 448


>1VZO-A nrPDB
          Length = 355

 Score = 73.9 bits (180), Expect = 1e-13,   Method: Compositional matrix adjust.
 Identities = 55/212 (25%), Positives = 110/212 (51%), Gaps = 19/212 (8%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKI----------KREIKILE 86
           ++++L++ LG G Y +VF    I+ ++   +  +K +KK  I          + E ++LE
Sbjct: 54  ENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLE 113

Query: 87  NLRGGPNIITLADIVKDPVSRTPALVFEHVNNTD-FKQLYQT--LTDYDIRFYMYEILKA 143
           ++R  P ++TL    +        L+ +++N  + F  L Q    T+++++ Y+ EI+ A
Sbjct: 114 HIRQSPFLVTLHYAFQTETKL--HLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLA 171

Query: 144 LDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQE--YNVRVASRYFKGP 200
           L++ H +GI++RD+K  N+++D  +  + L D+GL+ EF     E  Y+      Y    
Sbjct: 172 LEHLHKLGIIYRDIKLENILLD-SNGHVVLTDFGLSKEFVADETERAYDFCGTIEYMAPD 230

Query: 201 ELLVDYQMYDYSLDMWSLGCMLASMIFRKEPF 232
            +      +D ++D WSLG ++  ++    PF
Sbjct: 231 IVRGGDSGHDKAVDWWSLGVLMYELLTGASPF 262


>3LLT-A nrPDB
          Length = 360

 Score = 73.6 bits (179), Expect = 1e-13,   Method: Compositional matrix adjust.
 Identities = 58/246 (23%), Positives = 111/246 (45%), Gaps = 36/246 (14%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK--KKIKREIKILENLRGGPN 93
            + + ++RK+G G +  V    +I N +   VK+++ +KK  +  K E  IL+ ++    
Sbjct: 34  NNAFLVIRKMGDGTFGRVLLCQHIDNKKYYAVKVVRNIKKYTRSAKIEADILKKIQNDDI 93

Query: 94  IITLADIVKDPVSRTP--ALVFEHVNNTDFKQL----YQTLTDYDIRFYMYEILKALDYC 147
                              L+FE +  + ++ +    Y      DI+ Y  EILKAL+Y 
Sbjct: 94  NNNNIVKYHGKFMYYDHMCLIFEPLGPSLYEIITRNNYNGFHIEDIKLYCIEILKALNYL 153

Query: 148 HSMGIMHRDVKPHNVMIDHEHRK------------------------LRLIDWGLAEFYH 183
             M + H D+KP N+++D  + +                        ++LID+G A F  
Sbjct: 154 RKMSLTHTDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRTKSTGIKLIDFGCATF-- 211

Query: 184 PGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLV 243
               +   + +R ++ PE++++   +D S DMWS GC+LA + +     F  H++ + L 
Sbjct: 212 KSDYHGSIINTRQYRAPEVILNLG-WDVSSDMWSFGCVLAEL-YTGSLLFRTHEHMEHLA 269

Query: 244 RIAKVL 249
            +  ++
Sbjct: 270 MMESII 275


>6ED6-A nrPDB
          Length = 415

 Score = 73.6 bits (179), Expect = 2e-13,   Method: Compositional matrix adjust.
 Identities = 62/214 (28%), Positives = 105/214 (49%), Gaps = 25/214 (11%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKR-------EIKILENLR 89
           +DY +V+ +GRG + EV    +  + +   +K+L   K + IKR       E + +    
Sbjct: 88  EDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLS--KFEMIKRSDSAFFWEERDIMAFA 145

Query: 90  GGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDI-----RFYMYEILKAL 144
             P ++ L    +D   R   +V E++   D   L   +++YD+     +FY  E++ AL
Sbjct: 146 NSPWVVQLFYAFQD--DRYLYMVMEYMPGGDLVNL---MSNYDVPEKWAKFYTAEVVLAL 200

Query: 145 DYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEY-NVRVASRYFKGPEL 202
           D  HSMG++HRDVKP N+++D +H  L+L D+G   +    G  + +  V +  +  PE+
Sbjct: 201 DAIHSMGLIHRDVKPDNMLLD-KHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEV 259

Query: 203 LVDY---QMYDYSLDMWSLGCMLASMIFRKEPFF 233
           L        Y    D WS+G  L  M+    PF+
Sbjct: 260 LKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFY 293


>3TXO-A nrPDB
          Length = 353

 Score = 73.2 bits (178), Expect = 2e-13,   Method: Compositional matrix adjust.
 Identities = 59/206 (28%), Positives = 97/206 (47%), Gaps = 14/206 (6%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP---VKKKKIK---REIKILENLRG 90
           D+++ +R LG+G + +V  A      +   VK+LK    ++   ++    E +IL   R 
Sbjct: 23  DNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARN 82

Query: 91  GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYD---IRFYMYEILKALDYC 147
            P +  L    + P       V E VN  D     Q    +D    RFY  EI+ AL + 
Sbjct: 83  HPFLTQLFCCFQTP--DRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFL 140

Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLVDY 206
           H  GI++RD+K  NV++DHE    +L D+G+  E    G        +  +  PE+L + 
Sbjct: 141 HDKGIIYRDLKLDNVLLDHEGH-CKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQE- 198

Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPF 232
            +Y  ++D W++G +L  M+    PF
Sbjct: 199 MLYGPAVDWWAMGVLLYEMLCGHAPF 224


>3HDN-A nrPDB
          Length = 373

 Score = 73.2 bits (178), Expect = 2e-13,   Method: Compositional matrix adjust.
 Identities = 84/360 (23%), Positives = 151/360 (41%), Gaps = 67/360 (18%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL--KPVKKKKIKREIK-----ILENLRG 90
           D+  ++ +G+G + +V  A +        VK+L  K + KKK ++ I      +L+N++ 
Sbjct: 39  DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKH 98

Query: 91  GPNIITLADIVKDPVSRTPALVFEHVNNTDF---KQLYQTLTDYDIRFYMYEILKALDYC 147
            P ++ L    +   +     V +++N  +     Q  +   +   RFY  EI  AL Y 
Sbjct: 99  -PFLVGLHFSFQ--TADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYL 155

Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELL---- 203
           HS+ I++RD+KP N+++D +   + L D+GL +      E+N    S +   PE L    
Sbjct: 156 HSLNIVYRDLKPENILLDSQGH-IVLTDFGLCK---ENIEHN-STTSTFCGTPEYLAPEV 210

Query: 204 VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNI 263
           +  Q YD ++D W LG +L  M++   PF+  +              T ++YD I    +
Sbjct: 211 LHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRN--------------TAEMYDNILNKPL 256

Query: 264 ELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAR----EAM 319
           +L P                         ++  A   L+ LL+ D   RL A+    E  
Sbjct: 257 QLKPN------------------------ITNSARHLLEGLLQKDRTKRLGAKDDFMEIK 292

Query: 320 EHPYFYTVVKD---QARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLGPLAGSPVIAAA 376
            H +F  +  D     ++     P  S P    +     +  P P+ +G    S ++ A+
Sbjct: 293 SHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNAIGKAPDSVLVTAS 352


>3DB8-A nrPDB
          Length = 317

 Score = 73.2 bits (178), Expect = 2e-13,   Method: Compositional matrix adjust.
 Identities = 53/204 (25%), Positives = 109/204 (53%), Gaps = 15/204 (7%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNE----KVVVK--ILKPVKKKKIKREIKILENLRGGP 92
           Y   R LG+G +++ +E  ++   E    KVV K  +LKP +K+K+  EI I ++L   P
Sbjct: 44  YMRGRFLGKGGFAKCYEITDMDTKEVFAGKVVPKSMLLKPHQKEKMSTEIAIHKSL-DNP 102

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ---TLTDYDIRFYMYEILKALDYCHS 149
           +++      +D       +V E        +L++    +T+ + R++M + ++ + Y H+
Sbjct: 103 HVVGFHGFFED--DDFVYVVLEICRRRSLLELHKRRKAVTEPEARYFMRQTIQGVQYLHN 160

Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLVDYQM 208
             ++HRD+K  N+ ++ +   +++ D+GLA +    G+       +  +  PE+L   + 
Sbjct: 161 NRVIHRDLKLGNLFLNDDM-DVKIGDFGLATKIEFDGERKKDLCGTPNYIAPEVLCK-KG 218

Query: 209 YDYSLDMWSLGCMLASMIFRKEPF 232
           + + +D+WSLGC+L +++  K PF
Sbjct: 219 HSFEVDIWSLGCILYTLLVGKPPF 242


>4B8L-A nrPDB
          Length = 286

 Score = 72.8 bits (177), Expect = 2e-13,   Method: Compositional matrix adjust.
 Identities = 71/296 (23%), Positives = 128/296 (43%), Gaps = 53/296 (17%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL------KPVKKKKIKREIKILENLRG 90
           DD+ + R LG+GK+  V+ A    N   + +K+L      K   + +++REI+I  +LR 
Sbjct: 15  DDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRREIEIQSHLRH 74

Query: 91  GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIR---FYMYEILKALDYC 147
            PNI+ + +   D   +   L+ E     +  +  Q    +D +    +M E+  AL YC
Sbjct: 75  -PNILRMYNYFHD--RKRIYLMLEFAPRGELYKELQKHGRFDEQRSATFMEELADALHYC 131

Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQ 207
           H   ++HRD+KP N+++ ++  +L++ D+G +  + P         +  +  PE +++ +
Sbjct: 132 HERKVIHRDIKPENLLMGYKG-ELKIADFGWS-VHAPSLRRRTMCGTLDYLPPE-MIEGK 188

Query: 208 MYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDP 267
            +D  +D+W  G +    +    P F    + +   RI  V                 D 
Sbjct: 189 THDEKVDLWCAGVLCYEFLVGMPP-FDSPSHTETHRRIVNV-----------------DL 230

Query: 268 RFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323
           +F   L   S+                    D + KLLRY    RL  +  MEHP+
Sbjct: 231 KFPPFLSDGSK--------------------DLISKLLRYHPPQRLPLKGVMEHPW 266


>5D7A-A nrPDB
          Length = 308

 Score = 72.8 bits (177), Expect = 3e-13,   Method: Compositional matrix adjust.
 Identities = 73/309 (23%), Positives = 133/309 (43%), Gaps = 57/309 (18%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPV--KKKKIKREIKILENLRGGPNIIT 96
           ++LV  +G G Y +V++  ++   +   +K++     ++++IK+EI +L+      NI T
Sbjct: 19  FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIAT 78

Query: 97  L--ADIVKDP--VSRTPALVFEHVNNTDFKQLYQ-----TLTDYDIRFYMYEILKALDYC 147
              A I K+P  +     LV E         L +     TL +  I +   EIL+ L + 
Sbjct: 79  YYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHL 138

Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGL-AEFYHPGQEYNVRVASRYFKGPELLVDY 206
           H   ++HRD+K  NV++  E+ +++L+D+G+ A+        N  + + Y+  PE++   
Sbjct: 139 HQHKVIHRDIKGQNVLLT-ENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACD 197

Query: 207 Q----MYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYN 262
           +     YD+  D+WSLG                      +  I    G   L D      
Sbjct: 198 ENPDATYDFKSDLWSLG----------------------ITAIEMAEGAPPLCDMHPMRA 235

Query: 263 IELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHP 322
           + L PR  +   R   K+W +   S            F++  L  +H  R    + M+HP
Sbjct: 236 LFLIPR--NPAPRLKSKKWSKKFQS------------FIESCLVKNHSQRPATEQLMKHP 281

Query: 323 YFYTVVKDQ 331
           +    ++DQ
Sbjct: 282 F----IRDQ 286


>3DLS-A nrPDB
          Length = 335

 Score = 72.4 bits (176), Expect = 3e-13,   Method: Compositional matrix adjust.
 Identities = 61/224 (27%), Positives = 103/224 (45%), Gaps = 27/224 (12%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK-----------KKIKREIKILEN 87
           Y  +  LG G +  V+ A++   N++VVVK +K  K             K+  EI IL  
Sbjct: 26  YSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSR 85

Query: 88  LRGGPNIITLADIVKDPVSRTPALVFE-HVNNTDF-------KQLYQTLTDYDIRFYMYE 139
           +    NII + DI ++       LV E H +  D         +L + L  Y  R    +
Sbjct: 86  VEHA-NIIKVLDIFEN--QGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASYIFR----Q 138

Query: 140 ILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKG 199
           ++ A+ Y     I+HRD+K  N++I  E   ++LID+G A +   G+ +     +  +  
Sbjct: 139 LVSAVGYLRLKDIIHRDIKDENIVI-AEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCA 197

Query: 200 PELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLV 243
           PE+L+        L+MWSLG  L +++F + PF    +  +  +
Sbjct: 198 PEVLMGNPYRGPELEMWSLGVTLYTLVFEENPFCELEETVEAAI 241


>3UDB-A nrPDB
          Length = 317

 Score = 72.0 bits (175), Expect = 4e-13,   Method: Compositional matrix adjust.
 Identities = 52/204 (25%), Positives = 102/204 (50%), Gaps = 9/204 (4%)

Query: 35  NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK--KKIKREIKILENLRGGP 92
           + D Y+LV+ +G G +       +   NE V VK ++  +K  + +KREI    +LR  P
Sbjct: 17  DSDRYELVKDIGAGNFGVARLMRDKQANELVAVKYIERGEKIDENVKREIINHRSLRH-P 75

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNTD-FKQLYQT--LTDYDIRFYMYEILKALDYCHS 149
           NI+   +++  P     A+V E+ +  + F+++      ++ + RF+  +++  + Y H+
Sbjct: 76  NIVRFKEVILTPTHL--AIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYAHA 133

Query: 150 MGIMHRDVKPHNVMIDHEHR-KLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQM 208
           M + HRD+K  N ++D     +L++ D+G ++      +    V +  +  PE+L+  + 
Sbjct: 134 MQVAHRDLKLENTLLDGSPAPRLKIADFGYSKASVLHSQPKSAVGTPAYIAPEVLLKKEY 193

Query: 209 YDYSLDMWSLGCMLASMIFRKEPF 232
                D+WS G  L  M+    PF
Sbjct: 194 DGKVADVWSCGVTLYVMLVGAYPF 217


>5F9E-A nrPDB
          Length = 353

 Score = 72.0 bits (175), Expect = 4e-13,   Method: Compositional matrix adjust.
 Identities = 57/213 (26%), Positives = 102/213 (47%), Gaps = 19/213 (8%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIIT 96
           +D++L + LG+G + +VF A     N+   +K LK    K +      +E       +++
Sbjct: 19  EDFELHKMLGKGSFGKVFLAEFKKTNQFFAIKALK----KDVVLMDDDVECTMVEKRVLS 74

Query: 97  LA--------DIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIR---FYMYEILKALD 145
           LA                     V E++N  D     Q+   +D+    FY  EI+  L 
Sbjct: 75  LAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQ 134

Query: 146 YCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ-EYNVRVASRYFKGPELLV 204
           + HS GI++RD+K  N+++D +   +++ D+G+ +    G  + N    +  +  PE+L+
Sbjct: 135 FLHSKGIVYRDLKLDNILLDKDGH-IKIADFGMCKENMLGDAKTNEFCGTPDYIAPEILL 193

Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHD 237
             Q Y++S+D WS G +L  M+  + P FHG D
Sbjct: 194 G-QKYNHSVDWWSFGVLLYEMLIGQSP-FHGQD 224


>4FIE-A nrPDB
          Length = 423

 Score = 71.6 bits (174), Expect = 5e-13,   Method: Compositional matrix adjust.
 Identities = 52/198 (26%), Positives = 85/198 (42%), Gaps = 38/198 (19%)

Query: 128 LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGL-AEFYHPGQ 186
           + +  I      +L+AL   H+ G++HRD+K  ++++ H+ R ++L D+G  A+      
Sbjct: 244 MNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGR-VKLSDFGFCAQVSKEVP 302

Query: 187 EYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIA 246
                V + Y+  PEL+     Y   +D+WSLG M+  M+  + P+F+            
Sbjct: 303 RRKSLVGTPYWMAPELISRLP-YGPEVDIWSLGIMVIEMVDGEPPYFN------------ 349

Query: 247 KVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLR 306
                E     +      L PR                   +N H VSP    FLD+LL 
Sbjct: 350 -----EPPLKAMKMIRDNLPPRL------------------KNLHKVSPSLKGFLDRLLV 386

Query: 307 YDHQSRLTAREAMEHPYF 324
            D   R TA E ++HP+ 
Sbjct: 387 RDPAQRATAAELLKHPFL 404


>3Q53-A nrPDB
          Length = 306

 Score = 71.6 bits (174), Expect = 5e-13,   Method: Compositional matrix adjust.
 Identities = 67/294 (22%), Positives = 131/294 (44%), Gaps = 50/294 (17%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVK---ILKPVKKKKIKREIKILENLRGGPNII 95
           Y    K+G+G    V+ A+++   ++V ++   + +  KK+ I  EI ++   +  PNI+
Sbjct: 23  YTRFEKIGQGASGTVYTAMDVATGQEVAIRQMNLQQQPKKELIINEILVMRENKN-PNIV 81

Query: 96  TLAD--IVKDPVSRTPALVFEHVNNTDFKQLYQ--TLTDYDIRFYMYEILKALDYCHSMG 151
              D  +V D +     +V E++       +     + +  I     E L+AL++ HS  
Sbjct: 82  NYLDSYLVGDEL----WVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQ 137

Query: 152 IMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ-EYNVRVASRYFKGPELLVDYQMYD 210
           ++HRD+K  N+++  +   ++L D+G      P Q + +  V + Y+  PE +V  + Y 
Sbjct: 138 VIHRDIKSDNILLGMDG-SVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPE-VVTRKAYG 195

Query: 211 YSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFN 270
             +D+WSLG M   MI  + P+   ++N  + + +    GT +L                
Sbjct: 196 PKVDIWSLGIMAIEMIEGEPPYL--NENPLRALYLIATNGTPEL---------------- 237

Query: 271 DILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324
                            +N   +S    DFL++ L  D + R +A+E ++H + 
Sbjct: 238 -----------------QNPEKLSAIFRDFLNRCLEMDVEKRGSAKELIQHQFL 274


>6E9W-A nrPDB
          Length = 443

 Score = 71.6 bits (174), Expect = 6e-13,   Method: Compositional matrix adjust.
 Identities = 64/216 (29%), Positives = 103/216 (47%), Gaps = 29/216 (13%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKR-------EIKILENLR 89
           +DY++V+ +GRG + EV    + +  +   +K+L   K + IKR       E + +    
Sbjct: 102 EDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLS--KFEMIKRSDSAFFWEERDIMAFA 159

Query: 90  GGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDI-----RFYMYEILKAL 144
             P ++ L    +D   R   +V E++   D   L   +++YD+     RFY  E++ AL
Sbjct: 160 NSPWVVQLFYAFQD--DRYLYMVMEYMPGGDLVNL---MSNYDVPEKWARFYTAEVVLAL 214

Query: 145 DYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVR----VASRYFKGP 200
           D  HSMG +HRDVKP N+++D     L+L D+G        +E  VR    V +  +  P
Sbjct: 215 DAIHSMGFIHRDVKPDNMLLDKSGH-LKLADFGTC--MKMNKEGMVRCDTAVGTPDYISP 271

Query: 201 ELLVDY---QMYDYSLDMWSLGCMLASMIFRKEPFF 233
           E+L        Y    D WS+G  L  M+    PF+
Sbjct: 272 EVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFY 307


>3ORP-A nrPDB
          Length = 311

 Score = 71.2 bits (173), Expect = 7e-13,   Method: Compositional matrix adjust.
 Identities = 58/213 (27%), Positives = 100/213 (46%), Gaps = 20/213 (9%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK------PVKKKKIKREIKILENLR 89
            D Y+L   LG G  SEV  A ++ ++  V VK+L+      P    + +RE +    L 
Sbjct: 11  SDRYELGEILGFGGMSEVHLARDLRDHRDVAVKVLRADLARDPSFYLRFRREAQNAAALN 70

Query: 90  GGPNIITLADI--VKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKAL 144
             P I+ + D    + P    P +V E+V+    + +  T   +T       + +  +AL
Sbjct: 71  H-PAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIVHTEGPMTPKRAIEVIADACQAL 129

Query: 145 DYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPG-----QEYNVRVASRYFKG 199
           ++ H  GI+HRDVKP N+MI   +  ++++D+G+A           Q   V   ++Y   
Sbjct: 130 NFSHQNGIIHRDVKPANIMISATN-AVKVMDFGIARAIADSGNSVTQTAAVIGTAQYLSP 188

Query: 200 PELLVDYQMYDYSLDMWSLGCMLASMIFRKEPF 232
            +   D    D   D++SLGC+L  ++  + PF
Sbjct: 189 EQARGDS--VDARSDVYSLGCVLYEVLTGEPPF 219


>3QA8-A nrPDB
          Length = 676

 Score = 71.2 bits (173), Expect = 7e-13,   Method: Compositional matrix adjust.
 Identities = 57/212 (26%), Positives = 100/212 (47%), Gaps = 20/212 (9%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKI----LKPVKKKKIKREIKILENLRGGPNI 94
           +++  +LG G +  V   I+    E+V +K     L P  +++   EI+I++ L   PN+
Sbjct: 16  WEMKERLGTGGFGYVLRWIHQDTGEQVAIKQCRQELSPKNRERWCLEIQIMKKL-NHPNV 74

Query: 95  ITLADIVKDPVSRT-----PALVFEHVNNTDFKQLYQT------LTDYDIRFYMYEILKA 143
           ++ A  V D + +      P L  E+    D ++          L +  IR  + +I  A
Sbjct: 75  VS-AREVPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGPIRTLLSDISSA 133

Query: 144 LDYCHSMGIMHRDVKPHNVMIDHEHRKL--RLIDWGLAEFYHPGQEYNVRVASRYFKGPE 201
           L Y H   I+HRD+KP N+++    ++L  ++ID G A+    G+     V +  +  PE
Sbjct: 134 LRYLHENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQGELCTEFVGTLQYLAPE 193

Query: 202 LLVDYQMYDYSLDMWSLGCMLASMIFRKEPFF 233
           LL + + Y  ++D WS G +    I    PF 
Sbjct: 194 LL-EQKKYTVTVDYWSFGTLAFECITGFRPFL 224


>4TNB-A nrPDB
          Length = 590

 Score = 70.9 bits (172), Expect = 9e-13,   Method: Compositional matrix adjust.
 Identities = 72/262 (27%), Positives = 123/262 (46%), Gaps = 28/262 (10%)

Query: 35  NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKR---------EIKIL 85
            ++ ++  R LG+G + EV  A  +    K+     K ++KK+IK+         E +IL
Sbjct: 182 TKNTFRQYRVLGKGGFGEVC-ACQVRATGKMYA--CKRLEKKRIKKRKGESMALNEKQIL 238

Query: 86  ENLRGGPNIITLADI--VKDPVSRTPALVFEHVNNTDFK-QLYQT----LTDYDIRFYMY 138
           E +     ++ LA     KD +     LV   +N  D K  +Y        +    FY  
Sbjct: 239 EKV-NSQFVVNLAYAYETKDAL----CLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAA 293

Query: 139 EILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFK 198
           EIL  L+  H    ++RD+KP N+++D ++  +R+ D GLA     G     RV +  + 
Sbjct: 294 EILCGLEDLHHENTVYRDLKPENILLD-DYGHIRISDLGLAVKIPEGDLIRGRVGTVGYM 352

Query: 199 GPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYI 258
            PE+L + Q Y  S D W LGC++  MI  + PF    +   +     +VL TE++Y + 
Sbjct: 353 APEVL-NNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSH- 410

Query: 259 DKYNIELDPRFNDILGRHSRKR 280
            K++ E       +L + +++R
Sbjct: 411 -KFSEEAKSICKMLLTKDAKQR 431


>4JDH-A nrPDB
          Length = 346

 Score = 70.5 bits (171), Expect = 1e-12,   Method: Compositional matrix adjust.
 Identities = 52/198 (26%), Positives = 85/198 (42%), Gaps = 38/198 (19%)

Query: 128 LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGL-AEFYHPGQ 186
           + +  I      +L+AL   H+ G++HRD+K  ++++ H+ R ++L D+G  A+      
Sbjct: 167 MNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGR-VKLSDFGFCAQVSKEVP 225

Query: 187 EYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIA 246
                V + Y+  PEL+     Y   +D+WSLG M+  M+  + P+F+            
Sbjct: 226 RRKSLVGTPYWMAPELISRLP-YGPEVDIWSLGIMVIEMVDGEPPYFN------------ 272

Query: 247 KVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLR 306
                E     +      L PR                   +N H VSP    FLD+LL 
Sbjct: 273 -----EPPLKAMKMIRDNLPPRL------------------KNLHKVSPSLKGFLDRLLV 309

Query: 307 YDHQSRLTAREAMEHPYF 324
            D   R TA E ++HP+ 
Sbjct: 310 RDPAQRATAAELLKHPFL 327


>6HXF-B nrPDB
          Length = 302

 Score = 70.5 bits (171), Expect = 1e-12,   Method: Compositional matrix adjust.
 Identities = 75/304 (24%), Positives = 138/304 (45%), Gaps = 47/304 (15%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKR---EIKILENLRGGPNII 95
           +++V +LG G + +V++A N         K+++   +++++    EI+IL      P I+
Sbjct: 21  WEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATC-DHPYIV 79

Query: 96  TLADIVKDPVSRTPALVFEHVNNTD--FKQLYQTLTDYDIRFYMYEILKALDYCHSMGIM 153
            L             + F      D    +L + LT+  I+    ++L+AL++ HS  I+
Sbjct: 80  KLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKRII 139

Query: 154 HRDVKPHNVMIDHEHRKLRLIDWGL-AEFYHPGQEYNVRVASRYFKGPELLVDYQM---- 208
           HRD+K  NV++  E   +RL D+G+ A+     Q+ +  + + Y+  PE+++   M    
Sbjct: 140 HRDLKAGNVLMTLEG-DIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTP 198

Query: 209 YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPR 268
           YDY  D+WSLG  L  M  + EP  H  +    L++IAK                     
Sbjct: 199 YDYKADIWSLGITLIEMA-QIEPPHHELNPMRVLLKIAK--------------------- 236

Query: 269 FNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVV 328
            +D     +  +W            S E  DFL   L  + ++R +A + +EHP+  ++ 
Sbjct: 237 -SDPPTLLTPSKW------------SVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSIT 283

Query: 329 KDQA 332
            ++A
Sbjct: 284 SNKA 287


>1FOT-A nrPDB
          Length = 318

 Score = 70.1 bits (170), Expect = 1e-12,   Method: Compositional matrix adjust.
 Identities = 53/204 (25%), Positives = 106/204 (51%), Gaps = 14/204 (6%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP---VKKKKIK--REIKILENLRGGP 92
           D+Q++R LG G +  V    +  N     +K+LK    V+ K+++   + +++ ++   P
Sbjct: 7   DFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTHP 66

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCHS 149
            II +    +D  ++   ++ +++   +   L    Q   +   +FY  E+  AL+Y HS
Sbjct: 67  FIIRMWGTFQD--AQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYLHS 124

Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMY 209
             I++RD+KP N+++D ++  +++ D+G A+ Y P   Y +     Y   PE +V  + Y
Sbjct: 125 KDIIYRDLKPENILLD-KNGHIKITDFGFAK-YVPDVTYTLCGTPDYI-APE-VVSTKPY 180

Query: 210 DYSLDMWSLGCMLASMIFRKEPFF 233
           + S+D WS G ++  M+    PF+
Sbjct: 181 NKSIDWWSFGILIYEMLAGYTPFY 204


>4AF3-A nrPDB
          Length = 292

 Score = 70.1 bits (170), Expect = 1e-12,   Method: Compositional matrix adjust.
 Identities = 64/243 (26%), Positives = 125/243 (51%), Gaps = 23/243 (9%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL------KPVKKKKIKREIKILENLRG 90
           DD+++ R LG+GK+  V+ A    ++  V +K+L      K   + +++REI+I  +L  
Sbjct: 23  DDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHH 82

Query: 91  GPNIITLADIVKDPVSRTPALVFEHVNNTD-FKQLYQTLTDYDIRF--YMYEILKALDYC 147
            PNI+ L +   D   R   L+ E+    + +K+L ++ T  + R    M E+  AL YC
Sbjct: 83  -PNILRLYNYFYD--RRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYC 139

Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQ 207
           H   ++HRD+KP N+++     +L++ D+G +  + P         +  +  PE +++ +
Sbjct: 140 HGKKVIHRDIKPENLLLG-LKGELKIADFGWS-VHAPSLRRKTMCGTLDYLPPE-MIEGR 196

Query: 208 MYDYSLDMWSLGCMLASMIFRKEPFFHGHDN--YDQLVRI-----AKV-LGTEDLYDYID 259
           M++  +D+W +G +   ++    PF     N  Y ++V++     A V  G +DL   + 
Sbjct: 197 MHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPTGAQDLISKLL 256

Query: 260 KYN 262
           ++N
Sbjct: 257 RHN 259


>4KIK-B nrPDB
          Length = 677

 Score = 70.1 bits (170), Expect = 2e-12,   Method: Compositional matrix adjust.
 Identities = 54/211 (25%), Positives = 94/211 (44%), Gaps = 18/211 (8%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKI----LKPVKKKKIKREIKILENLRGGPNI 94
           +++  +LG G +  V    N    E++ +K     L P  +++   EI+I+  L   PN+
Sbjct: 21  WEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQIMRRL-THPNV 79

Query: 95  ITLADIVKDPVSRTP----ALVFEHVNNTDFKQLYQT------LTDYDIRFYMYEILKAL 144
           +   D+ +   +  P     L  E+    D ++          L +  I   + +I  AL
Sbjct: 80  VAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASAL 139

Query: 145 DYCHSMGIMHRDVKPHNVMIDHEHRKL--RLIDWGLAEFYHPGQEYNVRVASRYFKGPEL 202
            Y H   I+HRD+KP N+++    ++L  ++ID G A+    G      V +  +  PEL
Sbjct: 140 RYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPEL 199

Query: 203 LVDYQMYDYSLDMWSLGCMLASMIFRKEPFF 233
           L + Q Y  ++D WS G +    I    PF 
Sbjct: 200 L-EQQKYTVTVDYWSFGTLAFECITGFRPFL 229


>2Q0N-A nrPDB
          Length = 301

 Score = 70.1 bits (170), Expect = 2e-12,   Method: Compositional matrix adjust.
 Identities = 52/198 (26%), Positives = 85/198 (42%), Gaps = 38/198 (19%)

Query: 128 LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGL-AEFYHPGQ 186
           + +  I      +L+AL   H+ G++HRD+K  ++++ H+ R ++L D+G  A+      
Sbjct: 122 MNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGR-VKLSDFGFCAQVSKEVP 180

Query: 187 EYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIA 246
                V + Y+  PE L+    Y   +D+WSLG M+  M+  + P+F+            
Sbjct: 181 RRKSLVGTPYWMAPE-LISRLPYGPEVDIWSLGIMVIEMVDGEPPYFN------------ 227

Query: 247 KVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLR 306
                E     +      L PR                   +N H VSP    FLD+LL 
Sbjct: 228 -----EPPLKAMKMIRDNLPPRL------------------KNLHKVSPSLKGFLDRLLV 264

Query: 307 YDHQSRLTAREAMEHPYF 324
            D   R TA E ++HP+ 
Sbjct: 265 RDPAQRATAAELLKHPFL 282


>6DBM-A nrPDB
          Length = 318

 Score = 69.7 bits (169), Expect = 2e-12,   Method: Compositional matrix adjust.
 Identities = 57/199 (28%), Positives = 97/199 (48%), Gaps = 17/199 (8%)

Query: 42  VRKLGRGKYSEV----FEAINITNNEKVVVKILK----PVKKKKIKREIKILENLRGGPN 93
           +R LG G + +V    ++  N    E V VK LK    P  +   K+EI IL  L    +
Sbjct: 36  IRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAGPQHRSGWKQEIDILRTLYH-EH 94

Query: 94  IITLADIVKDPVSRTPALVFEHVNNTDFKQLY--QTLTDYDIRFYMYEILKALDYCHSMG 151
           II      +D  + +  LV E+V     +      ++    +  +  +I + + Y HS  
Sbjct: 95  IIKYKGCCEDAGAASLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHSQH 154

Query: 152 IMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE-YNVRV---ASRYFKGPELLVDYQ 207
            +HRD+   NV++D++ R +++ D+GLA+    G E Y VR    +  ++  PE L +Y+
Sbjct: 155 YIHRDLAARNVLLDND-RLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYK 213

Query: 208 MYDYSLDMWSLGCMLASMI 226
            Y Y+ D+WS G  L  ++
Sbjct: 214 FY-YASDVWSFGVTLYELL 231


>2OU7-A nrPDB
          Length = 335

 Score = 69.7 bits (169), Expect = 2e-12,   Method: Compositional matrix adjust.
 Identities = 51/198 (25%), Positives = 106/198 (53%), Gaps = 15/198 (7%)

Query: 45  LGRGKYSEVFEAINITNNE----KVVVK--ILKPVKKKKIKREIKILENLRGGPNIITLA 98
           LG+G +++ FE  +    E    K+V K  +LKP +++K+  EI I  +L    +++   
Sbjct: 49  LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSL-AHQHVVGFH 107

Query: 99  DIVKDPVSRTPALVFEHVNNTDFKQLYQ---TLTDYDIRFYMYEILKALDYCHSMGIMHR 155
              +D  +    +V E        +L++    LT+ + R+Y+ +I+    Y H   ++HR
Sbjct: 108 GFFED--NDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHR 165

Query: 156 DVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLD 214
           D+K  N+ ++ E  ++++ D+GLA +  + G+   V   +  +  PE+L   + + + +D
Sbjct: 166 DLKLGNLFLN-EDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVL-SKKGHSFEVD 223

Query: 215 MWSLGCMLASMIFRKEPF 232
           +WS+GC++ +++  K PF
Sbjct: 224 VWSIGCIMYTLLVGKPPF 241


>2JDO-A nrPDB
          Length = 342

 Score = 69.7 bits (169), Expect = 2e-12,   Method: Compositional matrix adjust.
 Identities = 74/309 (23%), Positives = 132/309 (42%), Gaps = 60/309 (19%)

Query: 35  NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP---VKKKKIKR---EIKILENL 88
             +D+  ++ LG+G + +V             +KIL+    + K ++     E ++L+N 
Sbjct: 8   TMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNT 67

Query: 89  RGGPNIITLADIVKDPVSRTPALVFEHVNNTD-FKQLYQ--TLTDYDIRFYMYEILKALD 145
           R  P +  L    +         V E+ N  + F  L +    T+   RFY  EI+ AL+
Sbjct: 68  RH-PFLTALKYAFQ--THDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALE 124

Query: 146 YCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLV 204
           Y HS  +++RD+K  N+M+D +   +++ D+GL  E    G        +  +  PE+L 
Sbjct: 125 YLHSRDVVYRDIKLENLMLDKDGH-IKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLE 183

Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPFF-HGHDNYDQLVRIAKVLGTEDLYDYIDKYNI 263
           D   Y  ++D W LG ++  M+  + PF+   H+   +L+ + ++               
Sbjct: 184 DND-YGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEI--------------- 227

Query: 264 ELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRL-----TAREA 318
                              RF  +     +SPEA   L  LL+ D + RL      A+E 
Sbjct: 228 -------------------RFPRT-----LSPEAKSLLAGLLKKDPKQRLGGGPSDAKEV 263

Query: 319 MEHPYFYTV 327
           MEH +F ++
Sbjct: 264 MEHRFFLSI 272


>4QMW-A nrPDB
          Length = 310

 Score = 69.3 bits (168), Expect = 2e-12,   Method: Compositional matrix adjust.
 Identities = 57/200 (28%), Positives = 98/200 (49%), Gaps = 13/200 (6%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKIL----KPVKKKKIKREIKILENLRGGPNI 94
           +  + K+G+G + EVF+ I+    + V +KI+       + + I++EI +L         
Sbjct: 31  FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVT 90

Query: 95  ITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT--LTDYDIRFYMYEILKALDYCHSMGI 152
                 +KD       ++ E++       L +   L +  I   + EILK LDY HS   
Sbjct: 91  KYYGSYLKD---TKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLHSEKK 147

Query: 153 MHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ-EYNVRVASRYFKGPELLVDYQMYDY 211
           +HRD+K  NV++  EH +++L D+G+A      Q + N  V + ++  PE ++    YD 
Sbjct: 148 IHRDIKAANVLLS-EHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPE-VIKQSAYDS 205

Query: 212 SLDMWSLGCMLASMIFRKEP 231
             D+WSLG + A  + R EP
Sbjct: 206 KADIWSLG-ITAIELARGEP 224


>6CQF-A nrPDB
          Length = 297

 Score = 69.3 bits (168), Expect = 3e-12,   Method: Compositional matrix adjust.
 Identities = 59/216 (27%), Positives = 105/216 (48%), Gaps = 25/216 (11%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK---KKIKREIKILENLRGGP 92
           +D Y L+++LG G Y EVF+A +  + + V +K++K         +++EI IL+  R   
Sbjct: 15  RDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRH-- 72

Query: 93  NIITLADIVKDPVS----RTPALVFEHVNNTDFKQLYQ---TLTDYDIRFYMYEILKALD 145
                A+IV    S    +   +  E       + +YQ   +L++  I +   E+L+ L 
Sbjct: 73  -----ANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLA 127

Query: 146 YCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVA---SRYFKGPEL 202
           Y HS   +HRD+K  N++I+ +  ++RL D+G++     G     R+A   + Y+  PE+
Sbjct: 128 YLHSQKKIHRDIKGANILIN-DAGEVRLADFGISA--QIGATLARRLAFIGTPYWMAPEV 184

Query: 203 --LVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGH 236
             +     Y+   D+WSLG     +   + P F  H
Sbjct: 185 AAVALKGGYNELCDIWSLGITAIELAELQPPLFDVH 220


>4KS7-A nrPDB
          Length = 292

 Score = 69.3 bits (168), Expect = 3e-12,   Method: Compositional matrix adjust.
 Identities = 53/198 (26%), Positives = 91/198 (45%), Gaps = 38/198 (19%)

Query: 128 LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGL-AEFYHPGQ 186
           L +  I      +L+AL Y H+ G++HRD+K  ++++  + R ++L D+G  A+      
Sbjct: 116 LNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGR-VKLSDFGFCAQISKDVP 174

Query: 187 EYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIA 246
           +    V + Y+  PE ++   +Y   +D+WSLG M+  M+  + P+F      D  V+  
Sbjct: 175 KRKSLVGTPYWMAPE-VISRSLYATEVDIWSLGIMVIEMVDGEPPYFS-----DSPVQAM 228

Query: 247 KVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLR 306
           K L                 P+                   +N H VSP   DFL+++L 
Sbjct: 229 KRLRDSP------------PPKL------------------KNSHKVSPVLRDFLERMLV 258

Query: 307 YDHQSRLTAREAMEHPYF 324
            D Q R TA+E ++HP+ 
Sbjct: 259 RDPQERATAQELLDHPFL 276


>4J52-A nrPDB
          Length = 293

 Score = 68.9 bits (167), Expect = 3e-12,   Method: Compositional matrix adjust.
 Identities = 51/198 (25%), Positives = 106/198 (53%), Gaps = 15/198 (7%)

Query: 45  LGRGKYSEVFEAINITNNE----KVVVK--ILKPVKKKKIKREIKILENLRGGPNIITLA 98
           LG+G +++ FE  +    E    K+V K  +LKP +++K+  EI I  +L    +++   
Sbjct: 22  LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSL-AHQHVVGFH 80

Query: 99  DIVKDPVSRTPALVFEHVNNTDFKQLYQ---TLTDYDIRFYMYEILKALDYCHSMGIMHR 155
              +D  +    +V E        +L++    LT+ + R+Y+ +I+    Y H   ++HR
Sbjct: 81  GFFED--NDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHR 138

Query: 156 DVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLD 214
           D+K  N+ ++ E  ++++ D+GLA +  + G+   V   +  +  PE+L   + + + +D
Sbjct: 139 DLKLGNLFLN-EDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVL-SKKGHSFEVD 196

Query: 215 MWSLGCMLASMIFRKEPF 232
           +WS+GC++ +++  K PF
Sbjct: 197 VWSIGCIMYTLLVGKPPF 214


>4OLI-A nrPDB
          Length = 645

 Score = 68.9 bits (167), Expect = 4e-12,   Method: Compositional matrix adjust.
 Identities = 59/220 (26%), Positives = 105/220 (47%), Gaps = 17/220 (7%)

Query: 42  VRKLGRGKYSEV----FEAINITNNEKVVVKILK----PVKKKKIKREIKILENLRGGPN 93
           +R LG G + +V    ++  N    E V VK LK    P  +   K+EI IL  L    +
Sbjct: 358 IRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYH-EH 416

Query: 94  IITLADIVKDPVSRTPALVFEHVNNTDFKQLY--QTLTDYDIRFYMYEILKALDYCHSMG 151
           II      +D   ++  LV E+V     +      ++    +  +  +I + + Y HS  
Sbjct: 417 IIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHSQH 476

Query: 152 IMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE-YNVRV---ASRYFKGPELLVDYQ 207
            +HR++   NV++D++ R +++ D+GLA+    G E Y VR    +  ++  PE L +Y+
Sbjct: 477 YIHRNLAARNVLLDND-RLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYK 535

Query: 208 MYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAK 247
            Y Y+ D+WS G  L  ++   +        + +L+ IA+
Sbjct: 536 FY-YASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQ 574


>6BDL-A nrPDB
          Length = 347

 Score = 68.6 bits (166), Expect = 5e-12,   Method: Compositional matrix adjust.
 Identities = 53/206 (25%), Positives = 103/206 (50%), Gaps = 17/206 (8%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEK--VVVKILK------PVKKKKIKREIKILENLR 89
           D+ ++  LG G +  V E + + + E     +KILK        +++ I+ E +I++   
Sbjct: 35  DFNIIDTLGVGGFGRV-ELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAH 93

Query: 90  GGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ---TLTDYDIRFYMYEILKALDY 146
               I+ L    KD  S+   ++ E     +   + +   +  D   RFY   +++A  Y
Sbjct: 94  S-DFIVRLYRTFKD--SKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAY 150

Query: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDY 206
            HS GI++RD+KP N+++DH     +L+D+G A+    G++      +  +  PE++++ 
Sbjct: 151 LHSKGIIYRDLKPENLILDHRGYA-KLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILN- 208

Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPF 232
           + +D S D WSLG ++  ++    PF
Sbjct: 209 KGHDISADYWSLGILMYELLTGSPPF 234


>4XBR-A nrPDB
          Length = 366

 Score = 68.6 bits (166), Expect = 5e-12,   Method: Compositional matrix adjust.
 Identities = 52/198 (26%), Positives = 85/198 (42%), Gaps = 38/198 (19%)

Query: 128 LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGL-AEFYHPGQ 186
           + +  I      +L+AL   H+ G++HRD+K  ++++ H+ R ++L D+G  A+      
Sbjct: 187 MNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGR-VKLSDFGFCAQVSKEVP 245

Query: 187 EYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIA 246
                V + Y+  PE L+    Y   +D+WSLG M+  M+  + P+F+            
Sbjct: 246 RRKSLVGTPYWMAPE-LISRLPYGPEVDIWSLGIMVIEMVDGEPPYFN------------ 292

Query: 247 KVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLR 306
                E     +      L PR                   +N H VSP    FLD+LL 
Sbjct: 293 -----EPPLKAMKMIRDNLPPRL------------------KNLHKVSPSLKGFLDRLLV 329

Query: 307 YDHQSRLTAREAMEHPYF 324
            D   R TA E ++HP+ 
Sbjct: 330 RDPAQRATAAELLKHPFL 347


>4EQM-A nrPDB
          Length = 294

 Score = 68.2 bits (165), Expect = 6e-12,   Method: Compositional matrix adjust.
 Identities = 61/218 (27%), Positives = 105/218 (48%), Gaps = 20/218 (9%)

Query: 28  SHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL------KPVKKKKIKRE 81
           SH++     + Y++V KLG G  S V+ A +   N KV +K +      K    K+ +RE
Sbjct: 2   SHMIGKIINERYKIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETLKRFERE 61

Query: 82  IKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----LTDYDIRFYM 137
           +     L    NI+++ D+  D       LV E++      +  ++      D  I F  
Sbjct: 62  VHNSSQL-SHQNIVSMIDV--DEEDDCYYLVMEYIEGPTLSEYIESHGPLSVDTAINF-T 117

Query: 138 YEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHP---GQEYNVRVAS 194
            +IL  + + H M I+HRD+KP N++ID  ++ L++ D+G+A+        Q  +V    
Sbjct: 118 NQILDGIKHAHDMRIVHRDIKPQNILID-SNKTLKIFDFGIAKALSETSLTQTNHVLGTV 176

Query: 195 RYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPF 232
           +YF  PE     +  D   D++S+G +L  M+  + PF
Sbjct: 177 QYF-SPE-QAKGEATDECTDIYSIGIVLYEMLVGEPPF 212


>2XNP-A nrPDB
          Length = 279

 Score = 68.2 bits (165), Expect = 6e-12,   Method: Compositional matrix adjust.
 Identities = 56/215 (26%), Positives = 99/215 (46%), Gaps = 23/215 (10%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVV------KILKPVKKKKIKREIKILENLRG 90
           +DY+++  +G G Y    + I   ++ K++V        +   +K+ +  E+ +L  L+ 
Sbjct: 6   EDYEVLYTIGTGSYGRC-QKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKH 64

Query: 91  GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY-------QTLTDYDIRFYMYEILKA 143
            PNI+   D + D  + T  +V E+    D   +        Q L +  +   M ++  A
Sbjct: 65  -PNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLA 123

Query: 144 LDYCHSMG-----IMHRDVKPHNVMIDHEHRKLRLIDWGLAEFY-HPGQEYNVRVASRYF 197
           L  CH        ++HRD+KP NV +D +   ++L D+GLA    H        V + Y+
Sbjct: 124 LKECHRRSDGGHTVLHRDLKPANVFLDGKQ-NVKLGDFGLARILNHDTSFAKTFVGTPYY 182

Query: 198 KGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPF 232
             PE + +   Y+   D+WSLGC+L  +     PF
Sbjct: 183 MSPEQM-NRMSYNEKSDIWSLGCLLYELCALMPPF 216


>3DAK-A nrPDB
          Length = 290

 Score = 67.4 bits (163), Expect = 1e-11,   Method: Compositional matrix adjust.
 Identities = 55/217 (25%), Positives = 102/217 (47%), Gaps = 21/217 (9%)

Query: 35  NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK----KIKREIKILENLRG 90
           N+DDY+L   +G G  + V  A      EKV +K +   K +    ++ +EI+ +     
Sbjct: 8   NRDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCHH 67

Query: 91  GPNIIT--LADIVKDPVSRTPAL-----VFEHVNNTDFKQLYQT--LTDYDIRFYMYEIL 141
            PNI++   + +VKD +     L     V + + +   K  +++  L +  I   + E+L
Sbjct: 68  -PNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVL 126

Query: 142 KALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKG-- 199
           + L+Y H  G +HRDVK  N+++  E   +++ D+G++ F   G +       + F G  
Sbjct: 127 EGLEYLHKNGQIHRDVKAGNILLG-EDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTP 185

Query: 200 ----PELLVDYQMYDYSLDMWSLGCMLASMIFRKEPF 232
               PE++   + YD+  D+WS G     +     P+
Sbjct: 186 CWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPY 222


>1ZXE-A nrPDB
          Length = 303

 Score = 67.0 bits (162), Expect = 1e-11,   Method: Compositional matrix adjust.
 Identities = 67/267 (25%), Positives = 125/267 (46%), Gaps = 52/267 (19%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK--KIKREIKILENL------R 89
           D++ +  LG+G + +V +A N  ++    +K ++  ++K   I  E+ +L +L      R
Sbjct: 7   DFEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRHTEEKLSTILSEVMLLASLNHQYVVR 66

Query: 90  GGPNIITLADIVKDPVS--RTPALVFEHVNNTDFKQLYQTLTDYDI--------RFYMYE 139
                +   + VK P++  +  + +F  +   + + LY  +   ++        R +  +
Sbjct: 67  YYAAWLERRNFVK-PMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQRDEYWRLFR-Q 124

Query: 140 ILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH-------------PGQ 186
           IL+AL Y HS GI+HR++KP N+ ID E R +++ D+GLA+  H             PG 
Sbjct: 125 ILEALSYIHSQGIIHRNLKPMNIFID-ESRNVKIGDFGLAKNVHRSLDILKLDSQNLPGS 183

Query: 187 EYNVR--VASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVR 244
             N+   + +  +   E+L     Y+  +DM+SLG +   MI+   PF  G +  + L +
Sbjct: 184 SDNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMIY---PFSTGMERVNILKK 240

Query: 245 IAKVLGTEDLYDYIDKYNIELDPRFND 271
           +  V             +IE  P F+D
Sbjct: 241 LRSV-------------SIEFPPDFDD 254


>3M42-A nrPDB
          Length = 299

 Score = 67.0 bits (162), Expect = 1e-11,   Method: Compositional matrix adjust.
 Identities = 55/210 (26%), Positives = 97/210 (46%), Gaps = 34/210 (16%)

Query: 37  DDYQLVRK-LGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNII 95
           DDY++  + LG G   +V +  N    EK  +K+L+   K +  RE+++       P+I+
Sbjct: 17  DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKAR--REVELHWRASQCPHIV 74

Query: 96  TLADIVKDPVSRTPAL--VFEHVNNTD-FKQLY----QTLTDYDIRFYMYEILKALDYCH 148
            + D+ ++  +    L  V E ++  + F ++     Q  T+ +    M  I +A+ Y H
Sbjct: 75  RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 134

Query: 149 SMGIMHRDVKPHNVMIDHE--HRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDY 206
           S+ I HRDVKP N++   +  +  L+L D+G A+                          
Sbjct: 135 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKE----------------------TTG 172

Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGH 236
           + YD S DMWSLG ++  ++    PF+  H
Sbjct: 173 EKYDKSCDMWSLGVIMYILLCGYPPFYSNH 202


>4NFN-A nrPDB
          Length = 309

 Score = 67.0 bits (162), Expect = 1e-11,   Method: Compositional matrix adjust.
 Identities = 39/153 (25%), Positives = 81/153 (52%), Gaps = 6/153 (3%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKI-KREIKILENLRGGPNI 94
           +D +++++K+G G + E++EA+++   E V +K+    + K++ K E+ +L+ L+G  ++
Sbjct: 20  KDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDHV 79

Query: 95  ITLADIVKDPVSRTPALVFEHVNNTDFK--QLYQTLTDYDIRFYMYEILKALDYCHSMGI 152
                  ++       +  +  N  D +  Q   T T         +IL++++  HS+G 
Sbjct: 80  CRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHSVGF 139

Query: 153 MHRDVKPHNVMIDH---EHRKLRLIDWGLAEFY 182
           +HRD+KP N  +      +RK  ++D+GLA  Y
Sbjct: 140 LHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQY 172


>4BTK-A nrPDB
          Length = 337

 Score = 67.0 bits (162), Expect = 1e-11,   Method: Compositional matrix adjust.
 Identities = 39/153 (25%), Positives = 81/153 (52%), Gaps = 6/153 (3%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKI-KREIKILENLRGGPNI 94
           +D +++++K+G G + E++EA+++   E V +K+    + K++ K E+ +L+ L+G  ++
Sbjct: 55  KDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDHV 114

Query: 95  ITLADIVKDPVSRTPALVFEHVNNTDFK--QLYQTLTDYDIRFYMYEILKALDYCHSMGI 152
                  ++       +  +  N  D +  Q   T T         +IL++++  HS+G 
Sbjct: 115 CRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHSVGF 174

Query: 153 MHRDVKPHNVMIDH---EHRKLRLIDWGLAEFY 182
           +HRD+KP N  +      +RK  ++D+GLA  Y
Sbjct: 175 LHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQY 207


>4WUA-A nrPDB
          Length = 401

 Score = 66.6 bits (161), Expect = 2e-11,   Method: Compositional matrix adjust.
 Identities = 93/383 (24%), Positives = 160/383 (41%), Gaps = 83/383 (21%)

Query: 20  PREYWDYESHVVEWGN--QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK--K 75
           P +Y     H+V+ G+     Y ++RKLG G +S V+ + +I   + V +K++K  +   
Sbjct: 22  PNDYCKGGYHLVKIGDLFNGRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYT 81

Query: 76  KKIKREIKILENLRGG----PN---IITLADIVK-DPVSRT-PALVFE----HVNNTDFK 122
           +    EI++L+++R      PN   ++ L D  K   V+ T   +VFE    H+     K
Sbjct: 82  ETALDEIRLLKSVRNSDPNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIK 141

Query: 123 QLYQTLTDYDIRFYMYEILKALDYCHSMG-IMHRDVKPHNVMI----------------- 164
             YQ L    ++  + ++L+ LDY H+   I+H D+KP N+++                 
Sbjct: 142 SNYQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEW 201

Query: 165 -------------------------------DHEHRKLRLIDWGLAEFYHPGQEYNVRVA 193
                                          + E  K+++ D G A + H  + +   + 
Sbjct: 202 QRSGAPPPSGSAVSTAPATAGNFLVNPLEPKNAEKLKVKIADLGNACWVH--KHFTEDIQ 259

Query: 194 SRYFKGPELLVDYQMYDYSLDMWSLGCM---LASMIFRKEPFFHGHDNY----DQLVRIA 246
           +R ++  E+L+    Y+   D+WS  CM   LA+  +  EP  H  + Y    D +  I 
Sbjct: 260 TRQYRSLEVLIG-SGYNTPADIWSTACMAFELATGDYLFEP--HSGEEYTRDEDHIALII 316

Query: 247 KVLGTEDLYDYI-DKYNIELDPRFNDILGRHSRKRWERF-VHSENQHLVSPEA---LDFL 301
           ++LG       +  KY+ E   +  D+      K W  F V  E       EA    DFL
Sbjct: 317 ELLGKVPRKLIVAGKYSKEFFTKKGDLKHITKLKPWGLFEVLVEKYEWSQEEAAGFTDFL 376

Query: 302 DKLLRYDHQSRLTAREAMEHPYF 324
             +L    + R TA E + HP+ 
Sbjct: 377 LPMLELIPEKRATAAECLRHPWL 399


>3IS5-A nrPDB
          Length = 285

 Score = 66.2 bits (160), Expect = 2e-11,   Method: Compositional matrix adjust.
 Identities = 65/305 (21%), Positives = 132/305 (43%), Gaps = 54/305 (17%)

Query: 34  GNQDD-YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP----VKKKKIKREIKILENL 88
           G  DD +   RKLG G + +V      ++  + V+K +      V  ++I+ EI++L++L
Sbjct: 18  GTIDDLFIFKRKLGSGAFGDVHLVEERSSGLERVIKTINKDRSQVPMEQIEAEIEVLKSL 77

Query: 89  RGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY-------QTLTDYDIRFYMYEIL 141
              PNII + ++ +D       +V E     +  +         + L++  +   M +++
Sbjct: 78  -DHPNIIKIFEVFED--YHNMYIVMETCEGGELLERIVSAQARGKALSEGYVAELMKQMM 134

Query: 142 KALDYCHSMGIMHRDVKPHNVMIDHE--HRKLRLIDWGLAEFYHPGQEYNVRVASRYFKG 199
            AL Y HS  ++H+D+KP N++      H  +++ID+GLAE +   +       +  +  
Sbjct: 135 NALAYFHSQHVVHKDLKPENILFQDTSPHSPIKIIDFGLAELFKSDEHSTNAAGTALYMA 194

Query: 200 PELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYID 259
           PE+    +   +  D+WS G ++  ++    PF         L  + +    ++      
Sbjct: 195 PEVF--KRDVTFKCDIWSAGVVMYFLLTGCLPF-----TGTSLEEVQQKATYKE-----P 242

Query: 260 KYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAM 319
            Y +E  P                         ++P+A+D L ++L  D + R +A + +
Sbjct: 243 NYAVECRP-------------------------LTPQAVDLLKQMLTKDPERRPSAAQVL 277

Query: 320 EHPYF 324
            H +F
Sbjct: 278 HHEWF 282


>3PFQ-A nrPDB
          Length = 674

 Score = 66.2 bits (160), Expect = 3e-11,   Method: Compositional matrix adjust.
 Identities = 65/225 (28%), Positives = 102/225 (45%), Gaps = 19/225 (8%)

Query: 34  GNQD-----DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP-VKKKKIKREIKILEN 87
           GN+D     D+  +  LG+G + +V  +     +E   VKILK  V  +    E  ++E 
Sbjct: 333 GNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEK 392

Query: 88  ----LRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYD---IRFYMYEI 140
               L G P  +T        + R    V E+VN  D     Q +  +      FY  EI
Sbjct: 393 RVLALPGKPPFLTQLHSCFQTMDRL-YFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEI 451

Query: 141 LKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKG 199
              L +  S GI++RD+K  NVM+D E   +++ D+G+  E    G        +  +  
Sbjct: 452 AIGLFFLQSKGIIYRDLKLDNVMLDSEGH-IKIADFGMCKENIWDGVTTKTFCGTPDYIA 510

Query: 200 PELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVR 244
           PE++  YQ Y  S+D W+ G +L  M+  + P F G D  D+L +
Sbjct: 511 PEIIA-YQPYGKSVDWWAFGVLLYEMLAGQAP-FEGEDE-DELFQ 552


>4U41-A nrPDB
          Length = 332

 Score = 65.9 bits (159), Expect = 3e-11,   Method: Compositional matrix adjust.
 Identities = 56/214 (26%), Positives = 98/214 (45%), Gaps = 17/214 (7%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK--IKREIKILENLRGGPNIIT 96
           ++LV  +G G Y +V++  ++   +   +K++   + ++  IK EI +L+      NI T
Sbjct: 26  FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKKYSHHRNIAT 85

Query: 97  L--ADIVKDPVSRTPAL--VFEHVNNTDFKQLYQ-----TLTDYDIRFYMYEILKALDYC 147
              A I K P      L  V E         L +     TL +  I +   EIL+ L + 
Sbjct: 86  YYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAHL 145

Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGL-AEFYHPGQEYNVRVASRYFKGPELLVDY 206
           H   ++HRD+K  NV++  E+ +++L+D+G+ A+        N  + + Y+  PE++   
Sbjct: 146 HIHHVIHRDIKGQNVLLT-ENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACD 204

Query: 207 Q----MYDYSLDMWSLGCMLASMIFRKEPFFHGH 236
           +     YDY  D+WS G     M     P    H
Sbjct: 205 ENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMH 238


>2I0E-A nrPDB
          Length = 353

 Score = 65.9 bits (159), Expect = 3e-11,   Method: Compositional matrix adjust.
 Identities = 65/225 (28%), Positives = 102/225 (45%), Gaps = 19/225 (8%)

Query: 34  GNQD-----DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP-VKKKKIKREIKILEN 87
           GN+D     D+  +  LG+G + +V  +     +E   VKILK  V  +    E  ++E 
Sbjct: 12  GNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEK 71

Query: 88  ----LRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYD---IRFYMYEI 140
               L G P  +T        + R    V E+VN  D     Q +  +      FY  EI
Sbjct: 72  RVLALPGKPPFLTQLHSCFQTMDRL-YFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEI 130

Query: 141 LKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKG 199
              L +  S GI++RD+K  NVM+D E   +++ D+G+  E    G        +  +  
Sbjct: 131 AIGLFFLQSKGIIYRDLKLDNVMLDSEGH-IKIADFGMCKENIWDGVTTKTFCGTPDYIA 189

Query: 200 PELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVR 244
           PE++  YQ Y  S+D W+ G +L  M+  + P F G D  D+L +
Sbjct: 190 PEIIA-YQPYGKSVDWWAFGVLLYEMLAGQAP-FEGEDE-DELFQ 231


>5KCV-A nrPDB
          Length = 460

 Score = 65.5 bits (158), Expect = 4e-11,   Method: Compositional matrix adjust.
 Identities = 80/308 (25%), Positives = 132/308 (42%), Gaps = 59/308 (19%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP---VKKKKIKR---EIKILENLRG 90
           ++++ ++ LG+G + +V             +KILK    V K ++     E ++L+N R 
Sbjct: 162 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 221

Query: 91  GPNIITLADIVKDPVSRTPALVFEHVNNTD-FKQLYQ--TLTDYDIRFYMYEILKALDYC 147
            P +  L    +         V E+ N  + F  L +    ++   RFY  EI+ ALDY 
Sbjct: 222 -PFLTALKYSFQ--THDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYL 278

Query: 148 HS-MGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLVD 205
           HS   +++RD+K  N+M+D +   +++ D+GL  E    G        +  +  PE+L D
Sbjct: 279 HSEKNVVYRDLKLENLMLDKDGH-IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLED 337

Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIEL 265
              Y  ++D W LG ++  M+  + PF+    N D           E L++ I    I  
Sbjct: 338 ND-YGRAVDWWGLGVVMYEMMCGRLPFY----NQDH----------EKLFELILMEEI-- 380

Query: 266 DPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT-----AREAME 320
             RF   LG                    PEA   L  LL+ D + RL      A+E M+
Sbjct: 381 --RFPRTLG--------------------PEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQ 418

Query: 321 HPYFYTVV 328
           H +F  +V
Sbjct: 419 HRFFAGIV 426


>2UV2-A nrPDB
          Length = 325

 Score = 65.1 bits (157), Expect = 5e-11,   Method: Compositional matrix adjust.
 Identities = 76/308 (24%), Positives = 134/308 (43%), Gaps = 47/308 (15%)

Query: 26  YESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKR---EI 82
           YE    +   +D ++++ +LG G + +V++A N   +     K++    +++++    EI
Sbjct: 26  YEHVTRDLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEI 85

Query: 83  KILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTD--FKQLYQTLTDYDIRFYMYEI 140
            IL +    PNI+ L D      +    + F      D    +L + LT+  I+    + 
Sbjct: 86  DILASC-DHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQT 144

Query: 141 LKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGL-AEFYHPGQEYNVRVASRYFKG 199
           L AL+Y H   I+HRD+K  N++   +   ++L D+G+ A+     Q  +  + + Y+  
Sbjct: 145 LDALNYLHDNKIIHRDLKAGNILFTLDG-DIKLADFGVSAKNTRTIQRRDSFIGTPYWMA 203

Query: 200 PELLVDYQM----YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLY 255
           PE+++        YDY  D+WSLG  L  M    EP  H  +    L++IAK        
Sbjct: 204 PEVVMCETSKDRPYDYKADVWSLGITLIEMA-EIEPPHHELNPMRVLLKIAKS------- 255

Query: 256 DYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTA 315
                     +P     L + S  RW            S    DFL K L  +  +R T 
Sbjct: 256 ----------EPP---TLAQPS--RW------------SSNFKDFLKKCLEKNVDARWTT 288

Query: 316 REAMEHPY 323
            + ++HP+
Sbjct: 289 SQLLQHPF 296


>5FET-A nrPDB
          Length = 847

 Score = 65.1 bits (157), Expect = 5e-11,   Method: Compositional matrix adjust.
 Identities = 45/138 (32%), Positives = 79/138 (57%), Gaps = 8/138 (5%)

Query: 134 RFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVA 193
           +FY+  I+ A++Y H   I++RD+KP N+++D +   ++LID+G A+    G+ Y + V 
Sbjct: 636 QFYLGSIILAIEYLHERNIVYRDLKPENILLDKQGY-VKLIDFGCAKKIQ-GRAYTL-VG 692

Query: 194 SRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVL-GTE 252
           + ++  PE+++  + Y  ++D+W+LG  L   I    PF  G+D  DQL     +L G  
Sbjct: 693 TPHYMAPEVILG-KGYGCTVDIWALGVCLYEFICGPLPF--GNDQEDQLEIFRDILTGQL 749

Query: 253 DLYDYI-DKYNIELDPRF 269
              DY+ D+ +I L  R 
Sbjct: 750 TFPDYVSDQDSINLMKRL 767


>3C51-A nrPDB
          Length = 543

 Score = 65.1 bits (157), Expect = 6e-11,   Method: Compositional matrix adjust.
 Identities = 59/212 (27%), Positives = 89/212 (41%), Gaps = 42/212 (19%)

Query: 135 FYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVAS 194
           FY  +I+  L++ H   I++RD+KP NV++D +   +R+ D GLA     GQ      A 
Sbjct: 293 FYTAQIVSGLEHLHQRNIIYRDLKPENVLLDDDG-NVRISDLGLAVELKAGQTKTKGYAG 351

Query: 195 R-YFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTED 253
              F  PELL+  + YD+S+D ++LG  L  MI  + PF    +  +      +VL  E 
Sbjct: 352 TPGFMAPELLLG-EEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKQRVL--EQ 408

Query: 254 LYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRL 313
              Y DK+                                SP + DF + LL+ D + RL
Sbjct: 409 AVTYPDKF--------------------------------SPASKDFCEALLQKDPEKRL 436

Query: 314 TAREAM-----EHPYFYTVVKDQARMGSSSMP 340
             R+        HP F  +   Q   G  + P
Sbjct: 437 GFRDGSCDGLRTHPLFRDISWRQLEAGMLTPP 468


>5DYK-A nrPDB
          Length = 853

 Score = 64.7 bits (156), Expect = 6e-11,   Method: Compositional matrix adjust.
 Identities = 38/115 (33%), Positives = 69/115 (60%), Gaps = 6/115 (5%)

Query: 128 LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE 187
           L+    +FY+  I+ A++Y H   I++RD+KP N+++D +   ++LID+G A+    G+ 
Sbjct: 636 LSKSQAQFYLGSIILAIEYLHERNIVYRDLKPENILLDKQGY-VKLIDFGCAKKVQ-GRA 693

Query: 188 YNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQL 242
           Y + V + ++  PE+++  + Y  ++D+W+LG  L   I    PF  G+D  DQL
Sbjct: 694 YTL-VGTPHYMAPEVILG-KGYGCTVDIWALGICLYEFICGPLPF--GNDEEDQL 744


>3MV5-A nrPDB
          Length = 342

 Score = 64.7 bits (156), Expect = 6e-11,   Method: Compositional matrix adjust.
 Identities = 76/309 (24%), Positives = 133/309 (43%), Gaps = 61/309 (19%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP---VKKKKIKR---EIKILENLRG 90
           ++++ ++ LG+G + +V             +KILK    V K ++     E ++L+N R 
Sbjct: 10  NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 69

Query: 91  GPNIITLADIVKDPVSRTPALVFEHVNNTD-FKQLYQ--TLTDYDIRFYMYEILKALDYC 147
            P +  L    +         V E+ N  + F  L +    ++   RFY  EI+ ALDY 
Sbjct: 70  -PFLTALKYSFQ--THDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYL 126

Query: 148 HS-MGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLVD 205
           HS   +++RD+K  N+M+D +   +++ D+GL  E    G        +  +  PE+L D
Sbjct: 127 HSEKNVVYRDLKLENLMLDKDGH-IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLED 185

Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFH-GHDNYDQLVRIAKVLGTEDLYDYIDKYNIE 264
              Y  ++D W LG ++  M+  + PF++  H+   +L+ + ++                
Sbjct: 186 ND-YGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEI---------------- 228

Query: 265 LDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRL-----TAREAM 319
              RF   LG                    PEA   L  LL+ D + RL      A+E M
Sbjct: 229 ---RFPRTLG--------------------PEAKSLLSGLLKKDPKQRLGGGSEDAKEIM 265

Query: 320 EHPYFYTVV 328
           +H +F  +V
Sbjct: 266 QHRFFAGIV 274


>3COM-A nrPDB
          Length = 314

 Score = 64.7 bits (156), Expect = 7e-11,   Method: Compositional matrix adjust.
 Identities = 52/205 (25%), Positives = 98/205 (47%), Gaps = 13/205 (6%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK--KKIKREIKILENLRGGPNIIT 96
           + ++ KLG G Y  V++AI+    + V +K + PV+   ++I +EI I++       +  
Sbjct: 31  FDVLEKLGEGSYGSVYKAIHKETGQIVAIKQV-PVESDLQEIIKEISIMQQCDSPHVVKY 89

Query: 97  LADIVKDPVSRTPALVFEHVNNTDFKQLY----QTLTDYDIRFYMYEILKALDYCHSMGI 152
                K+       +V E+        +     +TLT+ +I   +   LK L+Y H M  
Sbjct: 90  YGSYFKN---TDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRK 146

Query: 153 MHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLVDYQMYDY 211
           +HRD+K  N++++ E    +L D+G+A +      + N  + + ++  PE++ +   Y+ 
Sbjct: 147 IHRDIKAGNILLNTEGHA-KLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIG-YNC 204

Query: 212 SLDMWSLGCMLASMIFRKEPFFHGH 236
             D+WSLG     M   K P+   H
Sbjct: 205 VADIWSLGITAIEMAEGKPPYADIH 229


>6CCF-A nrPDB
          Length = 290

 Score = 64.3 bits (155), Expect = 8e-11,   Method: Compositional matrix adjust.
 Identities = 57/254 (22%), Positives = 112/254 (44%), Gaps = 45/254 (17%)

Query: 76  KKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY--QTLTDYDI 133
           +++ +EI IL+ L    N++ L +++ DP      LVF+ +      ++   +  ++   
Sbjct: 73  ERVYQEIAILKKL-DHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEVPCDKPFSEEQA 131

Query: 134 RFYMYEILKALDYCHSMGIMHRDVKPHNVMI-DHEHRKLRLIDWGLA-EFYHPGQEYNVR 191
           R Y+ +++  L+Y H   I+HRD+KP N+++ D  H  +++ D+G++ +F     + +  
Sbjct: 132 RLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGH--VKIADFGVSNQFEGNDAQLSST 189

Query: 192 VASRYFKGPELLVD--YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVL 249
             +  F  PE + D        +LD+W+ G  L   ++ K PF                 
Sbjct: 190 AGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPF----------------- 232

Query: 250 GTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDH 309
                   ID +          IL  H + + E  V  E    +S E  D + K+L  + 
Sbjct: 233 --------IDDF----------ILALHRKIKNEPVVFPEEPE-ISEELKDLILKMLDKNP 273

Query: 310 QSRLTAREAMEHPY 323
           ++R+   +   HP+
Sbjct: 274 ETRIGVPDIKLHPW 287


>6DBN-A nrPDB
          Length = 316

 Score = 64.3 bits (155), Expect = 9e-11,   Method: Compositional matrix adjust.
 Identities = 55/201 (27%), Positives = 97/201 (48%), Gaps = 19/201 (9%)

Query: 42  VRKLGRGKYSEV----FEAINITNNEKVVVKILKPVKKKK----IKREIKILENLRGGPN 93
           +R LG G + +V    ++       E+V VK LKP         +K+EI+IL NL    N
Sbjct: 40  IRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYH-EN 98

Query: 94  IITLADIVKDPVSRTPALVFEHVNNTDFKQ-LYQTLTDYDIR---FYMYEILKALDYCHS 149
           I+    I  +       L+ E + +   K+ L +     +++    Y  +I K +DY  S
Sbjct: 99  IVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGS 158

Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEY----NVRVASRYFKGPELLVD 205
              +HRD+   NV+++ EH+ +++ D+GL +     +EY    + R +  ++  PE L+ 
Sbjct: 159 RQYVHRDLAARNVLVESEHQ-VKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQ 217

Query: 206 YQMYDYSLDMWSLGCMLASMI 226
            + Y  S D+WS G  L  ++
Sbjct: 218 SKFYIAS-DVWSFGVTLHELL 237


>5N23-A nrPDB
          Length = 352

 Score = 64.3 bits (155), Expect = 9e-11,   Method: Compositional matrix adjust.
 Identities = 54/216 (25%), Positives = 104/216 (48%), Gaps = 13/216 (6%)

Query: 26  YESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL---KPVKKKKIKREI 82
           +ES      + D ++ +R LG G +  V    +        +KIL   K VK K+I+  +
Sbjct: 31  WESPAQNTAHLDQFERIRTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTL 90

Query: 83  --KILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTD-FKQLYQT--LTDYDIRFYM 137
             K ++     P ++ L    KD  +    +V E+    + F  L +    ++   RFY 
Sbjct: 91  NEKRIQQAVNFPFLVKLEFSFKD--NSNLYMVLEYAPGGEMFSHLRRIGRFSEPHARFYA 148

Query: 138 YEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYF 197
            +I+   +Y HS+ +++RD+KP N++ID +   +++ D+G A+       + +     Y 
Sbjct: 149 AQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY-IKVADFGFAKRVKGRTPWTLCGTPEYL 207

Query: 198 KGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFF 233
             PE+++  + Y+ ++D W+LG ++  M     PFF
Sbjct: 208 -APEIILS-KGYNKAVDWWALGVLIYEMAAGYPPFF 241


>4RA4-A nrPDB
          Length = 355

 Score = 63.9 bits (154), Expect = 1e-10,   Method: Compositional matrix adjust.
 Identities = 58/204 (28%), Positives = 90/204 (44%), Gaps = 12/204 (5%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP-VKKKKIKREIKILEN----LRGGP 92
           D+  +  LG+G + +V  A      E   +KILK  V  +    E  ++E     L   P
Sbjct: 21  DFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKP 80

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDY---DIRFYMYEILKALDYCHS 149
             +T        V R    V E+VN  D     Q +  +      FY  EI   L + H 
Sbjct: 81  PFLTQLHSCFQTVDRL-YFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHK 139

Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLVDYQM 208
            GI++RD+K  NVM+D E   +++ D+G+  E    G        +  +  PE++  YQ 
Sbjct: 140 RGIIYRDLKLDNVMLDSEGH-IKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIA-YQP 197

Query: 209 YDYSLDMWSLGCMLASMIFRKEPF 232
           Y  S+D W+ G +L  M+  + PF
Sbjct: 198 YGKSVDWWAYGVLLYEMLAGQPPF 221


>4AW2-A nrPDB
          Length = 437

 Score = 63.9 bits (154), Expect = 1e-10,   Method: Compositional matrix adjust.
 Identities = 56/215 (26%), Positives = 101/215 (46%), Gaps = 22/215 (10%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVV-------KILKPVKKKKIKREIKILENL 88
           ++D+++++ +GRG + EV   + + N +KV         ++LK  +    + E  +L N 
Sbjct: 73  REDFEILKVIGRGAFGEV-AVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVN- 130

Query: 89  RGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDY----DIRFYMYEILKAL 144
                I TL    +D       LV ++    D   L     D       RFY+ E++ A+
Sbjct: 131 GDSKWITTLHYAFQD--DNNLYLVMDYYVGGDLLTLLSKFEDRLPEEMARFYLAEMVIAI 188

Query: 145 DYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWG-LAEFYHPGQ-EYNVRVASRYFKGPEL 202
           D  H +  +HRD+KP N+++D  +  +RL D+G   +    G  + +V V +  +  PE+
Sbjct: 189 DSVHQLHYVHRDIKPDNILMDM-NGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEI 247

Query: 203 LVDYQ----MYDYSLDMWSLGCMLASMIFRKEPFF 233
           L   +     Y    D WSLG  +  M++ + PF+
Sbjct: 248 LQAMEGGKGRYGPECDWWSLGVCMYEMLYGETPFY 282


>4IAN-A nrPDB
          Length = 358

 Score = 63.9 bits (154), Expect = 1e-10,   Method: Compositional matrix adjust.
 Identities = 33/114 (28%), Positives = 64/114 (56%), Gaps = 4/114 (3%)

Query: 133 IRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRV 192
           +R Y  ++  AL       I+H D+KP N++++     L+L D+G A  +    +    +
Sbjct: 137 VRSYSQQLFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSAS-HVADNDITPYL 195

Query: 193 ASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIA 246
            SR+++ PE+++  + YDY +DMWS+GC L  + +  +  F G  N + ++++A
Sbjct: 196 VSRFYRAPEIIIG-KSYDYGIDMWSVGCTLYEL-YTGKILFPGKTN-NHMLKLA 246


>6E2O-A nrPDB
          Length = 295

 Score = 63.9 bits (154), Expect = 1e-10,   Method: Compositional matrix adjust.
 Identities = 59/231 (25%), Positives = 108/231 (46%), Gaps = 21/231 (9%)

Query: 19  RPREYWDYESHVVEWGNQDDYQLVRK-LGRGKYSEVFEAINITNNEKVVVKILKPVKKKK 77
           R  E  D ES ++E+  + D    R  LG+G Y  V+   +++N  ++ +K + P +  +
Sbjct: 3   RSTEEGDCESDLLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEI-PERDSR 61

Query: 78  ----IKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----LT 129
               +  EI + ++L+    +  L    ++   +   +  E V       L ++    L 
Sbjct: 62  YSQPLHEEIALHKHLKHKNIVQYLGSFSENGFIK---IFMEQVPGGSLSALLRSKWGPLK 118

Query: 130 DYD--IRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE---FYHP 184
           D +  I FY  +IL+ L Y H   I+HRD+K  NV+I+     L++ D+G ++     +P
Sbjct: 119 DNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINP 178

Query: 185 GQEYNVRVASRYFKGPELL-VDYQMYDYSLDMWSLGCMLASMIFRKEPFFH 234
             E      +  +  PE++    + Y  + D+WSLGC +  M   K PF+ 
Sbjct: 179 CTE--TFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYE 227


>4WB7-A nrPDB
          Length = 405

 Score = 63.5 bits (153), Expect = 1e-10,   Method: Compositional matrix adjust.
 Identities = 57/217 (26%), Positives = 109/217 (50%), Gaps = 16/217 (7%)

Query: 26  YESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL---KPVKKKKIK--- 79
           +ES      + D ++ ++ LG G +  V    +        +KIL   K VK K+I+   
Sbjct: 85  WESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTL 144

Query: 80  REIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTD-FKQLYQT--LTDYDIRFY 136
            E +IL+ +   P ++ L    KD  +    +V E+V   + F  L +    ++   RFY
Sbjct: 145 NEKRILQAV-NFPFLVKLEFSFKD--NSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFY 201

Query: 137 MYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY 196
             +I+   +Y HS+ +++RD+KP N++ID +   +++ D+G A+    G+ + +     Y
Sbjct: 202 AAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY-IQVTDFGFAKRVK-GRTWTLCGTPEY 259

Query: 197 FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFF 233
              PE+++  + Y+ ++D W+LG ++  M     PFF
Sbjct: 260 L-APEIILS-KGYNKAVDWWALGVLIYEMAAGYPPFF 294


>5FQD-C nrPDB
          Length = 341

 Score = 63.5 bits (153), Expect = 1e-10,   Method: Compositional matrix adjust.
 Identities = 47/149 (31%), Positives = 78/149 (52%), Gaps = 6/149 (4%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKI-LKPVKKKKIKREIKILENLRGGPNI--I 95
           Y+LVRK+G G + +++ AINITN E+V VK+  +  +  ++  E K+ + L+GG  I  I
Sbjct: 21  YKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIPHI 80

Query: 96  TLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHR 155
                 KD       L+   + +  F    +  T   +     +++  ++Y H+   +HR
Sbjct: 81  RWYGQEKDYNVLVMDLLGPSLEDL-FNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHR 139

Query: 156 DVKPHNVM--IDHEHRKLRLIDWGLAEFY 182
           D+KP N +  I     KL LID+GLA+ Y
Sbjct: 140 DIKPDNFLMGIGRHCNKLFLIDFGLAKKY 168


>4X3F-A nrPDB
          Length = 337

 Score = 63.5 bits (153), Expect = 1e-10,   Method: Compositional matrix adjust.
 Identities = 52/208 (25%), Positives = 97/208 (46%), Gaps = 17/208 (8%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILK------PVKKKKIKREIKILENLRGGP 92
           Y+L R +  G   +V+EA++     +V VK+LK      P   ++ + E +    L   P
Sbjct: 14  YRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNH-P 72

Query: 93  NIITLADIVKDPV---SRTPALVFEHVNNTDFKQLYQTLTDYDIRF---YMYEILKALDY 146
            I ++ D  +  +    RT  LV E VN      + +      +R     + +  +AL  
Sbjct: 73  GIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQI 132

Query: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFY--HPGQEYNVRVASRYFKGPELLV 204
            H+ G++HRDVKP N++I     ++++ D+G+A+     P  +  + + +  +  PE  +
Sbjct: 133 AHAAGLVHRDVKPGNILITPTG-QVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQAL 191

Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPF 232
            +     S D++SLG +    +  K PF
Sbjct: 192 GHDASPAS-DVYSLGVVGYEAVSGKRPF 218


>5TQX-A nrPDB
          Length = 655

 Score = 63.2 bits (152), Expect = 2e-10,   Method: Compositional matrix adjust.
 Identities = 52/218 (23%), Positives = 99/218 (45%), Gaps = 17/218 (7%)

Query: 32  EWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKI----LKPVKKKKIKREIKILEN 87
           E+G    +++  +LG G +  V    +   + K+ +K     L    +++   EI+I++ 
Sbjct: 3   EFGAGGPWEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCHEIQIMKK 62

Query: 88  LRGGPNIITLADIVKDP---VSRTPALVFEHVNNTDFKQLYQT------LTDYDIRFYMY 138
           L    N++   D+ ++    +   P L  E+ +  D ++L         L +  I   + 
Sbjct: 63  LNHA-NVVKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLS 121

Query: 139 EILKALDYCHSMGIMHRDVKPHNVMIDHEHRKL--RLIDWGLAEFYHPGQEYNVRVASRY 196
           +I   + Y H   I+HRD+KP N+++     K+  ++ID G A+    G+     V +  
Sbjct: 122 DIGSGIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGELCTEFVGTLQ 181

Query: 197 FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFH 234
           +  PEL  + + Y  ++D WS G M+   I    PF H
Sbjct: 182 YLAPELF-ENKPYTATVDYWSFGTMVFECIAGYRPFLH 218


>5X3F-B nrPDB
          Length = 393

 Score = 63.2 bits (152), Expect = 2e-10,   Method: Compositional matrix adjust.
 Identities = 55/206 (26%), Positives = 105/206 (50%), Gaps = 16/206 (7%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL---KPVKKKKIK---REIKILENLRG 90
           D +  ++ LG G +  V    +  +     +KIL   K VK K+I+    E +IL+ +  
Sbjct: 84  DQFDRIKTLGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAV-N 142

Query: 91  GPNIITLADIVKDPVSRTPALVFEHVNNTD-FKQLYQT--LTDYDIRFYMYEILKALDYC 147
            P ++ L    KD  +    +V E+V   + F  L +    ++   RFY  +I+   +Y 
Sbjct: 143 FPFLVKLEFSFKD--NSNLYMVMEYVAGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYL 200

Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQ 207
           HS+ +++RD+KP N++ID +   +++ D+G A+    G+ + +     Y   PE+++  +
Sbjct: 201 HSLDLIYRDLKPENLLIDQQGY-IQVTDFGFAKRVK-GRTWTLCGTPEYL-APEIILS-K 256

Query: 208 MYDYSLDMWSLGCMLASMIFRKEPFF 233
            Y+ ++D W+LG ++  M     PFF
Sbjct: 257 GYNKAVDWWALGVLIYEMAAGYPPFF 282


>2WTK-C nrPDB
          Length = 305

 Score = 62.8 bits (151), Expect = 2e-10,   Method: Compositional matrix adjust.
 Identities = 72/298 (24%), Positives = 124/298 (41%), Gaps = 61/298 (20%)

Query: 45  LGRGKYSEVFEAINITNNEKVVVKILK-------PVKKKKIKREIKILENLRGGPNIITL 97
           LG G Y +V E ++     +  VKILK       P  +  +K+EI++L  LR   N+I L
Sbjct: 13  LGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRH-KNVIQL 71

Query: 98  ADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRF-------YMYEILKALDYCHSM 150
            D++ +   +   +V E+      +++  ++ +   RF       Y  +++  L+Y HS 
Sbjct: 72  VDVLYNEEKQKMYMVMEYCV-CGMQEMLDSVPEK--RFPVCQAHGYFCQLIDGLEYLHSQ 128

Query: 151 GIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHP-GQEYNVRVA--SRYFKGPELLVDYQ 207
           GI+H+D+KP N+++      L++   G+AE  HP   +   R +  S  F+ PE+     
Sbjct: 129 GIVHKDIKPGNLLLT-TGGTLKISALGVAEALHPFAADDTCRTSQGSPAFQPPEIANGLD 187

Query: 208 MYD-YSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 266
            +  + +D+WS G  L ++     P F G + Y     I K             Y I  D
Sbjct: 188 TFSGFKVDIWSAGVTLYNITTGLYP-FEGDNIYKLFENIGK-----------GSYAIPGD 235

Query: 267 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324
                                       P   D L  +L Y+   R + R+  +H +F
Sbjct: 236 --------------------------CGPPLSDLLKGMLEYEPAKRFSIRQIRQHSWF 267


>4OW8-A nrPDB
          Length = 283

 Score = 62.8 bits (151), Expect = 3e-10,   Method: Compositional matrix adjust.
 Identities = 52/208 (25%), Positives = 98/208 (47%), Gaps = 17/208 (8%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILK------PVKKKKIKREIKILENLRGGP 92
           Y+L R +  G   +V+EA++     +V VK+LK      P   ++ + E +    L   P
Sbjct: 13  YRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNH-P 71

Query: 93  NIITLADIVKDPVS---RTPALVFEHVNNTDFKQLYQTLTDYDIRF---YMYEILKALDY 146
            I ++ D  +  ++   RT  LV E VN      + +      +R     + +  +AL  
Sbjct: 72  GIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQI 131

Query: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFY--HPGQEYNVRVASRYFKGPELLV 204
            H+ G++HRDVKP N++I     ++++ D+G+A+     P  +  + + +  +  PE  +
Sbjct: 132 AHAAGLVHRDVKPGNILITPTG-QVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQAL 190

Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPF 232
            +     S D++SLG +    +  K PF
Sbjct: 191 GHDASPAS-DVYSLGVVGYEAVSGKRPF 217


>2XIK-A nrPDB
          Length = 294

 Score = 62.8 bits (151), Expect = 3e-10,   Method: Compositional matrix adjust.
 Identities = 61/218 (27%), Positives = 104/218 (47%), Gaps = 20/218 (9%)

Query: 28  SHVVEWGNQ----DDYQLVRKL---GRGKYSEVFEAINITNNEKVVVKIL----KPVKKK 76
           +H+  + NQ    D  +L  KL   G+G + EV++ I+    E V +KI+       + +
Sbjct: 3   AHLRGFANQHSRVDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIE 62

Query: 77  KIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT--LTDYDIR 134
            I++EI +L               +K   S    ++ E++       L +   L +  I 
Sbjct: 63  DIQQEITVLSQCDSPYITRYFGSYLK---STKLWIIMEYLGGGSALDLLKPGPLEETYIA 119

Query: 135 FYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ-EYNVRVA 193
             + EILK LDY HS   +HRD+K  NV++  E   ++L D+G+A      Q + N  V 
Sbjct: 120 TILREILKGLDYLHSERKIHRDIKAANVLLS-EQGDVKLADFGVAGQLTDTQIKRNTFVG 178

Query: 194 SRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEP 231
           + ++  PE ++    YD+  D+WSLG + A  + + EP
Sbjct: 179 TPFWMAPE-VIKQSAYDFKADIWSLG-ITAIELAKGEP 214


>6B2Q-A nrPDB
          Length = 317

 Score = 62.4 bits (150), Expect = 3e-10,   Method: Compositional matrix adjust.
 Identities = 52/208 (25%), Positives = 98/208 (47%), Gaps = 17/208 (8%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILK------PVKKKKIKREIKILENLRGGP 92
           Y+L R +  G   +V+EA++     +V VK+LK      P   ++ + E +    L   P
Sbjct: 34  YRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNH-P 92

Query: 93  NIITLADIVKDPVS---RTPALVFEHVNNTDFKQLYQTLTDYDIRF---YMYEILKALDY 146
            I ++ D  +  ++   RT  LV E VN      + +      +R     + +  +AL  
Sbjct: 93  GIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQI 152

Query: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFY--HPGQEYNVRVASRYFKGPELLV 204
            H+ G++HRDVKP N++I     ++++ D+G+A+     P  +  + + +  +  PE  +
Sbjct: 153 AHAAGLVHRDVKPGNILITPTG-QVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQAL 211

Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPF 232
            +     S D++SLG +    +  K PF
Sbjct: 212 GHDASPAS-DVYSLGVVGYEAVSGKRPF 238


>4E20-A nrPDB
          Length = 290

 Score = 62.4 bits (150), Expect = 3e-10,   Method: Compositional matrix adjust.
 Identities = 55/216 (25%), Positives = 101/216 (46%), Gaps = 17/216 (7%)

Query: 42  VRKLGRGKYSEV----FEAINITNNEKVVVKILK----PVKKKKIKREIKILENLRGGPN 93
           +R LG G + +V    ++  N    E V VK LK    P  +   +REI+IL  L    +
Sbjct: 13  IRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSGWQREIEILRTLYH-EH 71

Query: 94  IITLADIVKDPVSRTPALVFEHVNNTDFKQLY--QTLTDYDIRFYMYEILKALDYCHSMG 151
           I+      +D   ++  LV E+V     +       +    +  +  +I + + Y H+  
Sbjct: 72  IVKYKGCCEDQGEKSVQLVMEYVPLGSLRDYLPRHCVGLAQLLLFAQQICEGMAYLHAQH 131

Query: 152 IMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE-YNVRV---ASRYFKGPELLVDYQ 207
            +HR +   NV++D++ R +++ D+GLA+    G E Y VR    +  ++  PE L + +
Sbjct: 132 YIHRALAARNVLLDND-RLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKECK 190

Query: 208 MYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLV 243
            Y Y+ D+WS G  L  ++   +     H  + +L+
Sbjct: 191 FY-YASDVWSFGVTLYELLTYCDSNQSPHTKFTELI 225


>2PMN-X nrPDB
          Length = 348

 Score = 62.4 bits (150), Expect = 3e-10,   Method: Compositional matrix adjust.
 Identities = 77/328 (23%), Positives = 144/328 (43%), Gaps = 72/328 (21%)

Query: 37  DDYQLVRKLGRGKYSEV--------FEAI--------------NITNNEKVVVKILKPVK 74
           +DY+++R L +GK++++        F A+                +NN+K+ +K     K
Sbjct: 31  NDYRIIRTLNQGKFNKIILCEKDNKFYALKKYEKSLLEKKRDFTKSNNDKISIK----SK 86

Query: 75  KKKIKREIKILENLRG-----GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLT 129
               K E++I+ +++         IIT  D V         +++E++ N    +  +   
Sbjct: 87  YDDFKNELQIITDIKNEYCLTCEGIITNYDEV--------YIIYEYMENDSILKFDEYFF 138

Query: 130 DYD-----------IRFYMYEILKALDYCHS-MGIMHRDVKPHNVMIDHEHRKLRLIDWG 177
             D           I+  +  +L +  Y H+   I HRDVKP N+++D   R ++L D+G
Sbjct: 139 VLDKNYTCFIPIQVIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMDKNGR-VKLSDFG 197

Query: 178 LAEFYHPGQEYNVRVASRYFKGPELLVDYQMYD-YSLDMWSLGCMLASMIFRKEPFFHGH 236
            +E Y   ++      +  F  PE   +   Y+   +D+WSLG  L  M +   PF    
Sbjct: 198 ESE-YMVDKKIKGSRGTYEFMPPEFFSNESSYNGAKVDIWSLGICLYVMFYNVVPF---- 252

Query: 237 DNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPE 296
                 ++I+ V    +L++ I   NIE     N  L   + K+      + + + +S E
Sbjct: 253 -----SLKISLV----ELFNNIRTKNIEYPLDRNHFLYPLTNKK-----STCSNNFLSNE 298

Query: 297 ALDFLDKLLRYDHQSRLTAREAMEHPYF 324
            +DFL   LR +   R+T+ +A++H + 
Sbjct: 299 DIDFLKLFLRKNPAERITSEDALKHEWL 326


>4C59-A nrPDB
          Length = 340

 Score = 62.0 bits (149), Expect = 4e-10,   Method: Compositional matrix adjust.
 Identities = 61/247 (24%), Positives = 114/247 (46%), Gaps = 35/247 (14%)

Query: 21  REYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL---KPVKKKK 77
           R+  D+    VE G +   ++ R L  G ++ V+EA ++ +  +  +K L   +  K + 
Sbjct: 12  RDQSDFVGQTVELG-ELRLRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRA 70

Query: 78  IKREIKILENLRGGPNII---TLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIR 134
           I +E+  ++ L G PNI+   + A I K+  S T    F  +      QL + L   + R
Sbjct: 71  IIQEVCFMKKLSGHPNIVQFCSAASIGKEE-SDTGQAEFLLLTELCKGQLVEFLKKMESR 129

Query: 135 F---------YMYEILKALDYCHSMG--IMHRDVKPHNVMIDHEHRKLRLIDWGLAEF-- 181
                       Y+  +A+ + H     I+HRD+K  N+++ ++   ++L D+G A    
Sbjct: 130 GPLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQG-TIKLCDFGSATTIS 188

Query: 182 YHPG-----------QEYNVRVASRYFKGPELLVDYQMYDYS--LDMWSLGCMLASMIFR 228
           ++P            +E   R  +  ++ PE++  Y  +      D+W+LGC+L  + FR
Sbjct: 189 HYPDYSWSAQRRALVEEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFR 248

Query: 229 KEPFFHG 235
           + PF  G
Sbjct: 249 QHPFEDG 255


>3VN9-A nrPDB
          Length = 340

 Score = 62.0 bits (149), Expect = 4e-10,   Method: Compositional matrix adjust.
 Identities = 70/342 (20%), Positives = 143/342 (41%), Gaps = 64/342 (18%)

Query: 5   VPSRARVYTDVNTHRPREYWDYESH-VVEWGNQ------DDYQLVRKLGRGKYSEVFEAI 57
           +P  A      ++  PR   D +S   +  GNQ      DD + + +LGRG Y  V +  
Sbjct: 15  IPKEAFEQPQTSSTPPR---DLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMR 71

Query: 58  NITNNEKVVVKILKPV----KKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVF 113
           ++ + + + VK ++      ++K++  ++ I       P  +T    +          + 
Sbjct: 72  HVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGAL---FREGDVWIC 128

Query: 114 EHVNNTDFKQLY-------QTLTDYDIRFYMYEILKALDYCHS-MGIMHRDVKPHNVMID 165
             + +T   + Y       QT+ +  +      I+KAL++ HS + ++HRDVKP NV+I 
Sbjct: 129 MELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLI- 187

Query: 166 HEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELL---VDYQMYDYSLDMWSLGCML 222
           +   ++++ D+G++ +        +    + +  PE +   ++ + Y    D+WSLG  +
Sbjct: 188 NALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITM 247

Query: 223 ASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWE 282
             +   + P+      + QL ++ +                E  P+             +
Sbjct: 248 IELAILRFPYDSWGTPFQQLKQVVE----------------EPSPQLP----------AD 281

Query: 283 RFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324
           +F         S E +DF  + L+ + + R T  E M+HP+F
Sbjct: 282 KF---------SAEFVDFTSQCLKKNSKERPTYPELMQHPFF 314


>2X7G-A nrPDB
          Length = 389

 Score = 62.0 bits (149), Expect = 4e-10,   Method: Compositional matrix adjust.
 Identities = 88/387 (22%), Positives = 157/387 (40%), Gaps = 81/387 (20%)

Query: 14  DVNTHRPREYWDYESHVVEWGN--QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK 71
           D     P +Y     H V+ G+     Y ++RKLG G +S V+   ++     V +K++K
Sbjct: 6   DEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVK 65

Query: 72  PVK--KKKIKREIKILENLR----GGPNIITLADIVKD-PVSRTP----ALVFE----HV 116
             +   +    EIK+L+ +R      PN   +  ++ D  +S        +VFE    H+
Sbjct: 66  SAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHL 125

Query: 117 NNTDFKQLYQTLTDYDIRFYMYEILKALDYCHS-MGIMHRDVKPHNVMI----------- 164
                K  YQ L    ++  + ++L+ LDY HS   I+H D+KP N+++           
Sbjct: 126 LKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMA 185

Query: 165 -----------------------------------DHEHRKLRLIDWGLAEFYHPGQEYN 189
                                              + +  ++++ D G A + H  + + 
Sbjct: 186 AEATEWQKAGAPPPSGSAVSTAPAADLLVNPLDPRNADKIRVKIADLGNACWVH--KHFT 243

Query: 190 VRVASRYFKGPELLVDYQMYDYSLDMWSLGCM---LASMIFRKEPFFHGHDNY----DQL 242
             + +R ++  E+L+    Y    D+WS  CM   LA+  +  EP  H  ++Y    D +
Sbjct: 244 EDIQTRQYRSIEVLIGAG-YSTPADIWSTACMAFELATGDYLFEP--HSGEDYSRDEDHI 300

Query: 243 VRIAKVLGT-EDLYDYIDKYNIELDPRFNDILGRHSRKRWERF-VHSEN---QHLVSPEA 297
             I ++LG+    +    KY+ E   R  ++      K W  F V  E     H  + + 
Sbjct: 301 AHIIELLGSIPRHFALSGKYSREFFNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQF 360

Query: 298 LDFLDKLLRYDHQSRLTAREAMEHPYF 324
            DFL  +L    + R +A E + HP+ 
Sbjct: 361 TDFLIPMLEMVPEKRASAGECLRHPWL 387


>3OMV-A nrPDB
          Length = 307

 Score = 62.0 bits (149), Expect = 5e-10,   Method: Compositional matrix adjust.
 Identities = 59/251 (23%), Positives = 117/251 (46%), Gaps = 43/251 (17%)

Query: 16  NTHRPRE------YWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKI 69
           N  RPR       YW+ E+         +  L  ++G G +  V++      +  V VKI
Sbjct: 17  NKIRPRGQRDSSYYWEIEA--------SEVMLSTRIGSGSFGTVYKG---KWHGDVAVKI 65

Query: 70  LK-----PVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQL 124
           LK     P + +  + E+ +L   R    ++ +  + KD +    A+V +    +    L
Sbjct: 66  LKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNL----AIVTQWCEGSS---L 118

Query: 125 YQTLTDYDIRFYMYEIL-------KALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWG 177
           Y+ L   + +F M++++       + +DY H+  I+HRD+K +N+ + HE   +++ D+G
Sbjct: 119 YKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFL-HEGLTVKIGDFG 177

Query: 178 LAEF---YHPGQEYNVRVASRYFKGPEL--LVDYQMYDYSLDMWSLGCMLASMIFRKEPF 232
           LA     +   Q+      S  +  PE+  + D   + +  D++S G +L  ++  + P+
Sbjct: 178 LATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPY 237

Query: 233 FHGHDNYDQLV 243
            H  +N DQ++
Sbjct: 238 SH-INNRDQII 247


>5DBX-A nrPDB
          Length = 328

 Score = 62.0 bits (149), Expect = 5e-10,   Method: Compositional matrix adjust.
 Identities = 54/218 (24%), Positives = 98/218 (44%), Gaps = 25/218 (11%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK----KIKREIKILENLRGG 91
           +D Y+L   +G G  + V  A+     E+V +K +   K +    ++ +EI+ +      
Sbjct: 10  RDAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMSQC-SH 68

Query: 92  PNIIT--LADIVKDPVSRTPALVFEH---------VNNTDFKQLYQTLTDYDIRFYMYEI 140
           PN++T   + +VKD +     L+            VN  + K     L +  I   + E+
Sbjct: 69  PNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKN--GVLEEAIIATILKEV 126

Query: 141 LKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKG- 199
           L+ LDY H  G +HRD+K  N+++  E   +++ D+G++ F   G +       + F G 
Sbjct: 127 LEGLDYLHRNGQIHRDLKAGNILLG-EDGSVQIADFGVSAFLATGGDVTRNKVRKDFVGT 185

Query: 200 -----PELLVDYQMYDYSLDMWSLGCMLASMIFRKEPF 232
                PE++   + YD+  DMWS G     +     P+
Sbjct: 186 PCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPY 223


>4LG4-A nrPDB
          Length = 299

 Score = 61.6 bits (148), Expect = 5e-10,   Method: Compositional matrix adjust.
 Identities = 51/208 (24%), Positives = 100/208 (48%), Gaps = 13/208 (6%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK--KKIKREIKILENLRGGPN 93
           ++ + ++ KLG G Y  VF+AI+  + + V +K + PV+   ++I +EI I++       
Sbjct: 10  EEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQV-PVESDLQEIIKEISIMQQCDSPYV 68

Query: 94  IITLADIVKDPVSRTPALVFEHVNNTDFKQLY----QTLTDYDIRFYMYEILKALDYCHS 149
           +       K+       +V E+        +     +TL + +I   +   LK L+Y H 
Sbjct: 69  VKYYGSYFKN---TDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHF 125

Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLVDYQM 208
           M  +HR++K  N++++ E    +L D+G+A +      + N  + + ++  PE++ +   
Sbjct: 126 MRKIHRNIKAGNILLNTEGHA-KLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIG- 183

Query: 209 YDYSLDMWSLGCMLASMIFRKEPFFHGH 236
           Y+   D+WSLG     M   K P+   H
Sbjct: 184 YNCVADIWSLGITSIEMAEGKPPYADIH 211


>2F57-A nrPDB
          Length = 317

 Score = 61.6 bits (148), Expect = 5e-10,   Method: Compositional matrix adjust.
 Identities = 49/198 (24%), Positives = 85/198 (42%), Gaps = 38/198 (19%)

Query: 128 LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGL-AEFYHPGQ 186
           + +  I      +L+AL Y H+ G++HRD+K  ++++  + R ++L D+G  A+      
Sbjct: 138 MNEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGR-IKLSDFGFCAQVSKEVP 196

Query: 187 EYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIA 246
           +    V + Y+  PE++     Y   +D+WSLG M+  MI  + P+F+            
Sbjct: 197 KRKSLVGTPYWMAPEVISRLP-YGTEVDIWSLGIMVIEMIDGEPPYFN------------ 243

Query: 247 KVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLR 306
                E     + +    L PR  D+                  H VS     FLD +L 
Sbjct: 244 -----EPPLQAMRRIRDSLPPRVKDL------------------HKVSSVLRGFLDLMLV 280

Query: 307 YDHQSRLTAREAMEHPYF 324
            +   R TA+E + HP+ 
Sbjct: 281 REPSQRATAQELLGHPFL 298


>5LOH-A nrPDB
          Length = 341

 Score = 61.6 bits (148), Expect = 5e-10,   Method: Compositional matrix adjust.
 Identities = 78/320 (24%), Positives = 136/320 (42%), Gaps = 60/320 (18%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK--KKKIKREIKILEN---LRGG 91
           +++ +V+ + RG + +V+  +     +   VK++K      K +  +++   +   L   
Sbjct: 36  EEFSIVKPISRGAFGKVY--LGQKGGKLYAVKVVKKADMINKNMTHQVQAERDALALSKS 93

Query: 92  PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRF---YMYEILKALDYCH 148
           P I+ L   ++   +    LV E++   D K L      +D      Y+ E+  ALDY H
Sbjct: 94  PFIVHLYYSLQS--ANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALALDYLH 151

Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVR--VASRYFKG------P 200
             GI+HRD+KP N++I +E   ++L D+GL++     ++ N+   + +R F G      P
Sbjct: 152 RHGIIHRDLKPDNMLISNEGH-IKLTDFGLSKVTL-NRDINMMDILTTRTFCGTPDYLAP 209

Query: 201 ELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDK 260
           ELL+  + +  ++D W+LG  L   +    PF   +D   Q V                 
Sbjct: 210 ELLLG-RAHGPAVDWWALGVCLFEFLTGIPPF---NDETPQQV----------------- 248

Query: 261 YNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAME 320
                   F +IL R     W      E +  +S  A   ++ LL  D   R   +E   
Sbjct: 249 --------FQNILKRDI--PW-----PEGEEKLSDNAQSAVEILLTIDDTKRAGMKELKR 293

Query: 321 HPYFYTVVKDQARMGSSSMP 340
           HP F  V  D   +   +MP
Sbjct: 294 HPLFSDV--DWENLQHQTMP 311


>4YHJ-A nrPDB
          Length = 584

 Score = 61.2 bits (147), Expect = 7e-10,   Method: Compositional matrix adjust.
 Identities = 34/98 (34%), Positives = 53/98 (54%), Gaps = 2/98 (2%)

Query: 135 FYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVAS 194
           FY  E+   L+      I++RD+KP N+++D +   +R+ D GLA     GQ    RV +
Sbjct: 291 FYAAELCCGLEDLQRERIVYRDLKPENILLD-DRGHIRISDLGLATEIPEGQRVRGRVGT 349

Query: 195 RYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPF 232
             +  PE+ V+ + Y +S D W LGC++  MI    PF
Sbjct: 350 VGYMAPEV-VNNEKYTFSPDWWGLGCLIYEMIQGHSPF 386


>3TKU-A nrPDB
          Length = 433

 Score = 60.8 bits (146), Expect = 9e-10,   Method: Compositional matrix adjust.
 Identities = 58/217 (26%), Positives = 105/217 (48%), Gaps = 24/217 (11%)

Query: 35  NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVV-------KILKPVKKKKIKREIKILEN 87
           +++D+++++ +GRG + EV   + + N E++         ++LK  +    + E  +L N
Sbjct: 88  HREDFEIIKVIGRGAFGEV-AVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVN 146

Query: 88  LRGGPNIIT-LADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDY---DI-RFYMYEILK 142
             G    IT L    +D       LV ++    D   L     D    D+ RFY+ E++ 
Sbjct: 147 --GDCQWITALHYAFQD--ENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVL 202

Query: 143 ALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWG-LAEFYHPGQ-EYNVRVASRYFKGP 200
           A+D  H +  +HRD+KP NV++D  +  +RL D+G   +    G  + +V V +  +  P
Sbjct: 203 AIDSIHQLHYVHRDIKPDNVLLD-VNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISP 261

Query: 201 ELLVDYQ----MYDYSLDMWSLGCMLASMIFRKEPFF 233
           E+L   +     Y    D WSLG  +  M++ + PF+
Sbjct: 262 EILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFY 298


>4FR4-A nrPDB
          Length = 384

 Score = 60.8 bits (146), Expect = 9e-10,   Method: Compositional matrix adjust.
 Identities = 47/211 (22%), Positives = 102/211 (48%), Gaps = 19/211 (9%)

Query: 35  NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKR--------EIKILE 86
           N D ++++R +G+G + +V   I   N+ K +  +    K+K ++R        E++I++
Sbjct: 13  NFDHFEILRAIGKGSFGKV--CIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQ 70

Query: 87  NLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKA 143
            L   P ++ L    +D       +V + +   D +   Q      +  ++ ++ E++ A
Sbjct: 71  GLEH-PFLVNLWYSFQD--EEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELVMA 127

Query: 144 LDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELL 203
           LDY  +  I+HRD+KP N+++D EH  + + D+ +A       +      ++ +  PE+ 
Sbjct: 128 LDYLQNQRIIHRDMKPDNILLD-EHGHVHITDFNIAAMLPRETQITTMAGTKPYMAPEMF 186

Query: 204 VDYQ--MYDYSLDMWSLGCMLASMIFRKEPF 232
              +   Y +++D WSLG     ++  + P+
Sbjct: 187 SSRKGAGYSFAVDWWSLGVTAYELLRGRRPY 217


>6AO5-A nrPDB
          Length = 362

 Score = 60.5 bits (145), Expect = 1e-09,   Method: Compositional matrix adjust.
 Identities = 51/205 (24%), Positives = 98/205 (47%), Gaps = 13/205 (6%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK--KKIKREIKILENLRGGPNIIT 96
           + ++ KLG G Y  VF+AI+  + + V +K + PV+   ++I +EI I++       +  
Sbjct: 12  FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQV-PVESDLQEIIKEISIMQQCDSPYVVKY 70

Query: 97  LADIVKDPVSRTPALVFEHVNNTDFKQLY----QTLTDYDIRFYMYEILKALDYCHSMGI 152
                K+       +V E+        +     +TL + +I   +   LK L+Y H M  
Sbjct: 71  YGSYFKN---TDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRK 127

Query: 153 MHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLVDYQMYDY 211
           +HR++K  N++++ E    +L D+G+A +      + N  + + ++  PE++ +   Y+ 
Sbjct: 128 IHRNIKAGNILLNTEGHA-KLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIG-YNC 185

Query: 212 SLDMWSLGCMLASMIFRKEPFFHGH 236
             D+WSLG     M   K P+   H
Sbjct: 186 VADIWSLGITSIEMAEGKPPYADIH 210


>4FZF-B nrPDB
          Length = 283

 Score = 60.5 bits (145), Expect = 1e-09,   Method: Compositional matrix adjust.
 Identities = 51/200 (25%), Positives = 94/200 (47%), Gaps = 13/200 (6%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKIL----KPVKKKKIKREIKILENLRGGPNI 94
           +  + ++G+G + EVF+ I+    + V +KI+       + + I++EI +L         
Sbjct: 10  FTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSSYVT 69

Query: 95  ITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT--LTDYDIRFYMYEILKALDYCHSMGI 152
                 +K        ++ E++       L +     ++ I   + EILK LDY HS   
Sbjct: 70  KYYGSYLK---GSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSEKK 126

Query: 153 MHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ-EYNVRVASRYFKGPELLVDYQMYDY 211
           +HRD+K  NV++  E   ++L  +G+A      Q + N  V + ++  PE ++    YD 
Sbjct: 127 IHRDIKAANVLL-SEQGDVKLAAFGVAGQLTDTQIKRNTFVGTPFWMAPE-VIQQSAYDS 184

Query: 212 SLDMWSLGCMLASMIFRKEP 231
             D+WSLG + A  + + EP
Sbjct: 185 KADIWSLG-ITAIELAKGEP 203


>2DQ7-X nrPDB
          Length = 283

 Score = 60.5 bits (145), Expect = 1e-09,   Method: Compositional matrix adjust.
 Identities = 46/222 (20%), Positives = 102/222 (45%), Gaps = 18/222 (8%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP--VKKKKIKREIKILENLRGGPN 93
           ++  QL+++LG G++ EV+       N KV +K LKP  +  +    E +I++ L+    
Sbjct: 8   RESLQLIKRLGNGQFGEVWMG-TWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKL 66

Query: 94  IITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRF-----YMYEILKALDYCH 148
           +   A + ++P+     +V E++N        +      ++         ++   + Y  
Sbjct: 67  VQLYAVVSEEPIY----IVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIE 122

Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLVD 205
            M  +HRD++  N+++ +     ++ D+GLA       EY  R  +++   +  PE  + 
Sbjct: 123 RMNYIHRDLRSANILVGN-GLICKIADFGLARLIE-DNEYTARQGAKFPIKWTAPEAAL- 179

Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAK 247
           Y  +    D+WS G +L  ++ +    + G +N + L ++ +
Sbjct: 180 YGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVER 221


>3FME-A nrPDB
          Length = 290

 Score = 59.3 bits (142), Expect = 3e-09,   Method: Compositional matrix adjust.
 Identities = 61/303 (20%), Positives = 130/303 (42%), Gaps = 54/303 (17%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPV----KKKKIKREIKILENLRGGP 92
           DD + + +LGRG Y  V +  ++ + + + VK ++      ++K++  ++ I       P
Sbjct: 7   DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCP 66

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNTDFKQLY-------QTLTDYDIRFYMYEILKALD 145
             +T    +          +   + +T   + Y       QT+ +  +      I+KAL+
Sbjct: 67  FTVTFYGAL---FREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALE 123

Query: 146 YCHS-MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELL- 203
           + HS + ++HRDVKP NV+I +   ++++ D+G++ +       ++    + +  PE + 
Sbjct: 124 HLHSKLSVIHRDVKPSNVLI-NALGQVKMCDFGISGYLVDDVAKDIDAGCKPYMAPERIN 182

Query: 204 --VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKY 261
             ++ + Y    D+WSLG  +  +   + P+      + QL ++ +              
Sbjct: 183 PELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVE-------------- 228

Query: 262 NIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEH 321
             E  P+             ++F         S E +DF  + L+ + + R T  E M+H
Sbjct: 229 --EPSPQLPA----------DKF---------SAEFVDFTSQCLKKNSKERPTYPELMQH 267

Query: 322 PYF 324
           P+F
Sbjct: 268 PFF 270


>4E93-A nrPDB
          Length = 377

 Score = 58.9 bits (141), Expect = 3e-09,   Method: Compositional matrix adjust.
 Identities = 55/201 (27%), Positives = 87/201 (43%), Gaps = 20/201 (9%)

Query: 35  NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVK----ILKPVKKKKIKREIKILENLRG 90
           N +D  L  ++GRG + EVF      +N  V VK     L P  K K  +E +IL+    
Sbjct: 112 NHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQY-S 170

Query: 91  GPNIITLADIV--KDPVSRTPALVFEHVNNTDFKQLYQT----LTDYDIRFYMYEILKAL 144
            PNI+ L  +   K P+     +V E V   DF    +T    L    +   + +    +
Sbjct: 171 HPNIVRLIGVCTQKQPIY----IVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGM 226

Query: 145 DYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPG---QEYNVRVASRYFKGPE 201
           +Y  S   +HRD+   N ++  E   L++ D+G++     G       +R     +  PE
Sbjct: 227 EYLESKCCIHRDLAARNCLVT-EKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPE 285

Query: 202 LLVDYQMYDYSLDMWSLGCML 222
            L +Y  Y    D+WS G +L
Sbjct: 286 AL-NYGRYSSESDVWSFGILL 305


>3ALO-A nrPDB
          Length = 327

 Score = 58.9 bits (141), Expect = 3e-09,   Method: Compositional matrix adjust.
 Identities = 66/318 (20%), Positives = 130/318 (40%), Gaps = 54/318 (16%)

Query: 20  PREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVK-ILKPVKKKKI 78
           P ++WD+ +        +D + + ++GRG Y  V + ++  + + + VK I   V +K+ 
Sbjct: 13  PEQHWDFTA--------EDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQ 64

Query: 79  KREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMY 138
           K+ +  L+ +    +   +              +   + +T F + Y+ +          
Sbjct: 65  KQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPE 124

Query: 139 EIL--------KALDYC-HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYN 189
           EIL        KAL++   ++ I+HRD+KP N+++D     ++L D+G++          
Sbjct: 125 EILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSG-NIKLCDFGISGQLVDSIAKT 183

Query: 190 VRVASRYFKGPELL---VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIA 246
                R +  PE +      Q YD   D+WSLG  L  +   + P+   +  +DQL ++ 
Sbjct: 184 RDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVV 243

Query: 247 KVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLR 306
           K                  DP               +  +SE +   SP  ++F++  L 
Sbjct: 244 KG-----------------DP--------------PQLSNSEEREF-SPSFINFVNLCLT 271

Query: 307 YDHQSRLTAREAMEHPYF 324
            D   R   +E ++HP+ 
Sbjct: 272 KDESKRPKYKELLKHPFI 289


>4M66-A nrPDB
          Length = 325

 Score = 58.9 bits (141), Expect = 3e-09,   Method: Compositional matrix adjust.
 Identities = 48/168 (28%), Positives = 82/168 (48%), Gaps = 13/168 (7%)

Query: 22  EYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKRE 81
           + W   +  V   ++++ + +  +G+G +  VF A + T N  V VKI   V  KKI  E
Sbjct: 5   KLWPTGASAVPLVSREELKKLEFVGKGGFGVVFRAHHRTWNHDVAVKI---VNSKKISWE 61

Query: 82  IKILENLRGGPNIITLADIVKD---PVSRTPALVFEHVNNTDFKQLYQTLTDYD---IRF 135
           +K + NLR   N++ L  + +D         ALV   + N     L Q         +  
Sbjct: 62  VKAMVNLRN-ENVLLLLGVTEDLQWDFVSGQALVTRFMENGSLAGLLQPEAPRPWPLLCR 120

Query: 136 YMYEILKALDYCHSMG--IMHRDVKPHNVMIDHEHRKLRLIDWGLAEF 181
            + E++  + Y HS+   ++HRD+KP N+++D E    +L D+GL+ F
Sbjct: 121 LLQEVVLGMCYLHSLDPPLLHRDLKPSNILLDPELHA-KLADFGLSTF 167


>6HV0-A nrPDB
          Length = 416

 Score = 58.5 bits (140), Expect = 4e-09,   Method: Compositional matrix adjust.
 Identities = 66/286 (23%), Positives = 118/286 (41%), Gaps = 57/286 (19%)

Query: 61  NNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKD------PVSRTPALVFE 114
           +N  V VK + P       RE+++L      PN+I      KD       +    A + E
Sbjct: 31  DNRDVAVKRILPECFSFADREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQE 90

Query: 115 HVNNTDFKQL-YQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMID----HEHR 169
           +V   DF  L  + +T       + +    L + HS+ I+HRD+KPHN++I     H   
Sbjct: 91  YVEQKDFAHLGLEPIT------LLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKI 144

Query: 170 KLRLIDWGLAEFYHPGQEYNVRVA----SRYFKGPELLVD--YQMYDYSLDMWSLGCMLA 223
           K  + D+GL +    G+    R +    +  +  PE+L +   +   Y++D++S GC+  
Sbjct: 145 KAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFY 204

Query: 224 SMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWER 283
            +I         H     L R A +L      D +     E      D++ R        
Sbjct: 205 YVISEG-----SHPFGKSLQRQANILLGACSLDCLHPEKHE------DVIAR-------- 245

Query: 284 FVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 329
                          + ++K++  D Q R +A+  ++HP+F+++ K
Sbjct: 246 ---------------ELIEKMIAMDPQKRPSAKHVLKHPFFWSLEK 276


>4PL5-B nrPDB
          Length = 435

 Score = 58.5 bits (140), Expect = 5e-09,   Method: Compositional matrix adjust.
 Identities = 67/287 (23%), Positives = 126/287 (43%), Gaps = 59/287 (20%)

Query: 61  NNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKD------PVSRTPALVFE 114
           +N  V VK + P       RE+++L      PN+I      KD       +    A + E
Sbjct: 50  DNRDVAVKRILPECFSFADREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQE 109

Query: 115 HVNNTDFKQL-YQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMID----HEHR 169
           +V   DF  L  + +T       +++    L + HS+ I+HRD+KPHN+++     H   
Sbjct: 110 YVEQKDFAHLGLEPIT------LLHQTTSGLAHLHSLNIVHRDLKPHNILLSMPNAHGRI 163

Query: 170 KLRLIDWGLAEFYHPGQEYNVRVA----SRYFKGPELLVDYQMYD--YSLDMWSLGCMLA 223
           K  + D+GL +    G+    R +    +  +  PE+L +    +  Y++D++S GC+  
Sbjct: 164 KAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKDNPTYTVDIFSAGCVFY 223

Query: 224 SMIFRKEPFFHGHDNYDQLVRIAKV-LGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWE 282
            +I   E +   H     L R A + LG  +L    D ++ +   +  D++ R       
Sbjct: 224 YVI--SEGY---HPFGKSLQRQANILLGACNL----DCFHSD---KHEDVIAR------- 264

Query: 283 RFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 329
                           + ++K++  D Q R +A+  ++HP+F+++ K
Sbjct: 265 ----------------ELIEKMIAMDPQQRPSAKHVLKHPFFWSLEK 295


>4CSV-A nrPDB
          Length = 275

 Score = 58.5 bits (140), Expect = 5e-09,   Method: Compositional matrix adjust.
 Identities = 51/220 (23%), Positives = 102/220 (46%), Gaps = 15/220 (6%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK--PVKKKKIKREIKILENLRGGPN 93
           + +  L RKLG G++ EV+E      N +V VK LK   +  ++  +E +I++ L+  PN
Sbjct: 10  RSEITLERKLGSGQFGEVYEGKWRNYNIEVAVKTLKEGTMSVEEFLQEAQIMKKLK-HPN 68

Query: 94  IITLADIV-KDPVSRTPALVFEHVNNTDFKQLYQ--TLTDYDIRFYMYEILKALDYCHSM 150
           ++ L  +  K+P          H +  D+ +  +  T+    +     ++   + Y  S 
Sbjct: 69  LVQLYGVCTKEPPIYIITEYMSHGSLLDYLRDCEGHTVNAQALLDMAAQVASGMAYLESQ 128

Query: 151 GIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLVDYQ 207
             +HRD+   N ++  E+  +++ D+GLA   +   EY  R  +++   +  PE  + Y 
Sbjct: 129 NFIHRDLAARNCLVG-ENNVVKVADFGLARLINE-DEYTARAGAKFPIKWTAPE-AISYN 185

Query: 208 MYDYSLDMWSLGCMLASMIFRKE---PFFHGHDNYDQLVR 244
            +    D+W+ G +L  +    +   P   G +  +Q+ R
Sbjct: 186 RFSIKSDVWAFGILLWEIFTYGQVPYPGMSGSEVIEQVER 225


>2PZI-A nrPDB
          Length = 681

 Score = 58.2 bits (139), Expect = 6e-09,   Method: Compositional matrix adjust.
 Identities = 53/184 (28%), Positives = 89/184 (48%), Gaps = 19/184 (10%)

Query: 92  PNIITLADIVK------DPVSRTPALVFEHVNNTDFKQLY-QTLTDYDIRFYMYEILKAL 144
           P+I+ + + V+      DPV     +V E+V     K+   Q L   +   Y+ EIL AL
Sbjct: 139 PSIVQIFNFVEHTDRHGDPVGY---IVMEYVGGQSLKRSKGQKLPVAEAIAYLLEILPAL 195

Query: 145 DYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLV 204
            Y HS+G+++ D+KP N+M+  E  +L+LID G     +    +     +  F+ PE++ 
Sbjct: 196 SYLHSIGLVYNDLKPENIMLTEE--QLKLIDLGAVSRIN---SFGYLYGTPGFQAPEIV- 249

Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIE 264
                  + D++++G  LA++     P  +G    D L     VL T D Y  + +  I+
Sbjct: 250 -RTGPTVATDIYTVGRTLAALTL-DLPTRNGR-YVDGLPEDDPVLKTYDSYGRLLRRAID 306

Query: 265 LDPR 268
            DPR
Sbjct: 307 PDPR 310


>4HVI-A nrPDB
          Length = 314

 Score = 58.2 bits (139), Expect = 6e-09,   Method: Compositional matrix adjust.
 Identities = 49/196 (25%), Positives = 96/196 (48%), Gaps = 18/196 (9%)

Query: 42  VRKLGRGKYSEV----FEAINITNNEKVVVKILK---PVKKKKIKREIKILENLRGGPNI 94
           + +LG+G +  V    ++ +       V VK L+   P +++  +REI+IL+ L     I
Sbjct: 15  ISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSD-FI 73

Query: 95  ITLADIVKDPVSRTPALVFEHVNNT---DFKQLYQTLTDYD-IRFYMYEILKALDYCHSM 150
           +    +   P  ++  LV E++ +    DF Q ++   D   +  Y  +I K ++Y  S 
Sbjct: 74  VKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSR 133

Query: 151 GIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNV----RVASRYFKGPELLVDY 206
             +HRD+   N++++ E   +++ D+GLA+     ++Y V      +  ++  PE L D 
Sbjct: 134 RCVHRDLAARNILVESEAH-VKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSD- 191

Query: 207 QMYDYSLDMWSLGCML 222
            ++    D+WS G +L
Sbjct: 192 NIFSRQSDVWSFGVVL 207


>4Y12-A nrPDB
          Length = 375

 Score = 58.2 bits (139), Expect = 7e-09,   Method: Compositional matrix adjust.
 Identities = 53/184 (28%), Positives = 89/184 (48%), Gaps = 19/184 (10%)

Query: 92  PNIITLADIVK------DPVSRTPALVFEHVNNTDFKQLY-QTLTDYDIRFYMYEILKAL 144
           P+I+ + + V+      DPV     +V E+V     K+   Q L   +   Y+ EIL AL
Sbjct: 178 PSIVQIFNFVEHTDRHGDPVGY---IVMEYVGGQSLKRSKGQKLPVAEAIAYLLEILPAL 234

Query: 145 DYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLV 204
            Y HS+G+++ D+KP N+M+  E  +L+LID G     +    +     +  F+ PE++ 
Sbjct: 235 SYLHSIGLVYNDLKPENIMLTEE--QLKLIDLGAVSRIN---SFGYLYGTPGFQAPEIVR 289

Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIE 264
                  + D++++G  LA++     P  +G    D L     VL T D Y  + +  I+
Sbjct: 290 TGPT--VATDIYTVGRTLAALTL-DLPTRNGR-YVDGLPEDDPVLKTYDSYGRLLRRAID 345

Query: 265 LDPR 268
            DPR
Sbjct: 346 PDPR 349


>6GVJ-A nrPDB
          Length = 429

 Score = 57.8 bits (138), Expect = 8e-09,   Method: Compositional matrix adjust.
 Identities = 74/314 (23%), Positives = 125/314 (39%), Gaps = 77/314 (24%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKI--------KREIKILENLRG 90
           Y +++++G G  S+VF+ +N    EK  +  +K V  ++         + EI  L  L+ 
Sbjct: 146 YSILKQIGSGGSSKVFQVLN----EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQ 201

Query: 91  -GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ---TLTDYDIRFYMYEILKALDY 146
               II L D   +   +   +V E   N D     +   ++  ++ + Y   +L+A+  
Sbjct: 202 HSDKIIRLYDY--EITDQYIYMVME-CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHT 258

Query: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVR---VASRYFKGPELL 203
            H  GI+H D+KP N +I      L+LID+G+A    P     V+   V +  +  PE +
Sbjct: 259 IHQHGIVHSDLKPANFLI--VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAI 316

Query: 204 VDYQ----------MYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTED 253
            D                  D+WSLGC+L  M + K PF                   + 
Sbjct: 317 KDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF-------------------QQ 357

Query: 254 LYDYIDKYNIELDP----RFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDH 309
           + + I K +  +DP     F DI  +                    +  D L   L+ D 
Sbjct: 358 IINQISKLHAIIDPNHEIEFPDIPEK--------------------DLQDVLKCCLKRDP 397

Query: 310 QSRLTAREAMEHPY 323
           + R++  E + HPY
Sbjct: 398 KQRISIPELLAHPY 411


>5HI2-A nrPDB
          Length = 283

 Score = 57.8 bits (138), Expect = 9e-09,   Method: Compositional matrix adjust.
 Identities = 49/215 (22%), Positives = 101/215 (46%), Gaps = 24/215 (11%)

Query: 43  RKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVK 102
           +++G G +  V++      +  V VK+L P + +  K E+ +L   R   NI+       
Sbjct: 26  QRIGSGSFGTVYKG---KWHGDVAVKMLTPQQLQAFKNEVGVLRKTRH-VNILLFMGYST 81

Query: 103 DPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEIL-------KALDYCHSMGIMHR 155
            P     A+V +    +    LY  L   + +F M +++       + +DY H+  I+HR
Sbjct: 82  KP---QLAIVTQWCEGSS---LYHHLHASETKFEMKKLIDIARQTARGMDYLHAKSIIHR 135

Query: 156 DVKPHNVMIDHEHRKLRLIDWGLAEF---YHPGQEYNVRVASRYFKGPEL--LVDYQMYD 210
           D+K +N+ + HE   +++ D+GLA     +    ++     S  +  PE+  + D   Y 
Sbjct: 136 DLKSNNIFL-HEDNTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDSNPYS 194

Query: 211 YSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRI 245
           +  D+++ G +L  ++  + P +   +N DQ++ +
Sbjct: 195 FQSDVYAFGIVLYELMTGQLP-YSNINNRDQIIEM 228


>5H2U-A nrPDB
          Length = 267

 Score = 57.4 bits (137), Expect = 1e-08,   Method: Compositional matrix adjust.
 Identities = 56/225 (24%), Positives = 109/225 (48%), Gaps = 27/225 (12%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP---VKKKKIKREIKILENLRGGP 92
           ++++ L RKLG G + EVFE +   +  +V +K++     + ++ ++ EI+ ++ LR   
Sbjct: 5   REEFTLCRKLGSGYFGEVFEGL-WKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLR-HK 62

Query: 93  NIITLADIVK--DPVSRTPAL-----VFEHVNNTDFKQL-YQTLTDYDIRFYMYEILKAL 144
           +I+ L  +V   DPV     L     + E + ++D K L    L D       +++ + +
Sbjct: 63  HILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLD-----IAWQVAEGM 117

Query: 145 DYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA----EFYHPGQEYNVRVASRYFKGP 200
            Y  S   +HRD+   N+++  E+   ++ D+GLA    E  +   ++N+      +  P
Sbjct: 118 CYLESQNYIHRDLAARNILVG-ENTLCKVGDFGLARLIKEDVYLSHDHNIPYK---WTAP 173

Query: 201 ELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRI 245
           E L     Y    D+WS G +L  M  R +  + G  N++  +R+
Sbjct: 174 EAL-SRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRV 217


>4APC-A nrPDB
          Length = 350

 Score = 57.4 bits (137), Expect = 1e-08,   Method: Compositional matrix adjust.
 Identities = 46/214 (21%), Positives = 104/214 (48%), Gaps = 16/214 (7%)

Query: 33  WGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVK-----ILKPVKKKKIKREIKILEN 87
           + + + Y  ++K+G G + +     +  +  + V+K      +   ++++ +RE+ +L N
Sbjct: 20  FQSMEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLAN 79

Query: 88  LRGGPNIITLADIVKDPVSRTPALVFEHVNNTD-FKQLYQT----LTDYDIRFYMYEILK 142
           ++  PNI+   +  ++  + +  +V ++    D FK++         +  I  +  +I  
Sbjct: 80  MKH-PNIVQYRESFEE--NGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICL 136

Query: 143 ALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEY-NVRVASRYFKGPE 201
           AL + H   I+HRD+K  N+ +  +   ++L D+G+A   +   E     + + Y+  PE
Sbjct: 137 ALKHVHDRKILHRDIKSQNIFLTKDG-TVQLGDFGIARVLNSTVELARACIGTPYYLSPE 195

Query: 202 LLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHG 235
            + + + Y+   D+W+LGC+L  +   K  F  G
Sbjct: 196 -ICENKPYNNKSDIWALGCVLYELCTLKHAFEAG 228


>5O2B-A nrPDB
          Length = 285

 Score = 57.4 bits (137), Expect = 1e-08,   Method: Compositional matrix adjust.
 Identities = 64/296 (21%), Positives = 125/296 (42%), Gaps = 57/296 (19%)

Query: 44  KLGRGKYSEVFEAINITNNEKVVV-----KILKPVKKKKIKREIKILENLRGGPNIITLA 98
           +LGRG +  V++ ++     +V       + L   ++++ K E ++L+ L+  PNI+   
Sbjct: 23  ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQH-PNIVRFY 81

Query: 99  D----IVKDPVSRTPALVFEHVNNTDFK---QLYQTLTDYDIRFYMYEILKALDYCHSMG 151
           D    I+K    +   LV E + +   K   + ++ +    +R +  +ILK L + H+  
Sbjct: 82  DSWESILKG--KKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRT 139

Query: 152 --IMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMY 209
             I+HRD+K  N+ I      +++ D GLA         +V + +  F  PE+  ++  Y
Sbjct: 140 PPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSV-IGTPEFMAPEMYEEH--Y 196

Query: 210 DYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDP-R 268
           D S+D+++ G  +  M   + P+     N  Q+ R               K    + P  
Sbjct: 197 DESVDVYAFGMCMLEMATSEYPYSECQ-NAAQIYR---------------KVTSGIKPAS 240

Query: 269 FNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324
           FN +                      PE  + ++  +R +   RL+ R+ + H +F
Sbjct: 241 FNKV--------------------TDPEVKEIIEGCIRQNKSERLSIRDLLNHAFF 276


>4IDT-A nrPDB
          Length = 356

 Score = 57.0 bits (136), Expect = 1e-08,   Method: Compositional matrix adjust.
 Identities = 60/228 (26%), Positives = 92/228 (40%), Gaps = 32/228 (14%)

Query: 25  DYE-SHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIK 83
           DYE    V W     +QL  +LGRG + EV    +     +  VK        K++ E+ 
Sbjct: 66  DYEYREEVHWAT---HQL--RLGRGSFGEVHRMEDKQTGFQCAVK--------KVRLEVF 112

Query: 84  ILENLRG-----GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ---TLTDYDIRF 135
             E L        P I+ L   V++       +  E +      QL +    L +    +
Sbjct: 113 RAEELMACAGLTSPRIVPLYGAVRE--GPWVNIFMELLEGGSLGQLVKEQGCLPEDRALY 170

Query: 136 YMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASR 195
           Y+ + L+ L+Y HS  I+H DVK  NV++  +     L D+G A    P       +   
Sbjct: 171 YLGQALEGLEYLHSRRILHGDVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKDLLTGD 230

Query: 196 YFKGPEL-----LVDYQMYDYSLDMWSLGCMLASMIFRKEP---FFHG 235
           Y  G E      +V  +  D  +D+WS  CM+  M+    P   FF G
Sbjct: 231 YIPGTETHMAPEVVLGRSCDAKVDVWSSCCMMLHMLNGCHPWTQFFRG 278


>5O2C-A nrPDB
          Length = 380

 Score = 57.0 bits (136), Expect = 1e-08,   Method: Compositional matrix adjust.
 Identities = 64/296 (21%), Positives = 125/296 (42%), Gaps = 57/296 (19%)

Query: 44  KLGRGKYSEVFEAINITNNEKVVV-----KILKPVKKKKIKREIKILENLRGGPNIITLA 98
           +LGRG +  V++ ++     +V       + L   ++++ K E ++L+ L+  PNI+   
Sbjct: 32  ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQH-PNIVRFY 90

Query: 99  D----IVKDPVSRTPALVFEHVNNTDFK---QLYQTLTDYDIRFYMYEILKALDYCHSMG 151
           D    I+K    +   LV E + +   K   + ++ +    +R +  +ILK L + H+  
Sbjct: 91  DSWESILKG--KKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRT 148

Query: 152 --IMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMY 209
             I+HRD+K  N+ I      +++ D GLA         +V + +  F  PE+  ++  Y
Sbjct: 149 PPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSV-IGTPEFMAPEMYEEH--Y 205

Query: 210 DYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDP-R 268
           D S+D+++ G  +  M   + P+     N  Q+ R               K    + P  
Sbjct: 206 DESVDVYAFGMCMLEMATSEYPYSECQ-NAAQIYR---------------KVTSGIKPAS 249

Query: 269 FNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324
           FN +                      PE  + ++  +R +   RL+ R+ + H +F
Sbjct: 250 FNKV--------------------TDPEVKEIIEGCIRQNKSERLSIRDLLNHAFF 285


>4H1J-A nrPDB
          Length = 293

 Score = 57.0 bits (136), Expect = 2e-08,   Method: Compositional matrix adjust.
 Identities = 50/209 (23%), Positives = 98/209 (46%), Gaps = 14/209 (6%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK-------KKIKREIKILENL 88
           ++D  L R LG G + EV+E +   +  + +   +K  KK       +K   E  I++NL
Sbjct: 23  REDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNL 82

Query: 89  RGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ-TLTDYDIRFYMYEILKALDYC 147
              P+I+ L  I+++  +     ++ +     + +  + +L    +  Y  +I KA+ Y 
Sbjct: 83  -DHPHIVKLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYL 141

Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFK--GPELLVD 205
            S+  +HRD+   N+++      ++L D+GL+ +      Y   V     K   PE  ++
Sbjct: 142 ESINCVHRDIAVRNILVASPE-CVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPE-SIN 199

Query: 206 YQMYDYSLDMWSLG-CMLASMIFRKEPFF 233
           ++ +  + D+W    CM   + F K+PFF
Sbjct: 200 FRRFTTASDVWMFAVCMWEILSFGKQPFF 228


>2VD5-A nrPDB
          Length = 412

 Score = 56.2 bits (134), Expect = 2e-08,   Method: Compositional matrix adjust.
 Identities = 58/218 (26%), Positives = 94/218 (43%), Gaps = 24/218 (11%)

Query: 35  NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKI------LKPVKKKKIKREIKILENL 88
            +DD+++++ +GRG +SEV         +   +KI      LK  +    + E  +L N 
Sbjct: 59  QRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVN- 117

Query: 89  RGGPNIIT-LADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYD----IRFYMYEILKA 143
            G    IT L    +D       LV E+    D   L     +       RFY+ EI+ A
Sbjct: 118 -GDRRWITQLHFAFQD--ENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMA 174

Query: 144 LDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWG-LAEFYHPGQEYN-VRVASRYFKGPE 201
           +D  H +G +HRD+KP N+++D     +RL D+G   +    G   + V V +  +  PE
Sbjct: 175 IDSVHRLGYVHRDIKPDNILLDR-CGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPE 233

Query: 202 LLVDYQMYDY------SLDMWSLGCMLASMIFRKEPFF 233
           +L                D W+LG     M + + PF+
Sbjct: 234 ILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFY 271


>3HMP-A nrPDB
          Length = 342

 Score = 56.2 bits (134), Expect = 2e-08,   Method: Compositional matrix adjust.
 Identities = 58/219 (26%), Positives = 97/219 (44%), Gaps = 34/219 (15%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKI--------KREIKILENLRG 90
           Y +++++G G  S+VF+ +N    EK  +  +K V  ++         + EI  L  L+ 
Sbjct: 58  YSILKQIGSGGSSKVFQVLN----EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQ 113

Query: 91  -GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ---TLTDYDIRFYMYEILKALDY 146
               II L D   +   +   +V E   N D     +   ++  ++ + Y   +L+A+  
Sbjct: 114 HSDKIIRLYDY--EITDQYIYMVME-CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHT 170

Query: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVR---VASRYFKGPELL 203
            H  GI+H D+KP N +I      L+LID+G+A    P     V+   V +  +  PE +
Sbjct: 171 IHQHGIVHSDLKPANFLI--VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAI 228

Query: 204 VDYQ----------MYDYSLDMWSLGCMLASMIFRKEPF 232
            D                  D+WSLGC+L  M + K PF
Sbjct: 229 KDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF 267


>2ZMD-A nrPDB
          Length = 390

 Score = 56.2 bits (134), Expect = 2e-08,   Method: Compositional matrix adjust.
 Identities = 58/219 (26%), Positives = 97/219 (44%), Gaps = 34/219 (15%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKI--------KREIKILENLRG 90
           Y +++++G G  S+VF+ +N    EK  +  +K V  ++         + EI  L  L+ 
Sbjct: 58  YSILKQIGSGGSSKVFQVLN----EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQ 113

Query: 91  -GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ---TLTDYDIRFYMYEILKALDY 146
               II L D   +   +   +V E   N D     +   ++  ++ + Y   +L+A+  
Sbjct: 114 HSDKIIRLYDY--EITDQYIYMVME-CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHT 170

Query: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVR---VASRYFKGPELL 203
            H  GI+H D+KP N +I      L+LID+G+A    P     V+   V +  +  PE +
Sbjct: 171 IHQHGIVHSDLKPANFLI--VDGMLKLIDFGIANQMQPDTTSVVKDSQVGAVNYMPPEAI 228

Query: 204 VDYQ----------MYDYSLDMWSLGCMLASMIFRKEPF 232
            D                  D+WSLGC+L  M + K PF
Sbjct: 229 KDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF 267


>3SV0-A nrPDB
          Length = 483

 Score = 56.2 bits (134), Expect = 2e-08,   Method: Compositional matrix adjust.
 Identities = 42/152 (27%), Positives = 78/152 (51%), Gaps = 8/152 (5%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK--KIKREIKILENLRGGPNI 94
           + ++L RK+G G + E++   NI  NE+V +K L+ VK K  ++  E KI   L+GG  I
Sbjct: 7   NKFRLGRKIGSGSFGEIYLGTNIQTNEEVAIK-LENVKTKHPQLLYESKIYRILQGGTGI 65

Query: 95  --ITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGI 152
             +    +  D       L+   + +  F    + L+   +     +++  +++ HS   
Sbjct: 66  PNVRWFGVEGDYNVLVMDLLGPSLEDL-FNFCSRKLSLKTVLMLADQMINRVEFVHSKSF 124

Query: 153 MHRDVKPHNVMIDHEHR--KLRLIDWGLAEFY 182
           +HRD+KP N ++    R  ++ +ID+GLA+ Y
Sbjct: 125 LHRDIKPDNFLMGLGRRANQVYIIDFGLAKKY 156


>5X5O-A nrPDB
          Length = 310

 Score = 55.8 bits (133), Expect = 3e-08,   Method: Compositional matrix adjust.
 Identities = 53/207 (25%), Positives = 105/207 (50%), Gaps = 25/207 (12%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIIT 96
           DD Q     G G +  V+ A  I+ +++V VK     K  KI++E +IL  L    NII 
Sbjct: 15  DDLQFFENCGGGSFGSVYRAKWISQDKEVAVK-----KLLKIEKEAEILSVL-SHRNIIQ 68

Query: 97  LADIVKDP-----VSRTPAL--VFEHVNNTDFKQLYQTLTDYD-IRFYMYEILKALDYCH 148
              ++ +P     V+   +L  +++++N+   +++     D D I  +  ++ K + Y H
Sbjct: 69  FYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEM-----DMDHIMTWATDVAKGMHYLH 123

Query: 149 S---MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVD 205
               + ++HRD+K  NV+I  +   L++ D+G + F++     ++ V +  +  PE++  
Sbjct: 124 MEAPVKVIHRDLKSRNVVIAADGV-LKICDFGASRFHNHTTHMSL-VGTFPWMAPEVIQS 181

Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPF 232
             + + + D +S G +L  M+ R+ PF
Sbjct: 182 LPVSE-TCDTYSYGVVLWEMLTREVPF 207


>4PWN-A nrPDB
          Length = 274

 Score = 55.8 bits (133), Expect = 3e-08,   Method: Compositional matrix adjust.
 Identities = 47/192 (24%), Positives = 92/192 (47%), Gaps = 16/192 (8%)

Query: 44  KLGRGKYSEVFEAINITNNEKVVV-----KILKPVKKKKIKREIKILENLRGGPNIITLA 98
           ++GRG +  V++ ++     +V       + L   ++++ K E ++L+ L+  PNI+   
Sbjct: 17  EIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQH-PNIVRFY 75

Query: 99  DIVKDPVS--RTPALVFEHVNNTDFK---QLYQTLTDYDIRFYMYEILKALDYCHSMG-- 151
           D  +  V   +   LV E + +   K   + ++ +    +R +  +ILK L + H+    
Sbjct: 76  DSWESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKGLQFLHTRTPP 135

Query: 152 IMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDY 211
           I+HRD+K  N+ I      +++ D GLA            + +  F  PE+    + YD 
Sbjct: 136 IIHRDLKCDNIFITGPTGSVKIGDLGLATLEKRASFAKSVIGTPEFMAPEMY--EEKYDE 193

Query: 212 SLDMWSLG-CML 222
           S+D+++ G CML
Sbjct: 194 SVDVYAFGMCML 205


>4XEY-B nrPDB
          Length = 408

 Score = 55.8 bits (133), Expect = 3e-08,   Method: Compositional matrix adjust.
 Identities = 44/195 (22%), Positives = 92/195 (47%), Gaps = 12/195 (6%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK--PVKKKKIKREIKILENLRGGPN 93
           + D  +  KLG G+Y EV+E +    +  V VK LK   ++ ++  +E  +++ ++  PN
Sbjct: 124 RTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIK-HPN 182

Query: 94  IITLADIV-KDPVSRTPALVFEHVNNTDF-KQLYQTLTDYDIRFYM-YEILKALDYCHSM 150
           ++ L  +  ++P          + N  D+ ++  +   +  +  YM  +I  A++Y    
Sbjct: 183 LVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKK 242

Query: 151 GIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLVDYQ 207
             +HRD+   N ++   H  +++ D+GL+     G  Y     +++   +  PE L  Y 
Sbjct: 243 NFIHRDLAARNCLVGENHL-VKVADFGLSRLM-TGDTYTAHAGAKFPIKWTAPESLA-YN 299

