BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P63245 (317 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 6G51-g nrPDB 653 0.0 4V6W-Ag nrPDB 515 e-146 3DM0-A nrPDB 436 e-123 4V8M-A7 nrPDB 351 2e-97 5OPT-p nrPDB 350 3e-97 6HHQ-h nrPDB 347 4e-96 3JAP-g nrPDB 343 5e-95 4BTS-AR nrPDB 279 1e-75 5XYI-g nrPDB 218 3e-57 1VYH-C nrPDB 127 5e-30 5M25-A nrPDB 118 3e-27 2H9P-A nrPDB 112 2e-25 6HQA-B nrPDB 104 4e-23 6MZM-G nrPDB 102 2e-22 6F3T-A nrPDB 102 3e-22 5NNZ-B nrPDB 98 4e-21 5MZH-A nrPDB 96 2e-20 6QX9-5O nrPDB 96 2e-20 5UZ7-B nrPDB 94 6e-20 6Q8F-A nrPDB 93 2e-19 5FL8-q nrPDB 90 1e-18 6QX9-4B nrPDB 82 2e-16 6ID0-T nrPDB 82 4e-16 5NZU-C nrPDB 81 6e-16 5Y88-O nrPDB 80 8e-16 4V7E-Bg nrPDB 79 2e-15 5K1B-B nrPDB 79 4e-15 4J0W-A nrPDB 77 8e-15 5WYJ-BC nrPDB 77 1e-14 6EMK-B nrPDB 75 3e-14 5FVM-C nrPDB 75 5e-14 4LG8-A nrPDB 73 1e-13 5Z56-q nrPDB 73 2e-13 2YNP-A nrPDB 71 6e-13 3MKQ-A nrPDB 71 8e-13 5GAN-H nrPDB 71 8e-13 5I2T-A nrPDB 70 1e-12 5WLC-LO nrPDB 70 1e-12 3CFV-B nrPDB 69 2e-12 6GMH-W nrPDB 69 2e-12 6EOJ-D nrPDB 69 3e-12 3JB9-g nrPDB 67 7e-12 6N9G-C nrPDB 66 2e-11 6QDV-o nrPDB 66 2e-11 5OQL-J nrPDB 66 2e-11 5YZG-W nrPDB 66 3e-11 1NR0-A nrPDB 65 4e-11 5WYK-BB nrPDB 64 8e-11 5MWJ-A nrPDB 63 2e-10 3C9C-A nrPDB 61 6e-10 3JB9-L nrPDB 60 2e-09 3ODT-A nrPDB 59 3e-09 5Y1U-A nrPDB 59 3e-09 4N14-A nrPDB 59 3e-09 4GGA-A nrPDB 59 3e-09 5LCW-Q nrPDB 59 4e-09 5L9T-R nrPDB 58 5e-09 5G04-R nrPDB 58 5e-09 6BX3-A nrPDB 58 5e-09 5WBU-D nrPDB 56 2e-08 4AEZ-A nrPDB 55 3e-08 4L9O-A nrPDB 55 4e-08 6J6H-n nrPDB 55 6e-08 5WJC-A nrPDB 54 7e-08 3FM0-A nrPDB 54 1e-07 5OQL-L nrPDB 53 1e-07 3ACP-A nrPDB 52 2e-07 5OQL-d nrPDB 51 8e-07 5BJS-A nrPDB 50 9e-07 5K19-A nrPDB 49 2e-06 5FA5-B nrPDB 49 3e-06 4YCZ-A nrPDB 49 3e-06 4OWR-A nrPDB 49 3e-06 6ELZ-p nrPDB 49 4e-06 6CHG-A nrPDB 48 5e-06 2HES-X nrPDB 48 5e-06 5WLC-LJ nrPDB 48 7e-06 5WYJ-BE nrPDB 47 7e-06 4PSX-B nrPDB 47 8e-06 5OQL-X nrPDB 47 1e-05 4BH6-A nrPDB 47 1e-05 5M89-A nrPDB 47 2e-05 5A31-R nrPDB 47 2e-05 4A11-B nrPDB 46 2e-05 4J0X-A nrPDB 46 2e-05 4U1E-I nrPDB 46 2e-05 5WLC-LU nrPDB 46 2e-05 3BG0-A nrPDB 46 3e-05 5WLC-SG nrPDB 45 3e-05 5CXB-B nrPDB 45 4e-05 5K0Y-T nrPDB 45 4e-05 4BZK-B nrPDB 44 7e-05 4XYI-A nrPDB 44 7e-05 6E29-D nrPDB 44 7e-05 3JRP-A nrPDB 44 8e-05 4G56-B nrPDB 43 2e-04 2AQ5-A nrPDB 43 2e-04 3JB9-S nrPDB 43 2e-04 3JRO-A nrPDB 43 2e-04 3JZG-A nrPDB 40 0.001 2PM9-A nrPDB 40 0.002 5WLC-LN nrPDB 40 0.002 5LTD-A nrPDB 40 0.002 5OV3-A nrPDB 38 0.005 3W15-A nrPDB 37 0.012 5CXC-A nrPDB 36 0.021 5TF2-A nrPDB 36 0.022 5N4A-A nrPDB 36 0.026 4XFV-A nrPDB 36 0.028 6BX3-B nrPDB 35 0.029 6CB1-s nrPDB 35 0.032 6C0F-s nrPDB 35 0.040 1H78-A nrPDB 35 0.042 6EM1-m nrPDB 35 0.045 5WLC-LS nrPDB 34 0.067 6CHG-D nrPDB 34 0.095 3F3P-A nrPDB 34 0.10 5WLC-LH nrPDB 33 0.14 1PI6-A nrPDB 33 0.16 2VDU-B nrPDB 32 0.24 5A9Q-7 nrPDB 32 0.27 5MC6-j nrPDB 32 0.53 3DW8-B nrPDB 31 0.63 6F1U-h nrPDB 31 0.64 3AMK-A nrPDB 31 0.65 2IO8-A nrPDB 31 0.67 5YZG-2 nrPDB 31 0.73 4E5Z-B nrPDB 31 0.78 1GFF-1 nrPDB 31 0.78 4AYX-A nrPDB 30 1.0 3I2N-A nrPDB 30 1.6 5WT2-A nrPDB 29 2.5 5WLC-LW nrPDB 28 6.1 5A9Q-0 nrPDB 27 8.9 >6G51-g nrPDB Length = 317 Score = 653 bits (1685), Expect = 0.0, Method: Compositional matrix adjust. Identities = 317/317 (100%), Positives = 317/317 (100%) Query: 1 MTEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALR 60 MTEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALR Sbjct: 1 MTEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALR 60 Query: 61 GHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQI 120 GHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQI Sbjct: 61 GHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQI 120 Query: 121 VSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLA 180 VSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLA Sbjct: 121 VSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLA 180 Query: 181 NCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALC 240 NCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALC Sbjct: 181 NCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALC 240 Query: 241 FSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFA 300 FSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFA Sbjct: 241 FSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFA 300 Query: 301 GYTDNLVRVWQVTIGTR 317 GYTDNLVRVWQVTIGTR Sbjct: 301 GYTDNLVRVWQVTIGTR 317 >4V6W-Ag nrPDB Length = 318 Score = 515 bits (1326), Expect = e-146, Method: Compositional matrix adjust. Identities = 243/315 (77%), Positives = 275/315 (87%), Gaps = 1/315 (0%) Query: 1 MTEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDE-TNYGIPQRAL 59 M+E + LRGTL GHNGWVTQIAT P+ PD I+SASRDKT+I+WKLTRDE TNYG PQ+ L Sbjct: 1 MSETLQLRGTLIGHNGWVTQIATNPKDPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRL 60 Query: 60 RGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQ 119 GHSHF+SDVV+SSDG +ALSGSWD TLRLWDL G TTRRF GHTKDVLSVAFS+DNRQ Sbjct: 61 YGHSHFISDVVLSSDGNYALSGSWDQTLRLWDLAAGKTTRRFEGHTKDVLSVAFSADNRQ 120 Query: 120 IVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNL 179 IVSGSRDKTIKLWNTL CK+T+Q++ H++WVSCVRFSPN SNPIIVSCGWD+ VKVWNL Sbjct: 121 IVSGSRDKTIKLWNTLAECKFTIQEDGHTDWVSCVRFSPNHSNPIIVSCGWDRTVKVWNL 180 Query: 180 ANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINAL 239 ANCKLK NH GH GYLNTVTVSPDGSLC SGGKD +A+LWDLN+GK+LYTL+ DIINAL Sbjct: 181 ANCKLKNNHHGHNGYLNTVTVSPDGSLCTSGGKDSKALLWDLNDGKNLYTLEHNDIINAL 240 Query: 240 CFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLF 299 CFSPNRYWLC A GPSIKIWDL K V+EL+ EV+S +SKA+ PQC SLAWS DGQTLF Sbjct: 241 CFSPNRYWLCVAYGPSIKIWDLACKKTVEELRPEVVSPTSKADQPQCLSLAWSTDGQTLF 300 Query: 300 AGYTDNLVRVWQVTI 314 AGY+DN +RVWQV++ Sbjct: 301 AGYSDNTIRVWQVSV 315 >3DM0-A nrPDB Length = 694 Score = 436 bits (1120), Expect = e-123, Method: Compositional matrix adjust. Identities = 210/320 (65%), Positives = 249/320 (77%), Gaps = 12/320 (3%) Query: 5 MTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSH 64 + L+GT++ H VT IAT D+I+SASRDK+II+WKLT+D+ YG+ QR L GHSH Sbjct: 372 LVLKGTMRAHTDMVTAIATPIDNADIIVSASRDKSIILWKLTKDDKAYGVAQRRLTGHSH 431 Query: 65 FVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGS 124 FV DVV+SSDGQFALSGSWDG LRLWDL G +TRRFVGHTKDVLSVAFS DNRQIVS S Sbjct: 432 FVEDVVLSSDGQFALSGSWDGELRLWDLAAGVSTRRFVGHTKDVLSVAFSLDNRQIVSAS 491 Query: 125 RDKTIKLWNTLGVCKYTVQD--ESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANC 182 RD+TIKLWNTLG CKYT+ + E H +WVSCVRFSPN+ P IVS WDK VKVWNL+NC Sbjct: 492 RDRTIKLWNTLGECKYTISEGGEGHRDWVSCVRFSPNTLQPTIVSASWDKTVKVWNLSNC 551 Query: 183 KLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFS 242 KL++ GHTGY++TV VSPDGSLCASGGKDG +LWDL EGK LY+L+ +I+ALCFS Sbjct: 552 KLRSTLAGHTGYVSTVAVSPDGSLCASGGKDGVVLLWDLAEGKKLYSLEANSVIHALCFS 611 Query: 243 PNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAE---PPQ-------CTSLAWS 292 PNRYWLCAAT IKIWDLE K IV++LK ++ + + KA+ P CTSL WS Sbjct: 612 PNRYWLCAATEHGIKIWDLESKSIVEDLKVDLKAEAEKADNSGPAATKRKVIYCTSLNWS 671 Query: 293 ADGQTLFAGYTDNLVRVWQV 312 ADG TLF+GYTD ++RVW + Sbjct: 672 ADGSTLFSGYTDGVIRVWGI 691 Score = 58.9 bits (141), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 66/231 (28%), Positives = 99/231 (42%), Gaps = 31/231 (13%) Query: 103 GHTKDVLSVAFSSDNRQI-VSGSRDKTIKLWN------TLGVCKYTVQDESHSEWVSCVR 155 HT V ++A DN I VS SRDK+I LW GV + + HS +V V Sbjct: 380 AHTDMVTAIATPIDNADIIVSASRDKSIILWKLTKDDKAYGVAQRRLT--GHSHFVEDVV 437 Query: 156 FSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQ 215 S S +S WD +++W+LA +GHT + +V S D S +D Sbjct: 438 LS--SDGQFALSGSWDGELRLWDLAAGVSTRRFVGHTKDVLSVAFSLDNRQIVSASRDRT 495 Query: 216 AMLWD-LNEGKHLYTLDGG-----DIINALCFSPNRYW---LCAATGPSIKIWDLEGKII 266 LW+ L E K YT+ G D ++ + FSPN + A+ ++K+W+L + Sbjct: 496 IKLWNTLGECK--YTISEGGEGHRDWVSCVRFSPNTLQPTIVSASWDKTVKVWNLSNCKL 553 Query: 267 VDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGTR 317 L S+ A P DG +G D +V +W + G + Sbjct: 554 RSTLAGHTGYVSTVAVSP---------DGSLCASGGKDGVVLLWDLAEGKK 595 >4V8M-A7 nrPDB Length = 318 Score = 351 bits (901), Expect = 2e-97, Method: Compositional matrix adjust. Identities = 174/315 (55%), Positives = 221/315 (70%), Gaps = 8/315 (2%) Query: 5 MTLRGTLKGHNGWVTQIA--TTPQFPDMILSASRDKTIIMWKLTRD----ETNYGIPQRA 58 + G L GH GWVT +A TP+ ++S SRDKT++ W D E +YG+P R Sbjct: 3 VAYEGQLTGHRGWVTSLACPQTPETATKVVSTSRDKTLLSWGPNPDRHSSECSYGLPDRR 62 Query: 59 LRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNR 118 L GHS FVSDV +S++G FA+S SWD +LRLW+L G +F+GHTKDVLSVAFS DNR Sbjct: 63 LEGHSAFVSDVALSNNGNFAVSASWDHSLRLWNLQNGQCQYKFLGHTKDVLSVAFSPDNR 122 Query: 119 QIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWN 178 QIVSG RD +++WN G C +T+ +H++WVSCVRFSP+ P+IVS GWD LVKVW+ Sbjct: 123 QIVSGGRDNALRVWNVKGECMHTLSRGAHTDWVSCVRFSPSLDAPVIVSGGWDNLVKVWD 182 Query: 179 LANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINA 238 LA +L T+ GHT Y+ +VTVSPDGSLCAS KDG A LWDL +G+ L + G IN Sbjct: 183 LATGRLVTDLKGHTNYVTSVTVSPDGSLCASSDKDGVARLWDLTKGEALSEMAAGAPINQ 242 Query: 239 LCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTL 298 +CFSPNRYW+CAAT I+I+DLE K I+ EL E SK P+C S+AWSADG TL Sbjct: 243 ICFSPNRYWMCAATEKGIRIFDLENKDIIVELAPE--HQGSKKIVPECVSIAWSADGSTL 300 Query: 299 FAGYTDNLVRVWQVT 313 ++GYTDN++RVW V+ Sbjct: 301 YSGYTDNVIRVWGVS 315 Score = 79.7 bits (195), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 65/211 (30%), Positives = 101/211 (47%), Gaps = 26/211 (12%) Query: 119 QIVSGSRDKTIKLWNT-----LGVCKYTVQD---ESHSEWVSCVRFSPNSSNPIIVSCGW 170 ++VS SRDKT+ W C Y + D E HS +VS V S N + VS W Sbjct: 30 KVVSTSRDKTLLSWGPNPDRHSSECSYGLPDRRLEGHSAFVSDVALSNNGN--FAVSASW 87 Query: 171 DKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTL 230 D +++WNL N + + +GHT + +V SPD SGG+D +W++ +G+ ++TL Sbjct: 88 DHSLRLWNLQNGQCQYKFLGHTKDVLSVAFSPDNRQIVSGGRDNALRVWNV-KGECMHTL 146 Query: 231 DGG---DIINALCFSPNRYWLCAATG---PSIKIWDLEGKIIVDELKQEVISTSSKAEPP 284 G D ++ + FSP+ +G +K+WDL +V +LK Sbjct: 147 SRGAHTDWVSCVRFSPSLDAPVIVSGGWDNLVKVWDLATGRLVTDLK---------GHTN 197 Query: 285 QCTSLAWSADGQTLFAGYTDNLVRVWQVTIG 315 TS+ S DG + D + R+W +T G Sbjct: 198 YVTSVTVSPDGSLCASSDKDGVARLWDLTKG 228 >5OPT-p nrPDB Length = 318 Score = 350 bits (899), Expect = 3e-97, Method: Compositional matrix adjust. Identities = 173/316 (54%), Positives = 220/316 (69%), Gaps = 10/316 (3%) Query: 5 MTLRGTLKGHNGWVTQIATTPQFPDMILSA---SRDKTIIMWKLTRD----ETNYGIPQR 57 + G LKGH GWVT +A PQ + + A SRD T+I W D E YG P+R Sbjct: 3 VVYEGQLKGHRGWVTALAC-PQITETYIKAVSTSRDNTLIAWGSNMDRNSEECEYGFPER 61 Query: 58 ALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDN 117 L GHS FVSDV +S++G FA+S SWD +LRLW+L TG +F+GHTKDVLSV FS DN Sbjct: 62 RLEGHSAFVSDVALSNNGDFAVSASWDHSLRLWNLQTGVCQHKFLGHTKDVLSVTFSPDN 121 Query: 118 RQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVW 177 RQIVSG RD +++WN G C +T+ +H++WVSCVRFSP+ P+IVS GWD LVKVW Sbjct: 122 RQIVSGGRDNALRVWNVKGECLHTLGRGAHTDWVSCVRFSPSLETPLIVSGGWDNLVKVW 181 Query: 178 NLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIIN 237 ++A+ +L T+ GHT Y+ +VTVSPDGSLCAS KDG A LWDL +G+ L + G IN Sbjct: 182 DIASGRLLTDLKGHTNYITSVTVSPDGSLCASSDKDGVARLWDLTKGEALSEMAAGAPIN 241 Query: 238 ALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQT 297 +CFSPNRYW+CAAT I+I+DLE K ++ EL E S K P+C S+AWSADG T Sbjct: 242 QICFSPNRYWMCAATEKGIRIFDLENKDVIVELAPEAQQKSKKT--PECMSIAWSADGNT 299 Query: 298 LFAGYTDNLVRVWQVT 313 L++GYTDN++RVW V+ Sbjct: 300 LYSGYTDNVIRVWSVS 315 Score = 72.0 bits (175), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 62/211 (29%), Positives = 98/211 (46%), Gaps = 26/211 (12%) Query: 119 QIVSGSRDKTIKLWNT-----LGVCKYTVQD---ESHSEWVSCVRFSPNSSNPIIVSCGW 170 + VS SRD T+ W + C+Y + E HS +VS V S N VS W Sbjct: 30 KAVSTSRDNTLIAWGSNMDRNSEECEYGFPERRLEGHSAFVSDVALSNNGD--FAVSASW 87 Query: 171 DKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTL 230 D +++WNL + +GHT + +VT SPD SGG+D +W++ +G+ L+TL Sbjct: 88 DHSLRLWNLQTGVCQHKFLGHTKDVLSVTFSPDNRQIVSGGRDNALRVWNV-KGECLHTL 146 Query: 231 DGG---DIINALCFSPNRYWLCAATG---PSIKIWDLEGKIIVDELKQEVISTSSKAEPP 284 G D ++ + FSP+ +G +K+WD+ ++ +LK Sbjct: 147 GRGAHTDWVSCVRFSPSLETPLIVSGGWDNLVKVWDIASGRLLTDLK---------GHTN 197 Query: 285 QCTSLAWSADGQTLFAGYTDNLVRVWQVTIG 315 TS+ S DG + D + R+W +T G Sbjct: 198 YITSVTVSPDGSLCASSDKDGVARLWDLTKG 228 >6HHQ-h nrPDB Length = 319 Score = 347 bits (890), Expect = 4e-96, Method: Compositional matrix adjust. Identities = 169/314 (53%), Positives = 219/314 (69%), Gaps = 7/314 (2%) Query: 3 EQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGH 62 E + LRGTL+GHNGWVT +AT+ P+++LSASRDKT+I WKLT D+ +G+P R+ +GH Sbjct: 5 EVLVLRGTLEGHNGWVTSLATSAGQPNLLLSASRDKTLISWKLTGDDQKFGVPVRSFKGH 64 Query: 63 SHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVS 122 SH V D +++DG +ALS SWD TLRLWD+ TG T +RFVGH DV+SV I+S Sbjct: 65 SHIVQDCTLTADGAYALSASWDKTLRLWDVATGETYQRFVGHKSDVMSVDIDKKASMIIS 124 Query: 123 GSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSS----NPIIVSCGWDKLVKVWN 178 GSRDKTIK+W G C T+ H++WVS VR PN + I+S G DK+VK WN Sbjct: 125 GSRDKTIKVWTIKGQCLATLL--GHNDWVSQVRVVPNEKADDDSVTIISAGNDKMVKAWN 182 Query: 179 LANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINA 238 L +++ + IGH +NT+T SPDG+L AS GKDG+ MLW+L K +YTL D + + Sbjct: 183 LNQFQIEADFIGHNSNINTLTASPDGTLIASAGKDGEIMLWNLAAKKAMYTLSAQDEVFS 242 Query: 239 LCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTL 298 L FSPNRYWL AAT IK++ L+ + +VD+L+ E + SKA P SLAWSADGQTL Sbjct: 243 LAFSPNRYWLAAATATGIKVFSLDPQYLVDDLRPE-FAGYSKAAEPHAVSLAWSADGQTL 301 Query: 299 FAGYTDNLVRVWQV 312 FAGYTDN++RVWQV Sbjct: 302 FAGYTDNVIRVWQV 315 Score = 42.4 bits (98), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 40/180 (22%), Positives = 66/180 (36%), Gaps = 58/180 (32%) Query: 9 GTLKGHNGWVTQIATTPQFPD-----MILSASRDKTIIMWKLTRDETNYGIPQRALRGHS 63 TL GHN WV+Q+ P I+SA DK + W L + + + GH+ Sbjct: 142 ATLLGHNDWVSQVRVVPNEKADDDSVTIISAGNDKMVKAWNLNQFQI-----EADFIGHN 196 Query: 64 HFVSDVVISSDGQFALSGSWDGTLRLWDLT-----------------------------T 94 ++ + S DG S DG + LW+L T Sbjct: 197 SNINTLTASPDGTLIASAGKDGEIMLWNLAAKKAMYTLSAQDEVFSLAFSPNRYWLAAAT 256 Query: 95 GTTTR---------------RFVGHTK----DVLSVAFSSDNRQIVSGSRDKTIKLWNTL 135 T + F G++K +S+A+S+D + + +G D I++W + Sbjct: 257 ATGIKVFSLDPQYLVDDLRPEFAGYSKAAEPHAVSLAWSADGQTLFAGYTDNVIRVWQVM 316 >3JAP-g nrPDB Length = 326 Score = 343 bits (880), Expect = 5e-95, Method: Compositional matrix adjust. Identities = 163/318 (51%), Positives = 223/318 (70%), Gaps = 13/318 (4%) Query: 5 MTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSH 64 + LRGTL+GHNGWVT ++T+ P++++S SRDKT+I W+LT +E +G+P R+ +GHSH Sbjct: 8 LVLRGTLEGHNGWVTSLSTSAAQPNLLVSGSRDKTLISWRLTENEQQFGVPVRSYKGHSH 67 Query: 65 FVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGS 124 V DVV+S+DG +A+S SWD TLRLW+L TG + RFVGHT DVLSVA +++ +I+S S Sbjct: 68 IVQDVVVSADGNYAVSASWDKTLRLWNLATGNSEARFVGHTGDVLSVAIDANSSKIISAS 127 Query: 125 RDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSP--------NSSNPIIVSCGWDKLVKV 176 RDKTI++WNT+G C Y + H++WV+ VR +P + VS G DK+V+ Sbjct: 128 RDKTIRVWNTVGDCAYVLL--GHTDWVTKVRVAPKNLEDGEVDDGRITFVSAGMDKIVRS 185 Query: 177 WNLA--NCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGD 234 W+L + +++ + IGH Y+N V SPDGSL AS GKDGQ +W+L D D Sbjct: 186 WSLNEDSYRIEADFIGHNNYINVVQPSPDGSLAASAGKDGQIYVWNLKHKSAFMNFDAKD 245 Query: 235 IINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSAD 294 + AL FSP+R+WL AAT IKI+DLE ++++DELK E + +KA+ P SLAWSAD Sbjct: 246 EVFALAFSPSRFWLTAATASGIKIYDLENEVLIDELKPE-FAGYTKAQDPHAVSLAWSAD 304 Query: 295 GQTLFAGYTDNLVRVWQV 312 GQTLFAGYTDN++RVWQV Sbjct: 305 GQTLFAGYTDNVIRVWQV 322 Score = 42.0 bits (97), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 42/182 (23%), Positives = 70/182 (38%), Gaps = 60/182 (32%) Query: 11 LKGHNGWVTQIATTPQFPD---------MILSASRDKTIIMWKLTRDETNYGIPQRALRG 61 L GH WVT++ P+ + +SA DK + W L D +Y I + G Sbjct: 145 LLGHTDWVTKVRVAPKNLEDGEVDDGRITFVSAGMDKIVRSWSLNED--SYRIEADFI-G 201 Query: 62 HSHFVSDVVISSDGQFALSGSWDGTLRLWDL---------------------------TT 94 H+++++ V S DG A S DG + +W+L T Sbjct: 202 HNNYINVVQPSPDGSLAASAGKDGQIYVWNLKHKSAFMNFDAKDEVFALAFSPSRFWLTA 261 Query: 95 GTTT-----------------RRFVGHTK----DVLSVAFSSDNRQIVSGSRDKTIKLWN 133 T + F G+TK +S+A+S+D + + +G D I++W Sbjct: 262 ATASGIKIYDLENEVLIDELKPEFAGYTKAQDPHAVSLAWSADGQTLFAGYTDNVIRVWQ 321 Query: 134 TL 135 + Sbjct: 322 VM 323 >4BTS-AR nrPDB Length = 343 Score = 279 bits (713), Expect = 1e-75, Method: Compositional matrix adjust. Identities = 147/328 (44%), Positives = 208/328 (63%), Gaps = 22/328 (6%) Query: 4 QMTLRGTLKGHNGWVTQIAT-----TPQFPDMILSASRDKTIIMWKLTRDETN--YGIPQ 56 Q+ RG L+GH+ WVT I + +++S SRDKT+++WKL +E N +GIP Sbjct: 10 QVVKRGILEGHSDWVTSIVAGFSQKENEDSPVLISGSRDKTVMIWKLYEEEQNGYFGIPH 69 Query: 57 RALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSD 116 +AL GH+HFVSD+ +S + FA+S SWD TLRLWDL TGTT +RFVGH +V SVAFS D Sbjct: 70 KALTGHNHFVSDLALSQENCFAISSSWDKTLRLWDLRTGTTYKRFVGHQSEVYSVAFSPD 129 Query: 117 NRQIVSGSRDKTIKLWNTLGVCKY-TVQDESHSEWVSCVRFSP--NSSN------PIIVS 167 NRQI+S ++ IKLWN LG CK+ + + E+HS+WVSCVR+SP S+N P S Sbjct: 130 NRQILSAGAEREIKLWNILGECKFSSAEKENHSDWVSCVRYSPIMKSANKVQPFAPYFAS 189 Query: 168 CGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWD-LNEGKH 226 GWD +KVWN N +++ H +N +++SP+G A+GGKD + ++WD LN Sbjct: 190 VGWDGRLKVWN-TNFQIRYTFKAHESNVNHLSISPNGKYIATGGKDKKLLIWDILNLTYP 248 Query: 227 LYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDL--EGKIIVDELKQEVISTSS--KAE 282 D G IN + F+P W+ T +KI++L + K V ++ E I+ + K + Sbjct: 249 QREFDAGSTINQIAFNPKLQWVAVGTDQGVKIFNLMTQSKAPVCTIEAEPITKAEGQKGK 308 Query: 283 PPQCTSLAWSADGQTLFAGYTDNLVRVW 310 PQCTSLAW+A G+ LFAG+TD ++R + Sbjct: 309 NPQCTSLAWNALGKKLFAGFTDGVIRTF 336 >5XYI-g nrPDB Length = 335 Score = 218 bits (555), Expect = 3e-57, Method: Compositional matrix adjust. Identities = 117/311 (37%), Positives = 173/311 (55%), Gaps = 10/311 (3%) Query: 8 RGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVS 67 R T GHN + I + + ++SASRDK+ ++WKL R + + P L GH+HFVS Sbjct: 26 RATFVGHNAAIESIEIDNEH-NYLVSASRDKSALVWKLNRTQEQWATPFTRLIGHNHFVS 84 Query: 68 DVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDK 127 DV +S D L+ SWD TLRLWDL+T TT + F+GH KDVL V FS NR+I+S RD Sbjct: 85 DVSLSRDASHLLTSSWDSTLRLWDLSTRTTKKLFLGHKKDVLGVTFSPCNRRIISVGRDN 144 Query: 128 TIKLWNTLGVCKYTVQDESHSEWVSCVRFSP--NSSNPIIVSCG-WDKLVKVWNLA-NCK 183 +K+WN LG K +Q S WV+ V +P + ++P++++ G WD V +W++ K Sbjct: 145 QVKIWNILGENKAELQ---CSSWVTSVACAPMADETSPLVIAVGCWDGKVYIWSIEKEAK 201 Query: 184 LKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSP 243 L H G +V +PDG +GG D + ++W G + ++A+ P Sbjct: 202 LIKEFKAHDGRCTSVDFTPDGKWVITGGSDRKVVMWLTENGAKTISFTAPSPVHAVAACP 261 Query: 244 NRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSK--AEPPQCTSLAWSADGQTLFAG 301 + W+CAAT I +WD+ K +D ++ + P CT LAW+ADG L++G Sbjct: 262 TQAWICAATYEGIAVWDIGAKQQIDLVQPNFKHEGKRNAGRTPDCTCLAWAADGSVLYSG 321 Query: 302 YTDNLVRVWQV 312 Y D +R W+V Sbjct: 322 YNDGSIRAWEV 332 Score = 67.8 bits (164), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 57/230 (24%), Positives = 110/230 (47%), Gaps = 27/230 (11%) Query: 101 FVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDE---------SHSEWV 151 FVGH + S+ +++ +VS SRDK+ +W Q++ H+ +V Sbjct: 29 FVGHNAAIESIEIDNEHNYLVSASRDKSALVWKL-----NRTQEQWATPFTRLIGHNHFV 83 Query: 152 SCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGG 211 S V S ++S+ +++ WD +++W+L+ K +GH + VT SP S G Sbjct: 84 SDVSLSRDASH--LLTSSWDSTLRLWDLSTRTTKKLFLGHKKDVLGVTFSPCNRRIISVG 141 Query: 212 KDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATGP---SIKIWDLEGKIIVD 268 +D Q +W++ G++ L + ++ +P + T P ++ WD GK+ + Sbjct: 142 RDNQVKIWNI-LGENKAELQCSSWVTSVACAP----MADETSPLVIAVGCWD--GKVYIW 194 Query: 269 ELKQEV-ISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGTR 317 +++E + KA +CTS+ ++ DG+ + G +D V +W G + Sbjct: 195 SIEKEAKLIKEFKAHDGRCTSVDFTPDGKWVITGGSDRKVVMWLTENGAK 244 >1VYH-C nrPDB Length = 410 Score = 127 bits (320), Expect = 5e-30, Method: Compositional matrix adjust. Identities = 98/324 (30%), Positives = 141/324 (43%), Gaps = 42/324 (12%) Query: 11 LKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVV 70 L GH VT++ P F M+ SAS D TI +W + G +R L+GH+ V D+ Sbjct: 104 LSGHRSPVTRVIFHPVFSVMV-SASEDATIKVW-----DYETGDFERTLKGHTDSVQDIS 157 Query: 71 ISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIK 130 G+ S S D T++LWD R GH +V SV+ + IVS SRDKTIK Sbjct: 158 FDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVSIMPNGDHIVSASRDKTIK 217 Query: 131 LWNT-LGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHI 189 +W G C T H EWV VR PN +I SC D+ V+VW +A + K Sbjct: 218 MWEVQTGYCVKTFT--GHREWVRMVR--PNQDGTLIASCSNDQTVRVWVVATKECKAELR 273 Query: 190 GHTGYLNTVTVSPD--------------------GSLCASGGKDGQAMLWDLNEGKHLYT 229 H + ++ +P+ G SG +D +WD++ G L T Sbjct: 274 EHRHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMT 333 Query: 230 LDGGD--IINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCT 287 L G D + L S ++ L A ++++WD + K + L A T Sbjct: 334 LVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTL---------NAHEHFVT 384 Query: 288 SLAWSADGQTLFAGYTDNLVRVWQ 311 SL + + G D V+VW+ Sbjct: 385 SLDFHKTAPYVVTGSVDQTVKVWE 408 >5M25-A nrPDB Length = 434 Score = 118 bits (296), Expect = 3e-27, Method: Compositional matrix adjust. Identities = 98/312 (31%), Positives = 156/312 (50%), Gaps = 26/312 (8%) Query: 14 HNGWVTQIATTPQFPDM----ILSASRDK---TIIMWKLTRDETNYGIPQRALRGHSHFV 66 ++G Q TP+ DM I+ A R++ + K T + NY + + L GH+ V Sbjct: 90 YDGIRIQADQTPEDLDMEDNDIIEAHREQIGGSATQSKPTPVKPNYAL-KFTLAGHTKAV 148 Query: 67 SDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRD 126 S V S +G++ S S D +++W G + GH + VA+SSD+ +VS S D Sbjct: 149 SSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDD 208 Query: 127 KTIKLWN-TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLK 185 KT+K+W+ + G C T++ HS +V C F+P S+ +IVS +D+ V++W++ K Sbjct: 209 KTLKIWDVSSGKCLKTLK--GHSNYVFCCNFNPQSN--LIVSGSFDESVRIWDVKTGKCL 264 Query: 186 TNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTL--DGGDIINALCFSP 243 H+ ++ V + DGSL S DG +WD G+ L TL D ++ + FSP Sbjct: 265 KTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSP 324 Query: 244 N-RYWLCAATGPSIKIWDL-EGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQT-LFA 300 N +Y L A ++K+WD +GK + T K E C +S G + + Sbjct: 325 NGKYILAATLDNTLKLWDYSKGKCLK-------TYTGHKNEK-YCIFANFSVTGGKWIVS 376 Query: 301 GYTDNLVRVWQV 312 G DNLV +W + Sbjct: 377 GSEDNLVYIWNL 388 Score = 107 bits (267), Expect = 7e-24, Method: Compositional matrix adjust. Identities = 86/282 (30%), Positives = 141/282 (50%), Gaps = 20/282 (7%) Query: 7 LRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFV 66 L+ TL GH V+ + +P + + S+S DK I +W G ++ + GH + Sbjct: 137 LKFTLAGHTKAVSSVKFSPN-GEWLASSSADKLIKIWGAYD-----GKFEKTISGHKLGI 190 Query: 67 SDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRD 126 SDV SSD +S S D TL++WD+++G + GH+ V F+ + IVSGS D Sbjct: 191 SDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFD 250 Query: 127 KTIKLWNT-LGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCK-L 184 +++++W+ G C T+ +HS+ VS V F N +IVS +D L ++W+ A+ + L Sbjct: 251 ESVRIWDVKTGKCLKTL--PAHSDPVSAVHF--NRDGSLIVSSSYDGLCRIWDTASGQCL 306 Query: 185 KTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGD-----IINAL 239 KT ++ V SP+G + D LWD ++GK L T G I Sbjct: 307 KTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANF 366 Query: 240 CFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQE---VISTS 278 + ++ + + + IW+L+ K IV +L+ VIST+ Sbjct: 367 SVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTA 408 Score = 81.6 bits (200), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 63/214 (29%), Positives = 101/214 (47%), Gaps = 11/214 (5%) Query: 10 TLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDV 69 TLKGH+ +V PQ ++I+S S D+++ +W + G + L HS VS V Sbjct: 224 TLKGHSNYVFCCNFNPQ-SNLIVSGSFDESVRIW-----DVKTGKCLKTLPAHSDPVSAV 277 Query: 70 VISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLS-VAFSSDNRQIVSGSRDKT 128 + DG +S S+DG R+WD +G + + +S V FS + + I++ + D T Sbjct: 278 HFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNT 337 Query: 129 IKLWN-TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTN 187 +KLW+ + G C T + ++ FS + IVS D LV +WNL ++ Sbjct: 338 LKLWDYSKGKCLKTYTGHKNEKYCIFANFSV-TGGKWIVSGSEDNLVYIWNLQTKEIVQK 396 Query: 188 HIGHTGYLNTVTVSPDGSLCASGG--KDGQAMLW 219 GHT + + P ++ AS D LW Sbjct: 397 LQGHTDVVISTACHPTENIIASAALENDKTIKLW 430 Score = 43.9 bits (102), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 32/109 (29%), Positives = 54/109 (49%), Gaps = 10/109 (9%) Query: 31 ILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVIS---SDGQFALSGSWDGTL 87 IL+A+ D T+ +W ++ G + GH + + + + G++ +SGS D + Sbjct: 329 ILAATLDNTLKLWDYSK-----GKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLV 383 Query: 88 RLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGS--RDKTIKLWNT 134 +W+L T ++ GHT V+S A I S + DKTIKLW + Sbjct: 384 YIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKS 432 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 37/137 (27%), Positives = 58/137 (42%), Gaps = 11/137 (8%) Query: 181 NCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDI-INAL 239 N LK GHT +++V SP+G AS D +W +GK T+ G + I+ + Sbjct: 134 NYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDV 193 Query: 240 CFSPNRYWLCAAT-GPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTL 298 +S + L +A+ ++KIWD+ + LK PQ + Sbjct: 194 AWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQ---------SNLI 244 Query: 299 FAGYTDNLVRVWQVTIG 315 +G D VR+W V G Sbjct: 245 VSGSFDESVRIWDVKTG 261 >2H9P-A nrPDB Length = 329 Score = 112 bits (281), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 89/275 (32%), Positives = 141/275 (51%), Gaps = 19/275 (6%) Query: 44 KLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVG 103 K T + NY + + L GH+ VS V S +G++ S S D +++W G + G Sbjct: 22 KPTPVKPNYAL-KFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISG 80 Query: 104 HTKDVLSVAFSSDNRQIVSGSRDKTIKLWN-TLGVCKYTVQDESHSEWVSCVRFSPNSSN 162 H + VA+SSD+ +VS S DKT+K+W+ + G C T++ HS +V C F+P S+ Sbjct: 81 HKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLK--GHSNYVFCCNFNPQSN- 137 Query: 163 PIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLN 222 +IVS +D+ V++W++ K H+ ++ V + DGSL S DG +WD Sbjct: 138 -LIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTA 196 Query: 223 EGKHLYTL--DGGDIINALCFSPN-RYWLCAATGPSIKIWDL-EGKIIVDELKQEVISTS 278 G+ L TL D ++ + FSPN +Y L A ++K+WD +GK + T Sbjct: 197 SGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLK-------TYTG 249 Query: 279 SKAEPPQCTSLAWSADG-QTLFAGYTDNLVRVWQV 312 K E C +S G + + +G DNLV +W + Sbjct: 250 HKNEK-YCIFANFSVTGGKWIVSGSEDNLVYIWNL 283 Score = 107 bits (267), Expect = 7e-24, Method: Compositional matrix adjust. Identities = 86/285 (30%), Positives = 141/285 (49%), Gaps = 20/285 (7%) Query: 4 QMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHS 63 L+ TL GH V+ + +P + + S+S DK I +W G ++ + GH Sbjct: 29 NYALKFTLAGHTKAVSSVKFSPN-GEWLASSSADKLIKIWGAYD-----GKFEKTISGHK 82 Query: 64 HFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSG 123 +SDV SSD +S S D TL++WD+++G + GH+ V F+ + IVSG Sbjct: 83 LGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSG 142 Query: 124 SRDKTIKLWNT-LGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANC 182 S D+++++W+ G C T+ +HS+ VS V F N +IVS +D L ++W+ A+ Sbjct: 143 SFDESVRIWDVKTGKCLKTL--PAHSDPVSAVHF--NRDGSLIVSSSYDGLCRIWDTASG 198 Query: 183 K-LKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGD-----II 236 + LKT ++ V SP+G + D LWD ++GK L T G I Sbjct: 199 QCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIF 258 Query: 237 NALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQE---VISTS 278 + ++ + + + IW+L+ K IV +L+ VIST+ Sbjct: 259 ANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTA 303 Score = 81.3 bits (199), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 63/214 (29%), Positives = 101/214 (47%), Gaps = 11/214 (5%) Query: 10 TLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDV 69 TLKGH+ +V PQ ++I+S S D+++ +W + G + L HS VS V Sbjct: 119 TLKGHSNYVFCCNFNPQ-SNLIVSGSFDESVRIW-----DVKTGKCLKTLPAHSDPVSAV 172 Query: 70 VISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLS-VAFSSDNRQIVSGSRDKT 128 + DG +S S+DG R+WD +G + + +S V FS + + I++ + D T Sbjct: 173 HFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNT 232 Query: 129 IKLWN-TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTN 187 +KLW+ + G C T + ++ FS + IVS D LV +WNL ++ Sbjct: 233 LKLWDYSKGKCLKTYTGHKNEKYCIFANFSV-TGGKWIVSGSEDNLVYIWNLQTKEIVQK 291 Query: 188 HIGHTGYLNTVTVSPDGSLCASGG--KDGQAMLW 219 GHT + + P ++ AS D LW Sbjct: 292 LQGHTDVVISTACHPTENIIASAALENDKTIKLW 325 Score = 44.7 bits (104), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 36/133 (27%), Positives = 63/133 (47%), Gaps = 11/133 (8%) Query: 7 LRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFV 66 L+ + N V+ + +P IL+A+ D T+ +W ++ G + GH + Sbjct: 201 LKTLIDDDNPPVSFVKFSPN-GKYILAATLDNTLKLWDYSK-----GKCLKTYTGHKNEK 254 Query: 67 SDVVIS---SDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSG 123 + + + G++ +SGS D + +W+L T ++ GHT V+S A I S Sbjct: 255 YCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASA 314 Query: 124 S--RDKTIKLWNT 134 + DKTIKLW + Sbjct: 315 ALENDKTIKLWKS 327 Score = 41.2 bits (95), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 37/137 (27%), Positives = 58/137 (42%), Gaps = 11/137 (8%) Query: 181 NCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDI-INAL 239 N LK GHT +++V SP+G AS D +W +GK T+ G + I+ + Sbjct: 29 NYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDV 88 Query: 240 CFSPNRYWLCAAT-GPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTL 298 +S + L +A+ ++KIWD+ + LK PQ + Sbjct: 89 AWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQ---------SNLI 139 Query: 299 FAGYTDNLVRVWQVTIG 315 +G D VR+W V G Sbjct: 140 VSGSFDESVRIWDVKTG 156 >6HQA-B nrPDB Length = 722 Score = 104 bits (260), Expect = 4e-23, Method: Compositional matrix adjust. Identities = 74/231 (32%), Positives = 114/231 (49%), Gaps = 17/231 (7%) Query: 57 RALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSD 116 R L GHS V V S D ++ +S S D T+RLW L T T + GH+ V V FS Sbjct: 447 RRLVGHSGAVYGVDFSPDNRYLISCSEDKTVRLWSLDTYTCLVSYKGHSSSVWDVKFSPM 506 Query: 117 NRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKV 176 + S D+T +LW+ + + H V CV F PNS+ + + DK ++ Sbjct: 507 GHYFATASHDQTARLWSCDHIYPLRIF-AGHLNDVDCVEFHPNST--YLFTGSSDKTARM 563 Query: 177 WNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTL--DGGD 234 W++A + +GH+G +N + VSPDG AS G+D LWD++ G+ + + G Sbjct: 564 WDIARGECVRVFMGHSGAINCLAVSPDGRWLASAGEDSVVCLWDISTGRRIKAMRGHGRS 623 Query: 235 IINALCFSPNRYWLCAATGP--SIKIWDLEGKIIVDELKQEVISTSSKAEP 283 I +L FS + +TG S+++WD +K+ S S++ EP Sbjct: 624 SIYSLAFS-REGTVLVSTGADNSVRVWD---------VKKNTNSPSAQPEP 664 Score = 89.0 bits (219), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 67/221 (30%), Positives = 103/221 (46%), Gaps = 13/221 (5%) Query: 98 TRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFS 157 +RR VGH+ V V FS DNR ++S S DKT++LW +L V + HS V V+FS Sbjct: 446 SRRLVGHSGAVYGVDFSPDNRYLISCSEDKTVRLW-SLDTYTCLVSYKGHSSSVWDVKFS 504 Query: 158 PNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAM 217 P + D+ ++W+ + GH ++ V P+ + +G D A Sbjct: 505 PMGH--YFATASHDQTARLWSCDHIYPLRIFAGHLNDVDCVEFHPNSTYLFTGSSDKTAR 562 Query: 218 LWDLNEGKHLYTLDG-GDIINALCFSPNRYWLCAATGPSIK-IWDLEGKIIVDELKQEVI 275 +WD+ G+ + G IN L SP+ WL +A S+ +WD+ + ++ Sbjct: 563 MWDIARGECVRVFMGHSGAINCLAVSPDGRWLASAGEDSVVCLWDISTGRRIKAMRGHGR 622 Query: 276 STSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGT 316 S+ SLA+S +G L + DN VRVW V T Sbjct: 623 SS--------IYSLAFSREGTVLVSTGADNSVRVWDVKKNT 655 Score = 65.9 bits (159), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 66/243 (27%), Positives = 104/243 (42%), Gaps = 41/243 (16%) Query: 101 FVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVC--------KYTVQDES------ 146 F D+ + F+ D+ + SG +D IKLW+ G Y Q+ Sbjct: 386 FHNTNNDLTCLKFNDDSTMVASGFQDSFIKLWSIDGSPLRSLLKNDPYNQQNNDGVAVKG 445 Query: 147 ------HSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTV 200 HS V V FSP+ N ++SC DK V++W+L ++ GH+ + V Sbjct: 446 SRRLVGHSGAVYGVDFSPD--NRYLISCSEDKTVRLWSLDTYTCLVSYKGHSSSVWDVKF 503 Query: 201 SPDGSLCASGGKDGQAMLWDLNEGKHLYTLD--GGDIINALC--FSPNR-YWLCAATGPS 255 SP G A+ D A LW + H+Y L G + + C F PN Y ++ + Sbjct: 504 SPMGHYFATASHDQTARLWSCD---HIYPLRIFAGHLNDVDCVEFHPNSTYLFTGSSDKT 560 Query: 256 IKIWDL-EGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTI 314 ++WD+ G+ + V S A LA S DG+ L + D++V +W ++ Sbjct: 561 ARMWDIARGECV------RVFMGHSGA----INCLAVSPDGRWLASAGEDSVVCLWDIST 610 Query: 315 GTR 317 G R Sbjct: 611 GRR 613 >6MZM-G nrPDB Length = 800 Score = 102 bits (254), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 67/206 (32%), Positives = 102/206 (49%), Gaps = 5/206 (2%) Query: 57 RALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSD 116 + L GHS V S D + LS S DGT+RLW L T T + GH V FS Sbjct: 537 KILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPY 596 Query: 117 NRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKV 176 VSG D+ +LW T + H V+C RF PNS+ + + D+ V++ Sbjct: 597 GYYFVSGGHDRVARLWATDHYQPLRIF-AGHLADVNCTRFHPNSN--YVATGSADRTVRL 653 Query: 177 WNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGG-DI 235 W++ N GH G ++++T SP+G A+G DG+ +LWD+ G + L G D Sbjct: 654 WDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDT 713 Query: 236 INALCFSPNRYWLCAAT-GPSIKIWD 260 + +L FS + L + + ++++WD Sbjct: 714 VCSLRFSRDGEILASGSMDNTVRLWD 739 Score = 84.3 bits (207), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 63/210 (30%), Positives = 98/210 (46%), Gaps = 14/210 (6%) Query: 103 GHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSN 162 GH+ V +FS D ++S S D T++LW +L V + H+ V +FSP Sbjct: 541 GHSGPVYGASFSPDRNYLLSSSEDGTVRLW-SLQTFTCLVGYKGHNYPVWDTQFSPYGY- 598 Query: 163 PIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLN 222 VS G D++ ++W + + GH +N P+ + A+G D LWD+ Sbjct: 599 -YFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVL 657 Query: 223 EGKHLYTLDGGD-IINALCFSPN-RYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSK 280 G + G I++L FSPN R+ AT + +WD+ ++V ELK + Sbjct: 658 NGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDT---- 713 Query: 281 AEPPQCTSLAWSADGQTLFAGYTDNLVRVW 310 SL +S DG+ L +G DN VR+W Sbjct: 714 -----VCSLRFSRDGEILASGSMDNTVRLW 738 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 48/169 (28%), Positives = 80/169 (47%), Gaps = 13/169 (7%) Query: 12 KGHNG--WVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDV 69 KGHN W TQ + + +S D+ +W T++ P R GH V+ Sbjct: 582 KGHNYPVWDTQFSPYGYY---FVSGGHDRVARLWA-----TDHYQPLRIFAGHLADVNCT 633 Query: 70 VISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTI 129 + + +GS D T+RLWD+ G R F GH + S+ FS + R + +G+ D + Sbjct: 634 RFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRV 693 Query: 130 KLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWN 178 LW+ +G + + H++ V +RFS + I+ S D V++W+ Sbjct: 694 LLWD-IGHGLMVGELKGHTDTVCSLRFSRDGE--ILASGSMDNTVRLWD 739 Score = 62.4 bits (150), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 33/107 (30%), Positives = 54/107 (50%), Gaps = 5/107 (4%) Query: 29 DMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLR 88 + + + S D+T+ +W + G R GH + + S +G+F +G+ DG + Sbjct: 640 NYVATGSADRTVRLWDVLN-----GNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVL 694 Query: 89 LWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTL 135 LWD+ G GHT V S+ FS D + SGS D T++LW+ + Sbjct: 695 LWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAI 741 Score = 47.8 bits (112), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 47/172 (27%), Positives = 72/172 (41%), Gaps = 15/172 (8%) Query: 147 HSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSL 206 HS V FSP+ + ++S D V++W+L + GH + SP G Sbjct: 542 HSGPVYGASFSPDRN--YLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYY 599 Query: 207 CASGGKDGQAMLWDLNEGKHLYTLDGGDI-INALCFSPNRYWLCAATGP-SIKIWD-LEG 263 SGG D A LW + + L G +N F PN ++ + ++++WD L G Sbjct: 600 FVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNG 659 Query: 264 KIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIG 315 + I T K SL +S +G+ L G TD V +W + G Sbjct: 660 NCVR-------IFTGHKGP---IHSLTFSPNGRFLATGATDGRVLLWDIGHG 701 >6F3T-A nrPDB Length = 608 Score = 102 bits (253), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 67/206 (32%), Positives = 102/206 (49%), Gaps = 5/206 (2%) Query: 57 RALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSD 116 + L GHS V S D + LS S DGT+RLW L T T + GH V FS Sbjct: 345 KILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPY 404 Query: 117 NRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKV 176 VSG D+ +LW T + H V+C RF PNS+ + + D+ V++ Sbjct: 405 GYYFVSGGHDRVARLWATDHYQPLRIF-AGHLADVNCTRFHPNSN--YVATGSADRTVRL 461 Query: 177 WNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGG-DI 235 W++ N GH G ++++T SP+G A+G DG+ +LWD+ G + L G D Sbjct: 462 WDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDT 521 Query: 236 INALCFSPNRYWLCAAT-GPSIKIWD 260 + +L FS + L + + ++++WD Sbjct: 522 VCSLRFSRDGEILASGSMDNTVRLWD 547 Score = 89.0 bits (219), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 66/225 (29%), Positives = 104/225 (46%), Gaps = 14/225 (6%) Query: 88 RLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESH 147 R+ D T + + GH+ V +FS D ++S S D T++LW +L V + H Sbjct: 334 RIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLW-SLQTFTCLVGYKGH 392 Query: 148 SEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLC 207 + V +FSP VS G D++ ++W + + GH +N P+ + Sbjct: 393 NYPVWDTQFSPYGY--YFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYV 450 Query: 208 ASGGKDGQAMLWDLNEGKHLYTLDGGD-IINALCFSPN-RYWLCAATGPSIKIWDLEGKI 265 A+G D LWD+ G + G I++L FSPN R+ AT + +WD+ + Sbjct: 451 ATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGL 510 Query: 266 IVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVW 310 +V ELK + SL +S DG+ L +G DN VR+W Sbjct: 511 MVGELKGHTDT---------VCSLRFSRDGEILASGSMDNTVRLW 546 Score = 68.2 bits (165), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 48/169 (28%), Positives = 80/169 (47%), Gaps = 13/169 (7%) Query: 12 KGHNG--WVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDV 69 KGHN W TQ + + +S D+ +W T++ P R GH V+ Sbjct: 390 KGHNYPVWDTQFSPYGYY---FVSGGHDRVARLWA-----TDHYQPLRIFAGHLADVNCT 441 Query: 70 VISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTI 129 + + +GS D T+RLWD+ G R F GH + S+ FS + R + +G+ D + Sbjct: 442 RFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRV 501 Query: 130 KLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWN 178 LW+ +G + + H++ V +RFS + I+ S D V++W+ Sbjct: 502 LLWD-IGHGLMVGELKGHTDTVCSLRFSRDGE--ILASGSMDNTVRLWD 547 Score = 62.0 bits (149), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 33/107 (30%), Positives = 54/107 (50%), Gaps = 5/107 (4%) Query: 29 DMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLR 88 + + + S D+T+ +W + G R GH + + S +G+F +G+ DG + Sbjct: 448 NYVATGSADRTVRLWDVLN-----GNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVL 502 Query: 89 LWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTL 135 LWD+ G GHT V S+ FS D + SGS D T++LW+ + Sbjct: 503 LWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAI 549 Score = 52.8 bits (125), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 63/250 (25%), Positives = 100/250 (40%), Gaps = 27/250 (10%) Query: 69 VVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKT 128 V ++ D G D T+R+W +T K + SV +SD I S D Sbjct: 284 VDVTDDSSLIAGGFADSTVRVWSVTP-----------KKLRSVKQASDLSLIDKESDDVL 332 Query: 129 IKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNH 188 ++ + + + HS V FSP+ + ++S D V++W+L + Sbjct: 333 ERIMDEKTASELKIL-YGHSGPVYGASFSPDRN--YLLSSSEDGTVRLWSLQTFTCLVGY 389 Query: 189 IGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDI-INALCFSPNRYW 247 GH + SP G SGG D A LW + + L G +N F PN + Sbjct: 390 KGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNY 449 Query: 248 LCAATGP-SIKIWD-LEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDN 305 + + ++++WD L G + I T K SL +S +G+ L G TD Sbjct: 450 VATGSADRTVRLWDVLNGNCVR-------IFTGHKGP---IHSLTFSPNGRFLATGATDG 499 Query: 306 LVRVWQVTIG 315 V +W + G Sbjct: 500 RVLLWDIGHG 509 >5NNZ-B nrPDB Length = 415 Score = 98.2 bits (243), Expect = 4e-21, Method: Compositional matrix adjust. Identities = 63/224 (28%), Positives = 108/224 (48%), Gaps = 11/224 (4%) Query: 10 TLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDV 69 T +GH + ++ PQ ++ + S D T +W + E Y LRGHS + + Sbjct: 172 TFRGHTAEIVCLSFNPQ-STLVATGSMDTTAKLWDIQNGEEVY-----TLRGHSAEIISL 225 Query: 70 VISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTI 129 ++ G ++GS+D T+ +WD TG +GH ++ S +F+ D I++GS DKT Sbjct: 226 SFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTC 285 Query: 130 KLWN-TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNH 188 KLW+ T G C T+ SC + + +I + D ++++ A K Sbjct: 286 KLWDATNGKCVATLTGHDDEILDSCFDY----TGKLIATASADGTARIFSAATRKCIAKL 341 Query: 189 IGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG 232 GH G ++ ++ +P G+ +G D A +WD G+ L L+G Sbjct: 342 EGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEG 385 Score = 96.3 bits (238), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 77/304 (25%), Positives = 136/304 (44%), Gaps = 19/304 (6%) Query: 10 TLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDV 69 TL+GH V IA + D I + S DKT +W + ET G RGH+ + + Sbjct: 129 TLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSV---ET--GKCYHTFRGHTAEIVCL 183 Query: 70 VISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTI 129 + +GS D T +LWD+ G GH+ +++S++F++ +I++GS D T+ Sbjct: 184 SFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTV 243 Query: 130 KLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHI 189 +W+ K + H +S F+ + S +I++ DK K+W+ N K Sbjct: 244 VVWDADTGRKVNILI-GHCAEISSASFNWDCS--LILTGSMDKTCKLWDATNGKCVATLT 300 Query: 190 GHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGD-IINALCFSPN-RYW 247 GH + G L A+ DG A ++ K + L+G + I+ + F+P + Sbjct: 301 GHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHL 360 Query: 248 LCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLV 307 L ++ + +IWD + + L + + S A++ G + G DN Sbjct: 361 LTGSSDKTARIWDAQTGQCLQVL---------EGHTDEIFSCAFNYKGNIVITGSKDNTC 411 Query: 308 RVWQ 311 R+W+ Sbjct: 412 RIWR 415 Score = 91.7 bits (226), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 80/313 (25%), Positives = 135/313 (43%), Gaps = 23/313 (7%) Query: 7 LRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFV 66 L LK H +T +A ++ S D+T +W +T G L GH + V Sbjct: 84 LFKVLKAHILPLTNVALNKS-GSCFITGSYDRTCKLW-----DTASGEELNTLEGHRNVV 137 Query: 67 SDVVISSD-GQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSR 125 + ++ G +GS+D T +LW + TG F GHT +++ ++F+ + + +GS Sbjct: 138 YAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSM 197 Query: 126 DKTIKLWNTL-GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKL 184 D T KLW+ G YT++ S + S N+S I++ +D V VW+ + Sbjct: 198 DTTAKLWDIQNGEEVYTLRGHS----AEIISLSFNTSGDRIITGSFDHTVVVWDADTGRK 253 Query: 185 KTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGD--IINALCFS 242 IGH +++ + + D SL +G D LWD GK + TL G D I+++ CF Sbjct: 254 VNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDS-CFD 312 Query: 243 PNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGY 302 TG I +G + + + + ++++ G L G Sbjct: 313 --------YTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGS 364 Query: 303 TDNLVRVWQVTIG 315 +D R+W G Sbjct: 365 SDKTARIWDAQTG 377 >5MZH-A nrPDB Length = 452 Score = 96.3 bits (238), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 79/306 (25%), Positives = 137/306 (44%), Gaps = 21/306 (6%) Query: 10 TLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDV 69 TL+GH V IA + D I++ S DKT +W + Y L+GH + + Sbjct: 131 TLEGHKNVVYAIAFNNPYGDKIVTGSFDKTCKLWDAYTGQLYY-----TLKGHQTEIVCL 185 Query: 70 VISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTI 129 + +GS D T +LWD+ TG GH +++S+ F++ IV+GS D Sbjct: 186 SFNPQSTIIATGSMDNTAKLWDVETGQERATLAGHRAEIVSLGFNTGGDLIVTGSFDHDS 245 Query: 130 KLWNT-LGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNH 188 +LW+ G C + + H VS +F N + ++VS D ++W++ + + + Sbjct: 246 RLWDVRTGQCVHVL--SGHRGEVSSTQF--NYAGTLVVSGSIDCTSRLWDVRSGRCLSVK 301 Query: 189 IGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGD-IINALCFSPNRYW 247 GHT + V G+ S DG A L+ G +TL G + I+ + F+P Sbjct: 302 QGHTDEVLDVAFDAAGTKMVSASADGSARLYHTLTGVCQHTLVGHEGEISKVAFNPQGTR 361 Query: 248 LC-AATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNL 306 L A++ + ++WD + + L + + S A++ +G + G DN Sbjct: 362 LITASSDKTCRLWDCDTGECLQVL---------EGHTDEIFSCAFNYEGDFIITGSKDNT 412 Query: 307 VRVWQV 312 R+W+ Sbjct: 413 CRIWKA 418 Score = 85.9 bits (211), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 64/213 (30%), Positives = 99/213 (46%), Gaps = 11/213 (5%) Query: 8 RGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVS 67 R TL GH + + D+I++ S D +W + G L GH VS Sbjct: 214 RATLAGHRAEIVSLGFNTG-GDLIVTGSFDHDSRLW-----DVRTGQCVHVLSGHRGEVS 267 Query: 68 DVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDK 127 + G +SGS D T RLWD+ +G GHT +VL VAF + ++VS S D Sbjct: 268 STQFNYAGTLVVSGSIDCTSRLWDVRSGRCLSVKQGHTDEVLDVAFDAAGTKMVSASADG 327 Query: 128 TIKLWNTL-GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKT 186 + +L++TL GVC++T+ H +S V F+P + I S DK ++W+ + Sbjct: 328 SARLYHTLTGVCQHTLV--GHEGEISKVAFNPQGTRLITASS--DKTCRLWDCDTGECLQ 383 Query: 187 NHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLW 219 GHT + + + +G +G KD +W Sbjct: 384 VLEGHTDEIFSCAFNYEGDFIITGSKDNTCRIW 416 Score = 82.4 bits (202), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 51/178 (28%), Positives = 91/178 (51%), Gaps = 6/178 (3%) Query: 57 RALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSD 116 + LR H +++ + G ++GS+D T ++W+ TG GH V ++AF++ Sbjct: 88 KVLRAHILPLTNCAFNKSGDRFITGSYDRTCKVWNTFTGEEVFTLEGHKNVVYAIAFNNP 147 Query: 117 -NRQIVSGSRDKTIKLWNTL-GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLV 174 +IV+GS DKT KLW+ G YT++ H + C+ F+P S+ II + D Sbjct: 148 YGDKIVTGSFDKTCKLWDAYTGQLYYTLK--GHQTEIVCLSFNPQST--IIATGSMDNTA 203 Query: 175 KVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG 232 K+W++ + + GH + ++ + G L +G D + LWD+ G+ ++ L G Sbjct: 204 KLWDVETGQERATLAGHRAEIVSLGFNTGGDLIVTGSFDHDSRLWDVRTGQCVHVLSG 261 Score = 73.9 bits (180), Expect = 8e-14, Method: Compositional matrix adjust. Identities = 75/321 (23%), Positives = 131/321 (40%), Gaps = 23/321 (7%) Query: 1 MTEQ----MTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQ 56 M EQ TL L+ H +T A D ++ S D+T +W E + Sbjct: 76 MLEQQHHSFTLFKVLRAHILPLTNCAFNKS-GDRFITGSYDRTCKVWNTFTGEEVF---- 130 Query: 57 RALRGHSHFVSDVVISSD-GQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSS 115 L GH + V + ++ G ++GS+D T +LWD TG GH +++ ++F+ Sbjct: 131 -TLEGHKNVVYAIAFNNPYGDKIVTGSFDKTCKLWDAYTGQLYYTLKGHQTEIVCLSFNP 189 Query: 116 DNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVK 175 + I +GS D T KLW+ + +E VS N+ +IV+ +D + Sbjct: 190 QSTIIATGSMDNTAKLWDVETGQERATLAGHRAEIVS---LGFNTGGDLIVTGSFDHDSR 246 Query: 176 VWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGG-D 234 +W++ + GH G +++ + G+L SG D + LWD+ G+ L G D Sbjct: 247 LWDVRTGQCVHVLSGHRGEVSSTQFNYAGTLVVSGSIDCTSRLWDVRSGRCLSVKQGHTD 306 Query: 235 IINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSAD 294 + + F A G + +G + V + + + +A++ Sbjct: 307 EVLDVAFD--------AAGTKMVSASADGSARLYHTLTGVCQHTLVGHEGEISKVAFNPQ 358 Query: 295 GQTLFAGYTDNLVRVWQVTIG 315 G L +D R+W G Sbjct: 359 GTRLITASSDKTCRLWDCDTG 379 Score = 65.1 bits (157), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 40/124 (32%), Positives = 61/124 (49%), Gaps = 6/124 (4%) Query: 12 KGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVI 71 +GH V +A M+ SAS D + ++ T G+ Q L GH +S V Sbjct: 302 QGHTDEVLDVAFDAAGTKMV-SASADGSARLY-----HTLTGVCQHTLVGHEGEISKVAF 355 Query: 72 SSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKL 131 + G ++ S D T RLWD TG + GHT ++ S AF+ + I++GS+D T ++ Sbjct: 356 NPQGTRLITASSDKTCRLWDCDTGECLQVLEGHTDEIFSCAFNYEGDFIITGSKDNTCRI 415 Query: 132 WNTL 135 W L Sbjct: 416 WKAL 419 Score = 48.5 bits (114), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 28/88 (31%), Positives = 47/88 (53%), Gaps = 6/88 (6%) Query: 10 TLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDV 69 TL GH G ++++A PQ +I +AS DKT +W + + G + L GH+ + Sbjct: 342 TLVGHEGEISKVAFNPQGTRLI-TASSDKTCRLW-----DCDTGECLQVLEGHTDEIFSC 395 Query: 70 VISSDGQFALSGSWDGTLRLWDLTTGTT 97 + +G F ++GS D T R+W T ++ Sbjct: 396 AFNYEGDFIITGSKDNTCRIWKALTASS 423 >6QX9-5O nrPDB Length = 357 Score = 95.9 bits (237), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 79/254 (31%), Positives = 123/254 (48%), Gaps = 20/254 (7%) Query: 9 GTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSD 68 TLKGH+G V ++ M+ SAS DKT+ +W ++ G + L+GH+ FV+ Sbjct: 103 ATLKGHSGAVMELHYNTD-GSMLFSASTDKTVAVW-----DSETGERVKRLKGHTSFVNS 156 Query: 69 VVISSDG-QFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDK 127 + G Q +GS DGT++LWD+ + F +T VL+V F+ + QI+SG D Sbjct: 157 CYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDN 215 Query: 128 TIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTN 187 IK+W+ L K T H++ V+ + S S ++S D V+VW++ K Sbjct: 216 DIKVWD-LRQNKLTYTMRGHADSVTGLSLSSEGS--YLLSNAMDNTVRVWDVRPFAPKER 272 Query: 188 HIG------HTGYLNTVTVS--PDGSLCASGGKDGQAMLWDLNEGKHLYTLDG-GDIINA 238 + H N + S PDGS A+G D +WD + LY L G IN Sbjct: 273 CVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINE 332 Query: 239 LCFSPNRYWLCAAT 252 + F P+ + +A+ Sbjct: 333 VAFHPDEPIIISAS 346 Score = 95.1 bits (235), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 87/304 (28%), Positives = 129/304 (42%), Gaps = 51/304 (16%) Query: 11 LKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVV 70 L GH G V P + SA D+ I++W + D NY L+GHS V ++ Sbjct: 62 LSGHEGEVYCCKFHPN-GSTLASAGFDRLILLWNVYGDCDNYA----TLKGHSGAVMELH 116 Query: 71 ISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIV-SGSRDKTI 129 ++DG S S D T+ +WD TG +R GHT V S + Q+V +GS D T+ Sbjct: 117 YNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTV 176 Query: 130 KLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHI 189 KLW+ K +Q ++ V V F N ++ I+S G D +KVW+L KL Sbjct: 177 KLWDIRK--KAAIQTFQNTYQVLAVTF--NDTSDQIISGGIDNDIKVWDLRQNKLTYTMR 232 Query: 190 GHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLC 249 GH + +++S +GS S D +WD+ F+P Sbjct: 233 GHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRP-----------------FAPKER--- 272 Query: 250 AATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRV 309 +KI+ +G V ++ ++ S WS DG + AG D V V Sbjct: 273 -----CVKIF--QGN--VHNFEKNLLRCS------------WSPDGSKIAAGSADRFVYV 311 Query: 310 WQVT 313 W T Sbjct: 312 WDTT 315 Score = 44.7 bits (104), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 36/136 (26%), Positives = 62/136 (45%), Gaps = 12/136 (8%) Query: 3 EQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALR-- 60 Q L T++GH VT ++ + + +LS + D T+ +W D + +R ++ Sbjct: 223 RQNKLTYTMRGHADSVTGLSLSSE-GSYLLSNAMDNTVRVW----DVRPFAPKERCVKIF 277 Query: 61 -GHSHFVSDVVI----SSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSS 115 G+ H ++ S DG +GS D + +WD T+ + GH + VAF Sbjct: 278 QGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHP 337 Query: 116 DNRQIVSGSRDKTIKL 131 D I+S S DK + + Sbjct: 338 DEPIIISASSDKRLYM 353 >5UZ7-B nrPDB Length = 351 Score = 94.4 bits (233), Expect = 6e-20, Method: Compositional matrix adjust. Identities = 74/267 (27%), Positives = 123/267 (46%), Gaps = 15/267 (5%) Query: 56 QRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSS 115 +R LRGH + + +D + +S S DG L +WD T + V++ A++ Sbjct: 59 RRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAP 118 Query: 116 DNRQIVSGSRDKTIKLWNTL---GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDK 172 + G D ++N G + + + H+ ++SC RF + N I+ S G D Sbjct: 119 SGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDD--NQIVTSSG-DT 175 Query: 173 LVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG 232 +W++ + T GHTG + +++++PD L SG D A LWD+ EG T G Sbjct: 176 TCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTG 235 Query: 233 GDI-INALCFSPN-RYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLA 290 + INA+CF PN + + + +++DL QE+++ S TS++ Sbjct: 236 HESDINAICFFPNGNAFATGSDDATCRLFDLRA-------DQELMTYSHDNIICGITSVS 288 Query: 291 WSADGQTLFAGYTDNLVRVWQVTIGTR 317 +S G+ L AGY D VW R Sbjct: 289 FSKSGRLLLAGYDDFNCNVWDALKADR 315 Score = 74.7 bits (182), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 78/318 (24%), Positives = 133/318 (41%), Gaps = 31/318 (9%) Query: 4 QMTLRGTLKGHNGWVTQIATTPQFPD--MILSASRDKTIIMWKLTRDETNYGIPQRALRG 61 QM R TL+GH + +I D +++SAS+D +I+W + IP R Sbjct: 55 QMRTRRTLRGH---LAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLR---- 107 Query: 62 HSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGT----TTRRFVGHTKDVLSVAFSSDN 117 S +V + G + G D +++L T +R GHT + F DN Sbjct: 108 -SSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDN 166 Query: 118 RQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVW 177 QIV+ S D T LW+ + + T H+ V + +P++ + VS D K+W Sbjct: 167 -QIVTSSGDTTCALWD-IETGQQTTTFTGHTGDVMSLSLAPDTR--LFVSGACDASAKLW 222 Query: 178 NLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDI-- 235 ++ + GH +N + P+G+ A+G D L+DL + L T +I Sbjct: 223 DVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIIC 282 Query: 236 -INALCFSPN-RYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSA 293 I ++ FS + R L + +W D LK + + + + L + Sbjct: 283 GITSVSFSKSGRLLLAGYDDFNCNVW--------DALKADRAGVLA-GHDNRVSCLGVTD 333 Query: 294 DGQTLFAGYTDNLVRVWQ 311 DG + G D+ +++W Sbjct: 334 DGMAVATGSWDSFLKIWN 351 >6Q8F-A nrPDB Length = 514 Score = 92.8 bits (229), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 69/262 (26%), Positives = 122/262 (46%), Gaps = 32/262 (12%) Query: 28 PDMILSASRDKTIIMWKLTRDETNYGIPQRALR----GHSHFVSDVVISSDGQFALSGSW 83 P M + R K + +D P + R G V S DGQ+ ++GS Sbjct: 181 PGMTIDLFRGKAAV-----KDVEEEKFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSV 235 Query: 84 DGTLRLWDLTTGTTTRRFVGHTKD--------VLSVAFSSDNRQIVSGSRDKTIKLWNTL 135 DG + +W+ TTG + +D VL + FS D + +G++D IK+W Sbjct: 236 DGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQ 295 Query: 136 -GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGY 194 G C + +HS+ V+C+ FS +SS I+S +D+ +++ L + K GH+ + Sbjct: 296 SGQCLRRF-ERAHSKGVTCLSFSKDSSQ--ILSASFDQTIRIHGLKSGKTLKEFRGHSSF 352 Query: 195 LNTVTVSPDGSLCASGGKDGQAMLWDL------NEGKHLYTLDGGDI-INALCF---SPN 244 +N T + DG S DG +W++ N K L + G DI +N++ +P Sbjct: 353 VNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPE 412 Query: 245 RYWLCAATGPSIKIWDLEGKII 266 + +C + ++ I +++G+I+ Sbjct: 413 HFVVCNRSN-TVVIMNMQGQIV 433 Score = 57.8 bits (138), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 59/222 (26%), Positives = 96/222 (43%), Gaps = 18/222 (8%) Query: 7 LRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFV 66 LR + H+ VT ++ + ILSAS D+TI + L +T + RGHS FV Sbjct: 300 LRRFERAHSKGVTCLSFSKD-SSQILSASFDQTIRIHGLKSGKT-----LKEFRGHSSFV 353 Query: 67 SDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRF------VGHTKDVLSVAFSSDN-RQ 119 ++ + DG + +S S DGT+++W++ T + F G V SV N Sbjct: 354 NEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEH 413 Query: 120 IVSGSRDKTIKLWNTLG--VCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVW 177 V +R T+ + N G V ++ ++V C SP I G D ++ + Sbjct: 414 FVVCNRSNTVVIMNMQGQIVRSFSSGKREGGDFVCCA-LSPRGE--WIYCVGEDFVLYCF 470 Query: 178 NLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLW 219 + KL+ H + + P +L A+ +DG LW Sbjct: 471 STVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLW 512 Score = 29.3 bits (64), Expect = 2.3, Method: Compositional matrix adjust. Identities = 18/67 (26%), Positives = 26/67 (38%), Gaps = 5/67 (7%) Query: 254 PSIKIWDLEGKIIVDELKQEVISTS-----SKAEPPQCTSLAWSADGQTLFAGYTDNLVR 308 P + I GK V ++++E T + +S DGQ L G D + Sbjct: 181 PGMTIDLFRGKAAVKDVEEEKFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIE 240 Query: 309 VWQVTIG 315 VW T G Sbjct: 241 VWNFTTG 247 >5FL8-q nrPDB Length = 515 Score = 90.1 bits (222), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 90/353 (25%), Positives = 146/353 (41%), Gaps = 72/353 (20%) Query: 10 TLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDV 69 TLKGH WV ++ +P ++I + S D TI +W D + ALRGHS +++ + Sbjct: 181 TLKGHYNWVLCVSWSPDG-EVIATGSMDNTIRLW----DPKSGQCLGDALRGHSKWITSL 235 Query: 70 -------VISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVS 122 V S S DGT+++WD + GHT V V + + S Sbjct: 236 SWEPIHLVKPGSKPRLASSSKDGTIKIWDTVSRVCQYTMSGHTNSVSCVKWGGQG-LLYS 294 Query: 123 GSRDKTIKLW--NTLGVCKYTVQDESHSEWVSCVRFSPN--------------------- 159 GS D+T+++W N+ G C ++ SH+ WV+ + S + Sbjct: 295 GSHDRTVRVWDINSQGRCINILK--SHAHWVNHLSLSTDYALRIGAFDHTGKKPSTPEEA 352 Query: 160 ----------------SSNPIIVSCGWDKLVKVWN-LANCKLKTNHIGHTGYLNTVTVSP 202 +S ++V+ D + +WN L + K GH +N V SP Sbjct: 353 QKKALENYEKICKKNGNSEEMMVTASDDYTMFLWNPLKSTKPIARMTGHQKLVNHVAFSP 412 Query: 203 DGSLCASGGKDGQAMLWDLNEGKHLYTLDG--GDIINALCFSPNRYWLCAATGPSIKIWD 260 DG S D LWD +GK + T G + S R + + ++K+WD Sbjct: 413 DGRYIVSASFDNSIKLWDGRDGKFISTFRGHVASVYQVAWSSDCRLLVSCSKDTTLKVWD 472 Query: 261 LEGKIIVDEL---KQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVW 310 + + + +L K EV ++ WS DG+ + +G D +VR+W Sbjct: 473 VRTRKLSVDLPGHKDEVY------------TVDWSVDGKRVCSGGKDKMVRLW 513 Score = 86.7 bits (213), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 88/354 (24%), Positives = 153/354 (43%), Gaps = 71/354 (20%) Query: 11 LKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVV 70 + GH + A P +++ + D T +W + + P L+GH ++V V Sbjct: 139 IAGHGSTILCSAFAPHTSSRMVTGAGDNTARIW-----DCDTQTPMHTLKGHYNWVLCVS 193 Query: 71 ISSDGQFALSGSWDGTLRLWDLTTGTTT-RRFVGHTKDVLSVAFSS-------DNRQIVS 122 S DG+ +GS D T+RLWD +G GH+K + S+++ ++ S Sbjct: 194 WSPDGEVIATGSMDNTIRLWDPKSGQCLGDALRGHSKWITSLSWEPIHLVKPGSKPRLAS 253 Query: 123 GSRDKTIKLWNTLG-VCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLAN 181 S+D TIK+W+T+ VC+YT+ H+ VSCV++ ++ S D+ V+VW++ + Sbjct: 254 SSKDGTIKIWDTVSRVCQYTM--SGHTNSVSCVKW---GGQGLLYSGSHDRTVRVWDINS 308 Query: 182 CKLKTNHI-GHTGYLNTVTVSPDGSL-----------------------------CASGG 211 N + H ++N +++S D +L C G Sbjct: 309 QGRCINILKSHAHWVNHLSLSTDYALRIGAFDHTGKKPSTPEEAQKKALENYEKICKKNG 368 Query: 212 KDGQAM----------LWD-LNEGKHLYTLDGGD-IINALCFSPN-RYWLCAATGPSIKI 258 + M LW+ L K + + G ++N + FSP+ RY + A+ SIK+ Sbjct: 369 NSEEMMVTASDDYTMFLWNPLKSTKPIARMTGHQKLVNHVAFSPDGRYIVSASFDNSIKL 428 Query: 259 WDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQV 312 WD + + V S +AWS+D + L + D ++VW V Sbjct: 429 WDGRDGKFISTFRGHVASV---------YQVAWSSDCRLLVSCSKDTTLKVWDV 473 Score = 28.5 bits (62), Expect = 4.2, Method: Compositional matrix adjust. Identities = 10/27 (37%), Positives = 16/27 (59%) Query: 289 LAWSADGQTLFAGYTDNLVRVWQVTIG 315 ++WS DG+ + G DN +R+W G Sbjct: 192 VSWSPDGEVIATGSMDNTIRLWDPKSG 218 >6QX9-4B nrPDB Length = 522 Score = 82.4 bits (202), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 51/160 (31%), Positives = 74/160 (46%), Gaps = 4/160 (2%) Query: 61 GHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQI 120 GHS V D+ DG A +G D R+WDL TG GH K++ + FS + I Sbjct: 363 GHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHI 422 Query: 121 VSGSRDKTIKLWNTLG-VCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNL 179 +GS D T K+W+ C YT+ +H V+ V+F P N +++ +D K+W Sbjct: 423 ATGSGDNTCKVWDLRQRRCVYTIP--AHQNLVTGVKFEPIHGN-FLLTGAYDNTAKIWTH 479 Query: 180 ANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLW 219 GH G + + +S DG L A+ D LW Sbjct: 480 PGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519 Score = 72.4 bits (176), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 64/256 (25%), Positives = 111/256 (43%), Gaps = 23/256 (8%) Query: 66 VSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAF------SSDNRQ 