BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P68400 (391 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 4MD7-E nrPDB 808 0.0 6EII-A nrPDB 683 0.0 6HMD-A nrPDB 563 e-161 2PVN-A nrPDB 494 e-140 6O6Q-A nrPDB 460 e-130 5XVU-A nrPDB 422 e-118 4LFI-A nrPDB 387 e-108 5Z33-A nrPDB 160 8e-40 4E7W-A nrPDB 158 4e-39 3OHT-A nrPDB 143 2e-34 3NIZ-A nrPDB 142 3e-34 4MYG-A nrPDB 141 4e-34 3GC9-A nrPDB 141 6e-34 1V0B-A nrPDB 140 1e-33 2BPM-A nrPDB 140 1e-33 1CM8-A nrPDB 140 1e-33 5AIR-A nrPDB 139 3e-33 6GU6-A nrPDB 139 3e-33 4EWQ-A nrPDB 137 6e-33 4KRC-A nrPDB 136 2e-32 1UA2-A nrPDB 135 3e-32 5NGU-A nrPDB 133 2e-31 4QNY-A nrPDB 132 2e-31 2F9G-A nrPDB 131 4e-31 4AU8-A nrPDB 131 4e-31 4QTB-A nrPDB 131 4e-31 3EB0-A nrPDB 131 5e-31 3OZ6-A nrPDB 130 7e-31 6DTL-A nrPDB 130 1e-30 1G3N-A nrPDB 128 5e-30 4AGU-A nrPDB 126 1e-29 3GC0-A nrPDB 124 6e-29 4IC8-A nrPDB 124 7e-29 5G6V-A nrPDB 123 2e-28 5EFQ-A nrPDB 122 2e-28 4ZSG-A nrPDB 121 5e-28 3E3P-A nrPDB 118 5e-27 4NST-A nrPDB 117 9e-27 3PG1-A nrPDB 117 9e-27 4BBM-A nrPDB 117 1e-26 4BGQ-A nrPDB 116 2e-26 2I6L-A nrPDB 114 9e-26 3MIA-A nrPDB 114 1e-25 3NIE-A nrPDB 110 2e-24 3RP9-A nrPDB 109 2e-24 5Y86-A nrPDB 108 5e-24 4O2Z-A nrPDB 107 1e-23 2W96-B nrPDB 105 2e-23 3ZDU-A nrPDB 104 7e-23 5ZTN-A nrPDB 103 1e-22 3MN3-A nrPDB 103 2e-22 3E7O-A nrPDB 102 3e-22 2X4F-A nrPDB 101 6e-22 5JN2-A nrPDB 100 1e-21 3N9X-A nrPDB 100 2e-21 1JNK-A nrPDB 99 3e-21 3MA6-A nrPDB 99 4e-21 4NIF-A nrPDB 98 5e-21 4CRL-A nrPDB 98 6e-21 3FI2-A nrPDB 97 8e-21 2XS0-A nrPDB 97 8e-21 5AWM-A nrPDB 97 1e-20 2J90-A nrPDB 97 2e-20 3LIJ-A nrPDB 96 3e-20 3NCG-A nrPDB 95 4e-20 3DFA-A nrPDB 95 5e-20 1KOB-A nrPDB 95 6e-20 3DXN-A nrPDB 94 7e-20 4MVF-A nrPDB 94 1e-19 4F9B-A nrPDB 93 2e-19 4YNZ-A nrPDB 93 2e-19 3HZT-A nrPDB 93 2e-19 6FDY-U nrPDB 92 3e-19 5ES1-A nrPDB 92 4e-19 4JG6-A nrPDB 92 6e-19 2Y7J-A nrPDB 91 7e-19 3KN6-A nrPDB 91 8e-19 3TAC-A nrPDB 91 9e-19 2YAB-A nrPDB 91 1e-18 2VN9-A nrPDB 89 3e-18 1ZWS-A nrPDB 89 3e-18 5YKS-A nrPDB 89 3e-18 4C0T-A nrPDB 89 4e-18 6QAU-A nrPDB 88 5e-18 5XZW-A nrPDB 88 6e-18 2HW6-A nrPDB 88 7e-18 3D2K-A nrPDB 88 7e-18 2VZ6-A nrPDB 87 8e-18 3F3Z-A nrPDB 87 9e-18 1TKI-A nrPDB 87 1e-17 5U6Y-A nrPDB 87 1e-17 2A27-A nrPDB 87 1e-17 2QNJ-A nrPDB 87 2e-17 4UZD-A nrPDB 87 2e-17 5UNP-A nrPDB 87 2e-17 2HAK-A nrPDB 86 2e-17 3Q5I-A nrPDB 86 2e-17 6CMJ-A nrPDB 86 2e-17 4FG9-A nrPDB 86 2e-17 3GUB-A nrPDB 86 2e-17 4CFF-A nrPDB 86 3e-17 4PDS-A nrPDB 86 3e-17 3ORZ-A nrPDB 86 3e-17 2WO6-A nrPDB 86 3e-17 3UTO-A nrPDB 86 3e-17 5EZV-A nrPDB 86 3e-17 5WAX-A nrPDB 86 4e-17 6C9D-A nrPDB 86 4e-17 1KOA-A nrPDB 85 4e-17 5KZ7-A nrPDB 85 7e-17 4YZB-A nrPDB 84 8e-17 5FG8-A nrPDB 84 8e-17 4CZT-A nrPDB 84 9e-17 3SOA-A nrPDB 84 1e-16 4RLP-A nrPDB 84 1e-16 3BHH-A nrPDB 84 1e-16 4L42-A nrPDB 84 1e-16 2BDW-A nrPDB 83 2e-16 2JC6-A nrPDB 83 2e-16 4RGJ-A nrPDB 83 2e-16 2YZA-A nrPDB 83 3e-16 4D2V-A nrPDB 82 3e-16 3RAW-A nrPDB 82 3e-16 3KK8-A nrPDB 82 4e-16 5X8I-B nrPDB 82 5e-16 4WNO-A nrPDB 82 5e-16 2W4O-A nrPDB 82 5e-16 3H4J-B nrPDB 82 5e-16 1PHK-A nrPDB 81 9e-16 5IG1-A nrPDB 80 1e-15 4I6B-A nrPDB 80 1e-15 5TUR-A nrPDB 80 1e-15 4REW-A nrPDB 80 1e-15 3A8W-A nrPDB 80 1e-15 5UUU-A nrPDB 80 2e-15 2WQN-A nrPDB 80 2e-15 1NY3-A nrPDB 79 3e-15 4CQG-A nrPDB 79 3e-15 2OZA-A nrPDB 79 3e-15 4B6L-A nrPDB 79 3e-15 3BGP-A nrPDB 79 3e-15 3PVW-A nrPDB 79 3e-15 4RC3-A nrPDB 79 4e-15 2V7O-A nrPDB 79 4e-15 4CFH-A nrPDB 79 4e-15 3KA0-A nrPDB 79 4e-15 5YV8-A nrPDB 79 4e-15 5D9K-A nrPDB 79 4e-15 2YCR-A nrPDB 79 5e-15 4JXF-A nrPDB 79 5e-15 4D28-A nrPDB 78 5e-15 2Z7Q-A nrPDB 78 5e-15 5JZN-A nrPDB 78 6e-15 6FD3-A nrPDB 78 7e-15 6FYV-A nrPDB 77 1e-14 3UC3-A nrPDB 77 1e-14 2BRG-A nrPDB 77 1e-14 4RED-A nrPDB 77 1e-14 3I6U-A nrPDB 76 3e-14 2JD5-A nrPDB 76 3e-14 1U5R-A nrPDB 76 3e-14 5J5T-A nrPDB 75 3e-14 4X7Q-B nrPDB 75 4e-14 3FXW-A nrPDB 75 4e-14 3ZUT-A nrPDB 75 5e-14 2GCD-A nrPDB 75 6e-14 3LM0-A nrPDB 75 7e-14 3HKO-A nrPDB 74 7e-14 2JAM-A nrPDB 74 8e-14 6CKI-A nrPDB 74 9e-14 3NYO-A nrPDB 74 9e-14 1VZO-A nrPDB 74 1e-13 3LLT-A nrPDB 74 1e-13 6ED6-A nrPDB 74 2e-13 3TXO-A nrPDB 73 2e-13 3HDN-A nrPDB 73 2e-13 3DB8-A nrPDB 73 2e-13 4B8L-A nrPDB 73 2e-13 5D7A-A nrPDB 73 3e-13 3DLS-A nrPDB 72 3e-13 3UDB-A nrPDB 72 4e-13 5F9E-A nrPDB 72 4e-13 4FIE-A nrPDB 72 5e-13 3Q53-A nrPDB 72 5e-13 6E9W-A nrPDB 72 6e-13 3ORP-A nrPDB 71 7e-13 3QA8-A nrPDB 71 7e-13 4TNB-A nrPDB 71 9e-13 4JDH-A nrPDB 70 1e-12 6HXF-B nrPDB 70 1e-12 1FOT-A nrPDB 70 1e-12 4AF3-A nrPDB 70 1e-12 4KIK-B nrPDB 70 2e-12 2Q0N-A nrPDB 70 2e-12 6DBM-A nrPDB 70 2e-12 2OU7-A nrPDB 70 2e-12 2JDO-A nrPDB 70 2e-12 4QMW-A nrPDB 69 2e-12 6CQF-A nrPDB 69 3e-12 4KS7-A nrPDB 69 3e-12 4J52-A nrPDB 69 3e-12 4OLI-A nrPDB 69 4e-12 6BDL-A nrPDB 69 5e-12 4XBR-A nrPDB 69 5e-12 4EQM-A nrPDB 68 6e-12 2XNP-A nrPDB 68 6e-12 3DAK-A nrPDB 67 1e-11 1ZXE-A nrPDB 67 1e-11 3M42-A nrPDB 67 1e-11 4NFN-A nrPDB 67 1e-11 4BTK-A nrPDB 67 1e-11 4WUA-A nrPDB 67 2e-11 3IS5-A nrPDB 66 2e-11 3PFQ-A nrPDB 66 3e-11 4U41-A nrPDB 66 3e-11 2I0E-A nrPDB 66 3e-11 5KCV-A nrPDB 65 4e-11 2UV2-A nrPDB 65 5e-11 5FET-A nrPDB 65 5e-11 3C51-A nrPDB 65 6e-11 5DYK-A nrPDB 65 6e-11 3MV5-A nrPDB 65 6e-11 3COM-A nrPDB 65 7e-11 6CCF-A nrPDB 64 8e-11 6DBN-A nrPDB 64 9e-11 5N23-A nrPDB 64 9e-11 4RA4-A nrPDB 64 1e-10 4AW2-A nrPDB 64 1e-10 4IAN-A nrPDB 64 1e-10 6E2O-A nrPDB 64 1e-10 4WB7-A nrPDB 64 1e-10 5FQD-C nrPDB 64 1e-10 4X3F-A nrPDB 64 1e-10 5TQX-A nrPDB 63 2e-10 5X3F-B nrPDB 63 2e-10 2WTK-C nrPDB 63 2e-10 4OW8-A nrPDB 63 3e-10 2XIK-A nrPDB 63 3e-10 6B2Q-A nrPDB 62 3e-10 4E20-A nrPDB 62 3e-10 2PMN-X nrPDB 62 3e-10 4C59-A nrPDB 62 4e-10 3VN9-A nrPDB 62 4e-10 2X7G-A nrPDB 62 4e-10 3OMV-A nrPDB 62 5e-10 5DBX-A nrPDB 62 5e-10 4LG4-A nrPDB 62 5e-10 2F57-A nrPDB 62 5e-10 5LOH-A nrPDB 62 5e-10 4YHJ-A nrPDB 61 7e-10 3TKU-A nrPDB 61 9e-10 4FR4-A nrPDB 61 9e-10 6AO5-A nrPDB 60 1e-09 4FZF-B nrPDB 60 1e-09 2DQ7-X nrPDB 60 1e-09 3FME-A nrPDB 59 3e-09 4E93-A nrPDB 59 3e-09 3ALO-A nrPDB 59 3e-09 4M66-A nrPDB 59 3e-09 6HV0-A nrPDB 59 4e-09 4PL5-B nrPDB 59 5e-09 4CSV-A nrPDB 59 5e-09 2PZI-A nrPDB 58 6e-09 4HVI-A nrPDB 58 6e-09 4Y12-A nrPDB 58 7e-09 6GVJ-A nrPDB 58 8e-09 5HI2-A nrPDB 58 9e-09 5H2U-A nrPDB 57 1e-08 4APC-A nrPDB 57 1e-08 5O2B-A nrPDB 57 1e-08 4IDT-A nrPDB 57 1e-08 5O2C-A nrPDB 57 1e-08 4H1J-A nrPDB 57 2e-08 2VD5-A nrPDB 56 2e-08 3HMP-A nrPDB 56 2e-08 2ZMD-A nrPDB 56 2e-08 3SV0-A nrPDB 56 2e-08 5X5O-A nrPDB 56 3e-08 4PWN-A nrPDB 56 3e-08 4XEY-B nrPDB 56 3e-08 5HIE-A nrPDB 56 3e-08 6BXI-A nrPDB 55 4e-08 5AP3-A nrPDB 55 4e-08 2H8H-A nrPDB 55 4e-08 6F3F-A nrPDB 55 4e-08 4G3E-A nrPDB 55 7e-08 2W1I-A nrPDB 55 7e-08 3IO7-A nrPDB 55 7e-08 3CJF-A nrPDB 55 7e-08 2FO0-A nrPDB 54 8e-08 4LQP-A nrPDB 54 8e-08 2BUJ-A nrPDB 54 9e-08 3BEA-A nrPDB 54 1e-07 6NPU-A nrPDB 54 1e-07 5O0Y-A nrPDB 54 1e-07 5KKR-C nrPDB 54 1e-07 3EQC-A nrPDB 53 2e-07 4AN9-A nrPDB 53 2e-07 6CTH-A nrPDB 53 2e-07 4M7I-A nrPDB 53 2e-07 5VD3-A nrPDB 53 2e-07 3A4O-X nrPDB 52 3e-07 3PLS-A nrPDB 52 4e-07 3PP0-A nrPDB 52 5e-07 2CMW-A nrPDB 52 5e-07 5HLW-A nrPDB 52 5e-07 5X02-A nrPDB 52 6e-07 2PL0-A nrPDB 52 6e-07 5TE0-A nrPDB 51 7e-07 5HVK-A nrPDB 51 7e-07 2C47-A nrPDB 51 8e-07 5A46-A nrPDB 51 8e-07 4XUF-A nrPDB 51 9e-07 3TT0-A nrPDB 51 1e-06 3GQL-A nrPDB 50 1e-06 5SYS-A nrPDB 50 1e-06 2XYN-A nrPDB 50 2e-06 4EBW-A nrPDB 50 2e-06 3KRL-A nrPDB 50 2e-06 5GRN-A nrPDB 50 2e-06 2A1A-B nrPDB 50 2e-06 2OGV-A nrPDB 50 2e-06 4TN6-A nrPDB 49 3e-06 6GQK-A nrPDB 49 4e-06 3MY0-A nrPDB 49 4e-06 5IKW-A nrPDB 49 4e-06 1S9I-A nrPDB 49 4e-06 3UIU-A nrPDB 49 4e-06 2CHL-A nrPDB 49 5e-06 2HK5-A nrPDB 49 5e-06 4TPT-A nrPDB 48 6e-06 3DTC-A nrPDB 48 6e-06 3PPZ-A nrPDB 48 7e-06 4UYA-A nrPDB 48 7e-06 2J0K-A nrPDB 48 8e-06 5B2L-A nrPDB 48 8e-06 4UY9-A nrPDB 47 1e-05 4K33-A nrPDB 47 1e-05 4EUU-A nrPDB 47 1e-05 3C1X-A nrPDB 47 1e-05 3G0E-A nrPDB 47 1e-05 4EUT-A nrPDB 47 2e-05 4OTD-A nrPDB 47 2e-05 5M07-A nrPDB 47 2e-05 5AMN-A nrPDB 46 2e-05 4GS6-A nrPDB 46 2e-05 4R7H-A nrPDB 46 2e-05 4JLC-A nrPDB 46 2e-05 5FM2-A nrPDB 46 2e-05 1AD5-A nrPDB 46 4e-05 6NT9-A nrPDB 45 4e-05 2H34-A nrPDB 45 4e-05 4RT7-A nrPDB 45 4e-05 3MDY-A nrPDB 45 5e-05 1CSN-A nrPDB 45 5e-05 4NT4-A nrPDB 45 5e-05 5CEK-A nrPDB 45 5e-05 6O8B-A nrPDB 45 5e-05 2RIO-A nrPDB 45 6e-05 2PSQ-A nrPDB 45 6e-05 4NEU-A nrPDB 45 7e-05 5WNL-A nrPDB 45 8e-05 5EG3-A nrPDB 45 8e-05 5L2Q-C nrPDB 44 8e-05 4P5Q-A nrPDB 44 8e-05 4AT3-A nrPDB 44 1e-04 6DC0-A nrPDB 44 1e-04 2VWV-A nrPDB 44 1e-04 5AR8-A nrPDB 44 1e-04 3QUP-A nrPDB 44 1e-04 4CRS-A nrPDB 44 2e-04 5U6B-A nrPDB 44 2e-04 2WTK-B nrPDB 44 2e-04 4LRM-A nrPDB 44 2e-04 4Y83-A nrPDB 43 2e-04 3KUL-B nrPDB 43 2e-04 4XLV-A nrPDB 43 2e-04 4XCU-A nrPDB 43 2e-04 3HNG-A nrPDB 43 3e-04 2R2P-A nrPDB 42 4e-04 5X18-A nrPDB 42 4e-04 1FVR-A nrPDB 42 5e-04 3VHK-A nrPDB 42 6e-04 3QD2-B nrPDB 42 6e-04 4XHH-A nrPDB 41 7e-04 3BBT-B nrPDB 41 8e-04 2QLU-A nrPDB 41 8e-04 3ZZW-A nrPDB 41 0.001 4XHL-A nrPDB 41 0.001 3LZB-A nrPDB 40 0.001 4IX6-A nrPDB 40 0.001 5GNK-A nrPDB 40 0.001 4CI6-B nrPDB 40 0.002 3DKO-A nrPDB 40 0.002 1JPA-A nrPDB 39 0.003 4JRN-A nrPDB 39 0.003 4YFF-A nrPDB 39 0.003 5DMZ-A nrPDB 39 0.003 3V5Q-A nrPDB 39 0.003 5VO2-A nrPDB 39 0.003 4XI2-A nrPDB 39 0.004 6E4F-A nrPDB 39 0.004 5MJB-A nrPDB 39 0.004 3SOC-A nrPDB 39 0.005 1LUF-A nrPDB 39 0.006 4Y93-A nrPDB 37 0.011 5U6C-A nrPDB 37 0.014 5L6P-A nrPDB 37 0.017 2Y6O-A nrPDB 37 0.017 2QKW-B nrPDB 37 0.017 2OZO-A nrPDB 37 0.017 5WNO-A nrPDB 37 0.017 1U59-A nrPDB 37 0.017 2Y4I-B nrPDB 37 0.019 5CLR-A nrPDB 36 0.024 1BYG-A nrPDB 36 0.024 1K9A-A nrPDB 36 0.028 4PDO-A nrPDB 36 0.029 3G2F-A nrPDB 35 0.051 3BIQ-A nrPDB 35 0.054 3ZBF-A nrPDB 34 0.089 4FL3-A nrPDB 34 0.097 5TOS-A nrPDB 34 0.12 4AZV-A nrPDB 33 0.15 3UIM-A nrPDB 33 0.16 5C26-A nrPDB 33 0.18 4AZW-A nrPDB 33 0.18 2RSV-A nrPDB 33 0.22 4O1O-A nrPDB 33 0.24 5VC6-A nrPDB 33 0.25 6G4J-A nrPDB 33 0.25 2LAV-A nrPDB 33 0.26 5XD6-A nrPDB 32 0.33 6BFN-A nrPDB 32 0.54 3SXS-A nrPDB 32 0.61 5UIU-A nrPDB 31 1.1 3LMG-A nrPDB 30 1.2 5LPZ-A nrPDB 30 1.4 3JB4-B nrPDB 30 1.4 6J6I-B nrPDB 30 1.6 5VDK-A nrPDB 30 1.6 5LPV-A nrPDB 30 1.8 1JKF-A nrPDB 30 2.5 4V1O-Q nrPDB 29 3.2 4OAU-C nrPDB 29 4.0 5UU1-A nrPDB 28 5.0 3LY6-A nrPDB 28 5.3 4W6Q-A nrPDB 28 5.4 5OAT-A nrPDB 28 5.6 >4MD7-E nrPDB Length = 391 Score = 808 bits (2086), Expect = 0.0, Method: Compositional matrix adjust. Identities = 387/391 (98%), Positives = 387/391 (98%) Query: 1 MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINIT 60 MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINIT Sbjct: 1 MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINIT 60 Query: 61 NNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTD 120 NNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTD Sbjct: 61 NNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTD 120 Query: 121 FKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE 180 FKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE Sbjct: 121 FKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE 180 Query: 181 FYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYD 240 FYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYD Sbjct: 181 FYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYD 240 Query: 241 QLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDF 300 QLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDF Sbjct: 241 QLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDF 300 Query: 301 LDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPT 360 LDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGS PVSSANMMSGISSVP Sbjct: 301 LDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSEPVSSANMMSGISSVPE 360 Query: 361 PSPLGPLAGSPVIAAANPLGMPVPAAAGAQQ 391 P PLGPLAG PVIAAANPLGMPVPAAAGAQQ Sbjct: 361 PEPLGPLAGEPVIAAANPLGMPVPAAAGAQQ 391 >6EII-A nrPDB Length = 352 Score = 683 bits (1763), Expect = 0.0, Method: Compositional matrix adjust. Identities = 327/328 (99%), Positives = 327/328 (99%) Query: 2 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITN 61 SGPVPSRARVYTDVNTHRP EYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITN Sbjct: 25 SGPVPSRARVYTDVNTHRPSEYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITN 84 Query: 62 NEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDF 121 NEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDF Sbjct: 85 NEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDF 144 Query: 122 KQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF 181 KQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF Sbjct: 145 KQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF 204 Query: 182 YHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQ 241 YHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQ Sbjct: 205 YHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQ 264 Query: 242 LVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFL 301 LVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFL Sbjct: 265 LVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFL 324 Query: 302 DKLLRYDHQSRLTAREAMEHPYFYTVVK 329 DKLLRYDHQSRLTAREAMEHPYFYTVVK Sbjct: 325 DKLLRYDHQSRLTAREAMEHPYFYTVVK 352 >6HMD-A nrPDB Length = 365 Score = 563 bits (1452), Expect = e-161, Method: Compositional matrix adjust. Identities = 289/355 (81%), Positives = 314/355 (88%), Gaps = 7/355 (1%) Query: 1 MSGPVP-SRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINI 59 M GP SRARVY +VN+ R REYWDYE+HV WGNQDDYQLVRKLGRGKYSEVFEAINI Sbjct: 16 MPGPAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINI 75 Query: 60 TNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNT 119 TNNE+VVVKILKPVKKKKIKRE+KILENLRGG NII L D VKDPVS+TPALVFE++NNT Sbjct: 76 TNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNT 135 Query: 120 DFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA 179 DFKQLYQ LTD+DIRFYMYE+LKALDYCHS GIMHRDVKPHNVMIDH+ +KLRLIDWGLA Sbjct: 136 DFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLA 195 Query: 180 EFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNY 239 EFYHP QEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFR+EPFFHG DNY Sbjct: 196 EFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNY 255 Query: 240 DQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALD 299 DQLVRIAKVLGTE+LY Y+ KY+I+LDP FNDILG+HSRKRWE F+HSEN+HLVSPEALD Sbjct: 256 DQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALD 315 Query: 300 FLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSG 354 LDKLLRYDHQ RLTA+EAMEHPYFY VVK+Q S P V S+ + + Sbjct: 316 LLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQ------SQPSADNAVLSSGLTAA 364 >2PVN-A nrPDB Length = 352 Score = 494 bits (1272), Expect = e-140, Method: Compositional matrix adjust. Identities = 250/325 (76%), Positives = 286/325 (88%) Query: 3 GPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNN 62 G S+ARVY DVN RP+EYWDYE+ V+WG QDDY++VRK+GRGKYSEVFE IN+ NN Sbjct: 18 GSHMSKARVYADVNVLRPKEYWDYEALTVQWGEQDDYEVVRKVGRGKYSEVFEGINVNNN 77 Query: 63 EKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFK 122 EK ++KILKPVKKKKIKREIKIL+NL GGPNI+ L DIV+D S+TP+L+FE+VNNTDFK Sbjct: 78 EKCIIKILKPVKKKKIKREIKILQNLCGGPNIVKLLDIVRDQHSKTPSLIFEYVNNTDFK 137 Query: 123 QLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFY 182 LY TLTDYDIR+Y+YE+LKALDYCHS GIMHRDVKPHNVMIDHE RKLRLIDWGLAEFY Sbjct: 138 VLYPTLTDYDIRYYIYELLKALDYCHSQGIMHRDVKPHNVMIDHELRKLRLIDWGLAEFY 197 Query: 183 HPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQL 242 HPG+EYNVRVASRYFKGPELLVD Q YDYSLDMWSLGCM A MIFRKEPFF+GHDN+DQL Sbjct: 198 HPGKEYNVRVASRYFKGPELLVDLQDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQL 257 Query: 243 VRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLD 302 V+IAKVLGT+ L Y++KY IELDP+ ++GRHSRK W +F++++NQHLVSPEA+DFLD Sbjct: 258 VKIAKVLGTDGLNAYLNKYRIELDPQLEALVGRHSRKPWLKFMNADNQHLVSPEAIDFLD 317 Query: 303 KLLRYDHQSRLTAREAMEHPYFYTV 327 KLLRYDHQ RLTA EAM HPYF V Sbjct: 318 KLLRYDHQERLTALEAMTHPYFQQV 342 >6O6Q-A nrPDB Length = 335 Score = 460 bits (1183), Expect = e-130, Method: Compositional matrix adjust. Identities = 211/320 (65%), Positives = 264/320 (82%), Gaps = 1/320 (0%) Query: 5 VPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEK 64 V S +RVY DV + +P+ YWDY+ ++W Q++Y+++RKLGRGKYSEVF I++ EK Sbjct: 9 VQSVSRVYADVLSTKPQSYWDYDDLNIKWNPQENYEILRKLGRGKYSEVFLGIDLEKREK 68 Query: 65 VVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQL 124 VV+K+LKPVK+KKIKREI IL+NL GPNII + D+V++P S+TP L+FEH+NN DF+ L Sbjct: 69 VVIKVLKPVKRKKIKREISILKNLVDGPNIIAMLDVVREPQSKTPGLIFEHINNIDFRSL 128 Query: 125 YQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHP 184 Y T TDYDIRFYMYE+LKALDY HSMGIMHRDVKPHNVMIDH+ + LRLIDWGLAE+YHP Sbjct: 129 YPTFTDYDIRFYMYELLKALDYSHSMGIMHRDVKPHNVMIDHDKKLLRLIDWGLAEYYHP 188 Query: 185 GQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVR 244 G EYNVRVASRYFKGPELLVDY++YDYSLDMWS GCMLASM+F KEPFFHG N DQLV+ Sbjct: 189 GTEYNVRVASRYFKGPELLVDYRLYDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQLVQ 248 Query: 245 IAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKL 304 I +VLG+++ Y++KYNI L + DI G +++++W RF++ N+ LVS E LD +D+L Sbjct: 249 IVRVLGSKNFKKYLEKYNISLGEEYEDI-GYYNKRQWVRFMNENNKDLVSQEFLDLIDRL 307 Query: 305 LRYDHQSRLTAREAMEHPYF 324 LRYDHQ RLTA+EAM+H YF Sbjct: 308 LRYDHQERLTAKEAMKHAYF 327 >5XVU-A nrPDB Length = 332 Score = 422 bits (1085), Expect = e-118, Method: Compositional matrix adjust. Identities = 209/323 (64%), Positives = 261/323 (80%) Query: 10 RVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKI 69 + Y DVN H+P+EY+DY++ ++W + Y++++K+GRGKYSEVF + N +K+ Sbjct: 4 KFYADVNIHKPKEYYDYDNLELQWNKPNRYEIMKKIGRGKYSEVFNGYDTECNRPCAIKV 63 Query: 70 LKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLT 129 LKPVKKKKIKREIKIL+NL GGPNII L DIVKDPV++TP+L+FE++NN DFK LY T Sbjct: 64 LKPVKKKKIKREIKILQNLNGGPNIIKLLDIVKDPVTKTPSLIFEYINNIDFKTLYPKFT 123 Query: 130 DYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYN 189 D DIR+Y+Y+ILKALDYCHS GIMHRDVKPHN+MIDHE+R++RLI WGLAEFYHPGQEYN Sbjct: 124 DKDIRYYIYQILKALDYCHSQGIMHRDVKPHNIMIDHENRQIRLISWGLAEFYHPGQEYN 183 Query: 190 VRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVL 249 VRVASRY+KGPELL+D Q+YDYSLD+WSLGCMLA MIF+KEPFF GHDNYDQLV+IAKVL Sbjct: 184 VRVASRYYKGPELLIDLQLYDYSLDIWSLGCMLAGMIFKKEPFFCGHDNYDQLVKIAKVL 243 Query: 250 GTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDH 309 GTEDL+ Y+ KYNI+L P + +ILG + RK W F+ N + E +D +DK+L YDH Sbjct: 244 GTEDLHAYLKKYNIKLKPHYLNILGEYERKPWSHFLTQSNIDIAKDEVIDLIDKMLIYDH 303 Query: 310 QSRLTAREAMEHPYFYTVVKDQA 332 R+ +EAMEHPYF V ++ A Sbjct: 304 AKRIAPKEAMEHPYFREVREESA 326 >4LFI-A nrPDB Length = 374 Score = 387 bits (994), Expect = e-108, Method: Compositional matrix adjust. Identities = 200/364 (54%), Positives = 253/364 (69%), Gaps = 41/364 (11%) Query: 1 MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWG-NQDDYQLVRKLGRGKYSEVFEAINI 59 M V S ARVYT++N R EYWDYE+ V++W N DY++ K+GRGKYSEVF+ + + Sbjct: 3 MKCRVWSEARVYTNINKQRTEEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKL 62 Query: 60 TNNEKVVVKI---------------LKPVKKKKI--------------KREIKILENLR- 89 + K+V+K+ L + +K+ ++ +L+ +R Sbjct: 63 DSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRP 122 Query: 90 --------GGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEIL 141 G NII L DI+KDP+S+TPALVFE+V+N DF+ LY LTD +IRFYM+E+L Sbjct: 123 YIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPKLTDLEIRFYMFELL 182 Query: 142 KALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPE 201 KALDYCHSMGIMHRDVKPHNVMIDH+++KLRLIDWGLAEFYH EYNVRVASR+FKGPE Sbjct: 183 KALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPE 242 Query: 202 LLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKY 261 LLVDY+MYDYSLD+WS G MLASMIF++EPFFHG N DQLV+I KVLGT D Y+ KY Sbjct: 243 LLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKY 302 Query: 262 NIELDPRFNDILGRHSRKRWERFVHSENQHLV-SPEALDFLDKLLRYDHQSRLTAREAME 320 I L F D + ++ RK W RF++ N+HL + E +D +D LLRYDHQ RLTA+EAM Sbjct: 303 EITLPREFYD-MDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMG 361 Query: 321 HPYF 324 HP+F Sbjct: 362 HPWF 365 >5Z33-A nrPDB Length = 425 Score = 160 bits (405), Expect = 8e-40, Method: Compositional matrix adjust. Identities = 97/301 (32%), Positives = 168/301 (55%), Gaps = 22/301 (7%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIK-----REIKILENLRGGPN 93 Y + ++LG+G Y V A+N +E V +K + V KKI REIK+L++ RG N Sbjct: 33 YTVTKELGQGAYGIVCAAVNNQTSEGVAIKKVTNVFSKKILAKRALREIKLLQHFRGHRN 92 Query: 94 IITLADI-VKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCHS 149 I L D+ + P + ++E + D + Q LTD + ++Y+IL L Y HS Sbjct: 93 ITCLYDMDIPRPDNFNETYLYEELMECDLAAIIRSGQPLTDAHFQSFIYQILCGLKYIHS 152 Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVR-----VASRYFKGPELLV 204 ++HRD+KP N++++ + +L++ D+GLA + E N VA+R+++ PE+++ Sbjct: 153 ANVLHRDLKPGNLLVNADC-ELKICDFGLARGFSVDPEENAGYMTEYVATRWYRAPEIML 211 Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIE 264 +Q Y ++D+WS+GC+LA ++ + PFF G D DQL +I +LGT + + + + Sbjct: 212 SFQSYTKAIDVWSVGCILAELLGGR-PFFKGRDYVDQLNQILHILGTPN-EETLSRIGSP 269 Query: 265 LDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 + L ++K + + N P+ALD LD++L +D SR++ +A+EHPY Sbjct: 270 RAQEYVRNLPFMAKKPFPTLFPNAN-----PDALDLLDRMLAFDPSSRISVEQALEHPYL 324 Query: 325 Y 325 + Sbjct: 325 H 325 >4E7W-A nrPDB Length = 394 Score = 158 bits (400), Expect = 4e-39, Method: Compositional matrix adjust. Identities = 104/317 (32%), Positives = 169/317 (53%), Gaps = 33/317 (10%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLA 98 Y + +G G + VF+A + ++E + K+L+ K+ RE++I+ ++ PN++ L Sbjct: 42 YTNCKVIGNGSFGVVFQAKLVESDEVAIKKVLQ--DKRFKNRELQIMRIVKH-PNVVDLK 98 Query: 99 DIV------KDPVSRTPALVFEHVNNTDFK------QLYQTLTDYDIRFYMYEILKALDY 146 KD V LV E+V T ++ +L QT+ I+ YMY++L++L Y Sbjct: 99 AFFYSNGDKKDEVFLN--LVLEYVPETVYRASRHYAKLKQTMPMLLIKLYMYQLLRSLAY 156 Query: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDY 206 HS+GI HRD+KP N+++D L+LID+G A+ G+ + SRY++ PEL+ Sbjct: 157 IHSIGICHRDIKPQNLLLDPPSGVLKLIDFGSAKILIAGEPNVSYICSRYYRAPELIFGA 216 Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIE-L 265 Y ++D+WS GC++A ++ + +P F G DQLV I KVLGT + I N + Sbjct: 217 TNYTTNIDIWSTGCVMAELM-QGQPLFPGESGIDQLVEIIKVLGTPS-REQIKTMNPNYM 274 Query: 266 DPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFY 325 + +F I K + + P+A+D + +LL Y +RLTA EA+ HP+F Sbjct: 275 EHKFPQIRPHPFSKVF--------RPRTPPDAIDLISRLLEYTPSARLTAIEALCHPFF- 325 Query: 326 TVVKDQARMGSSSMPGG 342 D+ R G + MP G Sbjct: 326 ----DELRTGEARMPNG 338 >3OHT-A nrPDB Length = 389 Score = 143 bits (360), Expect = 2e-34, Method: Compositional matrix adjust. Identities = 99/334 (29%), Positives = 176/334 (52%), Gaps = 34/334 (10%) Query: 7 SRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVV 66 S A +T + RP ++ E + W + YQ + +G G Y V + ++ + K+ Sbjct: 22 SAAAPFTMSHKERPT-FYRQELNKTIWEVPERYQTLSPVGSGAYGSVCSSYDVKSGLKIA 80 Query: 67 VKIL-KP----VKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNN--- 118 VK L +P + K+ RE+++L++++ N+I L D+ TPA E N+ Sbjct: 81 VKKLSRPFQSIIHAKRTYRELRLLKHMKH-ENVIGLLDVF------TPATSLEEFNDVYL 133 Query: 119 ------TDFKQL--YQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRK 170 D + Q LTD ++F +Y+IL+ L Y HS I+HRD+KP N+ ++ E + Sbjct: 134 VTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCE 192 Query: 171 LRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKE 230 L+++D+GLA H E VA+R+++ PE+++++ Y+ ++D+WS+GC++A ++ + Sbjct: 193 LKILDFGLAR--HTDDEMTGYVATRWYRAPEIMLNWMHYNMTVDIWSVGCIMAELLTGRT 250 Query: 231 PFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQ 290 F G D+ +QL +I ++ GT + E N + R + F+ + Sbjct: 251 -LFPGTDHINQLQQIMRLTGTPPASVISRMPSHEARNYINSLPQMPKRNFADVFIGA--- 306 Query: 291 HLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 +P A+D L+K+L D R+TA EA+ HPYF Sbjct: 307 ---NPLAVDLLEKMLVLDTDKRITASEALAHPYF 337 >3NIZ-A nrPDB Length = 311 Score = 142 bits (357), Expect = 3e-34, Method: Compositional matrix adjust. Identities = 95/300 (31%), Positives = 158/300 (52%), Gaps = 22/300 (7%) Query: 34 GNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIK----REIKILENLR 89 G + YQ + K+G G Y V++A + + +I + + I REI +L+ L Sbjct: 18 GLMEKYQKLEKVGEGTYGVVYKAKDSQGRIVALKRIRLDAEDEGIPSTAIREISLLKELH 77 Query: 90 GGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----LTDYDIRFYMYEILKALD 145 PNI++L D++ R LVFE + D K++ L D I+ Y+Y++L+ + Sbjct: 78 H-PNIVSLIDVIHS--ERCLTLVFEFMEK-DLKKVLDENKTGLQDSQIKIYLYQLLRGVA 133 Query: 146 YCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE-FYHPGQEYNVRVASRYFKGPELLV 204 +CH I+HRD+KP N++I+ + L+L D+GLA F P + Y V + +++ P++L+ Sbjct: 134 HCHQHRILHRDLKPQNLLINSDG-ALKLADFGLARAFGIPVRSYTHEVVTLWYRAPDVLM 192 Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIE 264 + Y S+D+WS+GC+ A MI K P F G + DQL +I +LGT + ++ + Sbjct: 193 GSKKYSTSVDIWSIGCIFAEMITGK-PLFPGVTDDDQLPKIFSILGTPNPREWPQVQELP 251 Query: 265 LDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 L + +K W + Q E +D L +L +D R++AR+AM HPYF Sbjct: 252 LWKQRT--FQVFEKKPWSSIIPGFCQ-----EGIDLLSNMLCFDPNKRISARDAMNHPYF 304 >4MYG-A nrPDB Length = 372 Score = 141 bits (356), Expect = 4e-34, Method: Compositional matrix adjust. Identities = 95/315 (30%), Positives = 167/315 (53%), Gaps = 20/315 (6%) Query: 19 RPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL-KPVKK-- 75 R + ++ + + W Y +G G Y V AI+ + EKV +K L +P + Sbjct: 25 RKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEI 84 Query: 76 --KKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVN---NTDFKQLY-QTLT 129 K+ RE+ +L++++ N+I L D+ S F V TD +++ + Sbjct: 85 FAKRAYRELLLLKHMQH-ENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFS 143 Query: 130 DYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYN 189 + I++ +Y++LK L Y HS G++HRD+KP N+ ++ E +L+++D+GLA H E Sbjct: 144 EEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVN-EDCELKILDFGLAR--HADAEMT 200 Query: 190 VRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVL 249 V +R+++ PE+++ + Y+ ++D+WS+GC++A M+ K F G D DQL +I KV Sbjct: 201 GYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGK-TLFKGKDYLDQLTQILKVT 259 Query: 250 GTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDH 309 G +++ K N + + L + RK + + SP+A D L+K+L D Sbjct: 260 GVPGT-EFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPR-----ASPQAADLLEKMLELDV 313 Query: 310 QSRLTAREAMEHPYF 324 RLTA +A+ HP+F Sbjct: 314 DKRLTAAQALTHPFF 328 >3GC9-A nrPDB Length = 370 Score = 141 bits (355), Expect = 6e-34, Method: Compositional matrix adjust. Identities = 97/313 (30%), Positives = 164/313 (52%), Gaps = 43/313 (13%) Query: 33 WGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL-KP----VKKKKIKREIKILEN 87 W Q +R +G G Y V A + +KV VK L +P + ++ RE+++L++ Sbjct: 24 WEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKH 83 Query: 88 LRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY----------------QTLTDY 131 L+ N+I L D+ TPA E DF ++Y Q L+D Sbjct: 84 LKH-ENVIGLLDVF------TPATSIE-----DFSEVYLVTTLMGADLNNIVKSQALSDE 131 Query: 132 DIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVR 191 ++F +Y++L+ L Y HS GI+HRD+KP NV ++ E +LR++D+GLA +E Sbjct: 132 HVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVN-EDSELRILDFGLAR--QADEEMTGY 188 Query: 192 VASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGT 251 VA+R+++ PE+++++ Y+ ++D+WS+GC++A ++ + + F G D DQL RI +V+GT Sbjct: 189 VATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELL-QGKALFPGSDYIDQLKRIMEVVGT 247 Query: 252 EDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQS 311 + + K + E + L +K N P A+D L ++L D Sbjct: 248 PS-PEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGAN-----PLAIDLLGRMLVLDSDQ 301 Query: 312 RLTAREAMEHPYF 324 R++A EA+ H YF Sbjct: 302 RVSAAEALAHAYF 314 >1V0B-A nrPDB Length = 288 Score = 140 bits (353), Expect = 1e-33, Method: Compositional matrix adjust. Identities = 90/298 (30%), Positives = 162/298 (54%), Gaps = 25/298 (8%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK-----IKREIKILENLRGG 91 + Y + K+G G Y V++A N E +K ++ K+ + REI IL+ L+ Sbjct: 2 EKYHGLEKIGEGTYGVVYKAQN-NYGETFALKKIRLEKEDEGIPSTTIREISILKELKHS 60 Query: 92 PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----LTDYDIRFYMYEILKALDYC 147 NI+ L D++ + LVFEH++ D K+L L + ++ ++L + YC Sbjct: 61 -NIVKLYDVIH--TKKRLVLVFEHLDQ-DLKKLLDVCEGGLESVTAKSFLLQLLNGIAYC 116 Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE-FYHPGQEYNVRVASRYFKGPELLVDY 206 H ++HRD+KP N++I+ E +L++ D+GLA F P ++Y V + +++ P++L+ Sbjct: 117 HDRRVLHRDLKPQNLLINREG-ELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVLMGS 175 Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 266 + Y ++D+WS+GC+ A M+ P F G DQL+RI ++LGT + ++ N+ Sbjct: 176 KKYSTTIDIWSVGCIFAEMV-NGAPLFPGVSEADQLMRIFRILGTPNSKNWP---NVTEL 231 Query: 267 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 P+++ + WE F+ ++ +D L K+L+ D R+TA++A+EH YF Sbjct: 232 PKYDPNFTVYEPLPWESFLKGLDE-----SGIDLLSKMLKLDPNQRITAKQALEHAYF 284 >2BPM-A nrPDB Length = 309 Score = 140 bits (352), Expect = 1e-33, Method: Compositional matrix adjust. Identities = 95/307 (30%), Positives = 163/307 (53%), Gaps = 27/307 (8%) Query: 35 NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK------PVKKKKIKREIKILENL 88 + +++Q V K+G G Y V++A N E V +K ++ V I REI +L+ L Sbjct: 5 DMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAI-REISLLKEL 63 Query: 89 RGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY--QTLTDYD---IRFYMYEILKA 143 PNI+ L D++ LVFE ++ D K+ LT I+ Y++++L+ Sbjct: 64 -NHPNIVKLLDVIH--TENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQG 119 Query: 144 LDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE-FYHPGQEYNVRVASRYFKGPEL 202 L +CHS ++HRD+KP N++I+ E ++L D+GLA F P + Y V + +++ PE+ Sbjct: 120 LAFCHSHRVLHRDLKPQNLLINTEG-AIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEI 178 Query: 203 LVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYN 262 L+ + Y ++D+WSLGC+ A M+ R+ F G DQL RI + LGT D + + Sbjct: 179 LLGCKYYSTAVDIWSLGCIFAEMVTRRA-LFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS 237 Query: 263 IELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHP 322 + P + + +R+ + + V ++ + L ++L YD R++A+ A+ HP Sbjct: 238 M---PDYKPSFPKWARQDFSKVVPPLDE-----DGRSLLSQMLHYDPNKRISAKAALAHP 289 Query: 323 YFYTVVK 329 +F V K Sbjct: 290 FFQDVTK 296 >1CM8-A nrPDB Length = 367 Score = 140 bits (352), Expect = 1e-33, Method: Compositional matrix adjust. Identities = 100/343 (29%), Positives = 177/343 (51%), Gaps = 45/343 (13%) Query: 1 MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINIT 60 MS P P+R+ Y E W + Y+ ++ +G G Y V A++ Sbjct: 1 MSSPPPARSGFYRQ------------EVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGR 48 Query: 61 NNEKVVVKIL-KPVKK----KKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEH 115 KV +K L +P + K+ RE+++L+++R N+I L D+ TP + Sbjct: 49 TGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRH-ENVIGLLDVF------TPDETLDD 101 Query: 116 VNN---------TDFKQL--YQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMI 164 + TD +L ++ L + I+F +Y++LK L Y H+ GI+HRD+KP N+ + Sbjct: 102 FTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAV 161 Query: 165 DHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLAS 224 + E +L+++D+GLA E V +R+++ PE+++++ Y ++D+WS+GC++A Sbjct: 162 N-EDCELKILDFGLAR--QADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAE 218 Query: 225 MIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERF 284 MI K F G D+ DQL I KV GT +++ + + + L +K + Sbjct: 219 MITGK-TLFKGSDHLDQLKEIMKVTGTPPA-EFVQRLQSDEAKNYMKGLPELEKKDFASI 276 Query: 285 VHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTV 327 + + SP A++ L+K+L D + R+TA EA+ HPYF ++ Sbjct: 277 LTN-----ASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESL 314 >5AIR-A nrPDB Length = 430 Score = 139 bits (349), Expect = 3e-33, Method: Compositional matrix adjust. Identities = 115/370 (31%), Positives = 178/370 (48%), Gaps = 48/370 (12%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIK-REIKILENLRGGPNIITL 97 Y + +G G + V++A + E V +K K ++ K+ K RE++I+ L NI+ L Sbjct: 66 YTDTKVIGNGSFGVVYQAKLCDSGELVAIK--KVLQDKRFKNRELQIMRKLDHC-NIVRL 122 Query: 98 ------ADIVKDPVSRTPALVFEHVNNTDFK------QLYQTLTDYDIRFYMYEILKALD 145 + KD V LV ++V T ++ + QTL ++ YMY++ ++L Sbjct: 123 RYFFYSSGEKKDEVYLN--LVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLA 180 Query: 146 YCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVD 205 Y HS GI HRD+KP N+++D + L+L D+G A+ G+ + SRY++ PEL+ Sbjct: 181 YIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFG 240 Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNI-E 264 Y S+D+WS GC+LA ++ +P F G DQLV I KVLGT + I E Sbjct: 241 ATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTP------TREQIRE 293 Query: 265 LDPRFNDI-LGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323 ++P + + + W + PEA+ +LL Y +RLT EA H + Sbjct: 294 MNPNYTEFKFPQIKAHPWTKVFRPRT----PPEAIALCSRLLEYTPTARLTPLEACAHSF 349 Query: 324 FYTVVKDQARMGSSSMPGG-STPVSSANMMSGISSVPTPSPLGPLAGSP---VIAAANPL 379 F D+ R + +P G TP +SS P PL + P + AAA+P Sbjct: 350 F-----DELRDPNVKLPNGRDTPALFNFTTQELSSNP---PLATILIPPHARIQAAASP- 400 Query: 380 GMPVPAAAGA 389 PA A A Sbjct: 401 ----PANATA 406 >6GU6-A nrPDB Length = 302 Score = 139 bits (349), Expect = 3e-33, Method: Compositional matrix adjust. Identities = 93/304 (30%), Positives = 163/304 (53%), Gaps = 28/304 (9%) Query: 34 GNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK-----IKREIKILENL 88 G+ +DY + K+G G Y V++ + T + V +K ++ +++ REI +L+ L Sbjct: 4 GSMEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKEL 63 Query: 89 RGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY------QTLTDYDIRFYMYEILK 142 R PNI++L D++ SR L+FE ++ D K+ Q + ++ Y+Y+IL+ Sbjct: 64 RH-PNIVSLQDVLMQD-SRL-YLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQILQ 119 Query: 143 ALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE-FYHPGQEYNVRVASRYFKGPE 201 + +CHS ++HRD+KP N++ID + ++L D+GLA F P + Y V + +++ PE Sbjct: 120 GIVFCHSRRVLHRDLKPQNLLID-DKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPE 178 Query: 202 LLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKY 261 +L+ Y +D+WS+G + A + +K P FHG DQL RI + LGT Sbjct: 179 VLLGSARYSTPVDIWSIGTIFAELATKK-PLFHGDSEIDQLFRIFRALGTP--------- 228 Query: 262 NIELDPRFNDILG-RHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAME 320 N E+ P + +++ +W+ + + + LD L K+L YD R++ + A+ Sbjct: 229 NNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALN 288 Query: 321 HPYF 324 HPYF Sbjct: 289 HPYF 292 >4EWQ-A nrPDB Length = 383 Score = 137 bits (346), Expect = 6e-33, Method: Compositional matrix adjust. Identities = 96/328 (29%), Positives = 172/328 (52%), Gaps = 34/328 (10%) Query: 13 TDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL-K 71 ++ + RP ++ E + W + YQ + +G G Y V A + +V VK L + Sbjct: 22 SNASQERPT-FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSR 80 Query: 72 P----VKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNN--------- 118 P + K+ RE+++L++++ N+I L D+ TPA E N+ Sbjct: 81 PFQSIIHAKRTYRELRLLKHMKH-ENVIGLLDVF------TPARSLEEFNDVYLVTHLMG 133 Query: 119 TDFKQLY--QTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDW 176 D + Q LTD ++F +Y+IL+ L Y HS I+HRD+KP N+ ++ E +L+++D+ Sbjct: 134 ADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCELKILDF 192 Query: 177 GLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGH 236 GLA H E VA+R+++ PE+++++ Y+ ++D+WS+GC++A ++ + F G Sbjct: 193 GLAR--HTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGR-TLFPGT 249 Query: 237 DNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPE 296 D+ DQL I +++GT + + K + E + L + + + N P Sbjct: 250 DHIDQLKLILRLVGTPGA-ELLKKISSESARNYIQSLTQMPKMNFANVFIGAN-----PL 303 Query: 297 ALDFLDKLLRYDHQSRLTAREAMEHPYF 324 A+D L+K+L D R+TA +A+ H YF Sbjct: 304 AVDLLEKMLVLDSDKRITAAQALAHAYF 331 >4KRC-A nrPDB Length = 317 Score = 136 bits (342), Expect = 2e-32, Method: Compositional matrix adjust. Identities = 91/316 (28%), Positives = 170/316 (53%), Gaps = 27/316 (8%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIK----REIKILENLRGGPNI 94 ++ + KLG G Y+ V++ +N T V +K +K ++ REI +++ L+ NI Sbjct: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKH-ENI 65 Query: 95 ITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYD---------IRFYMYEILKALD 145 + L D++ T LVFE ++N D K+ + T + ++++ +++L+ L Sbjct: 66 VRLYDVIHTENKLT--LVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLA 122 Query: 146 YCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE-FYHPGQEYNVRVASRYFKGPELLV 204 +CH I+HRD+KP N++I+ + +L+L D+GLA F P ++ V + +++ P++L+ Sbjct: 123 FCHENKILHRDLKPQNLLIN-KRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLM 181 Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGT--EDLYDYIDKYN 262 + Y S+D+WS GC+LA MI K P F G ++ +QL I ++GT E L+ + K Sbjct: 182 GSRTYSTSIDIWSCGCILAEMITGK-PLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKL- 239 Query: 263 IELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHP 322 P++N + + + + + + + +DFL LL+ + RL+A++A+ HP Sbjct: 240 ----PKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHP 295 Query: 323 YFYTVVKDQARMGSSS 338 +F + GS S Sbjct: 296 WFAEYYHHASMGGSRS 311 >1UA2-A nrPDB Length = 346 Score = 135 bits (340), Expect = 3e-32, Method: Compositional matrix adjust. Identities = 97/304 (31%), Positives = 162/304 (53%), Gaps = 38/304 (12%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIK--------REIKILENLRG 90 Y+ + LG G+++ V++A + N+ V +K +K + + K REIK+L+ L Sbjct: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL-S 70 Query: 91 GPNIITLADIV--KDPVSRTPALVFEHVNNTDFKQLYQ----TLTDYDIRFYMYEILKAL 144 PNII L D K +S LVF+ + TD + + + LT I+ YM L+ L Sbjct: 71 HPNIIGLLDAFGHKSNIS----LVFDFME-TDLEVIIKDNSLVLTPSHIKAYMLMTLQGL 125 Query: 145 DYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE-FYHPGQEYNVRVASRYFKGPELL 203 +Y H I+HRD+KP+N+++D E+ L+L D+GLA+ F P + Y +V +R+++ PELL Sbjct: 126 EYLHQHWILHRDLKPNNLLLD-ENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELL 184 Query: 204 VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNI 263 +MY +DMW++GC+LA ++ R PF G + DQL RI + LGT Sbjct: 185 FGARMYGVGVDMWAVGCILAELLLRV-PFLPGDSDLDQLTRIFETLGTPT---------- 233 Query: 264 ELDPRFNDILGRHSRKRWERFVHSENQHLVSP---EALDFLDKLLRYDHQSRLTAREAME 320 + ++ D+ ++ F H+ S + LD + L ++ +R+TA +A++ Sbjct: 234 --EEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALK 291 Query: 321 HPYF 324 YF Sbjct: 292 MKYF 295 >5NGU-A nrPDB Length = 381 Score = 133 bits (334), Expect = 2e-31, Method: Compositional matrix adjust. Identities = 93/297 (31%), Positives = 158/297 (53%), Gaps = 31/297 (10%) Query: 45 LGRGKYSEVFEAINITNNEKVVVKILKPVKKK----KIKREIKILENLRGGPNIITLADI 100 +G G Y V A + N +V +K + P + + + REIKIL R NII + DI Sbjct: 50 IGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRH-ENIIGINDI 108 Query: 101 VKDPV--SRTPALVFEHVNNTDFKQLYQT--LTDYDIRFYMYEILKALDYCHSMGIMHRD 156 ++ P + + + TD +L +T L++ I +++Y+IL+ L Y HS ++HRD Sbjct: 109 IRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRD 168 Query: 157 VKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEY----NVRVASRYFKGPELLVDYQMYDYS 212 +KP N++++ L++ D+GLA P ++ VA+R+++ PE++++ + Y S Sbjct: 169 LKPSNLLLNTTC-DLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKS 227 Query: 213 LDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGT---EDLYDYIDKYNIELDPRF 269 +D+WS+GC+LA M+ + P F G DQL I +LG+ EDL I+ L R Sbjct: 228 IDIWSVGCILAEMLSNR-PIFPGKHYLDQLNHILGILGSPSQEDLNCIIN-----LKAR- 280 Query: 270 NDILGRHSRKR--WERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 N +L + + W R + + +ALD LDK+L ++ R+ +A+ HPY Sbjct: 281 NYLLSLPHKNKVPWNRLFPNADS-----KALDLLDKMLTFNPHKRIEVEQALAHPYL 332 >4QNY-A nrPDB Length = 354 Score = 132 bits (332), Expect = 2e-31, Method: Compositional matrix adjust. Identities = 94/309 (30%), Positives = 159/309 (51%), Gaps = 38/309 (12%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK---------KKIKREIKILEN 87 D Y L R +G G Y V A + ++ ++V +K V K K+I REIK+L + Sbjct: 20 DRYLLERIIGAGSYGVVIRARDTKSDNRLVA--MKRVNKEIFEEVILAKRILREIKLLAH 77 Query: 88 LRGGPNIITLADIV--KDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILK 142 NII L +I+ +DP + + + TD KQ+ Q LT+ I+F++Y+ L+ Sbjct: 78 F-NDDNIIGLRNILTPEDPENFDHFYIVMDIMETDLKQVLRSGQELTEAHIQFFIYQALR 136 Query: 143 ALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVR-VASRYFKGPE 201 AL HS G++HRD+ P N++++ + L++ D+GLA+ + EY V R+++ PE Sbjct: 137 ALHIIHSAGVIHRDITPANILVN-TNCDLKICDFGLAKEENDQGEYMTDYVTMRWYRAPE 195 Query: 202 LLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKY 261 L+++ + Y +D+W +GC+L ++ + P F G D +QL +I V+GT D Sbjct: 196 LVMEDKDYSAQIDVWGIGCILGELLGSR-PLFQGKDRVNQLDKIVDVIGTPSEED----- 249 Query: 262 NIELDPRFNDILGRHSRKRWERFVHSENQH------LVSPEALDFLDKLLRYDHQSRLTA 315 N + ++K ++ H SPEALD L +L ++ + R+T Sbjct: 250 -------INSVGSSAAQKYLKKKSHRPQADWRQRYPTASPEALDLLRHMLVFNPKRRITV 302 Query: 316 REAMEHPYF 324 +AM HP+ Sbjct: 303 LQAMRHPFL 311 >2F9G-A nrPDB Length = 353 Score = 131 bits (330), Expect = 4e-31, Method: Compositional matrix adjust. Identities = 96/311 (30%), Positives = 163/311 (52%), Gaps = 33/311 (10%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK----KIKREIKILENLRGGPN 93 D+QL LG G Y V A + E V +K ++P K + REIKIL++ + N Sbjct: 12 DFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHE-N 70 Query: 94 IITLADIVK-DPVSR-TPALVFEHVNNTDFKQLYQT--LTDYDIRFYMYEILKALDYCHS 149 IIT+ +I + D + + + TD ++ T L+D I++++Y+ L+A+ H Sbjct: 71 IITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHG 130 Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH---------PGQEYNVR--VASRYFK 198 ++HRD+KP N++I+ + L++ D+GLA GQ+ + VA+R+++ Sbjct: 131 SNVIHRDLKPSNLLIN-SNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYR 189 Query: 199 GPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYI 258 PE+++ Y ++D+WS GC+LA + R+ P F G D QL+ I ++GT + Sbjct: 190 APEVMLTSAKYSRAMDVWSCGCILAELFLRR-PIFPGRDYRHQLLLIFGIIGTP--HSDN 246 Query: 259 DKYNIELDPRFNDILGRHSRKRWERFVHSENQHL---VSPEALDFLDKLLRYDHQSRLTA 315 D IE PR R K + + + + V+P+ +D L ++L +D R+TA Sbjct: 247 DLRCIE-SPR-----AREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITA 300 Query: 316 REAMEHPYFYT 326 +EA+EHPY T Sbjct: 301 KEALEHPYLQT 311 >4AU8-A nrPDB Length = 296 Score = 131 bits (330), Expect = 4e-31, Method: Compositional matrix adjust. Identities = 95/303 (31%), Positives = 163/303 (53%), Gaps = 37/303 (12%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILK------PVKKKKIKREIKILENLRGGP 92 Y+ + K+G G Y VF+A N +E V +K ++ V + REI +L+ L+ Sbjct: 8 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSAL-REICLLKELKHK- 65 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLT-DYD---IRFYMYEILKALDYCH 148 NI+ L D++ T LVFE + D K+ + + D D ++ +++++LK L +CH Sbjct: 66 NIVRLHDVLHSDKKLT--LVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCH 122 Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE-FYHPGQEYNVRVASRYFKGPELLVDYQ 207 S ++HRD+KP N++I+ + +L+L D+GLA F P + Y+ V + +++ P++L + Sbjct: 123 SRNVLHRDLKPQNLLINR-NGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAK 181 Query: 208 MYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLG--TEDLYDYIDKYNIEL 265 +Y S+DMWS GC+ A + P F G+D DQL RI ++LG TE+ + + K Sbjct: 182 LYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKL---- 237 Query: 266 DPRFNDILGRHSRKRWERFVHSENQHLVSPE----ALDFLDKLLRYDHQSRLTAREAMEH 321 P + K + + + + V P+ D L LL+ + R++A EA++H Sbjct: 238 -PDY---------KPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQH 287 Query: 322 PYF 324 PYF Sbjct: 288 PYF 290 >4QTB-A nrPDB Length = 380 Score = 131 bits (330), Expect = 4e-31, Method: Compositional matrix adjust. Identities = 86/298 (28%), Positives = 155/298 (52%), Gaps = 21/298 (7%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK----KIKREIKILENLRGGPNI 94 Y ++ +G G Y V A + +V +K + P + + + REI+IL R N+ Sbjct: 43 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRH-ENV 101 Query: 95 ITLADIVKDPV--SRTPALVFEHVNNTDFKQLY--QTLTDYDIRFYMYEILKALDYCHSM 150 I + DI++ + + + + TD +L Q L++ I +++Y+IL+ L Y HS Sbjct: 102 IGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSA 161 Query: 151 GIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEY----NVRVASRYFKGPELLVDY 206 ++HRD+KP N++I+ L++ D+GLA P ++ VA+R+++ PE++++ Sbjct: 162 NVLHRDLKPSNLLINTTC-DLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNS 220 Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 266 + Y S+D+WS+GC+LA M+ + P F G DQL I +LG+ D N++ Sbjct: 221 KGYTKSIDIWSVGCILAEMLSNR-PIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKAR 279 Query: 267 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 + L ++ W + + +ALD LD++L ++ R+T EA+ HPY Sbjct: 280 -NYLQSLPSKTKVAWAKLFPKSDS-----KALDLLDRMLTFNPNKRITVEEALAHPYL 331 >3EB0-A nrPDB Length = 383 Score = 131 bits (329), Expect = 5e-31, Method: Compositional matrix adjust. Identities = 63/193 (32%), Positives = 110/193 (56%), Gaps = 11/193 (5%) Query: 133 IRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRV 192 I Y+Y++ +A+ + HS+GI HRD+KP N++++ + L+L D+G A+ P + + Sbjct: 143 ISIYIYQLFRAVGFIHSLGICHRDIKPQNLLVNSKDNTLKLCDFGSAKKLIPSEPSVAYI 202 Query: 193 ASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTE 252 SR+++ PEL++ Y S+D+WS+GC+ +I K P F G + DQLVRI +++GT Sbjct: 203 CSRFYRAPELMLGATEYTPSIDLWSIGCVFGELILGK-PLFSGETSIDQLVRIIQIMGTP 261 Query: 253 DLYDYIDKYNIELDPRFNDI-LGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQS 311 + I ++P + ++ K W + + L A+D L+++LRY+ Sbjct: 262 -----TKEQMIRMNPHYTEVRFPTLKAKDWRKILPEGTPSL----AIDLLEQILRYEPDL 312 Query: 312 RLTAREAMEHPYF 324 R+ EAM HP+F Sbjct: 313 RINPYEAMAHPFF 325 >3OZ6-A nrPDB Length = 388 Score = 130 bits (328), Expect = 7e-31, Method: Compositional matrix adjust. Identities = 95/329 (28%), Positives = 166/329 (50%), Gaps = 52/329 (15%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKIL-----KPVKKKKIKREIKILENLRGGPN 93 Y+LV+KLG+G Y V+++I+ E V VK + ++ REI IL L G N Sbjct: 11 YELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIFDAFQNSTDAQRTFREIMILTELSGHEN 70 Query: 94 IITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT--LTDYDIRFYMYEILKALDYCHSMG 151 I+ L ++++ R LVF+++ TD + + L ++ +Y+++K + Y HS G Sbjct: 71 IVNLLNVLRADNDRDVYLVFDYME-TDLHAVIRANILEPVHKQYVVYQLIKVIKYLHSGG 129 Query: 152 IMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVR-------------------- 191 ++HRD+KP N++++ E +++ D+GL+ + N+R Sbjct: 130 LLHRDMKPSNILLNAECH-VKVADFGLSRSF-----VNIRRVTNNIPLSINENTENFDDD 183 Query: 192 -------VASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVR 244 VA+R+++ PE+L+ Y +DMWSLGC+L ++ K P F G +QL R Sbjct: 184 QPILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGK-PIFPGSSTMNQLER 242 Query: 245 IAKVL---GTEDLYDYIDKYNIELDPRFND-ILGRHSRKR-----WERFVHSEN-QHLVS 294 I V+ ED+ + + + + R S KR W+ + N + + Sbjct: 243 IIGVIDFPSNEDVESIQSPFAKTMIESLKEKVEIRQSNKRDIFTKWKNLLLKINPKADCN 302 Query: 295 PEALDFLDKLLRYDHQSRLTAREAMEHPY 323 EALD LDKLL+++ R++A +A++HP+ Sbjct: 303 EEALDLLDKLLQFNPNKRISANDALKHPF 331 >6DTL-A nrPDB Length = 364 Score = 130 bits (326), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 84/302 (27%), Positives = 157/302 (51%), Gaps = 32/302 (10%) Query: 42 VRKLGRGKYSEVFEAINITNNEKVVVKIL-----KPVKKKKIKREIKILENLRGGPNIIT 96 + +G+G Y V A+N NE V +K + + K+ REIK+L ++ NI+ Sbjct: 35 IMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHM-DHENIVA 93 Query: 97 LADIVKDPVSRTPALVF--EHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCHSMG 151 + DI+ P+ V+ + +TD Q+ Q L++ ++++Y+IL+ L Y HS Sbjct: 94 IRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSAN 153 Query: 152 IMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDY 211 ++HRD+KP N++++ + L++ D+GLA V +R+++ PELL++ Y Sbjct: 154 VLHRDLKPSNLLLN-ANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTA 212 Query: 212 SLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYI------DKYNIEL 265 ++D+WS+GC+ ++ RK P F G D+ QL + +++GT + +Y +L Sbjct: 213 AIDVWSVGCIFMELMDRK-PLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQL 271 Query: 266 DPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFY 325 P + R ++ V P A+D ++K+L +D + R+T +A+ HPY Sbjct: 272 PP-------------YPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLN 318 Query: 326 TV 327 ++ Sbjct: 319 SL 320 >1G3N-A nrPDB Length = 326 Score = 128 bits (321), Expect = 5e-30, Method: Compositional matrix adjust. Identities = 98/333 (29%), Positives = 161/333 (48%), Gaps = 52/333 (15%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK--------KIKREIKILENLRG 90 Y+ V ++G G Y +VF+A ++ N + V LK V+ + RE+ +L +L Sbjct: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVA--LKRVRVQTGEEGMPLSTIREVAVLRHLET 70 Query: 91 --GPNIITLADIVKDPVSRTP-----ALVFEHVNNTDFKQLYQTLTDY------------ 131 PN++ L D+ VSRT LVFEHV+ Q LT Y Sbjct: 71 FEHPNVVRLFDVCT--VSRTDRETKLTLVFEHVD--------QDLTTYLDKVPEPGVPTE 120 Query: 132 DIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVR 191 I+ M+++L+ LD+ HS ++HRD+KP N+++ +++L D+GLA Y Sbjct: 121 TIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSG-QIKLADFGLARIYSFQMALTSV 179 Query: 192 VASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGT 251 V + +++ PE+L+ Y +D+WS+GC+ A M FR++P F G + DQL +I V+G Sbjct: 180 VVTLWYRAPEVLLQSS-YATPVDLWSVGCIFAEM-FRRKPLFRGSSDVDQLGKILDVIGL 237 Query: 252 EDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQS 311 D+ + PR S + E+FV + D L K L ++ Sbjct: 238 PGEEDWPRDVAL---PR--QAFHSKSAQPIEKFVTD-----IDELGKDLLLKCLTFNPAK 287 Query: 312 RLTAREAMEHPYFYTVVKDQARMGSSSMPGGST 344 R++A A+ HPYF + + + + S P +T Sbjct: 288 RISAYSALSHPYFQDLERCKENLDSHLPPSQNT 320 >4AGU-A nrPDB Length = 311 Score = 126 bits (317), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 92/315 (29%), Positives = 156/315 (49%), Gaps = 36/315 (11%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL-----KPVKKKKIKREIKILENLRGG 91 + Y+ + K+G G Y VF+ N + V +K PV KK REI++L+ L+ Sbjct: 3 EKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKH- 61 Query: 92 PNIITLADIVKDPVSRTPALVFEHVNNTDFKQL--YQT-LTDYDIRFYMYEILKALDYCH 148 PN++ L ++ + R LVFE+ ++T +L YQ + ++ ++ ++ L+A+++CH Sbjct: 62 PNLVNLLEVFRR--KRRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFCH 119 Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH-PGQEYNVRVASRYFKGPELLVDYQ 207 +HRDVKP N++I +H ++L D+G A P Y+ VA+R+++ PELLV Sbjct: 120 KHNCIHRDVKPENILIT-KHSVIKLCDFGFARLLTGPSDYYDDEVATRWYRSPELLVGDT 178 Query: 208 MYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDP 267 Y +D+W++GC+ A ++ P + G + DQL I K LG +L P Sbjct: 179 QYGPPVDVWAIGCVFAELL-SGVPLWPGKSDVDQLYLIRKTLG-------------DLIP 224 Query: 268 RFNDILGRHSRKRWERFVHSENQHL-------VSPEALDFLDKLLRYDHQSRLTAREAME 320 R + + + E+ +S AL L L D RLT + + Sbjct: 225 RHQQVFSTNQYFSGVKIPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTERLTCEQLLH 284 Query: 321 HPYFYTV--VKDQAR 333 HPYF + ++D A+ Sbjct: 285 HPYFENIREIEDLAK 299 >3GC0-A nrPDB Length = 329 Score = 124 bits (312), Expect = 6e-29, Method: Compositional matrix adjust. Identities = 85/301 (28%), Positives = 153/301 (50%), Gaps = 25/301 (8%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK-----IKREIKILENLRGG 91 D Y+ + KLG G Y EV++AI+ NE V +K ++ +++ RE+ +L+ L+ Sbjct: 34 DRYRRITKLGEGTYGEVYKAIDTVTNETVAIKRIRLEHEEEGVPGTAIREVSLLKELQHR 93 Query: 92 PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRF---YMYEILKALDYCH 148 NII L ++ + L+FE+ N D K+ D +R ++Y+++ +++CH Sbjct: 94 -NIIELKSVIHH--NHRLHLIFEYAEN-DLKKYMDKNPDVSMRVIKSFLYQLINGVNFCH 149 Query: 149 SMGIMHRDVKPHNVMID----HEHRKLRLIDWGLAE-FYHPGQEYNVRVASRYFKGPELL 203 S +HRD+KP N+++ E L++ D+GLA F P +++ + + +++ PE+L Sbjct: 150 SRRCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQFTHEIITLWYRPPEIL 209 Query: 204 VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNI 263 + + Y S+D+WS+ C+ A M+ K P F G DQL +I +VLG D + + Sbjct: 210 LGSRHYSTSVDIWSIACIWAEMLM-KTPLFPGDSEIDQLFKIFEVLGLPDDTTW---PGV 265 Query: 264 ELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323 P + + K +R + + +L D R++A+ A+EHPY Sbjct: 266 TALPDWKQSFPKFRGKTLKRVLGALLDDEGLDLL----TAMLEMDPVKRISAKNALEHPY 321 Query: 324 F 324 F Sbjct: 322 F 322 >4IC8-A nrPDB Length = 442 Score = 124 bits (311), Expect = 7e-29, Method: Compositional matrix adjust. Identities = 86/307 (28%), Positives = 155/307 (50%), Gaps = 31/307 (10%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP-----VKKKKIKREIKILENLRGG 91 D+Y+++ +G G Y V A ++V +K + K+ RE+KIL++ + Sbjct: 55 DEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHD 114 Query: 92 PNIITLADIVKDPV---SRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALD 145 NII + DI++ V V + +D Q+ Q LT +R+++Y++L+ L Sbjct: 115 -NIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLK 173 Query: 146 YCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGL--------AEFYHPGQEYNVRVASRYF 197 Y HS ++HRD+KP N++++ E+ +L++ D+G+ AE + EY VA+R++ Sbjct: 174 YMHSAQVIHRDLKPSNLLVN-ENCELKIGDFGMARGLCTSPAEHQYFMTEY---VATRWY 229 Query: 198 KGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDY 257 + PEL++ Y ++D+WS+GC+ M+ R++ F G + QL I VLGT Sbjct: 230 RAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQ-LFPGKNYVHQLQLIMMVLGTPS-PAV 287 Query: 258 IDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTARE 317 I E + L WE ++ +AL L ++LR++ +R++A Sbjct: 288 IQAVGAERVRAYIQSLPPRQPVPWETVYPGADR-----QALSLLGRMLRFEPSARISAAA 342 Query: 318 AMEHPYF 324 A+ HP+ Sbjct: 343 ALRHPFL 349 >5G6V-A nrPDB Length = 324 Score = 123 bits (308), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 86/303 (28%), Positives = 164/303 (54%), Gaps = 28/303 (9%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK----KIKREIKILENLRGGP 92 + Y + KLG G Y+ V++ + + V +K ++ ++ RE+ +L++L+ Sbjct: 2 ETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHA- 60 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTD-------YDIRFYMYEILKALD 145 NI+TL DI+ S T LVFE+++ K L Q L D ++++ +++++L+ L Sbjct: 61 NIVTLHDIIHTEKSLT--LVFEYLD----KDLKQYLDDCGNIINMHNVKLFLFQLLRGLA 114 Query: 146 YCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH-PGQEYNVRVASRYFKGPELLV 204 YCH ++HRD+KP N++I+ E +L+L D+GLA P + Y+ V + +++ P++L+ Sbjct: 115 YCHRQKVLHRDLKPQNLLIN-ERGELKLADFGLARAKSIPTKTYDNEVVTLWYRPPDILL 173 Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIE 264 Y +DMW +GC+ M + P F G +QL I ++LGT + + E Sbjct: 174 GSTDYSTQIDMWGVGCIFYEMATGR-PLFPGSTVEEQLHFIFRILGTPTEETWPGILSNE 232 Query: 265 LDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 +N + + R E + + + + D L KLL+++ ++R++A +AM+HP+F Sbjct: 233 EFKTYN-----YPKYRAEALLSHAPR--LDSDGADLLTKLLQFEGRNRISAEDAMKHPFF 285 Query: 325 YTV 327 ++ Sbjct: 286 LSL 288 >5EFQ-A nrPDB Length = 347 Score = 122 bits (306), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 89/319 (27%), Positives = 161/319 (50%), Gaps = 34/319 (10%) Query: 31 VEWGNQ--DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK-----IKREIK 83 ++WG + D + ++ +G G Y +V++A + E V +K ++ +K+ REIK Sbjct: 3 IDWGKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIK 62 Query: 84 ILENLRGGPNIITLADIVKDPVSRTPA--------LVFEHVNNTDFKQLYQTLTDYD--- 132 IL L +II + +IV D LVFE++++ L L ++ Sbjct: 63 ILRQL-THQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENH 121 Query: 133 IRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE--YNV 190 I+ +M ++++ LDYCH +HRD+K N+++++ +++L D+GLA Y + Y Sbjct: 122 IKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRG-QIKLADFGLARLYSSEESRPYTN 180 Query: 191 RVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLG 250 +V + +++ PELL+ + Y ++D+WS GC+L + F K+P F + QL I+++ G Sbjct: 181 KVITLWYRPPELLLGEERYTPAIDVWSCGCILGEL-FTKKPIFQANQELAQLELISRICG 239 Query: 251 TEDLYDYIDKYNIELDPRFNDI--LGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYD 308 + + D + P FN + ++ RK E FV + ALD D +L D Sbjct: 240 SPCPAVWPDVIKL---PYFNTMKPKKQYRRKLREEFV------FIPAAALDLFDYMLALD 290 Query: 309 HQSRLTAREAMEHPYFYTV 327 R TA +A++ + V Sbjct: 291 PSKRCTAEQALQCEFLRDV 309 >4ZSG-A nrPDB Length = 347 Score = 121 bits (303), Expect = 5e-28, Method: Compositional matrix adjust. Identities = 86/307 (28%), Positives = 155/307 (50%), Gaps = 31/307 (10%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK-----PVKKKKIKREIKILENLRGG 91 D+Y+++ +G G Y V A ++V +K + K+ RE+KIL++ + Sbjct: 7 DEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHD 66 Query: 92 PNIITLADIVKDPV---SRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALD 145 NII + DI++ V V + +D Q+ Q LT +R+++Y++L+ L Sbjct: 67 -NIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLK 125 Query: 146 YCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGL--------AEFYHPGQEYNVRVASRYF 197 Y HS ++HRD+KP N++++ E+ +L++ D+G+ AE + EY VA+R++ Sbjct: 126 YMHSAQVIHRDLKPSNLLVN-ENCELKIGDFGMARGLCTSPAEHQYFMTEY---VATRWY 181 Query: 198 KGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDY 257 + PEL++ Y ++D+WS+GC+ M+ R++ F G + QL I VLGT Sbjct: 182 RAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQ-LFPGKNYVHQLQLIMMVLGTPS-PAV 239 Query: 258 IDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTARE 317 I E + L WE ++ +AL L ++LR++ +R++A Sbjct: 240 IQAVGAERVRAYIQSLPPRQPVPWETVYPGADR-----QALSLLGRMLRFEPSARISAAA 294 Query: 318 AMEHPYF 324 A+ HP+ Sbjct: 295 ALRHPFL 301 >3E3P-A nrPDB Length = 360 Score = 118 bits (295), Expect = 5e-27, Method: Compositional matrix adjust. Identities = 87/308 (28%), Positives = 157/308 (50%), Gaps = 32/308 (10%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIK-REIKILENLR--GGPN 93 D +Q+ R G+G + V + + + V I K ++ + + RE++I+++L PN Sbjct: 23 DRFQVERMAGQGTFGTV--QLGKEKSTGMSVAIKKVIQDPRFRNRELQIMQDLAVLHHPN 80 Query: 94 IITLADIV-----KDPVSRTPALVFEHVNNTDFKQLYQTLTDY----------DIRFYMY 138 I+ L +D +V E+V +T L++ +Y I+ +++ Sbjct: 81 IVQLQSYFYTLGERDRRDIYLNVVMEYVPDT----LHRCCRNYYRRQVAPPPILIKVFLF 136 Query: 139 EILKALDYCH--SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY 196 ++++++ H S+ + HRD+KPHNV+++ L+L D+G A+ P + + SRY Sbjct: 137 QLIRSIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKLSPSEPNVAYICSRY 196 Query: 197 FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYD 256 ++ PEL+ Q Y ++D+WS+GC+ A M+ EP F G ++ QL I +VLG + Sbjct: 197 YRAPELIFGNQHYTTAVDIWSVGCIFAEMML-GEPIFRGDNSAGQLHEIVRVLGCPS-RE 254 Query: 257 YIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAR 316 + K L+P D+ +S+ V S++ + EA D L LL+Y + R+ Sbjct: 255 VLRK----LNPSHTDVDLYNSKGIPWSNVFSDHSLKDAKEAYDLLSALLQYLPEERMKPY 310 Query: 317 EAMEHPYF 324 EA+ HPYF Sbjct: 311 EALCHPYF 318 >4NST-A nrPDB Length = 351 Score = 117 bits (293), Expect = 9e-27, Method: Compositional matrix adjust. Identities = 87/329 (26%), Positives = 167/329 (50%), Gaps = 32/329 (9%) Query: 32 EWGNQ--DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK-----IKREIKI 84 +WG + D + ++ +G G Y +V++A + E V +K ++ +K+ REIKI Sbjct: 6 DWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKI 65 Query: 85 LENLRGGPNIITLADIVKDPVSRTPA--------LVFEHVNNTDFKQLYQTLTDYD---I 133 L L +++ + +IV D LVFE++++ L L + I Sbjct: 66 LRQLIHR-SVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHI 124 Query: 134 RFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE--YNVR 191 + +M ++++ L+YCH +HRD+K N+++++ +++L D+GLA Y+ + Y + Sbjct: 125 KSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSG-QIKLADFGLARLYNSEESRPYTNK 183 Query: 192 VASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGT 251 V + +++ PELL+ + Y ++D+WS GC+L + F K+P F + QL I+++ G+ Sbjct: 184 VITLWYRPPELLLGEERYTPAIDVWSCGCILGEL-FTKKPIFQANLELAQLELISRLCGS 242 Query: 252 EDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQS 311 + D + P FN + +K++ R + E + S ALD LD +L D Sbjct: 243 PCPAVWPDVIKL---PYFNTM---KPKKQYRRRLREEFSFIPSA-ALDLLDHMLTLDPSK 295 Query: 312 RLTAREAMEHPYFYTVVKDQARMGSSSMP 340 R TA + ++ + V + ++M +P Sbjct: 296 RCTAEQTLQSDFLKDV--ELSKMAPPDLP 322 >3PG1-A nrPDB Length = 362 Score = 117 bits (293), Expect = 9e-27, Method: Compositional matrix adjust. Identities = 82/312 (26%), Positives = 149/312 (47%), Gaps = 29/312 (9%) Query: 36 QDDYQLVRKLGRGKYSEVFEAI-------------NITNNEKVVVKILKPVKKKKIKREI 82 Q Y + R + G Y V + N ++ + V + K++ REI Sbjct: 21 QSPYTVQRFISSGSYGAVCAGVDSEGIPVAIKRVFNTVSDGRTVNILSDSFLCKRVLREI 80 Query: 83 KILENLRGGPNIITLADIV---KDPVSRTPALVFEHVNNTDFKQLYQ----TLTDYDIRF 135 ++L + PNI+ L DI ++P LV E + TD Q+ ++ I++ Sbjct: 81 RLLNHFHH-PNILGLRDIFVHFEEPAMHKLYLVTE-LMRTDLAQVIHDQRIVISPQHIQY 138 Query: 136 YMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASR 195 +MY IL L H G++HRD+ P N+++ ++ + + D+ LA V R Sbjct: 139 FMYHILLGLHVLHEAGVVHRDLHPGNILLA-DNNDITICDFNLAREDTADANKTHYVTHR 197 Query: 196 YFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLY 255 +++ PEL++ ++ + +DMWS GC++A M F ++ F G Y+QL +I +V+GT + Sbjct: 198 WYRAPELVMQFKGFTKLVDMWSAGCVMAEM-FNRKALFRGSTFYNQLNKIVEVVGTPKIE 256 Query: 256 DYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTA 315 D + + + L + W V + + P ALD + K+L ++ Q R++ Sbjct: 257 DVVMFSSPSARDYLRNSLSNVPARAWTAVVPTAD-----PVALDLIAKMLEFNPQRRIST 311 Query: 316 REAMEHPYFYTV 327 +A+ HPYF ++ Sbjct: 312 EQALRHPYFESL 323 >4BBM-A nrPDB Length = 331 Score = 117 bits (292), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 75/228 (32%), Positives = 127/228 (55%), Gaps = 14/228 (6%) Query: 33 WGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVK-ILKPVKKKKIK----REIKILEN 87 + + + Y+ + +G G Y V + N V +K L+ K +K REIK+L+ Sbjct: 21 FQSMEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQ 80 Query: 88 LRGGPNIITLADIVKDPVSRTPALVFEHVNNT--DFKQLYQTLTDYDI-RFYMYEILKAL 144 LR N++ L ++ K + LVFE V++T D +L+ DY + + Y+++I+ + Sbjct: 81 LRH-ENLVNLLEVCKK--KKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGI 137 Query: 145 DYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE-FYHPGQEYNVRVASRYFKGPELL 203 +CHS I+HRD+KP N+++ + ++L D+G A PG+ Y+ VA+R+++ PELL Sbjct: 138 GFCHSHNIIHRDIKPENILVS-QSGVVKLCDFGFARTLAAPGEVYDDEVATRWYRAPELL 196 Query: 204 VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGT 251 V Y ++D+W++GC++ M F EP F G + DQL I LG Sbjct: 197 VGDVKYGKAVDVWAIGCLVTEM-FMGEPLFPGDSDIDQLYHIMMCLGN 243 >4BGQ-A nrPDB Length = 304 Score = 116 bits (290), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 90/306 (29%), Positives = 151/306 (49%), Gaps = 33/306 (10%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK-----KKKIKREIKILENLRGG 91 + ++++ +G G Y V + + +E V +K K + K+ RE+K+L L+ Sbjct: 12 NKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ- 70 Query: 92 PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYCH 148 NI+ L + + LVFE+V + L + + ++ Y+Y+++KA+ +CH Sbjct: 71 ENIVELKEAFRR--RGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCH 128 Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ--EYNVRVASRYFKGPELLVDY 206 I+HRD+KP N++I H + L+L D+G A G Y+ VA+R+++ PELL+ Sbjct: 129 KNDIVHRDIKPENLLISH-NDVLKLCDFGFARNLSEGNNANYDEEVATRWYRSPELLLGA 187 Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLG---TEDLYDYIDKYNI 263 Y S+DMWS+GC+L + +P F G DQL I KVLG +E + + Sbjct: 188 P-YGKSVDMWSVGCILGEL-SDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYS---- 241 Query: 264 ELDPRFNDI---LGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAME 320 +PRF+ + H + R++ N L LD + LL+ D R + + Sbjct: 242 --NPRFHGLRFPAVNHPQSLERRYLGILNSVL-----LDLMKNLLKLDPADRYLTEQCLN 294 Query: 321 HPYFYT 326 HP F T Sbjct: 295 HPTFQT 300 >2I6L-A nrPDB Length = 320 Score = 114 bits (284), Expect = 9e-26, Method: Compositional matrix adjust. Identities = 86/308 (27%), Positives = 147/308 (47%), Gaps = 33/308 (10%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVK---ILKPVKKKKIKREIKILENLRG----- 90 Y ++ LG G VF A++ +++V +K + P K REIKI+ L Sbjct: 13 YMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKHALREIKIIRRLDHDNIVK 72 Query: 91 -----GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT--LTDYDIRFYMYEILKA 143 GP+ L D V + + TD + + L + R +MY++L+ Sbjct: 73 VFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLLRG 132 Query: 144 LDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVA----SRYFKG 199 L Y HS ++HRD+KP N+ I+ E L++ D+GLA P + ++ +++++ Sbjct: 133 LKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWYRS 192 Query: 200 PELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAK---VLGTEDLYD 256 P LL+ Y ++DMW+ GC+ A M+ K F H+ +Q+ I + V+ ED + Sbjct: 193 PRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHE-LEQMQLILESIPVVHEEDRQE 251 Query: 257 YIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAR 316 + + + ND+ H K + + +S EA+DFL+++L + RLTA Sbjct: 252 LLSVIPVYIR---NDMTEPH--KPLTQLLPG-----ISREAVDFLEQILTFSPMDRLTAE 301 Query: 317 EAMEHPYF 324 EA+ HPY Sbjct: 302 EALSHPYM 309 >3MIA-A nrPDB Length = 351 Score = 114 bits (284), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 92/309 (29%), Positives = 159/309 (51%), Gaps = 31/309 (10%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVK-ILKPVKKKKIK----REIKILENLRGGPN 93 Y+ + K+G+G + EVF+A + +KV +K +L +K+ REIKIL+ L+ N Sbjct: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH-EN 77 Query: 94 IITLADIVK---DPVSRTPA---LVFEHVNNTDFKQLYQTLTDY---DIRFYMYEILKAL 144 ++ L +I + P +R LVF+ + L L + +I+ M +L L Sbjct: 78 VVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGL 137 Query: 145 DYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ-----EYNVRVASRYFKG 199 Y H I+HRD+K NV+I + L+L D+GLA + + Y RV + +++ Sbjct: 138 YYIHRNKILHRDMKAANVLITRDG-VLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRP 196 Query: 200 PELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLG--TEDLYDY 257 PELL+ + Y +D+W GC++A M + + P G+ QL I+++ G T +++ Sbjct: 197 PELLLGERDYGPPIDLWGAGCIMAEM-WTRSPIMQGNTEQHQLALISQLCGSITPEVWPN 255 Query: 258 IDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTARE 317 +D Y EL + + G+ RK +R ++ P ALD +DKLL D R+ + + Sbjct: 256 VDNY--ELYEKLELVKGQ-KRKVKDRL----KAYVRDPYALDLIDKLLVLDPAQRIDSDD 308 Query: 318 AMEHPYFYT 326 A+ H +F++ Sbjct: 309 ALNHDFFWS 317 >3NIE-A nrPDB Length = 429 Score = 110 bits (274), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 94/367 (25%), Positives = 165/367 (44%), Gaps = 77/367 (20%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP-----VKKKKIKREIKILENLRGG 91 D+Y++ +GRG Y V+ A + N+ V +K + + K+I REI IL L+ Sbjct: 28 DNYEIKHLIGRGSYGYVYLAYDKNANKNVAIKKVNRMFEDLIDCKRILREITILNRLKSD 87 Query: 92 PNIITLADIV--KDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDY 146 II L D++ +D + + + ++D K+L++T LT+ ++ +Y +L + Sbjct: 88 -YIIRLHDLIIPEDLLKFDELYIVLEIADSDLKKLFKTPIFLTEQHVKTILYNLLLGEKF 146 Query: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH-------------------PG-- 185 H GI+HRD+KP N +++ + +++ D+GLA + PG Sbjct: 147 IHESGIIHRDLKPANCLLNQDC-SVKICDFGLARTINSDKDIHIVNDLEEKEENEEPGPH 205 Query: 186 -----QEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMI----------FRKE 230 ++ V +R+++ PEL++ + Y S+D+WS GC+ A ++ + Sbjct: 206 NKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDIWSTGCIFAELLNMMKSHINNPTNRF 265 Query: 231 PFF-----------------HGHDNYDQLVRIAKVLGT---EDLYDYIDKYNIELDPRFN 270 P F H N DQL I V+GT EDL + I+ F Sbjct: 266 PLFPGSSCFPLSPDHNSKKVHEKSNRDQLNIIFNVIGTPPEEDLKCITKQEVIKYIKLFP 325 Query: 271 DILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKD 330 G K++ +S E +D L+ +LR++ Q R+T +A+ HPY V K+ Sbjct: 326 TRDGIDLSKKYSS---------ISKEGIDLLESMLRFNAQKRITIDKALSHPYLKDVRKE 376 Query: 331 QARMGSS 337 S+ Sbjct: 377 NLENFST 383 >3RP9-A nrPDB Length = 458 Score = 109 bits (273), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 99/365 (27%), Positives = 161/365 (44%), Gaps = 78/365 (21%) Query: 32 EWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVK-ILKP----VKKKKIKREIKILE 86 +W D Y++ +G G Y V EA + V +K IL+ + K+I REI IL Sbjct: 48 DWQIPDRYEIRHLIGTGSYGHVCEAYDKLEKRVVAIKKILRVFEDLIDCKRILREIAILN 107 Query: 87 NLRGGPNIITLADIV--KDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEIL 141 L +++ + DIV KD V + ++DFK+L++T LT+ I+ +Y +L Sbjct: 108 RLNHD-HVVKVLDIVIPKDVEKFDELYVVLEIADSDFKKLFRTPVYLTELHIKTLLYNLL 166 Query: 142 KALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE--------------------- 180 + Y HS GI+HRD+KP N +++ + +++ D+GLA Sbjct: 167 VGVKYVHSAGILHRDLKPANCLVNQDC-SVKVCDFGLARTVDYPENGNSQLPISPREDDM 225 Query: 181 ----FYHP---GQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMI------- 226 F H ++ V +R+++ PEL++ + Y ++D+WS+GC+ A ++ Sbjct: 226 NLVTFPHTKNLKRQLTGHVVTRWYRAPELILLQENYTEAIDVWSIGCIFAELLNMIKENV 285 Query: 227 ---------------FRKEP--------FFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNI 263 F P FH N DQL I +LGT D I+ Sbjct: 286 AYHADRGPLFPGSSCFPLSPDQKAGNDFKFHTRGNRDQLNVIFNILGTPSEED-IEALEK 344 Query: 264 ELDPRFNDIL-GRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHP 322 E R+ I R ERF S S +A+ L ++L ++ R+T E + HP Sbjct: 345 EDAKRYIRIFPKREGTDLAERFPAS------SADAIHLLKRMLVFNPNKRITINECLAHP 398 Query: 323 YFYTV 327 +F V Sbjct: 399 FFKEV 403 >5Y86-A nrPDB Length = 588 Score = 108 bits (269), Expect = 5e-24, Method: Compositional matrix adjust. Identities = 98/400 (24%), Positives = 185/400 (46%), Gaps = 71/400 (17%) Query: 18 HRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK-- 75 H PR++ Y Y++++ +G+G + +V + + V +K+++ K+ Sbjct: 199 HVPRDHLAYR-----------YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFH 247 Query: 76 KKIKREIKILENLR-----GGPNIITLAD--IVKDPVSRTPALVFEHVNNTDFKQLYQTL 128 ++ EI+ILE+L+ G N+I + + ++ V L+ + K +Q Sbjct: 248 RQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGF 307 Query: 129 TDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHR-KLRLIDWGLAEFYHPGQE 187 + +R + IL++LD H I+H D+KP N+++ H R ++ID+G + F + Q+ Sbjct: 308 SVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEY--QK 365 Query: 188 YNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAK 247 + SR+++ PE+++ + Y +D+WS GC+LA ++ +P F G D DQL + + Sbjct: 366 LYTYIQSRFYRAPEIILGSR-YSTPIDIWSFGCILAELL-TGQPLFPGEDEGDQLACMME 423 Query: 248 VLG---------TEDLYDYIDKYNI--------ELDPRFNDILGRHSR---------KRW 281 +LG ++ +I+ I + D R + GR R K W Sbjct: 424 LLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDW 483 Query: 282 ERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPG 341 + + +L ++FL + L +D +RLT +A+ HP+ S S+P Sbjct: 484 GTALKGCDDYLF----IEFLKRCLHWDPSARLTPAQALRHPWI-----------SKSVP- 527 Query: 342 GSTPVSSANMMSGISSVPTPSPLGPLAGS--PVIAAANPL 379 P+++ + +SG V S L PV+ AN L Sbjct: 528 --RPLTTIDKVSGKRVVNPASAFQGLGSKLPPVVGIANKL 565 >4O2Z-A nrPDB Length = 377 Score = 107 bits (266), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 88/307 (28%), Positives = 147/307 (47%), Gaps = 40/307 (13%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK-----KKIKREIKIL-----ENL 88 Y L++ LG G Y ++ EKV +K + V + K++ REI ++ ENL Sbjct: 47 YTLLKILGMGAYGIACSCLDGDTGEKVSIKKCRDVFRDVEDGKRVLREIDMMRFFHHENL 106 Query: 89 RGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALD 145 NI L + ++ S V + + D + Q L + +++++Y+IL+ L Sbjct: 107 LNVVNI--LPPLKREYHSFEDVYVVTPLMDVDMNVVLRSRQVLEESHMQYFVYQILRGLK 164 Query: 146 YCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH-PGQEYNVRVASRYFKGPELLV 204 Y HS + HRD+KP N ++ + +L++ID+GL+ P E V +R+++ PELL+ Sbjct: 165 YLHSANVAHRDLKPAN-LVTNISCELKIIDFGLSRSVDVPYSELTDYVITRWYRPPELLL 223 Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIE 264 + Y ++D+WS+GC+ A M RK P F G + DQL IA+ +G Sbjct: 224 ENTNYSTAVDIWSVGCIFAEMYNRK-PVFPGRNTMDQLRMIAQHIGK------------- 269 Query: 265 LDPRFNDILGRHSRKRWERFVH-SENQHLVSP------EALDFLDKLLRYDHQSRLTARE 317 P + + R + ++ S N + P E +DFL K+ D R TA + Sbjct: 270 --PPASIVEHREALEKLNELPDGSLNIPKLVPGLAGNTEGIDFLSKMWTLDPSKRPTAAD 327 Query: 318 AMEHPYF 324 + HPY Sbjct: 328 MLAHPYL 334 >2W96-B nrPDB Length = 306 Score = 105 bits (263), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 88/307 (28%), Positives = 148/307 (48%), Gaps = 39/307 (12%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILK-PVKKKKIK----REIKILENLRG--G 91 Y+ V ++G G Y V++A + + V +K ++ P ++ + RE+ +L L Sbjct: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGLPISTVREVALLRRLEAFEH 65 Query: 92 PNIITLADIVKDPVSRTP-----ALVFEHVNNTDFKQLYQT----LTDYDIRFYMYEILK 142 PN++ L D+ SRT LVFEHV+ L + L I+ M + L+ Sbjct: 66 PNVVRLMDVCA--TSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLR 123 Query: 143 ALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPEL 202 LD+ H+ I+HRD+KP N+++ ++L D+GLA Y + V + +++ PE+ Sbjct: 124 GLDFLHANCIVHRDLKPENILVT-SGGTVKLADFGLARIYSYQMALDPVVVTLWYRAPEV 182 Query: 203 LVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYN 262 L+ Y +DMWS+GC+ A M FR++P F G+ DQL +I ++G D+ Sbjct: 183 LLQ-STYATPVDMWSVGCIFAEM-FRRKPLFCGNSEADQLGKIFDLIGLPPEDDW----- 235 Query: 263 IELDPRFNDILGRHSRKRWERFVHSENQHLVSPE----ALDFLDKLLRYDHQSRLTAREA 318 PR + R R V S V PE L ++L ++ R++A A Sbjct: 236 ----PRDVSLPRGAFPPRGPRPVQS-----VVPEMEESGAQLLLEMLTFNPHKRISAFRA 286 Query: 319 MEHPYFY 325 ++H Y + Sbjct: 287 LQHSYLH 293 >3ZDU-A nrPDB Length = 325 Score = 104 bits (259), Expect = 7e-23, Method: Compositional matrix adjust. Identities = 80/300 (26%), Positives = 147/300 (49%), Gaps = 31/300 (10%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIK----REIKILENLRGGPNI 94 Y+ + K+G G Y V + + + V +KI ++ + REIK L+ N+ Sbjct: 5 YETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQFHH-ENL 63 Query: 95 ITLADIVKDPVSRTPALVFEHVNNTDFKQL---YQTLTDYDIRFYMYEILKALDYCHSMG 151 + L ++ + + LVFE +++T +L L +R Y+++IL+A+DY HS Sbjct: 64 VNLIEVFRQ--KKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSNN 121 Query: 152 IMHRDVKPHNVMIDHEHRKLRLIDWGLAE-FYHPGQEYNVRVASRYFKGPELLVDYQMYD 210 I+HRD+KP N+++ + +L D+G A PG Y+ VA+R+++ PEL++ Y Sbjct: 122 IIHRDIKPENILVS-QSGITKLCDFGFARTLAAPGDIYDDEVATRWYRAPELVLKDTSYG 180 Query: 211 YSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFN 270 +D+W+LGCM+ M P+ + D L +I VL +L ++ P F Sbjct: 181 KPVDIWALGCMIIEMA-TGNPYLPSSSDLDLLHKI--VLKVGNLSPHLQNI-FSKSPIFA 236 Query: 271 DIL------GRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 ++ +++RK++ + N L D + L+ D R+++ + + H YF Sbjct: 237 GVVLPQVQHPKNARKKYPKL----NGLLA-----DIVHACLQIDPADRISSSDLLHHEYF 287 >5ZTN-A nrPDB Length = 429 Score = 103 bits (257), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 81/318 (25%), Positives = 158/318 (49%), Gaps = 36/318 (11%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK--KKIKREIKILENLR-----GG 91 Y++++ +G+G + +V +A + ++ V +K+++ K+ ++ EI+ILE+LR Sbjct: 99 YEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNT 158 Query: 92 PNIITLAD--IVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHS 149 N+I + + ++ + T L+ ++ K +Q + +R + + IL+ LD H Sbjct: 159 MNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHK 218 Query: 150 MGIMHRDVKPHNVMIDHEHRK-LRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQM 208 I+H D+KP N+++ + R +++ID+G + + H Q + SR+++ PE+++ + Sbjct: 219 NRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEH--QRVYTYIQSRFYRAPEVILGAR- 275 Query: 209 YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLG--TEDLYDYIDKYNIELD 266 Y +DMWSLGC+LA ++ P G D DQL + ++LG ++ L D + + Sbjct: 276 YGMPIDMWSLGCILAELL-TGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVS 334 Query: 267 ----PRFNDIL-----------GRHSRKRWERFVHSEN-----QHLVSPEALDFLDKLLR 306 PR+ + GR R + S + P LDFL + L Sbjct: 335 SKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLE 394 Query: 307 YDHQSRLTAREAMEHPYF 324 +D R+T +A+ HP+ Sbjct: 395 WDPAVRMTPGQALRHPWL 412 >3MN3-A nrPDB Length = 271 Score = 103 bits (256), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 64/203 (31%), Positives = 109/203 (53%), Gaps = 12/203 (5%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL------KPVKKKKIKREIKILENLRGG 91 +YQ+V+ LG G + +V A + T +KV +KI+ K + +I+REI L LR Sbjct: 5 NYQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRH- 63 Query: 92 PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ--TLTDYDIRFYMYEILKALDYCHS 149 P+II L D++K +V E+ N F + Q +++ + R + +I+ A++YCH Sbjct: 64 PHIIKLYDVIKS--KDEIIMVIEYAGNELFDYIVQRDKMSEQEARRFFQQIISAVEYCHR 121 Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMY 209 I+HRD+KP N+++D EH +++ D+GL+ G S + PE++ Sbjct: 122 HKIVHRDLKPENLLLD-EHLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKLYA 180 Query: 210 DYSLDMWSLGCMLASMIFRKEPF 232 +D+WS G +L M+ R+ PF Sbjct: 181 GPEVDVWSCGVILYVMLCRRLPF 203 >3E7O-A nrPDB Length = 360 Score = 102 bits (253), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 79/301 (26%), Positives = 146/301 (48%), Gaps = 20/301 (6%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKIL-KPVKK----KKIKREIKILENLRGGPN 93 YQ ++ +G G V A + V VK L +P + K+ RE+ +L+ + N Sbjct: 24 YQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCV-NHKN 82 Query: 94 IITLADIVKDPVS----RTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHS 149 II+L ++ + + LV E ++ + ++ L + + +Y++L + + HS Sbjct: 83 IISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHS 142 Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMY 209 GI+HRD+KP N+++ + L+++D+GLA V +RY++ PE+++ Y Sbjct: 143 AGIIHRDLKPSNIVVKSDC-TLKILDFGLARTASTNFMMTPYVVTRYYRAPEVILGMG-Y 200 Query: 210 DYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTED------LYDYIDKYNI 263 ++D+WS+GC++ ++ + F G D+ DQ ++ + LGT L + Y + Sbjct: 201 KENVDIWSVGCIMGELV-KGSVIFQGTDHIDQWNKVIEQLGTPSAEFMAALQPTVRNY-V 258 Query: 264 ELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323 E P + I W SE + + +A D L K+L D R++ EA+ HPY Sbjct: 259 ENRPAYPGIAFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPY 318 Query: 324 F 324 Sbjct: 319 I 319 >2X4F-A nrPDB Length = 373 Score = 101 bits (251), Expect = 6e-22, Method: Compositional matrix adjust. Identities = 86/332 (25%), Positives = 154/332 (46%), Gaps = 49/332 (14%) Query: 4 PVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRK---LGRGKYSEVFEAINIT 60 PV S+ V+ P +D+ + G + + V K LG G++ +V + Sbjct: 53 PVKSKRTSALAVDIPAPPAPFDHRIVTAKQGAVNSFYTVSKTEILGGGRFGQVHKCEETA 112 Query: 61 NNEKVVVKILKP---VKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVN 117 K+ KI+K K+++K EI ++ L N+I L D + LV E+V+ Sbjct: 113 TGLKLAAKIIKTRGMKDKEEVKNEISVMNQLDHA-NLIQLYDAFES--KNDIVLVMEYVD 169 Query: 118 NTD-FKQLYQ---TLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVM-IDHEHRKLR 172 + F ++ LT+ D +M +I + + + H M I+H D+KP N++ ++ + ++++ Sbjct: 170 GGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQMYILHLDLKPENILCVNRDAKQIK 229 Query: 173 LIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPF 232 +ID+GLA Y P ++ V + F PE +V+Y + DMWS+G + ++ PF Sbjct: 230 IIDFGLARRYKPREKLKVNFGTPEFLAPE-VVNYDFVSFPTDMWSVGVIAYMLLSGLSPF 288 Query: 233 FHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHL 292 +D A+ L N+IL RW+ + E Sbjct: 289 LGDND--------AETL--------------------NNILA----CRWD--LEDEEFQD 314 Query: 293 VSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 +S EA +F+ KLL + R++A EA++HP+ Sbjct: 315 ISEEAKEFISKLLIKEKSWRISASEALKHPWL 346 >5JN2-A nrPDB Length = 525 Score = 100 bits (249), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 81/311 (26%), Positives = 147/311 (47%), Gaps = 60/311 (19%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL--KPVKKKKIK----REIKILENLRG 90 D Y+ R LG+G + EV + ++ VK++ + VK+K K RE+++L+ L Sbjct: 67 DRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQL-D 125 Query: 91 GPNIITLADIVKDP--------VSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILK 142 PNI+ L + +D V L E ++ F ++ D + ++L Sbjct: 126 HPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEV-------DAARIIRQVLS 178 Query: 143 ALDYCHSMGIMHRDVKPHNVMIDHEHR--KLRLIDWGLAEFYHPGQEYNVRVASRYFKGP 200 + Y H I+HRD+KP N++++ + + +R+ID+GL+ + ++ ++ + Y+ P Sbjct: 179 GITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAP 238 Query: 201 ELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDK 260 E+L + YD D+WS G +L ++ P F+G + YD L ++ K K Sbjct: 239 EVL--HGTYDEKCDVWSTGVILY-ILLSGCPPFNGANEYDILKKVEK-----------GK 284 Query: 261 YNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAME 320 Y EL +W++ VS A D + K+L Y R++AR+A++ Sbjct: 285 YTFEL-------------PQWKK---------VSESAKDLIRKMLTYVPSMRISARDALD 322 Query: 321 HPYFYTVVKDQ 331 H + T K+Q Sbjct: 323 HEWIQTYTKEQ 333 >3N9X-A nrPDB Length = 432 Score = 99.8 bits (247), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 89/369 (24%), Positives = 165/369 (44%), Gaps = 84/369 (22%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP-----VKKKKIKREIKILENLRGG 91 D+Y + +GRG Y V+ A + + V +K + + K+I REI IL L+ Sbjct: 26 DNYIIKHLIGRGSYGYVYLAYDKNTEKNVAIKKVNRMFEDLIDCKRILREITILNRLKSD 85 Query: 92 PNIITLADIV--KDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDY 146 II L D++ D + + + ++D K+L++T LT+ I+ +Y +L ++ Sbjct: 86 -YIIRLYDLIIPDDLLKFDELYIVLEIADSDLKKLFKTPIFLTEEHIKTILYNLLLGENF 144 Query: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNV---------------- 190 H GI+HRD+KP N +++ + +++ D+GLA + ++ N+ Sbjct: 145 IHESGIIHRDLKPANCLLNQDC-SVKVCDFGLARTINSEKDTNIVNDLEENEEPGPHNKN 203 Query: 191 -------RVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMI----------FRKEPFF 233 V +R+++ PEL++ + Y S+D+WS GC+ A ++ + P F Sbjct: 204 LKKQLTSHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAELLNMLQSHINDPTNRFPLF 263 Query: 234 -----------------HGHDNYDQLVRIAKVLGT--EDLYDYIDKYNIELDPRFNDILG 274 H N DQL I ++GT ED I+K + Sbjct: 264 PGSSCFPLSPDRNSKKVHEKSNRDQLNIIFNIIGTPTEDDLKNINKPEV----------- 312 Query: 275 RHSRKRWERFVHSENQHL------VSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVV 328 K + F H + +L +S + ++ L+ +L+++ R+T +A++HPY V Sbjct: 313 ---IKYIKLFPHRKPINLKQKYPSISDDGINLLESMLKFNPNKRITIDQALDHPYLKDVR 369 Query: 329 KDQARMGSS 337 K + S+ Sbjct: 370 KKKLENFST 378 >1JNK-A nrPDB Length = 423 Score = 99.0 bits (245), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 79/311 (25%), Positives = 147/311 (47%), Gaps = 40/311 (12%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKIL-KPVKK----KKIKREIKILENLRGGPN 93 YQ ++ +G G V A + + V +K L +P + K+ RE+ +L N Sbjct: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYREL-VLMKCVNHKN 122 Query: 94 IITLADIVKDPVSRTPALVFEHVNNT---------DFKQLYQTLTDYD-IRFYMYEILKA 143 II+L ++ TP E + + Q+ Q D++ + + +Y++L Sbjct: 123 IISLLNVF------TPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCG 176 Query: 144 LDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELL 203 + + HS GI+HRD+KP N+++ + L+++D+GLA V +RY++ PE++ Sbjct: 177 IKHLHSAGIIHRDLKPSNIVVKSDC-TLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVI 235 Query: 204 VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNI 263 + Y ++D+WS+GC++ M+ R + F G D DQ ++ + LGT ++ Sbjct: 236 LGMG-YKENVDIWSVGCIMGEMV-RHKILFPGRDYIDQWNKVIEQLGTP-----CPEFMK 288 Query: 264 ELDPRFNDILGRHSRKRWERF----------VHSENQHLVSPEALDFLDKLLRYDHQSRL 313 +L P + + + F SE+ L + +A D L K+L D R+ Sbjct: 289 KLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRI 348 Query: 314 TAREAMEHPYF 324 + +A++HPY Sbjct: 349 SVDDALQHPYI 359 >3MA6-A nrPDB Length = 298 Score = 98.6 bits (244), Expect = 4e-21, Method: Compositional matrix adjust. Identities = 81/311 (26%), Positives = 147/311 (47%), Gaps = 60/311 (19%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL--KPVKKKKIK----REIKILENLRG 90 D Y+ R LG+G + EV + ++ VK++ + VK+K K RE+++L+ L Sbjct: 32 DRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQL-D 90 Query: 91 GPNIITLADIVKDP--------VSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILK 142 PNI+ L + +D V L E ++ F ++ D + ++L Sbjct: 91 HPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEV-------DAARIIRQVLS 143 Query: 143 ALDYCHSMGIMHRDVKPHNVMIDHEHR--KLRLIDWGLAEFYHPGQEYNVRVASRYFKGP 200 + Y H I+HRD+KP N++++ + + +R+ID+GL+ + ++ ++ + Y+ P Sbjct: 144 GITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAP 203 Query: 201 ELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDK 260 E+L + YD D+WS G +L ++ P F+G + YD L ++ K K Sbjct: 204 EVL--HGTYDEKCDVWSTGVILY-ILLSGCPPFNGANEYDILKKVEK-----------GK 249 Query: 261 YNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAME 320 Y EL +W++ VS A D + K+L Y R++AR+A++ Sbjct: 250 YTFELP-------------QWKK---------VSESAKDLIRKMLTYVPSMRISARDALD 287 Query: 321 HPYFYTVVKDQ 331 H + T K+Q Sbjct: 288 HEWIQTYTKEQ 298 >4NIF-A nrPDB Length = 333 Score = 98.2 bits (243), Expect = 5e-21, Method: Compositional matrix adjust. Identities = 84/296 (28%), Positives = 134/296 (45%), Gaps = 46/296 (15%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIIT 96 D Y + +G G YSE ++ N + VK++ K+ EI+IL PNIIT Sbjct: 8 DGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDP-SEEIEILLRYGQHPNIIT 66 Query: 97 LADIVKDPVSRTPALVFEHVNNTDF--KQLYQTL-TDYDIRFYMYEILKALDYCHSMGIM 153 L D+ D + LV E + + K L Q ++ + F ++ I K ++Y HS G++ Sbjct: 67 LKDVYDD--GKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVV 124 Query: 154 HRDVKPHNVMIDHEH---RKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLVDYQ 207 HRD+KP N++ E LR+ D+G A+ E + + Y F PE+L Q Sbjct: 125 HRDLKPSNILYVDESGNPECLRICDFGFAKQLRA--ENGLLMTPCYTANFVAPEVL-KRQ 181 Query: 208 MYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDP 267 YD D+WSLG +L +M+ PF +G + + Sbjct: 182 GYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPE-------------------------- 215 Query: 268 RFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323 +IL R ++ + N + VS A D + K+L D RLTA++ ++HP+ Sbjct: 216 ---EILTRIGSGKFT--LSGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPW 266 >4CRL-A nrPDB Length = 406 Score = 98.2 bits (243), Expect = 6e-21, Method: Compositional matrix adjust. Identities = 83/316 (26%), Positives = 150/316 (47%), Gaps = 41/316 (12%) Query: 44 KLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIK----REIKILENLRGGPNIITLAD 99 K+GRG Y V++A + LK ++ I REI +L L+ PN+I+L Sbjct: 29 KVGRGTYGHVYKAKRKDGKDDKDYA-LKQIEGTGISMSACREIALLRELKH-PNVISLQK 86 Query: 100 IVKDPVSRTPALVFEHVNN-----TDFKQLYQT------LTDYDIRFYMYEILKALDYCH 148 + R L+F++ + F + + L ++ +Y+IL + Y H Sbjct: 87 VFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHYLH 146 Query: 149 SMGIMHRDVKPHNVMI---DHEHRKLRLIDWGLAEFYH----PGQEYNVRVASRYFKGPE 201 + ++HRD+KP N+++ E ++++ D G A ++ P + + V + +++ PE Sbjct: 147 ANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPE 206 Query: 202 LLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHD---------NYDQLVRIAKVLGTE 252 LL+ + Y ++D+W++GC+ A ++ EP FH ++DQL RI V+G Sbjct: 207 LLLGARHYTKAIDIWAIGCIFAELL-TSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFP 265 Query: 253 DLYDYIDKYNIELDPRFNDILGRHSRKRWER--FVHSENQHLVSPE--ALDFLDKLLRYD 308 D+ D I+ P + ++ R + + +H V P+ A L KLL D Sbjct: 266 ADKDWED---IKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMD 322 Query: 309 HQSRLTAREAMEHPYF 324 R+T+ +AM+ PYF Sbjct: 323 PIKRITSEQAMQDPYF 338 >3FI2-A nrPDB Length = 353 Score = 97.4 bits (241), Expect = 8e-21, Method: Compositional matrix adjust. Identities = 79/311 (25%), Positives = 147/311 (47%), Gaps = 40/311 (12%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKIL-KPVKK----KKIKREIKILENLRGGPN 93 YQ ++ +G G V A + + V +K L +P + K+ RE+ +L N Sbjct: 26 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYREL-VLMKCVNHKN 84 Query: 94 IITLADIVKDPVSRTPALVFEHVNNT---------DFKQLYQTLTDYD-IRFYMYEILKA 143 II+L ++ TP E + + Q+ Q D++ + + +Y++L Sbjct: 85 IISLLNVF------TPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCG 138 Query: 144 LDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELL 203 + + HS GI+HRD+KP N+++ + L+++D+GLA V +RY++ PE++ Sbjct: 139 IKHLHSAGIIHRDLKPSNIVVKSDC-TLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVI 197 Query: 204 VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNI 263 + Y ++D+WS+GC++ M+ R + F G D DQ ++ + LGT ++ Sbjct: 198 LGMG-YKENVDIWSVGCIMGEMV-RHKILFPGRDYIDQWNKVIEQLGTP-----CPEFMK 250 Query: 264 ELDPRFNDILGRHSRKRWERF----------VHSENQHLVSPEALDFLDKLLRYDHQSRL 313 +L P + + + F SE+ L + +A D L K+L D R+ Sbjct: 251 KLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRI 310 Query: 314 TAREAMEHPYF 324 + +A++HPY Sbjct: 311 SVDDALQHPYI 321 >2XS0-A nrPDB Length = 386 Score = 97.4 bits (241), Expect = 8e-21, Method: Compositional matrix adjust. Identities = 81/304 (26%), Positives = 149/304 (49%), Gaps = 26/304 (8%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKIL-KPVKK----KKIKREIKILENLRGGPN 93 YQ ++ +G G V A + V +K L +P + K+ RE+ +L N Sbjct: 28 YQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYREL-VLMKCVNHKN 86 Query: 94 IITLADIVKDPVSRTP---ALVFEHVNNTDFKQLYQTLTDYD-IRFYMYEILKALDYCHS 149 II L ++ S + + + + Q+ Q D++ + + +Y++L + + HS Sbjct: 87 IIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHS 146 Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMY 209 GI+HRD+KP N+++ + L+++D+GLA V +RY++ PE+++ Y Sbjct: 147 AGIIHRDLKPSNIVVKSDC-TLKILDFGLARTAGTSFMMVPFVVTRYYRAPEVILGMG-Y 204 Query: 210 DYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGT------EDLYDYIDKYNI 263 ++D+WS+GC++ MI + F G D+ DQ ++ + LGT + L + Y + Sbjct: 205 KENVDIWSVGCIMGEMI-KGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQPTVRTY-V 262 Query: 264 ELDPRFNDILGRHSRKRWERFVH---SENQHLVSPEALDFLDKLLRYDHQSRLTAREAME 320 E P++ G K + + SE+ L + +A D L K+L D R++ EA++ Sbjct: 263 ENRPKYA---GYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQ 319 Query: 321 HPYF 324 HPY Sbjct: 320 HPYI 323 >5AWM-A nrPDB Length = 394 Score = 97.1 bits (240), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 88/337 (26%), Positives = 164/337 (48%), Gaps = 42/337 (12%) Query: 17 THRPREYWDYESHVVEWGNQD-----DYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL- 70 +HR ++ + VE G+ + Y +R +G G V A + + V +K L Sbjct: 19 SHRTMTTAQHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLS 78 Query: 71 KPVKK----KKIKREIKILENLRGGPNIITLADIVKDPVS----RTPALVFEHVNNTDFK 122 +P + K+ RE K+++ L NII L + + + LV E + + + Sbjct: 79 RPFQNVTHAKRAYREFKLMK-LVNHKNIIGLLNAFTPQRNLEEFQDVYLVME-LMDANLC 136 Query: 123 QLYQTLTDYD-IRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF 181 Q+ Q D+D + + +Y++L + + HS GI+HRD+KP N+++ + L+++D+GLA Sbjct: 137 QVIQMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADC-TLKILDFGLART 195 Query: 182 YHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQ 241 V +RY++ PE+++ Y ++D+WS+GC++ MI R F G D+ DQ Sbjct: 196 AGTTFMMTPYVVTRYYRAPEVILGMG-YTENVDIWSVGCIMGEMI-RGGVLFPGTDHIDQ 253 Query: 242 LVRIAKVLGT------EDLYDYIDKYNIELDPRFNDILGRHSRKRWERFV--------HS 287 +I + LGT + L + Y +E PR+ + ++R ++ Sbjct: 254 WNKIIEQLGTPSPSFMQRLQPTVRNY-VENRPRY-------TGYSFDRLFPDGLFPNDNN 305 Query: 288 ENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 +N + +A + L K+L D + R++ EA++H Y Sbjct: 306 QNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEYI 342 >2J90-A nrPDB Length = 304 Score = 96.7 bits (239), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 81/313 (25%), Positives = 146/313 (46%), Gaps = 53/313 (16%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP---------VKKKKIKREIKILE 86 +D Y++ +LG G+++ V + ++ K +K V +++I+RE+ IL Sbjct: 25 EDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILR 84 Query: 87 NLRGGPNIITLADIVKDPVSRTPALVFEHVNNT---DFKQLYQTLTDYDIRFYMYEILKA 143 +R PNIITL DI ++ L+ E V+ DF ++LT+ + ++ +IL Sbjct: 85 EIRH-PNIITLHDIFENKTD--VVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDG 141 Query: 144 LDYCHSMGIMHRDVKPHNVMIDHEHR---KLRLIDWGLAEFYHPGQEYNVRVASRYFKGP 200 + Y HS I H D+KP N+M+ ++ +++LID+G+A G E+ + F P Sbjct: 142 VHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFVAP 201 Query: 201 ELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDK 260 E +V+Y+ DMWS+G + ++ PF G + L I+ V YD+ ++ Sbjct: 202 E-IVNYEPLGLEADMWSIGVITYILLSGASPFL-GETKQETLTNISAV-----NYDFDEE 254 Query: 261 YNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAME 320 Y F++ S A DF+ +LL D + R+T +++E Sbjct: 255 Y-------FSN---------------------TSELAKDFIRRLLVKDPKRRMTIAQSLE 286 Query: 321 HPYFYTVVKDQAR 333 H + + + R Sbjct: 287 HSWIKAIRRRNVR 299 >3LIJ-A nrPDB Length = 494 Score = 95.9 bits (237), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 83/340 (24%), Positives = 152/340 (44%), Gaps = 57/340 (16%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK-----KKKIKREIKILENLRGGPN 93 YQ V+KLG G Y EV + + + +KI++ K+ E+ +L+ L PN Sbjct: 39 YQRVKKLGSGAYGEVLLCRDKVTHVERAIKIIRKTSVSTSSNSKLLEEVAVLK-LLDHPN 97 Query: 94 IITLADIVKDPVSRTPALVFEHVNNTD-FKQLYQTL--TDYDIRFYMYEILKALDYCHSM 150 I+ L D +D R LV E + F ++ + + D + ++L + Y H Sbjct: 98 IMKLYDFFEDK--RNYYLVMECYKGGELFDEIIHRMKFNEVDAAVIIKQVLSGVTYLHKH 155 Query: 151 GIMHRDVKPHNVMIDHEHRK--LRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQM 208 I+HRD+KP N++++ + + ++++D+GL+ + ++ R+ + Y+ PE+L + Sbjct: 156 NIVHRDLKPENLLLESKEKDALIKIVDFGLSAVFENQKKMKERLGTAYYIAPEVL--RKK 213 Query: 209 YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPR 268 YD D+WS+G +L ++ P F G + + L ++ K KY + P Sbjct: 214 YDEKCDVWSIGVILF-ILLAGYPPFGGQTDQEILRKVEK-----------GKYTFD-SPE 260 Query: 269 FNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVV 328 + + VS A D + ++L++D Q R++A++A+EHP+ Sbjct: 261 WKN---------------------VSEGAKDLIKQMLQFDSQRRISAQQALEHPWI---- 295 Query: 329 KDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLGPLA 368 M S G P S AN + + L A Sbjct: 296 ---KEMCSKKESGIELP-SLANAIENMRKFQNSQKLAQAA 331 >3NCG-A nrPDB Length = 486 Score = 95.1 bits (235), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 81/344 (23%), Positives = 148/344 (43%), Gaps = 65/344 (18%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK-----IKREIKILENLRGGPN 93 Y +V LG+G + EV + + ++ VK++ K I RE+++L+ L PN Sbjct: 24 YNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKL-DHPN 82 Query: 94 IITLADIVKDPVS-------RTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDY 146 I+ L +I++D S T +F+ + + +++D + ++ + Y Sbjct: 83 IMKLFEILEDSSSFYIVGELYTGGELFDEIIKR------KRFSEHDAARIIKQVFSGITY 136 Query: 147 CHSMGIMHRDVKPHNVMIDHEHR--KLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLV 204 H I+HRD+KP N++++ + + +++ID+GL+ + + R+ + Y+ PE+L Sbjct: 137 MHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVL- 195 Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIE 264 YD D+WS G +L ++ P F+G + YD L R+ KY + Sbjct: 196 -RGTYDEKCDVWSAGVILY-ILLSGTPPFYGKNEYDILKRVE-----------TGKYAFD 242 Query: 265 LDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 L +W +S +A D + K+L + R+TA + +EHP+ Sbjct: 243 L-------------PQW---------RTISDDAKDLIRKMLTFHPSLRITATQCLEHPWI 280 Query: 325 YTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLGPLA 368 SS P S S + M+ I L A Sbjct: 281 QKY--------SSETPTISDLPSLESAMTNIRQFQAEKKLAQAA 316 >3DFA-A nrPDB Length = 286 Score = 95.1 bits (235), Expect = 5e-20, Method: Compositional matrix adjust. Identities = 74/295 (25%), Positives = 141/295 (47%), Gaps = 49/295 (16%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK-----IKREIKILENLRGGPN 93 Y +V LG+G + EV + + ++ VK++ K I RE+++L+ L PN Sbjct: 24 YNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKL-DHPN 82 Query: 94 IITLADIVKDPVSRTPALVFE-HVNNTDFKQLYQT--LTDYDIRFYMYEILKALDYCHSM 150 I+ L +I++D S + +V E + F ++ + +++D + ++ + Y H Sbjct: 83 IMKLFEILED--SSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMHKH 140 Query: 151 GIMHRDVKPHNVMIDHEHR--KLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQM 208 I+HRD+KP N++++ + + +++ID+GL+ + + R+ + Y+ PE+L Sbjct: 141 NIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVL--RGT 198 Query: 209 YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPR 268 YD D+WS G +L ++ P F+G + YD L R+ KY +L P+ Sbjct: 199 YDEKCDVWSAGVILY-ILLSGTPPFYGKNEYDILKRVE-----------TGKYAFDL-PQ 245 Query: 269 FNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323 + I S +A D + K+L + R+TA + +EHP+ Sbjct: 246 WRTI---------------------SDDAKDLIRKMLTFHPSLRITATQCLEHPW 279 >1KOB-A nrPDB Length = 387 Score = 94.7 bits (234), Expect = 6e-20, Method: Compositional matrix adjust. Identities = 76/299 (25%), Positives = 130/299 (43%), Gaps = 52/299 (17%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK---PVKKKKIKREIKILENLRGGPN 93 D Y ++ +LG G + V + V K + P+ K +K EI I+ L P Sbjct: 51 DYYDILEELGSGAFGVVHRCVEKATGRVFVAKFINTPYPLDKYTVKNEISIMNQLHH-PK 109 Query: 94 IITLADIVKDPVSRTPAL-------VFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDY 146 +I L D +D L +F+ + D+K +++ ++ YM + + L + Sbjct: 110 LINLHDAFEDKYEMVLILEFLSGGELFDRIAAEDYK-----MSEAEVINYMRQACEGLKH 164 Query: 147 CHSMGIMHRDVKPHNVMID-HEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVD 205 H I+H D+KP N+M + + +++ID+GLA +P + V A+ F PE +VD Sbjct: 165 MHEHSIVHLDIKPENIMCETKKASSVKIIDFGLATKLNPDEIVKVTTATAEFAAPE-IVD 223 Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIEL 265 + + DMW++G + ++ P F G D+ + L + Sbjct: 224 REPVGFYTDMWAIGVLGYVLLSGLSP-FAGEDDLETLQNV-------------------- 262 Query: 266 DPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 R WE + VSPEA DF+ LL+ + + RLT +A+EHP+ Sbjct: 263 -----------KRCDWE--FDEDAFSSVSPEAKDFIKNLLQKEPRKRLTVHDALEHPWL 308 >3DXN-A nrPDB Length = 287 Score = 94.4 bits (233), Expect = 7e-20, Method: Compositional matrix adjust. Identities = 79/302 (26%), Positives = 132/302 (43%), Gaps = 50/302 (16%) Query: 34 GNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK------PVKKKKIKREIKILEN 87 G D YQ V+KLG G Y EV + + +KI+K + E+ +L+ Sbjct: 18 GLSDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQ 77 Query: 88 LRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQ---LYQTLTDYDIRFYMYEILKAL 144 L PNI+ L + +D R LV E + L Q ++ D M ++L Sbjct: 78 L-DHPNIMKLYEFFED--KRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLSGT 134 Query: 145 DYCHSMGIMHRDVKPHNVMIDHEHRK--LRLIDWGLAEFYHPGQEYNVRVASRYFKGPEL 202 Y H I+HRD+KP N++++ + R ++++D+GL+ + G + R+ + Y+ PE+ Sbjct: 135 TYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAPEV 194 Query: 203 LVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYN 262 L + YD D+WS G +L ++ PF G + + L R+ +K Sbjct: 195 L--RKKYDEKCDVWSCGVILYILLCGYPPF-GGQTDQEILKRV-------------EKGK 238 Query: 263 IELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHP 322 DP W + VS EA + +L Y+ R++A EA+ HP Sbjct: 239 FSFDP-----------PDWTQ---------VSDEAKQLVKLMLTYEPSKRISAEEALNHP 278 Query: 323 YF 324 + Sbjct: 279 WI 280 >4MVF-A nrPDB Length = 506 Score = 93.6 bits (231), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 78/311 (25%), Positives = 143/311 (45%), Gaps = 47/311 (15%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKR---EIKILENLRGGP 92 +D Y + KLG+G Y V++ I+ N+ +K K + K I R EI+I++ L P Sbjct: 56 EDKYIIDEKLGQGTYGCVYKGIDKVTNQLYAIKEEKKDRLKNINRFFQEIEIMKKL-DHP 114 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNTD-FKQLYQ--TLTDYDIRFYMYEILKALDYCHS 149 NI+ L + ++ L+ E + + F + + + T+ + M +I A+ Y HS Sbjct: 115 NIVKLYETYEN--DNYIYLIMELCSGRELFDSIIENGSFTEKNAATIMKQIFSAIFYLHS 172 Query: 150 MGIMHRDVKPHNVMIDHEHRK--LRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQ 207 + I+HRD+KP N + E++ L++ID+GL++ G+ + + Y+ P++L Sbjct: 173 LNIVHRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFTTTKAGTPYYVAPQVLDG-- 230 Query: 208 MYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDP 267 YD D+WS G ++ +++ PF+ D Sbjct: 231 KYDKKCDIWSSGVIMYTLLCGYPPFYGDTD------------------------------ 260 Query: 268 RFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTV 327 N++L + K+ E + + +S +A + + KLL Y+ R T EA+ HP+ + Sbjct: 261 --NEVLKK--VKKGEFCFYENDWGSISSDAKNLITKLLTYNPNERCTIEEALNHPWITQM 316 Query: 328 VKDQARMGSSS 338 K + SS Sbjct: 317 TKSHEHVELSS 327 >4F9B-A nrPDB Length = 361 Score = 92.8 bits (229), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 82/337 (24%), Positives = 144/337 (42%), Gaps = 54/337 (16%) Query: 39 YQLVRKLGRGKYSEVFEA---INITNNEKVVVKILKPVKKK-KIKREIKILENLRGGPNI 94 +++ K+G G +S V+ A + + EK+ +K L P +I E++ L G N+ Sbjct: 23 FKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQCLTVAGGQDNV 82 Query: 95 ITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMH 154 + + + + + ++ + F + +L+ ++R YM + KAL H GI+H Sbjct: 83 MGVKYCFRK--NDHVVIAMPYLEHESFLDILNSLSFQEVREYMLNLFKALKRIHQFGIVH 140 Query: 155 RDVKPHNVMIDHEHRKLRLIDWGLAEFYHPG----------------------------- 185 RDVKP N + + +K L+D+GLA+ H Sbjct: 141 RDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNKCSICLSRR 200 Query: 186 QEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRI 245 Q+ R + F+ PE+L ++DMWS G + S++ + PF+ D+ L +I Sbjct: 201 QQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDDLTALAQI 260 Query: 246 AKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERF------------------VHS 287 + G+ + + + ++ + RK ER + Sbjct: 261 MTIRGSRETIQAAKTFGKSILCS-KEVPAQDLRKLCERLRGMDSSTPKLTSDIQGHATNL 319 Query: 288 ENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 E + V EA D LDKLL + SR+TA EA+ HP+F Sbjct: 320 EGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFF 356 >4YNZ-A nrPDB Length = 342 Score = 92.8 bits (229), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 67/217 (30%), Positives = 112/217 (51%), Gaps = 14/217 (6%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK-----KIKREIKILENLRGGPN 93 Y+L + LG+G+ V I+ +KV +KI+ K K++REI IL+ L P+ Sbjct: 12 YRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSESVLMKVEREIAILK-LIEHPH 70 Query: 94 IITLADIVKDPVSRTPALVFEHVNNTD-FKQLYQT--LTDYDIRFYMYEILKALDYCHSM 150 ++ L D+ ++ + LV EHV+ + F L + LT + R + +I+ ALD+CHS Sbjct: 71 VLKLHDVYEN--KKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSH 128 Query: 151 GIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYD 210 I HRD+KP N+++D E +R+ D+G+A S ++ PE++ + Sbjct: 129 SICHRDLKPENLLLD-ERNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDG 187 Query: 211 YSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAK 247 D+WS G +L +++ PF DN QL+ K Sbjct: 188 RKADVWSCGVILFALLVGALPF--DDDNLRQLLEKVK 222 >3HZT-A nrPDB Length = 467 Score = 92.8 bits (229), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 79/302 (26%), Positives = 132/302 (43%), Gaps = 50/302 (16%) Query: 34 GNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK------PVKKKKIKREIKILEN 87 G D YQ V+KLG G Y EV + + +KI+K + E+ +L+ Sbjct: 1 GLSDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQ 60 Query: 88 LRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQ---LYQTLTDYDIRFYMYEILKAL 144 L PNI+ L + +D R LV E + L Q ++ D M ++L Sbjct: 61 L-DHPNIMKLYEFFEDK--RNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLSGT 117 Query: 145 DYCHSMGIMHRDVKPHNVMIDHEHRK--LRLIDWGLAEFYHPGQEYNVRVASRYFKGPEL 202 Y H I+HRD+KP N++++ + R ++++D+GL+ + G + R+ + Y+ PE+ Sbjct: 118 TYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAPEV 177 Query: 203 LVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYN 262 L + YD D+WS G +L ++ PF G + + L R+ +K Sbjct: 178 L--RKKYDEKCDVWSCGVILYILLCGYPPF-GGQTDQEILKRV-------------EKGK 221 Query: 263 IELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHP 322 DP W + VS EA + +L Y+ R++A EA+ HP Sbjct: 222 FSFDP-----------PDWTQ---------VSDEAKQLVKLMLTYEPSKRISAEEALNHP 261 Query: 323 YF 324 + Sbjct: 262 WI 263 >6FDY-U nrPDB Length = 276 Score = 92.4 bits (228), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 66/214 (30%), Positives = 105/214 (49%), Gaps = 20/214 (9%) Query: 33 WG--NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKR--------EI 82 WG D + L +LG G Y+ V++A + +VV +K V KK + + EI Sbjct: 5 WGPPRLDGFILTERLGSGTYATVYKAYAKKDTREVVA--IKCVAKKSLNKASVENLLTEI 62 Query: 83 KILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYE 139 +IL+ +R P+I+ L D D S L+ E D + T L + R +M + Sbjct: 63 EILKGIRH-PHIVQLKDFQWD--SDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQ 119 Query: 140 ILKALDYCHSMGIMHRDVKPHNVMIDH-EHRKLRLIDWGLAEFYHPGQEYNVRVASRYFK 198 + AL + H I H D+KP N+++ E L+L D+G A+ P E +V S + Sbjct: 120 LASALQFLHERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYM 179 Query: 199 GPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPF 232 PE++ Q YD +D+WS+G +L +F + PF Sbjct: 180 APEMVCQRQ-YDARVDLWSMGVILYEALFGQPPF 212 >5ES1-A nrPDB Length = 328 Score = 91.7 bits (226), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 58/208 (27%), Positives = 113/208 (54%), Gaps = 13/208 (6%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKI-----LKPVKKKKIKREIKILENLRGGP 92 +Y+L+R +G+G +++V A +I +V +KI L P +K+ RE++I++ L P Sbjct: 16 NYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGL-NHP 74 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNT---DFKQLYQTLTDYDIRFYMYEILKALDYCHS 149 NI+ L ++++ +T LV E+ + D+ + + + + R +I+ A+ YCH Sbjct: 75 NIVKLFEVIE--TEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQ 132 Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMY 209 I+HRD+K N+++D E +++ D+G + + G + + S + PEL + Sbjct: 133 KNIVHRDLKAENLLLDAEA-NIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYD 191 Query: 210 DYSLDMWSLGCMLASMIFRKEPFFHGHD 237 +D+WSLG +L +++ P F GH+ Sbjct: 192 GPEVDIWSLGVILYTLVSGSLP-FDGHN 218 >4JG6-A nrPDB Length = 355 Score = 91.7 bits (226), Expect = 6e-19, Method: Compositional matrix adjust. Identities = 84/299 (28%), Positives = 134/299 (44%), Gaps = 50/299 (16%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIIT 96 D Y++ +G G YS I+ N + VKI+ K+ + EI+IL PNIIT Sbjct: 35 DGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTE-EIEILLRYGQHPNIIT 93 Query: 97 LADIVKDPVSRTPALVFEHVNNTDF--KQLYQTL-TDYDIRFYMYEILKALDYCHSMGIM 153 L D+ D + +V E + + K L Q ++ + ++ I K ++Y H+ G++ Sbjct: 94 LKDVYDD--GKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVV 151 Query: 154 HRDVKPHNVMIDHEH---RKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLVDYQ 207 HRD+KP N++ E +R+ D+G A+ E + + Y F PE+L + Q Sbjct: 152 HRDLKPSNILYVDESGNPESIRICDFGFAKQLRA--ENGLLMTPCYTANFVAPEVL-ERQ 208 Query: 208 MYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQ--LVRIAKVLGTEDLYDYIDKYNIEL 265 YD + D+WSLG +L +M+ PF +G D+ + L RI K+++ Sbjct: 209 GYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGS-----------GKFSL-- 255 Query: 266 DPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 S W VS A D + K+L D RLTA + HP+ Sbjct: 256 -----------SGGYWNS---------VSDTAKDLVSKMLHVDPHQRLTAALVLRHPWI 294 >2Y7J-A nrPDB Length = 365 Score = 91.3 bits (225), Expect = 7e-19, Method: Compositional matrix adjust. Identities = 74/299 (24%), Positives = 140/299 (46%), Gaps = 56/299 (18%) Query: 45 LGRGKYSEVFEAINITNNEKVVVKILKPVKKK-----------KIKREIKILENLRGGPN 93 +GRG S V ++ + VKI++ ++ +RE IL + G P+ Sbjct: 102 IGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHILRQVAGHPH 161 Query: 94 IITLADIVKDPVSRTPALVFEHVNNTD-FKQLYQ--TLTDYDIRFYMYEILKALDYCHSM 150 IITL D + S LVF+ + + F L + L++ + R M +L+A+ + H+ Sbjct: 162 IITLIDSYES--SSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLEAVSFLHAN 219 Query: 151 GIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLV-----D 205 I+HRD+KP N+++D ++ ++RL D+G + PG++ + + PE+L Sbjct: 220 NIVHRDLKPENILLD-DNMQIRLSDFGFSCHLEPGEKLRELCGTPGYLAPEILKCSMDET 278 Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIEL 265 + Y +D+W+ G +L +++ PF+H Q++ + ++ E Y + Sbjct: 279 HPGYGKEVDLWACGVILFTLLAGSPPFWHRR----QILMLRMIM--EGQYQFS------- 325 Query: 266 DPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 P ++D S D + +LL+ D ++RLTA +A++HP+F Sbjct: 326 SPEWDD---------------------RSSTVKDLISRLLQVDPEARLTAEQALQHPFF 363 >3KN6-A nrPDB Length = 325 Score = 90.9 bits (224), Expect = 8e-19, Method: Compositional matrix adjust. Identities = 58/201 (28%), Positives = 108/201 (53%), Gaps = 10/201 (4%) Query: 43 RKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVK 102 + LG G +S + ++ +N+ VKI+ + ++EI L+ G PNI+ L ++ Sbjct: 17 KPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALKLCEGHPNIVKLHEVFH 76 Query: 103 DPVSRTPALVFEHVNNTD-FKQLYQT--LTDYDIRFYMYEILKALDYCHSMGIMHRDVKP 159 D + LV E +N + F+++ + ++ + + M +++ A+ + H +G++HRD+KP Sbjct: 77 DQLH--TFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLKP 134 Query: 160 HNVMIDHEHRKL--RLIDWGLAEFYHP-GQEYNVRVASRYFKGPELLVDYQMYDYSLDMW 216 N++ E+ L ++ID+G A P Q + ++ PELL + YD S D+W Sbjct: 135 ENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELL-NQNGYDESCDLW 193 Query: 217 SLGCMLASMIFRKEPFFHGHD 237 SLG +L +M+ + P F HD Sbjct: 194 SLGVILYTMLSGQVP-FQSHD 213 >3TAC-A nrPDB Length = 361 Score = 90.9 bits (224), Expect = 9e-19, Method: Compositional matrix adjust. Identities = 82/310 (26%), Positives = 136/310 (43%), Gaps = 63/310 (20%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK--------KKKIKREIKILEN 87 +D Y+L +G+G +S V IN ++ VKI+ K + +KRE I Sbjct: 25 EDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHM 84 Query: 88 LRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRF---------YMY 138 L+ P+I+ L + +VFE ++ D ++ + D F YM Sbjct: 85 LKH-PHIVELLETYSS--DGMLYMVFEFMDGADL--CFEIVKRADAGFVYSEAVASHYMR 139 Query: 139 EILKALDYCHSMGIMHRDVKPHNVMIDHEHRK--LRLIDWGLA-EFYHPGQEYNVRVASR 195 +IL+AL YCH I+HRDVKPH V++ + ++L +G+A + G RV + Sbjct: 140 QILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTP 199 Query: 196 YFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGT-EDL 254 +F PE +V + Y +D+W G +L ++ PF+ GT E L Sbjct: 200 HFMAPE-VVKREPYGKPVDVWGCGVILFILLSGCLPFY----------------GTKERL 242 Query: 255 YDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT 314 ++ I K +++PR +W +S A D + ++L D R+T Sbjct: 243 FEGIIKGKYKMNPR-----------QWSH---------ISESAKDLVRRMLMLDPAERIT 282 Query: 315 AREAMEHPYF 324 EA+ HP+ Sbjct: 283 VYEALNHPWL 292 >2YAB-A nrPDB Length = 361 Score = 90.5 bits (223), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 85/320 (26%), Positives = 148/320 (46%), Gaps = 55/320 (17%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP---------VKKKKIKREIKILE 86 +D Y + +LG G+++ V + + + K +K V +++I+RE+ IL Sbjct: 11 EDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIEREVSILR 70 Query: 87 NLRGGPNIITLADIVKDPVSRTPA-LVFEHVNNT---DFKQLYQTLTDYDIRFYMYEILK 142 + PNIITL D+ ++ RT L+ E V+ DF ++L++ + ++ +IL Sbjct: 71 QVLH-PNIITLHDVYEN---RTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILD 126 Query: 143 ALDYCHSMGIMHRDVKPHNVMIDHEHR---KLRLIDWGLAEFYHPGQEYNVRVASRYFKG 199 ++Y H+ I H D+KP N+M+ ++ ++LID+GLA G E+ + F Sbjct: 127 GVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVA 186 Query: 200 PELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYID 259 PE +V+Y+ DMWS+G + ++ PF G + L I V YD+ + Sbjct: 187 PE-IVNYEPLGLEADMWSIGVITYILLSGASPFL-GDTKQETLANITAV-----SYDFDE 239 Query: 260 KYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAM 319 ++ S+ L A DF+ KLL + + RLT +EA+ Sbjct: 240 EF------------------------FSQTSEL----AKDFIRKLLVKETRKRLTIQEAL 271 Query: 320 EHPYFYTVVKDQARMGSSSM 339 HP+ V QA + S+ Sbjct: 272 RHPWITPVDTQQAMVRRESV 291 >2VN9-A nrPDB Length = 301 Score = 89.4 bits (220), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 80/301 (26%), Positives = 142/301 (47%), Gaps = 53/301 (17%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK-----KKKIKREIKILENLRGG 91 D+YQL +LG+G +S V + I ++ KI+ K +K++RE +I L+ Sbjct: 4 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKH- 62 Query: 92 PNIITLADIVKDPVSRTPALVFEHVNNTD-FKQLY--QTLTDYDIRFYMYEILKALDYCH 148 PNI+ L D + + LVF+ V + F+ + + ++ D + +IL+++++CH Sbjct: 63 PNIVRLHDSISEEGFHY--LVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCH 120 Query: 149 SMGIMHRDVKPHNVMIDHEHR--KLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLVD 205 GI+HRD+KP N+++ + + ++L D+GLA E Q + + + PE+L Sbjct: 121 LNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRK 180 Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFF--HGHDNYDQLVRIAKVLGTEDLYDYIDKYNI 263 Y +DMW+ G +L ++ PF+ H Y Q+ A YD+ Sbjct: 181 -DPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGA--------YDF------ 225 Query: 264 ELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323 W+ V+PEA D ++K+L + R+TA EA++HP+ Sbjct: 226 -------------PSPEWDT---------VTPEAKDLINKMLTINPAKRITASEALKHPW 263 Query: 324 F 324 Sbjct: 264 I 264 >1ZWS-A nrPDB Length = 288 Score = 89.4 bits (220), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 83/313 (26%), Positives = 145/313 (46%), Gaps = 55/313 (17%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP---------VKKKKIKREIKILE 86 +D Y + +LG G+++ V + + + K +K V +++I+RE+ IL Sbjct: 11 EDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILR 70 Query: 87 NLRGGPNIITLADIVKDPVSRTPA-LVFEHVNNT---DFKQLYQTLTDYDIRFYMYEILK 142 + N+ITL D+ ++ RT L+ E V+ DF ++L++ + ++ +IL Sbjct: 71 QVLH-HNVITLHDVYEN---RTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILD 126 Query: 143 ALDYCHSMGIMHRDVKPHNVMIDHEHR---KLRLIDWGLAEFYHPGQEYNVRVASRYFKG 199 ++Y H+ I H D+KP N+M+ ++ ++LID+GLA G E+ + F Sbjct: 127 GVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVA 186 Query: 200 PELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYID 259 PE+ V+Y+ DMWS+G + ++ PF G + L I V YD+ + Sbjct: 187 PEI-VNYEPLGLEADMWSIGVITYILLSGASPFL-GDTKQETLANITSVS-----YDFDE 239 Query: 260 KYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAM 319 ++ F H+ S A DF+ KLL + + RLT +EA+ Sbjct: 240 EF----------------------FSHT------SELAKDFIRKLLVKETRKRLTIQEAL 271 Query: 320 EHPYFYTVVKDQA 332 HP+ V QA Sbjct: 272 RHPWITPVDNQQA 284 >5YKS-A nrPDB Length = 377 Score = 89.0 bits (219), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 55/209 (26%), Positives = 107/209 (51%), Gaps = 12/209 (5%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIK-----REIKILENLRGGPN 93 Y L + LGRG ++ V A ++ EKV VK++ K + +E++ ++ L PN Sbjct: 37 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMK-LVQHPN 95 Query: 94 IITLADIVKDPVSRTPALVFEHVNNTD----FKQLYQTLTDYDIRFYMYEILKALDYCHS 149 I+ L +++ L+ E + D + + L + + Y +I+ A+ YCH Sbjct: 96 IVRLYEVID--TQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHK 153 Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMY 209 + ++HRD+KP NV+ + ++L D+G + + PG++ S + PE+L+ + Sbjct: 154 LHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYD 213 Query: 210 DYSLDMWSLGCMLASMIFRKEPFFHGHDN 238 ++D+WSLG +L ++ + PF +D+ Sbjct: 214 APAVDIWSLGVILFMLVCGQPPFQEANDS 242 >4C0T-A nrPDB Length = 974 Score = 88.6 bits (218), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 69/233 (29%), Positives = 114/233 (48%), Gaps = 24/233 (10%) Query: 35 NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP---VKKKKIKR---EIKILENL 88 N D++ ++LG G YS V A + ++ VK+L +K+KK+K E L L Sbjct: 264 NVTDFKFGKELGEGSYSTVILATDKITGKQYAVKVLDKRHIIKEKKVKYVNIEKHALNRL 323 Query: 89 RGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQL---YQTLTDYDIRFYMYEILKALD 145 +I+L +D S V ++ +N + L Y TL + R + +IL A+ Sbjct: 324 SNRLGVISLYFTFQDKDSL--YFVLDYASNGELLTLIKRYNTLNEECTRHFGAQILDAIK 381 Query: 146 YCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHP----GQEYNVRVASRYFKG-- 199 Y H G++HRD+KP N+++D + R +++ D+G A +EY V V ++ F G Sbjct: 382 YMHDNGVIHRDLKPENILLDDKMR-IQITDFGTARLLEKKNDESEEYPVDVRAKSFVGTA 440 Query: 200 ----PELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKV 248 PELL + + D+W+ GC++ MI K P F + Y +I K+ Sbjct: 441 EYVSPELL-ENKYCGKPGDVWAFGCIIYQMIAGKPP-FKATNEYLTFQKITKL 491 >6QAU-A nrPDB Length = 280 Score = 88.2 bits (217), Expect = 5e-18, Method: Compositional matrix adjust. Identities = 59/206 (28%), Positives = 105/206 (50%), Gaps = 24/206 (11%) Query: 45 LGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKR-------EIKILENLRGGPNIITL 97 +G G ++ VF + + V +K + KK + + EIKIL+ L+ NI+ L Sbjct: 19 VGHGAFAVVFRGRHRQKTDWEVA--IKSINKKNLSKSQILLGKEIKILKELQH-ENIVAL 75 Query: 98 ADIVKDPVSRTPALVFEHVNN---TDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMH 154 D+ + P + LV E+ N D+ Q TL++ IR ++++I A+ HS GI+H Sbjct: 76 YDVQELP--NSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRILHSKGIIH 133 Query: 155 RDVKPHNVMIDHEHR--------KLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDY 206 RD+KP N+++ + +R ++++ D+G A + H S + PE+++ Sbjct: 134 RDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAADLCGSPMYMAPEVIMS- 192 Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPF 232 Q YD D+WS+G ++ + K PF Sbjct: 193 QHYDAKADLWSIGTVIYQCLVGKPPF 218 >5XZW-A nrPDB Length = 471 Score = 88.2 bits (217), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 80/308 (25%), Positives = 137/308 (44%), Gaps = 58/308 (18%) Query: 38 DYQLVRKL-GRGKYSEVFEAINITNNEKVVVKILKPVK----KKKIKREIKILENLRGGP 92 D+ ++ ++ G+G ++ V +AI T + VKI+ K + RE+++L+ L P Sbjct: 196 DFSIIDEVVGQGAFATVKKAIERTTGKTFAVKIISKRKVIGNMDGVTRELEVLQKLNH-P 254 Query: 93 NIITLADIVKDPVSRTPALVFEHVNN---TDFKQLYQTLTDYDIRFYMYEILKALDYCHS 149 I+ L +D + + +V E V+ DF + + + R +IL A+ Y HS Sbjct: 255 RIVRLKGFYED--TESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHS 312 Query: 150 MGIMHRDVKPHNVMIDHEHRKL-RLIDWGLAEFYHPGQEYNVRVASRYFKGPELL----- 203 MGI HRD+KP N++I+ + L ++ D+GLA+ G + + PE++ Sbjct: 313 MGISHRDLKPDNILIEQDDPVLVKITDFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDT 372 Query: 204 -------VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYD 256 + Y +DMWS+GC++ ++ PF DQ LY Sbjct: 373 SVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPF--SGSTQDQ------------LYK 418 Query: 257 YIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAR 316 I + G + + F +S EA DF+D LL+ D +R TA Sbjct: 419 QIGR-------------GSYHEGPLKDF-------RISEEARDFIDSLLQVDPNNRSTAA 458 Query: 317 EAMEHPYF 324 +A+ HP+ Sbjct: 459 KALNHPWI 466 >2HW6-A nrPDB Length = 307 Score = 87.8 bits (216), Expect = 7e-18, Method: Compositional matrix adjust. Identities = 80/315 (25%), Positives = 140/315 (44%), Gaps = 54/315 (17%) Query: 36 QDDYQLVRKL-GRGKYSEVFEAINITNNEKVVVKILKPV---KKKKIKREIKILENLRGG 91 +D Y+L +L G G Y++V A+++ N ++ VKI++ + ++ RE++ L +G Sbjct: 11 EDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGN 70 Query: 92 PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIR---FYMYEILKALDYCH 148 NI+ L + +D LVFE + Q ++ R + ++ ALD+ H Sbjct: 71 KNILELIEFFEDDTRFY--LVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLH 128 Query: 149 SMGIMHRDVKPHNVMIDHEHR--KLRLIDWGLAEFYHPGQ--------EYNVRVASRYFK 198 + GI HRD+KP N++ + + +++ D+ L E S + Sbjct: 129 TKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYM 188 Query: 199 GPELLVDY----QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYD------QLVRIAKV 248 PE++ + YD D+WSLG +L M+ PF GH D ++ R+ + Sbjct: 189 APEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFV-GHCGADCGWDRGEVCRVCQ- 246 Query: 249 LGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYD 308 L++ I + E F D K W +S EA D + KLL D Sbjct: 247 ---NKLFESIQEGKYE----FPD-------KDWAH---------ISSEAKDLISKLLVRD 283 Query: 309 HQSRLTAREAMEHPY 323 + RL+A + ++HP+ Sbjct: 284 AKQRLSAAQVLQHPW 298 >3D2K-A nrPDB Length = 272 Score = 87.8 bits (216), Expect = 7e-18, Method: Compositional matrix adjust. Identities = 76/297 (25%), Positives = 138/297 (46%), Gaps = 55/297 (18%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK------IKREIKILENLRG 90 +D+ + R LG+GK+ V+ A + + +K+L + +K ++RE++I +LR Sbjct: 12 EDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVEHQLRREVEIQSHLRH 71 Query: 91 GPNIITLADIVKDPVSRTPALVFEHVN-NTDFKQLYQTLTDYD---IRFYMYEILKALDY 146 PNI+ L D L+ E+ T +++L Q L+ +D Y+ E+ AL Y Sbjct: 72 -PNILRLYGYFHDATR--VYLILEYAPLGTVYREL-QKLSRFDEQRTATYITELANALSY 127 Query: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDY 206 CHS ++HRD+KP N+++ + +L++ D+G + + P + + PE +++ Sbjct: 128 CHSKRVIHRDIKPENLLLG-SNGELKIADFGWS-VHAPSSRRTTLCGTLDYLPPE-MIEG 184 Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 266 +M+D +D+WSLG + + P F H + RI++V T Sbjct: 185 RMHDEKVDLWSLGVLCYEFLVGMPP-FEAHTYQETYRRISRVEFT--------------- 228 Query: 267 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323 F D V+ A D + +LL+++ RLT E +EHP+ Sbjct: 229 --FPD--------------------FVTEGARDLISRLLKHNASQRLTLAEVLEHPW 263 >2VZ6-A nrPDB Length = 313 Score = 87.4 bits (215), Expect = 8e-18, Method: Compositional matrix adjust. Identities = 78/302 (25%), Positives = 141/302 (46%), Gaps = 53/302 (17%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK-----KKKIKREIKILENLRG 90 Q YQL +LG+G +S V + + ++ KI+ K +K++RE +I L+ Sbjct: 21 QSMYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKH 80 Query: 91 GPNIITLADIVKDPVSRTPALVFEHVNNTD-FKQLY--QTLTDYDIRFYMYEILKALDYC 147 PNI+ L D + + L+F+ V + F+ + + ++ D + +IL+A+ +C Sbjct: 81 -PNIVRLHDSISEEGHHY--LIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHC 137 Query: 148 HSMGIMHRDVKPHNVMIDHEHR--KLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLV 204 H MG++HRD+KP N+++ + + ++L D+GLA E Q + + + PE+L Sbjct: 138 HQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLR 197 Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPFF--HGHDNYDQLVRIAKVLGTEDLYDYIDKYN 262 Y +D+W+ G +L ++ PF+ H Y Q+ A YD+ Sbjct: 198 K-DPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGA--------YDF----- 243 Query: 263 IELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHP 322 W+ V+PEA D ++K+L + R+TA EA++HP Sbjct: 244 --------------PSPEWDT---------VTPEAKDLINKMLTINPSKRITAAEALKHP 280 Query: 323 YF 324 + Sbjct: 281 WI 282 >3F3Z-A nrPDB Length = 277 Score = 87.4 bits (215), Expect = 9e-18, Method: Compositional matrix adjust. Identities = 78/294 (26%), Positives = 136/294 (46%), Gaps = 47/294 (15%) Query: 39 YQLVRKLGRGKYSEVFEAINI-TNNEKVVVKILKPVKKK--KIKREIKILENLRGGPNII 95 Y L +GRG + EV A+ T + KI K + + K+EI+I+++L PNII Sbjct: 11 YTLENTIGRGSWGEVKIAVQKGTRIRRAAKKIPKYFVEDVDRFKQEIEIMKSL-DHPNII 69 Query: 96 TLADIVKDPVSRTPALVFEHVNNTD-FKQLY--QTLTDYDIRFYMYEILKALDYCHSMGI 152 L + +D + LV E + F+++ + + D M ++L A+ YCH + + Sbjct: 70 RLYETFED--NTDIYLVMELCTGGELFERVVHKRVFRESDAARIMKDVLSAVAYCHKLNV 127 Query: 153 MHRDVKPHNVMI--DHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYD 210 HRD+KP N + D L+LID+GLA + PG+ +V + Y+ P++L +Y Sbjct: 128 AHRDLKPENFLFLTDSPDSPLKLIDFGLAARFKPGKMMRTKVGTPYYVSPQVLEG--LYG 185 Query: 211 YSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFN 270 D WS G M+ ++ PF D+ + +++I + T D+++ Sbjct: 186 PECDEWSAGVMMYVLLCGYPPFSAPTDS-EVMLKIREGTFTFPEKDWLN----------- 233 Query: 271 DILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 VSP+A + +LL + R+T+ +A+EH +F Sbjct: 234 ----------------------VSPQAESLIRRLLTKSPKQRITSLQALEHEWF 265 >1TKI-A nrPDB Length = 321 Score = 87.4 bits (215), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 71/297 (23%), Positives = 141/297 (47%), Gaps = 49/297 (16%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP--VKKKKIKREIKILENLRGGPNI 94 + Y + LGRG++ V + ++ + + K +K + +K+EI IL N+ NI Sbjct: 5 EKYMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVKGTDQVLVKKEISIL-NIARHRNI 63 Query: 95 ITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----LTDYDIRFYMYEILKALDYCHSM 150 + L + + ++FE ++ D + T L + +I Y++++ +AL + HS Sbjct: 64 LHLHESFESM--EELVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCEALQFLHSH 121 Query: 151 GIMHRDVKPHNVMIDHEHRK---LRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQ 207 I H D++P N++ ++ R+ +++I++G A PG + + + + PE+ + Sbjct: 122 NIGHFDIRPENII--YQTRRSSTIKIIEFGQARQLKPGDNFRLLFTAPEYYAPEVH-QHD 178 Query: 208 MYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDP 267 + + DMWSLG ++ ++ PF + Q+ I ++ E +D + Sbjct: 179 VVSTATDMWSLGTLVYVLLSGINPFL--AETNQQI--IENIMNAEYTFD---------EE 225 Query: 268 RFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 F +I S EA+DF+D+LL + +SR+TA EA++HP+ Sbjct: 226 AFKEI---------------------SIEAMDFVDRLLVKERKSRMTASEALQHPWL 261 >5U6Y-A nrPDB Length = 461 Score = 87.0 bits (214), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 77/299 (25%), Positives = 140/299 (46%), Gaps = 53/299 (17%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK-----KKKIKREIKILENLRGGPN 93 YQL +LG+G +S V + + ++ KI+ K +K++RE +I L+ PN Sbjct: 2 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKH-PN 60 Query: 94 IITLADIVKDPVSRTPALVFEHVNNTD-FKQLY--QTLTDYDIRFYMYEILKALDYCHSM 150 I+ L D + + L+F+ V + F+ + + ++ D + +IL+A+ +CH M Sbjct: 61 IVRLHDSISEEGHHY--LIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQM 118 Query: 151 GIMHRDVKPHNVMIDHEHR--KLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLVDYQ 207 G++HRD+KP N+++ + + ++L D+GLA E Q + + + PE+L Sbjct: 119 GVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRK-D 177 Query: 208 MYDYSLDMWSLGCMLASMIFRKEPFF--HGHDNYDQLVRIAKVLGTEDLYDYIDKYNIEL 265 Y +D+W+ G +L ++ PF+ H Y Q+ A YD+ Sbjct: 178 PYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGA--------YDF-------- 221 Query: 266 DPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 W+ V+PEA D ++K+L + R+TA EA++HP+ Sbjct: 222 -----------PSPEWD---------TVTPEAKDLINKMLTINPSKRITAAEALKHPWI 260 >2A27-A nrPDB Length = 321 Score = 87.0 bits (214), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 83/320 (25%), Positives = 147/320 (45%), Gaps = 55/320 (17%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP---------VKKKKIKREIKILE 86 +D Y + +LG G+++ V + + + K +K V +++I+RE+ IL Sbjct: 11 EDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILR 70 Query: 87 NLRGGPNIITLADIVKDPVSRTPA-LVFEHVNNT---DFKQLYQTLTDYDIRFYMYEILK 142 + N+ITL D+ ++ RT L+ E V+ DF ++L++ + ++ +IL Sbjct: 71 QVLH-HNVITLHDVYEN---RTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILD 126 Query: 143 ALDYCHSMGIMHRDVKPHNVMIDHEHR---KLRLIDWGLAEFYHPGQEYNVRVASRYFKG 199 ++Y H+ I H D+KP N+M+ ++ ++LID+GLA G E+ + F Sbjct: 127 GVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVA 186 Query: 200 PELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYID 259 PE +V+Y+ DMWS+G + ++ PF G + L I V YD+ + Sbjct: 187 PE-IVNYEPLGLEADMWSIGVITYILLSGASPFL-GDTKQETLANITAV-----SYDFDE 239 Query: 260 KYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAM 319 ++ S+ L A DF+ KLL + + RLT +EA+ Sbjct: 240 EF------------------------FSQTSEL----AKDFIRKLLVKETRKRLTIQEAL 271 Query: 320 EHPYFYTVVKDQARMGSSSM 339 HP+ V QA + S+ Sbjct: 272 RHPWITPVDNQQAMVRRESV 291 >2QNJ-A nrPDB Length = 328 Score = 86.7 bits (213), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 53/203 (26%), Positives = 110/203 (54%), Gaps = 12/203 (5%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKI-----LKPVKKKKIKREIKILENLRGGP 92 +Y+L++ +G+G +++V A +I +V +KI L P +K+ RE++I++ L P Sbjct: 13 NYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKIL-NHP 71 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNT---DFKQLYQTLTDYDIRFYMYEILKALDYCHS 149 NI+ L ++++ +T L+ E+ + D+ + + + + R +I+ A+ YCH Sbjct: 72 NIVKLFEVIE--TEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQ 129 Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMY 209 I+HRD+K N+++D + +++ D+G + + G + + S + PEL + Sbjct: 130 KRIVHRDLKAENLLLDADM-NIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYD 188 Query: 210 DYSLDMWSLGCMLASMIFRKEPF 232 +D+WSLG +L +++ PF Sbjct: 189 GPEVDVWSLGVILYTLVSGSLPF 211 >4UZD-A nrPDB Length = 287 Score = 86.7 bits (213), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 67/255 (26%), Positives = 126/255 (49%), Gaps = 25/255 (9%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK------IKREIKILENLRG 90 +D+++ R LG+GK+ V+ A + + +K+L + +K ++RE++I +LR Sbjct: 8 EDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRH 67 Query: 91 GPNIITLADIVKDPVSRTPALVFEHVN-NTDFKQLYQTLTDYD---IRFYMYEILKALDY 146 PNI+ L D L+ E+ T +++L Q L+ +D Y+ E+ AL Y Sbjct: 68 -PNILRLYGYFHDATR--VYLILEYAPLGTVYREL-QKLSKFDEQRTATYITELANALSY 123 Query: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDY 206 CHS ++HRD+KP N+++ +L++ D+G + + P + + PE +++ Sbjct: 124 CHSKRVIHRDIKPENLLLGSAG-ELKIADFGWS-VHAPSSRRTTLCGTLDYLPPE-MIEG 180 Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHG--HDNYDQLVRIAKVL------GTEDLYDYI 258 +M+D +D+WSLG + + K PF + Y ++ R+ G DL + Sbjct: 181 RMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRL 240 Query: 259 DKYNIELDPRFNDIL 273 K+N P ++L Sbjct: 241 LKHNPSQRPMLREVL 255 >5UNP-A nrPDB Length = 369 Score = 86.7 bits (213), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 83/333 (24%), Positives = 157/333 (47%), Gaps = 44/333 (13%) Query: 29 HVVEWGNQDDYQLVRKLGRGKYSEVFEAIN-ITNNEKVVVKILKPVKKKK--IKREIKIL 85 HV +W Q+ Y++V LG G + V + ++ +V +KI+K V+K K + EI +L Sbjct: 27 HVGDWL-QERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVL 85 Query: 86 ENL-RGGPNIITLADIVKDPVSRTP--ALVFEHVNNTDFKQL----YQTLTDYDIRFYMY 138 E + P+ L + D + FE + + F L Y + +R + Sbjct: 86 EKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAF 145 Query: 139 EILKALDYCHSMGIMHRDVKPHNVMI---DHE---------------HRKLRLIDWGLAE 180 ++ +A+ + H + H D+KP N++ D+E +R++D+G A Sbjct: 146 QLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSAT 205 Query: 181 FYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYD 240 F H + ++ V++R+++ PE++++ + D+WS+GC++ + F HDN + Sbjct: 206 FDH--EHHSTIVSTRHYRAPEVILELG-WSQPCDVWSIGCIIFEY-YVGFTLFQTHDNRE 261 Query: 241 QLVRIAKVLGT--EDLYDYIDK----YNIELDPRFNDILGRHSRKRWE---RFVHSENQH 291 L + ++LG + K Y LD N GR+ R+ + R++ SE + Sbjct: 262 HLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEE 321 Query: 292 LVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 + D ++ +L Y+ RLT EA++HP+F Sbjct: 322 --HHQLFDLIESMLEYEPAKRLTLGEALQHPFF 352 >2HAK-A nrPDB Length = 328 Score = 86.3 bits (212), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 54/203 (26%), Positives = 109/203 (53%), Gaps = 12/203 (5%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKI-----LKPVKKKKIKREIKILENLRGGP 92 +Y+L + +G+G +++V A ++ +V VKI L P +K+ RE++I++ L P Sbjct: 16 NYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKIL-NHP 74 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNT---DFKQLYQTLTDYDIRFYMYEILKALDYCHS 149 NI+ L ++++ +T LV E+ + D+ + + + + R +I+ A+ YCH Sbjct: 75 NIVKLFEVIE--TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQ 132 Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMY 209 I+HRD+K N+++D + +++ D+G + + G + + S + PEL + Sbjct: 133 KYIVHRDLKAENLLLDGDM-NIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYD 191 Query: 210 DYSLDMWSLGCMLASMIFRKEPF 232 +D+WSLG +L +++ PF Sbjct: 192 GPEVDVWSLGVILYTLVSGSLPF 214 >3Q5I-A nrPDB Length = 504 Score = 86.3 bits (212), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 86/354 (24%), Positives = 155/354 (43%), Gaps = 69/354 (19%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK----------------IKR 80 + Y VRKLG G Y EV + + +K++K + K I Sbjct: 36 ESYFKVRKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYSDDNKNIEKFHEEIYN 95 Query: 81 EIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTD-FKQLYQ--TLTDYDIRFYM 137 EI +L++L PNII L D+ +D + LV E + F+Q+ + D M Sbjct: 96 EISLLKSL-DHPNIIKLFDVFEDK--KYFYLVTEFYEGGELFEQIINRHKFDECDAANIM 152 Query: 138 YEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKL--RLIDWGLAEFYHPGQEYNVRVASR 195 +IL + Y H I+HRD+KP N+++++++ L +++D+GL+ F+ + R+ + Sbjct: 153 KQILSGICYLHKHNIVHRDIKPENILLENKNSLLNIKIVDFGLSSFFSKDYKLRDRLGTA 212 Query: 196 YFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLY 255 Y+ PE+L + Y+ D+WS G ++ ++ P F G ++ D + ++ K Sbjct: 213 YYIAPEVLK--KKYNEKCDVWSCGVIMYILLCGYPP-FGGQNDQDIIKKVEK-------- 261 Query: 256 DYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTA 315 KY + FND W+ +S EA + + +L YD+ R TA Sbjct: 262 ---GKYYFD----FND---------WKN---------ISDEAKELIKLMLTYDYNKRCTA 296 Query: 316 REAMEHPYFYTVVKDQARMGSSSMPG---------GSTPVSSANMMSGISSVPT 360 EA+ + + + ++ G GS ++ A ++ S + T Sbjct: 297 EEALNSRWIKKYANNINKSDQKTLCGALSNMRKFEGSQKLAQAAILFIGSKLTT 350 >6CMJ-A nrPDB Length = 321 Score = 86.3 bits (212), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 63/218 (28%), Positives = 109/218 (50%), Gaps = 25/218 (11%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKR---------------- 80 D Y L ++G+G Y V A N +N +K+L KKK I++ Sbjct: 34 DQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLS--KKKLIRQAGGCIQPRGPIEQVYQ 91 Query: 81 EIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQL--YQTLTDYDIRFYMY 138 EI IL+ L PN++ L +++ DP +VFE VN ++ + L++ RFY Sbjct: 92 EIAILKKL-DHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQ 150 Query: 139 EILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYNVRVASRYF 197 +++K ++Y H I+HRD+KP N+++ E +++ D+G++ EF + V + F Sbjct: 151 DLIKGIEYLHYQKIIHRDIKPSNLLVG-EDGHIKIADFGVSNEFKGSDALLSNTVGTPAF 209 Query: 198 KGPELLVDYQ--MYDYSLDMWSLGCMLASMIFRKEPFF 233 PE L + + +LD+W++G L +F + PF Sbjct: 210 MAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFM 247 >4FG9-A nrPDB Length = 320 Score = 86.3 bits (212), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 78/300 (26%), Positives = 140/300 (46%), Gaps = 51/300 (17%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPV----KKKKIKREIKILENLRGG 91 +D Y LG G +SEV A + + V +K + K+ ++ EI +L ++ Sbjct: 17 RDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMENEIAVLHKIKH- 75 Query: 92 PNIITLADIVKDPVSRTPALVFEHVNNTD-FKQLYQT--LTDYDIRFYMYEILKALDYCH 148 PNI+ L DI + L+ + V+ + F ++ + T+ D ++++L A+ Y H Sbjct: 76 PNIVALDDIYES--GGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLH 133 Query: 149 SMGIMHRDVKPHNVM---IDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVD 205 +GI+HRD+KP N++ +D E K+ + D+GL++ PG + + + PE+L Sbjct: 134 DLGIVHRDLKPENLLYYSLD-EDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEVLAQ 192 Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIEL 265 + Y ++D WS+G + ++ PF+ +D AK L++ I K E Sbjct: 193 -KPYSKAVDCWSIGVIAYILLCGYPPFYDEND--------AK------LFEQILKAEYEF 237 Query: 266 D-PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 D P ++DI S A DF+ L+ D + R T +A++HP+ Sbjct: 238 DSPYWDDI---------------------SDSAKDFIRHLMEKDPEKRFTCEQALQHPWI 276 >3GUB-A nrPDB Length = 295 Score = 86.3 bits (212), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 81/322 (25%), Positives = 148/322 (45%), Gaps = 54/322 (16%) Query: 35 NQDDY-QLVRKLGRGKYSEVFEAINITNNEKVVVKILKP---------VKKKKIKREIKI 84 N DDY +LG G+++ V + + + K +K V ++ I+RE+ I Sbjct: 8 NVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSI 67 Query: 85 LENLRGGPNIITLADIVKDPVSRTPALVFEHVNNT---DFKQLYQTLTDYDIRFYMYEIL 141 L+ ++ PN+ITL ++ ++ L+ E V DF ++LT+ + ++ +IL Sbjct: 68 LKEIQH-PNVITLHEVYENKTDVI--LIGELVAGGELFDFLAEKESLTEEEATEFLKQIL 124 Query: 142 KALDYCHSMGIMHRDVKPHNVMIDHEHR---KLRLIDWGLAEFYHPGQEYNVRVASRYFK 198 + Y HS+ I H D+KP N+M+ + ++++ID+GLA G E+ + F Sbjct: 125 NGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFV 184 Query: 199 GPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYI 258 PE +V+Y+ DMWS+G + ++ PF G + L ++ V Y++ Sbjct: 185 APE-IVNYEPLGLEADMWSIGVITYILLSGASPFL-GDTKQETLANVSAV-----NYEFE 237 Query: 259 DKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREA 318 D+Y F++ S A DF+ +LL D + R+T +++ Sbjct: 238 DEY-------FSN---------------------TSALAKDFIRRLLVKDPKKRMTIQDS 269 Query: 319 MEHPYFYTVVKDQARMGSSSMP 340 ++HP+ QA + S P Sbjct: 270 LQHPWIKPKDTQQALSSAWSHP 291 >4CFF-A nrPDB Length = 571 Score = 85.9 bits (211), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 61/203 (30%), Positives = 99/203 (48%), Gaps = 13/203 (6%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK------KIKREIKILENLRGGP 92 Y L LG G + +V + KV VKIL K + KIKREI+ L+ R P Sbjct: 35 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH-P 93 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNT---DFKQLYQTLTDYDIRFYMYEILKALDYCHS 149 +II L ++ P +V E+V+ D+ + + + + R +IL A+DYCH Sbjct: 94 HIIKLYQVISTPTDFF--MVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHR 151 Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMY 209 ++HRD+KP NV++D H ++ D+GL+ G+ S + PE++ Sbjct: 152 HMVVHRDLKPENVLLD-AHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYA 210 Query: 210 DYSLDMWSLGCMLASMIFRKEPF 232 +D+WS G +L +++ PF Sbjct: 211 GPEVDIWSCGVILYALLCGTLPF 233 >4PDS-A nrPDB Length = 347 Score = 85.9 bits (211), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 78/308 (25%), Positives = 134/308 (43%), Gaps = 58/308 (18%) Query: 38 DYQLVRKL-GRGKYSEVFEAINITNNEKVVVKILKPVK----KKKIKREIKILENLRGGP 92 D+ ++ ++ G+G ++ V +AI T + VKI+ K + RE+++L+ L P Sbjct: 31 DFSIIDEVVGQGAFATVKKAIERTTGKTFSVKIISKRKVIGNMDGVTRELEVLQKLNH-P 89 Query: 93 NIITLADIVKDPVSRTPALVFEHVNN---TDFKQLYQTLTDYDIRFYMYEILKALDYCHS 149 I+ L +D + + +V E V+ DF + + + R +IL A+ Y HS Sbjct: 90 RIVRLKGFYED--TESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHS 147 Query: 150 MGIMHRDVKPHNVMIDHEHRKL-RLIDWGLAEFYHPGQEYNVRVASRYFKGPELL----- 203 MGI HRD+KP N++I+ + L ++ +GLA+ G + + PE++ Sbjct: 148 MGISHRDLKPDNILIEQDDPVLVKITAFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDT 207 Query: 204 -------VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYD 256 + Y +DMWS+GC++ ++ PF DQ LY Sbjct: 208 SVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPF--SGSTQDQ------------LYK 253 Query: 257 YIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAR 316 I + + P +S EA DF+D LL+ D +R TA Sbjct: 254 QIGRGSYHEGPL--------------------KDFRISEEARDFIDSLLQVDPNNRSTAA 293 Query: 317 EAMEHPYF 324 +A+ HP+ Sbjct: 294 KALNHPWI 301 >3ORZ-A nrPDB Length = 316 Score = 85.9 bits (211), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 79/311 (25%), Positives = 138/311 (44%), Gaps = 63/311 (20%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP---VKKKKI---KREIKILENLRG 90 +D++ + LG G +S V A + + + +KIL+ +K+ K+ RE ++ L Sbjct: 37 EDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRL-D 95 Query: 91 GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYD---IRFYMYEILKALDYC 147 P + L +D L + N + + + + +D RFY EI+ AL+Y Sbjct: 96 HPFFVKLYFCFQDDEKLYFGL--SYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYL 153 Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEY---NVRVASRYFKGPELLV 204 H GI+HRD+KP N++++ E +++ D+G A+ P + N V + + PELL Sbjct: 154 HGKGIIHRDLKPENILLN-EDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLT 212 Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIE 264 + S D+W+LGC++ ++ PF G ++ + K++ E YD+ +K+ Sbjct: 213 EKSACKSS-DLWALGCIIYQLVAGLPPFRAG----NEYLIFQKIIKLE--YDFPEKF--- 262 Query: 265 LDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAME---- 320 P+A D ++KLL D RL E ME Sbjct: 263 -----------------------------FPKARDLVEKLLVLDATKRLGCEE-MEGYGP 292 Query: 321 ---HPYFYTVV 328 HP+F +V Sbjct: 293 LKAHPFFESVT 303 >2WO6-A nrPDB Length = 382 Score = 85.9 bits (211), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 89/335 (26%), Positives = 162/335 (48%), Gaps = 59/335 (17%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK--KKIKREIKILENLRGGPNI 94 D Y++ +G+G + +V +A + E V +KI+K K + + E+++LE + Sbjct: 54 DRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTE 113 Query: 95 IT--LADIVKDPVSRT-PALVFEHVN--------NTDFKQLYQTLTDYDIRFYMYEILKA 143 + + + + + R LVFE ++ NT+F+ + LT R + ++ A Sbjct: 114 MKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLT----RKFAQQMCTA 169 Query: 144 LDYCHS--MGIMHRDVKPHNVMIDHEHRK-LRLIDWGLAEFYHPGQEYNVRVASRYFKGP 200 L + + + I+H D+KP N+++ + R ++++D+G + GQ + SR+++ P Sbjct: 170 LLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSS--CQLGQRIYQYIQSRFYRSP 227 Query: 201 ELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGT--------- 251 E+L+ YD ++DMWSLGC+L M EP F G + DQ+ +I +VLG Sbjct: 228 EVLLGMP-YDLAIDMWSLGCILVEM-HTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQA 285 Query: 252 -------EDLYDYIDKYNI--------ELDP----RFNDILGRHSRKRWERFVHSENQHL 292 E L D +N+ E P + ++ILG + R E+ H Sbjct: 286 PKARKFFEKLPD--GTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRA-GESGHT 342 Query: 293 VSPEALDFLDKLLR---YDHQSRLTAREAMEHPYF 324 V+ + L F D +LR YD ++R+ A++H +F Sbjct: 343 VA-DYLKFKDLILRMLDYDPKTRIQPYYALQHSFF 376 >3UTO-A nrPDB Length = 573 Score = 85.5 bits (210), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 83/345 (24%), Positives = 149/345 (43%), Gaps = 61/345 (17%) Query: 37 DDYQLVRKLGRGKYSEVFEAIN-ITNNEKVVVKILKP--VKKKKIKREIKILENLRGGPN 93 D Y + +LG G + V T N ++ P K+ +++EI+ + LR P Sbjct: 157 DHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKETVRKEIQTMSVLRH-PT 215 Query: 94 IITLADIVKDPVSRTPALVFEHVNNTD-FKQL---YQTLTDYDIRFYMYEILKALDYCHS 149 ++ L D +D +++E ++ + F+++ + +++ + YM ++ K L + H Sbjct: 216 LVNLHDAFED--DNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMRQVCKGLCHMHE 273 Query: 150 MGIMHRDVKPHNVMIDHEH-RKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQM 208 +H D+KP N+M + +L+LID+GL P Q V + F PE + + + Sbjct: 274 NNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTTGTAEFAAPE-VAEGKP 332 Query: 209 YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPR 268 Y DMWS+G + ++ PF G +N D+ +R K +N++ D Sbjct: 333 VGYYTDMWSVGVLSYILLSGLSPF--GGENDDETLRNVKSC----------DWNMD-DSA 379 Query: 269 FNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVV 328 F+ I S + DF+ KLL D +R+T +A+EHP+ Sbjct: 380 FSGI---------------------SEDGKDFIRKLLLADPNTRMTIHQALEHPW----- 413 Query: 329 KDQARMGSSSMPGGSTPVSSANMMSGISSVPT-----PSPLGPLA 368 + + PG + + S+ S+ T P PL PL Sbjct: 414 -----LTPGNAPGRDSQIPSSRYTKIRDSIKTKYDAWPEPLPPLG 453 >5EZV-A nrPDB Length = 560 Score = 85.5 bits (210), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 61/203 (30%), Positives = 99/203 (48%), Gaps = 13/203 (6%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK------KIKREIKILENLRGGP 92 Y L LG G + +V + KV VKIL K + KIKREI+ L+ R P Sbjct: 30 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH-P 88 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNT---DFKQLYQTLTDYDIRFYMYEILKALDYCHS 149 +II L ++ P +V E+V+ D+ + + + + R +IL A+DYCH Sbjct: 89 HIIKLYQVISTPTDFF--MVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHR 146 Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMY 209 ++HRD+KP NV++D H ++ D+GL+ G+ S + PE++ Sbjct: 147 HMVVHRDLKPENVLLD-AHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYA 205 Query: 210 DYSLDMWSLGCMLASMIFRKEPF 232 +D+WS G +L +++ PF Sbjct: 206 GPEVDIWSCGVILYALLCGTLPF 228 >5WAX-A nrPDB Length = 310 Score = 85.5 bits (210), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 71/294 (24%), Positives = 134/294 (45%), Gaps = 41/294 (13%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK--KKIKREIKILENLRGGPNI 94 D Y+LVR +G G + N + + V VK ++ +K + ++REI +LR PNI Sbjct: 11 DRYELVRDIGSGNFGVARLMRNRADGQLVAVKYIERGEKIDENVQREIINHRSLRH-PNI 69 Query: 95 ITLADIVKDPVSRTPALVFEHVNNTD-FKQLYQT--LTDYDIRFYMYEILKALDYCHSMG 151 I +++ P A+V E+ + + F+++ ++ + RF+ +++ + YCHSM Sbjct: 70 IRFKEVILTPTHL--AIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHSMQ 127 Query: 152 IMHRDVKPHNVMIDHEHR-KLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYD 210 + HRD+K N ++D +L++ D+G ++ + V + + PE+L+ + Sbjct: 128 VCHRDLKLENTLLDGSTAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDG 187 Query: 211 YSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFN 270 D+WS G L M+ PF + + I ++LG + Y+I Sbjct: 188 KVADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRILGVQ--------YSI------- 232 Query: 271 DILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 +VH +SPE D + ++ + +R+T E HP+F Sbjct: 233 -----------PDYVH------ISPECQDLISRIFVANPATRITIPEIRNHPWF 269 >6C9D-A nrPDB Length = 459 Score = 85.5 bits (210), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 54/203 (26%), Positives = 109/203 (53%), Gaps = 12/203 (5%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKI-----LKPVKKKKIKREIKILENLRGGP 92 +Y+L + +G+G +++V A ++ +V VKI L P +K+ RE++I++ L P Sbjct: 22 NYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKIL-NHP 80 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNT---DFKQLYQTLTDYDIRFYMYEILKALDYCHS 149 NI+ L ++++ +T LV E+ + D+ + + + + R +I+ A+ YCH Sbjct: 81 NIVKLFEVIE--TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQ 138 Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMY 209 I+HRD+K N+++D + +++ D+G + + G + + S + PEL + Sbjct: 139 KYIVHRDLKAENLLLDGDM-NIKIADFGFSNEFTVGNKLDEFCGSPPYAAPELFQGKKYD 197 Query: 210 DYSLDMWSLGCMLASMIFRKEPF 232 +D+WSLG +L +++ PF Sbjct: 198 GPEVDVWSLGVILYTLVSGSLPF 220 >1KOA-A nrPDB Length = 491 Score = 85.1 bits (209), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 83/345 (24%), Positives = 149/345 (43%), Gaps = 61/345 (17%) Query: 37 DDYQLVRKLGRGKYSEVFEAIN-ITNNEKVVVKILKP--VKKKKIKREIKILENLRGGPN 93 D Y + +LG G + V T N ++ P K+ +++EI+ + LR P Sbjct: 51 DHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKETVRKEIQTMSVLRH-PT 109 Query: 94 IITLADIVKDPVSRTPALVFEHVNNTD-FKQL---YQTLTDYDIRFYMYEILKALDYCHS 149 ++ L D +D +++E ++ + F+++ + +++ + YM ++ K L + H Sbjct: 110 LVNLHDAFED--DNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMRQVCKGLCHMHE 167 Query: 150 MGIMHRDVKPHNVMIDHEH-RKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQM 208 +H D+KP N+M + +L+LID+GL P Q V + F PE + + + Sbjct: 168 NNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTTGTAEFAAPE-VAEGKP 226 Query: 209 YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPR 268 Y DMWS+G + ++ PF G +N D+ +R K +N++ D Sbjct: 227 VGYYTDMWSVGVLSYILLSGLSPF--GGENDDETLRNVKSC----------DWNMD-DSA 273 Query: 269 FNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVV 328 F+ I S + DF+ KLL D +R+T +A+EHP+ Sbjct: 274 FSGI---------------------SEDGKDFIRKLLLADPNTRMTIHQALEHPW----- 307 Query: 329 KDQARMGSSSMPGGSTPVSSANMMSGISSVPT-----PSPLGPLA 368 + + PG + + S+ S+ T P PL PL Sbjct: 308 -----LTPGNAPGRDSQIPSSRYTKIRDSIKTKYDAWPEPLPPLG 347 >5KZ7-A nrPDB Length = 346 Score = 84.7 bits (208), Expect = 7e-17, Method: Compositional matrix adjust. Identities = 64/267 (23%), Positives = 136/267 (50%), Gaps = 20/267 (7%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK-----KKIKREIKILENLRGGP 92 +Y+L++ +G+G +++V A +I ++V VKI+ + +K+ RE++I++ L P Sbjct: 34 NYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVL-NHP 92 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNT---DFKQLYQTLTDYDIRFYMYEILKALDYCHS 149 NI+ L ++++ +T LV E+ + D+ + + + + R +I+ A+ YCH Sbjct: 93 NIVKLFEVIE--TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQ 150 Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMY 209 I+HRD+K N+++D + +++ D+G + + G + + S + PEL + Sbjct: 151 KFIVHRDLKAENLLLDAD-MNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYD 209 Query: 210 DYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAK------VLGTEDLYDYIDKYNI 263 +D+WSLG +L +++ P F G + + R+ + + D + + K+ I Sbjct: 210 GPEVDVWSLGVILYTLVSGSLP-FDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLI 268 Query: 264 ELDPRFNDILGRHSRKRWERFVHSENQ 290 L+P L + + RW H +++ Sbjct: 269 -LNPSKRGTLEQIMKDRWMNVGHEDDE 294 >4YZB-A nrPDB Length = 491 Score = 84.3 bits (207), Expect = 8e-17, Method: Compositional matrix adjust. Identities = 77/345 (22%), Positives = 153/345 (44%), Gaps = 65/345 (18%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGG----- 91 D Y+ R LG+G + EV + ++ VK+ + K+++K++ L+ Sbjct: 30 DRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKV---ISKRQVKQKTDKELLLKEVELLKK 86 Query: 92 ---PNIITLADIVKDP-----VSR--TPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEIL 141 PNI+ L + +D V+ T +F+ + + + ++ D + ++L Sbjct: 87 LDHPNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISR------KRFSEVDAARIIRQVL 140 Query: 142 KALDYCHSMGIMHRDVKPHNVMIDHEHR--KLRLIDWGLAEFYHPGQEYNVRVASRYFKG 199 + Y H I+HRD+KP N++++++ + +R+ID+GL+ + ++ ++ + Y+ Sbjct: 141 SGITYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIA 200 Query: 200 PELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYID 259 PE+L + YD D+WS G +L ++ P F+G + +D L ++ K T DL Sbjct: 201 PEVL--HGTYDEKCDVWSTGVILY-ILLSGCPPFNGANEFDILKKVEKGKFTFDL----- 252 Query: 260 KYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAM 319 +W++ VS A D + K+L Y R++AR+A+ Sbjct: 253 -------------------PQWKK---------VSEPAKDLIRKMLAYVPTMRISARDAL 284 Query: 320 EHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPL 364 EH + T A S +P + + + G + + L Sbjct: 285 EHEWLKTT---DAATDSIDVPSLESTILNIRQFQGTQKLAAAALL 326 >5FG8-A nrPDB Length = 285 Score = 84.3 bits (207), Expect = 8e-17, Method: Compositional matrix adjust. Identities = 75/301 (24%), Positives = 142/301 (47%), Gaps = 53/301 (17%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK-----KKIKREIKILENLRGG 91 D+Y + +LG+G +S V + + + KI+ K +K++RE +I L Sbjct: 14 DNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHH- 72 Query: 92 PNIITLADIVKDPVSRTPALVFEHVNNTD-FKQLY--QTLTDYDIRFYMYEILKALDYCH 148 PNI+ L D +++ LVF+ V + F+ + + ++ D + +IL+++++CH Sbjct: 73 PNIVRLHDSIQE--ENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCH 130 Query: 149 SMGIMHRDVKPHNVMIDHEHR--KLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLVD 205 G++HRD+KP N+++ + + ++L D+GLA E Q + + + PE+L Sbjct: 131 QNGVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVL-K 189 Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFF--HGHDNYDQLVRIAKVLGTEDLYDYIDKYNI 263 + Y S+D+W+ G +L ++ PF+ H Y Q+ A YDY Sbjct: 190 KEPYGKSVDIWACGVILYILLVGYPPFWDEDQHRLYSQIKAGA--------YDY------ 235 Query: 264 ELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323 W+ V+PEA + ++++L + R+TA EA++HP+ Sbjct: 236 -------------PSPEWD---------TVTPEAKNLINQMLTVNPNKRITAAEALKHPW 273 Query: 324 F 324 Sbjct: 274 I 274 >4CZT-A nrPDB Length = 464 Score = 84.0 bits (206), Expect = 9e-17, Method: Compositional matrix adjust. Identities = 60/207 (28%), Positives = 111/207 (53%), Gaps = 18/207 (8%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKIL---KPVKKK---KIKREIKILENLRGGP 92 Y+L R LG G +++V A N+ N + V +K++ K +K K +IKREI ++ ++ P Sbjct: 13 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH-P 71 Query: 93 NIITLADIVKDPVSRTPA-LVFEHVNNTD-FKQLYQT--LTDYDIRFYMYEILKALDYCH 148 N+I + +++ S+T V E V + F ++ L + + R Y +++ A+DYCH Sbjct: 72 NVIRMFEVM---ASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCH 128 Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE---YNVRVASRYFKGPELLVD 205 S G+ HRD+KP N+++D + L++ D+GL+ +E + + + PE++ + Sbjct: 129 SRGVYHRDLKPENLLLDA-NGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINN 187 Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPF 232 D+WS G +L ++ PF Sbjct: 188 KGYDGAKADLWSCGVILFVLMAGYLPF 214 >3SOA-A nrPDB Length = 444 Score = 84.0 bits (206), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 75/301 (24%), Positives = 141/301 (46%), Gaps = 53/301 (17%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK-----KKKIKREIKILENLRGG 91 ++YQL +LG+G +S V + + ++ I+ K +K++RE +I L+ Sbjct: 11 EEYQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDHQKLEREARICRLLKH- 69 Query: 92 PNIITLADIVKDPVSRTPALVFEHVNNTD-FKQLY--QTLTDYDIRFYMYEILKALDYCH 148 PNI+ L D + + L+F+ V + F+ + + ++ D + +IL+A+ +CH Sbjct: 70 PNIVRLHDSISEEGHHY--LIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCH 127 Query: 149 SMGIMHRDVKPHNVMIDHEHR--KLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLVD 205 MG++HR++KP N+++ + + ++L D+GLA E Q + + + PE+L Sbjct: 128 QMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRK 187 Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFF--HGHDNYDQLVRIAKVLGTEDLYDYIDKYNI 263 Y +D+W+ G +L ++ PF+ H Y Q+ A YD+ Sbjct: 188 -DPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGA--------YDF------ 232 Query: 264 ELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323 W+ V+PEA D ++K+L + R+TA EA++HP+ Sbjct: 233 -------------PSPEWD---------TVTPEAKDLINKMLTINPSKRITAAEALKHPW 270 Query: 324 F 324 Sbjct: 271 I 271 >4RLP-A nrPDB Length = 288 Score = 84.0 bits (206), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 80/307 (26%), Positives = 135/307 (43%), Gaps = 62/307 (20%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIIT 96 + ++L+R LG+G Y +VF+ +T + +K +KK I R K + + NI+ Sbjct: 5 ECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNIL- 63 Query: 97 LADIVKDP----------VSRTPALVFEHVNNTD-FKQLYQ--TLTDYDIRFYMYEILKA 143 + VK P L+ E+++ + F QL + + FY+ EI A Sbjct: 64 --EEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMA 121 Query: 144 LDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPEL 202 L + H GI++RD+KP N+M++H+ ++L D+GL E H G + + + PE+ Sbjct: 122 LGHLHQKGIIYRDLKPENIMLNHQGH-VKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEI 180 Query: 203 LVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYN 262 L+ ++ ++D WSLG ++ M+ PF +N + + D I K Sbjct: 181 LMR-SGHNRAVDWWSLGALMYDMLTGAPPF--TGENRKKTI------------DKILKCK 225 Query: 263 IELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT-----ARE 317 + L P ++ EA D L KLL+ + SRL A E Sbjct: 226 LNLPP------------------------YLTQEARDLLKKLLKRNAASRLGAGPGDAGE 261 Query: 318 AMEHPYF 324 HP+F Sbjct: 262 VQAHPFF 268 >3BHH-A nrPDB Length = 295 Score = 83.6 bits (205), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 75/300 (25%), Positives = 140/300 (46%), Gaps = 53/300 (17%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK-----KKKIKREIKILENLRGG 91 D+YQL +G+G +S V + + + KI+ K +K++RE +I L+ Sbjct: 4 DEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHS 63 Query: 92 PNIITLADIVKDPVSRTPALVFEHVNNTD-FKQLY--QTLTDYDIRFYMYEILKALDYCH 148 NI+ L D + + LVF+ V + F+ + + ++ D + +IL+A+ +CH Sbjct: 64 -NIVRLHDSISEEGFHY--LVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCH 120 Query: 149 SMGIMHRDVKPHNVMIDHEHR--KLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLVD 205 MG++HRD+KP N+++ + + ++L D+GLA E Q + + + PE+L Sbjct: 121 QMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRK 180 Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFF--HGHDNYDQLVRIAKVLGTEDLYDYIDKYNI 263 + Y +D+W+ G +L ++ PF+ H Y Q+ A YD+ Sbjct: 181 -EAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGA--------YDF------ 225 Query: 264 ELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323 W+ V+PEA + ++++L + R+TA EA++HP+ Sbjct: 226 -------------PSPEWDT---------VTPEAKNLINQMLTINPAKRITAHEALKHPW 263 >4L42-A nrPDB Length = 346 Score = 83.6 bits (205), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 80/305 (26%), Positives = 134/305 (43%), Gaps = 62/305 (20%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLA 98 ++L+R LG+G Y +VF+ +T + +K +KK I R K + + NI+ Sbjct: 20 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNIL--- 76 Query: 99 DIVKDP----------VSRTPALVFEHVNNTD-FKQLYQ--TLTDYDIRFYMYEILKALD 145 + VK P L+ E+++ + F QL + + FY+ EI AL Sbjct: 77 EEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALG 136 Query: 146 YCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLV 204 + H GI++RD+KP N+M++H+ ++L D+GL E H G + + + PE+L+ Sbjct: 137 HLHQKGIIYRDLKPENIMLNHQGH-VKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILM 195 Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIE 264 ++ ++D WSLG ++ M+ PF +N + + D I K + Sbjct: 196 -RSGHNRAVDWWSLGALMYDMLTGAPPF--TGENRKKTI------------DKILKCKLN 240 Query: 265 LDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT-----AREAM 319 L P ++ EA D L KLL+ + SRL A E Sbjct: 241 LPP------------------------YLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQ 276 Query: 320 EHPYF 324 HP+F Sbjct: 277 AHPFF 281 >2BDW-A nrPDB Length = 362 Score = 83.2 bits (204), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 73/301 (24%), Positives = 141/301 (46%), Gaps = 54/301 (17%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK-----KKIKREIKILENLRGG 91 D+Y + +LG+G +S V ++ T + KI+ K +K++RE +I L+ Sbjct: 29 DNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQH- 87 Query: 92 PNIITLADIVKDPVSRTPALVFEHVNNTDF------KQLYQTLTDYDIRFYMYEILKALD 145 PNI+ L D +++ LVF+ V + ++ Y ++ D + +IL+++ Sbjct: 88 PNIVRLHDSIQEESFHY--LVFDLVTGGELFEDIVAREFY---SEADASHCIQQILESIA 142 Query: 146 YCHSMGIMHRDVKPHNVMIDHEHR--KLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELL 203 YCHS GI+HR++KP N+++ + + ++L D+GLA + + ++ + + PE+L Sbjct: 143 YCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVL 202 Query: 204 VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNI 263 Y +D+W+ G +L ++ PF+ + DQ A++ YDY Sbjct: 203 -KKDPYSKPVDIWACGVILYILLVGYPPFW----DEDQHRLYAQI--KAGAYDY------ 249 Query: 264 ELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323 W+ V+PEA +D +L + + R+TA +A++ P+ Sbjct: 250 -------------PSPEWD---------TVTPEAKSLIDSMLTVNPKKRITADQALKVPW 287 Query: 324 F 324 Sbjct: 288 I 288 >2JC6-A nrPDB Length = 334 Score = 83.2 bits (204), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 77/296 (26%), Positives = 132/296 (44%), Gaps = 49/296 (16%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKIL--KPVKKKK--IKREIKILENLRGGPNI 94 ++ LG G +SEV A + VK + K +K K+ I+ EI +L ++ NI Sbjct: 24 FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKH-ENI 82 Query: 95 ITLADIVKDPVSRTPALVFEHVNNTD-FKQLYQT--LTDYDIRFYMYEILKALDYCHSMG 151 + L DI + P LV + V+ + F ++ + T+ D + ++L A+ Y H MG Sbjct: 83 VALEDIYESP--NHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMG 140 Query: 152 IMHRDVKPHNVMI--DHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMY 209 I+HRD+KP N++ E K+ + D+GL++ G + + + PE+L + Y Sbjct: 141 IVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQ-KPY 199 Query: 210 DYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD-PR 268 ++D WS+G + ++ PF+ +D+ L++ I K E D P Sbjct: 200 SKAVDCWSIGVIAYILLCGYPPFYDENDS--------------KLFEQILKAEYEFDSPY 245 Query: 269 FNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 ++DI S A DF+ L+ D R T +A HP+ Sbjct: 246 WDDI---------------------SDSAKDFIRNLMEKDPNKRYTCEQAARHPWI 280 >4RGJ-A nrPDB Length = 520 Score = 83.2 bits (204), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 75/304 (24%), Positives = 147/304 (48%), Gaps = 59/304 (19%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL--KPVKKKKIK----REIKILENLRG 90 + Y+ ++ LG+G + EV + + + +K++ K VK+K K RE+++L+ L Sbjct: 60 EQYKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKESLLREVELLKML-D 118 Query: 91 GPNIITLADIVKDP-----VSR--TPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKA 143 NI+ L + +D VS T +F+ + K+ Y+ D + +IL Sbjct: 119 HINIMKLYEFFEDNNYYYLVSDVYTGGELFDEI--ISRKRFYEI----DAARIIKQILSG 172 Query: 144 LDYCHSMGIMHRDVKPHNVMIDHEHRK---LRLIDWGLAEFYHPGQEYNVRVASRYFKGP 200 + Y H ++HRD+KP N++++ ++++ +++ID+GL+ + ++ ++ + Y+ P Sbjct: 173 ITYMHKNNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHFEYSKKMKDKIGTAYYIAP 232 Query: 201 ELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDK 260 ++L + YD D+WS G +L ++ P F+G + YD L ++ K Sbjct: 233 DVL--HGTYDEKCDIWSCGVILY-ILLSGCPPFNGSNEYDILKKVEA-----------GK 278 Query: 261 YNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAME 320 Y +L P+F I S +A D + K+L Y R++AR+A+E Sbjct: 279 YTFDL-PQFKKI---------------------SDKAKDLIKKMLMYTSAVRISARDALE 316 Query: 321 HPYF 324 H + Sbjct: 317 HEWI 320 >2YZA-A nrPDB Length = 276 Score = 82.8 bits (203), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 61/203 (30%), Positives = 99/203 (48%), Gaps = 13/203 (6%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK------KIKREIKILENLRGGP 92 Y L LG G + +V + KV VKIL K + KIKREI+ L+ R P Sbjct: 13 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH-P 71 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNT---DFKQLYQTLTDYDIRFYMYEILKALDYCHS 149 +II L ++ P +V E+V+ D+ + + + + R +IL A+DYCH Sbjct: 72 HIIKLYQVISTPTDFF--MVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHR 129 Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMY 209 ++HRD+KP NV++D H ++ D+GL+ G+ S + PE++ Sbjct: 130 HMVVHRDLKPENVLLD-AHMNAKIADFGLSNMMSDGEFLRDSCGSPNYAAPEVISGRLYA 188 Query: 210 DYSLDMWSLGCMLASMIFRKEPF 232 +D+WS G +L +++ PF Sbjct: 189 GPEVDIWSCGVILYALLCGTLPF 211 >4D2V-A nrPDB Length = 356 Score = 82.4 bits (202), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 71/295 (24%), Positives = 134/295 (45%), Gaps = 51/295 (17%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP----VKKKKIKREIKILENLRGGPNI 94 Y+L +G G +++V A +I E V +KI+ +IK EI+ L+NLR +I Sbjct: 31 YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNLRH-QHI 89 Query: 95 ITLADIVKDPVSRTPALVFEHVNNT---DFKQLYQTLTDYDIRFYMYEILKALDYCHSMG 151 L +++ + +V E+ D+ L++ + R +I+ A+ Y HS G Sbjct: 90 CQLYHVLE--TANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQG 147 Query: 152 IMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVR--VASRYFKGPELLVDYQMY 209 HRD+KP N++ D E+ KL+LID+GL ++Y+++ + + PEL+ Sbjct: 148 YAHRDLKPENLLFD-EYHKLKLIDFGLCAKPKGNKDYHLQACCGALAYAAPELIQGKSYL 206 Query: 210 DYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRF 269 D+WS+G +L ++ PF D+ +AK++ Sbjct: 207 GSEADVWSMGILLYVLMCGFLPF----DDDTAAALVAKIMR------------------- 243 Query: 270 NDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 G++ +W +SP ++ L ++L+ D + R++ + + HP+ Sbjct: 244 ----GKYDVPKW-----------LSPSSILLLQQMLQVDPKKRISMKNLLNHPWI 283 >3RAW-A nrPDB Length = 381 Score = 82.4 bits (202), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 82/343 (23%), Positives = 156/343 (45%), Gaps = 52/343 (15%) Query: 25 DYESHVV----EWGNQDDYQLVRKLGRGKYSEVFEAIN-ITNNEKVVVKILKPVKK--KK 77 D E H+V +W Q+ Y++V LG G + +V E ++ +V +KI++ V K + Sbjct: 36 DKEGHLVCRIGDWL-QERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREA 94 Query: 78 IKREIKILENLRGGPN-----IITLADIVKDPVSRTPALVFEHVNNTDFKQL----YQTL 128 + EI +L+ ++ + ++D + FE + F+ L +Q Sbjct: 95 ARLEINVLKKIKEKDKENKFLCVLMSDWFN--FHGHMCIAFELLGKNTFEFLKENNFQPY 152 Query: 129 TDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVM--------IDHEHR----------K 170 +R Y++ AL + H + H D+KP N++ + +EH+ Sbjct: 153 PLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTS 212 Query: 171 LRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKE 230 +R+ D+G A F H + + VA+R+++ PE++++ + D+WS+GC+L +R Sbjct: 213 IRVADFGSATFDH--EHHTTIVATRHYRPPEVILELG-WAQPCDVWSIGCILFEY-YRGF 268 Query: 231 PFFHGHDNYDQLVRIAKVLG--------TEDLYDYIDKYNIELDPRFNDILGRHSRKRWE 282 F H+N + LV + K+LG Y K + D +D GR+ ++ + Sbjct: 269 TLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSD--GRYVKENCK 326 Query: 283 RF-VHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 + L + D + ++L +D R+T EA+ HP+F Sbjct: 327 PLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFF 369 >3KK8-A nrPDB Length = 284 Score = 82.0 bits (201), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 73/298 (24%), Positives = 142/298 (47%), Gaps = 48/298 (16%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK-----KKIKREIKILENLRGG 91 D+Y + +LG+G +S V ++ T + KI+ K +K++RE +I L+ Sbjct: 6 DNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQH- 64 Query: 92 PNIITLADIVKDPVSRTPALVFEHVNNTD-FKQLY--QTLTDYDIRFYMYEILKALDYCH 148 PNI+ L D +++ LVF+ V + F+ + + ++ D + +IL+++ YCH Sbjct: 65 PNIVRLHDSIQEESFHY--LVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCH 122 Query: 149 SMGIMHRDVKPHNVMIDHEHR--KLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDY 206 S GI+HR++KP N+++ + + ++L D+GLA + + ++ + + PE+L Sbjct: 123 SNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVL-KK 181 Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 266 Y +D+W+ G +L ++ PF+ + DQ A++ YDY Sbjct: 182 DPYSKPVDIWACGVILYILLVGYPPFW----DEDQHRLYAQIKAGA--YDY--------- 226 Query: 267 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 W+ V+PEA +D +L + + R+TA +A++ P+ Sbjct: 227 ----------PSPEWDT---------VTPEAKSLIDSMLTVNPKKRITADQALKVPWI 265 >5X8I-B nrPDB Length = 346 Score = 81.6 bits (200), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 81/335 (24%), Positives = 149/335 (44%), Gaps = 67/335 (20%) Query: 39 YQLVRKLGRGKYSEVFEAIN-ITNNEKVVVKILKPVKK--KKIKREIKILENLRGGPNII 95 Y++V LG G + +V E I+ V VKI+K V + + + EI++LE+L Sbjct: 15 YEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLN------ 68 Query: 96 TLADIVKDPVS--RTPALV--FEHVNNTDFKQLYQTLTDYD--------------IRFYM 137 DP S R ++ FEH + L+ YD IR Sbjct: 69 -----TTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMA 123 Query: 138 YEILKALDYCHSMGIMHRDVKPHNVM-------------IDHEHRKL-----RLIDWGLA 179 Y+I K++++ HS + H D+KP N++ I + R L +++D+G A Sbjct: 124 YQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSA 183 Query: 180 EFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNY 239 + + ++ V++R+++ PE+++ + D+WS+GC+L + F HD+ Sbjct: 184 TY--DDEHHSTLVSTRHYRAPEVILALG-WSQPCDVWSIGCILIEY-YLGFTVFPTHDSK 239 Query: 240 DQLVRIAKVLG----------TEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSEN 289 + L + ++LG + Y + D+ + + + R + E + + Sbjct: 240 EHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQDV 299 Query: 290 QHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 +H D + K+L YD R+T REA++HP+F Sbjct: 300 EH---ERLFDLIQKMLEYDPAKRITLREALKHPFF 331 >4WNO-A nrPDB Length = 287 Score = 81.6 bits (200), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 58/212 (27%), Positives = 109/212 (51%), Gaps = 22/212 (10%) Query: 39 YQLVRK--LGRGKYSEVFEAIN-ITNNEKVVVKIL--KPVKKKK--IKREIKILENLRGG 91 ++ RK +G G ++ VF+ + ++ +V VK + K + K + + +EIKIL+ L+ Sbjct: 18 FEFSRKDLIGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKH- 76 Query: 92 PNIITLADIVKDPVSRTPALVFEHVNN---TDFKQLYQTLTDYDIRFYMYEILKALDYCH 148 NI+ L D ++ + LV E+ N D+ +TL++ IR ++ +I A+ H Sbjct: 77 ENIVALYDF--QEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLH 134 Query: 149 SMGIMHRDVKPHNVMIDH--------EHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGP 200 S GI+HRD+KP N+++ + ++++ D+G A + S + P Sbjct: 135 SKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAP 194 Query: 201 ELLVDYQMYDYSLDMWSLGCMLASMIFRKEPF 232 E+++ Q YD D+WS+G ++ + K PF Sbjct: 195 EVIMS-QHYDGKADLWSIGTIVYQCLTGKAPF 225 >2W4O-A nrPDB Length = 349 Score = 81.6 bits (200), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 79/293 (26%), Positives = 135/293 (46%), Gaps = 43/293 (14%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK-PVKKKKIKREIKILENLRGGPNII 95 D +++ +LGRG S V+ + +K+LK V KK ++ EI +L L PNII Sbjct: 53 DFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKIVRTEIGVLLRL-SHPNII 111 Query: 96 TLADIVKDPVSRTPALVFEHVNNTD-FKQLYQT--LTDYDIRFYMYEILKALDYCHSMGI 152 L +I + P + LV E V + F ++ + ++ D + +IL+A+ Y H GI Sbjct: 112 KLKEIFETPTEIS--LVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGI 169 Query: 153 MHRDVKPHNVM--IDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYD 210 +HRD+KP N++ L++ D+GL++ + + PE+L Y Sbjct: 170 VHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCA-YG 228 Query: 211 YSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFN 270 +DMWS+G + ++ EPF+ + DQ + ++L E Y +I + Sbjct: 229 PEVDMWSVGIITYILLCGFEPFY--DERGDQFM-FRRILNCE--YYFISPW--------- 274 Query: 271 DILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323 W+ VS A D + KL+ D + RLT +A++HP+ Sbjct: 275 ----------WDE---------VSLNAKDLVRKLIVLDPKKRLTTFQALQHPW 308 >3H4J-B nrPDB Length = 336 Score = 81.6 bits (200), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 56/202 (27%), Positives = 104/202 (51%), Gaps = 12/202 (5%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKIL-KPVKKK-----KIKREIKILENLRGGP 92 Y + LG G + +V A + +KV +K + + + KK +++REI L+ LR P Sbjct: 11 YIIRETLGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREISYLKLLRH-P 69 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT--LTDYDIRFYMYEILKALDYCHSM 150 +II L D++ P +V E+ F + + +T+ + R + +I+ A++YCH Sbjct: 70 HIIKLYDVITTPTD--IVMVIEYAGGELFDYIVEKKRMTEDEGRRFFQQIICAIEYCHRH 127 Query: 151 GIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYD 210 I+HRD+KP N+++D ++ +++ D+GL+ G S + PE++ Sbjct: 128 KIVHRDLKPENLLLD-DNLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVINGKLYAG 186 Query: 211 YSLDMWSLGCMLASMIFRKEPF 232 +D+WS G +L M+ + PF Sbjct: 187 PEVDVWSCGIVLYVMLVGRLPF 208 >1PHK-A nrPDB Length = 298 Score = 80.9 bits (198), Expect = 9e-16, Method: Compositional matrix adjust. Identities = 78/327 (23%), Positives = 138/327 (42%), Gaps = 71/327 (21%) Query: 34 GNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK------------KKKIKRE 81 G ++Y+ LGRG S V I+ ++ VKI+ ++ +E Sbjct: 14 GFYENYEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQELREATLKE 73 Query: 82 IKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTD-FKQLYQ--TLTDYDIRFYMY 138 + IL + G PNII L D + + LVF+ + + F L + TL++ + R M Sbjct: 74 VDILRKVSGHPNIIQLKDTYE--TNTFFFLVFDLMKKGELFDYLTEKVTLSEKETRKIMR 131 Query: 139 EILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFK 198 +L+ + H + I+HRD+KP N+++D + ++L D+G + PG++ + + Sbjct: 132 ALLEVICALHKLNIVHRDLKPENILLD-DDMNIKLTDFGFSCQLDPGEKLREVCGTPSYL 190 Query: 199 GPELLV-----DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTED 253 PE++ ++ Y +DMWS G ++ +++ PF+H Q++ + Sbjct: 191 APEIIECSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPFWH----RKQMLML-------- 238 Query: 254 LYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLD-------KLLR 306 R + S N SPE D+ D + L Sbjct: 239 -----------------------------RMIMSGNYQFGSPEWDDYSDTVKDLVSRFLV 269 Query: 307 YDHQSRLTAREAMEHPYFYTVVKDQAR 333 Q R TA EA+ HP+F V ++ R Sbjct: 270 VQPQKRYTAEEALAHPFFQQYVVEEVR 296 >5IG1-A nrPDB Length = 344 Score = 80.5 bits (197), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 58/199 (29%), Positives = 101/199 (50%), Gaps = 14/199 (7%) Query: 45 LGRGKYSEVFEAINITNNEKVVVKI-----LKPVKKKKIKREIKILENLRGGPNIITLAD 99 +G+G +S V +N E VK+ L+ + KIKREI I +L+ +I+++ Sbjct: 25 IGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRSSEINKIKREIGICSSLQH-EHIVSMRR 83 Query: 100 IVKDPVSRTPALVFEHVNNTDFKQLYQTLTDY---DIRFYMYEILKALDYCHSMGIMHRD 156 +D LVFE+V+ + T Y D M++IL AL +CHS I+HRD Sbjct: 84 AFRDESHFY--LVFEYVSGGELFDEIVTRKFYNEKDASACMHQILSALQHCHSKNIIHRD 141 Query: 157 VKPHNVMIDHE--HRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLD 214 +KP N+++ + + +++ D+GLA G Y + + PE++ YD ++D Sbjct: 142 LKPENLLLASKDPNAPVKITDFGLAVIMEQGPTYFGFAGTPGYLSPEVIRRVP-YDTAVD 200 Query: 215 MWSLGCMLASMIFRKEPFF 233 +W+ G +L ++ PF+ Sbjct: 201 VWACGVILYILLVGYPPFW 219 >4I6B-A nrPDB Length = 308 Score = 80.5 bits (197), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 54/213 (25%), Positives = 109/213 (51%), Gaps = 15/213 (7%) Query: 30 VVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL------KPVKKKKIKREIK 83 +V+ Y + LG+G +++ +E ++TNN+ KI+ KP +++KI +EI+ Sbjct: 21 IVDPTTGKRYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKIDKEIE 80 Query: 84 ILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEI 140 L + +++ +D ++ E+ + + + LT+ ++R+Y+ +I Sbjct: 81 -LHRILHHKHVVQFYHYFED--KENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQI 137 Query: 141 LKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASR-YFKG 199 + L Y H I+HRD+K N I+ E +L++ D+GLA P + + + Sbjct: 138 VSGLKYLHEQEILHRDLKLGNFFIN-ESMELKVGDFGLAARLEPLEHRRRTICGTPNYLS 196 Query: 200 PELLVDYQMYDYSLDMWSLGCMLASMIFRKEPF 232 PE+L + Q + D+W+LGC++ +M+ + PF Sbjct: 197 PEVL-NKQGHGAESDIWALGCVMYTMLLGRPPF 228 >5TUR-A nrPDB Length = 404 Score = 80.5 bits (197), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 55/213 (25%), Positives = 101/213 (47%), Gaps = 17/213 (7%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK---------KKKIKREIKILE 86 + YQ+ LG G + V+ I +++N V +K ++ + ++ E+ +L+ Sbjct: 126 ESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLK 185 Query: 87 NLRGG-PNIITLADIVKDPVSRTPALVFEHVNNT----DFKQLYQTLTDYDIRFYMYEIL 141 + G +I L D + P S L+ E DF L + R + +++L Sbjct: 186 KVSSGFSGVIRLLDWFERPDSFV--LILERPEPVQDLFDFITERGALQEELARSFFWQVL 243 Query: 142 KALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPE 201 +A+ +CH+ G++HRD+K N++ID +L+LID+G Y +R + PE Sbjct: 244 EAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK-DTVYTDFDGTRVYSPPE 302 Query: 202 LLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFH 234 + ++ + S +WSLG +L M+ PF H Sbjct: 303 WIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEH 335 >4REW-A nrPDB Length = 540 Score = 80.5 bits (197), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 61/207 (29%), Positives = 98/207 (47%), Gaps = 13/207 (6%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK------KIKREIKILENLRGGP 92 Y L LG G + +V + KV VKIL K + KI+REI+ L+ R P Sbjct: 8 YILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRH-P 66 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNT---DFKQLYQTLTDYDIRFYMYEILKALDYCHS 149 +II L ++ P +V E+V+ D+ L + + R +IL +DYCH Sbjct: 67 HIIKLYQVISTP--SDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHR 124 Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMY 209 ++HRD+KP NV++D H ++ D+GL+ G+ S + PE++ Sbjct: 125 HMVVHRDLKPENVLLD-AHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYA 183 Query: 210 DYSLDMWSLGCMLASMIFRKEPFFHGH 236 +D+WS G +L +++ PF H Sbjct: 184 GPEVDIWSSGVILYALLCGTLPFDDDH 210 >3A8W-A nrPDB Length = 345 Score = 80.5 bits (197), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 63/219 (28%), Positives = 106/219 (48%), Gaps = 22/219 (10%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKI---------KREIKILENL 88 D+ L+R +GRG Y++V + + +++ +K VKK+ + + E + E Sbjct: 10 DFDLLRVIGRGSYAKVL-LVRLKKTDRIYA--MKVVKKELVNDDEDIDWVQTEKHVFEQA 66 Query: 89 RGGPNIITLADIVKDPVSRTPALVFEHVNNTDFK---QLYQTLTDYDIRFYMYEILKALD 145 P ++ L + V E+VN D Q + L + RFY EI AL+ Sbjct: 67 SNHPFLVGLHSCFQ--TESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALN 124 Query: 146 YCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLV 204 Y H GI++RD+K NV++D E ++L D+G+ E PG + + + PE+L Sbjct: 125 YLHERGIIYRDLKLDNVLLDSEGH-IKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILR 183 Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPF--FHGHDNYDQ 241 + Y +S+D W+LG ++ M+ + PF DN DQ Sbjct: 184 G-EDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQ 221 >5UUU-A nrPDB Length = 547 Score = 80.1 bits (196), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 68/275 (24%), Positives = 126/275 (45%), Gaps = 26/275 (9%) Query: 25 DYESHVVEWGN--------QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK 76 D + +W N +D+ + R +GRG + EV+ + +K L K+ Sbjct: 178 DKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDK-KRI 236 Query: 77 KIKREIKILENLRGGPNIITLAD----IVKDPVSRTP---ALVFEHVNNTDFK---QLYQ 126 K+K+ + N R ++++ D + TP + + + +N D + Sbjct: 237 KMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHG 296 Query: 127 TLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ 186 ++ D+RFY EI+ L++ H+ +++RD+KP N+++D EH +R+ D GLA + + Sbjct: 297 VFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLD-EHGHVRISDLGLACDFSKKK 355 Query: 187 EYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFF-HGHDNYDQLVRI 245 + V + + PE+L YD S D +SLGCML ++ PF H + ++ R+ Sbjct: 356 PH-ASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRM 414 Query: 246 AKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKR 280 + E D ++ EL +L R +R Sbjct: 415 TLTMAVE----LPDSFSPELRSLLEGLLQRDVNRR 445 >2WQN-A nrPDB Length = 310 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 60/222 (27%), Positives = 109/222 (49%), Gaps = 21/222 (9%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVK------ILKPVKKKKIKREIKILENLRGG 91 ++++ +K+GRG++SEV+ A + + V +K ++ + +EI +L+ L Sbjct: 33 NFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQL-NH 91 Query: 92 PNIITL-ADIVKDPVSRTPALVFEHVNNTD-------FKQLYQTLTDYDIRFYMYEILKA 143 PN+I A ++D +V E + D FK+ + + + + Y ++ A Sbjct: 92 PNVIKYYASFIED---NELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSA 148 Query: 144 LDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHP-GQEYNVRVASRYFKGPEL 202 L++ HS +MHRD+KP NV I ++L D GL F+ + V + Y+ PE Sbjct: 149 LEHMHSRRVMHRDIKPANVFITATG-VVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPER 207 Query: 203 LVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVR 244 + + Y++ D+WSLGC+L M + PF+ N L + Sbjct: 208 IHE-NGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCK 248 >1NY3-A nrPDB Length = 400 Score = 79.3 bits (194), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 59/210 (28%), Positives = 104/210 (49%), Gaps = 13/210 (6%) Query: 37 DDYQLVRK-LGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNII 95 DDY++ + LG G +V + N EK +K+L+ K + RE+++ P+I+ Sbjct: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKAR--REVELHWRASQCPHIV 118 Query: 96 TLADIVKDPVSRTPAL--VFEHVNNTD-FKQLY----QTLTDYDIRFYMYEILKALDYCH 148 + D+ ++ + L V E ++ + F ++ Q T+ + M I +A+ Y H Sbjct: 119 RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 178 Query: 149 SMGIMHRDVKPHNVMIDHE--HRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDY 206 S+ I HRDVKP N++ + + L+L D+G A+ + Y+ PE+L Sbjct: 179 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVL-GP 237 Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGH 236 + YD S DMWSLG ++ ++ PF+ H Sbjct: 238 EKYDKSCDMWSLGVIMYILLCGYPPFYSNH 267 >4CQG-A nrPDB Length = 331 Score = 79.3 bits (194), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 70/294 (23%), Positives = 131/294 (44%), Gaps = 51/294 (17%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP----VKKKKIKREIKILENLRGGPNI 94 Y+L +G G +++V A ++ E V +KI+ ++K EI L++LR +I Sbjct: 11 YELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGSDLPRVKTEIDALKSLRH-QHI 69 Query: 95 ITLADIVKDPVSRTPALVFEHVNNT---DFKQLYQTLTDYDIRFYMYEILKALDYCHSMG 151 L +++ +V E+ D+ L++ + R +IL A+ Y HS G Sbjct: 70 CQLYHVLE--TKNKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQILSAVAYVHSQG 127 Query: 152 IMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVR--VASRYFKGPELLVDYQMY 209 HRD+KP N++ D H KL+LID+GL ++Y+++ S + PEL+ Sbjct: 128 YAHRDLKPENLLFDENH-KLKLIDFGLCAKPKGNKDYHLQECCGSLAYAAPELIQGKSYL 186 Query: 210 DYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRF 269 D+WS+G +L ++ PF D+ + + K++ Sbjct: 187 GSEADVWSMGILLYVLMCGFLPF----DDDNVMALYKKIMR------------------- 223 Query: 270 NDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323 G++ +W +SP ++ L ++L+ D + R++ R + HP+ Sbjct: 224 ----GKYEVPKW-----------LSPSSILLLQQMLQVDPKKRISMRNLLNHPW 262 >2OZA-A nrPDB Length = 356 Score = 79.3 bits (194), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 59/210 (28%), Positives = 104/210 (49%), Gaps = 13/210 (6%) Query: 37 DDYQLVRK-LGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNII 95 DDY++ + LG G +V + N EK +K+L+ K + RE+++ P+I+ Sbjct: 17 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKAR--REVELHWRASQCPHIV 74 Query: 96 TLADIVKDPVSRTPAL--VFEHVNNTD-FKQLY----QTLTDYDIRFYMYEILKALDYCH 148 + D+ ++ + L V E ++ + F ++ Q T+ + M I +A+ Y H Sbjct: 75 RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 134 Query: 149 SMGIMHRDVKPHNVMIDHE--HRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDY 206 S+ I HRDVKP N++ + + L+L D+G A+ + Y+ PE+L Sbjct: 135 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVL-GP 193 Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGH 236 + YD S DMWSLG ++ ++ PF+ H Sbjct: 194 EKYDKSCDMWSLGVIMYILLCGYPPFYSNH 223 >4B6L-A nrPDB Length = 281 Score = 79.3 bits (194), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 54/200 (27%), Positives = 105/200 (52%), Gaps = 15/200 (7%) Query: 43 RKLGRGKYSEVFEAINITNNEKVVVKIL------KPVKKKKIKREIKILENLRGGPNIIT 96 R LG+G ++ +EA + VK++ KP +++KI EI++ +L+ +I+ Sbjct: 15 RLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHR-HIVR 73 Query: 97 LADIVKDPVSRTPALVFEHVNNTDFKQLYQ---TLTDYDIRFYMYEILKALDYCHSMGIM 153 + +D + + E + +++ TL + ++R+Y+ +IL L Y H GI+ Sbjct: 74 FSHHFED--ADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGIL 131 Query: 154 HRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVA-SRYFKGPELLVDYQMYDYS 212 HRD+K N I E+ +L++ D+GLA P ++ + + + PE+L+ Q + Sbjct: 132 HRDLKLGNFFIT-ENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLR-QGHGPE 189 Query: 213 LDMWSLGCMLASMIFRKEPF 232 D+WSLGC++ +++ PF Sbjct: 190 ADVWSLGCVMYTLLCGSPPF 209 >3BGP-A nrPDB Length = 333 Score = 79.3 bits (194), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 55/213 (25%), Positives = 101/213 (47%), Gaps = 17/213 (7%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK---------KKKIKREIKILE 86 + YQ+ LG G + V+ I +++N V +K ++ + ++ E+ +L+ Sbjct: 55 ESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLK 114 Query: 87 NLRGG-PNIITLADIVKDPVSRTPALVFEHVNNT----DFKQLYQTLTDYDIRFYMYEIL 141 + G +I L D + P S L+ E DF L + R + +++L Sbjct: 115 KVSSGFSGVIRLLDWFERPDSFV--LILERPEPVQDLFDFITERGALQEELARSFFWQVL 172 Query: 142 KALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPE 201 +A+ +CH+ G++HRD+K N++ID +L+LID+G Y +R + PE Sbjct: 173 EAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK-DTVYTDFDGTRVYSPPE 231 Query: 202 LLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFH 234 + ++ + S +WSLG +L M+ PF H Sbjct: 232 WIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEH 264 >3PVW-A nrPDB Length = 695 Score = 79.3 bits (194), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 68/275 (24%), Positives = 126/275 (45%), Gaps = 26/275 (9%) Query: 25 DYESHVVEWGN--------QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK 76 D + +W N +D+ + R +GRG + EV+ + +K L K+ Sbjct: 169 DKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDK-KRI 227 Query: 77 KIKREIKILENLRGGPNIITLAD----IVKDPVSRTP---ALVFEHVNNTDFK---QLYQ 126 K+K+ + N R ++++ D + TP + + + +N D + Sbjct: 228 KMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHG 287 Query: 127 TLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ 186 ++ D+RFY EI+ L++ H+ +++RD+KP N+++D EH +R+ D GLA + + Sbjct: 288 VFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLD-EHGHVRISDLGLACDFSKKK 346 Query: 187 EYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFF-HGHDNYDQLVRI 245 + V + + PE+L YD S D +SLGCML ++ PF H + ++ R+ Sbjct: 347 PH-ASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRM 405 Query: 246 AKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKR 280 + E D ++ EL +L R +R Sbjct: 406 TLTMAVE----LPDSFSPELRSLLEGLLQRDVNRR 436 >4RC3-A nrPDB Length = 289 Score = 79.0 bits (193), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 55/213 (25%), Positives = 101/213 (47%), Gaps = 17/213 (7%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK---------KKKIKREIKILE 86 + YQ+ LG G + V+ I +++N V +K ++ + ++ E+ +L+ Sbjct: 11 ESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLK 70 Query: 87 NLRGG-PNIITLADIVKDPVSRTPALVFEHVNNT----DFKQLYQTLTDYDIRFYMYEIL 141 + G +I L D + P S L+ E DF L + R + +++L Sbjct: 71 KVSSGFSGVIRLLDWFERPDSFV--LILERPEPVQDLFDFITERGALQEELARSFFWQVL 128 Query: 142 KALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPE 201 +A+ +CH+ G++HRD+K N++ID +L+LID+G Y +R + PE Sbjct: 129 EAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK-DTVYTDFDGTRVYSPPE 187 Query: 202 LLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFH 234 + ++ + S +WSLG +L M+ PF H Sbjct: 188 WIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEH 220 >2V7O-A nrPDB Length = 336 Score = 79.0 bits (193), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 75/300 (25%), Positives = 141/300 (47%), Gaps = 53/300 (17%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK-----KKKIKREIKILENLRGG 91 DDYQL +LG+G +S V + T ++ KI+ K +K++RE +I L+ Sbjct: 31 DDYQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSARDHQKLEREARICRLLKH- 89 Query: 92 PNIITLADIVKDPVSRTPALVFEHVNNTD-FKQLY--QTLTDYDIRFYMYEILKALDYCH 148 PNI+ L D + + LVF+ V + F+ + + ++ D +++IL+++++ H Sbjct: 90 PNIVRLHDSISEEGFHY--LVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIH 147 Query: 149 SMGIMHRDVKPHNVMIDHEHR--KLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLVD 205 I+HRD+KP N+++ + + ++L D+GLA E Q + + + PE+L Sbjct: 148 QHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRK 207 Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFF--HGHDNYDQLVRIAKVLGTEDLYDYIDKYNI 263 Y +D+W+ G +L ++ PF+ H Y Q+ A YD+ Sbjct: 208 -DPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGA--------YDF------ 252 Query: 264 ELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323 W+ V+PEA + ++++L + R+TA +A++HP+ Sbjct: 253 -------------PSPEWDT---------VTPEAKNLINQMLTINPAKRITADQALKHPW 290 >4CFH-A nrPDB Length = 493 Score = 78.6 bits (192), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 61/207 (29%), Positives = 98/207 (47%), Gaps = 13/207 (6%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK------KIKREIKILENLRGGP 92 Y L LG G + +V + KV VKIL K + KI+REI+ L+ R P Sbjct: 35 YILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRH-P 93 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNT---DFKQLYQTLTDYDIRFYMYEILKALDYCHS 149 +II L ++ P +V E+V+ D+ L + + R +IL +DYCH Sbjct: 94 HIIKLYQVISTP--SDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHR 151 Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMY 209 ++HRD+KP NV++D H ++ D+GL+ G+ S + PE++ Sbjct: 152 HMVVHRDLKPENVLLD-AHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYA 210 Query: 210 DYSLDMWSLGCMLASMIFRKEPFFHGH 236 +D+WS G +L +++ PF H Sbjct: 211 GPEVDIWSSGVILYALLCGTLPFDDDH 237 >3KA0-A nrPDB Length = 320 Score = 78.6 bits (192), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 59/210 (28%), Positives = 104/210 (49%), Gaps = 13/210 (6%) Query: 37 DDYQLVRK-LGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNII 95 DDY++ + LG G +V + N EK +K+L+ K + RE+++ P+I+ Sbjct: 15 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKAR--REVELHWRASQCPHIV 72 Query: 96 TLADIVKDPVSRTPAL--VFEHVNNTD-FKQLY----QTLTDYDIRFYMYEILKALDYCH 148 + D+ ++ + L V E ++ + F ++ Q T+ + M I +A+ Y H Sbjct: 73 RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 132 Query: 149 SMGIMHRDVKPHNVMIDHE--HRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDY 206 S+ I HRDVKP N++ + + L+L D+G A+ + Y+ PE+L Sbjct: 133 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTEPCYTPYYVAPEVL-GP 191 Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGH 236 + YD S DMWSLG ++ ++ PF+ H Sbjct: 192 EKYDKSCDMWSLGVIMYILLCGYPPFYSNH 221 >5YV8-A nrPDB Length = 298 Score = 78.6 bits (192), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 62/233 (26%), Positives = 109/233 (46%), Gaps = 40/233 (17%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKR---------------- 80 + Y L ++G+G Y V A N +N +K+L KKK I++ Sbjct: 13 NQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLS--KKKLIRQAGFPRRPPPRGTRPAP 70 Query: 81 ---------------EIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQL- 124 EI IL+ L PN++ L +++ DP +VFE VN ++ Sbjct: 71 GGCIQPRGPIEQVYQEIAILKKLDH-PNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVP 129 Query: 125 -YQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFY 182 + L++ RFY +++K ++Y H I+HRD+KP N+++ E +++ D+G++ EF Sbjct: 130 TLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVG-EDGHIKIADFGVSNEFK 188 Query: 183 HPGQEYNVRVASRYFKGPELLVDYQ--MYDYSLDMWSLGCMLASMIFRKEPFF 233 + V + F PE L + + +LD+W++G L +F + PF Sbjct: 189 GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFM 241 >5D9K-A nrPDB Length = 330 Score = 78.6 bits (192), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 60/229 (26%), Positives = 115/229 (50%), Gaps = 18/229 (7%) Query: 32 EWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLR-- 89 E + ++L++ LG+G + +VF I+ ++ + +K +KK +K ++ + Sbjct: 25 EKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERD 84 Query: 90 -----GGPNIITLADIVKDPVSRTPALVFEHVNNTD-FKQLYQTL--TDYDIRFYMYEIL 141 P I+ L + L+ + + D F +L + + T+ D++FY+ E+ Sbjct: 85 ILVEVNHPFIVKLHYAFQ--TEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELA 142 Query: 142 KALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE--FYHPGQEYNVRVASRYFKG 199 ALD+ HS+GI++RD+KP N+++D E ++L D+GL++ H + Y+ Y Sbjct: 143 LALDHLHSLGIIYRDLKPENILLDEEGH-IKLTDFGLSKESIDHEKKAYSFCGTVEYM-A 200 Query: 200 PELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKV 248 PE +V+ + + S D WS G ++ M+ P F G D + + I K Sbjct: 201 PE-VVNRRGHTQSADWWSFGVLMFEMLTGTLP-FQGKDRKETMTMILKA 247 >2YCR-A nrPDB Length = 323 Score = 78.6 bits (192), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 75/307 (24%), Positives = 129/307 (42%), Gaps = 55/307 (17%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK-----------KKKIKREIKI 84 +D+Y + + LG G EV A +KV +KI+ K ++ EI+I Sbjct: 9 RDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEI 68 Query: 85 LENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTD-FKQLY--QTLTDYDIRFYMYEIL 141 L+ L P II + + + +V E + + F ++ + L + + Y Y++L Sbjct: 69 LKKL-NHPCIIKIKNFFD---AEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQML 124 Query: 142 KALDYCHSMGIMHRDVKPHNVMIDHEHRK--LRLIDWGLAEFYHPGQEYNVRVASRYFKG 199 A+ Y H GI+HRD+KP NV++ + +++ D+G ++ + + Sbjct: 125 LAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLA 184 Query: 200 PELLVDYQM--YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDY 257 PE+LV Y+ ++D WSLG +L + PF +I T Y++ Sbjct: 185 PEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQI-----TSGKYNF 239 Query: 258 IDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTARE 317 I + E VS +ALD + KLL D ++R T E Sbjct: 240 IPEVWAE----------------------------VSEKALDLVKKLLVVDPKARFTTEE 271 Query: 318 AMEHPYF 324 A+ HP+ Sbjct: 272 ALRHPWL 278 >4JXF-A nrPDB Length = 266 Score = 78.6 bits (192), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 69/299 (23%), Positives = 136/299 (45%), Gaps = 54/299 (18%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL------KPVKKKKIKREIKILENLRG 90 +D+++ LG+G ++ V+ A +I +V +K++ K ++++ E+KI L+ Sbjct: 7 EDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKH 66 Query: 91 GPNIITLADIVKDPVSRTPALVFEHVNNTD----FKQLYQTLTDYDIRFYMYEILKALDY 146 P+I+ L + +D S LV E +N + K + ++ + R +M++I+ + Y Sbjct: 67 -PSILELYNYFED--SNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLY 123 Query: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLVD 205 HS GI+HRD+ N+++ + +++ D+GLA + P +++ + + PE + Sbjct: 124 LHSHGILHRDLTLSNLLLT-RNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPE-IAT 181 Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIEL 265 + D+WSLGCM +++ + PF + D + L L DY Sbjct: 182 RSAHGLESDVWSLGCMFYTLLIGRPPF-----DTDT---VKNTLNKVVLADY-------- 225 Query: 266 DPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 E +S EA D + +LLR + RL+ ++HP+ Sbjct: 226 ----------------------EMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFM 262 >4D28-A nrPDB Length = 446 Score = 78.2 bits (191), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 64/206 (31%), Positives = 110/206 (53%), Gaps = 18/206 (8%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKI------LKPVKKKKIKREIKILENLRGGP 92 Y++ R +G G +++V A N + V +KI LK +IKREI I++ +R P Sbjct: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH-P 69 Query: 93 NIITLADIVKDPVSRTPA-LVFEHVNNTD-FKQLYQT--LTDYDIRFYMYEILKALDYCH 148 NI+ L +++ S++ +V E V + F ++ L + + R Y +++ A+ +CH Sbjct: 70 NIVRLYEVL---ASKSKIYIVLEFVTGGELFDRIVHKGRLKEDESRKYFQQLVDAVAHCH 126 Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE-YNVRVASRYFKGPELLVDYQ 207 S G+ HRD+KP N+++D + L++ D+GL+ G E N + + PE+L Q Sbjct: 127 SKGVYHRDLKPENLLLD-TNGNLKVSDFGLSALPQEGVELLNDTCGTPNYVAPEVL-SGQ 184 Query: 208 MYDYS-LDMWSLGCMLASMIFRKEPF 232 YD S D+WS G +L ++ PF Sbjct: 185 GYDGSAADIWSCGVILFVILAGYLPF 210 >2Z7Q-A nrPDB Length = 321 Score = 78.2 bits (191), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 64/239 (26%), Positives = 121/239 (50%), Gaps = 26/239 (10%) Query: 28 SHVVEWGNQ----DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIK 83 +H V+ G++ ++L++ LG+G + +VF +T + + +K +KK +K Sbjct: 15 THHVKAGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLK---- 70 Query: 84 ILENLRGGPNIITLADIVKDPVSR---------TPALVFEHVNNTD-FKQLYQTL--TDY 131 + + +R LAD+ V + L+ + + D F +L + + T+ Sbjct: 71 VRDRVRTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEE 130 Query: 132 DIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE--FYHPGQEYN 189 D++FY+ E+ LD+ HS+GI++RD+KP N+++D E ++L D+GL++ H + Y+ Sbjct: 131 DVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGH-IKLTDFGLSKEAIDHEKKAYS 189 Query: 190 VRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKV 248 Y PE +V+ Q + +S D WS G ++ M+ P F G D + + I K Sbjct: 190 FCGTVEYM-APE-VVNRQGHSHSADWWSYGVLMFEMLTGSLP-FQGKDRKETMTLILKA 245 >5JZN-A nrPDB Length = 280 Score = 78.2 bits (191), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 75/296 (25%), Positives = 132/296 (44%), Gaps = 50/296 (16%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK----IKREIKILENLRGGPNI 94 Y++ R +G G ++ V E + + + +KI+K K + I+ E+ IL ++ PNI Sbjct: 21 YKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHMIQNEVSILRRVKH-PNI 79 Query: 95 ITLADIVKDPVSRTPALVFEHVNNTD-FKQLYQT--LTDYDIRFYMYEILKALDYCHSMG 151 + L + + P LV E V D F + T T+ D +Y + A+ Y HS+ Sbjct: 80 VLLIEEMDVPTELY--LVMELVKGGDLFDAITSTNKYTERDASGMLYNLASAIKYLHSLN 137 Query: 152 IMHRDVKPHNVMIDHEH----RKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQ 207 I+HRD+KP N+++ +EH + L+L D+GLA G Y V + + PE++ + Sbjct: 138 IVHRDIKPENLLV-YEHQDGSKSLKLGDFGLATIVD-GPLYTV-CGTPTYVAPEIIAETG 194 Query: 208 MYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDP 267 Y +D+W+ G + ++ PF D+ E L+D I ++ Sbjct: 195 -YGLKVDIWAAGVITYILLCGFPPFRGSGDD------------QEVLFDQILMGQVDFPS 241 Query: 268 RFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323 + W+ VS A + + +L D R +A + +EHP+ Sbjct: 242 PY-----------WDN---------VSDSAKELITMMLLVDVDQRFSAVQVLEHPW 277 >6FD3-A nrPDB Length = 300 Score = 77.8 bits (190), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 70/294 (23%), Positives = 131/294 (44%), Gaps = 50/294 (17%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVK---ILKPVKKKKIKREIKILENLRGGPNII 95 Y K+G+G V+ A++I ++V +K + + KK+ I EI ++ + PNI+ Sbjct: 24 YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKN-PNIV 82 Query: 96 TLAD--IVKDPVSRTPALVFEHVNNTDFKQLYQ--TLTDYDIRFYMYEILKALDYCHSMG 151 D +V D + +V E++ + + + I E L+ALD+ HS Sbjct: 83 NYLDSYLVGDEL----WVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQ 138 Query: 152 IMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ-EYNVRVASRYFKGPELLVDYQMYD 210 ++HRD+K N+++ + ++L D+G P Q + + V + Y+ PE +V + Y Sbjct: 139 VIHRDIKSDNILLGMDG-SVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPE-VVTRKAYG 196 Query: 211 YSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFN 270 +D+WSLG M M+ + P+ ++N + + + GT +L Sbjct: 197 PKVDIWSLGIMAIEMVEGEPPYL--NENPLRALYLIATNGTPEL---------------- 238 Query: 271 DILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 +N +S DFL++ L D R +A+E ++HP+ Sbjct: 239 -----------------QNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFL 275 >6FYV-A nrPDB Length = 337 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 79/335 (23%), Positives = 152/335 (45%), Gaps = 67/335 (20%) Query: 39 YQLVRKLGRGKYSEVFEAINI-TNNEKVVVKILKPVK--KKKIKREIKILENLRGG-PNI 94 Y++V LG G + +V E I+ + V VKI+K V ++ + EI++LE+L PN Sbjct: 16 YEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPN- 74 Query: 95 ITLADIVKDPVSRTPALV--FEHVNNTDFKQLYQTLTDYD--------------IRFYMY 138 V R ++ F+H + L+ YD IR Y Sbjct: 75 ---------SVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAY 125 Query: 139 EILKALDYCHSMGIMHRDVKPHNVM-------------IDHEHRKL-----RLIDWGLAE 180 +I +++++ H + H D+KP N++ + + R L +++D+G A Sbjct: 126 QICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSAT 185 Query: 181 FYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYD 240 + + ++ V++R+++ PE+++ + D+WS+GC+L + F HD+ + Sbjct: 186 Y--DDEHHSTLVSTRHYRAPEVILALG-WSQPCDVWSIGCILIEY-YLGFTVFQTHDSKE 241 Query: 241 QLVRIAKVLG--TEDLYDYIDK----YNIELDPRFNDILGRHSRKRWE-----RFVHSEN 289 L + ++LG + + K ++ +LD + GR+ R+R + H E Sbjct: 242 HLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEE 301 Query: 290 QHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 + D + ++L YD R+T EA++HP+F Sbjct: 302 H----EKLFDLVRRMLEYDPTQRITLDEALQHPFF 332 >3UC3-A nrPDB Length = 361 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 71/300 (23%), Positives = 128/300 (42%), Gaps = 49/300 (16%) Query: 35 NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK--PVKKKKIKREIKILENLRGGP 92 + D Y V+ +G G + + E V VK ++ + ++REI +LR P Sbjct: 18 DSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGAAIDENVQREIINHRSLRH-P 76 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDY------DIRFYMYEILKALDY 146 NI+ +++ P A++ E+ + +LY+ + + + RF+ ++L + Y Sbjct: 77 NIVRFKEVILTPTHL--AIIMEYASG---GELYERICNAGRFSEDEARFFFQQLLSGVSY 131 Query: 147 CHSMGIMHRDVKPHNVMIDHEHR-KLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVD 205 CHSM I HRD+K N ++D +L++ D+G ++ + V + + PE+L+ Sbjct: 132 CHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL- 190 Query: 206 YQMYDYSL-DMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIE 264 Q YD + D+WS G L M+ PF + D I ++L KY+I Sbjct: 191 RQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSV--------KYSIP 242 Query: 265 LDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 D R +SPE + ++ D +R++ E H +F Sbjct: 243 DDIR------------------------ISPECCHLISRIFVADPATRISIPEIKTHSWF 278 >2BRG-A nrPDB Length = 297 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 59/218 (27%), Positives = 107/218 (49%), Gaps = 20/218 (9%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNI-- 94 +D+ LV+ LG G Y EV A+N E V VKI+ +KR + EN++ I Sbjct: 7 EDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVD------MKRAVDCPENIKKEICINK 60 Query: 95 -ITLADIVKDPVSRTPA----LVFEHVNNTDFKQLYQ---TLTDYDIRFYMYEILKALDY 146 + ++VK R L E+ + + + + + D + + ++++ + Y Sbjct: 61 MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVY 120 Query: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE-FYHPGQE--YNVRVASRYFKGPELL 203 H +GI HRD+KP N+++D E L++ D+GLA F + +E N + + PELL Sbjct: 121 LHGIGITHRDIKPENLLLD-ERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELL 179 Query: 204 VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQ 241 + + +D+WS G +L +M+ + P+ D+ + Sbjct: 180 KRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQE 217 >4RED-A nrPDB Length = 351 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 60/207 (28%), Positives = 97/207 (46%), Gaps = 13/207 (6%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK------KIKREIKILENLRGGP 92 Y L LG G + +V + V VKIL K + KI+REI+ L+ R P Sbjct: 16 YILGDTLGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLDVVGKIRREIQNLKLFRH-P 74 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNT---DFKQLYQTLTDYDIRFYMYEILKALDYCHS 149 +II L ++ P +V E+V+ D+ L + + R +IL +DYCH Sbjct: 75 HIIKLYQVISTP--SDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHR 132 Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMY 209 ++HRD+KP NV++D H ++ D+GL+ G+ S + PE++ Sbjct: 133 HMVVHRDLKPENVLLD-AHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYA 191 Query: 210 DYSLDMWSLGCMLASMIFRKEPFFHGH 236 +D+WS G +L +++ PF H Sbjct: 192 GPEVDIWSSGVILYALLCGTLPFDDDH 218 >3I6U-A nrPDB Length = 419 Score = 75.9 bits (185), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 74/307 (24%), Positives = 129/307 (42%), Gaps = 55/307 (17%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK-----------KKKIKREIKI 84 +D+Y + + LG G EV A +KV ++I+ K ++ EI+I Sbjct: 134 RDEYIMSKTLGSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSAREADPALNVETEIEI 193 Query: 85 LENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTD-FKQLY--QTLTDYDIRFYMYEIL 141 L+ L P II + + + +V E + + F ++ + L + + Y Y++L Sbjct: 194 LKKL-NHPCIIKIKNFFD---AEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQML 249 Query: 142 KALDYCHSMGIMHRDVKPHNVMIDHEHRK--LRLIDWGLAEFYHPGQEYNVRVASRYFKG 199 A+ Y H GI+HRD+KP NV++ + +++ D+G ++ + + Sbjct: 250 LAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLA 309 Query: 200 PELLVDYQM--YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDY 257 PE+LV Y+ ++D WSLG +L + PF +I T Y++ Sbjct: 310 PEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQI-----TSGKYNF 364 Query: 258 IDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTARE 317 I + E VS +ALD + KLL D ++R T E Sbjct: 365 IPEVWAE----------------------------VSEKALDLVKKLLVVDPKARFTTEE 396 Query: 318 AMEHPYF 324 A+ HP+ Sbjct: 397 ALRHPWL 403 >2JD5-A nrPDB Length = 373 Score = 75.9 bits (185), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 99/355 (27%), Positives = 164/355 (46%), Gaps = 65/355 (18%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILK--PVKKKKIKREIKIL----------E 86 Y LVRKLG G +S V+ A ++ NN V +KI++ V + + EIK+L E Sbjct: 21 YILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVRGDKVYTEAAEDEIKLLQRVNDADNTKE 80 Query: 87 NLRGGPNIITLADIV--KDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIR----FYMYEI 140 + G +I+ L D K P +VFE + + L + Y+ R Y+ +I Sbjct: 81 DSMGANHILKLLDHFNHKGPNGVHVVMVFEVLG----ENLLALIKKYEHRGIPLIYVKQI 136 Query: 141 LK----ALDYCH-SMGIMHRDVKPHNVMID-----HEHRKLRLIDWGLAEFYHPGQEYNV 190 K LDY H GI+H D+KP NV+++ ++++ D G A +Y + Y Sbjct: 137 SKQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNACWY--DEHYTN 194 Query: 191 RVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMI---FRKEPFFHGHD---NYDQLVR 244 + +R ++ PE+L+ + D+WS C++ +I F EP GH + D + + Sbjct: 195 SIQTREYRSPEVLLGAP-WGCGADIWSTACLIFELITGDFLFEP-DEGHSYTKDDDHIAQ 252 Query: 245 IAKVLGTEDLYDYIDKYNIELDPRFND--ILGRHSR-KRW-------ERFVHSENQHLVS 294 I ++LG +L Y+ + FN +L S+ K W E++ S+++ + Sbjct: 253 IIELLG--ELPSYLLRNGKYTRTFFNSRGLLRNISKLKFWPLEDVLTEKYKFSKDE---A 307 Query: 295 PEALDFLDKLLRYDHQSRLTAREAMEHPYFYTV-------VKDQARMGSSS-MPG 341 E DFL +L+ D + R A + HP+ V D+ GS S +PG Sbjct: 308 KEISDFLSPMLQLDPRKRADAGGLVNHPWLKDTLGMEEIRVPDRELYGSGSDIPG 362 >1U5R-A nrPDB Length = 348 Score = 75.9 bits (185), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 58/204 (28%), Positives = 102/204 (50%), Gaps = 18/204 (8%) Query: 42 VRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK------IKREIKILENLRGGPNII 95 +R++G G + V+ A ++ N+E V +K + K+ I +E++ L+ LR PN I Sbjct: 59 LREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRH-PNTI 117 Query: 96 TLADIVKDPVSRTPALVFEHV--NNTDFKQLYQT-LTDYDIRFYMYEILKALDYCHSMGI 152 T LV E+ + +D ++++ L + +I + L+ L Y HS + Sbjct: 118 QYRGCYLR--EHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHSHNM 175 Query: 153 MHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLV--DYQMYD 210 +HRDVK N+++ E ++L D+G A P + V + Y+ PE+++ D YD Sbjct: 176 IHRDVKAGNILLS-EPGLVKLGDFGSASIMAPANSF---VGTPYWMAPEVILAMDEGQYD 231 Query: 211 YSLDMWSLGCMLASMIFRKEPFFH 234 +D+WSLG + RK P F+ Sbjct: 232 GKVDVWSLGITCIELAERKPPLFN 255 >5J5T-A nrPDB Length = 370 Score = 75.5 bits (184), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 68/294 (23%), Positives = 139/294 (47%), Gaps = 24/294 (8%) Query: 34 GNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK---IKREIKILENLRG 90 G+Q+D++L++++G G Y +V++A N+ E +K++K + +++EI ++++ + Sbjct: 1 GSQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCK- 59 Query: 91 GPNIITL--ADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALD 145 PNI+ + + +D + + E + +Y L++ I + E L+ L Sbjct: 60 HPNIVAYFGSYLRRDKL----WICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLY 115 Query: 146 YCHSMGIMHRDVKPHNVMI-DHEHRKLRLIDWGL-AEFYHPGQEYNVRVASRYFKGPELL 203 Y HS G MHRD+K N+++ D+ H ++L D+G+ A+ + + + Y+ PE+ Sbjct: 116 YLHSKGKMHRDIKGANILLTDNGH--VKLADFGVSAQITATIAKRKAFIGTPYWMAPEVA 173 Query: 204 VDYQM--YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKY 261 + Y+ D+W++G + + P F H + L D + K+ Sbjct: 174 AVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKM-KW 232 Query: 262 NIELDPRFNDILGRHSRKR--WERFVHSE--NQHLVSPEALDFLDKLLRYDHQS 311 + L ++ +KR E+ + QHL A++ LDK+ DH + Sbjct: 233 SNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQHLTRSLAIELLDKVNNPDHST 286 >4X7Q-B nrPDB Length = 312 Score = 75.5 bits (184), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 54/213 (25%), Positives = 96/213 (45%), Gaps = 19/213 (8%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL--------KPVKKK-KIKREIKILE 86 + +Y+L LG+G + VF +T+ +V +K++ P+ E+ +L Sbjct: 30 EAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLW 89 Query: 87 NLRGG---PNIITLADIVKDPVSRTPALVFEHV----NNTDFKQLYQTLTDYDIRFYMYE 139 + G P +I L D + LV E + D+ L + R + + Sbjct: 90 KVGAGGGHPGVIRLLDWFE--TQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQ 147 Query: 140 ILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKG 199 ++ A+ +CHS G++HRD+K N++ID +LID+G H + Y +R + Sbjct: 148 VVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLH-DEPYTDFDGTRVYSP 206 Query: 200 PELLVDYQMYDYSLDMWSLGCMLASMIFRKEPF 232 PE + +Q + +WSLG +L M+ PF Sbjct: 207 PEWISRHQYHALPATVWSLGILLYDMVCGDIPF 239 >3FXW-A nrPDB Length = 336 Score = 75.1 bits (183), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 58/207 (28%), Positives = 101/207 (48%), Gaps = 14/207 (6%) Query: 37 DDYQLVRK-LGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNII 95 DDYQL ++ LG G +V E + +K +K+L K ++E+ GGP+I+ Sbjct: 28 DDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLL--YDSPKARQEVDHHWQASGGPHIV 85 Query: 96 TLADIVKDP--VSRTPALVFEHVNNTD-FKQLY----QTLTDYDIRFYMYEILKALDYCH 148 + D+ ++ R ++ E + + F ++ Q T+ + M +I A+ + H Sbjct: 86 CILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLH 145 Query: 149 SMGIMHRDVKPHNVMIDHEHRK--LRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDY 206 S I HRDVKP N++ + + L+L D+G A+ + Y+ PE+L Sbjct: 146 SHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAK-ETTQNALQTPCYTPYYVAPEVL-GP 203 Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFF 233 + YD S DMWSLG ++ ++ PF+ Sbjct: 204 EKYDKSCDMWSLGVIMYILLCGFPPFY 230 >3ZUT-A nrPDB Length = 362 Score = 75.1 bits (183), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 52/204 (25%), Positives = 103/204 (50%), Gaps = 9/204 (4%) Query: 35 NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK--KKIKREIKILENLRGGP 92 + D Y+LV+ +G G + + +NE V VK ++ +K + +KREI +LR P Sbjct: 17 DSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRH-P 75 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNTD-FKQLYQT--LTDYDIRFYMYEILKALDYCHS 149 NI+ +++ P A+V E+ + + F+++ ++ + RF+ +++ + YCH+ Sbjct: 76 NIVRFKEVILTPTHL--AIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHA 133 Query: 150 MGIMHRDVKPHNVMIDHEHR-KLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQM 208 M + HRD+K N ++D +L++ +G ++ + V + + PE+L+ + Sbjct: 134 MQVCHRDLKLENTLLDGSPAPRLKICAFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEY 193 Query: 209 YDYSLDMWSLGCMLASMIFRKEPF 232 D+WS G L M+ PF Sbjct: 194 DGKVADVWSCGVTLYVMLVGAYPF 217 >2GCD-A nrPDB Length = 309 Score = 74.7 bits (182), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 58/204 (28%), Positives = 102/204 (50%), Gaps = 18/204 (8%) Query: 42 VRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK------IKREIKILENLRGGPNII 95 +R++G G + V+ A ++ N+E V +K + K+ I +E++ L+ LR PN I Sbjct: 20 LREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRH-PNTI 78 Query: 96 TLADIVKDPVSRTPALVFEHV--NNTDFKQLYQT-LTDYDIRFYMYEILKALDYCHSMGI 152 T LV E+ + +D ++++ L + +I + L+ L Y HS + Sbjct: 79 QYRGCYLR--EHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHSHNM 136 Query: 153 MHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLV--DYQMYD 210 +HRDVK N+++ E ++L D+G A P + V + Y+ PE+++ D YD Sbjct: 137 IHRDVKAGNILLS-EPGLVKLGDFGSASIMAPANSF---VGTPYWMAPEVILAMDEGQYD 192 Query: 211 YSLDMWSLGCMLASMIFRKEPFFH 234 +D+WSLG + RK P F+ Sbjct: 193 GKVDVWSLGITCIELAERKPPLFN 216 >3LM0-A nrPDB Length = 327 Score = 74.7 bits (182), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 51/218 (23%), Positives = 112/218 (51%), Gaps = 16/218 (7%) Query: 43 RKLGRGKYSEVFEAINITNNEKVVVKILKPVKK-----KKIKREIKILENLRGGPNIITL 97 ++LGRGK++ V + I+ + ++ K LK ++ +I EI +LE + P +I L Sbjct: 35 KELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELAKSCPRVINL 94 Query: 98 ADIVKDPVSRTPALVFEHVNNTD-----FKQLYQTLTDYDIRFYMYEILKALDYCHSMGI 152 ++ ++ + L+ E+ + +L + +++ D+ + +IL+ + Y H I Sbjct: 95 HEVYEN--TSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQNNI 152 Query: 153 MHRDVKPHNVMIDHEH--RKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYD 210 +H D+KP N+++ + ++++D+G++ E + + + PE+L +Y Sbjct: 153 VHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACELREIMGTPEYLAPEIL-NYDPIT 211 Query: 211 YSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKV 248 + DMW++G ++A M+ F G DN + + I++V Sbjct: 212 TATDMWNIG-IIAYMLLTHTSPFVGEDNQETYLNISQV 248 >3HKO-A nrPDB Length = 345 Score = 74.3 bits (181), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 85/352 (24%), Positives = 142/352 (40%), Gaps = 105/352 (29%) Query: 36 QDDYQLVRKLGRGKYSEV----------FEAINITNNEKVVVKILKPVKKKKIKREIKIL 85 Q Y L +G+G Y V AI I N K+ + + P ++IK E++++ Sbjct: 25 QKKYHLKGAIGQGSYGVVRVAIENQTRAIRAIKIMNKNKI--RQINPKDVERIKTEVRLM 82 Query: 86 ENLRGGPNIITL--------------------------------------ADIVKDPVSR 107 + L PNI L D+VK + Sbjct: 83 KKLHH-PNIARLYEVYEDEQYICLVMELCHGGHLLDKLNVFIDDSTGKCAMDVVKTQICP 141 Query: 108 TPALVFEHVNNT--------DFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKP 159 P E +N + DF Q + +++ M +I AL Y H+ GI HRD+KP Sbjct: 142 CPECNEEAINGSIHGFRESLDFVQREKLISNI-----MRQIFSALHYLHNQGICHRDIKP 196 Query: 160 HNVMID-HEHRKLRLIDWGLA-EFY--HPGQEYNV--RVASRYFKGPELL-VDYQMYDYS 212 N + ++ +++L+D+GL+ EFY + G+ Y + + + YF PE+L + Y Sbjct: 197 ENFLFSTNKSFEIKLVDFGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEVLNTTNESYGPK 256 Query: 213 LDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDI 272 D WS G +L ++ P F G ++ D I++VL + ++ +P +N Sbjct: 257 CDAWSAGVLLHLLLMGAVP-FPGVNDADT---ISQVLNKKLCFE---------NPNYN-- 301 Query: 273 LGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 ++SP A D L LL + R A A++HP+ Sbjct: 302 -------------------VLSPLARDLLSNLLNRNVDERFDAMRALQHPWI 334 >2JAM-A nrPDB Length = 304 Score = 74.3 bits (181), Expect = 8e-14, Method: Compositional matrix adjust. Identities = 69/287 (24%), Positives = 127/287 (44%), Gaps = 47/287 (16%) Query: 45 LGRGKYSEVFEAINITNNEKVVVKILK---PVKKKKIKREIKILENLRGGPNIITLADIV 101 LG G +SEVF + +K +K + ++ EI +L+ ++ NI+TL DI Sbjct: 17 LGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDSSLENEIAVLKKIKH-ENIVTLEDIY 75 Query: 102 KDPVSRTPALVFEHVNNTD-FKQLYQ--TLTDYDIRFYMYEILKALDYCHSMGIMHRDVK 158 + LV + V+ + F ++ + T+ D + ++L A+ Y H GI+HRD+K Sbjct: 76 ESTTHYY--LVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHENGIVHRDLK 133 Query: 159 PHNV--MIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMW 216 P N+ + E+ K+ + D+GL++ G + + + PE+L + Y ++D W Sbjct: 134 PENLLYLTPEENSKIMITDFGLSKMEQNGI-MSTACGTPGYVAPEVLAQ-KPYSKAVDCW 191 Query: 217 SLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRH 276 S+G + ++ PF+ ++ L++ I + E + F Sbjct: 192 SIGVITYILLCGYPPFYEETES--------------KLFEKIKEGYYEFESPF------- 230 Query: 277 SRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323 W+ +S A DF+ LL D R T +A+ HP+ Sbjct: 231 ----WDD---------ISESAKDFICHLLEKDPNERYTCEKALSHPW 264 >6CKI-A nrPDB Length = 316 Score = 74.3 bits (181), Expect = 9e-14, Method: Compositional matrix adjust. Identities = 72/309 (23%), Positives = 139/309 (44%), Gaps = 42/309 (13%) Query: 36 QDDYQLVRK-LGRGKYSEVFEAINITNNEKVVVKILKPVK---KKKIKREIKILENLRGG 91 +D YQL LG G ++ V IN+ +++ VKI++ + ++ RE+++L +G Sbjct: 11 EDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQCQGH 70 Query: 92 PNIITLADIVKDPVSRTPALVFEHV-NNTDFKQLYQT--LTDYDIRFYMYEILKALDYCH 148 N++ L + + LVFE + + +++ + + + ++ ALD+ H Sbjct: 71 RNVLELIEFFE--EEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLH 128 Query: 149 SMGIMHRDVKPHNVMIDHEHR--KLRLIDWGLAEFYH--------PGQEYNVRVASRYFK 198 + GI HRD+KP N++ +H ++ +++ D+GL E S + Sbjct: 129 NKGIAHRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPELLTPCGSAEYM 188 Query: 199 GPELLVDY----QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDL 254 PE++ + +YD D+WSLG +L ++ PF G++ Sbjct: 189 APEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPF-------------VGRCGSDCG 235 Query: 255 YDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT 314 +D E P ++L ++ F + H +S A D + KLL D + RL+ Sbjct: 236 WD-----RGEACPACQNMLFESIQEGKYEFPDKDWAH-ISCAAKDLISKLLVRDAKQRLS 289 Query: 315 AREAMEHPY 323 A + ++HP+ Sbjct: 290 AAQVLQHPW 298 >3NYO-A nrPDB Length = 576 Score = 74.3 bits (181), Expect = 9e-14, Method: Compositional matrix adjust. Identities = 58/195 (29%), Positives = 85/195 (43%), Gaps = 41/195 (21%) Query: 135 FYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVAS 194 FY EI L+ H I++RD+KP N+++D +H +R+ D GLA GQ RV + Sbjct: 290 FYAAEICCGLEDLHRERIVYRDLKPENILLD-DHGHIRISDLGLAVHVPEGQTIKGRVGT 348 Query: 195 RYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDL 254 + PE+ V + Y +S D W+LGC+L MI + PF + K + E++ Sbjct: 349 VGYMAPEV-VKNERYTFSPDWWALGCLLYEMIAGQSPF----------QQRKKKIKREEV 397 Query: 255 YDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRL- 313 + + E RF SP+A +LL D RL Sbjct: 398 ERLVKEVPEEYSERF------------------------SPQARSLCSQLLCKDPAERLG 433 Query: 314 ----TAREAMEHPYF 324 +ARE EHP F Sbjct: 434 CRGGSAREVKEHPLF 448 >1VZO-A nrPDB Length = 355 Score = 73.9 bits (180), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 55/212 (25%), Positives = 110/212 (51%), Gaps = 19/212 (8%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKI----------KREIKILE 86 ++++L++ LG G Y +VF I+ ++ + +K +KK I + E ++LE Sbjct: 54 ENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLE 113 Query: 87 NLRGGPNIITLADIVKDPVSRTPALVFEHVNNTD-FKQLYQT--LTDYDIRFYMYEILKA 143 ++R P ++TL + L+ +++N + F L Q T+++++ Y+ EI+ A Sbjct: 114 HIRQSPFLVTLHYAFQTETKL--HLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLA 171 Query: 144 LDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQE--YNVRVASRYFKGP 200 L++ H +GI++RD+K N+++D + + L D+GL+ EF E Y+ Y Sbjct: 172 LEHLHKLGIIYRDIKLENILLD-SNGHVVLTDFGLSKEFVADETERAYDFCGTIEYMAPD 230 Query: 201 ELLVDYQMYDYSLDMWSLGCMLASMIFRKEPF 232 + +D ++D WSLG ++ ++ PF Sbjct: 231 IVRGGDSGHDKAVDWWSLGVLMYELLTGASPF 262 >3LLT-A nrPDB Length = 360 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 58/246 (23%), Positives = 111/246 (45%), Gaps = 36/246 (14%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK--KKIKREIKILENLRGGPN 93 + + ++RK+G G + V +I N + VK+++ +KK + K E IL+ ++ Sbjct: 34 NNAFLVIRKMGDGTFGRVLLCQHIDNKKYYAVKVVRNIKKYTRSAKIEADILKKIQNDDI 93 Query: 94 IITLADIVKDPVSRTP--ALVFEHVNNTDFKQL----YQTLTDYDIRFYMYEILKALDYC 147 L+FE + + ++ + Y DI+ Y EILKAL+Y Sbjct: 94 NNNNIVKYHGKFMYYDHMCLIFEPLGPSLYEIITRNNYNGFHIEDIKLYCIEILKALNYL 153 Query: 148 HSMGIMHRDVKPHNVMIDHEHRK------------------------LRLIDWGLAEFYH 183 M + H D+KP N+++D + + ++LID+G A F Sbjct: 154 RKMSLTHTDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRTKSTGIKLIDFGCATF-- 211 Query: 184 PGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLV 243 + + +R ++ PE++++ +D S DMWS GC+LA + + F H++ + L Sbjct: 212 KSDYHGSIINTRQYRAPEVILNLG-WDVSSDMWSFGCVLAEL-YTGSLLFRTHEHMEHLA 269 Query: 244 RIAKVL 249 + ++ Sbjct: 270 MMESII 275 >6ED6-A nrPDB Length = 415 Score = 73.6 bits (179), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 62/214 (28%), Positives = 105/214 (49%), Gaps = 25/214 (11%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKR-------EIKILENLR 89 +DY +V+ +GRG + EV + + + +K+L K + IKR E + + Sbjct: 88 EDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLS--KFEMIKRSDSAFFWEERDIMAFA 145 Query: 90 GGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDI-----RFYMYEILKAL 144 P ++ L +D R +V E++ D L +++YD+ +FY E++ AL Sbjct: 146 NSPWVVQLFYAFQD--DRYLYMVMEYMPGGDLVNL---MSNYDVPEKWAKFYTAEVVLAL 200 Query: 145 DYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEY-NVRVASRYFKGPEL 202 D HSMG++HRDVKP N+++D +H L+L D+G + G + + V + + PE+ Sbjct: 201 DAIHSMGLIHRDVKPDNMLLD-KHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEV 259 Query: 203 LVDY---QMYDYSLDMWSLGCMLASMIFRKEPFF 233 L Y D WS+G L M+ PF+ Sbjct: 260 LKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFY 293 >3TXO-A nrPDB Length = 353 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 59/206 (28%), Positives = 97/206 (47%), Gaps = 14/206 (6%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP---VKKKKIK---REIKILENLRG 90 D+++ +R LG+G + +V A + VK+LK ++ ++ E +IL R Sbjct: 23 DNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARN 82 Query: 91 GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYD---IRFYMYEILKALDYC 147 P + L + P V E VN D Q +D RFY EI+ AL + Sbjct: 83 HPFLTQLFCCFQTP--DRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFL 140 Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLVDY 206 H GI++RD+K NV++DHE +L D+G+ E G + + PE+L + Sbjct: 141 HDKGIIYRDLKLDNVLLDHEGH-CKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQE- 198 Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPF 232 +Y ++D W++G +L M+ PF Sbjct: 199 MLYGPAVDWWAMGVLLYEMLCGHAPF 224 >3HDN-A nrPDB Length = 373 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 84/360 (23%), Positives = 151/360 (41%), Gaps = 67/360 (18%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL--KPVKKKKIKREIK-----ILENLRG 90 D+ ++ +G+G + +V A + VK+L K + KKK ++ I +L+N++ Sbjct: 39 DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKH 98 Query: 91 GPNIITLADIVKDPVSRTPALVFEHVNNTDF---KQLYQTLTDYDIRFYMYEILKALDYC 147 P ++ L + + V +++N + Q + + RFY EI AL Y Sbjct: 99 -PFLVGLHFSFQ--TADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYL 155 Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELL---- 203 HS+ I++RD+KP N+++D + + L D+GL + E+N S + PE L Sbjct: 156 HSLNIVYRDLKPENILLDSQGH-IVLTDFGLCK---ENIEHN-STTSTFCGTPEYLAPEV 210 Query: 204 VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNI 263 + Q YD ++D W LG +L M++ PF+ + T ++YD I + Sbjct: 211 LHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRN--------------TAEMYDNILNKPL 256 Query: 264 ELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAR----EAM 319 +L P ++ A L+ LL+ D RL A+ E Sbjct: 257 QLKPN------------------------ITNSARHLLEGLLQKDRTKRLGAKDDFMEIK 292 Query: 320 EHPYFYTVVKD---QARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLGPLAGSPVIAAA 376 H +F + D ++ P S P + + P P+ +G S ++ A+ Sbjct: 293 SHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNAIGKAPDSVLVTAS 352 >3DB8-A nrPDB Length = 317 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 53/204 (25%), Positives = 109/204 (53%), Gaps = 15/204 (7%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNE----KVVVK--ILKPVKKKKIKREIKILENLRGGP 92 Y R LG+G +++ +E ++ E KVV K +LKP +K+K+ EI I ++L P Sbjct: 44 YMRGRFLGKGGFAKCYEITDMDTKEVFAGKVVPKSMLLKPHQKEKMSTEIAIHKSL-DNP 102 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ---TLTDYDIRFYMYEILKALDYCHS 149 +++ +D +V E +L++ +T+ + R++M + ++ + Y H+ Sbjct: 103 HVVGFHGFFED--DDFVYVVLEICRRRSLLELHKRRKAVTEPEARYFMRQTIQGVQYLHN 160 Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLVDYQM 208 ++HRD+K N+ ++ + +++ D+GLA + G+ + + PE+L + Sbjct: 161 NRVIHRDLKLGNLFLNDDM-DVKIGDFGLATKIEFDGERKKDLCGTPNYIAPEVLCK-KG 218 Query: 209 YDYSLDMWSLGCMLASMIFRKEPF 232 + + +D+WSLGC+L +++ K PF Sbjct: 219 HSFEVDIWSLGCILYTLLVGKPPF 242 >4B8L-A nrPDB Length = 286 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 71/296 (23%), Positives = 128/296 (43%), Gaps = 53/296 (17%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL------KPVKKKKIKREIKILENLRG 90 DD+ + R LG+GK+ V+ A N + +K+L K + +++REI+I +LR Sbjct: 15 DDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRREIEIQSHLRH 74 Query: 91 GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIR---FYMYEILKALDYC 147 PNI+ + + D + L+ E + + Q +D + +M E+ AL YC Sbjct: 75 -PNILRMYNYFHD--RKRIYLMLEFAPRGELYKELQKHGRFDEQRSATFMEELADALHYC 131 Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQ 207 H ++HRD+KP N+++ ++ +L++ D+G + + P + + PE +++ + Sbjct: 132 HERKVIHRDIKPENLLMGYKG-ELKIADFGWS-VHAPSLRRRTMCGTLDYLPPE-MIEGK 188 Query: 208 MYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDP 267 +D +D+W G + + P F + + RI V D Sbjct: 189 THDEKVDLWCAGVLCYEFLVGMPP-FDSPSHTETHRRIVNV-----------------DL 230 Query: 268 RFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323 +F L S+ D + KLLRY RL + MEHP+ Sbjct: 231 KFPPFLSDGSK--------------------DLISKLLRYHPPQRLPLKGVMEHPW 266 >5D7A-A nrPDB Length = 308 Score = 72.8 bits (177), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 73/309 (23%), Positives = 133/309 (43%), Gaps = 57/309 (18%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPV--KKKKIKREIKILENLRGGPNIIT 96 ++LV +G G Y +V++ ++ + +K++ ++++IK+EI +L+ NI T Sbjct: 19 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIAT 78 Query: 97 L--ADIVKDP--VSRTPALVFEHVNNTDFKQLYQ-----TLTDYDIRFYMYEILKALDYC 147 A I K+P + LV E L + TL + I + EIL+ L + Sbjct: 79 YYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHL 138 Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGL-AEFYHPGQEYNVRVASRYFKGPELLVDY 206 H ++HRD+K NV++ E+ +++L+D+G+ A+ N + + Y+ PE++ Sbjct: 139 HQHKVIHRDIKGQNVLLT-ENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACD 197 Query: 207 Q----MYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYN 262 + YD+ D+WSLG + I G L D Sbjct: 198 ENPDATYDFKSDLWSLG----------------------ITAIEMAEGAPPLCDMHPMRA 235 Query: 263 IELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHP 322 + L PR + R K+W + S F++ L +H R + M+HP Sbjct: 236 LFLIPR--NPAPRLKSKKWSKKFQS------------FIESCLVKNHSQRPATEQLMKHP 281 Query: 323 YFYTVVKDQ 331 + ++DQ Sbjct: 282 F----IRDQ 286 >3DLS-A nrPDB Length = 335 Score = 72.4 bits (176), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 61/224 (27%), Positives = 103/224 (45%), Gaps = 27/224 (12%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK-----------KKIKREIKILEN 87 Y + LG G + V+ A++ N++VVVK +K K K+ EI IL Sbjct: 26 YSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSR 85 Query: 88 LRGGPNIITLADIVKDPVSRTPALVFE-HVNNTDF-------KQLYQTLTDYDIRFYMYE 139 + NII + DI ++ LV E H + D +L + L Y R + Sbjct: 86 VEHA-NIIKVLDIFEN--QGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASYIFR----Q 138 Query: 140 ILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKG 199 ++ A+ Y I+HRD+K N++I E ++LID+G A + G+ + + + Sbjct: 139 LVSAVGYLRLKDIIHRDIKDENIVI-AEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCA 197 Query: 200 PELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLV 243 PE+L+ L+MWSLG L +++F + PF + + + Sbjct: 198 PEVLMGNPYRGPELEMWSLGVTLYTLVFEENPFCELEETVEAAI 241 >3UDB-A nrPDB Length = 317 Score = 72.0 bits (175), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 52/204 (25%), Positives = 102/204 (50%), Gaps = 9/204 (4%) Query: 35 NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK--KKIKREIKILENLRGGP 92 + D Y+LV+ +G G + + NE V VK ++ +K + +KREI +LR P Sbjct: 17 DSDRYELVKDIGAGNFGVARLMRDKQANELVAVKYIERGEKIDENVKREIINHRSLRH-P 75 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNTD-FKQLYQT--LTDYDIRFYMYEILKALDYCHS 149 NI+ +++ P A+V E+ + + F+++ ++ + RF+ +++ + Y H+ Sbjct: 76 NIVRFKEVILTPTHL--AIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYAHA 133 Query: 150 MGIMHRDVKPHNVMIDHEHR-KLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQM 208 M + HRD+K N ++D +L++ D+G ++ + V + + PE+L+ + Sbjct: 134 MQVAHRDLKLENTLLDGSPAPRLKIADFGYSKASVLHSQPKSAVGTPAYIAPEVLLKKEY 193 Query: 209 YDYSLDMWSLGCMLASMIFRKEPF 232 D+WS G L M+ PF Sbjct: 194 DGKVADVWSCGVTLYVMLVGAYPF 217 >5F9E-A nrPDB Length = 353 Score = 72.0 bits (175), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 57/213 (26%), Positives = 102/213 (47%), Gaps = 19/213 (8%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIIT 96 +D++L + LG+G + +VF A N+ +K LK K + +E +++ Sbjct: 19 EDFELHKMLGKGSFGKVFLAEFKKTNQFFAIKALK----KDVVLMDDDVECTMVEKRVLS 74 Query: 97 LA--------DIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIR---FYMYEILKALD 145 LA V E++N D Q+ +D+ FY EI+ L Sbjct: 75 LAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQ 134 Query: 146 YCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ-EYNVRVASRYFKGPELLV 204 + HS GI++RD+K N+++D + +++ D+G+ + G + N + + PE+L+ Sbjct: 135 FLHSKGIVYRDLKLDNILLDKDGH-IKIADFGMCKENMLGDAKTNEFCGTPDYIAPEILL 193 Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHD 237 Q Y++S+D WS G +L M+ + P FHG D Sbjct: 194 G-QKYNHSVDWWSFGVLLYEMLIGQSP-FHGQD 224 >4FIE-A nrPDB Length = 423 Score = 71.6 bits (174), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 52/198 (26%), Positives = 85/198 (42%), Gaps = 38/198 (19%) Query: 128 LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGL-AEFYHPGQ 186 + + I +L+AL H+ G++HRD+K ++++ H+ R ++L D+G A+ Sbjct: 244 MNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGR-VKLSDFGFCAQVSKEVP 302 Query: 187 EYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIA 246 V + Y+ PEL+ Y +D+WSLG M+ M+ + P+F+ Sbjct: 303 RRKSLVGTPYWMAPELISRLP-YGPEVDIWSLGIMVIEMVDGEPPYFN------------ 349 Query: 247 KVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLR 306 E + L PR +N H VSP FLD+LL Sbjct: 350 -----EPPLKAMKMIRDNLPPRL------------------KNLHKVSPSLKGFLDRLLV 386 Query: 307 YDHQSRLTAREAMEHPYF 324 D R TA E ++HP+ Sbjct: 387 RDPAQRATAAELLKHPFL 404 >3Q53-A nrPDB Length = 306 Score = 71.6 bits (174), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 67/294 (22%), Positives = 131/294 (44%), Gaps = 50/294 (17%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVK---ILKPVKKKKIKREIKILENLRGGPNII 95 Y K+G+G V+ A+++ ++V ++ + + KK+ I EI ++ + PNI+ Sbjct: 23 YTRFEKIGQGASGTVYTAMDVATGQEVAIRQMNLQQQPKKELIINEILVMRENKN-PNIV 81 Query: 96 TLAD--IVKDPVSRTPALVFEHVNNTDFKQLYQ--TLTDYDIRFYMYEILKALDYCHSMG 151 D +V D + +V E++ + + + I E L+AL++ HS Sbjct: 82 NYLDSYLVGDEL----WVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQ 137 Query: 152 IMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ-EYNVRVASRYFKGPELLVDYQMYD 210 ++HRD+K N+++ + ++L D+G P Q + + V + Y+ PE +V + Y Sbjct: 138 VIHRDIKSDNILLGMDG-SVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPE-VVTRKAYG 195 Query: 211 YSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFN 270 +D+WSLG M MI + P+ ++N + + + GT +L Sbjct: 196 PKVDIWSLGIMAIEMIEGEPPYL--NENPLRALYLIATNGTPEL---------------- 237 Query: 271 DILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 +N +S DFL++ L D + R +A+E ++H + Sbjct: 238 -----------------QNPEKLSAIFRDFLNRCLEMDVEKRGSAKELIQHQFL 274 >6E9W-A nrPDB Length = 443 Score = 71.6 bits (174), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 64/216 (29%), Positives = 103/216 (47%), Gaps = 29/216 (13%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKR-------EIKILENLR 89 +DY++V+ +GRG + EV + + + +K+L K + IKR E + + Sbjct: 102 EDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLS--KFEMIKRSDSAFFWEERDIMAFA 159 Query: 90 GGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDI-----RFYMYEILKAL 144 P ++ L +D R +V E++ D L +++YD+ RFY E++ AL Sbjct: 160 NSPWVVQLFYAFQD--DRYLYMVMEYMPGGDLVNL---MSNYDVPEKWARFYTAEVVLAL 214 Query: 145 DYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVR----VASRYFKGP 200 D HSMG +HRDVKP N+++D L+L D+G +E VR V + + P Sbjct: 215 DAIHSMGFIHRDVKPDNMLLDKSGH-LKLADFGTC--MKMNKEGMVRCDTAVGTPDYISP 271 Query: 201 ELLVDY---QMYDYSLDMWSLGCMLASMIFRKEPFF 233 E+L Y D WS+G L M+ PF+ Sbjct: 272 EVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFY 307 >3ORP-A nrPDB Length = 311 Score = 71.2 bits (173), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 58/213 (27%), Positives = 100/213 (46%), Gaps = 20/213 (9%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK------PVKKKKIKREIKILENLR 89 D Y+L LG G SEV A ++ ++ V VK+L+ P + +RE + L Sbjct: 11 SDRYELGEILGFGGMSEVHLARDLRDHRDVAVKVLRADLARDPSFYLRFRREAQNAAALN 70 Query: 90 GGPNIITLADI--VKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKAL 144 P I+ + D + P P +V E+V+ + + T +T + + +AL Sbjct: 71 H-PAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIVHTEGPMTPKRAIEVIADACQAL 129 Query: 145 DYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPG-----QEYNVRVASRYFKG 199 ++ H GI+HRDVKP N+MI + ++++D+G+A Q V ++Y Sbjct: 130 NFSHQNGIIHRDVKPANIMISATN-AVKVMDFGIARAIADSGNSVTQTAAVIGTAQYLSP 188 Query: 200 PELLVDYQMYDYSLDMWSLGCMLASMIFRKEPF 232 + D D D++SLGC+L ++ + PF Sbjct: 189 EQARGDS--VDARSDVYSLGCVLYEVLTGEPPF 219 >3QA8-A nrPDB Length = 676 Score = 71.2 bits (173), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 57/212 (26%), Positives = 100/212 (47%), Gaps = 20/212 (9%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKI----LKPVKKKKIKREIKILENLRGGPNI 94 +++ +LG G + V I+ E+V +K L P +++ EI+I++ L PN+ Sbjct: 16 WEMKERLGTGGFGYVLRWIHQDTGEQVAIKQCRQELSPKNRERWCLEIQIMKKL-NHPNV 74 Query: 95 ITLADIVKDPVSRT-----PALVFEHVNNTDFKQLYQT------LTDYDIRFYMYEILKA 143 ++ A V D + + P L E+ D ++ L + IR + +I A Sbjct: 75 VS-AREVPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGPIRTLLSDISSA 133 Query: 144 LDYCHSMGIMHRDVKPHNVMIDHEHRKL--RLIDWGLAEFYHPGQEYNVRVASRYFKGPE 201 L Y H I+HRD+KP N+++ ++L ++ID G A+ G+ V + + PE Sbjct: 134 LRYLHENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQGELCTEFVGTLQYLAPE 193 Query: 202 LLVDYQMYDYSLDMWSLGCMLASMIFRKEPFF 233 LL + + Y ++D WS G + I PF Sbjct: 194 LL-EQKKYTVTVDYWSFGTLAFECITGFRPFL 224 >4TNB-A nrPDB Length = 590 Score = 70.9 bits (172), Expect = 9e-13, Method: Compositional matrix adjust. Identities = 72/262 (27%), Positives = 123/262 (46%), Gaps = 28/262 (10%) Query: 35 NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKR---------EIKIL 85 ++ ++ R LG+G + EV A + K+ K ++KK+IK+ E +IL Sbjct: 182 TKNTFRQYRVLGKGGFGEVC-ACQVRATGKMYA--CKRLEKKRIKKRKGESMALNEKQIL 238 Query: 86 ENLRGGPNIITLADI--VKDPVSRTPALVFEHVNNTDFK-QLYQT----LTDYDIRFYMY 138 E + ++ LA KD + LV +N D K +Y + FY Sbjct: 239 EKV-NSQFVVNLAYAYETKDAL----CLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAA 293 Query: 139 EILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFK 198 EIL L+ H ++RD+KP N+++D ++ +R+ D GLA G RV + + Sbjct: 294 EILCGLEDLHHENTVYRDLKPENILLD-DYGHIRISDLGLAVKIPEGDLIRGRVGTVGYM 352 Query: 199 GPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYI 258 PE+L + Q Y S D W LGC++ MI + PF + + +VL TE++Y + Sbjct: 353 APEVL-NNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSH- 410 Query: 259 DKYNIELDPRFNDILGRHSRKR 280 K++ E +L + +++R Sbjct: 411 -KFSEEAKSICKMLLTKDAKQR 431 >4JDH-A nrPDB Length = 346 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 52/198 (26%), Positives = 85/198 (42%), Gaps = 38/198 (19%) Query: 128 LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGL-AEFYHPGQ 186 + + I +L+AL H+ G++HRD+K ++++ H+ R ++L D+G A+ Sbjct: 167 MNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGR-VKLSDFGFCAQVSKEVP 225 Query: 187 EYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIA 246 V + Y+ PEL+ Y +D+WSLG M+ M+ + P+F+ Sbjct: 226 RRKSLVGTPYWMAPELISRLP-YGPEVDIWSLGIMVIEMVDGEPPYFN------------ 272 Query: 247 KVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLR 306 E + L PR +N H VSP FLD+LL Sbjct: 273 -----EPPLKAMKMIRDNLPPRL------------------KNLHKVSPSLKGFLDRLLV 309 Query: 307 YDHQSRLTAREAMEHPYF 324 D R TA E ++HP+ Sbjct: 310 RDPAQRATAAELLKHPFL 327 >6HXF-B nrPDB Length = 302 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 75/304 (24%), Positives = 138/304 (45%), Gaps = 47/304 (15%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKR---EIKILENLRGGPNII 95 +++V +LG G + +V++A N K+++ +++++ EI+IL P I+ Sbjct: 21 WEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATC-DHPYIV 79 Query: 96 TLADIVKDPVSRTPALVFEHVNNTD--FKQLYQTLTDYDIRFYMYEILKALDYCHSMGIM 153 L + F D +L + LT+ I+ ++L+AL++ HS I+ Sbjct: 80 KLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKRII 139 Query: 154 HRDVKPHNVMIDHEHRKLRLIDWGL-AEFYHPGQEYNVRVASRYFKGPELLVDYQM---- 208 HRD+K NV++ E +RL D+G+ A+ Q+ + + + Y+ PE+++ M Sbjct: 140 HRDLKAGNVLMTLEG-DIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTP 198 Query: 209 YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPR 268 YDY D+WSLG L M + EP H + L++IAK Sbjct: 199 YDYKADIWSLGITLIEMA-QIEPPHHELNPMRVLLKIAK--------------------- 236 Query: 269 FNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVV 328 +D + +W S E DFL L + ++R +A + +EHP+ ++ Sbjct: 237 -SDPPTLLTPSKW------------SVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSIT 283 Query: 329 KDQA 332 ++A Sbjct: 284 SNKA 287 >1FOT-A nrPDB Length = 318 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 53/204 (25%), Positives = 106/204 (51%), Gaps = 14/204 (6%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP---VKKKKIK--REIKILENLRGGP 92 D+Q++R LG G + V + N +K+LK V+ K+++ + +++ ++ P Sbjct: 7 DFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTHP 66 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCHS 149 II + +D ++ ++ +++ + L Q + +FY E+ AL+Y HS Sbjct: 67 FIIRMWGTFQD--AQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYLHS 124 Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMY 209 I++RD+KP N+++D ++ +++ D+G A+ Y P Y + Y PE +V + Y Sbjct: 125 KDIIYRDLKPENILLD-KNGHIKITDFGFAK-YVPDVTYTLCGTPDYI-APE-VVSTKPY 180 Query: 210 DYSLDMWSLGCMLASMIFRKEPFF 233 + S+D WS G ++ M+ PF+ Sbjct: 181 NKSIDWWSFGILIYEMLAGYTPFY 204 >4AF3-A nrPDB Length = 292 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 64/243 (26%), Positives = 125/243 (51%), Gaps = 23/243 (9%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL------KPVKKKKIKREIKILENLRG 90 DD+++ R LG+GK+ V+ A ++ V +K+L K + +++REI+I +L Sbjct: 23 DDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHH 82 Query: 91 GPNIITLADIVKDPVSRTPALVFEHVNNTD-FKQLYQTLTDYDIRF--YMYEILKALDYC 147 PNI+ L + D R L+ E+ + +K+L ++ T + R M E+ AL YC Sbjct: 83 -PNILRLYNYFYD--RRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYC 139 Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQ 207 H ++HRD+KP N+++ +L++ D+G + + P + + PE +++ + Sbjct: 140 HGKKVIHRDIKPENLLLG-LKGELKIADFGWS-VHAPSLRRKTMCGTLDYLPPE-MIEGR 196 Query: 208 MYDYSLDMWSLGCMLASMIFRKEPFFHGHDN--YDQLVRI-----AKV-LGTEDLYDYID 259 M++ +D+W +G + ++ PF N Y ++V++ A V G +DL + Sbjct: 197 MHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPTGAQDLISKLL 256 Query: 260 KYN 262 ++N Sbjct: 257 RHN 259 >4KIK-B nrPDB Length = 677 Score = 70.1 bits (170), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 54/211 (25%), Positives = 94/211 (44%), Gaps = 18/211 (8%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKI----LKPVKKKKIKREIKILENLRGGPNI 94 +++ +LG G + V N E++ +K L P +++ EI+I+ L PN+ Sbjct: 21 WEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQIMRRL-THPNV 79 Query: 95 ITLADIVKDPVSRTP----ALVFEHVNNTDFKQLYQT------LTDYDIRFYMYEILKAL 144 + D+ + + P L E+ D ++ L + I + +I AL Sbjct: 80 VAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASAL 139 Query: 145 DYCHSMGIMHRDVKPHNVMIDHEHRKL--RLIDWGLAEFYHPGQEYNVRVASRYFKGPEL 202 Y H I+HRD+KP N+++ ++L ++ID G A+ G V + + PEL Sbjct: 140 RYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPEL 199 Query: 203 LVDYQMYDYSLDMWSLGCMLASMIFRKEPFF 233 L + Q Y ++D WS G + I PF Sbjct: 200 L-EQQKYTVTVDYWSFGTLAFECITGFRPFL 229 >2Q0N-A nrPDB Length = 301 Score = 70.1 bits (170), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 52/198 (26%), Positives = 85/198 (42%), Gaps = 38/198 (19%) Query: 128 LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGL-AEFYHPGQ 186 + + I +L+AL H+ G++HRD+K ++++ H+ R ++L D+G A+ Sbjct: 122 MNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGR-VKLSDFGFCAQVSKEVP 180 Query: 187 EYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIA 246 V + Y+ PE L+ Y +D+WSLG M+ M+ + P+F+ Sbjct: 181 RRKSLVGTPYWMAPE-LISRLPYGPEVDIWSLGIMVIEMVDGEPPYFN------------ 227 Query: 247 KVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLR 306 E + L PR +N H VSP FLD+LL Sbjct: 228 -----EPPLKAMKMIRDNLPPRL------------------KNLHKVSPSLKGFLDRLLV 264 Query: 307 YDHQSRLTAREAMEHPYF 324 D R TA E ++HP+ Sbjct: 265 RDPAQRATAAELLKHPFL 282 >6DBM-A nrPDB Length = 318 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 57/199 (28%), Positives = 97/199 (48%), Gaps = 17/199 (8%) Query: 42 VRKLGRGKYSEV----FEAINITNNEKVVVKILK----PVKKKKIKREIKILENLRGGPN 93 +R LG G + +V ++ N E V VK LK P + K+EI IL L + Sbjct: 36 IRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAGPQHRSGWKQEIDILRTLYH-EH 94 Query: 94 IITLADIVKDPVSRTPALVFEHVNNTDFKQLY--QTLTDYDIRFYMYEILKALDYCHSMG 151 II +D + + LV E+V + ++ + + +I + + Y HS Sbjct: 95 IIKYKGCCEDAGAASLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHSQH 154 Query: 152 IMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE-YNVRV---ASRYFKGPELLVDYQ 207 +HRD+ NV++D++ R +++ D+GLA+ G E Y VR + ++ PE L +Y+ Sbjct: 155 YIHRDLAARNVLLDND-RLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYK 213 Query: 208 MYDYSLDMWSLGCMLASMI 226 Y Y+ D+WS G L ++ Sbjct: 214 FY-YASDVWSFGVTLYELL 231 >2OU7-A nrPDB Length = 335 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 51/198 (25%), Positives = 106/198 (53%), Gaps = 15/198 (7%) Query: 45 LGRGKYSEVFEAINITNNE----KVVVK--ILKPVKKKKIKREIKILENLRGGPNIITLA 98 LG+G +++ FE + E K+V K +LKP +++K+ EI I +L +++ Sbjct: 49 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSL-AHQHVVGFH 107 Query: 99 DIVKDPVSRTPALVFEHVNNTDFKQLYQ---TLTDYDIRFYMYEILKALDYCHSMGIMHR 155 +D + +V E +L++ LT+ + R+Y+ +I+ Y H ++HR Sbjct: 108 GFFED--NDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHR 165 Query: 156 DVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLD 214 D+K N+ ++ E ++++ D+GLA + + G+ V + + PE+L + + + +D Sbjct: 166 DLKLGNLFLN-EDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVL-SKKGHSFEVD 223 Query: 215 MWSLGCMLASMIFRKEPF 232 +WS+GC++ +++ K PF Sbjct: 224 VWSIGCIMYTLLVGKPPF 241 >2JDO-A nrPDB Length = 342 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 74/309 (23%), Positives = 132/309 (42%), Gaps = 60/309 (19%) Query: 35 NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP---VKKKKIKR---EIKILENL 88 +D+ ++ LG+G + +V +KIL+ + K ++ E ++L+N Sbjct: 8 TMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNT 67 Query: 89 RGGPNIITLADIVKDPVSRTPALVFEHVNNTD-FKQLYQ--TLTDYDIRFYMYEILKALD 145 R P + L + V E+ N + F L + T+ RFY EI+ AL+ Sbjct: 68 RH-PFLTALKYAFQ--THDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALE 124 Query: 146 YCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLV 204 Y HS +++RD+K N+M+D + +++ D+GL E G + + PE+L Sbjct: 125 YLHSRDVVYRDIKLENLMLDKDGH-IKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLE 183 Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPFF-HGHDNYDQLVRIAKVLGTEDLYDYIDKYNI 263 D Y ++D W LG ++ M+ + PF+ H+ +L+ + ++ Sbjct: 184 DND-YGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEI--------------- 227 Query: 264 ELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRL-----TAREA 318 RF + +SPEA L LL+ D + RL A+E Sbjct: 228 -------------------RFPRT-----LSPEAKSLLAGLLKKDPKQRLGGGPSDAKEV 263 Query: 319 MEHPYFYTV 327 MEH +F ++ Sbjct: 264 MEHRFFLSI 272 >4QMW-A nrPDB Length = 310 Score = 69.3 bits (168), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 57/200 (28%), Positives = 98/200 (49%), Gaps = 13/200 (6%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKIL----KPVKKKKIKREIKILENLRGGPNI 94 + + K+G+G + EVF+ I+ + V +KI+ + + I++EI +L Sbjct: 31 FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVT 90 Query: 95 ITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT--LTDYDIRFYMYEILKALDYCHSMGI 152 +KD ++ E++ L + L + I + EILK LDY HS Sbjct: 91 KYYGSYLKD---TKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLHSEKK 147 Query: 153 MHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ-EYNVRVASRYFKGPELLVDYQMYDY 211 +HRD+K NV++ EH +++L D+G+A Q + N V + ++ PE ++ YD Sbjct: 148 IHRDIKAANVLLS-EHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPE-VIKQSAYDS 205 Query: 212 SLDMWSLGCMLASMIFRKEP 231 D+WSLG + A + R EP Sbjct: 206 KADIWSLG-ITAIELARGEP 224 >6CQF-A nrPDB Length = 297 Score = 69.3 bits (168), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 59/216 (27%), Positives = 105/216 (48%), Gaps = 25/216 (11%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK---KKIKREIKILENLRGGP 92 +D Y L+++LG G Y EVF+A + + + V +K++K +++EI IL+ R Sbjct: 15 RDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRH-- 72 Query: 93 NIITLADIVKDPVS----RTPALVFEHVNNTDFKQLYQ---TLTDYDIRFYMYEILKALD 145 A+IV S + + E + +YQ +L++ I + E+L+ L Sbjct: 73 -----ANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLA 127 Query: 146 YCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVA---SRYFKGPEL 202 Y HS +HRD+K N++I+ + ++RL D+G++ G R+A + Y+ PE+ Sbjct: 128 YLHSQKKIHRDIKGANILIN-DAGEVRLADFGISA--QIGATLARRLAFIGTPYWMAPEV 184 Query: 203 --LVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGH 236 + Y+ D+WSLG + + P F H Sbjct: 185 AAVALKGGYNELCDIWSLGITAIELAELQPPLFDVH 220 >4KS7-A nrPDB Length = 292 Score = 69.3 bits (168), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 53/198 (26%), Positives = 91/198 (45%), Gaps = 38/198 (19%) Query: 128 LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGL-AEFYHPGQ 186 L + I +L+AL Y H+ G++HRD+K ++++ + R ++L D+G A+ Sbjct: 116 LNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGR-VKLSDFGFCAQISKDVP 174 Query: 187 EYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIA 246 + V + Y+ PE ++ +Y +D+WSLG M+ M+ + P+F D V+ Sbjct: 175 KRKSLVGTPYWMAPE-VISRSLYATEVDIWSLGIMVIEMVDGEPPYFS-----DSPVQAM 228 Query: 247 KVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLR 306 K L P+ +N H VSP DFL+++L Sbjct: 229 KRLRDSP------------PPKL------------------KNSHKVSPVLRDFLERMLV 258 Query: 307 YDHQSRLTAREAMEHPYF 324 D Q R TA+E ++HP+ Sbjct: 259 RDPQERATAQELLDHPFL 276 >4J52-A nrPDB Length = 293 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 51/198 (25%), Positives = 106/198 (53%), Gaps = 15/198 (7%) Query: 45 LGRGKYSEVFEAINITNNE----KVVVK--ILKPVKKKKIKREIKILENLRGGPNIITLA 98 LG+G +++ FE + E K+V K +LKP +++K+ EI I +L +++ Sbjct: 22 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSL-AHQHVVGFH 80 Query: 99 DIVKDPVSRTPALVFEHVNNTDFKQLYQ---TLTDYDIRFYMYEILKALDYCHSMGIMHR 155 +D + +V E +L++ LT+ + R+Y+ +I+ Y H ++HR Sbjct: 81 GFFED--NDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHR 138 Query: 156 DVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLD 214 D+K N+ ++ E ++++ D+GLA + + G+ V + + PE+L + + + +D Sbjct: 139 DLKLGNLFLN-EDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVL-SKKGHSFEVD 196 Query: 215 MWSLGCMLASMIFRKEPF 232 +WS+GC++ +++ K PF Sbjct: 197 VWSIGCIMYTLLVGKPPF 214 >4OLI-A nrPDB Length = 645 Score = 68.9 bits (167), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 59/220 (26%), Positives = 105/220 (47%), Gaps = 17/220 (7%) Query: 42 VRKLGRGKYSEV----FEAINITNNEKVVVKILK----PVKKKKIKREIKILENLRGGPN 93 +R LG G + +V ++ N E V VK LK P + K+EI IL L + Sbjct: 358 IRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYH-EH 416 Query: 94 IITLADIVKDPVSRTPALVFEHVNNTDFKQLY--QTLTDYDIRFYMYEILKALDYCHSMG 151 II +D ++ LV E+V + ++ + + +I + + Y HS Sbjct: 417 IIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHSQH 476 Query: 152 IMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE-YNVRV---ASRYFKGPELLVDYQ 207 +HR++ NV++D++ R +++ D+GLA+ G E Y VR + ++ PE L +Y+ Sbjct: 477 YIHRNLAARNVLLDND-RLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYK 535 Query: 208 MYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAK 247 Y Y+ D+WS G L ++ + + +L+ IA+ Sbjct: 536 FY-YASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQ 574 >6BDL-A nrPDB Length = 347 Score = 68.6 bits (166), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 53/206 (25%), Positives = 103/206 (50%), Gaps = 17/206 (8%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEK--VVVKILK------PVKKKKIKREIKILENLR 89 D+ ++ LG G + V E + + + E +KILK +++ I+ E +I++ Sbjct: 35 DFNIIDTLGVGGFGRV-ELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAH 93 Query: 90 GGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ---TLTDYDIRFYMYEILKALDY 146 I+ L KD S+ ++ E + + + + D RFY +++A Y Sbjct: 94 S-DFIVRLYRTFKD--SKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAY 150 Query: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDY 206 HS GI++RD+KP N+++DH +L+D+G A+ G++ + + PE++++ Sbjct: 151 LHSKGIIYRDLKPENLILDHRGYA-KLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILN- 208 Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPF 232 + +D S D WSLG ++ ++ PF Sbjct: 209 KGHDISADYWSLGILMYELLTGSPPF 234 >4XBR-A nrPDB Length = 366 Score = 68.6 bits (166), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 52/198 (26%), Positives = 85/198 (42%), Gaps = 38/198 (19%) Query: 128 LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGL-AEFYHPGQ 186 + + I +L+AL H+ G++HRD+K ++++ H+ R ++L D+G A+ Sbjct: 187 MNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGR-VKLSDFGFCAQVSKEVP 245 Query: 187 EYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIA 246 V + Y+ PE L+ Y +D+WSLG M+ M+ + P+F+ Sbjct: 246 RRKSLVGTPYWMAPE-LISRLPYGPEVDIWSLGIMVIEMVDGEPPYFN------------ 292 Query: 247 KVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLR 306 E + L PR +N H VSP FLD+LL Sbjct: 293 -----EPPLKAMKMIRDNLPPRL------------------KNLHKVSPSLKGFLDRLLV 329 Query: 307 YDHQSRLTAREAMEHPYF 324 D R TA E ++HP+ Sbjct: 330 RDPAQRATAAELLKHPFL 347 >4EQM-A nrPDB Length = 294 Score = 68.2 bits (165), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 61/218 (27%), Positives = 105/218 (48%), Gaps = 20/218 (9%) Query: 28 SHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL------KPVKKKKIKRE 81 SH++ + Y++V KLG G S V+ A + N KV +K + K K+ +RE Sbjct: 2 SHMIGKIINERYKIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETLKRFERE 61 Query: 82 IKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----LTDYDIRFYM 137 + L NI+++ D+ D LV E++ + ++ D I F Sbjct: 62 VHNSSQL-SHQNIVSMIDV--DEEDDCYYLVMEYIEGPTLSEYIESHGPLSVDTAINF-T 117 Query: 138 YEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHP---GQEYNVRVAS 194 +IL + + H M I+HRD+KP N++ID ++ L++ D+G+A+ Q +V Sbjct: 118 NQILDGIKHAHDMRIVHRDIKPQNILID-SNKTLKIFDFGIAKALSETSLTQTNHVLGTV 176 Query: 195 RYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPF 232 +YF PE + D D++S+G +L M+ + PF Sbjct: 177 QYF-SPE-QAKGEATDECTDIYSIGIVLYEMLVGEPPF 212 >2XNP-A nrPDB Length = 279 Score = 68.2 bits (165), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 56/215 (26%), Positives = 99/215 (46%), Gaps = 23/215 (10%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVV------KILKPVKKKKIKREIKILENLRG 90 +DY+++ +G G Y + I ++ K++V + +K+ + E+ +L L+ Sbjct: 6 EDYEVLYTIGTGSYGRC-QKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKH 64 Query: 91 GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY-------QTLTDYDIRFYMYEILKA 143 PNI+ D + D + T +V E+ D + Q L + + M ++ A Sbjct: 65 -PNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLA 123 Query: 144 LDYCHSMG-----IMHRDVKPHNVMIDHEHRKLRLIDWGLAEFY-HPGQEYNVRVASRYF 197 L CH ++HRD+KP NV +D + ++L D+GLA H V + Y+ Sbjct: 124 LKECHRRSDGGHTVLHRDLKPANVFLDGKQ-NVKLGDFGLARILNHDTSFAKTFVGTPYY 182 Query: 198 KGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPF 232 PE + + Y+ D+WSLGC+L + PF Sbjct: 183 MSPEQM-NRMSYNEKSDIWSLGCLLYELCALMPPF 216 >3DAK-A nrPDB Length = 290 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 55/217 (25%), Positives = 102/217 (47%), Gaps = 21/217 (9%) Query: 35 NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK----KIKREIKILENLRG 90 N+DDY+L +G G + V A EKV +K + K + ++ +EI+ + Sbjct: 8 NRDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCHH 67 Query: 91 GPNIIT--LADIVKDPVSRTPAL-----VFEHVNNTDFKQLYQT--LTDYDIRFYMYEIL 141 PNI++ + +VKD + L V + + + K +++ L + I + E+L Sbjct: 68 -PNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVL 126 Query: 142 KALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKG-- 199 + L+Y H G +HRDVK N+++ E +++ D+G++ F G + + F G Sbjct: 127 EGLEYLHKNGQIHRDVKAGNILLG-EDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTP 185 Query: 200 ----PELLVDYQMYDYSLDMWSLGCMLASMIFRKEPF 232 PE++ + YD+ D+WS G + P+ Sbjct: 186 CWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPY 222 >1ZXE-A nrPDB Length = 303 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 67/267 (25%), Positives = 125/267 (46%), Gaps = 52/267 (19%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK--KIKREIKILENL------R 89 D++ + LG+G + +V +A N ++ +K ++ ++K I E+ +L +L R Sbjct: 7 DFEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRHTEEKLSTILSEVMLLASLNHQYVVR 66 Query: 90 GGPNIITLADIVKDPVS--RTPALVFEHVNNTDFKQLYQTLTDYDI--------RFYMYE 139 + + VK P++ + + +F + + + LY + ++ R + + Sbjct: 67 YYAAWLERRNFVK-PMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQRDEYWRLFR-Q 124 Query: 140 ILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH-------------PGQ 186 IL+AL Y HS GI+HR++KP N+ ID E R +++ D+GLA+ H PG Sbjct: 125 ILEALSYIHSQGIIHRNLKPMNIFID-ESRNVKIGDFGLAKNVHRSLDILKLDSQNLPGS 183 Query: 187 EYNVR--VASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVR 244 N+ + + + E+L Y+ +DM+SLG + MI+ PF G + + L + Sbjct: 184 SDNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMIY---PFSTGMERVNILKK 240 Query: 245 IAKVLGTEDLYDYIDKYNIELDPRFND 271 + V +IE P F+D Sbjct: 241 LRSV-------------SIEFPPDFDD 254 >3M42-A nrPDB Length = 299 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 55/210 (26%), Positives = 97/210 (46%), Gaps = 34/210 (16%) Query: 37 DDYQLVRK-LGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNII 95 DDY++ + LG G +V + N EK +K+L+ K + RE+++ P+I+ Sbjct: 17 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKAR--REVELHWRASQCPHIV 74 Query: 96 TLADIVKDPVSRTPAL--VFEHVNNTD-FKQLY----QTLTDYDIRFYMYEILKALDYCH 148 + D+ ++ + L V E ++ + F ++ Q T+ + M I +A+ Y H Sbjct: 75 RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 134 Query: 149 SMGIMHRDVKPHNVMIDHE--HRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDY 206 S+ I HRDVKP N++ + + L+L D+G A+ Sbjct: 135 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKE----------------------TTG 172 Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGH 236 + YD S DMWSLG ++ ++ PF+ H Sbjct: 173 EKYDKSCDMWSLGVIMYILLCGYPPFYSNH 202 >4NFN-A nrPDB Length = 309 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 39/153 (25%), Positives = 81/153 (52%), Gaps = 6/153 (3%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKI-KREIKILENLRGGPNI 94 +D +++++K+G G + E++EA+++ E V +K+ + K++ K E+ +L+ L+G ++ Sbjct: 20 KDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDHV 79 Query: 95 ITLADIVKDPVSRTPALVFEHVNNTDFK--QLYQTLTDYDIRFYMYEILKALDYCHSMGI 152 ++ + + N D + Q T T +IL++++ HS+G Sbjct: 80 CRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHSVGF 139 Query: 153 MHRDVKPHNVMIDH---EHRKLRLIDWGLAEFY 182 +HRD+KP N + +RK ++D+GLA Y Sbjct: 140 LHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQY 172 >4BTK-A nrPDB Length = 337 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 39/153 (25%), Positives = 81/153 (52%), Gaps = 6/153 (3%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKI-KREIKILENLRGGPNI 94 +D +++++K+G G + E++EA+++ E V +K+ + K++ K E+ +L+ L+G ++ Sbjct: 55 KDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDHV 114 Query: 95 ITLADIVKDPVSRTPALVFEHVNNTDFK--QLYQTLTDYDIRFYMYEILKALDYCHSMGI 152 ++ + + N D + Q T T +IL++++ HS+G Sbjct: 115 CRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHSVGF 174 Query: 153 MHRDVKPHNVMIDH---EHRKLRLIDWGLAEFY 182 +HRD+KP N + +RK ++D+GLA Y Sbjct: 175 LHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQY 207 >4WUA-A nrPDB Length = 401 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 93/383 (24%), Positives = 160/383 (41%), Gaps = 83/383 (21%) Query: 20 PREYWDYESHVVEWGN--QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK--K 75 P +Y H+V+ G+ Y ++RKLG G +S V+ + +I + V +K++K + Sbjct: 22 PNDYCKGGYHLVKIGDLFNGRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYT 81 Query: 76 KKIKREIKILENLRGG----PN---IITLADIVK-DPVSRT-PALVFE----HVNNTDFK 122 + EI++L+++R PN ++ L D K V+ T +VFE H+ K Sbjct: 82 ETALDEIRLLKSVRNSDPNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIK 141 Query: 123 QLYQTLTDYDIRFYMYEILKALDYCHSMG-IMHRDVKPHNVMI----------------- 164 YQ L ++ + ++L+ LDY H+ I+H D+KP N+++ Sbjct: 142 SNYQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEW 201 Query: 165 -------------------------------DHEHRKLRLIDWGLAEFYHPGQEYNVRVA 193 + E K+++ D G A + H + + + Sbjct: 202 QRSGAPPPSGSAVSTAPATAGNFLVNPLEPKNAEKLKVKIADLGNACWVH--KHFTEDIQ 259 Query: 194 SRYFKGPELLVDYQMYDYSLDMWSLGCM---LASMIFRKEPFFHGHDNY----DQLVRIA 246 +R ++ E+L+ Y+ D+WS CM LA+ + EP H + Y D + I Sbjct: 260 TRQYRSLEVLIG-SGYNTPADIWSTACMAFELATGDYLFEP--HSGEEYTRDEDHIALII 316 Query: 247 KVLGTEDLYDYI-DKYNIELDPRFNDILGRHSRKRWERF-VHSENQHLVSPEA---LDFL 301 ++LG + KY+ E + D+ K W F V E EA DFL Sbjct: 317 ELLGKVPRKLIVAGKYSKEFFTKKGDLKHITKLKPWGLFEVLVEKYEWSQEEAAGFTDFL 376 Query: 302 DKLLRYDHQSRLTAREAMEHPYF 324 +L + R TA E + HP+ Sbjct: 377 LPMLELIPEKRATAAECLRHPWL 399 >3IS5-A nrPDB Length = 285 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 65/305 (21%), Positives = 132/305 (43%), Gaps = 54/305 (17%) Query: 34 GNQDD-YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP----VKKKKIKREIKILENL 88 G DD + RKLG G + +V ++ + V+K + V ++I+ EI++L++L Sbjct: 18 GTIDDLFIFKRKLGSGAFGDVHLVEERSSGLERVIKTINKDRSQVPMEQIEAEIEVLKSL 77 Query: 89 RGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY-------QTLTDYDIRFYMYEIL 141 PNII + ++ +D +V E + + + L++ + M +++ Sbjct: 78 -DHPNIIKIFEVFED--YHNMYIVMETCEGGELLERIVSAQARGKALSEGYVAELMKQMM 134 Query: 142 KALDYCHSMGIMHRDVKPHNVMIDHE--HRKLRLIDWGLAEFYHPGQEYNVRVASRYFKG 199 AL Y HS ++H+D+KP N++ H +++ID+GLAE + + + + Sbjct: 135 NALAYFHSQHVVHKDLKPENILFQDTSPHSPIKIIDFGLAELFKSDEHSTNAAGTALYMA 194 Query: 200 PELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYID 259 PE+ + + D+WS G ++ ++ PF L + + ++ Sbjct: 195 PEVF--KRDVTFKCDIWSAGVVMYFLLTGCLPF-----TGTSLEEVQQKATYKE-----P 242 Query: 260 KYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAM 319 Y +E P ++P+A+D L ++L D + R +A + + Sbjct: 243 NYAVECRP-------------------------LTPQAVDLLKQMLTKDPERRPSAAQVL 277 Query: 320 EHPYF 324 H +F Sbjct: 278 HHEWF 282 >3PFQ-A nrPDB Length = 674 Score = 66.2 bits (160), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 65/225 (28%), Positives = 102/225 (45%), Gaps = 19/225 (8%) Query: 34 GNQD-----DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP-VKKKKIKREIKILEN 87 GN+D D+ + LG+G + +V + +E VKILK V + E ++E Sbjct: 333 GNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEK 392 Query: 88 ----LRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYD---IRFYMYEI 140 L G P +T + R V E+VN D Q + + FY EI Sbjct: 393 RVLALPGKPPFLTQLHSCFQTMDRL-YFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEI 451 Query: 141 LKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKG 199 L + S GI++RD+K NVM+D E +++ D+G+ E G + + Sbjct: 452 AIGLFFLQSKGIIYRDLKLDNVMLDSEGH-IKIADFGMCKENIWDGVTTKTFCGTPDYIA 510 Query: 200 PELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVR 244 PE++ YQ Y S+D W+ G +L M+ + P F G D D+L + Sbjct: 511 PEIIA-YQPYGKSVDWWAFGVLLYEMLAGQAP-FEGEDE-DELFQ 552 >4U41-A nrPDB Length = 332 Score = 65.9 bits (159), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 56/214 (26%), Positives = 98/214 (45%), Gaps = 17/214 (7%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK--IKREIKILENLRGGPNIIT 96 ++LV +G G Y +V++ ++ + +K++ + ++ IK EI +L+ NI T Sbjct: 26 FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKKYSHHRNIAT 85 Query: 97 L--ADIVKDPVSRTPAL--VFEHVNNTDFKQLYQ-----TLTDYDIRFYMYEILKALDYC 147 A I K P L V E L + TL + I + EIL+ L + Sbjct: 86 YYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAHL 145 Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGL-AEFYHPGQEYNVRVASRYFKGPELLVDY 206 H ++HRD+K NV++ E+ +++L+D+G+ A+ N + + Y+ PE++ Sbjct: 146 HIHHVIHRDIKGQNVLLT-ENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACD 204 Query: 207 Q----MYDYSLDMWSLGCMLASMIFRKEPFFHGH 236 + YDY D+WS G M P H Sbjct: 205 ENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMH 238 >2I0E-A nrPDB Length = 353 Score = 65.9 bits (159), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 65/225 (28%), Positives = 102/225 (45%), Gaps = 19/225 (8%) Query: 34 GNQD-----DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP-VKKKKIKREIKILEN 87 GN+D D+ + LG+G + +V + +E VKILK V + E ++E Sbjct: 12 GNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEK 71 Query: 88 ----LRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYD---IRFYMYEI 140 L G P +T + R V E+VN D Q + + FY EI Sbjct: 72 RVLALPGKPPFLTQLHSCFQTMDRL-YFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEI 130 Query: 141 LKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKG 199 L + S GI++RD+K NVM+D E +++ D+G+ E G + + Sbjct: 131 AIGLFFLQSKGIIYRDLKLDNVMLDSEGH-IKIADFGMCKENIWDGVTTKTFCGTPDYIA 189 Query: 200 PELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVR 244 PE++ YQ Y S+D W+ G +L M+ + P F G D D+L + Sbjct: 190 PEIIA-YQPYGKSVDWWAFGVLLYEMLAGQAP-FEGEDE-DELFQ 231 >5KCV-A nrPDB Length = 460 Score = 65.5 bits (158), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 80/308 (25%), Positives = 132/308 (42%), Gaps = 59/308 (19%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP---VKKKKIKR---EIKILENLRG 90 ++++ ++ LG+G + +V +KILK V K ++ E ++L+N R Sbjct: 162 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 221 Query: 91 GPNIITLADIVKDPVSRTPALVFEHVNNTD-FKQLYQ--TLTDYDIRFYMYEILKALDYC 147 P + L + V E+ N + F L + ++ RFY EI+ ALDY Sbjct: 222 -PFLTALKYSFQ--THDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYL 278 Query: 148 HS-MGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLVD 205 HS +++RD+K N+M+D + +++ D+GL E G + + PE+L D Sbjct: 279 HSEKNVVYRDLKLENLMLDKDGH-IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLED 337 Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIEL 265 Y ++D W LG ++ M+ + PF+ N D E L++ I I Sbjct: 338 ND-YGRAVDWWGLGVVMYEMMCGRLPFY----NQDH----------EKLFELILMEEI-- 380 Query: 266 DPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT-----AREAME 320 RF LG PEA L LL+ D + RL A+E M+ Sbjct: 381 --RFPRTLG--------------------PEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQ 418 Query: 321 HPYFYTVV 328 H +F +V Sbjct: 419 HRFFAGIV 426 >2UV2-A nrPDB Length = 325 Score = 65.1 bits (157), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 76/308 (24%), Positives = 134/308 (43%), Gaps = 47/308 (15%) Query: 26 YESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKR---EI 82 YE + +D ++++ +LG G + +V++A N + K++ +++++ EI Sbjct: 26 YEHVTRDLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEI 85 Query: 83 KILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTD--FKQLYQTLTDYDIRFYMYEI 140 IL + PNI+ L D + + F D +L + LT+ I+ + Sbjct: 86 DILASC-DHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQT 144 Query: 141 LKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGL-AEFYHPGQEYNVRVASRYFKG 199 L AL+Y H I+HRD+K N++ + ++L D+G+ A+ Q + + + Y+ Sbjct: 145 LDALNYLHDNKIIHRDLKAGNILFTLDG-DIKLADFGVSAKNTRTIQRRDSFIGTPYWMA 203 Query: 200 PELLVDYQM----YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLY 255 PE+++ YDY D+WSLG L M EP H + L++IAK Sbjct: 204 PEVVMCETSKDRPYDYKADVWSLGITLIEMA-EIEPPHHELNPMRVLLKIAKS------- 255 Query: 256 DYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTA 315 +P L + S RW S DFL K L + +R T Sbjct: 256 ----------EPP---TLAQPS--RW------------SSNFKDFLKKCLEKNVDARWTT 288 Query: 316 REAMEHPY 323 + ++HP+ Sbjct: 289 SQLLQHPF 296 >5FET-A nrPDB Length = 847 Score = 65.1 bits (157), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 45/138 (32%), Positives = 79/138 (57%), Gaps = 8/138 (5%) Query: 134 RFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVA 193 +FY+ I+ A++Y H I++RD+KP N+++D + ++LID+G A+ G+ Y + V Sbjct: 636 QFYLGSIILAIEYLHERNIVYRDLKPENILLDKQGY-VKLIDFGCAKKIQ-GRAYTL-VG 692 Query: 194 SRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVL-GTE 252 + ++ PE+++ + Y ++D+W+LG L I PF G+D DQL +L G Sbjct: 693 TPHYMAPEVILG-KGYGCTVDIWALGVCLYEFICGPLPF--GNDQEDQLEIFRDILTGQL 749 Query: 253 DLYDYI-DKYNIELDPRF 269 DY+ D+ +I L R Sbjct: 750 TFPDYVSDQDSINLMKRL 767 >3C51-A nrPDB Length = 543 Score = 65.1 bits (157), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 59/212 (27%), Positives = 89/212 (41%), Gaps = 42/212 (19%) Query: 135 FYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVAS 194 FY +I+ L++ H I++RD+KP NV++D + +R+ D GLA GQ A Sbjct: 293 FYTAQIVSGLEHLHQRNIIYRDLKPENVLLDDDG-NVRISDLGLAVELKAGQTKTKGYAG 351 Query: 195 R-YFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTED 253 F PELL+ + YD+S+D ++LG L MI + PF + + +VL E Sbjct: 352 TPGFMAPELLLG-EEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKQRVL--EQ 408 Query: 254 LYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRL 313 Y DK+ SP + DF + LL+ D + RL Sbjct: 409 AVTYPDKF--------------------------------SPASKDFCEALLQKDPEKRL 436 Query: 314 TAREAM-----EHPYFYTVVKDQARMGSSSMP 340 R+ HP F + Q G + P Sbjct: 437 GFRDGSCDGLRTHPLFRDISWRQLEAGMLTPP 468 >5DYK-A nrPDB Length = 853 Score = 64.7 bits (156), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 38/115 (33%), Positives = 69/115 (60%), Gaps = 6/115 (5%) Query: 128 LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE 187 L+ +FY+ I+ A++Y H I++RD+KP N+++D + ++LID+G A+ G+ Sbjct: 636 LSKSQAQFYLGSIILAIEYLHERNIVYRDLKPENILLDKQGY-VKLIDFGCAKKVQ-GRA 693 Query: 188 YNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQL 242 Y + V + ++ PE+++ + Y ++D+W+LG L I PF G+D DQL Sbjct: 694 YTL-VGTPHYMAPEVILG-KGYGCTVDIWALGICLYEFICGPLPF--GNDEEDQL 744 >3MV5-A nrPDB Length = 342 Score = 64.7 bits (156), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 76/309 (24%), Positives = 133/309 (43%), Gaps = 61/309 (19%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP---VKKKKIKR---EIKILENLRG 90 ++++ ++ LG+G + +V +KILK V K ++ E ++L+N R Sbjct: 10 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 69 Query: 91 GPNIITLADIVKDPVSRTPALVFEHVNNTD-FKQLYQ--TLTDYDIRFYMYEILKALDYC 147 P + L + V E+ N + F L + ++ RFY EI+ ALDY Sbjct: 70 -PFLTALKYSFQ--THDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYL 126 Query: 148 HS-MGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLVD 205 HS +++RD+K N+M+D + +++ D+GL E G + + PE+L D Sbjct: 127 HSEKNVVYRDLKLENLMLDKDGH-IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLED 185 Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFH-GHDNYDQLVRIAKVLGTEDLYDYIDKYNIE 264 Y ++D W LG ++ M+ + PF++ H+ +L+ + ++ Sbjct: 186 ND-YGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEI---------------- 228 Query: 265 LDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRL-----TAREAM 319 RF LG PEA L LL+ D + RL A+E M Sbjct: 229 ---RFPRTLG--------------------PEAKSLLSGLLKKDPKQRLGGGSEDAKEIM 265 Query: 320 EHPYFYTVV 328 +H +F +V Sbjct: 266 QHRFFAGIV 274 >3COM-A nrPDB Length = 314 Score = 64.7 bits (156), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 52/205 (25%), Positives = 98/205 (47%), Gaps = 13/205 (6%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK--KKIKREIKILENLRGGPNIIT 96 + ++ KLG G Y V++AI+ + V +K + PV+ ++I +EI I++ + Sbjct: 31 FDVLEKLGEGSYGSVYKAIHKETGQIVAIKQV-PVESDLQEIIKEISIMQQCDSPHVVKY 89 Query: 97 LADIVKDPVSRTPALVFEHVNNTDFKQLY----QTLTDYDIRFYMYEILKALDYCHSMGI 152 K+ +V E+ + +TLT+ +I + LK L+Y H M Sbjct: 90 YGSYFKN---TDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRK 146 Query: 153 MHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLVDYQMYDY 211 +HRD+K N++++ E +L D+G+A + + N + + ++ PE++ + Y+ Sbjct: 147 IHRDIKAGNILLNTEGHA-KLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIG-YNC 204 Query: 212 SLDMWSLGCMLASMIFRKEPFFHGH 236 D+WSLG M K P+ H Sbjct: 205 VADIWSLGITAIEMAEGKPPYADIH 229 >6CCF-A nrPDB Length = 290 Score = 64.3 bits (155), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 57/254 (22%), Positives = 112/254 (44%), Gaps = 45/254 (17%) Query: 76 KKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY--QTLTDYDI 133 +++ +EI IL+ L N++ L +++ DP LVF+ + ++ + ++ Sbjct: 73 ERVYQEIAILKKL-DHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEVPCDKPFSEEQA 131 Query: 134 RFYMYEILKALDYCHSMGIMHRDVKPHNVMI-DHEHRKLRLIDWGLA-EFYHPGQEYNVR 191 R Y+ +++ L+Y H I+HRD+KP N+++ D H +++ D+G++ +F + + Sbjct: 132 RLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGH--VKIADFGVSNQFEGNDAQLSST 189 Query: 192 VASRYFKGPELLVD--YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVL 249 + F PE + D +LD+W+ G L ++ K PF Sbjct: 190 AGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPF----------------- 232 Query: 250 GTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDH 309 ID + IL H + + E V E +S E D + K+L + Sbjct: 233 --------IDDF----------ILALHRKIKNEPVVFPEEPE-ISEELKDLILKMLDKNP 273 Query: 310 QSRLTAREAMEHPY 323 ++R+ + HP+ Sbjct: 274 ETRIGVPDIKLHPW 287 >6DBN-A nrPDB Length = 316 Score = 64.3 bits (155), Expect = 9e-11, Method: Compositional matrix adjust. Identities = 55/201 (27%), Positives = 97/201 (48%), Gaps = 19/201 (9%) Query: 42 VRKLGRGKYSEV----FEAINITNNEKVVVKILKPVKKKK----IKREIKILENLRGGPN 93 +R LG G + +V ++ E+V VK LKP +K+EI+IL NL N Sbjct: 40 IRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYH-EN 98 Query: 94 IITLADIVKDPVSRTPALVFEHVNNTDFKQ-LYQTLTDYDIR---FYMYEILKALDYCHS 149 I+ I + L+ E + + K+ L + +++ Y +I K +DY S Sbjct: 99 IVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGS 158 Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEY----NVRVASRYFKGPELLVD 205 +HRD+ NV+++ EH+ +++ D+GL + +EY + R + ++ PE L+ Sbjct: 159 RQYVHRDLAARNVLVESEHQ-VKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQ 217 Query: 206 YQMYDYSLDMWSLGCMLASMI 226 + Y S D+WS G L ++ Sbjct: 218 SKFYIAS-DVWSFGVTLHELL 237 >5N23-A nrPDB Length = 352 Score = 64.3 bits (155), Expect = 9e-11, Method: Compositional matrix adjust. Identities = 54/216 (25%), Positives = 104/216 (48%), Gaps = 13/216 (6%) Query: 26 YESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL---KPVKKKKIKREI 82 +ES + D ++ +R LG G + V + +KIL K VK K+I+ + Sbjct: 31 WESPAQNTAHLDQFERIRTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTL 90 Query: 83 --KILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTD-FKQLYQT--LTDYDIRFYM 137 K ++ P ++ L KD + +V E+ + F L + ++ RFY Sbjct: 91 NEKRIQQAVNFPFLVKLEFSFKD--NSNLYMVLEYAPGGEMFSHLRRIGRFSEPHARFYA 148 Query: 138 YEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYF 197 +I+ +Y HS+ +++RD+KP N++ID + +++ D+G A+ + + Y Sbjct: 149 AQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY-IKVADFGFAKRVKGRTPWTLCGTPEYL 207 Query: 198 KGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFF 233 PE+++ + Y+ ++D W+LG ++ M PFF Sbjct: 208 -APEIILS-KGYNKAVDWWALGVLIYEMAAGYPPFF 241 >4RA4-A nrPDB Length = 355 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 58/204 (28%), Positives = 90/204 (44%), Gaps = 12/204 (5%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP-VKKKKIKREIKILEN----LRGGP 92 D+ + LG+G + +V A E +KILK V + E ++E L P Sbjct: 21 DFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKP 80 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDY---DIRFYMYEILKALDYCHS 149 +T V R V E+VN D Q + + FY EI L + H Sbjct: 81 PFLTQLHSCFQTVDRL-YFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHK 139 Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLVDYQM 208 GI++RD+K NVM+D E +++ D+G+ E G + + PE++ YQ Sbjct: 140 RGIIYRDLKLDNVMLDSEGH-IKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIA-YQP 197 Query: 209 YDYSLDMWSLGCMLASMIFRKEPF 232 Y S+D W+ G +L M+ + PF Sbjct: 198 YGKSVDWWAYGVLLYEMLAGQPPF 221 >4AW2-A nrPDB Length = 437 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 56/215 (26%), Positives = 101/215 (46%), Gaps = 22/215 (10%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVV-------KILKPVKKKKIKREIKILENL 88 ++D+++++ +GRG + EV + + N +KV ++LK + + E +L N Sbjct: 73 REDFEILKVIGRGAFGEV-AVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVN- 130 Query: 89 RGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDY----DIRFYMYEILKAL 144 I TL +D LV ++ D L D RFY+ E++ A+ Sbjct: 131 GDSKWITTLHYAFQD--DNNLYLVMDYYVGGDLLTLLSKFEDRLPEEMARFYLAEMVIAI 188 Query: 145 DYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWG-LAEFYHPGQ-EYNVRVASRYFKGPEL 202 D H + +HRD+KP N+++D + +RL D+G + G + +V V + + PE+ Sbjct: 189 DSVHQLHYVHRDIKPDNILMDM-NGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEI 247 Query: 203 LVDYQ----MYDYSLDMWSLGCMLASMIFRKEPFF 233 L + Y D WSLG + M++ + PF+ Sbjct: 248 LQAMEGGKGRYGPECDWWSLGVCMYEMLYGETPFY 282 >4IAN-A nrPDB Length = 358 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 33/114 (28%), Positives = 64/114 (56%), Gaps = 4/114 (3%) Query: 133 IRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRV 192 +R Y ++ AL I+H D+KP N++++ L+L D+G A + + + Sbjct: 137 VRSYSQQLFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSAS-HVADNDITPYL 195 Query: 193 ASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIA 246 SR+++ PE+++ + YDY +DMWS+GC L + + + F G N + ++++A Sbjct: 196 VSRFYRAPEIIIG-KSYDYGIDMWSVGCTLYEL-YTGKILFPGKTN-NHMLKLA 246 >6E2O-A nrPDB Length = 295 