Query: 208 MYDYSLDMWSLGCML 222
            +    D+W+ G +L
Sbjct: 300 KFSIKSDVWAFGVLL 314


>5HIE-A nrPDB
          Length = 302

 Score = 55.8 bits (133), Expect = 3e-08,   Method: Compositional matrix adjust.
 Identities = 49/213 (23%), Positives = 100/213 (46%), Gaps = 24/213 (11%)

Query: 43  RKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVK 102
           +++G G +  V++      +  V VK+L P + +  K E+ +L   R   NI+       
Sbjct: 42  QRIGSGSFGTVYKG---KWHGDVAVKMLTPQQLQAFKNEVGVLRKTRH-VNILLFMGYST 97

Query: 103 DPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEIL-------KALDYCHSMGIMHR 155
            P     A+V +    +    LY  L   + +F M +++       + +DY H+  I+HR
Sbjct: 98  KP---QLAIVTQWCEGSS---LYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHR 151

Query: 156 DVKPHNVMIDHEHRKLRLIDWGLAEF---YHPGQEYNVRVASRYFKGPEL--LVDYQMYD 210
           D+K +N+ + HE   +++ D+GLA     +    ++     S  +  PE+  + D   Y 
Sbjct: 152 DLKSNNIFL-HEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYS 210

Query: 211 YSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLV 243
           +  D+++ G +L  ++  + P +   +N DQ++
Sbjct: 211 FQSDVYAFGIVLYELMTGQLP-YSNINNRDQII 242


>6BXI-A nrPDB
          Length = 333

 Score = 55.5 bits (132), Expect = 4e-08,   Method: Compositional matrix adjust.
 Identities = 60/242 (24%), Positives = 105/242 (43%), Gaps = 52/242 (21%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIIT 96
           +D++ ++ +GRG + EV             +KIL+  K   +++E   + ++R   +I+ 
Sbjct: 6   EDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILR--KADMLEKEQ--VGHIRAERDILV 61

Query: 97  LAD---IVKDPVSRTPAL----VFEHVNNTDFKQLYQ---TLTDYDIRFYMYEILKALDY 146
            AD   +VK   S    L    + E +   D   L     TLT+ + +FY+ E + A+D 
Sbjct: 62  EADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDS 121

Query: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA---------EFYH----------PGQE 187
            H +G +HRD+KP N+++D +   ++L D+GL          EFY             Q 
Sbjct: 122 IHQLGFIHRDIKPDNLLLDSKGH-VKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQN 180

Query: 188 YNVRVASRYFK-----------------GPELLVDYQMYDYSLDMWSLGCMLASMIFRKE 230
            N +  +  +K                  PE+ +    Y+   D WSLG ++  M+    
Sbjct: 181 MNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTG-YNKLCDWWSLGVIMYEMLIGYP 239

Query: 231 PF 232
           PF
Sbjct: 240 PF 241


>5AP3-A nrPDB
          Length = 313

 Score = 55.5 bits (132), Expect = 4e-08,   Method: Compositional matrix adjust.
 Identities = 58/219 (26%), Positives = 98/219 (44%), Gaps = 34/219 (15%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKI--------KREIKILENLRG 90
           Y +++++G G  S+VF+ +N    EK  +  +K V  ++         + EI  L  L+ 
Sbjct: 30  YSILKQIGSGGSSKVFQVLN----EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQ 85

Query: 91  -GPNIITLADIVKDPVSRTPALVFEHVNNTDFK---QLYQTLTDYDIRFYMYEILKALDY 146
               II L D   +   +   +V E   N D     +  +++  ++ + Y   +L+A+  
Sbjct: 86  HSDKIIRLYDY--EITDQYIYMVME-CGNIDLNGWLKKKKSIDPWERKSYWKNMLEAVHT 142

Query: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVR---VASRYFKGPELL 203
            H  GI+H D+KP N +I      L+LID+G+A    P     V+   V +  +  PE +
Sbjct: 143 IHQHGIVHSDLKPANFLI--VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAI 200

Query: 204 VDYQ----------MYDYSLDMWSLGCMLASMIFRKEPF 232
            D                  D+WSLGC+L  M + K PF
Sbjct: 201 KDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF 239


>2H8H-A nrPDB
          Length = 535

 Score = 55.5 bits (132), Expect = 4e-08,   Method: Compositional matrix adjust.
 Identities = 47/222 (21%), Positives = 100/222 (45%), Gaps = 18/222 (8%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP--VKKKKIKREIKILENLRGGPN 93
           ++  +L  KLG+G + EV+         +V +K LKP  +  +   +E ++++ LR    
Sbjct: 266 RESLRLEVKLGQGCFGEVWMG-TWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKL 324

Query: 94  IITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRF-----YMYEILKALDYCH 148
           +   A + ++P+     +V E+++        +  T   +R         +I   + Y  
Sbjct: 325 VQLYAVVSEEPI----YIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVE 380

Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLVD 205
            M  +HRD++  N+++  E+   ++ D+GLA       EY  R  +++   +  PE  + 
Sbjct: 381 RMNYVHRDLRAANILVG-ENLVCKVADFGLARLIE-DNEYTARQGAKFPIKWTAPEAAL- 437

Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAK 247
           Y  +    D+WS G +L  +  +    + G  N + L ++ +
Sbjct: 438 YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER 479


>6F3F-A nrPDB
          Length = 455

 Score = 55.5 bits (132), Expect = 4e-08,   Method: Compositional matrix adjust.
 Identities = 48/222 (21%), Positives = 100/222 (45%), Gaps = 18/222 (8%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP--VKKKKIKREIKILENLRGGPN 93
           ++  +L  KLG+G + EV+         +V +K LKP  +  +   +E ++++ LR    
Sbjct: 186 RESLRLEVKLGQGCFGEVWMG-TWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKL 244

Query: 94  IITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRF-----YMYEILKALDYCH 148
           +   A + ++P+     +V E++N        +  T   +R         +I   + Y  
Sbjct: 245 VQLYAVVSEEPI----YIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVE 300

Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLVD 205
            M  +HRD++  N+++  E+   ++ D+GLA       EY  R  +++   +  PE  + 
Sbjct: 301 RMNYVHRDLRAANILVG-ENLVCKVADFGLARLIE-DNEYTARQGAKFPIKWTAPEAAL- 357

Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAK 247
           Y  +    D+WS G +L  +  +    + G  N + L ++ +
Sbjct: 358 YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER 399


>4G3E-A nrPDB
          Length = 352

 Score = 54.7 bits (130), Expect = 7e-08,   Method: Compositional matrix adjust.
 Identities = 48/202 (23%), Positives = 84/202 (41%), Gaps = 23/202 (11%)

Query: 44  KLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRG-----GPNIITLA 98
           ++GRG + EV    +     +  VK        K++ E+  +E L        P I+ L 
Sbjct: 81  RVGRGSFGEVHRMKDKQTGFQCAVK--------KVRLEVFRVEELVACAGLSSPRIVPLY 132

Query: 99  DIVKDPVSRTPALVFEHVNNTDFKQLYQ---TLTDYDIRFYMYEILKALDYCHSMGIMHR 155
             V++       +  E +      QL +    L +    +Y+ + L+ L+Y H+  I+H 
Sbjct: 133 GAVRE--GPWVNIFMELLEGGSLGQLIKQMGCLPEDRALYYLGQALEGLEYLHTRRILHG 190

Query: 156 DVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPEL-----LVDYQMYD 210
           DVK  NV++  +  +  L D+G A    P       +   Y  G E      +V  +  D
Sbjct: 191 DVKADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAPEVVMGKPCD 250

Query: 211 YSLDMWSLGCMLASMIFRKEPF 232
             +D+WS  CM+  M+    P+
Sbjct: 251 AKVDIWSSCCMMLHMLNGCHPW 272


>2W1I-A nrPDB
          Length = 326

 Score = 54.7 bits (130), Expect = 7e-08,   Method: Compositional matrix adjust.
 Identities = 47/202 (23%), Positives = 104/202 (51%), Gaps = 18/202 (8%)

Query: 40  QLVRKLGRGKYSEV----FEAINITNNEKVVVKILKPVKKKKIK---REIKILENLRGGP 92
           + +++LG+G +  V    ++ +     E V VK L+   ++ ++   REI+IL++L+   
Sbjct: 44  KFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHD- 102

Query: 93  NIITLADIVKDPVSRTPALVFEHV---NNTDFKQLYQTLTDY-DIRFYMYEILKALDYCH 148
           NI+    +      R   L+ E++   +  D+ Q ++   D+  +  Y  +I K ++Y  
Sbjct: 103 NIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLG 162

Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE-YNVRVASR---YFKGPELLV 204
           +   +HRD+   N+++++E+R +++ D+GL +     +E Y V+       ++  PE L 
Sbjct: 163 TKRYIHRDLATRNILVENENR-VKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLT 221

Query: 205 DYQMYDYSLDMWSLGCMLASMI 226
           + + +  + D+WS G +L  + 
Sbjct: 222 ESK-FSVASDVWSFGVVLYELF 242


>3IO7-A nrPDB
          Length = 313

 Score = 54.7 bits (130), Expect = 7e-08,   Method: Compositional matrix adjust.
 Identities = 49/214 (22%), Positives = 108/214 (50%), Gaps = 18/214 (8%)

Query: 28  SHVVEWGNQDDYQLVRKLGRGKYSEV----FEAINITNNEKVVVKILKPVKKKKIK---R 80
           SH +    +   + +++LG+G +  V    ++ +     E V VK L+   ++ ++   R
Sbjct: 19  SHNMTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFER 78

Query: 81  EIKILENLRGGPNIITLADIVKDPVSRTPALVFEHV---NNTDFKQLYQTLTDY-DIRFY 136
           EI+IL++L+   NI+    +      R   L+ E++   +  D+ Q ++   D+  +  Y
Sbjct: 79  EIEILKSLQH-DNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQY 137

Query: 137 MYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE-YNVRVASR 195
             +I K ++Y  +   +HRD+   N+++++E+R +++ D+GL +     +E Y V+    
Sbjct: 138 TSQICKGMEYLGTKRYIHRDLATRNILVENENR-VKIGDFGLTKVLPQDKEYYKVKEPGE 196

Query: 196 ---YFKGPELLVDYQMYDYSLDMWSLGCMLASMI 226
              ++  PE L + + +  + D+WS G +L  + 
Sbjct: 197 SPIFWYAPESLTESK-FSVASDVWSFGVVLYELF 229


>3CJF-A nrPDB
          Length = 309

 Score = 54.7 bits (130), Expect = 7e-08,   Method: Compositional matrix adjust.
 Identities = 54/213 (25%), Positives = 98/213 (46%), Gaps = 28/213 (13%)

Query: 36  QDDYQLVRKLGRGKYSEVFEA----INITNNEKVV-VKILKP----VKKKKIKREIKILE 86
           +D   L + LGRG + +V EA    I+ T   + V VK+LK      + + +  E+KIL 
Sbjct: 26  RDRLNLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILI 85

Query: 87  NLRGGPNIITLADIVKDPVSRTPALV-FEHVNNTD------------FKQLYQT-LTDYD 132
           ++    N++ L      P      +V F    N              +K LY+  LT   
Sbjct: 86  HIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKDLYKDFLTLEH 145

Query: 133 IRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRV 192
           +  Y +++ K +++  S   +HRD+   N+++  E   +++ D+GLA   +   +Y  + 
Sbjct: 146 LICYSFQVAKGMEFLASRKCIHRDLAARNILLS-EKNVVKICDFGLARDIYKDPDYVRKG 204

Query: 193 ASRY---FKGPELLVDYQMYDYSLDMWSLGCML 222
            +R    +  PE + D ++Y    D+WS G +L
Sbjct: 205 DARLPLKWMAPETIFD-RVYTIQSDVWSFGVLL 236


>2FO0-A nrPDB
          Length = 495

 Score = 54.3 bits (129), Expect = 8e-08,   Method: Compositional matrix adjust.
 Identities = 43/195 (22%), Positives = 92/195 (47%), Gaps = 12/195 (6%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK--PVKKKKIKREIKILENLRGGPN 93
           + D  +  KLG G+Y EV+E +    +  V VK LK   ++ ++  +E  +++ ++  PN
Sbjct: 216 RTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIK-HPN 274

Query: 94  IITLADIV-KDPVSRTPALVFEHVNNTDF-KQLYQTLTDYDIRFYM-YEILKALDYCHSM 150
           ++ L  +  ++P          + N  D+ ++  +   +  +  YM  +I  A++Y    
Sbjct: 275 LVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKK 334

Query: 151 GIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLVDYQ 207
             +HR++   N ++   H  +++ D+GL+     G  Y     +++   +  PE L  Y 
Sbjct: 335 NFIHRNLAARNCLVGENHL-VKVADFGLSRLM-TGDTYTAHAGAKFPIKWTAPESLA-YN 391

Query: 208 MYDYSLDMWSLGCML 222
            +    D+W+ G +L
Sbjct: 392 KFSIKSDVWAFGVLL 406


>4LQP-A nrPDB
          Length = 508

 Score = 54.3 bits (129), Expect = 8e-08,   Method: Compositional matrix adjust.
 Identities = 43/163 (26%), Positives = 80/163 (49%), Gaps = 15/163 (9%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVV--KILKPVKKKK-----IKREIKILENLR 89
           +D+  V+ +G+G + EV   +   +  K+     +LK    KK     +K E  +L    
Sbjct: 102 EDFHTVKVIGKGAFGEV-RLVQKKDTGKIYAMKTLLKSEMYKKDQLAHVKAERDVLAG-S 159

Query: 90  GGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQL---YQTLTDYDIRFYMYEILKALDY 146
             P +++L    +D  ++   L+ E +   D   +   +Q  T+   RFYM E + A++ 
Sbjct: 160 DSPWVVSLYYSFQD--AQYLYLIMEFLPGGDLMTMLIRWQLFTEDVTRFYMAECILAIET 217

Query: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYN 189
            H +G +HR +KP N++ID     ++L D+GL+  +H   + N
Sbjct: 218 IHKLGFIHRAIKPDNILIDIRGH-IKLSDFGLSTGFHKTHDSN 259


>2BUJ-A nrPDB
          Length = 317

 Score = 54.3 bits (129), Expect = 9e-08,   Method: Compositional matrix adjust.
 Identities = 58/236 (24%), Positives = 111/236 (47%), Gaps = 27/236 (11%)

Query: 21  REYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL---KPVKKKK 77
           RE   ++ H+V   N+  Y  ++KLG G +S V     + +     +K +   +   +++
Sbjct: 14  RENLYFQGHMVIIDNKH-YLFIQKLGEGGFSYVDLVEGLHDGHFYALKRILCHEQQDREE 72

Query: 78  IKREIKILENLRGGPNIITL-ADIVKDPVSRTPALVF-------EHVNNTD-FKQLYQTL 128
            +RE   +  L   PNI+ L A  +++  ++  A +           N  +  K     L
Sbjct: 73  AQREAD-MHRLFNHPNILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFL 131

Query: 129 TDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWG---LAEFYHPG 185
           T+  I + +  I + L+  H+ G  HRD+KP N+++  E + + L+D G    A  +  G
Sbjct: 132 TEDQILWLLLGICRGLEAIHAKGYAHRDLKPTNILLGDEGQPV-LMDLGSMNQACIHVEG 190

Query: 186 -------QEYNVRVASRYFKGPELLV--DYQMYDYSLDMWSLGCMLASMIFRKEPF 232
                  Q++  +  +  ++ PEL     + + D   D+WSLGC+L +M+F + P+
Sbjct: 191 SRQALTLQDWAAQRCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPY 246


>3BEA-A nrPDB
          Length = 333

 Score = 54.3 bits (129), Expect = 1e-07,   Method: Compositional matrix adjust.
 Identities = 54/214 (25%), Positives = 94/214 (43%), Gaps = 29/214 (13%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNE-----KVVVKILKPV----KKKKIKREIKILE 86
           +++ Q  + LG G + +V EA      +     KV VK+LK      +K+ +  E+KI+ 
Sbjct: 45  RNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMS 104

Query: 87  NLRGGPNIITLAD---------IVKDPVSRTPALVF----EHVNNTD--FKQLYQTLTDY 131
           +L    NI+ L           ++ +       L F      V  TD  F     TL+  
Sbjct: 105 HLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKSRVLETDPAFAIANSTLSTR 164

Query: 132 DIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVR 191
           D+  +  ++ + + +  S   +HRDV   NV++ + H   ++ D+GLA        Y V+
Sbjct: 165 DLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVA-KIGDFGLARDIMNDSNYIVK 223

Query: 192 VASRY---FKGPELLVDYQMYDYSLDMWSLGCML 222
             +R    +  PE + D  +Y    D+WS G +L
Sbjct: 224 GNARLPVKWMAPESIFDC-VYTVQSDVWSYGILL 256


>6NPU-A nrPDB
          Length = 298

 Score = 53.9 bits (128), Expect = 1e-07,   Method: Compositional matrix adjust.
 Identities = 44/193 (22%), Positives = 91/193 (47%), Gaps = 12/193 (6%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK--PVKKKKIKREIKILENLRGGPNII 95
           D  +  KLG G+Y EV+E +    +  V VK LK   ++ ++  +E  +++ ++  PN++
Sbjct: 27  DITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIK-HPNLV 85

Query: 96  TLADIV-KDPVSRTPALVFEHVNNTDF-KQLYQTLTDYDIRFYM-YEILKALDYCHSMGI 152
            L  +  ++P          + N  D+ ++  +   +  +  YM  +I  A++Y      
Sbjct: 86  QLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNF 145

Query: 153 MHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLVDYQMY 209
           +HRD+   N ++   H  +++ D+GL+     G  Y     +++   +  PE L  Y  +
Sbjct: 146 IHRDLAARNCLVGENHL-VKVADFGLSRL-MTGDTYTAHAGAKFPIKWTAPESLA-YNKF 202

Query: 210 DYSLDMWSLGCML 222
               D+W+ G +L
Sbjct: 203 SIKSDVWAFGVLL 215


>5O0Y-A nrPDB
          Length = 579

 Score = 53.9 bits (128), Expect = 1e-07,   Method: Compositional matrix adjust.
 Identities = 70/303 (23%), Positives = 128/303 (42%), Gaps = 62/303 (20%)

Query: 50  YSEVFEAINITNNEKVVVKILKPVKK----------KKIKREIKILENLRGGPNIITLAD 99
           +SEV++A ++T    V VKI +  K           K   RE +I + L   P I+ L D
Sbjct: 297 FSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKEL-DHPRIVKLYD 355

Query: 100 IVK-DPVSRTPALVFEHVNNTDF--KQLYQTLTDYDIRFYMYEILKALDYCHSMG--IMH 154
               D  S    L +   N+ DF  KQ ++ +++ + R  + +I+ AL Y + +   I+H
Sbjct: 356 YFSLDTDSFCTVLEYCEGNDLDFYLKQ-HKLMSEKEARSIIMQIVNALKYLNEIKPPIIH 414

Query: 155 RDVKPHNVMIDH--EHRKLRLIDWGLAEFYH-------PGQEYNVRVASRY-FKGPELLV 204
            D+KP N+++ +     ++++ D+GL++           G E   + A  Y +  PE  V
Sbjct: 415 YDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFV 474

Query: 205 ---DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKY 261
              +       +D+WS+G +    ++ ++PF H     D L     +  TE         
Sbjct: 475 VGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATE--------- 525

Query: 262 NIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEH 321
            ++  P+                       +V+PEA  F+ + L Y  + R+  ++    
Sbjct: 526 -VQFPPK----------------------PVVTPEAKAFIRRCLAYRKEDRIDVQQLACD 562

Query: 322 PYF 324
           PY 
Sbjct: 563 PYL 565


>5KKR-C nrPDB
          Length = 395

 Score = 53.9 bits (128), Expect = 1e-07,   Method: Compositional matrix adjust.
 Identities = 50/208 (24%), Positives = 91/208 (43%), Gaps = 22/208 (10%)

Query: 37  DDYQLVRKLGRGKYSEVFEAI----NITNNEKVVVKILKPVKKKKIKREIKILENLRGGP 92
           DD++ + +LG G    VF+       +    K++   +KP  + +I RE+++L      P
Sbjct: 68  DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNS-P 126

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYCHS 149
            I+              ++  EH++     Q+ +    + +  +      ++K L Y   
Sbjct: 127 YIVGFYGAFYS--DGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLRE 184

Query: 150 M-GIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ----EYNVRVASRYFKGPELLV 204
              IMHRDVKP N++++    +++L D+G++     GQ      N  V +R +  PE L 
Sbjct: 185 KHKIMHRDVKPSNILVN-SRGEIKLCDFGVS-----GQLIDSMANSFVGTRSYMSPERLQ 238

Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPF 232
               Y    D+WS+G  L  M   + P 
Sbjct: 239 GTH-YSVQSDIWSMGLSLVEMAVGRYPI 265


>3EQC-A nrPDB
          Length = 360

 Score = 53.1 bits (126), Expect = 2e-07,   Method: Compositional matrix adjust.
 Identities = 50/208 (24%), Positives = 91/208 (43%), Gaps = 22/208 (10%)

Query: 37  DDYQLVRKLGRGKYSEVFEAI----NITNNEKVVVKILKPVKKKKIKREIKILENLRGGP 92
           DD++ + +LG G    VF+       +    K++   +KP  + +I RE+++L      P
Sbjct: 33  DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNS-P 91

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYCHS 149
            I+              ++  EH++     Q+ +    + +  +      ++K L Y   
Sbjct: 92  YIVGFYGAFYS--DGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLRE 149

Query: 150 M-GIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ----EYNVRVASRYFKGPELLV 204
              IMHRDVKP N++++    +++L D+G++     GQ      N  V +R +  PE L 
Sbjct: 150 KHKIMHRDVKPSNILVN-SRGEIKLCDFGVS-----GQLIDSMANSFVGTRSYMSPERLQ 203

Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPF 232
               Y    D+WS+G  L  M   + P 
Sbjct: 204 GTH-YSVQSDIWSMGLSLVEMAVGRYPI 230


>4AN9-A nrPDB
          Length = 301

 Score = 53.1 bits (126), Expect = 2e-07,   Method: Compositional matrix adjust.
 Identities = 50/207 (24%), Positives = 91/207 (43%), Gaps = 22/207 (10%)

Query: 37  DDYQLVRKLGRGKYSEVFEAI----NITNNEKVVVKILKPVKKKKIKREIKILENLRGGP 92
           DD++ + +LG G    VF+       +    K++   +KP  + +I RE+++L      P
Sbjct: 9   DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNS-P 67

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYCHS 149
            I+              ++  EH++     Q+ +    + +  +      ++K L Y   
Sbjct: 68  YIVGFYGAFYS--DGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLRE 125

Query: 150 M-GIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ----EYNVRVASRYFKGPELLV 204
              IMHRDVKP N++++    +++L D+G++     GQ      N  V +R +  PE L 
Sbjct: 126 KHKIMHRDVKPSNILVN-SRGEIKLCDFGVS-----GQLIDEMANEFVGTRSYMSPERLQ 179

Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEP 231
               Y    D+WS+G  L  M   + P
Sbjct: 180 GTH-YSVQSDIWSMGLSLVEMAVGRYP 205


>6CTH-A nrPDB
          Length = 309

 Score = 53.1 bits (126), Expect = 2e-07,   Method: Compositional matrix adjust.
 Identities = 62/249 (24%), Positives = 111/249 (44%), Gaps = 25/249 (10%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKR---EIKILENLRGGPNI 94
           ++    KLG G +  V+      ++  + VK +    K+ IK    E+KI+  LR   N+
Sbjct: 16  NFNAENKLGEGGFGSVYRGFLRDSDTYIAVKKVSRASKQGIKEYASEVKIISRLRH-KNL 74

Query: 95  ITLADIVKDPVSRTPALVFEHVNNTD-----FKQLYQTLTDYDIRFYMY-EILKALDYCH 148
           + L     +       LV+E + N       FK   ++L  +++R+ +  ++  AL Y H
Sbjct: 75  VKLIGWCHE--RGELMLVYEFMANGSLDSHIFKG--KSLLTWEVRYRIVKDLASALLYLH 130

Query: 149 SMG---IMHRDVKPHNVMIDHEHRKLRLIDWGLAEF--YHPGQEYNVRVASRYFKGPELL 203
             G   ++HRD+K  N+M+D      +L D+GLA    +  G +  +   +  +  PE L
Sbjct: 131 EEGDHCVLHRDIKTSNIMLDSSFNA-KLGDFGLARLVDHAKGLKKTLLAGTVGYMAPECL 189

Query: 204 VDYQMYDYSLDMWSLGCM---LASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYID- 259
              +    S D++S G +   +AS     EP F   +    +  + +  G E + D  D 
Sbjct: 190 SSGKASKES-DVYSFGVVALEIASGRRSIEPKFEESEALLLVPWVWESYGNERILDIADR 248

Query: 260 KYNIELDPR 268
           K  +  DP+
Sbjct: 249 KLGMAFDPK 257


>4M7I-A nrPDB
          Length = 299

 Score = 52.8 bits (125), Expect = 2e-07,   Method: Compositional matrix adjust.
 Identities = 49/223 (21%), Positives = 105/223 (47%), Gaps = 36/223 (16%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK----PVKKKKIKREIKILENLRGGPN 93
           D++ ++ LGRG +  VFEA N  ++    +K ++     + ++K+ RE+K L  L   P 
Sbjct: 6   DFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEH-PG 64

Query: 94  IIT-----LADIVKDPVSRTPALVFEHV--------NNTDFKQLYQTLTDYDIRFYMY-- 138
           I+      L     + +  +   V+ ++        N  D+     T+ + +    ++  
Sbjct: 65  IVRYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIF 124

Query: 139 -EILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE---------- 187
            +I +A+++ HS G+MHRD+KP N+    +   +++ D+GL       +E          
Sbjct: 125 LQIAEAVEFLHSKGLMHRDLKPSNIFFTMDD-VVKVGDFGLVTAMDQDEEEQTVLTPMPA 183

Query: 188 ---YNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIF 227
              +  +V ++ +  PE  +    Y + +D++SLG +L  +++
Sbjct: 184 YARHTGQVGTKLYMSPE-QIHGNSYSHKVDIFSLGLILFELLY 225


>5VD3-A nrPDB
          Length = 311

 Score = 52.8 bits (125), Expect = 2e-07,   Method: Compositional matrix adjust.
 Identities = 51/218 (23%), Positives = 91/218 (41%), Gaps = 20/218 (9%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVK-----ILKPVKKKKIKREIKILENLRG 90
           Q  +Q + +LG G Y EVF+  +  +     VK        P  + +   E+   E +  
Sbjct: 56  QQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQ 115

Query: 91  GPNIITLADIVKDPVSRTPALVF--EHVNNTDFKQLYQ----TLTDYDIRFYMYEILKAL 144
            P  + L    ++       +++    +     +Q  +    +L +  +  Y+ + L AL
Sbjct: 116 HPCCVRLEQAWEEG-----GILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLAL 170

Query: 145 DYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLV 204
            + HS G++H DVKP N+ +    R  +L D+GL           V+     +  PELL 
Sbjct: 171 AHLHSQGLVHLDVKPANIFLGPRGR-CKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQ 229

Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQL 242
               Y  + D++SLG  +  +    E   HG + + QL
Sbjct: 230 GS--YGTAADVFSLGLTILEVACNME-LPHGGEGWQQL 264


>3A4O-X nrPDB
          Length = 286

 Score = 52.4 bits (124), Expect = 3e-07,   Method: Compositional matrix adjust.
 Identities = 50/225 (22%), Positives = 105/225 (46%), Gaps = 23/225 (10%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP--VKKKKIKREIKILENLRGGP- 92
           ++  +LV++LG G++ EV+      N+ KV VK LKP  +  +    E  +++ L+    
Sbjct: 12  RESIKLVKRLGAGQFGEVWMGY-YNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKL 70

Query: 93  ----NIITLAD---IVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALD 145
                ++T  +   I+ + +++   L F   ++   K L   L D+       +I + + 
Sbjct: 71  VRLYAVVTREEPIYIITEYMAKGSLLDFLK-SDEGGKVLLPKLIDFSA-----QIAEGMA 124

Query: 146 YCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPEL 202
           Y      +HRD++  NV++  E    ++ D+GLA       EY  R  +++   +  PE 
Sbjct: 125 YIERKNYIHRDLRAANVLV-SESLMCKIADFGLARVIE-DNEYTAREGAKFPIKWTAPE- 181

Query: 203 LVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAK 247
            +++  +    D+WS G +L  ++   +  + G  N D +  +++
Sbjct: 182 AINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQ 226


>3PLS-A nrPDB
          Length = 298

 Score = 52.0 bits (123), Expect = 4e-07,   Method: Compositional matrix adjust.
 Identities = 51/215 (23%), Positives = 99/215 (46%), Gaps = 22/215 (10%)

Query: 43  RKLGRGKYSEVF--EAINITNNE-----KVVVKILKPVKKKKIKREIKILENLRGGPNII 95
           R +G+G +  V+  E I+   N      K + +I +  + +   RE  ++  L   PN++
Sbjct: 27  RVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGL-NHPNVL 85

Query: 96  TLADIVKDPVSRTPALVFEHVNNTDFKQLYQTL----TDYDIRFYMYEILKALDYCHSMG 151
            L  I+  P    P ++  ++ + D  Q  ++     T  D+  +  ++ + ++Y     
Sbjct: 86  ALIGIMLPP-EGLPHVLLPYMCHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLAEQK 144

Query: 152 IMHRDVKPHNVMIDHEHRKLRLIDWGLA------EFYHPGQEYNVRVASRYFKGPELLVD 205
            +HRD+   N M+D E   +++ D+GLA      E+Y   Q  + R+  ++    E L  
Sbjct: 145 FVHRDLAARNCMLD-ESFTVKVADFGLARDILDREYYSVQQHRHARLPVKW-TALESLQT 202

Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYD 240
           Y+    S D+WS G +L  ++ R  P +   D +D
Sbjct: 203 YRFTTKS-DVWSFGVLLWELLTRGAPPYRHIDPFD 236


>3PP0-A nrPDB
          Length = 338

 Score = 52.0 bits (123), Expect = 5e-07,   Method: Compositional matrix adjust.
 Identities = 73/308 (23%), Positives = 133/308 (43%), Gaps = 41/308 (13%)

Query: 42  VRKLGRGKYSEVFEAINITNNEKV----VVKILK----PVKKKKIKREIKILENLRGGPN 93
           V+ LG G +  V++ I I + E V     +K+L+    P   K+I  E  ++  + G P 
Sbjct: 22  VKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGV-GSPY 80

Query: 94  I-----ITLADIVKDPVSRTP-ALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYC 147
           +     I L   V+      P   + +HV     +     L   D+  +  +I K + Y 
Sbjct: 81  VSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGR-----LGSQDLLNWCMQIAKGMSYL 135

Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ-EYNV---RVASRYFKGPELL 203
             + ++HRD+   NV++   +  +++ D+GLA      + EY+    +V  ++     +L
Sbjct: 136 EDVRLVHRDLAARNVLVKSPNH-VKITDFGLARLLDIDETEYHADGGKVPIKWMALESIL 194

Query: 204 VDYQMYDYSLDMWSLGCMLAS-MIFRKEPF--FHGHDNYDQLVRIAKV----LGTEDLYD 256
              + + +  D+WS G  +   M F  +P+      +  D L +  ++    + T D+Y 
Sbjct: 195 --RRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYM 252

Query: 257 YIDKY---NIELDPRFNDILGRHSR--KRWERFVHSENQHLVSPEALD--FLDKLLRYDH 309
            + K    + E  PRF +++   SR  +  +RFV  +N+ L     LD  F   LL  D 
Sbjct: 253 IMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDD 312

Query: 310 QSRLTARE 317
              L   E
Sbjct: 313 MGDLVDAE 320


>2CMW-A nrPDB
          Length = 310

 Score = 52.0 bits (123), Expect = 5e-07,   Method: Compositional matrix adjust.
 Identities = 41/153 (26%), Positives = 74/153 (48%), Gaps = 19/153 (12%)

Query: 43  RKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK--KIKREIKILENL----RGGPNIIT 96
           +K+G G + E+    N+  NE V +K L+P+K +  ++  E +  + L     G P +  
Sbjct: 6   KKIGCGNFGELRLGKNLYTNEYVAIK-LEPIKSRAPQLHLEYRFYKQLGSAGEGLPQVYY 64

Query: 97  LADIVKDPVSRTPALVFEHVNNTD---FKQLYQTLTDYDIRFYMYEILKALDYCHSMGIM 153
                  P  +  A+V E +  +    F    +T T   +     ++L  ++Y HS  ++
Sbjct: 65  FG-----PCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYVHSKNLI 119

Query: 154 HRDVKPHNVMIDHEHRK----LRLIDWGLAEFY 182
           +RDVKP N +I  +  K    + +ID+GLA+ Y
Sbjct: 120 YRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEY 152


>5HLW-A nrPDB
          Length = 299

 Score = 51.6 bits (122), Expect = 5e-07,   Method: Compositional matrix adjust.
 Identities = 58/261 (22%), Positives = 115/261 (44%), Gaps = 34/261 (13%)

Query: 45  LGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIK------ILENLRGGPNIITLA 98
           +GRG +  V+    + N+ K +   +K + +     E+       I+      PN+++L 
Sbjct: 28  IGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLL 87

Query: 99  DIVKDPVSRTPALVFEHVNNTDFKQLYQTLTD----YDIRFYMYEILKALDYCHSMGIMH 154
            I       +P +V  ++ + D +   +  T      D+  +  ++ K + Y  S   +H
Sbjct: 88  GICLRS-EGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVH 146

Query: 155 RDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDY-------- 206
           RD+   N M+D E   +++ D+GLA   H  + Y+V   +    G +L V +        
Sbjct: 147 RDLAARNCMLD-EKFTVKVADFGLARDMHDKEYYSVHNKT----GAKLPVKWMALESLQT 201

Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYD---QLVRIAKVLGTE----DLYDYID 259
           Q +    D+WS G +L  ++ R  P +   + +D    L++  ++L  E     LY+ + 
Sbjct: 202 QKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVML 261

Query: 260 KY---NIELDPRFNDILGRHS 277
           K      E+ P F++++ R S
Sbjct: 262 KCWHPKAEMRPSFSELVSRIS 282


>5X02-A nrPDB
          Length = 347

 Score = 51.6 bits (122), Expect = 6e-07,   Method: Compositional matrix adjust.
 Identities = 59/251 (23%), Positives = 107/251 (42%), Gaps = 54/251 (21%)

Query: 12  YTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEA----INITN-NEKVV 66
           Y D   +     W++    +E+G        + LG G + +V  A    I+ T  + +V 
Sbjct: 31  YVDFREYEYDLKWEFPRENLEFG--------KVLGSGAFGKVMNATAYGISKTGVSIQVA 82

Query: 67  VKILK----PVKKKKIKREIKILENLRGGPNIITL--ADIVKDPVSRTPALVFEHVNNTD 120
           VK+LK      +++ +  E+K++  L    NI+ L  A  +  P+     L+FE+    D
Sbjct: 83  VKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPI----YLIFEYCCYGD 138

Query: 121 F---------------------KQLYQ-----TLTDYDIRFYMYEILKALDYCHSMGIMH 154
                                 K+L +      LT  D+  + Y++ K +++      +H
Sbjct: 139 LLNYLRSKREKFSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVH 198

Query: 155 RDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLVDYQMYDY 211
           RD+   NV++ H  + +++ D+GLA        Y VR  +R    +  PE L +  +Y  
Sbjct: 199 RDLAARNVLVTH-GKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFE-GIYTI 256

Query: 212 SLDMWSLGCML 222
             D+WS G +L
Sbjct: 257 KSDVWSYGILL 267


>2PL0-A nrPDB
          Length = 289

 Score = 51.6 bits (122), Expect = 6e-07,   Method: Compositional matrix adjust.
 Identities = 47/223 (21%), Positives = 102/223 (45%), Gaps = 23/223 (10%)

Query: 15  VNTHRPRE-YWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK-- 71
           + T +P++ +W+ E  V     ++  +LV +LG G++ EV+       + KV VK LK  
Sbjct: 4   MQTQKPQKPWWEDEWEV----PRETLKLVERLGAGQFGEVWMGY-YNGHTKVAVKSLKQG 58

Query: 72  PVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---- 127
            +       E  +++ L+    +   A + ++P+     ++ E++ N       +T    
Sbjct: 59  SMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIY----IITEYMENGSLVDFLKTPSGI 114

Query: 128 -LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ 186
            LT   +     +I + + +      +HRD++  N+++  +    ++ D+GLA       
Sbjct: 115 KLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVS-DTLSCKIADFGLARLIE-DN 172

Query: 187 EYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMI 226
           EY  R  +++   +  PE  ++Y  +    D+WS G +L  ++
Sbjct: 173 EYTAREGAKFPIKWTAPEA-INYGTFTIKSDVWSFGILLTEIV 214


>5TE0-A nrPDB
          Length = 347

 Score = 51.2 bits (121), Expect = 7e-07,   Method: Compositional matrix adjust.
 Identities = 56/215 (26%), Positives = 100/215 (46%), Gaps = 31/215 (14%)

Query: 45  LGRGKYSEVFEAINITNNEKVVVKILKPVKK---KKIKREIKILENLRGGPNIITLADIV 101
           L  G ++ VF  +  +N  K  +K +    +   +  KREI+I+ +L G  NI+   D  
Sbjct: 27  LAEGGFAIVF-LVRTSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSS 85

Query: 102 KDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIR----FYMYEILKAL-DYCHSMG----- 151
            + VS     V+E +   DF +  Q +   + R    F   E+L+   D C ++      
Sbjct: 86  INNVSSGD--VWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQC 143

Query: 152 ---IMHRDVKPHNVMIDHEHRKLRLIDWGLA--EFYHPGQE-YNV------RVASRYFKG 199
              I+HRD+K  N+++ H+     L D+G A  +F +P  E  N       +  +  ++ 
Sbjct: 144 KTPIIHRDLKVENILL-HDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYRA 202

Query: 200 PELLVDY--QMYDYSLDMWSLGCMLASMIFRKEPF 232
           PE++  Y  ++     D+W+LGC+L  + +   PF
Sbjct: 203 PEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPF 237


>5HVK-A nrPDB
          Length = 315

 Score = 51.2 bits (121), Expect = 7e-07,   Method: Compositional matrix adjust.
 Identities = 49/211 (23%), Positives = 102/211 (48%), Gaps = 37/211 (17%)

Query: 45  LGRGKYSEVFEAINITNNEKVVVKILKPV------KKKKIKREIKILENLRGGPNIITLA 98
           LG+G + +   AI +T+ E   V ++K +       ++   +E+K++  L   PN++   
Sbjct: 22  LGKGCFGQ---AIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEH-PNVLKFI 77

Query: 99  DIV-KDPVSRTPALVFEHVNNTDFKQLYQTLTD---YDIRF-YMYEILKALDYCHSMGIM 153
            ++ KD   +    + E++     + + +++     +  R  +  +I   + Y HSM I+
Sbjct: 78  GVLYKD---KRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNII 134

Query: 154 HRDVKPHNVMIDHEHRKLRLIDWGLA-----EFYHP-----------GQEYNVRVASRYF 197
           HR++  HN ++  E++ + + D+GLA     E   P            + Y V V + Y+
Sbjct: 135 HRNLNSHNCLV-RENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTV-VGNPYW 192

Query: 198 KGPELLVDYQMYDYSLDMWSLGCMLASMIFR 228
             PE +++ + YD  +D++S G +L  +I R
Sbjct: 193 MAPE-MINGRSYDEKVDVFSFGIVLCEIIGR 222


>2C47-A nrPDB
          Length = 313

 Score = 51.2 bits (121), Expect = 8e-07,   Method: Compositional matrix adjust.
 Identities = 39/157 (24%), Positives = 75/157 (47%), Gaps = 18/157 (11%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIK-----REIKILENLRGGP 92
           ++++ +K+G G + E+    N+  NE V +K L+P+K +  +     R  K L    G P
Sbjct: 5   NFRVGKKIGCGNFGELRLGKNLYTNEYVAIK-LEPIKSRAPQLHLEYRFYKQLSATEGVP 63

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNTD---FKQLYQTLTDYDIRFYMYEILKALDYCHS 149
            +         P  +  A+V E +  +    F    +T T   +     +++  ++Y H+
Sbjct: 64  QVYYFG-----PCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYVHT 118

Query: 150 MGIMHRDVKPHNVMIDHEHRK----LRLIDWGLAEFY 182
             +++RDVKP N ++     K    + +ID+GLA+ Y
Sbjct: 119 KSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEY 155


>5A46-A nrPDB
          Length = 386

 Score = 51.2 bits (121), Expect = 8e-07,   Method: Compositional matrix adjust.
 Identities = 53/222 (23%), Positives = 98/222 (44%), Gaps = 41/222 (18%)

Query: 36  QDDYQLVRKLGRGKYSEVF--EAINITNNE-----KVVVKILKPVKKKK----IKREIKI 84
           +D   L + LG G + +V   EAI +  ++     KV VK+LK    +K    +  E+++
Sbjct: 39  RDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEM 98

Query: 85  LENLRGGPNIITL--ADIVKDPVSRTPALVFEHVNNTDFKQLYQT--------------- 127
           ++ +    NII L  A     P+     ++ E+ +  + ++  Q                
Sbjct: 99  MKMIGKHKNIINLLGACTQDGPL----YVIVEYASKGNLREYLQARRPPGLEYCYNPSHN 154

Query: 128 ----LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH 183
               L+  D+    Y++ + ++Y  S   +HRD+   NV++  E   +++ D+GLA   H
Sbjct: 155 PEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVT-EDNVMKIADFGLARDIH 213

Query: 184 PGQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCML 222
               Y      R    +  PE L D ++Y +  D+WS G +L
Sbjct: 214 HIDYYKKTTNGRLPVKWMAPEALFD-RIYTHQSDVWSFGVLL 254


>4XUF-A nrPDB
          Length = 297

 Score = 50.8 bits (120), Expect = 9e-07,   Method: Compositional matrix adjust.
 Identities = 57/239 (23%), Positives = 104/239 (43%), Gaps = 54/239 (22%)

Query: 24  WDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEA----INITN-NEKVVVKILK----PVK 74
           W++    +E+G        + LG G + +V  A    I+ T  + +V VK+LK      +
Sbjct: 4   WEFPRENLEFG--------KVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSE 55

Query: 75  KKKIKREIKILENLRGGPNIITL--ADIVKDPVSRTPALVFEHVNNTDF----------- 121
           ++ +  E+K++  L    NI+ L  A  +  P+     L+FE+    D            
Sbjct: 56  REALMSELKMMTQLGSHENIVNLLGACTLSGPI----YLIFEYCCYGDLLNYLRSKREKF 111

Query: 122 ----------KQLYQ-----TLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDH 166
                     K+L +      LT  D+  + Y++ K +++      +HRD+   NV++ H
Sbjct: 112 SEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTH 171

Query: 167 EHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCML 222
             + +++ D+GLA        Y VR  +R    +  PE L +  +Y    D+WS G +L
Sbjct: 172 -GKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFE-GIYTIKSDVWSYGILL 228


>3TT0-A nrPDB
          Length = 382

 Score = 50.8 bits (120), Expect = 1e-06,   Method: Compositional matrix adjust.
 Identities = 53/222 (23%), Positives = 98/222 (44%), Gaps = 41/222 (18%)

Query: 36  QDDYQLVRKLGRGKYSEVF--EAINITNNE-----KVVVKILKPVKKKK----IKREIKI 84
           +D   L + LG G + +V   EAI +  ++     KV VK+LK    +K    +  E+++
Sbjct: 68  RDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEM 127

Query: 85  LENLRGGPNIITL--ADIVKDPVSRTPALVFEHVNNTDFKQLYQT--------------- 127
           ++ +    NII L  A     P+     ++ E+ +  + ++  Q                
Sbjct: 128 MKMIGKHKNIINLLGACTQDGPLY----VIVEYASKGNLREYLQARRPPGLEYSYNPSHN 183

Query: 128 ----LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH 183
               L+  D+    Y++ + ++Y  S   +HRD+   NV++  E   +++ D+GLA   H
Sbjct: 184 PEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVT-EDNVMKIADFGLARDIH 242

Query: 184 PGQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCML 222
               Y      R    +  PE L D ++Y +  D+WS G +L
Sbjct: 243 HIDYYKKTTNGRLPVKWMAPEALFD-RIYTHQSDVWSFGVLL 283


>3GQL-A nrPDB
          Length = 326

 Score = 50.4 bits (119), Expect = 1e-06,   Method: Compositional matrix adjust.
 Identities = 53/222 (23%), Positives = 98/222 (44%), Gaps = 41/222 (18%)

Query: 36  QDDYQLVRKLGRGKYSEVF--EAINITNNE-----KVVVKILKPVKKKK----IKREIKI 84
           +D   L + LG G + +V   EAI +  ++     KV VK+LK    +K    +  E+++
Sbjct: 27  RDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEM 86

Query: 85  LENLRGGPNIITL--ADIVKDPVSRTPALVFEHVNNTDFKQLYQT--------------- 127
           ++ +    NII L  A     P+     ++ E+ +  + ++  Q                
Sbjct: 87  MKMIGKHKNIINLLGACTQDGPLY----VIVEYASKGNLREYLQARRPPGLEYCYNPSHN 142

Query: 128 ----LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH 183
               L+  D+    Y++ + ++Y  S   +HRD+   NV++  E   +++ D+GLA   H
Sbjct: 143 PEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVT-EDNVMKIADFGLARDIH 201

Query: 184 PGQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCML 222
               Y      R    +  PE L D ++Y +  D+WS G +L
Sbjct: 202 HIDYYKKTTNGRLPVKWMAPEALFD-RIYTHQSDVWSFGVLL 242


>5SYS-A nrPDB
          Length = 286

 Score = 50.1 bits (118), Expect = 1e-06,   Method: Compositional matrix adjust.
 Identities = 45/222 (20%), Positives = 98/222 (44%), Gaps = 18/222 (8%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP--VKKKKIKREIKILENLRGGPN 93
           ++  +L  KLG+G + E +         +V +K LKP  +  +   +E ++++ LR    
Sbjct: 17  RESLRLEVKLGQGCFGECWMG-TWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKL 75

Query: 94  IITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRF-----YMYEILKALDYCH 148
           +   A + ++P+     +V E+++        +      +R         +I   + Y  
Sbjct: 76  VQLYAVVSEEPIY----IVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVE 131

Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLVD 205
            M  +HRD++  N+++  E+   ++ D+GLA       EY  R  +++   +  PE  + 
Sbjct: 132 RMNYVHRDLRAANILVG-ENLVCKVADFGLARLIE-DNEYTARQGAKFPIKWTAPEAAL- 188

Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAK 247
           Y  +    D+WS G +L  +  +    + G  N + L ++ +
Sbjct: 189 YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER 230


>2XYN-A nrPDB
          Length = 292

 Score = 50.1 bits (118), Expect = 2e-06,   Method: Compositional matrix adjust.
 Identities = 42/196 (21%), Positives = 89/196 (45%), Gaps = 12/196 (6%)

Query: 35  NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK--PVKKKKIKREIKILENLRGGP 92
            + D  +  KLG G+Y EV+  +    +  V VK LK   ++ ++  +E  +++ ++  P
Sbjct: 30  ERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKH-P 88

Query: 93  NIITLADIVK-DPVSRTPALVFEHVNNTDFKQLY--QTLTDYDIRFYMYEILKALDYCHS 149
           N++ L  +   +P          + N  D+ +    + +T   + +   +I  A++Y   
Sbjct: 89  NLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEK 148

Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLVDY 206
              +HRD+   N ++   H  +++ D+GL+     G  Y     +++   +  PE L  Y
Sbjct: 149 KNFIHRDLAARNCLVGENHV-VKVADFGLSRL-MTGDTYTAHAGAKFPIKWTAPESLA-Y 205

Query: 207 QMYDYSLDMWSLGCML 222
             +    D+W+ G +L
Sbjct: 206 NTFSIKSDVWAFGVLL 221


>4EBW-A nrPDB
          Length = 304

 Score = 49.7 bits (117), Expect = 2e-06,   Method: Compositional matrix adjust.
 Identities = 49/226 (21%), Positives = 100/226 (44%), Gaps = 23/226 (10%)

Query: 35  NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK-------KKKIKREIKILEN 87
            ++  +L R +G G++ +V + I ++     +   +K  K       ++K  +E   +  
Sbjct: 36  QRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQ 95

Query: 88  LRGGPNIITLADIV-KDPVSRTPALVFEHVNNTDFKQLYQ----TLTDYDIRFYMYEILK 142
               P+I+ L  ++ ++PV     ++ E     + +   Q    +L    +  Y Y++  
Sbjct: 96  F-DHPHIVKLIGVITENPV----WIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLST 150

Query: 143 ALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFK--GP 200
           AL Y  S   +HRD+   NV++   +  ++L D+GL+ +      Y         K   P
Sbjct: 151 ALAYLESKRFVHRDIAARNVLVS-SNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAP 209

Query: 201 ELLVDYQMYDYSLDMWSLG-CMLASMIFRKEPFFHGHDNYDQLVRI 245
           E  ++++ +  + D+W  G CM   ++   +P F G  N D + RI
Sbjct: 210 E-SINFRRFTSASDVWMFGVCMWEILMHGVKP-FQGVKNNDVIGRI 253


>3KRL-A nrPDB
          Length = 335

 Score = 49.7 bits (117), Expect = 2e-06,   Method: Compositional matrix adjust.
 Identities = 52/219 (23%), Positives = 95/219 (43%), Gaps = 37/219 (16%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNE-----KVVVKILKPV----KKKKIKREIKILE 86
           +++ Q  + LG G + +V EA      +     KV VK+LK      +K+ +  E+KI+ 
Sbjct: 45  RNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMS 104

Query: 87  NLRGGPNIITLADIVK--DPV------------------SRTPALVFEHVNNTDFKQLYQ 126
           +L    NI+ L        PV                   R P L + +  + + ++   
Sbjct: 105 HLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKRPPGLEYSYNPSHNPEE--- 161

Query: 127 TLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ 186
            L+  D+  +  ++ + + +  S   +HRDV   NV++ + H   ++ D+GLA       
Sbjct: 162 QLSSRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVA-KIGDFGLARDIMNDS 220

Query: 187 EYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCML 222
            Y V+  +R    +  PE + D  +Y    D+WS G +L
Sbjct: 221 NYIVKGNARLPVKWMAPESIFDC-VYTVQSDVWSYGILL 258


>5GRN-A nrPDB
          Length = 356

 Score = 49.7 bits (117), Expect = 2e-06,   Method: Compositional matrix adjust.
 Identities = 58/227 (25%), Positives = 99/227 (43%), Gaps = 43/227 (18%)

Query: 36  QDDYQLVRKLGRGKYSEVFE--AINITNNE---KVVVKILKPV----KKKKIKREIKILE 86
           +D   L R LG G + +V E  A  ++ ++   KV VK+LKP     +K+ +  E+KI+ 
Sbjct: 45  RDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMT 104

Query: 87  NLRGGPNIITL--ADIVKDPVSRTPALVFE-------HVNNTDF-------------KQL 124
           +L    NI+ L  A     P+       F        H N   F             K L
Sbjct: 105 HLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHKKKSMLDSEVKNL 164

Query: 125 Y-----QTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA 179
                 + LT  D+  + Y++ + +++  S   +HRD+   NV++  + + +++ D+GLA
Sbjct: 165 LSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLL-AQGKIVKICDFGLA 223

Query: 180 EFYHPGQEYNVRVASRY----FKGPELLVDYQMYDYSLDMWSLGCML 222
                   Y V   S +    +  PE + D  +Y    D+WS G +L
Sbjct: 224 RDIMHDSNY-VSKGSTFLPVKWMAPESIFD-NLYTTLSDVWSYGILL 268


>2A1A-B nrPDB
          Length = 284

 Score = 49.7 bits (117), Expect = 2e-06,   Method: Compositional matrix adjust.
 Identities = 55/232 (23%), Positives = 105/232 (45%), Gaps = 31/232 (13%)

Query: 28  SHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILEN 87
           +H V+     D++ +  +G G + +VF+A +  + +  V+K +K    +K +RE+K L  
Sbjct: 2   AHTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVK-YNNEKAEREVKALAK 60

Query: 88  LRGGPNIITLADI-----------VKDPVSRTPALVFEHVNNTDFKQLYQTLT------- 129
           L    NI+                 K+        +F  +   D   L Q +        
Sbjct: 61  L-DHVNIVHYNGCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKL 119

Query: 130 DYDIRFYMYE-ILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGL-AEFYHPGQE 187
           D  +   ++E I K +DY HS  +++RD+KP N+ +  + +++++ D+GL     + G+ 
Sbjct: 120 DKVLALELFEQITKGVDYIHSKKLINRDLKPSNIFL-VDTKQVKIGDFGLVTSLKNDGKR 178

Query: 188 YNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMI------FRKEPFF 233
              +   RY   PE  +  Q Y   +D+++LG +LA ++      F    FF
Sbjct: 179 TRSKGTLRYM-SPE-QISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFF 228


>2OGV-A nrPDB
          Length = 317

 Score = 49.7 bits (117), Expect = 2e-06,   Method: Compositional matrix adjust.
 Identities = 53/213 (24%), Positives = 92/213 (43%), Gaps = 31/213 (14%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNE-----KVVVKILKPV----KKKKIKREIKILE 86
           +++ Q  + LG G + +V EA      +     KV VK+LK      +K+ +  E+KI+ 
Sbjct: 37  RNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMS 96

Query: 87  NLRGGPNIITLADIVKDPVSRTPALVF-EHVNNTDF-------------KQLYQTLTDYD 132
           +L    NI+ L           P LV  E+    D              K+  + L   D
Sbjct: 97  HLGQHENIVNLLGAC---THGGPVLVITEYCCYGDLLNFLRRKAEADLDKEDGRPLELRD 153

Query: 133 IRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRV 192
           +  +  ++ + + +  S   +HRDV   NV++ + H   ++ D+GLA        Y V+ 
Sbjct: 154 LLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVA-KIGDFGLARDIMNDSNYIVKG 212

Query: 193 ASRY---FKGPELLVDYQMYDYSLDMWSLGCML 222
            +R    +  PE + D  +Y    D+WS G +L
Sbjct: 213 NARLPVKWMAPESIFDC-VYTVQSDVWSYGILL 244


>4TN6-A nrPDB
          Length = 318

 Score = 49.3 bits (116), Expect = 3e-06,   Method: Compositional matrix adjust.
 Identities = 41/154 (26%), Positives = 77/154 (50%), Gaps = 8/154 (5%)

Query: 34  GNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK--KIKREIKILENLRGG 91
           GN+  Y+L RK+G G + +++   +I   E+V +K L+ VK K  ++  E KI + ++GG
Sbjct: 6   GNR--YRLGRKIGSGSFGDIYLGTDIAAGEEVAIK-LECVKTKHPQLHIESKIYKMMQGG 62

Query: 92  PNIITLADIVKDPVSRTPALVFEHVNNTD-FKQLYQTLTDYDIRFYMYEILKALDYCHSM 150
             I T+     +       +     +  D F    +  +   +     +++  ++Y HS 
Sbjct: 63  VGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSK 122

Query: 151 GIMHRDVKPHNVM--IDHEHRKLRLIDWGLAEFY 182
             +HRDVKP N +  +  +   + +ID+GLA+ Y
Sbjct: 123 NFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKY 156


>6GQK-A nrPDB
          Length = 328

 Score = 48.9 bits (115), Expect = 4e-06,   Method: Compositional matrix adjust.
 Identities = 50/210 (23%), Positives = 90/210 (42%), Gaps = 33/210 (15%)

Query: 43  RKLGRGKYSEVFEA-----INITNNEKVVVKILKP----VKKKKIKREIKILENLRGGPN 93
           + LG G + +V EA     I       V VK+LKP     +++ +  E+K+L  L    N
Sbjct: 47  KTLGAGAFGKVVEATAQGLIKSDAAMTVAVKMLKPSAHSTEREALMSELKVLSYLGNHEN 106

Query: 94  IITLAD---------IVKDPVSRTPALVFEHVNNTDF-------KQLYQT-LTDYDIRFY 136
           I+ L           ++ +       L F      +F       + LY+  LT   +  +
Sbjct: 107 IVNLLGACTHGGPTLVITEYCCYGDLLNFLRRKRDEFVPYKVAPEDLYKDFLTLEHLLSF 166

Query: 137 MYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEY----NVRV 192
            Y++ K + +  S   +HRD+   N+++ H +   ++ D+GLA        Y    N R+
Sbjct: 167 SYQVAKGMAFLASKNCIHRDLAARNILLTHGNIT-KICDFGLARDIKNDSNYVDKGNARL 225

Query: 193 ASRYFKGPELLVDYQMYDYSLDMWSLGCML 222
             ++   PE + +  +Y +  D+WS G  L
Sbjct: 226 PVKWM-APESIFN-SVYTFESDVWSYGIFL 253


>3MY0-A nrPDB
          Length = 305

 Score = 48.9 bits (115), Expect = 4e-06,   Method: Compositional matrix adjust.
 Identities = 58/215 (26%), Positives = 91/215 (42%), Gaps = 34/215 (15%)

Query: 41  LVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILEN-LRGGPNIITLAD 99
           LV  +G+G+Y EV+    + + E V VKI     ++   RE +I    L    NI  L  
Sbjct: 12  LVECVGKGRYGEVWRG--LWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNI--LGF 67

Query: 100 IVKDPVSRTPALVF-------EHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCH---- 148
           I  D  SR  +          EH +  DF Q  QTL  +            L + H    
Sbjct: 68  IASDMTSRNSSTQLWLITHYHEHGSLYDFLQ-RQTLEPHLALRLAVSAACGLAHLHVEIF 126

Query: 149 ----SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEY-----NVRVASRYFKG 199
                  I HRD K  NV++   + +  + D GLA  +  G +Y     N RV ++ +  
Sbjct: 127 GTQGKPAIAHRDFKSRNVLVK-SNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMA 185

Query: 200 PELLVD------YQMYDYSLDMWSLGCMLASMIFR 228
           PE+L +      ++ Y ++ D+W+ G +L  +  R
Sbjct: 186 PEVLDEQIRTDCFESYKWT-DIWAFGLVLWEIARR 219


>5IKW-A nrPDB
          Length = 310

 Score = 48.9 bits (115), Expect = 4e-06,   Method: Compositional matrix adjust.
 Identities = 45/176 (25%), Positives = 80/176 (45%), Gaps = 22/176 (12%)

Query: 78  IKREIKILENLRGGPNIITLADIVKDPVSRTPALVF--------EHVNNTDFKQLYQTLT 129
            KREI I++ L G  NI+   D   + +S     V           V N   K+L    T
Sbjct: 57  CKREITIMKELSGHKNIVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFT 116

Query: 130 DYDIRFYMYEILKALDYCHSMG--IMHRDVKPHNVMIDHEHRKLRLIDWGLA--EFYHPG 185
           + ++     +  +A+   H     I+HRD+K  N++++ +     L D+G A  +F +P 
Sbjct: 117 EPEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLN-DGGNYVLCDFGSATNKFLNPQ 175

Query: 186 QE-YNV------RVASRYFKGPELLVDY--QMYDYSLDMWSLGCMLASMIFRKEPF 232
           ++  NV      +  +  ++ PE++  Y  +      D+W+LGC+L  + F   PF
Sbjct: 176 KDGVNVVEEEIKKYTTLSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPF 231


>1S9I-A nrPDB
          Length = 354

 Score = 48.9 bits (115), Expect = 4e-06,   Method: Compositional matrix adjust.
 Identities = 48/208 (23%), Positives = 90/208 (43%), Gaps = 22/208 (10%)

Query: 37  DDYQLVRKLGRGKYSEVFEA----INITNNEKVVVKILKPVKKKKIKREIKILENLRGGP 92
           DD++ + +LG G    V +       +    K++   +KP  + +I RE+++L      P
Sbjct: 16  DDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNS-P 74

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYCHS 149
            I+              ++  EH++     Q+ +    + +  +      +L+ L Y   
Sbjct: 75  YIVGFYGAFYS--DGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLRE 132

Query: 150 M-GIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ----EYNVRVASRYFKGPELLV 204
              IMHRDVKP N++++    +++L D+G++     GQ      N  V +R +  PE L 
Sbjct: 133 KHQIMHRDVKPSNILVN-SRGEIKLCDFGVS-----GQLIDSMANSFVGTRSYMAPERLQ 186

Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPF 232
               Y    D+WS+G  L  +   + P 
Sbjct: 187 GTH-YSVQSDIWSMGLSLVELAVGRYPI 213


>3UIU-A nrPDB
          Length = 306

 Score = 48.9 bits (115), Expect = 4e-06,   Method: Compositional matrix adjust.
 Identities = 30/102 (29%), Positives = 55/102 (53%), Gaps = 10/102 (9%)

Query: 139 EILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGL-AEFYHPGQEYNVRVASRYF 197
           +I K +DY HS  ++HRD+KP N+ +  + +++++ D+GL     + G+    +   RY 
Sbjct: 144 QITKGVDYIHSKKLIHRDLKPSNIFL-VDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYM 202

Query: 198 KGPELLVDYQMYDYSLDMWSLGCMLASMI------FRKEPFF 233
             PE  +  Q Y   +D+++LG +LA ++      F    FF
Sbjct: 203 -SPE-QISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFF 242


>2CHL-A nrPDB
          Length = 351

 Score = 48.5 bits (114), Expect = 5e-06,   Method: Compositional matrix adjust.
 Identities = 38/154 (24%), Positives = 76/154 (49%), Gaps = 12/154 (7%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK--KIKREIKILENLRGGPNII 95
           ++++ +K+G G + E+    N+  NE V +K L+P+K +  ++  E +  + L  G  I 
Sbjct: 31  NFRVGKKIGCGNFGELRLGKNLYTNEYVAIK-LEPMKSRAPQLHLEYRFYKQLGSGDGIP 89

Query: 96  TLADIVKDPVSRTPALVFEHVNNTD---FKQLYQTLTDYDIRFYMYEILKALDYCHSMGI 152
            +      P  +  A+V E +  +    F    +T +   +     +++  ++Y HS  +
Sbjct: 90  QVYYF--GPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNL 147

Query: 153 MHRDVKPHNVMIDHEHRK----LRLIDWGLAEFY 182
           ++RDVKP N +I     K    + +ID+ LA+ Y
Sbjct: 148 IYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEY 181


>2HK5-A nrPDB
          Length = 270

 Score = 48.5 bits (114), Expect = 5e-06,   Method: Compositional matrix adjust.
 Identities = 44/203 (21%), Positives = 92/203 (45%), Gaps = 22/203 (10%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP--VKKKKIKREIKILENLRGGPN 93
           ++  +L +KLG G++ EV+ A     + KV VK +KP  +  +    E  +++ L+    
Sbjct: 14  RESLKLEKKLGAGQFGEVWMA-TYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKL 72

Query: 94  IITLADIVKDPV-------SRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDY 146
           +   A + K+P+       ++   L F   +    KQ    L D+       +I + + +
Sbjct: 73  VKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGS-KQPLPKLIDFSA-----QIAEGMAF 126

Query: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELL 203
                 +HRD++  N+++       ++ D+GLA       EY  R  +++   +  PE  
Sbjct: 127 IEQRNYIHRDLRAANILVSA-SLVCKIADFGLARVIE-DNEYTAREGAKFPIKWTAPE-A 183

Query: 204 VDYQMYDYSLDMWSLGCMLASMI 226
           +++  +    D+WS G +L  ++
Sbjct: 184 INFGSFTIKSDVWSFGILLMEIV 206


>4TPT-A nrPDB
          Length = 303

 Score = 48.1 bits (113), Expect = 6e-06,   Method: Compositional matrix adjust.
 Identities = 49/214 (22%), Positives = 99/214 (46%), Gaps = 42/214 (19%)

Query: 45  LGRGKYSEVFEAINITNNEKVVVKILKPV------KKKKIKREIKILENLRGGPNIITLA 98
           LG+G + +   AI +T+     V ++K +       +K    E+K++ +L   PN++   
Sbjct: 8   LGKGFFGQ---AIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSL-DHPNVLKFI 63

Query: 99  DIV-KDPVSRTPALVFEHVNNTDFKQLYQTLTDY----DIRFYMYEILKALDYCHSMGIM 153
            ++ KD   +   L+ E++     K   +++  +     +RF    I   + Y HSM I+
Sbjct: 64  GVLYKD---KKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRF-AKGIASGMAYLHSMCII 119

Query: 154 HRDVKPHNVMIDHEHRKLRLIDWGLAEFY------HPGQEYNVR---------------V 192
           HRD+  HN +I  + + + + D+GL+          P ++   +               V
Sbjct: 120 HRDLNSHNCLIKLD-KTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVV 178

Query: 193 ASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMI 226
            + Y+  PE+L + + YD ++D++S G +L  +I
Sbjct: 179 GNPYWMAPEML-NGKSYDETVDIFSFGIVLCEII 211


>3DTC-A nrPDB
          Length = 271

 Score = 48.1 bits (113), Expect = 6e-06,   Method: Compositional matrix adjust.
 Identities = 53/209 (25%), Positives = 97/209 (46%), Gaps = 30/209 (14%)

Query: 45  LGRGKYSEVFEAINITNNEKVVVKILK-------PVKKKKIKREIKILENLRGGPNIITL 97
           +G G + +V+ A  I   ++V VK  +           + +++E K+   L+  PNII L
Sbjct: 15  IGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKH-PNIIAL 71

Query: 98  ADI-VKDPVSRTPALVFEHVNNTDFKQ-LYQTLTDYDIRF-YMYEILKALDYCHS---MG 151
             + +K+P      LV E        + L       DI   +  +I + ++Y H    + 
Sbjct: 72  RGVCLKEP---NLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVP 128

Query: 152 IMHRDVKPHNVMI-------DHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY-FKGPELL 203
           I+HRD+K  N++I       D  ++ L++ D+GLA  +H  +   +  A  Y +  PE+ 
Sbjct: 129 IIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWH--RTTKMSAAGAYAWMAPEV- 185

Query: 204 VDYQMYDYSLDMWSLGCMLASMIFRKEPF 232
           +   M+    D+WS G +L  ++  + PF
Sbjct: 186 IRASMFSKGSDVWSYGVLLWELLTGEVPF 214


>3PPZ-A nrPDB
          Length = 309

 Score = 48.1 bits (113), Expect = 7e-06,   Method: Compositional matrix adjust.
 Identities = 57/225 (25%), Positives = 108/225 (48%), Gaps = 33/225 (14%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL-----KPVKKKKIKREIKILENLRGGP 92
           D  +  K+G G +  V  A    +   V VKIL        +  +  RE+ I++ LR  P
Sbjct: 38  DLNIKEKIGAGSFGTVHRAE--WHGSDVAVKILMEQDFHAERVNEFLREVAIMKRLRH-P 94

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNTDFKQLY-----QTLTDYDIRFYM-YEILKALDY 146
           NI+     V  P + +  +V E+++     +L      +   D   R  M Y++ K ++Y
Sbjct: 95  NIVLFMGAVTQPPNLS--IVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAKGMNY 152

Query: 147 CHSMG--IMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKG----- 199
            H+    I+HRD+K  N+++D ++  +++ D+GL+       + +  ++S+   G     
Sbjct: 153 LHNRNPPIVHRDLKSPNLLVDKKY-TVKVCDFGLSRL-----KASTFLSSKSAAGTPEWM 206

Query: 200 -PELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLV 243
            PE+L D    + S D++S G +L  +   ++P+  G+ N  Q+V
Sbjct: 207 APEVLRDEPSNEKS-DVYSFGVILWELATLQQPW--GNLNPAQVV 248


>4UYA-A nrPDB
          Length = 340

 Score = 48.1 bits (113), Expect = 7e-06,   Method: Compositional matrix adjust.
 Identities = 46/214 (21%), Positives = 95/214 (44%), Gaps = 24/214 (11%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK-------PVKKKKIKREIKILENLR 89
           +  +L   +G G + +V+ A      ++V VK  +           + ++RE ++   LR
Sbjct: 26  ERLELKELIGAGGFGQVYRAT--WQGQEVAVKAARQDPEQDAAAAAESVRREARLFAMLR 83

Query: 90  GGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHS 149
             PNII L  +          L F      +     + +  + +  +  +I + + Y H 
Sbjct: 84  H-PNIIELRGVCLQQPHLCLVLEFARGGALNRALAGRRIPPHVLVNWAVQIARGMLYLHE 142

Query: 150 MG---IMHRDVKPHNVM----IDHE---HRKLRLIDWGLAEFYHPGQEYNVRVASRY-FK 198
                I+HRD+K  N++    I+H+   ++ L++ D+GLA  +H  +   +  A  Y + 
Sbjct: 143 EAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWH--RTTKMATAGAYAWM 200

Query: 199 GPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPF 232
            PE ++   ++    D+WS G +L  ++  + P+
Sbjct: 201 APE-VIKSSLFSKGSDIWSYGVLLWELLTGEVPY 233


>2J0K-A nrPDB
          Length = 656

 Score = 47.8 bits (112), Expect = 8e-06,   Method: Compositional matrix adjust.
 Identities = 49/221 (22%), Positives = 97/221 (43%), Gaps = 23/221 (10%)

Query: 40  QLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK-------KKKIKREIKILENLRGGP 92
           +L R +G G++ +V + I ++     +   +K  K       ++K  +E   +      P
Sbjct: 393 ELGRCIGEGQFGDVHQGIYMSPENPAMAVAIKTCKNCTSDSVREKFLQEALTMRQF-DHP 451

Query: 93  NIITLADIV-KDPVSRTPALVFEHVNNTDFKQLYQ----TLTDYDIRFYMYEILKALDYC 147
           +I+ L  ++ ++PV     ++ E     + +   Q    +L    +  Y Y++  AL Y 
Sbjct: 452 HIVKLIGVITENPV----WIIMELCTLGELRSFLQVRKFSLDLASLILYAYQLSTALAYL 507

Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFK--GPELLVD 205
            S   +HRD+   NV++      ++L D+GL+ +      Y         K   PE  ++
Sbjct: 508 ESKRFVHRDIAARNVLVSATD-CVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPE-SIN 565

Query: 206 YQMYDYSLDMWSLG-CMLASMIFRKEPFFHGHDNYDQLVRI 245
           ++ +  + D+W  G CM   ++   +P F G  N D + RI
Sbjct: 566 FRRFTSASDVWMFGVCMWEILMHGVKP-FQGVKNNDVIGRI 605


>5B2L-A nrPDB
          Length = 324

 Score = 47.8 bits (112), Expect = 8e-06,   Method: Compositional matrix adjust.
 Identities = 30/111 (27%), Positives = 55/111 (49%), Gaps = 6/111 (5%)

Query: 140 ILKALDYCHSM-GIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFK 198
           I+KAL Y     G++HRDVKP N+++D E  +++L D+G++      +          + 
Sbjct: 125 IVKALYYLKEKHGVIHRDVKPSNILLD-ERGQIKLCDFGISGRLVDSKAKTRSAGCAAYM 183

Query: 199 GPELL----VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRI 245
            PE +         YD   D+WSLG  L  +   + P+ +   +++ L ++
Sbjct: 184 APERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKV 234


>4UY9-A nrPDB
          Length = 323

 Score = 47.4 bits (111), Expect = 1e-05,   Method: Compositional matrix adjust.
 Identities = 53/209 (25%), Positives = 96/209 (45%), Gaps = 30/209 (14%)

Query: 45  LGRGKYSEVFEAINITNNEKVVVKILK-------PVKKKKIKREIKILENLRGGPNIITL 97
           +G G + +V+ A  I   ++V VK  +           + +++E K+   L+  PNII L
Sbjct: 17  IGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKH-PNIIAL 73

Query: 98  ADI-VKDPVSRTPALVFEHVNNTDFKQ-LYQTLTDYDIRF-YMYEILKALDYCHSMGI-- 152
             + +K+P      LV E        + L       DI   +  +I + ++Y H   I  
Sbjct: 74  RGVCLKEP---NLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVP 130

Query: 153 -MHRDVKPHNVMI-------DHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY-FKGPELL 203
            +HRD+K  N++I       D  ++ L++ D+GLA  +H  +   +  A  Y +  PE+ 
Sbjct: 131 IIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWH--RTTKMSAAGTYAWMAPEV- 187

Query: 204 VDYQMYDYSLDMWSLGCMLASMIFRKEPF 232
           +   M+    D+WS G +L  ++  + PF
Sbjct: 188 IRASMFSKGSDVWSYGVLLWELLTGEVPF 216


>4K33-A nrPDB
          Length = 325

 Score = 47.4 bits (111), Expect = 1e-05,   Method: Compositional matrix adjust.
 Identities = 29/100 (29%), Positives = 50/100 (50%), Gaps = 5/100 (5%)

Query: 126 QTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPG 185
           + LT  D+    Y++ + ++Y  S   +HRD+   NV++  E   +++ D+GLA   H  
Sbjct: 153 EQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLV-TEDNVMKIADFGLARDVHNL 211

Query: 186 QEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCML 222
             Y      R    +  PE L D ++Y +  D+WS G +L
Sbjct: 212 DYYKETTNGRLPVKWMAPEALFD-RVYTHQSDVWSFGVLL 250


>4EUU-A nrPDB
          Length = 319

 Score = 47.4 bits (111), Expect = 1e-05,   Method: Compositional matrix adjust.
 Identities = 48/214 (22%), Positives = 93/214 (43%), Gaps = 33/214 (15%)

Query: 45  LGRGKYSEVFE----------AINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNI 94
           LG+G  + VF           AI + NN    +  L+PV  +   RE ++L+ L    NI
Sbjct: 17  LGQGATANVFRGRHKKTGDLFAIKVFNN----ISFLRPVDVQM--REFEVLKKLNH-KNI 69

Query: 95  ITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT------LTDYDIRFYMYEILKALDYCH 148
           + L  I ++  +R   L+ E         + +       L + +    + +++  +++  
Sbjct: 70  VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 129

Query: 149 SMGIMHRDVKPHNVM--IDHEHRKL-RLIDWGLAEFYHPGQEYNVRVASRYFKGPE---- 201
             GI+HR++KP N+M  I  + + + +L D+G A      +++     +  +  P+    
Sbjct: 130 ENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYER 189

Query: 202 --LLVDYQ-MYDYSLDMWSLGCMLASMIFRKEPF 232
             L  D+Q  Y  ++D+WS+G           PF
Sbjct: 190 AVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 223


>3C1X-A nrPDB
          Length = 373

 Score = 47.0 bits (110), Expect = 1e-05,   Method: Compositional matrix adjust.
 Identities = 61/293 (20%), Positives = 123/293 (41%), Gaps = 31/293 (10%)

Query: 11  VYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL 70
           V+ D++   P E      HVV   +         +GRG +  V+    + N+ K +   +
Sbjct: 64  VHIDLSALNP-ELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAV 122

Query: 71  KPVKKKKIKREIK------ILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQL 124
           K + +     E+       I+      PN+++L  I       +P +V  ++ + D +  
Sbjct: 123 KSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRS-EGSPLVVLPYMKHGDLRNF 181

Query: 125 YQTLTD----YDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA- 179
            +  T      D+  +  ++ K + +  S   +HRD+   N M+D E   +++ D+GLA 
Sbjct: 182 IRNETHNPTVKDLIGFGLQVAKGMKFLASKKFVHRDLAARNCMLD-EKFTVKVADFGLAR 240

Query: 180 -----EFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFH 234
                EF     +   ++  ++     L    Q +    D+WS G +L  ++ R  P + 
Sbjct: 241 DMYDKEFDSVHNKTGAKLPVKWMALESL--QTQKFTTKSDVWSFGVLLWELMTRGAPPYP 298

Query: 235 GHDNYD---QLVRIAKVLGTE----DLYDYIDKY---NIELDPRFNDILGRHS 277
             + +D    L++  ++L  E     LY+ + K      E+ P F++++ R S
Sbjct: 299 DVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRIS 351


>3G0E-A nrPDB
          Length = 336

 Score = 47.0 bits (110), Expect = 1e-05,   Method: Compositional matrix adjust.
 Identities = 60/263 (22%), Positives = 104/263 (39%), Gaps = 53/263 (20%)

Query: 11  VYTDVNTHRPREY-WDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEA-----INITNNEK 64
           VY D  T  P ++ W++  + + +G        + LG G + +V EA     I       
Sbjct: 28  VYID-PTQLPYDHKWEFPRNRLSFG--------KTLGAGAFGKVVEATAYGLIKSDAAMT 78

Query: 65  VVVKILKP----VKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTD 120
           V VK+LKP     +++ +  E+K+L  L    NI+ L       +     ++ E+    D
Sbjct: 79  VAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACT--IGGPTLVITEYCCYGD 136

Query: 121 FKQLYQTLTDYDI---------------------RFYMYEILKALDYCHSMGIMHRDVKP 159
                +   D  I                       + Y++ K + +  S   +HRD+  
Sbjct: 137 LLNFLRRKRDSFICSKTSPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAA 196

Query: 160 HNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLVDYQMYDYSLDMW 216
            N+++ H  R  ++ D+GLA        Y V+  +R    +  PE + +  +Y +  D+W
Sbjct: 197 RNILLTH-GRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFN-CVYTFESDVW 254

Query: 217 SLGCMLASMIFRKEPFFHGHDNY 239
           S G      IF  E F  G   Y
Sbjct: 255 SYG------IFLWELFSLGSSPY 271


>4EUT-A nrPDB
          Length = 396

 Score = 47.0 bits (110), Expect = 2e-05,   Method: Compositional matrix adjust.
 Identities = 48/214 (22%), Positives = 93/214 (43%), Gaps = 33/214 (15%)

Query: 45  LGRGKYSEVFE----------AINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNI 94
           LG+G  + VF           AI + NN    +  L+PV  +   RE ++L+ L    NI
Sbjct: 17  LGQGATANVFRGRHKKTGDLFAIKVFNN----ISFLRPVDVQM--REFEVLKKLNH-KNI 69

Query: 95  ITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT------LTDYDIRFYMYEILKALDYCH 148
           + L  I ++  +R   L+ E         + +       L + +    + +++  +++  
Sbjct: 70  VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 129

Query: 149 SMGIMHRDVKPHNVM--IDHEHRKL-RLIDWGLAEFYHPGQEYNVRVASRYFKGPE---- 201
             GI+HR++KP N+M  I  + + + +L D+G A      +++     +  +  P+    
Sbjct: 130 ENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYER 189

Query: 202 --LLVDYQ-MYDYSLDMWSLGCMLASMIFRKEPF 232
             L  D+Q  Y  ++D+WS+G           PF
Sbjct: 190 AVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 223


>4OTD-A nrPDB
          Length = 341

 Score = 46.6 bits (109), Expect = 2e-05,   Method: Compositional matrix adjust.
 Identities = 72/307 (23%), Positives = 125/307 (40%), Gaps = 58/307 (18%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP--------VKKKKIKREIKILENL 88
           +D++ +  LGRG + +V  +    + E   +K LK         V+    ++ I      
Sbjct: 12  EDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTS 71

Query: 89  RGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIR--FYMYEILKALDY 146
            G P ++ L    + P       V E+    D      +    + R  FY   ++  L +
Sbjct: 72  AGHPFLVNLFGCFQTP--EHVCFVMEYSAGGDLMLHIHSDVFSEPRAIFYSACVVLGLQF 129

Query: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLVD 205
            H   I++RD+K  N+++D E   +++ D+GL  E    G   +    +  F  PE+L D
Sbjct: 130 LHEHKIVYRDLKLDNLLLDTEG-YVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTD 188

Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIEL 265
              Y  ++D W LG +L  M+  + P F G D              E+++D I       
Sbjct: 189 TS-YTRAVDWWGLGVLLYEMLVGESP-FPGDDE-------------EEVFDSI------- 226

Query: 266 DPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTARE-----AME 320
               ND        R+ RF        +S EA+  + +LLR + + RL + E       +
Sbjct: 227 ---VND------EVRYPRF--------LSAEAIGIMRRLLRRNPERRLGSSERDAEDVKK 269

Query: 321 HPYFYTV 327
            P+F T+
Sbjct: 270 QPFFRTL 276


>5M07-A nrPDB
          Length = 276

 Score = 46.6 bits (109), Expect = 2e-05,   Method: Compositional matrix adjust.
 Identities = 37/156 (23%), Positives = 70/156 (44%), Gaps = 17/156 (10%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK------KKKIKREIKILENLRGGP 92
           Y +VR LG     EV+   +        +K+L P        +++ +RE ++   L   P
Sbjct: 32  YTVVRMLGASAMGEVYLVQHPGFPGWQALKVLSPAMAADDEFRRRFQRETEVAARLFH-P 90

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNTDFKQ-----LYQTLTDYDIRFYMYEILKALDYC 147
           +I+ + D  +        +  ++V+  D  Q         L   ++   +  +  ALDY 
Sbjct: 91  HILEVHD--RGEFDGQLWIAMDYVDGIDATQHMADRFPAVLPVGEVLAIVTAVAGALDYA 148

Query: 148 HSMGIMHRDVKPHNVMIDHEH---RKLRLIDWGLAE 180
           H  G++HRDV P NV++  +    +++ L D+G+A 
Sbjct: 149 HQRGLLHRDVNPANVVLTSQSAGDQRILLADFGIAS 184


>5AMN-A nrPDB
          Length = 299

 Score = 46.2 bits (108), Expect = 2e-05,   Method: Compositional matrix adjust.
 Identities = 28/104 (26%), Positives = 54/104 (51%), Gaps = 5/104 (4%)

Query: 126 QTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPG 185
           + LT  D+  + ++I + + Y   M ++HRD+   N+++  E RK+++ D+GL+   +  
Sbjct: 131 RALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILV-AEGRKMKISDFGLSRDVYEE 189

Query: 186 QEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMI 226
             Y  R   R    +   E L D+ +Y    D+WS G +L  ++
Sbjct: 190 DSYVKRSQGRIPVKWMAIESLFDH-IYTTQSDVWSFGVLLWEIV 232


>4GS6-A nrPDB
          Length = 315

 Score = 46.2 bits (108), Expect = 2e-05,   Method: Compositional matrix adjust.
 Identities = 49/200 (24%), Positives = 86/200 (43%), Gaps = 24/200 (12%)

Query: 45  LGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDP 104
           +GRG +  V +A      +  + +I    ++K    E++ L  +   PNI+ L     +P
Sbjct: 17  VGRGAFGVVCKA-KWRAKDVAIKQIESESERKAFIVELRQLSRVNH-PNIVKLYGACLNP 74

Query: 105 VSRTPALVFEHVNNTDFKQLYQTL---------TDYDIRFYMYEILKALDYCHSM---GI 152
           V     LV E+        LY  L         T      +  +  + + Y HSM    +
Sbjct: 75  V----CLVMEYAEGGS---LYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKAL 127

Query: 153 MHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYS 212
           +HRD+KP N+++      L++ D+G A         N   A+  +  PE+  +   Y   
Sbjct: 128 IHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNKGSAA--WMAPEVF-EGSNYSEK 184

Query: 213 LDMWSLGCMLASMIFRKEPF 232
            D++S G +L  +I R++PF
Sbjct: 185 CDVFSWGIILWEVITRRKPF 204


>4R7H-A nrPDB
          Length = 343

 Score = 46.2 bits (108), Expect = 2e-05,   Method: Compositional matrix adjust.
 Identities = 53/226 (23%), Positives = 92/226 (40%), Gaps = 44/226 (19%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNE-----KVVVKILKPV----KKKKIKREIKILE 86
           +++ Q  + LG G + +V EA      +     KV VK+LK      +K+ +  E+KI+ 
Sbjct: 49  RNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMS 108

Query: 87  NLRGGPNIITLADIVKDPVSRTPALVF-EHVNNTDF------------------------ 121
           +L    NI+ L           P LV  E+    D                         
Sbjct: 109 HLGQHENIVNLLGAC---THGGPVLVITEYCTYGDLLNFLRRKAEAMLGPSLSPGQDPEG 165

Query: 122 --KQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA 179
             K+  + L   D+  +  ++ + + +  S   +HRDV   NV++ + H   ++ D+GLA
Sbjct: 166 LDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVA-KIGDFGLA 224

Query: 180 EFYHPGQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCML 222
                   Y V+  +R    +  PE + D  +Y    D+WS G +L
Sbjct: 225 RDIMNDSNYIVKGNARLPVKWMAPESIFD-SVYTVQSDVWSYGILL 269


>4JLC-A nrPDB
          Length = 657

 Score = 46.2 bits (108), Expect = 2e-05,   Method: Compositional matrix adjust.
 Identities = 46/201 (22%), Positives = 91/201 (45%), Gaps = 33/201 (16%)

Query: 45  LGRGKYSEVFE----------AINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNI 94
           LG+G  + VF           A+ + NN    +  L+PV  +   RE ++L+ L    NI
Sbjct: 16  LGQGATANVFRGRHKKTGDLYAVKVFNN----ISFLRPVDVQM--REFEVLKKL-NHKNI 68

Query: 95  ITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT------LTDYDIRFYMYEILKALDYCH 148
           + L  I ++  +R   L+ E         + +       L + +    + +++  +++  
Sbjct: 69  VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 128

Query: 149 SMGIMHRDVKPHNVM--IDHEHRKL-RLIDWGLAEFYHPGQEYNVRVASRYFKGPE---- 201
             GI+HRD+KP N+M  I  + + + +L D+G A      +++     +  +  P+    
Sbjct: 129 ENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYER 188

Query: 202 --LLVDYQ-MYDYSLDMWSLG 219
             L  D+Q  Y  ++D+WS+G
Sbjct: 189 AVLRKDHQKKYGATVDLWSVG 209


>5FM2-A nrPDB
          Length = 355

 Score = 46.2 bits (108), Expect = 2e-05,   Method: Compositional matrix adjust.
 Identities = 28/104 (26%), Positives = 54/104 (51%), Gaps = 5/104 (4%)

Query: 126 QTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPG 185
           + LT  D+  + ++I + + Y   M ++HRD+   N+++  E RK+++ D+GL+   +  
Sbjct: 186 RALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILV-AEGRKMKISDFGLSRDVYEE 244

Query: 186 QEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMI 226
             Y  R   R    +   E L D+ +Y    D+WS G +L  ++
Sbjct: 245 DSYVKRSQGRIPVKWMAIESLFDH-IYTTQSDVWSFGVLLWEIV 287


>1AD5-A nrPDB
          Length = 438

 Score = 45.8 bits (107), Expect = 4e-05,   Method: Compositional matrix adjust.
 Identities = 45/222 (20%), Positives = 101/222 (45%), Gaps = 35/222 (15%)

Query: 17  THRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP--VK 74
           + +P++ W+ ++  +    ++  +L +KLG G++ EV+ A     + KV VK +KP  + 
Sbjct: 165 SSKPQKPWEKDAWEIP---RESLKLEKKLGAGQFGEVWMA-TYNKHTKVAVKTMKPGSMS 220

Query: 75  KKKIKREIKILENLRGGPNIITLADIVKDPV-------SRTPALVFEHVNNTDFKQLYQT 127
            +    E  +++ L+    +   A + K+P+       ++   L F   +    KQ    
Sbjct: 221 VEAFLAEANVMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGS-KQPLPK 279

Query: 128 LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE 187
           L D+       +I + + +      +HRD++  N+++       ++ D+GLA        
Sbjct: 280 LIDFSA-----QIAEGMAFIEQRNYIHRDLRAANILVS-ASLVCKIADFGLA-------- 325

Query: 188 YNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMI 226
              RV +++   +  PE  +++  +    D+WS G +L  ++
Sbjct: 326 ---RVGAKFPIKWTAPE-AINFGSFTIKSDVWSFGILLMEIV 363


>6NT9-A nrPDB
          Length = 742

 Score = 45.4 bits (106), Expect = 4e-05,   Method: Compositional matrix adjust.
 Identities = 51/219 (23%), Positives = 97/219 (44%), Gaps = 40/219 (18%)

Query: 45  LGRGKYSEVFE----------AINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNI 94
           LG+G  + VF           AI + NN    +  L+PV  +   RE ++L+ L    NI
Sbjct: 15  LGQGATANVFRGRHKKTGDLFAIKVFNN----ISFLRPVDVQM--REFEVLKKL-NHKNI 67

Query: 95  ITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT------LTDYDIRFYMYEILKALDYCH 148
           + L  I ++  +R   L+ E         + +       L + +    + +++  +++  
Sbjct: 68  VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 127

Query: 149 SMGIMHRDVKPHNVM--IDHEHRKL-RLIDWGLAEFYHPGQEYNVRVASRYFKGPE---- 201
             GI+HR++KP N+M  I  + + + +L D+G A      +++     +  +  P+    
Sbjct: 128 ENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYER 187

Query: 202 --LLVDYQ-MYDYSLDMWSLGCML-----ASMIFRKEPF 232
             L  D+Q  Y  ++D+WS+G         S+ FR  PF
Sbjct: 188 AVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFR--PF 224


>2H34-A nrPDB
          Length = 309

 Score = 45.4 bits (106), Expect = 4e-05,   Method: Compositional matrix adjust.
 Identities = 48/205 (23%), Positives = 93/205 (45%), Gaps = 16/205 (7%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILK------PVKKKKIKREIKILENLRGGP 92
           Y+L R +GRG   +V+EA +      V +K++       PV + +++RE +    L+  P
Sbjct: 36  YRLRRLVGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPVFRTRMQREARTAGRLQE-P 94

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYCHS 149
           +++ + D  +  +     +    +N  D   + +    L        + +I  ALD  H+
Sbjct: 95  HVVPIHDFGE--IDGQLYVDMRLINGVDLAAMLRRQGPLAPPRAVAIVRQIGSALDAAHA 152

Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ--EYNVRVASRYFKGPELLVDYQ 207
            G  HRDVKP N+++  +     L+D+G+A      +  +    V + Y+  PE   +  
Sbjct: 153 AGATHRDVKPENILVSADDFAY-LVDFGIASATTDEKLTQLGNTVGTLYYMAPERFSESH 211

Query: 208 MYDYSLDMWSLGCMLASMIFRKEPF 232
              Y  D+++L C+L   +    P+
Sbjct: 212 AT-YRADIYALTCVLYECLTGSPPY 235


>4RT7-A nrPDB
          Length = 415

 Score = 45.4 bits (106), Expect = 4e-05,   Method: Compositional matrix adjust.
 Identities = 28/99 (28%), Positives = 50/99 (50%), Gaps = 5/99 (5%)

Query: 127 TLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ 186
            LT  D+  + Y++ K +++      +HRD+   NV++ H  + +++ D+GLA       
Sbjct: 239 VLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTH-GKVVKICDFGLARDIMSDS 297

Query: 187 EYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCML 222
            Y VR  +R    +  PE L +  +Y    D+WS G +L
Sbjct: 298 NYVVRGNARLPVKWMAPESLFE-GIYTIKSDVWSYGILL 335


>3MDY-A nrPDB
          Length = 337

 Score = 45.4 bits (106), Expect = 5e-05,   Method: Compositional matrix adjust.
 Identities = 55/207 (26%), Positives = 95/207 (45%), Gaps = 28/207 (13%)

Query: 40  QLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILEN-LRGGPNIIT-L 97
           Q+V+++G+G+Y EV+  +     EKV VK+    ++    RE +I +  L    NI+  +
Sbjct: 40  QMVKQIGKGRYGEVW--MGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFI 97

Query: 98  ADIVKDPVSRTPALVFE--HVNNTDFKQLYQTLTDYDIRFYM-YEILKALDYCHSM---- 150
           A  +K   S T   +    H N + +  L  T  D      + Y  +  L + H+     
Sbjct: 98  AADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEIFST 157

Query: 151 ----GIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEY----NVRVASRYFKGPE 201
                I HRD+K  N+++  ++    + D GLA +F     E     N RV ++ +  PE
Sbjct: 158 QGKPAIAHRDLKSKNILV-KKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPE 216

Query: 202 LLVD------YQMYDYSLDMWSLGCML 222
           +L +      +Q Y  + DM+S G +L
Sbjct: 217 VLDESLNRNHFQSYIMA-DMYSFGLIL 242


>1CSN-A nrPDB
          Length = 298

 Score = 45.4 bits (106), Expect = 5e-05,   Method: Compositional matrix adjust.
 Identities = 37/160 (23%), Positives = 73/160 (45%), Gaps = 26/160 (16%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIK-----REIKILENLRGGPN 93
           Y++ R++G G +  +FE  N+ NN++V +K  +P +    +     R  K+L    G PN
Sbjct: 12  YKVGRRIGEGSFGVIFEGTNLLNNQQVAIK-FEPRRSDAPQLRDEYRTYKLLAGCTGIPN 70

Query: 94  IITLAD------IVKDPVSRTPALVFEHVNNTDFKQLY-QTLTDYDIRFYMYEILKALDY 146
           +           +V D +   P+L        D   L  +  +   +     ++L  +  
Sbjct: 71  VYYFGQEGLHNVLVIDLLG--PSL-------EDLLDLCGRKFSVKTVAMAAKQMLARVQS 121

Query: 147 CHSMGIMHRDVKPHNVMIDHEHRK----LRLIDWGLAEFY 182
            H   +++RD+KP N +I   + K    + ++D+G+ +FY
Sbjct: 122 IHEKSLVYRDIKPDNFLIGRPNSKNANMIYVVDFGMVKFY 161


>4NT4-A nrPDB
          Length = 312

 Score = 45.1 bits (105), Expect = 5e-05,   Method: Compositional matrix adjust.
 Identities = 41/158 (25%), Positives = 76/158 (48%), Gaps = 14/158 (8%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIK-----REIKIL-ENLRGG 91
           ++++ +K+G G + E+    N+ NNE V +K ++P+K K  +     R  K+L  +    
Sbjct: 13  NFRVGKKIGCGNFGELRLGKNLYNNEHVAIK-MEPMKSKAPQLHLEYRFYKLLGSHADNA 71

Query: 92  PNIITLADIVKDPVSRTPALVFEHVN---NTDFKQLYQTLTDYDIRFYMYEILKALDYCH 148
           P+ I     +     R  A+V E +       F    +  +   +     ++L  ++Y H
Sbjct: 72  PDGIPRIYHLGTCGGRYNAMVLELLGLSLEDLFNICARKFSLKTVLMIAKQLLHRIEYVH 131

Query: 149 SMGIMHRDVKPHNVMIDHEHRK----LRLIDWGLAEFY 182
           S  +++RDVKP N +I     K    + +ID+GLA+ Y
Sbjct: 132 SRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEY 169


>5CEK-A nrPDB
          Length = 263

 Score = 45.1 bits (105), Expect = 5e-05,   Method: Compositional matrix adjust.
 Identities = 68/288 (23%), Positives = 121/288 (42%), Gaps = 60/288 (20%)

Query: 53  VFEAINITNNEKVVVKILKPVK--KKKIKREIKILENLRGGPNIITLADIVKDPVSRTPA 110
           V  A+ I    ++  K+  P+K  + KI+  I++       P+   +  IV+  +  T A
Sbjct: 25  VSRALCIHTGRELRCKVF-PIKHYQDKIRPYIQL-------PSHSNITGIVEVILGETKA 76

Query: 111 LVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHE 167
            VF   +  D     ++   L + +      +I+ A+ +CH   I+  D+K    +   E
Sbjct: 77  YVFFEKDFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTE 136

Query: 168 HR-KLRLIDWGLAEFYHPGQEYNVRVASRY----FKGPELLVDYQMYD-YSLDMWSLGCM 221
            R +LRL      E  H  +  +  ++ ++    +  PE+L     Y   + D+WSLG M
Sbjct: 137 ERTQLRLESL---EDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVM 193

Query: 222 LASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRW 281
           L +++  + PF   HD+                           DP         S+ R 
Sbjct: 194 LYTLLVGRYPF---HDS---------------------------DPS-----ALFSKIRR 218

Query: 282 ERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 329
            +F   E+   +SP+A   +  LLR +   RLTA E + HP+F +V++
Sbjct: 219 GQFCIPEH---ISPKARCLIRSLLRREPSERLTAPEILLHPWFESVLE 263


>6O8B-A nrPDB
          Length = 665

 Score = 45.1 bits (105), Expect = 5e-05,   Method: Compositional matrix adjust.
 Identities = 46/201 (22%), Positives = 91/201 (45%), Gaps = 33/201 (16%)

Query: 45  LGRGKYSEVFE----------AINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNI 94
           LG+G  + VF           AI + NN    +  L+PV  +   RE ++L+ L    NI
Sbjct: 23  LGQGATANVFRGRHKKTGDLFAIKVFNN----ISFLRPVDVQM--REFEVLKKL-NHKNI 75

Query: 95  ITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT------LTDYDIRFYMYEILKALDYCH 148
           + L  I ++  +R   L+ E         + +       L + +    + +++  +++  
Sbjct: 76  VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 135

Query: 149 SMGIMHRDVKPHNVM--IDHEHRKL-RLIDWGLAEFYHPGQEYNVRVASRYFKGPE---- 201
             GI+HR++KP N+M  I  + + + +L D+G A      +++     +  +  P+    
Sbjct: 136 ENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVELYGTEEYLHPDMYER 195

Query: 202 --LLVDYQ-MYDYSLDMWSLG 219
             L  D+Q  Y  ++D+WS+G
Sbjct: 196 AVLRKDHQKKYGATVDLWSIG 216


>2RIO-A nrPDB
          Length = 434

 Score = 45.1 bits (105), Expect = 6e-05,   Method: Compositional matrix adjust.
 Identities = 47/213 (22%), Positives = 89/213 (41%), Gaps = 57/213 (26%)

Query: 137 MYEILKALDYCHSMGIMHRDVKPHNVMIDHEHR----------KLRLI--DWGLAEFYHP 184
           + +I   + + HS+ I+HRD+KP N+++    R           LR++  D+GL +    
Sbjct: 121 LRQIASGVAHLHSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDS 180

Query: 185 GQE-----YNVRVASRYFKGPELLVDY------QMYDYSLDMWSLGCMLASMIFR-KEPF 232
           GQ       N    +  ++ PELL +       +    S+D++S+GC+   ++ + K PF
Sbjct: 181 GQSSFRTNLNNPSGTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPF 240

Query: 233 FHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHL 292
               D Y +   I + + + D                 ++   H R              
Sbjct: 241 ---GDKYSRESNIIRGIFSLD-----------------EMKCLHDRS------------- 267

Query: 293 VSPEALDFLDKLLRYDHQSRLTAREAMEHPYFY 325
           +  EA D + +++ +D   R TA + + HP F+
Sbjct: 268 LIAEATDLISQMIDHDPLKRPTAMKVLRHPLFW 300


>2PSQ-A nrPDB
          Length = 370

 Score = 45.1 bits (105), Expect = 6e-05,   Method: Compositional matrix adjust.
 Identities = 53/225 (23%), Positives = 103/225 (45%), Gaps = 47/225 (20%)

Query: 36  QDDYQLVRKLGRGKYSEVF--EAINITNNE-----KVVVKILKPVKKKK----IKREIKI 84
           +D   L + LG G + +V   EA+ I  ++      V VK+LK    +K    +  E+++
Sbjct: 80  RDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEM 139

Query: 85  LENLRGGPNIITL--ADIVKDPV------------------SRTPALVFEH-VNNTDFKQ 123
           ++ +    NII L  A     P+                   R P + + + +N    +Q
Sbjct: 140 MKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQ 199

Query: 124 LYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA---- 179
           +    T  D+    Y++ + ++Y  S   +HRD+   NV++  E+  +++ D+GLA    
Sbjct: 200 M----TFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLV-TENNVMKIADFGLARDIN 254

Query: 180 --EFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCML 222
             ++Y   +  N R+  ++   PE L D ++Y +  D+WS G ++
Sbjct: 255 NIDYYK--KTTNGRLPVKWM-APEALFD-RVYTHQSDVWSFGVLM 295


>4NEU-A nrPDB
          Length = 333

 Score = 44.7 bits (104), Expect = 7e-05,   Method: Compositional matrix adjust.
 Identities = 29/111 (26%), Positives = 55/111 (49%), Gaps = 16/111 (14%)

Query: 137 MYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH----PGQEYN--- 189
           + EI++ + Y H  G++H+D+KP N+++D++   +++ D GLA F        +E+N   
Sbjct: 128 ILEIIEGMCYLHGKGVIHKDLKPENILVDNDFH-IKIADLGLASFKMWSKLNNEEHNELR 186

Query: 190 -------VRVASRYFKGPELLVDYQMY-DYSLDMWSLGCMLASMIFRKEPF 232
                      + Y+  PE L D         D++S   +L ++   KEP+
Sbjct: 187 EVDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPY 237


>5WNL-A nrPDB
          Length = 342

 Score = 44.7 bits (104), Expect = 8e-05,   Method: Compositional matrix adjust.
 Identities = 40/203 (19%), Positives = 101/203 (49%), Gaps = 20/203 (9%)

Query: 44  KLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPN-----IITLA 98
           K+G G + +V++  ++     + +K   P      +  +++LE  +         I+ + 
Sbjct: 27  KVGSGGFGQVYKVRHVHWKTWLAIKC-SPSLHVDDRERMELLEEAKKMEMAKFRYILPVY 85

Query: 99  DIVKDPVSRTPALVFEHVNNTDFKQLYQTL-TDYDIRF-YMYEILKALDYCHSMG--IMH 154
            I ++PV     LV E++     ++L  +    +D+RF  ++E    +++ H M   ++H
Sbjct: 86  GICQEPV----GLVMEYMETGSLEKLLASEPLPWDLRFRIVHETAVGMNFLHCMSPPLLH 141

Query: 155 RDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY----FKGPELLVD-YQMY 209
            ++KP N+++D  H  +++ D+GLA+       +++ +   +    +  PE + +  +++
Sbjct: 142 LNLKPANILLD-AHYHVKISDFGLAKCNGMSHSHDLSMDGLFGTIAYLPPERIREKSRLF 200

Query: 210 DYSLDMWSLGCMLASMIFRKEPF 232
           D   D++S   ++  ++ +K+PF
Sbjct: 201 DTKHDVYSFAIVIWGVLTQKKPF 223


>5EG3-A nrPDB
          Length = 334

 Score = 44.7 bits (104), Expect = 8e-05,   Method: Compositional matrix adjust.
 Identities = 53/225 (23%), Positives = 101/225 (44%), Gaps = 47/225 (20%)

Query: 36  QDDYQLVRKLGRGKYSEVF--EAINITNNE-----KVVVKILKPVKKKK----IKREIKI 84
           +D   L + LG G + +V   EA+ I  ++      V VK+LK    +K    +  E+++
Sbjct: 34  RDKLTLGKPLGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEM 93

Query: 85  LENLRGGPNIITL--ADIVKDPV------------------SRTPALVFE-HVNNTDFKQ 123
           ++ +    NII L  A     P+                   R P +     +N    +Q
Sbjct: 94  MKMIGKHKNIINLLGACTQDGPLYVIVAYASKGNLREYLRARRPPGMELSPDINRVPEEQ 153

Query: 124 LYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA---- 179
           +    T  D+    Y++ + ++Y  S   +HRD+   NV++  E+  +++ D+GLA    
Sbjct: 154 M----TFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLV-TENNVMKIADFGLARDIN 208

Query: 180 --EFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCML 222
             +F+   +  N R+  ++   PE L D ++Y +  D+WS G ++
Sbjct: 209 NIDFFK--ETTNGRLPVKWM-APEALFD-RVYTHQSDVWSFGVLM 249


>5L2Q-C nrPDB
          Length = 320

 Score = 44.3 bits (103), Expect = 8e-05,   Method: Compositional matrix adjust.
 Identities = 23/107 (21%), Positives = 55/107 (51%), Gaps = 1/107 (0%)

Query: 128 LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE-FYHPGQ 186
           L++ +     Y++++ ++  H   I+HRD+K  N++++    ++ + ++ L +     G 
Sbjct: 150 LSERETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEGD 209

Query: 187 EYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFF 233
               +  S  +  P++L          DMW+LG +L +M++ + PF+
Sbjct: 210 LLKDQRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPFY 256


>4P5Q-A nrPDB
          Length = 361

 Score = 44.3 bits (103), Expect = 8e-05,   Method: Compositional matrix adjust.
 Identities = 50/208 (24%), Positives = 92/208 (44%), Gaps = 25/208 (12%)

Query: 45  LGRGKYSEVFEAINITNNEK---VVVKILKPVKKKKIKREIKILENLRGG---PNIITLA 98
           +G G++ EV        ++K   V +K LK    +K +R+     ++ G    PNII L 
Sbjct: 41  VGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIRLE 100

Query: 99  DIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYE-------ILKALDYCHSMG 151
            +V    S+   +V E++ N         L  +D +F + +       I   + Y   MG
Sbjct: 101 GVVTK--SKPVMIVTEYMENGSLDSF---LRKHDAQFTVIQLVGMLRGIASGMKYLSDMG 155

Query: 152 IMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH--PGQEYNVRVAS--RYFKGPELLVDYQ 207
            +HRD+   N++I + +   ++ D+GL+      P   Y  R       +  PE +  Y+
Sbjct: 156 YVHRDLAARNILI-NSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIA-YR 213

Query: 208 MYDYSLDMWSLGCML-ASMIFRKEPFFH 234
            +  + D+WS G +L   M + + P++ 
Sbjct: 214 KFTSASDVWSYGIVLWEVMSYGERPYWE 241


>4AT3-A nrPDB
          Length = 299

 Score = 44.3 bits (103), Expect = 1e-04,   Method: Compositional matrix adjust.
 Identities = 50/228 (21%), Positives = 102/228 (44%), Gaps = 37/228 (16%)

Query: 41  LVRKLGRGKYSEVF--EAINITNNEKVVVKILKPVK------KKKIKREIKILENLRGGP 92
           L R+LG G + +VF  E  N+   +  ++  +K +K      +K   RE ++L NL+   
Sbjct: 17  LKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQH-E 75

Query: 93  NIITLADIV--KDPVSRTPALVFEHVNNTDFKQLYQT----------------LTDYDIR 134
           +I+    +    DP+     +VFE++ + D  +  +                 LT   + 
Sbjct: 76  HIVKFYGVCVEGDPL----IMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQML 131

Query: 135 FYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVAS 194
               +I   + Y  S   +HRD+   N ++  E+  +++ D+G++   +    Y V   +
Sbjct: 132 HIAQQIAAGMVYLASQHFVHRDLATRNCLVG-ENLLVKIGDFGMSRDVYSTDYYRVGGHT 190

Query: 195 RY---FKGPELLVDYQMYDYSLDMWSLGCMLASMI-FRKEPFFHGHDN 238
                +  PE ++ Y+ +    D+WSLG +L  +  + K+P++   +N
Sbjct: 191 MLPIRWMPPESIM-YRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNN 237


>6DC0-A nrPDB
          Length = 292

 Score = 44.3 bits (103), Expect = 1e-04,   Method: Compositional matrix adjust.
 Identities = 68/288 (23%), Positives = 121/288 (42%), Gaps = 60/288 (20%)

Query: 53  VFEAINITNNEKVVVKILKPVK--KKKIKREIKILENLRGGPNIITLADIVKDPVSRTPA 110
           V  A+ I    ++  K+  P+K  + KI+  I++       P+   +  IV+  +  T A
Sbjct: 22  VSRALCIHTGRELRCKVF-PIKHYQDKIRPYIQL-------PSHSNITGIVEVILGETKA 73

Query: 111 LVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHE 167
            VF   +  D     ++   L + +      +I+ A+ +CH   I+  D+K    +   E
Sbjct: 74  YVFFEKDFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTE 133

Query: 168 HR-KLRLIDWGLAEFYHPGQEYNVRVASRY----FKGPELLVDYQMYD-YSLDMWSLGCM 221
            R +LRL      E  H  +  +  ++ ++    +  PE+L     Y   + D+WSLG M
Sbjct: 134 ERTQLRLESL---EDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVM 190

Query: 222 LASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRW 281
           L +++  + PF   HD+                           DP         S+ R 
Sbjct: 191 LYTLLVGRYPF---HDS---------------------------DPS-----ALFSKIRR 215

Query: 282 ERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 329
            +F   E+   +SP+A   +  LLR +   RLTA E + HP+F +V++
Sbjct: 216 GQFCIPEH---ISPKARCLIRSLLRREPSERLTAPEILLHPWFESVLE 260


>2VWV-A nrPDB
          Length = 302

 Score = 43.9 bits (102), Expect = 1e-04,   Method: Compositional matrix adjust.
 Identities = 67/324 (20%), Positives = 126/324 (38%), Gaps = 46/324 (14%)

Query: 25  DYESHVVEWGNQDDYQLVR---KLGRGKYSEVFEAINITNNEK---VVVKILKPVKKKKI 78
           D    V E+  + D   V+    +G G++ EV         +K   V +K LK    ++ 
Sbjct: 1   DPNEAVREFAKEIDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQ 60

Query: 79  KREIKILENLRGG---PNIITLADIVKDPVSRTPALVF-EHVNNTDFKQLYQ----TLTD 130
           +RE     ++ G    PNII L  +V + +   P ++  E + N       +      T 
Sbjct: 61  RREFLSEASIMGQFEHPNIIRLEGVVTNSM---PVMILTEFMENGALDSFLRLNDGQFTV 117

Query: 131 YDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNV 190
             +   +  I   + Y   M  +HRD+   N++++  +   ++ D+GL+ F         
Sbjct: 118 IQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNS-NLVCKVSDFGLSRFLEENSSDPT 176

Query: 191 RVASRYFK------GPELLVDYQMYDYSLDMWSLG-CMLASMIFRKEPFFHGHDNYDQLV 243
             +S   K       PE +  ++ +  + D WS G  M   M F + P++          
Sbjct: 177 ETSSLGGKIPIRWTAPEAIA-FRKFTSASDAWSYGIVMWEVMSFGERPYWD--------- 226

Query: 244 RIAKVLGTEDLYDYIDK-YNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLD 302
                +  +D+ + I++ Y +   P     L +     W++     N     P+ +  LD
Sbjct: 227 -----MSNQDVINAIEQDYRLPPPPDCPTSLHQLMLDCWQK---DRNARPRFPQVVSALD 278

Query: 303 KLLRYDHQSRLTARE--AMEHPYF 324
           K++R     ++ ARE     HP  
Sbjct: 279 KMIRNPASLKIVARENGGASHPLL 302


>5AR8-A nrPDB
          Length = 326

 Score = 43.5 bits (101), Expect = 1e-04,   Method: Compositional matrix adjust.
 Identities = 42/154 (27%), Positives = 78/154 (50%), Gaps = 18/154 (11%)

Query: 42  VRKLGRGKYSEVFEAINITNNEKVVVK---ILKPV---KKKKIKREIKILENLRGGPNII 95
           +R L RG    V  A +     +V VK   I  P+   ++K + RE +IL   R    I+
Sbjct: 37  LRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFS-YIL 95

Query: 96  TLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYD-----IRF-YMYEILKALDYCHS 149
            +  I  +P      +V E++ N    +L    T+Y      +RF  ++EI   ++Y H+
Sbjct: 96  PILGICNEP--EFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHN 153

Query: 150 MG--IMHRDVKPHNVMIDHEHRKLRLIDWGLAEF 181
           M   ++H D+K  N+++D+E   +++ D+GL+++
Sbjct: 154 MTPPLLHHDLKTQNILLDNEFH-VKIADFGLSKW 186


>3QUP-A nrPDB
          Length = 323

 Score = 43.5 bits (101), Expect = 1e-04,   Method: Compositional matrix adjust.
 Identities = 54/234 (23%), Positives = 94/234 (40%), Gaps = 37/234 (15%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGG---- 91
           +  + L R LG+G++  V EA  +   +   VK+   + K  I     I E LR      
Sbjct: 22  EQQFTLGRMLGKGEFGSVREA-QLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMK 80

Query: 92  ----PNIITLADI---------VKDPVSRTPA---------LVFEHVNNTDFKQLYQTLT 129
               P++  L  +         +  P+   P          L+   +    F    QTL 
Sbjct: 81  EFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTL- 139

Query: 130 DYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYN 189
              +RF M +I   ++Y  S   +HRD+   N M+  E   + + D+GL+   + G  Y 
Sbjct: 140 ---VRF-MVDIACGMEYLSSRNFIHRDLAARNCML-AEDMTVCVADFGLSRKIYSGDYYR 194

Query: 190 VRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYD 240
              AS+    +   E L D  +Y    D+W+ G  +  ++ R +  + G +N +
Sbjct: 195 QGCASKLPVKWLALESLAD-NLYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAE 247


>4CRS-A nrPDB
          Length = 341

 Score = 43.5 bits (101), Expect = 2e-04,   Method: Compositional matrix adjust.
 Identities = 74/308 (24%), Positives = 124/308 (40%), Gaps = 62/308 (20%)

Query: 35  NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNI 94
           N  D++    L RG + +V  A     NE   +K LK  K   + R+   +++L     I
Sbjct: 10  NLQDFRCCAVLLRGHFGKVLLAEYKNTNEMFAIKALK--KGDIVARD--EVDSLMCEKRI 65

Query: 95  ITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIR------------FYMYEILK 142
               + V+ P        F+   +  F   Y    D  +             FY   ++ 
Sbjct: 66  FETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTDVFSEPRAVFYAACVVL 125

Query: 143 ALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPE 201
            L Y H   I++RD+K  N+++D E   +++ D+GL  E    G   +    +  F  PE
Sbjct: 126 GLQYLHEHKIVYRDLKLDNLLLDTEGF-VKIADFGLCKEGMGYGDRTSTFCGTPEFLAPE 184

Query: 202 LLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKY 261
           +L +   Y  ++D W LG ++  M+  + P F G D              E+++D I   
Sbjct: 185 VLTETS-YTRAVDWWGLGVLIYEMLVGESP-FPGDDE-------------EEVFDSI--- 226

Query: 262 NIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTARE---- 317
                   ND +      R+ RF        +S EA+  + +LLR + + RL A E    
Sbjct: 227 -------VNDEV------RYPRF--------LSTEAISIMRRLLRRNPERRLGASEKDAE 265

Query: 318 -AMEHPYF 324
              +HP+F
Sbjct: 266 DVKKHPFF 273


>5U6B-A nrPDB
          Length = 307

 Score = 43.5 bits (101), Expect = 2e-04,   Method: Compositional matrix adjust.
 Identities = 55/244 (22%), Positives = 102/244 (41%), Gaps = 37/244 (15%)

Query: 41  LVRKLGRGKYSEVFEAINITNNE--KVVVKILKPVKKKKIKREIKILENLRGG----PNI 94
           L + LG G++  V E     ++   KV VK +K     + + E  + E +       PN+
Sbjct: 27  LGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNV 86

Query: 95  ITLADIVKDPVSR----TPALVFEHVNNTDFKQ--LYQTLTDYDIRF-------YMYEIL 141
           + L  +      R     P ++   + + D     LY  L D  +         +M +I 
Sbjct: 87  MRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIA 146

Query: 142 KALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEY-NVRVASRYFK-- 198
             ++Y  +   +HRD+   N M+ +E+  + + D+GL++  + G  Y   R+A    K  
Sbjct: 147 SGMEYLSTKRFIHRDLAARNCML-NENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWI 205

Query: 199 GPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYI 258
             E L D ++Y    D+WS G  +  +  R +  + G +N              ++YDY+
Sbjct: 206 AIESLAD-RVYTSKSDVWSFGVTMWEIATRGQTPYPGVEN-------------SEIYDYL 251

Query: 259 DKYN 262
            + N
Sbjct: 252 RQGN 255


>2WTK-B nrPDB
          Length = 373

 Score = 43.5 bits (101), Expect = 2e-04,   Method: Compositional matrix adjust.
 Identities = 33/115 (28%), Positives = 56/115 (48%), Gaps = 12/115 (10%)

Query: 128 LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHR--------KLRLIDWGLA 179
           + +  I + +  +LKALDY H MG +HR VK  +++I  + +         L +I  G  
Sbjct: 109 MNELAIAYILQGVLKALDYIHHMGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQR 168

Query: 180 E-FYHPGQEYNVRVASRYFKGPELL-VDYQMYDYSLDMWSLGCMLASMIFRKEPF 232
           +   H   +Y+V+V    +  PE+L  + Q YD   D++S+G     +     PF
Sbjct: 169 QRVVHDFPKYSVKVLP--WLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPF 221


>4LRM-A nrPDB
          Length = 334

 Score = 43.5 bits (101), Expect = 2e-04,   Method: Compositional matrix adjust.
 Identities = 46/223 (20%), Positives = 95/223 (42%), Gaps = 37/223 (16%)

Query: 35  NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKI--------LKPVKKKKIKREIKILE 86
            + +++ ++ LG G +  V++ + I   EKV + +          P   K+I  E  ++ 
Sbjct: 17  KETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMA 76

Query: 87  NLR--GGPNIITLADIVKD----------PVSRTPALVFEHVNNTDFKQLYQTLTDYDIR 134
           ++   G P++  L  I             P       V EH +N   + L          
Sbjct: 77  SVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLN-------- 128

Query: 135 FYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ-EYNV--- 190
            +  +I K ++Y     ++HRD+   NV++      +++ D+GLA+     + EY+    
Sbjct: 129 -WCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQH-VKITDFGLAKLLGAEEKEYHAEGG 186

Query: 191 RVASRYFKGPELLVDYQMYDYSLDMWSLGCMLAS-MIFRKEPF 232
           +V  ++     +L  +++Y +  D+WS G  +   M F  +P+
Sbjct: 187 KVPIKWMALESIL--HRIYTHQSDVWSYGVTVWELMTFGSKPY 227


>4Y83-A nrPDB
          Length = 332

 Score = 43.1 bits (100), Expect = 2e-04,   Method: Compositional matrix adjust.
 Identities = 46/187 (24%), Positives = 89/187 (47%), Gaps = 20/187 (10%)

Query: 47  RGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVS 106
           RG + +V+ A +I   +++  K++ PV + K   +++I    R   NI  L   V     
Sbjct: 83  RGAFGKVYLAQDIKTKKRMACKLI-PVDQFK-PSDVEIQACFRH-ENIAELYGAVL--WG 137

Query: 107 RTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVM 163
            T  L  E        +  ++   + +++I +    +LK LD+ HS  ++H D+KP N++
Sbjct: 138 ETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHHDIKPSNIV 197

Query: 164 IDHEHRKLRLIDWGLA-----EFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSL 218
                 K  L+D+GL+     + Y P    ++R  +  +  PE+++  + +    D++SL
Sbjct: 198 F--MSTKAVLVDFGLSVQMTEDVYFPK---DLR-GTEIYMSPEVIL-CRGHSTKADIYSL 250

Query: 219 GCMLASM 225
           G  L  M
Sbjct: 251 GATLIHM 257


>3KUL-B nrPDB
          Length = 325

 Score = 43.1 bits (100), Expect = 2e-04,   Method: Compositional matrix adjust.
 Identities = 40/186 (21%), Positives = 87/186 (46%), Gaps = 24/186 (12%)

Query: 65  VVVKILKPVKKKKIKREIKILENLRGG---PNIITLADIVKDPVSRTPALVFEHVNNTDF 121
           V +K LK    ++ +R+     ++ G    PNII L  +V     R   +V E++ N   
Sbjct: 80  VAIKALKAGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTR--GRLAMIVTEYMENGSL 137

Query: 122 KQLYQTLTDYDIRFYMYEIL-------KALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLI 174
               +T   +D +F + +++         + Y   +G +HRD+   NV++D  +   ++ 
Sbjct: 138 DTFLRT---HDGQFTIMQLVGMLRGVGAGMRYLSDLGYVHRDLAARNVLVD-SNLVCKVS 193

Query: 175 DWGLAEFYH--PGQEYNV---RVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMI-FR 228
           D+GL+      P   Y     ++  R+   PE +  ++ +  + D+WS G ++  ++ + 
Sbjct: 194 DFGLSRVLEDDPDAAYTTTGGKIPIRW-TAPEAIA-FRTFSSASDVWSFGVVMWEVLAYG 251

Query: 229 KEPFFH 234
           + P+++
Sbjct: 252 ERPYWN 257


>4XLV-A nrPDB
          Length = 328

 Score = 43.1 bits (100), Expect = 2e-04,   Method: Compositional matrix adjust.
 Identities = 63/281 (22%), Positives = 120/281 (42%), Gaps = 47/281 (16%)

Query: 32  EWG-NQDDYQLVRKLGRGKYSEVFE--AINITNNEKVVVKILKPVKKKKIKRE-IKILEN 87
           EW  +++   L+R+LG+G +  V+E  A +I   E      +K V +    RE I+ L  
Sbjct: 33  EWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNE 92

Query: 88  ---LRGGP--NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTL-------------T 129
              ++G    +++ L  +V     +   +V E + + D K   ++L             T
Sbjct: 93  ASVMKGFTCHHVVRLLGVVSK--GQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPT 150

Query: 130 DYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGL------AEFYH 183
             ++     EI   + Y ++   +HRD+   N M+ H+   +++ D+G+       ++Y 
Sbjct: 151 LQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDF-TVKIGDFGMTRDIYETDYYR 209

Query: 184 PGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLV 243
            G +  + V    +  PE L D  ++  S DMWS G +L  +    E  + G  N +Q++
Sbjct: 210 KGGKGLLPVR---WMAPESLKD-GVFTTSSDMWSFGVVLWEITSLAEQPYQGLSN-EQVL 264

Query: 244 RIAKVLG-----------TEDLYDYIDKYNIELDPRFNDIL 273
           +     G             DL     ++N  + P F +I+
Sbjct: 265 KFVMDGGYLDQPDNCPERVTDLMRMCWQFNPNMRPTFLEIV 305


>4XCU-A nrPDB
          Length = 300

 Score = 42.7 bits (99), Expect = 2e-04,   Method: Compositional matrix adjust.
 Identities = 27/89 (30%), Positives = 47/89 (52%), Gaps = 7/89 (7%)

Query: 138 YEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEY----NVRVA 193
           Y++ + + Y  S   +HRD+   NV++  E   +++ D+GLA   H    Y    N R+ 
Sbjct: 137 YQVARGMQYLESRKCIHRDLAARNVLVT-EDNVMKIADFGLARGVHHIDYYKKTSNGRLP 195

Query: 194 SRYFKGPELLVDYQMYDYSLDMWSLGCML 222
            ++   PE L D ++Y +  D+WS G +L
Sbjct: 196 VKWM-APEALFD-RVYTHQSDVWSFGILL 222


>3HNG-A nrPDB
          Length = 360

 Score = 42.7 bits (99), Expect = 3e-04,   Method: Compositional matrix adjust.
 Identities = 24/100 (24%), Positives = 54/100 (54%), Gaps = 5/100 (5%)

Query: 126 QTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPG 185
           + +T  D+  Y +++ + +++  S   +HRD+   N+++  E+  +++ D+GLA   +  
Sbjct: 194 EPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILL-SENNVVKICDFGLARDIYKN 252

Query: 186 QEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCML 222
            +Y  +  +R    +  PE + D ++Y    D+WS G +L
Sbjct: 253 PDYVRKGDTRLPLKWMAPESIFD-KIYSTKSDVWSYGVLL 291


>2R2P-A nrPDB
          Length = 295

 Score = 42.4 bits (98), Expect = 4e-04,   Method: Compositional matrix adjust.
 Identities = 53/234 (22%), Positives = 104/234 (44%), Gaps = 24/234 (10%)

Query: 20  PREYWDYESHVVEWGNQDDYQLV---RKLGRGKYSEVFEA-INITNNEK--VVVKILKPV 73
           P  Y D    V E+  + +   +   R +G G++ EV    + +    +  V +K LK  
Sbjct: 2   PHTYEDPNQAVHEFAKEIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVG 61

Query: 74  KKKKIKREIKILENLRGG---PNIITLADIVKDPVSRTPALVFEHVNN----TDFKQLYQ 126
             +K +R+     ++ G    PNII L  +V    S+   +V E++ N    T  K+   
Sbjct: 62  YTEKQRRDFLGEASIMGQFDHPNIIHLEGVVTK--SKPVMIVTEYMENGSLDTFLKKNDG 119

Query: 127 TLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH--P 184
             T   +   +  I   + Y   MG +HRD+   N++I+  +   ++ D+GL+      P
Sbjct: 120 QFTVIQLVGMLRGISAGMKYLSDMGYVHRDLAARNILINS-NLVCKVSDFGLSRVLEDDP 178

Query: 185 GQEYNVR---VASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMI-FRKEPFFH 234
              Y  R   +  R+   PE +  ++ +  + D+WS G ++  ++ + + P++ 
Sbjct: 179 EAAYTTRGGKIPIRW-TAPEAIA-FRKFTSASDVWSYGIVMWEVVSYGERPYWE 230


>5X18-A nrPDB
          Length = 295

 Score = 42.0 bits (97), Expect = 4e-04,   Method: Compositional matrix adjust.
 Identities = 34/151 (22%), Positives = 72/151 (47%), Gaps = 8/151 (5%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK--KIKREIKILENLRGGPNIIT 96
           Y++ +K+G G +  +FE  N+ N   V +K  +P K +  +++ E K  + L G PNI  
Sbjct: 9   YKIGKKIGEGSFGVLFEGTNMINGVPVAIK-FEPRKTEAPQLRDEYKTYKILNGTPNIPY 67

Query: 97  LADIVKDPVSRTPALVFEHVNNTD-FKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHR 155
                ++ +     +     +  D F    +  +   +     +++  ++  H+  +++R
Sbjct: 68  AYYFGQEGLHNILVIDLLGPSLEDLFDWCGRKFSVKTVVQVAVQMITLIEDLHAHDLIYR 127

Query: 156 DVKPHNVMIDH----EHRKLRLIDWGLAEFY 182
           D+KP N +I      +   + LID+G+A+ Y
Sbjct: 128 DIKPDNFLIGRPGQPDANNIHLIDFGMAKQY 158


>1FVR-A nrPDB
          Length = 327

 Score = 42.0 bits (97), Expect = 5e-04,   Method: Compositional matrix adjust.
 Identities = 50/225 (22%), Positives = 95/225 (42%), Gaps = 38/225 (16%)

Query: 30  VVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKV--VVKILKPVKKKKIKR----EIK 83
           V++W   +D +    +G G + +V +A    +  ++   +K +K    K   R    E++
Sbjct: 21  VLDW---NDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELE 77

Query: 84  ILENLRGGPNIITLADIVKDPVSRTPALVFE-HVNNTDF----------------KQLYQ 126
           +L  L   PNII L    +       A+ +  H N  DF                     
Sbjct: 78  VLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTAS 137

Query: 127 TLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ 186
           TL+   +  +  ++ + +DY      +HRD+   N+++  E+   ++ D+GL+     GQ
Sbjct: 138 TLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVG-ENYVAKIADFGLSR----GQ 192

Query: 187 EYNV-----RVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMI 226
           E  V     R+  R+     L  +Y +Y  + D+WS G +L  ++
Sbjct: 193 EVYVKKTMGRLPVRWMAIESL--NYSVYTTNSDVWSYGVLLWEIV 235


>3VHK-A nrPDB
          Length = 368

 Score = 41.6 bits (96), Expect = 6e-04,   Method: Compositional matrix adjust.
 Identities = 23/90 (25%), Positives = 48/90 (53%), Gaps = 5/90 (5%)

Query: 136 YMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASR 195
           Y +++ K +++  S   +HRD+   N+++  E   +++ D+GLA   +   +Y  +  +R
Sbjct: 205 YSFQVAKGMEFLASRKCIHRDLAARNILLS-EKNVVKICDFGLARDIYKDPDYVRKGDAR 263

Query: 196 Y---FKGPELLVDYQMYDYSLDMWSLGCML 222
               +  PE + D ++Y    D+WS G +L
Sbjct: 264 LPLKWMAPETIFD-RVYTIQSDVWSFGVLL 292


>3QD2-B nrPDB
          Length = 332

 Score = 41.6 bits (96), Expect = 6e-04,   Method: Compositional matrix adjust.
 Identities = 25/102 (24%), Positives = 53/102 (51%), Gaps = 15/102 (14%)

Query: 139 EILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE----------- 187
           +I +A+++ HS G+MHRD+KP N+    +   +++ D+GL       +E           
Sbjct: 172 QIAEAVEFLHSKGLMHRDLKPSNIFFTMDD-VVKVGDFGLVTAMDQDEEEQTVLTPMPAY 230

Query: 188 --YNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIF 227
             +  +V ++ +  PE  +    Y + +D++SLG +L  +++
Sbjct: 231 ATHTGQVGTKLYMSPE-QIHGNNYSHKVDIFSLGLILFELLY 271



 Score = 32.3 bits (72), Expect = 0.34,   Method: Compositional matrix adjust.
 Identities = 16/55 (29%), Positives = 32/55 (58%), Gaps = 4/55 (7%)

Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL----KPVKKKKIKREIKILENL 88
          D++ ++ +GRG +  VFEA N  ++    +K +    + + ++K+ RE+K L  L
Sbjct: 7  DFEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKL 61


>4XHH-A nrPDB
          Length = 403

 Score = 41.2 bits (95), Expect = 7e-04,   Method: Compositional matrix adjust.
 Identities = 30/151 (19%), Positives = 75/151 (49%), Gaps = 10/151 (6%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK--KIKREIKILENLRGGPNIIT 96
           +++ RK+G G + +++   N+ + E+V ++ L+ ++ +  ++  E ++ + L GG  I  
Sbjct: 9   FRIGRKIGSGSFGDIYHGTNLISGEEVAIR-LESIRSRHPQLDYESRVYKYLSGGVGIPF 67

Query: 97  LADIVKDPVSRTPALVFEHVN---NTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIM 153
           +    ++      A+V + +       F   ++  +   +     +++  + Y H    +
Sbjct: 68  IRWFGRE--GEYNAMVIDLLGPSLEDLFNYCHRKFSFKTVIMLALQMICRVQYIHGRSFI 125

Query: 154 HRDVKPHNVMIDHEHR--KLRLIDWGLAEFY 182
           HRD+KP N ++    R   + +ID+GL++ Y
Sbjct: 126 HRDIKPDNFLMGVGRRGSTVHVIDFGLSKKY 156


>3BBT-B nrPDB
          Length = 328

 Score = 41.2 bits (95), Expect = 8e-04,   Method: Compositional matrix adjust.
 Identities = 61/296 (20%), Positives = 120/296 (40%), Gaps = 26/296 (8%)

Query: 35  NQDDYQLVRKLGRGKYSEVFEAINITNNEKV----VVKILKPVKKKKIKREI---KILEN 87
            + + + V+ LG G +  V++ I +   E V     +KIL      K   E     ++  
Sbjct: 13  KETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMA 72

Query: 88  LRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRF-YMYEILKALDY 146
               P+++ L  +   P  +    +  H    ++   ++      +   +  +I K + Y
Sbjct: 73  SMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMY 132

Query: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ-EYNVRVASRYFKGPEL-LV 204
                ++HRD+   NV++   +  +++ D+GLA      + EYN        K   L  +
Sbjct: 133 LEERRLVHRDLAARNVLVKSPNH-VKITDFGLARLLEGDEKEYNADGGKMPIKWMALECI 191

Query: 205 DYQMYDYSLDMWSLGCMLAS-MIFRKEPF--FHGHDNYDQLVRIAKV----LGTEDLYDY 257
            Y+ + +  D+WS G  +   M F  +P+      +  D L +  ++    + T D+Y  
Sbjct: 192 HYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMV 251

Query: 258 IDK-YNIELD--PRFNDILGRHSR-----KRWERFVHSENQHLVSPEALDFLDKLL 305
           + K + I+ D  P+F ++    SR     +R+      +   L SP    F   LL
Sbjct: 252 MVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLL 307


>2QLU-A nrPDB
          Length = 314

 Score = 41.2 bits (95), Expect = 8e-04,   Method: Compositional matrix adjust.
 Identities = 51/213 (23%), Positives = 98/213 (46%), Gaps = 28/213 (13%)

Query: 40  QLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKIL-------ENL---- 88
           QL+    RG++  V++A  +  N+ V VKI     K+  + E +I        ENL    
Sbjct: 18  QLLEIKARGRFGCVWKAQLM--NDFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQFI 75

Query: 89  ---RGGPNI---ITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILK 142
              + G N+   + L     D  S T  L    +   +   + +T++   + +   ++  
Sbjct: 76  AAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMS-RGLSYLHEDVPW 134

Query: 143 ALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ---EYNVRVASRYFKG 199
                H   I HRD K  NV++  +   + L D+GLA  + PG+   + + +V +R +  
Sbjct: 135 CRGEGHKPSIAHRDFKSKNVLLKSDLTAV-LADFGLAVRFEPGKPPGDTHGQVGTRRYMA 193

Query: 200 PELL---VDYQMYDY-SLDMWSLGCMLASMIFR 228
           PE+L   +++Q   +  +DM+++G +L  ++ R
Sbjct: 194 PEVLEGAINFQRDAFLRIDMYAMGLVLWELVSR 226


>3ZZW-A nrPDB
          Length = 289

 Score = 40.8 bits (94), Expect = 0.001,   Method: Compositional matrix adjust.
 Identities = 60/283 (21%), Positives = 117/283 (41%), Gaps = 51/283 (18%)

Query: 40  QLVRKLGRGKYSEVFEAINI-----TNNEKVVVKILKPVKKKKIKREIKILENLRG---G 91
           + + +LG  ++ +V++            + V +K LK   +  ++ E +    LR     
Sbjct: 12  RFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRARLQH 71

Query: 92  PNIITLADIV-KD-PVSRTPALVFEHVNNTDFKQLY-------------------QTLTD 130
           PN++ L  +V KD P+S    ++F + ++ D  +                       L  
Sbjct: 72  PNVVCLLGVVTKDQPLS----MIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEP 127

Query: 131 YDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNV 190
            D    + +I   ++Y  S  ++H+D+   NV++ ++   +++ D GL    +    Y +
Sbjct: 128 PDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLV-YDKLNVKISDLGLFREVYAADYYKL 186

Query: 191 RVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYD--QLVRI 245
              S     +  PE ++ Y  +    D+WS G +L  +       + G+ N D  +++R 
Sbjct: 187 LGNSLLPIRWMAPEAIM-YGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRN 245

Query: 246 AKVLGT-EDLYDYIDKYNIEL-------DPRFNDILGRHSRKR 280
            +VL   +D   ++    IE         PRF DI   HSR R
Sbjct: 246 RQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKDI---HSRLR 285


>4XHL-A nrPDB
          Length = 394

 Score = 40.8 bits (94), Expect = 0.001,   Method: Compositional matrix adjust.
 Identities = 30/151 (19%), Positives = 73/151 (48%), Gaps = 10/151 (6%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK--KIKREIKILENLRGGPNIIT 96
           +++ RK+G G + +++   N+ + E+V ++ L+ ++ +  ++  E ++   L GG  I  
Sbjct: 9   FRIGRKIGSGSFGDIYHGTNLISGEEVAIR-LESIRSRHPQLDYESRVYRYLSGGVGIPF 67

Query: 97  LADIVKDPVSRTPALVFEHVN---NTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIM 153
           +    ++      A+V + +       F   ++  +   +     ++   + Y H    +
Sbjct: 68  IRWFGRE--GEYNAMVIDLLGPSLEDLFNYCHRRFSFKTVIMLALQMFCRIQYIHGRSFI 125

Query: 154 HRDVKPHNVMIDHEHR--KLRLIDWGLAEFY 182
           HRD+KP N ++    R   + +ID+GL++ Y
Sbjct: 126 HRDIKPDNFLMGVGRRGSTVHVIDFGLSKKY 156


>3LZB-A nrPDB
          Length = 327

 Score = 40.4 bits (93), Expect = 0.001,   Method: Compositional matrix adjust.
 Identities = 45/221 (20%), Positives = 94/221 (42%), Gaps = 36/221 (16%)

Query: 35  NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKI--------LKPVKKKKIKREIKILE 86
            + +++ ++ LG G +  V++ + I   EKV + +          P   K+I  E  ++ 
Sbjct: 13  KETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMA 72

Query: 87  NLRGGPNIITLADIVKD----------PVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFY 136
           ++   P++  L  I             P       V EH +N   + L           +
Sbjct: 73  SV-DNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLN---------W 122

Query: 137 MYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ-EYNV---RV 192
             +I K ++Y     ++HRD+   NV++      +++ D+GLA+     + EY+    +V
Sbjct: 123 CVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQH-VKITDFGLAKLLGAEEKEYHAEGGKV 181

Query: 193 ASRYFKGPELLVDYQMYDYSLDMWSLGCMLAS-MIFRKEPF 232
             ++     +L  +++Y +  D+WS G  +   M F  +P+
Sbjct: 182 PIKWMALESIL--HRIYTHQSDVWSYGVTVWELMTFGSKPY 220


>4IX6-A nrPDB
          Length = 350

 Score = 40.4 bits (93), Expect = 0.001,   Method: Compositional matrix adjust.
 Identities = 20/49 (40%), Positives = 29/49 (59%), Gaps = 1/49 (2%)

Query: 137 MYEILKALDYCHSMGIMHRDVKPHNVM-IDHEHRKLRLIDWGLAEFYHP 184
           M E+L +L   H  G++HRDVKP N++  + +   L+LID G A    P
Sbjct: 149 MRELLGSLARLHECGVVHRDVKPANLIAAEKDGGVLKLIDLGAAALCLP 197


>5GNK-A nrPDB
          Length = 297

 Score = 40.4 bits (93), Expect = 0.001,   Method: Compositional matrix adjust.
 Identities = 45/221 (20%), Positives = 94/221 (42%), Gaps = 36/221 (16%)

Query: 35  NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKI--------LKPVKKKKIKREIKILE 86
            + +++ ++ LG G +  V++ + I   EKV + +          P   K+I  E  ++ 
Sbjct: 17  KETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMA 76

Query: 87  NLRGGPNIITLADIVKD----------PVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFY 136
           ++   P++  L  I             P       V EH +N   + L           +
Sbjct: 77  SV-DNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLN---------W 126

Query: 137 MYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ-EYNV---RV 192
             +I K ++Y     ++HRD+   NV++      +++ D+GLA+     + EY+    +V
Sbjct: 127 CVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQH-VKITDFGLAKLLGAEEKEYHAEGGKV 185

Query: 193 ASRYFKGPELLVDYQMYDYSLDMWSLGCMLAS-MIFRKEPF 232
             ++     +L  +++Y +  D+WS G  +   M F  +P+
Sbjct: 186 PIKWMALESIL--HRIYTHQSDVWSYGVTVWELMTFGSKPY 224


>4CI6-B nrPDB
          Length = 643

 Score = 39.7 bits (91), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 23/72 (31%), Positives = 35/72 (48%), Gaps = 4/72 (5%)

Query: 133 IRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRV 192
           I+F  + +L   ++    GI+H D+KP NV+ D    +  +ID GL    H       + 
Sbjct: 158 IKFIAHRLLDVTNHLAKAGIVHNDIKPGNVVFDRASGEPVVIDLGL----HSRSGEQPKG 213

Query: 193 ASRYFKGPELLV 204
            +  FK PEL V
Sbjct: 214 FTESFKAPELGV 225


>3DKO-A nrPDB
          Length = 318

 Score = 39.7 bits (91), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 51/236 (21%), Positives = 100/236 (42%), Gaps = 30/236 (12%)

Query: 20  PREYWDYESHVVEWGNQDDYQLV---RKLGRGKYSEVFEA---INITNNEKVVVKILKPV 73
           P  Y D    V ++  + D   +   R +G G++ EV      +    +  V +K LK  
Sbjct: 23  PETYEDPNRAVHQFAKELDASCIKIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVG 82

Query: 74  KKKKIKREIKILENLRGG---PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTD 130
             +K +R+     ++ G    PN++ L  +V     +   +V E + N         L  
Sbjct: 83  YTEKQRRDFLCEASIMGQFDHPNVVHLEGVVTR--GKPVMIVIEFMENGALDAF---LRK 137

Query: 131 YDIRFYMYE-------ILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH 183
           +D +F + +       I   + Y   MG +HRD+   N++++  +   ++ D+GL+    
Sbjct: 138 HDGQFTVIQLVGMLRGIAAGMRYLADMGYVHRDLAARNILVN-SNLVCKVSDFGLSRVIE 196

Query: 184 --PGQEYNV---RVASRYFKGPELLVDYQMYDYSLDMWSLG-CMLASMIFRKEPFF 233
             P   Y     ++  R+   PE  + Y+ +  + D+WS G  M   M + + P++
Sbjct: 197 DDPEAVYTTTGGKIPVRW-TAPE-AIQYRKFTSASDVWSYGIVMWEVMSYGERPYW 250


>1JPA-A nrPDB
          Length = 312

 Score = 39.3 bits (90), Expect = 0.003,   Method: Compositional matrix adjust.
 Identities = 49/235 (20%), Positives = 97/235 (41%), Gaps = 26/235 (11%)

Query: 20  PREYWDYESHVVEWGNQDDYQLVR---KLGRGKYSEVFEA-INITNNEK--VVVKILKPV 73
           P  + D    V E+  + D   V+    +G G++ EV    + +    +  V +K LK  
Sbjct: 13  PFTFEDPNEAVREFAKEIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSG 72

Query: 74  KKKKIKREIKILENLRGG---PNIITLADIVKDPVSRTPALVF-EHVNNTDFKQLYQT-- 127
             +K +R+     ++ G    PN+I L  +V      TP ++  E + N       +   
Sbjct: 73  YTEKQRRDFLSEASIMGQFDHPNVIHLEGVV---TKSTPVMIITEFMENGSLDSFLRQND 129

Query: 128 --LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPG 185
              T   +   +  I   + Y   M  +HRD+   N++++  +   ++ D+GL+ F    
Sbjct: 130 GQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVN-SNLVCKVSDFGLSRFLEDD 188

Query: 186 QE---YNVRVASRY---FKGPELLVDYQMYDYSLDMWSLG-CMLASMIFRKEPFF 233
                Y   +  +    +  PE  + Y+ +  + D+WS G  M   M + + P++
Sbjct: 189 TSDPTYTSALGGKIPIRWTAPE-AIQYRKFTSASDVWSYGIVMWEVMSYGERPYW 242


>4JRN-A nrPDB
          Length = 372

 Score = 39.3 bits (90), Expect = 0.003,   Method: Compositional matrix adjust.
 Identities = 49/237 (20%), Positives = 87/237 (36%), Gaps = 62/237 (26%)

Query: 45  LGRGKYSEVFEAINITNNEKVVVKILKPVKKKK------IKREIKILENL---------- 88
           LG G ++ V+EA ++  NE++ VK+    K+        ++RE     N           
Sbjct: 76  LGSGGFATVYEATDVETNEELAVKVFMSEKEPTDETMLDLQRESSCYRNFSLAKTAKDAQ 135

Query: 89  -----------------------------RGGPNIITLADIVKDPVSRTPALVF--EHVN 117
                                        R  PN   L    +  +S+  + VF    VN
Sbjct: 136 ESCRFMVPSDVVMLEGQPASTEVVIGLTTRWVPNYFLLMMRAEADMSKVISWVFGDASVN 195

Query: 118 NTDFKQLYQTLTDYDIRFYMY-EILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDW 176
            ++F  +        +R Y+  + +K +    + GI+H D+KP N ++  + R L L D+
Sbjct: 196 KSEFGLV--------VRMYLSSQAIKLVANVQAQGIVHTDIKPANFLLLKDGR-LFLGDF 246

Query: 177 GLAEFYHPGQEYNVRVASRYFKGPE--LLVDYQMYDYSLDMWSLGCMLASMIFRKEP 231
           G    Y         + +  ++ PE         Y +  D W LG  L  +  ++ P
Sbjct: 247 GT---YRINNSVGRAIGTPGYEPPERPFQATGITYTFPTDAWQLGITLYCIWCKERP 300