119 +S S + + + W G +LW + GH +V ++ F S D + Sbjct: 234 ISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKD 293 Query: 120 I--VSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVW 177 + S + D ++KLW +L + E H+ V+ V + P S + + +D+ ++W Sbjct: 294 VNLASCAADGSVKLW-SLDSDEPVADIEGHTVRVARVMWHP--SGRFLGTTCYDRSWRLW 350 Query: 178 NLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGG-DII 236 +L + + GH+ + + DGSL +GG D +WDL G+ + L+G I Sbjct: 351 DLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEI 410 Query: 237 NALCFSPNRYWLCAATGP-SIKIWDLEGKIIVDEL-KQEVISTSSKAEPPQCTSLAWSAD 294 + FSPN Y + +G + K+WDL + V + + + T K EP Sbjct: 411 YGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEP---------IH 461 Query: 295 GQTLFAGYTDNLVRVW 310 G L G DN ++W Sbjct: 462 GNFLLTGAYDNTAKIW 477 Score = 49.3 bits (116), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 45/175 (25%), Positives = 75/175 (42%), Gaps = 21/175 (12%) Query: 151 VSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYL--------NTVTVSP 202 +S FSPNS ++ + W L K+W++ +C L GH + +TV++ P Sbjct: 234 ISYCHFSPNSK--MLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDP 291 Query: 203 DGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDI-INALCFSPN-RYWLCAATGPSIKIWD 260 AS DG LW L+ + + ++G + + + + P+ R+ S ++WD Sbjct: 292 KDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWD 351 Query: 261 LEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIG 315 LE + + L QE S +A+ DG G D RVW + G Sbjct: 352 LEAQEEI--LHQEGHSMG-------VYDIAFHQDGSLAGTGGLDAFGRVWDLRTG 397 Score = 29.3 bits (64), Expect = 2.6, Method: Compositional matrix adjust. Identities = 30/137 (21%), Positives = 54/137 (39%), Gaps = 21/137 (15%) Query: 187 NHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDI-INALCFSPN- 244 + IG ++ SP+ + A+ G LW + + L+TL G + + A+ F P Sbjct: 226 SQIGDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKS 285 Query: 245 ---------RYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADG 295 CAA G S+K+W L+ V +++ + + + W G Sbjct: 286 TVSLDPKDVNLASCAADG-SVKLWSLDSDEPVADIEGHTV---------RVARVMWHPSG 335 Query: 296 QTLFAGYTDNLVRVWQV 312 + L D R+W + Sbjct: 336 RFLGTTCYDRSWRLWDL 352 >6ID0-T nrPDB Length = 514 Score = 81.6 bits (200), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 68/256 (26%), Positives = 111/256 (43%), Gaps = 13/256 (5%) Query: 7 LRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFV 66 L + GH GWV IA P ++ S D+TI +W L G + +L GH V Sbjct: 196 LYRVISGHLGWVRCIAVEPGN-QWFVTGSADRTIKIWDLAS-----GKLKLSLTGHISTV 249 Query: 67 SDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRD 126 V++S+ + S D ++ WDL R + GH V + +V+ SRD Sbjct: 250 RGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRD 309 Query: 127 KTIKLWNTLGVCKYTVQDES-HSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLK 185 T ++W+ K +V S H+ V+ VR ++ P I++ D +++W+L K + Sbjct: 310 STARIWDVR--TKASVHTLSGHTNAVATVRC--QAAEPQIITGSHDTTIRLWDLVAGKTR 365 Query: 186 TNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGD-IINALCFSPN 244 H + V + P ASG D W +G + L G + IIN L + + Sbjct: 366 VTLTNHKKSVRAVVLHPRHYTFASGSPDNIKQ-WKFPDGSFIQNLSGHNAIINTLTVNSD 424 Query: 245 RYWLCAATGPSIKIWD 260 + A ++ +WD Sbjct: 425 GVLVSGADNGTMHLWD 440 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 54/215 (25%), Positives = 87/215 (40%), Gaps = 4/215 (1%) Query: 57 RALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSD 116 R + GH +V + + Q+ ++GS D T+++WDL +G GH V V S+ Sbjct: 198 RVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTR 257 Query: 117 NRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKV 176 + + S DK +K W+ L K H V + P ++V+C D ++ Sbjct: 258 SPYLFSCGEDKQVKCWD-LEYNKVIRHYHGHLSAVYGLDLHPTID--VLVTCSRDSTARI 314 Query: 177 WNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTL-DGGDI 235 W++ GHT + TV +G D LWDL GK TL + Sbjct: 315 WDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKS 374 Query: 236 INALCFSPNRYWLCAATGPSIKIWDLEGKIIVDEL 270 + A+ P Y + + +IK W + L Sbjct: 375 VRAVVLHPRHYTFASGSPDNIKQWKFPDGSFIQNL 409 Score = 41.6 bits (96), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 42/170 (24%), Positives = 68/170 (40%), Gaps = 52/170 (30%) Query: 10 TLKGHNGWVTQI---ATTPQFPDMILSASRDKTIIMWKLTRDET-----NYGIPQRA--- 58 TL GH V + A PQ I++ S D TI +W L +T N+ RA Sbjct: 325 TLSGHTNAVATVRCQAAEPQ----IITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVL 380 Query: 59 ----------------------------LRGHSHFVSDVVISSDGQFALSGSWDGTLRLW 90 L GH+ ++ + ++SDG +SG+ +GT+ LW Sbjct: 381 HPRHYTFASGSPDNIKQWKFPDGSFIQNLSGHNAIINTLTVNSDGVL-VSGADNGTMHLW 439 Query: 91 DLTTGTTTRRFVGHTKD--------VLSVAFSSDNRQIVSGSRDKTIKLW 132 D TG +R + + + AF ++++ DKTIK++ Sbjct: 440 DWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESRLLTAEADKTIKVY 489 >5NZU-C nrPDB Length = 905 Score = 80.9 bits (198), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 62/230 (26%), Positives = 103/230 (44%), Gaps = 18/230 (7%) Query: 51 NYGIPQRA--LRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTG-TTTRRFVGHTKD 107 NY +R HS ++ + + F L+ S D ++LWD + ++ F GHT Sbjct: 85 NYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHY 144 Query: 108 VLSVAFS-SDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIV 166 V+ + + DN Q S S D+TIK+W LG E H + V+C+ + P ++ Sbjct: 145 VMQIVINPKDNNQFASASLDRTIKVWQ-LGSSSPNFTLEGHEKGVNCIDYYSGGDKPYLI 203 Query: 167 SCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKH 226 S D+LVK+W+ N GH ++ + P+ + +G +DG +W Sbjct: 204 SGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIIITGSEDGTVRIWH----SS 259 Query: 227 LYTLDGGDIINALCFSPNRYWLCAATGPSIKI---WDLEGKIIVDELKQE 273 Y L+ + L + R W A+ S + +D EG IIV ++E Sbjct: 260 TYRLE-----STLNYGMERVWCVASLRGSNNVALGYD-EGSIIVKLGREE 303 Score = 70.9 bits (172), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 61/263 (23%), Positives = 114/263 (43%), Gaps = 20/263 (7%) Query: 56 QRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSS 115 +R L S V V + + L+ ++G++ +W+ T T + F V + F + Sbjct: 8 KRKLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVA 67 Query: 116 DNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVK 175 +V+G+ D I+++N + E+HS+++ C+ P + P I++ D L+K Sbjct: 68 RKNWVVTGADDMQIRVFN-YNTLERVHMFEAHSDYIRCIAVHP--TQPFILTSSDDMLIK 124 Query: 176 VWNLANCKLKTNHI--GHTGYLNTVTVSP-DGSLCASGGKDGQAMLWDLNEGKHLYTLDG 232 +W+ + K + + GHT Y+ + ++P D + AS D +W L +TL+G Sbjct: 125 LWDW-DKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEG 183 Query: 233 GD----IINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTS 288 + I+ Y + A +KIWD + K V L+ + S + P+ Sbjct: 184 HEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELP- 242 Query: 289 LAWSADGQTLFAGYTDNLVRVWQ 311 + G D VR+W Sbjct: 243 --------IIITGSEDGTVRIWH 257 Score = 67.8 bits (164), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 37/127 (29%), Positives = 64/127 (50%), Gaps = 7/127 (5%) Query: 10 TLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVS-- 67 +GH +V QI P+ + SAS D+TI +W+L N+ L GH V+ Sbjct: 137 VFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNF-----TLEGHEKGVNCI 191 Query: 68 DVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDK 127 D D + +SG+ D +++WD T + GH ++V +F + I++GS D Sbjct: 192 DYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIIITGSEDG 251 Query: 128 TIKLWNT 134 T+++W++ Sbjct: 252 TVRIWHS 258 >5Y88-O nrPDB Length = 451 Score = 80.5 bits (197), Expect = 8e-16, Method: Compositional matrix adjust. Identities = 61/215 (28%), Positives = 95/215 (44%), Gaps = 6/215 (2%) Query: 57 RALRGHSHFVSDVVISS-DGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSS 115 R + GH +V V I D ++ ++GS D T+++WDL TG GH V VA S Sbjct: 133 RVINGHLGWVRCVAIDPVDNEWFITGSNDTTMKVWDLATGKLKTTLAGHVMTVRDVAVSD 192 Query: 116 DNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVK 175 + + S S DKT+K W+ L + H V V P +I + G D ++K Sbjct: 193 RHPYLFSVSEDKTVKCWD-LEKNQIIRDYYGHLSGVRTVSIHPTLD--LIATAGRDSVIK 249 Query: 176 VWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTL-DGGD 234 +W++ +GH G +N V +P S D LWD+ GK + L Sbjct: 250 LWDMRTRIPVITLVGHKGPINQVQCTPVDPQVVSSSTDATVRLWDVVAGKTMKVLTHHKR 309 Query: 235 IINALCFSPNRYWLCAATGPSIKIWDL-EGKIIVD 268 + A P + + +A I+ W L EG ++ + Sbjct: 310 SVRATALHPKEFSVASACTDDIRSWGLAEGSLLTN 344 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 73/308 (23%), Positives = 121/308 (39%), Gaps = 14/308 (4%) Query: 7 LRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFV 66 L + GH GWV +A P + ++ S D T+ +W L G + L GH V Sbjct: 131 LSRVINGHLGWVRCVAIDPVDNEWFITGSNDTTMKVWDLAT-----GKLKTTLAGHVMTV 185 Query: 67 SDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRD 126 DV +S + S S D T++ WDL R + GH V +V+ I + RD Sbjct: 186 RDVAVSDRHPYLFSVSEDKTVKCWDLEKNQIIRDYYGHLSGVRTVSIHPTLDLIATAGRD 245 Query: 127 KTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKT 186 IKLW+ + + H ++ V+ +P +P +VS D V++W++ K Sbjct: 246 SVIKLWD-MRTRIPVITLVGHKGPINQVQCTP--VDPQVVSSSTDATVRLWDVVAGKTMK 302 Query: 187 NHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGD--IINALCFSPN 244 H + + P AS D W L EG L + IIN L + + Sbjct: 303 VLTHHKRSVRATALHPKEFSVASACTD-DIRSWGLAEGSLLTNFESEKTGIINTLSINQD 361 Query: 245 RYWLCAATGPSIKIWDLEGKIIVDELK-QEVISTSSKAEPPQCTSLAWSADGQTLFAGYT 303 + +D + L +E++ + C++ + G L G Sbjct: 362 DVLFAGGDNGVLSFYDYKSGHKYQSLATREMVGSLEGERSVLCST--FDKTGLRLITGEA 419 Query: 304 DNLVRVWQ 311 D +++W+ Sbjct: 420 DKSIKIWK 427 >4V7E-Bg nrPDB Length = 380 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 81/328 (24%), Positives = 148/328 (45%), Gaps = 38/328 (11%) Query: 10 TLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWK-LTRDETNYGIPQRALRGHSHFVSD 68 TL+GH+G V + TP+ + I+SAS+D +I+W LT +T+ A++ H +V + Sbjct: 61 TLQGHSGKVYSLDWTPE-KNWIVSASQDGRLIVWNALTSQKTH------AIKLHCPWVME 113 Query: 69 VVISSDGQFALSGSWDGTLRLWDLTTGT-------TTRRFVGHTKDVLSVAFSSDNR-QI 120 + +GQ G D +++L++ +R GH S + D ++ Sbjct: 114 CAFAPNGQSVACGGLDSACSIFNLSSQADRDGNMPVSRVLTGHKGYASSCQYVPDQETRL 173 Query: 121 VSGSRDKTIKLWNTLGVCKYTV--QDESHSEWVSCVRFSPNSSNP-IIVSCGWDKLVKVW 177 ++GS D+T LW+ + ++ + + S NS N + +S D V++W Sbjct: 174 ITGSGDQTCVLWDVTTGQRISIFGSEFPSGHTADVLSLSINSLNANMFISGSCDTTVRLW 233 Query: 178 NL--ANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTL----D 231 +L + ++T H GH G +N+V PDG +G DG L+D+ G L D Sbjct: 234 DLRITSRAVRTYH-GHEGDINSVKFFPDGQRFGTGSDDGTCRLFDMRTGHQLQVYNREPD 292 Query: 232 GGD----IINALCFS-PNRYWLCAATGPSIKIWD-LEGKIIVDELKQEVISTSSKAEPPQ 285 D I+ ++ FS R + +WD L +++++ + T + + Sbjct: 293 RNDNELPIVTSVAFSISGRLLFAGYSNGDCYVWDTLLAEMVLN------LGTLQNSHEGR 346 Query: 286 CTSLAWSADGQTLFAGYTDNLVRVWQVT 313 + L S+DG L G D +++W + Sbjct: 347 ISCLGLSSDGSALCTGSWDKNLKIWAFS 374 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 62/232 (26%), Positives = 102/232 (43%), Gaps = 22/232 (9%) Query: 4 QMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHS 63 M + L GH G+ + P +++ S D+T ++W +T + GH+ Sbjct: 146 NMPVSRVLTGHKGYASSCQYVPDQETRLITGSGDQTCVLWDVTTGQRISIFGSEFPSGHT 205 Query: 64 HFVSDVVISS-DGQFALSGSWDGTLRLWDL-TTGTTTRRFVGHTKDVLSVAFSSDNRQIV 121 V + I+S + +SGS D T+RLWDL T R + GH D+ SV F D ++ Sbjct: 206 ADVLSLSINSLNANMFISGSCDTTVRLWDLRITSRAVRTYHGHEGDINSVKFFPDGQRFG 265 Query: 122 SGSRDKTIKLWNTLGVCKYTV------QDESHSEWVSCVRFSPN--------SSNPIIVS 167 +GS D T +L++ + V ++++ V+ V FS + S+ V Sbjct: 266 TGSDDGTCRLFDMRTGHQLQVYNREPDRNDNELPIVTSVAFSISGRLLFAGYSNGDCYV- 324 Query: 168 CGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLW 219 WD L+ L L T H G ++ + +S DGS +G D +W Sbjct: 325 --WDTLLAEMVL---NLGTLQNSHEGRISCLGLSSDGSALCTGSWDKNLKIW 371 Score = 57.8 bits (138), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 61/274 (22%), Positives = 115/274 (41%), Gaps = 18/274 (6%) Query: 57 RALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSD 116 R L+GHS V + + + + +S S DG L +W+ T T H V+ AF+ + Sbjct: 60 RTLQGHSGKVYSLDWTPEKNWIVSASQDGRLIVWNALTSQKTHAIKLHCPWVMECAFAPN 119 Query: 117 NRQIVSGSRDKTIKLWNTL------GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGW 170 + + G D ++N G + H + S ++ P+ +I G Sbjct: 120 GQSVACGGLDSACSIFNLSSQADRDGNMPVSRVLTGHKGYASSCQYVPDQETRLITGSG- 178 Query: 171 DKLVKVWNLANCKLKTNH-----IGHTGYLNTVTV-SPDGSLCASGGKDGQAMLWDL--- 221 D+ +W++ + + GHT + ++++ S + ++ SG D LWDL Sbjct: 179 DQTCVLWDVTTGQRISIFGSEFPSGHTADVLSLSINSLNANMFISGSCDTTVRLWDLRIT 238 Query: 222 NEGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKA 281 + Y GDI + F + + + + +++D+ + +E + Sbjct: 239 SRAVRTYHGHEGDINSVKFFPDGQRFGTGSDDGTCRLFDMRTGHQLQVYNRE--PDRNDN 296 Query: 282 EPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIG 315 E P TS+A+S G+ LFAGY++ VW + Sbjct: 297 ELPIVTSVAFSISGRLLFAGYSNGDCYVWDTLLA 330 Score = 28.9 bits (63), Expect = 3.1, Method: Compositional matrix adjust. Identities = 17/47 (36%), Positives = 23/47 (48%), Gaps = 9/47 (19%) Query: 62 HSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDV 108 H +S + +SSDG +GSWD L++W F GH K V Sbjct: 343 HEGRISCLGLSSDGSALCTGSWDKNLKIW---------AFSGHRKIV 380 >5K1B-B nrPDB Length = 677 Score = 78.6 bits (192), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 55/205 (26%), Positives = 97/205 (47%), Gaps = 8/205 (3%) Query: 31 ILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLW 90 + +A RD I +W + + + + I ++ H+ +V+D+V+ +G+ +S S D T+++W Sbjct: 45 LFTAGRDSIIRIWSVNQHKQDPYIA--SMEHHTDWVNDIVLCCNGKTLISASSDTTVKVW 102 Query: 91 DLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWN-----TLGVCKYTVQDE 145 + G H V ++A++ D + S D+ I LW+ L TV Sbjct: 103 NAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTS 162 Query: 146 SHS-EWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDG 204 S S S + N IIVS +K+++VW+ C GHT + + ++ DG Sbjct: 163 SLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDG 222 Query: 205 SLCASGGKDGQAMLWDLNEGKHLYT 229 + C SG DG LW L + + + T Sbjct: 223 TQCLSGSSDGTIRLWSLGQQRCIAT 247 Score = 62.8 bits (151), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 42/144 (29%), Positives = 71/144 (49%), Gaps = 10/144 (6%) Query: 10 TLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTR----DETNYGIPQRALRGHSHF 65 TL+ H +V +A +++ SA D+ I +W + +N + +L G+ Sbjct: 112 TLRTHKDYVKALAYAKD-KELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDS 170 Query: 66 VSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSR 125 + + ++ G +SGS + LR+WD T + GHT +V ++ + D Q +SGS Sbjct: 171 IYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSS 230 Query: 126 DKTIKLWNTLG----VCKYTVQDE 145 D TI+LW +LG + Y V DE Sbjct: 231 DGTIRLW-SLGQQRCIATYRVHDE 253 Score = 55.1 bits (131), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 54/212 (25%), Positives = 82/212 (38%), Gaps = 31/212 (14%) Query: 117 NRQIVSGSRDKTIKLW--NTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLV 174 NR +G RD I++W N Y E H++WV+ + N ++S D V Sbjct: 43 NRLFTAG-RDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKT--LISASSDTTV 99 Query: 175 KVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGD 234 KVWN + H Y+ + + D L AS G D Q LWD+N Sbjct: 100 KVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVN------------ 147 Query: 235 IINALCFSPNRYWLCAATGPSIKIWDLE----GKIIVDELKQEVIST----------SSK 280 + AL S N + +G I+ L G IIV ++V+ K Sbjct: 148 TLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLK 207 Query: 281 AEPPQCTSLAWSADGQTLFAGYTDNLVRVWQV 312 +L + DG +G +D +R+W + Sbjct: 208 GHTDNVKALLLNRDGTQCLSGSSDGTIRLWSL 239 Score = 46.6 bits (109), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 33/120 (27%), Positives = 57/120 (47%), Gaps = 6/120 (5%) Query: 10 TLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDV 69 +L G+ + +A Q +I+S S +K + +W + L+GH+ V + Sbjct: 163 SLSGNKDSIYSLAMN-QLGTIIVSGSTEKVLRVW-----DPRTCAKLMKLKGHTDNVKAL 216 Query: 70 VISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTI 129 +++ DG LSGS DGT+RLW L + H + V ++ + + SG RD+ I Sbjct: 217 LLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKI 276 >4J0W-A nrPDB Length = 343 Score = 77.4 bits (189), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 62/225 (27%), Positives = 102/225 (45%), Gaps = 14/225 (6%) Query: 10 TLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRG-------H 62 L+GH +T + TP I SA++D +II W + + IP RA +G H Sbjct: 9 VLRGHQLSITCLVVTPD-DSAIFSAAKDCSIIKWSVESGRKLHVIP-RAKKGAEGKPPGH 66 Query: 63 SHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVS 122 S V + ISSDG++ SG + +W+ + F GH V +AF Q+ S Sbjct: 67 SSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYS 126 Query: 123 GSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANC 182 S D+++K+WN + Y H + V+ S + + G D V+VW + Sbjct: 127 TSHDRSVKVWN-VAENSYVETLFGHQDAVAA--LDALSRECCVTAGGRDGTVRVWKIPE- 182 Query: 183 KLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHL 227 + + GH G ++ + + + + SG DG LW L++ + L Sbjct: 183 ESQLVFYGHQGSIDCIHLINEEHM-VSGADDGSVALWGLSKKRPL 226 Score = 74.3 bits (181), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 63/274 (22%), Positives = 109/274 (39%), Gaps = 16/274 (5%) Query: 57 RALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTR-----------RFVGHT 105 R LRGH ++ +V++ D S + D ++ W + +G + GH+ Sbjct: 8 RVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHS 67 Query: 106 KDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPII 165 VL +A SSD + + SG R K I +W C++ H + VS + F + + Sbjct: 68 SHVLCMAISSDGKYLASGDRSKLILIWEAQS-CQHLYTFTGHRDAVSGLAFRRGTHQ--L 124 Query: 166 VSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGK 225 S D+ VKVWN+A GH + + +GG+DG +W + E Sbjct: 125 YSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEES 184 Query: 226 HLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGK--IIVDELKQEVISTSSKAEP 283 L I+ + + + A S+ +W L K + + + +P Sbjct: 185 QLVFYGHQGSIDCIHLINEEHMVSGADDGSVALWGLSKKRPLALQREAHGLRGEPGLEQP 244 Query: 284 PQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGTR 317 +S+A + + G + VR+WQ G R Sbjct: 245 FWISSVAALLNTDLVATGSHSSCVRLWQCGEGFR 278 >5WYJ-BC nrPDB Length = 817 Score = 76.6 bits (187), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 53/218 (24%), Positives = 96/218 (44%), Gaps = 16/218 (7%) Query: 13 GHNGWVTQIA----TTPQFPDMILSASRDKTIIMWKLTR-----DETNYGIPQRALRGHS 63 GH+ VT + + +P+ +L+AS D TI W + + D + + H Sbjct: 432 GHSAAVTAVGLPNIVSKGYPEFLLTASNDLTIKKWIIPKPTASMDVQIIKVSEYTRHAHE 491 Query: 64 HFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSG 123 ++ + +S + + S+D T ++W+L G H + + V+F ++ + + Sbjct: 492 KDINALSVSPNDSIFATASYDKTCKIWNLENGELEATLANHKRGLWDVSFCQYDKLLATS 551 Query: 124 SRDKTIKLW--NTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLAN 181 S DKT+K+W +T V K E H+ V F ++SCG D L+K+W+ ++ Sbjct: 552 SGDKTVKIWSLDTFSVMKTL---EGHTNAVQRCSFINKQKQ--LISCGADGLIKIWDCSS 606 Query: 182 CKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLW 219 + GH L ++ DG + S DG W Sbjct: 607 GECLKTLDGHNNRLWALSTMNDGDMIVSADADGVFQFW 644 Score = 67.4 bits (163), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 63/234 (26%), Positives = 104/234 (44%), Gaps = 32/234 (13%) Query: 31 ILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDV---VISSDG--QFALSGSWDG 85 I +AS+D T I+W+ + + I + + GHS V+ V I S G +F L+ S D Sbjct: 403 IATASKDNTAIVWRYNENSCKFDIYAKYI-GHSAAVTAVGLPNIVSKGYPEFLLTASNDL 461 Query: 86 TLRLWDLTTGTTTRRFV----------GHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTL 135 T++ W + T + H KD+ +++ S ++ + S DKT K+WN Sbjct: 462 TIKKWIIPKPTASMDVQIIKVSEYTRHAHEKDINALSVSPNDSIFATASYDKTCKIWNLE 521 Query: 136 -GVCKYTVQDESHSEW-VSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTG 193 G + T+ + W VS ++ + ++ + DK VK+W+L + GHT Sbjct: 522 NGELEATLANHKRGLWDVSFCQY-----DKLLATSSGDKTVKIWSLDTFSVMKTLEGHTN 576 Query: 194 YLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYW 247 + + S G DG +WD + G+ L TLDG + NR W Sbjct: 577 AVQRCSFINKQKQLISCGADGLIKIWDCSSGECLKTLDGHN---------NRLW 621 Score = 58.5 bits (140), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 63/277 (22%), Positives = 117/277 (42%), Gaps = 31/277 (11%) Query: 10 TLKGHNGWVTQIATT-PQFPDMILSASRD--KTIIMWKLTRDETNYGIPQRALRGHSHFV 66 ++ G++G + + P+ + L+ + + I + L+ E + + GH + Sbjct: 332 SIAGNHGIIADMRYVGPELNKLALATNSPSLRIIPVPDLSGPEASLPLDVEIYEGHEDLL 391 Query: 67 SDVVISSDGQFALSGSWDGTLRLWDLTTGTTT----RRFVGHTKDVLSVAFSSDNRQ--- 119 + + + DG + + S D T +W + +++GH+ V +V + + Sbjct: 392 NSLDATEDGLWIATASKDNTAIVWRYNENSCKFDIYAKYIGHSAAVTAVGLPNIVSKGYP 451 Query: 120 --IVSGSRDKTIKLW-----------NTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIV 166 +++ S D TIK W + V +YT +H + ++ + SPN S I Sbjct: 452 EFLLTASNDLTIKKWIIPKPTASMDVQIIKVSEYTRH--AHEKDINALSVSPNDS--IFA 507 Query: 167 SCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKH 226 + +DK K+WNL N +L+ H L V+ L A+ D +W L+ Sbjct: 508 TASYDKTCKIWNLENGELEATLANHKRGLWDVSFCQYDKLLATSSGDKTVKIWSLDTFSV 567 Query: 227 LYTLDGG-DIINALCFSPNRYWL--CAATGPSIKIWD 260 + TL+G + + F + L C A G IKIWD Sbjct: 568 MKTLEGHTNAVQRCSFINKQKQLISCGADG-LIKIWD 603 Score = 34.7 bits (78), Expect = 0.063, Method: Compositional matrix adjust. Identities = 26/106 (24%), Positives = 52/106 (49%), Gaps = 7/106 (6%) Query: 81 GSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSD-NRQI---VSGSRDKTIKLWNTLG 136 G DG++ + D+ G T F GH + S+ F N +I SG + +K+W+ + Sbjct: 120 GGTDGSIIVVDIENGYITHSFKGHGGTISSLKFYGQLNSKIWLLASGDTNGMVKVWDLVK 179 Query: 137 -VCKYTVQDESHSEWVSCVRFSPNSSNPI--IVSCGWDKLVKVWNL 179 C +T+Q+ + + + P++ P ++S G D ++ +W+ Sbjct: 180 RKCLHTLQEHTSAVRGLDIIEVPDNDEPSLNLLSGGRDDIINLWDF 225 Score = 30.4 bits (67), Expect = 1.2, Method: Compositional matrix adjust. Identities = 19/60 (31%), Positives = 28/60 (46%), Gaps = 6/60 (10%) Query: 80 SGSWDGTLRLWDLTTGTTTRRFVGHTKDV--LSVAFSSDNRQ----IVSGSRDKTIKLWN 133 SG +G +++WDL HT V L + DN + ++SG RD I LW+ Sbjct: 165 SGDTNGMVKVWDLVKRKCLHTLQEHTSAVRGLDIIEVPDNDEPSLNLLSGGRDDIINLWD 224 Score = 27.3 bits (59), Expect = 8.5, Method: Compositional matrix adjust. Identities = 29/118 (24%), Positives = 50/118 (42%), Gaps = 12/118 (10%) Query: 156 FSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGS----LCASGG 211 +S++ ++ G D + V ++ N + + GH G ++++ + L ASG Sbjct: 108 LDADSTSTLLAVGGTDGSIIVVDIENGYITHSFKGHGGTISSLKFYGQLNSKIWLLASGD 167 Query: 212 KDGQAMLWDLNEGKHLYTLD-------GGDIINAL-CFSPNRYWLCAATGPSIKIWDL 261 +G +WDL + K L+TL G DII P+ L I +WD Sbjct: 168 TNGMVKVWDLVKRKCLHTLQEHTSAVRGLDIIEVPDNDEPSLNLLSGGRDDIINLWDF 225 >6EMK-B nrPDB Length = 303 Score = 75.5 bits (184), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 72/296 (24%), Positives = 133/296 (44%), Gaps = 31/296 (10%) Query: 30 MILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRL 89 +++SA D TI W E G+ R ++ V+ + I++D + L+ + +RL Sbjct: 4 ILVSAGYDHTIRFW-----EALTGVCSRTIQHSDSQVNRLEITNDKKL-LATAGHQNVRL 57 Query: 90 WDL--TTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESH 147 +D+ T F GH +V SV+F DNR +V+ S D TIK+W+ ++ H Sbjct: 58 YDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRS--PSIPRNYKH 115 Query: 148 SEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLA--NCKLKTNHIGHTGYLNTVTVSPDGS 205 + V+ V PN ++SC D +++W+L C + T L +++++ DGS Sbjct: 116 NAPVNEVVIHPNQGE--LISCDRDGNIRIWDLGENQCTHQLTPEDDTS-LQSLSMASDGS 172 Query: 206 LCASGGKDGQAMLWDL---NEGKHL-----YTLDGGDIINALCFSPNRYWLCAATGPSIK 257 + A+ G +W++ + HL + I L S ++ + + + Sbjct: 173 MLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTAR 232 Query: 258 IWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVT 313 +W ++ D+ K E + C A+SAD L +D+ VR+W ++ Sbjct: 233 VWSID-----DDFKLETTLDGHQRWVWDC---AFSADSAYLVTASSDHYVRLWDLS 280 Score = 53.1 bits (126), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 42/185 (22%), Positives = 82/185 (44%), Gaps = 15/185 (8%) Query: 14 HNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGI-PQRALRGHSHFVSDVVIS 72 HN V ++ P ++I S RD I +W L ++ + + P+ S + ++ Sbjct: 115 HNAPVNEVVIHPNQGELI-SCDRDGNIRIWDLGENQCTHQLTPEDDTSLQS-----LSMA 168 Query: 73 SDGQFALSGSWDGTLRLWDLTTGTTTR------RFVGHTKDVLSVAFSSDNRQIVSGSRD 126 SDG + + G +W++ T +F H+ + + SSD + + + S D Sbjct: 169 SDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSAD 228 Query: 127 KTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKT 186 T ++W+ K + H WV FS +S+ +V+ D V++W+L+ ++ Sbjct: 229 HTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSA--YLVTASSDHYVRLWDLSTREIVR 286 Query: 187 NHIGH 191 + GH Sbjct: 287 QYGGH 291 Score = 48.1 bits (113), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 29/104 (27%), Positives = 53/104 (50%), Gaps = 5/104 (4%) Query: 11 LKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVV 70 + H+ ++T+I + + + S D T +W + D + + + L GH +V D Sbjct: 203 FRAHSTYITRILLSSDVKHLA-TCSADHTARVWSIDDD---FKL-ETTLDGHQRWVWDCA 257 Query: 71 ISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFS 114 S+D + ++ S D +RLWDL+T R++ GH K + VA + Sbjct: 258 FSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALN 301 >5FVM-C nrPDB Length = 303 Score = 74.7 bits (182), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 76/297 (25%), Positives = 134/297 (45%), Gaps = 33/297 (11%) Query: 30 MILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRL 89 ++ SA D TI W E G+ R ++ V+ + I+SD ++ L+ + +RL Sbjct: 4 ILASAGYDHTIRFW-----EALTGVCSRTIQHADSQVNRLEITSDKKY-LAAAGHLHVRL 57 Query: 90 WDLTTGTTT--RRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQ-DES 146 +D+ + F GH +V S+AF +NR +VS S D TIK+W+ V +VQ + Sbjct: 58 YDIRSNNPNPVSSFEGHKGNVTSIAFQQENRWMVSSSEDGTIKVWD---VRSPSVQRNYK 114 Query: 147 HSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHI--GHTGYLNTVTVSPDG 204 H+ V+ V PN ++SC D +++W+L + TN + L +++V+ DG Sbjct: 115 HNAPVNEVAIHPNQGE--LISCDQDGNIRIWDLGENQC-TNQLTPEDNTPLQSLSVASDG 171 Query: 205 SLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCA--------ATGPSI 256 S+ +G G +W + TL+ + R L A + + Sbjct: 172 SMLVAGNNKGNCYVWRMPHHTDASTLEPVTKFKSHTKYITRVLLSADVKNLATCSADHTA 231 Query: 257 KIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVT 313 ++W++E D + E + C A+SAD L +D+ VR+W ++ Sbjct: 232 RVWNIE-----DNYQLETTLDGHQRWVWDC---AFSADSAYLVTACSDHYVRLWDLS 280 Score = 61.6 bits (148), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 48/185 (25%), Positives = 87/185 (47%), Gaps = 15/185 (8%) Query: 14 HNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDE-TNYGIPQRALRGHSHFVSDVVIS 72 HN V ++A P ++I S +D I +W L ++ TN P+ S + ++ Sbjct: 115 HNAPVNEVAIHPNQGELI-SCDQDGNIRIWDLGENQCTNQLTPEDNTPLQS-----LSVA 168 Query: 73 SDGQFALSGSWDGTLRLW------DLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRD 126 SDG ++G+ G +W D +T +F HTK + V S+D + + + S D Sbjct: 169 SDGSMLVAGNNKGNCYVWRMPHHTDASTLEPVTKFKSHTKYITRVLLSADVKNLATCSAD 228 Query: 127 KTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKT 186 T ++WN + + H WV FS +S+ ++ +C D V++W+L+ ++ Sbjct: 229 HTARVWNIEDNYQLETTLDGHQRWVWDCAFSADSAY-LVTACS-DHYVRLWDLSTSEIVR 286 Query: 187 NHIGH 191 + GH Sbjct: 287 QYGGH 291 Score = 52.8 bits (125), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 30/104 (28%), Positives = 53/104 (50%), Gaps = 5/104 (4%) Query: 11 LKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVV 70 K H ++T++ + ++ + S D T +W + E NY + + L GH +V D Sbjct: 203 FKSHTKYITRVLLSADVKNLA-TCSADHTARVWNI---EDNYQL-ETTLDGHQRWVWDCA 257 Query: 71 ISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFS 114 S+D + ++ D +RLWDL+T R++ GH K + VA + Sbjct: 258 FSADSAYLVTACSDHYVRLWDLSTSEIVRQYGGHHKGAVCVALN 301 >4LG8-A nrPDB Length = 354 Score = 73.2 bits (178), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 57/239 (23%), Positives = 105/239 (43%), Gaps = 13/239 (5%) Query: 25 PQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWD 84 P + IL+ DK ++++ + ++ L+GH+ V+ VV S S D Sbjct: 81 PSDTNKILTGGADKNVVVFDKSSEQI-----LATLKGHTKKVTSVVFHPSQDLVFSASPD 135 Query: 85 GTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNT-LGVCKYTVQ 143 T+R+W + + + H V ++ + ++S S D+ + G V Sbjct: 136 ATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVT 195 Query: 144 DESHSEWVSCVRFSPNSSNPIIVSCG-WDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSP 202 DE+ ++C +F P+ +I G D +K+W+L N GH+G + ++ S Sbjct: 196 DETSGCSLTCAQFHPDG---LIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSE 252 Query: 203 DGSLCASGGKDGQAMLWDLNEGKHLYT--LDGGDIINALCFSPNRYWLCAATGPSIKIW 259 +G A+ D LWDL + K+ T LD + +L F + +L A G ++I+ Sbjct: 253 NGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYL-ALGGTDVQIY 310 Score = 52.8 bits (125), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 41/171 (23%), Positives = 67/171 (39%), Gaps = 50/171 (29%) Query: 7 LRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFV 66 + TLKGH VT + P D++ SAS D TI +W + N Q +R H V Sbjct: 106 ILATLKGHTKKVTSVVFHPS-QDLVFSASPDATIRIWSVP----NASCVQ-VVRAHESAV 159 Query: 67 SDVVISSDGQFALS--------------------------------------------GS 82 + + + + G + LS G+ Sbjct: 160 TGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGT 219 Query: 83 WDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWN 133 D +++WDL T F GH+ + S+AFS + + + + D ++KLW+ Sbjct: 220 MDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWD 270 Score = 42.0 bits (97), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 45/202 (22%), Positives = 84/202 (41%), Gaps = 16/202 (7%) Query: 115 SDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLV 174 SD +I++G DK + +++ + + H++ V+ V F P S ++ S D + Sbjct: 82 SDTNKILTGGADKNVVVFDK-SSEQILATLKGHTKKVTSVVFHP--SQDLVFSASPDATI 138 Query: 175 KVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLD--- 231 ++W++ N H + +++ G S D D+ G+ L + Sbjct: 139 RIWSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDET 198 Query: 232 GGDIINALCFSPNRYWLCAATGPS-IKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLA 290 G + F P+ T S IKIWDL+ + V + + P TS+A Sbjct: 199 SGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERT-------NVANFPGHSGP--ITSIA 249 Query: 291 WSADGQTLFAGYTDNLVRVWQV 312 +S +G L D+ V++W + Sbjct: 250 FSENGYYLATAADDSSVKLWDL 271 >5Z56-q nrPDB Length = 504 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 57/239 (23%), Positives = 105/239 (43%), Gaps = 13/239 (5%) Query: 25 PQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWD 84 P + IL+ DK ++++ + ++ L+GH+ V+ VV S S D Sbjct: 231 PSDTNKILTGGADKNVVVFDKSSEQI-----LATLKGHTKKVTSVVFHPSQDLVFSASPD 285 Query: 85 GTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNT-LGVCKYTVQ 143 T+R+W + + + H V ++ + ++S S D+ + G V Sbjct: 286 ATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVT 345 Query: 144 DESHSEWVSCVRFSPNSSNPIIVSCG-WDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSP 202 DE+ ++C +F P+ +I G D +K+W+L N GH+G + ++ S Sbjct: 346 DETSGCSLTCAQFHPDG---LIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSE 402 Query: 203 DGSLCASGGKDGQAMLWDLNEGKHLYT--LDGGDIINALCFSPNRYWLCAATGPSIKIW 259 +G A+ D LWDL + K+ T LD + +L F + +L A G ++I+ Sbjct: 403 NGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYL-ALGGTDVQIY 460 Score = 53.5 bits (127), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 39/169 (23%), Positives = 65/169 (38%), Gaps = 50/169 (29%) Query: 9 GTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSD 68 TLKGH VT + P D++ SAS D TI +W + + +R H V+ Sbjct: 258 ATLKGHTKKVTSVVFHPS-QDLVFSASPDATIRIWSVPNASC-----VQVVRAHESAVTG 311 Query: 69 VVISSDGQFALS--------------------------------------------GSWD 84 + + + G + LS G+ D Sbjct: 312 LSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMD 371 Query: 85 GTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWN 133 +++WDL T F GH+ + S+AFS + + + + D ++KLW+ Sbjct: 372 SQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWD 420 Score = 40.8 bits (94), Expect = 9e-04, Method: Compositional matrix adjust. Identities = 45/202 (22%), Positives = 84/202 (41%), Gaps = 16/202 (7%) Query: 115 SDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLV 174 SD +I++G DK + +++ + + H++ V+ V F P S ++ S D + Sbjct: 232 SDTNKILTGGADKNVVVFDK-SSEQILATLKGHTKKVTSVVFHP--SQDLVFSASPDATI 288 Query: 175 KVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLD--- 231 ++W++ N H + +++ G S D D+ G+ L + Sbjct: 289 RIWSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDET 348 Query: 232 GGDIINALCFSPNRYWLCAATGPS-IKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLA 290 G + F P+ T S IKIWDL+ + V + + P TS+A Sbjct: 349 SGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERT-------NVANFPGHSGP--ITSIA 399 Query: 291 WSADGQTLFAGYTDNLVRVWQV 312 +S +G L D+ V++W + Sbjct: 400 FSENGYYLATAADDSSVKLWDL 421 >2YNP-A nrPDB Length = 604 Score = 70.9 bits (172), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 60/212 (28%), Positives = 92/212 (43%), Gaps = 20/212 (9%) Query: 7 LRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFV 66 L T +GH +V +A P+ P S D+T+ +W L + N+ + RG ++ Sbjct: 132 LEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQERGVNYV- 190 Query: 67 SDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRD 126 D D + ++ S D T+++WD T + GH +V F I+SGS D Sbjct: 191 -DYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAVFHPTLPIIISGSED 249 Query: 127 KTIKLWN--TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKL 184 T+K+WN T V K T+ W C+ P I S G+D V +L N + Sbjct: 250 GTLKIWNSSTYKVEK-TLNVGLERSW--CIATHPTGRKNYIAS-GFDNGFTVLSLGNDE- 304 Query: 185 KTNHIGHTGYLNTVTVSPDGSLCASGGKDGQA 216 T+++ P G L SGGK+ A Sbjct: 305 -----------PTLSLDPVGKLVWSGGKNAAA 325 Score = 61.6 bits (148), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 45/158 (28%), Positives = 67/158 (42%), Gaps = 6/158 (3%) Query: 79 LSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVC 138 + GS D +R+++ TG F H + S+A ++SGS D T+KLWN Sbjct: 71 IVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWNWENNW 130 Query: 139 KYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLA----NCKLKTNHIGHTGY 194 E H +V CV F+P + C D+ VKVW+L N L T Y Sbjct: 131 ALEQTFEGHEHFVMCVAFNPKDPSTFASGC-LDRTVKVWSLGQSTPNFTLTTGQERGVNY 189 Query: 195 LNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG 232 ++ + PD + D +WD + TL+G Sbjct: 190 VDYYPL-PDKPYMITASDDLTIKIWDYQTKSCVATLEG 226 Score = 61.6 bits (148), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 59/241 (24%), Positives = 101/241 (41%), Gaps = 19/241 (7%) Query: 78 ALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGV 137 L+ + G + LW+ T R V + F + I+ GS D I+++N Sbjct: 28 VLTTLYSGRVELWNYETQVEVRSIQVTETPVRAGKFIARKNWIIVGSDDFRIRVFN-YNT 86 Query: 138 CKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANC-KLKTNHIGHTGYLN 196 + V E+H +++ + P + P ++S D VK+WN N L+ GH ++ Sbjct: 87 GEKVVDFEAHPDYIRSIAVHP--TKPYVLSGSDDLTVKLWNWENNWALEQTFEGHEHFVM 144 Query: 197 TVTVSP-DGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDI--INALCFSP---NRYWLCA 250 V +P D S ASG D +W L + +TL G +N + + P Y + A Sbjct: 145 CVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQERGVNYVDYYPLPDKPYMITA 204 Query: 251 ATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVW 310 + +IKIWD + K V L+ + + S P + +G D +++W Sbjct: 205 SDDLTIKIWDYQTKSCVATLEGHMSNVSFAVFHPTL---------PIIISGSEDGTLKIW 255 Query: 311 Q 311 Sbjct: 256 N 256 Score = 61.6 bits (148), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 50/209 (23%), Positives = 84/209 (40%), Gaps = 14/209 (6%) Query: 51 NYGIPQRA--LRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTG-TTTRRFVGHTKD 107 NY ++ H ++ + + + LSGS D T++LW+ + F GH Sbjct: 83 NYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWNWENNWALEQTFEGHEHF 142 Query: 108 VLSVAFS-SDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIV 166 V+ VAF+ D SG D+T+K+W+ V+ V + P P ++ Sbjct: 143 VMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQERGVNYVDYYPLPDKPYMI 202 Query: 167 SCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKH 226 + D +K+W+ GH ++ P + SG +DG +W+ + K Sbjct: 203 TASDDLTIKIWDYQTKSCVATLEGHMSNVSFAVFHPTLPIIISGSEDGTLKIWNSSTYKV 262 Query: 227 LYTLDGGDIINALCFSPNRYWLCAATGPS 255 TL+ G R W C AT P+ Sbjct: 263 EKTLNVG---------LERSW-CIATHPT 281 >3MKQ-A nrPDB Length = 814 Score = 70.9 bits (172), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 60/212 (28%), Positives = 92/212 (43%), Gaps = 20/212 (9%) Query: 7 LRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFV 66 L T +GH +V +A P+ P S D+T+ +W L + N+ + RG ++ Sbjct: 132 LEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQERGVNYV- 190 Query: 67 SDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRD 126 D D + ++ S D T+++WD T + GH +V F I+SGS D Sbjct: 191 -DYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAVFHPTLPIIISGSED 249 Query: 127 KTIKLWN--TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKL 184 T+K+WN T V K T+ W C+ P I S G+D V +L N + Sbjct: 250 GTLKIWNSSTYKVEK-TLNVGLERSW--CIATHPTGRKNYIAS-GFDNGFTVLSLGNDE- 304 Query: 185 KTNHIGHTGYLNTVTVSPDGSLCASGGKDGQA 216 T+++ P G L SGGK+ A Sbjct: 305 -----------PTLSLDPVGKLVWSGGKNAAA 325 Score = 61.2 bits (147), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 45/158 (28%), Positives = 67/158 (42%), Gaps = 6/158 (3%) Query: 79 LSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVC 138 + GS D +R+++ TG F H + S+A ++SGS D T+KLWN Sbjct: 71 IVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWNWENNW 130 Query: 139 KYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLA----NCKLKTNHIGHTGY 194 E H +V CV F+P + C D+ VKVW+L N L T Y Sbjct: 131 ALEQTFEGHEHFVMCVAFNPKDPSTFASGC-LDRTVKVWSLGQSTPNFTLTTGQERGVNY 189 Query: 195 LNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG 232 ++ + PD + D +WD + TL+G Sbjct: 190 VDYYPL-PDKPYMITASDDLTIKIWDYQTKSCVATLEG 226 Score = 61.2 bits (147), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 50/209 (23%), Positives = 84/209 (40%), Gaps = 14/209 (6%) Query: 51 NYGIPQRA--LRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTG-TTTRRFVGHTKD 107 NY ++ H ++ + + + LSGS D T++LW+ + F GH Sbjct: 83 NYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWNWENNWALEQTFEGHEHF 142 Query: 108 VLSVAFS-SDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIV 166 V+ VAF+ D SG D+T+K+W+ V+ V + P P ++ Sbjct: 143 VMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQERGVNYVDYYPLPDKPYMI 202 Query: 167 SCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKH 226 + D +K+W+ GH ++ P + SG +DG +W+ + K Sbjct: 203 TASDDLTIKIWDYQTKSCVATLEGHMSNVSFAVFHPTLPIIISGSEDGTLKIWNSSTYKV 262 Query: 227 LYTLDGGDIINALCFSPNRYWLCAATGPS 255 TL+ G R W C AT P+ Sbjct: 263 EKTLNVG---------LERSW-CIATHPT 281 Score = 60.1 bits (144), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 58/240 (24%), Positives = 101/240 (42%), Gaps = 19/240 (7%) Query: 79 LSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVC 138 L+ + G + +W+ T R V + F + I+ GS D I+++N Sbjct: 29 LTTLYSGRVEIWNYETQVEVRSIQVTETPVRAGKFIARKNWIIVGSDDFRIRVFN-YNTG 87 Query: 139 KYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANC-KLKTNHIGHTGYLNT 197 + V E+H +++ + P + P ++S D VK+WN N L+ GH ++ Sbjct: 88 EKVVDFEAHPDYIRSIAVHP--TKPYVLSGSDDLTVKLWNWENNWALEQTFEGHEHFVMC 145 Query: 198 VTVSP-DGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDI--INALCFSP---NRYWLCAA 251 V +P D S ASG D +W L + +TL G +N + + P Y + A+ Sbjct: 146 VAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQERGVNYVDYYPLPDKPYMITAS 205 Query: 252 TGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQ 311 +IKIWD + K V L+ + + S P + +G D +++W Sbjct: 206 DDLTIKIWDYQTKSCVATLEGHMSNVSFAVFHPTLP---------IIISGSEDGTLKIWN 256 >5GAN-H nrPDB Length = 465 Score = 70.9 bits (172), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 70/258 (27%), Positives = 104/258 (40%), Gaps = 46/258 (17%) Query: 7 LRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFV 66 L L H G + I P + ++S + D I ++ + +E + L GH + Sbjct: 210 LTQKLDSHVGKIGAIDWHPDSNNQMISCAEDGLIKNFQYSNEEGGLRLLG-DLVGHERRI 268 Query: 67 SDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRD 126 SDV G+F S S D T RLWD +T GH K V S++F D + SG D Sbjct: 269 SDVKYHPSGKFIGSASHDMTWRLWDASTHQELLLQEGHDKGVFSLSFQCDGSLVCSGGMD 328 Query: 127 KTIKLWNTLGVCK-----------YTV-------------------------QDE----- 145 LW+ K YTV +DE Sbjct: 329 SLSMLWDIRSGSKVMTLAGHSKPIYTVAWSPNGYQVATGGGDGIINVWDIRKRDEGQLNQ 388 Query: 146 --SHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHI-GHTGYLNTVTVSP 202 +H V+ VRFS +VSCG+D L+ V++ ++ LK + GHT + ++ +S Sbjct: 389 ILAHRNIVTQVRFSKEDGGKKLVSCGYDNLINVYS-SDTWLKMGSLAGHTDKIISLDISN 447 Query: 203 DGSLCASGGKDGQAMLWD 220 + SGG D LW+ Sbjct: 448 NSHFLVSGGWDRSIKLWN 465 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 69/254 (27%), Positives = 116/254 (45%), Gaps = 18/254 (7%) Query: 66 VSDVVISSDGQFALSGSWDGTLRLWD-LTTGTTTRRFVGHTKDVLSVAFSSD-NRQIVSG 123 +S V +S+D +GSW G L++ + T T++ H + ++ + D N Q++S Sbjct: 178 ISAVSLSTDDMVVATGSWAGDLQVLNSQTLQPLTQKLDSHVGKIGAIDWHPDSNNQMISC 237 Query: 124 SRDKTIKLW---NTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLA 180 + D IK + N G + H +S V++ P S I S D ++W+ + Sbjct: 238 AEDGLIKNFQYSNEEGGLRLLGDLVGHERRISDVKYHP--SGKFIGSASHDMTWRLWDAS 295 Query: 181 NCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG-GDIINAL 239 + GH + +++ DGSL SGG D +MLWD+ G + TL G I + Sbjct: 296 THQELLLQEGHDKGVFSLSFQCDGSLVCSGGMDSLSMLWDIRSGSKVMTLAGHSKPIYTV 355 Query: 240 CFSPNRYWLCAATGPS-IKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSAD--GQ 296 +SPN Y + G I +WD+ + DE + I A T + +S + G+ Sbjct: 356 AWSPNGYQVATGGGDGIINVWDIRKR---DEGQLNQI----LAHRNIVTQVRFSKEDGGK 408 Query: 297 TLFAGYTDNLVRVW 310 L + DNL+ V+ Sbjct: 409 KLVSCGYDNLINVY 422 Score = 65.1 bits (157), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 51/214 (23%), Positives = 103/214 (48%), Gaps = 16/214 (7%) Query: 105 TKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPI 164 TK + +V+ S+D+ + +GS +++ N+ + T + +SH + + + P+S+N + Sbjct: 175 TKPISAVSLSTDDMVVATGSWAGDLQVLNSQTLQPLTQKLDSHVGKIGAIDWHPDSNNQM 234 Query: 165 IVSCGWDKLVKVWNLAN----CKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWD 220 I SC D L+K + +N +L + +GH ++ V P G S D LWD Sbjct: 235 I-SCAEDGLIKNFQYSNEEGGLRLLGDLVGHERRISDVKYHPSGKFIGSASHDMTWRLWD 293 Query: 221 LNEGKHLYTLDGGDI-INALCFSPNRYWLCAATGPSIK-IWDLEGKIIVDELKQEVISTS 278 + + L +G D + +L F + +C+ S+ +WD+ +V++ + Sbjct: 294 ASTHQELLLQEGHDKGVFSLSFQCDGSLVCSGGMDSLSMLWDIRS-------GSKVMTLA 346 Query: 279 SKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQV 312 ++P ++AWS +G + G D ++ VW + Sbjct: 347 GHSKP--IYTVAWSPNGYQVATGGGDGIINVWDI 378 >5I2T-A nrPDB Length = 742 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 57/267 (21%), Positives = 116/267 (43%), Gaps = 16/267 (5%) Query: 60 RGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQ 119 +GH + + S DG ++ S DG +++WD+T+G F HT V +V F+ + Sbjct: 367 QGHFDSTNSLAYSPDGSRVVTASEDGKIKVWDITSGFCLATFEEHTSSVTAVQFAKRGQV 426 Query: 120 IVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKL-VKVWN 178 + S S D T++ W+ + + + +C+ P S ++ + D + VW+ Sbjct: 427 MFSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVDP--SGEVVCAGSLDNFDIHVWS 484 Query: 179 LANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDL-NEGKHLYTLDGGDIIN 237 + +L GH G ++ ++ S + S+ AS D +W + + + ++ + Sbjct: 485 VQTGQLLDALSGHEGPVSCLSFSQENSVLASASWDKTIRIWSIFGRSQQVEPIEVYSDVL 544 Query: 238 ALCFSPNRYWLCAAT-GPSIKIWDLEGK-----------IIVDELKQEVISTSSKAEPPQ 285 AL P+ + +T I I+++E II Q+ + + Sbjct: 545 ALSMRPDGKEVAVSTLKGQISIFNIEDAKQVGNIDCRKDIISGRFNQDRFTAKNSERSKF 604 Query: 286 CTSLAWSADGQTLFAGYTDNLVRVWQV 312 T++ +S DG + AG +N + ++ V Sbjct: 605 FTTIHYSFDGMAIVAGGNNNSICLYDV 631 Score = 60.8 bits (146), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 56/208 (26%), Positives = 97/208 (46%), Gaps = 16/208 (7%) Query: 66 VSDVVISSDGQ-FALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGS 124 V+ V ++ G+ A S G L +++ + + + GH S+A+S D ++V+ S Sbjct: 330 VNTVSVNQTGEWLAFGSSKLGQLLVYEWQSESYILKQQGHFDSTNSLAYSPDGSRVVTAS 389 Query: 125 RDKTIKLWN-TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCK 183 D IK+W+ T G C T E H+ V+ V+F+ ++ S D V+ W+L + Sbjct: 390 EDGKIKVWDITSGFCLATF--EEHTSSVTAVQFAKRGQ--VMFSSSLDGTVRAWDLIRYR 445 Query: 184 LKTNHIGHTG----YLNTVTVSPDGSLCASGGKDG-QAMLWDLNEGKHLYTLDGGD-IIN 237 N TG N + V P G + +G D +W + G+ L L G + ++ Sbjct: 446 ---NFRTFTGTERIQFNCLAVDPSGEVVCAGSLDNFDIHVWSVQTGQLLDALSGHEGPVS 502 Query: 238 ALCFSPNRYWLCAAT-GPSIKIWDLEGK 264 L FS L +A+ +I+IW + G+ Sbjct: 503 CLSFSQENSVLASASWDKTIRIWSIFGR 530 Score = 55.8 bits (133), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 63/292 (21%), Positives = 117/292 (40%), Gaps = 45/292 (15%) Query: 54 IPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTT---GTTTRRFVGHTKDVLS 110 + R GH ++ + S D +F L+ S D + ++W + + F GH V+ Sbjct: 162 VRHRVHAGHFQDITSLTWSQDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMG 221 Query: 111 VAFSSDNRQIVSGSRDKTIKLWN------------TLGVCKYTVQDESHSEW-------- 150 FS D +I + S+D + +W + K D S W Sbjct: 222 AFFSHDQEKIYTVSKDGAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFF 281 Query: 151 ------VSCVRFSPNSSNPIIVSCGWDK-LVKVWNLANCKLKTNHIGHTGYLNTVTVSPD 203 V CV F P + +++ G+ ++++L + L +NTV+V+ Sbjct: 282 YANQAKVKCVTFHPATR---LLAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTVSVNQT 338 Query: 204 GSLCASG-GKDGQAMLWDLNEGKHLYTLDGG-DIINALCFSPN-RYWLCAATGPSIKIWD 260 G A G K GQ ++++ ++ G D N+L +SP+ + A+ IK+WD Sbjct: 339 GEWLAFGSSKLGQLLVYEWQSESYILKQQGHFDSTNSLAYSPDGSRVVTASEDGKIKVWD 398 Query: 261 LEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQV 312 + + ++ S T++ ++ GQ +F+ D VR W + Sbjct: 399 ITSGFCLATFEEHTSS---------VTAVQFAKRGQVMFSSSLDGTVRAWDL 441 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 70/327 (21%), Positives = 119/327 (36%), Gaps = 64/327 (19%) Query: 30 MILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRL 89 IL+ S+D + +W + +E N + GH +V S D + + S DG + + Sbjct: 185 FILTTSKDLSAKIWSVDSEEKN--LAATTFNGHRDYVMGAFFSHDQEKIYTVSKDGAVFV 242 Query: 90 WDLTTG---------------------------TTTRRFVGHTKDVLSVAFSSDNRQIVS 122 W+ T T F + V V F R + Sbjct: 243 WEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQAKVKCVTFHPATRLLAV 302 Query: 123 GSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIV-------SCGWDK--- 172 G +L++ + +T+ + + N N + V + G K Sbjct: 303 GFTSGEFRLYD---LPDFTL--------IQQLSMGQNPVNTVSVNQTGEWLAFGSSKLGQ 351 Query: 173 -LVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLD 231 LV W + LK GH N++ SPDGS + +DG+ +WD+ G L T + Sbjct: 352 LLVYEWQSESYILKQQ--GHFDSTNSLAYSPDGSRVVTASEDGKIKVWDITSGFCLATFE 409 Query: 232 GG-DIINALCFSPN-RYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSL 289 + A+ F+ + ++ +++ WDL ++ T + E Q L Sbjct: 410 EHTSSVTAVQFAKRGQVMFSSSLDGTVRAWDL--------IRYRNFRTFTGTERIQFNCL 461 Query: 290 AWSADGQTLFAGYTDNL-VRVWQVTIG 315 A G+ + AG DN + VW V G Sbjct: 462 AVDPSGEVVCAGSLDNFDIHVWSVQTG 488 Score = 51.2 bits (121), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 70/290 (24%), Positives = 110/290 (37%), Gaps = 53/290 (18%) Query: 67 SDVVISSDGQ-FAL-SGSWDGTLRLWDLTTGTTTRRFV---------GHTKDVLSVAFSS 115 S V S DG+ FAL SG + L++W R+F GH +D+ S+ +S Sbjct: 125 SAVKFSPDGRLFALASGRF---LQIWKTPDVNKDRQFAPFVRHRVHAGHFQDITSLTWSQ 181 Query: 116 DNRQIVSGSRDKTIKLWNTLGVCKYTVQD--ESHSEWVSCVRFSPNSSNPIIVSCGWDKL 173 D+R I++ S+D + K+W+ K H ++V FS + I + D Sbjct: 182 DSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGAFFSHDQEK--IYTVSKDGA 239 Query: 174 VKVWNLAN-----------CKLKTNHIG-----------HTGYLNT-----VTVSPDGSL 206 V VW K + H Y N VT P L Sbjct: 240 VFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQAKVKCVTFHPATRL 299 Query: 207 CASGGKDGQAMLWDLNEGKHLYTLD-GGDIINALCFSPNRYWLCAATGPSIKIWDLEGKI 265 A G G+ L+DL + + L G + +N + + WL + G++ Sbjct: 300 LAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTVSVNQTGEWLAFGSSKL-------GQL 352 Query: 266 IVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIG 315 +V E + E + SLA+S DG + D ++VW +T G Sbjct: 353 LVYEWQSESYILKQQGHFDSTNSLAYSPDGSRVVTASEDGKIKVWDITSG 402 Score = 45.8 bits (107), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 33/139 (23%), Positives = 58/139 (41%) Query: 174 VKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGG 233 V V++L N K T H + + ++ G+L S +DG+A+L + L+ + Sbjct: 62 VSVFDLINNKSFTFEYEHRKNIAAIDLNKQGTLLISIDEDGRAILVNFKARNVLHHFNFK 121 Query: 234 DIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSA 293 + +A+ FSP+ A+G ++IW + V TSL WS Sbjct: 122 EKCSAVKFSPDGRLFALASGRFLQIWKTPDVNKDRQFAPFVRHRVHAGHFQDITSLTWSQ 181 Query: 294 DGQTLFAGYTDNLVRVWQV 312 D + + D ++W V Sbjct: 182 DSRFILTTSKDLSAKIWSV 200 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 48/250 (19%), Positives = 96/250 (38%), Gaps = 39/250 (15%) Query: 58 ALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDN 117 AL GH VS + S + S SWD T+R+W + + + DVL+++ D Sbjct: 493 ALSGHEGPVSCLSFSQENSVLASASWDKTIRIWSIFGRSQQVEPIEVYSDVLALSMRPDG 552 Query: 118 RQIVSGSRDKTIKLWNT-------------------LGVCKYTVQDESHSEWVSCVRFSP 158 +++ + I ++N ++T ++ S++ + + +S Sbjct: 553 KEVAVSTLKGQISIFNIEDAKQVGNIDCRKDIISGRFNQDRFTAKNSERSKFFTTIHYSF 612 Query: 159 NSSNPIIVSCGWDKLVKVWNLANCKLKTNHI--------GHTGYLNTVTVSPDGSLCASG 210 + IV+ G + + ++++ N L I G +LN+ ++ GSL Sbjct: 613 DGM--AIVAGGNNNSICLYDVPNEVLLKRFIVSRNMALNGTLEFLNSKKMTEAGSLDLID 670 Query: 211 GKDGQAMLWDLNEGKHLYTLDGGDI----------INALCFSPNRYWLCAATGPSIKIWD 260 + L D + + GGD+ + ++ FSP AA+ + I+ Sbjct: 671 DAGENSDLEDRIDNSLPGSQRGGDLSTRKMRPEVRVTSVQFSPTANAFAAASTEGLLIYS 730 Query: 261 LEGKIIVDEL 270 I+ D Sbjct: 731 TNDTILFDPF 740 Score = 28.5 bits (62), Expect = 4.2, Method: Compositional matrix adjust. Identities = 33/170 (19%), Positives = 68/170 (40%), Gaps = 16/170 (9%) Query: 68 DVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDK 127 ++ S DG+ LS + + ++DL + H K++ ++ + ++S D Sbjct: 44 NITFSDDGKQLLSPVGN-RVSVFDLINNKSFTFEYEHRKNIAAIDLNKQGTLLISIDEDG 102 Query: 128 TIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTN 187 L N + + + E S V+FSP+ + + + +++W + Sbjct: 103 RAILVNF--KARNVLHHFNFKEKCSAVKFSPDGR---LFALASGRFLQIWKTPDVNKDRQ 157 Query: 188 ---------HIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLN-EGKHL 227 H GH + ++T S D + KD A +W ++ E K+L Sbjct: 158 FAPFVRHRVHAGHFQDITSLTWSQDSRFILTTSKDLSAKIWSVDSEEKNL 207 >5WLC-LO nrPDB Length = 923 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 57/267 (21%), Positives = 116/267 (43%), Gaps = 16/267 (5%) Query: 60 RGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQ 119 +GH + + S DG ++ S DG +++WD+T+G F HT V +V F+ + Sbjct: 342 QGHFDSTNSLAYSPDGSRVVTASEDGKIKVWDITSGFCLATFEEHTSSVTAVQFAKRGQV 401 Query: 120 IVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKL-VKVWN 178 + S S D T++ W+ + + + +C+ P S ++ + D + VW+ Sbjct: 402 MFSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVDP--SGEVVCAGSLDNFDIHVWS 459 Query: 179 LANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDL-NEGKHLYTLDGGDIIN 237 + +L GH G ++ ++ S + S+ AS D +W + + + ++ + Sbjct: 460 VQTGQLLDALSGHEGPVSCLSFSQENSVLASASWDKTIRIWSIFGRSQQVEPIEVYSDVL 519 Query: 238 ALCFSPNRYWLCAAT-GPSIKIWDLEGK-----------IIVDELKQEVISTSSKAEPPQ 285 AL P+ + +T I I+++E II Q+ + + Sbjct: 520 ALSMRPDGKEVAVSTLKGQISIFNIEDAKQVGNIDCRKDIISGRFNQDRFTAKNSERSKF 579 Query: 286 CTSLAWSADGQTLFAGYTDNLVRVWQV 312 T++ +S DG + AG +N + ++ V Sbjct: 580 FTTIHYSFDGMAIVAGGNNNSICLYDV 606 Score = 60.8 bits (146), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 56/208 (26%), Positives = 97/208 (46%), Gaps = 16/208 (7%) Query: 66 VSDVVISSDGQ-FALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGS 124 V+ V ++ G+ A S G L +++ + + + GH S+A+S D ++V+ S Sbjct: 305 VNTVSVNQTGEWLAFGSSKLGQLLVYEWQSESYILKQQGHFDSTNSLAYSPDGSRVVTAS 364 Query: 125 RDKTIKLWN-TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCK 183 D IK+W+ T G C T E H+ V+ V+F+ ++ S D V+ W+L + Sbjct: 365 EDGKIKVWDITSGFCLATF--EEHTSSVTAVQFAKRGQ--VMFSSSLDGTVRAWDLIRYR 420 Query: 184 LKTNHIGHTG----YLNTVTVSPDGSLCASGGKDG-QAMLWDLNEGKHLYTLDGGD-IIN 237 N TG N + V P G + +G D +W + G+ L L G + ++ Sbjct: 421 ---NFRTFTGTERIQFNCLAVDPSGEVVCAGSLDNFDIHVWSVQTGQLLDALSGHEGPVS 477 Query: 238 ALCFSPNRYWLCAAT-GPSIKIWDLEGK 264 L FS L +A+ +I+IW + G+ Sbjct: 478 CLSFSQENSVLASASWDKTIRIWSIFGR 505 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 65/292 (22%), Positives = 119/292 (40%), Gaps = 45/292 (15%) Query: 54 IPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTT---GTTTRRFVGHTKDVLS 110 + R GH ++ + S D +F L+ S D + ++W + + F GH V+ Sbjct: 137 VRHRVHAGHFQDITSLTWSQDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMG 196 Query: 111 VAFSSDNRQIVSGSRDKTIKLWN------------TLGVCKYTVQDESHSEW-------- 150 FS D +I + S+D + +W + K D S W Sbjct: 197 AFFSHDQEKIYTVSKDGAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFF 256 Query: 151 ------VSCVRFSPNSSNPIIVSCGWDK-LVKVWNLANCKLKTNHIGHTGYLNTVTVSPD 203 V CV F P + +++ G+ ++++L + L +NTV+V+ Sbjct: 257 YANQAKVKCVTFHPATR---LLAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTVSVNQT 313 Query: 204 GSLCASG-GKDGQAMLWDLNEGKHLYTLDGG-DIINALCFSPN-RYWLCAATGPSIKIWD 260 G A G K GQ ++++ ++ G D N+L +SP+ + A+ IK+WD Sbjct: 314 GEWLAFGSSKLGQLLVYEWQSESYILKQQGHFDSTNSLAYSPDGSRVVTASEDGKIKVWD 373 Query: 261 LEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQV 312 + + ++ TSS T++ ++ GQ +F+ D VR W + Sbjct: 374 ITSGFCLATFEEH---TSS------VTAVQFAKRGQVMFSSSLDGTVRAWDL 416 Score = 52.0 bits (123), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 70/327 (21%), Positives = 119/327 (36%), Gaps = 64/327 (19%) Query: 30 MILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRL 89 IL+ S+D + +W + +E N + GH +V S D + + S DG + + Sbjct: 160 FILTTSKDLSAKIWSVDSEEKN--LAATTFNGHRDYVMGAFFSHDQEKIYTVSKDGAVFV 217 Query: 90 WDLTTG---------------------------TTTRRFVGHTKDVLSVAFSSDNRQIVS 122 W+ T T F + V V F R + Sbjct: 218 WEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQAKVKCVTFHPATRLLAV 277 Query: 123 GSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIV-------SCGWDK--- 172 G +L++ + +T+ + + N N + V + G K Sbjct: 278 GFTSGEFRLYD---LPDFTL--------IQQLSMGQNPVNTVSVNQTGEWLAFGSSKLGQ 326 Query: 173 -LVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLD 231 LV W + LK GH N++ SPDGS + +DG+ +WD+ G L T + Sbjct: 327 LLVYEWQSESYILKQQ--GHFDSTNSLAYSPDGSRVVTASEDGKIKVWDITSGFCLATFE 384 Query: 232 GG-DIINALCFSPN-RYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSL 289 + A+ F+ + ++ +++ WDL ++ T + E Q L Sbjct: 385 EHTSSVTAVQFAKRGQVMFSSSLDGTVRAWDL--------IRYRNFRTFTGTERIQFNCL 436 Query: 290 AWSADGQTLFAGYTDNL-VRVWQVTIG 315 A G+ + AG DN + VW V G Sbjct: 437 AVDPSGEVVCAGSLDNFDIHVWSVQTG 463 Score = 51.2 bits (121), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 70/290 (24%), Positives = 110/290 (37%), Gaps = 53/290 (18%) Query: 67 SDVVISSDGQ-FAL-SGSWDGTLRLWDLTTGTTTRRFV---------GHTKDVLSVAFSS 115 S V S DG+ FAL SG + L++W R+F GH +D+ S+ +S Sbjct: 100 SAVKFSPDGRLFALASGRF---LQIWKTPDVNKDRQFAPFVRHRVHAGHFQDITSLTWSQ 156 Query: 116 DNRQIVSGSRDKTIKLWNTLGVCKYTVQD--ESHSEWVSCVRFSPNSSNPIIVSCGWDKL 173 D+R I++ S+D + K+W+ K H ++V FS + I + D Sbjct: 157 DSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGAFFSHDQEK--IYTVSKDGA 214 Query: 174 VKVWNLAN-----------CKLKTNHIG-----------HTGYLNT-----VTVSPDGSL 206 V VW K + H Y N VT P L Sbjct: 215 VFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQAKVKCVTFHPATRL 274 Query: 207 CASGGKDGQAMLWDLNEGKHLYTLD-GGDIINALCFSPNRYWLCAATGPSIKIWDLEGKI 265 A G G+ L+DL + + L G + +N + + WL + G++ Sbjct: 275 LAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTVSVNQTGEWLAFGSSKL-------GQL 327 Query: 266 IVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIG 315 +V E + E + SLA+S DG + D ++VW +T G Sbjct: 328 LVYEWQSESYILKQQGHFDSTNSLAYSPDGSRVVTASEDGKIKVWDITSG 377 Score = 45.4 bits (106), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 33/139 (23%), Positives = 58/139 (41%) Query: 174 VKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGG 233 V V++L N K T H + + ++ G+L S +DG+A+L + L+ + Sbjct: 37 VSVFDLINNKSFTFEYEHRKNIAAIDLNKQGTLLISIDEDGRAILVNFKARNVLHHFNFK 96 Query: 234 DIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSA 293 + +A+ FSP+ A+G ++IW + V TSL WS Sbjct: 97 EKCSAVKFSPDGRLFALASGRFLQIWKTPDVNKDRQFAPFVRHRVHAGHFQDITSLTWSQ 156 Query: 294 DGQTLFAGYTDNLVRVWQV 312 D + + D ++W V Sbjct: 157 DSRFILTTSKDLSAKIWSV 175 Score = 41.6 bits (96), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 49/254 (19%), Positives = 98/254 (38%), Gaps = 39/254 (15%) Query: 58 ALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDN 117 AL GH VS + S + S SWD T+R+W + + + DVL+++ D Sbjct: 468 ALSGHEGPVSCLSFSQENSVLASASWDKTIRIWSIFGRSQQVEPIEVYSDVLALSMRPDG 527 Query: 118 RQIVSGSRDKTIKLWNT-------------------LGVCKYTVQDESHSEWVSCVRFSP 158 +++ + I ++N ++T ++ S++ + + +S Sbjct: 528 KEVAVSTLKGQISIFNIEDAKQVGNIDCRKDIISGRFNQDRFTAKNSERSKFFTTIHYSF 587 Query: 159 NSSNPIIVSCGWDKLVKVWNLANCKLKTNHI--------GHTGYLNTVTVSPDGSLCASG 210 + IV+ G + + ++++ N L I G +LN+ ++ GSL Sbjct: 588 DGM--AIVAGGNNNSICLYDVPNEVLLKRFIVSRNMALNGTLEFLNSKKMTEAGSLDLID 645 Query: 211 GKDGQAMLWDLNEGKHLYTLDGGDI----------INALCFSPNRYWLCAATGPSIKIWD 260 + L D + + GGD+ + ++ FSP AA+ + I+ Sbjct: 646 DAGENSDLEDRIDNSLPGSQRGGDLSTRKMRPEVRVTSVQFSPTANAFAAASTEGLLIYS 705 Query: 261 LEGKIIVDELKQEV 274 I+ D +V Sbjct: 706 TNDTILFDPFDLDV 719 Score = 28.9 bits (63), Expect = 3.4, Method: Compositional matrix adjust. Identities = 33/170 (19%), Positives = 68/170 (40%), Gaps = 16/170 (9%) Query: 68 DVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDK 127 ++ S DG+ LS + + ++DL + H K++ ++ + ++S D Sbjct: 19 NITFSDDGKQLLSPVGN-RVSVFDLINNKSFTFEYEHRKNIAAIDLNKQGTLLISIDEDG 77 Query: 128 TIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTN 187 L N + + + E S V+FSP+ + + + +++W + Sbjct: 78 RAILVNF--KARNVLHHFNFKEKCSAVKFSPDGR---LFALASGRFLQIWKTPDVNKDRQ 132 Query: 188 ---------HIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLN-EGKHL 227 H GH + ++T S D + KD A +W ++ E K+L Sbjct: 133 FAPFVRHRVHAGHFQDITSLTWSQDSRFILTTSKDLSAKIWSVDSEEKNL 182 >3CFV-B nrPDB Length = 414 Score = 69.3 bits (168), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 77/292 (26%), Positives = 130/292 (44%), Gaps = 36/292 (12%) Query: 13 GHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTR-----DETNYGIPQRALRGHSHFVS 67 H G V + PQ P +I + + ++++ T+ D + P LRGH Sbjct: 124 NHEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGY 183 Query: 68 DVVISSD-GQFALSGSWDGTLRLWDLTTGTTTRR-------FVGHTKDVLSVAFSSDNRQ 119 + +S+ LS S D T+ LWD+ G + F GH+ V VA+ + Sbjct: 184 GLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHES 243 Query: 120 IV-SGSRDKTIKLWNTLG--VCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKV 176 + S + D+ + +W+T K + ++H+ V+C+ F+P S I+ + DK V + Sbjct: 244 LFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEF-ILATGSADKTVAL 302 Query: 177 WNLANCKLKTNHI-GHTGYLNTVTVSP-DGSLCASGGKDGQAMLWDLNE-GKHLYTLDGG 233 W+L N KLK + H + V SP + ++ AS G D + +WDL++ G+ D Sbjct: 303 WDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAE 362 Query: 234 DIINALCF--------------SPNRYW-LCAATGPSI-KIWDLEGKIIVDE 269 D L F +PN W +C+ + +I +IW + I DE Sbjct: 363 DGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMAENIYNDE 414 >6GMH-W nrPDB Length = 305 Score = 69.3 bits (168), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 50/205 (24%), Positives = 96/205 (46%), Gaps = 8/205 (3%) Query: 29 DMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLR 88 + +++ S D + +WK + + Q +L GH V V IS A S S D +R Sbjct: 33 ETVVTGSLDDLVKVWKWRDERLDL---QWSLEGHQLGVVSVDISHTLPIAASSSLDAHIR 89 Query: 89 LWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTL-GVCKYTVQDESH 147 LWDL G + D ++AFS D++ + +G+ + ++ G +Y++ ++ Sbjct: 90 LWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSL--DTR 147 Query: 148 SEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLC 207 +++ + +SP+ + S D ++ ++++A KL GH + ++T SPD L Sbjct: 148 GKFILSIAYSPDGK--YLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLL 205 Query: 208 ASGGKDGQAMLWDLNEGKHLYTLDG 232 + DG ++D+ TL G Sbjct: 206 VTASDDGYIKIYDVQHANLAGTLSG 230 Score = 60.8 bits (146), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 50/219 (22%), Positives = 100/219 (45%), Gaps = 9/219 (4%) Query: 3 EQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGH 62 E++ L+ +L+GH V + + P + S+S D I +W L + I + Sbjct: 52 ERLDLQWSLEGHQLGVVSVDISHTLP-IAASSSLDAHIRLWDLENGKQIKSIDAGPVDAW 110 Query: 63 SHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVS 122 + + S D Q+ +G+ G + ++ + +G K +LS+A+S D + + S Sbjct: 111 T-----LAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLAS 165 Query: 123 GSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANC 182 G+ D I +++ + K E H+ + + FSP+S ++V+ D +K++++ + Sbjct: 166 