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 59/231 (25%), Positives = 108/231 (46%), Gaps = 21/231 (9%) Query: 19 RPREYWDYESHVVEWGNQDDYQLVRK-LGRGKYSEVFEAINITNNEKVVVKILKPVKKKK 77 R E D ES ++E+ + D R LG+G Y V+ +++N ++ +K + P + + Sbjct: 3 RSTEEGDCESDLLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEI-PERDSR 61 Query: 78 ----IKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----LT 129 + EI + ++L+ + L ++ + + E V L ++ L Sbjct: 62 YSQPLHEEIALHKHLKHKNIVQYLGSFSENGFIK---IFMEQVPGGSLSALLRSKWGPLK 118 Query: 130 DYD--IRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE---FYHP 184 D + I FY +IL+ L Y H I+HRD+K NV+I+ L++ D+G ++ +P Sbjct: 119 DNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINP 178 Query: 185 GQEYNVRVASRYFKGPELL-VDYQMYDYSLDMWSLGCMLASMIFRKEPFFH 234 E + + PE++ + Y + D+WSLGC + M K PF+ Sbjct: 179 CTE--TFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYE 227 >4WB7-A nrPDB Length = 405 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 57/217 (26%), Positives = 109/217 (50%), Gaps = 16/217 (7%) Query: 26 YESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL---KPVKKKKIK--- 79 +ES + D ++ ++ LG G + V + +KIL K VK K+I+ Sbjct: 85 WESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTL 144 Query: 80 REIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTD-FKQLYQT--LTDYDIRFY 136 E +IL+ + P ++ L KD + +V E+V + F L + ++ RFY Sbjct: 145 NEKRILQAV-NFPFLVKLEFSFKD--NSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFY 201 Query: 137 MYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY 196 +I+ +Y HS+ +++RD+KP N++ID + +++ D+G A+ G+ + + Y Sbjct: 202 AAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY-IQVTDFGFAKRVK-GRTWTLCGTPEY 259 Query: 197 FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFF 233 PE+++ + Y+ ++D W+LG ++ M PFF Sbjct: 260 L-APEIILS-KGYNKAVDWWALGVLIYEMAAGYPPFF 294 >5FQD-C nrPDB Length = 341 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 47/149 (31%), Positives = 78/149 (52%), Gaps = 6/149 (4%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKI-LKPVKKKKIKREIKILENLRGGPNI--I 95 Y+LVRK+G G + +++ AINITN E+V VK+ + + ++ E K+ + L+GG I I Sbjct: 21 YKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIPHI 80 Query: 96 TLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHR 155 KD L+ + + F + T + +++ ++Y H+ +HR Sbjct: 81 RWYGQEKDYNVLVMDLLGPSLEDL-FNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHR 139 Query: 156 DVKPHNVM--IDHEHRKLRLIDWGLAEFY 182 D+KP N + I KL LID+GLA+ Y Sbjct: 140 DIKPDNFLMGIGRHCNKLFLIDFGLAKKY 168 >4X3F-A nrPDB Length = 337 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 52/208 (25%), Positives = 97/208 (46%), Gaps = 17/208 (8%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILK------PVKKKKIKREIKILENLRGGP 92 Y+L R + G +V+EA++ +V VK+LK P ++ + E + L P Sbjct: 14 YRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNH-P 72 Query: 93 NIITLADIVKDPV---SRTPALVFEHVNNTDFKQLYQTLTDYDIRF---YMYEILKALDY 146 I ++ D + + RT LV E VN + + +R + + +AL Sbjct: 73 GIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQI 132 Query: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFY--HPGQEYNVRVASRYFKGPELLV 204 H+ G++HRDVKP N++I ++++ D+G+A+ P + + + + + PE + Sbjct: 133 AHAAGLVHRDVKPGNILITPTG-QVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQAL 191 Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPF 232 + S D++SLG + + K PF Sbjct: 192 GHDASPAS-DVYSLGVVGYEAVSGKRPF 218 >5TQX-A nrPDB Length = 655 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 52/218 (23%), Positives = 99/218 (45%), Gaps = 17/218 (7%) Query: 32 EWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKI----LKPVKKKKIKREIKILEN 87 E+G +++ +LG G + V + + K+ +K L +++ EI+I++ Sbjct: 3 EFGAGGPWEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCHEIQIMKK 62 Query: 88 LRGGPNIITLADIVKDP---VSRTPALVFEHVNNTDFKQLYQT------LTDYDIRFYMY 138 L N++ D+ ++ + P L E+ + D ++L L + I + Sbjct: 63 LNHA-NVVKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLS 121 Query: 139 EILKALDYCHSMGIMHRDVKPHNVMIDHEHRKL--RLIDWGLAEFYHPGQEYNVRVASRY 196 +I + Y H I+HRD+KP N+++ K+ ++ID G A+ G+ V + Sbjct: 122 DIGSGIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGELCTEFVGTLQ 181 Query: 197 FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFH 234 + PEL + + Y ++D WS G M+ I PF H Sbjct: 182 YLAPELF-ENKPYTATVDYWSFGTMVFECIAGYRPFLH 218 >5X3F-B nrPDB Length = 393 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 55/206 (26%), Positives = 105/206 (50%), Gaps = 16/206 (7%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL---KPVKKKKIK---REIKILENLRG 90 D + ++ LG G + V + + +KIL K VK K+I+ E +IL+ + Sbjct: 84 DQFDRIKTLGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAV-N 142 Query: 91 GPNIITLADIVKDPVSRTPALVFEHVNNTD-FKQLYQT--LTDYDIRFYMYEILKALDYC 147 P ++ L KD + +V E+V + F L + ++ RFY +I+ +Y Sbjct: 143 FPFLVKLEFSFKD--NSNLYMVMEYVAGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYL 200 Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQ 207 HS+ +++RD+KP N++ID + +++ D+G A+ G+ + + Y PE+++ + Sbjct: 201 HSLDLIYRDLKPENLLIDQQGY-IQVTDFGFAKRVK-GRTWTLCGTPEYL-APEIILS-K 256 Query: 208 MYDYSLDMWSLGCMLASMIFRKEPFF 233 Y+ ++D W+LG ++ M PFF Sbjct: 257 GYNKAVDWWALGVLIYEMAAGYPPFF 282 >2WTK-C nrPDB Length = 305 Score = 62.8 bits (151), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 72/298 (24%), Positives = 124/298 (41%), Gaps = 61/298 (20%) Query: 45 LGRGKYSEVFEAINITNNEKVVVKILK-------PVKKKKIKREIKILENLRGGPNIITL 97 LG G Y +V E ++ + VKILK P + +K+EI++L LR N+I L Sbjct: 13 LGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRH-KNVIQL 71 Query: 98 ADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRF-------YMYEILKALDYCHSM 150 D++ + + +V E+ +++ ++ + RF Y +++ L+Y HS Sbjct: 72 VDVLYNEEKQKMYMVMEYCV-CGMQEMLDSVPEK--RFPVCQAHGYFCQLIDGLEYLHSQ 128 Query: 151 GIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHP-GQEYNVRVA--SRYFKGPELLVDYQ 207 GI+H+D+KP N+++ L++ G+AE HP + R + S F+ PE+ Sbjct: 129 GIVHKDIKPGNLLLT-TGGTLKISALGVAEALHPFAADDTCRTSQGSPAFQPPEIANGLD 187 Query: 208 MYD-YSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 266 + + +D+WS G L ++ P F G + Y I K Y I D Sbjct: 188 TFSGFKVDIWSAGVTLYNITTGLYP-FEGDNIYKLFENIGK-----------GSYAIPGD 235 Query: 267 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 P D L +L Y+ R + R+ +H +F Sbjct: 236 --------------------------CGPPLSDLLKGMLEYEPAKRFSIRQIRQHSWF 267 >4OW8-A nrPDB Length = 283 Score = 62.8 bits (151), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 52/208 (25%), Positives = 98/208 (47%), Gaps = 17/208 (8%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILK------PVKKKKIKREIKILENLRGGP 92 Y+L R + G +V+EA++ +V VK+LK P ++ + E + L P Sbjct: 13 YRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNH-P 71 Query: 93 NIITLADIVKDPVS---RTPALVFEHVNNTDFKQLYQTLTDYDIRF---YMYEILKALDY 146 I ++ D + ++ RT LV E VN + + +R + + +AL Sbjct: 72 GIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQI 131 Query: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFY--HPGQEYNVRVASRYFKGPELLV 204 H+ G++HRDVKP N++I ++++ D+G+A+ P + + + + + PE + Sbjct: 132 AHAAGLVHRDVKPGNILITPTG-QVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQAL 190 Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPF 232 + S D++SLG + + K PF Sbjct: 191 GHDASPAS-DVYSLGVVGYEAVSGKRPF 217 >2XIK-A nrPDB Length = 294 Score = 62.8 bits (151), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 61/218 (27%), Positives = 104/218 (47%), Gaps = 20/218 (9%) Query: 28 SHVVEWGNQ----DDYQLVRKL---GRGKYSEVFEAINITNNEKVVVKIL----KPVKKK 76 +H+ + NQ D +L KL G+G + EV++ I+ E V +KI+ + + Sbjct: 3 AHLRGFANQHSRVDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIE 62 Query: 77 KIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT--LTDYDIR 134 I++EI +L +K S ++ E++ L + L + I Sbjct: 63 DIQQEITVLSQCDSPYITRYFGSYLK---STKLWIIMEYLGGGSALDLLKPGPLEETYIA 119 Query: 135 FYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ-EYNVRVA 193 + EILK LDY HS +HRD+K NV++ E ++L D+G+A Q + N V Sbjct: 120 TILREILKGLDYLHSERKIHRDIKAANVLLS-EQGDVKLADFGVAGQLTDTQIKRNTFVG 178 Query: 194 SRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEP 231 + ++ PE ++ YD+ D+WSLG + A + + EP Sbjct: 179 TPFWMAPE-VIKQSAYDFKADIWSLG-ITAIELAKGEP 214 >6B2Q-A nrPDB Length = 317 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 52/208 (25%), Positives = 98/208 (47%), Gaps = 17/208 (8%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILK------PVKKKKIKREIKILENLRGGP 92 Y+L R + G +V+EA++ +V VK+LK P ++ + E + L P Sbjct: 34 YRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNH-P 92 Query: 93 NIITLADIVKDPVS---RTPALVFEHVNNTDFKQLYQTLTDYDIRF---YMYEILKALDY 146 I ++ D + ++ RT LV E VN + + +R + + +AL Sbjct: 93 GIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQI 152 Query: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFY--HPGQEYNVRVASRYFKGPELLV 204 H+ G++HRDVKP N++I ++++ D+G+A+ P + + + + + PE + Sbjct: 153 AHAAGLVHRDVKPGNILITPTG-QVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQAL 211 Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPF 232 + S D++SLG + + K PF Sbjct: 212 GHDASPAS-DVYSLGVVGYEAVSGKRPF 238 >4E20-A nrPDB Length = 290 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 55/216 (25%), Positives = 101/216 (46%), Gaps = 17/216 (7%) Query: 42 VRKLGRGKYSEV----FEAINITNNEKVVVKILK----PVKKKKIKREIKILENLRGGPN 93 +R LG G + +V ++ N E V VK LK P + +REI+IL L + Sbjct: 13 IRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSGWQREIEILRTLYH-EH 71 Query: 94 IITLADIVKDPVSRTPALVFEHVNNTDFKQLY--QTLTDYDIRFYMYEILKALDYCHSMG 151 I+ +D ++ LV E+V + + + + +I + + Y H+ Sbjct: 72 IVKYKGCCEDQGEKSVQLVMEYVPLGSLRDYLPRHCVGLAQLLLFAQQICEGMAYLHAQH 131 Query: 152 IMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE-YNVRV---ASRYFKGPELLVDYQ 207 +HR + NV++D++ R +++ D+GLA+ G E Y VR + ++ PE L + + Sbjct: 132 YIHRALAARNVLLDND-RLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKECK 190 Query: 208 MYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLV 243 Y Y+ D+WS G L ++ + H + +L+ Sbjct: 191 FY-YASDVWSFGVTLYELLTYCDSNQSPHTKFTELI 225 >2PMN-X nrPDB Length = 348 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 77/328 (23%), Positives = 144/328 (43%), Gaps = 72/328 (21%) Query: 37 DDYQLVRKLGRGKYSEV--------FEAI--------------NITNNEKVVVKILKPVK 74 +DY+++R L +GK++++ F A+ +NN+K+ +K K Sbjct: 31 NDYRIIRTLNQGKFNKIILCEKDNKFYALKKYEKSLLEKKRDFTKSNNDKISIK----SK 86 Query: 75 KKKIKREIKILENLRG-----GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLT 129 K E++I+ +++ IIT D V +++E++ N + + Sbjct: 87 YDDFKNELQIITDIKNEYCLTCEGIITNYDEV--------YIIYEYMENDSILKFDEYFF 138 Query: 130 DYD-----------IRFYMYEILKALDYCHS-MGIMHRDVKPHNVMIDHEHRKLRLIDWG 177 D I+ + +L + Y H+ I HRDVKP N+++D R ++L D+G Sbjct: 139 VLDKNYTCFIPIQVIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMDKNGR-VKLSDFG 197 Query: 178 LAEFYHPGQEYNVRVASRYFKGPELLVDYQMYD-YSLDMWSLGCMLASMIFRKEPFFHGH 236 +E Y ++ + F PE + Y+ +D+WSLG L M + PF Sbjct: 198 ESE-YMVDKKIKGSRGTYEFMPPEFFSNESSYNGAKVDIWSLGICLYVMFYNVVPF---- 252 Query: 237 DNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPE 296 ++I+ V +L++ I NIE N L + K+ + + + +S E Sbjct: 253 -----SLKISLV----ELFNNIRTKNIEYPLDRNHFLYPLTNKK-----STCSNNFLSNE 298 Query: 297 ALDFLDKLLRYDHQSRLTAREAMEHPYF 324 +DFL LR + R+T+ +A++H + Sbjct: 299 DIDFLKLFLRKNPAERITSEDALKHEWL 326 >4C59-A nrPDB Length = 340 Score = 62.0 bits (149), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 61/247 (24%), Positives = 114/247 (46%), Gaps = 35/247 (14%) Query: 21 REYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL---KPVKKKK 77 R+ D+ VE G + ++ R L G ++ V+EA ++ + + +K L + K + Sbjct: 12 RDQSDFVGQTVELG-ELRLRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRA 70 Query: 78 IKREIKILENLRGGPNII---TLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIR 134 I +E+ ++ L G PNI+ + A I K+ S T F + QL + L + R Sbjct: 71 IIQEVCFMKKLSGHPNIVQFCSAASIGKEE-SDTGQAEFLLLTELCKGQLVEFLKKMESR 129 Query: 135 F---------YMYEILKALDYCHSMG--IMHRDVKPHNVMIDHEHRKLRLIDWGLAEF-- 181 Y+ +A+ + H I+HRD+K N+++ ++ ++L D+G A Sbjct: 130 GPLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQG-TIKLCDFGSATTIS 188 Query: 182 YHPG-----------QEYNVRVASRYFKGPELLVDYQMYDYS--LDMWSLGCMLASMIFR 228 ++P +E R + ++ PE++ Y + D+W+LGC+L + FR Sbjct: 189 HYPDYSWSAQRRALVEEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFR 248 Query: 229 KEPFFHG 235 + PF G Sbjct: 249 QHPFEDG 255 >3VN9-A nrPDB Length = 340 Score = 62.0 bits (149), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 70/342 (20%), Positives = 143/342 (41%), Gaps = 64/342 (18%) Query: 5 VPSRARVYTDVNTHRPREYWDYESH-VVEWGNQ------DDYQLVRKLGRGKYSEVFEAI 57 +P A ++ PR D +S + GNQ DD + + +LGRG Y V + Sbjct: 15 IPKEAFEQPQTSSTPPR---DLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMR 71 Query: 58 NITNNEKVVVKILKPV----KKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVF 113 ++ + + + VK ++ ++K++ ++ I P +T + + Sbjct: 72 HVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGAL---FREGDVWIC 128 Query: 114 EHVNNTDFKQLY-------QTLTDYDIRFYMYEILKALDYCHS-MGIMHRDVKPHNVMID 165 + +T + Y QT+ + + I+KAL++ HS + ++HRDVKP NV+I Sbjct: 129 MELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLI- 187 Query: 166 HEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELL---VDYQMYDYSLDMWSLGCML 222 + ++++ D+G++ + + + + PE + ++ + Y D+WSLG + Sbjct: 188 NALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITM 247 Query: 223 ASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWE 282 + + P+ + QL ++ + E P+ + Sbjct: 248 IELAILRFPYDSWGTPFQQLKQVVE----------------EPSPQLP----------AD 281 Query: 283 RFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 +F S E +DF + L+ + + R T E M+HP+F Sbjct: 282 KF---------SAEFVDFTSQCLKKNSKERPTYPELMQHPFF 314 >2X7G-A nrPDB Length = 389 Score = 62.0 bits (149), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 88/387 (22%), Positives = 157/387 (40%), Gaps = 81/387 (20%) Query: 14 DVNTHRPREYWDYESHVVEWGN--QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK 71 D P +Y H V+ G+ Y ++RKLG G +S V+ ++ V +K++K Sbjct: 6 DEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVK 65 Query: 72 PVK--KKKIKREIKILENLR----GGPNIITLADIVKD-PVSRTP----ALVFE----HV 116 + + EIK+L+ +R PN + ++ D +S +VFE H+ Sbjct: 66 SAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHL 125 Query: 117 NNTDFKQLYQTLTDYDIRFYMYEILKALDYCHS-MGIMHRDVKPHNVMI----------- 164 K YQ L ++ + ++L+ LDY HS I+H D+KP N+++ Sbjct: 126 LKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMA 185 Query: 165 -----------------------------------DHEHRKLRLIDWGLAEFYHPGQEYN 189 + + ++++ D G A + H + + Sbjct: 186 AEATEWQKAGAPPPSGSAVSTAPAADLLVNPLDPRNADKIRVKIADLGNACWVH--KHFT 243 Query: 190 VRVASRYFKGPELLVDYQMYDYSLDMWSLGCM---LASMIFRKEPFFHGHDNY----DQL 242 + +R ++ E+L+ Y D+WS CM LA+ + EP H ++Y D + Sbjct: 244 EDIQTRQYRSIEVLIGAG-YSTPADIWSTACMAFELATGDYLFEP--HSGEDYSRDEDHI 300 Query: 243 VRIAKVLGT-EDLYDYIDKYNIELDPRFNDILGRHSRKRWERF-VHSEN---QHLVSPEA 297 I ++LG+ + KY+ E R ++ K W F V E H + + Sbjct: 301 AHIIELLGSIPRHFALSGKYSREFFNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQF 360 Query: 298 LDFLDKLLRYDHQSRLTAREAMEHPYF 324 DFL +L + R +A E + HP+ Sbjct: 361 TDFLIPMLEMVPEKRASAGECLRHPWL 387 >3OMV-A nrPDB Length = 307 Score = 62.0 bits (149), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 59/251 (23%), Positives = 117/251 (46%), Gaps = 43/251 (17%) Query: 16 NTHRPRE------YWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKI 69 N RPR YW+ E+ + L ++G G + V++ + V VKI Sbjct: 17 NKIRPRGQRDSSYYWEIEA--------SEVMLSTRIGSGSFGTVYKG---KWHGDVAVKI 65 Query: 70 LK-----PVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQL 124 LK P + + + E+ +L R ++ + + KD + A+V + + L Sbjct: 66 LKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNL----AIVTQWCEGSS---L 118 Query: 125 YQTLTDYDIRFYMYEIL-------KALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWG 177 Y+ L + +F M++++ + +DY H+ I+HRD+K +N+ + HE +++ D+G Sbjct: 119 YKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFL-HEGLTVKIGDFG 177 Query: 178 LAEF---YHPGQEYNVRVASRYFKGPEL--LVDYQMYDYSLDMWSLGCMLASMIFRKEPF 232 LA + Q+ S + PE+ + D + + D++S G +L ++ + P+ Sbjct: 178 LATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPY 237 Query: 233 FHGHDNYDQLV 243 H +N DQ++ Sbjct: 238 SH-INNRDQII 247 >5DBX-A nrPDB Length = 328 Score = 62.0 bits (149), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 54/218 (24%), Positives = 98/218 (44%), Gaps = 25/218 (11%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK----KIKREIKILENLRGG 91 +D Y+L +G G + V A+ E+V +K + K + ++ +EI+ + Sbjct: 10 RDAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMSQC-SH 68 Query: 92 PNIIT--LADIVKDPVSRTPALVFEH---------VNNTDFKQLYQTLTDYDIRFYMYEI 140 PN++T + +VKD + L+ VN + K L + I + E+ Sbjct: 69 PNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKN--GVLEEAIIATILKEV 126 Query: 141 LKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKG- 199 L+ LDY H G +HRD+K N+++ E +++ D+G++ F G + + F G Sbjct: 127 LEGLDYLHRNGQIHRDLKAGNILLG-EDGSVQIADFGVSAFLATGGDVTRNKVRKDFVGT 185 Query: 200 -----PELLVDYQMYDYSLDMWSLGCMLASMIFRKEPF 232 PE++ + YD+ DMWS G + P+ Sbjct: 186 PCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPY 223 >4LG4-A nrPDB Length = 299 Score = 61.6 bits (148), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 51/208 (24%), Positives = 100/208 (48%), Gaps = 13/208 (6%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK--KKIKREIKILENLRGGPN 93 ++ + ++ KLG G Y VF+AI+ + + V +K + PV+ ++I +EI I++ Sbjct: 10 EEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQV-PVESDLQEIIKEISIMQQCDSPYV 68 Query: 94 IITLADIVKDPVSRTPALVFEHVNNTDFKQLY----QTLTDYDIRFYMYEILKALDYCHS 149 + K+ +V E+ + +TL + +I + LK L+Y H Sbjct: 69 VKYYGSYFKN---TDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHF 125 Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLVDYQM 208 M +HR++K N++++ E +L D+G+A + + N + + ++ PE++ + Sbjct: 126 MRKIHRNIKAGNILLNTEGHA-KLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIG- 183 Query: 209 YDYSLDMWSLGCMLASMIFRKEPFFHGH 236 Y+ D+WSLG M K P+ H Sbjct: 184 YNCVADIWSLGITSIEMAEGKPPYADIH 211 >2F57-A nrPDB Length = 317 Score = 61.6 bits (148), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 49/198 (24%), Positives = 85/198 (42%), Gaps = 38/198 (19%) Query: 128 LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGL-AEFYHPGQ 186 + + I +L+AL Y H+ G++HRD+K ++++ + R ++L D+G A+ Sbjct: 138 MNEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGR-IKLSDFGFCAQVSKEVP 196 Query: 187 EYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIA 246 + V + Y+ PE++ Y +D+WSLG M+ MI + P+F+ Sbjct: 197 KRKSLVGTPYWMAPEVISRLP-YGTEVDIWSLGIMVIEMIDGEPPYFN------------ 243 Query: 247 KVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLR 306 E + + L PR D+ H VS FLD +L Sbjct: 244 -----EPPLQAMRRIRDSLPPRVKDL------------------HKVSSVLRGFLDLMLV 280 Query: 307 YDHQSRLTAREAMEHPYF 324 + R TA+E + HP+ Sbjct: 281 REPSQRATAQELLGHPFL 298 >5LOH-A nrPDB Length = 341 Score = 61.6 bits (148), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 78/320 (24%), Positives = 136/320 (42%), Gaps = 60/320 (18%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK--KKKIKREIKILEN---LRGG 91 +++ +V+ + RG + +V+ + + VK++K K + +++ + L Sbjct: 36 EEFSIVKPISRGAFGKVY--LGQKGGKLYAVKVVKKADMINKNMTHQVQAERDALALSKS 93 Query: 92 PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRF---YMYEILKALDYCH 148 P I+ L ++ + LV E++ D K L +D Y+ E+ ALDY H Sbjct: 94 PFIVHLYYSLQS--ANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALALDYLH 151 Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVR--VASRYFKG------P 200 GI+HRD+KP N++I +E ++L D+GL++ ++ N+ + +R F G P Sbjct: 152 RHGIIHRDLKPDNMLISNEGH-IKLTDFGLSKVTL-NRDINMMDILTTRTFCGTPDYLAP 209 Query: 201 ELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDK 260 ELL+ + + ++D W+LG L + PF +D Q V Sbjct: 210 ELLLG-RAHGPAVDWWALGVCLFEFLTGIPPF---NDETPQQV----------------- 248 Query: 261 YNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAME 320 F +IL R W E + +S A ++ LL D R +E Sbjct: 249 --------FQNILKRDI--PW-----PEGEEKLSDNAQSAVEILLTIDDTKRAGMKELKR 293 Query: 321 HPYFYTVVKDQARMGSSSMP 340 HP F V D + +MP Sbjct: 294 HPLFSDV--DWENLQHQTMP 311 >4YHJ-A nrPDB Length = 584 Score = 61.2 bits (147), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 34/98 (34%), Positives = 53/98 (54%), Gaps = 2/98 (2%) Query: 135 FYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVAS 194 FY E+ L+ I++RD+KP N+++D + +R+ D GLA GQ RV + Sbjct: 291 FYAAELCCGLEDLQRERIVYRDLKPENILLD-DRGHIRISDLGLATEIPEGQRVRGRVGT 349 Query: 195 RYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPF 232 + PE+ V+ + Y +S D W LGC++ MI PF Sbjct: 350 VGYMAPEV-VNNEKYTFSPDWWGLGCLIYEMIQGHSPF 386 >3TKU-A nrPDB Length = 433 Score = 60.8 bits (146), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 58/217 (26%), Positives = 105/217 (48%), Gaps = 24/217 (11%) Query: 35 NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVV-------KILKPVKKKKIKREIKILEN 87 +++D+++++ +GRG + EV + + N E++ ++LK + + E +L N Sbjct: 88 HREDFEIIKVIGRGAFGEV-AVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVN 146 Query: 88 LRGGPNIIT-LADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDY---DI-RFYMYEILK 142 G IT L +D LV ++ D L D D+ RFY+ E++ Sbjct: 147 --GDCQWITALHYAFQD--ENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVL 202 Query: 143 ALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWG-LAEFYHPGQ-EYNVRVASRYFKGP 200 A+D H + +HRD+KP NV++D + +RL D+G + G + +V V + + P Sbjct: 203 AIDSIHQLHYVHRDIKPDNVLLD-VNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISP 261 Query: 201 ELLVDYQ----MYDYSLDMWSLGCMLASMIFRKEPFF 233 E+L + Y D WSLG + M++ + PF+ Sbjct: 262 EILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFY 298 >4FR4-A nrPDB Length = 384 Score = 60.8 bits (146), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 47/211 (22%), Positives = 102/211 (48%), Gaps = 19/211 (9%) Query: 35 NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKR--------EIKILE 86 N D ++++R +G+G + +V I N+ K + + K+K ++R E++I++ Sbjct: 13 NFDHFEILRAIGKGSFGKV--CIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQ 70 Query: 87 NLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKA 143 L P ++ L +D +V + + D + Q + ++ ++ E++ A Sbjct: 71 GLEH-PFLVNLWYSFQD--EEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELVMA 127 Query: 144 LDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELL 203 LDY + I+HRD+KP N+++D EH + + D+ +A + ++ + PE+ Sbjct: 128 LDYLQNQRIIHRDMKPDNILLD-EHGHVHITDFNIAAMLPRETQITTMAGTKPYMAPEMF 186 Query: 204 VDYQ--MYDYSLDMWSLGCMLASMIFRKEPF 232 + Y +++D WSLG ++ + P+ Sbjct: 187 SSRKGAGYSFAVDWWSLGVTAYELLRGRRPY 217 >6AO5-A nrPDB Length = 362 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 51/205 (24%), Positives = 98/205 (47%), Gaps = 13/205 (6%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK--KKIKREIKILENLRGGPNIIT 96 + ++ KLG G Y VF+AI+ + + V +K + PV+ ++I +EI I++ + Sbjct: 12 FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQV-PVESDLQEIIKEISIMQQCDSPYVVKY 70 Query: 97 LADIVKDPVSRTPALVFEHVNNTDFKQLY----QTLTDYDIRFYMYEILKALDYCHSMGI 152 K+ +V E+ + +TL + +I + LK L+Y H M Sbjct: 71 YGSYFKN---TDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRK 127 Query: 153 MHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLVDYQMYDY 211 +HR++K N++++ E +L D+G+A + + N + + ++ PE++ + Y+ Sbjct: 128 IHRNIKAGNILLNTEGHA-KLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIG-YNC 185 Query: 212 SLDMWSLGCMLASMIFRKEPFFHGH 236 D+WSLG M K P+ H Sbjct: 186 VADIWSLGITSIEMAEGKPPYADIH 210 >4FZF-B nrPDB Length = 283 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 51/200 (25%), Positives = 94/200 (47%), Gaps = 13/200 (6%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKIL----KPVKKKKIKREIKILENLRGGPNI 94 + + ++G+G + EVF+ I+ + V +KI+ + + I++EI +L Sbjct: 10 FTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSSYVT 69 Query: 95 ITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT--LTDYDIRFYMYEILKALDYCHSMGI 152 +K ++ E++ L + ++ I + EILK LDY HS Sbjct: 70 KYYGSYLK---GSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSEKK 126 Query: 153 MHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ-EYNVRVASRYFKGPELLVDYQMYDY 211 +HRD+K NV++ E ++L +G+A Q + N V + ++ PE ++ YD Sbjct: 127 IHRDIKAANVLL-SEQGDVKLAAFGVAGQLTDTQIKRNTFVGTPFWMAPE-VIQQSAYDS 184 Query: 212 SLDMWSLGCMLASMIFRKEP 231 D+WSLG + A + + EP Sbjct: 185 KADIWSLG-ITAIELAKGEP 203 >2DQ7-X nrPDB Length = 283 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 46/222 (20%), Positives = 102/222 (45%), Gaps = 18/222 (8%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP--VKKKKIKREIKILENLRGGPN 93 ++ QL+++LG G++ EV+ N KV +K LKP + + E +I++ L+ Sbjct: 8 RESLQLIKRLGNGQFGEVWMG-TWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKL 66 Query: 94 IITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRF-----YMYEILKALDYCH 148 + A + ++P+ +V E++N + ++ ++ + Y Sbjct: 67 VQLYAVVSEEPIY----IVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIE 122 Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLVD 205 M +HRD++ N+++ + ++ D+GLA EY R +++ + PE + Sbjct: 123 RMNYIHRDLRSANILVGN-GLICKIADFGLARLIE-DNEYTARQGAKFPIKWTAPEAAL- 179 Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAK 247 Y + D+WS G +L ++ + + G +N + L ++ + Sbjct: 180 YGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVER 221 >3FME-A nrPDB Length = 290 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 61/303 (20%), Positives = 130/303 (42%), Gaps = 54/303 (17%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPV----KKKKIKREIKILENLRGGP 92 DD + + +LGRG Y V + ++ + + + VK ++ ++K++ ++ I P Sbjct: 7 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCP 66 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNTDFKQLY-------QTLTDYDIRFYMYEILKALD 145 +T + + + +T + Y QT+ + + I+KAL+ Sbjct: 67 FTVTFYGAL---FREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALE 123 Query: 146 YCHS-MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELL- 203 + HS + ++HRDVKP NV+I + ++++ D+G++ + ++ + + PE + Sbjct: 124 HLHSKLSVIHRDVKPSNVLI-NALGQVKMCDFGISGYLVDDVAKDIDAGCKPYMAPERIN 182 Query: 204 --VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKY 261 ++ + Y D+WSLG + + + P+ + QL ++ + Sbjct: 183 PELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVE-------------- 228 Query: 262 NIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEH 321 E P+ ++F S E +DF + L+ + + R T E M+H Sbjct: 229 --EPSPQLPA----------DKF---------SAEFVDFTSQCLKKNSKERPTYPELMQH 267 Query: 322 PYF 324 P+F Sbjct: 268 PFF 270 >4E93-A nrPDB Length = 377 Score = 58.9 bits (141), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 55/201 (27%), Positives = 87/201 (43%), Gaps = 20/201 (9%) Query: 35 NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVK----ILKPVKKKKIKREIKILENLRG 90 N +D L ++GRG + EVF +N V VK L P K K +E +IL+ Sbjct: 112 NHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQY-S 170 Query: 91 GPNIITLADIV--KDPVSRTPALVFEHVNNTDFKQLYQT----LTDYDIRFYMYEILKAL 144 PNI+ L + K P+ +V E V DF +T L + + + + Sbjct: 171 HPNIVRLIGVCTQKQPIY----IVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGM 226 Query: 145 DYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPG---QEYNVRVASRYFKGPE 201 +Y S +HRD+ N ++ E L++ D+G++ G +R + PE Sbjct: 227 EYLESKCCIHRDLAARNCLVT-EKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPE 285 Query: 202 LLVDYQMYDYSLDMWSLGCML 222 L +Y Y D+WS G +L Sbjct: 286 AL-NYGRYSSESDVWSFGILL 305 >3ALO-A nrPDB Length = 327 Score = 58.9 bits (141), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 66/318 (20%), Positives = 130/318 (40%), Gaps = 54/318 (16%) Query: 20 PREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVK-ILKPVKKKKI 78 P ++WD+ + +D + + ++GRG Y V + ++ + + + VK I V +K+ Sbjct: 13 PEQHWDFTA--------EDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQ 64 Query: 79 KREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMY 138 K+ + L+ + + + + + +T F + Y+ + Sbjct: 65 KQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPE 124 Query: 139 EIL--------KALDYC-HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYN 189 EIL KAL++ ++ I+HRD+KP N+++D ++L D+G++ Sbjct: 125 EILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSG-NIKLCDFGISGQLVDSIAKT 183 Query: 190 VRVASRYFKGPELL---VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIA 246 R + PE + Q YD D+WSLG L + + P+ + +DQL ++ Sbjct: 184 RDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVV 243 Query: 247 KVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLR 306 K DP + +SE + SP ++F++ L Sbjct: 244 KG-----------------DP--------------PQLSNSEEREF-SPSFINFVNLCLT 271 Query: 307 YDHQSRLTAREAMEHPYF 324 D R +E ++HP+ Sbjct: 272 KDESKRPKYKELLKHPFI 289 >4M66-A nrPDB Length = 325 Score = 58.9 bits (141), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 48/168 (28%), Positives = 82/168 (48%), Gaps = 13/168 (7%) Query: 22 EYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKRE 81 + W + V ++++ + + +G+G + VF A + T N V VKI V KKI E Sbjct: 5 KLWPTGASAVPLVSREELKKLEFVGKGGFGVVFRAHHRTWNHDVAVKI---VNSKKISWE 61 Query: 82 IKILENLRGGPNIITLADIVKD---PVSRTPALVFEHVNNTDFKQLYQTLTDYD---IRF 135 +K + NLR N++ L + +D ALV + N L Q + Sbjct: 62 VKAMVNLRN-ENVLLLLGVTEDLQWDFVSGQALVTRFMENGSLAGLLQPEAPRPWPLLCR 120 Query: 136 YMYEILKALDYCHSMG--IMHRDVKPHNVMIDHEHRKLRLIDWGLAEF 181 + E++ + Y HS+ ++HRD+KP N+++D E +L D+GL+ F Sbjct: 121 LLQEVVLGMCYLHSLDPPLLHRDLKPSNILLDPELHA-KLADFGLSTF 167 >6HV0-A nrPDB Length = 416 Score = 58.5 bits (140), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 66/286 (23%), Positives = 118/286 (41%), Gaps = 57/286 (19%) Query: 61 NNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKD------PVSRTPALVFE 114 +N V VK + P RE+++L PN+I KD + A + E Sbjct: 31 DNRDVAVKRILPECFSFADREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQE 90 Query: 115 HVNNTDFKQL-YQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMID----HEHR 169 +V DF L + +T + + L + HS+ I+HRD+KPHN++I H Sbjct: 91 YVEQKDFAHLGLEPIT------LLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKI 144 Query: 170 KLRLIDWGLAEFYHPGQEYNVRVA----SRYFKGPELLVD--YQMYDYSLDMWSLGCMLA 223 K + D+GL + G+ R + + + PE+L + + Y++D++S GC+ Sbjct: 145 KAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFY 204 Query: 224 SMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWER 283 +I H L R A +L D + E D++ R Sbjct: 205 YVISEG-----SHPFGKSLQRQANILLGACSLDCLHPEKHE------DVIAR-------- 245 Query: 284 FVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 329 + ++K++ D Q R +A+ ++HP+F+++ K Sbjct: 246 ---------------ELIEKMIAMDPQKRPSAKHVLKHPFFWSLEK 276 >4PL5-B nrPDB Length = 435 Score = 58.5 bits (140), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 67/287 (23%), Positives = 126/287 (43%), Gaps = 59/287 (20%) Query: 61 NNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKD------PVSRTPALVFE 114 +N V VK + P RE+++L PN+I KD + A + E Sbjct: 50 DNRDVAVKRILPECFSFADREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQE 109 Query: 115 HVNNTDFKQL-YQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMID----HEHR 169 +V DF L + +T +++ L + HS+ I+HRD+KPHN+++ H Sbjct: 110 YVEQKDFAHLGLEPIT------LLHQTTSGLAHLHSLNIVHRDLKPHNILLSMPNAHGRI 163 Query: 170 KLRLIDWGLAEFYHPGQEYNVRVA----SRYFKGPELLVDYQMYD--YSLDMWSLGCMLA 223 K + D+GL + G+ R + + + PE+L + + Y++D++S GC+ Sbjct: 164 KAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKDNPTYTVDIFSAGCVFY 223 Query: 224 SMIFRKEPFFHGHDNYDQLVRIAKV-LGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWE 282 +I E + H L R A + LG +L D ++ + + D++ R Sbjct: 224 YVI--SEGY---HPFGKSLQRQANILLGACNL----DCFHSD---KHEDVIAR------- 264 Query: 283 RFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 329 + ++K++ D Q R +A+ ++HP+F+++ K Sbjct: 265 ----------------ELIEKMIAMDPQQRPSAKHVLKHPFFWSLEK 295 >4CSV-A nrPDB Length = 275 Score = 58.5 bits (140), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 51/220 (23%), Positives = 102/220 (46%), Gaps = 15/220 (6%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK--PVKKKKIKREIKILENLRGGPN 93 + + L RKLG G++ EV+E N +V VK LK + ++ +E +I++ L+ PN Sbjct: 10 RSEITLERKLGSGQFGEVYEGKWRNYNIEVAVKTLKEGTMSVEEFLQEAQIMKKLK-HPN 68 Query: 94 IITLADIV-KDPVSRTPALVFEHVNNTDFKQLYQ--TLTDYDIRFYMYEILKALDYCHSM 150 ++ L + K+P H + D+ + + T+ + ++ + Y S Sbjct: 69 LVQLYGVCTKEPPIYIITEYMSHGSLLDYLRDCEGHTVNAQALLDMAAQVASGMAYLESQ 128 Query: 151 GIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLVDYQ 207 +HRD+ N ++ E+ +++ D+GLA + EY R +++ + PE + Y Sbjct: 129 NFIHRDLAARNCLVG-ENNVVKVADFGLARLINE-DEYTARAGAKFPIKWTAPE-AISYN 185 Query: 208 MYDYSLDMWSLGCMLASMIFRKE---PFFHGHDNYDQLVR 244 + D+W+ G +L + + P G + +Q+ R Sbjct: 186 RFSIKSDVWAFGILLWEIFTYGQVPYPGMSGSEVIEQVER 225 >2PZI-A nrPDB Length = 681 Score = 58.2 bits (139), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 53/184 (28%), Positives = 89/184 (48%), Gaps = 19/184 (10%) Query: 92 PNIITLADIVK------DPVSRTPALVFEHVNNTDFKQLY-QTLTDYDIRFYMYEILKAL 144 P+I+ + + V+ DPV +V E+V K+ Q L + Y+ EIL AL Sbjct: 139 PSIVQIFNFVEHTDRHGDPVGY---IVMEYVGGQSLKRSKGQKLPVAEAIAYLLEILPAL 195 Query: 145 DYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLV 204 Y HS+G+++ D+KP N+M+ E +L+LID G + + + F+ PE++ Sbjct: 196 SYLHSIGLVYNDLKPENIMLTEE--QLKLIDLGAVSRIN---SFGYLYGTPGFQAPEIV- 249 Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIE 264 + D++++G LA++ P +G D L VL T D Y + + I+ Sbjct: 250 -RTGPTVATDIYTVGRTLAALTL-DLPTRNGR-YVDGLPEDDPVLKTYDSYGRLLRRAID 306 Query: 265 LDPR 268 DPR Sbjct: 307 PDPR 310 >4HVI-A nrPDB Length = 314 Score = 58.2 bits (139), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 49/196 (25%), Positives = 96/196 (48%), Gaps = 18/196 (9%) Query: 42 VRKLGRGKYSEV----FEAINITNNEKVVVKILK---PVKKKKIKREIKILENLRGGPNI 94 + +LG+G + V ++ + V VK L+ P +++ +REI+IL+ L I Sbjct: 15 ISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSD-FI 73 Query: 95 ITLADIVKDPVSRTPALVFEHVNNT---DFKQLYQTLTDYD-IRFYMYEILKALDYCHSM 150 + + P ++ LV E++ + DF Q ++ D + Y +I K ++Y S Sbjct: 74 VKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSR 133 Query: 151 GIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNV----RVASRYFKGPELLVDY 206 +HRD+ N++++ E +++ D+GLA+ ++Y V + ++ PE L D Sbjct: 134 RCVHRDLAARNILVESEAH-VKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSD- 191 Query: 207 QMYDYSLDMWSLGCML 222 ++ D+WS G +L Sbjct: 192 NIFSRQSDVWSFGVVL 207 >4Y12-A nrPDB Length = 375 Score = 58.2 bits (139), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 53/184 (28%), Positives = 89/184 (48%), Gaps = 19/184 (10%) Query: 92 PNIITLADIVK------DPVSRTPALVFEHVNNTDFKQLY-QTLTDYDIRFYMYEILKAL 144 P+I+ + + V+ DPV +V E+V K+ Q L + Y+ EIL AL Sbjct: 178 PSIVQIFNFVEHTDRHGDPVGY---IVMEYVGGQSLKRSKGQKLPVAEAIAYLLEILPAL 234 Query: 145 DYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLV 204 Y HS+G+++ D+KP N+M+ E +L+LID G + + + F+ PE++ Sbjct: 235 SYLHSIGLVYNDLKPENIMLTEE--QLKLIDLGAVSRIN---SFGYLYGTPGFQAPEIVR 289 Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIE 264 + D++++G LA++ P +G D L VL T D Y + + I+ Sbjct: 290 TGPT--VATDIYTVGRTLAALTL-DLPTRNGR-YVDGLPEDDPVLKTYDSYGRLLRRAID 345 Query: 265 LDPR 268 DPR Sbjct: 346 PDPR 349 >6GVJ-A nrPDB Length = 429 Score = 57.8 bits (138), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 74/314 (23%), Positives = 125/314 (39%), Gaps = 77/314 (24%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKI--------KREIKILENLRG 90 Y +++++G G S+VF+ +N EK + +K V ++ + EI L L+ Sbjct: 146 YSILKQIGSGGSSKVFQVLN----EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQ 201 Query: 91 -GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ---TLTDYDIRFYMYEILKALDY 146 II L D + + +V E N D + ++ ++ + Y +L+A+ Sbjct: 202 HSDKIIRLYDY--EITDQYIYMVME-CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHT 258 Query: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVR---VASRYFKGPELL 203 H GI+H D+KP N +I L+LID+G+A P V+ V + + PE + Sbjct: 259 IHQHGIVHSDLKPANFLI--VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAI 316 Query: 204 VDYQ----------MYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTED 253 D D+WSLGC+L M + K PF + Sbjct: 317 KDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF-------------------QQ 357 Query: 254 LYDYIDKYNIELDP----RFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDH 309 + + I K + +DP F DI + + D L L+ D Sbjct: 358 IINQISKLHAIIDPNHEIEFPDIPEK--------------------DLQDVLKCCLKRDP 397 Query: 310 QSRLTAREAMEHPY 323 + R++ E + HPY Sbjct: 398 KQRISIPELLAHPY 411 >5HI2-A nrPDB Length = 283 Score = 57.8 bits (138), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 49/215 (22%), Positives = 101/215 (46%), Gaps = 24/215 (11%) Query: 43 RKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVK 102 +++G G + V++ + V VK+L P + + K E+ +L R NI+ Sbjct: 26 QRIGSGSFGTVYKG---KWHGDVAVKMLTPQQLQAFKNEVGVLRKTRH-VNILLFMGYST 81 Query: 103 DPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEIL-------KALDYCHSMGIMHR 155 P A+V + + LY L + +F M +++ + +DY H+ I+HR Sbjct: 82 KP---QLAIVTQWCEGSS---LYHHLHASETKFEMKKLIDIARQTARGMDYLHAKSIIHR 135 Query: 156 DVKPHNVMIDHEHRKLRLIDWGLAEF---YHPGQEYNVRVASRYFKGPEL--LVDYQMYD 210 D+K +N+ + HE +++ D+GLA + ++ S + PE+ + D Y Sbjct: 136 DLKSNNIFL-HEDNTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDSNPYS 194 Query: 211 YSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRI 245 + D+++ G +L ++ + P + +N DQ++ + Sbjct: 195 FQSDVYAFGIVLYELMTGQLP-YSNINNRDQIIEM 228 >5H2U-A nrPDB Length = 267 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 56/225 (24%), Positives = 109/225 (48%), Gaps = 27/225 (12%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP---VKKKKIKREIKILENLRGGP 92 ++++ L RKLG G + EVFE + + +V +K++ + ++ ++ EI+ ++ LR Sbjct: 5 REEFTLCRKLGSGYFGEVFEGL-WKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLR-HK 62 Query: 93 NIITLADIVK--DPVSRTPAL-----VFEHVNNTDFKQL-YQTLTDYDIRFYMYEILKAL 144 +I+ L +V DPV L + E + ++D K L L D +++ + + Sbjct: 63 HILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLD-----IAWQVAEGM 117 Query: 145 DYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA----EFYHPGQEYNVRVASRYFKGP 200 Y S +HRD+ N+++ E+ ++ D+GLA E + ++N+ + P Sbjct: 118 CYLESQNYIHRDLAARNILVG-ENTLCKVGDFGLARLIKEDVYLSHDHNIPYK---WTAP 173 Query: 201 ELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRI 245 E L Y D+WS G +L M R + + G N++ +R+ Sbjct: 174 EAL-SRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRV 217 >4APC-A nrPDB Length = 350 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 46/214 (21%), Positives = 104/214 (48%), Gaps = 16/214 (7%) Query: 33 WGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVK-----ILKPVKKKKIKREIKILEN 87 + + + Y ++K+G G + + + + + V+K + ++++ +RE+ +L N Sbjct: 20 FQSMEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLAN 79 Query: 88 LRGGPNIITLADIVKDPVSRTPALVFEHVNNTD-FKQLYQT----LTDYDIRFYMYEILK 142 ++ PNI+ + ++ + + +V ++ D FK++ + I + +I Sbjct: 80 MKH-PNIVQYRESFEE--NGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICL 136 Query: 143 ALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEY-NVRVASRYFKGPE 201 AL + H I+HRD+K N+ + + ++L D+G+A + E + + Y+ PE Sbjct: 137 ALKHVHDRKILHRDIKSQNIFLTKDG-TVQLGDFGIARVLNSTVELARACIGTPYYLSPE 195 Query: 202 LLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHG 235 + + + Y+ D+W+LGC+L + K F G Sbjct: 196 -ICENKPYNNKSDIWALGCVLYELCTLKHAFEAG 228 >5O2B-A nrPDB Length = 285 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 64/296 (21%), Positives = 125/296 (42%), Gaps = 57/296 (19%) Query: 44 KLGRGKYSEVFEAINITNNEKVVV-----KILKPVKKKKIKREIKILENLRGGPNIITLA 98 +LGRG + V++ ++ +V + L ++++ K E ++L+ L+ PNI+ Sbjct: 23 ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQH-PNIVRFY 81 Query: 99 D----IVKDPVSRTPALVFEHVNNTDFK---QLYQTLTDYDIRFYMYEILKALDYCHSMG 151 D I+K + LV E + + K + ++ + +R + +ILK L + H+ Sbjct: 82 DSWESILKG--KKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRT 139 Query: 152 --IMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMY 209 I+HRD+K N+ I +++ D GLA +V + + F PE+ ++ Y Sbjct: 140 PPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSV-IGTPEFMAPEMYEEH--Y 196 Query: 210 DYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDP-R 268 D S+D+++ G + M + P+ N Q+ R K + P Sbjct: 197 DESVDVYAFGMCMLEMATSEYPYSECQ-NAAQIYR---------------KVTSGIKPAS 240 Query: 269 FNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 FN + PE + ++ +R + RL+ R+ + H +F Sbjct: 241 FNKV--------------------TDPEVKEIIEGCIRQNKSERLSIRDLLNHAFF 276 >4IDT-A nrPDB Length = 356 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 60/228 (26%), Positives = 92/228 (40%), Gaps = 32/228 (14%) Query: 25 DYE-SHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIK 83 DYE V W +QL +LGRG + EV + + VK K++ E+ Sbjct: 66 DYEYREEVHWAT---HQL--RLGRGSFGEVHRMEDKQTGFQCAVK--------KVRLEVF 112 Query: 84 ILENLRG-----GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ---TLTDYDIRF 135 E L P I+ L V++ + E + QL + L + + Sbjct: 113 RAEELMACAGLTSPRIVPLYGAVRE--GPWVNIFMELLEGGSLGQLVKEQGCLPEDRALY 170 Query: 136 YMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASR 195 Y+ + L+ L+Y HS I+H DVK NV++ + L D+G A P + Sbjct: 171 YLGQALEGLEYLHSRRILHGDVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKDLLTGD 230 Query: 196 YFKGPEL-----LVDYQMYDYSLDMWSLGCMLASMIFRKEP---FFHG 235 Y G E +V + D +D+WS CM+ M+ P FF G Sbjct: 231 YIPGTETHMAPEVVLGRSCDAKVDVWSSCCMMLHMLNGCHPWTQFFRG 278 >5O2C-A nrPDB Length = 380 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 64/296 (21%), Positives = 125/296 (42%), Gaps = 57/296 (19%) Query: 44 KLGRGKYSEVFEAINITNNEKVVV-----KILKPVKKKKIKREIKILENLRGGPNIITLA 98 +LGRG + V++ ++ +V + L ++++ K E ++L+ L+ PNI+ Sbjct: 32 ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQH-PNIVRFY 90 Query: 99 D----IVKDPVSRTPALVFEHVNNTDFK---QLYQTLTDYDIRFYMYEILKALDYCHSMG 151 D I+K + LV E + + K + ++ + +R + +ILK L + H+ Sbjct: 91 DSWESILKG--KKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRT 148 Query: 152 --IMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMY 209 I+HRD+K N+ I +++ D GLA +V + + F PE+ ++ Y Sbjct: 149 PPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSV-IGTPEFMAPEMYEEH--Y 205 Query: 210 DYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDP-R 268 D S+D+++ G + M + P+ N Q+ R K + P Sbjct: 206 DESVDVYAFGMCMLEMATSEYPYSECQ-NAAQIYR---------------KVTSGIKPAS 249 Query: 269 FNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 FN + PE + ++ +R + RL+ R+ + H +F Sbjct: 250 FNKV--------------------TDPEVKEIIEGCIRQNKSERLSIRDLLNHAFF 285 >4H1J-A nrPDB Length = 293 Score = 57.0 bits (136), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 50/209 (23%), Positives = 98/209 (46%), Gaps = 14/209 (6%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK-------KKIKREIKILENL 88 ++D L R LG G + EV+E + + + + +K KK +K E I++NL Sbjct: 23 REDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNL 82 Query: 89 RGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ-TLTDYDIRFYMYEILKALDYC 147 P+I+ L I+++ + ++ + + + + +L + Y +I KA+ Y Sbjct: 83 -DHPHIVKLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYL 141 Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFK--GPELLVD 205 S+ +HRD+ N+++ ++L D+GL+ + Y V K PE ++ Sbjct: 142 ESINCVHRDIAVRNILVASPE-CVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPE-SIN 199 Query: 206 YQMYDYSLDMWSLG-CMLASMIFRKEPFF 233 ++ + + D+W CM + F K+PFF Sbjct: 200 FRRFTTASDVWMFAVCMWEILSFGKQPFF 228 >2VD5-A nrPDB Length = 412 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 58/218 (26%), Positives = 94/218 (43%), Gaps = 24/218 (11%) Query: 35 NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKI------LKPVKKKKIKREIKILENL 88 +DD+++++ +GRG +SEV + +KI LK + + E +L N Sbjct: 59 QRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVN- 117 Query: 89 RGGPNIIT-LADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYD----IRFYMYEILKA 143 G IT L +D LV E+ D L + RFY+ EI+ A Sbjct: 118 -GDRRWITQLHFAFQD--ENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMA 174 Query: 144 LDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWG-LAEFYHPGQEYN-VRVASRYFKGPE 201 +D H +G +HRD+KP N+++D +RL D+G + G + V V + + PE Sbjct: 175 IDSVHRLGYVHRDIKPDNILLDR-CGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPE 233 Query: 202 LLVDYQMYDY------SLDMWSLGCMLASMIFRKEPFF 233 +L D W+LG M + + PF+ Sbjct: 234 ILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFY 271 >3HMP-A nrPDB Length = 342 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 58/219 (26%), Positives = 97/219 (44%), Gaps = 34/219 (15%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKI--------KREIKILENLRG 90 Y +++++G G S+VF+ +N EK + +K V ++ + EI L L+ Sbjct: 58 YSILKQIGSGGSSKVFQVLN----EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQ 113 Query: 91 -GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ---TLTDYDIRFYMYEILKALDY 146 II L D + + +V E N D + ++ ++ + Y +L+A+ Sbjct: 114 HSDKIIRLYDY--EITDQYIYMVME-CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHT 170 Query: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVR---VASRYFKGPELL 203 H GI+H D+KP N +I L+LID+G+A P V+ V + + PE + Sbjct: 171 IHQHGIVHSDLKPANFLI--VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAI 228 Query: 204 VDYQ----------MYDYSLDMWSLGCMLASMIFRKEPF 232 D D+WSLGC+L M + K PF Sbjct: 229 KDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF 267 >2ZMD-A nrPDB Length = 390 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 58/219 (26%), Positives = 97/219 (44%), Gaps = 34/219 (15%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKI--------KREIKILENLRG 90 Y +++++G G S+VF+ +N EK + +K V ++ + EI L L+ Sbjct: 58 YSILKQIGSGGSSKVFQVLN----EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQ 113 Query: 91 -GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ---TLTDYDIRFYMYEILKALDY 146 II L D + + +V E N D + ++ ++ + Y +L+A+ Sbjct: 114 HSDKIIRLYDY--EITDQYIYMVME-CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHT 170 Query: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVR---VASRYFKGPELL 203 H GI+H D+KP N +I L+LID+G+A P V+ V + + PE + Sbjct: 171 IHQHGIVHSDLKPANFLI--VDGMLKLIDFGIANQMQPDTTSVVKDSQVGAVNYMPPEAI 228 Query: 204 VDYQ----------MYDYSLDMWSLGCMLASMIFRKEPF 232 D D+WSLGC+L M + K PF Sbjct: 229 KDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF 267 >3SV0-A nrPDB Length = 483 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 42/152 (27%), Positives = 78/152 (51%), Gaps = 8/152 (5%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK--KIKREIKILENLRGGPNI 94 + ++L RK+G G + E++ NI NE+V +K L+ VK K ++ E KI L+GG I Sbjct: 7 NKFRLGRKIGSGSFGEIYLGTNIQTNEEVAIK-LENVKTKHPQLLYESKIYRILQGGTGI 65 Query: 95 --ITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGI 152 + + D L+ + + F + L+ + +++ +++ HS Sbjct: 66 PNVRWFGVEGDYNVLVMDLLGPSLEDL-FNFCSRKLSLKTVLMLADQMINRVEFVHSKSF 124 Query: 153 MHRDVKPHNVMIDHEHR--KLRLIDWGLAEFY 182 +HRD+KP N ++ R ++ +ID+GLA+ Y Sbjct: 125 LHRDIKPDNFLMGLGRRANQVYIIDFGLAKKY 156 >5X5O-A nrPDB Length = 310 Score = 55.8 bits (133), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 53/207 (25%), Positives = 105/207 (50%), Gaps = 25/207 (12%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIIT 96 DD Q G G + V+ A I+ +++V VK K KI++E +IL L NII Sbjct: 15 DDLQFFENCGGGSFGSVYRAKWISQDKEVAVK-----KLLKIEKEAEILSVL-SHRNIIQ 68 Query: 97 LADIVKDP-----VSRTPAL--VFEHVNNTDFKQLYQTLTDYD-IRFYMYEILKALDYCH 148 ++ +P V+ +L +++++N+ +++ D D I + ++ K + Y H Sbjct: 69 FYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEM-----DMDHIMTWATDVAKGMHYLH 123 Query: 149 S---MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVD 205 + ++HRD+K NV+I + L++ D+G + F++ ++ V + + PE++ Sbjct: 124 MEAPVKVIHRDLKSRNVVIAADGV-LKICDFGASRFHNHTTHMSL-VGTFPWMAPEVIQS 181 Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPF 232 + + + D +S G +L M+ R+ PF Sbjct: 182 LPVSE-TCDTYSYGVVLWEMLTREVPF 207 >4PWN-A nrPDB Length = 274 Score = 55.8 bits (133), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 47/192 (24%), Positives = 92/192 (47%), Gaps = 16/192 (8%) Query: 44 KLGRGKYSEVFEAINITNNEKVVV-----KILKPVKKKKIKREIKILENLRGGPNIITLA 98 ++GRG + V++ ++ +V + L ++++ K E ++L+ L+ PNI+ Sbjct: 17 EIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQH-PNIVRFY 75 Query: 99 DIVKDPVS--RTPALVFEHVNNTDFK---QLYQTLTDYDIRFYMYEILKALDYCHSMG-- 151 D + V + LV E + + K + ++ + +R + +ILK L + H+ Sbjct: 76 DSWESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKGLQFLHTRTPP 135 Query: 152 IMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDY 211 I+HRD+K N+ I +++ D GLA + + F PE+ + YD Sbjct: 136 IIHRDLKCDNIFITGPTGSVKIGDLGLATLEKRASFAKSVIGTPEFMAPEMY--EEKYDE 193 Query: 212 SLDMWSLG-CML 222 S+D+++ G CML Sbjct: 194 SVDVYAFGMCML 205 >4XEY-B nrPDB Length = 408 Score = 55.8 bits (133), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 44/195 (22%), Positives = 92/195 (47%), Gaps = 12/195 (6%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK--PVKKKKIKREIKILENLRGGPN 93 + D + KLG G+Y EV+E + + V VK LK ++ ++ +E +++ ++ PN Sbjct: 124 RTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIK-HPN 182 Query: 94 IITLADIV-KDPVSRTPALVFEHVNNTDF-KQLYQTLTDYDIRFYM-YEILKALDYCHSM 150 ++ L + ++P + N D+ ++ + + + YM +I A++Y Sbjct: 183 LVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKK 242 Query: 151 GIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLVDYQ 207 +HRD+ N ++ H +++ D+GL+ G Y +++ + PE L Y Sbjct: 243 NFIHRDLAARNCLVGENHL-VKVADFGLSRLM-TGDTYTAHAGAKFPIKWTAPESLA-YN 299 Query: 208 MYDYSLDMWSLGCML 222 + D+W+ G +L Sbjct: 300 KFSIKSDVWAFGVLL 314 >5HIE-A nrPDB Length = 302 Score = 55.8 bits (133), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 49/213 (23%), Positives = 100/213 (46%), Gaps = 24/213 (11%) Query: 43 RKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVK 102 +++G G + V++ + V VK+L P + + K E+ +L R NI+ Sbjct: 42 QRIGSGSFGTVYKG---KWHGDVAVKMLTPQQLQAFKNEVGVLRKTRH-VNILLFMGYST 97 Query: 103 DPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEIL-------KALDYCHSMGIMHR 155 P A+V + + LY L + +F M +++ + +DY H+ I+HR Sbjct: 98 KP---QLAIVTQWCEGSS---LYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHR 151 Query: 156 DVKPHNVMIDHEHRKLRLIDWGLAEF---YHPGQEYNVRVASRYFKGPEL--LVDYQMYD 210 D+K +N+ + HE +++ D+GLA + ++ S + PE+ + D Y Sbjct: 152 DLKSNNIFL-HEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYS 210 Query: 211 YSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLV 243 + D+++ G +L ++ + P + +N DQ++ Sbjct: 211 FQSDVYAFGIVLYELMTGQLP-YSNINNRDQII 242 >6BXI-A nrPDB Length = 333 Score = 55.5 bits (132), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 60/242 (24%), Positives = 105/242 (43%), Gaps = 52/242 (21%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIIT 96 +D++ ++ +GRG + EV +KIL+ K +++E + ++R +I+ Sbjct: 6 EDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILR--KADMLEKEQ--VGHIRAERDILV 61 Query: 97 LAD---IVKDPVSRTPAL----VFEHVNNTDFKQLYQ---TLTDYDIRFYMYEILKALDY 146 AD +VK S L + E + D L TLT+ + +FY+ E + A+D Sbjct: 62 EADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDS 121 Query: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA---------EFYH----------PGQE 187 H +G +HRD+KP N+++D + ++L D+GL EFY Q Sbjct: 122 IHQLGFIHRDIKPDNLLLDSKGH-VKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQN 180 Query: 188 YNVRVASRYFK-----------------GPELLVDYQMYDYSLDMWSLGCMLASMIFRKE 230 N + + +K PE+ + Y+ D WSLG ++ M+ Sbjct: 181 MNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTG-YNKLCDWWSLGVIMYEMLIGYP 239 Query: 231 PF 232 PF Sbjct: 240 PF 241 >5AP3-A nrPDB Length = 313 Score = 55.5 bits (132), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 58/219 (26%), Positives = 98/219 (44%), Gaps = 34/219 (15%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKI--------KREIKILENLRG 90 Y +++++G G S+VF+ +N EK + +K V ++ + EI L L+ Sbjct: 30 YSILKQIGSGGSSKVFQVLN----EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQ 85 Query: 91 -GPNIITLADIVKDPVSRTPALVFEHVNNTDFK---QLYQTLTDYDIRFYMYEILKALDY 146 II L D + + +V E N D + +++ ++ + Y +L+A+ Sbjct: 86 HSDKIIRLYDY--EITDQYIYMVME-CGNIDLNGWLKKKKSIDPWERKSYWKNMLEAVHT 142 Query: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVR---VASRYFKGPELL 203 H GI+H D+KP N +I L+LID+G+A P V+ V + + PE + Sbjct: 143 IHQHGIVHSDLKPANFLI--VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAI 200 Query: 204 VDYQ----------MYDYSLDMWSLGCMLASMIFRKEPF 232 D D+WSLGC+L M + K PF Sbjct: 201 KDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF 239 >2H8H-A nrPDB Length = 535 Score = 55.5 bits (132), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 47/222 (21%), Positives = 100/222 (45%), Gaps = 18/222 (8%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP--VKKKKIKREIKILENLRGGPN 93 ++ +L KLG+G + EV+ +V +K LKP + + +E ++++ LR Sbjct: 266 RESLRLEVKLGQGCFGEVWMG-TWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKL 324 Query: 94 IITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRF-----YMYEILKALDYCH 148 + A + ++P+ +V E+++ + T +R +I + Y Sbjct: 325 VQLYAVVSEEPI----YIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVE 380 Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLVD 205 M +HRD++ N+++ E+ ++ D+GLA EY R +++ + PE + Sbjct: 381 RMNYVHRDLRAANILVG-ENLVCKVADFGLARLIE-DNEYTARQGAKFPIKWTAPEAAL- 437 Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAK 247 Y + D+WS G +L + + + G N + L ++ + Sbjct: 438 YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER 479 >6F3F-A nrPDB Length = 455 Score = 55.5 bits (132), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 48/222 (21%), Positives = 100/222 (45%), Gaps = 18/222 (8%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP--VKKKKIKREIKILENLRGGPN 93 ++ +L KLG+G + EV+ +V +K LKP + + +E ++++ LR Sbjct: 186 RESLRLEVKLGQGCFGEVWMG-TWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKL 244 Query: 94 IITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRF-----YMYEILKALDYCH 148 + A + ++P+ +V E++N + T +R +I + Y Sbjct: 245 VQLYAVVSEEPI----YIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVE 300 Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLVD 205 M +HRD++ N+++ E+ ++ D+GLA EY R +++ + PE + Sbjct: 301 RMNYVHRDLRAANILVG-ENLVCKVADFGLARLIE-DNEYTARQGAKFPIKWTAPEAAL- 357 Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAK 247 Y + D+WS G +L + + + G N + L ++ + Sbjct: 358 YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER 399 >4G3E-A nrPDB Length = 352 Score = 54.7 bits (130), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 48/202 (23%), Positives = 84/202 (41%), Gaps = 23/202 (11%) Query: 44 KLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRG-----GPNIITLA 98 ++GRG + EV + + VK K++ E+ +E L P I+ L Sbjct: 81 RVGRGSFGEVHRMKDKQTGFQCAVK--------KVRLEVFRVEELVACAGLSSPRIVPLY 132 Query: 99 DIVKDPVSRTPALVFEHVNNTDFKQLYQ---TLTDYDIRFYMYEILKALDYCHSMGIMHR 155 V++ + E + QL + L + +Y+ + L+ L+Y H+ I+H Sbjct: 133 GAVRE--GPWVNIFMELLEGGSLGQLIKQMGCLPEDRALYYLGQALEGLEYLHTRRILHG 190 Query: 156 DVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPEL-----LVDYQMYD 210 DVK NV++ + + L D+G A P + Y G E +V + D Sbjct: 191 DVKADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAPEVVMGKPCD 250 Query: 211 YSLDMWSLGCMLASMIFRKEPF 232 +D+WS CM+ M+ P+ Sbjct: 251 AKVDIWSSCCMMLHMLNGCHPW 272 >2W1I-A nrPDB Length = 326 Score = 54.7 bits (130), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 47/202 (23%), Positives = 104/202 (51%), Gaps = 18/202 (8%) Query: 40 QLVRKLGRGKYSEV----FEAINITNNEKVVVKILKPVKKKKIK---REIKILENLRGGP 92 + +++LG+G + V ++ + E V VK L+ ++ ++ REI+IL++L+ Sbjct: 44 KFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHD- 102 Query: 93 NIITLADIVKDPVSRTPALVFEHV---NNTDFKQLYQTLTDY-DIRFYMYEILKALDYCH 148 NI+ + R L+ E++ + D+ Q ++ D+ + Y +I K ++Y Sbjct: 103 NIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLG 162 Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE-YNVRVASR---YFKGPELLV 204 + +HRD+ N+++++E+R +++ D+GL + +E Y V+ ++ PE L Sbjct: 163 TKRYIHRDLATRNILVENENR-VKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLT 221 Query: 205 DYQMYDYSLDMWSLGCMLASMI 226 + + + + D+WS G +L + Sbjct: 222 ESK-FSVASDVWSFGVVLYELF 242 >3IO7-A nrPDB Length = 313 Score = 54.7 bits (130), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 49/214 (22%), Positives = 108/214 (50%), Gaps = 18/214 (8%) Query: 28 SHVVEWGNQDDYQLVRKLGRGKYSEV----FEAINITNNEKVVVKILKPVKKKKIK---R 80 SH + + + +++LG+G + V ++ + E V VK L+ ++ ++ R Sbjct: 19 SHNMTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFER 78 Query: 81 EIKILENLRGGPNIITLADIVKDPVSRTPALVFEHV---NNTDFKQLYQTLTDY-DIRFY 136 EI+IL++L+ NI+ + R L+ E++ + D+ Q ++ D+ + Y Sbjct: 79 EIEILKSLQH-DNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQY 137 Query: 137 MYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE-YNVRVASR 195 +I K ++Y + +HRD+ N+++++E+R +++ D+GL + +E Y V+ Sbjct: 138 TSQICKGMEYLGTKRYIHRDLATRNILVENENR-VKIGDFGLTKVLPQDKEYYKVKEPGE 196 Query: 196 ---YFKGPELLVDYQMYDYSLDMWSLGCMLASMI 226 ++ PE L + + + + D+WS G +L + Sbjct: 197 SPIFWYAPESLTESK-FSVASDVWSFGVVLYELF 229 >3CJF-A nrPDB Length = 309 Score = 54.7 bits (130), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 54/213 (25%), Positives = 98/213 (46%), Gaps = 28/213 (13%) Query: 36 QDDYQLVRKLGRGKYSEVFEA----INITNNEKVV-VKILKP----VKKKKIKREIKILE 86 +D L + LGRG + +V EA I+ T + V VK+LK + + + E+KIL Sbjct: 26 RDRLNLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILI 85 Query: 87 NLRGGPNIITLADIVKDPVSRTPALV-FEHVNNTD------------FKQLYQT-LTDYD 132 ++ N++ L P +V F N +K LY+ LT Sbjct: 86 HIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKDLYKDFLTLEH 145 Query: 133 IRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRV 192 + Y +++ K +++ S +HRD+ N+++ E +++ D+GLA + +Y + Sbjct: 146 LICYSFQVAKGMEFLASRKCIHRDLAARNILLS-EKNVVKICDFGLARDIYKDPDYVRKG 204 Query: 193 ASRY---FKGPELLVDYQMYDYSLDMWSLGCML 222 +R + PE + D ++Y D+WS G +L Sbjct: 205 DARLPLKWMAPETIFD-RVYTIQSDVWSFGVLL 236 >2FO0-A nrPDB Length = 495 Score = 54.3 bits (129), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 43/195 (22%), Positives = 92/195 (47%), Gaps = 12/195 (6%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK--PVKKKKIKREIKILENLRGGPN 93 + D + KLG G+Y EV+E + + V VK LK ++ ++ +E +++ ++ PN Sbjct: 216 RTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIK-HPN 274 Query: 94 IITLADIV-KDPVSRTPALVFEHVNNTDF-KQLYQTLTDYDIRFYM-YEILKALDYCHSM 150 ++ L + ++P + N D+ ++ + + + YM +I A++Y Sbjct: 275 LVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKK 334 Query: 151 GIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLVDYQ 207 +HR++ N ++ H +++ D+GL+ G Y +++ + PE L Y Sbjct: 335 NFIHRNLAARNCLVGENHL-VKVADFGLSRLM-TGDTYTAHAGAKFPIKWTAPESLA-YN 391 Query: 208 MYDYSLDMWSLGCML 222 + D+W+ G +L Sbjct: 392 KFSIKSDVWAFGVLL 406 >4LQP-A nrPDB Length = 508 Score = 54.3 bits (129), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 43/163 (26%), Positives = 80/163 (49%), Gaps = 15/163 (9%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVV--KILKPVKKKK-----IKREIKILENLR 89 +D+ V+ +G+G + EV + + K+ +LK KK +K E +L Sbjct: 102 EDFHTVKVIGKGAFGEV-RLVQKKDTGKIYAMKTLLKSEMYKKDQLAHVKAERDVLAG-S 159 Query: 90 GGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQL---YQTLTDYDIRFYMYEILKALDY 146 P +++L +D ++ L+ E + D + +Q T+ RFYM E + A++ Sbjct: 160 DSPWVVSLYYSFQD--AQYLYLIMEFLPGGDLMTMLIRWQLFTEDVTRFYMAECILAIET 217 Query: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYN 189 H +G +HR +KP N++ID ++L D+GL+ +H + N Sbjct: 218 IHKLGFIHRAIKPDNILIDIRGH-IKLSDFGLSTGFHKTHDSN 259 >2BUJ-A nrPDB Length = 317 Score = 54.3 bits (129), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 58/236 (24%), Positives = 111/236 (47%), Gaps = 27/236 (11%) Query: 21 REYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL---KPVKKKK 77 RE ++ H+V N+ Y ++KLG G +S V + + +K + + +++ Sbjct: 14 RENLYFQGHMVIIDNKH-YLFIQKLGEGGFSYVDLVEGLHDGHFYALKRILCHEQQDREE 72 Query: 78 IKREIKILENLRGGPNIITL-ADIVKDPVSRTPALVF-------EHVNNTD-FKQLYQTL 128 +RE + L PNI+ L A +++ ++ A + N + K L Sbjct: 73 AQREAD-MHRLFNHPNILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFL 131 Query: 129 TDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWG---LAEFYHPG 185 T+ I + + I + L+ H+ G HRD+KP N+++ E + + L+D G A + G Sbjct: 132 TEDQILWLLLGICRGLEAIHAKGYAHRDLKPTNILLGDEGQPV-LMDLGSMNQACIHVEG 190 Query: 186 -------QEYNVRVASRYFKGPELLV--DYQMYDYSLDMWSLGCMLASMIFRKEPF 232 Q++ + + ++ PEL + + D D+WSLGC+L +M+F + P+ Sbjct: 191 SRQALTLQDWAAQRCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPY 246 >3BEA-A nrPDB Length = 333 Score = 54.3 bits (129), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 54/214 (25%), Positives = 94/214 (43%), Gaps = 29/214 (13%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNE-----KVVVKILKPV----KKKKIKREIKILE 86 +++ Q + LG G + +V EA + KV VK+LK +K+ + E+KI+ Sbjct: 45 RNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMS 104 Query: 87 NLRGGPNIITLAD---------IVKDPVSRTPALVF----EHVNNTD--FKQLYQTLTDY 131 +L NI+ L ++ + L F V TD F TL+ Sbjct: 105 HLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKSRVLETDPAFAIANSTLSTR 164 Query: 132 DIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVR 191 D+ + ++ + + + S +HRDV NV++ + H ++ D+GLA Y V+ Sbjct: 165 DLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVA-KIGDFGLARDIMNDSNYIVK 223 Query: 192 VASRY---FKGPELLVDYQMYDYSLDMWSLGCML 222 +R + PE + D +Y D+WS G +L Sbjct: 224 GNARLPVKWMAPESIFDC-VYTVQSDVWSYGILL 256 >6NPU-A nrPDB Length = 298 Score = 53.9 bits (128), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 44/193 (22%), Positives = 91/193 (47%), Gaps = 12/193 (6%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK--PVKKKKIKREIKILENLRGGPNII 95 D + KLG G+Y EV+E + + V VK LK ++ ++ +E +++ ++ PN++ Sbjct: 27 DITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIK-HPNLV 85 Query: 96 TLADIV-KDPVSRTPALVFEHVNNTDF-KQLYQTLTDYDIRFYM-YEILKALDYCHSMGI 152 L + ++P + N D+ ++ + + + YM +I A++Y Sbjct: 86 QLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNF 145 Query: 153 MHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLVDYQMY 209 +HRD+ N ++ H +++ D+GL+ G Y +++ + PE L Y + Sbjct: 146 IHRDLAARNCLVGENHL-VKVADFGLSRL-MTGDTYTAHAGAKFPIKWTAPESLA-YNKF 202 Query: 210 DYSLDMWSLGCML 222 D+W+ G +L Sbjct: 203 SIKSDVWAFGVLL 215 >5O0Y-A nrPDB Length = 579 Score = 53.9 bits (128), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 70/303 (23%), Positives = 128/303 (42%), Gaps = 62/303 (20%) Query: 50 YSEVFEAINITNNEKVVVKILKPVKK----------KKIKREIKILENLRGGPNIITLAD 99 +SEV++A ++T V VKI + K K RE +I + L P I+ L D Sbjct: 297 FSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKEL-DHPRIVKLYD 355 Query: 100 IVK-DPVSRTPALVFEHVNNTDF--KQLYQTLTDYDIRFYMYEILKALDYCHSMG--IMH 154 D S L + N+ DF KQ ++ +++ + R + +I+ AL Y + + I+H Sbjct: 356 YFSLDTDSFCTVLEYCEGNDLDFYLKQ-HKLMSEKEARSIIMQIVNALKYLNEIKPPIIH 414 Query: 155 RDVKPHNVMIDH--EHRKLRLIDWGLAEFYH-------PGQEYNVRVASRY-FKGPELLV 204 D+KP N+++ + ++++ D+GL++ G E + A Y + PE V Sbjct: 415 YDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFV 474 Query: 205 ---DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKY 261 + +D+WS+G + ++ ++PF H D L + TE Sbjct: 475 VGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATE--------- 525 Query: 262 NIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEH 321 ++ P+ +V+PEA F+ + L Y + R+ ++ Sbjct: 526 -VQFPPK----------------------PVVTPEAKAFIRRCLAYRKEDRIDVQQLACD 562 Query: 322 PYF 324 PY Sbjct: 563 PYL 565 >5KKR-C nrPDB Length = 395 Score = 53.9 bits (128), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 50/208 (24%), Positives = 91/208 (43%), Gaps = 22/208 (10%) Query: 37 DDYQLVRKLGRGKYSEVFEAI----NITNNEKVVVKILKPVKKKKIKREIKILENLRGGP 92 DD++ + +LG G VF+ + K++ +KP + +I RE+++L P Sbjct: 68 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNS-P 126 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYCHS 149 I+ ++ EH++ Q+ + + + + ++K L Y Sbjct: 127 YIVGFYGAFYS--DGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLRE 184 Query: 150 M-GIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ----EYNVRVASRYFKGPELLV 204 IMHRDVKP N++++ +++L D+G++ GQ N V +R + PE L Sbjct: 185 KHKIMHRDVKPSNILVN-SRGEIKLCDFGVS-----GQLIDSMANSFVGTRSYMSPERLQ 238 Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPF 232 Y D+WS+G L M + P Sbjct: 239 GTH-YSVQSDIWSMGLSLVEMAVGRYPI 265 >3EQC-A nrPDB Length = 360 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 50/208 (24%), Positives = 91/208 (43%), Gaps = 22/208 (10%) Query: 37 DDYQLVRKLGRGKYSEVFEAI----NITNNEKVVVKILKPVKKKKIKREIKILENLRGGP 92 DD++ + +LG G VF+ + K++ +KP + +I RE+++L P Sbjct: 33 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNS-P 91 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYCHS 149 I+ ++ EH++ Q+ + + + + ++K L Y Sbjct: 92 YIVGFYGAFYS--DGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLRE 149 Query: 150 M-GIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ----EYNVRVASRYFKGPELLV 204 IMHRDVKP N++++ +++L D+G++ GQ N V +R + PE L Sbjct: 150 KHKIMHRDVKPSNILVN-SRGEIKLCDFGVS-----GQLIDSMANSFVGTRSYMSPERLQ 203 Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPF 232 Y D+WS+G L M + P Sbjct: 204 GTH-YSVQSDIWSMGLSLVEMAVGRYPI 230 >4AN9-A nrPDB Length = 301 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 50/207 (24%), Positives = 91/207 (43%), Gaps = 22/207 (10%) Query: 37 DDYQLVRKLGRGKYSEVFEAI----NITNNEKVVVKILKPVKKKKIKREIKILENLRGGP 92 DD++ + +LG G VF+ + K++ +KP + +I RE+++L P Sbjct: 9 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNS-P 67 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYCHS 149 I+ ++ EH++ Q+ + + + + ++K L Y Sbjct: 68 YIVGFYGAFYS--DGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLRE 125 Query: 150 M-GIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ----EYNVRVASRYFKGPELLV 204 IMHRDVKP N++++ +++L D+G++ GQ N V +R + PE L Sbjct: 126 KHKIMHRDVKPSNILVN-SRGEIKLCDFGVS-----GQLIDEMANEFVGTRSYMSPERLQ 179 Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEP 231 Y D+WS+G L M + P Sbjct: 180 GTH-YSVQSDIWSMGLSLVEMAVGRYP 205 >6CTH-A nrPDB Length = 309 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 62/249 (24%), Positives = 111/249 (44%), Gaps = 25/249 (10%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKR---EIKILENLRGGPNI 94 ++ KLG G + V+ ++ + VK + K+ IK E+KI+ LR N+ Sbjct: 16 NFNAENKLGEGGFGSVYRGFLRDSDTYIAVKKVSRASKQGIKEYASEVKIISRLRH-KNL 74 Query: 95 ITLADIVKDPVSRTPALVFEHVNNTD-----FKQLYQTLTDYDIRFYMY-EILKALDYCH 148 + L + LV+E + N FK ++L +++R+ + ++ AL Y H Sbjct: 75 VKLIGWCHE--RGELMLVYEFMANGSLDSHIFKG--KSLLTWEVRYRIVKDLASALLYLH 130 Query: 149 SMG---IMHRDVKPHNVMIDHEHRKLRLIDWGLAEF--YHPGQEYNVRVASRYFKGPELL 203 G ++HRD+K N+M+D +L D+GLA + G + + + + PE L Sbjct: 131 EEGDHCVLHRDIKTSNIMLDSSFNA-KLGDFGLARLVDHAKGLKKTLLAGTVGYMAPECL 189 Query: 204 VDYQMYDYSLDMWSLGCM---LASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYID- 259 + S D++S G + +AS EP F + + + + G E + D D Sbjct: 190 SSGKASKES-DVYSFGVVALEIASGRRSIEPKFEESEALLLVPWVWESYGNERILDIADR 248 Query: 260 KYNIELDPR 268 K + DP+ Sbjct: 249 KLGMAFDPK 257 >4M7I-A nrPDB Length = 299 Score = 52.8 bits (125), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 49/223 (21%), Positives = 105/223 (47%), Gaps = 36/223 (16%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK----PVKKKKIKREIKILENLRGGPN 93 D++ ++ LGRG + VFEA N ++ +K ++ + ++K+ RE+K L L P Sbjct: 6 DFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEH-PG 64 Query: 94 IIT-----LADIVKDPVSRTPALVFEHV--------NNTDFKQLYQTLTDYDIRFYMY-- 138 I+ L + + + V+ ++ N D+ T+ + + ++ Sbjct: 65 IVRYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIF 124 Query: 139 -EILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE---------- 187 +I +A+++ HS G+MHRD+KP N+ + +++ D+GL +E Sbjct: 125 LQIAEAVEFLHSKGLMHRDLKPSNIFFTMDD-VVKVGDFGLVTAMDQDEEEQTVLTPMPA 183 Query: 188 ---YNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIF 227 + +V ++ + PE + Y + +D++SLG +L +++ Sbjct: 184 YARHTGQVGTKLYMSPE-QIHGNSYSHKVDIFSLGLILFELLY 225 >5VD3-A nrPDB Length = 311 Score = 52.8 bits (125), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 51/218 (23%), Positives = 91/218 (41%), Gaps = 20/218 (9%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVK-----ILKPVKKKKIKREIKILENLRG 90 Q +Q + +LG G Y EVF+ + + VK P + + E+ E + Sbjct: 56 QQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQ 115 Query: 91 GPNIITLADIVKDPVSRTPALVF--EHVNNTDFKQLYQ----TLTDYDIRFYMYEILKAL 144 P + L ++ +++ + +Q + +L + + Y+ + L AL Sbjct: 116 HPCCVRLEQAWEEG-----GILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLAL 170 Query: 145 DYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLV 204 + HS G++H DVKP N+ + R +L D+GL V+ + PELL Sbjct: 171 AHLHSQGLVHLDVKPANIFLGPRGR-CKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQ 229 Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQL 242 Y + D++SLG + + E HG + + QL Sbjct: 230 GS--YGTAADVFSLGLTILEVACNME-LPHGGEGWQQL 264 >3A4O-X nrPDB Length = 286 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 50/225 (22%), Positives = 105/225 (46%), Gaps = 23/225 (10%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP--VKKKKIKREIKILENLRGGP- 92 ++ +LV++LG G++ EV+ N+ KV VK LKP + + E +++ L+ Sbjct: 12 RESIKLVKRLGAGQFGEVWMGY-YNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKL 70 Query: 93 ----NIITLAD---IVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALD 145 ++T + I+ + +++ L F ++ K L L D+ +I + + Sbjct: 71 VRLYAVVTREEPIYIITEYMAKGSLLDFLK-SDEGGKVLLPKLIDFSA-----QIAEGMA 124 Query: 146 YCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPEL 202 Y +HRD++ NV++ E ++ D+GLA EY R +++ + PE Sbjct: 125 YIERKNYIHRDLRAANVLV-SESLMCKIADFGLARVIE-DNEYTAREGAKFPIKWTAPE- 181 Query: 203 LVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAK 247 +++ + D+WS G +L ++ + + G N D + +++ Sbjct: 182 AINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQ 226 >3PLS-A nrPDB Length = 298 Score = 52.0 bits (123), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 51/215 (23%), Positives = 99/215 (46%), Gaps = 22/215 (10%) Query: 43 RKLGRGKYSEVF--EAINITNNE-----KVVVKILKPVKKKKIKREIKILENLRGGPNII 95 R +G+G + V+ E I+ N K + +I + + + RE ++ L PN++ Sbjct: 27 RVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGL-NHPNVL 85 Query: 96 TLADIVKDPVSRTPALVFEHVNNTDFKQLYQTL----TDYDIRFYMYEILKALDYCHSMG 151 L I+ P P ++ ++ + D Q ++ T D+ + ++ + ++Y Sbjct: 86 ALIGIMLPP-EGLPHVLLPYMCHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLAEQK 144 Query: 152 IMHRDVKPHNVMIDHEHRKLRLIDWGLA------EFYHPGQEYNVRVASRYFKGPELLVD 205 +HRD+ N M+D E +++ D+GLA E+Y Q + R+ ++ E L Sbjct: 145 FVHRDLAARNCMLD-ESFTVKVADFGLARDILDREYYSVQQHRHARLPVKW-TALESLQT 202 Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYD 240 Y+ S D+WS G +L ++ R P + D +D Sbjct: 203 YRFTTKS-DVWSFGVLLWELLTRGAPPYRHIDPFD 236 >3PP0-A nrPDB Length = 338 Score = 52.0 bits (123), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 73/308 (23%), Positives = 133/308 (43%), Gaps = 41/308 (13%) Query: 42 VRKLGRGKYSEVFEAINITNNEKV----VVKILK----PVKKKKIKREIKILENLRGGPN 93 V+ LG G + V++ I I + E V +K+L+ P K+I E ++ + G P Sbjct: 22 VKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGV-GSPY 80 Query: 94 I-----ITLADIVKDPVSRTP-ALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYC 147 + I L V+ P + +HV + L D+ + +I K + Y Sbjct: 81 VSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGR-----LGSQDLLNWCMQIAKGMSYL 135 Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ-EYNV---RVASRYFKGPELL 203 + ++HRD+ NV++ + +++ D+GLA + EY+ +V ++ +L Sbjct: 136 EDVRLVHRDLAARNVLVKSPNH-VKITDFGLARLLDIDETEYHADGGKVPIKWMALESIL 194 Query: 204 VDYQMYDYSLDMWSLGCMLAS-MIFRKEPF--FHGHDNYDQLVRIAKV----LGTEDLYD 256 + + + D+WS G + M F +P+ + D L + ++ + T D+Y Sbjct: 195 --RRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYM 252 Query: 257 YIDKY---NIELDPRFNDILGRHSR--KRWERFVHSENQHLVSPEALD--FLDKLLRYDH 309 + K + E PRF +++ SR + +RFV +N+ L LD F LL D Sbjct: 253 IMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDD 312 Query: 310 QSRLTARE 317 L E Sbjct: 313 MGDLVDAE 320 >2CMW-A nrPDB Length = 310 Score = 52.0 bits (123), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 41/153 (26%), Positives = 74/153 (48%), Gaps = 19/153 (12%) Query: 43 RKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK--KIKREIKILENL----RGGPNIIT 96 +K+G G + E+ N+ NE V +K L+P+K + ++ E + + L G P + Sbjct: 6 KKIGCGNFGELRLGKNLYTNEYVAIK-LEPIKSRAPQLHLEYRFYKQLGSAGEGLPQVYY 64 Query: 97 LADIVKDPVSRTPALVFEHVNNTD---FKQLYQTLTDYDIRFYMYEILKALDYCHSMGIM 153 P + A+V E + + F +T T + ++L ++Y HS ++ Sbjct: 65 FG-----PCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYVHSKNLI 119 Query: 154 HRDVKPHNVMIDHEHRK----LRLIDWGLAEFY 182 +RDVKP N +I + K + +ID+GLA+ Y Sbjct: 120 YRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEY 152 >5HLW-A nrPDB Length = 299 Score = 51.6 bits (122), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 58/261 (22%), Positives = 115/261 (44%), Gaps = 34/261 (13%) Query: 45 LGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIK------ILENLRGGPNIITLA 98 +GRG + V+ + N+ K + +K + + E+ I+ PN+++L Sbjct: 28 IGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLL 87 Query: 99 DIVKDPVSRTPALVFEHVNNTDFKQLYQTLTD----YDIRFYMYEILKALDYCHSMGIMH 154 I +P +V ++ + D + + T D+ + ++ K + Y S +H Sbjct: 88 GICLRS-EGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVH 146 Query: 155 RDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDY-------- 206 RD+ N M+D E +++ D+GLA H + Y+V + G +L V + Sbjct: 147 RDLAARNCMLD-EKFTVKVADFGLARDMHDKEYYSVHNKT----GAKLPVKWMALESLQT 201 Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYD---QLVRIAKVLGTE----DLYDYID 259 Q + D+WS G +L ++ R P + + +D L++ ++L E LY+ + Sbjct: 202 QKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVML 261 Query: 260 KY---NIELDPRFNDILGRHS 277 K E+ P F++++ R S Sbjct: 262 KCWHPKAEMRPSFSELVSRIS 282 >5X02-A nrPDB Length = 347 Score = 51.6 bits (122), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 59/251 (23%), Positives = 107/251 (42%), Gaps = 54/251 (21%) Query: 12 YTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEA----INITN-NEKVV 66 Y D + W++ +E+G + LG G + +V A I+ T + +V Sbjct: 31 YVDFREYEYDLKWEFPRENLEFG--------KVLGSGAFGKVMNATAYGISKTGVSIQVA 82 Query: 67 VKILK----PVKKKKIKREIKILENLRGGPNIITL--ADIVKDPVSRTPALVFEHVNNTD 120 VK+LK +++ + E+K++ L NI+ L A + P+ L+FE+ D Sbjct: 83 VKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPI----YLIFEYCCYGD 138 Query: 121 F---------------------KQLYQ-----TLTDYDIRFYMYEILKALDYCHSMGIMH 154 K+L + LT D+ + Y++ K +++ +H Sbjct: 139 LLNYLRSKREKFSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVH 198 Query: 155 RDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLVDYQMYDY 211 RD+ NV++ H + +++ D+GLA Y VR +R + PE L + +Y Sbjct: 199 RDLAARNVLVTH-GKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFE-GIYTI 256 Query: 212 SLDMWSLGCML 222 D+WS G +L Sbjct: 257 KSDVWSYGILL 267 >2PL0-A nrPDB Length = 289 Score = 51.6 bits (122), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 47/223 (21%), Positives = 102/223 (45%), Gaps = 23/223 (10%) Query: 15 VNTHRPRE-YWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK-- 71 + T +P++ +W+ E V ++ +LV +LG G++ EV+ + KV VK LK Sbjct: 4 MQTQKPQKPWWEDEWEV----PRETLKLVERLGAGQFGEVWMGY-YNGHTKVAVKSLKQG 58 Query: 72 PVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---- 127 + E +++ L+ + A + ++P+ ++ E++ N +T Sbjct: 59 SMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIY----IITEYMENGSLVDFLKTPSGI 114 Query: 128 -LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ 186 LT + +I + + + +HRD++ N+++ + ++ D+GLA Sbjct: 115 KLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVS-DTLSCKIADFGLARLIE-DN 172 Query: 187 EYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMI 226 EY R +++ + PE ++Y + D+WS G +L ++ Sbjct: 173 EYTAREGAKFPIKWTAPEA-INYGTFTIKSDVWSFGILLTEIV 214 >5TE0-A nrPDB Length = 347 Score = 51.2 bits (121), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 56/215 (26%), Positives = 100/215 (46%), Gaps = 31/215 (14%) Query: 45 LGRGKYSEVFEAINITNNEKVVVKILKPVKK---KKIKREIKILENLRGGPNIITLADIV 101 L G ++ VF + +N K +K + + + KREI+I+ +L G NI+ D Sbjct: 27 LAEGGFAIVF-LVRTSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSS 85 Query: 102 KDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIR----FYMYEILKAL-DYCHSMG----- 151 + VS V+E + DF + Q + + R F E+L+ D C ++ Sbjct: 86 INNVSSGD--VWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQC 143 Query: 152 ---IMHRDVKPHNVMIDHEHRKLRLIDWGLA--EFYHPGQE-YNV------RVASRYFKG 199 I+HRD+K N+++ H+ L D+G A +F +P E N + + ++ Sbjct: 144 KTPIIHRDLKVENILL-HDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYRA 202 Query: 200 PELLVDY--QMYDYSLDMWSLGCMLASMIFRKEPF 232 PE++ Y ++ D+W+LGC+L + + PF Sbjct: 203 PEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPF 237 >5HVK-A nrPDB Length = 315 Score = 51.2 bits (121), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 49/211 (23%), Positives = 102/211 (48%), Gaps = 37/211 (17%) Query: 45 LGRGKYSEVFEAINITNNEKVVVKILKPV------KKKKIKREIKILENLRGGPNIITLA 98 LG+G + + AI +T+ E V ++K + ++ +E+K++ L PN++ Sbjct: 22 LGKGCFGQ---AIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEH-PNVLKFI 77 Query: 99 DIV-KDPVSRTPALVFEHVNNTDFKQLYQTLTD---YDIRF-YMYEILKALDYCHSMGIM 153 ++ KD + + E++ + + +++ + R + +I + Y HSM I+ Sbjct: 78 GVLYKD---KRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNII 134 Query: 154 HRDVKPHNVMIDHEHRKLRLIDWGLA-----EFYHP-----------GQEYNVRVASRYF 197 HR++ HN ++ E++ + + D+GLA E P + Y V V + Y+ Sbjct: 135 HRNLNSHNCLV-RENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTV-VGNPYW 192 Query: 198 KGPELLVDYQMYDYSLDMWSLGCMLASMIFR 228 PE +++ + YD +D++S G +L +I R Sbjct: 193 MAPE-MINGRSYDEKVDVFSFGIVLCEIIGR 222 >2C47-A nrPDB Length = 313 Score = 51.2 bits (121), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 39/157 (24%), Positives = 75/157 (47%), Gaps = 18/157 (11%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIK-----REIKILENLRGGP 92 ++++ +K+G G + E+ N+ NE V +K L+P+K + + R K L G P Sbjct: 5 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIK-LEPIKSRAPQLHLEYRFYKQLSATEGVP 63 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNTD---FKQLYQTLTDYDIRFYMYEILKALDYCHS 149 + P + A+V E + + F +T T + +++ ++Y H+ Sbjct: 64 QVYYFG-----PCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYVHT 118 Query: 150 MGIMHRDVKPHNVMIDHEHRK----LRLIDWGLAEFY 182 +++RDVKP N ++ K + +ID+GLA+ Y Sbjct: 119 KSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEY 155 >5A46-A nrPDB Length = 386 Score = 51.2 bits (121), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 53/222 (23%), Positives = 98/222 (44%), Gaps = 41/222 (18%) Query: 36 QDDYQLVRKLGRGKYSEVF--EAINITNNE-----KVVVKILKPVKKKK----IKREIKI 84 +D L + LG G + +V EAI + ++ KV VK+LK +K + E+++ Sbjct: 39 RDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEM 98 Query: 85 LENLRGGPNIITL--ADIVKDPVSRTPALVFEHVNNTDFKQLYQT--------------- 127 ++ + NII L A P+ ++ E+ + + ++ Q Sbjct: 99 MKMIGKHKNIINLLGACTQDGPL----YVIVEYASKGNLREYLQARRPPGLEYCYNPSHN 154 Query: 128 ----LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH 183 L+ D+ Y++ + ++Y S +HRD+ NV++ E +++ D+GLA H Sbjct: 155 PEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVT-EDNVMKIADFGLARDIH 213 Query: 184 PGQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCML 222 Y R + PE L D ++Y + D+WS G +L Sbjct: 214 HIDYYKKTTNGRLPVKWMAPEALFD-RIYTHQSDVWSFGVLL 254 >4XUF-A nrPDB Length = 297 Score = 50.8 bits (120), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 57/239 (23%), Positives = 104/239 (43%), Gaps = 54/239 (22%) Query: 24 WDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEA----INITN-NEKVVVKILK----PVK 74 W++ +E+G + LG G + +V A I+ T + +V VK+LK + Sbjct: 4 WEFPRENLEFG--------KVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSE 55 Query: 75 KKKIKREIKILENLRGGPNIITL--ADIVKDPVSRTPALVFEHVNNTDF----------- 121 ++ + E+K++ L NI+ L A + P+ L+FE+ D Sbjct: 56 REALMSELKMMTQLGSHENIVNLLGACTLSGPI----YLIFEYCCYGDLLNYLRSKREKF 111 Query: 122 ----------KQLYQ-----TLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDH 166 K+L + LT D+ + Y++ K +++ +HRD+ NV++ H Sbjct: 112 SEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTH 171 Query: 167 EHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCML 222 + +++ D+GLA Y VR +R + PE L + +Y D+WS G +L Sbjct: 172 -GKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFE-GIYTIKSDVWSYGILL 228 >3TT0-A nrPDB Length = 382 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 53/222 (23%), Positives = 98/222 (44%), Gaps = 41/222 (18%) Query: 36 QDDYQLVRKLGRGKYSEVF--EAINITNNE-----KVVVKILKPVKKKK----IKREIKI 84 +D L + LG G + +V EAI + ++ KV VK+LK +K + E+++ Sbjct: 68 RDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEM 127 Query: 85 LENLRGGPNIITL--ADIVKDPVSRTPALVFEHVNNTDFKQLYQT--------------- 127 ++ + NII L A P+ ++ E+ + + ++ Q Sbjct: 128 MKMIGKHKNIINLLGACTQDGPLY----VIVEYASKGNLREYLQARRPPGLEYSYNPSHN 183 Query: 128 ----LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH 183 L+ D+ Y++ + ++Y S +HRD+ NV++ E +++ D+GLA H Sbjct: 184 PEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVT-EDNVMKIADFGLARDIH 242 Query: 184 PGQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCML 222 Y R + PE L D ++Y + D+WS G +L Sbjct: 243 HIDYYKKTTNGRLPVKWMAPEALFD-RIYTHQSDVWSFGVLL 283 >3GQL-A nrPDB Length = 326 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 53/222 (23%), Positives = 98/222 (44%), Gaps = 41/222 (18%) Query: 36 QDDYQLVRKLGRGKYSEVF--EAINITNNE-----KVVVKILKPVKKKK----IKREIKI 84 +D L + LG G + +V EAI + ++ KV VK+LK +K + E+++ Sbjct: 27 RDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEM 86 Query: 85 LENLRGGPNIITL--ADIVKDPVSRTPALVFEHVNNTDFKQLYQT--------------- 127 ++ + NII L A P+ ++ E+ + + ++ Q Sbjct: 87 MKMIGKHKNIINLLGACTQDGPLY----VIVEYASKGNLREYLQARRPPGLEYCYNPSHN 142 Query: 128 ----LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH 183 L+ D+ Y++ + ++Y S +HRD+ NV++ E +++ D+GLA H Sbjct: 143 PEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVT-EDNVMKIADFGLARDIH 201 Query: 184 PGQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCML 222 Y R + PE L D ++Y + D+WS G +L Sbjct: 202 HIDYYKKTTNGRLPVKWMAPEALFD-RIYTHQSDVWSFGVLL 242 >5SYS-A nrPDB Length = 286 Score = 50.1 bits (118), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 45/222 (20%), Positives = 98/222 (44%), Gaps = 18/222 (8%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP--VKKKKIKREIKILENLRGGPN 93 ++ +L KLG+G + E + +V +K LKP + + +E ++++ LR Sbjct: 17 RESLRLEVKLGQGCFGECWMG-TWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKL 75 Query: 94 IITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRF-----YMYEILKALDYCH 148 + A + ++P+ +V E+++ + +R +I + Y Sbjct: 76 VQLYAVVSEEPIY----IVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVE 131 Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLVD 205 M +HRD++ N+++ E+ ++ D+GLA EY R +++ + PE + Sbjct: 132 RMNYVHRDLRAANILVG-ENLVCKVADFGLARLIE-DNEYTARQGAKFPIKWTAPEAAL- 188 Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAK 247 Y + D+WS G +L + + + G N + L ++ + Sbjct: 189 YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER 230 >2XYN-A nrPDB Length = 292 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 42/196 (21%), Positives = 89/196 (45%), Gaps = 12/196 (6%) Query: 35 NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK--PVKKKKIKREIKILENLRGGP 92 + D + KLG G+Y EV+ + + V VK LK ++ ++ +E +++ ++ P Sbjct: 30 ERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKH-P 88 Query: 93 NIITLADIVK-DPVSRTPALVFEHVNNTDFKQLY--QTLTDYDIRFYMYEILKALDYCHS 149 N++ L + +P + N D+ + + +T + + +I A++Y Sbjct: 89 NLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEK 148 Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLVDY 206 +HRD+ N ++ H +++ D+GL+ G Y +++ + PE L Y Sbjct: 149 KNFIHRDLAARNCLVGENHV-VKVADFGLSRL-MTGDTYTAHAGAKFPIKWTAPESLA-Y 205 Query: 207 QMYDYSLDMWSLGCML 222 + D+W+ G +L Sbjct: 206 NTFSIKSDVWAFGVLL 221 >4EBW-A nrPDB Length = 304 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 49/226 (21%), Positives = 100/226 (44%), Gaps = 23/226 (10%) Query: 35 NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK-------KKKIKREIKILEN 87 ++ +L R +G G++ +V + I ++ + +K K ++K +E + Sbjct: 36 QRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQ 95 Query: 88 LRGGPNIITLADIV-KDPVSRTPALVFEHVNNTDFKQLYQ----TLTDYDIRFYMYEILK 142 P+I+ L ++ ++PV ++ E + + Q +L + Y Y++ Sbjct: 96 F-DHPHIVKLIGVITENPV----WIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLST 150 Query: 143 ALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFK--GP 200 AL Y S +HRD+ NV++ + ++L D+GL+ + Y K P Sbjct: 151 ALAYLESKRFVHRDIAARNVLVS-SNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAP 209 Query: 201 ELLVDYQMYDYSLDMWSLG-CMLASMIFRKEPFFHGHDNYDQLVRI 245 E ++++ + + D+W G CM ++ +P F G N D + RI Sbjct: 210 E-SINFRRFTSASDVWMFGVCMWEILMHGVKP-FQGVKNNDVIGRI 253 >3KRL-A nrPDB Length = 335 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 52/219 (23%), Positives = 95/219 (43%), Gaps = 37/219 (16%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNE-----KVVVKILKPV----KKKKIKREIKILE 86 +++ Q + LG G + +V EA + KV VK+LK +K+ + E+KI+ Sbjct: 45 RNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMS 104 Query: 87 NLRGGPNIITLADIVK--DPV------------------SRTPALVFEHVNNTDFKQLYQ 126 +L NI+ L PV R P L + + + + ++ Sbjct: 105 HLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKRPPGLEYSYNPSHNPEE--- 161 Query: 127 TLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ 186 L+ D+ + ++ + + + S +HRDV NV++ + H ++ D+GLA Sbjct: 162 QLSSRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVA-KIGDFGLARDIMNDS 220 Query: 187 EYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCML 222 Y V+ +R + PE + D +Y D+WS G +L Sbjct: 221 NYIVKGNARLPVKWMAPESIFDC-VYTVQSDVWSYGILL 258 >5GRN-A nrPDB Length = 356 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 58/227 (25%), Positives = 99/227 (43%), Gaps = 43/227 (18%) Query: 36 QDDYQLVRKLGRGKYSEVFE--AINITNNE---KVVVKILKPV----KKKKIKREIKILE 86 +D L R LG G + +V E A ++ ++ KV VK+LKP +K+ + E+KI+ Sbjct: 45 RDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMT 104 Query: 87 NLRGGPNIITL--ADIVKDPVSRTPALVFE-------HVNNTDF-------------KQL 124 +L NI+ L A P+ F H N F K L Sbjct: 105 HLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHKKKSMLDSEVKNL 164 Query: 125 Y-----QTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA 179 + LT D+ + Y++ + +++ S +HRD+ NV++ + + +++ D+GLA Sbjct: 165 LSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLL-AQGKIVKICDFGLA 223 Query: 180 EFYHPGQEYNVRVASRY----FKGPELLVDYQMYDYSLDMWSLGCML 222 Y V S + + PE + D +Y D+WS G +L Sbjct: 224 RDIMHDSNY-VSKGSTFLPVKWMAPESIFD-NLYTTLSDVWSYGILL 268 >2A1A-B nrPDB Length = 284 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 55/232 (23%), Positives = 105/232 (45%), Gaps = 31/232 (13%) Query: 28 SHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILEN 87 +H V+ D++ + +G G + +VF+A + + + V+K +K +K +RE+K L Sbjct: 2 AHTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVK-YNNEKAEREVKALAK 60 Query: 88 LRGGPNIITLADI-----------VKDPVSRTPALVFEHVNNTDFKQLYQTLT------- 129 L NI+ K+ +F + D L Q + Sbjct: 61 L-DHVNIVHYNGCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKL 119 Query: 130 DYDIRFYMYE-ILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGL-AEFYHPGQE 187 D + ++E I K +DY HS +++RD+KP N+ + + +++++ D+GL + G+ Sbjct: 120 DKVLALELFEQITKGVDYIHSKKLINRDLKPSNIFL-VDTKQVKIGDFGLVTSLKNDGKR 178 Query: 188 YNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMI------FRKEPFF 233 + RY PE + Q Y +D+++LG +LA ++ F FF Sbjct: 179 TRSKGTLRYM-SPE-QISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFF 228 >2OGV-A nrPDB Length = 317 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 53/213 (24%), Positives = 92/213 (43%), Gaps = 31/213 (14%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNE-----KVVVKILKPV----KKKKIKREIKILE 86 +++ Q + LG G + +V EA + KV VK+LK +K+ + E+KI+ Sbjct: 37 RNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMS 96 Query: 87 NLRGGPNIITLADIVKDPVSRTPALVF-EHVNNTDF-------------KQLYQTLTDYD 132 +L NI+ L P LV E+ D K+ + L D Sbjct: 97 HLGQHENIVNLLGAC---THGGPVLVITEYCCYGDLLNFLRRKAEADLDKEDGRPLELRD 153 Query: 133 IRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRV 192 + + ++ + + + S +HRDV NV++ + H ++ D+GLA Y V+ Sbjct: 154 LLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVA-KIGDFGLARDIMNDSNYIVKG 212 Query: 193 ASRY---FKGPELLVDYQMYDYSLDMWSLGCML 222 +R + PE + D +Y D+WS G +L Sbjct: 213 NARLPVKWMAPESIFDC-VYTVQSDVWSYGILL 244 >4TN6-A nrPDB Length = 318 Score = 49.3 bits (116), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 41/154 (26%), Positives = 77/154 (50%), Gaps = 8/154 (5%) Query: 34 GNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK--KIKREIKILENLRGG 91 GN+ Y+L RK+G G + +++ +I E+V +K L+ VK K ++ E KI + ++GG Sbjct: 6 GNR--YRLGRKIGSGSFGDIYLGTDIAAGEEVAIK-LECVKTKHPQLHIESKIYKMMQGG 62 Query: 92 PNIITLADIVKDPVSRTPALVFEHVNNTD-FKQLYQTLTDYDIRFYMYEILKALDYCHSM 150 I T+ + + + D F + + + +++ ++Y HS Sbjct: 63 VGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSK 122 Query: 151 GIMHRDVKPHNVM--IDHEHRKLRLIDWGLAEFY 182 +HRDVKP N + + + + +ID+GLA+ Y Sbjct: 123 NFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKY 156 >6GQK-A nrPDB Length = 328 Score = 48.9 bits (115), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 50/210 (23%), Positives = 90/210 (42%), Gaps = 33/210 (15%) Query: 43 RKLGRGKYSEVFEA-----INITNNEKVVVKILKP----VKKKKIKREIKILENLRGGPN 93 + LG G + +V EA I V VK+LKP +++ + E+K+L L N Sbjct: 47 KTLGAGAFGKVVEATAQGLIKSDAAMTVAVKMLKPSAHSTEREALMSELKVLSYLGNHEN 106 Query: 94 IITLAD---------IVKDPVSRTPALVFEHVNNTDF-------KQLYQT-LTDYDIRFY 136 I+ L ++ + L F +F + LY+ LT + + Sbjct: 107 IVNLLGACTHGGPTLVITEYCCYGDLLNFLRRKRDEFVPYKVAPEDLYKDFLTLEHLLSF 166 Query: 137 MYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEY----NVRV 192 Y++ K + + S +HRD+ N+++ H + ++ D+GLA Y N R+ Sbjct: 167 SYQVAKGMAFLASKNCIHRDLAARNILLTHGNIT-KICDFGLARDIKNDSNYVDKGNARL 225 Query: 193 ASRYFKGPELLVDYQMYDYSLDMWSLGCML 222 ++ PE + + +Y + D+WS G L Sbjct: 226 PVKWM-APESIFN-SVYTFESDVWSYGIFL 253 >3MY0-A nrPDB Length = 305 Score = 48.9 bits (115), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 58/215 (26%), Positives = 91/215 (42%), Gaps = 34/215 (15%) Query: 41 LVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILEN-LRGGPNIITLAD 99 LV +G+G+Y EV+ + + E V VKI ++ RE +I L NI L Sbjct: 12 LVECVGKGRYGEVWRG--LWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNI--LGF 67 Query: 100 IVKDPVSRTPALVF-------EHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCH---- 148 I D SR + EH + DF Q QTL + L + H Sbjct: 68 IASDMTSRNSSTQLWLITHYHEHGSLYDFLQ-RQTLEPHLALRLAVSAACGLAHLHVEIF 126 Query: 149 ----SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEY-----NVRVASRYFKG 199 I HRD K NV++ + + + D GLA + G +Y N RV ++ + Sbjct: 127 GTQGKPAIAHRDFKSRNVLVK-SNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMA 185 Query: 200 PELLVD------YQMYDYSLDMWSLGCMLASMIFR 228 PE+L + ++ Y ++ D+W+ G +L + R Sbjct: 186 PEVLDEQIRTDCFESYKWT-DIWAFGLVLWEIARR 219 >5IKW-A nrPDB Length = 310 Score = 48.9 bits (115), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 45/176 (25%), Positives = 80/176 (45%), Gaps = 22/176 (12%) Query: 78 IKREIKILENLRGGPNIITLADIVKDPVSRTPALVF--------EHVNNTDFKQLYQTLT 129 KREI I++ L G NI+ D + +S V V N K+L T Sbjct: 57 CKREITIMKELSGHKNIVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFT 116 Query: 130 DYDIRFYMYEILKALDYCHSMG--IMHRDVKPHNVMIDHEHRKLRLIDWGLA--EFYHPG 185 + ++ + +A+ H I+HRD+K N++++ + L D+G A +F +P Sbjct: 117 EPEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLN-DGGNYVLCDFGSATNKFLNPQ 175 Query: 186 QE-YNV------RVASRYFKGPELLVDY--QMYDYSLDMWSLGCMLASMIFRKEPF 232 ++ NV + + ++ PE++ Y + D+W+LGC+L + F PF Sbjct: 176 KDGVNVVEEEIKKYTTLSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPF 231 >1S9I-A nrPDB Length = 354 Score = 48.9 bits (115), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 48/208 (23%), Positives = 90/208 (43%), Gaps = 22/208 (10%) Query: 37 DDYQLVRKLGRGKYSEVFEA----INITNNEKVVVKILKPVKKKKIKREIKILENLRGGP 92 DD++ + +LG G V + + K++ +KP + +I RE+++L P Sbjct: 16 DDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNS-P 74 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYCHS 149 I+ ++ EH++ Q+ + + + + +L+ L Y Sbjct: 75 YIVGFYGAFYS--DGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLRE 132 Query: 150 M-GIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ----EYNVRVASRYFKGPELLV 204 IMHRDVKP N++++ +++L D+G++ GQ N V +R + PE L Sbjct: 133 KHQIMHRDVKPSNILVN-SRGEIKLCDFGVS-----GQLIDSMANSFVGTRSYMAPERLQ 186 Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPF 232 Y D+WS+G L + + P Sbjct: 187 GTH-YSVQSDIWSMGLSLVELAVGRYPI 213 >3UIU-A nrPDB Length = 306 Score = 48.9 bits (115), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 30/102 (29%), Positives = 55/102 (53%), Gaps = 10/102 (9%) Query: 139 EILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGL-AEFYHPGQEYNVRVASRYF 197 +I K +DY HS ++HRD+KP N+ + + +++++ D+GL + G+ + RY Sbjct: 144 QITKGVDYIHSKKLIHRDLKPSNIFL-VDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYM 202 Query: 198 KGPELLVDYQMYDYSLDMWSLGCMLASMI------FRKEPFF 233 PE + Q Y +D+++LG +LA ++ F FF Sbjct: 203 -SPE-QISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFF 242 >2CHL-A nrPDB Length = 351 Score = 48.5 bits (114), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 38/154 (24%), Positives = 76/154 (49%), Gaps = 12/154 (7%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK--KIKREIKILENLRGGPNII 95 ++++ +K+G G + E+ N+ NE V +K L+P+K + ++ E + + L G I Sbjct: 31 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIK-LEPMKSRAPQLHLEYRFYKQLGSGDGIP 89 Query: 96 TLADIVKDPVSRTPALVFEHVNNTD---FKQLYQTLTDYDIRFYMYEILKALDYCHSMGI 152 + P + A+V E + + F +T + + +++ ++Y HS + Sbjct: 90 QVYYF--GPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNL 147 Query: 153 MHRDVKPHNVMIDHEHRK----LRLIDWGLAEFY 182 ++RDVKP N +I K + +ID+ LA+ Y Sbjct: 148 IYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEY 181 >2HK5-A nrPDB Length = 270 Score = 48.5 bits (114), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 44/203 (21%), Positives = 92/203 (45%), Gaps = 22/203 (10%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP--VKKKKIKREIKILENLRGGPN 93 ++ +L +KLG G++ EV+ A + KV VK +KP + + E +++ L+ Sbjct: 14 RESLKLEKKLGAGQFGEVWMA-TYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKL 72 Query: 94 IITLADIVKDPV-------SRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDY 146 + A + K+P+ ++ L F + KQ L D+ +I + + + Sbjct: 73 VKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGS-KQPLPKLIDFSA-----QIAEGMAF 126 Query: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELL 203 +HRD++ N+++ ++ D+GLA EY R +++ + PE Sbjct: 127 IEQRNYIHRDLRAANILVSA-SLVCKIADFGLARVIE-DNEYTAREGAKFPIKWTAPE-A 183 Query: 204 VDYQMYDYSLDMWSLGCMLASMI 226 +++ + D+WS G +L ++ Sbjct: 184 INFGSFTIKSDVWSFGILLMEIV 206 >4TPT-A nrPDB Length = 303 Score = 48.1 bits (113), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 49/214 (22%), Positives = 99/214 (46%), Gaps = 42/214 (19%) Query: 45 LGRGKYSEVFEAINITNNEKVVVKILKPV------KKKKIKREIKILENLRGGPNIITLA 98 LG+G + + AI +T+ V ++K + +K E+K++ +L PN++ Sbjct: 8 LGKGFFGQ---AIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSL-DHPNVLKFI 63 Query: 99 DIV-KDPVSRTPALVFEHVNNTDFKQLYQTLTDY----DIRFYMYEILKALDYCHSMGIM 153 ++ KD + L+ E++ K +++ + +RF I + Y HSM I+ Sbjct: 64 GVLYKD---KKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRF-AKGIASGMAYLHSMCII 119 Query: 154 HRDVKPHNVMIDHEHRKLRLIDWGLAEFY------HPGQEYNVR---------------V 192 HRD+ HN +I + + + + D+GL+ P ++ + V Sbjct: 120 HRDLNSHNCLIKLD-KTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVV 178 Query: 193 ASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMI 226 + Y+ PE+L + + YD ++D++S G +L +I Sbjct: 179 GNPYWMAPEML-NGKSYDETVDIFSFGIVLCEII 211 >3DTC-A nrPDB Length = 271 Score = 48.1 bits (113), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 53/209 (25%), Positives = 97/209 (46%), Gaps = 30/209 (14%) Query: 45 LGRGKYSEVFEAINITNNEKVVVKILK-------PVKKKKIKREIKILENLRGGPNIITL 97 +G G + +V+ A I ++V VK + + +++E K+ L+ PNII L Sbjct: 15 IGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKH-PNIIAL 71 Query: 98 ADI-VKDPVSRTPALVFEHVNNTDFKQ-LYQTLTDYDIRF-YMYEILKALDYCHS---MG 151 + +K+P LV E + L DI + +I + ++Y H + Sbjct: 72 RGVCLKEP---NLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVP 128 Query: 152 IMHRDVKPHNVMI-------DHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY-FKGPELL 203 I+HRD+K N++I D ++ L++ D+GLA +H + + A Y + PE+ Sbjct: 129 IIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWH--RTTKMSAAGAYAWMAPEV- 185 Query: 204 VDYQMYDYSLDMWSLGCMLASMIFRKEPF 232 + M+ D+WS G +L ++ + PF Sbjct: 186 IRASMFSKGSDVWSYGVLLWELLTGEVPF 214 >3PPZ-A nrPDB Length = 309 Score = 48.1 bits (113), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 57/225 (25%), Positives = 108/225 (48%), Gaps = 33/225 (14%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL-----KPVKKKKIKREIKILENLRGGP 92 D + K+G G + V A + V VKIL + + RE+ I++ LR P Sbjct: 38 DLNIKEKIGAGSFGTVHRAE--WHGSDVAVKILMEQDFHAERVNEFLREVAIMKRLRH-P 94 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNTDFKQLY-----QTLTDYDIRFYM-YEILKALDY 146 NI+ V P + + +V E+++ +L + D R M Y++ K ++Y Sbjct: 95 NIVLFMGAVTQPPNLS--IVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAKGMNY 152 Query: 147 CHSMG--IMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKG----- 199 H+ I+HRD+K N+++D ++ +++ D+GL+ + + ++S+ G Sbjct: 153 LHNRNPPIVHRDLKSPNLLVDKKY-TVKVCDFGLSRL-----KASTFLSSKSAAGTPEWM 206 Query: 200 -PELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLV 243 PE+L D + S D++S G +L + ++P+ G+ N Q+V Sbjct: 207 APEVLRDEPSNEKS-DVYSFGVILWELATLQQPW--GNLNPAQVV 248 >4UYA-A nrPDB Length = 340 Score = 48.1 bits (113), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 46/214 (21%), Positives = 95/214 (44%), Gaps = 24/214 (11%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK-------PVKKKKIKREIKILENLR 89 + +L +G G + +V+ A ++V VK + + ++RE ++ LR Sbjct: 26 ERLELKELIGAGGFGQVYRAT--WQGQEVAVKAARQDPEQDAAAAAESVRREARLFAMLR 83 Query: 90 GGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHS 149 PNII L + L F + + + + + + +I + + Y H Sbjct: 84 H-PNIIELRGVCLQQPHLCLVLEFARGGALNRALAGRRIPPHVLVNWAVQIARGMLYLHE 142 Query: 150 MG---IMHRDVKPHNVM----IDHE---HRKLRLIDWGLAEFYHPGQEYNVRVASRY-FK 198 I+HRD+K N++ I+H+ ++ L++ D+GLA +H + + A Y + Sbjct: 143 EAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWH--RTTKMATAGAYAWM 200 Query: 199 GPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPF 232 PE ++ ++ D+WS G +L ++ + P+ Sbjct: 201 APE-VIKSSLFSKGSDIWSYGVLLWELLTGEVPY 233 >2J0K-A nrPDB Length = 656 Score = 47.8 bits (112), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 49/221 (22%), Positives = 97/221 (43%), Gaps = 23/221 (10%) Query: 40 QLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK-------KKKIKREIKILENLRGGP 92 +L R +G G++ +V + I ++ + +K K ++K +E + P Sbjct: 393 ELGRCIGEGQFGDVHQGIYMSPENPAMAVAIKTCKNCTSDSVREKFLQEALTMRQF-DHP 451 Query: 93 NIITLADIV-KDPVSRTPALVFEHVNNTDFKQLYQ----TLTDYDIRFYMYEILKALDYC 147 +I+ L ++ ++PV ++ E + + Q +L + Y Y++ AL Y Sbjct: 452 HIVKLIGVITENPV----WIIMELCTLGELRSFLQVRKFSLDLASLILYAYQLSTALAYL 507 Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFK--GPELLVD 205 S +HRD+ NV++ ++L D+GL+ + Y K PE ++ Sbjct: 508 ESKRFVHRDIAARNVLVSATD-CVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPE-SIN 565 Query: 206 YQMYDYSLDMWSLG-CMLASMIFRKEPFFHGHDNYDQLVRI 245 ++ + + D+W G CM ++ +P F G N D + RI Sbjct: 566 FRRFTSASDVWMFGVCMWEILMHGVKP-FQGVKNNDVIGRI 605 >5B2L-A nrPDB Length = 324 Score = 47.8 bits (112), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 30/111 (27%), Positives = 55/111 (49%), Gaps = 6/111 (5%) Query: 140 ILKALDYCHSM-GIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFK 198 I+KAL Y G++HRDVKP N+++D E +++L D+G++ + + Sbjct: 125 IVKALYYLKEKHGVIHRDVKPSNILLD-ERGQIKLCDFGISGRLVDSKAKTRSAGCAAYM 183 Query: 199 GPELL----VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRI 245 PE + YD D+WSLG L + + P+ + +++ L ++ Sbjct: 184 APERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKV 234 >4UY9-A nrPDB Length = 323 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 53/209 (25%), Positives = 96/209 (45%), Gaps = 30/209 (14%) Query: 45 LGRGKYSEVFEAINITNNEKVVVKILK-------PVKKKKIKREIKILENLRGGPNIITL 97 +G G + +V+ A I ++V VK + + +++E K+ L+ PNII L Sbjct: 17 IGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKH-PNIIAL 73 Query: 98 ADI-VKDPVSRTPALVFEHVNNTDFKQ-LYQTLTDYDIRF-YMYEILKALDYCHSMGI-- 152 + +K+P LV E + L DI + +I + ++Y H I Sbjct: 74 RGVCLKEP---NLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVP 130 Query: 153 -MHRDVKPHNVMI-------DHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY-FKGPELL 203 +HRD+K N++I D ++ L++ D+GLA +H + + A Y + PE+ Sbjct: 131 IIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWH--RTTKMSAAGTYAWMAPEV- 187 Query: 204 VDYQMYDYSLDMWSLGCMLASMIFRKEPF 232 + M+ D+WS G +L ++ + PF Sbjct: 188 IRASMFSKGSDVWSYGVLLWELLTGEVPF 216 >4K33-A nrPDB Length = 325 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 29/100 (29%), Positives = 50/100 (50%), Gaps = 5/100 (5%) Query: 126 QTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPG 185 + LT D+ Y++ + ++Y S +HRD+ NV++ E +++ D+GLA H Sbjct: 153 EQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLV-TEDNVMKIADFGLARDVHNL 211 Query: 186 QEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCML 222 Y R + PE L D ++Y + D+WS G +L Sbjct: 212 DYYKETTNGRLPVKWMAPEALFD-RVYTHQSDVWSFGVLL 250 >4EUU-A nrPDB Length = 319 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 48/214 (22%), Positives = 93/214 (43%), Gaps = 33/214 (15%) Query: 45 LGRGKYSEVFE----------AINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNI 94 LG+G + VF AI + NN + L+PV + RE ++L+ L NI Sbjct: 17 LGQGATANVFRGRHKKTGDLFAIKVFNN----ISFLRPVDVQM--REFEVLKKLNH-KNI 69 Query: 95 ITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT------LTDYDIRFYMYEILKALDYCH 148 + L I ++ +R L+ E + + L + + + +++ +++ Sbjct: 70 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 129 Query: 149 SMGIMHRDVKPHNVM--IDHEHRKL-RLIDWGLAEFYHPGQEYNVRVASRYFKGPE---- 201 GI+HR++KP N+M I + + + +L D+G A +++ + + P+ Sbjct: 130 ENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYER 189 Query: 202 --LLVDYQ-MYDYSLDMWSLGCMLASMIFRKEPF 232 L D+Q Y ++D+WS+G PF Sbjct: 190 AVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 223 >3C1X-A nrPDB Length = 373 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 61/293 (20%), Positives = 123/293 (41%), Gaps = 31/293 (10%) Query: 11 VYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL 70 V+ D++ P E HVV + +GRG + V+ + N+ K + + Sbjct: 64 VHIDLSALNP-ELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAV 122 Query: 71 KPVKKKKIKREIK------ILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQL 124 K + + E+ I+ PN+++L I +P +V ++ + D + Sbjct: 123 KSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRS-EGSPLVVLPYMKHGDLRNF 181 Query: 125 YQTLTD----YDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA- 179 + T D+ + ++ K + + S +HRD+ N M+D E +++ D+GLA Sbjct: 182 IRNETHNPTVKDLIGFGLQVAKGMKFLASKKFVHRDLAARNCMLD-EKFTVKVADFGLAR 240 Query: 180 -----EFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFH 234 EF + ++ ++ L Q + D+WS G +L ++ R P + Sbjct: 241 DMYDKEFDSVHNKTGAKLPVKWMALESL--QTQKFTTKSDVWSFGVLLWELMTRGAPPYP 298 Query: 235 GHDNYD---QLVRIAKVLGTE----DLYDYIDKY---NIELDPRFNDILGRHS 277 + +D L++ ++L E LY+ + K E+ P F++++ R S Sbjct: 299 DVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRIS 351 >3G0E-A nrPDB Length = 336 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 60/263 (22%), Positives = 104/263 (39%), Gaps = 53/263 (20%) Query: 11 VYTDVNTHRPREY-WDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEA-----INITNNEK 64 VY D T P ++ W++ + + +G + LG G + +V EA I Sbjct: 28 VYID-PTQLPYDHKWEFPRNRLSFG--------KTLGAGAFGKVVEATAYGLIKSDAAMT 78 Query: 65 VVVKILKP----VKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTD 120 V VK+LKP +++ + E+K+L L NI+ L + ++ E+ D Sbjct: 79 VAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACT--IGGPTLVITEYCCYGD 136 Query: 121 FKQLYQTLTDYDI---------------------RFYMYEILKALDYCHSMGIMHRDVKP 159 + D I + Y++ K + + S +HRD+ Sbjct: 137 LLNFLRRKRDSFICSKTSPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAA 196 Query: 160 HNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLVDYQMYDYSLDMW 216 N+++ H R ++ D+GLA Y V+ +R + PE + + +Y + D+W Sbjct: 197 RNILLTH-GRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFN-CVYTFESDVW 254 Query: 217 SLGCMLASMIFRKEPFFHGHDNY 239 S G IF E F G Y Sbjct: 255 SYG------IFLWELFSLGSSPY 271 >4EUT-A nrPDB Length = 396 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 48/214 (22%), Positives = 93/214 (43%), Gaps = 33/214 (15%) Query: 45 LGRGKYSEVFE----------AINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNI 94 LG+G + VF AI + NN + L+PV + RE ++L+ L NI Sbjct: 17 LGQGATANVFRGRHKKTGDLFAIKVFNN----ISFLRPVDVQM--REFEVLKKLNH-KNI 69 Query: 95 ITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT------LTDYDIRFYMYEILKALDYCH 148 + L I ++ +R L+ E + + L + + + +++ +++ Sbjct: 70 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 129 Query: 149 SMGIMHRDVKPHNVM--IDHEHRKL-RLIDWGLAEFYHPGQEYNVRVASRYFKGPE---- 201 GI+HR++KP N+M I + + + +L D+G A +++ + + P+ Sbjct: 130 ENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYER 189 Query: 202 --LLVDYQ-MYDYSLDMWSLGCMLASMIFRKEPF 232 L D+Q Y ++D+WS+G PF Sbjct: 190 AVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 223 >4OTD-A nrPDB Length = 341 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 72/307 (23%), Positives = 125/307 (40%), Gaps = 58/307 (18%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP--------VKKKKIKREIKILENL 88 +D++ + LGRG + +V + + E +K LK V+ ++ I Sbjct: 12 EDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTS 71 Query: 89 RGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIR--FYMYEILKALDY 146 G P ++ L + P V E+ D + + R FY ++ L + Sbjct: 72 AGHPFLVNLFGCFQTP--EHVCFVMEYSAGGDLMLHIHSDVFSEPRAIFYSACVVLGLQF 129 Query: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLVD 205 H I++RD+K N+++D E +++ D+GL E G + + F PE+L D Sbjct: 130 LHEHKIVYRDLKLDNLLLDTEG-YVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTD 188 Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIEL 265 Y ++D W LG +L M+ + P F G D E+++D I Sbjct: 189 TS-YTRAVDWWGLGVLLYEMLVGESP-FPGDDE-------------EEVFDSI------- 226 Query: 266 DPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTARE-----AME 320 ND R+ RF +S EA+ + +LLR + + RL + E + Sbjct: 227 ---VND------EVRYPRF--------LSAEAIGIMRRLLRRNPERRLGSSERDAEDVKK 269 Query: 321 HPYFYTV 327 P+F T+ Sbjct: 270 QPFFRTL 276 >5M07-A nrPDB Length = 276 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 37/156 (23%), Positives = 70/156 (44%), Gaps = 17/156 (10%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK------KKKIKREIKILENLRGGP 92 Y +VR LG EV+ + +K+L P +++ +RE ++ L P Sbjct: 32 YTVVRMLGASAMGEVYLVQHPGFPGWQALKVLSPAMAADDEFRRRFQRETEVAARLFH-P 90 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNTDFKQ-----LYQTLTDYDIRFYMYEILKALDYC 147 +I+ + D + + ++V+ D Q L ++ + + ALDY Sbjct: 91 HILEVHD--RGEFDGQLWIAMDYVDGIDATQHMADRFPAVLPVGEVLAIVTAVAGALDYA 148 Query: 148 HSMGIMHRDVKPHNVMIDHEH---RKLRLIDWGLAE 180 H G++HRDV P NV++ + +++ L D+G+A Sbjct: 149 HQRGLLHRDVNPANVVLTSQSAGDQRILLADFGIAS 184 >5AMN-A nrPDB Length = 299 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 28/104 (26%), Positives = 54/104 (51%), Gaps = 5/104 (4%) Query: 126 QTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPG 185 + LT D+ + ++I + + Y M ++HRD+ N+++ E RK+++ D+GL+ + Sbjct: 131 RALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILV-AEGRKMKISDFGLSRDVYEE 189 Query: 186 QEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMI 226 Y R R + E L D+ +Y D+WS G +L ++ Sbjct: 190 DSYVKRSQGRIPVKWMAIESLFDH-IYTTQSDVWSFGVLLWEIV 232 >4GS6-A nrPDB Length = 315 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 49/200 (24%), Positives = 86/200 (43%), Gaps = 24/200 (12%) Query: 45 LGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDP 104 +GRG + V +A + + +I ++K E++ L + PNI+ L +P Sbjct: 17 VGRGAFGVVCKA-KWRAKDVAIKQIESESERKAFIVELRQLSRVNH-PNIVKLYGACLNP 74 Query: 105 VSRTPALVFEHVNNTDFKQLYQTL---------TDYDIRFYMYEILKALDYCHSM---GI 152 V LV E+ LY L T + + + + Y HSM + Sbjct: 75 V----CLVMEYAEGGS---LYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKAL 127 Query: 153 MHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYS 212 +HRD+KP N+++ L++ D+G A N A+ + PE+ + Y Sbjct: 128 IHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNKGSAA--WMAPEVF-EGSNYSEK 184 Query: 213 LDMWSLGCMLASMIFRKEPF 232 D++S G +L +I R++PF Sbjct: 185 CDVFSWGIILWEVITRRKPF 204 >4R7H-A nrPDB Length = 343 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 53/226 (23%), Positives = 92/226 (40%), Gaps = 44/226 (19%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNE-----KVVVKILKPV----KKKKIKREIKILE 86 +++ Q + LG G + +V EA + KV VK+LK +K+ + E+KI+ Sbjct: 49 RNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMS 108 Query: 87 NLRGGPNIITLADIVKDPVSRTPALVF-EHVNNTDF------------------------ 121 +L NI+ L P LV E+ D Sbjct: 109 HLGQHENIVNLLGAC---THGGPVLVITEYCTYGDLLNFLRRKAEAMLGPSLSPGQDPEG 165 Query: 122 --KQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA 179 K+ + L D+ + ++ + + + S +HRDV NV++ + H ++ D+GLA Sbjct: 166 LDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVA-KIGDFGLA 224 Query: 180 EFYHPGQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCML 222 Y V+ +R + PE + D +Y D+WS G +L Sbjct: 225 RDIMNDSNYIVKGNARLPVKWMAPESIFD-SVYTVQSDVWSYGILL 269 >4JLC-A nrPDB Length = 657 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 46/201 (22%), Positives = 91/201 (45%), Gaps = 33/201 (16%) Query: 45 LGRGKYSEVFE----------AINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNI 94 LG+G + VF A+ + NN + L+PV + RE ++L+ L NI Sbjct: 16 LGQGATANVFRGRHKKTGDLYAVKVFNN----ISFLRPVDVQM--REFEVLKKL-NHKNI 68 Query: 95 ITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT------LTDYDIRFYMYEILKALDYCH 148 + L I ++ +R L+ E + + L + + + +++ +++ Sbjct: 69 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 128 Query: 149 SMGIMHRDVKPHNVM--IDHEHRKL-RLIDWGLAEFYHPGQEYNVRVASRYFKGPE---- 201 GI+HRD+KP N+M I + + + +L D+G A +++ + + P+ Sbjct: 129 ENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYER 188 Query: 202 --LLVDYQ-MYDYSLDMWSLG 219 L D+Q Y ++D+WS+G Sbjct: 189 AVLRKDHQKKYGATVDLWSVG 209 >5FM2-A nrPDB Length = 355 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 28/104 (26%), Positives = 54/104 (51%), Gaps = 5/104 (4%) Query: 126 QTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPG 185 + LT D+ + ++I + + Y M ++HRD+ N+++ E RK+++ D+GL+ + Sbjct: 186 RALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILV-AEGRKMKISDFGLSRDVYEE 244 Query: 186 QEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMI 226 Y R R + E L D+ +Y D+WS G +L ++ Sbjct: 245 DSYVKRSQGRIPVKWMAIESLFDH-IYTTQSDVWSFGVLLWEIV 287 >1AD5-A nrPDB Length = 438 Score = 45.8 bits (107), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 45/222 (20%), Positives = 101/222 (45%), Gaps = 35/222 (15%) Query: 17 THRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP--VK 74 + +P++ W+ ++ + ++ +L +KLG G++ EV+ A + KV VK +KP + Sbjct: 165 SSKPQKPWEKDAWEIP---RESLKLEKKLGAGQFGEVWMA-TYNKHTKVAVKTMKPGSMS 220 Query: 75 KKKIKREIKILENLRGGPNIITLADIVKDPV-------SRTPALVFEHVNNTDFKQLYQT 127 + E +++ L+ + A + K+P+ ++ L F + KQ Sbjct: 221 VEAFLAEANVMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGS-KQPLPK 279 Query: 128 LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE 187 L D+ +I + + + +HRD++ N+++ ++ D+GLA Sbjct: 280 LIDFSA-----QIAEGMAFIEQRNYIHRDLRAANILVS-ASLVCKIADFGLA-------- 325 Query: 188 YNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMI 226 RV +++ + PE +++ + D+WS G +L ++ Sbjct: 326 ---RVGAKFPIKWTAPE-AINFGSFTIKSDVWSFGILLMEIV 363 >6NT9-A nrPDB Length = 742 Score = 45.4 bits (106), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 51/219 (23%), Positives = 97/219 (44%), Gaps = 40/219 (18%) Query: 45 LGRGKYSEVFE----------AINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNI 94 LG+G + VF AI + NN + L+PV + RE ++L+ L NI Sbjct: 15 LGQGATANVFRGRHKKTGDLFAIKVFNN----ISFLRPVDVQM--REFEVLKKL-NHKNI 67 Query: 95 ITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT------LTDYDIRFYMYEILKALDYCH 148 + L I ++ +R L+ E + + L + + + +++ +++ Sbjct: 68 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 127 Query: 149 SMGIMHRDVKPHNVM--IDHEHRKL-RLIDWGLAEFYHPGQEYNVRVASRYFKGPE---- 201 GI+HR++KP N+M I + + + +L D+G A +++ + + P+ Sbjct: 128 ENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYER 187 Query: 202 --LLVDYQ-MYDYSLDMWSLGCML-----ASMIFRKEPF 232 L D+Q Y ++D+WS+G S+ FR PF Sbjct: 188 AVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFR--PF 224 >2H34-A nrPDB Length = 309 Score = 45.4 bits (106), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 48/205 (23%), Positives = 93/205 (45%), Gaps = 16/205 (7%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILK------PVKKKKIKREIKILENLRGGP 92 Y+L R +GRG +V+EA + V +K++ PV + +++RE + L+ P Sbjct: 36 YRLRRLVGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPVFRTRMQREARTAGRLQE-P 94 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYCHS 149 +++ + D + + + +N D + + L + +I ALD H+ Sbjct: 95 HVVPIHDFGE--IDGQLYVDMRLINGVDLAAMLRRQGPLAPPRAVAIVRQIGSALDAAHA 152 Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ--EYNVRVASRYFKGPELLVDYQ 207 G HRDVKP N+++ + L+D+G+A + + V + Y+ PE + Sbjct: 153 AGATHRDVKPENILVSADDFAY-LVDFGIASATTDEKLTQLGNTVGTLYYMAPERFSESH 211 Query: 208 MYDYSLDMWSLGCMLASMIFRKEPF 232 Y D+++L C+L + P+ Sbjct: 212 AT-YRADIYALTCVLYECLTGSPPY 235 >4RT7-A nrPDB Length = 415 Score = 45.4 bits (106), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 28/99 (28%), Positives = 50/99 (50%), Gaps = 5/99 (5%) Query: 127 TLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ 186 LT D+ + Y++ K +++ +HRD+ NV++ H + +++ D+GLA Sbjct: 239 VLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTH-GKVVKICDFGLARDIMSDS 297 Query: 187 EYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCML 222 Y VR +R + PE L + +Y D+WS G +L Sbjct: 298 NYVVRGNARLPVKWMAPESLFE-GIYTIKSDVWSYGILL 335 >3MDY-A nrPDB Length = 337 Score = 45.4 bits (106), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 55/207 (26%), Positives = 95/207 (45%), Gaps = 28/207 (13%) Query: 40 QLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILEN-LRGGPNIIT-L 97 Q+V+++G+G+Y EV+ + EKV VK+ ++ RE +I + L NI+ + Sbjct: 40 QMVKQIGKGRYGEVW--MGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFI 97 Query: 98 ADIVKDPVSRTPALVFE--HVNNTDFKQLYQTLTDYDIRFYM-YEILKALDYCHSM---- 150 A +K S T + H N + + L T D + Y + L + H+ Sbjct: 98 AADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEIFST 157 Query: 151 ----GIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEY----NVRVASRYFKGPE 201 I HRD+K N+++ ++ + D GLA +F E N RV ++ + PE Sbjct: 158 QGKPAIAHRDLKSKNILV-KKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPE 216 Query: 202 LLVD------YQMYDYSLDMWSLGCML 222 +L + +Q Y + DM+S G +L Sbjct: 217 VLDESLNRNHFQSYIMA-DMYSFGLIL 242 >1CSN-A nrPDB Length = 298 Score = 45.4 bits (106), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 37/160 (23%), Positives = 73/160 (45%), Gaps = 26/160 (16%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIK-----REIKILENLRGGPN 93 Y++ R++G G + +FE N+ NN++V +K +P + + R K+L G PN Sbjct: 12 YKVGRRIGEGSFGVIFEGTNLLNNQQVAIK-FEPRRSDAPQLRDEYRTYKLLAGCTGIPN 70 Query: 94 IITLAD------IVKDPVSRTPALVFEHVNNTDFKQLY-QTLTDYDIRFYMYEILKALDY 146 + +V D + P+L D L + + + ++L + Sbjct: 71 VYYFGQEGLHNVLVIDLLG--PSL-------EDLLDLCGRKFSVKTVAMAAKQMLARVQS 121 Query: 147 CHSMGIMHRDVKPHNVMIDHEHRK----LRLIDWGLAEFY 182 H +++RD+KP N +I + K + ++D+G+ +FY Sbjct: 122 IHEKSLVYRDIKPDNFLIGRPNSKNANMIYVVDFGMVKFY 161 >4NT4-A nrPDB Length = 312 Score = 45.1 bits (105), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 41/158 (25%), Positives = 76/158 (48%), Gaps = 14/158 (8%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIK-----REIKIL-ENLRGG 91 ++++ +K+G G + E+ N+ NNE V +K ++P+K K + R K+L + Sbjct: 13 NFRVGKKIGCGNFGELRLGKNLYNNEHVAIK-MEPMKSKAPQLHLEYRFYKLLGSHADNA 71 Query: 92 PNIITLADIVKDPVSRTPALVFEHVN---NTDFKQLYQTLTDYDIRFYMYEILKALDYCH 148 P+ I + R A+V E + F + + + ++L ++Y H Sbjct: 72 PDGIPRIYHLGTCGGRYNAMVLELLGLSLEDLFNICARKFSLKTVLMIAKQLLHRIEYVH 131 Query: 149 SMGIMHRDVKPHNVMIDHEHRK----LRLIDWGLAEFY 182 S +++RDVKP N +I K + +ID+GLA+ Y Sbjct: 132 SRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEY 169 >5CEK-A nrPDB Length = 263 Score = 45.1 bits (105), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 68/288 (23%), Positives = 121/288 (42%), Gaps = 60/288 (20%) Query: 53 VFEAINITNNEKVVVKILKPVK--KKKIKREIKILENLRGGPNIITLADIVKDPVSRTPA 110 V A+ I ++ K+ P+K + KI+ I++ P+ + IV+ + T A Sbjct: 25 VSRALCIHTGRELRCKVF-PIKHYQDKIRPYIQL-------PSHSNITGIVEVILGETKA 76 Query: 111 LVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHE 167 VF + D ++ L + + +I+ A+ +CH I+ D+K + E Sbjct: 77 YVFFEKDFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTE 136 Query: 168 HR-KLRLIDWGLAEFYHPGQEYNVRVASRY----FKGPELLVDYQMYD-YSLDMWSLGCM 221 R +LRL E H + + ++ ++ + PE+L Y + D+WSLG M Sbjct: 137 ERTQLRLESL---EDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVM 193 Query: 222 LASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRW 281 L +++ + PF HD+ DP S+ R Sbjct: 194 LYTLLVGRYPF---HDS---------------------------DPS-----ALFSKIRR 218 Query: 282 ERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 329 +F E+ +SP+A + LLR + RLTA E + HP+F +V++ Sbjct: 219 GQFCIPEH---ISPKARCLIRSLLRREPSERLTAPEILLHPWFESVLE 263 >6O8B-A nrPDB Length = 665 Score = 45.1 bits (105), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 46/201 (22%), Positives = 91/201 (45%), Gaps = 33/201 (16%) Query: 45 LGRGKYSEVFE----------AINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNI 94 LG+G + VF AI + NN + L+PV + RE ++L+ L NI Sbjct: 23 LGQGATANVFRGRHKKTGDLFAIKVFNN----ISFLRPVDVQM--REFEVLKKL-NHKNI 75 Query: 95 ITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT------LTDYDIRFYMYEILKALDYCH 148 + L I ++ +R L+ E + + L + + + +++ +++ Sbjct: 76 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 135 Query: 149 SMGIMHRDVKPHNVM--IDHEHRKL-RLIDWGLAEFYHPGQEYNVRVASRYFKGPE---- 201 GI+HR++KP N+M I + + + +L D+G A +++ + + P+ Sbjct: 136 ENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVELYGTEEYLHPDMYER 195 Query: 202 --LLVDYQ-MYDYSLDMWSLG 219 L D+Q Y ++D+WS+G Sbjct: 196 AVLRKDHQKKYGATVDLWSIG 216 >2RIO-A nrPDB Length = 434 Score = 45.1 bits (105), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 47/213 (22%), Positives = 89/213 (41%), Gaps = 57/213 (26%) Query: 137 MYEILKALDYCHSMGIMHRDVKPHNVMIDHEHR----------KLRLI--DWGLAEFYHP 184 + +I + + HS+ I+HRD+KP N+++ R LR++ D+GL + Sbjct: 121 LRQIASGVAHLHSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDS 180 Query: 185 GQE-----YNVRVASRYFKGPELLVDY------QMYDYSLDMWSLGCMLASMIFR-KEPF 232 GQ N + ++ PELL + + S+D++S+GC+ ++ + K PF Sbjct: 181 GQSSFRTNLNNPSGTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPF 240 Query: 233 FHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHL 292 D Y + I + + + D ++ H R Sbjct: 241 ---GDKYSRESNIIRGIFSLD-----------------EMKCLHDRS------------- 267 Query: 293 VSPEALDFLDKLLRYDHQSRLTAREAMEHPYFY 325 + EA D + +++ +D R TA + + HP F+ Sbjct: 268 LIAEATDLISQMIDHDPLKRPTAMKVLRHPLFW 300 >2PSQ-A nrPDB Length = 370 Score = 45.1 bits (105), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 53/225 (23%), Positives = 103/225 (45%), Gaps = 47/225 (20%) Query: 36 QDDYQLVRKLGRGKYSEVF--EAINITNNE-----KVVVKILKPVKKKK----IKREIKI 84 +D L + LG G + +V EA+ I ++ V VK+LK +K + E+++ Sbjct: 80 RDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEM 139 Query: 85 LENLRGGPNIITL--ADIVKDPV------------------SRTPALVFEH-VNNTDFKQ 123 ++ + NII L A P+ R P + + + +N +Q Sbjct: 140 MKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQ 199 Query: 124 LYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA---- 179 + T D+ Y++ + ++Y S +HRD+ NV++ E+ +++ D+GLA Sbjct: 200 M----TFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLV-TENNVMKIADFGLARDIN 254 Query: 180 --EFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCML 222 ++Y + N R+ ++ PE L D ++Y + D+WS G ++ Sbjct: 255 NIDYYK--KTTNGRLPVKWM-APEALFD-RVYTHQSDVWSFGVLM 295 >4NEU-A nrPDB Length = 333 Score = 44.7 bits (104), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 29/111 (26%), Positives = 55/111 (49%), Gaps = 16/111 (14%) Query: 137 MYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH----PGQEYN--- 189 + EI++ + Y H G++H+D+KP N+++D++ +++ D GLA F +E+N Sbjct: 128 ILEIIEGMCYLHGKGVIHKDLKPENILVDNDFH-IKIADLGLASFKMWSKLNNEEHNELR 186 Query: 190 -------VRVASRYFKGPELLVDYQMY-DYSLDMWSLGCMLASMIFRKEPF 232 + Y+ PE L D D++S +L ++ KEP+ Sbjct: 187 EVDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPY 237 >5WNL-A nrPDB Length = 342 Score = 44.7 bits (104), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 40/203 (19%), Positives = 101/203 (49%), Gaps = 20/203 (9%) Query: 44 KLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPN-----IITLA 98 K+G G + +V++ ++ + +K P + +++LE + I+ + Sbjct: 27 KVGSGGFGQVYKVRHVHWKTWLAIKC-SPSLHVDDRERMELLEEAKKMEMAKFRYILPVY 85 Query: 99 DIVKDPVSRTPALVFEHVNNTDFKQLYQTL-TDYDIRF-YMYEILKALDYCHSMG--IMH 154 I ++PV LV E++ ++L + +D+RF ++E +++ H M ++H Sbjct: 86 GICQEPV----GLVMEYMETGSLEKLLASEPLPWDLRFRIVHETAVGMNFLHCMSPPLLH 141 Query: 155 RDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY----FKGPELLVD-YQMY 209 ++KP N+++D H +++ D+GLA+ +++ + + + PE + + +++ Sbjct: 142 LNLKPANILLD-AHYHVKISDFGLAKCNGMSHSHDLSMDGLFGTIAYLPPERIREKSRLF 200 Query: 210 DYSLDMWSLGCMLASMIFRKEPF 232 D D++S ++ ++ +K+PF Sbjct: 201 DTKHDVYSFAIVIWGVLTQKKPF 223 >5EG3-A nrPDB Length = 334 Score = 44.7 bits (104), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 53/225 (23%), Positives = 101/225 (44%), Gaps = 47/225 (20%) Query: 36 QDDYQLVRKLGRGKYSEVF--EAINITNNE-----KVVVKILKPVKKKK----IKREIKI 84 +D L + LG G + +V EA+ I ++ V VK+LK +K + E+++ Sbjct: 34 RDKLTLGKPLGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEM 93 Query: 85 LENLRGGPNIITL--ADIVKDPV------------------SRTPALVFE-HVNNTDFKQ 123 ++ + NII L A P+ R P + +N +Q Sbjct: 94 MKMIGKHKNIINLLGACTQDGPLYVIVAYASKGNLREYLRARRPPGMELSPDINRVPEEQ 153 Query: 124 LYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA---- 179 + T D+ Y++ + ++Y S +HRD+ NV++ E+ +++ D+GLA Sbjct: 154 M----TFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLV-TENNVMKIADFGLARDIN 208 Query: 180 --EFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCML 222 +F+ + N R+ ++ PE L D ++Y + D+WS G ++ Sbjct: 209 NIDFFK--ETTNGRLPVKWM-APEALFD-RVYTHQSDVWSFGVLM 249 >5L2Q-C nrPDB Length = 320 Score = 44.3 bits (103), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 23/107 (21%), Positives = 55/107 (51%), Gaps = 1/107 (0%) Query: 128 LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE-FYHPGQ 186 L++ + Y++++ ++ H I+HRD+K N++++ ++ + ++ L + G Sbjct: 150 LSERETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEGD 209 Query: 187 EYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFF 233 + S + P++L DMW+LG +L +M++ + PF+ Sbjct: 210 LLKDQRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPFY 256 >4P5Q-A nrPDB Length = 361 Score = 44.3 bits (103), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 50/208 (24%), Positives = 92/208 (44%), Gaps = 25/208 (12%) Query: 45 LGRGKYSEVFEAINITNNEK---VVVKILKPVKKKKIKREIKILENLRGG---PNIITLA 98 +G G++ EV ++K V +K LK +K +R+ ++ G PNII L Sbjct: 41 VGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIRLE 100 Query: 99 DIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYE-------ILKALDYCHSMG 151 +V S+ +V E++ N L +D +F + + I + Y MG Sbjct: 101 GVVTK--SKPVMIVTEYMENGSLDSF---LRKHDAQFTVIQLVGMLRGIASGMKYLSDMG 155 Query: 152 IMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH--PGQEYNVRVAS--RYFKGPELLVDYQ 207 +HRD+ N++I + + ++ D+GL+ P Y R + PE + Y+ Sbjct: 156 YVHRDLAARNILI-NSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIA-YR 213 Query: 208 MYDYSLDMWSLGCML-ASMIFRKEPFFH 234 + + D+WS G +L M + + P++ Sbjct: 214 KFTSASDVWSYGIVLWEVMSYGERPYWE 241 >4AT3-A nrPDB Length = 299 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 50/228 (21%), Positives = 102/228 (44%), Gaps = 37/228 (16%) Query: 41 LVRKLGRGKYSEVF--EAINITNNEKVVVKILKPVK------KKKIKREIKILENLRGGP 92 L R+LG G + +VF E N+ + ++ +K +K +K RE ++L NL+ Sbjct: 17 LKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQH-E 75 Query: 93 NIITLADIV--KDPVSRTPALVFEHVNNTDFKQLYQT----------------LTDYDIR 134 +I+ + DP+ +VFE++ + D + + LT + Sbjct: 76 HIVKFYGVCVEGDPL----IMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQML 131 Query: 135 FYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVAS 194 +I + Y S +HRD+ N ++ E+ +++ D+G++ + Y V + Sbjct: 132 HIAQQIAAGMVYLASQHFVHRDLATRNCLVG-ENLLVKIGDFGMSRDVYSTDYYRVGGHT 190 Query: 195 RY---FKGPELLVDYQMYDYSLDMWSLGCMLASMI-FRKEPFFHGHDN 238 + PE ++ Y+ + D+WSLG +L + + K+P++ +N Sbjct: 191 MLPIRWMPPESIM-YRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNN 237 >6DC0-A nrPDB Length = 292 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 68/288 (23%), Positives = 121/288 (42%), Gaps = 60/288 (20%) Query: 53 VFEAINITNNEKVVVKILKPVK--KKKIKREIKILENLRGGPNIITLADIVKDPVSRTPA 110 V A+ I ++ K+ P+K + KI+ I++ P+ + IV+ + T A Sbjct: 22 VSRALCIHTGRELRCKVF-PIKHYQDKIRPYIQL-------PSHSNITGIVEVILGETKA 73 Query: 111 LVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHE 167 VF + D ++ L + + +I+ A+ +CH I+ D+K + E Sbjct: 74 YVFFEKDFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTE 133 Query: 168 HR-KLRLIDWGLAEFYHPGQEYNVRVASRY----FKGPELLVDYQMYD-YSLDMWSLGCM 221 R +LRL E H + + ++ ++ + PE+L Y + D+WSLG M Sbjct: 134 ERTQLRLESL---EDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVM 190 Query: 222 LASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRW 281 L +++ + PF HD+ DP S+ R Sbjct: 191 LYTLLVGRYPF---HDS---------------------------DPS-----ALFSKIRR 215 Query: 282 ERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 329 +F E+ +SP+A + LLR + RLTA E + HP+F +V++ Sbjct: 216 GQFCIPEH---ISPKARCLIRSLLRREPSERLTAPEILLHPWFESVLE 260 >2VWV-A nrPDB Length = 302 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 67/324 (20%), Positives = 126/324 (38%), Gaps = 46/324 (14%) Query: 25 DYESHVVEWGNQDDYQLVR---KLGRGKYSEVFEAINITNNEK---VVVKILKPVKKKKI 78 D V E+ + D V+ +G G++ EV +K V +K LK ++ Sbjct: 1 DPNEAVREFAKEIDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQ 60 Query: 79 KREIKILENLRGG---PNIITLADIVKDPVSRTPALVF-EHVNNTDFKQLYQ----TLTD 130 +RE ++ G PNII L +V + + P ++ E + N + T Sbjct: 61 RREFLSEASIMGQFEHPNIIRLEGVVTNSM---PVMILTEFMENGALDSFLRLNDGQFTV 117 Query: 131 YDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNV 190 + + I + Y M +HRD+ N++++ + ++ D+GL+ F Sbjct: 118 IQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNS-NLVCKVSDFGLSRFLEENSSDPT 176 Query: 191 RVASRYFK------GPELLVDYQMYDYSLDMWSLG-CMLASMIFRKEPFFHGHDNYDQLV 243 +S K PE + ++ + + D WS G M M F + P++ Sbjct: 177 ETSSLGGKIPIRWTAPEAIA-FRKFTSASDAWSYGIVMWEVMSFGERPYWD--------- 226 Query: 244 RIAKVLGTEDLYDYIDK-YNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLD 302 + +D+ + I++ Y + P L + W++ N P+ + LD Sbjct: 227 -----MSNQDVINAIEQDYRLPPPPDCPTSLHQLMLDCWQK---DRNARPRFPQVVSALD 278 Query: 303 KLLRYDHQSRLTARE--AMEHPYF 324 K++R ++ ARE HP Sbjct: 279 KMIRNPASLKIVARENGGASHPLL 302 >5AR8-A nrPDB Length = 326 Score = 43.5 bits (101), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 42/154 (27%), Positives = 78/154 (50%), Gaps = 18/154 (11%) Query: 42 VRKLGRGKYSEVFEAINITNNEKVVVK---ILKPV---KKKKIKREIKILENLRGGPNII 95 +R L RG V A + +V VK I P+ ++K + RE +IL R I+ Sbjct: 37 LRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFS-YIL 95 Query: 96 TLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYD-----IRF-YMYEILKALDYCHS 149 + I +P +V E++ N +L T+Y +RF ++EI ++Y H+ Sbjct: 96 PILGICNEP--EFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHN 153 Query: 150 MG--IMHRDVKPHNVMIDHEHRKLRLIDWGLAEF 181 M ++H D+K N+++D+E +++ D+GL+++ Sbjct: 154 MTPPLLHHDLKTQNILLDNEFH-VKIADFGLSKW 186 >3QUP-A nrPDB Length = 323 Score = 43.5 bits (101), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 54/234 (23%), Positives = 94/234 (40%), Gaps = 37/234 (15%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGG---- 91 + + L R LG+G++ V EA + + VK+ + K I I E LR Sbjct: 22 EQQFTLGRMLGKGEFGSVREA-QLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMK 80 Query: 92 ----PNIITLADI---------VKDPVSRTPA---------LVFEHVNNTDFKQLYQTLT 129 P++ L + + P+ P L+ + F QTL Sbjct: 81 EFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTL- 139 Query: 130 DYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYN 189 +RF M +I ++Y S +HRD+ N M+ E + + D+GL+ + G Y Sbjct: 140 ---VRF-MVDIACGMEYLSSRNFIHRDLAARNCML-AEDMTVCVADFGLSRKIYSGDYYR 194 Query: 190 VRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYD 240 AS+ + E L D +Y D+W+ G + ++ R + + G +N + Sbjct: 195 QGCASKLPVKWLALESLAD-NLYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAE 247 >4CRS-A nrPDB Length = 341 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 74/308 (24%), Positives = 124/308 (40%), Gaps = 62/308 (20%) Query: 35 NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNI 94 N D++ L RG + +V A NE +K LK K + R+ +++L I Sbjct: 10 NLQDFRCCAVLLRGHFGKVLLAEYKNTNEMFAIKALK--KGDIVARD--EVDSLMCEKRI 65 Query: 95 ITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIR------------FYMYEILK 142 + V+ P F+ + F Y D + FY ++ Sbjct: 66 FETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTDVFSEPRAVFYAACVVL 125 Query: 143 ALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPE 201 L Y H I++RD+K N+++D E +++ D+GL E G + + F PE Sbjct: 126 GLQYLHEHKIVYRDLKLDNLLLDTEGF-VKIADFGLCKEGMGYGDRTSTFCGTPEFLAPE 184 Query: 202 LLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKY 261 +L + Y ++D W LG ++ M+ + P F G D E+++D I Sbjct: 185 VLTETS-YTRAVDWWGLGVLIYEMLVGESP-FPGDDE-------------EEVFDSI--- 226 Query: 262 NIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTARE---- 317 ND + R+ RF +S EA+ + +LLR + + RL A E Sbjct: 227 -------VNDEV------RYPRF--------LSTEAISIMRRLLRRNPERRLGASEKDAE 265 Query: 318 -AMEHPYF 324 +HP+F Sbjct: 266 DVKKHPFF 273 >5U6B-A nrPDB Length = 307 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 55/244 (22%), Positives = 102/244 (41%), Gaps = 37/244 (15%) Query: 41 LVRKLGRGKYSEVFEAINITNNE--KVVVKILKPVKKKKIKREIKILENLRGG----PNI 94 L + LG G++ V E ++ KV VK +K + + E + E + PN+ Sbjct: 27 LGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNV 86 Query: 95 ITLADIVKDPVSR----TPALVFEHVNNTDFKQ--LYQTLTDYDIRF-------YMYEIL 141 + L + R P ++ + + D LY L D + +M +I Sbjct: 87 MRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIA 146 Query: 142 KALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEY-NVRVASRYFK-- 198 ++Y + +HRD+ N M+ +E+ + + D+GL++ + G Y R+A K Sbjct: 147 SGMEYLSTKRFIHRDLAARNCML-NENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWI 205 Query: 199 GPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYI 258 E L D ++Y D+WS G + + R + + G +N ++YDY+ Sbjct: 206 AIESLAD-RVYTSKSDVWSFGVTMWEIATRGQTPYPGVEN-------------SEIYDYL 251 Query: 259 DKYN 262 + N Sbjct: 252 RQGN 255 >2WTK-B nrPDB Length = 373 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 33/115 (28%), Positives = 56/115 (48%), Gaps = 12/115 (10%) Query: 128 LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHR--------KLRLIDWGLA 179 + + I + + +LKALDY H MG +HR VK +++I + + L +I G Sbjct: 109 MNELAIAYILQGVLKALDYIHHMGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQR 168 Query: 180 E-FYHPGQEYNVRVASRYFKGPELL-VDYQMYDYSLDMWSLGCMLASMIFRKEPF 232 + H +Y+V+V + PE+L + Q YD D++S+G + PF Sbjct: 169 QRVVHDFPKYSVKVLP--WLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPF 221 >4LRM-A nrPDB Length = 334 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 46/223 (20%), Positives = 95/223 (42%), Gaps = 37/223 (16%) Query: 35 NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKI--------LKPVKKKKIKREIKILE 86 + +++ ++ LG G + V++ + I EKV + + P K+I E ++ Sbjct: 17 KETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMA 76 Query: 87 NLR--GGPNIITLADIVKD----------PVSRTPALVFEHVNNTDFKQLYQTLTDYDIR 134 ++ G P++ L I P V EH +N + L Sbjct: 77 SVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLN-------- 128 Query: 135 FYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ-EYNV--- 190 + +I K ++Y ++HRD+ NV++ +++ D+GLA+ + EY+ Sbjct: 129 -WCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQH-VKITDFGLAKLLGAEEKEYHAEGG 186 Query: 191 RVASRYFKGPELLVDYQMYDYSLDMWSLGCMLAS-MIFRKEPF 232 +V ++ +L +++Y + D+WS G + M F +P+ Sbjct: 187 KVPIKWMALESIL--HRIYTHQSDVWSYGVTVWELMTFGSKPY 227 >4Y83-A nrPDB Length = 332 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 46/187 (24%), Positives = 89/187 (47%), Gaps = 20/187 (10%) Query: 47 RGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVS 106 RG + +V+ A +I +++ K++ PV + K +++I R NI L V Sbjct: 83 RGAFGKVYLAQDIKTKKRMACKLI-PVDQFK-PSDVEIQACFRH-ENIAELYGAVL--WG 