>4YFF-A nrPDB
          Length = 311

 Score = 39.3 bits (90), Expect = 0.003,   Method: Compositional matrix adjust.
 Identities = 37/163 (22%), Positives = 74/163 (45%), Gaps = 11/163 (6%)

Query: 80  REIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTD-FKQLYQTLTDYDIR---F 135
           RE+ IL  L     I  +   + DP     A+V ++++    F  L++     D++    
Sbjct: 89  REVSILCQLNHPCVIQFVGACLNDPSQF--AIVTQYISGGSLFSLLHEQKRILDLQSKLI 146

Query: 136 YMYEILKALDYCHSMG--IMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNV--R 191
              ++ K ++Y H++   I+HRD+  HN+++ +E     + D+G + F     E N+  +
Sbjct: 147 IAVDVAKGMEYLHNLTQPIIHRDLNSHNILL-YEDGHAVVADFGESRFLQSLDEDNMTKQ 205

Query: 192 VASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFH 234
             +  +  PE+      Y    D++S    L  ++  + PF H
Sbjct: 206 PGNLRWMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPFAH 248


>5DMZ-A nrPDB
          Length = 365

 Score = 39.3 bits (90), Expect = 0.003,   Method: Compositional matrix adjust.
 Identities = 47/213 (22%), Positives = 88/213 (41%), Gaps = 35/213 (16%)

Query: 45  LGRGKYSEVFEAI-----NITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLAD 99
           LG G +++V+EA      +  N +K V+K+ KP    +     +++E L+     + +  
Sbjct: 73  LGEGAFAQVYEATQGDLNDAKNKQKFVLKVQKPANPWEFYIGTQLMERLKPSMQHMFMKF 132

Query: 100 IVKDPVSRTPALVFEHVN------------NTDFKQLYQTLTDYDIRFYMYEILKALDYC 147
                      LV E  +            NT  K + Q L    I F M  +L  ++  
Sbjct: 133 YSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEKVMPQGLV---ISFAM-RMLYMIEQV 188

Query: 148 HSMGIMHRDVKPHNVMI----------DHEHRKLRLIDWGLA---EFYHPGQEYNVRVAS 194
           H   I+H D+KP N ++          D     L LID G +   + +  G  +  +  +
Sbjct: 189 HDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMKLFPKGTIFTAKCET 248

Query: 195 RYFKGPELLVDYQMYDYSLDMWSLGCMLASMIF 227
             F+  E+L + + ++Y +D + +   +  M+F
Sbjct: 249 SGFQCVEMLSN-KPWNYQIDYFGVAATVYCMLF 280


>3V5Q-A nrPDB
          Length = 297

 Score = 39.3 bits (90), Expect = 0.003,   Method: Compositional matrix adjust.
 Identities = 52/229 (22%), Positives = 97/229 (42%), Gaps = 38/229 (16%)

Query: 38  DYQLVRKLGRGKYSEVF--EAINITNNEK---VVVKILKP---VKKKKIKREIKILENLR 89
           D  L R+LG G + +VF  E  N++  +    V VK LK      +K  +RE ++L NL+
Sbjct: 16  DIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQ 75

Query: 90  GGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT-------LTDYDIR-------- 134
              +I+    +  D       +VFE++ + D  +  +        L D   R        
Sbjct: 76  -HEHIVKFYGVCGD--GDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGL 132

Query: 135 ----FYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNV 190
                   +I   + Y  S   +HRD+   N ++   +  +++ D+G++   +    Y V
Sbjct: 133 SQMLHIASQIASGMVYLASQHFVHRDLATRNCLVG-ANLLVKIGDFGMSRDVYSTDYYRV 191

Query: 191 ----RVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMI-FRKEPFFH 234
                +  R+   P   + Y+ +    D+WS G +L  +  + K+P+F 
Sbjct: 192 GGHTMLPIRWM--PPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQ 238


>5VO2-A nrPDB
          Length = 300

 Score = 38.9 bits (89), Expect = 0.003,   Method: Compositional matrix adjust.
 Identities = 45/207 (21%), Positives = 90/207 (43%), Gaps = 46/207 (22%)

Query: 45  LGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDP 104
           +G G    VF  +   + E+V VK ++ +K+  IK     L  L+  PNIIT     K  
Sbjct: 20  VGSGAQGAVF--LGRFHGEEVAVKKVRDLKETDIKH----LRKLKH-PNIITF----KGV 68

Query: 105 VSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKA-------------------LD 145
            ++ P               Y  L ++  +  +YE+L+A                   ++
Sbjct: 69  CTQAPC--------------YCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMN 114

Query: 146 YCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVD 205
           Y H   I+HRD+K  N++I ++   +++ D+G ++             +  +  PE++ +
Sbjct: 115 YLHLHKIIHRDLKSPNMLITYDDV-VKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRN 173

Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPF 232
             + +  +D+WS G +L  ++  + P+
Sbjct: 174 EPVSE-KVDIWSFGVVLWELLTGEIPY 199


>4XI2-A nrPDB
          Length = 446

 Score = 38.9 bits (89), Expect = 0.004,   Method: Compositional matrix adjust.
 Identities = 22/87 (25%), Positives = 48/87 (55%), Gaps = 6/87 (6%)

Query: 139 EILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY-- 196
           ++ +A++Y  S   +HRD+   N +++ +   +++ D+GL+  Y    EY   V S++  
Sbjct: 291 DVCEAMEYLESKQFLHRDLAARNCLVN-DQGVVKVSDFGLSR-YVLDDEYTSSVGSKFPV 348

Query: 197 -FKGPELLVDYQMYDYSLDMWSLGCML 222
            +  PE+L+ Y  +    D+W+ G ++
Sbjct: 349 RWSPPEVLM-YSKFSSKSDIWAFGVLM 374


>6E4F-A nrPDB
          Length = 290

 Score = 38.9 bits (89), Expect = 0.004,   Method: Compositional matrix adjust.
 Identities = 43/197 (21%), Positives = 91/197 (46%), Gaps = 22/197 (11%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK--PVKKKKIKREIKILENLRGGPNII 95
           D   +++LG G++  V +         V +K++K   + + +   E K++ NL     ++
Sbjct: 32  DLTFLKELGTGQFG-VVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNL-SHEKLV 89

Query: 96  TLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILK-------ALDYCH 148
            L  +      R   ++ E++ N     L   L +   RF   ++L+       A++Y  
Sbjct: 90  QLYGVCTK--QRPIFIITEYMANG---CLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLE 144

Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLVD 205
           S   +HRD+   N +++ +   +++ D+GL+  Y    EY   V S++   +  PE+L+ 
Sbjct: 145 SKQFLHRDLAARNCLVN-DQGVVKVSDFGLSR-YVLDDEYTSSVGSKFPVRWSPPEVLM- 201

Query: 206 YQMYDYSLDMWSLGCML 222
           Y  +    D+W+ G ++
Sbjct: 202 YSKFSSKSDIWAFGVLM 218


>5MJB-A nrPDB
          Length = 305

 Score = 38.9 bits (89), Expect = 0.004,   Method: Compositional matrix adjust.
 Identities = 48/229 (20%), Positives = 96/229 (41%), Gaps = 24/229 (10%)

Query: 25  DYESHVVEWGNQDDYQLVR---KLGRGKYSEVFEA-INITNNEK--VVVKILKPVKKKKI 78
           D    V E+  + D   V+    +G G++ EV++  + +    +  V +K LK    +K 
Sbjct: 11  DPNEAVREFAKEIDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQ 70

Query: 79  KREIKILENLRGG---PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----LTDY 131
           +R+     ++ G     NII L  +V    SR   ++ E + N       +      T  
Sbjct: 71  RRDFLSEASIMGQFDHRNIIRLEGVVTK--SRPVMIITEFMENCALDSFLRQNDGQFTVI 128

Query: 132 DIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE---Y 188
            +   +  I   + Y   M  +HRD+   N+++ + +   ++ D+GL+ +         Y
Sbjct: 129 QLVGMLRGIAAGMKYLSEMNYVHRDLAARNILV-NSNLVCKVSDFGLSRYLQDDTSDPTY 187

Query: 189 NVRVASRY---FKGPELLVDYQMYDYSLDMWSLG-CMLASMIFRKEPFF 233
              +  +    +  PE +  Y+ +  + D+WS G  M   M F + P++
Sbjct: 188 TSSLGGKIPVRWTAPEAIA-YRKFTSASDVWSYGIVMWEVMSFGERPYW 235


>3SOC-A nrPDB
          Length = 322

 Score = 38.5 bits (88), Expect = 0.005,   Method: Compositional matrix adjust.
 Identities = 27/100 (27%), Positives = 54/100 (54%), Gaps = 8/100 (8%)

Query: 136 YMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ---EYNVRV 192
           Y++E +  L   H   I HRD+K  NV++ +      + D+GLA  +  G+   + + +V
Sbjct: 136 YLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTAC-IADFGLALKFEAGKSAGDTHGQV 194

Query: 193 ASRYFKGPELL---VDYQMYDY-SLDMWSLGCMLASMIFR 228
            +R +  PE+L   +++Q   +  +DM+++G +L  +  R
Sbjct: 195 GTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASR 234


>1LUF-A nrPDB
          Length = 343

 Score = 38.5 bits (88), Expect = 0.006,   Method: Compositional matrix adjust.
 Identities = 47/260 (18%), Positives = 102/260 (39%), Gaps = 48/260 (18%)

Query: 36  QDDYQLVRKLGRGKYSEVFEA-----INITNNEKVVVKILKPVK----KKKIKREIKILE 86
           +++ + VR +G G +  VF+A     +       V VK+LK       +   +RE  ++ 
Sbjct: 46  RNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMA 105

Query: 87  NLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMY-------- 138
                PNI+ L  +    V +   L+FE++   D  +  ++++ + +    +        
Sbjct: 106 EF-DNPNIVKLLGVCA--VGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRAR 162

Query: 139 -------------------EILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA 179
                              ++   + Y      +HRD+   N ++  E+  +++ D+GL+
Sbjct: 163 VSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVG-ENMVVKIADFGLS 221

Query: 180 EFYHPGQEY----NVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMI-FRKEPFF- 233
              +    Y    N  +  R+   P   + Y  Y    D+W+ G +L  +  +  +P++ 
Sbjct: 222 RNIYSADYYKADGNDAIPIRWM--PPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYG 279

Query: 234 HGHDNYDQLVRIAKVLGTED 253
             H+     VR   +L   +
Sbjct: 280 MAHEEVIYYVRDGNILACPE 299


>4Y93-A nrPDB
          Length = 446

 Score = 37.4 bits (85), Expect = 0.011,   Method: Compositional matrix adjust.
 Identities = 41/197 (20%), Positives = 89/197 (45%), Gaps = 22/197 (11%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK--PVKKKKIKREIKILENLRGGPNII 95
           D   +++LG G++  V +         V +K++K   + + +   E K++ NL     ++
Sbjct: 189 DLTFLKELGTGQFG-VVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNL-SHEKLV 246

Query: 96  TLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILK-------ALDYCH 148
            L  +      R   ++ E++ N     L   L +   RF   ++L+       A++Y  
Sbjct: 247 QLYGVCTK--QRPIFIITEYMANGC---LLNYLREMRHRFQTQQLLEMCKDVCEAMEYLE 301

Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLVD 205
           S   +HRD+   N +++ +   +++ D+G+   Y    EY     S++   +  PE+L+ 
Sbjct: 302 SKQFLHRDLAARNCLVN-DQGVVKVSDFGMTR-YVLDDEYTSSTGSKFPVKWASPEVLM- 358

Query: 206 YQMYDYSLDMWSLGCML 222
           Y  +    D+W+ G ++
Sbjct: 359 YSKFSSKSDIWAFGVLM 375


>5U6C-A nrPDB
          Length = 315

 Score = 37.0 bits (84), Expect = 0.014,   Method: Compositional matrix adjust.
 Identities = 53/242 (21%), Positives = 97/242 (40%), Gaps = 29/242 (11%)

Query: 41  LVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGG--------P 92
           L + LG G++  V E  N+   +   +K+     K     + +I E L           P
Sbjct: 40  LGKILGEGEFGSVMEG-NLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHP 98

Query: 93  NIITLADIVKDPVSR---TPALVFEHVNNTDFKQ--LYQTLTD-------YDIRFYMYEI 140
           N++ L  +  +  S+    P ++   +   D     LY  L           +  +M +I
Sbjct: 99  NVMRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDI 158

Query: 141 LKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEY-NVRVASRYFK- 198
              ++Y  +   +HRD+   N M+  +   + + D+GL++  + G  Y   R+A    K 
Sbjct: 159 ALGMEYLSNRNFLHRDLAARNCML-RDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKW 217

Query: 199 -GPELLVDYQMYDYSLDMWSLGCMLASMIFRKE---PFFHGHDNYDQLVRIAKVLGTEDL 254
              E L D ++Y    D+W+ G  +  +  R     P    H+ YD L+   ++   ED 
Sbjct: 218 IAIESLAD-RVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDC 276

Query: 255 YD 256
            D
Sbjct: 277 LD 278


>5L6P-A nrPDB
          Length = 298

 Score = 37.0 bits (84), Expect = 0.017,   Method: Compositional matrix adjust.
 Identities = 48/229 (20%), Positives = 93/229 (40%), Gaps = 24/229 (10%)

Query: 25  DYESHVVEWGNQDDYQLVR---KLGRGKYSEVFEAINITNNEK---VVVKILKPVKKKKI 78
           D    V E+  + D   V+    +G G++ EV          +   V +K LK    ++ 
Sbjct: 4   DPNEAVREFAKEIDVSCVKIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQ 63

Query: 79  KREIKILENLRGG---PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ----TLTDY 131
           +R+     ++ G    PNII L  +V    SR   ++ E + N       +      T  
Sbjct: 64  RRDFLSEASIMGQFDHPNIIRLEGVVTK--SRPVMILTEFMENCALDSFLRLNDGQFTVI 121

Query: 132 DIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH---PGQEY 188
            +   +  I   + Y   M  +HRD+   N+++ + +   ++ D+GL+ F         Y
Sbjct: 122 QLVGMLRGIAAGMKYLSEMNYVHRDLAARNILV-NSNLVCKVSDFGLSRFLEDDPSDPTY 180

Query: 189 NVRVASRY---FKGPELLVDYQMYDYSLDMWSLG-CMLASMIFRKEPFF 233
              +  +    +  PE +  Y+ +  + D+WS G  M   M + + P++
Sbjct: 181 TSSLGGKIPIRWTAPEAIA-YRKFTSASDVWSYGIVMWEVMSYGERPYW 228


>2Y6O-A nrPDB
          Length = 291

 Score = 36.6 bits (83), Expect = 0.017,   Method: Compositional matrix adjust.
 Identities = 44/212 (20%), Positives = 91/212 (42%), Gaps = 25/212 (11%)

Query: 40  QLVRKLGRGKYSEVFEA-INITNNEKVVV--KILKPVKKKKIKREIKILENLRGG---PN 93
           ++ + +G G++ EV    + +    ++ V  K LK     K +R+     ++ G    PN
Sbjct: 17  KIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHPN 76

Query: 94  IITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEIL-------KALDY 146
           II L  +V     +   ++ E++ N         L   D RF + +++         + Y
Sbjct: 77  IIHLEGVVTK--CKPVMIITEYMENGSLDAF---LRKNDGRFTVIQLVGMLRGIGSGMKY 131

Query: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH--PGQEYNVRVAS--RYFKGPEL 202
              M  +HRD+   N+++ + +   ++ D+G++      P   Y  R       +  PE 
Sbjct: 132 LSDMSYVHRDLAARNILV-NSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEA 190

Query: 203 LVDYQMYDYSLDMWSLG-CMLASMIFRKEPFF 233
           +  Y+ +  + D+WS G  M   M + + P++
Sbjct: 191 IA-YRKFTSASDVWSYGIVMWEVMSYGERPYW 221


>2QKW-B nrPDB
          Length = 321

 Score = 36.6 bits (83), Expect = 0.017,   Method: Compositional matrix adjust.
 Identities = 26/91 (28%), Positives = 49/91 (53%), Gaps = 11/91 (12%)

Query: 142 KALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKG-- 199
           + L Y H+  I+HRDVK  N+++D E+   ++ D+G+++    G E +    S   KG  
Sbjct: 150 RGLHYLHTRAIIHRDVKSINILLD-ENFVPKITDFGISK---KGTELDQTHLSTVVKGTL 205

Query: 200 ----PELLVDYQMYDYSLDMWSLGCMLASMI 226
               PE  +  ++ + S D++S G +L  ++
Sbjct: 206 GYIDPEYFIKGRLTEKS-DVYSFGVVLFEVL 235


>2OZO-A nrPDB
          Length = 613

 Score = 36.6 bits (83), Expect = 0.017,   Method: Compositional matrix adjust.
 Identities = 39/204 (19%), Positives = 92/204 (45%), Gaps = 21/204 (10%)

Query: 44  KLGRGKYSEVFEAINITNNEK--VVVKILKPVKKK----KIKREIKILENLRGGPNIITL 97
           +LG G +  V + +     ++  V +K+LK   +K    ++ RE +I+  L   P I+ L
Sbjct: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQL-DNPYIVRL 401

Query: 98  ADIVKDPVSRTPALVFEHVNNTDFKQLY----QTLTDYDIRFYMYEILKALDYCHSMGIM 153
             + +   +    LV E        +      + +   ++   ++++   + Y      +
Sbjct: 402 IGVCQ---AEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFV 458

Query: 154 HRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE-YNVRVASRY---FKGPELLVDYQMY 209
           HR++   NV++ + H   ++ D+GL++        Y  R A ++   +  PE  ++++ +
Sbjct: 459 HRNLAARNVLLVNRHYA-KISDFGLSKALGADDSYYTARSAGKWPLKWYAPE-CINFRKF 516

Query: 210 DYSLDMWSLG-CMLASMIFRKEPF 232
               D+WS G  M  ++ + ++P+
Sbjct: 517 SSRSDVWSYGVTMWEALSYGQKPY 540


>5WNO-A nrPDB
          Length = 330

 Score = 36.6 bits (83), Expect = 0.017,   Method: Compositional matrix adjust.
 Identities = 40/204 (19%), Positives = 85/204 (41%), Gaps = 12/204 (5%)

Query: 40  QLVRKLGRGKYSEVFEAINITNNEK-----VVVKILKPVKKK--KIKREIKILENLRGGP 92
           +L +KLG G +  VF  I      K     V +K+ +  + +  ++  E   +  LR   
Sbjct: 25  KLDKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTDQSQTDEMLEEATNMFRLRHDN 84

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNTDFKQLY-QTLTDYDIRFYMYEILKALDYCHSMG 151
            +  +   + D   +   +     N  +F +L+ + L   +   Y Y+I   + Y     
Sbjct: 85  LLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKENLGAREQVLYCYQIASGMQYLEKQR 144

Query: 152 IMHRDVKPHNVMIDHEHRKLRLIDWGLAEFY-HPGQEYNVRVASRYFKGPEL-LVDYQMY 209
           ++HRD+   NV++  +   + + D+GL++   H      ++      K   + +     Y
Sbjct: 145 VVHRDLATRNVLV-KKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIEIFSKHCY 203

Query: 210 DYSLDMWSLGCMLASMI-FRKEPF 232
            ++ D+W+ G     +I F + P+
Sbjct: 204 THASDVWAFGVTCWEIITFGQSPY 227


>1U59-A nrPDB
          Length = 287

 Score = 36.6 bits (83), Expect = 0.017,   Method: Compositional matrix adjust.
 Identities = 40/204 (19%), Positives = 92/204 (45%), Gaps = 21/204 (10%)

Query: 44  KLGRGKYSEVFEAINITNNEK--VVVKILKPVKKK----KIKREIKILENLRGGPNIITL 97
           +LG G +  V + +     ++  V +K+LK   +K    ++ RE +I+  L   P I+ L
Sbjct: 17  ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQL-DNPYIVRL 75

Query: 98  ADIVKDPVSRTPALVFEHVNNTDFKQLY----QTLTDYDIRFYMYEILKALDYCHSMGIM 153
             + +   +    LV E        +      + +   ++   ++++   + Y      +
Sbjct: 76  IGVCQ---AEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFV 132

Query: 154 HRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE-YNVRVASRY---FKGPELLVDYQMY 209
           HRD+   NV++ + H   ++ D+GL++        Y  R A ++   +  PE  ++++ +
Sbjct: 133 HRDLAARNVLLVNRHYA-KISDFGLSKALGADDSYYTARSAGKWPLKWYAPE-CINFRKF 190

Query: 210 DYSLDMWSLGC-MLASMIFRKEPF 232
               D+WS G  M  ++ + ++P+
Sbjct: 191 SSRSDVWSYGVTMWEALSYGQKPY 214


>2Y4I-B nrPDB
          Length = 319

 Score = 36.6 bits (83), Expect = 0.019,   Method: Compositional matrix adjust.
 Identities = 22/64 (34%), Positives = 34/64 (53%), Gaps = 9/64 (14%)

Query: 122 KQLYQTLTDYDI-------RFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLI 174
           + LY  + D  I       R    EI+K + Y H+ GI+H+D+K  NV  D+   K+ + 
Sbjct: 114 RTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYDNG--KVVIT 171

Query: 175 DWGL 178
           D+GL
Sbjct: 172 DFGL 175


>5CLR-A nrPDB
          Length = 451

 Score = 36.2 bits (82), Expect = 0.024,   Method: Compositional matrix adjust.
 Identities = 17/60 (28%), Positives = 32/60 (53%), Gaps = 7/60 (11%)

Query: 118 NTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWG 177
           N + K  ++ L        M  +   +   H +G++HRD+KP N+M+D +  +  L+D+G
Sbjct: 169 NVNLKHFWEVLG------IMISVCHQVKQFHELGLIHRDLKPGNIMLDAD-MQCHLVDFG 221


>1BYG-A nrPDB
          Length = 278

 Score = 36.2 bits (82), Expect = 0.024,   Method: Compositional matrix adjust.
 Identities = 41/195 (21%), Positives = 88/195 (45%), Gaps = 16/195 (8%)

Query: 35  NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK-PVKKKKIKREIKILENLRGGPN 93
           N  + +L++ +G+G++ +V   +      KV VK +K     +    E  ++  LR    
Sbjct: 19  NMKELKLLQTIGKGEFGDVM--LGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNL 76

Query: 94  IITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLT------DYDIRFYMYEILKALDYC 147
           +  L  IV++       +V E++         ++        D  ++F + ++ +A++Y 
Sbjct: 77  VQLLGVIVEEKGGLY--IVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSL-DVCEAMEYL 133

Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQ 207
                +HRD+   NV++  E    ++ D+GL +     Q+   ++  ++   PE L + +
Sbjct: 134 EGNNFVHRDLAARNVLVS-EDNVAKVSDFGLTKEASSTQDTG-KLPVKW-TAPEALREKK 190

Query: 208 MYDYSLDMWSLGCML 222
               S D+WS G +L
Sbjct: 191 FSTKS-DVWSFGILL 204


>1K9A-A nrPDB
          Length = 450

 Score = 36.2 bits (82), Expect = 0.028,   Method: Compositional matrix adjust.
 Identities = 41/195 (21%), Positives = 88/195 (45%), Gaps = 16/195 (8%)

Query: 35  NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK-PVKKKKIKREIKILENLRGGPN 93
           N  + +L++ +G+G++ +V   +      KV VK +K     +    E  ++  LR    
Sbjct: 191 NMKELKLLQTIGKGEFGDVM--LGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNL 248

Query: 94  IITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLT------DYDIRFYMYEILKALDYC 147
           +  L  IV++       +V E++         ++        D  ++F + ++ +A++Y 
Sbjct: 249 VQLLGVIVEEKGGLY--IVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSL-DVCEAMEYL 305

Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQ 207
                +HRD+   NV++  E    ++ D+GL +     Q+   ++  ++   PE L + +
Sbjct: 306 EGNNFVHRDLAARNVLVS-EDNVAKVSDFGLTKEASSTQDTG-KLPVKW-TAPEALREKK 362

Query: 208 MYDYSLDMWSLGCML 222
               S D+WS G +L
Sbjct: 363 FSTKS-DVWSFGILL 376


>4PDO-A nrPDB
          Length = 299

 Score = 35.8 bits (81), Expect = 0.029,   Method: Compositional matrix adjust.
 Identities = 44/210 (20%), Positives = 93/210 (44%), Gaps = 28/210 (13%)

Query: 45  LGRGKYSEVFEAINITNNEK----VVVKILKPVKKKKIKREIKILENLRGG---PNIITL 97
           +G G++ EV++ +  T++ K    V +K LK    +K + +      + G     NII L
Sbjct: 42  IGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQFSHHNIIRL 101

Query: 98  ADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYE-------ILKALDYCHSM 150
             ++     +   ++ E++ N    +    L + D  F + +       I   + Y  +M
Sbjct: 102 EGVISK--YKPMMIITEYMENGALDKF---LREKDGEFSVLQLVGMLRGIAAGMKYLANM 156

Query: 151 GIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH--PGQEYNV---RVASRYFKGPELLVD 205
             +HRD+   N++++  +   ++ D+GL+      P   Y     ++  R+   PE  + 
Sbjct: 157 NYVHRDLAARNILVN-SNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRW-TAPE-AIS 213

Query: 206 YQMYDYSLDMWSLG-CMLASMIFRKEPFFH 234
           Y+ +  + D+WS G  M   M + + P++ 
Sbjct: 214 YRKFTSASDVWSFGIVMWEVMTYGERPYWE 243


>3G2F-A nrPDB
          Length = 336

 Score = 35.0 bits (79), Expect = 0.051,   Method: Compositional matrix adjust.
 Identities = 64/318 (20%), Positives = 130/318 (40%), Gaps = 53/318 (16%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKRE-----IKILENLRGG 91
           D+ +L+  +GRG+Y  V++     +   V VK+     ++    E     + ++E+    
Sbjct: 13  DNLKLLELIGRGRYGAVYKG--SLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIA 70

Query: 92  PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYM-YEILKALDYCHSM 150
             I+    +  D       ++  + N +  K L    +D+     + + + + L Y H+ 
Sbjct: 71  RFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTE 130

Query: 151 ---------GIMHRDVKPHNVMIDHEHRKLRLIDWGLA------EFYHPGQEYNV---RV 192
                     I HRD+   NV++ ++   + + D+GL+          PG+E N     V
Sbjct: 131 LPRGDHYKPAISHRDLNSRNVLVKNDGTCV-ISDFGLSMRLTGNRLVRPGEEDNAAISEV 189

Query: 193 ASRYFKGPELLV------DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIA 246
            +  +  PE+L       D +     +DM++LG +   +  R    F G           
Sbjct: 190 GTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPG----------- 238

Query: 247 KVLGTEDLYDYIDKYNIELD--PRFNDILGRHSR-KRWERFVHSENQHLVSPEAL-DFLD 302
                E + +Y   +  E+   P F D+    SR K+  +F  +  ++ ++  +L + ++
Sbjct: 239 -----ESVPEYQMAFQTEVGNHPTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKETIE 293

Query: 303 KLLRYDHQSRLTAREAME 320
                D ++RLTA+ A E
Sbjct: 294 DCWDQDAEARLTAQCAEE 311


>3BIQ-A nrPDB
          Length = 467

 Score = 35.0 bits (79), Expect = 0.054,   Method: Compositional matrix adjust.
 Identities = 29/121 (23%), Positives = 51/121 (42%), Gaps = 26/121 (21%)

Query: 173 LIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLG------CMLASMI 226
           L+DW  +     G+++++RV++R         + Q+Y     + S G      C   +  
Sbjct: 254 LLDWTYSPIIQSGKKFDLRVSARS-------TNDQLYGNGCILASCGIRYNNYCSNITRT 306

Query: 227 FRKEPFFHGHDNYDQLVRIAKVLGT-------------EDLYDYIDKYNIELDPRFNDIL 273
           F  +P     +NYD L+ + K + T             E + +YI+K   EL P F   +
Sbjct: 307 FLIDPSEEMANNYDFLLTLQKEIVTNILKPGRTPKEVYESVIEYIEKTKPELVPNFTKNI 366

Query: 274 G 274
           G
Sbjct: 367 G 367


>3ZBF-A nrPDB
          Length = 322

 Score = 34.3 bits (77), Expect = 0.089,   Method: Compositional matrix adjust.
 Identities = 27/111 (24%), Positives = 49/111 (44%), Gaps = 8/111 (7%)

Query: 139 EILKALDYCHSMGIMHRDVKPHNVMIDHEH----RKLRLIDWGLAEFYHPGQEYNVR--- 191
           +I K   Y   M  +HRD+   N ++  +     R +++ D+GLA   +    Y  R   
Sbjct: 152 DISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEG 211

Query: 192 VASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQL 242
           +    +  PE L+D  ++    D+WS G ++  ++      +  H N D L
Sbjct: 212 LLPVRWMAPESLMD-GIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVL 261


>4FL3-A nrPDB
          Length = 635

 Score = 34.3 bits (77), Expect = 0.097,   Method: Compositional matrix adjust.
 Identities = 38/177 (21%), Positives = 74/177 (41%), Gaps = 23/177 (12%)

Query: 72  PVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---L 128
           P  K ++  E  +++ L   P I+ +  I +   + +  LV E        +  Q    +
Sbjct: 411 PALKDELLAEANVMQQLDN-PYIVRMIGICE---AESWMLVMEMAELGPLNKYLQQNRHV 466

Query: 129 TDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA------EFY 182
            D +I   ++++   + Y      +HRD+   NV++  +H   ++ D+GL+      E Y
Sbjct: 467 KDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYA-KISDFGLSKALRADENY 525

Query: 183 HPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNY 239
           +  Q +       Y   PE  ++Y  +    D+WS G ++       E F +G   Y
Sbjct: 526 YKAQTHGKWPVKWY--APE-CINYYKFSSKSDVWSFGVLMW------EAFSYGQKPY 573


>5TOS-A nrPDB
          Length = 395

 Score = 33.9 bits (76), Expect = 0.12,   Method: Compositional matrix adjust.
 Identities = 27/98 (27%), Positives = 49/98 (50%), Gaps = 7/98 (7%)

Query: 142 KALDYCHS--MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPG--QEYNVRVASRY- 196
           K L + HS  + +++RD+K  N+++D ++   +L D+GLA     G     + RV   Y 
Sbjct: 186 KGLAFLHSDPVKVIYRDIKASNILLDADYNA-KLSDFGLARDGPMGDLSYVSTRVMGTYG 244

Query: 197 FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFH 234
           +  PE +    +   S D++S G +L  ++  K    H
Sbjct: 245 YAAPEYMSSGHLNARS-DVYSFGVLLLEILSGKRALDH 281


>4AZV-A nrPDB
          Length = 569

 Score = 33.5 bits (75), Expect = 0.15,   Method: Compositional matrix adjust.
 Identities = 27/103 (26%), Positives = 44/103 (42%), Gaps = 3/103 (2%)

Query: 75  KKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIR 134
           K ++  EIK L     G +    A +     +++  LV E +       +     + D  
Sbjct: 285 KYELHNEIKFLTQPPAGFD--APAVLAHGENAQSGWLVMEKLPGRLLSDMLAAGEEIDRE 342

Query: 135 FYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWG 177
             +  +L++L      G  H DV+P NVM+D      RLID+G
Sbjct: 343 KILGSLLRSLAALEKQGFWHDDVRPWNVMVDARQHA-RLIDFG 384


>3UIM-A nrPDB
          Length = 326

 Score = 33.5 bits (75), Expect = 0.16,   Method: Compositional matrix adjust.
 Identities = 50/205 (24%), Positives = 92/205 (44%), Gaps = 24/205 (11%)

Query: 45  LGRGKYSEVFEAINITNNEKVVVKILKPVKKK----KIKREIKILENLRGGPNIITLADI 100
           LGRG + +V++   + +   V VK LK  + +    + + E++++ ++    N++ L   
Sbjct: 38  LGRGGFGKVYKG-RLADGTLVAVKRLKEERTQGGELQFQTEVEMI-SMAVHRNLLRLRGF 95

Query: 101 VKDPVSRTPALVFEHVNNTDFKQLY------QTLTDYDIRFYM-YEILKALDYCHSMG-- 151
              P  R   LV+ ++ N             Q   D+  R  +     + L Y H     
Sbjct: 96  CMTPTERL--LVYPYMANGSVASCLRERPESQPPLDWPKRQRIALGSARGLAYLHDHCDP 153

Query: 152 -IMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKG---PELLVDYQ 207
            I+HRDVK  N+++D E   + + D+GLA+     ++ +V  A R   G   PE L   +
Sbjct: 154 KIIHRDVKAANILLDEEFEAV-VGDFGLAKLMDY-KDTHVTTAVRGTIGHIAPEYLSTGK 211

Query: 208 MYDYSLDMWSLGCMLASMIFRKEPF 232
             + + D++  G ML  +I  +  F
Sbjct: 212 SSEKT-DVFGYGVMLLELITGQRAF 235


>5C26-A nrPDB
          Length = 299

 Score = 33.5 bits (75), Expect = 0.18,   Method: Compositional matrix adjust.
 Identities = 38/177 (21%), Positives = 74/177 (41%), Gaps = 23/177 (12%)

Query: 72  PVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---L 128
           P  K ++  E  +++ L   P I+ +  I +   + +  LV E        +  Q    +
Sbjct: 69  PALKDELLAEANVMQQL-DNPYIVRMIGICE---AESWMLVMEMAELGPLNKYLQQNRHV 124

Query: 129 TDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA------EFY 182
            D +I   ++++   + Y      +HRD+   NV++  +H   ++ D+GL+      E Y
Sbjct: 125 KDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYA-KISDFGLSKALRADENY 183

Query: 183 HPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNY 239
           +  Q +       Y   PE  ++Y  +    D+WS G ++       E F +G   Y
Sbjct: 184 YKAQTHGKWPVKWY--APE-CINYYKFSSKSDVWSFGVLMW------EAFSYGQKPY 231


>4AZW-A nrPDB
          Length = 471

 Score = 33.5 bits (75), Expect = 0.18,   Method: Compositional matrix adjust.
 Identities = 27/104 (25%), Positives = 44/104 (42%), Gaps = 3/104 (2%)

Query: 74  KKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDI 133
            K ++  EIK L     G +    A +     +++  LV E +       +     + D 
Sbjct: 284 NKHELHNEIKFLTQPPAGFD--APAVLAHGENAQSGWLVMEKLPGRLLSDMLAAGEEIDR 341

Query: 134 RFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWG 177
              +  +L++L      G  H DV+P NVM+D      RLID+G
Sbjct: 342 EKILGSLLRSLAALEKKGFWHDDVRPWNVMVDARQHA-RLIDFG 384


>2RSV-A nrPDB
          Length = 403

 Score = 33.1 bits (74), Expect = 0.22,   Method: Compositional matrix adjust.
 Identities = 16/46 (34%), Positives = 30/46 (65%), Gaps = 1/46 (2%)

Query: 140 ILKALDYCHSMGIMHRDVKPHNVMIDHEH-RKLRLIDWGLAEFYHP 184
           IL  L+Y H    +H D+K  N+++++++  ++ L+D+GLA  Y P
Sbjct: 168 ILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCP 213


>4O1O-A nrPDB
          Length = 717

 Score = 32.7 bits (73), Expect = 0.24,   Method: Compositional matrix adjust.
 Identities = 22/93 (23%), Positives = 39/93 (41%), Gaps = 7/93 (7%)

Query: 79  KREIKILENLRGGPNIITLADIVKDPVSRTPALVF------EHVNNTDFKQLYQTLTDYD 132
           ++E+  L++ R   N++T      D       L        EH+ N     +     D  
Sbjct: 385 QQEVSCLQSSRANDNVVTFYGSESDGSCLHVCLALCEYTLQEHLANHRGDAVPNE-EDES 443

Query: 133 IRFYMYEILKALDYCHSMGIMHRDVKPHNVMID 165
            R  +  + KA+   H  G  H+D++P N++ID
Sbjct: 444 ARNILSSLFKAIGELHRSGYSHQDLQPQNILID 476


>5VC6-A nrPDB
          Length = 289

 Score = 32.7 bits (73), Expect = 0.25,   Method: Compositional matrix adjust.
 Identities = 11/37 (29%), Positives = 23/37 (62%)

Query: 128 LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMI 164
             + +++  + ++ + L Y HSM ++H D+KP N+ I
Sbjct: 112 FKEAELKDLLLQVGRGLRYIHSMSLVHMDIKPSNIFI 148


>6G4J-A nrPDB
          Length = 315

 Score = 32.7 bits (73), Expect = 0.25,   Method: Compositional matrix adjust.
 Identities = 31/151 (20%), Positives = 64/151 (42%), Gaps = 8/151 (5%)

Query: 32  EWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKI----LKPVKKKKIKREIKILEN 87
           +W N + Y L ++LG+G    V+ A   T++  V +K+    L    +  + +     ++
Sbjct: 22  KW-NGNTYTLRKQLGKGANGIVYLAE--TSDGHVALKVSDDSLSITSEVNVLKSFSKAQS 78

Query: 88  LRGGPNIITLADI-VKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDY 146
           +  GP+     D  +    ++      E++      +         I   M ++L +L  
Sbjct: 79  VTMGPSFFDTDDAYIPSANTKVSFYAMEYIKGPLLLKYVSDKGAEWIPVLMIQLLSSLSV 138

Query: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWG 177
            H  G +  D+KP N+++     ++R ID G
Sbjct: 139 LHQQGWIFGDLKPDNLIVTGPPARIRCIDVG 169


>2LAV-A nrPDB
          Length = 361

 Score = 32.7 bits (73), Expect = 0.26,   Method: Compositional matrix adjust.
 Identities = 16/46 (34%), Positives = 30/46 (65%), Gaps = 1/46 (2%)

Query: 140 ILKALDYCHSMGIMHRDVKPHNVMIDHEH-RKLRLIDWGLAEFYHP 184
           IL  L+Y H    +H D+K  N+++++++  ++ L+D+GLA  Y P
Sbjct: 161 ILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCP 206


>5XD6-A nrPDB
          Length = 305

 Score = 32.3 bits (72), Expect = 0.33,   Method: Compositional matrix adjust.
 Identities = 43/217 (19%), Positives = 86/217 (39%), Gaps = 24/217 (11%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK--KKIKREIKILENLRGGPNI 94
           D+Y     +G G Y  VF  I + + +   +K L   K+  ++   ++ ++  LR    +
Sbjct: 22  DNYGSKSLIGEGSYGRVFYGI-LKSGKAAAIKKLDSSKQPDQEFLAQVSMVSRLRQENVV 80

Query: 95  ITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ------------TLTDYDIRFYMYEILK 142
             L   V  P+     L +E+  N     +               L+ +          +
Sbjct: 81  ALLGYCVDGPLR---VLAYEYAPNGSLHDILHGRKGVKGAQPGPVLSWHQRVKIAVGAAR 137

Query: 143 ALDYCHSMG---IMHRDVKPHNVMI-DHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY-F 197
            L+Y H      ++HRD+K  NV++ D +  K+   D          + ++ RV   + +
Sbjct: 138 GLEYLHEKANPHVIHRDIKSSNVLLFDDDVAKIADFDLSNQAPDMAARLHSTRVLGTFGY 197

Query: 198 KGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFH 234
             PE  +   +   S D++S G +L  ++  ++P  H
Sbjct: 198 HAPEYAMTGTLSTKS-DVYSFGVVLLELLTGRKPVDH 233


>6BFN-A nrPDB
          Length = 342

 Score = 32.0 bits (71), Expect = 0.54,   Method: Compositional matrix adjust.
 Identities = 40/157 (25%), Positives = 63/157 (40%), Gaps = 28/157 (17%)

Query: 44  KLGRGKYSEVFEAINITNNEKVVVKILK-------PVKKKKIKREIKILENLRGGPNIIT 96
           K+G G +  V+ A+    N    VK LK          K+    E++ L   R  PNI+ 
Sbjct: 29  KIGEGGFGCVYRAV--MRNTVYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRH-PNIVD 85

Query: 97  LADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTD----------YDIRFYMYEILKALDY 146
            A       +    LV+  + N   +      T            DI   +    +A+ +
Sbjct: 86  FAGYCAQ--NGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDI---LLGTARAIQF 140

Query: 147 CH--SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF 181
            H  S  ++H D+K  NV++D E    +L D+GLA F
Sbjct: 141 LHQDSPSLIHGDIKSSNVLLD-ERLTPKLGDFGLARF 176


>3SXS-A nrPDB
          Length = 268

 Score = 31.6 bits (70), Expect = 0.61,   Method: Compositional matrix adjust.
 Identities = 19/88 (21%), Positives = 44/88 (50%), Gaps = 6/88 (6%)

Query: 138 YEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY- 196
           Y++ + + +  S   +HRD+   N ++D +   +++ D+G+  +    Q Y   V +++ 
Sbjct: 111 YDVCEGMAFLESHQFIHRDLAARNCLVDRD-LCVKVSDFGMTRYVLDDQ-YVSSVGTKFP 168

Query: 197 --FKGPELLVDYQMYDYSLDMWSLGCML 222
             +  PE+   Y  Y    D+W+ G ++
Sbjct: 169 VKWSAPEVF-HYFKYSSKSDVWAFGILM 195


>5UIU-A nrPDB
          Length = 323

 Score = 30.8 bits (68), Expect = 1.1,   Method: Compositional matrix adjust.
 Identities = 34/149 (22%), Positives = 65/149 (43%), Gaps = 19/149 (12%)

Query: 44  KLGRGKYSEVFEAINITNNEKVVVKILKPVK-------KKKIKREIKILENLRGGPNIIT 96
           K+G G +  V++     NN  V VK L  +        K++  +EIK++   +   N++ 
Sbjct: 54  KMGEGGFGVVYKGY--VNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQH-ENLVE 110

Query: 97  LADIVKDPVSRTPALVFEHVNNTDFKQLYQTL-----TDYDIRFYMYE-ILKALDYCHSM 150
           L     D       LV+ ++ N         L       + +R  + +     +++ H  
Sbjct: 111 LLGFSSD--GDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHEN 168

Query: 151 GIMHRDVKPHNVMIDHEHRKLRLIDWGLA 179
             +HRD+K  N+++D E    ++ D+GLA
Sbjct: 169 HHIHRDIKSANILLD-EAFTAKISDFGLA 196


>3LMG-A nrPDB
          Length = 344

 Score = 30.4 bits (67), Expect = 1.2,   Method: Compositional matrix adjust.
 Identities = 24/97 (24%), Positives = 47/97 (48%), Gaps = 4/97 (4%)

Query: 139 EILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHP-GQEYNVRVASRYF 197
           +I K + Y    G++HR++   NV++     ++++ D+G+A+   P  ++     A    
Sbjct: 141 QIAKGMYYLEEHGMVHRNLAARNVLLKSP-SQVQVADFGVADLLPPDDKQLLYSEAKTPI 199

Query: 198 KGPEL-LVDYQMYDYSLDMWSLGCMLAS-MIFRKEPF 232
           K   L  + +  Y +  D+WS G  +   M F  EP+
Sbjct: 200 KWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEPY 236


>5LPZ-A nrPDB
          Length = 332

 Score = 30.4 bits (67), Expect = 1.4,   Method: Compositional matrix adjust.
 Identities = 24/85 (28%), Positives = 43/85 (50%), Gaps = 9/85 (10%)

Query: 152 IMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEY---NVRVASRYFKGPELLVDYQM 208
           I+HRD+K  NV++D E+ + R+ D+G+A        +   +    +  +  PE    YQ 
Sbjct: 141 IIHRDMKSSNVLLD-ENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEY---YQS 196

Query: 209 YDYSL--DMWSLGCMLASMIFRKEP 231
           +  S   D++S G +L  ++  K P
Sbjct: 197 FRCSTKGDVYSYGVVLLELLTGKRP 221


>3JB4-B nrPDB
          Length = 259

 Score = 30.4 bits (67), Expect = 1.4,   Method: Compositional matrix adjust.
 Identities = 21/102 (20%), Positives = 42/102 (41%), Gaps = 7/102 (6%)

Query: 160 HNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLG 219
           H     ++HR+  +    L + + P Q++     SRYF         Q+   ++++ S G
Sbjct: 93  HGTWTTNQHRQALVASITLLQAFWPNQDFPAWGQSRYFAAVRCGFHIQV-QLNVNIGSAG 151

Query: 220 CMLASMIFRKEP------FFHGHDNYDQLVRIAKVLGTEDLY 255
           C++A+ + +          F  + N   ++  A      DLY
Sbjct: 152 CLIAAYMPKTAHDHMNTYTFGSYTNLPHVLMNAATTSQADLY 193


>6J6I-B nrPDB
          Length = 351

 Score = 30.0 bits (66), Expect = 1.6,   Method: Compositional matrix adjust.
 Identities = 22/68 (32%), Positives = 33/68 (48%), Gaps = 11/68 (16%)

Query: 109 PALVFEHVNNTDFKQL-------YQTLTDYDIRFYM-YEILKALDYCHSMG---IMHRDV 157
           P LVFE   +    Q         ++L  + +R  +  EI  A+ Y H+     I+HRDV
Sbjct: 133 PVLVFEFAEHGAMNQRGGVIVNGEESLLPWSVRLKIGKEIANAVTYLHTAFPKIIIHRDV 192

Query: 158 KPHNVMID 165
           KP +V +D
Sbjct: 193 KPMHVFLD 200


>5VDK-A nrPDB
          Length = 297

 Score = 30.0 bits (66), Expect = 1.6,   Method: Compositional matrix adjust.
 Identities = 11/31 (35%), Positives = 20/31 (64%)

Query: 137 MYEILKALDYCHSMGIMHRDVKPHNVMIDHE 167
           + +I   L+Y H+  ++H D+KP N+ I H+
Sbjct: 125 LLQISLGLNYIHNSSMVHLDIKPSNIFICHK 155


>5LPV-A nrPDB
          Length = 296

 Score = 30.0 bits (66), Expect = 1.8,   Method: Compositional matrix adjust.
 Identities = 24/85 (28%), Positives = 43/85 (50%), Gaps = 9/85 (10%)

Query: 152 IMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEY---NVRVASRYFKGPELLVDYQM 208
           I+HRD+K  NV++D E+ + R+ D+G+A        +   +    +  +  PE    YQ 
Sbjct: 141 IIHRDMKSSNVLLD-ENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEY---YQS 196

Query: 209 YDYSL--DMWSLGCMLASMIFRKEP 231
           +  S   D++S G +L  ++  K P
Sbjct: 197 FRCSTKGDVYSYGVVLLELLTGKRP 221


>1JKF-A nrPDB
          Length = 533

 Score = 29.6 bits (65), Expect = 2.5,   Method: Compositional matrix adjust.
 Identities = 14/48 (29%), Positives = 28/48 (58%)

Query: 65  VVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALV 112
           +V+K +KPV   K+  +    E + GG N I++ ++ +D +  TP ++
Sbjct: 400 IVIKYMKPVGDSKVAMDEYYSELMLGGHNRISIHNVCEDSLLATPLII 447


>4V1O-Q nrPDB
          Length = 734

 Score = 29.3 bits (64), Expect = 3.2,   Method: Compositional matrix adjust.
 Identities = 16/48 (33%), Positives = 24/48 (50%), Gaps = 4/48 (8%)

Query: 314 TAREAMEHPYFYTVVKDQARMGSSSM----PGGSTPVSSANMMSGISS 357
           TAR+  + P   + +KD A  G +SM     G S P +S N  S + +
Sbjct: 193 TARDGSQTPVIDSAIKDNATNGVNSMTATATGSSVPPASPNPASAVEN 240


>4OAU-C nrPDB
          Length = 699

 Score = 28.9 bits (63), Expect = 4.0,   Method: Compositional matrix adjust.
 Identities = 13/33 (39%), Positives = 20/33 (60%), Gaps = 1/33 (3%)

Query: 134 RFYMYEILKALDYCH-SMGIMHRDVKPHNVMID 165
           R  +  I KA+   H S G  H+D++P N++ID
Sbjct: 442 RNVLSSIFKAVQELHLSCGYTHQDLQPQNILID 474


>5UU1-A nrPDB
          Length = 324

 Score = 28.5 bits (62), Expect = 5.0,   Method: Compositional matrix adjust.
 Identities = 20/68 (29%), Positives = 36/68 (52%), Gaps = 8/68 (11%)

Query: 118 NTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEH-RKLRLIDW 176
           N  FK+   T+    IR     +L  L+Y H    +H D+K  N+++ +++  ++ L D+
Sbjct: 124 NGTFKK--STVLQLGIR-----MLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADY 176

Query: 177 GLAEFYHP 184
           GL+  Y P
Sbjct: 177 GLSYRYCP 184


>3LY6-A nrPDB
          Length = 697

 Score = 28.5 bits (62), Expect = 5.3,   Method: Compositional matrix adjust.
 Identities = 16/49 (32%), Positives = 25/49 (51%), Gaps = 2/49 (4%)

Query: 1   MSGPVPSRARVYTDVNTH--RPREYWDYESHVVEWGNQDDYQLVRKLGR 47
             GPVP RA    D++T    P  + +  + VV+W  QDD  + + + R
Sbjct: 370 CCGPVPVRAIKEGDLSTKYDAPFVFAEVNADVVDWIQQDDGSVHKSINR 418


>4W6Q-A nrPDB
          Length = 333

 Score = 28.5 bits (62), Expect = 5.4,   Method: Compositional matrix adjust.
 Identities = 17/50 (34%), Positives = 24/50 (48%), Gaps = 7/50 (14%)

Query: 5   VPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVF 54
           +P+   VYTD N   P       + VV+   Q D QL+ K+  G Y  V+
Sbjct: 190 IPTELHVYTDHNMQLP-------TTVVKEPYQSDEQLIMKMSEGGYGLVW 232


>5OAT-A nrPDB
          Length = 411

 Score = 28.5 bits (62), Expect = 5.6,   Method: Compositional matrix adjust.
 Identities = 23/98 (23%), Positives = 43/98 (43%), Gaps = 15/98 (15%)

Query: 151 GIMHRDVKPHNVMIDH---EHRKLRLIDWGLA------EFYHPGQEYNV-RVASRYFKGP 200
           GI HRD+K  N+++D    E   L + D+G            P   Y + +  +     P
Sbjct: 173 GIAHRDLKSDNLLLDTSEPESPILVISDFGCCLADKTNGLSLPYTSYEMDKGGNTALMAP 232

Query: 201 ELLVD----YQMYDYS-LDMWSLGCMLASMIFRKEPFF 233
           E++      + + +YS  D+W++G +   +     PF+
Sbjct: 233 EIICQKPGTFSVLNYSKADLWAVGAIAYEIFNCHNPFY 270


Searching..................................................done


Results from round 2


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value
Sequences used in model and found again:

4MD7-E nrPDB                                                          566   e-162
6EII-A nrPDB                                                          478   e-135
6HMD-A nrPDB                                                          412   e-115
2PVN-A nrPDB                                                          386   e-108
6O6Q-A nrPDB                                                          386   e-107
5XVU-A nrPDB                                                          365   e-101
4LFI-A nrPDB                                                          329   1e-90
5JN2-A nrPDB                                                          308   2e-84
3NCG-A nrPDB                                                          306   7e-84
5Z33-A nrPDB                                                          305   2e-83
2BPM-A nrPDB                                                          303   9e-83
4EWQ-A nrPDB                                                          300   6e-82
3OHT-A nrPDB                                                          299   1e-81
5AIR-A nrPDB                                                          299   2e-81
3NIZ-A nrPDB                                                          299   2e-81
1CM8-A nrPDB                                                          296   9e-81
3LIJ-A nrPDB                                                          296   1e-80
3HZT-A nrPDB                                                          296   1e-80
4MVF-A nrPDB                                                          296   1e-80
6GU6-A nrPDB                                                          295   3e-80
3MA6-A nrPDB                                                          292   2e-79
4KRC-A nrPDB                                                          291   3e-79
3DFA-A nrPDB                                                          291   4e-79
4MYG-A nrPDB                                                          290   6e-79
1V0B-A nrPDB                                                          290   7e-79
3DXN-A nrPDB                                                          290   7e-79
1G3N-A nrPDB                                                          290   9e-79
4YZB-A nrPDB                                                          289   2e-78
3OZ6-A nrPDB                                                          286   2e-77
4QTB-A nrPDB                                                          285   2e-77
5NGU-A nrPDB                                                          284   3e-77
2F9G-A nrPDB                                                          284   5e-77
4AGU-A nrPDB                                                          284   6e-77
5EFQ-A nrPDB                                                          284   6e-77
3Q5I-A nrPDB                                                          283   1e-76
6DTL-A nrPDB                                                          282   2e-76
3GC9-A nrPDB                                                          281   4e-76
4AU8-A nrPDB                                                          281   5e-76
4NST-A nrPDB                                                          280   8e-76
4RGJ-A nrPDB                                                          279   1e-75
4E7W-A nrPDB                                                          279   1e-75
5FG8-A nrPDB                                                          276   9e-75
3HDN-A nrPDB                                                          276   1e-74
4IC8-A nrPDB                                                          276   1e-74
5AWM-A nrPDB                                                          275   2e-74
2VN9-A nrPDB                                                          275   3e-74
4QNY-A nrPDB                                                          274   3e-74
2BDW-A nrPDB                                                          274   3e-74
3KK8-A nrPDB                                                          273   1e-73
4ZSG-A nrPDB                                                          271   2e-73
4BBM-A nrPDB                                                          271   3e-73
3E7O-A nrPDB                                                          271   3e-73
1UA2-A nrPDB                                                          271   4e-73
5U6Y-A nrPDB                                                          271   5e-73
2V7O-A nrPDB                                                          270   7e-73
2J90-A nrPDB                                                          270   9e-73
2YAB-A nrPDB                                                          269   1e-72
5Y86-A nrPDB                                                          269   2e-72
3MIA-A nrPDB                                                          269   2e-72
1JNK-A nrPDB                                                          269   2e-72
2VZ6-A nrPDB                                                          269   2e-72
2XS0-A nrPDB                                                          268   2e-72
3FI2-A nrPDB                                                          268   3e-72
2A27-A nrPDB                                                          268   4e-72
3BHH-A nrPDB                                                          268   4e-72
3PG1-A nrPDB                                                          268   4e-72
4NIF-A nrPDB                                                          266   9e-72
3SOA-A nrPDB                                                          266   1e-71
2JC6-A nrPDB                                                          265   2e-71
5G6V-A nrPDB                                                          265   2e-71
3GC0-A nrPDB                                                          265   2e-71
5WAX-A nrPDB                                                          264   6e-71
2X4F-A nrPDB                                                          264   6e-71
1ZWS-A nrPDB                                                          263   8e-71
4FG9-A nrPDB                                                          263   1e-70
5IG1-A nrPDB                                                          263   1e-70
2W4O-A nrPDB                                                          263   1e-70
3E3P-A nrPDB                                                          262   2e-70
5ES1-A nrPDB                                                          261   3e-70
5XZW-A nrPDB                                                          261   4e-70
3F3Z-A nrPDB                                                          261   4e-70
2YCR-A nrPDB                                                          261   5e-70
3GUB-A nrPDB                                                          260   9e-70
3RP9-A nrPDB                                                          259   1e-69
4BGQ-A nrPDB                                                          259   1e-69
1PHK-A nrPDB                                                          259   1e-69
4JG6-A nrPDB                                                          259   2e-69
3ZDU-A nrPDB                                                          259   2e-69
5YKS-A nrPDB                                                          259   2e-69
3N9X-A nrPDB                                                          259   2e-69
3MN3-A nrPDB                                                          258   2e-69
3NIE-A nrPDB                                                          258   3e-69
3I6U-A nrPDB                                                          257   6e-69
3UC3-A nrPDB                                                          257   6e-69
2JAM-A nrPDB                                                          257   6e-69
3UTO-A nrPDB                                                          256   9e-69
3TAC-A nrPDB                                                          256   1e-68
2Y7J-A nrPDB                                                          256   1e-68
2QNJ-A nrPDB                                                          256   1e-68
5KCV-A nrPDB                                                          256   1e-68
3H4J-B nrPDB                                                          256   1e-68
3ZUT-A nrPDB                                                          255   2e-68
1KOA-A nrPDB                                                          254   3e-68
2JDO-A nrPDB                                                          254   4e-68
5KZ7-A nrPDB                                                          254   6e-68
2HW6-A nrPDB                                                          254   7e-68
4PDS-A nrPDB                                                          253   7e-68
2W96-B nrPDB                                                          253   8e-68
4O2Z-A nrPDB                                                          253   1e-67
4REW-A nrPDB                                                          253   1e-67
3MV5-A nrPDB                                                          252   2e-67
1KOB-A nrPDB                                                          251   4e-67
1FOT-A nrPDB                                                          251   6e-67
5JZN-A nrPDB                                                          250   8e-67
2HAK-A nrPDB                                                          250   9e-67
4CFH-A nrPDB                                                          250   1e-66
4RED-A nrPDB                                                          250   1e-66
4CFF-A nrPDB                                                          249   1e-66
5EZV-A nrPDB                                                          249   1e-66
5F9E-A nrPDB                                                          249   2e-66
6C9D-A nrPDB                                                          249   2e-66
3D2K-A nrPDB                                                          249   2e-66
3IS5-A nrPDB                                                          248   2e-66
3UDB-A nrPDB                                                          248   3e-66
3KN6-A nrPDB                                                          248   3e-66
3EB0-A nrPDB                                                          247   4e-66
4UZD-A nrPDB                                                          246   9e-66
2YZA-A nrPDB                                                          246   9e-66
5D9K-A nrPDB                                                          246   1e-65
5ZTN-A nrPDB                                                          245   2e-65
4D28-A nrPDB                                                          245   2e-65
3COM-A nrPDB                                                          245   2e-65
4L42-A nrPDB                                                          245   3e-65
4JXF-A nrPDB                                                          244   4e-65
2I6L-A nrPDB                                                          244   4e-65
1VZO-A nrPDB                                                          244   4e-65
3TXO-A nrPDB                                                          244   5e-65
4D2V-A nrPDB                                                          244   5e-65
2UV2-A nrPDB                                                          244   7e-65
4CQG-A nrPDB                                                          243   7e-65
4RLP-A nrPDB                                                          243   1e-64
6FD3-A nrPDB                                                          243   1e-64
1NY3-A nrPDB                                                          243   1e-64
4CZT-A nrPDB                                                          242   2e-64
5D7A-A nrPDB                                                          242   2e-64
2OZA-A nrPDB                                                          242   2e-64
3KA0-A nrPDB                                                          241   3e-64
6CKI-A nrPDB                                                          241   4e-64
5N23-A nrPDB                                                          241   4e-64
4RA4-A nrPDB                                                          241   6e-64
3A8W-A nrPDB                                                          240   1e-63
6CMJ-A nrPDB                                                          239   1e-63
5X8I-B nrPDB                                                          239   1e-63
4WB7-A nrPDB                                                          239   1e-63
2Z7Q-A nrPDB                                                          239   2e-63
5X3F-B nrPDB                                                          239   2e-63
3FXW-A nrPDB                                                          239   2e-63
6FDY-U nrPDB                                                          238   3e-63
4LG4-A nrPDB                                                          236   9e-63
3DAK-A nrPDB                                                          236   1e-62
6HXF-B nrPDB                                                          236   1e-62
4AW2-A nrPDB                                                          235   2e-62
3TKU-A nrPDB                                                          235   2e-62
6FYV-A nrPDB                                                          235   3e-62
3ORZ-A nrPDB                                                          235   3e-62
6AO5-A nrPDB                                                          235   3e-62
3LM0-A nrPDB                                                          233   1e-61
5YV8-A nrPDB                                                          232   1e-61
5J5T-A nrPDB                                                          232   2e-61
3NYO-A nrPDB                                                          232   2e-61
4TNB-A nrPDB                                                          232   2e-61
4I6B-A nrPDB                                                          232   2e-61
4KS7-A nrPDB                                                          232   3e-61
3Q53-A nrPDB                                                          231   3e-61
4YNZ-A nrPDB                                                          231   3e-61
6BDL-A nrPDB                                                          231   4e-61
2F57-A nrPDB                                                          230   6e-61
5LOH-A nrPDB                                                          230   7e-61
3DB8-A nrPDB                                                          230   8e-61
4B6L-A nrPDB                                                          230   1e-60
3RAW-A nrPDB                                                          230   1e-60
3PFQ-A nrPDB                                                          229   1e-60
5DYK-A nrPDB                                                          229   1e-60
6E9W-A nrPDB                                                          229   2e-60
5DBX-A nrPDB                                                          228   3e-60
6ED6-A nrPDB                                                          228   3e-60
3HKO-A nrPDB                                                          228   4e-60
5UNP-A nrPDB                                                          227   4e-60
2X7G-A nrPDB                                                          227   5e-60
2I0E-A nrPDB                                                          227   8e-60
4JDH-A nrPDB                                                          226   1e-59
4FIE-A nrPDB                                                          226   1e-59
4XBR-A nrPDB                                                          225   3e-59
1TKI-A nrPDB                                                          224   4e-59
2Q0N-A nrPDB                                                          224   4e-59
4C0T-A nrPDB                                                          224   4e-59
4U41-A nrPDB                                                          223   1e-58
4QMW-A nrPDB                                                          222   2e-58
4CRL-A nrPDB                                                          222   2e-58
2XIK-A nrPDB                                                          222   2e-58
5FET-A nrPDB                                                          222   2e-58
3VN9-A nrPDB                                                          222   2e-58
4WNO-A nrPDB                                                          221   4e-58
2OU7-A nrPDB                                                          221   4e-58
4WUA-A nrPDB                                                          221   4e-58
4J52-A nrPDB                                                          221   4e-58
4B8L-A nrPDB                                                          221   4e-58
2WO6-A nrPDB                                                          221   4e-58
6E2O-A nrPDB                                                          221   6e-58
3C51-A nrPDB                                                          220   8e-58
6QAU-A nrPDB                                                          220   1e-57
4AF3-A nrPDB                                                          219   1e-57
4FZF-B nrPDB                                                          218   3e-57
6CQF-A nrPDB                                                          217   4e-57
4FR4-A nrPDB                                                          217   5e-57
2VD5-A nrPDB                                                          217   5e-57
4OTD-A nrPDB                                                          217   6e-57
5UUU-A nrPDB                                                          217   8e-57
3PVW-A nrPDB                                                          216   2e-56
2BRG-A nrPDB                                                          215   3e-56
3ALO-A nrPDB                                                          213   9e-56
6CCF-A nrPDB                                                          213   1e-55
4APC-A nrPDB                                                          212   2e-55
2JD5-A nrPDB                                                          212   2e-55
3FME-A nrPDB                                                          211   3e-55
4CSV-A nrPDB                                                          211   4e-55
6BXI-A nrPDB                                                          211   4e-55
5TQX-A nrPDB                                                          211   5e-55
1U5R-A nrPDB                                                          211   5e-55
2GCD-A nrPDB                                                          210   7e-55
3M42-A nrPDB                                                          209   2e-54
4OLI-A nrPDB                                                          209   2e-54
4F9B-A nrPDB                                                          209   2e-54
4CRS-A nrPDB                                                          209   2e-54
4KIK-B nrPDB                                                          208   3e-54
4YHJ-A nrPDB                                                          208   3e-54
6DBM-A nrPDB                                                          206   1e-53
3EQC-A nrPDB                                                          206   1e-53
3QA8-A nrPDB                                                          206   1e-53
5KKR-C nrPDB                                                          206   1e-53
2XNP-A nrPDB                                                          206   1e-53
2WQN-A nrPDB                                                          206   2e-53
4E20-A nrPDB                                                          204   5e-53
4PWN-A nrPDB                                                          203   1e-52
5O2C-A nrPDB                                                          201   4e-52
5O2B-A nrPDB                                                          201   4e-52
6GQK-A nrPDB                                                          200   9e-52
5X02-A nrPDB                                                          200   1e-51
1ZXE-A nrPDB                                                          200   1e-51
5O0Y-A nrPDB                                                          199   1e-51
4GS6-A nrPDB                                                          199   2e-51
6DBN-A nrPDB                                                          197   5e-51
5HI2-A nrPDB                                                          197   8e-51
2DQ7-X nrPDB                                                          197   1e-50
2OGV-A nrPDB                                                          196   1e-50
3A4O-X nrPDB                                                          196   1e-50
2H8H-A nrPDB                                                          196   2e-50
3BEA-A nrPDB                                                          196   2e-50
4AN9-A nrPDB                                                          196   2e-50
6F3F-A nrPDB                                                          195   2e-50
6GVJ-A nrPDB                                                          195   2e-50
2WTK-C nrPDB                                                          195   2e-50
3KRL-A nrPDB                                                          195   3e-50
3DLS-A nrPDB                                                          195   3e-50
4XUF-A nrPDB                                                          195   3e-50
3G0E-A nrPDB                                                          194   4e-50
3CJF-A nrPDB                                                          194   5e-50
5H2U-A nrPDB                                                          194   5e-50
2XYN-A nrPDB                                                          194   6e-50
3HMP-A nrPDB                                                          194   7e-50
1S9I-A nrPDB                                                          194   7e-50
5SYS-A nrPDB                                                          194   7e-50
3OMV-A nrPDB                                                          194   7e-50
2VWV-A nrPDB                                                          193   9e-50
3BGP-A nrPDB                                                          193   1e-49
3IO7-A nrPDB                                                          193   1e-49
2R2P-A nrPDB                                                          193   1e-49
5AP3-A nrPDB                                                          192   2e-49
4EQM-A nrPDB                                                          192   2e-49
4RC3-A nrPDB                                                          192   2e-49
4IAN-A nrPDB                                                          192   2e-49
2ZMD-A nrPDB                                                          192   3e-49
4XEY-B nrPDB                                                          192   3e-49
5HIE-A nrPDB                                                          192   3e-49
5TUR-A nrPDB                                                          192   3e-49
2PL0-A nrPDB                                                          192   3e-49
4R7H-A nrPDB                                                          191   3e-49
4UY9-A nrPDB                                                          191   6e-49
4EBW-A nrPDB                                                          190   8e-49
2W1I-A nrPDB                                                          190   8e-49
2FO0-A nrPDB                                                          190   9e-49
3LLT-A nrPDB                                                          190   9e-49
6NPU-A nrPDB                                                          190   9e-49
4E93-A nrPDB                                                          189   1e-48
3PPZ-A nrPDB                                                          189   1e-48
3DTC-A nrPDB                                                          189   2e-48
4H1J-A nrPDB                                                          189   2e-48
2J0K-A nrPDB                                                          189   2e-48
4X7Q-B nrPDB                                                          189   3e-48
3TT0-A nrPDB                                                          189   3e-48
3PP0-A nrPDB                                                          188   4e-48
4AT3-A nrPDB                                                          188   4e-48
4C59-A nrPDB                                                          188   4e-48
3BBT-B nrPDB                                                          187   5e-48
5A46-A nrPDB                                                          187   7e-48
3GQL-A nrPDB                                                          187   7e-48
3ORP-A nrPDB                                                          187   7e-48
4UYA-A nrPDB                                                          187   8e-48
2HK5-A nrPDB                                                          187   8e-48
4P5Q-A nrPDB                                                          187   9e-48
1FVR-A nrPDB                                                          187   9e-48
3C1X-A nrPDB                                                          186   1e-47
6HV0-A nrPDB                                                          185   2e-47
5GRN-A nrPDB                                                          185   2e-47
4JLC-A nrPDB                                                          185   3e-47
5HLW-A nrPDB                                                          185   3e-47
4PL5-B nrPDB                                                          185   3e-47
2A1A-B nrPDB                                                          184   5e-47
4HVI-A nrPDB                                                          184   5e-47
1AD5-A nrPDB                                                          184   6e-47
5X5O-A nrPDB                                                          184   8e-47
2PMN-X nrPDB                                                          184   9e-47
4EUT-A nrPDB                                                          183   1e-46
2RIO-A nrPDB                                                          182   2e-46
5B2L-A nrPDB                                                          182   2e-46
4EUU-A nrPDB                                                          182   3e-46
2PSQ-A nrPDB                                                          182   3e-46
6O8B-A nrPDB                                                          181   4e-46
6NT9-A nrPDB                                                          181   4e-46
4K33-A nrPDB                                                          180   1e-45
5EG3-A nrPDB                                                          179   2e-45
3KUL-B nrPDB                                                          179   2e-45
4XCU-A nrPDB                                                          179   3e-45
4M7I-A nrPDB                                                          178   5e-45
4XLV-A nrPDB                                                          178   5e-45
4IDT-A nrPDB                                                          177   5e-45
3UIU-A nrPDB                                                          177   6e-45
6CTH-A nrPDB                                                          177   7e-45
4Y83-A nrPDB                                                          177   8e-45
2WTK-B nrPDB                                                          176   2e-44
4LRM-A nrPDB                                                          175   2e-44
5GNK-A nrPDB                                                          175   4e-44
4G3E-A nrPDB                                                          174   8e-44
6B2Q-A nrPDB                                                          173   1e-43
4X3F-A nrPDB                                                          173   1e-43
4OW8-A nrPDB                                                          173   1e-43
3LZB-A nrPDB                                                          173   1e-43
2BUJ-A nrPDB                                                          172   3e-43
5TE0-A nrPDB                                                          172   3e-43
5AMN-A nrPDB                                                          172   3e-43
5HVK-A nrPDB                                                          171   5e-43
5U6B-A nrPDB                                                          169   1e-42
3PLS-A nrPDB                                                          169   2e-42
5VD3-A nrPDB                                                          167   5e-42
3QUP-A nrPDB                                                          167   6e-42
4TPT-A nrPDB                                                          167   1e-41
5FM2-A nrPDB                                                          166   2e-41
5IKW-A nrPDB                                                          165   3e-41
3ZZW-A nrPDB                                                          164   8e-41
3MDY-A nrPDB                                                          162   2e-40
6DC0-A nrPDB                                                          159   1e-39
5CEK-A nrPDB                                                          159   2e-39
4NEU-A nrPDB                                                          157   6e-39
4M66-A nrPDB                                                          156   2e-38
5L2Q-C nrPDB                                                          155   2e-38
4LQP-A nrPDB                                                          155   3e-38
3MY0-A nrPDB                                                          155   4e-38
5WNL-A nrPDB                                                          151   4e-37
2H34-A nrPDB                                                          149   2e-36
3QD2-B nrPDB                                                          147   5e-36
4TN6-A nrPDB                                                          142   4e-34
3SV0-A nrPDB                                                          140   7e-34
2CHL-A nrPDB                                                          140   8e-34
5AR8-A nrPDB                                                          140   1e-33
4BTK-A nrPDB                                                          138   4e-33
5FQD-C nrPDB                                                          137   6e-33
4NFN-A nrPDB                                                          137   8e-33
2C47-A nrPDB                                                          136   2e-32
2QLU-A nrPDB                                                          135   2e-32
5X18-A nrPDB                                                          135   3e-32
2CMW-A nrPDB                                                          133   9e-32
4NT4-A nrPDB                                                          133   1e-31
2PZI-A nrPDB                                                          131   6e-31
4Y12-A nrPDB                                                          130   7e-31
3HNG-A nrPDB                                                          129   3e-30
4RT7-A nrPDB                                                          128   4e-30
3VHK-A nrPDB                                                          126   1e-29
1CSN-A nrPDB                                                          123   8e-29
5M07-A nrPDB                                                          122   3e-28
4XHH-A nrPDB                                                          120   8e-28
4XHL-A nrPDB                                                          117   7e-27
4IX6-A nrPDB                                                           78   6e-15

Sequences not found previously or not previously below threshold:

3DKO-A nrPDB                                                          191   5e-49
3V5Q-A nrPDB                                                          190   6e-49
1JPA-A nrPDB                                                          187   9e-48
5MJB-A nrPDB                                                          185   2e-47
2Y6O-A nrPDB                                                          185   3e-47
5L6P-A nrPDB                                                          185   3e-47
4PDO-A nrPDB                                                          183   1e-46
5KMM-A nrPDB                                                          183   1e-46
3QGY-A nrPDB                                                          182   3e-46
5VO2-A nrPDB                                                          181   6e-46
6FEX-A nrPDB                                                          180   7e-46
6BSD-A nrPDB                                                          178   3e-45
6E4F-A nrPDB                                                          177   5e-45
3SXS-A nrPDB                                                          177   7e-45
4XI2-A nrPDB                                                          176   1e-44
1LUF-A nrPDB                                                          175   2e-44
1U59-A nrPDB                                                          174   6e-44
4Y93-A nrPDB                                                          173   9e-44
3ZBF-A nrPDB                                                          173   1e-43
2OZO-A nrPDB                                                          172   3e-43
1K9A-A nrPDB                                                          170   9e-43
4YFF-A nrPDB                                                          169   2e-42
1BYG-A nrPDB                                                          167   5e-42
6FER-A nrPDB                                                          167   6e-42
3I81-A nrPDB                                                          165   2e-41
4HZS-A nrPDB                                                          165   3e-41
5U6C-A nrPDB                                                          164   5e-41
1U54-B nrPDB                                                          164   9e-41
5UIU-A nrPDB                                                          160   9e-40
3Q4U-A nrPDB                                                          157   7e-39
5TOS-A nrPDB                                                          155   3e-38
1PY5-A nrPDB                                                          152   2e-37
3AOX-A nrPDB                                                          152   2e-37
4F0G-A nrPDB                                                          152   3e-37
3UIM-A nrPDB                                                          151   4e-37
6J5U-C nrPDB                                                          151   5e-37
3G2F-A nrPDB                                                          150   7e-37
5LPZ-A nrPDB                                                          150   1e-36
5C26-A nrPDB                                                          150   1e-36
4FL3-A nrPDB                                                          150   1e-36
5LPV-A nrPDB                                                          149   2e-36
3LMG-A nrPDB                                                          146   1e-35
5WNO-A nrPDB                                                          145   2e-35
3SOC-A nrPDB                                                          144   5e-35
5XD6-A nrPDB                                                          140   1e-33
2Y4I-B nrPDB                                                          139   2e-33
2QKW-B nrPDB                                                          138   3e-33
5E8V-A nrPDB                                                          138   3e-33
5VC6-A nrPDB                                                          134   5e-32
5J0A-A nrPDB                                                          134   7e-32
5VDK-A nrPDB                                                          131   5e-31
6BFN-A nrPDB                                                          120   2e-27
4MWI-A nrPDB                                                          112   3e-25
5UV4-A nrPDB                                                          112   4e-25
4BTF-A nrPDB                                                          106   2e-23
4M69-B nrPDB                                                          105   2e-23
4JRN-A nrPDB                                                          104   7e-23
4L00-A nrPDB                                                          103   1e-22
5USZ-A nrPDB                                                          103   1e-22
5X1R-A nrPDB                                                          103   2e-22
5OAT-A nrPDB                                                           97   2e-20
6EQI-C nrPDB                                                           96   3e-20
3REP-A nrPDB                                                           92   3e-19
5CLR-A nrPDB                                                           90   2e-18
6J6I-B nrPDB                                                           89   4e-18
5DMZ-A nrPDB                                                           85   4e-17
4L68-A nrPDB                                                           84   1e-16
5C01-A nrPDB                                                           84   1e-16
5UU1-A nrPDB                                                           84   2e-16
4CI6-B nrPDB                                                           83   2e-16
4WOV-A nrPDB                                                           83   3e-16
6G4J-A nrPDB                                                           82   5e-16
4I94-A nrPDB                                                           80   1e-15
2RSV-A nrPDB                                                           79   3e-15
2LAV-A nrPDB                                                           78   6e-15
4O1O-A nrPDB                                                           69   3e-12
2JII-A nrPDB                                                           64   1e-10
4OAU-C nrPDB                                                           63   2e-10
4CYJ-A nrPDB                                                           58   9e-09
6EWX-A nrPDB                                                           58   9e-09
5GZA-A nrPDB                                                           57   2e-08
5GZ9-A nrPDB                                                           56   2e-08
4AZW-A nrPDB                                                           53   3e-07
6M7Z-A nrPDB                                                           53   3e-07
6EAS-A nrPDB                                                           52   4e-07
4AZV-A nrPDB                                                           52   4e-07
6BHC-A nrPDB                                                           49   3e-06
5VE6-A nrPDB                                                           49   3e-06
3ENH-A nrPDB                                                           49   3e-06
1TQM-A nrPDB                                                           48   5e-06
6G38-A nrPDB                                                           48   5e-06
4WWA-A nrPDB                                                           45   4e-05
4CZY-B nrPDB                                                           45   6e-05
2W1Z-A nrPDB                                                           43   2e-04
3BYV-A nrPDB                                                           43   3e-04
3DZO-A nrPDB                                                           41   0.001
4BVU-A nrPDB                                                           40   0.003
3Q60-A nrPDB                                                           39   0.003
5YK0-A nrPDB                                                           38   0.005
4BWP-A nrPDB                                                           37   0.012
6G18-v nrPDB                                                           36   0.028
5I35-A nrPDB                                                           36   0.029
6FDN-A nrPDB                                                           35   0.048
6EF6-A nrPDB                                                           32   0.47 
4BFR-A nrPDB                                                           32   0.50 
4P4S-A nrPDB                                                           31   1.3  
4P4S-B nrPDB                                                           30   1.4  
6DFL-A nrPDB                                                           30   1.4  

>4MD7-E nrPDB
          Length = 391

 Score =  566 bits (1460), Expect = e-162,   Method: Composition-based stats.
 Identities = 387/391 (98%), Positives = 387/391 (98%)

Query: 1   MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINIT 60
           MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINIT
Sbjct: 1   MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINIT 60

Query: 61  NNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTD 120
           NNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTD
Sbjct: 61  NNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTD 120

Query: 121 FKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE 180
           FKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE
Sbjct: 121 FKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE 180

Query: 181 FYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYD 240
           FYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYD
Sbjct: 181 FYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYD 240

Query: 241 QLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDF 300
           QLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDF
Sbjct: 241 QLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDF 300

Query: 301 LDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPT 360
           LDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGS PVSSANMMSGISSVP 
Sbjct: 301 LDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSEPVSSANMMSGISSVPE 360

Query: 361 PSPLGPLAGSPVIAAANPLGMPVPAAAGAQQ 391
           P PLGPLAG PVIAAANPLGMPVPAAAGAQQ
Sbjct: 361 PEPLGPLAGEPVIAAANPLGMPVPAAAGAQQ 391


>6EII-A nrPDB
          Length = 352

 Score =  478 bits (1230), Expect = e-135,   Method: Composition-based stats.
 Identities = 327/328 (99%), Positives = 327/328 (99%)

Query: 2   SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITN 61
           SGPVPSRARVYTDVNTHRP EYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITN
Sbjct: 25  SGPVPSRARVYTDVNTHRPSEYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITN 84

Query: 62  NEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDF 121
           NEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDF
Sbjct: 85  NEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDF 144

Query: 122 KQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF 181
           KQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF
Sbjct: 145 KQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF 204

Query: 182 YHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQ 241
           YHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQ
Sbjct: 205 YHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQ 264

Query: 242 LVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFL 301
           LVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFL
Sbjct: 265 LVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFL 324

Query: 302 DKLLRYDHQSRLTAREAMEHPYFYTVVK 329
           DKLLRYDHQSRLTAREAMEHPYFYTVVK
Sbjct: 325 DKLLRYDHQSRLTAREAMEHPYFYTVVK 352


>6HMD-A nrPDB
          Length = 365

 Score =  412 bits (1058), Expect = e-115,   Method: Composition-based stats.
 Identities = 289/356 (81%), Positives = 314/356 (88%), Gaps = 7/356 (1%)

Query: 1   MSGPVP-SRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINI 59
           M GP   SRARVY +VN+ R REYWDYE+HV  WGNQDDYQLVRKLGRGKYSEVFEAINI
Sbjct: 16  MPGPAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINI 75

Query: 60  TNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNT 119
           TNNE+VVVKILKPVKKKKIKRE+KILENLRGG NII L D VKDPVS+TPALVFE++NNT
Sbjct: 76  TNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNT 135

Query: 120 DFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA 179
           DFKQLYQ LTD+DIRFYMYE+LKALDYCHS GIMHRDVKPHNVMIDH+ +KLRLIDWGLA
Sbjct: 136 DFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLA 195

Query: 180 EFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNY 239
           EFYHP QEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFR+EPFFHG DNY
Sbjct: 196 EFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNY 255

Query: 240 DQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALD 299
           DQLVRIAKVLGTE+LY Y+ KY+I+LDP FNDILG+HSRKRWE F+HSEN+HLVSPEALD
Sbjct: 256 DQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALD 315

Query: 300 FLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGI 355
            LDKLLRYDHQ RLTA+EAMEHPYFY VVK+Q      S P     V S+ + +  
Sbjct: 316 LLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQ------SQPSADNAVLSSGLTAAR 365


>2PVN-A nrPDB
          Length = 352

 Score =  386 bits (992), Expect = e-108,   Method: Composition-based stats.
 Identities = 250/326 (76%), Positives = 286/326 (87%)

Query: 3   GPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNN 62
           G   S+ARVY DVN  RP+EYWDYE+  V+WG QDDY++VRK+GRGKYSEVFE IN+ NN
Sbjct: 18  GSHMSKARVYADVNVLRPKEYWDYEALTVQWGEQDDYEVVRKVGRGKYSEVFEGINVNNN 77

Query: 63  EKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFK 122
           EK ++KILKPVKKKKIKREIKIL+NL GGPNI+ L DIV+D  S+TP+L+FE+VNNTDFK
Sbjct: 78  EKCIIKILKPVKKKKIKREIKILQNLCGGPNIVKLLDIVRDQHSKTPSLIFEYVNNTDFK 137

Query: 123 QLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFY 182
            LY TLTDYDIR+Y+YE+LKALDYCHS GIMHRDVKPHNVMIDHE RKLRLIDWGLAEFY
Sbjct: 138 VLYPTLTDYDIRYYIYELLKALDYCHSQGIMHRDVKPHNVMIDHELRKLRLIDWGLAEFY 197

Query: 183 HPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQL 242
           HPG+EYNVRVASRYFKGPELLVD Q YDYSLDMWSLGCM A MIFRKEPFF+GHDN+DQL
Sbjct: 198 HPGKEYNVRVASRYFKGPELLVDLQDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQL 257

Query: 243 VRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLD 302
           V+IAKVLGT+ L  Y++KY IELDP+   ++GRHSRK W +F++++NQHLVSPEA+DFLD
Sbjct: 258 VKIAKVLGTDGLNAYLNKYRIELDPQLEALVGRHSRKPWLKFMNADNQHLVSPEAIDFLD 317

Query: 303 KLLRYDHQSRLTAREAMEHPYFYTVV 328
           KLLRYDHQ RLTA EAM HPYF  V 
Sbjct: 318 KLLRYDHQERLTALEAMTHPYFQQVR 343


>6O6Q-A nrPDB
          Length = 335

 Score =  386 bits (991), Expect = e-107,   Method: Composition-based stats.
 Identities = 211/324 (65%), Positives = 265/324 (81%), Gaps = 1/324 (0%)

Query: 5   VPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEK 64
           V S +RVY DV + +P+ YWDY+   ++W  Q++Y+++RKLGRGKYSEVF  I++   EK
Sbjct: 9   VQSVSRVYADVLSTKPQSYWDYDDLNIKWNPQENYEILRKLGRGKYSEVFLGIDLEKREK 68

Query: 65  VVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQL 124
           VV+K+LKPVK+KKIKREI IL+NL  GPNII + D+V++P S+TP L+FEH+NN DF+ L
Sbjct: 69  VVIKVLKPVKRKKIKREISILKNLVDGPNIIAMLDVVREPQSKTPGLIFEHINNIDFRSL 128

Query: 125 YQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHP 184
           Y T TDYDIRFYMYE+LKALDY HSMGIMHRDVKPHNVMIDH+ + LRLIDWGLAE+YHP
Sbjct: 129 YPTFTDYDIRFYMYELLKALDYSHSMGIMHRDVKPHNVMIDHDKKLLRLIDWGLAEYYHP 188

Query: 185 GQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVR 244
           G EYNVRVASRYFKGPELLVDY++YDYSLDMWS GCMLASM+F KEPFFHG  N DQLV+
Sbjct: 189 GTEYNVRVASRYFKGPELLVDYRLYDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQLVQ 248

Query: 245 IAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKL 304
           I +VLG+++   Y++KYNI L   + DI G +++++W RF++  N+ LVS E LD +D+L
Sbjct: 249 IVRVLGSKNFKKYLEKYNISLGEEYEDI-GYYNKRQWVRFMNENNKDLVSQEFLDLIDRL 307

Query: 305 LRYDHQSRLTAREAMEHPYFYTVV 328
           LRYDHQ RLTA+EAM+H YF  + 
Sbjct: 308 LRYDHQERLTAKEAMKHAYFDPIR 331


>5XVU-A nrPDB
          Length = 332

 Score =  365 bits (937), Expect = e-101,   Method: Composition-based stats.
 Identities = 209/323 (64%), Positives = 261/323 (80%)

Query: 10  RVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKI 69
           + Y DVN H+P+EY+DY++  ++W   + Y++++K+GRGKYSEVF   +   N    +K+
Sbjct: 4   KFYADVNIHKPKEYYDYDNLELQWNKPNRYEIMKKIGRGKYSEVFNGYDTECNRPCAIKV 63

Query: 70  LKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLT 129
           LKPVKKKKIKREIKIL+NL GGPNII L DIVKDPV++TP+L+FE++NN DFK LY   T
Sbjct: 64  LKPVKKKKIKREIKILQNLNGGPNIIKLLDIVKDPVTKTPSLIFEYINNIDFKTLYPKFT 123

Query: 130 DYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYN 189
           D DIR+Y+Y+ILKALDYCHS GIMHRDVKPHN+MIDHE+R++RLI WGLAEFYHPGQEYN
Sbjct: 124 DKDIRYYIYQILKALDYCHSQGIMHRDVKPHNIMIDHENRQIRLISWGLAEFYHPGQEYN 183

Query: 190 VRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVL 249
           VRVASRY+KGPELL+D Q+YDYSLD+WSLGCMLA MIF+KEPFF GHDNYDQLV+IAKVL
Sbjct: 184 VRVASRYYKGPELLIDLQLYDYSLDIWSLGCMLAGMIFKKEPFFCGHDNYDQLVKIAKVL 243

Query: 250 GTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDH 309
           GTEDL+ Y+ KYNI+L P + +ILG + RK W  F+   N  +   E +D +DK+L YDH
Sbjct: 244 GTEDLHAYLKKYNIKLKPHYLNILGEYERKPWSHFLTQSNIDIAKDEVIDLIDKMLIYDH 303

Query: 310 QSRLTAREAMEHPYFYTVVKDQA 332
             R+  +EAMEHPYF  V ++ A
Sbjct: 304 AKRIAPKEAMEHPYFREVREESA 326


>4LFI-A nrPDB
          Length = 374

 Score =  329 bits (844), Expect = 1e-90,   Method: Composition-based stats.
 Identities = 201/374 (53%), Positives = 257/374 (68%), Gaps = 43/374 (11%)

Query: 1   MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWG-NQDDYQLVRKLGRGKYSEVFEAINI 59
           M   V S ARVYT++N  R  EYWDYE+ V++W  N  DY++  K+GRGKYSEVF+ + +
Sbjct: 3   MKCRVWSEARVYTNINKQRTEEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKL 62

Query: 60  TNNEKVVVKI---------------LKPVKKKKI---------------KREIKILENLR 89
            +  K+V+K+               L  +  +K+               ++E  +L+ +R
Sbjct: 63  DSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKE-DVLKFIR 121

Query: 90  ---------GGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEI 140
                    G  NII L DI+KDP+S+TPALVFE+V+N DF+ LY  LTD +IRFYM+E+
Sbjct: 122 PYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPKLTDLEIRFYMFEL 181

Query: 141 LKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGP 200
           LKALDYCHSMGIMHRDVKPHNVMIDH+++KLRLIDWGLAEFYH   EYNVRVASR+FKGP
Sbjct: 182 LKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGP 241

Query: 201 ELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDK 260
           ELLVDY+MYDYSLD+WS G MLASMIF++EPFFHG  N DQLV+I KVLGT D   Y+ K
Sbjct: 242 ELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLK 301

Query: 261 YNIELDPRFNDILGRHSRKRWERFVHSENQHL-VSPEALDFLDKLLRYDHQSRLTAREAM 319
           Y I L   F D+  ++ RK W RF++  N+HL  + E +D +D LLRYDHQ RLTA+EAM
Sbjct: 302 YEITLPREFYDM-DQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAM 360

Query: 320 EHPYFYTVVKDQAR 333
            HP+F  + +   +
Sbjct: 361 GHPWFAPIREQIEK 374


>5JN2-A nrPDB
          Length = 525

 Score =  308 bits (790), Expect = 2e-84,   Method: Composition-based stats.
 Identities = 80/339 (23%), Positives = 148/339 (43%), Gaps = 53/339 (15%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP------VKKKKIKREIKILENLRG 90
           D Y+  R LG+G + EV    +    ++  VK++          K+ + RE+++L+ L  
Sbjct: 67  DRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQL-D 125

Query: 91  GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYC 147
            PNI+ L +  +D       LV E     +        +  ++ D    + ++L  + Y 
Sbjct: 126 HPNIMKLYEFFEDKG--YFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYM 183

Query: 148 HSMGIMHRDVKPHNVMIDHEHR--KLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVD 205
           H   I+HRD+KP N++++ + +   +R+ID+GL+  +   ++   ++ + Y+  PE+L  
Sbjct: 184 HKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVL-- 241

Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIEL 265
           +  YD   D+WS G +L  ++    PF +G + YD L ++ K            KY  EL
Sbjct: 242 HGTYDEKCDVWSTGVILYILLSGCPPF-NGANEYDILKKVEK-----------GKYTFEL 289

Query: 266 DPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFY 325
                                      VS  A D + K+L Y    R++AR+A++H +  
Sbjct: 290 P----------------------QWKKVSESAKDLIRKMLTYVPSMRISARDALDHEWIQ 327

Query: 326 TVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPL 364
           T  K+Q    S  +P     + +     G   +   + L
Sbjct: 328 TYTKEQI---SVDVPSLDNAILNIRQFQGTQKLAQAALL 363


>3NCG-A nrPDB
          Length = 486

 Score =  306 bits (785), Expect = 7e-84,   Method: Composition-based stats.
 Identities = 80/342 (23%), Positives = 147/342 (42%), Gaps = 57/342 (16%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL-----KPVKKKKIKREIKILENLRGG 91
           + Y +V  LG+G + EV +  +    ++  VK++     K      I RE+++L+ L   
Sbjct: 22  ERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKL-DH 80

Query: 92  PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCH 148
           PNI+ L +I++D  S +  +V E     +        +  +++D    + ++   + Y H
Sbjct: 81  PNIMKLFEILED--SSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMH 138

Query: 149 SMGIMHRDVKPHNVMIDHEHRK--LRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDY 206
              I+HRD+KP N++++ + +   +++ID+GL+  +    +   R+ + Y+  PE+L   
Sbjct: 139 KHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVL--R 196

Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 266
             YD   D+WS G +L  ++    PF+ G + YD L R+              KY  +L 
Sbjct: 197 GTYDEKCDVWSAGVILYILLSGTPPFY-GKNEYDILKRVE-----------TGKYAFDLP 244

Query: 267 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYT 326
                                     +S +A D + K+L +    R+TA + +EHP+   
Sbjct: 245 ----------------------QWRTISDDAKDLIRKMLTFHPSLRITATQCLEHPWIQK 282

Query: 327 VVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLGPLA 368
                    SS  P  S   S  + M+ I        L   A
Sbjct: 283 Y--------SSETPTISDLPSLESAMTNIRQFQAEKKLAQAA 316


>5Z33-A nrPDB
          Length = 425

 Score =  305 bits (782), Expect = 2e-83,   Method: Composition-based stats.
 Identities = 102/382 (26%), Positives = 189/382 (49%), Gaps = 30/382 (7%)

Query: 30  VVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL-----KPVKKKKIKREIKI 84
             ++   + Y + ++LG+G Y  V  A+N   +E V +K +     K +  K+  REIK+
Sbjct: 24  NQDFIVDERYTVTKELGQGAYGIVCAAVNNQTSEGVAIKKVTNVFSKKILAKRALREIKL 83

Query: 85  LENLRGGPNIITLADI-VKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEI 140
           L++ RG  NI  L D+ +  P +     ++E +   D   + ++   LTD   + ++Y+I
Sbjct: 84  LQHFRGHRNITCLYDMDIPRPDNFNETYLYEELMECDLAAIIRSGQPLTDAHFQSFIYQI 143

Query: 141 LKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE-----YNVRVASR 195
           L  L Y HS  ++HRD+KP N++++ +  +L++ D+GLA  +    E         VA+R
Sbjct: 144 LCGLKYIHSANVLHRDLKPGNLLVNADC-ELKICDFGLARGFSVDPEENAGYMTEYVATR 202

Query: 196 YFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLY 255
           +++ PE+++ +Q Y  ++D+WS+GC+LA ++    PFF G D  DQL +I  +LGT +  
Sbjct: 203 WYRAPEIMLSFQSYTKAIDVWSVGCILAELL-GGRPFFKGRDYVDQLNQILHILGTPN-E 260

Query: 256 DYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTA 315
           + + +        +   L   ++K +     + N     P+ALD LD++L +D  SR++ 
Sbjct: 261 ETLSRIGSPRAQEYVRNLPFMAKKPFPTLFPNAN-----PDALDLLDRMLAFDPSSRISV 315

Query: 316 REAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSV------PTPSPLGPLAG 369
            +A+EHPY +  +   A          +        +  +  +           +    G
Sbjct: 316 EQALEHPYLH--IWHDASDEPDCPTTFNFDFEVVEDVGEMRKMILDEVYRFRQLVRTAPG 373

Query: 370 SPVIAAANPLGMPVPAAAGAQQ 391
           +    A +   +P+PA AG  Q
Sbjct: 374 AGGHGAPHAPQVPIPAGAGQGQ 395


>2BPM-A nrPDB
          Length = 309

 Score =  303 bits (776), Expect = 9e-83,   Method: Composition-based stats.
 Identities = 90/306 (29%), Positives = 160/306 (52%), Gaps = 25/306 (8%)

Query: 35  NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK-----KKIKREIKILENLR 89
           + +++Q V K+G G Y  V++A N    E V +K ++   +         REI +L+ L 
Sbjct: 5   DMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKEL- 63

Query: 90  GGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT-----LTDYDIRFYMYEILKAL 144
             PNI+ L D++         LVFE + + D K+         +    I+ Y++++L+ L
Sbjct: 64  NHPNIVKLLDVIH--TENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGL 120

Query: 145 DYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH-PGQEYNVRVASRYFKGPELL 203
            +CHS  ++HRD+KP N++I+ E   ++L D+GLA  +  P + Y   V + +++ PE+L
Sbjct: 121 AFCHSHRVLHRDLKPQNLLINTEG-AIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEIL 179

Query: 204 VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNI 263
           +  + Y  ++D+WSLGC+ A M+ R+   F G    DQL RI + LGT D   +    ++
Sbjct: 180 LGCKYYSTAVDIWSLGCIFAEMVTRRA-LFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSM 238

Query: 264 ELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323
              P +     + +R+ + + V       +  +    L ++L YD   R++A+ A+ HP+
Sbjct: 239 ---PDYKPSFPKWARQDFSKVVPP-----LDEDGRSLLSQMLHYDPNKRISAKAALAHPF 290

Query: 324 FYTVVK 329
           F  V K
Sbjct: 291 FQDVTK 296


>4EWQ-A nrPDB
          Length = 383

 Score =  300 bits (769), Expect = 6e-82,   Method: Composition-based stats.
 Identities = 90/327 (27%), Positives = 168/327 (51%), Gaps = 22/327 (6%)

Query: 11  VYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL 70
             ++ +  RP  ++  E +   W   + YQ +  +G G Y  V  A +     +V VK L
Sbjct: 20  FQSNASQERPT-FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKL 78

Query: 71  KP-----VKKKKIKREIKILENLRGGPNIITLADIV---KDPVSRTPALVFEHVNNTDFK 122
                  +  K+  RE+++L++++   N+I L D+    +         +  H+   D  
Sbjct: 79  SRPFQSIIHAKRTYRELRLLKHMKH-ENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLN 137

Query: 123 QL--YQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE 180
            +   Q LTD  ++F +Y+IL+ L Y HS  I+HRD+KP N+ ++ +  +L+++D+GLA 
Sbjct: 138 NIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDC-ELKILDFGLAR 196

Query: 181 FYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYD 240
             H   E    VA+R+++ PE+++++  Y+ ++D+WS+GC++A ++  +   F G D+ D
Sbjct: 197 --HTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRT-LFPGTDHID 253

Query: 241 QLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDF 300
           QL  I +++GT    + + K + E    +   L +  +  +       N     P A+D 
Sbjct: 254 QLKLILRLVGTPGA-ELLKKISSESARNYIQSLTQMPKMNFANVFIGAN-----PLAVDL 307

Query: 301 LDKLLRYDHQSRLTAREAMEHPYFYTV 327
           L+K+L  D   R+TA +A+ H YF   
Sbjct: 308 LEKMLVLDSDKRITAAQALAHAYFAQY 334


>3OHT-A nrPDB
          Length = 389

 Score =  299 bits (767), Expect = 1e-81,   Method: Composition-based stats.
 Identities = 95/332 (28%), Positives = 173/332 (52%), Gaps = 24/332 (7%)

Query: 7   SRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVV 66
           S A  +T  +  RP  ++  E +   W   + YQ +  +G G Y  V  + ++ +  K+ 
Sbjct: 22  SAAAPFTMSHKERPT-FYRQELNKTIWEVPERYQTLSPVGSGAYGSVCSSYDVKSGLKIA 80

Query: 67  VKILKP-----VKKKKIKREIKILENLRGGPNIITLADIVKDPVS----RTPALVFEHVN 117
           VK L       +  K+  RE+++L++++   N+I L D+     S        LV  H+ 
Sbjct: 81  VKKLSRPFQSIIHAKRTYRELRLLKHMKH-ENVIGLLDVFTPATSLEEFNDVYLVT-HLM 138

Query: 118 NTDFKQL--YQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLID 175
             D   +   Q LTD  ++F +Y+IL+ L Y HS  I+HRD+KP N+ ++ +  +L+++D
Sbjct: 139 GADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDC-ELKILD 197

Query: 176 WGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHG 235
           +GLA   H   E    VA+R+++ PE+++++  Y+ ++D+WS+GC++A ++  +   F G
Sbjct: 198 FGLAR--HTDDEMTGYVATRWYRAPEIMLNWMHYNMTVDIWSVGCIMAELLTGRT-LFPG 254

Query: 236 HDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSP 295
            D+ +QL +I ++ GT          + E    + + L +  ++ +       N     P
Sbjct: 255 TDHINQLQQIMRLTGTPPASVISRMPSHEAR-NYINSLPQMPKRNFADVFIGAN-----P 308

Query: 296 EALDFLDKLLRYDHQSRLTAREAMEHPYFYTV 327
            A+D L+K+L  D   R+TA EA+ HPYF   
Sbjct: 309 LAVDLLEKMLVLDTDKRITASEALAHPYFSQY 340


>5AIR-A nrPDB
          Length = 430

 Score =  299 bits (765), Expect = 2e-81,   Method: Composition-based stats.
 Identities = 111/367 (30%), Positives = 173/367 (47%), Gaps = 42/367 (11%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIK-REIKILENLRGGPNIITL 97
           Y   + +G G +  V++A    + E V +K  K ++ K+ K RE++I+  L    NI+ L
Sbjct: 66  YTDTKVIGNGSFGVVYQAKLCDSGELVAIK--KVLQDKRFKNRELQIMRKLDHC-NIVRL 122

Query: 98  ADIVKDPVSR----TPALVFEHVNNTDFK------QLYQTLTDYDIRFYMYEILKALDYC 147
                    +       LV ++V  T ++      +  QTL    ++ YMY++ ++L Y 
Sbjct: 123 RYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYI 182

Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQ 207
           HS GI HRD+KP N+++D +   L+L D+G A+    G+     + SRY++ PEL+    
Sbjct: 183 HSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGAT 242

Query: 208 MYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDP 267
            Y  S+D+WS GC+LA ++  + P F G    DQLV I KVLGT            E++P
Sbjct: 243 DYTSSIDVWSAGCVLAELLLGQ-PIFPGDSGVDQLVEIIKVLGTPTREQI-----REMNP 296

Query: 268 RFNDI-LGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYT 326
            + +    +     W +           PEA+    +LL Y   +RLT  EA  H +F  
Sbjct: 297 NYTEFKFPQIKAHPWTKVFRPRTP----PEAIALCSRLLEYTPTARLTPLEACAHSFF-- 350

Query: 327 VVKDQARMGSSSMPGG-STPVSSANMMSGISSVPTPSPLGPLAGSP---VIAAANPLGMP 382
              D+ R  +  +P G  TP         +SS P   PL  +   P   + AAA+P    
Sbjct: 351 ---DELRDPNVKLPNGRDTPALFNFTTQELSSNP---PLATILIPPHARIQAAASP---- 400

Query: 383 VPAAAGA 389
            PA A A
Sbjct: 401 -PANATA 406


>3NIZ-A nrPDB
          Length = 311

 Score =  299 bits (765), Expect = 2e-81,   Method: Composition-based stats.
 Identities = 94/307 (30%), Positives = 161/307 (52%), Gaps = 24/307 (7%)

Query: 34  GNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK-----IKREIKILENL 88
           G  + YQ + K+G G Y  V++A + +    V +K ++   + +       REI +L+ L
Sbjct: 18  GLMEKYQKLEKVGEGTYGVVYKAKD-SQGRIVALKRIRLDAEDEGIPSTAIREISLLKEL 76

Query: 89  RGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----LTDYDIRFYMYEILKAL 144
              PNI++L D++     R   LVFE +   D K++       L D  I+ Y+Y++L+ +
Sbjct: 77  -HHPNIVSLIDVIHS--ERCLTLVFEFMEK-DLKKVLDENKTGLQDSQIKIYLYQLLRGV 132

Query: 145 DYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH-PGQEYNVRVASRYFKGPELL 203
            +CH   I+HRD+KP N++I+ +   L+L D+GLA  +  P + Y   V + +++ P++L
Sbjct: 133 AHCHQHRILHRDLKPQNLLINSDG-ALKLADFGLARAFGIPVRSYTHEVVTLWYRAPDVL 191

Query: 204 VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNI 263
           +  + Y  S+D+WS+GC+ A MI  K P F G  + DQL +I  +LGT +  ++     +
Sbjct: 192 MGSKKYSTSVDIWSIGCIFAEMITGK-PLFPGVTDDDQLPKIFSILGTPNPREWPQVQEL 250

Query: 264 ELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323
            L  +         +K W   +    Q     E +D L  +L +D   R++AR+AM HPY
Sbjct: 251 PLWKQ--RTFQVFEKKPWSSIIPGFCQ-----EGIDLLSNMLCFDPNKRISARDAMNHPY 303

Query: 324 FYTVVKD 330
           F  +   
Sbjct: 304 FKDLDPQ 310


>1CM8-A nrPDB
          Length = 367

 Score =  296 bits (759), Expect = 9e-81,   Method: Composition-based stats.
 Identities = 98/338 (28%), Positives = 177/338 (52%), Gaps = 35/338 (10%)

Query: 1   MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINIT 60
           MS P P+R+  Y              E     W  +  Y+ ++ +G G Y  V  A++  
Sbjct: 1   MSSPPPARSGFYRQ------------EVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGR 48

Query: 61  NNEKVVVKIL-KPVKKK----KIKREIKILENLRGGPNIITLADIVKDPVSRTP----AL 111
              KV +K L +P + +    +  RE+++L+++R   N+I L D+     +        L
Sbjct: 49  TGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRH-ENVIGLLDVFTPDETLDDFTDFYL 107

Query: 112 VFEHVNNTDFKQL--YQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHR 169
           V   +  TD  +L  ++ L +  I+F +Y++LK L Y H+ GI+HRD+KP N+ ++ +  
Sbjct: 108 VMPFM-GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDC- 165

Query: 170 KLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRK 229
           +L+++D+GLA       E    V +R+++ PE+++++  Y  ++D+WS+GC++A MI  K
Sbjct: 166 ELKILDFGLAR--QADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGK 223

Query: 230 EPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSEN 289
              F G D+ DQL  I KV GT    +++ +   +    +   L    +K +   + +  
Sbjct: 224 T-LFKGSDHLDQLKEIMKVTGTPPA-EFVQRLQSDEAKNYMKGLPELEKKDFASILTNA- 280

Query: 290 QHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTV 327
               SP A++ L+K+L  D + R+TA EA+ HPYF ++
Sbjct: 281 ----SPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESL 314


>3LIJ-A nrPDB
          Length = 494

 Score =  296 bits (758), Expect = 1e-80,   Method: Composition-based stats.
 Identities = 81/342 (23%), Positives = 147/342 (42%), Gaps = 57/342 (16%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK-----KKKIKREIKILENLRGG 91
           + YQ V+KLG G Y EV    +   + +  +KI++          K+  E+ +L+ L   
Sbjct: 37  EMYQRVKKLGSGAYGEVLLCRDKVTHVERAIKIIRKTSVSTSSNSKLLEEVAVLK-LLDH 95

Query: 92  PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCH 148
           PNI+ L D  +D   R   LV E     +            + D    + ++L  + Y H
Sbjct: 96  PNIMKLYDFFEDK--RNYYLVMECYKGGELFDEIIHRMKFNEVDAAVIIKQVLSGVTYLH 153

Query: 149 SMGIMHRDVKPHNVMIDHEHRK--LRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDY 206
              I+HRD+KP N++++ + +   ++++D+GL+  +   ++   R+ + Y+  PE+L   
Sbjct: 154 KHNIVHRDLKPENLLLESKEKDALIKIVDFGLSAVFENQKKMKERLGTAYYIAPEVL--R 211

Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 266
           + YD   D+WS+G +L  ++    PF  G  + + L ++ K   T D  ++         
Sbjct: 212 KKYDEKCDVWSIGVILFILLAGYPPF-GGQTDQEILRKVEKGKYTFDSPEW--------- 261

Query: 267 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYT 326
                                     VS  A D + ++L++D Q R++A++A+EHP+   
Sbjct: 262 ------------------------KNVSEGAKDLIKQMLQFDSQRRISAQQALEHPWIK- 296

Query: 327 VVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLGPLA 368
                  M S    G   P S AN +  +        L   A
Sbjct: 297 ------EMCSKKESGIELP-SLANAIENMRKFQNSQKLAQAA 331


>3HZT-A nrPDB
          Length = 467

 Score =  296 bits (758), Expect = 1e-80,   Method: Composition-based stats.
 Identities = 81/346 (23%), Positives = 139/346 (40%), Gaps = 58/346 (16%)

Query: 34  GNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPV------KKKKIKREIKILEN 87
           G  D YQ V+KLG G Y EV    +     +  +KI+K            +  E+ +L+ 
Sbjct: 1   GLSDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQ 60

Query: 88  LRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQ---LYQTLTDYDIRFYMYEILKAL 144
           L   PNI+ L +  +D   R   LV E     +      L Q  ++ D    M ++L   
Sbjct: 61  L-DHPNIMKLYEFFEDK--RNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLSGT 117

Query: 145 DYCHSMGIMHRDVKPHNVMIDHEHRK--LRLIDWGLAEFYHPGQEYNVRVASRYFKGPEL 202
            Y H   I+HRD+KP N++++ + R   ++++D+GL+  +  G +   R+ + Y+  PE+
Sbjct: 118 TYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAPEV 177

Query: 203 LVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYN 262
           L   + YD   D+WS G +L  ++    PF  G  + + L R+ K   + D  D+     
Sbjct: 178 L--RKKYDEKCDVWSCGVILYILLCGYPPF-GGQTDQEILKRVEKGKFSFDPPDWTQ--- 231

Query: 263 IELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHP 322
                                         VS EA   +  +L Y+   R++A EA+ HP
Sbjct: 232 ------------------------------VSDEAKQLVKLMLTYEPSKRISAEEALNHP 261

Query: 323 YFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLGPLA 368
           +         +  S          +    +  +    +   L   A
Sbjct: 262 WI-------VKFCSQKHTDV-GKHALTGALGNMKKFQSSQKLAQAA 299


>4MVF-A nrPDB
          Length = 506

 Score =  296 bits (757), Expect = 1e-80,   Method: Composition-based stats.
 Identities = 76/311 (24%), Positives = 140/311 (45%), Gaps = 47/311 (15%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKR---EIKILENLRGGP 92
           +D Y +  KLG+G Y  V++ I+   N+   +K  K  + K I R   EI+I++ L   P
Sbjct: 56  EDKYIIDEKLGQGTYGCVYKGIDKVTNQLYAIKEEKKDRLKNINRFFQEIEIMKKL-DHP 114

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCHS 149
           NI+ L +  ++       L+ E  +  +         + T+ +    M +I  A+ Y HS
Sbjct: 115 NIVKLYETYEN--DNYIYLIMELCSGRELFDSIIENGSFTEKNAATIMKQIFSAIFYLHS 172

Query: 150 MGIMHRDVKPHNVMIDHEHRK--LRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQ 207
           + I+HRD+KP N +   E++   L++ID+GL++    G+    +  + Y+  P++L    
Sbjct: 173 LNIVHRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFTTTKAGTPYYVAPQVLDG-- 230

Query: 208 MYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDP 267
            YD   D+WS G ++ +++    PF+ G  + + L ++                      
Sbjct: 231 KYDKKCDIWSSGVIMYTLLCGYPPFY-GDTDNEVLKKV---------------------- 267

Query: 268 RFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTV 327
                      K+ E   +  +   +S +A + + KLL Y+   R T  EA+ HP+   +
Sbjct: 268 -----------KKGEFCFYENDWGSISSDAKNLITKLLTYNPNERCTIEEALNHPWITQM 316

Query: 328 VKDQARMGSSS 338
            K    +  SS
Sbjct: 317 TKSHEHVELSS 327


>6GU6-A nrPDB
          Length = 302

 Score =  295 bits (755), Expect = 3e-80,   Method: Composition-based stats.
 Identities = 87/315 (27%), Positives = 165/315 (52%), Gaps = 26/315 (8%)

Query: 32  EWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK-----IKREIKILE 86
             G+ +DY  + K+G G Y  V++  + T  + V +K ++   +++       REI +L+
Sbjct: 2   PLGSMEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLK 61

Query: 87  NLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYD------IRFYMYEI 140
            LR  PNI++L D++         L+FE ++  D K+   ++          ++ Y+Y+I
Sbjct: 62  ELRH-PNIVSLQDVL--MQDSRLYLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQI 117

Query: 141 LKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH-PGQEYNVRVASRYFKG 199
           L+ + +CHS  ++HRD+KP N++ID +   ++L D+GLA  +  P + Y   V + +++ 
Sbjct: 118 LQGIVFCHSRRVLHRDLKPQNLLID-DKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRS 176

Query: 200 PELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYID 259
           PE+L+    Y   +D+WS+G + A +   K+P FHG    DQL RI + LGT +   + +
Sbjct: 177 PEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPE 235

Query: 260 KYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAM 319
             +++          +++  +W+    + +   +    LD L K+L YD   R++ + A+
Sbjct: 236 VESLQ--------DYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMAL 287

Query: 320 EHPYFYTVVKDQARM 334
            HPYF  +     +M
Sbjct: 288 NHPYFNDLDNQIKKM 302


>3MA6-A nrPDB
          Length = 298

 Score =  292 bits (747), Expect = 2e-79,   Method: Composition-based stats.
 Identities = 74/306 (24%), Positives = 139/306 (45%), Gaps = 50/306 (16%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP------VKKKKIKREIKILENLRG 90
           D Y+  R LG+G + EV    +    ++  VK++          K+ + RE+++L+ L  
Sbjct: 32  DRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQL-D 90

Query: 91  GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYC 147
            PNI+ L +  +D       LV E     +        +  ++ D    + ++L  + Y 
Sbjct: 91  HPNIMKLYEFFEDKG--YFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYM 148

Query: 148 HSMGIMHRDVKPHNVMIDHEHR--KLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVD 205
           H   I+HRD+KP N++++ + +   +R+ID+GL+  +   ++   ++ + Y+  PE+L  
Sbjct: 149 HKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVL-- 206

Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIEL 265
           +  YD   D+WS G +L  ++    PF +G + YD L ++ K   T +L  +        
Sbjct: 207 HGTYDEKCDVWSTGVILYILLSGCPPF-NGANEYDILKKVEKGKYTFELPQW-------- 257

Query: 266 DPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFY 325
                                      VS  A D + K+L Y    R++AR+A++H +  
Sbjct: 258 -------------------------KKVSESAKDLIRKMLTYVPSMRISARDALDHEWIQ 292

Query: 326 TVVKDQ 331
           T  K+Q
Sbjct: 293 TYTKEQ 298


>4KRC-A nrPDB
          Length = 317

 Score =  291 bits (745), Expect = 3e-79,   Method: Composition-based stats.
 Identities = 86/318 (27%), Positives = 167/318 (52%), Gaps = 23/318 (7%)

Query: 35  NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK----KIKREIKILENLRG 90
           +   ++ + KLG G Y+ V++ +N T    V +K +K   ++       REI +++ L+ 
Sbjct: 3   SSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKH 62

Query: 91  GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---------QTLTDYDIRFYMYEIL 141
             NI+ L D++         LVFE ++N D K+           + L    ++++ +++L
Sbjct: 63  -ENIVRLYDVIH--TENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLL 118

Query: 142 KALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH-PGQEYNVRVASRYFKGP 200
           + L +CH   I+HRD+KP N++I+    +L+L D+GLA  +  P   ++  V + +++ P
Sbjct: 119 QGLAFCHENKILHRDLKPQNLLINKRG-QLKLGDFGLARAFGIPVNTFSSEVVTLWYRAP 177

Query: 201 ELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDK 260
           ++L+  + Y  S+D+WS GC+LA MI  K P F G ++ +QL  I  ++GT +   +   
Sbjct: 178 DVLMGSRTYSTSIDIWSCGCILAEMITGK-PLFPGTNDEEQLKLIFDIMGTPNESLWP-- 234

Query: 261 YNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAME 320
            ++   P++N  + +   +   + +    +  +    +DFL  LL+ +   RL+A++A+ 
Sbjct: 235 -SVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALH 293

Query: 321 HPYFYTVVKDQARMGSSS 338
           HP+F       +  GS S
Sbjct: 294 HPWFAEYYHHASMGGSRS 311


>3DFA-A nrPDB
          Length = 286

 Score =  291 bits (745), Expect = 4e-79,   Method: Composition-based stats.
 Identities = 71/304 (23%), Positives = 137/304 (45%), Gaps = 49/304 (16%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL-----KPVKKKKIKREIKILENLRGG 91
           + Y +V  LG+G + EV +  +    ++  VK++     K      I RE+++L+ L   
Sbjct: 22  ERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKL-DH 80

Query: 92  PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCH 148
           PNI+ L +I++D  S +  +V E     +        +  +++D    + ++   + Y H
Sbjct: 81  PNIMKLFEILED--SSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMH 138

Query: 149 SMGIMHRDVKPHNVMIDHEHRK--LRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDY 206
              I+HRD+KP N++++ + +   +++ID+GL+  +    +   R+ + Y+  PE+L   
Sbjct: 139 KHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVL--R 196

Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 266
             YD   D+WS G +L  ++    PF+ G + YD L R+              KY  +L 
Sbjct: 197 GTYDEKCDVWSAGVILYILLSGTPPFY-GKNEYDILKRVE-----------TGKYAFDLP 244

Query: 267 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYT 326
                                     +S +A D + K+L +    R+TA + +EHP+   
Sbjct: 245 ----------------------QWRTISDDAKDLIRKMLTFHPSLRITATQCLEHPWIQK 282

Query: 327 VVKD 330
              +
Sbjct: 283 YSSE 286


>4MYG-A nrPDB
          Length = 372

 Score =  290 bits (743), Expect = 6e-79,   Method: Composition-based stats.
 Identities = 93/335 (27%), Positives = 170/335 (50%), Gaps = 22/335 (6%)

Query: 15  VNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK--- 71
           ++  R + ++  + +   W     Y     +G G Y  V  AI+  + EKV +K L    
Sbjct: 21  MSLIRKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPF 80

Query: 72  --PVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRT----PALVFEHVNNTDFKQLY 125
              +  K+  RE+ +L++++   N+I L D+     S        LV   +  TD +++ 
Sbjct: 81  QSEIFAKRAYRELLLLKHMQH-ENVIGLLDVFTPASSLRNFYDFYLVMPFM-QTDLQKIM 138

Query: 126 Q-TLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHP 184
               ++  I++ +Y++LK L Y HS G++HRD+KP N+ ++ +  +L+++D+GLA   H 
Sbjct: 139 GMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDC-ELKILDFGLAR--HA 195

Query: 185 GQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVR 244
             E    V +R+++ PE+++ +  Y+ ++D+WS+GC++A M+  K   F G D  DQL +
Sbjct: 196 DAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKT-LFKGKDYLDQLTQ 254

Query: 245 IAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKL 304
           I KV G     +++ K N +    +   L +  RK + +          SP+A D L+K+
Sbjct: 255 ILKVTGVPGT-EFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRA-----SPQAADLLEKM 308

Query: 305 LRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSM 339
           L  D   RLTA +A+ HP+F      +    +   
Sbjct: 309 LELDVDKRLTAAQALTHPFFEPFRDPEEETEAQQP 343


>1V0B-A nrPDB
          Length = 288

 Score =  290 bits (742), Expect = 7e-79,   Method: Composition-based stats.
 Identities = 89/301 (29%), Positives = 161/301 (53%), Gaps = 25/301 (8%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK-----IKREIKILENLRG 90
            + Y  + K+G G Y  V++A N    E   +K ++  K+ +       REI IL+ L+ 
Sbjct: 1   MEKYHGLEKIGEGTYGVVYKAQN-NYGETFALKKIRLEKEDEGIPSTTIREISILKELKH 59

Query: 91  GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----LTDYDIRFYMYEILKALDY 146
             NI+ L D++     +   LVFEH++  D K+L       L     + ++ ++L  + Y
Sbjct: 60  S-NIVKLYDVIH--TKKRLVLVFEHLDQ-DLKKLLDVCEGGLESVTAKSFLLQLLNGIAY 115

Query: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH-PGQEYNVRVASRYFKGPELLVD 205
           CH   ++HRD+KP N++I+ E  +L++ D+GLA  +  P ++Y   V + +++ P++L+ 
Sbjct: 116 CHDRRVLHRDLKPQNLLINREG-ELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVLMG 174

Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIEL 265
            + Y  ++D+WS+GC+ A M+    P F G    DQL+RI ++LGT +  ++    N+  
Sbjct: 175 SKKYSTTIDIWSVGCIFAEMVNGA-PLFPGVSEADQLMRIFRILGTPNSKNWP---NVTE 230

Query: 266 DPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFY 325
            P+++     +    WE F+       +    +D L K+L+ D   R+TA++A+EH YF 
Sbjct: 231 LPKYDPNFTVYEPLPWESFLKG-----LDESGIDLLSKMLKLDPNQRITAKQALEHAYFK 285

Query: 326 T 326
            
Sbjct: 286 E 286


>3DXN-A nrPDB
          Length = 287

 Score =  290 bits (742), Expect = 7e-79,   Method: Composition-based stats.
 Identities = 78/302 (25%), Positives = 131/302 (43%), Gaps = 50/302 (16%)

Query: 34  GNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPV------KKKKIKREIKILEN 87
           G  D YQ V+KLG G Y EV    +     +  +KI+K            +  E+ +L+ 
Sbjct: 18  GLSDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQ 77

Query: 88  LRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQ---LYQTLTDYDIRFYMYEILKAL 144
           L   PNI+ L +  +D   R   LV E     +      L Q  ++ D    M ++L   
Sbjct: 78  L-DHPNIMKLYEFFEDK--RNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLSGT 134

Query: 145 DYCHSMGIMHRDVKPHNVMIDHEHRK--LRLIDWGLAEFYHPGQEYNVRVASRYFKGPEL 202
            Y H   I+HRD+KP N++++ + R   ++++D+GL+  +  G +   R+ + Y+  PE+
Sbjct: 135 TYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAPEV 194

Query: 203 LVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYN 262
           L   + YD   D+WS G +L  ++    PF  G  + + L R+ K   + D  D+     
Sbjct: 195 L--RKKYDEKCDVWSCGVILYILLCGYPPF-GGQTDQEILKRVEKGKFSFDPPDWTQ--- 248

Query: 263 IELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHP 322
                                         VS EA   +  +L Y+   R++A EA+ HP
Sbjct: 249 ------------------------------VSDEAKQLVKLMLTYEPSKRISAEEALNHP 278

Query: 323 YF 324
           + 
Sbjct: 279 WI 280


>1G3N-A nrPDB
          Length = 326

 Score =  290 bits (742), Expect = 9e-79,   Method: Composition-based stats.
 Identities = 87/324 (26%), Positives = 155/324 (47%), Gaps = 30/324 (9%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNN-EKVVVKILKPVKKKK-----IKREIKILENLR- 89
             Y+ V ++G G Y +VF+A ++ N    V +K ++    ++       RE+ +L +L  
Sbjct: 11  QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70

Query: 90  -GGPNIITLADIV---KDPVSRTPALVFEHVNNTDFKQLYQTLTD-----YDIRFYMYEI 140
              PN++ L D+    +        LVFEHV+  D       + +       I+  M+++
Sbjct: 71  FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQL 129

Query: 141 LKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGP 200
           L+ LD+ HS  ++HRD+KP N+++     +++L D+GLA  Y         V + +++ P
Sbjct: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSG-QIKLADFGLARIYSFQMALTSVVVTLWYRAP 188

Query: 201 ELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDK 260
           E+L+    Y   +D+WS+GC+ A M FR++P F G  + DQL +I  V+G     D+   
Sbjct: 189 EVLLQSS-YATPVDLWSVGCIFAEM-FRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRD 246

Query: 261 YNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAME 320
             +             S +  E+FV       +     D L K L ++   R++A  A+ 
Sbjct: 247 VALP-----RQAFHSKSAQPIEKFVTD-----IDELGKDLLLKCLTFNPAKRISAYSALS 296

Query: 321 HPYFYTVVKDQARMGSSSMPGGST 344
           HPYF  + + +  + S   P  +T
Sbjct: 297 HPYFQDLERCKENLDSHLPPSQNT 320


>4YZB-A nrPDB
          Length = 491

 Score =  289 bits (739), Expect = 2e-78,   Method: Composition-based stats.
 Identities = 75/338 (22%), Positives = 143/338 (42%), Gaps = 51/338 (15%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK-----IKREIKILENLRGG 91
           D Y+  R LG+G + EV    +    ++  VK++   + K+     +  +   L      
Sbjct: 30  DRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTDKELLLKEVELLKKLDH 89

Query: 92  PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCH 148
           PNI+ L +  +D       LV E     +        +  ++ D    + ++L  + Y H
Sbjct: 90  PNIMKLYEFFEDKG--YFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMH 147

Query: 149 SMGIMHRDVKPHNVMIDHEHR--KLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDY 206
              I+HRD+KP N++++++ +   +R+ID+GL+  +   ++   ++ + Y+  PE+L  +
Sbjct: 148 KNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAPEVL--H 205

Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 266
             YD   D+WS G +L  ++    PF +G + +D L ++ K   T DL  +         
Sbjct: 206 GTYDEKCDVWSTGVILYILLSGCPPF-NGANEFDILKKVEKGKFTFDLPQW--------- 255

Query: 267 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYT 326
                                     VS  A D + K+L Y    R++AR+A+EH +  T
Sbjct: 256 ------------------------KKVSEPAKDLIRKMLAYVPTMRISARDALEHEWLKT 291

Query: 327 VVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPL 364
                A   S  +P   + + +     G   +   + L
Sbjct: 292 TD---AATDSIDVPSLESTILNIRQFQGTQKLAAAALL 326


>3OZ6-A nrPDB
          Length = 388

 Score =  286 bits (731), Expect = 2e-77,   Method: Composition-based stats.
 Identities = 93/325 (28%), Positives = 160/325 (49%), Gaps = 42/325 (12%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL-----KPVKKKKIKREIKILENLRGGP 92
            Y+LV+KLG+G Y  V+++I+    E V VK +          ++  REI IL  L G  
Sbjct: 10  KYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIFDAFQNSTDAQRTFREIMILTELSGHE 69

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT--LTDYDIRFYMYEILKALDYCHSM 150
           NI+ L ++++    R   LVF+++  TD   + +   L     ++ +Y+++K + Y HS 
Sbjct: 70  NIVNLLNVLRADNDRDVYLVFDYME-TDLHAVIRANILEPVHKQYVVYQLIKVIKYLHSG 128

Query: 151 GIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFY----------------------HPGQEY 188
           G++HRD+KP N++++ E   +++ D+GL+  +                            
Sbjct: 129 GLLHRDMKPSNILLNAECH-VKVADFGLSRSFVNIRRVTNNIPLSINENTENFDDDQPIL 187

Query: 189 NVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKV 248
              VA+R+++ PE+L+    Y   +DMWSLGC+L  ++  K P F G    +QL RI  V
Sbjct: 188 TDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGK-PIFPGSSTMNQLERIIGV 246

Query: 249 LGTEDLYDYID------KYNIELDPRFNDILGRHSRK---RWERFVHSENQH-LVSPEAL 298
           +      D         K  IE      +I   + R    +W+  +   N     + EAL
Sbjct: 247 IDFPSNEDVESIQSPFAKTMIESLKEKVEIRQSNKRDIFTKWKNLLLKINPKADCNEEAL 306

Query: 299 DFLDKLLRYDHQSRLTAREAMEHPY 323
           D LDKLL+++   R++A +A++HP+
Sbjct: 307 DLLDKLLQFNPNKRISANDALKHPF 331


>4QTB-A nrPDB
          Length = 380

 Score =  285 bits (729), Expect = 2e-77,   Method: Composition-based stats.
 Identities = 90/340 (26%), Positives = 165/340 (48%), Gaps = 29/340 (8%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK----KIKREIKILENLRGGPN 93
            Y  ++ +G G Y  V  A +     +V +K + P + +    +  REI+IL   R   N
Sbjct: 42  RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRH-EN 100

Query: 94  IITLADIVKDPV---SRTPALVFEHVNNTDFKQLYQT--LTDYDIRFYMYEILKALDYCH 148
           +I + DI++       R   +V + +  TD  +L ++  L++  I +++Y+IL+ L Y H
Sbjct: 101 VIGIRDILRASTLEAMRDVYIVQDLME-TDLYKLLKSQQLSNDHICYFLYQILRGLKYIH 159

Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVR----VASRYFKGPELLV 204
           S  ++HRD+KP N++I+     L++ D+GLA    P  ++       VA+R+++ PE+++
Sbjct: 160 SANVLHRDLKPSNLLINTTC-DLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIML 218

Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIE 264
           + + Y  S+D+WS+GC+LA M+  + P F G    DQL  I  +LG+    D     N++
Sbjct: 219 NSKGYTKSIDIWSVGCILAEMLSNR-PIFPGKHYLDQLNHILGILGSPSQEDLNCIINMK 277

Query: 265 LDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324
               +   L   ++  W +     +      +ALD LD++L ++   R+T  EA+ HPY 
Sbjct: 278 AR-NYLQSLPSKTKVAWAKLFPKSD-----SKALDLLDRMLTFNPNKRITVEEALAHPYL 331

Query: 325 YTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPL 364
                       +  P    P + A  +  +        +
Sbjct: 332 EQY------YDPTDEPVAEEPFTFAMELDDLPKERLKELI 365


>5NGU-A nrPDB
          Length = 381

 Score =  284 bits (728), Expect = 3e-77,   Method: Composition-based stats.
 Identities = 93/340 (27%), Positives = 164/340 (48%), Gaps = 29/340 (8%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK----KIKREIKILENLRGGPN 93
            Y  +  +G G Y  V  A +  N  +V +K + P + +    +  REIKIL   R   N
Sbjct: 43  RYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRH-EN 101

Query: 94  IITLADIVKDPV---SRTPALVFEHVNNTDFKQLYQT--LTDYDIRFYMYEILKALDYCH 148
           II + DI++ P     +   +V + +  TD  +L +T  L++  I +++Y+IL+ L Y H
Sbjct: 102 IIGINDIIRAPTIEQMKDVYIVQDLME-TDLYKLLKTQHLSNDHICYFLYQILRGLKYIH 160

Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVR----VASRYFKGPELLV 204
           S  ++HRD+KP N++++     L++ D+GLA    P  ++       VA+R+++ PE+++
Sbjct: 161 SANVLHRDLKPSNLLLNTTC-DLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIML 219

Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIE 264
           + + Y  S+D+WS+GC+LA M+  + P F G    DQL  I  +LG+    D     N++
Sbjct: 220 NSKGYTKSIDIWSVGCILAEMLSNR-PIFPGKHYLDQLNHILGILGSPSQEDLNCIINLK 278

Query: 265 LDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324
               +   L   ++  W R   + +      +ALD LDK+L ++   R+   +A+ HPY 
Sbjct: 279 AR-NYLLSLPHKNKVPWNRLFPNAD-----SKALDLLDKMLTFNPHKRIEVEQALAHPYL 332

Query: 325 YTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPL 364
                       S  P    P      +  +        +
Sbjct: 333 EQY------YDPSDEPIAEAPFKFDMELDDLPKEKLKELI 366


>2F9G-A nrPDB
          Length = 353

 Score =  284 bits (727), Expect = 5e-77,   Method: Composition-based stats.
 Identities = 90/324 (27%), Positives = 156/324 (48%), Gaps = 28/324 (8%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK----KIKREIKILENLRGGPN 93
           D+QL   LG G Y  V  A +    E V +K ++P  K     +  REIKIL++ +   N
Sbjct: 12  DFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKH-EN 70

Query: 94  IITLADIVKDPVSRTP--ALVFEHVNNTDFKQLY--QTLTDYDIRFYMYEILKALDYCHS 149
           IIT+ +I +           + + +  TD  ++   Q L+D  I++++Y+ L+A+   H 
Sbjct: 71  IITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHG 130

Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE-----------YNVRVASRYFK 198
             ++HRD+KP N++I+  +  L++ D+GLA                       VA+R+++
Sbjct: 131 SNVIHRDLKPSNLLINS-NCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYR 189

Query: 199 GPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYI 258
            PE+++    Y  ++D+WS GC+LA +  R+ P F G D   QL+ I  ++GT    + +
Sbjct: 190 APEVMLTSAKYSRAMDVWSCGCILAELFLRR-PIFPGRDYRHQLLLIFGIIGTPHSDNDL 248

Query: 259 DKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREA 318
                     +   L  +     E+         V+P+ +D L ++L +D   R+TA+EA
Sbjct: 249 RCIESPRAREYIKSLPMYPAAPLEKMFP-----RVNPKGIDLLQRMLVFDPAKRITAKEA 303

Query: 319 MEHPYFYTV-VKDQARMGSSSMPG 341
           +EHPY  T    +    G    P 
Sbjct: 304 LEHPYLQTYHDPNDEPEGEPIPPS 327


>4AGU-A nrPDB
          Length = 311

 Score =  284 bits (726), Expect = 6e-77,   Method: Composition-based stats.
 Identities = 88/324 (27%), Positives = 154/324 (47%), Gaps = 34/324 (10%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL-----KPVKKKKIKREIKILENLRG 90
            + Y+ + K+G G Y  VF+  N    + V +K        PV KK   REI++L+ L+ 
Sbjct: 2   MEKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKH 61

Query: 91  GPNIITLADIVKDPVSRTPALVFEHVNNT---DFKQLYQTLTDYDIRFYMYEILKALDYC 147
            PN++ L ++ +    R   LVFE+ ++T   +  +  + + ++ ++   ++ L+A+++C
Sbjct: 62  -PNLVNLLEVFRRK--RRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFC 118

Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH-PGQEYNVRVASRYFKGPELLVDY 206
           H    +HRDVKP N++I  +H  ++L D+G A     P   Y+  VA+R+++ PELLV  
Sbjct: 119 HKHNCIHRDVKPENILIT-KHSVIKLCDFGFARLLTGPSDYYDDEVATRWYRSPELLVGD 177

Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 266
             Y   +D+W++GC+ A ++    P + G  + DQL  I K LG             +L 
Sbjct: 178 TQYGPPVDVWAIGCVFAELLSG-VPLWPGKSDVDQLYLIRKTLG-------------DLI 223

Query: 267 PRFNDILGRHSRKRWERFVHSENQHL-------VSPEALDFLDKLLRYDHQSRLTAREAM 319
           PR   +   +      +    E+          +S  AL  L   L  D   RLT  + +
Sbjct: 224 PRHQQVFSTNQYFSGVKIPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTERLTCEQLL 283

Query: 320 EHPYFYTVVKDQARMGSSSMPGGS 343
            HPYF  + + +        P  +
Sbjct: 284 HHPYFENIREIEDLAKEHDKPAEN 307


>5EFQ-A nrPDB
          Length = 347

 Score =  284 bits (726), Expect = 6e-77,   Method: Composition-based stats.
 Identities = 88/331 (26%), Positives = 164/331 (49%), Gaps = 34/331 (10%)

Query: 31  VEWGNQ--DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK-----IKREIK 83
           ++WG +  D + ++  +G G Y +V++A +    E V +K ++   +K+       REIK
Sbjct: 3   IDWGKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIK 62

Query: 84  ILENLRGGPNIITLADIVKDPVS--------RTPALVFEHVNNTDFKQLYQT----LTDY 131
           IL  L    +II + +IV D               LVFE++++ D   L ++      + 
Sbjct: 63  ILRQLTHQ-SIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDH-DLMGLLESGLVHFNEN 120

Query: 132 DIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFY--HPGQEYN 189
            I+ +M ++++ LDYCH    +HRD+K  N+++++   +++L D+GLA  Y     + Y 
Sbjct: 121 HIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRG-QIKLADFGLARLYSSEESRPYT 179

Query: 190 VRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVL 249
            +V + +++ PELL+  + Y  ++D+WS GC+L  +   K+P F  +    QL  I+++ 
Sbjct: 180 NKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFT-KKPIFQANQELAQLELISRIC 238

Query: 250 GTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDH 309
           G+     + D   +   P FN +  +   +R  R    E    +   ALD  D +L  D 
Sbjct: 239 GSPCPAVWPDVIKL---PYFNTMKPKKQYRRKLR----EEFVFIPAAALDLFDYMLALDP 291

Query: 310 QSRLTAREAMEHPYFYTVVKDQARMGSSSMP 340
             R TA +A++  +   V    ++M    +P
Sbjct: 292 SKRCTAEQALQCEFLRDVEP--SKMPPPDLP 320


>3Q5I-A nrPDB
          Length = 504

 Score =  283 bits (724), Expect = 1e-76,   Method: Composition-based stats.
 Identities = 74/354 (20%), Positives = 143/354 (40%), Gaps = 69/354 (19%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK----------------KKKIKR 80
           + Y  VRKLG G Y EV        + +  +K++K  +                 ++I  
Sbjct: 36  ESYFKVRKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYSDDNKNIEKFHEEIYN 95

Query: 81  EIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYM 137
           EI +L++L   PNII L D+ +D   +   LV E     +  +         + D    M
Sbjct: 96  EISLLKSL-DHPNIIKLFDVFEDK--KYFYLVTEFYEGGELFEQIINRHKFDECDAANIM 152

Query: 138 YEILKALDYCHSMGIMHRDVKPHNVMIDHEHR--KLRLIDWGLAEFYHPGQEYNVRVASR 195
            +IL  + Y H   I+HRD+KP N+++++++    ++++D+GL+ F+    +   R+ + 
Sbjct: 153 KQILSGICYLHKHNIVHRDIKPENILLENKNSLLNIKIVDFGLSSFFSKDYKLRDRLGTA 212

Query: 196 YFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLY 255
           Y+  PE+L   + Y+   D+WS G ++  ++    PF  G ++ D + ++ K        
Sbjct: 213 YYIAPEVL--KKKYNEKCDVWSCGVIMYILLCGYPPF-GGQNDQDIIKKVEK-------- 261

Query: 256 DYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTA 315
                                     + +    +   +S EA + +  +L YD+  R TA
Sbjct: 262 -------------------------GKYYFDFNDWKNISDEAKELIKLMLTYDYNKRCTA 296

Query: 316 REAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLGPLAG 369
            EA+   +      +  +    ++ G          +S +        L   A 
Sbjct: 297 EEALNSRWIKKYANNINKSDQKTLCG---------ALSNMRKFEGSQKLAQAAI 341


>6DTL-A nrPDB
          Length = 364

 Score =  282 bits (721), Expect = 2e-76,   Method: Composition-based stats.
 Identities = 80/297 (26%), Positives = 153/297 (51%), Gaps = 22/297 (7%)

Query: 42  VRKLGRGKYSEVFEAINITNNEKVVVKIL-----KPVKKKKIKREIKILENLRGGPNIIT 96
           +  +G+G Y  V  A+N   NE V +K +       +  K+  REIK+L +     NI+ 
Sbjct: 35  IMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRH-MDHENIVA 93

Query: 97  LADIVKDPVSR---TPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYCHSM 150
           + DI+  P+        + +E ++ TD  Q+ ++   L++   ++++Y+IL+ L Y HS 
Sbjct: 94  IRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSA 152

Query: 151 GIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYD 210
            ++HRD+KP N++++  +  L++ D+GLA            V +R+++ PELL++   Y 
Sbjct: 153 NVLHRDLKPSNLLLNA-NCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYT 211

Query: 211 YSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFN 270
            ++D+WS+GC+   ++ RK P F G D+  QL  + +++GT    +              
Sbjct: 212 AAIDVWSVGCIFMELMDRK-PLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKR---- 266

Query: 271 DILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTV 327
                     + R   ++    V P A+D ++K+L +D + R+T  +A+ HPY  ++
Sbjct: 267 ---YIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSL 320


>3GC9-A nrPDB
          Length = 370

 Score =  281 bits (719), Expect = 4e-76,   Method: Composition-based stats.
 Identities = 96/355 (27%), Positives = 170/355 (47%), Gaps = 25/355 (7%)

Query: 22  EYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP-----VKKK 76
            ++  E +   W      Q +R +G G Y  V  A +    +KV VK L       +  +
Sbjct: 13  GFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHAR 72

Query: 77  KIKREIKILENLRGGPNIITLADIVKDPVS----RTPALVFEHVNNTDFKQLYQT--LTD 130
           +  RE+++L++L+   N+I L D+     S        LV   +   D   + ++  L+D
Sbjct: 73  RTYRELRLLKHLKH-ENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKSQALSD 130

Query: 131 YDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNV 190
             ++F +Y++L+ L Y HS GI+HRD+KP NV ++ E  +LR++D+GLA      +E   
Sbjct: 131 EHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVN-EDSELRILDFGLAR--QADEEMTG 187

Query: 191 RVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLG 250
            VA+R+++ PE+++++  Y+ ++D+WS+GC++A ++  K   F G D  DQL RI +V+G
Sbjct: 188 YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKA-LFPGSDYIDQLKRIMEVVG 246

Query: 251 TEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQ 310
           T    + + K + E    +   L    +K         N     P A+D L ++L  D  
Sbjct: 247 TPS-PEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGAN-----PLAIDLLGRMLVLDSD 300

Query: 311 SRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLG 365
            R++A EA+ H YF             + P   +  +    +     +     L 
Sbjct: 301 QRVSAAEALAHAYFSQY--HDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLS 353


>4AU8-A nrPDB
          Length = 296

 Score =  281 bits (718), Expect = 5e-76,   Method: Composition-based stats.
 Identities = 86/300 (28%), Positives = 152/300 (50%), Gaps = 23/300 (7%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK-----IKREIKILENLRGG 91
             Y+ + K+G G Y  VF+A N   +E V +K ++     +       REI +L+ L+  
Sbjct: 6   QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH- 64

Query: 92  PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----LTDYDIRFYMYEILKALDYC 147
            NI+ L D++     +   LVFE  +  D K+ + +    L    ++ +++++LK L +C
Sbjct: 65  KNIVRLHDVLHS--DKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFC 121

Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH-PGQEYNVRVASRYFKGPELLVDY 206
           HS  ++HRD+KP N++I+  + +L+L D+GLA  +  P + Y+  V + +++ P++L   
Sbjct: 122 HSRNVLHRDLKPQNLLINR-NGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGA 180

Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 266
           ++Y  S+DMWS GC+ A +     P F G+D  DQL RI ++LGT     +     +   
Sbjct: 181 KLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDY 240

Query: 267 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYT 326
             +       S               ++    D L  LL+ +   R++A EA++HPYF  
Sbjct: 241 KPYPMYPATTS--------LVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 292


>4NST-A nrPDB
          Length = 351

 Score =  280 bits (716), Expect = 8e-76,   Method: Composition-based stats.
 Identities = 85/330 (25%), Positives = 166/330 (50%), Gaps = 34/330 (10%)

Query: 32  EWGNQ--DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK-----IKREIKI 84
           +WG +  D + ++  +G G Y +V++A +    E V +K ++   +K+       REIKI
Sbjct: 6   DWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKI 65

Query: 85  LENLRGGPNIITLADIVKDPVS--------RTPALVFEHVNNTDFKQLYQT----LTDYD 132
           L  L    +++ + +IV D               LVFE++++ D   L ++     ++  
Sbjct: 66  LRQLIH-RSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDH-DLMGLLESGLVHFSEDH 123

Query: 133 IRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE--YNV 190
           I+ +M ++++ L+YCH    +HRD+K  N+++++   +++L D+GLA  Y+  +   Y  
Sbjct: 124 IKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSG-QIKLADFGLARLYNSEESRPYTN 182

Query: 191 RVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLG 250
           +V + +++ PELL+  + Y  ++D+WS GC+L  +   K+P F  +    QL  I+++ G
Sbjct: 183 KVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFT-KKPIFQANLELAQLELISRLCG 241

Query: 251 TEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQ 310
           +     + D   +   P FN +  +   +R  R    E    +   ALD LD +L  D  
Sbjct: 242 SPCPAVWPDVIKL---PYFNTMKPKKQYRRRLR----EEFSFIPSAALDLLDHMLTLDPS 294

Query: 311 SRLTAREAMEHPYFYTVVKDQARMGSSSMP 340
            R TA + ++  +   V  + ++M    +P
Sbjct: 295 KRCTAEQTLQSDFLKDV--ELSKMAPPDLP 322


>4RGJ-A nrPDB
          Length = 520

 Score =  279 bits (715), Expect = 1e-75,   Method: Composition-based stats.
 Identities = 71/345 (20%), Positives = 148/345 (42%), Gaps = 59/345 (17%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL------KPVKKKKIKREIKILENLR 89
            + Y+ ++ LG+G + EV  + +     +  +K++      +   K+ + RE+++L+ L 
Sbjct: 59  NEQYKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKESLLREVELLKMLD 118

Query: 90  GGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDY 146
              NI+ L +  +D  +    LV +     +        +   + D    + +IL  + Y
Sbjct: 119 HI-NIMKLYEFFED--NNYYYLVSDVYTGGELFDEIISRKRFYEIDAARIIKQILSGITY 175

Query: 147 CHSMGIMHRDVKPHNVMIDHEHRK---LRLIDWGLAEFYHPGQEYNVRVASRYFKGPELL 203
            H   ++HRD+KP N++++ ++++   +++ID+GL+  +   ++   ++ + Y+  P++L
Sbjct: 176 MHKNNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHFEYSKKMKDKIGTAYYIAPDVL 235