GAIDGIINIFD-IATGKLLHTLEGHAMPIRSLTFSPDSQ--LLVTASDDGYIKIYDVQHA 222 Query: 183 KLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDL 221 L GH ++ V PD + S D +WD+ Sbjct: 223 NLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDV 261 Score = 55.5 bits (132), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 46/168 (27%), Positives = 79/168 (47%), Gaps = 3/168 (1%) Query: 53 GIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVA 112 G + +L F+ + S DG++ SG+ DG + ++D+ TG GH + S+ Sbjct: 138 GKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLT 197 Query: 113 FSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDK 172 FS D++ +V+ S D IK+++ + H+ WV V F P+ ++ VS DK Sbjct: 198 FSPDSQLLVTASDDGYIKIYD-VQHANLAGTLSGHASWVLNVAFCPDDTH--FVSSSSDK 254 Query: 173 LVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWD 220 VKVW++ H + V + +GS S G D + ++D Sbjct: 255 SVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302 Score = 54.7 bits (130), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 55/225 (24%), Positives = 100/225 (44%), Gaps = 18/225 (8%) Query: 95 GTTTRRFVGHTKDVLSVAFSSDNRQ----IVSGSRDKTIKLWNTLGVCKYTVQDESHSEW 150 G ++ H + SVA+ ++ ++ +V+GS D +K+W + +Q Sbjct: 6 GILFKQEQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDE-RLDLQWSLEGHQ 64 Query: 151 VSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCK-LKTNHIGHTGYLNTVTVSPDGSLCAS 209 + V + + PI S D +++W+L N K +K+ G T+ SPD A+ Sbjct: 65 LGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAW-TLAFSPDSQYLAT 123 Query: 210 GGKDGQAMLWDLNEGKHLYTLDG-GDIINALCFSPN-RYWLCAATGPSIKIWDLEGKIIV 267 G G+ ++ + GK Y+LD G I ++ +SP+ +Y A I I+D+ ++ Sbjct: 124 GTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLL 183 Query: 268 DELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQV 312 L+ A P SL +S D Q L D ++++ V Sbjct: 184 HTLE-------GHAMP--IRSLTFSPDSQLLVTASDDGYIKIYDV 219 >6EOJ-D nrPDB Length = 470 Score = 68.6 bits (166), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 44/162 (27%), Positives = 76/162 (46%), Gaps = 5/162 (3%) Query: 64 HFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSG 123 H + + + +G+ + ++ G LW+ ++ T H V ++ +S D+ ++SG Sbjct: 94 HVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISG 153 Query: 124 SRDKTIKLWN-TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANC 182 D IK+W + K D +H+E + + FS N S V+C D ++K+WN +N Sbjct: 154 DADGMIKIWQPNFSMVKEI--DAAHTESIRDMAFSSNDSK--FVTCSDDNILKIWNFSNG 209 Query: 183 KLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEG 224 K + GH + + P+ L AS KD LWD G Sbjct: 210 KQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSG 251 Score = 58.9 bits (141), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 64/257 (24%), Positives = 103/257 (40%), Gaps = 15/257 (5%) Query: 59 LRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNR 118 ++ H V+ + S D + +SG DG +++W HT+ + +AFSS++ Sbjct: 131 MQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDS 190 Query: 119 QIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWN 178 + V+ S D +K+WN + V H + SC + P +I S D LVK+W+ Sbjct: 191 KFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSC-DWHPEMG--LIASASKDNLVKLWD 247 Query: 179 L--ANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEG-KHLYTLDGGDI 235 NC HT L T G+L + KD ++D+ K L + Sbjct: 248 PRSGNCISSILKFKHT-VLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETD 306 Query: 236 INALCFSP--NRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSA 293 L + P + A S+K +DL + E I T A TSL+++ Sbjct: 307 YMTLEWHPINESMFTLACYDGSLKHFDLLQNL------NEPILTIPYAHDKCITSLSYNP 360 Query: 294 DGQTLFAGYTDNLVRVW 310 G D +R W Sbjct: 361 VGHIFATAAKDRTIRFW 377 Score = 57.0 bits (136), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 59/262 (22%), Positives = 110/262 (41%), Gaps = 16/262 (6%) Query: 5 MTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSH 64 T ++ H+ VT + + D ++S D I +W + N+ + + H+ Sbjct: 125 FTFETLMQAHDSAVTTMKYS-HDSDWMISGDADGMIKIW-----QPNFSMVKEIDAAHTE 178 Query: 65 FVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGS 124 + D+ SS+ ++ S D L++W+ + G R GH DV S + + I S S Sbjct: 179 SIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASAS 238 Query: 125 RDKTIKLWNTL-GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCK 183 +D +KLW+ G C ++ H+ V RF P N ++++ DK +V+++ Sbjct: 239 KDNLVKLWDPRSGNCISSILKFKHT--VLKTRFQPTKGN-LLMAISKDKSCRVFDIRYSM 295 Query: 184 LKTNHI-GHTGYL----NTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINA 238 + + T Y+ + + S C G +L +LNE I + Sbjct: 296 KELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITS 355 Query: 239 LCFSP-NRYWLCAATGPSIKIW 259 L ++P + AA +I+ W Sbjct: 356 LSYNPVGHIFATAAKDRTIRFW 377 >3JB9-g nrPDB Length = 558 Score = 67.4 bits (163), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 47/175 (26%), Positives = 84/175 (48%), Gaps = 12/175 (6%) Query: 54 IPQRAL---RGHSHFVSDV-VISSDGQFALSGSWDGTLRLWDLTTGTTT-RRFVGHTKDV 108 IP++ + +GH+ +S + G LSGS D +++W++ + R F GH + + Sbjct: 254 IPKKHIFTWKGHTKGISCLRFFPISGHLLLSGSMDNQIKIWEVYHDRSLLRTFQGHARPI 313 Query: 109 LSVAFSSDNRQIVSGSRDKTIKLWNT-LGVCKYTVQDESHSEWVSCVRFS--PNSSNPII 165 ++FS D R +S S DKTIKLW+T LG C + +CV+F P+ N + Sbjct: 314 RDLSFSQDGRSFLSTSFDKTIKLWDTELGKCLNCFNSD---RLTNCVKFQVDPDKPNEFL 370 Query: 166 VSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWD 220 DK + +++ + + + H G +N++T +G + D W+ Sbjct: 371 AGTA-DKRILQFDIRSPDIVQAYDHHLGGINSITFLENGKRFVTTSDDSSMRFWE 424 Score = 62.8 bits (151), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 74/313 (23%), Positives = 114/313 (36%), Gaps = 77/313 (24%) Query: 10 TLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDV 69 T KGH ++ + P ++LS S D I +W++ D + R +GH+ + D+ Sbjct: 261 TWKGHTKGISCLRFFPISGHLLLSGSMDNQIKIWEVYHDRSLL----RTFQGHARPIRDL 316 Query: 70 VISSDGQFALSGSWDGTLRLWD------------------------------LTTGTTTR 99 S DG+ LS S+D T++LWD GT + Sbjct: 317 SFSQDGRSFLSTSFDKTIKLWDTELGKCLNCFNSDRLTNCVKFQVDPDKPNEFLAGTADK 376 Query: 100 RFVG--------------HTKDVLSVAFSSDNRQIVSGSRDKTIKLWN--TLGVCKYTVQ 143 R + H + S+ F + ++ V+ S D +++ W T K+ Sbjct: 377 RILQFDIRSPDIVQAYDHHLGGINSITFLENGKRFVTTSDDSSMRFWEYGTPVPIKFVAD 436 Query: 144 DESHSEWVSCVRFSPNSS--------NPIIVSCGWDKL----VKVWNLANCKLKTNHIGH 191 HS + V PN N I V ++K KV+ +C Sbjct: 437 IAMHS--MPRVALRPNGKSIACQSLDNCIYVYSAYEKYRQNKKKVFKGYSC--------- 485 Query: 192 TGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG-GDIINALCFSPNRYWLCA 250 +GY V SPDG SG G A WD K + L + ++ F P A Sbjct: 486 SGYSLEVGFSPDGRFVFSGDSSGNACFWDWKTCKLMAKLPAHSGPVQSMAFHPQETSKVA 545 Query: 251 ATG---PSIKIWD 260 + SIK WD Sbjct: 546 TSSIVDGSIKYWD 558 Score = 33.5 bits (75), Expect = 0.11, Method: Compositional matrix adjust. Identities = 28/89 (31%), Positives = 41/89 (46%), Gaps = 8/89 (8%) Query: 182 CKLKTNHI----GHTGYLNTVTVSP-DGSLCASGGKDGQAMLWDLNEGKHLY-TLDG-GD 234 C + HI GHT ++ + P G L SG D Q +W++ + L T G Sbjct: 252 CYIPKKHIFTWKGHTKGISCLRFFPISGHLLLSGSMDNQIKIWEVYHDRSLLRTFQGHAR 311 Query: 235 IINALCFSPN-RYWLCAATGPSIKIWDLE 262 I L FS + R +L + +IK+WD E Sbjct: 312 PIRDLSFSQDGRSFLSTSFDKTIKLWDTE 340 >6N9G-C nrPDB Length = 353 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 64/273 (23%), Positives = 124/273 (45%), Gaps = 22/273 (8%) Query: 56 QRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSS 115 +R L+GH + V + D + +S S DG + +WD T V++ A++ Sbjct: 56 RRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAP 115 Query: 116 DNRQIVSGSRDKTIKLW-------NTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSC 168 I G D ++ + K +V H+ ++S F+ NS I+ + Sbjct: 116 SGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVA--MHTNYLSACSFT-NSDMQILTAS 172 Query: 169 GWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPD--GSLCASGGKDGQAMLWDLNEGKH 226 G D +W++ + +L + GH + + ++P G+ SGG D +AM+WD+ G+ Sbjct: 173 G-DGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQC 231 Query: 227 LYTLDGGDI-INALCFSPN-RYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPP 284 + + + +N++ + P+ + + + +++DL +EV S ++ Sbjct: 232 VQAFETHESDVNSVRYYPSGDAFASGSDDATCRLYDLRAD-------REVAIYSKESIIF 284 Query: 285 QCTSLAWSADGQTLFAGYTDNLVRVWQVTIGTR 317 +S+ +S G+ LFAGY D + VW V G+R Sbjct: 285 GASSVDFSLSGRLLFAGYNDYTINVWDVLKGSR 317 Score = 64.7 bits (156), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 77/318 (24%), Positives = 128/318 (40%), Gaps = 30/318 (9%) Query: 5 MTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWK--LTRDETNYGIPQRALRGH 62 M R TLKGH V + I+S+S+D +I+W T E +P + Sbjct: 53 MKTRRTLKGHGNKVLCMDWCKD-KRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMAC 111 Query: 63 SHFVSDVVISSDGQFALSGSWDGTLRLWDLT------TGTTTRRFVGHTKDVLSVAFSSD 116 ++ S I+ G D ++ LT + HT + + +F++ Sbjct: 112 AYAPSGCAIAC-------GGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNS 164 Query: 117 NRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKV 176 + QI++ S D T LW+ + + H V C+ +P+ + VS G DK V Sbjct: 165 DMQILTASGDGTCALWD-VESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMV 223 Query: 177 WNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDII 236 W++ + + H +N+V P G ASG D L+DL + + II Sbjct: 224 WDMRSGQCVQAFETHESDVNSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESII 283 Query: 237 ---NALCFS-PNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWS 292 +++ FS R +I +WD+ LK +S E + ++L S Sbjct: 284 FGASSVDFSLSGRLLFAGYNDYTINVWDV--------LKGSRVSILFGHE-NRVSTLRVS 334 Query: 293 ADGQTLFAGYTDNLVRVW 310 DG +G D+ +RVW Sbjct: 335 PDGTAFCSGSWDHTLRVW 352 >6QDV-o nrPDB Length = 513 Score = 65.9 bits (159), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 73/266 (27%), Positives = 115/266 (43%), Gaps = 33/266 (12%) Query: 13 GHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALR---GHSHFVSDV 69 GH V+ + P ++LS S D I +W++ YG +R LR GHS V D+ Sbjct: 220 GHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEV------YG-ERRCLRTFIGHSKAVRDI 272 Query: 70 VISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQ---IVSGSRD 126 ++ G LS ++D L+LWD TG RF K V F+ D + V+G D Sbjct: 273 CFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNR-KVPYCVKFNPDEDKQNLFVAGMSD 331 Query: 127 KTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKT 186 K I W+ + + + + H V+ + F N VS DK ++VW + + Sbjct: 332 KKIVQWD-IRSGEIVQEYDRHLGAVNTIVFV--DENRRFVSTSDDKSLRVWEW-DIPVDF 387 Query: 187 NHIGHTGY--LNTVTVSPDGSLCASGGKDGQAML------WDLNEGKHLYTLDGGDIINA 238 +I + VT+SP+G A D Q ++ + LN+ K G + Sbjct: 388 KYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKK---IFKGHMVAGY 444 Query: 239 LC---FSPNRYWLCAATGP-SIKIWD 260 C FSP+ ++ + G + IWD Sbjct: 445 ACQVDFSPDMSYVISGDGNGKLNIWD 470 Score = 42.4 bits (98), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 36/171 (21%), Positives = 74/171 (43%), Gaps = 17/171 (9%) Query: 147 HSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCK--LKTNHIGHTGYLNTVTVSPDG 204 H++ VS VR P S + +++SC D +K+W + + L+T IGH+ + + + G Sbjct: 221 HTKGVSAVRLFPLSGH-LLLSCSMDCKIKLWEVYGERRCLRT-FIGHSKAVRDICFNTAG 278 Query: 205 SLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNR----YWLCAATGPSIKIWD 260 + S D LWD G+ + + + F+P+ ++ + I WD Sbjct: 279 TQFLSAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPDEDKQNLFVAGMSDKKIVQWD 338 Query: 261 LEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQ 311 + IV E + + + + ++ + + + + D +RVW+ Sbjct: 339 IRSGEIVQEYDRHLGAVN---------TIVFVDENRRFVSTSDDKSLRVWE 380 Score = 37.0 bits (84), Expect = 0.012, Method: Compositional matrix adjust. Identities = 22/81 (27%), Positives = 39/81 (48%), Gaps = 3/81 (3%) Query: 56 QRALRGH--SHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVL-SVA 112 ++ +GH + + V S D + +SG +G L +WD T RF H K + +V Sbjct: 433 KKIFKGHMVAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVW 492 Query: 113 FSSDNRQIVSGSRDKTIKLWN 133 + ++++ D IKLW+ Sbjct: 493 HPHETSKVITCGWDGLIKLWD 513 Score = 34.7 bits (78), Expect = 0.050, Method: Compositional matrix adjust. Identities = 34/156 (21%), Positives = 69/156 (44%), Gaps = 17/156 (10%) Query: 31 ILSASRDKTIIMWKLTRDETNYGIP---QRALRGHSHFVSDVVISSDGQFALSGSWDGTL 87 +S S DK++ +W+ + IP + H + V +S +G++ S D + Sbjct: 367 FVSTSDDKSLRVWE-------WDIPVDFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQI 419 Query: 88 RLWDLTTG---TTTRRFVGH--TKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTV 142 ++ + F GH V FS D ++SG + + +W+ K Sbjct: 420 LIFGAQNRFRLNKKKIFKGHMVAGYACQVDFSPDMSYVISGDGNGKLNIWD-WKTTKLYS 478 Query: 143 QDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWN 178 + ++H + + P+ ++ +I +CGWD L+K+W+ Sbjct: 479 RFKAHDKVCIGAVWHPHETSKVI-TCGWDGLIKLWD 513 >5OQL-J nrPDB Length = 912 Score = 65.9 bits (159), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 57/214 (26%), Positives = 91/214 (42%), Gaps = 22/214 (10%) Query: 28 PDMILSASRDKTIIMWKLTRDETNYGIPQRALR--GHSHFVSDVVISSDGQFALSGSWDG 85 P ++S S+D+ + + R G +LR H ++ + IS +G+ S S D Sbjct: 507 PAFLISGSQDRFVQKRDIPRQLQKGGKLTSSLRRLAHDKDINALDISPNGKLFASASQDK 566 Query: 86 TLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIV--------------SGSRDKTIKL 131 T+++WD+ GH + V +V F+ N ++ +GS DKTIKL Sbjct: 567 TVKIWDVEKLEVQGILRGHKRGVWTVRFAPLNTPVIQGEQGSVSGRGVVLTGSGDKTIKL 626 Query: 132 WNTLG-VCKYTVQDESHSE----WVSCVRFSPNSSNPI-IVSCGWDKLVKVWNLANCKLK 185 WN C T + SH+ W+ R + + S G D LVKVW+ + + Sbjct: 627 WNLSDYTCIRTFEGHSHNVLKVVWLHISRDDSITKTKVQFASAGADTLVKVWDANTGETE 686 Query: 186 TNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLW 219 H L T+ V ++ AS G D + W Sbjct: 687 CTLDNHEDRLWTLAVHSKTNILASAGSDSKVTFW 720 Score = 58.9 bits (141), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 53/185 (28%), Positives = 84/185 (45%), Gaps = 33/185 (17%) Query: 77 FALSGSWDGTLRLWDLTTG-------TTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTI 129 F +SGS D ++ D+ T++ R + H KD+ ++ S + + S S+DKT+ Sbjct: 509 FLISGSQDRFVQKRDIPRQLQKGGKLTSSLRRLAHDKDINALDISPNGKLFASASQDKTV 568 Query: 130 KLWNTLGVCKYTVQD--ESHSEWVSCVRFSP------------NSSNPIIVSCGWDKLVK 175 K+W+ V K VQ H V VRF+P S ++++ DK +K Sbjct: 569 KIWD---VEKLEVQGILRGHKRGVWTVRFAPLNTPVIQGEQGSVSGRGVVLTGSGDKTIK 625 Query: 176 VWNLANCKLKTNHIGHTGYLNTVT---VSPDGSLC------ASGGKDGQAMLWDLNEGKH 226 +WNL++ GH+ + V +S D S+ AS G D +WD N G+ Sbjct: 626 LWNLSDYTCIRTFEGHSHNVLKVVWLHISRDDSITKTKVQFASAGADTLVKVWDANTGET 685 Query: 227 LYTLD 231 TLD Sbjct: 686 ECTLD 690 Score = 45.4 bits (106), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 29/86 (33%), Positives = 48/86 (55%), Gaps = 11/86 (12%) Query: 55 PQRALRGHSHFVSDVVISSDGQFALS-GSWDGTLRLWDLTTGTTT-------RRFVGHTK 106 P++ R + +D + S +F L+ G+ DG +R++DL TTT R+ H Sbjct: 177 PKKGSRKGQNDDADEIAS---RFRLAWGTQDGRIRIFDLYKRTTTPVYADPKRKKEAHES 233 Query: 107 DVLSVAFSSDNRQIVSGSRDKTIKLW 132 +V +A+S + ++SGSRDKT+ LW Sbjct: 234 NVQCIAYSPEQHALLSGSRDKTMTLW 259 Score = 44.7 bits (104), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 51/226 (22%), Positives = 93/226 (41%), Gaps = 42/226 (18%) Query: 47 RDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRR----FV 102 R + +G L+GH V + + G + SGS D T RLW + + F Sbjct: 417 RSGSYFGHDVALLKGHEDIVMSLDVDWSGHWIASGSKDNTARLWRVDPANNSYTCYAVFT 476 Query: 103 GHTKDVLSVAFSS----DNRQ------------IVSGSRDKTIKLWNTL------GVCKY 140 GH + V +VA N + ++SGS+D+ ++ + G Sbjct: 477 GHLESVGAVALPKVVPPANSEAFKNPLDHPPAFLISGSQDRFVQKRDIPRQLQKGGKLTS 536 Query: 141 TVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTV 200 +++ +H + ++ + SPN + S DK VK+W++ +++ GH + TV Sbjct: 537 SLRRLAHDKDINALDISPNGK--LFASASQDKTVKIWDVEKLEVQGILRGHKRGVWTVRF 594 Query: 201 SP---------DGSLCA-----SGGKDGQAMLWDLNEGKHLYTLDG 232 +P GS+ +G D LW+L++ + T +G Sbjct: 595 APLNTPVIQGEQGSVSGRGVVLTGSGDKTIKLWNLSDYTCIRTFEG 640 Score = 34.3 bits (77), Expect = 0.067, Method: Compositional matrix adjust. Identities = 35/144 (24%), Positives = 65/144 (45%), Gaps = 6/144 (4%) Query: 8 RGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETN--YGIPQRALRGHSHF 65 +G+ KG N +IA+ +F + ++D I ++ L + T Y P+R H Sbjct: 179 KGSRKGQNDDADEIAS--RF--RLAWGTQDGRIRIFDLYKRTTTPVYADPKRKKEAHESN 234 Query: 66 VSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSR 125 V + S + LSGS D T+ LW G + + + SV F ++ + + S Sbjct: 235 VQCIAYSPEQHALLSGSRDKTMTLWLWRDGIWQGTPMLRHELLESVGFLNEGKWMYSAGT 294 Query: 126 DKTIKLWNTLGVCKYTVQDESHSE 149 +++W+T + T + ++ SE Sbjct: 295 SGVLRIWDTTTHHEITKKQDAKSE 318 Score = 33.5 bits (75), Expect = 0.12, Method: Compositional matrix adjust. Identities = 48/241 (19%), Positives = 84/241 (34%), Gaps = 55/241 (22%) Query: 57 RALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAF--- 113 R + H+ V + + +G+ DG +++WD+ G T G + V ++ F Sbjct: 105 RTTKPHATPVVVLAVDRTSTLLATGAADGAIKIWDIIGGYVTHTVSGPSVLVSALHFFEI 164 Query: 114 ------SSDNRQIVSGSR---------------------DKTIKLWNTLGVCKYTV---- 142 S N++ GSR D I++++ V Sbjct: 165 AVTAESQSSNKKPKKGSRKGQNDDADEIASRFRLAWGTQDGRIRIFDLYKRTTTPVYADP 224 Query: 143 --QDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWN------LANCKLKTNHIGHTGY 194 + E+H V C+ +SP ++S DK + +W L+ + G+ Sbjct: 225 KRKKEAHESNVQCIAYSPEQH--ALLSGSRDKTMTLWLWRDGIWQGTPMLRHELLESVGF 282 Query: 195 LNTVTVSPDGSLCASGGKDGQAMLWDLN-----EGKHLYTLDGGDIINALCFSPNRYWLC 249 LN +G S G G +WD K +G I++A+ LC Sbjct: 283 LN------EGKWMYSAGTSGVLRIWDTTTHHEITKKQDAKSEGEAILSAVSLPERSLILC 336 Query: 250 A 250 A Sbjct: 337 A 337 Score = 30.0 bits (66), Expect = 1.3, Method: Compositional matrix adjust. Identities = 32/141 (22%), Positives = 59/141 (41%), Gaps = 13/141 (9%) Query: 110 SVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCG 169 SVA + R + S + I L K + + E +S + +P+ S+ I+ C Sbjct: 25 SVALENGARILASTLGENAI--LTELNTGKRLAEIQGDGEPISTLTITPSGSHLIV--CS 80 Query: 170 WDKLVKVWNLA--------NCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDL 221 +++++LA L H + + V +L A+G DG +WD+ Sbjct: 81 RSLTMRIYSLAISPDYDSVEPTLVRTTKPHATPVVVLAVDRTSTLLATGAADGAIKIWDI 140 Query: 222 NEGKHLYTLDGGDI-INALCF 241 G +T+ G + ++AL F Sbjct: 141 IGGYVTHTVSGPSVLVSALHF 161 Score = 29.3 bits (64), Expect = 2.2, Method: Compositional matrix adjust. Identities = 22/96 (22%), Positives = 40/96 (41%), Gaps = 8/96 (8%) Query: 49 ETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTG--------TTTRR 100 E N G ++G +S + I+ G + S T+R++ L T R Sbjct: 47 ELNTGKRLAEIQGDGEPISTLTITPSGSHLIVCSRSLTMRIYSLAISPDYDSVEPTLVRT 106 Query: 101 FVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLG 136 H V+ +A + + +G+ D IK+W+ +G Sbjct: 107 TKPHATPVVVLAVDRTSTLLATGAADGAIKIWDIIG 142 >5YZG-W nrPDB Length = 579 Score = 65.9 bits (159), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 73/266 (27%), Positives = 115/266 (43%), Gaps = 33/266 (12%) Query: 13 GHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALR---GHSHFVSDV 69 GH V+ + P ++LS S D I +W++ YG +R LR GHS V D+ Sbjct: 286 GHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEV------YG-ERRCLRTFIGHSKAVRDI 338 Query: 70 VISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQ---IVSGSRD 126 ++ G LS ++D L+LWD TG RF K V F+ D + V+G D Sbjct: 339 CFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNR-KVPYCVKFNPDEDKQNLFVAGMSD 397 Query: 127 KTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKT 186 K I W+ + + + + H V+ + F N VS DK ++VW + + Sbjct: 398 KKIVQWD-IRSGEIVQEYDRHLGAVNTIVFV--DENRRFVSTSDDKSLRVWEW-DIPVDF 453 Query: 187 NHIGHTGY--LNTVTVSPDGSLCASGGKDGQAML------WDLNEGKHLYTLDGGDIINA 238 +I + VT+SP+G A D Q ++ + LN+ K G + Sbjct: 454 KYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKK---IFKGHMVAGY 510 Query: 239 LC---FSPNRYWLCAATGP-SIKIWD 260 C FSP+ ++ + G + IWD Sbjct: 511 ACQVDFSPDMSYVISGDGNGKLNIWD 536 Score = 42.0 bits (97), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 36/171 (21%), Positives = 74/171 (43%), Gaps = 17/171 (9%) Query: 147 HSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCK--LKTNHIGHTGYLNTVTVSPDG 204 H++ VS VR P S + +++SC D +K+W + + L+T IGH+ + + + G Sbjct: 287 HTKGVSAVRLFPLSGH-LLLSCSMDCKIKLWEVYGERRCLRT-FIGHSKAVRDICFNTAG 344 Query: 205 SLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNR----YWLCAATGPSIKIWD 260 + S D LWD G+ + + + F+P+ ++ + I WD Sbjct: 345 TQFLSAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPDEDKQNLFVAGMSDKKIVQWD 404 Query: 261 LEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQ 311 + IV E + + + + ++ + + + + D +RVW+ Sbjct: 405 IRSGEIVQEYDRHLGAVN---------TIVFVDENRRFVSTSDDKSLRVWE 446 Score = 36.6 bits (83), Expect = 0.013, Method: Compositional matrix adjust. Identities = 22/81 (27%), Positives = 39/81 (48%), Gaps = 3/81 (3%) Query: 56 QRALRGH--SHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVL-SVA 112 ++ +GH + + V S D + +SG +G L +WD T RF H K + +V Sbjct: 499 KKIFKGHMVAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVW 558 Query: 113 FSSDNRQIVSGSRDKTIKLWN 133 + ++++ D IKLW+ Sbjct: 559 HPHETSKVITCGWDGLIKLWD 579 Score = 34.7 bits (78), Expect = 0.059, Method: Compositional matrix adjust. Identities = 34/156 (21%), Positives = 69/156 (44%), Gaps = 17/156 (10%) Query: 31 ILSASRDKTIIMWKLTRDETNYGIP---QRALRGHSHFVSDVVISSDGQFALSGSWDGTL 87 +S S DK++ +W+ + IP + H + V +S +G++ S D + Sbjct: 433 FVSTSDDKSLRVWE-------WDIPVDFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQI 485 Query: 88 RLWDLTTG---TTTRRFVGH--TKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTV 142 ++ + F GH V FS D ++SG + + +W+ K Sbjct: 486 LIFGAQNRFRLNKKKIFKGHMVAGYACQVDFSPDMSYVISGDGNGKLNIWD-WKTTKLYS 544 Query: 143 QDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWN 178 + ++H + + P+ ++ +I +CGWD L+K+W+ Sbjct: 545 RFKAHDKVCIGAVWHPHETSKVI-TCGWDGLIKLWD 579 >1NR0-A nrPDB Length = 611 Score = 65.1 bits (157), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 78/307 (25%), Positives = 135/307 (43%), Gaps = 61/307 (19%) Query: 62 HSHFVSDVVISSDGQFALSGSWDGTLRLWDLTT-----GTTTRRFVGHTKDVLSVAFSSD 116 HSH + S G + SG G +R+WD T TT F G KD+ ++ S+ Sbjct: 58 HSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDI---SWDSE 114 Query: 117 NRQI--VSGSRDK--TIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPI-IVSCGWD 171 +++I V R++ + L++T G + ++ + ++ V F P S P I+S D Sbjct: 115 SKRIAAVGEGRERFGHVFLFDT-GTSNGNLTGQARA--MNSVDFKP--SRPFRIISGSDD 169 Query: 172 KLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLD 231 V ++ K K+ HT ++++V +PDGSL AS G DG +L++ +G + Sbjct: 170 NTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFE 229 Query: 232 GGDIIN--------ALCFSPNRYWLCAATG-PSIKIWDLE----------GKIIVDE--- 269 + N L +SP+ + +A+ +IKIW++ G I D+ Sbjct: 230 DDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLG 289 Query: 270 ---LKQEVISTSSK------------------AEPPQCTSLAWSADGQTLFAGYTDNLVR 308 KQ ++S S+ T+L+ SADG+TLF+ + + Sbjct: 290 IIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHIN 349 Query: 309 VWQVTIG 315 W ++ G Sbjct: 350 SWDISTG 356 Score = 62.0 bits (149), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 61/232 (26%), Positives = 93/232 (40%), Gaps = 26/232 (11%) Query: 6 TLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIP---QRALRGH 62 T G L G + + P P I+S S D T+ +++ G P + H Sbjct: 138 TSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFE--------GPPFKFKSTFGEH 189 Query: 63 SHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRF-------VGHTKDVLSVAFSS 115 + FV V + DG S DGT+ L++ GT T F V H+ V + +S Sbjct: 190 TKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSP 249 Query: 116 DNRQIVSGSRDKTIKLWN--TLGVCK-YTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDK 172 D +I S S DKTIK+WN TL V K V + + + + +VS + Sbjct: 250 DGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIW-----TKQALVSISANG 304 Query: 173 LVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEG 224 + N + GH + ++ S DG S +G WD++ G Sbjct: 305 FINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTG 356 Score = 42.4 bits (98), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 36/159 (22%), Positives = 71/159 (44%), Gaps = 11/159 (6%) Query: 111 VAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGW 170 VA S+D + + G +D + ++ G V+ H ++ V FS N + +V+ Sbjct: 454 VALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGA--FLVATDQ 511 Query: 171 DKLVKVWNLANCKLKTNHIG----HTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNE-GK 225 + V +++AN + H HT + V+ SPD A+G D ++W++N+ Sbjct: 512 SRKVIPYSVAN-NFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSD 570 Query: 226 HLYTLDGGDI---INALCFSPNRYWLCAATGPSIKIWDL 261 H + G +N++ + + A +IK W++ Sbjct: 571 HPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWNV 609 Score = 35.8 bits (81), Expect = 0.028, Method: Compositional matrix adjust. Identities = 62/269 (23%), Positives = 105/269 (39%), Gaps = 42/269 (15%) Query: 61 GHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQI 120 GH+ ++ + S+DG+ S +G + WD++TG + R F +++ ++ + Sbjct: 322 GHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDL 381 Query: 121 VSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPN--SSNPIIVSCGWDKLVKVWN 178 + S D +K+ G V + N SS P+ ++ D + V Sbjct: 382 FTVSWDDHLKVVPAGG------------SGVDSSKAVANKLSSQPLGLAVSADGDIAV-- 427 Query: 179 LANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGK-HLYTLDGGDI-- 235 A C H G L V +S + S C + D Q + + K H+Y L G + Sbjct: 428 -AACYKHIAIYSH-GKLTEVPISYNSS-CVALSNDKQFVAVGGQDSKVHVYKLSGASVSE 484 Query: 236 ---------INALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQ--EVISTSS-KAEP 283 I ++ FS N +L A D K+I + E+ T+S Sbjct: 485 VKTIVHPAEITSVAFSNNGAFLVAT--------DQSRKVIPYSVANNFELAHTNSWTFHT 536 Query: 284 PQCTSLAWSADGQTLFAGYTDNLVRVWQV 312 + ++WS D L G DN V VW + Sbjct: 537 AKVACVSWSPDNVRLATGSLDNSVIVWNM 565 Score = 34.3 bits (77), Expect = 0.064, Method: Compositional matrix adjust. Identities = 62/284 (21%), Positives = 111/284 (39%), Gaps = 35/284 (12%) Query: 28 PD--MILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDG 85 PD I SAS DKTI +W + + IP G + I Q +S S +G Sbjct: 249 PDGTKIASASADKTIKIWNVATLKVEKTIPV----GTRIEDQQLGIIWTKQALVSISANG 304 Query: 86 TLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDE 145 + + G+ + GH K + +++ S+D + + S + I W+ V + Sbjct: 305 FINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPD 364 Query: 146 SHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGS 205 H+ ++ ++ +S + + WD +KV + ++ N ++ P G Sbjct: 365 VHATMITGIK---TTSKGDLFTVSWDDHLKVVPAGGSGVDSSK----AVANKLSSQPLGL 417 Query: 206 LCASGGKDGQAMLWDLNEGKHLYTLDGGDI------INALCFS-PNRYWLCAATG--PSI 256 ++ G A + KH+ G + N+ C + N A G + Sbjct: 418 AVSADGDIAVAACY-----KHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKV 472 Query: 257 KIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFA 300 ++ L G V E+K V P + TS+A+S +G L A Sbjct: 473 HVYKLSGA-SVSEVKTIV-------HPAEITSVAFSNNGAFLVA 508 Score = 31.6 bits (70), Expect = 0.51, Method: Compositional matrix adjust. Identities = 22/76 (28%), Positives = 38/76 (50%), Gaps = 1/76 (1%) Query: 104 HTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNP 163 HT V V++S DN ++ +GS D ++ +WN + + + + +S V + Sbjct: 535 HTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKG-AHAMSSVNSVIWLNET 593 Query: 164 IIVSCGWDKLVKVWNL 179 IVS G D +K WN+ Sbjct: 594 TIVSAGQDSNIKFWNV 609 >5WYK-BB nrPDB Length = 943 Score = 63.9 bits (154), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 50/207 (24%), Positives = 89/207 (42%), Gaps = 16/207 (7%) Query: 31 ILSASRDKTIIMWKLTRDET------NYGIPQRALRGHS--HFVSDVV---ISSDGQFAL 79 +++ S DKT+ W + + N +P L + D++ +S D ++ Sbjct: 488 LVTGSADKTVKFWDFKVENSLVPGTKNKFLPVLKLHHDTTLELTDDILCVRVSPDDRYLA 547 Query: 80 SGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNT-LGVC 138 D T++++ L + GH VLS+ S D++ I++ S DK IK+W G C Sbjct: 548 ISLLDNTVKVFFLDSMKFYLSLYGHKLPVLSIDISFDSKMIITSSADKNIKIWGLDFGDC 607 Query: 139 KYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTV 198 ++ +H + + V+F P S N SC D +VK W+ + H + + Sbjct: 608 HKSLF--AHQDSIMNVKFLPQSHN--FFSCSKDAVVKYWDGEKFECIQKLYAHQSEVWAL 663 Query: 199 TVSPDGSLCASGGKDGQAMLWDLNEGK 225 V+ DG S D +W+ E + Sbjct: 664 AVATDGGFVVSSSHDHSIRIWEETEDQ 690 Score = 60.1 bits (144), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 61/259 (23%), Positives = 111/259 (42%), Gaps = 33/259 (12%) Query: 75 GQFALSGSWDGTLRLWDLTTGTTTRRFV-GHTKDVLSVAFSSDNRQIVSGSRDKTIKLWN 133 G + G+ +G L+L+DL + + H + S+ +SD +++V+GS DKT+K W+ Sbjct: 442 GLLVILGTRNGELQLFDLASSSLLDTIEDAHDAAIWSLDLTSDGKRLVTGSADKTVKFWD 501 Query: 134 T--------------LGVCKYTVQDESHSEW---VSCVRFSPNSSNPIIVSCGWDKLVKV 176 L V K + ++ E + CVR SP+ + + D VKV Sbjct: 502 FKVENSLVPGTKNKFLPVLK--LHHDTTLELTDDILCVRVSPD--DRYLAISLLDNTVKV 557 Query: 177 WNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGK-HLYTLDGGDI 235 + L + K + GH + ++ +S D + + D +W L+ G H D Sbjct: 558 FFLDSMKFYLSLYGHKLPVLSIDISFDSKMIITSSADKNIKIWGLDFGDCHKSLFAHQDS 617 Query: 236 INALCFSPNRY-WLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSAD 294 I + F P + + + +K WD E + +L A + +LA + D Sbjct: 618 IMNVKFLPQSHNFFSCSKDAVVKYWDGEKFECIQKLY---------AHQSEVWALAVATD 668 Query: 295 GQTLFAGYTDNLVRVWQVT 313 G + + D+ +R+W+ T Sbjct: 669 GGFVVSSSHDHSIRIWEET 687 Score = 59.3 bits (142), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 41/146 (28%), Positives = 70/146 (47%), Gaps = 14/146 (9%) Query: 81 GSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLG-VCK 139 G DG +++WDL + T F GH + + F +++SGS+D I +W+ +G V Sbjct: 97 GYADGVIKVWDLMSKTVLLNFNGHKAAITLLQFDGTGTRLISGSKDSNIIVWDLVGEVGL 156 Query: 140 YTVQDESHSEWVS---CVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLN 196 Y ++ SH + ++ C ++S D ++K+W+L + HI HTG Sbjct: 157 YKLR--SHKDSITGFWC------QGEDWLISTSKDGMIKLWDLKTHQCIETHIAHTGECW 208 Query: 197 TVTVSPDGSLCASGGKDGQAMLWDLN 222 + V D L + G D Q +W L+ Sbjct: 209 GLAVKDD--LLITTGTDSQVKIWKLD 232 Score = 48.1 bits (113), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 33/131 (25%), Positives = 59/131 (45%), Gaps = 6/131 (4%) Query: 3 EQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGH 62 + M +L GH V I + MI+++S DK I +W L ++G ++L H Sbjct: 561 DSMKFYLSLYGHKLPVLSIDISFD-SKMIITSSADKNIKIWGL-----DFGDCHKSLFAH 614 Query: 63 SHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVS 122 + +V S S D ++ WD ++ H +V ++A ++D +VS Sbjct: 615 QDSIMNVKFLPQSHNFFSCSKDAVVKYWDGEKFECIQKLYAHQSEVWALAVATDGGFVVS 674 Query: 123 GSRDKTIKLWN 133 S D +I++W Sbjct: 675 SSHDHSIRIWE 685 Score = 42.7 bits (99), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 38/164 (23%), Positives = 65/164 (39%), Gaps = 12/164 (7%) Query: 152 SCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGG 211 C + ++ D ++KVW+L + + N GH + + G+ SG Sbjct: 81 ECTYLEAHKDTDLLAVGYADGVIKVWDLMSKTVLLNFNGHKAAITLLQFDGTGTRLISGS 140 Query: 212 KDGQAMLWDLNEGKHLYTLDG-GDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDEL 270 KD ++WDL LY L D I + + + IK+WDL+ ++ Sbjct: 141 KDSNIIVWDLVGEVGLYKLRSHKDSITGFWCQGEDWLISTSKDGMIKLWDLKTHQCIE-- 198 Query: 271 KQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTI 314 + A +C LA D L TD+ V++W++ I Sbjct: 199 -------THIAHTGECWGLAVKDD--LLITTGTDSQVKIWKLDI 233 Score = 37.0 bits (84), Expect = 0.011, Method: Compositional matrix adjust. Identities = 27/102 (26%), Positives = 47/102 (46%), Gaps = 8/102 (7%) Query: 31 ILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLW 90 ++S S+D II+W L + Y LR H ++ + + +S S DG ++LW Sbjct: 136 LISGSKDSNIIVWDLVGEVGLY-----KLRSHKDSITGFWCQGE-DWLISTSKDGMIKLW 189 Query: 91 DLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLW 132 DL T + HT + +A D +++ D +K+W Sbjct: 190 DLKTHQCIETHIAHTGECWGLAVKDD--LLITTGTDSQVKIW 229 Score = 35.4 bits (80), Expect = 0.029, Method: Compositional matrix adjust. Identities = 19/68 (27%), Positives = 33/68 (48%), Gaps = 3/68 (4%) Query: 248 LCAATGPSIKIWDLEGKIIVDELKQEV---ISTSSKAEPPQCTSLAWSADGQTLFAGYTD 304 L + + IWD++ +V +L + S + A+P +CT L D L GY D Sbjct: 41 LITSALEDVNIWDIKTGDLVSKLSDGLPPGASDARGAKPAECTYLEAHKDTDLLAVGYAD 100 Query: 305 NLVRVWQV 312 +++VW + Sbjct: 101 GVIKVWDL 108 Score = 33.1 bits (74), Expect = 0.15, Method: Compositional matrix adjust. Identities = 30/122 (24%), Positives = 52/122 (42%), Gaps = 8/122 (6%) Query: 59 LRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNR 118 GH ++ + G +SGS D + +WDL + H KD ++ + Sbjct: 117 FNGHKAAITLLQFDGTGTRLISGSKDSNIIVWDLVGEVGLYKLRSH-KDSITGFWCQGED 175 Query: 119 QIVSGSRDKTIKLWN-TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVW 177 ++S S+D IKLW+ C T + W V+ + ++++ G D VK+W Sbjct: 176 WLISTSKDGMIKLWDLKTHQCIETHIAHTGECWGLAVK------DDLLITTGTDSQVKIW 229 Query: 178 NL 179 L Sbjct: 230 KL 231 Score = 30.4 bits (67), Expect = 0.97, Method: Compositional matrix adjust. Identities = 28/134 (20%), Positives = 53/134 (39%), Gaps = 12/134 (8%) Query: 184 LKTNHI---GHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALC 240 LKT+ I G + ++ +S D L A+ +G +W++ K + T + G + Sbjct: 380 LKTHTIELQGQRTDVRSIDISDDNKLLATAS-NGSLKIWNIKTHKCIRTFECGYALTCKF 438 Query: 241 FSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFA 300 + ++++DL ++D T A SL ++DG+ L Sbjct: 439 LPGGLLVILGTRNGELQLFDLASSSLLD--------TIEDAHDAAIWSLDLTSDGKRLVT 490 Query: 301 GYTDNLVRVWQVTI 314 G D V+ W + Sbjct: 491 GSADKTVKFWDFKV 504 Score = 27.7 bits (60), Expect = 7.2, Method: Compositional matrix adjust. Identities = 23/93 (24%), Positives = 41/93 (44%), Gaps = 7/93 (7%) Query: 174 VKVWNLANCK-LKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG 232 +K+WN+ K ++T GY T P G L G ++G+ L+DL L T++ Sbjct: 414 LKIWNIKTHKCIRT---FECGYALTCKFLPGGLLVILGTRNGELQLFDLASSSLLDTIED 470 Query: 233 GD---IINALCFSPNRYWLCAATGPSIKIWDLE 262 I + S + + + ++K WD + Sbjct: 471 AHDAAIWSLDLTSDGKRLVTGSADKTVKFWDFK 503 >5MWJ-A nrPDB Length = 337 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 51/205 (24%), Positives = 87/205 (42%), Gaps = 11/205 (5%) Query: 53 GIPQRALR----GHSHFVSDVVISSDGQFALSGSWDGTLRLWDLT-----TGTTTRRFVG 103 GIP+ A + H V V IS+ + +G G +++WD++ + + + Sbjct: 37 GIPRHARQINTLNHGEVVCAVTISNPTRHVYTGG-KGCVKVWDISHPGNKSPVSQLDCLN 95 Query: 104 HTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNP 163 + S D ++ G T+ +W+ L ++ E S +C + + + Sbjct: 96 RDNYIRSCKLLPDGCTLIVGGEASTLSIWD-LAAPTPRIKAELTSSAPACYALAISPDSK 154 Query: 164 IIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNE 223 + SC D + VW+L N L GHT + + +S DG+ +GG D WDL E Sbjct: 155 VCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLRE 214 Query: 224 GKHLYTLDGGDIINALCFSPNRYWL 248 G+ L D I +L + P WL Sbjct: 215 GRQLQQHDFTSQIFSLGYCPTGEWL 239 Score = 40.0 bits (92), Expect = 0.001, Method: Compositional matrix adjust. Identities = 47/183 (25%), Positives = 74/183 (40%), Gaps = 25/183 (13%) Query: 146 SHSEWVSCVRFSPNSSNPII-VSCGWDKLVKVWNLANCKLKT-----NHIGHTGYLNTVT 199 +H E V V S NP V G VKVW++++ K+ + + Y+ + Sbjct: 49 NHGEVVCAVTIS----NPTRHVYTGGKGCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCK 104 Query: 200 VSPDGSLCASGGKDGQAMLWDLNEGKHLYTLD---GGDIINALCFSPNRY--WLCAATGP 254 + PDG GG+ +WDL + AL SP+ + C + G Sbjct: 105 LLPDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSDG- 163 Query: 255 SIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTI 314 +I +WDL + +V + + S C + S DG L+ G DN VR W + Sbjct: 164 NIAVWDLHNQTLVRQFQGHTDGAS-------CIDI--SNDGTKLWTGGLDNTVRSWDLRE 214 Query: 315 GTR 317 G + Sbjct: 215 GRQ 217 Score = 28.1 bits (61), Expect = 4.7, Method: Compositional matrix adjust. Identities = 19/66 (28%), Positives = 29/66 (43%), Gaps = 7/66 (10%) Query: 76 QFALSGSW------DGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTI 129 +FA G W D L W G + + + VLS S D++ IV+GS DK Sbjct: 272 KFAYCGKWFVSTGKDNLLNAWRTPYGASIFQ-SKESSSVLSCDISVDDKYIVTGSGDKKA 330 Query: 130 KLWNTL 135 ++ + Sbjct: 331 TVYEVI 336 >3C9C-A nrPDB Length = 432 Score = 61.2 bits (147), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 62/244 (25%), Positives = 109/244 (44%), Gaps = 27/244 (11%) Query: 4 QMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGI--PQRALRG 61 Q LR L+GH ++ P +LSAS D TI +W + + + + G Sbjct: 174 QPDLR--LRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTG 231 Query: 62 HSHFVSDVV--ISSDGQFALSGSWDGTLRLWDLTTGTTTRR---FVGHTKDVLSVAFSSD 116 H+ V DV + + F S + D L +WD T++ HT +V ++F+ Sbjct: 232 HTAVVEDVAWHLLHESLFG-SVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPY 290 Query: 117 NRQIVS-GSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVK 175 + I++ GS DKT+ LW+ + ESH + + V++SP++ I+ S G D+ + Sbjct: 291 SEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNET-ILASSGTDRRLH 349 Query: 176 VWNLANC--------------KLKTNHIGHTGYLNTVTVSPDGS-LCASGGKDGQAMLWD 220 VW+L+ +L H GHT ++ + +P+ + S +D +W Sbjct: 350 VWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQ 409 Query: 221 LNEG 224 + E Sbjct: 410 MAEN 413 >3JB9-L nrPDB Length = 340 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 57/215 (26%), Positives = 91/215 (42%), Gaps = 13/215 (6%) Query: 100 RFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLG-VCKYTVQDESHSEWVSCVRFSP 158 + GHT +VL F SG D+ I LWN G V Y V + ++ +++S Sbjct: 45 QMFGHTAEVLVARFDPSGSYFASGGMDRQILLWNVFGDVKNYGVLNGCKGA-ITDLQWSR 103 Query: 159 NSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGS-LCASGGKDGQAM 217 +S ++ D + W+ + + H GH G +N + V GS L S D Sbjct: 104 DSR--VVYCSSSDTHLMSWDAVSGQKIRKHKGHAGVVNALDVLKVGSELLTSVSDDCTMK 161 Query: 218 LWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVIST 277 +WD + T++ + A+ A G + I ++G I + +L+ S Sbjct: 162 VWDSRSKDCIKTIEEKYPLTAVAI--------AQQGTQVFIGGIDGAIKIWDLRNNHCSH 213 Query: 278 SSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQV 312 K TSLA S DG +L + DN VR++ V Sbjct: 214 VLKGHKDIITSLAISKDGSSLLSNSMDNTVRIFDV 248 Score = 57.4 bits (137), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 54/224 (24%), Positives = 91/224 (40%), Gaps = 28/224 (12%) Query: 12 KGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVI 71 KGH G V + +++ S S D T+ +W + I ++ + ++ V I Sbjct: 132 KGHAGVVNALDVLKVGSELLTSVSDDCTMKVWDSRSKDCIKTIEEK------YPLTAVAI 185 Query: 72 SSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKL 131 + G G DG +++WDL + GH + S+A S D ++S S D T+++ Sbjct: 186 AQQGTQVFIGGIDGAIKIWDLRNNHCSHVLKGHKDIITSLAISKDGSSLLSNSMDNTVRI 245 Query: 132 WNT---------LGVCKYTVQDESHS----EWVSCVRFSPNSSNPIIVSCGWDKLVKVWN 178 ++ L + + + + H+ W RF S+ DK V VW+ Sbjct: 246 FDVKPFASAQRQLQIFEGAIHGQEHNLLGVAWSRNSRFVGAGSS--------DKNVYVWS 297 Query: 179 LANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLN 222 A L+ GH G +N V P + S D L +LN Sbjct: 298 -ATGDLRYVLPGHEGSVNHVDFHPHQDIILSCSSDRTIFLGELN 340 Score = 57.4 bits (137), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 68/285 (23%), Positives = 119/285 (41%), Gaps = 30/285 (10%) Query: 33 SASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDL 92 S D+ I++W + D NYG+ L G ++D+ S D + S D L WD Sbjct: 67 SGGMDRQILLWNVFGDVKNYGV----LNGCKGAITDLQWSRDSRVVYCSSSDTHLMSWDA 122 Query: 93 TTGTTTRRFVGHTK-----DVLSVAFSSDNRQIVSGSRDKTIKLWNTLGV-CKYTVQDES 146 +G R+ GH DVL V + + S S D T+K+W++ C T++++ Sbjct: 123 VSGQKIRKHKGHAGVVNALDVLKVG----SELLTSVSDDCTMKVWDSRSKDCIKTIEEKY 178 Query: 147 HSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSL 206 ++ V + + I G D +K+W+L N GH + ++ +S DGS Sbjct: 179 P---LTAVAIAQQGTQVFI--GGIDGAIKIWDLRNNHCSHVLKGHKDIITSLAISKDGSS 233 Query: 207 CASGGKDGQAMLWDL----NEGKHLYTLDG---GDIINALCFS---PNRYWLCAATGPSI 256 S D ++D+ + + L +G G N L + +R+ ++ ++ Sbjct: 234 LLSNSMDNTVRIFDVKPFASAQRQLQIFEGAIHGQEHNLLGVAWSRNSRFVGAGSSDKNV 293 Query: 257 KIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAG 301 +W G + E P Q L+ S+D +T+F G Sbjct: 294 YVWSATGDLRYVLPGHEGSVNHVDFHPHQDIILSCSSD-RTIFLG 337 >3ODT-A nrPDB Length = 313 Score = 58.9 bits (141), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 58/179 (32%), Positives = 84/179 (46%), Gaps = 21/179 (11%) Query: 10 TLKGHNGWVTQIATTPQFPD-MILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSD 68 TL GH G V ++ F D +++S S DKT +WK G L+ H+ V D Sbjct: 99 TLIGHQGNVCSLS----FQDGVVISGSWDKTAKVWK-------EGSLVYNLQAHNASVWD 147 Query: 69 --VVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRD 126 VV S+ +F L+ S D T++LW + F G DV+ D+ +S S D Sbjct: 148 AKVVSFSENKF-LTASADKTIKLWQ--NDKVIKTFSGIHNDVVRHLAVVDDGHFISCSND 204 Query: 127 KTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLK 185 IKL + + E H +V C++ PN IVSCG D+ V++W+ N LK Sbjct: 205 GLIKLVD-MHTGDVLRTYEGHESFVYCIKLLPNGD---IVSCGEDRTVRIWSKENGSLK 259 Score = 49.3 bits (116), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 52/193 (26%), Positives = 82/193 (42%), Gaps = 17/193 (8%) Query: 55 PQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTK---DVLSV 111 P L GH V +S +SGSWD T ++W G+ H D V Sbjct: 96 PLYTLIGHQGNVCS--LSFQDGVVISGSWDKTAKVW--KEGSLVYNLQAHNASVWDAKVV 151 Query: 112 AFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWD 171 +FS + + ++ S DKTIKLW V K H++ VR + +SC D Sbjct: 152 SFSEN--KFLTASADKTIKLWQNDKVIK--TFSGIHND---VVRHLAVVDDGHFISCSND 204 Query: 172 KLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEG--KHLYT 229 L+K+ ++ + + GH ++ + + P+G + S G+D +W G K + T Sbjct: 205 GLIKLVDMHTGDVLRTYEGHESFVYCIKLLPNGDI-VSCGEDRTVRIWSKENGSLKQVIT 263 Query: 230 LDGGDIINALCFS 242 L I + C S Sbjct: 264 LPAISIWSVDCMS 276 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 77/299 (25%), Positives = 114/299 (38%), Gaps = 67/299 (22%) Query: 59 LRGHSHFVSDVVISSDGQFALSGSWDGTLRLW---DLTTGTTT----------------- 98 L+GH V DVV D + A S S DGT+RLW D GT Sbjct: 14 LKGHDQDVRDVVAVDDSKVA-SVSRDGTVRLWSKDDQWLGTVVYTGQGFLNSVCYDSEKE 72 Query: 99 -------------------------RRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWN 133 +GH +V S++F + ++SGS DKT K+W Sbjct: 73 LLLFGGKDTMINGVPLFATSGEDPLYTLIGHQGNVCSLSFQ--DGVVISGSWDKTAKVWK 130 Query: 134 TLGVCKYTVQDESHSEW-VSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHT 192 G Y +Q + S W V FS N ++ DK +K+W + +KT H Sbjct: 131 E-GSLVYNLQAHNASVWDAKVVSFSENK----FLTASADKTIKLWQ-NDKVIKTFSGIHN 184 Query: 193 GYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGD-IINALCFSPNRYWLCAA 251 + + V DG S DG L D++ G L T +G + + + PN + Sbjct: 185 DVVRHLAVVDDGHFI-SCSNDGLIKLVDMHTGDVLRTYEGHESFVYCIKLLPNGDIVSCG 243 Query: 252 TGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVW 310 +++IW E LKQ + + C S + G +DNLVR++ Sbjct: 244 EDRTVRIWSKENG----SLKQVITLPAISIWSVDCMS------NGDIIVGSSDNLVRIF 292 >5Y1U-A nrPDB Length = 456 Score = 58.9 bits (141), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 66/269 (24%), Positives = 114/269 (42%), Gaps = 39/269 (14%) Query: 11 LKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTR--DETNYGIPQRALRGHSHFVSD 68 L+GH ++ P +LSAS D TI +W ++ E + GH+ V D Sbjct: 204 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVED 263 Query: 69 VV--ISSDGQFALSGSWDGTLRLWDLTTGTTTR---RFVGHTKDVLSVAFSSDNRQIVS- 122 V + + F S + D L +WD + T++ HT +V ++F+ + I++ Sbjct: 264 VSWHLLHESLFG-SVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILAT 322 Query: 123 GSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANC 182 GS DKT+ LW+ + ESH + + V++SP++ I+ S G D+ + VW+L+ Sbjct: 323 GSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNET-ILASSGTDRRLNVWDLSK- 380 Query: 183 KLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFS 242 IG P L GG + I+ ++ Sbjct: 381 ------IGEEQSPEDAEDGPPELLFIHGGHTAK--------------------ISDFSWN 414 Query: 243 PNRYW-LCAATGPSI-KIWDLEGKIIVDE 269 PN W +C+ + +I ++W + I DE Sbjct: 415 PNEPWVICSVSEDNIMQVWQMAENIYNDE 443 Score = 27.7 bits (60), Expect = 7.6, Method: Compositional matrix adjust. Identities = 29/139 (20%), Positives = 56/139 (40%), Gaps = 20/139 (14%) Query: 10 TLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDV 69 ++ H V ++ P ++ + S DKT+ +W L N + + H + V Sbjct: 299 SVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDL----RNLKLKLHSFESHKDEIFQV 354 Query: 70 VISSDGQFALSGSW-DGTLRLWDLTT------------GTTTRRFV--GHTKDVLSVAFS 114 S + L+ S D L +WDL+ G F+ GHT + +++ Sbjct: 355 QWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWN 414 Query: 115 SDNRQIV-SGSRDKTIKLW 132 + ++ S S D +++W Sbjct: 415 PNEPWVICSVSEDNIMQVW 433 >4N14-A nrPDB Length = 314 Score = 58.9 bits (141), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 66/292 (22%), Positives = 122/292 (41%), Gaps = 28/292 (9%) Query: 31 ILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLW 90 +L+ + D ++ +W + + + + ++S V +G + G+ ++LW Sbjct: 34 VLAVALDNSVYLWSASSGDI---LQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLW 90 Query: 91 DLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEW 150 D+ R H+ V S++++S + SGSR I + + HS+ Sbjct: 91 DVQQQKRLRNMTSHSARVGSLSWNS--YILSSGSRSGHIHHHDVRVAEHHVATLSGHSQE 148 Query: 151 VSCVRFSPNSSNPIIVSCGWDKLVKVWNLAN-----CKLKTNHIGHTGYLNTVTVSP-DG 204 V +R++P+ + + S G D LV VW A L+T H G + V P Sbjct: 149 VCGLRWAPDGRH--LASGGNDNLVNVWPSAPGEGGWVPLQT-FTQHQGAVKAVAWCPWQS 205 Query: 205 SLCASGG--KDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATGPS---IKIW 259 ++ A+GG D +W++ G L +D + ++ +SP+ L + G + + IW Sbjct: 206 NVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIW 265 Query: 260 DLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQ 311 V ELK + SL S DG T+ + D +R+W+ Sbjct: 266 KYPTMAKVAELK---------GHTSRVLSLTMSPDGATVASAAADETLRLWR 308 Score = 38.1 bits (87), Expect = 0.005, Method: Compositional matrix adjust. Identities = 33/130 (25%), Positives = 54/130 (41%), Gaps = 10/130 (7%) Query: 10 TLKGHNGWVTQIATTPQFPDMILSA--SRDKTIIMWKLTRDETNYGIPQRALRGHSHFVS 67 T H G V +A P +++ + + D+ I +W + G A+ HS S Sbjct: 187 TFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCS-----GACLSAVDAHSQVCS 241 Query: 68 DVVISSDGQFALSGS--WDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSR 125 ++ S + +SG L +W T GHT VLS+ S D + S + Sbjct: 242 -ILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAA 300 Query: 126 DKTIKLWNTL 135 D+T++LW Sbjct: 301 DETLRLWRCF 310 >4GGA-A nrPDB Length = 420 Score = 58.5 bits (140), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 66/292 (22%), Positives = 122/292 (41%), Gaps = 28/292 (9%) Query: 31 ILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLW 90 +L+ + D ++ +W + + + + ++S V +G + G+ ++LW Sbjct: 118 VLAVALDNSVYLWSASSGDI---LQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLW 174 Query: 91 DLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEW 150 D+ R H+ V S++++S + SGSR I + + HS+ Sbjct: 175 DVQQQKRLRNMTSHSARVGSLSWNS--YILSSGSRSGHIHHHDVRVAEHHVATLSGHSQE 232 Query: 151 VSCVRFSPNSSNPIIVSCGWDKLVKVWNLAN-----CKLKTNHIGHTGYLNTVTVSP-DG 204 V +R++P+ + + S G D LV VW A L+T H G + V P Sbjct: 233 VCGLRWAPDGRH--LASGGNDNLVNVWPSAPGEGGWVPLQT-FTQHQGAVKAVAWCPWQS 289 Query: 205 SLCASGG--KDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATGPS---IKIW 259 ++ A+GG D +W++ G L +D + ++ +SP+ L + G + + IW Sbjct: 290 NVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIW 349 Query: 260 DLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQ 311 V ELK + SL S DG T+ + D +R+W+ Sbjct: 350 KYPTMAKVAELK---------GHTSRVLSLTMSPDGATVASAAADETLRLWR 392 Score = 37.4 bits (85), Expect = 0.009, Method: Compositional matrix adjust. Identities = 33/127 (25%), Positives = 54/127 (42%), Gaps = 10/127 (7%) Query: 10 TLKGHNGWVTQIATTPQFPDMILSA--SRDKTIIMWKLTRDETNYGIPQRALRGHSHFVS 67 T H G V +A P +++ + + D+ I +W + G A+ HS S Sbjct: 271 TFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCS-----GACLSAVDAHSQVCS 325 Query: 68 DVVISSDGQFALSGS--WDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSR 125 ++ S + +SG L +W T GHT VLS+ S D + S + Sbjct: 326 -ILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAA 384 Query: 126 DKTIKLW 132 D+T++LW Sbjct: 385 DETLRLW 391 >5LCW-Q nrPDB Length = 374 Score = 58.5 bits (140), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 66/292 (22%), Positives = 122/292 (41%), Gaps = 28/292 (9%) Query: 31 ILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLW 90 +L+ + D ++ +W + + + + ++S V +G + G+ ++LW Sbjct: 72 VLAVALDNSVYLWSASSGDI---LQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLW 128 Query: 91 DLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEW 150 D+ R H+ V S++++S + SGSR I + + HS+ Sbjct: 129 DVQQQKRLRNMTSHSARVGSLSWNS--YILSSGSRSGHIHHHDVRVAEHHVATLSGHSQE 186 Query: 151 VSCVRFSPNSSNPIIVSCGWDKLVKVWNLAN-----CKLKTNHIGHTGYLNTVTVSP-DG 204 V +R++P+ + + S G D LV VW A L+T H G + V P Sbjct: 187 VCGLRWAPDGRH--LASGGNDNLVNVWPSAPGEGGWVPLQT-FTQHQGAVKAVAWCPWQS 243 Query: 205 SLCASGG--KDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATGPS---IKIW 259 ++ A+GG D +W++ G L +D + ++ +SP+ L + G + + IW Sbjct: 244 NVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIW 303 Query: 260 DLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQ 311 V ELK + SL S DG T+ + D +R+W+ Sbjct: 304 KYPTMAKVAELK---------GHTSRVLSLTMSPDGATVASAAADETLRLWR 346 Score = 37.4 bits (85), Expect = 0.009, Method: Compositional matrix adjust. Identities = 33/127 (25%), Positives = 54/127 (42%), Gaps = 10/127 (7%) Query: 10 TLKGHNGWVTQIATTPQFPDMILSA--SRDKTIIMWKLTRDETNYGIPQRALRGHSHFVS 67 T H G V +A P +++ + + D+ I +W + G A+ HS S Sbjct: 225 TFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCS-----GACLSAVDAHSQVCS 279 Query: 68 DVVISSDGQFALSGS--WDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSR 125 ++ S + +SG L +W T GHT VLS+ S D + S + Sbjct: 280 -ILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAA 338 Query: 126 DKTIKLW 132 D+T++LW Sbjct: 339 DETLRLW 345 >5L9T-R nrPDB Length = 493 Score = 58.2 bits (139), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 67/262 (25%), Positives = 110/262 (41%), Gaps = 26/262 (9%) Query: 66 VSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSR 125 V+ V S G G+ G +++WD G GHT V ++A++++ Q+ SGSR Sbjct: 232 VTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAE--QLSSGSR 289 Query: 126 DKTIKLWNTLGVCKYTVQDES----HSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLAN 181 D+ I + + +Q E H + V +++S + + ++ S G D + VWN ++ Sbjct: 290 DRMILQRD---IRTPPLQSERRLQGHRQEVCGLKWS--TDHQLLASGGNDNKLLVWNHSS 344 Query: 182 CKLKTNHIGHTGYLNTVTVSP-DGSLCASGG--KDGQAMLWDLNEGKHLYTLDGGDIINA 238 + H + + SP L ASGG D W+ G+ L +D G + Sbjct: 345 LSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCN 404 Query: 239 LCFSPNRYWLCAATGPS---IKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADG 295 L +S + L + G S I +W V +L + LA S DG Sbjct: 405 LAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKL---------TGHSYRVLYLAMSPDG 455 Query: 296 QTLFAGYTDNLVRVWQVTIGTR 317 + + G D +R W V TR Sbjct: 456 EAIVTGAGDETLRFWNVFSKTR 477 Score = 55.8 bits (133), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 53/216 (24%), Positives = 94/216 (43%), Gaps = 15/216 (6%) Query: 11 LKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRD-ETNYGIPQRALRGHSHFVSDV 69 L+GH V +A + + S SRD+ I L RD T +R L+GH V + Sbjct: 267 LEGHTARVGALAWNA---EQLSSGSRDRMI----LQRDIRTPPLQSERRLQGHRQEVCGL 319 Query: 70 VISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVS---GSRD 126 S+D Q SG D L +W+ ++ + +++ H V ++A+S +++ G+ D Sbjct: 320 KWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTAD 379 Query: 127 KTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDK-LVKVWNLANCKLK 185 + I+ WNTL D C +N ++ + G+ + + VW + Sbjct: 380 RCIRFWNTLTGQPLQCIDTGSQ---VCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQV 436 Query: 186 TNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDL 221 GH+ + + +SPDG +G D W++ Sbjct: 437 AKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNV 472 Score = 39.3 bits (90), Expect = 0.003, Method: Compositional matrix adjust. Identities = 18/58 (31%), Positives = 30/58 (51%) Query: 89 LWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDES 146 +W + T + GH+ VL +A S D IV+G+ D+T++ WN + T + S Sbjct: 427 VWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKTRSTKESVS 484 Score = 33.5 bits (75), Expect = 0.13, Method: Compositional matrix adjust. Identities = 19/53 (35%), Positives = 32/53 (60%), Gaps = 6/53 (11%) Query: 59 LRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSV 111 L GHS+ V + +S DG+ ++G+ D TLR W++ + T + TK+ +SV Sbjct: 439 LTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKTRS------TKESVSV 485 >5G04-R nrPDB Length = 499 Score = 58.2 bits (139), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 66/292 (22%), Positives = 121/292 (41%), Gaps = 28/292 (9%) Query: 31 ILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLW 90 +L+ + D ++ +W + + + + ++S V +G + G+ ++LW Sbjct: 197 VLAVALDNSVYLWSASSGDI---LQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLW 253 Query: 91 DLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEW 150 D+ R H+ V S++++S + SGSR I + + HS+ Sbjct: 254 DVQQQKRLRNMTSHSARVGSLSWNS--YILSSGSRSGHIHHHDVRVAEHHVATLSGHSQE 311 Query: 151 VSCVRFSPNSSNPIIVSCGWDKLVKVWNLAN-----CKLKTNHIGHTGYLNTVTVSP-DG 204 V +R++P+ + + S G D LV VW A L+T H G + V P Sbjct: 312 VCGLRWAPDGRH--LASGGNDNLVNVWPSAPGEGGWVPLQT-FTQHQGAVKAVAWCPWQS 368 Query: 205 SLCASGG--KDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATG---PSIKIW 259 ++ A+GG D +W++ G L +D + ++ +SP+ L + G + IW Sbjct: 369 NVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIW 428 Query: 260 DLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQ 311 V ELK + SL S DG T+ + D +R+W+ Sbjct: 429 KYPTMAKVAELKGHTS---------RVLSLTMSPDGATVASAAADETLRLWR 471 Score = 36.2 bits (82), Expect = 0.018, Method: Compositional matrix adjust. Identities = 33/127 (25%), Positives = 54/127 (42%), Gaps = 10/127 (7%) Query: 10 TLKGHNGWVTQIATTPQFPDMILSA--SRDKTIIMWKLTRDETNYGIPQRALRGHSHFVS 67 T H G V +A P +++ + + D+ I +W + G A+ HS S Sbjct: 350 TFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCS-----GACLSAVDAHSQVCS 404 Query: 68 DVVISSDGQFALSGS--WDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSR 125 ++ S + +SG L +W T GHT VLS+ S D + S + Sbjct: 405 -ILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAA 463 Query: 126 DKTIKLW 132 D+T++LW Sbjct: 464 DETLRLW 470 >6BX3-A nrPDB Length = 314 Score = 58.2 bits (139), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 69/271 (25%), Positives = 118/271 (43%), Gaps = 47/271 (17%) Query: 5 MTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSH 64 +T GT G +I+ QF L+ ++ I+++ + R + Q + H+ Sbjct: 4 VTPVGTQNGLKATCAKISPDGQF----LAITQGLNILIYDINRRT----VSQTLVTSHAR 55 Query: 65 FVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGS 124 S++ S DGQ + S D ++ + L+ G F+GHT V+S+ F+ + + S Sbjct: 56 PFSELCWSPDGQCIATASDDFSVEIIHLSYGLL-HTFIGHTAPVISLTFNRKGNLLFTSS 114 Query: 125 RDKTIKLWNTL-GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCK 183 D++IK+W+TL G T+ +HSE V V N S+ I+ S +D L+++++ Sbjct: 115 MDESIKIWDTLNGSLMKTI--SAHSEAVVSVDVPMNDSS-ILSSGSYDGLIRIFDAET-- 169 Query: 184 LKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSP 243 GH L T+T D W +G I+ + FS Sbjct: 170 ------GHC--LKTLTYDKD---------------WKRE--------NGVVPISQVKFSE 198 Query: 244 N-RYWLCAATGPSIKIWDLEGKIIVDELKQE 273 N RY L + +KIWD G +V + + Sbjct: 199 NARYLLVKSLDGVVKIWDCIGGCVVRTFQVQ 229 Score = 28.9 bits (63), Expect = 2.7, Method: Compositional matrix adjust. Identities = 20/75 (26%), Positives = 33/75 (44%), Gaps = 8/75 (10%) Query: 241 FSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFA 300 SP+ +L G +I I+D+ + + L +S A P + L WS DGQ + Sbjct: 20 ISPDGQFLAITQGLNILIYDINRRTVSQTL------VTSHARP--FSELCWSPDGQCIAT 71 Query: 301 GYTDNLVRVWQVTIG 315 D V + ++ G Sbjct: 72 ASDDFSVEIIHLSYG 86 >5WBU-D nrPDB Length = 328 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 71/321 (22%), Positives = 124/321 (38%), Gaps = 63/321 (19%) Query: 28 PDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTL 87 P ++ +A D T+ W + + GI R ++ V+ + ++ D + + + Sbjct: 14 PVILATAGYDHTVRFW-----QAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQ-HI 67 Query: 88 RLWDLTTGTTTR--RFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLG---VCKYTV 142 R++DL + + G K++ SV F D R + +G D T ++W+ C+ Sbjct: 68 RMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIF 127 Query: 143 QDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGH-----TGYLNT 197 Q + ++CV PN + I+ + +W+ LKT+H + + Sbjct: 128 QVNAP---INCVCLHPNQAELIVGD--QSGAIHIWD-----LKTDHNEQLIPEPEVSITS 177 Query: 198 VTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALC----------------F 241 + PD S A+ G +W+L G GD + L F Sbjct: 178 AHIDPDASYMAAVNSTGNCYVWNLTGGI-------GDEVTQLIPKTKIPAHTRYALQCRF 230 Query: 242 SPNRYWLCAATG-PSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAW------SAD 294 SP+ L + + KIW ++ EL S K+ P +S W S D Sbjct: 231 SPDSTLLATCSADQTCKIWRTSNFSLMTEL-------SIKSGNPGESSRGWMWGCAFSGD 283 Query: 295 GQTLFAGYTDNLVRVWQVTIG 315 Q + +DNL R+W V G Sbjct: 284 SQYIVTASSDNLARLWCVETG 304 Score = 45.1 bits (105), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 30/117 (25%), Positives = 53/117 (45%), Gaps = 10/117 (8%) Query: 4 QMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWK------LTRDETNYGIPQR 57 Q+ + + H + Q +P ++ + S D+T +W+ +T G P Sbjct: 211 QLIPKTKIPAHTRYALQCRFSPD-STLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGE 269 Query: 58 ALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFS 114 + RG ++ S D Q+ ++ S D RLW + TG R + GH K V+ +AF+ Sbjct: 270 SSRG---WMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFN 323 Score = 45.1 bits (105), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 43/192 (22%), Positives = 75/192 (39%), Gaps = 23/192 (11%) Query: 15 NGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSD 74 N + + P ++I+ + I +W L D IP+ + ++ I D Sbjct: 130 NAPINCVCLHPNQAELIV-GDQSGAIHIWDLKTDHNEQLIPEPEVS-----ITSAHIDPD 183 Query: 75 GQFALSGSWDGTLRLWDLTTGTTTR--------RFVGHTKDVLSVAFSSDNRQIVSGSRD 126 + + + G +W+LT G + HT+ L FS D+ + + S D Sbjct: 184 ASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSAD 243 Query: 127 KTIKLWNTLGVCKYTV-------QDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNL 179 +T K+W T T ES W+ FS +S IV+ D L ++W + Sbjct: 244 QTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQ--YIVTASSDNLARLWCV 301 Query: 180 ANCKLKTNHIGH 191 ++K + GH Sbjct: 302 ETGEIKREYGGH 313 >4AEZ-A nrPDB Length = 401 Score = 55.5 bits (132), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 62/260 (23%), Positives = 108/260 (41%), Gaps = 19/260 (7%) Query: 63 SHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIV- 121 S +V+ V S DG F G +G + ++D+ + T R GH V +++ NR ++ Sbjct: 134 STYVASVKWSHDGSFLSVGLGNGLVDIYDVESQTKLRTMAGHQARVGCLSW---NRHVLS 190 Query: 122 SGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLAN 181 SGSR I + + HS V + + S + S G D +V++W+ + Sbjct: 191 SGSRSGAIHHHDVRIANHQIGTLQGHSSEVCGLAW--RSDGLQLASGGNDNVVQIWDARS 248 Query: 182 CKLKTNHIGHTGYLNTVTVSP-DGSLCASGG--KDGQAMLWDLNEGKHLYTLDGGDIINA 238 K H + V P +L A+GG D Q W+ G + T+D G + + Sbjct: 249 SIPKFTKTNHNAAVKAVAWCPWQSNLLATGGGTMDKQIHFWNAATGARVNTVDAGSQVTS 308 Query: 239 LCFSPNRYWLCAATG---PSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADG 295 L +SP+ + + G ++ IW + ++ T + A S DG Sbjct: 309 LIWSPHSKEIMSTHGFPDNNLSIWSYSSSGLTKQVDIPAHDT-------RVLYSALSPDG 361 Query: 296 QTLFAGYTDNLVRVWQVTIG 315 + L +D ++ W+V G Sbjct: 362 RILSTAASDENLKFWRVYDG 381 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 40/174 (22%), Positives = 73/174 (41%), Gaps = 7/174 (4%) Query: 59 LRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNR 118 L+GHS V + SDG SG D +++WD + H V +VA+ Sbjct: 213 LQGHSSEVCGLAWRSDGLQLASGGNDNVVQIWDARSSIPKFTKTNHNAAVKAVAWCPWQS 272 Query: 119 QIVS---GSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVK 175 +++ G+ DK I WN + D V+ + +SP+S + D + Sbjct: 273 NLLATGGGTMDKQIHFWNAATGARVNTVDAGSQ--VTSLIWSPHSKEIMSTHGFPDNNLS 330 Query: 176 VWNLANCKL--KTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHL 227 +W+ ++ L + + H + +SPDG + ++ D W + +G H+ Sbjct: 331 IWSYSSSGLTKQVDIPAHDTRVLYSALSPDGRILSTAASDENLKFWRVYDGDHV 384 Score = 40.0 bits (92), Expect = 0.001, Method: Compositional matrix adjust. Identities = 38/151 (25%), Positives = 68/151 (45%), Gaps = 9/151 (5%) Query: 161 SNPIIVSCGWDKLVKVWNLANCKLKT-NHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLW 219 SN +V+ ++ V VWN + + + Y+ +V S DGS + G +G ++ Sbjct: 102 SNLNVVAVALERNVYVWNADSGSVSALAETDESTYVASVKWSHDGSFLSVGLGNGLVDIY 161 Query: 220 DLNEGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSS 279 D+ L T+ G C S NR+ L + + S I + +I ++ + Sbjct: 162 DVESQTKLRTM-AGHQARVGCLSWNRHVLSSGSR-SGAIHHHDVRIANHQIG------TL 213 Query: 280 KAEPPQCTSLAWSADGQTLFAGYTDNLVRVW 310 + + LAW +DG L +G DN+V++W Sbjct: 214 QGHSSEVCGLAWRSDGLQLASGGNDNVVQIW 244 >4L9O-A nrPDB Length = 349 Score = 55.1 bits (131), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 65/245 (26%), Positives = 105/245 (42%), Gaps = 27/245 (11%) Query: 