137 Query: 107 RTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVM 163 T L E + ++ + +++I + +LK LD+ HS ++H D+KP N++ Sbjct: 138 ETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHHDIKPSNIV 197 Query: 164 IDHEHRKLRLIDWGLA-----EFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSL 218 K L+D+GL+ + Y P ++R + + PE+++ + + D++SL Sbjct: 198 F--MSTKAVLVDFGLSVQMTEDVYFPK---DLR-GTEIYMSPEVIL-CRGHSTKADIYSL 250 Query: 219 GCMLASM 225 G L M Sbjct: 251 GATLIHM 257 >3KUL-B nrPDB Length = 325 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 40/186 (21%), Positives = 87/186 (46%), Gaps = 24/186 (12%) Query: 65 VVVKILKPVKKKKIKREIKILENLRGG---PNIITLADIVKDPVSRTPALVFEHVNNTDF 121 V +K LK ++ +R+ ++ G PNII L +V R +V E++ N Sbjct: 80 VAIKALKAGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTR--GRLAMIVTEYMENGSL 137 Query: 122 KQLYQTLTDYDIRFYMYEIL-------KALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLI 174 +T +D +F + +++ + Y +G +HRD+ NV++D + ++ Sbjct: 138 DTFLRT---HDGQFTIMQLVGMLRGVGAGMRYLSDLGYVHRDLAARNVLVD-SNLVCKVS 193 Query: 175 DWGLAEFYH--PGQEYNV---RVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMI-FR 228 D+GL+ P Y ++ R+ PE + ++ + + D+WS G ++ ++ + Sbjct: 194 DFGLSRVLEDDPDAAYTTTGGKIPIRW-TAPEAIA-FRTFSSASDVWSFGVVMWEVLAYG 251 Query: 229 KEPFFH 234 + P+++ Sbjct: 252 ERPYWN 257 >4XLV-A nrPDB Length = 328 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 63/281 (22%), Positives = 120/281 (42%), Gaps = 47/281 (16%) Query: 32 EWG-NQDDYQLVRKLGRGKYSEVFE--AINITNNEKVVVKILKPVKKKKIKRE-IKILEN 87 EW +++ L+R+LG+G + V+E A +I E +K V + RE I+ L Sbjct: 33 EWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNE 92 Query: 88 ---LRGGP--NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTL-------------T 129 ++G +++ L +V + +V E + + D K ++L T Sbjct: 93 ASVMKGFTCHHVVRLLGVVSK--GQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPT 150 Query: 130 DYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGL------AEFYH 183 ++ EI + Y ++ +HRD+ N M+ H+ +++ D+G+ ++Y Sbjct: 151 LQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDF-TVKIGDFGMTRDIYETDYYR 209 Query: 184 PGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLV 243 G + + V + PE L D ++ S DMWS G +L + E + G N +Q++ Sbjct: 210 KGGKGLLPVR---WMAPESLKD-GVFTTSSDMWSFGVVLWEITSLAEQPYQGLSN-EQVL 264 Query: 244 RIAKVLG-----------TEDLYDYIDKYNIELDPRFNDIL 273 + G DL ++N + P F +I+ Sbjct: 265 KFVMDGGYLDQPDNCPERVTDLMRMCWQFNPNMRPTFLEIV 305 >4XCU-A nrPDB Length = 300 Score = 42.7 bits (99), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 27/89 (30%), Positives = 47/89 (52%), Gaps = 7/89 (7%) Query: 138 YEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEY----NVRVA 193 Y++ + + Y S +HRD+ NV++ E +++ D+GLA H Y N R+ Sbjct: 137 YQVARGMQYLESRKCIHRDLAARNVLVT-EDNVMKIADFGLARGVHHIDYYKKTSNGRLP 195 Query: 194 SRYFKGPELLVDYQMYDYSLDMWSLGCML 222 ++ PE L D ++Y + D+WS G +L Sbjct: 196 VKWM-APEALFD-RVYTHQSDVWSFGILL 222 >3HNG-A nrPDB Length = 360 Score = 42.7 bits (99), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 24/100 (24%), Positives = 54/100 (54%), Gaps = 5/100 (5%) Query: 126 QTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPG 185 + +T D+ Y +++ + +++ S +HRD+ N+++ E+ +++ D+GLA + Sbjct: 194 EPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILL-SENNVVKICDFGLARDIYKN 252 Query: 186 QEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCML 222 +Y + +R + PE + D ++Y D+WS G +L Sbjct: 253 PDYVRKGDTRLPLKWMAPESIFD-KIYSTKSDVWSYGVLL 291 >2R2P-A nrPDB Length = 295 Score = 42.4 bits (98), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 53/234 (22%), Positives = 104/234 (44%), Gaps = 24/234 (10%) Query: 20 PREYWDYESHVVEWGNQDDYQLV---RKLGRGKYSEVFEA-INITNNEK--VVVKILKPV 73 P Y D V E+ + + + R +G G++ EV + + + V +K LK Sbjct: 2 PHTYEDPNQAVHEFAKEIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVG 61 Query: 74 KKKKIKREIKILENLRGG---PNIITLADIVKDPVSRTPALVFEHVNN----TDFKQLYQ 126 +K +R+ ++ G PNII L +V S+ +V E++ N T K+ Sbjct: 62 YTEKQRRDFLGEASIMGQFDHPNIIHLEGVVTK--SKPVMIVTEYMENGSLDTFLKKNDG 119 Query: 127 TLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH--P 184 T + + I + Y MG +HRD+ N++I+ + ++ D+GL+ P Sbjct: 120 QFTVIQLVGMLRGISAGMKYLSDMGYVHRDLAARNILINS-NLVCKVSDFGLSRVLEDDP 178 Query: 185 GQEYNVR---VASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMI-FRKEPFFH 234 Y R + R+ PE + ++ + + D+WS G ++ ++ + + P++ Sbjct: 179 EAAYTTRGGKIPIRW-TAPEAIA-FRKFTSASDVWSYGIVMWEVVSYGERPYWE 230 >5X18-A nrPDB Length = 295 Score = 42.0 bits (97), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 34/151 (22%), Positives = 72/151 (47%), Gaps = 8/151 (5%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK--KIKREIKILENLRGGPNIIT 96 Y++ +K+G G + +FE N+ N V +K +P K + +++ E K + L G PNI Sbjct: 9 YKIGKKIGEGSFGVLFEGTNMINGVPVAIK-FEPRKTEAPQLRDEYKTYKILNGTPNIPY 67 Query: 97 LADIVKDPVSRTPALVFEHVNNTD-FKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHR 155 ++ + + + D F + + + +++ ++ H+ +++R Sbjct: 68 AYYFGQEGLHNILVIDLLGPSLEDLFDWCGRKFSVKTVVQVAVQMITLIEDLHAHDLIYR 127 Query: 156 DVKPHNVMIDH----EHRKLRLIDWGLAEFY 182 D+KP N +I + + LID+G+A+ Y Sbjct: 128 DIKPDNFLIGRPGQPDANNIHLIDFGMAKQY 158 >1FVR-A nrPDB Length = 327 Score = 42.0 bits (97), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 50/225 (22%), Positives = 95/225 (42%), Gaps = 38/225 (16%) Query: 30 VVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKV--VVKILKPVKKKKIKR----EIK 83 V++W +D + +G G + +V +A + ++ +K +K K R E++ Sbjct: 21 VLDW---NDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELE 77 Query: 84 ILENLRGGPNIITLADIVKDPVSRTPALVFE-HVNNTDF----------------KQLYQ 126 +L L PNII L + A+ + H N DF Sbjct: 78 VLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTAS 137 Query: 127 TLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ 186 TL+ + + ++ + +DY +HRD+ N+++ E+ ++ D+GL+ GQ Sbjct: 138 TLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVG-ENYVAKIADFGLSR----GQ 192 Query: 187 EYNV-----RVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMI 226 E V R+ R+ L +Y +Y + D+WS G +L ++ Sbjct: 193 EVYVKKTMGRLPVRWMAIESL--NYSVYTTNSDVWSYGVLLWEIV 235 >3VHK-A nrPDB Length = 368 Score = 41.6 bits (96), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 23/90 (25%), Positives = 48/90 (53%), Gaps = 5/90 (5%) Query: 136 YMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASR 195 Y +++ K +++ S +HRD+ N+++ E +++ D+GLA + +Y + +R Sbjct: 205 YSFQVAKGMEFLASRKCIHRDLAARNILLS-EKNVVKICDFGLARDIYKDPDYVRKGDAR 263 Query: 196 Y---FKGPELLVDYQMYDYSLDMWSLGCML 222 + PE + D ++Y D+WS G +L Sbjct: 264 LPLKWMAPETIFD-RVYTIQSDVWSFGVLL 292 >3QD2-B nrPDB Length = 332 Score = 41.6 bits (96), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 25/102 (24%), Positives = 53/102 (51%), Gaps = 15/102 (14%) Query: 139 EILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE----------- 187 +I +A+++ HS G+MHRD+KP N+ + +++ D+GL +E Sbjct: 172 QIAEAVEFLHSKGLMHRDLKPSNIFFTMDD-VVKVGDFGLVTAMDQDEEEQTVLTPMPAY 230 Query: 188 --YNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIF 227 + +V ++ + PE + Y + +D++SLG +L +++ Sbjct: 231 ATHTGQVGTKLYMSPE-QIHGNNYSHKVDIFSLGLILFELLY 271 Score = 32.3 bits (72), Expect = 0.34, Method: Compositional matrix adjust. Identities = 16/55 (29%), Positives = 32/55 (58%), Gaps = 4/55 (7%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL----KPVKKKKIKREIKILENL 88 D++ ++ +GRG + VFEA N ++ +K + + + ++K+ RE+K L L Sbjct: 7 DFEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKL 61 >4XHH-A nrPDB Length = 403 Score = 41.2 bits (95), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 30/151 (19%), Positives = 75/151 (49%), Gaps = 10/151 (6%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK--KIKREIKILENLRGGPNIIT 96 +++ RK+G G + +++ N+ + E+V ++ L+ ++ + ++ E ++ + L GG I Sbjct: 9 FRIGRKIGSGSFGDIYHGTNLISGEEVAIR-LESIRSRHPQLDYESRVYKYLSGGVGIPF 67 Query: 97 LADIVKDPVSRTPALVFEHVN---NTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIM 153 + ++ A+V + + F ++ + + +++ + Y H + Sbjct: 68 IRWFGRE--GEYNAMVIDLLGPSLEDLFNYCHRKFSFKTVIMLALQMICRVQYIHGRSFI 125 Query: 154 HRDVKPHNVMIDHEHR--KLRLIDWGLAEFY 182 HRD+KP N ++ R + +ID+GL++ Y Sbjct: 126 HRDIKPDNFLMGVGRRGSTVHVIDFGLSKKY 156 >3BBT-B nrPDB Length = 328 Score = 41.2 bits (95), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 61/296 (20%), Positives = 120/296 (40%), Gaps = 26/296 (8%) Query: 35 NQDDYQLVRKLGRGKYSEVFEAINITNNEKV----VVKILKPVKKKKIKREI---KILEN 87 + + + V+ LG G + V++ I + E V +KIL K E ++ Sbjct: 13 KETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMA 72 Query: 88 LRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRF-YMYEILKALDY 146 P+++ L + P + + H ++ ++ + + +I K + Y Sbjct: 73 SMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMY 132 Query: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ-EYNVRVASRYFKGPEL-LV 204 ++HRD+ NV++ + +++ D+GLA + EYN K L + Sbjct: 133 LEERRLVHRDLAARNVLVKSPNH-VKITDFGLARLLEGDEKEYNADGGKMPIKWMALECI 191 Query: 205 DYQMYDYSLDMWSLGCMLAS-MIFRKEPF--FHGHDNYDQLVRIAKV----LGTEDLYDY 257 Y+ + + D+WS G + M F +P+ + D L + ++ + T D+Y Sbjct: 192 HYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMV 251 Query: 258 IDK-YNIELD--PRFNDILGRHSR-----KRWERFVHSENQHLVSPEALDFLDKLL 305 + K + I+ D P+F ++ SR +R+ + L SP F LL Sbjct: 252 MVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLL 307 >2QLU-A nrPDB Length = 314 Score = 41.2 bits (95), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 51/213 (23%), Positives = 98/213 (46%), Gaps = 28/213 (13%) Query: 40 QLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKIL-------ENL---- 88 QL+ RG++ V++A + N+ V VKI K+ + E +I ENL Sbjct: 18 QLLEIKARGRFGCVWKAQLM--NDFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQFI 75 Query: 89 ---RGGPNI---ITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILK 142 + G N+ + L D S T L + + + +T++ + + ++ Sbjct: 76 AAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMS-RGLSYLHEDVPW 134 Query: 143 ALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ---EYNVRVASRYFKG 199 H I HRD K NV++ + + L D+GLA + PG+ + + +V +R + Sbjct: 135 CRGEGHKPSIAHRDFKSKNVLLKSDLTAV-LADFGLAVRFEPGKPPGDTHGQVGTRRYMA 193 Query: 200 PELL---VDYQMYDY-SLDMWSLGCMLASMIFR 228 PE+L +++Q + +DM+++G +L ++ R Sbjct: 194 PEVLEGAINFQRDAFLRIDMYAMGLVLWELVSR 226 >3ZZW-A nrPDB Length = 289 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 60/283 (21%), Positives = 117/283 (41%), Gaps = 51/283 (18%) Query: 40 QLVRKLGRGKYSEVFEAINI-----TNNEKVVVKILKPVKKKKIKREIKILENLRG---G 91 + + +LG ++ +V++ + V +K LK + ++ E + LR Sbjct: 12 RFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRARLQH 71 Query: 92 PNIITLADIV-KD-PVSRTPALVFEHVNNTDFKQLY-------------------QTLTD 130 PN++ L +V KD P+S ++F + ++ D + L Sbjct: 72 PNVVCLLGVVTKDQPLS----MIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEP 127 Query: 131 YDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNV 190 D + +I ++Y S ++H+D+ NV++ ++ +++ D GL + Y + Sbjct: 128 PDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLV-YDKLNVKISDLGLFREVYAADYYKL 186 Query: 191 RVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYD--QLVRI 245 S + PE ++ Y + D+WS G +L + + G+ N D +++R Sbjct: 187 LGNSLLPIRWMAPEAIM-YGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRN 245 Query: 246 AKVLGT-EDLYDYIDKYNIEL-------DPRFNDILGRHSRKR 280 +VL +D ++ IE PRF DI HSR R Sbjct: 246 RQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKDI---HSRLR 285 >4XHL-A nrPDB Length = 394 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 30/151 (19%), Positives = 73/151 (48%), Gaps = 10/151 (6%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK--KIKREIKILENLRGGPNIIT 96 +++ RK+G G + +++ N+ + E+V ++ L+ ++ + ++ E ++ L GG I Sbjct: 9 FRIGRKIGSGSFGDIYHGTNLISGEEVAIR-LESIRSRHPQLDYESRVYRYLSGGVGIPF 67 Query: 97 LADIVKDPVSRTPALVFEHVN---NTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIM 153 + ++ A+V + + F ++ + + ++ + Y H + Sbjct: 68 IRWFGRE--GEYNAMVIDLLGPSLEDLFNYCHRRFSFKTVIMLALQMFCRIQYIHGRSFI 125 Query: 154 HRDVKPHNVMIDHEHR--KLRLIDWGLAEFY 182 HRD+KP N ++ R + +ID+GL++ Y Sbjct: 126 HRDIKPDNFLMGVGRRGSTVHVIDFGLSKKY 156 >3LZB-A nrPDB Length = 327 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 45/221 (20%), Positives = 94/221 (42%), Gaps = 36/221 (16%) Query: 35 NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKI--------LKPVKKKKIKREIKILE 86 + +++ ++ LG G + V++ + I EKV + + P K+I E ++ Sbjct: 13 KETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMA 72 Query: 87 NLRGGPNIITLADIVKD----------PVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFY 136 ++ P++ L I P V EH +N + L + Sbjct: 73 SV-DNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLN---------W 122 Query: 137 MYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ-EYNV---RV 192 +I K ++Y ++HRD+ NV++ +++ D+GLA+ + EY+ +V Sbjct: 123 CVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQH-VKITDFGLAKLLGAEEKEYHAEGGKV 181 Query: 193 ASRYFKGPELLVDYQMYDYSLDMWSLGCMLAS-MIFRKEPF 232 ++ +L +++Y + D+WS G + M F +P+ Sbjct: 182 PIKWMALESIL--HRIYTHQSDVWSYGVTVWELMTFGSKPY 220 >4IX6-A nrPDB Length = 350 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 20/49 (40%), Positives = 29/49 (59%), Gaps = 1/49 (2%) Query: 137 MYEILKALDYCHSMGIMHRDVKPHNVM-IDHEHRKLRLIDWGLAEFYHP 184 M E+L +L H G++HRDVKP N++ + + L+LID G A P Sbjct: 149 MRELLGSLARLHECGVVHRDVKPANLIAAEKDGGVLKLIDLGAAALCLP 197 >5GNK-A nrPDB Length = 297 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 45/221 (20%), Positives = 94/221 (42%), Gaps = 36/221 (16%) Query: 35 NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKI--------LKPVKKKKIKREIKILE 86 + +++ ++ LG G + V++ + I EKV + + P K+I E ++ Sbjct: 17 KETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMA 76 Query: 87 NLRGGPNIITLADIVKD----------PVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFY 136 ++ P++ L I P V EH +N + L + Sbjct: 77 SV-DNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLN---------W 126 Query: 137 MYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ-EYNV---RV 192 +I K ++Y ++HRD+ NV++ +++ D+GLA+ + EY+ +V Sbjct: 127 CVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQH-VKITDFGLAKLLGAEEKEYHAEGGKV 185 Query: 193 ASRYFKGPELLVDYQMYDYSLDMWSLGCMLAS-MIFRKEPF 232 ++ +L +++Y + D+WS G + M F +P+ Sbjct: 186 PIKWMALESIL--HRIYTHQSDVWSYGVTVWELMTFGSKPY 224 >4CI6-B nrPDB Length = 643 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 23/72 (31%), Positives = 35/72 (48%), Gaps = 4/72 (5%) Query: 133 IRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRV 192 I+F + +L ++ GI+H D+KP NV+ D + +ID GL H + Sbjct: 158 IKFIAHRLLDVTNHLAKAGIVHNDIKPGNVVFDRASGEPVVIDLGL----HSRSGEQPKG 213 Query: 193 ASRYFKGPELLV 204 + FK PEL V Sbjct: 214 FTESFKAPELGV 225 >3DKO-A nrPDB Length = 318 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 51/236 (21%), Positives = 100/236 (42%), Gaps = 30/236 (12%) Query: 20 PREYWDYESHVVEWGNQDDYQLV---RKLGRGKYSEVFEA---INITNNEKVVVKILKPV 73 P Y D V ++ + D + R +G G++ EV + + V +K LK Sbjct: 23 PETYEDPNRAVHQFAKELDASCIKIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVG 82 Query: 74 KKKKIKREIKILENLRGG---PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTD 130 +K +R+ ++ G PN++ L +V + +V E + N L Sbjct: 83 YTEKQRRDFLCEASIMGQFDHPNVVHLEGVVTR--GKPVMIVIEFMENGALDAF---LRK 137 Query: 131 YDIRFYMYE-------ILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH 183 +D +F + + I + Y MG +HRD+ N++++ + ++ D+GL+ Sbjct: 138 HDGQFTVIQLVGMLRGIAAGMRYLADMGYVHRDLAARNILVN-SNLVCKVSDFGLSRVIE 196 Query: 184 --PGQEYNV---RVASRYFKGPELLVDYQMYDYSLDMWSLG-CMLASMIFRKEPFF 233 P Y ++ R+ PE + Y+ + + D+WS G M M + + P++ Sbjct: 197 DDPEAVYTTTGGKIPVRW-TAPE-AIQYRKFTSASDVWSYGIVMWEVMSYGERPYW 250 >1JPA-A nrPDB Length = 312 Score = 39.3 bits (90), Expect = 0.003, Method: Compositional matrix adjust. Identities = 49/235 (20%), Positives = 97/235 (41%), Gaps = 26/235 (11%) Query: 20 PREYWDYESHVVEWGNQDDYQLVR---KLGRGKYSEVFEA-INITNNEK--VVVKILKPV 73 P + D V E+ + D V+ +G G++ EV + + + V +K LK Sbjct: 13 PFTFEDPNEAVREFAKEIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSG 72 Query: 74 KKKKIKREIKILENLRGG---PNIITLADIVKDPVSRTPALVF-EHVNNTDFKQLYQT-- 127 +K +R+ ++ G PN+I L +V TP ++ E + N + Sbjct: 73 YTEKQRRDFLSEASIMGQFDHPNVIHLEGVV---TKSTPVMIITEFMENGSLDSFLRQND 129 Query: 128 --LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPG 185 T + + I + Y M +HRD+ N++++ + ++ D+GL+ F Sbjct: 130 GQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVN-SNLVCKVSDFGLSRFLEDD 188 Query: 186 QE---YNVRVASRY---FKGPELLVDYQMYDYSLDMWSLG-CMLASMIFRKEPFF 233 Y + + + PE + Y+ + + D+WS G M M + + P++ Sbjct: 189 TSDPTYTSALGGKIPIRWTAPE-AIQYRKFTSASDVWSYGIVMWEVMSYGERPYW 242 >4JRN-A nrPDB Length = 372 Score = 39.3 bits (90), Expect = 0.003, Method: Compositional matrix adjust. Identities = 49/237 (20%), Positives = 87/237 (36%), Gaps = 62/237 (26%) Query: 45 LGRGKYSEVFEAINITNNEKVVVKILKPVKKKK------IKREIKILENL---------- 88 LG G ++ V+EA ++ NE++ VK+ K+ ++RE N Sbjct: 76 LGSGGFATVYEATDVETNEELAVKVFMSEKEPTDETMLDLQRESSCYRNFSLAKTAKDAQ 135 Query: 89 -----------------------------RGGPNIITLADIVKDPVSRTPALVF--EHVN 117 R PN L + +S+ + VF VN Sbjct: 136 ESCRFMVPSDVVMLEGQPASTEVVIGLTTRWVPNYFLLMMRAEADMSKVISWVFGDASVN 195 Query: 118 NTDFKQLYQTLTDYDIRFYMY-EILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDW 176 ++F + +R Y+ + +K + + GI+H D+KP N ++ + R L L D+ Sbjct: 196 KSEFGLV--------VRMYLSSQAIKLVANVQAQGIVHTDIKPANFLLLKDGR-LFLGDF 246 Query: 177 GLAEFYHPGQEYNVRVASRYFKGPE--LLVDYQMYDYSLDMWSLGCMLASMIFRKEP 231 G Y + + ++ PE Y + D W LG L + ++ P Sbjct: 247 GT---YRINNSVGRAIGTPGYEPPERPFQATGITYTFPTDAWQLGITLYCIWCKERP 300 >4YFF-A nrPDB Length = 311 Score = 39.3 bits (90), Expect = 0.003, Method: Compositional matrix adjust. Identities = 37/163 (22%), Positives = 74/163 (45%), Gaps = 11/163 (6%) Query: 80 REIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTD-FKQLYQTLTDYDIR---F 135 RE+ IL L I + + DP A+V ++++ F L++ D++ Sbjct: 89 REVSILCQLNHPCVIQFVGACLNDPSQF--AIVTQYISGGSLFSLLHEQKRILDLQSKLI 146 Query: 136 YMYEILKALDYCHSMG--IMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNV--R 191 ++ K ++Y H++ I+HRD+ HN+++ +E + D+G + F E N+ + Sbjct: 147 IAVDVAKGMEYLHNLTQPIIHRDLNSHNILL-YEDGHAVVADFGESRFLQSLDEDNMTKQ 205 Query: 192 VASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFH 234 + + PE+ Y D++S L ++ + PF H Sbjct: 206 PGNLRWMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPFAH 248 >5DMZ-A nrPDB Length = 365 Score = 39.3 bits (90), Expect = 0.003, Method: Compositional matrix adjust. Identities = 47/213 (22%), Positives = 88/213 (41%), Gaps = 35/213 (16%) Query: 45 LGRGKYSEVFEAI-----NITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLAD 99 LG G +++V+EA + N +K V+K+ KP + +++E L+ + + Sbjct: 73 LGEGAFAQVYEATQGDLNDAKNKQKFVLKVQKPANPWEFYIGTQLMERLKPSMQHMFMKF 132 Query: 100 IVKDPVSRTPALVFEHVN------------NTDFKQLYQTLTDYDIRFYMYEILKALDYC 147 LV E + NT K + Q L I F M +L ++ Sbjct: 133 YSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEKVMPQGLV---ISFAM-RMLYMIEQV 188 Query: 148 HSMGIMHRDVKPHNVMI----------DHEHRKLRLIDWGLA---EFYHPGQEYNVRVAS 194 H I+H D+KP N ++ D L LID G + + + G + + + Sbjct: 189 HDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMKLFPKGTIFTAKCET 248 Query: 195 RYFKGPELLVDYQMYDYSLDMWSLGCMLASMIF 227 F+ E+L + + ++Y +D + + + M+F Sbjct: 249 SGFQCVEMLSN-KPWNYQIDYFGVAATVYCMLF 280 >3V5Q-A nrPDB Length = 297 Score = 39.3 bits (90), Expect = 0.003, Method: Compositional matrix adjust. Identities = 52/229 (22%), Positives = 97/229 (42%), Gaps = 38/229 (16%) Query: 38 DYQLVRKLGRGKYSEVF--EAINITNNEK---VVVKILKP---VKKKKIKREIKILENLR 89 D L R+LG G + +VF E N++ + V VK LK +K +RE ++L NL+ Sbjct: 16 DIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQ 75 Query: 90 GGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT-------LTDYDIR-------- 134 +I+ + D +VFE++ + D + + L D R Sbjct: 76 -HEHIVKFYGVCGD--GDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGL 132 Query: 135 ----FYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNV 190 +I + Y S +HRD+ N ++ + +++ D+G++ + Y V Sbjct: 133 SQMLHIASQIASGMVYLASQHFVHRDLATRNCLVG-ANLLVKIGDFGMSRDVYSTDYYRV 191 Query: 191 ----RVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMI-FRKEPFFH 234 + R+ P + Y+ + D+WS G +L + + K+P+F Sbjct: 192 GGHTMLPIRWM--PPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQ 238 >5VO2-A nrPDB Length = 300 Score = 38.9 bits (89), Expect = 0.003, Method: Compositional matrix adjust. Identities = 45/207 (21%), Positives = 90/207 (43%), Gaps = 46/207 (22%) Query: 45 LGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDP 104 +G G VF + + E+V VK ++ +K+ IK L L+ PNIIT K Sbjct: 20 VGSGAQGAVF--LGRFHGEEVAVKKVRDLKETDIKH----LRKLKH-PNIITF----KGV 68 Query: 105 VSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKA-------------------LD 145 ++ P Y L ++ + +YE+L+A ++ Sbjct: 69 CTQAPC--------------YCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMN 114 Query: 146 YCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVD 205 Y H I+HRD+K N++I ++ +++ D+G ++ + + PE++ + Sbjct: 115 YLHLHKIIHRDLKSPNMLITYDDV-VKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRN 173 Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPF 232 + + +D+WS G +L ++ + P+ Sbjct: 174 EPVSE-KVDIWSFGVVLWELLTGEIPY 199 >4XI2-A nrPDB Length = 446 Score = 38.9 bits (89), Expect = 0.004, Method: Compositional matrix adjust. Identities = 22/87 (25%), Positives = 48/87 (55%), Gaps = 6/87 (6%) Query: 139 EILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY-- 196 ++ +A++Y S +HRD+ N +++ + +++ D+GL+ Y EY V S++ Sbjct: 291 DVCEAMEYLESKQFLHRDLAARNCLVN-DQGVVKVSDFGLSR-YVLDDEYTSSVGSKFPV 348 Query: 197 -FKGPELLVDYQMYDYSLDMWSLGCML 222 + PE+L+ Y + D+W+ G ++ Sbjct: 349 RWSPPEVLM-YSKFSSKSDIWAFGVLM 374 >6E4F-A nrPDB Length = 290 Score = 38.9 bits (89), Expect = 0.004, Method: Compositional matrix adjust. Identities = 43/197 (21%), Positives = 91/197 (46%), Gaps = 22/197 (11%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK--PVKKKKIKREIKILENLRGGPNII 95 D +++LG G++ V + V +K++K + + + E K++ NL ++ Sbjct: 32 DLTFLKELGTGQFG-VVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNL-SHEKLV 89 Query: 96 TLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILK-------ALDYCH 148 L + R ++ E++ N L L + RF ++L+ A++Y Sbjct: 90 QLYGVCTK--QRPIFIITEYMANG---CLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLE 144 Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLVD 205 S +HRD+ N +++ + +++ D+GL+ Y EY V S++ + PE+L+ Sbjct: 145 SKQFLHRDLAARNCLVN-DQGVVKVSDFGLSR-YVLDDEYTSSVGSKFPVRWSPPEVLM- 201 Query: 206 YQMYDYSLDMWSLGCML 222 Y + D+W+ G ++ Sbjct: 202 YSKFSSKSDIWAFGVLM 218 >5MJB-A nrPDB Length = 305 Score = 38.9 bits (89), Expect = 0.004, Method: Compositional matrix adjust. Identities = 48/229 (20%), Positives = 96/229 (41%), Gaps = 24/229 (10%) Query: 25 DYESHVVEWGNQDDYQLVR---KLGRGKYSEVFEA-INITNNEK--VVVKILKPVKKKKI 78 D V E+ + D V+ +G G++ EV++ + + + V +K LK +K Sbjct: 11 DPNEAVREFAKEIDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQ 70 Query: 79 KREIKILENLRGG---PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----LTDY 131 +R+ ++ G NII L +V SR ++ E + N + T Sbjct: 71 RRDFLSEASIMGQFDHRNIIRLEGVVTK--SRPVMIITEFMENCALDSFLRQNDGQFTVI 128 Query: 132 DIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE---Y 188 + + I + Y M +HRD+ N+++ + + ++ D+GL+ + Y Sbjct: 129 QLVGMLRGIAAGMKYLSEMNYVHRDLAARNILV-NSNLVCKVSDFGLSRYLQDDTSDPTY 187 Query: 189 NVRVASRY---FKGPELLVDYQMYDYSLDMWSLG-CMLASMIFRKEPFF 233 + + + PE + Y+ + + D+WS G M M F + P++ Sbjct: 188 TSSLGGKIPVRWTAPEAIA-YRKFTSASDVWSYGIVMWEVMSFGERPYW 235 >3SOC-A nrPDB Length = 322 Score = 38.5 bits (88), Expect = 0.005, Method: Compositional matrix adjust. Identities = 27/100 (27%), Positives = 54/100 (54%), Gaps = 8/100 (8%) Query: 136 YMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ---EYNVRV 192 Y++E + L H I HRD+K NV++ + + D+GLA + G+ + + +V Sbjct: 136 YLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTAC-IADFGLALKFEAGKSAGDTHGQV 194 Query: 193 ASRYFKGPELL---VDYQMYDY-SLDMWSLGCMLASMIFR 228 +R + PE+L +++Q + +DM+++G +L + R Sbjct: 195 GTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASR 234 >1LUF-A nrPDB Length = 343 Score = 38.5 bits (88), Expect = 0.006, Method: Compositional matrix adjust. Identities = 47/260 (18%), Positives = 102/260 (39%), Gaps = 48/260 (18%) Query: 36 QDDYQLVRKLGRGKYSEVFEA-----INITNNEKVVVKILKPVK----KKKIKREIKILE 86 +++ + VR +G G + VF+A + V VK+LK + +RE ++ Sbjct: 46 RNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMA 105 Query: 87 NLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMY-------- 138 PNI+ L + V + L+FE++ D + ++++ + + + Sbjct: 106 EF-DNPNIVKLLGVCA--VGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRAR 162 Query: 139 -------------------EILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA 179 ++ + Y +HRD+ N ++ E+ +++ D+GL+ Sbjct: 163 VSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVG-ENMVVKIADFGLS 221 Query: 180 EFYHPGQEY----NVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMI-FRKEPFF- 233 + Y N + R+ P + Y Y D+W+ G +L + + +P++ Sbjct: 222 RNIYSADYYKADGNDAIPIRWM--PPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYG 279 Query: 234 HGHDNYDQLVRIAKVLGTED 253 H+ VR +L + Sbjct: 280 MAHEEVIYYVRDGNILACPE 299 >4Y93-A nrPDB Length = 446 Score = 37.4 bits (85), Expect = 0.011, Method: Compositional matrix adjust. Identities = 41/197 (20%), Positives = 89/197 (45%), Gaps = 22/197 (11%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK--PVKKKKIKREIKILENLRGGPNII 95 D +++LG G++ V + V +K++K + + + E K++ NL ++ Sbjct: 189 DLTFLKELGTGQFG-VVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNL-SHEKLV 246 Query: 96 TLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILK-------ALDYCH 148 L + R ++ E++ N L L + RF ++L+ A++Y Sbjct: 247 QLYGVCTK--QRPIFIITEYMANGC---LLNYLREMRHRFQTQQLLEMCKDVCEAMEYLE 301 Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLVD 205 S +HRD+ N +++ + +++ D+G+ Y EY S++ + PE+L+ Sbjct: 302 SKQFLHRDLAARNCLVN-DQGVVKVSDFGMTR-YVLDDEYTSSTGSKFPVKWASPEVLM- 358 Query: 206 YQMYDYSLDMWSLGCML 222 Y + D+W+ G ++ Sbjct: 359 YSKFSSKSDIWAFGVLM 375 >5U6C-A nrPDB Length = 315 Score = 37.0 bits (84), Expect = 0.014, Method: Compositional matrix adjust. Identities = 53/242 (21%), Positives = 97/242 (40%), Gaps = 29/242 (11%) Query: 41 LVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGG--------P 92 L + LG G++ V E N+ + +K+ K + +I E L P Sbjct: 40 LGKILGEGEFGSVMEG-NLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHP 98 Query: 93 NIITLADIVKDPVSR---TPALVFEHVNNTDFKQ--LYQTLTD-------YDIRFYMYEI 140 N++ L + + S+ P ++ + D LY L + +M +I Sbjct: 99 NVMRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDI 158 Query: 141 LKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEY-NVRVASRYFK- 198 ++Y + +HRD+ N M+ + + + D+GL++ + G Y R+A K Sbjct: 159 ALGMEYLSNRNFLHRDLAARNCML-RDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKW 217 Query: 199 -GPELLVDYQMYDYSLDMWSLGCMLASMIFRKE---PFFHGHDNYDQLVRIAKVLGTEDL 254 E L D ++Y D+W+ G + + R P H+ YD L+ ++ ED Sbjct: 218 IAIESLAD-RVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDC 276 Query: 255 YD 256 D Sbjct: 277 LD 278 >5L6P-A nrPDB Length = 298 Score = 37.0 bits (84), Expect = 0.017, Method: Compositional matrix adjust. Identities = 48/229 (20%), Positives = 93/229 (40%), Gaps = 24/229 (10%) Query: 25 DYESHVVEWGNQDDYQLVR---KLGRGKYSEVFEAINITNNEK---VVVKILKPVKKKKI 78 D V E+ + D V+ +G G++ EV + V +K LK ++ Sbjct: 4 DPNEAVREFAKEIDVSCVKIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQ 63 Query: 79 KREIKILENLRGG---PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ----TLTDY 131 +R+ ++ G PNII L +V SR ++ E + N + T Sbjct: 64 RRDFLSEASIMGQFDHPNIIRLEGVVTK--SRPVMILTEFMENCALDSFLRLNDGQFTVI 121 Query: 132 DIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH---PGQEY 188 + + I + Y M +HRD+ N+++ + + ++ D+GL+ F Y Sbjct: 122 QLVGMLRGIAAGMKYLSEMNYVHRDLAARNILV-NSNLVCKVSDFGLSRFLEDDPSDPTY 180 Query: 189 NVRVASRY---FKGPELLVDYQMYDYSLDMWSLG-CMLASMIFRKEPFF 233 + + + PE + Y+ + + D+WS G M M + + P++ Sbjct: 181 TSSLGGKIPIRWTAPEAIA-YRKFTSASDVWSYGIVMWEVMSYGERPYW 228 >2Y6O-A nrPDB Length = 291 Score = 36.6 bits (83), Expect = 0.017, Method: Compositional matrix adjust. Identities = 44/212 (20%), Positives = 91/212 (42%), Gaps = 25/212 (11%) Query: 40 QLVRKLGRGKYSEVFEA-INITNNEKVVV--KILKPVKKKKIKREIKILENLRGG---PN 93 ++ + +G G++ EV + + ++ V K LK K +R+ ++ G PN Sbjct: 17 KIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHPN 76 Query: 94 IITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEIL-------KALDY 146 II L +V + ++ E++ N L D RF + +++ + Y Sbjct: 77 IIHLEGVVTK--CKPVMIITEYMENGSLDAF---LRKNDGRFTVIQLVGMLRGIGSGMKY 131 Query: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH--PGQEYNVRVAS--RYFKGPEL 202 M +HRD+ N+++ + + ++ D+G++ P Y R + PE Sbjct: 132 LSDMSYVHRDLAARNILV-NSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEA 190 Query: 203 LVDYQMYDYSLDMWSLG-CMLASMIFRKEPFF 233 + Y+ + + D+WS G M M + + P++ Sbjct: 191 IA-YRKFTSASDVWSYGIVMWEVMSYGERPYW 221 >2QKW-B nrPDB Length = 321 Score = 36.6 bits (83), Expect = 0.017, Method: Compositional matrix adjust. Identities = 26/91 (28%), Positives = 49/91 (53%), Gaps = 11/91 (12%) Query: 142 KALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKG-- 199 + L Y H+ I+HRDVK N+++D E+ ++ D+G+++ G E + S KG Sbjct: 150 RGLHYLHTRAIIHRDVKSINILLD-ENFVPKITDFGISK---KGTELDQTHLSTVVKGTL 205 Query: 200 ----PELLVDYQMYDYSLDMWSLGCMLASMI 226 PE + ++ + S D++S G +L ++ Sbjct: 206 GYIDPEYFIKGRLTEKS-DVYSFGVVLFEVL 235 >2OZO-A nrPDB Length = 613 Score = 36.6 bits (83), Expect = 0.017, Method: Compositional matrix adjust. Identities = 39/204 (19%), Positives = 92/204 (45%), Gaps = 21/204 (10%) Query: 44 KLGRGKYSEVFEAINITNNEK--VVVKILKPVKKK----KIKREIKILENLRGGPNIITL 97 +LG G + V + + ++ V +K+LK +K ++ RE +I+ L P I+ L Sbjct: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQL-DNPYIVRL 401 Query: 98 ADIVKDPVSRTPALVFEHVNNTDFKQLY----QTLTDYDIRFYMYEILKALDYCHSMGIM 153 + + + LV E + + + ++ ++++ + Y + Sbjct: 402 IGVCQ---AEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFV 458 Query: 154 HRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE-YNVRVASRY---FKGPELLVDYQMY 209 HR++ NV++ + H ++ D+GL++ Y R A ++ + PE ++++ + Sbjct: 459 HRNLAARNVLLVNRHYA-KISDFGLSKALGADDSYYTARSAGKWPLKWYAPE-CINFRKF 516 Query: 210 DYSLDMWSLG-CMLASMIFRKEPF 232 D+WS G M ++ + ++P+ Sbjct: 517 SSRSDVWSYGVTMWEALSYGQKPY 540 >5WNO-A nrPDB Length = 330 Score = 36.6 bits (83), Expect = 0.017, Method: Compositional matrix adjust. Identities = 40/204 (19%), Positives = 85/204 (41%), Gaps = 12/204 (5%) Query: 40 QLVRKLGRGKYSEVFEAINITNNEK-----VVVKILKPVKKK--KIKREIKILENLRGGP 92 +L +KLG G + VF I K V +K+ + + + ++ E + LR Sbjct: 25 KLDKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTDQSQTDEMLEEATNMFRLRHDN 84 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNTDFKQLY-QTLTDYDIRFYMYEILKALDYCHSMG 151 + + + D + + N +F +L+ + L + Y Y+I + Y Sbjct: 85 LLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKENLGAREQVLYCYQIASGMQYLEKQR 144 Query: 152 IMHRDVKPHNVMIDHEHRKLRLIDWGLAEFY-HPGQEYNVRVASRYFKGPEL-LVDYQMY 209 ++HRD+ NV++ + + + D+GL++ H ++ K + + Y Sbjct: 145 VVHRDLATRNVLV-KKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIEIFSKHCY 203 Query: 210 DYSLDMWSLGCMLASMI-FRKEPF 232 ++ D+W+ G +I F + P+ Sbjct: 204 THASDVWAFGVTCWEIITFGQSPY 227 >1U59-A nrPDB Length = 287 Score = 36.6 bits (83), Expect = 0.017, Method: Compositional matrix adjust. Identities = 40/204 (19%), Positives = 92/204 (45%), Gaps = 21/204 (10%) Query: 44 KLGRGKYSEVFEAINITNNEK--VVVKILKPVKKK----KIKREIKILENLRGGPNIITL 97 +LG G + V + + ++ V +K+LK +K ++ RE +I+ L P I+ L Sbjct: 17 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQL-DNPYIVRL 75 Query: 98 ADIVKDPVSRTPALVFEHVNNTDFKQLY----QTLTDYDIRFYMYEILKALDYCHSMGIM 153 + + + LV E + + + ++ ++++ + Y + Sbjct: 76 IGVCQ---AEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFV 132 Query: 154 HRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE-YNVRVASRY---FKGPELLVDYQMY 209 HRD+ NV++ + H ++ D+GL++ Y R A ++ + PE ++++ + Sbjct: 133 HRDLAARNVLLVNRHYA-KISDFGLSKALGADDSYYTARSAGKWPLKWYAPE-CINFRKF 190 Query: 210 DYSLDMWSLGC-MLASMIFRKEPF 232 D+WS G M ++ + ++P+ Sbjct: 191 SSRSDVWSYGVTMWEALSYGQKPY 214 >2Y4I-B nrPDB Length = 319 Score = 36.6 bits (83), Expect = 0.019, Method: Compositional matrix adjust. Identities = 22/64 (34%), Positives = 34/64 (53%), Gaps = 9/64 (14%) Query: 122 KQLYQTLTDYDI-------RFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLI 174 + LY + D I R EI+K + Y H+ GI+H+D+K NV D+ K+ + Sbjct: 114 RTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYDNG--KVVIT 171 Query: 175 DWGL 178 D+GL Sbjct: 172 DFGL 175 >5CLR-A nrPDB Length = 451 Score = 36.2 bits (82), Expect = 0.024, Method: Compositional matrix adjust. Identities = 17/60 (28%), Positives = 32/60 (53%), Gaps = 7/60 (11%) Query: 118 NTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWG 177 N + K ++ L M + + H +G++HRD+KP N+M+D + + L+D+G Sbjct: 169 NVNLKHFWEVLG------IMISVCHQVKQFHELGLIHRDLKPGNIMLDAD-MQCHLVDFG 221 >1BYG-A nrPDB Length = 278 Score = 36.2 bits (82), Expect = 0.024, Method: Compositional matrix adjust. Identities = 41/195 (21%), Positives = 88/195 (45%), Gaps = 16/195 (8%) Query: 35 NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK-PVKKKKIKREIKILENLRGGPN 93 N + +L++ +G+G++ +V + KV VK +K + E ++ LR Sbjct: 19 NMKELKLLQTIGKGEFGDVM--LGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNL 76 Query: 94 IITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLT------DYDIRFYMYEILKALDYC 147 + L IV++ +V E++ ++ D ++F + ++ +A++Y Sbjct: 77 VQLLGVIVEEKGGLY--IVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSL-DVCEAMEYL 133 Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQ 207 +HRD+ NV++ E ++ D+GL + Q+ ++ ++ PE L + + Sbjct: 134 EGNNFVHRDLAARNVLVS-EDNVAKVSDFGLTKEASSTQDTG-KLPVKW-TAPEALREKK 190 Query: 208 MYDYSLDMWSLGCML 222 S D+WS G +L Sbjct: 191 FSTKS-DVWSFGILL 204 >1K9A-A nrPDB Length = 450 Score = 36.2 bits (82), Expect = 0.028, Method: Compositional matrix adjust. Identities = 41/195 (21%), Positives = 88/195 (45%), Gaps = 16/195 (8%) Query: 35 NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK-PVKKKKIKREIKILENLRGGPN 93 N + +L++ +G+G++ +V + KV VK +K + E ++ LR Sbjct: 191 NMKELKLLQTIGKGEFGDVM--LGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNL 248 Query: 94 IITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLT------DYDIRFYMYEILKALDYC 147 + L IV++ +V E++ ++ D ++F + ++ +A++Y Sbjct: 249 VQLLGVIVEEKGGLY--IVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSL-DVCEAMEYL 305 Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQ 207 +HRD+ NV++ E ++ D+GL + Q+ ++ ++ PE L + + Sbjct: 306 EGNNFVHRDLAARNVLVS-EDNVAKVSDFGLTKEASSTQDTG-KLPVKW-TAPEALREKK 362 Query: 208 MYDYSLDMWSLGCML 222 S D+WS G +L Sbjct: 363 FSTKS-DVWSFGILL 376 >4PDO-A nrPDB Length = 299 Score = 35.8 bits (81), Expect = 0.029, Method: Compositional matrix adjust. Identities = 44/210 (20%), Positives = 93/210 (44%), Gaps = 28/210 (13%) Query: 45 LGRGKYSEVFEAINITNNEK----VVVKILKPVKKKKIKREIKILENLRGG---PNIITL 97 +G G++ EV++ + T++ K V +K LK +K + + + G NII L Sbjct: 42 IGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQFSHHNIIRL 101 Query: 98 ADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYE-------ILKALDYCHSM 150 ++ + ++ E++ N + L + D F + + I + Y +M Sbjct: 102 EGVISK--YKPMMIITEYMENGALDKF---LREKDGEFSVLQLVGMLRGIAAGMKYLANM 156 Query: 151 GIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH--PGQEYNV---RVASRYFKGPELLVD 205 +HRD+ N++++ + ++ D+GL+ P Y ++ R+ PE + Sbjct: 157 NYVHRDLAARNILVN-SNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRW-TAPE-AIS 213 Query: 206 YQMYDYSLDMWSLG-CMLASMIFRKEPFFH 234 Y+ + + D+WS G M M + + P++ Sbjct: 214 YRKFTSASDVWSFGIVMWEVMTYGERPYWE 243 >3G2F-A nrPDB Length = 336 Score = 35.0 bits (79), Expect = 0.051, Method: Compositional matrix adjust. Identities = 64/318 (20%), Positives = 130/318 (40%), Gaps = 53/318 (16%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKRE-----IKILENLRGG 91 D+ +L+ +GRG+Y V++ + V VK+ ++ E + ++E+ Sbjct: 13 DNLKLLELIGRGRYGAVYKG--SLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIA 70 Query: 92 PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYM-YEILKALDYCHSM 150 I+ + D ++ + N + K L +D+ + + + + L Y H+ Sbjct: 71 RFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTE 130 Query: 151 ---------GIMHRDVKPHNVMIDHEHRKLRLIDWGLA------EFYHPGQEYNV---RV 192 I HRD+ NV++ ++ + + D+GL+ PG+E N V Sbjct: 131 LPRGDHYKPAISHRDLNSRNVLVKNDGTCV-ISDFGLSMRLTGNRLVRPGEEDNAAISEV 189 Query: 193 ASRYFKGPELLV------DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIA 246 + + PE+L D + +DM++LG + + R F G Sbjct: 190 GTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPG----------- 238 Query: 247 KVLGTEDLYDYIDKYNIELD--PRFNDILGRHSR-KRWERFVHSENQHLVSPEAL-DFLD 302 E + +Y + E+ P F D+ SR K+ +F + ++ ++ +L + ++ Sbjct: 239 -----ESVPEYQMAFQTEVGNHPTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKETIE 293 Query: 303 KLLRYDHQSRLTAREAME 320 D ++RLTA+ A E Sbjct: 294 DCWDQDAEARLTAQCAEE 311 >3BIQ-A nrPDB Length = 467 Score = 35.0 bits (79), Expect = 0.054, Method: Compositional matrix adjust. Identities = 29/121 (23%), Positives = 51/121 (42%), Gaps = 26/121 (21%) Query: 173 LIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLG------CMLASMI 226 L+DW + G+++++RV++R + Q+Y + S G C + Sbjct: 254 LLDWTYSPIIQSGKKFDLRVSARS-------TNDQLYGNGCILASCGIRYNNYCSNITRT 306 Query: 227 FRKEPFFHGHDNYDQLVRIAKVLGT-------------EDLYDYIDKYNIELDPRFNDIL 273 F +P +NYD L+ + K + T E + +YI+K EL P F + Sbjct: 307 FLIDPSEEMANNYDFLLTLQKEIVTNILKPGRTPKEVYESVIEYIEKTKPELVPNFTKNI 366 Query: 274 G 274 G Sbjct: 367 G 367 >3ZBF-A nrPDB Length = 322 Score = 34.3 bits (77), Expect = 0.089, Method: Compositional matrix adjust. Identities = 27/111 (24%), Positives = 49/111 (44%), Gaps = 8/111 (7%) Query: 139 EILKALDYCHSMGIMHRDVKPHNVMIDHEH----RKLRLIDWGLAEFYHPGQEYNVR--- 191 +I K Y M +HRD+ N ++ + R +++ D+GLA + Y R Sbjct: 152 DISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEG 211 Query: 192 VASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQL 242 + + PE L+D ++ D+WS G ++ ++ + H N D L Sbjct: 212 LLPVRWMAPESLMD-GIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVL 261 >4FL3-A nrPDB Length = 635 Score = 34.3 bits (77), Expect = 0.097, Method: Compositional matrix adjust. Identities = 38/177 (21%), Positives = 74/177 (41%), Gaps = 23/177 (12%) Query: 72 PVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---L 128 P K ++ E +++ L P I+ + I + + + LV E + Q + Sbjct: 411 PALKDELLAEANVMQQLDN-PYIVRMIGICE---AESWMLVMEMAELGPLNKYLQQNRHV 466 Query: 129 TDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA------EFY 182 D +I ++++ + Y +HRD+ NV++ +H ++ D+GL+ E Y Sbjct: 467 KDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYA-KISDFGLSKALRADENY 525 Query: 183 HPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNY 239 + Q + Y PE ++Y + D+WS G ++ E F +G Y Sbjct: 526 YKAQTHGKWPVKWY--APE-CINYYKFSSKSDVWSFGVLMW------EAFSYGQKPY 573 >5TOS-A nrPDB Length = 395 Score = 33.9 bits (76), Expect = 0.12, Method: Compositional matrix adjust. Identities = 27/98 (27%), Positives = 49/98 (50%), Gaps = 7/98 (7%) Query: 142 KALDYCHS--MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPG--QEYNVRVASRY- 196 K L + HS + +++RD+K N+++D ++ +L D+GLA G + RV Y Sbjct: 186 KGLAFLHSDPVKVIYRDIKASNILLDADYNA-KLSDFGLARDGPMGDLSYVSTRVMGTYG 244 Query: 197 FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFH 234 + PE + + S D++S G +L ++ K H Sbjct: 245 YAAPEYMSSGHLNARS-DVYSFGVLLLEILSGKRALDH 281 >4AZV-A nrPDB Length = 569 Score = 33.5 bits (75), Expect = 0.15, Method: Compositional matrix adjust. Identities = 27/103 (26%), Positives = 44/103 (42%), Gaps = 3/103 (2%) Query: 75 KKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIR 134 K ++ EIK L G + A + +++ LV E + + + D Sbjct: 285 KYELHNEIKFLTQPPAGFD--APAVLAHGENAQSGWLVMEKLPGRLLSDMLAAGEEIDRE 342 Query: 135 FYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWG 177 + +L++L G H DV+P NVM+D RLID+G Sbjct: 343 KILGSLLRSLAALEKQGFWHDDVRPWNVMVDARQHA-RLIDFG 384 >3UIM-A nrPDB Length = 326 Score = 33.5 bits (75), Expect = 0.16, Method: Compositional matrix adjust. Identities = 50/205 (24%), Positives = 92/205 (44%), Gaps = 24/205 (11%) Query: 45 LGRGKYSEVFEAINITNNEKVVVKILKPVKKK----KIKREIKILENLRGGPNIITLADI 100 LGRG + +V++ + + V VK LK + + + + E++++ ++ N++ L Sbjct: 38 LGRGGFGKVYKG-RLADGTLVAVKRLKEERTQGGELQFQTEVEMI-SMAVHRNLLRLRGF 95 Query: 101 VKDPVSRTPALVFEHVNNTDFKQLY------QTLTDYDIRFYM-YEILKALDYCHSMG-- 151 P R LV+ ++ N Q D+ R + + L Y H Sbjct: 96 CMTPTERL--LVYPYMANGSVASCLRERPESQPPLDWPKRQRIALGSARGLAYLHDHCDP 153 Query: 152 -IMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKG---PELLVDYQ 207 I+HRDVK N+++D E + + D+GLA+ ++ +V A R G PE L + Sbjct: 154 KIIHRDVKAANILLDEEFEAV-VGDFGLAKLMDY-KDTHVTTAVRGTIGHIAPEYLSTGK 211 Query: 208 MYDYSLDMWSLGCMLASMIFRKEPF 232 + + D++ G ML +I + F Sbjct: 212 SSEKT-DVFGYGVMLLELITGQRAF 235 >5C26-A nrPDB Length = 299 Score = 33.5 bits (75), Expect = 0.18, Method: Compositional matrix adjust. Identities = 38/177 (21%), Positives = 74/177 (41%), Gaps = 23/177 (12%) Query: 72 PVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---L 128 P K ++ E +++ L P I+ + I + + + LV E + Q + Sbjct: 69 PALKDELLAEANVMQQL-DNPYIVRMIGICE---AESWMLVMEMAELGPLNKYLQQNRHV 124 Query: 129 TDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA------EFY 182 D +I ++++ + Y +HRD+ NV++ +H ++ D+GL+ E Y Sbjct: 125 KDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYA-KISDFGLSKALRADENY 183 Query: 183 HPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNY 239 + Q + Y PE ++Y + D+WS G ++ E F +G Y Sbjct: 184 YKAQTHGKWPVKWY--APE-CINYYKFSSKSDVWSFGVLMW------EAFSYGQKPY 231 >4AZW-A nrPDB Length = 471 Score = 33.5 bits (75), Expect = 0.18, Method: Compositional matrix adjust. Identities = 27/104 (25%), Positives = 44/104 (42%), Gaps = 3/104 (2%) Query: 74 KKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDI 133 K ++ EIK L G + A + +++ LV E + + + D Sbjct: 284 NKHELHNEIKFLTQPPAGFD--APAVLAHGENAQSGWLVMEKLPGRLLSDMLAAGEEIDR 341 Query: 134 RFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWG 177 + +L++L G H DV+P NVM+D RLID+G Sbjct: 342 EKILGSLLRSLAALEKKGFWHDDVRPWNVMVDARQHA-RLIDFG 384 >2RSV-A nrPDB Length = 403 Score = 33.1 bits (74), Expect = 0.22, Method: Compositional matrix adjust. Identities = 16/46 (34%), Positives = 30/46 (65%), Gaps = 1/46 (2%) Query: 140 ILKALDYCHSMGIMHRDVKPHNVMIDHEH-RKLRLIDWGLAEFYHP 184 IL L+Y H +H D+K N+++++++ ++ L+D+GLA Y P Sbjct: 168 ILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCP 213 >4O1O-A nrPDB Length = 717 Score = 32.7 bits (73), Expect = 0.24, Method: Compositional matrix adjust. Identities = 22/93 (23%), Positives = 39/93 (41%), Gaps = 7/93 (7%) Query: 79 KREIKILENLRGGPNIITLADIVKDPVSRTPALVF------EHVNNTDFKQLYQTLTDYD 132 ++E+ L++ R N++T D L EH+ N + D Sbjct: 385 QQEVSCLQSSRANDNVVTFYGSESDGSCLHVCLALCEYTLQEHLANHRGDAVPNE-EDES 443 Query: 133 IRFYMYEILKALDYCHSMGIMHRDVKPHNVMID 165 R + + KA+ H G H+D++P N++ID Sbjct: 444 ARNILSSLFKAIGELHRSGYSHQDLQPQNILID 476 >5VC6-A nrPDB Length = 289 Score = 32.7 bits (73), Expect = 0.25, Method: Compositional matrix adjust. Identities = 11/37 (29%), Positives = 23/37 (62%) Query: 128 LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMI 164 + +++ + ++ + L Y HSM ++H D+KP N+ I Sbjct: 112 FKEAELKDLLLQVGRGLRYIHSMSLVHMDIKPSNIFI 148 >6G4J-A nrPDB Length = 315 Score = 32.7 bits (73), Expect = 0.25, Method: Compositional matrix adjust. Identities = 31/151 (20%), Positives = 64/151 (42%), Gaps = 8/151 (5%) Query: 32 EWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKI----LKPVKKKKIKREIKILEN 87 +W N + Y L ++LG+G V+ A T++ V +K+ L + + + ++ Sbjct: 22 KW-NGNTYTLRKQLGKGANGIVYLAE--TSDGHVALKVSDDSLSITSEVNVLKSFSKAQS 78 Query: 88 LRGGPNIITLADI-VKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDY 146 + GP+ D + ++ E++ + I M ++L +L Sbjct: 79 VTMGPSFFDTDDAYIPSANTKVSFYAMEYIKGPLLLKYVSDKGAEWIPVLMIQLLSSLSV 138 Query: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWG 177 H G + D+KP N+++ ++R ID G Sbjct: 139 LHQQGWIFGDLKPDNLIVTGPPARIRCIDVG 169 >2LAV-A nrPDB Length = 361 Score = 32.7 bits (73), Expect = 0.26, Method: Compositional matrix adjust. Identities = 16/46 (34%), Positives = 30/46 (65%), Gaps = 1/46 (2%) Query: 140 ILKALDYCHSMGIMHRDVKPHNVMIDHEH-RKLRLIDWGLAEFYHP 184 IL L+Y H +H D+K N+++++++ ++ L+D+GLA Y P Sbjct: 161 ILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCP 206 >5XD6-A nrPDB Length = 305 Score = 32.3 bits (72), Expect = 0.33, Method: Compositional matrix adjust. Identities = 43/217 (19%), Positives = 86/217 (39%), Gaps = 24/217 (11%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK--KKIKREIKILENLRGGPNI 94 D+Y +G G Y VF I + + + +K L K+ ++ ++ ++ LR + Sbjct: 22 DNYGSKSLIGEGSYGRVFYGI-LKSGKAAAIKKLDSSKQPDQEFLAQVSMVSRLRQENVV 80 Query: 95 ITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ------------TLTDYDIRFYMYEILK 142 L V P+ L +E+ N + L+ + + Sbjct: 81 ALLGYCVDGPLR---VLAYEYAPNGSLHDILHGRKGVKGAQPGPVLSWHQRVKIAVGAAR 137 Query: 143 ALDYCHSMG---IMHRDVKPHNVMI-DHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY-F 197 L+Y H ++HRD+K NV++ D + K+ D + ++ RV + + Sbjct: 138 GLEYLHEKANPHVIHRDIKSSNVLLFDDDVAKIADFDLSNQAPDMAARLHSTRVLGTFGY 197 Query: 198 KGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFH 234 PE + + S D++S G +L ++ ++P H Sbjct: 198 HAPEYAMTGTLSTKS-DVYSFGVVLLELLTGRKPVDH 233 >6BFN-A nrPDB Length = 342 Score = 32.0 bits (71), Expect = 0.54, Method: Compositional matrix adjust. Identities = 40/157 (25%), Positives = 63/157 (40%), Gaps = 28/157 (17%) Query: 44 KLGRGKYSEVFEAINITNNEKVVVKILK-------PVKKKKIKREIKILENLRGGPNIIT 96 K+G G + V+ A+ N VK LK K+ E++ L R PNI+ Sbjct: 29 KIGEGGFGCVYRAV--MRNTVYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRH-PNIVD 85 Query: 97 LADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTD----------YDIRFYMYEILKALDY 146 A + LV+ + N + T DI + +A+ + Sbjct: 86 FAGYCAQ--NGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDI---LLGTARAIQF 140 Query: 147 CH--SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF 181 H S ++H D+K NV++D E +L D+GLA F Sbjct: 141 LHQDSPSLIHGDIKSSNVLLD-ERLTPKLGDFGLARF 176 >3SXS-A nrPDB Length = 268 Score = 31.6 bits (70), Expect = 0.61, Method: Compositional matrix adjust. Identities = 19/88 (21%), Positives = 44/88 (50%), Gaps = 6/88 (6%) Query: 138 YEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY- 196 Y++ + + + S +HRD+ N ++D + +++ D+G+ + Q Y V +++ Sbjct: 111 YDVCEGMAFLESHQFIHRDLAARNCLVDRD-LCVKVSDFGMTRYVLDDQ-YVSSVGTKFP 168 Query: 197 --FKGPELLVDYQMYDYSLDMWSLGCML 222 + PE+ Y Y D+W+ G ++ Sbjct: 169 VKWSAPEVF-HYFKYSSKSDVWAFGILM 195 >5UIU-A nrPDB Length = 323 Score = 30.8 bits (68), Expect = 1.1, Method: Compositional matrix adjust. Identities = 34/149 (22%), Positives = 65/149 (43%), Gaps = 19/149 (12%) Query: 44 KLGRGKYSEVFEAINITNNEKVVVKILKPVK-------KKKIKREIKILENLRGGPNIIT 96 K+G G + V++ NN V VK L + K++ +EIK++ + N++ Sbjct: 54 KMGEGGFGVVYKGY--VNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQH-ENLVE 110 Query: 97 LADIVKDPVSRTPALVFEHVNNTDFKQLYQTL-----TDYDIRFYMYE-ILKALDYCHSM 150 L D LV+ ++ N L + +R + + +++ H Sbjct: 111 LLGFSSD--GDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHEN 168 Query: 151 GIMHRDVKPHNVMIDHEHRKLRLIDWGLA 179 +HRD+K N+++D E ++ D+GLA Sbjct: 169 HHIHRDIKSANILLD-EAFTAKISDFGLA 196 >3LMG-A nrPDB Length = 344 Score = 30.4 bits (67), Expect = 1.2, Method: Compositional matrix adjust. Identities = 24/97 (24%), Positives = 47/97 (48%), Gaps = 4/97 (4%) Query: 139 EILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHP-GQEYNVRVASRYF 197 +I K + Y G++HR++ NV++ ++++ D+G+A+ P ++ A Sbjct: 141 QIAKGMYYLEEHGMVHRNLAARNVLLKSP-SQVQVADFGVADLLPPDDKQLLYSEAKTPI 199 Query: 198 KGPEL-LVDYQMYDYSLDMWSLGCMLAS-MIFRKEPF 232 K L + + Y + D+WS G + M F EP+ Sbjct: 200 KWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEPY 236 >5LPZ-A nrPDB Length = 332 Score = 30.4 bits (67), Expect = 1.4, Method: Compositional matrix adjust. Identities = 24/85 (28%), Positives = 43/85 (50%), Gaps = 9/85 (10%) Query: 152 IMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEY---NVRVASRYFKGPELLVDYQM 208 I+HRD+K NV++D E+ + R+ D+G+A + + + + PE YQ Sbjct: 141 IIHRDMKSSNVLLD-ENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEY---YQS 196 Query: 209 YDYSL--DMWSLGCMLASMIFRKEP 231 + S D++S G +L ++ K P Sbjct: 197 FRCSTKGDVYSYGVVLLELLTGKRP 221 >3JB4-B nrPDB Length = 259 Score = 30.4 bits (67), Expect = 1.4, Method: Compositional matrix adjust. Identities = 21/102 (20%), Positives = 42/102 (41%), Gaps = 7/102 (6%) Query: 160 HNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLG 219 H ++HR+ + L + + P Q++ SRYF Q+ ++++ S G Sbjct: 93 HGTWTTNQHRQALVASITLLQAFWPNQDFPAWGQSRYFAAVRCGFHIQV-QLNVNIGSAG 151 Query: 220 CMLASMIFRKEP------FFHGHDNYDQLVRIAKVLGTEDLY 255 C++A+ + + F + N ++ A DLY Sbjct: 152 CLIAAYMPKTAHDHMNTYTFGSYTNLPHVLMNAATTSQADLY 193 >6J6I-B nrPDB Length = 351 Score = 30.0 bits (66), Expect = 1.6, Method: Compositional matrix adjust. Identities = 22/68 (32%), Positives = 33/68 (48%), Gaps = 11/68 (16%) Query: 109 PALVFEHVNNTDFKQL-------YQTLTDYDIRFYM-YEILKALDYCHSMG---IMHRDV 157 P LVFE + Q ++L + +R + EI A+ Y H+ I+HRDV Sbjct: 133 PVLVFEFAEHGAMNQRGGVIVNGEESLLPWSVRLKIGKEIANAVTYLHTAFPKIIIHRDV 192 Query: 158 KPHNVMID 165 KP +V +D Sbjct: 193 KPMHVFLD 200 >5VDK-A nrPDB Length = 297 Score = 30.0 bits (66), Expect = 1.6, Method: Compositional matrix adjust. Identities = 11/31 (35%), Positives = 20/31 (64%) Query: 137 MYEILKALDYCHSMGIMHRDVKPHNVMIDHE 167 + +I L+Y H+ ++H D+KP N+ I H+ Sbjct: 125 LLQISLGLNYIHNSSMVHLDIKPSNIFICHK 155 >5LPV-A nrPDB Length = 296 Score = 30.0 bits (66), Expect = 1.8, Method: Compositional matrix adjust. Identities = 24/85 (28%), Positives = 43/85 (50%), Gaps = 9/85 (10%) Query: 152 IMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEY---NVRVASRYFKGPELLVDYQM 208 I+HRD+K NV++D E+ + R+ D+G+A + + + + PE YQ Sbjct: 141 IIHRDMKSSNVLLD-ENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEY---YQS 196 Query: 209 YDYSL--DMWSLGCMLASMIFRKEP 231 + S D++S G +L ++ K P Sbjct: 197 FRCSTKGDVYSYGVVLLELLTGKRP 221 >1JKF-A nrPDB Length = 533 Score = 29.6 bits (65), Expect = 2.5, Method: Compositional matrix adjust. Identities = 14/48 (29%), Positives = 28/48 (58%) Query: 65 VVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALV 112 +V+K +KPV K+ + E + GG N I++ ++ +D + TP ++ Sbjct: 400 IVIKYMKPVGDSKVAMDEYYSELMLGGHNRISIHNVCEDSLLATPLII 447 >4V1O-Q nrPDB Length = 734 Score = 29.3 bits (64), Expect = 3.2, Method: Compositional matrix adjust. Identities = 16/48 (33%), Positives = 24/48 (50%), Gaps = 4/48 (8%) Query: 314 TAREAMEHPYFYTVVKDQARMGSSSM----PGGSTPVSSANMMSGISS 357 TAR+ + P + +KD A G +SM G S P +S N S + + Sbjct: 193 TARDGSQTPVIDSAIKDNATNGVNSMTATATGSSVPPASPNPASAVEN 240 >4OAU-C nrPDB Length = 699 Score = 28.9 bits (63), Expect = 4.0, Method: Compositional matrix adjust. Identities = 13/33 (39%), Positives = 20/33 (60%), Gaps = 1/33 (3%) Query: 134 RFYMYEILKALDYCH-SMGIMHRDVKPHNVMID 165 R + I KA+ H S G H+D++P N++ID Sbjct: 442 RNVLSSIFKAVQELHLSCGYTHQDLQPQNILID 474 >5UU1-A nrPDB Length = 324 Score = 28.5 bits (62), Expect = 5.0, Method: Compositional matrix adjust. Identities = 20/68 (29%), Positives = 36/68 (52%), Gaps = 8/68 (11%) Query: 118 NTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEH-RKLRLIDW 176 N FK+ T+ IR +L L+Y H +H D+K N+++ +++ ++ L D+ Sbjct: 124 NGTFKK--STVLQLGIR-----MLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADY 176 Query: 177 GLAEFYHP 184 GL+ Y P Sbjct: 177 GLSYRYCP 184 >3LY6-A nrPDB Length = 697 Score = 28.5 bits (62), Expect = 5.3, Method: Compositional matrix adjust. Identities = 16/49 (32%), Positives = 25/49 (51%), Gaps = 2/49 (4%) Query: 1 MSGPVPSRARVYTDVNTH--RPREYWDYESHVVEWGNQDDYQLVRKLGR 47 GPVP RA D++T P + + + VV+W QDD + + + R Sbjct: 370 CCGPVPVRAIKEGDLSTKYDAPFVFAEVNADVVDWIQQDDGSVHKSINR 418 >4W6Q-A nrPDB Length = 333 Score = 28.5 bits (62), Expect = 5.4, Method: Compositional matrix adjust. Identities = 17/50 (34%), Positives = 24/50 (48%), Gaps = 7/50 (14%) Query: 5 VPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVF 54 +P+ VYTD N P + VV+ Q D QL+ K+ G Y V+ Sbjct: 190 IPTELHVYTDHNMQLP-------TTVVKEPYQSDEQLIMKMSEGGYGLVW 232 >5OAT-A nrPDB Length = 411 Score = 28.5 bits (62), Expect = 5.6, Method: Compositional matrix adjust. Identities = 23/98 (23%), Positives = 43/98 (43%), Gaps = 15/98 (15%) Query: 151 GIMHRDVKPHNVMIDH---EHRKLRLIDWGLA------EFYHPGQEYNV-RVASRYFKGP 200 GI HRD+K N+++D E L + D+G P Y + + + P Sbjct: 173 GIAHRDLKSDNLLLDTSEPESPILVISDFGCCLADKTNGLSLPYTSYEMDKGGNTALMAP 232 Query: 201 ELLVD----YQMYDYS-LDMWSLGCMLASMIFRKEPFF 233 E++ + + +YS D+W++G + + PF+ Sbjct: 233 EIICQKPGTFSVLNYSKADLWAVGAIAYEIFNCHNPFY 270 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 4MD7-E nrPDB 566 e-162 6EII-A nrPDB 478 e-135 6HMD-A nrPDB 412 e-115 2PVN-A nrPDB 386 e-108 6O6Q-A nrPDB 386 e-107 5XVU-A nrPDB 365 e-101 4LFI-A nrPDB 329 1e-90 5JN2-A nrPDB 308 2e-84 3NCG-A nrPDB 306 7e-84 5Z33-A nrPDB 305 2e-83 2BPM-A nrPDB 303 9e-83 4EWQ-A nrPDB 300 6e-82 3OHT-A nrPDB 299 1e-81 5AIR-A nrPDB 299 2e-81 3NIZ-A nrPDB 299 2e-81 1CM8-A nrPDB 296 9e-81 3LIJ-A nrPDB 296 1e-80 3HZT-A nrPDB 296 1e-80 4MVF-A nrPDB 296 1e-80 6GU6-A nrPDB 295 3e-80 3MA6-A nrPDB 292 2e-79 4KRC-A nrPDB 291 3e-79 3DFA-A nrPDB 291 4e-79 4MYG-A nrPDB 290 6e-79 1V0B-A nrPDB 290 7e-79 3DXN-A nrPDB 290 7e-79 1G3N-A nrPDB 290 9e-79 4YZB-A nrPDB 289 2e-78 3OZ6-A nrPDB 286 2e-77 4QTB-A nrPDB 285 2e-77 5NGU-A nrPDB 284 3e-77 2F9G-A nrPDB 284 5e-77 4AGU-A nrPDB 284 6e-77 5EFQ-A nrPDB 284 6e-77 3Q5I-A nrPDB 283 1e-76 6DTL-A nrPDB 282 2e-76 3GC9-A nrPDB 281 4e-76 4AU8-A nrPDB 281 5e-76 4NST-A nrPDB 280 8e-76 4RGJ-A nrPDB 279 1e-75 4E7W-A nrPDB 279 1e-75 5FG8-A nrPDB 276 9e-75 3HDN-A nrPDB 276 1e-74 4IC8-A nrPDB 276 1e-74 5AWM-A nrPDB 275 2e-74 2VN9-A nrPDB 275 3e-74 4QNY-A nrPDB 274 3e-74 2BDW-A nrPDB 274 3e-74 3KK8-A nrPDB 273 1e-73 4ZSG-A nrPDB 271 2e-73 4BBM-A nrPDB 271 3e-73 3E7O-A nrPDB 271 3e-73 1UA2-A nrPDB 271 4e-73 5U6Y-A nrPDB 271 5e-73 2V7O-A nrPDB 270 7e-73 2J90-A nrPDB 270 9e-73 2YAB-A nrPDB 269 1e-72 5Y86-A nrPDB 269 2e-72 3MIA-A nrPDB 269 2e-72 1JNK-A nrPDB 269 2e-72 2VZ6-A nrPDB 269 2e-72 2XS0-A nrPDB 268 2e-72 3FI2-A nrPDB 268 3e-72 2A27-A nrPDB 268 4e-72 3BHH-A nrPDB 268 4e-72 3PG1-A nrPDB 268 4e-72 4NIF-A nrPDB 266 9e-72 3SOA-A nrPDB 266 1e-71 2JC6-A nrPDB 265 2e-71 5G6V-A nrPDB 265 2e-71 3GC0-A nrPDB 265 2e-71 5WAX-A nrPDB 264 6e-71 2X4F-A nrPDB 264 6e-71 1ZWS-A nrPDB 263 8e-71 4FG9-A nrPDB 263 1e-70 5IG1-A nrPDB 263 1e-70 2W4O-A nrPDB 263 1e-70 3E3P-A nrPDB 262 2e-70 5ES1-A nrPDB 261 3e-70 5XZW-A nrPDB 261 4e-70 3F3Z-A nrPDB 261 4e-70 2YCR-A nrPDB 261 5e-70 3GUB-A nrPDB 260 9e-70 3RP9-A nrPDB 259 1e-69 4BGQ-A nrPDB 259 1e-69 1PHK-A nrPDB 259 1e-69 4JG6-A nrPDB 259 2e-69 3ZDU-A nrPDB 259 2e-69 5YKS-A nrPDB 259 2e-69 3N9X-A nrPDB 259 2e-69 3MN3-A nrPDB 258 2e-69 3NIE-A nrPDB 258 3e-69 3I6U-A nrPDB 257 6e-69 3UC3-A nrPDB 257 6e-69 2JAM-A nrPDB 257 6e-69 3UTO-A nrPDB 256 9e-69 3TAC-A nrPDB 256 1e-68 2Y7J-A nrPDB 256 1e-68 2QNJ-A nrPDB 256 1e-68 5KCV-A nrPDB 256 1e-68 3H4J-B nrPDB 256 1e-68 3ZUT-A nrPDB 255 2e-68 1KOA-A nrPDB 254 3e-68 2JDO-A nrPDB 254 4e-68 5KZ7-A nrPDB 254 6e-68 2HW6-A nrPDB 254 7e-68 4PDS-A nrPDB 253 7e-68 2W96-B nrPDB 253 8e-68 4O2Z-A nrPDB 253 1e-67 4REW-A nrPDB 253 1e-67 3MV5-A nrPDB 252 2e-67 1KOB-A nrPDB 251 4e-67 1FOT-A nrPDB 251 6e-67 5JZN-A nrPDB 250 8e-67 2HAK-A nrPDB 250 9e-67 4CFH-A nrPDB 250 1e-66 4RED-A nrPDB 250 1e-66 4CFF-A nrPDB 249 1e-66 5EZV-A nrPDB 249 1e-66 5F9E-A nrPDB 249 2e-66 6C9D-A nrPDB 249 2e-66 3D2K-A nrPDB 249 2e-66 3IS5-A nrPDB 248 2e-66 3UDB-A nrPDB 248 3e-66 3KN6-A nrPDB 248 3e-66 3EB0-A nrPDB 247 4e-66 4UZD-A nrPDB 246 9e-66 2YZA-A nrPDB 246 9e-66 5D9K-A nrPDB 246 1e-65 5ZTN-A nrPDB 245 2e-65 4D28-A nrPDB 245 2e-65 3COM-A nrPDB 245 2e-65 4L42-A nrPDB 245 3e-65 4JXF-A nrPDB 244 4e-65 2I6L-A nrPDB 244 4e-65 1VZO-A nrPDB 244 4e-65 3TXO-A nrPDB 244 5e-65 4D2V-A nrPDB 244 5e-65 2UV2-A nrPDB 244 7e-65 4CQG-A nrPDB 243 7e-65 4RLP-A nrPDB 243 1e-64 6FD3-A nrPDB 243 1e-64 1NY3-A nrPDB 243 1e-64 4CZT-A nrPDB 242 2e-64 5D7A-A nrPDB 242 2e-64 2OZA-A nrPDB 242 2e-64 3KA0-A nrPDB 241 3e-64 6CKI-A nrPDB 241 4e-64 5N23-A nrPDB 241 4e-64 4RA4-A nrPDB 241 6e-64 3A8W-A nrPDB 240 1e-63 6CMJ-A nrPDB 239 1e-63 5X8I-B nrPDB 239 1e-63 4WB7-A nrPDB 239 1e-63 2Z7Q-A nrPDB 239 2e-63 5X3F-B nrPDB 239 2e-63 3FXW-A nrPDB 239 2e-63 6FDY-U nrPDB 238 3e-63 4LG4-A nrPDB 236 9e-63 3DAK-A nrPDB 236 1e-62 6HXF-B nrPDB 236 1e-62 4AW2-A nrPDB 235 2e-62 3TKU-A nrPDB 235 2e-62 6FYV-A nrPDB 235 3e-62 3ORZ-A nrPDB 235 3e-62 6AO5-A nrPDB 235 3e-62 3LM0-A nrPDB 233 1e-61 5YV8-A nrPDB 232 1e-61 5J5T-A nrPDB 232 2e-61 3NYO-A nrPDB 232 2e-61 4TNB-A nrPDB 232 2e-61 4I6B-A nrPDB 232 2e-61 4KS7-A nrPDB 232 3e-61 3Q53-A nrPDB 231 3e-61 4YNZ-A nrPDB 231 3e-61 6BDL-A nrPDB 231 4e-61 2F57-A nrPDB 230 6e-61 5LOH-A nrPDB 230 7e-61 3DB8-A nrPDB 230 8e-61 4B6L-A nrPDB 230 1e-60 3RAW-A nrPDB 230 1e-60 3PFQ-A nrPDB 229 1e-60 5DYK-A nrPDB 229 1e-60 6E9W-A nrPDB 229 2e-60 5DBX-A nrPDB 228 3e-60 6ED6-A nrPDB 228 3e-60 3HKO-A nrPDB 228 4e-60 5UNP-A nrPDB 227 4e-60 2X7G-A nrPDB 227 5e-60 2I0E-A nrPDB 227 8e-60 4JDH-A nrPDB 226 1e-59 4FIE-A nrPDB 226 1e-59 4XBR-A nrPDB 225 3e-59 1TKI-A nrPDB 224 4e-59 2Q0N-A nrPDB 224 4e-59 4C0T-A nrPDB 224 4e-59 4U41-A nrPDB 223 1e-58 4QMW-A nrPDB 222 2e-58 4CRL-A nrPDB 222 2e-58 2XIK-A nrPDB 222 2e-58 5FET-A nrPDB 222 2e-58 3VN9-A nrPDB 222 2e-58 4WNO-A nrPDB 221 4e-58 2OU7-A nrPDB 221 4e-58 4WUA-A nrPDB 221 4e-58 4J52-A nrPDB 221 4e-58 4B8L-A nrPDB 221 4e-58 2WO6-A nrPDB 221 4e-58 6E2O-A nrPDB 221 6e-58 3C51-A nrPDB 220 8e-58 6QAU-A nrPDB 220 1e-57 4AF3-A nrPDB 219 1e-57 4FZF-B nrPDB 218 3e-57 6CQF-A nrPDB 217 4e-57 4FR4-A nrPDB 217 5e-57 2VD5-A nrPDB 217 5e-57 4OTD-A nrPDB 217 6e-57 5UUU-A nrPDB 217 8e-57 3PVW-A nrPDB 216 2e-56 2BRG-A nrPDB 215 3e-56 3ALO-A nrPDB 213 9e-56 6CCF-A nrPDB 213 1e-55 4APC-A nrPDB 212 2e-55 2JD5-A nrPDB 212 2e-55 3FME-A nrPDB 211 3e-55 4CSV-A nrPDB 211 4e-55 6BXI-A nrPDB 211 4e-55 5TQX-A nrPDB 211 5e-55 1U5R-A nrPDB 211 5e-55 2GCD-A nrPDB 210 7e-55 3M42-A nrPDB 209 2e-54 4OLI-A nrPDB 209 2e-54 4F9B-A nrPDB 209 2e-54 4CRS-A nrPDB 209 2e-54 4KIK-B nrPDB 208 3e-54 4YHJ-A nrPDB 208 3e-54 6DBM-A nrPDB 206 1e-53 3EQC-A nrPDB 206 1e-53 3QA8-A nrPDB 206 1e-53 5KKR-C nrPDB 206 1e-53 2XNP-A nrPDB 206 1e-53 2WQN-A nrPDB 206 2e-53 4E20-A nrPDB 204 5e-53 4PWN-A nrPDB 203 1e-52 5O2C-A nrPDB 201 4e-52 5O2B-A nrPDB 201 4e-52 6GQK-A nrPDB 200 9e-52 5X02-A nrPDB 200 1e-51 1ZXE-A nrPDB 200 1e-51 5O0Y-A nrPDB 199 1e-51 4GS6-A nrPDB 199 2e-51 6DBN-A nrPDB 197 5e-51 5HI2-A nrPDB 197 8e-51 2DQ7-X nrPDB 197 1e-50 2OGV-A nrPDB 196 1e-50 3A4O-X nrPDB 196 1e-50 2H8H-A nrPDB 196 2e-50 3BEA-A nrPDB 196 2e-50 4AN9-A nrPDB 196 2e-50 6F3F-A nrPDB 195 2e-50 6GVJ-A nrPDB 195 2e-50 2WTK-C nrPDB 195 2e-50 3KRL-A nrPDB 195 3e-50 3DLS-A nrPDB 195 3e-50 4XUF-A nrPDB 195 3e-50 3G0E-A nrPDB 194 4e-50 3CJF-A nrPDB 194 5e-50 5H2U-A nrPDB 194 5e-50 2XYN-A nrPDB 194 6e-50 3HMP-A nrPDB 194 7e-50 1S9I-A nrPDB 194 7e-50 5SYS-A nrPDB 194 7e-50 3OMV-A nrPDB 194 7e-50 2VWV-A nrPDB 193 9e-50 3BGP-A nrPDB 193 1e-49 3IO7-A nrPDB 193 1e-49 2R2P-A nrPDB 193 1e-49 5AP3-A nrPDB 192 2e-49 4EQM-A nrPDB 192 2e-49 4RC3-A nrPDB 192 2e-49 4IAN-A nrPDB 192 2e-49 2ZMD-A nrPDB 192 3e-49 4XEY-B nrPDB 192 3e-49 5HIE-A nrPDB 192 3e-49 5TUR-A nrPDB 192 3e-49 2PL0-A nrPDB 192 3e-49 4R7H-A nrPDB 191 3e-49 4UY9-A nrPDB 191 6e-49 4EBW-A nrPDB 190 8e-49 2W1I-A nrPDB 190 8e-49 2FO0-A nrPDB 190 9e-49 3LLT-A nrPDB 190 9e-49 6NPU-A nrPDB 190 9e-49 4E93-A nrPDB 189 1e-48 3PPZ-A nrPDB 189 1e-48 3DTC-A nrPDB 189 2e-48 4H1J-A nrPDB 189 2e-48 2J0K-A nrPDB 189 2e-48 4X7Q-B nrPDB 189 3e-48 3TT0-A nrPDB 189 3e-48 3PP0-A nrPDB 188 4e-48 4AT3-A nrPDB 188 4e-48 4C59-A nrPDB 188 4e-48 3BBT-B nrPDB 187 5e-48 5A46-A nrPDB 187 7e-48 3GQL-A nrPDB 187 7e-48 3ORP-A nrPDB 187 7e-48 4UYA-A nrPDB 187 8e-48 2HK5-A nrPDB 187 8e-48 4P5Q-A nrPDB 187 9e-48 1FVR-A nrPDB 187 9e-48 3C1X-A nrPDB 186 1e-47 6HV0-A nrPDB 185 2e-47 5GRN-A nrPDB 185 2e-47 4JLC-A nrPDB 185 3e-47 5HLW-A nrPDB 185 3e-47 4PL5-B nrPDB 185 3e-47 2A1A-B nrPDB 184 5e-47 4HVI-A nrPDB 184 5e-47 1AD5-A nrPDB 184 6e-47 5X5O-A nrPDB 184 8e-47 2PMN-X nrPDB 184 9e-47 4EUT-A nrPDB 183 1e-46 2RIO-A nrPDB 182 2e-46 5B2L-A nrPDB 182 2e-46 4EUU-A nrPDB 182 3e-46 2PSQ-A nrPDB 182 3e-46 6O8B-A nrPDB 181 4e-46 6NT9-A nrPDB 181 4e-46 4K33-A nrPDB 180 1e-45 5EG3-A nrPDB 179 2e-45 3KUL-B nrPDB 179 2e-45 4XCU-A nrPDB 179 3e-45 4M7I-A nrPDB 178 5e-45 4XLV-A nrPDB 178 5e-45 4IDT-A nrPDB 177 5e-45 3UIU-A nrPDB 177 6e-45 6CTH-A nrPDB 177 7e-45 4Y83-A nrPDB 177 8e-45 2WTK-B nrPDB 176 2e-44 4LRM-A nrPDB 175 2e-44 5GNK-A nrPDB 175 4e-44 4G3E-A nrPDB 174 8e-44 6B2Q-A nrPDB 173 1e-43 4X3F-A nrPDB 173 1e-43 4OW8-A nrPDB 173 1e-43 3LZB-A nrPDB 173 1e-43 2BUJ-A nrPDB 172 3e-43 5TE0-A nrPDB 172 3e-43 5AMN-A nrPDB 172 3e-43 5HVK-A nrPDB 171 5e-43 5U6B-A nrPDB 169 1e-42 3PLS-A nrPDB 169 2e-42 5VD3-A nrPDB 167 5e-42 3QUP-A nrPDB 167 6e-42 4TPT-A nrPDB 167 1e-41 5FM2-A nrPDB 166 2e-41 5IKW-A nrPDB 165 3e-41 3ZZW-A nrPDB 164 8e-41 3MDY-A nrPDB 162 2e-40 6DC0-A nrPDB 159 1e-39 5CEK-A nrPDB 159 2e-39 4NEU-A nrPDB 157 6e-39 4M66-A nrPDB 156 2e-38 5L2Q-C nrPDB 155 2e-38 4LQP-A nrPDB 155 3e-38 3MY0-A nrPDB 155 4e-38 5WNL-A nrPDB 151 4e-37 2H34-A nrPDB 149 2e-36 3QD2-B nrPDB 147 5e-36 4TN6-A nrPDB 142 4e-34 3SV0-A nrPDB 140 7e-34 2CHL-A nrPDB 140 8e-34 5AR8-A nrPDB 140 1e-33 4BTK-A nrPDB 138 4e-33 5FQD-C nrPDB 137 6e-33 4NFN-A nrPDB 137 8e-33 2C47-A nrPDB 136 2e-32 2QLU-A nrPDB 135 2e-32 5X18-A nrPDB 135 3e-32 2CMW-A nrPDB 133 9e-32 4NT4-A nrPDB 133 1e-31 2PZI-A nrPDB 131 6e-31 4Y12-A nrPDB 130 7e-31 3HNG-A nrPDB 129 3e-30 4RT7-A nrPDB 128 4e-30 3VHK-A nrPDB 126 1e-29 1CSN-A nrPDB 123 8e-29 5M07-A nrPDB 122 3e-28 4XHH-A nrPDB 120 8e-28 4XHL-A nrPDB 117 7e-27 4IX6-A nrPDB 78 6e-15 Sequences not found previously or not previously below threshold: 3DKO-A nrPDB 191 5e-49 3V5Q-A nrPDB 190 6e-49 1JPA-A nrPDB 187 9e-48 5MJB-A nrPDB 185 2e-47 2Y6O-A nrPDB 185 3e-47 5L6P-A nrPDB 185 3e-47 4PDO-A nrPDB 183 1e-46 5KMM-A nrPDB 183 1e-46 3QGY-A nrPDB 182 3e-46 5VO2-A nrPDB 181 6e-46 6FEX-A nrPDB 180 7e-46 6BSD-A nrPDB 178 3e-45 6E4F-A nrPDB 177 5e-45 3SXS-A nrPDB 177 7e-45 4XI2-A nrPDB 176 1e-44 1LUF-A nrPDB 175 2e-44 1U59-A nrPDB 174 6e-44 4Y93-A nrPDB 173 9e-44 3ZBF-A nrPDB 173 1e-43 2OZO-A nrPDB 172 3e-43 1K9A-A nrPDB 170 9e-43 4YFF-A nrPDB 169 2e-42 1BYG-A nrPDB 167 5e-42 6FER-A nrPDB 167 6e-42 3I81-A nrPDB 165 2e-41 4HZS-A nrPDB 165 3e-41 5U6C-A nrPDB 164 5e-41 1U54-B nrPDB 164 9e-41 5UIU-A nrPDB 160 9e-40 3Q4U-A nrPDB 157 7e-39 5TOS-A nrPDB 155 3e-38 1PY5-A nrPDB 152 2e-37 3AOX-A nrPDB 152 2e-37 4F0G-A nrPDB 152 3e-37 3UIM-A nrPDB 151 4e-37 6J5U-C nrPDB 151 5e-37 3G2F-A nrPDB 150 7e-37 5LPZ-A nrPDB 150 1e-36 5C26-A nrPDB 150 1e-36 4FL3-A nrPDB 150 1e-36 5LPV-A nrPDB 149 2e-36 3LMG-A nrPDB 146 1e-35 5WNO-A nrPDB 145 2e-35 3SOC-A nrPDB 144 5e-35 5XD6-A nrPDB 140 1e-33 2Y4I-B nrPDB 139 2e-33 2QKW-B nrPDB 138 3e-33 5E8V-A nrPDB 138 3e-33 5VC6-A nrPDB 134 5e-32 5J0A-A nrPDB 134 7e-32 5VDK-A nrPDB 131 5e-31 6BFN-A nrPDB 120 2e-27 4MWI-A nrPDB 112 3e-25 5UV4-A nrPDB 112 4e-25 4BTF-A nrPDB 106 2e-23 4M69-B nrPDB 105 2e-23 4JRN-A nrPDB 104 7e-23 4L00-A nrPDB 103 1e-22 5USZ-A nrPDB 103 1e-22 5X1R-A nrPDB 103 2e-22 5OAT-A nrPDB 97 2e-20 6EQI-C nrPDB 96 3e-20 3REP-A nrPDB 92 3e-19 5CLR-A nrPDB 90 2e-18 6J6I-B nrPDB 89 4e-18 5DMZ-A nrPDB 85 4e-17 4L68-A nrPDB 84 1e-16 5C01-A nrPDB 84 1e-16 5UU1-A nrPDB 84 2e-16 4CI6-B nrPDB 83 2e-16 4WOV-A nrPDB 83 3e-16 6G4J-A nrPDB 82 5e-16 4I94-A nrPDB 80 1e-15 2RSV-A nrPDB 79 3e-15 2LAV-A nrPDB 78 6e-15 4O1O-A nrPDB 69 3e-12 2JII-A nrPDB 64 1e-10 4OAU-C nrPDB 63 2e-10 4CYJ-A nrPDB 58 9e-09 6EWX-A nrPDB 58 9e-09 5GZA-A nrPDB 57 2e-08 5GZ9-A nrPDB 56 2e-08 4AZW-A nrPDB 53 3e-07 6M7Z-A nrPDB 53 3e-07 6EAS-A nrPDB 52 4e-07 4AZV-A nrPDB 52 4e-07 6BHC-A nrPDB 49 3e-06 5VE6-A nrPDB 49 3e-06 3ENH-A nrPDB 49 3e-06 1TQM-A nrPDB 48 5e-06 6G38-A nrPDB 48 5e-06 4WWA-A nrPDB 45 4e-05 4CZY-B nrPDB 45 6e-05 2W1Z-A nrPDB 43 2e-04 3BYV-A nrPDB 43 3e-04 3DZO-A nrPDB 41 0.001 4BVU-A nrPDB 40 0.003 3Q60-A nrPDB 39 0.003 5YK0-A nrPDB 38 0.005 4BWP-A nrPDB 37 0.012 6G18-v nrPDB 36 0.028 5I35-A nrPDB 36 0.029 6FDN-A nrPDB 35 0.048 6EF6-A nrPDB 32 0.47 4BFR-A nrPDB 32 0.50 4P4S-A nrPDB 31 1.3 4P4S-B nrPDB 30 1.4 6DFL-A nrPDB 30 1.4 >4MD7-E nrPDB Length = 391 Score = 566 bits (1460), Expect = e-162, Method: Composition-based stats. Identities = 387/391 (98%), Positives = 387/391 (98%) Query: 1 MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINIT 60 MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINIT Sbjct: 1 MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINIT 60 Query: 61 NNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTD 120 NNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTD Sbjct: 61 NNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTD 120 Query: 121 FKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE 180 FKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE Sbjct: 121 FKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE 180 Query: 181 FYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYD 240 FYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYD Sbjct: 181 FYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYD 240 Query: 241 QLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDF 300 QLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDF Sbjct: 241 QLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDF 300 Query: 301 LDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPT 360 LDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGS PVSSANMMSGISSVP Sbjct: 301 LDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSEPVSSANMMSGISSVPE 360 Query: 361 PSPLGPLAGSPVIAAANPLGMPVPAAAGAQQ 391 P PLGPLAG PVIAAANPLGMPVPAAAGAQQ Sbjct: 361 PEPLGPLAGEPVIAAANPLGMPVPAAAGAQQ 391 >6EII-A nrPDB Length = 352 Score = 478 bits (1230), Expect = e-135, Method: Composition-based stats. Identities = 327/328 (99%), Positives = 327/328 (99%) Query: 2 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITN 61 SGPVPSRARVYTDVNTHRP EYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITN Sbjct: 25 SGPVPSRARVYTDVNTHRPSEYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITN 84 Query: 62 NEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDF 121 NEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDF Sbjct: 85 NEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDF 144 Query: 122 KQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF 181 KQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF Sbjct: 145 KQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF 204 Query: 182 YHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQ 241 YHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQ Sbjct: 205 YHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQ 264 Query: 242 LVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFL 301 LVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFL Sbjct: 265 LVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFL 324 Query: 302 DKLLRYDHQSRLTAREAMEHPYFYTVVK 329 DKLLRYDHQSRLTAREAMEHPYFYTVVK Sbjct: 325 DKLLRYDHQSRLTAREAMEHPYFYTVVK 352 >6HMD-A nrPDB Length = 365 Score = 412 bits (1058), Expect = e-115, Method: Composition-based stats. Identities = 289/356 (81%), Positives = 314/356 (88%), Gaps = 7/356 (1%) Query: 1 MSGPVP-SRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINI 59 M GP SRARVY +VN+ R REYWDYE+HV WGNQDDYQLVRKLGRGKYSEVFEAINI Sbjct: 16 MPGPAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINI 75 Query: 60 TNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNT 119 TNNE+VVVKILKPVKKKKIKRE+KILENLRGG NII L D VKDPVS+TPALVFE++NNT Sbjct: 76 TNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNT 135 Query: 120 DFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA 179 DFKQLYQ LTD+DIRFYMYE+LKALDYCHS GIMHRDVKPHNVMIDH+ +KLRLIDWGLA Sbjct: 136 DFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLA 195 Query: 180 EFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNY 239 EFYHP QEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFR+EPFFHG DNY Sbjct: 196 EFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNY 255 Query: 240 DQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALD 299 DQLVRIAKVLGTE+LY Y+ KY+I+LDP FNDILG+HSRKRWE F+HSEN+HLVSPEALD Sbjct: 256 DQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALD 315 Query: 300 FLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGI 355 LDKLLRYDHQ RLTA+EAMEHPYFY VVK+Q S P V S+ + + Sbjct: 316 LLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQ------SQPSADNAVLSSGLTAAR 365 >2PVN-A nrPDB Length = 352 Score = 386 bits (992), Expect = e-108, Method: Composition-based stats. Identities = 250/326 (76%), Positives = 286/326 (87%) Query: 3 GPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNN 62 G S+ARVY DVN RP+EYWDYE+ V+WG QDDY++VRK+GRGKYSEVFE IN+ NN Sbjct: 18 GSHMSKARVYADVNVLRPKEYWDYEALTVQWGEQDDYEVVRKVGRGKYSEVFEGINVNNN 77 Query: 63 EKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFK 122 EK ++KILKPVKKKKIKREIKIL+NL GGPNI+ L DIV+D S+TP+L+FE+VNNTDFK Sbjct: 78 EKCIIKILKPVKKKKIKREIKILQNLCGGPNIVKLLDIVRDQHSKTPSLIFEYVNNTDFK 137 Query: 123 QLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFY 182 LY TLTDYDIR+Y+YE+LKALDYCHS GIMHRDVKPHNVMIDHE RKLRLIDWGLAEFY Sbjct: 138 VLYPTLTDYDIRYYIYELLKALDYCHSQGIMHRDVKPHNVMIDHELRKLRLIDWGLAEFY 197 Query: 183 HPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQL 242 HPG+EYNVRVASRYFKGPELLVD Q YDYSLDMWSLGCM A MIFRKEPFF+GHDN+DQL Sbjct: 198 HPGKEYNVRVASRYFKGPELLVDLQDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQL 257 Query: 243 VRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLD 302 V+IAKVLGT+ L Y++KY IELDP+ ++GRHSRK W +F++++NQHLVSPEA+DFLD Sbjct: 258 VKIAKVLGTDGLNAYLNKYRIELDPQLEALVGRHSRKPWLKFMNADNQHLVSPEAIDFLD 317 Query: 303 KLLRYDHQSRLTAREAMEHPYFYTVV 328 KLLRYDHQ RLTA EAM HPYF V Sbjct: 318 KLLRYDHQERLTALEAMTHPYFQQVR 343 >6O6Q-A nrPDB Length = 335 Score = 386 bits (991), Expect = e-107, Method: Composition-based stats. Identities = 211/324 (65%), Positives = 265/324 (81%), Gaps = 1/324 (0%) Query: 5 VPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEK 64 V S +RVY DV + +P+ YWDY+ ++W Q++Y+++RKLGRGKYSEVF I++ EK Sbjct: 9 VQSVSRVYADVLSTKPQSYWDYDDLNIKWNPQENYEILRKLGRGKYSEVFLGIDLEKREK 68 Query: 65 VVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQL 124 VV+K+LKPVK+KKIKREI IL+NL GPNII + D+V++P S+TP L+FEH+NN DF+ L Sbjct: 69 VVIKVLKPVKRKKIKREISILKNLVDGPNIIAMLDVVREPQSKTPGLIFEHINNIDFRSL 128 Query: 125 YQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHP 184 Y T TDYDIRFYMYE+LKALDY HSMGIMHRDVKPHNVMIDH+ + LRLIDWGLAE+YHP Sbjct: 129 YPTFTDYDIRFYMYELLKALDYSHSMGIMHRDVKPHNVMIDHDKKLLRLIDWGLAEYYHP 188 Query: 185 GQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVR 244 G EYNVRVASRYFKGPELLVDY++YDYSLDMWS GCMLASM+F KEPFFHG N DQLV+ Sbjct: 189 GTEYNVRVASRYFKGPELLVDYRLYDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQLVQ 248 Query: 245 IAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKL 304 I +VLG+++ Y++KYNI L + DI G +++++W RF++ N+ LVS E LD +D+L Sbjct: 249 IVRVLGSKNFKKYLEKYNISLGEEYEDI-GYYNKRQWVRFMNENNKDLVSQEFLDLIDRL 307 Query: 305 LRYDHQSRLTAREAMEHPYFYTVV 328 LRYDHQ RLTA+EAM+H YF + Sbjct: 308 LRYDHQERLTAKEAMKHAYFDPIR 331 >5XVU-A nrPDB Length = 332 Score = 365 bits (937), Expect = e-101, Method: Composition-based stats. Identities = 209/323 (64%), Positives = 261/323 (80%) Query: 10 RVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKI 69 + Y DVN H+P+EY+DY++ ++W + Y++++K+GRGKYSEVF + N +K+ Sbjct: 4 KFYADVNIHKPKEYYDYDNLELQWNKPNRYEIMKKIGRGKYSEVFNGYDTECNRPCAIKV 63 Query: 70 LKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLT 129 LKPVKKKKIKREIKIL+NL GGPNII L DIVKDPV++TP+L+FE++NN DFK LY T Sbjct: 64 LKPVKKKKIKREIKILQNLNGGPNIIKLLDIVKDPVTKTPSLIFEYINNIDFKTLYPKFT 123 Query: 130 DYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYN 189 D DIR+Y+Y+ILKALDYCHS GIMHRDVKPHN+MIDHE+R++RLI WGLAEFYHPGQEYN Sbjct: 124 DKDIRYYIYQILKALDYCHSQGIMHRDVKPHNIMIDHENRQIRLISWGLAEFYHPGQEYN 183 Query: 190 VRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVL 249 VRVASRY+KGPELL+D Q+YDYSLD+WSLGCMLA MIF+KEPFF GHDNYDQLV+IAKVL Sbjct: 184 VRVASRYYKGPELLIDLQLYDYSLDIWSLGCMLAGMIFKKEPFFCGHDNYDQLVKIAKVL 243 Query: 250 GTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDH 309 GTEDL+ Y+ KYNI+L P + +ILG + RK W F+ N + E +D +DK+L YDH Sbjct: 244 GTEDLHAYLKKYNIKLKPHYLNILGEYERKPWSHFLTQSNIDIAKDEVIDLIDKMLIYDH 303 Query: 310 QSRLTAREAMEHPYFYTVVKDQA 332 R+ +EAMEHPYF V ++ A Sbjct: 304 AKRIAPKEAMEHPYFREVREESA 326 >4LFI-A nrPDB Length = 374 Score = 329 bits (844), Expect = 1e-90, Method: Composition-based stats. Identities = 201/374 (53%), Positives = 257/374 (68%), Gaps = 43/374 (11%) Query: 1 MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWG-NQDDYQLVRKLGRGKYSEVFEAINI 59 M V S ARVYT++N R EYWDYE+ V++W N DY++ K+GRGKYSEVF+ + + Sbjct: 3 MKCRVWSEARVYTNINKQRTEEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKL 62 Query: 60 TNNEKVVVKI---------------LKPVKKKKI---------------KREIKILENLR 89 + K+V+K+ L + +K+ ++E +L+ +R Sbjct: 63 DSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKE-DVLKFIR 121 Query: 90 ---------GGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEI 140 G NII L DI+KDP+S+TPALVFE+V+N DF+ LY LTD +IRFYM+E+ Sbjct: 122 PYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPKLTDLEIRFYMFEL 181 Query: 141 LKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGP 200 LKALDYCHSMGIMHRDVKPHNVMIDH+++KLRLIDWGLAEFYH EYNVRVASR+FKGP Sbjct: 182 LKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGP 241 Query: 201 ELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDK 260 ELLVDY+MYDYSLD+WS G MLASMIF++EPFFHG N DQLV+I KVLGT D Y+ K Sbjct: 242 ELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLK 301 Query: 261 YNIELDPRFNDILGRHSRKRWERFVHSENQHL-VSPEALDFLDKLLRYDHQSRLTAREAM 319 Y I L F D+ ++ RK W RF++ N+HL + E +D +D LLRYDHQ RLTA+EAM Sbjct: 302 YEITLPREFYDM-DQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAM 360 Query: 320 EHPYFYTVVKDQAR 333 HP+F + + + Sbjct: 361 GHPWFAPIREQIEK 374 >5JN2-A nrPDB Length = 525 Score = 308 bits (790), Expect = 2e-84, Method: Composition-based stats. Identities = 80/339 (23%), Positives = 148/339 (43%), Gaps = 53/339 (15%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP------VKKKKIKREIKILENLRG 90 D Y+ R LG+G + EV + ++ VK++ K+ + RE+++L+ L Sbjct: 67 DRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQL-D 125 Query: 91 GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYC 147 PNI+ L + +D LV E + + ++ D + ++L + Y Sbjct: 126 HPNIMKLYEFFEDKG--YFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYM 183 Query: 148 HSMGIMHRDVKPHNVMIDHEHR--KLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVD 205 H I+HRD+KP N++++ + + +R+ID+GL+ + ++ ++ + Y+ PE+L Sbjct: 184 HKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVL-- 241 Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIEL 265 + YD D+WS G +L ++ PF +G + YD L ++ K KY EL Sbjct: 242 HGTYDEKCDVWSTGVILYILLSGCPPF-NGANEYDILKKVEK-----------GKYTFEL 289 Query: 266 DPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFY 325 VS A D + K+L Y R++AR+A++H + Sbjct: 290 P----------------------QWKKVSESAKDLIRKMLTYVPSMRISARDALDHEWIQ 327 Query: 326 TVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPL 364 T K+Q S +P + + G + + L Sbjct: 328 TYTKEQI---SVDVPSLDNAILNIRQFQGTQKLAQAALL 363 >3NCG-A nrPDB Length = 486 Score = 306 bits (785), Expect = 7e-84, Method: Composition-based stats. Identities = 80/342 (23%), Positives = 147/342 (42%), Gaps = 57/342 (16%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL-----KPVKKKKIKREIKILENLRGG 91 + Y +V LG+G + EV + + ++ VK++ K I RE+++L+ L Sbjct: 22 ERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKL-DH 80 Query: 92 PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCH 148 PNI+ L +I++D S + +V E + + +++D + ++ + Y H Sbjct: 81 PNIMKLFEILED--SSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMH 138 Query: 149 SMGIMHRDVKPHNVMIDHEHRK--LRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDY 206 I+HRD+KP N++++ + + +++ID+GL+ + + R+ + Y+ PE+L Sbjct: 139 KHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVL--R 196 Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 266 YD D+WS G +L ++ PF+ G + YD L R+ KY +L Sbjct: 197 GTYDEKCDVWSAGVILYILLSGTPPFY-GKNEYDILKRVE-----------TGKYAFDLP 244 Query: 267 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYT 326 +S +A D + K+L + R+TA + +EHP+ Sbjct: 245 ----------------------QWRTISDDAKDLIRKMLTFHPSLRITATQCLEHPWIQK 282 Query: 327 VVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLGPLA 368 SS P S S + M+ I L A Sbjct: 283 Y--------SSETPTISDLPSLESAMTNIRQFQAEKKLAQAA 316 >5Z33-A nrPDB Length = 425 Score = 305 bits (782), Expect = 2e-83, Method: Composition-based stats. Identities = 102/382 (26%), Positives = 189/382 (49%), Gaps = 30/382 (7%) Query: 30 VVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL-----KPVKKKKIKREIKI 84 ++ + Y + ++LG+G Y V A+N +E V +K + K + K+ REIK+ Sbjct: 24 NQDFIVDERYTVTKELGQGAYGIVCAAVNNQTSEGVAIKKVTNVFSKKILAKRALREIKL 83 Query: 85 LENLRGGPNIITLADI-VKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEI 140 L++ RG NI L D+ + P + ++E + D + ++ LTD + ++Y+I Sbjct: 84 LQHFRGHRNITCLYDMDIPRPDNFNETYLYEELMECDLAAIIRSGQPLTDAHFQSFIYQI 143 Query: 141 LKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE-----YNVRVASR 195 L L Y HS ++HRD+KP N++++ + +L++ D+GLA + E VA+R Sbjct: 144 LCGLKYIHSANVLHRDLKPGNLLVNADC-ELKICDFGLARGFSVDPEENAGYMTEYVATR 202 Query: 196 YFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLY 255 +++ PE+++ +Q Y ++D+WS+GC+LA ++ PFF G D DQL +I +LGT + Sbjct: 203 WYRAPEIMLSFQSYTKAIDVWSVGCILAELL-GGRPFFKGRDYVDQLNQILHILGTPN-E 260 Query: 256 DYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTA 315 + + + + L ++K + + N P+ALD LD++L +D SR++ Sbjct: 261 ETLSRIGSPRAQEYVRNLPFMAKKPFPTLFPNAN-----PDALDLLDRMLAFDPSSRISV 315 Query: 316 REAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSV------PTPSPLGPLAG 369 +A+EHPY + + A + + + + + G Sbjct: 316 EQALEHPYLH--IWHDASDEPDCPTTFNFDFEVVEDVGEMRKMILDEVYRFRQLVRTAPG 373 Query: 370 SPVIAAANPLGMPVPAAAGAQQ 391 + A + +P+PA AG Q Sbjct: 374 AGGHGAPHAPQVPIPAGAGQGQ 395 >2BPM-A nrPDB Length = 309 Score = 303 bits (776), Expect = 9e-83, Method: Composition-based stats. Identities = 90/306 (29%), Positives = 160/306 (52%), Gaps = 25/306 (8%) Query: 35 NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK-----KKIKREIKILENLR 89 + +++Q V K+G G Y V++A N E V +K ++ + REI +L+ L Sbjct: 5 DMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKEL- 63 Query: 90 GGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT-----LTDYDIRFYMYEILKAL 144 PNI+ L D++ LVFE + + D K+ + I+ Y++++L+ L Sbjct: 64 NHPNIVKLLDVIH--TENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGL 120 Query: 145 DYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH-PGQEYNVRVASRYFKGPELL 203 +CHS ++HRD+KP N++I+ E ++L D+GLA + P + Y V + +++ PE+L Sbjct: 121 AFCHSHRVLHRDLKPQNLLINTEG-AIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEIL 179 Query: 204 VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNI 263 + + Y ++D+WSLGC+ A M+ R+ F G DQL RI + LGT D + ++ Sbjct: 180 LGCKYYSTAVDIWSLGCIFAEMVTRRA-LFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSM 238 Query: 264 ELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323 P + + +R+ + + V + + L ++L YD R++A+ A+ HP+ Sbjct: 239 ---PDYKPSFPKWARQDFSKVVPP-----LDEDGRSLLSQMLHYDPNKRISAKAALAHPF 290 Query: 324 FYTVVK 329 F V K Sbjct: 291 FQDVTK 296 >4EWQ-A nrPDB Length = 383 Score = 300 bits (769), Expect = 6e-82, Method: Composition-based stats. Identities = 90/327 (27%), Positives = 168/327 (51%), Gaps = 22/327 (6%) Query: 11 VYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL 70 ++ + RP ++ E + W + YQ + +G G Y V A + +V VK L Sbjct: 20 FQSNASQERPT-FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKL 78 Query: 71 KP-----VKKKKIKREIKILENLRGGPNIITLADIV---KDPVSRTPALVFEHVNNTDFK 122 + K+ RE+++L++++ N+I L D+ + + H+ D Sbjct: 79 SRPFQSIIHAKRTYRELRLLKHMKH-ENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLN 137 Query: 123 QL--YQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE 180 + Q LTD ++F +Y+IL+ L Y HS I+HRD+KP N+ ++ + +L+++D+GLA Sbjct: 138 NIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDC-ELKILDFGLAR 196 Query: 181 FYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYD 240 H E VA+R+++ PE+++++ Y+ ++D+WS+GC++A ++ + F G D+ D Sbjct: 197 --HTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRT-LFPGTDHID 253 Query: 241 QLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDF 300 QL I +++GT + + K + E + L + + + N P A+D Sbjct: 254 QLKLILRLVGTPGA-ELLKKISSESARNYIQSLTQMPKMNFANVFIGAN-----PLAVDL 307 Query: 301 LDKLLRYDHQSRLTAREAMEHPYFYTV 327 L+K+L D R+TA +A+ H YF Sbjct: 308 LEKMLVLDSDKRITAAQALAHAYFAQY 334 >3OHT-A nrPDB Length = 389 Score = 299 bits (767), Expect = 1e-81, Method: Composition-based stats. Identities = 95/332 (28%), Positives = 173/332 (52%), Gaps = 24/332 (7%) Query: 7 SRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVV 66 S A +T + RP ++ E + W + YQ + +G G Y V + ++ + K+ Sbjct: 22 SAAAPFTMSHKERPT-FYRQELNKTIWEVPERYQTLSPVGSGAYGSVCSSYDVKSGLKIA 80 Query: 67 VKILKP-----VKKKKIKREIKILENLRGGPNIITLADIVKDPVS----RTPALVFEHVN 117 VK L + K+ RE+++L++++ N+I L D+ S LV H+ Sbjct: 81 VKKLSRPFQSIIHAKRTYRELRLLKHMKH-ENVIGLLDVFTPATSLEEFNDVYLVT-HLM 138 Query: 118 NTDFKQL--YQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLID 175 D + Q LTD ++F +Y+IL+ L Y HS I+HRD+KP N+ ++ + +L+++D Sbjct: 139 GADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDC-ELKILD 197 Query: 176 WGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHG 235 +GLA H E VA+R+++ PE+++++ Y+ ++D+WS+GC++A ++ + F G Sbjct: 198 FGLAR--HTDDEMTGYVATRWYRAPEIMLNWMHYNMTVDIWSVGCIMAELLTGRT-LFPG 254 Query: 236 HDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSP 295 D+ +QL +I ++ GT + E + + L + ++ + N P Sbjct: 255 TDHINQLQQIMRLTGTPPASVISRMPSHEAR-NYINSLPQMPKRNFADVFIGAN-----P 308 Query: 296 EALDFLDKLLRYDHQSRLTAREAMEHPYFYTV 327 A+D L+K+L D R+TA EA+ HPYF Sbjct: 309 LAVDLLEKMLVLDTDKRITASEALAHPYFSQY 340 >5AIR-A nrPDB Length = 430 Score = 299 bits (765), Expect = 2e-81, Method: Composition-based stats. Identities = 111/367 (30%), Positives = 173/367 (47%), Gaps = 42/367 (11%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIK-REIKILENLRGGPNIITL 97 Y + +G G + V++A + E V +K K ++ K+ K RE++I+ L NI+ L Sbjct: 66 YTDTKVIGNGSFGVVYQAKLCDSGELVAIK--KVLQDKRFKNRELQIMRKLDHC-NIVRL 122 Query: 98 ADIVKDPVSR----TPALVFEHVNNTDFK------QLYQTLTDYDIRFYMYEILKALDYC 147 + LV ++V T ++ + QTL ++ YMY++ ++L Y Sbjct: 123 RYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYI 182 Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQ 207 HS GI HRD+KP N+++D + L+L D+G A+ G+ + SRY++ PEL+ Sbjct: 183 HSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGAT 242 Query: 208 MYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDP 267 Y S+D+WS GC+LA ++ + P F G DQLV I KVLGT E++P Sbjct: 243 DYTSSIDVWSAGCVLAELLLGQ-PIFPGDSGVDQLVEIIKVLGTPTREQI-----REMNP 296 Query: 268 RFNDI-LGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYT 326 + + + W + PEA+ +LL Y +RLT EA H +F Sbjct: 297 NYTEFKFPQIKAHPWTKVFRPRTP----PEAIALCSRLLEYTPTARLTPLEACAHSFF-- 350 Query: 327 VVKDQARMGSSSMPGG-STPVSSANMMSGISSVPTPSPLGPLAGSP---VIAAANPLGMP 382 D+ R + +P G TP +SS P PL + P + AAA+P Sbjct: 351 ---DELRDPNVKLPNGRDTPALFNFTTQELSSNP---PLATILIPPHARIQAAASP---- 400 Query: 383 VPAAAGA 389 PA A A Sbjct: 401 -PANATA 406 >3NIZ-A nrPDB Length = 311 Score = 299 bits (765), Expect = 2e-81, Method: Composition-based stats. Identities = 94/307 (30%), Positives = 161/307 (52%), Gaps = 24/307 (7%) Query: 34 GNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK-----IKREIKILENL 88 G + YQ + K+G G Y V++A + + V +K ++ + + REI +L+ L Sbjct: 18 GLMEKYQKLEKVGEGTYGVVYKAKD-SQGRIVALKRIRLDAEDEGIPSTAIREISLLKEL 76 Query: 89 RGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----LTDYDIRFYMYEILKAL 144 PNI++L D++ R LVFE + D K++ L D I+ Y+Y++L+ + Sbjct: 77 -HHPNIVSLIDVIHS--ERCLTLVFEFMEK-DLKKVLDENKTGLQDSQIKIYLYQLLRGV 132 Query: 145 DYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH-PGQEYNVRVASRYFKGPELL 203 +CH I+HRD+KP N++I+ + L+L D+GLA + P + Y V + +++ P++L Sbjct: 133 AHCHQHRILHRDLKPQNLLINSDG-ALKLADFGLARAFGIPVRSYTHEVVTLWYRAPDVL 191 Query: 204 VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNI 263 + + Y S+D+WS+GC+ A MI K P F G + DQL +I +LGT + ++ + Sbjct: 192 MGSKKYSTSVDIWSIGCIFAEMITGK-PLFPGVTDDDQLPKIFSILGTPNPREWPQVQEL 250 Query: 264 ELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323 L + +K W + Q E +D L +L +D R++AR+AM HPY Sbjct: 251 PLWKQ--RTFQVFEKKPWSSIIPGFCQ-----EGIDLLSNMLCFDPNKRISARDAMNHPY 303 Query: 324 FYTVVKD 330 F + Sbjct: 304 FKDLDPQ 310 >1CM8-A nrPDB Length = 367 Score = 296 bits (759), Expect = 9e-81, Method: Composition-based stats. Identities = 98/338 (28%), Positives = 177/338 (52%), Gaps = 35/338 (10%) Query: 1 MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINIT 60 MS P P+R+ Y E W + Y+ ++ +G G Y V A++ Sbjct: 1 MSSPPPARSGFYRQ------------EVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGR 48 Query: 61 NNEKVVVKIL-KPVKKK----KIKREIKILENLRGGPNIITLADIVKDPVSRTP----AL 111 KV +K L +P + + + RE+++L+++R N+I L D+ + L Sbjct: 49 TGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRH-ENVIGLLDVFTPDETLDDFTDFYL 107 Query: 112 VFEHVNNTDFKQL--YQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHR 169 V + TD +L ++ L + I+F +Y++LK L Y H+ GI+HRD+KP N+ ++ + Sbjct: 108 VMPFM-GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDC- 165 Query: 170 KLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRK 229 +L+++D+GLA E V +R+++ PE+++++ Y ++D+WS+GC++A MI K Sbjct: 166 ELKILDFGLAR--QADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGK 223 Query: 230 EPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSEN 289 F G D+ DQL I KV GT +++ + + + L +K + + + Sbjct: 224 T-LFKGSDHLDQLKEIMKVTGTPPA-EFVQRLQSDEAKNYMKGLPELEKKDFASILTNA- 280 Query: 290 QHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTV 327 SP A++ L+K+L D + R+TA EA+ HPYF ++ Sbjct: 281 ----SPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESL 314 >3LIJ-A nrPDB Length = 494 Score = 296 bits (758), Expect = 1e-80, Method: Composition-based stats. Identities = 81/342 (23%), Positives = 147/342 (42%), Gaps = 57/342 (16%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK-----KKKIKREIKILENLRGG 91 + YQ V+KLG G Y EV + + + +KI++ K+ E+ +L+ L Sbjct: 37 EMYQRVKKLGSGAYGEVLLCRDKVTHVERAIKIIRKTSVSTSSNSKLLEEVAVLK-LLDH 95 Query: 92 PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCH 148 PNI+ L D +D R LV E + + D + ++L + Y H Sbjct: 96 PNIMKLYDFFEDK--RNYYLVMECYKGGELFDEIIHRMKFNEVDAAVIIKQVLSGVTYLH 153 Query: 149 SMGIMHRDVKPHNVMIDHEHRK--LRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDY 206 I+HRD+KP N++++ + + ++++D+GL+ + ++ R+ + Y+ PE+L Sbjct: 154 KHNIVHRDLKPENLLLESKEKDALIKIVDFGLSAVFENQKKMKERLGTAYYIAPEVL--R 211 Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 266 + YD D+WS+G +L ++ PF G + + L ++ K T D ++ Sbjct: 212 KKYDEKCDVWSIGVILFILLAGYPPF-GGQTDQEILRKVEKGKYTFDSPEW--------- 261 Query: 267 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYT 326 VS A D + ++L++D Q R++A++A+EHP+ Sbjct: 262 ------------------------KNVSEGAKDLIKQMLQFDSQRRISAQQALEHPWIK- 296 Query: 327 VVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLGPLA 368 M S G P S AN + + L A Sbjct: 297 ------EMCSKKESGIELP-SLANAIENMRKFQNSQKLAQAA 331 >3HZT-A nrPDB Length = 467 Score = 296 bits (758), Expect = 1e-80, Method: Composition-based stats. Identities = 81/346 (23%), Positives = 139/346 (40%), Gaps = 58/346 (16%) Query: 34 GNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPV------KKKKIKREIKILEN 87 G D YQ V+KLG G Y EV + + +KI+K + E+ +L+ Sbjct: 1 GLSDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQ 60 Query: 88 LRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQ---LYQTLTDYDIRFYMYEILKAL 144 L PNI+ L + +D R LV E + L Q ++ D M ++L Sbjct: 61 L-DHPNIMKLYEFFEDK--RNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLSGT 117 Query: 145 DYCHSMGIMHRDVKPHNVMIDHEHRK--LRLIDWGLAEFYHPGQEYNVRVASRYFKGPEL 202 Y H I+HRD+KP N++++ + R ++++D+GL+ + G + R+ + Y+ PE+ Sbjct: 118 TYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAPEV 177 Query: 203 LVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYN 262 L + YD D+WS G +L ++ PF G + + L R+ K + D D+ Sbjct: 178 L--RKKYDEKCDVWSCGVILYILLCGYPPF-GGQTDQEILKRVEKGKFSFDPPDWTQ--- 231 Query: 263 IELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHP 322 VS EA + +L Y+ R++A EA+ HP Sbjct: 232 ------------------------------VSDEAKQLVKLMLTYEPSKRISAEEALNHP 261 Query: 323 YFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLGPLA 368 + + S + + + + L A Sbjct: 262 WI-------VKFCSQKHTDV-GKHALTGALGNMKKFQSSQKLAQAA 299 >4MVF-A nrPDB Length = 506 Score = 296 bits (757), Expect = 1e-80, Method: Composition-based stats. Identities = 76/311 (24%), Positives = 140/311 (45%), Gaps = 47/311 (15%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKR---EIKILENLRGGP 92 +D Y + KLG+G Y V++ I+ N+ +K K + K I R EI+I++ L P Sbjct: 56 EDKYIIDEKLGQGTYGCVYKGIDKVTNQLYAIKEEKKDRLKNINRFFQEIEIMKKL-DHP 114 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCHS 149 NI+ L + ++ L+ E + + + T+ + M +I A+ Y HS Sbjct: 115 NIVKLYETYEN--DNYIYLIMELCSGRELFDSIIENGSFTEKNAATIMKQIFSAIFYLHS 172 Query: 150 MGIMHRDVKPHNVMIDHEHRK--LRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQ 207 + I+HRD+KP N + E++ L++ID+GL++ G+ + + Y+ P++L Sbjct: 173 LNIVHRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFTTTKAGTPYYVAPQVLDG-- 230 Query: 208 MYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDP 267 YD D+WS G ++ +++ PF+ G + + L ++ Sbjct: 231 KYDKKCDIWSSGVIMYTLLCGYPPFY-GDTDNEVLKKV---------------------- 267 Query: 268 RFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTV 327 K+ E + + +S +A + + KLL Y+ R T EA+ HP+ + Sbjct: 268 -----------KKGEFCFYENDWGSISSDAKNLITKLLTYNPNERCTIEEALNHPWITQM 316 Query: 328 VKDQARMGSSS 338 K + SS Sbjct: 317 TKSHEHVELSS 327 >6GU6-A nrPDB Length = 302 Score = 295 bits (755), Expect = 3e-80, Method: Composition-based stats. Identities = 87/315 (27%), Positives = 165/315 (52%), Gaps = 26/315 (8%) Query: 32 EWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK-----IKREIKILE 86 G+ +DY + K+G G Y V++ + T + V +K ++ +++ REI +L+ Sbjct: 2 PLGSMEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLK 61 Query: 87 NLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYD------IRFYMYEI 140 LR PNI++L D++ L+FE ++ D K+ ++ ++ Y+Y+I Sbjct: 62 ELRH-PNIVSLQDVL--MQDSRLYLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQI 117 Query: 141 LKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH-PGQEYNVRVASRYFKG 199 L+ + +CHS ++HRD+KP N++ID + ++L D+GLA + P + Y V + +++ Sbjct: 118 LQGIVFCHSRRVLHRDLKPQNLLID-DKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRS 176 Query: 200 PELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYID 259 PE+L+ Y +D+WS+G + A + K+P FHG DQL RI + LGT + + + Sbjct: 177 PEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPE 235 Query: 260 KYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAM 319 +++ +++ +W+ + + + LD L K+L YD R++ + A+ Sbjct: 236 VESLQ--------DYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMAL 287 Query: 320 EHPYFYTVVKDQARM 334 HPYF + +M Sbjct: 288 NHPYFNDLDNQIKKM 302 >3MA6-A nrPDB Length = 298 Score = 292 bits (747), Expect = 2e-79, Method: Composition-based stats. Identities = 74/306 (24%), Positives = 139/306 (45%), Gaps = 50/306 (16%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP------VKKKKIKREIKILENLRG 90 D Y+ R LG+G + EV + ++ VK++ K+ + RE+++L+ L Sbjct: 32 DRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQL-D 90 Query: 91 GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYC 147 PNI+ L + +D LV E + + ++ D + ++L + Y Sbjct: 91 HPNIMKLYEFFEDKG--YFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYM 148 Query: 148 HSMGIMHRDVKPHNVMIDHEHR--KLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVD 205 H I+HRD+KP N++++ + + +R+ID+GL+ + ++ ++ + Y+ PE+L Sbjct: 149 HKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVL-- 206 Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIEL 265 + YD D+WS G +L ++ PF +G + YD L ++ K T +L + Sbjct: 207 HGTYDEKCDVWSTGVILYILLSGCPPF-NGANEYDILKKVEKGKYTFELPQW-------- 257 Query: 266 DPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFY 325 VS A D + K+L Y R++AR+A++H + Sbjct: 258 -------------------------KKVSESAKDLIRKMLTYVPSMRISARDALDHEWIQ 292 Query: 326 TVVKDQ 331 T K+Q Sbjct: 293 TYTKEQ 298 >4KRC-A nrPDB Length = 317 Score = 291 bits (745), Expect = 3e-79, Method: Composition-based stats. Identities = 86/318 (27%), Positives = 167/318 (52%), Gaps = 23/318 (7%) Query: 35 NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK----KIKREIKILENLRG 90 + ++ + KLG G Y+ V++ +N T V +K +K ++ REI +++ L+ Sbjct: 3 SSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKH 62 Query: 91 GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---------QTLTDYDIRFYMYEIL 141 NI+ L D++ LVFE ++N D K+ + L ++++ +++L Sbjct: 63 -ENIVRLYDVIH--TENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLL 118 Query: 142 KALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH-PGQEYNVRVASRYFKGP 200 + L +CH I+HRD+KP N++I+ +L+L D+GLA + P ++ V + +++ P Sbjct: 119 QGLAFCHENKILHRDLKPQNLLINKRG-QLKLGDFGLARAFGIPVNTFSSEVVTLWYRAP 177 Query: 201 ELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDK 260 ++L+ + Y S+D+WS GC+LA MI K P F G ++ +QL I ++GT + + Sbjct: 178 DVLMGSRTYSTSIDIWSCGCILAEMITGK-PLFPGTNDEEQLKLIFDIMGTPNESLWP-- 234 Query: 261 YNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAME 320 ++ P++N + + + + + + + +DFL LL+ + RL+A++A+ Sbjct: 235 -SVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALH 293 Query: 321 HPYFYTVVKDQARMGSSS 338 HP+F + GS S Sbjct: 294 HPWFAEYYHHASMGGSRS 311 >3DFA-A nrPDB Length = 286 Score = 291 bits (745), Expect = 4e-79, Method: Composition-based stats. Identities = 71/304 (23%), Positives = 137/304 (45%), Gaps = 49/304 (16%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL-----KPVKKKKIKREIKILENLRGG 91 + Y +V LG+G + EV + + ++ VK++ K I RE+++L+ L Sbjct: 22 ERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKL-DH 80 Query: 92 PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCH 148 PNI+ L +I++D S + +V E + + +++D + ++ + Y H Sbjct: 81 PNIMKLFEILED--SSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMH 138 Query: 149 SMGIMHRDVKPHNVMIDHEHRK--LRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDY 206 I+HRD+KP N++++ + + +++ID+GL+ + + R+ + Y+ PE+L Sbjct: 139 KHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVL--R 196 Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 266 YD D+WS G +L ++ PF+ G + YD L R+ KY +L Sbjct: 197 GTYDEKCDVWSAGVILYILLSGTPPFY-GKNEYDILKRVE-----------TGKYAFDLP 244 Query: 267 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYT 326 +S +A D + K+L + R+TA + +EHP+ Sbjct: 245 ----------------------QWRTISDDAKDLIRKMLTFHPSLRITATQCLEHPWIQK 282 Query: 327 VVKD 330 + Sbjct: 283 YSSE 286 >4MYG-A nrPDB Length = 372 Score = 290 bits (743), Expect = 6e-79, Method: Composition-based stats. Identities = 93/335 (27%), Positives = 170/335 (50%), Gaps = 22/335 (6%) Query: 15 VNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK--- 71 ++ R + ++ + + W Y +G G Y V AI+ + EKV +K L Sbjct: 21 MSLIRKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPF 80 Query: 72 --PVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRT----PALVFEHVNNTDFKQLY 125 + K+ RE+ +L++++ N+I L D+ S LV + TD +++ Sbjct: 81 QSEIFAKRAYRELLLLKHMQH-ENVIGLLDVFTPASSLRNFYDFYLVMPFM-QTDLQKIM 138 Query: 126 Q-TLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHP 184 ++ I++ +Y++LK L Y HS G++HRD+KP N+ ++ + +L+++D+GLA H Sbjct: 139 GMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDC-ELKILDFGLAR--HA 195 Query: 185 GQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVR 244 E V +R+++ PE+++ + Y+ ++D+WS+GC++A M+ K F G D DQL + Sbjct: 196 DAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKT-LFKGKDYLDQLTQ 254 Query: 245 IAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKL 304 I KV G +++ K N + + L + RK + + SP+A D L+K+ Sbjct: 255 ILKVTGVPGT-EFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRA-----SPQAADLLEKM 308 Query: 305 LRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSM 339 L D RLTA +A+ HP+F + + Sbjct: 309 LELDVDKRLTAAQALTHPFFEPFRDPEEETEAQQP 343 >1V0B-A nrPDB Length = 288 Score = 290 bits (742), Expect = 7e-79, Method: Composition-based stats. Identities = 89/301 (29%), Positives = 161/301 (53%), Gaps = 25/301 (8%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK-----IKREIKILENLRG 90 + Y + K+G G Y V++A N E +K ++ K+ + REI IL+ L+ Sbjct: 1 MEKYHGLEKIGEGTYGVVYKAQN-NYGETFALKKIRLEKEDEGIPSTTIREISILKELKH 59 Query: 91 GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----LTDYDIRFYMYEILKALDY 146 NI+ L D++ + LVFEH++ D K+L L + ++ ++L + Y Sbjct: 60 S-NIVKLYDVIH--TKKRLVLVFEHLDQ-DLKKLLDVCEGGLESVTAKSFLLQLLNGIAY 115 Query: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH-PGQEYNVRVASRYFKGPELLVD 205 CH ++HRD+KP N++I+ E +L++ D+GLA + P ++Y V + +++ P++L+ Sbjct: 116 CHDRRVLHRDLKPQNLLINREG-ELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVLMG 174 Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIEL 265 + Y ++D+WS+GC+ A M+ P F G DQL+RI ++LGT + ++ N+ Sbjct: 175 SKKYSTTIDIWSVGCIFAEMVNGA-PLFPGVSEADQLMRIFRILGTPNSKNWP---NVTE 230 Query: 266 DPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFY 325 P+++ + WE F+ + +D L K+L+ D R+TA++A+EH YF Sbjct: 231 LPKYDPNFTVYEPLPWESFLKG-----LDESGIDLLSKMLKLDPNQRITAKQALEHAYFK 285 Query: 326 T 326 Sbjct: 286 E 286 >3DXN-A nrPDB Length = 287 Score = 290 bits (742), Expect = 7e-79, Method: Composition-based stats. Identities = 78/302 (25%), Positives = 131/302 (43%), Gaps = 50/302 (16%) Query: 34 GNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPV------KKKKIKREIKILEN 87 G D YQ V+KLG G Y EV + + +KI+K + E+ +L+ Sbjct: 18 GLSDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQ 77 Query: 88 LRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQ---LYQTLTDYDIRFYMYEILKAL 144 L PNI+ L + +D R LV E + L Q ++ D M ++L Sbjct: 78 L-DHPNIMKLYEFFEDK--RNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLSGT 134 Query: 145 DYCHSMGIMHRDVKPHNVMIDHEHRK--LRLIDWGLAEFYHPGQEYNVRVASRYFKGPEL 202 Y H I+HRD+KP N++++ + R ++++D+GL+ + G + R+ + Y+ PE+ Sbjct: 135 TYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAPEV 194 Query: 203 LVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYN 262 L + YD D+WS G +L ++ PF G + + L R+ K + D D+ Sbjct: 195 L--RKKYDEKCDVWSCGVILYILLCGYPPF-GGQTDQEILKRVEKGKFSFDPPDWTQ--- 248 Query: 263 IELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHP 322 VS EA + +L Y+ R++A EA+ HP Sbjct: 249 ------------------------------VSDEAKQLVKLMLTYEPSKRISAEEALNHP 278 Query: 323 YF 324 + Sbjct: 279 WI 280 >1G3N-A nrPDB Length = 326 Score = 290 bits (742), Expect = 9e-79, Method: Composition-based stats. Identities = 87/324 (26%), Positives = 155/324 (47%), Gaps = 30/324 (9%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNN-EKVVVKILKPVKKKK-----IKREIKILENLR- 89 Y+ V ++G G Y +VF+A ++ N V +K ++ ++ RE+ +L +L Sbjct: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 Query: 90 -GGPNIITLADIV---KDPVSRTPALVFEHVNNTDFKQLYQTLTD-----YDIRFYMYEI 140 PN++ L D+ + LVFEHV+ D + + I+ M+++ Sbjct: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQL 129 Query: 141 LKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGP 200 L+ LD+ HS ++HRD+KP N+++ +++L D+GLA Y V + +++ P Sbjct: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSG-QIKLADFGLARIYSFQMALTSVVVTLWYRAP 188 Query: 201 ELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDK 260 E+L+ Y +D+WS+GC+ A M FR++P F G + DQL +I V+G D+ Sbjct: 189 EVLLQSS-YATPVDLWSVGCIFAEM-FRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRD 246 Query: 261 YNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAME 320 + S + E+FV + D L K L ++ R++A A+ Sbjct: 247 VALP-----RQAFHSKSAQPIEKFVTD-----IDELGKDLLLKCLTFNPAKRISAYSALS 296 Query: 321 HPYFYTVVKDQARMGSSSMPGGST 344 HPYF + + + + S P +T Sbjct: 297 HPYFQDLERCKENLDSHLPPSQNT 320 >4YZB-A nrPDB Length = 491 Score = 289 bits (739), Expect = 2e-78, Method: Composition-based stats. Identities = 75/338 (22%), Positives = 143/338 (42%), Gaps = 51/338 (15%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK-----IKREIKILENLRGG 91 D Y+ R LG+G + EV + ++ VK++ + K+ + + L Sbjct: 30 DRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTDKELLLKEVELLKKLDH 89 Query: 92 PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCH 148 PNI+ L + +D LV E + + ++ D + ++L + Y H Sbjct: 90 PNIMKLYEFFEDKG--YFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMH 147 Query: 149 SMGIMHRDVKPHNVMIDHEHR--KLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDY 206 I+HRD+KP N++++++ + +R+ID+GL+ + ++ ++ + Y+ PE+L + Sbjct: 148 KNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAPEVL--H 205 Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 266 YD D+WS G +L ++ PF +G + +D L ++ K T DL + Sbjct: 206 GTYDEKCDVWSTGVILYILLSGCPPF-NGANEFDILKKVEKGKFTFDLPQW--------- 255 Query: 267 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYT 326 VS A D + K+L Y R++AR+A+EH + T Sbjct: 256 ------------------------KKVSEPAKDLIRKMLAYVPTMRISARDALEHEWLKT 291 Query: 327 VVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPL 364 A S +P + + + G + + L Sbjct: 292 TD---AATDSIDVPSLESTILNIRQFQGTQKLAAAALL 326 >3OZ6-A nrPDB Length = 388 Score = 286 bits (731), Expect = 2e-77, Method: Composition-based stats. Identities = 93/325 (28%), Positives = 160/325 (49%), Gaps = 42/325 (12%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL-----KPVKKKKIKREIKILENLRGGP 92 Y+LV+KLG+G Y V+++I+ E V VK + ++ REI IL L G Sbjct: 10 KYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIFDAFQNSTDAQRTFREIMILTELSGHE 69 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT--LTDYDIRFYMYEILKALDYCHSM 150 NI+ L ++++ R LVF+++ TD + + L ++ +Y+++K + Y HS Sbjct: 70 NIVNLLNVLRADNDRDVYLVFDYME-TDLHAVIRANILEPVHKQYVVYQLIKVIKYLHSG 128 Query: 151 GIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFY----------------------HPGQEY 188 G++HRD+KP N++++ E +++ D+GL+ + Sbjct: 129 GLLHRDMKPSNILLNAECH-VKVADFGLSRSFVNIRRVTNNIPLSINENTENFDDDQPIL 187 Query: 189 NVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKV 248 VA+R+++ PE+L+ Y +DMWSLGC+L ++ K P F G +QL RI V Sbjct: 188 TDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGK-PIFPGSSTMNQLERIIGV 246 Query: 249 LGTEDLYDYID------KYNIELDPRFNDILGRHSRK---RWERFVHSENQH-LVSPEAL 298 + D K IE +I + R +W+ + N + EAL Sbjct: 247 IDFPSNEDVESIQSPFAKTMIESLKEKVEIRQSNKRDIFTKWKNLLLKINPKADCNEEAL 306 Query: 299 DFLDKLLRYDHQSRLTAREAMEHPY 323 D LDKLL+++ R++A +A++HP+ Sbjct: 307 DLLDKLLQFNPNKRISANDALKHPF 331 >4QTB-A nrPDB Length = 380 Score = 285 bits (729), Expect = 2e-77, Method: Composition-based stats. Identities = 90/340 (26%), Positives = 165/340 (48%), Gaps = 29/340 (8%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK----KIKREIKILENLRGGPN 93 Y ++ +G G Y V A + +V +K + P + + + REI+IL R N Sbjct: 42 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRH-EN 100 Query: 94 IITLADIVKDPV---SRTPALVFEHVNNTDFKQLYQT--LTDYDIRFYMYEILKALDYCH 148 +I + DI++ R +V + + TD +L ++ L++ I +++Y+IL+ L Y H Sbjct: 101 VIGIRDILRASTLEAMRDVYIVQDLME-TDLYKLLKSQQLSNDHICYFLYQILRGLKYIH 159 Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVR----VASRYFKGPELLV 204 S ++HRD+KP N++I+ L++ D+GLA P ++ VA+R+++ PE+++ Sbjct: 160 SANVLHRDLKPSNLLINTTC-DLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIML 218 Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIE 264 + + Y S+D+WS+GC+LA M+ + P F G DQL I +LG+ D N++ Sbjct: 219 NSKGYTKSIDIWSVGCILAEMLSNR-PIFPGKHYLDQLNHILGILGSPSQEDLNCIINMK 277 Query: 265 LDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 + L ++ W + + +ALD LD++L ++ R+T EA+ HPY Sbjct: 278 AR-NYLQSLPSKTKVAWAKLFPKSD-----SKALDLLDRMLTFNPNKRITVEEALAHPYL 331 Query: 325 YTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPL 364 + P P + A + + + Sbjct: 332 EQY------YDPTDEPVAEEPFTFAMELDDLPKERLKELI 365 >5NGU-A nrPDB Length = 381 Score = 284 bits (728), Expect = 3e-77, Method: Composition-based stats. Identities = 93/340 (27%), Positives = 164/340 (48%), Gaps = 29/340 (8%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK----KIKREIKILENLRGGPN 93 Y + +G G Y V A + N +V +K + P + + + REIKIL R N Sbjct: 43 RYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRH-EN 101 Query: 94 IITLADIVKDPV---SRTPALVFEHVNNTDFKQLYQT--LTDYDIRFYMYEILKALDYCH 148 II + DI++ P + +V + + TD +L +T L++ I +++Y+IL+ L Y H Sbjct: 102 IIGINDIIRAPTIEQMKDVYIVQDLME-TDLYKLLKTQHLSNDHICYFLYQILRGLKYIH 160 Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVR----VASRYFKGPELLV 204 S ++HRD+KP N++++ L++ D+GLA P ++ VA+R+++ PE+++ Sbjct: 161 SANVLHRDLKPSNLLLNTTC-DLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIML 219 Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIE 264 + + Y S+D+WS+GC+LA M+ + P F G DQL I +LG+ D N++ Sbjct: 220 NSKGYTKSIDIWSVGCILAEMLSNR-PIFPGKHYLDQLNHILGILGSPSQEDLNCIINLK 278 Query: 265 LDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 + L ++ W R + + +ALD LDK+L ++ R+ +A+ HPY Sbjct: 279 AR-NYLLSLPHKNKVPWNRLFPNAD-----SKALDLLDKMLTFNPHKRIEVEQALAHPYL 332 Query: 325 YTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPL 364 S P P + + + Sbjct: 333 EQY------YDPSDEPIAEAPFKFDMELDDLPKEKLKELI 366 >2F9G-A nrPDB Length = 353 Score = 284 bits (727), Expect = 5e-77, Method: Composition-based stats. Identities = 90/324 (27%), Positives = 156/324 (48%), Gaps = 28/324 (8%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK----KIKREIKILENLRGGPN 93 D+QL LG G Y V A + E V +K ++P K + REIKIL++ + N Sbjct: 12 DFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKH-EN 70 Query: 94 IITLADIVKDPVSRTP--ALVFEHVNNTDFKQLY--QTLTDYDIRFYMYEILKALDYCHS 149 IIT+ +I + + + + TD ++ Q L+D I++++Y+ L+A+ H Sbjct: 71 IITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHG 130 Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE-----------YNVRVASRYFK 198 ++HRD+KP N++I+ + L++ D+GLA VA+R+++ Sbjct: 131 SNVIHRDLKPSNLLINS-NCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYR 189 Query: 199 GPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYI 258 PE+++ Y ++D+WS GC+LA + R+ P F G D QL+ I ++GT + + Sbjct: 190 APEVMLTSAKYSRAMDVWSCGCILAELFLRR-PIFPGRDYRHQLLLIFGIIGTPHSDNDL 248 Query: 259 DKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREA 318 + L + E+ V+P+ +D L ++L +D R+TA+EA Sbjct: 249 RCIESPRAREYIKSLPMYPAAPLEKMFP-----RVNPKGIDLLQRMLVFDPAKRITAKEA 303 Query: 319 MEHPYFYTV-VKDQARMGSSSMPG 341 +EHPY T + G P Sbjct: 304 LEHPYLQTYHDPNDEPEGEPIPPS 327 >4AGU-A nrPDB Length = 311 Score = 284 bits (726), Expect = 6e-77, Method: Composition-based stats. Identities = 88/324 (27%), Positives = 154/324 (47%), Gaps = 34/324 (10%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL-----KPVKKKKIKREIKILENLRG 90 + Y+ + K+G G Y VF+ N + V +K PV KK REI++L+ L+ Sbjct: 2 MEKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKH 61 Query: 91 GPNIITLADIVKDPVSRTPALVFEHVNNT---DFKQLYQTLTDYDIRFYMYEILKALDYC 147 PN++ L ++ + R LVFE+ ++T + + + + ++ ++ ++ L+A+++C Sbjct: 62 -PNLVNLLEVFRRK--RRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFC 118 Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH-PGQEYNVRVASRYFKGPELLVDY 206 H +HRDVKP N++I +H ++L D+G A P Y+ VA+R+++ PELLV Sbjct: 119 HKHNCIHRDVKPENILIT-KHSVIKLCDFGFARLLTGPSDYYDDEVATRWYRSPELLVGD 177 Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 266 Y +D+W++GC+ A ++ P + G + DQL I K LG +L Sbjct: 178 TQYGPPVDVWAIGCVFAELLSG-VPLWPGKSDVDQLYLIRKTLG-------------DLI 223 Query: 267 PRFNDILGRHSRKRWERFVHSENQHL-------VSPEALDFLDKLLRYDHQSRLTAREAM 319 PR + + + E+ +S AL L L D RLT + + Sbjct: 224 PRHQQVFSTNQYFSGVKIPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTERLTCEQLL 283 Query: 320 EHPYFYTVVKDQARMGSSSMPGGS 343 HPYF + + + P + Sbjct: 284 HHPYFENIREIEDLAKEHDKPAEN 307 >5EFQ-A nrPDB Length = 347 Score = 284 bits (726), Expect = 6e-77, Method: Composition-based stats. Identities = 88/331 (26%), Positives = 164/331 (49%), Gaps = 34/331 (10%) Query: 31 VEWGNQ--DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK-----IKREIK 83 ++WG + D + ++ +G G Y +V++A + E V +K ++ +K+ REIK Sbjct: 3 IDWGKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIK 62 Query: 84 ILENLRGGPNIITLADIVKDPVS--------RTPALVFEHVNNTDFKQLYQT----LTDY 131 IL L +II + +IV D LVFE++++ D L ++ + Sbjct: 63 ILRQLTHQ-SIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDH-DLMGLLESGLVHFNEN 120 Query: 132 DIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFY--HPGQEYN 189 I+ +M ++++ LDYCH +HRD+K N+++++ +++L D+GLA Y + Y Sbjct: 121 HIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRG-QIKLADFGLARLYSSEESRPYT 179 Query: 190 VRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVL 249 +V + +++ PELL+ + Y ++D+WS GC+L + K+P F + QL I+++ Sbjct: 180 NKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFT-KKPIFQANQELAQLELISRIC 238 Query: 250 GTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDH 309 G+ + D + P FN + + +R R E + ALD D +L D Sbjct: 239 GSPCPAVWPDVIKL---PYFNTMKPKKQYRRKLR----EEFVFIPAAALDLFDYMLALDP 291 Query: 310 QSRLTAREAMEHPYFYTVVKDQARMGSSSMP 340 R TA +A++ + V ++M +P Sbjct: 292 SKRCTAEQALQCEFLRDVEP--SKMPPPDLP 320 >3Q5I-A nrPDB Length = 504 Score = 283 bits (724), Expect = 1e-76, Method: Composition-based stats. Identities = 74/354 (20%), Positives = 143/354 (40%), Gaps = 69/354 (19%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK----------------KKKIKR 80 + Y VRKLG G Y EV + + +K++K + ++I Sbjct: 36 ESYFKVRKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYSDDNKNIEKFHEEIYN 95 Query: 81 EIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYM 137 EI +L++L PNII L D+ +D + LV E + + + D M Sbjct: 96 EISLLKSL-DHPNIIKLFDVFEDK--KYFYLVTEFYEGGELFEQIINRHKFDECDAANIM 152 Query: 138 YEILKALDYCHSMGIMHRDVKPHNVMIDHEHR--KLRLIDWGLAEFYHPGQEYNVRVASR 195 +IL + Y H I+HRD+KP N+++++++ ++++D+GL+ F+ + R+ + Sbjct: 153 KQILSGICYLHKHNIVHRDIKPENILLENKNSLLNIKIVDFGLSSFFSKDYKLRDRLGTA 212 Query: 196 YFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLY 255 Y+ PE+L + Y+ D+WS G ++ ++ PF G ++ D + ++ K Sbjct: 213 YYIAPEVL--KKKYNEKCDVWSCGVIMYILLCGYPPF-GGQNDQDIIKKVEK-------- 261 Query: 256 DYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTA 315 + + + +S EA + + +L YD+ R TA Sbjct: 262 -------------------------GKYYFDFNDWKNISDEAKELIKLMLTYDYNKRCTA 296 Query: 316 REAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLGPLAG 369 EA+ + + + ++ G +S + L A Sbjct: 297 EEALNSRWIKKYANNINKSDQKTLCG---------ALSNMRKFEGSQKLAQAAI 341 >6DTL-A nrPDB Length = 364 Score = 282 bits (721), Expect = 2e-76, Method: Composition-based stats. Identities = 80/297 (26%), Positives = 153/297 (51%), Gaps = 22/297 (7%) Query: 42 VRKLGRGKYSEVFEAINITNNEKVVVKIL-----KPVKKKKIKREIKILENLRGGPNIIT 96 + +G+G Y V A+N NE V +K + + K+ REIK+L + NI+ Sbjct: 35 IMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRH-MDHENIVA 93 Query: 97 LADIVKDPVSR---TPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYCHSM 150 + DI+ P+ + +E ++ TD Q+ ++ L++ ++++Y+IL+ L Y HS Sbjct: 94 IRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSA 152 Query: 151 GIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYD 210 ++HRD+KP N++++ + L++ D+GLA V +R+++ PELL++ Y Sbjct: 153 NVLHRDLKPSNLLLNA-NCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYT 211 Query: 211 YSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFN 270 ++D+WS+GC+ ++ RK P F G D+ QL + +++GT + Sbjct: 212 AAIDVWSVGCIFMELMDRK-PLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKR---- 266 Query: 271 DILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTV 327 + R ++ V P A+D ++K+L +D + R+T +A+ HPY ++ Sbjct: 267 ---YIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSL 320 >3GC9-A nrPDB Length = 370 Score = 281 bits (719), Expect = 4e-76, Method: Composition-based stats. Identities = 96/355 (27%), Positives = 170/355 (47%), Gaps = 25/355 (7%) Query: 22 EYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP-----VKKK 76 ++ E + W Q +R +G G Y V A + +KV VK L + + Sbjct: 13 GFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHAR 72 Query: 77 KIKREIKILENLRGGPNIITLADIVKDPVS----RTPALVFEHVNNTDFKQLYQT--LTD 130 + RE+++L++L+ N+I L D+ S LV + D + ++ L+D Sbjct: 73 RTYRELRLLKHLKH-ENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKSQALSD 130 Query: 131 YDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNV 190 ++F +Y++L+ L Y HS GI+HRD+KP NV ++ E +LR++D+GLA +E Sbjct: 131 EHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVN-EDSELRILDFGLAR--QADEEMTG 187 Query: 191 RVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLG 250 VA+R+++ PE+++++ Y+ ++D+WS+GC++A ++ K F G D DQL RI +V+G Sbjct: 188 YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKA-LFPGSDYIDQLKRIMEVVG 246 Query: 251 TEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQ 310 T + + K + E + L +K N P A+D L ++L D Sbjct: 247 TPS-PEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGAN-----PLAIDLLGRMLVLDSD 300 Query: 311 SRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLG 365 R++A EA+ H YF + P + + + + L Sbjct: 301 QRVSAAEALAHAYFSQY--HDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLS 353 >4AU8-A nrPDB Length = 296 Score = 281 bits (718), Expect = 5e-76, Method: Composition-based stats. Identities = 86/300 (28%), Positives = 152/300 (50%), Gaps = 23/300 (7%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK-----IKREIKILENLRGG 91 Y+ + K+G G Y VF+A N +E V +K ++ + REI +L+ L+ Sbjct: 6 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH- 64 Query: 92 PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----LTDYDIRFYMYEILKALDYC 147 NI+ L D++ + LVFE + D K+ + + L ++ +++++LK L +C Sbjct: 65 KNIVRLHDVLHS--DKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFC 121 Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH-PGQEYNVRVASRYFKGPELLVDY 206 HS ++HRD+KP N++I+ + +L+L D+GLA + P + Y+ V + +++ P++L Sbjct: 122 HSRNVLHRDLKPQNLLINR-NGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGA 180 Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 266 ++Y S+DMWS GC+ A + P F G+D DQL RI ++LGT + + Sbjct: 181 KLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDY 240 Query: 267 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYT 326 + S ++ D L LL+ + R++A EA++HPYF Sbjct: 241 KPYPMYPATTS--------LVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 292 >4NST-A nrPDB Length = 351 Score = 280 bits (716), Expect = 8e-76, Method: Composition-based stats. Identities = 85/330 (25%), Positives = 166/330 (50%), Gaps = 34/330 (10%) Query: 32 EWGNQ--DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK-----IKREIKI 84 +WG + D + ++ +G G Y +V++A + E V +K ++ +K+ REIKI Sbjct: 6 DWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKI 65 Query: 85 LENLRGGPNIITLADIVKDPVS--------RTPALVFEHVNNTDFKQLYQT----LTDYD 132 L L +++ + +IV D LVFE++++ D L ++ ++ Sbjct: 66 LRQLIH-RSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDH-DLMGLLESGLVHFSEDH 123 Query: 133 IRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE--YNV 190 I+ +M ++++ L+YCH +HRD+K N+++++ +++L D+GLA Y+ + Y Sbjct: 124 IKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSG-QIKLADFGLARLYNSEESRPYTN 182 Query: 191 RVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLG 250 +V + +++ PELL+ + Y ++D+WS GC+L + K+P F + QL I+++ G Sbjct: 183 KVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFT-KKPIFQANLELAQLELISRLCG 241 Query: 251 TEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQ 310 + + D + P FN + + +R R E + ALD LD +L D Sbjct: 242 SPCPAVWPDVIKL---PYFNTMKPKKQYRRRLR----EEFSFIPSAALDLLDHMLTLDPS 294 Query: 311 SRLTAREAMEHPYFYTVVKDQARMGSSSMP 340 R TA + ++ + V + ++M +P Sbjct: 295 KRCTAEQTLQSDFLKDV--ELSKMAPPDLP 322 >4RGJ-A nrPDB Length = 520 Score = 279 bits (715), Expect = 1e-75, Method: Composition-based stats. Identities = 71/345 (20%), Positives = 148/345 (42%), Gaps = 59/345 (17%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL------KPVKKKKIKREIKILENLR 89 + Y+ ++ LG+G + EV + + + +K++ + K+ + RE+++L+ L Sbjct: 59 NEQYKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKESLLREVELLKMLD 118 Query: 90 GGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDY 146 NI+ L + +D + LV + + + + D + +IL + Y Sbjct: 119 HI-NIMKLYEFFED--NNYYYLVSDVYTGGELFDEIISRKRFYEIDAARIIKQILSGITY 175 Query: 147 CHSMGIMHRDVKPHNVMIDHEHRK---LRLIDWGLAEFYHPGQEYNVRVASRYFKGPELL 203 H ++HRD+KP N++++ ++++ +++ID+GL+ + ++ ++ + Y+ P++L Sbjct: 176 MHKNNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHFEYSKKMKDKIGTAYYIAPDVL 235 Query: 204 VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNI 263 + YD D+WS G +L ++ PF +G + YD L ++ T DL + Sbjct: 236 --HGTYDEKCDIWSCGVILYILLSGCPPF-NGSNEYDILKKVEAGKYTFDLPQF------ 286 Query: 264 ELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323 +S +A D + K+L Y R++AR+A+EH + Sbjct: 287 ---------------------------KKISDKAKDLIKKMLMYTSAVRISARDALEHEW 319 Query: 324 FYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLGPLA 368 M S P S ++ I + L A Sbjct: 320 IK-------MMTSKDNLNIDIP-SLELSIANIRQFQSTQKLAQAA 356 >4E7W-A nrPDB Length = 394 Score = 279 bits (715), Expect = 1e-75, Method: Composition-based stats. Identities = 104/333 (31%), Positives = 168/333 (50%), Gaps = 29/333 (8%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIK-REIKILENLRGGPNIITL 97 Y + +G G + VF+A + ++E V +K K ++ K+ K RE++I+ ++ PN++ L Sbjct: 42 YTNCKVIGNGSFGVVFQAKLVESDE-VAIK--KVLQDKRFKNRELQIMRIVKH-PNVVDL 97 Query: 98 ADIVKDPVSRT----PALVFEHVNNTDFK------QLYQTLTDYDIRFYMYEILKALDYC 147 + LV E+V T ++ +L QT+ I+ YMY++L++L Y Sbjct: 98 KAFFYSNGDKKDEVFLNLVLEYVPETVYRASRHYAKLKQTMPMLLIKLYMYQLLRSLAYI 157 Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQ 207 HS+GI HRD+KP N+++D L+LID+G A+ G+ + SRY++ PEL+ Sbjct: 158 HSIGICHRDIKPQNLLLDPPSGVLKLIDFGSAKILIAGEPNVSYICSRYYRAPELIFGAT 217 Query: 208 MYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDP 267 Y ++D+WS GC++A ++ + P F G DQLV I KVLGT ++ Sbjct: 218 NYTTNIDIWSTGCVMAELMQGQ-PLFPGESGIDQLVEIIKVLGTPSREQIKTMNPNYMEH 276 Query: 268 RFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTV 327 +F I K + + P+A+D + +LL Y +RLTA EA+ HP+F Sbjct: 277 KFPQIRPHPFSKVF--------RPRTPPDAIDLISRLLEYTPSARLTAIEALCHPFF--- 325 Query: 328 VKDQARMGSSSMPGGSTPVSSANMMSGISSVPT 360 D+ R G + MP G N SV Sbjct: 326 --DELRTGEARMPNGRELPPLFNWTKEELSVRP 356 >5FG8-A nrPDB Length = 285 Score = 276 bits (707), Expect = 9e-75, Method: Composition-based stats. Identities = 70/299 (23%), Positives = 135/299 (45%), Gaps = 49/299 (16%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK-----KKIKREIKILENLRGG 91 D+Y + +LG+G +S V + + + KI+ K +K++RE +I L Sbjct: 14 DNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKL-HH 72 Query: 92 PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCH 148 PNI+ L D +++ LVF+ V + + + ++ D + +IL+++++CH Sbjct: 73 PNIVRLHDSIQE--ENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCH 130 Query: 149 SMGIMHRDVKPHNVMIDH--EHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLVD 205 G++HRD+KP N+++ + ++L D+GLA E Q + + + PE+L Sbjct: 131 QNGVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVL-K 189 Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIEL 265 + Y S+D+W+ G +L ++ PF+ + LY I + Sbjct: 190 KEPYGKSVDIWACGVILYILLVGYPPFWDEDQH--------------RLYSQIKAGAYDY 235 Query: 266 DPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 S V+PEA + ++++L + R+TA EA++HP+ Sbjct: 236 P--------------------SPEWDTVTPEAKNLINQMLTVNPNKRITAAEALKHPWI 274 >3HDN-A nrPDB Length = 373 Score = 276 bits (706), Expect = 1e-74, Method: Composition-based stats. Identities = 80/360 (22%), Positives = 142/360 (39%), Gaps = 59/360 (16%) Query: 34 GNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVK------ILKPVKKKKIKREIKILEN 87 D+ ++ +G+G + +V A + VK ILK ++K I E +L Sbjct: 35 AKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLK 94 Query: 88 LRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKAL 144 P ++ L + + V +++N + Q + RFY EI AL Sbjct: 95 NVKHPFLVGLHFSFQ--TADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASAL 152 Query: 145 DYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF-YHPGQEYNVRVASRYFKGPELL 203 Y HS+ I++RD+KP N+++D + + L D+GL + + + + PE+L Sbjct: 153 GYLHSLNIVYRDLKPENILLDSQGHIV-LTDFGLCKENIEHNSTTSTFCGTPEYLAPEVL 211 Query: 204 VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNI 263 Q YD ++D W LG +L M++ PF+ + T ++YD I + Sbjct: 212 -HKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRN--------------TAEMYDNILNKPL 256 Query: 264 ELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAR----EAM 319 +L P ++ A L+ LL+ D RL A+ E Sbjct: 257 QLKPN------------------------ITNSARHLLEGLLQKDRTKRLGAKDDFMEIK 292 Query: 320 EHPYFYTVVKD---QARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLGPLAGSPVIAAA 376 H +F + D ++ P S P + + P P+ +G S ++ A+ Sbjct: 293 SHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNAIGKAPDSVLVTAS 352 >4IC8-A nrPDB Length = 442 Score = 276 bits (705), Expect = 1e-74, Method: Composition-based stats. Identities = 91/380 (23%), Positives = 170/380 (44%), Gaps = 33/380 (8%) Query: 2 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITN 61 GPV + + S V + D+Y+++ +G G Y V A Sbjct: 20 PGPVKAEPAHTAASVAAKNLALLKARSFDVTFDVGDEYEIIETIGNGAYGVVSSARRRLT 79 Query: 62 NEKVVVKILKP-----VKKKKIKREIKILENLRGGPNIITLADIVKDPV----SRTPALV 112 ++V +K + K+ RE+KIL++ + NII + DI++ V ++ +V Sbjct: 80 GQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHD-NIIAIKDILRPTVPYGEFKSVYVV 138 Query: 113 FEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHR 169 + + +D Q+ Q LT +R+++Y++L+ L Y HS ++HRD+KP N++++ E+ Sbjct: 139 LDLME-SDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVN-ENC 196 Query: 170 KLRLIDWGLAEFYHPGQE-----YNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLAS 224 +L++ D+G+A VA+R+++ PEL++ Y ++D+WS+GC+ Sbjct: 197 ELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGE 256 Query: 225 MIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERF 284 M+ R++ F G + QL I VLGT I E + L WE Sbjct: 257 MLARRQ-LFPGKNYVHQLQLIMMVLGTPS-PAVIQAVGAERVRAYIQSLPPRQPVPWETV 314 Query: 285 VHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGST 344 ++ +AL L ++LR++ +R++A A+ HP+ P + Sbjct: 315 YPGADR-----QALSLLGRMLRFEPSARISAAAALRHPFLAKYH------DPDDEPDCAP 363 Query: 345 PVSSANMMSGISSVPTPSPL 364 P A ++ + Sbjct: 364 PFDFAFDREALTRERIKEAI 383 >5AWM-A nrPDB Length = 394 Score = 275 bits (703), Expect = 2e-74, Method: Composition-based stats. Identities = 80/346 (23%), Positives = 155/346 (44%), Gaps = 28/346 (8%) Query: 17 THRPREYWDYESHVVEWGNQD-----DYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL- 70 +HR ++ + VE G+ + Y +R +G G V A + + V +K L Sbjct: 19 SHRTMTTAQHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLS 78 Query: 71 ----KPVKKKKIKREIKILENLRGGPNIITLADIVKD----PVSRTPALVFEHVNNTDFK 122 K+ RE K+++ L NII L + + LV E ++ + Sbjct: 79 RPFQNVTHAKRAYREFKLMK-LVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQ 137 Query: 123 QLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFY 182 + L + + +Y++L + + HS GI+HRD+KP N+++ + L+++D+GLA Sbjct: 138 VIQMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADC-TLKILDFGLARTA 196 Query: 183 HPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQL 242 V +RY++ PE+++ Y ++D+WS+GC++ MI F G D+ DQ Sbjct: 197 GTTFMMTPYVVTRYYRAPEVILGM-GYTENVDIWSVGCIMGEMIRGGV-LFPGTDHIDQW 254 Query: 243 VRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHS--------ENQHLVS 294 +I + LGT ++ + + + + R++ ++R +N + Sbjct: 255 NKIIEQLGTPS-PSFMQRLQPTVR-NYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKA 312 Query: 295 PEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMP 340 +A + L K+L D + R++ EA++H Y + + P Sbjct: 313 SDARNLLSKMLVIDPEQRISVDEALKHEYINVWYDAEEVDAPAPEP 358 >2VN9-A nrPDB Length = 301 Score = 275 bits (703), Expect = 3e-74, Method: Composition-based stats. Identities = 76/299 (25%), Positives = 135/299 (45%), Gaps = 49/299 (16%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK-----KKKIKREIKILENLRGG 91 D+YQL +LG+G +S V + I ++ KI+ K +K++RE +I L+ Sbjct: 4 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKH- 62 Query: 92 PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCH 148 PNI+ L D + + LVF+ V + + + ++ D + +IL+++++CH Sbjct: 63 PNIVRLHDSISEEGFH--YLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCH 120 Query: 149 SMGIMHRDVKPHNVMI--DHEHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLVD 205 GI+HRD+KP N+++ + ++L D+GLA E Q + + + PE+L Sbjct: 121 LNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRK 180 Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIEL 265 Y +DMW+ G +L ++ PF+ + LY I + Sbjct: 181 -DPYGKPVDMWACGVILYILLVGYPPFWDEDQH--------------RLYQQIKAGAYDF 225 Query: 266 DPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 S V+PEA D ++K+L + R+TA EA++HP+ Sbjct: 226 P--------------------SPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWI 264 >4QNY-A nrPDB Length = 354 Score = 274 bits (702), Expect = 3e-74, Method: Composition-based stats. Identities = 92/308 (29%), Positives = 162/308 (52%), Gaps = 24/308 (7%) Query: 37 DDYQLVRKLGRGKYSEVFEAIN-ITNNEKVVVKILKP------VKKKKIKREIKILENLR 89 D Y L R +G G Y V A + ++N V +K + + K+I REIK+L + Sbjct: 20 DRYLLERIIGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFEEVILAKRILREIKLLAHF- 78 Query: 90 GGPNIITLADIV--KDPVS-RTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKA 143 NII L +I+ +DP + +V + + TD KQ+ ++ LT+ I+F++Y+ L+A Sbjct: 79 NDDNIIGLRNILTPEDPENFDHFYIVMDIME-TDLKQVLRSGQELTEAHIQFFIYQALRA 137 Query: 144 LDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHP-GQEYNVRVASRYFKGPEL 202 L HS G++HRD+ P N++++ + L++ D+GLA+ + G+ V R+++ PEL Sbjct: 138 LHIIHSAGVIHRDITPANILVNT-NCDLKICDFGLAKEENDQGEYMTDYVTMRWYRAPEL 196 Query: 203 LVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYN 262 +++ + Y +D+W +GC+L ++ P F G D +QL +I V+GT D I+ Sbjct: 197 VMEDKDYSAQIDVWGIGCILGELL-GSRPLFQGKDRVNQLDKIVDVIGTPSEED-INSVG 254 Query: 263 IELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHP 322 ++ + W + + SPEALD L +L ++ + R+T +AM HP Sbjct: 255 SSAAQKYLKKKSHRPQADWRQRYPTA-----SPEALDLLRHMLVFNPKRRITVLQAMRHP 309 Query: 323 YFYTVVKD 330 + + D Sbjct: 310 FLEQLHDD 317 >2BDW-A nrPDB Length = 362 Score = 274 bits (702), Expect = 3e-74, Method: Composition-based stats. Identities = 70/298 (23%), Positives = 136/298 (45%), Gaps = 48/298 (16%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK-----KKIKREIKILENLRGG 91 D+Y + +LG+G +S V ++ T + KI+ K +K++RE +I L+ Sbjct: 29 DNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQH- 87 Query: 92 PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCH 148 PNI+ L D +++ LVF+ V + + + ++ D + +IL+++ YCH Sbjct: 88 PNIVRLHDSIQEESFH--YLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCH 145 Query: 149 SMGIMHRDVKPHNVMIDH--EHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDY 206 S GI+HR++KP N+++ + ++L D+GLA + + ++ + + PE+L Sbjct: 146 SNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVL-KK 204 Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 266 Y +D+W+ G +L ++ PF+ + DQ A++ Y Sbjct: 205 DPYSKPVDIWACGVILYILLVGYPPFW----DEDQHRLYAQIKAGAYDY----------- 249 Query: 267 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 S V+PEA +D +L + + R+TA +A++ P+ Sbjct: 250 -------------------PSPEWDTVTPEAKSLIDSMLTVNPKKRITADQALKVPWI 288 >3KK8-A nrPDB Length = 284 Score = 273 bits (697), Expect = 1e-73, Method: Composition-based stats. Identities = 70/298 (23%), Positives = 136/298 (45%), Gaps = 48/298 (16%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK-----KKIKREIKILENLRGG 91 D+Y + +LG+G +S V ++ T + KI+ K +K++RE +I L+ Sbjct: 6 DNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQH- 64 Query: 92 PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCH 148 PNI+ L D +++ LVF+ V + + + ++ D + +IL+++ YCH Sbjct: 65 PNIVRLHDSIQEESFH--YLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCH 122 Query: 149 SMGIMHRDVKPHNVMIDH--EHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDY 206 S GI+HR++KP N+++ + ++L D+GLA + + ++ + + PE+L Sbjct: 123 SNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVL-KK 181 Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 266 Y +D+W+ G +L ++ PF+ + DQ A++ Y Sbjct: 182 DPYSKPVDIWACGVILYILLVGYPPFW----DEDQHRLYAQIKAGAYDY----------- 226 Query: 267 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 S V+PEA +D +L + + R+TA +A++ P+ Sbjct: 227 -------------------PSPEWDTVTPEAKSLIDSMLTVNPKKRITADQALKVPWI 265 >4ZSG-A nrPDB Length = 347 Score = 271 bits (694), Expect = 2e-73, Method: Composition-based stats. Identities = 87/351 (24%), Positives = 164/351 (46%), Gaps = 33/351 (9%) Query: 31 VEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP-----VKKKKIKREIKIL 85 V + D+Y+++ +G G Y V A ++V +K + K+ RE+KIL Sbjct: 1 VTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKIL 60 Query: 86 ENLRGGPNIITLADIVKDPV----SRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMY 138 ++ + NII + DI++ V ++ +V + + +D Q+ Q LT +R+++Y Sbjct: 61 KHFKHD-NIIAIKDILRPTVPYGEFKSVYVVLDLME-SDLHQIIHSSQPLTLEHVRYFLY 118 Query: 139 EILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE-----YNVRVA 193 ++L+ L Y HS ++HRD+KP N++++ E+ +L++ D+G+A VA Sbjct: 119 QLLRGLKYMHSAQVIHRDLKPSNLLVN-ENCELKIGDFGMARGLCTSPAEHQYFMTEYVA 177 Query: 194 SRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTED 253 +R+++ PEL++ Y ++D+WS+GC+ M+ R++ F G + QL I VLGT Sbjct: 178 TRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQ-LFPGKNYVHQLQLIMMVLGTPS 236 Query: 254 LYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRL 313 I E + L WE ++ +AL L ++LR++ +R+ Sbjct: 237 -PAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADR-----QALSLLGRMLRFEPSARI 290 Query: 314 TAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPL 364 +A A+ HP+ P + P A ++ + Sbjct: 291 SAAAALRHPFLAKYH------DPDDEPDCAPPFDFAFDREALTRERIKEAI 335 >4BBM-A nrPDB Length = 331 Score = 271 bits (694), Expect = 3e-73, Method: Composition-based stats. Identities = 86/312 (27%), Positives = 147/312 (47%), Gaps = 24/312 (7%) Query: 25 DYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL-----KPVKKKKIK 79 D + + + + + Y+ + +G G Y V + N V +K + KK Sbjct: 13 DLGTENLYFQSMEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAM 72 Query: 80 REIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNT---DFKQLYQTLTDYDIRFY 136 REIK+L+ LR N++ L ++ K + LVFE V++T D + L ++ Y Sbjct: 73 REIKLLKQLRH-ENLVNLLEVCKKK--KRWYLVFEFVDHTILDDLELFPNGLDYQVVQKY 129 Query: 137 MYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFY-HPGQEYNVRVASR 195 +++I+ + +CHS I+HRD+KP N+++ + ++L D+G A PG+ Y+ VA+R Sbjct: 130 LFQIINGIGFCHSHNIIHRDIKPENILV-SQSGVVKLCDFGFARTLAAPGEVYDDEVATR 188 Query: 196 YFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGT--ED 253 +++ PELLV Y ++D+W++GC++ M EP F G + DQL I LG Sbjct: 189 WYRAPELLVGDVKYGKAVDVWAIGCLVTEMFMG-EPLFPGDSDIDQLYHIMMCLGNLIPR 247 Query: 254 LYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRL 313 + +K + R +I R +R +S +D K L D R Sbjct: 248 HQELFNKNPVFAGVRLPEIKEREPLER--------RYPKLSEVVIDLAKKCLHIDPDKRP 299 Query: 314 TAREAMEHPYFY 325 E + H +F Sbjct: 300 FCAELLHHDFFQ 311 >3E7O-A nrPDB Length = 360 Score = 271 bits (693), Expect = 3e-73, Method: Composition-based stats. Identities = 76/301 (25%), Positives = 138/301 (45%), Gaps = 18/301 (5%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP-----VKKKKIKREIKILENLRGGP 92 YQ ++ +G G V A + V VK L K+ RE+ +L+ Sbjct: 23 RYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLK-CVNHK 81 Query: 93 NIITLADIVKD----PVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCH 148 NII+L ++ + LV E ++ + ++ L + + +Y++L + + H Sbjct: 82 NIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLH 141 Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQM 208 S GI+HRD+KP N+++ + L+++D+GLA V +RY++ PE+++ Sbjct: 142 SAGIIHRDLKPSNIVVKSDC-TLKILDFGLARTASTNFMMTPYVVTRYYRAPEVILGM-G 199 Query: 209 YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLY-----DYIDKYNI 263 Y ++D+WS+GC++ ++ F G D+ DQ ++ + LGT + + Sbjct: 200 YKENVDIWSVGCIMGELVKGSV-IFQGTDHIDQWNKVIEQLGTPSAEFMAALQPTVRNYV 258 Query: 264 ELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323 E P + I W SE + + +A D L K+L D R++ EA+ HPY Sbjct: 259 ENRPAYPGIAFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPY 318 Query: 324 F 324 Sbjct: 319 I 319 >1UA2-A nrPDB Length = 346 Score = 271 bits (692), Expect = 4e-73, Method: Composition-based stats. Identities = 96/340 (28%), Positives = 163/340 (47%), Gaps = 36/340 (10%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIK--------REIKILENLR 89 Y+ + LG G+++ V++A + N+ V +K +K + + K REIK+L+ L Sbjct: 11 RYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS 70 Query: 90 GGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ----TLTDYDIRFYMYEILKALD 145 PNII L D +LVF+ + TD + + + LT I+ YM L+ L+ Sbjct: 71 H-PNIIGLLDAFGHKS--NISLVFDFME-TDLEVIIKDNSLVLTPSHIKAYMLMTLQGLE 126 Query: 146 YCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFY-HPGQEYNVRVASRYFKGPELLV 204 Y H I+HRD+KP+N+++D E+ L+L D+GLA+ + P + Y +V +R+++ PELL Sbjct: 127 YLHQHWILHRDLKPNNLLLD-ENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLF 185 Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIE 264 +MY +DMW++GC+LA ++ R PF G + DQL RI + LGT + D ++ Sbjct: 186 GARMYGVGVDMWAVGCILAELLLR-VPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLP 244 Query: 265 LDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 F K + + LD + L ++ +R+TA +A++ YF Sbjct: 245 DYVTF---------KSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYF 295 Query: 325 YTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPL 364 PG P + + + + Sbjct: 296 S--------NRPGPTPGCQLPRPNCPVETLKEQSNPALAI 327 >5U6Y-A nrPDB Length = 461 Score = 271 bits (692), Expect = 5e-73, Method: Composition-based stats. Identities = 73/298 (24%), Positives = 133/298 (44%), Gaps = 49/298 (16%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK-----KKKIKREIKILENLRGGPN 93 YQL +LG+G +S V + + ++ KI+ K +K++RE +I L+ PN Sbjct: 2 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKH-PN 60 Query: 94 IITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCHSM 150 I+ L D + + L+F+ V + + + ++ D + +IL+A+ +CH M Sbjct: 61 IVRLHDSISEEGHH--YLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQM 118 Query: 151 GIMHRDVKPHNVMIDH--EHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLVDYQ 207 G++HRD+KP N+++ + ++L D+GLA E Q + + + PE+L Sbjct: 119 GVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRK-D 177 Query: 208 MYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDP 267 Y +D+W+ G +L ++ PF+ + LY I + Sbjct: 178 PYGKPVDLWACGVILYILLVGYPPFWDEDQH--------------RLYQQIKAGAYDFP- 222 Query: 268 RFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFY 325 S V+PEA D ++K+L + R+TA EA++HP+ Sbjct: 223 -------------------SPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWIS 261 >2V7O-A nrPDB Length = 336 Score = 270 bits (691), Expect = 7e-73, Method: Composition-based stats. Identities = 73/314 (23%), Positives = 139/314 (44%), Gaps = 49/314 (15%) Query: 21 REYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK-----K 75 E ++S DDYQL +LG+G +S V + T ++ KI+ K Sbjct: 15 TENLYFQSMATCTRFTDDYQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSARDH 74 Query: 76 KKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYD 132 +K++RE +I L+ PNI+ L D + + LVF+ V + + + ++ D Sbjct: 75 QKLEREARICRLLKH-PNIVRLHDSISEEGFH--YLVFDLVTGGELFEDIVAREYYSEAD 131 Query: 133 IRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHR--KLRLIDWGLA-EFYHPGQEYN 189 +++IL+++++ H I+HRD+KP N+++ + + ++L D+GLA E Q + Sbjct: 132 ASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWF 191 Query: 190 VRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVL 249 + + PE+L Y +D+W+ G +L ++ PF+ + Sbjct: 192 GFAGTPGYLSPEVLRK-DPYGKPVDIWACGVILYILLVGYPPFWDEDQH----------- 239 Query: 250 GTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDH 309 LY I + S V+PEA + ++++L + Sbjct: 240 ---KLYQQIKAGAYDFP--------------------SPEWDTVTPEAKNLINQMLTINP 276 Query: 310 QSRLTAREAMEHPY 323 R+TA +A++HP+ Sbjct: 277 AKRITADQALKHPW 290 >2J90-A nrPDB Length = 304 Score = 270 bits (690), Expect = 9e-73, Method: Composition-based stats. Identities = 77/313 (24%), Positives = 140/313 (44%), Gaps = 53/313 (16%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP---------VKKKKIKREIKILE 86 +D Y++ +LG G+++ V + ++ K +K V +++I+RE+ IL Sbjct: 25 EDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILR 84 Query: 87 NLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKA 143 +R PNIITL DI ++ L+ E V+ + ++LT+ + ++ +IL Sbjct: 85 EIRH-PNIITLHDIFENKTD--VVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDG 141 Query: 144 LDYCHSMGIMHRDVKPHNVMI---DHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGP 200 + Y HS I H D+KP N+M+ + + +++LID+G+A G E+ + F P Sbjct: 142 VHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFVAP 201 Query: 201 ELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDK 260 E +V+Y+ DMWS+G + ++ PF G + L I+ V Sbjct: 202 E-IVNYEPLGLEADMWSIGVITYILLSGASPFL-GETKQETLTNISAV------------ 247 Query: 261 YNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAME 320 N + D + S A DF+ +LL D + R+T +++E Sbjct: 248 -NYDFDEEY--------------------FSNTSELAKDFIRRLLVKDPKRRMTIAQSLE 286 Query: 321 HPYFYTVVKDQAR 333 H + + + R Sbjct: 287 HSWIKAIRRRNVR 299 >2YAB-A nrPDB Length = 361 Score = 269 bits (688), Expect = 1e-72, Method: Composition-based stats. Identities = 79/324 (24%), Positives = 141/324 (43%), Gaps = 53/324 (16%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK---------KKKIKREIKILE 86 +D Y + +LG G+++ V + + + K +K + +++I+RE+ IL Sbjct: 11 EDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIEREVSILR 70 Query: 87 NLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKA 143 + PNIITL D+ ++ L+ E V+ + ++L++ + ++ +IL Sbjct: 71 QVLH-PNIITLHDVYENRTD--VVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDG 127 Query: 144 LDYCHSMGIMHRDVKPHNVMIDHEHR---KLRLIDWGLAEFYHPGQEYNVRVASRYFKGP 200 ++Y H+ I H D+KP N+M+ ++ ++LID+GLA G E+ + F P Sbjct: 128 VNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAP 187 Query: 201 ELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDK 260 E +V+Y+ DMWS+G + ++ PF G + L I V Sbjct: 188 E-IVNYEPLGLEADMWSIGVITYILLSGASPFL-GDTKQETLANITAV------------ 233 Query: 261 YNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAME 320 + + D F S A DF+ KLL + + RLT +EA+ Sbjct: 234 -SYDFDEEF--------------------FSQTSELAKDFIRKLLVKETRKRLTIQEALR 272 Query: 321 HPYFYTVVKDQARMGSSSMPGGST 344 HP+ V QA + S+ Sbjct: 273 HPWITPVDTQQAMVRRESVVNLEN 296 >5Y86-A nrPDB Length = 588 Score = 269 bits (688), Expect = 2e-72, Method: Composition-based stats. Identities = 94/404 (23%), Positives = 179/404 (44%), Gaps = 77/404 (19%) Query: 17 THRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK- 75 H PR++ Y Y++++ +G+G + +V + + V +K+++ K+ Sbjct: 198 IHVPRDHLAY-----------RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRF 246 Query: 76 -KKIKREIKILENLR-----GGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT-- 127 ++ EI+ILE+L+ G N+I + + + FE ++ D +L + Sbjct: 247 HRQAAEEIRILEHLKKQDKTGSMNVIHMLESFT--FRNHVCMAFELLS-IDLYELIKKNK 303 Query: 128 ---LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHR-KLRLIDWGLAEFYH 183 + +R + IL++LD H I+H D+KP N+++ H R ++ID+G + F + Sbjct: 304 FQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEY 363 Query: 184 PGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLV 243 Q+ + SR+++ PE+++ + Y +D+WS GC+LA ++ + P F G D DQL Sbjct: 364 --QKLYTYIQSRFYRAPEIILGSR-YSTPIDIWSFGCILAELLTGQ-PLFPGEDEGDQLA 419 Query: 244 RIAKVLGTEDLYDYIDK------YNIELDPRFNDILGR--------------------HS 277 + ++LG N + PR+ + + Sbjct: 420 CMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPG 479 Query: 278 RKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSS 337 K W + + +L ++FL + L +D +RLT +A+ HP+ S Sbjct: 480 SKDWGTALKGCDDYL----FIEFLKRCLHWDPSARLTPAQALRHPWI-----------SK 524 Query: 338 SMPGGSTPVSSANMMSGISSVPTPSPLGPLAG--SPVIAAANPL 379 S+P P+++ + +SG V S L PV+ AN L Sbjct: 525 SVP---RPLTTIDKVSGKRVVNPASAFQGLGSKLPPVVGIANKL 565 >3MIA-A nrPDB Length = 351 Score = 269 bits (688), Expect = 2e-72, Method: Composition-based stats. Identities = 93/357 (26%), Positives = 164/357 (45%), Gaps = 38/357 (10%) Query: 25 DYESHVVEWGNQ-DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK-----I 78 Y+S + ++ Y+ + K+G+G + EVF+A + +KV +K + +K+ Sbjct: 4 QYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITA 63 Query: 79 KREIKILENLRGGPNIITLADIVKDPVSRT------PALVFEHVNN---TDFKQLYQTLT 129 REIKIL+ L+ N++ L +I + S LVF+ + + T Sbjct: 64 LREIKILQLLKH-ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFT 122 Query: 130 DYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ--- 186 +I+ M +L L Y H I+HRD+K NV+I + L+L D+GLA + + Sbjct: 123 LSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDG-VLKLADFGLARAFSLAKNSQ 181 Query: 187 --EYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVR 244 Y RV + +++ PELL+ + Y +D+W GC++A M R P G+ QL Sbjct: 182 PNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTR-SPIMQGNTEQHQLAL 240 Query: 245 IAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKL 304 I+++ G+ + + N EL + + G+ + + ++ P ALD +DKL Sbjct: 241 ISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVK-----DRLKAYVRDPYALDLIDKL 295 Query: 305 LRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTP 361 L D R+ + +A+ H +F+ S MP + S ++ S + P Sbjct: 296 LVLDPAQRIDSDDALNHDFFW----------SDPMPSDLKGMLSTHLTSMFEYLAPP 342 >1JNK-A nrPDB Length = 423 Score = 269 bits (687), Expect = 2e-72, Method: Composition-based stats. Identities = 79/331 (23%), Positives = 151/331 (45%), Gaps = 20/331 (6%) Query: 9 ARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVK 68 A+ Y + +++ E + YQ ++ +G G V A + + V +K Sbjct: 34 AKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIK 93 Query: 69 ILKP-----VKKKKIKREIKILENLRGGPNIITLADIVKD----PVSRTPALVFEHVNNT 119 L K+ RE+ +L NII+L ++ + LV E ++ Sbjct: 94 KLSRPFQNQTHAKRAYREL-VLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN 152 Query: 120 DFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA 179 + + L + + +Y++L + + HS GI+HRD+KP N+++ + L+++D+GLA Sbjct: 153 LCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDC-TLKILDFGLA 211 Query: 180 EFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNY 239 V +RY++ PE+++ Y ++D+WS+GC++ M+ R + F G D Sbjct: 212 RTAGTSFMMTPYVVTRYYRAPEVILGM-GYKENVDIWSVGCIMGEMV-RHKILFPGRDYI 269 Query: 240 DQLVRIAKVLGTEDLYDYIDKYNI------ELDPRFNDILGRHSRKRWERFVHSENQHLV 293 DQ ++ + LGT +++ K E P++ + SE+ L Sbjct: 270 DQWNKVIEQLGTP-CPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLK 328 Query: 294 SPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 + +A D L K+L D R++ +A++HPY Sbjct: 329 ASQARDLLSKMLVIDPAKRISVDDALQHPYI 359 >2VZ6-A nrPDB Length = 313 Score = 269 bits (687), Expect = 2e-72, Method: Composition-based stats. Identities = 74/301 (24%), Positives = 134/301 (44%), Gaps = 49/301 (16%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK-----KKKIKREIKILENLRG 90 Q YQL +LG+G +S V + + ++ KI+ K +K++RE +I L+ Sbjct: 21 QSMYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKH 80 Query: 91 GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYC 147 PNI+ L D + + L+F+ V + + + ++ D + +IL+A+ +C Sbjct: 81 -PNIVRLHDSISEEGHH--YLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHC 137 Query: 148 HSMGIMHRDVKPHNVMIDH--EHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLV 204 H MG++HRD+KP N+++ + ++L D+GLA E Q + + + PE+L Sbjct: 138 HQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLR 197 Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIE 264 Y +D+W+ G +L ++ PF+ + LY I + Sbjct: 198 K-DPYGKPVDLWACGVILYILLVGYPPFWDEDQH--------------RLYQQIKAGAYD 242 Query: 265 LDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 S V+PEA D ++K+L + R+TA EA++HP+ Sbjct: 243 FP--------------------SPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWI 282 Query: 325 Y 325 Sbjct: 283 S 283 >2XS0-A nrPDB Length = 386 Score = 268 bits (686), Expect = 2e-72, Method: Composition-based stats. Identities = 79/319 (24%), Positives = 143/319 (44%), Gaps = 21/319 (6%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP-----VKKKKIKREIKILENLRGGP 92 YQ ++ +G G V A + V +K L K+ RE+ +L Sbjct: 27 RYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYREL-VLMKCVNHK 85 Query: 93 NIITLADIVKDPVS----RTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCH 148 NII L ++ S + +V E ++ + + L + + +Y++L + + H Sbjct: 86 NIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLH 145 Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQM 208 S GI+HRD+KP N+++ + L+++D+GLA V +RY++ PE+++ Sbjct: 146 SAGIIHRDLKPSNIVVKSDC-TLKILDFGLARTAGTSFMMVPFVVTRYYRAPEVILGM-G 203 Query: 209 YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNI----- 263 Y ++D+WS+GC++ MI F G D+ DQ ++ + LGT +++ K Sbjct: 204 YKENVDIWSVGCIMGEMIKGGV-LFPGTDHIDQWNKVIEQLGTP-CPEFMKKLQPTVRTY 261 Query: 264 -ELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHP 322 E P++ SE+ L + +A D L K+L D R++ EA++HP Sbjct: 262 VENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHP 321 Query: 323 YFYT-VVKDQARMGSSSMP 340 Y +A +P Sbjct: 322 YINVWYDPSEAEAPPPKIP 340 >3FI2-A nrPDB Length = 353 Score = 268 bits (685), Expect = 3e-72, Method: Composition-based stats. Identities = 76/302 (25%), Positives = 142/302 (47%), Gaps = 20/302 (6%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP-----VKKKKIKREIKILENLRGGP 92 YQ ++ +G G V A + + V +K L K+ RE+ +L Sbjct: 25 RYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYREL-VLMKCVNHK 83 Query: 93 NIITLADIVKD----PVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCH 148 NII+L ++ + LV E ++ + + L + + +Y++L + + H Sbjct: 84 NIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLH 143 Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQM 208 S GI+HRD+KP N+++ + L+++D+GLA V +RY++ PE+++ Sbjct: 144 SAGIIHRDLKPSNIVVKSDC-TLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGM-G 201 Query: 209 YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNI----- 263 Y ++D+WS+GC++ M+ R + F G D DQ ++ + LGT +++ K Sbjct: 202 YKENVDIWSVGCIMGEMV-RHKILFPGRDYIDQWNKVIEQLGTP-CPEFMKKLQPTVRNY 259 Query: 264 -ELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHP 322 E P++ + SE+ L + +A D L K+L D R++ +A++HP Sbjct: 260 VENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHP 319 Query: 323 YF 324 Y Sbjct: 320 YI 321 >2A27-A nrPDB Length = 321 Score = 268 bits (684), Expect = 4e-72, Method: Composition-based stats. Identities = 78/324 (24%), Positives = 140/324 (43%), Gaps = 53/324 (16%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP---------VKKKKIKREIKILE 86 +D Y + +LG G+++ V + + + K +K V +++I+RE+ IL Sbjct: 11 EDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILR 70 Query: 87 NLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKA 143 + N+ITL D+ ++ L+ E V+ + ++L++ + ++ +IL Sbjct: 71 QVLHH-NVITLHDVYENRTD--VVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDG 127 Query: 144 LDYCHSMGIMHRDVKPHNVMIDHEHR---KLRLIDWGLAEFYHPGQEYNVRVASRYFKGP 200 ++Y H+ I H D+KP N+M+ ++ ++LID+GLA G E+ + F P Sbjct: 128 VNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAP 187 Query: 201 ELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDK 260 E +V+Y+ DMWS+G + ++ PF G + L I V Sbjct: 188 E-IVNYEPLGLEADMWSIGVITYILLSGASPFL-GDTKQETLANITAV------------ 233 Query: 261 YNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAME 320 + + D F S A DF+ KLL + + RLT +EA+ Sbjct: 234 -SYDFDEEF--------------------FSQTSELAKDFIRKLLVKETRKRLTIQEALR 272 Query: 321 HPYFYTVVKDQARMGSSSMPGGST 344 HP+ V QA + S+ Sbjct: 273 HPWITPVDNQQAMVRRESVVNLEN 296 >3BHH-A nrPDB Length = 295 Score = 268 bits (684), Expect = 4e-72, Method: Composition-based stats. Identities = 71/298 (23%), Positives = 134/298 (44%), Gaps = 49/298 (16%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK-----KKKIKREIKILENLRGG 91 D+YQL +G+G +S V + + + KI+ K +K++RE +I L+ Sbjct: 4 DEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHS 63 Query: 92 PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCH 148 NI+ L D + + LVF+ V + + + ++ D + +IL+A+ +CH Sbjct: 64 -NIVRLHDSISEEGFH--YLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCH 120 Query: 149 SMGIMHRDVKPHNVMIDHEHR--KLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLVD 205 MG++HRD+KP N+++ + + ++L D+GLA E Q + + + PE+L Sbjct: 121 QMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRK 180 Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIEL 265 + Y +D+W+ G +L ++ PF+ + LY I + Sbjct: 181 -EAYGKPVDIWACGVILYILLVGYPPFWDEDQH--------------KLYQQIKAGAYDF 225 Query: 266 DPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323 S V+PEA + ++++L + R+TA EA++HP+ Sbjct: 226 P--------------------SPEWDTVTPEAKNLINQMLTINPAKRITAHEALKHPW 263 >3PG1-A nrPDB Length = 362 Score = 268 bits (684), Expect = 4e-72, Method: Composition-based stats. Identities = 83/313 (26%), Positives = 147/313 (46%), Gaps = 31/313 (9%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL--------------KPVKKKKIKRE 81 Q Y + R + G Y V ++ V +K + K++ RE Sbjct: 21 QSPYTVQRFISSGSYGAVCAGVDSE-GIPVAIKRVFNTVSDGRTVNILSDSFLCKRVLRE 79 Query: 82 IKILENLRGGPNIITLADIV---KDPVSRTPALVFEHVNNTDFKQLYQ----TLTDYDIR 134 I++L + PNI+ L DI ++P LV E + TD Q+ ++ I+ Sbjct: 80 IRLLNHF-HHPNILGLRDIFVHFEEPAMHKLYLVTELM-RTDLAQVIHDQRIVISPQHIQ 137 Query: 135 FYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVAS 194 ++MY IL L H G++HRD+ P N+++ ++ + + D+ LA V Sbjct: 138 YFMYHILLGLHVLHEAGVVHRDLHPGNILL-ADNNDITICDFNLAREDTADANKTHYVTH 196 Query: 195 RYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDL 254 R+++ PEL++ ++ + +DMWS GC++A M RK F G Y+QL +I +V+GT + Sbjct: 197 RWYRAPELVMQFKGFTKLVDMWSAGCVMAEMFNRKA-LFRGSTFYNQLNKIVEVVGTPKI 255 Query: 255 YDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT 314 D + + + L + W V + + P ALD + K+L ++ Q R++ Sbjct: 256 EDVVMFSSPSARDYLRNSLSNVPARAWTAVVPTAD-----PVALDLIAKMLEFNPQRRIS 310 Query: 315 AREAMEHPYFYTV 327 +A+ HPYF ++ Sbjct: 311 TEQALRHPYFESL 323 >4NIF-A nrPDB Length = 333 Score = 266 bits (681), Expect = 9e-72, Method: Composition-based stats. Identities = 86/346 (24%), Positives = 149/346 (43%), Gaps = 48/346 (13%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIIT 96 D Y + +G G YSE ++ N + VK++ K+ + EI+IL PNIIT Sbjct: 8 DGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSE-EIEILLRYGQHPNIIT 66 Query: 97 LADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCHSMGIM 153 L D+ D + LV E + + + ++ + F ++ I K ++Y HS G++ Sbjct: 67 LKDVYDD--GKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVV 124 Query: 154 HRDVKPHNVMIDHEHRK---LRLIDWGLAEFYH-PGQEYNVRVASRYFKGPELLVDYQMY 209 HRD+KP N++ E LR+ D+G A+ + F PE+L Q Y Sbjct: 125 HRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVL-KRQGY 183 Query: 210 DYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRF 269 D D+WSLG +L +M+ PF +G + + Sbjct: 184 DEGCDIWSLGILLYTMLAGYTPFANGPSDTPE---------------------------- 215 Query: 270 NDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 329 +IL R ++ + N + VS A D + K+L D RLTA++ ++HP+ V Sbjct: 216 -EILTRIGSGKFT--LSGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPW----VT 268 Query: 330 DQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLGPLAGSPVIAA 375 + ++ S + + M + S++ + P L P+ ++ Sbjct: 269 QKDKLPQSQLSHQDLQLVKGAMAATYSALNSSKPTPQL--KPIESS 312 >3SOA-A nrPDB Length = 444 Score = 266 bits (680), Expect = 1e-71, Method: Composition-based stats. Identities = 71/300 (23%), Positives = 133/300 (44%), Gaps = 49/300 (16%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVV-----KILKPVKKKKIKREIKILENLRGG 91 ++YQL +LG+G +S V + + ++ K L +K++RE +I L+ Sbjct: 11 EEYQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDHQKLEREARICRLLKH- 69 Query: 92 PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCH 148 PNI+ L D + + L+F+ V + + + ++ D + +IL+A+ +CH Sbjct: 70 PNIVRLHDSISEEGHH--YLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCH 127 Query: 149 SMGIMHRDVKPHNVMIDH--EHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLVD 205 MG++HR++KP N+++ + ++L D+GLA E Q + + + PE+L Sbjct: 128 QMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRK 187 Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIEL 265 Y +D+W+ G +L ++ PF+ + LY I + Sbjct: 188 -DPYGKPVDLWACGVILYILLVGYPPFWDEDQH--------------RLYQQIKAGAYDF 232 Query: 266 DPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFY 325 S V+PEA D ++K+L + R+TA EA++HP+ Sbjct: 233 P--------------------SPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWIS 272 >2JC6-A nrPDB Length = 334 Score = 265 bits (678), Expect = 2e-71, Method: Composition-based stats. Identities = 73/310 (23%), Positives = 131/310 (42%), Gaps = 51/310 (16%) Query: 24 WDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPV----KKKKIK 79 W ++ ++ ++ LG G +SEV A + VK + K+ I+ Sbjct: 13 WKKQAEDIKKI----FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIE 68 Query: 80 REIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTD-FKQLYQT--LTDYDIRFY 136 EI +L ++ NI+ L DI + P LV + V+ + F ++ + T+ D Sbjct: 69 NEIAVLRKIKH-ENIVALEDIYESP--NHLYLVMQLVSGGELFDRIVEKGFYTEKDASTL 125 Query: 137 MYEILKALDYCHSMGIMHRDVKPHNVMI--DHEHRKLRLIDWGLAEFYHPGQEYNVRVAS 194 + ++L A+ Y H MGI+HRD+KP N++ E K+ + D+GL++ G + + Sbjct: 126 IRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGT 185 Query: 195 RYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDL 254 + PE+L + Y ++D WS+G + ++ PF+ +D+ L Sbjct: 186 PGYVAPEVLAQ-KPYSKAVDCWSIGVIAYILLCGYPPFYDENDS--------------KL 230 Query: 255 YDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT 314 ++ I K E D + +S A DF+ L+ D R T Sbjct: 231 FEQILKAEYEFDSPY--------------------WDDISDSAKDFIRNLMEKDPNKRYT 270 Query: 315 AREAMEHPYF 324 +A HP+ Sbjct: 271 CEQAARHPWI 280 >5G6V-A nrPDB Length = 324 Score = 265 bits (678), Expect = 2e-71, Method: Composition-based stats. Identities = 80/312 (25%), Positives = 165/312 (52%), Gaps = 22/312 (7%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK----KIKREIKILENLRGG 91 + Y + KLG G Y+ V++ + + V +K ++ ++ RE+ +L++L+ Sbjct: 1 METYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHA 60 Query: 92 PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY----QTLTDYDIRFYMYEILKALDYC 147 NI+TL DI+ ++ LVFE+++ D KQ + ++++ +++++L+ L YC Sbjct: 61 -NIVTLHDIIH--TEKSLTLVFEYLDK-DLKQYLDDCGNIINMHNVKLFLFQLLRGLAYC 116 Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH-PGQEYNVRVASRYFKGPELLVDY 206 H ++HRD+KP N++I+ E +L+L D+GLA P + Y+ V + +++ P++L+ Sbjct: 117 HRQKVLHRDLKPQNLLIN-ERGELKLADFGLARAKSIPTKTYDNEVVTLWYRPPDILLGS 175 Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 266 Y +DMW +GC+ M + P F G +QL I ++LGT + + E Sbjct: 176 TDYSTQIDMWGVGCIFYEMATGR-PLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEF 234 Query: 267 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYT 326 +N ++ + + + D L KLL+++ ++R++A +AM+HP+F + Sbjct: 235 KTYN-------YPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLS 287 Query: 327 VVKDQARMGSSS 338 + + ++ ++ Sbjct: 288 LGERIHKLPDTT 299 >3GC0-A nrPDB Length = 329 Score = 265 bits (678), Expect = 2e-71, Method: Composition-based stats. Identities = 83/302 (27%), Positives = 154/302 (50%), Gaps = 25/302 (8%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK-----IKREIKILENLRGG 91 D Y+ + KLG G Y EV++AI+ NE V +K ++ +++ RE+ +L+ L+ Sbjct: 34 DRYRRITKLGEGTYGEVYKAIDTVTNETVAIKRIRLEHEEEGVPGTAIREVSLLKELQH- 92 Query: 92 PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYCH 148 NII L ++ + L+FE+ N D K+ ++ I+ ++Y+++ +++CH Sbjct: 93 RNIIELKSVIHH--NHRLHLIFEYAEN-DLKKYMDKNPDVSMRVIKSFLYQLINGVNFCH 149 Query: 149 SMGIMHRDVKPHNVMID----HEHRKLRLIDWGLAEFYH-PGQEYNVRVASRYFKGPELL 203 S +HRD+KP N+++ E L++ D+GLA + P +++ + + +++ PE+L Sbjct: 150 SRRCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQFTHEIITLWYRPPEIL 209 Query: 204 VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNI 263 + + Y S+D+WS+ C+ A M+ K P F G DQL +I +VLG D + + Sbjct: 210 LGSRHYSTSVDIWSIACIWAEMLM-KTPLFPGDSEIDQLFKIFEVLGLPDDTTWPG---V 265 Query: 264 ELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323 P + + K +R + + +L D R++A+ A+EHPY Sbjct: 266 TALPDWKQSFPKFRGKTLKRVLGALLDDEGLDLLT----AMLEMDPVKRISAKNALEHPY 321 Query: 324 FY 325 F Sbjct: 322 FS 323 >5WAX-A nrPDB Length = 310 Score = 264 bits (674), Expect = 6e-71, Method: Composition-based stats. Identities = 70/337 (20%), Positives = 136/337 (40%), Gaps = 41/337 (12%) Query: 35 NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK--KKIKREIKILENLRGGP 92 + D Y+LVR +G G + N + + V VK ++ +K + ++REI +LR P Sbjct: 9 DGDRYELVRDIGSGNFGVARLMRNRADGQLVAVKYIERGEKIDENVQREIINHRSLRH-P 67 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCHS 149 NII +++ P A+V E+ + + + ++ + RF+ +++ + YCHS Sbjct: 68 NIIRFKEVILTPT--HLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHS 125 Query: 150 MGIMHRDVKPHNVMIDHEHR-KLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQM 208 M + HRD+K N ++D +L++ D+G ++ + V + + PE+L+ + Sbjct: 126 MQVCHRDLKLENTLLDGSTAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEY 185 Query: 209 YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPR 268 D+WS G L M+ PF + + I ++LG + Sbjct: 186 DGKVADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRILGVQ---------------- 229 Query: 269 FNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVV 328 + +SPE D + ++ + +R+T E HP+F + Sbjct: 230 ----------------YSIPDYVHISPECQDLISRIFVANPATRITIPEIRNHPWFLKNL 273 Query: 329 KDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLG 365 S+ P M I + + + Sbjct: 274 PADLMDDSTMSKQYEEPEQPMQSMDEIMQILAEATIP 310 >2X4F-A nrPDB Length = 373 Score = 264 bits (674), Expect = 6e-71, Method: Composition-based stats. Identities = 79/334 (23%), Positives = 146/334 (43%), Gaps = 49/334 (14%) Query: 4 PVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDY---QLVRKLGRGKYSEVFEAINIT 60 PV S+ V+ P +D+ + G + + LG G++ +V + Sbjct: 53 PVKSKRTSALAVDIPAPPAPFDHRIVTAKQGAVNSFYTVSKTEILGGGRFGQVHKCEETA 112 Query: 61 NNEKVVVKILKP---VKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVN 117 K+ KI+K K+++K EI ++ L N+I L D + LV E+V+ Sbjct: 113 TGLKLAAKIIKTRGMKDKEEVKNEISVMNQLDHA-NLIQLYDAFESKND--IVLVMEYVD 169 Query: 118 NTDFKQLY----QTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVM-IDHEHRKLR 172 + LT+ D +M +I + + + H M I+H D+KP N++ ++ + ++++ Sbjct: 170 GGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQMYILHLDLKPENILCVNRDAKQIK 229 Query: 173 LIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPF 232 +ID+GLA Y P ++ V + F PE++ +Y + DMWS+G + ++ PF Sbjct: 230 IIDFGLARRYKPREKLKVNFGTPEFLAPEVV-NYDFVSFPTDMWSVGVIAYMLLSGLSPF 288 Query: 233 FHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHL 292 G ++ + L I RW+ + E Sbjct: 289 L-GDNDAETLNNIL-------------------------------ACRWD--LEDEEFQD 314 Query: 293 VSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYT 326 +S EA +F+ KLL + R++A EA++HP+ Sbjct: 315 ISEEAKEFISKLLIKEKSWRISASEALKHPWLSD 348 >1ZWS-A nrPDB Length = 288 Score = 263 bits (673), Expect = 8e-71, Method: Composition-based stats. Identities = 77/314 (24%), Positives = 138/314 (43%), Gaps = 53/314 (16%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP---------VKKKKIKREIKILE 86 +D Y + +LG G+++ V + + + K +K V +++I+RE+ IL Sbjct: 11 EDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILR 70 Query: 87 NLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKA 143 + N+ITL D+ ++ L+ E V+ + ++L++ + ++ +IL Sbjct: 71 QVLHH-NVITLHDVYENRTD--VVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDG 127 Query: 144 LDYCHSMGIMHRDVKPHNVMIDHEHR---KLRLIDWGLAEFYHPGQEYNVRVASRYFKGP 200 ++Y H+ I H D+KP N+M+ ++ ++LID+GLA G E+ + F P Sbjct: 128 VNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAP 187 Query: 201 ELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDK 260 E +V+Y+ DMWS+G + ++ PF G + L I V Sbjct: 188 E-IVNYEPLGLEADMWSIGVITYILLSGASPFL-GDTKQETLANITSV------------ 233 Query: 261 YNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAME 320 + + D F S A DF+ KLL + + RLT +EA+ Sbjct: 234 -SYDFDEEF--------------------FSHTSELAKDFIRKLLVKETRKRLTIQEALR 272 Query: 321 HPYFYTVVKDQARM 334 HP+ V QA + Sbjct: 273 HPWITPVDNQQAMV 286 >4FG9-A nrPDB Length = 320 Score = 263 bits (672), Expect = 1e-70, Method: Composition-based stats. Identities = 71/298 (23%), Positives = 132/298 (44%), Gaps = 47/298 (15%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK----KIKREIKILENLRGG 91 +D Y LG G +SEV A + + V +K + + ++ EI +L ++ Sbjct: 17 RDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMENEIAVLHKIKH- 75 Query: 92 PNIITLADIVKDPVSRTPALVFEHVNNTD-FKQLYQT--LTDYDIRFYMYEILKALDYCH 148 PNI+ L DI + L+ + V+ + F ++ + T+ D ++++L A+ Y H Sbjct: 76 PNIVALDDIYES--GGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLH 133 Query: 149 SMGIMHRDVKPHNVMIDH--EHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDY 206 +GI+HRD+KP N++ E K+ + D+GL++ PG + + + PE+L Sbjct: 134 DLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEVLAQ- 192 Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 266 + Y ++D WS+G + ++ PF+ +D L++ I K E D Sbjct: 193 KPYSKAVDCWSIGVIAYILLCGYPPFYDEND--------------AKLFEQILKAEYEFD 238 Query: 267 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 + +S A DF+ L+ D + R T +A++HP+ Sbjct: 239 SPY--------------------WDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWI 276 >5IG1-A nrPDB Length = 344 Score = 263 bits (671), Expect = 1e-70, Method: Composition-based stats. Identities = 67/291 (23%), Positives = 126/291 (43%), Gaps = 48/291 (16%) Query: 44 KLGRGKYSEVFEAINITNNEKVVVKIL-----KPVKKKKIKREIKILENLRGGPNIITLA 98 +G+G +S V +N E VK++ + + KIKREI I +L+ +I+++ Sbjct: 24 VIGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRSSEINKIKREIGICSSLQH-EHIVSMR 82 Query: 99 DIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCHSMGIMHR 155 +D LVFE+V+ + + + D M++IL AL +CHS I+HR Sbjct: 83 RAFRD--ESHFYLVFEYVSGGELFDEIVTRKFYNEKDASACMHQILSALQHCHSKNIIHR 140 Query: 156 DVKPHNVMIDHE--HRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSL 213 D+KP N+++ + + +++ D+GLA G Y + + PE++ YD ++ Sbjct: 141 DLKPENLLLASKDPNAPVKITDFGLAVIMEQGPTYFGFAGTPGYLSPEVIRRV-PYDTAV 199 Query: 214 DMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDIL 273 D+W+ G +L ++ PF+ D+ +I Sbjct: 200 DVWACGVILYILLVGYPPFWE-EDHQKLYAQI---------------------------- 230 Query: 274 GRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 K + S V+ A + + +L + + R T +E ++HP+ Sbjct: 231 -----KNCQYDFPSPEWDSVTTAAKELIKAMLEPNPKRRPTVQELLQHPWI 276 >2W4O-A nrPDB Length = 349 Score = 263 bits (671), Expect = 1e-70, Method: Composition-based stats. Identities = 76/293 (25%), Positives = 122/293 (41%), Gaps = 43/293 (14%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKR-EIKILENLRGGPNII 95 D +++ +LGRG S V+ + +K+LK KKI R EI +L L PNII Sbjct: 53 DFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKIVRTEIGVLLRLSH-PNII 111 Query: 96 TLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCHSMGI 152 L +I + P +LV E V + ++ D + +IL+A+ Y H GI Sbjct: 112 KLKEIFETPTE--ISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGI 169 Query: 153 MHRDVKPHNVMIDH--EHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYD 210 +HRD+KP N++ L++ D+GL++ + + PE+L Y Sbjct: 170 VHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGC-AYG 228 Query: 211 YSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFN 270 +DMWS+G + ++ EPF+ + RI Sbjct: 229 PEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILN----------------------- 265 Query: 271 DILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323 E + S VS A D + KL+ D + RLT +A++HP+ Sbjct: 266 ----------CEYYFISPWWDEVSLNAKDLVRKLIVLDPKKRLTTFQALQHPW 308 >3E3P-A nrPDB Length = 360 Score = 262 bits (670), Expect = 2e-70, Method: Composition-based stats. Identities = 89/350 (25%), Positives = 164/350 (46%), Gaps = 32/350 (9%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIK-REIKILENLR--GGP 92 D +Q+ R G+G + V + V +K K ++ + + RE++I+++L P Sbjct: 22 MDRFQVERMAGQGTFGTVQLGKEKSTGMSVAIK--KVIQDPRFRNRELQIMQDLAVLHHP 79 Query: 93 NIITLADIV-----KDPVSRTPALVFEHVNNTDFKQLYQTLTDYD-------IRFYMYEI 140 NI+ L +D +V E+V +T + + I+ +++++ Sbjct: 80 NIVQLQSYFYTLGERDRRDIYLNVVMEYVPDT-LHRCCRNYYRRQVAPPPILIKVFLFQL 138 Query: 141 LKALDYCH--SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFK 198 ++++ H S+ + HRD+KPHNV+++ L+L D+G A+ P + + SRY++ Sbjct: 139 IRSIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKLSPSEPNVAYICSRYYR 198 Query: 199 GPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYI 258 PEL+ Q Y ++D+WS+GC+ A M+ EP F G ++ QL I +VLG Sbjct: 199 APELIFGNQHYTTAVDIWSVGCIFAEMMLG-EPIFRGDNSAGQLHEIVRVLGCPS----- 252 Query: 259 DKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREA 318 + +L+P D+ +S+ V S++ + EA D L LL+Y + R+ EA Sbjct: 253 REVLRKLNPSHTDVDLYNSKGIPWSNVFSDHSLKDAKEAYDLLSALLQYLPEERMKPYEA 312 Query: 319 MEHPYFYTVVKDQARMGSSSMP-GGSTPVSSANMMSGISSVPTPSPLGPL 367 + HPYF D+ ++ +P P + V + + L Sbjct: 313 LCHPYF-----DELHDPATKLPNNKDLPEDLFRFLPNEIEVMSEAQKAKL 357 >5ES1-A nrPDB Length = 328 Score = 261 bits (667), Expect = 3e-70, Method: Composition-based stats. Identities = 67/314 (21%), Positives = 138/314 (43%), Gaps = 51/314 (16%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL-----KPVKKKKIKREIKILENLRGGP 92 +Y+L+R +G+G +++V A +I +V +KI+ P +K+ RE++I++ L P Sbjct: 16 NYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGL-NHP 74 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNT---DFKQLYQTLTDYDIRFYMYEILKALDYCHS 149 NI+ L ++++ +T LV E+ + D+ + + + + R +I+ A+ YCH Sbjct: 75 NIVKLFEVIE--TEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQ 132 Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMY 209 I+HRD+K N+++D E +++ D+G + + G + + S + PEL + Sbjct: 133 KNIVHRDLKAENLLLDAE-ANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYD 191 Query: 210 DYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRF 269 +D+WSLG +L +++ PF GH+ + R+ + KY + Sbjct: 192 GPEVDIWSLGVILYTLVSGSLPF-DGHNLKELRERVLR-----------GKYRVPF---- 235 Query: 270 NDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 329 +S + L + L + R T + M+ + + Sbjct: 236 ----------------------YMSTDCESILRRFLVLNPAKRCTLEQIMKDKWI-NIGY 272 Query: 330 DQARMGSSSMPGGS 343 + + + P Sbjct: 273 EGEELKPYTEPEED 286 >5XZW-A nrPDB Length = 471 Score = 261 bits (667), Expect = 4e-70, Method: Composition-based stats. Identities = 79/316 (25%), Positives = 133/316 (42%), Gaps = 58/316 (18%) Query: 32 EWGNQDDYQLV-RKLGRGKYSEVFEAINITNNEKVVVKILKPVKK----KKIKREIKILE 86 + G D+ ++ +G+G ++ V +AI T + VKI+ K + RE+++L+ Sbjct: 190 KTGIFKDFSIIDEVVGQGAFATVKKAIERTTGKTFAVKIISKRKVIGNMDGVTRELEVLQ 249 Query: 87 NLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQL---YQTLTDYDIRFYMYEILKA 143 L P I+ L +D S +V E V+ D + + + R +IL A Sbjct: 250 KL-NHPRIVRLKGFYEDTESY--YMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTA 306 Query: 144 LDYCHSMGIMHRDVKPHNVMIDHEHRK-LRLIDWGLAEFYHPGQEYNVRVASRYFKGPEL 202 + Y HSMGI HRD+KP N++I+ + +++ D+GLA+ G + + PE+ Sbjct: 307 IKYIHSMGISHRDLKPDNILIEQDDPVLVKITDFGLAKVQGNGSFMKTFCGTLAYVAPEV 366 Query: 203 LVD------------YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLG 250 + Y +DMWS+GC++ ++ PF DQL Sbjct: 367 IRGKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPF--SGSTQDQL-------- 416 Query: 251 TEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQ 310 Y I + + P +S EA DF+D LL+ D Sbjct: 417 ----YKQIGRGSYHEGP--------------------LKDFRISEEARDFIDSLLQVDPN 452 Query: 311 SRLTAREAMEHPYFYT 326 +R TA +A+ HP+ Sbjct: 453 NRSTAAKALNHPWIVD 468 >3F3Z-A nrPDB Length = 277 Score = 261 bits (667), Expect = 4e-70, Method: Composition-based stats. Identities = 74/295 (25%), Positives = 128/295 (43%), Gaps = 47/295 (15%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP---VKKKKIKREIKILENLRGGPNII 95 Y L +GRG + EV A+ + K + + K+EI+I+++L PNII Sbjct: 11 YTLENTIGRGSWGEVKIAVQKGTRIRRAAKKIPKYFVEDVDRFKQEIEIMKSL-DHPNII 69 Query: 96 TLADIVKDPVSRTPALVFEHVNNTDFKQ---LYQTLTDYDIRFYMYEILKALDYCHSMGI 152 L + +D LV E + + + + D M ++L A+ YCH + + Sbjct: 70 RLYETFEDNTD--IYLVMELCTGGELFERVVHKRVFRESDAARIMKDVLSAVAYCHKLNV 127 Query: 153 MHRDVKPHNVMI--DHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYD 210 HRD+KP N + D L+LID+GLA + PG+ +V + Y+ P++L Y Sbjct: 128 AHRDLKPENFLFLTDSPDSPLKLIDFGLAARFKPGKMMRTKVGTPYYVSPQVLEGL--YG 185 Query: 211 YSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFN 270 D WS G M+ ++ PF D+ + +++I + T D+++ Sbjct: 186 PECDEWSAGVMMYVLLCGYPPFSAPTDS-EVMLKIREGTFTFPEKDWLN----------- 233 Query: 271 DILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFY 325 VSP+A + +LL + R+T+ +A+EH +F Sbjct: 234 ----------------------VSPQAESLIRRLLTKSPKQRITSLQALEHEWFE 266 >2YCR-A nrPDB Length = 323 Score = 261 bits (666), Expect = 5e-70, Method: Composition-based stats. Identities = 79/345 (22%), Positives = 127/345 (36%), Gaps = 55/345 (15%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK-----------KIKREIKI 84 +D+Y + + LG G EV A +KV +KI+ K ++ EI+I Sbjct: 9 RDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEI 68 Query: 85 LENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEIL 141 L+ L P II + + + +V E + + + L + + Y Y++L Sbjct: 69 LKKL-NHPCIIKIKNFFD---AEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQML 124 Query: 142 KALDYCHSMGIMHRDVKPHNVMIDH--EHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKG 199 A+ Y H GI+HRD+KP NV++ E +++ D+G ++ + + Sbjct: 125 LAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLA 184 Query: 200 PELLVDYQ--MYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDY 257 PE+LV Y+ ++D WSLG +L + PF L D Sbjct: 185 PEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQV-------------SLKDQ 231 Query: 258 IDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTARE 317 I P E VS +ALD + KLL D ++R T E Sbjct: 232 ITSGKYNFIP--------------------EVWAEVSEKALDLVKKLLVVDPKARFTTEE 271 Query: 318 AMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPS 362 A+ HP+ + S ST S Sbjct: 272 ALRHPWLQDEDMKRKFQDLLSEENESTAKPQVLAQPSTSRKRPRE 316 >3GUB-A nrPDB Length = 295 Score = 260 bits (664), Expect = 9e-70, Method: Composition-based stats. Identities = 76/319 (23%), Positives = 142/319 (44%), Gaps = 53/319 (16%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP---------VKKKKIKREIKILEN 87 D Y +LG G+++ V + + + K +K V ++ I+RE+ IL+ Sbjct: 11 DYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKE 70 Query: 88 LRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKAL 144 ++ PN+ITL ++ ++ L+ E V + ++LT+ + ++ +IL + Sbjct: 71 IQH-PNVITLHEVYENKTD--VILIGELVAGGELFDFLAEKESLTEEEATEFLKQILNGV 127 Query: 145 DYCHSMGIMHRDVKPHNVMI---DHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPE 201 Y HS+ I H D+KP N+M+ + ++++ID+GLA G E+ + F PE Sbjct: 128 YYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAPE 187 Query: 202 LLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKY 261 +V+Y+ DMWS+G + ++ PF G + L ++ V Y++ D+Y Sbjct: 188 -IVNYEPLGLEADMWSIGVITYILLSGASPFL-GDTKQETLANVSAV-----NYEFEDEY 240 Query: 262 NIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEH 321 S A DF+ +LL D + R+T +++++H Sbjct: 241 ----------------------------FSNTSALAKDFIRRLLVKDPKKRMTIQDSLQH 272 Query: 322 PYFYTVVKDQARMGSSSMP 340 P+ QA + S P Sbjct: 273 PWIKPKDTQQALSSAWSHP 291 >3RP9-A nrPDB Length = 458 Score = 259 bits (663), Expect = 1e-69, Method: Composition-based stats. Identities = 94/410 (22%), Positives = 162/410 (39%), Gaps = 84/410 (20%) Query: 32 EWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL-----KPVKKKKIKREIKILE 86 +W D Y++ +G G Y V EA + V +K + + K+I REI IL Sbjct: 48 DWQIPDRYEIRHLIGTGSYGHVCEAYDKLEKRVVAIKKILRVFEDLIDCKRILREIAILN 107 Query: 87 NLRGGPNIITLADIV--KDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEIL 141 L +++ + DIV KD V + ++DFK+L++T LT+ I+ +Y +L Sbjct: 108 RL-NHDHVVKVLDIVIPKDVEKFDELYVVLEIADSDFKKLFRTPVYLTELHIKTLLYNLL 166 Query: 142 KALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFY------------------- 182 + Y HS GI+HRD+KP N +++ + +++ D+GLA Sbjct: 167 VGVKYVHSAGILHRDLKPANCLVNQDC-SVKVCDFGLARTVDYPENGNSQLPISPREDDM 225 Query: 183 ---------HPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFR----- 228 + ++ V +R+++ PEL++ + Y ++D+WS+GC+ A ++ Sbjct: 226 NLVTFPHTKNLKRQLTGHVVTRWYRAPELILLQENYTEAIDVWSIGCIFAELLNMIKENV 285 Query: 229 -----KEPFFHGHD--------------------NYDQLVRIAKVLGTEDLYDYIDKYNI 263 + P F G N DQL I +LGT D Sbjct: 286 AYHADRGPLFPGSSCFPLSPDQKAGNDFKFHTRGNRDQLNVIFNILGTPSEEDIEALEKE 345 Query: 264 ELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323 + R ERF S S +A+ L ++L ++ R+T E + HP+ Sbjct: 346 DAKRYIRIFPKREGTDLAERFPAS------SADAIHLLKRMLVFNPNKRITINECLAHPF 399 Query: 324 FYTVVKDQARMGSS---SMP-----GGSTPVSSANMMSGISSVPTPSPLG 365 F V + ++ +P P + I L Sbjct: 400 FKEVRIAEVETNATEKVRLPFNDWMNMDEPQLRYAFVKEIQRYHPEIQLP 449 >4BGQ-A nrPDB Length = 304 Score = 259 bits (663), Expect = 1e-69, Method: Composition-based stats. Identities = 87/301 (28%), Positives = 148/301 (49%), Gaps = 21/301 (6%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK-----KKKIKREIKILENLRG 90 + ++++ +G G Y V + + +E V +K K + K+ RE+K+L L+ Sbjct: 11 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 70 Query: 91 GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYC 147 NI+ L + + LVFE+V + L + + ++ Y+Y+++KA+ +C Sbjct: 71 -ENIVELKEAFRR--RGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWC 127 Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ--EYNVRVASRYFKGPELLVD 205 H I+HRD+KP N++I H + L+L D+G A G Y+ VA+R+++ PELL+ Sbjct: 128 HKNDIVHRDIKPENLLISH-NDVLKLCDFGFARNLSEGNNANYDEEVATRWYRSPELLLG 186 Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIEL 265 Y S+DMWS+GC+L + + P F G DQL I KVLG Y+ Sbjct: 187 A-PYGKSVDMWSVGCILGELSDGQ-PLFPGESEIDQLFTIQKVLGPLPSEQMKLFYS--- 241 Query: 266 DPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFY 325 +PRF+ + R + + +++ LD + LL+ D R + + HP F Sbjct: 242 NPRFHGL--RFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQ 299 Query: 326 T 326 T Sbjct: 300 T 300 >1PHK-A nrPDB Length = 298 Score = 259 bits (662), Expect = 1e-69, Method: Composition-based stats. Identities = 71/320 (22%), Positives = 134/320 (41%), Gaps = 57/320 (17%) Query: 34 GNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK------------KKKIKRE 81 G ++Y+ LGRG S V I+ ++ VKI+ ++ +E Sbjct: 14 GFYENYEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQELREATLKE 73 Query: 82 IKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ---TLTDYDIRFYMY 138 + IL + G PNII L D + + LVF+ + + TL++ + R M Sbjct: 74 VDILRKVSGHPNIIQLKDTYE--TNTFFFLVFDLMKKGELFDYLTEKVTLSEKETRKIMR 131 Query: 139 EILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFK 198 +L+ + H + I+HRD+KP N+++D + ++L D+G + PG++ + + Sbjct: 132 ALLEVICALHKLNIVHRDLKPENILLD-DDMNIKLTDFGFSCQLDPGEKLREVCGTPSYL 190 Query: 199 GPELLV-----DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTED 253 PE++ ++ Y +DMWS G ++ +++ PF+H Q++ + ++ Sbjct: 191 APEIIECSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPFWH----RKQMLMLRMIMSGN- 245 Query: 254 LYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRL 313 + W+ + S D + + L Q R Sbjct: 246 --------------------YQFGSPEWDDY---------SDTVKDLVSRFLVVQPQKRY 276 Query: 314 TAREAMEHPYFYTVVKDQAR 333 TA EA+ HP+F V ++ R Sbjct: 277 TAEEALAHPFFQQYVVEEVR 296 >4JG6-A nrPDB Length = 355 Score = 259 bits (662), Expect = 2e-69, Method: Composition-based stats. Identities = 80/349 (22%), Positives = 141/349 (40%), Gaps = 44/349 (12%) Query: 26 YESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKIL 85 + H D Y++ +G G YS I+ N + VKI+ K+ + EI+IL Sbjct: 24 QQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTE-EIEIL 82 Query: 86 ENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILK 142 PNIITL D+ D + +V E + + + ++ + ++ I K Sbjct: 83 LRYGQHPNIITLKDVYDD--GKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITK 140 Query: 143 ALDYCHSMGIMHRDVKPHNVMIDHEHRK---LRLIDWGLAEFYH-PGQEYNVRVASRYFK 198 ++Y H+ G++HRD+KP N++ E +R+ D+G A+ + F Sbjct: 141 TVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFV 200 Query: 199 GPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYI 258 PE+L + Q YD + D+WSLG +L +M+ PF +G D+ + Sbjct: 201 APEVL-ERQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPE----------------- 242 Query: 259 DKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREA 318 +IL R ++ + + VS A D + K+L D RLTA Sbjct: 243 ------------EILARIGSGKFS--LSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALV 288 Query: 319 MEHPYF--YTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLG 365 + HP+ + + + +++ + P P+G Sbjct: 289 LRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVG 337 >3ZDU-A nrPDB Length = 325 Score = 259 bits (662), Expect = 2e-69, Method: Composition-based stats. Identities = 76/298 (25%), Positives = 145/298 (48%), Gaps = 19/298 (6%) Query: 35 NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKI----KREIKILENLRG 90 + + Y+ + K+G G Y V + + + V +KI ++ + REIK L+ Sbjct: 1 SMEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQF-H 59 Query: 91 GPNIITLADIVKDPVSRTPALVFEHVNNT---DFKQLYQTLTDYDIRFYMYEILKALDYC 147 N++ L ++ + + LVFE +++T + + L +R Y+++IL+A+DY Sbjct: 60 HENLVNLIEVFRQK--KKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYL 117 Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFY-HPGQEYNVRVASRYFKGPELLVDY 206 HS I+HRD+KP N+++ +L D+G A PG Y+ VA+R+++ PEL++ Sbjct: 118 HSNNIIHRDIKPENILVSQSGIT-KLCDFGFARTLAAPGDIYDDEVATRWYRAPELVLKD 176 Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 266 Y +D+W+LGCM+ M P+ + D L +I VL +L ++ + Sbjct: 177 TSYGKPVDIWALGCMIIEMATG-NPYLPSSSDLDLLHKI--VLKVGNLSPHLQNIFSKSP 233 Query: 267 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 +L + + R + + L++ D + L+ D R+++ + + H YF Sbjct: 234 IFAGVVLPQVQHPKNARKKYPKLNGLLA----DIVHACLQIDPADRISSSDLLHHEYF 287 >5YKS-A nrPDB Length = 377 Score = 259 bits (661), Expect = 2e-69, Method: Composition-based stats. Identities = 70/303 (23%), Positives = 130/303 (42%), Gaps = 50/303 (16%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKI-----KREIKILENLRGGPN 93 Y L + LGRG ++ V A ++ EKV VK++ K + +E++ ++ L PN Sbjct: 37 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMK-LVQHPN 95 Query: 94 IITLADIVKDPVSRTPALVFEHVNNTDFKQLY----QTLTDYDIRFYMYEILKALDYCHS 149 I+ L +++ L+ E + D + L + + Y +I+ A+ YCH Sbjct: 96 IVRLYEVIDTQT--KLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHK 153 Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMY 209 + ++HRD+KP NV+ + ++L D+G + + PG++ S + PE+L+ + Sbjct: 154 LHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYD 213 Query: 210 DYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRF 269 ++D+WSLG +L ++ + PF +D+ + L I T + Sbjct: 214 APAVDIWSLGVILFMLVCGQPPFQEANDS-ETLTMIMDCKYTVPSH-------------- 258 Query: 270 NDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 329 VS E D + ++L+ D + R + E HP+ V Sbjct: 259 -----------------------VSKECKDLITRMLQRDPKRRASLEEIENHPWLQGVDP 295 Query: 330 DQA 332 A Sbjct: 296 SPA 298 >3N9X-A nrPDB Length = 432 Score = 259 bits (661), Expect = 2e-69, Method: Composition-based stats. Identities = 86/364 (23%), Positives = 160/364 (43%), Gaps = 70/364 (19%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPV-----KKKKIKREIKILENLRG 90 D+Y + +GRG Y V+ A + + V +K + + K+I REI IL L+ Sbjct: 25 PDNYIIKHLIGRGSYGYVYLAYDKNTEKNVAIKKVNRMFEDLIDCKRILREITILNRLKS 84 Query: 91 GPNIITLAD-IVKDPV--SRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKAL 144 II L D I+ D + +V E + ++D K+L++T LT+ I+ +Y +L Sbjct: 85 D-YIIRLYDLIIPDDLLKFDELYIVLE-IADSDLKKLFKTPIFLTEEHIKTILYNLLLGE 142 Query: 145 DYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ------------------ 186 ++ H GI+HRD+KP N +++ + +++ D+GLA + + Sbjct: 143 NFIHESGIIHRDLKPANCLLNQDC-SVKVCDFGLARTINSEKDTNIVNDLEENEEPGPHN 201 Query: 187 -----EYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMI----------FRKEP 231 + V +R+++ PEL++ + Y S+D+WS GC+ A ++ + P Sbjct: 202 KNLKKQLTSHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAELLNMLQSHINDPTNRFP 261 Query: 232 FFHG-----------------HDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILG 274 F G N DQL I ++GT D + E+ Sbjct: 262 LFPGSSCFPLSPDRNSKKVHEKSNRDQLNIIFNIIGTPTEDDLKNINKPEVIKYIKLFPH 321 Query: 275 RHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARM 334 R +++ +S + ++ L+ +L+++ R+T +A++HPY V K + Sbjct: 322 RKPINLKQKYPS------ISDDGINLLESMLKFNPNKRITIDQALDHPYLKDVRKKKLEN 375 Query: 335 GSSS 338 S+ Sbjct: 376 FSTK 379 >3MN3-A nrPDB Length = 271 Score = 258 bits (660), Expect = 2e-69, Method: Composition-based stats. Identities = 75/296 (25%), Positives = 131/296 (44%), Gaps = 50/296 (16%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL------KPVKKKKIKREIKILENLRGG 91 +YQ+V+ LG G + +V A + T +KV +KI+ K + +I+REI L LR Sbjct: 5 NYQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRH- 63 Query: 92 PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ--TLTDYDIRFYMYEILKALDYCHS 149 P+II L D++K +V E+ N F + Q +++ + R + +I+ A++YCH Sbjct: 64 PHIIKLYDVIKSKDE--IIMVIEYAGNELFDYIVQRDKMSEQEARRFFQQIISAVEYCHR 121 Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMY 209 I+HRD+KP N+++D EH +++ D+GL+ G S + PE++ Sbjct: 122 HKIVHRDLKPENLLLD-EHLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKLYA 180 Query: 210 DYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRF 269 +D+WS G +L M+ R+ PF L+ I L Sbjct: 181 GPEVDVWSCGVILYVMLCRRLPFDDES--------------IPVLFKNISNGVYTLP--- 223 Query: 270 NDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFY 325 +SP A + ++L + +R++ E M+ +F Sbjct: 224 ---------------------KFLSPGAAGLIKRMLIVNPLNRISIHEIMQDDWFK 258 >3NIE-A nrPDB Length = 429 Score = 258 bits (660), Expect = 3e-69, Method: Composition-based stats. Identities = 91/382 (23%), Positives = 166/382 (43%), Gaps = 72/382 (18%) Query: 21 REYWDYESHVVE-WGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPV-----K 74 RE ++ +++ D+Y++ +GRG Y V+ A + N+ V +K + + Sbjct: 11 RENLYFQGAIIKNVKVPDNYEIKHLIGRGSYGYVYLAYDKNANKNVAIKKVNRMFEDLID 70 Query: 75 KKKIKREIKILENLRGGPNIITLADIV--KDPVSRTPALVFEHVNNTDFKQLYQT---LT 129 K+I REI IL L+ II L D++ +D + + + ++D K+L++T LT Sbjct: 71 CKRILREITILNRLKSD-YIIRLHDLIIPEDLLKFDELYIVLEIADSDLKKLFKTPIFLT 129 Query: 130 DYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ--- 186 + ++ +Y +L + H GI+HRD+KP N +++ + +++ D+GLA + + Sbjct: 130 EQHVKTILYNLLLGEKFIHESGIIHRDLKPANCLLNQDC-SVKICDFGLARTINSDKDIH 188 Query: 187 -----------------------EYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLA 223 + V +R+++ PEL++ + Y S+D+WS GC+ A Sbjct: 189 IVNDLEEKEENEEPGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDIWSTGCIFA 248 Query: 224 SMI----------FRKEPFFHG-----------------HDNYDQLVRIAKVLGTEDLYD 256 ++ + P F G N DQL I V+GT D Sbjct: 249 ELLNMMKSHINNPTNRFPLFPGSSCFPLSPDHNSKKVHEKSNRDQLNIIFNVIGTPPEED 308 Query: 257 YIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAR 316 E+ R + S+ +S E +D L+ +LR++ Q R+T Sbjct: 309 LKCITKQEVIKYIKLFPTR------DGIDLSKKYSSISKEGIDLLESMLRFNAQKRITID 362 Query: 317 EAMEHPYFYTVVKDQARMGSSS 338 +A+ HPY V K+ S+ Sbjct: 363 KALSHPYLKDVRKENLENFSTE 384 >3I6U-A nrPDB Length = 419 Score = 257 bits (657), Expect = 6e-69, Method: Composition-based stats. Identities = 75/318 (23%), Positives = 124/318 (38%), Gaps = 55/318 (17%) Query: 27 ESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK---------- 76 + V +D+Y + + LG G EV A +KV ++I+ K Sbjct: 125 DQSVYPKALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSAREADPA 184 Query: 77 -KIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYD 132 ++ EI+IL+ L P II + + + +V E + + + L + Sbjct: 185 LNVETEIEILKKL-NHPCIIKIKNFFD---AEDYYIVLELMEGGELFDKVVGNKRLKEAT 240 Query: 133 IRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDH--EHRKLRLIDWGLAEFYHPGQEYNV 190 + Y Y++L A+ Y H GI+HRD+KP NV++ E +++ D+G ++ Sbjct: 241 CKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRT 300 Query: 191 RVASRYFKGPELLVDYQ--MYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKV 248 + + PE+LV Y+ ++D WSLG +L + PF Sbjct: 301 LCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQV--------- 351 Query: 249 LGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYD 308 L D I P E VS +ALD + KLL D Sbjct: 352 ----SLKDQITSGKYNFIP--------------------EVWAEVSEKALDLVKKLLVVD 387 Query: 309 HQSRLTAREAMEHPYFYT 326 ++R T EA+ HP+ Sbjct: 388 PKARFTTEEALRHPWLQD 405 >3UC3-A nrPDB Length = 361 Score = 257 bits (657), Expect = 6e-69, Method: Composition-based stats. Identities = 73/338 (21%), Positives = 135/338 (39%), Gaps = 45/338 (13%) Query: 35 NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK--KKKIKREIKILENLRGGP 92 + D Y V+ +G G + + E V VK ++ + ++REI +LR P Sbjct: 18 DSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGAAIDENVQREIINHRSLRH-P 76 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCHS 149 NI+ +++ P A++ E+ + + + ++ + RF+ ++L + YCHS Sbjct: 77 NIVRFKEVILTPT--HLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHS 134 Query: 150 MGIMHRDVKPHNVMID-HEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQM 208 M I HRD+K N ++D +L++ D+G ++ + V + + PE+L+ + Sbjct: 135 MQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEY 194 Query: 209 YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPR 268 D+WS G L M+ PF + D I ++L KY+I D R Sbjct: 195 DGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSV--------KYSIPDDIR 246 Query: 269 FNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVV 328 +SPE + ++ D +R++ E H +F + Sbjct: 247 ------------------------ISPECCHLISRIFVADPATRISIPEIKTHSWFLKNL 282 Query: 329 KDQARMGSSSMPGGSTP----VSSANMMSGISSVPTPS 362 S++ P S +M IS P+ Sbjct: 283 PADLMNESNTGSQFQEPEQPMQSLDTIMQIISEATIPA 320 >2JAM-A nrPDB Length = 304 Score = 257 bits (656), Expect = 6e-69, Method: Composition-based stats. Identities = 67/297 (22%), Positives = 124/297 (41%), Gaps = 47/297 (15%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPV---KKKKIKREIKILENLRGGP 92 + + + LG G +SEVF + +K +K + ++ EI +L+ ++ Sbjct: 8 RKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDSSLENEIAVLKKIKH-E 66 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCHS 149 NI+TL DI + LV + V+ + T+ D + ++L A+ Y H Sbjct: 67 NIVTLEDIYESTTHY--YLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHE 124 Query: 150 MGIMHRDVKPHNVMI--DHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQ 207 GI+HRD+KP N++ E+ K+ + D+GL++ G + + + PE+L + Sbjct: 125 NGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNG-IMSTACGTPGYVAPEVLAQ-K 182 Query: 208 MYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDP 267 Y ++D WS+G + ++ PF+ ++ L++ I + E + Sbjct: 183 PYSKAVDCWSIGVITYILLCGYPPFYEETES--------------KLFEKIKEGYYEFES 228 Query: 268 RFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 F +S A DF+ LL D R T +A+ HP+ Sbjct: 229 PF--------------------WDDISESAKDFICHLLEKDPNERYTCEKALSHPWI 265 >3UTO-A nrPDB Length = 573 Score = 256 bits (655), Expect = 9e-69, Method: Composition-based stats. Identities = 75/361 (20%), Positives = 141/361 (39%), Gaps = 61/361 (16%) Query: 21 REYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL---KPVKKKK 77 ++Y+ + D Y + +LG G + V K + K+ Sbjct: 141 KQYYPQPVEIKHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKET 200 Query: 78 IKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQ----LYQTLTDYDI 133 +++EI+ + LR P ++ L D +D +++E ++ + + + +++ + Sbjct: 201 VRKEIQTMSVLRH-PTLVNLHDAFED--DNEMVMIYEFMSGGELFEKVADEHNKMSEDEA 257 Query: 134 RFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHE-HRKLRLIDWGLAEFYHPGQEYNVRV 192 YM ++ K L + H +H D+KP N+M + +L+LID+GL P Q V Sbjct: 258 VEYMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTT 317 Query: 193 ASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTE 252 + F PE+ + + Y DMWS+G + ++ PF G ++ + L + Sbjct: 318 GTAEFAAPEV-AEGKPVGYYTDMWSVGVLSYILLSGLSPF-GGENDDETLRNV------- 368 Query: 253 DLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSR 312 K + + +S + DF+ KLL D +R Sbjct: 369 --------------------------KSCDWNMDDSAFSGISEDGKDFIRKLLLADPNTR 402 Query: 313 LTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPT-----PSPLGPL 367 +T +A+EHP+ + PG + + S+ S+ T P PL PL Sbjct: 403 MTIHQALEHPWL----------TPGNAPGRDSQIPSSRYTKIRDSIKTKYDAWPEPLPPL 452 Query: 368 A 368 Sbjct: 453 G 453 >3TAC-A nrPDB Length = 361 Score = 256 bits (655), Expect = 1e-68, Method: Composition-based stats. Identities = 76/309 (24%), Positives = 129/309 (41%), Gaps = 57/309 (18%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK--------KKKIKREIKILEN 87 +D Y+L +G+G +S V IN ++ VKI+ K + +KRE I Sbjct: 25 EDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHM 84 Query: 88 LRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT-------LTDYDIRFYMYEI 140 L+ P+I+ L + +VFE ++ D ++ YM +I Sbjct: 85 LKH-PHIVELLETYSS--DGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQI 141 Query: 141 LKALDYCHSMGIMHRDVKPHNVMIDHEHRK--LRLIDWGLA-EFYHPGQEYNVRVASRYF 197 L+AL YCH I+HRDVKPH V++ + ++L +G+A + G RV + +F Sbjct: 142 LEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHF 201 Query: 198 KGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDY 257 PE++ + Y +D+W G +L ++ PF+ E L++ Sbjct: 202 MAPEVV-KREPYGKPVDVWGCGVILFILLSGCLPFYGTK---------------ERLFEG 245 Query: 258 IDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTARE 317 I K +++PR +S A D + ++L D R+T E Sbjct: 246 IIKGKYKMNPR--------------------QWSHISESAKDLVRRMLMLDPAERITVYE 285 Query: 318 AMEHPYFYT 326 A+ HP+ Sbjct: 286 ALNHPWLKE 294 >2Y7J-A nrPDB Length = 365 Score = 256 bits (655), Expect = 1e-68, Method: Composition-based stats. Identities = 71/308 (23%), Positives = 136/308 (44%), Gaps = 56/308 (18%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK-----------KKKIKREIKIL 85 Y +GRG S V ++ + VKI++ ++ +RE IL Sbjct: 94 QKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHIL 153 Query: 86 ENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ---TLTDYDIRFYMYEILK 142 + G P+IITL D + S LVF+ + + L++ + R M +L+ Sbjct: 154 RQVAGHPHIITLIDSYES--SSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLE 211 Query: 143 ALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPEL 202 A+ + H+ I+HRD+KP N+++D ++ ++RL D+G + PG++ + + PE+ Sbjct: 212 AVSFLHANNIVHRDLKPENILLD-DNMQIRLSDFGFSCHLEPGEKLRELCGTPGYLAPEI 270 Query: 203 LV-----DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDY 257 L + Y +D+W+ G +L +++ PF+H Q++ + ++ Sbjct: 271 LKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRR----QILMLRMIM-------- 318 Query: 258 IDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTARE 317 + + S W+ S D + +LL+ D ++RLTA + Sbjct: 319 -------------EGQYQFSSPEWDD---------RSSTVKDLISRLLQVDPEARLTAEQ 356 Query: 318 AMEHPYFY 325 A++HP+F Sbjct: 357 ALQHPFFE 364 >2QNJ-A nrPDB Length = 328 Score = 256 bits (655), Expect = 1e-68, Method: Composition-based stats. Identities = 63/303 (20%), Positives = 135/303 (44%), Gaps = 50/303 (16%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL-----KPVKKKKIKREIKILENLRGGP 92 +Y+L++ +G+G +++V A +I +V +KI+ P +K+ RE++I++ L P Sbjct: 13 NYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKIL-NHP 71 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNT---DFKQLYQTLTDYDIRFYMYEILKALDYCHS 149 NI+ L ++++ +T L+ E+ + D+ + + + + R +I+ A+ YCH Sbjct: 72 NIVKLFEVIE--TEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQ 129 Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMY 209 I+HRD+K N+++D + +++ D+G + + G + + S + PEL + Sbjct: 130 KRIVHRDLKAENLLLDAD-MNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYD 188 Query: 210 DYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRF 269 +D+WSLG +L +++ PF G + + R+ + KY I Sbjct: 189 GPEVDVWSLGVILYTLVSGSLPF-DGQNLKELRERVLR-----------GKYRIPF---- 232 Query: 270 NDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 329 +S + + L + L + R T + M+ + + Sbjct: 233 ----------------------YMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHE 270 Query: 330 DQA 332 + Sbjct: 271 EDE 273 >5KCV-A nrPDB Length = 460 Score = 256 bits (654), Expect = 1e-68, Method: Composition-based stats. Identities = 77/378 (20%), Positives = 144/378 (38%), Gaps = 70/378 (18%) Query: 5 VPSRARVYTDVNTHRPREYWDYESHVVEWGN------QDDYQLVRKLGRGKYSEVFEAIN 58 + +A D + P + E V ++++ ++ LG+G + +V Sbjct: 124 LKKQAAAEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKE 183 Query: 59 ITNNEKVVVKILKPV------KKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALV 112 +KILK + E ++L+N R P + L + V Sbjct: 184 KATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH-PFLTALKYSFQ--THDRLCFV 240 Query: 113 FEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCHS-MGIMHRDVKPHNVMIDHEH 168 E+ N + + ++ RFY EI+ ALDY HS +++RD+K N+M+D + Sbjct: 241 MEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDG 300 Query: 169 RKLRLIDWGLAEF-YHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIF 227 +++ D+GL + G + + PE+L D Y ++D W LG ++ M+ Sbjct: 301 H-IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDND-YGRAVDWWGLGVVMYEMMC 358 Query: 228 RKEPFF-HGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVH 286 + PF+ H+ +L+ + ++ RF LG Sbjct: 359 GRLPFYNQDHEKLFELILMEEI-------------------RFPRTLG------------ 387 Query: 287 SENQHLVSPEALDFLDKLLRYDHQSRLT-----AREAMEHPYFYTVVKD---QARMGSSS 338 PEA L LL+ D + RL A+E M+H +F +V + ++ Sbjct: 388 --------PEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPF 439 Query: 339 MPGGSTPVSSANMMSGIS 356 P ++ + + Sbjct: 440 KPQVTSETDTRYFDEEFT 457 >3H4J-B nrPDB Length = 336 Score = 256 bits (654), Expect = 1e-68, Method: Composition-based stats. Identities = 67/303 (22%), Positives = 127/303 (41%), Gaps = 50/303 (16%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK------KIKREIKILENLRGGP 92 Y + LG G + +V A + +KV +K + K +++REI L+ LR P Sbjct: 11 YIIRETLGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREISYLKLLRH-P 69 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT--LTDYDIRFYMYEILKALDYCHSM 150 +II L D++ P +V E+ F + + +T+ + R + +I+ A++YCH Sbjct: 70 HIIKLYDVITTPTD--IVMVIEYAGGELFDYIVEKKRMTEDEGRRFFQQIICAIEYCHRH 127 Query: 151 GIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYD 210 I+HRD+KP N+++D ++ +++ D+GL+ G S + PE++ Sbjct: 128 KIVHRDLKPENLLLD-DNLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVINGKLYAG 186 Query: 211 YSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFN 270 +D+WS G +L M+ + PF +L+ ++ + Sbjct: 187 PEVDVWSCGIVLYVMLVGRLPFDDE--------------FIPNLFKKVNSCVYVMP---- 228 Query: 271 DILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKD 330 +SP A + +++ D R+T +E P+F + D Sbjct: 229 --------------------DFLSPGAQSLIRRMIVADPMQRITIQEIRRDPWFNVNLPD 268 Query: 331 QAR 333 R Sbjct: 269 YLR 271 >3ZUT-A nrPDB Length = 362 Score = 255 bits (652), Expect = 2e-68, Method: Composition-based stats. Identities = 63/342 (18%), Positives = 132/342 (38%), Gaps = 41/342 (11%) Query: 35 NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK--KKIKREIKILENLRGGP 92 + D Y+LV+ +G G + + +NE V VK ++ +K + +KREI +LR P Sbjct: 17 DSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRH-P 75 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCHS 149 NI+ +++ P A+V E+ + + + ++ + RF+ +++ + YCH+ Sbjct: 76 NIVRFKEVILTPT--HLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHA 133 Query: 150 MGIMHRDVKPHNVMID-HEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQM 208 M + HRD+K N ++D +L++ +G ++ + V + + PE+L+ + Sbjct: 134 MQVCHRDLKLENTLLDGSPAPRLKICAFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEY 193 Query: 209 YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPR 268 D+WS G L M+ PF + + I ++L + Sbjct: 194 DGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAI------------- 240 Query: 269 FNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVV 328 + +SPE + ++ D R++ E H +F + Sbjct: 241 -------------------PDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNL 281 Query: 329 KDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLGPLAGS 370 ++ + I + + + P Sbjct: 282 PADLMNDNTMTTQFDESDQPGQSIEEIMQIIAEATVPPAGTQ 323 >1KOA-A nrPDB Length = 491 Score = 254 bits (650), Expect = 3e-68, Method: Composition-based stats. Identities = 75/361 (20%), Positives = 141/361 (39%), Gaps = 61/361 (16%) Query: 21 REYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL---KPVKKKK 77 ++Y+ + D Y + +LG G + V K + K+ Sbjct: 35 KQYYPQPVEIKHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKET 94 Query: 78 IKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQ----LYQTLTDYDI 133 +++EI+ + LR P ++ L D +D +++E ++ + + + +++ + Sbjct: 95 VRKEIQTMSVLRH-PTLVNLHDAFED--DNEMVMIYEFMSGGELFEKVADEHNKMSEDEA 151 Query: 134 RFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHE-HRKLRLIDWGLAEFYHPGQEYNVRV 192 YM ++ K L + H +H D+KP N+M + +L+LID+GL P Q V Sbjct: 152 VEYMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTT 211 Query: 193 ASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTE 252 + F PE+ + + Y DMWS+G + ++ PF G ++ + L + Sbjct: 212 GTAEFAAPEV-AEGKPVGYYTDMWSVGVLSYILLSGLSPF-GGENDDETLRNV------- 262 Query: 253 DLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSR 312 K + + +S + DF+ KLL D +R Sbjct: 263 --------------------------KSCDWNMDDSAFSGISEDGKDFIRKLLLADPNTR 296 Query: 313 LTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPT-----PSPLGPL 367 +T +A+EHP+ + PG + + S+ S+ T P PL PL Sbjct: 297 MTIHQALEHPWL----------TPGNAPGRDSQIPSSRYTKIRDSIKTKYDAWPEPLPPL 346 Query: 368 A 368 Sbjct: 347 G 347 >2JDO-A nrPDB Length = 342 Score = 254 bits (650), Expect = 4e-68, Method: Composition-based stats. Identities = 71/341 (20%), Positives = 133/341 (39%), Gaps = 63/341 (18%) Query: 35 NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPV------KKKKIKREIKILENL 88 +D+ ++ LG+G + +V +KIL+ + E ++L+N Sbjct: 8 TMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNT 67 Query: 89 RGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALD 145 R P + L + V E+ N + + T+ RFY EI+ AL+ Sbjct: 68 RH-PFLTALKYAFQ--THDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALE 124 Query: 146 YCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF-YHPGQEYNVRVASRYFKGPELLV 204 Y HS +++RD+K N+M+D + +++ D+GL + G + + PE+L Sbjct: 125 YLHSRDVVYRDIKLENLMLDKDGH-IKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLE 183 Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPFF-HGHDNYDQLVRIAKVLGTEDLYDYIDKYNI 263 D Y ++D W LG ++ M+ + PF+ H+ +L+ + ++ Sbjct: 184 DND-YGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEI--------------- 227 Query: 264 ELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT-----AREA 318 +SPEA L LL+ D + RL A+E Sbjct: 228 ------------------------RFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEV 263 Query: 319 MEHPYFYTVVKD---QARMGSSSMPGGSTPVSSANMMSGIS 356 MEH +F ++ Q ++ P ++ V + + Sbjct: 264 MEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFT 304 >5KZ7-A nrPDB Length = 346 Score = 254 bits (648), Expect = 6e-68, Method: Composition-based stats. Identities = 67/311 (21%), Positives = 138/311 (44%), Gaps = 51/311 (16%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK-----KKIKREIKILENLRGGP 92 +Y+L++ +G+G +++V A +I ++V VKI+ + +K+ RE++I++ L P Sbjct: 34 NYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVL-NHP 92 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNT---DFKQLYQTLTDYDIRFYMYEILKALDYCHS 149 NI+ L ++++ +T LV E+ + D+ + + + + R +I+ A+ YCH Sbjct: 93 NIVKLFEVIE--TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQ 150 Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMY 209 I+HRD+K N+++D + +++ D+G + + G + + S + PEL + Sbjct: 151 KFIVHRDLKAENLLLDAD-MNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYD 209 Query: 210 DYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRF 269 +D+WSLG +L +++ PF G + + R+ + KY I Sbjct: 210 GPEVDVWSLGVILYTLVSGSLPF-DGQNLKELRERVLR-----------GKYRIPF---- 253 Query: 270 NDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 329 +S + + L K L + R T + M+ + V Sbjct: 254 ----------------------YMSTDCENLLKKFLILNPSKRGTLEQIMKDRWM-NVGH 290 Query: 330 DQARMGSSSMP 340 + + P Sbjct: 291 EDDELKPYVEP 301 >2HW6-A nrPDB Length = 307 Score = 254 bits (648), Expect = 7e-68, Method: Composition-based stats. Identities = 75/317 (23%), Positives = 131/317 (41%), Gaps = 42/317 (13%) Query: 36 QDDYQLV-RKLGRGKYSEVFEAINITNNEKVVVKILKPV---KKKKIKREIKILENLRGG 91 +D Y+L LG G Y++V A+++ N ++ VKI++ + ++ RE++ L +G Sbjct: 11 EDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGN 70 Query: 92 PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYCH 148 NI+ L + +D LVFE + Q + + + ++ ALD+ H Sbjct: 71 KNILELIEFFEDDTRF--YLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLH 128 Query: 149 SMGIMHRDVKPHNVMIDHEHRK--LRLIDWGLAEFYH--------PGQEYNVRVASRYFK 198 + GI HRD+KP N++ + + +++ D+ L E S + Sbjct: 129 TKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYM 188 Query: 199 GPELLV----DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDL 254 PE++ YD D+WSLG +L M+ PF GH D D Sbjct: 189 APEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFV-GHCGAD---------CGWDR 238 Query: 255 YDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT 314 + +L + K W +S EA D + KLL D + RL+ Sbjct: 239 GEVCRVCQNKLFESIQEGKYEFPDKDWAH---------ISSEAKDLISKLLVRDAKQRLS 289 Query: 315 AREAMEHPYFYTVVKDQ 331 A + ++HP+ ++ Sbjct: 290 AAQVLQHPWVQGQAPEK 306 >4PDS-A nrPDB Length = 347 Score = 253 bits (647), Expect = 7e-68, Method: Composition-based stats. Identities = 78/315 (24%), Positives = 132/315 (41%), Gaps = 58/315 (18%) Query: 32 EWGNQDDYQLV-RKLGRGKYSEVFEAINITNNEKVVVKILKPVKK----KKIKREIKILE 86 + G D+ ++ +G+G ++ V +AI T + VKI+ K + RE+++L+ Sbjct: 25 KTGIFKDFSIIDEVVGQGAFATVKKAIERTTGKTFSVKIISKRKVIGNMDGVTRELEVLQ 84 Query: 87 NLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQL---YQTLTDYDIRFYMYEILKA 143 L P I+ L +D S +V E V+ D + + + R +IL A Sbjct: 85 KL-NHPRIVRLKGFYEDTESY--YMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTA 141 Query: 144 LDYCHSMGIMHRDVKPHNVMIDHEHRK-LRLIDWGLAEFYHPGQEYNVRVASRYFKGPEL 202 + Y HSMGI HRD+KP N++I+ + +++ +GLA+ G + + PE+ Sbjct: 142 IKYIHSMGISHRDLKPDNILIEQDDPVLVKITAFGLAKVQGNGSFMKTFCGTLAYVAPEV 201 Query: 203 LVD------------YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLG 250 + Y +DMWS+GC++ ++ PF DQL Sbjct: 202 IRGKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPF--SGSTQDQL-------- 251 Query: 251 TEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQ 310 Y I + + P +S EA DF+D LL+ D Sbjct: 252 ----YKQIGRGSYHEGP--------------------LKDFRISEEARDFIDSLLQVDPN 287 Query: 311 SRLTAREAMEHPYFY 325 +R TA +A+ HP+ Sbjct: 288 NRSTAAKALNHPWIK 302 >2W96-B nrPDB Length = 306 Score = 253 bits (647), Expect = 8e-68, Method: Composition-based stats. Identities = 82/303 (27%), Positives = 143/303 (47%), Gaps = 29/303 (9%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK-----IKREIKILENLR--G 90 Y+ V ++G G Y V++A + + V +K ++ ++ RE+ +L L Sbjct: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGLPISTVREVALLRRLEAFE 64 Query: 91 GPNIITLADIV---KDPVSRTPALVFEHVNNTDFKQLYQT-----LTDYDIRFYMYEILK 142 PN++ L D+ + LVFEHV+ D + L I+ M + L+ Sbjct: 65 HPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQFLR 123 Query: 143 ALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPEL 202 LD+ H+ I+HRD+KP N+++ ++L D+GLA Y + V + +++ PE+ Sbjct: 124 GLDFLHANCIVHRDLKPENILVTS-GGTVKLADFGLARIYSYQMALDPVVVTLWYRAPEV 182 Query: 203 LVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYN 262 L+ Y +DMWS+GC+ A M FR++P F G+ DQL +I ++G D+ Sbjct: 183 LLQ-STYATPVDMWSVGCIFAEM-FRRKPLFCGNSEADQLGKIFDLIGLPPEDDW----- 235 Query: 263 IELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHP 322 PR + R R V S + A L+ +L ++ R++A A++H Sbjct: 236 ----PRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLE-MLTFNPHKRISAFRALQHS 290 Query: 323 YFY 325 Y + Sbjct: 291 YLH 293 >4O2Z-A nrPDB Length = 377 Score = 253 bits (646), Expect = 1e-67, Method: Composition-based stats. Identities = 81/339 (23%), Positives = 157/339 (46%), Gaps = 27/339 (7%) Query: 11 VYTDVNTHRPREYWDYESHVV---EWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVV 67 + P+ D++ + V + Y L++ LG G Y ++ EKV + Sbjct: 16 FQGNQELSVPKIVGDFKVYNVSGSPFEVPSKYTLLKILGMGAYGIACSCLDGDTGEKVSI 75 Query: 68 KILKPVKK-----KKIKREIKILENLRGGPNIITLADIV----KDPVSRTPALVFEHVNN 118 K + V + K++ REI ++ N++ + +I+ ++ S V + + Sbjct: 76 KKCRDVFRDVEDGKRVLREIDMMR-FFHHENLLNVVNILPPLKREYHSFEDVYVVTPLMD 134 Query: 119 TDFKQLYQT---LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLID 175 D + ++ L + +++++Y+IL+ L Y HS + HRD+KP N ++ + +L++ID Sbjct: 135 VDMNVVLRSRQVLEESHMQYFVYQILRGLKYLHSANVAHRDLKPAN-LVTNISCELKIID 193 Query: 176 WGLAEFYH-PGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFH 234 +GL+ P E V +R+++ PELL++ Y ++D+WS+GC+ A M + ++P F Sbjct: 194 FGLSRSVDVPYSELTDYVITRWYRPPELLLENTNYSTAVDIWSVGCIFAEM-YNRKPVFP 252 Query: 235 GHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVS 294 G + DQL IA+ +G + +E D + ++ Sbjct: 253 GRNTMDQLRMIAQHIGKPPASIVEHREALEKLNELPDGSLNIPKLVPGLAGNT------- 305 Query: 295 PEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQAR 333 E +DFL K+ D R TA + + HPY + ++ Sbjct: 306 -EGIDFLSKMWTLDPSKRPTAADMLAHPYLAHLHDEEDE 343 >4REW-A nrPDB Length = 540 Score = 253 bits (646), Expect = 1e-67, Method: Composition-based stats. Identities = 72/327 (22%), Positives = 128/327 (39%), Gaps = 54/327 (16%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK------KIKREIKILENLRGG 91 Y L LG G + +V + KV VKIL K + KI+REI+ L+ L Sbjct: 7 HYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLK-LFRH 65 Query: 92 PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCH 148 P+II L ++ P +V E+V+ + L + + R +IL +DYCH Sbjct: 66 PHIIKLYQVISTPSD--IFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCH 123 Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQM 208 ++HRD+KP NV++D H ++ D+GL+ G+ S + PE++ Sbjct: 124 RHMVVHRDLKPENVLLDA-HMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLY 182 Query: 209 YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPR 268 +D+WS G +L +++ PF H Sbjct: 183 AGPEVDIWSSGVILYALLCGTLPFDDDH-------------------------------- 210 Query: 269 FNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVV 328 + +K + ++ ++P + L +L+ D R + ++ EH +F Sbjct: 211 ----VPTLFKKICDGIFYT--PQYLNPSVISLLKHMLQVDPMKRASIKDIREHEWFKQ-- 262 Query: 329 KDQARMGSSSMPGGSTPVSSANMMSGI 355 D + P S+ + + + Sbjct: 263 -DLPKYLFPEDPSYSSTMIDDEALKEV 288 >3MV5-A nrPDB Length = 342 Score = 252 bits (644), Expect = 2e-67, Method: Composition-based stats. Identities = 72/342 (21%), Positives = 135/342 (39%), Gaps = 64/342 (18%) Query: 35 NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPV------KKKKIKREIKILENL 88 ++++ ++ LG+G + +V +KILK + E ++L+N Sbjct: 8 TMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNS 67 Query: 89 RGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALD 145 R P + L + V E+ N + + ++ RFY EI+ ALD Sbjct: 68 RH-PFLTALKYSFQ--THDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALD 124 Query: 146 YCHS-MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF-YHPGQEYNVRVASRYFKGPELL 203 Y HS +++RD+K N+M+D + +++ D+GL + G + + PE+L Sbjct: 125 YLHSEKNVVYRDLKLENLMLDKDGH-IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVL 183 Query: 204 VDYQMYDYSLDMWSLGCMLASMIFRKEPFF-HGHDNYDQLVRIAKVLGTEDLYDYIDKYN 262 D Y ++D W LG ++ M+ + PF+ H+ +L+ + ++ Sbjct: 184 EDND-YGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEI-------------- 228 Query: 263 IELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT-----ARE 317 RF LG PEA L LL+ D + RL A+E Sbjct: 229 -----RFPRTLG--------------------PEAKSLLSGLLKKDPKQRLGGGSEDAKE 263 Query: 318 AMEHPYFYTVVKD---QARMGSSSMPGGSTPVSSANMMSGIS 356 M+H +F +V + ++ P ++ + + Sbjct: 264 IMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFT 305 >1KOB-A nrPDB Length = 387 Score = 251 bits (641), Expect = 4e-67, Method: Composition-based stats. Identities = 79/365 (21%), Positives = 143/365 (39%), Gaps = 57/365 (15%) Query: 21 REYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK---PVKKKK 77 ++Y V + D Y ++ +LG G + V + V K + P+ K Sbjct: 35 KKYVPQPVEVKQGSVYDYYDILEELGSGAFGVVHRCVEKATGRVFVAKFINTPYPLDKYT 94 Query: 78 IKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ----TLTDYDI 133 +K EI I+ L P +I L D +D L+ E ++ + +++ ++ Sbjct: 95 VKNEISIMNQL-HHPKLINLHDAFEDKYE--MVLILEFLSGGELFDRIAAEDYKMSEAEV 151 Query: 134 RFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEH-RKLRLIDWGLAEFYHPGQEYNVRV 192 YM + + L + H I+H D+KP N+M + + +++ID+GLA +P + V Sbjct: 152 INYMRQACEGLKHMHEHSIVHLDIKPENIMCETKKASSVKIIDFGLATKLNPDEIVKVTT 211 Query: 193 ASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTE 252 A+ F PE +VD + + DMW++G + ++ PF G D+ + L + Sbjct: 212 ATAEFAAPE-IVDREPVGFYTDMWAIGVLGYVLLSGLSPF-AGEDDLETLQNV------- 262 Query: 253 DLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSR 312 KR + + VSPEA DF+ LL+ + + R Sbjct: 263 --------------------------KRCDWEFDEDAFSSVSPEAKDFIKNLLQKEPRKR 296 Query: 313 LTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLGPLAGSPV 372 LT +A+EHP+ ++ + S+ + P + Sbjct: 297 LTVHDALEHPWLK-----------GDHSNLTSRIPSSRYNKIRQKIKEKYADWPAPQPAI 345 Query: 373 IAAAN 377 AN Sbjct: 346 GRIAN 350 >1FOT-A nrPDB Length = 318 Score = 251 bits (640), Expect = 6e-67, Method: Composition-based stats. Identities = 64/317 (20%), Positives = 132/317 (41%), Gaps = 57/317 (17%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKR-----EIKILENLRGG 91 D+Q++R LG G + V + N +K+LK ++K+ + +++ ++ Sbjct: 6 QDFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTH 65 Query: 92 PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYCH 148 P II + +D ++ ++ +++ + L + + +FY E+ AL+Y H Sbjct: 66 PFIIRMWGTFQD--AQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYLH 123 Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQM 208 S I++RD+KP N+++D ++ +++ D+G A++ + + PE++ + Sbjct: 124 SKDIIYRDLKPENILLD-KNGHIKITDFGFAKYVPDVTY--TLCGTPDYIAPEVV-STKP 179 Query: 209 YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPR 268 Y+ S+D WS G ++ M+ PF+ + T Y+ I + P Sbjct: 180 YNKSIDWWSFGILIYEMLAGYTPFYDSN--------------TMKTYEKILNAELRFPPF 225 Query: 269 FNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRL-----TAREAMEHPY 323 FN+ + D L +L+ D RL + HP+ Sbjct: 226 FNE------------------------DVKDLLSRLITRDLSQRLGNLQNGTEDVKNHPW 261 Query: 324 FYTVVKDQARMGSSSMP 340 F VV ++ + P Sbjct: 262 FKEVVWEKLLSRNIETP 278 >5JZN-A nrPDB Length = 280 Score = 250 bits (638), Expect = 8e-67, Method: Composition-based stats. Identities = 69/300 (23%), Positives = 125/300 (41%), Gaps = 48/300 (16%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK----KIKREIKILENLRGGP 92 + Y++ R +G G ++ V E + + + +KI+K K + I+ E+ IL ++ P Sbjct: 19 ERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHMIQNEVSILRRVKH-P 77 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCHS 149 NI+ L + + P LV E V D T+ D +Y + A+ Y HS Sbjct: 78 NIVLLIEEMDVPTE--LYLVMELVKGGDLFDAITSTNKYTERDASGMLYNLASAIKYLHS 135 Query: 150 MGIMHRDVKPHNVMI---DHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDY 206 + I+HRD+KP N+++ + L+L D+GLA G Y V + + PE++ + Sbjct: 136 LNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIV-DGPLYTV-CGTPTYVAPEIIAET 193 Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 266 Y +D+W+ G + ++ PF D+ + L +D I ++ Sbjct: 194 -GYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVL------------FDQILMGQVDFP 240 Query: 267 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYT 326 + VS A + + +L D R +A + +EHP+ Sbjct: 241 SPY--------------------WDNVSDSAKELITMMLLVDVDQRFSAVQVLEHPWVND 280 >2HAK-A nrPDB Length = 328 Score = 250 bits (638), Expect = 9e-67, Method: Composition-based stats. Identities = 67/292 (22%), Positives = 137/292 (46%), Gaps = 26/292 (8%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL-----KPVKKKKIKREIKILENLRGGP 92 +Y+L + +G+G +++V A ++ +V VKI+ P +K+ RE++I++ L P Sbjct: 16 NYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKIL-NHP 74 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNT---DFKQLYQTLTDYDIRFYMYEILKALDYCHS 149 NI+ L ++++ +T LV E+ + D+ + + + + R +I+ A+ YCH Sbjct: 75 NIVKLFEVIE--TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQ 132 Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMY 209 I+HRD+K N+++D + +++ D+G + + G + + S + PEL + Sbjct: 133 KYIVHRDLKAENLLLDGD-MNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYD 191 Query: 210 DYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLY-----DYIDKYNIE 264 +D+WSLG +L +++ PF G + + R+ + Y + + K + Sbjct: 192 GPEVDVWSLGVILYTLVSGSLPF-DGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLV 250 Query: 265 LDPRFNDILGRHSRKRWERFVHSENQ-HLVSPEALDFLDKLLRYDHQSRLTA 315 L+P L + + RW H E + + DF + R+ Sbjct: 251 LNPIKRGSLEQIMKDRWMNVGHEEEELKPYTEPDPDF-------NDTKRIDI 295 >4CFH-A nrPDB Length = 493 Score = 250 bits (638), Expect = 1e-66, Method: Composition-based stats. Identities = 73/327 (22%), Positives = 128/327 (39%), Gaps = 54/327 (16%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK------KIKREIKILENLRGG 91 Y L LG G + +V + KV VKIL K + KI+REI+ L+ L Sbjct: 34 HYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLK-LFRH 92 Query: 92 PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCH 148 P+II L ++ P +V E+V+ + L + + R +IL +DYCH Sbjct: 93 PHIIKLYQVISTPSD--IFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCH 150 Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQM 208 ++HRD+KP NV++D H ++ D+GL+ G+ S + PE++ Sbjct: 151 RHMVVHRDLKPENVLLDA-HMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLY 209 Query: 209 YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPR 268 +D+WS G +L +++ PF H Sbjct: 210 AGPEVDIWSSGVILYALLCGTLPFDDDH-------------------------------- 237 Query: 269 FNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVV 328 + +K + ++ ++P + L +L+ D R T ++ EH +F Sbjct: 238 ----VPTLFKKICDGIFYT--PQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQ-- 289 Query: 329 KDQARMGSSSMPGGSTPVSSANMMSGI 355 D + P S+ + + + Sbjct: 290 -DLPKYLFPEDPSYSSTMIDDEALKEV 315 >4RED-A nrPDB Length = 351 Score = 250 bits (638), Expect = 1e-66, Method: Composition-based stats. Identities = 72/327 (22%), Positives = 127/327 (38%), Gaps = 54/327 (16%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK------KIKREIKILENLRGG 91 Y L LG G + +V + V VKIL K + KI+REI+ L+ L Sbjct: 15 HYILGDTLGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLDVVGKIRREIQNLK-LFRH 73 Query: 92 PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCH 148 P+II L ++ P +V E+V+ + L + + R +IL +DYCH Sbjct: 74 PHIIKLYQVISTPSD--IFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCH 131 Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQM 208 ++HRD+KP NV++D H ++ D+GL+ G+ S + PE++ Sbjct: 132 RHMVVHRDLKPENVLLDA-HMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLY 190 Query: 209 YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPR 268 +D+WS G +L +++ PF H Sbjct: 191 AGPEVDIWSSGVILYALLCGTLPFDDDH-------------------------------- 218 Query: 269 FNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVV 328 + +K + ++ ++P + L +L+ D R + ++ EH +F Sbjct: 219 ----VPTLFKKICDGIFYT--PQYLNPSVISLLKHMLQVDPMKRASIKDIREHEWFKQ-- 270 Query: 329 KDQARMGSSSMPGGSTPVSSANMMSGI 355 D + P ST + + + Sbjct: 271 -DLPKYLFPEDPSYSTTMIDDEALKEV 296 >4CFF-A nrPDB Length = 571 Score = 249 bits (636), Expect = 1e-66, Method: Composition-based stats. Identities = 72/298 (24%), Positives = 118/298 (39%), Gaps = 51/298 (17%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK------KIKREIKILENLRGG 91 Y L LG G + +V + KV VKIL K + KIKREI+ L+ L Sbjct: 34 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK-LFRH 92 Query: 92 PNIITLADIVKDPVSRTPALVFEHVNNTDFKQL---YQTLTDYDIRFYMYEILKALDYCH 148 P+II L ++ P +V E+V+ + + + + + R +IL A+DYCH Sbjct: 93 PHIIKLYQVISTPTDF--FMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCH 150 Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQM 208 ++HRD+KP NV++D H ++ D+GL+ G+ S + PE++ Sbjct: 151 RHMVVHRDLKPENVLLDA-HMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLY 209 Query: 209 YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPR 268 +D+WS G +L +++ PF H L+ I + Sbjct: 210 AGPEVDIWSCGVILYALLCGTLPFDDEH--------------VPTLFKKIRGGVFYIPEY 255 Query: 269 FNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYT 326 N + L +L+ D R T ++ EH +F Sbjct: 256 LNRSVAT------------------------LLMHMLQVDPLKRATIKDIREHEWFKQ 289 >5EZV-A nrPDB Length = 560 Score = 249 bits (636), Expect = 1e-66, Method: Composition-based stats. Identities = 72/298 (24%), Positives = 118/298 (39%), Gaps = 51/298 (17%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK------KIKREIKILENLRGG 91 Y L LG G + +V + KV VKIL K + KIKREI+ L+ L Sbjct: 29 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK-LFRH 87 Query: 92 PNIITLADIVKDPVSRTPALVFEHVNNTDFKQL---YQTLTDYDIRFYMYEILKALDYCH 148 P+II L ++ P +V E+V+ + + + + + R +IL A+DYCH Sbjct: 88 PHIIKLYQVISTPTDF--FMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCH 145 Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQM 208 ++HRD+KP NV++D H ++ D+GL+ G+ S + PE++ Sbjct: 146 RHMVVHRDLKPENVLLDA-HMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLY 204 Query: 209 YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPR 268 +D+WS G +L +++ PF H L+ I + Sbjct: 205 AGPEVDIWSCGVILYALLCGTLPFDDEH--------------VPTLFKKIRGGVFYIPEY 250 Query: 269 FNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYT 326 N + L +L+ D R T ++ EH +F Sbjct: 251 LNRSVAT------------------------LLMHMLQVDPLKRATIKDIREHEWFKQ 284 >5F9E-A nrPDB Length = 353 Score = 249 bits (636), Expect = 2e-66, Method: Composition-based stats. Identities = 76/367 (20%), Positives = 137/367 (37%), Gaps = 64/367 (17%) Query: 13 TDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP 72 ++N RP + +D++L + LG+G + +VF A N+ +K LK Sbjct: 3 PELNKERPS--------LQIKLKIEDFELHKMLGKGSFGKVFLAEFKKTNQFFAIKALKK 54 Query: 73 V------KKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ 126 + E ++L P + + + V E++N D Q Sbjct: 55 DVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQ--TKENLFFVMEYLNGGDLMYHIQ 112 Query: 127 ---TLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH 183 FY EI+ L + HS GI++RD+K N+++D + +++ D+G+ + Sbjct: 113 SCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGH-IKIADFGMCKENM 171 Query: 184 PGQ-EYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQL 242 G + N + + PE+L+ Q Y++S+D WS G +L M+ + PF HG D + Sbjct: 172 LGDAKTNEFCGTPDYIAPEILLG-QKYNHSVDWWSFGVLLYEMLIGQSPF-HGQDEEELF 229 Query: 243 VRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLD 302 I + PR+ + EA D L Sbjct: 230 HSIRM--------------DNPFYPRWLE-----------------------KEAKDLLV 252 Query: 303 KLLRYDHQSRLTAR-EAMEHPYFYTVVKDQA---RMGSSSMPGGSTPVSSANMMSGISSV 358 KL + + RL R + +HP F + ++ + P +P +N + Sbjct: 253 KLFVREPEKRLGVRGDIRQHPLFREINWEELERKEIDPPFRPKVKSPFDCSNFDKEFLNE 312 Query: 359 PTPSPLG 365 Sbjct: 313 KPRLSFA 319 >6C9D-A nrPDB Length = 459 Score = 249 bits (635), Expect = 2e-66, Method: Composition-based stats. Identities = 67/292 (22%), Positives = 137/292 (46%), Gaps = 26/292 (8%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL-----KPVKKKKIKREIKILENLRGGP 92 +Y+L + +G+G +++V A ++ +V VKI+ P +K+ RE++I++ L P Sbjct: 22 NYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKIL-NHP 80 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNT---DFKQLYQTLTDYDIRFYMYEILKALDYCHS 149 NI+ L ++++ +T LV E+ + D+ + + + + R +I+ A+ YCH Sbjct: 81 NIVKLFEVIE--TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQ 138 Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMY 209 I+HRD+K N+++D + +++ D+G + + G + + S + PEL + Sbjct: 139 KYIVHRDLKAENLLLDGD-MNIKIADFGFSNEFTVGNKLDEFCGSPPYAAPELFQGKKYD 197 Query: 210 DYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLY-----DYIDKYNIE 264 +D+WSLG +L +++ PF G + + R+ + Y + + K + Sbjct: 198 GPEVDVWSLGVILYTLVSGSLPF-DGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLV 256 Query: 265 LDPRFNDILGRHSRKRWERFVHSENQ-HLVSPEALDFLDKLLRYDHQSRLTA 315 L+P L + + RW H E + + DF + R+ Sbjct: 257 LNPIKRGSLEQIMKDRWMNVGHEEEELKPYTEPDPDF-------NDTKRIDI 301 >3D2K-A nrPDB Length = 272 Score = 249 bits (635), Expect = 2e-66, Method: Composition-based stats. Identities = 71/298 (23%), Positives = 132/298 (44%), Gaps = 53/298 (17%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK------IKREIKILENLRG 90 +D+ + R LG+GK+ V+ A + + +K+L + +K ++RE++I +LR Sbjct: 12 EDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVEHQLRREVEIQSHLRH 71 Query: 91 GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLT---DYDIRFYMYEILKALDYC 147 PNI+ L D L+ E+ + Q L+ + Y+ E+ AL YC Sbjct: 72 -PNILRLYGYFHDATR--VYLILEYAPLGTVYRELQKLSRFDEQRTATYITELANALSYC 128 Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQ 207 HS ++HRD+KP N+++ + +L++ D+G + + P + + PE++ + + Sbjct: 129 HSKRVIHRDIKPENLLLGS-NGELKIADFGWS-VHAPSSRRTTLCGTLDYLPPEMI-EGR 185 Query: 208 MYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDP 267 M+D +D+WSLG + + PF H + RI++V T + Sbjct: 186 MHDEKVDLWSLGVLCYEFLVGMPPF-EAHTYQETYRRISRVEFTFPDF------------ 232 Query: 268 RFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFY 325 V+ A D + +LL+++ RLT E +EHP+ Sbjct: 233 -------------------------VTEGARDLISRLLKHNASQRLTLAEVLEHPWIK 265 >3IS5-A nrPDB Length = 285 Score = 248 bits (634), Expect = 2e-66, Method: Composition-based stats. Identities = 61/303 (20%), Positives = 130/303 (42%), Gaps = 53/303 (17%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK----KKIKREIKILENLRGGP 92 D + RKLG G + +V ++ + V+K + + ++I+ EI++L++L P Sbjct: 22 DLFIFKRKLGSGAFGDVHLVEERSSGLERVIKTINKDRSQVPMEQIEAEIEVLKSL-DHP 80 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNTDFKQLY-------QTLTDYDIRFYMYEILKALD 145 NII + ++ +D +V E + + + L++ + M +++ AL Sbjct: 81 NIIKIFEVFEDY--HNMYIVMETCEGGELLERIVSAQARGKALSEGYVAELMKQMMNALA 138 Query: 146 YCHSMGIMHRDVKPHNVMI--DHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELL 203 Y HS ++H+D+KP N++ H +++ID+GLAE + + + + PE+ Sbjct: 139 YFHSQHVVHKDLKPENILFQDTSPHSPIKIIDFGLAELFKSDEHSTNAAGTALYMAPEVF 198 Query: 204 VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNI 263 + + D+WS G ++ ++ PF + +++ + Y + Sbjct: 199 --KRDVTFKCDIWSAGVVMYFLLTGCLPF--TGTSLEEVQQ--------KATYKEPNYAV 246 Query: 264 ELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323 E P ++P+A+D L ++L D + R +A + + H + Sbjct: 247 ECRP-------------------------LTPQAVDLLKQMLTKDPERRPSAAQVLHHEW 281 Query: 324 FYT 326 F Sbjct: 282 FKQ 284 >3UDB-A nrPDB Length = 317 Score = 248 bits (634), Expect = 3e-66, Method: Composition-based stats. Identities = 66/323 (20%), Positives = 129/323 (39%), Gaps = 49/323 (15%) Query: 35 NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK--KKIKREIKILENLRGGP 92 + D Y+LV+ +G G + + NE V VK ++ +K + +KREI +LR P Sbjct: 17 DSDRYELVKDIGAGNFGVARLMRDKQANELVAVKYIERGEKIDENVKREIINHRSLRH-P 75 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCHS 149 NI+ +++ P A+V E+ + + + ++ + RF+ +++ + Y H+ Sbjct: 76 NIVRFKEVILTPT--HLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYAHA 133 Query: 150 MGIMHRDVKPHNVMID-HEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQM 208 M + HRD+K N ++D +L++ D+G ++ + V + + PE+L+ + Sbjct: 134 MQVAHRDLKLENTLLDGSPAPRLKIADFGYSKASVLHSQPKSAVGTPAYIAPEVLLKKEY 193 Query: 209 YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPR 268 D+WS G L M+ PF + + I ++L + Sbjct: 194 DGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAI------------- 240 Query: 269 FNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF---- 324 + +SPE + ++ D R++ E H +F Sbjct: 241 -------------------PDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNL 281 Query: 325 -YTVVKDQARM---GSSSMPGGS 343 ++ D S PG S Sbjct: 282 PADLMNDNTMTTQFDESDQPGQS 304 >3KN6-A nrPDB Length = 325 Score = 248 bits (634), Expect = 3e-66, Method: Composition-based stats. Identities = 68/290 (23%), Positives = 129/290 (44%), Gaps = 36/290 (12%) Query: 43 RKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVK 102 + LG G +S + ++ +N+ VKI+ + ++EI L+ G PNI+ L ++ Sbjct: 17 KPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALKLCEGHPNIVKLHEVFH 76 Query: 103 DPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYCHSMGIMHRDVKP 159 D + LV E +N + + + ++ + + M +++ A+ + H +G++HRD+KP Sbjct: 77 DQL--HTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLKP 134 Query: 160 HNVMID--HEHRKLRLIDWGLAEFYHPGQE-YNVRVASRYFKGPELLVDYQMYDYSLDMW 216 N++ +++ ++++ID+G A P + + ++ PELL + YD S D+W Sbjct: 135 ENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELL-NQNGYDESCDLW 193 Query: 217 SLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRH 276 SLG +L +M+ + PF HD + L + + K Sbjct: 194 SLGVILYTMLSGQVPF-QSHD---------RSLTCTSAVEIMKKI--------------- 228 Query: 277 SRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYT 326 K+ + E VS EA D + LL D RL + + Sbjct: 229 --KKGDFSFEGEAWKNVSQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQD 276 >3EB0-A nrPDB Length = 383 Score = 247 bits (632), Expect = 4e-66, Method: Composition-based stats. Identities = 92/369 (24%), Positives = 164/369 (44%), Gaps = 58/369 (15%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITL 97 Y L + LG G + V E +I + ++ +K + + K RE+ I++ L NII L Sbjct: 8 KYSLGKTLGTGSFGIVCEVFDIESGKRFALKKVLQDPRYK-NRELDIMKVL-DHVNIIKL 65 Query: 98 ADIVKDPVS------------------------------------RTPALVFEHVNNT-- 119 D + ++ E+V +T Sbjct: 66 VDYFYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNVIMEYVPDTLH 125 Query: 120 ----DFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLID 175 F + +++ I Y+Y++ +A+ + HS+GI HRD+KP N++++ + L+L D Sbjct: 126 KVLKSFIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLLVNSKDNTLKLCD 185 Query: 176 WGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHG 235 +G A+ P + + SR+++ PEL++ Y S+D+WS+GC+ +I K P F G Sbjct: 186 FGSAKKLIPSEPSVAYICSRFYRAPELMLGATEYTPSIDLWSIGCVFGELILGK-PLFSG 244 Query: 236 HDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSP 295 + DQLVRI +++GT I + RF + K W + + L Sbjct: 245 ETSIDQLVRIIQIMGTPTKEQMIRMNPHYTEVRFPTLKA----KDWRKILPEGTPSL--- 297 Query: 296 EALDFLDKLLRYDHQSRLTAREAMEHPYFYTVV---KDQARMGSSSMPGGST--PVSSAN 350 A+D L+++LRY+ R+ EAM HP+F + + + + S+ G + P Sbjct: 298 -AIDLLEQILRYEPDLRINPYEAMAHPFFDHLRNSYESEVKNNSNFPHGVNQNIPQLFNF 356 Query: 351 MMSGISSVP 359 +S +P Sbjct: 357 SPYELSIIP 365 >4UZD-A nrPDB Length = 287 Score = 246 bits (629), Expect = 9e-66, Method: Composition-based stats. Identities = 70/297 (23%), Positives = 132/297 (44%), Gaps = 53/297 (17%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK------IKREIKILENLRG 90 +D+++ R LG+GK+ V+ A + + +K+L + +K ++RE++I +LR Sbjct: 8 EDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRH 67 Query: 91 GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLT---DYDIRFYMYEILKALDYC 147 PNI+ L D L+ E+ + Q L+ + Y+ E+ AL YC Sbjct: 68 -PNILRLYGYFHDATR--VYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYC 124 Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQ 207 HS ++HRD+KP N+++ +L++ D+G + + P + + PE++ + + Sbjct: 125 HSKRVIHRDIKPENLLLGSAG-ELKIADFGWS-VHAPSSRRTTLCGTLDYLPPEMI-EGR 181 Query: 208 MYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDP 267 M+D +D+WSLG + + K PF + + RI++V T + Sbjct: 182 MHDEKVDLWSLGVLCYEFLVGKPPF-EANTYQETYKRISRVEFTFPDF------------ 228 Query: 268 RFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 V+ A D + +LL+++ R RE +EHP+ Sbjct: 229 -------------------------VTEGARDLISRLLKHNPSQRPMLREVLEHPWI 260 >2YZA-A nrPDB Length = 276 Score = 246 bits (629), Expect = 9e-66, Method: Composition-based stats. Identities = 72/298 (24%), Positives = 118/298 (39%), Gaps = 51/298 (17%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK------KIKREIKILENLRGG 91 Y L LG G + +V + KV VKIL K + KIKREI+ L+ L Sbjct: 12 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK-LFRH 70 Query: 92 PNIITLADIVKDPVSRTPALVFEHVNNTDFKQL---YQTLTDYDIRFYMYEILKALDYCH 148 P+II L ++ P +V E+V+ + + + + + R +IL A+DYCH Sbjct: 71 PHIIKLYQVISTPTDF--FMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCH 128 Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQM 208 ++HRD+KP NV++D H ++ D+GL+ G+ S + PE++ Sbjct: 129 RHMVVHRDLKPENVLLDA-HMNAKIADFGLSNMMSDGEFLRDSCGSPNYAAPEVISGRLY 187 Query: 209 YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPR 268 +D+WS G +L +++ PF H L+ I + Sbjct: 188 AGPEVDIWSCGVILYALLCGTLPFDDEH--------------VPTLFKKIRGGVFYIPEY 233 Query: 269 FNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYT 326 N + L +L+ D R T ++ EH +F Sbjct: 234 LNRSVAT------------------------LLMHMLQVDPLKRATIKDIREHEWFKQ 267 >5D9K-A nrPDB Length = 330 Score = 246 bits (628), Expect = 1e-65, Method: Composition-based stats. Identities = 72/349 (20%), Positives = 137/349 (39%), Gaps = 63/349 (18%) Query: 32 EWGNQDDYQLVRKLGRGKYSEVFEAINITNN---EKVVVKILKPV-----KKKKIKREIK 83 E + ++L++ LG+G + +VF I+ + + +K+LK + + K E Sbjct: 25 EKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERD 84 Query: 84 ILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEI 140 IL + P I+ L + L+ + + D T+ D++FY+ E+ Sbjct: 85 ILVEV-NHPFIVKLHYAFQ--TEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAEL 141 Query: 141 LKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF-YHPGQEYNVRVASRYFKG 199 ALD+ HS+GI++RD+KP N+++D E ++L D+GL++ ++ + + Sbjct: 142 ALALDHLHSLGIIYRDLKPENILLDEEGH-IKLTDFGLSKESIDHEKKAYSFCGTVEYMA 200 Query: 200 PELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYID 259 PE++ + + + S D WS G ++ M+ PF G D + + I K Sbjct: 201 PEVV-NRRGHTQSADWWSFGVLMFEMLTGTLPF-QGKDRKETMTMILK------------ 246 Query: 260 KYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTA---- 315 +SPEA L L + + +RL A Sbjct: 247 -------------------------AKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDG 281 Query: 316 -REAMEHPYFYTVVKDQA---RMGSSSMPGGSTPVSSANMMSGISSVPT 360 E H +F T+ ++ + P P + ++ Sbjct: 282 VEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTP 330 >5ZTN-A nrPDB Length = 429 Score = 245 bits (626), Expect = 2e-65, Method: Composition-based stats. Identities = 77/322 (23%), Positives = 152/322 (47%), Gaps = 40/322 (12%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK--KKIKREIKILENLR-----G 90 Y++++ +G+G + +V +A + ++ V +K+++ K+ ++ EI+ILE+LR Sbjct: 98 RYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDN 157 Query: 91 GPNIITLADIVKDPVSRTPALVFEHVNNTDF----KQLYQTLTDYDIRFYMYEILKALDY 146 N+I + + + FE ++ + K +Q + +R + + IL+ LD Sbjct: 158 TMNVIHMLENFT--FRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDA 215 Query: 147 CHSMGIMHRDVKPHNVMIDHEHRK-LRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVD 205 H I+H D+KP N+++ + R +++ID+G + + H Q + SR+++ PE+++ Sbjct: 216 LHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEH--QRVYTYIQSRFYRAPEVILG 273 Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTED------LYDYID 259 + Y +DMWSLGC+LA ++ P G D DQL + ++LG + Sbjct: 274 AR-YGMPIDMWSLGCILAELLTGY-PLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKN 331 Query: 260 KYNIELDPRFNDIL----------------GRHSRKRWERFVHSENQHLVSPEALDFLDK 303 + + PR+ + G+ R + + P LDFL + Sbjct: 332 FVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQ 391 Query: 304 LLRYDHQSRLTAREAMEHPYFY 325 L +D R+T +A+ HP+ Sbjct: 392 CLEWDPAVRMTPGQALRHPWLR 413 >4D28-A nrPDB Length = 446 Score = 245 bits (626), Expect = 2e-65, Method: Composition-based stats. Identities = 69/298 (23%), Positives = 124/298 (41%), Gaps = 52/298 (17%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKI------LKPVKKKKIKREIKILENLRGG 91 Y++ R +G G +++V A N + V +KI LK +IKREI I++ +R Sbjct: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH- 68 Query: 92 PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCH 148 PNI+ L +++ +V E V + L + + R Y +++ A+ +CH Sbjct: 69 PNIVRLYEVL--ASKSKIYIVLEFVTGGELFDRIVHKGRLKEDESRKYFQQLVDAVAHCH 126 Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEY-NVRVASRYFKGPELLVDYQ 207 S G+ HRD+KP N+++D + L++ D+GL+ G E N + + PE+L Sbjct: 127 SKGVYHRDLKPENLLLDT-NGNLKVSDFGLSALPQEGVELLNDTCGTPNYVAPEVLSGQG 185 Query: 208 MYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDP 267 + D+WS G +L ++ PF LY I+ + P Sbjct: 186 YDGSAADIWSCGVILFVILAGYLPFSETD--------------LPGLYRKINAAEFDCPP 231 Query: 268 RFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFY 325 F S E + ++L + ++R+ + + P+F Sbjct: 232 WF------------------------SAEVKFLIHRILDPNPKTRIQIQGIKKDPWFR 265 >3COM-A nrPDB Length = 314 Score = 245 bits (626), Expect = 2e-65, Method: Composition-based stats. Identities = 64/320 (20%), Positives = 124/320 (38%), Gaps = 46/320 (14%) Query: 13 TDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP 72 + R+ + + ++ + ++ KLG G Y V++AI+ + V +K + Sbjct: 5 VQLRNPPRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPV 64 Query: 73 V-KKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ----T 127 ++I +EI I++ P+++ +V E+ + + T Sbjct: 65 ESDLQEIIKEISIMQQC-DSPHVVKYYGSYFKNTD--LWIVMEYCGAGSVSDIIRLRNKT 121 Query: 128 LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQ 186 LT+ +I + LK L+Y H M +HRD+K N++++ E +L D+G+A + Sbjct: 122 LTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHA-KLADFGVAGQLTDTMA 180 Query: 187 EYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIA 246 + N + + ++ PE++ + Y+ D+WSLG M K P+ H Sbjct: 181 KRNTVIGTPFWMAPEVIQEI-GYNCVADIWSLGITAIEMAEGKPPYADIH---------- 229 Query: 247 KVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLR 306 I P F L S DF+ + L Sbjct: 230 -------PMRAIFMIPTNPPPTFR------------------KPELWSDNFTDFVKQCLV 264 Query: 307 YDHQSRLTAREAMEHPYFYT 326 + R TA + ++HP+ + Sbjct: 265 KSPEQRATATQLLQHPFVRS 284 >4L42-A nrPDB Length = 346 Score = 245 bits (625), Expect = 3e-65, Method: Composition-based stats. Identities = 80/360 (22%), Positives = 142/360 (39%), Gaps = 62/360 (17%) Query: 32 EWGNQDDYQLVRKLGRGKYSEVFEAINI---TNNEKVVVKILKP-------VKKKKIKRE 81 E + ++L+R LG+G Y +VF+ + + +K+LK K E Sbjct: 13 EKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAE 72 Query: 82 IKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMY 138 ILE ++ P I+ L + L+ E+++ + + + FY+ Sbjct: 73 RNILEEVKH-PFIVDLIYAFQ--TGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLA 129 Query: 139 EILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF-YHPGQEYNVRVASRYF 197 EI AL + H GI++RD+KP N+M++H+ ++L D+GL + H G + + + Sbjct: 130 EISMALGHLHQKGIIYRDLKPENIMLNHQGH-VKLTDFGLCKESIHDGTVTHTFCGTIEY 188 Query: 198 KGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDY 257 PE+L+ ++ ++D WSLG ++ M+ PF G + + +I Sbjct: 189 MAPEILM-RSGHNRAVDWWSLGALMYDMLTGAPPF-TGENRKKTIDKI------------ 234 Query: 258 IDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT--- 314 K + L P EA D L KLL+ + SRL Sbjct: 235 -LKCKLNLPPYLTQ------------------------EARDLLKKLLKRNAASRLGAGP 269 Query: 315 --AREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLGPLAGSPV 372 A E HP+F + ++ P S ++ S +P+ S + Sbjct: 270 GDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTL 329 >4JXF-A nrPDB Length = 266 Score = 244 bits (624), Expect = 4e-65, Method: Composition-based stats. Identities = 64/300 (21%), Positives = 132/300 (44%), Gaps = 54/300 (18%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL------KPVKKKKIKREIKILENLRG 90 +D+++ LG+G ++ V+ A +I +V +K++ K ++++ E+KI L+ Sbjct: 7 EDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKH 66 Query: 91 GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ----TLTDYDIRFYMYEILKALDY 146 P+I+ L + +D S LV E +N + + + ++ + R +M++I+ + Y Sbjct: 67 -PSILELYNYFED--SNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLY 123 Query: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH-PGQEYNVRVASRYFKGPELLVD 205 HS GI+HRD+ N+++ + +++ D+GLA P +++ + + PE + Sbjct: 124 LHSHGILHRDLTLSNLLLTR-NMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPE-IAT 181 Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIEL 265 + D+WSLGCM +++ + PF + L ++ Sbjct: 182 RSAHGLESDVWSLGCMFYTLLIGRPPF-DTDTVKNTLNKVV------------------- 221 Query: 266 DPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFY 325 E +S EA D + +LLR + RL+ ++HP+ Sbjct: 222 ------------------LADYEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFMS 263 >2I6L-A nrPDB Length = 320 Score = 244 bits (624), Expect = 4e-65, Method: Composition-based stats. Identities = 82/318 (25%), Positives = 152/318 (47%), Gaps = 31/318 (9%) Query: 29 HVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL---KPVKKKKIKREIKIL 85 ++ + Y ++ LG G VF A++ +++V +K + P K REIKI+ Sbjct: 3 NIHGFDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKHALREIKII 62 Query: 86 ENLRGGPNIITLADIVKDPVS------------RTPALVFEHVNNTDFKQLYQ--TLTDY 131 L NI+ + +I+ S + +V E++ TD + + L + Sbjct: 63 RRL-DHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYME-TDLANVLEQGPLLEE 120 Query: 132 DIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVR 191 R +MY++L+ L Y HS ++HRD+KP N+ I+ E L++ D+GLA P + Sbjct: 121 HARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGH 180 Query: 192 VA----SRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAK 247 ++ +++++ P LL+ Y ++DMW+ GC+ A M+ K F G +Q+ I + Sbjct: 181 LSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKT-LFAGAHELEQMQLILE 239 Query: 248 VLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRY 307 + +++ + + + P + K + + +S EA+DFL+++L + Sbjct: 240 SI--PVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPG-----ISREAVDFLEQILTF 292 Query: 308 DHQSRLTAREAMEHPYFY 325 RLTA EA+ HPY Sbjct: 293 SPMDRLTAEEALSHPYMS 310 >1VZO-A nrPDB Length = 355 Score = 244 bits (623), Expect = 4e-65, Method: Composition-based stats. Identities = 67/339 (19%), Positives = 141/339 (41%), Gaps = 61/339 (17%) Query: 37 DDYQLVRKLGRGKYSEVFEAINI---TNNEKVVVKILKP-------VKKKKIKREIKILE 86 ++++L++ LG G Y +VF I + +K+LK + + E ++LE Sbjct: 54 ENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLE 113 Query: 87 NLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKA 143 ++R P ++TL + L+ +++N + + T+++++ Y+ EI+ A Sbjct: 114 HIRQSPFLVTLHYAFQTET--KLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLA 171 Query: 144 LDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYN--VRVASRYFKGPE 201 L++ H +GI++RD+K N+++D + L D+GL++ + + + + P+ Sbjct: 172 LEHLHKLGIIYRDIKLENILLDSNGHVV-LTDFGLSKEFVADETERAYDFCGTIEYMAPD 230 Query: 202 LLVDY-QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDK 260 ++ +D ++D WSLG ++ ++ PF + Q ++L +E Y Sbjct: 231 IVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPY----- 285 Query: 261 YNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT-----A 315 +S A D + +LL D + RL A Sbjct: 286 -----------------------------PQEMSALAKDLIQRLLMKDPKKRLGCGPRDA 316 Query: 316 REAMEHPYFYTVVKDQA---RMGSSSMPGGSTPVSSANM 351 E EH +F + D ++ + P + +N Sbjct: 317 DEIKEHLFFQKINWDDLAAKKVPAPFKPVIRDELDVSNF 355 >3TXO-A nrPDB Length = 353 Score = 244 bits (623), Expect = 5e-65, Method: Composition-based stats. Identities = 70/343 (20%), Positives = 122/343 (35%), Gaps = 61/343 (17%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPV------KKKKIKREIKILENLRG 90 D+++ +R LG+G + +V A + VK+LK + E +IL R Sbjct: 23 DNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARN 82 Query: 91 GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYC 147 P + L + P V E VN D Q + RFY EI+ AL + Sbjct: 83 HPFLTQLFCCFQTP--DRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFL 140 Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF-YHPGQEYNVRVASRYFKGPELLVDY 206 H GI++RD+K NV++DHE +L D+G+ + G + + PE+L + Sbjct: 141 HDKGIIYRDLKLDNVLLDHEGH-CKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEM 199 Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 266 +Y ++D W++G +L M+ PF +++ +L E +Y Sbjct: 200 -LYGPAVDWWAMGVLLYEMLCGHAPFEAENED----DLFEAILNDEVVY----------- 243 Query: 267 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTA------REAME 320 + +A L + + RL + + Sbjct: 244 -----------------------PTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILR 280 Query: 321 HPYFYTVVKDQAR---MGSSSMPGGSTPVSSANMMSGISSVPT 360 HP+F + Q + P + +N Sbjct: 281 HPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEP 323 >4D2V-A nrPDB Length = 356 Score = 244 bits (623), Expect = 5e-65, Method: Composition-based stats. Identities = 71/310 (22%), Positives = 133/310 (42%), Gaps = 51/310 (16%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP----VKKKKIKREIKILENLRGGPNI 94 Y+L +G G +++V A +I E V +KI+ +IK EI+ L+NLR +I Sbjct: 31 YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNLRHQ-HI 89 Query: 95 ITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCHSMG 151 L +++ + +V E+ + L++ + R +I+ A+ Y HS G Sbjct: 90 CQLYHVLE--TANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQG 147 Query: 152 IMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYN--VRVASRYFKGPELLVDYQMY 209 HRD+KP N++ D E+ KL+LID+GL ++Y+ + + PEL+ Sbjct: 148 YAHRDLKPENLLFD-EYHKLKLIDFGLCAKPKGNKDYHLQACCGALAYAAPELIQGKSYL 206 Query: 210 DYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRF 269 D+WS+G +L ++ PF D+ +AK++ Sbjct: 207 GSEADVWSMGILLYVLMCGFLPF----DDDTAAALVAKIM-------------------- 242 Query: 270 NDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 329 G++ +W +SP ++ L ++L+ D + R++ + + HP+ Sbjct: 243 ---RGKYDVPKW-----------LSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYN 288 Query: 330 DQARMGSSSM 339 S + Sbjct: 289 YPVEWQSKNP 298 >2UV2-A nrPDB Length = 325 Score = 244 bits (622), Expect = 7e-65, Method: Composition-based stats. Identities = 72/311 (23%), Positives = 131/311 (42%), Gaps = 51/311 (16%) Query: 25 DYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKR---E 81 YE + +D ++++ +LG G + +V++A N + K++ +++++ E Sbjct: 25 QYEHVTRDLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVE 84 Query: 82 IKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNT----DFKQLYQTLTDYDIRFYM 137 I IL + PNI+ L D ++ E +L + LT+ I+ Sbjct: 85 IDILASC-DHPNIVKLLDAF--YYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVC 141 Query: 138 YEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGL-AEFYHPGQEYNVRVASRY 196 + L AL+Y H I+HRD+K N++ + ++L D+G+ A+ Q + + + Y Sbjct: 142 KQTLDALNYLHDNKIIHRDLKAGNILFTLDG-DIKLADFGVSAKNTRTIQRRDSFIGTPY 200 Query: 197 FKGPELLV----DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTE 252 + PE+++ + YDY D+WSLG L M EP H + L++IAK Sbjct: 201 WMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAE-IEPPHHELNPMRVLLKIAK----- 254 Query: 253 DLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSR 312 ++ RW S DFL K L + +R Sbjct: 255 -----------------SEPPTLAQPSRW------------SSNFKDFLKKCLEKNVDAR 285 Query: 313 LTAREAMEHPY 323 T + ++HP+ Sbjct: 286 WTTSQLLQHPF 296 >4CQG-A nrPDB Length = 331 Score = 243 bits (621), Expect = 7e-65, Method: Composition-based stats. Identities = 70/310 (22%), Positives = 133/310 (42%), Gaps = 51/310 (16%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP----VKKKKIKREIKILENLRGGPNI 94 Y+L +G G +++V A ++ E V +KI+ ++K EI L++LR +I Sbjct: 11 YELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGSDLPRVKTEIDALKSLRHQ-HI 69 Query: 95 ITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCHSMG 151 L +++ +V E+ + L++ + R +IL A+ Y HS G Sbjct: 70 CQLYHVLE--TKNKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQILSAVAYVHSQG 127 Query: 152 IMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVR--VASRYFKGPELLVDYQMY 209 HRD+KP N++ D E+ KL+LID+GL ++Y+++ S + PEL+ Sbjct: 128 YAHRDLKPENLLFD-ENHKLKLIDFGLCAKPKGNKDYHLQECCGSLAYAAPELIQGKSYL 186 Query: 210 DYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRF 269 D+WS+G +L ++ PF D+ + + K++ Sbjct: 187 GSEADVWSMGILLYVLMCGFLPF----DDDNVMALYKKIM-------------------- 222 Query: 270 NDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 329 G++ +W +SP ++ L ++L+ D + R++ R + HP+ Sbjct: 223 ---RGKYEVPKW-----------LSPSSILLLQQMLQVDPKKRISMRNLLNHPWVMQDYS 268 Query: 330 DQARMGSSSM 339 S + Sbjct: 269 CPVEWQSKTP 278 >4RLP-A nrPDB Length = 288 Score = 243 bits (620), Expect = 1e-64, Method: Composition-based stats. Identities = 75/324 (23%), Positives = 132/324 (40%), Gaps = 62/324 (19%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINI---TNNEKVVVKILKP-------VKKKKIKREIKIL 85 + ++L+R LG+G Y +VF+ + + +K+LK K E IL Sbjct: 4 PECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNIL 63 Query: 86 ENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILK 142 E ++ P I+ L + L+ E+++ + + + FY+ EI Sbjct: 64 EEVKH-PFIVDLIYAFQ--TGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISM 120 Query: 143 ALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF-YHPGQEYNVRVASRYFKGPE 201 AL + H GI++RD+KP N+M++H+ ++L D+GL + H G + + + PE Sbjct: 121 ALGHLHQKGIIYRDLKPENIMLNHQGH-VKLTDFGLCKESIHDGTVTHTFCGTIEYMAPE 179 Query: 202 LLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKY 261 +L+ ++ ++D WSLG ++ M+ PF G + + +I K Sbjct: 180 ILM-RSGHNRAVDWWSLGALMYDMLTGAPPF-TGENRKKTIDKI-------------LKC 224 Query: 262 NIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT-----AR 316 + L P EA D L KLL+ + SRL A Sbjct: 225 KLNLPPYLTQ------------------------EARDLLKKLLKRNAASRLGAGPGDAG 260 Query: 317 EAMEHPYFYTVVKDQARMGSSSMP 340 E HP+F + ++ P Sbjct: 261 EVQAHPFFRHINWEELLARKVEPP 284 >6FD3-A nrPDB Length = 300 Score = 243 bits (620), Expect = 1e-64, Method: Composition-based stats. Identities = 68/294 (23%), Positives = 127/294 (43%), Gaps = 46/294 (15%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPV---KKKKIKREIKILENLRGGPNI 94 Y K+G+G V+ A++I ++V +K + KK+ I EI ++ + PNI Sbjct: 23 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKN-PNI 81 Query: 95 ITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ--TLTDYDIRFYMYEILKALDYCHSMGI 152 + D V +V E++ + + + I E L+ALD+ HS + Sbjct: 82 VNYLDSY--LVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQV 139 Query: 153 MHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ-EYNVRVASRYFKGPELLVDYQMYDY 211 +HRD+K N+++ + ++L D+G P Q + + V + Y+ PE++ + Y Sbjct: 140 IHRDIKSDNILLGMDG-SVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVV-TRKAYGP 197 Query: 212 SLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFND 271 +D+WSLG M M+ + P+ ++N + + + GT +L Sbjct: 198 KVDIWSLGIMAIEMVEGEPPYL--NENPLRALYLIATNGTPEL----------------- 238 Query: 272 ILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFY 325 +N +S DFL++ L D R +A+E ++HP+ Sbjct: 239 ----------------QNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLK 276 >1NY3-A nrPDB Length = 400 Score = 243 bits (620), Expect = 1e-64, Method: Composition-based stats. Identities = 81/366 (22%), Positives = 143/366 (39%), Gaps = 67/366 (18%) Query: 37 DDYQLV-RKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNII 95 DDY++ + LG G +V + N EK +K+L K +RE+++ P+I+ Sbjct: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML--QDCPKARREVELHWRASQCPHIV 118 Query: 96 TLADIVKD--PVSRTPALVFEHVNNTDFKQLYQ-----TLTDYDIRFYMYEILKALDYCH 148 + D+ ++ + +V E ++ + Q T+ + M I +A+ Y H Sbjct: 119 RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 178 Query: 149 SMGIMHRDVKPHNVMIDHE--HRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDY 206 S+ I HRDVKP N++ + + L+L D+G A+ + Y+ PE+L Sbjct: 179 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVL-GP 237 Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 266 + YD S DMWSLG ++ ++ PF+ H + + + I E Sbjct: 238 EKYDKSCDMWSLGVIMYILLCGYPPFYSNH----------GLAISPGMKTRIRMGQYEFP 287 Query: 267 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYT 326 + VS E + LL+ + R+T E M HP+ Sbjct: 288 --------------------NPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI-- 325 Query: 327 VVKDQARMGSSSMPGGSTPVSSANMMSGIS------SVPTPSPLG-------PLAGSPVI 373 M S+ +P TP+ ++ ++ S L + + Sbjct: 326 -------MQSTKVP--QTPLHTSRVLKEDKERWEDVKEEMTSALATMRVDYEQIKIKKIE 376 Query: 374 AAANPL 379 A+NPL Sbjct: 377 DASNPL 382 >4CZT-A nrPDB Length = 464 Score = 242 bits (619), Expect = 2e-64, Method: Composition-based stats. Identities = 68/300 (22%), Positives = 126/300 (42%), Gaps = 54/300 (18%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK------KKIKREIKILENLRGG 91 Y+L R LG G +++V A N+ N + V +K++ K +IKREI ++ ++ Sbjct: 12 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH- 70 Query: 92 PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYCH 148 PN+I + +++ V E V + + L + + R Y +++ A+DYCH Sbjct: 71 PNVIRMFEVMASKT--KIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCH 128 Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA---EFYHPGQEYNVRVASRYFKGPELLVD 205 S G+ HRD+KP N+++D + L++ D+GL+ + + + + PE++ + Sbjct: 129 SRGVYHRDLKPENLLLDA-NGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINN 187 Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIEL 265 D+WS G +L ++ PF + LY I K Sbjct: 188 KGYDGAKADLWSCGVILFVLMAGYLPFEDSN--------------LTSLYKKIFKAEFTC 233 Query: 266 DPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFY 325 P F S A + ++L + +R+T E +E+ +F Sbjct: 234 PPWF------------------------SASAKKLIKRILDPNPATRITFAEVIENEWFK 269 >5D7A-A nrPDB Length = 308 Score = 242 bits (618), Expect = 2e-64, Method: Composition-based stats. Identities = 69/309 (22%), Positives = 128/309 (41%), Gaps = 53/309 (17%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPV--KKKKIKREIKILENLRGGPNIIT 96 ++LV +G G Y +V++ ++ + +K++ ++++IK+EI +L+ NI T Sbjct: 19 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIAT 78 Query: 97 LADIV--KDP--VSRTPALVFEHVNNTDFKQLYQ-----TLTDYDIRFYMYEILKALDYC 147 K+P + LV E L + TL + I + EIL+ L + Sbjct: 79 YYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHL 138 Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGL-AEFYHPGQEYNVRVASRYFKGPELLVDY 206 H ++HRD+K NV++ E+ +++L+D+G+ A+ N + + Y+ PE++ Sbjct: 139 HQHKVIHRDIKGQNVLLT-ENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACD 197 Query: 207 QM----YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYN 262 + YD+ D+WSLG M P L D Sbjct: 198 ENPDATYDFKSDLWSLGITAIEMAEGAPP----------------------LCDMHPMRA 235 Query: 263 IELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHP 322 + L PR + R K+W S + F++ L +H R + M+HP Sbjct: 236 LFLIPR--NPAPRLKSKKW------------SKKFQSFIESCLVKNHSQRPATEQLMKHP 281 Query: 323 YFYTVVKDQ 331 + ++ Sbjct: 282 FIRDQPNER 290 >2OZA-A nrPDB Length = 356 Score = 242 bits (617), Expect = 2e-64, Method: Composition-based stats. Identities = 81/366 (22%), Positives = 143/366 (39%), Gaps = 67/366 (18%) Query: 37 DDYQLV-RKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNII 95 DDY++ + LG G +V + N EK +K+L K +RE+++ P+I+ Sbjct: 17 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML--QDCPKARREVELHWRASQCPHIV 74 Query: 96 TLADIVKD--PVSRTPALVFEHVNNTDFKQLYQ-----TLTDYDIRFYMYEILKALDYCH 148 + D+ ++ + +V E ++ + Q T+ + M I +A+ Y H Sbjct: 75 RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 134 Query: 149 SMGIMHRDVKPHNVMIDHE--HRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDY 206 S+ I HRDVKP N++ + + L+L D+G A+ + Y+ PE+L Sbjct: 135 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVL-GP 193 Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 266 + YD S DMWSLG ++ ++ PF+ H + + + I E Sbjct: 194 EKYDKSCDMWSLGVIMYILLCGYPPFYSNH----------GLAISPGMKTRIRMGQYEFP 243 Query: 267 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYT 326 + VS E + LL+ + R+T E M HP+ Sbjct: 244 --------------------NPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI-- 281 Query: 327 VVKDQARMGSSSMPGGSTPVSSANMMSGIS------SVPTPSPLG-------PLAGSPVI 373 M S+ +P TP+ ++ ++ S L + + Sbjct: 282 -------MQSTKVP--QTPLHTSRVLKEDKERWEDVKEEMTSALATMRVDYEQIKIKKIE 332 Query: 374 AAANPL 379 A+NPL Sbjct: 333 DASNPL 338 >3KA0-A nrPDB Length = 320 Score = 241 bits (616), Expect = 3e-64, Method: Composition-based stats. Identities = 75/328 (22%), Positives = 134/328 (40%), Gaps = 54/328 (16%) Query: 37 DDYQLV-RKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNII 95 DDY++ + LG G +V + N EK +K+L K +RE+++ P+I+ Sbjct: 15 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML--QDCPKARREVELHWRASQCPHIV 72 Query: 96 TLADIVKD--PVSRTPALVFEHVNNTDFKQLYQ-----TLTDYDIRFYMYEILKALDYCH 148 + D+ ++ + +V E ++ + Q T+ + M I +A+ Y H Sbjct: 73 RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 132 Query: 149 SMGIMHRDVKPHNVMIDHE--HRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDY 206 S+ I HRDVKP N++ + + L+L D+G A+ + Y+ PE+L Sbjct: 133 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTEPCYTPYYVAPEVL-GP 191 Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 266 + YD S DMWSLG ++ ++ PF+ H + + + I E Sbjct: 192 EKYDKSCDMWSLGVIMYILLCGYPPFYSNH----------GLAISPGMKTRIRMGQYEFP 241 Query: 267 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYT 326 + VS E + LL+ + R+T E M HP+ Sbjct: 242 --------------------NPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI-- 279 Query: 327 VVKDQARMGSSSMPGGSTPVSSANMMSG 354 M S+ +P TP+ ++ ++ Sbjct: 280 -------MQSTKVP--QTPLHTSRVLKE 298 >6CKI-A nrPDB Length = 316 Score = 241 bits (615), Expect = 4e-64, Method: Composition-based stats. Identities = 72/322 (22%), Positives = 134/322 (41%), Gaps = 42/322 (13%) Query: 36 QDDYQLVR-KLGRGKYSEVFEAINITNNEKVVVKILKPVK---KKKIKREIKILENLRGG 91 +D YQL LG G ++ V IN+ +++ VKI++ + ++ RE+++L +G Sbjct: 11 EDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQCQGH 70 Query: 92 PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYCH 148 N++ I LVFE + + + + ++ ALD+ H Sbjct: 71 RNVL--ELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLH 128 Query: 149 SMGIMHRDVKPHNVMIDHEHRK--LRLIDWGLAEFYH--------PGQEYNVRVASRYFK 198 + GI HRD+KP N++ +H ++ +++ D+GL E S + Sbjct: 129 NKGIAHRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPELLTPCGSAEYM 188 Query: 199 GPELL----VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDL 254 PE++ + +YD D+WSLG +L ++ PF G++ Sbjct: 189 APEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPF-------------VGRCGSDCG 235 Query: 255 YDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT 314 +D E P ++L ++ F + H +S A D + KLL D + RL+ Sbjct: 236 WD-----RGEACPACQNMLFESIQEGKYEFPDKDWAH-ISCAAKDLISKLLVRDAKQRLS 289 Query: 315 AREAMEHPYFYTVVKDQARMGS 336 A + ++HP+ + Sbjct: 290 AAQVLQHPWVQGCAPENTLPTP 311 >5N23-A nrPDB Length = 352 Score = 241 bits (615), Expect = 4e-64, Method: Composition-based stats. Identities = 71/345 (20%), Positives = 135/345 (39%), Gaps = 61/345 (17%) Query: 25 DYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKR---- 80 +ES + D ++ +R LG G + V + +KIL K K+K+ Sbjct: 30 KWESPAQNTAHLDQFERIRTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHT 89 Query: 81 --EIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRF 135 E +I + P ++ L KD + +V E+ + + ++ RF Sbjct: 90 LNEKRI-QQAVNFPFLVKLEFSFKD--NSNLYMVLEYAPGGEMFSHLRRIGRFSEPHARF 146 Query: 136 YMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASR 195 Y +I+ +Y HS+ +++RD+KP N++ID + +++ D+G A+ G+ + Sbjct: 147 YAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY-IKVADFGFAKRVK-GRTPWTLCGTP 204 Query: 196 YFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLY 255 + PE+++ + Y+ ++D W+LG ++ M PFF DQ ++I Y Sbjct: 205 EYLAPEIILS-KGYNKAVDWWALGVLIYEMAAGYPPFF-----ADQPIQI---------Y 249 Query: 256 DYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRL-- 313 + I + F S + D L LL+ D R Sbjct: 250 EKIVSGKVRFPSHF------------------------SSDLKDLLRNLLQVDLTKRFGN 285 Query: 314 ---TAREAMEHPYFYTVVK---DQARMGSSSMPGGSTPVSSANMM 352 + H +F T Q ++ + +P P ++N Sbjct: 286 LKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFD 330 >4RA4-A nrPDB Length = 355 Score = 241 bits (614), Expect = 6e-64, Method: Composition-based stats. Identities = 75/366 (20%), Positives = 123/366 (33%), Gaps = 63/366 (17%) Query: 20 PREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPV------ 73 P E S+ ++ D+ + LG+G + +V A E +KILK Sbjct: 3 PSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDD 62 Query: 74 KKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ---TLTD 130 + E ++L L P + L + V E+VN D Q + Sbjct: 63 DVECTMVEKRVLALLDKPPFLTQLHSCFQ--TVDRLYFVMEYVNGGDLMYHIQQVGKFKE 120 Query: 131 YDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF-YHPGQEYN 189 FY EI L + H GI++RD+K NVM+D E +++ D+G+ + G Sbjct: 121 PQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGH-IKIADFGMCKEHMMDGVTTR 179 Query: 190 VRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVL 249 + + PE++ YQ Y S+D W+ G +L M+ + PF G D + I + Sbjct: 180 TFCGTPDYIAPEIIA-YQPYGKSVDWWAYGVLLYEMLAGQPPF-DGEDEDELFQSIME-- 235 Query: 250 GTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDH 309 + +S EA+ L+ Sbjct: 236 -----------------------------------HNVSYPKSLSKEAVSICKGLMTKHP 260 Query: 310 QSRLTA-----REAMEHPYFYTVVKDQARMGSSSMP------GGSTPVSSANMMSGISSV 358 RL R+ EH +F + ++ P G G + Sbjct: 261 AKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVSGKGAENFDKFFTRGQPVL 320 Query: 359 PTPSPL 364 P L Sbjct: 321 TPPDQL 326 >3A8W-A nrPDB Length = 345 Score = 240 bits (612), Expect = 1e-63, Method: Composition-based stats. Identities = 83/345 (24%), Positives = 136/345 (39%), Gaps = 56/345 (16%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPV------KKKKIKREIKILENLRG 90 D+ L+R +GRG Y++V + +K++K ++ E + E Sbjct: 9 QDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASN 68 Query: 91 GPNIITLADIVKDPVSRTPALVFEHVNNTDFK---QLYQTLTDYDIRFYMYEILKALDYC 147 P ++ L + V E+VN D Q + L + RFY EI AL+Y Sbjct: 69 HPFLVGLHSCFQ--TESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYL 126 Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF-YHPGQEYNVRVASRYFKGPELLVDY 206 H GI++RD+K NV++D E ++L D+G+ + PG + + + PE+L Sbjct: 127 HERGIIYRDLKLDNVLLDSEGH-IKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRG- 184 Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFF--HGHDNYDQLVRIAKVLGTEDLYDYIDKYNIE 264 + Y +S+D W+LG ++ M+ + PF DN DQ + DY+ + +E Sbjct: 185 EDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQ-----------NTEDYLFQVILE 233 Query: 265 LDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTA------REA 318 R L S +A L L D + RL + Sbjct: 234 KQIRIPRSL--------------------SVKAASVLKSFLNKDPKERLGCHPQTGFADI 273 Query: 319 MEHPYFYTVVKD---QARMGSSSMPGGSTPVSSANMMSGISSVPT 360 HP+F V D Q ++ P S N S ++ P Sbjct: 274 QGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPV 318 >6CMJ-A nrPDB Length = 321 Score = 239 bits (611), Expect = 1e-63, Method: Composition-based stats. Identities = 69/327 (21%), Positives = 137/327 (41%), Gaps = 63/327 (19%) Query: 22 EYWDYESHVVEWGNQ------DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK 75 E ++ H V D Y L ++G+G Y V A N +N +K+L K Sbjct: 13 ENLYFQGHHVSITGMQDCVQLDQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKL 72 Query: 76 --------------KKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDF 121 +++ +EI IL+ L PN++ L +++ DP +VFE VN Sbjct: 73 IRQAGGCIQPRGPIEQVYQEIAILKKL-DHPNVVKLVEVLDDPNEDHLYMVFELVNQGPV 131 Query: 122 KQL--YQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA 179 ++ + L++ RFY +++K ++Y H I+HRD+KP N+++ + +++ D+G++ Sbjct: 132 MEVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGH-IKIADFGVS 190 Query: 180 EFYH-PGQEYNVRVASRYFKGPELLVDYQMY--DYSLDMWSLGCMLASMIFRKEPFFHGH 236 + + V + F PE L + + +LD+W++G L +F + PF Sbjct: 191 NEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMD-- 248 Query: 237 DNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPE 296 +++ K + + +Q ++ + Sbjct: 249 ---------ERIMC-------------------------LHSKIKSQALEFPDQPDIAED 274 Query: 297 ALDFLDKLLRYDHQSRLTAREAMEHPY 323 D + ++L + +SR+ E HP+ Sbjct: 275 LKDLITRMLDKNPESRIVVPEIKLHPW 301 >5X8I-B nrPDB Length = 346 Score = 239 bits (611), Expect = 1e-63, Method: Composition-based stats. Identities = 75/333 (22%), Positives = 146/333 (43%), Gaps = 43/333 (12%) Query: 38 DYQLVRKLGRGKYSEVFEAI-NITNNEKVVVKILKPVKK--KKIKREIKILENLRG-GPN 93 Y++V LG G + +V E I + V VKI+K V + + + EI++LE+L PN Sbjct: 14 RYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPN 73 Query: 94 ----IITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ----TLTDYDIRFYMYEILKALD 145 + + + + +VFE + + + + + IR Y+I K+++ Sbjct: 74 STFRCVQMLEWFEH--HGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVN 131 Query: 146 YCHSMGIMHRDVKPHNVMIDHE------------------HRKLRLIDWGLAEFYHPGQE 187 + HS + H D+KP N++ + ++++D+G A + + Sbjct: 132 FLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATY--DDEH 189 Query: 188 YNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAK 247 ++ V++R+++ PE+++ + D+WS+GC+L F HD+ + L + + Sbjct: 190 HSTLVSTRHYRAPEVILAL-GWSQPCDVWSIGCILIEYYLGFTVF-PTHDSKEHLAMMER 247 Query: 248 VLGTEDLYDYIDKYNIE------LDPRFNDILGRHSRKRWERFVHSENQHLVSPE-ALDF 300 +LG + + LD + GR+ + + V E D Sbjct: 248 ILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQDVEHERLFDL 307 Query: 301 LDKLLRYDHQSRLTAREAMEHPYFYTVVKDQAR 333 + K+L YD R+T REA++HP+F + K Sbjct: 308 IQKMLEYDPAKRITLREALKHPFFDLLKKSILE 340 >4WB7-A nrPDB Length = 405 Score = 239 bits (610), Expect = 1e-63, Method: Composition-based stats. Identities = 71/345 (20%), Positives = 136/345 (39%), Gaps = 62/345 (17%) Query: 25 DYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKR---- 80 +ES + D ++ ++ LG G + V + +KIL K K+K+ Sbjct: 84 KWESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHT 143 Query: 81 --EIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRF 135 E +IL+ + P ++ L KD + +V E+V + + ++ RF Sbjct: 144 LNEKRILQAV-NFPFLVKLEFSFKD--NSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARF 200 Query: 136 YMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASR 195 Y +I+ +Y HS+ +++RD+KP N++ID + +++ D+G A+ + Sbjct: 201 YAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY-IQVTDFGFAKRVK--GRTWTLCGTP 257 Query: 196 YFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLY 255 + PE+++ + Y+ ++D W+LG ++ M PFF DQ ++I Y Sbjct: 258 EYLAPEIILS-KGYNKAVDWWALGVLIYEMAAGYPPFF-----ADQPIQI---------Y 302 Query: 256 DYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRL-- 313 + I + F S + D L LL+ D R Sbjct: 303 EKIVSGKVRFPSHF------------------------SSDLKDLLRNLLQVDLTKRFGN 338 Query: 314 ---TAREAMEHPYFYTVVK---DQARMGSSSMPGGSTPVSSANMM 352 + H +F T Q ++ + +P P ++N Sbjct: 339 LKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFD 383 >2Z7Q-A nrPDB Length = 321 Score = 239 bits (610), Expect = 2e-63, Method: Composition-based stats. Identities = 68/342 (19%), Positives = 135/342 (39%), Gaps = 63/342 (18%) Query: 32 EWGNQDDYQLVRKLGRGKYSEVFEAINI---TNNEKVVVKILKPV-----KKKKIKREIK 83 E + ++L++ LG+G + +VF + + +K+LK + + K E Sbjct: 23 EKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERD 82 Query: 84 ILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEI 140 IL ++ P ++ L + L+ + + D T+ D++FY+ E+ Sbjct: 83 ILADV-NHPFVVKLHYAFQ--TEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAEL 139 Query: 141 LKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF-YHPGQEYNVRVASRYFKG 199 LD+ HS+GI++RD+KP N+++D E ++L D+GL++ ++ + + Sbjct: 140 ALGLDHLHSLGIIYRDLKPENILLDEEGH-IKLTDFGLSKEAIDHEKKAYSFCGTVEYMA 198 Query: 200 PELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYID 259 PE++ + Q + +S D WS G ++ M+ PF G D + + I K Sbjct: 199 PEVV-NRQGHSHSADWWSYGVLMFEMLTGSLPF-QGKDRKETMTLILK------------ 244 Query: 260 KYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRL-----T 314 +S EA L L + + +RL Sbjct: 245 -------------------------AKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDG 279 Query: 315 AREAMEHPYFYTVVKDQA---RMGSSSMPGGSTPVSSANMMS 353 A E H ++ T+ ++ + P + P + + Sbjct: 280 AEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDT 321 >5X3F-B nrPDB Length = 393 Score = 239 bits (609), Expect = 2e-63, Method: Composition-based stats. Identities = 70/345 (20%), Positives = 135/345 (39%), Gaps = 62/345 (17%) Query: 25 DYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKR---- 80 +E+ D + ++ LG G + V + + +KIL K K+K+ Sbjct: 72 KWETPSQNTAQLDQFDRIKTLGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQIEHT 131 Query: 81 --EIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRF 135 E +IL+ + P ++ L KD + +V E+V + + ++ RF Sbjct: 132 LNEKRILQAV-NFPFLVKLEFSFKD--NSNLYMVMEYVAGGEMFSHLRRIGRFSEPHARF 188 Query: 136 YMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASR 195 Y +I+ +Y HS+ +++RD+KP N++ID + +++ D+G A+ + Sbjct: 189 YAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY-IQVTDFGFAKRVK--GRTWTLCGTP 245 Query: 196 YFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLY 255 + PE+++ + Y+ ++D W+LG ++ M PFF DQ ++I Y Sbjct: 246 EYLAPEIILS-KGYNKAVDWWALGVLIYEMAAGYPPFF-----ADQPIQI---------Y 290 Query: 256 DYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRL-- 313 + I + F S + D L LL+ D R Sbjct: 291 EKIVSGKVRFPSHF------------------------SSDLKDLLRNLLQVDLTKRFGN 326 Query: 314 ---TAREAMEHPYFYTVVK---DQARMGSSSMPGGSTPVSSANMM 352 + H +F T Q ++ + +P P ++N Sbjct: 327 LKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFD 371 >3FXW-A nrPDB Length = 336 Score = 239 bits (609), Expect = 2e-63, Method: Composition-based stats. Identities = 71/305 (23%), Positives = 121/305 (39%), Gaps = 44/305 (14%) Query: 32 EWGNQDDYQLVR-KLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRG 90 ++ DDYQL + LG G +V E + +K +K+L K ++E+ G Sbjct: 23 KYAVTDDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLL--YDSPKARQEVDHHWQASG 80 Query: 91 GPNIITLADIVKD--PVSRTPALVFEHVNNTDFKQLYQ-----TLTDYDIRFYMYEILKA 143 GP+I+ + D+ ++ R ++ E + + Q T+ + M +I A Sbjct: 81 GPHIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTA 140 Query: 144 LDYCHSMGIMHRDVKPHNVMIDHEHRK--LRLIDWGLAEFYHPGQEYNVRVASRYFKGPE 201 + + HS I HRDVKP N++ + + L+L D+G A+ + Y+ PE Sbjct: 141 IQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKET-TQNALQTPCYTPYYVAPE 199 Query: 202 LLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKY 261 +L + YD S DMWSLG ++ ++ PF+ + Sbjct: 200 VL-GPEKYDKSCDMWSLGVIMYILLCGFPPFYS---------------------NTGQAI 237 Query: 262 NIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEH 321 + + R W VS +A + LL+ D RLT + M H Sbjct: 238 SPGMKRRIRLGQYGFPNPEWSE---------VSEDAKQLIRLLLKTDPTERLTITQFMNH 288 Query: 322 PYFYT 326 P+ Sbjct: 289 PWINQ 293 >6FDY-U nrPDB Length = 276 Score = 238 bits (608), Expect = 3e-63, Method: Composition-based stats. Identities = 76/303 (25%), Positives = 124/303 (40%), Gaps = 51/303 (16%) Query: 33 