Query: 204 VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNI 263
             +  YD   D+WS G +L  ++    PF +G + YD L ++     T DL  +      
Sbjct: 236 --HGTYDEKCDIWSCGVILYILLSGCPPF-NGSNEYDILKKVEAGKYTFDLPQF------ 286

Query: 264 ELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323
                                        +S +A D + K+L Y    R++AR+A+EH +
Sbjct: 287 ---------------------------KKISDKAKDLIKKMLMYTSAVRISARDALEHEW 319

Query: 324 FYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLGPLA 368
                     M S        P S    ++ I    +   L   A
Sbjct: 320 IK-------MMTSKDNLNIDIP-SLELSIANIRQFQSTQKLAQAA 356


>4E7W-A nrPDB
          Length = 394

 Score =  279 bits (715), Expect = 1e-75,   Method: Composition-based stats.
 Identities = 104/333 (31%), Positives = 168/333 (50%), Gaps = 29/333 (8%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIK-REIKILENLRGGPNIITL 97
           Y   + +G G +  VF+A  + ++E V +K  K ++ K+ K RE++I+  ++  PN++ L
Sbjct: 42  YTNCKVIGNGSFGVVFQAKLVESDE-VAIK--KVLQDKRFKNRELQIMRIVKH-PNVVDL 97

Query: 98  ADIVKDPVSRT----PALVFEHVNNTDFK------QLYQTLTDYDIRFYMYEILKALDYC 147
                    +       LV E+V  T ++      +L QT+    I+ YMY++L++L Y 
Sbjct: 98  KAFFYSNGDKKDEVFLNLVLEYVPETVYRASRHYAKLKQTMPMLLIKLYMYQLLRSLAYI 157

Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQ 207
           HS+GI HRD+KP N+++D     L+LID+G A+    G+     + SRY++ PEL+    
Sbjct: 158 HSIGICHRDIKPQNLLLDPPSGVLKLIDFGSAKILIAGEPNVSYICSRYYRAPELIFGAT 217

Query: 208 MYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDP 267
            Y  ++D+WS GC++A ++  + P F G    DQLV I KVLGT             ++ 
Sbjct: 218 NYTTNIDIWSTGCVMAELMQGQ-PLFPGESGIDQLVEIIKVLGTPSREQIKTMNPNYMEH 276

Query: 268 RFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTV 327
           +F  I      K +        +    P+A+D + +LL Y   +RLTA EA+ HP+F   
Sbjct: 277 KFPQIRPHPFSKVF--------RPRTPPDAIDLISRLLEYTPSARLTAIEALCHPFF--- 325

Query: 328 VKDQARMGSSSMPGGSTPVSSANMMSGISSVPT 360
             D+ R G + MP G       N      SV  
Sbjct: 326 --DELRTGEARMPNGRELPPLFNWTKEELSVRP 356


>5FG8-A nrPDB
          Length = 285

 Score =  276 bits (707), Expect = 9e-75,   Method: Composition-based stats.
 Identities = 70/299 (23%), Positives = 135/299 (45%), Gaps = 49/299 (16%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK-----KKIKREIKILENLRGG 91
           D+Y +  +LG+G +S V   +  +   +   KI+   K      +K++RE +I   L   
Sbjct: 14  DNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKL-HH 72

Query: 92  PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCH 148
           PNI+ L D +++       LVF+ V   +  +     +  ++ D    + +IL+++++CH
Sbjct: 73  PNIVRLHDSIQE--ENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCH 130

Query: 149 SMGIMHRDVKPHNVMIDH--EHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLVD 205
             G++HRD+KP N+++    +   ++L D+GLA E     Q +     +  +  PE+L  
Sbjct: 131 QNGVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVL-K 189

Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIEL 265
            + Y  S+D+W+ G +L  ++    PF+    +               LY  I     + 
Sbjct: 190 KEPYGKSVDIWACGVILYILLVGYPPFWDEDQH--------------RLYSQIKAGAYDY 235

Query: 266 DPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324
                                S     V+PEA + ++++L  +   R+TA EA++HP+ 
Sbjct: 236 P--------------------SPEWDTVTPEAKNLINQMLTVNPNKRITAAEALKHPWI 274


>3HDN-A nrPDB
          Length = 373

 Score =  276 bits (706), Expect = 1e-74,   Method: Composition-based stats.
 Identities = 80/360 (22%), Positives = 142/360 (39%), Gaps = 59/360 (16%)

Query: 34  GNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVK------ILKPVKKKKIKREIKILEN 87
               D+  ++ +G+G + +V  A +        VK      ILK  ++K I  E  +L  
Sbjct: 35  AKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLK 94

Query: 88  LRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKAL 144
               P ++ L    +   +     V +++N  +     Q      +   RFY  EI  AL
Sbjct: 95  NVKHPFLVGLHFSFQ--TADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASAL 152

Query: 145 DYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF-YHPGQEYNVRVASRYFKGPELL 203
            Y HS+ I++RD+KP N+++D +   + L D+GL +         +    +  +  PE+L
Sbjct: 153 GYLHSLNIVYRDLKPENILLDSQGHIV-LTDFGLCKENIEHNSTTSTFCGTPEYLAPEVL 211

Query: 204 VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNI 263
              Q YD ++D W LG +L  M++   PF+  +              T ++YD I    +
Sbjct: 212 -HKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRN--------------TAEMYDNILNKPL 256

Query: 264 ELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAR----EAM 319
           +L P                         ++  A   L+ LL+ D   RL A+    E  
Sbjct: 257 QLKPN------------------------ITNSARHLLEGLLQKDRTKRLGAKDDFMEIK 292

Query: 320 EHPYFYTVVKD---QARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLGPLAGSPVIAAA 376
            H +F  +  D     ++     P  S P    +     +  P P+ +G    S ++ A+
Sbjct: 293 SHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNAIGKAPDSVLVTAS 352


>4IC8-A nrPDB
          Length = 442

 Score =  276 bits (705), Expect = 1e-74,   Method: Composition-based stats.
 Identities = 91/380 (23%), Positives = 170/380 (44%), Gaps = 33/380 (8%)

Query: 2   SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITN 61
            GPV +           +        S  V +   D+Y+++  +G G Y  V  A     
Sbjct: 20  PGPVKAEPAHTAASVAAKNLALLKARSFDVTFDVGDEYEIIETIGNGAYGVVSSARRRLT 79

Query: 62  NEKVVVKILKP-----VKKKKIKREIKILENLRGGPNIITLADIVKDPV----SRTPALV 112
            ++V +K +          K+  RE+KIL++ +   NII + DI++  V     ++  +V
Sbjct: 80  GQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHD-NIIAIKDILRPTVPYGEFKSVYVV 138

Query: 113 FEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHR 169
            + +  +D  Q+    Q LT   +R+++Y++L+ L Y HS  ++HRD+KP N++++ E+ 
Sbjct: 139 LDLME-SDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVN-ENC 196

Query: 170 KLRLIDWGLAEFYHPGQE-----YNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLAS 224
           +L++ D+G+A                 VA+R+++ PEL++    Y  ++D+WS+GC+   
Sbjct: 197 ELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGE 256

Query: 225 MIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERF 284
           M+ R++  F G +   QL  I  VLGT      I     E    +   L       WE  
Sbjct: 257 MLARRQ-LFPGKNYVHQLQLIMMVLGTPS-PAVIQAVGAERVRAYIQSLPPRQPVPWETV 314

Query: 285 VHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGST 344
               ++     +AL  L ++LR++  +R++A  A+ HP+                P  + 
Sbjct: 315 YPGADR-----QALSLLGRMLRFEPSARISAAAALRHPFLAKYH------DPDDEPDCAP 363

Query: 345 PVSSANMMSGISSVPTPSPL 364
           P   A     ++       +
Sbjct: 364 PFDFAFDREALTRERIKEAI 383


>5AWM-A nrPDB
          Length = 394

 Score =  275 bits (703), Expect = 2e-74,   Method: Composition-based stats.
 Identities = 80/346 (23%), Positives = 155/346 (44%), Gaps = 28/346 (8%)

Query: 17  THRPREYWDYESHVVEWGNQD-----DYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL- 70
           +HR      ++ + VE G+ +      Y  +R +G G    V  A +    + V +K L 
Sbjct: 19  SHRTMTTAQHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLS 78

Query: 71  ----KPVKKKKIKREIKILENLRGGPNIITLADIVKD----PVSRTPALVFEHVNNTDFK 122
                    K+  RE K+++ L    NII L +           +   LV E ++    +
Sbjct: 79  RPFQNVTHAKRAYREFKLMK-LVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQ 137

Query: 123 QLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFY 182
            +   L    + + +Y++L  + + HS GI+HRD+KP N+++  +   L+++D+GLA   
Sbjct: 138 VIQMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADC-TLKILDFGLARTA 196

Query: 183 HPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQL 242
                    V +RY++ PE+++    Y  ++D+WS+GC++  MI      F G D+ DQ 
Sbjct: 197 GTTFMMTPYVVTRYYRAPEVILGM-GYTENVDIWSVGCIMGEMIRGGV-LFPGTDHIDQW 254

Query: 243 VRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHS--------ENQHLVS 294
            +I + LGT     ++ +    +   + +   R++   ++R            +N    +
Sbjct: 255 NKIIEQLGTPS-PSFMQRLQPTVR-NYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKA 312

Query: 295 PEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMP 340
            +A + L K+L  D + R++  EA++H Y       +     +  P
Sbjct: 313 SDARNLLSKMLVIDPEQRISVDEALKHEYINVWYDAEEVDAPAPEP 358


>2VN9-A nrPDB
          Length = 301

 Score =  275 bits (703), Expect = 3e-74,   Method: Composition-based stats.
 Identities = 76/299 (25%), Positives = 135/299 (45%), Gaps = 49/299 (16%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK-----KKKIKREIKILENLRGG 91
           D+YQL  +LG+G +S V   + I   ++   KI+   K      +K++RE +I   L+  
Sbjct: 4   DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKH- 62

Query: 92  PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCH 148
           PNI+ L D + +       LVF+ V   +  +     +  ++ D    + +IL+++++CH
Sbjct: 63  PNIVRLHDSISEEGFH--YLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCH 120

Query: 149 SMGIMHRDVKPHNVMI--DHEHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLVD 205
             GI+HRD+KP N+++    +   ++L D+GLA E     Q +     +  +  PE+L  
Sbjct: 121 LNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRK 180

Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIEL 265
              Y   +DMW+ G +L  ++    PF+    +               LY  I     + 
Sbjct: 181 -DPYGKPVDMWACGVILYILLVGYPPFWDEDQH--------------RLYQQIKAGAYDF 225

Query: 266 DPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324
                                S     V+PEA D ++K+L  +   R+TA EA++HP+ 
Sbjct: 226 P--------------------SPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWI 264


>4QNY-A nrPDB
          Length = 354

 Score =  274 bits (702), Expect = 3e-74,   Method: Composition-based stats.
 Identities = 92/308 (29%), Positives = 162/308 (52%), Gaps = 24/308 (7%)

Query: 37  DDYQLVRKLGRGKYSEVFEAIN-ITNNEKVVVKILKP------VKKKKIKREIKILENLR 89
           D Y L R +G G Y  V  A +  ++N  V +K +        +  K+I REIK+L +  
Sbjct: 20  DRYLLERIIGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFEEVILAKRILREIKLLAHF- 78

Query: 90  GGPNIITLADIV--KDPVS-RTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKA 143
              NII L +I+  +DP +     +V + +  TD KQ+ ++   LT+  I+F++Y+ L+A
Sbjct: 79  NDDNIIGLRNILTPEDPENFDHFYIVMDIME-TDLKQVLRSGQELTEAHIQFFIYQALRA 137

Query: 144 LDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHP-GQEYNVRVASRYFKGPEL 202
           L   HS G++HRD+ P N++++  +  L++ D+GLA+  +  G+     V  R+++ PEL
Sbjct: 138 LHIIHSAGVIHRDITPANILVNT-NCDLKICDFGLAKEENDQGEYMTDYVTMRWYRAPEL 196

Query: 203 LVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYN 262
           +++ + Y   +D+W +GC+L  ++    P F G D  +QL +I  V+GT    D I+   
Sbjct: 197 VMEDKDYSAQIDVWGIGCILGELL-GSRPLFQGKDRVNQLDKIVDVIGTPSEED-INSVG 254

Query: 263 IELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHP 322
                ++        +  W +   +      SPEALD L  +L ++ + R+T  +AM HP
Sbjct: 255 SSAAQKYLKKKSHRPQADWRQRYPTA-----SPEALDLLRHMLVFNPKRRITVLQAMRHP 309

Query: 323 YFYTVVKD 330
           +   +  D
Sbjct: 310 FLEQLHDD 317


>2BDW-A nrPDB
          Length = 362

 Score =  274 bits (702), Expect = 3e-74,   Method: Composition-based stats.
 Identities = 70/298 (23%), Positives = 136/298 (45%), Gaps = 48/298 (16%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK-----KKIKREIKILENLRGG 91
           D+Y +  +LG+G +S V   ++ T   +   KI+   K      +K++RE +I   L+  
Sbjct: 29  DNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQH- 87

Query: 92  PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCH 148
           PNI+ L D +++       LVF+ V   +  +     +  ++ D    + +IL+++ YCH
Sbjct: 88  PNIVRLHDSIQEESFH--YLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCH 145

Query: 149 SMGIMHRDVKPHNVMIDH--EHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDY 206
           S GI+HR++KP N+++    +   ++L D+GLA   +  + ++    +  +  PE+L   
Sbjct: 146 SNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVL-KK 204

Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 266
             Y   +D+W+ G +L  ++    PF+    + DQ    A++      Y           
Sbjct: 205 DPYSKPVDIWACGVILYILLVGYPPFW----DEDQHRLYAQIKAGAYDY----------- 249

Query: 267 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324
                               S     V+PEA   +D +L  + + R+TA +A++ P+ 
Sbjct: 250 -------------------PSPEWDTVTPEAKSLIDSMLTVNPKKRITADQALKVPWI 288


>3KK8-A nrPDB
          Length = 284

 Score =  273 bits (697), Expect = 1e-73,   Method: Composition-based stats.
 Identities = 70/298 (23%), Positives = 136/298 (45%), Gaps = 48/298 (16%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK-----KKIKREIKILENLRGG 91
           D+Y +  +LG+G +S V   ++ T   +   KI+   K      +K++RE +I   L+  
Sbjct: 6   DNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQH- 64

Query: 92  PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCH 148
           PNI+ L D +++       LVF+ V   +  +     +  ++ D    + +IL+++ YCH
Sbjct: 65  PNIVRLHDSIQEESFH--YLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCH 122

Query: 149 SMGIMHRDVKPHNVMIDH--EHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDY 206
           S GI+HR++KP N+++    +   ++L D+GLA   +  + ++    +  +  PE+L   
Sbjct: 123 SNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVL-KK 181

Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 266
             Y   +D+W+ G +L  ++    PF+    + DQ    A++      Y           
Sbjct: 182 DPYSKPVDIWACGVILYILLVGYPPFW----DEDQHRLYAQIKAGAYDY----------- 226

Query: 267 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324
                               S     V+PEA   +D +L  + + R+TA +A++ P+ 
Sbjct: 227 -------------------PSPEWDTVTPEAKSLIDSMLTVNPKKRITADQALKVPWI 265


>4ZSG-A nrPDB
          Length = 347

 Score =  271 bits (694), Expect = 2e-73,   Method: Composition-based stats.
 Identities = 87/351 (24%), Positives = 164/351 (46%), Gaps = 33/351 (9%)

Query: 31  VEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP-----VKKKKIKREIKIL 85
           V +   D+Y+++  +G G Y  V  A      ++V +K +          K+  RE+KIL
Sbjct: 1   VTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKIL 60

Query: 86  ENLRGGPNIITLADIVKDPV----SRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMY 138
           ++ +   NII + DI++  V     ++  +V + +  +D  Q+    Q LT   +R+++Y
Sbjct: 61  KHFKHD-NIIAIKDILRPTVPYGEFKSVYVVLDLME-SDLHQIIHSSQPLTLEHVRYFLY 118

Query: 139 EILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE-----YNVRVA 193
           ++L+ L Y HS  ++HRD+KP N++++ E+ +L++ D+G+A                 VA
Sbjct: 119 QLLRGLKYMHSAQVIHRDLKPSNLLVN-ENCELKIGDFGMARGLCTSPAEHQYFMTEYVA 177

Query: 194 SRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTED 253
           +R+++ PEL++    Y  ++D+WS+GC+   M+ R++  F G +   QL  I  VLGT  
Sbjct: 178 TRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQ-LFPGKNYVHQLQLIMMVLGTPS 236

Query: 254 LYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRL 313
               I     E    +   L       WE      ++     +AL  L ++LR++  +R+
Sbjct: 237 -PAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADR-----QALSLLGRMLRFEPSARI 290

Query: 314 TAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPL 364
           +A  A+ HP+                P  + P   A     ++       +
Sbjct: 291 SAAAALRHPFLAKYH------DPDDEPDCAPPFDFAFDREALTRERIKEAI 335


>4BBM-A nrPDB
          Length = 331

 Score =  271 bits (694), Expect = 3e-73,   Method: Composition-based stats.
 Identities = 86/312 (27%), Positives = 147/312 (47%), Gaps = 24/312 (7%)

Query: 25  DYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL-----KPVKKKKIK 79
           D  +  + + + + Y+ +  +G G Y  V +  N      V +K         + KK   
Sbjct: 13  DLGTENLYFQSMEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAM 72

Query: 80  REIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNT---DFKQLYQTLTDYDIRFY 136
           REIK+L+ LR   N++ L ++ K    +   LVFE V++T   D +     L    ++ Y
Sbjct: 73  REIKLLKQLRH-ENLVNLLEVCKKK--KRWYLVFEFVDHTILDDLELFPNGLDYQVVQKY 129

Query: 137 MYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFY-HPGQEYNVRVASR 195
           +++I+  + +CHS  I+HRD+KP N+++  +   ++L D+G A     PG+ Y+  VA+R
Sbjct: 130 LFQIINGIGFCHSHNIIHRDIKPENILV-SQSGVVKLCDFGFARTLAAPGEVYDDEVATR 188

Query: 196 YFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGT--ED 253
           +++ PELLV    Y  ++D+W++GC++  M    EP F G  + DQL  I   LG     
Sbjct: 189 WYRAPELLVGDVKYGKAVDVWAIGCLVTEMFMG-EPLFPGDSDIDQLYHIMMCLGNLIPR 247

Query: 254 LYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRL 313
             +  +K  +    R  +I  R   +R            +S   +D   K L  D   R 
Sbjct: 248 HQELFNKNPVFAGVRLPEIKEREPLER--------RYPKLSEVVIDLAKKCLHIDPDKRP 299

Query: 314 TAREAMEHPYFY 325
              E + H +F 
Sbjct: 300 FCAELLHHDFFQ 311


>3E7O-A nrPDB
          Length = 360

 Score =  271 bits (693), Expect = 3e-73,   Method: Composition-based stats.
 Identities = 76/301 (25%), Positives = 138/301 (45%), Gaps = 18/301 (5%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP-----VKKKKIKREIKILENLRGGP 92
            YQ ++ +G G    V  A +      V VK L          K+  RE+ +L+      
Sbjct: 23  RYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLK-CVNHK 81

Query: 93  NIITLADIVKD----PVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCH 148
           NII+L ++          +   LV E ++    + ++  L    + + +Y++L  + + H
Sbjct: 82  NIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLH 141

Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQM 208
           S GI+HRD+KP N+++  +   L+++D+GLA            V +RY++ PE+++    
Sbjct: 142 SAGIIHRDLKPSNIVVKSDC-TLKILDFGLARTASTNFMMTPYVVTRYYRAPEVILGM-G 199

Query: 209 YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLY-----DYIDKYNI 263
           Y  ++D+WS+GC++  ++      F G D+ DQ  ++ + LGT             +  +
Sbjct: 200 YKENVDIWSVGCIMGELVKGSV-IFQGTDHIDQWNKVIEQLGTPSAEFMAALQPTVRNYV 258

Query: 264 ELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323
           E  P +  I        W     SE   + + +A D L K+L  D   R++  EA+ HPY
Sbjct: 259 ENRPAYPGIAFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPY 318

Query: 324 F 324
            
Sbjct: 319 I 319


>1UA2-A nrPDB
          Length = 346

 Score =  271 bits (692), Expect = 4e-73,   Method: Composition-based stats.
 Identities = 96/340 (28%), Positives = 163/340 (47%), Gaps = 36/340 (10%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIK--------REIKILENLR 89
            Y+ +  LG G+++ V++A +   N+ V +K +K   + + K        REIK+L+ L 
Sbjct: 11  RYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS 70

Query: 90  GGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ----TLTDYDIRFYMYEILKALD 145
             PNII L D          +LVF+ +  TD + + +     LT   I+ YM   L+ L+
Sbjct: 71  H-PNIIGLLDAFGHKS--NISLVFDFME-TDLEVIIKDNSLVLTPSHIKAYMLMTLQGLE 126

Query: 146 YCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFY-HPGQEYNVRVASRYFKGPELLV 204
           Y H   I+HRD+KP+N+++D E+  L+L D+GLA+ +  P + Y  +V +R+++ PELL 
Sbjct: 127 YLHQHWILHRDLKPNNLLLD-ENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLF 185

Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIE 264
             +MY   +DMW++GC+LA ++ R  PF  G  + DQL RI + LGT     + D  ++ 
Sbjct: 186 GARMYGVGVDMWAVGCILAELLLR-VPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLP 244

Query: 265 LDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324
               F         K +              + LD +  L  ++  +R+TA +A++  YF
Sbjct: 245 DYVTF---------KSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYF 295

Query: 325 YTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPL 364
                          PG   P  +  + +          +
Sbjct: 296 S--------NRPGPTPGCQLPRPNCPVETLKEQSNPALAI 327


>5U6Y-A nrPDB
          Length = 461

 Score =  271 bits (692), Expect = 5e-73,   Method: Composition-based stats.
 Identities = 73/298 (24%), Positives = 133/298 (44%), Gaps = 49/298 (16%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK-----KKKIKREIKILENLRGGPN 93
           YQL  +LG+G +S V   + +   ++   KI+   K      +K++RE +I   L+  PN
Sbjct: 2   YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKH-PN 60

Query: 94  IITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCHSM 150
           I+ L D + +       L+F+ V   +  +     +  ++ D    + +IL+A+ +CH M
Sbjct: 61  IVRLHDSISEEGHH--YLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQM 118

Query: 151 GIMHRDVKPHNVMIDH--EHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLVDYQ 207
           G++HRD+KP N+++    +   ++L D+GLA E     Q +     +  +  PE+L    
Sbjct: 119 GVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRK-D 177

Query: 208 MYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDP 267
            Y   +D+W+ G +L  ++    PF+    +               LY  I     +   
Sbjct: 178 PYGKPVDLWACGVILYILLVGYPPFWDEDQH--------------RLYQQIKAGAYDFP- 222

Query: 268 RFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFY 325
                              S     V+PEA D ++K+L  +   R+TA EA++HP+  
Sbjct: 223 -------------------SPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWIS 261


>2V7O-A nrPDB
          Length = 336

 Score =  270 bits (691), Expect = 7e-73,   Method: Composition-based stats.
 Identities = 73/314 (23%), Positives = 139/314 (44%), Gaps = 49/314 (15%)

Query: 21  REYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK-----K 75
            E   ++S        DDYQL  +LG+G +S V   +  T  ++   KI+   K      
Sbjct: 15  TENLYFQSMATCTRFTDDYQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSARDH 74

Query: 76  KKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYD 132
           +K++RE +I   L+  PNI+ L D + +       LVF+ V   +  +     +  ++ D
Sbjct: 75  QKLEREARICRLLKH-PNIVRLHDSISEEGFH--YLVFDLVTGGELFEDIVAREYYSEAD 131

Query: 133 IRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHR--KLRLIDWGLA-EFYHPGQEYN 189
               +++IL+++++ H   I+HRD+KP N+++  + +   ++L D+GLA E     Q + 
Sbjct: 132 ASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWF 191

Query: 190 VRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVL 249
               +  +  PE+L     Y   +D+W+ G +L  ++    PF+    +           
Sbjct: 192 GFAGTPGYLSPEVLRK-DPYGKPVDIWACGVILYILLVGYPPFWDEDQH----------- 239

Query: 250 GTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDH 309
               LY  I     +                      S     V+PEA + ++++L  + 
Sbjct: 240 ---KLYQQIKAGAYDFP--------------------SPEWDTVTPEAKNLINQMLTINP 276

Query: 310 QSRLTAREAMEHPY 323
             R+TA +A++HP+
Sbjct: 277 AKRITADQALKHPW 290


>2J90-A nrPDB
          Length = 304

 Score =  270 bits (690), Expect = 9e-73,   Method: Composition-based stats.
 Identities = 77/313 (24%), Positives = 140/313 (44%), Gaps = 53/313 (16%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP---------VKKKKIKREIKILE 86
           +D Y++  +LG G+++ V +       ++   K +K          V +++I+RE+ IL 
Sbjct: 25  EDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILR 84

Query: 87  NLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKA 143
            +R  PNIITL DI ++       L+ E V+  +        ++LT+ +   ++ +IL  
Sbjct: 85  EIRH-PNIITLHDIFENKTD--VVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDG 141

Query: 144 LDYCHSMGIMHRDVKPHNVMI---DHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGP 200
           + Y HS  I H D+KP N+M+   +  + +++LID+G+A     G E+     +  F  P
Sbjct: 142 VHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFVAP 201

Query: 201 ELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDK 260
           E +V+Y+      DMWS+G +   ++    PF  G    + L  I+ V            
Sbjct: 202 E-IVNYEPLGLEADMWSIGVITYILLSGASPFL-GETKQETLTNISAV------------ 247

Query: 261 YNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAME 320
            N + D  +                        S  A DF+ +LL  D + R+T  +++E
Sbjct: 248 -NYDFDEEY--------------------FSNTSELAKDFIRRLLVKDPKRRMTIAQSLE 286

Query: 321 HPYFYTVVKDQAR 333
           H +   + +   R
Sbjct: 287 HSWIKAIRRRNVR 299


>2YAB-A nrPDB
          Length = 361

 Score =  269 bits (688), Expect = 1e-72,   Method: Composition-based stats.
 Identities = 79/324 (24%), Positives = 141/324 (43%), Gaps = 53/324 (16%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK---------KKKIKREIKILE 86
           +D Y +  +LG G+++ V +    +   +   K +K  +         +++I+RE+ IL 
Sbjct: 11  EDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIEREVSILR 70

Query: 87  NLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKA 143
            +   PNIITL D+ ++       L+ E V+  +        ++L++ +   ++ +IL  
Sbjct: 71  QVLH-PNIITLHDVYENRTD--VVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDG 127

Query: 144 LDYCHSMGIMHRDVKPHNVMIDHEHR---KLRLIDWGLAEFYHPGQEYNVRVASRYFKGP 200
           ++Y H+  I H D+KP N+M+  ++     ++LID+GLA     G E+     +  F  P
Sbjct: 128 VNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAP 187

Query: 201 ELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDK 260
           E +V+Y+      DMWS+G +   ++    PF  G    + L  I  V            
Sbjct: 188 E-IVNYEPLGLEADMWSIGVITYILLSGASPFL-GDTKQETLANITAV------------ 233

Query: 261 YNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAME 320
            + + D  F                        S  A DF+ KLL  + + RLT +EA+ 
Sbjct: 234 -SYDFDEEF--------------------FSQTSELAKDFIRKLLVKETRKRLTIQEALR 272

Query: 321 HPYFYTVVKDQARMGSSSMPGGST 344
           HP+   V   QA +   S+     
Sbjct: 273 HPWITPVDTQQAMVRRESVVNLEN 296


>5Y86-A nrPDB
          Length = 588

 Score =  269 bits (688), Expect = 2e-72,   Method: Composition-based stats.
 Identities = 94/404 (23%), Positives = 179/404 (44%), Gaps = 77/404 (19%)

Query: 17  THRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK- 75
            H PR++  Y            Y++++ +G+G + +V    +    + V +K+++  K+ 
Sbjct: 198 IHVPRDHLAY-----------RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRF 246

Query: 76  -KKIKREIKILENLR-----GGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT-- 127
            ++   EI+ILE+L+     G  N+I + +           + FE ++  D  +L +   
Sbjct: 247 HRQAAEEIRILEHLKKQDKTGSMNVIHMLESFT--FRNHVCMAFELLS-IDLYELIKKNK 303

Query: 128 ---LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHR-KLRLIDWGLAEFYH 183
               +   +R +   IL++LD  H   I+H D+KP N+++ H  R   ++ID+G + F +
Sbjct: 304 FQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEY 363

Query: 184 PGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLV 243
             Q+    + SR+++ PE+++  + Y   +D+WS GC+LA ++  + P F G D  DQL 
Sbjct: 364 --QKLYTYIQSRFYRAPEIILGSR-YSTPIDIWSFGCILAELLTGQ-PLFPGEDEGDQLA 419

Query: 244 RIAKVLGTEDLYDYIDK------YNIELDPRFNDILGR--------------------HS 277
            + ++LG                 N +  PR+  +  +                      
Sbjct: 420 CMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPG 479

Query: 278 RKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSS 337
            K W   +   + +L     ++FL + L +D  +RLT  +A+ HP+            S 
Sbjct: 480 SKDWGTALKGCDDYL----FIEFLKRCLHWDPSARLTPAQALRHPWI-----------SK 524

Query: 338 SMPGGSTPVSSANMMSGISSVPTPSPLGPLAG--SPVIAAANPL 379
           S+P    P+++ + +SG   V   S    L     PV+  AN L
Sbjct: 525 SVP---RPLTTIDKVSGKRVVNPASAFQGLGSKLPPVVGIANKL 565


>3MIA-A nrPDB
          Length = 351

 Score =  269 bits (688), Expect = 2e-72,   Method: Composition-based stats.
 Identities = 93/357 (26%), Positives = 164/357 (45%), Gaps = 38/357 (10%)

Query: 25  DYESHVVEWGNQ-DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK-----I 78
            Y+S    + ++   Y+ + K+G+G + EVF+A +    +KV +K +    +K+      
Sbjct: 4   QYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITA 63

Query: 79  KREIKILENLRGGPNIITLADIVKDPVSRT------PALVFEHVNN---TDFKQLYQTLT 129
            REIKIL+ L+   N++ L +I +   S          LVF+   +        +    T
Sbjct: 64  LREIKILQLLKH-ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFT 122

Query: 130 DYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ--- 186
             +I+  M  +L  L Y H   I+HRD+K  NV+I  +   L+L D+GLA  +   +   
Sbjct: 123 LSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDG-VLKLADFGLARAFSLAKNSQ 181

Query: 187 --EYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVR 244
              Y  RV + +++ PELL+  + Y   +D+W  GC++A M  R  P   G+    QL  
Sbjct: 182 PNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTR-SPIMQGNTEQHQLAL 240

Query: 245 IAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKL 304
           I+++ G+     + +  N EL  +   + G+  + +          ++  P ALD +DKL
Sbjct: 241 ISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVK-----DRLKAYVRDPYALDLIDKL 295

Query: 305 LRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTP 361
           L  D   R+ + +A+ H +F+          S  MP     + S ++ S    +  P
Sbjct: 296 LVLDPAQRIDSDDALNHDFFW----------SDPMPSDLKGMLSTHLTSMFEYLAPP 342


>1JNK-A nrPDB
          Length = 423

 Score =  269 bits (687), Expect = 2e-72,   Method: Composition-based stats.
 Identities = 79/331 (23%), Positives = 151/331 (45%), Gaps = 20/331 (6%)

Query: 9   ARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVK 68
           A+ Y    +    +++  E     +     YQ ++ +G G    V  A +   +  V +K
Sbjct: 34  AKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIK 93

Query: 69  ILKP-----VKKKKIKREIKILENLRGGPNIITLADIVKD----PVSRTPALVFEHVNNT 119
            L          K+  RE+ +L       NII+L ++          +   LV E ++  
Sbjct: 94  KLSRPFQNQTHAKRAYREL-VLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN 152

Query: 120 DFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA 179
             + +   L    + + +Y++L  + + HS GI+HRD+KP N+++  +   L+++D+GLA
Sbjct: 153 LCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDC-TLKILDFGLA 211

Query: 180 EFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNY 239
                       V +RY++ PE+++    Y  ++D+WS+GC++  M+ R +  F G D  
Sbjct: 212 RTAGTSFMMTPYVVTRYYRAPEVILGM-GYKENVDIWSVGCIMGEMV-RHKILFPGRDYI 269

Query: 240 DQLVRIAKVLGTEDLYDYIDKYNI------ELDPRFNDILGRHSRKRWERFVHSENQHLV 293
           DQ  ++ + LGT    +++ K         E  P++  +              SE+  L 
Sbjct: 270 DQWNKVIEQLGTP-CPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLK 328

Query: 294 SPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324
           + +A D L K+L  D   R++  +A++HPY 
Sbjct: 329 ASQARDLLSKMLVIDPAKRISVDDALQHPYI 359


>2VZ6-A nrPDB
          Length = 313

 Score =  269 bits (687), Expect = 2e-72,   Method: Composition-based stats.
 Identities = 74/301 (24%), Positives = 134/301 (44%), Gaps = 49/301 (16%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK-----KKKIKREIKILENLRG 90
           Q  YQL  +LG+G +S V   + +   ++   KI+   K      +K++RE +I   L+ 
Sbjct: 21  QSMYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKH 80

Query: 91  GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYC 147
            PNI+ L D + +       L+F+ V   +  +     +  ++ D    + +IL+A+ +C
Sbjct: 81  -PNIVRLHDSISEEGHH--YLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHC 137

Query: 148 HSMGIMHRDVKPHNVMIDH--EHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLV 204
           H MG++HRD+KP N+++    +   ++L D+GLA E     Q +     +  +  PE+L 
Sbjct: 138 HQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLR 197

Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIE 264
               Y   +D+W+ G +L  ++    PF+    +               LY  I     +
Sbjct: 198 K-DPYGKPVDLWACGVILYILLVGYPPFWDEDQH--------------RLYQQIKAGAYD 242

Query: 265 LDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324
                                 S     V+PEA D ++K+L  +   R+TA EA++HP+ 
Sbjct: 243 FP--------------------SPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWI 282

Query: 325 Y 325
            
Sbjct: 283 S 283


>2XS0-A nrPDB
          Length = 386

 Score =  268 bits (686), Expect = 2e-72,   Method: Composition-based stats.
 Identities = 79/319 (24%), Positives = 143/319 (44%), Gaps = 21/319 (6%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP-----VKKKKIKREIKILENLRGGP 92
            YQ ++ +G G    V  A +      V +K L          K+  RE+ +L       
Sbjct: 27  RYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYREL-VLMKCVNHK 85

Query: 93  NIITLADIVKDPVS----RTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCH 148
           NII L ++     S    +   +V E ++    + +   L    + + +Y++L  + + H
Sbjct: 86  NIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLH 145

Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQM 208
           S GI+HRD+KP N+++  +   L+++D+GLA            V +RY++ PE+++    
Sbjct: 146 SAGIIHRDLKPSNIVVKSDC-TLKILDFGLARTAGTSFMMVPFVVTRYYRAPEVILGM-G 203

Query: 209 YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNI----- 263
           Y  ++D+WS+GC++  MI      F G D+ DQ  ++ + LGT    +++ K        
Sbjct: 204 YKENVDIWSVGCIMGEMIKGGV-LFPGTDHIDQWNKVIEQLGTP-CPEFMKKLQPTVRTY 261

Query: 264 -ELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHP 322
            E  P++                 SE+  L + +A D L K+L  D   R++  EA++HP
Sbjct: 262 VENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHP 321

Query: 323 YFYT-VVKDQARMGSSSMP 340
           Y        +A      +P
Sbjct: 322 YINVWYDPSEAEAPPPKIP 340


>3FI2-A nrPDB
          Length = 353

 Score =  268 bits (685), Expect = 3e-72,   Method: Composition-based stats.
 Identities = 76/302 (25%), Positives = 142/302 (47%), Gaps = 20/302 (6%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP-----VKKKKIKREIKILENLRGGP 92
            YQ ++ +G G    V  A +   +  V +K L          K+  RE+ +L       
Sbjct: 25  RYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYREL-VLMKCVNHK 83

Query: 93  NIITLADIVKD----PVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCH 148
           NII+L ++          +   LV E ++    + +   L    + + +Y++L  + + H
Sbjct: 84  NIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLH 143

Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQM 208
           S GI+HRD+KP N+++  +   L+++D+GLA            V +RY++ PE+++    
Sbjct: 144 SAGIIHRDLKPSNIVVKSDC-TLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGM-G 201

Query: 209 YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNI----- 263
           Y  ++D+WS+GC++  M+ R +  F G D  DQ  ++ + LGT    +++ K        
Sbjct: 202 YKENVDIWSVGCIMGEMV-RHKILFPGRDYIDQWNKVIEQLGTP-CPEFMKKLQPTVRNY 259

Query: 264 -ELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHP 322
            E  P++  +              SE+  L + +A D L K+L  D   R++  +A++HP
Sbjct: 260 VENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHP 319

Query: 323 YF 324
           Y 
Sbjct: 320 YI 321


>2A27-A nrPDB
          Length = 321

 Score =  268 bits (684), Expect = 4e-72,   Method: Composition-based stats.
 Identities = 78/324 (24%), Positives = 140/324 (43%), Gaps = 53/324 (16%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP---------VKKKKIKREIKILE 86
           +D Y +  +LG G+++ V +    +   +   K +K          V +++I+RE+ IL 
Sbjct: 11  EDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILR 70

Query: 87  NLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKA 143
            +    N+ITL D+ ++       L+ E V+  +        ++L++ +   ++ +IL  
Sbjct: 71  QVLHH-NVITLHDVYENRTD--VVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDG 127

Query: 144 LDYCHSMGIMHRDVKPHNVMIDHEHR---KLRLIDWGLAEFYHPGQEYNVRVASRYFKGP 200
           ++Y H+  I H D+KP N+M+  ++     ++LID+GLA     G E+     +  F  P
Sbjct: 128 VNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAP 187

Query: 201 ELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDK 260
           E +V+Y+      DMWS+G +   ++    PF  G    + L  I  V            
Sbjct: 188 E-IVNYEPLGLEADMWSIGVITYILLSGASPFL-GDTKQETLANITAV------------ 233

Query: 261 YNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAME 320
            + + D  F                        S  A DF+ KLL  + + RLT +EA+ 
Sbjct: 234 -SYDFDEEF--------------------FSQTSELAKDFIRKLLVKETRKRLTIQEALR 272

Query: 321 HPYFYTVVKDQARMGSSSMPGGST 344
           HP+   V   QA +   S+     
Sbjct: 273 HPWITPVDNQQAMVRRESVVNLEN 296


>3BHH-A nrPDB
          Length = 295

 Score =  268 bits (684), Expect = 4e-72,   Method: Composition-based stats.
 Identities = 71/298 (23%), Positives = 134/298 (44%), Gaps = 49/298 (16%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK-----KKKIKREIKILENLRGG 91
           D+YQL   +G+G +S V   + +    +   KI+   K      +K++RE +I   L+  
Sbjct: 4   DEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHS 63

Query: 92  PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCH 148
            NI+ L D + +       LVF+ V   +  +     +  ++ D    + +IL+A+ +CH
Sbjct: 64  -NIVRLHDSISEEGFH--YLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCH 120

Query: 149 SMGIMHRDVKPHNVMIDHEHR--KLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLVD 205
            MG++HRD+KP N+++  + +   ++L D+GLA E     Q +     +  +  PE+L  
Sbjct: 121 QMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRK 180

Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIEL 265
            + Y   +D+W+ G +L  ++    PF+    +               LY  I     + 
Sbjct: 181 -EAYGKPVDIWACGVILYILLVGYPPFWDEDQH--------------KLYQQIKAGAYDF 225

Query: 266 DPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323
                                S     V+PEA + ++++L  +   R+TA EA++HP+
Sbjct: 226 P--------------------SPEWDTVTPEAKNLINQMLTINPAKRITAHEALKHPW 263


>3PG1-A nrPDB
          Length = 362

 Score =  268 bits (684), Expect = 4e-72,   Method: Composition-based stats.
 Identities = 83/313 (26%), Positives = 147/313 (46%), Gaps = 31/313 (9%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL--------------KPVKKKKIKRE 81
           Q  Y + R +  G Y  V   ++      V +K +                   K++ RE
Sbjct: 21  QSPYTVQRFISSGSYGAVCAGVDSE-GIPVAIKRVFNTVSDGRTVNILSDSFLCKRVLRE 79

Query: 82  IKILENLRGGPNIITLADIV---KDPVSRTPALVFEHVNNTDFKQLYQ----TLTDYDIR 134
           I++L +    PNI+ L DI    ++P      LV E +  TD  Q+       ++   I+
Sbjct: 80  IRLLNHF-HHPNILGLRDIFVHFEEPAMHKLYLVTELM-RTDLAQVIHDQRIVISPQHIQ 137

Query: 135 FYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVAS 194
           ++MY IL  L   H  G++HRD+ P N+++  ++  + + D+ LA            V  
Sbjct: 138 YFMYHILLGLHVLHEAGVVHRDLHPGNILL-ADNNDITICDFNLAREDTADANKTHYVTH 196

Query: 195 RYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDL 254
           R+++ PEL++ ++ +   +DMWS GC++A M  RK   F G   Y+QL +I +V+GT  +
Sbjct: 197 RWYRAPELVMQFKGFTKLVDMWSAGCVMAEMFNRKA-LFRGSTFYNQLNKIVEVVGTPKI 255

Query: 255 YDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT 314
            D +   +        + L     + W   V + +     P ALD + K+L ++ Q R++
Sbjct: 256 EDVVMFSSPSARDYLRNSLSNVPARAWTAVVPTAD-----PVALDLIAKMLEFNPQRRIS 310

Query: 315 AREAMEHPYFYTV 327
             +A+ HPYF ++
Sbjct: 311 TEQALRHPYFESL 323


>4NIF-A nrPDB
          Length = 333

 Score =  266 bits (681), Expect = 9e-72,   Method: Composition-based stats.
 Identities = 86/346 (24%), Positives = 149/346 (43%), Gaps = 48/346 (13%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIIT 96
           D Y +   +G G YSE    ++   N +  VK++   K+   + EI+IL      PNIIT
Sbjct: 8   DGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSE-EIEILLRYGQHPNIIT 66

Query: 97  LADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCHSMGIM 153
           L D+  D   +   LV E +   +        +  ++ +  F ++ I K ++Y HS G++
Sbjct: 67  LKDVYDD--GKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVV 124

Query: 154 HRDVKPHNVMIDHEHRK---LRLIDWGLAEFYH-PGQEYNVRVASRYFKGPELLVDYQMY 209
           HRD+KP N++   E      LR+ D+G A+              +  F  PE+L   Q Y
Sbjct: 125 HRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVL-KRQGY 183

Query: 210 DYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRF 269
           D   D+WSLG +L +M+    PF +G  +  +                            
Sbjct: 184 DEGCDIWSLGILLYTMLAGYTPFANGPSDTPE---------------------------- 215

Query: 270 NDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 329
            +IL R    ++   +   N + VS  A D + K+L  D   RLTA++ ++HP+    V 
Sbjct: 216 -EILTRIGSGKFT--LSGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPW----VT 268

Query: 330 DQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLGPLAGSPVIAA 375
            + ++  S +      +    M +  S++ +  P   L   P+ ++
Sbjct: 269 QKDKLPQSQLSHQDLQLVKGAMAATYSALNSSKPTPQL--KPIESS 312


>3SOA-A nrPDB
          Length = 444

 Score =  266 bits (680), Expect = 1e-71,   Method: Composition-based stats.
 Identities = 71/300 (23%), Positives = 133/300 (44%), Gaps = 49/300 (16%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVV-----KILKPVKKKKIKREIKILENLRGG 91
           ++YQL  +LG+G +S V   + +   ++        K L     +K++RE +I   L+  
Sbjct: 11  EEYQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDHQKLEREARICRLLKH- 69

Query: 92  PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCH 148
           PNI+ L D + +       L+F+ V   +  +     +  ++ D    + +IL+A+ +CH
Sbjct: 70  PNIVRLHDSISEEGHH--YLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCH 127

Query: 149 SMGIMHRDVKPHNVMIDH--EHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLVD 205
            MG++HR++KP N+++    +   ++L D+GLA E     Q +     +  +  PE+L  
Sbjct: 128 QMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRK 187

Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIEL 265
              Y   +D+W+ G +L  ++    PF+    +               LY  I     + 
Sbjct: 188 -DPYGKPVDLWACGVILYILLVGYPPFWDEDQH--------------RLYQQIKAGAYDF 232

Query: 266 DPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFY 325
                                S     V+PEA D ++K+L  +   R+TA EA++HP+  
Sbjct: 233 P--------------------SPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWIS 272


>2JC6-A nrPDB
          Length = 334

 Score =  265 bits (678), Expect = 2e-71,   Method: Composition-based stats.
 Identities = 73/310 (23%), Positives = 131/310 (42%), Gaps = 51/310 (16%)

Query: 24  WDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPV----KKKKIK 79
           W  ++  ++      ++    LG G +SEV  A      +   VK +       K+  I+
Sbjct: 13  WKKQAEDIKKI----FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIE 68

Query: 80  REIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTD-FKQLYQT--LTDYDIRFY 136
            EI +L  ++   NI+ L DI + P      LV + V+  + F ++ +    T+ D    
Sbjct: 69  NEIAVLRKIKH-ENIVALEDIYESP--NHLYLVMQLVSGGELFDRIVEKGFYTEKDASTL 125

Query: 137 MYEILKALDYCHSMGIMHRDVKPHNVMI--DHEHRKLRLIDWGLAEFYHPGQEYNVRVAS 194
           + ++L A+ Y H MGI+HRD+KP N++     E  K+ + D+GL++    G   +    +
Sbjct: 126 IRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGT 185

Query: 195 RYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDL 254
             +  PE+L   + Y  ++D WS+G +   ++    PF+  +D+               L
Sbjct: 186 PGYVAPEVLAQ-KPYSKAVDCWSIGVIAYILLCGYPPFYDENDS--------------KL 230

Query: 255 YDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT 314
           ++ I K   E D  +                       +S  A DF+  L+  D   R T
Sbjct: 231 FEQILKAEYEFDSPY--------------------WDDISDSAKDFIRNLMEKDPNKRYT 270

Query: 315 AREAMEHPYF 324
             +A  HP+ 
Sbjct: 271 CEQAARHPWI 280


>5G6V-A nrPDB
          Length = 324

 Score =  265 bits (678), Expect = 2e-71,   Method: Composition-based stats.
 Identities = 80/312 (25%), Positives = 165/312 (52%), Gaps = 22/312 (7%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK----KIKREIKILENLRGG 91
            + Y  + KLG G Y+ V++  +   +  V +K ++   ++       RE+ +L++L+  
Sbjct: 1   METYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHA 60

Query: 92  PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY----QTLTDYDIRFYMYEILKALDYC 147
            NI+TL DI+     ++  LVFE+++  D KQ        +  ++++ +++++L+ L YC
Sbjct: 61  -NIVTLHDIIH--TEKSLTLVFEYLDK-DLKQYLDDCGNIINMHNVKLFLFQLLRGLAYC 116

Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH-PGQEYNVRVASRYFKGPELLVDY 206
           H   ++HRD+KP N++I+ E  +L+L D+GLA     P + Y+  V + +++ P++L+  
Sbjct: 117 HRQKVLHRDLKPQNLLIN-ERGELKLADFGLARAKSIPTKTYDNEVVTLWYRPPDILLGS 175

Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 266
             Y   +DMW +GC+   M   + P F G    +QL  I ++LGT     +    + E  
Sbjct: 176 TDYSTQIDMWGVGCIFYEMATGR-PLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEF 234

Query: 267 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYT 326
             +N         ++       +   +  +  D L KLL+++ ++R++A +AM+HP+F +
Sbjct: 235 KTYN-------YPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLS 287

Query: 327 VVKDQARMGSSS 338
           + +   ++  ++
Sbjct: 288 LGERIHKLPDTT 299


>3GC0-A nrPDB
          Length = 329

 Score =  265 bits (678), Expect = 2e-71,   Method: Composition-based stats.
 Identities = 83/302 (27%), Positives = 154/302 (50%), Gaps = 25/302 (8%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK-----IKREIKILENLRGG 91
           D Y+ + KLG G Y EV++AI+   NE V +K ++   +++       RE+ +L+ L+  
Sbjct: 34  DRYRRITKLGEGTYGEVYKAIDTVTNETVAIKRIRLEHEEEGVPGTAIREVSLLKELQH- 92

Query: 92  PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYCH 148
            NII L  ++    +    L+FE+  N D K+       ++   I+ ++Y+++  +++CH
Sbjct: 93  RNIIELKSVIHH--NHRLHLIFEYAEN-DLKKYMDKNPDVSMRVIKSFLYQLINGVNFCH 149

Query: 149 SMGIMHRDVKPHNVMID----HEHRKLRLIDWGLAEFYH-PGQEYNVRVASRYFKGPELL 203
           S   +HRD+KP N+++      E   L++ D+GLA  +  P +++   + + +++ PE+L
Sbjct: 150 SRRCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQFTHEIITLWYRPPEIL 209

Query: 204 VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNI 263
           +  + Y  S+D+WS+ C+ A M+  K P F G    DQL +I +VLG  D   +     +
Sbjct: 210 LGSRHYSTSVDIWSIACIWAEMLM-KTPLFPGDSEIDQLFKIFEVLGLPDDTTWPG---V 265

Query: 264 ELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323
              P +     +   K  +R + +                +L  D   R++A+ A+EHPY
Sbjct: 266 TALPDWKQSFPKFRGKTLKRVLGALLDDEGLDLLT----AMLEMDPVKRISAKNALEHPY 321

Query: 324 FY 325
           F 
Sbjct: 322 FS 323


>5WAX-A nrPDB
          Length = 310

 Score =  264 bits (674), Expect = 6e-71,   Method: Composition-based stats.
 Identities = 70/337 (20%), Positives = 136/337 (40%), Gaps = 41/337 (12%)

Query: 35  NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK--KKIKREIKILENLRGGP 92
           + D Y+LVR +G G +       N  + + V VK ++  +K  + ++REI    +LR  P
Sbjct: 9   DGDRYELVRDIGSGNFGVARLMRNRADGQLVAVKYIERGEKIDENVQREIINHRSLRH-P 67

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCHS 149
           NII   +++  P     A+V E+ +  +  +        ++ + RF+  +++  + YCHS
Sbjct: 68  NIIRFKEVILTPT--HLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHS 125

Query: 150 MGIMHRDVKPHNVMIDHEHR-KLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQM 208
           M + HRD+K  N ++D     +L++ D+G ++      +    V +  +  PE+L+  + 
Sbjct: 126 MQVCHRDLKLENTLLDGSTAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEY 185

Query: 209 YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPR 268
                D+WS G  L  M+    PF    +  +    I ++LG +                
Sbjct: 186 DGKVADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRILGVQ---------------- 229

Query: 269 FNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVV 328
                               +   +SPE  D + ++   +  +R+T  E   HP+F   +
Sbjct: 230 ----------------YSIPDYVHISPECQDLISRIFVANPATRITIPEIRNHPWFLKNL 273

Query: 329 KDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLG 365
                  S+       P      M  I  +   + + 
Sbjct: 274 PADLMDDSTMSKQYEEPEQPMQSMDEIMQILAEATIP 310


>2X4F-A nrPDB
          Length = 373

 Score =  264 bits (674), Expect = 6e-71,   Method: Composition-based stats.
 Identities = 79/334 (23%), Positives = 146/334 (43%), Gaps = 49/334 (14%)

Query: 4   PVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDY---QLVRKLGRGKYSEVFEAINIT 60
           PV S+      V+   P   +D+     + G  + +        LG G++ +V +     
Sbjct: 53  PVKSKRTSALAVDIPAPPAPFDHRIVTAKQGAVNSFYTVSKTEILGGGRFGQVHKCEETA 112

Query: 61  NNEKVVVKILKP---VKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVN 117
              K+  KI+K      K+++K EI ++  L    N+I L D  +        LV E+V+
Sbjct: 113 TGLKLAAKIIKTRGMKDKEEVKNEISVMNQLDHA-NLIQLYDAFESKND--IVLVMEYVD 169

Query: 118 NTDFKQLY----QTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVM-IDHEHRKLR 172
             +           LT+ D   +M +I + + + H M I+H D+KP N++ ++ + ++++
Sbjct: 170 GGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQMYILHLDLKPENILCVNRDAKQIK 229

Query: 173 LIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPF 232
           +ID+GLA  Y P ++  V   +  F  PE++ +Y    +  DMWS+G +   ++    PF
Sbjct: 230 IIDFGLARRYKPREKLKVNFGTPEFLAPEVV-NYDFVSFPTDMWSVGVIAYMLLSGLSPF 288

Query: 233 FHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHL 292
             G ++ + L  I                                  RW+  +  E    
Sbjct: 289 L-GDNDAETLNNIL-------------------------------ACRWD--LEDEEFQD 314

Query: 293 VSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYT 326
           +S EA +F+ KLL  +   R++A EA++HP+   
Sbjct: 315 ISEEAKEFISKLLIKEKSWRISASEALKHPWLSD 348


>1ZWS-A nrPDB
          Length = 288

 Score =  263 bits (673), Expect = 8e-71,   Method: Composition-based stats.
 Identities = 77/314 (24%), Positives = 138/314 (43%), Gaps = 53/314 (16%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP---------VKKKKIKREIKILE 86
           +D Y +  +LG G+++ V +    +   +   K +K          V +++I+RE+ IL 
Sbjct: 11  EDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILR 70

Query: 87  NLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKA 143
            +    N+ITL D+ ++       L+ E V+  +        ++L++ +   ++ +IL  
Sbjct: 71  QVLHH-NVITLHDVYENRTD--VVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDG 127

Query: 144 LDYCHSMGIMHRDVKPHNVMIDHEHR---KLRLIDWGLAEFYHPGQEYNVRVASRYFKGP 200
           ++Y H+  I H D+KP N+M+  ++     ++LID+GLA     G E+     +  F  P
Sbjct: 128 VNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAP 187

Query: 201 ELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDK 260
           E +V+Y+      DMWS+G +   ++    PF  G    + L  I  V            
Sbjct: 188 E-IVNYEPLGLEADMWSIGVITYILLSGASPFL-GDTKQETLANITSV------------ 233

Query: 261 YNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAME 320
            + + D  F                        S  A DF+ KLL  + + RLT +EA+ 
Sbjct: 234 -SYDFDEEF--------------------FSHTSELAKDFIRKLLVKETRKRLTIQEALR 272

Query: 321 HPYFYTVVKDQARM 334
           HP+   V   QA +
Sbjct: 273 HPWITPVDNQQAMV 286


>4FG9-A nrPDB
          Length = 320

 Score =  263 bits (672), Expect = 1e-70,   Method: Composition-based stats.
 Identities = 71/298 (23%), Positives = 132/298 (44%), Gaps = 47/298 (15%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK----KIKREIKILENLRGG 91
           +D Y     LG G +SEV  A +    + V +K +     +     ++ EI +L  ++  
Sbjct: 17  RDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMENEIAVLHKIKH- 75

Query: 92  PNIITLADIVKDPVSRTPALVFEHVNNTD-FKQLYQT--LTDYDIRFYMYEILKALDYCH 148
           PNI+ L DI +        L+ + V+  + F ++ +    T+ D    ++++L A+ Y H
Sbjct: 76  PNIVALDDIYES--GGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLH 133

Query: 149 SMGIMHRDVKPHNVMIDH--EHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDY 206
            +GI+HRD+KP N++     E  K+ + D+GL++   PG   +    +  +  PE+L   
Sbjct: 134 DLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEVLAQ- 192

Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 266
           + Y  ++D WS+G +   ++    PF+  +D                L++ I K   E D
Sbjct: 193 KPYSKAVDCWSIGVIAYILLCGYPPFYDEND--------------AKLFEQILKAEYEFD 238

Query: 267 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324
             +                       +S  A DF+  L+  D + R T  +A++HP+ 
Sbjct: 239 SPY--------------------WDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWI 276


>5IG1-A nrPDB
          Length = 344

 Score =  263 bits (671), Expect = 1e-70,   Method: Composition-based stats.
 Identities = 67/291 (23%), Positives = 126/291 (43%), Gaps = 48/291 (16%)

Query: 44  KLGRGKYSEVFEAINITNNEKVVVKIL-----KPVKKKKIKREIKILENLRGGPNIITLA 98
            +G+G +S V   +N    E   VK++     +  +  KIKREI I  +L+   +I+++ 
Sbjct: 24  VIGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRSSEINKIKREIGICSSLQH-EHIVSMR 82

Query: 99  DIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCHSMGIMHR 155
              +D       LVFE+V+  +        +   + D    M++IL AL +CHS  I+HR
Sbjct: 83  RAFRD--ESHFYLVFEYVSGGELFDEIVTRKFYNEKDASACMHQILSALQHCHSKNIIHR 140

Query: 156 DVKPHNVMIDHE--HRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSL 213
           D+KP N+++  +  +  +++ D+GLA     G  Y     +  +  PE++     YD ++
Sbjct: 141 DLKPENLLLASKDPNAPVKITDFGLAVIMEQGPTYFGFAGTPGYLSPEVIRRV-PYDTAV 199

Query: 214 DMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDIL 273
           D+W+ G +L  ++    PF+   D+     +I                            
Sbjct: 200 DVWACGVILYILLVGYPPFWE-EDHQKLYAQI---------------------------- 230

Query: 274 GRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324
                K  +    S     V+  A + +  +L  + + R T +E ++HP+ 
Sbjct: 231 -----KNCQYDFPSPEWDSVTTAAKELIKAMLEPNPKRRPTVQELLQHPWI 276


>2W4O-A nrPDB
          Length = 349

 Score =  263 bits (671), Expect = 1e-70,   Method: Composition-based stats.
 Identities = 76/293 (25%), Positives = 122/293 (41%), Gaps = 43/293 (14%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKR-EIKILENLRGGPNII 95
           D +++  +LGRG  S V+        +   +K+LK    KKI R EI +L  L   PNII
Sbjct: 53  DFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKIVRTEIGVLLRLSH-PNII 111

Query: 96  TLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCHSMGI 152
            L +I + P     +LV E V   +           ++ D    + +IL+A+ Y H  GI
Sbjct: 112 KLKEIFETPTE--ISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGI 169

Query: 153 MHRDVKPHNVMIDH--EHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYD 210
           +HRD+KP N++         L++ D+GL++             +  +  PE+L     Y 
Sbjct: 170 VHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGC-AYG 228

Query: 211 YSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFN 270
             +DMWS+G +   ++   EPF+    +     RI                         
Sbjct: 229 PEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILN----------------------- 265

Query: 271 DILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323
                      E +  S     VS  A D + KL+  D + RLT  +A++HP+
Sbjct: 266 ----------CEYYFISPWWDEVSLNAKDLVRKLIVLDPKKRLTTFQALQHPW 308


>3E3P-A nrPDB
          Length = 360

 Score =  262 bits (670), Expect = 2e-70,   Method: Composition-based stats.
 Identities = 89/350 (25%), Positives = 164/350 (46%), Gaps = 32/350 (9%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIK-REIKILENLR--GGP 92
            D +Q+ R  G+G +  V      +    V +K  K ++  + + RE++I+++L     P
Sbjct: 22  MDRFQVERMAGQGTFGTVQLGKEKSTGMSVAIK--KVIQDPRFRNRELQIMQDLAVLHHP 79

Query: 93  NIITLADIV-----KDPVSRTPALVFEHVNNTDFKQLYQTLTDYD-------IRFYMYEI 140
           NI+ L         +D       +V E+V +T   +  +             I+ +++++
Sbjct: 80  NIVQLQSYFYTLGERDRRDIYLNVVMEYVPDT-LHRCCRNYYRRQVAPPPILIKVFLFQL 138

Query: 141 LKALDYCH--SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFK 198
           ++++   H  S+ + HRD+KPHNV+++     L+L D+G A+   P +     + SRY++
Sbjct: 139 IRSIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKLSPSEPNVAYICSRYYR 198

Query: 199 GPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYI 258
            PEL+   Q Y  ++D+WS+GC+ A M+   EP F G ++  QL  I +VLG        
Sbjct: 199 APELIFGNQHYTTAVDIWSVGCIFAEMMLG-EPIFRGDNSAGQLHEIVRVLGCPS----- 252

Query: 259 DKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREA 318
            +   +L+P   D+   +S+      V S++    + EA D L  LL+Y  + R+   EA
Sbjct: 253 REVLRKLNPSHTDVDLYNSKGIPWSNVFSDHSLKDAKEAYDLLSALLQYLPEERMKPYEA 312

Query: 319 MEHPYFYTVVKDQARMGSSSMP-GGSTPVSSANMMSGISSVPTPSPLGPL 367
           + HPYF     D+    ++ +P     P      +     V + +    L
Sbjct: 313 LCHPYF-----DELHDPATKLPNNKDLPEDLFRFLPNEIEVMSEAQKAKL 357


>5ES1-A nrPDB
          Length = 328

 Score =  261 bits (667), Expect = 3e-70,   Method: Composition-based stats.
 Identities = 67/314 (21%), Positives = 138/314 (43%), Gaps = 51/314 (16%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL-----KPVKKKKIKREIKILENLRGGP 92
           +Y+L+R +G+G +++V  A +I    +V +KI+      P   +K+ RE++I++ L   P
Sbjct: 16  NYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGL-NHP 74

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNT---DFKQLYQTLTDYDIRFYMYEILKALDYCHS 149
           NI+ L ++++    +T  LV E+ +     D+   +  + + + R    +I+ A+ YCH 
Sbjct: 75  NIVKLFEVIE--TEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQ 132

Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMY 209
             I+HRD+K  N+++D E   +++ D+G +  +  G + +    S  +  PEL    +  
Sbjct: 133 KNIVHRDLKAENLLLDAE-ANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYD 191

Query: 210 DYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRF 269
              +D+WSLG +L +++    PF  GH+  +   R+ +            KY +      
Sbjct: 192 GPEVDIWSLGVILYTLVSGSLPF-DGHNLKELRERVLR-----------GKYRVPF---- 235

Query: 270 NDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 329
                                  +S +    L + L  +   R T  + M+  +   +  
Sbjct: 236 ----------------------YMSTDCESILRRFLVLNPAKRCTLEQIMKDKWI-NIGY 272

Query: 330 DQARMGSSSMPGGS 343
           +   +   + P   
Sbjct: 273 EGEELKPYTEPEED 286


>5XZW-A nrPDB
          Length = 471

 Score =  261 bits (667), Expect = 4e-70,   Method: Composition-based stats.
 Identities = 79/316 (25%), Positives = 133/316 (42%), Gaps = 58/316 (18%)

Query: 32  EWGNQDDYQLV-RKLGRGKYSEVFEAINITNNEKVVVKILKPVKK----KKIKREIKILE 86
           + G   D+ ++   +G+G ++ V +AI  T  +   VKI+   K       + RE+++L+
Sbjct: 190 KTGIFKDFSIIDEVVGQGAFATVKKAIERTTGKTFAVKIISKRKVIGNMDGVTRELEVLQ 249

Query: 87  NLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQL---YQTLTDYDIRFYMYEILKA 143
            L   P I+ L    +D  S    +V E V+  D       +  + +   R    +IL A
Sbjct: 250 KL-NHPRIVRLKGFYEDTESY--YMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTA 306

Query: 144 LDYCHSMGIMHRDVKPHNVMIDHEHRK-LRLIDWGLAEFYHPGQEYNVRVASRYFKGPEL 202
           + Y HSMGI HRD+KP N++I+ +    +++ D+GLA+    G        +  +  PE+
Sbjct: 307 IKYIHSMGISHRDLKPDNILIEQDDPVLVKITDFGLAKVQGNGSFMKTFCGTLAYVAPEV 366

Query: 203 LVD------------YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLG 250
           +                 Y   +DMWS+GC++  ++    PF       DQL        
Sbjct: 367 IRGKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPF--SGSTQDQL-------- 416

Query: 251 TEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQ 310
               Y  I + +    P                         +S EA DF+D LL+ D  
Sbjct: 417 ----YKQIGRGSYHEGP--------------------LKDFRISEEARDFIDSLLQVDPN 452

Query: 311 SRLTAREAMEHPYFYT 326
           +R TA +A+ HP+   
Sbjct: 453 NRSTAAKALNHPWIVD 468


>3F3Z-A nrPDB
          Length = 277

 Score =  261 bits (667), Expect = 4e-70,   Method: Composition-based stats.
 Identities = 74/295 (25%), Positives = 128/295 (43%), Gaps = 47/295 (15%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP---VKKKKIKREIKILENLRGGPNII 95
           Y L   +GRG + EV  A+      +   K +         + K+EI+I+++L   PNII
Sbjct: 11  YTLENTIGRGSWGEVKIAVQKGTRIRRAAKKIPKYFVEDVDRFKQEIEIMKSL-DHPNII 69

Query: 96  TLADIVKDPVSRTPALVFEHVNNTDFKQ---LYQTLTDYDIRFYMYEILKALDYCHSMGI 152
            L +  +D       LV E     +  +     +   + D    M ++L A+ YCH + +
Sbjct: 70  RLYETFEDNTD--IYLVMELCTGGELFERVVHKRVFRESDAARIMKDVLSAVAYCHKLNV 127

Query: 153 MHRDVKPHNVMI--DHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYD 210
            HRD+KP N +   D     L+LID+GLA  + PG+    +V + Y+  P++L     Y 
Sbjct: 128 AHRDLKPENFLFLTDSPDSPLKLIDFGLAARFKPGKMMRTKVGTPYYVSPQVLEGL--YG 185

Query: 211 YSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFN 270
              D WS G M+  ++    PF    D+ + +++I +   T    D+++           
Sbjct: 186 PECDEWSAGVMMYVLLCGYPPFSAPTDS-EVMLKIREGTFTFPEKDWLN----------- 233

Query: 271 DILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFY 325
                                 VSP+A   + +LL    + R+T+ +A+EH +F 
Sbjct: 234 ----------------------VSPQAESLIRRLLTKSPKQRITSLQALEHEWFE 266


>2YCR-A nrPDB
          Length = 323

 Score =  261 bits (666), Expect = 5e-70,   Method: Composition-based stats.
 Identities = 79/345 (22%), Positives = 127/345 (36%), Gaps = 55/345 (15%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK-----------KIKREIKI 84
           +D+Y + + LG G   EV  A      +KV +KI+   K              ++ EI+I
Sbjct: 9   RDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEI 68

Query: 85  LENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEIL 141
           L+ L   P II + +      +    +V E +   +        + L +   + Y Y++L
Sbjct: 69  LKKL-NHPCIIKIKNFFD---AEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQML 124

Query: 142 KALDYCHSMGIMHRDVKPHNVMIDH--EHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKG 199
            A+ Y H  GI+HRD+KP NV++    E   +++ D+G ++             +  +  
Sbjct: 125 LAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLA 184

Query: 200 PELLVDYQ--MYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDY 257
           PE+LV      Y+ ++D WSLG +L   +    PF                     L D 
Sbjct: 185 PEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQV-------------SLKDQ 231

Query: 258 IDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTARE 317
           I        P                    E    VS +ALD + KLL  D ++R T  E
Sbjct: 232 ITSGKYNFIP--------------------EVWAEVSEKALDLVKKLLVVDPKARFTTEE 271

Query: 318 AMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPS 362
           A+ HP+       +      S    ST           S      
Sbjct: 272 ALRHPWLQDEDMKRKFQDLLSEENESTAKPQVLAQPSTSRKRPRE 316


>3GUB-A nrPDB
          Length = 295

 Score =  260 bits (664), Expect = 9e-70,   Method: Composition-based stats.
 Identities = 76/319 (23%), Positives = 142/319 (44%), Gaps = 53/319 (16%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP---------VKKKKIKREIKILEN 87
           D Y    +LG G+++ V +    +   +   K +K          V ++ I+RE+ IL+ 
Sbjct: 11  DYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKE 70

Query: 88  LRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKAL 144
           ++  PN+ITL ++ ++       L+ E V   +        ++LT+ +   ++ +IL  +
Sbjct: 71  IQH-PNVITLHEVYENKTD--VILIGELVAGGELFDFLAEKESLTEEEATEFLKQILNGV 127

Query: 145 DYCHSMGIMHRDVKPHNVMI---DHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPE 201
            Y HS+ I H D+KP N+M+   +    ++++ID+GLA     G E+     +  F  PE
Sbjct: 128 YYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAPE 187

Query: 202 LLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKY 261
            +V+Y+      DMWS+G +   ++    PF  G    + L  ++ V      Y++ D+Y
Sbjct: 188 -IVNYEPLGLEADMWSIGVITYILLSGASPFL-GDTKQETLANVSAV-----NYEFEDEY 240

Query: 262 NIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEH 321
                                           S  A DF+ +LL  D + R+T +++++H
Sbjct: 241 ----------------------------FSNTSALAKDFIRRLLVKDPKKRMTIQDSLQH 272

Query: 322 PYFYTVVKDQARMGSSSMP 340
           P+       QA   + S P
Sbjct: 273 PWIKPKDTQQALSSAWSHP 291


>3RP9-A nrPDB
          Length = 458

 Score =  259 bits (663), Expect = 1e-69,   Method: Composition-based stats.
 Identities = 94/410 (22%), Positives = 162/410 (39%), Gaps = 84/410 (20%)

Query: 32  EWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL-----KPVKKKKIKREIKILE 86
           +W   D Y++   +G G Y  V EA +      V +K +       +  K+I REI IL 
Sbjct: 48  DWQIPDRYEIRHLIGTGSYGHVCEAYDKLEKRVVAIKKILRVFEDLIDCKRILREIAILN 107

Query: 87  NLRGGPNIITLADIV--KDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEIL 141
            L    +++ + DIV  KD        V   + ++DFK+L++T   LT+  I+  +Y +L
Sbjct: 108 RL-NHDHVVKVLDIVIPKDVEKFDELYVVLEIADSDFKKLFRTPVYLTELHIKTLLYNLL 166

Query: 142 KALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFY------------------- 182
             + Y HS GI+HRD+KP N +++ +   +++ D+GLA                      
Sbjct: 167 VGVKYVHSAGILHRDLKPANCLVNQDC-SVKVCDFGLARTVDYPENGNSQLPISPREDDM 225

Query: 183 ---------HPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFR----- 228
                    +  ++    V +R+++ PEL++  + Y  ++D+WS+GC+ A ++       
Sbjct: 226 NLVTFPHTKNLKRQLTGHVVTRWYRAPELILLQENYTEAIDVWSIGCIFAELLNMIKENV 285

Query: 229 -----KEPFFHGHD--------------------NYDQLVRIAKVLGTEDLYDYIDKYNI 263
                + P F G                      N DQL  I  +LGT    D       
Sbjct: 286 AYHADRGPLFPGSSCFPLSPDQKAGNDFKFHTRGNRDQLNVIFNILGTPSEEDIEALEKE 345

Query: 264 ELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323
           +          R      ERF  S      S +A+  L ++L ++   R+T  E + HP+
Sbjct: 346 DAKRYIRIFPKREGTDLAERFPAS------SADAIHLLKRMLVFNPNKRITINECLAHPF 399

Query: 324 FYTVVKDQARMGSS---SMP-----GGSTPVSSANMMSGISSVPTPSPLG 365
           F  V   +    ++    +P         P      +  I        L 
Sbjct: 400 FKEVRIAEVETNATEKVRLPFNDWMNMDEPQLRYAFVKEIQRYHPEIQLP 449


>4BGQ-A nrPDB
          Length = 304

 Score =  259 bits (663), Expect = 1e-69,   Method: Composition-based stats.
 Identities = 87/301 (28%), Positives = 148/301 (49%), Gaps = 21/301 (6%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK-----KKKIKREIKILENLRG 90
            + ++++  +G G Y  V +  +   +E V +K  K  +     K+   RE+K+L  L+ 
Sbjct: 11  MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 70

Query: 91  GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYC 147
             NI+ L +  +        LVFE+V     + L +    +    ++ Y+Y+++KA+ +C
Sbjct: 71  -ENIVELKEAFRR--RGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWC 127

Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ--EYNVRVASRYFKGPELLVD 205
           H   I+HRD+KP N++I H +  L+L D+G A     G    Y+  VA+R+++ PELL+ 
Sbjct: 128 HKNDIVHRDIKPENLLISH-NDVLKLCDFGFARNLSEGNNANYDEEVATRWYRSPELLLG 186

Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIEL 265
              Y  S+DMWS+GC+L  +   + P F G    DQL  I KVLG          Y+   
Sbjct: 187 A-PYGKSVDMWSVGCILGELSDGQ-PLFPGESEIDQLFTIQKVLGPLPSEQMKLFYS--- 241

Query: 266 DPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFY 325
           +PRF+ +  R       + +      +++   LD +  LL+ D   R    + + HP F 
Sbjct: 242 NPRFHGL--RFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQ 299

Query: 326 T 326
           T
Sbjct: 300 T 300


>1PHK-A nrPDB
          Length = 298

 Score =  259 bits (662), Expect = 1e-69,   Method: Composition-based stats.
 Identities = 71/320 (22%), Positives = 134/320 (41%), Gaps = 57/320 (17%)

Query: 34  GNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK------------KKKIKRE 81
           G  ++Y+    LGRG  S V   I+    ++  VKI+                ++   +E
Sbjct: 14  GFYENYEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQELREATLKE 73

Query: 82  IKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ---TLTDYDIRFYMY 138
           + IL  + G PNII L D  +   +    LVF+ +   +         TL++ + R  M 
Sbjct: 74  VDILRKVSGHPNIIQLKDTYE--TNTFFFLVFDLMKKGELFDYLTEKVTLSEKETRKIMR 131

Query: 139 EILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFK 198
            +L+ +   H + I+HRD+KP N+++D +   ++L D+G +    PG++      +  + 
Sbjct: 132 ALLEVICALHKLNIVHRDLKPENILLD-DDMNIKLTDFGFSCQLDPGEKLREVCGTPSYL 190

Query: 199 GPELLV-----DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTED 253
            PE++      ++  Y   +DMWS G ++ +++    PF+H      Q++ +  ++    
Sbjct: 191 APEIIECSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPFWH----RKQMLMLRMIMSGN- 245

Query: 254 LYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRL 313
                                +     W+ +         S    D + + L    Q R 
Sbjct: 246 --------------------YQFGSPEWDDY---------SDTVKDLVSRFLVVQPQKRY 276

Query: 314 TAREAMEHPYFYTVVKDQAR 333
           TA EA+ HP+F   V ++ R
Sbjct: 277 TAEEALAHPFFQQYVVEEVR 296


>4JG6-A nrPDB
          Length = 355

 Score =  259 bits (662), Expect = 2e-69,   Method: Composition-based stats.
 Identities = 80/349 (22%), Positives = 141/349 (40%), Gaps = 44/349 (12%)

Query: 26  YESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKIL 85
            + H       D Y++   +G G YS     I+   N +  VKI+   K+   + EI+IL
Sbjct: 24  QQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTE-EIEIL 82

Query: 86  ENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILK 142
                 PNIITL D+  D   +   +V E +   +        +  ++ +    ++ I K
Sbjct: 83  LRYGQHPNIITLKDVYDD--GKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITK 140

Query: 143 ALDYCHSMGIMHRDVKPHNVMIDHEHRK---LRLIDWGLAEFYH-PGQEYNVRVASRYFK 198
            ++Y H+ G++HRD+KP N++   E      +R+ D+G A+              +  F 
Sbjct: 141 TVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFV 200

Query: 199 GPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYI 258
            PE+L + Q YD + D+WSLG +L +M+    PF +G D+  +                 
Sbjct: 201 APEVL-ERQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPE----------------- 242

Query: 259 DKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREA 318
                       +IL R    ++   +     + VS  A D + K+L  D   RLTA   
Sbjct: 243 ------------EILARIGSGKFS--LSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALV 288

Query: 319 MEHPYF--YTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLG 365
           + HP+   +  +         +       +++       +  P   P+G
Sbjct: 289 LRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVG 337


>3ZDU-A nrPDB
          Length = 325

 Score =  259 bits (662), Expect = 2e-69,   Method: Composition-based stats.
 Identities = 76/298 (25%), Positives = 145/298 (48%), Gaps = 19/298 (6%)

Query: 35  NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKI----KREIKILENLRG 90
           + + Y+ + K+G G Y  V +  +    + V +KI     ++ +     REIK L+    
Sbjct: 1   SMEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQF-H 59

Query: 91  GPNIITLADIVKDPVSRTPALVFEHVNNT---DFKQLYQTLTDYDIRFYMYEILKALDYC 147
             N++ L ++ +    +   LVFE +++T   + +     L    +R Y+++IL+A+DY 
Sbjct: 60  HENLVNLIEVFRQK--KKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYL 117

Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFY-HPGQEYNVRVASRYFKGPELLVDY 206
           HS  I+HRD+KP N+++       +L D+G A     PG  Y+  VA+R+++ PEL++  
Sbjct: 118 HSNNIIHRDIKPENILVSQSGIT-KLCDFGFARTLAAPGDIYDDEVATRWYRAPELVLKD 176

Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 266
             Y   +D+W+LGCM+  M     P+     + D L +I  VL   +L  ++     +  
Sbjct: 177 TSYGKPVDIWALGCMIIEMATG-NPYLPSSSDLDLLHKI--VLKVGNLSPHLQNIFSKSP 233

Query: 267 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324
                +L +    +  R  + +   L++    D +   L+ D   R+++ + + H YF
Sbjct: 234 IFAGVVLPQVQHPKNARKKYPKLNGLLA----DIVHACLQIDPADRISSSDLLHHEYF 287


>5YKS-A nrPDB
          Length = 377

 Score =  259 bits (661), Expect = 2e-69,   Method: Composition-based stats.
 Identities = 70/303 (23%), Positives = 130/303 (42%), Gaps = 50/303 (16%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKI-----KREIKILENLRGGPN 93
           Y L + LGRG ++ V  A ++   EKV VK++   K   +      +E++ ++ L   PN
Sbjct: 37  YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMK-LVQHPN 95

Query: 94  IITLADIVKDPVSRTPALVFEHVNNTDFKQLY----QTLTDYDIRFYMYEILKALDYCHS 149
           I+ L +++         L+ E  +  D         + L +   + Y  +I+ A+ YCH 
Sbjct: 96  IVRLYEVIDTQT--KLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHK 153

Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMY 209
           + ++HRD+KP NV+   +   ++L D+G +  + PG++      S  +  PE+L+  +  
Sbjct: 154 LHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYD 213

Query: 210 DYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRF 269
             ++D+WSLG +L  ++  + PF   +D+ + L  I     T   +              
Sbjct: 214 APAVDIWSLGVILFMLVCGQPPFQEANDS-ETLTMIMDCKYTVPSH-------------- 258

Query: 270 NDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 329
                                  VS E  D + ++L+ D + R +  E   HP+   V  
Sbjct: 259 -----------------------VSKECKDLITRMLQRDPKRRASLEEIENHPWLQGVDP 295

Query: 330 DQA 332
             A
Sbjct: 296 SPA 298


>3N9X-A nrPDB
          Length = 432

 Score =  259 bits (661), Expect = 2e-69,   Method: Composition-based stats.
 Identities = 86/364 (23%), Positives = 160/364 (43%), Gaps = 70/364 (19%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPV-----KKKKIKREIKILENLRG 90
            D+Y +   +GRG Y  V+ A +    + V +K +  +       K+I REI IL  L+ 
Sbjct: 25  PDNYIIKHLIGRGSYGYVYLAYDKNTEKNVAIKKVNRMFEDLIDCKRILREITILNRLKS 84

Query: 91  GPNIITLAD-IVKDPV--SRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKAL 144
              II L D I+ D +       +V E + ++D K+L++T   LT+  I+  +Y +L   
Sbjct: 85  D-YIIRLYDLIIPDDLLKFDELYIVLE-IADSDLKKLFKTPIFLTEEHIKTILYNLLLGE 142

Query: 145 DYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ------------------ 186
           ++ H  GI+HRD+KP N +++ +   +++ D+GLA   +  +                  
Sbjct: 143 NFIHESGIIHRDLKPANCLLNQDC-SVKVCDFGLARTINSEKDTNIVNDLEENEEPGPHN 201

Query: 187 -----EYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMI----------FRKEP 231
                +    V +R+++ PEL++  + Y  S+D+WS GC+ A ++            + P
Sbjct: 202 KNLKKQLTSHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAELLNMLQSHINDPTNRFP 261

Query: 232 FFHG-----------------HDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILG 274
            F G                   N DQL  I  ++GT    D  +    E+         
Sbjct: 262 LFPGSSCFPLSPDRNSKKVHEKSNRDQLNIIFNIIGTPTEDDLKNINKPEVIKYIKLFPH 321

Query: 275 RHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARM 334
           R      +++        +S + ++ L+ +L+++   R+T  +A++HPY   V K +   
Sbjct: 322 RKPINLKQKYPS------ISDDGINLLESMLKFNPNKRITIDQALDHPYLKDVRKKKLEN 375

Query: 335 GSSS 338
            S+ 
Sbjct: 376 FSTK 379


>3MN3-A nrPDB
          Length = 271

 Score =  258 bits (660), Expect = 2e-69,   Method: Composition-based stats.
 Identities = 75/296 (25%), Positives = 131/296 (44%), Gaps = 50/296 (16%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL------KPVKKKKIKREIKILENLRGG 91
           +YQ+V+ LG G + +V  A + T  +KV +KI+      K   + +I+REI  L  LR  
Sbjct: 5   NYQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRH- 63

Query: 92  PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ--TLTDYDIRFYMYEILKALDYCHS 149
           P+II L D++K        +V E+  N  F  + Q   +++ + R +  +I+ A++YCH 
Sbjct: 64  PHIIKLYDVIKSKDE--IIMVIEYAGNELFDYIVQRDKMSEQEARRFFQQIISAVEYCHR 121

Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMY 209
             I+HRD+KP N+++D EH  +++ D+GL+     G        S  +  PE++      
Sbjct: 122 HKIVHRDLKPENLLLD-EHLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKLYA 180

Query: 210 DYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRF 269
              +D+WS G +L  M+ R+ PF                     L+  I      L    
Sbjct: 181 GPEVDVWSCGVILYVMLCRRLPFDDES--------------IPVLFKNISNGVYTLP--- 223

Query: 270 NDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFY 325
                                  +SP A   + ++L  +  +R++  E M+  +F 
Sbjct: 224 ---------------------KFLSPGAAGLIKRMLIVNPLNRISIHEIMQDDWFK 258


>3NIE-A nrPDB
          Length = 429

 Score =  258 bits (660), Expect = 3e-69,   Method: Composition-based stats.
 Identities = 91/382 (23%), Positives = 166/382 (43%), Gaps = 72/382 (18%)

Query: 21  REYWDYESHVVE-WGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPV-----K 74
           RE   ++  +++     D+Y++   +GRG Y  V+ A +   N+ V +K +  +      
Sbjct: 11  RENLYFQGAIIKNVKVPDNYEIKHLIGRGSYGYVYLAYDKNANKNVAIKKVNRMFEDLID 70

Query: 75  KKKIKREIKILENLRGGPNIITLADIV--KDPVSRTPALVFEHVNNTDFKQLYQT---LT 129
            K+I REI IL  L+    II L D++  +D +      +   + ++D K+L++T   LT
Sbjct: 71  CKRILREITILNRLKSD-YIIRLHDLIIPEDLLKFDELYIVLEIADSDLKKLFKTPIFLT 129

Query: 130 DYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ--- 186
           +  ++  +Y +L    + H  GI+HRD+KP N +++ +   +++ D+GLA   +  +   
Sbjct: 130 EQHVKTILYNLLLGEKFIHESGIIHRDLKPANCLLNQDC-SVKICDFGLARTINSDKDIH 188

Query: 187 -----------------------EYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLA 223
                                  +    V +R+++ PEL++  + Y  S+D+WS GC+ A
Sbjct: 189 IVNDLEEKEENEEPGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDIWSTGCIFA 248

Query: 224 SMI----------FRKEPFFHG-----------------HDNYDQLVRIAKVLGTEDLYD 256
            ++            + P F G                   N DQL  I  V+GT    D
Sbjct: 249 ELLNMMKSHINNPTNRFPLFPGSSCFPLSPDHNSKKVHEKSNRDQLNIIFNVIGTPPEED 308

Query: 257 YIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAR 316
                  E+         R      +    S+    +S E +D L+ +LR++ Q R+T  
Sbjct: 309 LKCITKQEVIKYIKLFPTR------DGIDLSKKYSSISKEGIDLLESMLRFNAQKRITID 362

Query: 317 EAMEHPYFYTVVKDQARMGSSS 338
           +A+ HPY   V K+     S+ 
Sbjct: 363 KALSHPYLKDVRKENLENFSTE 384


>3I6U-A nrPDB
          Length = 419

 Score =  257 bits (657), Expect = 6e-69,   Method: Composition-based stats.
 Identities = 75/318 (23%), Positives = 124/318 (38%), Gaps = 55/318 (17%)

Query: 27  ESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK---------- 76
           +  V     +D+Y + + LG G   EV  A      +KV ++I+   K            
Sbjct: 125 DQSVYPKALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSAREADPA 184

Query: 77  -KIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYD 132
             ++ EI+IL+ L   P II + +      +    +V E +   +        + L +  
Sbjct: 185 LNVETEIEILKKL-NHPCIIKIKNFFD---AEDYYIVLELMEGGELFDKVVGNKRLKEAT 240

Query: 133 IRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDH--EHRKLRLIDWGLAEFYHPGQEYNV 190
            + Y Y++L A+ Y H  GI+HRD+KP NV++    E   +++ D+G ++          
Sbjct: 241 CKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRT 300

Query: 191 RVASRYFKGPELLVDYQ--MYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKV 248
              +  +  PE+LV      Y+ ++D WSLG +L   +    PF                
Sbjct: 301 LCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQV--------- 351

Query: 249 LGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYD 308
                L D I        P                    E    VS +ALD + KLL  D
Sbjct: 352 ----SLKDQITSGKYNFIP--------------------EVWAEVSEKALDLVKKLLVVD 387

Query: 309 HQSRLTAREAMEHPYFYT 326
            ++R T  EA+ HP+   
Sbjct: 388 PKARFTTEEALRHPWLQD 405


>3UC3-A nrPDB
          Length = 361

 Score =  257 bits (657), Expect = 6e-69,   Method: Composition-based stats.
 Identities = 73/338 (21%), Positives = 135/338 (39%), Gaps = 45/338 (13%)

Query: 35  NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK--KKKIKREIKILENLRGGP 92
           + D Y  V+ +G G +       +    E V VK ++      + ++REI    +LR  P
Sbjct: 18  DSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGAAIDENVQREIINHRSLRH-P 76

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCHS 149
           NI+   +++  P     A++ E+ +  +  +        ++ + RF+  ++L  + YCHS
Sbjct: 77  NIVRFKEVILTPT--HLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHS 134

Query: 150 MGIMHRDVKPHNVMID-HEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQM 208
           M I HRD+K  N ++D     +L++ D+G ++      +    V +  +  PE+L+  + 
Sbjct: 135 MQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEY 194

Query: 209 YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPR 268
                D+WS G  L  M+    PF    +  D    I ++L          KY+I  D R
Sbjct: 195 DGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSV--------KYSIPDDIR 246

Query: 269 FNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVV 328
                                   +SPE    + ++   D  +R++  E   H +F   +
Sbjct: 247 ------------------------ISPECCHLISRIFVADPATRISIPEIKTHSWFLKNL 282

Query: 329 KDQARMGSSSMPGGSTP----VSSANMMSGISSVPTPS 362
                  S++      P     S   +M  IS    P+
Sbjct: 283 PADLMNESNTGSQFQEPEQPMQSLDTIMQIISEATIPA 320


>2JAM-A nrPDB
          Length = 304

 Score =  257 bits (656), Expect = 6e-69,   Method: Composition-based stats.
 Identities = 67/297 (22%), Positives = 124/297 (41%), Gaps = 47/297 (15%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPV---KKKKIKREIKILENLRGGP 92
           +  +  +  LG G +SEVF        +   +K +K     +   ++ EI +L+ ++   
Sbjct: 8   RKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDSSLENEIAVLKKIKH-E 66

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCHS 149
           NI+TL DI +        LV + V+  +           T+ D    + ++L A+ Y H 
Sbjct: 67  NIVTLEDIYESTTHY--YLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHE 124

Query: 150 MGIMHRDVKPHNVMI--DHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQ 207
            GI+HRD+KP N++     E+ K+ + D+GL++    G   +    +  +  PE+L   +
Sbjct: 125 NGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNG-IMSTACGTPGYVAPEVLAQ-K 182

Query: 208 MYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDP 267
            Y  ++D WS+G +   ++    PF+   ++               L++ I +   E + 
Sbjct: 183 PYSKAVDCWSIGVITYILLCGYPPFYEETES--------------KLFEKIKEGYYEFES 228

Query: 268 RFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324
            F                       +S  A DF+  LL  D   R T  +A+ HP+ 
Sbjct: 229 PF--------------------WDDISESAKDFICHLLEKDPNERYTCEKALSHPWI 265


>3UTO-A nrPDB
          Length = 573

 Score =  256 bits (655), Expect = 9e-69,   Method: Composition-based stats.
 Identities = 75/361 (20%), Positives = 141/361 (39%), Gaps = 61/361 (16%)

Query: 21  REYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL---KPVKKKK 77
           ++Y+     +      D Y +  +LG G +  V              K +       K+ 
Sbjct: 141 KQYYPQPVEIKHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKET 200

Query: 78  IKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQ----LYQTLTDYDI 133
           +++EI+ +  LR  P ++ L D  +D       +++E ++  +  +     +  +++ + 
Sbjct: 201 VRKEIQTMSVLRH-PTLVNLHDAFED--DNEMVMIYEFMSGGELFEKVADEHNKMSEDEA 257

Query: 134 RFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHE-HRKLRLIDWGLAEFYHPGQEYNVRV 192
             YM ++ K L + H    +H D+KP N+M   +   +L+LID+GL     P Q   V  
Sbjct: 258 VEYMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTT 317

Query: 193 ASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTE 252
            +  F  PE+  + +   Y  DMWS+G +   ++    PF  G ++ + L  +       
Sbjct: 318 GTAEFAAPEV-AEGKPVGYYTDMWSVGVLSYILLSGLSPF-GGENDDETLRNV------- 368

Query: 253 DLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSR 312
                                     K  +  +       +S +  DF+ KLL  D  +R
Sbjct: 369 --------------------------KSCDWNMDDSAFSGISEDGKDFIRKLLLADPNTR 402

Query: 313 LTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPT-----PSPLGPL 367
           +T  +A+EHP+              + PG  + + S+       S+ T     P PL PL
Sbjct: 403 MTIHQALEHPWL----------TPGNAPGRDSQIPSSRYTKIRDSIKTKYDAWPEPLPPL 452

Query: 368 A 368
            
Sbjct: 453 G 453


>3TAC-A nrPDB
          Length = 361

 Score =  256 bits (655), Expect = 1e-68,   Method: Composition-based stats.
 Identities = 76/309 (24%), Positives = 129/309 (41%), Gaps = 57/309 (18%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK--------KKKIKREIKILEN 87
           +D Y+L   +G+G +S V   IN    ++  VKI+   K         + +KRE  I   
Sbjct: 25  EDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHM 84

Query: 88  LRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT-------LTDYDIRFYMYEI 140
           L+  P+I+ L +           +VFE ++  D               ++     YM +I
Sbjct: 85  LKH-PHIVELLETYSS--DGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQI 141

Query: 141 LKALDYCHSMGIMHRDVKPHNVMIDHEHRK--LRLIDWGLA-EFYHPGQEYNVRVASRYF 197
           L+AL YCH   I+HRDVKPH V++  +     ++L  +G+A +    G     RV + +F
Sbjct: 142 LEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHF 201

Query: 198 KGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDY 257
             PE++   + Y   +D+W  G +L  ++    PF+                  E L++ 
Sbjct: 202 MAPEVV-KREPYGKPVDVWGCGVILFILLSGCLPFYGTK---------------ERLFEG 245

Query: 258 IDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTARE 317
           I K   +++PR                        +S  A D + ++L  D   R+T  E
Sbjct: 246 IIKGKYKMNPR--------------------QWSHISESAKDLVRRMLMLDPAERITVYE 285

Query: 318 AMEHPYFYT 326
           A+ HP+   
Sbjct: 286 ALNHPWLKE 294


>2Y7J-A nrPDB
          Length = 365

 Score =  256 bits (655), Expect = 1e-68,   Method: Composition-based stats.
 Identities = 71/308 (23%), Positives = 136/308 (44%), Gaps = 56/308 (18%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK-----------KKKIKREIKIL 85
             Y     +GRG  S V   ++     +  VKI++              ++  +RE  IL
Sbjct: 94  QKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHIL 153

Query: 86  ENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ---TLTDYDIRFYMYEILK 142
             + G P+IITL D  +   S    LVF+ +   +          L++ + R  M  +L+
Sbjct: 154 RQVAGHPHIITLIDSYES--SSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLE 211

Query: 143 ALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPEL 202
           A+ + H+  I+HRD+KP N+++D ++ ++RL D+G +    PG++      +  +  PE+
Sbjct: 212 AVSFLHANNIVHRDLKPENILLD-DNMQIRLSDFGFSCHLEPGEKLRELCGTPGYLAPEI 270

Query: 203 LV-----DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDY 257
           L       +  Y   +D+W+ G +L +++    PF+H      Q++ +  ++        
Sbjct: 271 LKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRR----QILMLRMIM-------- 318

Query: 258 IDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTARE 317
                        +   + S   W+           S    D + +LL+ D ++RLTA +
Sbjct: 319 -------------EGQYQFSSPEWDD---------RSSTVKDLISRLLQVDPEARLTAEQ 356

Query: 318 AMEHPYFY 325
           A++HP+F 
Sbjct: 357 ALQHPFFE 364


>2QNJ-A nrPDB
          Length = 328

 Score =  256 bits (655), Expect = 1e-68,   Method: Composition-based stats.
 Identities = 63/303 (20%), Positives = 135/303 (44%), Gaps = 50/303 (16%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL-----KPVKKKKIKREIKILENLRGGP 92
           +Y+L++ +G+G +++V  A +I    +V +KI+      P   +K+ RE++I++ L   P
Sbjct: 13  NYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKIL-NHP 71

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNT---DFKQLYQTLTDYDIRFYMYEILKALDYCHS 149
           NI+ L ++++    +T  L+ E+ +     D+   +  + + + R    +I+ A+ YCH 
Sbjct: 72  NIVKLFEVIE--TEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQ 129

Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMY 209
             I+HRD+K  N+++D +   +++ D+G +  +  G + +    S  +  PEL    +  
Sbjct: 130 KRIVHRDLKAENLLLDAD-MNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYD 188

Query: 210 DYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRF 269
              +D+WSLG +L +++    PF  G +  +   R+ +            KY I      
Sbjct: 189 GPEVDVWSLGVILYTLVSGSLPF-DGQNLKELRERVLR-----------GKYRIPF---- 232

Query: 270 NDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 329
                                  +S +  + L + L  +   R T  + M+  +     +
Sbjct: 233 ----------------------YMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHE 270

Query: 330 DQA 332
           +  
Sbjct: 271 EDE 273


>5KCV-A nrPDB
          Length = 460

 Score =  256 bits (654), Expect = 1e-68,   Method: Composition-based stats.
 Identities = 77/378 (20%), Positives = 144/378 (38%), Gaps = 70/378 (18%)

Query: 5   VPSRARVYTDVNTHRPREYWDYESHVVEWGN------QDDYQLVRKLGRGKYSEVFEAIN 58
           +  +A    D  +  P +    E   V           ++++ ++ LG+G + +V     
Sbjct: 124 LKKQAAAEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKE 183

Query: 59  ITNNEKVVVKILKPV------KKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALV 112
                   +KILK        +      E ++L+N R  P +  L    +         V
Sbjct: 184 KATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH-PFLTALKYSFQ--THDRLCFV 240

Query: 113 FEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCHS-MGIMHRDVKPHNVMIDHEH 168
            E+ N  +        +  ++   RFY  EI+ ALDY HS   +++RD+K  N+M+D + 
Sbjct: 241 MEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDG 300

Query: 169 RKLRLIDWGLAEF-YHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIF 227
             +++ D+GL +     G        +  +  PE+L D   Y  ++D W LG ++  M+ 
Sbjct: 301 H-IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDND-YGRAVDWWGLGVVMYEMMC 358

Query: 228 RKEPFF-HGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVH 286
            + PF+   H+   +L+ + ++                   RF   LG            
Sbjct: 359 GRLPFYNQDHEKLFELILMEEI-------------------RFPRTLG------------ 387

Query: 287 SENQHLVSPEALDFLDKLLRYDHQSRLT-----AREAMEHPYFYTVVKD---QARMGSSS 338
                   PEA   L  LL+ D + RL      A+E M+H +F  +V     + ++    
Sbjct: 388 --------PEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPF 439

Query: 339 MPGGSTPVSSANMMSGIS 356
            P  ++   +       +
Sbjct: 440 KPQVTSETDTRYFDEEFT 457


>3H4J-B nrPDB
          Length = 336

 Score =  256 bits (654), Expect = 1e-68,   Method: Composition-based stats.
 Identities = 67/303 (22%), Positives = 127/303 (41%), Gaps = 50/303 (16%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK------KIKREIKILENLRGGP 92
           Y +   LG G + +V  A +    +KV +K +     K      +++REI  L+ LR  P
Sbjct: 11  YIIRETLGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREISYLKLLRH-P 69

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT--LTDYDIRFYMYEILKALDYCHSM 150
           +II L D++  P      +V E+     F  + +   +T+ + R +  +I+ A++YCH  
Sbjct: 70  HIIKLYDVITTPTD--IVMVIEYAGGELFDYIVEKKRMTEDEGRRFFQQIICAIEYCHRH 127

Query: 151 GIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYD 210
            I+HRD+KP N+++D ++  +++ D+GL+     G        S  +  PE++       
Sbjct: 128 KIVHRDLKPENLLLD-DNLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVINGKLYAG 186

Query: 211 YSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFN 270
             +D+WS G +L  M+  + PF                    +L+  ++     +     
Sbjct: 187 PEVDVWSCGIVLYVMLVGRLPFDDE--------------FIPNLFKKVNSCVYVMP---- 228

Query: 271 DILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKD 330
                                 +SP A   + +++  D   R+T +E    P+F   + D
Sbjct: 229 --------------------DFLSPGAQSLIRRMIVADPMQRITIQEIRRDPWFNVNLPD 268

Query: 331 QAR 333
             R
Sbjct: 269 YLR 271


>3ZUT-A nrPDB
          Length = 362

 Score =  255 bits (652), Expect = 2e-68,   Method: Composition-based stats.
 Identities = 63/342 (18%), Positives = 132/342 (38%), Gaps = 41/342 (11%)

Query: 35  NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK--KKIKREIKILENLRGGP 92
           + D Y+LV+ +G G +       +  +NE V VK ++  +K  + +KREI    +LR  P
Sbjct: 17  DSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRH-P 75

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCHS 149
           NI+   +++  P     A+V E+ +  +  +        ++ + RF+  +++  + YCH+
Sbjct: 76  NIVRFKEVILTPT--HLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHA 133

Query: 150 MGIMHRDVKPHNVMID-HEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQM 208
           M + HRD+K  N ++D     +L++  +G ++      +    V +  +  PE+L+  + 
Sbjct: 134 MQVCHRDLKLENTLLDGSPAPRLKICAFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEY 193

Query: 209 YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPR 268
                D+WS G  L  M+    PF    +  +    I ++L  +                
Sbjct: 194 DGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAI------------- 240

Query: 269 FNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVV 328
                               +   +SPE    + ++   D   R++  E   H +F   +
Sbjct: 241 -------------------PDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNL 281

Query: 329 KDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLGPLAGS 370
                  ++              +  I  +   + + P    
Sbjct: 282 PADLMNDNTMTTQFDESDQPGQSIEEIMQIIAEATVPPAGTQ 323


>1KOA-A nrPDB
          Length = 491

 Score =  254 bits (650), Expect = 3e-68,   Method: Composition-based stats.
 Identities = 75/361 (20%), Positives = 141/361 (39%), Gaps = 61/361 (16%)

Query: 21  REYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL---KPVKKKK 77
           ++Y+     +      D Y +  +LG G +  V              K +       K+ 
Sbjct: 35  KQYYPQPVEIKHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKET 94

Query: 78  IKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQ----LYQTLTDYDI 133
           +++EI+ +  LR  P ++ L D  +D       +++E ++  +  +     +  +++ + 
Sbjct: 95  VRKEIQTMSVLRH-PTLVNLHDAFED--DNEMVMIYEFMSGGELFEKVADEHNKMSEDEA 151

Query: 134 RFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHE-HRKLRLIDWGLAEFYHPGQEYNVRV 192
             YM ++ K L + H    +H D+KP N+M   +   +L+LID+GL     P Q   V  
Sbjct: 152 VEYMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTT 211

Query: 193 ASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTE 252
            +  F  PE+  + +   Y  DMWS+G +   ++    PF  G ++ + L  +       
Sbjct: 212 GTAEFAAPEV-AEGKPVGYYTDMWSVGVLSYILLSGLSPF-GGENDDETLRNV------- 262

Query: 253 DLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSR 312
                                     K  +  +       +S +  DF+ KLL  D  +R
Sbjct: 263 --------------------------KSCDWNMDDSAFSGISEDGKDFIRKLLLADPNTR 296

Query: 313 LTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPT-----PSPLGPL 367
           +T  +A+EHP+              + PG  + + S+       S+ T     P PL PL
Sbjct: 297 MTIHQALEHPWL----------TPGNAPGRDSQIPSSRYTKIRDSIKTKYDAWPEPLPPL 346

Query: 368 A 368
            
Sbjct: 347 G 347


>2JDO-A nrPDB
          Length = 342

 Score =  254 bits (650), Expect = 4e-68,   Method: Composition-based stats.
 Identities = 71/341 (20%), Positives = 133/341 (39%), Gaps = 63/341 (18%)

Query: 35  NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPV------KKKKIKREIKILENL 88
             +D+  ++ LG+G + +V             +KIL+        +      E ++L+N 
Sbjct: 8   TMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNT 67

Query: 89  RGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALD 145
           R  P +  L    +         V E+ N  +        +  T+   RFY  EI+ AL+
Sbjct: 68  RH-PFLTALKYAFQ--THDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALE 124

Query: 146 YCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF-YHPGQEYNVRVASRYFKGPELLV 204
           Y HS  +++RD+K  N+M+D +   +++ D+GL +     G        +  +  PE+L 
Sbjct: 125 YLHSRDVVYRDIKLENLMLDKDGH-IKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLE 183

Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPFF-HGHDNYDQLVRIAKVLGTEDLYDYIDKYNI 263
           D   Y  ++D W LG ++  M+  + PF+   H+   +L+ + ++               
Sbjct: 184 DND-YGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEI--------------- 227

Query: 264 ELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT-----AREA 318
                                        +SPEA   L  LL+ D + RL      A+E 
Sbjct: 228 ------------------------RFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEV 263

Query: 319 MEHPYFYTVVKD---QARMGSSSMPGGSTPVSSANMMSGIS 356
           MEH +F ++      Q ++     P  ++ V +       +
Sbjct: 264 MEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFT 304


>5KZ7-A nrPDB
          Length = 346

 Score =  254 bits (648), Expect = 6e-68,   Method: Composition-based stats.
 Identities = 67/311 (21%), Positives = 138/311 (44%), Gaps = 51/311 (16%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK-----KKIKREIKILENLRGGP 92
           +Y+L++ +G+G +++V  A +I   ++V VKI+   +      +K+ RE++I++ L   P
Sbjct: 34  NYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVL-NHP 92

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNT---DFKQLYQTLTDYDIRFYMYEILKALDYCHS 149
           NI+ L ++++    +T  LV E+ +     D+   +  + + + R    +I+ A+ YCH 
Sbjct: 93  NIVKLFEVIE--TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQ 150

Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMY 209
             I+HRD+K  N+++D +   +++ D+G +  +  G + +    S  +  PEL    +  
Sbjct: 151 KFIVHRDLKAENLLLDAD-MNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYD 209

Query: 210 DYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRF 269
              +D+WSLG +L +++    PF  G +  +   R+ +            KY I      
Sbjct: 210 GPEVDVWSLGVILYTLVSGSLPF-DGQNLKELRERVLR-----------GKYRIPF---- 253

Query: 270 NDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 329
                                  +S +  + L K L  +   R T  + M+  +   V  
Sbjct: 254 ----------------------YMSTDCENLLKKFLILNPSKRGTLEQIMKDRWM-NVGH 290

Query: 330 DQARMGSSSMP 340
           +   +     P
Sbjct: 291 EDDELKPYVEP 301


>2HW6-A nrPDB
          Length = 307

 Score =  254 bits (648), Expect = 7e-68,   Method: Composition-based stats.
 Identities = 75/317 (23%), Positives = 131/317 (41%), Gaps = 42/317 (13%)

Query: 36  QDDYQLV-RKLGRGKYSEVFEAINITNNEKVVVKILKPV---KKKKIKREIKILENLRGG 91
           +D Y+L    LG G Y++V  A+++ N ++  VKI++      + ++ RE++ L   +G 
Sbjct: 11  EDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGN 70

Query: 92  PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYCH 148
            NI+ L +  +D       LVFE +         Q      + +    + ++  ALD+ H
Sbjct: 71  KNILELIEFFEDDTRF--YLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLH 128

Query: 149 SMGIMHRDVKPHNVMIDHEHRK--LRLIDWGLAEFYH--------PGQEYNVRVASRYFK 198
           + GI HRD+KP N++ +   +   +++ D+ L                E      S  + 
Sbjct: 129 TKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYM 188

Query: 199 GPELLV----DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDL 254
            PE++         YD   D+WSLG +L  M+    PF  GH   D            D 
Sbjct: 189 APEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFV-GHCGAD---------CGWDR 238

Query: 255 YDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT 314
            +       +L     +       K W           +S EA D + KLL  D + RL+
Sbjct: 239 GEVCRVCQNKLFESIQEGKYEFPDKDWAH---------ISSEAKDLISKLLVRDAKQRLS 289

Query: 315 AREAMEHPYFYTVVKDQ 331
           A + ++HP+      ++
Sbjct: 290 AAQVLQHPWVQGQAPEK 306


>4PDS-A nrPDB
          Length = 347

 Score =  253 bits (647), Expect = 7e-68,   Method: Composition-based stats.
 Identities = 78/315 (24%), Positives = 132/315 (41%), Gaps = 58/315 (18%)

Query: 32  EWGNQDDYQLV-RKLGRGKYSEVFEAINITNNEKVVVKILKPVKK----KKIKREIKILE 86
           + G   D+ ++   +G+G ++ V +AI  T  +   VKI+   K       + RE+++L+
Sbjct: 25  KTGIFKDFSIIDEVVGQGAFATVKKAIERTTGKTFSVKIISKRKVIGNMDGVTRELEVLQ 84

Query: 87  NLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQL---YQTLTDYDIRFYMYEILKA 143
            L   P I+ L    +D  S    +V E V+  D       +  + +   R    +IL A
Sbjct: 85  KL-NHPRIVRLKGFYEDTESY--YMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTA 141

Query: 144 LDYCHSMGIMHRDVKPHNVMIDHEHRK-LRLIDWGLAEFYHPGQEYNVRVASRYFKGPEL 202
           + Y HSMGI HRD+KP N++I+ +    +++  +GLA+    G        +  +  PE+
Sbjct: 142 IKYIHSMGISHRDLKPDNILIEQDDPVLVKITAFGLAKVQGNGSFMKTFCGTLAYVAPEV 201

Query: 203 LVD------------YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLG 250
           +                 Y   +DMWS+GC++  ++    PF       DQL        
Sbjct: 202 IRGKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPF--SGSTQDQL-------- 251

Query: 251 TEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQ 310
               Y  I + +    P                         +S EA DF+D LL+ D  
Sbjct: 252 ----YKQIGRGSYHEGP--------------------LKDFRISEEARDFIDSLLQVDPN 287

Query: 311 SRLTAREAMEHPYFY 325
           +R TA +A+ HP+  
Sbjct: 288 NRSTAAKALNHPWIK 302


>2W96-B nrPDB
          Length = 306

 Score =  253 bits (647), Expect = 8e-68,   Method: Composition-based stats.
 Identities = 82/303 (27%), Positives = 143/303 (47%), Gaps = 29/303 (9%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK-----IKREIKILENLR--G 90
            Y+ V ++G G Y  V++A +  +   V +K ++    ++       RE+ +L  L    
Sbjct: 5   RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGLPISTVREVALLRRLEAFE 64

Query: 91  GPNIITLADIV---KDPVSRTPALVFEHVNNTDFKQLYQT-----LTDYDIRFYMYEILK 142
            PN++ L D+    +        LVFEHV+  D +          L    I+  M + L+
Sbjct: 65  HPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQFLR 123

Query: 143 ALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPEL 202
            LD+ H+  I+HRD+KP N+++      ++L D+GLA  Y      +  V + +++ PE+
Sbjct: 124 GLDFLHANCIVHRDLKPENILVTS-GGTVKLADFGLARIYSYQMALDPVVVTLWYRAPEV 182

Query: 203 LVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYN 262
           L+    Y   +DMWS+GC+ A M FR++P F G+   DQL +I  ++G     D+     
Sbjct: 183 LLQ-STYATPVDMWSVGCIFAEM-FRRKPLFCGNSEADQLGKIFDLIGLPPEDDW----- 235

Query: 263 IELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHP 322
               PR   +       R  R V S    +    A   L+ +L ++   R++A  A++H 
Sbjct: 236 ----PRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLE-MLTFNPHKRISAFRALQHS 290

Query: 323 YFY 325
           Y +
Sbjct: 291 YLH 293


>4O2Z-A nrPDB
          Length = 377

 Score =  253 bits (646), Expect = 1e-67,   Method: Composition-based stats.
 Identities = 81/339 (23%), Positives = 157/339 (46%), Gaps = 27/339 (7%)

Query: 11  VYTDVNTHRPREYWDYESHVV---EWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVV 67
              +     P+   D++ + V    +     Y L++ LG G Y      ++    EKV +
Sbjct: 16  FQGNQELSVPKIVGDFKVYNVSGSPFEVPSKYTLLKILGMGAYGIACSCLDGDTGEKVSI 75

Query: 68  KILKPVKK-----KKIKREIKILENLRGGPNIITLADIV----KDPVSRTPALVFEHVNN 118
           K  + V +     K++ REI ++       N++ + +I+    ++  S     V   + +
Sbjct: 76  KKCRDVFRDVEDGKRVLREIDMMR-FFHHENLLNVVNILPPLKREYHSFEDVYVVTPLMD 134

Query: 119 TDFKQLYQT---LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLID 175
            D   + ++   L +  +++++Y+IL+ L Y HS  + HRD+KP N ++ +   +L++ID
Sbjct: 135 VDMNVVLRSRQVLEESHMQYFVYQILRGLKYLHSANVAHRDLKPAN-LVTNISCELKIID 193

Query: 176 WGLAEFYH-PGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFH 234
           +GL+     P  E    V +R+++ PELL++   Y  ++D+WS+GC+ A M + ++P F 
Sbjct: 194 FGLSRSVDVPYSELTDYVITRWYRPPELLLENTNYSTAVDIWSVGCIFAEM-YNRKPVFP 252

Query: 235 GHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVS 294
           G +  DQL  IA+ +G         +  +E      D      +       ++       
Sbjct: 253 GRNTMDQLRMIAQHIGKPPASIVEHREALEKLNELPDGSLNIPKLVPGLAGNT------- 305

Query: 295 PEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQAR 333
            E +DFL K+   D   R TA + + HPY   +  ++  
Sbjct: 306 -EGIDFLSKMWTLDPSKRPTAADMLAHPYLAHLHDEEDE 343


>4REW-A nrPDB
          Length = 540

 Score =  253 bits (646), Expect = 1e-67,   Method: Composition-based stats.
 Identities = 72/327 (22%), Positives = 128/327 (39%), Gaps = 54/327 (16%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK------KIKREIKILENLRGG 91
            Y L   LG G + +V    +     KV VKIL   K +      KI+REI+ L+ L   
Sbjct: 7   HYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLK-LFRH 65

Query: 92  PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCH 148
           P+II L  ++  P      +V E+V+  +          L + + R    +IL  +DYCH
Sbjct: 66  PHIIKLYQVISTPSD--IFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCH 123

Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQM 208
              ++HRD+KP NV++D  H   ++ D+GL+     G+       S  +  PE++     
Sbjct: 124 RHMVVHRDLKPENVLLDA-HMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLY 182

Query: 209 YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPR 268
               +D+WS G +L +++    PF   H                                
Sbjct: 183 AGPEVDIWSSGVILYALLCGTLPFDDDH-------------------------------- 210

Query: 269 FNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVV 328
               +    +K  +   ++     ++P  +  L  +L+ D   R + ++  EH +F    
Sbjct: 211 ----VPTLFKKICDGIFYT--PQYLNPSVISLLKHMLQVDPMKRASIKDIREHEWFKQ-- 262

Query: 329 KDQARMGSSSMPGGSTPVSSANMMSGI 355
            D  +      P  S+ +     +  +
Sbjct: 263 -DLPKYLFPEDPSYSSTMIDDEALKEV 288


>3MV5-A nrPDB
          Length = 342

 Score =  252 bits (644), Expect = 2e-67,   Method: Composition-based stats.
 Identities = 72/342 (21%), Positives = 135/342 (39%), Gaps = 64/342 (18%)

Query: 35  NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPV------KKKKIKREIKILENL 88
             ++++ ++ LG+G + +V             +KILK        +      E ++L+N 
Sbjct: 8   TMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNS 67

Query: 89  RGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALD 145
           R  P +  L    +         V E+ N  +        +  ++   RFY  EI+ ALD
Sbjct: 68  RH-PFLTALKYSFQ--THDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALD 124

Query: 146 YCHS-MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF-YHPGQEYNVRVASRYFKGPELL 203
           Y HS   +++RD+K  N+M+D +   +++ D+GL +     G        +  +  PE+L
Sbjct: 125 YLHSEKNVVYRDLKLENLMLDKDGH-IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVL 183

Query: 204 VDYQMYDYSLDMWSLGCMLASMIFRKEPFF-HGHDNYDQLVRIAKVLGTEDLYDYIDKYN 262
            D   Y  ++D W LG ++  M+  + PF+   H+   +L+ + ++              
Sbjct: 184 EDND-YGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEI-------------- 228

Query: 263 IELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT-----ARE 317
                RF   LG                    PEA   L  LL+ D + RL      A+E
Sbjct: 229 -----RFPRTLG--------------------PEAKSLLSGLLKKDPKQRLGGGSEDAKE 263

Query: 318 AMEHPYFYTVVKD---QARMGSSSMPGGSTPVSSANMMSGIS 356
            M+H +F  +V     + ++     P  ++   +       +
Sbjct: 264 IMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFT 305


>1KOB-A nrPDB
          Length = 387

 Score =  251 bits (641), Expect = 4e-67,   Method: Composition-based stats.
 Identities = 79/365 (21%), Positives = 143/365 (39%), Gaps = 57/365 (15%)

Query: 21  REYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK---PVKKKK 77
           ++Y      V +    D Y ++ +LG G +  V   +        V K +    P+ K  
Sbjct: 35  KKYVPQPVEVKQGSVYDYYDILEELGSGAFGVVHRCVEKATGRVFVAKFINTPYPLDKYT 94

Query: 78  IKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ----TLTDYDI 133
           +K EI I+  L   P +I L D  +D       L+ E ++  +           +++ ++
Sbjct: 95  VKNEISIMNQL-HHPKLINLHDAFEDKYE--MVLILEFLSGGELFDRIAAEDYKMSEAEV 151

Query: 134 RFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEH-RKLRLIDWGLAEFYHPGQEYNVRV 192
             YM +  + L + H   I+H D+KP N+M + +    +++ID+GLA   +P +   V  
Sbjct: 152 INYMRQACEGLKHMHEHSIVHLDIKPENIMCETKKASSVKIIDFGLATKLNPDEIVKVTT 211

Query: 193 ASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTE 252
           A+  F  PE +VD +   +  DMW++G +   ++    PF  G D+ + L  +       
Sbjct: 212 ATAEFAAPE-IVDREPVGFYTDMWAIGVLGYVLLSGLSPF-AGEDDLETLQNV------- 262

Query: 253 DLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSR 312
                                     KR +     +    VSPEA DF+  LL+ + + R
Sbjct: 263 --------------------------KRCDWEFDEDAFSSVSPEAKDFIKNLLQKEPRKR 296

Query: 313 LTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLGPLAGSPV 372
           LT  +A+EHP+                   ++ + S+        +       P     +
Sbjct: 297 LTVHDALEHPWLK-----------GDHSNLTSRIPSSRYNKIRQKIKEKYADWPAPQPAI 345

Query: 373 IAAAN 377
              AN
Sbjct: 346 GRIAN 350


>1FOT-A nrPDB
          Length = 318

 Score =  251 bits (640), Expect = 6e-67,   Method: Composition-based stats.
 Identities = 64/317 (20%), Positives = 132/317 (41%), Gaps = 57/317 (17%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKR-----EIKILENLRGG 91
            D+Q++R LG G +  V    +  N     +K+LK     ++K+     + +++ ++   
Sbjct: 6   QDFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTH 65

Query: 92  PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYCH 148
           P II +    +D  ++   ++ +++   +   L +      +   +FY  E+  AL+Y H
Sbjct: 66  PFIIRMWGTFQD--AQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYLH 123

Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQM 208
           S  I++RD+KP N+++D ++  +++ D+G A++            +  +  PE++   + 
Sbjct: 124 SKDIIYRDLKPENILLD-KNGHIKITDFGFAKYVPDVTY--TLCGTPDYIAPEVV-STKP 179

Query: 209 YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPR 268
           Y+ S+D WS G ++  M+    PF+  +              T   Y+ I    +   P 
Sbjct: 180 YNKSIDWWSFGILIYEMLAGYTPFYDSN--------------TMKTYEKILNAELRFPPF 225

Query: 269 FNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRL-----TAREAMEHPY 323
           FN+                        +  D L +L+  D   RL        +   HP+
Sbjct: 226 FNE------------------------DVKDLLSRLITRDLSQRLGNLQNGTEDVKNHPW 261

Query: 324 FYTVVKDQARMGSSSMP 340
           F  VV ++    +   P
Sbjct: 262 FKEVVWEKLLSRNIETP 278


>5JZN-A nrPDB
          Length = 280

 Score =  250 bits (638), Expect = 8e-67,   Method: Composition-based stats.
 Identities = 69/300 (23%), Positives = 125/300 (41%), Gaps = 48/300 (16%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK----KIKREIKILENLRGGP 92
           + Y++ R +G G ++ V E +  +   +  +KI+K  K +     I+ E+ IL  ++  P
Sbjct: 19  ERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHMIQNEVSILRRVKH-P 77

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCHS 149
           NI+ L + +  P      LV E V   D           T+ D    +Y +  A+ Y HS
Sbjct: 78  NIVLLIEEMDVPTE--LYLVMELVKGGDLFDAITSTNKYTERDASGMLYNLASAIKYLHS 135

Query: 150 MGIMHRDVKPHNVMI---DHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDY 206
           + I+HRD+KP N+++       + L+L D+GLA     G  Y V   +  +  PE++ + 
Sbjct: 136 LNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIV-DGPLYTV-CGTPTYVAPEIIAET 193

Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 266
             Y   +D+W+ G +   ++    PF    D+ + L            +D I    ++  
Sbjct: 194 -GYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVL------------FDQILMGQVDFP 240

Query: 267 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYT 326
             +                       VS  A + +  +L  D   R +A + +EHP+   
Sbjct: 241 SPY--------------------WDNVSDSAKELITMMLLVDVDQRFSAVQVLEHPWVND 280


>2HAK-A nrPDB
          Length = 328

 Score =  250 bits (638), Expect = 9e-67,   Method: Composition-based stats.
 Identities = 67/292 (22%), Positives = 137/292 (46%), Gaps = 26/292 (8%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL-----KPVKKKKIKREIKILENLRGGP 92
           +Y+L + +G+G +++V  A ++    +V VKI+      P   +K+ RE++I++ L   P
Sbjct: 16  NYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKIL-NHP 74

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNT---DFKQLYQTLTDYDIRFYMYEILKALDYCHS 149
           NI+ L ++++    +T  LV E+ +     D+   +  + + + R    +I+ A+ YCH 
Sbjct: 75  NIVKLFEVIE--TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQ 132

Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMY 209
             I+HRD+K  N+++D +   +++ D+G +  +  G + +    S  +  PEL    +  
Sbjct: 133 KYIVHRDLKAENLLLDGD-MNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYD 191

Query: 210 DYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLY-----DYIDKYNIE 264
              +D+WSLG +L +++    PF  G +  +   R+ +       Y     + + K  + 
Sbjct: 192 GPEVDVWSLGVILYTLVSGSLPF-DGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLV 250

Query: 265 LDPRFNDILGRHSRKRWERFVHSENQ-HLVSPEALDFLDKLLRYDHQSRLTA 315
           L+P     L +  + RW    H E +    +    DF       +   R+  
Sbjct: 251 LNPIKRGSLEQIMKDRWMNVGHEEEELKPYTEPDPDF-------NDTKRIDI 295


>4CFH-A nrPDB
          Length = 493

 Score =  250 bits (638), Expect = 1e-66,   Method: Composition-based stats.
 Identities = 73/327 (22%), Positives = 128/327 (39%), Gaps = 54/327 (16%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK------KIKREIKILENLRGG 91
            Y L   LG G + +V    +     KV VKIL   K +      KI+REI+ L+ L   
Sbjct: 34  HYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLK-LFRH 92

Query: 92  PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCH 148
           P+II L  ++  P      +V E+V+  +          L + + R    +IL  +DYCH
Sbjct: 93  PHIIKLYQVISTPSD--IFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCH 150

Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQM 208
              ++HRD+KP NV++D  H   ++ D+GL+     G+       S  +  PE++     
Sbjct: 151 RHMVVHRDLKPENVLLDA-HMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLY 209

Query: 209 YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPR 268
               +D+WS G +L +++    PF   H                                
Sbjct: 210 AGPEVDIWSSGVILYALLCGTLPFDDDH-------------------------------- 237

Query: 269 FNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVV 328
               +    +K  +   ++     ++P  +  L  +L+ D   R T ++  EH +F    
Sbjct: 238 ----VPTLFKKICDGIFYT--PQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQ-- 289

Query: 329 KDQARMGSSSMPGGSTPVSSANMMSGI 355
            D  +      P  S+ +     +  +
Sbjct: 290 -DLPKYLFPEDPSYSSTMIDDEALKEV 315


>4RED-A nrPDB
          Length = 351

 Score =  250 bits (638), Expect = 1e-66,   Method: Composition-based stats.
 Identities = 72/327 (22%), Positives = 127/327 (38%), Gaps = 54/327 (16%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK------KIKREIKILENLRGG 91
            Y L   LG G + +V    +      V VKIL   K +      KI+REI+ L+ L   
Sbjct: 15  HYILGDTLGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLDVVGKIRREIQNLK-LFRH 73

Query: 92  PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCH 148
           P+II L  ++  P      +V E+V+  +          L + + R    +IL  +DYCH
Sbjct: 74  PHIIKLYQVISTPSD--IFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCH 131

Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQM 208
              ++HRD+KP NV++D  H   ++ D+GL+     G+       S  +  PE++     
Sbjct: 132 RHMVVHRDLKPENVLLDA-HMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLY 190

Query: 209 YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPR 268
               +D+WS G +L +++    PF   H                                
Sbjct: 191 AGPEVDIWSSGVILYALLCGTLPFDDDH-------------------------------- 218

Query: 269 FNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVV 328
               +    +K  +   ++     ++P  +  L  +L+ D   R + ++  EH +F    
Sbjct: 219 ----VPTLFKKICDGIFYT--PQYLNPSVISLLKHMLQVDPMKRASIKDIREHEWFKQ-- 270

Query: 329 KDQARMGSSSMPGGSTPVSSANMMSGI 355
            D  +      P  ST +     +  +
Sbjct: 271 -DLPKYLFPEDPSYSTTMIDDEALKEV 296


>4CFF-A nrPDB
          Length = 571

 Score =  249 bits (636), Expect = 1e-66,   Method: Composition-based stats.
 Identities = 72/298 (24%), Positives = 118/298 (39%), Gaps = 51/298 (17%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK------KIKREIKILENLRGG 91
            Y L   LG G + +V    +     KV VKIL   K +      KIKREI+ L+ L   
Sbjct: 34  HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK-LFRH 92

Query: 92  PNIITLADIVKDPVSRTPALVFEHVNNTDFKQL---YQTLTDYDIRFYMYEILKALDYCH 148
           P+II L  ++  P      +V E+V+  +       +  + + + R    +IL A+DYCH
Sbjct: 93  PHIIKLYQVISTPTDF--FMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCH 150

Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQM 208
              ++HRD+KP NV++D  H   ++ D+GL+     G+       S  +  PE++     
Sbjct: 151 RHMVVHRDLKPENVLLDA-HMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLY 209

Query: 209 YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPR 268
               +D+WS G +L +++    PF   H                 L+  I      +   
Sbjct: 210 AGPEVDIWSCGVILYALLCGTLPFDDEH--------------VPTLFKKIRGGVFYIPEY 255

Query: 269 FNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYT 326
            N  +                           L  +L+ D   R T ++  EH +F  
Sbjct: 256 LNRSVAT------------------------LLMHMLQVDPLKRATIKDIREHEWFKQ 289


>5EZV-A nrPDB
          Length = 560

 Score =  249 bits (636), Expect = 1e-66,   Method: Composition-based stats.
 Identities = 72/298 (24%), Positives = 118/298 (39%), Gaps = 51/298 (17%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK------KIKREIKILENLRGG 91
            Y L   LG G + +V    +     KV VKIL   K +      KIKREI+ L+ L   
Sbjct: 29  HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK-LFRH 87

Query: 92  PNIITLADIVKDPVSRTPALVFEHVNNTDFKQL---YQTLTDYDIRFYMYEILKALDYCH 148
           P+II L  ++  P      +V E+V+  +       +  + + + R    +IL A+DYCH
Sbjct: 88  PHIIKLYQVISTPTDF--FMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCH 145

Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQM 208
              ++HRD+KP NV++D  H   ++ D+GL+     G+       S  +  PE++     
Sbjct: 146 RHMVVHRDLKPENVLLDA-HMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLY 204

Query: 209 YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPR 268
               +D+WS G +L +++    PF   H                 L+  I      +   
Sbjct: 205 AGPEVDIWSCGVILYALLCGTLPFDDEH--------------VPTLFKKIRGGVFYIPEY 250

Query: 269 FNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYT 326
            N  +                           L  +L+ D   R T ++  EH +F  
Sbjct: 251 LNRSVAT------------------------LLMHMLQVDPLKRATIKDIREHEWFKQ 284


>5F9E-A nrPDB
          Length = 353

 Score =  249 bits (636), Expect = 2e-66,   Method: Composition-based stats.
 Identities = 76/367 (20%), Positives = 137/367 (37%), Gaps = 64/367 (17%)

Query: 13  TDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP 72
            ++N  RP         +      +D++L + LG+G + +VF A     N+   +K LK 
Sbjct: 3   PELNKERPS--------LQIKLKIEDFELHKMLGKGSFGKVFLAEFKKTNQFFAIKALKK 54

Query: 73  V------KKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ 126
                    +    E ++L      P +  +    +         V E++N  D     Q
Sbjct: 55  DVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQ--TKENLFFVMEYLNGGDLMYHIQ 112

Query: 127 ---TLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH 183
                      FY  EI+  L + HS GI++RD+K  N+++D +   +++ D+G+ +   
Sbjct: 113 SCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGH-IKIADFGMCKENM 171

Query: 184 PGQ-EYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQL 242
            G  + N    +  +  PE+L+  Q Y++S+D WS G +L  M+  + PF HG D  +  
Sbjct: 172 LGDAKTNEFCGTPDYIAPEILLG-QKYNHSVDWWSFGVLLYEMLIGQSPF-HGQDEEELF 229

Query: 243 VRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLD 302
             I                +    PR+ +                        EA D L 
Sbjct: 230 HSIRM--------------DNPFYPRWLE-----------------------KEAKDLLV 252

Query: 303 KLLRYDHQSRLTAR-EAMEHPYFYTVVKDQA---RMGSSSMPGGSTPVSSANMMSGISSV 358
           KL   + + RL  R +  +HP F  +  ++     +     P   +P   +N      + 
Sbjct: 253 KLFVREPEKRLGVRGDIRQHPLFREINWEELERKEIDPPFRPKVKSPFDCSNFDKEFLNE 312

Query: 359 PTPSPLG 365
                  
Sbjct: 313 KPRLSFA 319


>6C9D-A nrPDB
          Length = 459

 Score =  249 bits (635), Expect = 2e-66,   Method: Composition-based stats.
 Identities = 67/292 (22%), Positives = 137/292 (46%), Gaps = 26/292 (8%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL-----KPVKKKKIKREIKILENLRGGP 92
           +Y+L + +G+G +++V  A ++    +V VKI+      P   +K+ RE++I++ L   P
Sbjct: 22  NYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKIL-NHP 80

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNT---DFKQLYQTLTDYDIRFYMYEILKALDYCHS 149
           NI+ L ++++    +T  LV E+ +     D+   +  + + + R    +I+ A+ YCH 
Sbjct: 81  NIVKLFEVIE--TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQ 138

Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMY 209
             I+HRD+K  N+++D +   +++ D+G +  +  G + +    S  +  PEL    +  
Sbjct: 139 KYIVHRDLKAENLLLDGD-MNIKIADFGFSNEFTVGNKLDEFCGSPPYAAPELFQGKKYD 197

Query: 210 DYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLY-----DYIDKYNIE 264
              +D+WSLG +L +++    PF  G +  +   R+ +       Y     + + K  + 
Sbjct: 198 GPEVDVWSLGVILYTLVSGSLPF-DGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLV 256

Query: 265 LDPRFNDILGRHSRKRWERFVHSENQ-HLVSPEALDFLDKLLRYDHQSRLTA 315
           L+P     L +  + RW    H E +    +    DF       +   R+  
Sbjct: 257 LNPIKRGSLEQIMKDRWMNVGHEEEELKPYTEPDPDF-------NDTKRIDI 301


>3D2K-A nrPDB
          Length = 272

 Score =  249 bits (635), Expect = 2e-66,   Method: Composition-based stats.
 Identities = 71/298 (23%), Positives = 132/298 (44%), Gaps = 53/298 (17%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK------IKREIKILENLRG 90
           +D+ + R LG+GK+  V+ A    +   + +K+L   + +K      ++RE++I  +LR 
Sbjct: 12  EDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVEHQLRREVEIQSHLRH 71

Query: 91  GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLT---DYDIRFYMYEILKALDYC 147
            PNI+ L     D       L+ E+       +  Q L+   +     Y+ E+  AL YC
Sbjct: 72  -PNILRLYGYFHDATR--VYLILEYAPLGTVYRELQKLSRFDEQRTATYITELANALSYC 128

Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQ 207
           HS  ++HRD+KP N+++   + +L++ D+G +  + P         +  +  PE++ + +
Sbjct: 129 HSKRVIHRDIKPENLLLGS-NGELKIADFGWS-VHAPSSRRTTLCGTLDYLPPEMI-EGR 185

Query: 208 MYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDP 267
           M+D  +D+WSLG +    +    PF   H   +   RI++V  T   +            
Sbjct: 186 MHDEKVDLWSLGVLCYEFLVGMPPF-EAHTYQETYRRISRVEFTFPDF------------ 232

Query: 268 RFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFY 325
                                    V+  A D + +LL+++   RLT  E +EHP+  
Sbjct: 233 -------------------------VTEGARDLISRLLKHNASQRLTLAEVLEHPWIK 265


>3IS5-A nrPDB
          Length = 285

 Score =  248 bits (634), Expect = 2e-66,   Method: Composition-based stats.
 Identities = 61/303 (20%), Positives = 130/303 (42%), Gaps = 53/303 (17%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK----KKIKREIKILENLRGGP 92
           D +   RKLG G + +V      ++  + V+K +   +     ++I+ EI++L++L   P
Sbjct: 22  DLFIFKRKLGSGAFGDVHLVEERSSGLERVIKTINKDRSQVPMEQIEAEIEVLKSL-DHP 80

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNTDFKQLY-------QTLTDYDIRFYMYEILKALD 145
           NII + ++ +D       +V E     +  +         + L++  +   M +++ AL 
Sbjct: 81  NIIKIFEVFEDY--HNMYIVMETCEGGELLERIVSAQARGKALSEGYVAELMKQMMNALA 138

Query: 146 YCHSMGIMHRDVKPHNVMI--DHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELL 203
           Y HS  ++H+D+KP N++      H  +++ID+GLAE +   +       +  +  PE+ 
Sbjct: 139 YFHSQHVVHKDLKPENILFQDTSPHSPIKIIDFGLAELFKSDEHSTNAAGTALYMAPEVF 198

Query: 204 VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNI 263
              +   +  D+WS G ++  ++    PF     + +++ +                Y +
Sbjct: 199 --KRDVTFKCDIWSAGVVMYFLLTGCLPF--TGTSLEEVQQ--------KATYKEPNYAV 246

Query: 264 ELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323
           E  P                         ++P+A+D L ++L  D + R +A + + H +
Sbjct: 247 ECRP-------------------------LTPQAVDLLKQMLTKDPERRPSAAQVLHHEW 281

Query: 324 FYT 326
           F  
Sbjct: 282 FKQ 284


>3UDB-A nrPDB
          Length = 317

 Score =  248 bits (634), Expect = 3e-66,   Method: Composition-based stats.
 Identities = 66/323 (20%), Positives = 129/323 (39%), Gaps = 49/323 (15%)

Query: 35  NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK--KKIKREIKILENLRGGP 92
           + D Y+LV+ +G G +       +   NE V VK ++  +K  + +KREI    +LR  P
Sbjct: 17  DSDRYELVKDIGAGNFGVARLMRDKQANELVAVKYIERGEKIDENVKREIINHRSLRH-P 75

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCHS 149
           NI+   +++  P     A+V E+ +  +  +        ++ + RF+  +++  + Y H+
Sbjct: 76  NIVRFKEVILTPT--HLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYAHA 133

Query: 150 MGIMHRDVKPHNVMID-HEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQM 208
           M + HRD+K  N ++D     +L++ D+G ++      +    V +  +  PE+L+  + 
Sbjct: 134 MQVAHRDLKLENTLLDGSPAPRLKIADFGYSKASVLHSQPKSAVGTPAYIAPEVLLKKEY 193

Query: 209 YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPR 268
                D+WS G  L  M+    PF    +  +    I ++L  +                
Sbjct: 194 DGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAI------------- 240

Query: 269 FNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF---- 324
                               +   +SPE    + ++   D   R++  E   H +F    
Sbjct: 241 -------------------PDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNL 281

Query: 325 -YTVVKDQARM---GSSSMPGGS 343
              ++ D         S  PG S
Sbjct: 282 PADLMNDNTMTTQFDESDQPGQS 304


>3KN6-A nrPDB
          Length = 325

 Score =  248 bits (634), Expect = 3e-66,   Method: Composition-based stats.
 Identities = 68/290 (23%), Positives = 129/290 (44%), Gaps = 36/290 (12%)

Query: 43  RKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVK 102
           + LG G +S   + ++  +N+   VKI+    +   ++EI  L+   G PNI+ L ++  
Sbjct: 17  KPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALKLCEGHPNIVKLHEVFH 76

Query: 103 DPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYCHSMGIMHRDVKP 159
           D +     LV E +N  +  +  +     ++ +  + M +++ A+ + H +G++HRD+KP
Sbjct: 77  DQL--HTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLKP 134

Query: 160 HNVMID--HEHRKLRLIDWGLAEFYHPGQE-YNVRVASRYFKGPELLVDYQMYDYSLDMW 216
            N++    +++ ++++ID+G A    P  +       + ++  PELL +   YD S D+W
Sbjct: 135 ENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELL-NQNGYDESCDLW 193

Query: 217 SLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRH 276
           SLG +L +M+  + PF   HD         + L      + + K                
Sbjct: 194 SLGVILYTMLSGQVPF-QSHD---------RSLTCTSAVEIMKKI--------------- 228

Query: 277 SRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYT 326
             K+ +     E    VS EA D +  LL  D   RL       + +   
Sbjct: 229 --KKGDFSFEGEAWKNVSQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQD 276


>3EB0-A nrPDB
          Length = 383

 Score =  247 bits (632), Expect = 4e-66,   Method: Composition-based stats.
 Identities = 92/369 (24%), Positives = 164/369 (44%), Gaps = 58/369 (15%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITL 97
            Y L + LG G +  V E  +I + ++  +K +    + K  RE+ I++ L    NII L
Sbjct: 8   KYSLGKTLGTGSFGIVCEVFDIESGKRFALKKVLQDPRYK-NRELDIMKVL-DHVNIIKL 65

Query: 98  ADIVKDPVS------------------------------------RTPALVFEHVNNT-- 119
            D                                           +   ++ E+V +T  
Sbjct: 66  VDYFYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNVIMEYVPDTLH 125

Query: 120 ----DFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLID 175
                F +  +++    I  Y+Y++ +A+ + HS+GI HRD+KP N++++ +   L+L D
Sbjct: 126 KVLKSFIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLLVNSKDNTLKLCD 185

Query: 176 WGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHG 235
           +G A+   P +     + SR+++ PEL++    Y  S+D+WS+GC+   +I  K P F G
Sbjct: 186 FGSAKKLIPSEPSVAYICSRFYRAPELMLGATEYTPSIDLWSIGCVFGELILGK-PLFSG 244

Query: 236 HDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSP 295
             + DQLVRI +++GT      I       + RF  +      K W + +      L   
Sbjct: 245 ETSIDQLVRIIQIMGTPTKEQMIRMNPHYTEVRFPTLKA----KDWRKILPEGTPSL--- 297

Query: 296 EALDFLDKLLRYDHQSRLTAREAMEHPYFYTVV---KDQARMGSSSMPGGST--PVSSAN 350
            A+D L+++LRY+   R+   EAM HP+F  +    + + +  S+   G +   P     
Sbjct: 298 -AIDLLEQILRYEPDLRINPYEAMAHPFFDHLRNSYESEVKNNSNFPHGVNQNIPQLFNF 356

Query: 351 MMSGISSVP 359
               +S +P
Sbjct: 357 SPYELSIIP 365


>4UZD-A nrPDB
          Length = 287

 Score =  246 bits (629), Expect = 9e-66,   Method: Composition-based stats.
 Identities = 70/297 (23%), Positives = 132/297 (44%), Gaps = 53/297 (17%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK------IKREIKILENLRG 90
           +D+++ R LG+GK+  V+ A    +   + +K+L   + +K      ++RE++I  +LR 
Sbjct: 8   EDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRH 67

Query: 91  GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLT---DYDIRFYMYEILKALDYC 147
            PNI+ L     D       L+ E+       +  Q L+   +     Y+ E+  AL YC
Sbjct: 68  -PNILRLYGYFHDATR--VYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYC 124

Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQ 207
           HS  ++HRD+KP N+++     +L++ D+G +  + P         +  +  PE++ + +
Sbjct: 125 HSKRVIHRDIKPENLLLGSAG-ELKIADFGWS-VHAPSSRRTTLCGTLDYLPPEMI-EGR 181

Query: 208 MYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDP 267
           M+D  +D+WSLG +    +  K PF   +   +   RI++V  T   +            
Sbjct: 182 MHDEKVDLWSLGVLCYEFLVGKPPF-EANTYQETYKRISRVEFTFPDF------------ 228

Query: 268 RFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324
                                    V+  A D + +LL+++   R   RE +EHP+ 
Sbjct: 229 -------------------------VTEGARDLISRLLKHNPSQRPMLREVLEHPWI 260


>2YZA-A nrPDB
          Length = 276

 Score =  246 bits (629), Expect = 9e-66,   Method: Composition-based stats.
 Identities = 72/298 (24%), Positives = 118/298 (39%), Gaps = 51/298 (17%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK------KIKREIKILENLRGG 91
            Y L   LG G + +V    +     KV VKIL   K +      KIKREI+ L+ L   
Sbjct: 12  HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK-LFRH 70

Query: 92  PNIITLADIVKDPVSRTPALVFEHVNNTDFKQL---YQTLTDYDIRFYMYEILKALDYCH 148
           P+II L  ++  P      +V E+V+  +       +  + + + R    +IL A+DYCH
Sbjct: 71  PHIIKLYQVISTPTDF--FMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCH 128

Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQM 208
              ++HRD+KP NV++D  H   ++ D+GL+     G+       S  +  PE++     
Sbjct: 129 RHMVVHRDLKPENVLLDA-HMNAKIADFGLSNMMSDGEFLRDSCGSPNYAAPEVISGRLY 187

Query: 209 YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPR 268
               +D+WS G +L +++    PF   H                 L+  I      +   
Sbjct: 188 AGPEVDIWSCGVILYALLCGTLPFDDEH--------------VPTLFKKIRGGVFYIPEY 233

Query: 269 FNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYT 326
            N  +                           L  +L+ D   R T ++  EH +F  
Sbjct: 234 LNRSVAT------------------------LLMHMLQVDPLKRATIKDIREHEWFKQ 267


>5D9K-A nrPDB
          Length = 330

 Score =  246 bits (628), Expect = 1e-65,   Method: Composition-based stats.
 Identities = 72/349 (20%), Positives = 137/349 (39%), Gaps = 63/349 (18%)

Query: 32  EWGNQDDYQLVRKLGRGKYSEVFEAINITNN---EKVVVKILKPV-----KKKKIKREIK 83
           E  +   ++L++ LG+G + +VF    I+ +   +   +K+LK        + + K E  
Sbjct: 25  EKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERD 84

Query: 84  ILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEI 140
           IL  +   P I+ L    +        L+ + +   D           T+ D++FY+ E+
Sbjct: 85  ILVEV-NHPFIVKLHYAFQ--TEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAEL 141

Query: 141 LKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF-YHPGQEYNVRVASRYFKG 199
             ALD+ HS+GI++RD+KP N+++D E   ++L D+GL++      ++      +  +  
Sbjct: 142 ALALDHLHSLGIIYRDLKPENILLDEEGH-IKLTDFGLSKESIDHEKKAYSFCGTVEYMA 200

Query: 200 PELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYID 259
           PE++ + + +  S D WS G ++  M+    PF  G D  + +  I K            
Sbjct: 201 PEVV-NRRGHTQSADWWSFGVLMFEMLTGTLPF-QGKDRKETMTMILK------------ 246

Query: 260 KYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTA---- 315
                                            +SPEA   L  L + +  +RL A    
Sbjct: 247 -------------------------AKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDG 281

Query: 316 -REAMEHPYFYTVVKDQA---RMGSSSMPGGSTPVSSANMMSGISSVPT 360
             E   H +F T+  ++     +     P    P  +       ++   
Sbjct: 282 VEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTP 330


>5ZTN-A nrPDB
          Length = 429

 Score =  245 bits (626), Expect = 2e-65,   Method: Composition-based stats.
 Identities = 77/322 (23%), Positives = 152/322 (47%), Gaps = 40/322 (12%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK--KKIKREIKILENLR-----G 90
            Y++++ +G+G + +V +A +   ++ V +K+++  K+  ++   EI+ILE+LR      
Sbjct: 98  RYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDN 157