3 EQMTLRGTLKGHNGWVTQIA-TTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRG 61 E L TL GH G V Q+A P+F ++ S S D +++WK E N G+ + Sbjct: 101 ENQRLVETLIGHEGPVWQVAWAHPKFGVILASCSYDGKVLIWK----EDN-GVWNKVAEH 155 Query: 62 HSHFVSDVVIS----SDGQFALSGSWDGTLRLWDLTTGTTTRRFV--GHTKDV-----LS 110 H S +S G L S DG + + + G V GH V Sbjct: 156 SVHQASVNSVSWAPHEYGPVLLCASSDGKISIVEFKDGGALEPIVIQGHAIGVNAASWAP 215 Query: 111 VAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDES---HSEWVSCVRFSPNS-SNPIIV 166 ++ + R+ VSG D +K+W K +++E+ HS+WV V +SP+ S I Sbjct: 216 ISLPDNTRRFVSGGCDNLVKIWRYDDAAKTFIEEEAFQGHSDWVRDVAWSPSRLSKSYIA 275 Query: 167 SCGWDKLVKVW--NLANCKLKTNHIGHTGYLNT---VTVSPDGSLCASGGKDGQAMLWDL 221 + D+ V +W + + K + + + + + S G++ A G D + LW Sbjct: 276 TASQDRTVLIWTKDGKSNKWEKQPLTKEKFPDVCWRASWSLSGNVLAISGGDNKVTLWKE 335 Query: 222 N-EGK 225 N +GK Sbjct: 336 NIQGK 340 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 58/276 (21%), Positives = 109/276 (39%), Gaps = 27/276 (9%) Query: 61 GHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTR---RFVGHTKDVLSVAFSSDN 117 H + D V+ G+ + S D T++++++ G R +GH V VA++ Sbjct: 67 AHDDLIHDAVLDYYGRRLATCSSDKTIKIFEID-GENQRLVETLIGHEGPVWQVAWAHPK 125 Query: 118 RQIV--SGSRDKTIKLWNT-LGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLV 174 ++ S S D + +W GV + H V+ V ++P+ P+++ D + Sbjct: 126 FGVILASCSYDGKVLIWKEDNGVWNKVAEHSVHQASVNSVSWAPHEYGPVLLCASSDGKI 185 Query: 175 KVWNLANCKLKTNHI--GHTGYLNTVTVSP-----DGSLCASGGKDGQAMLWDLNEGKHL 227 + + + GH +N + +P + SGG D +W ++ Sbjct: 186 SIVEFKDGGALEPIVIQGHAIGVNAASWAPISLPDNTRRFVSGGCDNLVKIWRYDDAAKT 245 Query: 228 YTLDGG-----DIINALCFSPNR----YWLCAATGPSIKIWDLEGKIIVDELKQEVISTS 278 + + D + + +SP+R Y A+ ++ IW +GK K E + Sbjct: 246 FIEEEAFQGHSDWVRDVAWSPSRLSKSYIATASQDRTVLIWTKDGK----SNKWEKQPLT 301 Query: 279 SKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTI 314 + P C +WS G L DN V +W+ I Sbjct: 302 KEKFPDVCWRASWSLSGNVLAISGGDNKVTLWKENI 337 >6J6H-n nrPDB Length = 455 Score = 54.7 bits (130), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 60/267 (22%), Positives = 114/267 (42%), Gaps = 16/267 (5%) Query: 54 IPQRALR---GHSHFVSDV-VISSDGQFALSGSWDGTLRLWDLTTGTT-TRRFVGHTKDV 108 +P++ +R GH + + + G LSG D T+++WD R F GH K + Sbjct: 150 LPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPI 209 Query: 109 LSVAFSSDNRQIVSGSRDKTIKLWNT-LGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVS 167 ++ F+ D + +S S D+++K+W+T G K + S + V P + + IV Sbjct: 210 KALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNS---TPADVESRPTNPHEFIVG 266 Query: 168 CGWDKLVKVWNL--ANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWD--LNE 223 K++ + N L + H + + PDGS S +D +W+ +N Sbjct: 267 LSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINV 326 Query: 224 GKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEP 283 + + L P++ + CA + + +I+ K +++ S A Sbjct: 327 PIKQISDTAQHSMPFLNVHPSQNYFCAQSMDN-RIYSFSLKPKYKRHPKKIFKGHSSAG- 384 Query: 284 PQCTSLAWSADGQTLFAGYTDNLVRVW 310 SLA+S DG+ + +G + + + W Sbjct: 385 -YGISLAFSGDGRYICSGDSKSRLFTW 410 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 45/176 (25%), Positives = 78/176 (44%), Gaps = 9/176 (5%) Query: 13 GHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVIS 72 GH T + P+ +ILS D TI +W D R +GH+ + + + Sbjct: 160 GHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECL----RDFQGHNKPIKALRFT 215 Query: 73 SDGQFALSGSWDGTLRLWDLTTG-TTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKL 131 D Q LS S+D ++++WD TG TR + T + ++ + IV S K + Sbjct: 216 EDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHY 275 Query: 132 WNTLGVCKYTVQD-ESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVW-NLANCKLK 185 + + + VQ + H + +++ P+ S +S DK V++W N N +K Sbjct: 276 DDRVSENQGLVQTYDHHLSSILALKYFPDGSK--FISSSEDKTVRIWENQINVPIK 329 Score = 33.1 bits (74), Expect = 0.16, Method: Compositional matrix adjust. Identities = 31/136 (22%), Positives = 60/136 (44%), Gaps = 17/136 (12%) Query: 8 RGTLKGHNGWVTQIATTPQFPD--MILSASRDKTIIMWKLTRDETNYGIPQRALRGHS-H 64 +G ++ ++ ++ I FPD +S+S DKT+ +W E +P + + + H Sbjct: 283 QGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIW-----ENQINVPIKQISDTAQH 337 Query: 65 FVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRR-----FVGHTKDV--LSVAFSSDN 117 + + + + + S D R++ + +R F GH+ +S+AFS D Sbjct: 338 SMPFLNVHPSQNYFCAQSMDN--RIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDG 395 Query: 118 RQIVSGSRDKTIKLWN 133 R I SG + W+ Sbjct: 396 RYICSGDSKSRLFTWD 411 >5WJC-A nrPDB Length = 430 Score = 54.3 bits (129), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 47/182 (25%), Positives = 80/182 (43%), Gaps = 11/182 (6%) Query: 8 RGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMW-----KLTRDETNYGIPQRALRGH 62 + LKGH + P P + + + D+ I +W T ET P H Sbjct: 175 QAVLKGHTAEGFGLCWNPNLPGNLATGAEDQVICLWDVQTQSFTSSETKVISPIAKYHRH 234 Query: 63 SHFVSDVVISSDGQFALSG-SWDGTLRLWD--LTTGTTTRRFV-GHTKDVLSVAFSSDNR 118 + V+DV + L+ S D TL++ D L + + H+K + +VA + N Sbjct: 235 TDIVNDVQFHPQHEALLASVSDDCTLQIHDTRLNPEEEAPKVIQAHSKAINAVAINPFND 294 Query: 119 QIVS-GSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVW 177 +++ S DKT+ LW+ + E H + V + +SP+ PI+ S D+ V +W Sbjct: 295 YLLATASADKTVALWDLRNPYQRLHTLEGHEDEVYGLEWSPHDE-PILASSSTDRRVCIW 353 Query: 178 NL 179 +L Sbjct: 354 DL 355 Score = 30.4 bits (67), Expect = 1.0, Method: Compositional matrix adjust. Identities = 35/140 (25%), Positives = 59/140 (42%), Gaps = 22/140 (15%) Query: 11 LKGHNGWVTQIATTPQFPDMILS-ASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDV 69 ++ H+ + +A P F D +L+ AS DKT+ +W L L GH V + Sbjct: 277 IQAHSKAINAVAINP-FNDYLLATASADKTVALWDLRNPYQRL----HTLEGHEDEVYGL 331 Query: 70 VISS-DGQFALSGSWDGTLRLWDLTT------------GTTTRRFV--GHTKDVLSVAFS 114 S D S S D + +WDL G+ F+ GHT + ++ Sbjct: 332 EWSPHDEPILASSSTDRRVCIWDLEKIGEEQTPEDAEDGSPELLFMHGGHTNRISEFSWC 391 Query: 115 SDNRQIV-SGSRDKTIKLWN 133 + R +V S + D +++W+ Sbjct: 392 PNERWVVGSLADDNILQIWS 411 >3FM0-A nrPDB Length = 345 Score = 53.5 bits (127), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 35/125 (28%), Positives = 62/125 (49%), Gaps = 5/125 (4%) Query: 10 TLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDV 69 TL+GH V +A P +++ + SRDK++ +W++ DE + L H+ V V Sbjct: 100 TLEGHENEVKSVAWAPS-GNLLATCSRDKSVWVWEV--DEEDEYECVSVLNSHTQDVKHV 156 Query: 70 VISSDGQFALSGSWDGTLRLW--DLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDK 127 V + S S+D T++L+ + GH V S+AF +++ S S D+ Sbjct: 157 VWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDR 216 Query: 128 TIKLW 132 T+++W Sbjct: 217 TVRIW 221 Score = 44.7 bits (104), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 47/201 (23%), Positives = 87/201 (43%), Gaps = 18/201 (8%) Query: 120 IVSGSRDKTIKLWNTLG---VCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKV 176 + S D+ I++W T G +CK +V E H V V +SP + + S +D + Sbjct: 31 LASCGGDRRIRIWGTEGDSWICK-SVLSEGHQRTVRKVAWSPCGN--YLASASFDATTCI 87 Query: 177 W--NLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTL---- 230 W N + + T GH + +V +P G+L A+ +D +W+++E + Sbjct: 88 WKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLN 147 Query: 231 DGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLA 290 + + + P++ L +A+ +D K+ +E V + + SLA Sbjct: 148 SHTQDVKHVVWHPSQELLASAS------YDDTVKLYREEEDDWVCCATLEGHESTVWSLA 201 Query: 291 WSADGQTLFAGYTDNLVRVWQ 311 + GQ L + D VR+W+ Sbjct: 202 FDPSGQRLASCSDDRTVRIWR 222 Score = 43.9 bits (102), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 52/202 (25%), Positives = 82/202 (40%), Gaps = 22/202 (10%) Query: 30 MILSASRDKTIIMWKLTRDETNYGIPQRAL-RGHSHFVSDVVISSDGQFALSGSWDGTLR 88 ++ S D+ I +W E + I + L GH V V S G + S S+D T Sbjct: 30 LLASCGGDRRIRIWGT---EGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASFDATTC 86 Query: 89 LW-----DLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQ 143 +W D TT GH +V SVA++ + + SRDK++ +W +Y Sbjct: 87 IWKKNQDDFECVTT---LEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECV 143 Query: 144 D--ESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLAN----CKLKTNHIGHTGYLNT 197 SH++ V V + P S ++ S +D VK++ C GH + + Sbjct: 144 SVLNSHTQDVKHVVWHP--SQELLASASYDDTVKLYREEEDDWVCCATLE--GHESTVWS 199 Query: 198 VTVSPDGSLCASGGKDGQAMLW 219 + P G AS D +W Sbjct: 200 LAFDPSGQRLASCSDDRTVRIW 221 >5OQL-L nrPDB Length = 557 Score = 53.1 bits (126), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 40/145 (27%), Positives = 71/145 (48%), Gaps = 7/145 (4%) Query: 79 LSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAF---SSDNRQIVSGSRDKTIKLWNTL 135 +S S D T+RLWDL + TR F GHT V AF S+++ +VSGS D+T+++W+ Sbjct: 161 MSCSDDKTVRLWDLPSNDPTRLFTGHTDYVRCGAFMPGSANSNLLVSGSYDETVRVWDAR 220 Query: 136 GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYL 195 V H++ + V P+ + + S ++ + +L TN H + Sbjct: 221 APGG-AVMTFKHADPIEDVLPLPSGTTLLAASGNAISVLDLVAAKPLRLITN---HQKTV 276 Query: 196 NTVTVSPDGSLCASGGKDGQAMLWD 220 +++++ G SG DG +++ Sbjct: 277 TSLSLASQGRRVVSGSLDGHVKVFE 301 Score = 52.0 bits (123), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 46/171 (26%), Positives = 76/171 (44%), Gaps = 14/171 (8%) Query: 147 HSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSP---D 203 H + V ++SP ++SC DK V++W+L + GHT Y+ P + Sbjct: 143 HKQPVWVTKWSPTELT-TLMSCSDDKTVRLWDLPSNDPTRLFTGHTDYVRCGAFMPGSAN 201 Query: 204 GSLCASGGKDGQAMLWDLN-EGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLE 262 +L SG D +WD G + T D I + P+ L AA+G +I + DL Sbjct: 202 SNLLVSGSYDETVRVWDARAPGGAVMTFKHADPIEDVLPLPSGTTLLAASGNAISVLDL- 260 Query: 263 GKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVT 313 V +I+ K TSL+ ++ G+ + +G D V+V++ T Sbjct: 261 ----VAAKPLRLITNHQKT----VTSLSLASQGRRVVSGSLDGHVKVFETT 303 Score = 48.9 bits (115), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 42/159 (26%), Positives = 67/159 (42%), Gaps = 54/159 (33%) Query: 31 ILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFV---SDVVISSDGQFALSGSWDGTL 87 ++S S DKT+ +W L ++ P R GH+ +V + + S++ +SGS+D T+ Sbjct: 160 LMSCSDDKTVRLWDLPSND-----PTRLFTGHTDYVRCGAFMPGSANSNLLVSGSYDETV 214 Query: 88 RLWD----------------------LTTGTT-------------------TRRFVGHTK 106 R+WD L +GTT R H K Sbjct: 215 RVWDARAPGGAVMTFKHADPIEDVLPLPSGTTLLAASGNAISVLDLVAAKPLRLITNHQK 274 Query: 107 DVLSVAFSSDNRQIVSGSRDKTIKL-----WNTLGVCKY 140 V S++ +S R++VSGS D +K+ WN + KY Sbjct: 275 TVTSLSLASQGRRVVSGSLDGHVKVFETTSWNVVAGAKY 313 >3ACP-A nrPDB Length = 417 Score = 52.4 bits (124), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 32/86 (37%), Positives = 49/86 (56%), Gaps = 7/86 (8%) Query: 18 VTQIATTPQFP--DMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDG 75 V++I FP + ++S+S+D + +W + +D +N R L GH V+D+ I G Sbjct: 136 VSEITKLKFFPSGEALISSSQDMQLKIWSV-KDGSN----PRTLIGHRATVTDIAIIDRG 190 Query: 76 QFALSGSWDGTLRLWDLTTGTTTRRF 101 + LS S DGT+RLW+ TGTT F Sbjct: 191 RNVLSASLDGTIRLWECGTGTTIHTF 216 Score = 47.8 bits (112), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 22/84 (26%), Positives = 42/84 (50%) Query: 49 ETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDV 108 ++N+ + + + H ++ + G+ +S S D L++W + G+ R +GH V Sbjct: 122 DSNFNLQREIDQAHVSEITKLKFFPSGEALISSSQDMQLKIWSVKDGSNPRTLIGHRATV 181 Query: 109 LSVAFSSDNRQIVSGSRDKTIKLW 132 +A R ++S S D TI+LW Sbjct: 182 TDIAIIDRGRNVLSASLDGTIRLW 205 Score = 38.5 bits (88), Expect = 0.004, Method: Compositional matrix adjust. Identities = 47/221 (21%), Positives = 92/221 (41%), Gaps = 36/221 (16%) Query: 118 RQIVSGSRDKTIKLWNTLGVCKYTVQ---DESHSEWVSCVRFSPNSSNPIIVSCGWDKLV 174 R+ + G+ + IK+ ++ + +Q D++H ++ ++F P S ++S D + Sbjct: 107 RRFILGTTEGDIKVLDS----NFNLQREIDQAHVSEITKLKFFP--SGEALISSSQDMQL 160 Query: 175 KVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTL---- 230 K+W++ + IGH + + + G S DG LW+ G ++T Sbjct: 161 KIWSVKDGSNPRTLIGHRATVTDIAIIDRGRNVLSASLDGTIRLWECGTGTTIHTFNRKE 220 Query: 231 ---DGGDIINALCFSPNRYWLCAAT-----------GPSIKIWDLEGKIIVDEL--KQEV 274 DG + I AL +R +T G + + G I V + K++ Sbjct: 221 NPHDGVNSI-ALFVGTDRQLHEISTSKKNNLEFGTYGKYVIAGHVSGVITVHNVFSKEQT 279 Query: 275 ISTSSKAEPPQCTSLAWSADGQT---LFAGYTDNLVRVWQV 312 I SK C+ + + DG ++AGY + ++ W + Sbjct: 280 IQLPSKF---TCSCNSLTVDGNNANYIYAGYENGMLAQWDL 317 >5OQL-d nrPDB Length = 446 Score = 50.8 bits (120), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 37/116 (31%), Positives = 56/116 (48%), Gaps = 9/116 (7%) Query: 20 QIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFAL 79 +I P + AS D I ++ D N+ +GH V DV S G+ + Sbjct: 244 RIVFNPMEAMNLAVASEDHNIYIF----DARNFDKALNIQKGHVAAVMDVEFSPTGEELV 299 Query: 80 SGSWDGTLRLWDLTTGTTTRRFVGHTK---DVLSVAFSSDNRQIVSGSRDKTIKLW 132 SGS+D T+RLW G + R V HTK V ++ D++ I++GS D ++LW Sbjct: 300 SGSYDRTIRLWRRDAGHS--RDVYHTKRMQRVFRTMWTMDSKYILTGSDDGNVRLW 353 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 52/241 (21%), Positives = 94/241 (39%), Gaps = 14/241 (5%) Query: 80 SGSWDGTLRLWDLTT-GTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVC 138 SGS DG +++WDLTT T R H V + F++D ++++S + D IKLW+ Sbjct: 84 SGSGDGVVKVWDLTTRDEETWRVAAHNNIVKGLTFTND-KKLLSCATD-GIKLWDPYASP 141 Query: 139 KYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTV 198 T + E S + S + +++W+L + I +++T+ Sbjct: 142 SNTTPIATWQEGGPYTSLSFHRSANTFAASSGQGCIRIWDLEHS-TAGQAIQWPSFVDTI 200 Query: 199 T----VSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATGP 254 T + S+ S D +L+DL + N + F+P A Sbjct: 201 TDVCFNQVETSVIGSVATDRSIILFDLRTNMPVIKTVLHFACNRIVFNPMEAMNLAVASE 260 Query: 255 SIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTI 314 I+ + + L + K + +S G+ L +G D +R+W+ Sbjct: 261 DHNIYIFDARNFDKALNIQ------KGHVAAVMDVEFSPTGEELVSGSYDRTIRLWRRDA 314 Query: 315 G 315 G Sbjct: 315 G 315 Score = 36.6 bits (83), Expect = 0.016, Method: Compositional matrix adjust. Identities = 29/106 (27%), Positives = 50/106 (47%), Gaps = 10/106 (9%) Query: 30 MILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISS--DGQFALSGSWDGTL 87 +I S + D++II++ L TN + + L HF + ++ + + S D + Sbjct: 212 VIGSVATDRSIILFDL---RTNMPVIKTVL----HFACNRIVFNPMEAMNLAVASEDHNI 264 Query: 88 RLWDLTTGTTTRRF-VGHTKDVLSVAFSSDNRQIVSGSRDKTIKLW 132 ++D GH V+ V FS ++VSGS D+TI+LW Sbjct: 265 YIFDARNFDKALNIQKGHVAAVMDVEFSPTGEELVSGSYDRTIRLW 310 Score = 29.3 bits (64), Expect = 2.0, Method: Compositional matrix adjust. Identities = 45/222 (20%), Positives = 88/222 (39%), Gaps = 13/222 (5%) Query: 103 GHTKDVLSVAFSSDNRQ-IVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSS 161 GH + V S+ ++ I SGS D +K+W+ + T + +H+ V + F+ + Sbjct: 64 GHVQGVYSMCKDKNSLNCIASGSGDGVVKVWDLTTRDEETWRVAAHNNIVKGLTFTNDKK 123 Query: 162 NPIIVSCGWDKLVKVWNLANCKLKTNHIG---HTGYLNTVTVSPDGSLCASGGKDGQAML 218 ++SC D +K+W+ T I G +++ + A+ G + Sbjct: 124 ---LLSCATDG-IKLWDPYASPSNTTPIATWQEGGPYTSLSFHRSANTFAASSGQGCIRI 179 Query: 219 WDLNE---GKHLYTLDGGDIINALCFSPNRYWL--CAATGPSIKIWDLEGKIIVDELKQE 273 WDL G+ + D I +CF+ + AT SI ++DL + V + Sbjct: 180 WDLEHSTAGQAIQWPSFVDTITDVCFNQVETSVIGSVATDRSIILFDLRTNMPVIKTVLH 239 Query: 274 VISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIG 315 P + +LA +++ ++ N + + G Sbjct: 240 FACNRIVFNPMEAMNLAVASEDHNIYIFDARNFDKALNIQKG 281 >5BJS-A nrPDB Length = 605 Score = 50.4 bits (119), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 31/87 (35%), Positives = 44/87 (50%), Gaps = 1/87 (1%) Query: 7 LRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRD-ETNYGIPQRALRGHSHF 65 L TL GH G + +AT+P P +I SAS D TI +W L + E + GHS+ Sbjct: 170 LYRTLVGHGGGINDLATSPANPYIIASASDDTTIRIWSLAPEHEKQPCVCILGGEGHSYD 229 Query: 66 VSDVVISSDGQFALSGSWDGTLRLWDL 92 + V +G++ LS D + LW L Sbjct: 230 LLSVAFHDNGRYVLSAGHDQVINLWAL 256 Score = 47.8 bits (112), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 35/119 (29%), Positives = 52/119 (43%), Gaps = 19/119 (15%) Query: 57 RALRGHSHFVSDVVISSDGQFAL-SGSWDGTLRLWDLTTGTTTRRFV------GHTKDVL 109 R L GH ++D+ S + + S S D T+R+W L + V GH+ D+L Sbjct: 172 RTLVGHGGGINDLATSPANPYIIASASDDTTIRIWSLAPEHEKQPCVCILGGEGHSYDLL 231 Query: 110 SVAFSSDNRQIVSGSRDKTIKLWN---------TLGVCKYTVQ---DESHSEWVSCVRF 156 SVAF + R ++S D+ I LW + + Y E H+ V CV F Sbjct: 232 SVAFHDNGRYVLSAGHDQVINLWALPEFPNEHMEIPIVIYYPHFSSSEIHNNLVDCVAF 290 Score = 42.7 bits (99), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 39/159 (24%), Positives = 65/159 (40%), Gaps = 9/159 (5%) Query: 112 AFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWD 171 A +S ++ T K N + + D + + SC P + P++ G + Sbjct: 98 AATSKKHAVICRLTQTTDKDANPCEIIQLIRDDGNEANCASCWSKDPITDQPLLCIAGNE 157 Query: 172 KLVKVWNLANCKLKTNHIGHTGYLNTVTVSP-DGSLCASGGKDGQAMLWDL---NEGKHL 227 VKV+N+ KL +GH G +N + SP + + AS D +W L +E + Sbjct: 158 GNVKVYNVTEGKLYRTLVGHGGGINDLATSPANPYIIASASDDTTIRIWSLAPEHEKQPC 217 Query: 228 YTLDGG-----DIINALCFSPNRYWLCAATGPSIKIWDL 261 + GG D+++ RY L A I +W L Sbjct: 218 VCILGGEGHSYDLLSVAFHDNGRYVLSAGHDQVINLWAL 256 Score = 28.5 bits (62), Expect = 4.2, Method: Compositional matrix adjust. Identities = 22/72 (30%), Positives = 32/72 (44%), Gaps = 7/72 (9%) Query: 159 NSSNP-IIVSCGWDKLVKVWNLANCKLKTNHI------GHTGYLNTVTVSPDGSLCASGG 211 + +NP II S D +++W+LA K + GH+ L +V +G S G Sbjct: 187 SPANPYIIASASDDTTIRIWSLAPEHEKQPCVCILGGEGHSYDLLSVAFHDNGRYVLSAG 246 Query: 212 KDGQAMLWDLNE 223 D LW L E Sbjct: 247 HDQVINLWALPE 258 >5K19-A nrPDB Length = 569 Score = 49.3 bits (116), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 43/169 (25%), Positives = 72/169 (42%), Gaps = 17/169 (10%) Query: 66 VSDVVISSDGQFALSGSWDGTLRLWDLTT----GTTTRRFVGHTKDVLSVAFSSDNRQIV 121 +++ S DG+F S DG LR+++ + GT F G +L V +S D + IV Sbjct: 223 LNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGG----LLCVCWSPDGKYIV 278 Query: 122 SGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSS-----NPIIVSCGWDKLVKV 176 +G D + +W+ + C+ + H WVS V F P ++ +P+ S + + Sbjct: 279 TGGEDDLVTVWSFVD-CRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDL 337 Query: 177 WNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASG--GKDGQAMLWDLNE 223 + + + N+ P G G+D Q LWDL E Sbjct: 338 LHFGRDRANSTQ-SRLSKRNSTDSRPVSVTYRFGSVGQDTQLCLWDLTE 385 Score = 34.3 bits (77), Expect = 0.068, Method: Compositional matrix adjust. Identities = 42/204 (20%), Positives = 82/204 (40%), Gaps = 34/204 (16%) Query: 109 LSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSC 168 L V FS+ Q++ + +T KL+N + + D+S V+CV++ P S + +V+ Sbjct: 118 LLVGFSAGQVQLIDPIKKETSKLFN-----EERLIDKSR---VTCVKWVPGSESLFLVAH 169 Query: 169 GWDKLVKVWNLAN-CKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHL 227 + ++N+ + C H + V C S + W + EG Sbjct: 170 SSGNMY-LYNVEHTCGTTAPHYQLLKQGESFAVH----TCKSKSTRNPLLKWTVGEGA-- 222 Query: 228 YTLDGGDIINALCFSPN-RYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQC 286 +N FSP+ ++ C + +++++ + + +K Sbjct: 223 --------LNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGG---------L 265 Query: 287 TSLAWSADGQTLFAGYTDNLVRVW 310 + WS DG+ + G D+LV VW Sbjct: 266 LCVCWSPDGKYIVTGGEDDLVTVW 289 >5FA5-B nrPDB Length = 367 Score = 48.5 bits (114), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 34/105 (32%), Positives = 49/105 (46%), Gaps = 2/105 (1%) Query: 31 ILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLW 90 IL AS + +W+L +ET + + H VS V + S G A+SGS D +++W Sbjct: 119 ILVASDSGAVELWELDENETLI-VSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVW 177 Query: 91 DLTTGTTTRRFVGHTKDVLSVAFSSDNRQI-VSGSRDKTIKLWNT 134 DL + H V VA S + +S S D I LW+T Sbjct: 178 DLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDT 222 Score = 35.4 bits (80), Expect = 0.035, Method: Compositional matrix adjust. Identities = 34/110 (30%), Positives = 51/110 (46%), Gaps = 10/110 (9%) Query: 117 NRQIVSGSRDKTIKLWN-----TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWD 171 R I+ S ++LW TL V K+ + H + VS V S SS VS D Sbjct: 116 ERGILVASDSGAVELWELDENETLIVSKFCKYE--HDDIVSTV--SVLSSGTQAVSGSKD 171 Query: 172 KLVKVWNLANCKLKTNHIGHTGYLNTVTVSP-DGSLCASGGKDGQAMLWD 220 +KVW+LA + +++ H + V SP S+ S +D + +LWD Sbjct: 172 ICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWD 221 Score = 27.7 bits (60), Expect = 6.2, Method: Compositional matrix adjust. Identities = 26/104 (25%), Positives = 46/104 (44%), Gaps = 16/104 (15%) Query: 214 GQAMLWDLNEGKHLYT-----LDGGDIINAL-CFSPNRYWLCAATGPSIKIWDLEGKIIV 267 G LW+L+E + L + DI++ + S + + IK+WDL Sbjct: 126 GAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDL------ 179 Query: 268 DELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYT-DNLVRVW 310 Q+V+ +S +A Q T +A S ++F + DN + +W Sbjct: 180 ---AQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLW 220 >4YCZ-A nrPDB Length = 876 Score = 48.5 bits (114), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 65/255 (25%), Positives = 105/255 (41%), Gaps = 44/255 (17%) Query: 3 EQMTLRGTLKGHNGWVTQIA-TTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRG 61 E L TLKGH+G V ++ P++ +++ SA D +++W+ E N G QR Sbjct: 50 ETQRLTETLKGHDGAVWCVSWAHPKYGNILASAGYDGKVLIWR----ELN-GAWQRIFDF 104 Query: 62 HSHFVSDVVIS----SDGQFALSGSWDGTLRLWDLTTGTTTRR-FVGHTKDVLSVAF--- 113 H S V+S G S DG + + + + F H V SV++ Sbjct: 105 ALHKASVNVVSWSPHEAGCLLACASSDGNVSVLEFRDNSWEHSIFHAHGLGVNSVSWAPA 164 Query: 114 --------------SSDNRQIVSGSRDKTIKLWN-TLGVCKYTVQDES---HSEWVSCVR 155 S+ NR+ V+G D +K+W Y ++ E H++WV V Sbjct: 165 TSPGSIVSSKPGPKSTGNRRFVTGGSDNALKIWAYDPATNTYKLEREPLTGHTDWVRDVA 224 Query: 156 FSPNS-SNPIIVSCGWDKLVKVWNLA-------NCKLKTNHIGHTGYLNTVTVSPDGSLC 207 +SP I S D+ V++W NCK+ + + V+ S G++ Sbjct: 225 WSPTVLQKSYIASASEDRTVRIWTSDPANPLQWNCKV----LNFDAAVWRVSWSLSGNVL 280 Query: 208 ASGGKDGQAMLWDLN 222 A+ G D + LW N Sbjct: 281 AASGGDNKVTLWKEN 295 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 51/247 (20%), Positives = 95/247 (38%), Gaps = 32/247 (12%) Query: 92 LTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQD-ESHSEW 150 + GT GH + R++ + S D+TIK++ G + + + H Sbjct: 5 MAAGTQVIANSGHDDMIHDAVLDYYGRRLATCSSDRTIKIFEIEGETQRLTETLKGHDGA 64 Query: 151 VSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKT--NHIGHTGYLNTVTVSPD--GSL 206 V CV ++ I+ S G+D V +W N + + H +N V+ SP G L Sbjct: 65 VWCVSWAHPKYGNILASAGYDGKVLIWRELNGAWQRIFDFALHKASVNVVSWSPHEAGCL 124 Query: 207 CASGGKDGQAMLWDL--NEGKHLYTLDGGDIINALCFSP------------------NRY 246 A DG + + N +H G +N++ ++P NR Sbjct: 125 LACASSDGNVSVLEFRDNSWEHSIFHAHGLGVNSVSWAPATSPGSIVSSKPGPKSTGNRR 184 Query: 247 WLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSA---DGQTLFAGYT 303 ++ + ++KIW + +L++E ++ + +AWS + + Sbjct: 185 FVTGGSDNALKIWAYDPATNTYKLEREPLTGHTD----WVRDVAWSPTVLQKSYIASASE 240 Query: 304 DNLVRVW 310 D VR+W Sbjct: 241 DRTVRIW 247 >4OWR-A nrPDB Length = 339 Score = 48.5 bits (114), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 32/108 (29%), Positives = 53/108 (49%), Gaps = 8/108 (7%) Query: 75 GQFALSGSWDGTLRLWDLTTG--TTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLW 132 G F ++GSW +R W++ T + HT VL V +S D ++ + S DKT K+W Sbjct: 25 GNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMW 84 Query: 133 NTLGVCKYTVQDESHSEWVSCVRF--SPNSSNPIIVSCGWDKLVKVWN 178 + +Q H V + + +PN S +++ WDK +K W+ Sbjct: 85 DLSS--NQAIQIAQHDAPVKTIHWIKAPNYS--CVMTGSWDKTLKFWD 128 Score = 39.3 bits (90), Expect = 0.002, Method: Compositional matrix adjust. Identities = 30/115 (26%), Positives = 59/115 (51%), Gaps = 7/115 (6%) Query: 23 TTPQFP-DMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSG 81 + P P + +++ S + W++ ++ IP +A + H+ V DV S DG + Sbjct: 19 SPPTLPGNFLIAGSWANDVRCWEV--QDSGQTIP-KAQQMHTGPVLDVCWSDDGSKVFTA 75 Query: 82 SWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAF--SSDNRQIVSGSRDKTIKLWNT 134 S D T ++WDL++ + H V ++ + + + +++GS DKT+K W+T Sbjct: 76 SCDKTAKMWDLSSNQAI-QIAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWDT 129 Score = 32.0 bits (71), Expect = 0.41, Method: Compositional matrix adjust. Identities = 26/116 (22%), Positives = 48/116 (41%), Gaps = 6/116 (5%) Query: 151 VSCVRFSPNS-SNPIIVSCGWDKLVKVWNLANC--KLKTNHIGHTGYLNTVTVSPDGSLC 207 + C+ FSP + +++ W V+ W + + + HTG + V S DGS Sbjct: 13 IGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKV 72 Query: 208 ASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATG---PSIKIWD 260 + D A +WDL+ + + + + + + C TG ++K WD Sbjct: 73 FTASCDKTAKMWDLSSNQAIQIAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWD 128 >6ELZ-p nrPDB Length = 460 Score = 48.5 bits (114), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 24/69 (34%), Positives = 43/69 (62%), Gaps = 2/69 (2%) Query: 66 VSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSR 125 VS + + + +SGS+DG +R WDL +G +++ GH+ + +V + S+ R +VS Sbjct: 106 VSSLDVGDGSKHIISGSYDGIVRTWDL-SGNVQKQYSGHSGPIRAVKYISNTR-LVSAGN 163 Query: 126 DKTIKLWNT 134 D+T++LW T Sbjct: 164 DRTLRLWKT 172 Score = 39.3 bits (90), Expect = 0.002, Method: Compositional matrix adjust. Identities = 69/311 (22%), Positives = 104/311 (33%), Gaps = 117/311 (37%) Query: 31 ILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLW 90 I+S S D + W L+ G Q+ GHS + V S+ + +G+ D TLRLW Sbjct: 118 IISGSYDGIVRTWDLS------GNVQKQYSGHSGPIRAVKYISNTRLVSAGN-DRTLRLW 170 Query: 91 -----------------------DLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDK 127 ++ G T GH V+S+ S DN +I+S S D Sbjct: 171 KTKNDDLKLTSQQQAQEDDDDEVNIEDGKTLAILEGHKAPVVSIDVS-DNSRILSASYDN 229 Query: 128 TIKLWNTL-------------------------GVCKYTVQD------------ESHSEW 150 +I W+T+ K T++D ESH+ Sbjct: 230 SIGFWSTIYKEMTVVDPLEDINNPNNKISTAARKRRKLTMKDGTIRRRAPLSLLESHTAP 289 Query: 151 VSCVRFSPNSSNPIIVSCGWDKLVKVW--------------------------NLANCKL 184 V V F ++ N + S D +K W NL C Sbjct: 290 VEQVIFD-STDNTVGYSVSQDHTIKTWDLVTARCIDTRTTSYSLLSIAQLSTLNLLACGS 348 Query: 185 KTNH-------------------IGHTGYLNTVTVSPDGS--LCASGGKDGQAMLWDLNE 223 H IGH +++++ P+ LC SG DG +WD+ Sbjct: 349 SARHITLHDPRVGASSKVTQQQLIGHKNFVSSLDTCPENEYILC-SGSHDGTVKVWDVRS 407 Query: 224 GKHLYTLDGGD 234 +YT+ D Sbjct: 408 TSPMYTITRED 418 Score = 37.4 bits (85), Expect = 0.008, Method: Compositional matrix adjust. Identities = 27/86 (31%), Positives = 46/86 (53%), Gaps = 8/86 (9%) Query: 54 IPQRALRGHSHFVSDVVISSDGQFAL-SGSWDGTLRLWDLTTG----TTTRRFVGHTKDV 108 + Q+ L GH +FVS + + ++ L SGS DGT+++WD+ + T TR K V Sbjct: 366 VTQQQLIGHKNFVSSLDTCPENEYILCSGSHDGTVKVWDVRSTSPMYTITREDKSVQKGV 425 Query: 109 LSVAFS---SDNRQIVSGSRDKTIKL 131 F+ ++ I+S +DK I++ Sbjct: 426 NDKVFAVKWAEKVGIISAGQDKKIQI 451 Score = 33.5 bits (75), Expect = 0.13, Method: Compositional matrix adjust. Identities = 21/69 (30%), Positives = 36/69 (52%), Gaps = 5/69 (7%) Query: 117 NRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKV 176 ++ I+SGS D ++ W+ G + Q HS + V++ SN +VS G D+ +++ Sbjct: 115 SKHIISGSYDGIVRTWDLSGNVQK--QYSGHSGPIRAVKY---ISNTRLVSAGNDRTLRL 169 Query: 177 WNLANCKLK 185 W N LK Sbjct: 170 WKTKNDDLK 178 >6CHG-A nrPDB Length = 312 Score = 48.1 bits (113), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 44/172 (25%), Positives = 78/172 (45%), Gaps = 13/172 (7%) Query: 62 HSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIV 121 H ++ + S D + SGS D T+ + + G RR +GHT V+S+ +++ + Sbjct: 53 HKECINCLCWSPDSKCIASGSEDFTVEITHIIYGRI-RRLMGHTAPVISICYNNKGNILC 111 Query: 122 SGSRDKTIKLWNTL-GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWN-- 178 S S D++IK W+ L G T+ +HS+ V + P + I+ S +D L+++++ Sbjct: 112 SSSMDESIKEWHVLSGTALKTMS--AHSDAVVSIDI-PKFDSSILSSGSYDGLIRIFDTE 168 Query: 179 ----LANCKLKTNHIGHTGY--LNTVTVSPDGSLCASGGKDGQAMLWDLNEG 224 L + I G ++TV S +G D LW+ G Sbjct: 169 SGHCLKTLTYDKDWIAEDGVVPISTVKFSRNGKFLLVKSLDNVVKLWEYTRG 220 Score = 43.9 bits (102), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 36/131 (27%), Positives = 64/131 (48%), Gaps = 14/131 (10%) Query: 57 RALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSS- 115 R L GH+ V + ++ G S S D +++ W + +GT + H+ V+S+ Sbjct: 89 RRLMGHTAPVISICYNNKGNILCSSSMDESIKEWHVLSGTALKTMSAHSDAVVSIDIPKF 148 Query: 116 DNRQIVSGSRDKTIKLWNTL-GVCKYTVQDESHSEW--------VSCVRFSPNSSNPIIV 166 D+ + SGS D I++++T G C T+ + +W +S V+FS N ++ Sbjct: 149 DSSILSSGSYDGLIRIFDTESGHCLKTLTYD--KDWIAEDGVVPISTVKFSRNGKFLLVK 206 Query: 167 SCGWDKLVKVW 177 S D +VK+W Sbjct: 207 S--LDNVVKLW 215 Score = 37.7 bits (86), Expect = 0.006, Method: Compositional matrix adjust. Identities = 49/248 (19%), Positives = 103/248 (41%), Gaps = 49/248 (19%) Query: 71 ISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIK 130 IS DG+ ++ + + ++++++ + H + + + +S D++ I SGS D T++ Sbjct: 21 ISPDGEL-IAICQNTDMLVYEISSSKMMKLTTTHKECINCLCWSPDSKCIASGSEDFTVE 79 Query: 131 LWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWN-LANCKLKTNHI 189 + + + Y + N+ I+ S D+ +K W+ L+ LKT Sbjct: 80 ITHII----YGRIRRLMGHTAPVISICYNNKGNILCSSSMDESIKEWHVLSGTALKTMS- 134 Query: 190 GHTGYLNTVTVSP-DGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWL 248 H+ + ++ + D S+ +SG DG ++D G L TL + ++ W+ Sbjct: 135 AHSDAVVSIDIPKFDSSILSSGSYDGLIRIFDTESGHCLKTL-----------TYDKDWI 183 Query: 249 CAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVR 308 +G + + +K +S +G+ L DN+V+ Sbjct: 184 AE-----------DGVVPISTVK-------------------FSRNGKFLLVKSLDNVVK 213 Query: 309 VWQVTIGT 316 +W+ T GT Sbjct: 214 LWEYTRGT 221 Score = 36.2 bits (82), Expect = 0.019, Method: Compositional matrix adjust. Identities = 36/135 (26%), Positives = 58/135 (42%), Gaps = 25/135 (18%) Query: 66 VSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFV-GHTKDVLSVAFSS--------- 115 +S V S +G+F L S D ++LW+ T GT R F+ H + + ++ Sbjct: 191 ISTVKFSRNGKFLLVKSLDNVVKLWEYTRGTVVRTFLWPHQETKAKLKYNCGLELIYPQG 250 Query: 116 DNRQIVSGSRDKTIKLWNTLGVCKYTVQ--DESHSEWVSCVRFSPNSSNPIIVSCGWDKL 173 + ++SG+ ++ +WN K VQ DE H R SP I +S +DK+ Sbjct: 251 KDPLVISGNDSGSMCVWNVYS--KNLVQKIDEKH-------RNSP----LISISASYDKV 297 Query: 174 VKVWNLANCKLKTNH 188 + C L H Sbjct: 298 ATLSLNGECNLFRVH 312 >2HES-X nrPDB Length = 330 Score = 48.1 bits (113), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 60/244 (24%), Positives = 99/244 (40%), Gaps = 29/244 (11%) Query: 2 TEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRG 61 T +M L ++GH V +A + + + SRDK++ +W+ Y L+ Sbjct: 94 TFEMDLLAIIEGHENEVKGVAWSNDGY-YLATCSRDKSVWIWETDESGEEYECIS-VLQE 151 Query: 62 HSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTG--TTTRRFVGHTKDVLSVAFSSDN-- 117 HS V V+ S S+D T+R+W GH V S F Sbjct: 152 HSQDVKHVIWHPSEALLASSSYDDTVRIWKDYDDDWECVAVLNGHEGTVWSSDFDKTEGV 211 Query: 118 RQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSS-----------NPIIV 166 ++ SGS D T+++W +G ++ EWV C P+ N +I Sbjct: 212 FRLCSGSDDSTVRVWKYMG-----DDEDDQQEWV-CEAILPDVHKRQVYNVAWGFNGLIA 265 Query: 167 SCGWDKLVKVWNLANCKLKT---NHIGHTGY-LNTVT-VSPDG-SLCASGGKDGQAMLWD 220 S G D ++ V+ + + K + H Y +N V + +G ++ A+GG DG W Sbjct: 266 SVGADGVLAVYEEVDGEWKVFAKRALCHGVYEINVVKWLELNGKTILATGGDDGIVNFWS 325 Query: 221 LNEG 224 L + Sbjct: 326 LEKA 329 Score = 38.1 bits (87), Expect = 0.005, Method: Compositional matrix adjust. Identities = 32/112 (28%), Positives = 54/112 (48%), Gaps = 18/112 (16%) Query: 80 SGSWDGTLRLWDLTTGTTTRRFV--------GHTKDVLSVAFSSDNRQIVSGSRDKTIKL 131 +GS+D T+ +W + R F GH +V VA+S+D + + SRDK++ + Sbjct: 75 AGSFDSTVSIW-AKEESADRTFEMDLLAIIEGHENEVKGVAWSNDGYYLATCSRDKSVWI 133 Query: 132 WNT-----LGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWN 178 W T C +Q+ HS+ V V + P S ++ S +D V++W Sbjct: 134 WETDESGEEYECISVLQE--HSQDVKHVIWHP--SEALLASSSYDDTVRIWK 181 Score = 34.7 bits (78), Expect = 0.055, Method: Compositional matrix adjust. Identities = 28/127 (22%), Positives = 54/127 (42%), Gaps = 7/127 (5%) Query: 13 GHNGWVTQIATTPQFPDMILSASRDKTIIMW--KLTRDETNYGIPQRALRGHSHFVSDVV 70 H + +A P ++ + S D T+ +W + + D T + GH + V V Sbjct: 56 AHKKAIRSVAWRPH-TSLLAAGSFDSTVSIWAKEESADRTFEMDLLAIIEGHENEVKGVA 114 Query: 71 ISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVG----HTKDVLSVAFSSDNRQIVSGSRD 126 S+DG + + S D ++ +W+ + H++DV V + + S S D Sbjct: 115 WSNDGYYLATCSRDKSVWIWETDESGEEYECISVLQEHSQDVKHVIWHPSEALLASSSYD 174 Query: 127 KTIKLWN 133 T+++W Sbjct: 175 DTVRIWK 181 Score = 30.0 bits (66), Expect = 1.5, Method: Compositional matrix adjust. Identities = 27/120 (22%), Positives = 53/120 (44%), Gaps = 14/120 (11%) Query: 120 IVSGSRDKTIKLWNTLGVCKYTVQD----ESHSEWVSCVRFSPNSSNPIIVSCGWDKLVK 175 + +GS D+ IKL ++ +T+ D +H + + V + P++S ++ + +D V Sbjct: 27 LATGSTDRKIKL-VSVKYDDFTLIDVLDETAHKKAIRSVAWRPHTS--LLAAGSFDSTVS 83 Query: 176 VWNLANCKLKTNHI-------GHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLY 228 +W +T + GH + V S DG A+ +D +W+ +E Y Sbjct: 84 IWAKEESADRTFEMDLLAIIEGHENEVKGVAWSNDGYYLATCSRDKSVWIWETDESGEEY 143 >5WLC-LJ nrPDB Length = 513 Score = 47.8 bits (112), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 56/235 (23%), Positives = 102/235 (43%), Gaps = 25/235 (10%) Query: 3 EQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGH 62 Q T +K HN VT I+ PQ P S + I TR + ++ Sbjct: 28 RQYTSAQLVKEHNS-VTHISFNPQHPHDFAVTSSTRVQIFSSRTR---------QVIKTF 77 Query: 63 SHFVSDVVIS----SDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVA--FSSD 116 S F DVV S SDG+ +G G + ++D T + + V + D Sbjct: 78 SRF-KDVVYSASFRSDGKLLCAGDATGLVSVYDSYNPRTILLSINASTHPTHVTKFHTQD 136 Query: 117 NRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCG-WDKLVK 175 N+ + + S D+ +LW+ + ++ +++V + F P + P +V+ G +D L++ Sbjct: 137 NKILATASDDRVTRLWDISNAYEPQLELTGATDYVRTLSFIP--AAPHLVATGSYDGLIR 194 Query: 176 VWNL-ANCKLKTNHIGHTGYL-NTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLY 228 +++ ++ + H + N + VSP + + GG + + +WDL K LY Sbjct: 195 LYDTRSSGSTPIYSLNHDQPVENVIAVSP-TQIVSCGGNNFK--VWDLTSNKKLY 246 >5WYJ-BE nrPDB Length = 939 Score = 47.4 bits (111), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 45/203 (22%), Positives = 84/203 (41%), Gaps = 18/203 (8%) Query: 65 FVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGS 124 FV V +S G F GS +G++ ++++ +G +++ H + V ++ NR++VS Sbjct: 462 FVKSVAMSQCGNFGFIGSSNGSITIYNMQSGILRKKYKLHKRAVTGISLDGMNRKMVSCG 521 Query: 125 RDKTIKLWN-----TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKL-VKVWN 178 D + ++ LG K ++ + + +S + + D L + V + Sbjct: 522 LDGIVGFYDFNKSTLLGKLKLDAP-------ITAMVYHRSSD---LFALALDDLSIVVID 571 Query: 179 LANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINA 238 ++ GH+ + SP+G S D WDL G + + ++ Sbjct: 572 AVTQRVVRQLWGHSNRITAFDFSPEGRWIVSASLDSTIRTWDLPTGGCIDGIIVDNVATN 631 Query: 239 LCFSPNRYWLCA--ATGPSIKIW 259 + FSPN L TG I IW Sbjct: 632 VKFSPNGDLLATTHVTGNGICIW 654 Score = 38.1 bits (87), Expect = 0.005, Method: Compositional matrix adjust. Identities = 70/298 (23%), Positives = 119/298 (39%), Gaps = 36/298 (12%) Query: 13 GHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGH---------- 62 GH+ + IA +LSAS+D+++ + L +D + + QR + Sbjct: 348 GHSQPPSYIAFADSQSHFMLSASKDRSLWSFSLRKDAQSQEMSQRLHKKQDGGRVGGSTI 407 Query: 63 -SHFVSDVVISSDGQFALSGSWDGTL---------RLWDLTTGTTTRRFVGHTKD--VLS 110 S F V ++ + A G W+ + R WD+ R T D V S Sbjct: 408 KSKFPEIVALAIEN--ARIGEWENIITAHKDEKFARTWDMRNKRVGRWTFDTTDDGFVKS 465 Query: 111 VAFSSDNRQIVSGSRDKTIKLWNTL-GVC--KYTVQDESHSEWVSCVRFSPNSSNPIIVS 167 VA S GS + +I ++N G+ KY + H V+ + S + N +VS Sbjct: 466 VAMSQCGNFGFIGSSNGSITIYNMQSGILRKKYKL----HKRAVTGI--SLDGMNRKMVS 519 Query: 168 CGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHL 227 CG D +V ++ L + + + L A D ++ D + + Sbjct: 520 CGLDGIVGFYDFNKSTL-LGKLKLDAPITAMVYHRSSDLFALALDDLSIVVIDAVTQRVV 578 Query: 228 YTLDG-GDIINALCFSPNRYWLCAATGPS-IKIWDLEGKIIVDELKQEVISTSSKAEP 283 L G + I A FSP W+ +A+ S I+ WDL +D + + ++T+ K P Sbjct: 579 RQLWGHSNRITAFDFSPEGRWIVSASLDSTIRTWDLPTGGCIDGIIVDNVATNVKFSP 636 >4PSX-B nrPDB Length = 401 Score = 47.4 bits (111), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 54/220 (24%), Positives = 102/220 (46%), Gaps = 19/220 (8%) Query: 14 HNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISS 73 H +T+ PQ P+++ + + T ++ +R E G+ Q L+ H + S+ Sbjct: 117 HEEEITRARYMPQDPNIVATINGQGTTFLY--SRSE---GL-QSTLKFHKDNGYALSFST 170 Query: 74 --DGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSD-----NRQIVSGSRD 126 G+ LSGS D T+ LW++ +G + V D+ S + + N+ + + Sbjct: 171 LVKGRL-LSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSE 229 Query: 127 KTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKT 186 ++ N + T+ + + + FS +SSN ++ + G D V +++L N K Sbjct: 230 DSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSN-LLAAAGMDSYVYLYDLRNMKEPL 288 Query: 187 NHI-GHTGYLNTVTVSP--DGSLCASGGKDGQAMLWDLNE 223 +H+ GH +N + S DG + S G D + M+WDL + Sbjct: 289 HHMSGHEDAVNNLEFSTHVDG-VVVSSGSDNRLMMWDLKQ 327 >5OQL-X nrPDB Length = 630 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 36/136 (26%), Positives = 57/136 (41%), Gaps = 7/136 (5%) Query: 101 FVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNT--LGVCKYTVQDESHSEWVSCVRFSP 158 + GH K L V S D + +V+G DK + ++N L K Q H + V+ + F Sbjct: 242 YQGHLKAPLVVKASQDGKFVVTGGADKRLVVYNAADLKPIKAFTQ---HRDAVTGLAFRR 298 Query: 159 NSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAML 218 ++ + SC D+ VKVW+L GH + + + G +D A Sbjct: 299 GTNQ--LYSCSKDRTVKVWSLDELAYVETLFGHQDEILDIDALGQERCVSVGARDRTARY 356 Query: 219 WDLNEGKHLYTLDGGD 234 W + E L GG+ Sbjct: 357 WKVPEESQLVFRGGGE 372 Score = 44.3 bits (103), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 56/284 (19%), Positives = 100/284 (35%), Gaps = 49/284 (17%) Query: 57 RALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSD 116 + +GH V S DG+F ++G D L +++ + F H V +AF Sbjct: 240 KTYQGHLKAPLVVKASQDGKFVVTGGADKRLVVYNAADLKPIKAFTQHRDAVTGLAFRRG 299 Query: 117 NRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKV 176 Q+ S S+D+T+K+W +L Y H + + + + D+ + Sbjct: 300 TNQLYSCSKDRTVKVW-SLDELAYVETLFGHQDEI--LDIDALGQERCVSVGARDRTARY 356 Query: 177 WNL----------------ANCK-------LKTNHIGHTGYLNTVTVSPDGSLCASGGKD 213 W + +N K + H G ++ V + D + +G + Sbjct: 357 WKVPEESQLVFRGGGEGGSSNTKKHKLPPGMDPASAAHEGSMDRVAMI-DDDMFVTGSDN 415 Query: 214 GQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQE 273 G LW + K L+ + + P IK+ D I D Sbjct: 416 GDLALWSIQRKKPLHVIARAHGLE----------------PPIKLEDYSADEIPDP---- 455 Query: 274 VISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGTR 317 S +P T+L +F+G D +RVW+++ R Sbjct: 456 --SIIPAPQPRGITALRTLPYSDLIFSGSWDGCIRVWRLSEDKR 497 Score = 27.7 bits (60), Expect = 6.6, Method: Compositional matrix adjust. Identities = 47/213 (22%), Positives = 76/213 (35%), Gaps = 55/213 (25%) Query: 29 DMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLR 88 + + S S+D+T+ +W L DE Y L GH + D+ + G+ D T R Sbjct: 301 NQLYSCSKDRTVKVWSL--DELAY---VETLFGHQDEILDIDALGQERCVSVGARDRTAR 355 Query: 89 LWDLT--------------TGTTTRRFVGHTKDVLSVAFSS--------DNRQIVSGSRD 126 W + + T + + D S A D+ V+GS + Sbjct: 356 YWKVPEESQLVFRGGGEGGSSNTKKHKLPPGMDPASAAHEGSMDRVAMIDDDMFVTGSDN 415 Query: 127 KTIKLWN-----TLGVCKYT--------VQDESHSE-------------WVSCVRFSPNS 160 + LW+ L V ++D S E ++ +R P S Sbjct: 416 GDLALWSIQRKKPLHVIARAHGLEPPIKLEDYSADEIPDPSIIPAPQPRGITALRTLPYS 475 Query: 161 SNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTG 193 +I S WD ++VW L+ K K +G G Sbjct: 476 D--LIFSGSWDGCIRVWRLSEDKRKLEAVGILG 506 >4BH6-A nrPDB Length = 308 Score = 46.6 bits (109), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 57/244 (23%), Positives = 97/244 (39%), Gaps = 19/244 (7%) Query: 75 GQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNT 134 G G +G + ++D+ R GH V S +N + SGSRD I + Sbjct: 74 GSHLAVGQANGLVEIYDVMKRKCIRTLSGHIDRV--ACLSWNNHVLTSGSRDHRILHRDV 131 Query: 135 LGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGY 194 + ESH++ V +++ N ++ + S G D +V V+ + H Sbjct: 132 RMPDPFFETIESHTQEVCGLKW--NVADNKLASGGNDNVVHVYEGTSKSPILTFDEHKAA 189 Query: 195 LNTVTVSPD--GSLCASGG-KDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAA 251 + + SP G L GG D + +W++N + +D G I + +S N L + Sbjct: 190 VKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDIDSGSQICNMVWSKNTNELVTS 249 Query: 252 TGPS---IKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVR 308 G S + +WD + LK + L S DG T+ +G D +R Sbjct: 250 HGYSKYNLTLWDCNSMDPIAILKGHSF---------RVLHLTLSNDGTTVVSGAGDETLR 300 Query: 309 VWQV 312 W++ Sbjct: 301 YWKL 304 Score = 38.5 bits (88), Expect = 0.004, Method: Compositional matrix adjust. Identities = 49/216 (22%), Positives = 89/216 (41%), Gaps = 14/216 (6%) Query: 10 TLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDV 69 TL GH + ++A ++ S SRD I L RD + H+ V + Sbjct: 99 TLSGH---IDRVACLSWNNHVLTSGSRDHRI----LHRDVRMPDPFFETIESHTQEVCGL 151 Query: 70 VISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVS---GSRD 126 + SG D + +++ T+ + F H V ++A+S R +++ G+ D Sbjct: 152 KWNVADNKLASGGNDNVVHVYEGTSKSPILTFDEHKAAVKAMAWSPHKRGVLATGGGTAD 211 Query: 127 KTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKL-VKVWNLANCKLK 185 + +K+WN K + D C ++N ++ S G+ K + +W+ + Sbjct: 212 RRLKIWNVNTSIKMSDIDSGSQ---ICNMVWSKNTNELVTSHGYSKYNLTLWDCNSMDPI 268 Query: 186 TNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDL 221 GH+ + +T+S DG+ SG D W L Sbjct: 269 AILKGHSFRVLHLTLSNDGTTVVSGAGDETLRYWKL 304 >5M89-A nrPDB Length = 329 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 55/233 (23%), Positives = 97/233 (41%), Gaps = 33/233 (14%) Query: 78 ALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSD--NRQIVSGSRDKTIKLWNTL 135 A G DG L ++ + R T D+ +++ ++V G+ +K+++ Sbjct: 66 AAVGGLDGKLDIYSVVANKVER-----TLDIGEPVTATEWTGTKVVIGTAKGWVKVYD-- 118 Query: 136 GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGY- 194 + + ++H+ V+ + P I+ S G DK ++L +T GY Sbjct: 119 -AGRESATFQTHAGPVTGLAVHPGGR--ILASVGVDKSFVFYDL-----ETGERVARGYA 170 Query: 195 ---LNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAA 251 L T PDG+L A+G + G +++ + + G I AL FS N +W AA Sbjct: 171 DAALTTCAFHPDGNLFAAGTQTGHILVFHTTTLEQAESFPLGTPIQALAFSENGFWF-AA 229 Query: 252 TGP---SIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAG 301 TG S+ I+DL K + + + + S++W GQ L G Sbjct: 230 TGKGTSSVTIFDLR--------KSGAAAAVKELQTGEVLSISWDYTGQYLATG 274 >5A31-R nrPDB Length = 386 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 57/244 (23%), Positives = 97/244 (39%), Gaps = 19/244 (7%) Query: 75 GQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNT 134 G G +G + ++D+ R GH V S +N + SGSRD I + Sbjct: 143 GSHLAVGQANGLVEIYDVMKRKCIRTLSGHIDRV--ACLSWNNHVLTSGSRDHRILHRDV 200 Query: 135 LGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGY 194 + ESH++ V +++ N ++ + S G D +V V+ + H Sbjct: 201 RMPDPFFETIESHTQEVCGLKW--NVADNKLASGGNDNVVHVYEGTSKSPILTFDEHKAA 258 Query: 195 LNTVTVSPD--GSLCASGG-KDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAA 251 + + SP G L GG D + +W++N + +D G I + +S N L + Sbjct: 259 VKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDIDSGSQICNMVWSKNTNELVTS 318 Query: 252 TGPS---IKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVR 308 G S + +WD + LK + L S DG T+ +G D +R Sbjct: 319 HGYSKYNLTLWDCNSMDPIAILKGHSF---------RVLHLTLSNDGTTVVSGAGDETLR 369 Query: 309 VWQV 312 W++ Sbjct: 370 YWKL 373 Score = 37.7 bits (86), Expect = 0.007, Method: Compositional matrix adjust. Identities = 49/216 (22%), Positives = 89/216 (41%), Gaps = 14/216 (6%) Query: 10 TLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDV 69 TL GH + ++A ++ S SRD I L RD + H+ V + Sbjct: 168 TLSGH---IDRVACLSWNNHVLTSGSRDHRI----LHRDVRMPDPFFETIESHTQEVCGL 220 Query: 70 VISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVS---GSRD 126 + SG D + +++ T+ + F H V ++A+S R +++ G+ D Sbjct: 221 KWNVADNKLASGGNDNVVHVYEGTSKSPILTFDEHKAAVKAMAWSPHKRGVLATGGGTAD 280 Query: 127 KTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKL-VKVWNLANCKLK 185 + +K+WN K + D C ++N ++ S G+ K + +W+ + Sbjct: 281 RRLKIWNVNTSIKMSDIDSGSQ---ICNMVWSKNTNELVTSHGYSKYNLTLWDCNSMDPI 337 Query: 186 TNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDL 221 GH+ + +T+S DG+ SG D W L Sbjct: 338 AILKGHSFRVLHLTLSNDGTTVVSGAGDETLRYWKL 373 Score = 34.3 bits (77), Expect = 0.082, Method: Compositional matrix adjust. Identities = 17/51 (33%), Positives = 26/51 (50%) Query: 87 LRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGV 137 L LWD + GH+ VL + S+D +VSG+ D+T++ W V Sbjct: 326 LTLWDCNSMDPIAILKGHSFRVLHLTLSNDGTTVVSGAGDETLRYWKLFDV 376 >4A11-B nrPDB Length = 408 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 63/254 (24%), Positives = 109/254 (42%), Gaps = 43/254 (16%) Query: 74 DGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWN 133 +G++ LSG DG + L+DL ++R+ K V S+ RD Sbjct: 55 EGRYMLSGGSDGVIVLYDLEN--SSRQSYYTCKAVCSIG------------RD------- 93 Query: 134 TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCK-LKTNHIGHT 192 + H V V++ P+ + + S +DK +KVW+ + + T Sbjct: 94 ---------HPDVHRYSVETVQWYPHDTG-MFTSSSFDKTLKVWDTNTLQTADVFNFEET 143 Query: 193 GYLNTVT-VSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGG-DIINALCFSPNR-YWLC 249 Y + ++ VS L A G + + L DL G + L G I A+ +SP Y L Sbjct: 144 VYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILA 203 Query: 250 AATGPS-IKIWDLEGK----IIVDE---LKQEVISTSSKAEPPQCTSLAWSADGQTLFAG 301 A+ S +K+WD+ I +D+ K + + +++ A + L +++DG L Sbjct: 204 TASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTV 263 Query: 302 YTDNLVRVWQVTIG 315 TDN +R+W + G Sbjct: 264 GTDNRMRLWNSSNG 277 Score = 38.1 bits (87), Expect = 0.005, Method: Compositional matrix adjust. Identities = 54/248 (21%), Positives = 100/248 (40%), Gaps = 33/248 (13%) Query: 8 RGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRAL----RGHS 63 R + H G + + P +LS D I+++ L +A+ R H Sbjct: 36 RDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHP 95 Query: 64 --HFVSDVVIS---SDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLS---VAFSS 115 H S + D S S+D TL++WD T T F + V S S+ Sbjct: 96 DVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVF-NFEETVYSHHMSPVST 154 Query: 116 DNRQIVSGSRDKTIKLWN-TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLV 174 + + G+R ++L + G C + +Q H + + V +SP + I+ + D V Sbjct: 155 KHCLVAVGTRGPKVQLCDLKSGSCSHILQ--GHRQEILAVSWSPRY-DYILATASADSRV 211 Query: 175 KVWNL---ANC-------------KLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAML 218 K+W++ + C +++ + H G +N + + DG + G D + L Sbjct: 212 KLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRL 271 Query: 219 WDLNEGKH 226 W+ + G++ Sbjct: 272 WNSSNGEN 279 Score = 37.0 bits (84), Expect = 0.010, Method: Compositional matrix adjust. Identities = 40/181 (22%), Positives = 68/181 (37%), Gaps = 60/181 (33%) Query: 11 LKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTR--------DETNYGIPQRALR-- 60 L+GH + ++ +P++ ++ +AS D + +W + R D+ N G +A+ Sbjct: 182 LQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHN-GKKSQAVESA 240 Query: 61 --GHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTT-------------------- 98 H+ V+ + +SDG L+ D +RLW+ + G T Sbjct: 241 NTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVS 300 Query: 99 ----RRFV-----------------------GHTKDVLSVAFSSDNRQIVSGSRDKTIKL 131 FV GH K V F S+ +++ SGSRD I Sbjct: 301 CGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILA 360 Query: 132 W 132 W Sbjct: 361 W 361 >4J0X-A nrPDB Length = 451 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 36/134 (26%), Positives = 61/134 (45%), Gaps = 6/134 (4%) Query: 103 GHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNT--LGVCKYTVQDESHSEWVSCVRFSPNS 160 GH ++L+VA S D + +V+G RD+ + +W+T L K + E +S F N Sbjct: 112 GHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRRGEVLSLA-FRKN- 169 Query: 161 SNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWD 220 S+ + SC D ++ +++ GH + ++ G +D AMLW Sbjct: 170 SDQLYASCA-DFKIRTYSINQFSQLEILYGHHDIVEDISALAMERCVTVGARDRTAMLWK 228 Query: 221 LNEGKHLYTLDGGD 234 + + L T GGD Sbjct: 229 IPDETRL-TFRGGD 241 Score = 38.5 bits (88), Expect = 0.004, Method: Compositional matrix adjust. Identities = 50/266 (18%), Positives = 100/266 (37%), Gaps = 18/266 (6%) Query: 2 TEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRG 61 T + T +GH + +A +P +++ RD+ +I+W IP + RG Sbjct: 101 TSKHEYENTTEGHYDEILTVAASPD-GKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRRG 159 Query: 62 HSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIV 121 V + + + D +R + + + GH V ++ + R + Sbjct: 160 E---VLSLAFRKNSDQLYASCADFKIRTYSINQFSQLEILYGHHDIVEDISALAMERCVT 216 Query: 122 SGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLAN 181 G+RD+T LW + T + + + N+ G D VK + + Sbjct: 217 VGARDRTAMLWKIPDETRLTFRGGDEPQKLLRRWMKENAKE------GEDGEVKYPDESE 270 Query: 182 CKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCF 241 L G ++ V++ D +G +G LW L + K ++T I + + Sbjct: 271 APL----FFCEGSIDVVSMVDDFHFI-TGSDNGNICLWSLAKKKPIFT---ERIAHGILP 322 Query: 242 SPNRYWLCAATGPSIKIWDLEGKIIV 267 P+ + T ++ L+GK ++ Sbjct: 323 EPSFNDISGETDEELRKRQLQGKKLL 348 >4U1E-I nrPDB Length = 347 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 45/177 (25%), Positives = 75/177 (42%), Gaps = 12/177 (6%) Query: 147 HSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSL 206 H ++ V++ N ++ SC D VW N + GHTG + ++ V Sbjct: 9 HERPLTQVKY--NKEGDLLFSCSKDSSASVWYSLNGERLGTLDGHTGTIWSIDVDCFTKY 66 Query: 207 CASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSP-NRYWLC----AATGP-SIKIWD 260 C +G D LWD++ G+ + T + + FSP Y+L P SI I++ Sbjct: 67 CVTGSADYSIKLWDVSNGQCVATWKSPVPVKRVEFSPCGNYFLAILDNVMKNPGSINIYE 126 Query: 261 LEGKIIVDEL---KQEVISTSSKAEPPQCTSLA-WSADGQTLFAGYTDNLVRVWQVT 313 +E EL +E I E ++A WS G+ + AG+ D + + V+ Sbjct: 127 IERDSATHELTKVSEEPIHKIITHEGLDAATVAGWSTKGKYIIAGHKDGKISKYDVS 183 Score = 38.9 bits (89), Expect = 0.003, Method: Compositional matrix adjust. Identities = 43/175 (24%), Positives = 69/175 (39%), Gaps = 19/175 (10%) Query: 72 SSDGQFALSGSWDGTLRLWDLTTGTTTRRFVG-HTKDVLSVAFSSDNRQIVSGSRDKTIK 130 S+ G++ ++G DG + +D++ + H K + + FS D ++ SRD Sbjct: 162 STKGKYIIAGHKDGKISKYDVSNNYEYVDSIDLHEKSISDMQFSPDLTYFITSSRDTNSF 221 Query: 131 LWN--TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNH 188 L + TL V K D ++ +P I+ K V + K + Sbjct: 222 LVDVSTLQVLKKYETDCP----LNTAVITPLKEFIILGGGQEAKDVTTTSANEGKFEARF 277 Query: 189 I------------GHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLD 231 GH G LNTV +SP G+ ASGG+DG L + + D Sbjct: 278 YHKIFEEEIGRVQGHFGPLNTVAISPQGTSYASGGEDGFIRLHHFEKSYFDFKYD 332 Score = 38.5 bits (88), Expect = 0.004, Method: Compositional matrix adjust. Identities = 28/76 (36%), Positives = 39/76 (51%), Gaps = 6/76 (7%) Query: 190 GHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG--GDI--INALCFSPNR 245 GH L V + +G L S KD A +W G+ L TLDG G I I+ CF+ + Sbjct: 8 GHERPLTQVKYNKEGDLLFSCSKDSSASVWYSLNGERLGTLDGHTGTIWSIDVDCFT--K 65 Query: 246 YWLCAATGPSIKIWDL 261 Y + + SIK+WD+ Sbjct: 66 YCVTGSADYSIKLWDV 81 Score = 37.0 bits (84), Expect = 0.012, Method: Compositional matrix adjust. Identities = 55/215 (25%), Positives = 90/215 (41%), Gaps = 26/215 (12%) Query: 59 LRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNR 118 L GH ++ V + +G S S D + +W G GHT + S+ + Sbjct: 6 LTGHERPLTQVKYNKEGDLLFSCSKDSSASVWYSLNGERLGTLDGHTGTIWSIDVDCFTK 65 Query: 119 QIVSGSRDKTIKLWN-TLGVCKYTVQDE---SHSEWVSC----------VRFSPNSSN-- 162 V+GS D +IKLW+ + G C T + E+ C V +P S N Sbjct: 66 YCVTGSADYSIKLWDVSNGQCVATWKSPVPVKRVEFSPCGNYFLAILDNVMKNPGSINIY 125 Query: 163 PIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTV---SPDGSLCASGGKDGQAMLW 219 I +L KV K+ I H G L+ TV S G +G KDG+ + Sbjct: 126 EIERDSATHELTKVSEEPIHKI----ITHEG-LDAATVAGWSTKGKYIIAGHKDGKISKY 180 Query: 220 DL-NEGKHLYTLDGGDI-INALCFSPNRYWLCAAT 252 D+ N +++ ++D + I+ + FSP+ + ++ Sbjct: 181 DVSNNYEYVDSIDLHEKSISDMQFSPDLTYFITSS 215 >5WLC-LU nrPDB Length = 489 Score = 45.8 bits (107), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 26/79 (32%), Positives = 43/79 (54%), Gaps = 5/79 (6%) Query: 59 LRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTK---DVLSVAFSS 115 + H V DV S G ++GS+D ++R++ G + R + HTK V V +S Sbjct: 301 FKDHVSAVMDVDFSPTGDEIVTGSYDKSIRIYKTNHGHS--REIYHTKRMQHVFQVKYSM 358 Query: 116 DNRQIVSGSRDKTIKLWNT 134 D++ I+SGS D ++LW + Sbjct: 359 DSKYIISGSDDGNVRLWRS 377 Score = 43.5 bits (101), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 69/285 (24%), Positives = 103/285 (36%), Gaps = 89/285 (31%) Query: 10 TLKGHNGWVTQI-ATTPQF----PDM-----ILSASRDKTIIMWKLTRDE---------- 49 + K H G VT + T P+F PD+ +LS S DKT+ +W + D+ Sbjct: 105 SFKAHYGLVTGLCVTQPRFHDKKPDLKSQNFMLSCSDDKTVKLWSINVDDYSNKNSSDND 164 Query: 50 --TNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTT------------G 95 TN R G S F + FA G+ + LWD+ Sbjct: 165 SVTNEEGLIRTFDGESAFQGIDSHRENSTFATGGA---KIHLWDVNRLKPVSDLSWGADN 221 Query: 96 TTTRRFVGHTKDVLSVAFSSDN-------------RQIVSGSRDKTIKLWNTLGVCKYTV 142 T+ +F + D+L+ + SDN ++IV R I WN + + Sbjct: 222 ITSLKFNQNETDILA-STGSDNSIVLYDLRTNSPTQKIVQTMRTNAI-CWNPMEAFNFVT 279 Query: 143 QDESHSEWVSCVR--------------------FSPNSSNPIIVSCGWDKLVKVWNLANC 182 +E H+ + +R FSP IV+ +DK ++++ Sbjct: 280 ANEDHNAYYYDMRNLSRSLNVFKDHVSAVMDVDFSPTGDE--IVTGSYDKSIRIY----- 332 Query: 183 KLKTNH-----IGHTGYLN---TVTVSPDGSLCASGGKDGQAMLW 219 KTNH I HT + V S D SG DG LW Sbjct: 333 --KTNHGHSREIYHTKRMQHVFQVKYSMDSKYIISGSDDGNVRLW 375 Score = 42.7 bits (99), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 55/189 (29%), Positives = 86/189 (45%), Gaps = 34/189 (17%) Query: 103 GHTKDVLSVA--FSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVS--CV---R 155 GH V ++A + S N+ + +GS D IK WN + + V ++H V+ CV R Sbjct: 65 GHRDGVYAIAKNYGSLNK-LATGSADGVIKYWN-MSTREEFVSFKAHYGLVTGLCVTQPR 122 Query: 156 F---SPN-SSNPIIVSCGWDKLVKVWNL-------ANCKLKTNHIGHTGYLNT------- 197 F P+ S ++SC DK VK+W++ N + G + T Sbjct: 123 FHDKKPDLKSQNFMLSCSDDKTVKLWSINVDDYSNKNSSDNDSVTNEEGLIRTFDGESAF 182 Query: 198 --VTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLD-GGDIINALCFSPNRYWLCAATGP 254 + + S A+GG + LWD+N K + L G D I +L F+ N + A+TG Sbjct: 183 QGIDSHRENSTFATGG--AKIHLWDVNRLKPVSDLSWGADNITSLKFNQNETDILASTGS 240 Query: 255 --SIKIWDL 261 SI ++DL Sbjct: 241 DNSIVLYDL 249 >3BG0-A nrPDB Length = 316 Score = 45.8 bits (107), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 55/198 (27%), Positives = 81/198 (40%), Gaps = 30/198 (15%) Query: 7 LRGTLKGHNGWVTQIA-TTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHF 65 L L+GH G V Q+A P + +++ S S D+ +I+W R+E GH Sbjct: 49 LIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIW---REENGTWEKSHEHAGHDSS 105 Query: 66 VSDVVISSD--GQFALSGSWDGTLRL--------WDL-------TTGTTTRRFV-----G 103 V+ V + G GS DG + L W++ T G + G Sbjct: 106 VNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPG 165 Query: 104 HTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTL--GVCKYTVQDESHSEWVSCVRFSPNSS 161 D S + ++ SG D IKLW G K + E+HS+WV V ++P+ Sbjct: 166 SLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIG 225 Query: 162 NP--IIVSCGWDKLVKVW 177 P I SC D V +W Sbjct: 226 LPTSTIASCSQDGRVFIW 243 Score = 31.6 bits (70), Expect = 0.45, Method: Compositional matrix adjust. Identities = 31/138 (22%), Positives = 63/138 (45%), Gaps = 17/138 (12%) Query: 119 QIVSGSRDKTIKLWNTLGVCKYTVQD-ESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVW 177 ++ + S D+++K+++ + + D H V V ++ I+ SC +D+ V +W Sbjct: 27 RLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIW 86 Query: 178 NLANCKLKTN--HIGHTGYLNTVTVSPD--GSLCASGGKDGQAML--------WDLNEGK 225 N + + H GH +N+V +P G + A G DG L W++ + Sbjct: 87 REENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKIN 146 Query: 226 HLYTLDGGDIINALCFSP 243 + +T+ NA+ ++P Sbjct: 147 NAHTIG----CNAVSWAP 160 >5WLC-SG nrPDB Length = 573 Score = 45.4 bits (106), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 39/148 (26%), Positives = 65/148 (43%), Gaps = 10/148 (6%) Query: 103 GHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNT--LGVCKYTVQDESHSEWVSCVRFSPNS 160 GH ++L+VA S D + +V+G RD+ + +W+T L K + E +S F N Sbjct: 234 GHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRRGEVLSLA-FRKN- 291 Query: 161 SNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWD 220 S+ + SC D ++ +++ GH + ++ G +D AMLW Sbjct: 292 SDQLYASCA-DFKIRTYSINQFSQLEILYGHHDIVEDISALAMERCVTVGARDRTAMLWK 350 Query: 221 LNEGKHLYTLDGGDIINALCFSPNRYWL 248 + + L T GGD L R W+ Sbjct: 351 IPDETRL-TFRGGDEPQKLL----RRWM 373 Score = 37.4 bits (85), Expect = 0.008, Method: Compositional matrix adjust. Identities = 50/266 (18%), Positives = 100/266 (37%), Gaps = 18/266 (6%) Query: 2 TEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRG 61 T + T +GH + +A +P +++ RD+ +I+W IP + RG Sbjct: 223 TSKHEYENTTEGHYDEILTVAASPD-GKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRRG 281 Query: 62 HSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIV 121 V + + + D +R + + + GH V ++ + R + Sbjct: 282 E---VLSLAFRKNSDQLYASCADFKIRTYSINQFSQLEILYGHHDIVEDISALAMERCVT 338 Query: 122 SGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLAN 181 G+RD+T LW + T + + + N+ G D VK + + Sbjct: 339 VGARDRTAMLWKIPDETRLTFRGGDEPQKLLRRWMKENAKE------GEDGEVKYPDESE 392 Query: 182 CKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCF 241 L G ++ V++ D +G +G LW L + K ++T I + + Sbjct: 393 APL----FFCEGSIDVVSMVDDFHFI-TGSDNGNICLWSLAKKKPIFT---ERIAHGILP 444 Query: 242 SPNRYWLCAATGPSIKIWDLEGKIIV 267 P+ + T ++ L+GK ++ Sbjct: 445 EPSFNDISGETDEELRKRQLQGKKLL 470 >5CXB-B nrPDB Length = 369 Score = 45.1 bits (105), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 23/71 (32%), Positives = 40/71 (56%), Gaps = 4/71 (5%) Query: 190 GHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYT--LDGGDIINALCFSPNR-- 245 GH G + +V + P G A+GG DG +W+L G+ +++ L+G + +N + + P + Sbjct: 19 GHEGRVRSVAIDPTGVALATGGDDGTVRVWELLTGRQVWSVKLNGDEAVNTVRWRPTKDT 78 Query: 246 YWLCAATGPSI 256 + L AA G I Sbjct: 79 FILAAAAGEDI 89 Score = 33.5 bits (75), Expect = 0.12, Method: Compositional matrix adjust. Identities = 17/42 (40%), Positives = 22/42 (52%) Query: 54 IPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTG 95 + Q RGH V V I G +G DGT+R+W+L TG Sbjct: 12 VQQTIFRGHEGRVRSVAIDPTGVALATGGDDGTVRVWELLTG 53 Score = 28.1 bits (61), Expect = 4.9, Method: Compositional matrix adjust. Identities = 18/73 (24%), Positives = 31/73 (42%) Query: 101 FVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNS 160 F GH V SVA + +G D T+++W L + + E V+ VR+ P Sbjct: 17 FRGHEGRVRSVAIDPTGVALATGGDDGTVRVWELLTGRQVWSVKLNGDEAVNTVRWRPTK 76 Query: 161 SNPIIVSCGWDKL 173 I+ + + + Sbjct: 77 DTFILAAAAGEDI 89 >5K0Y-T nrPDB Length = 329 Score = 45.1 bits (105), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 36/154 (23%), Positives = 68/154 (44%), Gaps = 18/154 (11%) Query: 75 GQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNT 134 G+ ++G G L + +G H++ + + S + V+ S+D T KL+++ Sbjct: 158 GECIIAGHESGELNQYSAKSGEVLVNVKEHSRQINDIQLSREMTMFVTASKDNTAKLFDS 217 Query: 135 LGV-CKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKL-------------VKVWNLA 180 + + T + E E + SPN + ++V G + + + ++LA Sbjct: 218 TTLEHQKTFRTEPPRELAA---LSPNYEH-VVVGGGQEAMDVTTTSTRIGKFEARFFHLA 273 Query: 181 NCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDG 214 + GH G +N+V PDG +SGG+DG Sbjct: 274 FEEEFGRVKGHFGPINSVAFHPDGKSYSSGGEDG 307 Score = 41.6 bits (96), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 69/327 (21%), Positives = 119/327 (36%), Gaps = 49/327 (14%) Query: 11 LKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVV 70 L+GH +TQI + D++ + ++D + +W E GH+ V V Sbjct: 6 LQGHERSITQIKYNRE-GDLLFTVAKDPIVNVWYSVNGER-----LGTYMGHTGAVWCVD 59 Query: 71 ISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIK 130 D + L+GS D + RLWD TG + V + F I+ S DK + Sbjct: 60 ADWDTKHVLTGSADNSCRLWDCETGKQL-ALLKTNSAVRTCGFDFGG-NIIMFSTDK--Q 115 Query: 131 LWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVK-VWN-LANCKLKTNH 188 + V + ++D S + N+ + + C K+ VW L C + + Sbjct: 116 MGYQCFVSFFDLRDPSQID---------NNEPYMKIPCNDSKITSAVWGPLGECIIAGHE 166 Query: 189 IG------------------HTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTL 230 G H+ +N + +S + ++ + KD A L+D +H T Sbjct: 167 SGELNQYSAKSGEVLVNVKEHSRQINDIQLSREMTMFVTASKDNTAKLFDSTTLEHQKTF 226 Query: 231 DGGDIINALCFSPNRYWLCAATGP--------SIKIWDLEGKIIVDELKQEVISTSSKAE 282 SPN + G S +I E + ++E Sbjct: 227 RTEPPRELAALSPNYEHVVVGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFG 286 Query: 283 PPQCTSLAWSADGQTLFAGYTDNLVRV 309 P S+A+ DG++ +G D VR+ Sbjct: 287 P--INSVAFHPDGKSYSSGGEDGYVRI 311 Score = 36.6 bits (83), Expect = 0.013, Method: Compositional matrix adjust. Identities = 39/184 (21%), Positives = 69/184 (37%), Gaps = 25/184 (13%) Query: 145 ESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDG 204 + H ++ +++ N ++ + D +V VW N + ++GHTG + V D Sbjct: 7 QGHERSITQIKY--NREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDT 64 Query: 205 SLCASGGKDGQAMLWDLNEGKHLYTLDGGDII---------NALCFSPNRY--WLCAATG 253 +G D LWD GK L L + N + FS ++ + C Sbjct: 65 KHVLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGFDFGGNIIMFSTDKQMGYQCF--- 121 Query: 254 PSIKIWDLEGKIIVD--ELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQ 311 + +DL +D E ++ SK TS W G+ + AG+ + + Sbjct: 122 --VSFFDLRDPSQIDNNEPYMKIPCNDSK-----ITSAVWGPLGECIIAGHESGELNQYS 174 Query: 312 VTIG 315 G Sbjct: 175 AKSG 178 >4BZK-B nrPDB Length = 297 Score = 44.3 bits (103), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 65/254 (25%), Positives = 104/254 (40%), Gaps = 37/254 (14%) Query: 3 EQMTLRGTLKGHNGWVTQIA-TTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRG 61 E L TL GH G V ++ P+F ++ S S D +++WK E N Q A+ Sbjct: 41 ETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWK----EENGRWSQIAVHA 96 Query: 62 -HSHFVSDVVISSD--GQFALSGSWDGTLRLWDLTTGTTTRRFV--GHTKDVLSVAFS-- 114 HS V+ V + G L S DG + + + TT + H V S +++ Sbjct: 97 VHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPA 156 Query: 115 -----------SDNRQIVSGSRDKTIKLWNTLGVCKYTVQD---ESHSEWVSCVRFSPNS 160 ++R+ V+G D +K+W + V + E HS+WV V +SP Sbjct: 157 TIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTV 216 Query: 161 -SNPIIVSCGWDKLVKVWNLANCK-------LKTNHIGHTGYLNTVTVSPDGSLCASGGK 212 + S D+ +W N + LK + + ++S G++ A G Sbjct: 217 LLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLS--GNVLALSGG 274 Query: 213 DGQAMLWDLN-EGK 225 D + LW N EGK Sbjct: 275 DNKVTLWKENLEGK 288 Score = 28.5 bits (62), Expect = 3.5, Method: Compositional matrix adjust. Identities = 59/283 (20%), Positives = 100/283 (35%), Gaps = 39/283 (13%) Query: 61 GHSHFVSDVVISSDGQFALSGSWDGTLRLWDLT--TGTTTRRFVGHTKDVLSV--AFSSD 116 H+ + D V+ G+ + S D T++++++ T GH V V A Sbjct: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKF 66 Query: 117 NRQIVSGSRDKTIKLWNTL-GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVK 175 + S S D + +W G HS V+ V+++P+ P+++ D V Sbjct: 67 GTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVS 126 Query: 176 VWNLANCKLKTNHI--GHTGYLNTVTVSP-----DGS--------LCASGGKDGQAMLWD 220 V + I H +N+ + +P DG +GG D +W Sbjct: 127 VVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWK 186 Query: 221 LNEGKHLYTLDG-----GDIINALCFSP----NRYWLCAATGPSIKIW---DLEGKIIVD 268 N Y L+ D + + +SP Y + + IW + +G Sbjct: 187 YNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKT 246 Query: 269 ELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQ 311 LK+E P +WS G L DN V +W+ Sbjct: 247 LLKEEKF-------PDVLWRASWSLSGNVLALSGGDNKVTLWK 282 >4XYI-A nrPDB Length = 430 Score = 44.3 bits (103), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 52/214 (24%), Positives = 98/214 (45%), Gaps = 26/214 (12%) Query: 31 ILSASRDKTIIMW-----KLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFAL-SGSWD 84 + + + D +I +W L+ +++ P H+ V+D+ + L S S D Sbjct: 198 LATGTEDTSICVWDIKGKSLSLEKSIDVAPVSVYHRHTAVVNDLQFHLQHEALLTSVSDD 257 Query: 85 GTLRLWD--LTTGTTTRRFV-GHTKDVLSVAFSSDNRQIVS-GSRDKTIKLWNTLGVCKY 140 TL++ D L + ++ + V H + V VAF+ N +++ S D T+ LW+ + + Sbjct: 258 CTLQIHDTRLPSSSSASQCVKAHEQPVNGVAFNPFNDYLLATASADHTVALWDLRRLNQR 317 Query: 141 TVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANC--------------KLKT 186 E H + V V++SP+ PI+V+ D+ V VW+L+ +L Sbjct: 318 LHTLEGHEDEVYNVQWSPHDE-PILVTSSTDRRVCVWDLSKIGEEQTVEDSEDGAPELMF 376 Query: 187 NHIGHTGYLNTVTVSPDGS-LCASGGKDGQAMLW 219 H GHT ++ ++ +P+ + AS D +W Sbjct: 377 MHGGHTNRVSDLSWNPNNKWVLASLADDNILQIW 410 Score = 35.0 bits (79), Expect = 0.047, Method: Compositional matrix adjust. Identities = 38/141 (26%), Positives = 65/141 (46%), Gaps = 26/141 (18%) Query: 11 LKGHNGWVTQIATTPQFPDMILS-ASRDKTIIMWKLTRDETNYGIPQR--ALRGHSHFVS 67 +K H V +A P F D +L+ AS D T+ +W L R + QR L GH V Sbjct: 277 VKAHEQPVNGVAFNP-FNDYLLATASADHTVALWDLRR------LNQRLHTLEGHEDEVY 329 Query: 68 DVVISS-DGQFALSGSWDGTLRLWDLTT------------GTTTRRFV--GHTKDVLSVA 112 +V S D ++ S D + +WDL+ G F+ GHT V ++ Sbjct: 330 NVQWSPHDEPILVTSSTDRRVCVWDLSKIGEEQTVEDSEDGAPELMFMHGGHTNRVSDLS 389 Query: 113 FSSDNRQIVSG-SRDKTIKLW 132 ++ +N+ +++ + D +++W Sbjct: 390 WNPNNKWVLASLADDNILQIW 410 Score = 33.1 bits (74), Expect = 0.16, Method: Compositional matrix adjust. Identities = 21/91 (23%), Positives = 49/91 (53%), Gaps = 10/91 (10%) Query: 10 TLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTR-------DETNYGIPQRALR-- 60 TL+GH V + +P +++++S D+ + +W L++ +++ G P+ Sbjct: 320 TLEGHEDEVYNVQWSPHDEPILVTSSTDRRVCVWDLSKIGEEQTVEDSEDGAPELMFMHG 379 Query: 61 GHSHFVSDVVISSDGQFALSG-SWDGTLRLW 90 GH++ VSD+ + + ++ L+ + D L++W Sbjct: 380 GHTNRVSDLSWNPNNKWVLASLADDNILQIW 410 >6E29-D nrPDB Length = 345 Score = 44.3 bits (103), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 25/73 (34%), Positives = 41/73 (56%), Gaps = 3/73 (4%) Query: 61 GHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQI 120 GHS + V + G F SG DGT+ +WDL T R+ GH+K++ S+++S R + Sbjct: 26 GHS---TCVRFNRKGDFLASGRVDGTVVIWDLETMGVARKLRGHSKNITSLSWSRCGRYL 82 Query: 121 VSGSRDKTIKLWN 133 +S + + LW+ Sbjct: 83 LSACQGWKVILWD 95 Score = 33.9 bits (76), Expect = 0.091, Method: Compositional matrix adjust. Identities = 21/74 (28%), Positives = 35/74 (47%), Gaps = 2/74 (2%) Query: 152 SCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGG 211 +CVRF N + S D V +W+L + GH+ + +++ S G S Sbjct: 29 TCVRF--NRKGDFLASGRVDGTVVIWDLETMGVARKLRGHSKNITSLSWSRCGRYLLSAC 86 Query: 212 KDGQAMLWDLNEGK 225 + + +LWDL +GK Sbjct: 87 QGWKVILWDLQDGK 100 Score = 33.5 bits (75), Expect = 0.12, Method: Compositional matrix adjust. Identities = 23/71 (32%), Positives = 34/71 (47%), Gaps = 5/71 (7%) Query: 29 DMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLR 88 D + S D T+++W L G+ R LRGHS ++ + S G++ LS + Sbjct: 38 DFLASGRVDGTVVIWDLE----TMGVA-RKLRGHSKNITSLSWSRCGRYLLSACQGWKVI 92 Query: 89 LWDLTTGTTTR 99 LWDL G R Sbjct: 93 LWDLQDGKRYR 103 Score = 32.3 bits (72), Expect = 0.30, Method: Compositional matrix adjust. Identities = 24/73 (32%), Positives = 34/73 (46%), Gaps = 2/73 (2%) Query: 192 TGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG-GDIINALCFSP-NRYWLC 249 +G+ V + G ASG DG ++WDL L G I +L +S RY L Sbjct: 25 SGHSTCVRFNRKGDFLASGRVDGTVVIWDLETMGVARKLRGHSKNITSLSWSRCGRYLLS 84 Query: 250 AATGPSIKIWDLE 262 A G + +WDL+ Sbjct: 85 ACQGWKVILWDLQ 97 >3JRP-A nrPDB Length = 379 Score = 43.9 bits (102), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 65/254 (25%), Positives = 103/254 (40%), Gaps = 37/254 (14%) Query: 3 EQMTLRGTLKGHNGWVTQIA-TTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRG 61 E L TL GH G V ++ P+F ++ S S D +++WK E N Q A+ Sbjct: 43 ETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWK----EENGRWSQIAVHA 98 Query: 62 -HSHFVSDV--VISSDGQFALSGSWDGTLRLWDLTTGTTTRRFV--GHTKDVLSVAFS-- 114 HS V+ V G L S DG + + + TT + H V S +++ Sbjct: 99 VHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPA 158 Query: 115 -----------SDNRQIVSGSRDKTIKLWNTLGVCKYTVQD---ESHSEWVSCVRFSPNS 160 ++R+ V+G D +K+W + V + E HS+WV V +SP Sbjct: 159 TIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTV 218 Query: 161 -SNPIIVSCGWDKLVKVWNLANCK-------LKTNHIGHTGYLNTVTVSPDGSLCASGGK 212 + S D+ +W N + LK + + ++S G++ A G Sbjct: 219 LLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLS--GNVLALSGG 276 Query: 213 DGQAMLWDLN-EGK 225 D + LW N EGK Sbjct: 277 DNKVTLWKENLEGK 290 Score = 28.5 bits (62), Expect = 3.6, Method: Compositional matrix adjust. Identities = 59/283 (20%), Positives = 99/283 (34%), Gaps = 39/283 (13%) Query: 61 GHSHFVSDVVISSDGQFALSGSWDGTLRLWDLT--TGTTTRRFVGHTKDVLSV--AFSSD 116 H+ + D V+ G+ + S D T++++++ T GH V V A Sbjct: 9 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKF 68 Query: 117 NRQIVSGSRDKTIKLWNTL-GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVK 175 + S S D + +W G HS V+ V+++P+ P+++ D V Sbjct: 69 GTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVS 128 Query: 176 VWNLANCKLKTNHI--GHTGYLNTV-----TVSPDGS--------LCASGGKDGQAMLWD 220 V + I H +N+ T+ DG +GG D +W Sbjct: 129 VVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWK 188 Query: 221 LNEGKHLYTLDG-----GDIINALCFSP----NRYWLCAATGPSIKIW---DLEGKIIVD 268 N Y L+ D + + +SP Y + + IW + +G Sbjct: 189 YNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKT 248 Query: 269 ELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQ 311 LK+E P +WS G L DN V +W+ Sbjct: 249 LLKEEKF-------PDVLWRASWSLSGNVLALSGGDNKVTLWK 284 >4G56-B nrPDB Length = 357 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 30/105 (28%), Positives = 51/105 (48%), Gaps = 2/105 (1%) Query: 31 ILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLW 90 IL AS + +W++ E+ + + A H V + + SDG A+SG D ++++W Sbjct: 108 ILVASDSGAVELWEILEKESLL-VNKFAKYEHDDIVKTLSVFSDGTQAVSGGKDFSVKVW 166 Query: 91 DLTTGTTTRRFVGHTKDVLSVAFSSDNRQI-VSGSRDKTIKLWNT 134 DL+ + + H+ +V VA I +S D I LW+T Sbjct: 167 DLSQKAVLKSYNAHSSEVNCVAACPGKDTIFLSCGEDGRILLWDT 211 >2AQ5-A nrPDB Length = 402 Score = 42.7 bits (99), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 36/126 (28%), Positives = 55/126 (43%), Gaps = 9/126 (7%) Query: 13 GHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQR----ALRGHSHFVSD 68 GH V IA P ++I S S D T+++W++ + +P R L GH+ V Sbjct: 79 GHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIP--DGGLVLPLREPVITLEGHTKRVGI 136 Query: 69 VVISSDGQ-FALSGSWDGTLRLWDLTTGTTTRRFVG--HTKDVLSVAFSSDNRQIVSGSR 125 V Q LS D + +WD+ TG H + SV +S D I + R Sbjct: 137 VAWHPTAQNVLLSAGCDNVILVWDVGTGAAVLTLGPDVHPDTIYSVDWSRDGALICTSCR 196 Query: 126 DKTIKL 131 DK +++ Sbjct: 197 DKRVRV 202 Score = 33.1 bits (74), Expect = 0.17, Method: Compositional matrix adjust. Identities = 43/167 (25%), Positives = 76/167 (45%), Gaps = 13/167 (7%) Query: 10 TLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDV 69 TL+GH V +A P +++LSA D I++W + T + H + V Sbjct: 126 TLEGHTKRVGIVAWHPTAQNVLLSAGCDNVILVWDVG---TGAAVLTLGPDVHPDTIYSV 182 Query: 70 VISSDGQFALSGSWDGTLRLWDLTTGTTTR---RFVGHTKDVLSVAFSSDNRQIVSG-SR 125 S DG + D +R+ + GT R T+ V +V F S+ + + +G SR Sbjct: 183 DWSRDGALICTSCRDKRVRVIEPRKGTVVAEKDRPHEGTRPVHAV-FVSEGKILTTGFSR 241 Query: 126 --DKTIKLWNTLGVCK-YTVQDESHSEWVSCVRFSPNSSNPIIVSCG 169 ++ + LW+T + + ++Q+ S V F P+++ I+ CG Sbjct: 242 MSERQVALWDTKHLEEPLSLQELDTSSGVLLPFFDPDTN--IVYLCG 286 Score = 29.3 bits (64), Expect = 2.2, Method: Compositional matrix adjust. Identities = 35/138 (25%), Positives = 57/138 (41%), Gaps = 18/138 (13%) Query: 190 GHTGYLNTVTVSP-DGSLCASGGKDGQAMLWDLNEG-------KHLYTLDGG-DIINALC 240 GHT + + P + ++ ASG +D M+W++ +G + + TL+G + + Sbjct: 79 GHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKRVGIVA 138 Query: 241 FSP--NRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTL 298 + P L A I +WD+ V L +V P S+ WS DG + Sbjct: 139 WHPTAQNVLLSAGCDNVILVWDVGTGAAVLTLGPDV-------HPDTIYSVDWSRDGALI 191 Query: 299 FAGYTDNLVRVWQVTIGT 316 D VRV + GT Sbjct: 192 CTSCRDKRVRVIEPRKGT 209 >3JB9-S nrPDB Length = 488 Score = 42.7 bits (99), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 34/121 (28%), Positives = 56/121 (46%), Gaps = 7/121 (5%) Query: 183 KLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTL-DGGDIINALCF 241 K + +I ++ ++ V PDG+L +G ++G+ ++ + G L + L F Sbjct: 324 KSQVYNITVAQHITSLAVHPDGNLFVAGLENGELRFFETSSGNELTKFGPHSSPVKTLQF 383 Query: 242 SPNRYWLCAATG--PSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTS-LAWSADGQTL 298 N YWL T I IWDL +V ++ + T A TS L S+DG+TL Sbjct: 384 GENGYWLVVTTNDDSDIFIWDLRKSELVQKIP---LQTKVAAVSLDITSQLLVSSDGETL 440 Query: 299 F 299 + Sbjct: 441 Y 441 >3JRO-A nrPDB Length = 753 Score = 42.7 bits (99), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 65/254 (25%), Positives = 103/254 (40%), Gaps = 37/254 (14%) Query: 3 EQMTLRGTLKGHNGWVTQIA-TTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRG 61 E L TL GH G V ++ P+F ++ S S D +++WK E N Q A+ Sbjct: 41 ETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWK----EENGRWSQIAVHA 96 Query: 62 -HSHFVSDV--VISSDGQFALSGSWDGTLRLWDLTTGTTTRRFV--GHTKDVLSVAFS-- 114 HS V+ V G L S DG + + + TT + H V S +++ Sbjct: 97 VHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPA 156 Query: 115 -----------SDNRQIVSGSRDKTIKLWNTLGVCKYTVQD---ESHSEWVSCVRFSPNS 160 ++R+ V+G D +K+W + V + E HS+WV V +SP Sbjct: 157 TIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTV 216 Query: 161 -SNPIIVSCGWDKLVKVWNLANCK-------LKTNHIGHTGYLNTVTVSPDGSLCASGGK 212 + S D+ +W N + LK + + ++S G++ A G Sbjct: 217 LLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLS--GNVLALSGG 274 Query: 213 DGQAMLWDLN-EGK 225 D + LW N EGK Sbjct: 275 DNKVTLWKENLEGK 288 >3JZG-A nrPDB Length = 402 Score = 40.0 bits (92), Expect = 0.001, Method: Compositional matrix adjust. Identities = 33/147 (22%), Positives = 63/147 (42%), Gaps = 25/147 (17%) Query: 13 GHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVIS 72 GH + ++ P+ P+++LS S+D + +W + D A+ G D V+S Sbjct: 149 GHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTL------VAIFGGVEGHRDEVLS 202 Query: 73 SD----GQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKT 128 +D G+ +S D +L+LW + ++R + K+ + NR +S Sbjct: 203 ADYDLLGEKIMSCGMDHSLKLWRI----NSKRMMNAIKESYDYNPNKTNRPFIS------ 252 Query: 129 IKLWNTLGVCKYTVQDESHSEWVSCVR 155 + ++ +D H +V CVR Sbjct: 253 ----QKIHFPDFSTRD-IHRNYVDCVR 274 Score = 36.2 bits (82), Expect = 0.019, Method: Compositional matrix adjust. Identities = 29/152 (19%), Positives = 65/152 (42%), Gaps = 8/152 (5%) Query: 140 YTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVT 199 Y D + + + N+S+P++ G ++++ N + +++GH +N + Sbjct: 99 YVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELK 158 Query: 200 VSP-DGSLCASGGKDGQAMLWDLNEGKHLYTLDGG------DIINALCFSPNRYWLCAAT 252 P D +L S KD LW++ + L + GG ++++A + Sbjct: 159 FHPRDPNLLLSVSKDHALRLWNI-QTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGM 217 Query: 253 GPSIKIWDLEGKIIVDELKQEVISTSSKAEPP 284 S+K+W + K +++ +K+ +K P Sbjct: 218 DHSLKLWRINSKRMMNAIKESYDYNPNKTNRP 249 >2PM9-A nrPDB Length = 416 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 28/102 (27%), Positives = 50/102 (49%), Gaps = 7/102 (6%) Query: 84 DGTLRLWDLTTGTTTRRFV--GHTKDVLSVAF-SSDNRQIVSGSRDKTIKLWNTLGVCKY 140 D ++ +WDL T + + GH K +LS+ + D ++S RD T+ LWN + Sbjct: 239 DPSILIWDLRNANTPLQTLNQGHQKGILSLDWCHQDEHLLLSSGRDNTVLLWNPESAEQL 298 Query: 141 TVQDESHSEWVSCVRFSPNSSNPIIVSCG-WDKLVKVWNLAN 181 + Q + W +F+P + P + +C +D ++V L N Sbjct: 299 S-QFPARGNWCFKTKFAPEA--PDLFACASFDNKIEVQTLQN 337 Score = 35.0 bits (79), Expect = 0.043, Method: Compositional matrix adjust. Identities = 58/261 (22%), Positives = 103/261 (39%), Gaps = 26/261 (9%) Query: 48 DETNYGIPQRA-LRGHSHFVSDVVISSDGQFAL-SGSWDGTLRLWDLT---------TGT 96 +E N I A HS V V ++ L SG +G + +WD+ T Sbjct: 97 NEANNAINSMARFSNHSSSVKTVKFNAKQDNVLASGGNNGEIFIWDMNKCTESPSNYTPL 156 Query: 97 TTRRFVGHTKDVLSVAFSSDNRQI-VSGSRDKTIKLWNTLGV-----CKYTVQDESHSEW 150 T + + +V+S+A++ + S +W+ YT + + Sbjct: 157 TPGQSMSSVDEVISLAWNQSLAHVFASAGSSNFASIWDLKAKKEVIHLSYTSPNSGIKQQ 216 Query: 151 VSCVRFSPNSSNPIIVSCGWDK--LVKVWNL--ANCKLKTNHIGHT-GYLNTVTVSPDGS 205 +S V + P +S + + G D + +W+L AN L+T + GH G L+ D Sbjct: 217 LSVVEWHPKNSTRVATATGSDNDPSILIWDLRNANTPLQTLNQGHQKGILSLDWCHQDEH 276 Query: 206 LCASGGKDGQAMLWDLNEGKHLYTLDG-GDIINALCFSPNR--YWLCAATGPSIKIWDLE 262 L S G+D +LW+ + L G+ F+P + CA+ I++ L+ Sbjct: 277 LLLSSGRDNTVLLWNPESAEQLSQFPARGNWCFKTKFAPEAPDLFACASFDNKIEVQTLQ 336 Query: 263 GKI-IVDELKQEVISTSSKAE 282 +DE + E S+ + Sbjct: 337 NLTNTLDEQETETKQQESETD 357 >5WLC-LN nrPDB Length = 776 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 32/142 (22%), Positives = 56/142 (39%), Gaps = 17/142 (11%) Query: 29 DMILSASRDKTIIMWKLTRDETNYG-----IPQRALRGHSHFVSDVVISSDGQFALSGSW 83 D ++ D I +W +++ N G + + S V V+ SG Sbjct: 199 DFVIGGCSDGRIRIWSAQKNDENMGRLLHTMKVDKAKKESTLVWSVIYLPRTDQIASGDS 258 Query: 84 DGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQ 143 G+++ WD T + F H DVL + +DN + S D+ I + T + Sbjct: 259 TGSIKFWDFQFATLNQSFKAHDADVLCLTTDTDNNYVFSAGVDRKI-----FQFSQNTNK 313 Query: 144 DESHSEWVSCVRFSPNSSNPII 165 + ++ WV NSSN ++ Sbjct: 314 SQKNNRWV-------NSSNRLL 328 >5LTD-A nrPDB Length = 525 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 21/81 (25%), Positives = 42/81 (51%), Gaps = 3/81 (3%) Query: 55 PQRALRGHSHFVSDVVISSDGQFALSGSWDGTL-RLWDLTTGTTTRRFV--GHTKDVLSV 111 P + H ++ + +S DG + S GT+ R++ + TG +F + + S+ Sbjct: 214 PTSVIEAHRTSLAAIALSKDGLLLATASDKGTIIRVFSVATGIKLYQFRRGTYPTKIYSL 273 Query: 112 AFSSDNRQIVSGSRDKTIKLW 132 AFS DNR +++ S +T+ ++ Sbjct: 274 AFSPDNRFVIASSATETVHIF 294 >5OV3-A nrPDB Length = 381 Score = 38.1 bits (87), Expect = 0.005, Method: Compositional matrix adjust. Identities = 25/93 (26%), Positives = 40/93 (43%), Gaps = 4/93 (4%) Query: 75 GQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNT 134 G G DG + +WD T + H V S+ +S D ++VS S D + W+ Sbjct: 37 GTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDV 96 Query: 135 L-GVCKYTVQDESHSEWVSCVRFSPNSSNPIIV 166 L G C + S + V++ P N ++V Sbjct: 97 LSGDCDQRFRFPSP---ILKVQYHPRDQNKVLV 126 Score = 33.9 bits (76), Expect = 0.100, Method: Compositional matrix adjust. Identities = 21/55 (38%), Positives = 29/55 (52%), Gaps = 2/55 (3%) Query: 262 EGKIIV-DELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIG 315 +G+I++ D L + + S P C SL WS DG L + TDN+V W V G Sbjct: 46 DGRIVIWDFLTRGIAKIISAHIHPVC-SLCWSRDGHKLVSASTDNIVSQWDVLSG 99 Score = 31.6 bits (70), Expect = 0.53, Method: Compositional matrix adjust. Identities = 30/107 (28%), Positives = 47/107 (43%), Gaps = 8/107 (7%) Query: 37 DKTIIMWK-LTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTG 95 D I++W LTR GI + + H H V + S DG +S S D + WD+ +G Sbjct: 46 DGRIVIWDFLTR-----GI-AKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSG 99 Query: 96 TTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTV 142 +RF +L V + ++ V K+ + TL K+ V Sbjct: 100 DCDQRF-RFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVV 145 >3W15-A nrPDB Length = 368 Score = 37.0 bits (84), Expect = 0.012, Method: Compositional matrix adjust. Identities = 51/201 (25%), Positives = 91/201 (45%), Gaps = 41/201 (20%) Query: 84 DGTLRLWDLTTGT-TTRRFVGHTKDVLSVAFSSDNRQ-IVSGSRDKTIKLWNTL------ 135 DGTLRL+D T F H ++V S ++ NRQ +S S D +IK+W+ L Sbjct: 84 DGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLM 143 Query: 136 --------------GVCKYTVQDESH---SEWVSCV---RFSPNSSNPIIVSCGWDKLVK 175 + ++ +S S+ +CV +FSP+ N +++SC + Sbjct: 144 TLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQN-LVLSCSGNSYAS 202 Query: 176 VWN--LANCKLKTNHIGHTGYLNTVTVSPDG---SLCASGGKDGQAMLWDLNEGKHLYTL 230 +++ L + K + N + H+G L +T + + A+GG D +WD+ + Sbjct: 203 LFDIRLPSGKNQNNFLVHSG-LEALTCDFNKYRPYVVATGGVDNAIRIWDI----RMLNK 257 Query: 231 DGGDIINALCFS--PNRYWLC 249 + G + N+ C + PN + L Sbjct: 258 NPGQLHNSSCINEIPNAHGLA 278 Score = 28.5 bits (62), Expect = 3.8, Method: Compositional matrix adjust. Identities = 25/95 (26%), Positives = 43/95 (45%), Gaps = 19/95 (20%) Query: 13 GHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQR-------ALRG---- 61 H + ++ +P ++++SAS D T +W RD +N G + A +G Sbjct: 274 AHGLAIRKVTWSPHHSNILMSASYDMTCRIW---RDLSNDGAKETYKTNSTDATKGSIFN 330 Query: 62 ---HSHFV--SDVVISSDGQFALSGSWDGTLRLWD 91 HS FV +D + + S +WDG L +W+ Sbjct: 331 FTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 365 >5CXC-A nrPDB Length = 510 Score = 36.2 bits (82), Expect = 0.021, Method: Compositional matrix adjust. Identities = 24/115 (20%), Positives = 46/115 (40%), Gaps = 7/115 (6%) Query: 117 NRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKV 176 +++S S D +++WN G T SH + ++ + ++ + S G D+ V+V Sbjct: 158 QERVLSASYDGLLRIWNASGSVIATSPSGSHGGHTASIKAAKFLTSDRLASAGMDRTVRV 217 Query: 177 WNLANCKLKTNHI-------GHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEG 224 W T + GHTG ++ + V + DG W ++ Sbjct: 218 WKYTESDHFTGELKPTLELYGHTGSVDWLDVDGHSKHILTASADGAIGFWSASKA 272 Score = 34.3 bits (77), Expect = 0.075, Method: Compositional matrix adjust. Identities = 17/35 (48%), Positives = 25/35 (71%), Gaps = 1/35 (2%) Query: 59 LRGHSHFVSDVVISSDGQFAL-SGSWDGTLRLWDL 92 LRGH++ V + S + +++L SGS DGT R+WDL Sbjct: 399 LRGHANKVVSLSPSPENEYSLVSGSHDGTCRVWDL 433 Score = 34.3 bits (77), Expect = 0.082, Method: Compositional matrix adjust. Identities = 21/70 (30%), Positives = 36/70 (51%), Gaps = 11/70 (15%) Query: 79 LSGSWDGTLRLWD----LTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNT 134 LS S+DG LR+W+ + + + GHT + + F + +R + S D+T+++W Sbjct: 162 LSASYDGLLRIWNASGSVIATSPSGSHGGHTASIKAAKFLTSDR-LASAGMDRTVRVW-- 218 Query: 135 LGVCKYTVQD 144 KYT D Sbjct: 219 ----KYTESD 224 Score = 29.3 bits (64), Expect = 2.4, Method: Compositional matrix adjust. Identities = 19/64 (29%), Positives = 30/64 (46%), Gaps = 2/64 (3%) Query: 29 DMILSASRDKTIIMWKLTRDETNYG--IPQRALRGHSHFVSDVVISSDGQFALSGSWDGT 86 D + SA D+T+ +WK T + G P L GH+ V + + + L+ S DG Sbjct: 204 DRLASAGMDRTVRVWKYTESDHFTGELKPTLELYGHTGSVDWLDVDGHSKHILTASADGA 263 Query: 87 LRLW 90 + W Sbjct: 264 IGFW 267 Score = 27.3 bits (59), Expect = 9.1, Method: Compositional matrix adjust. Identities = 36/152 (23%), Positives = 59/152 (38%), Gaps = 6/152 (3%) Query: 74 DGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVA----FSSDNRQIVSGSRDKTI 129 D A S S D T+R DLTTG T +LS++ + + + +G+ + I Sbjct: 324 DRTVAYSASQDHTVRTLDLTTGQVVSTLT-LTHPLLSLSALTRAGTTSPLLAAGTSARHI 382 Query: 130 KLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPI-IVSCGWDKLVKVWNLANCKLKTNH 188 + + T V SP+ N +VS D +VW+L + + T Sbjct: 383 TMVDPRASSATTSVMTLRGHANKVVSLSPSPENEYSLVSGSHDGTCRVWDLRSVRPATKE 442 Query: 189 IGHTGYLNTVTVSPDGSLCASGGKDGQAMLWD 220 G G ++ + AS GK + + D Sbjct: 443 EGSLGGVSEPVYVIERESWASKGKKKRPVAGD 474 >5TF2-A nrPDB Length = 407 Score = 36.2 bits (82), Expect = 0.022, Method: Compositional matrix adjust. Identities = 23/92 (25%), Positives = 44/92 (47%), Gaps = 5/92 (5%) Query: 159 NSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAML 218 N N ++ + G D V+VW + + + H G + + + PDG L + G+D +A + Sbjct: 181 NHDNTLLATGGTDGYVRVWKVPSLEKVLEFKAHEGEIEDLALGPDGKL-VTVGRDLKASV 239 Query: 219 WDLNE-GKHLYTLDGGDIINALCFSPNRYWLC 249 W ++ L+ + G ++ +P RY C Sbjct: 240 WQKDQLVTQLHWQENGPTFSS---TPYRYQAC 268 >5N4A-A nrPDB Length = 771 Score = 35.8 bits (81), Expect = 0.026, Method: Compositional matrix adjust. Identities = 46/199 (23%), Positives = 82/199 (41%), Gaps = 19/199 (9%) Query: 119 QIVSGSRDKTIKLWNTLGVCKYTVQD------ESHSEWVSCVRFSPNSSNPIIVSCGWDK 172 ++ + S D+TI WN LG + V + H VS + ++ V+C D Sbjct: 27 ELFTCSDDQTIHKWNMLGEPEQKVSTLDAYFTDMHWYPVSSKKTQAGGTDVFAVACT-DG 85 Query: 173 LVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG 232 VK+ + +++ + GH G ++ S DG+ A+ G+DG +W N G TL Sbjct: 86 SVKILSRTG-RVEKSIEGHKGACISLRWSYDGTALATAGEDGSVKIWSRN-GMLRSTLAQ 143 Query: 233 GD-IINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAW 291 D + ++ ++ + LC TG + +++ L + KA + W Sbjct: 144 ADSPVYSIVWAYDCDQLCYCTGSN---------VVIKSLSSNAKQNAWKAHDGVVLKVDW 194 Query: 292 SADGQTLFAGYTDNLVRVW 310 S + G D +VW Sbjct: 195 SPINHLIITGGEDCKYKVW 213 Score = 34.7 bits (78), Expect = 0.063, Method: Compositional matrix adjust. Identities = 44/206 (21%), Positives = 83/206 (40%), Gaps = 35/206 (16%) Query: 31 ILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDV----VISSDGQ------FALS 80 + + S D+TI W + G P++ + + +D+ V S Q FA++ Sbjct: 28 LFTCSDDQTIHKWNM------LGEPEQKVSTLDAYFTDMHWYPVSSKKTQAGGTDVFAVA 81 Query: 81 GSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKY 140 + DG++++ TG + GH +S+ +S D + + D ++K+W+ G+ + Sbjct: 82 CT-DGSVKILS-RTGRVEKSIEGHKGACISLRWSYDGTALATAGEDGSVKIWSRNGMLRS 139 Query: 141 TVQDESHSEW-----VSCVRFSP-NSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGY 194 T+ + C + SN +I S + W H G Sbjct: 140 TLAQADSPVYSIVWAYDCDQLCYCTGSNVVIKSLSSNAKQNAWK-----------AHDGV 188 Query: 195 LNTVTVSPDGSLCASGGKDGQAMLWD 220 + V SP L +GG+D + +WD Sbjct: 189 VLKVDWSPINHLIITGGEDCKYKVWD 214 >4XFV-A nrPDB Length = 792 Score = 35.8 bits (81), Expect = 0.028, Method: Compositional matrix adjust. Identities = 44/194 (22%), Positives = 79/194 (40%), Gaps = 34/194 (17%) Query: 9 GTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSD 68 TLKGH VT + P D ++SAS D + +WK T+Y Q ++ H+ Sbjct: 57 ATLKGHEAEVTCVRFVPD-SDFMVSASEDHHVKIWKF----TDYSHLQ-CIQTIQHYSKT 110 Query: 69 VV-ISSDGQFALSGSWDGTLRLWDLTTG----------TTTRRF----------VGHTKD 107 +V +S+ G DGT+ +W T + F V K Sbjct: 111 IVALSALPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKY 170 Query: 108 VLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSS--NPII 165 +L++ ++ N I S I + + C+ + E H +WV + F + + ++ Sbjct: 171 LLAIGGTNVNVFIAS-----FILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLL 225 Query: 166 VSCGWDKLVKVWNL 179 S D+ +++W + Sbjct: 226 CSGSQDRYIRLWRI 239 Score = 33.5 bits (75), Expect = 0.11, Method: Compositional matrix adjust. Identities = 48/219 (21%), Positives = 90/219 (41%), Gaps = 39/219 (17%) Query: 86 TLRLWDLTTGTTTRRFV---GHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTV 142 T+ LWD + GH +V V F D+ +VS S D +K+W K+T Sbjct: 41 TIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIW------KFT- 93 Query: 143 QDESHSEWVSCVRFSPN-----SSNPIIVSCG-WDKLVKVW--NLANCKLKTNH------ 188 D SH + + ++ S+ P ++S G D + +W N+ N + H Sbjct: 94 -DYSHLQCIQTIQHYSKTIVALSALPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKK 152 Query: 189 -IGHTGYLNTVTVSPDGSLCASGGKDGQAMLWD-------LNEGKHLYTLDG-GDIINAL 239 + L+ V L A GG + + + + + + L+G D + +L Sbjct: 153 GFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSL 212 Query: 240 CF----SPNRYWLCAATGPS-IKIWDLEGKIIVDELKQE 273 F +P Y LC+ + I++W + ++D+ +++ Sbjct: 213 AFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEED 251 Score = 33.5 bits (75), Expect = 0.13, Method: Compositional matrix adjust. Identities = 53/243 (21%), Positives = 97/243 (39%), Gaps = 30/243 (12%) Query: 1 MTEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALR 60 M E +T G N TQ++ + I++ KTI +W + N G+ L+ Sbjct: 5 MVECITPEAIFIGANK-QTQVSDIHKVKK-IVAFGAGKTIALWDPI-EPNNKGV-YATLK 60 Query: 61 GHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTR--RFVGHTKDVLSVAFSSDNR 118 GH V+ V D F +S S D +++W T + + + + H + VA S+ Sbjct: 61 GHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTI-VALSALPS 119 Query: 119 QIVSGSRDKTIKLW------NTLGVC-KYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWD 171 I G D TI +W + G+ ++T++ + C+ S +++ G Sbjct: 120 LISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFF--YPLCLSLSKVEEKKYLLAIGGT 177 Query: 172 KLVKVW---------NLANCKLKTNHIGHTGYLNTVTV----SPDGSLCASGGKDGQAML 218 V V+ + C++ GH ++ ++ +P L SG +D L Sbjct: 178 N-VNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRL 236 Query: 219 WDL 221 W + Sbjct: 237 WRI 239 Score = 33.1 bits (74), Expect = 0.17, Method: Compositional matrix adjust. Identities = 37/131 (28%), Positives = 60/131 (45%), Gaps = 11/131 (8%) Query: 11 LKGHNGWVTQIATTPQFPDMILSASRDKTI--IMWKLTRDETNYGIPQRALRGHSHFVSD 68 L GH +T + +P +I SA R + + ++ E N+ + AL HS ++ Sbjct: 558 LYGHGFEITCLDISPD-QKLIASACRSNNVQNAVIRIFSTE-NWLEIKPALPFHSLTITR 615 Query: 69 VVISSDGQFALSGSWDGTLRLWD--LTTGTTTRRFVG---HTKDVLSVAFS--SDNRQIV 121 + S DG+F LS D LW+ + T RF HT+ + ++ V Sbjct: 616 LKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFV 675 Query: 122 SGSRDKTIKLW 132 + SRDKT+K+W Sbjct: 676 TASRDKTVKVW 686 >6BX3-B nrPDB Length = 412 Score = 35.4 bits (80), Expect = 0.029, Method: Compositional matrix adjust. Identities = 19/63 (30%), Positives = 33/63 (52%), Gaps = 4/63 (6%) Query: 75 GQFALSGSWDGTLRLWDLTTGTTT----RRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIK 130 G + G +G L ++D+ T H + + S+A+S D R +++ SRD +IK Sbjct: 37 GDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIK 96 Query: 131 LWN 133 LW+ Sbjct: 97 LWD 99 Score = 30.4 bits (67), Expect = 1.0, Method: Compositional matrix adjust. Identities = 13/40 (32%), Positives = 23/40 (57%) Query: 54 IPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLT 93 +P L H ++ + S DG+ L+ S D +++LWDL+ Sbjct: 62 VPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLS 101 Score = 30.0 bits (66), Expect = 1.3, Method: Compositional matrix adjust. Identities = 35/142 (24%), Positives = 64/142 (45%), Gaps = 12/142 (8%) Query: 152 SCVRFSPNSSNPIIVSCGWDKLVKVWNLANCK---LKTNHIG-HTGYLNTVTVSPDGSLC 207 C++FSP + + + C LV ++++ + + N +G H + ++ SPDG L Sbjct: 29 ECLQFSP-CGDYLALGCANGALV-IYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLL 86 Query: 208 ASGGKDGQAMLWDLNE-GKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKII 266 + +D LWDL++ K L + I + + LC AT I++ + Sbjct: 87 LTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVAT-----IFEESDAYV 141 Query: 267 VDELKQEVISTSSKAEPPQCTS 288 +D V S SK++ Q +S Sbjct: 142 IDFSNDPVASLLSKSDEKQLSS 163 >6CB1-s nrPDB Length = 569 Score = 35.4 bits (80), Expect = 0.032, Method: Compositional matrix adjust. Identities = 14/43 (32%), Positives = 25/43 (58%) Query: 186 TNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLY 228 T + GH G + T+++ P G A+G DG +W++ G+ +Y Sbjct: 193 TIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVY 235 Score = 30.8 bits (68), Expect = 0.80, Method: Compositional matrix adjust. Identities = 15/40 (37%), Positives = 22/40 (55%) Query: 61 GHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRR 100 GH V + I G + +GS DGT+R+W++ TG R Sbjct: 197 GHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYR 236 Score = 30.4 bits (67), Expect = 1.0, Method: Compositional matrix adjust. Identities = 17/70 (24%), Positives = 39/70 (55%), Gaps = 5/70 (7%) Query: 101 FVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTL---GVCKYT-VQDESHSEW-VSCVR 155 + GH V +++ + +GS D T+++W L V + T + DE + ++ + C+ Sbjct: 195 YAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIECIE 254 Query: 156 FSPNSSNPII 165 ++P+++N I+ Sbjct: 255 WNPDANNGIL 264 >6C0F-s nrPDB Length = 807 Score = 35.0 bits (79), Expect = 0.040, Method: Compositional matrix adjust. Identities = 14/43 (32%), Positives = 25/43 (58%) Query: 186 TNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLY 228 T + GH G + T+++ P G A+G DG +W++ G+ +Y Sbjct: 431 TIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVY 473 Score = 30.4 bits (67), Expect = 0.93, Method: Compositional matrix adjust. Identities = 15/40 (37%), Positives = 22/40 (55%) Query: 61 GHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRR 100 GH V + I G + +GS DGT+R+W++ TG R Sbjct: 435 GHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYR 474 Score = 30.4 bits (67), Expect = 1.1, Method: Compositional matrix adjust. Identities = 17/71 (23%), Positives = 39/71 (54%), Gaps = 5/71 (7%) Query: 101 FVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTL---GVCKYT-VQDESHSEW-VSCVR 155 + GH V +++ + +GS D T+++W L V + T + DE + ++ + C+ Sbjct: 433 YAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIECIE 492 Query: 156 FSPNSSNPIIV 166 ++P+++N I+ Sbjct: 493 WNPDANNGILA 503 >1H78-A nrPDB Length = 605 Score = 35.0 bits (79), Expect = 0.042, Method: Compositional matrix adjust. Identities = 23/81 (28%), Positives = 37/81 (45%), Gaps = 5/81 (6%) Query: 2 TEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRG 61 TE+M + LK + + TP FP +++ L +D+ NY I Q AL Sbjct: 206 TERMIQKAILKNRIKGLGRDGITPIFPKLVMFVEEG-----VNLYKDDPNYDIKQLALEC 260 Query: 62 HSHFVSDVVISSDGQFALSGS 82 S + +IS+ A++GS Sbjct: 261 ASKRMYPDIISAKNNKAITGS 281 >6EM1-m nrPDB Length = 807 Score = 35.0 bits (79), Expect = 0.045, Method: Compositional matrix adjust. Identities = 14/43 (32%), Positives = 25/43 (58%) Query: 186 TNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLY 228 T + GH G + T+++ P G A+G DG +W++ G+ +Y Sbjct: 431 TIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVY 473 Score = 30.8 bits (68), Expect = 0.90, Method: Compositional matrix adjust. Identities = 15/40 (37%), Positives = 22/40 (55%) Query: 61 GHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRR 100 GH V + I G + +GS DGT+R+W++ TG R Sbjct: 435 GHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYR 474 Score = 30.4 bits (67), Expect = 1.0, Method: Compositional matrix adjust. Identities = 17/71 (23%), Positives = 39/71 (54%), Gaps = 5/71 (7%) Query: 101 FVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTL---GVCKYT-VQDESHSEW-VSCVR 155 + GH V +++ + +GS D T+++W L V + T + DE + ++ + C+ Sbjct: 433 YAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIECIE 492 Query: 156 FSPNSSNPIIV 166 ++P+++N I+ Sbjct: 493 WNPDANNGILA 503 >5WLC-LS nrPDB Length = 594 Score = 34.3 bits (77), Expect = 0.067, Method: Compositional matrix adjust. Identities = 21/75 (28%), Positives = 37/75 (49%), Gaps = 3/75 (4%) Query: 151 VSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTN---HIGHTGYLNTVTVSPDGSLC 207 +S ++FSP+ + S +++ +L +C + +N G + +V SP G L Sbjct: 518 ISNLQFSPDGQILCMASRAVKDALRLVHLPSCSVFSNWPTSGTPLGKVTSVAFSPSGGLL 577 Query: 208 ASGGKDGQAMLWDLN 222 A G + G+ LW LN Sbjct: 578 AVGNEQGKVRLWKLN 592 >6CHG-D nrPDB Length = 439 Score = 33.9 bits (76), Expect = 0.095, Method: Compositional matrix adjust. Identities = 32/113 (28%), Positives = 52/113 (46%), Gaps = 13/113 (11%) Query: 131 LWNTLGVCKYTVQDESHSEWVS----CVRFSPNSSNPIIVSCGWDKLVKVWNLANCK--- 183 L + GV K + +H+ V CV+FSP + + V C + + ++++ + K Sbjct: 6 LQDPFGVLKEYPEKLTHTLEVPVAAVCVKFSPRG-DYLAVGCS-NGAIIIYDMDSLKPIA 63 Query: 184 -LKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGK---HLYTLDG 232 L T+ HT + +V S DG S G+D A LWD+ + Y DG Sbjct: 64 MLGTHSGAHTRSVQSVCWSNDGRYLWSSGRDWYAKLWDMTQPTKCFQQYKFDG 116 Score = 30.4 bits (67), Expect = 1.1, Method: Compositional matrix adjust. Identities = 22/72 (30%), Positives = 35/72 (48%), Gaps = 10/72 (13%) Query: 69 VVISSDGQFALSGSWDGTLRLWDLTT-------GTTTRRFVGHTKDVLSVAFSSDNRQIV 121 V S G + G +G + ++D+ + GT + HT+ V SV +S+D R + Sbjct: 33 VKFSPRGDYLAVGCSNGAIIIYDMDSLKPIAMLGTHSG---AHTRSVQSVCWSNDGRYLW 89 Query: 122 SGSRDKTIKLWN 133 S RD KLW+ Sbjct: 90 SSGRDWYAKLWD 101 Score = 28.5 bits (62), Expect = 4.2, Method: Compositional matrix adjust. Identities = 25/86 (29%), Positives = 41/86 (47%), Gaps = 10/86 (11%) Query: 236 INALC--FSPN-RYWLCAATGPSIKIWDLEGKIIVDELKQ-EVISTSSKAEPPQCTSLAW 291 + A+C FSP Y + +I I+D+ D LK ++ T S A S+ W Sbjct: 28 VAAVCVKFSPRGDYLAVGCSNGAIIIYDM------DSLKPIAMLGTHSGAHTRSVQSVCW 81 Query: 292 SADGQTLFAGYTDNLVRVWQVTIGTR 317 S DG+ L++ D ++W +T T+ Sbjct: 82 SNDGRYLWSSGRDWYAKLWDMTQPTK 107 >3F3P-A nrPDB Length = 351 Score = 33.9 bits (76), Expect = 0.10, Method: Compositional matrix adjust. Identities = 23/79 (29%), Positives = 39/79 (49%), Gaps = 6/79 (7%) Query: 61 GHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTT----TRRFVGHTKDVLSVAFSSD 116 GH V DVV G+ + S D ++++ L T+ + + H ++++ ++S Sbjct: 9 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 68 Query: 117 N--RQIVSGSRDKTIKLWN 133 R I S S DKT+KLW Sbjct: 69 EYGRIIASASYDKTVKLWE 87 Score = 28.1 bits (61), Expect = 4.8, Method: Compositional matrix adjust. Identities = 54/241 (22%), Positives = 92/241 (38%), Gaps = 31/241 (12%) Query: 103 GHTKDVLSVAFSSDNRQIVSGSRDKTIKLWN-TLGVCKYTVQD--ESHSEWVSCVRFSPN 159 GH V V + R + + S D+ IK++ + + D +H + + ++ Sbjct: 9 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 68 Query: 160 SSNPIIVSCGWDKLVKVW----NLANC------KLKTNHIGHTGYLNTVTVSPD--GSLC 207 II S +DK VK+W + C KL T + G L +V +P G Sbjct: 69 EYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLN-DSKGSLYSVKFAPAHLGLKL 127 Query: 208 ASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYW---LCAATGPS------IKI 258 A G DG L+D E L + + L P + C + PS + + Sbjct: 128 ACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAV 187 Query: 259 WDLEGKIIVDELKQEVISTSSK--AEPPQCTSLAWSAD----GQTLFAGYTDNLVRVWQV 312 LE II K + ++K S++W+ Q + G D +R++++ Sbjct: 188 SALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKI 247 Query: 313 T 313 T Sbjct: 248 T 248 Score = 27.3 bits (59), Expect = 9.6, Method: Compositional matrix adjust. Identities = 14/49 (28%), Positives = 26/49 (53%), Gaps = 1/49 (2%) Query: 2 TEQMTLRGTLKGHNGWVTQIA-TTPQFPDMILSASRDKTIIMWKLTRDE 49 T L + + H+ + I +P++ +I SAS DKT+ +W+ D+ Sbjct: 44 TSNWELSDSWRAHDSSIVAIDWASPEYGRIIASASYDKTVKLWEEDPDQ 92 >5WLC-LH nrPDB Length = 896 Score = 33.5 bits (75), Expect = 0.14, Method: Compositional matrix adjust. Identities = 28/103 (27%), Positives = 45/103 (43%), Gaps = 9/103 (8%) Query: 38 KTIIMWKLTRDETNYGIP--------QRALRGHSHFVSDVVISSDGQFALSGSWDGTLRL 89 K+I + L D N P ++L ++ +VS + I + GQ G G + + Sbjct: 223 KSISVVSLFDDSVNLSFPLGSILSSQTQSLSYNTRYVSSMAIDNMGQQLAVGFASGVISI 282 Query: 90 WDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLW 132 L R H VLS++FS D ++SG +K + LW Sbjct: 283 VSLA-DLQIRLLKWHIDSVLSLSFSHDGSYLLSGGWEKVMSLW 324 Score = 32.0 bits (71), Expect = 0.36, Method: Compositional matrix adjust. Identities = 15/40 (37%), Positives = 21/40 (52%) Query: 57 RALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGT 96 R L+ H V + S DG + LSG W+ + LW L T + Sbjct: 291 RLLKWHIDSVLSLSFSHDGSYLLSGGWEKVMSLWQLETNS 330 Score = 28.1 bits (61), Expect = 5.7, Method: Compositional matrix adjust. Identities = 11/19 (57%), Positives = 13/19 (68%) Query: 288 SLAWSADGQTLFAGYTDNL 306 SLAWS DG +F G+ D L Sbjct: 612 SLAWSQDGSLIFHGFDDKL 630 >1PI6-A nrPDB Length = 615 Score = 33.1 bits (74), Expect = 0.16, Method: Compositional matrix adjust. Identities = 52/216 (24%), Positives = 90/216 (41%), Gaps = 36/216 (16%) Query: 10 TLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDV 69 T+ GHN +T + P ++S S D I+ W + + HS+ + + Sbjct: 334 TISGHNKGITALTVNP-----LISGSYDGRIMEWSSSSMHQD----------HSNLIVSL 378 Query: 70 VISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTI 129 S +++ S SWD TL++ G T F G V S ++D V + D + Sbjct: 379 DNSKAQEYS-SISWDDTLKV----NGITKHEF-GSQPKVASA--NNDGFTAVLTNDDDLL 430 Query: 130 KLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCK----LK 185 L + G +V+ S VS S N + V ++V+ L++ + LK Sbjct: 431 ILQSFTGDIIKSVRLNSPGSAVSL------SQNYVAVGLEEGNTIQVFKLSDLEVSFDLK 484 Query: 186 TNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDL 221 T Y +++SP + A+G G+ +L+DL Sbjct: 485 TPLRAKPSY---ISISPSETYIAAGDVMGKILLYDL 517 Score = 29.6 bits (65), Expect = 1.6, Method: Compositional matrix adjust. Identities = 28/108 (25%), Positives = 48/108 (44%), Gaps = 14/108 (12%) Query: 69 VVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKT 128 VV + +G+ +S S DGTL ++L + GH K + ++ + ++SGS D Sbjct: 304 VVATGNGRI-ISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNP----LISGSYDGR 358 Query: 129 IKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKV 176 I W++ + + HS + + NS S WD +KV Sbjct: 359 IMEWSS------SSMHQDHSNLIVSLD---NSKAQEYSSISWDDTLKV 397 >2VDU-B nrPDB Length = 450 Score = 32.3 bits (72), Expect = 0.24, Method: Compositional matrix adjust. Identities = 22/88 (25%), Positives = 41/88 (46%), Gaps = 6/88 (6%) Query: 164 IIVSCGWDKLVKVWNLANCKLKTN-HIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLN 222 I++ D+ +K+ + C + GH +++++ D L ++GG D + WD Sbjct: 212 FIITSDRDEHIKISHYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGG-DDKIFAWDWK 270 Query: 223 EGKHLYTLDGGDII----NALCFSPNRY 246 GK+L T D +I N +P R+ Sbjct: 271 TGKNLSTFDYNSLIKPYLNDQHLAPPRF 298 Score = 28.1 bits (61), Expect = 4.6, Method: Compositional matrix adjust. Identities = 23/83 (27%), Positives = 33/83 (39%), Gaps = 9/83 (10%) Query: 59 LRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHT--------KDVLS 110 L GH HFVS + D LS D + WD TG F ++ + + Sbjct: 237 LFGHKHFVSSICCGKD-YLLLSAGGDDKIFAWDWKTGKNLSTFDYNSLIKPYLNDQHLAP 295 Query: 111 VAFSSDNRQIVSGSRDKTIKLWN 133 F ++N I+ + K IK N Sbjct: 296 PRFQNENNDIIEFAVSKIIKSKN 318 >5A9Q-7 nrPDB Length = 360 Score = 32.3 bits (72), Expect = 0.27, Method: Compositional matrix adjust. Identities = 63/305 (20%), Positives = 117/305 (38%), Gaps = 62/305 (20%) Query: 62 HSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTG---TTTRRFVGHTKDVLSV--AFSSD 116 H + DV G+ + S D ++++WD + T + H+ V V A Sbjct: 11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEF 70 Query: 117 NRQIVSGSRDKTIKLWNTL-GVCKYTVQDESHSEWV------------SCVRFSPNSSNP 163 + + S S D+T +W + G ++ +SH WV + V+F+P Sbjct: 71 GQVLASCSFDRTAAVWEEIVGESNDKLRGQSH--WVKRTTLVDSRTSVTDVKFAPKHMGL 128 Query: 164 IIVSCGWDKLVKV-----------WNLAN---CKLKTNHIGHTGYLNTVTVSPDGSLCAS 209 ++ +C D +V++ W+L + CKL + I N + + A Sbjct: 129 MLATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCIS----WNPSSSRAHSPMIAV 184 Query: 210 GGKD------GQAMLWDLNEGKHLYT-----LDGGDIINALCFSPN---RYWLCAATGPS 255 G D + +++ NE Y + D ++ + F+PN + + A Sbjct: 185 GSDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAIATKD 244 Query: 256 IKIWDLEGKIIVDEL-------KQEV-ISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLV 307 ++I+ L K + EL K E+ I Q ++W+ G L + D V Sbjct: 245 VRIFTL--KPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCV 302 Query: 308 RVWQV 312 R+W+ Sbjct: 303 RLWKA 307 Score = 29.3 bits (64), Expect = 2.6, Method: Compositional matrix adjust. Identities = 19/56 (33%), Positives = 30/56 (53%), Gaps = 6/56 (10%) Query: 12 KGHNGWVTQIA-TTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFV 66 K H+G V ++ P+F ++ S S D+T +W+ E+N LRG SH+V Sbjct: 54 KTHSGSVWRVTWAHPEFGQVLASCSFDRTAAVWEEIVGESN-----DKLRGQSHWV 104 Score = 28.5 bits (62), Expect = 4.1, Method: Compositional matrix adjust. Identities = 21/82 (25%), Positives = 40/82 (48%), Gaps = 3/82 (3%) Query: 99 RRFVGHTKDVL-SVAFSSDNRQIVSGSRDKTIKLWN--TLGVCKYTVQDESHSEWVSCVR 155 R KD++ V+F R++ + S D+++K+W+ G T ++HS V V Sbjct: 5 RSIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVT 64 Query: 156 FSPNSSNPIIVSCGWDKLVKVW 177 ++ ++ SC +D+ VW Sbjct: 65 WAHPEFGQVLASCSFDRTAAVW 86 >5MC6-j nrPDB Length = 397 Score = 31.6 bits (70), Expect = 0.53, Method: Compositional matrix adjust. Identities = 15/48 (31%), Positives = 21/48 (43%) Query: 61 GHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDV 108 HS +V + + G+ S WDG LR WD+ T H D+ Sbjct: 289 AHSSWVMSLSFNDSGETLCSAGWDGKLRFWDVKTKERITTLNMHCDDI 336 Score = 30.8 bits (68), Expect = 0.83, Method: Compositional matrix adjust. Identities = 35/138 (25%), Positives = 60/138 (43%), Gaps = 24/138 (17%) Query: 63 SHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRF------VGHTKDVLSVAFSSD 116 S F + V IS G A +G +GT+++ +L+T F + ++ + SV FS Sbjct: 186 SQFATSVDISERGLIA-TGFNNGTVQISELSTLRPLYNFESQHSMINNSNSIRSVKFSPQ 244 Query: 117 NRQIVSGSRDKT---IKLWNT--------LGVCKYTVQ----DESHSEWVSCVRFSPNSS 161 + + I L+ T L V ++ Q + +HS WV + F N S Sbjct: 245 GSLLAIAHDSNSFGCITLYETEFGERIGSLSVPTHSSQASLGEFAHSSWVMSLSF--NDS 302 Query: 162 NPIIVSCGWDKLVKVWNL 179 + S GWD ++ W++ Sbjct: 303 GETLCSAGWDGKLRFWDV 320 >3DW8-B nrPDB Length = 447 Score = 31.2 bits (69), Expect = 0.63, Method: Compositional matrix adjust. Identities = 36/150 (24%), Positives = 61/150 (40%), Gaps = 27/150 (18%) Query: 31 ILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQF----ALSGSWDGT 86 L ++ DKTI +WK I +R R + + + DG++ ++ Sbjct: 110 FLLSTNDKTIKLWK---------ISERDKRPEGYNLKE----EDGRYRDPTTVTTLRVPV 156 Query: 87 LRLWDLTTGTTTRRFV--GHTKDVLSVAFSSDNRQIVSGSRDKTIKLWN-TLGVCKYTVQ 143 R DL + RR HT + S++ +SD +S D I LW+ + + + Sbjct: 157 FRPMDLMVEASPRRIFANAHTYHINSISINSDYETYLSAD-DLRINLWHLEITDRSFNIV 215 Query: 144 D------ESHSEWVSCVRFSPNSSNPIIVS 167 D E +E ++ F PNS N + S Sbjct: 216 DIKPANMEELTEVITAAEFHPNSCNTFVYS 245 >6F1U-h nrPDB Length = 612 Score = 31.2 bits (69), Expect = 0.64, Method: Compositional matrix adjust. Identities = 28/116 (24%), Positives = 56/116 (48%), Gaps = 13/116 (11%) Query: 164 IIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSP-DGSLCASGGKDGQAMLWDLN 222 + V+ +D VK+W+ N K + + GY+ V SP +L A G+ LW+LN Sbjct: 470 LFVTSSFDWTVKLWSTKNNKPLYSFEDNAGYVYDVMWSPTHPALFACVDGMGRLDLWNLN 529 Query: 223 EGKHLYT----LDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEV 274 + T ++G +N + ++ +G I + D EG+I++ ++ +++ Sbjct: 530 NDTEVPTASISVEGNPALNRVRWT--------HSGREIAVGDSEGQIVIYDVGEQI 577 >3AMK-A nrPDB Length = 702 Score = 31.2 bits (69), Expect = 0.65, Method: Compositional matrix adjust. Identities = 31/137 (22%), Positives = 55/137 (40%), Gaps = 27/137 (19%) Query: 136 GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYL 195 G + + H EW+ R N S +DK + W+L + T+H+ + Y+ Sbjct: 521 GYLNFMGNEFGHPEWIDFPREGNNWS--------YDKCRRQWSLVD----TDHLRYK-YM 567 Query: 196 NTV-----TVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCA 250 N + + S +S + ++ D+NE + + GD++ F PN+ + Sbjct: 568 NAFDQAMNALEEEFSFLSSS----KQIVSDMNEKDKVIVFERGDLVFVFNFHPNKTYKGY 623 Query: 251 ATGPSIKIWDLEGKIIV 267 G DL GK V Sbjct: 624 KVG-----CDLPGKYRV 635 >2IO8-A nrPDB Length = 619 Score = 31.2 bits (69), Expect = 0.67, Method: Compositional matrix adjust. Identities = 15/47 (31%), Positives = 24/47 (51%), Gaps = 2/47 (4%) Query: 37 DKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSW 83 D TI+ W + ++T Y +PQ + G +S + + GQF G W Sbjct: 182 DTTILGWMIQTEDTEYSLPQPEIAGELLKISGARLENKGQF--DGKW 226 >5YZG-2 nrPDB Length = 646 Score = 30.8 bits (68), Expect = 0.73, Method: Compositional matrix adjust. Identities = 21/87 (24%), Positives = 41/87 (47%), Gaps = 5/87 (5%) Query: 54 IPQRALRGHSHFVSDV---VISSDGQFALSGSWDGTLRLWD-LTTGTT-TRRFVGHTKDV 108 +P ++ S+ DV V+ + F ++ S DG ++ W + G + F H + Sbjct: 77 LPSASMYERSYMHRDVITHVVCTKTDFIITASHDGHVKFWKKIEEGIEFVKHFRSHLGVI 136 Query: 109 LSVAFSSDNRQIVSGSRDKTIKLWNTL 135 S+A SS+ S DK +K+++ + Sbjct: 137 ESIAVSSEGALFCSVGDDKAMKVFDVV 163 >4E5Z-B nrPDB Length = 436 Score = 30.8 bits (68), Expect = 0.78, Method: Compositional matrix adjust. Identities = 22/74 (29%), Positives = 31/74 (41%), Gaps = 12/74 (16%) Query: 175 KVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNE----GKHLYTL 230 ++WNL K K H+ LN A+ D +WDL + LY+L Sbjct: 242 ELWNLRMHKKKVTHVA----LNPCC----DWFLATASVDQTVKIWDLRQVRGKASFLYSL 293 Query: 231 DGGDIINALCFSPN 244 +NA CFSP+ Sbjct: 294 PHRHPVNAACFSPD 307 Score = 29.6 bits (65), Expect = 1.6, Method: Compositional matrix adjust. Identities = 22/84 (26%), Positives = 36/84 (42%), Gaps = 10/84 (11%) Query: 11 LKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETN----YGIPQRALRGHSHFV 66 L+ H VT +A P + +AS D+T+ +W L + Y +P H H V Sbjct: 246 LRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLP------HRHPV 299 Query: 67 SDVVISSDGQFALSGSWDGTLRLW 90 + S DG L+ +R++ Sbjct: 300 NAACFSPDGARLLTTDQKSEIRVY 323 >1GFF-1 nrPDB Length = 426 Score = 30.8 bits (68), Expect = 0.78, Method: Compositional matrix adjust. Identities = 15/50 (30%), Positives = 25/50 (50%), Gaps = 2/50 (4%) Query: 149 EWVSCVRFSPNSSN--PIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLN 196 +W++ ++ N+S P+ S GWD + + + LK H GYLN Sbjct: 80 QWINFMKDGVNASPLPPVTCSSGWDSAAYLGTIPSSTLKVPKFLHQGYLN 129 >4AYX-A nrPDB Length = 595 Score = 30.4 bits (67), Expect = 1.0, Method: Compositional matrix adjust. Identities = 15/56 (26%), Positives = 31/56 (55%), Gaps = 2/56 (3%) Query: 229 TLDGGDIINALCFSPNRYWLCAATGPSIKIWDLE--GKIIVDELKQEVISTSSKAE 282 T+D D + LC + +LC A +I+++ ++ G+ IV+ L+ + S+ + E Sbjct: 54 TVDYSDNLTRLCLGLSAVFLCGAAANAIRVYLMQTSGQRIVNRLRTSLFSSILRQE 109 >3I2N-A nrPDB Length = 357 Score = 29.6 bits (65), Expect = 1.6, Method: Compositional matrix adjust. Identities = 16/65 (24%), Positives = 31/65 (47%), Gaps = 7/65 (10%) Query: 76 QFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNR-------QIVSGSRDKT 128 ++ +G + G L +W+L V K++++ +IV+GSRD T Sbjct: 81 RYLATGDFGGNLHIWNLEAPEMPVYSVKGHKEIINAIDGIGGLGIGEGAPEIVTGSRDGT 140 Query: 129 IKLWN 133 +K+W+ Sbjct: 141 VKVWD 145 >5WT2-A nrPDB Length = 401 Score = 29.3 bits (64), Expect = 2.5, Method: Compositional matrix adjust. Identities = 11/21 (52%), Positives = 16/21 (76%) Query: 202 PDGSLCASGGKDGQAMLWDLN 222 P+ +L + G +G+AMLWDLN Sbjct: 296 PNTTLVSVRGIEGEAMLWDLN 316 >5WLC-LW nrPDB Length = 554 Score = 27.7 bits (60), Expect = 6.1, Method: Compositional matrix adjust. Identities = 14/67 (20%), Positives = 29/67 (43%) Query: 193 GYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAAT 252 G +N++ + G A+ G D +WD+ K L++++ + L + Sbjct: 275 GPVNSIAIDRSGYYMATTGADRSMKIWDIRNFKQLHSVESLPTPGTNVSISDTGLLALSR 334 Query: 253 GPSIKIW 259 GP + +W Sbjct: 335 GPHVTLW 341 >5A9Q-0 nrPDB Length = 380 Score = 27.3 bits (59), Expect = 8.9, Method: Compositional matrix adjust. Identities = 27/114 (23%), Positives = 48/114 (42%), Gaps = 8/114 (7%) Query: 116 DNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVK 175 +N +IV+ D I L+ D + S + V F P I++ +K Sbjct: 140 NNPEIVTVGEDGRINLFRADHKEAVRTIDNADSSTLHAVTFL---RTPEILTVNSIGQLK 196 Query: 176 VWNLANCKLKTNHI----GHTGYLNTVTVSPDGS-LCASGGKDGQAMLWDLNEG 224 +W+ + + I G L+ V P+ + A+GG+DG +WD+ +G Sbjct: 197 IWDFRQQGNEPSQILSLTGDRVPLHCVDRHPNQQHVVATGGQDGMLSIWDVRQG 250 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 6G51-g nrPDB 412 e-115 4V6W-Ag nrPDB 370 e-103 3DM0-A nrPDB 359 e-100 5OPT-p nrPDB 323 4e-89 4V8M-A7 nrPDB 321 2e-88 6HHQ-h nrPDB 309 1e-84 3JAP-g nrPDB 299 9e-82 4BTS-AR nrPDB 276 7e-75 5MZH-A nrPDB 260 8e-70 1VYH-C nrPDB 258 3e-69 5XYI-g nrPDB 253 7e-68 5NNZ-B nrPDB 250 7e-67 5M25-A nrPDB 237 6e-63 5FL8-q nrPDB 231 3e-61 6HQA-B nrPDB 230 7e-61 2H9P-A nrPDB 228 4e-60 6ID0-T nrPDB 223 7e-59 6F3T-A nrPDB 214 3e-56 5Y88-O nrPDB 210 6e-55 6MZM-G nrPDB 210 6e-55 6QX9-5O nrPDB 205 2e-53 6QX9-4B nrPDB 201 3e-52 6N9G-C nrPDB 201 4e-52 4V7E-Bg nrPDB 198 2e-51 5WLC-LO nrPDB 198 3e-51 5UZ7-B nrPDB 197 4e-51 5G04-R nrPDB 196 7e-51 5I2T-A nrPDB 195 2e-50 5YZG-W nrPDB 192 1e-49 5FVM-C nrPDB 192 1e-49 4GGA-A nrPDB 192 1e-49 6QDV-o nrPDB 192 1e-49 5Z56-q nrPDB 192 2e-49 5L9T-R nrPDB 191 4e-49 5LCW-Q nrPDB 190 6e-49 5NZU-C nrPDB 189 2e-48 6EMK-B nrPDB 187 6e-48 4LG8-A nrPDB 185 2e-47 4N14-A nrPDB 184 4e-47 5WBU-D nrPDB 183 8e-47 5GAN-H nrPDB 182 1e-46 6GMH-W nrPDB 178 2e-45 4AEZ-A nrPDB 176 1e-44 5WYJ-BC nrPDB 175 2e-44 3FM0-A nrPDB 175 3e-44 4J0W-A nrPDB 174 4e-44 6Q8F-A nrPDB 171 3e-43 3MKQ-A nrPDB 171 5e-43 5K1B-B nrPDB 170 7e-43 4YCZ-A nrPDB 169 1e-42 3CFV-B nrPDB 168 3e-42 5WJC-A nrPDB 167 4e-42 3C9C-A nrPDB 167 4e-42 2YNP-A nrPDB 166 2e-41 5Y1U-A nrPDB 165 2e-41 6EOJ-D nrPDB 165 2e-41 5A31-R nrPDB 163 9e-41 5WYK-BB nrPDB 162 1e-40 5OQL-d nrPDB 161 4e-40 3JB9-g nrPDB 161 4e-40 3JRO-A nrPDB 161 5e-40 4BH6-A nrPDB 160 6e-40 5K0Y-T nrPDB 160 8e-40 4L9O-A nrPDB 157 8e-39 5MWJ-A nrPDB 156 2e-38 5OQL-J nrPDB 156 2e-38 6J6H-n nrPDB 153 9e-38 3JRP-A nrPDB 151 5e-37 3JB9-L nrPDB 149 2e-36 4BZK-B nrPDB 147 8e-36 4XYI-A nrPDB 145 3e-35 3BG0-A nrPDB 136 1e-32 5WYJ-BE nrPDB 136 1e-32 1NR0-A nrPDB 135 2e-32 2HES-X nrPDB 134 4e-32 5OQL-L nrPDB 134 6e-32 5OQL-X nrPDB 134 6e-32 5WLC-LU nrPDB 133 1e-31 3ODT-A nrPDB 132 2e-31 6BX3-A nrPDB 131 5e-31 4PSX-B nrPDB 130 5e-31 5WLC-LJ nrPDB 130 8e-31 4U1E-I nrPDB 130 9e-31 5M89-A nrPDB 127 6e-30 4A11-B nrPDB 127 8e-30 2AQ5-A nrPDB 126 1e-29 6CHG-A nrPDB 123 1e-28 5FA5-B nrPDB 119 2e-27 6ELZ-p nrPDB 117 5e-27 4G56-B nrPDB 113 1e-25 5WLC-SG nrPDB 111 4e-25 4J0X-A nrPDB 110 6e-25 3JZG-A nrPDB 106 1e-23 5WLC-LN nrPDB 105 2e-23 5K19-A nrPDB 105 2e-23 3ACP-A nrPDB 105 3e-23 5BJS-A nrPDB 100 8e-22 6E29-D nrPDB 100 1e-21 2PM9-A nrPDB 95 3e-20 4OWR-A nrPDB 95 5e-20 5CXB-B nrPDB 92 3e-19 3JB9-S nrPDB 92 3e-19 5LTD-A nrPDB 66 2e-11 Sequences not found previously or not previously below threshold: 4XFV-A nrPDB 115 2e-26 5A9Q-7 nrPDB 112 2e-25 5N4A-A nrPDB 112 2e-25 3F3P-A nrPDB 107 8e-24 5CXC-A nrPDB 103 8e-23 4E5Z-B nrPDB 100 1e-21 3W15-A nrPDB 100 2e-21 1PI6-A nrPDB 97 7e-21 5OV3-A nrPDB 96 2e-20 6F1U-h nrPDB 96 2e-20 5YZG-2 nrPDB 94 9e-20 5A9Q-2 nrPDB 89 2e-18 6EM1-m nrPDB 89 3e-18 3EI3-B nrPDB 88 4e-18 6C0F-s nrPDB 88 5e-18 6CB1-s nrPDB 87 8e-18 6BX3-B nrPDB 86 3e-17 2P9P-C nrPDB 86 3e-17 3I2N-A nrPDB 79 2e-15 6CHG-D nrPDB 79 2e-15 5MC6-j nrPDB 77 8e-15 5WLC-LW nrPDB 73 2e-13 5TF2-A nrPDB 72 3e-13 5AJA-A nrPDB 72 4e-13 2I3T-A nrPDB 68 5e-12 3DWL-C nrPDB 67 1e-11 5A9Q-0 nrPDB 67 1e-11 2VDU-B nrPDB 62 2e-10 3DW8-B nrPDB 61 6e-10 5AMS-A nrPDB 59 4e-09 6CVZ-A nrPDB 58 5e-09 5WLC-LS nrPDB 58 5e-09 6IYY-A nrPDB 52 4e-07 6N8P-A nrPDB 51 5e-07 5WLC-LH nrPDB 50 1e-06 5K1H-B nrPDB 50 1e-06 4AV8-A nrPDB 49 2e-06 4FHN-A nrPDB 49 3e-06 5CWW-B nrPDB 48 7e-06 5WLC-LV nrPDB 48 7e-06 3WJ9-A nrPDB 47 1e-05 4NOX-A nrPDB 45 5e-05 5BPT-A nrPDB 44 1e-04 4MHC-A nrPDB 42 4e-04 5BPW-A nrPDB 40 0.001 4YHC-A nrPDB 40 0.001 4IMM-A nrPDB 40 0.001 5GRS-A nrPDB 40 0.002 5TXC-A nrPDB 39 0.004 2EEP-A nrPDB 38 0.006 5LJ5-t nrPDB 37 0.009 5WLC-LL nrPDB 37 0.013 4ZB4-A nrPDB 37 0.015 1FLG-A nrPDB 35 0.030 3TKN-A nrPDB 35 0.061 6BN7-A nrPDB 34 0.12 6IGB-A nrPDB 34 0.13 3AZQ-A nrPDB 33 0.18 2QT9-A nrPDB 33 0.20 5SUM-A nrPDB 32 0.42 5WLC-LK nrPDB 31 0.89 5JRK-A nrPDB 30 0.99 4IQB-A nrPDB 30 1.0 4Q1V-A nrPDB 30 1.4 4R40-A nrPDB 30 1.4 3R3L-A nrPDB 30 1.5 3MWP-A nrPDB 30 1.5 1MG2-A nrPDB 30 1.6 5AYI-A nrPDB 29 2.5 2FTW-A nrPDB 29 2.5 1C5K-A nrPDB 29 2.6 1YJS-A nrPDB 29 2.6 6IDE-A nrPDB 29 2.7 2J04-A nrPDB 29 2.7 1JOF-A nrPDB 29 2.8 1K3I-A nrPDB 29 3.1 3MUN-A nrPDB 29 3.2 6IGR-A nrPDB 29 3.3 2Z67-A nrPDB 28 4.7 1Z68-A nrPDB 28 4.9 6FTI-5 nrPDB 28 6.2 4KQP-A nrPDB 28 6.3 5OLJ-A nrPDB 28 7.3 3THY-A nrPDB 27 7.7 2GBG-A nrPDB 27 7.9 >6G51-g nrPDB Length = 317 Score = 412 bits (1058), Expect = e-115, Method: Composition-based stats. Identities = 317/317 (100%), Positives = 317/317 (100%) Query: 1 MTEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALR 60 MTEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALR Sbjct: 1 MTEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALR 60 Query: 61 GHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQI 120 GHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQI Sbjct: 61 GHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQI 120 Query: 121 VSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLA 180 VSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLA Sbjct: 121 VSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLA 180 Query: 181 NCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALC 240 NCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALC Sbjct: 181 NCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALC 240 Query: 241 FSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFA 300 FSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFA Sbjct: 241 FSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFA 300 Query: 301 GYTDNLVRVWQVTIGTR 317 GYTDNLVRVWQVTIGTR Sbjct: 301 GYTDNLVRVWQVTIGTR 317 >4V6W-Ag nrPDB Length = 318 Score = 370 bits (950), Expect = e-103, Method: Composition-based stats. Identities = 243/314 (77%), Positives = 274/314 (87%), Gaps = 1/314 (0%) Query: 1 MTEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDE-TNYGIPQRAL 59 M+E + LRGTL GHNGWVTQIAT P+ PD I+SASRDKT+I+WKLTRDE TNYG PQ+ L Sbjct: 1 MSETLQLRGTLIGHNGWVTQIATNPKDPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRL 60 Query: 60 RGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQ 119 GHSHF+SDVV+SSDG +ALSGSWD TLRLWDL G TTRRF GHTKDVLSVAFS+DNRQ Sbjct: 61 YGHSHFISDVVLSSDGNYALSGSWDQTLRLWDLAAGKTTRRFEGHTKDVLSVAFSADNRQ 120 Query: 120 IVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNL 179 IVSGSRDKTIKLWNTL CK+T+Q++ H++WVSCVRFSPN SNPIIVSCGWD+ VKVWNL Sbjct: 121 IVSGSRDKTIKLWNTLAECKFTIQEDGHTDWVSCVRFSPNHSNPIIVSCGWDRTVKVWNL 180 Query: 180 ANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINAL 239 ANCKLK NH GH GYLNTVTVSPDGSLC SGGKD +A+LWDLN+GK+LYTL+ DIINAL Sbjct: 181 ANCKLKNNHHGHNGYLNTVTVSPDGSLCTSGGKDSKALLWDLNDGKNLYTLEHNDIINAL 240 Query: 240 CFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLF 299 CFSPNRYWLC A GPSIKIWDL K V+EL+ EV+S +SKA+ PQC SLAWS DGQTLF Sbjct: 241 CFSPNRYWLCVAYGPSIKIWDLACKKTVEELRPEVVSPTSKADQPQCLSLAWSTDGQTLF 300 Query: 300 AGYTDNLVRVWQVT 313 AGY+DN +RVWQV+ Sbjct: 301 AGYSDNTIRVWQVS 314 Score = 131 bits (330), Expect = 3e-31, Method: Composition-based stats. Identities = 58/235 (24%), Positives = 93/235 (39%), Gaps = 22/235 (9%) Query: 93 TTGTTTRRFVGHTKDVLSVAFSS-DNRQIVSGSRDKTIKLWNTLGVCKYTV-----QDES 146 T +GH V +A + D I+S SRDKT+ +W + Sbjct: 3 ETLQLRGTLIGHNGWVTQIATNPKDPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRLYG 62 Query: 147 HSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSL 206 HS ++S V S S +S WD+ +++W+LA K GHT + +V S D Sbjct: 63 HSHFISDVVLS--SDGNYALSGSWDQTLRLWDLAAGKTTRRFEGHTKDVLSVAFSADNRQ 120 Query: 207 CASGGKDGQAMLWD-LNEGKHLYTLDGG-DIINALCFSPNRY---WLCAATGPSIKIWDL 261 SG +D LW+ L E K DG D ++ + FSPN + ++K+W+L Sbjct: 121 IVSGSRDKTIKLWNTLAECKFTIQEDGHTDWVSCVRFSPNHSNPIIVSCGWDRTVKVWNL 180 Query: 262 EGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGT 316 + + ++ S DG +G D+ +W + G Sbjct: 181 ANCKLKNN---------HHGHNGYLNTVTVSPDGSLCTSGGKDSKALLWDLNDGK 226 >3DM0-A nrPDB Length = 694 Score = 359 bits (922), Expect = e-100, Method: Composition-based stats. Identities = 209/321 (65%), Positives = 248/321 (77%), Gaps = 12/321 (3%) Query: 5 MTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSH 64 + L+GT++ H VT IAT D+I+SASRDK+II+WKLT+D+ YG+ QR L GHSH Sbjct: 372 LVLKGTMRAHTDMVTAIATPIDNADIIVSASRDKSIILWKLTKDDKAYGVAQRRLTGHSH 431 Query: 65 FVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGS 124 FV DVV+SSDGQFALSGSWDG LRLWDL G +TRRFVGHTKDVLSVAFS DNRQIVS S Sbjct: 432 FVEDVVLSSDGQFALSGSWDGELRLWDLAAGVSTRRFVGHTKDVLSVAFSLDNRQIVSAS 491 Query: 125 RDKTIKLWNTLGVCKYTVQD--ESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANC 182 RD+TIKLWNTLG CKYT+ + E H +WVSCVRFSPN+ P IVS WDK VKVWNL+NC Sbjct: 492 RDRTIKLWNTLGECKYTISEGGEGHRDWVSCVRFSPNTLQPTIVSASWDKTVKVWNLSNC 551 Query: 183 KLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFS 242 KL++ GHTGY++TV VSPDGSLCASGGKDG +LWDL EGK LY+L+ +I+ALCFS Sbjct: 552 KLRSTLAGHTGYVSTVAVSPDGSLCASGGKDGVVLLWDLAEGKKLYSLEANSVIHALCFS 611 Query: 243 PNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPP----------QCTSLAWS 292 PNRYWLCAAT IKIWDLE K IV++LK ++ + + KA+ CTSL WS Sbjct: 612 PNRYWLCAATEHGIKIWDLESKSIVEDLKVDLKAEAEKADNSGPAATKRKVIYCTSLNWS 671 Query: 293 ADGQTLFAGYTDNLVRVWQVT 313 ADG TLF+GYTD ++RVW + Sbjct: 672 ADGSTLFSGYTDGVIRVWGIG 692 Score = 149 bits (375), Expect = 2e-36, Method: Composition-based stats. Identities = 60/231 (25%), Positives = 96/231 (41%), Gaps = 25/231 (10%) Query: 100 RFVGHTKDVLSVAFSSDN-RQIVSGSRDKTIKLW----NTLGVCKYTVQDESHSEWVSCV 154 HT V ++A DN IVS SRDK+I LW + + HS +V V Sbjct: 377 TMRAHTDMVTAIATPIDNADIIVSASRDKSIILWKLTKDDKAYGVAQRRLTGHSHFVEDV 436 Query: 155 RFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDG 214 S S +S WD +++W+LA +GHT + +V S D S +D Sbjct: 437 VLS--SDGQFALSGSWDGELRLWDLAAGVSTRRFVGHTKDVLSVAFSLDNRQIVSASRDR 494 Query: 215 QAMLWDLNEGKHLYTLD-----GGDIINALCFSPNR---YWLCAATGPSIKIWDLEGKII 266 LW+ G+ YT+ D ++ + FSPN + A+ ++K+W+L + Sbjct: 495 TIKLWN-TLGECKYTISEGGEGHRDWVSCVRFSPNTLQPTIVSASWDKTVKVWNLSNCKL 553 Query: 267 VDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGTR 317 L +++A S DG +G D +V +W + G + Sbjct: 554 RSTL---------AGHTGYVSTVAVSPDGSLCASGGKDGVVLLWDLAEGKK 595 >5OPT-p nrPDB Length = 318 Score = 323 bits (829), Expect = 4e-89, Method: Composition-based stats. Identities = 172/317 (54%), Positives = 220/317 (69%), Gaps = 10/317 (3%) Query: 5 MTLRGTLKGHNGWVTQIATTPQFPDMIL---SASRDKTIIMW----KLTRDETNYGIPQR 57 + G LKGH GWVT +A PQ + + S SRD T+I W +E YG P+R Sbjct: 3 VVYEGQLKGHRGWVTALA-CPQITETYIKAVSTSRDNTLIAWGSNMDRNSEECEYGFPER 61 Query: 58 ALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDN 117 L GHS FVSDV +S++G FA+S SWD +LRLW+L TG +F+GHTKDVLSV FS DN Sbjct: 62 RLEGHSAFVSDVALSNNGDFAVSASWDHSLRLWNLQTGVCQHKFLGHTKDVLSVTFSPDN 121 Query: 118 RQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVW 177 RQIVSG RD +++WN G C +T+ +H++WVSCVRFSP+ P+IVS GWD LVKVW Sbjct: 122 RQIVSGGRDNALRVWNVKGECLHTLGRGAHTDWVSCVRFSPSLETPLIVSGGWDNLVKVW 181 Query: 178 NLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIIN 237 ++A+ +L T+ GHT Y+ +VTVSPDGSLCAS KDG A LWDL +G+ L + G IN Sbjct: 182 DIASGRLLTDLKGHTNYITSVTVSPDGSLCASSDKDGVARLWDLTKGEALSEMAAGAPIN 241 Query: 238 ALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQT 297 +CFSPNRYW+CAAT I+I+DLE K ++ EL E S K P+C S+AWSADG T Sbjct: 242 QICFSPNRYWMCAATEKGIRIFDLENKDVIVELAPEAQQKSKK--TPECMSIAWSADGNT 299 Query: 298 LFAGYTDNLVRVWQVTI 314 L++GYTDN++RVW V+ Sbjct: 300 LYSGYTDNVIRVWSVSE 316 Score = 135 bits (341), Expect = 2e-32, Method: Composition-based stats. Identities = 63/233 (27%), Positives = 100/233 (42%), Gaps = 29/233 (12%) Query: 100 RFVGHTKDVLSVAFSS-DNRQI--VSGSRDKTIKLWNTLGVCK--------YTVQDESHS 148 + GH V ++A I VS SRD T+ W + + E HS Sbjct: 8 QLKGHRGWVTALACPQITETYIKAVSTSRDNTLIAWGSNMDRNSEECEYGFPERRLEGHS 67 Query: 149 EWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCA 208 +VS V S N VS WD +++WNL + +GHT + +VT SPD