WGNQ--DDYQLVRKLGRGKYSEVFEAI-NITNNEKVVVKI-----LKPVKKKKIKREIKI 84 WG D + L +LG G Y+ V++A E V +K L + + EI+I Sbjct: 5 WGPPRLDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEI 64 Query: 85 LENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEIL 141 L+ +R P+I+ L D D S L+ E D + T L + R +M ++ Sbjct: 65 LKGIRH-PHIVQLKDFQWD--SDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLA 121 Query: 142 KALDYCHSMGIMHRDVKPHNVMIDH-EHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGP 200 AL + H I H D+KP N+++ E L+L D+G A+ P E +V S + P Sbjct: 122 SALQFLHERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAP 181 Query: 201 ELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDK 260 E++ Q YD +D+WS+G +L +F + PF Sbjct: 182 EMVCQRQ-YDARVDLWSMGVILYEALFGQPPFAS-------------------------- 214 Query: 261 YNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAME 320 + R R + + L+S + D L +LL D R++ ++ Sbjct: 215 ---------RSFSELEEKIRSNRVIELPLRPLLSRDCRDLLQRLLERDPSRRISFQDFFA 265 Query: 321 HPY 323 HP+ Sbjct: 266 HPW 268 >4LG4-A nrPDB Length = 299 Score = 236 bits (603), Expect = 9e-63, Method: Composition-based stats. Identities = 63/302 (20%), Positives = 120/302 (39%), Gaps = 46/302 (15%) Query: 31 VEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPV-KKKKIKREIKILENLR 89 + ++ + ++ KLG G Y VF+AI+ + + V +K + ++I +EI I++ Sbjct: 5 LTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQC- 63 Query: 90 GGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ----TLTDYDIRFYMYEILKALD 145 P ++ +V E+ + + TL + +I + LK L+ Sbjct: 64 DSPYVVKYYGSYFKNTD--LWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLE 121 Query: 146 YCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLV 204 Y H M +HR++K N++++ E +L D+G+A + + N + + ++ PE++ Sbjct: 122 YLHFMRKIHRNIKAGNILLNTEGHA-KLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQ 180 Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIE 264 + Y+ D+WSLG M K P+ H I Sbjct: 181 EI-GYNCVADIWSLGITSIEMAEGKPPYADIH-----------------PMRAIFMIPTN 222 Query: 265 LDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 P F L S + DF+ K L + + R TA + ++HP+ Sbjct: 223 PPPTFR------------------KPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFI 264 Query: 325 YT 326 Sbjct: 265 KN 266 >3DAK-A nrPDB Length = 290 Score = 236 bits (603), Expect = 1e-62, Method: Composition-based stats. Identities = 59/312 (18%), Positives = 117/312 (37%), Gaps = 53/312 (16%) Query: 35 NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK----KIKREIKILENLRG 90 N+DDY+L +G G + V A EKV +K + K + ++ +EI+ + Sbjct: 8 NRDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQC-H 66 Query: 91 GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ-----------TLTDYDIRFYMYE 139 PNI++ V LV + ++ + + L + I + E Sbjct: 67 HPNIVSYYTSF--VVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILRE 124 Query: 140 ILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPG------QEYNVRVA 193 +L+ L+Y H G +HRDVK N+++ + +++ D+G++ F G + V Sbjct: 125 VLEGLEYLHKNGQIHRDVKAGNILLGEDG-SVQIADFGVSAFLATGGDITRNKVRKTFVG 183 Query: 194 SRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTED 253 + + PE++ + YD+ D+WS G + P+ Sbjct: 184 TPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYH----------------KYPP 227 Query: 254 LYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRL 313 + + + + + K++ + + L+ D + R Sbjct: 228 MKVLMLTLQNDPPSLETGVQDKEMLKKYGK------------SFRKMISLCLQKDPEKRP 275 Query: 314 TAREAMEHPYFY 325 TA E + H +F Sbjct: 276 TAAELLRHKFFQ 287 >6HXF-B nrPDB Length = 302 Score = 236 bits (602), Expect = 1e-62, Method: Composition-based stats. Identities = 75/320 (23%), Positives = 142/320 (44%), Gaps = 51/320 (15%) Query: 25 DYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKR---E 81 +YE + + +++V +LG G + +V++A N K+++ +++++ E Sbjct: 7 EYEHVRRDLDPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVE 66 Query: 82 IKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNT----DFKQLYQTLTDYDIRFYM 137 I+IL P I+ L ++ E +L + LT+ I+ Sbjct: 67 IEILATC-DHPYIVKLLGAYYH--DGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVC 123 Query: 138 YEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGL-AEFYHPGQEYNVRVASRY 196 ++L+AL++ HS I+HRD+K NV++ E +RL D+G+ A+ Q+ + + + Y Sbjct: 124 RQMLEALNFLHSKRIIHRDLKAGNVLMTLEG-DIRLADFGVSAKNLKTLQKRDSFIGTPY 182 Query: 197 FKGPELL----VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTE 252 + PE++ + YDY D+WSLG L M + EP H + L++IAK Sbjct: 183 WMAPEVVMCETMKDTPYDYKADIWSLGITLIEMA-QIEPPHHELNPMRVLLKIAK----- 236 Query: 253 DLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSR 312 +D + +W S E DFL L + ++R Sbjct: 237 -----------------SDPPTLLTPSKW------------SVEFRDFLKIALDKNPETR 267 Query: 313 LTAREAMEHPYFYTVVKDQA 332 +A + +EHP+ ++ ++A Sbjct: 268 PSAAQLLEHPFVSSITSNKA 287 >4AW2-A nrPDB Length = 437 Score = 235 bits (600), Expect = 2e-62, Method: Composition-based stats. Identities = 76/352 (21%), Positives = 137/352 (38%), Gaps = 58/352 (16%) Query: 35 NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL------KPVKKKKIKREIKILENL 88 +++D+++++ +GRG + EV ++ +KIL K + + E +L N Sbjct: 72 HREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVN- 130 Query: 89 RGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----LTDYDIRFYMYEILKAL 144 I TL +D LV ++ D L L + RFY+ E++ A+ Sbjct: 131 GDSKWITTLHYAFQD--DNNLYLVMDYYVGGDLLTLLSKFEDRLPEEMARFYLAEMVIAI 188 Query: 145 DYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQ-EYNVRVASRYFKGPEL 202 D H + +HRD+KP N+++D + +RL D+G + G + +V V + + PE+ Sbjct: 189 DSVHQLHYVHRDIKPDNILMDM-NGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEI 247 Query: 203 LV----DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYI 258 L Y D WSLG + M++ + PF+ + +I Sbjct: 248 LQAMEGGKGRYGPECDWWSLGVCMYEMLYGETPFY-AESLVETYGKIMN----------- 295 Query: 259 DKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRL---TA 315 ERF VS A D + +L+ + RL Sbjct: 296 ---------------------HKERFQFPTQVTDVSENAKDLIRRLIC-SREHRLGQNGI 333 Query: 316 REAMEHPYFYTVVKDQARMG-SSSMPGGSTPVSSANMMSGISSVPTPSPLGP 366 + +HP+F + D R + +P S+P ++N + + P Sbjct: 334 EDFKKHPFFSGIDWDNIRNCEAPYIPEVSSPTDTSNFDVDDDCLKNSETMPP 385 >3TKU-A nrPDB Length = 433 Score = 235 bits (600), Expect = 2e-62, Method: Composition-based stats. Identities = 75/352 (21%), Positives = 135/352 (38%), Gaps = 58/352 (16%) Query: 35 NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL------KPVKKKKIKREIKILENL 88 +++D+++++ +GRG + EV +KIL K + + E +L N Sbjct: 88 HREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVN- 146 Query: 89 RGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----LTDYDIRFYMYEILKAL 144 I L +D LV ++ D L L + RFY+ E++ A+ Sbjct: 147 GDCQWITALHYAFQD--ENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAI 204 Query: 145 DYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ--EYNVRVASRYFKGPEL 202 D H + +HRD+KP NV++D + +RL D+G + + +V V + + PE+ Sbjct: 205 DSIHQLHYVHRDIKPDNVLLDV-NGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEI 263 Query: 203 LV----DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYI 258 L Y D WSLG + M++ + PF+ + +I Sbjct: 264 LQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFY-AESLVETYGKIMNHE--------- 313 Query: 259 DKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRL---TA 315 ERF + VS EA D + +L+ + RL Sbjct: 314 -----------------------ERFQFPSHVTDVSEEAKDLIQRLIC-SRERRLGQNGI 349 Query: 316 REAMEHPYFYTVVKDQAR-MGSSSMPGGSTPVSSANMMSGISSVPTPSPLGP 366 + +H +F + + R + + +P S+P ++N + L P Sbjct: 350 EDFKKHAFFEGLNWENIRNLEAPYIPDVSSPSDTSNFDVDDDVLRNTEILPP 401 >6FYV-A nrPDB Length = 337 Score = 235 bits (599), Expect = 3e-62, Method: Composition-based stats. Identities = 72/331 (21%), Positives = 150/331 (45%), Gaps = 43/331 (12%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINIT-NNEKVVVKILKPV--KKKKIKREIKILENLRG-G 91 + Y++V LG G + +V E I+ + V VKI+K V ++ + EI++LE+L Sbjct: 13 RARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTD 72 Query: 92 PN----IITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ----TLTDYDIRFYMYEILKA 143 PN + + + +VFE + + + + + IR Y+I ++ Sbjct: 73 PNSVFRCVQMLEWFDH--HGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQS 130 Query: 144 LDYCHSMGIMHRDVKPHNVMI------------------DHEHRKLRLIDWGLAEFYHPG 185 +++ H + H D+KP N++ ++ ++++D+G A + Sbjct: 131 INFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATY--DD 188 Query: 186 QEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRI 245 + ++ V++R+++ PE+++ + D+WS+GC+L F HD+ + L + Sbjct: 189 EHHSTLVSTRHYRAPEVILAL-GWSQPCDVWSIGCILIEYYLGFTVF-QTHDSKEHLAMM 246 Query: 246 AKVLGTEDLYDYIDK------YNIELDPRFNDILGRHSRKRWERFVHSENQH-LVSPEAL 298 ++LG + ++ +LD + GR+ R+R + H + Sbjct: 247 ERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLF 306 Query: 299 DFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 329 D + ++L YD R+T EA++HP+F + K Sbjct: 307 DLVRRMLEYDPTQRITLDEALQHPFFDLLKK 337 >3ORZ-A nrPDB Length = 316 Score = 235 bits (599), Expect = 3e-62, Method: Composition-based stats. Identities = 72/319 (22%), Positives = 128/319 (40%), Gaps = 61/319 (19%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKI------LKPVKKKKIKREIKILENLRG 90 +D++ + LG G +S V A + + + +KI +K K + RE ++ L Sbjct: 37 EDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRL-D 95 Query: 91 GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYC 147 P + L +D + N + + + + RFY EI+ AL+Y Sbjct: 96 HPFFVKLYFCFQD--DEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYL 153 Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE---YNVRVASRYFKGPELLV 204 H GI+HRD+KP N++++ E +++ D+G A+ P + N V + + PELL Sbjct: 154 HGKGIIHRDLKPENILLN-EDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLT 212 Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIE 264 + S D+W+LGC++ ++ PF G++ ++ I K + Sbjct: 213 EKSAC-KSSDLWALGCIIYQLVAGLPPFRAGNEYL--------------IFQKIIKLEYD 257 Query: 265 LDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTARE------A 318 +F P+A D ++KLL D RL E Sbjct: 258 FPEKF------------------------FPKARDLVEKLLVLDATKRLGCEEMEGYGPL 293 Query: 319 MEHPYFYTVVKDQARMGSS 337 HP+F +V + + Sbjct: 294 KAHPFFESVTWENLHQQTP 312 >6AO5-A nrPDB Length = 362 Score = 235 bits (599), Expect = 3e-62, Method: Composition-based stats. Identities = 63/302 (20%), Positives = 120/302 (39%), Gaps = 46/302 (15%) Query: 31 VEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPV-KKKKIKREIKILENLR 89 + ++ + ++ KLG G Y VF+AI+ + + V +K + ++I +EI I++ Sbjct: 4 LTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQC- 62 Query: 90 GGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ----TLTDYDIRFYMYEILKALD 145 P ++ +V E+ + + TL + +I + LK L+ Sbjct: 63 DSPYVVKYYGSYFKNTD--LWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLE 120 Query: 146 YCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLV 204 Y H M +HR++K N++++ E +L D+G+A + + N + + ++ PE++ Sbjct: 121 YLHFMRKIHRNIKAGNILLNTEGHA-KLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQ 179 Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIE 264 + Y+ D+WSLG M K P+ H I Sbjct: 180 EI-GYNCVADIWSLGITSIEMAEGKPPYADIH-----------------PMRAIFMIPTN 221 Query: 265 LDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 P F L S + DF+ K L + + R TA + ++HP+ Sbjct: 222 PPPTFR------------------KPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFI 263 Query: 325 YT 326 Sbjct: 264 KN 265 >3LM0-A nrPDB Length = 327 Score = 233 bits (594), Expect = 1e-61, Method: Composition-based stats. Identities = 66/350 (18%), Positives = 140/350 (40%), Gaps = 54/350 (15%) Query: 25 DYESHVVEWGNQDDYQLV-----RKLGRGKYSEVFEAINITNNEKVVVKILKPVKK---- 75 D + + + + +++ ++LGRGK++ V + I+ + ++ K LK ++ Sbjct: 12 DLGTENLYFQSMENFNNFYILTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDC 71 Query: 76 -KKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTD-----FKQLYQTLT 129 +I EI +LE + P +I L ++ ++ L+ E+ + +L + ++ Sbjct: 72 RAEILHEIAVLELAKSCPRVINLHEVYENTSE--IILILEYAAGGEIFSLCLPELAEMVS 129 Query: 130 DYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDH--EHRKLRLIDWGLAEFYHPGQE 187 + D+ + +IL+ + Y H I+H D+KP N+++ ++++D+G++ E Sbjct: 130 ENDVIRLIKQILEGVYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACE 189 Query: 188 YNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAK 247 + + + PE+L +Y + DMW++G + ++ PF G DN + + I++ Sbjct: 190 LREIMGTPEYLAPEIL-NYDPITTATDMWNIGIIAYMLLTHTSPFV-GEDNQETYLNISQ 247 Query: 248 VLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRY 307 V E VS A DF+ LL Sbjct: 248 V---------------------------------NVDYSEETFSSVSQLATDFIQSLLVK 274 Query: 308 DHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISS 357 + + R TA + H + + + T S +S Sbjct: 275 NPEKRPTAEICLSHSWLQQWDFENLFHPEETSSSSQTQDHSVRSSEDKTS 324 >5YV8-A nrPDB Length = 298 Score = 232 bits (593), Expect = 1e-61, Method: Composition-based stats. Identities = 65/321 (20%), Positives = 132/321 (41%), Gaps = 72/321 (22%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK--------------------- 75 + Y L ++G+G Y V A N +N +K+L K Sbjct: 13 NQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGG 72 Query: 76 --------KKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQL--Y 125 +++ +EI IL+ L PN++ L +++ DP +VFE VN ++ Sbjct: 73 CIQPRGPIEQVYQEIAILKKL-DHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTL 131 Query: 126 QTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH-P 184 + L++ RFY +++K ++Y H I+HRD+KP N+++ + +++ D+G++ + Sbjct: 132 KPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGH-IKIADFGVSNEFKGS 190 Query: 185 GQEYNVRVASRYFKGPELLVDYQMY--DYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQL 242 + V + F PE L + + +LD+W++G L +F + PF Sbjct: 191 DALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMD-------- 242 Query: 243 VRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLD 302 +++ K + + +Q ++ + D + Sbjct: 243 ---ERIMC-------------------------LHSKIKSQALEFPDQPDIAEDLKDLIT 274 Query: 303 KLLRYDHQSRLTAREAMEHPY 323 ++L + +SR+ E HP+ Sbjct: 275 RMLDKNPESRIVVPEIKLHPW 295 >5J5T-A nrPDB Length = 370 Score = 232 bits (592), Expect = 2e-61, Method: Composition-based stats. Identities = 60/299 (20%), Positives = 124/299 (41%), Gaps = 46/299 (15%) Query: 34 GNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKI---KREIKILENLRG 90 G+Q+D++L++++G G Y +V++A N+ E +K++K + ++EI ++++ + Sbjct: 1 GSQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKH 60 Query: 91 GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ---TLTDYDIRFYMYEILKALDYC 147 PNI+ + E + +Y L++ I + E L+ L Y Sbjct: 61 -PNIVAYFGSY--LRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYL 117 Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGL-AEFYHPGQEYNVRVASRYFKGPEL--LV 204 HS G MHRD+K N+++ ++ ++L D+G+ A+ + + + Y+ PE+ + Sbjct: 118 HSKGKMHRDIKGANILLT-DNGHVKLADFGVSAQITATIAKRKAFIGTPYWMAPEVAAVE 176 Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIE 264 Y+ D+W++G + + P F H + L D + Sbjct: 177 RKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKM------ 230 Query: 265 LDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323 +W H F+ L + + R TA + ++HP+ Sbjct: 231 ---------------KWSNSFH------------HFVKMALTKNPKKRPTAEKLLQHPF 262 >3NYO-A nrPDB Length = 576 Score = 232 bits (592), Expect = 2e-61, Method: Composition-based stats. Identities = 79/339 (23%), Positives = 132/339 (38%), Gaps = 55/339 (16%) Query: 23 YWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK------KK 76 + ++ + ++ ++ R LG+G + EV + K L+ + + Sbjct: 170 FLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEA 229 Query: 77 KIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY-----QTLTDY 131 E +ILE + +++LA + LV +N D K + Sbjct: 230 MALNEKQILEKV-NSRFVVSLAYAYE--TKDALCLVLTLMNGGDLKFHIYHMGQAGFPEA 286 Query: 132 DIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVR 191 FY EI L+ H I++RD+KP N+++D +H +R+ D GLA GQ R Sbjct: 287 RAVFYAAEICCGLEDLHRERIVYRDLKPENILLD-DHGHIRISDLGLAVHVPEGQTIKGR 345 Query: 192 VASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGT 251 V + + PE++ + + Y +S D W+LGC+L MI + PF + K + Sbjct: 346 VGTVGYMAPEVVKNER-YTFSPDWWALGCLLYEMIAGQSPF----------QQRKKKIKR 394 Query: 252 EDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQS 311 E++ + + E RF SP+A +LL D Sbjct: 395 EEVERLVKEVPEEYSERF------------------------SPQARSLCSQLLCKDPAE 430 Query: 312 RL-----TAREAMEHPYFYTVVKDQARMGSSSMPGGSTP 345 RL +ARE EHP F + + G P P Sbjct: 431 RLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDP 469 >4TNB-A nrPDB Length = 590 Score = 232 bits (592), Expect = 2e-61, Method: Composition-based stats. Identities = 79/339 (23%), Positives = 126/339 (37%), Gaps = 55/339 (16%) Query: 23 YWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK----- 77 + ++ + ++ ++ R LG+G + EV + K L+ + KK Sbjct: 170 FLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGES 229 Query: 78 -IKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY-----QTLTDY 131 E +ILE + ++ LA + LV +N D K + Sbjct: 230 MALNEKQILEKV-NSQFVVNLAYAYE--TKDALCLVLTIMNGGDLKFHIYNMGNPGFEEE 286 Query: 132 DIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVR 191 FY EIL L+ H ++RD+KP N+++D ++ +R+ D GLA G R Sbjct: 287 RALFYAAEILCGLEDLHHENTVYRDLKPENILLD-DYGHIRISDLGLAVKIPEGDLIRGR 345 Query: 192 VASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGT 251 V + + PE+L + Q Y S D W LGC++ MI + PF + + +VL T Sbjct: 346 VGTVGYMAPEVL-NNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLET 404 Query: 252 EDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQS 311 E++Y H S EA LL D + Sbjct: 405 EEVY----------------------------------SHKFSEEAKSICKMLLTKDAKQ 430 Query: 312 RLT-----AREAMEHPYFYTVVKDQARMGSSSMPGGSTP 345 RL A E HP+F + + G P P Sbjct: 431 RLGCQEEEAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDP 469 >4I6B-A nrPDB Length = 308 Score = 232 bits (591), Expect = 2e-61, Method: Composition-based stats. Identities = 61/307 (19%), Positives = 128/307 (41%), Gaps = 53/307 (17%) Query: 30 VVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL------KPVKKKKIKREIK 83 +V+ Y + LG+G +++ +E ++TNN+ KI+ KP +++KI +EI+ Sbjct: 21 IVDPTTGKRYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKIDKEIE 80 Query: 84 ILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEI 140 + L +++ +D ++ E+ + + + LT+ ++R+Y+ +I Sbjct: 81 LHRIL-HHKHVVQFYHYFEDK--ENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQI 137 Query: 141 LKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHP-GQEYNVRVASRYFKG 199 + L Y H I+HRD+K N I+ E +L++ D+GLA P + + Sbjct: 138 VSGLKYLHEQEILHRDLKLGNFFIN-ESMELKVGDFGLAARLEPLEHRRRTICGTPNYLS 196 Query: 200 PELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYID 259 PE+L + Q + D+W+LGC++ +M+ + PF + ++ Y I Sbjct: 197 PEVL-NKQGHGAESDIWALGCVMYTMLLGRPPF--------------ETTNLKETYRSIR 241 Query: 260 KYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAM 319 + + A + +L + + R + + + Sbjct: 242 EARYTMPSSLL------------------------APAKHLIASMLSKNPEDRPSLDDII 277 Query: 320 EHPYFYT 326 H +F Sbjct: 278 RHDFFTQ 284 >4KS7-A nrPDB Length = 292 Score = 232 bits (591), Expect = 3e-61, Method: Composition-based stats. Identities = 63/287 (21%), Positives = 123/287 (42%), Gaps = 46/287 (16%) Query: 44 KLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK---IKREIKILENLRGGPNIITLADI 100 K+G G V A + +V VK++ K+++ + E+ I+ + + N++ + Sbjct: 30 KIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHF-NVVEMYKS 88 Query: 101 VKDPVSRTPALVFEHVNNTDFKQLYQ--TLTDYDIRFYMYEILKALDYCHSMGIMHRDVK 158 V ++ E + + L + I +L+AL Y H+ G++HRD+K Sbjct: 89 Y--LVGEELWVLMEFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIK 146 Query: 159 PHNVMIDHEHRKLRLIDWGL-AEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWS 217 ++++ + R ++L D+G A+ + V + Y+ PE++ +Y +D+WS Sbjct: 147 SDSILLTLDGR-VKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVI-SRSLYATEVDIWS 204 Query: 218 LGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHS 277 LG M+ M+ + P+F ++ + + P+ Sbjct: 205 LGIMVIEMVDGEPPYF-----------------SDSPVQAMKRLRDSPPPKLK------- 240 Query: 278 RKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 N H VSP DFL+++L D Q R TA+E ++HP+ Sbjct: 241 -----------NSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFL 276 >3Q53-A nrPDB Length = 306 Score = 231 bits (590), Expect = 3e-61, Method: Composition-based stats. Identities = 65/294 (22%), Positives = 127/294 (43%), Gaps = 46/294 (15%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPV---KKKKIKREIKILENLRGGPNI 94 Y K+G+G V+ A+++ ++V ++ + KK+ I EI ++ + PNI Sbjct: 22 KYTRFEKIGQGASGTVYTAMDVATGQEVAIRQMNLQQQPKKELIINEILVMRENKN-PNI 80 Query: 95 ITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ--TLTDYDIRFYMYEILKALDYCHSMGI 152 + D V +V E++ + + + I E L+AL++ HS + Sbjct: 81 VNYLDSY--LVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQV 138 Query: 153 MHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ-EYNVRVASRYFKGPELLVDYQMYDY 211 +HRD+K N+++ + ++L D+G P Q + + V + Y+ PE++ + Y Sbjct: 139 IHRDIKSDNILLGMDG-SVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVV-TRKAYGP 196 Query: 212 SLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFND 271 +D+WSLG M MI + P+ ++N + + + GT +L Sbjct: 197 KVDIWSLGIMAIEMIEGEPPYL--NENPLRALYLIATNGTPEL----------------- 237 Query: 272 ILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFY 325 +N +S DFL++ L D + R +A+E ++H + Sbjct: 238 ----------------QNPEKLSAIFRDFLNRCLEMDVEKRGSAKELIQHQFLK 275 >4YNZ-A nrPDB Length = 342 Score = 231 bits (590), Expect = 3e-61, Method: Composition-based stats. Identities = 79/333 (23%), Positives = 137/333 (41%), Gaps = 59/333 (17%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK-----KIKREIKILENLRGGPN 93 Y+L + LG+G+ V I+ +KV +KI+ K K++REI IL+ L P+ Sbjct: 12 YRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSESVLMKVEREIAILK-LIEHPH 70 Query: 94 IITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCHSM 150 ++ L D+ ++ + LV EHV+ + LT + R + +I+ ALD+CHS Sbjct: 71 VLKLHDVYENK--KYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSH 128 Query: 151 GIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYD 210 I HRD+KP N+++D E +R+ D+G+A S ++ PE++ + Sbjct: 129 SICHRDLKPENLLLD-ERNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDG 187 Query: 211 YSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFN 270 D+WS G +L +++ PF DN QL+ K + P F Sbjct: 188 RKADVWSCGVILFALLVGALPF--DDDNLRQLLEKV-------------KRGVFHMPHF- 231 Query: 271 DILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKD 330 + P+ L ++ D RLT +H ++ Sbjct: 232 ----------------------IPPDCQSLLRGMIEVDAARRLTLEHIQKHIWY------ 263 Query: 331 QARMGSSSMPGGSTPVSSANMMSGISSVPTPSP 363 +G + P P+ + + S+ P Sbjct: 264 ---IGGKNEPEPEQPIPRKVQIRSLPSLEDIDP 293 >6BDL-A nrPDB Length = 347 Score = 231 bits (589), Expect = 4e-61, Method: Composition-based stats. Identities = 71/344 (20%), Positives = 141/344 (40%), Gaps = 59/344 (17%) Query: 38 DYQLVRKLGRGKYSEVFEAINI-TNNEKVVVKILKP------VKKKKIKREIKILENLRG 90 D+ ++ LG G + V ++ +KILK +++ I+ E +I++ Sbjct: 35 DFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQG-AH 93 Query: 91 GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ---TLTDYDIRFYMYEILKALDYC 147 I+ L KD S+ ++ E + + + + D RFY +++A Y Sbjct: 94 SDFIVRLYRTFKD--SKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYL 151 Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQ 207 HS GI++RD+KP N+++DH +L+D+G A+ G++ + + PE++++ + Sbjct: 152 HSKGIIYRDLKPENLILDHRGYA-KLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILN-K 209 Query: 208 MYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDP 267 +D S D WSLG ++ ++ PF G D I + + D+ ++ K Sbjct: 210 GHDISADYWSLGILMYELLTGSPPF-SGPDPMKTYNIILRGI---DMIEFPKK------- 258 Query: 268 RFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRL-----TAREAMEHP 322 ++ A + + KL R + RL ++ +H Sbjct: 259 -------------------------IAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHK 293 Query: 323 YFYTVVKDQAR---MGSSSMPGGSTPVSSANMMSGISSVPTPSP 363 +F + R + +P ++P ++N S P P Sbjct: 294 WFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNDEPPP 337 >2F57-A nrPDB Length = 317 Score = 230 bits (587), Expect = 6e-61, Method: Composition-based stats. Identities = 64/288 (22%), Positives = 118/288 (40%), Gaps = 46/288 (15%) Query: 44 KLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK---IKREIKILENLRGGPNIITLADI 100 K+G G V A ++V VK + K+++ + E+ I+ + N++ + Sbjct: 52 KIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRD-YHHDNVVDMYSS 110 Query: 101 VKDPVSRTPALVFEHVNNTDFKQL--YQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVK 158 V +V E + + + + + I +L+AL Y H+ G++HRD+K Sbjct: 111 Y--LVGDELWVVMEFLEGGALTDIVTHTRMNEEQIATVCLSVLRALSYLHNQGVIHRDIK 168 Query: 159 PHNVMIDHEHRKLRLIDWGL-AEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWS 217 ++++ + R ++L D+G A+ + V + Y+ PE++ Y +D+WS Sbjct: 169 SDSILLTSDGR-IKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRL-PYGTEVDIWS 226 Query: 218 LGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHS 277 LG M+ MI + P+F+ E + + L PR D+ Sbjct: 227 LGIMVIEMIDGEPPYFN-----------------EPPLQAMRRIRDSLPPRVKDL----- 264 Query: 278 RKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFY 325 H VS FLD +L + R TA+E + HP+ Sbjct: 265 -------------HKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLK 299 >5LOH-A nrPDB Length = 341 Score = 230 bits (587), Expect = 7e-61, Method: Composition-based stats. Identities = 71/331 (21%), Positives = 126/331 (38%), Gaps = 60/331 (18%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK------KKKIKREIKILENLRG 90 +++ +V+ + RG + +V+ + VK++K +++ E L L Sbjct: 36 EEFSIVKPISRGAFGKVYLGQ--KGGKLYAVKVVKKADMINKNMTHQVQAERDALA-LSK 92 Query: 91 GPNIITLADIVKDPVSRTPALVFEHVNNTD---FKQLYQTLTDYDIRFYMYEILKALDYC 147 P I+ L ++ + LV E++ D +Y + Y+ E+ ALDY Sbjct: 93 SPFIVHLYYSLQS--ANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALALDYL 150 Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF-------YHPGQEYNVRVASRYFKGP 200 H GI+HRD+KP N++I +E ++L D+GL++ + + P Sbjct: 151 HRHGIIHRDLKPDNMLISNEGH-IKLTDFGLSKVTLNRDINMMDILTTRTFCGTPDYLAP 209 Query: 201 ELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDK 260 ELL+ + + ++D W+LG L + PF + Q+ Sbjct: 210 ELLLG-RAHGPAVDWWALGVCLFEFLTGIPPF--NDETPQQV------------------ 248 Query: 261 YNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAME 320 F +IL R E + +S A ++ LL D R +E Sbjct: 249 --------FQNILKRD-------IPWPEGEEKLSDNAQSAVEILLTIDDTKRAGMKELKR 293 Query: 321 HPYFYTVVKDQARMGSSSMPGGSTPVSSANM 351 HP F V D + +MP P + Sbjct: 294 HPLFSDV--DWENLQHQTMPFIPQPDDETDT 322 >3DB8-A nrPDB Length = 317 Score = 230 bits (586), Expect = 8e-61, Method: Composition-based stats. Identities = 67/342 (19%), Positives = 143/342 (41%), Gaps = 62/342 (18%) Query: 3 GPVPSRARVYTDVNTHRPREYWDYESH--------VVEWGNQDDYQLVRKLGRGKYSEVF 54 GP+ S + + +P + D +S +V+ Y R LG+G +++ + Sbjct: 1 GPLGSMSA-AIAKPSAKPSAHVDPKSAPLKEIPDVLVDPRTMKRYMRGRFLGKGGFAKCY 59 Query: 55 EAINITNNEKVVVKI------LKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRT 108 E ++ E K+ LKP +K+K+ EI I ++L P+++ +D Sbjct: 60 EITDMDTKEVFAGKVVPKSMLLKPHQKEKMSTEIAIHKSLDN-PHVVGFHGFFED--DDF 116 Query: 109 PALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMID 165 +V E +L++ +T+ + R++M + ++ + Y H+ ++HRD+K N+ ++ Sbjct: 117 VYVVLEICRRRSLLELHKRRKAVTEPEARYFMRQTIQGVQYLHNNRVIHRDLKLGNLFLN 176 Query: 166 HEHRKLRLIDWGLAEFYH-PGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLAS 224 + +++ D+GLA G+ + + PE+L + + + +D+WSLGC+L + Sbjct: 177 -DDMDVKIGDFGLATKIEFDGERKKDLCGTPNYIAPEVLCK-KGHSFEVDIWSLGCILYT 234 Query: 225 MIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERF 284 ++ K PF + ++ Y I K + Sbjct: 235 LLVGKPPF--------------ETSCLKETYIRIKKNEYSVP------------------ 262 Query: 285 VHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYT 326 ++P A + ++L D R + E + +F + Sbjct: 263 ------RHINPVASALIRRMLHADPTLRPSVAELLTDEFFTS 298 >4B6L-A nrPDB Length = 281 Score = 230 bits (586), Expect = 1e-60, Method: Composition-based stats. Identities = 69/309 (22%), Positives = 128/309 (41%), Gaps = 54/309 (17%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKIL------KPVKKKKIKREIKILENLRGGP 92 Y R LG+G ++ +EA + VK++ KP +++KI EI++ +L+ Sbjct: 11 YLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQH-R 69 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ---TLTDYDIRFYMYEILKALDYCHS 149 +I+ + +D + + E + +++ TL + ++R+Y+ +IL L Y H Sbjct: 70 HIVRFSHHFED--ADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQ 127 Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGL-AEFYHPGQEYNVRVASRYFKGPELLVDYQM 208 GI+HRD+K N I E+ +L++ D+GL A P Q + + PE+L+ Q Sbjct: 128 RGILHRDLKLGNFFIT-ENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLL-RQG 185 Query: 209 YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPR 268 + D+WSLGC++ +++ PF Sbjct: 186 HGPEADVWSLGCVMYTLLCGSPPF------------------------------------ 209 Query: 269 FNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF-YTV 327 + R + VH +S A L +LR + R + + + H +F Sbjct: 210 --ETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPSIDQILRHDFFTKGY 267 Query: 328 VKDQARMGS 336 D+ + S Sbjct: 268 TPDRLPISS 276 >3RAW-A nrPDB Length = 381 Score = 230 bits (586), Expect = 1e-60, Method: Composition-based stats. Identities = 78/348 (22%), Positives = 155/348 (44%), Gaps = 48/348 (13%) Query: 25 DYESHVV----EWGNQDDYQLVRKLGRGKYSEVFEAINITNNE-KVVVKILKPV--KKKK 77 D E H+V +W Q+ Y++V LG G + +V E ++ + +V +KI++ V ++ Sbjct: 36 DKEGHLVCRIGDW-LQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREA 94 Query: 78 IKREIKILENLR--GGPN---IITLADIVKDPVSRTPALVFEHVNNTDFKQL----YQTL 128 + EI +L+ ++ N + ++D + FE + F+ L +Q Sbjct: 95 ARLEINVLKKIKEKDKENKFLCVLMSDWF--NFHGHMCIAFELLGKNTFEFLKENNFQPY 152 Query: 129 TDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMI------------------DHEHRK 170 +R Y++ AL + H + H D+KP N++ ++ Sbjct: 153 PLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTS 212 Query: 171 LRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKE 230 +R+ D+G A F + + VA+R+++ PE++++ + D+WS+GC+L +R Sbjct: 213 IRVADFGSATF--DHEHHTTIVATRHYRPPEVILEL-GWAQPCDVWSIGCILFEY-YRGF 268 Query: 231 PFFHGHDNYDQLVRIAKVLGTEDLYDYIDK------YNIELDPRFNDILGRHSRKRWERF 284 F H+N + LV + K+LG + Y L N GR+ ++ + Sbjct: 269 TLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPL 328 Query: 285 VHSENQHLV-SPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQ 331 Q + + D + ++L +D R+T EA+ HP+F + ++ Sbjct: 329 KSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEE 376 >3PFQ-A nrPDB Length = 674 Score = 229 bits (585), Expect = 1e-60, Method: Composition-based stats. Identities = 76/358 (21%), Positives = 124/358 (34%), Gaps = 66/358 (18%) Query: 34 GNQD-----DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPV------KKKKIKREI 82 GN+D D+ + LG+G + +V + +E VKILK + E Sbjct: 333 GNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEK 392 Query: 83 KILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ---TLTDYDIRFYMYE 139 ++L P + L + V E+VN D Q + FY E Sbjct: 393 RVLALPGKPPFLTQLHSCFQ--TMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAE 450 Query: 140 ILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF-YHPGQEYNVRVASRYFK 198 I L + S GI++RD+K NVM+D E +++ D+G+ + G + + Sbjct: 451 IAIGLFFLQSKGIIYRDLKLDNVMLDSEGH-IKIADFGMCKENIWDGVTTKTFCGTPDYI 509 Query: 199 GPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYI 258 PE++ YQ Y S+D W+ G +L M+ + PF G D + I + Sbjct: 510 APEIIA-YQPYGKSVDWWAFGVLLYEMLAGQAPF-EGEDEDELFQSIME----------- 556 Query: 259 DKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTA--- 315 + +S EA+ L+ RL Sbjct: 557 --------------------------HNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPE 590 Query: 316 --REAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLGPLAGSP 371 R+ EH +F + ++ P P +S T P P+ P Sbjct: 591 GERDIKEHAFFRYIDWEKLERKEIQPP--YKPKASGRNAENFDRFFTRHP--PVLTPP 644 >5DYK-A nrPDB Length = 853 Score = 229 bits (584), Expect = 1e-60, Method: Composition-based stats. Identities = 71/335 (21%), Positives = 135/335 (40%), Gaps = 56/335 (16%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVK------ILKPVKKKKIKREIKILENLR 89 D+ + R +GRG + V + + +K I+ ++ IK E +I Sbjct: 538 MDELETERIIGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINLNQQNNIKLEREITAE-N 596 Query: 90 GGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTL---TDYDIRFYMYEILKALDY 146 P II L KD S+ + E V + + L + +FY+ I+ A++Y Sbjct: 597 DHPFIIRLVRTFKD--SKYFYFLTELVTGGELYDAIRKLGLLSKSQAQFYLGSIILAIEY 654 Query: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDY 206 H I++RD+KP N+++D + ++LID+G A+ G+ Y V + ++ PE+++ Sbjct: 655 LHERNIVYRDLKPENILLDKQGY-VKLIDFGCAKKVQ-GRAYT-LVGTPHYMAPEVILG- 710 Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 266 + Y ++D+W+LG L I PF G+D DQL +L + + Sbjct: 711 KGYGCTVDIWALGICLYEFICGPLPF--GNDEEDQLEIFRDILTGQLTFP---------- 758 Query: 267 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTA-----REAMEH 321 ++ ++++ + +LL Q R+ ++ +H Sbjct: 759 -----------------------DYVTDTDSINLMKRLLCRLPQGRIGCSINGFKDIKDH 795 Query: 322 PYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGIS 356 P+F D+ P S + A + Sbjct: 796 PFFSNFNWDKLAGRLLDPPLVSKSETYAEDIDIKQ 830 >6E9W-A nrPDB Length = 443 Score = 229 bits (584), Expect = 2e-60, Method: Composition-based stats. Identities = 73/353 (20%), Positives = 128/353 (36%), Gaps = 64/353 (18%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVK------ILKPVKKKKIKREIKILENLRG 90 +DY++V+ +GRG + EV + + + +K ++K E I+ Sbjct: 102 EDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMA-FAN 160 Query: 91 GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTL--TDYDIRFYMYEILKALDYCH 148 P ++ L +D R +V E++ D L + RFY E++ ALD H Sbjct: 161 SPWVVQLFYAFQD--DRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDAIH 218 Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHP--GQEYNVRVASRYFKGPELLV-- 204 SMG +HRDVKP N+++D L+L D+G + + V + + PE+L Sbjct: 219 SMGFIHRDVKPDNMLLDKSGH-LKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQ 277 Query: 205 -DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNI 263 Y D WS+G L M+ PF+ ++GT Sbjct: 278 GGDGYYGRECDWWSVGVFLYEMLVGDTPFYADS-----------LVGTYSKIMNH----- 321 Query: 264 ELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRL---TAREAME 320 + + + + +S EA + + L D + RL E Sbjct: 322 ------------------KNSLTFPDDNDISKEAKNLICAFLT-DREVRLGRNGVEEIKR 362 Query: 321 HPYFYTVVKDQARMG---SSSMPGGSTPVSSANMMS------GISSVPTPSPL 364 H +F + + +P S+ + ++N + P P Sbjct: 363 HLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEEDKGEEETFPIPKAF 415 >5DBX-A nrPDB Length = 328 Score = 228 bits (582), Expect = 3e-60, Method: Composition-based stats. Identities = 62/353 (17%), Positives = 126/353 (35%), Gaps = 56/353 (15%) Query: 28 SHVVEWGN-QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK----KIKREI 82 + V W +D Y+L +G G + V A+ E+V +K + K + ++ +EI Sbjct: 1 AQAVGWPICRDAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEI 60 Query: 83 KILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ-----------TLTDY 131 + + PN++T V LV + ++ + + L + Sbjct: 61 QAMSQCSH-PNVVTYYTSF--VVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEA 117 Query: 132 DIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPG------ 185 I + E+L+ LDY H G +HRD+K N+++ + +++ D+G++ F G Sbjct: 118 IIATILKEVLEGLDYLHRNGQIHRDLKAGNILLGEDG-SVQIADFGVSAFLATGGDVTRN 176 Query: 186 QEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRI 245 + V + + PE++ + YD+ DMWS G + P+ Sbjct: 177 KVRKDFVGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYH------------ 224 Query: 246 AKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLL 305 + + + + + K++ + L L Sbjct: 225 ----KYPPMKVLMLTLQNDPPTLETGVEDKEMMKKYGK------------SFRKLLSLCL 268 Query: 306 RYDHQSRLTAREAMEHPYFYTVVKDQARMGS--SSMPGGSTPVSSANMMSGIS 356 + D R TA E ++ +F + + + P + + G S Sbjct: 269 QKDPSKRPTAAELLKCKFFQKAKNREYLIEKLLTRTPDIAQRAKKVRRVPGSS 321 >6ED6-A nrPDB Length = 415 Score = 228 bits (581), Expect = 3e-60, Method: Composition-based stats. Identities = 74/353 (20%), Positives = 130/353 (36%), Gaps = 64/353 (18%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVK------ILKPVKKKKIKREIKILENLRG 90 +DY +V+ +GRG + EV + + + +K ++K E I+ Sbjct: 88 EDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMA-FAN 146 Query: 91 GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTL--TDYDIRFYMYEILKALDYCH 148 P ++ L +D R +V E++ D L + +FY E++ ALD H Sbjct: 147 SPWVVQLFYAFQD--DRYLYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALDAIH 204 Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ--EYNVRVASRYFKGPELLVDY 206 SMG++HRDVKP N+++D +H L+L D+G + V + + PE+L Sbjct: 205 SMGLIHRDVKPDNMLLD-KHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQ 263 Query: 207 QM---YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNI 263 Y D WS+G L M+ PF+ + Y+ Sbjct: 264 GGDGFYGRECDWWSVGVFLYEMLVGDTPFYADS--------------------LVGTYSK 303 Query: 264 ELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRL---TAREAME 320 +D + + + +S A + + L D + RL E + Sbjct: 304 IMDHKNSLCFPEDA--------------EISKHAKNLICAFLT-DREVRLGRNGVEEIRQ 348 Query: 321 HPYFYTVVKDQ---ARMGSSSMPGGSTPVSSANMMSG------ISSVPTPSPL 364 HP+F + +P S+ + S+N + + P P Sbjct: 349 HPFFKNDQWHWDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVETFPIPKAF 401 >3HKO-A nrPDB Length = 345 Score = 228 bits (581), Expect = 4e-60, Method: Composition-based stats. Identities = 74/358 (20%), Positives = 129/358 (36%), Gaps = 95/358 (26%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKI--------LKPVKKKKIKREIKILEN 87 Q Y L +G+G Y V AI +KI + P ++IK E+++++ Sbjct: 25 QKKYHLKGAIGQGSYGVVRVAIENQTRAIRAIKIMNKNKIRQINPKDVERIKTEVRLMKK 84 Query: 88 LRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTL------------------- 128 L PNI L ++ +D + LV E + Sbjct: 85 L-HHPNIARLYEVYED--EQYICLVMELCHGGHLLDKLNVFIDDSTGKCAMDVVKTQICP 141 Query: 129 ------------------------TDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMI 164 + I M +I AL Y H+ GI HRD+KP N + Sbjct: 142 CPECNEEAINGSIHGFRESLDFVQREKLISNIMRQIFSALHYLHNQGICHRDIKPENFLF 201 Query: 165 D-HEHRKLRLIDWGLAEFY---HPGQEY--NVRVASRYFKGPELLV-DYQMYDYSLDMWS 217 ++ +++L+D+GL++ + + G+ Y + + YF PE+L + Y D WS Sbjct: 202 STNKSFEIKLVDFGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEVLNTTNESYGPKCDAWS 261 Query: 218 LGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHS 277 G +L ++ PF G ++ D + ++ Sbjct: 262 AGVLLHLLLMGAVPF-PGVNDADTISQVLN------------------------------ 290 Query: 278 RKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMG 335 + + N +++SP A D L LL + R A A++HP+ +M Sbjct: 291 ---KKLCFENPNYNVLSPLARDLLSNLLNRNVDERFDAMRALQHPWISQFSDKIYKMS 345 >5UNP-A nrPDB Length = 369 Score = 227 bits (580), Expect = 4e-60, Method: Composition-based stats. Identities = 74/340 (21%), Positives = 147/340 (43%), Gaps = 44/340 (12%) Query: 28 SHVVEWGNQDDYQLVRKLGRGKYSEVFEAI-NITNNEKVVVKILKPVKK--KKIKREIKI 84 HV +W Q+ Y++V LG G + V + + + +V +KI+K V+K + + EI + Sbjct: 26 YHVGDW-LQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINV 84 Query: 85 LENLR----GGPNI-ITLADIVKDPVSRTPALVFEHVNNTDFKQL----YQTLTDYDIRF 135 LE + N+ + + D + FE + + F L Y + +R Sbjct: 85 LEKINEKDPDNKNLCVQMFDWF--DYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRH 142 Query: 136 YMYEILKALDYCHSMGIMHRDVKPHNVMI------------------DHEHRKLRLIDWG 177 +++ +A+ + H + H D+KP N++ + +R++D+G Sbjct: 143 MAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFG 202 Query: 178 LAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHD 237 A F + ++ V++R+++ PE++++ + D+WS+GC++ F HD Sbjct: 203 SATF--DHEHHSTIVSTRHYRAPEVILEL-GWSQPCDVWSIGCIIFEYYVGFT-LFQTHD 258 Query: 238 NYDQLVRIAKVLGTEDLYDYIDK------YNIELDPRFNDILGRHSRKRWERFVHSENQH 291 N + L + ++LG Y LD N GR+ R+ + Sbjct: 259 NREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSE 318 Query: 292 -LVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKD 330 + D ++ +L Y+ RLT EA++HP+F + + Sbjct: 319 AEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAE 358 >2X7G-A nrPDB Length = 389 Score = 227 bits (580), Expect = 5e-60, Method: Composition-based stats. Identities = 83/387 (21%), Positives = 151/387 (39%), Gaps = 77/387 (19%) Query: 14 DVNTHRPREYWDYESHVVEWGN--QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK 71 D P +Y H V+ G+ Y ++RKLG G +S V+ ++ V +K++K Sbjct: 6 DEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVK 65 Query: 72 PVKK--KKIKREIKILENLR----GGPN---IITLADIVK--DPVSRTPALVFEHVNNTD 120 + + EIK+L+ +R PN ++ L D K +VFE + + Sbjct: 66 SAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHL 125 Query: 121 FKQL----YQTLTDYDIRFYMYEILKALDYCHSM-GIMHRDVKPHNVMI----------- 164 K + YQ L ++ + ++L+ LDY HS I+H D+KP N+++ Sbjct: 126 LKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMA 185 Query: 165 -----------------------------------DHEHRKLRLIDWGLAEFYHPGQEYN 189 + + ++++ D G A + H + + Sbjct: 186 AEATEWQKAGAPPPSGSAVSTAPAADLLVNPLDPRNADKIRVKIADLGNACWVH--KHFT 243 Query: 190 VRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFH--GHD---NYDQLVR 244 + +R ++ E+L+ Y D+WS CM + F G D + D + Sbjct: 244 EDIQTRQYRSIEVLIGA-GYSTPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAH 302 Query: 245 IAKVLGT-EDLYDYIDKYNIELDPRFNDILGRHSRKRWERF----VHSENQHLVSPEALD 299 I ++LG+ + KY+ E R ++ K W F H + + D Sbjct: 303 IIELLGSIPRHFALSGKYSREFFNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTD 362 Query: 300 FLDKLLRYDHQSRLTAREAMEHPYFYT 326 FL +L + R +A E + HP+ + Sbjct: 363 FLIPMLEMVPEKRASAGECLRHPWLNS 389 >2I0E-A nrPDB Length = 353 Score = 227 bits (578), Expect = 8e-60, Method: Composition-based stats. Identities = 75/358 (20%), Positives = 123/358 (34%), Gaps = 66/358 (18%) Query: 34 GNQD-----DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPV------KKKKIKREI 82 GN+D D+ + LG+G + +V + +E VKILK + E Sbjct: 12 GNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEK 71 Query: 83 KILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ---TLTDYDIRFYMYE 139 ++L P + L + V E+VN D Q + FY E Sbjct: 72 RVLALPGKPPFLTQLHSCFQ--TMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAE 129 Query: 140 ILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF-YHPGQEYNVRVASRYFK 198 I L + S GI++RD+K NVM+D E +++ D+G+ + G + + Sbjct: 130 IAIGLFFLQSKGIIYRDLKLDNVMLDSEGH-IKIADFGMCKENIWDGVTTKTFCGTPDYI 188 Query: 199 GPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYI 258 PE++ YQ Y S+D W+ G +L M+ + PF G D + I + Sbjct: 189 APEIIA-YQPYGKSVDWWAFGVLLYEMLAGQAPF-EGEDEDELFQSIME----------- 235 Query: 259 DKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTA--- 315 + +S EA+ L+ RL Sbjct: 236 --------------------------HNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPE 269 Query: 316 --REAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLGPLAGSP 371 R+ EH +F + ++ P P + T P P+ P Sbjct: 270 GERDIKEHAFFRYIDWEKLERKEIQPP--YKPKACGRNAENFDRFFTRHP--PVLTPP 323 >4JDH-A nrPDB Length = 346 Score = 226 bits (576), Expect = 1e-59, Method: Composition-based stats. Identities = 71/332 (21%), Positives = 133/332 (40%), Gaps = 49/332 (14%) Query: 1 MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDY--QLVRKLGRGKYSEVFEAIN 58 M P + ++ VV+ G+ Y ++ +G G V A Sbjct: 37 MPEKPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIK-IGEGSTGIVCIATV 95 Query: 59 ITNNEKVVVKILKPVKKKK---IKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEH 115 ++ + V VK + K+++ + E+ I+ + + N++ + + V +V E Sbjct: 96 RSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQH-ENVVEMYNSY--LVGDELWVVMEF 152 Query: 116 VNNTDFKQL--YQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRL 173 + + + + + I +L+AL H+ G++HRD+K ++++ H+ R ++L Sbjct: 153 LEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGR-VKL 211 Query: 174 IDWGL-AEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPF 232 D+G A+ V + Y+ PEL+ Y +D+WSLG M+ M+ + P+ Sbjct: 212 SDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRL-PYGPEVDIWSLGIMVIEMVDGEPPY 270 Query: 233 FHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHL 292 F+ E + L PR ++ H Sbjct: 271 FN-----------------EPPLKAMKMIRDNLPPRLKNL------------------HK 295 Query: 293 VSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 VSP FLD+LL D R TA E ++HP+ Sbjct: 296 VSPSLKGFLDRLLVRDPAQRATAAELLKHPFL 327 >4FIE-A nrPDB Length = 423 Score = 226 bits (576), Expect = 1e-59, Method: Composition-based stats. Identities = 71/332 (21%), Positives = 133/332 (40%), Gaps = 49/332 (14%) Query: 1 MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDY--QLVRKLGRGKYSEVFEAIN 58 M P + ++ VV+ G+ Y ++ +G G V A Sbjct: 114 MPEKPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIK-IGEGSTGIVCIATV 172 Query: 59 ITNNEKVVVKILKPVKKKK---IKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEH 115 ++ + V VK + K+++ + E+ I+ + + N++ + + V +V E Sbjct: 173 RSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQH-ENVVEMYNSY--LVGDELWVVMEF 229 Query: 116 VNNTDFKQL--YQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRL 173 + + + + + I +L+AL H+ G++HRD+K ++++ H+ R ++L Sbjct: 230 LEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGR-VKL 288 Query: 174 IDWGL-AEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPF 232 D+G A+ V + Y+ PEL+ Y +D+WSLG M+ M+ + P+ Sbjct: 289 SDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRL-PYGPEVDIWSLGIMVIEMVDGEPPY 347 Query: 233 FHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHL 292 F+ E + L PR ++ H Sbjct: 348 FN-----------------EPPLKAMKMIRDNLPPRLKNL------------------HK 372 Query: 293 VSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 VSP FLD+LL D R TA E ++HP+ Sbjct: 373 VSPSLKGFLDRLLVRDPAQRATAAELLKHPFL 404 >4XBR-A nrPDB Length = 366 Score = 225 bits (574), Expect = 3e-59, Method: Composition-based stats. Identities = 66/287 (22%), Positives = 121/287 (42%), Gaps = 46/287 (16%) Query: 44 KLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK---IKREIKILENLRGGPNIITLADI 100 K+G G V A ++ + V VK + K+++ + E+ I+ + + N++ + + Sbjct: 101 KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQH-ENVVEMYNS 159 Query: 101 VKDPVSRTPALVFEHVNNTDFKQL--YQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVK 158 V +V E + + + + + I +L+AL H+ G++HRD+K Sbjct: 160 Y--LVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIK 217 Query: 159 PHNVMIDHEHRKLRLIDWGL-AEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWS 217 ++++ H+ R ++L D+G A+ V + Y+ PEL+ Y +D+WS Sbjct: 218 SDSILLTHDGR-VKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRL-PYGPEVDIWS 275 Query: 218 LGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHS 277 LG M+ M+ + P+F+ E + L PR ++ Sbjct: 276 LGIMVIEMVDGEPPYFN-----------------EPPLKAMKMIRDNLPPRLKNL----- 313 Query: 278 RKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 H VSP FLD+LL D R TA E ++HP+ Sbjct: 314 -------------HKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFL 347 >1TKI-A nrPDB Length = 321 Score = 224 bits (572), Expect = 4e-59, Method: Composition-based stats. Identities = 68/301 (22%), Positives = 135/301 (44%), Gaps = 45/301 (14%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKI--KREIKILENLRGGPNI 94 + Y + LGRG++ V + ++ + + K +K ++ K+EI IL N+ NI Sbjct: 5 EKYMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVKGTDQVLVKKEISIL-NIARHRNI 63 Query: 95 ITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----LTDYDIRFYMYEILKALDYCHSM 150 + L + + ++FE ++ D + T L + +I Y++++ +AL + HS Sbjct: 64 LHLHESFESM--EELVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCEALQFLHSH 121 Query: 151 GIMHRDVKPHNVMI-DHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMY 209 I H D++P N++ +++I++G A PG + + + + PE+ + + Sbjct: 122 NIGHFDIRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLFTAPEYYAPEV-HQHDVV 180 Query: 210 DYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRF 269 + DMWSLG ++ ++ PF + I ++ E +D Sbjct: 181 STATDMWSLGTLVYVLLSGINPFLAETNQQ----IIENIMNAEYTFD------------- 223 Query: 270 NDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 329 E +S EA+DF+D+LL + +SR+TA EA++HP+ ++ Sbjct: 224 -----------------EEAFKEISIEAMDFVDRLLVKERKSRMTASEALQHPWLKQKIE 266 Query: 330 D 330 Sbjct: 267 R 267 >2Q0N-A nrPDB Length = 301 Score = 224 bits (572), Expect = 4e-59, Method: Composition-based stats. Identities = 66/287 (22%), Positives = 121/287 (42%), Gaps = 46/287 (16%) Query: 44 KLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK---IKREIKILENLRGGPNIITLADI 100 K+G G V A ++ + V VK + K+++ + E+ I+ + + N++ + + Sbjct: 36 KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQH-ENVVEMYNS 94 Query: 101 VKDPVSRTPALVFEHVNNTDFKQL--YQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVK 158 V +V E + + + + + I +L+AL H+ G++HRD+K Sbjct: 95 Y--LVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIK 152 Query: 159 PHNVMIDHEHRKLRLIDWGL-AEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWS 217 ++++ H+ R ++L D+G A+ V + Y+ PEL+ Y +D+WS Sbjct: 153 SDSILLTHDGR-VKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRL-PYGPEVDIWS 210 Query: 218 LGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHS 277 LG M+ M+ + P+F+ E + L PR ++ Sbjct: 211 LGIMVIEMVDGEPPYFN-----------------EPPLKAMKMIRDNLPPRLKNL----- 248 Query: 278 RKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 H VSP FLD+LL D R TA E ++HP+ Sbjct: 249 -------------HKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFL 282 >4C0T-A nrPDB Length = 974 Score = 224 bits (572), Expect = 4e-59, Method: Composition-based stats. Identities = 80/358 (22%), Positives = 133/358 (37%), Gaps = 66/358 (18%) Query: 35 NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVK------ILKPVKKKKIKREIKILENL 88 N D++ ++LG G YS V A + ++ VK I+K K K + E L L Sbjct: 264 NVTDFKFGKELGEGSYSTVILATDKITGKQYAVKVLDKRHIIKEKKVKYVNIEKHALNRL 323 Query: 89 RGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ---TLTDYDIRFYMYEILKALD 145 +I+L +D S V ++ +N + L + TL + R + +IL A+ Sbjct: 324 SNRLGVISLYFTFQDKDS--LYFVLDYASNGELLTLIKRYNTLNEECTRHFGAQILDAIK 381 Query: 146 YCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHP----------GQEYNVRVASR 195 Y H G++HRD+KP N+++D + ++++ D+G A V + Sbjct: 382 YMHDNGVIHRDLKPENILLD-DKMRIQITDFGTARLLEKKNDESEEYPVDVRAKSFVGTA 440 Query: 196 YFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLY 255 + PELL + + D+W+ GC++ MI K PF ++ + Sbjct: 441 EYVSPELLEN-KYCGKPGDVWAFGCIIYQMIAGKPPFKATNEYL--------------TF 485 Query: 256 DYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTA 315 I K F I+ D + K+L R T Sbjct: 486 QKITKLQFAFSAGFPTII------------------------RDLIKKILVLQPSRRATI 521 Query: 316 REAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLGPLAGSPVI 373 E +H +F +V S P P M+ S + P L + VI Sbjct: 522 PEIQKHYFFQSVDFKDFDSIWLSDPPEIGP----YKMTAKSMMKVPE-LNKAPITTVI 574 >4U41-A nrPDB Length = 332 Score = 223 bits (568), Expect = 1e-58, Method: Composition-based stats. Identities = 62/309 (20%), Positives = 120/309 (38%), Gaps = 53/309 (17%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK--IKREIKILENLRGGPNIIT 96 ++LV +G G Y +V++ ++ + +K++ + ++ IK EI +L+ NI T Sbjct: 26 FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKKYSHHRNIAT 85 Query: 97 LADIV--KDPVSRT--PALVFEHVNNTDFKQLYQ-----TLTDYDIRFYMYEILKALDYC 147 K P LV E L + TL + I + EIL+ L + Sbjct: 86 YYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAHL 145 Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGL-AEFYHPGQEYNVRVASRYFKGPELLVDY 206 H ++HRD+K NV++ E+ +++L+D+G+ A+ N + + Y+ PE++ Sbjct: 146 HIHHVIHRDIKGQNVLLT-ENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACD 204 Query: 207 QM----YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYN 262 + YDY D+WS G M P H Sbjct: 205 ENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMH-------------------------- 238 Query: 263 IELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHP 322 R ++ R+ R + S+ ++ L ++ R + + ++HP Sbjct: 239 ---PMRALFLIPRNPPPRLKSKKWSKKFFSF-------IEGCLVKNYMQRPSTEQLLKHP 288 Query: 323 YFYTVVKDQ 331 + ++ Sbjct: 289 FIRDQPNER 297 >4QMW-A nrPDB Length = 310 Score = 222 bits (566), Expect = 2e-58, Method: Composition-based stats. Identities = 66/329 (20%), Positives = 128/329 (38%), Gaps = 55/329 (16%) Query: 3 GPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNN 62 GP+ S ++ V + P ++ ++ + + K+G+G + EVF+ I+ Sbjct: 1 GPLGSEFMAHSPVQSGLP------GMQNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQ 54 Query: 63 EKVVVKILK----PVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNN 118 + V +KI+ + + I++EI +L P + ++ E++ Sbjct: 55 KVVAIKIIDLEEAEDEIEDIQQEITVLSQC-DSPYVTKYYGSYLKDT--KLWIIMEYLGG 111 Query: 119 TDFKQLYQT--LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDW 176 L + L + I + EILK LDY HS +HRD+K NV++ EH +++L D+ Sbjct: 112 GSALDLLEPGPLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLL-SEHGEVKLADF 170 Query: 177 GLAEFYHPGQ-EYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHG 235 G+A Q + N V + ++ PE++ YD D+WSLG + + P Sbjct: 171 GVAGQLTDTQIKRNTFVGTPFWMAPEVI-KQSAYDSKADIWSLGITAIELARGEPP---- 225 Query: 236 HDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSP 295 +++ + + S Sbjct: 226 ---------------------------------HSELHPMKVLFLIPKNNPPTLEGNYSK 252 Query: 296 EALDFLDKLLRYDHQSRLTAREAMEHPYF 324 +F++ L + R TA+E ++H + Sbjct: 253 PLKEFVEACLNKEPSFRPTAKELLKHKFI 281 >4CRL-A nrPDB Length = 406 Score = 222 bits (566), Expect = 2e-58, Method: Composition-based stats. Identities = 78/321 (24%), Positives = 149/321 (46%), Gaps = 40/321 (12%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEK--VVVKILKPVKKKK-IKREIKILENLRGGPNI 94 +Y+ + GRG Y V++A + +K ++ REI +L L+ PN+ Sbjct: 24 EYEGCKV-GRGTYGHVYKAKRKDGKDDKDYALKQIEGTGISMSACREIALLRELKH-PNV 81 Query: 95 ITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ------------TLTDYDIRFYMYEILK 142 I+L + R L+F++ + D + + L ++ +Y+IL Sbjct: 82 ISLQKVFLSHADRKVWLLFDYAEH-DLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILD 140 Query: 143 ALDYCHSMGIMHRDVKPHNVMI---DHEHRKLRLIDWGLAEFYH----PGQEYNVRVASR 195 + Y H+ ++HRD+KP N+++ E ++++ D G A ++ P + + V + Sbjct: 141 GIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTF 200 Query: 196 YFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNY--------DQLVRIAK 247 +++ PELL+ + Y ++D+W++GC+ A ++ + F ++ DQL RI Sbjct: 201 WYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFN 260 Query: 248 VLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWER--FVHSENQHLVSPE--ALDFLDK 303 V+G D+ D I+ P + ++ R + + +H V P+ A L K Sbjct: 261 VMGFPADKDWED---IKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQK 317 Query: 304 LLRYDHQSRLTAREAMEHPYF 324 LL D R+T+ +AM+ PYF Sbjct: 318 LLTMDPIKRITSEQAMQDPYF 338 >2XIK-A nrPDB Length = 294 Score = 222 bits (566), Expect = 2e-58, Method: Composition-based stats. Identities = 63/302 (20%), Positives = 118/302 (39%), Gaps = 49/302 (16%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK----PVKKKKIKREIKILENLRGG 91 ++ + + ++G+G + EV++ I+ E V +KI+ + + I++EI +L Sbjct: 18 EELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQC-DS 76 Query: 92 PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT--LTDYDIRFYMYEILKALDYCHS 149 P I ++ E++ L + L + I + EILK LDY HS Sbjct: 77 PYITRYFGSYLKST--KLWIIMEYLGGGSALDLLKPGPLEETYIATILREILKGLDYLHS 134 Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ-EYNVRVASRYFKGPELLVDYQM 208 +HRD+K NV++ E ++L D+G+A Q + N V + ++ PE++ Sbjct: 135 ERKIHRDIKAANVLL-SEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI-KQSA 192 Query: 209 YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPR 268 YD+ D+WSLG + + P Sbjct: 193 YDFKADIWSLGITAIELAKGEPP------------------------------------- 215 Query: 269 FNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVV 328 +D+ + + S +F++ L D + R TA+E ++H + Sbjct: 216 NSDLHPMRVLFLIPKNSPPTLEGQHSKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYT 275 Query: 329 KD 330 K Sbjct: 276 KK 277 >5FET-A nrPDB Length = 847 Score = 222 bits (565), Expect = 2e-58, Method: Composition-based stats. Identities = 72/348 (20%), Positives = 136/348 (39%), Gaps = 61/348 (17%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVK------ILKPVKKKKIKREIKILENLR 89 + + R +GRG + V + + +K I+ ++ IK E +I Sbjct: 532 MHELETERIIGRGTFGTVKLVHHKPTQIRYALKCVSKRSIISLNQQNNIKLEREITAE-N 590 Query: 90 GGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTL---TDYDIRFYMYEILKALDY 146 P II L KD S + E V + + L + +FY+ I+ A++Y Sbjct: 591 DHPFIIRLVRTFKD--SNCFYFLTELVTGGELYDAIRKLGLLSKPQAQFYLGSIILAIEY 648 Query: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDY 206 H I++RD+KP N+++D + ++LID+G A+ G+ Y V + ++ PE+++ Sbjct: 649 LHERNIVYRDLKPENILLDKQGY-VKLIDFGCAKKIQ-GRAYT-LVGTPHYMAPEVILG- 704 Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 266 + Y ++D+W+LG L I PF G+D DQL +L + + Sbjct: 705 KGYGCTVDIWALGVCLYEFICGPLPF--GNDQEDQLEIFRDILTGQLTFP---------- 752 Query: 267 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTA-----REAMEH 321 ++ ++++ + +LL Q R+ ++ EH Sbjct: 753 -----------------------DYVSDQDSINLMKRLLCRLPQGRIGCSINGFKDIKEH 789 Query: 322 PYFYTVVKDQARMGSSSMPGGSTPVSSA-----NMMSGISSVPTPSPL 364 +F D+ P S + A + ++ PL Sbjct: 790 AFFGNFNWDKLAGRLLEPPLVSKGETYAEDIDIKQIEEEDALNEGEPL 837 >3VN9-A nrPDB Length = 340 Score = 222 bits (565), Expect = 2e-58, Method: Composition-based stats. Identities = 68/341 (19%), Positives = 138/341 (40%), Gaps = 62/341 (18%) Query: 5 VPSRARVYTDVNTHRPREYWDYESHVVEWGNQ------DDYQLVRKLGRGKYSEVFEAIN 58 +P A ++ PR+ + GNQ DD + + +LGRG Y V + + Sbjct: 15 IPKEAFEQPQTSSTPPRDL--DSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRH 72 Query: 59 ITNNEKVVVKILK----PVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFE 114 + + + + VK ++ ++K++ ++ I P +T + + E Sbjct: 73 VPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGD--VWICME 130 Query: 115 HVNNTDFKQLY-------QTLTDYDIRFYMYEILKALDYCHSM-GIMHRDVKPHNVMIDH 166 ++ T + Y QT+ + + I+KAL++ HS ++HRDVKP NV+I+ Sbjct: 131 LMD-TSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINA 189 Query: 167 EHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELL---VDYQMYDYSLDMWSLGCMLA 223 ++++ D+G++ + + + + PE + ++ + Y D+WSLG + Sbjct: 190 -LGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMI 248 Query: 224 SMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWER 283 + + P+ + QL ++ + E P+ Sbjct: 249 ELAILRFPYDSWGTPFQQLKQVVE----------------EPSPQLP------------- 279 Query: 284 FVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 S E +DF + L+ + + R T E M+HP+F Sbjct: 280 ------ADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFF 314 >4WNO-A nrPDB Length = 287 Score = 221 bits (563), Expect = 4e-58, Method: Composition-based stats. Identities = 57/213 (26%), Positives = 106/213 (49%), Gaps = 22/213 (10%) Query: 38 DYQLVRK--LGRGKYSEVFEAINITNNE-KVVVKILKPVKKKKIK----REIKILENLRG 90 ++ RK +G G ++ VF+ + ++ +V VK + K + +EIKIL+ L+ Sbjct: 17 KFEFSRKDLIGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKH 76 Query: 91 GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYC 147 NI+ L D + ++ + LV E+ N D +TL++ IR ++ +I A+ Sbjct: 77 -ENIVALYDFQE--MANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLL 133 Query: 148 HSMGIMHRDVKPHNVMIDHEHR--------KLRLIDWGLAEFYHPGQEYNVRVASRYFKG 199 HS GI+HRD+KP N+++ + ++++ D+G A + S + Sbjct: 134 HSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMA 193 Query: 200 PELLVDYQMYDYSLDMWSLGCMLASMIFRKEPF 232 PE+++ Q YD D+WS+G ++ + K PF Sbjct: 194 PEVIMS-QHYDGKADLWSIGTIVYQCLTGKAPF 225 >2OU7-A nrPDB Length = 335 Score = 221 bits (563), Expect = 4e-58, Method: Composition-based stats. Identities = 65/330 (19%), Positives = 140/330 (42%), Gaps = 54/330 (16%) Query: 45 LGRGKYSEVFEAINITNNEKVVVKI------LKPVKKKKIKREIKILENLRGGPNIITLA 98 LG+G +++ FE + E KI LKP +++K+ EI I +L +++ Sbjct: 49 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQ-HVVGFH 107 Query: 99 DIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYCHSMGIMHR 155 +D + +V E +L++ LT+ + R+Y+ +I+ Y H ++HR Sbjct: 108 GFFED--NDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHR 165 Query: 156 DVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLD 214 D+K N+ ++ E ++++ D+GLA + + G+ V + + PE+L + + + +D Sbjct: 166 DLKLGNLFLN-EDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVL-SKKGHSFEVD 223 Query: 215 MWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILG 274 +WS+GC++ +++ K PF + ++ Y I K + Sbjct: 224 VWSIGCIMYTLLVGKPPF--------------ETSCLKETYLRIKKNEYSIPKH------ 263 Query: 275 RHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYT-VVKDQAR 333 ++P A + K+L+ D +R T E + +F + + + Sbjct: 264 ------------------INPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLP 305 Query: 334 MGSSSMPGGSTPVSSANMMSGISSVPTPSP 363 + ++P + S+ S + + Sbjct: 306 ITCLTIPPRFSIAPSSLDPSNRKPLTVLNK 335 >4WUA-A nrPDB Length = 401 Score = 221 bits (563), Expect = 4e-58, Method: Composition-based stats. Identities = 84/389 (21%), Positives = 153/389 (39%), Gaps = 79/389 (20%) Query: 14 DVNTHRPREYWDYESHVVEWGN--QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK 71 D P +Y H+V+ G+ Y ++RKLG G +S V+ + +I + V +K++K Sbjct: 16 DDEQEDPNDYCKGGYHLVKIGDLFNGRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVK 75 Query: 72 PVKK--KKIKREIKILENLRG-GPN------IITLADIVK--DPVSRTPALVFEHVNNTD 120 + + EI++L+++R PN ++ L D K +VFE + + Sbjct: 76 SAEHYTETALDEIRLLKSVRNSDPNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHL 135 Query: 121 FKQL----YQTLTDYDIRFYMYEILKALDYCHSM-GIMHRDVKPHNVMI----------- 164 K + YQ L ++ + ++L+ LDY H+ I+H D+KP N+++ Sbjct: 136 LKWIIKSNYQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLA 195 Query: 165 -------------------------------------DHEHRKLRLIDWGLAEFYHPGQE 187 + E K+++ D G A + H + Sbjct: 196 AEATEWQRSGAPPPSGSAVSTAPATAGNFLVNPLEPKNAEKLKVKIADLGNACWVH--KH 253 Query: 188 YNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGH-----DNYDQL 242 + + +R ++ E+L+ Y+ D+WS CM + F + D + Sbjct: 254 FTEDIQTRQYRSLEVLIG-SGYNTPADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHI 312 Query: 243 VRIAKVLG-TEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPE----A 297 I ++LG KY+ E + D+ K W F ++ S E Sbjct: 313 ALIIELLGKVPRKLIVAGKYSKEFFTKKGDLKHITKLKPWGLFEVLVEKYEWSQEEAAGF 372 Query: 298 LDFLDKLLRYDHQSRLTAREAMEHPYFYT 326 DFL +L + R TA E + HP+ + Sbjct: 373 TDFLLPMLELIPEKRATAAECLRHPWLNS 401 >4J52-A nrPDB Length = 293 Score = 221 bits (563), Expect = 4e-58, Method: Composition-based stats. Identities = 62/292 (21%), Positives = 128/292 (43%), Gaps = 53/292 (18%) Query: 45 LGRGKYSEVFEAINITNNEKVVVKI------LKPVKKKKIKREIKILENLRGGPNIITLA 98 LG+G +++ FE + E KI LKP +++K+ EI I +L +++ Sbjct: 22 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQ-HVVGFH 80 Query: 99 DIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYCHSMGIMHR 155 +D + +V E +L++ LT+ + R+Y+ +I+ Y H ++HR Sbjct: 81 GFFED--NDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHR 138 Query: 156 DVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLD 214 D+K N+ ++ E ++++ D+GLA + + G+ V + + PE+L + + + +D Sbjct: 139 DLKLGNLFLN-EDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVL-SKKGHSFEVD 196 Query: 215 MWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILG 274 +WS+GC++ +++ K PF + ++ Y I K + Sbjct: 197 VWSIGCIMYTLLVGKPPF--------------ETSCLKETYLRIKKNEYSIPKH------ 236 Query: 275 RHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYT 326 ++P A + K+L+ D +R T E + +F + Sbjct: 237 ------------------INPVAASLIQKMLQTDPTARPTINELLNDEFFTS 270 >4B8L-A nrPDB Length = 286 Score = 221 bits (563), Expect = 4e-58, Method: Composition-based stats. Identities = 67/298 (22%), Positives = 124/298 (41%), Gaps = 53/298 (17%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK------IKREIKILENLRG 90 DD+ + R LG+GK+ V+ A N + +K+L + +K ++REI+I +LR Sbjct: 15 DDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRREIEIQSHLRH 74 Query: 91 GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYC 147 PNI+ + + D + L+ E + + Q + +M E+ AL YC Sbjct: 75 -PNILRMYNYFHD--RKRIYLMLEFAPRGELYKELQKHGRFDEQRSATFMEELADALHYC 131 Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQ 207 H ++HRD+KP N+++ ++ +L++ D+G + + P + + PE++ + + Sbjct: 132 HERKVIHRDIKPENLLMGYKG-ELKIADFGWS-VHAPSLRRRTMCGTLDYLPPEMI-EGK 188 Query: 208 MYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDP 267 +D +D+W G + + PF + + RI V Sbjct: 189 THDEKVDLWCAGVLCYEFLVGMPPF-DSPSHTETHRRIVNV------------------- 228 Query: 268 RFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFY 325 + +S + D + KLLRY RL + MEHP+ Sbjct: 229 ------------------DLKFPPFLSDGSKDLISKLLRYHPPQRLPLKGVMEHPWVK 268 >2WO6-A nrPDB Length = 382 Score = 221 bits (563), Expect = 4e-58, Method: Composition-based stats. Identities = 78/337 (23%), Positives = 151/337 (44%), Gaps = 49/337 (14%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK--KKIKREIKILENLRGGP- 92 D Y++ +G+G + +V +A + E V +KI+K K + + E+++LE + Sbjct: 53 MDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDT 112 Query: 93 ----NIITLADIVKDPVSRTPALVFEHVNNTDFKQL----YQTLTDYDIRFYMYEILKAL 144 I+ L LVFE ++ + L ++ ++ R + ++ AL Sbjct: 113 EMKYYIVHLKRHF--MFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTAL 170 Query: 145 DYCH--SMGIMHRDVKPHNVMI-DHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPE 201 + + I+H D+KP N+++ + + ++++D+G + GQ + SR+++ PE Sbjct: 171 LFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQL--GQRIYQYIQSRFYRSPE 228 Query: 202 LLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTED-------- 253 +L+ YD ++DMWSLGC+L M EP F G + DQ+ +I +VLG Sbjct: 229 VLLGM-PYDLAIDMWSLGCILVEMHTG-EPLFSGANEVDQMNKIVEVLGIPPAHILDQAP 286 Query: 254 ------------------LYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSP 295 D +Y + ++ILG + R E+ H V+ Sbjct: 287 KARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRR-AGESGHTVAD 345 Query: 296 --EALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKD 330 + D + ++L YD ++R+ A++H +F + Sbjct: 346 YLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADE 382 >6E2O-A nrPDB Length = 295 Score = 221 bits (562), Expect = 6e-58, Method: Composition-based stats. Identities = 67/335 (20%), Positives = 124/335 (37%), Gaps = 59/335 (17%) Query: 19 RPREYWDYESHVVEWGNQDDYQLVR-----KLGRGKYSEVFEAINITNNEKVVVKILKPV 73 R E D ES ++E+ DY+ LG+G Y V+ +++N ++ +K + Sbjct: 3 RSTEEGDCESDLLEY----DYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPER 58 Query: 74 KK---KKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTL-- 128 + + EI + ++L+ NI+ + + + E V L ++ Sbjct: 59 DSRYSQPLHEEIALHKHLKH-KNIVQYLGSFSE--NGFIKIFMEQVPGGSLSALLRSKWG 115 Query: 129 ----TDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHP 184 + I FY +IL+ L Y H I+HRD+K NV+I+ L++ D+G ++ Sbjct: 116 PLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAG 175 Query: 185 GQEYN-VRVASRYFKGPELL-VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQL 242 + + PE++ + Y + D+WSLGC + M K PF+ + + Sbjct: 176 INPCTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAM 235 Query: 243 VRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLD 302 ++ VH E +S EA F+ Sbjct: 236 FKVGM-----------------------------------FKVHPEIPESMSAEAKAFIL 260 Query: 303 KLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSS 337 K D R A + + + V + + Sbjct: 261 KCFEPDPDKRACANDLLVDEFLK-VSSKKKKTQPK 294 >3C51-A nrPDB Length = 543 Score = 220 bits (561), Expect = 8e-58, Method: Composition-based stats. Identities = 79/337 (23%), Positives = 128/337 (37%), Gaps = 58/337 (17%) Query: 23 YWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK------K 76 + ++ + +D + R LGRG + EVF + K L + + Sbjct: 171 FLQWKWLEAQPMGEDWFLDFRVLGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQ 230 Query: 77 KIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY-------QTLT 129 E KIL + I++LA + LV +N D + Sbjct: 231 GAMVEKKILAKV-HSRFIVSLAYAFETKTD--LCLVMTIMNGGDIRYHIYNVDEDNPGFQ 287 Query: 130 DYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ-EY 188 + FY +I+ L++ H I++RD+KP NV++D + +R+ D GLA GQ + Sbjct: 288 EPRAIFYTAQIVSGLEHLHQRNIIYRDLKPENVLLDDDG-NVRISDLGLAVELKAGQTKT 346 Query: 189 NVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKV 248 + F PELL+ + YD+S+D ++LG L MI + PF + + +V Sbjct: 347 KGYAGTPGFMAPELLLGEE-YDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKQRV 405 Query: 249 LGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYD 308 L E Y DK+ SP + DF + LL+ D Sbjct: 406 L--EQAVTYPDKF--------------------------------SPASKDFCEALLQKD 431 Query: 309 HQSRL-----TAREAMEHPYFYTVVKDQARMGSSSMP 340 + RL + HP F + Q G + P Sbjct: 432 PEKRLGFRDGSCDGLRTHPLFRDISWRQLEAGMLTPP 468 >6QAU-A nrPDB Length = 280 Score = 220 bits (560), Expect = 1e-57, Method: Composition-based stats. Identities = 60/211 (28%), Positives = 106/211 (50%), Gaps = 20/211 (9%) Query: 38 DYQLVRKLGRGKYSEVFEAINI-TNNEKVVVKILKPVKKKKIK----REIKILENLRGGP 92 +Y +G G ++ VF + + +V +K + K + +EIKIL+ L+ Sbjct: 12 EYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKILKELQH-E 70 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ---TLTDYDIRFYMYEILKALDYCHS 149 NI+ L D+ + P S LV E+ N D Q TL++ IR ++++I A+ HS Sbjct: 71 NIVALYDVQELPNS--VFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRILHS 128 Query: 150 MGIMHRDVKPHNVMIDHEHR--------KLRLIDWGLAEFYHPGQEYNVRVASRYFKGPE 201 GI+HRD+KP N+++ + +R ++++ D+G A + H S + PE Sbjct: 129 KGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAADLCGSPMYMAPE 188 Query: 202 LLVDYQMYDYSLDMWSLGCMLASMIFRKEPF 232 +++ Q YD D+WS+G ++ + K PF Sbjct: 189 VIMS-QHYDAKADLWSIGTVIYQCLVGKPPF 218 >4AF3-A nrPDB Length = 292 Score = 219 bits (559), Expect = 1e-57, Method: Composition-based stats. Identities = 70/296 (23%), Positives = 127/296 (42%), Gaps = 53/296 (17%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK------IKREIKILENLRG 90 DD+++ R LG+GK+ V+ A ++ V +K+L + +K ++REI+I +L Sbjct: 23 DDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHL-H 81 Query: 91 GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ---TLTDYDIRFYMYEILKALDYC 147 PNI+ L + D R L+ E+ + + Q T + M E+ AL YC Sbjct: 82 HPNILRLYNYFYD--RRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYC 139 Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQ 207 H ++HRD+KP N+ + +L++ D+G + + P + + PE++ + + Sbjct: 140 HGKKVIHRDIKPENL-LLGLKGELKIADFGWS-VHAPSLRRKTMCGTLDYLPPEMI-EGR 196 Query: 208 MYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDP 267 M++ +D+W +G + ++ PF N + RI KV D Sbjct: 197 MHNEKVDLWCIGVLCYELLVGNPPFESASHN-ETYRRIVKV-----------------DL 238 Query: 268 RFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323 +F + A D + KLLR++ RL + HP+ Sbjct: 239 KFPASVPTG--------------------AQDLISKLLRHNPSERLPLAQVSAHPW 274 >4FZF-B nrPDB Length = 283 Score = 218 bits (556), Expect = 3e-57, Method: Composition-based stats. Identities = 61/296 (20%), Positives = 116/296 (39%), Gaps = 49/296 (16%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK----PVKKKKIKREIKILENLRGG 91 ++ + + ++G+G + EVF+ I+ + V +KI+ + + I++EI +L Sbjct: 7 EELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSS 66 Query: 92 PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT--LTDYDIRFYMYEILKALDYCHS 149 + ++ E++ L + ++ I + EILK LDY HS Sbjct: 67 -YVTKYYGSY--LKGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHS 123 Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ-EYNVRVASRYFKGPELLVDYQM 208 +HRD+K NV++ E ++L +G+A Q + N V + ++ PE++ Sbjct: 124 EKKIHRDIKAANVLL-SEQGDVKLAAFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQ-SA 181 Query: 209 YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPR 268 YD D+WSLG + + P N ++ P Sbjct: 182 YDSKADIWSLGITAIELAKGEPP------------------------------NSDMHPM 211 Query: 269 FNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 +L + V + +F+D L D R TA+E ++H + Sbjct: 212 --RVLFLIPKNNPPTLVGD-----FTKSFKEFIDACLNKDPSFRPTAKELLKHKFI 260 >6CQF-A nrPDB Length = 297 Score = 217 bits (554), Expect = 4e-57, Method: Composition-based stats. Identities = 63/295 (21%), Positives = 121/295 (41%), Gaps = 46/295 (15%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPV---KKKKIKREIKILENLRGGP 92 +D Y L+++LG G Y EVF+A + + + V +K++K +++EI IL+ R Sbjct: 15 RDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRHA- 73 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ---TLTDYDIRFYMYEILKALDYCHS 149 NI+ + + E + +YQ +L++ I + E+L+ L Y HS Sbjct: 74 NIVAYHGSY--LWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHS 131 Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYN-VRVASRYFKGPEL--LVDY 206 +HRD+K N++I+ + ++RL D+G++ + + Y+ PE+ + Sbjct: 132 QKKIHRDIKGANILIN-DAGEVRLADFGISAQIGATLARRLAFIGTPYWMAPEVAAVALK 190 Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 266 Y+ D+WSLG + + P F H ++ + Sbjct: 191 GGYNELCDIWSLGITAIELAELQPPLFDVH---------------PLRVLFLMTKSGYQP 235 Query: 267 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEH 321 PR + + +W S +F+ L + R +A + + H Sbjct: 236 PRLKE------KGKW------------SAAFHNFIKVTLTKSPKKRPSATKMLSH 272 >4FR4-A nrPDB Length = 384 Score = 217 bits (554), Expect = 5e-57, Method: Composition-based stats. Identities = 57/322 (17%), Positives = 126/322 (39%), Gaps = 54/322 (16%) Query: 35 NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK------KKIKREIKILENL 88 N D ++++R +G+G + +V + +K + K + + +E++I++ L Sbjct: 13 NFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQGL 72 Query: 89 RGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALD 145 P ++ L +D +V + + D + Q + ++ ++ E++ ALD Sbjct: 73 EH-PFLVNLWYSFQD--EEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELVMALD 129 Query: 146 YCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVD 205 Y + I+HRD+KP N+++D EH + + D+ +A + ++ + PE+ Sbjct: 130 YLQNQRIIHRDMKPDNILLD-EHGHVHITDFNIAAMLPRETQITTMAGTKPYMAPEMFSS 188 Query: 206 YQ--MYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNI 263 + Y +++D WSLG ++ + P+ I ++++ + + Sbjct: 189 RKGAGYSFAVDWWSLGVTAYELLRGRRPY-----------HIRSSTSSKEIVHTFETTVV 237 Query: 264 ELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT-AREAMEHP 322 + S E + L KLL + R + + P Sbjct: 238 TYPSAW------------------------SQEMVSLLKKLLEPNPDQRFSQLSDVQNFP 273 Query: 323 YFYTVVKD---QARMGSSSMPG 341 Y + D Q R+ +P Sbjct: 274 YMNDINWDAVFQKRLIPGFIPN 295 >2VD5-A nrPDB Length = 412 Score = 217 bits (554), Expect = 5e-57, Method: Composition-based stats. Identities = 84/371 (22%), Positives = 132/371 (35%), Gaps = 61/371 (16%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKI------LKPVKKKKIKREIKILENLR 89 +DD+++++ +GRG +SEV + +KI LK + + E +L N Sbjct: 60 RDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVN-G 118 Query: 90 GGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTD----YDIRFYMYEILKALD 145 I L +D LV E+ D L + RFY+ EI+ A+D Sbjct: 119 DRRWITQLHFAFQD--ENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAID 176 Query: 146 YCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVR--VASRYFKGPELL 203 H +G +HRD+KP N+++D +RL D+G V + + PE+L Sbjct: 177 SVHRLGYVHRDIKPDNILLDR-CGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEIL 235 Query: 204 V------DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDY 257 Y D W+LG M + + PF+ T + Y Sbjct: 236 QAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADS--------------TAETYGK 281 Query: 258 IDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRL---T 314 I Y E V EA DF+ +LL ++RL Sbjct: 282 IVHYK-------------------EHLSLPLVDEGVPEEARDFIQRLLCP-PETRLGRGG 321 Query: 315 AREAMEHPYFYTVVKDQARMG-SSSMPGGSTPVSSANMMSGISSVPTPSPLGPLAGSPVI 373 A + HP+F+ + D R P + N + G S + Sbjct: 322 AGDFRTHPFFFGLDWDGLRDSVPPFTPDFEGATDTCNFDLVEDGLTAMVSGGGETLSDIR 381 Query: 374 AAANPLGMPVP 384 A PLG+ +P Sbjct: 382 EGA-PLGVHLP 391 >4OTD-A nrPDB Length = 341 Score = 217 bits (553), Expect = 6e-57, Method: Composition-based stats. Identities = 76/358 (21%), Positives = 138/358 (38%), Gaps = 62/358 (17%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP------VKKKKIKREIKILENL-- 88 +D++ + LGRG + +V + + E +K LK + + + E +IL + Sbjct: 12 EDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTS 71 Query: 89 RGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT--LTDYDIRFYMYEILKALDY 146 G P ++ L + P V E+ D + ++ FY ++ L + Sbjct: 72 AGHPFLVNLFGCFQTP--EHVCFVMEYSAGGDLMLHIHSDVFSEPRAIFYSACVVLGLQF 129 Query: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF-YHPGQEYNVRVASRYFKGPELLVD 205 H I++RD+K N+++D E +++ D+GL + G + + F PE+L D Sbjct: 130 LHEHKIVYRDLKLDNLLLDTEGY-VKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTD 188 Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIEL 265 Y ++D W LG +L M+ + PF G D + I Sbjct: 189 TS-YTRAVDWWGLGVLLYEMLVGESPF-PGDDEEEVFDSIVN------------------ 228 Query: 266 DPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT-----AREAME 320 R+ RF +S EA+ + +LLR + + RL A + + Sbjct: 229 -----------DEVRYPRF--------LSAEAIGIMRRLLRRNPERRLGSSERDAEDVKK 269 Query: 321 HPYFYTVVKDQA---RMGSSSMPGGSTPVSSANMMSGISSVPTPSPLGPLAGSPVIAA 375 P+F T+ + R+ +P S +N + P+ P P+ AA Sbjct: 270 QPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFDEEFTGE-APTLSPPRDARPLTAA 326 >5UUU-A nrPDB Length = 547 Score = 217 bits (552), Expect = 8e-57, Method: Composition-based stats. Identities = 73/322 (22%), Positives = 129/322 (40%), Gaps = 55/322 (17%) Query: 35 NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREI-----KILENL- 88 +D+ + R +GRG + EV+ + +K L + K + E +I+ +L Sbjct: 196 TMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLV 255 Query: 89 --RGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKA 143 P I+ ++ P + + + +N D ++ D+RFY EI+ Sbjct: 256 STGDCPFIVCMSYAFHTP--DKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILG 313 Query: 144 LDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELL 203 L++ H+ +++RD+KP N+++D EH +R+ D GLA + ++ + V + + PE+L Sbjct: 314 LEHMHNRFVVYRDLKPANILLD-EHGHVRISDLGLACDFSK-KKPHASVGTHGYMAPEVL 371 Query: 204 VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNI 263 YD S D +SLGCML ++ PF ++ + Sbjct: 372 QKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKH-----------EIDRMTLTMAV 420 Query: 264 ELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRL-----TAREA 318 EL F SPE L+ LL+ D RL A+E Sbjct: 421 ELPDSF------------------------SPELRSLLEGLLQRDVNRRLGCLGRGAQEV 456 Query: 319 MEHPYFYTVVKDQARMGSSSMP 340 E P+F ++ + P Sbjct: 457 KESPFFRSLDWQMVFLQKYPPP 478 >3PVW-A nrPDB Length = 695 Score = 216 bits (550), Expect = 2e-56, Method: Composition-based stats. Identities = 73/322 (22%), Positives = 129/322 (40%), Gaps = 55/322 (17%) Query: 35 NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREI-----KILENL- 88 +D+ + R +GRG + EV+ + +K L + K + E +I+ +L Sbjct: 187 TMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLV 246 Query: 89 --RGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKA 143 P I+ ++ P + + + +N D ++ D+RFY EI+ Sbjct: 247 STGDCPFIVCMSYAFHTP--DKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILG 304 Query: 144 LDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELL 203 L++ H+ +++RD+KP N+++D EH +R+ D GLA + ++ + V + + PE+L Sbjct: 305 LEHMHNRFVVYRDLKPANILLD-EHGHVRISDLGLACDFSK-KKPHASVGTHGYMAPEVL 362 Query: 204 VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNI 263 YD S D +SLGCML ++ PF ++ + Sbjct: 363 QKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKH-----------EIDRMTLTMAV 411 Query: 264 ELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRL-----TAREA 318 EL F SPE L+ LL+ D RL A+E Sbjct: 412 ELPDSF------------------------SPELRSLLEGLLQRDVNRRLGCLGRGAQEV 447 Query: 319 MEHPYFYTVVKDQARMGSSSMP 340 E P+F ++ + P Sbjct: 448 KESPFFRSLDWQMVFLQKYPPP 469 >2BRG-A nrPDB Length = 297 Score = 215 bits (547), Expect = 3e-56, Method: Composition-based stats. Identities = 69/321 (21%), Positives = 130/321 (40%), Gaps = 49/321 (15%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK----KKIKREIKILENLRGGP 92 +D+ LV+ LG G Y EV A+N E V VKI+ + + IK+EI I + L Sbjct: 7 EDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKML-NHE 65 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYCHS 149 N++ L E+ + + + + + D + + ++++ + Y H Sbjct: 66 NVVKFYG--HRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHG 123 Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE---YNVRVASRYFKGPELLVDY 206 +GI HRD+KP N+++D E L++ D+GLA + N + + PELL Sbjct: 124 IGITHRDIKPENLLLD-ERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRR 182 Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 266 + + +D+WS G +L +M+ + P+ D+ ++ D+ +K Sbjct: 183 EFHAEPVDVWSCGIVLTAMLAGELPWDQPSDS------------CQEYSDWKEKKTYLNP 230 Query: 267 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYT 326 + D L K+L + +R+T + + ++ Sbjct: 231 WKKIDSAPLA-----------------------LLHKILVENPSARITIPDIKKDRWYNK 267 Query: 327 VVKDQARMGSSSMPGGSTPVS 347 +K A+ + G S S Sbjct: 268 PLKKGAKRPRVTSGGVSESPS 288 >3ALO-A nrPDB Length = 327 Score = 213 bits (543), Expect = 9e-56, Method: Composition-based stats. Identities = 59/335 (17%), Positives = 130/335 (38%), Gaps = 60/335 (17%) Query: 17 THRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPV--- 73 P ++WD+ + +D + + ++GRG Y V + ++ + + + VK ++ Sbjct: 10 KISPEQHWDFTA--------EDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDE 61 Query: 74 -KKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ------ 126 ++K++ ++ ++ P I+ + + E ++ T F + Y+ Sbjct: 62 KEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDC--WICMELMS-TSFDKFYKYVYSVL 118 Query: 127 --TLTDYDIRFYMYEILKALDYCHSM-GIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH 183 + + + +KAL++ I+HRD+KP N+++D ++L D+G++ Sbjct: 119 DDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSG-NIKLCDFGISGQLV 177 Query: 184 PGQEYNVRVASRYFKGPELL---VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYD 240 R + PE + Q YD D+WSLG L + + P+ + +D Sbjct: 178 DSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFD 237 Query: 241 QLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDF 300 QL ++ K G + + + SP ++F Sbjct: 238 QLTQVVK--GDPPQ------------------------------LSNSEEREFSPSFINF 265 Query: 301 LDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMG 335 ++ L D R +E ++HP+ + + Sbjct: 266 VNLCLTKDESKRPKYKELLKHPFILMYEERAVEVA 300 >6CCF-A nrPDB Length = 290 Score = 213 bits (542), Expect = 1e-55, Method: Composition-based stats. Identities = 61/323 (18%), Positives = 124/323 (38%), Gaps = 76/323 (23%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVV----------------------------- 67 + Y+L ++G+G Y V A N + + + Sbjct: 5 NQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGG 64 Query: 68 --KILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQ-- 123 K L P+ +++ +EI IL+ L N++ L +++ DP LVF+ + + Sbjct: 65 PAKQLLPL--ERVYQEIAILKKL-DHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEVP 121 Query: 124 LYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH 183 + ++ R Y+ +++ L+Y H I+HRD+KP N+++ + +++ D+G++ + Sbjct: 122 CDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGH-VKIADFGVSNQFE 180 Query: 184 -PGQEYNVRVASRYFKGPELLVDYQ--MYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYD 240 + + + F PE + D +LD+W+ G L ++ K PF Sbjct: 181 GNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFID------ 234 Query: 241 QLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDF 300 D + RK V + +S E D Sbjct: 235 ------------------------------DFILALHRKIKNEPVVFPEEPEISEELKDL 264 Query: 301 LDKLLRYDHQSRLTAREAMEHPY 323 + K+L + ++R+ + HP+ Sbjct: 265 ILKMLDKNPETRIGVPDIKLHPW 287 >4APC-A nrPDB Length = 350 Score = 212 bits (540), Expect = 2e-55, Method: Composition-based stats. Identities = 57/292 (19%), Positives = 127/292 (43%), Gaps = 28/292 (9%) Query: 25 DYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVK-----ILKPVKKKKIK 79 D + + + + + Y ++K+G G + + + + + V+K + ++++ + Sbjct: 12 DLGTENLYFQSMEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESR 71 Query: 80 REIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT-----LTDYDIR 134 RE+ +L N++ PNI+ + ++ S +V ++ D + + I Sbjct: 72 REVAVLANMKH-PNIVQYRESFEENGS--LYIVMDYCEGGDLFKRINAQKGVLFQEDQIL 128 Query: 135 FYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEY-NVRVA 193 + +I AL + H I+HRD+K N+ + + ++L D+G+A + E + Sbjct: 129 DWFVQICLALKHVHDRKILHRDIKSQNIFLTKDG-TVQLGDFGIARVLNSTVELARACIG 187 Query: 194 SRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTED 253 + Y+ PE + + + Y+ D+W+LGC+L + K F G L I+ Sbjct: 188 TPYYLSPE-ICENKPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVS 246 Query: 254 LYDYIDKYNIELDPRFNDILGRHSRKRW-------ERFVHSENQHLVSPEAL 298 L+ Y+ +L + + R+ R R + F+ + +SP+ + Sbjct: 247 LH-----YSYDLRSLVSQLFKRNPRDRPSVNSILEKGFIAKRIEKFLSPQLI 293 >2JD5-A nrPDB Length = 373 Score = 212 bits (539), Expect = 2e-55, Method: Composition-based stats. Identities = 90/346 (26%), Positives = 148/346 (42%), Gaps = 45/346 (13%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK--PVKKKKIKREIKILENLRGGPN-- 93 Y LVRKLG G +S V+ A ++ NN V +KI++ V + + EIK+L+ + N Sbjct: 20 RYILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVRGDKVYTEAAEDEIKLLQRVNDADNTK 79 Query: 94 --------IITLADIV--KDPVSRTPALVFEHVNNTDF----KQLYQTLTDYDIRFYMYE 139 I+ L D K P +VFE + K ++ + ++ + Sbjct: 80 EDSMGANHILKLLDHFNHKGPNGVHVVMVFEVLGENLLALIKKYEHRGIPLIYVKQISKQ 139 Query: 140 ILKALDYCHSM-GIMHRDVKPHNVMIDHEHR-----KLRLIDWGLAEFYHPGQEYNVRVA 193 +L LDY H GI+H D+KP NV+++ ++++ D G A +Y + Y + Sbjct: 140 LLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNACWY--DEHYTNSIQ 197 Query: 194 SRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFH--GHD---NYDQLVRIAKV 248 +R ++ PE+L+ + D+WS C++ +I F GH + D + +I ++ Sbjct: 198 TREYRSPEVLLGA-PWGCGADIWSTACLIFELITGDFLFEPDEGHSYTKDDDHIAQIIEL 256 Query: 249 LGTEDLYDY-IDKYNIELDPRFNDILGRHSRKRWE-RFVHSENQHLVSPEAL---DFLDK 303 LG Y KY + K W V +E EA DFL Sbjct: 257 LGELPSYLLRNGKYTRTFFNSRGLLRNISKLKFWPLEDVLTEKYKFSKDEAKEISDFLSP 316 Query: 304 LLRYDHQSRLTAREAMEHPYFYTV-------VKDQARMGSSS-MPG 341 +L+ D + R A + HP+ V D+ GS S +PG Sbjct: 317 MLQLDPRKRADAGGLVNHPWLKDTLGMEEIRVPDRELYGSGSDIPG 362 >3FME-A nrPDB Length = 290 Score = 211 bits (538), Expect = 3e-55, Method: Composition-based stats. Identities = 61/303 (20%), Positives = 127/303 (41%), Gaps = 54/303 (17%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK----PVKKKKIKREIKILENLRGGP 92 DD + + +LGRG Y V + ++ + + + VK ++ ++K++ ++ I P Sbjct: 7 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCP 66 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNTDFKQLY-------QTLTDYDIRFYMYEILKALD 145 +T + + E ++ T + Y QT+ + + I+KAL+ Sbjct: 67 FTVTFYGALFREGD--VWICMELMD-TSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALE 123 Query: 146 YCHSM-GIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELL- 203 + HS ++HRDVKP NV+I+ ++++ D+G++ + ++ + + PE + Sbjct: 124 HLHSKLSVIHRDVKPSNVLINA-LGQVKMCDFGISGYLVDDVAKDIDAGCKPYMAPERIN 182 Query: 204 --VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKY 261 ++ + Y D+WSLG + + + P+ + QL ++ + Sbjct: 183 PELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVE-------------- 228 Query: 262 NIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEH 321 E P+ S E +DF + L+ + + R T E M+H Sbjct: 229 --EPSPQLP-------------------ADKFSAEFVDFTSQCLKKNSKERPTYPELMQH 267 Query: 322 PYF 324 P+F Sbjct: 268 PFF 270 >4CSV-A nrPDB Length = 275 Score = 211 bits (538), Expect = 4e-55, Method: Composition-based stats. Identities = 53/275 (19%), Positives = 118/275 (42%), Gaps = 34/275 (12%) Query: 20 PREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK--PVKKKK 77 P + W+ + + L RKLG G++ EV+E N +V VK LK + ++ Sbjct: 2 PHDKWEIP--------RSEITLERKLGSGQFGEVYEGKWRNYNIEVAVKTLKEGTMSVEE 53 Query: 78 IKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ-----TLTDYD 132 +E +I++ L+ PN++ L + ++ E++++ + T+ Sbjct: 54 FLQEAQIMKKLKH-PNLVQLYGVCTKEP--PIYIITEYMSHGSLLDYLRDCEGHTVNAQA 110 Query: 133 IRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRV 192 + ++ + Y S +HRD+ N ++ E+ +++ D+GLA + EY R Sbjct: 111 LLDMAAQVASGMAYLESQNFIHRDLAARNCLVG-ENNVVKVADFGLARLINED-EYTARA 168 Query: 193 ASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVL 249 +++ + PE + Y + D+W+ G +L + + + G + + ++ + Sbjct: 169 GAKFPIKWTAPEAI-SYNRFSIKSDVWAFGILLWEIFTYGQVPYPGMSGSEVIEQVERGY 227 Query: 250 -------GTEDLYDYIDKY---NIELDPRFNDILG 274 E++Y+ + + + E P F + L Sbjct: 228 RMPRPQGCPEEIYELMLQCWNKSPEERPTFAETLH 262 >6BXI-A nrPDB Length = 333 Score = 211 bits (537), Expect = 4e-55, Method: Composition-based stats. Identities = 69/372 (18%), Positives = 136/372 (36%), Gaps = 93/372 (25%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPV---KKKK---IKREIKILENLRG 90 +D++ ++ +GRG + EV +KIL+ +K++ I+ E IL Sbjct: 6 EDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVE-AD 64 Query: 91 GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYC 147 ++ + +D + L+ E + D L TLT+ + +FY+ E + A+D Sbjct: 65 SLWVVKMFYSFQDKL--NLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSI 122 Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA---EFYHPGQEYN--------------- 189 H +G +HRD+KP N+++D + ++L D+GL + H + Y Sbjct: 123 HQLGFIHRDIKPDNLLLDSKGH-VKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNM 181 Query: 190 ------------------VRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEP 231 V + + PE+ + Y+ D WSLG ++ M+ P Sbjct: 182 NSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQT-GYNKLCDWWSLGVIMYEMLIGYPP 240 Query: 232 FFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQH 291 F + ++ W+ + + Sbjct: 241 FCS-ETPQETYKKVMN---------------------------------WKETLTFPPEV 266 Query: 292 LVSPEALDFLDK-LLRYDHQSRLTA---REAMEHPYFYTVVKDQARMGSSSMPGGSTPVS 347 +S +A D + + ++H R+ A E + +F V + R +++ S + Sbjct: 267 PISEKAKDLILRFCCEWEH--RIGAPGVEEIKSNSFFEGVDWEHIRERPAAI---SIEIK 321 Query: 348 SANMMSGISSVP 359 S + S P Sbjct: 322 SIDDTSNFDEFP 333 >5TQX-A nrPDB Length = 655 Score = 211 bits (537), Expect = 5e-55, Method: Composition-based stats. Identities = 65/296 (21%), Positives = 122/296 (41%), Gaps = 31/296 (10%) Query: 32 EWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKI----LKPVKKKKIKREIKILEN 87 E+G +++ +LG G + V + + K+ +K L +++ EI+I++ Sbjct: 3 EFGAGGPWEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCHEIQIMKK 62 Query: 88 LRGGPNIITLADIVKDP---VSRTPALVFEHVNNTDFKQLYQT------LTDYDIRFYMY 138 L N++ D+ ++ + P L E+ + D ++L L + I + Sbjct: 63 LNHA-NVVKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLS 121 Query: 139 EILKALDYCHSMGIMHRDVKPHNVMIDHEHRKL--RLIDWGLAEFYHPGQEYNVRVASRY 196 +I + Y H I+HRD+KP N+++ K+ ++ID G A+ G+ V + Sbjct: 122 DIGSGIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGELCTEFVGTLQ 181 Query: 197 FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYD 256 + PE L + + Y ++D WS G M+ I PF H + +I K +D Sbjct: 182 YLAPE-LFENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKK----KDPKC 236 Query: 257 YIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSR 312 + + RF+ L + + EN L +L +D Q R Sbjct: 237 IFACEEMSGEVRFSSHLPQPNSLCSLIVEPMENW----------LQLMLNWDPQQR 282 >1U5R-A nrPDB Length = 348 Score = 211 bits (537), Expect = 5e-55, Method: Composition-based stats. Identities = 70/296 (23%), Positives = 123/296 (41%), Gaps = 54/296 (18%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILK------PVKKKKIKREIKILENLRGGP 92 + +R++G G + V+ A ++ N+E V +K + K + I +E++ L+ LR P Sbjct: 56 FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRH-P 114 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNT--DFKQLYQT-LTDYDIRFYMYEILKALDYCHS 149 N I T LV E+ + D ++++ L + +I + L+ L Y HS Sbjct: 115 NTIQYRGCYLR--EHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHS 172 Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELL--VDYQ 207 ++HRDVK N+++ E ++L D+G A P N V + Y+ PE++ +D Sbjct: 173 HNMIHRDVKAGNILL-SEPGLVKLGDFGSASIMAPA---NSFVGTPYWMAPEVILAMDEG 228 Query: 208 MYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDP 267 YD +D+WSLG + RK P F+ + L IA+ Sbjct: 229 QYDGKVDVWSLGITCIELAERKPPLFN-MNAMSALYHIAQ-------------------- 267 Query: 268 RFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323 + S +F+D L+ Q R T+ ++H + Sbjct: 268 ---------------NESPALQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRF 308 >2GCD-A nrPDB Length = 309 Score = 210 bits (535), Expect = 7e-55, Method: Composition-based stats. Identities = 70/296 (23%), Positives = 123/296 (41%), Gaps = 54/296 (18%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILK------PVKKKKIKREIKILENLRGGP 92 + +R++G G + V+ A ++ N+E V +K + K + I +E++ L+ LR P Sbjct: 17 FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRH-P 75 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNT--DFKQLYQT-LTDYDIRFYMYEILKALDYCHS 149 N I T LV E+ + D ++++ L + +I + L+ L Y HS Sbjct: 76 NTIQYRGCY--LREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHS 133 Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELL--VDYQ 207 ++HRDVK N+++ E ++L D+G A P N V + Y+ PE++ +D Sbjct: 134 HNMIHRDVKAGNILL-SEPGLVKLGDFGSASIMAPA---NSFVGTPYWMAPEVILAMDEG 189 Query: 208 MYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDP 267 YD +D+WSLG + RK P F+ + L IA+ Sbjct: 190 QYDGKVDVWSLGITCIELAERKPPLFN-MNAMSALYHIAQ-------------------- 228 Query: 268 RFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323 + S +F+D L+ Q R T+ ++H + Sbjct: 229 ---------------NESPALQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRF 269 >3M42-A nrPDB Length = 299 Score = 209 bits (532), Expect = 2e-54, Method: Composition-based stats. Identities = 71/328 (21%), Positives = 127/328 (38%), Gaps = 75/328 (22%) Query: 37 DDYQLV-RKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNII 95 DDY++ + LG G +V + N EK +K+L K +RE+++ P+I+ Sbjct: 17 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML--QDCPKARREVELHWRASQCPHIV 74 Query: 96 TLADIVKD--PVSRTPALVFEHVNNTDFKQLYQ-----TLTDYDIRFYMYEILKALDYCH 148 + D+ ++ + +V E ++ + Q T+ + M I +A+ Y H Sbjct: 75 RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 134 Query: 149 SMGIMHRDVKPHNVMIDHE--HRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDY 206 S+ I HRDVKP N++ + + L+L D+G A+ Sbjct: 135 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKET----------------------TG 172 Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 266 + YD S DMWSLG ++ ++ PF+ H + + + I E Sbjct: 173 EKYDKSCDMWSLGVIMYILLCGYPPFYSNH----------GLAISPGMKTRIRMGQYEFP 222 Query: 267 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYT 326 + VS E + LL+ + R+T E M HP+ Sbjct: 223 --------------------NPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI-- 260 Query: 327 VVKDQARMGSSSMPGGSTPVSSANMMSG 354 M S+ +P TP+ ++ ++ Sbjct: 261 -------MQSTKVP--QTPLHTSRVLKE 279 >4OLI-A nrPDB Length = 645 Score = 209 bits (532), Expect = 2e-54, Method: Composition-based stats. Identities = 68/301 (22%), Positives = 128/301 (42%), Gaps = 26/301 (8%) Query: 6 PSRARVYTDVNTHRPREYWDYESHVVEWGNQD------DY-QLVRKLGRGKYSEV----F 54 PS + D+ +P D + + D Y + +R LG G + +V + Sbjct: 315 PSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCY 374 Query: 55 EAINITNNEKVVVKILK----PVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPA 110 + N E V VK LK P + K+EI IL L +II +D ++ Sbjct: 375 DPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYH-EHIIKYKGCCEDQGEKSLQ 433 Query: 111 LVFEHVNNTDFKQLY--QTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEH 168 LV E+V + ++ + + +I + + Y HS +HR++ NV++D++ Sbjct: 434 LVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHSQHYIHRNLAARNVLLDND- 492 Query: 169 RKLRLIDWGLAEFYHPGQEYN----VRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLAS 224 R +++ D+GLA+ G EY + ++ PE L +Y+ Y Y+ D+WS G L Sbjct: 493 RLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFY-YASDVWSFGVTLYE 551 Query: 225 MIFRKEPFFHGHDNYDQLVRIAK-VLGTEDLYDYIDKYNIELDP-RFNDILGRHSRKRWE 282 ++ + + +L+ IA+ + L + +++ P + + + WE Sbjct: 552 LLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWE 611 Query: 283 R 283 Sbjct: 612 T 612 Score = 83.5 bits (205), Expect = 1e-16, Method: Composition-based stats. Identities = 37/299 (12%), Positives = 84/299 (28%), Gaps = 69/299 (23%) Query: 56 AINITNNEKVVVKILKPVKKK---KIKREIKILENLRGGPNIITLADIVKDPVSRTPALV 112 + +VV+K+L P ++ + ++ + + +V Sbjct: 88 GRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHT-HLAFVHGVCVRGPENI--MV 144 Query: 113 FEHVNNTDFKQLYQT----LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEH 168 E+V + + + ++ AL Y + ++H +V N+++ Sbjct: 145 TEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLG 204 Query: 169 RK------LRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDY-QMYDYSLDMWSLGCM 221 ++L D G+ +E R+ + PE L ++D W G Sbjct: 205 LAEGTSPFIKLSDPGVGLGALSREERVERI---PWLAPECLPGGANSLSTAMDKWGFGAT 261 Query: 222 LASMIF-RKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKR 280 L + F + P + + F R Sbjct: 262 LLEICFDGEAP--------------------------LQSRSPSEKEHFYQRQHRLPEPS 295 Query: 281 WERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSM 339 + + L Y+ R + F T+++D R+ ++ Sbjct: 296 CPQLAT-------------LTSQCLTYEPTQRPS---------FRTILRDLTRLQPHNL 332 >4F9B-A nrPDB Length = 361 Score = 209 bits (531), Expect = 2e-54, Method: Composition-based stats. Identities = 82/340 (24%), Positives = 144/340 (42%), Gaps = 54/340 (15%) Query: 39 YQLVRKLGRGKYSEVFEAI---NITNNEKVVVKILKPVKKK-KIKREIKILENLRGGPNI 94 +++ K+G G +S V+ A + EK+ +K L P +I E++ L G N+ Sbjct: 23 FKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQCLTVAGGQDNV 82 Query: 95 ITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMH 154 + + + + + ++ + F + +L+ ++R YM + KAL H GI+H Sbjct: 83 MGVKYCFR--KNDHVVIAMPYLEHESFLDILNSLSFQEVREYMLNLFKALKRIHQFGIVH 140 Query: 155 RDVKPHNVMIDHEHRKLRLIDWGLAEFYHPG----------------------------- 185 RDVKP N + + +K L+D+GLA+ H Sbjct: 141 RDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNKCSICLSRR 200 Query: 186 QEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRI 245 Q+ R + F+ PE+L ++DMWS G + S++ + PF+ D+ L +I Sbjct: 201 QQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDDLTALAQI 260 Query: 246 AKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERF------------------VHS 287 + G+ + + + ++ + RK ER + Sbjct: 261 MTIRGSRETIQAAKTFGKSILCS-KEVPAQDLRKLCERLRGMDSSTPKLTSDIQGHATNL 319 Query: 288 ENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTV 327 E + V EA D LDKLL + SR+TA EA+ HP+F + Sbjct: 320 EGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFFKDM 359 >4CRS-A nrPDB Length = 341 Score = 209 bits (531), Expect = 2e-54, Method: Composition-based stats. Identities = 73/356 (20%), Positives = 128/356 (35%), Gaps = 67/356 (18%) Query: 35 NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP------VKKKKIKREIKILENL 88 N D++ L RG + +V A NE +K LK + + E +I E + Sbjct: 10 NLQDFRCCAVLLRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETV 69 Query: 89 RG--GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT--LTDYDIRFYMYEILKAL 144 P ++ L + V E+ D T ++ FY ++ L Sbjct: 70 NSVRHPFLVNLFACFQ--TKEHVCFVMEYAAGGDLMMHIHTDVFSEPRAVFYAACVVLGL 127 Query: 145 DYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF-YHPGQEYNVRVASRYFKGPELL 203 Y H I++RD+K N+++D E +++ D+GL + G + + F PE+L Sbjct: 128 QYLHEHKIVYRDLKLDNLLLDTEGF-VKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVL 186 Query: 204 VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNI 263 + Y ++D W LG ++ M+ + PF G D + I Sbjct: 187 TETS-YTRAVDWWGLGVLIYEMLVGESPF-PGDDEEEVFDSIVN---------------- 228 Query: 264 ELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTARE-----A 318 R+ RF +S EA+ + +LLR + + RL A E Sbjct: 229 -------------DEVRYPRF--------LSTEAISIMRRLLRRNPERRLGASEKDAEDV 267 Query: 319 MEHPYFYTVVKD---QARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLGPLAGSP 371 +HP+F + ++ +P +N +S P+ P Sbjct: 268 KKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNFDDEFTSE------APILTPP 317 >4KIK-B nrPDB Length = 677 Score = 208 bits (530), Expect = 3e-54, Method: Composition-based stats. Identities = 64/298 (21%), Positives = 117/298 (39%), Gaps = 44/298 (14%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKI----LKPVKKKKIKREIKILENLRGGPNI 94 +++ +LG G + V N E++ +K L P +++ EI+I+ L PN+ Sbjct: 21 WEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQIMRRLTH-PNV 79 Query: 95 ITLADIVKDP----VSRTPALVFEHVNNTDFKQLYQTLT------DYDIRFYMYEILKAL 144 + D+ + + P L E+ D ++ + I + +I AL Sbjct: 80 VAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASAL 139 Query: 145 DYCHSMGIMHRDVKPHNVMIDHEHRKL--RLIDWGLAEFYHPGQEYNVRVASRYFKGPEL 202 Y H I+HRD+KP N+++ ++L ++ID G A+ G V + + PEL Sbjct: 140 RYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPEL 199 Query: 203 LVDYQMYDYSLDMWSLGCMLASMIFRKEPFFH------GHDNYDQLVRIAKVLGTEDLYD 256 L + Q Y ++D WS G + I PF H Q + ++ +EDL Sbjct: 200 L-EQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEV-DIVVSEDLNG 257 Query: 257 YIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT 314 + + P + + ++W L +L + + R T Sbjct: 258 TVKFSSSLPYPNNLNSVLAERLEKW-------------------LQLMLMWHPRQRGT 296 >4YHJ-A nrPDB Length = 584 Score = 208 bits (530), Expect = 3e-54, Method: Composition-based stats. Identities = 68/340 (20%), Positives = 123/340 (36%), Gaps = 55/340 (16%) Query: 22 EYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK------K 75 ++ ++ + ++ ++ R LG+G + EV + K L+ + + Sbjct: 170 QFLQWKWLERQPVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGE 229 Query: 76 KKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY-----QTLTD 130 E +ILE ++ +++LA + LV +N D K + Sbjct: 230 AMALNEKRILEKVQ-SRFVVSLAYAYE--TKDALCLVLTIMNGGDLKFHIYNLGNPGFDE 286 Query: 131 YDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNV 190 FY E+ L+ I++RD+KP N+++D + +R+ D GLA GQ Sbjct: 287 QRAVFYAAELCCGLEDLQRERIVYRDLKPENILLD-DRGHIRISDLGLATEIPEGQRVRG 345 Query: 191 RVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLG 250 RV + + PE++ + + Y +S D W LGC++ MI PF + + + Sbjct: 346 RVGTVGYMAPEVV-NNEKYTFSPDWWGLGCLIYEMIQGHSPF----------KKYKEKVK 394 Query: 251 TEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQ 310 E++ I E +F S +A LL + Sbjct: 395 WEEVDQRIKNDTEEYSEKF------------------------SEDAKSICRMLLTKNPS 430 Query: 311 SRL-----TAREAMEHPYFYTVVKDQARMGSSSMPGGSTP 345 RL A +HP F + + P P Sbjct: 431 KRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDP 470 >6DBM-A nrPDB Length = 318 Score = 206 bits (525), Expect = 1e-53, Method: Composition-based stats. Identities = 62/261 (23%), Positives = 116/261 (44%), Gaps = 19/261 (7%) Query: 39 YQLVRKLGRGKYSEV----FEAINITNNEKVVVKILK----PVKKKKIKREIKILENLRG 90 + +R LG G + +V ++ N E V VK LK P + K+EI IL L Sbjct: 33 LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAGPQHRSGWKQEIDILRTLYH 92 Query: 91 GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY--QTLTDYDIRFYMYEILKALDYCH 148 +II +D + + LV E+V + ++ + + +I + + Y H Sbjct: 93 -EHIIKYKGCCEDAGAASLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLH 151 Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYN----VRVASRYFKGPELLV 204 S +HRD+ NV++D++ R +++ D+GLA+ G EY + ++ PE L Sbjct: 152 SQHYIHRDLAARNVLLDND-RLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLK 210 Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAK-VLGTEDLYDYIDKYNI 263 +Y+ Y Y+ D+WS G L ++ + + +L+ IA+ + L + +++ Sbjct: 211 EYKFY-YASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGER 269 Query: 264 ELDP-RFNDILGRHSRKRWER 283 P + + + WE Sbjct: 270 LPRPDKCPAEVYHLMKNCWET 290 >3EQC-A nrPDB Length = 360 Score = 206 bits (525), Expect = 1e-53, Method: Composition-based stats. Identities = 65/333 (19%), Positives = 128/333 (38%), Gaps = 26/333 (7%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKI----LKPVKKKKIKREIKILENLRGGP 92 DD++ + +LG G VF+ + + + K+ +KP + +I RE+++L P Sbjct: 33 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHEC-NSP 91 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYC-H 148 I+ ++ EH++ Q+ + + + + ++K L Y Sbjct: 92 YIVGFYGAFYS--DGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLRE 149 Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQM 208 IMHRDVKP N++++ +++L D+G++ N V +R + PE L Sbjct: 150 KHKIMHRDVKPSNILVNSRG-EIKLCDFGVSGQLIDSMA-NSFVGTRSYMSPERLQGT-H 206 Query: 209 YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLG--------TEDLYDYIDK 260 Y D+WS+G L M + P +L+ +V G ++K Sbjct: 207 YSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLNK 266 Query: 261 YNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAME 320 + ++ P + + S E DF++K L + R ++ M Sbjct: 267 FGMDSRP--PMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMV 324 Query: 321 HPYFYTVVKDQARMGSS--SMPGGSTPVSSANM 351 H + ++ S G + P + + Sbjct: 325 HAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHA 357 >3QA8-A nrPDB Length = 676 Score = 206 bits (525), Expect = 1e-53, Method: Composition-based stats. Identities = 55/212 (25%), Positives = 99/212 (46%), Gaps = 18/212 (8%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKI----LKPVKKKKIKREIKILENLRGGPNI 94 +++ +LG G + V I+ E+V +K L P +++ EI+I++ L PN+ Sbjct: 16 WEMKERLGTGGFGYVLRWIHQDTGEQVAIKQCRQELSPKNRERWCLEIQIMKKL-NHPNV 74 Query: 95 ITLADI----VKDPVSRTPALVFEHVNNTDFKQLYQT------LTDYDIRFYMYEILKAL 144 ++ ++ K + P L E+ D ++ L + IR + +I AL Sbjct: 75 VSAREVPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGPIRTLLSDISSAL 134 Query: 145 DYCHSMGIMHRDVKPHNVMIDHEHRKL--RLIDWGLAEFYHPGQEYNVRVASRYFKGPEL 202 Y H I+HRD+KP N+++ ++L ++ID G A+ G+ V + + PEL Sbjct: 135 RYLHENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQGELCTEFVGTLQYLAPEL 194 Query: 203 LVDYQMYDYSLDMWSLGCMLASMIFRKEPFFH 234 L + + Y ++D WS G + I PF Sbjct: 195 L-EQKKYTVTVDYWSFGTLAFECITGFRPFLP 225 >5KKR-C nrPDB Length = 395 Score = 206 bits (525), Expect = 1e-53, Method: Composition-based stats. Identities = 65/331 (19%), Positives = 126/331 (38%), Gaps = 22/331 (6%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKI----LKPVKKKKIKREIKILENLRGGP 92 DD++ + +LG G VF+ + + + K+ +KP + +I RE+++L P Sbjct: 68 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHEC-NSP 126 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYC-H 148 I+ ++ EH++ Q+ + + + + ++K L Y Sbjct: 127 YIVGFYGAFYS--DGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLRE 184 Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQM 208 IMHRDVKP N++++ +++L D+G++ N V +R + PE L Sbjct: 185 KHKIMHRDVKPSNILVNSRG-EIKLCDFGVSGQLIDSMA-NSFVGTRSYMSPERLQGT-H 241 Query: 209 YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKY------N 262 Y D+WS+G L M + P +L+ +V G + + Sbjct: 242 YSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSS 301 Query: 263 IELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHP 322 +D R + + S E DF++K L + R ++ M H Sbjct: 302 YGMDSRPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFVNKCLIKNPAERADLKQLMVHA 361 Query: 323 YFYTVVKDQARMGSS--SMPGGSTPVSSANM 351 + ++ S G + P + + Sbjct: 362 FIKRSDAEEVDFAGWLCSTIGLNQPSTPTHA 392 >2XNP-A nrPDB Length = 279 Score = 206 bits (524), Expect = 1e-53, Method: Composition-based stats. Identities = 66/306 (21%), Positives = 123/306 (40%), Gaps = 58/306 (18%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK-----PVKKKKIKREIKILENLRGG 91 +DY+++ +G G Y + ++ + +V K L +K+ + E+ +L L+ Sbjct: 6 EDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKH- 64 Query: 92 PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY-------QTLTDYDIRFYMYEILKAL 144 PNI+ D + D + T +V E+ D + Q L + + M ++ AL Sbjct: 65 PNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLAL 124 Query: 145 DYCHSMG-----IMHRDVKPHNVMIDHEHRKLRLIDWGLAEFY-HPGQEYNVRVASRYFK 198 CH ++HRD+KP NV +D + + ++L D+GLA H V + Y+ Sbjct: 125 KECHRRSDGGHTVLHRDLKPANVFLDGK-QNVKLGDFGLARILNHDTSFAKTFVGTPYYM 183 Query: 199 GPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYI 258 PE + + Y+ D+WSLGC+L + PF + Q Sbjct: 184 SPEQM-NRMSYNEKSDIWSLGCLLYELCALMPPF----TAFSQ----------------- 221 Query: 259 DKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREA 318 ++ G+ ++ R + S E + + ++L R + E Sbjct: 222 -----------KELAGKIREGKFRRIP-----YRYSDELNEIITRMLNLKDYHRPSVEEI 265 Query: 319 MEHPYF 324 +E+P Sbjct: 266 LENPLI 271 >2WQN-A nrPDB Length = 310 Score = 206 bits (523), Expect = 2e-53, Method: Composition-based stats. Identities = 64/259 (24%), Positives = 115/259 (44%), Gaps = 21/259 (8%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKI------LKPVKKKKIKREIKILENLRGG 91 ++++ +K+GRG++SEV+ A + + V +K + + +EI +L+ L Sbjct: 33 NFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQL-NH 91 Query: 92 PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTL-------TDYDIRFYMYEILKAL 144 PN+I + +V E + D ++ + + + Y ++ AL Sbjct: 92 PNVIKYYASFIE--DNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSAL 149 Query: 145 DYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHP-GQEYNVRVASRYFKGPELL 203 ++ HS +MHRD+KP NV I ++L D GL F+ + V + Y+ PE + Sbjct: 150 EHMHSRRVMHRDIKPANVFITATG-VVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERI 208 Query: 204 VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNI 263 + Y++ D+WSLGC+L M + PF+ N L + + L D Y+ Sbjct: 209 HE-NGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPS--DHYSE 265 Query: 264 ELDPRFNDILGRHSRKRWE 282 EL N + KR + Sbjct: 266 ELRQLVNMCINPDPEKRPD 284 >4E20-A nrPDB Length = 290 Score = 204 bits (519), Expect = 5e-53, Method: Composition-based stats. Identities = 53/219 (24%), Positives = 100/219 (45%), Gaps = 17/219 (7%) Query: 39 YQLVRKLGRGKYSEV----FEAINITNNEKVVVKILK----PVKKKKIKREIKILENLRG 90 + +R LG G + +V ++ N E V VK LK P + +REI+IL L Sbjct: 10 LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSGWQREIEILRTLYH 69 Query: 91 GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY--QTLTDYDIRFYMYEILKALDYCH 148 +I+ +D ++ LV E+V + + + + +I + + Y H Sbjct: 70 -EHIVKYKGCCEDQGEKSVQLVMEYVPLGSLRDYLPRHCVGLAQLLLFAQQICEGMAYLH 128 Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYN----VRVASRYFKGPELLV 204 + +HR + NV++D++ R +++ D+GLA+ G EY + ++ PE L Sbjct: 129 AQHYIHRALAARNVLLDND-RLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLK 187 Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLV 243 + + Y Y+ D+WS G L ++ + H + +L+ Sbjct: 188 ECKFY-YASDVWSFGVTLYELLTYCDSNQSPHTKFTELI 225 >4PWN-A nrPDB Length = 274 Score = 203 bits (516), Expect = 1e-52, Method: Composition-based stats. Identities = 53/295 (17%), Positives = 111/295 (37%), Gaps = 50/295 (16%) Query: 44 KLGRGKYSEVFEAINITNNEKVVV-----KILKPVKKKKIKREIKILENLRGGPNIITLA 98 ++GRG + V++ ++ +V + L ++++ K E ++L+ L+ PNI+ Sbjct: 17 EIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQH-PNIVRFY 75 Query: 99 DIVKD--PVSRTPALVFEHVNNTDFKQLYQTLTDYDI---RFYMYEILKALDYCHSMG-- 151 D + + LV E + + K + I R + +ILK L + H+ Sbjct: 76 DSWESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKGLQFLHTRTPP 135 Query: 152 IMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDY 211 I+HRD+K N+ I +++ D GLA + + F PE+ + YD Sbjct: 136 IIHRDLKCDNIFITGPTGSVKIGDLGLATLEKRASFAKSVIGTPEFMAPEMYEE--KYDE 193 Query: 212 SLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFND 271 S+D+++ G + M + P+ + R+ Sbjct: 194 SVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVT------------------------- 228 Query: 272 ILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYT 326 + + PE + ++ +R + R + ++ + H +F Sbjct: 229 ----------SGVKPASFDKVAIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQE 273 >5O2C-A nrPDB Length = 380 Score = 201 bits (512), Expect = 4e-52, Method: Composition-based stats. Identities = 57/316 (18%), Positives = 118/316 (37%), Gaps = 51/316 (16%) Query: 44 KLGRGKYSEVFEAINITNNEKVVV-----KILKPVKKKKIKREIKILENLRGGPNIITLA 98 +LGRG + V++ ++ +V + L ++++ K E ++L+ L+ PNI+ Sbjct: 32 ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQH-PNIVRFY 90 Query: 99 DIVKD--PVSRTPALVFEHVNNTDFKQLYQTLT---DYDIRFYMYEILKALDYCHSMG-- 151 D + + LV E + + K + +R + +ILK L + H+ Sbjct: 91 DSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPP 150 Query: 152 IMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDY 211 I+HRD+K N+ I +++ D GLA + + F PE+ ++ YD Sbjct: 151 IIHRDLKCDNIFITGPTGSVKIGDLGLATLMRT-SFAKSVIGTPEFMAPEMYEEH--YDE 207 Query: 212 SLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFND 271 S+D+++ G + M + P+ + Sbjct: 208 SVDVYAFGMCMLEMATSEYPYSECQN---------------------------------- 233 Query: 272 ILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQ 331 + RK + + PE + ++ +R + RL+ R+ + H +F + Sbjct: 234 -AAQIYRKVTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLR 292 Query: 332 ARMGSSSMPGGSTPVS 347 + S+ Sbjct: 293 VELAEEDDCSNSSLAL 308 >5O2B-A nrPDB Length = 285 Score = 201 bits (512), Expect = 4e-52, Method: Composition-based stats. Identities = 56/295 (18%), Positives = 114/295 (38%), Gaps = 51/295 (17%) Query: 44 KLGRGKYSEVFEAINITNNEKVVV-----KILKPVKKKKIKREIKILENLRGGPNIITLA 98 +LGRG + V++ ++ +V + L ++++ K E ++L+ L+ PNI+ Sbjct: 23 ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQH-PNIVRFY 81 Query: 99 DIVKD--PVSRTPALVFEHVNNTDFKQLYQTLT---DYDIRFYMYEILKALDYCHSMG-- 151 D + + LV E + + K + +R + +ILK L + H+ Sbjct: 82 DSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPP 141 Query: 152 IMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDY 211 I+HRD+K N+ I +++ D GLA + + F PE+ ++ YD Sbjct: 142 IIHRDLKCDNIFITGPTGSVKIGDLGLATLMRT-SFAKSVIGTPEFMAPEMYEEH--YDE 198 Query: 212 SLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFND 271 S+D+++ G + M + P+ + Sbjct: 199 SVDVYAFGMCMLEMATSEYPYSECQN---------------------------------- 224 Query: 272 ILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYT 326 + RK + + PE + ++ +R + RL+ R+ + H +F Sbjct: 225 -AAQIYRKVTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAE 278 >6GQK-A nrPDB Length = 328 Score = 200 bits (509), Expect = 9e-52, Method: Composition-based stats. Identities = 58/341 (17%), Positives = 112/341 (32%), Gaps = 78/341 (22%) Query: 11 VYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEA-----INITNNEKV 65 Y D W++ ++ + LG G + +V EA I V Sbjct: 23 SYIDPTQLPYDHKWEFP--------RNRLSFGKTLGAGAFGKVVEATAQGLIKSDAAMTV 74 Query: 66 VVKILKP----VKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDF 121 VK+LKP +++ + E+K+L L NI+ L ++ E+ D Sbjct: 75 AVKMLKPSAHSTEREALMSELKVLSYLGNHENIVNLLGACTH--GGPTLVITEYCCYGDL 132 Query: 122 KQLYQT-------------------LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNV 162 + LT + + Y++ K + + S +HRD+ N+ Sbjct: 133 LNFLRRKRDEFVPYKVAPEDLYKDFLTLEHLLSFSYQVAKGMAFLASKNCIHRDLAARNI 192 Query: 163 MIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLG 219 ++ H + ++ D+GLA Y + +R + PE + + +Y + D+WS G Sbjct: 193 LLTHGNIT-KICDFGLARDIKNDSNYVDKGNARLPVKWMAPESIFN-SVYTFESDVWSYG 250 Query: 220 CMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRK 279 L + + G + ++ K + + E P Sbjct: 251 IFLWELFSLGSSPYPGMPVDSKFYKMIK--------EGFRMSSPEYAP------------ 290 Query: 280 RWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAME 320 E D + D R T ++ ++ Sbjct: 291 ---------------AEMYDIMKTCWDADPDKRPTFKQIVQ 316 >5X02-A nrPDB Length = 347 Score = 200 bits (508), Expect = 1e-51, Method: Composition-based stats. Identities = 53/263 (20%), Positives = 102/263 (38%), Gaps = 50/263 (19%) Query: 11 VYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINI---TNNE--KV 65 Y D + W++ +++ + + LG G + +V A +V Sbjct: 30 FYVDFREYEYDLKWEFP--------RENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQV 81 Query: 66 VVKILKPV----KKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDF 121 VK+LK +++ + E+K++ L NI+ L +S L+FE+ D Sbjct: 82 AVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACT--LSGPIYLIFEYCCYGDL 139 Query: 122 KQLYQT--------------------------LTDYDIRFYMYEILKALDYCHSMGIMHR 155 ++ LT D+ + Y++ K +++ +HR Sbjct: 140 LNYLRSKREKFSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHR 199 Query: 156 DVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLVDYQMYDYS 212 D+ NV++ H + +++ D+GLA Y VR +R + PE L + +Y Sbjct: 200 DLAARNVLVTH-GKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFE-GIYTIK 257 Query: 213 LDMWSLGCMLASMIFRKEPFFHG 235 D+WS G +L + + G Sbjct: 258 SDVWSYGILLWEIFSLGVNPYPG 280 >1ZXE-A nrPDB Length = 303 Score = 200 bits (508), Expect = 1e-51, Method: Composition-based stats. Identities = 67/319 (21%), Positives = 123/319 (38%), Gaps = 70/319 (21%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK--KIKREIKILENLRGGPNII 95 D++ + LG+G + +V +A N ++ +K ++ ++K I E+ +L +L ++ Sbjct: 7 DFEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRHTEEKLSTILSEVMLLASL-NHQYVV 65 Query: 96 TLADIVKD-----------PVSRTPALVFEHVNNTDFKQLYQTLTDYDIR----FYMYEI 140 + T + E+ N L + R +I Sbjct: 66 RYYAAWLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQRDEYWRLFRQI 125 Query: 141 LKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH---------------PG 185 L+AL Y HS GI+HR++KP N+ ID E R +++ D+GLA+ H Sbjct: 126 LEALSYIHSQGIIHRNLKPMNIFID-ESRNVKIGDFGLAKNVHRSLDILKLDSQNLPGSS 184 Query: 186 QEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRI 245 + + + E+L Y+ +DM+SLG + MI+ PF G + + L ++ Sbjct: 185 DNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMIY---PFSTGMERVNILKKL 241 Query: 246 AKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLL 305 V +IE P F+D + +K + L+ Sbjct: 242 RSV-------------SIEFPPDFDDNKMKVEKK--------------------IIRLLI 268 Query: 306 RYDHQSRLTAREAMEHPYF 324 +D R AR + + Sbjct: 269 DHDPNKRPGARTLLNSGWL 287 >5O0Y-A nrPDB Length = 579 Score = 199 bits (507), Expect = 1e-51, Method: Composition-based stats. Identities = 63/316 (19%), Positives = 123/316 (38%), Gaps = 62/316 (19%) Query: 50 YSEVFEAINITNNEKVVVKIL----------KPVKKKKIKREIKILENLRGGPNIITLAD 99 +SEV++A ++T V VKI K K RE +I + L P I+ L D Sbjct: 297 FSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKEL-DHPRIVKLYD 355 Query: 100 IVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYCHSMG--IMH 154 + + V E+ D + +++ + R + +I+ AL Y + + I+H Sbjct: 356 YF-SLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIH 414 Query: 155 RDVKPHNVMI--DHEHRKLRLIDWGLAEFYHPGQEYNVRV--------ASRYFKGPELLV 204 D+KP N+++ ++++ D+GL++ +V + ++ PE V Sbjct: 415 YDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFV 474 Query: 205 ---DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKY 261 + +D+WS+G + ++ ++PF H D L + TE Sbjct: 475 VGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATE--------- 525 Query: 262 NIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEH 321 ++ P+ +V+PEA F+ + L Y + R+ ++ Sbjct: 526 -VQFPPK----------------------PVVTPEAKAFIRRCLAYRKEDRIDVQQLACD 562 Query: 322 PYFYTVVKDQARMGSS 337 PY ++ S Sbjct: 563 PYLLPHIRKSVSTSSP 578 >4GS6-A nrPDB Length = 315 Score = 199 bits (506), Expect = 2e-51, Method: Composition-based stats. Identities = 58/320 (18%), Positives = 106/320 (33%), Gaps = 60/320 (18%) Query: 40 QLVRKLGRGKYSEVFEAINITNNEKVVVKILKPV-KKKKIKREIKILENLRGGPNIITLA 98 ++ +GRG + V +A + V +K ++ ++K E++ L + PNI+ L Sbjct: 12 EVEEVVGRGAFGVVCKAKWRA--KDVAIKQIESESERKAFIVELRQLSRV-NHPNIVKLY 68 Query: 99 DIVKDPVSRTPALVFEHVNNTDFKQLYQ------TLTDYDIRFYMYEILKALDYCHSMG- 151 +P LV E+ + T + + + + Y HSM Sbjct: 69 GACLNP----VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQP 124 Query: 152 --IMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMY 209 ++HRD+KP N+++ L++ D+G A S + PE+ Y Sbjct: 125 KALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQ--THMTNNKGSAAWMAPEVFEGSN-Y 181 Query: 210 DYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRF 269 D++S G +L +I R++PF +G +N P Sbjct: 182 SEKCDVFSWGIILWEVITRRKPFDE--------------IGGPAFRIMWAVHNGTRPPLI 227 Query: 270 NDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTARE---AMEH--PYF 324 ++ + + D R + E M H YF Sbjct: 228 KNLPKPIES---------------------LMTRCWSKDPSQRPSMEEIVKIMTHLMRYF 266 Query: 325 YTVVKDQARMGSSSMPGGST 344 + S+P G Sbjct: 267 PGADEPLQYPCQHSLPPGED 286 >6DBN-A nrPDB Length = 316 Score = 197 bits (502), Expect = 5e-51, Method: Composition-based stats. Identities = 66/313 (21%), Positives = 118/313 (37%), Gaps = 38/313 (12%) Query: 15 VNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAI----NITNNEKVVVKIL 70 V+ +P D + + +R LG G + +V E+V VK L Sbjct: 18 VSEKKPATEVDPTHFEKRFLKR-----IRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSL 72 Query: 71 KPVK----KKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY- 125 KP +K+EI+IL NL NI+ I + L+ E + + K+ Sbjct: 73 KPESGGNHIADLKKEIEILRNLYH-ENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLP 131 Query: 126 ---QTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFY 182 + Y +I K +DY S +HRD+ NV+++ E ++++ D+GL + Sbjct: 132 KNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESE-HQVKIGDFGLTKAI 190 Query: 183 HPGQEYNV----RVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDN 238 +EY R + ++ PE L+ + Y + D+WS G L ++ + Sbjct: 191 ETDKEYYTVKDDRDSPVFWYAPECLMQSKFY-IASDVWSFGVTLHELLTYC------DSD 243 Query: 239 YDQLVRIAKVLGTEDLYDYIDKY--------NIELDPRFNDILGRHSRKRWERFVHSENQ 290 + K++G + + + P D + + RK WE + Sbjct: 244 SSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTS 303 Query: 291 HLVSPEALDFLDK 303 E + L K Sbjct: 304 FQNLIEGFEALLK 316 >5HI2-A nrPDB Length = 283 Score = 197 bits (500), Expect = 8e-51, Method: Composition-based stats. Identities = 56/280 (20%), Positives = 113/280 (40%), Gaps = 23/280 (8%) Query: 32 EWGNQD-DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRG 90 +W D + +++G G + V++ + V VK+L P + + K E+ +L R Sbjct: 14 DWEIPDGQITVGQRIGSGSFGTVYKGKW---HGDVAVKMLTPQQLQAFKNEVGVLRKTRH 70 Query: 91 GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ----TLTDYDIRFYMYEILKALDY 146 NI+ P A+V + + + + + +DY Sbjct: 71 V-NILLFMGYSTKP---QLAIVTQWCEGSSLYHHLHASETKFEMKKLIDIARQTARGMDY 126 Query: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF---YHPGQEYNVRVASRYFKGPELL 203 H+ I+HRD+K +N+ + HE +++ D+GLA + ++ S + PE++ Sbjct: 127 LHAKSIIHRDLKSNNIFL-HEDNTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVI 185 Query: 204 --VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKY 261 D Y + D+++ G +L ++ + P + +N DQ I +++G L + K Sbjct: 186 RMQDSNPYSFQSDVYAFGIVLYELMTGQLP-YSNINNRDQ---IIEMVGRGSLSPDLSKV 241 Query: 262 NIELDPRFNDILGR-HSRKRWERFVHSENQHLVSPEALDF 300 R ++ +KR ER + A + Sbjct: 242 RSNCPKRMKRLMAECLKKKRDERPSFPRILAEIEELAREL 281 >2DQ7-X nrPDB Length = 283 Score = 197 bits (500), Expect = 1e-50, Method: Composition-based stats. Identities = 49/271 (18%), Positives = 111/271 (40%), Gaps = 18/271 (6%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP--VKKKKIKREIKILENLRGGPN 93 ++ QL+++LG G++ EV+ N KV +K LKP + + E +I++ L+ Sbjct: 8 RESLQLIKRLGNGQFGEVWMGTW-NGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDK- 65 Query: 94 IITLADIVKDPVSRTPALVFEHVNNTDFKQLY-----QTLTDYDIRFYMYEILKALDYCH 148 ++ L +V + +V E++N + L ++ ++ + Y Sbjct: 66 LVQLYAVVSEEP---IYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIE 122 Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLVD 205 M +HRD++ N+++ + ++ D+GLA EY R +++ + PE + Sbjct: 123 RMNYIHRDLRSANILVGN-GLICKIADFGLARLIED-NEYTARQGAKFPIKWTAPEAAL- 179 Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIEL 265 Y + D+WS G +L ++ + + G +N + L ++ + D + + Sbjct: 180 YGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELM 239 Query: 266 DPRFNDILGRHSRKRWERFVHSENQHLVSPE 296 + + + + P+ Sbjct: 240 IHCWKKDPEERPTFEYLQSFLEDYFTATEPQ 270 >2OGV-A nrPDB Length = 317 Score = 196 bits (499), Expect = 1e-50, Method: Composition-based stats. Identities = 52/252 (20%), Positives = 98/252 (38%), Gaps = 37/252 (14%) Query: 9 ARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNE----- 63 + + D E W++ +++ Q + LG G + +V EA + Sbjct: 18 SYTFIDPTQLPYNEKWEFP--------RNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVL 69 Query: 64 KVVVKILKPV----KKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNT 119 KV VK+LK +K+ + E+KI+ +L NI+ L ++ E+ Sbjct: 70 KVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTH--GGPVLVITEYCCYG 127 Query: 120 DFKQLYQT-------------LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDH 166 D + L D+ + ++ + + + S +HRDV NV++ + Sbjct: 128 DLLNFLRRKAEADLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTN 187 Query: 167 EHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLA 223 ++ D+GLA Y V+ +R + PE + D +Y D+WS G +L Sbjct: 188 -GHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDC-VYTVQSDVWSYGILLW 245 Query: 224 SMIFRKEPFFHG 235 + + G Sbjct: 246 EIFSLGLNPYPG 257 >3A4O-X nrPDB Length = 286 Score = 196 bits (499), Expect = 1e-50, Method: Composition-based stats. Identities = 49/277 (17%), Positives = 117/277 (42%), Gaps = 20/277 (7%) Query: 22 EYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP--VKKKKIK 79 + WD ++ + ++ +LV++LG G++ EV+ N+ KV VK LKP + + Sbjct: 1 KPWDKDAWEIP---RESIKLVKRLGAGQFGEVWMGY-YNNSTKVAVKTLKPGTMSVQAFL 56 Query: 80 REIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ-----TLTDYDIR 134 E +++ L+ ++ L +V ++ E++ + + + Sbjct: 57 EEANLMKTLQHDK-LVRLYAVVTR--EEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLI 113 Query: 135 FYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVAS 194 + +I + + Y +HRD++ NV++ E ++ D+GLA EY R + Sbjct: 114 DFSAQIAEGMAYIERKNYIHRDLRAANVLV-SESLMCKIADFGLARVIED-NEYTAREGA 171 Query: 195 RY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGT 251 ++ + PE + ++ + D+WS G +L ++ + + G N D + +++ Sbjct: 172 KFPIKWTAPEAI-NFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRM 230 Query: 252 EDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSE 288 + + D+ + + + + + V + Sbjct: 231 PRVENCPDELYDIMKMCWKEKAEERPTFDYLQSVLDD 267 >2H8H-A nrPDB Length = 535 Score = 196 bits (498), Expect = 2e-50, Method: Composition-based stats. Identities = 56/307 (18%), Positives = 115/307 (37%), Gaps = 56/307 (18%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP--VKKKKIKREIKILENLRGGPN 93 ++ +L KLG+G + EV+ V +K LKP + + +E ++++ LR Sbjct: 266 RESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEAFLQEAQVMKKLRHEK- 323 Query: 94 IITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ-----TLTDYDIRFYMYEILKALDYCH 148 ++ L +V + +V E+++ + L + +I + Y Sbjct: 324 LVQLYAVVSEEP---IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVE 380 Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLVD 205 M +HRD++ N+++ E+ ++ D+GLA EY R +++ + PE + Sbjct: 381 RMNYVHRDLRAANILVG-ENLVCKVADFGLARLIED-NEYTARQGAKFPIKWTAPEAAL- 437 Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIEL 265 Y + D+WS G +L + + + G N + L ++ + Y + Sbjct: 438 YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG------------YRMPC 485 Query: 266 DPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAR--EAMEHPY 323 P + L D + + R + + R T +A Y Sbjct: 486 PPECPESLH------------------------DLMCQCWRKEPEERPTFEYLQAFLEDY 521 Query: 324 FYTVVKD 330 F + Sbjct: 522 FTSTEPQ 528 >3BEA-A nrPDB Length = 333 Score = 196 bits (498), Expect = 2e-50, Method: Composition-based stats. Identities = 53/256 (20%), Positives = 100/256 (39%), Gaps = 41/256 (16%) Query: 9 ARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNE----- 63 + + D E W++ +++ Q + LG G + +V EA + Sbjct: 26 SYTFIDPTQLPYNEKWEFP--------RNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVL 77 Query: 64 KVVVKILKPV----KKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNT 119 KV VK+LK +K+ + E+KI+ +L NI+ L ++ E+ Sbjct: 78 KVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTH--GGPVLVITEYCCYG 135 Query: 120 DFKQLYQ-----------------TLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNV 162 D + TL+ D+ + ++ + + + S +HRDV NV Sbjct: 136 DLLNFLRRKSRVLETDPAFAIANSTLSTRDLLHFSSQVAQGMAFLASKNCIHRDVAARNV 195 Query: 163 MIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLG 219 ++ + ++ D+GLA Y V+ +R + PE + D +Y D+WS G Sbjct: 196 LLTN-GHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDC-VYTVQSDVWSYG 253 Query: 220 CMLASMIFRKEPFFHG 235 +L + + G Sbjct: 254 ILLWEIFSLGLNPYPG 269 >4AN9-A nrPDB Length = 301 Score = 196 bits (498), Expect = 2e-50, Method: Composition-based stats. Identities = 64/325 (19%), Positives = 122/325 (37%), Gaps = 52/325 (16%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKI----LKPVKKKKIKREIKILENLRGGP 92 DD++ + +LG G VF+ + + + K+ +KP + +I RE+++L P Sbjct: 9 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHEC-NSP 67 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYC-H 148 I+ ++ EH++ Q+ + + + + ++K L Y Sbjct: 68 YIVGFYGAFYS--DGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLRE 125 Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQM 208 IMHRDVKP N++++ +++L D+G++ + N V +R + PE L Sbjct: 126 KHKIMHRDVKPSNILVNSRG-EIKLCDFGVSGQL-IDEMANEFVGTRSYMSPERLQGT-H 182 Query: 209 YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPR 268 Y D+WS+G L M + P ++ L I E P+ Sbjct: 183 YSVQSDIWSMGLSLVEMAVGRYP-RPPMAIFELLDYIVN----------------EPPPK 225 Query: 269 FNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVV 328 + S E DF++K L + R ++ M H + Sbjct: 226 LPSAV-------------------FSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSD 266 Query: 329 KDQARMGSS--SMPGGSTPVSSANM 351 ++ S G + P + + Sbjct: 267 AEEVDFAGWLCSTIGLNQPSTPTHA 291 >6F3F-A nrPDB Length = 455 Score = 195 bits (497), Expect = 2e-50, Method: Composition-based stats. Identities = 57/307 (18%), Positives = 115/307 (37%), Gaps = 56/307 (18%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP--VKKKKIKREIKILENLRGGPN 93 ++ +L KLG+G + EV+ V +K LKP + + +E ++++ LR Sbjct: 186 RESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEAFLQEAQVMKKLRHEK- 243 Query: 94 IITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ-----TLTDYDIRFYMYEILKALDYCH 148 ++ L +V + +V E++N + L + +I + Y Sbjct: 244 LVQLYAVVSEEP---IYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVE 300 Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLVD 205 M +HRD++ N+++ E+ ++ D+GLA EY R +++ + PE + Sbjct: 301 RMNYVHRDLRAANILVG-ENLVCKVADFGLARLIED-NEYTARQGAKFPIKWTAPEAAL- 357 Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIEL 265 Y + D+WS G +L + + + G N + L ++ + Y + Sbjct: 358 YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG------------YRMPC 405 Query: 266 DPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAR--EAMEHPY 323 P + L D + + R + + R T +A Y Sbjct: 406 PPECPESLH------------------------DLMCQCWRKEPEERPTFEYLQAFLEDY 441 Query: 324 FYTVVKD 330 F + Sbjct: 442 FTSTEPQ 448 >6GVJ-A nrPDB Length = 429 Score = 195 bits (497), Expect = 2e-50, Method: Composition-based stats. Identities = 68/309 (22%), Positives = 118/309 (38%), Gaps = 63/309 (20%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKI-----KREIKILENLR-GGP 92 Y +++++G G S+VF+ +N + +K + + + EI L L+ Sbjct: 146 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 204 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYCHS 149 II L D + + +V E N D + + ++ + Y +L+A+ H Sbjct: 205 KIIRLYDY--EITDQYIYMVME-CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQ 261 Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE---YNVRVASRYFKGPELLVDY 206 GI+H D+KP N +I L+LID+G+A P + +V + + PE + D Sbjct: 262 HGIVHSDLKPANFLIV--DGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDM 319 Query: 207 QM----------YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYD 256 D+WSLGC+L M + K PF + + + Sbjct: 320 SSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF-------------------QQIIN 360 Query: 257 YIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAR 316 I K + +DP K + D L L+ D + R++ Sbjct: 361 QISKLHAIIDPNHEIEFPDIPEK----------------DLQDVLKCCLKRDPKQRISIP 404 Query: 317 EAMEHPYFY 325 E + HPY Sbjct: 405 ELLAHPYVQ 413 >2WTK-C nrPDB Length = 305 Score = 195 bits (497), Expect = 2e-50, Method: Composition-based stats. Identities = 72/331 (21%), Positives = 128/331 (38%), Gaps = 58/331 (17%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK-------PVKKKKIKREIKILENLRG 90 Y + LG G Y +V E ++ + VKILK P + +K+EI++L LR Sbjct: 6 KYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRH 65 Query: 91 GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDY-----DIRFYMYEILKALD 145 N+I L D++ + + +V E+ +++ ++ + Y +++ L+ Sbjct: 66 -KNVIQLVDVLYNEEKQKMYMVMEYCVCG-MQEMLDSVPEKRFPVCQAHGYFCQLIDGLE 123 Query: 146 YCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHP---GQEYNVRVASRYFKGPEL 202 Y HS GI+H+D+KP N+++ L++ G+AE HP S F+ PE+ Sbjct: 124 YLHSQGIVHKDIKPGNLLLTT-GGTLKISALGVAEALHPFAADDTCRTSQGSPAFQPPEI 182 Query: 203 LVDYQMY-DYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKY 261 + + +D+WS G L ++ PF G + Y L++ I K Sbjct: 183 ANGLDTFSGFKVDIWSAGVTLYNITTGLYPF-EGDNIY-------------KLFENIGKG 228 Query: 262 NIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEH 321 + + P D L +L Y+ R + R+ +H Sbjct: 229 SYAIPGDCG------------------------PPLSDLLKGMLEYEPAKRFSIRQIRQH 264 Query: 322 PYFYTVVKDQARMGSSSMPGGSTPVSSANMM 352 +F A P T +M Sbjct: 265 SWFRK-KHPPAEAPVPIPPSPDTKDRWRSMT 294 >3KRL-A nrPDB Length = 335 Score = 195 bits (495), Expect = 3e-50, Method: Composition-based stats. Identities = 52/258 (20%), Positives = 99/258 (38%), Gaps = 43/258 (16%) Query: 9 ARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNE----- 63 + + D E W++ +++ Q + LG G + +V EA + Sbjct: 26 SYTFIDPTQLPYNEKWEFP--------RNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVL 77 Query: 64 KVVVKILKPV----KKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNT 119 KV VK+LK +K+ + E+KI+ +L NI+ L ++ E+ Sbjct: 78 KVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTH--GGPVLVITEYCCYG 135 Query: 120 DFKQLYQT-------------------LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPH 160 D + L+ D+ + ++ + + + S +HRDV Sbjct: 136 DLLNFLRRKRPPGLEYSYNPSHNPEEQLSSRDLLHFSSQVAQGMAFLASKNCIHRDVAAR 195 Query: 161 NVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWS 217 NV++ + ++ D+GLA Y V+ +R + PE + D +Y D+WS Sbjct: 196 NVLLTN-GHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDC-VYTVQSDVWS 253 Query: 218 LGCMLASMIFRKEPFFHG 235 G +L + + G Sbjct: 254 YGILLWEIFSLGLNPYPG 