Query: 91  GPNIITLADIVKDPVSRTPALVFEHVNNTDF----KQLYQTLTDYDIRFYMYEILKALDY 146
             N+I + +           + FE ++   +    K  +Q  +   +R + + IL+ LD 
Sbjct: 158 TMNVIHMLENFT--FRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDA 215

Query: 147 CHSMGIMHRDVKPHNVMIDHEHRK-LRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVD 205
            H   I+H D+KP N+++  + R  +++ID+G + + H  Q     + SR+++ PE+++ 
Sbjct: 216 LHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEH--QRVYTYIQSRFYRAPEVILG 273

Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTED------LYDYID 259
            + Y   +DMWSLGC+LA ++    P   G D  DQL  + ++LG              +
Sbjct: 274 AR-YGMPIDMWSLGCILAELLTGY-PLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKN 331

Query: 260 KYNIELDPRFNDIL----------------GRHSRKRWERFVHSENQHLVSPEALDFLDK 303
             + +  PR+  +                 G+       R   +  +    P  LDFL +
Sbjct: 332 FVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQ 391

Query: 304 LLRYDHQSRLTAREAMEHPYFY 325
            L +D   R+T  +A+ HP+  
Sbjct: 392 CLEWDPAVRMTPGQALRHPWLR 413


>4D28-A nrPDB
          Length = 446

 Score =  245 bits (626), Expect = 2e-65,   Method: Composition-based stats.
 Identities = 69/298 (23%), Positives = 124/298 (41%), Gaps = 52/298 (17%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKI------LKPVKKKKIKREIKILENLRGG 91
            Y++ R +G G +++V  A N    + V +KI      LK     +IKREI I++ +R  
Sbjct: 10  KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH- 68

Query: 92  PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCH 148
           PNI+ L +++         +V E V   +          L + + R Y  +++ A+ +CH
Sbjct: 69  PNIVRLYEVL--ASKSKIYIVLEFVTGGELFDRIVHKGRLKEDESRKYFQQLVDAVAHCH 126

Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEY-NVRVASRYFKGPELLVDYQ 207
           S G+ HRD+KP N+++D  +  L++ D+GL+     G E  N    +  +  PE+L    
Sbjct: 127 SKGVYHRDLKPENLLLDT-NGNLKVSDFGLSALPQEGVELLNDTCGTPNYVAPEVLSGQG 185

Query: 208 MYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDP 267
               + D+WS G +L  ++    PF                     LY  I+    +  P
Sbjct: 186 YDGSAADIWSCGVILFVILAGYLPFSETD--------------LPGLYRKINAAEFDCPP 231

Query: 268 RFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFY 325
            F                        S E    + ++L  + ++R+  +   + P+F 
Sbjct: 232 WF------------------------SAEVKFLIHRILDPNPKTRIQIQGIKKDPWFR 265


>3COM-A nrPDB
          Length = 314

 Score =  245 bits (626), Expect = 2e-65,   Method: Composition-based stats.
 Identities = 64/320 (20%), Positives = 124/320 (38%), Gaps = 46/320 (14%)

Query: 13  TDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP 72
             +     R+    +   +    ++ + ++ KLG G Y  V++AI+    + V +K +  
Sbjct: 5   VQLRNPPRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPV 64

Query: 73  V-KKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ----T 127
               ++I +EI I++     P+++               +V E+        + +    T
Sbjct: 65  ESDLQEIIKEISIMQQC-DSPHVVKYYGSYFKNTD--LWIVMEYCGAGSVSDIIRLRNKT 121

Query: 128 LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQ 186
           LT+ +I   +   LK L+Y H M  +HRD+K  N++++ E    +L D+G+A +      
Sbjct: 122 LTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHA-KLADFGVAGQLTDTMA 180

Query: 187 EYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIA 246
           + N  + + ++  PE++ +   Y+   D+WSLG     M   K P+   H          
Sbjct: 181 KRNTVIGTPFWMAPEVIQEI-GYNCVADIWSLGITAIEMAEGKPPYADIH---------- 229

Query: 247 KVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLR 306
                      I        P F                      L S    DF+ + L 
Sbjct: 230 -------PMRAIFMIPTNPPPTFR------------------KPELWSDNFTDFVKQCLV 264

Query: 307 YDHQSRLTAREAMEHPYFYT 326
              + R TA + ++HP+  +
Sbjct: 265 KSPEQRATATQLLQHPFVRS 284


>4L42-A nrPDB
          Length = 346

 Score =  245 bits (625), Expect = 3e-65,   Method: Composition-based stats.
 Identities = 80/360 (22%), Positives = 142/360 (39%), Gaps = 62/360 (17%)

Query: 32  EWGNQDDYQLVRKLGRGKYSEVFEAINI---TNNEKVVVKILKP-------VKKKKIKRE 81
           E    + ++L+R LG+G Y +VF+   +      +   +K+LK              K E
Sbjct: 13  EKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAE 72

Query: 82  IKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMY 138
             ILE ++  P I+ L    +        L+ E+++  +     +      +    FY+ 
Sbjct: 73  RNILEEVKH-PFIVDLIYAFQ--TGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLA 129

Query: 139 EILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF-YHPGQEYNVRVASRYF 197
           EI  AL + H  GI++RD+KP N+M++H+   ++L D+GL +   H G   +    +  +
Sbjct: 130 EISMALGHLHQKGIIYRDLKPENIMLNHQGH-VKLTDFGLCKESIHDGTVTHTFCGTIEY 188

Query: 198 KGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDY 257
             PE+L+    ++ ++D WSLG ++  M+    PF  G +    + +I            
Sbjct: 189 MAPEILM-RSGHNRAVDWWSLGALMYDMLTGAPPF-TGENRKKTIDKI------------ 234

Query: 258 IDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT--- 314
             K  + L P                            EA D L KLL+ +  SRL    
Sbjct: 235 -LKCKLNLPPYLTQ------------------------EARDLLKKLLKRNAASRLGAGP 269

Query: 315 --AREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLGPLAGSPV 372
             A E   HP+F  +  ++        P      S  ++    S     +P+     S +
Sbjct: 270 GDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTL 329


>4JXF-A nrPDB
          Length = 266

 Score =  244 bits (624), Expect = 4e-65,   Method: Composition-based stats.
 Identities = 64/300 (21%), Positives = 132/300 (44%), Gaps = 54/300 (18%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL------KPVKKKKIKREIKILENLRG 90
           +D+++   LG+G ++ V+ A +I    +V +K++      K    ++++ E+KI   L+ 
Sbjct: 7   EDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKH 66

Query: 91  GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ----TLTDYDIRFYMYEILKALDY 146
            P+I+ L +  +D  S    LV E  +N +  +  +      ++ + R +M++I+  + Y
Sbjct: 67  -PSILELYNYFED--SNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLY 123

Query: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH-PGQEYNVRVASRYFKGPELLVD 205
            HS GI+HRD+   N+++   +  +++ D+GLA     P +++     +  +  PE +  
Sbjct: 124 LHSHGILHRDLTLSNLLLTR-NMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPE-IAT 181

Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIEL 265
              +    D+WSLGCM  +++  + PF       + L ++                    
Sbjct: 182 RSAHGLESDVWSLGCMFYTLLIGRPPF-DTDTVKNTLNKVV------------------- 221

Query: 266 DPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFY 325
                                 E    +S EA D + +LLR +   RL+    ++HP+  
Sbjct: 222 ------------------LADYEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFMS 263


>2I6L-A nrPDB
          Length = 320

 Score =  244 bits (624), Expect = 4e-65,   Method: Composition-based stats.
 Identities = 82/318 (25%), Positives = 152/318 (47%), Gaps = 31/318 (9%)

Query: 29  HVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL---KPVKKKKIKREIKIL 85
           ++  +     Y  ++ LG G    VF A++   +++V +K +    P   K   REIKI+
Sbjct: 3   NIHGFDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKHALREIKII 62

Query: 86  ENLRGGPNIITLADIVKDPVS------------RTPALVFEHVNNTDFKQLYQ--TLTDY 131
             L    NI+ + +I+    S             +  +V E++  TD   + +   L + 
Sbjct: 63  RRL-DHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYME-TDLANVLEQGPLLEE 120

Query: 132 DIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVR 191
             R +MY++L+ L Y HS  ++HRD+KP N+ I+ E   L++ D+GLA    P   +   
Sbjct: 121 HARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGH 180

Query: 192 VA----SRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAK 247
           ++    +++++ P LL+    Y  ++DMW+ GC+ A M+  K   F G    +Q+  I +
Sbjct: 181 LSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKT-LFAGAHELEQMQLILE 239

Query: 248 VLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRY 307
            +    +++   +  + + P +         K   + +       +S EA+DFL+++L +
Sbjct: 240 SI--PVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPG-----ISREAVDFLEQILTF 292

Query: 308 DHQSRLTAREAMEHPYFY 325
               RLTA EA+ HPY  
Sbjct: 293 SPMDRLTAEEALSHPYMS 310


>1VZO-A nrPDB
          Length = 355

 Score =  244 bits (623), Expect = 4e-65,   Method: Composition-based stats.
 Identities = 67/339 (19%), Positives = 141/339 (41%), Gaps = 61/339 (17%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINI---TNNEKVVVKILKP-------VKKKKIKREIKILE 86
           ++++L++ LG G Y +VF    I      +   +K+LK           +  + E ++LE
Sbjct: 54  ENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLE 113

Query: 87  NLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKA 143
           ++R  P ++TL    +        L+ +++N  +        +  T+++++ Y+ EI+ A
Sbjct: 114 HIRQSPFLVTLHYAFQTET--KLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLA 171

Query: 144 LDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYN--VRVASRYFKGPE 201
           L++ H +GI++RD+K  N+++D     + L D+GL++ +   +         +  +  P+
Sbjct: 172 LEHLHKLGIIYRDIKLENILLDSNGHVV-LTDFGLSKEFVADETERAYDFCGTIEYMAPD 230

Query: 202 LLVDY-QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDK 260
           ++      +D ++D WSLG ++  ++    PF    +   Q     ++L +E  Y     
Sbjct: 231 IVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPY----- 285

Query: 261 YNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT-----A 315
                                           +S  A D + +LL  D + RL      A
Sbjct: 286 -----------------------------PQEMSALAKDLIQRLLMKDPKKRLGCGPRDA 316

Query: 316 REAMEHPYFYTVVKDQA---RMGSSSMPGGSTPVSSANM 351
            E  EH +F  +  D     ++ +   P     +  +N 
Sbjct: 317 DEIKEHLFFQKINWDDLAAKKVPAPFKPVIRDELDVSNF 355


>3TXO-A nrPDB
          Length = 353

 Score =  244 bits (623), Expect = 5e-65,   Method: Composition-based stats.
 Identities = 70/343 (20%), Positives = 122/343 (35%), Gaps = 61/343 (17%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPV------KKKKIKREIKILENLRG 90
           D+++ +R LG+G + +V  A      +   VK+LK          +    E +IL   R 
Sbjct: 23  DNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARN 82

Query: 91  GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYC 147
            P +  L    + P       V E VN  D     Q      +   RFY  EI+ AL + 
Sbjct: 83  HPFLTQLFCCFQTP--DRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFL 140

Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF-YHPGQEYNVRVASRYFKGPELLVDY 206
           H  GI++RD+K  NV++DHE    +L D+G+ +     G        +  +  PE+L + 
Sbjct: 141 HDKGIIYRDLKLDNVLLDHEGH-CKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEM 199

Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 266
            +Y  ++D W++G +L  M+    PF   +++         +L  E +Y           
Sbjct: 200 -LYGPAVDWWAMGVLLYEMLCGHAPFEAENED----DLFEAILNDEVVY----------- 243

Query: 267 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTA------REAME 320
                                     +  +A   L   +  +   RL +         + 
Sbjct: 244 -----------------------PTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILR 280

Query: 321 HPYFYTVVKDQAR---MGSSSMPGGSTPVSSANMMSGISSVPT 360
           HP+F  +   Q     +     P   +    +N          
Sbjct: 281 HPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEP 323


>4D2V-A nrPDB
          Length = 356

 Score =  244 bits (623), Expect = 5e-65,   Method: Composition-based stats.
 Identities = 71/310 (22%), Positives = 133/310 (42%), Gaps = 51/310 (16%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP----VKKKKIKREIKILENLRGGPNI 94
           Y+L   +G G +++V  A +I   E V +KI+          +IK EI+ L+NLR   +I
Sbjct: 31  YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNLRHQ-HI 89

Query: 95  ITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCHSMG 151
             L  +++   +    +V E+    +          L++ + R    +I+ A+ Y HS G
Sbjct: 90  CQLYHVLE--TANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQG 147

Query: 152 IMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYN--VRVASRYFKGPELLVDYQMY 209
             HRD+KP N++ D E+ KL+LID+GL       ++Y+      +  +  PEL+      
Sbjct: 148 YAHRDLKPENLLFD-EYHKLKLIDFGLCAKPKGNKDYHLQACCGALAYAAPELIQGKSYL 206

Query: 210 DYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRF 269
               D+WS+G +L  ++    PF    D+      +AK++                    
Sbjct: 207 GSEADVWSMGILLYVLMCGFLPF----DDDTAAALVAKIM-------------------- 242

Query: 270 NDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 329
               G++   +W           +SP ++  L ++L+ D + R++ +  + HP+      
Sbjct: 243 ---RGKYDVPKW-----------LSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYN 288

Query: 330 DQARMGSSSM 339
                 S + 
Sbjct: 289 YPVEWQSKNP 298


>2UV2-A nrPDB
          Length = 325

 Score =  244 bits (622), Expect = 7e-65,   Method: Composition-based stats.
 Identities = 72/311 (23%), Positives = 131/311 (42%), Gaps = 51/311 (16%)

Query: 25  DYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKR---E 81
            YE    +   +D ++++ +LG G + +V++A N   +     K++    +++++    E
Sbjct: 25  QYEHVTRDLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVE 84

Query: 82  IKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNT----DFKQLYQTLTDYDIRFYM 137
           I IL +    PNI+ L D           ++ E            +L + LT+  I+   
Sbjct: 85  IDILASC-DHPNIVKLLDAF--YYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVC 141

Query: 138 YEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGL-AEFYHPGQEYNVRVASRY 196
            + L AL+Y H   I+HRD+K  N++   +   ++L D+G+ A+     Q  +  + + Y
Sbjct: 142 KQTLDALNYLHDNKIIHRDLKAGNILFTLDG-DIKLADFGVSAKNTRTIQRRDSFIGTPY 200

Query: 197 FKGPELLV----DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTE 252
           +  PE+++      + YDY  D+WSLG  L  M    EP  H  +    L++IAK     
Sbjct: 201 WMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAE-IEPPHHELNPMRVLLKIAK----- 254

Query: 253 DLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSR 312
                            ++        RW            S    DFL K L  +  +R
Sbjct: 255 -----------------SEPPTLAQPSRW------------SSNFKDFLKKCLEKNVDAR 285

Query: 313 LTAREAMEHPY 323
            T  + ++HP+
Sbjct: 286 WTTSQLLQHPF 296


>4CQG-A nrPDB
          Length = 331

 Score =  243 bits (621), Expect = 7e-65,   Method: Composition-based stats.
 Identities = 70/310 (22%), Positives = 133/310 (42%), Gaps = 51/310 (16%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP----VKKKKIKREIKILENLRGGPNI 94
           Y+L   +G G +++V  A ++   E V +KI+          ++K EI  L++LR   +I
Sbjct: 11  YELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGSDLPRVKTEIDALKSLRHQ-HI 69

Query: 95  ITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCHSMG 151
             L  +++        +V E+    +          L++ + R    +IL A+ Y HS G
Sbjct: 70  CQLYHVLE--TKNKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQILSAVAYVHSQG 127

Query: 152 IMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVR--VASRYFKGPELLVDYQMY 209
             HRD+KP N++ D E+ KL+LID+GL       ++Y+++    S  +  PEL+      
Sbjct: 128 YAHRDLKPENLLFD-ENHKLKLIDFGLCAKPKGNKDYHLQECCGSLAYAAPELIQGKSYL 186

Query: 210 DYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRF 269
               D+WS+G +L  ++    PF    D+ + +    K++                    
Sbjct: 187 GSEADVWSMGILLYVLMCGFLPF----DDDNVMALYKKIM-------------------- 222

Query: 270 NDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 329
               G++   +W           +SP ++  L ++L+ D + R++ R  + HP+      
Sbjct: 223 ---RGKYEVPKW-----------LSPSSILLLQQMLQVDPKKRISMRNLLNHPWVMQDYS 268

Query: 330 DQARMGSSSM 339
                 S + 
Sbjct: 269 CPVEWQSKTP 278


>4RLP-A nrPDB
          Length = 288

 Score =  243 bits (620), Expect = 1e-64,   Method: Composition-based stats.
 Identities = 75/324 (23%), Positives = 132/324 (40%), Gaps = 62/324 (19%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINI---TNNEKVVVKILKP-------VKKKKIKREIKIL 85
            + ++L+R LG+G Y +VF+   +      +   +K+LK              K E  IL
Sbjct: 4   PECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNIL 63

Query: 86  ENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILK 142
           E ++  P I+ L    +        L+ E+++  +     +      +    FY+ EI  
Sbjct: 64  EEVKH-PFIVDLIYAFQ--TGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISM 120

Query: 143 ALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF-YHPGQEYNVRVASRYFKGPE 201
           AL + H  GI++RD+KP N+M++H+   ++L D+GL +   H G   +    +  +  PE
Sbjct: 121 ALGHLHQKGIIYRDLKPENIMLNHQGH-VKLTDFGLCKESIHDGTVTHTFCGTIEYMAPE 179

Query: 202 LLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKY 261
           +L+    ++ ++D WSLG ++  M+    PF  G +    + +I              K 
Sbjct: 180 ILM-RSGHNRAVDWWSLGALMYDMLTGAPPF-TGENRKKTIDKI-------------LKC 224

Query: 262 NIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT-----AR 316
            + L P                            EA D L KLL+ +  SRL      A 
Sbjct: 225 KLNLPPYLTQ------------------------EARDLLKKLLKRNAASRLGAGPGDAG 260

Query: 317 EAMEHPYFYTVVKDQARMGSSSMP 340
           E   HP+F  +  ++        P
Sbjct: 261 EVQAHPFFRHINWEELLARKVEPP 284


>6FD3-A nrPDB
          Length = 300

 Score =  243 bits (620), Expect = 1e-64,   Method: Composition-based stats.
 Identities = 68/294 (23%), Positives = 127/294 (43%), Gaps = 46/294 (15%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPV---KKKKIKREIKILENLRGGPNI 94
            Y    K+G+G    V+ A++I   ++V +K +      KK+ I  EI ++   +  PNI
Sbjct: 23  KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKN-PNI 81

Query: 95  ITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ--TLTDYDIRFYMYEILKALDYCHSMGI 152
           +   D     V     +V E++       +     + +  I     E L+ALD+ HS  +
Sbjct: 82  VNYLDSY--LVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQV 139

Query: 153 MHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ-EYNVRVASRYFKGPELLVDYQMYDY 211
           +HRD+K  N+++  +   ++L D+G      P Q + +  V + Y+  PE++   + Y  
Sbjct: 140 IHRDIKSDNILLGMDG-SVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVV-TRKAYGP 197

Query: 212 SLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFND 271
            +D+WSLG M   M+  + P+   ++N  + + +    GT +L                 
Sbjct: 198 KVDIWSLGIMAIEMVEGEPPYL--NENPLRALYLIATNGTPEL----------------- 238

Query: 272 ILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFY 325
                           +N   +S    DFL++ L  D   R +A+E ++HP+  
Sbjct: 239 ----------------QNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLK 276


>1NY3-A nrPDB
          Length = 400

 Score =  243 bits (620), Expect = 1e-64,   Method: Composition-based stats.
 Identities = 81/366 (22%), Positives = 143/366 (39%), Gaps = 67/366 (18%)

Query: 37  DDYQLV-RKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNII 95
           DDY++  + LG G   +V +  N    EK  +K+L      K +RE+++       P+I+
Sbjct: 61  DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML--QDCPKARREVELHWRASQCPHIV 118

Query: 96  TLADIVKD--PVSRTPALVFEHVNNTDFKQLYQ-----TLTDYDIRFYMYEILKALDYCH 148
            + D+ ++     +   +V E ++  +     Q       T+ +    M  I +A+ Y H
Sbjct: 119 RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 178

Query: 149 SMGIMHRDVKPHNVMIDHE--HRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDY 206
           S+ I HRDVKP N++   +  +  L+L D+G A+             + Y+  PE+L   
Sbjct: 179 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVL-GP 237

Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 266
           + YD S DMWSLG ++  ++    PF+  H           +  +  +   I     E  
Sbjct: 238 EKYDKSCDMWSLGVIMYILLCGYPPFYSNH----------GLAISPGMKTRIRMGQYEFP 287

Query: 267 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYT 326
                               +     VS E    +  LL+ +   R+T  E M HP+   
Sbjct: 288 --------------------NPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI-- 325

Query: 327 VVKDQARMGSSSMPGGSTPVSSANMMSGIS------SVPTPSPLG-------PLAGSPVI 373
                  M S+ +P   TP+ ++ ++               S L         +    + 
Sbjct: 326 -------MQSTKVP--QTPLHTSRVLKEDKERWEDVKEEMTSALATMRVDYEQIKIKKIE 376

Query: 374 AAANPL 379
            A+NPL
Sbjct: 377 DASNPL 382


>4CZT-A nrPDB
          Length = 464

 Score =  242 bits (619), Expect = 2e-64,   Method: Composition-based stats.
 Identities = 68/300 (22%), Positives = 126/300 (42%), Gaps = 54/300 (18%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK------KKIKREIKILENLRGG 91
            Y+L R LG G +++V  A N+ N + V +K++   K        +IKREI  ++ ++  
Sbjct: 12  KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH- 70

Query: 92  PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYCH 148
           PN+I + +++          V E V   +      +   L + + R Y  +++ A+DYCH
Sbjct: 71  PNVIRMFEVMASKT--KIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCH 128

Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA---EFYHPGQEYNVRVASRYFKGPELLVD 205
           S G+ HRD+KP N+++D  +  L++ D+GL+   +        +    +  +  PE++ +
Sbjct: 129 SRGVYHRDLKPENLLLDA-NGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINN 187

Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIEL 265
                   D+WS G +L  ++    PF   +                 LY  I K     
Sbjct: 188 KGYDGAKADLWSCGVILFVLMAGYLPFEDSN--------------LTSLYKKIFKAEFTC 233

Query: 266 DPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFY 325
            P F                        S  A   + ++L  +  +R+T  E +E+ +F 
Sbjct: 234 PPWF------------------------SASAKKLIKRILDPNPATRITFAEVIENEWFK 269


>5D7A-A nrPDB
          Length = 308

 Score =  242 bits (618), Expect = 2e-64,   Method: Composition-based stats.
 Identities = 69/309 (22%), Positives = 128/309 (41%), Gaps = 53/309 (17%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPV--KKKKIKREIKILENLRGGPNIIT 96
           ++LV  +G G Y +V++  ++   +   +K++     ++++IK+EI +L+      NI T
Sbjct: 19  FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIAT 78

Query: 97  LADIV--KDP--VSRTPALVFEHVNNTDFKQLYQ-----TLTDYDIRFYMYEILKALDYC 147
                  K+P  +     LV E         L +     TL +  I +   EIL+ L + 
Sbjct: 79  YYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHL 138

Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGL-AEFYHPGQEYNVRVASRYFKGPELLVDY 206
           H   ++HRD+K  NV++  E+ +++L+D+G+ A+        N  + + Y+  PE++   
Sbjct: 139 HQHKVIHRDIKGQNVLLT-ENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACD 197

Query: 207 QM----YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYN 262
           +     YD+  D+WSLG     M     P                      L D      
Sbjct: 198 ENPDATYDFKSDLWSLGITAIEMAEGAPP----------------------LCDMHPMRA 235

Query: 263 IELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHP 322
           + L PR  +   R   K+W            S +   F++  L  +H  R    + M+HP
Sbjct: 236 LFLIPR--NPAPRLKSKKW------------SKKFQSFIESCLVKNHSQRPATEQLMKHP 281

Query: 323 YFYTVVKDQ 331
           +      ++
Sbjct: 282 FIRDQPNER 290


>2OZA-A nrPDB
          Length = 356

 Score =  242 bits (617), Expect = 2e-64,   Method: Composition-based stats.
 Identities = 81/366 (22%), Positives = 143/366 (39%), Gaps = 67/366 (18%)

Query: 37  DDYQLV-RKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNII 95
           DDY++  + LG G   +V +  N    EK  +K+L      K +RE+++       P+I+
Sbjct: 17  DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML--QDCPKARREVELHWRASQCPHIV 74

Query: 96  TLADIVKD--PVSRTPALVFEHVNNTDFKQLYQ-----TLTDYDIRFYMYEILKALDYCH 148
            + D+ ++     +   +V E ++  +     Q       T+ +    M  I +A+ Y H
Sbjct: 75  RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 134

Query: 149 SMGIMHRDVKPHNVMIDHE--HRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDY 206
           S+ I HRDVKP N++   +  +  L+L D+G A+             + Y+  PE+L   
Sbjct: 135 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVL-GP 193

Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 266
           + YD S DMWSLG ++  ++    PF+  H           +  +  +   I     E  
Sbjct: 194 EKYDKSCDMWSLGVIMYILLCGYPPFYSNH----------GLAISPGMKTRIRMGQYEFP 243

Query: 267 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYT 326
                               +     VS E    +  LL+ +   R+T  E M HP+   
Sbjct: 244 --------------------NPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI-- 281

Query: 327 VVKDQARMGSSSMPGGSTPVSSANMMSGIS------SVPTPSPLG-------PLAGSPVI 373
                  M S+ +P   TP+ ++ ++               S L         +    + 
Sbjct: 282 -------MQSTKVP--QTPLHTSRVLKEDKERWEDVKEEMTSALATMRVDYEQIKIKKIE 332

Query: 374 AAANPL 379
            A+NPL
Sbjct: 333 DASNPL 338


>3KA0-A nrPDB
          Length = 320

 Score =  241 bits (616), Expect = 3e-64,   Method: Composition-based stats.
 Identities = 75/328 (22%), Positives = 134/328 (40%), Gaps = 54/328 (16%)

Query: 37  DDYQLV-RKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNII 95
           DDY++  + LG G   +V +  N    EK  +K+L      K +RE+++       P+I+
Sbjct: 15  DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML--QDCPKARREVELHWRASQCPHIV 72

Query: 96  TLADIVKD--PVSRTPALVFEHVNNTDFKQLYQ-----TLTDYDIRFYMYEILKALDYCH 148
            + D+ ++     +   +V E ++  +     Q       T+ +    M  I +A+ Y H
Sbjct: 73  RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 132

Query: 149 SMGIMHRDVKPHNVMIDHE--HRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDY 206
           S+ I HRDVKP N++   +  +  L+L D+G A+             + Y+  PE+L   
Sbjct: 133 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTEPCYTPYYVAPEVL-GP 191

Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 266
           + YD S DMWSLG ++  ++    PF+  H           +  +  +   I     E  
Sbjct: 192 EKYDKSCDMWSLGVIMYILLCGYPPFYSNH----------GLAISPGMKTRIRMGQYEFP 241

Query: 267 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYT 326
                               +     VS E    +  LL+ +   R+T  E M HP+   
Sbjct: 242 --------------------NPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI-- 279

Query: 327 VVKDQARMGSSSMPGGSTPVSSANMMSG 354
                  M S+ +P   TP+ ++ ++  
Sbjct: 280 -------MQSTKVP--QTPLHTSRVLKE 298


>6CKI-A nrPDB
          Length = 316

 Score =  241 bits (615), Expect = 4e-64,   Method: Composition-based stats.
 Identities = 72/322 (22%), Positives = 134/322 (41%), Gaps = 42/322 (13%)

Query: 36  QDDYQLVR-KLGRGKYSEVFEAINITNNEKVVVKILKPVK---KKKIKREIKILENLRGG 91
           +D YQL    LG G ++ V   IN+  +++  VKI++      + ++ RE+++L   +G 
Sbjct: 11  EDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQCQGH 70

Query: 92  PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYCH 148
            N++    I          LVFE +                + +    + ++  ALD+ H
Sbjct: 71  RNVL--ELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLH 128

Query: 149 SMGIMHRDVKPHNVMIDHEHRK--LRLIDWGLAEFYH--------PGQEYNVRVASRYFK 198
           + GI HRD+KP N++ +H ++   +++ D+GL                E      S  + 
Sbjct: 129 NKGIAHRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPELLTPCGSAEYM 188

Query: 199 GPELL----VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDL 254
            PE++     +  +YD   D+WSLG +L  ++    PF                 G++  
Sbjct: 189 APEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPF-------------VGRCGSDCG 235

Query: 255 YDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT 314
           +D       E  P   ++L    ++    F   +  H +S  A D + KLL  D + RL+
Sbjct: 236 WD-----RGEACPACQNMLFESIQEGKYEFPDKDWAH-ISCAAKDLISKLLVRDAKQRLS 289

Query: 315 AREAMEHPYFYTVVKDQARMGS 336
           A + ++HP+      +      
Sbjct: 290 AAQVLQHPWVQGCAPENTLPTP 311


>5N23-A nrPDB
          Length = 352

 Score =  241 bits (615), Expect = 4e-64,   Method: Composition-based stats.
 Identities = 71/345 (20%), Positives = 135/345 (39%), Gaps = 61/345 (17%)

Query: 25  DYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKR---- 80
            +ES      + D ++ +R LG G +  V    +        +KIL   K  K+K+    
Sbjct: 30  KWESPAQNTAHLDQFERIRTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHT 89

Query: 81  --EIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRF 135
             E +I +     P ++ L    KD  +    +V E+    +     +     ++   RF
Sbjct: 90  LNEKRI-QQAVNFPFLVKLEFSFKD--NSNLYMVLEYAPGGEMFSHLRRIGRFSEPHARF 146

Query: 136 YMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASR 195
           Y  +I+   +Y HS+ +++RD+KP N++ID +   +++ D+G A+    G+       + 
Sbjct: 147 YAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY-IKVADFGFAKRVK-GRTPWTLCGTP 204

Query: 196 YFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLY 255
            +  PE+++  + Y+ ++D W+LG ++  M     PFF      DQ ++I         Y
Sbjct: 205 EYLAPEIILS-KGYNKAVDWWALGVLIYEMAAGYPPFF-----ADQPIQI---------Y 249

Query: 256 DYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRL-- 313
           + I    +     F                        S +  D L  LL+ D   R   
Sbjct: 250 EKIVSGKVRFPSHF------------------------SSDLKDLLRNLLQVDLTKRFGN 285

Query: 314 ---TAREAMEHPYFYTVVK---DQARMGSSSMPGGSTPVSSANMM 352
                 +   H +F T       Q ++ +  +P    P  ++N  
Sbjct: 286 LKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFD 330


>4RA4-A nrPDB
          Length = 355

 Score =  241 bits (614), Expect = 6e-64,   Method: Composition-based stats.
 Identities = 75/366 (20%), Positives = 123/366 (33%), Gaps = 63/366 (17%)

Query: 20  PREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPV------ 73
           P E     S+ ++     D+  +  LG+G + +V  A      E   +KILK        
Sbjct: 3   PSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDD 62

Query: 74  KKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ---TLTD 130
             +    E ++L  L   P +  L    +         V E+VN  D     Q      +
Sbjct: 63  DVECTMVEKRVLALLDKPPFLTQLHSCFQ--TVDRLYFVMEYVNGGDLMYHIQQVGKFKE 120

Query: 131 YDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF-YHPGQEYN 189
               FY  EI   L + H  GI++RD+K  NVM+D E   +++ D+G+ +     G    
Sbjct: 121 PQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGH-IKIADFGMCKEHMMDGVTTR 179

Query: 190 VRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVL 249
               +  +  PE++  YQ Y  S+D W+ G +L  M+  + PF  G D  +    I +  
Sbjct: 180 TFCGTPDYIAPEIIA-YQPYGKSVDWWAYGVLLYEMLAGQPPF-DGEDEDELFQSIME-- 235

Query: 250 GTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDH 309
                                               +      +S EA+     L+    
Sbjct: 236 -----------------------------------HNVSYPKSLSKEAVSICKGLMTKHP 260

Query: 310 QSRLTA-----REAMEHPYFYTVVKDQARMGSSSMP------GGSTPVSSANMMSGISSV 358
             RL       R+  EH +F  +  ++        P      G            G   +
Sbjct: 261 AKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVSGKGAENFDKFFTRGQPVL 320

Query: 359 PTPSPL 364
             P  L
Sbjct: 321 TPPDQL 326


>3A8W-A nrPDB
          Length = 345

 Score =  240 bits (612), Expect = 1e-63,   Method: Composition-based stats.
 Identities = 83/345 (24%), Positives = 136/345 (39%), Gaps = 56/345 (16%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPV------KKKKIKREIKILENLRG 90
            D+ L+R +GRG Y++V        +    +K++K            ++ E  + E    
Sbjct: 9   QDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASN 68

Query: 91  GPNIITLADIVKDPVSRTPALVFEHVNNTDFK---QLYQTLTDYDIRFYMYEILKALDYC 147
            P ++ L    +         V E+VN  D     Q  + L +   RFY  EI  AL+Y 
Sbjct: 69  HPFLVGLHSCFQ--TESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYL 126

Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF-YHPGQEYNVRVASRYFKGPELLVDY 206
           H  GI++RD+K  NV++D E   ++L D+G+ +    PG   +    +  +  PE+L   
Sbjct: 127 HERGIIYRDLKLDNVLLDSEGH-IKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRG- 184

Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFF--HGHDNYDQLVRIAKVLGTEDLYDYIDKYNIE 264
           + Y +S+D W+LG ++  M+  + PF      DN DQ           +  DY+ +  +E
Sbjct: 185 EDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQ-----------NTEDYLFQVILE 233

Query: 265 LDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTA------REA 318
              R    L                    S +A   L   L  D + RL         + 
Sbjct: 234 KQIRIPRSL--------------------SVKAASVLKSFLNKDPKERLGCHPQTGFADI 273

Query: 319 MEHPYFYTVVKD---QARMGSSSMPGGSTPVSSANMMSGISSVPT 360
             HP+F  V  D   Q ++     P  S      N  S  ++ P 
Sbjct: 274 QGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPV 318


>6CMJ-A nrPDB
          Length = 321

 Score =  239 bits (611), Expect = 1e-63,   Method: Composition-based stats.
 Identities = 69/327 (21%), Positives = 137/327 (41%), Gaps = 63/327 (19%)

Query: 22  EYWDYESHVVEWGNQ------DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK 75
           E   ++ H V           D Y L  ++G+G Y  V  A N  +N    +K+L   K 
Sbjct: 13  ENLYFQGHHVSITGMQDCVQLDQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKL 72

Query: 76  --------------KKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDF 121
                         +++ +EI IL+ L   PN++ L +++ DP      +VFE VN    
Sbjct: 73  IRQAGGCIQPRGPIEQVYQEIAILKKL-DHPNVVKLVEVLDDPNEDHLYMVFELVNQGPV 131

Query: 122 KQL--YQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA 179
            ++   + L++   RFY  +++K ++Y H   I+HRD+KP N+++  +   +++ D+G++
Sbjct: 132 MEVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGH-IKIADFGVS 190

Query: 180 EFYH-PGQEYNVRVASRYFKGPELLVDYQMY--DYSLDMWSLGCMLASMIFRKEPFFHGH 236
             +       +  V +  F  PE L + +      +LD+W++G  L   +F + PF    
Sbjct: 191 NEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMD-- 248

Query: 237 DNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPE 296
                     +++                             K   + +   +Q  ++ +
Sbjct: 249 ---------ERIMC-------------------------LHSKIKSQALEFPDQPDIAED 274

Query: 297 ALDFLDKLLRYDHQSRLTAREAMEHPY 323
             D + ++L  + +SR+   E   HP+
Sbjct: 275 LKDLITRMLDKNPESRIVVPEIKLHPW 301


>5X8I-B nrPDB
          Length = 346

 Score =  239 bits (611), Expect = 1e-63,   Method: Composition-based stats.
 Identities = 75/333 (22%), Positives = 146/333 (43%), Gaps = 43/333 (12%)

Query: 38  DYQLVRKLGRGKYSEVFEAI-NITNNEKVVVKILKPVKK--KKIKREIKILENLRG-GPN 93
            Y++V  LG G + +V E I +      V VKI+K V +  +  + EI++LE+L    PN
Sbjct: 14  RYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPN 73

Query: 94  ----IITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ----TLTDYDIRFYMYEILKALD 145
                + + +  +        +VFE +  + +  + +          IR   Y+I K+++
Sbjct: 74  STFRCVQMLEWFEH--HGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVN 131

Query: 146 YCHSMGIMHRDVKPHNVMIDHE------------------HRKLRLIDWGLAEFYHPGQE 187
           + HS  + H D+KP N++                      +  ++++D+G A +    + 
Sbjct: 132 FLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATY--DDEH 189

Query: 188 YNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAK 247
           ++  V++R+++ PE+++    +    D+WS+GC+L         F   HD+ + L  + +
Sbjct: 190 HSTLVSTRHYRAPEVILAL-GWSQPCDVWSIGCILIEYYLGFTVF-PTHDSKEHLAMMER 247

Query: 248 VLGTEDLYDYIDKYNIE------LDPRFNDILGRHSRKRWERFVHSENQHLVSPE-ALDF 300
           +LG    +        +      LD   +   GR+  +  +          V  E   D 
Sbjct: 248 ILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQDVEHERLFDL 307

Query: 301 LDKLLRYDHQSRLTAREAMEHPYFYTVVKDQAR 333
           + K+L YD   R+T REA++HP+F  + K    
Sbjct: 308 IQKMLEYDPAKRITLREALKHPFFDLLKKSILE 340


>4WB7-A nrPDB
          Length = 405

 Score =  239 bits (610), Expect = 1e-63,   Method: Composition-based stats.
 Identities = 71/345 (20%), Positives = 136/345 (39%), Gaps = 62/345 (17%)

Query: 25  DYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKR---- 80
            +ES      + D ++ ++ LG G +  V    +        +KIL   K  K+K+    
Sbjct: 84  KWESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHT 143

Query: 81  --EIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRF 135
             E +IL+ +   P ++ L    KD  +    +V E+V   +     +     ++   RF
Sbjct: 144 LNEKRILQAV-NFPFLVKLEFSFKD--NSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARF 200

Query: 136 YMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASR 195
           Y  +I+   +Y HS+ +++RD+KP N++ID +   +++ D+G A+             + 
Sbjct: 201 YAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY-IQVTDFGFAKRVK--GRTWTLCGTP 257

Query: 196 YFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLY 255
            +  PE+++  + Y+ ++D W+LG ++  M     PFF      DQ ++I         Y
Sbjct: 258 EYLAPEIILS-KGYNKAVDWWALGVLIYEMAAGYPPFF-----ADQPIQI---------Y 302

Query: 256 DYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRL-- 313
           + I    +     F                        S +  D L  LL+ D   R   
Sbjct: 303 EKIVSGKVRFPSHF------------------------SSDLKDLLRNLLQVDLTKRFGN 338

Query: 314 ---TAREAMEHPYFYTVVK---DQARMGSSSMPGGSTPVSSANMM 352
                 +   H +F T       Q ++ +  +P    P  ++N  
Sbjct: 339 LKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFD 383


>2Z7Q-A nrPDB
          Length = 321

 Score =  239 bits (610), Expect = 2e-63,   Method: Composition-based stats.
 Identities = 68/342 (19%), Positives = 135/342 (39%), Gaps = 63/342 (18%)

Query: 32  EWGNQDDYQLVRKLGRGKYSEVFEAINI---TNNEKVVVKILKPV-----KKKKIKREIK 83
           E  +   ++L++ LG+G + +VF    +    +     +K+LK        + + K E  
Sbjct: 23  EKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERD 82

Query: 84  ILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEI 140
           IL ++   P ++ L    +        L+ + +   D           T+ D++FY+ E+
Sbjct: 83  ILADV-NHPFVVKLHYAFQ--TEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAEL 139

Query: 141 LKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF-YHPGQEYNVRVASRYFKG 199
              LD+ HS+GI++RD+KP N+++D E   ++L D+GL++      ++      +  +  
Sbjct: 140 ALGLDHLHSLGIIYRDLKPENILLDEEGH-IKLTDFGLSKEAIDHEKKAYSFCGTVEYMA 198

Query: 200 PELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYID 259
           PE++ + Q + +S D WS G ++  M+    PF  G D  + +  I K            
Sbjct: 199 PEVV-NRQGHSHSADWWSYGVLMFEMLTGSLPF-QGKDRKETMTLILK------------ 244

Query: 260 KYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRL-----T 314
                                            +S EA   L  L + +  +RL      
Sbjct: 245 -------------------------AKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDG 279

Query: 315 AREAMEHPYFYTVVKDQA---RMGSSSMPGGSTPVSSANMMS 353
           A E   H ++ T+  ++     +     P  + P  +    +
Sbjct: 280 AEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDT 321


>5X3F-B nrPDB
          Length = 393

 Score =  239 bits (609), Expect = 2e-63,   Method: Composition-based stats.
 Identities = 70/345 (20%), Positives = 135/345 (39%), Gaps = 62/345 (17%)

Query: 25  DYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKR---- 80
            +E+        D +  ++ LG G +  V    +  +     +KIL   K  K+K+    
Sbjct: 72  KWETPSQNTAQLDQFDRIKTLGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQIEHT 131

Query: 81  --EIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRF 135
             E +IL+ +   P ++ L    KD  +    +V E+V   +     +     ++   RF
Sbjct: 132 LNEKRILQAV-NFPFLVKLEFSFKD--NSNLYMVMEYVAGGEMFSHLRRIGRFSEPHARF 188

Query: 136 YMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASR 195
           Y  +I+   +Y HS+ +++RD+KP N++ID +   +++ D+G A+             + 
Sbjct: 189 YAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY-IQVTDFGFAKRVK--GRTWTLCGTP 245

Query: 196 YFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLY 255
            +  PE+++  + Y+ ++D W+LG ++  M     PFF      DQ ++I         Y
Sbjct: 246 EYLAPEIILS-KGYNKAVDWWALGVLIYEMAAGYPPFF-----ADQPIQI---------Y 290

Query: 256 DYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRL-- 313
           + I    +     F                        S +  D L  LL+ D   R   
Sbjct: 291 EKIVSGKVRFPSHF------------------------SSDLKDLLRNLLQVDLTKRFGN 326

Query: 314 ---TAREAMEHPYFYTVVK---DQARMGSSSMPGGSTPVSSANMM 352
                 +   H +F T       Q ++ +  +P    P  ++N  
Sbjct: 327 LKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFD 371


>3FXW-A nrPDB
          Length = 336

 Score =  239 bits (609), Expect = 2e-63,   Method: Composition-based stats.
 Identities = 71/305 (23%), Positives = 121/305 (39%), Gaps = 44/305 (14%)

Query: 32  EWGNQDDYQLVR-KLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRG 90
           ++   DDYQL +  LG G   +V E  +    +K  +K+L      K ++E+       G
Sbjct: 23  KYAVTDDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLL--YDSPKARQEVDHHWQASG 80

Query: 91  GPNIITLADIVKD--PVSRTPALVFEHVNNTDFKQLYQ-----TLTDYDIRFYMYEILKA 143
           GP+I+ + D+ ++     R   ++ E +   +     Q       T+ +    M +I  A
Sbjct: 81  GPHIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTA 140

Query: 144 LDYCHSMGIMHRDVKPHNVMIDHEHRK--LRLIDWGLAEFYHPGQEYNVRVASRYFKGPE 201
           + + HS  I HRDVKP N++   + +   L+L D+G A+             + Y+  PE
Sbjct: 141 IQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKET-TQNALQTPCYTPYYVAPE 199

Query: 202 LLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKY 261
           +L   + YD S DMWSLG ++  ++    PF+                      +     
Sbjct: 200 VL-GPEKYDKSCDMWSLGVIMYILLCGFPPFYS---------------------NTGQAI 237

Query: 262 NIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEH 321
           +  +  R            W           VS +A   +  LL+ D   RLT  + M H
Sbjct: 238 SPGMKRRIRLGQYGFPNPEWSE---------VSEDAKQLIRLLLKTDPTERLTITQFMNH 288

Query: 322 PYFYT 326
           P+   
Sbjct: 289 PWINQ 293


>6FDY-U nrPDB
          Length = 276

 Score =  238 bits (608), Expect = 3e-63,   Method: Composition-based stats.
 Identities = 76/303 (25%), Positives = 124/303 (40%), Gaps = 51/303 (16%)

Query: 33  WGNQ--DDYQLVRKLGRGKYSEVFEAI-NITNNEKVVVKI-----LKPVKKKKIKREIKI 84
           WG    D + L  +LG G Y+ V++A       E V +K      L     + +  EI+I
Sbjct: 5   WGPPRLDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEI 64

Query: 85  LENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEIL 141
           L+ +R  P+I+ L D   D  S    L+ E     D  +   T   L +   R +M ++ 
Sbjct: 65  LKGIRH-PHIVQLKDFQWD--SDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLA 121

Query: 142 KALDYCHSMGIMHRDVKPHNVMIDH-EHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGP 200
            AL + H   I H D+KP N+++   E   L+L D+G A+   P  E +V   S  +  P
Sbjct: 122 SALQFLHERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAP 181

Query: 201 ELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDK 260
           E++   Q YD  +D+WS+G +L   +F + PF                            
Sbjct: 182 EMVCQRQ-YDARVDLWSMGVILYEALFGQPPFAS-------------------------- 214

Query: 261 YNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAME 320
                            + R  R +    + L+S +  D L +LL  D   R++ ++   
Sbjct: 215 ---------RSFSELEEKIRSNRVIELPLRPLLSRDCRDLLQRLLERDPSRRISFQDFFA 265

Query: 321 HPY 323
           HP+
Sbjct: 266 HPW 268


>4LG4-A nrPDB
          Length = 299

 Score =  236 bits (603), Expect = 9e-63,   Method: Composition-based stats.
 Identities = 63/302 (20%), Positives = 120/302 (39%), Gaps = 46/302 (15%)

Query: 31  VEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPV-KKKKIKREIKILENLR 89
           +    ++ + ++ KLG G Y  VF+AI+  + + V +K +      ++I +EI I++   
Sbjct: 5   LTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQC- 63

Query: 90  GGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ----TLTDYDIRFYMYEILKALD 145
             P ++               +V E+        + +    TL + +I   +   LK L+
Sbjct: 64  DSPYVVKYYGSYFKNTD--LWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLE 121

Query: 146 YCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLV 204
           Y H M  +HR++K  N++++ E    +L D+G+A +      + N  + + ++  PE++ 
Sbjct: 122 YLHFMRKIHRNIKAGNILLNTEGHA-KLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQ 180

Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIE 264
           +   Y+   D+WSLG     M   K P+   H                     I      
Sbjct: 181 EI-GYNCVADIWSLGITSIEMAEGKPPYADIH-----------------PMRAIFMIPTN 222

Query: 265 LDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324
             P F                      L S +  DF+ K L  + + R TA + ++HP+ 
Sbjct: 223 PPPTFR------------------KPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFI 264

Query: 325 YT 326
             
Sbjct: 265 KN 266


>3DAK-A nrPDB
          Length = 290

 Score =  236 bits (603), Expect = 1e-62,   Method: Composition-based stats.
 Identities = 59/312 (18%), Positives = 117/312 (37%), Gaps = 53/312 (16%)

Query: 35  NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK----KIKREIKILENLRG 90
           N+DDY+L   +G G  + V  A      EKV +K +   K +    ++ +EI+ +     
Sbjct: 8   NRDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQC-H 66

Query: 91  GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ-----------TLTDYDIRFYMYE 139
            PNI++        V     LV + ++      + +            L +  I   + E
Sbjct: 67  HPNIVSYYTSF--VVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILRE 124

Query: 140 ILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPG------QEYNVRVA 193
           +L+ L+Y H  G +HRDVK  N+++  +   +++ D+G++ F   G      +     V 
Sbjct: 125 VLEGLEYLHKNGQIHRDVKAGNILLGEDG-SVQIADFGVSAFLATGGDITRNKVRKTFVG 183

Query: 194 SRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTED 253
           +  +  PE++   + YD+  D+WS G     +     P+                     
Sbjct: 184 TPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYH----------------KYPP 227

Query: 254 LYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRL 313
           +   +     +       +  +   K++ +                 +   L+ D + R 
Sbjct: 228 MKVLMLTLQNDPPSLETGVQDKEMLKKYGK------------SFRKMISLCLQKDPEKRP 275

Query: 314 TAREAMEHPYFY 325
           TA E + H +F 
Sbjct: 276 TAAELLRHKFFQ 287


>6HXF-B nrPDB
          Length = 302

 Score =  236 bits (602), Expect = 1e-62,   Method: Composition-based stats.
 Identities = 75/320 (23%), Positives = 142/320 (44%), Gaps = 51/320 (15%)

Query: 25  DYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKR---E 81
           +YE    +    + +++V +LG G + +V++A N         K+++   +++++    E
Sbjct: 7   EYEHVRRDLDPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVE 66

Query: 82  IKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNT----DFKQLYQTLTDYDIRFYM 137
           I+IL      P I+ L             ++ E            +L + LT+  I+   
Sbjct: 67  IEILATC-DHPYIVKLLGAYYH--DGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVC 123

Query: 138 YEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGL-AEFYHPGQEYNVRVASRY 196
            ++L+AL++ HS  I+HRD+K  NV++  E   +RL D+G+ A+     Q+ +  + + Y
Sbjct: 124 RQMLEALNFLHSKRIIHRDLKAGNVLMTLEG-DIRLADFGVSAKNLKTLQKRDSFIGTPY 182

Query: 197 FKGPELL----VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTE 252
           +  PE++    +    YDY  D+WSLG  L  M  + EP  H  +    L++IAK     
Sbjct: 183 WMAPEVVMCETMKDTPYDYKADIWSLGITLIEMA-QIEPPHHELNPMRVLLKIAK----- 236

Query: 253 DLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSR 312
                            +D     +  +W            S E  DFL   L  + ++R
Sbjct: 237 -----------------SDPPTLLTPSKW------------SVEFRDFLKIALDKNPETR 267

Query: 313 LTAREAMEHPYFYTVVKDQA 332
            +A + +EHP+  ++  ++A
Sbjct: 268 PSAAQLLEHPFVSSITSNKA 287


>4AW2-A nrPDB
          Length = 437

 Score =  235 bits (600), Expect = 2e-62,   Method: Composition-based stats.
 Identities = 76/352 (21%), Positives = 137/352 (38%), Gaps = 58/352 (16%)

Query: 35  NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL------KPVKKKKIKREIKILENL 88
           +++D+++++ +GRG + EV        ++   +KIL      K  +    + E  +L N 
Sbjct: 72  HREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVN- 130

Query: 89  RGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----LTDYDIRFYMYEILKAL 144
                I TL    +D       LV ++    D   L       L +   RFY+ E++ A+
Sbjct: 131 GDSKWITTLHYAFQD--DNNLYLVMDYYVGGDLLTLLSKFEDRLPEEMARFYLAEMVIAI 188

Query: 145 DYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQ-EYNVRVASRYFKGPEL 202
           D  H +  +HRD+KP N+++D  +  +RL D+G   +    G  + +V V +  +  PE+
Sbjct: 189 DSVHQLHYVHRDIKPDNILMDM-NGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEI 247

Query: 203 LV----DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYI 258
           L         Y    D WSLG  +  M++ + PF+      +   +I             
Sbjct: 248 LQAMEGGKGRYGPECDWWSLGVCMYEMLYGETPFY-AESLVETYGKIMN----------- 295

Query: 259 DKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRL---TA 315
                                  ERF        VS  A D + +L+    + RL     
Sbjct: 296 ---------------------HKERFQFPTQVTDVSENAKDLIRRLIC-SREHRLGQNGI 333

Query: 316 REAMEHPYFYTVVKDQARMG-SSSMPGGSTPVSSANMMSGISSVPTPSPLGP 366
            +  +HP+F  +  D  R   +  +P  S+P  ++N       +     + P
Sbjct: 334 EDFKKHPFFSGIDWDNIRNCEAPYIPEVSSPTDTSNFDVDDDCLKNSETMPP 385


>3TKU-A nrPDB
          Length = 433

 Score =  235 bits (600), Expect = 2e-62,   Method: Composition-based stats.
 Identities = 75/352 (21%), Positives = 135/352 (38%), Gaps = 58/352 (16%)

Query: 35  NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL------KPVKKKKIKREIKILENL 88
           +++D+++++ +GRG + EV             +KIL      K  +    + E  +L N 
Sbjct: 88  HREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVN- 146

Query: 89  RGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----LTDYDIRFYMYEILKAL 144
                I  L    +D       LV ++    D   L       L +   RFY+ E++ A+
Sbjct: 147 GDCQWITALHYAFQD--ENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAI 204

Query: 145 DYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ--EYNVRVASRYFKGPEL 202
           D  H +  +HRD+KP NV++D  +  +RL D+G     +     + +V V +  +  PE+
Sbjct: 205 DSIHQLHYVHRDIKPDNVLLDV-NGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEI 263

Query: 203 LV----DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYI 258
           L         Y    D WSLG  +  M++ + PF+      +   +I             
Sbjct: 264 LQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFY-AESLVETYGKIMNHE--------- 313

Query: 259 DKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRL---TA 315
                                  ERF    +   VS EA D + +L+    + RL     
Sbjct: 314 -----------------------ERFQFPSHVTDVSEEAKDLIQRLIC-SRERRLGQNGI 349

Query: 316 REAMEHPYFYTVVKDQAR-MGSSSMPGGSTPVSSANMMSGISSVPTPSPLGP 366
            +  +H +F  +  +  R + +  +P  S+P  ++N       +     L P
Sbjct: 350 EDFKKHAFFEGLNWENIRNLEAPYIPDVSSPSDTSNFDVDDDVLRNTEILPP 401


>6FYV-A nrPDB
          Length = 337

 Score =  235 bits (599), Expect = 3e-62,   Method: Composition-based stats.
 Identities = 72/331 (21%), Positives = 150/331 (45%), Gaps = 43/331 (12%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINIT-NNEKVVVKILKPV--KKKKIKREIKILENLRG-G 91
           +  Y++V  LG G + +V E I+   +   V VKI+K V   ++  + EI++LE+L    
Sbjct: 13  RARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTD 72

Query: 92  PN----IITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ----TLTDYDIRFYMYEILKA 143
           PN     + + +           +VFE +  + +  + +          IR   Y+I ++
Sbjct: 73  PNSVFRCVQMLEWFDH--HGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQS 130

Query: 144 LDYCHSMGIMHRDVKPHNVMI------------------DHEHRKLRLIDWGLAEFYHPG 185
           +++ H   + H D+KP N++                     ++  ++++D+G A +    
Sbjct: 131 INFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATY--DD 188

Query: 186 QEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRI 245
           + ++  V++R+++ PE+++    +    D+WS+GC+L         F   HD+ + L  +
Sbjct: 189 EHHSTLVSTRHYRAPEVILAL-GWSQPCDVWSIGCILIEYYLGFTVF-QTHDSKEHLAMM 246

Query: 246 AKVLGTEDLYDYIDK------YNIELDPRFNDILGRHSRKRWERFVHSENQH-LVSPEAL 298
            ++LG    +           ++ +LD   +   GR+ R+R +        H     +  
Sbjct: 247 ERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLF 306

Query: 299 DFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 329
           D + ++L YD   R+T  EA++HP+F  + K
Sbjct: 307 DLVRRMLEYDPTQRITLDEALQHPFFDLLKK 337


>3ORZ-A nrPDB
          Length = 316

 Score =  235 bits (599), Expect = 3e-62,   Method: Composition-based stats.
 Identities = 72/319 (22%), Positives = 128/319 (40%), Gaps = 61/319 (19%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKI------LKPVKKKKIKREIKILENLRG 90
           +D++  + LG G +S V  A  +  + +  +KI      +K  K   + RE  ++  L  
Sbjct: 37  EDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRL-D 95

Query: 91  GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYC 147
            P  + L    +D           +  N +  +  +      +   RFY  EI+ AL+Y 
Sbjct: 96  HPFFVKLYFCFQD--DEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYL 153

Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE---YNVRVASRYFKGPELLV 204
           H  GI+HRD+KP N++++ E   +++ D+G A+   P  +    N  V +  +  PELL 
Sbjct: 154 HGKGIIHRDLKPENILLN-EDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLT 212

Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIE 264
           +      S D+W+LGC++  ++    PF  G++                ++  I K   +
Sbjct: 213 EKSAC-KSSDLWALGCIIYQLVAGLPPFRAGNEYL--------------IFQKIIKLEYD 257

Query: 265 LDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTARE------A 318
              +F                         P+A D ++KLL  D   RL   E       
Sbjct: 258 FPEKF------------------------FPKARDLVEKLLVLDATKRLGCEEMEGYGPL 293

Query: 319 MEHPYFYTVVKDQARMGSS 337
             HP+F +V  +     + 
Sbjct: 294 KAHPFFESVTWENLHQQTP 312


>6AO5-A nrPDB
          Length = 362

 Score =  235 bits (599), Expect = 3e-62,   Method: Composition-based stats.
 Identities = 63/302 (20%), Positives = 120/302 (39%), Gaps = 46/302 (15%)

Query: 31  VEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPV-KKKKIKREIKILENLR 89
           +    ++ + ++ KLG G Y  VF+AI+  + + V +K +      ++I +EI I++   
Sbjct: 4   LTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQC- 62

Query: 90  GGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ----TLTDYDIRFYMYEILKALD 145
             P ++               +V E+        + +    TL + +I   +   LK L+
Sbjct: 63  DSPYVVKYYGSYFKNTD--LWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLE 120

Query: 146 YCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLV 204
           Y H M  +HR++K  N++++ E    +L D+G+A +      + N  + + ++  PE++ 
Sbjct: 121 YLHFMRKIHRNIKAGNILLNTEGHA-KLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQ 179

Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIE 264
           +   Y+   D+WSLG     M   K P+   H                     I      
Sbjct: 180 EI-GYNCVADIWSLGITSIEMAEGKPPYADIH-----------------PMRAIFMIPTN 221

Query: 265 LDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324
             P F                      L S +  DF+ K L  + + R TA + ++HP+ 
Sbjct: 222 PPPTFR------------------KPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFI 263

Query: 325 YT 326
             
Sbjct: 264 KN 265


>3LM0-A nrPDB
          Length = 327

 Score =  233 bits (594), Expect = 1e-61,   Method: Composition-based stats.
 Identities = 66/350 (18%), Positives = 140/350 (40%), Gaps = 54/350 (15%)

Query: 25  DYESHVVEWGNQDDYQLV-----RKLGRGKYSEVFEAINITNNEKVVVKILKPVKK---- 75
           D  +  + + + +++        ++LGRGK++ V + I+ +  ++   K LK  ++    
Sbjct: 12  DLGTENLYFQSMENFNNFYILTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDC 71

Query: 76  -KKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTD-----FKQLYQTLT 129
             +I  EI +LE  +  P +I L ++ ++       L+ E+    +       +L + ++
Sbjct: 72  RAEILHEIAVLELAKSCPRVINLHEVYENTSE--IILILEYAAGGEIFSLCLPELAEMVS 129

Query: 130 DYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDH--EHRKLRLIDWGLAEFYHPGQE 187
           + D+   + +IL+ + Y H   I+H D+KP N+++        ++++D+G++       E
Sbjct: 130 ENDVIRLIKQILEGVYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACE 189

Query: 188 YNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAK 247
               + +  +  PE+L +Y     + DMW++G +   ++    PF  G DN +  + I++
Sbjct: 190 LREIMGTPEYLAPEIL-NYDPITTATDMWNIGIIAYMLLTHTSPFV-GEDNQETYLNISQ 247

Query: 248 VLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRY 307
           V                                       E    VS  A DF+  LL  
Sbjct: 248 V---------------------------------NVDYSEETFSSVSQLATDFIQSLLVK 274

Query: 308 DHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISS 357
           + + R TA   + H +      +       +     T   S       +S
Sbjct: 275 NPEKRPTAEICLSHSWLQQWDFENLFHPEETSSSSQTQDHSVRSSEDKTS 324


>5YV8-A nrPDB
          Length = 298

 Score =  232 bits (593), Expect = 1e-61,   Method: Composition-based stats.
 Identities = 65/321 (20%), Positives = 132/321 (41%), Gaps = 72/321 (22%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK--------------------- 75
           + Y L  ++G+G Y  V  A N  +N    +K+L   K                      
Sbjct: 13  NQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGG 72

Query: 76  --------KKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQL--Y 125
                   +++ +EI IL+ L   PN++ L +++ DP      +VFE VN     ++   
Sbjct: 73  CIQPRGPIEQVYQEIAILKKL-DHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTL 131

Query: 126 QTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH-P 184
           + L++   RFY  +++K ++Y H   I+HRD+KP N+++  +   +++ D+G++  +   
Sbjct: 132 KPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGH-IKIADFGVSNEFKGS 190

Query: 185 GQEYNVRVASRYFKGPELLVDYQMY--DYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQL 242
               +  V +  F  PE L + +      +LD+W++G  L   +F + PF          
Sbjct: 191 DALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMD-------- 242

Query: 243 VRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLD 302
               +++                             K   + +   +Q  ++ +  D + 
Sbjct: 243 ---ERIMC-------------------------LHSKIKSQALEFPDQPDIAEDLKDLIT 274

Query: 303 KLLRYDHQSRLTAREAMEHPY 323
           ++L  + +SR+   E   HP+
Sbjct: 275 RMLDKNPESRIVVPEIKLHPW 295


>5J5T-A nrPDB
          Length = 370

 Score =  232 bits (592), Expect = 2e-61,   Method: Composition-based stats.
 Identities = 60/299 (20%), Positives = 124/299 (41%), Gaps = 46/299 (15%)

Query: 34  GNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKI---KREIKILENLRG 90
           G+Q+D++L++++G G Y +V++A N+   E   +K++K    +     ++EI ++++ + 
Sbjct: 1   GSQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKH 60

Query: 91  GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ---TLTDYDIRFYMYEILKALDYC 147
            PNI+               +  E       + +Y     L++  I +   E L+ L Y 
Sbjct: 61  -PNIVAYFGSY--LRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYL 117

Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGL-AEFYHPGQEYNVRVASRYFKGPEL--LV 204
           HS G MHRD+K  N+++  ++  ++L D+G+ A+      +    + + Y+  PE+  + 
Sbjct: 118 HSKGKMHRDIKGANILLT-DNGHVKLADFGVSAQITATIAKRKAFIGTPYWMAPEVAAVE 176

Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIE 264
               Y+   D+W++G     +   + P F  H      +          L D +      
Sbjct: 177 RKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKM------ 230

Query: 265 LDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323
                          +W    H             F+   L  + + R TA + ++HP+
Sbjct: 231 ---------------KWSNSFH------------HFVKMALTKNPKKRPTAEKLLQHPF 262


>3NYO-A nrPDB
          Length = 576

 Score =  232 bits (592), Expect = 2e-61,   Method: Composition-based stats.
 Identities = 79/339 (23%), Positives = 132/339 (38%), Gaps = 55/339 (16%)

Query: 23  YWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK------KK 76
           +  ++    +   ++ ++  R LG+G + EV         +    K L+  +      + 
Sbjct: 170 FLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEA 229

Query: 77  KIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY-----QTLTDY 131
               E +ILE +     +++LA   +        LV   +N  D K            + 
Sbjct: 230 MALNEKQILEKV-NSRFVVSLAYAYE--TKDALCLVLTLMNGGDLKFHIYHMGQAGFPEA 286

Query: 132 DIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVR 191
              FY  EI   L+  H   I++RD+KP N+++D +H  +R+ D GLA     GQ    R
Sbjct: 287 RAVFYAAEICCGLEDLHRERIVYRDLKPENILLD-DHGHIRISDLGLAVHVPEGQTIKGR 345

Query: 192 VASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGT 251
           V +  +  PE++ + + Y +S D W+LGC+L  MI  + PF           +  K +  
Sbjct: 346 VGTVGYMAPEVVKNER-YTFSPDWWALGCLLYEMIAGQSPF----------QQRKKKIKR 394

Query: 252 EDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQS 311
           E++   + +   E   RF                        SP+A     +LL  D   
Sbjct: 395 EEVERLVKEVPEEYSERF------------------------SPQARSLCSQLLCKDPAE 430

Query: 312 RL-----TAREAMEHPYFYTVVKDQARMGSSSMPGGSTP 345
           RL     +ARE  EHP F  +   +   G    P    P
Sbjct: 431 RLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDP 469


>4TNB-A nrPDB
          Length = 590

 Score =  232 bits (592), Expect = 2e-61,   Method: Composition-based stats.
 Identities = 79/339 (23%), Positives = 126/339 (37%), Gaps = 55/339 (16%)

Query: 23  YWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK----- 77
           +  ++    +   ++ ++  R LG+G + EV         +    K L+  + KK     
Sbjct: 170 FLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGES 229

Query: 78  -IKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY-----QTLTDY 131
               E +ILE +     ++ LA   +        LV   +N  D K            + 
Sbjct: 230 MALNEKQILEKV-NSQFVVNLAYAYE--TKDALCLVLTIMNGGDLKFHIYNMGNPGFEEE 286

Query: 132 DIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVR 191
              FY  EIL  L+  H    ++RD+KP N+++D ++  +R+ D GLA     G     R
Sbjct: 287 RALFYAAEILCGLEDLHHENTVYRDLKPENILLD-DYGHIRISDLGLAVKIPEGDLIRGR 345

Query: 192 VASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGT 251
           V +  +  PE+L + Q Y  S D W LGC++  MI  + PF    +   +     +VL T
Sbjct: 346 VGTVGYMAPEVL-NNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLET 404

Query: 252 EDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQS 311
           E++Y                                   H  S EA      LL  D + 
Sbjct: 405 EEVY----------------------------------SHKFSEEAKSICKMLLTKDAKQ 430

Query: 312 RLT-----AREAMEHPYFYTVVKDQARMGSSSMPGGSTP 345
           RL      A E   HP+F  +   +   G    P    P
Sbjct: 431 RLGCQEEEAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDP 469


>4I6B-A nrPDB
          Length = 308

 Score =  232 bits (591), Expect = 2e-61,   Method: Composition-based stats.
 Identities = 61/307 (19%), Positives = 128/307 (41%), Gaps = 53/307 (17%)

Query: 30  VVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL------KPVKKKKIKREIK 83
           +V+      Y   + LG+G +++ +E  ++TNN+    KI+      KP +++KI +EI+
Sbjct: 21  IVDPTTGKRYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKIDKEIE 80

Query: 84  ILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEI 140
           +   L    +++      +D       ++ E+ +      + +    LT+ ++R+Y+ +I
Sbjct: 81  LHRIL-HHKHVVQFYHYFEDK--ENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQI 137

Query: 141 LKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHP-GQEYNVRVASRYFKG 199
           +  L Y H   I+HRD+K  N  I+ E  +L++ D+GLA    P          +  +  
Sbjct: 138 VSGLKYLHEQEILHRDLKLGNFFIN-ESMELKVGDFGLAARLEPLEHRRRTICGTPNYLS 196

Query: 200 PELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYID 259
           PE+L + Q +    D+W+LGC++ +M+  + PF              +    ++ Y  I 
Sbjct: 197 PEVL-NKQGHGAESDIWALGCVMYTMLLGRPPF--------------ETTNLKETYRSIR 241

Query: 260 KYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAM 319
           +    +                               A   +  +L  + + R +  + +
Sbjct: 242 EARYTMPSSLL------------------------APAKHLIASMLSKNPEDRPSLDDII 277

Query: 320 EHPYFYT 326
            H +F  
Sbjct: 278 RHDFFTQ 284


>4KS7-A nrPDB
          Length = 292

 Score =  232 bits (591), Expect = 3e-61,   Method: Composition-based stats.
 Identities = 63/287 (21%), Positives = 123/287 (42%), Gaps = 46/287 (16%)

Query: 44  KLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK---IKREIKILENLRGGPNIITLADI 100
           K+G G    V  A    +  +V VK++   K+++   +  E+ I+ + +   N++ +   
Sbjct: 30  KIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHF-NVVEMYKS 88

Query: 101 VKDPVSRTPALVFEHVNNTDFKQLYQ--TLTDYDIRFYMYEILKALDYCHSMGIMHRDVK 158
               V     ++ E +       +     L +  I      +L+AL Y H+ G++HRD+K
Sbjct: 89  Y--LVGEELWVLMEFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIK 146

Query: 159 PHNVMIDHEHRKLRLIDWGL-AEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWS 217
             ++++  + R ++L D+G  A+      +    V + Y+  PE++    +Y   +D+WS
Sbjct: 147 SDSILLTLDGR-VKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVI-SRSLYATEVDIWS 204

Query: 218 LGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHS 277
           LG M+  M+  + P+F                 ++     + +      P+         
Sbjct: 205 LGIMVIEMVDGEPPYF-----------------SDSPVQAMKRLRDSPPPKLK------- 240

Query: 278 RKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324
                      N H VSP   DFL+++L  D Q R TA+E ++HP+ 
Sbjct: 241 -----------NSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFL 276


>3Q53-A nrPDB
          Length = 306

 Score =  231 bits (590), Expect = 3e-61,   Method: Composition-based stats.
 Identities = 65/294 (22%), Positives = 127/294 (43%), Gaps = 46/294 (15%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPV---KKKKIKREIKILENLRGGPNI 94
            Y    K+G+G    V+ A+++   ++V ++ +      KK+ I  EI ++   +  PNI
Sbjct: 22  KYTRFEKIGQGASGTVYTAMDVATGQEVAIRQMNLQQQPKKELIINEILVMRENKN-PNI 80

Query: 95  ITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ--TLTDYDIRFYMYEILKALDYCHSMGI 152
           +   D     V     +V E++       +     + +  I     E L+AL++ HS  +
Sbjct: 81  VNYLDSY--LVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQV 138

Query: 153 MHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ-EYNVRVASRYFKGPELLVDYQMYDY 211
           +HRD+K  N+++  +   ++L D+G      P Q + +  V + Y+  PE++   + Y  
Sbjct: 139 IHRDIKSDNILLGMDG-SVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVV-TRKAYGP 196

Query: 212 SLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFND 271
            +D+WSLG M   MI  + P+   ++N  + + +    GT +L                 
Sbjct: 197 KVDIWSLGIMAIEMIEGEPPYL--NENPLRALYLIATNGTPEL----------------- 237

Query: 272 ILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFY 325
                           +N   +S    DFL++ L  D + R +A+E ++H +  
Sbjct: 238 ----------------QNPEKLSAIFRDFLNRCLEMDVEKRGSAKELIQHQFLK 275


>4YNZ-A nrPDB
          Length = 342

 Score =  231 bits (590), Expect = 3e-61,   Method: Composition-based stats.
 Identities = 79/333 (23%), Positives = 137/333 (41%), Gaps = 59/333 (17%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK-----KIKREIKILENLRGGPN 93
           Y+L + LG+G+   V   I+    +KV +KI+   K       K++REI IL+ L   P+
Sbjct: 12  YRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSESVLMKVEREIAILK-LIEHPH 70

Query: 94  IITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCHSM 150
           ++ L D+ ++   +   LV EHV+  +          LT  + R +  +I+ ALD+CHS 
Sbjct: 71  VLKLHDVYENK--KYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSH 128

Query: 151 GIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYD 210
            I HRD+KP N+++D E   +R+ D+G+A              S ++  PE++   +   
Sbjct: 129 SICHRDLKPENLLLD-ERNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDG 187

Query: 211 YSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFN 270
              D+WS G +L +++    PF    DN  QL+                K  +   P F 
Sbjct: 188 RKADVWSCGVILFALLVGALPF--DDDNLRQLLEKV-------------KRGVFHMPHF- 231

Query: 271 DILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKD 330
                                 + P+    L  ++  D   RLT     +H ++      
Sbjct: 232 ----------------------IPPDCQSLLRGMIEVDAARRLTLEHIQKHIWY------ 263

Query: 331 QARMGSSSMPGGSTPVSSANMMSGISSVPTPSP 363
              +G  + P    P+     +  + S+    P
Sbjct: 264 ---IGGKNEPEPEQPIPRKVQIRSLPSLEDIDP 293


>6BDL-A nrPDB
          Length = 347

 Score =  231 bits (589), Expect = 4e-61,   Method: Composition-based stats.
 Identities = 71/344 (20%), Positives = 141/344 (40%), Gaps = 59/344 (17%)

Query: 38  DYQLVRKLGRGKYSEVFEAINI-TNNEKVVVKILKP------VKKKKIKREIKILENLRG 90
           D+ ++  LG G +  V         ++   +KILK        +++ I+ E +I++    
Sbjct: 35  DFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQG-AH 93

Query: 91  GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ---TLTDYDIRFYMYEILKALDYC 147
              I+ L    KD  S+   ++ E     +   + +   +  D   RFY   +++A  Y 
Sbjct: 94  SDFIVRLYRTFKD--SKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYL 151

Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQ 207
           HS GI++RD+KP N+++DH     +L+D+G A+    G++      +  +  PE++++ +
Sbjct: 152 HSKGIIYRDLKPENLILDHRGYA-KLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILN-K 209

Query: 208 MYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDP 267
            +D S D WSLG ++  ++    PF  G D       I + +   D+ ++  K       
Sbjct: 210 GHDISADYWSLGILMYELLTGSPPF-SGPDPMKTYNIILRGI---DMIEFPKK------- 258

Query: 268 RFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRL-----TAREAMEHP 322
                                    ++  A + + KL R +   RL       ++  +H 
Sbjct: 259 -------------------------IAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHK 293

Query: 323 YFYTVVKDQAR---MGSSSMPGGSTPVSSANMMSGISSVPTPSP 363
           +F     +  R   +    +P  ++P  ++N  S       P P
Sbjct: 294 WFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNDEPPP 337


>2F57-A nrPDB
          Length = 317

 Score =  230 bits (587), Expect = 6e-61,   Method: Composition-based stats.
 Identities = 64/288 (22%), Positives = 118/288 (40%), Gaps = 46/288 (15%)

Query: 44  KLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK---IKREIKILENLRGGPNIITLADI 100
           K+G G    V  A      ++V VK +   K+++   +  E+ I+ +     N++ +   
Sbjct: 52  KIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRD-YHHDNVVDMYSS 110

Query: 101 VKDPVSRTPALVFEHVNNTDFKQL--YQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVK 158
               V     +V E +       +  +  + +  I      +L+AL Y H+ G++HRD+K
Sbjct: 111 Y--LVGDELWVVMEFLEGGALTDIVTHTRMNEEQIATVCLSVLRALSYLHNQGVIHRDIK 168

Query: 159 PHNVMIDHEHRKLRLIDWGL-AEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWS 217
             ++++  + R ++L D+G  A+      +    V + Y+  PE++     Y   +D+WS
Sbjct: 169 SDSILLTSDGR-IKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRL-PYGTEVDIWS 226

Query: 218 LGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHS 277
           LG M+  MI  + P+F+                 E     + +    L PR  D+     
Sbjct: 227 LGIMVIEMIDGEPPYFN-----------------EPPLQAMRRIRDSLPPRVKDL----- 264

Query: 278 RKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFY 325
                        H VS     FLD +L  +   R TA+E + HP+  
Sbjct: 265 -------------HKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLK 299


>5LOH-A nrPDB
          Length = 341

 Score =  230 bits (587), Expect = 7e-61,   Method: Composition-based stats.
 Identities = 71/331 (21%), Positives = 126/331 (38%), Gaps = 60/331 (18%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK------KKKIKREIKILENLRG 90
           +++ +V+ + RG + +V+        +   VK++K           +++ E   L  L  
Sbjct: 36  EEFSIVKPISRGAFGKVYLGQ--KGGKLYAVKVVKKADMINKNMTHQVQAERDALA-LSK 92

Query: 91  GPNIITLADIVKDPVSRTPALVFEHVNNTD---FKQLYQTLTDYDIRFYMYEILKALDYC 147
            P I+ L   ++   +    LV E++   D      +Y    +     Y+ E+  ALDY 
Sbjct: 93  SPFIVHLYYSLQS--ANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALALDYL 150

Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF-------YHPGQEYNVRVASRYFKGP 200
           H  GI+HRD+KP N++I +E   ++L D+GL++                    +  +  P
Sbjct: 151 HRHGIIHRDLKPDNMLISNEGH-IKLTDFGLSKVTLNRDINMMDILTTRTFCGTPDYLAP 209

Query: 201 ELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDK 260
           ELL+  + +  ++D W+LG  L   +    PF    +   Q+                  
Sbjct: 210 ELLLG-RAHGPAVDWWALGVCLFEFLTGIPPF--NDETPQQV------------------ 248

Query: 261 YNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAME 320
                   F +IL R            E +  +S  A   ++ LL  D   R   +E   
Sbjct: 249 --------FQNILKRD-------IPWPEGEEKLSDNAQSAVEILLTIDDTKRAGMKELKR 293

Query: 321 HPYFYTVVKDQARMGSSSMPGGSTPVSSANM 351
           HP F  V  D   +   +MP    P    + 
Sbjct: 294 HPLFSDV--DWENLQHQTMPFIPQPDDETDT 322


>3DB8-A nrPDB
          Length = 317

 Score =  230 bits (586), Expect = 8e-61,   Method: Composition-based stats.
 Identities = 67/342 (19%), Positives = 143/342 (41%), Gaps = 62/342 (18%)

Query: 3   GPVPSRARVYTDVNTHRPREYWDYESH--------VVEWGNQDDYQLVRKLGRGKYSEVF 54
           GP+ S +       + +P  + D +S         +V+      Y   R LG+G +++ +
Sbjct: 1   GPLGSMSA-AIAKPSAKPSAHVDPKSAPLKEIPDVLVDPRTMKRYMRGRFLGKGGFAKCY 59

Query: 55  EAINITNNEKVVVKI------LKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRT 108
           E  ++   E    K+      LKP +K+K+  EI I ++L   P+++      +D     
Sbjct: 60  EITDMDTKEVFAGKVVPKSMLLKPHQKEKMSTEIAIHKSLDN-PHVVGFHGFFED--DDF 116

Query: 109 PALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMID 165
             +V E        +L++    +T+ + R++M + ++ + Y H+  ++HRD+K  N+ ++
Sbjct: 117 VYVVLEICRRRSLLELHKRRKAVTEPEARYFMRQTIQGVQYLHNNRVIHRDLKLGNLFLN 176

Query: 166 HEHRKLRLIDWGLAEFYH-PGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLAS 224
            +   +++ D+GLA      G+       +  +  PE+L   + + + +D+WSLGC+L +
Sbjct: 177 -DDMDVKIGDFGLATKIEFDGERKKDLCGTPNYIAPEVLCK-KGHSFEVDIWSLGCILYT 234

Query: 225 MIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERF 284
           ++  K PF              +    ++ Y  I K    +                   
Sbjct: 235 LLVGKPPF--------------ETSCLKETYIRIKKNEYSVP------------------ 262

Query: 285 VHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYT 326
                   ++P A   + ++L  D   R +  E +   +F +
Sbjct: 263 ------RHINPVASALIRRMLHADPTLRPSVAELLTDEFFTS 298


>4B6L-A nrPDB
          Length = 281

 Score =  230 bits (586), Expect = 1e-60,   Method: Composition-based stats.
 Identities = 69/309 (22%), Positives = 128/309 (41%), Gaps = 54/309 (17%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKIL------KPVKKKKIKREIKILENLRGGP 92
           Y   R LG+G ++  +EA +        VK++      KP +++KI  EI++  +L+   
Sbjct: 11  YLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQH-R 69

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ---TLTDYDIRFYMYEILKALDYCHS 149
           +I+  +   +D  +    +  E  +      +++   TL + ++R+Y+ +IL  L Y H 
Sbjct: 70  HIVRFSHHFED--ADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQ 127

Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGL-AEFYHPGQEYNVRVASRYFKGPELLVDYQM 208
            GI+HRD+K  N  I  E+ +L++ D+GL A    P Q       +  +  PE+L+  Q 
Sbjct: 128 RGILHRDLKLGNFFIT-ENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLL-RQG 185

Query: 209 YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPR 268
           +    D+WSLGC++ +++    PF                                    
Sbjct: 186 HGPEADVWSLGCVMYTLLCGSPPF------------------------------------ 209

Query: 269 FNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF-YTV 327
             +        R  + VH      +S  A   L  +LR   + R +  + + H +F    
Sbjct: 210 --ETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPSIDQILRHDFFTKGY 267

Query: 328 VKDQARMGS 336
             D+  + S
Sbjct: 268 TPDRLPISS 276


>3RAW-A nrPDB
          Length = 381

 Score =  230 bits (586), Expect = 1e-60,   Method: Composition-based stats.
 Identities = 78/348 (22%), Positives = 155/348 (44%), Gaps = 48/348 (13%)

Query: 25  DYESHVV----EWGNQDDYQLVRKLGRGKYSEVFEAINITNNE-KVVVKILKPV--KKKK 77
           D E H+V    +W  Q+ Y++V  LG G + +V E ++    + +V +KI++ V   ++ 
Sbjct: 36  DKEGHLVCRIGDW-LQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREA 94

Query: 78  IKREIKILENLR--GGPN---IITLADIVKDPVSRTPALVFEHVNNTDFKQL----YQTL 128
            + EI +L+ ++     N    + ++D           + FE +    F+ L    +Q  
Sbjct: 95  ARLEINVLKKIKEKDKENKFLCVLMSDWF--NFHGHMCIAFELLGKNTFEFLKENNFQPY 152

Query: 129 TDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMI------------------DHEHRK 170
               +R   Y++  AL + H   + H D+KP N++                     ++  
Sbjct: 153 PLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTS 212

Query: 171 LRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKE 230
           +R+ D+G A F    + +   VA+R+++ PE++++   +    D+WS+GC+L    +R  
Sbjct: 213 IRVADFGSATF--DHEHHTTIVATRHYRPPEVILEL-GWAQPCDVWSIGCILFEY-YRGF 268

Query: 231 PFFHGHDNYDQLVRIAKVLGTEDLYDYIDK------YNIELDPRFNDILGRHSRKRWERF 284
             F  H+N + LV + K+LG    +           Y   L    N   GR+ ++  +  
Sbjct: 269 TLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPL 328

Query: 285 VHSENQHLV-SPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQ 331
                Q  +   +  D + ++L +D   R+T  EA+ HP+F  +  ++
Sbjct: 329 KSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEE 376


>3PFQ-A nrPDB
          Length = 674

 Score =  229 bits (585), Expect = 1e-60,   Method: Composition-based stats.
 Identities = 76/358 (21%), Positives = 124/358 (34%), Gaps = 66/358 (18%)

Query: 34  GNQD-----DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPV------KKKKIKREI 82
           GN+D     D+  +  LG+G + +V  +     +E   VKILK          +    E 
Sbjct: 333 GNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEK 392

Query: 83  KILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ---TLTDYDIRFYMYE 139
           ++L      P +  L    +         V E+VN  D     Q      +    FY  E
Sbjct: 393 RVLALPGKPPFLTQLHSCFQ--TMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAE 450

Query: 140 ILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF-YHPGQEYNVRVASRYFK 198
           I   L +  S GI++RD+K  NVM+D E   +++ D+G+ +     G        +  + 
Sbjct: 451 IAIGLFFLQSKGIIYRDLKLDNVMLDSEGH-IKIADFGMCKENIWDGVTTKTFCGTPDYI 509

Query: 199 GPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYI 258
            PE++  YQ Y  S+D W+ G +L  M+  + PF  G D  +    I +           
Sbjct: 510 APEIIA-YQPYGKSVDWWAFGVLLYEMLAGQAPF-EGEDEDELFQSIME----------- 556

Query: 259 DKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTA--- 315
                                      +      +S EA+     L+      RL     
Sbjct: 557 --------------------------HNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPE 590

Query: 316 --REAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLGPLAGSP 371
             R+  EH +F  +  ++        P    P +S           T  P  P+   P
Sbjct: 591 GERDIKEHAFFRYIDWEKLERKEIQPP--YKPKASGRNAENFDRFFTRHP--PVLTPP 644


>5DYK-A nrPDB
          Length = 853

 Score =  229 bits (584), Expect = 1e-60,   Method: Composition-based stats.
 Identities = 71/335 (21%), Positives = 135/335 (40%), Gaps = 56/335 (16%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVK------ILKPVKKKKIKREIKILENLR 89
            D+ +  R +GRG +  V    +     +  +K      I+   ++  IK E +I     
Sbjct: 538 MDELETERIIGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINLNQQNNIKLEREITAE-N 596

Query: 90  GGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTL---TDYDIRFYMYEILKALDY 146
             P II L    KD  S+    + E V   +     + L   +    +FY+  I+ A++Y
Sbjct: 597 DHPFIIRLVRTFKD--SKYFYFLTELVTGGELYDAIRKLGLLSKSQAQFYLGSIILAIEY 654

Query: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDY 206
            H   I++RD+KP N+++D +   ++LID+G A+    G+ Y   V + ++  PE+++  
Sbjct: 655 LHERNIVYRDLKPENILLDKQGY-VKLIDFGCAKKVQ-GRAYT-LVGTPHYMAPEVILG- 710

Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 266
           + Y  ++D+W+LG  L   I    PF  G+D  DQL     +L  +  +           
Sbjct: 711 KGYGCTVDIWALGICLYEFICGPLPF--GNDEEDQLEIFRDILTGQLTFP---------- 758

Query: 267 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTA-----REAMEH 321
                                   ++   ++++ + +LL    Q R+       ++  +H
Sbjct: 759 -----------------------DYVTDTDSINLMKRLLCRLPQGRIGCSINGFKDIKDH 795

Query: 322 PYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGIS 356
           P+F     D+        P  S   + A  +    
Sbjct: 796 PFFSNFNWDKLAGRLLDPPLVSKSETYAEDIDIKQ 830


>6E9W-A nrPDB
          Length = 443

 Score =  229 bits (584), Expect = 2e-60,   Method: Composition-based stats.
 Identities = 73/353 (20%), Positives = 128/353 (36%), Gaps = 64/353 (18%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVK------ILKPVKKKKIKREIKILENLRG 90
           +DY++V+ +GRG + EV    + +  +   +K      ++K         E  I+     
Sbjct: 102 EDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMA-FAN 160

Query: 91  GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTL--TDYDIRFYMYEILKALDYCH 148
            P ++ L    +D   R   +V E++   D   L       +   RFY  E++ ALD  H
Sbjct: 161 SPWVVQLFYAFQD--DRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDAIH 218

Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHP--GQEYNVRVASRYFKGPELLV-- 204
           SMG +HRDVKP N+++D     L+L D+G     +       +  V +  +  PE+L   
Sbjct: 219 SMGFIHRDVKPDNMLLDKSGH-LKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQ 277

Query: 205 -DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNI 263
                Y    D WS+G  L  M+    PF+              ++GT            
Sbjct: 278 GGDGYYGRECDWWSVGVFLYEMLVGDTPFYADS-----------LVGTYSKIMNH----- 321

Query: 264 ELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRL---TAREAME 320
                             +  +   + + +S EA + +   L  D + RL      E   
Sbjct: 322 ------------------KNSLTFPDDNDISKEAKNLICAFLT-DREVRLGRNGVEEIKR 362

Query: 321 HPYFYTVVKDQARMG---SSSMPGGSTPVSSANMMS------GISSVPTPSPL 364
           H +F         +    +  +P  S+ + ++N            + P P   
Sbjct: 363 HLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEEDKGEEETFPIPKAF 415


>5DBX-A nrPDB
          Length = 328

 Score =  228 bits (582), Expect = 3e-60,   Method: Composition-based stats.
 Identities = 62/353 (17%), Positives = 126/353 (35%), Gaps = 56/353 (15%)

Query: 28  SHVVEWGN-QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK----KIKREI 82
           +  V W   +D Y+L   +G G  + V  A+     E+V +K +   K +    ++ +EI
Sbjct: 1   AQAVGWPICRDAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEI 60

Query: 83  KILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ-----------TLTDY 131
           + +      PN++T        V     LV + ++      + +            L + 
Sbjct: 61  QAMSQCSH-PNVVTYYTSF--VVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEA 117

Query: 132 DIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPG------ 185
            I   + E+L+ LDY H  G +HRD+K  N+++  +   +++ D+G++ F   G      
Sbjct: 118 IIATILKEVLEGLDYLHRNGQIHRDLKAGNILLGEDG-SVQIADFGVSAFLATGGDVTRN 176

Query: 186 QEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRI 245
           +     V +  +  PE++   + YD+  DMWS G     +     P+             
Sbjct: 177 KVRKDFVGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYH------------ 224

Query: 246 AKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLL 305
                   +   +     +       +  +   K++ +                 L   L
Sbjct: 225 ----KYPPMKVLMLTLQNDPPTLETGVEDKEMMKKYGK------------SFRKLLSLCL 268

Query: 306 RYDHQSRLTAREAMEHPYFYTVVKDQARMGS--SSMPGGSTPVSSANMMSGIS 356
           + D   R TA E ++  +F      +  +    +  P  +        + G S
Sbjct: 269 QKDPSKRPTAAELLKCKFFQKAKNREYLIEKLLTRTPDIAQRAKKVRRVPGSS 321


>6ED6-A nrPDB
          Length = 415

 Score =  228 bits (581), Expect = 3e-60,   Method: Composition-based stats.
 Identities = 74/353 (20%), Positives = 130/353 (36%), Gaps = 64/353 (18%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVK------ILKPVKKKKIKREIKILENLRG 90
           +DY +V+ +GRG + EV    +  + +   +K      ++K         E  I+     
Sbjct: 88  EDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMA-FAN 146

Query: 91  GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTL--TDYDIRFYMYEILKALDYCH 148
            P ++ L    +D   R   +V E++   D   L       +   +FY  E++ ALD  H
Sbjct: 147 SPWVVQLFYAFQD--DRYLYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALDAIH 204

Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ--EYNVRVASRYFKGPELLVDY 206
           SMG++HRDVKP N+++D +H  L+L D+G             +  V +  +  PE+L   
Sbjct: 205 SMGLIHRDVKPDNMLLD-KHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQ 263

Query: 207 QM---YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNI 263
                Y    D WS+G  L  M+    PF+                        +  Y+ 
Sbjct: 264 GGDGFYGRECDWWSVGVFLYEMLVGDTPFYADS--------------------LVGTYSK 303

Query: 264 ELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRL---TAREAME 320
            +D + +      +               +S  A + +   L  D + RL      E  +
Sbjct: 304 IMDHKNSLCFPEDA--------------EISKHAKNLICAFLT-DREVRLGRNGVEEIRQ 348

Query: 321 HPYFYTVVKDQ---ARMGSSSMPGGSTPVSSANMMSG------ISSVPTPSPL 364
           HP+F              +  +P  S+ + S+N          + + P P   
Sbjct: 349 HPFFKNDQWHWDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVETFPIPKAF 401


>3HKO-A nrPDB
          Length = 345

 Score =  228 bits (581), Expect = 4e-60,   Method: Composition-based stats.
 Identities = 74/358 (20%), Positives = 129/358 (36%), Gaps = 95/358 (26%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKI--------LKPVKKKKIKREIKILEN 87
           Q  Y L   +G+G Y  V  AI         +KI        + P   ++IK E+++++ 
Sbjct: 25  QKKYHLKGAIGQGSYGVVRVAIENQTRAIRAIKIMNKNKIRQINPKDVERIKTEVRLMKK 84

Query: 88  LRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTL------------------- 128
           L   PNI  L ++ +D   +   LV E  +                              
Sbjct: 85  L-HHPNIARLYEVYED--EQYICLVMELCHGGHLLDKLNVFIDDSTGKCAMDVVKTQICP 141

Query: 129 ------------------------TDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMI 164
                                    +  I   M +I  AL Y H+ GI HRD+KP N + 
Sbjct: 142 CPECNEEAINGSIHGFRESLDFVQREKLISNIMRQIFSALHYLHNQGICHRDIKPENFLF 201

Query: 165 D-HEHRKLRLIDWGLAEFY---HPGQEY--NVRVASRYFKGPELLV-DYQMYDYSLDMWS 217
             ++  +++L+D+GL++ +   + G+ Y    +  + YF  PE+L    + Y    D WS
Sbjct: 202 STNKSFEIKLVDFGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEVLNTTNESYGPKCDAWS 261

Query: 218 LGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHS 277
            G +L  ++    PF  G ++ D + ++                                
Sbjct: 262 AGVLLHLLLMGAVPF-PGVNDADTISQVLN------------------------------ 290

Query: 278 RKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMG 335
               +    + N +++SP A D L  LL  +   R  A  A++HP+         +M 
Sbjct: 291 ---KKLCFENPNYNVLSPLARDLLSNLLNRNVDERFDAMRALQHPWISQFSDKIYKMS 345


>5UNP-A nrPDB
          Length = 369

 Score =  227 bits (580), Expect = 4e-60,   Method: Composition-based stats.
 Identities = 74/340 (21%), Positives = 147/340 (43%), Gaps = 44/340 (12%)

Query: 28  SHVVEWGNQDDYQLVRKLGRGKYSEVFEAI-NITNNEKVVVKILKPVKK--KKIKREIKI 84
            HV +W  Q+ Y++V  LG G +  V + + +     +V +KI+K V+K  +  + EI +
Sbjct: 26  YHVGDW-LQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINV 84

Query: 85  LENLR----GGPNI-ITLADIVKDPVSRTPALVFEHVNNTDFKQL----YQTLTDYDIRF 135
           LE +        N+ + + D           + FE +  + F  L    Y     + +R 
Sbjct: 85  LEKINEKDPDNKNLCVQMFDWF--DYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRH 142

Query: 136 YMYEILKALDYCHSMGIMHRDVKPHNVMI------------------DHEHRKLRLIDWG 177
             +++ +A+ + H   + H D+KP N++                     +   +R++D+G
Sbjct: 143 MAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFG 202

Query: 178 LAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHD 237
            A F    + ++  V++R+++ PE++++   +    D+WS+GC++          F  HD
Sbjct: 203 SATF--DHEHHSTIVSTRHYRAPEVILEL-GWSQPCDVWSIGCIIFEYYVGFT-LFQTHD 258

Query: 238 NYDQLVRIAKVLGTEDLYDYIDK------YNIELDPRFNDILGRHSRKRWERFVHSENQH 291
           N + L  + ++LG                Y   LD   N   GR+ R+  +         
Sbjct: 259 NREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSE 318

Query: 292 -LVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKD 330
                +  D ++ +L Y+   RLT  EA++HP+F  +  +
Sbjct: 319 AEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAE 358


>2X7G-A nrPDB
          Length = 389

 Score =  227 bits (580), Expect = 5e-60,   Method: Composition-based stats.
 Identities = 83/387 (21%), Positives = 151/387 (39%), Gaps = 77/387 (19%)

Query: 14  DVNTHRPREYWDYESHVVEWGN--QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK 71
           D     P +Y     H V+ G+     Y ++RKLG G +S V+   ++     V +K++K
Sbjct: 6   DEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVK 65

Query: 72  PVKK--KKIKREIKILENLR----GGPN---IITLADIVK--DPVSRTPALVFEHVNNTD 120
             +   +    EIK+L+ +R      PN   ++ L D  K          +VFE + +  
Sbjct: 66  SAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHL 125

Query: 121 FKQL----YQTLTDYDIRFYMYEILKALDYCHSM-GIMHRDVKPHNVMI----------- 164
            K +    YQ L    ++  + ++L+ LDY HS   I+H D+KP N+++           
Sbjct: 126 LKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMA 185

Query: 165 -----------------------------------DHEHRKLRLIDWGLAEFYHPGQEYN 189
                                              + +  ++++ D G A + H  + + 
Sbjct: 186 AEATEWQKAGAPPPSGSAVSTAPAADLLVNPLDPRNADKIRVKIADLGNACWVH--KHFT 243

Query: 190 VRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFH--GHD---NYDQLVR 244
             + +R ++  E+L+    Y    D+WS  CM   +      F    G D   + D +  
Sbjct: 244 EDIQTRQYRSIEVLIGA-GYSTPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAH 302

Query: 245 IAKVLGT-EDLYDYIDKYNIELDPRFNDILGRHSRKRWERF----VHSENQHLVSPEALD 299
           I ++LG+    +    KY+ E   R  ++      K W  F          H  + +  D
Sbjct: 303 IIELLGSIPRHFALSGKYSREFFNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTD 362

Query: 300 FLDKLLRYDHQSRLTAREAMEHPYFYT 326
           FL  +L    + R +A E + HP+  +
Sbjct: 363 FLIPMLEMVPEKRASAGECLRHPWLNS 389


>2I0E-A nrPDB
          Length = 353

 Score =  227 bits (578), Expect = 8e-60,   Method: Composition-based stats.
 Identities = 75/358 (20%), Positives = 123/358 (34%), Gaps = 66/358 (18%)

Query: 34  GNQD-----DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPV------KKKKIKREI 82
           GN+D     D+  +  LG+G + +V  +     +E   VKILK          +    E 
Sbjct: 12  GNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEK 71

Query: 83  KILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ---TLTDYDIRFYMYE 139
           ++L      P +  L    +         V E+VN  D     Q      +    FY  E
Sbjct: 72  RVLALPGKPPFLTQLHSCFQ--TMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAE 129

Query: 140 ILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF-YHPGQEYNVRVASRYFK 198
           I   L +  S GI++RD+K  NVM+D E   +++ D+G+ +     G        +  + 
Sbjct: 130 IAIGLFFLQSKGIIYRDLKLDNVMLDSEGH-IKIADFGMCKENIWDGVTTKTFCGTPDYI 188

Query: 199 GPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYI 258
            PE++  YQ Y  S+D W+ G +L  M+  + PF  G D  +    I +           
Sbjct: 189 APEIIA-YQPYGKSVDWWAFGVLLYEMLAGQAPF-EGEDEDELFQSIME----------- 235

Query: 259 DKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTA--- 315
                                      +      +S EA+     L+      RL     
Sbjct: 236 --------------------------HNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPE 269

Query: 316 --REAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLGPLAGSP 371
             R+  EH +F  +  ++        P    P +            T  P  P+   P
Sbjct: 270 GERDIKEHAFFRYIDWEKLERKEIQPP--YKPKACGRNAENFDRFFTRHP--PVLTPP 323


>4JDH-A nrPDB
          Length = 346

 Score =  226 bits (576), Expect = 1e-59,   Method: Composition-based stats.
 Identities = 71/332 (21%), Positives = 133/332 (40%), Gaps = 49/332 (14%)

Query: 1   MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDY--QLVRKLGRGKYSEVFEAIN 58
           M    P       +       ++      VV+ G+   Y    ++ +G G    V  A  
Sbjct: 37  MPEKPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIK-IGEGSTGIVCIATV 95

Query: 59  ITNNEKVVVKILKPVKKKK---IKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEH 115
            ++ + V VK +   K+++   +  E+ I+ + +   N++ + +     V     +V E 
Sbjct: 96  RSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQH-ENVVEMYNSY--LVGDELWVVMEF 152

Query: 116 VNNTDFKQL--YQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRL 173
           +       +  +  + +  I      +L+AL   H+ G++HRD+K  ++++ H+ R ++L
Sbjct: 153 LEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGR-VKL 211

Query: 174 IDWGL-AEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPF 232
            D+G  A+           V + Y+  PEL+     Y   +D+WSLG M+  M+  + P+
Sbjct: 212 SDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRL-PYGPEVDIWSLGIMVIEMVDGEPPY 270

Query: 233 FHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHL 292
           F+                 E     +      L PR  ++                  H 
Sbjct: 271 FN-----------------EPPLKAMKMIRDNLPPRLKNL------------------HK 295

Query: 293 VSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324
           VSP    FLD+LL  D   R TA E ++HP+ 
Sbjct: 296 VSPSLKGFLDRLLVRDPAQRATAAELLKHPFL 327


>4FIE-A nrPDB
          Length = 423

 Score =  226 bits (576), Expect = 1e-59,   Method: Composition-based stats.
 Identities = 71/332 (21%), Positives = 133/332 (40%), Gaps = 49/332 (14%)

Query: 1   MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDY--QLVRKLGRGKYSEVFEAIN 58
           M    P       +       ++      VV+ G+   Y    ++ +G G    V  A  
Sbjct: 114 MPEKPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIK-IGEGSTGIVCIATV 172

Query: 59  ITNNEKVVVKILKPVKKKK---IKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEH 115
            ++ + V VK +   K+++   +  E+ I+ + +   N++ + +     V     +V E 
Sbjct: 173 RSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQH-ENVVEMYNSY--LVGDELWVVMEF 229

Query: 116 VNNTDFKQL--YQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRL 173
           +       +  +  + +  I      +L+AL   H+ G++HRD+K  ++++ H+ R ++L
Sbjct: 230 LEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGR-VKL 288

Query: 174 IDWGL-AEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPF 232
            D+G  A+           V + Y+  PEL+     Y   +D+WSLG M+  M+  + P+
Sbjct: 289 SDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRL-PYGPEVDIWSLGIMVIEMVDGEPPY 347

Query: 233 FHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHL 292
           F+                 E     +      L PR  ++                  H 
Sbjct: 348 FN-----------------EPPLKAMKMIRDNLPPRLKNL------------------HK 372

Query: 293 VSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324
           VSP    FLD+LL  D   R TA E ++HP+ 
Sbjct: 373 VSPSLKGFLDRLLVRDPAQRATAAELLKHPFL 404


>4XBR-A nrPDB
          Length = 366

 Score =  225 bits (574), Expect = 3e-59,   Method: Composition-based stats.
 Identities = 66/287 (22%), Positives = 121/287 (42%), Gaps = 46/287 (16%)

Query: 44  KLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK---IKREIKILENLRGGPNIITLADI 100
           K+G G    V  A   ++ + V VK +   K+++   +  E+ I+ + +   N++ + + 
Sbjct: 101 KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQH-ENVVEMYNS 159

Query: 101 VKDPVSRTPALVFEHVNNTDFKQL--YQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVK 158
               V     +V E +       +  +  + +  I      +L+AL   H+ G++HRD+K
Sbjct: 160 Y--LVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIK 217

Query: 159 PHNVMIDHEHRKLRLIDWGL-AEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWS 217
             ++++ H+ R ++L D+G  A+           V + Y+  PEL+     Y   +D+WS
Sbjct: 218 SDSILLTHDGR-VKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRL-PYGPEVDIWS 275

Query: 218 LGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHS 277
           LG M+  M+  + P+F+                 E     +      L PR  ++     
Sbjct: 276 LGIMVIEMVDGEPPYFN-----------------EPPLKAMKMIRDNLPPRLKNL----- 313

Query: 278 RKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324
                        H VSP    FLD+LL  D   R TA E ++HP+ 
Sbjct: 314 -------------HKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFL 347


>1TKI-A nrPDB
          Length = 321

 Score =  224 bits (572), Expect = 4e-59,   Method: Composition-based stats.
 Identities = 68/301 (22%), Positives = 135/301 (44%), Gaps = 45/301 (14%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKI--KREIKILENLRGGPNI 94
           + Y +   LGRG++  V   +  ++ +  + K +K     ++  K+EI IL N+    NI
Sbjct: 5   EKYMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVKGTDQVLVKKEISIL-NIARHRNI 63

Query: 95  ITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----LTDYDIRFYMYEILKALDYCHSM 150
           + L +  +        ++FE ++  D  +   T    L + +I  Y++++ +AL + HS 
Sbjct: 64  LHLHESFESM--EELVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCEALQFLHSH 121

Query: 151 GIMHRDVKPHNVMI-DHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMY 209
            I H D++P N++        +++I++G A    PG  + +   +  +  PE+   + + 
Sbjct: 122 NIGHFDIRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLFTAPEYYAPEV-HQHDVV 180

Query: 210 DYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRF 269
             + DMWSLG ++  ++    PF    +       I  ++  E  +D             
Sbjct: 181 STATDMWSLGTLVYVLLSGINPFLAETNQQ----IIENIMNAEYTFD------------- 223

Query: 270 NDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 329
                             E    +S EA+DF+D+LL  + +SR+TA EA++HP+    ++
Sbjct: 224 -----------------EEAFKEISIEAMDFVDRLLVKERKSRMTASEALQHPWLKQKIE 266

Query: 330 D 330
            
Sbjct: 267 R 267


>2Q0N-A nrPDB
          Length = 301

 Score =  224 bits (572), Expect = 4e-59,   Method: Composition-based stats.
 Identities = 66/287 (22%), Positives = 121/287 (42%), Gaps = 46/287 (16%)

Query: 44  KLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK---IKREIKILENLRGGPNIITLADI 100
           K+G G    V  A   ++ + V VK +   K+++   +  E+ I+ + +   N++ + + 
Sbjct: 36  KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQH-ENVVEMYNS 94

Query: 101 VKDPVSRTPALVFEHVNNTDFKQL--YQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVK 158
               V     +V E +       +  +  + +  I      +L+AL   H+ G++HRD+K
Sbjct: 95  Y--LVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIK 152

Query: 159 PHNVMIDHEHRKLRLIDWGL-AEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWS 217
             ++++ H+ R ++L D+G  A+           V + Y+  PEL+     Y   +D+WS
Sbjct: 153 SDSILLTHDGR-VKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRL-PYGPEVDIWS 210

Query: 218 LGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHS 277
           LG M+  M+  + P+F+                 E     +      L PR  ++     
Sbjct: 211 LGIMVIEMVDGEPPYFN-----------------EPPLKAMKMIRDNLPPRLKNL----- 248

Query: 278 RKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324
                        H VSP    FLD+LL  D   R TA E ++HP+ 
Sbjct: 249 -------------HKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFL 282


>4C0T-A nrPDB
          Length = 974

 Score =  224 bits (572), Expect = 4e-59,   Method: Composition-based stats.
 Identities = 80/358 (22%), Positives = 133/358 (37%), Gaps = 66/358 (18%)

Query: 35  NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVK------ILKPVKKKKIKREIKILENL 88
           N  D++  ++LG G YS V  A +    ++  VK      I+K  K K +  E   L  L
Sbjct: 264 NVTDFKFGKELGEGSYSTVILATDKITGKQYAVKVLDKRHIIKEKKVKYVNIEKHALNRL 323

Query: 89  RGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ---TLTDYDIRFYMYEILKALD 145
                +I+L    +D  S     V ++ +N +   L +   TL +   R +  +IL A+ 
Sbjct: 324 SNRLGVISLYFTFQDKDS--LYFVLDYASNGELLTLIKRYNTLNEECTRHFGAQILDAIK 381

Query: 146 YCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHP----------GQEYNVRVASR 195
           Y H  G++HRD+KP N+++D +  ++++ D+G A                      V + 
Sbjct: 382 YMHDNGVIHRDLKPENILLD-DKMRIQITDFGTARLLEKKNDESEEYPVDVRAKSFVGTA 440

Query: 196 YFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLY 255
            +  PELL + +      D+W+ GC++  MI  K PF   ++                 +
Sbjct: 441 EYVSPELLEN-KYCGKPGDVWAFGCIIYQMIAGKPPFKATNEYL--------------TF 485

Query: 256 DYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTA 315
             I K        F  I+                         D + K+L      R T 
Sbjct: 486 QKITKLQFAFSAGFPTII------------------------RDLIKKILVLQPSRRATI 521

Query: 316 REAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLGPLAGSPVI 373
            E  +H +F +V          S P    P      M+  S +  P  L     + VI
Sbjct: 522 PEIQKHYFFQSVDFKDFDSIWLSDPPEIGP----YKMTAKSMMKVPE-LNKAPITTVI 574


>4U41-A nrPDB
          Length = 332

 Score =  223 bits (568), Expect = 1e-58,   Method: Composition-based stats.
 Identities = 62/309 (20%), Positives = 120/309 (38%), Gaps = 53/309 (17%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK--IKREIKILENLRGGPNIIT 96
           ++LV  +G G Y +V++  ++   +   +K++   + ++  IK EI +L+      NI T
Sbjct: 26  FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKKYSHHRNIAT 85

Query: 97  LADIV--KDPVSRT--PALVFEHVNNTDFKQLYQ-----TLTDYDIRFYMYEILKALDYC 147
                  K P        LV E         L +     TL +  I +   EIL+ L + 
Sbjct: 86  YYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAHL 145

Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGL-AEFYHPGQEYNVRVASRYFKGPELLVDY 206
           H   ++HRD+K  NV++  E+ +++L+D+G+ A+        N  + + Y+  PE++   
Sbjct: 146 HIHHVIHRDIKGQNVLLT-ENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACD 204

Query: 207 QM----YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYN 262
           +     YDY  D+WS G     M     P    H                          
Sbjct: 205 ENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMH-------------------------- 238

Query: 263 IELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHP 322
                R   ++ R+   R +    S+            ++  L  ++  R +  + ++HP
Sbjct: 239 ---PMRALFLIPRNPPPRLKSKKWSKKFFSF-------IEGCLVKNYMQRPSTEQLLKHP 288

Query: 323 YFYTVVKDQ 331
           +      ++
Sbjct: 289 FIRDQPNER 297


>4QMW-A nrPDB
          Length = 310

 Score =  222 bits (566), Expect = 2e-58,   Method: Composition-based stats.
 Identities = 66/329 (20%), Positives = 128/329 (38%), Gaps = 55/329 (16%)

Query: 3   GPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNN 62
           GP+ S    ++ V +  P          ++   ++ +  + K+G+G + EVF+ I+    
Sbjct: 1   GPLGSEFMAHSPVQSGLP------GMQNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQ 54

Query: 63  EKVVVKILK----PVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNN 118
           + V +KI+       + + I++EI +L      P +                ++ E++  
Sbjct: 55  KVVAIKIIDLEEAEDEIEDIQQEITVLSQC-DSPYVTKYYGSYLKDT--KLWIIMEYLGG 111

Query: 119 TDFKQLYQT--LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDW 176
                L +   L +  I   + EILK LDY HS   +HRD+K  NV++  EH +++L D+
Sbjct: 112 GSALDLLEPGPLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLL-SEHGEVKLADF 170

Query: 177 GLAEFYHPGQ-EYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHG 235
           G+A      Q + N  V + ++  PE++     YD   D+WSLG     +   + P    
Sbjct: 171 GVAGQLTDTQIKRNTFVGTPFWMAPEVI-KQSAYDSKADIWSLGITAIELARGEPP---- 225

Query: 236 HDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSP 295
                                             +++          +      +   S 
Sbjct: 226 ---------------------------------HSELHPMKVLFLIPKNNPPTLEGNYSK 252

Query: 296 EALDFLDKLLRYDHQSRLTAREAMEHPYF 324
              +F++  L  +   R TA+E ++H + 
Sbjct: 253 PLKEFVEACLNKEPSFRPTAKELLKHKFI 281


>4CRL-A nrPDB
          Length = 406

 Score =  222 bits (566), Expect = 2e-58,   Method: Composition-based stats.
 Identities = 78/321 (24%), Positives = 149/321 (46%), Gaps = 40/321 (12%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEK--VVVKILKPVKKKK-IKREIKILENLRGGPNI 94
           +Y+  +  GRG Y  V++A      +     +K ++         REI +L  L+  PN+
Sbjct: 24  EYEGCKV-GRGTYGHVYKAKRKDGKDDKDYALKQIEGTGISMSACREIALLRELKH-PNV 81

Query: 95  ITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ------------TLTDYDIRFYMYEILK 142
           I+L  +      R   L+F++  + D   + +             L    ++  +Y+IL 
Sbjct: 82  ISLQKVFLSHADRKVWLLFDYAEH-DLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILD 140

Query: 143 ALDYCHSMGIMHRDVKPHNVMI---DHEHRKLRLIDWGLAEFYH----PGQEYNVRVASR 195
            + Y H+  ++HRD+KP N+++     E  ++++ D G A  ++    P  + +  V + 
Sbjct: 141 GIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTF 200

Query: 196 YFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNY--------DQLVRIAK 247
           +++ PELL+  + Y  ++D+W++GC+ A ++  +  F    ++         DQL RI  
Sbjct: 201 WYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFN 260

Query: 248 VLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWER--FVHSENQHLVSPE--ALDFLDK 303
           V+G     D+ D   I+  P  + ++    R  +     +    +H V P+  A   L K
Sbjct: 261 VMGFPADKDWED---IKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQK 317

Query: 304 LLRYDHQSRLTAREAMEHPYF 324
           LL  D   R+T+ +AM+ PYF
Sbjct: 318 LLTMDPIKRITSEQAMQDPYF 338


>2XIK-A nrPDB
          Length = 294

 Score =  222 bits (566), Expect = 2e-58,   Method: Composition-based stats.
 Identities = 63/302 (20%), Positives = 118/302 (39%), Gaps = 49/302 (16%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK----PVKKKKIKREIKILENLRGG 91
           ++ +  + ++G+G + EV++ I+    E V +KI+       + + I++EI +L      
Sbjct: 18  EELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQC-DS 76

Query: 92  PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT--LTDYDIRFYMYEILKALDYCHS 149
           P I                ++ E++       L +   L +  I   + EILK LDY HS
Sbjct: 77  PYITRYFGSYLKST--KLWIIMEYLGGGSALDLLKPGPLEETYIATILREILKGLDYLHS 134

Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ-EYNVRVASRYFKGPELLVDYQM 208
              +HRD+K  NV++  E   ++L D+G+A      Q + N  V + ++  PE++     
Sbjct: 135 ERKIHRDIKAANVLL-SEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI-KQSA 192

Query: 209 YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPR 268
           YD+  D+WSLG     +   + P                                     
Sbjct: 193 YDFKADIWSLGITAIELAKGEPP------------------------------------- 215

Query: 269 FNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVV 328
            +D+          +      +   S    +F++  L  D + R TA+E ++H +     
Sbjct: 216 NSDLHPMRVLFLIPKNSPPTLEGQHSKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYT 275

Query: 329 KD 330
           K 
Sbjct: 276 KK 277


>5FET-A nrPDB
          Length = 847

 Score =  222 bits (565), Expect = 2e-58,   Method: Composition-based stats.
 Identities = 72/348 (20%), Positives = 136/348 (39%), Gaps = 61/348 (17%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVK------ILKPVKKKKIKREIKILENLR 89
             + +  R +GRG +  V    +     +  +K      I+   ++  IK E +I     
Sbjct: 532 MHELETERIIGRGTFGTVKLVHHKPTQIRYALKCVSKRSIISLNQQNNIKLEREITAE-N 590

Query: 90  GGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTL---TDYDIRFYMYEILKALDY 146
             P II L    KD  S     + E V   +     + L   +    +FY+  I+ A++Y
Sbjct: 591 DHPFIIRLVRTFKD--SNCFYFLTELVTGGELYDAIRKLGLLSKPQAQFYLGSIILAIEY 648

Query: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDY 206
            H   I++RD+KP N+++D +   ++LID+G A+    G+ Y   V + ++  PE+++  
Sbjct: 649 LHERNIVYRDLKPENILLDKQGY-VKLIDFGCAKKIQ-GRAYT-LVGTPHYMAPEVILG- 704

Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 266
           + Y  ++D+W+LG  L   I    PF  G+D  DQL     +L  +  +           
Sbjct: 705 KGYGCTVDIWALGVCLYEFICGPLPF--GNDQEDQLEIFRDILTGQLTFP---------- 752

Query: 267 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTA-----REAMEH 321
                                   ++   ++++ + +LL    Q R+       ++  EH
Sbjct: 753 -----------------------DYVSDQDSINLMKRLLCRLPQGRIGCSINGFKDIKEH 789

Query: 322 PYFYTVVKDQARMGSSSMPGGSTPVSSA-----NMMSGISSVPTPSPL 364
            +F     D+        P  S   + A       +    ++    PL
Sbjct: 790 AFFGNFNWDKLAGRLLEPPLVSKGETYAEDIDIKQIEEEDALNEGEPL 837


>3VN9-A nrPDB
          Length = 340

 Score =  222 bits (565), Expect = 2e-58,   Method: Composition-based stats.
 Identities = 68/341 (19%), Positives = 138/341 (40%), Gaps = 62/341 (18%)

Query: 5   VPSRARVYTDVNTHRPREYWDYESHVVEWGNQ------DDYQLVRKLGRGKYSEVFEAIN 58
           +P  A      ++  PR+        +  GNQ      DD + + +LGRG Y  V +  +
Sbjct: 15  IPKEAFEQPQTSSTPPRDL--DSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRH 72

Query: 59  ITNNEKVVVKILK----PVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFE 114
           + + + + VK ++      ++K++  ++ I       P  +T    +         +  E
Sbjct: 73  VPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGD--VWICME 130

Query: 115 HVNNTDFKQLY-------QTLTDYDIRFYMYEILKALDYCHSM-GIMHRDVKPHNVMIDH 166
            ++ T   + Y       QT+ +  +      I+KAL++ HS   ++HRDVKP NV+I+ 
Sbjct: 131 LMD-TSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINA 189

Query: 167 EHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELL---VDYQMYDYSLDMWSLGCMLA 223
              ++++ D+G++ +        +    + +  PE +   ++ + Y    D+WSLG  + 
Sbjct: 190 -LGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMI 248

Query: 224 SMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWER 283
            +   + P+      + QL ++ +                E  P+               
Sbjct: 249 ELAILRFPYDSWGTPFQQLKQVVE----------------EPSPQLP------------- 279

Query: 284 FVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324
                     S E +DF  + L+ + + R T  E M+HP+F
Sbjct: 280 ------ADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFF 314


>4WNO-A nrPDB
          Length = 287

 Score =  221 bits (563), Expect = 4e-58,   Method: Composition-based stats.
 Identities = 57/213 (26%), Positives = 106/213 (49%), Gaps = 22/213 (10%)

Query: 38  DYQLVRK--LGRGKYSEVFEAINITNNE-KVVVKILKPVKKKKIK----REIKILENLRG 90
            ++  RK  +G G ++ VF+  +   ++ +V VK +      K +    +EIKIL+ L+ 
Sbjct: 17  KFEFSRKDLIGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKH 76

Query: 91  GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYC 147
             NI+ L D  +  ++ +  LV E+ N  D        +TL++  IR ++ +I  A+   
Sbjct: 77  -ENIVALYDFQE--MANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLL 133

Query: 148 HSMGIMHRDVKPHNVMIDHEHR--------KLRLIDWGLAEFYHPGQEYNVRVASRYFKG 199
           HS GI+HRD+KP N+++ +           ++++ D+G A +            S  +  
Sbjct: 134 HSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMA 193

Query: 200 PELLVDYQMYDYSLDMWSLGCMLASMIFRKEPF 232
           PE+++  Q YD   D+WS+G ++   +  K PF
Sbjct: 194 PEVIMS-QHYDGKADLWSIGTIVYQCLTGKAPF 225


>2OU7-A nrPDB
          Length = 335

 Score =  221 bits (563), Expect = 4e-58,   Method: Composition-based stats.
 Identities = 65/330 (19%), Positives = 140/330 (42%), Gaps = 54/330 (16%)

Query: 45  LGRGKYSEVFEAINITNNEKVVVKI------LKPVKKKKIKREIKILENLRGGPNIITLA 98
           LG+G +++ FE  +    E    KI      LKP +++K+  EI I  +L    +++   
Sbjct: 49  LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQ-HVVGFH 107

Query: 99  DIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYCHSMGIMHR 155
              +D  +    +V E        +L++    LT+ + R+Y+ +I+    Y H   ++HR
Sbjct: 108 GFFED--NDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHR 165

Query: 156 DVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLD 214
           D+K  N+ ++ E  ++++ D+GLA +  + G+   V   +  +  PE+L   + + + +D
Sbjct: 166 DLKLGNLFLN-EDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVL-SKKGHSFEVD 223

Query: 215 MWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILG 274
           +WS+GC++ +++  K PF              +    ++ Y  I K    +         
Sbjct: 224 VWSIGCIMYTLLVGKPPF--------------ETSCLKETYLRIKKNEYSIPKH------ 263

Query: 275 RHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYT-VVKDQAR 333
                             ++P A   + K+L+ D  +R T  E +   +F +  +  +  
Sbjct: 264 ------------------INPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLP 305

Query: 334 MGSSSMPGGSTPVSSANMMSGISSVPTPSP 363
           +   ++P   +   S+   S    +   + 
Sbjct: 306 ITCLTIPPRFSIAPSSLDPSNRKPLTVLNK 335


>4WUA-A nrPDB
          Length = 401

 Score =  221 bits (563), Expect = 4e-58,   Method: Composition-based stats.
 Identities = 84/389 (21%), Positives = 153/389 (39%), Gaps = 79/389 (20%)

Query: 14  DVNTHRPREYWDYESHVVEWGN--QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK 71
           D     P +Y     H+V+ G+     Y ++RKLG G +S V+ + +I   + V +K++K
Sbjct: 16  DDEQEDPNDYCKGGYHLVKIGDLFNGRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVK 75

Query: 72  PVKK--KKIKREIKILENLRG-GPN------IITLADIVK--DPVSRTPALVFEHVNNTD 120
             +   +    EI++L+++R   PN      ++ L D  K          +VFE + +  
Sbjct: 76  SAEHYTETALDEIRLLKSVRNSDPNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHL 135

Query: 121 FKQL----YQTLTDYDIRFYMYEILKALDYCHSM-GIMHRDVKPHNVMI----------- 164
            K +    YQ L    ++  + ++L+ LDY H+   I+H D+KP N+++           
Sbjct: 136 LKWIIKSNYQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLA 195

Query: 165 -------------------------------------DHEHRKLRLIDWGLAEFYHPGQE 187
                                                + E  K+++ D G A + H  + 
Sbjct: 196 AEATEWQRSGAPPPSGSAVSTAPATAGNFLVNPLEPKNAEKLKVKIADLGNACWVH--KH 253

Query: 188 YNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGH-----DNYDQL 242
           +   + +R ++  E+L+    Y+   D+WS  CM   +      F          + D +
Sbjct: 254 FTEDIQTRQYRSLEVLIG-SGYNTPADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHI 312

Query: 243 VRIAKVLG-TEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPE----A 297
             I ++LG          KY+ E   +  D+      K W  F     ++  S E     
Sbjct: 313 ALIIELLGKVPRKLIVAGKYSKEFFTKKGDLKHITKLKPWGLFEVLVEKYEWSQEEAAGF 372

Query: 298 LDFLDKLLRYDHQSRLTAREAMEHPYFYT 326
            DFL  +L    + R TA E + HP+  +
Sbjct: 373 TDFLLPMLELIPEKRATAAECLRHPWLNS 401


>4J52-A nrPDB
          Length = 293

 Score =  221 bits (563), Expect = 4e-58,   Method: Composition-based stats.
 Identities = 62/292 (21%), Positives = 128/292 (43%), Gaps = 53/292 (18%)

Query: 45  LGRGKYSEVFEAINITNNEKVVVKI------LKPVKKKKIKREIKILENLRGGPNIITLA 98
           LG+G +++ FE  +    E    KI      LKP +++K+  EI I  +L    +++   
Sbjct: 22  LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQ-HVVGFH 80

Query: 99  DIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYCHSMGIMHR 155
              +D  +    +V E        +L++    LT+ + R+Y+ +I+    Y H   ++HR
Sbjct: 81  GFFED--NDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHR 138

Query: 156 DVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLD 214
           D+K  N+ ++ E  ++++ D+GLA +  + G+   V   +  +  PE+L   + + + +D
Sbjct: 139 DLKLGNLFLN-EDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVL-SKKGHSFEVD 196

Query: 215 MWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILG 274
           +WS+GC++ +++  K PF              +    ++ Y  I K    +         
Sbjct: 197 VWSIGCIMYTLLVGKPPF--------------ETSCLKETYLRIKKNEYSIPKH------ 236

Query: 275 RHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYT 326
                             ++P A   + K+L+ D  +R T  E +   +F +
Sbjct: 237 ------------------INPVAASLIQKMLQTDPTARPTINELLNDEFFTS 270


>4B8L-A nrPDB
          Length = 286

 Score =  221 bits (563), Expect = 4e-58,   Method: Composition-based stats.
 Identities = 67/298 (22%), Positives = 124/298 (41%), Gaps = 53/298 (17%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK------IKREIKILENLRG 90
           DD+ + R LG+GK+  V+ A    N   + +K+L   + +K      ++REI+I  +LR 
Sbjct: 15  DDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRREIEIQSHLRH 74

Query: 91  GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYC 147
            PNI+ + +   D   +   L+ E     +  +  Q      +     +M E+  AL YC
Sbjct: 75  -PNILRMYNYFHD--RKRIYLMLEFAPRGELYKELQKHGRFDEQRSATFMEELADALHYC 131

Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQ 207
           H   ++HRD+KP N+++ ++  +L++ D+G +  + P         +  +  PE++ + +
Sbjct: 132 HERKVIHRDIKPENLLMGYKG-ELKIADFGWS-VHAPSLRRRTMCGTLDYLPPEMI-EGK 188

Query: 208 MYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDP 267
            +D  +D+W  G +    +    PF     + +   RI  V                   
Sbjct: 189 THDEKVDLWCAGVLCYEFLVGMPPF-DSPSHTETHRRIVNV------------------- 228

Query: 268 RFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFY 325
                               +    +S  + D + KLLRY    RL  +  MEHP+  
Sbjct: 229 ------------------DLKFPPFLSDGSKDLISKLLRYHPPQRLPLKGVMEHPWVK 268


>2WO6-A nrPDB
          Length = 382

 Score =  221 bits (563), Expect = 4e-58,   Method: Composition-based stats.
 Identities = 78/337 (23%), Positives = 151/337 (44%), Gaps = 49/337 (14%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK--KKIKREIKILENLRGGP- 92
            D Y++   +G+G + +V +A +    E V +KI+K  K    + + E+++LE +     
Sbjct: 53  MDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDT 112

Query: 93  ----NIITLADIVKDPVSRTPALVFEHVNNTDFKQL----YQTLTDYDIRFYMYEILKAL 144
                I+ L             LVFE ++   +  L    ++ ++    R +  ++  AL
Sbjct: 113 EMKYYIVHLKRHF--MFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTAL 170

Query: 145 DYCH--SMGIMHRDVKPHNVMI-DHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPE 201
            +     + I+H D+KP N+++ + +   ++++D+G +     GQ     + SR+++ PE
Sbjct: 171 LFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQL--GQRIYQYIQSRFYRSPE 228

Query: 202 LLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTED-------- 253
           +L+    YD ++DMWSLGC+L  M    EP F G +  DQ+ +I +VLG           
Sbjct: 229 VLLGM-PYDLAIDMWSLGCILVEMHTG-EPLFSGANEVDQMNKIVEVLGIPPAHILDQAP 286

Query: 254 ------------------LYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSP 295
                               D   +Y      + ++ILG  +     R    E+ H V+ 
Sbjct: 287 KARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRR-AGESGHTVAD 345

Query: 296 --EALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKD 330
             +  D + ++L YD ++R+    A++H +F     +
Sbjct: 346 YLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADE 382


>6E2O-A nrPDB
          Length = 295

 Score =  221 bits (562), Expect = 6e-58,   Method: Composition-based stats.
 Identities = 67/335 (20%), Positives = 124/335 (37%), Gaps = 59/335 (17%)

Query: 19  RPREYWDYESHVVEWGNQDDYQLVR-----KLGRGKYSEVFEAINITNNEKVVVKILKPV 73
           R  E  D ES ++E+    DY+         LG+G Y  V+   +++N  ++ +K +   
Sbjct: 3   RSTEEGDCESDLLEY----DYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPER 58

Query: 74  KK---KKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTL-- 128
                + +  EI + ++L+   NI+       +  +    +  E V       L ++   
Sbjct: 59  DSRYSQPLHEEIALHKHLKH-KNIVQYLGSFSE--NGFIKIFMEQVPGGSLSALLRSKWG 115

Query: 129 ----TDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHP 184
                +  I FY  +IL+ L Y H   I+HRD+K  NV+I+     L++ D+G ++    
Sbjct: 116 PLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAG 175

Query: 185 GQEYN-VRVASRYFKGPELL-VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQL 242
                     +  +  PE++    + Y  + D+WSLGC +  M   K PF+   +    +
Sbjct: 176 INPCTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAM 235

Query: 243 VRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLD 302
            ++                                       VH E    +S EA  F+ 
Sbjct: 236 FKVGM-----------------------------------FKVHPEIPESMSAEAKAFIL 260

Query: 303 KLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSS 337
           K    D   R  A + +   +   V   + +    
Sbjct: 261 KCFEPDPDKRACANDLLVDEFLK-VSSKKKKTQPK 294


>3C51-A nrPDB
          Length = 543

 Score =  220 bits (561), Expect = 8e-58,   Method: Composition-based stats.
 Identities = 79/337 (23%), Positives = 128/337 (37%), Gaps = 58/337 (17%)

Query: 23  YWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK------K 76
           +  ++    +   +D +   R LGRG + EVF        +    K L   +       +
Sbjct: 171 FLQWKWLEAQPMGEDWFLDFRVLGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQ 230

Query: 77  KIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY-------QTLT 129
               E KIL  +     I++LA   +        LV   +N  D +              
Sbjct: 231 GAMVEKKILAKV-HSRFIVSLAYAFETKTD--LCLVMTIMNGGDIRYHIYNVDEDNPGFQ 287

Query: 130 DYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ-EY 188
           +    FY  +I+  L++ H   I++RD+KP NV++D +   +R+ D GLA     GQ + 
Sbjct: 288 EPRAIFYTAQIVSGLEHLHQRNIIYRDLKPENVLLDDDG-NVRISDLGLAVELKAGQTKT 346

Query: 189 NVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKV 248
                +  F  PELL+  + YD+S+D ++LG  L  MI  + PF    +  +      +V
Sbjct: 347 KGYAGTPGFMAPELLLGEE-YDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKQRV 405

Query: 249 LGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYD 308
           L  E    Y DK+                                SP + DF + LL+ D
Sbjct: 406 L--EQAVTYPDKF--------------------------------SPASKDFCEALLQKD 431

Query: 309 HQSRL-----TAREAMEHPYFYTVVKDQARMGSSSMP 340
            + RL     +      HP F  +   Q   G  + P
Sbjct: 432 PEKRLGFRDGSCDGLRTHPLFRDISWRQLEAGMLTPP 468


>6QAU-A nrPDB
          Length = 280

 Score =  220 bits (560), Expect = 1e-57,   Method: Composition-based stats.
 Identities = 60/211 (28%), Positives = 106/211 (50%), Gaps = 20/211 (9%)

Query: 38  DYQLVRKLGRGKYSEVFEAINI-TNNEKVVVKILKPVKKKKIK----REIKILENLRGGP 92
           +Y     +G G ++ VF   +    + +V +K +      K +    +EIKIL+ L+   
Sbjct: 12  EYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKILKELQH-E 70

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ---TLTDYDIRFYMYEILKALDYCHS 149
           NI+ L D+ + P S    LV E+ N  D     Q   TL++  IR ++++I  A+   HS
Sbjct: 71  NIVALYDVQELPNS--VFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRILHS 128

Query: 150 MGIMHRDVKPHNVMIDHEHR--------KLRLIDWGLAEFYHPGQEYNVRVASRYFKGPE 201
            GI+HRD+KP N+++ + +R        ++++ D+G A + H          S  +  PE
Sbjct: 129 KGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAADLCGSPMYMAPE 188

Query: 202 LLVDYQMYDYSLDMWSLGCMLASMIFRKEPF 232
           +++  Q YD   D+WS+G ++   +  K PF
Sbjct: 189 VIMS-QHYDAKADLWSIGTVIYQCLVGKPPF 218


>4AF3-A nrPDB
          Length = 292

 Score =  219 bits (559), Expect = 1e-57,   Method: Composition-based stats.
 Identities = 70/296 (23%), Positives = 127/296 (42%), Gaps = 53/296 (17%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK------IKREIKILENLRG 90
           DD+++ R LG+GK+  V+ A    ++  V +K+L   + +K      ++REI+I  +L  
Sbjct: 23  DDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHL-H 81

Query: 91  GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ---TLTDYDIRFYMYEILKALDYC 147
            PNI+ L +   D   R   L+ E+    +  +  Q   T  +      M E+  AL YC
Sbjct: 82  HPNILRLYNYFYD--RRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYC 139

Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQ 207
           H   ++HRD+KP N+ +     +L++ D+G +  + P         +  +  PE++ + +
Sbjct: 140 HGKKVIHRDIKPENL-LLGLKGELKIADFGWS-VHAPSLRRKTMCGTLDYLPPEMI-EGR 196

Query: 208 MYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDP 267
           M++  +D+W +G +   ++    PF     N +   RI KV                 D 
Sbjct: 197 MHNEKVDLWCIGVLCYELLVGNPPFESASHN-ETYRRIVKV-----------------DL 238

Query: 268 RFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323
           +F   +                       A D + KLLR++   RL   +   HP+
Sbjct: 239 KFPASVPTG--------------------AQDLISKLLRHNPSERLPLAQVSAHPW 274


>4FZF-B nrPDB
          Length = 283

 Score =  218 bits (556), Expect = 3e-57,   Method: Composition-based stats.
 Identities = 61/296 (20%), Positives = 116/296 (39%), Gaps = 49/296 (16%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK----PVKKKKIKREIKILENLRGG 91
           ++ +  + ++G+G + EVF+ I+    + V +KI+       + + I++EI +L      
Sbjct: 7   EELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSS 66

Query: 92  PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT--LTDYDIRFYMYEILKALDYCHS 149
             +                ++ E++       L +     ++ I   + EILK LDY HS
Sbjct: 67  -YVTKYYGSY--LKGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHS 123

Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ-EYNVRVASRYFKGPELLVDYQM 208
              +HRD+K  NV++  E   ++L  +G+A      Q + N  V + ++  PE++     
Sbjct: 124 EKKIHRDIKAANVLL-SEQGDVKLAAFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQ-SA 181

Query: 209 YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPR 268
           YD   D+WSLG     +   + P                              N ++ P 
Sbjct: 182 YDSKADIWSLGITAIELAKGEPP------------------------------NSDMHPM 211

Query: 269 FNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324
              +L    +      V        +    +F+D  L  D   R TA+E ++H + 
Sbjct: 212 --RVLFLIPKNNPPTLVGD-----FTKSFKEFIDACLNKDPSFRPTAKELLKHKFI 260


>6CQF-A nrPDB
          Length = 297

 Score =  217 bits (554), Expect = 4e-57,   Method: Composition-based stats.
 Identities = 63/295 (21%), Positives = 121/295 (41%), Gaps = 46/295 (15%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPV---KKKKIKREIKILENLRGGP 92
           +D Y L+++LG G Y EVF+A +  + + V +K++K         +++EI IL+  R   
Sbjct: 15  RDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRHA- 73

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ---TLTDYDIRFYMYEILKALDYCHS 149
           NI+           +   +  E       + +YQ   +L++  I +   E+L+ L Y HS
Sbjct: 74  NIVAYHGSY--LWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHS 131

Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYN-VRVASRYFKGPEL--LVDY 206
              +HRD+K  N++I+ +  ++RL D+G++             + + Y+  PE+  +   
Sbjct: 132 QKKIHRDIKGANILIN-DAGEVRLADFGISAQIGATLARRLAFIGTPYWMAPEVAAVALK 190

Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 266
             Y+   D+WSLG     +   + P F  H                    ++   +    
Sbjct: 191 GGYNELCDIWSLGITAIELAELQPPLFDVH---------------PLRVLFLMTKSGYQP 235

Query: 267 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEH 321
           PR  +      + +W            S    +F+   L    + R +A + + H
Sbjct: 236 PRLKE------KGKW------------SAAFHNFIKVTLTKSPKKRPSATKMLSH 272


>4FR4-A nrPDB
          Length = 384

 Score =  217 bits (554), Expect = 5e-57,   Method: Composition-based stats.
 Identities = 57/322 (17%), Positives = 126/322 (39%), Gaps = 54/322 (16%)

Query: 35  NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK------KKIKREIKILENL 88
           N D ++++R +G+G + +V         +   +K +   K       + + +E++I++ L
Sbjct: 13  NFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQGL 72

Query: 89  RGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALD 145
              P ++ L    +D       +V + +   D +   Q      +  ++ ++ E++ ALD
Sbjct: 73  EH-PFLVNLWYSFQD--EEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELVMALD 129

Query: 146 YCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVD 205
           Y  +  I+HRD+KP N+++D EH  + + D+ +A       +      ++ +  PE+   
Sbjct: 130 YLQNQRIIHRDMKPDNILLD-EHGHVHITDFNIAAMLPRETQITTMAGTKPYMAPEMFSS 188

Query: 206 YQ--MYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNI 263
            +   Y +++D WSLG     ++  + P+            I     ++++    +   +
Sbjct: 189 RKGAGYSFAVDWWSLGVTAYELLRGRRPY-----------HIRSSTSSKEIVHTFETTVV 237

Query: 264 ELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT-AREAMEHP 322
                +                        S E +  L KLL  +   R +   +    P
Sbjct: 238 TYPSAW------------------------SQEMVSLLKKLLEPNPDQRFSQLSDVQNFP 273

Query: 323 YFYTVVKD---QARMGSSSMPG 341
           Y   +  D   Q R+    +P 
Sbjct: 274 YMNDINWDAVFQKRLIPGFIPN 295


>2VD5-A nrPDB
          Length = 412

 Score =  217 bits (554), Expect = 5e-57,   Method: Composition-based stats.
 Identities = 84/371 (22%), Positives = 132/371 (35%), Gaps = 61/371 (16%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKI------LKPVKKKKIKREIKILENLR 89
           +DD+++++ +GRG +SEV         +   +KI      LK  +    + E  +L N  
Sbjct: 60  RDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVN-G 118

Query: 90  GGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTD----YDIRFYMYEILKALD 145
               I  L    +D       LV E+    D   L     +       RFY+ EI+ A+D
Sbjct: 119 DRRWITQLHFAFQD--ENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAID 176

Query: 146 YCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVR--VASRYFKGPELL 203
             H +G +HRD+KP N+++D     +RL D+G                V +  +  PE+L
Sbjct: 177 SVHRLGYVHRDIKPDNILLDR-CGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEIL 235

Query: 204 V------DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDY 257
                      Y    D W+LG     M + + PF+                 T + Y  
Sbjct: 236 QAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADS--------------TAETYGK 281

Query: 258 IDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRL---T 314
           I  Y                    E          V  EA DF+ +LL    ++RL    
Sbjct: 282 IVHYK-------------------EHLSLPLVDEGVPEEARDFIQRLLCP-PETRLGRGG 321

Query: 315 AREAMEHPYFYTVVKDQARMG-SSSMPGGSTPVSSANMMSGISSVPTPSPLGPLAGSPVI 373
           A +   HP+F+ +  D  R       P       + N       +      G    S + 
Sbjct: 322 AGDFRTHPFFFGLDWDGLRDSVPPFTPDFEGATDTCNFDLVEDGLTAMVSGGGETLSDIR 381

Query: 374 AAANPLGMPVP 384
             A PLG+ +P
Sbjct: 382 EGA-PLGVHLP 391


>4OTD-A nrPDB
          Length = 341

 Score =  217 bits (553), Expect = 6e-57,   Method: Composition-based stats.
 Identities = 76/358 (21%), Positives = 138/358 (38%), Gaps = 62/358 (17%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP------VKKKKIKREIKILENL-- 88
           +D++ +  LGRG + +V  +    + E   +K LK        + + +  E +IL  +  
Sbjct: 12  EDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTS 71

Query: 89  RGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT--LTDYDIRFYMYEILKALDY 146
            G P ++ L    + P       V E+    D      +   ++    FY   ++  L +
Sbjct: 72  AGHPFLVNLFGCFQTP--EHVCFVMEYSAGGDLMLHIHSDVFSEPRAIFYSACVVLGLQF 129

Query: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF-YHPGQEYNVRVASRYFKGPELLVD 205
            H   I++RD+K  N+++D E   +++ D+GL +     G   +    +  F  PE+L D
Sbjct: 130 LHEHKIVYRDLKLDNLLLDTEGY-VKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTD 188

Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIEL 265
              Y  ++D W LG +L  M+  + PF  G D  +    I                    
Sbjct: 189 TS-YTRAVDWWGLGVLLYEMLVGESPF-PGDDEEEVFDSIVN------------------ 228

Query: 266 DPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT-----AREAME 320
                         R+ RF        +S EA+  + +LLR + + RL      A +  +
Sbjct: 229 -----------DEVRYPRF--------LSAEAIGIMRRLLRRNPERRLGSSERDAEDVKK 269

Query: 321 HPYFYTVVKDQA---RMGSSSMPGGSTPVSSANMMSGISSVPTPSPLGPLAGSPVIAA 375
            P+F T+  +     R+    +P  S     +N     +    P+   P    P+ AA
Sbjct: 270 QPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFDEEFTGE-APTLSPPRDARPLTAA 326


>5UUU-A nrPDB
          Length = 547

 Score =  217 bits (552), Expect = 8e-57,   Method: Composition-based stats.
 Identities = 73/322 (22%), Positives = 129/322 (40%), Gaps = 55/322 (17%)

Query: 35  NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREI-----KILENL- 88
             +D+ + R +GRG + EV+        +   +K L   + K  + E      +I+ +L 
Sbjct: 196 TMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLV 255

Query: 89  --RGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKA 143
                P I+ ++     P     + + + +N  D           ++ D+RFY  EI+  
Sbjct: 256 STGDCPFIVCMSYAFHTP--DKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILG 313

Query: 144 LDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELL 203
           L++ H+  +++RD+KP N+++D EH  +R+ D GLA  +   ++ +  V +  +  PE+L
Sbjct: 314 LEHMHNRFVVYRDLKPANILLD-EHGHVRISDLGLACDFSK-KKPHASVGTHGYMAPEVL 371

Query: 204 VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNI 263
                YD S D +SLGCML  ++    PF                    ++        +
Sbjct: 372 QKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKH-----------EIDRMTLTMAV 420

Query: 264 ELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRL-----TAREA 318
           EL   F                        SPE    L+ LL+ D   RL      A+E 
Sbjct: 421 ELPDSF------------------------SPELRSLLEGLLQRDVNRRLGCLGRGAQEV 456

Query: 319 MEHPYFYTVVKDQARMGSSSMP 340
            E P+F ++      +     P
Sbjct: 457 KESPFFRSLDWQMVFLQKYPPP 478


>3PVW-A nrPDB
          Length = 695

 Score =  216 bits (550), Expect = 2e-56,   Method: Composition-based stats.
 Identities = 73/322 (22%), Positives = 129/322 (40%), Gaps = 55/322 (17%)

Query: 35  NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREI-----KILENL- 88
             +D+ + R +GRG + EV+        +   +K L   + K  + E      +I+ +L 
Sbjct: 187 TMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLV 246

Query: 89  --RGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKA 143
                P I+ ++     P     + + + +N  D           ++ D+RFY  EI+  
Sbjct: 247 STGDCPFIVCMSYAFHTP--DKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILG 304

Query: 144 LDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELL 203
           L++ H+  +++RD+KP N+++D EH  +R+ D GLA  +   ++ +  V +  +  PE+L
Sbjct: 305 LEHMHNRFVVYRDLKPANILLD-EHGHVRISDLGLACDFSK-KKPHASVGTHGYMAPEVL 362

Query: 204 VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNI 263
                YD S D +SLGCML  ++    PF                    ++        +
Sbjct: 363 QKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKH-----------EIDRMTLTMAV 411

Query: 264 ELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRL-----TAREA 318
           EL   F                        SPE    L+ LL+ D   RL      A+E 
Sbjct: 412 ELPDSF------------------------SPELRSLLEGLLQRDVNRRLGCLGRGAQEV 447