271 >3DLS-A nrPDB Length = 335 Score = 195 bits (495), Expect = 3e-50, Method: Composition-based stats. Identities = 76/369 (20%), Positives = 133/369 (36%), Gaps = 70/369 (18%) Query: 18 HRPREYWDYES-HVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK- 75 P + + E E Y + LG G + V+ A++ N++VVVK +K K Sbjct: 4 EEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVL 63 Query: 76 ----------KKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFE-HVNNTD---F 121 K+ EI IL + NII + DI ++ LV E H + D F Sbjct: 64 EDCWIEDPKLGKVTLEIAILSRVEHA-NIIKVLDIFENQGFFQ--LVMEKHGSGLDLFAF 120 Query: 122 KQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF 181 + L + + +++ A+ Y I+HRD+K N++I E ++LID+G A + Sbjct: 121 IDRHPRLDEPLASYIFRQLVSAVGYLRLKDIIHRDIKDENIVI-AEDFTIKLIDFGSAAY 179 Query: 182 YHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQ 241 G+ + + + PE+L+ L+MWSLG L +++F + PF + + Sbjct: 180 LERGKLFYTFCGTIEYCAPEVLMGNPYRGPELEMWSLGVTLYTLVFEENPFCELEETVE- 238 Query: 242 LVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFL 301 +LVS E + + Sbjct: 239 -------------------------------------------AAIHPPYLVSKELMSLV 255 Query: 302 DKLLRYDHQSRLTAREAMEHPY------FYTVVKDQARMGSSSMPGGSTPVSSANMMSGI 355 LL+ + R T + + P+ ++ + G + S + Sbjct: 256 SGLLQPVPERRTTLEKLVTDPWVTQPVNLADYTWEEVFRVNKPESGVLSAASLEMGNRSL 315 Query: 356 SSVPTPSPL 364 S V L Sbjct: 316 SDVAQAQEL 324 >4XUF-A nrPDB Length = 297 Score = 195 bits (495), Expect = 3e-50, Method: Composition-based stats. Identities = 51/244 (20%), Positives = 99/244 (40%), Gaps = 43/244 (17%) Query: 31 VEWG-NQDDYQLVRKLGRGKYSEVFEAINI---TNNE--KVVVKILKPV----KKKKIKR 80 ++W +++ + + LG G + +V A +V VK+LK +++ + Sbjct: 2 LKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMS 61 Query: 81 EIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT------------- 127 E+K++ L NI+ L +S L+FE+ D ++ Sbjct: 62 ELKMMTQLGSHENIVNLLGACT--LSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYE 119 Query: 128 -------------LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLI 174 LT D+ + Y++ K +++ +HRD+ NV++ H + +++ Sbjct: 120 NQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTH-GKVVKIC 178 Query: 175 DWGLAEFYHPGQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEP 231 D+GLA Y VR +R + PE L + +Y D+WS G +L + Sbjct: 179 DFGLARDIMSDSNYVVRGNARLPVKWMAPESLFE-GIYTIKSDVWSYGILLWEIFSLGVN 237 Query: 232 FFHG 235 + G Sbjct: 238 PYPG 241 >3G0E-A nrPDB Length = 336 Score = 194 bits (494), Expect = 4e-50, Method: Composition-based stats. Identities = 61/343 (17%), Positives = 114/343 (33%), Gaps = 80/343 (23%) Query: 11 VYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEA-----INITNNEKV 65 VY D W++ ++ + LG G + +V EA I V Sbjct: 28 VYIDPTQLPYDHKWEFP--------RNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTV 79 Query: 66 VVKILKP----VKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDF 121 VK+LKP +++ + E+K+L L NI+ L + ++ E+ D Sbjct: 80 AVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACT--IGGPTLVITEYCCYGDL 137 Query: 122 KQLYQTLTDYDI---------------------RFYMYEILKALDYCHSMGIMHRDVKPH 160 + D I + Y++ K + + S +HRD+ Sbjct: 138 LNFLRRKRDSFICSKTSPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAAR 197 Query: 161 NVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWS 217 N+++ H R ++ D+GLA Y V+ +R + PE + + +Y + D+WS Sbjct: 198 NILLTH-GRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNC-VYTFESDVWS 255 Query: 218 LGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHS 277 G L + + G + ++ K + + E P Sbjct: 256 YGIFLWELFSLGSSPYPGMPVDSKFYKMIK--------EGFRMLSPEHAP---------- 297 Query: 278 RKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAME 320 E D + D R T ++ ++ Sbjct: 298 -----------------AEMYDIMKTCWDADPLKRPTFKQIVQ 323 >3CJF-A nrPDB Length = 309 Score = 194 bits (494), Expect = 5e-50, Method: Composition-based stats. Identities = 65/338 (19%), Positives = 127/338 (37%), Gaps = 69/338 (20%) Query: 14 DVNTHRPREYWD---YESHVVEWGNQDDYQLVRKLGRGKYSEVFEA----INIT-NNEKV 65 D + E+ + Y++ E+ +D L + LGRG + +V EA I+ T V Sbjct: 2 DPDELPLDEHCERLPYDASKWEF-PRDRLNLGKPLGRGAFGQVIEADAFGIDKTATCRTV 60 Query: 66 VVKILKP----VKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDF 121 VK+LK + + + E+KIL ++ N++ L P +V E + Sbjct: 61 AVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIV-EFCKFGNL 119 Query: 122 KQLYQT---------------LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDH 166 ++ LT + Y +++ K +++ S +HRD+ N+++ Sbjct: 120 STYLRSKRNEFVPYKDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSE 179 Query: 167 EHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLA 223 ++ +++ D+GLA + +Y + +R + PE + D ++Y D+WS G +L Sbjct: 180 KN-VVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFD-RVYTIQSDVWSFGVLLW 237 Query: 224 SMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWER 283 + + G +++D F L +R R Sbjct: 238 EIFSLGASPYPG---------------------------VKIDEEFCRRLKEGTRMRAPD 270 Query: 284 FVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEH 321 + E + + R T E +EH Sbjct: 271 YTTPEMYQTMLD--------CWHGEPSQRPTFSELVEH 300 >5H2U-A nrPDB Length = 267 Score = 194 bits (494), Expect = 5e-50, Method: Composition-based stats. Identities = 54/262 (20%), Positives = 109/262 (41%), Gaps = 25/262 (9%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK---KKKIKREIKILENLRGGP 92 ++++ L RKLG G + EVFE + + +V +K++ ++ ++ EI+ ++ LR Sbjct: 5 REEFTLCRKLGSGYFGEVFEGLWK-DRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRH-K 62 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ-----TLTDYDIRFYMYEILKALDYC 147 +I+ L +V V ++ E + +L + L ++ +++ + + Y Sbjct: 63 HILALYAVV--SVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYL 120 Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY-FKGPELLVDY 206 S +HRD+ N+++ E+ ++ D+GLA + Y + PE L Sbjct: 121 ESQNYIHRDLAARNILVG-ENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEAL-SR 178 Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYN---- 262 Y D+WS G +L M R + + G N++ +R+ + + Sbjct: 179 GHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLML 238 Query: 263 ------IELDPRFNDILGRHSR 278 E P F + R S Sbjct: 239 TCWCRDPEQRPTFKALRERLSS 260 >2XYN-A nrPDB Length = 292 Score = 194 bits (493), Expect = 6e-50, Method: Composition-based stats. Identities = 52/274 (18%), Positives = 115/274 (41%), Gaps = 33/274 (12%) Query: 25 DYESHVVEWGNQDDYQLVR-------KLGRGKYSEVFEAINITNNEKVVVKILK--PVKK 75 D + + + + D +++ R KLG G+Y EV+ + + V VK LK ++ Sbjct: 13 DLGTENLYFQSMDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEV 72 Query: 76 KKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDI-- 133 ++ +E +++ ++ PN++ L + + +V E++ + + ++ Sbjct: 73 EEFLKEAAVMKEIKH-PNLVQLLGVCT--LEPPFYIVTEYMPYGNLLDYLRECNREEVTA 129 Query: 134 ---RFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNV 190 + +I A++Y +HRD+ N ++ E+ +++ D+GL+ G Y Sbjct: 130 VVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVG-ENHVVKVADFGLSRLM-TGDTYTA 187 Query: 191 RVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHD---NYDQLVR 244 +++ + PE L Y + D+W+ G +L + + G D YD L + Sbjct: 188 HAGAKFPIKWTAPESLA-YNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEK 246 Query: 245 IAKVLGTE-------DLYDYIDKYNIELDPRFND 271 ++ E +L K++ P F + Sbjct: 247 GYRMEQPEGCPPKVYELMRACWKWSPADRPSFAE 280 >3HMP-A nrPDB Length = 342 Score = 194 bits (492), Expect = 7e-50, Method: Composition-based stats. Identities = 68/309 (22%), Positives = 118/309 (38%), Gaps = 63/309 (20%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKI-----KREIKILENLR-GGP 92 Y +++++G G S+VF+ +N + +K + + + EI L L+ Sbjct: 58 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 116 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYCHS 149 II L D + + +V E N D + + ++ + Y +L+A+ H Sbjct: 117 KIIRLYDY--EITDQYIYMVME-CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQ 173 Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE---YNVRVASRYFKGPELLVDY 206 GI+H D+KP N +I L+LID+G+A P + +V + + PE + D Sbjct: 174 HGIVHSDLKPANFLIV--DGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDM 231 Query: 207 QM----------YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYD 256 D+WSLGC+L M + K PF + + + Sbjct: 232 SSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF-------------------QQIIN 272 Query: 257 YIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAR 316 I K + +DP K + D L L+ D + R++ Sbjct: 273 QISKLHAIIDPNHEIEFPDIPEK----------------DLQDVLKCCLKRDPKQRISIP 316 Query: 317 EAMEHPYFY 325 E + HPY Sbjct: 317 ELLAHPYVQ 325 >1S9I-A nrPDB Length = 354 Score = 194 bits (492), Expect = 7e-50, Method: Composition-based stats. Identities = 59/314 (18%), Positives = 118/314 (37%), Gaps = 24/314 (7%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKI----LKPVKKKKIKREIKILENLRGGP 92 DD++ + +LG G V + + + + K+ +KP + +I RE+++L P Sbjct: 16 DDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHEC-NSP 74 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYC-H 148 I+ ++ EH++ Q+ + + + + +L+ L Y Sbjct: 75 YIVGFYGAFYS--DGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLRE 132 Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQM 208 IMHRDVKP N++++ +++L D+G++ N V +R + PE L Sbjct: 133 KHQIMHRDVKPSNILVNSRG-EIKLCDFGVSGQLIDSMA-NSFVGTRSYMAPERLQGT-H 189 Query: 209 YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPR 268 Y D+WS+G L + + P + + V+ E+ + R Sbjct: 190 YSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRPPGR 249 Query: 269 FNDILGRHSRKRWERF----------VHSENQHLVSPEALDFLDKLLRYDHQSRLTAREA 318 G SR F + +P+ +F++K L + R + Sbjct: 250 PVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADLKML 309 Query: 319 MEHPYFYTVVKDQA 332 H + ++ Sbjct: 310 TNHTFIKRSEVEEV 323 >5SYS-A nrPDB Length = 286 Score = 194 bits (492), Expect = 7e-50, Method: Composition-based stats. Identities = 56/307 (18%), Positives = 114/307 (37%), Gaps = 56/307 (18%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP--VKKKKIKREIKILENLRGGPN 93 ++ +L KLG+G + E + V +K LKP + + +E ++++ LR Sbjct: 17 RESLRLEVKLGQGCFGECWMGTWNGTTR-VAIKTLKPGTMSPEAFLQEAQVMKKLRHEK- 74 Query: 94 IITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ-----TLTDYDIRFYMYEILKALDYCH 148 ++ L +V + +V E+++ + L + +I + Y Sbjct: 75 LVQLYAVVSEEP---IYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVE 131 Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLVD 205 M +HRD++ N+++ E+ ++ D+GLA EY R +++ + PE + Sbjct: 132 RMNYVHRDLRAANILVG-ENLVCKVADFGLARLIED-NEYTARQGAKFPIKWTAPEAAL- 188 Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIEL 265 Y + D+WS G +L + + + G N + L ++ + Y + Sbjct: 189 YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG------------YRMPC 236 Query: 266 DPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAR--EAMEHPY 323 P + L D + + R D + R T +A Y Sbjct: 237 PPECPESLH------------------------DLMCQCWRKDPEERPTFEYLQAFLEDY 272 Query: 324 FYTVVKD 330 F + Sbjct: 273 FTSTEPQ 279 >3OMV-A nrPDB Length = 307 Score = 194 bits (492), Expect = 7e-50, Method: Composition-based stats. Identities = 55/285 (19%), Positives = 112/285 (39%), Gaps = 36/285 (12%) Query: 16 NTHRPRE------YWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKI 69 N RPR YW+ E+ V + +G G + V++ + V VKI Sbjct: 17 NKIRPRGQRDSSYYWEIEASEVMLSTR--------IGSGSFGTVYKGKW---HGDVAVKI 65 Query: 70 LK-----PVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQL 124 LK P + + + E+ +L R NI+ A+V + + + Sbjct: 66 LKVVDPTPEQFQAFRNEVAVLRKTRHV-NILLFMGY---MTKDNLAIVTQWCEGSSLYKH 121 Query: 125 YQ----TLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE 180 + + + + +DY H+ I+HRD+K +N+ + HE +++ D+GLA Sbjct: 122 LHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFL-HEGLTVKIGDFGLAT 180 Query: 181 F---YHPGQEYNVRVASRYFKGPELL--VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHG 235 + Q+ S + PE++ D + + D++S G +L ++ + P+ H Sbjct: 181 VKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHI 240 Query: 236 HDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKR 280 ++ + + + + DL + D + + +R Sbjct: 241 NNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEER 285 >2VWV-A nrPDB Length = 302 Score = 193 bits (491), Expect = 9e-50, Method: Composition-based stats. Identities = 63/323 (19%), Positives = 122/323 (37%), Gaps = 44/323 (13%) Query: 25 DYESHVVEWGNQDDY---QLVRKLGRGKYSEVFEAINITNNEK---VVVKILK----PVK 74 D V E+ + D ++ +G G++ EV +K V +K LK + Sbjct: 1 DPNEAVREFAKEIDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQ 60 Query: 75 KKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ----TLTD 130 +++ E I+ PNII L +V + S ++ E + N + T Sbjct: 61 RREFLSEASIMGQFEH-PNIIRLEGVVTN--SMPVMILTEFMENGALDSFLRLNDGQFTV 117 Query: 131 YDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHP---GQE 187 + + I + Y M +HRD+ N++++ + ++ D+GL+ F Sbjct: 118 IQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNS-NLVCKVSDFGLSRFLEENSSDPT 176 Query: 188 YNVRVASR---YFKGPELLVDYQMYDYSLDMWSLGCMLAS-MIFRKEPFFHGHDNYDQLV 243 + + + PE + ++ + + D WS G ++ M F + P++ N D + Sbjct: 177 ETSSLGGKIPIRWTAPEAIA-FRKFTSASDAWSYGIVMWEVMSFGERPYWD-MSNQDVIN 234 Query: 244 RIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDK 303 I + Y + P L + W++ N P+ + LDK Sbjct: 235 AIEQ------------DYRLPPPPDCPTSLHQLMLDCWQK---DRNARPRFPQVVSALDK 279 Query: 304 LLRYDHQSRLTARE--AMEHPYF 324 ++R ++ ARE HP Sbjct: 280 MIRNPASLKIVARENGGASHPLL 302 >3BGP-A nrPDB Length = 333 Score = 193 bits (491), Expect = 1e-49, Method: Composition-based stats. Identities = 68/311 (21%), Positives = 120/311 (38%), Gaps = 61/311 (19%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK---------KIKREIKILE 86 + YQ+ LG G + V+ I +++N V +K ++ + ++ E+ +L+ Sbjct: 55 ESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLK 114 Query: 87 NLRGG-PNIITLADIVKDPVSRTPALVFEHVNNT----DFKQLYQTLTDYDIRFYMYEIL 141 + G +I L D + P S L+ E DF L + R + +++L Sbjct: 115 KVSSGFSGVIRLLDWFERPDSF--VLILERPEPVQDLFDFITERGALQEELARSFFWQVL 172 Query: 142 KALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPE 201 +A+ +CH+ G++HRD+K N++ID +L+LID+G Y +R + PE Sbjct: 173 EAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKD-TVYTDFDGTRVYSPPE 231 Query: 202 LLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKY 261 + ++ + S +WSLG +L M+ PF H + I + Sbjct: 232 WIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE--------------------IIRG 271 Query: 262 NIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEH 321 + R VS E + L R T E H Sbjct: 272 QVFFRQR------------------------VSSECQHLIRWCLALRPSDRPTFEEIQNH 307 Query: 322 PYFYTVVKDQA 332 P+ V+ Q Sbjct: 308 PWMQDVLLPQE 318 >3IO7-A nrPDB Length = 313 Score = 193 bits (490), Expect = 1e-49, Method: Composition-based stats. Identities = 46/216 (21%), Positives = 98/216 (45%), Gaps = 18/216 (8%) Query: 27 ESHVVEWGNQDDYQLVRKLGRGKYSEVFEAI----NITNNEKVVVKILKPVKKK---KIK 79 SH + + + +++LG+G + V E V VK L+ ++ + Sbjct: 18 GSHNMTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFE 77 Query: 80 REIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDY----DIRF 135 REI+IL++L+ NI+ + R L+ E++ + Q + + Sbjct: 78 REIEILKSLQHD-NIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQ 136 Query: 136 YMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVR---- 191 Y +I K ++Y + +HRD+ N+++++E+R +++ D+GL + +EY Sbjct: 137 YTSQICKGMEYLGTKRYIHRDLATRNILVENENR-VKIGDFGLTKVLPQDKEYYKVKEPG 195 Query: 192 VASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIF 227 + ++ PE L + + + + D+WS G +L + Sbjct: 196 ESPIFWYAPESLTESK-FSVASDVWSFGVVLYELFT 230 >2R2P-A nrPDB Length = 295 Score = 193 bits (490), Expect = 1e-49, Method: Composition-based stats. Identities = 63/310 (20%), Positives = 120/310 (38%), Gaps = 41/310 (13%) Query: 20 PREYWDYESHVVEWGNQDD---YQLVRKLGRGKYSEVFEAINITNNEK---VVVKILKPV 73 P Y D V E+ + + + R +G G++ EV ++ V +K LK Sbjct: 2 PHTYEDPNQAVHEFAKEIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVG 61 Query: 74 KKKKIKR----EIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT-- 127 +K +R E I+ PNII L +V S+ +V E++ N + Sbjct: 62 YTEKQRRDFLGEASIMGQF-DHPNIIHLEGVVT--KSKPVMIVTEYMENGSLDTFLKKND 118 Query: 128 --LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPG 185 T + + I + Y MG +HRD+ N++I+ + ++ D+GL+ Sbjct: 119 GQFTVIQLVGMLRGISAGMKYLSDMGYVHRDLAARNILINS-NLVCKVSDFGLSRVLEDD 177 Query: 186 QE--YNVRVA--SRYFKGPELLVDYQMYDYSLDMWSLGCMLASMI-FRKEPFFHGHDNYD 240 E Y R + PE + ++ + + D+WS G ++ ++ + + P++ N D Sbjct: 178 PEAAYTTRGGKIPIRWTAPEAIA-FRKFTSASDVWSYGIVMWEVVSYGERPYWE-MTNQD 235 Query: 241 QLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDF 300 + + + D L + W++ N E ++ Sbjct: 236 VIKAVEEGYRLPSPMD------------CPAALYQLMLDCWQK---ERNSRPKFDEIVNM 280 Query: 301 LDKLLRYDHQ 310 LDKL+R + Sbjct: 281 LDKLIR-NPA 289 >5AP3-A nrPDB Length = 313 Score = 192 bits (489), Expect = 2e-49, Method: Composition-based stats. Identities = 68/309 (22%), Positives = 118/309 (38%), Gaps = 63/309 (20%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKI-----KREIKILENLR-GGP 92 Y +++++G G S+VF+ +N + +K + + + EI L L+ Sbjct: 30 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 88 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYCHS 149 II L D + + +V E N D + + ++ + Y +L+A+ H Sbjct: 89 KIIRLYDY--EITDQYIYMVME-CGNIDLNGWLKKKKSIDPWERKSYWKNMLEAVHTIHQ 145 Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE---YNVRVASRYFKGPELLVDY 206 GI+H D+KP N +I L+LID+G+A P + +V + + PE + D Sbjct: 146 HGIVHSDLKPANFLIV--DGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDM 203 Query: 207 QM----------YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYD 256 D+WSLGC+L M + K PF + + + Sbjct: 204 SSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF-------------------QQIIN 244 Query: 257 YIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAR 316 I K + +DP K + D L L+ D + R++ Sbjct: 245 QISKLHAIIDPNHEIEFPDIPEK----------------DLQDVLKCCLKRDPKQRISIP 288 Query: 317 EAMEHPYFY 325 E + HPY Sbjct: 289 ELLAHPYVQ 297 >4EQM-A nrPDB Length = 294 Score = 192 bits (489), Expect = 2e-49, Method: Composition-based stats. Identities = 67/293 (22%), Positives = 130/293 (44%), Gaps = 27/293 (9%) Query: 27 ESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL------KPVKKKKIKR 80 SH++ + Y++V KLG G S V+ A + N KV +K + K K+ +R Sbjct: 1 GSHMIGKIINERYKIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETLKRFER 60 Query: 81 EIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYM 137 E+ L NI+++ D+ D LV E++ + ++ L+ + Sbjct: 61 EVHNSSQLSHQ-NIVSMIDV--DEEDDCYYLVMEYIEGPTLSEYIESHGPLSVDTAINFT 117 Query: 138 YEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ--EYNVRVASR 195 +IL + + H M I+HRD+KP N++ID ++ L++ D+G+A+ + N + + Sbjct: 118 NQILDGIKHAHDMRIVHRDIKPQNILIDS-NKTLKIFDFGIAKALSETSLTQTNHVLGTV 176 Query: 196 YFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLY 255 + PE + D D++S+G +L M+ + PF N + V IA + + Sbjct: 177 QYFSPE-QAKGEATDECTDIYSIGIVLYEMLVGEPPF-----NGETAVSIAIKHIQDSVP 230 Query: 256 DYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYD 308 + ++ ++++ R + K N++ E D L +L + Sbjct: 231 NVTTDVRKDIPQSLSNVILRATEKD------KANRYKTIQEMKDDLSSVLHEN 277 >4RC3-A nrPDB Length = 289 Score = 192 bits (488), Expect = 2e-49, Method: Composition-based stats. Identities = 68/311 (21%), Positives = 120/311 (38%), Gaps = 61/311 (19%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK---------KIKREIKILE 86 + YQ+ LG G + V+ I +++N V +K ++ + ++ E+ +L+ Sbjct: 11 ESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLK 70 Query: 87 NLRGG-PNIITLADIVKDPVSRTPALVFEHVNNT----DFKQLYQTLTDYDIRFYMYEIL 141 + G +I L D + P S L+ E DF L + R + +++L Sbjct: 71 KVSSGFSGVIRLLDWFERPDSF--VLILERPEPVQDLFDFITERGALQEELARSFFWQVL 128 Query: 142 KALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPE 201 +A+ +CH+ G++HRD+K N++ID +L+LID+G Y +R + PE Sbjct: 129 EAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKD-TVYTDFDGTRVYSPPE 187 Query: 202 LLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKY 261 + ++ + S +WSLG +L M+ PF H + I + Sbjct: 188 WIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE--------------------IIRG 227 Query: 262 NIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEH 321 + R VS E + L R T E H Sbjct: 228 QVFFRQR------------------------VSSECQHLIRWCLALRPSDRPTFEEIQNH 263 Query: 322 PYFYTVVKDQA 332 P+ V+ Q Sbjct: 264 PWMQDVLLPQE 274 >4IAN-A nrPDB Length = 358 Score = 192 bits (488), Expect = 2e-49, Method: Composition-based stats. Identities = 69/326 (21%), Positives = 133/326 (40%), Gaps = 43/326 (13%) Query: 38 DYQLVRKLGRGKYSEVFEAINI-TNNEKVVVKILKPVK--KKKIKREIKILENLRGGP-- 92 Y + G+G +S V A + N++V VKI++ + +K +E++ L+ L Sbjct: 31 RYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTGLKELEFLKKLNDADPD 90 Query: 93 ---NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT------LTDYDIRFYMYEILKA 143 + + L + LVFE ++ + +++ + L +R Y ++ A Sbjct: 91 DKFHCLRLFRHFYHK--QHLCLVFEPLS-MNLREVLKKYGKDVGLHIKAVRSYSQQLFLA 147 Query: 144 LDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELL 203 L I+H D+KP N++++ L+L D+G A + SR+++ PE++ Sbjct: 148 LKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASHVADND-ITPYLVSRFYRAPEII 206 Query: 204 VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTED---------- 253 + + YDY +DMWS+GC L + K F G N L + G Sbjct: 207 IG-KSYDYGIDMWSVGCTLYELYTGKI-LFPGKTNNHMLKLAMDLKGKMPNKMIRKGVFK 264 Query: 254 --------LYDYIDKYNIELDPRFNDILGRHSRKRWERFV-----HSENQHLVSPEALDF 300 + YI+ + + + + K + E+Q + D Sbjct: 265 DQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLADLIGCQRLPEDQRKKVHQLKDL 324 Query: 301 LDKLLRYDHQSRLTAREAMEHPYFYT 326 LD++L D R++ +A++H + Sbjct: 325 LDQILMLDPAKRISINQALQHAFIQE 350 >2ZMD-A nrPDB Length = 390 Score = 192 bits (487), Expect = 3e-49, Method: Composition-based stats. Identities = 68/309 (22%), Positives = 118/309 (38%), Gaps = 63/309 (20%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKI-----KREIKILENLR-GGP 92 Y +++++G G S+VF+ +N + +K + + + EI L L+ Sbjct: 58 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 116 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYCHS 149 II L D + + +V E N D + + ++ + Y +L+A+ H Sbjct: 117 KIIRLYDY--EITDQYIYMVME-CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQ 173 Query: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE---YNVRVASRYFKGPELLVDY 206 GI+H D+KP N +I L+LID+G+A P + +V + + PE + D Sbjct: 174 HGIVHSDLKPANFLIV--DGMLKLIDFGIANQMQPDTTSVVKDSQVGAVNYMPPEAIKDM 231 Query: 207 QM----------YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYD 256 D+WSLGC+L M + K PF + + + Sbjct: 232 SSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF-------------------QQIIN 272 Query: 257 YIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAR 316 I K + +DP K + D L L+ D + R++ Sbjct: 273 QISKLHAIIDPNHEIEFPDIPEK----------------DLQDVLKCCLKRDPKQRISIP 316 Query: 317 EAMEHPYFY 325 E + HPY Sbjct: 317 ELLAHPYVQ 325 >4XEY-B nrPDB Length = 408 Score = 192 bits (487), Expect = 3e-49, Method: Composition-based stats. Identities = 56/343 (16%), Positives = 126/343 (36%), Gaps = 63/343 (18%) Query: 4 PVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNE 63 P P R + + + W+ E + D + KLG G+Y EV+E + + Sbjct: 101 PAPKRNKPTVYGVSPN-YDKWEME--------RTDITMKHKLGGGQYGEVYEGVWKKYSL 151 Query: 64 KVVVKILK--PVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDF 121 V VK LK ++ ++ +E +++ ++ PN++ L + ++ E + + Sbjct: 152 TVAVKTLKEDTMEVEEFLKEAAVMKEIKH-PNLVQLLGVCTREP--PFYIITEFMTYGNL 208 Query: 122 KQLYQTLTDYDI-----RFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDW 176 + ++ + +I A++Y +HRD+ N ++ E+ +++ D+ Sbjct: 209 LDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVG-ENHLVKVADF 267 Query: 177 GLAEFYHPGQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFF 233 GL+ G Y +++ + PE L Y + D+W+ G +L + + Sbjct: 268 GLSRLM-TGDTYTAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSPY 325 Query: 234 HGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLV 293 G D L ++ ++L E+ E Sbjct: 326 PGID----LSQVYELL--------------------------------EKDYRMERPEGC 349 Query: 294 SPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGS 336 + + + +++ R + E H F T+ ++ + Sbjct: 350 PEKVYELMRACWQWNPSDRPSFAEI--HQAFETMFQESSISDE 390 >5HIE-A nrPDB Length = 302 Score = 192 bits (487), Expect = 3e-49, Method: Composition-based stats. Identities = 50/279 (17%), Positives = 110/279 (39%), Gaps = 21/279 (7%) Query: 32 EWGNQD-DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRG 90 +W D + +++G G + V++ + V VK+L P + + K E+ +L R Sbjct: 30 DWEIPDGQITVGQRIGSGSFGTVYKGKW---HGDVAVKMLTPQQLQAFKNEVGVLRKTRH 86 Query: 91 GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ----TLTDYDIRFYMYEILKALDY 146 NI+ P A+V + + + + + +DY Sbjct: 87 V-NILLFMGYSTKP---QLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDY 142 Query: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF---YHPGQEYNVRVASRYFKGPELL 203 H+ I+HRD+K +N+ + HE +++ D+GLA + ++ S + PE++ Sbjct: 143 LHAKSIIHRDLKSNNIFL-HEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVI 201 Query: 204 --VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKY 261 D Y + D+++ G +L ++ + P+ + ++ + + + + DL Sbjct: 202 RMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNC 261 Query: 262 NIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDF 300 + + +KR ER + + + A Sbjct: 262 PKAMK---RLMAECLKKKRDERPLFPQILASIELLARSL 297 >5TUR-A nrPDB Length = 404 Score = 192 bits (487), Expect = 3e-49, Method: Composition-based stats. Identities = 68/311 (21%), Positives = 120/311 (38%), Gaps = 61/311 (19%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK---------KIKREIKILE 86 + YQ+ LG G + V+ I +++N V +K ++ + ++ E+ +L+ Sbjct: 126 ESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLK 185 Query: 87 NLRGG-PNIITLADIVKDPVSRTPALVFEHVNNT----DFKQLYQTLTDYDIRFYMYEIL 141 + G +I L D + P S L+ E DF L + R + +++L Sbjct: 186 KVSSGFSGVIRLLDWFERPDSF--VLILERPEPVQDLFDFITERGALQEELARSFFWQVL 243 Query: 142 KALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPE 201 +A+ +CH+ G++HRD+K N++ID +L+LID+G Y +R + PE Sbjct: 244 EAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKD-TVYTDFDGTRVYSPPE 302 Query: 202 LLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKY 261 + ++ + S +WSLG +L M+ PF H + I + Sbjct: 303 WIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE--------------------IIRG 342 Query: 262 NIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEH 321 + R VS E + L R T E H Sbjct: 343 QVFFRQR------------------------VSSECQHLIRWCLALRPSDRPTFEEIQNH 378 Query: 322 PYFYTVVKDQA 332 P+ V+ Q Sbjct: 379 PWMQDVLLPQE 389 >2PL0-A nrPDB Length = 289 Score = 192 bits (487), Expect = 3e-49, Method: Composition-based stats. Identities = 54/297 (18%), Positives = 118/297 (39%), Gaps = 27/297 (9%) Query: 15 VNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK--P 72 + T +P++ W + V ++ +LV +LG G++ EV+ + KV VK LK Sbjct: 4 MQTQKPQKPWWEDEWEVP---RETLKLVERLGAGQFGEVWMGY-YNGHTKVAVKSLKQGS 59 Query: 73 VKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----- 127 + E +++ L+ ++ L +V ++ E++ N +T Sbjct: 60 MSPDAFLAEANLMKQLQHQR-LVRLYAVV---TQEPIYIITEYMENGSLVDFLKTPSGIK 115 Query: 128 LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE 187 LT + +I + + + +HRD++ N+++ + ++ D+GLA E Sbjct: 116 LTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILV-SDTLSCKIADFGLARLIED-NE 173 Query: 188 YNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLV- 243 Y R +++ + PE + +Y + D+WS G +L ++ + G N + + Sbjct: 174 YTAREGAKFPIKWTAPEAI-NYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQN 232 Query: 244 -----RIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSP 295 R+ + + + + + P + F +E Q+ P Sbjct: 233 LERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP 289 >4R7H-A nrPDB Length = 343 Score = 191 bits (486), Expect = 3e-49, Method: Composition-based stats. Identities = 52/265 (19%), Positives = 98/265 (36%), Gaps = 50/265 (18%) Query: 9 ARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNE----- 63 + + D E W++ +++ Q + LG G + +V EA + Sbjct: 30 SYTFIDPTQLPYNEKWEFP--------RNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVL 81 Query: 64 KVVVKILKPV----KKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNT 119 KV VK+LK +K+ + E+KI+ +L NI+ L ++ E+ Sbjct: 82 KVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTH--GGPVLVITEYCTYG 139 Query: 120 DFKQLYQT--------------------------LTDYDIRFYMYEILKALDYCHSMGIM 153 D + L D+ + ++ + + + S + Sbjct: 140 DLLNFLRRKAEAMLGPSLSPGQDPEGLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCI 199 Query: 154 HRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLVDYQMYD 210 HRDV NV++ + ++ D+GLA Y V+ +R + PE + D +Y Sbjct: 200 HRDVAARNVLLTN-GHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFD-SVYT 257 Query: 211 YSLDMWSLGCMLASMIFRKEPFFHG 235 D+WS G +L + + G Sbjct: 258 VQSDVWSYGILLWEIFSLGLNPYPG 282 >3DKO-A nrPDB Length = 318 Score = 191 bits (485), Expect = 5e-49, Method: Composition-based stats. Identities = 58/311 (18%), Positives = 117/311 (37%), Gaps = 41/311 (13%) Query: 19 RPREYWDYESHVVEWGNQDD---YQLVRKLGRGKYSEVFEAINITNNEK---VVVKILKP 72 P Y D V ++ + D ++ R +G G++ EV ++ V +K LK Sbjct: 22 DPETYEDPNRAVHQFAKELDASCIKIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKV 81 Query: 73 VKKKKIKR----EIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT- 127 +K +R E I+ PN++ L +V + +V E + N + Sbjct: 82 GYTEKQRRDFLCEASIMGQF-DHPNVVHLEGVVTR--GKPVMIVIEFMENGALDAFLRKH 138 Query: 128 ---LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHP 184 T + + I + Y MG +HRD+ N++++ + ++ D+GL+ Sbjct: 139 DGQFTVIQLVGMLRGIAAGMRYLADMGYVHRDLAARNILVNS-NLVCKVSDFGLSRVIED 197 Query: 185 GQE--YNVRVA--SRYFKGPELLVDYQMYDYSLDMWSLGCMLAS-MIFRKEPFFHGHDNY 239 E Y + PE + Y+ + + D+WS G ++ M + + P++ N Sbjct: 198 DPEAVYTTTGGKIPVRWTAPEAIQ-YRKFTSASDVWSYGIVMWEVMSYGERPYWD-MSNQ 255 Query: 240 DQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALD 299 D + I + Y + L + W++ + + + Sbjct: 256 DVIKAIEEG------------YRLPAPMDCPAGLHQLMLDCWQK---ERAERPKFEQIVG 300 Query: 300 FLDKLLRYDHQ 310 LDK++R + Sbjct: 301 ILDKMIR-NPN 310 >4UY9-A nrPDB Length = 323 Score = 191 bits (485), Expect = 6e-49, Method: Composition-based stats. Identities = 59/286 (20%), Positives = 114/286 (39%), Gaps = 44/286 (15%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKI-------KREIKILENLRG 90 + L +G G + +V+ A I ++V VK + + I ++E K+ L+ Sbjct: 10 ELTLEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKH 67 Query: 91 GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY--QTLTDYDIRFYMYEILKALDYCH 148 PNII L + LV E ++ + + + + +I + ++Y H Sbjct: 68 -PNIIALRGVCLKEP--NLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLH 124 Query: 149 SMGI---MHRDVKPHNVMI-------DHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFK 198 I +HRD+K N++I D ++ L++ D+GLA +H + + + + Sbjct: 125 DEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSA-AGTYAWM 183 Query: 199 GPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYI 258 PE++ M+ D+WS G +L ++ + PF G D +A + Sbjct: 184 APEVIR-ASMFSKGSDVWSYGVLLWELLTGEVPF-RGIDGLAVAYGVA-----------M 230 Query: 259 DKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKL 304 +K + + + + W HS P + LD+L Sbjct: 231 NKLALPIPSTCPEPFAKLMEDCWNPDPHSR------PSFTNILDQL 270 >3V5Q-A nrPDB Length = 297 Score = 190 bits (484), Expect = 6e-49, Method: Composition-based stats. Identities = 59/315 (18%), Positives = 114/315 (36%), Gaps = 73/315 (23%) Query: 35 NQDDYQLVRKLGRGKYSEVFEAIN-----ITNNEKVVVKILKP---VKKKKIKREIKILE 86 + D L R+LG G + +VF A + V VK LK +K +RE ++L Sbjct: 13 KRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLT 72 Query: 87 NLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT------------------- 127 NL+ +I+ + D +VFE++ + D + + Sbjct: 73 NLQH-EHIVKFYGVCGD--GDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGE 129 Query: 128 LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE 187 L + +I + Y S +HRD+ N ++ + +++ D+G++ + Sbjct: 130 LGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGA-NLLVKIGDFGMSRDVYSTDY 188 Query: 188 YNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIF-RKEPFFHGHDNYDQLV 243 Y V + + PE ++ Y+ + D+WS G +L + K+P+F Sbjct: 189 YRVGGHTMLPIRWMPPESIM-YRKFTTESDVWSFGVILWEIFTYGKQPWFQ--------- 238 Query: 244 RIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDK 303 L ++ + I + + PR + E D + Sbjct: 239 -----LSNTEVIECITQGRVLERPR-----------------------VCPKEVYDVMLG 270 Query: 304 LLRYDHQSRLTAREA 318 + + Q RL +E Sbjct: 271 CWQREPQQRLNIKEI 285 >4EBW-A nrPDB Length = 304 Score = 190 bits (483), Expect = 8e-49, Method: Composition-based stats. Identities = 52/265 (19%), Positives = 107/265 (40%), Gaps = 29/265 (10%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEK---VVVKILKPVK----KKKIKREIKILENL 88 ++ +L R +G G++ +V + I ++ V +K K ++K +E + Sbjct: 37 RERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQF 96 Query: 89 RGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ----TLTDYDIRFYMYEILKAL 144 P+I+ L ++ + ++ E + + Q +L + Y Y++ AL Sbjct: 97 -DHPHIVKLIGVITE---NPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTAL 152 Query: 145 DYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY--FKGPEL 202 Y S +HRD+ NV++ + ++L D+GL+ + Y + PE Sbjct: 153 AYLESKRFVHRDIAARNVLVSS-NDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPES 211 Query: 203 LVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVL-------GTEDLY 255 + +++ + + D+W G + ++ F G N D + RI LY Sbjct: 212 I-NFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLY 270 Query: 256 DYIDK---YNIELDPRFNDILGRHS 277 + K Y+ PRF ++ + S Sbjct: 271 SLMTKCWAYDPSRRPRFTELKAQLS 295 >2W1I-A nrPDB Length = 326 Score = 190 bits (483), Expect = 8e-49, Method: Composition-based stats. Identities = 45/217 (20%), Positives = 97/217 (44%), Gaps = 18/217 (8%) Query: 26 YESHVVEWGNQDDYQLVRKLGRGKYSEVFEAI----NITNNEKVVVKILKPVKKK---KI 78 +E + + +++LG+G + V E V VK L+ ++ Sbjct: 30 FEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDF 89 Query: 79 KREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDY----DIR 134 +REI+IL++L+ NI+ + R L+ E++ + Q + + Sbjct: 90 EREIEILKSLQHD-NIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLL 148 Query: 135 FYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVR--- 191 Y +I K ++Y + +HRD+ N+++++E+R +++ D+GL + +EY Sbjct: 149 QYTSQICKGMEYLGTKRYIHRDLATRNILVENENR-VKIGDFGLTKVLPQDKEYYKVKEP 207 Query: 192 -VASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIF 227 + ++ PE L + + + + D+WS G +L + Sbjct: 208 GESPIFWYAPESLTESK-FSVASDVWSFGVVLYELFT 243 >2FO0-A nrPDB Length = 495 Score = 190 bits (483), Expect = 9e-49, Method: Composition-based stats. Identities = 55/343 (16%), Positives = 126/343 (36%), Gaps = 63/343 (18%) Query: 4 PVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNE 63 P P R + + + W+ E + D + KLG G+Y EV+E + + Sbjct: 193 PAPKRNKPTVYGVSPN-YDKWEME--------RTDITMKHKLGGGQYGEVYEGVWKKYSL 243 Query: 64 KVVVKILK--PVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDF 121 V VK LK ++ ++ +E +++ ++ PN++ L + ++ E + + Sbjct: 244 TVAVKTLKEDTMEVEEFLKEAAVMKEIKH-PNLVQLLGVCTREP--PFYIITEFMTYGNL 300 Query: 122 KQLYQTLTDYDI-----RFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDW 176 + ++ + +I A++Y +HR++ N ++ E+ +++ D+ Sbjct: 301 LDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRNLAARNCLVG-ENHLVKVADF 359 Query: 177 GLAEFYHPGQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFF 233 GL+ G Y +++ + PE L Y + D+W+ G +L + + Sbjct: 360 GLSRLM-TGDTYTAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSPY 417 Query: 234 HGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLV 293 G D L ++ ++L E+ E Sbjct: 418 PGID----LSQVYELL--------------------------------EKDYRMERPEGC 441 Query: 294 SPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGS 336 + + + +++ R + E H F T+ ++ + Sbjct: 442 PEKVYELMRACWQWNPSDRPSFAEI--HQAFETMFQESSISDE 482 >3LLT-A nrPDB Length = 360 Score = 190 bits (483), Expect = 9e-49, Method: Composition-based stats. Identities = 70/330 (21%), Positives = 135/330 (40%), Gaps = 49/330 (14%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK--KKIKREIKILENLRGGPNI-- 94 + ++RK+G G + V +I N + VK+++ +KK + K E IL+ ++ Sbjct: 37 FLVIRKMGDGTFGRVLLCQHIDNKKYYAVKVVRNIKKYTRSAKIEADILKKIQNDDINNN 96 Query: 95 --ITLADIVKDPVSRTPALVFEHVNNTDFKQL----YQTLTDYDIRFYMYEILKALDYCH 148 + L+FE + + ++ + Y DI+ Y EILKAL+Y Sbjct: 97 NIVKYHGKF--MYYDHMCLIFEPLGPSLYEIITRNNYNGFHIEDIKLYCIEILKALNYLR 154 Query: 149 SMGIMHRDVKPHNVMID------------------------HEHRKLRLIDWGLAEFYHP 184 M + H D+KP N+++D + ++LID+G A F Sbjct: 155 KMSLTHTDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRTKSTGIKLIDFGCATFKSD 214 Query: 185 GQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVR 244 + + +R ++ PE++++ +D S DMWS GC+LA + F H++ + L Sbjct: 215 --YHGSIINTRQYRAPEVILNL-GWDVSSDMWSFGCVLAELYTGSL-LFRTHEHMEHLAM 270 Query: 245 IAKVLGTED---LYDYIDKYNI------ELDPRFNDILGRHSRKRWERFVHSENQHLVSP 295 + ++ LY+ EL + + + + + + + Sbjct: 271 MESIIQPIPKNMLYEATKTNGSKYVNKDELKLAWPENASSINSIKHVKKCLPLYKIIKHE 330 Query: 296 EALDFLDKLLRYDHQSRLTAREAMEHPYFY 325 DFL +L+ D R + E ++H + Sbjct: 331 LFCDFLYSILQIDPTLRPSPAELLKHKFLE 360 >6NPU-A nrPDB Length = 298 Score = 190 bits (483), Expect = 9e-49, Method: Composition-based stats. Identities = 51/311 (16%), Positives = 117/311 (37%), Gaps = 54/311 (17%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK--PVKKKKIKREIKILENLRGGPN 93 + D + KLG G+Y EV+E + + V VK LK ++ ++ +E +++ ++ PN Sbjct: 25 RTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKH-PN 83 Query: 94 IITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDI-----RFYMYEILKALDYCH 148 ++ L + ++ E + + + ++ + +I A++Y Sbjct: 84 LVQLLGVCTREP--PFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLE 141 Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLVD 205 +HRD+ N ++ E+ +++ D+GL+ G Y +++ + PE L Sbjct: 142 KKNFIHRDLAARNCLVG-ENHLVKVADFGLSRLM-TGDTYTAHAGAKFPIKWTAPESLA- 198 Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIEL 265 Y + D+W+ G +L + + G D L ++ ++L Sbjct: 199 YNKFSIKSDVWAFGVLLWEIATYGMSPYPGID----LSQVYELL---------------- 238 Query: 266 DPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFY 325 E+ E + + + +++ R + E H F Sbjct: 239 ----------------EKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEI--HQAFE 280 Query: 326 TVVKDQARMGS 336 T+ ++ + Sbjct: 281 TMFQESSISDE 291 >4E93-A nrPDB Length = 377 Score = 189 bits (481), Expect = 1e-48, Method: Composition-based stats. Identities = 65/299 (21%), Positives = 109/299 (36%), Gaps = 38/299 (12%) Query: 4 PVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNE 63 P+ ++ V ++ P++ W N +D L ++GRG + EVF +N Sbjct: 91 PLTKKSGVV--LHRAVPKDKW--------VLNHEDLVLGEQIGRGNFGEVFSGRLRADNT 140 Query: 64 KVVVK----ILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNT 119 V VK L P K K +E +IL+ PNI+ L + + +V E V Sbjct: 141 LVAVKSCRETLPPDLKAKFLQEARILKQYSH-PNIVRLIGVCTQK--QPIYIVMELVQGG 197 Query: 120 DFKQLYQT----LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLID 175 DF +T L + + + ++Y S +HRD+ N ++ ++ L++ D Sbjct: 198 DFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKN-VLKISD 256 Query: 176 WGLAEFYHPGQEYNVRVASRY----FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEP 231 +G++ G Y R + PE L +Y Y D+WS G +L Sbjct: 257 FGMSREEADG-VYAASGGLRQVPVKWTAPEAL-NYGRYSSESDVWSFGILLWETFSLGAS 314 Query: 232 FFHGHDNYDQLVRIAKVLGTE----------DLYDYIDKYNIELDPRFNDILGRHSRKR 280 + N + K L + Y P F+ I R Sbjct: 315 PYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIR 373 >3PPZ-A nrPDB Length = 309 Score = 189 bits (481), Expect = 1e-48, Method: Composition-based stats. Identities = 60/276 (21%), Positives = 114/276 (41%), Gaps = 28/276 (10%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK-----KKKIKREIKILENLRGGP 92 D + K+G G + V A + V VKIL + RE+ I++ LR P Sbjct: 38 DLNIKEKIGAGSFGTVHRAEW--HGSDVAVKILMEQDFHAERVNEFLREVAIMKRLRH-P 94 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT------LTDYDIRFYMYEILKALDY 146 NI+ V P ++V E+++ +L L + Y++ K ++Y Sbjct: 95 NIVLFMGAVTQPP--NLSIVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAKGMNY 152 Query: 147 CHSMG--IMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ-EYNVRVASRYFKGPELL 203 H+ I+HRD+K N+++D + +++ D+GL+ + + PE+L Sbjct: 153 LHNRNPPIVHRDLKSPNLLVDKK-YTVKVCDFGLSRLKASTFLSSKSAAGTPEWMAPEVL 211 Query: 204 VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNI 263 D + D++S G +L + ++P+ G+ N Q+ +A V + N Sbjct: 212 RDEPS-NEKSDVYSFGVILWELATLQQPW--GNLNPAQV--VAAVGFKCKRLEIPRNLNP 266 Query: 264 ELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALD 299 ++ I G + + W+R + L+ P Sbjct: 267 QVA---AIIEGCWTNEPWKRPSFATIMDLLRPLIKS 299 >3DTC-A nrPDB Length = 271 Score = 189 bits (481), Expect = 2e-48, Method: Composition-based stats. Identities = 59/286 (20%), Positives = 114/286 (39%), Gaps = 44/286 (15%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKI-------KREIKILENLRG 90 + L +G G + +V+ A I ++V VK + + I ++E K+ L+ Sbjct: 8 ELTLEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKH 65 Query: 91 GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY--QTLTDYDIRFYMYEILKALDYCH 148 PNII L + LV E ++ + + + + +I + ++Y H Sbjct: 66 -PNIIALRGVCLKEP--NLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLH 122 Query: 149 SMGI---MHRDVKPHNVMI-------DHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFK 198 I +HRD+K N++I D ++ L++ D+GLA +H + + + + Sbjct: 123 DEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSA-AGAYAWM 181 Query: 199 GPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYI 258 PE++ M+ D+WS G +L ++ + PF G D +A + Sbjct: 182 APEVIR-ASMFSKGSDVWSYGVLLWELLTGEVPF-RGIDGLAVAYGVA-----------M 228 Query: 259 DKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKL 304 +K + + + + W HS P + LD+L Sbjct: 229 NKLALPIPSTCPEPFAKLMEDCWNPDPHSR------PSFTNILDQL 268 >4H1J-A nrPDB Length = 293 Score = 189 bits (480), Expect = 2e-48, Method: Composition-based stats. Identities = 60/265 (22%), Positives = 115/265 (43%), Gaps = 29/265 (10%) Query: 36 QDDYQLVRKLGRGKYSEVFEAI---NITNNEKVVVKILKPV----KKKKIKREIKILENL 88 ++D L R LG G + EV+E + + V VK K K+K E I++NL Sbjct: 23 REDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNL 82 Query: 89 RGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ----TLTDYDIRFYMYEILKAL 144 P+I+ L I+++ + ++ E + + +L + Y +I KA+ Sbjct: 83 -DHPHIVKLIGIIEEEPT---WIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAM 138 Query: 145 DYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY--FKGPEL 202 Y S+ +HRD+ N+++ ++L D+GL+ + Y V + PE Sbjct: 139 AYLESINCVHRDIAVRNILVASPEC-VKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPES 197 Query: 203 LVDYQMYDYSLDMWSLGCMLASMI-FRKEPFF--HGHDNYDQLVRIAKV----LGTEDLY 255 + +++ + + D+W + ++ F K+PFF D L + ++ L LY Sbjct: 198 I-NFRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLY 256 Query: 256 DYIDK---YNIELDPRFNDILGRHS 277 + + Y+ PRF +++ S Sbjct: 257 TLMTRCWDYDPSDRPRFTELVCSLS 281 >2J0K-A nrPDB Length = 656 Score = 189 bits (480), Expect = 2e-48, Method: Composition-based stats. Identities = 52/265 (19%), Positives = 106/265 (40%), Gaps = 29/265 (10%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNN---EKVVVKILKPVK----KKKIKREIKILENL 88 ++ +L R +G G++ +V + I ++ V +K K ++K +E + Sbjct: 389 RERIELGRCIGEGQFGDVHQGIYMSPENPAMAVAIKTCKNCTSDSVREKFLQEALTMRQF 448 Query: 89 RGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ----TLTDYDIRFYMYEILKAL 144 P+I+ L ++ + ++ E + + Q +L + Y Y++ AL Sbjct: 449 -DHPHIVKLIGVITE---NPVWIIMELCTLGELRSFLQVRKFSLDLASLILYAYQLSTAL 504 Query: 145 DYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY--FKGPEL 202 Y S +HRD+ NV++ ++L D+GL+ + Y + PE Sbjct: 505 AYLESKRFVHRDIAARNVLVSATDC-VKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPES 563 Query: 203 LVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVL-------GTEDLY 255 + +++ + + D+W G + ++ F G N D + RI LY Sbjct: 564 I-NFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLY 622 Query: 256 DYIDK---YNIELDPRFNDILGRHS 277 + K Y+ PRF ++ + S Sbjct: 623 SLMTKCWAYDPSRRPRFTELKAQLS 647 >4X7Q-B nrPDB Length = 312 Score = 189 bits (479), Expect = 3e-48, Method: Composition-based stats. Identities = 68/323 (21%), Positives = 118/323 (36%), Gaps = 63/323 (19%) Query: 34 GNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP---------VKKKKIKREIKI 84 + +Y+L LG+G + VF +T+ +V +K++ E+ + Sbjct: 28 AFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVAL 87 Query: 85 LENLR---GGPNIITLADIVKDPVSRTPALVFEH-VNNTDFKQLY---QTLTDYDIRFYM 137 L + G P +I L D + LV E + D L + R + Sbjct: 88 LWKVGAGGGHPGVIRLLDWFE--TQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFF 145 Query: 138 YEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYF 197 +++ A+ +CHS G++HRD+K N++ID +LID+G H + Y +R + Sbjct: 146 GQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHD-EPYTDFDGTRVY 204 Query: 198 KGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDY 257 PE + +Q + +WSLG +L M+ PF R ++L E + Sbjct: 205 SPPEWISRHQYHALPATVWSLGILLYDMVCGDIPF----------ERDQEILEAELHFPA 254 Query: 258 IDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTARE 317 VSP+ + + L SR + E Sbjct: 255 H----------------------------------VSPDCCALIRRCLAPKPSSRPSLEE 280 Query: 318 AMEHPYFYTVVKDQARMGSSSMP 340 + P+ T +D S P Sbjct: 281 ILLDPWMQTPAEDVPLNPSKGGP 303 >3TT0-A nrPDB Length = 382 Score = 189 bits (479), Expect = 3e-48, Method: Composition-based stats. Identities = 50/275 (18%), Positives = 109/275 (39%), Gaps = 37/275 (13%) Query: 36 QDDYQLVRKLGRGKYSEVFEA------INITNN-EKVVVKILKPVKKKK----IKREIKI 84 +D L + LG G + +V A + N KV VK+LK +K + E+++ Sbjct: 68 RDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEM 127 Query: 85 LENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----------------- 127 ++ + NII L ++ E+ + + ++ Q Sbjct: 128 MKMIGKHKNIINLLGACTQ--DGPLYVIVEYASKGNLREYLQARRPPGLEYSYNPSHNPE 185 Query: 128 --LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPG 185 L+ D+ Y++ + ++Y S +HRD+ NV++ ++ +++ D+GLA H Sbjct: 186 EQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDN-VMKIADFGLARDIHHI 244 Query: 186 QEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQL 242 Y R + PE L D ++Y + D+WS G +L + + G + Sbjct: 245 DYYKKTTNGRLPVKWMAPEALFD-RIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELF 303 Query: 243 VRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHS 277 + + + + ++ + + ++ + + Sbjct: 304 KLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRP 338 >3PP0-A nrPDB Length = 338 Score = 188 bits (478), Expect = 4e-48, Method: Composition-based stats. Identities = 71/312 (22%), Positives = 134/312 (42%), Gaps = 35/312 (11%) Query: 35 NQDDYQLVRKLGRGKYSEVFEAINITNNEKV----VVKILK----PVKKKKIKREIKILE 86 + + + V+ LG G + V++ I I + E V +K+L+ P K+I E ++ Sbjct: 15 KETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMA 74 Query: 87 NLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ----TLTDYDIRFYMYEILK 142 + G P + L I ++ T LV + + + L D+ + +I K Sbjct: 75 GV-GSPYVSRLLGIC---LTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAK 130 Query: 143 ALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ-EYNVRVASRY--FKG 199 + Y + ++HRD+ NV++ + +++ D+GLA + EY+ + Sbjct: 131 GMSYLEDVRLVHRDLAARNVLVKSPNH-VKITDFGLARLLDIDETEYHADGGKVPIKWMA 189 Query: 200 PELLVDYQMYDYSLDMWSLGCMLAS-MIFRKEPF--FHGHDNYDQLVRIAKV----LGTE 252 E ++ + + + D+WS G + M F +P+ + D L + ++ + T Sbjct: 190 LESIL-RRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTI 248 Query: 253 DLYDYIDKYNI---ELDPRFNDILGRHSR--KRWERFVHSENQHLVSPEALD--FLDKLL 305 D+Y + K + E PRF +++ SR + +RFV +N+ L LD F LL Sbjct: 249 DVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLL 308 Query: 306 RYDHQSRLTARE 317 D L E Sbjct: 309 EDDDMGDLVDAE 320 >4AT3-A nrPDB Length = 299 Score = 188 bits (477), Expect = 4e-48, Method: Composition-based stats. Identities = 61/297 (20%), Positives = 115/297 (38%), Gaps = 39/297 (13%) Query: 35 NQDDYQLVRKLGRGKYSEVFEAINIT-----NNEKVVVKILKPVK---KKKIKREIKILE 86 + + L R+LG G + +VF A + V VK LK +K RE ++L Sbjct: 11 KRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLT 70 Query: 87 NLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----------------LTD 130 NL+ +I+ + + +VFE++ + D + + LT Sbjct: 71 NLQH-EHIVKFYGVCVE--GDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQ 127 Query: 131 YDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNV 190 + +I + Y S +HRD+ N ++ E+ +++ D+G++ + Y V Sbjct: 128 SQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVG-ENLLVKIGDFGMSRDVYSTDYYRV 186 Query: 191 RVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIF-RKEPFFHGHDNYDQLVRIA 246 + + PE ++ Y+ + D+WSLG +L + K+P++ +N + + I Sbjct: 187 GGHTMLPIRWMPPESIM-YRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNN-EVIECIT 244 Query: 247 --KVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFL 301 +VL + EL + +N SP LD L Sbjct: 245 QGRVLQRPRT---CPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDIL 298 >4C59-A nrPDB Length = 340 Score = 188 bits (477), Expect = 4e-48, Method: Composition-based stats. Identities = 58/329 (17%), Positives = 125/329 (37%), Gaps = 73/329 (22%) Query: 21 REYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL---KPVKKKK 77 R+ D+ VE G + ++ R L G ++ V+EA ++ + + +K L + K + Sbjct: 12 RDQSDFVGQTVELG-ELRLRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRA 70 Query: 78 IKREIKILENLRGGPNIITL-----ADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTD-- 130 I +E+ ++ L G PNI+ + + L+ + + + + Sbjct: 71 IIQEVCFMKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRG 130 Query: 131 ----YDIRFYMYEILKALDYCHSMG--IMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHP 184 + Y+ +A+ + H I+HRD+K N+++ ++ ++L D+G A Sbjct: 131 PLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQG-TIKLCDFGSATTISH 189 Query: 185 GQEYN-------------VRVASRYFKGPELLVDYQMY--DYSLDMWSLGCMLASMIFRK 229 +Y+ R + ++ PE++ Y + D+W+LGC+L + FR+ Sbjct: 190 YPDYSWSAQRRALVEEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQ 249 Query: 230 EPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSEN 289 PF G ++ V G + + +Y + Sbjct: 250 HPFEDG-------AKLRIVNGKYSIPPHDTQYTV-------------------------- 276 Query: 290 QHLVSPEALDFLDKLLRYDHQSRLTAREA 318 + +L+ + + RL+ E Sbjct: 277 -------FHSLIRAMLQVNPEERLSIAEV 298 >3BBT-B nrPDB Length = 328 Score = 187 bits (476), Expect = 5e-48, Method: Composition-based stats. Identities = 61/301 (20%), Positives = 121/301 (40%), Gaps = 36/301 (11%) Query: 35 NQDDYQLVRKLGRGKYSEVFEAINITNNEKV----VVKILK----PVKKKKIKREIKILE 86 + + + V+ LG G + V++ I + E V +KIL P + E I+ Sbjct: 13 KETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMA 72 Query: 87 NLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----LTDYDIRFYMYEILK 142 + P+++ L + P T LV + + + + + + + +I K Sbjct: 73 S-MDHPHLVRLLGVCLSP---TIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAK 128 Query: 143 ALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH-PGQEYNVRVASRY--FKG 199 + Y ++HRD+ NV++ + +++ D+GLA +EYN + Sbjct: 129 GMMYLEERRLVHRDLAARNVLVKSPNH-VKITDFGLARLLEGDEKEYNADGGKMPIKWMA 187 Query: 200 PELLVDYQMYDYSLDMWSLGCMLAS-MIFRKEPF--FHGHDNYDQLVRIAKV----LGTE 252 E + Y+ + + D+WS G + M F +P+ + D L + ++ + T Sbjct: 188 LECI-HYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTI 246 Query: 253 DLYDYIDKYNI---ELDPRFNDILGRHSR-----KRWERFVHSENQHLVSPEALDFLDKL 304 D+Y + K + + P+F ++ SR +R+ + L SP F L Sbjct: 247 DVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNL 306 Query: 305 L 305 L Sbjct: 307 L 307 >5A46-A nrPDB Length = 386 Score = 187 bits (475), Expect = 7e-48, Method: Composition-based stats. Identities = 56/309 (18%), Positives = 119/309 (38%), Gaps = 38/309 (12%) Query: 36 QDDYQLVRKLGRGKYSEVFEA------INITNN-EKVVVKILKPVKKKK----IKREIKI 84 +D L + LG G + +V A + N KV VK+LK +K + E+++ Sbjct: 39 RDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEM 98 Query: 85 LENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----------------- 127 ++ + NII L ++ E+ + + ++ Q Sbjct: 99 MKMIGKHKNIINLLGACTQ--DGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPE 156 Query: 128 --LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPG 185 L+ D+ Y++ + ++Y S +HRD+ NV++ ++ +++ D+GLA H Sbjct: 157 EQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDN-VMKIADFGLARDIHHI 215 Query: 186 QEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQL 242 Y R + PE L D ++Y + D+WS G +L + + G + Sbjct: 216 DYYKKTTNGRLPVKWMAPEALFD-RIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELF 274 Query: 243 VRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSR-KRWERFVHSENQHLVSPEALDFL 301 + + + + ++ + + ++ + + K+ + + E LD Sbjct: 275 KLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLS 334 Query: 302 DKLLRYDHQ 310 L +Y Sbjct: 335 MPLDQYSPS 343 >3GQL-A nrPDB Length = 326 Score = 187 bits (475), Expect = 7e-48, Method: Composition-based stats. Identities = 54/299 (18%), Positives = 116/299 (38%), Gaps = 38/299 (12%) Query: 36 QDDYQLVRKLGRGKYSEVFEA------INITNN-EKVVVKILKPVKKKK----IKREIKI 84 +D L + LG G + +V A + N KV VK+LK +K + E+++ Sbjct: 27 RDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEM 86 Query: 85 LENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----------------- 127 ++ + NII L ++ E+ + + ++ Q Sbjct: 87 MKMIGKHKNIINLLGACTQ--DGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPE 144 Query: 128 --LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPG 185 L+ D+ Y++ + ++Y S +HRD+ NV++ ++ +++ D+GLA H Sbjct: 145 EQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDN-VMKIADFGLARDIHHI 203 Query: 186 QEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQL 242 Y R + PE L D ++Y + D+WS G +L + + G + Sbjct: 204 DYYKKTTNGRLPVKWMAPEALFD-RIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELF 262 Query: 243 VRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSR-KRWERFVHSENQHLVSPEALDF 300 + + + + ++ + + ++ + + K+ + + E LD Sbjct: 263 KLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDL 321 >3ORP-A nrPDB Length = 311 Score = 187 bits (475), Expect = 7e-48, Method: Composition-based stats. Identities = 75/337 (22%), Positives = 134/337 (39%), Gaps = 62/337 (18%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK------PVKKKKIKREIKILENLRG 90 D Y+L LG G SEV A ++ ++ V VK+L+ P + +RE + L Sbjct: 12 DRYELGEILGFGGMSEVHLARDLRDHRDVAVKVLRADLARDPSFYLRFRREAQNAAAL-N 70 Query: 91 GPNIITLADIVK--DPVSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALD 145 P I+ + D + P P +V E+V+ + + T +T + + +AL+ Sbjct: 71 HPAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIVHTEGPMTPKRAIEVIADACQALN 130 Query: 146 YCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVR----VASRYFKGPE 201 + H GI+HRDVKP N+MI + ++++D+G+A + + + + PE Sbjct: 131 FSHQNGIIHRDVKPANIMISATN-AVKVMDFGIARAIADSGNSVTQTAAVIGTAQYLSPE 189 Query: 202 LLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKY 261 + D D++SLGC+L ++ + PF T D + Sbjct: 190 QARGDSV-DARSDVYSLGCVLYEVLTGEPPF------------------TGDSPVSVAYQ 230 Query: 262 NIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRL-TAREAME 320 ++ DP S +S + + K L + ++R TA E Sbjct: 231 HVREDP----------------IPPSARHEGLSADLDAVVLKALAKNPENRYQTAAE--- 271 Query: 321 HPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISS 357 + D R+ + P ++ A S +SS Sbjct: 272 ------MRADLVRVHNGEPPEAPKVLTDAERTSLLSS 302 >4UYA-A nrPDB Length = 340 Score = 187 bits (475), Expect = 8e-48, Method: Composition-based stats. Identities = 49/269 (18%), Positives = 110/269 (40%), Gaps = 38/269 (14%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK-------KKIKREIKILENLR 89 + +L +G G + +V+ A ++V VK + + + ++RE ++ LR Sbjct: 26 ERLELKELIGAGGFGQVYRATWQ--GQEVAVKAARQDPEQDAAAAAESVRREARLFAMLR 83 Query: 90 GGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY--QTLTDYDIRFYMYEILKALDYC 147 PNII L + LV E + + + + + + +I + + Y Sbjct: 84 H-PNIIELRGVCLQQP--HLCLVLEFARGGALNRALAGRRIPPHVLVNWAVQIARGMLYL 140 Query: 148 HSMG---IMHRDVKPHNVMIDHE-------HRKLRLIDWGLAEFYHPGQEYNVRVASRYF 197 H I+HRD+K N+++ + ++ L++ D+GLA +H + + + Sbjct: 141 HEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTKMAT-AGAYAW 199 Query: 198 KGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDY 257 PE++ ++ D+WS G +L ++ + P + G D +A Sbjct: 200 MAPEVI-KSSLFSKGSDIWSYGVLLWELLTGEVP-YRGIDGLAVAYGVA----------- 246 Query: 258 IDKYNIELDPRFNDILGRHSRKRWERFVH 286 ++K + + + + ++ W++ H Sbjct: 247 VNKLTLPIPSTCPEPFAKLMKECWQQDPH 275 >2HK5-A nrPDB Length = 270 Score = 187 bits (474), Expect = 8e-48, Method: Composition-based stats. Identities = 43/279 (15%), Positives = 111/279 (39%), Gaps = 23/279 (8%) Query: 21 REYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEA-INITNNEKVVVKILKP--VKKKK 77 ++ W+ ++ + ++ +L +KLG G++ EV+ A N KV VK +KP + + Sbjct: 2 QKPWEKDAWEIP---RESLKLEKKLGAGQFGEVWMATYNKHT--KVAVKTMKPGSMSVEA 56 Query: 78 IKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ-----TLTDYD 132 E +++ L+ ++ L +V ++ E + + Sbjct: 57 FLAEANVMKTLQHDK-LVKLHAVV---TKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPK 112 Query: 133 IRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRV 192 + + +I + + + +HRD++ N+++ ++ D+GLA EY R Sbjct: 113 LIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSA-SLVCKIADFGLARVIED-NEYTARE 170 Query: 193 ASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVL 249 +++ + PE + ++ + D+WS G +L ++ + G N + + + + Sbjct: 171 GAKFPIKWTAPEAI-NFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGY 229 Query: 250 GTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSE 288 + ++ + + + + + V + Sbjct: 230 RMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDD 268 >4P5Q-A nrPDB Length = 361 Score = 187 bits (474), Expect = 9e-48, Method: Composition-based stats. Identities = 62/306 (20%), Positives = 116/306 (37%), Gaps = 38/306 (12%) Query: 20 PREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEK---VVVKILKPVKKK 76 PR + + + + + +G G++ EV ++K V +K LK + Sbjct: 16 PRGSTQTVHEFAKELDATNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTE 75 Query: 77 KIKR----EIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----L 128 K +R E I+ PNII L +V S+ +V E++ N + Sbjct: 76 KQRRDFLGEASIMGQF-DHPNIIRLEGVVT--KSKPVMIVTEYMENGSLDSFLRKHDAQF 132 Query: 129 TDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE- 187 T + + I + Y MG +HRD+ N++I+ + ++ D+GL+ E Sbjct: 133 TVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINS-NLVCKVSDFGLSRVLEDDPEA 191 Query: 188 -YNVRVA--SRYFKGPELLVDYQMYDYSLDMWSLGCMLAS-MIFRKEPFFHGHDNYDQLV 243 Y R + PE + Y+ + + D+WS G +L M + + P++ N D + Sbjct: 192 AYTTRGGKIPIRWTSPEAIA-YRKFTSASDVWSYGIVLWEVMSYGERPYWE-MSNQDVIK 249 Query: 244 RIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDK 303 + + D L + W++ N + + LDK Sbjct: 250 AVDEGYRLPPPMD------------CPAALYQLMLDCWQK---DRNNRPKFEQIVSILDK 294 Query: 304 LLRYDH 309 L+R + Sbjct: 295 LIR-NP 299 >1FVR-A nrPDB Length = 327 Score = 187 bits (474), Expect = 9e-48, Method: Composition-based stats. Identities = 50/317 (15%), Positives = 109/317 (34%), Gaps = 68/317 (21%) Query: 28 SHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKV--VVKILKPVKKKKIKR----E 81 V++W +D + +G G + +V +A + ++ +K +K K R E Sbjct: 19 YPVLDW---NDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGE 75 Query: 82 IKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ--------------- 126 +++L L PNII L + L E+ + + + Sbjct: 76 LEVLCKLGHHPNIINLLGACEH--RGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIAN 133 Query: 127 ----TLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFY 182 TL+ + + ++ + +DY +HRD+ N+++ E+ ++ D+GL+ Sbjct: 134 STASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVG-ENYVAKIADFGLSRGQ 192 Query: 183 HPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQL 242 + + + E L +Y +Y + D+WS G +L ++ + G Sbjct: 193 EVYVKKTMGRLPVRWMAIESL-NYSVYTTNSDVWSYGVLLWEIVSLGGTPYCG------- 244 Query: 243 VRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLD 302 + +LY+ + + P E D + Sbjct: 245 ------MTCAELYEKLPQGYRLEKP-----------------------LNCDDEVYDLMR 275 Query: 303 KLLRYDHQSRLTAREAM 319 + R R + + + Sbjct: 276 QCWREKPYERPSFAQIL 292 >1JPA-A nrPDB Length = 312 Score = 187 bits (474), Expect = 9e-48, Method: Composition-based stats. Identities = 57/313 (18%), Positives = 117/313 (37%), Gaps = 43/313 (13%) Query: 19 RPREYWDYESHVVEWGNQDDY---QLVRKLGRGKYSEVFEAINITNNEK---VVVKILKP 72 P + D V E+ + D ++ + +G G++ EV ++ V +K LK Sbjct: 12 DPFTFEDPNEAVREFAKEIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKS 71 Query: 73 VKKKKIKR----EIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT- 127 +K +R E I+ PN+I L +V ++ E + N + Sbjct: 72 GYTEKQRRDFLSEASIMGQF-DHPNVIHLEGVVTKST--PVMIITEFMENGSLDSFLRQN 128 Query: 128 ---LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHP 184 T + + I + Y M +HRD+ N++++ + ++ D+GL+ F Sbjct: 129 DGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNS-NLVCKVSDFGLSRFLED 187 Query: 185 GQ---EYNVRVASR---YFKGPELLVDYQMYDYSLDMWSLGCMLAS-MIFRKEPFFHGHD 237 Y + + + PE + Y+ + + D+WS G ++ M + + P++ Sbjct: 188 DTSDPTYTSALGGKIPIRWTAPEAIQ-YRKFTSASDVWSYGIVMWEVMSYGERPYWD-MT 245 Query: 238 NYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEA 297 N D + I + D L + W++ N + Sbjct: 246 NQDVINAIEQDYRLPPPMD------------CPSALHQLMLDCWQK---DRNHRPKFGQI 290 Query: 298 LDFLDKLLRYDHQ 310 ++ LDK++R + Sbjct: 291 VNTLDKMIR-NPN 302 >3C1X-A nrPDB Length = 373 Score = 186 bits (472), Expect = 1e-47, Method: Composition-based stats. Identities = 61/294 (20%), Positives = 123/294 (41%), Gaps = 31/294 (10%) Query: 10 RVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEK---VV 66 V+ D++ P E HVV + +GRG + V+ + N+ K Sbjct: 63 TVHIDLSALNP-ELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCA 121 Query: 67 VKILKPV----KKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFK 122 VK L + + + E I+++ PN+++L I V ++ + D + Sbjct: 122 VKSLNRITDIGEVSQFLTEGIIMKDFSH-PNVLSLLGICLRSEGSPLV-VLPYMKHGDLR 179 Query: 123 QLYQTLTD----YDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGL 178 + T D+ + ++ K + + S +HRD+ N M+D E +++ D+GL Sbjct: 180 NFIRNETHNPTVKDLIGFGLQVAKGMKFLASKKFVHRDLAARNCMLD-EKFTVKVADFGL 238 Query: 179 AEFYHPGQ--EYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFF 233 A + + + + ++ + E L Q + D+WS G +L ++ R P + Sbjct: 239 ARDMYDKEFDSVHNKTGAKLPVKWMALESLQT-QKFTTKSDVWSFGVLLWELMTRGAPPY 297 Query: 234 HGHDNYD---QLVRIAKVLGTE----DLYDYIDKY---NIELDPRFNDILGRHS 277 + +D L++ ++L E LY+ + K E+ P F++++ R S Sbjct: 298 PDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRIS 351 >6HV0-A nrPDB Length = 416 Score = 185 bits (471), Expect = 2e-47, Method: Composition-based stats. Identities = 67/305 (21%), Positives = 122/305 (40%), Gaps = 60/305 (19%) Query: 44 KLGRGKYSE-VFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVK 102 LG G V+ + +N V VK + P RE+++L PN+I K Sbjct: 15 VLGHGAEGTIVYRG--MFDNRDVAVKRILPECFSFADREVQLLRESDEHPNVIRYFCTEK 72 Query: 103 DPVSRTPALVF------EHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRD 156 D + A+ E+V DF L + + + L + HS+ I+HRD Sbjct: 73 DRQFQYIAIELCAATLQEYVEQKDFAHLG-----LEPITLLQQTTSGLAHLHSLNIVHRD 127 Query: 157 VKPHNVMIDHEHRKLR----LIDWGLAEFYHPGQEYNVRV----ASRYFKGPELLVD--Y 206 +KPHN++I + + + D+GL + G+ R + + PE+L + Sbjct: 128 LKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCK 187 Query: 207 QMYDYSLDMWSLGCMLASMIF-RKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIEL 265 + Y++D++S GC+ +I PF L R A +L D + Sbjct: 188 ENPTYTVDIFSAGCVFYYVISEGSHPF------GKSLQRQANILLGACSLDCLH------ 235 Query: 266 DPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFY 325 + D++ A + ++K++ D Q R +A+ ++HP+F+ Sbjct: 236 PEKHEDVI-----------------------ARELIEKMIAMDPQKRPSAKHVLKHPFFW 272 Query: 326 TVVKD 330 ++ K Sbjct: 273 SLEKQ 277 >5GRN-A nrPDB Length = 356 Score = 185 bits (471), Expect = 2e-47, Method: Composition-based stats. Identities = 54/266 (20%), Positives = 100/266 (37%), Gaps = 53/266 (19%) Query: 11 VYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNE-----KV 65 +Y D W++ +D L R LG G + +V E + KV Sbjct: 28 IYVDPMQLPYDSRWEFP--------RDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKV 79 Query: 66 VVKILKPV----KKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDF 121 VK+LKP +K+ + E+KI+ +L NI+ L S ++ E+ D Sbjct: 80 AVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACT--KSGPIYIITEYCFYGDL 137 Query: 122 KQLYQT-----------------------------LTDYDIRFYMYEILKALDYCHSMGI 152 LT D+ + Y++ + +++ S Sbjct: 138 VNYLHKNRDSFLSHKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNC 197 Query: 153 MHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLVDYQMY 209 +HRD+ NV++ + + +++ D+GLA Y + ++ + PE + D +Y Sbjct: 198 VHRDLAARNVLL-AQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFD-NLY 255 Query: 210 DYSLDMWSLGCMLASMIFRKEPFFHG 235 D+WS G +L + + G Sbjct: 256 TTLSDVWSYGILLWEIFSLGGTPYPG 281 >5MJB-A nrPDB Length = 305 Score = 185 bits (471), Expect = 2e-47, Method: Composition-based stats. Identities = 57/307 (18%), Positives = 116/307 (37%), Gaps = 43/307 (14%) Query: 25 DYESHVVEWGNQDDY---QLVRKLGRGKYSEVFEAINITNNEK---VVVKILK----PVK 74 D V E+ + D ++ +G G++ EV++ ++ V +K LK + Sbjct: 11 DPNEAVREFAKEIDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQ 70 Query: 75 KKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----LTD 130 ++ E I+ NII L +V SR ++ E + N + T Sbjct: 71 RRDFLSEASIMGQF-DHRNIIRLEGVVT--KSRPVMIITEFMENCALDSFLRQNDGQFTV 127 Query: 131 YDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ---E 187 + + I + Y M +HRD+ N++++ + ++ D+GL+ + Sbjct: 128 IQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNS-NLVCKVSDFGLSRYLQDDTSDPT 186 Query: 188 YNVRVASR---YFKGPELLVDYQMYDYSLDMWSLGCMLAS-MIFRKEPFFHGHDNYDQLV 243 Y + + + PE + Y+ + + D+WS G ++ M F + P++ N D + Sbjct: 187 YTSSLGGKIPVRWTAPEAIA-YRKFTSASDVWSYGIVMWEVMSFGERPYWD-MSNQDVIN 244 Query: 244 RIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDK 303 I + D L + W++ N E ++ LDK Sbjct: 245 AIEQDYRLPPPMD------------CPAALHQLMLDCWQK---DRNSRPRFAEIVNTLDK 289 Query: 304 LLRYDHQ 310 ++R + Sbjct: 290 MIR-NPA 295 >2Y6O-A nrPDB Length = 291 Score = 185 bits (470), Expect = 3e-47, Method: Composition-based stats. Identities = 49/275 (17%), Positives = 110/275 (40%), Gaps = 24/275 (8%) Query: 40 QLVRKLGRGKYSEVFEAINITNNEK---VVVKILKP----VKKKKIKREIKILENLRGGP 92 ++ + +G G++ EV ++ V +K LK +++ E I+ P Sbjct: 17 KIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQF-DHP 75 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----LTDYDIRFYMYEILKALDYCH 148 NII L +V + ++ E++ N + T + + I + Y Sbjct: 76 NIIHLEGVVT--KCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYLS 133 Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE--YNVRVA--SRYFKGPELLV 204 M +HRD+ N++++ + ++ D+G++ E Y R + PE + Sbjct: 134 DMSYVHRDLAARNILVNS-NLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIA 192 Query: 205 DYQMYDYSLDMWSLGCMLAS-MIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNI 263 Y+ + + D+WS G ++ M + + P++ N D + I + D + Sbjct: 193 -YRKFTSASDVWSYGIVMWEVMSYGERPYWD-MSNQDVIKAIEEGYRLPPPMDCPIALHQ 250 Query: 264 ELDPRFNDILGRHSRKRWERFVHSENQHLVSPEAL 298 + + R R ++ + V+ ++ + +P +L Sbjct: 251 LMLDCWQK--ERSDRPKFGQIVNMLDKLIRNPNSL 283 >5L6P-A nrPDB Length = 298 Score = 185 bits (470), Expect = 3e-47, Method: Composition-based stats. Identities = 55/298 (18%), Positives = 120/298 (40%), Gaps = 29/298 (9%) Query: 25 DYESHVVEWGNQDDY---QLVRKLGRGKYSEVFEAINITNNEK---VVVKILKPVKKKKI 78 D V E+ + D ++ +G G++ EV + V +K LK ++ Sbjct: 4 DPNEAVREFAKEIDVSCVKIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQ 63 Query: 79 KR----EIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ----TLTD 130 +R E I+ PNII L +V SR ++ E + N + T Sbjct: 64 RRDFLSEASIMGQF-DHPNIIRLEGVVT--KSRPVMILTEFMENCALDSFLRLNDGQFTV 120 Query: 131 YDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHP---GQE 187 + + I + Y M +HRD+ N++++ + ++ D+GL+ F Sbjct: 121 IQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNS-NLVCKVSDFGLSRFLEDDPSDPT 179 Query: 188 YNVRVASR---YFKGPELLVDYQMYDYSLDMWSLGCMLAS-MIFRKEPFFHGHDNYDQLV 243 Y + + + PE + Y+ + + D+WS G ++ M + + P++ N D + Sbjct: 180 YTSSLGGKIPIRWTAPEAIA-YRKFTSASDVWSYGIVMWEVMSYGERPYWD-MSNQDVIN 237 Query: 244 RIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFL 301 + + D + + + + R+ R ++ + V++ ++ + +P +L + Sbjct: 238 AVEQDYRLPPPMDCPTALHQLMLDCW--VRDRNLRPKFSQIVNTLDKLIRNPASLKVI 293 >4JLC-A nrPDB Length = 657 Score = 185 bits (470), Expect = 3e-47, Method: Composition-based stats. Identities = 65/349 (18%), Positives = 132/349 (37%), Gaps = 61/349 (17%) Query: 41 LVRKLGRGKYSEVFEAINITNNEKVVVKI------LKPVKKKKIKREIKILENLRGGPNI 94 L LG+G + VF + + VK+ L+PV + RE ++L+ L NI Sbjct: 12 LSDILGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQ--MREFEVLKKL-NHKNI 68 Query: 95 ITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT------LTDYDIRFYMYEILKALDYCH 148 + L I ++ +R L+ E + + L + + + +++ +++ Sbjct: 69 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 128 Query: 149 SMGIMHRDVKPHNVM--IDHEHRKL-RLIDWGLAEFYHPGQEYNVRVASRYFKGPELLV- 204 GI+HRD+KP N+M I + + + +L D+G A +++ + + P++ Sbjct: 129 ENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYER 188 Query: 205 ------DYQMYDYSLDMWSLGCMLASMIFRKEPFFH---GHDNYDQLVRIA------KVL 249 + Y ++D+WS+G PF N + + +I + Sbjct: 189 AVLRKDHQKKYGATVDLWSVGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAIS 248 Query: 250 GTEDLYDYIDKYNIELD--------------PRFNDILGRHSRKRWERFVHSENQHLVSP 295 G + + ++ ++ P +IL K W Sbjct: 249 GVQKAENGPIDWSGDMPLSCSLSQGLQALLTPVLANILEADQEKCWG-------FDQFFA 301 Query: 296 EALDFLDKL-LRYDHQSRLTAREAMEHPY-----FYTVVKDQARMGSSS 338 E D L ++ + +TA + H Y F+ +V Q ++ SS+ Sbjct: 302 ETSDVLHRMVIHVFSLQHMTAHKIYIHSYNTAAVFHELVYKQTKIVSSN 350 >5HLW-A nrPDB Length = 299 Score = 185 bits (470), Expect = 3e-47, Method: Composition-based stats. Identities = 62/283 (21%), Positives = 117/283 (41%), Gaps = 30/283 (10%) Query: 21 REYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEK---VVVKILKPV---- 73 E HVV + +GRG + V+ + N+ K VK L + Sbjct: 4 PELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIG 63 Query: 74 KKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTD--- 130 + + E I+++ PN+++L I V ++ + D + + T Sbjct: 64 EVSQFLTEGIIMKDFSH-PNVLSLLGICLRSEGSPLV-VLPYMKHGDLRNFIRNETHNPT 121 Query: 131 -YDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYN 189 D+ + ++ K + Y S +HRD+ N M+D E +++ D+GLA H + Y+ Sbjct: 122 VKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLD-EKFTVKVADFGLARDMHDKEYYS 180 Query: 190 VRVAS-----RYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYD---Q 241 V + + E L Q + D+WS G +L ++ R P + + +D Sbjct: 181 VHNKTGAKLPVKWMALESLQT-QKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVY 239 Query: 242 LVRIAKVLGTE----DLYDYIDKY---NIELDPRFNDILGRHS 277 L++ ++L E LY+ + K E+ P F++++ R S Sbjct: 240 LLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRIS 282 >4PL5-B nrPDB Length = 435 Score = 185 bits (469), Expect = 3e-47, Method: Composition-based stats. Identities = 70/328 (21%), Positives = 135/328 (41%), Gaps = 61/328 (18%) Query: 21 REYWDYESHVVEWGNQDDYQLVRKLGRGKYSE-VFEAINITNNEKVVVKILKPVKKKKIK 79 ++ D E+ +V G + LG G V++ + +N V VK + P Sbjct: 12 QDDEDEETRMVIVGKIS-FCPKDVLGHGAEGTIVYKG--MFDNRDVAVKRILPECFSFAD 68 Query: 80 REIKILENLRGGPNIITLADIVKDPVSRTPALVF------EHVNNTDFKQLYQTLTDYDI 133 RE+++L PN+I KD + A+ E+V DF L + Sbjct: 69 REVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLG-----LEP 123 Query: 134 RFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEH--RKLR--LIDWGLAEFYHPGQEYN 189 +++ L + HS+ I+HRD+KPHN+++ + +++ + D+GL + G+ Sbjct: 124 ITLLHQTTSGLAHLHSLNIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSF 183 Query: 190 VRV----ASRYFKGPELLVDYQMY--DYSLDMWSLGCMLASMIF-RKEPFFHGHDNYDQL 242 R + + PE+L + Y++D++S GC+ +I PF L Sbjct: 184 SRRSGVPGTEGWIAPEMLSEDCKDNPTYTVDIFSAGCVFYYVISEGYHPF------GKSL 237 Query: 243 VRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLD 302 R A +L D F +++ ++ A + ++ Sbjct: 238 QRQANILLGACNLDC--------------------------FHSDKHEDVI---ARELIE 268 Query: 303 KLLRYDHQSRLTAREAMEHPYFYTVVKD 330 K++ D Q R +A+ ++HP+F+++ K Sbjct: 269 KMIAMDPQQRPSAKHVLKHPFFWSLEKQ 296 >2A1A-B nrPDB Length = 284 Score = 184 bits (468), Expect = 5e-47, Method: Composition-based stats. Identities = 57/291 (19%), Positives = 117/291 (40%), Gaps = 33/291 (11%) Query: 27 ESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILE 86 +H V+ D++ + +G G + +VF+A + + + V+K +K +K +RE+K L Sbjct: 1 GAHTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVK-YNNEKAEREVKALA 59 Query: 87 NLRGGPNIITLADIVKD--------------PVSRTPALVFEHVNNTDFKQLY-----QT 127 L NI+ ++ + E + +Q + Sbjct: 60 KL-DHVNIVHYNGCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEK 118 Query: 128 LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE 187 L +I K +DY HS +++RD+KP N+ + + +++++ D+GL + Sbjct: 119 LDKVLALELFEQITKGVDYIHSKKLINRDLKPSNIFL-VDTKQVKIGDFGLVTSLKNDGK 177 Query: 188 YNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMI------FRKEPFFHGHDNYDQ 241 + + PE + Q Y +D+++LG +LA ++ F FF D D Sbjct: 178 RTRSKGTLRYMSPEQI-SSQDYGKEVDLYALGLILAELLHVCDTAFETSKFF--TDLRDG 234 Query: 242 LVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHL 292 ++ + L + E P ++IL + W++ +H Sbjct: 235 IISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTV--WKKSPEKNERHT 283 >4HVI-A nrPDB Length = 314 Score = 184 bits (468), Expect = 5e-47, Method: Composition-based stats. Identities = 47/205 (22%), Positives = 92/205 (44%), Gaps = 18/205 (8%) Query: 38 DYQLVRKLGRGKYSEVFEAI----NITNNEKVVVKILK---PVKKKKIKREIKILENLRG 90 + + +LG+G + V V VK L+ P +++ +REI+IL+ L Sbjct: 11 HLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKAL-H 69 Query: 91 GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----LTDYDIRFYMYEILKALDY 146 I+ + P ++ LV E++ + + Q L + Y +I K ++Y Sbjct: 70 SDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEY 129 Query: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRV----ASRYFKGPEL 202 S +HRD+ N++++ E +++ D+GLA+ ++Y V + ++ PE Sbjct: 130 LGSRRCVHRDLAARNILVESEAH-VKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPES 188 Query: 203 LVDYQMYDYSLDMWSLGCMLASMIF 227 L D ++ D+WS G +L + Sbjct: 189 LSD-NIFSRQSDVWSFGVVLYELFT 212 >1AD5-A nrPDB Length = 438 Score = 184 bits (467), Expect = 6e-47, Method: Composition-based stats. Identities = 42/283 (14%), Positives = 112/283 (39%), Gaps = 33/283 (11%) Query: 17 THRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEA-INITNNEKVVVKILKP--V 73 + +P++ W+ ++ + ++ +L +KLG G++ EV+ A N KV VK +KP + Sbjct: 165 SSKPQKPWEKDAWEIP---RESLKLEKKLGAGQFGEVWMATYNKHT--KVAVKTMKPGSM 219 Query: 74 KKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ-----TL 128 + E +++ L+ ++ L +V ++ E + + Sbjct: 220 SVEAFLAEANVMKTLQHDK-LVKLHAVV---TKEPIYIITEFMAKGSLLDFLKSDEGSKQ 275 Query: 129 TDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEY 188 + + +I + + + +HRD++ N+++ ++ D+GLA Sbjct: 276 PLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSA-SLVCKIADFGLAR-------- 326 Query: 189 NVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRI 245 V +++ + PE + ++ + D+WS G +L ++ + G N + + + Sbjct: 327 ---VGAKFPIKWTAPEAI-NFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRAL 382 Query: 246 AKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSE 288 + + ++ + + + + + V + Sbjct: 383 ERGYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDD 425 >5X5O-A nrPDB Length = 310 Score = 184 bits (466), Expect = 8e-47, Method: Composition-based stats. Identities = 51/204 (25%), Positives = 93/204 (45%), Gaps = 19/204 (9%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIIT 96 DD Q G G + V+ A I+ +++V VK L KI++E +IL L NII Sbjct: 15 DDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKL-----LKIEKEAEILSVLSH-RNIIQ 68 Query: 97 LADIVKDPVSRTPALVFEHVNNTDFKQLYQT-----LTDYDIRFYMYEILKALDYCHSM- 150 ++ +P + +V E+ + + + I + ++ K + Y H Sbjct: 69 FYGVILEPPNYG--IVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEA 126 Query: 151 --GIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQM 208 ++HRD+K NV+I + L++ D+G A +H + V + + PE++ + Sbjct: 127 PVKVIHRDLKSRNVVIAADG-VLKICDFG-ASRFHNHTTHMSLVGTFPWMAPEVIQSLPV 184 Query: 209 YDYSLDMWSLGCMLASMIFRKEPF 232 + D +S G +L M+ R+ PF Sbjct: 185 -SETCDTYSYGVVLWEMLTREVPF 207 >2PMN-X nrPDB Length = 348 Score = 184 bits (466), Expect = 9e-47, Method: Composition-based stats. Identities = 71/341 (20%), Positives = 141/341 (41%), Gaps = 68/341 (19%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPV--------------------KKK 76 +DY+++R L +GK++++ +N+ +K + K Sbjct: 31 NDYRIIRTLNQGKFNKIILCE--KDNKFYALKKYEKSLLEKKRDFTKSNNDKISIKSKYD 88 Query: 77 KIKREIKILENLRG-----GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTL--- 128 K E++I+ +++ IIT D +++E++ N + + Sbjct: 89 DFKNELQIITDIKNEYCLTCEGIITNYD--------EVYIIYEYMENDSILKFDEYFFVL 140 Query: 129 --------TDYDIRFYMYEILKALDYCH-SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA 179 I+ + +L + Y H I HRDVKP N+++D ++ +++L D+G + Sbjct: 141 DKNYTCFIPIQVIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMD-KNGRVKLSDFGES 199 Query: 180 EFYHPGQEYNVRVASRYFKGPELLVDYQMY-DYSLDMWSLGCMLASMIFRKEPFFHGHDN 238 E+ ++ + F PE + Y +D+WSLG L M + PF Sbjct: 200 EYMVD-KKIKGSRGTYEFMPPEFFSNESSYNGAKVDIWSLGICLYVMFYNVVPFS----- 253 Query: 239 YDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEAL 298 ++I+ V +L++ I NIE N L + K+ + + + +S E + Sbjct: 254 ----LKISLV----ELFNNIRTKNIEYPLDRNHFLYPLTNKK-----STCSNNFLSNEDI 300 Query: 299 DFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSM 339 DFL LR + R+T+ +A++H + + R S + Sbjct: 301 DFLKLFLRKNPAERITSEDALKHEWLADTNIEDLREFSKEL 341 >4PDO-A nrPDB Length = 299 Score = 183 bits (465), Expect = 1e-46, Method: Composition-based stats. Identities = 51/290 (17%), Positives = 114/290 (39%), Gaps = 34/290 (11%) Query: 18 HRPREYWDYESHVVEWGNQDD---YQLVRKLGRGKYSEVFEAINITNNEK----VVVKIL 70 P Y D V+++ + + +G G++ EV++ + T++ K V +K L Sbjct: 12 QDPHTYEDPNQAVLKFTTEIHPSCVTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTL 71 Query: 71 KPVKKKK----IKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ 126 K +K E I+ NII L ++ + ++ E++ N + + Sbjct: 72 KAGYTEKQRVDFLGEAGIMGQFSHH-NIIRLEGVISKY--KPMMIITEYMENGALDKFLR 128 Query: 127 T----LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFY 182 + + + I + Y +M +HRD+ N++++ + ++ D+GL+ Sbjct: 129 EKDGEFSVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNS-NLVCKVSDFGLSRVL 187 Query: 183 HPGQE--YNVRVA--SRYFKGPELLVDYQMYDYSLDMWSLGCMLAS-MIFRKEPFFH--G 235 E Y + PE + Y+ + + D+WS G ++ M + + P++ Sbjct: 188 EDDPEATYTTSGGKIPIRWTAPEAI-SYRKFTSASDVWSFGIVMWEVMTYGERPYWELSN 246 Query: 236 HDNYDQLVRIAKVLGTEDLYDYIDKYNIEL-------DPRFNDILGRHSR 278 H+ + ++ D I + ++ P+F DI+ + Sbjct: 247 HEVMKAINDGFRLPTPMDCPSAIYQLMMQCWQQERARRPKFADIVSILDK 296 >5KMM-A nrPDB Length = 329 Score = 183 bits (464), Expect = 1e-46, Method: Composition-based stats. Identities = 55/332 (16%), Positives = 118/332 (35%), Gaps = 75/332 (22%) Query: 17 THRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINIT-----NNEKVVVKILK 71 P+ + D H ++ + D L +LG G + +VF A + V VK LK Sbjct: 18 IENPQYFSDACVHHIK---RRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALK 74 Query: 72 PVK---KKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT- 127 ++ +RE ++L L+ +I+ + + R +VFE++ + D + ++ Sbjct: 75 EASESARQDFQREAELLTMLQHQ-HIVRFFGVCTE--GRPLLMVFEYMRHGDLNRFLRSH 131 Query: 128 -----------------LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRK 170 L + ++ + Y + +HRD+ N ++ + Sbjct: 132 GPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVG-QGLV 190 Query: 171 LRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIF 227 +++ D+G++ + Y V + + PE ++ Y+ + D+WS G +L + Sbjct: 191 VKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESIL-YRKFTTESDVWSFGVVLWEIFT 249 Query: 228 -RKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVH 286 K+P++ L + D I + PR Sbjct: 250 YGKQPWYQ--------------LSNTEAIDCITQGRELERPR------------------ 277 Query: 287 SENQHLVSPEALDFLDKLLRYDHQSRLTAREA 318 PE + + + Q R + ++ Sbjct: 278 -----ACPPEVYAIMRGCWQREPQQRHSIKDV 304 >4EUT-A nrPDB Length = 396 Score = 183 bits (464), Expect = 1e-46, Method: Composition-based stats. Identities = 63/349 (18%), Positives = 133/349 (38%), Gaps = 61/349 (17%) Query: 41 LVRKLGRGKYSEVFEAINITNNEKVVVKI------LKPVKKKKIKREIKILENLRGGPNI 94 L LG+G + VF + + +K+ L+PV + RE ++L+ L NI Sbjct: 13 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKL-NHKNI 69 Query: 95 ITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT------LTDYDIRFYMYEILKALDYCH 148 + L I ++ +R L+ E + + L + + + +++ +++ Sbjct: 70 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 129 Query: 149 SMGIMHRDVKPHNVM--IDHEHRKL-RLIDWGLAEFYHPGQEYNVRVASRYFKGPELLV- 204 GI+HR++KP N+M I + + + +L D+G A +++ + + P++ Sbjct: 130 ENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYER 189 Query: 205 ------DYQMYDYSLDMWSLGCMLASMIFRKEPFFH---GHDNYDQLVRIA------KVL 249 + Y ++D+WS+G PF N + + +I + Sbjct: 190 AVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAIS 249 Query: 250 GTEDLYDYIDKYNIELD--------------PRFNDILGRHSRKRWERFVHSENQHLVSP 295 G + + ++ ++ P +IL K W Sbjct: 250 GVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWG-------FDQFFA 302 Query: 296 EALDFLDKL-LRYDHQSRLTAREAMEHPY-----FYTVVKDQARMGSSS 338 E D L ++ + ++TA + H Y F+ +V Q ++ SS+ Sbjct: 303 ETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSN 351 >2RIO-A nrPDB Length = 434 Score = 182 bits (463), Expect = 2e-46, Method: Composition-based stats. Identities = 67/357 (18%), Positives = 123/357 (34%), Gaps = 73/357 (20%) Query: 43 RKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVK 102 + LG G V V VK + EIK+L PN+I Sbjct: 21 KILGYGSSGTVVF-QGSFQGRPVAVKRMLIDFCDIALMEIKLLTESDDHPNVIRYY--CS 77 Query: 103 DPVSRTPALVFEHVNNT--DF-------KQLYQTLTDYDIRFYMYEILKALDYCHSMGIM 153 + R + E N D + + +Y+ + +I + + HS+ I+ Sbjct: 78 ETTDRFLYIALELCNLNLQDLVESKNVSDENLKLQKEYNPISLLRQIASGVAHLHSLKII 137 Query: 154 HRDVKPHNVMIDH------------EHRKLRLIDWGLAEFYHPGQ-----EYNVRVASRY 196 HRD+KP N+++ E+ ++ + D+GL + GQ N + Sbjct: 138 HRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFRTNLNNPSGTSG 197 Query: 197 FKGPELLVDY------QMYDYSLDMWSLGCMLASMIF-RKEPFFHGHDNYDQLVRIAKVL 249 ++ PELL + + S+D++S+GC+ ++ K PF D Y + I + + Sbjct: 198 WRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPF---GDKYSRESNIIRGI 254 Query: 250 GTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDH 309 + D + + + EA D + +++ +D Sbjct: 255 FSLDEMKCL------------------------------HDRSLIAEATDLISQMIDHDP 284 Query: 310 QSRLTAREAMEHPYFYTVVKDQARM----GSSSMPGGSTPVSSANMMSGISSVPTPS 362 R TA + + HP F+ K + + P + S PS Sbjct: 285 LKRPTAMKVLRHPLFWPKSKKLEFLLKVSDRLEIENRDPPSALLMKFDAGSDFVIPS 341 >5B2L-A nrPDB Length = 324 Score = 182 bits (462), Expect = 2e-46, Method: Composition-based stats. Identities = 55/315 (17%), Positives = 117/315 (37%), Gaps = 51/315 (16%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK----PVKKKKIKREIKILENLRGGP 92 +D + + ++G G +V++ + VK ++ + K+I ++ ++ P Sbjct: 17 NDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCP 76 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTL----TDYDIRFYMYEILKALDYC- 147 I+ + + E + T ++L + + + + I+KAL Y Sbjct: 77 YIVQCFGTF--ITNTDVFIAMELM-GTSAEKLKKRMQGPIPERILGKMTVAIVKALYYLK 133 Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLV--- 204 G++HRDVKP N+++D E +++L D+G++ + + PE + Sbjct: 134 EKHGVIHRDVKPSNILLD-ERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPD 192 Query: 205 -DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNI 263 YD D+WSLG L + + P+ + +++ L ++ + Sbjct: 193 PTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQ---------------- 236 Query: 264 ELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323 E P +G S + F+ L DH+ R + +EH + Sbjct: 237 EEPPLLPGHMG------------------FSGDFQSFVKDCLTKDHRKRPKYNKLLEHSF 278 Query: 324 FYTVVKDQARMGSSS 338 + + S Sbjct: 279 IKRYETLEVDVASWF 293 >4EUU-A nrPDB Length = 319 Score = 182 bits (461), Expect = 3e-46, Method: Composition-based stats. Identities = 46/249 (18%), Positives = 98/249 (39%), Gaps = 25/249 (10%) Query: 41 LVRKLGRGKYSEVFEAINITNNEKVVVKI------LKPVKKKKIKREIKILENLRGGPNI 94 L LG+G + VF + + +K+ L+PV + RE ++L+ L NI Sbjct: 13 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKL-NHKNI 69 Query: 95 ITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT------LTDYDIRFYMYEILKALDYCH 148 + L I ++ +R L+ E + + L + + + +++ +++ Sbjct: 70 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 129 Query: 149 SMGIMHRDVKPHNVM--IDHEHRKL-RLIDWGLAEFYHPGQEYNVRVASRYFKGPELLV- 204 GI+HR++KP N+M I + + + +L D+G A +++ + + P++ Sbjct: 130 ENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYER 189 Query: 205 ------DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYI 258 + Y ++D+WS+G PF + K++ + Sbjct: 190 AVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAIS 249 Query: 259 DKYNIELDP 267 E P Sbjct: 250 GVQKAENGP 258 >3QGY-A nrPDB Length = 286 Score = 182 bits (461), Expect = 3e-46, Method: Composition-based stats. Identities = 43/260 (16%), Positives = 104/260 (40%), Gaps = 26/260 (10%) Query: 35 NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK--PVKKKKIKREIKILENLRGGP 92 + + V+++G G++ V + N +KV +K +K + + E +++ L P Sbjct: 25 DPSELTFVQEIGSGQFGLVHLGYWL-NKDKVAIKTIKEGSMSEDDFIEEAEVMMKLSH-P 82 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----LTDYDIRFYMYEILKALDYCH 148 ++ L + + LVFE + + +T + ++ + + Y Sbjct: 83 KLVQLYGVCLEQA--PICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLE 140 Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLVD 205 ++HRD+ N ++ E++ +++ D+G+ F Q Y +++ + PE+ Sbjct: 141 EACVIHRDLAARNCLVG-ENQVIKVSDFGMTRFVLDDQ-YTSSTGTKFPVKWASPEVF-S 197 Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIA----------KVLGTEDLY 255 + Y D+WS G ++ + + + N + + I+ + Sbjct: 198 FSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIM 257 Query: 256 DYIDKYNIELDPRFNDILGR 275 ++ K E P F+ +L + Sbjct: 258 NHCWKERPEDRPAFSRLLRQ 277 >2PSQ-A nrPDB Length = 370 Score = 182 bits (461), Expect = 3e-46, Method: Composition-based stats. Identities = 47/275 (17%), Positives = 110/275 (40%), Gaps = 37/275 (13%) Query: 36 QDDYQLVRKLGRGKYSEVFEA----INITNNEK---VVVKILKPVKKKK----IKREIKI 84 +D L + LG G + +V A I+ ++ V VK+LK +K + E+++ Sbjct: 80 RDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEM 139 Query: 85 LENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----------------- 127 ++ + NII L ++ E+ + + ++ + Sbjct: 140 MKMIGKHKNIINLLGACTQ--DGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPE 197 Query: 128 --LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPG 185 +T D+ Y++ + ++Y S +HRD+ NV++ E+ +++ D+GLA + Sbjct: 198 EQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVT-ENNVMKIADFGLARDINNI 256 Query: 186 QEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQL 242 Y R + PE L D ++Y + D+WS G ++ + + G + Sbjct: 257 DYYKKTTNGRLPVKWMAPEALFD-RVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELF 315 Query: 243 VRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHS 277 + + + + ++ + + ++ + + Sbjct: 316 KLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRP 350 >6O8B-A nrPDB Length = 665 Score = 181 bits (460), Expect = 4e-46, Method: Composition-based stats. Identities = 66/390 (16%), Positives = 143/390 (36%), Gaps = 65/390 (16%) Query: 41 LVRKLGRGKYSEVFEAINITNNEKVVVKI------LKPVKKKKIKREIKILENLRGGPNI 94 L LG+G + VF + + +K+ L+PV + RE ++L+ L NI Sbjct: 19 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKL-NHKNI 75 Query: 95 ITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT------LTDYDIRFYMYEILKALDYCH 148 + L I ++ +R L+ E + + L + + + +++ +++ Sbjct: 76 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 135 Query: 149 SMGIMHRDVKPHNVM--IDHEHRKL-RLIDWGLAEFYHPGQEYNVRVASRYFKGPELLV- 204 GI+HR++KP N+M I + + + +L D+G A +++ + + P++ Sbjct: 136 ENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVELYGTEEYLHPDMYER 195 Query: 205 ------DYQMYDYSLDMWSLGCMLASMIFRKEPFFH---GHDNYDQLVRIA------KVL 249 + Y ++D+WS+G PF N + + +I + Sbjct: 196 AVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAIS 255 Query: 250 GTEDLYDYIDKYNIELD--------------PRFNDILGRHSRKRWERFVHSENQHLVSP 295 G + + ++ ++ P +IL K W Sbjct: 256 GVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWG-------FDQFFA 308 Query: 296 EALDFLDKL-LRYDHQSRLTAREAMEHPY-----FYTVVKDQARMGSSSM----PGGSTP 345 E D L ++ + ++TA + H Y F+ +V Q ++ SS+ G Sbjct: 309 ETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLV 368 Query: 346 VSSANMMSGISSVPTPSPLGPLAGSPVIAA 375 + + +P+ ++ P+ Sbjct: 369 LEPGRLAQHFPKTTEENPIFVVSREPLDTI 398 >6NT9-A nrPDB Length = 742 Score = 181 bits (460), Expect = 4e-46, Method: Composition-based stats. Identities = 66/390 (16%), Positives = 143/390 (36%), Gaps = 65/390 (16%) Query: 41 LVRKLGRGKYSEVFEAINITNNEKVVVKI------LKPVKKKKIKREIKILENLRGGPNI 94 L LG+G + VF + + +K+ L+PV + RE ++L+ L NI Sbjct: 11 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKL-NHKNI 67 Query: 95 ITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT------LTDYDIRFYMYEILKALDYCH 148 + L I ++ +R L+ E + + L + + + +++ +++ Sbjct: 68 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 127 Query: 149 SMGIMHRDVKPHNVM--IDHEHRKL-RLIDWGLAEFYHPGQEYNVRVASRYFKGPELLV- 204 GI+HR++KP N+M I + + + +L D+G A +++ + + P++ Sbjct: 128 ENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYER 187 Query: 205 ------DYQMYDYSLDMWSLGCMLASMIFRKEPFFH---GHDNYDQLVRIA------KVL 249 + Y ++D+WS+G PF N + + +I + Sbjct: 188 AVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAIS 247 Query: 250 GTEDLYDYIDKYNIELD--------------PRFNDILGRHSRKRWERFVHSENQHLVSP 295 G + + ++ ++ P +IL K W Sbjct: 248 GVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWG-------FDQFFA 300 Query: 296 EALDFLDKL-LRYDHQSRLTAREAMEHPY-----FYTVVKDQARMGSSSM----PGGSTP 345 E D L ++ + ++TA + H Y F+ +V Q ++ SS+ G Sbjct: 301 ETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLV 360 Query: 346 VSSANMMSGISSVPTPSPLGPLAGSPVIAA 375 + + +P+ ++ P+ Sbjct: 361 LEPGRLAQHFPKTTEENPIFVVSREPLNTI 390 >5VO2-A nrPDB Length = 300 Score = 181 bits (459), Expect = 6e-46, Method: Composition-based stats. Identities = 46/239 (19%), Positives = 95/239 (39%), Gaps = 14/239 (5%) Query: 45 LGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDP 104 +G G VF + E+V VK ++ +K+ IK L L+ PNIIT + Sbjct: 20 VGSGAQGAVFLGR--FHGEEVAVKKVRDLKETDIKH----LRKLKH-PNIITFKGVCTQ- 71 Query: 105 VSRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHN 161 + ++ E ++ + +T + + I ++Y H I+HRD+K N Sbjct: 72 -APCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPN 130 Query: 162 VMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCM 221 ++I ++ +++ D+G ++ + + PE++ + + +D+WS G + Sbjct: 131 MLITYDD-VVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRN-EPVSEKVDIWSFGVV 188 Query: 222 LASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKR 280 L ++ + P+ + + L D + I L +N R Sbjct: 189 LWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFR 247 >6FEX-A nrPDB Length = 321 Score = 180 bits (458), Expect = 7e-46, Method: Composition-based stats. Identities = 56/289 (19%), Positives = 108/289 (37%), Gaps = 52/289 (17%) Query: 36 QDDYQLVRKLGRGKYSEVFEA----------------INITNNEKVVVKILKPVKKK--- 76 + + KLG G++ EV + + V VKIL+P K Sbjct: 15 RSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNAR 74 Query: 77 -KIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ--------- 126 +E+KI+ L+ PNII L + ++ +++ N D Q Sbjct: 75 NDFLKEVKIMSRLKD-PNIIRLLGVC--VQDDPLCMITDYMENGDLNQFLSAHQLEDKAA 131 Query: 127 -------TLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA 179 T++ + +I + Y ++ +HRD+ N ++ E+ +++ D+G++ Sbjct: 132 EGAPGDPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVG-ENFTIKIADFGMS 190 Query: 180 EFYHPGQEYNVR---VASRYFKGPELLVDYQMYDYSLDMWSLGCMLAS--MIFRKEPFFH 234 + G Y V+ V + E ++ + + D+W+ G L M+ R +PF Sbjct: 191 RNLYAGDYYRVQGRAVLPIRWMAWECIL-MGKFTTASDVWAFGVTLWEVLMLCRAQPFGQ 249 Query: 235 GHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWER 283 D ++ + G E D + + P L + W R Sbjct: 250 LTDE-----QVIENAG-EFFRDQGRQVYLSRPPACPQGLYELMLRCWSR 292 >4K33-A nrPDB Length = 325 Score = 180 bits (456), Expect = 1e-45, Method: Composition-based stats. Identities = 56/287 (19%), Positives = 108/287 (37%), Gaps = 47/287 (16%) Query: 35 NQDDYQLVRKLGRGKYSEVFEA----INITNNEK---VVVKILKPVKKKK----IKREIK 83 ++ L + LG G + +V A I+ K V VK+LK K + E++ Sbjct: 34 SRARLTLGKPLGEGAFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEME 93 Query: 84 ILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---------------- 127 +++ + NII L ++ E+ + ++ + Sbjct: 94 MMKMIGKHKNIINLLGACTQ--GGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTSKPP 151 Query: 128 ---LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHP 184 LT D+ Y++ + ++Y S +HRD+ NV++ ++ +++ D+GLA H Sbjct: 152 EEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDN-VMKIADFGLARDVHN 210 Query: 185 GQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQ 241 Y R + PE L D ++Y + D+WS G +L + + G + Sbjct: 211 LDYYKETTNGRLPVKWMAPEALFD-RVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEEL 269 Query: 242 LVRIAK-------VLGTEDLYDYIDKY---NIELDPRFNDILGRHSR 278 + + T DLY + + P F ++ R Sbjct: 270 FKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDR 316 >5EG3-A nrPDB Length = 334 Score = 179 bits (454), Expect = 2e-45, Method: Composition-based stats. Identities = 50/303 (16%), Positives = 117/303 (38%), Gaps = 38/303 (12%) Query: 36 QDDYQLVRKLGRGKYSEVFEA----INITNNEK---VVVKILKPVKKKK----IKREIKI 84 +D L + LG G + +V A I+ ++ V VK+LK +K + E+++ Sbjct: 34 RDKLTLGKPLGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEM 93 Query: 85 LENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----------------- 127 ++ + NII L ++ + + + ++ + Sbjct: 94 MKMIGKHKNIINLLGACTQ--DGPLYVIVAYASKGNLREYLRARRPPGMELSPDINRVPE 151 Query: 128 --LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPG 185 +T D+ Y++ + ++Y S +HRD+ NV++ E+ +++ D+GLA + Sbjct: 152 EQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVT-ENNVMKIADFGLARDINNI 210 Query: 186 QEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQL 242 + R + PE L D ++Y + D+WS G ++ + + G + Sbjct: 211 DFFKETTNGRLPVKWMAPEALFD-RVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELF 269 Query: 243 VRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSR-KRWERFVHSENQHLVSPEALDFL 301 + + + + ++ + + ++ + + K+ + + E LD Sbjct: 270 KLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLS 329 Query: 302 DKL 304 L Sbjct: 330 QPL 332 >3KUL-B nrPDB Length = 325 Score = 179 bits (453), Expect = 2e-45, Method: Composition-based stats. Identities = 54/299 (18%), Positives = 114/299 (38%), Gaps = 27/299 (9%) Query: 19 RPREYWDYESHVVEWGNQ---DDYQLVRKLGRGKYSEVFEAINITNNEK---VVVKILKP 72 P Y + + + + + +G G EV ++ V +K LK Sbjct: 28 EPHTYEEPGRAGRSFTREIEASRIHIEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKA 87 Query: 73 VKKKKIKR----EIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT- 127 ++ +R E I+ PNII L +V R +V E++ N +T Sbjct: 88 GYTERQRRDFLSEASIMGQF-DHPNIIRLEGVVTR--GRLAMIVTEYMENGSLDTFLRTH 144 Query: 128 ---LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHP 184 T + + + + Y +G +HRD+ NV++D + ++ D+GL+ Sbjct: 145 DGQFTIMQLVGMLRGVGAGMRYLSDLGYVHRDLAARNVLVDS-NLVCKVSDFGLSRVLED 203 Query: 185 GQE--YNVRVA--SRYFKGPELLVDYQMYDYSLDMWSLGCMLAS-MIFRKEPFFHGHDNY 239 + Y + PE + ++ + + D+WS G ++ + + + P+++ N Sbjct: 204 DPDAAYTTTGGKIPIRWTAPEAIA-FRTFSSASDVWSFGVVMWEVLAYGERPYWN-MTNR 261 Query: 240 DQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEAL 298 D + + + + + ++ R R R+ + V + + SPE+L Sbjct: 262 DVISSVEEGYRLPAPMGCPHALHQLMLDCWHK--DRAQRPRFSQIVSVLDALIRSPESL 318 >4XCU-A nrPDB Length = 300 Score = 179 bits (453), Expect = 3e-45, Method: Composition-based stats. Identities = 56/289 (19%), Positives = 108/289 (37%), Gaps = 42/289 (14%) Query: 36 QDDYQLVRKLGRGKYSEVFEAI-------NITNNEKVVVKILKPVKKKK----IKREIKI 84 +D L + LG G + +V A V VK+LK K + E+++ Sbjct: 16 RDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEV 75 Query: 85 LENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----------LTDYDIR 134 ++ + NII L + ++ E + ++ + L+ + Sbjct: 76 MKLIGRHKNIINLLGVCTQEG--PLYVIVECAAKGNLREFLRARRPPGSSEGPLSFPVLV 133 Query: 135 FYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVAS 194 Y++ + + Y S +HRD+ NV++ ++ +++ D+GLA H Y Sbjct: 134 SCAYQVARGMQYLESRKCIHRDLAARNVLVTEDN-VMKIADFGLARGVHHIDYYKKTSNG 192 Query: 195 RY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGT 251 R + PE L D ++Y + D+WS G +L + + G + Sbjct: 193 RLPVKWMAPEALFD-RVYTHQSDVWSFGILLWEIFTLGGSPYPG-------------IPV 238 Query: 252 EDLYDYIDK-YNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALD 299 E+L+ + + + ++ P L R+ W EALD Sbjct: 239 EELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALD 287 >6BSD-A nrPDB Length = 876 Score = 178 bits (452), Expect = 3e-45, Method: Composition-based stats. Identities = 56/295 (18%), Positives = 108/295 (36%), Gaps = 58/295 (19%) Query: 36 QDDYQLVRKLGRGKYSEVFEA----------------INITNNEKVVVKILKPVKKK--- 76 + + KLG G++ EV + + V VKIL+P K Sbjct: 570 RSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNAR 629 Query: 77 -KIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ--------- 126 +E+KI+ L+ PNII L + ++ +++ N D Q Sbjct: 630 NDFLKEVKIMSRLKD-PNIIRLLGVC--VQDDPLCMITDYMENGDLNQFLSAHQLEDKAA 686 Query: 127 -------------TLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRL 173 T++ + +I + Y ++ +HRD+ N ++ E+ +++ Sbjct: 687 EGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVG-ENFTIKI 745 Query: 174 IDWGLAEFYHPGQEYNVR---VASRYFKGPELLVDYQMYDYSLDMWSLGCMLAS--MIFR 228 D+G++ + G Y V+ V + E ++ + + D+W+ G L M+ R Sbjct: 746 ADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECIL-MGKFTTASDVWAFGVTLWEVLMLCR 804 Query: 229 KEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWER 283 +PF D ++ + G E D + + P L + W R Sbjct: 805 AQPFGQLTDE-----QVIENAG-EFFRDQGRQVYLSRPPACPQGLYELMLRCWSR 853 >4M7I-A nrPDB Length = 299 Score = 178 bits (451), Expect = 5e-45, Method: Composition-based stats. Identities = 49/248 (19%), Positives = 105/248 (42%), Gaps = 39/248 (15%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK----PVKKKKIKREIKILENLRGGPN 93 D++ ++ LGRG + VFEA N ++ +K ++ + ++K+ RE+K L L P Sbjct: 6 DFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEH-PG 64 Query: 94 IITLADIVKDPVSR----------TPALVFEHVNNTDFKQLYQ---TLTDYD---IRFYM 137 I+ + + + + + + K T+ + + Sbjct: 65 IVRYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIF 124 Query: 138 YEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE---------- 187 +I +A+++ HS G+MHRD+KP N+ + +++ D+GL +E Sbjct: 125 LQIAEAVEFLHSKGLMHRDLKPSNIFFTMDD-VVKVGDFGLVTAMDQDEEEQTVLTPMPA 183 Query: 188 ---YNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVR 244 + +V ++ + PE + Y + +D++SLG +L +++ PF + L Sbjct: 184 YARHTGQVGTKLYMSPEQIHGNS-YSHKVDIFSLGLILFELLY---PFSTQMERVRTLTD 239 Query: 245 IAKVLGTE 252 + + Sbjct: 240 VRNLKFPP 247 >4XLV-A nrPDB Length = 328 Score = 178 bits (451), Expect = 5e-45, Method: Composition-based stats. Identities = 63/352 (17%), Positives = 123/352 (34%), Gaps = 75/352 (21%) Query: 7 SRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFE--AINITNNE- 63 S Y + P + + V +++ L+R+LG+G + V+E A +I E Sbjct: 12 SSNPEYLSASDVFPSSVYVPDEWEV---SREKITLLRELGQGSFGMVYEGNARDIIKGEA 68 Query: 64 --KVVVKILKPV----KKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVN 117 +V VK + ++ + E +++ +++ L +V + +V E + Sbjct: 69 ETRVAVKTVNESASLRERIEFLNEASVMKGFTCH-HVVRLLGVV--SKGQPTLVVMELMA 125 Query: 118 NTDFKQLYQTLTDY-------------DIRFYMYEILKALDYCHSMGIMHRDVKPHNVMI 164 + D K ++L ++ EI + Y ++ +HRD+ N M+ Sbjct: 126 HGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMV 185 Query: 165 DHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCM 221 H+ +++ D+G+ + Y + PE L D ++ S DMWS G + Sbjct: 186 AHD-FTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKD-GVFTTSSDMWSFGVV 243 Query: 222 LASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRW 281 L + E + G N +Q+++ G D D Sbjct: 244 LWEITSLAEQPYQGLSN-EQVLKFVMDGGYLDQPDNC----------------------- 279 Query: 282 ERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAME------HPYFYTV 327 D + +++ R T E + HP F V Sbjct: 280 ------------PERVTDLMRMCWQFNPNMRPTFLEIVNLLKDDLHPSFPEV 319 >4IDT-A nrPDB Length = 356 Score = 177 bits (450), Expect = 5e-45, Method: Composition-based stats. Identities = 55/233 (23%), Positives = 92/233 (39%), Gaps = 25/233 (10%) Query: 15 VNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK 74 +P +Y E V W +R LGRG + EV + + VK ++ Sbjct: 59 TEKLKPVDYEYRE--EVHWATHQ----LR-LGRGSFGEVHRMEDKQTGFQCAVKKVRLEV 111 Query: 75 KKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ---TLTDY 131 + E+ L P I+ L V++ + E + QL + L + Sbjct: 112 FRA--EELMACAGLT-SPRIVPLYGAVRE--GPWVNIFMELLEGGSLGQLVKEQGCLPED 166 Query: 132 DIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVR 191 +Y+ + L+ L+Y HS I+H DVK NV++ + L D+G A P Sbjct: 167 RALYYLGQALEGLEYLHSRRILHGDVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKDL 226 Query: 192 V------ASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEP---FFHG 235 + + PE+++ + D +D+WS CM+ M+ P FF G Sbjct: 227 LTGDYIPGTETHMAPEVVLG-RSCDAKVDVWSSCCMMLHMLNGCHPWTQFFRG 278 >6E4F-A nrPDB Length = 290 Score = 177 bits (450), Expect = 5e-45, Method: Composition-based stats. Identities = 47/262 (17%), Positives = 111/262 (42%), Gaps = 28/262 (10%) Query: 35 NQDDYQLVRKLGRGKYSEVFEAINITNNEK-VVVKILK--PVKKKKIKREIKILENLRGG 91 + D +++LG G++ V + V +K++K + + + E K++ NL Sbjct: 29 DPKDLTFLKELGTGQFGVVKYGKWR--GQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHE 86 Query: 92 PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDY----DIRFYMYEILKALDYC 147 ++ L + R ++ E++ N + + + ++ +A++Y Sbjct: 87 K-LVQLYGVCTKQ--RPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYL 143 Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLV 204 S +HRD+ N +++ + +++ D+GL+ + EY V S++ + PE+L+ Sbjct: 144 ESKQFLHRDLAARNCLVN-DQGVVKVSDFGLSRYVLDD-EYTSSVGSKFPVRWSPPEVLM 201 Query: 205 DYQMYDYSLDMWSLGCMLASMIF-RKEPF--FHGHDNYDQLVRIAKV----LGTEDLYDY 257 Y + D+W+ G ++ + K P+ F + + + + ++ L +E +Y Sbjct: 202 -YSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTI 260 Query: 258 IDKYNIE---LDPRFNDILGRH 276 + E P F +L Sbjct: 261 MYSCWHEKADERPTFKILLSNI 282 >3UIU-A nrPDB Length = 306 Score = 177 bits (450), Expect = 6e-45, Method: Composition-based stats. Identities = 58/303 (19%), Positives = 118/303 (38%), Gaps = 46/303 (15%) Query: 29 HVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENL 88 + V+ D++ + +G G + +VF+A + + + V++ +K +K +RE+K L L Sbjct: 4 YTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIRRVK-YNNEKAEREVKALAKL 62 Query: 89 RGGPNIITLADIVK------------------DPVS---------RTPALVFEHVNNTDF 121 NI+ DP + + + E + Sbjct: 63 -DHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTL 121 Query: 122 KQLY-----QTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDW 176 +Q + L +I K +DY HS ++HRD+KP N+ + + +++++ D+ Sbjct: 122 EQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFL-VDTKQVKIGDF 180 Query: 177 GLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMI------FRKE 230 GL + + + PE + Q Y +D+++LG +LA ++ F Sbjct: 181 GLVTSLKNDGKRTRSKGTLRYMSPEQI-SSQDYGKEVDLYALGLILAELLHVCDTAFETS 239 Query: 231 PFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQ 290 FF D D ++ + L + E P ++IL + W++ + Sbjct: 240 KFF--TDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTV--WKKSPEKNER 295 Query: 291 HLV 293 H Sbjct: 296 HTC 298 >3SXS-A nrPDB Length = 268 Score = 177 bits (449), Expect = 7e-45, Method: Composition-based stats. Identities = 40/261 (15%), Positives = 110/261 (42%), Gaps = 25/261 (9%) Query: 35 NQDDYQLVRKLGRGKYSEVFEAINITNNEK-VVVKILK--PVKKKKIKREIKILENLRGG 91 +++ L+++LG G++ V + V VK++K + + + +E + + L Sbjct: 6 KREEITLLKELGSGQFGVVKLGKWK--GQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSH- 62 Query: 92 PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----LTDYDIRFYMYEILKALDYC 147 P ++ + +V E+++N ++ L + Y++ + + + Sbjct: 63 PKLVKFYGVC--SKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFL 120 Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLV 204 S +HRD+ N ++D + +++ D+G+ + Q Y V +++ + PE+ Sbjct: 121 ESHQFIHRDLAARNCLVDRD-LCVKVSDFGMTRYVLDDQ-YVSSVGTKFPVKWSAPEVFH 178 Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKV-------LGTEDLYDY 257 ++ Y D+W+ G ++ + + + + N + ++++++ L ++ +Y Sbjct: 179 YFK-YSSKSDVWAFGILMWEVFSLGKMPYDLYTNSEVVLKVSQGHRLYRPHLASDTIYQI 237 Query: 258 IDKYNIELDPRFNDILGRHSR 278 + EL + S Sbjct: 238 MYSCWHELPEKRPTFQQLLSS 258 >6CTH-A nrPDB Length = 309 Score = 177 bits (449), Expect = 7e-45, Method: Composition-based stats. Identities = 57/247 (23%), Positives = 106/247 (42%), Gaps = 21/247 (8%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIK---REIKILENLRGGPNI 94 ++ KLG G + V+ ++ + VK + K+ IK E+KI+ LR N+ Sbjct: 16 NFNAENKLGEGGFGSVYRGFLRDSDTYIAVKKVSRASKQGIKEYASEVKIISRLRH-KNL 74 Query: 95 ITLADIVKDPVSRTPALVFEHVNNTDFKQLY---QTLTDYDIRF-YMYEILKALDYCHSM 150 + L + LV+E + N ++L +++R+ + ++ AL Y H Sbjct: 75 VKLIGWCHERGE--LMLVYEFMANGSLDSHIFKGKSLLTWEVRYRIVKDLASALLYLHEE 132 Query: 151 G---IMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHP--GQEYNVRVASRYFKGPELLVD 205 G ++HRD+K N+M+D +L D+GLA G + + + + PE L Sbjct: 133 GDHCVLHRDIKTSNIMLDS-SFNAKLGDFGLARLVDHAKGLKKTLLAGTVGYMAPECLSS 191 Query: 206 YQMYDYSLDMWSLGCMLASMIFRK---EPFFHGHDNYDQLVRIAKVLGTEDLYDYID-KY 261 + D++S G + + + EP F + + + + G E + D D K Sbjct: 192 GKA-SKESDVYSFGVVALEIASGRRSIEPKFEESEALLLVPWVWESYGNERILDIADRKL 250 Query: 262 NIELDPR 268 + DP+ Sbjct: 251 GMAFDPK 257 >4Y83-A nrPDB Length = 332 Score = 177 bits (449), Expect = 8e-45, Method: Composition-based stats. Identities = 59/338 (17%), Positives = 123/338 (36%), Gaps = 51/338 (15%) Query: 3 GPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLG-----RGKYSEVFEAI 57 G P + + ++ + +S V+ + Y R +G RG + +V+ A Sbjct: 37 GQRPQESGILLNMVITPQNGRYQIDSDVLLIPWKLTY---RNIGSDFIPRGAFGKVYLAQ 93 Query: 58 NITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVN 117 +I +++ K++ + K EI+ NI L V T L E Sbjct: 94 DIKTKKRMACKLIPVDQFKPSDVEIQA---CFRHENIAELYGAV--LWGETVHLFMEAGE 148 Query: 118 NTDFKQLYQT---LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLI 174 + ++ + +++I + +LK LD+ HS ++H D+KP N++ L+ Sbjct: 149 GGSVLEKLESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHHDIKPSNIVFMSTKAV--LV 206 Query: 175 DWGLAEFYHPGQEY-NVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFF 233 D+GL+ + + + PE+++ + + D++SLG L M P Sbjct: 207 DFGLSVQMTEDVYFPKDLRGTEIYMSPEVIL-CRGHSTKADIYSLGATLIHMQTGTPP-- 263 Query: 234 HGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLV 293 ++ +Y P + I+ + + + Sbjct: 264 -----------------------WVKRYPRSAYPSYLYIIHKQAPP------LEDIADDC 294 Query: 294 SPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQ 331 SP + ++ L + R A + ++H +DQ Sbjct: 295 SPGMRELIEASLERNPNHRPRAADLLKHEALNPPREDQ 332 >4XI2-A nrPDB Length = 446 Score = 176 bits (447), Expect = 1e-44, Method: Composition-based stats. Identities = 46/262 (17%), Positives = 111/262 (42%), Gaps = 28/262 (10%) Query: 35 NQDDYQLVRKLGRGKYSEVFEAINITNNEK-VVVKILK--PVKKKKIKREIKILENLRGG 91 + D +++LG G++ V + V +K+++ + + + E K++ NL Sbjct: 185 DPKDLTFLKELGTGQFGVVKYGKWR--GQYDVAIKMIREGSMSEDEFIEEAKVMMNLSHE 242 Query: 92 PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDY----DIRFYMYEILKALDYC 147 ++ L + R ++ E++ N + + + ++ +A++Y Sbjct: 243 K-LVQLYGVCTKQ--RPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYL 299 Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLV 204 S +HRD+ N +++ + +++ D+GL+ + EY V S++ + PE+L+ Sbjct: 300 ESKQFLHRDLAARNCLVN-DQGVVKVSDFGLSRYVLDD-EYTSSVGSKFPVRWSPPEVLM 357 Query: 205 DYQMYDYSLDMWSLGCMLASMIF-RKEPF--FHGHDNYDQLVRIAKV----LGTEDLYDY 257 Y + D+W+ G ++ + K P+ F + + + + ++ L +E +Y Sbjct: 358 -YSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASERVYTI 416 Query: 258 IDKYNIE---LDPRFNDILGRH 276 + E P F +L Sbjct: 417 MYSCWHEKADERPSFKILLSNI 438 >2WTK-B nrPDB Length = 373 Score = 176 bits (446), Expect = 2e-44, Method: Composition-based stats. Identities = 69/358 (19%), Positives = 126/358 (35%), Gaps = 41/358 (11%) Query: 39 YQLVRKLGRGKYS---EVFEAINITNNEKVVVKILKPVKKKK-----IKREIKILENLRG 90 Y+L+ +G+G + V A E V V+ + ++ E+ + L Sbjct: 11 YELLTVIGKG-FEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHV-SKLFN 68 Query: 91 GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY-----QTLTDYDIRFYMYEILKALD 145 PNI+ +V + K L + + I + + +LKALD Sbjct: 69 HPNIVPYRATF--IADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALD 126 Query: 146 YCHSMGIMHRDVKPHNVMIDHEHR--------KLRLIDWGLA-EFYHPGQEYNVRVASRY 196 Y H MG +HR VK +++I + + L +I G H +Y+V+V Sbjct: 127 YIHHMGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSVKV--LP 184 Query: 197 FKGPELL-VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLY 255 + PE+L + Q YD D++S+G + PF L ++ + Sbjct: 185 WLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPCLLDT 244 Query: 256 DYIDKYNIELDPRFN--------DILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRY 307 I + + P + + R SP F+++ L+ Sbjct: 245 STIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTFSPHFHHFVEQCLQR 304 Query: 308 DHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLG 365 + +R +A + H +F + + S ++P PV+ G S G Sbjct: 305 NPDARPSASTLLNHSFFKQIKRR----ASEALPELLRPVTPITNFEGSQSQDHSGIFG 358 >4LRM-A nrPDB Length = 334 Score = 175 bits (445), Expect = 2e-44, Method: Composition-based stats. Identities = 58/311 (18%), Positives = 132/311 (42%), Gaps = 37/311 (11%) Query: 26 YESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKV----VVKILK----PVKKKK 77 ++ + +++ ++ LG G + V++ + I EKV +K L+ P K+ Sbjct: 8 PNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKE 67 Query: 78 IKREIKILENLRG--GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----LTDY 131 I E ++ ++ P++ L I ++ T L+ + + + + Sbjct: 68 ILDEAYVMASVDNPGNPHVCRLLGIC---LTSTVQLITQLMPFGCLLDYVREHKDNIGSQ 124 Query: 132 DIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFY-HPGQEYNV 190 + + +I K ++Y ++HRD+ NV++ + +++ D+GLA+ +EY+ Sbjct: 125 YLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTP-QHVKITDFGLAKLLGAEEKEYHA 183 Query: 191 RVASRY--FKGPELLVDYQMYDYSLDMWSLGCMLAS-MIFRKEPF--FHGHDNYDQLVRI 245 + E ++ +++Y + D+WS G + M F +P+ + L + Sbjct: 184 EGGKVPIKWMALESIL-HRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKG 242 Query: 246 AKV----LGTEDLYDYIDKYNI---ELDPRFNDILGRHSR-----KRWERFVHSENQHLV 293 ++ + T D+Y + K + + P+F +++ S+ +R+ E HL Sbjct: 243 ERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLP 302 Query: 294 SPEALDFLDKL 304 SP +F L Sbjct: 303 SPTDSNFYRAL 313 >1LUF-A nrPDB Length = 343 Score = 175 bits (445), Expect = 2e-44, Method: Composition-based stats. Identities = 46/261 (17%), Positives = 98/261 (37%), Gaps = 50/261 (19%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNN-------EKVVVKILKPV----KKKKIKREIKI 84 +++ + VR +G G + VF+A V VK+LK + +RE + Sbjct: 46 RNNIEYVRDIGEGAFGRVFQAR--APGLLPYEPFTMVAVKMLKEEASADMQADFQREAAL 103 Query: 85 LENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDI----------- 133 + PNI+ L + V + L+FE++ D + ++++ + + Sbjct: 104 MAEFDN-PNIVKLLGVC--AVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTR 160 Query: 134 ----------------RFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWG 177 ++ + Y +HRD+ N ++ E+ +++ D+G Sbjct: 161 ARVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVG-ENMVVKIADFG 219 Query: 178 LAEFYHPGQEYNVRVA---SRYFKGPELLVDYQMYDYSLDMWSLGCMLASMI-FRKEPFF 233 L+ + Y + PE + Y Y D+W+ G +L + + +P++ Sbjct: 220 LSRNIYSADYYKADGNDAIPIRWMPPESIF-YNRYTTESDVWAYGVVLWEIFSYGLQPYY 278 Query: 234 H-GHDNYDQLVRIAKVLGTED 253 H+ VR +L + Sbjct: 279 GMAHEEVIYYVRDGNILACPE 299 >5GNK-A nrPDB Length = 297 Score = 175 bits (443), Expect = 4e-44, Method: Composition-based stats. Identities = 50/278 (17%), Positives = 121/278 (43%), Gaps = 31/278 (11%) Query: 26 YESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKV----VVKILK----PVKKKK 77 ++ + +++ ++ LG G + V++ + I EKV +K L+ P K+ Sbjct: 8 PNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKE 67 Query: 78 IKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----LTDYDI 133 I E ++ ++ P++ L I ++ T L+ + + + + + Sbjct: 68 ILDEAYVMASVDN-PHVCRLLGIC---LTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYL 123 Query: 134 RFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFY-HPGQEYNVRV 192 + +I K ++Y ++HRD+ NV++ + +++ D+GLA+ +EY+ Sbjct: 124 LNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTP-QHVKITDFGLAKLLGAEEKEYHAEG 182 Query: 193 ASRY--FKGPELLVDYQMYDYSLDMWSLGCMLAS-MIFRKEPF--FHGHDNYDQLVRIAK 247 + E ++ +++Y + D+WS G + M F +P+ + L + + Sbjct: 183 GKVPIKWMALESIL-HRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGER 241 Query: 248 V----LGTEDLYDYIDKYNI---ELDPRFNDILGRHSR 278 + + T D+Y + K + + P+F +++ S+ Sbjct: 242 LPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSK 279 >1U59-A nrPDB Length = 287 Score = 174 bits (441), Expect = 6e-44, Method: Composition-based stats. Identities = 44/263 (16%), Positives = 105/263 (39%), Gaps = 30/263 (11%) Query: 44 KLGRGKYSEVFEAINITNNEK--VVVKILK----PVKKKKIKREIKILENLRGGPNIITL 97 +LG G + V + + ++ V +K+LK +++ RE +I+ L P I+ L Sbjct: 17 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDN-PYIVRL 75 Query: 98 ADIVKDPVSRTPALVFEHVNNTDFKQLY----QTLTDYDIRFYMYEILKALDYCHSMGIM 153 + + + LV E + + + ++ ++++ + Y + Sbjct: 76 IGVCQ---AEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFV 132 Query: 154 HRDVKPHNVMIDHEHRKLRLIDWGLAEFY-HPGQEYNVRVASRY---FKGPELLVDYQMY 209 HRD+ NV++ + H ++ D+GL++ Y R A ++ + PE + +++ + Sbjct: 133 HRDLAARNVLLVNRHYA-KISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI-NFRKF 190 Query: 210 DYSLDMWSLGCMLAS-MIFRKEPF--FHGHDNYDQLVRIAKVLGTEDLYDYIDK------ 260 D+WS G + + + ++P+ G + + + ++ + + Sbjct: 191 SSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCW 250 Query: 261 -YNIELDPRFNDILGRHSRKRWE 282 Y E P F + R + Sbjct: 251 IYKWEDRPDFLTVEQRMRACYYS 273 >4G3E-A nrPDB Length = 352 Score = 174 bits (440), Expect = 8e-44, Method: Composition-based stats. Identities = 48/227 (21%), Positives = 90/227 (39%), Gaps = 22/227 (9%) Query: 15 VNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK 74 +P +Y E V W ++GRG + EV + + VK ++ Sbjct: 59 TEKLKPVDYEYRE--EVHWMTHQP-----RVGRGSFGEVHRMKDKQTGFQCAVKKVR--- 108 Query: 75 KKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ---TLTDY 131 + + E + P I+ L V++ + E + QL + L + Sbjct: 109 LEVFRVEELVACAGLSSPRIVPLYGAVRE--GPWVNIFMELLEGGSLGQLIKQMGCLPED 166 Query: 132 DIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVR 191 +Y+ + L+ L+Y H+ I+H DVK NV++ + + L D+G A P Sbjct: 167 RALYYLGQALEGLEYLHTRRILHGDVKADNVLLSSDGSRAALCDFGHALCLQPDGLGKSL 226 Query: 192 V------ASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPF 232 + + PE+++ + D +D+WS CM+ M+ P+ Sbjct: 227 LTGDYIPGTETHMAPEVVMG-KPCDAKVDIWSSCCMMLHMLNGCHPW 272 >4Y93-A nrPDB Length = 446 Score = 173 bits (439), Expect = 9e-44, Method: Composition-based stats. Identities = 45/262 (17%), Positives = 109/262 (41%), Gaps = 28/262 (10%) Query: 35 NQDDYQLVRKLGRGKYSEVFEAINITNNEK-VVVKILK--PVKKKKIKREIKILENLRGG 91 + D +++LG G++ V + V +K++K + + + E K++ NL Sbjct: 186 DPKDLTFLKELGTGQFGVVKYGKWR--GQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHE 243 Query: 92 PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDY----DIRFYMYEILKALDYC 147 ++ L + R ++ E++ N + + + ++ +A++Y Sbjct: 244 K-LVQLYGVCTKQ--RPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYL 300 Query: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY---FKGPELLV 204 S +HRD+ N +++ + +++ D+G+ + EY S++ + PE+L+ Sbjct: 301 ESKQFLHRDLAARNCLVN-DQGVVKVSDFGMTRYVLDD-EYTSSTGSKFPVKWASPEVLM 358 Query: 205 DYQMYDYSLDMWSLGCMLASMIF-RKEPF--FHGHDNYDQLVRIAKV----LGTEDLYDY 257 Y + D+W+ G ++ + K P+ F + + + + ++ L +E +Y Sbjct: 359 -YSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLPRPHLASERVYAI 417 Query: 258 IDKYNIE---LDPRFNDILGRH 276 + E P F +L Sbjct: 418 MYSCWHEKADERPTFKILLSNI 439 >6B2Q-A nrPDB Length = 317 Score = 173 bits (439), Expect = 1e-43, Method: Composition-based stats. Identities = 51/209 (24%), Positives = 97/209 (46%), Gaps = 17/209 (8%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK------PVKKKKIKREIKILENLRGG 91 Y+L R + G +V+EA++ +V VK+LK P ++ + E + L Sbjct: 33 RYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAML-NH 91 Query: 92 PNIITLADIVKDPV---SRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALD 145 P I ++ D + + RT LV E VN + + L+ + + +AL Sbjct: 92 PGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQ 151 Query: 146 YCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH--PGQEYNVRVASRYFKGPELL 203 H+ G++HRDVKP N++I ++++ D+G+A+ P + + + + + PE Sbjct: 152 IAHAAGLVHRDVKPGNILIT-PTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQA 210 Query: 204 VDYQMYDYSLDMWSLGCMLASMIFRKEPF 232 + + + D++SLG + + K PF Sbjct: 211 LGHDA-SPASDVYSLGVVGYEAVSGKRPF 238 >4X3F-A nrPDB Length = 337 Score = 173 bits (439), Expect = 1e-43, Method: Composition-based stats. Identities = 51/209 (24%), Positives = 97/209 (46%), Gaps = 17/209 (8%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK------PVKKKKIKREIKILENLRGG 91 Y+L R + G +V+EA++ +V VK+LK P ++ + E + L Sbjct: 13 RYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAML-NH 71 Query: 92 PNIITLADIVKDPV---SRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALD 145 P I ++ D + + RT LV E VN + + L+ + + +AL Sbjct: 72 PGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQ 131 Query: 146 YCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH--PGQEYNVRVASRYFKGPELL 203 H+ G++HRDVKP N++I ++++ D+G+A+ P + + + + + PE Sbjct: 132 IAHAAGLVHRDVKPGNILIT-PTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQA 190 Query: 204 VDYQMYDYSLDMWSLGCMLASMIFRKEPF 232 + + + D++SLG + + K PF Sbjct: 191 LGHDA-SPASDVYSLGVVGYEAVSGKRPF 218 >4OW8-A nrPDB Length = 283 Score = 173 bits (439), Expect = 1e-43, Method: Composition-based stats. Identities = 51/209 (24%), Positives = 97/209 (46%), Gaps = 17/209 (8%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK------PVKKKKIKREIKILENLRGG 91 Y+L R + G +V+EA++ +V VK+LK P ++ + E + L Sbjct: 12 RYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAML-NH 70 Query: 92 PNIITLADIVKDPV---SRTPALVFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALD 145 P I ++ D + + RT LV E VN + + L+ + + +AL Sbjct: 71 PGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQ 130 Query: 146 YCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH--PGQEYNVRVASRYFKGPELL 203 H+ G++HRDVKP N++I ++++ D+G+A+ P + + + + + PE Sbjct: 131 IAHAAGLVHRDVKPGNILIT-PTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQA 189 Query: 204 VDYQMYDYSLDMWSLGCMLASMIFRKEPF 232 + + + D++SLG + + K PF Sbjct: 190 LGHDA-SPASDVYSLGVVGYEAVSGKRPF 217 >3ZBF-A nrPDB Length = 322 Score = 173 bits (438), Expect = 1e-43, Method: Composition-based stats. Identities = 54/288 (18%), Positives = 103/288 (35%), Gaps = 38/288 (13%) Query: 23 YWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAI-----NITNNE-KVVVKILKP---- 72 Y+ + ++ L LG G + EV+E + + E KV VK LK Sbjct: 19 YFQGSIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTD 78 Query: 73 VKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYD 132 +K + +E ++ PNI+ + ++ ++ E + D + Sbjct: 79 QEKIEFLKEAHLMSKF-NHPNILKQLGVC--LLNEPQYIILELMEGGDLLTYLRK--ARM 133 Query: 133 IRFY------------MYEILKALDYCHSMGIMHRDVKPHNVMIDHEH----RKLRLIDW 176 FY +I K Y M +HRD+ N ++ + R +++ D+ Sbjct: 134 ATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDF 193 Query: 177 GLAEFYHPGQEYNVRV---ASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFF 233 GLA + Y R + PE L+D ++ D+WS G ++ ++ + Sbjct: 194 GLARDIYKNDYYRKRGEGLLPVRWMAPESLMD-GIFTTQSDVWSFGILIWEILTLGHQPY 252 Query: 234 HGHDNYDQLVRIA---KVLGTEDLYDYIDKYNIELDPRFNDILGRHSR 278 H N D L + ++ + D + + + D R Sbjct: 253 PAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHR 300 >3LZB-A nrPDB Length = 327 Score = 173 bits (438), Expect = 1e-43, Method: Composition-based stats. Identities = 50/278 (17%), Positives = 121/278 (43%), Gaps = 31/278 (11%) Query: 26 YESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKV----VVKILK----PVKKKK 77 ++ + +++ ++ LG G + V++ + I EKV +K L+ P K+ Sbjct: 4 PNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKE 63 Query: 78 IKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----LTDYDI 133 I E ++ ++ P++ L I ++ T L+ + + + + + Sbjct: 64 ILDEAYVMASVDN-PHVCRLLGIC---LTSTVQLITQLMPFGCLLDYVREHKDNIGSQYL 119 Query: 134 RFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFY-HPGQEYNVRV 192 + +I K ++Y ++HRD+ NV++ + +++ D+GLA+ +EY+ Sbjct: 120 LNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTP-QHVKITDFGLAKLLGAEEKEYHAEG 178 Query: 193 ASRY--FKGPELLVDYQMYDYSLDMWSLGCMLAS-MIFRKEPFF--HGHDNYDQLVRIAK 247 + E ++ +++Y + D+WS G + M F +P+ + L + + Sbjct: 179 GKVPIKWMALESIL-HRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGER 237 Query: 248 V----LGTEDLYDYIDKYNI---ELDPRFNDILGRHSR 278 + + T D+Y + K + + P+F +++ S+ Sbjct: 238 LPQPPICTIDVYMIMRKCWMIDADSRPKFRELIIEFSK 275 >2OZO-A nrPDB Length = 613 Score = 172 bits (435), Expect = 3e-43, Method: Composition-based stats. Identities = 51/313 (16%), Positives = 121/313 (38%), Gaps = 41/313 (13%) Query: 4 PVPSRARVYTDVNTHRPREYWDYESHVVE---------WGNQDDYQLVR-KLGRGKYSEV 53 P P+R D P + +ES + + +D+ + +LG G + V Sbjct: 294 PEPARITS-PDKPRPMPMDTSVFESPFSDPEELKDKKLFLKRDNLLIADIELGCGNFGSV 352 Query: 54 FEAINITNNEK--VVVKILK----PVKKKKIKREIKILENLRGGPNIITLADIVKDPVSR 107 + + ++ V +K+LK +++ RE +I+ L P I+ L + + + Sbjct: 353 RQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDN-PYIVRLIGVCQ---AE 408 Query: 108 TPALVFEHVNNTDFKQLY----QTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVM 163 LV E + + + ++ ++++ + Y +HR++ NV+ Sbjct: 409 ALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRNLAARNVL 468 Query: 164 IDHEHRKLRLIDWGLAEFY-HPGQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLG 219 + + H ++ D+GL++ Y R A ++ + PE + +++ + D+WS G Sbjct: 469 LVNRHYA-KISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI-NFRKFSSRSDVWSYG 526 Query: 220 CMLAS-MIFRKEPF--FHGHDNYDQLVRIAKVLGTEDLYDYIDK-------YNIELDPRF 269 + + + ++P+ G + + + ++ + + Y E P F Sbjct: 527 VTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDF 586 Query: 270 NDILGRHSRKRWE 282 + R + Sbjct: 587 LTVEQRMRACYYS 599 >2BUJ-A nrPDB Length = 317 Score = 172 bits (435), Expect = 3e-43, Method: Composition-based stats. Identities = 65/332 (19%), Positives = 127/332 (38%), Gaps = 68/332 (20%) Query: 21 REYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL---KPVKKKK 77 RE ++ H+V N+ Y ++KLG G +S V + + +K + + +++ Sbjct: 14 RENLYFQGHMVIIDNK-HYLFIQKLGEGGFSYVDLVEGLHDGHFYALKRILCHEQQDREE 72 Query: 78 IKREIKILENLRGGPNIITLADIV--KDPVSRTPALVFEHVNNTDFKQLYQTL------- 128 +RE + L PNI+ L + L+ + L Sbjct: 73 AQREAD-MHRLFNHPNILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFL 131 Query: 129 TDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGL---------- 178 T+ I + + I + L+ H+ G HRD+KP N+++ E + + L+D G Sbjct: 132 TEDQILWLLLGICRGLEAIHAKGYAHRDLKPTNILLGDEGQPV-LMDLGSMNQACIHVEG 190 Query: 179 AEFYHPGQEYNVRVASRYFKGPEL--LVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGH 236 + Q++ + + ++ PEL + + + D D+WSLGC+L +M+F + P+ Sbjct: 191 SRQALTLQDWAAQRCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPYD--- 247 Query: 237 DNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPE 296 + G ++ +I PR + L + Sbjct: 248 --------MVFQKGDSVALAVQNQLSIPQSPRHSSALWQ--------------------- 278 Query: 297 ALDFLDKLLRYDHQSR------LTAREAMEHP 322 L+ ++ D R L+ EA++ P Sbjct: 279 ---LLNSMMTVDPHQRPHIPLLLSQLEALQPP 307 >5TE0-A nrPDB Length = 347 Score = 172 bits (435), Expect = 3e-43, Method: Composition-based stats. Identities = 68/379 (17%), Positives = 126/379 (33%), Gaps = 83/379 (21%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL---KPVKKKKIKREIKILENLRGGP 92 + + L G ++ VF +N K +K + + KREI+I+ +L G Sbjct: 18 RQQVTVDEVLAEGGFAIVFLVR-TSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHK 76 Query: 93 NIITLADIVKDPVSRTPA----LVFEHVNNT----DFKQLYQT-LTDYDIRFYMYEILKA 143 NI+ D + VS ++ + Q QT T+ ++ + +A Sbjct: 77 NIVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEA 136 Query: 144 LDYCHSMG--IMHRDVKPHNVMIDHEHRKLRLIDWGLA--EFYHPGQEYNVRV------- 192 + H I+HRD+K N+++ H+ L D+G A +F +P E V Sbjct: 137 VARLHQCKTPIIHRDLKVENILL-HDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKY 195 Query: 193 ASRYFKGPEL--LVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLG 250 + ++ PE+ L ++ D+W+LGC+L + + PF G Sbjct: 196 TTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPF-----------------G 238 Query: 251 TEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQ 310 + + I + R++ + + +L D Sbjct: 239 ESQVAICDGNFTIPDNSRYSQDMH------------------------CLIRYMLEPDPD 274 Query: 311 SRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLGPLAGS 370 R + YF S + P+ + + +P P A Sbjct: 275 KRPDIYQV---SYF-----------SFKLLKKECPIPNVQNSPIPAKLPEPVKASEAAAK 320 Query: 371 PVIAAANPLGMPVPAAAGA 389 A L P+P + Sbjct: 321 KTQPKA-RLTDPIPTTETS 338 >5AMN-A nrPDB Length = 299 Score = 172 bits (435), Expect = 3e-43, Method: Composition-based stats. Identities = 55/298 (18%), Positives = 120/298 (40%), Gaps = 47/298 (15%) Query: 36 QDDYQLVRKLGRGKYSEVFEA-----INITNNEKVVVKILK----PVKKKKIKREIKILE 86 + + L + LG G++ +V +A V VK+LK P + + + E +L+ Sbjct: 22 RKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLK 81 Query: 87 NLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ-------------TLTDYDI 133 + P++I L L+ E+ + + LT D+ Sbjct: 82 QV-NHPHVIKLYGACSQ--DGPLLLIVEYAKYGSLRGFLRESRKVGPGYPDERALTMGDL 138 Query: 134 RFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVA 193 + ++I + + Y M ++HRD+ N+++ E RK+++ D+GL+ + Y R Sbjct: 139 ISFAWQISQGMQYLAEMKLVHRDLAARNILV-AEGRKMKISDFGLSRDVYEEDSYVKRSQ 197 Query: 194 SRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLG 250 R + E L D+ +Y D+WS G +L ++ + G + Sbjct: 198 GRIPVKWMAIESLFDH-IYTTQSDVWSFGVLLWEIVTLGGNPYPG-------------IP 243 Query: 251 TEDLYDYIDKYNIELDPR-FNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRY 307 E L++ + + P ++ + R + W++ + + + + + D +K++ Sbjct: 244 PERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQ--EPDKRPVFADISKDL-EKMMVK 298 >5HVK-A nrPDB Length = 315 Score = 171 bits (433), Expect = 5e-43, Method: Composition-based stats. Identities = 47/313 (15%), Positives = 113/313 (36%), Gaps = 64/313 (20%) Query: 42 VRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK---IKREIKILENLRGGPNIITLA 98 LG+G + + + + E +V+K L ++ +E+K++ L PN++ Sbjct: 19 GEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEH-PNVLKFI 77 Query: 99 DIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDY----DIRFYMYEILKALDYCHSMGIMH 154 ++ + + E++ + + +++ + +I + Y HSM I+H Sbjct: 78 GVL--YKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIH 135 Query: 155 RDVKPHNVMIDHEHRKLRLIDWGLAEFYHPG---------------QEYNVRVASRYFKG 199 R++ HN ++ E++ + + D+GLA ++ V + Y+ Sbjct: 136 RNLNSHNCLV-RENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMA 194 Query: 200 PELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYID 259 PE++ + + YD +D++S G +L + I +V D Sbjct: 195 PEMI-NGRSYDEKVDVFSFGIVLCEI-------------------IGRVNADPDYLPRTM 234 Query: 260 KYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAM 319 + + + + + + + D + R + + + Sbjct: 235 DFGLNVRGFLDRYCPPNCPPSFFPITV----------------RCCDLDPEKRPSFVK-L 277 Query: 320 EHPYFYTVVKDQA 332 EH + T+ A Sbjct: 278 EH-WLETLRMHLA 289 >1K9A-A nrPDB Length = 450 Score = 170 bits (431), Expect = 9e-43, Method: Composition-based stats. Identities = 51/297 (17%), Positives = 107/297 (36%), Gaps = 55/297 (18%) Query: 35 NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK-KKIKREIKILENLRGGPN 93 N + +L++ +G+G++ +V KV VK +K + E ++ LR N Sbjct: 191 NMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQAFLAEASVMTQLRHS-N 247 Query: 94 IITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT-----LTDYDIRFYMYEILKALDYCH 148 ++ L ++ + +V E++ ++ L + + ++ +A++Y Sbjct: 248 LVQLLGVIVEEKGG-LYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE 306 Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQM 208 +HRD+ NV++ ++ ++ D+GL + Q+ + PE L + + Sbjct: 307 GNNFVHRDLAARNVLVSEDN-VAKVSDFGLTKEASSTQDTGKL--PVKWTAPEALRE-KK 362 Query: 209 YDYSLDMWSLGCMLASMI-FRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDP 267 + D+WS G +L + F + P+ Sbjct: 363 FSTKSDVWSFGILLWEIYSFGRVPY----------------------------------- 387 Query: 268 RFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT---AREAMEH 321 I + R E+ + P D + D +R T RE +EH Sbjct: 388 --PRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEH 442 >5U6B-A nrPDB Length = 307 Score = 169 bits (429), Expect = 1e-42, Method: Composition-based stats. Identities = 53/329 (16%), Positives = 110/329 (33%), Gaps = 77/329 (23%) Query: 41 LVRKLGRGKYSEVFEAINITNN--EKVVVKILK-----PVKKKKIKREIKILENLRGGPN 93 L + LG G++ V E ++ KV VK +K + + E ++ PN Sbjct: 27 LGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEF-DHPN 85 Query: 94 IITLADIV----KDPVSRTPALVFEHVNNTDFKQLYQT---------LTDYDIRFYMYEI 140 ++ L + + P ++ + + D L + +M +I Sbjct: 86 VMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADI 145 Query: 141 LKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY---F 197 ++Y + +HRD+ N M++ E+ + + D+GL++ + G Y ++ + Sbjct: 146 ASGMEYLSTKRFIHRDLAARNCMLN-ENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKW 204 Query: 198 KGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDN---YDQLVRIAKVLGTEDL 254 E L D ++Y D+WS G + + R + + G +N YD L + ++ D Sbjct: 205 IAIESLAD-RVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADC 263 Query: 255 YDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT 314 D + + + + Q R + Sbjct: 264 LDGLYA---------------------------------------LMSRCWELNPQDRPS 284 Query: 315 AREAMEHPYFYTVVKDQARMGSSSMPGGS 343 F + +D + P Sbjct: 285 ---------FTELREDLENTLKALPPAQE 304 >3PLS-A nrPDB Length = 298 Score = 169 bits (429), Expect = 2e-42, Method: Composition-based stats. Identities = 54/276 (19%), Positives = 110/276 (39%), Gaps = 29/276 (10%) Query: 43 RKLGRGKYSEVFEAINITNNE---KVVVKILKPV----KKKKIKREIKILENLRGGPNII 95 R +G+G + V+ I + + +K L + + + RE ++ L PN++ Sbjct: 27 RVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGL-NHPNVL 85 Query: 96 TLADIVKDPVSRTPALVFEHVNNTDFKQLYQTL----TDYDIRFYMYEILKALDYCHSMG 151 L I+ P L ++ + D Q ++ T D+ + ++ + ++Y Sbjct: 86 ALIGIMLPPEGLPHVL-LPYMCHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLAEQK 144 Query: 152 IMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVR-----VASRYFKGPELLVDY 206 +HRD+ N M+D E +++ D+GLA + Y+V+ + E L Y Sbjct: 145 FVHRDLAARNCMLD-ESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWTALESLQTY 203 Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQ---LVRIAKVLGTEDLYDYIDKYNI 263 + + D+WS G +L ++ R P + D +D L + ++ E D + + Sbjct: 204 R-FTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSLYQVMQ 262 Query: 264 ELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALD 299 + + R + E + +VS D Sbjct: 263 QCWEADPAVRPTF------RVLVGEVEQIVSALLGD 292 >4YFF-A nrPDB Length = 311 Score = 169 bits (429), Expect = 2e-42, Method: Composition-based stats. Identities = 43/266 (16%), Positives = 92/266 (34%), Gaps = 29/266 (10%) Query: 40 QLVRKLGRGKYSEVFEAINITNNEKVVVKI------LKPVKKKKIKREIKILENLRGGPN 93 + +G G + +V++ N+ V +K RE+ IL L P Sbjct: 45 EFHEIIGSGSFGKVYKGRCR--NKIVAIKRYRANTYCSKSDVDMFCREVSILCQL-NHPC 101 Query: 94 IITLADIVKDPVSRTPALVFEHVNNTDFKQLY----QTLTDYDIRFYMYEILKALDYCH- 148 +I + S+ A+V ++++ L + L ++ K ++Y H Sbjct: 102 VIQFVGACLNDPSQ-FAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLHN 160 Query: 149 -SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH--PGQEYNVRVASRYFKGPELLVD 205 + I+HRD+ HN+++ + + + D+G + F + + + PE+ Sbjct: 161 LTQPIIHRDLNSHNILLYEDGHAV-VADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQ 219 Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYN--- 262 Y D++S L ++ + PF H + Y + Sbjct: 220 CTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPISSLL 279 Query: 263 -------IELDPRFNDILGRHSRKRW 281 E P F++++ + Sbjct: 280 IRGWNACPEGRPEFSEVVMKLEECLC 305 >1BYG-A nrPDB Length = 278 Score = 167 bits (424), Expect = 5e-42, Method: Composition-based stats. Identities = 43/257 (16%), Positives = 101/257 (39%), Gaps = 24/257 (9%) Query: 35 NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK-KKIKREIKILENLRGGPN 93 N + +L++ +G+G++ +V KV VK +K + E ++ LR N Sbjct: 19 NMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQAFLAEASVMTQLRHS-N 75 Query: 94 IITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT-----LTDYDIRFYMYEILKALDYCH 148 ++ L ++ + +V E++ ++ L + + ++ +A++Y Sbjct: 76 LVQLLGVIVEEKGG-LYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE 134 Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQM 208 +HRD+ NV++ ++ ++ D+GL + Q+ + PE L + + Sbjct: 135 GNNFVHRDLAARNVLVSEDN-VAKVSDFGLTKEASSTQDTGKL--PVKWTAPEALRE-KK 190 Query: 209 YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVL-------GTEDLYDYIDKY 261 + D+WS G +L + + D + R+ K +Y+ + Sbjct: 191 FSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNC 250 Query: 262 ---NIELDPRFNDILGR 275 + + P F + + Sbjct: 251 WHLDAAMRPSFLQLREQ 267 >5VD3-A nrPDB Length = 311 Score = 167 bits (424), Expect = 5e-42, Method: Composition-based stats. Identities = 63/296 (21%), Positives = 107/296 (36%), Gaps = 54/296 (18%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKI-LKP----VKKKKIKREIKILENLRG 90 Q +Q + +LG G Y EVF+ + + VK + P + + E+ E + Sbjct: 56 QQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQ 115 Query: 91 GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ----TLTDYDIRFYMYEILKALDY 146 P + L ++ L E +Q + +L + + Y+ + L AL + Sbjct: 116 HPCCVRLEQAWEE--GGILYLQTELC-GPSLQQHCEAWGASLPEAQVWGYLRDTLLALAH 172 Query: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDY 206 HS G++H DVKP N+ + R +L D+GL V+ + PELL Sbjct: 173 LHSQGLVHLDVKPANIFLGPRGR-CKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGS 231 Query: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 266 Y + D++SLG + + E HG + + QL + Sbjct: 232 --YGTAADVFSLGLTILEVACNME-LPHGGEGWQQLRQG--------------------- 267 Query: 267 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHP 322 ++ E +S E L +L D + R TA + P Sbjct: 268 -----------------YLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALP 306 >3QUP-A nrPDB Length = 323 Score = 167 bits (424), Expect = 6e-42, Method: Composition-based stats. Identities = 55/303 (18%), Positives = 110/303 (36%), Gaps = 63/303 (20%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNE---KVVVKILK-----PVKKKKIKREIKILEN 87 + + L R LG+G++ V EA + KV VK+LK ++ RE ++ Sbjct: 22 EQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKE 81 Query: 88 LRGGPNIITLADIVKDPVSRT----PALVFEHVNNTDFKQLYQT---------LTDYDIR 134 P++ L + ++ P ++ + + D L + Sbjct: 82 F-DHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLV 140 Query: 135 FYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVAS 194 +M +I ++Y S +HRD+ N M+ E + + D+GL+ + G Y AS Sbjct: 141 RFMVDIACGMEYLSSRNFIHRDLAARNCML-AEDMTVCVADFGLSRKIYSGDYYRQGCAS 199 Query: 195 RY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGT 251 + + E L D +Y D+W+ G + ++ R + + G +N + Sbjct: 200 KLPVKWLALESLAD-NLYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEI---------- 248 Query: 252 EDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQS 311 +N ++G + K+ + E D + + D + Sbjct: 249 -----------------YNYLIGGNRLKQPPECM---------EEVYDLMYQCWSADPKQ 282 Query: 312 RLT 314 R + Sbjct: 283 RPS 285 >6FER-A nrPDB Length = 309 Score = 167 bits (424), Expect = 6e-42, Method: Composition-based stats. Identities = 57/305 (18%), Positives = 118/305 (38%), Gaps = 53/305 (17%) Query: 39 YQLVRKLGRGKYSEVFEA--------------INITNNE--KVVVKILK----PVKKKKI 78 KLG G++ EV ++++ N+ V VK+L+ + Sbjct: 11 LTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDF 70 Query: 79 KREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY------------- 125 +EIKI+ L+ PNII L + ++ E++ N D Q Sbjct: 71 LKEIKIMSRLKD-PNIIHLLAVC--ITDDPLCMITEYMENGDLNQFLSRHEPPNSSSSDV 127 Query: 126 QTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPG 185 +T++ +++F +I + Y S+ +HRD+ N ++ ++ +++ D+G++ + G Sbjct: 128 RTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVG-KNYTIKIADFGMSRNLYSG 186 Query: 186 QEYNVR---VASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQL 242 Y ++ V + E ++ + + D+W+ G L F Y QL Sbjct: 187 DYYRIQGRAVLPIRWMSWESIL-LGKFTTASDVWAFGVTLWETFT-----FCQEQPYSQL 240 Query: 243 VRIAKVLGTEDLYDYIDKYNIELDPR-FNDILGRHSRKRWERFVHSENQHLVSPEALDFL 301 + T + + + P D + + W R + ++ S + + L Sbjct: 241 SDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRR----DTKNRPSFQEIHLL 296 Query: 302 DKLLR 306 LL+ Sbjct: 297 --LLQ 299 >4TPT-A nrPDB Length = 303 Score = 167 bits (422), Expect = 1e-41, Method: Composition-based stats. Identities = 42/212 (19%), Positives = 92/212 (43%), Gaps = 32/212 (15%) Query: 42 VRKLGRGKYSEVFEAINITNNEKVVVKIL---KPVKKKKIKREIKILENLRGGPNIITLA 98 LG+G + + + + + +V+K L +K E+K++ +L PN++ Sbjct: 5 GEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSL-DHPNVLKFI 63 Query: 99 DIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDY---DIRFYMYEILKALDYCHSMGIMHR 155 ++ + L+ E++ K +++ + + I + Y HSM I+HR Sbjct: 64 GVL--YKDKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMAYLHSMCIIHR 121 Query: 156 DVKPHNVMIDHEHRKLRLIDWGLAEFY---------------------HPGQEYNVRVAS 194 D+ HN +I + + + + D+GL+ + ++ V + Sbjct: 122 DLNSHNCLIKLD-KTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGN 180 Query: 195 RYFKGPELLVDYQMYDYSLDMWSLGCMLASMI 226 Y+ PE+L + + YD ++D++S G +L +I Sbjct: 181 PYWMAPEML-NGKSYDETVDIFSFGIVLCEII 211 >5FM2-A nrPDB Length = 355 Score = 166 bits (420), Expect = 2e-41, Method: Composition-based stats. Identities = 55/312 (17%), Positives = 120/312 (38%), Gaps = 61/312 (19%) Query: 36 QDDYQLVRKLGRGKYSEVFEA-----INITNNEKVVVKILK----PVKKKKIKREIKILE 86 + + L + LG G++ +V +A V VK+LK P + + + E +L+ Sbjct: 63 RKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLK 122 Query: 87 NLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ-------------------- 126 + P++I L L+ E+ + + Sbjct: 123 QV-NHPHVIKLYGACSQ--DGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSS 179 Query: 127 -------TLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA 179 LT D+ + ++I + + Y M ++HRD+ N+++ E RK+++ D+GL+ Sbjct: 180 LDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILV-AEGRKMKISDFGLS 238 Query: 180 EFYHPGQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGH 236 + Y R R + E L D+ +Y D+WS G +L ++ + G Sbjct: 239 RDVYEEDSYVKRSQGRIPVKWMAIESLFDH-IYTTQSDVWSFGVLLWEIVTLGGNPYPG- 296 Query: 237 DNYDQLVRIAKVLGTEDLYDYIDKYNIELDPR-FNDILGRHSRKRWERFVHSENQHLVSP 295 + E L++ + + P ++ + R + W++ + + + + Sbjct: 297 ------------IPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQ--EPDKRPVFAD 342 Query: 296 EALDFLDKLLRY 307 + D +K++ Sbjct: 343 ISKDL-EKMMVK 353 >3I81-A nrPDB Length = 315 Score = 165 bits (419), Expect = 2e-41, Method: Composition-based stats. Identities = 51/289 (17%), Positives = 107/289 (37%), Gaps = 41/289 (14%) Query: 32 EWG-NQDDYQLVRKLGRGKYSEVFEAINI-----TNNEKVVVKILKPV----KKKKIKRE 81 EW ++ + R+LG+G + V+E + +V +K + ++ + E Sbjct: 12 EWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNE 71 Query: 82 IKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDY---------- 131 +++ +++ L +V + ++ E + D K ++L Sbjct: 72 ASVMKEFNCH-HVVRLLGVVSQ--GQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPP 128 Query: 132 ---DIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEY 188 + EI + Y ++ +HRD+ N M+ E +++ D+G+ + Y Sbjct: 129 SLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV-AEDFTVKIGDFGMTRDIYETDYY 187 Query: 189 NVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRI 245 + PE L D ++ D+WS G +L + E + G N L + Sbjct: 188 RKGGKGLLPVRWMSPESLKD-GVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFV 246 Query: 246 AK--VLGTED--------LYDYIDKYNIELDPRFNDILGRHSRKRWERF 284 + +L D L +YN ++ P F +I+ + F Sbjct: 247 MEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGF 295 >5IKW-A nrPDB Length = 310 Score = 165 bits (418), Expect = 3e-41, Method: Composition-based stats. Identities = 64/350 (18%), Positives = 121/350 (34%), Gaps = 81/350 (23%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKI---KREIKILENLRGGP 92 + L L G +S VF + +K + + KREI I++ L G Sbjct: 13 RHQVTLEESLAEGGFSTVFLVR-THGGIRCALKRMYVNNMPDLNVCKREITIMKELSGHK 71 Query: 93 NIITLADIVKDPVSRTPA---LVFEHVNNTDF-----KQLYQTLTDYDIRFYMYEILKAL 144 NI+ D + +S ++ E+ K+L T+ ++ + +A+ Sbjct: 72 NIVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAV 131 Query: 145 DYCHSMG--IMHRDVKPHNVMIDHEHRKLRLIDWGLA--EFYHPGQEYNVRV-------A 193 H I+HRD+K N++++ + L D+G A +F +P ++ V Sbjct: 132 ARLHQCKTPIIHRDLKVENILLN-DGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYT 190 Query: 194 SRYFKGPELLV--DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGT 251 + ++ PE++ + D+W+LGC+L + F PF G Sbjct: 191 TLSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPF-----------------GE 233 Query: 252 EDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQS 311 + + I + R++ + + +L D + Sbjct: 234 SQVAICDGNFTIPDNSRYSRNIH------------------------CLIRFMLEPDPEH 269 Query: 312 RLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTP 361 R + YF + PVS+ N S S++P P Sbjct: 270 RPDIFQV---SYF-----------AFKFAAADCPVSNINNSSIPSALPEP 305 >4HZS-A nrPDB Length = 341 Score = 165 bits (417), Expect = 3e-41, Method: Composition-based stats. Identities = 47/229 (20%), Positives = 87/229 (37%), Gaps = 23/229 (10%) Query: 36 QDDYQLVRKLGRGKYSEVFEAI-NITNNEKV--VVKILKP------VKKKKIKREIKILE 86 + D +L+ KLG G + V + + + V VK LKP RE+ + Sbjct: 11 EKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMH 70 Query: 87 NLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----LTDYDIRFYMYEILK 142 +L N+I L +V P + +V E + + Y ++ + Sbjct: 71 SL-DHRNLIRLYGVVLTPPMK---MVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAE 126 Query: 143 ALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNV----RVASRYFK 198 + Y S +HRD+ N+++ +++ D+GL ++ V R + Sbjct: 127 GMGYLESKRFIHRDLAARNLLLATRDL-VKIGDFGLMRALPQNDDHYVMQEHRKVPFAWC 185 Query: 199 GPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAK 247 PE L + + ++ D W G L M + + G + L +I K Sbjct: 186 APESL-KTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDK 233 >5U6C-A nrPDB Length = 315 Score = 164 bits (416), Expect = 5e-41, Method: Composition-based stats. Identities = 47/257 (18%), Positives = 103/257 (40%), Gaps = 29/257 (11%) Query: 35 NQDDYQLVRKLGRGKYSEVFEAINIT---NNEKVVVKILK-----PVKKKKIKREIKILE 86 +++ L + LG G++ V E + KV VK +K + ++ E ++ Sbjct: 34 DRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMK 93 Query: 87 NLRGGPNIITLADIVKDPVSR---TPALVFEHVNNTDFKQLY---------QTLTDYDIR 134 + PN++ L + + S+ P ++ + D + + + Sbjct: 94 DFSH-PNVMRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLL 152 Query: 135 FYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVAS 194 +M +I ++Y + +HRD+ N M+ + + + D+GL++ + G Y + Sbjct: 153 KFMVDIALGMEYLSNRNFLHRDLAARNCML-RDDMTVCVADFGLSKKIYSGDYYRQGRIA 211 Query: 195 RY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHG---HDNYDQLVRIAKV 248 + + E L D ++Y D+W+ G + + R + G H+ YD L+ ++ Sbjct: 212 KMPVKWIAIESLAD-RVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRL 270 Query: 249 LGTEDLYDYIDKYNIEL 265 ED D + + Sbjct: 271 KQPEDCLDELYEIMYSC 287 >3ZZW-A nrPDB Length = 289 Score = 164 bits (414), Expect = 8e-41, Method: Composition-based stats. Identities = 46/272 (16%), Positives = 104/272 (38%), Gaps = 39/272 (14%) Query: 40 QLVRKLGRGKYSEVFEAINI-----TNNEKVVVKILKPVK----KKKIKREIKILENLRG 90 + + +LG ++ +V++ + V +K LK +++ + E + L+ Sbjct: 12 RFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRARLQH 71 Query: 91 GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY-------------------QTLTDY 131 PN++ L +V + +++F + ++ D + L Sbjct: 72 -PNVVCLLGVVT--KDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPP 128 Query: 132 DIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVR 191 D + +I ++Y S ++H+D+ NV++ ++ +++ D GL + Y + Sbjct: 129 DFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLV-YDKLNVKISDLGLFREVYAADYYKLL 187 Query: 192 VASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAK- 247 S + PE ++ Y + D+WS G +L + + G+ N D + I Sbjct: 188 GNSLLPIRWMAPEAIM-YGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNR 246 Query: 248 --VLGTEDLYDYIDKYNIELDPRFNDILGRHS 277 + +D ++ IE F R Sbjct: 247 QVLPCPDDCPAWVYALMIECWNEFPSRRPRFK 278 >1U54-B nrPDB Length = 291 Score = 164 bits (414), Expect = 9e-41, Method: Composition-based stats. Identities = 47/229 (20%), Positives = 87/229 (37%), Gaps = 23/229 (10%) Query: 36 QDDYQLVRKLGRGKYSEVFEAI-NITNNEKV--VVKILKP------VKKKKIKREIKILE 86 + D +L+ KLG G + V + + + V VK LKP RE+ + Sbjct: 17 EKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMH 76 Query: 87 NLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----LTDYDIRFYMYEILK 142 +L N+I L +V P + +V E + + Y ++ + Sbjct: 77 SL-DHRNLIRLYGVVLTPPMK---MVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAE 132 Query: 143 ALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNV----RVASRYFK 198 + Y S +HRD+ N+++ +++ D+GL ++ V R + Sbjct: 133 GMGYLESKRFIHRDLAARNLLLATRDL-VKIGDFGLMRALPQNDDHYVMQEHRKVPFAWC 191 Query: 199 GPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAK 247 PE L + + ++ D W G L M + + G + L +I K Sbjct: 192 APESL-KTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDK 239 >3MDY-A nrPDB Length = 337 Score = 162 bits (410), Expect = 2e-40, Method: Composition-based stats. Identities = 65/301 (21%), Positives = 114/301 (37%), Gaps = 46/301 (15%) Query: 40 QLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILEN-LRGGPNIITLA 98 Q+V+++G+G+Y EV+ EKV VK+ ++ RE +I + L NI+ Sbjct: 40 QMVKQIGKGRYGEVWMGKWR--GEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFI 97 Query: 99 --DIVKDPVSRTPALVFEHVNNTDFKQLYQ--TLTDYDIRFYMYEILKALDYCH------ 148 DI L+ ++ N + TL + Y + L + H Sbjct: 98 AADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEIFST 157 Query: 149 --SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEY----NVRVASRYFKGPE 201 I HRD+K N+++ ++ + D GLA +F E N RV ++ + PE Sbjct: 158 QGKPAIAHRDLKSKNILV-KKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPE 216 Query: 202 LLVD------YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLY 255 +L + +Q Y DM+S G +L + R G + Y Sbjct: 217 VLDESLNRNHFQSY-IMADMYSFGLILWEVARRCV-----------------SGGIVEEY 258 Query: 256 DYIDKYNIELDPRFNDILGRHS-RKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT 314 + DP + D+ +K F + + + + + ++ SRLT Sbjct: 259 QLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLT 318 Query: 315 A 315 A Sbjct: 319 A 319 >5UIU-A nrPDB Length = 323 Score = 160 bits (405), Expect = 9e-40, Method: Composition-based stats. Identities = 42/203 (20%), Positives = 79/203 (38%), Gaps = 24/203 (11%) Query: 44 KLGRGKYSEVFEAINITNNEKVVVKIL-------KPVKKKKIKREIKILENLRGGPNIIT 96 K+G G + V++ NN V VK L K++ +EIK++ + N++ Sbjct: 54 KMGEGGFGVVYKGY--VNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQH-ENLVE 110 Query: 97 LADIVKDPVSRTPALVFEHVNNTDFKQLYQTLT-----DYDIRFYMYE-ILKALDYCHSM 150 L D V ++ N L + +R + + +++ H Sbjct: 111 LLGFSSDGDDLCLVYV--YMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHEN 168 Query: 151 GIMHRDVKPHNVMIDHEHRKLRLIDWGLAE---FYHPGQEYNVRVASRYFKGPELLVDYQ 207 +HRD+K N+++D E ++ D+GLA + + V + + PE L Sbjct: 169 HHIHRDIKSANILLD-EAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGE- 226 Query: 208 MYDYSLDMWSLGCMLASMIFRKE 230 D++S G +L +I Sbjct: 227 -ITPKSDIYSFGVVLLEIITGLP 248 >6DC0-A nrPDB Length = 292 Score = 159 bits (403), Expect = 1e-39, Method: Composition-based stats. Identities = 63/284 (22%), Positives = 108/284 (38%), Gaps = 52/284 (18%) Query: 53 VFEAINITNNEKVVVKILK-PVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPAL 111 V A+ I ++ K+ + KI+ I+ L NI IV+ + T A Sbjct: 22 VSRALCIHTGRELRCKVFPIKHYQDKIRPYIQ----LPSHSNI---TGIVEVILGETKAY 74 Query: 112 VFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEH 168 VF + D ++ L + + +I+ A+ +CH I+ D+K + E Sbjct: 75 VFFEKDFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEE 134 Query: 169 R-KLRLIDWGLAEFYH-PGQEYNVRVASRYFKGPELLVDYQMY-DYSLDMWSLGCMLASM 225 R +LRL + + + PE+L Y + D+WSLG ML ++ Sbjct: 135 RTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTL 194 Query: 226 IFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFV 285 + + PF +D S+ R +F Sbjct: 195 LVGRYPFHD-----------------------------------SDPSALFSKIRRGQFC 219 Query: 286 HSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 329 E+ +SP+A + LLR + RLTA E + HP+F +V++ Sbjct: 220 IPEH---ISPKARCLIRSLLRREPSERLTAPEILLHPWFESVLE 260 >5CEK-A nrPDB Length = 263 Score = 159 bits (403), Expect = 2e-39, Method: Composition-based stats. Identities = 63/284 (22%), Positives = 108/284 (38%), Gaps = 52/284 (18%) Query: 53 VFEAINITNNEKVVVKILK-PVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPAL 111 V A+ I ++ K+ + KI+ I+ L NI IV+ + T A Sbjct: 25 VSRALCIHTGRELRCKVFPIKHYQDKIRPYIQ----LPSHSNI---TGIVEVILGETKAY 77 Query: 112 VFEHVNNTDFKQLYQT---LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEH 168 VF + D ++ L + + +I+ A+ +CH I+ D+K + E Sbjct: 78 VFFEKDFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEE 137 Query: 169 R-KLRLIDWGLAEFYH-PGQEYNVRVASRYFKGPELLVDYQMY-DYSLDMWSLGCMLASM 225 R +LRL + + + PE+L Y + D+WSLG ML ++ Sbjct: 138 RTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTL 197 Query: 226 IFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFV 285 + + PF +D S+ R +F Sbjct: 198 LVGRYPFHD-----------------------------------SDPSALFSKIRRGQFC 222 Query: 286 HSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 329 E+ +SP+A + LLR + RLTA E + HP+F +V++ Sbjct: 223 IPEH---ISPKARCLIRSLLRREPSERLTAPEILLHPWFESVLE 263 >4NEU-A nrPDB Length = 333 Score = 157 bits (398), Expect = 6e-39, Method: Composition-based stats. Identities = 55/304 (18%), Positives = 111/304 (36%), Gaps = 43/304 (14%) Query: 28 SHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP-----VKKKKIKREI 82 S V D+ +L G + +V + T + +K + + + E Sbjct: 15 SLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMI-MKTVYKGPNCIEHNEALLEEA 73 Query: 83 KILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ---TLTDYDIRFYMYE 139 K++ LR ++ L ++ + + LV E++ + + + + + E Sbjct: 74 KMMNRLRHSR-VVKLLGVIIEEGKYS--LVMEYMEKGNLMHVLKAEMSTPLSVKGRIILE 130 Query: 140 ILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA--------------EFYHPG 185 I++ + Y H G++H+D+KP N+++D++ +++ D GLA E Sbjct: 131 IIEGMCYLHGKGVIHKDLKPENILVDND-FHIKIADLGLASFKMWSKLNNEEHNELREVD 189 Query: 186 QEYNVRVASRYFKGPELLVDYQ-MYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVR 244 + Y+ PE L D D++S +L ++ KEP+ + QL+ Sbjct: 190 GTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICE-QQLIM 248 Query: 245 IAKVLGTEDLYDY--------------IDKYNIELDPRFNDILGRHSRKRWERFVHSENQ 290 K D+ D + N E P F I + + S + Sbjct: 249 CIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEE 308 Query: 291 HLVS 294 + S Sbjct: 309 DVKS 312 >3Q4U-A nrPDB Length = 301 Score = 157 bits (397), Expect = 7e-39, Method: Composition-based stats. Identities = 59/312 (18%), Positives = 105/312 (33%), Gaps = 64/312 (20%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLR-GGPNIIT 96 D L+ +G+G+Y EV+ E V VKI +K RE ++ + NI+ Sbjct: 9 DITLLECVGKGRYGEVWRGSWQ--GENVAVKIFSSRDEKSWFRETELYNTVMLRHENILG 66 Query: 97 LA--DIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDI--RFYMYEILKALDYCH---- 148 D+ S L+ + Q T + + I L + H Sbjct: 67 FIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIF 126 Query: 149 ----SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE-----YNVRVASRYFKG 199 I HRD+K N+++ ++ + + D GLA + N RV ++ + Sbjct: 127 GTQGKPAIAHRDLKSKNILV-KKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMA 185 Query: 200 PELLVD------YQMYDYSLDMWSLGCMLASMIFR----------KEPFFHGHDNYDQLV 243 PE+L + + Y +D+W+ G +L + R K PF+ N Sbjct: 186 PEVLDETIQVDCFDSY-KRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFE 244 Query: 244 RIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDK 303 + KV+ + I ++ A + + Sbjct: 245 DMRKVVCVDQQRPNIPNRWFS-------------------------DPTLTSLAK-LMKE 278 Query: 304 LLRYDHQSRLTA 315 + +RLTA Sbjct: 279 CWYQNPSARLTA 290 >4M66-A nrPDB Length = 325 Score = 156 bits (394), Expect = 2e-38, Method: Composition-based stats. Identities = 56/225 (24%), Positives = 102/225 (45%), Gaps = 21/225 (9%) Query: 22 EYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKRE 81 + W + V ++++ + + +G+G + VF A + T N V VKI+ KKI E Sbjct: 5 KLWPTGASAVPLVSREELKKLEFVGKGGFGVVFRAHHRTWNHDVAVKIVNS---KKISWE 61 Query: 82 IKILENLRGGPNIITLADIVKDPVSRTP---ALVFEHVNNTDFKQLYQTLTDYD---IRF 135 +K + NLR N++ L + +D ALV + N L Q + Sbjct: 62 VKAMVNLRN-ENVLLLLGVTEDLQWDFVSGQALVTRFMENGSLAGLLQPEAPRPWPLLCR 120 Query: 136 YMYEILKALDYCHSMG--IMHRDVKPHNVMIDHEHRKLRLIDWGLAEF-------YHPGQ 186 + E++ + Y HS+ ++HRD+KP N+++D E +L D+GL+ F G Sbjct: 121 LLQEVVLGMCYLHSLDPPLLHRDLKPSNILLDPELHA-KLADFGLSTFQGGSQSGSGSGS 179 Query: 187 EYNVRVASRYFKGPELLVDYQ-MYDYSLDMWSLGCMLASMIFRKE 230 + + PELL + D++S G ++ +++ +E Sbjct: 180 GSRDSGGTLAYLDPELLFKVNLKASKASDVYSFGILVWAVLAGRE 224 >5L2Q-C nrPDB Length = 320 Score = 155 bits (393), Expect = 2e-38, Method: Composition-based stats. Identities = 49/311 (15%), Positives = 101/311 (32%), Gaps = 80/311 (25%) Query: 54 FEAINITNNEKVVVKILKPVKKKK--------------IKREIKILENLRGGPNIITLAD 99 A ++ +KIL ++ + E +L L ++ Sbjct: 33 CLARKDGTDDFYQLKILTLEERGDQGIESQEERQGKMLLHTEYSLLSLLHTQDGVVHHHG 92 Query: 100 IVKD----------------PVSRTPALVFEHVNNTDFKQL-------------YQTLTD 130 + +D + + LV + + DF + L++ Sbjct: 93 LFQDRTCEIVEDTESSRMVKKMKKRICLVLDCLCAHDFSDKTADLINLQHYVIKEKRLSE 152 Query: 131 YDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE-FYHPGQEYN 189 + Y++++ ++ H I+HRD+K N++++ ++ + ++ L + G Sbjct: 153 RETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEGDLLK 212 Query: 190 VRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVL 249 + S + P++L DMW+LG +L +M++ + PF+ Sbjct: 213 DQRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPFYD--------------- 257 Query: 250 GTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDH 309 I RK VS + + KLL D Sbjct: 258 ---------------------SIPQELFRKIKAAEYTIPEDGRVSENTVCLIRKLLVLDP 296 Query: 310 QSRLTAREAME 320 Q RL A + +E Sbjct: 297 QQRLAAADVLE 307 >5TOS-A nrPDB Length = 395 Score = 155 bits (393), Expect = 3e-38, Method: Composition-based stats. Identities = 63/357 (17%), Positives = 120/357 (33%), Gaps = 60/357 (16%) Query: 38 DYQLVRKLGRGKYSEVFEA---------INITNNEKVVVKILKP---VKKKKIKREIKIL 85 +++ +G G + VF+ + VK L ++ EI L Sbjct: 66 NFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYL 125 Query: 86 ENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY-------QTLTDYDIRFYMY 138 L PN++ L + R LV+E + + + L + Sbjct: 126 GQLSH-PNLVKLIGYCLEDEHR--LLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVAL 182 Query: 139 EILKALDYCHS--MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF--YHPGQEYNVRV-A 193 + K L + HS + +++RD+K N+++D ++ +L D+GLA + RV Sbjct: 183 DAAKGLAFLHSDPVKVIYRDIKASNILLDADYNA-KLSDFGLARDGPMGDLSYVSTRVMG 241 Query: 194 SRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTED 253 + + PE + + D++S G +L ++ K H + E+ Sbjct: 242 TYGYAAPEYM-SSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKE-----------EN 289 Query: 254 LYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRL 313 L D+ Y + R + V + L ++ +SR Sbjct: 290 LVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAV---------QCLSFEPKSRP 340 Query: 314 TARE---AMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVP--TPSPLG 365 T + A++ ++D S + P T + SS T P G Sbjct: 341 TMDQVVRALQ------QLQDNLGKPSQTNPVKDTKKLGFKTGTTKSSEKRFTQKPFG 391 >4LQP-A nrPDB Length = 508 Score = 155 bits (392), Expect = 3e-38, Method: Composition-based stats. Identities = 44/198 (22%), Positives = 87/198 (43%), Gaps = 14/198 (7%) Query: 1 MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINIT 60 ++ S R +++ +E + + +D+ V+ +G+G + EV Sbjct: 67 LTSHNWSEERKSRQLSSLGKKE-SQFLRLRRTRLSLEDFHTVKVIGKGAFGEVRLVQKKD 125 Query: 61 NNEKVVVKIL------KPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFE 114 + +K L K + +K E +L P +++L +D ++ L+ E Sbjct: 126 TGKIYAMKTLLKSEMYKKDQLAHVKAERDVLAG-SDSPWVVSLYYSFQD--AQYLYLIME 182 Query: 115 HVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKL 171 + D + Q T+ RFYM E + A++ H +G +HR +KP N++ID + Sbjct: 183 FLPGGDLMTMLIRWQLFTEDVTRFYMAECILAIETIHKLGFIHRAIKPDNILIDIRGH-I 241 Query: 172 RLIDWGLAEFYHPGQEYN 189 +L D+GL+ +H + N Sbjct: 242 KLSDFGLSTGFHKTHDSN 259 Score = 99.7 bits (247), Expect = 2e-21, Method: Composition-based stats. Identities = 39/205 (19%), Positives = 65/205 (31%), Gaps = 46/205 (22%) Query: 190 VRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVL 249 V + + PE+ + YQ Y D WSLG ++ + PF + +I Sbjct: 322 STVGTPDYIAPEIFL-YQGYGQECDWWSLGAIMYECLIGWPPFCS-ETPQETYRKIMNFE 379 Query: 250 GTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDH 309 T D I +S EA D + +LL + Sbjct: 380 QTLQFPDDIH---------------------------------ISYEAEDLIRRLLTH-A 405 Query: 310 QSRL----TAREAMEHPYFYTVVKDQAR-MGSSSMPGGSTPVSSANM-MSGISSVPTPSP 363 RL A E HP+F V + R + + +P S+ + + +VP Sbjct: 406 DQRLGRHGGADEIKSHPFFRGVDWNTIRQVEAPYIPKLSSITDTRFFPTDELENVPDSPA 465 Query: 364 LGPLAGS----PVIAAANPLGMPVP 384 + A + P+ +P Sbjct: 466 MAQAAKQREQMTKQGGSAPVKEDLP 490 >3MY0-A nrPDB Length = 305 Score = 155 bits (391), Expect = 4e-38, Method: Composition-based stats. Identities = 66/309 (21%), Positives = 111/309 (35%), Gaps = 64/309 (20%) Query: 41 LVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILEN-LRGGPNIITLA- 98 LV +G+G+Y EV+ + + E V VKI ++ RE +I L NI+ Sbjct: 12 LVECVGKGRYGEVWRGLW--HGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIA 69 Query: 99 -DIVKDPVSRTPALVFEHVNNTDFKQLY--QTLTDYDIRFYMYEILKALDYCH------- 148 D+ S L+ + + QTL + L + H Sbjct: 70 SDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEIFGTQ 129 Query: 149 -SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEY-----NVRVASRYFKGPEL 202 I HRD K NV++ + + + D GLA + G +Y N RV ++ + PE+ Sbjct: 130 GKPAIAHRDFKSRNVLVKS-NLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEV 188 Query: 203 LVD------YQMYDYSLDMWSLGCMLASMIFR----------KEPFFHGHDNYDQLVRIA 246 L + ++ Y D+W+ G +L + R + PF+ N + Sbjct: 189 LDEQIRTDCFESY-KWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFEDMK 247 Query: 247 KVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLR 306 KV+ + I + DP + L + R+ W Sbjct: 248 KVVCVDQQTPTIPN-RLAADPVLSG-LAQMMRECWYP----------------------- 282 Query: 307 YDHQSRLTA 315 + +RLTA Sbjct: 283 -NPSARLTA 290 >1PY5-A nrPDB Length = 326 Score = 152 bits (385), Expect = 2e-37, Method: Composition-based stats. Identities = 48/274 (17%), Positives = 103/274 (37%), Gaps = 38/274 (13%) Query: 41 LVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLR-GGPNIITLA- 98 L +G+G++ EV+ E+V VKI +++ RE +I + + NI+ Sbjct: 33 LQESIGKGRFGEVWRGKWR--GEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIA 90 Query: 99 -DIVKDPVSRTPALVFEHVNNTDFKQLYQ--TLTDYDIRFYMYEILKALDYCH------- 148 D + LV ++ + T+T + L + H Sbjct: 91 ADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQ 150 Query: 149 -SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEY-----NVRVASRYFKGPEL 202 I HRD+K N+++ ++ + D GLA + + N RV ++ + PE+ Sbjct: 151 GKPAIAHRDLKSKNILV-KKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEV 209 Query: 203 L---VDYQMYD--YSLDMWSLGCMLASMIFRKE----------PFFHGHDNYDQLVRIAK 247 L ++ + ++ D++++G + + R P++ + + + K Sbjct: 210 LDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRK 269 Query: 248 VLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRW 281 V+ + L I ++ + R+ W Sbjct: 270 VVCEQKLRPNIPNRWQSC--EALRVMAKIMRECW 301 >3AOX-A nrPDB Length = 344 Score = 152 bits (385), Expect = 2e-37, Method: Composition-based stats. Identities = 50/275 (18%), Positives = 93/275 (33%), Gaps = 38/275 (13%) Query: 36 QDDYQLVRKLGRGKYSEVFEAI-----NITNNEKVVVKILKPVKKKK----IKREIKILE 86 + + L+R LG G + EV+E N + +V VK L V ++ E I+ Sbjct: 46 RKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIIS 105 Query: 87 NLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ----------TLTDYDIRFY 136 NI+ + S ++ E + D K + +L D+ Sbjct: 106 KF-NHQNIVRCIGV--SLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHV 162 Query: 137 MYEILKALDYCHSMGIMHRDVKPHNVMID--HEHRKLRLIDWGLAEFYHPGQEYNVRVAS 194 +I Y +HRD+ N ++ R ++ D+G+A + Y + Sbjct: 163 ARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCA 222 Query: 195 RY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGT 251 + PE ++ ++ D WS G +L + + N + L + Sbjct: 223 MLPVKWMPPEAFME-GIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRM 281 Query: 252 EDLYDYID----------KYNIELDPRFNDILGRH 276 + + ++ E P F IL R Sbjct: 282 DPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERI 316 >4F0G-A nrPDB Length = 287 Score = 152 bits (383), Expect = 3e-37, Method: Composition-based stats. Identities = 47/271 (17%), Positives = 111/271 (40%), Gaps = 34/271 (12%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP----------VKKKKIKREIKILE 86 ++ + +++G+G + V + + + V +K L K ++ +RE+ I+ Sbjct: 19 NEIEYEKQIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQREVFIMS 78 Query: 87 NLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY----QTLTDYDIRFYMYEILK 142 NL PNI+ L ++ +P +V E V D + M +I Sbjct: 79 NL-NHPNIVKLYGLMHNPPR----MVMEFVPCGDLYHRLLDKAHPIKWSVKLRLMLDIAL 133 Query: 143 ALDYCHSMG--IMHRDVKPHNVMIDH--EHRKL--RLIDWGLAEFYHPGQEYNVRVASRY 196 ++Y + I+HRD++ N+ + E+ + ++ D+GL++ + + + Sbjct: 134 GIEYMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQ--QSVHSVSGLLGNFQ 191 Query: 197 FKGPELL-VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLY 255 + PE + + + Y D +S +L +++ + PF + ++ ++ E L Sbjct: 192 WMAPETIGAEEESYTEKADTYSFAMILYTILTGEGPF---DEYSYGKIKFINMIREEGLR 248 Query: 256 DYIDKYNIELDPRFNDILGRHSRKRWERFVH 286 I + + PR +++ ++ H Sbjct: 249 PTIPE---DCPPRLRNVIELCWSGDPKKRPH 276 >5WNL-A nrPDB Length = 342 Score = 151 bits (382), Expect = 4e-37, Method: Composition-based stats. Identities = 56/344 (16%), Positives = 135/344 (39%), Gaps = 57/344 (16%) Query: 43 RKLGRGKYSEVFEAINITNNEKVVVKI-----LKPVKKKKIKREIKILENLRGGPNIITL 97 K+G G + +V++ ++ + +K + ++ ++ E K +E + I+ + Sbjct: 26 EKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRERMELLEEAKKMEMAK-FRYILPV 84 Query: 98 ADIVKDPVSRTPALVFEHVNNTDFKQLYQTLT-DYDIRF-YMYEILKALDYCHSMG--IM 153 I ++PV LV E++ ++L + +D+RF ++E +++ H M ++ Sbjct: 85 YGICQEPVG----LVMEYMETGSLEKLLASEPLPWDLRFRIVHETAVGMNFLHCMSPPLL 140 Query: 154 HRDVKPHNVMIDHEHRKLRLIDWGLAEF----YHPGQEYNVRVASRYFKGPELLVD-YQM 208 H ++KP N+++D H +++ D+GLA+ + + + + PE + + ++ Sbjct: 141 HLNLKPANILLDA-HYHVKISDFGLAKCNGMSHSHDLSMDGLFGTIAYLPPERIREKSRL 199 Query: 209 YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPR 268 +D D++S ++ ++ +K+PF + ++++ K P Sbjct: 200 FDTKHDVYSFAIVIWGVLTQKKPFADEKNILHIMMKVVKG----------------HRPE 243 Query: 269 FNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVV 328 I R + + + D Q R T +E + Sbjct: 244 LPPICRPRPRAC--------------ASLIGLMQRCWHADPQVRPTFQE------ITSET 283 Query: 329 KDQARMGSSSMPGGS-TPVSSANMMSGISSVPTPSPLGPLAGSP 371 +D + + P +++ S + P S L + P Sbjct: 284 EDLCEKPDEEVKDLAHEPGEKSSLESKSEARPESSRLKRASAPP 327 >3UIM-A nrPDB Length = 326 Score = 151 bits (382), Expect = 4e-37, Method: Composition-based stats. Identities = 50/243 (20%), Positives = 94/243 (38%), Gaps = 26/243 (10%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK----KIKREIKILENLRGGP 92 D++ LGRG + +V++ + + V VK LK + + + + E++++ Sbjct: 30 DNFSNKNILGRGGFGKVYKGR-LADGTLVAVKRLKEERTQGGELQFQTEVEMISMAVH-R 87 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYD-------IRFYMYEILKALD 145 N++ L P R LV+ ++ N + + + + L Sbjct: 88 NLLRLRGFCMTPTER--LLVYPYMANGSVASCLRERPESQPPLDWPKRQRIALGSARGLA 145 Query: 146 YCHSM---GIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF--YHPGQEYNVRVASRYFKGP 200 Y H I+HRDVK N+++D E + + D+GLA+ Y + P Sbjct: 146 YLHDHCDPKIIHRDVKAANILLDEEFEAV-VGDFGLAKLMDYKDTHVTTAVRGTIGHIAP 204 Query: 201 ELLVDYQMYDYSLDMWSLGCMLASMIFRKEPF----FHGHDNYDQLVRIAKVLGTEDLYD 256 E L + D++ G ML +I + F D+ L + +L + L Sbjct: 205 EYLSTGKS-SEKTDVFGYGVMLLELITGQRAFDLARLANDDDVMLLDWVKGLLKEKKLEA 263 Query: 257 YID 259 +D Sbjct: 264 LVD 266 >6J5U-C nrPDB Length = 426 Score = 151 bits (381), Expect = 5e-37, Method: Composition-based stats. Identities = 69/369 (18%), Positives = 127/369 (34%), Gaps = 61/369 (16%) Query: 38 DYQLVRKLGRGKYSEVFEAINITN---------NEKVVVKILKP---VKKKKIKREIKIL 85 +++ LG G + VF+ V VK LKP K+ E+ L Sbjct: 85 NFRQDNLLGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQLKPEGFQGHKEWLTEVNYL 144 Query: 86 ENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY-----QTLTDYDIRFYMYEI 140 L PN++ L + +R LV+E + + Q LT Sbjct: 145 GQLSH-PNLVLLVGYCAEGENR--LLVYEFMPKGSLENHLFRRGAQPLTWAIRMKVAVGA 201 Query: 141 LKALDYCHSMG--IMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVR---VASR 195 K L + H +++RD K N+++D + +L D+GLA+ G +V + + Sbjct: 202 AKGLTFLHEAKSQVIYRDFKAANILLDAD-FNAKLSDFGLAKAGPTGDNTHVSTKVIGTH 260 Query: 196 YFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLY 255 + PE + ++ D++S G +L +I + DN + L Sbjct: 261 GYAAPEYVATGRL-TAKSDVYSFGVVLLELISGR----RAMDN-------SNGGNEYSLV 308 Query: 256 DYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTA 315 D+ Y + F + + + ++ + A + + L D + R Sbjct: 309 DWATPYLGDKRKLFRIMDTKLGGQYPQKGAFT---------AANLALQCLNPDAKLRPKM 359 Query: 316 REAM----EHPYFYTVVKDQARMGSSSMPG-------GSTPVSSANMMSGISSVPTPSPL 364 E + + +V K + P +PV ++ + P SPL Sbjct: 360 SEVLVTLEQ---LESVAKPGTKHTQMESPRFHHSSVMQKSPVRYSHDRPLLHMTPGASPL 416 Query: 365 GPLAGSPVI 373 SP + Sbjct: 417 PSYTQSPRV 425 >3G2F-A nrPDB Length = 336 Score = 150 bits (380), Expect = 7e-37, Method: Composition-based stats. Identities = 57/310 (18%), Positives = 111/310 (35%), Gaps = 45/310 (14%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILEN-LRGGPNII 95 D+ +L+ +GRG+Y V++ + V VK+ ++ E I L NI Sbjct: 13 DNLKLLELIGRGRYGAVYKG--SLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIA 70 Query: 96 TLA---DIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIR--FYMYEILKALDYCH-- 148 + V LV E+ N + T + + + + L Y H Sbjct: 71 RFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTE 130 Query: 149 -------SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA------EFYHPGQEYN---VRV 192 I HRD+ NV++ ++ + + D+GL+ PG+E N V Sbjct: 131 LPRGDHYKPAISHRDLNSRNVLVKNDGTCV-ISDFGLSMRLTGNRLVRPGEEDNAAISEV 189 Query: 193 ASRYFKGPELLVD------YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIA 246 + + PE+L + +DM++LG + + R F G + + Sbjct: 190 GTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVPEYQMAFQ 249 Query: 247 KVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLR 306 +G ++ + +L ++R + + L + ++ Sbjct: 250 TEVGNHPTFEDM------------QVLVSREKQRPKFPEAWKENSLAVRSLKETIEDCWD 297 Query: 307 YDHQSRLTAR 316 D ++RLTA+ Sbjct: 298 QDAEARLTAQ 307 >5LPZ-A nrPDB Length = 332 Score = 150 bits (378), Expect = 1e-36, Method: Composition-based stats. Identities = 51/256 (19%), Positives = 100/256 (39%), Gaps = 22/256 (8%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK---KIKREIKILENLRGGPNII 95 + +G G + +V++AI + V +K L V + + E++ + ++ N++ Sbjct: 19 FHNDSLIGSGGFGDVYKAILK-DGSAVAIKKLIHVSGQGDREFMAEMETIGKIKH-RNLV 76 Query: 96 TLADIVKDPVSRTPALVFEHVNNTDFKQLYQ-------TLTDYDIRFYMYEILKALDYCH 148 L K V LV+E + + + L R + L + H Sbjct: 77 PLLGYCK--VGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLH 134 Query: 149 SM---GIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEY---NVRVASRYFKGPEL 202 I+HRD+K NV++D E+ + R+ D+G+A + + + + PE Sbjct: 135 HNCSPHIIHRDMKSSNVLLD-ENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEY 193 Query: 203 LVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYN 262 ++ D++S G +L ++ K P + LV K + D D Sbjct: 194 YQSFR-CSTKGDVYSYGVVLLELLTGKRPTDSPDFGDNNLVGWVKQHAKLRISDVFDPEL 252 Query: 263 IELDPRFNDILGRHSR 278 ++ DP L +H + Sbjct: 253 MKEDPALEIELLQHLK 268 >5C26-A nrPDB Length = 299 Score = 150 bits (378), Expect = 1e-36, Method: Composition-based stats. Identities = 60/298 (20%), Positives = 121/298 (40%), Gaps = 42/298 (14%) Query: 11 VYTDVNTHRPRE-YWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAIN--ITNNEKVVV 67 Y D RP+E Y D + +E ++LG G + V + + V V Sbjct: 9 PYADPEEIRPKEVYLDRKLLTLE---------DKELGSGNFGTVKKGYYQMKKVVKTVAV 59 Query: 68 KILK-----PVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFK 122 KILK P K ++ E +++ L P I+ + I + + + LV E Sbjct: 60 KILKNEANDPALKDELLAEANVMQQLDN-PYIVRMIGICE---AESWMLVMEMAELGPLN 115 Query: 123 QLYQT---LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA 179 + Q + D +I ++++ + Y +HRD+ NV++ +H ++ D+GL+ Sbjct: 116 KYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYA-KISDFGLS 174 Query: 180 EFYHPGQE-YNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMI-FRKEPF-- 232 + + Y + ++ + PE + +Y + D+WS G ++ + ++P+ Sbjct: 175 KALRADENYYKAQTHGKWPVKWYAPECI-NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRG 233 Query: 233 FHGHDNYDQLVRIAKVLGTE--------DLYDYIDKYNIELDPRFNDILGRHSRKRWE 282 G + L + + +G DL + Y++E P F + R ++ Sbjct: 234 MKGSEVTAMLEKGER-MGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYD 290 >4FL3-A nrPDB Length = 635 Score = 150 bits (378), Expect = 1e-36, Method: Composition-based stats. Identities = 59/298 (19%), Positives = 121/298 (40%), Gaps = 42/298 (14%) Query: 11 VYTDVNTHRPRE-YWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAIN--ITNNEKVVV 67 + D RP+E Y D + +E ++LG G + V + + V V Sbjct: 351 PFADPEEIRPKEVYLDRKLLTLE---------DKELGSGNFGTVKKGYYQMKKVVKTVAV 401 Query: 68 KILK-----PVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFK 122 KILK P K ++ E +++ L P I+ + I + + + LV E Sbjct: 402 KILKNEANDPALKDELLAEANVMQQLDN-PYIVRMIGICE---AESWMLVMEMAELGPLN 457 Query: 123 QLYQT---LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA 179 + Q + D +I ++++ + Y +HRD+ NV++ +H ++ D+GL+ Sbjct: 458 KYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYA-KISDFGLS 516 Query: 180 EFYHPGQE-YNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMI-FRKEPF-- 232 + + Y + ++ + PE + +Y + D+WS G ++ + ++P+ Sbjct: 517 KALRADENYYKAQTHGKWPVKWYAPECI-NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRG 575 Query: 233 FHGHDNYDQLVRIAKVLGTE--------DLYDYIDKYNIELDPRFNDILGRHSRKRWE 282 G + L + + +G DL + Y++E P F + R ++ Sbjct: 576 MKGSEVTAMLEKGER-MGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYD 632 >5LPV-A nrPDB Length = 296 Score = 149 bits (376), Expect = 2e-36, Method: Composition-based stats. Identities = 51/256 (19%), Positives = 101/256 (39%), Gaps = 22/256 (8%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK---KIKREIKILENLRGGPNII 95 + +G G + +V++AI + + V +K L V + + E++ + ++ N++ Sbjct: 19 FHNDSLIGSGGFGDVYKAI-LKDGSAVAIKKLIHVSGQGDREFMAEMETIGKIKH-RNLV 76 Query: 96 TLADIVKDPVSRTPALVFEHVNNTDFKQLYQ-------TLTDYDIRFYMYEILKALDYCH 148 L K V LV+E + + + L R + L + H Sbjct: 77 PLLGYCK--VGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLH 134 Query: 149 SM---GIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEY---NVRVASRYFKGPEL 202 I+HRD+K NV++D E+ + R+ D+G+A + + + + PE Sbjct: 135 HNCSPHIIHRDMKSSNVLLD-ENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEY 193 Query: 203 LVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYN 262 ++ D++S G +L ++ K P + LV K + D D Sbjct: 194 YQSFR-CSTKGDVYSYGVVLLELLTGKRPTDSPDFGDNNLVGWVKQHAKLRISDVFDPEL 252 Query: 263 IELDPRFNDILGRHSR 278 ++ DP L +H + Sbjct: 253 MKEDPALEIELLQHLK 268 >2H34-A nrPDB Length = 309 Score = 149 bits (376), Expect = 2e-36, Method: Composition-based stats. Identities = 50/221 (22%), Positives = 97/221 (43%), Gaps = 16/221 (7%) Query: 23 YWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK------PVKKK 76 + D + E Y+L R +GRG +V+EA + V +K++ PV + Sbjct: 20 HMDGTAESREGTQFGPYRLRRLVGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPVFRT 79 Query: 77 KIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT---LTDYDI 133 +++RE + L+ P+++ + D + + + +N D + + L Sbjct: 80 RMQREARTAGRLQ-EPHVVPIHDFGE--IDGQLYVDMRLINGVDLAAMLRRQGPLAPPRA 136 Query: 134 RFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ--EYNVR 191 + +I ALD H+ G HRDVKP N+++ + L+D+G+A + + Sbjct: 137 VAIVRQIGSALDAAHAAGATHRDVKPENILVSADDFAY-LVDFGIASATTDEKLTQLGNT 195 Query: 192 VASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPF 232 V + Y+ PE + Y D+++L C+L + P+ Sbjct: 196 VGTLYYMAPERFSESHA-TYRADIYALTCVLYECLTGSPPY 235 >3QD2-B nrPDB Length = 332 Score = 147 bits (372), Expect = 5e-36, Method: Composition-based stats. Identities = 60/344 (17%), Positives = 119/344 (34%), Gaps = 102/344 (29%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK----PVKKKKIKREIKILENLRGGPN 93 D++ ++ +GRG + VFEA N ++ +K ++ + ++K+ RE+K L L P Sbjct: 7 DFEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEH-PG 65 Query: 94 I---------------------ITLADIVKD----------------------------- 103 I I L D D Sbjct: 66 IVRYFNAWLETPPEKWQEEMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFSTKNTVG 125 Query: 104 -----PVSRTPALVFEHVNNTDFKQLYQ---TLTDYD---IRFYMYEILKALDYCHSMGI 152 + + + K +L D + +I +A+++ HS G+ Sbjct: 126 QLQPSSPKVYLYIQMQLCRKENLKDWMNRRCSLEDREHGVCLHIFIQIAEAVEFLHSKGL 185 Query: 153 MHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE-------------YNVRVASRYFKG 199 MHRD+KP N+ + +++ D+GL +E + +V ++ + Sbjct: 186 MHRDLKPSNIFFTMDD-VVKVGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQVGTKLYMS 244 Query: 200 PELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYID 259 PE + Y + +D++SLG +L +++ Q+ R+ + D Sbjct: 245 PEQIHGNN-YSHKVDIFSLGLILFELLY---------SFSTQMERVRII---------TD 285 Query: 260 KYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDK 303 N++ F + + S + PEA D ++ Sbjct: 286 VRNLKFPLLFTQKYPQEHMMVQDMLSPSPTER---PEATDIIEN 326 >3LMG-A nrPDB Length = 344 Score = 146 bits (369), Expect = 1e-35, Method: Composition-based stats. Identities = 47/288 (16%), Positives = 114/288 (39%), Gaps = 30/288 (10%) Query: 16 NTHRPREYWDYESHVVE-WGNQDDYQLVRKLGRGKYSEVFEAINITNNE----KVVVKIL 70 + P + + + V+ + + + ++ LG G + V + + I E V +K++ Sbjct: 9 ESIEPLDPSEKANKVLARIFKETELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVI 68 Query: 71 KPVKKKKIKREIKILENL---RGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ- 126 + ++ + + +I+ L + + LV +++ + Sbjct: 69 EDKSGRQSFQAVTDHMLAIGSLDHAHIVRLLGLC---PGSSLQLVTQYLPLGSLLDHVRQ 125 Query: 127 ---TLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH 183 L + + +I K + Y G++HR++ NV++ ++++ D+G+A+ Sbjct: 126 HRGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKSPS-QVQVADFGVADLLP 184 Query: 184 PGQE---YNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLAS-MIFRKEPF--FHGHD 237 P + Y+ + E + + Y + D+WS G + M F EP+ + Sbjct: 185 PDDKQLLYSEAKTPIKWMALESI-HFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAE 243 Query: 238 NYDQLVRIAKV----LGTEDLYDYIDKYNI---ELDPRFNDILGRHSR 278 D L + ++ + T D+Y + K + + P F ++ +R Sbjct: 244 VPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKELANEFTR 291 >5WNO-A nrPDB Length = 330 Score = 145 bits (367), Expect = 2e-35, Method: Composition-based stats. Identities = 47/284 (16%), Positives = 104/284 (36%), Gaps = 29/284 (10%) Query: 40 QLVRKLGRGKYSEVFEAIN-----ITNNEKVVVKILKPVKKK--KIKREIKILENLRGGP 92 +L +KLG G + VF I V +K+ + + + ++ E + LR Sbjct: 25 KLDKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTDQSQTDEMLEEATNMFRLRHD- 83 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTD----YDIRFYMYEILKALDYCH 148 N++ + +V + + + + + + Y Y+I + Y Sbjct: 84 NLLKIIGFC--MHDDGLKIVTIYRPLGNLQNFLKLHKENLGAREQVLYCYQIASGMQYLE 141 Query: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFY-HPGQEYNVRVASRY--FKGPELLVD 205 ++HRD+ NV++ + + + D+GL++ H ++ + E+ Sbjct: 142 KQRVVHRDLATRNVLV-KKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIEIFSK 200 Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHG--HDNYDQLVRIAKVLGTE-----DLYDYI 258 + Y ++ D+W+ G +I + + G D+ ++ L DLY + Sbjct: 201 HC-YTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQPPNCSQDLYQEL 259 Query: 259 DKY---NIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALD 299 + + + P F + R + EN + +S L Sbjct: 260 LRCWMADPKSRPGFEILYERFKEFCKVPQLFLENSNKISESDLS 303 >3SOC-A nrPDB Length = 322 Score = 144 bits (364), Expect = 5e-35, Method: Composition-based stats. Identities = 60/315 (19%), Positives = 117/315 (37%), Gaps = 50/315 (15%) Query: 31 VEWGNQDDY------QLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKI 84 V+ G ++ Y QL+ RG++ V++A + NE V VKI K+ + E ++ Sbjct: 12 VDLGTENLYFQSMPLQLLEVKARGRFGCVWKAQLL--NEYVAVKIFPIQDKQSWQNEYEV 69 Query: 85 LENL--RGGPNIITLADIVK--DPVSRTPALVFEHVNNTDFKQLYQT--LTDYDIRFYMY 138 L NI+ K V L+ + ++ ++ Sbjct: 70 YS-LPGMKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAE 128 Query: 139 EILKALDYCHS----------MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ-- 186 + + L Y H I HRD+K NV++ + + + D+GLA + G+ Sbjct: 129 TMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKN-NLTACIADFGLALKFEAGKSA 187 Query: 187 -EYNVRVASRYFKGPELLVDYQMYDY----SLDMWSLGCMLASMIFRKEPFFHGHDNYDQ 241 + + +V +R + PE+L + +DM+++G +L + R Sbjct: 188 GDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCT----------- 236 Query: 242 LVRIAKVLGTEDLYDYIDKYNIELDPRFNDILG-RHSRKRWERFVHSENQHLVSPEALDF 300 G D Y + I P D+ +K+ +H + Sbjct: 237 -----AADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCET 291 Query: 301 LDKLLRYDHQSRLTA 315 +++ +D ++RL+A Sbjct: 292 IEECWDHDAEARLSA 306 >4TN6-A nrPDB Length = 318 Score = 142 bits (357), Expect = 4e-34, Method: Composition-based stats. Identities = 49/256 (19%), Positives = 99/256 (38%), Gaps = 19/256 (7%) Query: 31 VEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKI-LKPVKKKKIKREIKILENLR 89 +E + Y+L RK+G G + +++ +I E+V +K+ K ++ E KI + ++ Sbjct: 1 MELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQ 60 Query: 90 GGPNIITLADIVKDPVSRTPALVFEHVN---NTDFKQLYQTLTDYDIRFYMYEILKALDY 146 GG I T+ +V E + F + + + +++ ++Y Sbjct: 61 GGVGIPTIRWC--GAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEY 118 Query: 147 CHSMGIMHRDVKPHNVM--IDHEHRKLRLIDWGLAEFYHPGQEY--------NVRVASRY 196 HS +HRDVKP N + + + + +ID+GLA+ Y + + + Sbjct: 119 IHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTAR 178 Query: 197 FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPF--FHGHDNYDQLVRIAKVLGTEDL 254 + + + D+ SLG +L P+ + RI++ + + Sbjct: 179 YASINTHLGIEQ-SRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPI 237 Query: 255 YDYIDKYNIELDPRFN 270 Y E N Sbjct: 238 EVLCKGYPSEFATYLN 253 >3SV0-A nrPDB Length = 483 Score = 140 bits (354), Expect = 7e-34, Method: Composition-based stats. Identities = 52/282 (18%), Positives = 104/282 (36%), Gaps = 30/282 (10%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK-PVKKKKIKREIKILENLRGGPNI- 94 + ++L RK+G G + E++ NI NE+V +K+ K ++ E KI L+GG I Sbjct: 7 NKFRLGRKIGSGSFGEIYLGTNIQTNEEVAIKLENVKTKHPQLLYESKIYRILQGGTGIP 66 Query: 95 -ITLADIVKDPVSRTPALVFEHVN---NTDFKQLYQTLTDYDIRFYMYEILKALDYCHSM 150 + + LV + + F + L+ + +++ +++ HS Sbjct: 67 NVRWFGV----EGDYNVLVMDLLGPSLEDLFNFCSRKLSLKTVLMLADQMINRVEFVHSK 122 Query: 151 GIMHRDVKPHNVM--IDHEHRKLRLIDWGLAEFYHPGQEY--------NVRVASRYFKGP 200 +HRD+KP N + + ++ +ID+GLA+ Y + + + Sbjct: 123 SFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDTSTHQHIPYRENKNLTGTARYASV 182 Query: 201 ELLVDYQMYDYSLDMWSLGCMLASMIFRKEPF--FHGHDNYDQLVRIAKVLGTEDLYDYI 258 + + D+ SLG +L + P+ + +I++ + Sbjct: 183 NTHLGIEQ-SRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKYEKISEKKVATSIEALC 241 Query: 259 DKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDF 300 Y E F+ R RF + + D Sbjct: 242 RGYPTEFASYFH-------YCRSLRFDDKPDYSYLKRLFRDL 276 >2CHL-A nrPDB Length = 351 Score = 140 bits (354), Expect = 8e-34, Method: Composition-based stats. Identities = 55/283 (19%), Positives = 110/283 (38%), Gaps = 27/283 (9%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK--KIKREIKILENLRGGPNII 95 ++++ +K+G G + E+ N+ NE V +K L+P+K + ++ E + + L G I Sbjct: 31 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIK-LEPMKSRAPQLHLEYRFYKQLGSGDGIP 89 Query: 96 TLADIVKDPVSRTPALVFEHVN---NTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGI 152 + P + A+V E + F +T + + +++ ++Y HS + Sbjct: 90 QVYYF--GPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNL 147 Query: 153 MHRDVKPHNVMIDHEHRK----LRLIDWGLAEFY--------HPGQEYNVRVASRYFKGP 200 ++RDVKP N +I K + +ID+ LA+ Y P +E+ + + Sbjct: 148 IYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSI 207 Query: 201 ELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDK 260 + + D+ +LG M + P+ D L + +G I+ Sbjct: 208 NTHLGKEQ-SRRDDLEALGHMFMYFLRGSLPWQGLK--ADTLKERYQKIGDTKRATPIEV 264 Query: 261 YNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDK 303 L F ++ R F + + D D+ Sbjct: 265 ----LCENFPEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDR 303 >5XD6-A nrPDB Length = 305 Score = 140 bits (352), Expect = 1e-33, Method: Composition-based stats. Identities = 41/225 (18%), Positives = 84/225 (37%), Gaps = 26/225 (11%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK--KKIKREIKILENLRGGPNI 94 D+Y +G G Y VF I + + +K L K+ ++ ++ ++ LR N+ Sbjct: 22 DNYGSKSLIGEGSYGRVFYGILK-SGKAAAIKKLDSSKQPDQEFLAQVSMVSRLRQ-ENV 79 Query: 95 ITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ------------TLTDYDIRFYMYEILK 142 + L D R L +E+ N + L+ + + Sbjct: 80 VALLGYCVDGPLR--VLAYEYAPNGSLHDILHGRKGVKGAQPGPVLSWHQRVKIAVGAAR 137 Query: 143 ALDYCHSM---GIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ---EYNVRVASRY 196 L+Y H ++HRD+K NV++ + ++ D+ L+ + + Sbjct: 138 GLEYLHEKANPHVIHRDIKSSNVLLFDDD-VAKIADFDLSNQAPDMAARLHSTRVLGTFG 196 Query: 197 FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQ 241 + PE + + D++S G +L ++ ++P H Q Sbjct: 197 YHAPEYAMTGTL-STKSDVYSFGVVLLELLTGRKPVDHTLPRGQQ 240 >5AR8-A nrPDB Length = 326 Score = 140 bits (352), Expect = 1e-33, Method: Composition-based stats. Identities = 59/303 (19%), Positives = 118/303 (38%), Gaps = 44/303 (14%) Query: 42 VRKLGRGKYSEVFEAINITNNEKVVVKILK------PVKKKKIKREIKILENLRGGPNII 95 +R L RG V A + +V VK L ++K + RE +IL R I+ Sbjct: 37 LRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKAR-FSYIL 95 Query: 96 TLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTD-----YDIRF-YMYEILKALDYCHS 149 + I +P +V E++ N +L T+ + +RF ++EI ++Y H+ Sbjct: 96 PILGICNEP--EFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHN 153 Query: 150 MG--IMHRDVKPHNVMIDHEHRKLRLIDWGLAEF------YHPGQEYNVRVASRYFKGPE 201 M ++H D+K N+++D+E +++ D+GL+++ + + + PE Sbjct: 154 MTPPLLHHDLKTQNILLDNE-FHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPE 212 Query: 202 LLVDYQMY--DYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYID 259 Q D++S + ++ RK+PF + + +++ I+ Sbjct: 213 NYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQ-----GHRPVIN 267 Query: 260 KYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSR----LTA 315 + ++ D + W + FL L+ + R +T Sbjct: 268 EESLPYDIPHRARMISLIESGWAQNPDERPS---------FLKCLIELEPVLRTFEEITF 318 Query: 316 REA 318 EA Sbjct: 319 LEA 321 >2Y4I-B nrPDB Length = 319 Score = 139 bits (350), Expect = 2e-33, Method: Composition-based stats. Identities = 56/329 (17%), Positives = 115/329 (34%), Gaps = 59/329 (17%) Query: 20 PREYWDYESHVVEWGNQ-DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL-----KPV 73 PR+ + EW + ++ +G+G++ +V+ + +V ++++ Sbjct: 15 PRKASQTSIFLQEWDIPFEQLEIGELIGKGRFGQVYHGRW---HGEVAIRLIDIERDNED 71 Query: 74 KKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ----TLT 129 + K KRE+ R N++ P A++ + + L Sbjct: 72 QLKAFKREVMAYRQTRH-ENVVLFMGACMSPP--HLAIITSLCKGRTLYSVVRDAKIVLD 128 Query: 130 DYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGL---AEFYHPGQ 186 R EI+K + Y H+ GI+H+D+K NV +++ K+ + D+GL + G+ Sbjct: 129 VNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVF--YDNGKVVITDFGLFSISGVLQAGR 186 Query: 187 EYNVRVASRYF---KGPELLVDYQ--------MYDYSLDMWSLGCMLASMIFRKEPFFHG 235 + + PE++ + D+++LG + + R+ PF Sbjct: 187 REDKLRIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPF--- 243 Query: 236 HDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSP 295 T+ I + + P + I F + Q P Sbjct: 244 --------------KTQPAEAIIWQMGTGMKPNLSQIGMGKEISDILLFCWAFEQEER-P 288 Query: 296 EALDFLDKLLRYDHQ--SRLTAREAMEHP 322 +D +L + RL+ HP Sbjct: 289 TFTKLMD-MLEKLPKRNRRLS------HP 310 >2QKW-B nrPDB Length = 321 Score = 138 bits (349), Expect = 3e-33, Method: Composition-based stats. Identities = 47/287 (16%), Positives = 109/287 (37%), Gaps = 38/287 (13%) Query: 45 LGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLR--GGPNIITLADIVK 102 +G G + +V++ + + + KV +K P + I+ +E L P++++L Sbjct: 47 IGHGVFGKVYKGV-LRDGAKVALKRRTPESSQGIEEFETEIETLSFCRHPHLVSLIGFCD 105 Query: 103 DPVSRTPALVFEHVNNTDFKQLY-------QTLTDYDIRFYMYEILKALDYCHSMGIMHR 155 + L+++++ N + K+ +++ + L Y H+ I+HR Sbjct: 106 E--RNEMILIYKYMENGNLKRHLYGSDLPTMSMSWEQRLEICIGAARGLHYLHTRAIIHR 163 Query: 156 DVKPHNVMIDHEHRKLRLIDWGLAE---FYHPGQEYNVRVASRYFKGPELLVDYQMYDYS 212 DVK N+++D E+ ++ D+G+++ V + + PE + ++ Sbjct: 164 DVKSINILLD-ENFVPKITDFGISKKGTELDQTHLSTVVKGTLGYIDPEYFIKGRL-TEK 221 Query: 213 LDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDI 272 D++S G +L ++ R A V + ++ +E N Sbjct: 222 SDVYSFGVVLFEVLC---------------ARSAIVQSLPREMVNLAEWAVESHN--NGQ 264 Query: 273 LGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAM 319 L + + E+ A+ K L + R + + + Sbjct: 265 LEQIVDPNLADKIRPESLRKFGDTAV----KCLALSSEDRPSMGDVL 307 >5E8V-A nrPDB Length = 316 Score = 138 bits (349), Expect = 3e-33, Method: Composition-based stats. Identities = 55/305 (18%), Positives = 116/305 (38%), Gaps = 45/305 (14%) Query: 40 QLVRKLGRGKYSEVFEAINITNN----EKVVVKILKPVKKKKIKREIKILENLR-GGPNI 94 +L +G+G+++EV++A N E V VKI + K E I ++ NI Sbjct: 12 ELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENI 71 Query: 95 ITLADIVK--DPVSRTPALVFEHVNNTDFKQLY--QTLTDYDIRFYMYEILKALDYCHS- 149 + + + + L+ + ++ ++ D+R + + + + HS Sbjct: 72 LQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSD 131 Query: 150 --------MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHP-----GQEYNVRVASRY 196 M I+HRD+K N+++ ++ L D+GL+ P + +V + Sbjct: 132 HTPCGRPKMPIVHRDLKSSNILVKND-LTCCLCDFGLSLRLDPTLSVDDLANSGQVGTAR 190 Query: 197 FKGPELLVDYQMYD-----YSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGT 251 + PE+L + D++S+ +L M R + +V Sbjct: 191 YMAPEVLASAMNLENVESFKQTDVYSMALVLWEMTSRC-------------NAVGEVKDY 237 Query: 252 EDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQS 311 E + + + + +++L R F + + E L + +D ++ Sbjct: 238 EPPFGSKVREHPCVASMADNVLADAGRPEIPSFWLNHQGIQMVCET---LTECWDHDPEA 294 Query: 312 RLTAR 316 RLTA+ Sbjct: 295 RLTAQ 299 >4BTK-A nrPDB Length = 337 Score = 138 bits (347), Expect = 4e-33, Method: Composition-based stats. Identities = 50/225 (22%), Positives = 104/225 (46%), Gaps = 15/225 (6%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKR-EIKILENLRGGPNI 94 +D +++++K+G G + E++EA+++ E V +K+ + K++ + E+ +L+ L+G ++ Sbjct: 55 KDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDHV 114 Query: 95 ITLADIVKDPVSRTPALVFEHVNNTDFK--QLYQTLTDYDIRFYMYEILKALDYCHSMGI 152 ++ + + N D + Q T T +IL++++ HS+G Sbjct: 115 CRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHSVGF 174 Query: 153 MHRDVKPHNVMID---HEHRKLRLIDWGLAEFY-------HPGQEYNVRVASRYFKGPEL 202 +HRD+KP N + +RK ++D+GLA Y P + + + Sbjct: 175 LHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRYASVNA 234 Query: 203 LVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAK 247 + +M D+WSL ML + P+ D +Q+ I + Sbjct: 235 HKNREM-GRHDDLWSLFYMLVEFAVGQLPWRKIKDK-EQVGMIKE 277 >5FQD-C nrPDB Length = 341 Score = 137 bits (346), Expect = 6e-33, Method: Composition-based stats. Identities = 50/201 (24%), Positives = 89/201 (44%), Gaps = 18/201 (8%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK-PVKKKKIKREIKILENLRGGPNIIT 96 Y+LVRK+G G + +++ AINITN E+V VK+ + ++ E K+ + L+GG I Sbjct: 20 KYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIPH 79 Query: 97 LADIVKDPVSRTPALVFEHVN---NTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIM 153 + ++ LV + + F + T + +++ ++Y H+ + Sbjct: 80 IRWYGQEK--DYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFI 137 Query: 154 HRDVKPHNVM--IDHEHRKLRLIDWGLAEFYHPGQEY--------NVRVASRYFKGPELL 203 HRD+KP N + I KL LID+GLA+ Y + + + Sbjct: 138 HRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAH 197 Query: 204 VDYQMYDYSLDMWSLG-CMLA 223 + + DM SLG ++ Sbjct: 198 LGIEQ-SRRDDMESLGYVLMY 217 >4NFN-A nrPDB Length = 309 Score = 137 bits (345), Expect = 8e-33, Method: Composition-based stats. Identities = 50/225 (22%), Positives = 104/225 (46%), Gaps = 15/225 (6%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKR-EIKILENLRGGPNI 94 +D +++++K+G G + E++EA+++ E V +K+ + K++ + E+ +L+ L+G ++ Sbjct: 20 KDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDHV 79 Query: 95 ITLADIVKDPVSRTPALVFEHVNNTDFK--QLYQTLTDYDIRFYMYEILKALDYCHSMGI 152 ++ + + N D + Q T T +IL++++ HS+G Sbjct: 80 CRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHSVGF 139 Query: 153 MHRDVKPHNVMID---HEHRKLRLIDWGLAEFY-------HPGQEYNVRVASRYFKGPEL 202 +HRD+KP N + +RK ++D+GLA Y P + + + Sbjct: 140 LHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRYASVNA 199 Query: 203 LVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAK 247 + +M D+WSL ML + P+ D +Q+ I + Sbjct: 200 HKNREM-GRHDDLWSLFYMLVEFAVGQLPWRKIKDK-EQVGMIKE 242 >2C47-A nrPDB Length = 313 Score = 136 bits (342), Expect = 2e-32, Method: Composition-based stats. Identities = 51/283 (18%), Positives = 106/283 (37%), Gaps = 26/283 (9%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK--KIKREIKILENLRGGPNII 95 ++++ +K+G G + E+ N+ NE V +K L+P+K + ++ E + + L + Sbjct: 5 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIK-LEPIKSRAPQLHLEYRFYKQLSATEGVP 63 Query: 96 TLADIVKDPVSRTPALVFEHVN---NTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGI 152 + P + A+V E + F +T T + +++ ++Y H+ + Sbjct: 64 QVYYF--GPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYVHTKSL 121 Query: 153 MHRDVKPHNVMIDHEH----RKLRLIDWGLAEFY--------HPGQEYNVRVASRYFKGP 200 ++RDVKP N ++ + +ID+GLA+ Y P +E+ + + Sbjct: 122 IYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSI 181 Query: 201 ELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDK 260 + + D+ +LG M + P+ D L + +G I+ Sbjct: 182 NTHLGKEQ-SRRDDLEALGHMFMYFLRGSLPWQGLK--ADTLKERYQKIGDTKRATPIEV 238 Query: 261 YNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDK 303 L R F + + D D+ Sbjct: 239 LCENFPEEMATYLRYVRRLD---FFEKPDYDYLRKLFTDLFDR 278 >2QLU-A nrPDB Length = 314 Score = 135 bits (341), Expect = 2e-32, Method: Composition-based stats. Identities = 57/306 (18%), Positives = 114/306 (37%), Gaps = 47/306 (15%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENL-RGGPNI 94 + QL+ RG++ V++A + N+ V VKI K+ + E +I N+ Sbjct: 14 RGSLQLLEIKARGRFGCVWKAQLM--NDFVAVKIFPLQDKQSWQSEREIFSTPGMKHENL 71 Query: 95 ITLADIVK--DPVSRTPALVFEHVNNTDFKQLYQT--LTDYDIRFYMYEILKALDYCHS- 149 + K + L+ + + +T ++ + + L Y H Sbjct: 72 LQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHED 131 Query: 150 ----------MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ---EYNVRVASRY 196 I HRD K NV++ + + L D+GLA + PG+ + + +V +R Sbjct: 132 VPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAV-LADFGLAVRFEPGKPPGDTHGQVGTRR 190 Query: 197 FKGPELLVDYQMYDY----SLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTE 252 + PE+L + +DM+++G +L ++ R + G Sbjct: 191 YMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCK----------------AADGPV 234 Query: 253 DLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDF---LDKLLRYDH 309 D Y + I P ++ K+ ++ L P +++ +D Sbjct: 235 DEYMLPFEEEIGQHPSLEELQEVVVHKK--MRPTIKDHWLKHPGLAQLCVTIEECWDHDA 292 Query: 310 QSRLTA 315 ++RL+A Sbjct: 293 EARLSA 298 >5X18-A nrPDB Length = 295 Score = 135 bits (340), Expect = 3e-32, Method: Composition-based stats. Identities = 46/263 (17%), Positives = 106/263 (40%), Gaps = 18/263 (6%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL-KPVKKKKIKREIKILENLRGGPNIIT 96 Y++ +K+G G + +FE N+ N V +K + + +++ E K + L G PNI Sbjct: 8 HYKIGKKIGEGSFGVLFEGTNMINGVPVAIKFEPRKTEAPQLRDEYKTYKILNGTPNIPY 67 Query: 97 LADIVKDPVSRTPALVFEHVNNTD-FKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHR 155 ++ + + + D F + + + +++ ++ H+ +++R Sbjct: 68 AYYFGQEGLHNILVIDLLGPSLEDLFDWCGRKFSVKTVVQVAVQMITLIEDLHAHDLIYR 127 Query: 156 DVKPHNVMIDHEH----RKLRLIDWGLAEFYH--------PGQEYNVRVASRYFKGPELL 203 D+KP N +I + LID+G+A+ Y P +E + + Sbjct: 128 DIKPDNFLIGRPGQPDANNIHLIDFGMAKQYRDPKTKQHIPYREKKSLSGTARYMSINTH 187 Query: 204 VDYQMYDYSLDMWSLGCMLASMIFRKEPF--FHGHDNYDQLVRIAKVLGTEDLYDYIDKY 261 + + DM +LG + + P+ +N + +I + + ++YD Sbjct: 188 LGREQ-SRRDDMEALGHVFFYFLRGHLPWQGLKAPNNKQKYEKIGEKKRSTNVYDLAQGL 246 Query: 262 NIELDPRFNDILGRHSRKRWERF 284 ++ R+ +I+ S + + Sbjct: 247 PVQFG-RYLEIVRSLSFEECPDY 268 >5VC6-A nrPDB Length = 289 Score = 134 bits (338), Expect = 5e-32, Method: Composition-based stats. Identities = 46/314 (14%), Positives = 100/314 (31%), Gaps = 75/314 (23%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKP-----VKKKKIKREIKILENLRGGP 92 ++ + K+G G++ VF+ + + +K K V ++ RE+ L Sbjct: 12 EFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHS 71 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNTDF-------KQLYQTLTDYDIRFYMYEILKALD 145 +++ + + E+ N ++ + +++ + ++ + L Sbjct: 72 HVVRYFSAWAE--DDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLR 129 Query: 146 YCHSMGIMHRDVKPHNVMIDHEHRK------------------LRLIDWGLAEFYHPGQE 187 Y HSM ++H D+KP N+ I ++ D G Q Sbjct: 130 YIHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQ- 188 Query: 188 YNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAK 247 V F E+L + + D+++L + EP D + ++ + Sbjct: 189 --VEEGDSRFLANEVLQENYTHLPKADIFALALTV-VCAAGAEPLPRNGDQWHEIRQGR- 244 Query: 248 VLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRY 307 PR +L S E + L ++ Sbjct: 245 ------------------LPRIPQVL--------------------SQEFTELLKVMIHP 266 Query: 308 DHQSRLTAREAMEH 321 D + R +A ++H Sbjct: 267 DPERRPSAMALVKH 280 >5J0A-A nrPDB Length = 300 Score = 134 bits (337), Expect = 7e-32, Method: Composition-based stats. Identities = 52/308 (16%), Positives = 101/308 (32%), Gaps = 50/308 (16%) Query: 41 LVRKLGRGKYSE-VFEAINITNNEK---VVVKILKP--------VKKKKIKREIKILENL 88 ++KLG G V+ VK + P V +K++ E KIL++L Sbjct: 13 FMQKLGFGT-GVNVYLMKRSPRGLSHSPWAVKKINPICNDHYRSVYQKRLMDEAKILKSL 71 Query: 89 RGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ--------TLTDYDIRFYMYEI 140 PNI+ + + L E+ L + I + Sbjct: 72 -HHPNIVGYR-AFTEANDGSLCLAMEYGGEKSLNDLIEERYKASQDPFPAAIILKVALNM 129 Query: 141 LKALDYCHS-MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNV----RVASR 195 + L Y H ++H D+K NV+I + +++ D G++ E + + Sbjct: 130 ARGLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMEVTDPEACYIGTE 189 Query: 196 YFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLY 255 +K E + + + D+++ G L M+ P +L Sbjct: 190 PWKPKEAVEENGVITDKADIFAFGLTLWEMMTLSIP-------------------HINLS 230 Query: 256 DYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTA 315 + D + D D ++ ++ E + ++ D + R +A Sbjct: 231 NDDDDEDKTFDESDFDDEAYYAALGTRPPINMEELDESYQKVIELFSVCTNEDPKDRPSA 290 Query: 316 R---EAME 320 EA+E Sbjct: 291 AHIVEALE 298 >2CMW-A nrPDB Length = 310 Score = 133 bits (336), Expect = 9e-32, Method: Composition-based stats. Identities = 55/282 (19%), Positives = 106/282 (37%), Gaps = 27/282 (9%) Query: 40 QLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK--KIKREIKILENLRG-GPNIIT 96 ++ +K+G G + E+ N+ NE V +K L+P+K + ++ E + + L G + Sbjct: 3 RVGKKIGCGNFGELRLGKNLYTNEYVAIK-LEPIKSRAPQLHLEYRFYKQLGSAGEGLPQ 61 Query: 97 LADIVKDPVSRTPALVFEHVN---NTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIM 153 + P + A+V E + F +T T + ++L ++Y HS ++ Sbjct: 62 VYYF--GPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYVHSKNLI 119 Query: 154 HRDVKPHNVMIDHEH----RKLRLIDWGLAEFY--------HPGQEYNVRVASRYFKGPE 201 +RDVKP N +I + + +ID+GLA+ Y P +E+ + + Sbjct: 120 YRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSIN 179 Query: 202 LLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKY 261 + + D+ +LG M + P+ D L + +G I+ Sbjct: 180 THLGKEQ-SRRDDLEALGHMFMYFLRGSLPWQGLK--ADTLKERYQKIGDTKRNTPIEAL 236 Query: 262 NIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDK 303 L R F + + D +K Sbjct: 237 CENFPEEMATYLRYVRRLD---FFEKPDYEYLRTLFTDLFEK 275 >4NT4-A nrPDB Length = 312 Score = 133 bits (335), Expect = 1e-31, Method: Composition-based stats. Identities = 56/287 (19%), Positives = 111/287 (38%), Gaps = 28/287 (9%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK--KIKREIKILENLRGG---- 91 ++++ +K+G G + E+ N+ NNE V +K ++P+K K ++ E + + L Sbjct: 13 NFRVGKKIGCGNFGELRLGKNLYNNEHVAIK-MEPMKSKAPQLHLEYRFYKLLGSHADNA 71 Query: 92 PNIITLADIVKDPVSRTPALVFEHVNNTD---FKQLYQTLTDYDIRFYMYEILKALDYCH 148 P+ I + R A+V E + + F + + + ++L ++Y H Sbjct: 72 PDGIPRIYHLGTCGGRYNAMVLELLGLSLEDLFNICARKFSLKTVLMIAKQLLHRIEYVH 131 Query: 149 SMGIMHRDVKPHNVMI----DHEHRKLRLIDWGLAEFY--------HPGQEYNVRVASRY 196 S +++RDVKP N +I + + +ID+GLA+ Y P +E+ + Sbjct: 132 SRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRHIPYREHKSLTGTAR 191 Query: 197 FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYD 256 + + + D+ +LG M + P+ D L + +G Sbjct: 192 YMSINTHMGREQ-SRRDDLEALGHMFMYFLRGSLPWQGLK--ADTLKERYQKIGDTKRAT 248 Query: 257 YIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDK 303 I+ F L R F + + + D D+ Sbjct: 249 PIEVLCDGHPEEFATYLRYVRRLD---FFETPDYDFLRRLFQDLFDR 292 >5VDK-A nrPDB Length = 297 Score = 131 bits (330), Expect = 5e-31, Method: Composition-based stats. Identities = 47/326 (14%), Positives = 102/326 (31%), Gaps = 79/326 (24%) Query: 25 DYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKI-LKP----VKKKKIK 79 ++ S + + ++ V K+G G++ V++ I + +K +K + Sbjct: 3 EFGSTNMASRYEKEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSAL 62 Query: 80 REIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY-------QTLTDYD 132 E+ L P+++ + + E+ N + + Sbjct: 63 HEVYAHAVLGHHPHVVRYYSSWAE--DDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPK 120 Query: 133 IRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHE----------------------HRK 170 ++ + +I L+Y H+ ++H D+KP N+ I H+ + Sbjct: 121 LKDILLQISLGLNYIHNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVM 180 Query: 171 LRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKE 230 ++ D G A + + V F E+L + + D+++LG Sbjct: 181 YKIGDLGHATSIN---KPKVEEGDSRFLANEILQEDYRHLPKADIFALGLT--------- 228 Query: 231 PFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQ 290 IA G E L ++ F D+ Sbjct: 229 --------------IAVAAGAESLPTNGAAWHHIRKGNFPDVPQE--------------- 259 Query: 291 HLVSPEALDFLDKLLRYDHQSRLTAR 316 +S L +++ D + R +A Sbjct: 260 --LSESFSSLLKNMIQPDAEQRPSAA 283 >2PZI-A nrPDB Length = 681 Score = 131 bits (329), Expect = 6e-31, Method: Composition-based stats. Identities = 59/246 (23%), Positives = 108/246 (43%), Gaps = 31/246 (12%) Query: 38 DYQLVRKLGRGKYSEVFEAINIT-NNEKVVVKIL----------KPVKKKKIKREIKILE 86 Y++ + G ++ A++ N VV+K L + +++ E+ Sbjct: 81 QYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAERQFLAEVV--- 137 Query: 87 NLRGGPNIITLADIVKDPVSRTP---ALVFEHVNNTDFKQ-LYQTLTDYDIRFYMYEILK 142 P+I+ + + V+ +V E+V K+ Q L + Y+ EIL Sbjct: 138 ----HPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSLKRSKGQKLPVAEAIAYLLEILP 193 Query: 143 ALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPEL 202 AL Y HS+G+++ D+KP N+M+ E +L+LID G + + + F+ PE+ Sbjct: 194 ALSYLHSIGLVYNDLKPENIMLTEE--QLKLIDLGAVSRINS---FGYLYGTPGFQAPEI 248 Query: 203 LVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYN 262 + + D++++G LA++ P +G D L VL T D Y + + Sbjct: 249 VRTGP--TVATDIYTVGRTLAAL-TLDLPTRNGR-YVDGLPEDDPVLKTYDSYGRLLRRA 304 Query: 263 IELDPR 268 I+ DPR Sbjct: 305 IDPDPR 310 >4Y12-A nrPDB Length = 375 Score = 130 bits (328), Expect = 7e-31, Method: Composition-based stats. Identities = 59/246 (23%), Positives = 108/246 (43%), Gaps = 31/246 (12%) Query: 38 DYQLVRKLGRGKYSEVFEAINIT-NNEKVVVKIL----------KPVKKKKIKREIKILE 86 Y++ + G ++ A++ N VV+K L + +++ E+ Sbjct: 120 QYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAERQFLAEVV--- 176 Query: 87 NLRGGPNIITLADIVKDPVSRTP---ALVFEHVNNTDFKQ-LYQTLTDYDIRFYMYEILK 142 P+I+ + + V+ +V E+V K+ Q L + Y+ EIL Sbjct: 177 ----HPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSLKRSKGQKLPVAEAIAYLLEILP 232 Query: 143 ALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPEL 202 AL Y HS+G+++ D+KP N+M+ E +L+LID G + + + F+ PE+ Sbjct: 233 ALSYLHSIGLVYNDLKPENIMLTEE--QLKLIDLGAVSRINS---FGYLYGTPGFQAPEI 287 Query: 203 LVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYN 262 + + D++++G LA++ P +G D L VL T D Y + + Sbjct: 288 VRTGP--TVATDIYTVGRTLAAL-TLDLPTRNGR-YVDGLPEDDPVLKTYDSYGRLLRRA 343 Query: 263 IELDPR 268 I+ DPR Sbjct: 344 IDPDPR 349 >3HNG-A nrPDB Length = 360 Score = 129 bits (324), Expect = 3e-30, Method: Composition-based stats. Identities = 32/166 (19%), Positives = 77/166 (46%), Gaps = 16/166 (9%) Query: 124 LYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH 183 + +T D+ Y +++ + +++ S +HRD+ N+++ E+ +++ D+GLA + Sbjct: 192 YKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILL-SENNVVKICDFGLARDIY 250 Query: 184 PGQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIF-RKEPFFHGHDNY 239 +Y + +R + PE + D ++Y D+WS G +L + P+ + Sbjct: 251 KNPDYVRKGDTRLPLKWMAPESIFD-KIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDE 309 Query: 240 DQLVRIAKVL-------GTEDLYDYIDKY---NIELDPRFNDILGR 275 D R+ + + T ++Y + + + PRF +++ + Sbjct: 310 DFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEK 355 Score = 82.0 bits (201), Expect = 4e-16, Method: Composition-based stats. Identities = 24/115 (20%), Positives = 47/115 (40%), Gaps = 11/115 (9%) Query: 22 EYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEA-----INITNNEKVVVKILKP---- 72 E Y++ E+ ++ +L + LGRG + +V +A V VK+LK Sbjct: 13 ERLPYDASKWEFA-RERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATA 71 Query: 73 VKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT 127 + K + E+KIL ++ N++ L +V E+ + ++ Sbjct: 72 SEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIV-EYCKYGNLSNYLKS 125 >4RT7-A nrPDB Length = 415 Score = 128 bits (322), Expect = 4e-30, Method: Composition-based stats. Identities = 35/159 (22%), Positives = 68/159 (42%), Gaps = 11/159 (6%) Query: 80 REIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYE 139 RE++I I L + + +E+ + ++ LT D+ + Y+ Sbjct: 198 REVQIH---PDSDQISGLHG---NSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQ 251 Query: 140 ILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY--- 196 + K +++ +HRD+ NV++ H + +++ D+GLA Y VR +R Sbjct: 252 VAKGMEFLEFKSCVHRDLAARNVLVTH-GKVVKICDFGLARDIMSDSNYVVRGNARLPVK 310 Query: 197 FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHG 235 + PE L + +Y D+WS G +L + + G Sbjct: 311 WMAPESLFE-GIYTIKSDVWSYGILLWEIFSLGVNPYPG 348 Score = 96.2 bits (238), Expect = 2e-20, Method: Composition-based stats. Identities = 25/135 (18%), Positives = 52/135 (38%), Gaps = 19/135 (14%) Query: 11 VYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINI---TNNE--KV 65 Y D + W++ +++ + + LG G + +V A +V Sbjct: 47 FYVDFREYEYDLKWEFP--------RENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQV 98 Query: 66 VVKILKPV----KKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDF 121 VK+LK +++ + E+K++ L NI+ L +S L+FE+ D Sbjct: 99 AVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACT--LSGPIYLIFEYCCYGDL 156 Query: 122 KQLYQTLTDYDIRFY 136 ++ + R + Sbjct: 157 LNYLRSKREKFHRTW 171 >3VHK-A nrPDB Length = 368 Score = 126 bits (317), Expect = 1e-29, Method: Composition-based stats. Identities = 36/197 (18%), Positives = 74/197 (37%), Gaps = 40/197 (20%) Query: 128 LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE 187 LT + Y +++ K +++ S +HRD+ N+++ ++ +++ D+GLA + + Sbjct: 197 LTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKN-VVKICDFGLARDIYKDPD 255 Query: 188 YNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVR 244 Y + +R + PE + D ++Y D+WS G +L + + G Sbjct: 256 YVRKGDARLPLKWMAPETIFD-RVYTIQSDVWSFGVLLWEIFSLGASPYPG--------- 305 Query: 245 IAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKL 304 +++D F L +R R + E + Sbjct: 306 ------------------VKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLD--------C 339 Query: 305 LRYDHQSRLTAREAMEH 321 + R T E +EH Sbjct: 340 WHGEPSQRPTFSELVEH 356 Score = 83.1 bits (204), Expect = 2e-16, Method: Composition-based stats. Identities = 29/126 (23%), Positives = 54/126 (42%), Gaps = 14/126 (11%) Query: 14 DVNTHRPREYWD---YESHVVEWGNQDDYQLVRKLGRGKYSEVFEA----INIT-NNEKV 65 D + E+ + Y++ E+ +D +L + LGRG + +V EA I+ T V Sbjct: 4 DPDELPLDEHCERLPYDASKWEF-PRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTV 62 Query: 66 VVKILKP----VKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDF 121 VK+LK + + + E+KIL ++ N++ L P +V E + Sbjct: 63 AVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIV-EFCKFGNL 121 Query: 122 KQLYQT 127 ++ Sbjct: 122 STYLRS 127 >1CSN-A nrPDB Length = 298 Score = 123 bits (310), Expect = 8e-29, Method: Composition-based stats. Identities = 41/244 (16%), Positives = 96/244 (39%), Gaps = 17/244 (6%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL-KPVKKKKIKREIKILENLRGGPNIIT 96 Y++ R++G G + +FE N+ NN++V +K + +++ E + + L G I Sbjct: 11 HYKVGRRIGEGSFGVIFEGTNLLNNQQVAIKFEPRRSDAPQLRDEYRTYKLLAGCTGIPN 70 Query: 97 LADIVKDPVSRTPALVFEHVNNTDFKQLY-QTLTDYDIRFYMYEILKALDYCHSMGIMHR 155 + ++ + + + D L + + + ++L + H +++R Sbjct: 71 VYYFGQEGLHNVLVIDLLGPSLEDLLDLCGRKFSVKTVAMAAKQMLARVQSIHEKSLVYR 130 Query: 156 DVKPHNVMIDHEHRK----LRLIDWGLAEFYH--------PGQEYNVRVASRYFKGPELL 203 D+KP N +I + K + ++D+G+ +FY P +E + + Sbjct: 131 DIKPDNFLIGRPNSKNANMIYVVDFGMVKFYRDPVTKQHIPYREKKNLSGTARYMSINTH 190 Query: 204 VDYQMYDYSLDMWSLGCMLASMIFRKEPF--FHGHDNYDQLVRIAKVLGTEDLYDYIDKY 261 + + D+ +LG + + P+ N + RI + + L + + Sbjct: 191 LGREQ-SRRDDLEALGHVFMYFLRGSLPWQGLKAATNKQKYERIGEKKQSTPLRELCAGF 249 Query: 262 NIEL 265 E Sbjct: 250 PEEF 253 >5M07-A nrPDB Length = 276 Score = 122 bits (305), Expect = 3e-28, Method: Composition-based stats. Identities = 45/217 (20%), Positives = 84/217 (38%), Gaps = 31/217 (14%) Query: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK------KKKIKREIKILENLRGGP 92 Y +VR LG EV+ + +K+L P +++ +RE ++ L P Sbjct: 32 YTVVRMLGASAMGEVYLVQHPGFPGWQALKVLSPAMAADDEFRRRFQRETEVAARLFH-P 90 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ-----TLTDYDIRFYMYEILKALDYC 147 +I+ + D + + ++V+ D Q L ++ + + ALDY Sbjct: 91 HILEVHD--RGEFDGQLWIAMDYVDGIDATQHMADRFPAVLPVGEVLAIVTAVAGALDYA 148 Query: 148 HSMGIMHRDVKPHNVMIDHE---HRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLV 204 H G++HRDV P NV++ + +++ L D+G+A + PEL Sbjct: 149 HQRGLLHRDVNPANVVLTSQSAGDQRILLADFGIASQ-------------PSYPAPELSA 195 Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQ 241 + + D ++L + P H Q Sbjct: 196 GADVDGRA-DQYALALTAIHLFAGAPPVDRSHTGPLQ 231 >4XHH-A nrPDB Length = 403 Score = 120 bits (302), Expect = 8e-28, Method: Composition-based stats. Identities = 44/283 (15%), Positives = 102/283 (36%), Gaps = 26/283 (9%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK-PVKKKKIKREIKILENLRGGPNIIT 96 +++ RK+G G + +++ N+ + E+V +++ + ++ E ++ + L GG I Sbjct: 8 KFRIGRKIGSGSFGDIYHGTNLISGEEVAIRLESIRSRHPQLDYESRVYKYLSGGVGIPF 67 Query: 97 LADIVKDPVSRTPALVFEHVN---NTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIM 153 + ++ A+V + + F ++ + + +++ + Y H + Sbjct: 68 IRWFGRE--GEYNAMVIDLLGPSLEDLFNYCHRKFSFKTVIMLALQMICRVQYIHGRSFI 125 Query: 154 HRDVKPHNVM--IDHEHRKLRLIDWGLAEFYHPGQEY--------NVRVASRYFKGPELL 203 HRD+KP N + + + +ID+GL++ Y + + + Sbjct: 126 HRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTARYASVNTH 185 Query: 204 VDYQMYDYSLDMWSLGCMLASMIFRKEPF--FHGHDNYDQLVRIAKVLGTEDLYDYIDKY 261 + + D+ SLG ML P+ + RI + + Sbjct: 186 LGIEQ-SRRDDLESLGYMLIYFCKGSLPWQGLKATTKKQKYDRILEKKLCISVETLCAGL 244 Query: 262 NIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKL 304 +E N R +F + ++ D KL Sbjct: 245 PLEFSEYMN-------YCRNLKFDERPDYLYLARLFKDLSIKL 280 >6BFN-A nrPDB Length = 342 Score = 120 bits (300), Expect = 2e-27, Method: Composition-based stats. Identities = 42/212 (19%), Positives = 74/212 (34%), Gaps = 33/212 (15%) Query: 44 KLGRGKYSEVFEAINITNNEKVVVKILKPVK-------KKKIKREIKILENLRGGPNIIT 96 K+G G + V+ A+ VK LK K+ E++ L R PNI+ Sbjct: 29 KIGEGGFGCVYRAVMRNT--VYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRH-PNIVD 85 Query: 97 LADIVKDPVSRTPALVFEHVNNTDFKQLYQ-------TLTDYDIRFYMYEILKALDYCH- 148 A + LV+ + N + L+ + +A+ + H Sbjct: 86 FAGYC--AQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQ 143 Query: 149 -SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF----------YHPGQEYNVRVASRYF 197 S ++H D+K NV++D E +L D+GLA F + + Sbjct: 144 DSPSLIHGDIKSSNVLLD-ERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAY 202 Query: 198 KGPELLVDYQMYDYSLDMWSLGCMLASMIFRK 229 PE + D +S G ++ + + Sbjct: 203 L-PEEYIKTGRLAVDTDTFSFGVVVLETLAGQ 233 >4XHL-A nrPDB Length = 394 Score = 117 bits (294), Expect = 7e-27, Method: Composition-based stats. Identities = 34/209 (16%), Positives = 83/209 (39%), Gaps = 17/209 (8%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK-PVKKKKIKREIKILENLRGGPNIIT 96 +++ RK+G G + +++ N+ + E+V +++ + ++ E ++ L GG I Sbjct: 8 KFRIGRKIGSGSFGDIYHGTNLISGEEVAIRLESIRSRHPQLDYESRVYRYLSGGVGIPF 67 Query: 97 LADIVKDPVSRTPALVFEHVN---NTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIM 153 + ++ A+V + + F ++ + + ++ + Y H + Sbjct: 68 IRWFGRE--GEYNAMVIDLLGPSLEDLFNYCHRRFSFKTVIMLALQMFCRIQYIHGRSFI 125 Query: 154 HRDVKPHNVM--IDHEHRKLRLIDWGLAEFYHPGQEY--------NVRVASRYFKGPELL 203 HRD+KP N + + + +ID+GL++ Y + + + Sbjct: 126 HRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTARYASVNTH 185 Query: 204 VDYQMYDYSLDMWSLGCMLASMIFRKEPF 232 + + D+ SLG +L P+ Sbjct: 186 LGIEQ-SRRDDLESLGYVLIYFCKGSLPW 213 >4MWI-A nrPDB Length = 294 Score = 112 bits (280), Expect = 3e-25, Method: Composition-based stats. Identities = 44/276 (15%), Positives = 96/276 (34%), Gaps = 58/276 (21%) Query: 65 VVVKILKPVK-------KKKIKREIKILENLRGGPNIITLADIVKDPVSRTPA--LVFEH 115 V +K+ K ++ ++ +EIK ++ PNI+ + I D P +V E+ Sbjct: 50 VAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFE-SPNILRIFGICIDETVTPPQFSIVMEY 108 Query: 116 VNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCHSMGI--MHRDVKPHNVMIDHEHRK 170 ++L + LT + + L H +H ++ N ++ + + Sbjct: 109 CELGTLRELLDREKDLTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVT-QGYQ 167 Query: 171 LRLIDWGLAEF-----YHPGQEYNVRVASRYFKGPELLVD-YQMYDYSLDMWSLGCMLAS 224 ++L + L + +E RV S + P+ L D + YD +++S G +L Sbjct: 168 VKLAGFELRKTQTSMSLGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWE 227 Query: 225 MIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERF 284 + PF + +I K++ + + + Sbjct: 228 IATGDIPFQGCNSE-----KIRKLVAVKRQQEPLG------------------------- 257 Query: 285 VHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAME 320 E + +D+ +D R + E ++ Sbjct: 258 ------EDCPSELREIIDECRAHDPSVRPSVDEILK 287 >5UV4-A nrPDB Length = 311 Score = 112 bits (279), Expect = 4e-25, Method: Composition-based stats. Identities = 54/280 (19%), Positives = 105/280 (37%), Gaps = 40/280 (14%) Query: 43 RKLGRGKYSEVFEAINITNNEKVVVKILKP---VKKKKIKREIKILENLRGGPNIITLAD 99 +GR + ++A + N + VK LK KK+ REIK L ++R PN++ L Sbjct: 31 EIIGRSCHGTSYKAT-LDNGYMLTVKWLKEGFAKSKKEFSREIKKLGSVRH-PNLVPLRG 88 Query: 100 IVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDI--------RFYMYEILKALDYCHSMG 151 P ++ ++ + T + ++ +I + LDY H+ Sbjct: 89 YYWGPKEHERIMISDYADATSLSTYLSEFDERNLPPLSAGQRLNIAIDIARCLDYLHNER 148 Query: 152 IM-HRDVKPHNVMIDHEHRKLRLIDWGLAEFYHP--GQEYNVRVASRYFKGPELLVDYQM 208 ++ H ++K NV+I + + D+ L P E + + + PE + Sbjct: 149 VIPHGNIKSSNVLIQNSTPSALVTDYSLHRLMTPIGMAEQVLNAGALGYSPPEFSSTSKP 208 Query: 209 Y-DYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDP 267 D+++ G +L ++ K I G DL D++ ++E Sbjct: 209 CPSLKSDVYAFGVILLELLTGKI----------AGEIICMNDGVVDLTDWVRMLDLEER- 257 Query: 268 RFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRY 307 + ++R + +P+ALD +LR Sbjct: 258 ---------VSECYDRHITGVESSEGAPQALD---GMLRI 285 >4BTF-A nrPDB Length = 469 Score = 106 bits (264), Expect = 2e-23, Method: Composition-based stats. Identities = 41/253 (16%), Positives = 93/253 (36%), Gaps = 25/253 (9%) Query: 65 VVVKILKPVKKK-------KIKREIKILENLRGGPNIITLADIVKDPVSRTP--ALVFEH 115 V +K+ + + EIK ++ PNI+ + I D + P ++V E+ Sbjct: 221 VTIKVFNNPQAESVGIVRFTFNDEIKTMKKF-DSPNILRIFGICIDQTVKPPEFSIVMEY 279 Query: 116 VNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLR 172 ++L + LT + + L H +HR++ + ++ +++ Sbjct: 280 CELGTLRELLDREKDLTMSVRSLLVLRAARGLYRLHHSETLHRNISSSSFLV-AGGYQVK 338 Query: 173 LIDWGLAEFYHPGQEYN-----VRVASRYFKGPELLVD-YQMYDYSLDMWSLGCMLASMI 226 L + L++ + R +S + PE L + + +YD +++S G +L + Sbjct: 339 LAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDIKAEIYSFGIVLWEIA 398 Query: 227 FRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVH 286 K PF +I +++ + + + + EL + H + Sbjct: 399 TGKIPFEGCDS-----KKIRELVAEDKKQEPVGQDCPELLREIINECRAHEPSQRPSVDG 453 Query: 287 SENQHLVSPEALD 299 + E+ D Sbjct: 454 ILERLSAVEESTD 466 >4M69-B nrPDB Length = 283 Score = 105 bits (263), Expect = 2e-23, Method: Composition-based stats. Identities = 41/253 (16%), Positives = 93/253 (36%), Gaps = 25/253 (9%) Query: 65 VVVKILKPVKKK-------KIKREIKILENLRGGPNIITLADIVKDPVSRTP--ALVFEH 115 V +K+ + + EIK ++ PNI+ + I D + P ++V E+ Sbjct: 35 VTIKVFNNPQAESVGIVRFTFNDEIKTMKKF-DSPNILRIFGICIDQTVKPPEFSIVMEY 93 Query: 116 VNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLR 172 ++L + LT + + L H +HR++ + ++ +++ Sbjct: 94 CELGTLRELLDREKDLTMSVRSLLVLRAARGLYRLHHSETLHRNISSSSFLV-AGGYQVK 152 Query: 173 LIDWGLAEFYHPGQEYN-----VRVASRYFKGPELLVD-YQMYDYSLDMWSLGCMLASMI 226 L + L++ + R +S + PE L + + +YD +++S G +L + Sbjct: 153 LAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDIKAEIYSFGIVLWEIA 212 Query: 227 FRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVH 286 K PF +I +++ + + + + EL + H + Sbjct: 213 TGKIPFEGCDS-----KKIRELVAEDKKQEPVGQDCPELLREIINECRAHEPSQRPSVDG 267 Query: 287 SENQHLVSPEALD 299 + E+ D Sbjct: 268 ILERLSAVEESTD 280 >4JRN-A nrPDB Length = 372 Score = 104 bits (259), Expect = 7e-23, Method: Composition-based stats. Identities = 51/319 (15%), Positives = 94/319 (29%), Gaps = 90/319 (28%) Query: 44 KLGRGKYSEVFEAINITNNEKVVVKILKPVKKK------KIKREIKILENLRGGP----- 92 LG G ++ V+EA ++ NE++ VK+ K+ ++RE N Sbjct: 75 PLGSGGFATVYEATDVETNEELAVKVFMSEKEPTDETMLDLQRESSCYRNFSLAKTAKDA 134 Query: 93 ----------NIITLAD------IVKDPVSRTP---ALVFEHVN----------NTDFKQ 123 +++ L +V +R L+ D Sbjct: 135 QESCRFMVPSDVVMLEGQPASTEVVIGLTTRWVPNYFLLMMRAEADMSKVISWVFGDASV 194 Query: 124 LYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH 183 + + +K + + GI+H D+KP N ++ + R L L D+G Y Sbjct: 195 NKSEFGLVVRMYLSSQAIKLVANVQAQGIVHTDIKPANFLLLKDGR-LFLGDFG---TYR 250 Query: 184 PGQEYNVRVASRYFKGPELLVDYQM--YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQ 241 + + ++ PE Y + D W LG L + ++ P Sbjct: 251 INNSVGRAIGTPGYEPPERPFQATGITYTFPTDAWQLGITLYCIWCKERP---------- 300 Query: 242 LVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFL 301 ++H + D + Sbjct: 301 ----------------------------------TPADGIWDYLHFADCPSTPELVQDLI 326 Query: 302 DKLLRYDHQSRLTAREAME 320 LL D Q R+ +A+E Sbjct: 327 RSLLNRDPQKRMLPLQALE 345 >4L00-A nrPDB Length = 304 Score = 103 bits (258), Expect = 1e-22, Method: Composition-based stats. Identities = 47/288 (16%), Positives = 87/288 (30%), Gaps = 64/288 (22%) Query: 64 KVVVKILKPVKKKKIKR--EIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDF 121 KV++K+L P + E + +I+ L + V +V E V Sbjct: 62 KVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENI--MVEEFVEGGPL 119 Query: 122 KQLYQT----LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRK------L 171 LT ++ AL Y ++H +V N+++ E + Sbjct: 120 DLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFI 179 Query: 172 RLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEP 231 +L D G+ QE R+ + PE + D + + D WS G L + + E Sbjct: 180 KLSDPGIPITVLSRQECIERI---PWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEI 236 Query: 232 FFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQH 291 + RF + R + Sbjct: 237 PLKDKTLIE-------------------------KERFYESRCRPVTPSCK--------- 262 Query: 292 LVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSM 339 E D + + + YD R P+F +++D ++ + Sbjct: 263 ----ELADLMTRCMNYDPNQR---------PFFRAIMRDINKLEEQNP 297 >5USZ-A nrPDB Length = 289 Score = 103 bits (257), Expect = 1e-22, Method: Composition-based stats. Identities = 37/267 (13%), Positives = 90/267 (33%), Gaps = 35/267 (13%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNE-------KVVVKILKPVKK---KKIKREIKIL 85 +D LG+G ++++F+ + + +V++K+L + + ++ Sbjct: 7 NEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMM 66 Query: 86 ENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT----LTDYDIRFYMYEIL 141 L +++ + LV E V + + ++ Sbjct: 67 SKLSH-KHLVLNYGVC--VCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLA 123 Query: 142 KALDYCHSMGIMHRDVKPHNVMIDHEHRK-------LRLIDWGLAEFYHPGQEYNVRVAS 194 A+ + ++H +V N+++ E + ++L D G++ P R+ Sbjct: 124 AAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERI-- 181 Query: 195 RYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTE-- 252 + PE + + + + + D WS G L + + D+ +L Sbjct: 182 -PWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAP 240 Query: 253 ------DLYDYIDKYNIELDPRFNDIL 273 +L + Y + P F I+ Sbjct: 241 KAAELANLINNCMDYEPDHRPSFRAII 267 >5X1R-A nrPDB Length = 302 Score = 103 bits (256), Expect = 2e-22, Method: Composition-based stats. Identities = 37/227 (16%), Positives = 81/227 (35%), Gaps = 35/227 (15%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK------------------- 77 +++++ +G G + V+ A + + +K P K Sbjct: 21 NEFEIQEAIGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAKRNDDLSIGLRGERFGKTFQ 80 Query: 78 -----IKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY----QTL 128 +E ++L P ++ + ++ + T + + + T K L + + Sbjct: 81 AGLNSFIQEARLLARFSH-PGLLHVLRFWEE--NGTAYMGTQFYSGTTLKNLQAQQPEKI 137 Query: 129 TDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE-FYHPGQE 187 + IR + + A++ H G +HRD+ N+ I + L+D+G A + Sbjct: 138 DEAWIRRLLPPLFSAINTIHQEGYLHRDISLDNIQIQESQLPV-LLDFGSARKEIGNLSD 196 Query: 188 YNVRVASRYFKGPELLVDY--QMYDYSLDMWSLGCMLASMIFRKEPF 232 V F E + D+++LG +L ++I P Sbjct: 197 ETEIVLKPGFAPIEQYTENSDGEQGPWTDIYALGAVLHTLIVGSPPP 243 >5OAT-A nrPDB Length = 411 Score = 96.6 bits (239), Expect = 2e-20, Method: Composition-based stats. Identities = 47/344 (13%), Positives = 101/344 (29%), Gaps = 103/344 (29%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEK-----VVVK-------------ILKPVKKKKI 78 +D L + + +G V+ A + +K ILK + ++ + Sbjct: 11 NDLSLGKPIAKGTNGVVYSAKVKDDETDDNKYPFALKMMFNYDIQENSMEILKAMYRETV 70 Query: 79 KR------------EIKILENLRG---GPNIITLADIVKDPV---------------SRT 108 EI++ + PNI+ + + D + + Sbjct: 71 PARMYYSNHDLNNWEIELANRRKHLPPHPNIVAIFSVFTDLYPAALPPRLHPEGEGRNMS 130 Query: 109 PALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDH-- 166 L+ + + L + + ++L+ + + + GI HRD+K N+++D Sbjct: 131 LFLLMKRYDCNLQSFLSTAPSTRTSLLLLAQLLEGVAHMTAHGIAHRDLKSDNLLLDTSE 190 Query: 167 -EHRKLRLIDWGLAEFYHPG-------QEYNVRVASRYFKGPELLVDYQM------YDYS 212 E L + D+G + + PE++ Y Sbjct: 191 PESPILVISDFGCCLADKTNGLSLPYTSYEMDKGGNTALMAPEIICQKPGTFSVLNYS-K 249 Query: 213 LDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDI 272 D+W++G + + PF+ G L ++ Y P+ D Sbjct: 250 ADLWAVGAIAYEIFNCHNPFY----------------GPSRLKNF--NYKEGDLPKLPDE 291 Query: 273 LGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAR 316 + + + LL+ + RL Sbjct: 292 VPTVIQA--------------------LVANLLKRNPNKRLDPE 315 >6EQI-C nrPDB Length = 433 Score = 95.8 bits (237), Expect = 3e-20, Method: Composition-based stats. Identities = 52/328 (15%), Positives = 112/328 (34%), Gaps = 83/328 (25%) Query: 31 VEWGNQDDYQLVRKLGRGKYSEVFEAI--NITNNE---KVVVKILKPVKKK--------K 77 ++ N D+ L + +G + V+ A N+ +N+ ++ VK++ + Sbjct: 9 LQAANLDELDLGEPIAKGCNAVVYSAKLKNVQSNKLAHQLAVKMMFNYDVESNSTAILKA 68 Query: 78 IKRE------------------IKILE-NLRGGPNIITLADIVKDPV------------- 105 + RE I + L PNI+ + + D + Sbjct: 69 MYRETVPAMSYFFNQNLFNIENISDFKIRLPPHPNIVRMYSVFADRIPDLQCNKQLYPEA 128 Query: 106 ------------SRTPALVFEHVNNTDFKQLYQTLTD--YDIRFYMYEILKALDYCHSMG 151 + + LV + + K+ + T + ++L+A+ + + Sbjct: 129 LPPRINPEGSGRNMSLFLVMKRYD-CTLKEYLRDKTPNMRSSILLLSQLLEAVAHMNIHN 187 Query: 152 IMHRDVKPHNVMIDHEHR----KLRLIDWGLAEFYHPG-------QEYNVRVASRYFKGP 200 I HRD+K N+++D + + D+G E + +R P Sbjct: 188 ISHRDLKSDNILVDLSEGDAYPTIVITDFGCCLCDKQNGLVIPYRSEDQDKGGNRALMAP 247 Query: 201 ELLVDYQM------YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDL 254 E+ Y D+W++G + + PF+ + ++K EDL Sbjct: 248 EIANAKPGTFSWLNY-KKSDLWAVGAIAYEIFNIDNPFYD-----KTMKLLSKSYKEEDL 301 Query: 255 YDYIDKYNIELDPRFNDILGRHSRKRWE 282 + D + +++L R + KR + Sbjct: 302 PELPDTIPFIIRNLVSNMLSRSTNKRLD 329 >3REP-A nrPDB Length = 271 Score = 92.4 bits (228), Expect = 3e-19, Method: Composition-based stats. Identities = 39/210 (18%), Positives = 80/210 (38%), Gaps = 24/210 (11%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILK-----PVKKKKIKREIKILENLRGGP 92 + KL E+++ +VVK+LK K + E L + P Sbjct: 11 QLNFLTKLNENHSGELWKGRWQ--GNDIVVKVLKVRDWSTRKSRDFNEECPRLR-IFSHP 67 Query: 93 NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ-----TLTDYDIRFYMYEILKALDYC 147 N++ + + P + P L+ + + + + ++ + + + Sbjct: 68 NVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFL 127 Query: 148 HSMG-IMHR-DVKPHNVMIDHE-HRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLV 204 H++ ++ R + +VMID + ++ + D + F PG+ Y + + PE L Sbjct: 128 HTLEPLIPRHALNSRSVMIDEDMTARISMADVKFS-FQSPGRMY-----APAWVAPEALQ 181 Query: 205 DYQMYD--YSLDMWSLGCMLASMIFRKEPF 232 S DMWS +L ++ R+ PF Sbjct: 182 KKPEDTNRRSADMWSFAVLLWELVTREVPF 211 >5CLR-A nrPDB Length = 451 Score = 90.1 bits (222), Expect = 2e-18, Method: Composition-based stats. Identities = 31/192 (16%), Positives = 70/192 (36%), Gaps = 23/192 (11%) Query: 54 FEAINITNNEKVVVK--ILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPAL 111 F+ + + + +K + + E L L L + ++ + Sbjct: 96 FKVYALDDGKTYFLKSVKIDAESLTEFTNEKDTLSKLG------RLVGTFFNEQTQVHYI 149 Query: 112 VFEHVNNTDFKQLYQTLTD-------YDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMI 164 + + D + L +++ M + + H +G++HRD+KP N+M+ Sbjct: 150 LTTFIKGIDLSRYKNALPLNVNLKHFWEVLGIMISVCHQVKQFHELGLIHRDLKPGNIML 209 Query: 165 DHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPEL--LVDYQMYDYSLDMWSLGCML 222 D + + L+D+G + + + + PEL D+ + D+++L Sbjct: 210 DAD-MQCHLVDFGSSS--SDKEPKPASWGTASYLAPELNAQEDFIAFSQVSDLFAL---A 263 Query: 223 ASMIFRKEPFFH 234 S+ PF Sbjct: 264 YSLDELFNPFRQ 275 >6J6I-B nrPDB Length = 351 Score = 88.9 bits (219), Expect = 4e-18, Method: Composition-based stats. Identities = 45/221 (20%), Positives = 81/221 (36%), Gaps = 27/221 (12%) Query: 62 NEKVVVKIL-------KPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFE 114 + ++K K + K++ +I + + N + L + P LVFE Sbjct: 81 DRSYMIKRFSEDEITGKRHRVKEVYNDIVLSARMSNHSNFLQLLGCCLEFPF--PVLVFE 138 Query: 115 HVNNTDFKQL-------YQTLTDYDIRF-YMYEILKALDYCHS---MGIMHRDVKPHNVM 163 + Q ++L + +R EI A+ Y H+ I+HRDVKP +V Sbjct: 139 FAEHGAMNQRGGVIVNGEESLLPWSVRLKIGKEIANAVTYLHTAFPKIIIHRDVKPMHVF 198 Query: 164 IDHEHRKLRLIDWGLAEFYHPGQEYNVR---VASRYFKGPELLVDYQMYDYSLDMWSLGC 220 +D ++ +L D + G+ + + + P L D++S G Sbjct: 199 LD-KNWTAKLSDLSFSISLPEGKSRIEAEWVLGTFGYIDP-LYHKTCFVTEYTDVYSFGI 256 Query: 221 MLASMIFRKEPFFHGHDNYDQ--LVRIAKVLGTEDLYDYID 259 L +I K D Q L + ++ L + ID Sbjct: 257 CLLVIITGKPAIMTISDGDLQGILSLVRELCENGKLDEVID 297 >5DMZ-A nrPDB Length = 365 Score = 85.4 bits (210), Expect = 4e-17, Method: Composition-based stats. Identities = 43/247 (17%), Positives = 96/247 (38%), Gaps = 36/247 (14%) Query: 15 VNTHRPREYWDYESHVVEWGNQDDYQLVRKL-------GRGKYSEVFEAI-----NITNN 62 V+++ W + ++ + +QL KL G G +++V+EA + N Sbjct: 38 VSSYPNTFEWQCKLPAIKPKTE--FQLGSKLVYVHHLLGEGAFAQVYEATQGDLNDAKNK 95 Query: 63 EKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFK 122 +K V+K+ KP + +++E L+ + + LV E + Sbjct: 96 QKFVLKVQKPANPWEFYIGTQLMERLKPSMQHMFMKFYSAHLFQNGSVLVGELYSYGTLL 155 Query: 123 QLY--------QTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHE------- 167 + + + + +L ++ H I+H D+KP N ++ + Sbjct: 156 NAINLYKNTPEKVMPQGLVISFAMRMLYMIEQVHDCEIIHGDIKPDNFILGNGFLEQDDE 215 Query: 168 ---HRKLRLIDWGLA---EFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCM 221 L LID G + + + G + + + F+ E+L + + ++Y +D + + Sbjct: 216 DDLSAGLALIDLGQSIDMKLFPKGTIFTAKCETSGFQCVEMLSN-KPWNYQIDYFGVAAT 274 Query: 222 LASMIFR 228 + M+F Sbjct: 275 VYCMLFG 281 >4L68-A nrPDB Length = 340 Score = 83.9 bits (206), Expect = 1e-16, Method: Composition-based stats. Identities = 53/270 (19%), Positives = 103/270 (38%), Gaps = 31/270 (11%) Query: 51 SEVFEAINITNNEKVVVKILKPVK--KKKIKREIKILENLRGGPNIITLADIVKDPVSRT 108 ++A+ + + + VK L K +++ + E+ L LR N+ L V Sbjct: 54 GTTYKAL-LPDGSALAVKHLSTCKLGEREFRYEMNQLWELRHS-NLAPLLGFC--VVEEE 109 Query: 109 PALVFEHVNNTDFKQLY---QTLTDYDIRF-YMYEILKALDYCHSMG---IMHRDVKPHN 161 LV+++++N L + D+ RF + L + H I+H+++ Sbjct: 110 KFLVYKYMSNGTLHSLLDSNRGELDWSTRFRIGLGAARGLAWLHHGCRPPILHQNICSSV 169 Query: 162 VMIDHEHRKLRLIDWGLAEFYHPGQE-----YNVRVASRYFKGPELLVDYQMYDYSLDMW 216 ++ID E R+ID GLA P + + PE + D++ Sbjct: 170 ILID-EDFDARIIDSGLARLMVPSDNNESSFMTGDLGEFGYVAPEY-STTMLASLKGDVY 227 Query: 217 SLGCMLASMIFRKEPF----FHGH--DNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFN 270 LG +L + + F G D QL ++ T D + K + E +F Sbjct: 228 GLGVVLLELATGLKAVGGEGFKGSLVDWVKQLESSGRIAETFD-ENIRGKGHDEEISKFV 286 Query: 271 DI----LGRHSRKRWERFVHSENQHLVSPE 296 +I + ++RW F ++ ++ + Sbjct: 287 EIALNCVSSRPKERWSMFQAYQSLKAIAEK 316 >5C01-A nrPDB Length = 342 Score = 83.5 bits (205), Expect = 1e-16, Method: Composition-based stats. Identities = 37/296 (12%), Positives = 82/296 (27%), Gaps = 69/296 (23%) Query: 56 AINITNNEKVVVKILKPVKKK---KIKREIKILENLRGGPNIITLADIVKDPVSRTPALV 112 + +VV+K+L P ++ + ++ + + +V Sbjct: 101 GRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHT-HLAFVHGVCVRGPENI--MV 157 Query: 113 FEHVNNTDFKQLYQT----LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEH 168 E+V + + + ++ AL Y + ++H +V N+++ Sbjct: 158 TEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLG 217 Query: 169 RK------LRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDY-QMYDYSLDMWSLGCM 221 ++L D G+ +E R+ + PE L ++D W G Sbjct: 218 LAEGTSPFIKLSDPGVGLGALSREERVERI---PWLAPECLPGGANSLSTAMDKWGFGAT 274 Query: 222 LASMIF-RKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKR 280 L + F + P + + F R Sbjct: 275 LLEICFDGEAP--------------------------LQSRSPSEKEHFYQRQHRLPEPS 308 Query: 281 WERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGS 336 + + L Y+ R + F T+++D R+ Sbjct: 309 CPQLAT-------------LTSQCLTYEPTQRPS---------FRTILRDLTRLQP 342 >5UU1-A nrPDB Length = 324 Score = 83.5 bits (205), Expect = 2e-16, Method: Composition-based stats. Identities = 49/315 (15%), Positives = 106/315 (33%), Gaps = 45/315 (14%) Query: 26 YESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK--IKREIK 83 E V++ + + L +K+G G + ++ A EK ++K ++ + E+K Sbjct: 5 PEGKVLDDMEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELK 64 Query: 84 ILENLRGGPNIITLA----------------DIVKDPVSRTPALVFEHVNNTDFKQLYQ- 126 + + I + + +V E + D +++ Sbjct: 65 FYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERL-GIDLQKISGQ 123 Query: 127 --TLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEH-RKLRLIDWGLAEFYH 183 T + +L L+Y H +H D+K N+++ +++ ++ L D+GL+ Y Sbjct: 124 NGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYC 183 Query: 184 PGQEY--------NVRVASRYFKGPELLVDYQMY--DYSLDMWSLGCMLASMIFRKEPFF 233 P + + F L ++ D+ LG + + K P+ Sbjct: 184 PNGNHKQYQENPRKGHNGTIEFTS---LDAHKGVALSRRSDVEILGYCMLRWLCGKLPWE 240 Query: 234 HGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFN--------DILGRHSRKRWERFV 285 + V+ AK ++L + K+ L + ++ Sbjct: 241 QNLKDP-VAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALK 299 Query: 286 HSENQHLVSPEALDF 300 N H + LDF Sbjct: 300 KILNPHGIPLGPLDF 314 >4CI6-B nrPDB Length = 643 Score = 83.1 bits (204), Expect = 2e-16, Method: Composition-based stats. Identities = 50/295 (16%), Positives = 107/295 (36%), Gaps = 49/295 (16%) Query: 57 INITNNEKVVVKILKPVKKKKIKREIKILENL----RGGPNIITLAD--IVKDPVSRTPA 110 I + +++V KI + + + + E++ +++ PN+ + +V A Sbjct: 63 IETKDKQRLVAKIERSIAEGHLFAELEAYKHIYKTAGKHPNLANVHGMAVVPYGNRYYYA 122 Query: 111 LVFEHVNNTDFKQLYQTLTDY-------------DIRFYMYEILKALDYCHSMGIMHRDV 157 L+ + V+ ++L D I+F + +L ++ GI+H D+ Sbjct: 123 LLMDEVDGWRCSDTLRSLADSWKQGKINSEAYWGTIKFIAHRLLDVTNHLAKAGIVHNDI 182 Query: 158 KPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWS 217 KP NV+ D + +ID GL G++ + FK PEL V D++ Sbjct: 183 KPGNVVFDRASGEPVVIDLGL--HSRSGEQPKGF--TESFKAPELGVGNLGASEKSDVF- 237 Query: 218 LGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHS 277 ++++++ E F + + + + +E + + P + ++ Sbjct: 238 --LVVSTLLHGIEGFEKDPEIKP--NQGLRFITSEPAHVMDENGYPIHRPGIAGVETAYT 293 Query: 278 RKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQA 332 R F+ +L SR + EA H + D+ Sbjct: 294 R---------------------FITDILGVSADSRPDSNEARLHEFLSDGTIDEE 327 >4WOV-A nrPDB Length = 317 Score = 82.7 bits (203), Expect = 3e-16, Method: Composition-based stats. Identities = 34/280 (12%), Positives = 76/280 (27%), Gaps = 60/280 (21%) Query: 56 AINITNNEKVVVKILKPVKKK---KIKREIKILENLRGGPNIITLADIVKDPVSRTPALV 112 + +VV+K+L P ++ + ++ + + +V Sbjct: 78 GRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHT-HLAFVHGVCVRGPENI--MV 134 Query: 113 FEHVNNTDFKQLYQT----LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEH 168 E+V + + + ++ AL Y + ++H +V N+++ Sbjct: 135 TEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLG 194 Query: 169 RK------LRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDY-QMYDYSLDMWSLGCM 221 ++L D G+ +E R+ + PE L ++D W G Sbjct: 195 LAEGTSPFIKLSDPGVGLGALSREERVERI---PWLAPECLPGGANSLSTAMDKWGFGAT 251 Query: 222 LASMIF-RKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKR 280 L + F + P + + F R Sbjct: 252 LLEICFDGEAP--------------------------LQSRSPSEKEHFYQRQHRLPEPS 285 Query: 281 WERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAME 320 + + L Y+ R + R + Sbjct: 286 CPQLAT-------------LTSQCLTYEPTQRPSFRTILR 312 >6G4J-A nrPDB Length = 315 Score = 81.6 bits (200), Expect = 5e-16, Method: Composition-based stats. Identities = 46/271 (16%), Positives = 101/271 (37%), Gaps = 20/271 (7%) Query: 35 NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNI 94 N + Y L ++LG+G V+ A T++ V +K+ I E+ +L++ + Sbjct: 24 NGNTYTLRKQLGKGANGIVYLAE--TSDGHVALKV--SDDSLSITSEVNVLKSFSKAQS- 78 Query: 95 ITLADIVKDPVSRTP--------ALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDY 146 +T+ D E++ + I M ++L +L Sbjct: 79 VTMGPSFFDTDDAYIPSANTKVSFYAMEYIKGPLLLKYVSDKGAEWIPVLMIQLLSSLSV 138 Query: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDW-GLAEFYHPGQEYNVRVASRYFKGPELLVD 205 H G + D+KP N+++ ++R ID G + +EY Y+ Sbjct: 139 LHQQGWIFGDLKPDNLIVTGPPARIRCIDVGGTTKEGRAIKEYTEFYDRGYWG-----YG 193 Query: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIEL 265 + + S D++++ ++ + + +KE F + +QL + + Y + Sbjct: 194 TRKAEPSYDLFAVAMIMINSVHKKE-FKKTNQPKEQLRSLIEGNPLLQKYKKALFSALNG 252 Query: 266 DPRFNDILGRHSRKRWERFVHSENQHLVSPE 296 D + D + + ++ + SP+ Sbjct: 253 DYQSADEMKKDMLDAGQKAAQRKQPIKASPQ 283 >4I94-A nrPDB Length = 300 Score = 80.0 bits (196), Expect = 1e-15, Method: Composition-based stats. Identities = 48/277 (17%), Positives = 94/277 (33%), Gaps = 56/277 (20%) Query: 52 EVFEAINITNNEKVVVKILKPV---KKKKIKREIKILENLRGGPNIITLADIVKDPVSRT 108 V++ + N ++ VK ++ E K + LR + L + R Sbjct: 44 VVYKGK-LENQRRIAVKRFNRKSWPDSRQFLEEAKAVGQLRNHR-MANLLGCCYEDEER- 100 Query: 109 PALVFEHVNNTDFKQLY-----QTLTDYDIRFYMYEILKALDYCHSMG-IMHRDVKPHNV 162 L+ E + N + Q + I +AL+YC S G ++ D+ + V Sbjct: 101 -LLIAEFMPNETLAKHLFHWESQPMKWAMRLRVALHIAQALEYCTSKGRALYHDLNAYRV 159 Query: 163 MIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCML 222 + D + RL +GL + G+ Y+ +A F PE L ++ S+ ++S G +L Sbjct: 160 LFDDDANP-RLSCFGLMKNSRDGKSYSTNLA---FTPPEYLRTGRVTPESV-IYSFGTLL 214 Query: 223 ASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWE 282 ++ K + D I NI++ Sbjct: 215 LDLLSGKH------------------IPPSHALDLIRDRNIQM----------------- 239 Query: 283 RFVHSENQHLVSPEALDFLD---KLLRYDHQSRLTAR 316 S + + + + L+Y+ + R + Sbjct: 240 LMDSGLEGQFSSDDGTELIRLASRCLQYEPRERPNPK 276 >2RSV-A nrPDB Length = 403 Score = 79.3 bits (194), Expect = 3e-15, Method: Composition-based stats. Identities = 46/299 (15%), Positives = 111/299 (37%), Gaps = 45/299 (15%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKV------VVKILKPVKKKKIKREIKILENLRGG 91 ++++ +G+G + ++ A ++ ++E V VVK+ +P + E+K + Sbjct: 43 EWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKV-EPSDNGPLFTELKFYQRAAKP 100 Query: 92 PNI--------ITLADI-------VKDPVSR-TPALVFEHVNNTDFKQLY----QTLTDY 131 I + + + D + ++ + +D +++Y + + Sbjct: 101 EQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIYEANAKRFSRK 159 Query: 132 DIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEH-RKLRLIDWGLAEFYHPGQEYNV 190 + IL L+Y H +H D+K N+++++++ ++ L+D+GLA Y P + Sbjct: 160 TVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKE 219 Query: 191 R--------VASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQL 242 + F + D+ LG + + P+ + Sbjct: 220 YKEDPKRCHDGTIEFTSIDAHNGVAP-SRRGDLEILGYCMIQWLTGHLPWEDNLKDPKY- 277 Query: 243 VRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFL 301 VR +K+ E++ +DK E + G ++ + + + D L Sbjct: 278 VRDSKIRYRENIASLMDKCFPE-----KNKPGEIAKYMETVKLLDYTEKPLYENLRDIL 331 >2LAV-A nrPDB Length = 361 Score = 78.1 bits (191), Expect = 6e-15, Method: Composition-based stats. Identities = 46/299 (15%), Positives = 111/299 (37%), Gaps = 45/299 (15%) Query: 38 DYQLVRKLGRGKYSEVFEAINITNNEKV------VVKILKPVKKKKIKREIKILENLRGG 91 ++++ +G+G + ++ A ++ ++E V VVK+ +P + E+K + Sbjct: 36 EWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKV-EPSDNGPLFTELKFYQRAAKP 93 Query: 92 PNI--------ITLADI-------VKDPVSR-TPALVFEHVNNTDFKQLY----QTLTDY 131 I + + + D + ++ + +D +++Y + + Sbjct: 94 EQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIYEANAKRFSRK 152 Query: 132 DIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEH-RKLRLIDWGLAEFYHPGQEYNV 190 + IL L+Y H +H D+K N+++++++ ++ L+D+GLA Y P + Sbjct: 153 TVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKE 212 Query: 191 R--------VASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQL 242 + F + D+ LG + + P+ + Sbjct: 213 YKEDPKRCHDGTIEFTSIDAHNGVAP-SRRGDLEILGYCMIQWLTGHLPWEDNLKDPKY- 270 Query: 243 VRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFL 301 VR +K+ E++ +DK E + G ++ + + + D L Sbjct: 271 VRDSKIRYRENIASLMDKCFPE-----KNKPGEIAKYMETVKLLDYTEKPLYENLRDIL 324 >4IX6-A nrPDB Length = 350 Score = 78.1 bits (191), Expect = 6e-15, Method: Composition-based stats. Identities = 56/338 (16%), Positives = 97/338 (28%), Gaps = 83/338 (24%) Query: 44 KLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNII-------- 95 LG G + VF + + + V LK K + E ++LE + Sbjct: 27 PLGSGNFGTVFRGVFKGDQDVV----LKNAKADVMAAE-ELLECEMDVNYHVHANAKGTC 81 Query: 96 -TLADIVK----DPVSRTPALVFE-----HVNNTD----------------FKQLYQTLT 129 ++ D + E N + Sbjct: 82 ARFMGCIELGAKDGGEIYNGTLTEGLWLMWANEGENTVEALMRRGTAPLATAMACADATE 141 Query: 130 DYDIRFYMYEILKALDYCHSMGIMHRDVKPHN-VMIDHEHRKLRLIDWGLAEFYHPGQEY 188 + M E+L +L H G++HRDVKP N + + + L+LID G A P E Sbjct: 142 LGVTKKAMRELLGSLARLHECGVVHRDVKPANLIAAEKDGGVLKLIDLGAAALCLPLPET 201 Query: 189 ------NVRVASRYFKGPELLVDYQMYDYSL----------------DMWSLGCMLASMI 226 + RY K EL + D WS GC++ + Sbjct: 202 LNYYPGDGPADPRYAKADELYLLPPGSPRPTKDNAAKLWEAHKPDRFDSWSAGCVMLQLA 261 Query: 227 FRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVH 286 V + G E +++ + G + + Sbjct: 262 V---------------VGLRTDAGLERFLADYKAVGYDVNAFRGEKSGEYGTMDFAALDA 306 Query: 287 SENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 + D +L+ + +R + A+ H +F Sbjct: 307 NGGAGW------DLCQRLMEAERDARASCEAALSHAFF 338 >4O1O-A nrPDB Length = 717 Score = 69.3 bits (168), Expect = 3e-12, Method: Composition-based stats. Identities = 27/158 (17%), Positives = 61/158 (38%), Gaps = 13/158 (8%) Query: 24 WDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIK 83 W ++ ++Y++ G ++ + +++V VK + ++E+ Sbjct: 337 WRPMIGKLKIFIDEEYKIADT-AEGG---IYLG--LYEDQEVAVKRFSEGSTRG-QQEVS 389 Query: 84 ILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT-----LTDYDIRFYMY 138 L++ R N++T D L + ++ D R + Sbjct: 390 CLQSSRANDNVVTFYGSESDGSCLHVCLALCEYTLQEHLANHRGDAVPNEEDESARNILS 449 Query: 139 EILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDW 176 + KA+ H G H+D++P N++ID ++ L D+ Sbjct: 450 SLFKAIGELHRSGYSHQDLQPQNILIDSKNGTF-LADF 486 Score = 31.1 bits (69), Expect = 0.79, Method: Composition-based stats. Identities = 8/35 (22%), Positives = 17/35 (48%), Gaps = 4/35 (11%) Query: 294 SPEALDFLDKLLR--YDHQSRLTAREAMEHPYFYT 326 E D + L + + RL++ + HP+F++ Sbjct: 538 DEETRDLIHHLFHPGDNVEDRLSS--LLAHPFFWS 570 >2JII-A nrPDB Length = 352 Score = 63.9 bits (154), Expect = 1e-10, Method: Composition-based stats. Identities = 36/201 (17%), Positives = 77/201 (38%), Gaps = 26/201 (12%) Query: 126 QTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHR-KLRLIDWGLAEFYHP 184 L++ + +L AL++ H +H +V N+ +D E + ++ L +G A Y P Sbjct: 154 HVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVDPEDQSQVTLAGYGFAFRYCP 213 Query: 185 GQEYNVRV--------ASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGH 236 ++ V F +L D+ SLG + ++ P+ + Sbjct: 214 SGKHVAYVEGSRSPHEGDLEFISMDLHKGCGP-SRRSDLQSLGYCMLKWLYGFLPWTNCL 272 Query: 237 DNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPE 296 N + +++ + ++DK + P + I + +++ + V + P Sbjct: 273 PNTEDIMKQKQ--------KFVDKPGPFVGPCGHWIRPSETLQKYLKVVMALTYEEKPPY 324 Query: 297 A--LDFLDKLLR------YDH 309 A + L+ LL+ YD Sbjct: 325 AMLRNNLEALLQDLRVSPYDP 345 >4OAU-C nrPDB Length = 699 Score = 63.5 bits (153), Expect = 2e-10, Method: Composition-based stats. Identities = 35/181 (19%), Positives = 69/181 (38%), Gaps = 28/181 (15%) Query: 18 HRPREYWDYESHVVEWGNQDDYQLVRK-LGRGKY-------------SEVFEAINITNNE 63 H P E W +S +D +++ R +G+ K+ ++ + Sbjct: 310 HPPAEDWKPQSSHWGAALKDLHRIYRPMIGKLKFFIDEKYKIADTSEGGIYLGF--YEKQ 367 Query: 64 KVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNT---- 119 +V VK + +RE+ L++ R +++T + + T Sbjct: 368 EVAVKTF-CEGSPRAQREVSCLQSSRENSHLVTFYGS--ESHRGHLFVCVTLCEQTLEAC 424 Query: 120 -DFKQLYQTLTDYD--IRFYMYEILKALDYCH-SMGIMHRDVKPHNVMIDHEHRKLRLID 175 D + + D R + I KA+ H S G H+D++P N++ID + + L D Sbjct: 425 LDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSK-KAAHLAD 483 Query: 176 W 176 + Sbjct: 484 F 484 Score = 30.3 bits (67), Expect = 1.4, Method: Composition-based stats. Identities = 14/70 (20%), Positives = 27/70 (38%), Gaps = 3/70 (4%) Query: 294 SPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMS 353 E D + +L R + + HP+F+T ++R + G + + + S Sbjct: 536 DEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTW---ESRYRTLRNVGNESDIKTRKSES 592 Query: 354 GISSVPTPSP 363 I + P P Sbjct: 593 EILRLLQPGP 602 >4CYJ-A nrPDB Length = 438 Score = 57.7 bits (138), Expect = 9e-09, Method: Composition-based stats. Identities = 29/163 (17%), Positives = 63/163 (38%), Gaps = 41/163 (25%) Query: 50 YSE---VFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGP-----NIITLADIV 101 + V++A N N L+ ++ ++ E IL ++ +I+T+ ++ Sbjct: 65 FGYPSWVYKAQNSRNGRHYA---LRRLEGYRLTNEKAILNVMKDWKKIKNASIVTIHEVF 121 Query: 102 KDPVSRTPALVFEHVNNTDFKQLYQTLTDYD-------------------IRFYMYEILK 142 +L+F + DF L +TL ++ I Y+ +I Sbjct: 122 TTREFGDSSLIFAY----DFHPLSKTLQEHHFQPIHGNRYRPPPAVPENTIWGYICQIAN 177 Query: 143 ALDYCHSMGIMHRDVKPHNVMIDHEHR----KLRLID---WGL 178 AL HS + R ++P +++ +R ++D +G+ Sbjct: 178 ALKTIHSNRLAARCLEPSKIILTDINRIRLSACAILDVVQFGM 220 >6EWX-A nrPDB Length = 484 Score = 57.7 bits (138), Expect = 9e-09, Method: Composition-based stats. Identities = 34/231 (14%), Positives = 64/231 (27%), Gaps = 78/231 (33%) Query: 130 DYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRK------------------- 170 + + F + ++ L++ GI+HRD+ N+++ H + + Sbjct: 209 ERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLVHCNPQSSPGPSANPSVPTTTSRCP 268 Query: 171 ---------------------LRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMY 209 L + ++ A+ G + S+ PE++ Q Sbjct: 269 SAAPAATTACQGGPGEKHLPRLIISNFLKAKQKPGGTTNLQQKKSQARLAPEIVSASQY- 327 Query: 210 DYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRF 269 D + G ++ ++ + PF + QL Sbjct: 328 -RKFDEFQTGILIYELLHQPNPF----EVRAQL--------------------------- 355 Query: 270 NDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAME 320 R R E L SP LL D R+ EA Sbjct: 356 -----RERDYRREDLPPLPTLSLYSPGLQQLAHLLLEADPIKRIRIGEAKR 401 >5GZA-A nrPDB Length = 290 Score = 56.5 bits (135), Expect = 2e-08, Method: Composition-based stats. Identities = 36/208 (17%), Positives = 67/208 (32%), Gaps = 38/208 (18%) Query: 40 QLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK-KKKIKREIKILENLRGGPNIITLA 98 + V+ +G+G +V+ + +KV + +L + + +L L+ +++TL Sbjct: 28 RRVKLIGQGAVKKVYLSEWQ--GQKVALSVLSSDQYADDFLHGLSMLRALQSS-HVVTLV 84 Query: 99 DIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRF---YMYEILKALDYCHSMGIMHR 155 + ++ V E+ L TL R+ + + A+DY + +H Sbjct: 85 GVCEEDA----VFVTEYHPLGSVLTLDTTLAQERYRWRNSWHTRLQLAIDYVAFLAYLHS 140 Query: 156 DVKPHNVMIDHEHRKLRLIDWGLAEFYH------------PGQEYNVRVA----SRYFKG 199 VM D L + LA V+ + F Sbjct: 141 SPAGIRVMCDSNDLHKTLSQFLLASDMRLLANDLDALPEVEKGGLGVKCGHHELTGDFVA 200 Query: 200 PELL-----------VDYQMYDYSLDMW 216 PE L YD D+W Sbjct: 201 PEQLWPYGEDFSFSDEAMPGYDEKTDIW 228 >5GZ9-A nrPDB Length = 305 Score = 56.2 bits (134), Expect = 2e-08, Method: Composition-based stats. Identities = 32/213 (15%), Positives = 77/213 (36%), Gaps = 39/213 (18%) Query: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL-KPVKKKKIKREIKILENLRGGPNI 94 + + + ++++G G VF + KV + L + K+ +++L++L+ ++ Sbjct: 33 RTEVRQLKRVGEGAVKRVFLSEWKE--HKVALSRLTRLEMKEDFLHGLQMLKSLQ-SEHV 89 Query: 95 ITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTD---YDIRFYMYEILKALDYCHSMG 151 +TL ++ + ++ E+ L +TL D+ + + + A++Y + Sbjct: 90 VTLVGYCEEDGT----ILTEYHPLGSLSNLEETLQLSKYQDVNTWQHRLQLAMEYVSIIN 145 Query: 152 IMH------RDVKPHNVM-------IDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY-- 196 +H R + N + + + + D ++ R Sbjct: 146 YLHHSPLGTRVMCDSNDLPKTLSQYLLTSNFSIVANDLDALPLVDHDSGVLIKCGHRELH 205 Query: 197 --FKGPELLVDYQ-----------MYDYSLDMW 216 F PE L Y Y+ +D+W Sbjct: 206 GDFVAPEQLWPYGEDTPFQDDLMPSYNEKVDIW 238 >4AZW-A nrPDB Length = 471 Score = 52.7 bits (125), Expect = 3e-07, Method: Composition-based stats. Identities = 28/114 (24%), Positives = 43/114 (37%), Gaps = 23/114 (20%) Query: 74 KKKKIKREIKILEN----------LRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQ 123 K ++ EIK L L G N +++ LV E + Sbjct: 284 NKHELHNEIKFLTQPPAGFDAPAVLAHGEN------------AQSGWLVMEKLPGRLLSD 331 Query: 124 LYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWG 177 + + D + +L++L G H DV+P NVM+D RLID+G Sbjct: 332 MLAAGEEIDREKILGSLLRSLAALEKKGFWHDDVRPWNVMVDARQHA-RLIDFG 384 >6M7Z-A nrPDB Length = 319 Score = 52.7 bits (125), Expect = 3e-07, Method: Composition-based stats. Identities = 37/255 (14%), Positives = 79/255 (30%), Gaps = 64/255 (25%) Query: 97 LADIVKDPVSRTPALVFEHVNNTDFKQLYQT-LTDYDIRFYMYEILKALDYCHSMGIMHR 155 L + + +F ++ + +T + D++ ++ AL H++G++HR Sbjct: 109 LLPSLGEYRGAFLTYIFHPLSKGLVGDMLETGRSHPDVQVLAANMVAALKSLHNLGLLHR 168 Query: 156 DVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYF---KGPEL--------LV 204 ++ N + L GL G E + V +F PE+ + Sbjct: 169 SIEL-NSFSVLPDGTVVLG--GLDTAAPIGTETRLWVG--FFGQETAPEIDRNFLADLAL 223 Query: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIE 264 + D++SLG + ++LG N Sbjct: 224 TQGRHTVKSDVYSLGV--------------------AFRNLVQLLG-----------NGN 252 Query: 265 LDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 L P + + + ++ K++ + +R T E M+ P F Sbjct: 253 LGPEDRGAVRQDHLELLDK----------------LSQKMIEEEPGNRPTIEEIMKDPLF 296 Query: 325 YTVVKDQARMGSSSM 339 + + G + Sbjct: 297 EGLNFEDIEEGKARP 311 >6EAS-A nrPDB Length = 308 Score = 52.3 bits (124), Expect = 4e-07, Method: Composition-based stats. Identities = 33/280 (11%), Positives = 84/280 (30%), Gaps = 55/280 (19%) Query: 54 FEAINITNNEKVVV--------KILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPV 105 ++ +++ ++ V K + + +++I L + N + L ++ Sbjct: 57 YKGT-LSSGVEIAVASSLVTSAKDWSKENESQYRKKITNLSKVSH-KNFMNLLGYCEEEH 114 Query: 106 SRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMY-----EILKALDYCHSMGI--MHRDVK 158 T +VFE+ N + + + I L++ H + R+ Sbjct: 115 PFTRVMVFEYAPNGTLFEHLHVREAEKLDWMARLRISMGIAYCLEHMHQLQTPAALRNFD 174 Query: 159 PHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSL 218 V + + ++ D EF++ + +N + P++ + Y Sbjct: 175 STTVYLT-DDFAAKVSDL---EFWNDAKGHNSTTNNELAFSPDMEDIVRKY--------- 221 Query: 219 GCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSR 278 G +L ++ + P + V ++ + +DP +R Sbjct: 222 GMVLLEILTGRVPSSEDDGPLENWV--------SRYFEGGMRLEELIDPSIGFFPEDTAR 273 Query: 279 KRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREA 318 E + + D + R +E Sbjct: 274 ALCEV-----------------VRSCIDRDPKKRPQMKEV 296 >4AZV-A nrPDB Length = 569 Score = 52.3 bits (124), Expect = 4e-07, Method: Composition-based stats. Identities = 28/114 (24%), Positives = 43/114 (37%), Gaps = 23/114 (20%) Query: 74 KKKKIKREIKILEN----------LRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQ 123 K ++ EIK L L G N +++ LV E + Sbjct: 284 NKYELHNEIKFLTQPPAGFDAPAVLAHGEN------------AQSGWLVMEKLPGRLLSD 331 Query: 124 LYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWG 177 + + D + +L++L G H DV+P NVM+D RLID+G Sbjct: 332 MLAAGEEIDREKILGSLLRSLAALEKQGFWHDDVRPWNVMVDARQHA-RLIDFG 384 >6BHC-A nrPDB Length = 438 Score = 49.2 bits (116), Expect = 3e-06, Method: Composition-based stats. Identities = 29/197 (14%), Positives = 61/197 (30%), Gaps = 36/197 (18%) Query: 128 LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE 187 L + + + ++ L++ + H D++ N+++ H +G AE Sbjct: 175 LYERQVCLLLLQLCSGLEHLKPYHVTHCDLRLENLLLVHYQPGGTAQGFGPAEPTPTSSY 234 Query: 188 YNVRVAS-------------RYF------KGPELLVDYQMYDYSLDMWSLGCMLASMIFR 228 + S PE++ Q D + G ++ M+ Sbjct: 235 PTRLIVSNFSQAKQKSHLVDPEILRDQSRLAPEIITATQY--KKCDEFQTGILIYEMLHL 292 Query: 229 KEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSE 288 PF D +L E Y D I ++ L + + + Sbjct: 293 PNPF----DENPELK--------EREYTRADLPRIPFRSPYSRGLQQLASCL---LNPNP 337 Query: 289 NQHLVSPEALDFLDKLL 305 ++ ++ +A L LL Sbjct: 338 SERILISDAKGILQCLL 354 >5VE6-A nrPDB Length = 492 Score = 49.2 bits (116), Expect = 3e-06, Method: Composition-based stats. Identities = 9/37 (24%), Positives = 21/37 (56%) Query: 130 DYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDH 166 + + F + ++ L++ GI+HRD+ N+++ H Sbjct: 207 ERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLVH 243 Score = 34.2 bits (77), Expect = 0.10, Method: Composition-based stats. Identities = 21/123 (17%), Positives = 31/123 (25%), Gaps = 38/123 (30%) Query: 198 KGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDY 257 PE++ Q D + G ++ ++ + PF + QL Sbjct: 325 LAPEIVSASQY--RKFDEFQTGILIYELLHQPNPF----EVRAQL--------------- 363 Query: 258 IDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTARE 317 R R E L SP LL D R+ E Sbjct: 364 -----------------RERDYRQEDLPPLPALSLYSPGLQQLAHLLLEADPIKRIRIGE 406 Query: 318 AME 320 A Sbjct: 407 AKR 409 >3ENH-A nrPDB Length = 540 Score = 49.2 bits (116), Expect = 3e-06, Method: Composition-based stats. Identities = 26/154 (16%), Positives = 62/154 (40%), Gaps = 24/154 (15%) Query: 45 LGRGKYSEVFEAINITNNEKVVVK-ILKP----------VKKKKIKREIKILENLRGGPN 93 +G+G +++ + + V++K +K ++K + RE + L ++ Sbjct: 344 IGKGAEADIK--RDSYLDFDVIIKERVKKGYRDERLDENIRKSRTAREARYLALVKD--F 399 Query: 94 IITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIM 153 I I + + ++N K + + D Y+I + + H ++ Sbjct: 400 GIPAPYIFDVDLDNKRIM-MSYINGKLAKDVIE-----DNLDIAYKIGEIVGKLHKNDVI 453 Query: 154 HRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE 187 H D+ N + D + L +ID+GL + + ++ Sbjct: 454 HNDLTTSNFIFDKD---LYIIDFGLGKISNLDED 484 >1TQM-A nrPDB Length = 282 Score = 48.5 bits (114), Expect = 5e-06, Method: Composition-based stats. Identities = 34/157 (21%), Positives = 64/157 (40%), Gaps = 35/157 (22%) Query: 41 LVRKLGRGKYSEVFEAINITNNEKVVVKI-------LKPVKKKK--------------IK 79 + + +G GK S VF + E V VK K VK+K+ + Sbjct: 94 IGKLMGEGKESAVFNCYSEKFGECV-VKFHKVGHTSFKKVKEKRDYGDLHFSVLAIRSAR 152 Query: 80 REIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYE 139 E + L+ L+G + K A++ E ++ + ++ D + + E Sbjct: 153 NEFRALQKLQG-------LAVPKVYAWEGNAVLMELIDAKELYRVRVENPDEVLDMILEE 205 Query: 140 ILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDW 176 + K + H GI+H D+ +NV++ E + +ID+ Sbjct: 206 VAK---FYH-RGIVHGDLSQYNVLVSEEG--IWIIDF 236 >6G38-A nrPDB Length = 357 Score = 48.5 bits (114), Expect = 5e-06, Method: Composition-based stats. Identities = 37/221 (16%), Positives = 67/221 (30%), Gaps = 77/221 (34%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKIL-----------KPVKKKKIKREIKIL 85 + Q K+G G + EVF I ++ V +KI+ ++I EI I Sbjct: 41 EKLQRCEKIGEGVFGEVF--QTIADHTPVAIKIIAIEGPDLVNGSHQKTFEEILPEIIIS 98 Query: 86 ENLR----------------GGPNIIT-----LA------------------DIVKDPVS 106 + L + + L D KD Sbjct: 99 KELSLLSGEVCNRTEGFIGLNSVHCVQGSYPPLLLKAWDHYNSTKGSANDRPDFFKD--- 155 Query: 107 RTPALVFEH-VNNTDFKQLYQTL-TDYDIRFYMYEILKALDYCH-SMGIMHRDVKPHNVM 163 +V E D +Q+ L + + ++++ +L S+ HRD+ NV+ Sbjct: 156 DQLFIVLEFEFGGIDLEQMRTKLSSLATAKSILHQLTASLAVAEASLRFEHRDLHWGNVL 215 Query: 164 -------------------IDHEHRKLRLIDWGLAEFYHPG 185 I ++ +ID+ L+ G Sbjct: 216 LKKTSLKKLHYTLNGKSSTIPSCGLQVSIIDYTLSRLERDG 256 >4WWA-A nrPDB Length = 261 Score = 45.4 bits (106), Expect = 4e-05, Method: Composition-based stats. Identities = 26/151 (17%), Positives = 54/151 (35%), Gaps = 29/151 (19%) Query: 54 FEAINITNNEKVVVKILKPVK-----------KKKIKREIKILENLRGGPN--IITLADI 100 + +++K ++K P + K + E ++L L P + L Sbjct: 38 YLPRAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIAC 97 Query: 101 VKDPVSRTPALVF--EHVNNT----DFKQLYQTLTDYD-----IRFYMYEILKALDYCHS 149 DP + L F E + + K + D D + + ++ + + H Sbjct: 98 --DPYNGFIWLEFLGEDLPGGHGFSNLKNFL-WMHDQDPYSDLVATTLRKVGRQIGLLHW 154 Query: 150 MGIMHRDVKPHNVMIDHEHRKL--RLIDWGL 178 H D+ N+++ + + LID+GL Sbjct: 155 NDYCHGDLTSSNIVLVRDGARWTPHLIDFGL 185 >4CZY-B nrPDB Length = 429 Score = 45.0 bits (105), Expect = 6e-05, Method: Composition-based stats. Identities = 22/142 (15%), Positives = 54/142 (38%), Gaps = 26/142 (18%) Query: 54 FEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGP-----NIITLADIVKDPVSRT 108 ++A N N L+ ++ ++ E IL + NI+T+ + Sbjct: 61 YKAQNNKNGRHFA---LRRIEGYRLTNEKAILNVTKEWKKIINANIVTVHEAFTTEFFGD 117 Query: 109 PALVFEH----VNNTDFKQLY------------QTLTDYDIRFYMYEILKALDYCHSMGI 152 +L+F + ++ T + + + + + Y+ +I AL H+ + Sbjct: 118 SSLIFVYDFHPLSETLYDHHFPPNNSHNRLRNTNKIPENLLWSYVCQIANALLAIHNAKL 177 Query: 153 MHRDVKPHNVMIDHEHRKLRLI 174 R ++ ++ E+ ++RL Sbjct: 178 AARCLELSKII--WENNRIRLA 197 >2W1Z-A nrPDB Length = 368 Score = 43.1 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 49/325 (15%), Positives = 98/325 (30%), Gaps = 71/325 (21%) Query: 33 WGNQDDYQLVRKLGR--------------GKYSEVFEAINITNNEKV------------- 65 W N+ +++ +LG G Y EA + E + Sbjct: 41 WRNEQSFRVESELGERPRTLVRGPVLRDDGSY-ICLEATDQETGEPLEVHVPYFTERPPS 99 Query: 66 -VVKILKP-VKKKKIKREIKILENLRGGPNIITLADIVKDP---------VSRTPALVF- 113 +K L V + ++ R IK + I D+VKDP + V Sbjct: 100 NAIKQLSEQVLRLRLLRGIKNQRQAKAYLRFIFPIDLVKDPKKRKMIRVRLDERDMWVLS 159 Query: 114 -----------EHVNNTDFKQL---YQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKP 159 H+ +++L + ++++ G++H D + Sbjct: 160 RFFLYPRMQSNLHILGDVLLSHSSTHKSLVHHARLQLTLQLIRLAASLQHYGLVHADFQV 219 Query: 160 HNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPE-----LLVDYQMY----D 210 N+++D + L G G + R F PE +L Q + Sbjct: 220 RNILLDQRGG-VFLT--GFEHLVRDGASAVSPIG-RGFAPPETTAERMLPYRQHHPTLMT 275 Query: 211 YSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFN 270 + D W+LG + + P + +L I + + +E R++ Sbjct: 276 FPFDTWTLGLAIYWIWCADLP----NTEDAELGGIEWIYRRCKNIPQPVRALLEGFLRYS 331 Query: 271 DILGRHSRKRWERFVHSENQHLVSP 295 + E + + + +S Sbjct: 332 KEDRLLPLQAMETSEYEQLRTELSA 356 >3BYV-A nrPDB Length = 377 Score = 42.7 bits (99), Expect = 3e-04, Method: Composition-based stats. Identities = 41/228 (17%), Positives = 79/228 (34%), Gaps = 57/228 (25%) Query: 55 EAINITNNEKV--------------VVKILKP-VKKKKIKREIKILENLRGGPNIITLAD 99 EA + E +K +K V + ++ R IK + + I D Sbjct: 91 EATDQETGESFEVHVPYFTERPPSNAIKQMKEEVLRLRLLRGIKNQKQAKVHLRFIFPFD 150 Query: 100 IVKDPVSRTPALVFEHVNNTDFKQL--------------------------YQTLTDYDI 133 +VKDP + V ++ D L +++L + Sbjct: 151 LVKDPQKKKMIRV--RLDERDMWVLSRFFLYPRMQSNLQTFGEVLLSHSSTHKSLVHHAR 208 Query: 134 RFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVA 193 ++++ L H G++H ++P ++++D + L G G V Sbjct: 209 LQLTLQVIRLLASLHHYGLVHTYLRPVDIVLDQRGG-VFLT--GFEHLVRDGARVVSSV- 264 Query: 194 SRYFKGPEL------LVDYQMY----DYSLDMWSLGCMLASMIFRKEP 231 SR F+ PEL + ++ +S D W+LG ++ + P Sbjct: 265 SRGFEPPELEARRATISYHRDRRTLMTFSFDAWALGLVIYWIWCADLP 312 >3DZO-A nrPDB Length = 413 Score = 41.1 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 45/263 (17%), Positives = 87/263 (33%), Gaps = 71/263 (26%) Query: 33 WGNQDDYQLVRKLG-------RGK-------YSEVFEAINITNNEKV------------- 65 W +++ +LG RG Y+ EA + E Sbjct: 61 WNTGQPFRVESELGERPRTLVRGTVLGQEDPYAY-LEATDQETGESFEVHVPYFTERPPS 119 Query: 66 -VVKILKP-VKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQ 123 +K +K V + ++ R IK + + I D+VKDP + V ++ D Sbjct: 120 NAIKQMKEEVLRLRLLRGIKNQKQAKVHLRFIFPFDLVKDPQKKKMIRV--RLDERDMWV 177 Query: 124 L--------------------------YQTLTDYDIRFYMYEILKALDYCHSMGIMHRDV 157 L +++L + ++++ L H G++H + Sbjct: 178 LSRFFLYPRMQSNLQTFGEVLLSHSSTHKSLVHHARLQLTLQVIRLLASLHHYGLVHTYL 237 Query: 158 KPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPE-----LLVDYQMY--- 209 +P ++++D + L G G + R F PE +L Q + Sbjct: 238 RPVDIVLDQRGG-VFLT--GFEHLVRDGASAVSPIG-RGFAPPETTAERMLPFGQHHPTL 293 Query: 210 -DYSLDMWSLGCMLASMIFRKEP 231 ++ D W+LG + + P Sbjct: 294 MTFAFDTWTLGLAIYWIWCADLP 316 >4BVU-A nrPDB Length = 211 Score = 39.6 bits (91), Expect = 0.003, Method: Composition-based stats. Identities = 26/161 (16%), Positives = 60/161 (37%), Gaps = 16/161 (9%) Query: 21 REYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIK- 79 + + +E++ G + L + +G+G +E+FE +N ++ ++ + ++ Sbjct: 24 QTPFPFENNNSHAGIVTEPILGKLIGQGSTAEIFEDVNDSSALYKKYDLIGNQYNEILEM 83 Query: 80 --REIKILENLRGGPN--IITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRF 135 +E ++ G +I L V T + +I Sbjct: 84 AWQESELFNAFYGDEASVVIQYGG--------DVYLRMLRVPGTPLSDIDTADIPDNIES 135 Query: 136 YMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDW 176 +++ L+ I+H D+ N++ D E L ID+ Sbjct: 136 LYLQLICKLNEL---SIIHYDLNTGNMLYDKESESLFPIDF 173 >3Q60-A nrPDB Length = 371 Score = 39.2 bits (90), Expect = 0.003, Method: Composition-based stats. Identities = 39/220 (17%), Positives = 75/220 (34%), Gaps = 34/220 (15%) Query: 120 DFKQLYQTLTDYDIRFYM-YEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGL 178 DF +++ + ++++ S G++H P N+ I + R L L D + Sbjct: 182 DFVYVFRGDEGILALHILTAQLIRLAANLQSKGLVHGHFTPDNLFIMPDGR-LMLGD--V 238 Query: 179 AEFYHPGQEYNVRVASRYFKGPELLVDYQ-MYDYSLDMWSLGCMLASMIFRKEPFFHGHD 237 + + G + E L + ++L+ W LG + + PF Sbjct: 239 SALWKVGTRGPASSVPVTYAPREFLNASTATFTHALNAWQLGLSIYRVWCLFLPF----- 293 Query: 238 NYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEA 297 L T + + ++ + D L S FV + Sbjct: 294 ----------GLVTPGIKGSWKRPSLRVPGT--DSLAFGSCTPLPDFVKT---------- 331 Query: 298 LDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSS 337 + + L +D + RL EAME P F + + + S+ Sbjct: 332 --LIGRFLNFDRRRRLLPLEAMETPEFLQLQNEISSSLST 369 >5YK0-A nrPDB Length = 452 Score = 38.4 bits (88), Expect = 0.005, Method: Composition-based stats. Identities = 31/168 (18%), Positives = 61/168 (36%), Gaps = 43/168 (25%) Query: 51 SEVFEAINITNNEKVVVKILKP-------VKKKKIKREIKILENLRGGPNIITLADIVKD 103 +V +AI ++ +V VKI P K ++R + +L+ L G ++ + D + + Sbjct: 146 GQVHKAIW-SDGREVAVKIQYPGADEALRADLKTMQRMVGVLKQLSPGADVQGVVDELVE 204 Query: 104 PVSRTPALVFEHVNNTDFKQLYQTLTDYDI--------RFYMYEILKAL----------- 144 E N F + Y + + + + E ++ + Sbjct: 205 RTEMELDYRLEAANQRAFAKAYHDHPRFQVPHVVASAPKVVIQEWIEGVPMAEIIRHGTT 264 Query: 145 ---------------DYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWG 177 D +G+MH D P N M+ + R + +ID+G Sbjct: 265 EQRDLIGTLLAELTFDAPRRLGLMHGDAHPGNFMLLPDGR-MGIIDFG 311 >4BWP-A nrPDB Length = 448 Score = 37.3 bits (85), Expect = 0.012, Method: Composition-based stats. Identities = 16/163 (9%), Positives = 50/163 (30%), Gaps = 42/163 (25%) Query: 54 FEAINITNNEKVVVKIL--KPVKKKKIKREIKILENLRGGPNIITLADIVKDP--VSRTP 109 + A + T K ++ + ++ K +++ + L+ N++ L ++ + Sbjct: 67 YRATHNTTGYKYCLRRIHGFRLQSTKCMTLVEMWKKLQHT-NVVQLREVFTTKAFGDNSL 125 Query: 110 ALVFEHVNN-----------------------TDFKQLYQT-----------LTDYDIRF 135 LV+++ + + L + I Sbjct: 126 VLVYDYHPGSQTLLAKYFTPAPETNGYTDPFQGEARPFSHKSNMQRTSNGPLLPEATIWS 185 Query: 136 YMYEILKALDYCHSMGIMHRDVKPHNVMIDHEH---RKLRLID 175 + ++ L H G+ + + P +++ + + D Sbjct: 186 IIMQLTAGLKAIHHAGLACKVLDPTKIIVTGKRVRFSSCCISD 228 >6G18-v nrPDB Length = 552 Score = 36.1 bits (82), Expect = 0.028, Method: Composition-based stats. Identities = 18/99 (18%), Positives = 38/99 (38%), Gaps = 9/99 (9%) Query: 78 IKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYM 137 +E ++ L + K A+V E +N Q++ + Sbjct: 158 AMKEFAYMKALYERKFPVP-----KPIDYNRHAVVMELINGYPLCQIHHVEDPASVYDEA 212 Query: 138 YEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDW 176 E++ L + G++H D N+++D E + +ID+ Sbjct: 213 MELIVKLA---NHGLIHGDFNEFNLILD-ESDHITMIDF 247 >5I35-A nrPDB Length = 393 Score = 36.1 bits (82), Expect = 0.029, Method: Composition-based stats. Identities = 28/175 (16%), Positives = 49/175 (28%), Gaps = 43/175 (24%) Query: 51 SEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNII-------TLADIVK- 102 +V A + +V +KI P + I ++ L + N++ L D+++ Sbjct: 88 GQVHLAR-MKGGREVAMKIQYPGVAQSINSDVNNLMAVLNMSNMLPEGLFPEHLIDVLRR 146 Query: 103 ------------------------DPVSRTPALVFEHVNNTDF-KQLYQTLTDYDIRFYM 137 P P +V E + +L Sbjct: 147 ELALECDYQREAACARKFRDLLKGHPFFYVPEIVDELCSPHVLTTELVSGFPLDQAEGLS 206 Query: 138 YEI---------LKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH 183 EI + L M D N D + K+ L+D+G Y Sbjct: 207 QEIRNEICYNILVLCLRELFEFHFMQTDPNWSNFFYDPQQHKVALLDFGATREYD 261 >6FDN-A nrPDB Length = 320 Score = 35.4 bits (80), Expect = 0.048, Method: Composition-based stats. Identities = 18/99 (18%), Positives = 38/99 (38%), Gaps = 9/99 (9%) Query: 78 IKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYM 137 +E ++ L + K A+V E +N Q++ + Sbjct: 158 AMKEFAYMKALYERKFPVP-----KPIDYNRHAVVMELINGYPLCQIHHVEDPASVYDEA 212 Query: 138 YEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDW 176 E++ L + G++H D N+++D E + +ID+ Sbjct: 213 MELIVKLA---NHGLIHGDFNEFNLILD-ESDHITMIDF 247 >6EF6-A nrPDB Length = 354 Score = 31.9 bits (71), Expect = 0.47, Method: Composition-based stats. Identities = 8/28 (28%), Positives = 18/28 (64%), Gaps = 2/28 (7%) Query: 151 GIMHRDVKPHNVMIDHEH--RKLRLIDW 176 G++H D++ N+++D R + +ID+ Sbjct: 226 GLIHADLRLANLLVDSSTPQRTITVIDF 253 >4BFR-A nrPDB Length = 952 Score = 31.9 bits (71), Expect = 0.50, Method: Composition-based stats. Identities = 9/64 (14%), Positives = 22/64 (34%), Gaps = 11/64 (17%) Query: 114 EHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRL 173 E+ + D + + T + + + + HS N+M+ + + Sbjct: 769 EYNSGDDLDRAIEEFTLSCAGYCVASYVLGIGDRHS----------DNIMVKKTGQLFHI 818 Query: 174 IDWG 177 D+G Sbjct: 819 -DFG 821 >4P4S-A nrPDB Length = 303 Score = 30.7 bits (68), Expect = 1.3, Method: Composition-based stats. Identities = 12/55 (21%), Positives = 27/55 (49%), Gaps = 12/55 (21%) Query: 313 LTAREAME--------HPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVP 359 L+ EA++ HPYF ++++ G +++P + ++S + S+P Sbjct: 233 LSLSEALQREKIFFENHPYFRDLLEE----GKATVPSLAEKLTSELITHISKSLP 283 >4P4S-B nrPDB Length = 346 Score = 30.3 bits (67), Expect = 1.4, Method: Composition-based stats. Identities = 12/55 (21%), Positives = 27/55 (49%), Gaps = 12/55 (21%) Query: 313 LTAREAME--------HPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVP 359 L+ EA++ HPYF ++++ G +++P + ++S + S+P Sbjct: 248 LSLSEALQREKIFFENHPYFRDLLEE----GKATVPSLAEKLTSELITHISKSLP 298 >6DFL-A nrPDB Length = 259 Score = 30.3 bits (67), Expect = 1.4, Method: Composition-based stats. Identities = 26/198 (13%), Positives = 62/198 (31%), Gaps = 39/198 (19%) Query: 33 WGNQDDYQLVRKLGRGKYSEVFE-------AINITNNEKVVVKILK-------------- 71 W +D ++ V L +V+ + VKI + Sbjct: 13 WNGRDPFEAVEAL----QGKVYRELEGRRTLRTEVDGRGYFVKIHRGIGWGEIAKNLLTA 68 Query: 72 PVKKKKIKREIKILENLRGGPNI-----ITLADIVKDPVSRTPALVFEHVNNT-DFKQLY 125 + ++E + + L + + + DP + +V E + T D + Sbjct: 69 KLPVLGARQEWQAIRRL-HEAGVATMTAVAYGERGSDPARQHSFIVTEELAPTVDLEVFS 127 Query: 126 QTLTDYD-----IRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE 180 Q + R + + + + H G+ HRD + ++ H + + D+ L+ Sbjct: 128 QDWRERPPPPRLKRALVEAVARMVGDMHRAGVNHRDCYICHFLL-HTDKPVSADDFRLS- 185 Query: 181 FYHPGQEYNVRVASRYFK 198 + + ++ Sbjct: 186 VIDLHRAQTRDATPKRWR 203 >2Y0O-A nrPDB Length = 175 Score = 30.3 bits (67), Expect = 1.5, Method: Composition-based stats. Identities = 13/47 (27%), Positives = 25/47 (53%) Query: 158 KPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLV 204 K V+ D E +++L+D+GL + G + V V + + EL++ Sbjct: 14 KAGIVLTDEEVDQIQLMDYGLGKERKVGLQLFVYVNTDRYCSKELVL 60 >4H05-A nrPDB Length = 273 Score = 30.0 bits (66), Expect = 1.7, Method: Composition-based stats. Identities = 10/27 (37%), Positives = 16/27 (59%), Gaps = 1/27 (3%) Query: 152 IMHRDVKPHNVMIDHEHRKLR-LIDWG 177 + H D+ P NV++D ++ LID G Sbjct: 186 VCHGDLCPDNVLLDPRTCEVTGLIDVG 212 >4ESA-B nrPDB Length = 146 Score = 30.0 bits (66), Expect = 2.0, Method: Composition-based stats. Identities = 20/69 (28%), Positives = 29/69 (42%), Gaps = 14/69 (20%) Query: 48 GKYSEVFEAINITNNEKVV---VKIL--------KPVKKKKIKREIKIL--ENLRGGP-N 93 G + ++ A I N+KV +K+L K+I E+ IL E L P N Sbjct: 43 GSFGNLYNAEAIIGNQKVAAHGIKVLHGLDRAVKNMDNIKEIYAELSILHSEKLHVDPDN 102 Query: 94 IITLADIVK 102 LAD + Sbjct: 103 FKLLADCLT 111 >5H12-A nrPDB Length = 775 Score = 29.6 bits (65), Expect = 2.2, Method: Composition-based stats. Identities = 14/32 (43%), Positives = 19/32 (59%) Query: 51 SEVFEAINITNNEKVVVKILKPVKKKKIKREI 82 ++V EAI N + VKI+K V +K K EI Sbjct: 625 AKVLEAILKHGNVEEAVKIVKEVTEKLSKYEI 656 >3VYS-B nrPDB Length = 372 Score = 29.6 bits (65), Expect = 2.3, Method: Composition-based stats. Identities = 7/40 (17%), Positives = 21/40 (52%), Gaps = 2/40 (5%) Query: 63 EKVVVKILKPVKKKK--IKREIKILENLRGGPNIITLADI 100 +V +K+++ ++++ + EI+I+ + +T I Sbjct: 11 REVAMKLVEKIREEAKTLDGEIRIMHVCGTHEDTVTRHGI 50 >4W6Q-A nrPDB Length = 333 Score = 29.6 bits (65), Expect = 2.6, Method: Composition-based stats. Identities = 17/51 (33%), Positives = 23/51 (45%), Gaps = 7/51 (13%) Query: 4 PVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVF 54 +P+ VYTD N P VV+ Q D QL+ K+ G Y V+ Sbjct: 189 RIPTELHVYTDHNMQLPTT-------VVKEPYQSDEQLIMKMSEGGYGLVW 232 >2P8J-A nrPDB Length = 209 Score = 29.2 bits (64), Expect = 3.4, Method: Composition-based stats. Identities = 11/59 (18%), Positives = 24/59 (40%), Gaps = 9/59 (15%) Query: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNII 95 + Y K+G G++ + + EKV I V ++ + K ++ L ++ Sbjct: 134 ERYNKGEKIGEGEF------LQLERGEKV---IHSYVSLEEADKYFKDMKVLFKEDRVV 183 >2GB3-A nrPDB Length = 409 Score = 29.2 bits (64), Expect = 3.5, Method: Composition-based stats. Identities = 11/32 (34%), Positives = 17/32 (53%), Gaps = 2/32 (6%) Query: 156 DVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE 187 DVKP NV++ + + L + A +PG E Sbjct: 99 DVKPENVLVTNGGSEAIL--FSFAVIANPGDE 128 >1CJA-A nrPDB Length = 342 Score = 28.8 bits (63), Expect = 3.9, Method: Composition-based stats. Identities = 15/84 (17%), Positives = 33/84 (39%), Gaps = 11/84 (13%) Query: 234 HGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKR----------WER 283 GH++ Q I ++ YD + +I + F + + W+ Sbjct: 258 PGHESS-QFHSIRDIITLYTGYDVGTEGSISMQEGFLATVRECASFDLDAFERELLSWQE 316 Query: 284 FVHSENQHLVSPEALDFLDKLLRY 307 + + +SP+A+ F+ ++LR Sbjct: 317 SLQKCHNLSISPQAIPFILRMLRI 340 >4FLV-A nrPDB Length = 793 Score = 28.8 bits (63), Expect = 4.1, Method: Composition-based stats. Identities = 14/32 (43%), Positives = 18/32 (56%) Query: 51 SEVFEAINITNNEKVVVKILKPVKKKKIKREI 82 ++V EAI N VKI+K V +K K EI Sbjct: 646 AKVLEAILKHGNVDEAVKIVKEVTEKLSKYEI 677 >6GL3-A nrPDB Length = 386 Score = 28.4 bits (62), Expect = 4.8, Method: Composition-based stats. Identities = 5/19 (26%), Positives = 11/19 (57%), Gaps = 1/19 (5%) Query: 160 HNVMIDHEHRKLRLIDWGL 178 N+++D E + + D+G Sbjct: 263 GNILLDAEGHIIHI-DFGF 280 >3TSR-E nrPDB Length = 457 Score = 28.4 bits (62), Expect = 4.9, Method: Composition-based stats. Identities = 13/56 (23%), Positives = 26/56 (46%), Gaps = 1/56 (1%) Query: 77 KIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNT-DFKQLYQTLTDY 131 + RE+ + N GGP ++ L + +K P LV + T + ++ + L + Sbjct: 394 RSLRELDLSNNCMGGPGVLQLLESLKQPSCTLQQLVLYDIYWTNEVEEQLRALEEE 449 >5C4G-E nrPDB Length = 529 Score = 28.4 bits (62), Expect = 5.2, Method: Composition-based stats. Identities = 5/19 (26%), Positives = 11/19 (57%), Gaps = 1/19 (5%) Query: 160 HNVMIDHEHRKLRLIDWGL 178 N+++D E + + D+G Sbjct: 405 GNILLDAEGHIIHI-DFGF 422 >4D0L-A nrPDB Length = 566 Score = 28.4 bits (62), Expect = 5.2, Method: Composition-based stats. Identities = 5/19 (26%), Positives = 11/19 (57%), Gaps = 1/19 (5%) Query: 160 HNVMIDHEHRKLRLIDWGL 178 N+++D E + + D+G Sbjct: 442 GNILLDAEGHIIHI-DFGF 459 >6HXI-B nrPDB Length = 631 Score = 28.4 bits (62), Expect = 5.3, Method: Composition-based stats. Identities = 14/78 (17%), Positives = 25/78 (32%), Gaps = 1/78 (1%) Query: 227 FRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVH 286 +E + G D L R + G L + K E F +++ + Sbjct: 363 SGEELLYAGKKLSDVLDRKMGIGGVIGLL-WFKKELPEYAAHFIELVIQIVADHGPAVSG 421 Query: 287 SENQHLVSPEALDFLDKL 304 + N + S D + L Sbjct: 422 AHNAIVASCAGKDLISSL 439 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.308 0.140 0.423 Lambda K H 0.267 0.0431 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 16,975,025 Number of Sequences: 36641 Number of extensions: 762673 Number of successful extensions: 6607 Number of sequences better than 10.0: 517 Number of HSP's better than 10.0 without gapping: 819 Number of HSP's successfully gapped in prelim test: 157 Number of HSP's that attempted gapping in prelim test: 2320 Number of HSP's gapped (non-prelim): 1390 length of query: 391 length of database: 10,336,785 effective HSP length: 99 effective length of query: 292 effective length of database: 6,709,326 effective search space: 1959123192 effective search space used: 1959123192 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.1 bits) S2: 60 (27.6 bits)