Query: 319 MEHPYFYTVVKDQARMGSSSMP 340
            E P+F ++      +     P
Sbjct: 448 KESPFFRSLDWQMVFLQKYPPP 469


>2BRG-A nrPDB
          Length = 297

 Score =  215 bits (547), Expect = 3e-56,   Method: Composition-based stats.
 Identities = 69/321 (21%), Positives = 130/321 (40%), Gaps = 49/321 (15%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK----KKIKREIKILENLRGGP 92
           +D+ LV+ LG G Y EV  A+N    E V VKI+   +     + IK+EI I + L    
Sbjct: 7   EDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKML-NHE 65

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYCHS 149
           N++               L  E+ +  +     +    + + D + + ++++  + Y H 
Sbjct: 66  NVVKFYG--HRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHG 123

Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE---YNVRVASRYFKGPELLVDY 206
           +GI HRD+KP N+++D E   L++ D+GLA  +         N    +  +  PELL   
Sbjct: 124 IGITHRDIKPENLLLD-ERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRR 182

Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 266
           + +   +D+WS G +L +M+  + P+    D+             ++  D+ +K      
Sbjct: 183 EFHAEPVDVWSCGIVLTAMLAGELPWDQPSDS------------CQEYSDWKEKKTYLNP 230

Query: 267 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYT 326
            +  D                             L K+L  +  +R+T  +  +  ++  
Sbjct: 231 WKKIDSAPLA-----------------------LLHKILVENPSARITIPDIKKDRWYNK 267

Query: 327 VVKDQARMGSSSMPGGSTPVS 347
            +K  A+    +  G S   S
Sbjct: 268 PLKKGAKRPRVTSGGVSESPS 288


>3ALO-A nrPDB
          Length = 327

 Score =  213 bits (543), Expect = 9e-56,   Method: Composition-based stats.
 Identities = 59/335 (17%), Positives = 130/335 (38%), Gaps = 60/335 (17%)

Query: 17  THRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPV--- 73
              P ++WD+ +        +D + + ++GRG Y  V + ++  + + + VK ++     
Sbjct: 10  KISPEQHWDFTA--------EDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDE 61

Query: 74  -KKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ------ 126
            ++K++  ++ ++      P I+     +         +  E ++ T F + Y+      
Sbjct: 62  KEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDC--WICMELMS-TSFDKFYKYVYSVL 118

Query: 127 --TLTDYDIRFYMYEILKALDYCHSM-GIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH 183
              + +  +       +KAL++      I+HRD+KP N+++D     ++L D+G++    
Sbjct: 119 DDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSG-NIKLCDFGISGQLV 177

Query: 184 PGQEYNVRVASRYFKGPELL---VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYD 240
                      R +  PE +      Q YD   D+WSLG  L  +   + P+   +  +D
Sbjct: 178 DSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFD 237

Query: 241 QLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDF 300
           QL ++ K  G                                  + +  +   SP  ++F
Sbjct: 238 QLTQVVK--GDPPQ------------------------------LSNSEEREFSPSFINF 265

Query: 301 LDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMG 335
           ++  L  D   R   +E ++HP+     +    + 
Sbjct: 266 VNLCLTKDESKRPKYKELLKHPFILMYEERAVEVA 300


>6CCF-A nrPDB
          Length = 290

 Score =  213 bits (542), Expect = 1e-55,   Method: Composition-based stats.
 Identities = 61/323 (18%), Positives = 124/323 (38%), Gaps = 76/323 (23%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVV----------------------------- 67
           + Y+L  ++G+G Y  V  A N + +    +                             
Sbjct: 5   NQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGG 64

Query: 68  --KILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQ-- 123
             K L P+  +++ +EI IL+ L    N++ L +++ DP      LVF+ +      +  
Sbjct: 65  PAKQLLPL--ERVYQEIAILKKL-DHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEVP 121

Query: 124 LYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH 183
             +  ++   R Y+ +++  L+Y H   I+HRD+KP N+++  +   +++ D+G++  + 
Sbjct: 122 CDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGH-VKIADFGVSNQFE 180

Query: 184 -PGQEYNVRVASRYFKGPELLVDYQ--MYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYD 240
               + +    +  F  PE + D        +LD+W+ G  L   ++ K PF        
Sbjct: 181 GNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFID------ 234

Query: 241 QLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDF 300
                                         D +    RK     V    +  +S E  D 
Sbjct: 235 ------------------------------DFILALHRKIKNEPVVFPEEPEISEELKDL 264

Query: 301 LDKLLRYDHQSRLTAREAMEHPY 323
           + K+L  + ++R+   +   HP+
Sbjct: 265 ILKMLDKNPETRIGVPDIKLHPW 287


>4APC-A nrPDB
          Length = 350

 Score =  212 bits (540), Expect = 2e-55,   Method: Composition-based stats.
 Identities = 57/292 (19%), Positives = 127/292 (43%), Gaps = 28/292 (9%)

Query: 25  DYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVK-----ILKPVKKKKIK 79
           D  +  + + + + Y  ++K+G G + +     +  +  + V+K      +   ++++ +
Sbjct: 12  DLGTENLYFQSMEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESR 71

Query: 80  REIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT-----LTDYDIR 134
           RE+ +L N++  PNI+   +  ++  S    +V ++    D  +           +  I 
Sbjct: 72  REVAVLANMKH-PNIVQYRESFEENGS--LYIVMDYCEGGDLFKRINAQKGVLFQEDQIL 128

Query: 135 FYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEY-NVRVA 193
            +  +I  AL + H   I+HRD+K  N+ +  +   ++L D+G+A   +   E     + 
Sbjct: 129 DWFVQICLALKHVHDRKILHRDIKSQNIFLTKDG-TVQLGDFGIARVLNSTVELARACIG 187

Query: 194 SRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTED 253
           + Y+  PE + + + Y+   D+W+LGC+L  +   K  F  G      L  I+       
Sbjct: 188 TPYYLSPE-ICENKPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVS 246

Query: 254 LYDYIDKYNIELDPRFNDILGRHSRKRW-------ERFVHSENQHLVSPEAL 298
           L+     Y+ +L    + +  R+ R R        + F+    +  +SP+ +
Sbjct: 247 LH-----YSYDLRSLVSQLFKRNPRDRPSVNSILEKGFIAKRIEKFLSPQLI 293


>2JD5-A nrPDB
          Length = 373

 Score =  212 bits (539), Expect = 2e-55,   Method: Composition-based stats.
 Identities = 90/346 (26%), Positives = 148/346 (42%), Gaps = 45/346 (13%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK--PVKKKKIKREIKILENLRGGPN-- 93
            Y LVRKLG G +S V+ A ++ NN  V +KI++   V  +  + EIK+L+ +    N  
Sbjct: 20  RYILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVRGDKVYTEAAEDEIKLLQRVNDADNTK 79

Query: 94  --------IITLADIV--KDPVSRTPALVFEHVNNTDF----KQLYQTLTDYDIRFYMYE 139
                   I+ L D    K P      +VFE +         K  ++ +    ++    +
Sbjct: 80  EDSMGANHILKLLDHFNHKGPNGVHVVMVFEVLGENLLALIKKYEHRGIPLIYVKQISKQ 139

Query: 140 ILKALDYCHSM-GIMHRDVKPHNVMIDHEHR-----KLRLIDWGLAEFYHPGQEYNVRVA 193
           +L  LDY H   GI+H D+KP NV+++         ++++ D G A +Y   + Y   + 
Sbjct: 140 LLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNACWY--DEHYTNSIQ 197

Query: 194 SRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFH--GHD---NYDQLVRIAKV 248
           +R ++ PE+L+    +    D+WS  C++  +I     F    GH    + D + +I ++
Sbjct: 198 TREYRSPEVLLGA-PWGCGADIWSTACLIFELITGDFLFEPDEGHSYTKDDDHIAQIIEL 256

Query: 249 LGTEDLYDY-IDKYNIELDPRFNDILGRHSRKRWE-RFVHSENQHLVSPEAL---DFLDK 303
           LG    Y     KY          +      K W    V +E       EA    DFL  
Sbjct: 257 LGELPSYLLRNGKYTRTFFNSRGLLRNISKLKFWPLEDVLTEKYKFSKDEAKEISDFLSP 316

Query: 304 LLRYDHQSRLTAREAMEHPYFYTV-------VKDQARMGSSS-MPG 341
           +L+ D + R  A   + HP+           V D+   GS S +PG
Sbjct: 317 MLQLDPRKRADAGGLVNHPWLKDTLGMEEIRVPDRELYGSGSDIPG 362


>3FME-A nrPDB
          Length = 290

 Score =  211 bits (538), Expect = 3e-55,   Method: Composition-based stats.
 Identities = 61/303 (20%), Positives = 127/303 (41%), Gaps = 54/303 (17%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK----PVKKKKIKREIKILENLRGGP 92
           DD + + +LGRG Y  V +  ++ + + + VK ++      ++K++  ++ I       P
Sbjct: 7   DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCP 66

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNTDFKQLY-------QTLTDYDIRFYMYEILKALD 145
             +T    +         +  E ++ T   + Y       QT+ +  +      I+KAL+
Sbjct: 67  FTVTFYGALFREGD--VWICMELMD-TSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALE 123

Query: 146 YCHSM-GIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELL- 203
           + HS   ++HRDVKP NV+I+    ++++ D+G++ +       ++    + +  PE + 
Sbjct: 124 HLHSKLSVIHRDVKPSNVLINA-LGQVKMCDFGISGYLVDDVAKDIDAGCKPYMAPERIN 182

Query: 204 --VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKY 261
             ++ + Y    D+WSLG  +  +   + P+      + QL ++ +              
Sbjct: 183 PELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVE-------------- 228

Query: 262 NIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEH 321
             E  P+                         S E +DF  + L+ + + R T  E M+H
Sbjct: 229 --EPSPQLP-------------------ADKFSAEFVDFTSQCLKKNSKERPTYPELMQH 267

Query: 322 PYF 324
           P+F
Sbjct: 268 PFF 270


>4CSV-A nrPDB
          Length = 275

 Score =  211 bits (538), Expect = 4e-55,   Method: Composition-based stats.
 Identities = 53/275 (19%), Positives = 118/275 (42%), Gaps = 34/275 (12%)

Query: 20  PREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK--PVKKKK 77
           P + W+          + +  L RKLG G++ EV+E      N +V VK LK   +  ++
Sbjct: 2   PHDKWEIP--------RSEITLERKLGSGQFGEVYEGKWRNYNIEVAVKTLKEGTMSVEE 53

Query: 78  IKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ-----TLTDYD 132
             +E +I++ L+  PN++ L  +          ++ E++++       +     T+    
Sbjct: 54  FLQEAQIMKKLKH-PNLVQLYGVCTKEP--PIYIITEYMSHGSLLDYLRDCEGHTVNAQA 110

Query: 133 IRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRV 192
           +     ++   + Y  S   +HRD+   N ++  E+  +++ D+GLA   +   EY  R 
Sbjct: 111 LLDMAAQVASGMAYLESQNFIHRDLAARNCLVG-ENNVVKVADFGLARLINED-EYTARA 168

Query: 193 ASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVL 249
            +++   +  PE +  Y  +    D+W+ G +L  +    +  + G    + + ++ +  
Sbjct: 169 GAKFPIKWTAPEAI-SYNRFSIKSDVWAFGILLWEIFTYGQVPYPGMSGSEVIEQVERGY 227

Query: 250 -------GTEDLYDYIDKY---NIELDPRFNDILG 274
                    E++Y+ + +    + E  P F + L 
Sbjct: 228 RMPRPQGCPEEIYELMLQCWNKSPEERPTFAETLH 262


>6BXI-A nrPDB
          Length = 333

 Score =  211 bits (537), Expect = 4e-55,   Method: Composition-based stats.
 Identities = 69/372 (18%), Positives = 136/372 (36%), Gaps = 93/372 (25%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPV---KKKK---IKREIKILENLRG 90
           +D++ ++ +GRG + EV             +KIL+     +K++   I+ E  IL     
Sbjct: 6   EDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVE-AD 64

Query: 91  GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYC 147
              ++ +    +D +     L+ E +   D   L     TLT+ + +FY+ E + A+D  
Sbjct: 65  SLWVVKMFYSFQDKL--NLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSI 122

Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA---EFYHPGQEYN--------------- 189
           H +G +HRD+KP N+++D +   ++L D+GL    +  H  + Y                
Sbjct: 123 HQLGFIHRDIKPDNLLLDSKGH-VKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNM 181

Query: 190 ------------------VRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEP 231
                               V +  +  PE+ +    Y+   D WSLG ++  M+    P
Sbjct: 182 NSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQT-GYNKLCDWWSLGVIMYEMLIGYPP 240

Query: 232 FFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQH 291
           F       +   ++                                   W+  +    + 
Sbjct: 241 FCS-ETPQETYKKVMN---------------------------------WKETLTFPPEV 266

Query: 292 LVSPEALDFLDK-LLRYDHQSRLTA---REAMEHPYFYTVVKDQARMGSSSMPGGSTPVS 347
            +S +A D + +    ++H  R+ A    E   + +F  V  +  R   +++   S  + 
Sbjct: 267 PISEKAKDLILRFCCEWEH--RIGAPGVEEIKSNSFFEGVDWEHIRERPAAI---SIEIK 321

Query: 348 SANMMSGISSVP 359
           S +  S     P
Sbjct: 322 SIDDTSNFDEFP 333


>5TQX-A nrPDB
          Length = 655

 Score =  211 bits (537), Expect = 5e-55,   Method: Composition-based stats.
 Identities = 65/296 (21%), Positives = 122/296 (41%), Gaps = 31/296 (10%)

Query: 32  EWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKI----LKPVKKKKIKREIKILEN 87
           E+G    +++  +LG G +  V    +   + K+ +K     L    +++   EI+I++ 
Sbjct: 3   EFGAGGPWEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCHEIQIMKK 62

Query: 88  LRGGPNIITLADIVKDP---VSRTPALVFEHVNNTDFKQLYQT------LTDYDIRFYMY 138
           L    N++   D+ ++    +   P L  E+ +  D ++L         L +  I   + 
Sbjct: 63  LNHA-NVVKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLS 121

Query: 139 EILKALDYCHSMGIMHRDVKPHNVMIDHEHRKL--RLIDWGLAEFYHPGQEYNVRVASRY 196
           +I   + Y H   I+HRD+KP N+++     K+  ++ID G A+    G+     V +  
Sbjct: 122 DIGSGIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGELCTEFVGTLQ 181

Query: 197 FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYD 256
           +  PE L + + Y  ++D WS G M+   I    PF H    +    +I K    +D   
Sbjct: 182 YLAPE-LFENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKK----KDPKC 236

Query: 257 YIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSR 312
                 +  + RF+  L + +          EN           L  +L +D Q R
Sbjct: 237 IFACEEMSGEVRFSSHLPQPNSLCSLIVEPMENW----------LQLMLNWDPQQR 282


>1U5R-A nrPDB
          Length = 348

 Score =  211 bits (537), Expect = 5e-55,   Method: Composition-based stats.
 Identities = 70/296 (23%), Positives = 123/296 (41%), Gaps = 54/296 (18%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILK------PVKKKKIKREIKILENLRGGP 92
           +  +R++G G +  V+ A ++ N+E V +K +         K + I +E++ L+ LR  P
Sbjct: 56  FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRH-P 114

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNT--DFKQLYQT-LTDYDIRFYMYEILKALDYCHS 149
           N I            T  LV E+   +  D  ++++  L + +I    +  L+ L Y HS
Sbjct: 115 NTIQYRGCYLR--EHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHS 172

Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELL--VDYQ 207
             ++HRDVK  N+++  E   ++L D+G A    P    N  V + Y+  PE++  +D  
Sbjct: 173 HNMIHRDVKAGNILL-SEPGLVKLGDFGSASIMAPA---NSFVGTPYWMAPEVILAMDEG 228

Query: 208 MYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDP 267
            YD  +D+WSLG     +  RK P F+  +    L  IA+                    
Sbjct: 229 QYDGKVDVWSLGITCIELAERKPPLFN-MNAMSALYHIAQ-------------------- 267

Query: 268 RFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323
                              +      S    +F+D  L+   Q R T+   ++H +
Sbjct: 268 ---------------NESPALQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRF 308


>2GCD-A nrPDB
          Length = 309

 Score =  210 bits (535), Expect = 7e-55,   Method: Composition-based stats.
 Identities = 70/296 (23%), Positives = 123/296 (41%), Gaps = 54/296 (18%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILK------PVKKKKIKREIKILENLRGGP 92
           +  +R++G G +  V+ A ++ N+E V +K +         K + I +E++ L+ LR  P
Sbjct: 17  FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRH-P 75

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNT--DFKQLYQT-LTDYDIRFYMYEILKALDYCHS 149
           N I            T  LV E+   +  D  ++++  L + +I    +  L+ L Y HS
Sbjct: 76  NTIQYRGCY--LREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHS 133

Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELL--VDYQ 207
             ++HRDVK  N+++  E   ++L D+G A    P    N  V + Y+  PE++  +D  
Sbjct: 134 HNMIHRDVKAGNILL-SEPGLVKLGDFGSASIMAPA---NSFVGTPYWMAPEVILAMDEG 189

Query: 208 MYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDP 267
            YD  +D+WSLG     +  RK P F+  +    L  IA+                    
Sbjct: 190 QYDGKVDVWSLGITCIELAERKPPLFN-MNAMSALYHIAQ-------------------- 228

Query: 268 RFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323
                              +      S    +F+D  L+   Q R T+   ++H +
Sbjct: 229 ---------------NESPALQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRF 269


>3M42-A nrPDB
          Length = 299

 Score =  209 bits (532), Expect = 2e-54,   Method: Composition-based stats.
 Identities = 71/328 (21%), Positives = 127/328 (38%), Gaps = 75/328 (22%)

Query: 37  DDYQLV-RKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNII 95
           DDY++  + LG G   +V +  N    EK  +K+L      K +RE+++       P+I+
Sbjct: 17  DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML--QDCPKARREVELHWRASQCPHIV 74

Query: 96  TLADIVKD--PVSRTPALVFEHVNNTDFKQLYQ-----TLTDYDIRFYMYEILKALDYCH 148
            + D+ ++     +   +V E ++  +     Q       T+ +    M  I +A+ Y H
Sbjct: 75  RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 134

Query: 149 SMGIMHRDVKPHNVMIDHE--HRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDY 206
           S+ I HRDVKP N++   +  +  L+L D+G A+                          
Sbjct: 135 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKET----------------------TG 172

Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 266
           + YD S DMWSLG ++  ++    PF+  H           +  +  +   I     E  
Sbjct: 173 EKYDKSCDMWSLGVIMYILLCGYPPFYSNH----------GLAISPGMKTRIRMGQYEFP 222

Query: 267 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYT 326
                               +     VS E    +  LL+ +   R+T  E M HP+   
Sbjct: 223 --------------------NPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI-- 260

Query: 327 VVKDQARMGSSSMPGGSTPVSSANMMSG 354
                  M S+ +P   TP+ ++ ++  
Sbjct: 261 -------MQSTKVP--QTPLHTSRVLKE 279


>4OLI-A nrPDB
          Length = 645

 Score =  209 bits (532), Expect = 2e-54,   Method: Composition-based stats.
 Identities = 68/301 (22%), Positives = 128/301 (42%), Gaps = 26/301 (8%)

Query: 6   PSRARVYTDVNTHRPREYWDYESHVVEWGNQD------DY-QLVRKLGRGKYSEV----F 54
           PS   +  D+   +P    D  +   +    D       Y + +R LG G + +V    +
Sbjct: 315 PSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCY 374

Query: 55  EAINITNNEKVVVKILK----PVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPA 110
           +  N    E V VK LK    P  +   K+EI IL  L    +II      +D   ++  
Sbjct: 375 DPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYH-EHIIKYKGCCEDQGEKSLQ 433

Query: 111 LVFEHVNNTDFKQLY--QTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEH 168
           LV E+V     +      ++    +  +  +I + + Y HS   +HR++   NV++D++ 
Sbjct: 434 LVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHSQHYIHRNLAARNVLLDND- 492

Query: 169 RKLRLIDWGLAEFYHPGQEYN----VRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLAS 224
           R +++ D+GLA+    G EY        +  ++  PE L +Y+ Y Y+ D+WS G  L  
Sbjct: 493 RLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFY-YASDVWSFGVTLYE 551

Query: 225 MIFRKEPFFHGHDNYDQLVRIAK-VLGTEDLYDYIDKYNIELDP-RFNDILGRHSRKRWE 282
           ++   +        + +L+ IA+  +    L + +++      P +    +    +  WE
Sbjct: 552 LLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWE 611

Query: 283 R 283
            
Sbjct: 612 T 612



 Score = 83.5 bits (205), Expect = 1e-16,   Method: Composition-based stats.
 Identities = 37/299 (12%), Positives = 84/299 (28%), Gaps = 69/299 (23%)

Query: 56  AINITNNEKVVVKILKPVKKK---KIKREIKILENLRGGPNIITLADIVKDPVSRTPALV 112
             +     +VV+K+L P              ++  +    ++  +  +          +V
Sbjct: 88  GRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHT-HLAFVHGVCVRGPENI--MV 144

Query: 113 FEHVNNTDFKQLYQT----LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEH 168
            E+V +       +     +          ++  AL Y  +  ++H +V   N+++    
Sbjct: 145 TEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLG 204

Query: 169 RK------LRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDY-QMYDYSLDMWSLGCM 221
                   ++L D G+       +E   R+    +  PE L         ++D W  G  
Sbjct: 205 LAEGTSPFIKLSDPGVGLGALSREERVERI---PWLAPECLPGGANSLSTAMDKWGFGAT 261

Query: 222 LASMIF-RKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKR 280
           L  + F  + P                          +   +      F     R     
Sbjct: 262 LLEICFDGEAP--------------------------LQSRSPSEKEHFYQRQHRLPEPS 295

Query: 281 WERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSM 339
             +                   + L Y+   R +         F T+++D  R+   ++
Sbjct: 296 CPQLAT-------------LTSQCLTYEPTQRPS---------FRTILRDLTRLQPHNL 332


>4F9B-A nrPDB
          Length = 361

 Score =  209 bits (531), Expect = 2e-54,   Method: Composition-based stats.
 Identities = 82/340 (24%), Positives = 144/340 (42%), Gaps = 54/340 (15%)

Query: 39  YQLVRKLGRGKYSEVFEAI---NITNNEKVVVKILKPVKKK-KIKREIKILENLRGGPNI 94
           +++  K+G G +S V+ A     +   EK+ +K L P     +I  E++ L    G  N+
Sbjct: 23  FKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQCLTVAGGQDNV 82

Query: 95  ITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMH 154
           + +    +   +    +   ++ +  F  +  +L+  ++R YM  + KAL   H  GI+H
Sbjct: 83  MGVKYCFR--KNDHVVIAMPYLEHESFLDILNSLSFQEVREYMLNLFKALKRIHQFGIVH 140

Query: 155 RDVKPHNVMIDHEHRKLRLIDWGLAEFYHPG----------------------------- 185
           RDVKP N + +   +K  L+D+GLA+  H                               
Sbjct: 141 RDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNKCSICLSRR 200

Query: 186 QEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRI 245
           Q+   R  +  F+ PE+L        ++DMWS G +  S++  + PF+   D+   L +I
Sbjct: 201 QQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDDLTALAQI 260

Query: 246 AKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERF------------------VHS 287
             + G+ +       +   +     ++  +  RK  ER                    + 
Sbjct: 261 MTIRGSRETIQAAKTFGKSILCS-KEVPAQDLRKLCERLRGMDSSTPKLTSDIQGHATNL 319

Query: 288 ENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTV 327
           E  + V  EA D LDKLL  +  SR+TA EA+ HP+F  +
Sbjct: 320 EGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFFKDM 359


>4CRS-A nrPDB
          Length = 341

 Score =  209 bits (531), Expect = 2e-54,   Method: Composition-based stats.
 Identities = 73/356 (20%), Positives = 128/356 (35%), Gaps = 67/356 (18%)

Query: 35  NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP------VKKKKIKREIKILENL 88
           N  D++    L RG + +V  A     NE   +K LK        +   +  E +I E +
Sbjct: 10  NLQDFRCCAVLLRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETV 69

Query: 89  RG--GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT--LTDYDIRFYMYEILKAL 144
                P ++ L    +         V E+    D      T   ++    FY   ++  L
Sbjct: 70  NSVRHPFLVNLFACFQ--TKEHVCFVMEYAAGGDLMMHIHTDVFSEPRAVFYAACVVLGL 127

Query: 145 DYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF-YHPGQEYNVRVASRYFKGPELL 203
            Y H   I++RD+K  N+++D E   +++ D+GL +     G   +    +  F  PE+L
Sbjct: 128 QYLHEHKIVYRDLKLDNLLLDTEGF-VKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVL 186

Query: 204 VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNI 263
            +   Y  ++D W LG ++  M+  + PF  G D  +    I                  
Sbjct: 187 TETS-YTRAVDWWGLGVLIYEMLVGESPF-PGDDEEEVFDSIVN---------------- 228

Query: 264 ELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTARE-----A 318
                           R+ RF        +S EA+  + +LLR + + RL A E      
Sbjct: 229 -------------DEVRYPRF--------LSTEAISIMRRLLRRNPERRLGASEKDAEDV 267

Query: 319 MEHPYFYTVVKD---QARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLGPLAGSP 371
            +HP+F  +        ++    +P        +N     +S        P+   P
Sbjct: 268 KKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNFDDEFTSE------APILTPP 317


>4KIK-B nrPDB
          Length = 677

 Score =  208 bits (530), Expect = 3e-54,   Method: Composition-based stats.
 Identities = 64/298 (21%), Positives = 117/298 (39%), Gaps = 44/298 (14%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKI----LKPVKKKKIKREIKILENLRGGPNI 94
           +++  +LG G +  V    N    E++ +K     L P  +++   EI+I+  L   PN+
Sbjct: 21  WEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQIMRRLTH-PNV 79

Query: 95  ITLADIVKDP----VSRTPALVFEHVNNTDFKQLYQTLT------DYDIRFYMYEILKAL 144
           +   D+ +       +  P L  E+    D ++            +  I   + +I  AL
Sbjct: 80  VAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASAL 139

Query: 145 DYCHSMGIMHRDVKPHNVMIDHEHRKL--RLIDWGLAEFYHPGQEYNVRVASRYFKGPEL 202
            Y H   I+HRD+KP N+++    ++L  ++ID G A+    G      V +  +  PEL
Sbjct: 140 RYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPEL 199

Query: 203 LVDYQMYDYSLDMWSLGCMLASMIFRKEPFFH------GHDNYDQLVRIAKVLGTEDLYD 256
           L + Q Y  ++D WS G +    I    PF         H    Q   +  ++ +EDL  
Sbjct: 200 L-EQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEV-DIVVSEDLNG 257

Query: 257 YIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT 314
            +   +    P   + +     ++W                   L  +L +  + R T
Sbjct: 258 TVKFSSSLPYPNNLNSVLAERLEKW-------------------LQLMLMWHPRQRGT 296


>4YHJ-A nrPDB
          Length = 584

 Score =  208 bits (530), Expect = 3e-54,   Method: Composition-based stats.
 Identities = 68/340 (20%), Positives = 123/340 (36%), Gaps = 55/340 (16%)

Query: 22  EYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK------K 75
           ++  ++    +   ++ ++  R LG+G + EV         +    K L+  +      +
Sbjct: 170 QFLQWKWLERQPVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGE 229

Query: 76  KKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY-----QTLTD 130
                E +ILE ++    +++LA   +        LV   +N  D K            +
Sbjct: 230 AMALNEKRILEKVQ-SRFVVSLAYAYE--TKDALCLVLTIMNGGDLKFHIYNLGNPGFDE 286

Query: 131 YDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNV 190
               FY  E+   L+      I++RD+KP N+++D +   +R+ D GLA     GQ    
Sbjct: 287 QRAVFYAAELCCGLEDLQRERIVYRDLKPENILLD-DRGHIRISDLGLATEIPEGQRVRG 345

Query: 191 RVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLG 250
           RV +  +  PE++ + + Y +S D W LGC++  MI    PF           +  + + 
Sbjct: 346 RVGTVGYMAPEVV-NNEKYTFSPDWWGLGCLIYEMIQGHSPF----------KKYKEKVK 394

Query: 251 TEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQ 310
            E++   I     E   +F                        S +A      LL  +  
Sbjct: 395 WEEVDQRIKNDTEEYSEKF------------------------SEDAKSICRMLLTKNPS 430

Query: 311 SRL-----TAREAMEHPYFYTVVKDQARMGSSSMPGGSTP 345
            RL      A    +HP F  +   +        P    P
Sbjct: 431 KRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDP 470


>6DBM-A nrPDB
          Length = 318

 Score =  206 bits (525), Expect = 1e-53,   Method: Composition-based stats.
 Identities = 62/261 (23%), Positives = 116/261 (44%), Gaps = 19/261 (7%)

Query: 39  YQLVRKLGRGKYSEV----FEAINITNNEKVVVKILK----PVKKKKIKREIKILENLRG 90
            + +R LG G + +V    ++  N    E V VK LK    P  +   K+EI IL  L  
Sbjct: 33  LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAGPQHRSGWKQEIDILRTLYH 92

Query: 91  GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY--QTLTDYDIRFYMYEILKALDYCH 148
             +II      +D  + +  LV E+V     +      ++    +  +  +I + + Y H
Sbjct: 93  -EHIIKYKGCCEDAGAASLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLH 151

Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYN----VRVASRYFKGPELLV 204
           S   +HRD+   NV++D++ R +++ D+GLA+    G EY        +  ++  PE L 
Sbjct: 152 SQHYIHRDLAARNVLLDND-RLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLK 210

Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAK-VLGTEDLYDYIDKYNI 263
           +Y+ Y Y+ D+WS G  L  ++   +        + +L+ IA+  +    L + +++   
Sbjct: 211 EYKFY-YASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGER 269

Query: 264 ELDP-RFNDILGRHSRKRWER 283
              P +    +    +  WE 
Sbjct: 270 LPRPDKCPAEVYHLMKNCWET 290


>3EQC-A nrPDB
          Length = 360

 Score =  206 bits (525), Expect = 1e-53,   Method: Composition-based stats.
 Identities = 65/333 (19%), Positives = 128/333 (38%), Gaps = 26/333 (7%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKI----LKPVKKKKIKREIKILENLRGGP 92
           DD++ + +LG G    VF+  +  +   +  K+    +KP  + +I RE+++L      P
Sbjct: 33  DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHEC-NSP 91

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYC-H 148
            I+              ++  EH++     Q+ +    + +  +      ++K L Y   
Sbjct: 92  YIVGFYGAFYS--DGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLRE 149

Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQM 208
              IMHRDVKP N++++    +++L D+G++         N  V +R +  PE L     
Sbjct: 150 KHKIMHRDVKPSNILVNSRG-EIKLCDFGVSGQLIDSMA-NSFVGTRSYMSPERLQGT-H 206

Query: 209 YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLG--------TEDLYDYIDK 260
           Y    D+WS+G  L  M   + P         +L+   +V G               ++K
Sbjct: 207 YSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLNK 266

Query: 261 YNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAME 320
           + ++  P     +                  + S E  DF++K L  +   R   ++ M 
Sbjct: 267 FGMDSRP--PMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMV 324

Query: 321 HPYFYTVVKDQARMGSS--SMPGGSTPVSSANM 351
           H +      ++        S  G + P +  + 
Sbjct: 325 HAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHA 357


>3QA8-A nrPDB
          Length = 676

 Score =  206 bits (525), Expect = 1e-53,   Method: Composition-based stats.
 Identities = 55/212 (25%), Positives = 99/212 (46%), Gaps = 18/212 (8%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKI----LKPVKKKKIKREIKILENLRGGPNI 94
           +++  +LG G +  V   I+    E+V +K     L P  +++   EI+I++ L   PN+
Sbjct: 16  WEMKERLGTGGFGYVLRWIHQDTGEQVAIKQCRQELSPKNRERWCLEIQIMKKL-NHPNV 74

Query: 95  ITLADI----VKDPVSRTPALVFEHVNNTDFKQLYQT------LTDYDIRFYMYEILKAL 144
           ++  ++     K   +  P L  E+    D ++          L +  IR  + +I  AL
Sbjct: 75  VSAREVPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGPIRTLLSDISSAL 134

Query: 145 DYCHSMGIMHRDVKPHNVMIDHEHRKL--RLIDWGLAEFYHPGQEYNVRVASRYFKGPEL 202
            Y H   I+HRD+KP N+++    ++L  ++ID G A+    G+     V +  +  PEL
Sbjct: 135 RYLHENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQGELCTEFVGTLQYLAPEL 194

Query: 203 LVDYQMYDYSLDMWSLGCMLASMIFRKEPFFH 234
           L + + Y  ++D WS G +    I    PF  
Sbjct: 195 L-EQKKYTVTVDYWSFGTLAFECITGFRPFLP 225


>5KKR-C nrPDB
          Length = 395

 Score =  206 bits (525), Expect = 1e-53,   Method: Composition-based stats.
 Identities = 65/331 (19%), Positives = 126/331 (38%), Gaps = 22/331 (6%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKI----LKPVKKKKIKREIKILENLRGGP 92
           DD++ + +LG G    VF+  +  +   +  K+    +KP  + +I RE+++L      P
Sbjct: 68  DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHEC-NSP 126

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYC-H 148
            I+              ++  EH++     Q+ +    + +  +      ++K L Y   
Sbjct: 127 YIVGFYGAFYS--DGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLRE 184

Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQM 208
              IMHRDVKP N++++    +++L D+G++         N  V +R +  PE L     
Sbjct: 185 KHKIMHRDVKPSNILVNSRG-EIKLCDFGVSGQLIDSMA-NSFVGTRSYMSPERLQGT-H 241

Query: 209 YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKY------N 262
           Y    D+WS+G  L  M   + P         +L+   +V G         +       +
Sbjct: 242 YSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSS 301

Query: 263 IELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHP 322
             +D R    +                  + S E  DF++K L  +   R   ++ M H 
Sbjct: 302 YGMDSRPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFVNKCLIKNPAERADLKQLMVHA 361

Query: 323 YFYTVVKDQARMGSS--SMPGGSTPVSSANM 351
           +      ++        S  G + P +  + 
Sbjct: 362 FIKRSDAEEVDFAGWLCSTIGLNQPSTPTHA 392


>2XNP-A nrPDB
          Length = 279

 Score =  206 bits (524), Expect = 1e-53,   Method: Composition-based stats.
 Identities = 66/306 (21%), Positives = 123/306 (40%), Gaps = 58/306 (18%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK-----PVKKKKIKREIKILENLRGG 91
           +DY+++  +G G Y    +    ++ + +V K L        +K+ +  E+ +L  L+  
Sbjct: 6   EDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKH- 64

Query: 92  PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY-------QTLTDYDIRFYMYEILKAL 144
           PNI+   D + D  + T  +V E+    D   +        Q L +  +   M ++  AL
Sbjct: 65  PNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLAL 124

Query: 145 DYCHSMG-----IMHRDVKPHNVMIDHEHRKLRLIDWGLAEFY-HPGQEYNVRVASRYFK 198
             CH        ++HRD+KP NV +D + + ++L D+GLA    H        V + Y+ 
Sbjct: 125 KECHRRSDGGHTVLHRDLKPANVFLDGK-QNVKLGDFGLARILNHDTSFAKTFVGTPYYM 183

Query: 199 GPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYI 258
            PE + +   Y+   D+WSLGC+L  +     PF      + Q                 
Sbjct: 184 SPEQM-NRMSYNEKSDIWSLGCLLYELCALMPPF----TAFSQ----------------- 221

Query: 259 DKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREA 318
                       ++ G+    ++ R       +  S E  + + ++L      R +  E 
Sbjct: 222 -----------KELAGKIREGKFRRIP-----YRYSDELNEIITRMLNLKDYHRPSVEEI 265

Query: 319 MEHPYF 324
           +E+P  
Sbjct: 266 LENPLI 271


>2WQN-A nrPDB
          Length = 310

 Score =  206 bits (523), Expect = 2e-53,   Method: Composition-based stats.
 Identities = 64/259 (24%), Positives = 115/259 (44%), Gaps = 21/259 (8%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKI------LKPVKKKKIKREIKILENLRGG 91
           ++++ +K+GRG++SEV+ A  + +   V +K       +    +    +EI +L+ L   
Sbjct: 33  NFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQL-NH 91

Query: 92  PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTL-------TDYDIRFYMYEILKAL 144
           PN+I       +       +V E  +  D  ++ +          +  +  Y  ++  AL
Sbjct: 92  PNVIKYYASFIE--DNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSAL 149

Query: 145 DYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHP-GQEYNVRVASRYFKGPELL 203
           ++ HS  +MHRD+KP NV I      ++L D GL  F+       +  V + Y+  PE +
Sbjct: 150 EHMHSRRVMHRDIKPANVFITATG-VVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERI 208

Query: 204 VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNI 263
            +   Y++  D+WSLGC+L  M   + PF+    N   L +  +      L    D Y+ 
Sbjct: 209 HE-NGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPS--DHYSE 265

Query: 264 ELDPRFNDILGRHSRKRWE 282
           EL    N  +     KR +
Sbjct: 266 ELRQLVNMCINPDPEKRPD 284


>4E20-A nrPDB
          Length = 290

 Score =  204 bits (519), Expect = 5e-53,   Method: Composition-based stats.
 Identities = 53/219 (24%), Positives = 100/219 (45%), Gaps = 17/219 (7%)

Query: 39  YQLVRKLGRGKYSEV----FEAINITNNEKVVVKILK----PVKKKKIKREIKILENLRG 90
            + +R LG G + +V    ++  N    E V VK LK    P  +   +REI+IL  L  
Sbjct: 10  LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSGWQREIEILRTLYH 69

Query: 91  GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY--QTLTDYDIRFYMYEILKALDYCH 148
             +I+      +D   ++  LV E+V     +       +    +  +  +I + + Y H
Sbjct: 70  -EHIVKYKGCCEDQGEKSVQLVMEYVPLGSLRDYLPRHCVGLAQLLLFAQQICEGMAYLH 128

Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYN----VRVASRYFKGPELLV 204
           +   +HR +   NV++D++ R +++ D+GLA+    G EY        +  ++  PE L 
Sbjct: 129 AQHYIHRALAARNVLLDND-RLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLK 187

Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLV 243
           + + Y Y+ D+WS G  L  ++   +     H  + +L+
Sbjct: 188 ECKFY-YASDVWSFGVTLYELLTYCDSNQSPHTKFTELI 225


>4PWN-A nrPDB
          Length = 274

 Score =  203 bits (516), Expect = 1e-52,   Method: Composition-based stats.
 Identities = 53/295 (17%), Positives = 111/295 (37%), Gaps = 50/295 (16%)

Query: 44  KLGRGKYSEVFEAINITNNEKVVV-----KILKPVKKKKIKREIKILENLRGGPNIITLA 98
           ++GRG +  V++ ++     +V       + L   ++++ K E ++L+ L+  PNI+   
Sbjct: 17  EIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQH-PNIVRFY 75

Query: 99  DIVKD--PVSRTPALVFEHVNNTDFKQLYQTLTDYDI---RFYMYEILKALDYCHSMG-- 151
           D  +      +   LV E + +   K   +      I   R +  +ILK L + H+    
Sbjct: 76  DSWESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKGLQFLHTRTPP 135

Query: 152 IMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDY 211
           I+HRD+K  N+ I      +++ D GLA            + +  F  PE+  +   YD 
Sbjct: 136 IIHRDLKCDNIFITGPTGSVKIGDLGLATLEKRASFAKSVIGTPEFMAPEMYEE--KYDE 193

Query: 212 SLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFND 271
           S+D+++ G  +  M   + P+    +      R+                          
Sbjct: 194 SVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVT------------------------- 228

Query: 272 ILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYT 326
                          +    +  PE  + ++  +R +   R + ++ + H +F  
Sbjct: 229 ----------SGVKPASFDKVAIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQE 273


>5O2C-A nrPDB
          Length = 380

 Score =  201 bits (512), Expect = 4e-52,   Method: Composition-based stats.
 Identities = 57/316 (18%), Positives = 118/316 (37%), Gaps = 51/316 (16%)

Query: 44  KLGRGKYSEVFEAINITNNEKVVV-----KILKPVKKKKIKREIKILENLRGGPNIITLA 98
           +LGRG +  V++ ++     +V       + L   ++++ K E ++L+ L+  PNI+   
Sbjct: 32  ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQH-PNIVRFY 90

Query: 99  DIVKD--PVSRTPALVFEHVNNTDFKQLYQTLT---DYDIRFYMYEILKALDYCHSMG-- 151
           D  +      +   LV E + +   K   +         +R +  +ILK L + H+    
Sbjct: 91  DSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPP 150

Query: 152 IMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDY 211
           I+HRD+K  N+ I      +++ D GLA            + +  F  PE+  ++  YD 
Sbjct: 151 IIHRDLKCDNIFITGPTGSVKIGDLGLATLMRT-SFAKSVIGTPEFMAPEMYEEH--YDE 207

Query: 212 SLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFND 271
           S+D+++ G  +  M   + P+    +                                  
Sbjct: 208 SVDVYAFGMCMLEMATSEYPYSECQN---------------------------------- 233

Query: 272 ILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQ 331
              +  RK       +    +  PE  + ++  +R +   RL+ R+ + H +F      +
Sbjct: 234 -AAQIYRKVTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLR 292

Query: 332 ARMGSSSMPGGSTPVS 347
             +        S+   
Sbjct: 293 VELAEEDDCSNSSLAL 308


>5O2B-A nrPDB
          Length = 285

 Score =  201 bits (512), Expect = 4e-52,   Method: Composition-based stats.
 Identities = 56/295 (18%), Positives = 114/295 (38%), Gaps = 51/295 (17%)

Query: 44  KLGRGKYSEVFEAINITNNEKVVV-----KILKPVKKKKIKREIKILENLRGGPNIITLA 98
           +LGRG +  V++ ++     +V       + L   ++++ K E ++L+ L+  PNI+   
Sbjct: 23  ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQH-PNIVRFY 81

Query: 99  DIVKD--PVSRTPALVFEHVNNTDFKQLYQTLT---DYDIRFYMYEILKALDYCHSMG-- 151
           D  +      +   LV E + +   K   +         +R +  +ILK L + H+    
Sbjct: 82  DSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPP 141

Query: 152 IMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDY 211
           I+HRD+K  N+ I      +++ D GLA            + +  F  PE+  ++  YD 
Sbjct: 142 IIHRDLKCDNIFITGPTGSVKIGDLGLATLMRT-SFAKSVIGTPEFMAPEMYEEH--YDE 198

Query: 212 SLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFND 271
           S+D+++ G  +  M   + P+    +                                  
Sbjct: 199 SVDVYAFGMCMLEMATSEYPYSECQN---------------------------------- 224

Query: 272 ILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYT 326
              +  RK       +    +  PE  + ++  +R +   RL+ R+ + H +F  
Sbjct: 225 -AAQIYRKVTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAE 278


>6GQK-A nrPDB
          Length = 328

 Score =  200 bits (509), Expect = 9e-52,   Method: Composition-based stats.
 Identities = 58/341 (17%), Positives = 112/341 (32%), Gaps = 78/341 (22%)

Query: 11  VYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEA-----INITNNEKV 65
            Y D         W++         ++     + LG G + +V EA     I       V
Sbjct: 23  SYIDPTQLPYDHKWEFP--------RNRLSFGKTLGAGAFGKVVEATAQGLIKSDAAMTV 74

Query: 66  VVKILKP----VKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDF 121
            VK+LKP     +++ +  E+K+L  L    NI+ L             ++ E+    D 
Sbjct: 75  AVKMLKPSAHSTEREALMSELKVLSYLGNHENIVNLLGACTH--GGPTLVITEYCCYGDL 132

Query: 122 KQLYQT-------------------LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNV 162
               +                    LT   +  + Y++ K + +  S   +HRD+   N+
Sbjct: 133 LNFLRRKRDEFVPYKVAPEDLYKDFLTLEHLLSFSYQVAKGMAFLASKNCIHRDLAARNI 192

Query: 163 MIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLG 219
           ++ H +   ++ D+GLA        Y  +  +R    +  PE + +  +Y +  D+WS G
Sbjct: 193 LLTHGNIT-KICDFGLARDIKNDSNYVDKGNARLPVKWMAPESIFN-SVYTFESDVWSYG 250

Query: 220 CMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRK 279
             L  +       + G     +  ++ K        +     + E  P            
Sbjct: 251 IFLWELFSLGSSPYPGMPVDSKFYKMIK--------EGFRMSSPEYAP------------ 290

Query: 280 RWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAME 320
                           E  D +      D   R T ++ ++
Sbjct: 291 ---------------AEMYDIMKTCWDADPDKRPTFKQIVQ 316


>5X02-A nrPDB
          Length = 347

 Score =  200 bits (508), Expect = 1e-51,   Method: Composition-based stats.
 Identities = 53/263 (20%), Positives = 102/263 (38%), Gaps = 50/263 (19%)

Query: 11  VYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINI---TNNE--KV 65
            Y D   +     W++         +++ +  + LG G + +V  A            +V
Sbjct: 30  FYVDFREYEYDLKWEFP--------RENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQV 81

Query: 66  VVKILKPV----KKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDF 121
            VK+LK      +++ +  E+K++  L    NI+ L       +S    L+FE+    D 
Sbjct: 82  AVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACT--LSGPIYLIFEYCCYGDL 139

Query: 122 KQLYQT--------------------------LTDYDIRFYMYEILKALDYCHSMGIMHR 155
               ++                          LT  D+  + Y++ K +++      +HR
Sbjct: 140 LNYLRSKREKFSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHR 199

Query: 156 DVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLVDYQMYDYS 212
           D+   NV++ H  + +++ D+GLA        Y VR  +R    +  PE L +  +Y   
Sbjct: 200 DLAARNVLVTH-GKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFE-GIYTIK 257

Query: 213 LDMWSLGCMLASMIFRKEPFFHG 235
            D+WS G +L  +       + G
Sbjct: 258 SDVWSYGILLWEIFSLGVNPYPG 280


>1ZXE-A nrPDB
          Length = 303

 Score =  200 bits (508), Expect = 1e-51,   Method: Composition-based stats.
 Identities = 67/319 (21%), Positives = 123/319 (38%), Gaps = 70/319 (21%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK--KIKREIKILENLRGGPNII 95
           D++ +  LG+G + +V +A N  ++    +K ++  ++K   I  E+ +L +L     ++
Sbjct: 7   DFEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRHTEEKLSTILSEVMLLASL-NHQYVV 65

Query: 96  TLADIVKD-----------PVSRTPALVFEHVNNTDFKQLYQTLTDYDIR----FYMYEI 140
                  +               T  +  E+  N     L  +      R        +I
Sbjct: 66  RYYAAWLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQRDEYWRLFRQI 125

Query: 141 LKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH---------------PG 185
           L+AL Y HS GI+HR++KP N+ ID E R +++ D+GLA+  H                 
Sbjct: 126 LEALSYIHSQGIIHRNLKPMNIFID-ESRNVKIGDFGLAKNVHRSLDILKLDSQNLPGSS 184

Query: 186 QEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRI 245
                 + +  +   E+L     Y+  +DM+SLG +   MI+   PF  G +  + L ++
Sbjct: 185 DNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMIY---PFSTGMERVNILKKL 241

Query: 246 AKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLL 305
             V             +IE  P F+D   +  +K                     +  L+
Sbjct: 242 RSV-------------SIEFPPDFDDNKMKVEKK--------------------IIRLLI 268

Query: 306 RYDHQSRLTAREAMEHPYF 324
            +D   R  AR  +   + 
Sbjct: 269 DHDPNKRPGARTLLNSGWL 287


>5O0Y-A nrPDB
          Length = 579

 Score =  199 bits (507), Expect = 1e-51,   Method: Composition-based stats.
 Identities = 63/316 (19%), Positives = 123/316 (38%), Gaps = 62/316 (19%)

Query: 50  YSEVFEAINITNNEKVVVKIL----------KPVKKKKIKREIKILENLRGGPNIITLAD 99
           +SEV++A ++T    V VKI           K    K   RE +I + L   P I+ L D
Sbjct: 297 FSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKEL-DHPRIVKLYD 355

Query: 100 IVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYCHSMG--IMH 154
                 + +   V E+    D     +    +++ + R  + +I+ AL Y + +   I+H
Sbjct: 356 YF-SLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIH 414

Query: 155 RDVKPHNVMI--DHEHRKLRLIDWGLAEFYHPGQEYNVRV--------ASRYFKGPELLV 204
            D+KP N+++       ++++ D+GL++        +V           + ++  PE  V
Sbjct: 415 YDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFV 474

Query: 205 ---DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKY 261
              +       +D+WS+G +    ++ ++PF H     D L     +  TE         
Sbjct: 475 VGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATE--------- 525

Query: 262 NIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEH 321
            ++  P+                       +V+PEA  F+ + L Y  + R+  ++    
Sbjct: 526 -VQFPPK----------------------PVVTPEAKAFIRRCLAYRKEDRIDVQQLACD 562

Query: 322 PYFYTVVKDQARMGSS 337
           PY    ++      S 
Sbjct: 563 PYLLPHIRKSVSTSSP 578


>4GS6-A nrPDB
          Length = 315

 Score =  199 bits (506), Expect = 2e-51,   Method: Composition-based stats.
 Identities = 58/320 (18%), Positives = 106/320 (33%), Gaps = 60/320 (18%)

Query: 40  QLVRKLGRGKYSEVFEAINITNNEKVVVKILKPV-KKKKIKREIKILENLRGGPNIITLA 98
           ++   +GRG +  V +A      + V +K ++   ++K    E++ L  +   PNI+ L 
Sbjct: 12  EVEEVVGRGAFGVVCKAKWRA--KDVAIKQIESESERKAFIVELRQLSRV-NHPNIVKLY 68

Query: 99  DIVKDPVSRTPALVFEHVNNTDFKQLYQ------TLTDYDIRFYMYEILKALDYCHSMG- 151
               +P      LV E+        +          T      +  +  + + Y HSM  
Sbjct: 69  GACLNP----VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQP 124

Query: 152 --IMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMY 209
             ++HRD+KP N+++      L++ D+G A              S  +  PE+      Y
Sbjct: 125 KALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQ--THMTNNKGSAAWMAPEVFEGSN-Y 181

Query: 210 DYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRF 269
               D++S G +L  +I R++PF                +G          +N    P  
Sbjct: 182 SEKCDVFSWGIILWEVITRRKPFDE--------------IGGPAFRIMWAVHNGTRPPLI 227

Query: 270 NDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTARE---AMEH--PYF 324
            ++                            + +    D   R +  E    M H   YF
Sbjct: 228 KNLPKPIES---------------------LMTRCWSKDPSQRPSMEEIVKIMTHLMRYF 266

Query: 325 YTVVKDQARMGSSSMPGGST 344
               +        S+P G  
Sbjct: 267 PGADEPLQYPCQHSLPPGED 286


>6DBN-A nrPDB
          Length = 316

 Score =  197 bits (502), Expect = 5e-51,   Method: Composition-based stats.
 Identities = 66/313 (21%), Positives = 118/313 (37%), Gaps = 38/313 (12%)

Query: 15  VNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAI----NITNNEKVVVKIL 70
           V+  +P    D       +  +     +R LG G + +V             E+V VK L
Sbjct: 18  VSEKKPATEVDPTHFEKRFLKR-----IRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSL 72

Query: 71  KPVK----KKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY- 125
           KP         +K+EI+IL NL    NI+    I  +       L+ E + +   K+   
Sbjct: 73  KPESGGNHIADLKKEIEILRNLYH-ENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLP 131

Query: 126 ---QTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFY 182
                +       Y  +I K +DY  S   +HRD+   NV+++ E  ++++ D+GL +  
Sbjct: 132 KNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESE-HQVKIGDFGLTKAI 190

Query: 183 HPGQEYNV----RVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDN 238
              +EY      R +  ++  PE L+  + Y  + D+WS G  L  ++           +
Sbjct: 191 ETDKEYYTVKDDRDSPVFWYAPECLMQSKFY-IASDVWSFGVTLHELLTYC------DSD 243

Query: 239 YDQLVRIAKVLGTEDLYDYIDKY--------NIELDPRFNDILGRHSRKRWERFVHSENQ 290
              +    K++G       + +          +   P   D + +  RK WE    +   
Sbjct: 244 SSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTS 303

Query: 291 HLVSPEALDFLDK 303
                E  + L K
Sbjct: 304 FQNLIEGFEALLK 316


>5HI2-A nrPDB
          Length = 283

 Score =  197 bits (500), Expect = 8e-51,   Method: Composition-based stats.
 Identities = 56/280 (20%), Positives = 113/280 (40%), Gaps = 23/280 (8%)

Query: 32  EWGNQD-DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRG 90
           +W   D    + +++G G +  V++      +  V VK+L P + +  K E+ +L   R 
Sbjct: 14  DWEIPDGQITVGQRIGSGSFGTVYKGKW---HGDVAVKMLTPQQLQAFKNEVGVLRKTRH 70

Query: 91  GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ----TLTDYDIRFYMYEILKALDY 146
             NI+        P     A+V +    +                 +     +  + +DY
Sbjct: 71  V-NILLFMGYSTKP---QLAIVTQWCEGSSLYHHLHASETKFEMKKLIDIARQTARGMDY 126

Query: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF---YHPGQEYNVRVASRYFKGPELL 203
            H+  I+HRD+K +N+ + HE   +++ D+GLA     +    ++     S  +  PE++
Sbjct: 127 LHAKSIIHRDLKSNNIFL-HEDNTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVI 185

Query: 204 --VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKY 261
              D   Y +  D+++ G +L  ++  + P +   +N DQ   I +++G   L   + K 
Sbjct: 186 RMQDSNPYSFQSDVYAFGIVLYELMTGQLP-YSNINNRDQ---IIEMVGRGSLSPDLSKV 241

Query: 262 NIELDPRFNDILGR-HSRKRWERFVHSENQHLVSPEALDF 300
                 R   ++     +KR ER         +   A + 
Sbjct: 242 RSNCPKRMKRLMAECLKKKRDERPSFPRILAEIEELAREL 281


>2DQ7-X nrPDB
          Length = 283

 Score =  197 bits (500), Expect = 1e-50,   Method: Composition-based stats.
 Identities = 49/271 (18%), Positives = 111/271 (40%), Gaps = 18/271 (6%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP--VKKKKIKREIKILENLRGGPN 93
           ++  QL+++LG G++ EV+       N KV +K LKP  +  +    E +I++ L+    
Sbjct: 8   RESLQLIKRLGNGQFGEVWMGTW-NGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDK- 65

Query: 94  IITLADIVKDPVSRTPALVFEHVNNTDFKQLY-----QTLTDYDIRFYMYEILKALDYCH 148
           ++ L  +V +       +V E++N             + L   ++     ++   + Y  
Sbjct: 66  LVQLYAVVSEEP---IYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIE 122

Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLVD 205
            M  +HRD++  N+++ +     ++ D+GLA       EY  R  +++   +  PE  + 
Sbjct: 123 RMNYIHRDLRSANILVGN-GLICKIADFGLARLIED-NEYTARQGAKFPIKWTAPEAAL- 179

Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIEL 265
           Y  +    D+WS G +L  ++ +    + G +N + L ++ +        D     +  +
Sbjct: 180 YGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELM 239

Query: 266 DPRFNDILGRHSRKRWERFVHSENQHLVSPE 296
              +           + +    +      P+
Sbjct: 240 IHCWKKDPEERPTFEYLQSFLEDYFTATEPQ 270


>2OGV-A nrPDB
          Length = 317

 Score =  196 bits (499), Expect = 1e-50,   Method: Composition-based stats.
 Identities = 52/252 (20%), Positives = 98/252 (38%), Gaps = 37/252 (14%)

Query: 9   ARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNE----- 63
           +  + D       E W++         +++ Q  + LG G + +V EA      +     
Sbjct: 18  SYTFIDPTQLPYNEKWEFP--------RNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVL 69

Query: 64  KVVVKILKPV----KKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNT 119
           KV VK+LK      +K+ +  E+KI+ +L    NI+ L             ++ E+    
Sbjct: 70  KVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTH--GGPVLVITEYCCYG 127

Query: 120 DFKQLYQT-------------LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDH 166
           D     +              L   D+  +  ++ + + +  S   +HRDV   NV++ +
Sbjct: 128 DLLNFLRRKAEADLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTN 187

Query: 167 EHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLA 223
                ++ D+GLA        Y V+  +R    +  PE + D  +Y    D+WS G +L 
Sbjct: 188 -GHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDC-VYTVQSDVWSYGILLW 245

Query: 224 SMIFRKEPFFHG 235
            +       + G
Sbjct: 246 EIFSLGLNPYPG 257


>3A4O-X nrPDB
          Length = 286

 Score =  196 bits (499), Expect = 1e-50,   Method: Composition-based stats.
 Identities = 49/277 (17%), Positives = 117/277 (42%), Gaps = 20/277 (7%)

Query: 22  EYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP--VKKKKIK 79
           + WD ++  +    ++  +LV++LG G++ EV+      N+ KV VK LKP  +  +   
Sbjct: 1   KPWDKDAWEIP---RESIKLVKRLGAGQFGEVWMGY-YNNSTKVAVKTLKPGTMSVQAFL 56

Query: 80  REIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ-----TLTDYDIR 134
            E  +++ L+    ++ L  +V         ++ E++         +      +    + 
Sbjct: 57  EEANLMKTLQHDK-LVRLYAVVTR--EEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLI 113

Query: 135 FYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVAS 194
            +  +I + + Y      +HRD++  NV++  E    ++ D+GLA       EY  R  +
Sbjct: 114 DFSAQIAEGMAYIERKNYIHRDLRAANVLV-SESLMCKIADFGLARVIED-NEYTAREGA 171

Query: 195 RY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGT 251
           ++   +  PE + ++  +    D+WS G +L  ++   +  + G  N D +  +++    
Sbjct: 172 KFPIKWTAPEAI-NFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRM 230

Query: 252 EDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSE 288
             + +  D+    +   + +         + + V  +
Sbjct: 231 PRVENCPDELYDIMKMCWKEKAEERPTFDYLQSVLDD 267


>2H8H-A nrPDB
          Length = 535

 Score =  196 bits (498), Expect = 2e-50,   Method: Composition-based stats.
 Identities = 56/307 (18%), Positives = 115/307 (37%), Gaps = 56/307 (18%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP--VKKKKIKREIKILENLRGGPN 93
           ++  +L  KLG+G + EV+          V +K LKP  +  +   +E ++++ LR    
Sbjct: 266 RESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEAFLQEAQVMKKLRHEK- 323

Query: 94  IITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ-----TLTDYDIRFYMYEILKALDYCH 148
           ++ L  +V +       +V E+++        +      L    +     +I   + Y  
Sbjct: 324 LVQLYAVVSEEP---IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVE 380

Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLVD 205
            M  +HRD++  N+++  E+   ++ D+GLA       EY  R  +++   +  PE  + 
Sbjct: 381 RMNYVHRDLRAANILVG-ENLVCKVADFGLARLIED-NEYTARQGAKFPIKWTAPEAAL- 437

Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIEL 265
           Y  +    D+WS G +L  +  +    + G  N + L ++ +             Y +  
Sbjct: 438 YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG------------YRMPC 485

Query: 266 DPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAR--EAMEHPY 323
            P   + L                         D + +  R + + R T    +A    Y
Sbjct: 486 PPECPESLH------------------------DLMCQCWRKEPEERPTFEYLQAFLEDY 521

Query: 324 FYTVVKD 330
           F +    
Sbjct: 522 FTSTEPQ 528


>3BEA-A nrPDB
          Length = 333

 Score =  196 bits (498), Expect = 2e-50,   Method: Composition-based stats.
 Identities = 53/256 (20%), Positives = 100/256 (39%), Gaps = 41/256 (16%)

Query: 9   ARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNE----- 63
           +  + D       E W++         +++ Q  + LG G + +V EA      +     
Sbjct: 26  SYTFIDPTQLPYNEKWEFP--------RNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVL 77

Query: 64  KVVVKILKPV----KKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNT 119
           KV VK+LK      +K+ +  E+KI+ +L    NI+ L             ++ E+    
Sbjct: 78  KVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTH--GGPVLVITEYCCYG 135

Query: 120 DFKQLYQ-----------------TLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNV 162
           D     +                 TL+  D+  +  ++ + + +  S   +HRDV   NV
Sbjct: 136 DLLNFLRRKSRVLETDPAFAIANSTLSTRDLLHFSSQVAQGMAFLASKNCIHRDVAARNV 195

Query: 163 MIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLG 219
           ++ +     ++ D+GLA        Y V+  +R    +  PE + D  +Y    D+WS G
Sbjct: 196 LLTN-GHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDC-VYTVQSDVWSYG 253

Query: 220 CMLASMIFRKEPFFHG 235
            +L  +       + G
Sbjct: 254 ILLWEIFSLGLNPYPG 269


>4AN9-A nrPDB
          Length = 301

 Score =  196 bits (498), Expect = 2e-50,   Method: Composition-based stats.
 Identities = 64/325 (19%), Positives = 122/325 (37%), Gaps = 52/325 (16%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKI----LKPVKKKKIKREIKILENLRGGP 92
           DD++ + +LG G    VF+  +  +   +  K+    +KP  + +I RE+++L      P
Sbjct: 9   DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHEC-NSP 67

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYC-H 148
            I+              ++  EH++     Q+ +    + +  +      ++K L Y   
Sbjct: 68  YIVGFYGAFYS--DGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLRE 125

Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQM 208
              IMHRDVKP N++++    +++L D+G++      +  N  V +R +  PE L     
Sbjct: 126 KHKIMHRDVKPSNILVNSRG-EIKLCDFGVSGQL-IDEMANEFVGTRSYMSPERLQGT-H 182

Query: 209 YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPR 268
           Y    D+WS+G  L  M   + P       ++ L  I                  E  P+
Sbjct: 183 YSVQSDIWSMGLSLVEMAVGRYP-RPPMAIFELLDYIVN----------------EPPPK 225

Query: 269 FNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVV 328
               +                    S E  DF++K L  +   R   ++ M H +     
Sbjct: 226 LPSAV-------------------FSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSD 266

Query: 329 KDQARMGSS--SMPGGSTPVSSANM 351
            ++        S  G + P +  + 
Sbjct: 267 AEEVDFAGWLCSTIGLNQPSTPTHA 291


>6F3F-A nrPDB
          Length = 455

 Score =  195 bits (497), Expect = 2e-50,   Method: Composition-based stats.
 Identities = 57/307 (18%), Positives = 115/307 (37%), Gaps = 56/307 (18%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP--VKKKKIKREIKILENLRGGPN 93
           ++  +L  KLG+G + EV+          V +K LKP  +  +   +E ++++ LR    
Sbjct: 186 RESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEAFLQEAQVMKKLRHEK- 243

Query: 94  IITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ-----TLTDYDIRFYMYEILKALDYCH 148
           ++ L  +V +       +V E++N        +      L    +     +I   + Y  
Sbjct: 244 LVQLYAVVSEEP---IYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVE 300

Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLVD 205
            M  +HRD++  N+++  E+   ++ D+GLA       EY  R  +++   +  PE  + 
Sbjct: 301 RMNYVHRDLRAANILVG-ENLVCKVADFGLARLIED-NEYTARQGAKFPIKWTAPEAAL- 357

Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIEL 265
           Y  +    D+WS G +L  +  +    + G  N + L ++ +             Y +  
Sbjct: 358 YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG------------YRMPC 405

Query: 266 DPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAR--EAMEHPY 323
            P   + L                         D + +  R + + R T    +A    Y
Sbjct: 406 PPECPESLH------------------------DLMCQCWRKEPEERPTFEYLQAFLEDY 441

Query: 324 FYTVVKD 330
           F +    
Sbjct: 442 FTSTEPQ 448


>6GVJ-A nrPDB
          Length = 429

 Score =  195 bits (497), Expect = 2e-50,   Method: Composition-based stats.
 Identities = 68/309 (22%), Positives = 118/309 (38%), Gaps = 63/309 (20%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKI-----KREIKILENLR-GGP 92
           Y +++++G G  S+VF+ +N    +   +K +   +         + EI  L  L+    
Sbjct: 146 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 204

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYCHS 149
            II L D   +   +   +V E   N D     +    +  ++ + Y   +L+A+   H 
Sbjct: 205 KIIRLYDY--EITDQYIYMVME-CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQ 261

Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE---YNVRVASRYFKGPELLVDY 206
            GI+H D+KP N +I      L+LID+G+A    P       + +V +  +  PE + D 
Sbjct: 262 HGIVHSDLKPANFLIV--DGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDM 319

Query: 207 QM----------YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYD 256
                            D+WSLGC+L  M + K PF                   + + +
Sbjct: 320 SSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF-------------------QQIIN 360

Query: 257 YIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAR 316
            I K +  +DP           K                +  D L   L+ D + R++  
Sbjct: 361 QISKLHAIIDPNHEIEFPDIPEK----------------DLQDVLKCCLKRDPKQRISIP 404

Query: 317 EAMEHPYFY 325
           E + HPY  
Sbjct: 405 ELLAHPYVQ 413


>2WTK-C nrPDB
          Length = 305

 Score =  195 bits (497), Expect = 2e-50,   Method: Composition-based stats.
 Identities = 72/331 (21%), Positives = 128/331 (38%), Gaps = 58/331 (17%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK-------PVKKKKIKREIKILENLRG 90
            Y +   LG G Y +V E ++     +  VKILK       P  +  +K+EI++L  LR 
Sbjct: 6   KYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRH 65

Query: 91  GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDY-----DIRFYMYEILKALD 145
             N+I L D++ +   +   +V E+      +++  ++ +          Y  +++  L+
Sbjct: 66  -KNVIQLVDVLYNEEKQKMYMVMEYCVCG-MQEMLDSVPEKRFPVCQAHGYFCQLIDGLE 123

Query: 146 YCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHP---GQEYNVRVASRYFKGPEL 202
           Y HS GI+H+D+KP N+++      L++   G+AE  HP            S  F+ PE+
Sbjct: 124 YLHSQGIVHKDIKPGNLLLTT-GGTLKISALGVAEALHPFAADDTCRTSQGSPAFQPPEI 182

Query: 203 LVDYQMY-DYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKY 261
                 +  + +D+WS G  L ++     PF  G + Y              L++ I K 
Sbjct: 183 ANGLDTFSGFKVDIWSAGVTLYNITTGLYPF-EGDNIY-------------KLFENIGKG 228

Query: 262 NIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEH 321
           +  +                             P   D L  +L Y+   R + R+  +H
Sbjct: 229 SYAIPGDCG------------------------PPLSDLLKGMLEYEPAKRFSIRQIRQH 264

Query: 322 PYFYTVVKDQARMGSSSMPGGSTPVSSANMM 352
            +F       A       P   T     +M 
Sbjct: 265 SWFRK-KHPPAEAPVPIPPSPDTKDRWRSMT 294


>3KRL-A nrPDB
          Length = 335

 Score =  195 bits (495), Expect = 3e-50,   Method: Composition-based stats.
 Identities = 52/258 (20%), Positives = 99/258 (38%), Gaps = 43/258 (16%)

Query: 9   ARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNE----- 63
           +  + D       E W++         +++ Q  + LG G + +V EA      +     
Sbjct: 26  SYTFIDPTQLPYNEKWEFP--------RNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVL 77

Query: 64  KVVVKILKPV----KKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNT 119
           KV VK+LK      +K+ +  E+KI+ +L    NI+ L             ++ E+    
Sbjct: 78  KVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTH--GGPVLVITEYCCYG 135

Query: 120 DFKQLYQT-------------------LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPH 160
           D     +                    L+  D+  +  ++ + + +  S   +HRDV   
Sbjct: 136 DLLNFLRRKRPPGLEYSYNPSHNPEEQLSSRDLLHFSSQVAQGMAFLASKNCIHRDVAAR 195

Query: 161 NVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWS 217
           NV++ +     ++ D+GLA        Y V+  +R    +  PE + D  +Y    D+WS
Sbjct: 196 NVLLTN-GHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDC-VYTVQSDVWS 253

Query: 218 LGCMLASMIFRKEPFFHG 235
            G +L  +       + G
Sbjct: 254 YGILLWEIFSLGLNPYPG 271


>3DLS-A nrPDB
          Length = 335

 Score =  195 bits (495), Expect = 3e-50,   Method: Composition-based stats.
 Identities = 76/369 (20%), Positives = 133/369 (36%), Gaps = 70/369 (18%)

Query: 18  HRPREYWDYES-HVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK- 75
             P +  + E     E      Y  +  LG G +  V+ A++   N++VVVK +K  K  
Sbjct: 4   EEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVL 63

Query: 76  ----------KKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFE-HVNNTD---F 121
                      K+  EI IL  +    NII + DI ++       LV E H +  D   F
Sbjct: 64  EDCWIEDPKLGKVTLEIAILSRVEHA-NIIKVLDIFENQGFFQ--LVMEKHGSGLDLFAF 120

Query: 122 KQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF 181
              +  L +    +   +++ A+ Y     I+HRD+K  N++I  E   ++LID+G A +
Sbjct: 121 IDRHPRLDEPLASYIFRQLVSAVGYLRLKDIIHRDIKDENIVI-AEDFTIKLIDFGSAAY 179

Query: 182 YHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQ 241
              G+ +     +  +  PE+L+        L+MWSLG  L +++F + PF    +  + 
Sbjct: 180 LERGKLFYTFCGTIEYCAPEVLMGNPYRGPELEMWSLGVTLYTLVFEENPFCELEETVE- 238

Query: 242 LVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFL 301
                                                            +LVS E +  +
Sbjct: 239 -------------------------------------------AAIHPPYLVSKELMSLV 255

Query: 302 DKLLRYDHQSRLTAREAMEHPY------FYTVVKDQARMGSSSMPGGSTPVSSANMMSGI 355
             LL+   + R T  + +  P+            ++    +    G  +  S       +
Sbjct: 256 SGLLQPVPERRTTLEKLVTDPWVTQPVNLADYTWEEVFRVNKPESGVLSAASLEMGNRSL 315

Query: 356 SSVPTPSPL 364
           S V     L
Sbjct: 316 SDVAQAQEL 324


>4XUF-A nrPDB
          Length = 297

 Score =  195 bits (495), Expect = 3e-50,   Method: Composition-based stats.
 Identities = 51/244 (20%), Positives = 99/244 (40%), Gaps = 43/244 (17%)

Query: 31  VEWG-NQDDYQLVRKLGRGKYSEVFEAINI---TNNE--KVVVKILKPV----KKKKIKR 80
           ++W   +++ +  + LG G + +V  A            +V VK+LK      +++ +  
Sbjct: 2   LKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMS 61

Query: 81  EIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT------------- 127
           E+K++  L    NI+ L       +S    L+FE+    D     ++             
Sbjct: 62  ELKMMTQLGSHENIVNLLGACT--LSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYE 119

Query: 128 -------------LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLI 174
                        LT  D+  + Y++ K +++      +HRD+   NV++ H  + +++ 
Sbjct: 120 NQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTH-GKVVKIC 178

Query: 175 DWGLAEFYHPGQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEP 231
           D+GLA        Y VR  +R    +  PE L +  +Y    D+WS G +L  +      
Sbjct: 179 DFGLARDIMSDSNYVVRGNARLPVKWMAPESLFE-GIYTIKSDVWSYGILLWEIFSLGVN 237

Query: 232 FFHG 235
            + G
Sbjct: 238 PYPG 241


>3G0E-A nrPDB
          Length = 336

 Score =  194 bits (494), Expect = 4e-50,   Method: Composition-based stats.
 Identities = 61/343 (17%), Positives = 114/343 (33%), Gaps = 80/343 (23%)

Query: 11  VYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEA-----INITNNEKV 65
           VY D         W++         ++     + LG G + +V EA     I       V
Sbjct: 28  VYIDPTQLPYDHKWEFP--------RNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTV 79

Query: 66  VVKILKP----VKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDF 121
            VK+LKP     +++ +  E+K+L  L    NI+ L       +     ++ E+    D 
Sbjct: 80  AVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACT--IGGPTLVITEYCCYGDL 137

Query: 122 KQLYQTLTDYDI---------------------RFYMYEILKALDYCHSMGIMHRDVKPH 160
               +   D  I                       + Y++ K + +  S   +HRD+   
Sbjct: 138 LNFLRRKRDSFICSKTSPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAAR 197

Query: 161 NVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWS 217
           N+++ H  R  ++ D+GLA        Y V+  +R    +  PE + +  +Y +  D+WS
Sbjct: 198 NILLTH-GRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNC-VYTFESDVWS 255

Query: 218 LGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHS 277
            G  L  +       + G     +  ++ K        +     + E  P          
Sbjct: 256 YGIFLWELFSLGSSPYPGMPVDSKFYKMIK--------EGFRMLSPEHAP---------- 297

Query: 278 RKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAME 320
                             E  D +      D   R T ++ ++
Sbjct: 298 -----------------AEMYDIMKTCWDADPLKRPTFKQIVQ 323


>3CJF-A nrPDB
          Length = 309

 Score =  194 bits (494), Expect = 5e-50,   Method: Composition-based stats.
 Identities = 65/338 (19%), Positives = 127/338 (37%), Gaps = 69/338 (20%)

Query: 14  DVNTHRPREYWD---YESHVVEWGNQDDYQLVRKLGRGKYSEVFEA----INIT-NNEKV 65
           D +     E+ +   Y++   E+  +D   L + LGRG + +V EA    I+ T     V
Sbjct: 2   DPDELPLDEHCERLPYDASKWEF-PRDRLNLGKPLGRGAFGQVIEADAFGIDKTATCRTV 60

Query: 66  VVKILKP----VKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDF 121
            VK+LK      + + +  E+KIL ++    N++ L      P      +V E     + 
Sbjct: 61  AVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIV-EFCKFGNL 119

Query: 122 KQLYQT---------------LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDH 166
               ++               LT   +  Y +++ K +++  S   +HRD+   N+++  
Sbjct: 120 STYLRSKRNEFVPYKDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSE 179

Query: 167 EHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLA 223
           ++  +++ D+GLA   +   +Y  +  +R    +  PE + D ++Y    D+WS G +L 
Sbjct: 180 KN-VVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFD-RVYTIQSDVWSFGVLLW 237

Query: 224 SMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWER 283
            +       + G                           +++D  F   L   +R R   
Sbjct: 238 EIFSLGASPYPG---------------------------VKIDEEFCRRLKEGTRMRAPD 270

Query: 284 FVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEH 321
           +   E    +              +   R T  E +EH
Sbjct: 271 YTTPEMYQTMLD--------CWHGEPSQRPTFSELVEH 300


>5H2U-A nrPDB
          Length = 267

 Score =  194 bits (494), Expect = 5e-50,   Method: Composition-based stats.
 Identities = 54/262 (20%), Positives = 109/262 (41%), Gaps = 25/262 (9%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK---KKKIKREIKILENLRGGP 92
           ++++ L RKLG G + EVFE +   +  +V +K++       ++ ++ EI+ ++ LR   
Sbjct: 5   REEFTLCRKLGSGYFGEVFEGLWK-DRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRH-K 62

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ-----TLTDYDIRFYMYEILKALDYC 147
           +I+ L  +V   V     ++ E +      +L +      L   ++    +++ + + Y 
Sbjct: 63  HILALYAVV--SVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYL 120

Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY-FKGPELLVDY 206
            S   +HRD+   N+++  E+   ++ D+GLA         +      Y +  PE L   
Sbjct: 121 ESQNYIHRDLAARNILVG-ENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEAL-SR 178

Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYN---- 262
             Y    D+WS G +L  M  R +  + G  N++  +R+          +     +    
Sbjct: 179 GHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLML 238

Query: 263 ------IELDPRFNDILGRHSR 278
                  E  P F  +  R S 
Sbjct: 239 TCWCRDPEQRPTFKALRERLSS 260


>2XYN-A nrPDB
          Length = 292

 Score =  194 bits (493), Expect = 6e-50,   Method: Composition-based stats.
 Identities = 52/274 (18%), Positives = 115/274 (41%), Gaps = 33/274 (12%)

Query: 25  DYESHVVEWGNQDDYQLVR-------KLGRGKYSEVFEAINITNNEKVVVKILK--PVKK 75
           D  +  + + + D +++ R       KLG G+Y EV+  +    +  V VK LK   ++ 
Sbjct: 13  DLGTENLYFQSMDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEV 72

Query: 76  KKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDI-- 133
           ++  +E  +++ ++  PN++ L  +    +     +V E++   +     +     ++  
Sbjct: 73  EEFLKEAAVMKEIKH-PNLVQLLGVCT--LEPPFYIVTEYMPYGNLLDYLRECNREEVTA 129

Query: 134 ---RFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNV 190
               +   +I  A++Y      +HRD+   N ++  E+  +++ D+GL+     G  Y  
Sbjct: 130 VVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVG-ENHVVKVADFGLSRLM-TGDTYTA 187

Query: 191 RVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHD---NYDQLVR 244
              +++   +  PE L  Y  +    D+W+ G +L  +       + G D    YD L +
Sbjct: 188 HAGAKFPIKWTAPESLA-YNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEK 246

Query: 245 IAKVLGTE-------DLYDYIDKYNIELDPRFND 271
             ++   E       +L     K++    P F +
Sbjct: 247 GYRMEQPEGCPPKVYELMRACWKWSPADRPSFAE 280


>3HMP-A nrPDB
          Length = 342

 Score =  194 bits (492), Expect = 7e-50,   Method: Composition-based stats.
 Identities = 68/309 (22%), Positives = 118/309 (38%), Gaps = 63/309 (20%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKI-----KREIKILENLR-GGP 92
           Y +++++G G  S+VF+ +N    +   +K +   +         + EI  L  L+    
Sbjct: 58  YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 116

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYCHS 149
            II L D   +   +   +V E   N D     +    +  ++ + Y   +L+A+   H 
Sbjct: 117 KIIRLYDY--EITDQYIYMVME-CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQ 173

Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE---YNVRVASRYFKGPELLVDY 206
            GI+H D+KP N +I      L+LID+G+A    P       + +V +  +  PE + D 
Sbjct: 174 HGIVHSDLKPANFLIV--DGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDM 231

Query: 207 QM----------YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYD 256
                            D+WSLGC+L  M + K PF                   + + +
Sbjct: 232 SSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF-------------------QQIIN 272

Query: 257 YIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAR 316
            I K +  +DP           K                +  D L   L+ D + R++  
Sbjct: 273 QISKLHAIIDPNHEIEFPDIPEK----------------DLQDVLKCCLKRDPKQRISIP 316

Query: 317 EAMEHPYFY 325
           E + HPY  
Sbjct: 317 ELLAHPYVQ 325


>1S9I-A nrPDB
          Length = 354

 Score =  194 bits (492), Expect = 7e-50,   Method: Composition-based stats.
 Identities = 59/314 (18%), Positives = 118/314 (37%), Gaps = 24/314 (7%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKI----LKPVKKKKIKREIKILENLRGGP 92
           DD++ + +LG G    V +  +  +   +  K+    +KP  + +I RE+++L      P
Sbjct: 16  DDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHEC-NSP 74

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYC-H 148
            I+              ++  EH++     Q+    + + +  +      +L+ L Y   
Sbjct: 75  YIVGFYGAFYS--DGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLRE 132

Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQM 208
              IMHRDVKP N++++    +++L D+G++         N  V +R +  PE L     
Sbjct: 133 KHQIMHRDVKPSNILVNSRG-EIKLCDFGVSGQLIDSMA-NSFVGTRSYMAPERLQGT-H 189

Query: 209 YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPR 268
           Y    D+WS+G  L  +   + P         + +    V+  E+   +          R
Sbjct: 190 YSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRPPGR 249

Query: 269 FNDILGRHSRKRWERF----------VHSENQHLVSPEALDFLDKLLRYDHQSRLTAREA 318
                G  SR     F                 + +P+  +F++K L  +   R   +  
Sbjct: 250 PVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADLKML 309

Query: 319 MEHPYFYTVVKDQA 332
             H +      ++ 
Sbjct: 310 TNHTFIKRSEVEEV 323


>5SYS-A nrPDB
          Length = 286

 Score =  194 bits (492), Expect = 7e-50,   Method: Composition-based stats.
 Identities = 56/307 (18%), Positives = 114/307 (37%), Gaps = 56/307 (18%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP--VKKKKIKREIKILENLRGGPN 93
           ++  +L  KLG+G + E +          V +K LKP  +  +   +E ++++ LR    
Sbjct: 17  RESLRLEVKLGQGCFGECWMGTWNGTTR-VAIKTLKPGTMSPEAFLQEAQVMKKLRHEK- 74

Query: 94  IITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ-----TLTDYDIRFYMYEILKALDYCH 148
           ++ L  +V +       +V E+++        +      L    +     +I   + Y  
Sbjct: 75  LVQLYAVVSEEP---IYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVE 131

Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLVD 205
            M  +HRD++  N+++  E+   ++ D+GLA       EY  R  +++   +  PE  + 
Sbjct: 132 RMNYVHRDLRAANILVG-ENLVCKVADFGLARLIED-NEYTARQGAKFPIKWTAPEAAL- 188

Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIEL 265
           Y  +    D+WS G +L  +  +    + G  N + L ++ +             Y +  
Sbjct: 189 YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG------------YRMPC 236

Query: 266 DPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAR--EAMEHPY 323
            P   + L                         D + +  R D + R T    +A    Y
Sbjct: 237 PPECPESLH------------------------DLMCQCWRKDPEERPTFEYLQAFLEDY 272

Query: 324 FYTVVKD 330
           F +    
Sbjct: 273 FTSTEPQ 279


>3OMV-A nrPDB
          Length = 307

 Score =  194 bits (492), Expect = 7e-50,   Method: Composition-based stats.
 Identities = 55/285 (19%), Positives = 112/285 (39%), Gaps = 36/285 (12%)

Query: 16  NTHRPRE------YWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKI 69
           N  RPR       YW+ E+  V    +        +G G +  V++      +  V VKI
Sbjct: 17  NKIRPRGQRDSSYYWEIEASEVMLSTR--------IGSGSFGTVYKGKW---HGDVAVKI 65

Query: 70  LK-----PVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQL 124
           LK     P + +  + E+ +L   R   NI+              A+V +    +   + 
Sbjct: 66  LKVVDPTPEQFQAFRNEVAVLRKTRHV-NILLFMGY---MTKDNLAIVTQWCEGSSLYKH 121

Query: 125 YQ----TLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE 180
                     + +     +  + +DY H+  I+HRD+K +N+ + HE   +++ D+GLA 
Sbjct: 122 LHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFL-HEGLTVKIGDFGLAT 180

Query: 181 F---YHPGQEYNVRVASRYFKGPELL--VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHG 235
               +   Q+      S  +  PE++   D   + +  D++S G +L  ++  + P+ H 
Sbjct: 181 VKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHI 240

Query: 236 HDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKR 280
           ++    +  + +   + DL          +     D + +   +R
Sbjct: 241 NNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEER 285


>2VWV-A nrPDB
          Length = 302

 Score =  193 bits (491), Expect = 9e-50,   Method: Composition-based stats.
 Identities = 63/323 (19%), Positives = 122/323 (37%), Gaps = 44/323 (13%)

Query: 25  DYESHVVEWGNQDDY---QLVRKLGRGKYSEVFEAINITNNEK---VVVKILK----PVK 74
           D    V E+  + D    ++   +G G++ EV         +K   V +K LK      +
Sbjct: 1   DPNEAVREFAKEIDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQ 60

Query: 75  KKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ----TLTD 130
           +++   E  I+      PNII L  +V +  S    ++ E + N       +      T 
Sbjct: 61  RREFLSEASIMGQFEH-PNIIRLEGVVTN--SMPVMILTEFMENGALDSFLRLNDGQFTV 117

Query: 131 YDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHP---GQE 187
             +   +  I   + Y   M  +HRD+   N++++  +   ++ D+GL+ F         
Sbjct: 118 IQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNS-NLVCKVSDFGLSRFLEENSSDPT 176

Query: 188 YNVRVASR---YFKGPELLVDYQMYDYSLDMWSLGCMLAS-MIFRKEPFFHGHDNYDQLV 243
               +  +    +  PE +  ++ +  + D WS G ++   M F + P++    N D + 
Sbjct: 177 ETSSLGGKIPIRWTAPEAIA-FRKFTSASDAWSYGIVMWEVMSFGERPYWD-MSNQDVIN 234

Query: 244 RIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDK 303
            I +             Y +   P     L +     W++     N     P+ +  LDK
Sbjct: 235 AIEQ------------DYRLPPPPDCPTSLHQLMLDCWQK---DRNARPRFPQVVSALDK 279

Query: 304 LLRYDHQSRLTARE--AMEHPYF 324
           ++R     ++ ARE     HP  
Sbjct: 280 MIRNPASLKIVARENGGASHPLL 302


>3BGP-A nrPDB
          Length = 333

 Score =  193 bits (491), Expect = 1e-49,   Method: Composition-based stats.
 Identities = 68/311 (21%), Positives = 120/311 (38%), Gaps = 61/311 (19%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK---------KIKREIKILE 86
           +  YQ+   LG G +  V+  I +++N  V +K ++  +           ++  E+ +L+
Sbjct: 55  ESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLK 114

Query: 87  NLRGG-PNIITLADIVKDPVSRTPALVFEHVNNT----DFKQLYQTLTDYDIRFYMYEIL 141
            +  G   +I L D  + P S    L+ E         DF      L +   R + +++L
Sbjct: 115 KVSSGFSGVIRLLDWFERPDSF--VLILERPEPVQDLFDFITERGALQEELARSFFWQVL 172

Query: 142 KALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPE 201
           +A+ +CH+ G++HRD+K  N++ID    +L+LID+G          Y     +R +  PE
Sbjct: 173 EAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKD-TVYTDFDGTRVYSPPE 231

Query: 202 LLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKY 261
            +  ++ +  S  +WSLG +L  M+    PF H  +                    I + 
Sbjct: 232 WIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE--------------------IIRG 271

Query: 262 NIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEH 321
            +    R                        VS E    +   L      R T  E   H
Sbjct: 272 QVFFRQR------------------------VSSECQHLIRWCLALRPSDRPTFEEIQNH 307

Query: 322 PYFYTVVKDQA 332
           P+   V+  Q 
Sbjct: 308 PWMQDVLLPQE 318


>3IO7-A nrPDB
          Length = 313

 Score =  193 bits (490), Expect = 1e-49,   Method: Composition-based stats.
 Identities = 46/216 (21%), Positives = 98/216 (45%), Gaps = 18/216 (8%)

Query: 27  ESHVVEWGNQDDYQLVRKLGRGKYSEVFEAI----NITNNEKVVVKILKPVKKK---KIK 79
            SH +    +   + +++LG+G +  V             E V VK L+   ++     +
Sbjct: 18  GSHNMTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFE 77

Query: 80  REIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDY----DIRF 135
           REI+IL++L+   NI+    +      R   L+ E++     +   Q   +      +  
Sbjct: 78  REIEILKSLQHD-NIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQ 136

Query: 136 YMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVR---- 191
           Y  +I K ++Y  +   +HRD+   N+++++E+R +++ D+GL +     +EY       
Sbjct: 137 YTSQICKGMEYLGTKRYIHRDLATRNILVENENR-VKIGDFGLTKVLPQDKEYYKVKEPG 195

Query: 192 VASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIF 227
            +  ++  PE L + + +  + D+WS G +L  +  
Sbjct: 196 ESPIFWYAPESLTESK-FSVASDVWSFGVVLYELFT 230


>2R2P-A nrPDB
          Length = 295

 Score =  193 bits (490), Expect = 1e-49,   Method: Composition-based stats.
 Identities = 63/310 (20%), Positives = 120/310 (38%), Gaps = 41/310 (13%)

Query: 20  PREYWDYESHVVEWGNQDD---YQLVRKLGRGKYSEVFEAINITNNEK---VVVKILKPV 73
           P  Y D    V E+  + +     + R +G G++ EV         ++   V +K LK  
Sbjct: 2   PHTYEDPNQAVHEFAKEIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVG 61

Query: 74  KKKKIKR----EIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT-- 127
             +K +R    E  I+      PNII L  +V    S+   +V E++ N       +   
Sbjct: 62  YTEKQRRDFLGEASIMGQF-DHPNIIHLEGVVT--KSKPVMIVTEYMENGSLDTFLKKND 118

Query: 128 --LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPG 185
              T   +   +  I   + Y   MG +HRD+   N++I+  +   ++ D+GL+      
Sbjct: 119 GQFTVIQLVGMLRGISAGMKYLSDMGYVHRDLAARNILINS-NLVCKVSDFGLSRVLEDD 177

Query: 186 QE--YNVRVA--SRYFKGPELLVDYQMYDYSLDMWSLGCMLASMI-FRKEPFFHGHDNYD 240
            E  Y  R       +  PE +  ++ +  + D+WS G ++  ++ + + P++    N D
Sbjct: 178 PEAAYTTRGGKIPIRWTAPEAIA-FRKFTSASDVWSYGIVMWEVVSYGERPYWE-MTNQD 235

Query: 241 QLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDF 300
            +  + +        D                L +     W++     N      E ++ 
Sbjct: 236 VIKAVEEGYRLPSPMD------------CPAALYQLMLDCWQK---ERNSRPKFDEIVNM 280

Query: 301 LDKLLRYDHQ 310
           LDKL+R +  
Sbjct: 281 LDKLIR-NPA 289


>5AP3-A nrPDB
          Length = 313

 Score =  192 bits (489), Expect = 2e-49,   Method: Composition-based stats.
 Identities = 68/309 (22%), Positives = 118/309 (38%), Gaps = 63/309 (20%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKI-----KREIKILENLR-GGP 92
           Y +++++G G  S+VF+ +N    +   +K +   +         + EI  L  L+    
Sbjct: 30  YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 88

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYCHS 149
            II L D   +   +   +V E   N D     +    +  ++ + Y   +L+A+   H 
Sbjct: 89  KIIRLYDY--EITDQYIYMVME-CGNIDLNGWLKKKKSIDPWERKSYWKNMLEAVHTIHQ 145

Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE---YNVRVASRYFKGPELLVDY 206
            GI+H D+KP N +I      L+LID+G+A    P       + +V +  +  PE + D 
Sbjct: 146 HGIVHSDLKPANFLIV--DGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDM 203

Query: 207 QM----------YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYD 256
                            D+WSLGC+L  M + K PF                   + + +
Sbjct: 204 SSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF-------------------QQIIN 244

Query: 257 YIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAR 316
            I K +  +DP           K                +  D L   L+ D + R++  
Sbjct: 245 QISKLHAIIDPNHEIEFPDIPEK----------------DLQDVLKCCLKRDPKQRISIP 288

Query: 317 EAMEHPYFY 325
           E + HPY  
Sbjct: 289 ELLAHPYVQ 297


>4EQM-A nrPDB
          Length = 294

 Score =  192 bits (489), Expect = 2e-49,   Method: Composition-based stats.
 Identities = 67/293 (22%), Positives = 130/293 (44%), Gaps = 27/293 (9%)

Query: 27  ESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL------KPVKKKKIKR 80
            SH++     + Y++V KLG G  S V+ A +   N KV +K +      K    K+ +R
Sbjct: 1   GSHMIGKIINERYKIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETLKRFER 60

Query: 81  EIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYM 137
           E+     L    NI+++ D+  D       LV E++      +  ++   L+      + 
Sbjct: 61  EVHNSSQLSHQ-NIVSMIDV--DEEDDCYYLVMEYIEGPTLSEYIESHGPLSVDTAINFT 117

Query: 138 YEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ--EYNVRVASR 195
            +IL  + + H M I+HRD+KP N++ID  ++ L++ D+G+A+        + N  + + 
Sbjct: 118 NQILDGIKHAHDMRIVHRDIKPQNILIDS-NKTLKIFDFGIAKALSETSLTQTNHVLGTV 176

Query: 196 YFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLY 255
            +  PE     +  D   D++S+G +L  M+  + PF     N +  V IA     + + 
Sbjct: 177 QYFSPE-QAKGEATDECTDIYSIGIVLYEMLVGEPPF-----NGETAVSIAIKHIQDSVP 230

Query: 256 DYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYD 308
           +       ++    ++++ R + K         N++    E  D L  +L  +
Sbjct: 231 NVTTDVRKDIPQSLSNVILRATEKD------KANRYKTIQEMKDDLSSVLHEN 277


>4RC3-A nrPDB
          Length = 289

 Score =  192 bits (488), Expect = 2e-49,   Method: Composition-based stats.
 Identities = 68/311 (21%), Positives = 120/311 (38%), Gaps = 61/311 (19%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK---------KIKREIKILE 86
           +  YQ+   LG G +  V+  I +++N  V +K ++  +           ++  E+ +L+
Sbjct: 11  ESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLK 70

Query: 87  NLRGG-PNIITLADIVKDPVSRTPALVFEHVNNT----DFKQLYQTLTDYDIRFYMYEIL 141
            +  G   +I L D  + P S    L+ E         DF      L +   R + +++L
Sbjct: 71  KVSSGFSGVIRLLDWFERPDSF--VLILERPEPVQDLFDFITERGALQEELARSFFWQVL 128

Query: 142 KALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPE 201
           +A+ +CH+ G++HRD+K  N++ID    +L+LID+G          Y     +R +  PE
Sbjct: 129 EAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKD-TVYTDFDGTRVYSPPE 187

Query: 202 LLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKY 261
            +  ++ +  S  +WSLG +L  M+    PF H  +                    I + 
Sbjct: 188 WIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE--------------------IIRG 227

Query: 262 NIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEH 321
            +    R                        VS E    +   L      R T  E   H
Sbjct: 228 QVFFRQR------------------------VSSECQHLIRWCLALRPSDRPTFEEIQNH 263

Query: 322 PYFYTVVKDQA 332
           P+   V+  Q 
Sbjct: 264 PWMQDVLLPQE 274


>4IAN-A nrPDB
          Length = 358

 Score =  192 bits (488), Expect = 2e-49,   Method: Composition-based stats.
 Identities = 69/326 (21%), Positives = 133/326 (40%), Gaps = 43/326 (13%)

Query: 38  DYQLVRKLGRGKYSEVFEAINI-TNNEKVVVKILKPVK--KKKIKREIKILENLRGGP-- 92
            Y +    G+G +S V  A +    N++V VKI++  +  +K   +E++ L+ L      
Sbjct: 31  RYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTGLKELEFLKKLNDADPD 90

Query: 93  ---NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT------LTDYDIRFYMYEILKA 143
              + + L         +   LVFE ++  + +++ +       L    +R Y  ++  A
Sbjct: 91  DKFHCLRLFRHFYHK--QHLCLVFEPLS-MNLREVLKKYGKDVGLHIKAVRSYSQQLFLA 147

Query: 144 LDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELL 203
           L       I+H D+KP N++++     L+L D+G A            + SR+++ PE++
Sbjct: 148 LKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASHVADND-ITPYLVSRFYRAPEII 206

Query: 204 VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTED---------- 253
           +  + YDY +DMWS+GC L  +   K   F G  N   L     + G             
Sbjct: 207 IG-KSYDYGIDMWSVGCTLYELYTGKI-LFPGKTNNHMLKLAMDLKGKMPNKMIRKGVFK 264

Query: 254 --------LYDYIDKYNIELDPRFNDILGRHSRKRWERFV-----HSENQHLVSPEALDF 300
                    + YI+   +    +   +   +  K     +       E+Q     +  D 
Sbjct: 265 DQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLADLIGCQRLPEDQRKKVHQLKDL 324

Query: 301 LDKLLRYDHQSRLTAREAMEHPYFYT 326
           LD++L  D   R++  +A++H +   
Sbjct: 325 LDQILMLDPAKRISINQALQHAFIQE 350


>2ZMD-A nrPDB
          Length = 390

 Score =  192 bits (487), Expect = 3e-49,   Method: Composition-based stats.
 Identities = 68/309 (22%), Positives = 118/309 (38%), Gaps = 63/309 (20%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKI-----KREIKILENLR-GGP 92
           Y +++++G G  S+VF+ +N    +   +K +   +         + EI  L  L+    
Sbjct: 58  YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 116

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYCHS 149
            II L D   +   +   +V E   N D     +    +  ++ + Y   +L+A+   H 
Sbjct: 117 KIIRLYDY--EITDQYIYMVME-CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQ 173

Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE---YNVRVASRYFKGPELLVDY 206
            GI+H D+KP N +I      L+LID+G+A    P       + +V +  +  PE + D 
Sbjct: 174 HGIVHSDLKPANFLIV--DGMLKLIDFGIANQMQPDTTSVVKDSQVGAVNYMPPEAIKDM 231

Query: 207 QM----------YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYD 256
                            D+WSLGC+L  M + K PF                   + + +
Sbjct: 232 SSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF-------------------QQIIN 272

Query: 257 YIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAR 316
            I K +  +DP           K                +  D L   L+ D + R++  
Sbjct: 273 QISKLHAIIDPNHEIEFPDIPEK----------------DLQDVLKCCLKRDPKQRISIP 316

Query: 317 EAMEHPYFY 325
           E + HPY  
Sbjct: 317 ELLAHPYVQ 325


>4XEY-B nrPDB
          Length = 408

 Score =  192 bits (487), Expect = 3e-49,   Method: Composition-based stats.
 Identities = 56/343 (16%), Positives = 126/343 (36%), Gaps = 63/343 (18%)

Query: 4   PVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNE 63
           P P R +      +    + W+ E        + D  +  KLG G+Y EV+E +    + 
Sbjct: 101 PAPKRNKPTVYGVSPN-YDKWEME--------RTDITMKHKLGGGQYGEVYEGVWKKYSL 151

Query: 64  KVVVKILK--PVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDF 121
            V VK LK   ++ ++  +E  +++ ++  PN++ L  +          ++ E +   + 
Sbjct: 152 TVAVKTLKEDTMEVEEFLKEAAVMKEIKH-PNLVQLLGVCTREP--PFYIITEFMTYGNL 208

Query: 122 KQLYQTLTDYDI-----RFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDW 176
               +     ++      +   +I  A++Y      +HRD+   N ++  E+  +++ D+
Sbjct: 209 LDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVG-ENHLVKVADF 267

Query: 177 GLAEFYHPGQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFF 233
           GL+     G  Y     +++   +  PE L  Y  +    D+W+ G +L  +       +
Sbjct: 268 GLSRLM-TGDTYTAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSPY 325

Query: 234 HGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLV 293
            G D    L ++ ++L                                E+    E     
Sbjct: 326 PGID----LSQVYELL--------------------------------EKDYRMERPEGC 349

Query: 294 SPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGS 336
             +  + +    +++   R +  E   H  F T+ ++ +    
Sbjct: 350 PEKVYELMRACWQWNPSDRPSFAEI--HQAFETMFQESSISDE 390


>5HIE-A nrPDB
          Length = 302

 Score =  192 bits (487), Expect = 3e-49,   Method: Composition-based stats.
 Identities = 50/279 (17%), Positives = 110/279 (39%), Gaps = 21/279 (7%)

Query: 32  EWGNQD-DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRG 90
           +W   D    + +++G G +  V++      +  V VK+L P + +  K E+ +L   R 
Sbjct: 30  DWEIPDGQITVGQRIGSGSFGTVYKGKW---HGDVAVKMLTPQQLQAFKNEVGVLRKTRH 86

Query: 91  GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ----TLTDYDIRFYMYEILKALDY 146
             NI+        P     A+V +    +                 +     +  + +DY
Sbjct: 87  V-NILLFMGYSTKP---QLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDY 142

Query: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF---YHPGQEYNVRVASRYFKGPELL 203
            H+  I+HRD+K +N+ + HE   +++ D+GLA     +    ++     S  +  PE++
Sbjct: 143 LHAKSIIHRDLKSNNIFL-HEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVI 201

Query: 204 --VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKY 261
              D   Y +  D+++ G +L  ++  + P+ + ++    +  + +   + DL       
Sbjct: 202 RMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNC 261

Query: 262 NIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDF 300
              +      +     +KR ER +  +    +   A   
Sbjct: 262 PKAMK---RLMAECLKKKRDERPLFPQILASIELLARSL 297


>5TUR-A nrPDB
          Length = 404

 Score =  192 bits (487), Expect = 3e-49,   Method: Composition-based stats.
 Identities = 68/311 (21%), Positives = 120/311 (38%), Gaps = 61/311 (19%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK---------KIKREIKILE 86
           +  YQ+   LG G +  V+  I +++N  V +K ++  +           ++  E+ +L+
Sbjct: 126 ESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLK 185

Query: 87  NLRGG-PNIITLADIVKDPVSRTPALVFEHVNNT----DFKQLYQTLTDYDIRFYMYEIL 141
            +  G   +I L D  + P S    L+ E         DF      L +   R + +++L
Sbjct: 186 KVSSGFSGVIRLLDWFERPDSF--VLILERPEPVQDLFDFITERGALQEELARSFFWQVL 243

Query: 142 KALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPE 201
           +A+ +CH+ G++HRD+K  N++ID    +L+LID+G          Y     +R +  PE
Sbjct: 244 EAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKD-TVYTDFDGTRVYSPPE 302

Query: 202 LLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKY 261
            +  ++ +  S  +WSLG +L  M+    PF H  +                    I + 
Sbjct: 303 WIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE--------------------IIRG 342

Query: 262 NIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEH 321
            +    R                        VS E    +   L      R T  E   H
Sbjct: 343 QVFFRQR------------------------VSSECQHLIRWCLALRPSDRPTFEEIQNH 378

Query: 322 PYFYTVVKDQA 332
           P+   V+  Q 
Sbjct: 379 PWMQDVLLPQE 389


>2PL0-A nrPDB
          Length = 289

 Score =  192 bits (487), Expect = 3e-49,   Method: Composition-based stats.
 Identities = 54/297 (18%), Positives = 118/297 (39%), Gaps = 27/297 (9%)

Query: 15  VNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK--P 72
           + T +P++ W  +   V    ++  +LV +LG G++ EV+       + KV VK LK   
Sbjct: 4   MQTQKPQKPWWEDEWEVP---RETLKLVERLGAGQFGEVWMGY-YNGHTKVAVKSLKQGS 59

Query: 73  VKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----- 127
           +       E  +++ L+    ++ L  +V         ++ E++ N       +T     
Sbjct: 60  MSPDAFLAEANLMKQLQHQR-LVRLYAVV---TQEPIYIITEYMENGSLVDFLKTPSGIK 115

Query: 128 LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE 187
           LT   +     +I + + +      +HRD++  N+++  +    ++ D+GLA       E
Sbjct: 116 LTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILV-SDTLSCKIADFGLARLIED-NE 173

Query: 188 YNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLV- 243
           Y  R  +++   +  PE + +Y  +    D+WS G +L  ++      + G  N + +  
Sbjct: 174 YTAREGAKFPIKWTAPEAI-NYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQN 232

Query: 244 -----RIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSP 295
                R+ +     +    + +   +  P              + F  +E Q+   P
Sbjct: 233 LERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP 289


>4R7H-A nrPDB
          Length = 343

 Score =  191 bits (486), Expect = 3e-49,   Method: Composition-based stats.
 Identities = 52/265 (19%), Positives = 98/265 (36%), Gaps = 50/265 (18%)

Query: 9   ARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNE----- 63
           +  + D       E W++         +++ Q  + LG G + +V EA      +     
Sbjct: 30  SYTFIDPTQLPYNEKWEFP--------RNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVL 81

Query: 64  KVVVKILKPV----KKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNT 119
           KV VK+LK      +K+ +  E+KI+ +L    NI+ L             ++ E+    
Sbjct: 82  KVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTH--GGPVLVITEYCTYG 139

Query: 120 DFKQLYQT--------------------------LTDYDIRFYMYEILKALDYCHSMGIM 153
           D     +                           L   D+  +  ++ + + +  S   +
Sbjct: 140 DLLNFLRRKAEAMLGPSLSPGQDPEGLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCI 199

Query: 154 HRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLVDYQMYD 210
           HRDV   NV++ +     ++ D+GLA        Y V+  +R    +  PE + D  +Y 
Sbjct: 200 HRDVAARNVLLTN-GHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFD-SVYT 257

Query: 211 YSLDMWSLGCMLASMIFRKEPFFHG 235
              D+WS G +L  +       + G
Sbjct: 258 VQSDVWSYGILLWEIFSLGLNPYPG 282


>3DKO-A nrPDB
          Length = 318

 Score =  191 bits (485), Expect = 5e-49,   Method: Composition-based stats.
 Identities = 58/311 (18%), Positives = 117/311 (37%), Gaps = 41/311 (13%)

Query: 19  RPREYWDYESHVVEWGNQDD---YQLVRKLGRGKYSEVFEAINITNNEK---VVVKILKP 72
            P  Y D    V ++  + D    ++ R +G G++ EV         ++   V +K LK 
Sbjct: 22  DPETYEDPNRAVHQFAKELDASCIKIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKV 81

Query: 73  VKKKKIKR----EIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT- 127
              +K +R    E  I+      PN++ L  +V     +   +V E + N       +  
Sbjct: 82  GYTEKQRRDFLCEASIMGQF-DHPNVVHLEGVVTR--GKPVMIVIEFMENGALDAFLRKH 138

Query: 128 ---LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHP 184
               T   +   +  I   + Y   MG +HRD+   N++++  +   ++ D+GL+     
Sbjct: 139 DGQFTVIQLVGMLRGIAAGMRYLADMGYVHRDLAARNILVNS-NLVCKVSDFGLSRVIED 197

Query: 185 GQE--YNVRVA--SRYFKGPELLVDYQMYDYSLDMWSLGCMLAS-MIFRKEPFFHGHDNY 239
             E  Y          +  PE +  Y+ +  + D+WS G ++   M + + P++    N 
Sbjct: 198 DPEAVYTTTGGKIPVRWTAPEAIQ-YRKFTSASDVWSYGIVMWEVMSYGERPYWD-MSNQ 255

Query: 240 DQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALD 299
           D +  I +             Y +         L +     W++      +     + + 
Sbjct: 256 DVIKAIEEG------------YRLPAPMDCPAGLHQLMLDCWQK---ERAERPKFEQIVG 300

Query: 300 FLDKLLRYDHQ 310
            LDK++R +  
Sbjct: 301 ILDKMIR-NPN 310


>4UY9-A nrPDB
          Length = 323

 Score =  191 bits (485), Expect = 6e-49,   Method: Composition-based stats.
 Identities = 59/286 (20%), Positives = 114/286 (39%), Gaps = 44/286 (15%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKI-------KREIKILENLRG 90
           +  L   +G G + +V+ A  I   ++V VK  +    + I       ++E K+   L+ 
Sbjct: 10  ELTLEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKH 67

Query: 91  GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY--QTLTDYDIRFYMYEILKALDYCH 148
            PNII L  +          LV E        ++   + +    +  +  +I + ++Y H
Sbjct: 68  -PNIIALRGVCLKEP--NLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLH 124

Query: 149 SMGI---MHRDVKPHNVMI-------DHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFK 198
              I   +HRD+K  N++I       D  ++ L++ D+GLA  +H   + +    +  + 
Sbjct: 125 DEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSA-AGTYAWM 183

Query: 199 GPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYI 258
            PE++    M+    D+WS G +L  ++  + PF  G D       +A           +
Sbjct: 184 APEVIR-ASMFSKGSDVWSYGVLLWELLTGEVPF-RGIDGLAVAYGVA-----------M 230

Query: 259 DKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKL 304
           +K  + +     +   +     W    HS       P   + LD+L
Sbjct: 231 NKLALPIPSTCPEPFAKLMEDCWNPDPHSR------PSFTNILDQL 270


>3V5Q-A nrPDB
          Length = 297

 Score =  190 bits (484), Expect = 6e-49,   Method: Composition-based stats.
 Identities = 59/315 (18%), Positives = 114/315 (36%), Gaps = 73/315 (23%)

Query: 35  NQDDYQLVRKLGRGKYSEVFEAIN-----ITNNEKVVVKILKP---VKKKKIKREIKILE 86
            + D  L R+LG G + +VF A         +   V VK LK      +K  +RE ++L 
Sbjct: 13  KRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLT 72

Query: 87  NLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT------------------- 127
           NL+   +I+    +  D       +VFE++ + D  +  +                    
Sbjct: 73  NLQH-EHIVKFYGVCGD--GDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGE 129

Query: 128 LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE 187
           L    +     +I   + Y  S   +HRD+   N ++   +  +++ D+G++   +    
Sbjct: 130 LGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGA-NLLVKIGDFGMSRDVYSTDY 188

Query: 188 YNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIF-RKEPFFHGHDNYDQLV 243
           Y V   +     +  PE ++ Y+ +    D+WS G +L  +    K+P+F          
Sbjct: 189 YRVGGHTMLPIRWMPPESIM-YRKFTTESDVWSFGVILWEIFTYGKQPWFQ--------- 238

Query: 244 RIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDK 303
                L   ++ + I +  +   PR                       +   E  D +  
Sbjct: 239 -----LSNTEVIECITQGRVLERPR-----------------------VCPKEVYDVMLG 270

Query: 304 LLRYDHQSRLTAREA 318
             + + Q RL  +E 
Sbjct: 271 CWQREPQQRLNIKEI 285


>4EBW-A nrPDB
          Length = 304

 Score =  190 bits (483), Expect = 8e-49,   Method: Composition-based stats.
 Identities = 52/265 (19%), Positives = 107/265 (40%), Gaps = 29/265 (10%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEK---VVVKILKPVK----KKKIKREIKILENL 88
           ++  +L R +G G++ +V + I ++       V +K  K       ++K  +E   +   
Sbjct: 37  RERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQF 96

Query: 89  RGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ----TLTDYDIRFYMYEILKAL 144
              P+I+ L  ++ +       ++ E     + +   Q    +L    +  Y Y++  AL
Sbjct: 97  -DHPHIVKLIGVITE---NPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTAL 152

Query: 145 DYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY--FKGPEL 202
            Y  S   +HRD+   NV++   +  ++L D+GL+ +      Y          +  PE 
Sbjct: 153 AYLESKRFVHRDIAARNVLVSS-NDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPES 211

Query: 203 LVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVL-------GTEDLY 255
           + +++ +  + D+W  G  +  ++      F G  N D + RI               LY
Sbjct: 212 I-NFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLY 270

Query: 256 DYIDK---YNIELDPRFNDILGRHS 277
             + K   Y+    PRF ++  + S
Sbjct: 271 SLMTKCWAYDPSRRPRFTELKAQLS 295


>2W1I-A nrPDB
          Length = 326

 Score =  190 bits (483), Expect = 8e-49,   Method: Composition-based stats.
 Identities = 45/217 (20%), Positives = 97/217 (44%), Gaps = 18/217 (8%)

Query: 26  YESHVVEWGNQDDYQLVRKLGRGKYSEVFEAI----NITNNEKVVVKILKPVKKK---KI 78
           +E        +   + +++LG+G +  V             E V VK L+   ++     
Sbjct: 30  FEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDF 89

Query: 79  KREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDY----DIR 134
           +REI+IL++L+   NI+    +      R   L+ E++     +   Q   +      + 
Sbjct: 90  EREIEILKSLQHD-NIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLL 148

Query: 135 FYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVR--- 191
            Y  +I K ++Y  +   +HRD+   N+++++E+R +++ D+GL +     +EY      
Sbjct: 149 QYTSQICKGMEYLGTKRYIHRDLATRNILVENENR-VKIGDFGLTKVLPQDKEYYKVKEP 207

Query: 192 -VASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIF 227
             +  ++  PE L + + +  + D+WS G +L  +  
Sbjct: 208 GESPIFWYAPESLTESK-FSVASDVWSFGVVLYELFT 243


>2FO0-A nrPDB
          Length = 495

 Score =  190 bits (483), Expect = 9e-49,   Method: Composition-based stats.
 Identities = 55/343 (16%), Positives = 126/343 (36%), Gaps = 63/343 (18%)

Query: 4   PVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNE 63
           P P R +      +    + W+ E        + D  +  KLG G+Y EV+E +    + 
Sbjct: 193 PAPKRNKPTVYGVSPN-YDKWEME--------RTDITMKHKLGGGQYGEVYEGVWKKYSL 243

Query: 64  KVVVKILK--PVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDF 121
            V VK LK   ++ ++  +E  +++ ++  PN++ L  +          ++ E +   + 
Sbjct: 244 TVAVKTLKEDTMEVEEFLKEAAVMKEIKH-PNLVQLLGVCTREP--PFYIITEFMTYGNL 300

Query: 122 KQLYQTLTDYDI-----RFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDW 176
               +     ++      +   +I  A++Y      +HR++   N ++  E+  +++ D+
Sbjct: 301 LDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRNLAARNCLVG-ENHLVKVADF 359

Query: 177 GLAEFYHPGQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFF 233
           GL+     G  Y     +++   +  PE L  Y  +    D+W+ G +L  +       +
Sbjct: 360 GLSRLM-TGDTYTAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSPY 417

Query: 234 HGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLV 293
            G D    L ++ ++L                                E+    E     
Sbjct: 418 PGID----LSQVYELL--------------------------------EKDYRMERPEGC 441

Query: 294 SPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGS 336
             +  + +    +++   R +  E   H  F T+ ++ +    
Sbjct: 442 PEKVYELMRACWQWNPSDRPSFAEI--HQAFETMFQESSISDE 482


>3LLT-A nrPDB
          Length = 360

 Score =  190 bits (483), Expect = 9e-49,   Method: Composition-based stats.
 Identities = 70/330 (21%), Positives = 135/330 (40%), Gaps = 49/330 (14%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK--KKIKREIKILENLRGGPNI-- 94
           + ++RK+G G +  V    +I N +   VK+++ +KK  +  K E  IL+ ++       
Sbjct: 37  FLVIRKMGDGTFGRVLLCQHIDNKKYYAVKVVRNIKKYTRSAKIEADILKKIQNDDINNN 96

Query: 95  --ITLADIVKDPVSRTPALVFEHVNNTDFKQL----YQTLTDYDIRFYMYEILKALDYCH 148
             +               L+FE +  + ++ +    Y      DI+ Y  EILKAL+Y  
Sbjct: 97  NIVKYHGKF--MYYDHMCLIFEPLGPSLYEIITRNNYNGFHIEDIKLYCIEILKALNYLR 154

Query: 149 SMGIMHRDVKPHNVMID------------------------HEHRKLRLIDWGLAEFYHP 184
            M + H D+KP N+++D                         +   ++LID+G A F   
Sbjct: 155 KMSLTHTDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRTKSTGIKLIDFGCATFKSD 214

Query: 185 GQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVR 244
              +   + +R ++ PE++++   +D S DMWS GC+LA +       F  H++ + L  
Sbjct: 215 --YHGSIINTRQYRAPEVILNL-GWDVSSDMWSFGCVLAELYTGSL-LFRTHEHMEHLAM 270

Query: 245 IAKVLGTED---LYDYIDKYNI------ELDPRFNDILGRHSRKRWERFVHSENQHLVSP 295
           +  ++       LY+             EL   + +     +  +  +      + +   
Sbjct: 271 MESIIQPIPKNMLYEATKTNGSKYVNKDELKLAWPENASSINSIKHVKKCLPLYKIIKHE 330

Query: 296 EALDFLDKLLRYDHQSRLTAREAMEHPYFY 325
              DFL  +L+ D   R +  E ++H +  
Sbjct: 331 LFCDFLYSILQIDPTLRPSPAELLKHKFLE 360


>6NPU-A nrPDB
          Length = 298

 Score =  190 bits (483), Expect = 9e-49,   Method: Composition-based stats.
 Identities = 51/311 (16%), Positives = 117/311 (37%), Gaps = 54/311 (17%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK--PVKKKKIKREIKILENLRGGPN 93
           + D  +  KLG G+Y EV+E +    +  V VK LK   ++ ++  +E  +++ ++  PN
Sbjct: 25  RTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKH-PN 83

Query: 94  IITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDI-----RFYMYEILKALDYCH 148
           ++ L  +          ++ E +   +     +     ++      +   +I  A++Y  
Sbjct: 84  LVQLLGVCTREP--PFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLE 141

Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLVD 205
               +HRD+   N ++  E+  +++ D+GL+     G  Y     +++   +  PE L  
Sbjct: 142 KKNFIHRDLAARNCLVG-ENHLVKVADFGLSRLM-TGDTYTAHAGAKFPIKWTAPESLA- 198

Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIEL 265
           Y  +    D+W+ G +L  +       + G D    L ++ ++L                
Sbjct: 199 YNKFSIKSDVWAFGVLLWEIATYGMSPYPGID----LSQVYELL---------------- 238

Query: 266 DPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFY 325
                           E+    E       +  + +    +++   R +  E   H  F 
Sbjct: 239 ----------------EKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEI--HQAFE 280

Query: 326 TVVKDQARMGS 336
           T+ ++ +    
Sbjct: 281 TMFQESSISDE 291


>4E93-A nrPDB
          Length = 377

 Score =  189 bits (481), Expect = 1e-48,   Method: Composition-based stats.
 Identities = 65/299 (21%), Positives = 109/299 (36%), Gaps = 38/299 (12%)

Query: 4   PVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNE 63
           P+  ++ V   ++   P++ W          N +D  L  ++GRG + EVF      +N 
Sbjct: 91  PLTKKSGVV--LHRAVPKDKW--------VLNHEDLVLGEQIGRGNFGEVFSGRLRADNT 140

Query: 64  KVVVK----ILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNT 119
            V VK     L P  K K  +E +IL+     PNI+ L  +      +   +V E V   
Sbjct: 141 LVAVKSCRETLPPDLKAKFLQEARILKQYSH-PNIVRLIGVCTQK--QPIYIVMELVQGG 197

Query: 120 DFKQLYQT----LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLID 175
           DF    +T    L    +   + +    ++Y  S   +HRD+   N ++  ++  L++ D
Sbjct: 198 DFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKN-VLKISD 256

Query: 176 WGLAEFYHPGQEYNVRVASRY----FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEP 231
           +G++     G  Y      R     +  PE L +Y  Y    D+WS G +L         
Sbjct: 257 FGMSREEADG-VYAASGGLRQVPVKWTAPEAL-NYGRYSSESDVWSFGILLWETFSLGAS 314

Query: 232 FFHGHDNYDQLVRIAKVLGTE----------DLYDYIDKYNIELDPRFNDILGRHSRKR 280
            +    N      + K                L +    Y     P F+ I       R
Sbjct: 315 PYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIR 373


>3PPZ-A nrPDB
          Length = 309

 Score =  189 bits (481), Expect = 1e-48,   Method: Composition-based stats.
 Identities = 60/276 (21%), Positives = 114/276 (41%), Gaps = 28/276 (10%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK-----KKKIKREIKILENLRGGP 92
           D  +  K+G G +  V  A    +   V VKIL           +  RE+ I++ LR  P
Sbjct: 38  DLNIKEKIGAGSFGTVHRAEW--HGSDVAVKILMEQDFHAERVNEFLREVAIMKRLRH-P 94

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT------LTDYDIRFYMYEILKALDY 146
           NI+     V  P     ++V E+++     +L         L +       Y++ K ++Y
Sbjct: 95  NIVLFMGAVTQPP--NLSIVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAKGMNY 152

Query: 147 CHSMG--IMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ-EYNVRVASRYFKGPELL 203
            H+    I+HRD+K  N+++D +   +++ D+GL+               +  +  PE+L
Sbjct: 153 LHNRNPPIVHRDLKSPNLLVDKK-YTVKVCDFGLSRLKASTFLSSKSAAGTPEWMAPEVL 211

Query: 204 VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNI 263
            D    +   D++S G +L  +   ++P+  G+ N  Q+  +A V       +     N 
Sbjct: 212 RDEPS-NEKSDVYSFGVILWELATLQQPW--GNLNPAQV--VAAVGFKCKRLEIPRNLNP 266

Query: 264 ELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALD 299
           ++      I G  + + W+R   +    L+ P    
Sbjct: 267 QVA---AIIEGCWTNEPWKRPSFATIMDLLRPLIKS 299


>3DTC-A nrPDB
          Length = 271

 Score =  189 bits (481), Expect = 2e-48,   Method: Composition-based stats.
 Identities = 59/286 (20%), Positives = 114/286 (39%), Gaps = 44/286 (15%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKI-------KREIKILENLRG 90
           +  L   +G G + +V+ A  I   ++V VK  +    + I       ++E K+   L+ 
Sbjct: 8   ELTLEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKH 65

Query: 91  GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY--QTLTDYDIRFYMYEILKALDYCH 148
            PNII L  +          LV E        ++   + +    +  +  +I + ++Y H
Sbjct: 66  -PNIIALRGVCLKEP--NLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLH 122

Query: 149 SMGI---MHRDVKPHNVMI-------DHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFK 198
              I   +HRD+K  N++I       D  ++ L++ D+GLA  +H   + +    +  + 
Sbjct: 123 DEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSA-AGAYAWM 181

Query: 199 GPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYI 258
            PE++    M+    D+WS G +L  ++  + PF  G D       +A           +
Sbjct: 182 APEVIR-ASMFSKGSDVWSYGVLLWELLTGEVPF-RGIDGLAVAYGVA-----------M 228

Query: 259 DKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKL 304
           +K  + +     +   +     W    HS       P   + LD+L
Sbjct: 229 NKLALPIPSTCPEPFAKLMEDCWNPDPHSR------PSFTNILDQL 268


>4H1J-A nrPDB
          Length = 293

 Score =  189 bits (480), Expect = 2e-48,   Method: Composition-based stats.
 Identities = 60/265 (22%), Positives = 115/265 (43%), Gaps = 29/265 (10%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAI---NITNNEKVVVKILKPV----KKKKIKREIKILENL 88
           ++D  L R LG G + EV+E +   +      V VK  K       K+K   E  I++NL
Sbjct: 23  REDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNL 82

Query: 89  RGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ----TLTDYDIRFYMYEILKAL 144
              P+I+ L  I+++  +    ++ E     +     +    +L    +  Y  +I KA+
Sbjct: 83  -DHPHIVKLIGIIEEEPT---WIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAM 138

Query: 145 DYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY--FKGPEL 202
            Y  S+  +HRD+   N+++      ++L D+GL+ +      Y   V      +  PE 
Sbjct: 139 AYLESINCVHRDIAVRNILVASPEC-VKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPES 197

Query: 203 LVDYQMYDYSLDMWSLGCMLASMI-FRKEPFF--HGHDNYDQLVRIAKV----LGTEDLY 255
           + +++ +  + D+W     +  ++ F K+PFF     D    L +  ++    L    LY
Sbjct: 198 I-NFRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLY 256

Query: 256 DYIDK---YNIELDPRFNDILGRHS 277
             + +   Y+    PRF +++   S
Sbjct: 257 TLMTRCWDYDPSDRPRFTELVCSLS 281


>2J0K-A nrPDB
          Length = 656

 Score =  189 bits (480), Expect = 2e-48,   Method: Composition-based stats.
 Identities = 52/265 (19%), Positives = 106/265 (40%), Gaps = 29/265 (10%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNN---EKVVVKILKPVK----KKKIKREIKILENL 88
           ++  +L R +G G++ +V + I ++       V +K  K       ++K  +E   +   
Sbjct: 389 RERIELGRCIGEGQFGDVHQGIYMSPENPAMAVAIKTCKNCTSDSVREKFLQEALTMRQF 448

Query: 89  RGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ----TLTDYDIRFYMYEILKAL 144
              P+I+ L  ++ +       ++ E     + +   Q    +L    +  Y Y++  AL
Sbjct: 449 -DHPHIVKLIGVITE---NPVWIIMELCTLGELRSFLQVRKFSLDLASLILYAYQLSTAL 504

Query: 145 DYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY--FKGPEL 202
            Y  S   +HRD+   NV++      ++L D+GL+ +      Y          +  PE 
Sbjct: 505 AYLESKRFVHRDIAARNVLVSATDC-VKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPES 563

Query: 203 LVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVL-------GTEDLY 255
           + +++ +  + D+W  G  +  ++      F G  N D + RI               LY
Sbjct: 564 I-NFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLY 622

Query: 256 DYIDK---YNIELDPRFNDILGRHS 277
             + K   Y+    PRF ++  + S
Sbjct: 623 SLMTKCWAYDPSRRPRFTELKAQLS 647


>4X7Q-B nrPDB
          Length = 312

 Score =  189 bits (479), Expect = 3e-48,   Method: Composition-based stats.
 Identities = 68/323 (21%), Positives = 118/323 (36%), Gaps = 63/323 (19%)

Query: 34  GNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP---------VKKKKIKREIKI 84
             + +Y+L   LG+G +  VF    +T+  +V +K++                   E+ +
Sbjct: 28  AFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVAL 87

Query: 85  LENLR---GGPNIITLADIVKDPVSRTPALVFEH-VNNTDFKQLY---QTLTDYDIRFYM 137
           L  +    G P +I L D  +        LV E  +   D          L +   R + 
Sbjct: 88  LWKVGAGGGHPGVIRLLDWFE--TQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFF 145

Query: 138 YEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYF 197
            +++ A+ +CHS G++HRD+K  N++ID      +LID+G     H  + Y     +R +
Sbjct: 146 GQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHD-EPYTDFDGTRVY 204

Query: 198 KGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDY 257
             PE +  +Q +     +WSLG +L  M+    PF           R  ++L  E  +  
Sbjct: 205 SPPEWISRHQYHALPATVWSLGILLYDMVCGDIPF----------ERDQEILEAELHFPA 254

Query: 258 IDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTARE 317
                                              VSP+    + + L     SR +  E
Sbjct: 255 H----------------------------------VSPDCCALIRRCLAPKPSSRPSLEE 280

Query: 318 AMEHPYFYTVVKDQARMGSSSMP 340
            +  P+  T  +D     S   P
Sbjct: 281 ILLDPWMQTPAEDVPLNPSKGGP 303


>3TT0-A nrPDB
          Length = 382

 Score =  189 bits (479), Expect = 3e-48,   Method: Composition-based stats.
 Identities = 50/275 (18%), Positives = 109/275 (39%), Gaps = 37/275 (13%)

Query: 36  QDDYQLVRKLGRGKYSEVFEA------INITNN-EKVVVKILKPVKKKK----IKREIKI 84
           +D   L + LG G + +V  A       +  N   KV VK+LK    +K    +  E+++
Sbjct: 68  RDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEM 127

Query: 85  LENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----------------- 127
           ++ +    NII L             ++ E+ +  + ++  Q                  
Sbjct: 128 MKMIGKHKNIINLLGACTQ--DGPLYVIVEYASKGNLREYLQARRPPGLEYSYNPSHNPE 185

Query: 128 --LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPG 185
             L+  D+    Y++ + ++Y  S   +HRD+   NV++  ++  +++ D+GLA   H  
Sbjct: 186 EQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDN-VMKIADFGLARDIHHI 244

Query: 186 QEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQL 242
             Y      R    +  PE L D ++Y +  D+WS G +L  +       + G    +  
Sbjct: 245 DYYKKTTNGRLPVKWMAPEALFD-RIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELF 303

Query: 243 VRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHS 277
             + +    +   +  ++  + +   ++ +  +  
Sbjct: 304 KLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRP 338


>3PP0-A nrPDB
          Length = 338

 Score =  188 bits (478), Expect = 4e-48,   Method: Composition-based stats.
 Identities = 71/312 (22%), Positives = 134/312 (42%), Gaps = 35/312 (11%)

Query: 35  NQDDYQLVRKLGRGKYSEVFEAINITNNEKV----VVKILK----PVKKKKIKREIKILE 86
            + + + V+ LG G +  V++ I I + E V     +K+L+    P   K+I  E  ++ 
Sbjct: 15  KETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMA 74

Query: 87  NLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ----TLTDYDIRFYMYEILK 142
            + G P +  L  I    ++ T  LV + +         +     L   D+  +  +I K
Sbjct: 75  GV-GSPYVSRLLGIC---LTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAK 130

Query: 143 ALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ-EYNVRVASRY--FKG 199
            + Y   + ++HRD+   NV++   +  +++ D+GLA      + EY+         +  
Sbjct: 131 GMSYLEDVRLVHRDLAARNVLVKSPNH-VKITDFGLARLLDIDETEYHADGGKVPIKWMA 189

Query: 200 PELLVDYQMYDYSLDMWSLGCMLAS-MIFRKEPF--FHGHDNYDQLVRIAKV----LGTE 252
            E ++  + + +  D+WS G  +   M F  +P+      +  D L +  ++    + T 
Sbjct: 190 LESIL-RRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTI 248

Query: 253 DLYDYIDKYNI---ELDPRFNDILGRHSR--KRWERFVHSENQHLVSPEALD--FLDKLL 305
           D+Y  + K  +   E  PRF +++   SR  +  +RFV  +N+ L     LD  F   LL
Sbjct: 249 DVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLL 308

Query: 306 RYDHQSRLTARE 317
             D    L   E
Sbjct: 309 EDDDMGDLVDAE 320


>4AT3-A nrPDB
          Length = 299

 Score =  188 bits (477), Expect = 4e-48,   Method: Composition-based stats.
 Identities = 61/297 (20%), Positives = 115/297 (38%), Gaps = 39/297 (13%)

Query: 35  NQDDYQLVRKLGRGKYSEVFEAINIT-----NNEKVVVKILKPVK---KKKIKREIKILE 86
            + +  L R+LG G + +VF A         +   V VK LK      +K   RE ++L 
Sbjct: 11  KRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLT 70

Query: 87  NLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----------------LTD 130
           NL+   +I+    +  +       +VFE++ + D  +  +                 LT 
Sbjct: 71  NLQH-EHIVKFYGVCVE--GDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQ 127

Query: 131 YDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNV 190
             +     +I   + Y  S   +HRD+   N ++  E+  +++ D+G++   +    Y V
Sbjct: 128 SQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVG-ENLLVKIGDFGMSRDVYSTDYYRV 186

Query: 191 RVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIF-RKEPFFHGHDNYDQLVRIA 246
              +     +  PE ++ Y+ +    D+WSLG +L  +    K+P++   +N + +  I 
Sbjct: 187 GGHTMLPIRWMPPESIM-YRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNN-EVIECIT 244

Query: 247 --KVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFL 301
             +VL          +   EL            +         +N    SP  LD L
Sbjct: 245 QGRVLQRPRT---CPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDIL 298


>4C59-A nrPDB
          Length = 340

 Score =  188 bits (477), Expect = 4e-48,   Method: Composition-based stats.
 Identities = 58/329 (17%), Positives = 125/329 (37%), Gaps = 73/329 (22%)

Query: 21  REYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL---KPVKKKK 77
           R+  D+    VE G +   ++ R L  G ++ V+EA ++ +  +  +K L   +  K + 
Sbjct: 12  RDQSDFVGQTVELG-ELRLRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRA 70

Query: 78  IKREIKILENLRGGPNIITL-----ADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTD-- 130
           I +E+  ++ L G PNI+           +    +   L+   +      +  + +    
Sbjct: 71  IIQEVCFMKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRG 130

Query: 131 ----YDIRFYMYEILKALDYCHSMG--IMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHP 184
                 +    Y+  +A+ + H     I+HRD+K  N+++ ++   ++L D+G A     
Sbjct: 131 PLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQG-TIKLCDFGSATTISH 189

Query: 185 GQEYN-------------VRVASRYFKGPELLVDYQMY--DYSLDMWSLGCMLASMIFRK 229
             +Y+              R  +  ++ PE++  Y  +      D+W+LGC+L  + FR+
Sbjct: 190 YPDYSWSAQRRALVEEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQ 249

Query: 230 EPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSEN 289
            PF  G        ++  V G   +  +  +Y +                          
Sbjct: 250 HPFEDG-------AKLRIVNGKYSIPPHDTQYTV-------------------------- 276

Query: 290 QHLVSPEALDFLDKLLRYDHQSRLTAREA 318
                      +  +L+ + + RL+  E 
Sbjct: 277 -------FHSLIRAMLQVNPEERLSIAEV 298


>3BBT-B nrPDB
          Length = 328

 Score =  187 bits (476), Expect = 5e-48,   Method: Composition-based stats.
 Identities = 61/301 (20%), Positives = 121/301 (40%), Gaps = 36/301 (11%)

Query: 35  NQDDYQLVRKLGRGKYSEVFEAINITNNEKV----VVKILK----PVKKKKIKREIKILE 86
            + + + V+ LG G +  V++ I +   E V     +KIL     P    +   E  I+ 
Sbjct: 13  KETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMA 72

Query: 87  NLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----LTDYDIRFYMYEILK 142
           +    P+++ L  +   P   T  LV + + +    +        +    +  +  +I K
Sbjct: 73  S-MDHPHLVRLLGVCLSP---TIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAK 128

Query: 143 ALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH-PGQEYNVRVASRY--FKG 199
            + Y     ++HRD+   NV++   +  +++ D+GLA       +EYN         +  
Sbjct: 129 GMMYLEERRLVHRDLAARNVLVKSPNH-VKITDFGLARLLEGDEKEYNADGGKMPIKWMA 187

Query: 200 PELLVDYQMYDYSLDMWSLGCMLAS-MIFRKEPF--FHGHDNYDQLVRIAKV----LGTE 252
            E +  Y+ + +  D+WS G  +   M F  +P+      +  D L +  ++    + T 
Sbjct: 188 LECI-HYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTI 246

Query: 253 DLYDYIDKYNI---ELDPRFNDILGRHSR-----KRWERFVHSENQHLVSPEALDFLDKL 304
           D+Y  + K  +   +  P+F ++    SR     +R+      +   L SP    F   L
Sbjct: 247 DVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNL 306

Query: 305 L 305
           L
Sbjct: 307 L 307


>5A46-A nrPDB
          Length = 386

 Score =  187 bits (475), Expect = 7e-48,   Method: Composition-based stats.
 Identities = 56/309 (18%), Positives = 119/309 (38%), Gaps = 38/309 (12%)

Query: 36  QDDYQLVRKLGRGKYSEVFEA------INITNN-EKVVVKILKPVKKKK----IKREIKI 84
           +D   L + LG G + +V  A       +  N   KV VK+LK    +K    +  E+++
Sbjct: 39  RDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEM 98

Query: 85  LENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----------------- 127
           ++ +    NII L             ++ E+ +  + ++  Q                  
Sbjct: 99  MKMIGKHKNIINLLGACTQ--DGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPE 156

Query: 128 --LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPG 185
             L+  D+    Y++ + ++Y  S   +HRD+   NV++  ++  +++ D+GLA   H  
Sbjct: 157 EQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDN-VMKIADFGLARDIHHI 215

Query: 186 QEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQL 242
             Y      R    +  PE L D ++Y +  D+WS G +L  +       + G    +  
Sbjct: 216 DYYKKTTNGRLPVKWMAPEALFD-RIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELF 274

Query: 243 VRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSR-KRWERFVHSENQHLVSPEALDFL 301
             + +    +   +  ++  + +   ++ +  +    K+    +        + E LD  
Sbjct: 275 KLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLS 334

Query: 302 DKLLRYDHQ 310
             L +Y   
Sbjct: 335 MPLDQYSPS 343


>3GQL-A nrPDB
          Length = 326

 Score =  187 bits (475), Expect = 7e-48,   Method: Composition-based stats.
 Identities = 54/299 (18%), Positives = 116/299 (38%), Gaps = 38/299 (12%)

Query: 36  QDDYQLVRKLGRGKYSEVFEA------INITNN-EKVVVKILKPVKKKK----IKREIKI 84
           +D   L + LG G + +V  A       +  N   KV VK+LK    +K    +  E+++
Sbjct: 27  RDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEM 86

Query: 85  LENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----------------- 127
           ++ +    NII L             ++ E+ +  + ++  Q                  
Sbjct: 87  MKMIGKHKNIINLLGACTQ--DGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPE 144

Query: 128 --LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPG 185
             L+  D+    Y++ + ++Y  S   +HRD+   NV++  ++  +++ D+GLA   H  
Sbjct: 145 EQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDN-VMKIADFGLARDIHHI 203

Query: 186 QEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQL 242
             Y      R    +  PE L D ++Y +  D+WS G +L  +       + G    +  
Sbjct: 204 DYYKKTTNGRLPVKWMAPEALFD-RIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELF 262

Query: 243 VRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSR-KRWERFVHSENQHLVSPEALDF 300
             + +    +   +  ++  + +   ++ +  +    K+    +        + E LD 
Sbjct: 263 KLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDL 321


>3ORP-A nrPDB
          Length = 311

 Score =  187 bits (475), Expect = 7e-48,   Method: Composition-based stats.
 Identities = 75/337 (22%), Positives = 134/337 (39%), Gaps = 62/337 (18%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK------PVKKKKIKREIKILENLRG 90
           D Y+L   LG G  SEV  A ++ ++  V VK+L+      P    + +RE +    L  
Sbjct: 12  DRYELGEILGFGGMSEVHLARDLRDHRDVAVKVLRADLARDPSFYLRFRREAQNAAAL-N 70

Query: 91  GPNIITLADIVK--DPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALD 145
            P I+ + D  +   P    P +V E+V+    + +  T   +T       + +  +AL+
Sbjct: 71  HPAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIVHTEGPMTPKRAIEVIADACQALN 130

Query: 146 YCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVR----VASRYFKGPE 201
           + H  GI+HRDVKP N+MI   +  ++++D+G+A           +    + +  +  PE
Sbjct: 131 FSHQNGIIHRDVKPANIMISATN-AVKVMDFGIARAIADSGNSVTQTAAVIGTAQYLSPE 189

Query: 202 LLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKY 261
                 + D   D++SLGC+L  ++  + PF                  T D    +   
Sbjct: 190 QARGDSV-DARSDVYSLGCVLYEVLTGEPPF------------------TGDSPVSVAYQ 230

Query: 262 NIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRL-TAREAME 320
           ++  DP                   S     +S +    + K L  + ++R  TA E   
Sbjct: 231 HVREDP----------------IPPSARHEGLSADLDAVVLKALAKNPENRYQTAAE--- 271

Query: 321 HPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISS 357
                 +  D  R+ +   P     ++ A   S +SS
Sbjct: 272 ------MRADLVRVHNGEPPEAPKVLTDAERTSLLSS 302


>4UYA-A nrPDB
          Length = 340

 Score =  187 bits (475), Expect = 8e-48,   Method: Composition-based stats.
 Identities = 49/269 (18%), Positives = 110/269 (40%), Gaps = 38/269 (14%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK-------KKIKREIKILENLR 89
           +  +L   +G G + +V+ A      ++V VK  +   +       + ++RE ++   LR
Sbjct: 26  ERLELKELIGAGGFGQVYRATWQ--GQEVAVKAARQDPEQDAAAAAESVRREARLFAMLR 83

Query: 90  GGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY--QTLTDYDIRFYMYEILKALDYC 147
             PNII L  +          LV E        +    + +  + +  +  +I + + Y 
Sbjct: 84  H-PNIIELRGVCLQQP--HLCLVLEFARGGALNRALAGRRIPPHVLVNWAVQIARGMLYL 140

Query: 148 HSMG---IMHRDVKPHNVMIDHE-------HRKLRLIDWGLAEFYHPGQEYNVRVASRYF 197
           H      I+HRD+K  N+++  +       ++ L++ D+GLA  +H   +      +  +
Sbjct: 141 HEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTKMAT-AGAYAW 199

Query: 198 KGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDY 257
             PE++    ++    D+WS G +L  ++  + P + G D       +A           
Sbjct: 200 MAPEVI-KSSLFSKGSDIWSYGVLLWELLTGEVP-YRGIDGLAVAYGVA----------- 246

Query: 258 IDKYNIELDPRFNDILGRHSRKRWERFVH 286
           ++K  + +     +   +  ++ W++  H
Sbjct: 247 VNKLTLPIPSTCPEPFAKLMKECWQQDPH 275


>2HK5-A nrPDB
          Length = 270

 Score =  187 bits (474), Expect = 8e-48,   Method: Composition-based stats.
 Identities = 43/279 (15%), Positives = 111/279 (39%), Gaps = 23/279 (8%)

Query: 21  REYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEA-INITNNEKVVVKILKP--VKKKK 77
           ++ W+ ++  +    ++  +L +KLG G++ EV+ A  N     KV VK +KP  +  + 
Sbjct: 2   QKPWEKDAWEIP---RESLKLEKKLGAGQFGEVWMATYNKHT--KVAVKTMKPGSMSVEA 56

Query: 78  IKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ-----TLTDYD 132
              E  +++ L+    ++ L  +V         ++ E +         +           
Sbjct: 57  FLAEANVMKTLQHDK-LVKLHAVV---TKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPK 112

Query: 133 IRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRV 192
           +  +  +I + + +      +HRD++  N+++       ++ D+GLA       EY  R 
Sbjct: 113 LIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSA-SLVCKIADFGLARVIED-NEYTARE 170

Query: 193 ASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVL 249
            +++   +  PE + ++  +    D+WS G +L  ++      + G  N + +  + +  
Sbjct: 171 GAKFPIKWTAPEAI-NFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGY 229

Query: 250 GTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSE 288
                 +  ++    +   + +         + + V  +
Sbjct: 230 RMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDD 268


>4P5Q-A nrPDB
          Length = 361

 Score =  187 bits (474), Expect = 9e-48,   Method: Composition-based stats.
 Identities = 62/306 (20%), Positives = 116/306 (37%), Gaps = 38/306 (12%)

Query: 20  PREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEK---VVVKILKPVKKK 76
           PR          +  +  +  + + +G G++ EV        ++K   V +K LK    +
Sbjct: 16  PRGSTQTVHEFAKELDATNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTE 75

Query: 77  KIKR----EIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----L 128
           K +R    E  I+      PNII L  +V    S+   +V E++ N       +      
Sbjct: 76  KQRRDFLGEASIMGQF-DHPNIIRLEGVVT--KSKPVMIVTEYMENGSLDSFLRKHDAQF 132

Query: 129 TDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE- 187
           T   +   +  I   + Y   MG +HRD+   N++I+  +   ++ D+GL+       E 
Sbjct: 133 TVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINS-NLVCKVSDFGLSRVLEDDPEA 191

Query: 188 -YNVRVA--SRYFKGPELLVDYQMYDYSLDMWSLGCMLAS-MIFRKEPFFHGHDNYDQLV 243
            Y  R       +  PE +  Y+ +  + D+WS G +L   M + + P++    N D + 
Sbjct: 192 AYTTRGGKIPIRWTSPEAIA-YRKFTSASDVWSYGIVLWEVMSYGERPYWE-MSNQDVIK 249

Query: 244 RIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDK 303
            + +        D                L +     W++     N      + +  LDK
Sbjct: 250 AVDEGYRLPPPMD------------CPAALYQLMLDCWQK---DRNNRPKFEQIVSILDK 294

Query: 304 LLRYDH 309
           L+R + 
Sbjct: 295 LIR-NP 299


>1FVR-A nrPDB
          Length = 327

 Score =  187 bits (474), Expect = 9e-48,   Method: Composition-based stats.
 Identities = 50/317 (15%), Positives = 109/317 (34%), Gaps = 68/317 (21%)

Query: 28  SHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKV--VVKILKPVKKKKIKR----E 81
             V++W   +D +    +G G + +V +A    +  ++   +K +K    K   R    E
Sbjct: 19  YPVLDW---NDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGE 75

Query: 82  IKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ--------------- 126
           +++L  L   PNII L    +        L  E+  + +     +               
Sbjct: 76  LEVLCKLGHHPNIINLLGACEH--RGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIAN 133

Query: 127 ----TLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFY 182
               TL+   +  +  ++ + +DY      +HRD+   N+++  E+   ++ D+GL+   
Sbjct: 134 STASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVG-ENYVAKIADFGLSRGQ 192

Query: 183 HPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQL 242
               +  +      +   E L +Y +Y  + D+WS G +L  ++      + G       
Sbjct: 193 EVYVKKTMGRLPVRWMAIESL-NYSVYTTNSDVWSYGVLLWEIVSLGGTPYCG------- 244

Query: 243 VRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLD 302
                 +   +LY+ + +      P                            E  D + 
Sbjct: 245 ------MTCAELYEKLPQGYRLEKP-----------------------LNCDDEVYDLMR 275

Query: 303 KLLRYDHQSRLTAREAM 319
           +  R     R +  + +
Sbjct: 276 QCWREKPYERPSFAQIL 292


>1JPA-A nrPDB
          Length = 312

 Score =  187 bits (474), Expect = 9e-48,   Method: Composition-based stats.
 Identities = 57/313 (18%), Positives = 117/313 (37%), Gaps = 43/313 (13%)

Query: 19  RPREYWDYESHVVEWGNQDDY---QLVRKLGRGKYSEVFEAINITNNEK---VVVKILKP 72
            P  + D    V E+  + D    ++ + +G G++ EV         ++   V +K LK 
Sbjct: 12  DPFTFEDPNEAVREFAKEIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKS 71

Query: 73  VKKKKIKR----EIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT- 127
              +K +R    E  I+      PN+I L  +V         ++ E + N       +  
Sbjct: 72  GYTEKQRRDFLSEASIMGQF-DHPNVIHLEGVVTKST--PVMIITEFMENGSLDSFLRQN 128

Query: 128 ---LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHP 184
               T   +   +  I   + Y   M  +HRD+   N++++  +   ++ D+GL+ F   
Sbjct: 129 DGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNS-NLVCKVSDFGLSRFLED 187

Query: 185 GQ---EYNVRVASR---YFKGPELLVDYQMYDYSLDMWSLGCMLAS-MIFRKEPFFHGHD 237
                 Y   +  +    +  PE +  Y+ +  + D+WS G ++   M + + P++    
Sbjct: 188 DTSDPTYTSALGGKIPIRWTAPEAIQ-YRKFTSASDVWSYGIVMWEVMSYGERPYWD-MT 245

Query: 238 NYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEA 297
           N D +  I +        D                L +     W++     N      + 
Sbjct: 246 NQDVINAIEQDYRLPPPMD------------CPSALHQLMLDCWQK---DRNHRPKFGQI 290

Query: 298 LDFLDKLLRYDHQ 310
           ++ LDK++R +  
Sbjct: 291 VNTLDKMIR-NPN 302


>3C1X-A nrPDB
          Length = 373

 Score =  186 bits (472), Expect = 1e-47,   Method: Composition-based stats.
 Identities = 61/294 (20%), Positives = 123/294 (41%), Gaps = 31/294 (10%)

Query: 10  RVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEK---VV 66
            V+ D++   P E      HVV   +         +GRG +  V+    + N+ K     
Sbjct: 63  TVHIDLSALNP-ELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCA 121

Query: 67  VKILKPV----KKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFK 122
           VK L  +    +  +   E  I+++    PN+++L  I           V  ++ + D +
Sbjct: 122 VKSLNRITDIGEVSQFLTEGIIMKDFSH-PNVLSLLGICLRSEGSPLV-VLPYMKHGDLR 179

Query: 123 QLYQTLTD----YDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGL 178
              +  T      D+  +  ++ K + +  S   +HRD+   N M+D E   +++ D+GL
Sbjct: 180 NFIRNETHNPTVKDLIGFGLQVAKGMKFLASKKFVHRDLAARNCMLD-EKFTVKVADFGL 238

Query: 179 AEFYHPGQ--EYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFF 233
           A   +  +    + +  ++    +   E L   Q +    D+WS G +L  ++ R  P +
Sbjct: 239 ARDMYDKEFDSVHNKTGAKLPVKWMALESLQT-QKFTTKSDVWSFGVLLWELMTRGAPPY 297

Query: 234 HGHDNYD---QLVRIAKVLGTE----DLYDYIDKY---NIELDPRFNDILGRHS 277
              + +D    L++  ++L  E     LY+ + K      E+ P F++++ R S
Sbjct: 298 PDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRIS 351


>6HV0-A nrPDB
          Length = 416

 Score =  185 bits (471), Expect = 2e-47,   Method: Composition-based stats.
 Identities = 67/305 (21%), Positives = 122/305 (40%), Gaps = 60/305 (19%)

Query: 44  KLGRGKYSE-VFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVK 102
            LG G     V+    + +N  V VK + P       RE+++L      PN+I      K
Sbjct: 15  VLGHGAEGTIVYRG--MFDNRDVAVKRILPECFSFADREVQLLRESDEHPNVIRYFCTEK 72

Query: 103 DPVSRTPALVF------EHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRD 156
           D   +  A+        E+V   DF  L       +    + +    L + HS+ I+HRD
Sbjct: 73  DRQFQYIAIELCAATLQEYVEQKDFAHLG-----LEPITLLQQTTSGLAHLHSLNIVHRD 127

Query: 157 VKPHNVMIDHEHRKLR----LIDWGLAEFYHPGQEYNVRV----ASRYFKGPELLVD--Y 206
           +KPHN++I   +   +    + D+GL +    G+    R      +  +  PE+L +   
Sbjct: 128 LKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCK 187

Query: 207 QMYDYSLDMWSLGCMLASMIF-RKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIEL 265
           +   Y++D++S GC+   +I     PF         L R A +L      D +       
Sbjct: 188 ENPTYTVDIFSAGCVFYYVISEGSHPF------GKSLQRQANILLGACSLDCLH------ 235

Query: 266 DPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFY 325
             +  D++                       A + ++K++  D Q R +A+  ++HP+F+
Sbjct: 236 PEKHEDVI-----------------------ARELIEKMIAMDPQKRPSAKHVLKHPFFW 272

Query: 326 TVVKD 330
           ++ K 
Sbjct: 273 SLEKQ 277


>5GRN-A nrPDB
          Length = 356

 Score =  185 bits (471), Expect = 2e-47,   Method: Composition-based stats.
 Identities = 54/266 (20%), Positives = 100/266 (37%), Gaps = 53/266 (19%)

Query: 11  VYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNE-----KV 65
           +Y D         W++         +D   L R LG G + +V E      +      KV
Sbjct: 28  IYVDPMQLPYDSRWEFP--------RDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKV 79

Query: 66  VVKILKPV----KKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDF 121
            VK+LKP     +K+ +  E+KI+ +L    NI+ L        S    ++ E+    D 
Sbjct: 80  AVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACT--KSGPIYIITEYCFYGDL 137

Query: 122 KQLYQT-----------------------------LTDYDIRFYMYEILKALDYCHSMGI 152
                                              LT  D+  + Y++ + +++  S   
Sbjct: 138 VNYLHKNRDSFLSHKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNC 197

Query: 153 MHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLVDYQMY 209
           +HRD+   NV++  + + +++ D+GLA        Y  + ++     +  PE + D  +Y
Sbjct: 198 VHRDLAARNVLL-AQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFD-NLY 255

Query: 210 DYSLDMWSLGCMLASMIFRKEPFFHG 235
               D+WS G +L  +       + G
Sbjct: 256 TTLSDVWSYGILLWEIFSLGGTPYPG 281


>5MJB-A nrPDB
          Length = 305

 Score =  185 bits (471), Expect = 2e-47,   Method: Composition-based stats.
 Identities = 57/307 (18%), Positives = 116/307 (37%), Gaps = 43/307 (14%)

Query: 25  DYESHVVEWGNQDDY---QLVRKLGRGKYSEVFEAINITNNEK---VVVKILK----PVK 74
           D    V E+  + D    ++   +G G++ EV++       ++   V +K LK      +
Sbjct: 11  DPNEAVREFAKEIDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQ 70

Query: 75  KKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----LTD 130
           ++    E  I+       NII L  +V    SR   ++ E + N       +      T 
Sbjct: 71  RRDFLSEASIMGQF-DHRNIIRLEGVVT--KSRPVMIITEFMENCALDSFLRQNDGQFTV 127

Query: 131 YDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ---E 187
             +   +  I   + Y   M  +HRD+   N++++  +   ++ D+GL+ +         
Sbjct: 128 IQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNS-NLVCKVSDFGLSRYLQDDTSDPT 186

Query: 188 YNVRVASR---YFKGPELLVDYQMYDYSLDMWSLGCMLAS-MIFRKEPFFHGHDNYDQLV 243
           Y   +  +    +  PE +  Y+ +  + D+WS G ++   M F + P++    N D + 
Sbjct: 187 YTSSLGGKIPVRWTAPEAIA-YRKFTSASDVWSYGIVMWEVMSFGERPYWD-MSNQDVIN 244

Query: 244 RIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDK 303
            I +        D                L +     W++     N      E ++ LDK
Sbjct: 245 AIEQDYRLPPPMD------------CPAALHQLMLDCWQK---DRNSRPRFAEIVNTLDK 289

Query: 304 LLRYDHQ 310
           ++R +  
Sbjct: 290 MIR-NPA 295


>2Y6O-A nrPDB
          Length = 291

 Score =  185 bits (470), Expect = 3e-47,   Method: Composition-based stats.
 Identities = 49/275 (17%), Positives = 110/275 (40%), Gaps = 24/275 (8%)

Query: 40  QLVRKLGRGKYSEVFEAINITNNEK---VVVKILKP----VKKKKIKREIKILENLRGGP 92
           ++ + +G G++ EV         ++   V +K LK      +++    E  I+      P
Sbjct: 17  KIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQF-DHP 75

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----LTDYDIRFYMYEILKALDYCH 148
           NII L  +V     +   ++ E++ N       +      T   +   +  I   + Y  
Sbjct: 76  NIIHLEGVVT--KCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYLS 133

Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE--YNVRVA--SRYFKGPELLV 204
            M  +HRD+   N++++  +   ++ D+G++       E  Y  R       +  PE + 
Sbjct: 134 DMSYVHRDLAARNILVNS-NLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIA 192

Query: 205 DYQMYDYSLDMWSLGCMLAS-MIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNI 263
            Y+ +  + D+WS G ++   M + + P++    N D +  I +        D     + 
Sbjct: 193 -YRKFTSASDVWSYGIVMWEVMSYGERPYWD-MSNQDVIKAIEEGYRLPPPMDCPIALHQ 250

Query: 264 ELDPRFNDILGRHSRKRWERFVHSENQHLVSPEAL 298
            +   +     R  R ++ + V+  ++ + +P +L
Sbjct: 251 LMLDCWQK--ERSDRPKFGQIVNMLDKLIRNPNSL 283


>5L6P-A nrPDB
          Length = 298

 Score =  185 bits (470), Expect = 3e-47,   Method: Composition-based stats.
 Identities = 55/298 (18%), Positives = 120/298 (40%), Gaps = 29/298 (9%)

Query: 25  DYESHVVEWGNQDDY---QLVRKLGRGKYSEVFEAINITNNEK---VVVKILKPVKKKKI 78
           D    V E+  + D    ++   +G G++ EV          +   V +K LK    ++ 
Sbjct: 4   DPNEAVREFAKEIDVSCVKIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQ 63

Query: 79  KR----EIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ----TLTD 130
           +R    E  I+      PNII L  +V    SR   ++ E + N       +      T 
Sbjct: 64  RRDFLSEASIMGQF-DHPNIIRLEGVVT--KSRPVMILTEFMENCALDSFLRLNDGQFTV 120

Query: 131 YDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHP---GQE 187
             +   +  I   + Y   M  +HRD+   N++++  +   ++ D+GL+ F         
Sbjct: 121 IQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNS-NLVCKVSDFGLSRFLEDDPSDPT 179

Query: 188 YNVRVASR---YFKGPELLVDYQMYDYSLDMWSLGCMLAS-MIFRKEPFFHGHDNYDQLV 243
           Y   +  +    +  PE +  Y+ +  + D+WS G ++   M + + P++    N D + 
Sbjct: 180 YTSSLGGKIPIRWTAPEAIA-YRKFTSASDVWSYGIVMWEVMSYGERPYWD-MSNQDVIN 237

Query: 244 RIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFL 301
            + +        D     +  +   +  +  R+ R ++ + V++ ++ + +P +L  +
Sbjct: 238 AVEQDYRLPPPMDCPTALHQLMLDCW--VRDRNLRPKFSQIVNTLDKLIRNPASLKVI 293


>4JLC-A nrPDB
          Length = 657

 Score =  185 bits (470), Expect = 3e-47,   Method: Composition-based stats.
 Identities = 65/349 (18%), Positives = 132/349 (37%), Gaps = 61/349 (17%)

Query: 41  LVRKLGRGKYSEVFEAINITNNEKVVVKI------LKPVKKKKIKREIKILENLRGGPNI 94
           L   LG+G  + VF   +    +   VK+      L+PV  +   RE ++L+ L    NI
Sbjct: 12  LSDILGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQ--MREFEVLKKL-NHKNI 68

Query: 95  ITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT------LTDYDIRFYMYEILKALDYCH 148
           + L  I ++  +R   L+ E         + +       L + +    + +++  +++  
Sbjct: 69  VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 128

Query: 149 SMGIMHRDVKPHNVM--IDHEHRKL-RLIDWGLAEFYHPGQEYNVRVASRYFKGPELLV- 204
             GI+HRD+KP N+M  I  + + + +L D+G A      +++     +  +  P++   
Sbjct: 129 ENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYER 188

Query: 205 ------DYQMYDYSLDMWSLGCMLASMIFRKEPFFH---GHDNYDQLVRIA------KVL 249
                   + Y  ++D+WS+G           PF        N + + +I        + 
Sbjct: 189 AVLRKDHQKKYGATVDLWSVGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAIS 248

Query: 250 GTEDLYDYIDKYNIELD--------------PRFNDILGRHSRKRWERFVHSENQHLVSP 295
           G +   +    ++ ++               P   +IL     K W              
Sbjct: 249 GVQKAENGPIDWSGDMPLSCSLSQGLQALLTPVLANILEADQEKCWG-------FDQFFA 301

Query: 296 EALDFLDKL-LRYDHQSRLTAREAMEHPY-----FYTVVKDQARMGSSS 338
           E  D L ++ +       +TA +   H Y     F+ +V  Q ++ SS+
Sbjct: 302 ETSDVLHRMVIHVFSLQHMTAHKIYIHSYNTAAVFHELVYKQTKIVSSN 350


>5HLW-A nrPDB
          Length = 299

 Score =  185 bits (470), Expect = 3e-47,   Method: Composition-based stats.
 Identities = 62/283 (21%), Positives = 117/283 (41%), Gaps = 30/283 (10%)

Query: 21  REYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEK---VVVKILKPV---- 73
            E      HVV   +         +GRG +  V+    + N+ K     VK L  +    
Sbjct: 4   PELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIG 63

Query: 74  KKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTD--- 130
           +  +   E  I+++    PN+++L  I           V  ++ + D +   +  T    
Sbjct: 64  EVSQFLTEGIIMKDFSH-PNVLSLLGICLRSEGSPLV-VLPYMKHGDLRNFIRNETHNPT 121

Query: 131 -YDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYN 189
             D+  +  ++ K + Y  S   +HRD+   N M+D E   +++ D+GLA   H  + Y+
Sbjct: 122 VKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLD-EKFTVKVADFGLARDMHDKEYYS 180

Query: 190 VRVAS-----RYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYD---Q 241
           V   +       +   E L   Q +    D+WS G +L  ++ R  P +   + +D    
Sbjct: 181 VHNKTGAKLPVKWMALESLQT-QKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVY 239

Query: 242 LVRIAKVLGTE----DLYDYIDKY---NIELDPRFNDILGRHS 277
           L++  ++L  E     LY+ + K      E+ P F++++ R S
Sbjct: 240 LLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRIS 282


>4PL5-B nrPDB
          Length = 435

 Score =  185 bits (469), Expect = 3e-47,   Method: Composition-based stats.
 Identities = 70/328 (21%), Positives = 135/328 (41%), Gaps = 61/328 (18%)

Query: 21  REYWDYESHVVEWGNQDDYQLVRKLGRGKYSE-VFEAINITNNEKVVVKILKPVKKKKIK 79
           ++  D E+ +V  G    +     LG G     V++   + +N  V VK + P       
Sbjct: 12  QDDEDEETRMVIVGKIS-FCPKDVLGHGAEGTIVYKG--MFDNRDVAVKRILPECFSFAD 68

Query: 80  REIKILENLRGGPNIITLADIVKDPVSRTPALVF------EHVNNTDFKQLYQTLTDYDI 133
           RE+++L      PN+I      KD   +  A+        E+V   DF  L       + 
Sbjct: 69  REVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLG-----LEP 123

Query: 134 RFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEH--RKLR--LIDWGLAEFYHPGQEYN 189
              +++    L + HS+ I+HRD+KPHN+++   +   +++  + D+GL +    G+   
Sbjct: 124 ITLLHQTTSGLAHLHSLNIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSF 183

Query: 190 VRV----ASRYFKGPELLVDYQMY--DYSLDMWSLGCMLASMIF-RKEPFFHGHDNYDQL 242
            R      +  +  PE+L +       Y++D++S GC+   +I     PF         L
Sbjct: 184 SRRSGVPGTEGWIAPEMLSEDCKDNPTYTVDIFSAGCVFYYVISEGYHPF------GKSL 237

Query: 243 VRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLD 302
            R A +L      D                           F   +++ ++   A + ++
Sbjct: 238 QRQANILLGACNLDC--------------------------FHSDKHEDVI---ARELIE 268

Query: 303 KLLRYDHQSRLTAREAMEHPYFYTVVKD 330
           K++  D Q R +A+  ++HP+F+++ K 
Sbjct: 269 KMIAMDPQQRPSAKHVLKHPFFWSLEKQ 296


>2A1A-B nrPDB
          Length = 284

 Score =  184 bits (468), Expect = 5e-47,   Method: Composition-based stats.
 Identities = 57/291 (19%), Positives = 117/291 (40%), Gaps = 33/291 (11%)

Query: 27  ESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILE 86
            +H V+     D++ +  +G G + +VF+A +  + +  V+K +K    +K +RE+K L 
Sbjct: 1   GAHTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVK-YNNEKAEREVKALA 59

Query: 87  NLRGGPNIITLADIVKD--------------PVSRTPALVFEHVNNTDFKQLY-----QT 127
            L    NI+                        ++   +  E  +    +Q       + 
Sbjct: 60  KL-DHVNIVHYNGCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEK 118

Query: 128 LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE 187
           L          +I K +DY HS  +++RD+KP N+ +  + +++++ D+GL        +
Sbjct: 119 LDKVLALELFEQITKGVDYIHSKKLINRDLKPSNIFL-VDTKQVKIGDFGLVTSLKNDGK 177

Query: 188 YNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMI------FRKEPFFHGHDNYDQ 241
                 +  +  PE +   Q Y   +D+++LG +LA ++      F    FF   D  D 
Sbjct: 178 RTRSKGTLRYMSPEQI-SSQDYGKEVDLYALGLILAELLHVCDTAFETSKFF--TDLRDG 234

Query: 242 LVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHL 292
           ++        + L   +     E  P  ++IL   +   W++      +H 
Sbjct: 235 IISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTV--WKKSPEKNERHT 283


>4HVI-A nrPDB
          Length = 314

 Score =  184 bits (468), Expect = 5e-47,   Method: Composition-based stats.
 Identities = 47/205 (22%), Positives = 92/205 (44%), Gaps = 18/205 (8%)

Query: 38  DYQLVRKLGRGKYSEVFEAI----NITNNEKVVVKILK---PVKKKKIKREIKILENLRG 90
             + + +LG+G +  V               V VK L+   P +++  +REI+IL+ L  
Sbjct: 11  HLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKAL-H 69

Query: 91  GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----LTDYDIRFYMYEILKALDY 146
              I+    +   P  ++  LV E++ +   +   Q     L    +  Y  +I K ++Y
Sbjct: 70  SDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEY 129

Query: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRV----ASRYFKGPEL 202
             S   +HRD+   N++++ E   +++ D+GLA+     ++Y V      +  ++  PE 
Sbjct: 130 LGSRRCVHRDLAARNILVESEAH-VKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPES 188

Query: 203 LVDYQMYDYSLDMWSLGCMLASMIF 227
           L D  ++    D+WS G +L  +  
Sbjct: 189 LSD-NIFSRQSDVWSFGVVLYELFT 212


>1AD5-A nrPDB
          Length = 438

 Score =  184 bits (467), Expect = 6e-47,   Method: Composition-based stats.
 Identities = 42/283 (14%), Positives = 112/283 (39%), Gaps = 33/283 (11%)

Query: 17  THRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEA-INITNNEKVVVKILKP--V 73
           + +P++ W+ ++  +    ++  +L +KLG G++ EV+ A  N     KV VK +KP  +
Sbjct: 165 SSKPQKPWEKDAWEIP---RESLKLEKKLGAGQFGEVWMATYNKHT--KVAVKTMKPGSM 219

Query: 74  KKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ-----TL 128
             +    E  +++ L+    ++ L  +V         ++ E +         +       
Sbjct: 220 SVEAFLAEANVMKTLQHDK-LVKLHAVV---TKEPIYIITEFMAKGSLLDFLKSDEGSKQ 275

Query: 129 TDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEY 188
               +  +  +I + + +      +HRD++  N+++       ++ D+GLA         
Sbjct: 276 PLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSA-SLVCKIADFGLAR-------- 326

Query: 189 NVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRI 245
              V +++   +  PE + ++  +    D+WS G +L  ++      + G  N + +  +
Sbjct: 327 ---VGAKFPIKWTAPEAI-NFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRAL 382

Query: 246 AKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSE 288
            +        +  ++    +   + +         + + V  +
Sbjct: 383 ERGYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDD 425


>5X5O-A nrPDB
          Length = 310

 Score =  184 bits (466), Expect = 8e-47,   Method: Composition-based stats.
 Identities = 51/204 (25%), Positives = 93/204 (45%), Gaps = 19/204 (9%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIIT 96
           DD Q     G G +  V+ A  I+ +++V VK L      KI++E +IL  L    NII 
Sbjct: 15  DDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKL-----LKIEKEAEILSVLSH-RNIIQ 68

Query: 97  LADIVKDPVSRTPALVFEHVNNTDFKQLYQT-----LTDYDIRFYMYEILKALDYCHSM- 150
              ++ +P +    +V E+ +         +     +    I  +  ++ K + Y H   
Sbjct: 69  FYGVILEPPNYG--IVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEA 126

Query: 151 --GIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQM 208
              ++HRD+K  NV+I  +   L++ D+G A  +H    +   V +  +  PE++    +
Sbjct: 127 PVKVIHRDLKSRNVVIAADG-VLKICDFG-ASRFHNHTTHMSLVGTFPWMAPEVIQSLPV 184

Query: 209 YDYSLDMWSLGCMLASMIFRKEPF 232
              + D +S G +L  M+ R+ PF
Sbjct: 185 -SETCDTYSYGVVLWEMLTREVPF 207


>2PMN-X nrPDB
          Length = 348

 Score =  184 bits (466), Expect = 9e-47,   Method: Composition-based stats.
 Identities = 71/341 (20%), Positives = 141/341 (41%), Gaps = 68/341 (19%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPV--------------------KKK 76
           +DY+++R L +GK++++       +N+   +K  +                      K  
Sbjct: 31  NDYRIIRTLNQGKFNKIILCE--KDNKFYALKKYEKSLLEKKRDFTKSNNDKISIKSKYD 88

Query: 77  KIKREIKILENLRG-----GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTL--- 128
             K E++I+ +++         IIT  D           +++E++ N    +  +     
Sbjct: 89  DFKNELQIITDIKNEYCLTCEGIITNYD--------EVYIIYEYMENDSILKFDEYFFVL 140

Query: 129 --------TDYDIRFYMYEILKALDYCH-SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA 179
                       I+  +  +L +  Y H    I HRDVKP N+++D ++ +++L D+G +
Sbjct: 141 DKNYTCFIPIQVIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMD-KNGRVKLSDFGES 199

Query: 180 EFYHPGQEYNVRVASRYFKGPELLVDYQMY-DYSLDMWSLGCMLASMIFRKEPFFHGHDN 238
           E+    ++      +  F  PE   +   Y    +D+WSLG  L  M +   PF      
Sbjct: 200 EYMVD-KKIKGSRGTYEFMPPEFFSNESSYNGAKVDIWSLGICLYVMFYNVVPFS----- 253

Query: 239 YDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEAL 298
               ++I+ V    +L++ I   NIE     N  L   + K+      + + + +S E +
Sbjct: 254 ----LKISLV----ELFNNIRTKNIEYPLDRNHFLYPLTNKK-----STCSNNFLSNEDI 300

Query: 299 DFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSM 339
           DFL   LR +   R+T+ +A++H +      +  R  S  +
Sbjct: 301 DFLKLFLRKNPAERITSEDALKHEWLADTNIEDLREFSKEL 341


>4PDO-A nrPDB
          Length = 299

 Score =  183 bits (465), Expect = 1e-46,   Method: Composition-based stats.
 Identities = 51/290 (17%), Positives = 114/290 (39%), Gaps = 34/290 (11%)

Query: 18  HRPREYWDYESHVVEWGNQDD---YQLVRKLGRGKYSEVFEAINITNNEK----VVVKIL 70
             P  Y D    V+++  +         + +G G++ EV++ +  T++ K    V +K L
Sbjct: 12  QDPHTYEDPNQAVLKFTTEIHPSCVTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTL 71

Query: 71  KPVKKKK----IKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ 126
           K    +K       E  I+       NII L  ++     +   ++ E++ N    +  +
Sbjct: 72  KAGYTEKQRVDFLGEAGIMGQFSHH-NIIRLEGVISKY--KPMMIITEYMENGALDKFLR 128

Query: 127 T----LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFY 182
                 +   +   +  I   + Y  +M  +HRD+   N++++  +   ++ D+GL+   
Sbjct: 129 EKDGEFSVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNS-NLVCKVSDFGLSRVL 187

Query: 183 HPGQE--YNVRVA--SRYFKGPELLVDYQMYDYSLDMWSLGCMLAS-MIFRKEPFFH--G 235
               E  Y          +  PE +  Y+ +  + D+WS G ++   M + + P++    
Sbjct: 188 EDDPEATYTTSGGKIPIRWTAPEAI-SYRKFTSASDVWSFGIVMWEVMTYGERPYWELSN 246

Query: 236 HDNYDQLVRIAKVLGTEDLYDYIDKYNIEL-------DPRFNDILGRHSR 278
           H+    +    ++    D    I +  ++         P+F DI+    +
Sbjct: 247 HEVMKAINDGFRLPTPMDCPSAIYQLMMQCWQQERARRPKFADIVSILDK 296


>5KMM-A nrPDB
          Length = 329

 Score =  183 bits (464), Expect = 1e-46,   Method: Composition-based stats.
 Identities = 55/332 (16%), Positives = 118/332 (35%), Gaps = 75/332 (22%)

Query: 17  THRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINIT-----NNEKVVVKILK 71
              P+ + D   H ++   + D  L  +LG G + +VF A         +   V VK LK
Sbjct: 18  IENPQYFSDACVHHIK---RRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALK 74

Query: 72  PVK---KKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT- 127
                 ++  +RE ++L  L+   +I+    +  +   R   +VFE++ + D  +  ++ 
Sbjct: 75  EASESARQDFQREAELLTMLQHQ-HIVRFFGVCTE--GRPLLMVFEYMRHGDLNRFLRSH 131

Query: 128 -----------------LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRK 170
                            L    +     ++   + Y   +  +HRD+   N ++  +   
Sbjct: 132 GPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVG-QGLV 190

Query: 171 LRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIF 227
           +++ D+G++   +    Y V   +     +  PE ++ Y+ +    D+WS G +L  +  
Sbjct: 191 VKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESIL-YRKFTTESDVWSFGVVLWEIFT 249

Query: 228 -RKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVH 286
             K+P++               L   +  D I +      PR                  
Sbjct: 250 YGKQPWYQ--------------LSNTEAIDCITQGRELERPR------------------ 277

Query: 287 SENQHLVSPEALDFLDKLLRYDHQSRLTAREA 318
                   PE    +    + + Q R + ++ 
Sbjct: 278 -----ACPPEVYAIMRGCWQREPQQRHSIKDV 304


>4EUT-A nrPDB
          Length = 396

 Score =  183 bits (464), Expect = 1e-46,   Method: Composition-based stats.
 Identities = 63/349 (18%), Positives = 133/349 (38%), Gaps = 61/349 (17%)

Query: 41  LVRKLGRGKYSEVFEAINITNNEKVVVKI------LKPVKKKKIKREIKILENLRGGPNI 94
           L   LG+G  + VF   +    +   +K+      L+PV  +   RE ++L+ L    NI
Sbjct: 13  LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKL-NHKNI 69

Query: 95  ITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT------LTDYDIRFYMYEILKALDYCH 148
           + L  I ++  +R   L+ E         + +       L + +    + +++  +++  
Sbjct: 70  VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 129

Query: 149 SMGIMHRDVKPHNVM--IDHEHRKL-RLIDWGLAEFYHPGQEYNVRVASRYFKGPELLV- 204
             GI+HR++KP N+M  I  + + + +L D+G A      +++     +  +  P++   
Sbjct: 130 ENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYER 189

Query: 205 ------DYQMYDYSLDMWSLGCMLASMIFRKEPFFH---GHDNYDQLVRIA------KVL 249
                   + Y  ++D+WS+G           PF        N + + +I        + 
Sbjct: 190 AVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAIS 249

Query: 250 GTEDLYDYIDKYNIELD--------------PRFNDILGRHSRKRWERFVHSENQHLVSP 295
           G +   +    ++ ++               P   +IL     K W              
Sbjct: 250 GVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWG-------FDQFFA 302

Query: 296 EALDFLDKL-LRYDHQSRLTAREAMEHPY-----FYTVVKDQARMGSSS 338
           E  D L ++ +      ++TA +   H Y     F+ +V  Q ++ SS+
Sbjct: 303 ETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSN 351


>2RIO-A nrPDB
          Length = 434

 Score =  182 bits (463), Expect = 2e-46,   Method: Composition-based stats.
 Identities = 67/357 (18%), Positives = 123/357 (34%), Gaps = 73/357 (20%)

Query: 43  RKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVK 102
           + LG G    V           V VK +          EIK+L      PN+I       
Sbjct: 21  KILGYGSSGTVVF-QGSFQGRPVAVKRMLIDFCDIALMEIKLLTESDDHPNVIRYY--CS 77

Query: 103 DPVSRTPALVFEHVNNT--DF-------KQLYQTLTDYDIRFYMYEILKALDYCHSMGIM 153
           +   R   +  E  N    D         +  +   +Y+    + +I   + + HS+ I+
Sbjct: 78  ETTDRFLYIALELCNLNLQDLVESKNVSDENLKLQKEYNPISLLRQIASGVAHLHSLKII 137

Query: 154 HRDVKPHNVMIDH------------EHRKLRLIDWGLAEFYHPGQ-----EYNVRVASRY 196
           HRD+KP N+++              E+ ++ + D+GL +    GQ       N    +  
Sbjct: 138 HRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFRTNLNNPSGTSG 197

Query: 197 FKGPELLVDY------QMYDYSLDMWSLGCMLASMIF-RKEPFFHGHDNYDQLVRIAKVL 249
           ++ PELL +       +    S+D++S+GC+   ++   K PF    D Y +   I + +
Sbjct: 198 WRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPF---GDKYSRESNIIRGI 254

Query: 250 GTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDH 309
            + D    +                              +   +  EA D + +++ +D 
Sbjct: 255 FSLDEMKCL------------------------------HDRSLIAEATDLISQMIDHDP 284

Query: 310 QSRLTAREAMEHPYFYTVVKDQARM----GSSSMPGGSTPVSSANMMSGISSVPTPS 362
             R TA + + HP F+   K    +        +     P +        S    PS
Sbjct: 285 LKRPTAMKVLRHPLFWPKSKKLEFLLKVSDRLEIENRDPPSALLMKFDAGSDFVIPS 341


>5B2L-A nrPDB
          Length = 324

 Score =  182 bits (462), Expect = 2e-46,   Method: Composition-based stats.
 Identities = 55/315 (17%), Positives = 117/315 (37%), Gaps = 51/315 (16%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK----PVKKKKIKREIKILENLRGGP 92
           +D + + ++G G   +V++         + VK ++      + K+I  ++ ++      P
Sbjct: 17  NDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCP 76

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTL----TDYDIRFYMYEILKALDYC- 147
            I+          +    +  E +  T  ++L + +     +  +      I+KAL Y  
Sbjct: 77  YIVQCFGTF--ITNTDVFIAMELM-GTSAEKLKKRMQGPIPERILGKMTVAIVKALYYLK 133

Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLV--- 204
              G++HRDVKP N+++D E  +++L D+G++      +          +  PE +    
Sbjct: 134 EKHGVIHRDVKPSNILLD-ERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPD 192

Query: 205 -DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNI 263
                YD   D+WSLG  L  +   + P+ +   +++ L ++ +                
Sbjct: 193 PTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQ---------------- 236

Query: 264 ELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323
           E  P     +G                   S +   F+   L  DH+ R    + +EH +
Sbjct: 237 EEPPLLPGHMG------------------FSGDFQSFVKDCLTKDHRKRPKYNKLLEHSF 278

Query: 324 FYTVVKDQARMGSSS 338
                  +  + S  
Sbjct: 279 IKRYETLEVDVASWF 293


>4EUU-A nrPDB
          Length = 319

 Score =  182 bits (461), Expect = 3e-46,   Method: Composition-based stats.
 Identities = 46/249 (18%), Positives = 98/249 (39%), Gaps = 25/249 (10%)

Query: 41  LVRKLGRGKYSEVFEAINITNNEKVVVKI------LKPVKKKKIKREIKILENLRGGPNI 94
           L   LG+G  + VF   +    +   +K+      L+PV  +   RE ++L+ L    NI
Sbjct: 13  LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKL-NHKNI 69

Query: 95  ITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT------LTDYDIRFYMYEILKALDYCH 148
           + L  I ++  +R   L+ E         + +       L + +    + +++  +++  
Sbjct: 70  VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 129

Query: 149 SMGIMHRDVKPHNVM--IDHEHRKL-RLIDWGLAEFYHPGQEYNVRVASRYFKGPELLV- 204
             GI+HR++KP N+M  I  + + + +L D+G A      +++     +  +  P++   
Sbjct: 130 ENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYER 189

Query: 205 ------DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYI 258
                   + Y  ++D+WS+G           PF            + K++  +      
Sbjct: 190 AVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAIS 249

Query: 259 DKYNIELDP 267
                E  P
Sbjct: 250 GVQKAENGP 258


>3QGY-A nrPDB
          Length = 286

 Score =  182 bits (461), Expect = 3e-46,   Method: Composition-based stats.
 Identities = 43/260 (16%), Positives = 104/260 (40%), Gaps = 26/260 (10%)

Query: 35  NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK--PVKKKKIKREIKILENLRGGP 92
           +  +   V+++G G++  V     + N +KV +K +K   + +     E +++  L   P
Sbjct: 25  DPSELTFVQEIGSGQFGLVHLGYWL-NKDKVAIKTIKEGSMSEDDFIEEAEVMMKLSH-P 82

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----LTDYDIRFYMYEILKALDYCH 148
            ++ L  +  +       LVFE + +       +T         +     ++ + + Y  
Sbjct: 83  KLVQLYGVCLEQA--PICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLE 140

Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLVD 205
              ++HRD+   N ++  E++ +++ D+G+  F    Q Y     +++   +  PE+   
Sbjct: 141 EACVIHRDLAARNCLVG-ENQVIKVSDFGMTRFVLDDQ-YTSSTGTKFPVKWASPEVF-S 197

Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIA----------KVLGTEDLY 255
           +  Y    D+WS G ++  +    +  +    N + +  I+                 + 
Sbjct: 198 FSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIM 257

Query: 256 DYIDKYNIELDPRFNDILGR 275
           ++  K   E  P F+ +L +
Sbjct: 258 NHCWKERPEDRPAFSRLLRQ 277


>2PSQ-A nrPDB
          Length = 370

 Score =  182 bits (461), Expect = 3e-46,   Method: Composition-based stats.
 Identities = 47/275 (17%), Positives = 110/275 (40%), Gaps = 37/275 (13%)

Query: 36  QDDYQLVRKLGRGKYSEVFEA----INITNNEK---VVVKILKPVKKKK----IKREIKI 84
           +D   L + LG G + +V  A    I+    ++   V VK+LK    +K    +  E+++
Sbjct: 80  RDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEM 139

Query: 85  LENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----------------- 127
           ++ +    NII L             ++ E+ +  + ++  +                  
Sbjct: 140 MKMIGKHKNIINLLGACTQ--DGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPE 197

Query: 128 --LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPG 185
             +T  D+    Y++ + ++Y  S   +HRD+   NV++  E+  +++ D+GLA   +  
Sbjct: 198 EQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVT-ENNVMKIADFGLARDINNI 256

Query: 186 QEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQL 242
             Y      R    +  PE L D ++Y +  D+WS G ++  +       + G    +  
Sbjct: 257 DYYKKTTNGRLPVKWMAPEALFD-RVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELF 315

Query: 243 VRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHS 277
             + +    +   +  ++  + +   ++ +  +  
Sbjct: 316 KLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRP 350


>6O8B-A nrPDB
          Length = 665

 Score =  181 bits (460), Expect = 4e-46,   Method: Composition-based stats.
 Identities = 66/390 (16%), Positives = 143/390 (36%), Gaps = 65/390 (16%)

Query: 41  LVRKLGRGKYSEVFEAINITNNEKVVVKI------LKPVKKKKIKREIKILENLRGGPNI 94
           L   LG+G  + VF   +    +   +K+      L+PV  +   RE ++L+ L    NI
Sbjct: 19  LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKL-NHKNI 75

Query: 95  ITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT------LTDYDIRFYMYEILKALDYCH 148
           + L  I ++  +R   L+ E         + +       L + +    + +++  +++  
Sbjct: 76  VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 135

Query: 149 SMGIMHRDVKPHNVM--IDHEHRKL-RLIDWGLAEFYHPGQEYNVRVASRYFKGPELLV- 204
             GI+HR++KP N+M  I  + + + +L D+G A      +++     +  +  P++   
Sbjct: 136 ENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVELYGTEEYLHPDMYER 195

Query: 205 ------DYQMYDYSLDMWSLGCMLASMIFRKEPFFH---GHDNYDQLVRIA------KVL 249
                   + Y  ++D+WS+G           PF        N + + +I        + 
Sbjct: 196 AVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAIS 255

Query: 250 GTEDLYDYIDKYNIELD--------------PRFNDILGRHSRKRWERFVHSENQHLVSP 295
           G +   +    ++ ++               P   +IL     K W              
Sbjct: 256 GVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWG-------FDQFFA 308

Query: 296 EALDFLDKL-LRYDHQSRLTAREAMEHPY-----FYTVVKDQARMGSSSM----PGGSTP 345
           E  D L ++ +      ++TA +   H Y     F+ +V  Q ++ SS+      G    
Sbjct: 309 ETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLV 368

Query: 346 VSSANMMSGISSVPTPSPLGPLAGSPVIAA 375
           +    +          +P+  ++  P+   
Sbjct: 369 LEPGRLAQHFPKTTEENPIFVVSREPLDTI 398


>6NT9-A nrPDB
          Length = 742

 Score =  181 bits (460), Expect = 4e-46,   Method: Composition-based stats.
 Identities = 66/390 (16%), Positives = 143/390 (36%), Gaps = 65/390 (16%)

Query: 41  LVRKLGRGKYSEVFEAINITNNEKVVVKI------LKPVKKKKIKREIKILENLRGGPNI 94
           L   LG+G  + VF   +    +   +K+      L+PV  +   RE ++L+ L    NI
Sbjct: 11  LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKL-NHKNI 67

Query: 95  ITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT------LTDYDIRFYMYEILKALDYCH 148
           + L  I ++  +R   L+ E         + +       L + +    + +++  +++  
Sbjct: 68  VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 127

Query: 149 SMGIMHRDVKPHNVM--IDHEHRKL-RLIDWGLAEFYHPGQEYNVRVASRYFKGPELLV- 204
             GI+HR++KP N+M  I  + + + +L D+G A      +++     +  +  P++   
Sbjct: 128 ENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYER 187

Query: 205 ------DYQMYDYSLDMWSLGCMLASMIFRKEPFFH---GHDNYDQLVRIA------KVL 249
                   + Y  ++D+WS+G           PF        N + + +I        + 
Sbjct: 188 AVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAIS 247

Query: 250 GTEDLYDYIDKYNIELD--------------PRFNDILGRHSRKRWERFVHSENQHLVSP 295
           G +   +    ++ ++               P   +IL     K W              
Sbjct: 248 GVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWG-------FDQFFA 300

Query: 296 EALDFLDKL-LRYDHQSRLTAREAMEHPY-----FYTVVKDQARMGSSSM----PGGSTP 345
           E  D L ++ +      ++TA +   H Y     F+ +V  Q ++ SS+      G    
Sbjct: 301 ETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLV 360

Query: 346 VSSANMMSGISSVPTPSPLGPLAGSPVIAA 375
           +    +          +P+  ++  P+   
Sbjct: 361 LEPGRLAQHFPKTTEENPIFVVSREPLNTI 390


>5VO2-A nrPDB
          Length = 300

 Score =  181 bits (459), Expect = 6e-46,   Method: Composition-based stats.
 Identities = 46/239 (19%), Positives = 95/239 (39%), Gaps = 14/239 (5%)

Query: 45  LGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDP 104
           +G G    VF      + E+V VK ++ +K+  IK     L  L+  PNIIT   +    
Sbjct: 20  VGSGAQGAVFLGR--FHGEEVAVKKVRDLKETDIKH----LRKLKH-PNIITFKGVCTQ- 71

Query: 105 VSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHN 161
            +    ++ E        ++ +    +T   +  +   I   ++Y H   I+HRD+K  N
Sbjct: 72  -APCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPN 130

Query: 162 VMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCM 221
           ++I ++   +++ D+G ++             +  +  PE++ + +     +D+WS G +
Sbjct: 131 MLITYDD-VVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRN-EPVSEKVDIWSFGVV 188

Query: 222 LASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKR 280
           L  ++  + P+     +       +  L         D + I L   +N         R
Sbjct: 189 LWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFR 247


>6FEX-A nrPDB
          Length = 321

 Score =  180 bits (458), Expect = 7e-46,   Method: Composition-based stats.
 Identities = 56/289 (19%), Positives = 108/289 (37%), Gaps = 52/289 (17%)

Query: 36  QDDYQLVRKLGRGKYSEVFEA----------------INITNNEKVVVKILKPVKKK--- 76
           +   +   KLG G++ EV                   +   +   V VKIL+P   K   
Sbjct: 15  RSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNAR 74

Query: 77  -KIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ--------- 126
               +E+KI+  L+  PNII L  +          ++ +++ N D  Q            
Sbjct: 75  NDFLKEVKIMSRLKD-PNIIRLLGVC--VQDDPLCMITDYMENGDLNQFLSAHQLEDKAA 131

Query: 127 -------TLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA 179
                  T++   +     +I   + Y  ++  +HRD+   N ++  E+  +++ D+G++
Sbjct: 132 EGAPGDPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVG-ENFTIKIADFGMS 190

Query: 180 EFYHPGQEYNVR---VASRYFKGPELLVDYQMYDYSLDMWSLGCMLAS--MIFRKEPFFH 234
              + G  Y V+   V    +   E ++    +  + D+W+ G  L    M+ R +PF  
Sbjct: 191 RNLYAGDYYRVQGRAVLPIRWMAWECIL-MGKFTTASDVWAFGVTLWEVLMLCRAQPFGQ 249

Query: 235 GHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWER 283
             D      ++ +  G E   D   +  +   P     L     + W R
Sbjct: 250 LTDE-----QVIENAG-EFFRDQGRQVYLSRPPACPQGLYELMLRCWSR 292


>4K33-A nrPDB
          Length = 325

 Score =  180 bits (456), Expect = 1e-45,   Method: Composition-based stats.
 Identities = 56/287 (19%), Positives = 108/287 (37%), Gaps = 47/287 (16%)

Query: 35  NQDDYQLVRKLGRGKYSEVFEA----INITNNEK---VVVKILKPVKKKK----IKREIK 83
           ++    L + LG G + +V  A    I+     K   V VK+LK     K    +  E++
Sbjct: 34  SRARLTLGKPLGEGAFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEME 93

Query: 84  ILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---------------- 127
           +++ +    NII L             ++ E+    + ++  +                 
Sbjct: 94  MMKMIGKHKNIINLLGACTQ--GGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTSKPP 151

Query: 128 ---LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHP 184
              LT  D+    Y++ + ++Y  S   +HRD+   NV++  ++  +++ D+GLA   H 
Sbjct: 152 EEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDN-VMKIADFGLARDVHN 210

Query: 185 GQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQ 241
              Y      R    +  PE L D ++Y +  D+WS G +L  +       + G    + 
Sbjct: 211 LDYYKETTNGRLPVKWMAPEALFD-RVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEEL 269

Query: 242 LVRIAK-------VLGTEDLYDYIDKY---NIELDPRFNDILGRHSR 278
              + +          T DLY  + +         P F  ++    R
Sbjct: 270 FKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDR 316


>5EG3-A nrPDB
          Length = 334

 Score =  179 bits (454), Expect = 2e-45,   Method: Composition-based stats.
 Identities = 50/303 (16%), Positives = 117/303 (38%), Gaps = 38/303 (12%)

Query: 36  QDDYQLVRKLGRGKYSEVFEA----INITNNEK---VVVKILKPVKKKK----IKREIKI 84
           +D   L + LG G + +V  A    I+    ++   V VK+LK    +K    +  E+++
Sbjct: 34  RDKLTLGKPLGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEM 93

Query: 85  LENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----------------- 127
           ++ +    NII L             ++  + +  + ++  +                  
Sbjct: 94  MKMIGKHKNIINLLGACTQ--DGPLYVIVAYASKGNLREYLRARRPPGMELSPDINRVPE 151

Query: 128 --LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPG 185
             +T  D+    Y++ + ++Y  S   +HRD+   NV++  E+  +++ D+GLA   +  
Sbjct: 152 EQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVT-ENNVMKIADFGLARDINNI 210

Query: 186 QEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQL 242
             +      R    +  PE L D ++Y +  D+WS G ++  +       + G    +  
Sbjct: 211 DFFKETTNGRLPVKWMAPEALFD-RVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELF 269

Query: 243 VRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSR-KRWERFVHSENQHLVSPEALDFL 301
             + +    +   +  ++  + +   ++ +  +    K+    +        + E LD  
Sbjct: 270 KLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLS 329

Query: 302 DKL 304
             L
Sbjct: 330 QPL 332


>3KUL-B nrPDB
          Length = 325

 Score =  179 bits (453), Expect = 2e-45,   Method: Composition-based stats.
 Identities = 54/299 (18%), Positives = 114/299 (38%), Gaps = 27/299 (9%)

Query: 19  RPREYWDYESHVVEWGNQ---DDYQLVRKLGRGKYSEVFEAINITNNEK---VVVKILKP 72
            P  Y +       +  +       + + +G G   EV         ++   V +K LK 
Sbjct: 28  EPHTYEEPGRAGRSFTREIEASRIHIEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKA 87

Query: 73  VKKKKIKR----EIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT- 127
              ++ +R    E  I+      PNII L  +V     R   +V E++ N       +T 
Sbjct: 88  GYTERQRRDFLSEASIMGQF-DHPNIIRLEGVVTR--GRLAMIVTEYMENGSLDTFLRTH 144

Query: 128 ---LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHP 184
               T   +   +  +   + Y   +G +HRD+   NV++D  +   ++ D+GL+     
Sbjct: 145 DGQFTIMQLVGMLRGVGAGMRYLSDLGYVHRDLAARNVLVDS-NLVCKVSDFGLSRVLED 203

Query: 185 GQE--YNVRVA--SRYFKGPELLVDYQMYDYSLDMWSLGCMLAS-MIFRKEPFFHGHDNY 239
             +  Y          +  PE +  ++ +  + D+WS G ++   + + + P+++   N 
Sbjct: 204 DPDAAYTTTGGKIPIRWTAPEAIA-FRTFSSASDVWSFGVVMWEVLAYGERPYWN-MTNR 261

Query: 240 DQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEAL 298
           D +  + +              +  +   ++    R  R R+ + V   +  + SPE+L
Sbjct: 262 DVISSVEEGYRLPAPMGCPHALHQLMLDCWHK--DRAQRPRFSQIVSVLDALIRSPESL 318


>4XCU-A nrPDB
          Length = 300

 Score =  179 bits (453), Expect = 3e-45,   Method: Composition-based stats.
 Identities = 56/289 (19%), Positives = 108/289 (37%), Gaps = 42/289 (14%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAI-------NITNNEKVVVKILKPVKKKK----IKREIKI 84
           +D   L + LG G + +V  A               V VK+LK     K    +  E+++
Sbjct: 16  RDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEV 75

Query: 85  LENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----------LTDYDIR 134
           ++ +    NII L  +          ++ E     + ++  +           L+   + 
Sbjct: 76  MKLIGRHKNIINLLGVCTQEG--PLYVIVECAAKGNLREFLRARRPPGSSEGPLSFPVLV 133

Query: 135 FYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVAS 194
              Y++ + + Y  S   +HRD+   NV++  ++  +++ D+GLA   H    Y      
Sbjct: 134 SCAYQVARGMQYLESRKCIHRDLAARNVLVTEDN-VMKIADFGLARGVHHIDYYKKTSNG 192

Query: 195 RY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGT 251
           R    +  PE L D ++Y +  D+WS G +L  +       + G             +  
Sbjct: 193 RLPVKWMAPEALFD-RVYTHQSDVWSFGILLWEIFTLGGSPYPG-------------IPV 238

Query: 252 EDLYDYIDK-YNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALD 299
           E+L+  + + + ++  P     L    R+ W              EALD
Sbjct: 239 EELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALD 287


>6BSD-A nrPDB
          Length = 876

 Score =  178 bits (452), Expect = 3e-45,   Method: Composition-based stats.
 Identities = 56/295 (18%), Positives = 108/295 (36%), Gaps = 58/295 (19%)

Query: 36  QDDYQLVRKLGRGKYSEVFEA----------------INITNNEKVVVKILKPVKKK--- 76
           +   +   KLG G++ EV                   +   +   V VKIL+P   K   
Sbjct: 570 RSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNAR 629

Query: 77  -KIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ--------- 126
               +E+KI+  L+  PNII L  +          ++ +++ N D  Q            
Sbjct: 630 NDFLKEVKIMSRLKD-PNIIRLLGVC--VQDDPLCMITDYMENGDLNQFLSAHQLEDKAA 686

Query: 127 -------------TLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRL 173
                        T++   +     +I   + Y  ++  +HRD+   N ++  E+  +++
Sbjct: 687 EGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVG-ENFTIKI 745

Query: 174 IDWGLAEFYHPGQEYNVR---VASRYFKGPELLVDYQMYDYSLDMWSLGCMLAS--MIFR 228
            D+G++   + G  Y V+   V    +   E ++    +  + D+W+ G  L    M+ R
Sbjct: 746 ADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECIL-MGKFTTASDVWAFGVTLWEVLMLCR 804

Query: 229 KEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWER 283
            +PF    D      ++ +  G E   D   +  +   P     L     + W R
Sbjct: 805 AQPFGQLTDE-----QVIENAG-EFFRDQGRQVYLSRPPACPQGLYELMLRCWSR 853


>4M7I-A nrPDB
          Length = 299

 Score =  178 bits (451), Expect = 5e-45,   Method: Composition-based stats.
 Identities = 49/248 (19%), Positives = 105/248 (42%), Gaps = 39/248 (15%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK----PVKKKKIKREIKILENLRGGPN 93
           D++ ++ LGRG +  VFEA N  ++    +K ++     + ++K+ RE+K L  L   P 
Sbjct: 6   DFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEH-PG 64

Query: 94  IITLADIVKDPVSR----------TPALVFEHVNNTDFKQLYQ---TLTDYD---IRFYM 137
           I+   +   +  +              +  +     + K       T+ + +        
Sbjct: 65  IVRYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIF 124

Query: 138 YEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE---------- 187
            +I +A+++ HS G+MHRD+KP N+    +   +++ D+GL       +E          
Sbjct: 125 LQIAEAVEFLHSKGLMHRDLKPSNIFFTMDD-VVKVGDFGLVTAMDQDEEEQTVLTPMPA 183

Query: 188 ---YNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVR 244
              +  +V ++ +  PE +     Y + +D++SLG +L  +++   PF    +    L  
Sbjct: 184 YARHTGQVGTKLYMSPEQIHGNS-YSHKVDIFSLGLILFELLY---PFSTQMERVRTLTD 239

Query: 245 IAKVLGTE 252
           +  +    
Sbjct: 240 VRNLKFPP 247


>4XLV-A nrPDB
          Length = 328

 Score =  178 bits (451), Expect = 5e-45,   Method: Composition-based stats.
 Identities = 63/352 (17%), Positives = 123/352 (34%), Gaps = 75/352 (21%)

Query: 7   SRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFE--AINITNNE- 63
           S    Y   +   P   +  +   V   +++   L+R+LG+G +  V+E  A +I   E 
Sbjct: 12  SSNPEYLSASDVFPSSVYVPDEWEV---SREKITLLRELGQGSFGMVYEGNARDIIKGEA 68

Query: 64  --KVVVKILKPV----KKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVN 117
             +V VK +       ++ +   E  +++      +++ L  +V     +   +V E + 
Sbjct: 69  ETRVAVKTVNESASLRERIEFLNEASVMKGFTCH-HVVRLLGVV--SKGQPTLVVMELMA 125

Query: 118 NTDFKQLYQTLTDY-------------DIRFYMYEILKALDYCHSMGIMHRDVKPHNVMI 164
           + D K   ++L                ++     EI   + Y ++   +HRD+   N M+
Sbjct: 126 HGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMV 185

Query: 165 DHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCM 221
            H+   +++ D+G+    +    Y           +  PE L D  ++  S DMWS G +
Sbjct: 186 AHD-FTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKD-GVFTTSSDMWSFGVV 243

Query: 222 LASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRW 281
           L  +    E  + G  N +Q+++     G  D  D                         
Sbjct: 244 LWEITSLAEQPYQGLSN-EQVLKFVMDGGYLDQPDNC----------------------- 279

Query: 282 ERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAME------HPYFYTV 327
                            D +    +++   R T  E +       HP F  V
Sbjct: 280 ------------PERVTDLMRMCWQFNPNMRPTFLEIVNLLKDDLHPSFPEV 319


>4IDT-A nrPDB
          Length = 356

 Score =  177 bits (450), Expect = 5e-45,   Method: Composition-based stats.
 Identities = 55/233 (23%), Positives = 92/233 (39%), Gaps = 25/233 (10%)

Query: 15  VNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK 74
               +P +Y   E   V W        +R LGRG + EV    +     +  VK ++   
Sbjct: 59  TEKLKPVDYEYRE--EVHWATHQ----LR-LGRGSFGEVHRMEDKQTGFQCAVKKVRLEV 111

Query: 75  KKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ---TLTDY 131
            +    E+     L   P I+ L   V++       +  E +      QL +    L + 
Sbjct: 112 FRA--EELMACAGLT-SPRIVPLYGAVRE--GPWVNIFMELLEGGSLGQLVKEQGCLPED 166

Query: 132 DIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVR 191
              +Y+ + L+ L+Y HS  I+H DVK  NV++  +     L D+G A    P       
Sbjct: 167 RALYYLGQALEGLEYLHSRRILHGDVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKDL 226

Query: 192 V------ASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEP---FFHG 235
           +       +     PE+++  +  D  +D+WS  CM+  M+    P   FF G
Sbjct: 227 LTGDYIPGTETHMAPEVVLG-RSCDAKVDVWSSCCMMLHMLNGCHPWTQFFRG 278


>6E4F-A nrPDB
          Length = 290

 Score =  177 bits (450), Expect = 5e-45,   Method: Composition-based stats.
 Identities = 47/262 (17%), Positives = 111/262 (42%), Gaps = 28/262 (10%)

Query: 35  NQDDYQLVRKLGRGKYSEVFEAINITNNEK-VVVKILK--PVKKKKIKREIKILENLRGG 91
           +  D   +++LG G++  V         +  V +K++K   + + +   E K++ NL   
Sbjct: 29  DPKDLTFLKELGTGQFGVVKYGKWR--GQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHE 86

Query: 92  PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDY----DIRFYMYEILKALDYC 147
             ++ L  +      R   ++ E++ N       + +        +     ++ +A++Y 
Sbjct: 87  K-LVQLYGVCTKQ--RPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYL 143

Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLV 204
            S   +HRD+   N +++ +   +++ D+GL+ +     EY   V S++   +  PE+L+
Sbjct: 144 ESKQFLHRDLAARNCLVN-DQGVVKVSDFGLSRYVLDD-EYTSSVGSKFPVRWSPPEVLM 201

Query: 205 DYQMYDYSLDMWSLGCMLASMIF-RKEPF--FHGHDNYDQLVRIAKV----LGTEDLYDY 257
            Y  +    D+W+ G ++  +    K P+  F   +  + + +  ++    L +E +Y  
Sbjct: 202 -YSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTI 260

Query: 258 IDKYNIE---LDPRFNDILGRH 276
           +     E     P F  +L   
Sbjct: 261 MYSCWHEKADERPTFKILLSNI 282


>3UIU-A nrPDB
          Length = 306

 Score =  177 bits (450), Expect = 6e-45,   Method: Composition-based stats.
 Identities = 58/303 (19%), Positives = 118/303 (38%), Gaps = 46/303 (15%)

Query: 29  HVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENL 88
           + V+     D++ +  +G G + +VF+A +  + +  V++ +K    +K +RE+K L  L
Sbjct: 4   YTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIRRVK-YNNEKAEREVKALAKL 62

Query: 89  RGGPNIITLADIVK------------------DPVS---------RTPALVFEHVNNTDF 121
               NI+                         DP +         +   +  E  +    
Sbjct: 63  -DHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTL 121

Query: 122 KQLY-----QTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDW 176
           +Q       + L          +I K +DY HS  ++HRD+KP N+ +  + +++++ D+
Sbjct: 122 EQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFL-VDTKQVKIGDF 180

Query: 177 GLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMI------FRKE 230
           GL        +      +  +  PE +   Q Y   +D+++LG +LA ++      F   
Sbjct: 181 GLVTSLKNDGKRTRSKGTLRYMSPEQI-SSQDYGKEVDLYALGLILAELLHVCDTAFETS 239

Query: 231 PFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQ 290
            FF   D  D ++        + L   +     E  P  ++IL   +   W++      +
Sbjct: 240 KFF--TDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTV--WKKSPEKNER 295

Query: 291 HLV 293
           H  
Sbjct: 296 HTC 298


>3SXS-A nrPDB
          Length = 268

 Score =  177 bits (449), Expect = 7e-45,   Method: Composition-based stats.
 Identities = 40/261 (15%), Positives = 110/261 (42%), Gaps = 25/261 (9%)

Query: 35  NQDDYQLVRKLGRGKYSEVFEAINITNNEK-VVVKILK--PVKKKKIKREIKILENLRGG 91
            +++  L+++LG G++  V         +  V VK++K   + + +  +E + +  L   
Sbjct: 6   KREEITLLKELGSGQFGVVKLGKWK--GQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSH- 62

Query: 92  PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----LTDYDIRFYMYEILKALDYC 147
           P ++    +          +V E+++N       ++    L    +    Y++ + + + 
Sbjct: 63  PKLVKFYGVC--SKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFL 120

Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLV 204
            S   +HRD+   N ++D +   +++ D+G+  +    Q Y   V +++   +  PE+  
Sbjct: 121 ESHQFIHRDLAARNCLVDRD-LCVKVSDFGMTRYVLDDQ-YVSSVGTKFPVKWSAPEVFH 178

Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKV-------LGTEDLYDY 257
            ++ Y    D+W+ G ++  +    +  +  + N + ++++++        L ++ +Y  
Sbjct: 179 YFK-YSSKSDVWAFGILMWEVFSLGKMPYDLYTNSEVVLKVSQGHRLYRPHLASDTIYQI 237

Query: 258 IDKYNIELDPRFNDILGRHSR 278
           +     EL  +        S 
Sbjct: 238 MYSCWHELPEKRPTFQQLLSS 258


>6CTH-A nrPDB
          Length = 309

 Score =  177 bits (449), Expect = 7e-45,   Method: Composition-based stats.
 Identities = 57/247 (23%), Positives = 106/247 (42%), Gaps = 21/247 (8%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIK---REIKILENLRGGPNI 94
           ++    KLG G +  V+      ++  + VK +    K+ IK    E+KI+  LR   N+
Sbjct: 16  NFNAENKLGEGGFGSVYRGFLRDSDTYIAVKKVSRASKQGIKEYASEVKIISRLRH-KNL 74

Query: 95  ITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRF-YMYEILKALDYCHSM 150
           + L     +       LV+E + N          ++L  +++R+  + ++  AL Y H  
Sbjct: 75  VKLIGWCHERGE--LMLVYEFMANGSLDSHIFKGKSLLTWEVRYRIVKDLASALLYLHEE 132

Query: 151 G---IMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHP--GQEYNVRVASRYFKGPELLVD 205
           G   ++HRD+K  N+M+D      +L D+GLA       G +  +   +  +  PE L  
Sbjct: 133 GDHCVLHRDIKTSNIMLDS-SFNAKLGDFGLARLVDHAKGLKKTLLAGTVGYMAPECLSS 191

Query: 206 YQMYDYSLDMWSLGCMLASMIFRK---EPFFHGHDNYDQLVRIAKVLGTEDLYDYID-KY 261
            +      D++S G +   +   +   EP F   +    +  + +  G E + D  D K 
Sbjct: 192 GKA-SKESDVYSFGVVALEIASGRRSIEPKFEESEALLLVPWVWESYGNERILDIADRKL 250

Query: 262 NIELDPR 268
            +  DP+
Sbjct: 251 GMAFDPK 257


>4Y83-A nrPDB
          Length = 332

 Score =  177 bits (449), Expect = 8e-45,   Method: Composition-based stats.
 Identities = 59/338 (17%), Positives = 123/338 (36%), Gaps = 51/338 (15%)

Query: 3   GPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLG-----RGKYSEVFEAI 57
           G  P  + +  ++        +  +S V+    +  Y   R +G     RG + +V+ A 
Sbjct: 37  GQRPQESGILLNMVITPQNGRYQIDSDVLLIPWKLTY---RNIGSDFIPRGAFGKVYLAQ 93

Query: 58  NITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVN 117
           +I   +++  K++   + K    EI+         NI  L   V      T  L  E   
Sbjct: 94  DIKTKKRMACKLIPVDQFKPSDVEIQA---CFRHENIAELYGAV--LWGETVHLFMEAGE 148

Query: 118 NTDFKQLYQT---LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLI 174
                +  ++   + +++I +    +LK LD+ HS  ++H D+KP N++         L+
Sbjct: 149 GGSVLEKLESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHHDIKPSNIVFMSTKAV--LV 206

Query: 175 DWGLAEFYHPGQEY-NVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFF 233
           D+GL+        +      +  +  PE+++  + +    D++SLG  L  M     P  
Sbjct: 207 DFGLSVQMTEDVYFPKDLRGTEIYMSPEVIL-CRGHSTKADIYSLGATLIHMQTGTPP-- 263

Query: 234 HGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLV 293
                                  ++ +Y     P +  I+ + +          +     
Sbjct: 264 -----------------------WVKRYPRSAYPSYLYIIHKQAPP------LEDIADDC 294

Query: 294 SPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQ 331
           SP   + ++  L  +   R  A + ++H       +DQ
Sbjct: 295 SPGMRELIEASLERNPNHRPRAADLLKHEALNPPREDQ 332


>4XI2-A nrPDB
          Length = 446

 Score =  176 bits (447), Expect = 1e-44,   Method: Composition-based stats.
 Identities = 46/262 (17%), Positives = 111/262 (42%), Gaps = 28/262 (10%)

Query: 35  NQDDYQLVRKLGRGKYSEVFEAINITNNEK-VVVKILK--PVKKKKIKREIKILENLRGG 91
           +  D   +++LG G++  V         +  V +K+++   + + +   E K++ NL   
Sbjct: 185 DPKDLTFLKELGTGQFGVVKYGKWR--GQYDVAIKMIREGSMSEDEFIEEAKVMMNLSHE 242

Query: 92  PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDY----DIRFYMYEILKALDYC 147
             ++ L  +      R   ++ E++ N       + +        +     ++ +A++Y 
Sbjct: 243 K-LVQLYGVCTKQ--RPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYL 299

Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLV 204
            S   +HRD+   N +++ +   +++ D+GL+ +     EY   V S++   +  PE+L+
Sbjct: 300 ESKQFLHRDLAARNCLVN-DQGVVKVSDFGLSRYVLDD-EYTSSVGSKFPVRWSPPEVLM 357

Query: 205 DYQMYDYSLDMWSLGCMLASMIF-RKEPF--FHGHDNYDQLVRIAKV----LGTEDLYDY 257
            Y  +    D+W+ G ++  +    K P+  F   +  + + +  ++    L +E +Y  
Sbjct: 358 -YSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASERVYTI 416

Query: 258 IDKYNIE---LDPRFNDILGRH 276
           +     E     P F  +L   
Sbjct: 417 MYSCWHEKADERPSFKILLSNI 438


>2WTK-B nrPDB
          Length = 373

 Score =  176 bits (446), Expect = 2e-44,   Method: Composition-based stats.
 Identities = 69/358 (19%), Positives = 126/358 (35%), Gaps = 41/358 (11%)

Query: 39  YQLVRKLGRGKYS---EVFEAINITNNEKVVVKILKPVKKKK-----IKREIKILENLRG 90
           Y+L+  +G+G +     V  A      E V V+ +            ++ E+ +   L  
Sbjct: 11  YELLTVIGKG-FEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHV-SKLFN 68

Query: 91  GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY-----QTLTDYDIRFYMYEILKALD 145
            PNI+               +V   +     K L        + +  I + +  +LKALD
Sbjct: 69  HPNIVPYRATF--IADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALD 126

Query: 146 YCHSMGIMHRDVKPHNVMIDHEHR--------KLRLIDWGLA-EFYHPGQEYNVRVASRY 196
           Y H MG +HR VK  +++I  + +         L +I  G      H   +Y+V+V    
Sbjct: 127 YIHHMGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSVKV--LP 184

Query: 197 FKGPELL-VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLY 255
           +  PE+L  + Q YD   D++S+G     +     PF         L ++   +      
Sbjct: 185 WLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPCLLDT 244

Query: 256 DYIDKYNIELDPRFN--------DILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRY 307
             I    + + P  +         +     R               SP    F+++ L+ 
Sbjct: 245 STIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTFSPHFHHFVEQCLQR 304

Query: 308 DHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLG 365
           +  +R +A   + H +F  + +      S ++P    PV+      G  S       G
Sbjct: 305 NPDARPSASTLLNHSFFKQIKRR----ASEALPELLRPVTPITNFEGSQSQDHSGIFG 358


>4LRM-A nrPDB
          Length = 334

 Score =  175 bits (445), Expect = 2e-44,   Method: Composition-based stats.
 Identities = 58/311 (18%), Positives = 132/311 (42%), Gaps = 37/311 (11%)

Query: 26  YESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKV----VVKILK----PVKKKK 77
               ++    + +++ ++ LG G +  V++ + I   EKV     +K L+    P   K+
Sbjct: 8   PNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKE 67

Query: 78  IKREIKILENLRG--GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----LTDY 131
           I  E  ++ ++     P++  L  I    ++ T  L+ + +         +     +   
Sbjct: 68  ILDEAYVMASVDNPGNPHVCRLLGIC---LTSTVQLITQLMPFGCLLDYVREHKDNIGSQ 124

Query: 132 DIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFY-HPGQEYNV 190
            +  +  +I K ++Y     ++HRD+   NV++    + +++ D+GLA+      +EY+ 
Sbjct: 125 YLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTP-QHVKITDFGLAKLLGAEEKEYHA 183

Query: 191 RVASRY--FKGPELLVDYQMYDYSLDMWSLGCMLAS-MIFRKEPF--FHGHDNYDQLVRI 245
                   +   E ++ +++Y +  D+WS G  +   M F  +P+      +    L + 
Sbjct: 184 EGGKVPIKWMALESIL-HRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKG 242

Query: 246 AKV----LGTEDLYDYIDKYNI---ELDPRFNDILGRHSR-----KRWERFVHSENQHLV 293
            ++    + T D+Y  + K  +   +  P+F +++   S+     +R+      E  HL 
Sbjct: 243 ERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLP 302

Query: 294 SPEALDFLDKL 304
           SP   +F   L
Sbjct: 303 SPTDSNFYRAL 313


>1LUF-A nrPDB
          Length = 343

 Score =  175 bits (445), Expect = 2e-44,   Method: Composition-based stats.
 Identities = 46/261 (17%), Positives = 98/261 (37%), Gaps = 50/261 (19%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNN-------EKVVVKILKPV----KKKKIKREIKI 84
           +++ + VR +G G +  VF+A               V VK+LK       +   +RE  +
Sbjct: 46  RNNIEYVRDIGEGAFGRVFQAR--APGLLPYEPFTMVAVKMLKEEASADMQADFQREAAL 103

Query: 85  LENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDI----------- 133
           +      PNI+ L  +    V +   L+FE++   D  +  ++++ + +           
Sbjct: 104 MAEFDN-PNIVKLLGVC--AVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTR 160

Query: 134 ----------------RFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWG 177
                                ++   + Y      +HRD+   N ++  E+  +++ D+G
Sbjct: 161 ARVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVG-ENMVVKIADFG 219

Query: 178 LAEFYHPGQEYNVRVA---SRYFKGPELLVDYQMYDYSLDMWSLGCMLASMI-FRKEPFF 233
           L+   +    Y           +  PE +  Y  Y    D+W+ G +L  +  +  +P++
Sbjct: 220 LSRNIYSADYYKADGNDAIPIRWMPPESIF-YNRYTTESDVWAYGVVLWEIFSYGLQPYY 278

Query: 234 H-GHDNYDQLVRIAKVLGTED 253
              H+     VR   +L   +
Sbjct: 279 GMAHEEVIYYVRDGNILACPE 299


>5GNK-A nrPDB
          Length = 297

 Score =  175 bits (443), Expect = 4e-44,   Method: Composition-based stats.
 Identities = 50/278 (17%), Positives = 121/278 (43%), Gaps = 31/278 (11%)

Query: 26  YESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKV----VVKILK----PVKKKK 77
               ++    + +++ ++ LG G +  V++ + I   EKV     +K L+    P   K+
Sbjct: 8   PNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKE 67

Query: 78  IKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----LTDYDI 133
           I  E  ++ ++   P++  L  I    ++ T  L+ + +         +     +    +
Sbjct: 68  ILDEAYVMASVDN-PHVCRLLGIC---LTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYL 123

Query: 134 RFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFY-HPGQEYNVRV 192
             +  +I K ++Y     ++HRD+   NV++    + +++ D+GLA+      +EY+   
Sbjct: 124 LNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTP-QHVKITDFGLAKLLGAEEKEYHAEG 182

Query: 193 ASRY--FKGPELLVDYQMYDYSLDMWSLGCMLAS-MIFRKEPF--FHGHDNYDQLVRIAK 247
                 +   E ++ +++Y +  D+WS G  +   M F  +P+      +    L +  +
Sbjct: 183 GKVPIKWMALESIL-HRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGER 241

Query: 248 V----LGTEDLYDYIDKYNI---ELDPRFNDILGRHSR 278
           +    + T D+Y  + K  +   +  P+F +++   S+
Sbjct: 242 LPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSK 279


>1U59-A nrPDB
          Length = 287

 Score =  174 bits (441), Expect = 6e-44,   Method: Composition-based stats.
 Identities = 44/263 (16%), Positives = 105/263 (39%), Gaps = 30/263 (11%)

Query: 44  KLGRGKYSEVFEAINITNNEK--VVVKILK----PVKKKKIKREIKILENLRGGPNIITL 97
           +LG G +  V + +     ++  V +K+LK        +++ RE +I+  L   P I+ L
Sbjct: 17  ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDN-PYIVRL 75

Query: 98  ADIVKDPVSRTPALVFEHVNNTDFKQLY----QTLTDYDIRFYMYEILKALDYCHSMGIM 153
             + +   +    LV E        +      + +   ++   ++++   + Y      +
Sbjct: 76  IGVCQ---AEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFV 132

Query: 154 HRDVKPHNVMIDHEHRKLRLIDWGLAEFY-HPGQEYNVRVASRY---FKGPELLVDYQMY 209
           HRD+   NV++ + H   ++ D+GL++        Y  R A ++   +  PE + +++ +
Sbjct: 133 HRDLAARNVLLVNRHYA-KISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI-NFRKF 190

Query: 210 DYSLDMWSLGCMLAS-MIFRKEPF--FHGHDNYDQLVRIAKVLGTEDLYDYIDK------ 260
               D+WS G  +   + + ++P+    G +    + +  ++    +    +        
Sbjct: 191 SSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCW 250

Query: 261 -YNIELDPRFNDILGRHSRKRWE 282
            Y  E  P F  +  R     + 
Sbjct: 251 IYKWEDRPDFLTVEQRMRACYYS 273


>4G3E-A nrPDB
          Length = 352

 Score =  174 bits (440), Expect = 8e-44,   Method: Composition-based stats.
 Identities = 48/227 (21%), Positives = 90/227 (39%), Gaps = 22/227 (9%)

Query: 15  VNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK 74
               +P +Y   E   V W          ++GRG + EV    +     +  VK ++   
Sbjct: 59  TEKLKPVDYEYRE--EVHWMTHQP-----RVGRGSFGEVHRMKDKQTGFQCAVKKVR--- 108

Query: 75  KKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ---TLTDY 131
            +  + E  +       P I+ L   V++       +  E +      QL +    L + 
Sbjct: 109 LEVFRVEELVACAGLSSPRIVPLYGAVRE--GPWVNIFMELLEGGSLGQLIKQMGCLPED 166

Query: 132 DIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVR 191
              +Y+ + L+ L+Y H+  I+H DVK  NV++  +  +  L D+G A    P       
Sbjct: 167 RALYYLGQALEGLEYLHTRRILHGDVKADNVLLSSDGSRAALCDFGHALCLQPDGLGKSL 226

Query: 192 V------ASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPF 232
           +       +     PE+++  +  D  +D+WS  CM+  M+    P+
Sbjct: 227 LTGDYIPGTETHMAPEVVMG-KPCDAKVDIWSSCCMMLHMLNGCHPW 272


>4Y93-A nrPDB
          Length = 446

 Score =  173 bits (439), Expect = 9e-44,   Method: Composition-based stats.
 Identities = 45/262 (17%), Positives = 109/262 (41%), Gaps = 28/262 (10%)

Query: 35  NQDDYQLVRKLGRGKYSEVFEAINITNNEK-VVVKILK--PVKKKKIKREIKILENLRGG 91
           +  D   +++LG G++  V         +  V +K++K   + + +   E K++ NL   
Sbjct: 186 DPKDLTFLKELGTGQFGVVKYGKWR--GQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHE 243

Query: 92  PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDY----DIRFYMYEILKALDYC 147
             ++ L  +      R   ++ E++ N       + +        +     ++ +A++Y 
Sbjct: 244 K-LVQLYGVCTKQ--RPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYL 300

Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLV 204
            S   +HRD+   N +++ +   +++ D+G+  +     EY     S++   +  PE+L+
Sbjct: 301 ESKQFLHRDLAARNCLVN-DQGVVKVSDFGMTRYVLDD-EYTSSTGSKFPVKWASPEVLM 358

Query: 205 DYQMYDYSLDMWSLGCMLASMIF-RKEPF--FHGHDNYDQLVRIAKV----LGTEDLYDY 257
            Y  +    D+W+ G ++  +    K P+  F   +  + + +  ++    L +E +Y  
Sbjct: 359 -YSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLPRPHLASERVYAI 417

Query: 258 IDKYNIE---LDPRFNDILGRH 276
           +     E     P F  +L   
Sbjct: 418 MYSCWHEKADERPTFKILLSNI 439


>6B2Q-A nrPDB
          Length = 317

 Score =  173 bits (439), Expect = 1e-43,   Method: Composition-based stats.
 Identities = 51/209 (24%), Positives = 97/209 (46%), Gaps = 17/209 (8%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK------PVKKKKIKREIKILENLRGG 91
            Y+L R +  G   +V+EA++     +V VK+LK      P   ++ + E +    L   
Sbjct: 33  RYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAML-NH 91

Query: 92  PNIITLADIVKDPV---SRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALD 145
           P I ++ D  +  +    RT  LV E VN      + +    L+       + +  +AL 
Sbjct: 92  PGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQ 151

Query: 146 YCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH--PGQEYNVRVASRYFKGPELL 203
             H+ G++HRDVKP N++I     ++++ D+G+A+     P  +  + + +  +  PE  
Sbjct: 152 IAHAAGLVHRDVKPGNILIT-PTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQA 210

Query: 204 VDYQMYDYSLDMWSLGCMLASMIFRKEPF 232
           + +     + D++SLG +    +  K PF
Sbjct: 211 LGHDA-SPASDVYSLGVVGYEAVSGKRPF 238


>4X3F-A nrPDB
          Length = 337

 Score =  173 bits (439), Expect = 1e-43,   Method: Composition-based stats.
 Identities = 51/209 (24%), Positives = 97/209 (46%), Gaps = 17/209 (8%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK------PVKKKKIKREIKILENLRGG 91
            Y+L R +  G   +V+EA++     +V VK+LK      P   ++ + E +    L   
Sbjct: 13  RYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAML-NH 71

Query: 92  PNIITLADIVKDPV---SRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALD 145
           P I ++ D  +  +    RT  LV E VN      + +    L+       + +  +AL 
Sbjct: 72  PGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQ 131

Query: 146 YCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH--PGQEYNVRVASRYFKGPELL 203
             H+ G++HRDVKP N++I     ++++ D+G+A+     P  +  + + +  +  PE  
Sbjct: 132 IAHAAGLVHRDVKPGNILIT-PTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQA 190

Query: 204 VDYQMYDYSLDMWSLGCMLASMIFRKEPF 232
           + +     + D++SLG +    +  K PF
Sbjct: 191 LGHDA-SPASDVYSLGVVGYEAVSGKRPF 218


>4OW8-A nrPDB
          Length = 283

 Score =  173 bits (439), Expect = 1e-43,   Method: Composition-based stats.
 Identities = 51/209 (24%), Positives = 97/209 (46%), Gaps = 17/209 (8%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK------PVKKKKIKREIKILENLRGG 91
            Y+L R +  G   +V+EA++     +V VK+LK      P   ++ + E +    L   
Sbjct: 12  RYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAML-NH 70

Query: 92  PNIITLADIVKDPV---SRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALD 145
           P I ++ D  +  +    RT  LV E VN      + +    L+       + +  +AL 
Sbjct: 71  PGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQ 130

Query: 146 YCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH--PGQEYNVRVASRYFKGPELL 203
             H+ G++HRDVKP N++I     ++++ D+G+A+     P  +  + + +  +  PE  
Sbjct: 131 IAHAAGLVHRDVKPGNILIT-PTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQA 189

Query: 204 VDYQMYDYSLDMWSLGCMLASMIFRKEPF 232
           + +     + D++SLG +    +  K PF
Sbjct: 190 LGHDA-SPASDVYSLGVVGYEAVSGKRPF 217


>3ZBF-A nrPDB
          Length = 322

 Score =  173 bits (438), Expect = 1e-43,   Method: Composition-based stats.
 Identities = 54/288 (18%), Positives = 103/288 (35%), Gaps = 38/288 (13%)

Query: 23  YWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAI-----NITNNE-KVVVKILKP---- 72
           Y+      +    ++   L   LG G + EV+E        + + E KV VK LK     
Sbjct: 19  YFQGSIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTD 78

Query: 73  VKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYD 132
            +K +  +E  ++      PNI+    +    ++    ++ E +   D     +      
Sbjct: 79  QEKIEFLKEAHLMSKF-NHPNILKQLGVC--LLNEPQYIILELMEGGDLLTYLRK--ARM 133

Query: 133 IRFY------------MYEILKALDYCHSMGIMHRDVKPHNVMIDHEH----RKLRLIDW 176
             FY              +I K   Y   M  +HRD+   N ++  +     R +++ D+
Sbjct: 134 ATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDF 193

Query: 177 GLAEFYHPGQEYNVRV---ASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFF 233
           GLA   +    Y  R        +  PE L+D  ++    D+WS G ++  ++      +
Sbjct: 194 GLARDIYKNDYYRKRGEGLLPVRWMAPESLMD-GIFTTQSDVWSFGILIWEILTLGHQPY 252

Query: 234 HGHDNYDQLVRIA---KVLGTEDLYDYIDKYNIELDPRFNDILGRHSR 278
             H N D L  +    ++    +  D +     +   +  D      R
Sbjct: 253 PAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHR 300


>3LZB-A nrPDB
          Length = 327

 Score =  173 bits (438), Expect = 1e-43,   Method: Composition-based stats.
 Identities = 50/278 (17%), Positives = 121/278 (43%), Gaps = 31/278 (11%)

Query: 26  YESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKV----VVKILK----PVKKKK 77
               ++    + +++ ++ LG G +  V++ + I   EKV     +K L+    P   K+
Sbjct: 4   PNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKE 63

Query: 78  IKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----LTDYDI 133
           I  E  ++ ++   P++  L  I    ++ T  L+ + +         +     +    +
Sbjct: 64  ILDEAYVMASVDN-PHVCRLLGIC---LTSTVQLITQLMPFGCLLDYVREHKDNIGSQYL 119

Query: 134 RFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFY-HPGQEYNVRV 192
             +  +I K ++Y     ++HRD+   NV++    + +++ D+GLA+      +EY+   
Sbjct: 120 LNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTP-QHVKITDFGLAKLLGAEEKEYHAEG 178

Query: 193 ASRY--FKGPELLVDYQMYDYSLDMWSLGCMLAS-MIFRKEPFF--HGHDNYDQLVRIAK 247
                 +   E ++ +++Y +  D+WS G  +   M F  +P+      +    L +  +
Sbjct: 179 GKVPIKWMALESIL-HRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGER 237

Query: 248 V----LGTEDLYDYIDKYNI---ELDPRFNDILGRHSR 278
           +    + T D+Y  + K  +   +  P+F +++   S+
Sbjct: 238 LPQPPICTIDVYMIMRKCWMIDADSRPKFRELIIEFSK 275


>2OZO-A nrPDB
          Length = 613

 Score =  172 bits (435), Expect = 3e-43,   Method: Composition-based stats.
 Identities = 51/313 (16%), Positives = 121/313 (38%), Gaps = 41/313 (13%)

Query: 4   PVPSRARVYTDVNTHRPREYWDYESHVVE---------WGNQDDYQLVR-KLGRGKYSEV 53
           P P+R     D     P +   +ES   +         +  +D+  +   +LG G +  V
Sbjct: 294 PEPARITS-PDKPRPMPMDTSVFESPFSDPEELKDKKLFLKRDNLLIADIELGCGNFGSV 352

Query: 54  FEAINITNNEK--VVVKILK----PVKKKKIKREIKILENLRGGPNIITLADIVKDPVSR 107
            + +     ++  V +K+LK        +++ RE +I+  L   P I+ L  + +   + 
Sbjct: 353 RQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDN-PYIVRLIGVCQ---AE 408

Query: 108 TPALVFEHVNNTDFKQLY----QTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVM 163
              LV E        +      + +   ++   ++++   + Y      +HR++   NV+
Sbjct: 409 ALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRNLAARNVL 468

Query: 164 IDHEHRKLRLIDWGLAEFY-HPGQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLG 219
           + + H   ++ D+GL++        Y  R A ++   +  PE + +++ +    D+WS G
Sbjct: 469 LVNRHYA-KISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI-NFRKFSSRSDVWSYG 526

Query: 220 CMLAS-MIFRKEPF--FHGHDNYDQLVRIAKVLGTEDLYDYIDK-------YNIELDPRF 269
             +   + + ++P+    G +    + +  ++    +    +         Y  E  P F
Sbjct: 527 VTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDF 586

Query: 270 NDILGRHSRKRWE 282
             +  R     + 
Sbjct: 587 LTVEQRMRACYYS 599


>2BUJ-A nrPDB
          Length = 317

 Score =  172 bits (435), Expect = 3e-43,   Method: Composition-based stats.
 Identities = 65/332 (19%), Positives = 127/332 (38%), Gaps = 68/332 (20%)

Query: 21  REYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL---KPVKKKK 77
           RE   ++ H+V   N+  Y  ++KLG G +S V     + +     +K +   +   +++
Sbjct: 14  RENLYFQGHMVIIDNK-HYLFIQKLGEGGFSYVDLVEGLHDGHFYALKRILCHEQQDREE 72

Query: 78  IKREIKILENLRGGPNIITLADIV--KDPVSRTPALVFEHVNNTDFKQLYQTL------- 128
            +RE   +  L   PNI+ L      +        L+             + L       
Sbjct: 73  AQREAD-MHRLFNHPNILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFL 131

Query: 129 TDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGL---------- 178
           T+  I + +  I + L+  H+ G  HRD+KP N+++  E + + L+D G           
Sbjct: 132 TEDQILWLLLGICRGLEAIHAKGYAHRDLKPTNILLGDEGQPV-LMDLGSMNQACIHVEG 190

Query: 179 AEFYHPGQEYNVRVASRYFKGPEL--LVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGH 236
           +      Q++  +  +  ++ PEL  +  + + D   D+WSLGC+L +M+F + P+    
Sbjct: 191 SRQALTLQDWAAQRCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPYD--- 247

Query: 237 DNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPE 296
                   +    G        ++ +I   PR +  L +                     
Sbjct: 248 --------MVFQKGDSVALAVQNQLSIPQSPRHSSALWQ--------------------- 278

Query: 297 ALDFLDKLLRYDHQSR------LTAREAMEHP 322
               L+ ++  D   R      L+  EA++ P
Sbjct: 279 ---LLNSMMTVDPHQRPHIPLLLSQLEALQPP 307


>5TE0-A nrPDB
          Length = 347

 Score =  172 bits (435), Expect = 3e-43,   Method: Composition-based stats.
 Identities = 68/379 (17%), Positives = 126/379 (33%), Gaps = 83/379 (21%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL---KPVKKKKIKREIKILENLRGGP 92
           +    +   L  G ++ VF     +N  K  +K +        +  KREI+I+ +L G  
Sbjct: 18  RQQVTVDEVLAEGGFAIVFLVR-TSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHK 76

Query: 93  NIITLADIVKDPVSRTPA----LVFEHVNNT----DFKQLYQT-LTDYDIRFYMYEILKA 143
           NI+   D   + VS        ++ +            Q  QT  T+ ++     +  +A
Sbjct: 77  NIVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEA 136

Query: 144 LDYCHSMG--IMHRDVKPHNVMIDHEHRKLRLIDWGLA--EFYHPGQEYNVRV------- 192
           +   H     I+HRD+K  N+++ H+     L D+G A  +F +P  E    V       
Sbjct: 137 VARLHQCKTPIIHRDLKVENILL-HDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKY 195

Query: 193 ASRYFKGPEL--LVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLG 250
            +  ++ PE+  L   ++     D+W+LGC+L  + +   PF                 G
Sbjct: 196 TTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPF-----------------G 238

Query: 251 TEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQ 310
              +      + I  + R++  +                           +  +L  D  
Sbjct: 239 ESQVAICDGNFTIPDNSRYSQDMH------------------------CLIRYMLEPDPD 274

Query: 311 SRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLGPLAGS 370
            R    +     YF           S  +     P+ +       + +P P      A  
Sbjct: 275 KRPDIYQV---SYF-----------SFKLLKKECPIPNVQNSPIPAKLPEPVKASEAAAK 320

Query: 371 PVIAAANPLGMPVPAAAGA 389
                A  L  P+P    +
Sbjct: 321 KTQPKA-RLTDPIPTTETS 338


>5AMN-A nrPDB
          Length = 299

 Score =  172 bits (435), Expect = 3e-43,   Method: Composition-based stats.
 Identities = 55/298 (18%), Positives = 120/298 (40%), Gaps = 47/298 (15%)

Query: 36  QDDYQLVRKLGRGKYSEVFEA-----INITNNEKVVVKILK----PVKKKKIKREIKILE 86
           + +  L + LG G++ +V +A             V VK+LK    P + + +  E  +L+
Sbjct: 22  RKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLK 81

Query: 87  NLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ-------------TLTDYDI 133
            +   P++I L             L+ E+      +   +              LT  D+
Sbjct: 82  QV-NHPHVIKLYGACSQ--DGPLLLIVEYAKYGSLRGFLRESRKVGPGYPDERALTMGDL 138

Query: 134 RFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVA 193
             + ++I + + Y   M ++HRD+   N+++  E RK+++ D+GL+   +    Y  R  
Sbjct: 139 ISFAWQISQGMQYLAEMKLVHRDLAARNILV-AEGRKMKISDFGLSRDVYEEDSYVKRSQ 197

Query: 194 SRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLG 250
            R    +   E L D+ +Y    D+WS G +L  ++      + G             + 
Sbjct: 198 GRIPVKWMAIESLFDH-IYTTQSDVWSFGVLLWEIVTLGGNPYPG-------------IP 243

Query: 251 TEDLYDYIDKYNIELDPR-FNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRY 307
            E L++ +   +    P   ++ + R   + W++    + + + +  + D  +K++  
Sbjct: 244 PERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQ--EPDKRPVFADISKDL-EKMMVK 298


>5HVK-A nrPDB
          Length = 315

 Score =  171 bits (433), Expect = 5e-43,   Method: Composition-based stats.
 Identities = 47/313 (15%), Positives = 113/313 (36%), Gaps = 64/313 (20%)

Query: 42  VRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK---IKREIKILENLRGGPNIITLA 98
              LG+G + +  +  +    E +V+K L    ++      +E+K++  L   PN++   
Sbjct: 19  GEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEH-PNVLKFI 77

Query: 99  DIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDY----DIRFYMYEILKALDYCHSMGIMH 154
            ++     +    + E++     + + +++           +  +I   + Y HSM I+H
Sbjct: 78  GVL--YKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIH 135

Query: 155 RDVKPHNVMIDHEHRKLRLIDWGLAEFYHPG---------------QEYNVRVASRYFKG 199
           R++  HN ++  E++ + + D+GLA                     ++    V + Y+  
Sbjct: 136 RNLNSHNCLV-RENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMA 194

Query: 200 PELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYID 259
           PE++ + + YD  +D++S G +L  +                   I +V    D      
Sbjct: 195 PEMI-NGRSYDEKVDVFSFGIVLCEI-------------------IGRVNADPDYLPRTM 234

Query: 260 KYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAM 319
            + + +    +     +    +                     +    D + R +  + +
Sbjct: 235 DFGLNVRGFLDRYCPPNCPPSFFPITV----------------RCCDLDPEKRPSFVK-L 277

Query: 320 EHPYFYTVVKDQA 332
           EH +  T+    A
Sbjct: 278 EH-WLETLRMHLA 289


>1K9A-A nrPDB
          Length = 450

 Score =  170 bits (431), Expect = 9e-43,   Method: Composition-based stats.
 Identities = 51/297 (17%), Positives = 107/297 (36%), Gaps = 55/297 (18%)

Query: 35  NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK-KKIKREIKILENLRGGPN 93
           N  + +L++ +G+G++ +V          KV VK +K     +    E  ++  LR   N
Sbjct: 191 NMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQAFLAEASVMTQLRHS-N 247

Query: 94  IITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT-----LTDYDIRFYMYEILKALDYCH 148
           ++ L  ++ +       +V E++         ++     L    +  +  ++ +A++Y  
Sbjct: 248 LVQLLGVIVEEKGG-LYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE 306

Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQM 208
               +HRD+   NV++  ++   ++ D+GL +     Q+         +  PE L + + 
Sbjct: 307 GNNFVHRDLAARNVLVSEDN-VAKVSDFGLTKEASSTQDTGKL--PVKWTAPEALRE-KK 362

Query: 209 YDYSLDMWSLGCMLASMI-FRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDP 267
           +    D+WS G +L  +  F + P+                                   
Sbjct: 363 FSTKSDVWSFGILLWEIYSFGRVPY----------------------------------- 387

Query: 268 RFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT---AREAMEH 321
               I  +    R E+    +      P   D +      D  +R T    RE +EH
Sbjct: 388 --PRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEH 442


>5U6B-A nrPDB
          Length = 307

 Score =  169 bits (429), Expect = 1e-42,   Method: Composition-based stats.
 Identities = 53/329 (16%), Positives = 110/329 (33%), Gaps = 77/329 (23%)

Query: 41  LVRKLGRGKYSEVFEAINITNN--EKVVVKILK-----PVKKKKIKREIKILENLRGGPN 93
           L + LG G++  V E     ++   KV VK +K       + +    E   ++     PN
Sbjct: 27  LGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEF-DHPN 85

Query: 94  IITLADIV----KDPVSRTPALVFEHVNNTDFKQLYQT---------LTDYDIRFYMYEI 140
           ++ L  +     +      P ++   + + D                L    +  +M +I
Sbjct: 86  VMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADI 145

Query: 141 LKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY---F 197
              ++Y  +   +HRD+   N M++ E+  + + D+GL++  + G  Y     ++    +
Sbjct: 146 ASGMEYLSTKRFIHRDLAARNCMLN-ENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKW 204

Query: 198 KGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDN---YDQLVRIAKVLGTEDL 254
              E L D ++Y    D+WS G  +  +  R +  + G +N   YD L +  ++    D 
Sbjct: 205 IAIESLAD-RVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADC 263

Query: 255 YDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT 314
            D +                                          + +    + Q R +
Sbjct: 264 LDGLYA---------------------------------------LMSRCWELNPQDRPS 284

Query: 315 AREAMEHPYFYTVVKDQARMGSSSMPGGS 343
                    F  + +D      +  P   
Sbjct: 285 ---------FTELREDLENTLKALPPAQE 304


>3PLS-A nrPDB
          Length = 298

 Score =  169 bits (429), Expect = 2e-42,   Method: Composition-based stats.
 Identities = 54/276 (19%), Positives = 110/276 (39%), Gaps = 29/276 (10%)

Query: 43  RKLGRGKYSEVFEAINITNNE---KVVVKILKPV----KKKKIKREIKILENLRGGPNII 95
           R +G+G +  V+    I   +   +  +K L  +    + +   RE  ++  L   PN++
Sbjct: 27  RVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGL-NHPNVL 85

Query: 96  TLADIVKDPVSRTPALVFEHVNNTDFKQLYQTL----TDYDIRFYMYEILKALDYCHSMG 151
            L  I+  P      L   ++ + D  Q  ++     T  D+  +  ++ + ++Y     
Sbjct: 86  ALIGIMLPPEGLPHVL-LPYMCHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLAEQK 144

Query: 152 IMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVR-----VASRYFKGPELLVDY 206
            +HRD+   N M+D E   +++ D+GLA      + Y+V+          +   E L  Y
Sbjct: 145 FVHRDLAARNCMLD-ESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWTALESLQTY 203

Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQ---LVRIAKVLGTEDLYDYIDKYNI 263
           + +    D+WS G +L  ++ R  P +   D +D    L +  ++   E   D + +   
Sbjct: 204 R-FTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSLYQVMQ 262

Query: 264 ELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALD 299
           +       +          R +  E + +VS    D
Sbjct: 263 QCWEADPAVRPTF------RVLVGEVEQIVSALLGD 292


>4YFF-A nrPDB
          Length = 311

 Score =  169 bits (429), Expect = 2e-42,   Method: Composition-based stats.
 Identities = 43/266 (16%), Positives = 92/266 (34%), Gaps = 29/266 (10%)

Query: 40  QLVRKLGRGKYSEVFEAINITNNEKVVVKI------LKPVKKKKIKREIKILENLRGGPN 93
           +    +G G + +V++      N+ V +K                 RE+ IL  L   P 
Sbjct: 45  EFHEIIGSGSFGKVYKGRCR--NKIVAIKRYRANTYCSKSDVDMFCREVSILCQL-NHPC 101

Query: 94  IITLADIVKDPVSRTPALVFEHVNNTDFKQLY----QTLTDYDIRFYMYEILKALDYCH- 148
           +I       +  S+  A+V ++++      L     + L          ++ K ++Y H 
Sbjct: 102 VIQFVGACLNDPSQ-FAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLHN 160

Query: 149 -SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH--PGQEYNVRVASRYFKGPELLVD 205
            +  I+HRD+  HN+++  +   + + D+G + F           +  +  +  PE+   
Sbjct: 161 LTQPIIHRDLNSHNILLYEDGHAV-VADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQ 219

Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYN--- 262
              Y    D++S    L  ++  + PF H              +     Y      +   
Sbjct: 220 CTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPISSLL 279

Query: 263 -------IELDPRFNDILGRHSRKRW 281
                   E  P F++++ +      
Sbjct: 280 IRGWNACPEGRPEFSEVVMKLEECLC 305


>1BYG-A nrPDB
          Length = 278

 Score =  167 bits (424), Expect = 5e-42,   Method: Composition-based stats.
 Identities = 43/257 (16%), Positives = 101/257 (39%), Gaps = 24/257 (9%)

Query: 35  NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK-KKIKREIKILENLRGGPN 93
           N  + +L++ +G+G++ +V          KV VK +K     +    E  ++  LR   N
Sbjct: 19  NMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQAFLAEASVMTQLRHS-N 75

Query: 94  IITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT-----LTDYDIRFYMYEILKALDYCH 148
           ++ L  ++ +       +V E++         ++     L    +  +  ++ +A++Y  
Sbjct: 76  LVQLLGVIVEEKGG-LYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE 134

Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQM 208
               +HRD+   NV++  ++   ++ D+GL +     Q+         +  PE L + + 
Sbjct: 135 GNNFVHRDLAARNVLVSEDN-VAKVSDFGLTKEASSTQDTGKL--PVKWTAPEALRE-KK 190

Query: 209 YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVL-------GTEDLYDYIDKY 261
           +    D+WS G +L  +       +      D + R+ K             +Y+ +   
Sbjct: 191 FSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNC 250

Query: 262 ---NIELDPRFNDILGR 275
              +  + P F  +  +
Sbjct: 251 WHLDAAMRPSFLQLREQ 267


>5VD3-A nrPDB
          Length = 311

 Score =  167 bits (424), Expect = 5e-42,   Method: Composition-based stats.
 Identities = 63/296 (21%), Positives = 107/296 (36%), Gaps = 54/296 (18%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKI-LKP----VKKKKIKREIKILENLRG 90
           Q  +Q + +LG G Y EVF+  +  +     VK  + P      + +   E+   E +  
Sbjct: 56  QQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQ 115

Query: 91  GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ----TLTDYDIRFYMYEILKALDY 146
            P  + L    ++       L  E       +Q  +    +L +  +  Y+ + L AL +
Sbjct: 116 HPCCVRLEQAWEE--GGILYLQTELC-GPSLQQHCEAWGASLPEAQVWGYLRDTLLALAH 172

Query: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDY 206
            HS G++H DVKP N+ +    R  +L D+GL           V+     +  PELL   
Sbjct: 173 LHSQGLVHLDVKPANIFLGPRGR-CKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGS 231

Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 266
             Y  + D++SLG  +  +    E   HG + + QL +                      
Sbjct: 232 --YGTAADVFSLGLTILEVACNME-LPHGGEGWQQLRQG--------------------- 267

Query: 267 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHP 322
                            ++  E    +S E    L  +L  D + R TA   +  P
Sbjct: 268 -----------------YLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALP 306


>3QUP-A nrPDB
          Length = 323

 Score =  167 bits (424), Expect = 6e-42,   Method: Composition-based stats.
 Identities = 55/303 (18%), Positives = 110/303 (36%), Gaps = 63/303 (20%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNE---KVVVKILK-----PVKKKKIKREIKILEN 87
           +  + L R LG+G++  V EA     +    KV VK+LK         ++  RE   ++ 
Sbjct: 22  EQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKE 81

Query: 88  LRGGPNIITLADIVKDPVSRT----PALVFEHVNNTDFKQLYQT---------LTDYDIR 134
               P++  L  +     ++     P ++   + + D                L    + 
Sbjct: 82  F-DHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLV 140

Query: 135 FYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVAS 194
            +M +I   ++Y  S   +HRD+   N M+  E   + + D+GL+   + G  Y    AS
Sbjct: 141 RFMVDIACGMEYLSSRNFIHRDLAARNCML-AEDMTVCVADFGLSRKIYSGDYYRQGCAS 199

Query: 195 RY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGT 251
           +    +   E L D  +Y    D+W+ G  +  ++ R +  + G +N +           
Sbjct: 200 KLPVKWLALESLAD-NLYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEI---------- 248

Query: 252 EDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQS 311
                            +N ++G +  K+    +          E  D + +    D + 
Sbjct: 249 -----------------YNYLIGGNRLKQPPECM---------EEVYDLMYQCWSADPKQ 282

Query: 312 RLT 314
           R +
Sbjct: 283 RPS 285


>6FER-A nrPDB
          Length = 309

 Score =  167 bits (424), Expect = 6e-42,   Method: Composition-based stats.
 Identities = 57/305 (18%), Positives = 118/305 (38%), Gaps = 53/305 (17%)

Query: 39  YQLVRKLGRGKYSEVFEA--------------INITNNE--KVVVKILK----PVKKKKI 78
                KLG G++ EV                 ++++ N+   V VK+L+       +   
Sbjct: 11  LTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDF 70

Query: 79  KREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY------------- 125
            +EIKI+  L+  PNII L  +          ++ E++ N D  Q               
Sbjct: 71  LKEIKIMSRLKD-PNIIHLLAVC--ITDDPLCMITEYMENGDLNQFLSRHEPPNSSSSDV 127

Query: 126 QTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPG 185
           +T++  +++F   +I   + Y  S+  +HRD+   N ++  ++  +++ D+G++   + G
Sbjct: 128 RTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVG-KNYTIKIADFGMSRNLYSG 186

Query: 186 QEYNVR---VASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQL 242
             Y ++   V    +   E ++    +  + D+W+ G  L          F     Y QL
Sbjct: 187 DYYRIQGRAVLPIRWMSWESIL-LGKFTTASDVWAFGVTLWETFT-----FCQEQPYSQL 240

Query: 243 VRIAKVLGTEDLYDYIDKYNIELDPR-FNDILGRHSRKRWERFVHSENQHLVSPEALDFL 301
                +  T + +    +      P    D + +     W R    + ++  S + +  L
Sbjct: 241 SDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRR----DTKNRPSFQEIHLL 296

Query: 302 DKLLR 306
             LL+
Sbjct: 297 --LLQ 299


>4TPT-A nrPDB
          Length = 303

 Score =  167 bits (422), Expect = 1e-41,   Method: Composition-based stats.
 Identities = 42/212 (19%), Positives = 92/212 (43%), Gaps = 32/212 (15%)

Query: 42  VRKLGRGKYSEVFEAINITNNEKVVVKIL---KPVKKKKIKREIKILENLRGGPNIITLA 98
              LG+G + +  +  +    + +V+K L       +K    E+K++ +L   PN++   
Sbjct: 5   GEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSL-DHPNVLKFI 63

Query: 99  DIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDY---DIRFYMYEILKALDYCHSMGIMHR 155
            ++     +   L+ E++     K   +++  +       +   I   + Y HSM I+HR
Sbjct: 64  GVL--YKDKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMAYLHSMCIIHR 121

Query: 156 DVKPHNVMIDHEHRKLRLIDWGLAEFY---------------------HPGQEYNVRVAS 194
           D+  HN +I  + + + + D+GL+                        +  ++    V +
Sbjct: 122 DLNSHNCLIKLD-KTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGN 180

Query: 195 RYFKGPELLVDYQMYDYSLDMWSLGCMLASMI 226
            Y+  PE+L + + YD ++D++S G +L  +I
Sbjct: 181 PYWMAPEML-NGKSYDETVDIFSFGIVLCEII 211


>5FM2-A nrPDB
          Length = 355

 Score =  166 bits (420), Expect = 2e-41,   Method: Composition-based stats.
 Identities = 55/312 (17%), Positives = 120/312 (38%), Gaps = 61/312 (19%)

Query: 36  QDDYQLVRKLGRGKYSEVFEA-----INITNNEKVVVKILK----PVKKKKIKREIKILE 86
           + +  L + LG G++ +V +A             V VK+LK    P + + +  E  +L+
Sbjct: 63  RKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLK 122

Query: 87  NLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ-------------------- 126
            +   P++I L             L+ E+      +   +                    
Sbjct: 123 QV-NHPHVIKLYGACSQ--DGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSS 179

Query: 127 -------TLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA 179
                   LT  D+  + ++I + + Y   M ++HRD+   N+++  E RK+++ D+GL+
Sbjct: 180 LDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILV-AEGRKMKISDFGLS 238

Query: 180 EFYHPGQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGH 236
              +    Y  R   R    +   E L D+ +Y    D+WS G +L  ++      + G 
Sbjct: 239 RDVYEEDSYVKRSQGRIPVKWMAIESLFDH-IYTTQSDVWSFGVLLWEIVTLGGNPYPG- 296

Query: 237 DNYDQLVRIAKVLGTEDLYDYIDKYNIELDPR-FNDILGRHSRKRWERFVHSENQHLVSP 295
                       +  E L++ +   +    P   ++ + R   + W++    + + + + 
Sbjct: 297 ------------IPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQ--EPDKRPVFAD 342

Query: 296 EALDFLDKLLRY 307
            + D  +K++  
Sbjct: 343 ISKDL-EKMMVK 353


>3I81-A nrPDB
          Length = 315

 Score =  165 bits (419), Expect = 2e-41,   Method: Composition-based stats.
 Identities = 51/289 (17%), Positives = 107/289 (37%), Gaps = 41/289 (14%)

Query: 32  EWG-NQDDYQLVRKLGRGKYSEVFEAINI-----TNNEKVVVKILKPV----KKKKIKRE 81
           EW   ++   + R+LG+G +  V+E +           +V +K +       ++ +   E
Sbjct: 12  EWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNE 71

Query: 82  IKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDY---------- 131
             +++      +++ L  +V     +   ++ E +   D K   ++L             
Sbjct: 72  ASVMKEFNCH-HVVRLLGVVSQ--GQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPP 128

Query: 132 ---DIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEY 188
               +     EI   + Y ++   +HRD+   N M+  E   +++ D+G+    +    Y
Sbjct: 129 SLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV-AEDFTVKIGDFGMTRDIYETDYY 187

Query: 189 NVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRI 245
                      +  PE L D  ++    D+WS G +L  +    E  + G  N   L  +
Sbjct: 188 RKGGKGLLPVRWMSPESLKD-GVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFV 246

Query: 246 AK--VLGTED--------LYDYIDKYNIELDPRFNDILGRHSRKRWERF 284
            +  +L   D        L     +YN ++ P F +I+     +    F
Sbjct: 247 MEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGF 295


>5IKW-A nrPDB
          Length = 310

 Score =  165 bits (418), Expect = 3e-41,   Method: Composition-based stats.
 Identities = 64/350 (18%), Positives = 121/350 (34%), Gaps = 81/350 (23%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKI---KREIKILENLRGGP 92
           +    L   L  G +S VF         +  +K +       +   KREI I++ L G  
Sbjct: 13  RHQVTLEESLAEGGFSTVFLVR-THGGIRCALKRMYVNNMPDLNVCKREITIMKELSGHK 71

Query: 93  NIITLADIVKDPVSRTPA---LVFEHVNNTDF-----KQLYQTLTDYDIRFYMYEILKAL 144
           NI+   D   + +S       ++ E+           K+L    T+ ++     +  +A+
Sbjct: 72  NIVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAV 131

Query: 145 DYCHSMG--IMHRDVKPHNVMIDHEHRKLRLIDWGLA--EFYHPGQEYNVRV-------A 193
              H     I+HRD+K  N++++ +     L D+G A  +F +P ++    V        
Sbjct: 132 ARLHQCKTPIIHRDLKVENILLN-DGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYT 190

Query: 194 SRYFKGPELLV--DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGT 251
           +  ++ PE++     +      D+W+LGC+L  + F   PF                 G 
Sbjct: 191 TLSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPF-----------------GE 233

Query: 252 EDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQS 311
             +      + I  + R++  +                           +  +L  D + 
Sbjct: 234 SQVAICDGNFTIPDNSRYSRNIH------------------------CLIRFMLEPDPEH 269

Query: 312 RLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTP 361
           R    +     YF           +        PVS+ N  S  S++P P
Sbjct: 270 RPDIFQV---SYF-----------AFKFAAADCPVSNINNSSIPSALPEP 305


>4HZS-A nrPDB
          Length = 341

 Score =  165 bits (417), Expect = 3e-41,   Method: Composition-based stats.
 Identities = 47/229 (20%), Positives = 87/229 (37%), Gaps = 23/229 (10%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAI-NITNNEKV--VVKILKP------VKKKKIKREIKILE 86
           + D +L+ KLG G +  V     +  + + V   VK LKP             RE+  + 
Sbjct: 11  EKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMH 70

Query: 87  NLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----LTDYDIRFYMYEILK 142
           +L    N+I L  +V  P  +   +V E           +          +  Y  ++ +
Sbjct: 71  SL-DHRNLIRLYGVVLTPPMK---MVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAE 126

Query: 143 ALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNV----RVASRYFK 198
            + Y  S   +HRD+   N+++      +++ D+GL        ++ V    R     + 
Sbjct: 127 GMGYLESKRFIHRDLAARNLLLATRDL-VKIGDFGLMRALPQNDDHYVMQEHRKVPFAWC 185

Query: 199 GPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAK 247
            PE L   + + ++ D W  G  L  M    +  + G +    L +I K
Sbjct: 186 APESL-KTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDK 233


>5U6C-A nrPDB
          Length = 315

 Score =  164 bits (416), Expect = 5e-41,   Method: Composition-based stats.
 Identities = 47/257 (18%), Positives = 103/257 (40%), Gaps = 29/257 (11%)

Query: 35  NQDDYQLVRKLGRGKYSEVFEAINIT---NNEKVVVKILK-----PVKKKKIKREIKILE 86
           +++   L + LG G++  V E         + KV VK +K       + ++   E   ++
Sbjct: 34  DRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMK 93

Query: 87  NLRGGPNIITLADIVKDPVSR---TPALVFEHVNNTDFKQLY---------QTLTDYDIR 134
           +    PN++ L  +  +  S+    P ++   +   D              + +    + 
Sbjct: 94  DFSH-PNVMRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLL 152

Query: 135 FYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVAS 194
            +M +I   ++Y  +   +HRD+   N M+  +   + + D+GL++  + G  Y     +
Sbjct: 153 KFMVDIALGMEYLSNRNFLHRDLAARNCML-RDDMTVCVADFGLSKKIYSGDYYRQGRIA 211

Query: 195 RY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHG---HDNYDQLVRIAKV 248
           +    +   E L D ++Y    D+W+ G  +  +  R    + G   H+ YD L+   ++
Sbjct: 212 KMPVKWIAIESLAD-RVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRL 270

Query: 249 LGTEDLYDYIDKYNIEL 265
              ED  D + +     
Sbjct: 271 KQPEDCLDELYEIMYSC 287


>3ZZW-A nrPDB
          Length = 289

 Score =  164 bits (414), Expect = 8e-41,   Method: Composition-based stats.
 Identities = 46/272 (16%), Positives = 104/272 (38%), Gaps = 39/272 (14%)

Query: 40  QLVRKLGRGKYSEVFEAINI-----TNNEKVVVKILKPVK----KKKIKREIKILENLRG 90
           + + +LG  ++ +V++            + V +K LK       +++ + E  +   L+ 
Sbjct: 12  RFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRARLQH 71

Query: 91  GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY-------------------QTLTDY 131
            PN++ L  +V     +  +++F + ++ D  +                       L   
Sbjct: 72  -PNVVCLLGVVT--KDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPP 128

Query: 132 DIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVR 191
           D    + +I   ++Y  S  ++H+D+   NV++ ++   +++ D GL    +    Y + 
Sbjct: 129 DFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLV-YDKLNVKISDLGLFREVYAADYYKLL 187

Query: 192 VASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAK- 247
             S     +  PE ++ Y  +    D+WS G +L  +       + G+ N D +  I   
Sbjct: 188 GNSLLPIRWMAPEAIM-YGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNR 246

Query: 248 --VLGTEDLYDYIDKYNIELDPRFNDILGRHS 277
             +   +D   ++    IE    F     R  
Sbjct: 247 QVLPCPDDCPAWVYALMIECWNEFPSRRPRFK 278


>1U54-B nrPDB
          Length = 291

 Score =  164 bits (414), Expect = 9e-41,   Method: Composition-based stats.
 Identities = 47/229 (20%), Positives = 87/229 (37%), Gaps = 23/229 (10%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAI-NITNNEKV--VVKILKP------VKKKKIKREIKILE 86
           + D +L+ KLG G +  V     +  + + V   VK LKP             RE+  + 
Sbjct: 17  EKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMH 76

Query: 87  NLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----LTDYDIRFYMYEILK 142
           +L    N+I L  +V  P  +   +V E           +          +  Y  ++ +
Sbjct: 77  SL-DHRNLIRLYGVVLTPPMK---MVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAE 132

Query: 143 ALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNV----RVASRYFK 198
            + Y  S   +HRD+   N+++      +++ D+GL        ++ V    R     + 
Sbjct: 133 GMGYLESKRFIHRDLAARNLLLATRDL-VKIGDFGLMRALPQNDDHYVMQEHRKVPFAWC 191

Query: 199 GPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAK 247
            PE L   + + ++ D W  G  L  M    +  + G +    L +I K
Sbjct: 192 APESL-KTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDK 239


>3MDY-A nrPDB
          Length = 337

 Score =  162 bits (410), Expect = 2e-40,   Method: Composition-based stats.
 Identities = 65/301 (21%), Positives = 114/301 (37%), Gaps = 46/301 (15%)

Query: 40  QLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILEN-LRGGPNIITLA 98
           Q+V+++G+G+Y EV+        EKV VK+    ++    RE +I +  L    NI+   
Sbjct: 40  QMVKQIGKGRYGEVWMGKWR--GEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFI 97

Query: 99  --DIVKDPVSRTPALVFEHVNNTDFKQLYQ--TLTDYDIRFYMYEILKALDYCH------ 148
             DI          L+ ++  N       +  TL    +    Y  +  L + H      
Sbjct: 98  AADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEIFST 157

Query: 149 --SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEY----NVRVASRYFKGPE 201
                I HRD+K  N+++  ++    + D GLA +F     E     N RV ++ +  PE
Sbjct: 158 QGKPAIAHRDLKSKNILV-KKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPE 216

Query: 202 LLVD------YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLY 255
           +L +      +Q Y    DM+S G +L  +  R                     G  + Y
Sbjct: 217 VLDESLNRNHFQSY-IMADMYSFGLILWEVARRCV-----------------SGGIVEEY 258

Query: 256 DYIDKYNIELDPRFNDILGRHS-RKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT 314
                  +  DP + D+      +K    F +  +      +    + +   ++  SRLT
Sbjct: 259 QLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLT 318

Query: 315 A 315
           A
Sbjct: 319 A 319


>5UIU-A nrPDB
          Length = 323

 Score =  160 bits (405), Expect = 9e-40,   Method: Composition-based stats.
 Identities = 42/203 (20%), Positives = 79/203 (38%), Gaps = 24/203 (11%)

Query: 44  KLGRGKYSEVFEAINITNNEKVVVKIL-------KPVKKKKIKREIKILENLRGGPNIIT 96
           K+G G +  V++     NN  V VK L           K++  +EIK++   +   N++ 
Sbjct: 54  KMGEGGFGVVYKGY--VNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQH-ENLVE 110

Query: 97  LADIVKDPVSRTPALVFEHVNNTDFKQLYQTLT-----DYDIRFYMYE-ILKALDYCHSM 150
           L     D        V  ++ N         L       + +R  + +     +++ H  
Sbjct: 111 LLGFSSDGDDLCLVYV--YMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHEN 168

Query: 151 GIMHRDVKPHNVMIDHEHRKLRLIDWGLAE---FYHPGQEYNVRVASRYFKGPELLVDYQ 207
             +HRD+K  N+++D E    ++ D+GLA     +      +  V +  +  PE L    
Sbjct: 169 HHIHRDIKSANILLD-EAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGE- 226

Query: 208 MYDYSLDMWSLGCMLASMIFRKE 230
                 D++S G +L  +I    
Sbjct: 227 -ITPKSDIYSFGVVLLEIITGLP 248


>6DC0-A nrPDB
          Length = 292

 Score =  159 bits (403), Expect = 1e-39,   Method: Composition-based stats.
 Identities = 63/284 (22%), Positives = 108/284 (38%), Gaps = 52/284 (18%)

Query: 53  VFEAINITNNEKVVVKILK-PVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPAL 111
           V  A+ I    ++  K+      + KI+  I+    L    NI     IV+  +  T A 
Sbjct: 22  VSRALCIHTGRELRCKVFPIKHYQDKIRPYIQ----LPSHSNI---TGIVEVILGETKAY 74

Query: 112 VFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEH 168
           VF   +  D     ++   L + +      +I+ A+ +CH   I+  D+K    +   E 
Sbjct: 75  VFFEKDFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEE 134

Query: 169 R-KLRLIDWGLAEFYH-PGQEYNVRVASRYFKGPELLVDYQMY-DYSLDMWSLGCMLASM 225
           R +LRL                + +     +  PE+L     Y   + D+WSLG ML ++
Sbjct: 135 RTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTL 194

Query: 226 IFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFV 285
           +  + PF                                     +D     S+ R  +F 
Sbjct: 195 LVGRYPFHD-----------------------------------SDPSALFSKIRRGQFC 219

Query: 286 HSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 329
             E+   +SP+A   +  LLR +   RLTA E + HP+F +V++
Sbjct: 220 IPEH---ISPKARCLIRSLLRREPSERLTAPEILLHPWFESVLE 260


>5CEK-A nrPDB
          Length = 263

 Score =  159 bits (403), Expect = 2e-39,   Method: Composition-based stats.
 Identities = 63/284 (22%), Positives = 108/284 (38%), Gaps = 52/284 (18%)

Query: 53  VFEAINITNNEKVVVKILK-PVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPAL 111
           V  A+ I    ++  K+      + KI+  I+    L    NI     IV+  +  T A 
Sbjct: 25  VSRALCIHTGRELRCKVFPIKHYQDKIRPYIQ----LPSHSNI---TGIVEVILGETKAY 77

Query: 112 VFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEH 168
           VF   +  D     ++   L + +      +I+ A+ +CH   I+  D+K    +   E 
Sbjct: 78  VFFEKDFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEE 137

Query: 169 R-KLRLIDWGLAEFYH-PGQEYNVRVASRYFKGPELLVDYQMY-DYSLDMWSLGCMLASM 225
           R +LRL                + +     +  PE+L     Y   + D+WSLG ML ++
Sbjct: 138 RTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTL 197

Query: 226 IFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFV 285
           +  + PF                                     +D     S+ R  +F 
Sbjct: 198 LVGRYPFHD-----------------------------------SDPSALFSKIRRGQFC 222

Query: 286 HSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 329
             E+   +SP+A   +  LLR +   RLTA E + HP+F +V++
Sbjct: 223 IPEH---ISPKARCLIRSLLRREPSERLTAPEILLHPWFESVLE 263


>4NEU-A nrPDB
          Length = 333

 Score =  157 bits (398), Expect = 6e-39,   Method: Composition-based stats.
 Identities = 55/304 (18%), Positives = 111/304 (36%), Gaps = 43/304 (14%)

Query: 28  SHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP-----VKKKKIKREI 82
           S  V      D+    +L  G + +V    + T    + +K +          + +  E 
Sbjct: 15  SLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMI-MKTVYKGPNCIEHNEALLEEA 73

Query: 83  KILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ---TLTDYDIRFYMYE 139
           K++  LR    ++ L  ++ +    +  LV E++   +   + +   +         + E
Sbjct: 74  KMMNRLRHSR-VVKLLGVIIEEGKYS--LVMEYMEKGNLMHVLKAEMSTPLSVKGRIILE 130

Query: 140 ILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA--------------EFYHPG 185
           I++ + Y H  G++H+D+KP N+++D++   +++ D GLA              E     
Sbjct: 131 IIEGMCYLHGKGVIHKDLKPENILVDND-FHIKIADLGLASFKMWSKLNNEEHNELREVD 189

Query: 186 QEYNVRVASRYFKGPELLVDYQ-MYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVR 244
                   + Y+  PE L D         D++S   +L ++   KEP+ +      QL+ 
Sbjct: 190 GTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICE-QQLIM 248

Query: 245 IAKVLGTEDLYDY--------------IDKYNIELDPRFNDILGRHSRKRWERFVHSENQ 290
             K     D+ D                 + N E  P F  I  +       +   S  +
Sbjct: 249 CIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEE 308

Query: 291 HLVS 294
            + S
Sbjct: 309 DVKS 312


>3Q4U-A nrPDB
          Length = 301

 Score =  157 bits (397), Expect = 7e-39,   Method: Composition-based stats.
 Identities = 59/312 (18%), Positives = 105/312 (33%), Gaps = 64/312 (20%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLR-GGPNIIT 96
           D  L+  +G+G+Y EV+        E V VKI     +K   RE ++   +     NI+ 
Sbjct: 9   DITLLECVGKGRYGEVWRGSWQ--GENVAVKIFSSRDEKSWFRETELYNTVMLRHENILG 66

Query: 97  LA--DIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDI--RFYMYEILKALDYCH---- 148
               D+     S    L+  +          Q  T   +     +  I   L + H    
Sbjct: 67  FIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIF 126

Query: 149 ----SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE-----YNVRVASRYFKG 199
                  I HRD+K  N+++  ++ +  + D GLA  +           N RV ++ +  
Sbjct: 127 GTQGKPAIAHRDLKSKNILV-KKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMA 185

Query: 200 PELLVD------YQMYDYSLDMWSLGCMLASMIFR----------KEPFFHGHDNYDQLV 243
           PE+L +      +  Y   +D+W+ G +L  +  R          K PF+    N     
Sbjct: 186 PEVLDETIQVDCFDSY-KRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFE 244

Query: 244 RIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDK 303
            + KV+  +     I                                  ++  A   + +
Sbjct: 245 DMRKVVCVDQQRPNIPNRWFS-------------------------DPTLTSLAK-LMKE 278

Query: 304 LLRYDHQSRLTA 315
               +  +RLTA
Sbjct: 279 CWYQNPSARLTA 290


>4M66-A nrPDB
          Length = 325

 Score =  156 bits (394), Expect = 2e-38,   Method: Composition-based stats.
 Identities = 56/225 (24%), Positives = 102/225 (45%), Gaps = 21/225 (9%)

Query: 22  EYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKRE 81
           + W   +  V   ++++ + +  +G+G +  VF A + T N  V VKI+     KKI  E
Sbjct: 5   KLWPTGASAVPLVSREELKKLEFVGKGGFGVVFRAHHRTWNHDVAVKIVNS---KKISWE 61

Query: 82  IKILENLRGGPNIITLADIVKDPVSRTP---ALVFEHVNNTDFKQLYQTLTDYD---IRF 135
           +K + NLR   N++ L  + +D         ALV   + N     L Q         +  
Sbjct: 62  VKAMVNLRN-ENVLLLLGVTEDLQWDFVSGQALVTRFMENGSLAGLLQPEAPRPWPLLCR 120

Query: 136 YMYEILKALDYCHSMG--IMHRDVKPHNVMIDHEHRKLRLIDWGLAEF-------YHPGQ 186
            + E++  + Y HS+   ++HRD+KP N+++D E    +L D+GL+ F          G 
Sbjct: 121 LLQEVVLGMCYLHSLDPPLLHRDLKPSNILLDPELHA-KLADFGLSTFQGGSQSGSGSGS 179

Query: 187 EYNVRVASRYFKGPELLVDYQ-MYDYSLDMWSLGCMLASMIFRKE 230
                  +  +  PELL         + D++S G ++ +++  +E
Sbjct: 180 GSRDSGGTLAYLDPELLFKVNLKASKASDVYSFGILVWAVLAGRE 224


>5L2Q-C nrPDB
          Length = 320

 Score =  155 bits (393), Expect = 2e-38,   Method: Composition-based stats.
 Identities = 49/311 (15%), Positives = 101/311 (32%), Gaps = 80/311 (25%)

Query: 54  FEAINITNNEKVVVKILKPVKKKK--------------IKREIKILENLRGGPNIITLAD 99
             A     ++   +KIL   ++                +  E  +L  L     ++    
Sbjct: 33  CLARKDGTDDFYQLKILTLEERGDQGIESQEERQGKMLLHTEYSLLSLLHTQDGVVHHHG 92

Query: 100 IVKD----------------PVSRTPALVFEHVNNTDFKQL-------------YQTLTD 130
           + +D                 + +   LV + +   DF                 + L++
Sbjct: 93  LFQDRTCEIVEDTESSRMVKKMKKRICLVLDCLCAHDFSDKTADLINLQHYVIKEKRLSE 152

Query: 131 YDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE-FYHPGQEYN 189
            +     Y++++ ++  H   I+HRD+K  N++++    ++ + ++ L +     G    
Sbjct: 153 RETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEGDLLK 212

Query: 190 VRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVL 249
            +  S  +  P++L          DMW+LG +L +M++ + PF+                
Sbjct: 213 DQRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPFYD--------------- 257

Query: 250 GTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDH 309
                                 I     RK             VS   +  + KLL  D 
Sbjct: 258 ---------------------SIPQELFRKIKAAEYTIPEDGRVSENTVCLIRKLLVLDP 296

Query: 310 QSRLTAREAME 320
           Q RL A + +E
Sbjct: 297 QQRLAAADVLE 307


>5TOS-A nrPDB
          Length = 395

 Score =  155 bits (393), Expect = 3e-38,   Method: Composition-based stats.
 Identities = 63/357 (17%), Positives = 120/357 (33%), Gaps = 60/357 (16%)

Query: 38  DYQLVRKLGRGKYSEVFEA---------INITNNEKVVVKILKP---VKKKKIKREIKIL 85
           +++    +G G +  VF+                  + VK L        ++   EI  L
Sbjct: 66  NFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYL 125

Query: 86  ENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY-------QTLTDYDIRFYMY 138
             L   PN++ L     +   R   LV+E +     +          + L  +       
Sbjct: 126 GQLSH-PNLVKLIGYCLEDEHR--LLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVAL 182

Query: 139 EILKALDYCHS--MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF--YHPGQEYNVRV-A 193
           +  K L + HS  + +++RD+K  N+++D ++   +L D+GLA           + RV  
Sbjct: 183 DAAKGLAFLHSDPVKVIYRDIKASNILLDADYNA-KLSDFGLARDGPMGDLSYVSTRVMG 241

Query: 194 SRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTED 253
           +  +  PE +      +   D++S G +L  ++  K    H     +           E+
Sbjct: 242 TYGYAAPEYM-SSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKE-----------EN 289

Query: 254 LYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRL 313
           L D+   Y          +  R   +             V         + L ++ +SR 
Sbjct: 290 LVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAV---------QCLSFEPKSRP 340

Query: 314 TARE---AMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVP--TPSPLG 365
           T  +   A++       ++D     S + P   T        +  SS    T  P G
Sbjct: 341 TMDQVVRALQ------QLQDNLGKPSQTNPVKDTKKLGFKTGTTKSSEKRFTQKPFG 391


>4LQP-A nrPDB
          Length = 508

 Score =  155 bits (392), Expect = 3e-38,   Method: Composition-based stats.
 Identities = 44/198 (22%), Positives = 87/198 (43%), Gaps = 14/198 (7%)

Query: 1   MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINIT 60
           ++    S  R    +++   +E   +        + +D+  V+ +G+G + EV       
Sbjct: 67  LTSHNWSEERKSRQLSSLGKKE-SQFLRLRRTRLSLEDFHTVKVIGKGAFGEVRLVQKKD 125

Query: 61  NNEKVVVKIL------KPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFE 114
             +   +K L      K  +   +K E  +L      P +++L    +D  ++   L+ E
Sbjct: 126 TGKIYAMKTLLKSEMYKKDQLAHVKAERDVLAG-SDSPWVVSLYYSFQD--AQYLYLIME 182

Query: 115 HVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKL 171
            +   D   +    Q  T+   RFYM E + A++  H +G +HR +KP N++ID     +
Sbjct: 183 FLPGGDLMTMLIRWQLFTEDVTRFYMAECILAIETIHKLGFIHRAIKPDNILIDIRGH-I 241

Query: 172 RLIDWGLAEFYHPGQEYN 189
           +L D+GL+  +H   + N
Sbjct: 242 KLSDFGLSTGFHKTHDSN 259



 Score = 99.7 bits (247), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 39/205 (19%), Positives = 65/205 (31%), Gaps = 46/205 (22%)

Query: 190 VRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVL 249
             V +  +  PE+ + YQ Y    D WSLG ++   +    PF       +   +I    
Sbjct: 322 STVGTPDYIAPEIFL-YQGYGQECDWWSLGAIMYECLIGWPPFCS-ETPQETYRKIMNFE 379

Query: 250 GTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDH 309
            T    D I                                  +S EA D + +LL +  
Sbjct: 380 QTLQFPDDIH---------------------------------ISYEAEDLIRRLLTH-A 405

Query: 310 QSRL----TAREAMEHPYFYTVVKDQAR-MGSSSMPGGSTPVSSANM-MSGISSVPTPSP 363
             RL     A E   HP+F  V  +  R + +  +P  S+   +       + +VP    
Sbjct: 406 DQRLGRHGGADEIKSHPFFRGVDWNTIRQVEAPYIPKLSSITDTRFFPTDELENVPDSPA 465

Query: 364 LGPLAGS----PVIAAANPLGMPVP 384
           +   A           + P+   +P
Sbjct: 466 MAQAAKQREQMTKQGGSAPVKEDLP 490


>3MY0-A nrPDB
          Length = 305

 Score =  155 bits (391), Expect = 4e-38,   Method: Composition-based stats.
 Identities = 66/309 (21%), Positives = 111/309 (35%), Gaps = 64/309 (20%)

Query: 41  LVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILEN-LRGGPNIITLA- 98
           LV  +G+G+Y EV+  +   + E V VKI     ++   RE +I    L    NI+    
Sbjct: 12  LVECVGKGRYGEVWRGLW--HGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIA 69

Query: 99  -DIVKDPVSRTPALVFEHVNNTDFKQLY--QTLTDYDIRFYMYEILKALDYCH------- 148
            D+     S    L+  +  +         QTL  +            L + H       
Sbjct: 70  SDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEIFGTQ 129

Query: 149 -SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEY-----NVRVASRYFKGPEL 202
               I HRD K  NV++   + +  + D GLA  +  G +Y     N RV ++ +  PE+
Sbjct: 130 GKPAIAHRDFKSRNVLVKS-NLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEV 188

Query: 203 LVD------YQMYDYSLDMWSLGCMLASMIFR----------KEPFFHGHDNYDQLVRIA 246
           L +      ++ Y    D+W+ G +L  +  R          + PF+    N      + 
Sbjct: 189 LDEQIRTDCFESY-KWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFEDMK 247

Query: 247 KVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLR 306
           KV+  +     I    +  DP  +  L +  R+ W                         
Sbjct: 248 KVVCVDQQTPTIPN-RLAADPVLSG-LAQMMRECWYP----------------------- 282

Query: 307 YDHQSRLTA 315
            +  +RLTA
Sbjct: 283 -NPSARLTA 290


>1PY5-A nrPDB
          Length = 326

 Score =  152 bits (385), Expect = 2e-37,   Method: Composition-based stats.
 Identities = 48/274 (17%), Positives = 103/274 (37%), Gaps = 38/274 (13%)

Query: 41  LVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLR-GGPNIITLA- 98
           L   +G+G++ EV+        E+V VKI    +++   RE +I + +     NI+    
Sbjct: 33  LQESIGKGRFGEVWRGKWR--GEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIA 90

Query: 99  -DIVKDPVSRTPALVFEHVNNTDFKQLYQ--TLTDYDIRFYMYEILKALDYCH------- 148
            D   +       LV ++  +          T+T   +          L + H       
Sbjct: 91  ADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQ 150

Query: 149 -SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEY-----NVRVASRYFKGPEL 202
               I HRD+K  N+++  ++    + D GLA  +    +      N RV ++ +  PE+
Sbjct: 151 GKPAIAHRDLKSKNILV-KKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEV 209

Query: 203 L---VDYQMYD--YSLDMWSLGCMLASMIFRKE----------PFFHGHDNYDQLVRIAK 247
           L   ++ + ++     D++++G +   +  R            P++    +   +  + K
Sbjct: 210 LDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRK 269

Query: 248 VLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRW 281
           V+  + L   I             ++ +  R+ W
Sbjct: 270 VVCEQKLRPNIPNRWQSC--EALRVMAKIMRECW 301


>3AOX-A nrPDB
          Length = 344

 Score =  152 bits (385), Expect = 2e-37,   Method: Composition-based stats.
 Identities = 50/275 (18%), Positives = 93/275 (33%), Gaps = 38/275 (13%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAI-----NITNNEKVVVKILKPVKKKK----IKREIKILE 86
           + +  L+R LG G + EV+E       N  +  +V VK L  V  ++       E  I+ 
Sbjct: 46  RKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIIS 105

Query: 87  NLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ----------TLTDYDIRFY 136
                 NI+    +     S    ++ E +   D K   +          +L   D+   
Sbjct: 106 KF-NHQNIVRCIGV--SLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHV 162

Query: 137 MYEILKALDYCHSMGIMHRDVKPHNVMID--HEHRKLRLIDWGLAEFYHPGQEYNVRVAS 194
             +I     Y      +HRD+   N ++      R  ++ D+G+A   +    Y     +
Sbjct: 163 ARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCA 222

Query: 195 RY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGT 251
                +  PE  ++  ++    D WS G +L  +       +    N + L  +      
Sbjct: 223 MLPVKWMPPEAFME-GIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRM 281

Query: 252 EDLYDYID----------KYNIELDPRFNDILGRH 276
           +   +             ++  E  P F  IL R 
Sbjct: 282 DPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERI 316


>4F0G-A nrPDB
          Length = 287

 Score =  152 bits (383), Expect = 3e-37,   Method: Composition-based stats.
 Identities = 47/271 (17%), Positives = 111/271 (40%), Gaps = 34/271 (12%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP----------VKKKKIKREIKILE 86
           ++ +  +++G+G +  V +   + +   V +K L             K ++ +RE+ I+ 
Sbjct: 19  NEIEYEKQIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQREVFIMS 78

Query: 87  NLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY----QTLTDYDIRFYMYEILK 142
           NL   PNI+ L  ++ +P      +V E V   D           +        M +I  
Sbjct: 79  NL-NHPNIVKLYGLMHNPPR----MVMEFVPCGDLYHRLLDKAHPIKWSVKLRLMLDIAL 133

Query: 143 ALDYCHSMG--IMHRDVKPHNVMIDH--EHRKL--RLIDWGLAEFYHPGQEYNVRVASRY 196
            ++Y  +    I+HRD++  N+ +    E+  +  ++ D+GL++        +  + +  
Sbjct: 134 GIEYMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQ--QSVHSVSGLLGNFQ 191

Query: 197 FKGPELL-VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLY 255
           +  PE +  + + Y    D +S   +L +++  + PF    +     ++   ++  E L 
Sbjct: 192 WMAPETIGAEEESYTEKADTYSFAMILYTILTGEGPF---DEYSYGKIKFINMIREEGLR 248

Query: 256 DYIDKYNIELDPRFNDILGRHSRKRWERFVH 286
             I +   +  PR  +++        ++  H
Sbjct: 249 PTIPE---DCPPRLRNVIELCWSGDPKKRPH 276


>5WNL-A nrPDB
          Length = 342

 Score =  151 bits (382), Expect = 4e-37,   Method: Composition-based stats.
 Identities = 56/344 (16%), Positives = 135/344 (39%), Gaps = 57/344 (16%)

Query: 43  RKLGRGKYSEVFEAINITNNEKVVVKI-----LKPVKKKKIKREIKILENLRGGPNIITL 97
            K+G G + +V++  ++     + +K      +   ++ ++  E K +E  +    I+ +
Sbjct: 26  EKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRERMELLEEAKKMEMAK-FRYILPV 84

Query: 98  ADIVKDPVSRTPALVFEHVNNTDFKQLYQTLT-DYDIRF-YMYEILKALDYCHSMG--IM 153
             I ++PV     LV E++     ++L  +    +D+RF  ++E    +++ H M   ++
Sbjct: 85  YGICQEPVG----LVMEYMETGSLEKLLASEPLPWDLRFRIVHETAVGMNFLHCMSPPLL 140

Query: 154 HRDVKPHNVMIDHEHRKLRLIDWGLAEF----YHPGQEYNVRVASRYFKGPELLVD-YQM 208
           H ++KP N+++D  H  +++ D+GLA+     +      +    +  +  PE + +  ++
Sbjct: 141 HLNLKPANILLDA-HYHVKISDFGLAKCNGMSHSHDLSMDGLFGTIAYLPPERIREKSRL 199

Query: 209 YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPR 268
           +D   D++S   ++  ++ +K+PF    +    ++++ K                   P 
Sbjct: 200 FDTKHDVYSFAIVIWGVLTQKKPFADEKNILHIMMKVVKG----------------HRPE 243

Query: 269 FNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVV 328
              I     R                   +  + +    D Q R T +E        +  
Sbjct: 244 LPPICRPRPRAC--------------ASLIGLMQRCWHADPQVRPTFQE------ITSET 283

Query: 329 KDQARMGSSSMPGGS-TPVSSANMMSGISSVPTPSPLGPLAGSP 371
           +D        +   +  P   +++ S   + P  S L   +  P
Sbjct: 284 EDLCEKPDEEVKDLAHEPGEKSSLESKSEARPESSRLKRASAPP 327


>3UIM-A nrPDB
          Length = 326

 Score =  151 bits (382), Expect = 4e-37,   Method: Composition-based stats.
 Identities = 50/243 (20%), Positives = 94/243 (38%), Gaps = 26/243 (10%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK----KIKREIKILENLRGGP 92
           D++     LGRG + +V++   + +   V VK LK  + +    + + E++++       
Sbjct: 30  DNFSNKNILGRGGFGKVYKGR-LADGTLVAVKRLKEERTQGGELQFQTEVEMISMAVH-R 87

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYD-------IRFYMYEILKALD 145
           N++ L      P  R   LV+ ++ N       +   +          +       + L 
Sbjct: 88  NLLRLRGFCMTPTER--LLVYPYMANGSVASCLRERPESQPPLDWPKRQRIALGSARGLA 145

Query: 146 YCHSM---GIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF--YHPGQEYNVRVASRYFKGP 200
           Y H      I+HRDVK  N+++D E   + + D+GLA+   Y           +     P
Sbjct: 146 YLHDHCDPKIIHRDVKAANILLDEEFEAV-VGDFGLAKLMDYKDTHVTTAVRGTIGHIAP 204

Query: 201 ELLVDYQMYDYSLDMWSLGCMLASMIFRKEPF----FHGHDNYDQLVRIAKVLGTEDLYD 256
           E L   +      D++  G ML  +I  +  F        D+   L  +  +L  + L  
Sbjct: 205 EYLSTGKS-SEKTDVFGYGVMLLELITGQRAFDLARLANDDDVMLLDWVKGLLKEKKLEA 263

Query: 257 YID 259
            +D
Sbjct: 264 LVD 266


>6J5U-C nrPDB
          Length = 426

 Score =  151 bits (381), Expect = 5e-37,   Method: Composition-based stats.
 Identities = 69/369 (18%), Positives = 127/369 (34%), Gaps = 61/369 (16%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITN---------NEKVVVKILKP---VKKKKIKREIKIL 85
           +++    LG G +  VF+                  V VK LKP      K+   E+  L
Sbjct: 85  NFRQDNLLGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQLKPEGFQGHKEWLTEVNYL 144

Query: 86  ENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY-----QTLTDYDIRFYMYEI 140
             L   PN++ L     +  +R   LV+E +     +        Q LT           
Sbjct: 145 GQLSH-PNLVLLVGYCAEGENR--LLVYEFMPKGSLENHLFRRGAQPLTWAIRMKVAVGA 201

Query: 141 LKALDYCHSMG--IMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVR---VASR 195
            K L + H     +++RD K  N+++D +    +L D+GLA+    G   +V    + + 
Sbjct: 202 AKGLTFLHEAKSQVIYRDFKAANILLDAD-FNAKLSDFGLAKAGPTGDNTHVSTKVIGTH 260

Query: 196 YFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLY 255
            +  PE +   ++     D++S G +L  +I  +       DN       +       L 
Sbjct: 261 GYAAPEYVATGRL-TAKSDVYSFGVVLLELISGR----RAMDN-------SNGGNEYSLV 308

Query: 256 DYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTA 315
           D+   Y  +    F  +  +   +  ++   +         A +   + L  D + R   
Sbjct: 309 DWATPYLGDKRKLFRIMDTKLGGQYPQKGAFT---------AANLALQCLNPDAKLRPKM 359

Query: 316 REAM----EHPYFYTVVKDQARMGSSSMPG-------GSTPVSSANMMSGISSVPTPSPL 364
            E +    +     +V K   +      P          +PV  ++    +   P  SPL
Sbjct: 360 SEVLVTLEQ---LESVAKPGTKHTQMESPRFHHSSVMQKSPVRYSHDRPLLHMTPGASPL 416

Query: 365 GPLAGSPVI 373
                SP +
Sbjct: 417 PSYTQSPRV 425


>3G2F-A nrPDB
          Length = 336

 Score =  150 bits (380), Expect = 7e-37,   Method: Composition-based stats.
 Identities = 57/310 (18%), Positives = 111/310 (35%), Gaps = 45/310 (14%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILEN-LRGGPNII 95
           D+ +L+  +GRG+Y  V++     +   V VK+     ++    E  I    L    NI 
Sbjct: 13  DNLKLLELIGRGRYGAVYKG--SLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIA 70

Query: 96  TLA---DIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIR--FYMYEILKALDYCH-- 148
                 + V         LV E+  N    +     T   +      + + + L Y H  
Sbjct: 71  RFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTE 130

Query: 149 -------SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA------EFYHPGQEYN---VRV 192
                     I HRD+   NV++ ++   + + D+GL+          PG+E N     V
Sbjct: 131 LPRGDHYKPAISHRDLNSRNVLVKNDGTCV-ISDFGLSMRLTGNRLVRPGEEDNAAISEV 189

Query: 193 ASRYFKGPELLVD------YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIA 246
            +  +  PE+L         +     +DM++LG +   +  R    F G    +  +   
Sbjct: 190 GTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVPEYQMAFQ 249

Query: 247 KVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLR 306
             +G    ++ +             +L    ++R +     +   L      + ++    
Sbjct: 250 TEVGNHPTFEDM------------QVLVSREKQRPKFPEAWKENSLAVRSLKETIEDCWD 297

Query: 307 YDHQSRLTAR 316
            D ++RLTA+
Sbjct: 298 QDAEARLTAQ 307


>5LPZ-A nrPDB
          Length = 332

 Score =  150 bits (378), Expect = 1e-36,   Method: Composition-based stats.
 Identities = 51/256 (19%), Positives = 100/256 (39%), Gaps = 22/256 (8%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK---KIKREIKILENLRGGPNII 95
           +     +G G + +V++AI   +   V +K L  V  +   +   E++ +  ++   N++
Sbjct: 19  FHNDSLIGSGGFGDVYKAILK-DGSAVAIKKLIHVSGQGDREFMAEMETIGKIKH-RNLV 76

Query: 96  TLADIVKDPVSRTPALVFEHVNNTDFKQLYQ-------TLTDYDIRFYMYEILKALDYCH 148
            L    K  V     LV+E +     + +          L     R       + L + H
Sbjct: 77  PLLGYCK--VGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLH 134

Query: 149 SM---GIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEY---NVRVASRYFKGPEL 202
                 I+HRD+K  NV++D E+ + R+ D+G+A        +   +    +  +  PE 
Sbjct: 135 HNCSPHIIHRDMKSSNVLLD-ENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEY 193

Query: 203 LVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYN 262
              ++      D++S G +L  ++  K P        + LV   K      + D  D   
Sbjct: 194 YQSFR-CSTKGDVYSYGVVLLELLTGKRPTDSPDFGDNNLVGWVKQHAKLRISDVFDPEL 252

Query: 263 IELDPRFNDILGRHSR 278
           ++ DP     L +H +
Sbjct: 253 MKEDPALEIELLQHLK 268


>5C26-A nrPDB
          Length = 299

 Score =  150 bits (378), Expect = 1e-36,   Method: Composition-based stats.
 Identities = 60/298 (20%), Positives = 121/298 (40%), Gaps = 42/298 (14%)

Query: 11  VYTDVNTHRPRE-YWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAIN--ITNNEKVVV 67
            Y D    RP+E Y D +   +E          ++LG G +  V +         + V V
Sbjct: 9   PYADPEEIRPKEVYLDRKLLTLE---------DKELGSGNFGTVKKGYYQMKKVVKTVAV 59

Query: 68  KILK-----PVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFK 122
           KILK     P  K ++  E  +++ L   P I+ +  I +   + +  LV E        
Sbjct: 60  KILKNEANDPALKDELLAEANVMQQLDN-PYIVRMIGICE---AESWMLVMEMAELGPLN 115

Query: 123 QLYQT---LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA 179
           +  Q    + D +I   ++++   + Y      +HRD+   NV++  +H   ++ D+GL+
Sbjct: 116 KYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYA-KISDFGLS 174

Query: 180 EFYHPGQE-YNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMI-FRKEPF-- 232
           +     +  Y  +   ++   +  PE + +Y  +    D+WS G ++     + ++P+  
Sbjct: 175 KALRADENYYKAQTHGKWPVKWYAPECI-NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRG 233

Query: 233 FHGHDNYDQLVRIAKVLGTE--------DLYDYIDKYNIELDPRFNDILGRHSRKRWE 282
             G +    L +  + +G          DL +    Y++E  P F  +  R     ++
Sbjct: 234 MKGSEVTAMLEKGER-MGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYD 290


>4FL3-A nrPDB
          Length = 635

 Score =  150 bits (378), Expect = 1e-36,   Method: Composition-based stats.
 Identities = 59/298 (19%), Positives = 121/298 (40%), Gaps = 42/298 (14%)

Query: 11  VYTDVNTHRPRE-YWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAIN--ITNNEKVVV 67
            + D    RP+E Y D +   +E          ++LG G +  V +         + V V
Sbjct: 351 PFADPEEIRPKEVYLDRKLLTLE---------DKELGSGNFGTVKKGYYQMKKVVKTVAV 401

Query: 68  KILK-----PVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFK 122
           KILK     P  K ++  E  +++ L   P I+ +  I +   + +  LV E        
Sbjct: 402 KILKNEANDPALKDELLAEANVMQQLDN-PYIVRMIGICE---AESWMLVMEMAELGPLN 457

Query: 123 QLYQT---LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA 179
           +  Q    + D +I   ++++   + Y      +HRD+   NV++  +H   ++ D+GL+
Sbjct: 458 KYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYA-KISDFGLS 516

Query: 180 EFYHPGQE-YNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMI-FRKEPF-- 232
           +     +  Y  +   ++   +  PE + +Y  +    D+WS G ++     + ++P+  
Sbjct: 517 KALRADENYYKAQTHGKWPVKWYAPECI-NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRG 575

Query: 233 FHGHDNYDQLVRIAKVLGTE--------DLYDYIDKYNIELDPRFNDILGRHSRKRWE 282
             G +    L +  + +G          DL +    Y++E  P F  +  R     ++
Sbjct: 576 MKGSEVTAMLEKGER-MGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYD 632


>5LPV-A nrPDB
          Length = 296

 Score =  149 bits (376), Expect = 2e-36,   Method: Composition-based stats.
 Identities = 51/256 (19%), Positives = 101/256 (39%), Gaps = 22/256 (8%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK---KIKREIKILENLRGGPNII 95
           +     +G G + +V++AI + +   V +K L  V  +   +   E++ +  ++   N++
Sbjct: 19  FHNDSLIGSGGFGDVYKAI-LKDGSAVAIKKLIHVSGQGDREFMAEMETIGKIKH-RNLV 76

Query: 96  TLADIVKDPVSRTPALVFEHVNNTDFKQLYQ-------TLTDYDIRFYMYEILKALDYCH 148
            L    K  V     LV+E +     + +          L     R       + L + H
Sbjct: 77  PLLGYCK--VGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLH 134

Query: 149 SM---GIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEY---NVRVASRYFKGPEL 202
                 I+HRD+K  NV++D E+ + R+ D+G+A        +   +    +  +  PE 
Sbjct: 135 HNCSPHIIHRDMKSSNVLLD-ENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEY 193

Query: 203 LVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYN 262
              ++      D++S G +L  ++  K P        + LV   K      + D  D   
Sbjct: 194 YQSFR-CSTKGDVYSYGVVLLELLTGKRPTDSPDFGDNNLVGWVKQHAKLRISDVFDPEL 252

Query: 263 IELDPRFNDILGRHSR 278
           ++ DP     L +H +
Sbjct: 253 MKEDPALEIELLQHLK 268


>2H34-A nrPDB
          Length = 309

 Score =  149 bits (376), Expect = 2e-36,   Method: Composition-based stats.
 Identities = 50/221 (22%), Positives = 97/221 (43%), Gaps = 16/221 (7%)

Query: 23  YWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK------PVKKK 76
           + D  +   E      Y+L R +GRG   +V+EA +      V +K++       PV + 
Sbjct: 20  HMDGTAESREGTQFGPYRLRRLVGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPVFRT 79

Query: 77  KIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDI 133
           +++RE +    L+  P+++ + D  +  +     +    +N  D   + +    L     
Sbjct: 80  RMQREARTAGRLQ-EPHVVPIHDFGE--IDGQLYVDMRLINGVDLAAMLRRQGPLAPPRA 136

Query: 134 RFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ--EYNVR 191
              + +I  ALD  H+ G  HRDVKP N+++  +     L+D+G+A      +  +    
Sbjct: 137 VAIVRQIGSALDAAHAAGATHRDVKPENILVSADDFAY-LVDFGIASATTDEKLTQLGNT 195

Query: 192 VASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPF 232
           V + Y+  PE   +     Y  D+++L C+L   +    P+
Sbjct: 196 VGTLYYMAPERFSESHA-TYRADIYALTCVLYECLTGSPPY 235


>3QD2-B nrPDB
          Length = 332

 Score =  147 bits (372), Expect = 5e-36,   Method: Composition-based stats.
 Identities = 60/344 (17%), Positives = 119/344 (34%), Gaps = 102/344 (29%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK----PVKKKKIKREIKILENLRGGPN 93
           D++ ++ +GRG +  VFEA N  ++    +K ++     + ++K+ RE+K L  L   P 
Sbjct: 7   DFEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEH-PG 65

Query: 94  I---------------------ITLADIVKD----------------------------- 103
           I                     I L D   D                             
Sbjct: 66  IVRYFNAWLETPPEKWQEEMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFSTKNTVG 125

Query: 104 -----PVSRTPALVFEHVNNTDFKQLYQ---TLTDYD---IRFYMYEILKALDYCHSMGI 152
                       +  +     + K       +L D +         +I +A+++ HS G+
Sbjct: 126 QLQPSSPKVYLYIQMQLCRKENLKDWMNRRCSLEDREHGVCLHIFIQIAEAVEFLHSKGL 185

Query: 153 MHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE-------------YNVRVASRYFKG 199
           MHRD+KP N+    +   +++ D+GL       +E             +  +V ++ +  
Sbjct: 186 MHRDLKPSNIFFTMDD-VVKVGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQVGTKLYMS 244

Query: 200 PELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYID 259
           PE +     Y + +D++SLG +L  +++             Q+ R+  +          D
Sbjct: 245 PEQIHGNN-YSHKVDIFSLGLILFELLY---------SFSTQMERVRII---------TD 285

Query: 260 KYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDK 303
             N++    F     +      +    S  +    PEA D ++ 
Sbjct: 286 VRNLKFPLLFTQKYPQEHMMVQDMLSPSPTER---PEATDIIEN 326


>3LMG-A nrPDB
          Length = 344

 Score =  146 bits (369), Expect = 1e-35,   Method: Composition-based stats.
 Identities = 47/288 (16%), Positives = 114/288 (39%), Gaps = 30/288 (10%)

Query: 16  NTHRPREYWDYESHVVE-WGNQDDYQLVRKLGRGKYSEVFEAINITNNE----KVVVKIL 70
            +  P +  +  + V+     + + + ++ LG G +  V + + I   E     V +K++
Sbjct: 9   ESIEPLDPSEKANKVLARIFKETELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVI 68

Query: 71  KPVKKKKIKREIKILENL---RGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ- 126
           +    ++  + +             +I+ L  +       +  LV +++         + 
Sbjct: 69  EDKSGRQSFQAVTDHMLAIGSLDHAHIVRLLGLC---PGSSLQLVTQYLPLGSLLDHVRQ 125

Query: 127 ---TLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH 183
               L    +  +  +I K + Y    G++HR++   NV++     ++++ D+G+A+   
Sbjct: 126 HRGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKSPS-QVQVADFGVADLLP 184

Query: 184 PGQE---YNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLAS-MIFRKEPF--FHGHD 237
           P  +   Y+       +   E +  +  Y +  D+WS G  +   M F  EP+      +
Sbjct: 185 PDDKQLLYSEAKTPIKWMALESI-HFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAE 243

Query: 238 NYDQLVRIAKV----LGTEDLYDYIDKYNI---ELDPRFNDILGRHSR 278
             D L +  ++    + T D+Y  + K  +    + P F ++    +R
Sbjct: 244 VPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKELANEFTR 291


>5WNO-A nrPDB
          Length = 330

 Score =  145 bits (367), Expect = 2e-35,   Method: Composition-based stats.
 Identities = 47/284 (16%), Positives = 104/284 (36%), Gaps = 29/284 (10%)

Query: 40  QLVRKLGRGKYSEVFEAIN-----ITNNEKVVVKILKPVKKK--KIKREIKILENLRGGP 92
           +L +KLG G +  VF  I            V +K+ +  + +  ++  E   +  LR   
Sbjct: 25  KLDKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTDQSQTDEMLEEATNMFRLRHD- 83

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTD----YDIRFYMYEILKALDYCH 148
           N++ +             +V  +    + +   +   +     +   Y Y+I   + Y  
Sbjct: 84  NLLKIIGFC--MHDDGLKIVTIYRPLGNLQNFLKLHKENLGAREQVLYCYQIASGMQYLE 141

Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFY-HPGQEYNVRVASRY--FKGPELLVD 205
              ++HRD+   NV++  +   + + D+GL++   H      ++       +   E+   
Sbjct: 142 KQRVVHRDLATRNVLV-KKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIEIFSK 200

Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHG--HDNYDQLVRIAKVLGTE-----DLYDYI 258
           +  Y ++ D+W+ G     +I   +  + G   D+    ++    L        DLY  +
Sbjct: 201 HC-YTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQPPNCSQDLYQEL 259

Query: 259 DKY---NIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALD 299
            +    + +  P F  +  R         +  EN + +S   L 
Sbjct: 260 LRCWMADPKSRPGFEILYERFKEFCKVPQLFLENSNKISESDLS 303


>3SOC-A nrPDB
          Length = 322

 Score =  144 bits (364), Expect = 5e-35,   Method: Composition-based stats.
 Identities = 60/315 (19%), Positives = 117/315 (37%), Gaps = 50/315 (15%)

Query: 31  VEWGNQDDY------QLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKI 84
           V+ G ++ Y      QL+    RG++  V++A  +  NE V VKI     K+  + E ++
Sbjct: 12  VDLGTENLYFQSMPLQLLEVKARGRFGCVWKAQLL--NEYVAVKIFPIQDKQSWQNEYEV 69

Query: 85  LENL--RGGPNIITLADIVK--DPVSRTPALVFEHVNNTDFKQLYQT--LTDYDIRFYMY 138
              L      NI+      K    V     L+             +   ++  ++     
Sbjct: 70  YS-LPGMKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAE 128

Query: 139 EILKALDYCHS----------MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ-- 186
            + + L Y H             I HRD+K  NV++ + +    + D+GLA  +  G+  
Sbjct: 129 TMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKN-NLTACIADFGLALKFEAGKSA 187

Query: 187 -EYNVRVASRYFKGPELLVDYQMYDY----SLDMWSLGCMLASMIFRKEPFFHGHDNYDQ 241
            + + +V +R +  PE+L     +       +DM+++G +L  +  R             
Sbjct: 188 GDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCT----------- 236

Query: 242 LVRIAKVLGTEDLYDYIDKYNIELDPRFNDILG-RHSRKRWERFVHSENQHLVSPEALDF 300
                   G  D Y    +  I   P   D+      +K+         +H       + 
Sbjct: 237 -----AADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCET 291

Query: 301 LDKLLRYDHQSRLTA 315
           +++   +D ++RL+A
Sbjct: 292 IEECWDHDAEARLSA 306


>4TN6-A nrPDB
          Length = 318

 Score =  142 bits (357), Expect = 4e-34,   Method: Composition-based stats.
 Identities = 49/256 (19%), Positives = 99/256 (38%), Gaps = 19/256 (7%)

Query: 31  VEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKI-LKPVKKKKIKREIKILENLR 89
           +E    + Y+L RK+G G + +++   +I   E+V +K+     K  ++  E KI + ++
Sbjct: 1   MELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQ 60

Query: 90  GGPNIITLADIVKDPVSRTPALVFEHVN---NTDFKQLYQTLTDYDIRFYMYEILKALDY 146
           GG  I T+             +V E +       F    +  +   +     +++  ++Y
Sbjct: 61  GGVGIPTIRWC--GAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEY 118

Query: 147 CHSMGIMHRDVKPHNVM--IDHEHRKLRLIDWGLAEFYHPGQEY--------NVRVASRY 196
            HS   +HRDVKP N +  +  +   + +ID+GLA+ Y   + +             +  
Sbjct: 119 IHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTAR 178

Query: 197 FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPF--FHGHDNYDQLVRIAKVLGTEDL 254
           +      +  +      D+ SLG +L        P+          +  RI++   +  +
Sbjct: 179 YASINTHLGIEQ-SRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPI 237

Query: 255 YDYIDKYNIELDPRFN 270
                 Y  E     N
Sbjct: 238 EVLCKGYPSEFATYLN 253


>3SV0-A nrPDB
          Length = 483

 Score =  140 bits (354), Expect = 7e-34,   Method: Composition-based stats.
 Identities = 52/282 (18%), Positives = 104/282 (36%), Gaps = 30/282 (10%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK-PVKKKKIKREIKILENLRGGPNI- 94
           + ++L RK+G G + E++   NI  NE+V +K+     K  ++  E KI   L+GG  I 
Sbjct: 7   NKFRLGRKIGSGSFGEIYLGTNIQTNEEVAIKLENVKTKHPQLLYESKIYRILQGGTGIP 66

Query: 95  -ITLADIVKDPVSRTPALVFEHVN---NTDFKQLYQTLTDYDIRFYMYEILKALDYCHSM 150
            +    +          LV + +       F    + L+   +     +++  +++ HS 
Sbjct: 67  NVRWFGV----EGDYNVLVMDLLGPSLEDLFNFCSRKLSLKTVLMLADQMINRVEFVHSK 122

Query: 151 GIMHRDVKPHNVM--IDHEHRKLRLIDWGLAEFYHPGQEY--------NVRVASRYFKGP 200
             +HRD+KP N +  +     ++ +ID+GLA+ Y     +             +  +   
Sbjct: 123 SFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDTSTHQHIPYRENKNLTGTARYASV 182

Query: 201 ELLVDYQMYDYSLDMWSLGCMLASMIFRKEPF--FHGHDNYDQLVRIAKVLGTEDLYDYI 258
              +  +      D+ SLG +L   +    P+          +  +I++      +    
Sbjct: 183 NTHLGIEQ-SRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKYEKISEKKVATSIEALC 241

Query: 259 DKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDF 300
             Y  E    F+         R  RF    +   +     D 
Sbjct: 242 RGYPTEFASYFH-------YCRSLRFDDKPDYSYLKRLFRDL 276


>2CHL-A nrPDB
          Length = 351

 Score =  140 bits (354), Expect = 8e-34,   Method: Composition-based stats.
 Identities = 55/283 (19%), Positives = 110/283 (38%), Gaps = 27/283 (9%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK--KIKREIKILENLRGGPNII 95
           ++++ +K+G G + E+    N+  NE V +K L+P+K +  ++  E +  + L  G  I 
Sbjct: 31  NFRVGKKIGCGNFGELRLGKNLYTNEYVAIK-LEPMKSRAPQLHLEYRFYKQLGSGDGIP 89

Query: 96  TLADIVKDPVSRTPALVFEHVN---NTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGI 152
            +      P  +  A+V E +       F    +T +   +     +++  ++Y HS  +
Sbjct: 90  QVYYF--GPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNL 147

Query: 153 MHRDVKPHNVMIDHEHRK----LRLIDWGLAEFY--------HPGQEYNVRVASRYFKGP 200
           ++RDVKP N +I     K    + +ID+ LA+ Y         P +E+     +  +   
Sbjct: 148 IYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSI 207

Query: 201 ELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDK 260
              +  +      D+ +LG M    +    P+       D L    + +G       I+ 
Sbjct: 208 NTHLGKEQ-SRRDDLEALGHMFMYFLRGSLPWQGLK--ADTLKERYQKIGDTKRATPIEV 264

Query: 261 YNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDK 303
               L   F ++       R   F    +   +     D  D+
Sbjct: 265 ----LCENFPEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDR 303


>5XD6-A nrPDB
          Length = 305

 Score =  140 bits (352), Expect = 1e-33,   Method: Composition-based stats.
 Identities = 41/225 (18%), Positives = 84/225 (37%), Gaps = 26/225 (11%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK--KKIKREIKILENLRGGPNI 94
           D+Y     +G G Y  VF  I   + +   +K L   K+  ++   ++ ++  LR   N+
Sbjct: 22  DNYGSKSLIGEGSYGRVFYGILK-SGKAAAIKKLDSSKQPDQEFLAQVSMVSRLRQ-ENV 79

Query: 95  ITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ------------TLTDYDIRFYMYEILK 142
           + L     D   R   L +E+  N     +               L+ +          +
Sbjct: 80  VALLGYCVDGPLR--VLAYEYAPNGSLHDILHGRKGVKGAQPGPVLSWHQRVKIAVGAAR 137

Query: 143 ALDYCHSM---GIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ---EYNVRVASRY 196
            L+Y H      ++HRD+K  NV++  +    ++ D+ L+               + +  
Sbjct: 138 GLEYLHEKANPHVIHRDIKSSNVLLFDDD-VAKIADFDLSNQAPDMAARLHSTRVLGTFG 196

Query: 197 FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQ 241
           +  PE  +   +     D++S G +L  ++  ++P  H      Q
Sbjct: 197 YHAPEYAMTGTL-STKSDVYSFGVVLLELLTGRKPVDHTLPRGQQ 240


>5AR8-A nrPDB
          Length = 326

 Score =  140 bits (352), Expect = 1e-33,   Method: Composition-based stats.
 Identities = 59/303 (19%), Positives = 118/303 (38%), Gaps = 44/303 (14%)

Query: 42  VRKLGRGKYSEVFEAINITNNEKVVVKILK------PVKKKKIKREIKILENLRGGPNII 95
           +R L RG    V  A +     +V VK L         ++K + RE +IL   R    I+
Sbjct: 37  LRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKAR-FSYIL 95

Query: 96  TLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTD-----YDIRF-YMYEILKALDYCHS 149
            +  I  +P      +V E++ N    +L    T+     + +RF  ++EI   ++Y H+
Sbjct: 96  PILGICNEP--EFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHN 153

Query: 150 MG--IMHRDVKPHNVMIDHEHRKLRLIDWGLAEF------YHPGQEYNVRVASRYFKGPE 201
           M   ++H D+K  N+++D+E   +++ D+GL+++           +      +  +  PE
Sbjct: 154 MTPPLLHHDLKTQNILLDNE-FHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPE 212

Query: 202 LLVDYQMY--DYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYID 259
                Q        D++S   +   ++ RK+PF    +    +  +++          I+
Sbjct: 213 NYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQ-----GHRPVIN 267

Query: 260 KYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSR----LTA 315
           + ++  D      +       W +                FL  L+  +   R    +T 
Sbjct: 268 EESLPYDIPHRARMISLIESGWAQNPDERPS---------FLKCLIELEPVLRTFEEITF 318

Query: 316 REA 318
            EA
Sbjct: 319 LEA 321


>2Y4I-B nrPDB
          Length = 319

 Score =  139 bits (350), Expect = 2e-33,   Method: Composition-based stats.
 Identities = 56/329 (17%), Positives = 115/329 (34%), Gaps = 59/329 (17%)

Query: 20  PREYWDYESHVVEWGNQ-DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL-----KPV 73
           PR+       + EW    +  ++   +G+G++ +V+       + +V ++++        
Sbjct: 15  PRKASQTSIFLQEWDIPFEQLEIGELIGKGRFGQVYHGRW---HGEVAIRLIDIERDNED 71

Query: 74  KKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ----TLT 129
           + K  KRE+      R   N++        P     A++           + +     L 
Sbjct: 72  QLKAFKREVMAYRQTRH-ENVVLFMGACMSPP--HLAIITSLCKGRTLYSVVRDAKIVLD 128

Query: 130 DYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGL---AEFYHPGQ 186
               R    EI+K + Y H+ GI+H+D+K  NV   +++ K+ + D+GL   +     G+
Sbjct: 129 VNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVF--YDNGKVVITDFGLFSISGVLQAGR 186

Query: 187 EYNVRVASRYF---KGPELLVDYQ--------MYDYSLDMWSLGCMLASMIFRKEPFFHG 235
             +       +     PE++             +    D+++LG +   +  R+ PF   
Sbjct: 187 REDKLRIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPF--- 243

Query: 236 HDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSP 295
                          T+     I +    + P  + I           F  +  Q    P
Sbjct: 244 --------------KTQPAEAIIWQMGTGMKPNLSQIGMGKEISDILLFCWAFEQEER-P 288

Query: 296 EALDFLDKLLRYDHQ--SRLTAREAMEHP 322
                +D +L    +   RL+      HP
Sbjct: 289 TFTKLMD-MLEKLPKRNRRLS------HP 310


>2QKW-B nrPDB
          Length = 321

 Score =  138 bits (349), Expect = 3e-33,   Method: Composition-based stats.
 Identities = 47/287 (16%), Positives = 109/287 (37%), Gaps = 38/287 (13%)

Query: 45  LGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLR--GGPNIITLADIVK 102
           +G G + +V++ + + +  KV +K   P   + I+     +E L     P++++L     
Sbjct: 47  IGHGVFGKVYKGV-LRDGAKVALKRRTPESSQGIEEFETEIETLSFCRHPHLVSLIGFCD 105

Query: 103 DPVSRTPALVFEHVNNTDFKQLY-------QTLTDYDIRFYMYEILKALDYCHSMGIMHR 155
           +       L+++++ N + K+          +++            + L Y H+  I+HR
Sbjct: 106 E--RNEMILIYKYMENGNLKRHLYGSDLPTMSMSWEQRLEICIGAARGLHYLHTRAIIHR 163

Query: 156 DVKPHNVMIDHEHRKLRLIDWGLAE---FYHPGQEYNVRVASRYFKGPELLVDYQMYDYS 212
           DVK  N+++D E+   ++ D+G+++            V   +  +  PE  +  ++    
Sbjct: 164 DVKSINILLD-ENFVPKITDFGISKKGTELDQTHLSTVVKGTLGYIDPEYFIKGRL-TEK 221

Query: 213 LDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDI 272
            D++S G +L  ++                 R A V         + ++ +E     N  
Sbjct: 222 SDVYSFGVVLFEVLC---------------ARSAIVQSLPREMVNLAEWAVESHN--NGQ 264

Query: 273 LGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAM 319
           L +         +  E+       A+    K L    + R +  + +
Sbjct: 265 LEQIVDPNLADKIRPESLRKFGDTAV----KCLALSSEDRPSMGDVL 307


>5E8V-A nrPDB
          Length = 316

 Score =  138 bits (349), Expect = 3e-33,   Method: Composition-based stats.
 Identities = 55/305 (18%), Positives = 116/305 (38%), Gaps = 45/305 (14%)

Query: 40  QLVRKLGRGKYSEVFEAINITNN----EKVVVKILKPVKKKKIKREIKILENLR-GGPNI 94
           +L   +G+G+++EV++A    N     E V VKI    +    K E  I  ++     NI
Sbjct: 12  ELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENI 71

Query: 95  ITLADIVK--DPVSRTPALVFEHVNNTDFKQLY--QTLTDYDIRFYMYEILKALDYCHS- 149
           +      +    + +   L+       + ++      ++  D+R     + + + + HS 
Sbjct: 72  LQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSD 131

Query: 150 --------MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHP-----GQEYNVRVASRY 196
                   M I+HRD+K  N+++ ++     L D+GL+    P         + +V +  
Sbjct: 132 HTPCGRPKMPIVHRDLKSSNILVKND-LTCCLCDFGLSLRLDPTLSVDDLANSGQVGTAR 190

Query: 197 FKGPELLVDYQMYD-----YSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGT 251
           +  PE+L      +        D++S+  +L  M  R                + +V   
Sbjct: 191 YMAPEVLASAMNLENVESFKQTDVYSMALVLWEMTSRC-------------NAVGEVKDY 237

Query: 252 EDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQS 311
           E  +    + +  +    +++L    R     F  +     +  E    L +   +D ++
Sbjct: 238 EPPFGSKVREHPCVASMADNVLADAGRPEIPSFWLNHQGIQMVCET---LTECWDHDPEA 294

Query: 312 RLTAR 316
           RLTA+
Sbjct: 295 RLTAQ 299


>4BTK-A nrPDB
          Length = 337

 Score =  138 bits (347), Expect = 4e-33,   Method: Composition-based stats.
 Identities = 50/225 (22%), Positives = 104/225 (46%), Gaps = 15/225 (6%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKR-EIKILENLRGGPNI 94
           +D +++++K+G G + E++EA+++   E V +K+    + K++ + E+ +L+ L+G  ++
Sbjct: 55  KDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDHV 114

Query: 95  ITLADIVKDPVSRTPALVFEHVNNTDFK--QLYQTLTDYDIRFYMYEILKALDYCHSMGI 152
                  ++       +  +  N  D +  Q   T T         +IL++++  HS+G 
Sbjct: 115 CRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHSVGF 174

Query: 153 MHRDVKPHNVMID---HEHRKLRLIDWGLAEFY-------HPGQEYNVRVASRYFKGPEL 202
           +HRD+KP N  +      +RK  ++D+GLA  Y        P +       +  +     
Sbjct: 175 LHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRYASVNA 234

Query: 203 LVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAK 247
             + +M     D+WSL  ML      + P+    D  +Q+  I +
Sbjct: 235 HKNREM-GRHDDLWSLFYMLVEFAVGQLPWRKIKDK-EQVGMIKE 277


>5FQD-C nrPDB
          Length = 341

 Score =  137 bits (346), Expect = 6e-33,   Method: Composition-based stats.
 Identities = 50/201 (24%), Positives = 89/201 (44%), Gaps = 18/201 (8%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK-PVKKKKIKREIKILENLRGGPNIIT 96
            Y+LVRK+G G + +++ AINITN E+V VK+     +  ++  E K+ + L+GG  I  
Sbjct: 20  KYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIPH 79

Query: 97  LADIVKDPVSRTPALVFEHVN---NTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIM 153
           +    ++       LV + +       F    +  T   +     +++  ++Y H+   +
Sbjct: 80  IRWYGQEK--DYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFI 137

Query: 154 HRDVKPHNVM--IDHEHRKLRLIDWGLAEFYHPGQEY--------NVRVASRYFKGPELL 203
           HRD+KP N +  I     KL LID+GLA+ Y   +               +  +      
Sbjct: 138 HRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAH 197

Query: 204 VDYQMYDYSLDMWSLG-CMLA 223
           +  +      DM SLG  ++ 
Sbjct: 198 LGIEQ-SRRDDMESLGYVLMY 217


>4NFN-A nrPDB
          Length = 309

 Score =  137 bits (345), Expect = 8e-33,   Method: Composition-based stats.
 Identities = 50/225 (22%), Positives = 104/225 (46%), Gaps = 15/225 (6%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKR-EIKILENLRGGPNI 94
           +D +++++K+G G + E++EA+++   E V +K+    + K++ + E+ +L+ L+G  ++
Sbjct: 20  KDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDHV 79

Query: 95  ITLADIVKDPVSRTPALVFEHVNNTDFK--QLYQTLTDYDIRFYMYEILKALDYCHSMGI 152
                  ++       +  +  N  D +  Q   T T         +IL++++  HS+G 
Sbjct: 80  CRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHSVGF 139

Query: 153 MHRDVKPHNVMID---HEHRKLRLIDWGLAEFY-------HPGQEYNVRVASRYFKGPEL 202
           +HRD+KP N  +      +RK  ++D+GLA  Y        P +       +  +     
Sbjct: 140 LHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRYASVNA 199

Query: 203 LVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAK 247
             + +M     D+WSL  ML      + P+    D  +Q+  I +
Sbjct: 200 HKNREM-GRHDDLWSLFYMLVEFAVGQLPWRKIKDK-EQVGMIKE 242


>2C47-A nrPDB
          Length = 313

 Score =  136 bits (342), Expect = 2e-32,   Method: Composition-based stats.
 Identities = 51/283 (18%), Positives = 106/283 (37%), Gaps = 26/283 (9%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK--KIKREIKILENLRGGPNII 95
           ++++ +K+G G + E+    N+  NE V +K L+P+K +  ++  E +  + L     + 
Sbjct: 5   NFRVGKKIGCGNFGELRLGKNLYTNEYVAIK-LEPIKSRAPQLHLEYRFYKQLSATEGVP 63

Query: 96  TLADIVKDPVSRTPALVFEHVN---NTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGI 152
            +      P  +  A+V E +       F    +T T   +     +++  ++Y H+  +
Sbjct: 64  QVYYF--GPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYVHTKSL 121

Query: 153 MHRDVKPHNVMIDHEH----RKLRLIDWGLAEFY--------HPGQEYNVRVASRYFKGP 200
           ++RDVKP N ++          + +ID+GLA+ Y         P +E+     +  +   
Sbjct: 122 IYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSI 181

Query: 201 ELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDK 260
              +  +      D+ +LG M    +    P+       D L    + +G       I+ 
Sbjct: 182 NTHLGKEQ-SRRDDLEALGHMFMYFLRGSLPWQGLK--ADTLKERYQKIGDTKRATPIEV 238

Query: 261 YNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDK 303
                       L    R     F    +   +     D  D+
Sbjct: 239 LCENFPEEMATYLRYVRRLD---FFEKPDYDYLRKLFTDLFDR 278


>2QLU-A nrPDB
          Length = 314

 Score =  135 bits (341), Expect = 2e-32,   Method: Composition-based stats.
 Identities = 57/306 (18%), Positives = 114/306 (37%), Gaps = 47/306 (15%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENL-RGGPNI 94
           +   QL+    RG++  V++A  +  N+ V VKI     K+  + E +I         N+
Sbjct: 14  RGSLQLLEIKARGRFGCVWKAQLM--NDFVAVKIFPLQDKQSWQSEREIFSTPGMKHENL 71

Query: 95  ITLADIVK--DPVSRTPALVFEHVNNTDFKQLYQT--LTDYDIRFYMYEILKALDYCHS- 149
           +      K    +     L+    +        +   +T  ++      + + L Y H  
Sbjct: 72  LQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHED 131

Query: 150 ----------MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ---EYNVRVASRY 196
                       I HRD K  NV++  +   + L D+GLA  + PG+   + + +V +R 
Sbjct: 132 VPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAV-LADFGLAVRFEPGKPPGDTHGQVGTRR 190

Query: 197 FKGPELLVDYQMYDY----SLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTE 252
           +  PE+L     +       +DM+++G +L  ++ R +                   G  
Sbjct: 191 YMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCK----------------AADGPV 234

Query: 253 DLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDF---LDKLLRYDH 309
           D Y    +  I   P   ++      K+       ++  L  P        +++   +D 
Sbjct: 235 DEYMLPFEEEIGQHPSLEELQEVVVHKK--MRPTIKDHWLKHPGLAQLCVTIEECWDHDA 292

Query: 310 QSRLTA 315
           ++RL+A
Sbjct: 293 EARLSA 298


>5X18-A nrPDB
          Length = 295

 Score =  135 bits (340), Expect = 3e-32,   Method: Composition-based stats.
 Identities = 46/263 (17%), Positives = 106/263 (40%), Gaps = 18/263 (6%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL-KPVKKKKIKREIKILENLRGGPNIIT 96
            Y++ +K+G G +  +FE  N+ N   V +K   +  +  +++ E K  + L G PNI  
Sbjct: 8   HYKIGKKIGEGSFGVLFEGTNMINGVPVAIKFEPRKTEAPQLRDEYKTYKILNGTPNIPY 67

Query: 97  LADIVKDPVSRTPALVFEHVNNTD-FKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHR 155
                ++ +     +     +  D F    +  +   +     +++  ++  H+  +++R
Sbjct: 68  AYYFGQEGLHNILVIDLLGPSLEDLFDWCGRKFSVKTVVQVAVQMITLIEDLHAHDLIYR 127

Query: 156 DVKPHNVMIDHEH----RKLRLIDWGLAEFYH--------PGQEYNVRVASRYFKGPELL 203
           D+KP N +I          + LID+G+A+ Y         P +E      +  +      
Sbjct: 128 DIKPDNFLIGRPGQPDANNIHLIDFGMAKQYRDPKTKQHIPYREKKSLSGTARYMSINTH 187

Query: 204 VDYQMYDYSLDMWSLGCMLASMIFRKEPF--FHGHDNYDQLVRIAKVLGTEDLYDYIDKY 261
           +  +      DM +LG +    +    P+      +N  +  +I +   + ++YD     
Sbjct: 188 LGREQ-SRRDDMEALGHVFFYFLRGHLPWQGLKAPNNKQKYEKIGEKKRSTNVYDLAQGL 246

Query: 262 NIELDPRFNDILGRHSRKRWERF 284
            ++   R+ +I+   S +    +
Sbjct: 247 PVQFG-RYLEIVRSLSFEECPDY 268


>5VC6-A nrPDB
          Length = 289

 Score =  134 bits (338), Expect = 5e-32,   Method: Composition-based stats.
 Identities = 46/314 (14%), Positives = 100/314 (31%), Gaps = 75/314 (23%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP-----VKKKKIKREIKILENLRGGP 92
           ++  + K+G G++  VF+ +   +     +K  K      V ++   RE+     L    
Sbjct: 12  EFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHS 71

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNTDF-------KQLYQTLTDYDIRFYMYEILKALD 145
           +++       +       +  E+ N            ++     + +++  + ++ + L 
Sbjct: 72  HVVRYFSAWAE--DDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLR 129

Query: 146 YCHSMGIMHRDVKPHNVMIDHEHRK------------------LRLIDWGLAEFYHPGQE 187
           Y HSM ++H D+KP N+ I                         ++ D G        Q 
Sbjct: 130 YIHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQ- 188

Query: 188 YNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAK 247
             V      F   E+L +   +    D+++L   +       EP     D + ++ +   
Sbjct: 189 --VEEGDSRFLANEVLQENYTHLPKADIFALALTV-VCAAGAEPLPRNGDQWHEIRQGR- 244

Query: 248 VLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRY 307
                              PR   +L                    S E  + L  ++  
Sbjct: 245 ------------------LPRIPQVL--------------------SQEFTELLKVMIHP 266

Query: 308 DHQSRLTAREAMEH 321
           D + R +A   ++H
Sbjct: 267 DPERRPSAMALVKH 280


>5J0A-A nrPDB
          Length = 300

 Score =  134 bits (337), Expect = 7e-32,   Method: Composition-based stats.
 Identities = 52/308 (16%), Positives = 101/308 (32%), Gaps = 50/308 (16%)

Query: 41  LVRKLGRGKYSE-VFEAINITNNEK---VVVKILKP--------VKKKKIKREIKILENL 88
            ++KLG G     V+               VK + P        V +K++  E KIL++L
Sbjct: 13  FMQKLGFGT-GVNVYLMKRSPRGLSHSPWAVKKINPICNDHYRSVYQKRLMDEAKILKSL 71

Query: 89  RGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ--------TLTDYDIRFYMYEI 140
              PNI+       +    +  L  E+        L +              I      +
Sbjct: 72  -HHPNIVGYR-AFTEANDGSLCLAMEYGGEKSLNDLIEERYKASQDPFPAAIILKVALNM 129

Query: 141 LKALDYCHS-MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNV----RVASR 195
            + L Y H    ++H D+K  NV+I  +   +++ D G++       E        + + 
Sbjct: 130 ARGLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMEVTDPEACYIGTE 189

Query: 196 YFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLY 255
            +K  E + +  +     D+++ G  L  M+    P                     +L 
Sbjct: 190 PWKPKEAVEENGVITDKADIFAFGLTLWEMMTLSIP-------------------HINLS 230

Query: 256 DYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTA 315
           +  D  +   D    D    ++       ++ E       + ++        D + R +A
Sbjct: 231 NDDDDEDKTFDESDFDDEAYYAALGTRPPINMEELDESYQKVIELFSVCTNEDPKDRPSA 290

Query: 316 R---EAME 320
               EA+E
Sbjct: 291 AHIVEALE 298


>2CMW-A nrPDB
          Length = 310

 Score =  133 bits (336), Expect = 9e-32,   Method: Composition-based stats.
 Identities = 55/282 (19%), Positives = 106/282 (37%), Gaps = 27/282 (9%)

Query: 40  QLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK--KIKREIKILENLRG-GPNIIT 96
           ++ +K+G G + E+    N+  NE V +K L+P+K +  ++  E +  + L   G  +  
Sbjct: 3   RVGKKIGCGNFGELRLGKNLYTNEYVAIK-LEPIKSRAPQLHLEYRFYKQLGSAGEGLPQ 61

Query: 97  LADIVKDPVSRTPALVFEHVN---NTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIM 153
           +      P  +  A+V E +       F    +T T   +     ++L  ++Y HS  ++
Sbjct: 62  VYYF--GPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYVHSKNLI 119

Query: 154 HRDVKPHNVMIDHEH----RKLRLIDWGLAEFY--------HPGQEYNVRVASRYFKGPE 201
           +RDVKP N +I  +       + +ID+GLA+ Y         P +E+     +  +    
Sbjct: 120 YRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSIN 179

Query: 202 LLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKY 261
             +  +      D+ +LG M    +    P+       D L    + +G       I+  
Sbjct: 180 THLGKEQ-SRRDDLEALGHMFMYFLRGSLPWQGLK--ADTLKERYQKIGDTKRNTPIEAL 236

Query: 262 NIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDK 303
                      L    R     F    +   +     D  +K
Sbjct: 237 CENFPEEMATYLRYVRRLD---FFEKPDYEYLRTLFTDLFEK 275


>4NT4-A nrPDB
          Length = 312

 Score =  133 bits (335), Expect = 1e-31,   Method: Composition-based stats.
 Identities = 56/287 (19%), Positives = 111/287 (38%), Gaps = 28/287 (9%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK--KIKREIKILENLRGG---- 91
           ++++ +K+G G + E+    N+ NNE V +K ++P+K K  ++  E +  + L       
Sbjct: 13  NFRVGKKIGCGNFGELRLGKNLYNNEHVAIK-MEPMKSKAPQLHLEYRFYKLLGSHADNA 71

Query: 92  PNIITLADIVKDPVSRTPALVFEHVNNTD---FKQLYQTLTDYDIRFYMYEILKALDYCH 148
           P+ I     +     R  A+V E +  +    F    +  +   +     ++L  ++Y H
Sbjct: 72  PDGIPRIYHLGTCGGRYNAMVLELLGLSLEDLFNICARKFSLKTVLMIAKQLLHRIEYVH 131

Query: 149 SMGIMHRDVKPHNVMI----DHEHRKLRLIDWGLAEFY--------HPGQEYNVRVASRY 196
           S  +++RDVKP N +I        + + +ID+GLA+ Y         P +E+     +  
Sbjct: 132 SRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRHIPYREHKSLTGTAR 191

Query: 197 FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYD 256
           +      +  +      D+ +LG M    +    P+       D L    + +G      
Sbjct: 192 YMSINTHMGREQ-SRRDDLEALGHMFMYFLRGSLPWQGLK--ADTLKERYQKIGDTKRAT 248

Query: 257 YIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDK 303
            I+         F   L    R     F  + +   +     D  D+
Sbjct: 249 PIEVLCDGHPEEFATYLRYVRRLD---FFETPDYDFLRRLFQDLFDR 292


>5VDK-A nrPDB
          Length = 297

 Score =  131 bits (330), Expect = 5e-31,   Method: Composition-based stats.
 Identities = 47/326 (14%), Positives = 102/326 (31%), Gaps = 79/326 (24%)

Query: 25  DYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKI-LKP----VKKKKIK 79
           ++ S  +    + ++  V K+G G++  V++ I   +     +K  +K       +    
Sbjct: 3   EFGSTNMASRYEKEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSAL 62

Query: 80  REIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY-------QTLTDYD 132
            E+     L   P+++       +       +  E+ N    +              +  
Sbjct: 63  HEVYAHAVLGHHPHVVRYYSSWAE--DDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPK 120

Query: 133 IRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHE----------------------HRK 170
           ++  + +I   L+Y H+  ++H D+KP N+ I H+                      +  
Sbjct: 121 LKDILLQISLGLNYIHNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVM 180

Query: 171 LRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKE 230
            ++ D G A   +   +  V      F   E+L +   +    D+++LG           
Sbjct: 181 YKIGDLGHATSIN---KPKVEEGDSRFLANEILQEDYRHLPKADIFALGLT--------- 228

Query: 231 PFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQ 290
                         IA   G E L      ++      F D+                  
Sbjct: 229 --------------IAVAAGAESLPTNGAAWHHIRKGNFPDVPQE--------------- 259

Query: 291 HLVSPEALDFLDKLLRYDHQSRLTAR 316
             +S      L  +++ D + R +A 
Sbjct: 260 --LSESFSSLLKNMIQPDAEQRPSAA 283


>2PZI-A nrPDB
          Length = 681

 Score =  131 bits (329), Expect = 6e-31,   Method: Composition-based stats.
 Identities = 59/246 (23%), Positives = 108/246 (43%), Gaps = 31/246 (12%)

Query: 38  DYQLVRKLGRGKYSEVFEAINIT-NNEKVVVKIL----------KPVKKKKIKREIKILE 86
            Y++   +  G    ++ A++   N   VV+K L            + +++   E+    
Sbjct: 81  QYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAERQFLAEVV--- 137

Query: 87  NLRGGPNIITLADIVKDPVSRTP---ALVFEHVNNTDFKQ-LYQTLTDYDIRFYMYEILK 142
                P+I+ + + V+           +V E+V     K+   Q L   +   Y+ EIL 
Sbjct: 138 ----HPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSLKRSKGQKLPVAEAIAYLLEILP 193

Query: 143 ALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPEL 202
           AL Y HS+G+++ D+KP N+M+  E  +L+LID G     +    +     +  F+ PE+
Sbjct: 194 ALSYLHSIGLVYNDLKPENIMLTEE--QLKLIDLGAVSRINS---FGYLYGTPGFQAPEI 248

Query: 203 LVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYN 262
           +        + D++++G  LA++     P  +G    D L     VL T D Y  + +  
Sbjct: 249 VRTGP--TVATDIYTVGRTLAAL-TLDLPTRNGR-YVDGLPEDDPVLKTYDSYGRLLRRA 304

Query: 263 IELDPR 268
           I+ DPR
Sbjct: 305 IDPDPR 310


>4Y12-A nrPDB
          Length = 375

 Score =  130 bits (328), Expect = 7e-31,   Method: Composition-based stats.
 Identities = 59/246 (23%), Positives = 108/246 (43%), Gaps = 31/246 (12%)

Query: 38  DYQLVRKLGRGKYSEVFEAINIT-NNEKVVVKIL----------KPVKKKKIKREIKILE 86
            Y++   +  G    ++ A++   N   VV+K L            + +++   E+    
Sbjct: 120 QYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAERQFLAEVV--- 176

Query: 87  NLRGGPNIITLADIVKDPVSRTP---ALVFEHVNNTDFKQ-LYQTLTDYDIRFYMYEILK 142
                P+I+ + + V+           +V E+V     K+   Q L   +   Y+ EIL 
Sbjct: 177 ----HPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSLKRSKGQKLPVAEAIAYLLEILP 232

Query: 143 ALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPEL 202
           AL Y HS+G+++ D+KP N+M+  E  +L+LID G     +    +     +  F+ PE+
Sbjct: 233 ALSYLHSIGLVYNDLKPENIMLTEE--QLKLIDLGAVSRINS---FGYLYGTPGFQAPEI 287

Query: 203 LVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYN 262
           +        + D++++G  LA++     P  +G    D L     VL T D Y  + +  
Sbjct: 288 VRTGP--TVATDIYTVGRTLAAL-TLDLPTRNGR-YVDGLPEDDPVLKTYDSYGRLLRRA 343

Query: 263 IELDPR 268
           I+ DPR
Sbjct: 344 IDPDPR 349


>3HNG-A nrPDB
          Length = 360

 Score =  129 bits (324), Expect = 3e-30,   Method: Composition-based stats.
 Identities = 32/166 (19%), Positives = 77/166 (46%), Gaps = 16/166 (9%)

Query: 124 LYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH 183
             + +T  D+  Y +++ + +++  S   +HRD+   N+++  E+  +++ D+GLA   +
Sbjct: 192 YKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILL-SENNVVKICDFGLARDIY 250

Query: 184 PGQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIF-RKEPFFHGHDNY 239
              +Y  +  +R    +  PE + D ++Y    D+WS G +L  +      P+     + 
Sbjct: 251 KNPDYVRKGDTRLPLKWMAPESIFD-KIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDE 309

Query: 240 DQLVRIAKVL-------GTEDLYDYIDKY---NIELDPRFNDILGR 275
           D   R+ + +        T ++Y  +      + +  PRF +++ +
Sbjct: 310 DFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEK 355



 Score = 82.0 bits (201), Expect = 4e-16,   Method: Composition-based stats.
 Identities = 24/115 (20%), Positives = 47/115 (40%), Gaps = 11/115 (9%)

Query: 22  EYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEA-----INITNNEKVVVKILKP---- 72
           E   Y++   E+  ++  +L + LGRG + +V +A             V VK+LK     
Sbjct: 13  ERLPYDASKWEFA-RERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATA 71

Query: 73  VKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT 127
            + K +  E+KIL ++    N++ L             +V E+    +     ++
Sbjct: 72  SEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIV-EYCKYGNLSNYLKS 125


>4RT7-A nrPDB
          Length = 415

 Score =  128 bits (322), Expect = 4e-30,   Method: Composition-based stats.
 Identities = 35/159 (22%), Positives = 68/159 (42%), Gaps = 11/159 (6%)

Query: 80  REIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYE 139
           RE++I         I  L     +       + +E+    + ++    LT  D+  + Y+
Sbjct: 198 REVQIH---PDSDQISGLHG---NSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQ 251

Query: 140 ILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY--- 196
           + K +++      +HRD+   NV++ H  + +++ D+GLA        Y VR  +R    
Sbjct: 252 VAKGMEFLEFKSCVHRDLAARNVLVTH-GKVVKICDFGLARDIMSDSNYVVRGNARLPVK 310

Query: 197 FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHG 235
           +  PE L +  +Y    D+WS G +L  +       + G
Sbjct: 311 WMAPESLFE-GIYTIKSDVWSYGILLWEIFSLGVNPYPG 348



 Score = 96.2 bits (238), Expect = 2e-20,   Method: Composition-based stats.
 Identities = 25/135 (18%), Positives = 52/135 (38%), Gaps = 19/135 (14%)

Query: 11  VYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINI---TNNE--KV 65
            Y D   +     W++         +++ +  + LG G + +V  A            +V
Sbjct: 47  FYVDFREYEYDLKWEFP--------RENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQV 98

Query: 66  VVKILKPV----KKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDF 121
            VK+LK      +++ +  E+K++  L    NI+ L       +S    L+FE+    D 
Sbjct: 99  AVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACT--LSGPIYLIFEYCCYGDL 156

Query: 122 KQLYQTLTDYDIRFY 136
               ++  +   R +
Sbjct: 157 LNYLRSKREKFHRTW 171


>3VHK-A nrPDB
          Length = 368

 Score =  126 bits (317), Expect = 1e-29,   Method: Composition-based stats.
 Identities = 36/197 (18%), Positives = 74/197 (37%), Gaps = 40/197 (20%)

Query: 128 LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE 187
           LT   +  Y +++ K +++  S   +HRD+   N+++  ++  +++ D+GLA   +   +
Sbjct: 197 LTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKN-VVKICDFGLARDIYKDPD 255

Query: 188 YNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVR 244
           Y  +  +R    +  PE + D ++Y    D+WS G +L  +       + G         
Sbjct: 256 YVRKGDARLPLKWMAPETIFD-RVYTIQSDVWSFGVLLWEIFSLGASPYPG--------- 305

Query: 245 IAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKL 304
                             +++D  F   L   +R R   +   E    +           
Sbjct: 306 ------------------VKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLD--------C 339

Query: 305 LRYDHQSRLTAREAMEH 321
              +   R T  E +EH
Sbjct: 340 WHGEPSQRPTFSELVEH 356



 Score = 83.1 bits (204), Expect = 2e-16,   Method: Composition-based stats.
 Identities = 29/126 (23%), Positives = 54/126 (42%), Gaps = 14/126 (11%)

Query: 14  DVNTHRPREYWD---YESHVVEWGNQDDYQLVRKLGRGKYSEVFEA----INIT-NNEKV 65
           D +     E+ +   Y++   E+  +D  +L + LGRG + +V EA    I+ T     V
Sbjct: 4   DPDELPLDEHCERLPYDASKWEF-PRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTV 62

Query: 66  VVKILKP----VKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDF 121
            VK+LK      + + +  E+KIL ++    N++ L      P      +V E     + 
Sbjct: 63  AVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIV-EFCKFGNL 121

Query: 122 KQLYQT 127
               ++
Sbjct: 122 STYLRS 127


>1CSN-A nrPDB
          Length = 298

 Score =  123 bits (310), Expect = 8e-29,   Method: Composition-based stats.
 Identities = 41/244 (16%), Positives = 96/244 (39%), Gaps = 17/244 (6%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL-KPVKKKKIKREIKILENLRGGPNIIT 96
            Y++ R++G G +  +FE  N+ NN++V +K   +     +++ E +  + L G   I  
Sbjct: 11  HYKVGRRIGEGSFGVIFEGTNLLNNQQVAIKFEPRRSDAPQLRDEYRTYKLLAGCTGIPN 70

Query: 97  LADIVKDPVSRTPALVFEHVNNTDFKQLY-QTLTDYDIRFYMYEILKALDYCHSMGIMHR 155
           +    ++ +     +     +  D   L  +  +   +     ++L  +   H   +++R
Sbjct: 71  VYYFGQEGLHNVLVIDLLGPSLEDLLDLCGRKFSVKTVAMAAKQMLARVQSIHEKSLVYR 130

Query: 156 DVKPHNVMIDHEHRK----LRLIDWGLAEFYH--------PGQEYNVRVASRYFKGPELL 203
           D+KP N +I   + K    + ++D+G+ +FY         P +E      +  +      
Sbjct: 131 DIKPDNFLIGRPNSKNANMIYVVDFGMVKFYRDPVTKQHIPYREKKNLSGTARYMSINTH 190

Query: 204 VDYQMYDYSLDMWSLGCMLASMIFRKEPF--FHGHDNYDQLVRIAKVLGTEDLYDYIDKY 261
           +  +      D+ +LG +    +    P+       N  +  RI +   +  L +    +
Sbjct: 191 LGREQ-SRRDDLEALGHVFMYFLRGSLPWQGLKAATNKQKYERIGEKKQSTPLRELCAGF 249

Query: 262 NIEL 265
             E 
Sbjct: 250 PEEF 253


>5M07-A nrPDB
          Length = 276

 Score =  122 bits (305), Expect = 3e-28,   Method: Composition-based stats.
 Identities = 45/217 (20%), Positives = 84/217 (38%), Gaps = 31/217 (14%)

Query: 39  YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK------KKKIKREIKILENLRGGP 92
           Y +VR LG     EV+   +        +K+L P        +++ +RE ++   L   P
Sbjct: 32  YTVVRMLGASAMGEVYLVQHPGFPGWQALKVLSPAMAADDEFRRRFQRETEVAARLFH-P 90

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ-----TLTDYDIRFYMYEILKALDYC 147
           +I+ + D  +        +  ++V+  D  Q         L   ++   +  +  ALDY 
Sbjct: 91  HILEVHD--RGEFDGQLWIAMDYVDGIDATQHMADRFPAVLPVGEVLAIVTAVAGALDYA 148

Query: 148 HSMGIMHRDVKPHNVMIDHE---HRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLV 204
           H  G++HRDV P NV++  +    +++ L D+G+A                 +  PEL  
Sbjct: 149 HQRGLLHRDVNPANVVLTSQSAGDQRILLADFGIASQ-------------PSYPAPELSA 195

Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQ 241
              +   + D ++L      +     P    H    Q
Sbjct: 196 GADVDGRA-DQYALALTAIHLFAGAPPVDRSHTGPLQ 231


>4XHH-A nrPDB
          Length = 403

 Score =  120 bits (302), Expect = 8e-28,   Method: Composition-based stats.
 Identities = 44/283 (15%), Positives = 102/283 (36%), Gaps = 26/283 (9%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK-PVKKKKIKREIKILENLRGGPNIIT 96
            +++ RK+G G + +++   N+ + E+V +++     +  ++  E ++ + L GG  I  
Sbjct: 8   KFRIGRKIGSGSFGDIYHGTNLISGEEVAIRLESIRSRHPQLDYESRVYKYLSGGVGIPF 67

Query: 97  LADIVKDPVSRTPALVFEHVN---NTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIM 153
           +    ++      A+V + +       F   ++  +   +     +++  + Y H    +
Sbjct: 68  IRWFGRE--GEYNAMVIDLLGPSLEDLFNYCHRKFSFKTVIMLALQMICRVQYIHGRSFI 125

Query: 154 HRDVKPHNVM--IDHEHRKLRLIDWGLAEFYHPGQEY--------NVRVASRYFKGPELL 203
           HRD+KP N +  +      + +ID+GL++ Y     +             +  +      
Sbjct: 126 HRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTARYASVNTH 185

Query: 204 VDYQMYDYSLDMWSLGCMLASMIFRKEPF--FHGHDNYDQLVRIAKVLGTEDLYDYIDKY 261
           +  +      D+ SLG ML        P+          +  RI +      +       
Sbjct: 186 LGIEQ-SRRDDLESLGYMLIYFCKGSLPWQGLKATTKKQKYDRILEKKLCISVETLCAGL 244

Query: 262 NIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKL 304
            +E     N         R  +F    +   ++    D   KL
Sbjct: 245 PLEFSEYMN-------YCRNLKFDERPDYLYLARLFKDLSIKL 280


>6BFN-A nrPDB
          Length = 342

 Score =  120 bits (300), Expect = 2e-27,   Method: Composition-based stats.
 Identities = 42/212 (19%), Positives = 74/212 (34%), Gaps = 33/212 (15%)

Query: 44  KLGRGKYSEVFEAINITNNEKVVVKILKPVK-------KKKIKREIKILENLRGGPNIIT 96
           K+G G +  V+ A+         VK LK          K+    E++ L   R  PNI+ 
Sbjct: 29  KIGEGGFGCVYRAVMRNT--VYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRH-PNIVD 85

Query: 97  LADIVKDPVSRTPALVFEHVNNTDFKQLYQ-------TLTDYDIRFYMYEILKALDYCH- 148
            A       +    LV+  + N   +            L+       +    +A+ + H 
Sbjct: 86  FAGYC--AQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQ 143

Query: 149 -SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF----------YHPGQEYNVRVASRYF 197
            S  ++H D+K  NV++D E    +L D+GLA F                      +  +
Sbjct: 144 DSPSLIHGDIKSSNVLLD-ERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAY 202

Query: 198 KGPELLVDYQMYDYSLDMWSLGCMLASMIFRK 229
             PE  +         D +S G ++   +  +
Sbjct: 203 L-PEEYIKTGRLAVDTDTFSFGVVVLETLAGQ 233


>4XHL-A nrPDB
          Length = 394

 Score =  117 bits (294), Expect = 7e-27,   Method: Composition-based stats.
 Identities = 34/209 (16%), Positives = 83/209 (39%), Gaps = 17/209 (8%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK-PVKKKKIKREIKILENLRGGPNIIT 96
            +++ RK+G G + +++   N+ + E+V +++     +  ++  E ++   L GG  I  
Sbjct: 8   KFRIGRKIGSGSFGDIYHGTNLISGEEVAIRLESIRSRHPQLDYESRVYRYLSGGVGIPF 67

Query: 97  LADIVKDPVSRTPALVFEHVN---NTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIM 153
           +    ++      A+V + +       F   ++  +   +     ++   + Y H    +
Sbjct: 68  IRWFGRE--GEYNAMVIDLLGPSLEDLFNYCHRRFSFKTVIMLALQMFCRIQYIHGRSFI 125

Query: 154 HRDVKPHNVM--IDHEHRKLRLIDWGLAEFYHPGQEY--------NVRVASRYFKGPELL 203
           HRD+KP N +  +      + +ID+GL++ Y     +             +  +      
Sbjct: 126 HRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTARYASVNTH 185

Query: 204 VDYQMYDYSLDMWSLGCMLASMIFRKEPF 232
           +  +      D+ SLG +L        P+
Sbjct: 186 LGIEQ-SRRDDLESLGYVLIYFCKGSLPW 213


>4MWI-A nrPDB
          Length = 294

 Score =  112 bits (280), Expect = 3e-25,   Method: Composition-based stats.
 Identities = 44/276 (15%), Positives = 96/276 (34%), Gaps = 58/276 (21%)

Query: 65  VVVKILKPVK-------KKKIKREIKILENLRGGPNIITLADIVKDPVSRTPA--LVFEH 115
           V +K+ K ++       ++   +EIK ++     PNI+ +  I  D     P   +V E+
Sbjct: 50  VAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFE-SPNILRIFGICIDETVTPPQFSIVMEY 108

Query: 116 VNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCHSMGI--MHRDVKPHNVMIDHEHRK 170
                 ++L    + LT       +    + L   H      +H  ++  N ++  +  +
Sbjct: 109 CELGTLRELLDREKDLTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVT-QGYQ 167

Query: 171 LRLIDWGLAEF-----YHPGQEYNVRVASRYFKGPELLVD-YQMYDYSLDMWSLGCMLAS 224
           ++L  + L +          +E   RV S  +  P+ L D +  YD   +++S G +L  
Sbjct: 168 VKLAGFELRKTQTSMSLGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWE 227

Query: 225 MIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERF 284
           +     PF   +       +I K++  +   + +                          
Sbjct: 228 IATGDIPFQGCNSE-----KIRKLVAVKRQQEPLG------------------------- 257

Query: 285 VHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAME 320
                      E  + +D+   +D   R +  E ++
Sbjct: 258 ------EDCPSELREIIDECRAHDPSVRPSVDEILK 287


>5UV4-A nrPDB
          Length = 311

 Score =  112 bits (279), Expect = 4e-25,   Method: Composition-based stats.
 Identities = 54/280 (19%), Positives = 105/280 (37%), Gaps = 40/280 (14%)

Query: 43  RKLGRGKYSEVFEAINITNNEKVVVKILKP---VKKKKIKREIKILENLRGGPNIITLAD 99
             +GR  +   ++A  + N   + VK LK      KK+  REIK L ++R  PN++ L  
Sbjct: 31  EIIGRSCHGTSYKAT-LDNGYMLTVKWLKEGFAKSKKEFSREIKKLGSVRH-PNLVPLRG 88

Query: 100 IVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDI--------RFYMYEILKALDYCHSMG 151
               P      ++ ++ + T          + ++             +I + LDY H+  
Sbjct: 89  YYWGPKEHERIMISDYADATSLSTYLSEFDERNLPPLSAGQRLNIAIDIARCLDYLHNER 148

Query: 152 IM-HRDVKPHNVMIDHEHRKLRLIDWGLAEFYHP--GQEYNVRVASRYFKGPELLVDYQM 208
           ++ H ++K  NV+I +      + D+ L     P    E  +   +  +  PE     + 
Sbjct: 149 VIPHGNIKSSNVLIQNSTPSALVTDYSLHRLMTPIGMAEQVLNAGALGYSPPEFSSTSKP 208

Query: 209 Y-DYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDP 267
                 D+++ G +L  ++  K               I    G  DL D++   ++E   
Sbjct: 209 CPSLKSDVYAFGVILLELLTGKI----------AGEIICMNDGVVDLTDWVRMLDLEER- 257

Query: 268 RFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRY 307
                      + ++R +        +P+ALD    +LR 
Sbjct: 258 ---------VSECYDRHITGVESSEGAPQALD---GMLRI 285


>4BTF-A nrPDB
          Length = 469

 Score =  106 bits (264), Expect = 2e-23,   Method: Composition-based stats.
 Identities = 41/253 (16%), Positives = 93/253 (36%), Gaps = 25/253 (9%)

Query: 65  VVVKILKPVKKK-------KIKREIKILENLRGGPNIITLADIVKDPVSRTP--ALVFEH 115
           V +K+    + +           EIK ++     PNI+ +  I  D   + P  ++V E+
Sbjct: 221 VTIKVFNNPQAESVGIVRFTFNDEIKTMKKF-DSPNILRIFGICIDQTVKPPEFSIVMEY 279

Query: 116 VNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLR 172
                 ++L    + LT       +    + L   H    +HR++   + ++     +++
Sbjct: 280 CELGTLRELLDREKDLTMSVRSLLVLRAARGLYRLHHSETLHRNISSSSFLV-AGGYQVK 338

Query: 173 LIDWGLAEFYHPGQEYN-----VRVASRYFKGPELLVD-YQMYDYSLDMWSLGCMLASMI 226
           L  + L++  +            R +S  +  PE L + + +YD   +++S G +L  + 
Sbjct: 339 LAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDIKAEIYSFGIVLWEIA 398

Query: 227 FRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVH 286
             K PF           +I +++  +   + + +   EL     +    H   +      
Sbjct: 399 TGKIPFEGCDS-----KKIRELVAEDKKQEPVGQDCPELLREIINECRAHEPSQRPSVDG 453

Query: 287 SENQHLVSPEALD 299
              +     E+ D
Sbjct: 454 ILERLSAVEESTD 466


>4M69-B nrPDB
          Length = 283

 Score =  105 bits (263), Expect = 2e-23,   Method: Composition-based stats.
 Identities = 41/253 (16%), Positives = 93/253 (36%), Gaps = 25/253 (9%)

Query: 65  VVVKILKPVKKK-------KIKREIKILENLRGGPNIITLADIVKDPVSRTP--ALVFEH 115
           V +K+    + +           EIK ++     PNI+ +  I  D   + P  ++V E+
Sbjct: 35  VTIKVFNNPQAESVGIVRFTFNDEIKTMKKF-DSPNILRIFGICIDQTVKPPEFSIVMEY 93

Query: 116 VNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLR 172
                 ++L    + LT       +    + L   H    +HR++   + ++     +++
Sbjct: 94  CELGTLRELLDREKDLTMSVRSLLVLRAARGLYRLHHSETLHRNISSSSFLV-AGGYQVK 152

Query: 173 LIDWGLAEFYHPGQEYN-----VRVASRYFKGPELLVD-YQMYDYSLDMWSLGCMLASMI 226
           L  + L++  +            R +S  +  PE L + + +YD   +++S G +L  + 
Sbjct: 153 LAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDIKAEIYSFGIVLWEIA 212

Query: 227 FRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVH 286
             K PF           +I +++  +   + + +   EL     +    H   +      
Sbjct: 213 TGKIPFEGCDS-----KKIRELVAEDKKQEPVGQDCPELLREIINECRAHEPSQRPSVDG 267

Query: 287 SENQHLVSPEALD 299
              +     E+ D
Sbjct: 268 ILERLSAVEESTD 280


>4JRN-A nrPDB
          Length = 372

 Score =  104 bits (259), Expect = 7e-23,   Method: Composition-based stats.
 Identities = 51/319 (15%), Positives = 94/319 (29%), Gaps = 90/319 (28%)

Query: 44  KLGRGKYSEVFEAINITNNEKVVVKILKPVKKK------KIKREIKILENLRGGP----- 92
            LG G ++ V+EA ++  NE++ VK+    K+        ++RE     N          
Sbjct: 75  PLGSGGFATVYEATDVETNEELAVKVFMSEKEPTDETMLDLQRESSCYRNFSLAKTAKDA 134

Query: 93  ----------NIITLAD------IVKDPVSRTP---ALVFEHVN----------NTDFKQ 123
                     +++ L        +V    +R      L+                 D   
Sbjct: 135 QESCRFMVPSDVVMLEGQPASTEVVIGLTTRWVPNYFLLMMRAEADMSKVISWVFGDASV 194

Query: 124 LYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH 183
                      +   + +K +    + GI+H D+KP N ++  + R L L D+G    Y 
Sbjct: 195 NKSEFGLVVRMYLSSQAIKLVANVQAQGIVHTDIKPANFLLLKDGR-LFLGDFG---TYR 250

Query: 184 PGQEYNVRVASRYFKGPELLVDYQM--YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQ 241
                   + +  ++ PE         Y +  D W LG  L  +  ++ P          
Sbjct: 251 INNSVGRAIGTPGYEPPERPFQATGITYTFPTDAWQLGITLYCIWCKERP---------- 300

Query: 242 LVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFL 301
                                                     ++H  +         D +
Sbjct: 301 ----------------------------------TPADGIWDYLHFADCPSTPELVQDLI 326

Query: 302 DKLLRYDHQSRLTAREAME 320
             LL  D Q R+   +A+E
Sbjct: 327 RSLLNRDPQKRMLPLQALE 345


>4L00-A nrPDB
          Length = 304

 Score =  103 bits (258), Expect = 1e-22,   Method: Composition-based stats.
 Identities = 47/288 (16%), Positives = 87/288 (30%), Gaps = 64/288 (22%)

Query: 64  KVVVKILKPVKKKKIKR--EIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDF 121
           KV++K+L P  +       E   +       +I+ L  +    V     +V E V     
Sbjct: 62  KVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENI--MVEEFVEGGPL 119

Query: 122 KQLYQT----LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRK------L 171
                     LT         ++  AL Y     ++H +V   N+++  E         +
Sbjct: 120 DLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFI 179

Query: 172 RLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEP 231
           +L D G+       QE   R+    +  PE + D +    + D WS G  L  + +  E 
Sbjct: 180 KLSDPGIPITVLSRQECIERI---PWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEI 236

Query: 232 FFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQH 291
                   +                           RF +   R      +         
Sbjct: 237 PLKDKTLIE-------------------------KERFYESRCRPVTPSCK--------- 262

Query: 292 LVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSM 339
               E  D + + + YD   R         P+F  +++D  ++   + 
Sbjct: 263 ----ELADLMTRCMNYDPNQR---------PFFRAIMRDINKLEEQNP 297


>5USZ-A nrPDB
          Length = 289

 Score =  103 bits (257), Expect = 1e-22,   Method: Composition-based stats.
 Identities = 37/267 (13%), Positives = 90/267 (33%), Gaps = 35/267 (13%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNE-------KVVVKILKPVKK---KKIKREIKIL 85
            +D      LG+G ++++F+ +     +       +V++K+L    +   +       ++
Sbjct: 7   NEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMM 66

Query: 86  ENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----LTDYDIRFYMYEIL 141
             L    +++    +          LV E V         +     +          ++ 
Sbjct: 67  SKLSH-KHLVLNYGVC--VCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLA 123

Query: 142 KALDYCHSMGIMHRDVKPHNVMIDHEHRK-------LRLIDWGLAEFYHPGQEYNVRVAS 194
            A+ +     ++H +V   N+++  E  +       ++L D G++    P      R+  
Sbjct: 124 AAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERI-- 181

Query: 195 RYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTE-- 252
             +  PE + + +  + + D WS G  L  +    +      D+  +L            
Sbjct: 182 -PWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAP 240

Query: 253 ------DLYDYIDKYNIELDPRFNDIL 273
                 +L +    Y  +  P F  I+
Sbjct: 241 KAAELANLINNCMDYEPDHRPSFRAII 267


>5X1R-A nrPDB
          Length = 302

 Score =  103 bits (256), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 37/227 (16%), Positives = 81/227 (35%), Gaps = 35/227 (15%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK------------------- 77
           +++++   +G G +  V+ A +      + +K   P    K                   
Sbjct: 21  NEFEIQEAIGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAKRNDDLSIGLRGERFGKTFQ 80

Query: 78  -----IKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY----QTL 128
                  +E ++L      P ++ +    ++  + T  +  +  + T  K L     + +
Sbjct: 81  AGLNSFIQEARLLARFSH-PGLLHVLRFWEE--NGTAYMGTQFYSGTTLKNLQAQQPEKI 137

Query: 129 TDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE-FYHPGQE 187
            +  IR  +  +  A++  H  G +HRD+   N+ I      + L+D+G A        +
Sbjct: 138 DEAWIRRLLPPLFSAINTIHQEGYLHRDISLDNIQIQESQLPV-LLDFGSARKEIGNLSD 196

Query: 188 YNVRVASRYFKGPELLVDY--QMYDYSLDMWSLGCMLASMIFRKEPF 232
               V    F   E   +          D+++LG +L ++I    P 
Sbjct: 197 ETEIVLKPGFAPIEQYTENSDGEQGPWTDIYALGAVLHTLIVGSPPP 243


>5OAT-A nrPDB
          Length = 411

 Score = 96.6 bits (239), Expect = 2e-20,   Method: Composition-based stats.
 Identities = 47/344 (13%), Positives = 101/344 (29%), Gaps = 103/344 (29%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEK-----VVVK-------------ILKPVKKKKI 78
           +D  L + + +G    V+ A    +          +K             ILK + ++ +
Sbjct: 11  NDLSLGKPIAKGTNGVVYSAKVKDDETDDNKYPFALKMMFNYDIQENSMEILKAMYRETV 70

Query: 79  KR------------EIKILENLRG---GPNIITLADIVKDPV---------------SRT 108
                         EI++    +     PNI+ +  +  D                 + +
Sbjct: 71  PARMYYSNHDLNNWEIELANRRKHLPPHPNIVAIFSVFTDLYPAALPPRLHPEGEGRNMS 130

Query: 109 PALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDH-- 166
             L+ +  +      L    +       + ++L+ + +  + GI HRD+K  N+++D   
Sbjct: 131 LFLLMKRYDCNLQSFLSTAPSTRTSLLLLAQLLEGVAHMTAHGIAHRDLKSDNLLLDTSE 190

Query: 167 -EHRKLRLIDWGLAEFYHPG-------QEYNVRVASRYFKGPELLVDYQM------YDYS 212
            E   L + D+G                    +  +     PE++           Y   
Sbjct: 191 PESPILVISDFGCCLADKTNGLSLPYTSYEMDKGGNTALMAPEIICQKPGTFSVLNYS-K 249

Query: 213 LDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDI 272
            D+W++G +   +     PF+                G   L ++   Y     P+  D 
Sbjct: 250 ADLWAVGAIAYEIFNCHNPFY----------------GPSRLKNF--NYKEGDLPKLPDE 291

Query: 273 LGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAR 316
           +    +                      +  LL+ +   RL   
Sbjct: 292 VPTVIQA--------------------LVANLLKRNPNKRLDPE 315


>6EQI-C nrPDB
          Length = 433

 Score = 95.8 bits (237), Expect = 3e-20,   Method: Composition-based stats.
 Identities = 52/328 (15%), Positives = 112/328 (34%), Gaps = 83/328 (25%)

Query: 31  VEWGNQDDYQLVRKLGRGKYSEVFEAI--NITNNE---KVVVKILKPVKKK--------K 77
           ++  N D+  L   + +G  + V+ A   N+ +N+   ++ VK++     +         
Sbjct: 9   LQAANLDELDLGEPIAKGCNAVVYSAKLKNVQSNKLAHQLAVKMMFNYDVESNSTAILKA 68

Query: 78  IKRE------------------IKILE-NLRGGPNIITLADIVKDPV------------- 105
           + RE                  I   +  L   PNI+ +  +  D +             
Sbjct: 69  MYRETVPAMSYFFNQNLFNIENISDFKIRLPPHPNIVRMYSVFADRIPDLQCNKQLYPEA 128

Query: 106 ------------SRTPALVFEHVNNTDFKQLYQTLTD--YDIRFYMYEILKALDYCHSMG 151
                       + +  LV +  +    K+  +  T         + ++L+A+ + +   
Sbjct: 129 LPPRINPEGSGRNMSLFLVMKRYD-CTLKEYLRDKTPNMRSSILLLSQLLEAVAHMNIHN 187

Query: 152 IMHRDVKPHNVMIDHEHR----KLRLIDWGLAEFYHPG-------QEYNVRVASRYFKGP 200
           I HRD+K  N+++D         + + D+G                E   +  +R    P
Sbjct: 188 ISHRDLKSDNILVDLSEGDAYPTIVITDFGCCLCDKQNGLVIPYRSEDQDKGGNRALMAP 247

Query: 201 ELLVDYQM------YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDL 254
           E+            Y    D+W++G +   +     PF+        +  ++K    EDL
Sbjct: 248 EIANAKPGTFSWLNY-KKSDLWAVGAIAYEIFNIDNPFYD-----KTMKLLSKSYKEEDL 301

Query: 255 YDYIDKYNIELDPRFNDILGRHSRKRWE 282
            +  D     +    +++L R + KR +
Sbjct: 302 PELPDTIPFIIRNLVSNMLSRSTNKRLD 329


>3REP-A nrPDB
          Length = 271

 Score = 92.4 bits (228), Expect = 3e-19,   Method: Composition-based stats.
 Identities = 39/210 (18%), Positives = 80/210 (38%), Gaps = 24/210 (11%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK-----PVKKKKIKREIKILENLRGGP 92
               + KL      E+++         +VVK+LK       K +    E   L  +   P
Sbjct: 11  QLNFLTKLNENHSGELWKGRWQ--GNDIVVKVLKVRDWSTRKSRDFNEECPRLR-IFSHP 67

Query: 93  NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ-----TLTDYDIRFYMYEILKALDYC 147
           N++ +    + P +  P L+   +       +        +       +  ++ + + + 
Sbjct: 68  NVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFL 127

Query: 148 HSMG-IMHR-DVKPHNVMIDHE-HRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLV 204
           H++  ++ R  +   +VMID +   ++ + D   + F  PG+ Y     +  +  PE L 
Sbjct: 128 HTLEPLIPRHALNSRSVMIDEDMTARISMADVKFS-FQSPGRMY-----APAWVAPEALQ 181

Query: 205 DYQMYD--YSLDMWSLGCMLASMIFRKEPF 232
                    S DMWS   +L  ++ R+ PF
Sbjct: 182 KKPEDTNRRSADMWSFAVLLWELVTREVPF 211


>5CLR-A nrPDB
          Length = 451

 Score = 90.1 bits (222), Expect = 2e-18,   Method: Composition-based stats.
 Identities = 31/192 (16%), Positives = 70/192 (36%), Gaps = 23/192 (11%)

Query: 54  FEAINITNNEKVVVK--ILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPAL 111
           F+   + + +   +K   +      +   E   L  L        L     +  ++   +
Sbjct: 96  FKVYALDDGKTYFLKSVKIDAESLTEFTNEKDTLSKLG------RLVGTFFNEQTQVHYI 149

Query: 112 VFEHVNNTDFKQLYQTLTD-------YDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMI 164
           +   +   D  +    L         +++   M  +   +   H +G++HRD+KP N+M+
Sbjct: 150 LTTFIKGIDLSRYKNALPLNVNLKHFWEVLGIMISVCHQVKQFHELGLIHRDLKPGNIML 209

Query: 165 DHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPEL--LVDYQMYDYSLDMWSLGCML 222
           D +  +  L+D+G +      +       +  +  PEL    D+  +    D+++L    
Sbjct: 210 DAD-MQCHLVDFGSSS--SDKEPKPASWGTASYLAPELNAQEDFIAFSQVSDLFAL---A 263

Query: 223 ASMIFRKEPFFH 234
            S+     PF  
Sbjct: 264 YSLDELFNPFRQ 275


>6J6I-B nrPDB
          Length = 351

 Score = 88.9 bits (219), Expect = 4e-18,   Method: Composition-based stats.
 Identities = 45/221 (20%), Positives = 81/221 (36%), Gaps = 27/221 (12%)

Query: 62  NEKVVVKIL-------KPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFE 114
           +   ++K         K  + K++  +I +   +    N + L     +     P LVFE
Sbjct: 81  DRSYMIKRFSEDEITGKRHRVKEVYNDIVLSARMSNHSNFLQLLGCCLEFPF--PVLVFE 138

Query: 115 HVNNTDFKQL-------YQTLTDYDIRF-YMYEILKALDYCHS---MGIMHRDVKPHNVM 163
              +    Q         ++L  + +R     EI  A+ Y H+     I+HRDVKP +V 
Sbjct: 139 FAEHGAMNQRGGVIVNGEESLLPWSVRLKIGKEIANAVTYLHTAFPKIIIHRDVKPMHVF 198

Query: 164 IDHEHRKLRLIDWGLAEFYHPGQEYNVR---VASRYFKGPELLVDYQMYDYSLDMWSLGC 220
           +D ++   +L D   +     G+        + +  +  P L           D++S G 
Sbjct: 199 LD-KNWTAKLSDLSFSISLPEGKSRIEAEWVLGTFGYIDP-LYHKTCFVTEYTDVYSFGI 256

Query: 221 MLASMIFRKEPFFHGHDNYDQ--LVRIAKVLGTEDLYDYID 259
            L  +I  K       D   Q  L  + ++     L + ID
Sbjct: 257 CLLVIITGKPAIMTISDGDLQGILSLVRELCENGKLDEVID 297


>5DMZ-A nrPDB
          Length = 365

 Score = 85.4 bits (210), Expect = 4e-17,   Method: Composition-based stats.
 Identities = 43/247 (17%), Positives = 96/247 (38%), Gaps = 36/247 (14%)

Query: 15  VNTHRPREYWDYESHVVEWGNQDDYQLVRKL-------GRGKYSEVFEAI-----NITNN 62
           V+++     W  +   ++   +  +QL  KL       G G +++V+EA      +  N 
Sbjct: 38  VSSYPNTFEWQCKLPAIKPKTE--FQLGSKLVYVHHLLGEGAFAQVYEATQGDLNDAKNK 95

Query: 63  EKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFK 122
           +K V+K+ KP    +     +++E L+     + +             LV E  +     
Sbjct: 96  QKFVLKVQKPANPWEFYIGTQLMERLKPSMQHMFMKFYSAHLFQNGSVLVGELYSYGTLL 155

Query: 123 QLY--------QTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHE------- 167
                      + +    +  +   +L  ++  H   I+H D+KP N ++ +        
Sbjct: 156 NAINLYKNTPEKVMPQGLVISFAMRMLYMIEQVHDCEIIHGDIKPDNFILGNGFLEQDDE 215

Query: 168 ---HRKLRLIDWGLA---EFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCM 221
                 L LID G +   + +  G  +  +  +  F+  E+L + + ++Y +D + +   
Sbjct: 216 DDLSAGLALIDLGQSIDMKLFPKGTIFTAKCETSGFQCVEMLSN-KPWNYQIDYFGVAAT 274

Query: 222 LASMIFR 228
           +  M+F 
Sbjct: 275 VYCMLFG 281


>4L68-A nrPDB
          Length = 340

 Score = 83.9 bits (206), Expect = 1e-16,   Method: Composition-based stats.
 Identities = 53/270 (19%), Positives = 103/270 (38%), Gaps = 31/270 (11%)

Query: 51  SEVFEAINITNNEKVVVKILKPVK--KKKIKREIKILENLRGGPNIITLADIVKDPVSRT 108
              ++A+ + +   + VK L   K  +++ + E+  L  LR   N+  L       V   
Sbjct: 54  GTTYKAL-LPDGSALAVKHLSTCKLGEREFRYEMNQLWELRHS-NLAPLLGFC--VVEEE 109

Query: 109 PALVFEHVNNTDFKQLY---QTLTDYDIRF-YMYEILKALDYCHSMG---IMHRDVKPHN 161
             LV+++++N     L    +   D+  RF       + L + H      I+H+++    
Sbjct: 110 KFLVYKYMSNGTLHSLLDSNRGELDWSTRFRIGLGAARGLAWLHHGCRPPILHQNICSSV 169

Query: 162 VMIDHEHRKLRLIDWGLAEFYHPGQE-----YNVRVASRYFKGPELLVDYQMYDYSLDMW 216
           ++ID E    R+ID GLA    P            +    +  PE      +     D++
Sbjct: 170 ILID-EDFDARIIDSGLARLMVPSDNNESSFMTGDLGEFGYVAPEY-STTMLASLKGDVY 227

Query: 217 SLGCMLASMIFRKEPF----FHGH--DNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFN 270
            LG +L  +    +      F G   D   QL    ++  T D  +   K + E   +F 
Sbjct: 228 GLGVVLLELATGLKAVGGEGFKGSLVDWVKQLESSGRIAETFD-ENIRGKGHDEEISKFV 286

Query: 271 DI----LGRHSRKRWERFVHSENQHLVSPE 296
           +I    +    ++RW  F   ++   ++ +
Sbjct: 287 EIALNCVSSRPKERWSMFQAYQSLKAIAEK 316


>5C01-A nrPDB
          Length = 342

 Score = 83.5 bits (205), Expect = 1e-16,   Method: Composition-based stats.
 Identities = 37/296 (12%), Positives = 82/296 (27%), Gaps = 69/296 (23%)

Query: 56  AINITNNEKVVVKILKPVKKK---KIKREIKILENLRGGPNIITLADIVKDPVSRTPALV 112
             +     +VV+K+L P              ++  +    ++  +  +          +V
Sbjct: 101 GRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHT-HLAFVHGVCVRGPENI--MV 157

Query: 113 FEHVNNTDFKQLYQT----LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEH 168
            E+V +       +     +          ++  AL Y  +  ++H +V   N+++    
Sbjct: 158 TEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLG 217

Query: 169 RK------LRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDY-QMYDYSLDMWSLGCM 221
                   ++L D G+       +E   R+    +  PE L         ++D W  G  
Sbjct: 218 LAEGTSPFIKLSDPGVGLGALSREERVERI---PWLAPECLPGGANSLSTAMDKWGFGAT 274

Query: 222 LASMIF-RKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKR 280
           L  + F  + P                          +   +      F     R     
Sbjct: 275 LLEICFDGEAP--------------------------LQSRSPSEKEHFYQRQHRLPEPS 308

Query: 281 WERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGS 336
             +                   + L Y+   R +         F T+++D  R+  
Sbjct: 309 CPQLAT-------------LTSQCLTYEPTQRPS---------FRTILRDLTRLQP 342


>5UU1-A nrPDB
          Length = 324

 Score = 83.5 bits (205), Expect = 2e-16,   Method: Composition-based stats.
 Identities = 49/315 (15%), Positives = 106/315 (33%), Gaps = 45/315 (14%)

Query: 26  YESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK--IKREIK 83
            E  V++    + + L +K+G G +  ++ A      EK    ++K   ++   +  E+K
Sbjct: 5   PEGKVLDDMEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELK 64

Query: 84  ILENLRGGPNIITLA----------------DIVKDPVSRTPALVFEHVNNTDFKQLYQ- 126
             + +     I                     + +        +V E +   D +++   
Sbjct: 65  FYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERL-GIDLQKISGQ 123

Query: 127 --TLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEH-RKLRLIDWGLAEFYH 183
             T     +      +L  L+Y H    +H D+K  N+++ +++  ++ L D+GL+  Y 
Sbjct: 124 NGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYC 183

Query: 184 PGQEY--------NVRVASRYFKGPELLVDYQMY--DYSLDMWSLGCMLASMIFRKEPFF 233
           P   +             +  F     L  ++        D+  LG  +   +  K P+ 
Sbjct: 184 PNGNHKQYQENPRKGHNGTIEFTS---LDAHKGVALSRRSDVEILGYCMLRWLCGKLPWE 240

Query: 234 HGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFN--------DILGRHSRKRWERFV 285
               +    V+ AK    ++L   + K+                   L    +  ++   
Sbjct: 241 QNLKDP-VAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALK 299

Query: 286 HSENQHLVSPEALDF 300
              N H +    LDF
Sbjct: 300 KILNPHGIPLGPLDF 314


>4CI6-B nrPDB
          Length = 643

 Score = 83.1 bits (204), Expect = 2e-16,   Method: Composition-based stats.
 Identities = 50/295 (16%), Positives = 107/295 (36%), Gaps = 49/295 (16%)

Query: 57  INITNNEKVVVKILKPVKKKKIKREIKILENL----RGGPNIITLAD--IVKDPVSRTPA 110
           I   + +++V KI + + +  +  E++  +++       PN+  +    +V        A
Sbjct: 63  IETKDKQRLVAKIERSIAEGHLFAELEAYKHIYKTAGKHPNLANVHGMAVVPYGNRYYYA 122

Query: 111 LVFEHVNNTDFKQLYQTLTDY-------------DIRFYMYEILKALDYCHSMGIMHRDV 157
           L+ + V+        ++L D               I+F  + +L   ++    GI+H D+
Sbjct: 123 LLMDEVDGWRCSDTLRSLADSWKQGKINSEAYWGTIKFIAHRLLDVTNHLAKAGIVHNDI 182

Query: 158 KPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWS 217
           KP NV+ D    +  +ID GL      G++      +  FK PEL V         D++ 
Sbjct: 183 KPGNVVFDRASGEPVVIDLGL--HSRSGEQPKGF--TESFKAPELGVGNLGASEKSDVF- 237

Query: 218 LGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHS 277
              ++++++   E F    +      +  + + +E  +   +       P    +   ++
Sbjct: 238 --LVVSTLLHGIEGFEKDPEIKP--NQGLRFITSEPAHVMDENGYPIHRPGIAGVETAYT 293

Query: 278 RKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQA 332
           R                     F+  +L     SR  + EA  H +      D+ 
Sbjct: 294 R---------------------FITDILGVSADSRPDSNEARLHEFLSDGTIDEE 327


>4WOV-A nrPDB
          Length = 317

 Score = 82.7 bits (203), Expect = 3e-16,   Method: Composition-based stats.
 Identities = 34/280 (12%), Positives = 76/280 (27%), Gaps = 60/280 (21%)

Query: 56  AINITNNEKVVVKILKPVKKK---KIKREIKILENLRGGPNIITLADIVKDPVSRTPALV 112
             +     +VV+K+L P              ++  +    ++  +  +          +V
Sbjct: 78  GRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHT-HLAFVHGVCVRGPENI--MV 134

Query: 113 FEHVNNTDFKQLYQT----LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEH 168
            E+V +       +     +          ++  AL Y  +  ++H +V   N+++    
Sbjct: 135 TEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLG 194

Query: 169 RK------LRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDY-QMYDYSLDMWSLGCM 221
                   ++L D G+       +E   R+    +  PE L         ++D W  G  
Sbjct: 195 LAEGTSPFIKLSDPGVGLGALSREERVERI---PWLAPECLPGGANSLSTAMDKWGFGAT 251

Query: 222 LASMIF-RKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKR 280
           L  + F  + P                          +   +      F     R     
Sbjct: 252 LLEICFDGEAP--------------------------LQSRSPSEKEHFYQRQHRLPEPS 285

Query: 281 WERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAME 320
             +                   + L Y+   R + R  + 
Sbjct: 286 CPQLAT-------------LTSQCLTYEPTQRPSFRTILR 312


>6G4J-A nrPDB
          Length = 315

 Score = 81.6 bits (200), Expect = 5e-16,   Method: Composition-based stats.
 Identities = 46/271 (16%), Positives = 101/271 (37%), Gaps = 20/271 (7%)

Query: 35  NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNI 94
           N + Y L ++LG+G    V+ A   T++  V +K+        I  E+ +L++     + 
Sbjct: 24  NGNTYTLRKQLGKGANGIVYLAE--TSDGHVALKV--SDDSLSITSEVNVLKSFSKAQS- 78

Query: 95  ITLADIVKDPVSRTP--------ALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDY 146
           +T+     D                  E++      +         I   M ++L +L  
Sbjct: 79  VTMGPSFFDTDDAYIPSANTKVSFYAMEYIKGPLLLKYVSDKGAEWIPVLMIQLLSSLSV 138

Query: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDW-GLAEFYHPGQEYNVRVASRYFKGPELLVD 205
            H  G +  D+KP N+++     ++R ID  G  +     +EY       Y+        
Sbjct: 139 LHQQGWIFGDLKPDNLIVTGPPARIRCIDVGGTTKEGRAIKEYTEFYDRGYWG-----YG 193

Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIEL 265
            +  + S D++++  ++ + + +KE F   +   +QL  + +       Y       +  
Sbjct: 194 TRKAEPSYDLFAVAMIMINSVHKKE-FKKTNQPKEQLRSLIEGNPLLQKYKKALFSALNG 252

Query: 266 DPRFNDILGRHSRKRWERFVHSENQHLVSPE 296
           D +  D + +      ++    +     SP+
Sbjct: 253 DYQSADEMKKDMLDAGQKAAQRKQPIKASPQ 283


>4I94-A nrPDB
          Length = 300

 Score = 80.0 bits (196), Expect = 1e-15,   Method: Composition-based stats.
 Identities = 48/277 (17%), Positives = 94/277 (33%), Gaps = 56/277 (20%)

Query: 52  EVFEAINITNNEKVVVKILKPV---KKKKIKREIKILENLRGGPNIITLADIVKDPVSRT 108
            V++   + N  ++ VK          ++   E K +  LR    +  L     +   R 
Sbjct: 44  VVYKGK-LENQRRIAVKRFNRKSWPDSRQFLEEAKAVGQLRNHR-MANLLGCCYEDEER- 100

Query: 109 PALVFEHVNNTDFKQLY-----QTLTDYDIRFYMYEILKALDYCHSMG-IMHRDVKPHNV 162
             L+ E + N    +       Q +           I +AL+YC S G  ++ D+  + V
Sbjct: 101 -LLIAEFMPNETLAKHLFHWESQPMKWAMRLRVALHIAQALEYCTSKGRALYHDLNAYRV 159

Query: 163 MIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCML 222
           + D +    RL  +GL +    G+ Y+  +A   F  PE L   ++   S+ ++S G +L
Sbjct: 160 LFDDDANP-RLSCFGLMKNSRDGKSYSTNLA---FTPPEYLRTGRVTPESV-IYSFGTLL 214

Query: 223 ASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWE 282
             ++  K                   +      D I   NI++                 
Sbjct: 215 LDLLSGKH------------------IPPSHALDLIRDRNIQM----------------- 239

Query: 283 RFVHSENQHLVSPEALDFLD---KLLRYDHQSRLTAR 316
                      S +  + +    + L+Y+ + R   +
Sbjct: 240 LMDSGLEGQFSSDDGTELIRLASRCLQYEPRERPNPK 276


>2RSV-A nrPDB
          Length = 403

 Score = 79.3 bits (194), Expect = 3e-15,   Method: Composition-based stats.
 Identities = 46/299 (15%), Positives = 111/299 (37%), Gaps = 45/299 (15%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKV------VVKILKPVKKKKIKREIKILENLRGG 91
           ++++   +G+G +  ++ A ++ ++E V      VVK+ +P     +  E+K  +     
Sbjct: 43  EWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKV-EPSDNGPLFTELKFYQRAAKP 100

Query: 92  PNI--------ITLADI-------VKDPVSR-TPALVFEHVNNTDFKQLY----QTLTDY 131
             I        +    +       + D   +    ++ +    +D +++Y    +  +  
Sbjct: 101 EQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIYEANAKRFSRK 159

Query: 132 DIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEH-RKLRLIDWGLAEFYHPGQEYNV 190
            +      IL  L+Y H    +H D+K  N+++++++  ++ L+D+GLA  Y P   +  
Sbjct: 160 TVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKE 219

Query: 191 R--------VASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQL 242
                      +  F   +            D+  LG  +   +    P+     +    
Sbjct: 220 YKEDPKRCHDGTIEFTSIDAHNGVAP-SRRGDLEILGYCMIQWLTGHLPWEDNLKDPKY- 277

Query: 243 VRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFL 301
           VR +K+   E++   +DK   E      +  G  ++      +    +  +     D L
Sbjct: 278 VRDSKIRYRENIASLMDKCFPE-----KNKPGEIAKYMETVKLLDYTEKPLYENLRDIL 331


>2LAV-A nrPDB
          Length = 361

 Score = 78.1 bits (191), Expect = 6e-15,   Method: Composition-based stats.
 Identities = 46/299 (15%), Positives = 111/299 (37%), Gaps = 45/299 (15%)

Query: 38  DYQLVRKLGRGKYSEVFEAINITNNEKV------VVKILKPVKKKKIKREIKILENLRGG 91
           ++++   +G+G +  ++ A ++ ++E V      VVK+ +P     +  E+K  +     
Sbjct: 36  EWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKV-EPSDNGPLFTELKFYQRAAKP 93

Query: 92  PNI--------ITLADI-------VKDPVSR-TPALVFEHVNNTDFKQLY----QTLTDY 131
             I        +    +       + D   +    ++ +    +D +++Y    +  +  
Sbjct: 94  EQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIYEANAKRFSRK 152

Query: 132 DIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEH-RKLRLIDWGLAEFYHPGQEYNV 190
            +      IL  L+Y H    +H D+K  N+++++++  ++ L+D+GLA  Y P   +  
Sbjct: 153 TVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKE 212

Query: 191 R--------VASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQL 242
                      +  F   +            D+  LG  +   +    P+     +    
Sbjct: 213 YKEDPKRCHDGTIEFTSIDAHNGVAP-SRRGDLEILGYCMIQWLTGHLPWEDNLKDPKY- 270

Query: 243 VRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFL 301
           VR +K+   E++   +DK   E      +  G  ++      +    +  +     D L
Sbjct: 271 VRDSKIRYRENIASLMDKCFPE-----KNKPGEIAKYMETVKLLDYTEKPLYENLRDIL 324


>4IX6-A nrPDB
          Length = 350

 Score = 78.1 bits (191), Expect = 6e-15,   Method: Composition-based stats.
 Identities = 56/338 (16%), Positives = 97/338 (28%), Gaps = 83/338 (24%)

Query: 44  KLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNII-------- 95
            LG G +  VF  +   + + V    LK  K   +  E ++LE        +        
Sbjct: 27  PLGSGNFGTVFRGVFKGDQDVV----LKNAKADVMAAE-ELLECEMDVNYHVHANAKGTC 81

Query: 96  -TLADIVK----DPVSRTPALVFE-----HVNNTD----------------FKQLYQTLT 129
                 ++    D        + E       N  +                         
Sbjct: 82  ARFMGCIELGAKDGGEIYNGTLTEGLWLMWANEGENTVEALMRRGTAPLATAMACADATE 141

Query: 130 DYDIRFYMYEILKALDYCHSMGIMHRDVKPHN-VMIDHEHRKLRLIDWGLAEFYHPGQEY 188
               +  M E+L +L   H  G++HRDVKP N +  + +   L+LID G A    P  E 
Sbjct: 142 LGVTKKAMRELLGSLARLHECGVVHRDVKPANLIAAEKDGGVLKLIDLGAAALCLPLPET 201

Query: 189 ------NVRVASRYFKGPELLVDYQMYDYSL----------------DMWSLGCMLASMI 226
                 +     RY K  EL +                         D WS GC++  + 
Sbjct: 202 LNYYPGDGPADPRYAKADELYLLPPGSPRPTKDNAAKLWEAHKPDRFDSWSAGCVMLQLA 261

Query: 227 FRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVH 286
                           V +    G E           +++    +  G +    +     
Sbjct: 262 V---------------VGLRTDAGLERFLADYKAVGYDVNAFRGEKSGEYGTMDFAALDA 306

Query: 287 SENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324
           +           D   +L+  +  +R +   A+ H +F
Sbjct: 307 NGGAGW------DLCQRLMEAERDARASCEAALSHAFF 338


>4O1O-A nrPDB
          Length = 717

 Score = 69.3 bits (168), Expect = 3e-12,   Method: Composition-based stats.
 Identities = 27/158 (17%), Positives = 61/158 (38%), Gaps = 13/158 (8%)

Query: 24  WDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIK 83
           W      ++    ++Y++      G    ++    +  +++V VK       +  ++E+ 
Sbjct: 337 WRPMIGKLKIFIDEEYKIADT-AEGG---IYLG--LYEDQEVAVKRFSEGSTRG-QQEVS 389

Query: 84  ILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT-----LTDYDIRFYMY 138
            L++ R   N++T      D       L        +    ++        D   R  + 
Sbjct: 390 CLQSSRANDNVVTFYGSESDGSCLHVCLALCEYTLQEHLANHRGDAVPNEEDESARNILS 449

Query: 139 EILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDW 176
            + KA+   H  G  H+D++P N++ID ++    L D+
Sbjct: 450 SLFKAIGELHRSGYSHQDLQPQNILIDSKNGTF-LADF 486



 Score = 31.1 bits (69), Expect = 0.79,   Method: Composition-based stats.
 Identities = 8/35 (22%), Positives = 17/35 (48%), Gaps = 4/35 (11%)

Query: 294 SPEALDFLDKLLR--YDHQSRLTAREAMEHPYFYT 326
             E  D +  L     + + RL++   + HP+F++
Sbjct: 538 DEETRDLIHHLFHPGDNVEDRLSS--LLAHPFFWS 570


>2JII-A nrPDB
          Length = 352

 Score = 63.9 bits (154), Expect = 1e-10,   Method: Composition-based stats.
 Identities = 36/201 (17%), Positives = 77/201 (38%), Gaps = 26/201 (12%)

Query: 126 QTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHR-KLRLIDWGLAEFYHP 184
             L++  +      +L AL++ H    +H +V   N+ +D E + ++ L  +G A  Y P
Sbjct: 154 HVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVDPEDQSQVTLAGYGFAFRYCP 213

Query: 185 GQEYNVRV--------ASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGH 236
             ++   V            F   +L           D+ SLG  +   ++   P+ +  
Sbjct: 214 SGKHVAYVEGSRSPHEGDLEFISMDLHKGCGP-SRRSDLQSLGYCMLKWLYGFLPWTNCL 272

Query: 237 DNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPE 296
            N + +++  +         ++DK    + P  + I    + +++ + V +       P 
Sbjct: 273 PNTEDIMKQKQ--------KFVDKPGPFVGPCGHWIRPSETLQKYLKVVMALTYEEKPPY 324

Query: 297 A--LDFLDKLLR------YDH 309
           A   + L+ LL+      YD 
Sbjct: 325 AMLRNNLEALLQDLRVSPYDP 345


>4OAU-C nrPDB
          Length = 699

 Score = 63.5 bits (153), Expect = 2e-10,   Method: Composition-based stats.
 Identities = 35/181 (19%), Positives = 69/181 (38%), Gaps = 28/181 (15%)

Query: 18  HRPREYWDYESHVVEWGNQDDYQLVRK-LGRGKY-------------SEVFEAINITNNE 63
           H P E W  +S       +D +++ R  +G+ K+               ++        +
Sbjct: 310 HPPAEDWKPQSSHWGAALKDLHRIYRPMIGKLKFFIDEKYKIADTSEGGIYLGF--YEKQ 367

Query: 64  KVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNT---- 119
           +V VK        + +RE+  L++ R   +++T      +       +       T    
Sbjct: 368 EVAVKTF-CEGSPRAQREVSCLQSSRENSHLVTFYGS--ESHRGHLFVCVTLCEQTLEAC 424

Query: 120 -DFKQLYQTLTDYD--IRFYMYEILKALDYCH-SMGIMHRDVKPHNVMIDHEHRKLRLID 175
            D  +      + D   R  +  I KA+   H S G  H+D++P N++ID + +   L D
Sbjct: 425 LDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSK-KAAHLAD 483

Query: 176 W 176
           +
Sbjct: 484 F 484



 Score = 30.3 bits (67), Expect = 1.4,   Method: Composition-based stats.
 Identities = 14/70 (20%), Positives = 27/70 (38%), Gaps = 3/70 (4%)

Query: 294 SPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMS 353
             E  D + +L       R    + + HP+F+T    ++R  +    G  + + +    S
Sbjct: 536 DEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTW---ESRYRTLRNVGNESDIKTRKSES 592

Query: 354 GISSVPTPSP 363
            I  +  P P
Sbjct: 593 EILRLLQPGP 602


>4CYJ-A nrPDB
          Length = 438

 Score = 57.7 bits (138), Expect = 9e-09,   Method: Composition-based stats.
 Identities = 29/163 (17%), Positives = 63/163 (38%), Gaps = 41/163 (25%)

Query: 50  YSE---VFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGP-----NIITLADIV 101
           +     V++A N  N        L+ ++  ++  E  IL  ++        +I+T+ ++ 
Sbjct: 65  FGYPSWVYKAQNSRNGRHYA---LRRLEGYRLTNEKAILNVMKDWKKIKNASIVTIHEVF 121

Query: 102 KDPVSRTPALVFEHVNNTDFKQLYQTLTDYD-------------------IRFYMYEILK 142
                   +L+F +    DF  L +TL ++                    I  Y+ +I  
Sbjct: 122 TTREFGDSSLIFAY----DFHPLSKTLQEHHFQPIHGNRYRPPPAVPENTIWGYICQIAN 177

Query: 143 ALDYCHSMGIMHRDVKPHNVMIDHEHR----KLRLID---WGL 178
           AL   HS  +  R ++P  +++   +R       ++D   +G+
Sbjct: 178 ALKTIHSNRLAARCLEPSKIILTDINRIRLSACAILDVVQFGM 220


>6EWX-A nrPDB
          Length = 484

 Score = 57.7 bits (138), Expect = 9e-09,   Method: Composition-based stats.
 Identities = 34/231 (14%), Positives = 64/231 (27%), Gaps = 78/231 (33%)

Query: 130 DYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRK------------------- 170
           +  + F + ++   L++    GI+HRD+   N+++ H + +                   
Sbjct: 209 ERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLVHCNPQSSPGPSANPSVPTTTSRCP 268

Query: 171 ---------------------LRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMY 209
                                L + ++  A+    G     +  S+    PE++   Q  
Sbjct: 269 SAAPAATTACQGGPGEKHLPRLIISNFLKAKQKPGGTTNLQQKKSQARLAPEIVSASQY- 327

Query: 210 DYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRF 269
               D +  G ++  ++ +  PF    +   QL                           
Sbjct: 328 -RKFDEFQTGILIYELLHQPNPF----EVRAQL--------------------------- 355

Query: 270 NDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAME 320
                R    R E         L SP        LL  D   R+   EA  
Sbjct: 356 -----RERDYRREDLPPLPTLSLYSPGLQQLAHLLLEADPIKRIRIGEAKR 401


>5GZA-A nrPDB
          Length = 290

 Score = 56.5 bits (135), Expect = 2e-08,   Method: Composition-based stats.
 Identities = 36/208 (17%), Positives = 67/208 (32%), Gaps = 38/208 (18%)

Query: 40  QLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK-KKKIKREIKILENLRGGPNIITLA 98
           + V+ +G+G   +V+ +      +KV + +L   +        + +L  L+   +++TL 
Sbjct: 28  RRVKLIGQGAVKKVYLSEWQ--GQKVALSVLSSDQYADDFLHGLSMLRALQSS-HVVTLV 84

Query: 99  DIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRF---YMYEILKALDYCHSMGIMHR 155
            + ++        V E+        L  TL     R+   +   +  A+DY   +  +H 
Sbjct: 85  GVCEEDA----VFVTEYHPLGSVLTLDTTLAQERYRWRNSWHTRLQLAIDYVAFLAYLHS 140

Query: 156 DVKPHNVMIDHEHRKLRLIDWGLAEFYH------------PGQEYNVRVA----SRYFKG 199
                 VM D       L  + LA                      V+      +  F  
Sbjct: 141 SPAGIRVMCDSNDLHKTLSQFLLASDMRLLANDLDALPEVEKGGLGVKCGHHELTGDFVA 200

Query: 200 PELL-----------VDYQMYDYSLDMW 216
           PE L                YD   D+W
Sbjct: 201 PEQLWPYGEDFSFSDEAMPGYDEKTDIW 228


>5GZ9-A nrPDB
          Length = 305

 Score = 56.2 bits (134), Expect = 2e-08,   Method: Composition-based stats.
 Identities = 32/213 (15%), Positives = 77/213 (36%), Gaps = 39/213 (18%)

Query: 36  QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL-KPVKKKKIKREIKILENLRGGPNI 94
           + + + ++++G G    VF +       KV +  L +   K+     +++L++L+   ++
Sbjct: 33  RTEVRQLKRVGEGAVKRVFLSEWKE--HKVALSRLTRLEMKEDFLHGLQMLKSLQ-SEHV 89

Query: 95  ITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTD---YDIRFYMYEILKALDYCHSMG 151
           +TL    ++  +    ++ E+        L +TL      D+  + + +  A++Y   + 
Sbjct: 90  VTLVGYCEEDGT----ILTEYHPLGSLSNLEETLQLSKYQDVNTWQHRLQLAMEYVSIIN 145

Query: 152 IMH------RDVKPHNVM-------IDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY-- 196
            +H      R +   N +       +   +  +   D              ++   R   
Sbjct: 146 YLHHSPLGTRVMCDSNDLPKTLSQYLLTSNFSIVANDLDALPLVDHDSGVLIKCGHRELH 205

Query: 197 --FKGPELLVDYQ-----------MYDYSLDMW 216
             F  PE L  Y             Y+  +D+W
Sbjct: 206 GDFVAPEQLWPYGEDTPFQDDLMPSYNEKVDIW 238


>4AZW-A nrPDB
          Length = 471

 Score = 52.7 bits (125), Expect = 3e-07,   Method: Composition-based stats.
 Identities = 28/114 (24%), Positives = 43/114 (37%), Gaps = 23/114 (20%)

Query: 74  KKKKIKREIKILEN----------LRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQ 123
            K ++  EIK L            L  G N            +++  LV E +       
Sbjct: 284 NKHELHNEIKFLTQPPAGFDAPAVLAHGEN------------AQSGWLVMEKLPGRLLSD 331

Query: 124 LYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWG 177
           +     + D    +  +L++L      G  H DV+P NVM+D      RLID+G
Sbjct: 332 MLAAGEEIDREKILGSLLRSLAALEKKGFWHDDVRPWNVMVDARQHA-RLIDFG 384


>6M7Z-A nrPDB
          Length = 319

 Score = 52.7 bits (125), Expect = 3e-07,   Method: Composition-based stats.
 Identities = 37/255 (14%), Positives = 79/255 (30%), Gaps = 64/255 (25%)

Query: 97  LADIVKDPVSRTPALVFEHVNNTDFKQLYQT-LTDYDIRFYMYEILKALDYCHSMGIMHR 155
           L   + +        +F  ++      + +T  +  D++     ++ AL   H++G++HR
Sbjct: 109 LLPSLGEYRGAFLTYIFHPLSKGLVGDMLETGRSHPDVQVLAANMVAALKSLHNLGLLHR 168

Query: 156 DVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYF---KGPEL--------LV 204
            ++  N         + L   GL      G E  + V   +F     PE+         +
Sbjct: 169 SIEL-NSFSVLPDGTVVLG--GLDTAAPIGTETRLWVG--FFGQETAPEIDRNFLADLAL 223

Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIE 264
               +    D++SLG                         + ++LG           N  
Sbjct: 224 TQGRHTVKSDVYSLGV--------------------AFRNLVQLLG-----------NGN 252

Query: 265 LDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324
           L P     + +   +  ++                   K++  +  +R T  E M+ P F
Sbjct: 253 LGPEDRGAVRQDHLELLDK----------------LSQKMIEEEPGNRPTIEEIMKDPLF 296

Query: 325 YTVVKDQARMGSSSM 339
             +  +    G +  
Sbjct: 297 EGLNFEDIEEGKARP 311


>6EAS-A nrPDB
          Length = 308

 Score = 52.3 bits (124), Expect = 4e-07,   Method: Composition-based stats.
 Identities = 33/280 (11%), Positives = 84/280 (30%), Gaps = 55/280 (19%)

Query: 54  FEAINITNNEKVVV--------KILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPV 105
           ++   +++  ++ V        K      + + +++I  L  +    N + L    ++  
Sbjct: 57  YKGT-LSSGVEIAVASSLVTSAKDWSKENESQYRKKITNLSKVSH-KNFMNLLGYCEEEH 114

Query: 106 SRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMY-----EILKALDYCHSMGI--MHRDVK 158
             T  +VFE+  N    +         + +         I   L++ H +      R+  
Sbjct: 115 PFTRVMVFEYAPNGTLFEHLHVREAEKLDWMARLRISMGIAYCLEHMHQLQTPAALRNFD 174

Query: 159 PHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSL 218
              V +  +    ++ D    EF++  + +N    +     P++    + Y         
Sbjct: 175 STTVYLT-DDFAAKVSDL---EFWNDAKGHNSTTNNELAFSPDMEDIVRKY--------- 221

Query: 219 GCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSR 278
           G +L  ++  + P        +  V           ++   +    +DP         +R
Sbjct: 222 GMVLLEILTGRVPSSEDDGPLENWV--------SRYFEGGMRLEELIDPSIGFFPEDTAR 273

Query: 279 KRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREA 318
              E                  +   +  D + R   +E 
Sbjct: 274 ALCEV-----------------VRSCIDRDPKKRPQMKEV 296


>4AZV-A nrPDB
          Length = 569

 Score = 52.3 bits (124), Expect = 4e-07,   Method: Composition-based stats.
 Identities = 28/114 (24%), Positives = 43/114 (37%), Gaps = 23/114 (20%)

Query: 74  KKKKIKREIKILEN----------LRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQ 123
            K ++  EIK L            L  G N            +++  LV E +       
Sbjct: 284 NKYELHNEIKFLTQPPAGFDAPAVLAHGEN------------AQSGWLVMEKLPGRLLSD 331

Query: 124 LYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWG 177
           +     + D    +  +L++L      G  H DV+P NVM+D      RLID+G
Sbjct: 332 MLAAGEEIDREKILGSLLRSLAALEKQGFWHDDVRPWNVMVDARQHA-RLIDFG 384


>6BHC-A nrPDB
          Length = 438

 Score = 49.2 bits (116), Expect = 3e-06,   Method: Composition-based stats.
 Identities = 29/197 (14%), Positives = 61/197 (30%), Gaps = 36/197 (18%)

Query: 128 LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE 187
           L +  +   + ++   L++     + H D++  N+++ H         +G AE       
Sbjct: 175 LYERQVCLLLLQLCSGLEHLKPYHVTHCDLRLENLLLVHYQPGGTAQGFGPAEPTPTSSY 234

Query: 188 YNVRVAS-------------RYF------KGPELLVDYQMYDYSLDMWSLGCMLASMIFR 228
               + S                        PE++   Q      D +  G ++  M+  
Sbjct: 235 PTRLIVSNFSQAKQKSHLVDPEILRDQSRLAPEIITATQY--KKCDEFQTGILIYEMLHL 292

Query: 229 KEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSE 288
             PF    D   +L         E  Y   D   I     ++  L + +         + 
Sbjct: 293 PNPF----DENPELK--------EREYTRADLPRIPFRSPYSRGLQQLASCL---LNPNP 337

Query: 289 NQHLVSPEALDFLDKLL 305
           ++ ++  +A   L  LL
Sbjct: 338 SERILISDAKGILQCLL 354


>5VE6-A nrPDB
          Length = 492

 Score = 49.2 bits (116), Expect = 3e-06,   Method: Composition-based stats.
 Identities = 9/37 (24%), Positives = 21/37 (56%)

Query: 130 DYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDH 166
           +  + F + ++   L++    GI+HRD+   N+++ H
Sbjct: 207 ERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLVH 243



 Score = 34.2 bits (77), Expect = 0.10,   Method: Composition-based stats.
 Identities = 21/123 (17%), Positives = 31/123 (25%), Gaps = 38/123 (30%)

Query: 198 KGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDY 257
             PE++   Q      D +  G ++  ++ +  PF    +   QL               
Sbjct: 325 LAPEIVSASQY--RKFDEFQTGILIYELLHQPNPF----EVRAQL--------------- 363

Query: 258 IDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTARE 317
                            R    R E         L SP        LL  D   R+   E
Sbjct: 364 -----------------RERDYRQEDLPPLPALSLYSPGLQQLAHLLLEADPIKRIRIGE 406

Query: 318 AME 320
           A  
Sbjct: 407 AKR 409


>3ENH-A nrPDB
          Length = 540

 Score = 49.2 bits (116), Expect = 3e-06,   Method: Composition-based stats.
 Identities = 26/154 (16%), Positives = 62/154 (40%), Gaps = 24/154 (15%)

Query: 45  LGRGKYSEVFEAINITNNEKVVVK-ILKP----------VKKKKIKREIKILENLRGGPN 93
           +G+G  +++    +   +  V++K  +K           ++K +  RE + L  ++    
Sbjct: 344 IGKGAEADIK--RDSYLDFDVIIKERVKKGYRDERLDENIRKSRTAREARYLALVKD--F 399

Query: 94  IITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIM 153
            I    I    +     +   ++N    K + +     D     Y+I + +   H   ++
Sbjct: 400 GIPAPYIFDVDLDNKRIM-MSYINGKLAKDVIE-----DNLDIAYKIGEIVGKLHKNDVI 453

Query: 154 HRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE 187
           H D+   N + D +   L +ID+GL +  +  ++
Sbjct: 454 HNDLTTSNFIFDKD---LYIIDFGLGKISNLDED 484


>1TQM-A nrPDB
          Length = 282

 Score = 48.5 bits (114), Expect = 5e-06,   Method: Composition-based stats.
 Identities = 34/157 (21%), Positives = 64/157 (40%), Gaps = 35/157 (22%)

Query: 41  LVRKLGRGKYSEVFEAINITNNEKVVVKI-------LKPVKKKK--------------IK 79
           + + +G GK S VF   +    E V VK         K VK+K+               +
Sbjct: 94  IGKLMGEGKESAVFNCYSEKFGECV-VKFHKVGHTSFKKVKEKRDYGDLHFSVLAIRSAR 152

Query: 80  REIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYE 139
            E + L+ L+G         + K       A++ E ++  +  ++     D  +   + E
Sbjct: 153 NEFRALQKLQG-------LAVPKVYAWEGNAVLMELIDAKELYRVRVENPDEVLDMILEE 205

Query: 140 ILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDW 176
           + K   + H  GI+H D+  +NV++  E   + +ID+
Sbjct: 206 VAK---FYH-RGIVHGDLSQYNVLVSEEG--IWIIDF 236


>6G38-A nrPDB
          Length = 357

 Score = 48.5 bits (114), Expect = 5e-06,   Method: Composition-based stats.
 Identities = 37/221 (16%), Positives = 67/221 (30%), Gaps = 77/221 (34%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL-----------KPVKKKKIKREIKIL 85
           +  Q   K+G G + EVF    I ++  V +KI+                ++I  EI I 
Sbjct: 41  EKLQRCEKIGEGVFGEVF--QTIADHTPVAIKIIAIEGPDLVNGSHQKTFEEILPEIIIS 98

Query: 86  ENLR----------------GGPNIIT-----LA------------------DIVKDPVS 106
           + L                    + +      L                   D  KD   
Sbjct: 99  KELSLLSGEVCNRTEGFIGLNSVHCVQGSYPPLLLKAWDHYNSTKGSANDRPDFFKD--- 155

Query: 107 RTPALVFEH-VNNTDFKQLYQTL-TDYDIRFYMYEILKALDYCH-SMGIMHRDVKPHNVM 163
               +V E      D +Q+   L +    +  ++++  +L     S+   HRD+   NV+
Sbjct: 156 DQLFIVLEFEFGGIDLEQMRTKLSSLATAKSILHQLTASLAVAEASLRFEHRDLHWGNVL 215

Query: 164 -------------------IDHEHRKLRLIDWGLAEFYHPG 185
                              I     ++ +ID+ L+     G
Sbjct: 216 LKKTSLKKLHYTLNGKSSTIPSCGLQVSIIDYTLSRLERDG 256


>4WWA-A nrPDB
          Length = 261

 Score = 45.4 bits (106), Expect = 4e-05,   Method: Composition-based stats.
 Identities = 26/151 (17%), Positives = 54/151 (35%), Gaps = 29/151 (19%)

Query: 54  FEAINITNNEKVVVKILKPVK-----------KKKIKREIKILENLRGGPN--IITLADI 100
           +      +++K ++K   P +           K +   E ++L  L   P   +  L   
Sbjct: 38  YLPRAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIAC 97

Query: 101 VKDPVSRTPALVF--EHVNNT----DFKQLYQTLTDYD-----IRFYMYEILKALDYCHS 149
             DP +    L F  E +       + K     + D D     +   + ++ + +   H 
Sbjct: 98  --DPYNGFIWLEFLGEDLPGGHGFSNLKNFL-WMHDQDPYSDLVATTLRKVGRQIGLLHW 154

Query: 150 MGIMHRDVKPHNVMIDHEHRKL--RLIDWGL 178
               H D+   N+++  +  +    LID+GL
Sbjct: 155 NDYCHGDLTSSNIVLVRDGARWTPHLIDFGL 185


>4CZY-B nrPDB
          Length = 429

 Score = 45.0 bits (105), Expect = 6e-05,   Method: Composition-based stats.
 Identities = 22/142 (15%), Positives = 54/142 (38%), Gaps = 26/142 (18%)

Query: 54  FEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGP-----NIITLADIVKDPVSRT 108
           ++A N  N        L+ ++  ++  E  IL   +        NI+T+ +         
Sbjct: 61  YKAQNNKNGRHFA---LRRIEGYRLTNEKAILNVTKEWKKIINANIVTVHEAFTTEFFGD 117

Query: 109 PALVFEH----VNNTDFKQLY------------QTLTDYDIRFYMYEILKALDYCHSMGI 152
            +L+F +    ++ T +   +              + +  +  Y+ +I  AL   H+  +
Sbjct: 118 SSLIFVYDFHPLSETLYDHHFPPNNSHNRLRNTNKIPENLLWSYVCQIANALLAIHNAKL 177

Query: 153 MHRDVKPHNVMIDHEHRKLRLI 174
             R ++   ++   E+ ++RL 
Sbjct: 178 AARCLELSKII--WENNRIRLA 197


>2W1Z-A nrPDB
          Length = 368

 Score = 43.1 bits (100), Expect = 2e-04,   Method: Composition-based stats.
 Identities = 49/325 (15%), Positives = 98/325 (30%), Gaps = 71/325 (21%)

Query: 33  WGNQDDYQLVRKLGR--------------GKYSEVFEAINITNNEKV------------- 65
           W N+  +++  +LG               G Y    EA +    E +             
Sbjct: 41  WRNEQSFRVESELGERPRTLVRGPVLRDDGSY-ICLEATDQETGEPLEVHVPYFTERPPS 99

Query: 66  -VVKILKP-VKKKKIKREIKILENLRGGPNIITLADIVKDP---------VSRTPALVF- 113
             +K L   V + ++ R IK     +     I   D+VKDP         +      V  
Sbjct: 100 NAIKQLSEQVLRLRLLRGIKNQRQAKAYLRFIFPIDLVKDPKKRKMIRVRLDERDMWVLS 159

Query: 114 -----------EHVNNTDFKQL---YQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKP 159
                       H+           +++L  +       ++++        G++H D + 
Sbjct: 160 RFFLYPRMQSNLHILGDVLLSHSSTHKSLVHHARLQLTLQLIRLAASLQHYGLVHADFQV 219

Query: 160 HNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPE-----LLVDYQMY----D 210
            N+++D     + L   G       G      +  R F  PE     +L   Q +     
Sbjct: 220 RNILLDQRGG-VFLT--GFEHLVRDGASAVSPIG-RGFAPPETTAERMLPYRQHHPTLMT 275

Query: 211 YSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFN 270
           +  D W+LG  +  +     P    +    +L  I  +           +  +E   R++
Sbjct: 276 FPFDTWTLGLAIYWIWCADLP----NTEDAELGGIEWIYRRCKNIPQPVRALLEGFLRYS 331

Query: 271 DILGRHSRKRWERFVHSENQHLVSP 295
                   +  E   + + +  +S 
Sbjct: 332 KEDRLLPLQAMETSEYEQLRTELSA 356


>3BYV-A nrPDB
          Length = 377

 Score = 42.7 bits (99), Expect = 3e-04,   Method: Composition-based stats.
 Identities = 41/228 (17%), Positives = 79/228 (34%), Gaps = 57/228 (25%)

Query: 55  EAINITNNEKV--------------VVKILKP-VKKKKIKREIKILENLRGGPNIITLAD 99
           EA +    E                 +K +K  V + ++ R IK  +  +     I   D
Sbjct: 91  EATDQETGESFEVHVPYFTERPPSNAIKQMKEEVLRLRLLRGIKNQKQAKVHLRFIFPFD 150

Query: 100 IVKDPVSRTPALVFEHVNNTDFKQL--------------------------YQTLTDYDI 133
           +VKDP  +    V   ++  D   L                          +++L  +  
Sbjct: 151 LVKDPQKKKMIRV--RLDERDMWVLSRFFLYPRMQSNLQTFGEVLLSHSSTHKSLVHHAR 208

Query: 134 RFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVA 193
                ++++ L   H  G++H  ++P ++++D     + L   G       G      V 
Sbjct: 209 LQLTLQVIRLLASLHHYGLVHTYLRPVDIVLDQRGG-VFLT--GFEHLVRDGARVVSSV- 264

Query: 194 SRYFKGPEL------LVDYQMY----DYSLDMWSLGCMLASMIFRKEP 231
           SR F+ PEL      +  ++       +S D W+LG ++  +     P
Sbjct: 265 SRGFEPPELEARRATISYHRDRRTLMTFSFDAWALGLVIYWIWCADLP 312


>3DZO-A nrPDB
          Length = 413

 Score = 41.1 bits (95), Expect = 0.001,   Method: Composition-based stats.
 Identities = 45/263 (17%), Positives = 87/263 (33%), Gaps = 71/263 (26%)

Query: 33  WGNQDDYQLVRKLG-------RGK-------YSEVFEAINITNNEKV------------- 65
           W     +++  +LG       RG        Y+   EA +    E               
Sbjct: 61  WNTGQPFRVESELGERPRTLVRGTVLGQEDPYAY-LEATDQETGESFEVHVPYFTERPPS 119

Query: 66  -VVKILKP-VKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQ 123
             +K +K  V + ++ R IK  +  +     I   D+VKDP  +    V   ++  D   
Sbjct: 120 NAIKQMKEEVLRLRLLRGIKNQKQAKVHLRFIFPFDLVKDPQKKKMIRV--RLDERDMWV 177

Query: 124 L--------------------------YQTLTDYDIRFYMYEILKALDYCHSMGIMHRDV 157
           L                          +++L  +       ++++ L   H  G++H  +
Sbjct: 178 LSRFFLYPRMQSNLQTFGEVLLSHSSTHKSLVHHARLQLTLQVIRLLASLHHYGLVHTYL 237

Query: 158 KPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPE-----LLVDYQMY--- 209
           +P ++++D     + L   G       G      +  R F  PE     +L   Q +   
Sbjct: 238 RPVDIVLDQRGG-VFLT--GFEHLVRDGASAVSPIG-RGFAPPETTAERMLPFGQHHPTL 293

Query: 210 -DYSLDMWSLGCMLASMIFRKEP 231
             ++ D W+LG  +  +     P
Sbjct: 294 MTFAFDTWTLGLAIYWIWCADLP 316


>4BVU-A nrPDB
          Length = 211

 Score = 39.6 bits (91), Expect = 0.003,   Method: Composition-based stats.
 Identities = 26/161 (16%), Positives = 60/161 (37%), Gaps = 16/161 (9%)

Query: 21  REYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIK- 79
           +  + +E++    G   +  L + +G+G  +E+FE +N ++       ++     + ++ 
Sbjct: 24  QTPFPFENNNSHAGIVTEPILGKLIGQGSTAEIFEDVNDSSALYKKYDLIGNQYNEILEM 83

Query: 80  --REIKILENLRGGPN--IITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRF 135
             +E ++     G     +I               L    V  T    +       +I  
Sbjct: 84  AWQESELFNAFYGDEASVVIQYGG--------DVYLRMLRVPGTPLSDIDTADIPDNIES 135

Query: 136 YMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDW 176
              +++  L+      I+H D+   N++ D E   L  ID+
Sbjct: 136 LYLQLICKLNEL---SIIHYDLNTGNMLYDKESESLFPIDF 173


>3Q60-A nrPDB
          Length = 371

 Score = 39.2 bits (90), Expect = 0.003,   Method: Composition-based stats.
 Identities = 39/220 (17%), Positives = 75/220 (34%), Gaps = 34/220 (15%)

Query: 120 DFKQLYQTLTDYDIRFYM-YEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGL 178
           DF  +++          +  ++++      S G++H    P N+ I  + R L L D  +
Sbjct: 182 DFVYVFRGDEGILALHILTAQLIRLAANLQSKGLVHGHFTPDNLFIMPDGR-LMLGD--V 238

Query: 179 AEFYHPGQEYNVRVASRYFKGPELLVDYQ-MYDYSLDMWSLGCMLASMIFRKEPFFHGHD 237
           +  +  G           +   E L      + ++L+ W LG  +  +     PF     
Sbjct: 239 SALWKVGTRGPASSVPVTYAPREFLNASTATFTHALNAWQLGLSIYRVWCLFLPF----- 293

Query: 238 NYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEA 297
                      L T  +     + ++ +     D L   S      FV +          
Sbjct: 294 ----------GLVTPGIKGSWKRPSLRVPGT--DSLAFGSCTPLPDFVKT---------- 331

Query: 298 LDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSS 337
              + + L +D + RL   EAME P F  +  + +   S+
Sbjct: 332 --LIGRFLNFDRRRRLLPLEAMETPEFLQLQNEISSSLST 369


>5YK0-A nrPDB
          Length = 452

 Score = 38.4 bits (88), Expect = 0.005,   Method: Composition-based stats.
 Identities = 31/168 (18%), Positives = 61/168 (36%), Gaps = 43/168 (25%)

Query: 51  SEVFEAINITNNEKVVVKILKP-------VKKKKIKREIKILENLRGGPNIITLADIVKD 103
            +V +AI  ++  +V VKI  P          K ++R + +L+ L  G ++  + D + +
Sbjct: 146 GQVHKAIW-SDGREVAVKIQYPGADEALRADLKTMQRMVGVLKQLSPGADVQGVVDELVE 204

Query: 104 PVSRTPALVFEHVNNTDFKQLYQTLTDYDI--------RFYMYEILKAL----------- 144
                     E  N   F + Y     + +        +  + E ++ +           
Sbjct: 205 RTEMELDYRLEAANQRAFAKAYHDHPRFQVPHVVASAPKVVIQEWIEGVPMAEIIRHGTT 264

Query: 145 ---------------DYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWG 177
                          D    +G+MH D  P N M+  + R + +ID+G
Sbjct: 265 EQRDLIGTLLAELTFDAPRRLGLMHGDAHPGNFMLLPDGR-MGIIDFG 311


>4BWP-A nrPDB
          Length = 448

 Score = 37.3 bits (85), Expect = 0.012,   Method: Composition-based stats.
 Identities = 16/163 (9%), Positives = 50/163 (30%), Gaps = 42/163 (25%)

Query: 54  FEAINITNNEKVVVKIL--KPVKKKKIKREIKILENLRGGPNIITLADIVKDP--VSRTP 109
           + A + T   K  ++ +    ++  K    +++ + L+   N++ L ++         + 
Sbjct: 67  YRATHNTTGYKYCLRRIHGFRLQSTKCMTLVEMWKKLQHT-NVVQLREVFTTKAFGDNSL 125

Query: 110 ALVFEHVNN-----------------------TDFKQLYQT-----------LTDYDIRF 135
            LV+++                           + +                L +  I  
Sbjct: 126 VLVYDYHPGSQTLLAKYFTPAPETNGYTDPFQGEARPFSHKSNMQRTSNGPLLPEATIWS 185

Query: 136 YMYEILKALDYCHSMGIMHRDVKPHNVMIDHEH---RKLRLID 175
            + ++   L   H  G+  + + P  +++  +        + D
Sbjct: 186 IIMQLTAGLKAIHHAGLACKVLDPTKIIVTGKRVRFSSCCISD 228


>6G18-v nrPDB
          Length = 552

 Score = 36.1 bits (82), Expect = 0.028,   Method: Composition-based stats.
 Identities = 18/99 (18%), Positives = 38/99 (38%), Gaps = 9/99 (9%)

Query: 78  IKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYM 137
             +E   ++ L      +      K       A+V E +N     Q++       +    
Sbjct: 158 AMKEFAYMKALYERKFPVP-----KPIDYNRHAVVMELINGYPLCQIHHVEDPASVYDEA 212

Query: 138 YEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDW 176
            E++  L    + G++H D    N+++D E   + +ID+
Sbjct: 213 MELIVKLA---NHGLIHGDFNEFNLILD-ESDHITMIDF 247


>5I35-A nrPDB
          Length = 393

 Score = 36.1 bits (82), Expect = 0.029,   Method: Composition-based stats.
 Identities = 28/175 (16%), Positives = 49/175 (28%), Gaps = 43/175 (24%)

Query: 51  SEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNII-------TLADIVK- 102
            +V  A  +    +V +KI  P   + I  ++  L  +    N++        L D+++ 
Sbjct: 88  GQVHLAR-MKGGREVAMKIQYPGVAQSINSDVNNLMAVLNMSNMLPEGLFPEHLIDVLRR 146

Query: 103 ------------------------DPVSRTPALVFEHVNNTDF-KQLYQTLTDYDIRFYM 137
                                    P    P +V E  +      +L             
Sbjct: 147 ELALECDYQREAACARKFRDLLKGHPFFYVPEIVDELCSPHVLTTELVSGFPLDQAEGLS 206

Query: 138 YEI---------LKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH 183
            EI         +  L        M  D    N   D +  K+ L+D+G    Y 
Sbjct: 207 QEIRNEICYNILVLCLRELFEFHFMQTDPNWSNFFYDPQQHKVALLDFGATREYD 261


>6FDN-A nrPDB
          Length = 320

 Score = 35.4 bits (80), Expect = 0.048,   Method: Composition-based stats.
 Identities = 18/99 (18%), Positives = 38/99 (38%), Gaps = 9/99 (9%)

Query: 78  IKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYM 137
             +E   ++ L      +      K       A+V E +N     Q++       +    
Sbjct: 158 AMKEFAYMKALYERKFPVP-----KPIDYNRHAVVMELINGYPLCQIHHVEDPASVYDEA 212

Query: 138 YEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDW 176
            E++  L    + G++H D    N+++D E   + +ID+
Sbjct: 213 MELIVKLA---NHGLIHGDFNEFNLILD-ESDHITMIDF 247


>6EF6-A nrPDB
          Length = 354

 Score = 31.9 bits (71), Expect = 0.47,   Method: Composition-based stats.
 Identities = 8/28 (28%), Positives = 18/28 (64%), Gaps = 2/28 (7%)

Query: 151 GIMHRDVKPHNVMIDHEH--RKLRLIDW 176
           G++H D++  N+++D     R + +ID+
Sbjct: 226 GLIHADLRLANLLVDSSTPQRTITVIDF 253


>4BFR-A nrPDB
          Length = 952

 Score = 31.9 bits (71), Expect = 0.50,   Method: Composition-based stats.
 Identities = 9/64 (14%), Positives = 22/64 (34%), Gaps = 11/64 (17%)

Query: 114 EHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRL 173
           E+ +  D  +  +  T     + +   +  +   HS           N+M+    +   +
Sbjct: 769 EYNSGDDLDRAIEEFTLSCAGYCVASYVLGIGDRHS----------DNIMVKKTGQLFHI 818

Query: 174 IDWG 177
            D+G
Sbjct: 819 -DFG 821


>4P4S-A nrPDB
          Length = 303

 Score = 30.7 bits (68), Expect = 1.3,   Method: Composition-based stats.
 Identities = 12/55 (21%), Positives = 27/55 (49%), Gaps = 12/55 (21%)

Query: 313 LTAREAME--------HPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVP 359
           L+  EA++        HPYF  ++++    G +++P  +  ++S  +     S+P
Sbjct: 233 LSLSEALQREKIFFENHPYFRDLLEE----GKATVPSLAEKLTSELITHISKSLP 283


>4P4S-B nrPDB
          Length = 346

 Score = 30.3 bits (67), Expect = 1.4,   Method: Composition-based stats.
 Identities = 12/55 (21%), Positives = 27/55 (49%), Gaps = 12/55 (21%)

Query: 313 LTAREAME--------HPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVP 359
           L+  EA++        HPYF  ++++    G +++P  +  ++S  +     S+P
Sbjct: 248 LSLSEALQREKIFFENHPYFRDLLEE----GKATVPSLAEKLTSELITHISKSLP 298


>6DFL-A nrPDB
          Length = 259

 Score = 30.3 bits (67), Expect = 1.4,   Method: Composition-based stats.
 Identities = 26/198 (13%), Positives = 62/198 (31%), Gaps = 39/198 (19%)

Query: 33  WGNQDDYQLVRKLGRGKYSEVFE-------AINITNNEKVVVKILK-------------- 71
           W  +D ++ V  L      +V+             +     VKI +              
Sbjct: 13  WNGRDPFEAVEAL----QGKVYRELEGRRTLRTEVDGRGYFVKIHRGIGWGEIAKNLLTA 68

Query: 72  PVKKKKIKREIKILENLRGGPNI-----ITLADIVKDPVSRTPALVFEHVNNT-DFKQLY 125
            +     ++E + +  L     +     +   +   DP  +   +V E +  T D +   
Sbjct: 69  KLPVLGARQEWQAIRRL-HEAGVATMTAVAYGERGSDPARQHSFIVTEELAPTVDLEVFS 127

Query: 126 QTLTDYD-----IRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE 180
           Q   +        R  +  + + +   H  G+ HRD    + ++ H  + +   D+ L+ 
Sbjct: 128 QDWRERPPPPRLKRALVEAVARMVGDMHRAGVNHRDCYICHFLL-HTDKPVSADDFRLS- 185

Query: 181 FYHPGQEYNVRVASRYFK 198
                +        + ++
Sbjct: 186 VIDLHRAQTRDATPKRWR 203


>2Y0O-A nrPDB
          Length = 175

 Score = 30.3 bits (67), Expect = 1.5,   Method: Composition-based stats.
 Identities = 13/47 (27%), Positives = 25/47 (53%)

Query: 158 KPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLV 204
           K   V+ D E  +++L+D+GL +    G +  V V +  +   EL++
Sbjct: 14  KAGIVLTDEEVDQIQLMDYGLGKERKVGLQLFVYVNTDRYCSKELVL 60


>4H05-A nrPDB
          Length = 273

 Score = 30.0 bits (66), Expect = 1.7,   Method: Composition-based stats.
 Identities = 10/27 (37%), Positives = 16/27 (59%), Gaps = 1/27 (3%)

Query: 152 IMHRDVKPHNVMIDHEHRKLR-LIDWG 177
           + H D+ P NV++D    ++  LID G
Sbjct: 186 VCHGDLCPDNVLLDPRTCEVTGLIDVG 212


>4ESA-B nrPDB
          Length = 146

 Score = 30.0 bits (66), Expect = 2.0,   Method: Composition-based stats.
 Identities = 20/69 (28%), Positives = 29/69 (42%), Gaps = 14/69 (20%)

Query: 48  GKYSEVFEAINITNNEKVV---VKIL--------KPVKKKKIKREIKIL--ENLRGGP-N 93
           G +  ++ A  I  N+KV    +K+L             K+I  E+ IL  E L   P N
Sbjct: 43  GSFGNLYNAEAIIGNQKVAAHGIKVLHGLDRAVKNMDNIKEIYAELSILHSEKLHVDPDN 102

Query: 94  IITLADIVK 102
              LAD + 
Sbjct: 103 FKLLADCLT 111


>5H12-A nrPDB
          Length = 775

 Score = 29.6 bits (65), Expect = 2.2,   Method: Composition-based stats.
 Identities = 14/32 (43%), Positives = 19/32 (59%)

Query: 51  SEVFEAINITNNEKVVVKILKPVKKKKIKREI 82
           ++V EAI    N +  VKI+K V +K  K EI
Sbjct: 625 AKVLEAILKHGNVEEAVKIVKEVTEKLSKYEI 656


>3VYS-B nrPDB
          Length = 372

 Score = 29.6 bits (65), Expect = 2.3,   Method: Composition-based stats.
 Identities = 7/40 (17%), Positives = 21/40 (52%), Gaps = 2/40 (5%)

Query: 63  EKVVVKILKPVKKKK--IKREIKILENLRGGPNIITLADI 100
            +V +K+++ ++++   +  EI+I+       + +T   I
Sbjct: 11  REVAMKLVEKIREEAKTLDGEIRIMHVCGTHEDTVTRHGI 50


>4W6Q-A nrPDB
          Length = 333

 Score = 29.6 bits (65), Expect = 2.6,   Method: Composition-based stats.
 Identities = 17/51 (33%), Positives = 23/51 (45%), Gaps = 7/51 (13%)

Query: 4   PVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVF 54
            +P+   VYTD N   P         VV+   Q D QL+ K+  G Y  V+
Sbjct: 189 RIPTELHVYTDHNMQLPTT-------VVKEPYQSDEQLIMKMSEGGYGLVW 232


>2P8J-A nrPDB
          Length = 209

 Score = 29.2 bits (64), Expect = 3.4,   Method: Composition-based stats.
 Identities = 11/59 (18%), Positives = 24/59 (40%), Gaps = 9/59 (15%)

Query: 37  DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNII 95
           + Y    K+G G++      + +   EKV   I   V  ++  +  K ++ L     ++
Sbjct: 134 ERYNKGEKIGEGEF------LQLERGEKV---IHSYVSLEEADKYFKDMKVLFKEDRVV 183


>2GB3-A nrPDB
          Length = 409

 Score = 29.2 bits (64), Expect = 3.5,   Method: Composition-based stats.
 Identities = 11/32 (34%), Positives = 17/32 (53%), Gaps = 2/32 (6%)

Query: 156 DVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE 187
           DVKP NV++ +   +  L  +  A   +PG E
Sbjct: 99  DVKPENVLVTNGGSEAIL--FSFAVIANPGDE 128


>1CJA-A nrPDB
          Length = 342

 Score = 28.8 bits (63), Expect = 3.9,   Method: Composition-based stats.
 Identities = 15/84 (17%), Positives = 33/84 (39%), Gaps = 11/84 (13%)

Query: 234 HGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKR----------WER 283
            GH++  Q   I  ++     YD   + +I +   F   +   +             W+ 
Sbjct: 258 PGHESS-QFHSIRDIITLYTGYDVGTEGSISMQEGFLATVRECASFDLDAFERELLSWQE 316

Query: 284 FVHSENQHLVSPEALDFLDKLLRY 307
            +   +   +SP+A+ F+ ++LR 
Sbjct: 317 SLQKCHNLSISPQAIPFILRMLRI 340


>4FLV-A nrPDB
          Length = 793

 Score = 28.8 bits (63), Expect = 4.1,   Method: Composition-based stats.
 Identities = 14/32 (43%), Positives = 18/32 (56%)

Query: 51  SEVFEAINITNNEKVVVKILKPVKKKKIKREI 82
           ++V EAI    N    VKI+K V +K  K EI
Sbjct: 646 AKVLEAILKHGNVDEAVKIVKEVTEKLSKYEI 677


>6GL3-A nrPDB
          Length = 386

 Score = 28.4 bits (62), Expect = 4.8,   Method: Composition-based stats.
 Identities = 5/19 (26%), Positives = 11/19 (57%), Gaps = 1/19 (5%)

Query: 160 HNVMIDHEHRKLRLIDWGL 178
            N+++D E   + + D+G 
Sbjct: 263 GNILLDAEGHIIHI-DFGF 280


>3TSR-E nrPDB
          Length = 457

 Score = 28.4 bits (62), Expect = 4.9,   Method: Composition-based stats.
 Identities = 13/56 (23%), Positives = 26/56 (46%), Gaps = 1/56 (1%)

Query: 77  KIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNT-DFKQLYQTLTDY 131
           +  RE+ +  N  GGP ++ L + +K P      LV   +  T + ++  + L + 
Sbjct: 394 RSLRELDLSNNCMGGPGVLQLLESLKQPSCTLQQLVLYDIYWTNEVEEQLRALEEE 449


>5C4G-E nrPDB
          Length = 529

 Score = 28.4 bits (62), Expect = 5.2,   Method: Composition-based stats.
 Identities = 5/19 (26%), Positives = 11/19 (57%), Gaps = 1/19 (5%)

Query: 160 HNVMIDHEHRKLRLIDWGL 178
            N+++D E   + + D+G 
Sbjct: 405 GNILLDAEGHIIHI-DFGF 422


>4D0L-A nrPDB
          Length = 566

 Score = 28.4 bits (62), Expect = 5.2,   Method: Composition-based stats.
 Identities = 5/19 (26%), Positives = 11/19 (57%), Gaps = 1/19 (5%)

Query: 160 HNVMIDHEHRKLRLIDWGL 178
            N+++D E   + + D+G 
Sbjct: 442 GNILLDAEGHIIHI-DFGF 459


>6HXI-B nrPDB
          Length = 631

 Score = 28.4 bits (62), Expect = 5.3,   Method: Composition-based stats.
 Identities = 14/78 (17%), Positives = 25/78 (32%), Gaps = 1/78 (1%)

Query: 227 FRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVH 286
             +E  + G    D L R   + G   L  +  K   E    F +++ +           
Sbjct: 363 SGEELLYAGKKLSDVLDRKMGIGGVIGLL-WFKKELPEYAAHFIELVIQIVADHGPAVSG 421

Query: 287 SENQHLVSPEALDFLDKL 304
           + N  + S    D +  L
Sbjct: 422 AHNAIVASCAGKDLISSL 439


  Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta
    Posted date:  Jan 3, 2023  9:05 PM
  Number of letters in database: 10,336,785
  Number of sequences in database:  36,641
  
Lambda     K      H
   0.308    0.140    0.423 

Lambda     K      H
   0.267   0.0431    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,975,025
Number of Sequences: 36641
Number of extensions: 762673
Number of successful extensions: 6607
Number of sequences better than 10.0: 517
Number of HSP's better than 10.0 without gapping: 819
Number of HSP's successfully gapped in prelim test: 157
Number of HSP's that attempted gapping in prelim test: 2320
Number of HSP's gapped (non-prelim): 1390
length of query: 391
length of database: 10,336,785
effective HSP length: 99
effective length of query: 292
effective length of database: 6,709,326
effective search space: 1959123192
effective search space used: 1959123192
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.1 bits)
S2: 60 (27.6 bits)