Sbjct: 68 AFVSDVALSNNGD--FAVSASWDHSLRLWNLQTGVCQHKFLGHTKDVLSVTFSPDNRQIV 125 Query: 209 SGGKDGQAMLWDLNEGKHLYTL---DGGDIINALCFSPN---RYWLCAATGPSIKIWDLE 262 SGG+D +W++ +G+ L+TL D ++ + FSP+ + +K+WD+ Sbjct: 126 SGGRDNALRVWNV-KGECLHTLGRGAHTDWVSCVRFSPSLETPLIVSGGWDNLVKVWDIA 184 Query: 263 GKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIG 315 ++ +LK TS+ S DG + D + R+W +T G Sbjct: 185 SGRLLTDLK---------GHTNYITSVTVSPDGSLCASSDKDGVARLWDLTKG 228 Score = 105 bits (262), Expect = 3e-23, Method: Composition-based stats. Identities = 39/189 (20%), Positives = 78/189 (41%), Gaps = 24/189 (12%) Query: 143 QDESHSEWVSCVRFSPNSSNPII--VSCGWDKLVKVW----NLANCKLK-----TNHIGH 191 Q + H WV+ + P + I VS D + W + + + + GH Sbjct: 8 QLKGHRGWVTALAC-PQITETYIKAVSTSRDNTLIAWGSNMDRNSEECEYGFPERRLEGH 66 Query: 192 TGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGD-IINALCFSP-NRYWLC 249 + +++ V +S +G S D LW+L G + G + ++ FSP NR + Sbjct: 67 SAFVSDVALSNNGDFAVSASWDHSLRLWNLQTGVCQHKFLGHTKDVLSVTFSPDNRQIVS 126 Query: 250 AATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSA--DGQTLFAGYTDNLV 307 ++++W+++G+ + + A + + +S + + +G DNLV Sbjct: 127 GGRDNALRVWNVKGECLH--------TLGRGAHTDWVSCVRFSPSLETPLIVSGGWDNLV 178 Query: 308 RVWQVTIGT 316 +VW + G Sbjct: 179 KVWDIASGR 187 >4V8M-A7 nrPDB Length = 318 Score = 321 bits (823), Expect = 2e-88, Method: Composition-based stats. Identities = 174/318 (54%), Positives = 221/318 (69%), Gaps = 8/318 (2%) Query: 5 MTLRGTLKGHNGWVTQIAT--TPQFPDMILSASRDKTIIMWKLTRD----ETNYGIPQRA 58 + G L GH GWVT +A TP+ ++S SRDKT++ W D E +YG+P R Sbjct: 3 VAYEGQLTGHRGWVTSLACPQTPETATKVVSTSRDKTLLSWGPNPDRHSSECSYGLPDRR 62 Query: 59 LRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNR 118 L GHS FVSDV +S++G FA+S SWD +LRLW+L G +F+GHTKDVLSVAFS DNR Sbjct: 63 LEGHSAFVSDVALSNNGNFAVSASWDHSLRLWNLQNGQCQYKFLGHTKDVLSVAFSPDNR 122 Query: 119 QIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWN 178 QIVSG RD +++WN G C +T+ +H++WVSCVRFSP+ P+IVS GWD LVKVW+ Sbjct: 123 QIVSGGRDNALRVWNVKGECMHTLSRGAHTDWVSCVRFSPSLDAPVIVSGGWDNLVKVWD 182 Query: 179 LANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINA 238 LA +L T+ GHT Y+ +VTVSPDGSLCAS KDG A LWDL +G+ L + G IN Sbjct: 183 LATGRLVTDLKGHTNYVTSVTVSPDGSLCASSDKDGVARLWDLTKGEALSEMAAGAPINQ 242 Query: 239 LCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTL 298 +CFSPNRYW+CAAT I+I+DLE K I+ EL E SK P+C S+AWSADG TL Sbjct: 243 ICFSPNRYWMCAATEKGIRIFDLENKDIIVELAPE--HQGSKKIVPECVSIAWSADGSTL 300 Query: 299 FAGYTDNLVRVWQVTIGT 316 ++GYTDN++RVW V+ Sbjct: 301 YSGYTDNVIRVWGVSENA 318 >6HHQ-h nrPDB Length = 319 Score = 309 bits (791), Expect = 1e-84, Method: Composition-based stats. Identities = 169/317 (53%), Positives = 218/317 (68%), Gaps = 7/317 (2%) Query: 3 EQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGH 62 E + LRGTL+GHNGWVT +AT+ P+++LSASRDKT+I WKLT D+ +G+P R+ +GH Sbjct: 5 EVLVLRGTLEGHNGWVTSLATSAGQPNLLLSASRDKTLISWKLTGDDQKFGVPVRSFKGH 64 Query: 63 SHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVS 122 SH V D +++DG +ALS SWD TLRLWD+ TG T +RFVGH DV+SV I+S Sbjct: 65 SHIVQDCTLTADGAYALSASWDKTLRLWDVATGETYQRFVGHKSDVMSVDIDKKASMIIS 124 Query: 123 GSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPN----SSNPIIVSCGWDKLVKVWN 178 GSRDKTIK+W G C T+ H++WVS VR PN + I+S G DK+VK WN Sbjct: 125 GSRDKTIKVWTIKGQCLATLL--GHNDWVSQVRVVPNEKADDDSVTIISAGNDKMVKAWN 182 Query: 179 LANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINA 238 L +++ + IGH +NT+T SPDG+L AS GKDG+ MLW+L K +YTL D + + Sbjct: 183 LNQFQIEADFIGHNSNINTLTASPDGTLIASAGKDGEIMLWNLAAKKAMYTLSAQDEVFS 242 Query: 239 LCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTL 298 L FSPNRYWL AAT IK++ L+ + +VD+L+ E S AEP SLAWSADGQTL Sbjct: 243 LAFSPNRYWLAAATATGIKVFSLDPQYLVDDLRPEFAGYSKAAEPHAV-SLAWSADGQTL 301 Query: 299 FAGYTDNLVRVWQVTIG 315 FAGYTDN++RVWQV Sbjct: 302 FAGYTDNVIRVWQVMTA 318 Score = 124 bits (310), Expect = 7e-29, Method: Composition-based stats. Identities = 50/230 (21%), Positives = 88/230 (38%), Gaps = 25/230 (10%) Query: 100 RFVGHTKDVLSVAFSSDN-RQIVSGSRDKTIKLWNTLGVCK----YTVQDESHSEWVSCV 154 GH V S+A S+ ++S SRDKT+ W G + + HS V Sbjct: 12 TLEGHNGWVTSLATSAGQPNLLLSASRDKTLISWKLTGDDQKFGVPVRSFKGHSHIVQDC 71 Query: 155 RFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDG 214 + +S WDK +++W++A + +GH + +V + S+ SG +D Sbjct: 72 TL--TADGAYALSASWDKTLRLWDVATGETYQRFVGHKSDVMSVDIDKKASMIISGSRDK 129 Query: 215 QAMLWDLNEGKHLYTLDGG-DIINALCFSPNR-------YWLCAATGPSIKIWDLEGKII 266 +W + +G+ L TL G D ++ + PN + A +K W+L I Sbjct: 130 TIKVWTI-KGQCLATLLGHNDWVSQVRVVPNEKADDDSVTIISAGNDKMVKAWNLNQFQI 188 Query: 267 VDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGT 316 + +L S DG + + D + +W + Sbjct: 189 EADF---------IGHNSNINTLTASPDGTLIASAGKDGEIMLWNLAAKK 229 Score = 72.4 bits (176), Expect = 3e-13, Method: Composition-based stats. Identities = 37/184 (20%), Positives = 57/184 (30%), Gaps = 60/184 (32%) Query: 9 GTLKGHNGWVTQIATTP-----QFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHS 63 TL GHN WV+Q+ P I+SA DK + W L + + GH+ Sbjct: 142 ATLLGHNDWVSQVRVVPNEKADDDSVTIISAGNDKMVKAWNLNQFQIEAD-----FIGHN 196 Query: 64 HFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSS-------- 115 ++ + S DG S DG + LW+L +V S+AFS Sbjct: 197 SNINTLTASPDGTLIASAGKDGEIMLWNLAAKKAMYTLSA-QDEVFSLAFSPNRYWLAAA 255 Query: 116 -----------------------------------------DNRQIVSGSRDKTIKLWNT 134 D + + +G D I++W Sbjct: 256 TATGIKVFSLDPQYLVDDLRPEFAGYSKAAEPHAVSLAWSADGQTLFAGYTDNVIRVWQV 315 Query: 135 LGVC 138 + Sbjct: 316 MTAN 319 Score = 28.9 bits (63), Expect = 2.9, Method: Composition-based stats. Identities = 11/45 (24%), Positives = 19/45 (42%), Gaps = 1/45 (2%) Query: 274 VISTSSKAEPPQCTSLAWSA-DGQTLFAGYTDNLVRVWQVTIGTR 317 V+ + + TSLA SA L + D + W++T + Sbjct: 8 VLRGTLEGHNGWVTSLATSAGQPNLLLSASRDKTLISWKLTGDDQ 52 >3JAP-g nrPDB Length = 326 Score = 299 bits (766), Expect = 9e-82, Method: Composition-based stats. Identities = 163/321 (50%), Positives = 223/321 (69%), Gaps = 13/321 (4%) Query: 5 MTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSH 64 + LRGTL+GHNGWVT ++T+ P++++S SRDKT+I W+LT +E +G+P R+ +GHSH Sbjct: 8 LVLRGTLEGHNGWVTSLSTSAAQPNLLVSGSRDKTLISWRLTENEQQFGVPVRSYKGHSH 67 Query: 65 FVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGS 124 V DVV+S+DG +A+S SWD TLRLW+L TG + RFVGHT DVLSVA +++ +I+S S Sbjct: 68 IVQDVVVSADGNYAVSASWDKTLRLWNLATGNSEARFVGHTGDVLSVAIDANSSKIISAS 127 Query: 125 RDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSP--------NSSNPIIVSCGWDKLVKV 176 RDKTI++WNT+G C Y + H++WV+ VR +P + VS G DK+V+ Sbjct: 128 RDKTIRVWNTVGDCAYVLL--GHTDWVTKVRVAPKNLEDGEVDDGRITFVSAGMDKIVRS 185 Query: 177 WNLA--NCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGD 234 W+L + +++ + IGH Y+N V SPDGSL AS GKDGQ +W+L D D Sbjct: 186 WSLNEDSYRIEADFIGHNNYINVVQPSPDGSLAASAGKDGQIYVWNLKHKSAFMNFDAKD 245 Query: 235 IINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSAD 294 + AL FSP+R+WL AAT IKI+DLE ++++DELK E + +KA+ P SLAWSAD Sbjct: 246 EVFALAFSPSRFWLTAATASGIKIYDLENEVLIDELKPE-FAGYTKAQDPHAVSLAWSAD 304 Query: 295 GQTLFAGYTDNLVRVWQVTIG 315 GQTLFAGYTDN++RVWQV Sbjct: 305 GQTLFAGYTDNVIRVWQVMTA 325 Score = 65.1 bits (157), Expect = 4e-11, Method: Composition-based stats. Identities = 38/186 (20%), Positives = 64/186 (34%), Gaps = 60/186 (32%) Query: 10 TLKGHNGWVTQIATTPQFPD---------MILSASRDKTIIMWKLTRDETNYGIPQRALR 60 L GH WVT++ P+ + +SA DK + W L D + Sbjct: 144 VLLGHTDWVTKVRVAPKNLEDGEVDDGRITFVSAGMDKIVRSWSLNED---SYRIEADFI 200 Query: 61 GHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTG------------------------- 95 GH+++++ V S DG A S DG + +W+L Sbjct: 201 GHNNYINVVQPSPDGSLAASAGKDGQIYVWNLKHKSAFMNFDAKDEVFALAFSPSRFWLT 260 Query: 96 -------------------TTTRRFVGHTKD----VLSVAFSSDNRQIVSGSRDKTIKLW 132 F G+TK +S+A+S+D + + +G D I++W Sbjct: 261 AATASGIKIYDLENEVLIDELKPEFAGYTKAQDPHAVSLAWSADGQTLFAGYTDNVIRVW 320 Query: 133 NTLGVC 138 + Sbjct: 321 QVMTAN 326 Score = 31.6 bits (70), Expect = 0.45, Method: Composition-based stats. Identities = 11/45 (24%), Positives = 20/45 (44%), Gaps = 1/45 (2%) Query: 274 VISTSSKAEPPQCTSLAWSA-DGQTLFAGYTDNLVRVWQVTIGTR 317 V+ + + TSL+ SA L +G D + W++T + Sbjct: 9 VLRGTLEGHNGWVTSLSTSAAQPNLLVSGSRDKTLISWRLTENEQ 53 >4BTS-AR nrPDB Length = 343 Score = 276 bits (707), Expect = 7e-75, Method: Composition-based stats. Identities = 145/332 (43%), Positives = 205/332 (61%), Gaps = 22/332 (6%) Query: 4 QMTLRGTLKGHNGWVTQIAT-----TPQFPDMILSASRDKTIIMWKLTRDETN--YGIPQ 56 Q+ RG L+GH+ WVT I + +++S SRDKT+++WKL +E N +GIP Sbjct: 10 QVVKRGILEGHSDWVTSIVAGFSQKENEDSPVLISGSRDKTVMIWKLYEEEQNGYFGIPH 69 Query: 57 RALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSD 116 +AL GH+HFVSD+ +S + FA+S SWD TLRLWDL TGTT +RFVGH +V SVAFS D Sbjct: 70 KALTGHNHFVSDLALSQENCFAISSSWDKTLRLWDLRTGTTYKRFVGHQSEVYSVAFSPD 129 Query: 117 NRQIVSGSRDKTIKLWNTLGVCKY-TVQDESHSEWVSCVRFSPNSSN--------PIIVS 167 NRQI+S ++ IKLWN LG CK+ + + E+HS+WVSCVR+SP + P S Sbjct: 130 NRQILSAGAEREIKLWNILGECKFSSAEKENHSDWVSCVRYSPIMKSANKVQPFAPYFAS 189 Query: 168 CGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWD-LNEGKH 226 GWD +KVWN N +++ H +N +++SP+G A+GGKD + ++WD LN Sbjct: 190 VGWDGRLKVWN-TNFQIRYTFKAHESNVNHLSISPNGKYIATGGKDKKLLIWDILNLTYP 248 Query: 227 LYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDL--EGKIIVDELKQEVIS--TSSKAE 282 D G IN + F+P W+ T +KI++L + K V ++ E I+ K + Sbjct: 249 QREFDAGSTINQIAFNPKLQWVAVGTDQGVKIFNLMTQSKAPVCTIEAEPITKAEGQKGK 308 Query: 283 PPQCTSLAWSADGQTLFAGYTDNLVRVWQVTI 314 PQCTSLAW+A G+ LFAG+TD ++R + Sbjct: 309 NPQCTSLAWNALGKKLFAGFTDGVIRTFSFET 340 Score = 112 bits (279), Expect = 3e-25, Method: Composition-based stats. Identities = 52/245 (21%), Positives = 94/245 (38%), Gaps = 32/245 (13%) Query: 2 TEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRG 61 T GH V +A +P ILSA ++ I +W + E + ++ Sbjct: 105 LRTGTTYKRFVGHQSEVYSVAFSPDN-RQILSAGAEREIKLWNIL-GECKFSSAEK--EN 160 Query: 62 HSHFVSDVVISSD----------GQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSV 111 HS +VS V S + S WDG L++W+ T F H +V + Sbjct: 161 HSDWVSCVRYSPIMKSANKVQPFAPYFASVGWDGRLKVWN-TNFQIRYTFKAHESNVNHL 219 Query: 112 AFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWD 171 + S + + I +G +DK + +W+ L + + ++ ++ + F+P V+ G D Sbjct: 220 SISPNGKYIATGGKDKKLLIWDILNLTYPQREFDA-GSTINQIAFNP---KLQWVAVGTD 275 Query: 172 KLVKVWNLANC----------KLKTNHIGHTGY---LNTVTVSPDGSLCASGGKDGQAML 218 + VK++NL + T G G ++ + G +G DG Sbjct: 276 QGVKIFNLMTQSKAPVCTIEAEPITKAEGQKGKNPQCTSLAWNALGKKLFAGFTDGVIRT 335 Query: 219 WDLNE 223 + Sbjct: 336 FSFET 340 Score = 47.4 bits (111), Expect = 8e-06, Method: Composition-based stats. Identities = 11/70 (15%), Positives = 24/70 (34%), Gaps = 2/70 (2%) Query: 247 WLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNL 306 + + ++ IW L + + + + LA S + + D Sbjct: 42 LISGSRDKTVMIWKLYEEEQNGYF--GIPHKALTGHNHFVSDLALSQENCFAISSSWDKT 99 Query: 307 VRVWQVTIGT 316 +R+W + GT Sbjct: 100 LRLWDLRTGT 109 >5MZH-A nrPDB Length = 452 Score = 260 bits (663), Expect = 8e-70, Method: Composition-based stats. Identities = 78/310 (25%), Positives = 138/310 (44%), Gaps = 21/310 (6%) Query: 10 TLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDV 69 TL+GH V IA + D I++ S DKT +W + Y L+GH + + Sbjct: 131 TLEGHKNVVYAIAFNNPYGDKIVTGSFDKTCKLWDAYTGQLYY-----TLKGHQTEIVCL 185 Query: 70 VISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTI 129 + +GS D T +LWD+ TG GH +++S+ F++ IV+GS D Sbjct: 186 SFNPQSTIIATGSMDNTAKLWDVETGQERATLAGHRAEIVSLGFNTGGDLIVTGSFDHDS 245 Query: 130 KLWNTL-GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNH 188 +LW+ G C + + H VS +F N + ++VS D ++W++ + + + Sbjct: 246 RLWDVRTGQCVHVLS--GHRGEVSSTQF--NYAGTLVVSGSIDCTSRLWDVRSGRCLSVK 301 Query: 189 IGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGD-IINALCFSPNRY- 246 GHT + V G+ S DG A L+ G +TL G + I+ + F+P Sbjct: 302 QGHTDEVLDVAFDAAGTKMVSASADGSARLYHTLTGVCQHTLVGHEGEISKVAFNPQGTR 361 Query: 247 WLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNL 306 + A++ + ++WD + + L+ + S A++ +G + G DN Sbjct: 362 LITASSDKTCRLWDCDTGECLQVLE---------GHTDEIFSCAFNYEGDFIITGSKDNT 412 Query: 307 VRVWQVTIGT 316 R+W+ + Sbjct: 413 CRIWKALTAS 422 Score = 192 bits (489), Expect = 1e-49, Method: Composition-based stats. Identities = 60/308 (19%), Positives = 123/308 (39%), Gaps = 39/308 (12%) Query: 44 KLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVG 103 K+ + + + LR H +++ + G ++GS+D T ++W+ TG G Sbjct: 75 KMLEQQHHSFTLFKVLRAHILPLTNCAFNKSGDRFITGSYDRTCKVWNTFTGEEVFTLEG 134 Query: 104 HTKDVLSVAF-SSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSN 162 H V ++AF + +IV+GS DKT KLW+ + + H + C+ F+P S+ Sbjct: 135 HKNVVYAIAFNNPYGDKIVTGSFDKTCKLWDAY-TGQLYYTLKGHQTEIVCLSFNPQST- 192 Query: 163 PIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLN 222 II + D K+W++ + + GH + ++ + G L +G D + LWD+ Sbjct: 193 -IIATGSMDNTAKLWDVETGQERATLAGHRAEIVSLGFNTGGDLIVTGSFDHDSRLWDVR 251 Query: 223 EGKHLYTLDGG-DIINALCFSPNRYWLCAAT-GPSIKIWDLEGKIIVDELKQE------- 273 G+ ++ L G +++ F+ + + + + ++WD+ + + Sbjct: 252 TGQCVHVLSGHRGEVSSTQFNYAGTLVVSGSIDCTSRLWDVRSGRCLSVKQGHTDEVLDV 311 Query: 274 --------------------------VISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLV 307 V + + + +A++ G L +D Sbjct: 312 AFDAAGTKMVSASADGSARLYHTLTGVCQHTLVGHEGEISKVAFNPQGTRLITASSDKTC 371 Query: 308 RVWQVTIG 315 R+W G Sbjct: 372 RLWDCDTG 379 Score = 171 bits (433), Expect = 4e-43, Method: Composition-based stats. Identities = 62/219 (28%), Positives = 100/219 (45%), Gaps = 11/219 (5%) Query: 8 RGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVS 67 R TL GH + + D+I++ S D +W + G L GH VS Sbjct: 214 RATLAGHRAEIVSLGFN-TGGDLIVTGSFDHDSRLWDVRT-----GQCVHVLSGHRGEVS 267 Query: 68 DVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDK 127 + G +SGS D T RLWD+ +G GHT +VL VAF + ++VS S D Sbjct: 268 STQFNYAGTLVVSGSIDCTSRLWDVRSGRCLSVKQGHTDEVLDVAFDAAGTKMVSASADG 327 Query: 128 TIKLWNTL-GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKT 186 + +L++TL GVC++T+ H +S V F+P + +++ DK ++W+ + Sbjct: 328 SARLYHTLTGVCQHTL--VGHEGEISKVAFNPQGTR--LITASSDKTCRLWDCDTGECLQ 383 Query: 187 NHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGK 225 GHT + + + +G +G KD +W Sbjct: 384 VLEGHTDEIFSCAFNYEGDFIITGSKDNTCRIWKALTAS 422 Score = 40.8 bits (94), Expect = 8e-04, Method: Composition-based stats. Identities = 11/55 (20%), Positives = 20/55 (36%) Query: 261 LEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIG 315 L K++ + + +A T+ A++ G G D +VW G Sbjct: 72 LIDKMLEQQHHSFTLFKVLRAHILPLTNCAFNKSGDRFITGSYDRTCKVWNTFTG 126 >1VYH-C nrPDB Length = 410 Score = 258 bits (658), Expect = 3e-69, Method: Composition-based stats. Identities = 96/326 (29%), Positives = 140/326 (42%), Gaps = 42/326 (12%) Query: 11 LKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVV 70 L GH VT++ P F +++SAS D TI +W G +R L+GH+ V D+ Sbjct: 104 LSGHRSPVTRVIFHPVFS-VMVSASEDATIKVWDY-----ETGDFERTLKGHTDSVQDIS 157 Query: 71 ISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIK 130 G+ S S D T++LWD R GH +V SV+ + IVS SRDKTIK Sbjct: 158 FDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVSIMPNGDHIVSASRDKTIK 217 Query: 131 LWNT-LGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHI 189 +W G C T H EWV VR PN +I SC D+ V+VW +A + K Sbjct: 218 MWEVQTGYCVKTFT--GHREWVRMVR--PNQDGTLIASCSNDQTVRVWVVATKECKAELR 273 Query: 190 GHTGYLNTVTVSPD--------------------GSLCASGGKDGQAMLWDLNEGKHLYT 229 H + ++ +P+ G SG +D +WD++ G L T Sbjct: 274 EHRHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMT 333 Query: 230 LDGGD-IINALCFSPNR-YWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCT 287 L G D + + F + L A ++++WD + K + L A T Sbjct: 334 LVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTL---------NAHEHFVT 384 Query: 288 SLAWSADGQTLFAGYTDNLVRVWQVT 313 SL + + G D V+VW+ Sbjct: 385 SLDFHKTAPYVVTGSVDQTVKVWECR 410 Score = 208 bits (530), Expect = 2e-54, Method: Composition-based stats. Identities = 69/280 (24%), Positives = 118/280 (42%), Gaps = 27/280 (9%) Query: 3 EQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGH 62 E TLKGH V I+ ++ S S D TI +W E R + GH Sbjct: 138 ETGDFERTLKGHTDSVQDISFDH-SGKLLASCSADMTIKLWDFQGFE-----CIRTMHGH 191 Query: 63 SHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVS 122 H VS V I +G +S S D T+++W++ TG + F GH + V V + D I S Sbjct: 192 DHNVSSVSIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIAS 251 Query: 123 GSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSS------------------NPI 164 S D+T+++W + + + H V C+ ++P SS P Sbjct: 252 CSNDQTVRVW-VVATKECKAELREHRHVVECISWAPESSYSSISEATGSETKKSGKPGPF 310 Query: 165 IVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEG 224 ++S DK +K+W+++ +GH ++ V G S D +WD Sbjct: 311 LLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNK 370 Query: 225 KHLYTLDGGD-IINALCFSPNRYWLCAAT-GPSIKIWDLE 262 + + TL+ + + +L F ++ + ++K+W+ Sbjct: 371 RCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410 Score = 35.1 bits (79), Expect = 0.047, Method: Composition-based stats. Identities = 5/47 (10%), Positives = 14/47 (29%) Query: 270 LKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGT 316 + + + T + + + + D ++VW G Sbjct: 95 IPRPPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGD 141 >5XYI-g nrPDB Length = 335 Score = 253 bits (646), Expect = 7e-68, Method: Composition-based stats. Identities = 115/314 (36%), Positives = 165/314 (52%), Gaps = 4/314 (1%) Query: 5 MTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSH 64 R T GHN + I + + ++SASRDK+ ++WKL R + + P L GH+H Sbjct: 23 FAPRATFVGHNAAIESIEIDNEH-NYLVSASRDKSALVWKLNRTQEQWATPFTRLIGHNH 81 Query: 65 FVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGS 124 FVSDV +S D L+ SWD TLRLWDL+T TT + F+GH KDVL V FS NR+I+S Sbjct: 82 FVSDVSLSRDASHLLTSSWDSTLRLWDLSTRTTKKLFLGHKKDVLGVTFSPCNRRIISVG 141 Query: 125 RDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLA-NCK 183 RD +K+WN LG K +Q S V+C + +S +I WD V +W++ K Sbjct: 142 RDNQVKIWNILGENKAELQCSSWVTSVACAPMADETSPLVIAVGCWDGKVYIWSIEKEAK 201 Query: 184 LKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSP 243 L H G +V +PDG +GG D + ++W G + ++A+ P Sbjct: 202 LIKEFKAHDGRCTSVDFTPDGKWVITGGSDRKVVMWLTENGAKTISFTAPSPVHAVAACP 261 Query: 244 NRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSS--KAEPPQCTSLAWSADGQTLFAG 301 + W+CAAT I +WD+ K +D ++ P CT LAW+ADG L++G Sbjct: 262 TQAWICAATYEGIAVWDIGAKQQIDLVQPNFKHEGKRNAGRTPDCTCLAWAADGSVLYSG 321 Query: 302 YTDNLVRVWQVTIG 315 Y D +R W+V Sbjct: 322 YNDGSIRAWEVKSA 335 Score = 125 bits (314), Expect = 3e-29, Method: Composition-based stats. Identities = 53/229 (23%), Positives = 101/229 (44%), Gaps = 21/229 (9%) Query: 99 RRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCK----YTVQDESHSEWVSCV 154 FVGH + S+ +++ +VS SRDK+ +W + + H+ +VS V Sbjct: 27 ATFVGHNAAIESIEIDNEHNYLVSASRDKSALVWKLNRTQEQWATPFTRLIGHNHFVSDV 86 Query: 155 RFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDG 214 S ++S+ +++ WD +++W+L+ K +GH + VT SP S G+D Sbjct: 87 SLSRDASH--LLTSSWDSTLRLWDLSTRTTKKLFLGHKKDVLGVTFSPCNRRIISVGRDN 144 Query: 215 QAMLWDLNEGKHLYTLDGGDIINALCFSPNR------YWLCAATGPSIKIWDLEGKIIVD 268 Q +W++ G++ L + ++ +P + IW +E Sbjct: 145 QVKIWNIL-GENKAELQCSSWVTSVACAPMADETSPLVIAVGCWDGKVYIWSIE------ 197 Query: 269 ELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGTR 317 K+ + KA +CTS+ ++ DG+ + G +D V +W G + Sbjct: 198 --KEAKLIKEFKAHDGRCTSVDFTPDGKWVITGGSDRKVVMWLTENGAK 244 Score = 73.6 bits (179), Expect = 1e-13, Method: Composition-based stats. Identities = 19/140 (13%), Positives = 53/140 (37%), Gaps = 16/140 (11%) Query: 180 ANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLD------GG 233 A+ + +GH + ++ + + + S +D A++W LN + + Sbjct: 21 AHFAPRATFVGHNAAIESIEIDNEHNYLVSASRDKSALVWKLNRTQEQWATPFTRLIGHN 80 Query: 234 DIINALCFSPN-RYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWS 292 ++ + S + + L ++ ++++WDL + + +S Sbjct: 81 HFVSDVSLSRDASHLLTSSWDSTLRLWDLSTRTTKKLF---------LGHKKDVLGVTFS 131 Query: 293 ADGQTLFAGYTDNLVRVWQV 312 + + + DN V++W + Sbjct: 132 PCNRRIISVGRDNQVKIWNI 151 >5NNZ-B nrPDB Length = 415 Score = 250 bits (638), Expect = 7e-67, Method: Composition-based stats. Identities = 75/304 (24%), Positives = 132/304 (43%), Gaps = 19/304 (6%) Query: 10 TLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDV 69 TL+GH V IA + D I + S DKT +W + G RGH+ + + Sbjct: 129 TLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSV-----ETGKCYHTFRGHTAEIVCL 183 Query: 70 VISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTI 129 + +GS D T +LWD+ G GH+ +++S++F++ +I++GS D T+ Sbjct: 184 SFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTV 243 Query: 130 KLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHI 189 +W+ K + H +S F N +I++ DK K+W+ N K Sbjct: 244 VVWDADTGRKVNILI-GHCAEISSASF--NWDCSLILTGSMDKTCKLWDATNGKCVATLT 300 Query: 190 GHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGD-IINALCFSPNR-YW 247 GH + G L A+ DG A ++ K + L+G + I+ + F+P + Sbjct: 301 GHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHL 360 Query: 248 LCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLV 307 L ++ + +IWD + + L+ + S A++ G + G DN Sbjct: 361 LTGSSDKTARIWDAQTGQCLQVLE---------GHTDEIFSCAFNYKGNIVITGSKDNTC 411 Query: 308 RVWQ 311 R+W+ Sbjct: 412 RIWR 415 Score = 230 bits (587), Expect = 5e-61, Method: Composition-based stats. Identities = 76/315 (24%), Positives = 132/315 (41%), Gaps = 21/315 (6%) Query: 4 QMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHS 63 L LK H +T +A ++ S D+T +W E L GH Sbjct: 81 TFYLFKVLKAHILPLTNVALNKS-GSCFITGSYDRTCKLWDTASGEE-----LNTLEGHR 134 Query: 64 HFVSDVVIS-SDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVS 122 + V + + G +GS+D T +LW + TG F GHT +++ ++F+ + + + Sbjct: 135 NVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVAT 194 Query: 123 GSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANC 182 GS D T KLW+ + HS + + S N+S I++ +D V VW+ Sbjct: 195 GSMDTTAKLWDIQN-GEEVYTLRGHSAEI--ISLSFNTSGDRIITGSFDHTVVVWDADTG 251 Query: 183 KLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGD-IINALCF 241 + IGH +++ + + D SL +G D LWD GK + TL G D I CF Sbjct: 252 RKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCF 311 Query: 242 SPNRYWLCAAT-GPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFA 300 + A+ + +I+ + + +L+ + + ++++ G L Sbjct: 312 DYTGKLIATASADGTARIFSAATRKCIAKLE---------GHEGEISKISFNPQGNHLLT 362 Query: 301 GYTDNLVRVWQVTIG 315 G +D R+W G Sbjct: 363 GSSDKTARIWDAQTG 377 Score = 218 bits (555), Expect = 3e-57, Method: Composition-based stats. Identities = 69/260 (26%), Positives = 122/260 (46%), Gaps = 13/260 (5%) Query: 3 EQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGH 62 E T +GH + ++ PQ ++ + S D T +W + E Y LRGH Sbjct: 165 ETGKCYHTFRGHTAEIVCLSFNPQ-STLVATGSMDTTAKLWDIQNGEEVY-----TLRGH 218 Query: 63 SHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVS 122 S + + ++ G ++GS+D T+ +WD TG +GH ++ S +F+ D I++ Sbjct: 219 SAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILT 278 Query: 123 GSRDKTIKLWN-TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLAN 181 GS DKT KLW+ T G C T+ H + + F + + +I + D ++++ A Sbjct: 279 GSMDKTCKLWDATNGKCVATLT--GHDDEILDSCF--DYTGKLIATASADGTARIFSAAT 334 Query: 182 CKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGG-DIINALC 240 K GH G ++ ++ +P G+ +G D A +WD G+ L L+G D I + Sbjct: 335 RKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCA 394 Query: 241 FSPNRYWLCAAT-GPSIKIW 259 F+ + + + +IW Sbjct: 395 FNYKGNIVITGSKDNTCRIW 414 Score = 159 bits (401), Expect = 2e-39, Method: Composition-based stats. Identities = 53/220 (24%), Positives = 96/220 (43%), Gaps = 13/220 (5%) Query: 99 RRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSP 158 + H + +VA + ++GS D+T KLW+T + E H V + F+ Sbjct: 86 KVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDT-ASGEELNTLEGHRNVVYAIAFN- 143 Query: 159 NSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAML 218 N I + +DK K+W++ K GHT + ++ +P +L A+G D A L Sbjct: 144 NPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKL 203 Query: 219 WDLNEGKHLYTLDGGD-IINALCFSPNR-YWLCAATGPSIKIWDLEGKIIVDELKQEVIS 276 WD+ G+ +YTL G I +L F+ + + + ++ +WD + V+ L Sbjct: 204 WDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNIL------ 257 Query: 277 TSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGT 316 + +S +++ D + G D ++W T G Sbjct: 258 ---IGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGK 294 Score = 130 bits (327), Expect = 7e-31, Method: Composition-based stats. Identities = 39/175 (22%), Positives = 71/175 (40%), Gaps = 14/175 (8%) Query: 146 SHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVS-PDG 204 +H ++ V N S ++ +D+ K+W+ A+ + GH + + + P G Sbjct: 90 AHILPLTNVAL--NKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYG 147 Query: 205 SLCASGGKDGQAMLWDLNEGKHLYTLDGGD-IINALCFSPNRYWLCAAT-GPSIKIWDLE 262 A+G D LW + GK +T G I L F+P + + + K+WD++ Sbjct: 148 DKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQ 207 Query: 263 GKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGTR 317 V L+ + SL+++ G + G D+ V VW G + Sbjct: 208 NGEEVYTLR---------GHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRK 253 >5M25-A nrPDB Length = 434 Score = 237 bits (604), Expect = 6e-63, Method: Composition-based stats. Identities = 85/317 (26%), Positives = 145/317 (45%), Gaps = 28/317 (8%) Query: 4 QMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHS 63 L+ TL GH V+ + +P + + S+S DK I +W G ++ + GH Sbjct: 134 NYALKFTLAGHTKAVSSVKFSP-NGEWLASSSADKLIKIWGAYD-----GKFEKTISGHK 187 Query: 64 HFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSG 123 +SDV SSD +S S D TL++WD+++G + GH+ V F+ + IVSG Sbjct: 188 LGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSG 247 Query: 124 SRDKTIKLWNT-LGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANC 182 S D+++++W+ G C T+ +HS+ VS V F N +IVS +D L ++W+ A+ Sbjct: 248 SFDESVRIWDVKTGKCLKTLP--AHSDPVSAVHF--NRDGSLIVSSSYDGLCRIWDTASG 303 Query: 183 KLKTNHIGHTG-YLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCF 241 + I ++ V SP+G + D LWD ++GK L T G F Sbjct: 304 QCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIF 363 Query: 242 SP----NRYWLCAATGPS-IKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQ 296 + W+ + + + + IW+L+ K IV +L+ S A Sbjct: 364 ANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQ---------GHTDVVISTACHPTEN 414 Query: 297 TLFAGY--TDNLVRVWQ 311 + + D +++W+ Sbjct: 415 IIASAALENDKTIKLWK 431 Score = 234 bits (596), Expect = 4e-62, Method: Composition-based stats. Identities = 80/265 (30%), Positives = 126/265 (47%), Gaps = 16/265 (6%) Query: 55 PQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFS 114 + L GH+ VS V S +G++ S S D +++W G + GH + VA+S Sbjct: 137 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS 196 Query: 115 SDNRQIVSGSRDKTIKLWNTL-GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKL 173 SD+ +VS S DKT+K+W+ G C T++ HS +V C F+P S +IVS +D+ Sbjct: 197 SDSNLLVSASDDKTLKIWDVSSGKCLKTLK--GHSNYVFCCNFNPQS--NLIVSGSFDES 252 Query: 174 VKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTL--D 231 V++W++ K H+ ++ V + DGSL S DG +WD G+ L TL D Sbjct: 253 VRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDD 312 Query: 232 GGDIINALCFSPNR-YWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLA 290 ++ + FSPN Y L A ++K+WD + C Sbjct: 313 DNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKN-------EKYCIFAN 365 Query: 291 WSADG-QTLFAGYTDNLVRVWQVTI 314 +S G + + +G DNLV +W + Sbjct: 366 FSVTGGKWIVSGSEDNLVYIWNLQT 390 Score = 179 bits (453), Expect = 2e-45, Method: Composition-based stats. Identities = 59/219 (26%), Positives = 102/219 (46%), Gaps = 13/219 (5%) Query: 100 RFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPN 159 GHTK V SV FS + + S S DK IK+W K+ H +S V +S Sbjct: 140 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYD-GKFEKTISGHKLGISDVAWS-- 196 Query: 160 SSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLW 219 S + ++VS DK +K+W++++ K GH+ Y+ +P +L SG D +W Sbjct: 197 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 256 Query: 220 DLNEGKHLYTLDGG-DIINALCFSPNRYWLCAAT-GPSIKIWDLEGKIIVDELKQEVIST 277 D+ GK L TL D ++A+ F+ + + +++ +IWD + L Sbjct: 257 DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL------- 309 Query: 278 SSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGT 316 + P + + +S +G+ + A DN +++W + G Sbjct: 310 -IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGK 347 Score = 141 bits (355), Expect = 4e-34, Method: Composition-based stats. Identities = 46/176 (26%), Positives = 78/176 (44%), Gaps = 13/176 (7%) Query: 142 VQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVS 201 H++ VS V+FSPN + S DKL+K+W + K + GH ++ V S Sbjct: 139 FTLAGHTKAVSSVKFSPNGE--WLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS 196 Query: 202 PDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDI-INALCFSPNRYWLCAAT-GPSIKIW 259 D +L S D +WD++ GK L TL G + F+P + + + S++IW Sbjct: 197 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 256 Query: 260 DLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIG 315 D++ + L A +++ ++ DG + + D L R+W G Sbjct: 257 DVKTGKCLKTLP---------AHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASG 303 Score = 109 bits (273), Expect = 1e-24, Method: Composition-based stats. Identities = 35/139 (25%), Positives = 57/139 (41%), Gaps = 11/139 (7%) Query: 180 ANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGD-IINA 238 N LK GHT +++V SP+G AS D +W +GK T+ G I+ Sbjct: 133 PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISD 192 Query: 239 LCFSPNRYWLCAATGP-SIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQT 297 + +S + L +A+ ++KIWD+ + LK ++ Sbjct: 193 VAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLK---------GHSNYVFCCNFNPQSNL 243 Query: 298 LFAGYTDNLVRVWQVTIGT 316 + +G D VR+W V G Sbjct: 244 IVSGSFDESVRIWDVKTGK 262 >5FL8-q nrPDB Length = 515 Score = 231 bits (590), Expect = 3e-61, Method: Composition-based stats. Identities = 83/355 (23%), Positives = 144/355 (40%), Gaps = 62/355 (17%) Query: 3 EQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGH 62 + T TLKGH WV ++ +P ++I + S D TI +W + ALRGH Sbjct: 174 DTQTPMHTLKGHYNWVLCVSWSPD-GEVIATGSMDNTIRLWDPKSGQC----LGDALRGH 228 Query: 63 SHFVSDVVISS-------DGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSS 115 S +++ + S S DGT+++WD + GHT V V + Sbjct: 229 SKWITSLSWEPIHLVKPGSKPRLASSSKDGTIKIWDTVSRVCQYTMSGHTNSVSCVKWGG 288 Query: 116 DNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPN---------------- 159 + SGS D+T+++W+ + +SH+ WV+ + S + Sbjct: 289 QG-LLYSGSHDRTVRVWDINSQGRCINILKSHAHWVNHLSLSTDYALRIGAFDHTGKKPS 347 Query: 160 ---------------------SSNPIIVSCGWDKLVKVWN-LANCKLKTNHIGHTGYLNT 197 +S ++V+ D + +WN L + K GH +N Sbjct: 348 TPEEAQKKALENYEKICKKNGNSEEMMVTASDDYTMFLWNPLKSTKPIARMTGHQKLVNH 407 Query: 198 VTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGD-IINALCFSPN-RYWLCAATGPS 255 V SPDG S D LWD +GK + T G + + +S + R + + + Sbjct: 408 VAFSPDGRYIVSASFDNSIKLWDGRDGKFISTFRGHVASVYQVAWSSDCRLLVSCSKDTT 467 Query: 256 IKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVW 310 +K+WD+ + + +L + ++ WS DG+ + +G D +VR+W Sbjct: 468 LKVWDVRTRKLSVDLP---------GHKDEVYTVDWSVDGKRVCSGGKDKMVRLW 513 Score = 204 bits (518), Expect = 6e-53, Method: Composition-based stats. Identities = 81/356 (22%), Positives = 144/356 (40%), Gaps = 71/356 (19%) Query: 11 LKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVV 70 + GH + A P +++ + D T +W + P L+GH ++V V Sbjct: 139 IAGHGSTILCSAFAPHTSSRMVTGAGDNTARIWD-----CDTQTPMHTLKGHYNWVLCVS 193 Query: 71 ISSDGQFALSGSWDGTLRLWDLTTGTTTR-RFVGHTKDVLSVAFSS-------DNRQIVS 122 S DG+ +GS D T+RLWD +G GH+K + S+++ ++ S Sbjct: 194 WSPDGEVIATGSMDNTIRLWDPKSGQCLGDALRGHSKWITSLSWEPIHLVKPGSKPRLAS 253 Query: 123 GSRDKTIKLWNTLGV-CKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLAN 181 S+D TIK+W+T+ C+YT+ H+ VSCV++ ++ S D+ V+VW++ + Sbjct: 254 SSKDGTIKIWDTVSRVCQYTMS--GHTNSVSCVKW---GGQGLLYSGSHDRTVRVWDINS 308 Query: 182 -CKLKTNHIGHTGYLNTVTVSPD------------------------------------- 203 + H ++N +++S D Sbjct: 309 QGRCINILKSHAHWVNHLSLSTDYALRIGAFDHTGKKPSTPEEAQKKALENYEKICKKNG 368 Query: 204 --GSLCASGGKDGQAMLWD-LNEGKHLYTLDGGDI-INALCFSPN-RYWLCAATGPSIKI 258 + + D LW+ L K + + G +N + FSP+ RY + A+ SIK+ Sbjct: 369 NSEEMMVTASDDYTMFLWNPLKSTKPIARMTGHQKLVNHVAFSPDGRYIVSASFDNSIKL 428 Query: 259 WDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTI 314 WD + + +AWS+D + L + D ++VW V Sbjct: 429 WDGRDGKFISTFR---------GHVASVYQVAWSSDCRLLVSCSKDTTLKVWDVRT 475 Score = 174 bits (442), Expect = 4e-44, Method: Composition-based stats. Identities = 65/310 (20%), Positives = 109/310 (35%), Gaps = 57/310 (18%) Query: 55 PQRALRGHSHFVSDVVISSD-GQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAF 113 A+ GH + + ++G+ D T R+WD T T GH VL V++ Sbjct: 135 SSSAIAGHGSTILCSAFAPHTSSRMVTGAGDNTARIWDCDTQTPMHTLKGHYNWVLCVSW 194 Query: 114 SSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPN-----SSNPIIVSC 168 S D I +GS D TI+LW+ HS+W++ + + P S P + S Sbjct: 195 SPDGEVIATGSMDNTIRLWDPKSGQCLGDALRGHSKWITSLSWEPIHLVKPGSKPRLASS 254 Query: 169 GWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNE-GKHL 227 D +K+W+ + + GHT ++ V G L SG D +WD+N G+ + Sbjct: 255 SKDGTIKIWDTVSRVCQYTMSGHTNSVSCVKWGGQG-LLYSGSHDRTVRVWDINSQGRCI 313 Query: 228 YTLDGG-DIINALCFS----------------------------------------PNRY 246 L +N L S Sbjct: 314 NILKSHAHWVNHLSLSTDYALRIGAFDHTGKKPSTPEEAQKKALENYEKICKKNGNSEEM 373 Query: 247 WLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNL 306 + A+ ++ +W+ LK +A+S DG+ + + DN Sbjct: 374 MVTASDDYTMFLWN--------PLKSTKPIARMTGHQKLVNHVAFSPDGRYIVSASFDNS 425 Query: 307 VRVWQVTIGT 316 +++W G Sbjct: 426 IKLWDGRDGK 435 Score = 125 bits (315), Expect = 2e-29, Method: Composition-based stats. Identities = 44/197 (22%), Positives = 77/197 (39%), Gaps = 21/197 (10%) Query: 131 LWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIG 190 ++ V + + H + C F+P++S+ + V+ D ++W+ G Sbjct: 126 VFKVKPVTRSSSAIAGHGSTILCSAFAPHTSSRM-VTGAGDNTARIWDCDTQTPMHTLKG 184 Query: 191 HTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLY-TLDGGD-IINALCFSP----- 243 H ++ V+ SPDG + A+G D LWD G+ L L G I +L + P Sbjct: 185 HYNWVLCVSWSPDGEVIATGSMDNTIRLWDPKSGQCLGDALRGHSKWITSLSWEPIHLVK 244 Query: 244 ---NRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFA 300 ++ +IKIWD ++ + + + W G L++ Sbjct: 245 PGSKPRLASSSKDGTIKIWDTVSRVC---------QYTMSGHTNSVSCVKWGGQG-LLYS 294 Query: 301 GYTDNLVRVWQVTIGTR 317 G D VRVW + R Sbjct: 295 GSHDRTVRVWDINSQGR 311 >6HQA-B nrPDB Length = 722 Score = 230 bits (586), Expect = 7e-61, Method: Composition-based stats. Identities = 78/285 (27%), Positives = 126/285 (44%), Gaps = 23/285 (8%) Query: 15 NGWVTQIATTPQFPDMILSASRDKTIIMWKL-------------TRDETNYGIPQ---RA 58 N +T + M+ S +D I +W + + N G+ R Sbjct: 390 NNDLTCLKFN-DDSTMVASGFQDSFIKLWSIDGSPLRSLLKNDPYNQQNNDGVAVKGSRR 448 Query: 59 LRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNR 118 L GHS V V S D ++ +S S D T+RLW L T T + GH+ V V FS Sbjct: 449 LVGHSGAVYGVDFSPDNRYLISCSEDKTVRLWSLDTYTCLVSYKGHSSSVWDVKFSPMGH 508 Query: 119 QIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWN 178 + S D+T +LW+ + + H V CV F PNS+ + + DK ++W+ Sbjct: 509 YFATASHDQTARLWSCDHIYPLRI-FAGHLNDVDCVEFHPNST--YLFTGSSDKTARMWD 565 Query: 179 LANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGG--DII 236 +A + +GH+G +N + VSPDG AS G+D LWD++ G+ + + G I Sbjct: 566 IARGECVRVFMGHSGAINCLAVSPDGRWLASAGEDSVVCLWDISTGRRIKAMRGHGRSSI 625 Query: 237 NALCFSPNRY-WLCAATGPSIKIWDLEGKIIVDELKQEVISTSSK 280 +L FS + S+++WD++ + E I+ + Sbjct: 626 YSLAFSREGTVLVSTGADNSVRVWDVKKNTNSPSAQPEPINDVTA 670 Score = 195 bits (495), Expect = 2e-50, Method: Composition-based stats. Identities = 73/304 (24%), Positives = 121/304 (39%), Gaps = 34/304 (11%) Query: 36 RDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTG 95 +D + + + ++ ++ + + D SG D ++LW + Sbjct: 363 QDSRAKIKLSAAQASLPSVCMYTFHNTNNDLTCLKFNDDSTMVASGFQDSFIKLWSIDGS 422 Query: 96 ---------------------TTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNT 134 +RR VGH+ V V FS DNR ++S S DKT++LW + Sbjct: 423 PLRSLLKNDPYNQQNNDGVAVKGSRRLVGHSGAVYGVDFSPDNRYLISCSEDKTVRLW-S 481 Query: 135 LGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGY 194 L V + HS V V+FSP + D+ ++W+ + GH Sbjct: 482 LDTYTCLVSYKGHSSSVWDVKFSPMGH--YFATASHDQTARLWSCDHIYPLRIFAGHLND 539 Query: 195 LNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDI-INALCFSPNRYWLCAATG 253 ++ V P+ + +G D A +WD+ G+ + G IN L SP+ WL +A Sbjct: 540 VDCVEFHPNSTYLFTGSSDKTARMWDIARGECVRVFMGHSGAINCLAVSPDGRWLASAGE 599 Query: 254 PSI-KIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQV 312 S+ +WD+ + ++ SLA+S +G L + DN VRVW V Sbjct: 600 DSVVCLWDISTGRRIKAMRGH--------GRSSIYSLAFSREGTVLVSTGADNSVRVWDV 651 Query: 313 TIGT 316 T Sbjct: 652 KKNT 655 Score = 192 bits (487), Expect = 2e-49, Method: Composition-based stats. Identities = 64/234 (27%), Positives = 107/234 (45%), Gaps = 13/234 (5%) Query: 9 GTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSD 68 L GH+G V + +P ++S S DKT+ +W L + + +GHS V D Sbjct: 447 RRLVGHSGAVYGVDFSPDN-RYLISCSEDKTVRLWSL-----DTYTCLVSYKGHSSSVWD 500 Query: 69 VVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKT 128 V S G + + S D T RLW R F GH DV V F ++ + +GS DKT Sbjct: 501 VKFSPMGHYFATASHDQTARLWSCDHIYPLRIFAGHLNDVDCVEFHPNSTYLFTGSSDKT 560 Query: 129 IKLWNT-LGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTN 187 ++W+ G C HS ++C+ SP+ + S G D +V +W+++ + Sbjct: 561 ARMWDIARGECVRVFM--GHSGAINCLAVSPDGR--WLASAGEDSVVCLWDISTGRRIKA 616 Query: 188 HIGH-TGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALC 240 GH + ++ S +G++ S G D +WD+ + + + + IN + Sbjct: 617 MRGHGRSSIYSLAFSREGTVLVSTGADNSVRVWDVKKNTNSPSAQ-PEPINDVT 669 Score = 173 bits (438), Expect = 1e-43, Method: Composition-based stats. Identities = 58/243 (23%), Positives = 97/243 (39%), Gaps = 33/243 (13%) Query: 97 TTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTV-------------- 142 F D+ + F+ D+ + SG +D IKLW+ G ++ Sbjct: 382 CMYTFHNTNNDLTCLKFNDDSTMVASGFQDSFIKLWSIDGSPLRSLLKNDPYNQQNNDGV 441 Query: 143 ------QDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLN 196 + HS V V FSP+ N ++SC DK V++W+L ++ GH+ + Sbjct: 442 AVKGSRRLVGHSGAVYGVDFSPD--NRYLISCSEDKTVRLWSLDTYTCLVSYKGHSSSVW 499 Query: 197 TVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGG-DIINALCFSPNR-YWLCAATGP 254 V SP G A+ D A LW + L G + ++ + F PN Y ++ Sbjct: 500 DVKFSPMGHYFATASHDQTARLWSCDHIYPLRIFAGHLNDVDCVEFHPNSTYLFTGSSDK 559 Query: 255 SIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTI 314 + ++WD+ V LA S DG+ L + D++V +W ++ Sbjct: 560 TARMWDIARGECVRVF---------MGHSGAINCLAVSPDGRWLASAGEDSVVCLWDIST 610 Query: 315 GTR 317 G R Sbjct: 611 GRR 613 Score = 151 bits (380), Expect = 6e-37, Method: Composition-based stats. Identities = 46/179 (25%), Positives = 77/179 (43%), Gaps = 8/179 (4%) Query: 2 TEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRG 61 + T + KGH+ V + +P +AS D+T +W ++ P R G Sbjct: 482 LDTYTCLVSYKGHSSSVWDVKFSPM-GHYFATASHDQTARLWS-----CDHIYPLRIFAG 535 Query: 62 HSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIV 121 H + V V + + +GS D T R+WD+ G R F+GH+ + +A S D R + Sbjct: 536 HLNDVDCVEFHPNSTYLFTGSSDKTARMWDIARGECVRVFMGHSGAINCLAVSPDGRWLA 595 Query: 122 SGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLA 180 S D + LW+ + H S + + ++VS G D V+VW++ Sbjct: 596 SAGEDSVVCLWDI-STGRRIKAMRGHGRS-SIYSLAFSREGTVLVSTGADNSVRVWDVK 652 >2H9P-A nrPDB Length = 329 Score = 228 bits (580), Expect = 4e-60, Method: Composition-based stats. Identities = 84/317 (26%), Positives = 144/317 (45%), Gaps = 28/317 (8%) Query: 4 QMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHS 63 L+ TL GH V+ + +P + + S+S DK I +W G ++ + GH Sbjct: 29 NYALKFTLAGHTKAVSSVKFSP-NGEWLASSSADKLIKIWGAYD-----GKFEKTISGHK 82 Query: 64 HFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSG 123 +SDV SSD +S S D TL++WD+++G + GH+ V F+ + IVSG Sbjct: 83 LGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSG 142 Query: 124 SRDKTIKLWNT-LGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANC 182 S D+++++W+ G C T+ +HS+ VS V F N +IVS +D L ++W+ A+ Sbjct: 143 SFDESVRIWDVKTGKCLKTLP--AHSDPVSAVHF--NRDGSLIVSSSYDGLCRIWDTASG 198 Query: 183 KLKTNHIGHTG-YLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCF 241 + I ++ V SP+G + D LWD ++GK L T G F Sbjct: 199 QCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIF 258 Query: 242 SP-----NRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQ 296 + ++ + + + IW+L+ K IV +L+ S A Sbjct: 259 ANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQ---------GHTDVVISTACHPTEN 309 Query: 297 TLFAGY--TDNLVRVWQ 311 + + D +++W+ Sbjct: 310 IIASAALENDKTIKLWK 326 Score = 225 bits (573), Expect = 2e-59, Method: Composition-based stats. Identities = 80/265 (30%), Positives = 126/265 (47%), Gaps = 16/265 (6%) Query: 55 PQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFS 114 + L GH+ VS V S +G++ S S D +++W G + GH + VA+S Sbjct: 32 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS 91 Query: 115 SDNRQIVSGSRDKTIKLWNTL-GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKL 173 SD+ +VS S DKT+K+W+ G C T++ HS +V C F+P S +IVS +D+ Sbjct: 92 SDSNLLVSASDDKTLKIWDVSSGKCLKTLK--GHSNYVFCCNFNPQS--NLIVSGSFDES 147 Query: 174 VKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTL--D 231 V++W++ K H+ ++ V + DGSL S DG +WD G+ L TL D Sbjct: 148 VRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDD 207 Query: 232 GGDIINALCFSPNR-YWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLA 290 ++ + FSPN Y L A ++K+WD + C Sbjct: 208 DNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKN-------EKYCIFAN 260 Query: 291 WSADG-QTLFAGYTDNLVRVWQVTI 314 +S G + + +G DNLV +W + Sbjct: 261 FSVTGGKWIVSGSEDNLVYIWNLQT 285 Score = 172 bits (435), Expect = 2e-43, Method: Composition-based stats. Identities = 59/219 (26%), Positives = 102/219 (46%), Gaps = 13/219 (5%) Query: 100 RFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPN 159 GHTK V SV FS + + S S DK IK+W K+ H +S V +S Sbjct: 35 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYD-GKFEKTISGHKLGISDVAWS-- 91 Query: 160 SSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLW 219 S + ++VS DK +K+W++++ K GH+ Y+ +P +L SG D +W Sbjct: 92 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 151 Query: 220 DLNEGKHLYTLDGG-DIINALCFSPNRYWLCAAT-GPSIKIWDLEGKIIVDELKQEVIST 277 D+ GK L TL D ++A+ F+ + + +++ +IWD + L Sbjct: 152 DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL------- 204 Query: 278 SSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGT 316 + P + + +S +G+ + A DN +++W + G Sbjct: 205 -IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGK 242 Score = 135 bits (341), Expect = 2e-32, Method: Composition-based stats. Identities = 46/176 (26%), Positives = 78/176 (44%), Gaps = 13/176 (7%) Query: 142 VQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVS 201 H++ VS V+FSPN + S DKL+K+W + K + GH ++ V S Sbjct: 34 FTLAGHTKAVSSVKFSPNGE--WLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS 91 Query: 202 PDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDI-INALCFSPNRYWLCAAT-GPSIKIW 259 D +L S D +WD++ GK L TL G + F+P + + + S++IW Sbjct: 92 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 151 Query: 260 DLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIG 315 D++ + L A +++ ++ DG + + D L R+W G Sbjct: 152 DVKTGKCLKTLP---------AHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASG 198 Score = 105 bits (263), Expect = 2e-23, Method: Composition-based stats. Identities = 35/139 (25%), Positives = 57/139 (41%), Gaps = 11/139 (7%) Query: 180 ANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGD-IINA 238 N LK GHT +++V SP+G AS D +W +GK T+ G I+ Sbjct: 28 PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISD 87 Query: 239 LCFSPNRYWLCAATGP-SIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQT 297 + +S + L +A+ ++KIWD+ + LK ++ Sbjct: 88 VAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLK---------GHSNYVFCCNFNPQSNL 138 Query: 298 LFAGYTDNLVRVWQVTIGT 316 + +G D VR+W V G Sbjct: 139 IVSGSFDESVRIWDVKTGK 157 >6ID0-T nrPDB Length = 514 Score = 223 bits (569), Expect = 7e-59, Method: Composition-based stats. Identities = 72/310 (23%), Positives = 122/310 (39%), Gaps = 12/310 (3%) Query: 6 TLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHF 65 L + GH GWV IA P ++ S D+TI +W L G + +L GH Sbjct: 195 KLYRVISGHLGWVRCIAVEP-GNQWFVTGSADRTIKIWDLAS-----GKLKLSLTGHIST 248 Query: 66 VSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSR 125 V V++S+ + S D ++ WDL R + GH V + +V+ SR Sbjct: 249 VRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSR 308 Query: 126 DKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLK 185 D T ++W+ H+ V+ VR ++ P I++ D +++W+L K + Sbjct: 309 DSTARIWDVRTKAS-VHTLSGHTNAVATVRC--QAAEPQIITGSHDTTIRLWDLVAGKTR 365 Query: 186 TNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGD-IINALCFSPN 244 H + V + P ASG D W +G + L G + IIN L + + Sbjct: 366 VTLTNHKKSVRAVVLHPRHYTFASGSPDN-IKQWKFPDGSFIQNLSGHNAIINTLTVNSD 424 Query: 245 RYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTD 304 + A ++ +WD + V S +E + A+ L D Sbjct: 425 GVLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSES-GIFACAFDQSESRLLTAEAD 483 Query: 305 NLVRVWQVTI 314 ++V++ Sbjct: 484 KTIKVYREDD 493 Score = 189 bits (479), Expect = 2e-48, Method: Composition-based stats. Identities = 60/265 (22%), Positives = 100/265 (37%), Gaps = 14/265 (5%) Query: 52 YGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSV 111 R + GH +V + + Q+ ++GS D T+++WDL +G GH V V Sbjct: 193 PWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGV 252 Query: 112 AFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWD 171 S+ + + S DK +K W+ K H V + P ++V+C D Sbjct: 253 IVSTRSPYLFSCGEDKQVKCWDLE-YNKVIRHYHGHLSAVYGLDLHPTID--VLVTCSRD 309 Query: 172 KLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTL- 230 ++W++ GHT + TV +G D LWDL GK TL Sbjct: 310 STARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLT 369 Query: 231 DGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLA 290 + + A+ P Y + + +IK W + L +L Sbjct: 370 NHKKSVRAVVLHPRHYTFASGSPDNIKQWKFPDGSFIQNL---------SGHNAIINTLT 420 Query: 291 WSADGQTLFAGYTDNLVRVWQVTIG 315 ++DG L +G + + +W G Sbjct: 421 VNSDG-VLVSGADNGTMHLWDWRTG 444 Score = 111 bits (278), Expect = 4e-25, Method: Composition-based stats. Identities = 44/182 (24%), Positives = 67/182 (36%), Gaps = 13/182 (7%) Query: 137 VCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLN 196 K H WV C+ P N V+ D+ +K+W+LA+ KLK + GH + Sbjct: 193 PWKLYRVISGHLGWVRCIAVEP--GNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVR 250 Query: 197 TVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGG-DIINALCFSPN-RYWLCAATGP 254 V VS S G+D Q WDL K + G + L P + + Sbjct: 251 GVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDS 310 Query: 255 SIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTI 314 + +IWD+ K V L ++ A + G D +R+W + Sbjct: 311 TARIWDVRTKASVHTL---------SGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVA 361 Query: 315 GT 316 G Sbjct: 362 GK 363 Score = 96.7 bits (239), Expect = 1e-20, Method: Composition-based stats. Identities = 44/184 (23%), Positives = 73/184 (39%), Gaps = 13/184 (7%) Query: 10 TLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDV 69 TL GH V + P I++ S D TI +W L G + L H V V Sbjct: 325 TLSGHTNAVATVRCQAAEP-QIITGSHDTTIRLWDLVA-----GKTRVTLTNHKKSVRAV 378 Query: 70 VISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTI 129 V+ SGS D ++ W G+ + GH + ++ +SD +VSG+ + T+ Sbjct: 379 VLHPRHYTFASGSPDN-IKQWKFPDGSFIQNLSGHNAIINTLTVNSDG-VLVSGADNGTM 436 Query: 130 KLWNTLGVCKY-----TVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKL 184 LW+ + VQ S + + S +++ DK +KV+ + Sbjct: 437 HLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESRLLTAEADKTIKVYREDDTAT 496 Query: 185 KTNH 188 + H Sbjct: 497 EETH 500 Score = 70.9 bits (172), Expect = 8e-13, Method: Composition-based stats. Identities = 41/161 (25%), Positives = 66/161 (40%), Gaps = 25/161 (15%) Query: 6 TLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHF 65 R TL H V + P+ S S D I WK G + L GH+ Sbjct: 363 KTRVTLTNHKKSVRAVVLHPRH-YTFASGSPDN-IKQWKFPD-----GSFIQNLSGHNAI 415 Query: 66 VSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGH--------TKDVLSVAFSSDN 117 ++ + ++SDG +SG+ +GT+ LWD TG +R + + AF Sbjct: 416 INTLTVNSDG-VLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSE 474 Query: 118 RQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSP 158 ++++ DKTIK++ T +E+H V + P Sbjct: 475 SRLLTAEADKTIKVY----REDDTATEETHP-----VSWKP 506 Score = 40.4 bits (93), Expect = 0.001, Method: Composition-based stats. Identities = 6/46 (13%), Positives = 12/46 (26%) Query: 271 KQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGT 316 + +A Q G D +++W + G Sbjct: 192 PPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGK 237 >6F3T-A nrPDB Length = 608 Score = 214 bits (546), Expect = 3e-56, Method: Composition-based stats. Identities = 76/282 (26%), Positives = 118/282 (41%), Gaps = 33/282 (11%) Query: 7 LRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRD------------------ 48 L + G +T + T +I D T+ +W +T Sbjct: 271 FYTFLNAYQG-LTAVDVT-DDSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKES 328 Query: 49 --------ETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRR 100 + + L GHS V S D + LS S DGT+RLW L T T Sbjct: 329 DDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVG 388 Query: 101 FVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNS 160 + GH V FS VSG D+ +LW T + H V+C RF PNS Sbjct: 389 YKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRI-FAGHLADVNCTRFHPNS 447 Query: 161 SNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWD 220 + + D+ V++W++ N GH G ++++T SP+G A+G DG+ +LWD Sbjct: 448 --NYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWD 505 Query: 221 LNEGKHLYTLDGG-DIINALCFSPNRYWLCAAT-GPSIKIWD 260 + G + L G D + +L FS + L + + ++++WD Sbjct: 506 IGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 547 Score = 156 bits (394), Expect = 1e-38, Method: Composition-based stats. Identities = 60/269 (22%), Positives = 99/269 (36%), Gaps = 25/269 (9%) Query: 49 ETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDV 108 + I ++ V ++ D G D T+R+W +T K + Sbjct: 264 DCLPSICFYTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSVT-----------PKKL 312 Query: 109 LSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSC 168 SV +SD I S D ++ + + + HS V FSP+ ++S Sbjct: 313 RSVKQASDLSLIDKESDDVLERIMDEKTASELKI-LYGHSGPVYGASFSPD--RNYLLSS 369 Query: 169 GWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLY 228 D V++W+L + GH + SP G SGG D A LW + + L Sbjct: 370 SEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLR 429 Query: 229 TLDGG-DIINALCFSPNRYWLCAAT-GPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQC 286 G +N F PN ++ + ++++WD+ V Sbjct: 430 IFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIF---------TGHKGPI 480 Query: 287 TSLAWSADGQTLFAGYTDNLVRVWQVTIG 315 SL +S +G+ L G TD V +W + G Sbjct: 481 HSLTFSPNGRFLATGATDGRVLLWDIGHG 509 Score = 154 bits (389), Expect = 5e-38, Method: Composition-based stats. Identities = 47/168 (27%), Positives = 77/168 (45%), Gaps = 9/168 (5%) Query: 12 KGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVI 71 KGHN V +P + +S D+ +W T++ P R GH V+ Sbjct: 390 KGHNYPVWDTQFSP-YGYYFVSGGHDRVARLWA-----TDHYQPLRIFAGHLADVNCTRF 443 Query: 72 SSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKL 131 + + +GS D T+RLWD+ G R F GH + S+ FS + R + +G+ D + L Sbjct: 444 HPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLL 503 Query: 132 WNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNL 179 W+ G + + H++ V +RFS I+ S D V++W+ Sbjct: 504 WDI-GHGLMVGELKGHTDTVCSLRFS--RDGEILASGSMDNTVRLWDA 548 Score = 131 bits (329), Expect = 5e-31, Method: Composition-based stats. Identities = 39/144 (27%), Positives = 63/144 (43%), Gaps = 6/144 (4%) Query: 2 TEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRG 61 T+ GH V P + + + S D+T+ +W + G R G Sbjct: 422 TDHYQPLRIFAGHLADVNCTRFHP-NSNYVATGSADRTVRLWDVLN-----GNCVRIFTG 475 Query: 62 HSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIV 121 H + + S +G+F +G+ DG + LWD+ G GHT V S+ FS D + Sbjct: 476 HKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILA 535 Query: 122 SGSRDKTIKLWNTLGVCKYTVQDE 145 SGS D T++LW+ + + D+ Sbjct: 536 SGSMDNTVRLWDAIKAFEDLETDD 559 >5Y88-O nrPDB Length = 451 Score = 210 bits (535), Expect = 6e-55, Method: Composition-based stats. Identities = 73/308 (23%), Positives = 116/308 (37%), Gaps = 12/308 (3%) Query: 6 TLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHF 65 L + GH GWV +A P + ++ S D T+ +W L G + L GH Sbjct: 130 KLSRVINGHLGWVRCVAIDPVDNEWFITGSNDTTMKVWDLAT-----GKLKTTLAGHVMT 184 Query: 66 VSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSR 125 V DV +S + S S D T++ WDL R + GH V +V+ I + R Sbjct: 185 VRDVAVSDRHPYLFSVSEDKTVKCWDLEKNQIIRDYYGHLSGVRTVSIHPTLDLIATAGR 244 Query: 126 DKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLK 185 D IKLW+ + + H ++ V+ +P P +VS D V++W++ K Sbjct: 245 DSVIKLWD-MRTRIPVITLVGHKGPINQVQCTPVD--PQVVSSSTDATVRLWDVVAGKTM 301 Query: 186 TNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG--GDIINALCFSP 243 H + + P AS D W L EG L + IIN L + Sbjct: 302 KVLTHHKRSVRATALHPKEFSVASACTD-DIRSWGLAEGSLLTNFESEKTGIINTLSINQ 360 Query: 244 NRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYT 303 + + +D + L + S + E + G L G Sbjct: 361 DDVLFAGGDNGVLSFYDYKSGHKYQSLATREMVGSLEGERS-VLCSTFDKTGLRLITGEA 419 Query: 304 DNLVRVWQ 311 D +++W+ Sbjct: 420 DKSIKIWK 427 Score = 178 bits (452), Expect = 2e-45, Method: Composition-based stats. Identities = 66/268 (24%), Positives = 108/268 (40%), Gaps = 14/268 (5%) Query: 52 YGIPQRALRGHSHFVSDVVISS-DGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLS 110 R + GH +V V I D ++ ++GS D T+++WDL TG GH V Sbjct: 128 PWKLSRVINGHLGWVRCVAIDPVDNEWFITGSNDTTMKVWDLATGKLKTTLAGHVMTVRD 187 Query: 111 VAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGW 170 VA S + + S S DKT+K W+ + H V V P +I + G Sbjct: 188 VAVSDRHPYLFSVSEDKTVKCWDLE-KNQIIRDYYGHLSGVRTVSIHPTLD--LIATAGR 244 Query: 171 DKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTL 230 D ++K+W++ +GH G +N V +P S D LWD+ GK + L Sbjct: 245 DSVIKLWDMRTRIPVITLVGHKGPINQVQCTPVDPQVVSSSTDATVRLWDVVAGKTMKVL 304 Query: 231 DGGD-IINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSL 289 + A P + + +A I+ W L ++ + E +L Sbjct: 305 THHKRSVRATALHPKEFSVASACTDDIRSWGLAEGSLLTNFESEKTGI--------INTL 356 Query: 290 AWSADGQTLFAGYTDNLVRVWQVTIGTR 317 + + D LFAG + ++ + G + Sbjct: 357 SINQD-DVLFAGGDNGVLSFYDYKSGHK 383 Score = 112 bits (279), Expect = 3e-25, Method: Composition-based stats. Identities = 45/183 (24%), Positives = 66/183 (36%), Gaps = 12/183 (6%) Query: 136 GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYL 195 K + H WV CV P N ++ D +KVW+LA KLKT GH + Sbjct: 127 APWKLSRVINGHLGWVRCVAIDP-VDNEWFITGSNDTTMKVWDLATGKLKTTLAGHVMTV 185 Query: 196 NTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGG-DIINALCFSPNRYWLCAAT-G 253 V VS S +D WDL + + + G + + P + A Sbjct: 186 RDVAVSDRHPYLFSVSEDKTVKCWDLEKNQIIRDYYGHLSGVRTVSIHPTLDLIATAGRD 245 Query: 254 PSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVT 313 IK+WD+ +I V L + + + + TD VR+W V Sbjct: 246 SVIKLWDMRTRIPVITL---------VGHKGPINQVQCTPVDPQVVSSSTDATVRLWDVV 296 Query: 314 IGT 316 G Sbjct: 297 AGK 299 Score = 108 bits (269), Expect = 4e-24, Method: Composition-based stats. Identities = 50/252 (19%), Positives = 94/252 (37%), Gaps = 26/252 (10%) Query: 2 TEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRG 61 E+ + GH V ++ P D+I +A RD I +W + IP L G Sbjct: 211 LEKNQIIRDYYGHLSGVRTVSIHPTL-DLIATAGRDSVIKLWDMRT-----RIPVITLVG 264 Query: 62 HSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIV 121 H ++ V + +S S D T+RLWD+ G T + H + V + A + Sbjct: 265 HKGPINQVQCTPVDPQVVSSSTDATVRLWDVVAGKTMKVLTHHKRSVRATALHPKEFSVA 324 Query: 122 SGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWN--- 178 S D I+ W T + + ++ + + + ++ + G + ++ ++ Sbjct: 325 SACTDD-IRSWGLAEGSLLTNFESEKTGIINTLSINQDD---VLFAGGDNGVLSFYDYKS 380 Query: 179 ------LANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG 232 LA ++ + G + T G +G D +W +E + G Sbjct: 381 GHKYQSLATREMVGSLEGERS-VLCSTFDKTGLRLITGEADKSIKIWKQDETATKESEPG 439 Query: 233 GDIINALCFSPN 244 L ++PN Sbjct: 440 ------LAWNPN 445 Score = 80.5 bits (197), Expect = 9e-16, Method: Composition-based stats. Identities = 29/141 (20%), Positives = 53/141 (37%), Gaps = 13/141 (9%) Query: 177 WNLANCKLKTNHIGHTGYLNTVTVSP-DGSLCASGGKDGQAMLWDLNEGKHLYTLDGG-D 234 W+ KL GH G++ V + P D +G D +WDL GK TL G Sbjct: 125 WHA-PWKLSRVINGHLGWVRCVAIDPVDNEWFITGSNDTTMKVWDLATGKLKTTLAGHVM 183 Query: 235 IINALCFSP-NRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSA 293 + + S + Y + ++K WDLE I+ + +++ Sbjct: 184 TVRDVAVSDRHPYLFSVSEDKTVKCWDLEKNQIIRDY---------YGHLSGVRTVSIHP 234 Query: 294 DGQTLFAGYTDNLVRVWQVTI 314 + D+++++W + Sbjct: 235 TLDLIATAGRDSVIKLWDMRT 255 >6MZM-G nrPDB Length = 800 Score = 210 bits (534), Expect = 6e-55, Method: Composition-based stats. Identities = 67/206 (32%), Positives = 101/206 (49%), Gaps = 5/206 (2%) Query: 57 RALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSD 116 + L GHS V S D + LS S DGT+RLW L T T + GH V FS Sbjct: 537 KILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPY 596 Query: 117 NRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKV 176 VSG D+ +LW T + H V+C RF PNS + + D+ V++ Sbjct: 597 GYYFVSGGHDRVARLWATDHYQPLRI-FAGHLADVNCTRFHPNS--NYVATGSADRTVRL 653 Query: 177 WNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGG-DI 235 W++ N GH G ++++T SP+G A+G DG+ +LWD+ G + L G D Sbjct: 654 WDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDT 713 Query: 236 INALCFSPNRYWLCAAT-GPSIKIWD 260 + +L FS + L + + ++++WD Sbjct: 714 VCSLRFSRDGEILASGSMDNTVRLWD 739 Score = 195 bits (495), Expect = 3e-50, Method: Composition-based stats. Identities = 61/210 (29%), Positives = 96/210 (45%), Gaps = 9/210 (4%) Query: 11 LKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVV 70 L GH+G V + +P + +LS+S D T+ +W L G +GH++ V D Sbjct: 539 LYGHSGPVYGASFSPDR-NYLLSSSEDGTVRLWSLQTFTCLVG-----YKGHNYPVWDTQ 592 Query: 71 ISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIK 130 S G + +SG D RLW R F GH DV F ++ + +GS D+T++ Sbjct: 593 FSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVR 652 Query: 131 LWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIG 190 LW+ L + H + + FSPN + + D V +W++ + + G Sbjct: 653 LWDVLNGNCVRIFT-GHKGPIHSLTFSPNGR--FLATGATDGRVLLWDIGHGLMVGELKG 709 Query: 191 HTGYLNTVTVSPDGSLCASGGKDGQAMLWD 220 HT + ++ S DG + ASG D LWD Sbjct: 710 HTDTVCSLRFSRDGEILASGSMDNTVRLWD 739 Score = 189 bits (480), Expect = 1e-48, Method: Composition-based stats. Identities = 63/220 (28%), Positives = 98/220 (44%), Gaps = 14/220 (6%) Query: 99 RRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSP 158 + GH+ V +FS D ++S S D T++LW +L V + H+ V +FSP Sbjct: 537 KILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLW-SLQTFTCLVGYKGHNYPVWDTQFSP 595 Query: 159 NSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAML 218 VS G D++ ++W + + GH +N P+ + A+G D L Sbjct: 596 YG--YYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRL 653 Query: 219 WDLNEGKHLYTLDGGD-IINALCFSPNRYWLC-AATGPSIKIWDLEGKIIVDELKQEVIS 276 WD+ G + G I++L FSPN +L AT + +WD+ ++V ELK Sbjct: 654 WDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELK----- 708 Query: 277 TSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGT 316 SL +S DG+ L +G DN VR+W Sbjct: 709 ----GHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAF 744 Score = 157 bits (398), Expect = 5e-39, Method: Composition-based stats. Identities = 47/168 (27%), Positives = 77/168 (45%), Gaps = 9/168 (5%) Query: 12 KGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVI 71 KGHN V +P + +S D+ +W T++ P R GH V+ Sbjct: 582 KGHNYPVWDTQFSP-YGYYFVSGGHDRVARLWA-----TDHYQPLRIFAGHLADVNCTRF 635 Query: 72 SSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKL 131 + + +GS D T+RLWD+ G R F GH + S+ FS + R + +G+ D + L Sbjct: 636 HPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLL 695 Query: 132 WNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNL 179 W+ G + + H++ V +RFS I+ S D V++W+ Sbjct: 696 WDI-GHGLMVGELKGHTDTVCSLRFS--RDGEILASGSMDNTVRLWDA 740 Score = 134 bits (336), Expect = 7e-32, Method: Composition-based stats. Identities = 39/144 (27%), Positives = 63/144 (43%), Gaps = 6/144 (4%) Query: 2 TEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRG 61 T+ GH V P + + + S D+T+ +W + G R G Sbjct: 614 TDHYQPLRIFAGHLADVNCTRFHP-NSNYVATGSADRTVRLWDVLN-----GNCVRIFTG 667 Query: 62 HSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIV 121 H + + S +G+F +G+ DG + LWD+ G GHT V S+ FS D + Sbjct: 668 HKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILA 727 Query: 122 SGSRDKTIKLWNTLGVCKYTVQDE 145 SGS D T++LW+ + + D+ Sbjct: 728 SGSMDNTVRLWDAIKAFEDLETDD 751 >6QX9-5O nrPDB Length = 357 Score = 205 bits (521), Expect = 2e-53, Method: Composition-based stats. Identities = 80/309 (25%), Positives = 132/309 (42%), Gaps = 29/309 (9%) Query: 11 LKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVV 70 L GH G V P + SA D+ I++W + D NY L+GHS V ++ Sbjct: 62 LSGHEGEVYCCKFHP-NGSTLASAGFDRLILLWNVYGDCDNYA----TLKGHSGAVMELH 116 Query: 71 ISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIV-SGSRDKTI 129 ++DG S S D T+ +WD TG +R GHT V S + Q+V +GS D T+ Sbjct: 117 YNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTV 176 Query: 130 KLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHI 189 KLW+ K +Q ++ V V F N ++ I+S G D +KVW+L KL Sbjct: 177 KLWDIR--KKAAIQTFQNTYQVLAVTF--NDTSDQIISGGIDNDIKVWDLRQNKLTYTMR 232 Query: 190 GHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLN----EGKHLYTLDGG-----DIINALC 240 GH + +++S +GS S D +WD+ + + + G + Sbjct: 233 GHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCS 292 Query: 241 FSPNRYWLCAAT-GPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLF 299 +SP+ + A + + +WD + I+ +L +A+ D + Sbjct: 293 WSPDGSKIAAGSADRFVYVWDTTSRRILYKLP---------GHAGSINEVAFHPDEPIII 343 Query: 300 AGYTDNLVR 308 + +D + Sbjct: 344 SASSDKRLY 352 Score = 199 bits (506), Expect = 1e-51, Method: Composition-based stats. Identities = 77/257 (29%), Positives = 119/257 (46%), Gaps = 20/257 (7%) Query: 8 RGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVS 67 TLKGH+G V ++ M+ SAS DKT+ +W E + L+GH+ FV+ Sbjct: 102 YATLKGHSGAVMELHYN-TDGSMLFSASTDKTVAVWDSETGER-----VKRLKGHTSFVN 155 Query: 68 DVVISSDGQFALS-GSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRD 126 + G + GS DGT++LWD+ + F T VL+V F+ + QI+SG D Sbjct: 156 SCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQN-TYQVLAVTFNDTSDQIISGGID 214 Query: 127 KTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANC---- 182 IK+W+ K T H++ V+ + S S ++S D V+VW++ Sbjct: 215 NDIKVWDLR-QNKLTYTMRGHADSVTGLSLS--SEGSYLLSNAMDNTVRVWDVRPFAPKE 271 Query: 183 KLKTNHIG--HTGYLNTV--TVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGG-DIIN 237 + G H N + + SPDGS A+G D +WD + LY L G IN Sbjct: 272 RCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSIN 331 Query: 238 ALCFSPNRYWLCAATGP 254 + F P+ + +A+ Sbjct: 332 EVAFHPDEPIIISASSD 348 Score = 175 bits (443), Expect = 3e-44, Method: Composition-based stats. Identities = 60/263 (22%), Positives = 105/263 (39%), Gaps = 7/263 (2%) Query: 55 PQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLT-TGTTTRRFVGHTKDVLSVAF 113 P L GH V +G S +D + LW++ GH+ V+ + + Sbjct: 58 PIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHY 117 Query: 114 SSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKL 173 ++D + S S DKT+ +W++ + + + H+ +V+ + ++ + D Sbjct: 118 NTDGSMLFSASTDKTVAVWDSE-TGERVKRLKGHTSFVNSC-YPARRGPQLVCTGSDDGT 175 Query: 174 VKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGG 233 VK+W++ T + VT + SGG D +WDL + K YT+ G Sbjct: 176 VKLWDIRKKAAIQTFQN-TYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGH 234 Query: 234 -DIINALCFSPNR-YWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAW 291 D + L S Y L A ++++WD+ E ++ + +W Sbjct: 235 ADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAP-KERCVKIFQGNVHNFEKNLLRCSW 293 Query: 292 SADGQTLFAGYTDNLVRVWQVTI 314 S DG + AG D V VW T Sbjct: 294 SPDGSKIAAGSADRFVYVWDTTS 316 Score = 158 bits (399), Expect = 3e-39, Method: Composition-based stats. Identities = 47/213 (22%), Positives = 89/213 (41%), Gaps = 11/213 (5%) Query: 11 LKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVV 70 LKGH +V + P ++ + S D T+ +W + + + + ++ V V Sbjct: 147 LKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKK-----AAIQTFQN-TYQVLAVT 200 Query: 71 ISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIK 130 + +SG D +++WDL T GH V ++ SS+ ++S + D T++ Sbjct: 201 FNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVR 260 Query: 131 LWNTL-----GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLK 185 +W+ C Q H+ + +R S + I + D+ V VW+ + ++ Sbjct: 261 VWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRIL 320 Query: 186 TNHIGHTGYLNTVTVSPDGSLCASGGKDGQAML 218 GH G +N V PD + S D + + Sbjct: 321 YKLPGHAGSINEVAFHPDEPIIISASSDKRLYM 353 Score = 118 bits (295), Expect = 4e-27, Method: Composition-based stats. Identities = 39/181 (21%), Positives = 73/181 (40%), Gaps = 16/181 (8%) Query: 140 YTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNL-ANCKLKTNHIGHTGYLNTV 198 + H V C +F PN S + S G+D+L+ +WN+ +C GH+G + + Sbjct: 58 PIMLLSGHEGEVYCCKFHPNGST--LASAGFDRLILLWNVYGDCDNYATLKGHSGAVMEL 115 Query: 199 TVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNR---YWLCAATGPS 255 + DGS+ S D +WD G+ + L G C+ R + + Sbjct: 116 HYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGT 175 Query: 256 IKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIG 315 +K+WD+ K + + Q ++ ++ + +G DN ++VW + Sbjct: 176 VKLWDIRKKAAIQTFQN----------TYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQN 225 Query: 316 T 316 Sbjct: 226 K 226 Score = 56.2 bits (134), Expect = 2e-08, Method: Composition-based stats. Identities = 23/94 (24%), Positives = 34/94 (36%), Gaps = 10/94 (10%) Query: 226 HLYTLDGGD-IINALCFSPNRYWLCAAT-GPSIKIWDLEGKIIVDELKQEVISTSSKAEP 283 + L G + + F PN L +A I +W++ G + K Sbjct: 58 PIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNY--------ATLKGHS 109 Query: 284 PQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGTR 317 L ++ DG LF+ TD V VW G R Sbjct: 110 GAVMELHYNTDGSMLFSASTDKTVAVWDSETGER 143 >6QX9-4B nrPDB Length = 522 Score = 201 bits (511), Expect = 3e-52, Method: Composition-based stats. Identities = 68/327 (20%), Positives = 118/327 (36%), Gaps = 35/327 (10%) Query: 1 MTEQMTLRGTLK------GHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGI 54 M E +L G + ++ +P M+ +A +W + Sbjct: 211 MQELHKSLRSLNNFCSQIGDDRPISYCHFSP-NSKMLATACWSGLCKLWSVPD-----CN 264 Query: 55 PQRALRGHSHFVSDVVISSDGQF--------ALSGSWDGTLRLWDLTTGTTTRRFVGHTK 106 LRGH+ V +V S + DG+++LW L + GHT Sbjct: 265 LLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTV 324 Query: 107 DVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIV 166 V V + R + + D++ +LW+ + + E HS V + F + Sbjct: 325 RVARVMWHPSGRFLGTTCYDRSWRLWDLEAQ-EEILHQEGHSMGVYDIAFH--QDGSLAG 381 Query: 167 SCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKH 226 + G D +VW+L + GH + + SP+G A+G D +WDL + + Sbjct: 382 TGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRC 441 Query: 227 LYTLDGGDI-INALCFSP--NRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEP 283 +YT+ + + F P + L A + KIW G + L Sbjct: 442 VYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTL---------AGHE 492 Query: 284 PQCTSLAWSADGQTLFAGYTDNLVRVW 310 + L S+DGQ + D ++W Sbjct: 493 GKVMGLDISSDGQLIATCSYDRTFKLW 519 Score = 131 bits (330), Expect = 3e-31, Method: Composition-based stats. Identities = 44/231 (19%), Positives = 83/231 (35%), Gaps = 18/231 (7%) Query: 91 DLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEW 150 L + +G + + FS +++ + + KLW+ C H+ Sbjct: 217 SLRSLNNFCSQIGDDRPISYCHFSPNSKMLATACWSGLCKLWSVPD-CNLLHTLRGHNTN 275 Query: 151 VSCVRFSPNSSNPI------IVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDG 204 V + F P S+ + + SC D VK+W+L + + + GHT + V P G Sbjct: 276 VGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSG 335 Query: 205 SLCASGGKDGQAMLWDLNEGKHLYTLDGGD-IINALCFSPNRYWL-CAATGPSIKIWDLE 262 + D LWDL + + +G + + F + ++WDL Sbjct: 336 RFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLR 395 Query: 263 GKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVT 313 + L+ + + +S +G + G DN +VW + Sbjct: 396 TGRCIMFLE---------GHLKEIYGINFSPNGYHIATGSGDNTCKVWDLR 437 Score = 105 bits (262), Expect = 2e-23, Method: Composition-based stats. Identities = 41/196 (20%), Positives = 73/196 (37%), Gaps = 21/196 (10%) Query: 131 LWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIG 190 L +L +S FSPNS ++ + W L K+W++ +C L G Sbjct: 214 LHKSLRSLNNFCSQIGDDRPISYCHFSPNS--KMLATACWSGLCKLWSVPDCNLLHTLRG 271 Query: 191 HTGYLNTVTVSPDGSL--------CASGGKDGQAMLWDLNEGKHLYTLDGGDI-INALCF 241 H + + P ++ AS DG LW L+ + + ++G + + + + Sbjct: 272 HNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMW 331 Query: 242 SPNRYWL-CAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFA 300 P+ +L S ++WDLE + + + +A+ DG Sbjct: 332 HPSGRFLGTTCYDRSWRLWDLEAQEEI---------LHQEGHSMGVYDIAFHQDGSLAGT 382 Query: 301 GYTDNLVRVWQVTIGT 316 G D RVW + G Sbjct: 383 GGLDAFGRVWDLRTGR 398 >6N9G-C nrPDB Length = 353 Score = 201 bits (511), Expect = 4e-52, Method: Composition-based stats. Identities = 73/316 (23%), Positives = 122/316 (38%), Gaps = 26/316 (8%) Query: 5 MTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSH 64 M R TLKGH V + I+S+S+D +I+W + + Sbjct: 53 MKTRRTLKGHGNKVLCMDWCKD-KRRIVSSSQDGKVIVWDSFTTNKEHAVTMPC-----T 106 Query: 65 FVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTT------RRFVGHTKDVLSVAFSSDNR 118 +V + G G D ++ LT + HT + + +F++ + Sbjct: 107 WVMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDM 166 Query: 119 QIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWN 178 QI++ S D T LW+ + H V C+ +P+ + VS G DK VW+ Sbjct: 167 QILTASGDGTCALWDVES-GQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWD 225 Query: 179 LANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDII-- 236 + + + H +N+V P G ASG D L+DL + + II Sbjct: 226 MRSGQCVQAFETHESDVNSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFG 285 Query: 237 -NALCFSPNRYWLCAAT-GPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSAD 294 +++ FS + L A +I +WD+ V L + ++L S D Sbjct: 286 ASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSIL---------FGHENRVSTLRVSPD 336 Query: 295 GQTLFAGYTDNLVRVW 310 G +G D+ +RVW Sbjct: 337 GTAFCSGSWDHTLRVW 352 Score = 184 bits (468), Expect = 4e-47, Method: Composition-based stats. Identities = 60/271 (22%), Positives = 119/271 (43%), Gaps = 18/271 (6%) Query: 56 QRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSS 115 +R L+GH + V + D + +S S DG + +WD T V++ A++ Sbjct: 56 RRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAP 115 Query: 116 DNRQIVSGSRDKTIKLW-----NTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGW 170 I G D ++ + H+ ++S F +S+ I++ Sbjct: 116 SGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSF--TNSDMQILTASG 173 Query: 171 DKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPD--GSLCASGGKDGQAMLWDLNEGKHLY 228 D +W++ + +L + GH + + ++P G+ SGG D +AM+WD+ G+ + Sbjct: 174 DGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQ 233 Query: 229 TLDGG-DIINALCFSPNR-YWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQC 286 + +N++ + P+ + + + +++DL +EV S ++ Sbjct: 234 AFETHESDVNSVRYYPSGDAFASGSDDATCRLYDLRA-------DREVAIYSKESIIFGA 286 Query: 287 TSLAWSADGQTLFAGYTDNLVRVWQVTIGTR 317 +S+ +S G+ LFAGY D + VW V G+R Sbjct: 287 SSVDFSLSGRLLFAGYNDYTINVWDVLKGSR 317 Score = 111 bits (277), Expect = 5e-25, Method: Composition-based stats. Identities = 47/178 (26%), Positives = 72/178 (40%), Gaps = 11/178 (6%) Query: 3 EQMTLRGTLKGHNGWVTQIATTP-QFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRG 61 E L + GH V + P + + +S DK ++W + G +A Sbjct: 183 ESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRS-----GQCVQAFET 237 Query: 62 HSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTK--DVLSVAFSSDNRQ 119 H V+ V G SGS D T RL+DL + + SV FS R Sbjct: 238 HESDVNSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRL 297 Query: 120 IVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVW 177 + +G D TI +W+ L + ++ H VS +R SP+ + S WD ++VW Sbjct: 298 LFAGYNDYTINVWDVLKGSRVSI-LFGHENRVSTLRVSPDGTA--FCSGSWDHTLRVW 352 >4V7E-Bg nrPDB Length = 380 Score = 198 bits (504), Expect = 2e-51, Method: Composition-based stats. Identities = 75/327 (22%), Positives = 140/327 (42%), Gaps = 34/327 (10%) Query: 9 GTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSD 68 TL+GH+G V + TP+ + I+SAS+D +I+W + A++ H +V + Sbjct: 60 RTLQGHSGKVYSLDWTPE-KNWIVSASQDGRLIVWNALTSQK-----THAIKLHCPWVME 113 Query: 69 VVISSDGQFALSGSWDGTLRLWDLTTGT-------TTRRFVGHTKDVLSVAFSSDNR-QI 120 + +GQ G D +++L++ +R GH S + D ++ Sbjct: 114 CAFAPNGQSVACGGLDSACSIFNLSSQADRDGNMPVSRVLTGHKGYASSCQYVPDQETRL 173 Query: 121 VSGSRDKTIKLWNTLGVCKYTVQ----DESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKV 176 ++GS D+T LW+ + ++ H+ V + + ++N + +S D V++ Sbjct: 174 ITGSGDQTCVLWDVTTGQRISIFGSEFPSGHTADVLSLSINSLNAN-MFISGSCDTTVRL 232 Query: 177 WNLA-NCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGD- 234 W+L + + GH G +N+V PDG +G DG L+D+ G L + Sbjct: 233 WDLRITSRAVRTYHGHEGDINSVKFFPDGQRFGTGSDDGTCRLFDMRTGHQLQVYNREPD 292 Query: 235 -------IINALCFSPNRYWLCAA-TGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQC 286 I+ ++ FS + L A + +WD +V L T + + Sbjct: 293 RNDNELPIVTSVAFSISGRLLFAGYSNGDCYVWDTLLAEMVLNL-----GTLQNSHEGRI 347 Query: 287 TSLAWSADGQTLFAGYTDNLVRVWQVT 313 + L S+DG L G D +++W + Sbjct: 348 SCLGLSSDGSALCTGSWDKNLKIWAFS 374 Score = 165 bits (418), Expect = 2e-41, Method: Composition-based stats. Identities = 60/274 (21%), Positives = 117/274 (42%), Gaps = 18/274 (6%) Query: 54 IPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAF 113 + R L+GHS V + + + + +S S DG L +W+ T T H V+ AF Sbjct: 57 VCCRTLQGHSGKVYSLDWTPEKNWIVSASQDGRLIVWNALTSQKTHAIKLHCPWVMECAF 116 Query: 114 SSDNRQIVSGSRDKTIKLWNTLGVCKY------TVQDESHSEWVSCVRFSPNSSNPIIVS 167 + + + + G D ++N + H + S ++ P+ +I + Sbjct: 117 APNGQSVACGGLDSACSIFNLSSQADRDGNMPVSRVLTGHKGYASSCQYVPDQETRLI-T 175 Query: 168 CGWDKLVKVWNLANCKLKTNH-----IGHTGYLNTVTV-SPDGSLCASGGKDGQAMLWDL 221 D+ +W++ + + GHT + ++++ S + ++ SG D LWDL Sbjct: 176 GSGDQTCVLWDVTTGQRISIFGSEFPSGHTADVLSLSINSLNANMFISGSCDTTVRLWDL 235 Query: 222 N-EGKHLYTLDGGD-IINALCFSPNRYWL-CAATGPSIKIWDLEGKIIVDELKQEVISTS 278 + + T G + IN++ F P+ + + +++D+ + +E Sbjct: 236 RITSRAVRTYHGHEGDINSVKFFPDGQRFGTGSDDGTCRLFDMRTGHQLQVYNREPDR-- 293 Query: 279 SKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQV 312 + E P TS+A+S G+ LFAGY++ VW Sbjct: 294 NDNELPIVTSVAFSISGRLLFAGYSNGDCYVWDT 327 Score = 131 bits (330), Expect = 3e-31, Method: Composition-based stats. Identities = 55/226 (24%), Positives = 100/226 (44%), Gaps = 10/226 (4%) Query: 4 QMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHS 63 M + L GH G+ + P +++ S D+T ++W +T + GH+ Sbjct: 146 NMPVSRVLTGHKGYASSCQYVPDQETRLITGSGDQTCVLWDVTTGQRISIFGSEFPSGHT 205 Query: 64 HFVSDVVISS-DGQFALSGSWDGTLRLWDLT-TGTTTRRFVGHTKDVLSVAFSSDNRQIV 121 V + I+S + +SGS D T+RLWDL T R + GH D+ SV F D ++ Sbjct: 206 ADVLSLSINSLNANMFISGSCDTTVRLWDLRITSRAVRTYHGHEGDINSVKFFPDGQRFG 265 Query: 122 SGSRDKTIKLWNTLGVCK---YTVQDESHSEWVSCV-RFSPNSSNPIIVSCGWDKLVKVW 177 +GS D T +L++ + Y + + + + V + + S ++ + + VW Sbjct: 266 TGSDDGTCRLFDMRTGHQLQVYNREPDRNDNELPIVTSVAFSISGRLLFAGYSNGDCYVW 325 Query: 178 NLANCKLKTNH----IGHTGYLNTVTVSPDGSLCASGGKDGQAMLW 219 + ++ N H G ++ + +S DGS +G D +W Sbjct: 326 DTLLAEMVLNLGTLQNSHEGRISCLGLSSDGSALCTGSWDKNLKIW 371 Score = 127 bits (318), Expect = 8e-30, Method: Composition-based stats. Identities = 52/237 (21%), Positives = 92/237 (38%), Gaps = 27/237 (11%) Query: 97 TTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRF 156 R GH+ V S+ ++ + IVS S+D + +WN L + T + H WV F Sbjct: 58 CCRTLQGHSGKVYSLDWTPEKNWIVSASQDGRLIVWNAL-TSQKTHAIKLHCPWVMECAF 116 Query: 157 SPNSSNPIIVSCGWDKLVKVWNLA-------NCKLKTNHIGHTGYLNTVTVSPD-GSLCA 208 +PN + + G D ++NL+ N + GH GY ++ PD + Sbjct: 117 APNGQS--VACGGLDSACSIFNLSSQADRDGNMPVSRVLTGHKGYASSCQYVPDQETRLI 174 Query: 209 SGGKDGQAMLWDLNEGKHLYTL----DGGDIINALCFSPNR----YWLCAATGPSIKIWD 260 +G D +LWD+ G+ + G + L S N ++ + ++++WD Sbjct: 175 TGSGDQTCVLWDVTTGQRISIFGSEFPSGHTADVLSLSINSLNANMFISGSCDTTVRLWD 234 Query: 261 LEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGTR 317 L + S+ + DGQ G D R++ + G + Sbjct: 235 LRITS--------RAVRTYHGHEGDINSVKFFPDGQRFGTGSDDGTCRLFDMRTGHQ 283 Score = 79.0 bits (193), Expect = 2e-15, Method: Composition-based stats. Identities = 29/155 (18%), Positives = 59/155 (38%), Gaps = 5/155 (3%) Query: 166 VSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGK 225 S + +N + GH+G + ++ +P+ + S +DG+ ++W+ + Sbjct: 40 YSKAQGRTAVSFNPTDLVCCRTLQGHSGKVYSLDWTPEKNWIVSASQDGRLIVWNALTSQ 99 Query: 226 HLYTLDGGDI-INALCFSPNRYWL-CAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEP 283 + + + F+PN + C + I++L + D +S Sbjct: 100 KTHAIKLHCPWVMECAFAPNGQSVACGGLDSACSIFNLSSQA--DRDGNMPVSRVLTGHK 157 Query: 284 PQCTSLAWSADGQT-LFAGYTDNLVRVWQVTIGTR 317 +S + D +T L G D +W VT G R Sbjct: 158 GYASSCQYVPDQETRLITGSGDQTCVLWDVTTGQR 192 >5WLC-LO nrPDB Length = 923 Score = 198 bits (503), Expect = 3e-51, Method: Composition-based stats. Identities = 63/323 (19%), Positives = 130/323 (40%), Gaps = 23/323 (7%) Query: 5 MTLRGTLKGHNGWVTQIATTPQFPDMILSASRD-KTIIMWKLTRDETNYGIPQRALRGHS 63 TL L V ++ Q + + S +++++ + +GH Sbjct: 292 FTLIQQLSMGQNPVNTVSVN-QTGEWLAFGSSKLGQLLVYEWQSESYILKQ-----QGHF 345 Query: 64 HFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSG 123 + + S DG ++ S DG +++WD+T+G F HT V +V F+ + + S Sbjct: 346 DSTNSLAYSPDGSRVVTASEDGKIKVWDITSGFCLATFEEHTSSVTAVQFAKRGQVMFSS 405 Query: 124 SRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKL-VKVWNLANC 182 S D T++ W+ + + + +C+ P S ++ + D + VW++ Sbjct: 406 SLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVDP--SGEVVCAGSLDNFDIHVWSVQTG 463 Query: 183 KLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDL-NEGKHLYTLDGGDIINALCF 241 +L GH G ++ ++ S + S+ AS D +W + + + ++ + AL Sbjct: 464 QLLDALSGHEGPVSCLSFSQENSVLASASWDKTIRIWSIFGRSQQVEPIEVYSDVLALSM 523 Query: 242 SPNRYWLCAAT-GPSIKIW-----------DLEGKIIVDELKQEVISTSSKAEPPQCTSL 289 P+ + +T I I+ D II Q+ + + T++ Sbjct: 524 RPDGKEVAVSTLKGQISIFNIEDAKQVGNIDCRKDIISGRFNQDRFTAKNSERSKFFTTI 583 Query: 290 AWSADGQTLFAGYTDNLVRVWQV 312 +S DG + AG +N + ++ V Sbjct: 584 HYSFDGMAIVAGGNNNSICLYDV 606 Score = 147 bits (370), Expect = 7e-36, Method: Composition-based stats. Identities = 71/380 (18%), Positives = 131/380 (34%), Gaps = 85/380 (22%) Query: 2 TEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRG 61 +E L+ +GH +A +P +++AS D I +W +T G Sbjct: 334 SESYILKQ--QGHFDSTNSLAYSPD-GSRVVTASEDGKIKVWDITS-----GFCLATFEE 385 Query: 62 HSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTK-DVLSVAFSSDNRQI 120 H+ V+ V + GQ S S DGT+R WDL R F G + +A + Sbjct: 386 HTSSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVDPSGEVV 445 Query: 121 VSGSRDK-TIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNL 179 +GS D I +W+ + H VSC+ FS N ++ S WDK +++W++ Sbjct: 446 CAGSLDNFDIHVWSVQ-TGQLLDALSGHEGPVSCLSFS--QENSVLASASWDKTIRIWSI 502 Query: 180 ANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINAL 239 + I + +++ PDG A GQ ++++ + K + +D I + Sbjct: 503 FGRSQQVEPIEVYSDVLALSMRPDGKEVAVSTLKGQISIFNIEDAKQVGNIDCRKDIISG 562 Query: 240 CFSPNRY----------------------WLCAATGPSIKIWDLEGKIIVDEL------- 270 F+ +R+ + SI ++D+ ++++ Sbjct: 563 RFNQDRFTAKNSERSKFFTTIHYSFDGMAIVAGGNNNSICLYDVPNEVLLKRFIVSRNMA 622 Query: 271 -------------------------------------------KQEVISTSSKAEPPQCT 287 + +ST + T Sbjct: 623 LNGTLEFLNSKKMTEAGSLDLIDDAGENSDLEDRIDNSLPGSQRGGDLSTRKMRPEVRVT 682 Query: 288 SLAWSADGQTLFAGYTDNLV 307 S+ +S A T+ L+ Sbjct: 683 SVQFSPTANAFAAASTEGLL 702 Score = 142 bits (358), Expect = 2e-34, Method: Composition-based stats. Identities = 69/345 (20%), Positives = 120/345 (34%), Gaps = 62/345 (17%) Query: 14 HNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGH---SHFVSDVV 70 H + I Q +++S D I+ R + H S V Sbjct: 54 HRKNIAAIDLNKQ-GTLLISIDEDGRAIL---------VNFKARNVLHHFNFKEKCSAVK 103 Query: 71 ISSDGQFALSGSWDGTLRLWDLTTGTTTRRFV---------GHTKDVLSVAFSSDNRQIV 121 S DG+ S L++W R+F GH +D+ S+ +S D+R I+ Sbjct: 104 FSPDGRLFALASG-RFLQIWKTPDVNKDRQFAPFVRHRVHAGHFQDITSLTWSQDSRFIL 162 Query: 122 SGSRDKTIKLW--NTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVW-- 177 + S+D + K+W ++ H ++V FS + I + D V VW Sbjct: 163 TTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGAFFSHDQEK--IYTVSKDGAVFVWEF 220 Query: 178 ---------------------NLANCKLKTN----HIGHTGYLNTVTVSPDGSLCASGGK 212 +++ + + + VT P L A G Sbjct: 221 TKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQAKVKCVTFHPATRLLAVGFT 280 Query: 213 DGQAMLWDLNEGKHLYTLD-GGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELK 271 G+ L+DL + + L G + +N + + WL + G+++V E + Sbjct: 281 SGEFRLYDLPDFTLIQQLSMGQNPVNTVSVNQTGEWLAFGSSK-------LGQLLVYEWQ 333 Query: 272 QEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGT 316 E + SLA+S DG + D ++VW +T G Sbjct: 334 SESYILKQQGHFDSTNSLAYSPDGSRVVTASEDGKIKVWDITSGF 378 Score = 87.8 bits (216), Expect = 5e-18, Method: Composition-based stats. Identities = 33/143 (23%), Positives = 58/143 (40%) Query: 172 KLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLD 231 V V++L N K T H + + ++ G+L S +DG+A+L + L+ + Sbjct: 35 NRVSVFDLINNKSFTFEYEHRKNIAAIDLNKQGTLLISIDEDGRAILVNFKARNVLHHFN 94 Query: 232 GGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAW 291 + +A+ FSP+ A+G ++IW + V TSL W Sbjct: 95 FKEKCSAVKFSPDGRLFALASGRFLQIWKTPDVNKDRQFAPFVRHRVHAGHFQDITSLTW 154 Query: 292 SADGQTLFAGYTDNLVRVWQVTI 314 S D + + D ++W V Sbjct: 155 SQDSRFILTTSKDLSAKIWSVDS 177 Score = 82.4 bits (202), Expect = 2e-16, Method: Composition-based stats. Identities = 46/276 (16%), Positives = 99/276 (35%), Gaps = 38/276 (13%) Query: 69 VVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKT 128 + S DG+ LS + + ++DL + H K++ ++ + ++S D Sbjct: 20 ITFSDDGKQLLSPVGNR-VSVFDLINNKSFTFEYEHRKNIAAIDLNKQGTLLISIDEDGR 78 Query: 129 IKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVW---NLANCKLK 185 L N + + E S V+FSP+ + S + +++W ++ + Sbjct: 79 AILVNFKARN--VLHHFNFKEKCSAVKFSPDGRLFALASG---RFLQIWKTPDVNKDRQF 133 Query: 186 ------TNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKH---LYTLDGG-DI 235 H GH + ++T S D + KD A +W ++ + T +G D Sbjct: 134 APFVRHRVHAGHFQDITSLTWSQDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDY 193 Query: 236 INALCFS-PNRYWLCAATGPSIKIWDLEGK-------IIVDELKQEVISTSSKAE----- 282 + FS + ++ +W+ + D+ KQE + S + Sbjct: 194 VMGAFFSHDQEKIYTVSKDGAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKK 253 Query: 283 ------PPQCTSLAWSADGQTLFAGYTDNLVRVWQV 312 + + + + L G+T R++ + Sbjct: 254 HFFYANQAKVKCVTFHPATRLLAVGFTSGEFRLYDL 289 >5UZ7-B nrPDB Length = 351 Score = 197 bits (501), Expect = 4e-51, Method: Composition-based stats. Identities = 73/316 (23%), Positives = 126/316 (39%), Gaps = 27/316 (8%) Query: 4 QMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHS 63 QM R TL+GH + + +++SAS+D +I+W + IP R S Sbjct: 55 QMRTRRTLRGHLAKIYAMHW-GTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLR-----S 108 Query: 64 HFVSDVVISSDGQFALSGSWDGTLRLWDLTTG----TTTRRFVGHTKDVLSVAFSSDNRQ 119 +V + G + G D +++L T +R GHT + F DN+ Sbjct: 109 SWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQ- 167 Query: 120 IVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNL 179 IV+ S D T LW+ T H+ V + +P++ + VS D K+W++ Sbjct: 168 IVTSSGDTTCALWDIETGQ-QTTTFTGHTGDVMSLSLAPDTR--LFVSGACDASAKLWDV 224 Query: 180 ANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIIN-- 237 + GH +N + P+G+ A+G D L+DL + L T +II Sbjct: 225 REGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGI 284 Query: 238 -ALCFSPNRYWLCAATGP-SIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADG 295 ++ FS + L A + +WD + + + L + DG Sbjct: 285 TSVSFSKSGRLLLAGYDDFNCNVWDALKAD---------RAGVLAGHDNRVSCLGVTDDG 335 Query: 296 QTLFAGYTDNLVRVWQ 311 + G D+ +++W Sbjct: 336 MAVATGSWDSFLKIWN 351 Score = 191 bits (485), Expect = 4e-49, Method: Composition-based stats. Identities = 72/267 (26%), Positives = 120/267 (44%), Gaps = 15/267 (5%) Query: 56 QRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSS 115 +R LRGH + + +D + +S S DG L +WD T + V++ A++ Sbjct: 59 RRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAP 118 Query: 116 DNRQIVSGSRDKTIKLWNT---LGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDK 172 + G D ++N G + + + H+ ++SC RF + IV+ D Sbjct: 119 SGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFL---DDNQIVTSSGDT 175 Query: 173 LVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG 232 +W++ + T GHTG + +++++PD L SG D A LWD+ EG T G Sbjct: 176 TCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTG 235 Query: 233 G-DIINALCFSPNRY-WLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLA 290 INA+CF PN + + + +++DL QE+++ S TS++ Sbjct: 236 HESDINAICFFPNGNAFATGSDDATCRLFDLRA-------DQELMTYSHDNIICGITSVS 288 Query: 291 WSADGQTLFAGYTDNLVRVWQVTIGTR 317 +S G+ L AGY D VW R Sbjct: 289 FSKSGRLLLAGYDDFNCNVWDALKADR 315 Score = 88.2 bits (217), Expect = 4e-18, Method: Composition-based stats. Identities = 29/182 (15%), Positives = 65/182 (35%), Gaps = 16/182 (8%) Query: 139 KYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTV 198 + H + + + + + ++VS D + +W+ + ++ T Sbjct: 57 RTRRTLRGHLAKIYAMHW--GTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTC 114 Query: 199 TVSPDGSLCASGGKDGQAMLWDLNEG----KHLYTLDGGDIINALC-FSPNRYWLCAATG 253 +P G+ A GG D +++L + L G + C F + + ++ Sbjct: 115 AYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGD 174 Query: 254 PSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVT 313 + +WD+E +T+ SL+ + D + +G D ++W V Sbjct: 175 TTCALWDIETGQ---------QTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVR 225 Query: 314 IG 315 G Sbjct: 226 EG 227 >5G04-R nrPDB Length = 499 Score = 196 bits (499), Expect = 7e-51, Method: Composition-based stats. Identities = 63/304 (20%), Positives = 121/304 (39%), Gaps = 29/304 (9%) Query: 21 IATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALS 80 + + +++ A D ++ +W + + + + ++S V +G + Sbjct: 190 VDWS--SGNVLAVA-LDNSVYLWSASSGDI---LQLLQMEQPGEYISSVAWIKEGNYLAV 243 Query: 81 GSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKY 140 G+ ++LWD+ R H+ V S++++ + + SGSR I + + Sbjct: 244 GTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWN--SYILSSGSRSGHIHHHDVRVAEHH 301 Query: 141 TVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCK----LKTNHIGHTGYLN 196 HS+ V +R++P+ + + S G D LV VW A + H G + Sbjct: 302 VATLSGHSQEVCGLRWAPDGRH--LASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVK 359 Query: 197 TVTVSP-DGSLCASGG--KDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATG 253 V P ++ A+GG D +W++ G L +D + ++ +SP+ L + G Sbjct: 360 AVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHG 419 Query: 254 ---PSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVW 310 + IW V ELK + SL S DG T+ + D +R+W Sbjct: 420 FAQNQLVIWKYPTMAKVAELK---------GHTSRVLSLTMSPDGATVASAAADETLRLW 470 Query: 311 QVTI 314 + Sbjct: 471 RCFE 474 Score = 121 bits (303), Expect = 4e-28, Method: Composition-based stats. Identities = 53/225 (23%), Positives = 89/225 (39%), Gaps = 18/225 (8%) Query: 3 EQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGH 62 +Q + H+ V ++ ++ S SR I + E + L GH Sbjct: 256 QQQKRLRNMTSHSARVGSLSWN---SYILSSGSRSGHIHHHDVRVAEHHVA----TLSGH 308 Query: 63 SHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGT----TTRRFVGHTKDVLSVAFSS-DN 117 S V + + DG+ SG D + +W G + F H V +VA+ + Sbjct: 309 SQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQS 368 Query: 118 RQIVSGS--RDKTIKLWNT-LGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLV 174 + +G D+ I++WN G C V ++HS+ V + +SP+ I + Sbjct: 369 NVLATGGGTSDRHIRIWNVCSGACLSAV--DAHSQ-VCSILWSPHYKELISGHGFAQNQL 425 Query: 175 KVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLW 219 +W GHT + ++T+SPDG+ AS D LW Sbjct: 426 VIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470 Score = 81.7 bits (200), Expect = 4e-16, Method: Composition-based stats. Identities = 40/213 (18%), Positives = 84/213 (39%), Gaps = 18/213 (8%) Query: 111 VAFSSDNRQIVSGSRDKTIKLWN-TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCG 169 V +SS N +++ + D ++ LW+ + G +Q E E++S V + + Sbjct: 190 VDWSSGN--VLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIK--EGNYLAVGT 245 Query: 170 WDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKH-LY 228 V++W++ K N H+ + +++ + + +SG + G D+ +H + Sbjct: 246 SSAEVQLWDVQQQKRLRNMTSHSARVGSLSW--NSYILSSGSRSGHIHHHDVRVAEHHVA 303 Query: 229 TLDGGD-IINALCFSPNRYWLCAATGPS-IKIWDLEGKIIVDELKQEVISTSSKAEPPQC 286 TL G + L ++P+ L + + + +W V + Sbjct: 304 TLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGE-----GGWVPLQTFTQHQGAV 358 Query: 287 TSLAWSA-DGQTLFAGY--TDNLVRVWQVTIGT 316 ++AW L G +D +R+W V G Sbjct: 359 KAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGA 391 Score = 42.4 bits (98), Expect = 2e-04, Method: Composition-based stats. Identities = 19/82 (23%), Positives = 33/82 (40%), Gaps = 8/82 (9%) Query: 236 INALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADG 295 +N + +S + L A S+ +W I+ L+ E +S+AW +G Sbjct: 187 LNLVDWS-SGNVLAVALDNSVYLWSASSGDILQLLQMEQPGE-------YISSVAWIKEG 238 Query: 296 QTLFAGYTDNLVRVWQVTIGTR 317 L G + V++W V R Sbjct: 239 NYLAVGTSSAEVQLWDVQQQKR 260 >5I2T-A nrPDB Length = 742 Score = 195 bits (496), Expect = 2e-50, Method: Composition-based stats. Identities = 63/323 (19%), Positives = 130/323 (40%), Gaps = 23/323 (7%) Query: 5 MTLRGTLKGHNGWVTQIATTPQFPDMILSASRD-KTIIMWKLTRDETNYGIPQRALRGHS 63 TL L V ++ Q + + S +++++ + +GH Sbjct: 317 FTLIQQLSMGQNPVNTVSVN-QTGEWLAFGSSKLGQLLVYEWQSESYILKQ-----QGHF 370 Query: 64 HFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSG 123 + + S DG ++ S DG +++WD+T+G F HT V +V F+ + + S Sbjct: 371 DSTNSLAYSPDGSRVVTASEDGKIKVWDITSGFCLATFEEHTSSVTAVQFAKRGQVMFSS 430 Query: 124 SRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKL-VKVWNLANC 182 S D T++ W+ + + + +C+ P S ++ + D + VW++ Sbjct: 431 SLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVDP--SGEVVCAGSLDNFDIHVWSVQTG 488 Query: 183 KLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDL-NEGKHLYTLDGGDIINALCF 241 +L GH G ++ ++ S + S+ AS D +W + + + ++ + AL Sbjct: 489 QLLDALSGHEGPVSCLSFSQENSVLASASWDKTIRIWSIFGRSQQVEPIEVYSDVLALSM 548 Query: 242 SPNRYWLCAAT-GPSIKIW-----------DLEGKIIVDELKQEVISTSSKAEPPQCTSL 289 P+ + +T I I+ D II Q+ + + T++ Sbjct: 549 RPDGKEVAVSTLKGQISIFNIEDAKQVGNIDCRKDIISGRFNQDRFTAKNSERSKFFTTI 608 Query: 290 AWSADGQTLFAGYTDNLVRVWQV 312 +S DG + AG +N + ++ V Sbjct: 609 HYSFDGMAIVAGGNNNSICLYDV 631 Score = 144 bits (364), Expect = 4e-35, Method: Composition-based stats. Identities = 71/380 (18%), Positives = 131/380 (34%), Gaps = 85/380 (22%) Query: 2 TEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRG 61 +E L+ +GH +A +P +++AS D I +W +T G Sbjct: 359 SESYILKQ--QGHFDSTNSLAYSPD-GSRVVTASEDGKIKVWDITS-----GFCLATFEE 410 Query: 62 HSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTK-DVLSVAFSSDNRQI 120 H+ V+ V + GQ S S DGT+R WDL R F G + +A + Sbjct: 411 HTSSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVDPSGEVV 470 Query: 121 VSGSRDK-TIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNL 179 +GS D I +W+ + H VSC+ FS N ++ S WDK +++W++ Sbjct: 471 CAGSLDNFDIHVWSVQ-TGQLLDALSGHEGPVSCLSFS--QENSVLASASWDKTIRIWSI 527 Query: 180 ANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINAL 239 + I + +++ PDG A GQ ++++ + K + +D I + Sbjct: 528 FGRSQQVEPIEVYSDVLALSMRPDGKEVAVSTLKGQISIFNIEDAKQVGNIDCRKDIISG 587 Query: 240 CFSPNRY----------------------WLCAATGPSIKIWDLEGKIIVDEL------- 270 F+ +R+ + SI ++D+ ++++ Sbjct: 588 RFNQDRFTAKNSERSKFFTTIHYSFDGMAIVAGGNNNSICLYDVPNEVLLKRFIVSRNMA 647 Query: 271 -------------------------------------------KQEVISTSSKAEPPQCT 287 + +ST + T Sbjct: 648 LNGTLEFLNSKKMTEAGSLDLIDDAGENSDLEDRIDNSLPGSQRGGDLSTRKMRPEVRVT 707 Query: 288 SLAWSADGQTLFAGYTDNLV 307 S+ +S A T+ L+ Sbjct: 708 SVQFSPTANAFAAASTEGLL 727 Score = 140 bits (352), Expect = 9e-34, Method: Composition-based stats. Identities = 69/345 (20%), Positives = 120/345 (34%), Gaps = 62/345 (17%) Query: 14 HNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGH---SHFVSDVV 70 H + I Q +++S D I+ R + H S V Sbjct: 79 HRKNIAAIDLNKQ-GTLLISIDEDGRAIL---------VNFKARNVLHHFNFKEKCSAVK 128 Query: 71 ISSDGQFALSGSWDGTLRLWDLTTGTTTRRFV---------GHTKDVLSVAFSSDNRQIV 121 S DG+ S L++W R+F GH +D+ S+ +S D+R I+ Sbjct: 129 FSPDGRLFALASG-RFLQIWKTPDVNKDRQFAPFVRHRVHAGHFQDITSLTWSQDSRFIL 187 Query: 122 SGSRDKTIKLW--NTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVW-- 177 + S+D + K+W ++ H ++V FS + I + D V VW Sbjct: 188 TTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGAFFSHDQEK--IYTVSKDGAVFVWEF 245 Query: 178 ---------------------NLANCKLKTN----HIGHTGYLNTVTVSPDGSLCASGGK 212 +++ + + + VT P L A G Sbjct: 246 TKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQAKVKCVTFHPATRLLAVGFT 305 Query: 213 DGQAMLWDLNEGKHLYTLD-GGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELK 271 G+ L+DL + + L G + +N + + WL + G+++V E + Sbjct: 306 SGEFRLYDLPDFTLIQQLSMGQNPVNTVSVNQTGEWLAFGSSK-------LGQLLVYEWQ 358 Query: 272 QEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGT 316 E + SLA+S DG + D ++VW +T G Sbjct: 359 SESYILKQQGHFDSTNSLAYSPDGSRVVTASEDGKIKVWDITSGF 403 Score = 87.1 bits (214), Expect = 1e-17, Method: Composition-based stats. Identities = 33/143 (23%), Positives = 58/143 (40%) Query: 172 KLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLD 231 V V++L N K T H + + ++ G+L S +DG+A+L + L+ + Sbjct: 60 NRVSVFDLINNKSFTFEYEHRKNIAAIDLNKQGTLLISIDEDGRAILVNFKARNVLHHFN 119 Query: 232 GGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAW 291 + +A+ FSP+ A+G ++IW + V TSL W Sbjct: 120 FKEKCSAVKFSPDGRLFALASGRFLQIWKTPDVNKDRQFAPFVRHRVHAGHFQDITSLTW 179 Query: 292 SADGQTLFAGYTDNLVRVWQVTI 314 S D + + D ++W V Sbjct: 180 SQDSRFILTTSKDLSAKIWSVDS 202 Score = 80.9 bits (198), Expect = 7e-16, Method: Composition-based stats. Identities = 46/276 (16%), Positives = 100/276 (36%), Gaps = 38/276 (13%) Query: 69 VVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKT 128 + S DG+ LS + + ++DL + H K++ ++ + ++S D Sbjct: 45 ITFSDDGKQLLSPVGNR-VSVFDLINNKSFTFEYEHRKNIAAIDLNKQGTLLISIDEDGR 103 Query: 129 IKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVW---NLANCKLK 185 L N + + + E S V+FSP+ + S + +++W ++ + Sbjct: 104 AILVNFKA--RNVLHHFNFKEKCSAVKFSPDGRLFALASG---RFLQIWKTPDVNKDRQF 158 Query: 186 ------TNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKH---LYTLDGG-DI 235 H GH + ++T S D + KD A +W ++ + T +G D Sbjct: 159 APFVRHRVHAGHFQDITSLTWSQDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDY 218 Query: 236 INALCFS-PNRYWLCAATGPSIKIWDLEGK-------IIVDELKQEVISTSSKAE----- 282 + FS + ++ +W+ + D+ KQE + S + Sbjct: 219 VMGAFFSHDQEKIYTVSKDGAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKK 278 Query: 283 ------PPQCTSLAWSADGQTLFAGYTDNLVRVWQV 312 + + + + L G+T R++ + Sbjct: 279 HFFYANQAKVKCVTFHPATRLLAVGFTSGEFRLYDL 314 >5YZG-W nrPDB Length = 579 Score = 192 bits (489), Expect = 1e-49, Method: Composition-based stats. Identities = 75/315 (23%), Positives = 120/315 (38%), Gaps = 31/315 (9%) Query: 10 TLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDV 69 GH V+ + P ++LS S D I +W++ + R GHS V D+ Sbjct: 283 VWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERR----CLRTFIGHSKAVRDI 338 Query: 70 VISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQ---IVSGSRD 126 ++ G LS ++D L+LWD TG RF K V F+ D + V+G D Sbjct: 339 CFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNR-KVPYCVKFNPDEDKQNLFVAGMSD 397 Query: 127 KTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLA---NCK 183 K I W+ + + + H V+ + F N VS DK ++VW + K Sbjct: 398 KKIVQWDIRS-GEIVQEYDRHLGAVNTIVFV--DENRRFVSTSDDKSLRVWEWDIPVDFK 454 Query: 184 LKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAML------WDLNEGKHLYTLDGGDIIN 237 H + VT+SP+G A D Q ++ + LN+ K Sbjct: 455 YIAEPSMH--SMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYAC 512 Query: 238 ALCFSPNRYWLCAATGPS-IKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQ 296 + FSP+ ++ + G + IWD + + K P TS Sbjct: 513 QVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETS-------- 564 Query: 297 TLFAGYTDNLVRVWQ 311 + D L+++W Sbjct: 565 KVITCGWDGLIKLWD 579 Score = 118 bits (296), Expect = 3e-27, Method: Composition-based stats. Identities = 50/229 (21%), Positives = 92/229 (40%), Gaps = 17/229 (7%) Query: 95 GTTTRRFVGHTKDVLSVA-FSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSC 153 + GHTK V +V F ++S S D IKLW G + HS+ V Sbjct: 278 KKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRD 337 Query: 154 VRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDG---SLCASG 210 + F N++ +S +D+ +K+W+ + + V +PD +L +G Sbjct: 338 ICF--NTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVP-YCVKFNPDEDKQNLFVAG 394 Query: 211 GKDGQAMLWDLNEGKHLYTLDGG-DIINALCF-SPNRYWLCAATGPSIKIWDLEGKIIVD 268 D + + WD+ G+ + D +N + F NR ++ + S+++W E I VD Sbjct: 395 MSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVW--EWDIPVD 452 Query: 269 ELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGTR 317 ++ ++ S +G+ L DN + ++ R Sbjct: 453 ------FKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFR 495 Score = 114 bits (284), Expect = 7e-26, Method: Composition-based stats. Identities = 35/180 (19%), Positives = 69/180 (38%), Gaps = 15/180 (8%) Query: 137 VCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNL-ANCKLKTNHIGHTGYL 195 K H++ VS VR P S + ++ SC D +K+W + + IGH+ + Sbjct: 277 PKKQIHVWSGHTKGVSAVRLFPLSGHLLL-SCSMDCKIKLWEVYGERRCLRTFIGHSKAV 335 Query: 196 NTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRY----WLCAA 251 + + G+ S D LWD G+ + + + F+P+ ++ Sbjct: 336 RDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPDEDKQNLFVAGM 395 Query: 252 TGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQ 311 + I WD+ IV E + + ++ + + + + D +RVW+ Sbjct: 396 SDKKIVQWDIRSGEIVQEYDRHL---------GAVNTIVFVDENRRFVSTSDDKSLRVWE 446 Score = 41.2 bits (95), Expect = 6e-04, Method: Composition-based stats. Identities = 7/39 (17%), Positives = 12/39 (30%) Query: 6 TLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWK 44 L K H+ P +++ D I +W Sbjct: 541 KLYSRFKAHDKVCIGAVWHPHETSKVITCGWDGLIKLWD 579 >5FVM-C nrPDB Length = 303 Score = 192 bits (489), Expect = 1e-49, Method: Composition-based stats. Identities = 66/296 (22%), Positives = 123/296 (41%), Gaps = 29/296 (9%) Query: 30 MILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRL 89 ++ SA D TI W E G+ R ++ V+ + I+SD ++ + +RL Sbjct: 4 ILASAGYDHTIRFW-----EALTGVCSRTIQHADSQVNRLEITSDKKYLAAAGH-LHVRL 57 Query: 90 WDLTTGTT--TRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESH 147 +D+ + F GH +V S+AF +NR +VS S D TIK+W+ ++ H Sbjct: 58 YDIRSNNPNPVSSFEGHKGNVTSIAFQQENRWMVSSSEDGTIKVWDVRSPS--VQRNYKH 115 Query: 148 SEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHI-GHTGYLNTVTVSPDGSL 206 + V+ V PN ++SC D +++W+L + L +++V+ DGS+ Sbjct: 116 NAPVNEVAIHPNQGE--LISCDQDGNIRIWDLGENQCTNQLTPEDNTPLQSLSVASDGSM 173 Query: 207 CASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLC--------AATGPSIKI 258 +G G +W + TL+ + R L + + ++ Sbjct: 174 LVAGNNKGNCYVWRMPHHTDASTLEPVTKFKSHTKYITRVLLSADVKNLATCSADHTARV 233 Query: 259 WDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTI 314 W++E ++ + A+SAD L +D+ VR+W ++ Sbjct: 234 WNIEDNYQLET--------TLDGHQRWVWDCAFSADSAYLVTACSDHYVRLWDLST 281 Score = 135 bits (339), Expect = 3e-32, Method: Composition-based stats. Identities = 52/245 (21%), Positives = 96/245 (39%), Gaps = 11/245 (4%) Query: 77 FALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLG 136 S +D T+R W+ TG +R V + +SD + + + ++L++ Sbjct: 4 ILASAGYDHTIRFWEALTGVCSRTIQHADSQVNRLEITSDKKYLAAAGH-LHVRLYDIRS 62 Query: 137 VC-KYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYL 195 E H V+ + F N +VS D +KVW++ + ++ N+ H + Sbjct: 63 NNPNPVSSFEGHKGNVTSIAF--QQENRWMVSSSEDGTIKVWDVRSPSVQRNYK-HNAPV 119 Query: 196 NTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTL--DGGDIINALCFSPNRYWLCAATG 253 N V + P+ S +DG +WDL E + L + + +L + + L A Sbjct: 120 NEVAIHPNQGELISCDQDGNIRIWDLGENQCTNQLTPEDNTPLQSLSVASDGSMLVAGNN 179 Query: 254 -PSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQV 312 + +W + L+ T K+ T + SAD + L D+ RVW + Sbjct: 180 KGNCYVWRMPHHTDASTLEP---VTKFKSHTKYITRVLLSADVKNLATCSADHTARVWNI 236 Query: 313 TIGTR 317 + Sbjct: 237 EDNYQ 241 Score = 134 bits (338), Expect = 4e-32, Method: Composition-based stats. Identities = 56/239 (23%), Positives = 102/239 (42%), Gaps = 16/239 (6%) Query: 2 TEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRG 61 + + +GH G VT IA Q ++S+S D TI +W + + Sbjct: 62 SNNPNPVSSFEGHKGNVTSIAFQ-QENRWMVSSSEDGTIKVWDVRS------PSVQRNYK 114 Query: 62 HSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVL-SVAFSSDNRQI 120 H+ V++V I + +S DG +R+WDL T + L S++ +SD + Sbjct: 115 HNAPVNEVAIHPNQGELISCDQDGNIRIWDLGENQCTNQLTPEDNTPLQSLSVASDGSML 174 Query: 121 VSGSRDKTIKLWNTLG-----VCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVK 175 V+G+ +W + + +SH+++++ V S + N + +C D + Sbjct: 175 VAGNNKGNCYVWRMPHHTDASTLEPVTKFKSHTKYITRVLLSADVKN--LATCSADHTAR 232 Query: 176 VWNLA-NCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGG 233 VWN+ N +L+T GH ++ S D + + D LWDL+ + + G Sbjct: 233 VWNIEDNYQLETTLDGHQRWVWDCAFSADSAYLVTACSDHYVRLWDLSTSEIVRQYGGH 291 Score = 84.4 bits (207), Expect = 6e-17, Method: Composition-based stats. Identities = 27/112 (24%), Positives = 51/112 (45%), Gaps = 5/112 (4%) Query: 4 QMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHS 63 + K H ++T++ + + + + S D T +W + + + L GH Sbjct: 196 TLEPVTKFKSHTKYITRVLLSADVKN-LATCSADHTARVWNI----EDNYQLETTLDGHQ 250 Query: 64 HFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSS 115 +V D S+D + ++ D +RLWDL+T R++ GH K + VA + Sbjct: 251 RWVWDCAFSADSAYLVTACSDHYVRLWDLSTSEIVRQYGGHHKGAVCVALND 302 >4GGA-A nrPDB Length = 420 Score = 192 bits (489), Expect = 1e-49, Method: Composition-based stats. Identities = 63/304 (20%), Positives = 121/304 (39%), Gaps = 29/304 (9%) Query: 21 IATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALS 80 + + +++ A D ++ +W + + + + ++S V +G + Sbjct: 111 VDWS--SGNVLAVA-LDNSVYLWSASSGDI---LQLLQMEQPGEYISSVAWIKEGNYLAV 164 Query: 81 GSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKY 140 G+ ++LWD+ R H+ V S++++ + + SGSR I + + Sbjct: 165 GTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWN--SYILSSGSRSGHIHHHDVRVAEHH 222 Query: 141 TVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCK----LKTNHIGHTGYLN 196 HS+ V +R++P+ + + S G D LV VW A + H G + Sbjct: 223 VATLSGHSQEVCGLRWAPDGRH--LASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVK 280 Query: 197 TVTVSP-DGSLCASGG--KDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATG 253 V P ++ A+GG D +W++ G L +D + ++ +SP+ L + G Sbjct: 281 AVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHG 340 Query: 254 ---PSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVW 310 + IW V ELK + SL S DG T+ + D +R+W Sbjct: 341 FAQNQLVIWKYPTMAKVAELK---------GHTSRVLSLTMSPDGATVASAAADETLRLW 391 Query: 311 QVTI 314 + Sbjct: 392 RCFE 395 Score = 119 bits (297), Expect = 2e-27, Method: Composition-based stats. Identities = 53/225 (23%), Positives = 89/225 (39%), Gaps = 18/225 (8%) Query: 3 EQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGH 62 +Q + H+ V ++ ++ S SR I + E + L GH Sbjct: 177 QQQKRLRNMTSHSARVGSLSWN---SYILSSGSRSGHIHHHDVRVAEHHVA----TLSGH 229 Query: 63 SHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGT----TTRRFVGHTKDVLSVAFSS-DN 117 S V + + DG+ SG D + +W G + F H V +VA+ + Sbjct: 230 SQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQS 289 Query: 118 RQIVSGS--RDKTIKLWNT-LGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLV 174 + +G D+ I++WN G C V ++HS+ V + +SP+ I + Sbjct: 290 NVLATGGGTSDRHIRIWNVCSGACLSAV--DAHSQ-VCSILWSPHYKELISGHGFAQNQL 346 Query: 175 KVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLW 219 +W GHT + ++T+SPDG+ AS D LW Sbjct: 347 VIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 391 Score = 79.7 bits (195), Expect = 2e-15, Method: Composition-based stats. Identities = 40/213 (18%), Positives = 84/213 (39%), Gaps = 18/213 (8%) Query: 111 VAFSSDNRQIVSGSRDKTIKLWN-TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCG 169 V +SS N +++ + D ++ LW+ + G +Q E E++S V + + Sbjct: 111 VDWSSGN--VLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIK--EGNYLAVGT 166 Query: 170 WDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKH-LY 228 V++W++ K N H+ + +++ + + +SG + G D+ +H + Sbjct: 167 SSAEVQLWDVQQQKRLRNMTSHSARVGSLSW--NSYILSSGSRSGHIHHHDVRVAEHHVA 224 Query: 229 TLDGGD-IINALCFSPNRYWLCAATGPS-IKIWDLEGKIIVDELKQEVISTSSKAEPPQC 286 TL G + L ++P+ L + + + +W V + Sbjct: 225 TLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGE-----GGWVPLQTFTQHQGAV 279 Query: 287 TSLAWSA-DGQTLFAGY--TDNLVRVWQVTIGT 316 ++AW L G +D +R+W V G Sbjct: 280 KAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGA 312 Score = 41.6 bits (96), Expect = 4e-04, Method: Composition-based stats. Identities = 19/82 (23%), Positives = 33/82 (40%), Gaps = 8/82 (9%) Query: 236 INALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADG 295 +N + +S + L A S+ +W I+ L+ E +S+AW +G Sbjct: 108 LNLVDWS-SGNVLAVALDNSVYLWSASSGDILQLLQMEQPGE-------YISSVAWIKEG 159 Query: 296 QTLFAGYTDNLVRVWQVTIGTR 317 L G + V++W V R Sbjct: 160 NYLAVGTSSAEVQLWDVQQQKR 181 >6QDV-o nrPDB Length = 513 Score = 192 bits (488), Expect = 1e-49, Method: Composition-based stats. Identities = 75/315 (23%), Positives = 120/315 (38%), Gaps = 31/315 (9%) Query: 10 TLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDV 69 GH V+ + P ++LS S D I +W++ + R GHS V D+ Sbjct: 217 VWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERR----CLRTFIGHSKAVRDI 272 Query: 70 VISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQ---IVSGSRD 126 ++ G LS ++D L+LWD TG RF K V F+ D + V+G D Sbjct: 273 CFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNR-KVPYCVKFNPDEDKQNLFVAGMSD 331 Query: 127 KTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLA---NCK 183 K I W+ + + + H V+ + F N VS DK ++VW + K Sbjct: 332 KKIVQWDIRS-GEIVQEYDRHLGAVNTIVFV--DENRRFVSTSDDKSLRVWEWDIPVDFK 388 Query: 184 LKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAML------WDLNEGKHLYTLDGGDIIN 237 H + VT+SP+G A D Q ++ + LN+ K Sbjct: 389 YIAEPSMH--SMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYAC 446 Query: 238 ALCFSPNRYWLCAATGPS-IKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQ 296 + FSP+ ++ + G + IWD + + K P TS Sbjct: 447 QVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETS-------- 498 Query: 297 TLFAGYTDNLVRVWQ 311 + D L+++W Sbjct: 499 KVITCGWDGLIKLWD 513 Score = 118 bits (296), Expect = 3e-27, Method: Composition-based stats. Identities = 50/229 (21%), Positives = 92/229 (40%), Gaps = 17/229 (7%) Query: 95 GTTTRRFVGHTKDVLSVA-FSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSC 153 + GHTK V +V F ++S S D IKLW G + HS+ V Sbjct: 212 KKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRD 271 Query: 154 VRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDG---SLCASG 210 + F N++ +S +D+ +K+W+ + + V +PD +L +G Sbjct: 272 ICF--NTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVP-YCVKFNPDEDKQNLFVAG 328 Query: 211 GKDGQAMLWDLNEGKHLYTLDGG-DIINALCF-SPNRYWLCAATGPSIKIWDLEGKIIVD 268 D + + WD+ G+ + D +N + F NR ++ + S+++W E I VD Sbjct: 329 MSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVW--EWDIPVD 386 Query: 269 ELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGTR 317 ++ ++ S +G+ L DN + ++ R Sbjct: 387 ------FKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFR 429 Score = 113 bits (283), Expect = 8e-26, Method: Composition-based stats. Identities = 35/180 (19%), Positives = 69/180 (38%), Gaps = 15/180 (8%) Query: 137 VCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNL-ANCKLKTNHIGHTGYL 195 K H++ VS VR P S + ++ SC D +K+W + + IGH+ + Sbjct: 211 PKKQIHVWSGHTKGVSAVRLFPLSGHLLL-SCSMDCKIKLWEVYGERRCLRTFIGHSKAV 269 Query: 196 NTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRY----WLCAA 251 + + G+ S D LWD G+ + + + F+P+ ++ Sbjct: 270 RDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPDEDKQNLFVAGM 329 Query: 252 TGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQ 311 + I WD+ IV E + + ++ + + + + D +RVW+ Sbjct: 330 SDKKIVQWDIRSGEIVQEYDRHL---------GAVNTIVFVDENRRFVSTSDDKSLRVWE 380 Score = 41.2 bits (95), Expect = 6e-04, Method: Composition-based stats. Identities = 7/39 (17%), Positives = 12/39 (30%) Query: 6 TLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWK 44 L K H+ P +++ D I +W Sbjct: 475 KLYSRFKAHDKVCIGAVWHPHETSKVITCGWDGLIKLWD 513 >5Z56-q nrPDB Length = 504 Score = 192 bits (488), Expect = 2e-49, Method: Composition-based stats. Identities = 63/320 (19%), Positives = 126/320 (39%), Gaps = 27/320 (8%) Query: 3 EQMTLRGTLKGHNG-------WVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIP 55 E+++ + H G + + P + IL+ DK ++++ + ++ Sbjct: 202 EELSKYRQVASHVGLHSASIPGILALDLCPSDTNKILTGGADKNVVVFDKSSEQI----- 256 Query: 56 QRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSS 115 L+GH+ V+ VV S S D T+R+W + + + H V ++ + Sbjct: 257 LATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHA 316 Query: 116 DNRQIVSGSRDKTIKLWNT-LGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLV 174 ++S S D+ + G V DE+ ++C +F P+ I + D + Sbjct: 317 TGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDG--LIFGTGTMDSQI 374 Query: 175 KVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYT--LDG 232 K+W+L N GH+G + ++ S +G A+ D LWDL + K+ T LD Sbjct: 375 KIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDN 434 Query: 233 GDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWS 292 + +L F + +L G ++I+ KQ T +A+ Sbjct: 435 NFEVKSLIFDQSGTYLALG-GTDVQIYIC---------KQWTEILHFTEHSGLTTGVAFG 484 Query: 293 ADGQTLFAGYTDNLVRVWQV 312 + + + D ++ + + Sbjct: 485 HHAKFIASTGMDRSLKFYSL 504 Score = 130 bits (327), Expect = 8e-31, Method: Composition-based stats. Identities = 43/210 (20%), Positives = 82/210 (39%), Gaps = 17/210 (8%) Query: 109 LSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSC 168 L + S N+ I++G DK + +++ + + H++ V+ V F P+ ++ S Sbjct: 227 LDLCPSDTNK-ILTGGADKNVVVFD-KSSEQILATLKGHTKKVTSVVFHPSQD--LVFSA 282 Query: 169 GWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLY 228 D +++W++ N H + +++ G S D D+ G+ L Sbjct: 283 SPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLT 342 Query: 229 TLDGGDIINALC---FSPNRYWLCAAT-GPSIKIWDLEGKIIVDELKQEVISTSSKAEPP 284 + +L F P+ T IKIWDL+ + V Sbjct: 343 KVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFP---------GHSG 393 Query: 285 QCTSLAWSADGQTLFAGYTDNLVRVWQVTI 314 TS+A+S +G L D+ V++W + Sbjct: 394 PITSIAFSENGYYLATAADDSSVKLWDLRK 423 Score = 72.4 bits (176), Expect = 3e-13, Method: Composition-based stats. Identities = 25/125 (20%), Positives = 50/125 (40%), Gaps = 12/125 (9%) Query: 195 LNTVTVSP-DGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDI-INALCFSPNRYWL-CAA 251 + + + P D + +GG D +++D + + L TL G + ++ F P++ + A+ Sbjct: 224 ILALDLCPSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSAS 283 Query: 252 TGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQ 311 +I+IW + V ++ A T L+ A G L + D Sbjct: 284 PDATIRIWSVPNASCVQVVR---------AHESAVTGLSLHATGDYLLSSSDDQYWAFSD 334 Query: 312 VTIGT 316 + G Sbjct: 335 IQTGR 339 >5L9T-R nrPDB Length = 493 Score = 191 bits (485), Expect = 4e-49, Method: Composition-based stats. Identities = 67/291 (23%), Positives = 120/291 (41%), Gaps = 17/291 (5%) Query: 31 ILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLW 90 +LS + +W + + ++ G V+ V S G G+ G +++W Sbjct: 200 VLSVGLGTCVYLWSACTSQ-VTRLCDLSVEG--DSVTSVGWSERGNLVAVGTHKGFVQIW 256 Query: 91 DLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYT-VQDESHSE 149 D G GHT V ++A++++ Q+ SGSRD+ I + + + + H + Sbjct: 257 DAAAGKKLSMLEGHTARVGALAWNAE--QLSSGSRDRMILQRDIRTPPLQSERRLQGHRQ 314 Query: 150 WVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSP-DGSLCA 208 V +++S + + ++ S G D + VWN ++ + H + + SP L A Sbjct: 315 EVCGLKWS--TDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLA 372 Query: 209 SGG--KDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKII 266 SGG D W+ G+ L +D G + L +S + L + G S + +I+ Sbjct: 373 SGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGYS------QNQIL 426 Query: 267 VDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGTR 317 V + + LA S DG+ + G D +R W V TR Sbjct: 427 VWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKTR 477 Score = 128 bits (322), Expect = 3e-30, Method: Composition-based stats. Identities = 50/219 (22%), Positives = 91/219 (41%), Gaps = 11/219 (5%) Query: 11 LKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVV 70 L+GH V +A + + S SRD+ I+ + T +R L+GH V + Sbjct: 267 LEGHTARVGALAWN---AEQLSSGSRDRMILQRDI---RTPPLQSERRLQGHRQEVCGLK 320 Query: 71 ISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNR-QIVSGS--RDK 127 S+D Q SG D L +W+ ++ + +++ H V ++A+S + SG D+ Sbjct: 321 WSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADR 380 Query: 128 TIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTN 187 I+ WNTL +Q V + +S +++ + + VW + Sbjct: 381 CIRFWNTLTGQP--LQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAK 438 Query: 188 HIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKH 226 GH+ + + +SPDG +G D W++ Sbjct: 439 LTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKTR 477 Score = 86.7 bits (213), Expect = 1e-17, Method: Composition-based stats. Identities = 36/180 (20%), Positives = 68/180 (37%), Gaps = 15/180 (8%) Query: 5 MTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSH 64 + L+GH V + + ++ S D +++W + P + H Sbjct: 303 LQSERRLQGHRQEVCGLKWSTDH-QLLASGGNDNKLLVWNHSS-----LSPVQQYTEHLA 356 Query: 65 FVSDVVISSDGQ-FALSGS--WDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIV 121 V + S SG D +R W+ TG + + V ++A+S ++V Sbjct: 357 AVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPL-QCIDTGSQVCNLAWSKHANELV 415 Query: 122 S--GSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNL 179 S G I +W + + + HS V + SP+ IV+ D+ ++ WN+ Sbjct: 416 STHGYSQNQILVWKYPSLTQ-VAKLTGHSYRVLYLAMSPDGEA--IVTGAGDETLRFWNV 472 Score = 75.1 bits (183), Expect = 4e-14, Method: Composition-based stats. Identities = 31/132 (23%), Positives = 51/132 (38%), Gaps = 10/132 (7%) Query: 14 HNGWVTQIATTPQFPDMILSAS--RDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVI 71 H V IA +P ++ S D+ I W + I V ++ Sbjct: 354 HLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDT------GSQVCNLAW 407 Query: 72 SSDGQFALS--GSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTI 129 S +S G + +W + T + GH+ VL +A S D IV+G+ D+T+ Sbjct: 408 SKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETL 467 Query: 130 KLWNTLGVCKYT 141 + WN + T Sbjct: 468 RFWNVFSKTRST 479 Score = 36.2 bits (82), Expect = 0.019, Method: Composition-based stats. Identities = 12/56 (21%), Positives = 24/56 (42%), Gaps = 1/56 (1%) Query: 4 QMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRAL 59 +T L GH+ V +A +P + I++ + D+T+ W + + L Sbjct: 432 SLTQVAKLTGHSYRVLYLAMSPD-GEAIVTGAGDETLRFWNVFSKTRSTKESVSVL 486 >5LCW-Q nrPDB Length = 374 Score = 190 bits (483), Expect = 6e-49, Method: Composition-based stats. Identities = 63/304 (20%), Positives = 121/304 (39%), Gaps = 29/304 (9%) Query: 21 IATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALS 80 + + +++ A D ++ +W + + + + ++S V +G + Sbjct: 65 VDWS--SGNVLAVA-LDNSVYLWSASSGDI---LQLLQMEQPGEYISSVAWIKEGNYLAV 118 Query: 81 GSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKY 140 G+ ++LWD+ R H+ V S++++ + + SGSR I + + Sbjct: 119 GTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWN--SYILSSGSRSGHIHHHDVRVAEHH 176 Query: 141 TVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCK----LKTNHIGHTGYLN 196 HS+ V +R++P+ + + S G D LV VW A + H G + Sbjct: 177 VATLSGHSQEVCGLRWAPDGRH--LASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVK 234 Query: 197 TVTVSP-DGSLCASGG--KDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATG 253 V P ++ A+GG D +W++ G L +D + ++ +SP+ L + G Sbjct: 235 AVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHG 294 Query: 254 ---PSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVW 310 + IW V ELK + SL S DG T+ + D +R+W Sbjct: 295 FAQNQLVIWKYPTMAKVAELK---------GHTSRVLSLTMSPDGATVASAAADETLRLW 345 Query: 311 QVTI 314 + Sbjct: 346 RCFE 349 Score = 117 bits (293), Expect = 6e-27, Method: Composition-based stats. Identities = 53/225 (23%), Positives = 89/225 (39%), Gaps = 18/225 (8%) Query: 3 EQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGH 62 +Q + H+ V ++ ++ S SR I + E + L GH Sbjct: 131 QQQKRLRNMTSHSARVGSLSWN---SYILSSGSRSGHIHHHDVRVAEHHVA----TLSGH 183 Query: 63 SHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGT----TTRRFVGHTKDVLSVAFSS-DN 117 S V + + DG+ SG D + +W G + F H V +VA+ + Sbjct: 184 SQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQS 243 Query: 118 RQIVSGS--RDKTIKLWNT-LGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLV 174 + +G D+ I++WN G C V ++HS+ V + +SP+ I + Sbjct: 244 NVLATGGGTSDRHIRIWNVCSGACLSAV--DAHSQ-VCSILWSPHYKELISGHGFAQNQL 300 Query: 175 KVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLW 219 +W GHT + ++T+SPDG+ AS D LW Sbjct: 301 VIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 345 Score = 78.6 bits (192), Expect = 4e-15, Method: Composition-based stats. Identities = 40/213 (18%), Positives = 84/213 (39%), Gaps = 18/213 (8%) Query: 111 VAFSSDNRQIVSGSRDKTIKLWN-TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCG 169 V +SS N +++ + D ++ LW+ + G +Q E E++S V + + Sbjct: 65 VDWSSGN--VLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIK--EGNYLAVGT 120 Query: 170 WDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKH-LY 228 V++W++ K N H+ + +++ + + +SG + G D+ +H + Sbjct: 121 SSAEVQLWDVQQQKRLRNMTSHSARVGSLSW--NSYILSSGSRSGHIHHHDVRVAEHHVA 178 Query: 229 TLDGGD-IINALCFSPNRYWLCAATGPS-IKIWDLEGKIIVDELKQEVISTSSKAEPPQC 286 TL G + L ++P+ L + + + +W V + Sbjct: 179 TLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGE-----GGWVPLQTFTQHQGAV 233 Query: 287 TSLAWSA-DGQTLFAGY--TDNLVRVWQVTIGT 316 ++AW L G +D +R+W V G Sbjct: 234 KAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGA 266 Score = 41.2 bits (95), Expect = 6e-04, Method: Composition-based stats. Identities = 19/82 (23%), Positives = 33/82 (40%), Gaps = 8/82 (9%) Query: 236 INALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADG 295 +N + +S + L A S+ +W I+ L+ E +S+AW +G Sbjct: 62 LNLVDWS-SGNVLAVALDNSVYLWSASSGDILQLLQMEQPGE-------YISSVAWIKEG 113 Query: 296 QTLFAGYTDNLVRVWQVTIGTR 317 L G + V++W V R Sbjct: 114 NYLAVGTSSAEVQLWDVQQQKR 135 >5NZU-C nrPDB Length = 905 Score = 189 bits (479), Expect = 2e-48, Method: Composition-based stats. Identities = 64/289 (22%), Positives = 118/289 (40%), Gaps = 19/289 (6%) Query: 3 EQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGH 62 E TL T + + V + + +++ + D I ++ E H Sbjct: 45 ETQTLVKTFEVCDLPVRAAKFVAR-KNWVVTGADDMQIRVFNYNTLER-----VHMFEAH 98 Query: 63 SHFVSDVVISSDGQFALSGSWDGTLRLWDLTTG-TTTRRFVGHTKDVLSVAFSS-DNRQI 120 S ++ + + F L+ S D ++LWD + ++ F GHT V+ + + DN Q Sbjct: 99 SDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQF 158 Query: 121 VSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLA 180 S S D+TIK+W LG E H + V+C+ + P ++S D+LVK+W+ Sbjct: 159 ASASLDRTIKVWQ-LGSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQ 217 Query: 181 NCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALC 240 N GH ++ + P+ + +G +DG +W + + TL+ Sbjct: 218 NKTCVQTLEGHAQNVSCASFHPELPIIITGSEDGTVRIWHSSTYRLESTLN--------- 268 Query: 241 FSPNRYWLCAATGPSIKI-WDLEGKIIVDELKQEVISTSSKAEPPQCTS 288 + R W A+ S + + I+ +L +E + S A + Sbjct: 269 YGMERVWCVASLRGSNNVALGYDEGSIIVKLGREEPAMSMDANGKIIWA 317 Score = 172 bits (437), Expect = 1e-43, Method: Composition-based stats. Identities = 58/265 (21%), Positives = 111/265 (41%), Gaps = 18/265 (6%) Query: 56 QRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSS 115 +R L S V V + + L+ ++G++ +W+ T T + F V + F + Sbjct: 8 KRKLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVA 67 Query: 116 DNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVK 175 +V+G+ D I+++N + E+HS+++ C+ P P I++ D L+K Sbjct: 68 RKNWVVTGADDMQIRVFN-YNTLERVHMFEAHSDYIRCIAVHPTQ--PFILTSSDDMLIK 124 Query: 176 VWNL-ANCKLKTNHIGHTGYLNTVTVSP-DGSLCASGGKDGQAMLWDLNEGKHLYTLDGG 233 +W+ GHT Y+ + ++P D + AS D +W L +TL+G Sbjct: 125 LWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGH 184 Query: 234 D-IINALCFSPNR---YWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSL 289 + +N + + Y + A +KIWD + K V L+ + Sbjct: 185 EKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLE---------GHAQNVSCA 235 Query: 290 AWSADGQTLFAGYTDNLVRVWQVTI 314 ++ + + G D VR+W + Sbjct: 236 SFHPELPIIITGSEDGTVRIWHSST 260 Score = 110 bits (275), Expect = 8e-25, Method: Composition-based stats. Identities = 38/224 (16%), Positives = 75/224 (33%), Gaps = 18/224 (8%) Query: 99 RRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSP 158 R+ + V SV +++ + ++ +WN E V +F Sbjct: 9 RKLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVK-TFEVCDLPVRAAKFV- 66 Query: 159 NSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAML 218 + +V+ D ++V+N + H+ Y+ + V P + D L Sbjct: 67 -ARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKL 125 Query: 219 WDL-NEGKHLYTLDGGDI-INALCFSP--NRYWLCAATGPSIKIWDLEGKIIVDELKQEV 274 WD + +G + + +P N + A+ +IK+W L L+ Sbjct: 126 WDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLE--- 182 Query: 275 ISTSSKAEPPQCTSLAWSADGQ--TLFAGYTDNLVRVWQVTIGT 316 + + + G L +G D LV++W T Sbjct: 183 ------GHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKT 220 Score = 38.9 bits (89), Expect = 0.003, Method: Composition-based stats. Identities = 14/85 (16%), Positives = 31/85 (36%), Gaps = 10/85 (11%) Query: 234 DIINALCFSPNRYWLCAA-TGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWS 292 D + ++ P W+ A+ S+ +W+ E + +V + + + + Sbjct: 16 DRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLP---------VRAAKFV 66 Query: 293 ADGQTLFAGYTDNLVRVWQVTIGTR 317 A + G D +RV+ R Sbjct: 67 ARKNWVVTGADDMQIRVFNYNTLER 91 >6EMK-B nrPDB Length = 303 Score = 187 bits (474), Expect = 6e-48, Method: Composition-based stats. Identities = 67/296 (22%), Positives = 126/296 (42%), Gaps = 29/296 (9%) Query: 30 MILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRL 89 +++SA D TI W E G+ R ++ V+ + I++D + + +RL Sbjct: 4 ILVSAGYDHTIRFW-----EALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGH-QNVRL 57 Query: 90 WDLTT--GTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESH 147 +D+ T F GH +V SV+F DNR +V+ S D TIK+W+ ++ H Sbjct: 58 YDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPS--IPRNYKH 115 Query: 148 SEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTG-YLNTVTVSPDGSL 206 + V+ V PN ++SC D +++W+L + L +++++ DGS+ Sbjct: 116 NAPVNEVVIHPNQGE--LISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSM 173 Query: 207 CASGGKDGQAMLWDLN------EGKHLYTLDGGDII--NALCFSPNRYWLCAATGPSIKI 258 A+ G +W++ K + L S ++ + + ++ Sbjct: 174 LAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARV 233 Query: 259 WDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTI 314 W ++ D+ K E T+ A+SAD L +D+ VR+W ++ Sbjct: 234 WSID-----DDFKLE---TTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLST 281 Score = 133 bits (335), Expect = 9e-32, Method: Composition-based stats. Identities = 53/245 (21%), Positives = 101/245 (41%), Gaps = 11/245 (4%) Query: 77 FALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLG 136 +S +D T+R W+ TG +R V + ++D + + + + ++L++ Sbjct: 4 ILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGH-QNVRLYDIRT 62 Query: 137 VC-KYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYL 195 E H V+ V F N +V+ D +KVW++ + + N+ H + Sbjct: 63 TNPNPVASFEGHRGNVTSVSF--QQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAPV 119 Query: 196 NTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTL--DGGDIINALCFSPNRYWLCAA-T 252 N V + P+ S +DG +WDL E + + L + + +L + + L AA T Sbjct: 120 NEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANT 179 Query: 253 GPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQV 312 + +W++ LK T +A T + S+D + L D+ RVW + Sbjct: 180 KGNCYVWEMPNHTDASHLKP---VTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSI 236 Query: 313 TIGTR 317 + Sbjct: 237 DDDFK 241 Score = 131 bits (329), Expect = 5e-31, Method: Composition-based stats. Identities = 53/239 (22%), Positives = 101/239 (42%), Gaps = 16/239 (6%) Query: 2 TEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRG 61 T + +GH G VT ++ Q ++++S D TI +W + IP+ Sbjct: 62 TTNPNPVASFEGHRGNVTSVSFQ-QDNRWMVTSSEDGTIKVWDVRS----PSIPRN--YK 114 Query: 62 HSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVL-SVAFSSDNRQI 120 H+ V++VVI + +S DG +R+WDL T + L S++ +SD + Sbjct: 115 HNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSML 174 Query: 121 VSGSRDKTIKLWN-----TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVK 175 + + +W K + +HS +++ + S + + + +C D + Sbjct: 175 AAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKH--LATCSADHTAR 232 Query: 176 VWNLAN-CKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGG 233 VW++ + KL+T GH ++ S D + + D LWDL+ + + G Sbjct: 233 VWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGH 291 Score = 86.3 bits (212), Expect = 2e-17, Method: Composition-based stats. Identities = 29/111 (26%), Positives = 52/111 (46%), Gaps = 5/111 (4%) Query: 5 MTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSH 64 + + H+ ++T+I + + + S D T +W + D + L GH Sbjct: 197 LKPVTKFRAHSTYITRILLSSDVKH-LATCSADHTARVWSIDDD----FKLETTLDGHQR 251 Query: 65 FVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSS 115 +V D S+D + ++ S D +RLWDL+T R++ GH K + VA + Sbjct: 252 WVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALND 302 >4LG8-A nrPDB Length = 354 Score = 185 bits (470), Expect = 2e-47, Method: Composition-based stats. Identities = 63/320 (19%), Positives = 126/320 (39%), Gaps = 27/320 (8%) Query: 3 EQMTLRGTLKGHNG-------WVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIP 55 E+++ + H G + + P + IL+ DK ++++ + ++ Sbjct: 52 EELSKYRQVASHVGLHSASIPGILALDLCPSDTNKILTGGADKNVVVFDKSSEQI----- 106 Query: 56 QRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSS 115 L+GH+ V+ VV S S D T+R+W + + + H V ++ + Sbjct: 107 LATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHA 166 Query: 116 DNRQIVSGSRDKTIKLWNT-LGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLV 174 ++S S D+ + G V DE+ ++C +F P+ I + D + Sbjct: 167 TGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDG--LIFGTGTMDSQI 224 Query: 175 KVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYT--LDG 232 K+W+L N GH+G + ++ S +G A+ D LWDL + K+ T LD Sbjct: 225 KIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDN 284 Query: 233 GDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWS 292 + +L F + +L G ++I+ KQ T +A+ Sbjct: 285 NFEVKSLIFDQSGTYLALG-GTDVQIYIC---------KQWTEILHFTEHSGLTTGVAFG 334 Query: 293 ADGQTLFAGYTDNLVRVWQV 312 + + + D ++ + + Sbjct: 335 HHAKFIASTGMDRSLKFYSL 354 Score = 125 bits (314), Expect = 2e-29, Method: Composition-based stats. Identities = 43/210 (20%), Positives = 82/210 (39%), Gaps = 17/210 (8%) Query: 109 LSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSC 168 L + S N+ I++G DK + +++ + + H++ V+ V F P+ ++ S Sbjct: 77 LDLCPSDTNK-ILTGGADKNVVVFD-KSSEQILATLKGHTKKVTSVVFHPSQD--LVFSA 132 Query: 169 GWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLY 228 D +++W++ N H + +++ G S D D+ G+ L Sbjct: 133 SPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLT 192 Query: 229 TLDGGDIINALC---FSPNRYWLCAAT-GPSIKIWDLEGKIIVDELKQEVISTSSKAEPP 284 + +L F P+ T IKIWDL+ + V Sbjct: 193 KVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFP---------GHSG 243 Query: 285 QCTSLAWSADGQTLFAGYTDNLVRVWQVTI 314 TS+A+S +G L D+ V++W + Sbjct: 244 PITSIAFSENGYYLATAADDSSVKLWDLRK 273 Score = 69.7 bits (169), Expect = 2e-12, Method: Composition-based stats. Identities = 25/125 (20%), Positives = 50/125 (40%), Gaps = 12/125 (9%) Query: 195 LNTVTVSP-DGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDI-INALCFSPNRYWL-CAA 251 + + + P D + +GG D +++D + + L TL G + ++ F P++ + A+ Sbjct: 74 ILALDLCPSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSAS 133 Query: 252 TGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQ 311 +I+IW + V ++ A T L+ A G L + D Sbjct: 134 PDATIRIWSVPNASCVQVVR---------AHESAVTGLSLHATGDYLLSSSDDQYWAFSD 184 Query: 312 VTIGT 316 + G Sbjct: 185 IQTGR 189 >4N14-A nrPDB Length = 314 Score = 184 bits (467), Expect = 4e-47, Method: Composition-based stats. Identities = 63/304 (20%), Positives = 121/304 (39%), Gaps = 29/304 (9%) Query: 21 IATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALS 80 + + +L+ + D ++ +W + + + + ++S V +G + Sbjct: 27 VDWS---SGNVLAVALDNSVYLWSASSGDI---LQLLQMEQPGEYISSVAWIKEGNYLAV 80 Query: 81 GSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKY 140 G+ ++LWD+ R H+ V S++++ + + SGSR I + + Sbjct: 81 GTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWN--SYILSSGSRSGHIHHHDVRVAEHH 138 Query: 141 TVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCK----LKTNHIGHTGYLN 196 HS+ V +R++P+ + + S G D LV VW A + H G + Sbjct: 139 VATLSGHSQEVCGLRWAPDGRH--LASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVK 196 Query: 197 TVTVSP-DGSLCASGG--KDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATG 253 V P ++ A+GG D +W++ G L +D + ++ +SP+ L + G Sbjct: 197 AVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHG 256 Query: 254 ---PSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVW 310 + IW V ELK + SL S DG T+ + D +R+W Sbjct: 257 FAQNQLVIWKYPTMAKVAELK---------GHTSRVLSLTMSPDGATVASAAADETLRLW 307 Query: 311 QVTI 314 + Sbjct: 308 RCFE 311 Score = 113 bits (283), Expect = 1e-25, Method: Composition-based stats. Identities = 53/225 (23%), Positives = 89/225 (39%), Gaps = 18/225 (8%) Query: 3 EQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGH 62 +Q + H+ V ++ ++ S SR I + E + L GH Sbjct: 93 QQQKRLRNMTSHSARVGSLSWN---SYILSSGSRSGHIHHHDVRVAEHHVA----TLSGH 145 Query: 63 SHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGT----TTRRFVGHTKDVLSVAFSS-DN 117 S V + + DG+ SG D + +W G + F H V +VA+ + Sbjct: 146 SQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQS 205 Query: 118 RQIVSGS--RDKTIKLWNT-LGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLV 174 + +G D+ I++WN G C V ++HS+ V + +SP+ I + Sbjct: 206 NVLATGGGTSDRHIRIWNVCSGACLSAV--DAHSQ-VCSILWSPHYKELISGHGFAQNQL 262 Query: 175 KVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLW 219 +W GHT + ++T+SPDG+ AS D LW Sbjct: 263 VIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 307 Score = 75.1 bits (183), Expect = 3e-14, Method: Composition-based stats. Identities = 40/213 (18%), Positives = 84/213 (39%), Gaps = 18/213 (8%) Query: 111 VAFSSDNRQIVSGSRDKTIKLWN-TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCG 169 V +SS N +++ + D ++ LW+ + G +Q E E++S V + + Sbjct: 27 VDWSSGN--VLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIK--EGNYLAVGT 82 Query: 170 WDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKH-LY 228 V++W++ K N H+ + +++ + + +SG + G D+ +H + Sbjct: 83 SSAEVQLWDVQQQKRLRNMTSHSARVGSLSW--NSYILSSGSRSGHIHHHDVRVAEHHVA 140 Query: 229 TLDGGD-IINALCFSPNRYWLCAATGPS-IKIWDLEGKIIVDELKQEVISTSSKAEPPQC 286 TL G + L ++P+ L + + + +W V + Sbjct: 141 TLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGE-----GGWVPLQTFTQHQGAV 195 Query: 287 TSLAWSA-DGQTLFAGY--TDNLVRVWQVTIGT 316 ++AW L G +D +R+W V G Sbjct: 196 KAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGA 228 Score = 40.1 bits (92), Expect = 0.001, Method: Composition-based stats. Identities = 19/82 (23%), Positives = 33/82 (40%), Gaps = 8/82 (9%) Query: 236 INALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADG 295 +N + +S + L A S+ +W I+ L+ E +S+AW +G Sbjct: 24 LNLVDWS-SGNVLAVALDNSVYLWSASSGDILQLLQMEQPGE-------YISSVAWIKEG 75 Query: 296 QTLFAGYTDNLVRVWQVTIGTR 317 L G + V++W V R Sbjct: 76 NYLAVGTSSAEVQLWDVQQQKR 97 >5WBU-D nrPDB Length = 328 Score = 183 bits (465), Expect = 8e-47, Method: Composition-based stats. Identities = 62/301 (20%), Positives = 117/301 (38%), Gaps = 21/301 (6%) Query: 27 FPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGT 86 P ++ +A D T+ W + + GI R ++ V+ + ++ D + + Sbjct: 13 DPVILATAGYDHTVRFW-----QAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQH- 66 Query: 87 LRLWDLTTGTTTR--RFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQD 144 +R++DL + + G K++ SV F D R + +G D T ++W+ + Sbjct: 67 IRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRI 126 Query: 145 ESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDG 204 + ++CV PN + I+ + +W+L + + + + PD Sbjct: 127 FQVNAPINCVCLHPNQAELIV--GDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDA 184 Query: 205 SLCASGGKDGQAMLWDLNE--GKHLYTLDGGDIINALC-------FSPNRYWLC-AATGP 254 S A+ G +W+L G + L I A FSP+ L + Sbjct: 185 SYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQ 244 Query: 255 SIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTI 314 + KIW ++ EL + + + A+S D Q + +DNL R+W V Sbjct: 245 TCKIWRTSNFSLMTELSIKSGNPGESSR-GWMWGCAFSGDSQYIVTASSDNLARLWCVET 303 Query: 315 G 315 G Sbjct: 304 G 304 Score = 112 bits (279), Expect = 3e-25, Method: Composition-based stats. Identities = 43/246 (17%), Positives = 84/246 (34%), Gaps = 23/246 (9%) Query: 15 NGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSD 74 N + + + + + D T +W L QR + + ++ V + + Sbjct: 87 NKNIASVGFH-EDGRWMYTGGEDCTARIWDLRSRNLQ---CQRIFQ-VNAPINCVCLHPN 141 Query: 75 GQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNT 134 + G G + +WDL T + + S D + + + +WN Sbjct: 142 QAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNL 201 Query: 135 LG-------VCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTN 187 G + +H+ + RFSP+S+ ++ +C D+ K+W +N L T Sbjct: 202 TGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDST--LLATCSADQTCKIWRTSNFSLMTE 259 Query: 188 H--------IGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGD-IINA 238 G++ S D + D A LW + G+ G + Sbjct: 260 LSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVC 319 Query: 239 LCFSPN 244 L F+ + Sbjct: 320 LAFNDS 325 Score = 74.3 bits (181), Expect = 7e-14, Method: Composition-based stats. Identities = 25/115 (21%), Positives = 50/115 (43%), Gaps = 4/115 (3%) Query: 4 QMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRAL---R 60 Q+ + + H + Q +P ++ + S D+T +W+ + + ++ Sbjct: 211 QLIPKTKIPAHTRYALQCRFSPD-STLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGE 269 Query: 61 GHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSS 115 ++ S D Q+ ++ S D RLW + TG R + GH K V+ +AF+ Sbjct: 270 SSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFND 324 Score = 74.0 bits (180), Expect = 9e-14, Method: Composition-based stats. Identities = 38/242 (15%), Positives = 62/242 (25%), Gaps = 87/242 (35%) Query: 160 SSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSP----------------- 202 S I+ + G+D V+ W + +N + V+P Sbjct: 12 SDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYD 71 Query: 203 --------------------------DGSLCASGGKDGQAMLWDLNEG--KHLYTLDGGD 234 DG +GG+D A +WDL + Sbjct: 72 LNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNA 131 Query: 235 IINALCFSPNRYWLCAAT-GPSIKIWDLE------------------------------- 262 IN +C PN+ L +I IWDL+ Sbjct: 132 PINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVN 191 Query: 263 --GKIIVDELKQEVISTSSK--------AEPPQCTSLAWSADGQTLFAGYTDNLVRVWQV 312 G V L + ++ A +S D L D ++W+ Sbjct: 192 STGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRT 251 Query: 313 TI 314 + Sbjct: 252 SN 253 Score = 70.9 bits (172), Expect = 6e-13, Method: Composition-based stats. Identities = 28/117 (23%), Positives = 46/117 (39%), Gaps = 8/117 (6%) Query: 199 TVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDI-INALCFSPNRYWLCAATGPSIK 257 TV D + A+ G D W + G T+ D +NAL +P+R + AA I+ Sbjct: 9 TVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIR 68 Query: 258 IWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTI 314 ++DL S S+ + DG+ ++ G D R+W + Sbjct: 69 MYDLNSNNPN-------PIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRS 118 >5GAN-H nrPDB Length = 465 Score = 182 bits (463), Expect = 1e-46, Method: Composition-based stats. Identities = 69/262 (26%), Positives = 110/262 (41%), Gaps = 10/262 (3%) Query: 5 MTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSH 64 L L H G + I P + ++S + D I ++ + +E + L GH Sbjct: 208 QPLTQKLDSHVGKIGAIDWHPDSNNQMISCAEDGLIKNFQYSNEEGGLRLLGD-LVGHER 266 Query: 65 FVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGS 124 +SDV G+F S S D T RLWD +T GH K V S++F D + SG Sbjct: 267 RISDVKYHPSGKFIGSASHDMTWRLWDASTHQELLLQEGHDKGVFSLSFQCDGSLVCSGG 326 Query: 125 RDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCK- 183 D LW+ K + HS+ + V +SPN + + G D ++ VW++ Sbjct: 327 MDSLSMLWDIRSGSK-VMTLAGHSKPIYTVAWSPNGYQ--VATGGGDGIINVWDIRKRDE 383 Query: 184 -LKTNHIGHTGYLNTVTVSPD--GSLCASGGKDGQAMLWDLNEGKHLYTLDGG-DIINAL 239 + H + V S + G S G D ++ + + +L G D I +L Sbjct: 384 GQLNQILAHRNIVTQVRFSKEDGGKKLVSCGYDNLINVYSSDTWLKMGSLAGHTDKIISL 443 Query: 240 CFSPNRYWLCAAT-GPSIKIWD 260 S N ++L + SIK+W+ Sbjct: 444 DISNNSHFLVSGGWDRSIKLWN 465 Score = 167 bits (424), Expect = 4e-42, Method: Composition-based stats. Identities = 57/308 (18%), Positives = 116/308 (37%), Gaps = 28/308 (9%) Query: 15 NGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSD 74 ++ ++ + ++ + S + + + + L H + + D Sbjct: 175 TKPISAVSLSTDD-MVVATGSWAGDLQVLNSQTLQP----LTQKLDSHVGKIGAIDWHPD 229 Query: 75 GQ-FALSGSWDGTLRLWDLTTG----TTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTI 129 +S + DG ++ + + VGH + + V + + I S S D T Sbjct: 230 SNNQMISCAEDGLIKNFQYSNEEGGLRLLGDLVGHERRISDVKYHPSGKFIGSASHDMTW 289 Query: 130 KLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHI 189 +LW+ + + E H + V + F + S ++ S G D L +W++ + Sbjct: 290 RLWDA-STHQELLLQEGHDKGVFSLSFQCDGS--LVCSGGMDSLSMLWDIRSGSKVMTLA 346 Query: 190 GHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLN---EGKHLYTLDGGDIINALCFSPN-- 244 GH+ + TV SP+G A+GG DG +WD+ EG+ L +I+ + FS Sbjct: 347 GHSKPIYTVAWSPNGYQVATGGGDGIINVWDIRKRDEGQLNQILAHRNIVTQVRFSKEDG 406 Query: 245 -RYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYT 303 + + I ++ + + S + SL S + L +G Sbjct: 407 GKKLVSCGYDNLINVYSSDT---------WLKMGSLAGHTDKIISLDISNNSHFLVSGGW 457 Query: 304 DNLVRVWQ 311 D +++W Sbjct: 458 DRSIKLWN 465 Score = 155 bits (391), Expect = 3e-38, Method: Composition-based stats. Identities = 66/261 (25%), Positives = 113/261 (43%), Gaps = 18/261 (6%) Query: 63 SHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTT-RRFVGHTKDVLSVAFSSD-NRQI 120 + +S V +S+D +GSW G L++ + T ++ H + ++ + D N Q+ Sbjct: 175 TKPISAVSLSTDDMVVATGSWAGDLQVLNSQTLQPLTQKLDSHVGKIGAIDWHPDSNNQM 234 Query: 121 VSGSRDKTIKLW---NTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVW 177 +S + D IK + N G + H +S V++ P S I S D ++W Sbjct: 235 ISCAEDGLIKNFQYSNEEGGLRLLGDLVGHERRISDVKYHP--SGKFIGSASHDMTWRLW 292 Query: 178 NLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGD-II 236 + + + GH + +++ DGSL SGG D +MLWD+ G + TL G I Sbjct: 293 DASTHQELLLQEGHDKGVFSLSFQCDGSLVCSGGMDSLSMLWDIRSGSKVMTLAGHSKPI 352 Query: 237 NALCFSPNRYWLCAATGPSI-KIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSAD- 294 + +SPN Y + G I +WD+ + E A T + +S + Sbjct: 353 YTVAWSPNGYQVATGGGDGIINVWDIRKR-------DEGQLNQILAHRNIVTQVRFSKED 405 Query: 295 -GQTLFAGYTDNLVRVWQVTI 314 G+ L + DNL+ V+ Sbjct: 406 GGKKLVSCGYDNLINVYSSDT 426 Score = 78.2 bits (191), Expect = 5e-15, Method: Composition-based stats. Identities = 31/178 (17%), Positives = 70/178 (39%), Gaps = 19/178 (10%) Query: 148 SEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTN-HIGHTGYLNTVTVSPDGS- 205 ++ +S V S + + ++ + W ++V N + T H G + + PD + Sbjct: 175 TKPISAVSLS--TDDMVVATGSWAGDLQVLNSQTLQPLTQKLDSHVGKIGAIDWHPDSNN 232 Query: 206 LCASGGKDGQAMLWDLNEG----KHLYTLDGGDI-INALCFSPNRYWL-CAATGPSIKIW 259 S +DG + + + L L G + I+ + + P+ ++ A+ + ++W Sbjct: 233 QMISCAEDGLIKNFQYSNEEGGLRLLGDLVGHERRISDVKYHPSGKFIGSASHDMTWRLW 292 Query: 260 DLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGTR 317 D + SL++ DG + +G D+L +W + G++ Sbjct: 293 DAST---------HQELLLQEGHDKGVFSLSFQCDGSLVCSGGMDSLSMLWDIRSGSK 341 >6GMH-W nrPDB Length = 305 Score = 178 bits (452), Expect = 2e-45, Method: Composition-based stats. Identities = 65/318 (20%), Positives = 135/318 (42%), Gaps = 21/318 (6%) Query: 1 MTEQM-TLRGTLKGHNGWVTQIAT---TPQFPDMILSASRDKTIIMWKLTRDETNYGIPQ 56 MT Q L + H+ + +A + + +++ S D + +WK + + Q Sbjct: 1 MTNQYGILFKQEQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLD---LQ 57 Query: 57 RALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSD 116 +L GH V V IS A S S D +RLWDL G + D ++AFS D Sbjct: 58 WSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPD 117 Query: 117 NRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKV 176 ++ + +G+ + ++ K ++ +++ + +SP+ + S D ++ + Sbjct: 118 SQYLATGTHVGKVNIFGVES-GKKEYSLDTRGKFILSIAYSPDG--KYLASGAIDGIINI 174 Query: 177 WNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGG-DI 235 +++A KL GH + ++T SPD L + DG ++D+ TL G Sbjct: 175 FDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASW 234 Query: 236 INALCFSP-NRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSAD 294 + + F P + +++ +++ S+K+WD+ + V Q + ++ + Sbjct: 235 VLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFD---------HQDQVWGVKYNGN 285 Query: 295 GQTLFAGYTDNLVRVWQV 312 G + + D + ++ Sbjct: 286 GSKIVSVGDDQEIHIYDC 303 Score = 131 bits (330), Expect = 3e-31, Method: Composition-based stats. Identities = 59/257 (22%), Positives = 102/257 (39%), Gaps = 41/257 (15%) Query: 3 EQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDET------------ 50 E++ L+ +L+GH V + + P + S+S D I +W L + Sbjct: 52 ERLDLQWSLEGHQLGVVSVDISHTLP-IAASSSLDAHIRLWDLENGKQIKSIDAGPVDAW 110 Query: 51 -------------------------NYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDG 85 G + +L F+ + S DG++ SG+ DG Sbjct: 111 TLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDG 170 Query: 86 TLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDE 145 + ++D+ TG GH + S+ FS D++ +V+ S D IK+++ Sbjct: 171 IINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAG-TLS 229 Query: 146 SHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGS 205 H+ WV V F P+ ++ VS DK VKVW++ H + V + +GS Sbjct: 230 GHASWVLNVAFCPDDTH--FVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGS 287 Query: 206 LCASGGKDGQAMLWDLN 222 S G D + ++D Sbjct: 288 KIVSVGDDQEIHIYDCP 304 Score = 127 bits (319), Expect = 6e-30, Method: Composition-based stats. Identities = 63/274 (22%), Positives = 111/274 (40%), Gaps = 20/274 (7%) Query: 49 ETNYGIPQRALRGHSHFVSDVVISSDGQF----ALSGSWDGTLRLWDLTTGTTTR--RFV 102 YGI + + H + V ++ + ++GS D +++W Sbjct: 2 TNQYGILFKQEQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLE 61 Query: 103 GHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSN 162 GH V+SV S S S D I+LW+ + D + + FSP+S Sbjct: 62 GHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDA-WTLAFSPDS-- 118 Query: 163 PIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLN 222 + + V ++ + + K + + ++ ++ SPDG ASG DG ++D+ Sbjct: 119 QYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIA 178 Query: 223 EGKHLYTLDGG-DIINALCFSPNRYWLCAATGPS-IKIWDLEGKIIVDELKQEVISTSSK 280 GK L+TL+G I +L FSP+ L A+ IKI+D++ + L Sbjct: 179 TGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTL---------S 229 Query: 281 AEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTI 314 ++A+ D + +D V+VW V Sbjct: 230 GHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGT 263 Score = 125 bits (314), Expect = 2e-29, Method: Composition-based stats. Identities = 52/230 (22%), Positives = 94/230 (40%), Gaps = 18/230 (7%) Query: 93 TTGTTTRRFVGHTKDVLSVAFSSD----NRQIVSGSRDKTIKLWNTLGVCKYTV-QDESH 147 G ++ H + SVA+ ++ + +V+GS D +K+W E H Sbjct: 4 QYGILFKQEQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGH 63 Query: 148 SEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLC 207 V V + + PI S D +++W+L N K + T+ SPD Sbjct: 64 QLGV--VSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYL 121 Query: 208 ASGGKDGQAMLWDLNEGKHLYTLDG-GDIINALCFSPNRYWLCAAT-GPSIKIWDLEGKI 265 A+G G+ ++ + GK Y+LD G I ++ +SP+ +L + I I+D+ Sbjct: 122 ATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGK 181 Query: 266 IVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIG 315 ++ L+ + SL +S D Q L D ++++ V Sbjct: 182 LLHTLEGHAMP---------IRSLTFSPDSQLLVTASDDGYIKIYDVQHA 222 Score = 94.8 bits (234), Expect = 4e-20, Method: Composition-based stats. Identities = 45/180 (25%), Positives = 76/180 (42%), Gaps = 15/180 (8%) Query: 143 QDESHSEWVSCVRFSPNSSN--PIIVSCGWDKLVKVWNLANCKLKTN--HIGHTGYLNTV 198 Q+++H + + V + N +V+ D LVKVW + +L GH + +V Sbjct: 11 QEQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSV 70 Query: 199 TVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGD-IINALCFSPNRYWLCAATG-PSI 256 +S + AS D LWDL GK + ++D G L FSP+ +L T + Sbjct: 71 DISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKV 130 Query: 257 KIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGT 316 I+ +E L S+A+S DG+ L +G D ++ ++ + G Sbjct: 131 NIFGVESGKKEYSLD---------TRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGK 181 Score = 63.6 bits (153), Expect = 1e-10, Method: Composition-based stats. Identities = 26/144 (18%), Positives = 51/144 (35%), Gaps = 17/144 (11%) Query: 182 CKLKTNHIGHTGYLNTVTVSPD----GSLCASGGKDGQAMLWDLNEGKH--LYTLDGGD- 234 L H + +V + +G D +W + + ++L+G Sbjct: 6 GILFKQEQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQL 65 Query: 235 IINALCFSPNRYWLCAAT-GPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSA 293 + ++ S +++ I++WDLE + + A P +LA+S Sbjct: 66 GVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSID---------AGPVDAWTLAFSP 116 Query: 294 DGQTLFAGYTDNLVRVWQVTIGTR 317 D Q L G V ++ V G + Sbjct: 117 DSQYLATGTHVGKVNIFGVESGKK 140 >4AEZ-A nrPDB Length = 401 Score = 176 bits (446), Expect = 1e-44, Method: Composition-based stats. Identities = 61/292 (20%), Positives = 116/292 (39%), Gaps = 21/292 (7%) Query: 31 ILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLW 90 +++ + ++ + +W + A S +V+ V S DG F G +G + ++ Sbjct: 106 VVAVALERNVYVWNADSG----SVSALAETDESTYVASVKWSHDGSFLSVGLGNGLVDIY 161 Query: 91 DLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEW 150 D+ + T R GH V ++++ + SGSR I + + HS Sbjct: 162 DVESQTKLRTMAGHQARVGCLSWNR--HVLSSGSRSGAIHHHDVRIANHQIGTLQGHSSE 219 Query: 151 VSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSP-DGSLCAS 209 V + + S + S G D +V++W+ + K H + V P +L A+ Sbjct: 220 VCGLAWR--SDGLQLASGGNDNVVQIWDARSSIPKFTKTNHNAAVKAVAWCPWQSNLLAT 277 Query: 210 GGK--DGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAAT---GPSIKIWDLEGK 264 GG D Q W+ G + T+D G + +L +SP+ + + ++ IW Sbjct: 278 GGGTMDKQIHFWNAATGARVNTVDAGSQVTSLIWSPHSKEIMSTHGFPDNNLSIWSYSSS 337 Query: 265 IIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGT 316 + ++ A + A S DG+ L +D ++ W+V G Sbjct: 338 GLTKQVDIP-------AHDTRVLYSALSPDGRILSTAASDENLKFWRVYDGD 382 Score = 117 bits (294), Expect = 4e-27, Method: Composition-based stats. Identities = 51/231 (22%), Positives = 86/231 (37%), Gaps = 14/231 (6%) Query: 3 EQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGH 62 E T T+ GH V ++ ++ S SR I D L+GH Sbjct: 164 ESQTKLRTMAGHQARVGCLSWNR---HVLSSGSRSGAI----HHHDVRIANHQIGTLQGH 216 Query: 63 SHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSS-DNRQIV 121 S V + SDG SG D +++WD + H V +VA+ + + Sbjct: 217 SSEVCGLAWRSDGLQLASGGNDNVVQIWDARSSIPKFTKTNHNAAVKAVAWCPWQSNLLA 276 Query: 122 SGS--RDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNL 179 +G DK I WN + D V+ + +SP+S + D + +W+ Sbjct: 277 TGGGTMDKQIHFWNAATGARVNTVDAGSQ--VTSLIWSPHSKEIMSTHGFPDNNLSIWSY 334 Query: 180 ANCKLKTNHI--GHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLY 228 ++ L H + +SPDG + ++ D W + +G H+ Sbjct: 335 SSSGLTKQVDIPAHDTRVLYSALSPDGRILSTAASDENLKFWRVYDGDHVK 385 Score = 72.4 bits (176), Expect = 2e-13, Method: Composition-based stats. Identities = 34/211 (16%), Positives = 74/211 (35%), Gaps = 19/211 (9%) Query: 113 FSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDK 172 N +V+ + ++ + +WN + + S +V+ V++S + S + + Sbjct: 99 LDWSNLNVVAVALERNVYVWNADSGSVSALAETDESTYVASVKWSHDGS--FLSVGLGNG 156 Query: 173 LVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLN-EGKHLYTLD 231 LV ++++ + GH + ++ + + +SG + G D+ + TL Sbjct: 157 LVDIYDVESQTKLRTMAGHQARVGCLSWNR--HVLSSGSRSGAIHHHDVRIANHQIGTLQ 214 Query: 232 GGD-IINALCFSPNRYWLCAAT-GPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSL 289 G + L + + L + ++IWD I + ++ Sbjct: 215 GHSSEVCGLAWRSDGLQLASGGNDNVVQIWDARSSIP---------KFTKTNHNAAVKAV 265 Query: 290 AWSA-DGQTLFAGY--TDNLVRVWQVTIGTR 317 AW L G D + W G R Sbjct: 266 AWCPWQSNLLATGGGTMDKQIHFWNAATGAR 296 Score = 47.8 bits (112), Expect = 6e-06, Method: Composition-based stats. Identities = 19/94 (20%), Positives = 37/94 (39%), Gaps = 4/94 (4%) Query: 18 VTQIATTPQFPDMILS-ASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQ 76 VT + +P +++ + D + +W + Q + H V +S DG+ Sbjct: 306 VTSLIWSPHSKEIMSTHGFPDNNLSIWSYSSSGL---TKQVDIPAHDTRVLYSALSPDGR 362 Query: 77 FALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLS 110 + + D L+ W + G +R + TK S Sbjct: 363 ILSTAASDENLKFWRVYDGDHVKRPIPITKTPSS 396 Score = 31.6 bits (70), Expect = 0.51, Method: Composition-based stats. Identities = 19/82 (23%), Positives = 34/82 (41%), Gaps = 9/82 (10%) Query: 236 INALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADG 295 +N L +S N + A ++ +W+ + V + + E S+ WS DG Sbjct: 96 LNLLDWS-NLNVVAVALERNVYVWNADSGS--------VSALAETDESTYVASVKWSHDG 146 Query: 296 QTLFAGYTDNLVRVWQVTIGTR 317 L G + LV ++ V T+ Sbjct: 147 SFLSVGLGNGLVDIYDVESQTK 168 >5WYJ-BC nrPDB Length = 817 Score = 175 bits (444), Expect = 2e-44, Method: Composition-based stats. Identities = 53/227 (23%), Positives = 98/227 (43%), Gaps = 16/227 (7%) Query: 5 MTLRGTLKGHNGWVTQIA----TTPQFPDMILSASRDKTIIMWKLTR-----DETNYGIP 55 + GH+ VT + + +P+ +L+AS D TI W + + D + Sbjct: 424 FDIYAKYIGHSAAVTAVGLPNIVSKGYPEFLLTASNDLTIKKWIIPKPTASMDVQIIKVS 483 Query: 56 QRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSS 115 + H ++ + +S + + S+D T ++W+L G H + + V+F Sbjct: 484 EYTRHAHEKDINALSVSPNDSIFATASYDKTCKIWNLENGELEATLANHKRGLWDVSFCQ 543 Query: 116 DNRQIVSGSRDKTIKLW--NTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKL 173 ++ + + S DKT+K+W +T V K E H+ V F + ++SCG D L Sbjct: 544 YDKLLATSSGDKTVKIWSLDTFSVMK---TLEGHTNAVQRCSF--INKQKQLISCGADGL 598 Query: 174 VKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWD 220 +K+W+ ++ + GH L ++ DG + S DG W Sbjct: 599 IKIWDCSSGECLKTLDGHNNRLWALSTMNDGDMIVSADADGVFQFWK 645 Score = 160 bits (405), Expect = 7e-40, Method: Composition-based stats. Identities = 60/332 (18%), Positives = 127/332 (38%), Gaps = 34/332 (10%) Query: 3 EQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMW---KLTRDETNYGIPQRAL 59 + + + ++ G++G + + + + A+ ++ + L+ E + + Sbjct: 325 DTIQVTSSIAGNHGIIADMRYVGPELNKLALATNSPSLRIIPVPDLSGPEASLPLDVEIY 384 Query: 60 RGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTT----RRFVGHTKDVLSVAFSS 115 GH ++ + + DG + + S D T +W + +++GH+ V +V + Sbjct: 385 EGHEDLLNSLDATEDGLWIATASKDNTAIVWRYNENSCKFDIYAKYIGHSAAVTAVGLPN 444 Query: 116 -----DNRQIVSGSRDKTIKLW---------NTLGVCKYTVQDESHSEWVSCVRFSPNSS 161 +++ S D TIK W + + +H + ++ + SPN S Sbjct: 445 IVSKGYPEFLLTASNDLTIKKWIIPKPTASMDVQIIKVSEYTRHAHEKDINALSVSPNDS 504 Query: 162 NPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDL 221 I + +DK K+WNL N +L+ H L V+ L A+ D +W L Sbjct: 505 --IFATASYDKTCKIWNLENGELEATLANHKRGLWDVSFCQYDKLLATSSGDKTVKIWSL 562 Query: 222 NEGKHLYTLDGG-DIINALCF-SPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSS 279 + + TL+G + + F + + + IKIWD + L Sbjct: 563 DTFSVMKTLEGHTNAVQRCSFINKQKQLISCGADGLIKIWDCSSGECLKTLD-------- 614 Query: 280 KAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQ 311 + +L+ DG + + D + + W+ Sbjct: 615 -GHNNRLWALSTMNDGDMIVSADADGVFQFWK 645 Score = 113 bits (283), Expect = 9e-26, Method: Composition-based stats. Identities = 43/233 (18%), Positives = 89/233 (38%), Gaps = 27/233 (11%) Query: 101 FVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNT-LGVCKYTV--QDESHSEWVSCVRFS 157 + GH + S+ + D I + S+D T +W CK+ + + HS V+ V Sbjct: 384 YEGHEDLLNSLDATEDGLWIATASKDNTAIVWRYNENSCKFDIYAKYIGHSAAVTAVGLP 443 Query: 158 PNSSN---PIIVSCGWDKLVKVWNLANCKL----------KTNHIGHTGYLNTVTVSPDG 204 S +++ D +K W + + H +N ++VSP+ Sbjct: 444 NIVSKGYPEFLLTASNDLTIKKWIIPKPTASMDVQIIKVSEYTRHAHEKDINALSVSPND 503 Query: 205 SLCASGGKDGQAMLWDLNEGKHLYTLDGGD-IINALCFSP-NRYWLCAATGPSIKIWDLE 262 S+ A+ D +W+L G+ TL + + F ++ ++ ++KIW L+ Sbjct: 504 SIFATASYDKTCKIWNLENGELEATLANHKRGLWDVSFCQYDKLLATSSGDKTVKIWSLD 563 Query: 263 GKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIG 315 ++ L+ ++ + L + D L+++W + G Sbjct: 564 TFSVMKTLE---------GHTNAVQRCSFINKQKQLISCGADGLIKIWDCSSG 607 Score = 106 bits (264), Expect = 2e-23, Method: Composition-based stats. Identities = 30/132 (22%), Positives = 59/132 (44%), Gaps = 6/132 (4%) Query: 2 TEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRG 61 E L TL H + ++ Q+ ++ ++S DKT+ +W L + + L G Sbjct: 520 LENGELEATLANHKRGLWDVSFC-QYDKLLATSSGDKTVKIWSL-----DTFSVMKTLEG 573 Query: 62 HSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIV 121 H++ V + + +S DG +++WD ++G + GH + +++ +D IV Sbjct: 574 HTNAVQRCSFINKQKQLISCGADGLIKIWDCSSGECLKTLDGHNNRLWALSTMNDGDMIV 633 Query: 122 SGSRDKTIKLWN 133 S D + W Sbjct: 634 SADADGVFQFWK 645 Score = 105 bits (262), Expect = 3e-23, Method: Composition-based stats. Identities = 64/397 (16%), Positives = 124/397 (31%), Gaps = 89/397 (22%) Query: 3 EQMTLRGTLKGHNGWVTQIATTPQFPD---MILSASRDKTIIMWKLTRDETNYGIPQRAL 59 E + + KGH G ++ + Q ++ S + + +W L + + L Sbjct: 132 ENGYITHSFKGHGGTISSLKFYGQLNSKIWLLASGDTNGMVKVWDLVKRK-----CLHTL 186 Query: 60 RGHSHFVSDVVIS--SDGQF----ALSGSWDGTLRLWDLT--TGTTTRRFVGHTKDVLSV 111 + H+ V + I D LSG D + LWD + + + V S Sbjct: 187 QEHTSAVRGLDIIEVPDNDEPSLNLLSGGRDDIINLWDFNMKKKCKLLKTLPVNQQVESC 246 Query: 112 AFSSDN---RQIVSGS-------------------------------------------- 124 F D R I + Sbjct: 247 GFLKDGDGKRIIYTAGGDAIFQLIDSESGSVLKRTNKPIEELFIIGVLPILSNSQMFLVL 306 Query: 125 RDKTIKLWNTL-------GVCKYTVQDESHSEWVSCVRFS-PNSSNPIIVSCGWD-KLVK 175 D+T++L N + T + ++ +R+ P + + + +++ Sbjct: 307 SDQTLQLINVEEDLKNDEDTIQVTSSIAGNHGIIADMRYVGPELNKLALATNSPSLRIIP 366 Query: 176 VWNLANCKL-----KTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKH---- 226 V +L+ + + GH LN++ + DG A+ KD A++W NE Sbjct: 367 VPDLSGPEASLPLDVEIYEGHEDLLNSLDATEDGLWIATASKDNTAIVWRYNENSCKFDI 426 Query: 227 LYTLDGGDIINALCFSPN-------RYWLCAATGPSIKIWDLEGKIIVDELKQ-EVISTS 278 G PN + L A+ +IK W + +++ +V + Sbjct: 427 YAKYIGHSAAVTAVGLPNIVSKGYPEFLLTASNDLTIKKWIIPKPTASMDVQIIKVSEYT 486 Query: 279 SKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIG 315 A +L+ S + D ++W + G Sbjct: 487 RHAHEKDINALSVSPNDSIFATASYDKTCKIWNLENG 523 Score = 92.1 bits (227), Expect = 3e-19, Method: Composition-based stats. Identities = 58/318 (18%), Positives = 103/318 (32%), Gaps = 39/318 (12%) Query: 28 PDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQ----FALSGSW 83 ++ D +II+ + G + +GH +S + SG Sbjct: 114 STLLAVGGTDGSIIVVDIEN-----GYITHSFKGHGGTISSLKFYGQLNSKIWLLASGDT 168 Query: 84 DGTLRLWDLTTGTTTRRFVGHTKDVLSVAF--SSDNR----QIVSGSRDKTIKLWNTLGV 137 +G +++WDL HT V + DN ++SG RD I LW+ Sbjct: 169 NGMVKVWDLVKRKCLHTLQEHTSAVRGLDIIEVPDNDEPSLNLLSGGRDDIINLWDFNMK 228 Query: 138 CKYTVQDESH-SEWVSCVRFSPNSSNP-IIVSCGWDKLVKVWNLANCKLKTN---HIGHT 192 K + ++ V F + II + G D + ++ + + + I Sbjct: 229 KKCKLLKTLPVNQQVESCGFLKDGDGKRIIYTAGGDAIFQLIDSESGSVLKRTNKPIEEL 288 Query: 193 GYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKH---------LYTLDGGDIINALCF-S 242 + + + + + D L ++ E II + + Sbjct: 289 FIIGVLPILSNSQMFLVLS-DQTLQLINVEEDLKNDEDTIQVTSSIAGNHGIIADMRYVG 347 Query: 243 PNRYWLCAATG-PSIKIW---DLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTL 298 P L AT PS++I DL G L E+ + SL + DG + Sbjct: 348 PELNKLALATNSPSLRIIPVPDLSGPEASLPLDVEIY----EGHEDLLNSLDATEDGLWI 403 Query: 299 FAGYTDNLVRVWQVTIGT 316 DN VW+ + Sbjct: 404 ATASKDNTAIVWRYNENS 421 Score = 72.0 bits (175), Expect = 3e-13, Method: Composition-based stats. Identities = 37/231 (16%), Positives = 86/231 (37%), Gaps = 21/231 (9%) Query: 93 TTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVS 152 G + + V +V S + + + + D+ I + + + + S+ + Sbjct: 7 YKGISLNPIYAGSSAVATV--SENGKILATPVLDE-INIIDLTPGSRKILHKISNEDEQE 63 Query: 153 CVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGK 212 + +L+K+++L K+ + + + +L A GG Sbjct: 64 ITALKLTPDGQYLTYVSQAQLLKIFHLKTGKVVRSMKI-SSPSYILDADSTSTLLAVGGT 122 Query: 213 DGQAMLWDLNEGKHLYTLDGGD-IINALCFS---PNRYWLCAATGPS--IKIWDLEGKII 266 DG ++ D+ G ++ G I++L F ++ WL A+ + +K+WDL + Sbjct: 123 DGSIIVVDIENGYITHSFKGHGGTISSLKFYGQLNSKIWLLASGDTNGMVKVWDLVKRKC 182 Query: 267 VDELKQEVIST----SSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVT 313 + L++ + + SL L +G D+++ +W Sbjct: 183 LHTLQEHTSAVRGLDIIEVPDNDEPSLN-------LLSGGRDDIINLWDFN 226 Score = 30.0 bits (66), Expect = 1.2, Method: Composition-based stats. Identities = 16/75 (21%), Positives = 29/75 (38%), Gaps = 6/75 (8%) Query: 242 SPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAG 301 S N L I I DL ++++ S + + T+L + DGQ L Sbjct: 26 SENGKILATPVLDEINIIDLTPGS------RKILHKISNEDEQEITALKLTPDGQYLTYV 79 Query: 302 YTDNLVRVWQVTIGT 316 L++++ + G Sbjct: 80 SQAQLLKIFHLKTGK 94 >3FM0-A nrPDB Length = 345 Score = 175 bits (443), Expect = 3e-44, Method: Composition-based stats. Identities = 67/338 (19%), Positives = 121/338 (35%), Gaps = 33/338 (9%) Query: 1 MTEQMTLRGTLKGH-NGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRAL 59 M + + L G + H + +A P ++ S D+ I +W E + I + L Sbjct: 1 MKDSLVLLGRVPAHPDSRCWFLAWNPA-GTLLASCGGDRRIRIWG---TEGDSWICKSVL 56 Query: 60 -RGHSHFVSDVVISSDGQFALSGSWDGTLRLW--DLTTGTTTRRFVGHTKDVLSVAFSSD 116 GH V V S G + S S+D T +W + GH +V SVA++ Sbjct: 57 SEGHQRTVRKVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPS 116 Query: 117 NRQIVSGSRDKTIKLW--NTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLV 174 + + SRDK++ +W + + SH++ V V + P S ++ S +D V Sbjct: 117 GNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHP--SQELLASASYDDTV 174 Query: 175 KVWNLANCKLK--TNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDL----------- 221 K++ GH + ++ P G AS D +W Sbjct: 175 KLYREEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVAC 234 Query: 222 ----NEGKHLYTLDG--GDIINALCFSP-NRYWLCAATGPSIKIWDLEGKIIVDELKQEV 274 K + TL G I + + A +I+++ + + + Sbjct: 235 SGSDPSWKCICTLSGFHSRTIYDIAWCQLTGALATACGDDAIRVFQEDPNSDPQQPTFSL 294 Query: 275 ISTSSKAEPPQCTSLAWSA-DGQTLFAGYTDNLVRVWQ 311 + +A +AW+ + L + D V W+ Sbjct: 295 TAHLHQAHSQDVNCVAWNPKEPGLLASCSDDGEVAFWK 332 Score = 144 bits (363), Expect = 5e-35, Method: Composition-based stats. Identities = 52/242 (21%), Positives = 96/242 (39%), Gaps = 34/242 (14%) Query: 9 GTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSD 68 TL+GH V +A P +++ + SRDK++ +W++ DE + L H+ V Sbjct: 99 TTLEGHENEVKSVAWAP-SGNLLATCSRDKSVWVWEV--DEEDEYECVSVLNSHTQDVKH 155 Query: 69 VVISSDGQFALSGSWDGTLRLW--DLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRD 126 VV + S S+D T++L+ + GH V S+AF +++ S S D Sbjct: 156 VVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDD 215 Query: 127 KTIKLW----------------NTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGW 170 +T+++W + C T+ HS + + + + + Sbjct: 216 RTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGF-HSRTIYDIAW--CQLTGALATACG 272 Query: 171 DKLVKVW--NLANCKLKTN-------HIGHTGYLNTVTVSPDGS-LCASGGKDGQAMLWD 220 D ++V+ + + + H H+ +N V +P L AS DG+ W Sbjct: 273 DDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPKEPGLLASCSDDGEVAFWK 332 Query: 221 LN 222 Sbjct: 333 YQ 334 Score = 92.1 bits (227), Expect = 3e-19, Method: Composition-based stats. Identities = 31/165 (18%), Positives = 67/165 (40%), Gaps = 13/165 (7%) Query: 159 NSSNPIIVSCGWDKLVKVWNLANCKLKTNH---IGHTGYLNTVTVSPDGSLCASGGKDGQ 215 N + ++ SCG D+ +++W GH + V SP G+ AS D Sbjct: 25 NPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASFDAT 84 Query: 216 AMLWDLN--EGKHLYTLDGGD-IINALCFSPNRYWLCAAT-GPSIKIWDLEGKIIVDELK 271 +W N + + + TL+G + + ++ ++P+ L + S+ +W+ VDE Sbjct: 85 TCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWE------VDEED 138 Query: 272 QEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGT 316 + + + + W + L + D+ V++++ Sbjct: 139 EYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDD 183 Score = 73.2 bits (178), Expect = 2e-13, Method: Composition-based stats. Identities = 26/128 (20%), Positives = 46/128 (35%), Gaps = 12/128 (9%) Query: 192 TGYLNTVTVSPDGSLCASGGKDGQAMLWDLNE----GKHLYTLDGGDIINALCFSPNRYW 247 + +P G+L AS G D + +W K + + + + +SP + Sbjct: 16 DSRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNY 75 Query: 248 LCAAT-GPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNL 306 L +A+ + IW T+ + + S+AW+ G L D Sbjct: 76 LASASFDATTCIWKKNQDDF-------ECVTTLEGHENEVKSVAWAPSGNLLATCSRDKS 128 Query: 307 VRVWQVTI 314 V VW+V Sbjct: 129 VWVWEVDE 136 >4J0W-A nrPDB Length = 343 Score = 174 bits (442), Expect = 4e-44, Method: Composition-based stats. Identities = 63/274 (22%), Positives = 107/274 (39%), Gaps = 16/274 (5%) Query: 57 RALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFV-----------GHT 105 R LRGH ++ +V++ D S + D ++ W + +G GH+ Sbjct: 8 RVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHS 67 Query: 106 KDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPII 165 VL +A SSD + + SG R K I +W C++ H + VS + F + + Sbjct: 68 SHVLCMAISSDGKYLASGDRSKLILIWEAQS-CQHLYTFTGHRDAVSGLAFRRGTHQ--L 124 Query: 166 VSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGK 225 S D+ VKVWN+A GH + + +GG+DG +W + E Sbjct: 125 YSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEES 184 Query: 226 HLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKII--VDELKQEVISTSSKAEP 283 L I+ + + + A S+ +W L K + + +P Sbjct: 185 QLVFYGHQGSIDCIHLINEEHMVSGADDGSVALWGLSKKRPLALQREAHGLRGEPGLEQP 244 Query: 284 PQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGTR 317 +S+A + + G + VR+WQ G R Sbjct: 245 FWISSVAALLNTDLVATGSHSSCVRLWQCGEGFR 278 Score = 173 bits (438), Expect = 9e-44, Method: Composition-based stats. Identities = 74/329 (22%), Positives = 131/329 (39%), Gaps = 33/329 (10%) Query: 9 GTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALR------GH 62 L+GH +T + TP I SA++D +II W + + IP+ GH Sbjct: 8 RVLRGHQLSITCLVVTPDDS-AIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGH 66 Query: 63 SHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVS 122 S V + ISSDG++ SG + +W+ + F GH V +AF Q+ S Sbjct: 67 SSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYS 126 Query: 123 GSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANC 182 S D+++K+WN Y H + V+ S + + G D V+VW + Sbjct: 127 TSHDRSVKVWNV-AENSYVETLFGHQDAVA--ALDALSRECCVTAGGRDGTVRVWKIPE- 182 Query: 183 KLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYT------------L 230 + + GH G ++ + + + + SG DG LW L++ + L L Sbjct: 183 ESQLVFYGHQGSIDCIHLINEEHM-VSGADDGSVALWGLSKKRPLALQREAHGLRGEPGL 241 Query: 231 DGGDIINALCFSPNRYWLCAATGPSI-KIWDLEGKIIVDELKQEVISTSSKAEPPQCTSL 289 + I+++ N + + S ++W +++ SL Sbjct: 242 EQPFWISSVAALLNTDLVATGSHSSCVRLWQCGEGF------RQLDLLCDIPLVGFINSL 295 Query: 290 AWSADGQTLFAG-YTDNLV-RVWQVTIGT 316 +S+ G L AG ++ + R W++ Sbjct: 296 KFSSSGDFLVAGVGQEHRLGRWWRIKEAR 324 Score = 60.5 bits (145), Expect = 1e-09, Method: Composition-based stats. Identities = 25/145 (17%), Positives = 47/145 (32%), Gaps = 22/145 (15%) Query: 185 KTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLD------------G 232 GH + + V+PD S S KD + W + G+ L+ + Sbjct: 7 IRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGH 66 Query: 233 GDIINALCFSPNRYWLCAAT-GPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAW 291 + + S + +L + I IW+ + + + LA+ Sbjct: 67 SSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTF---------TGHRDAVSGLAF 117 Query: 292 SADGQTLFAGYTDNLVRVWQVTIGT 316 L++ D V+VW V + Sbjct: 118 RRGTHQLYSTSHDRSVKVWNVAENS 142 >6Q8F-A nrPDB Length = 514 Score = 171 bits (434), Expect = 3e-43, Method: Composition-based stats. Identities = 65/296 (21%), Positives = 126/296 (42%), Gaps = 26/296 (8%) Query: 38 KTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTT 97 + + ++ + + G V S DGQ+ ++GS DG + +W+ TTG Sbjct: 190 GKAAVKDVEEEKFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKI 249 Query: 98 TRRFVGHTKD--------VLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSE 149 + +D VL + FS D + +G++D IK+W + +HS+ Sbjct: 250 RKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSK 309 Query: 150 WVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCAS 209 V+C+ FS +SS I+S +D+ +++ L + K GH+ ++N T + DG S Sbjct: 310 GVTCLSFSKDSSQ--ILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIIS 367 Query: 210 GGKDGQAMLWDLNEGKHLYTLD------GGDI-INALCFSPN--RYWLCAATGPSIKIWD 260 DG +W++ + T G DI +N++ P +++ ++ I + Sbjct: 368 ASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMN 427 Query: 261 LEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGT 316 ++G+I+ +S K E A S G+ ++ D ++ + G Sbjct: 428 MQGQIV-------RSFSSGKREGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGK 476 Score = 145 bits (366), Expect = 2e-35, Method: Composition-based stats. Identities = 59/254 (23%), Positives = 106/254 (41%), Gaps = 15/254 (5%) Query: 15 NGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSD 74 + V + + + +M+ + ++D I +WK+ + +R R HS V+ + S D Sbjct: 265 DDAVLCMCFS-RDTEMLATGAQDGKIKVWKIQSGQC----LRRFERAHSKGVTCLSFSKD 319 Query: 75 GQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWN- 133 LS S+D T+R+ L +G T + F GH+ V F+ D I+S S D T+K+WN Sbjct: 320 SSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNM 379 Query: 134 TLGVCKYTVQDESHSE----WVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHI 189 C T + + V+ V P + +V C V + N+ +++ Sbjct: 380 KTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVV-CNRSNTVVIMNMQGQIVRSFSS 438 Query: 190 G--HTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGD-IINALCFSPNRY 246 G G +SP G G+D + GK TL + + + P++ Sbjct: 439 GKREGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQN 498 Query: 247 WLCA-ATGPSIKIW 259 + + +K+W Sbjct: 499 LIATYSEDGLLKLW 512 Score = 134 bits (337), Expect = 6e-32, Method: Composition-based stats. Identities = 56/222 (25%), Positives = 89/222 (40%), Gaps = 16/222 (7%) Query: 7 LRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFV 66 LR + H+ VT ++ + ILSAS D+TI + G + RGHS FV Sbjct: 300 LRRFERAHSKGVTCLSFSKD-SSQILSASFDQTIRI-----HGLKSGKTLKEFRGHSSFV 353 Query: 67 SDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFV------GHTKDVLSVAFSSDN-RQ 119 ++ + DG + +S S DGT+++W++ T + F G V SV N Sbjct: 354 NEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEH 413 Query: 120 IVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVS-CVRFSPNSSNPIIVSCGWDKLVKVWN 178 V +R T+ + N G + C SP I G D ++ ++ Sbjct: 414 FVVCNRSNTVVIMNMQGQIVRSFSSGKREGGDFVCCALSP--RGEWIYCVGEDFVLYCFS 471 Query: 179 LANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWD 220 KL+ H + + P +L A+ +DG LW Sbjct: 472 TVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLWK 513 Score = 38.5 bits (88), Expect = 0.003, Method: Composition-based stats. Identities = 13/39 (33%), Positives = 18/39 (46%), Gaps = 1/39 (2%) Query: 6 TLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWK 44 L TL H V IA P ++I + S D + +WK Sbjct: 476 KLERTLTVHEKDVIGIAHHPHQ-NLIATYSEDGLLKLWK 513 >3MKQ-A nrPDB Length = 814 Score = 171 bits (432), Expect = 5e-43, Method: Composition-based stats. Identities = 62/308 (20%), Positives = 113/308 (36%), Gaps = 23/308 (7%) Query: 5 MTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSH 64 + ++ T + V I P P +L+ + +W + R+++ Sbjct: 3 LDIKKTFSNRSDRVKGIDFHPTEP-WVLTTLYSGRVEIWNYETQ-----VEVRSIQVTET 56 Query: 65 FVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGS 124 V + + + GS D +R+++ TG F H + S+A ++SGS Sbjct: 57 PVRAGKFIARKNWIIVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGS 116 Query: 125 RDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKL 184 D T+KLWN E H +V CV F+P + S D+ VKVW+L Sbjct: 117 DDLTVKLWNWENNWALEQTFEGHEHFVMCVAFNPKDPS-TFASGCLDRTVKVWSLGQSTP 175 Query: 185 KTNH-IGHTGYLNTVTV--SPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGG-DIINALC 240 G +N V PD + D +WD + TL+G ++ Sbjct: 176 NFTLTTGQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAV 235 Query: 241 FSPNRYWLCAAT-GPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQ--T 297 F P + + + ++KIW+ + L + + +A G+ Sbjct: 236 FHPTLPIIISGSEDGTLKIWNSSTYKVEKTLNVGLERS---------WCIATHPTGRKNY 286 Query: 298 LFAGYTDN 305 + +G+ + Sbjct: 287 IASGFDNG 294 Score = 166 bits (421), Expect = 9e-42, Method: Composition-based stats. Identities = 72/357 (20%), Positives = 121/357 (33%), Gaps = 67/357 (18%) Query: 4 QMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHS 63 L T +GH +V +A P+ P S D+T+ +W L + N+ + RG + Sbjct: 129 NWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQERGVN 188 Query: 64 HFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSG 123 + D D + ++ S D T+++WD T + GH +V F I+SG Sbjct: 189 YV--DYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAVFHPTLPIIISG 246 Query: 124 SRDKTIKLWNTLG-VCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANC 182 S D T+K+WN+ + T+ W C+ P I S G+D V +L N Sbjct: 247 SEDGTLKIWNSSTYKVEKTLNVGLERSW--CIATHPTGRKNYIAS-GFDNGFTVLSLGND 303 Query: 183 KLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDII------ 236 + T+++ P G L SGGK+ A + G + + Sbjct: 304 EP------------TLSLDPVGKLVWSGGKNAAA------SDIFTAVIRGNEEVEQDEPL 345 Query: 237 --------------NALCFSPNRYWLCAATGP------------------SIKIWDLEGK 264 +L SPN ++ +W + Sbjct: 346 SLQTKELGSVDVFPQSLAHSPNGRFVTVVGDGEYVIYTALAWRNKAFGKCQDFVWGPDSN 405 Query: 265 IIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGY-----TDNLVRVWQVTIGT 316 + I + S+ + LF+G +D V + GT Sbjct: 406 SYALIDETGQIKYYKNFKEVTSWSVPMHSAIDRLFSGALLGVKSDGFVYFFDWDNGT 462 Score = 160 bits (404), Expect = 8e-40, Method: Composition-based stats. Identities = 50/249 (20%), Positives = 91/249 (36%), Gaps = 10/249 (4%) Query: 29 DMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLR 88 + I+ S D I ++ E H ++ + + + LSGS D T++ Sbjct: 68 NWIIVGSDDFRIRVFNYNTGEKVVD-----FEAHPDYIRSIAVHPTKPYVLSGSDDLTVK 122 Query: 89 LWDLTTG-TTTRRFVGHTKDVLSVAFSS-DNRQIVSGSRDKTIKLWNTLGVCKYTVQDES 146 LW+ + F GH V+ VAF+ D SG D+T+K+W+ Sbjct: 123 LWNWENNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTG 182 Query: 147 HSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSL 206 V+ V + P P +++ D +K+W+ GH ++ P + Sbjct: 183 QERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAVFHPTLPI 242 Query: 207 CASGGKDGQAMLWDLNEGKHLYTLDGGDIIN-ALCFSPNR--YWLCAATGPSIKIWDLEG 263 SG +DG +W+ + K TL+ G + + P ++ + + L Sbjct: 243 IISGSEDGTLKIWNSSTYKVEKTLNVGLERSWCIATHPTGRKNYIASGFDNGFTVLSLGN 302 Query: 264 KIIVDELKQ 272 L Sbjct: 303 DEPTLSLDP 311 Score = 67.4 bits (163), Expect = 7e-12, Method: Composition-based stats. Identities = 17/129 (13%), Positives = 43/129 (33%), Gaps = 11/129 (8%) Query: 185 KTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGD-IINALCFSP 243 K + + + P + G+ +W+ + ++ + + A F Sbjct: 6 KKTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVEIWNYETQVEVRSIQVTETPVRAGKFIA 65 Query: 244 NRYWLCAATGP-SIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGY 302 + W+ + I++++ V + + A P S+A + +G Sbjct: 66 RKNWIIVGSDDFRIRVFNYNTGEKVVDFE---------AHPDYIRSIAVHPTKPYVLSGS 116 Query: 303 TDNLVRVWQ 311 D V++W Sbjct: 117 DDLTVKLWN 125 Score = 37.4 bits (85), Expect = 0.009, Method: Composition-based stats. Identities = 14/85 (16%), Positives = 30/85 (35%), Gaps = 10/85 (11%) Query: 234 DIINALCFSPNRYWLCAA-TGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWS 292 D + + F P W+ ++IW+ E ++ V ++ + + Sbjct: 14 DRVKGIDFHPTEPWVLTTLYSGRVEIWNYETQVEVRSIQVTETP---------VRAGKFI 64 Query: 293 ADGQTLFAGYTDNLVRVWQVTIGTR 317 A + G D +RV+ G + Sbjct: 65 ARKNWIIVGSDDFRIRVFNYNTGEK 89 >5K1B-B nrPDB Length = 677 Score = 170 bits (430), Expect = 7e-43, Method: Composition-based stats. Identities = 53/226 (23%), Positives = 97/226 (42%), Gaps = 9/226 (3%) Query: 16 GWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDG 75 V + P + + +A RD I +W + + + + I ++ H+ +V+D+V+ +G Sbjct: 31 NGVNALQLDPAL-NRLFTAGRDSIIRIWSVNQHKQDPYIA--SMEHHTDWVNDIVLCCNG 87 Query: 76 QFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNT- 134 + +S S D T+++W+ G H V ++A++ D + S D+ I LW+ Sbjct: 88 KTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVN 147 Query: 135 -----LGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHI 189 S + N IIVS +K+++VW+ C Sbjct: 148 TLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLK 207 Query: 190 GHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDI 235 GHT + + ++ DG+ C SG DG LW L + + + T D Sbjct: 208 GHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDE 253 Score = 128 bits (322), Expect = 3e-30, Method: Composition-based stats. Identities = 43/259 (16%), Positives = 100/259 (38%), Gaps = 28/259 (10%) Query: 65 FVSDVVISSDGQFALSGSWDGTLRLWDLTTGTT---TRRFVGHTKDVLSVAFSSDNRQIV 121 V+ + + + D +R+W + HT V + + + ++ Sbjct: 32 GVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKTLI 91 Query: 122 SGSRDKTIKLWNT-LGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLA 180 S S D T+K+WN G C T++ H ++V + ++ + ++ S G D+ + +W++ Sbjct: 92 SASSDTTVKVWNAHKGFCMSTLRT--HKDYVKALAYAKD--KELVASAGLDRQIFLWDVN 147 Query: 181 NCKLKT---------NHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLD 231 T + G+ + ++ ++ G++ SG + +WD L L Sbjct: 148 TLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLK 207 Query: 232 GG-DIINALCFSPNRYW-LCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSL 289 G D + AL + + L ++ +I++W L + + + +L Sbjct: 208 GHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRV---------HDEGVWAL 258 Query: 290 AWSADGQTLFAGYTDNLVR 308 + +++G D + Sbjct: 259 QVNDAFTHVYSGGRDRKIY 277 Score = 126 bits (316), Expect = 1e-29, Method: Composition-based stats. Identities = 49/225 (21%), Positives = 88/225 (39%), Gaps = 24/225 (10%) Query: 102 VGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCK--YTVQDESHSEWVSCVRFSPN 159 + V ++ ++ + RD I++W+ + Y E H++WV+ + N Sbjct: 27 KYNRNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCN 86 Query: 160 SSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLW 219 ++S D VKVWN + H Y+ + + D L AS G D Q LW Sbjct: 87 G--KTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLW 144 Query: 220 DLNEGKHL---------YTLDGG-DIINALCFSPNRYWLCA-ATGPSIKIWDLEGKIIVD 268 D+N L +L G D I +L + + + +T +++WD + Sbjct: 145 DVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLM 204 Query: 269 ELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVT 313 +LK +L + DG +G +D +R+W + Sbjct: 205 KLK---------GHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLG 240 Score = 115 bits (289), Expect = 2e-26, Method: Composition-based stats. Identities = 62/291 (21%), Positives = 112/291 (38%), Gaps = 34/291 (11%) Query: 10 TLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTR----DETNYGIPQRALRGHSHF 65 TL+ H +V +A +++ SA D+ I +W + +N + +L G+ Sbjct: 112 TLRTHKDYVKALAYAKD-KELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDS 170 Query: 66 VSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSR 125 + + ++ G +SGS + LR+WD T + GHT +V ++ + D Q +SGS Sbjct: 171 IYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSS 230 Query: 126 DKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLK 185 D TI+LW +LG + H E V ++ N + + S G D+ + +L N ++ Sbjct: 231 DGTIRLW-SLGQQRCIATYRVHDEGVWALQV--NDAFTHVYSGGRDRKIYCTDLRNPDIR 287 Query: 186 TNHIGHTGYLNTVTVSPD------------------------GSLCASGGKDGQAM--LW 219 + + + + ASG D + Sbjct: 288 VLICEEKAPVLKMELDRSADPPPAIWVATTKSTVNKWTLKGIHNFRASGDYDNDCTNPIT 347 Query: 220 DLNEGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDEL 270 L G II + R+ L T ++ WD+ V++L Sbjct: 348 PLCTQPDQVIKGGASIIQCHILNDKRHILTKDTNNNVAYWDVLKACKVEDL 398 Score = 103 bits (257), Expect = 9e-23, Method: Composition-based stats. Identities = 34/172 (19%), Positives = 75/172 (43%), Gaps = 7/172 (4%) Query: 148 SEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKL---KTNHIGHTGYLNTVTVSPDG 204 V+ ++ P + + + G D ++++W++ K + HT ++N + + +G Sbjct: 30 RNGVNALQLDP--ALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNG 87 Query: 205 SLCASGGKDGQAMLWDLNEGKHLYTLDGG-DIINALCFSPNRYWLCAAT-GPSIKIWDLE 262 S D +W+ ++G + TL D + AL ++ ++ + +A I +WD+ Sbjct: 88 KTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVN 147 Query: 263 GKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTI 314 + V ++S SLA + G + +G T+ ++RVW Sbjct: 148 TLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRT 199 Score = 49.3 bits (116), Expect = 2e-06, Method: Composition-based stats. Identities = 20/84 (23%), Positives = 33/84 (39%), Gaps = 7/84 (8%) Query: 234 DIINALCFSPN-RYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWS 292 + +NAL P A I+IW V++ KQ+ S + + Sbjct: 31 NGVNALQLDPALNRLFTAGRDSIIRIWS------VNQHKQDPYIASMEHHTDWVNDIVLC 84 Query: 293 ADGQTLFAGYTDNLVRVWQVTIGT 316 +G+TL + +D V+VW G Sbjct: 85 CNGKTLISASSDTTVKVWNAHKGF 108 >4YCZ-A nrPDB Length = 876 Score = 169 bits (429), Expect = 1e-42, Method: Composition-based stats. Identities = 68/335 (20%), Positives = 120/335 (35%), Gaps = 54/335 (16%) Query: 3 EQMTLRGTLKGHNGWVTQIAT-TPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRG 61 E L TLKGH+G V ++ P++ +++ SA D +++W G QR Sbjct: 50 ETQRLTETLKGHDGAVWCVSWAHPKYGNILASAGYDGKVLIW-----RELNGAWQRIFDF 104 Query: 62 --HSHFVSDVVISSD--GQFALSGSWDGTLRLWDLTTGTTTRR-FVGHTKDVLSVAFSS- 115 H V+ V S G S DG + + + + F H V SV+++ Sbjct: 105 ALHKASVNVVSWSPHEAGCLLACASSDGNVSVLEFRDNSWEHSIFHAHGLGVNSVSWAPA 164 Query: 116 ----------------DNRQIVSGSRDKTIKLWN----TLGVCKYTVQDESHSEWVSCVR 155 NR+ V+G D +K+W T H++WV V Sbjct: 165 TSPGSIVSSKPGPKSTGNRRFVTGGSDNALKIWAYDPATNTYKLEREPLTGHTDWVRDVA 224 Query: 156 FSPNSSNP-IIVSCGWDKLVKVWN---LANCKLKTNHIGHTGYLNTVTVSPDGSLCASGG 211 +SP I S D+ V++W + + + V+ S G++ A+ G Sbjct: 225 WSPTVLQKSYIASASEDRTVRIWTSDPANPLQWNCKVLNFDAAVWRVSWSLSGNVLAASG 284 Query: 212 KDGQAMLWDLN---EGKHLYTLDGGDIINAL---CFSPNRYWLCAATGPSIKIWDLEGKI 265 D + LW N E + + T++ G + P + + +K W + + Sbjct: 285 GDNKVTLWKENLKGEWECVKTIEEGGGGSGGGGQAKGPTQPEQASPAKGFVK-WPYQQRP 343 Query: 266 IVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFA 300 +D+ + P W +G + Sbjct: 344 KIDQQEG-----------PSIPRTNWGPNGLLVTT 367 Score = 152 bits (384), Expect = 2e-37, Method: Composition-based stats. Identities = 53/284 (18%), Positives = 102/284 (35%), Gaps = 39/284 (13%) Query: 61 GHSHFVSDVVISSDGQFALSGSWDGTLRLWDLT--TGTTTRRFVGHTKDVLSVAFS--SD 116 GH + D V+ G+ + S D T++++++ T T GH V V+++ Sbjct: 16 GHDDMIHDAVLDYYGRRLATCSSDRTIKIFEIEGETQRLTETLKGHDGAVWCVSWAHPKY 75 Query: 117 NRQIVSGSRDKTIKLW-NTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVK 175 + S D + +W G + H V+ V +SP+ + ++ D V Sbjct: 76 GNILASAGYDGKVLIWRELNGAWQRIFDFALHKASVNVVSWSPHEAGCLLACASSDGNVS 135 Query: 176 VWNLANCKLK-TNHIGHTGYLNTVTVSPDGS-----------------LCASGGKDGQAM 217 V + + + H +N+V+ +P S +GG D Sbjct: 136 VLEFRDNSWEHSIFHAHGLGVNSVSWAPATSPGSIVSSKPGPKSTGNRRFVTGGSDNALK 195 Query: 218 LWDLNEGKHLYTLD------GGDIINALCFSPN----RYWLCAATGPSIKIWDLEGKIIV 267 +W + + Y L+ D + + +SP Y A+ +++IW + + Sbjct: 196 IWAYDPATNTYKLEREPLTGHTDWVRDVAWSPTVLQKSYIASASEDRTVRIWTSDPANPL 255 Query: 268 DELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQ 311 + ++WS G L A DN V +W+ Sbjct: 256 Q------WNCKVLNFDAAVWRVSWSLSGNVLAASGGDNKVTLWK 293 Score = 137 bits (345), Expect = 7e-33, Method: Composition-based stats. Identities = 56/281 (19%), Positives = 100/281 (35%), Gaps = 38/281 (13%) Query: 13 GHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVIS 72 GH+ + + + + S D+TI ++++ E L+GH V V + Sbjct: 16 GHDDMIHDAVLD-YYGRRLATCSSDRTIKIFEI---EGETQRLTETLKGHDGAVWCVSWA 71 Query: 73 SD--GQFALSGSWDGTLRLWDLTTGTTTR--RFVGHTKDVLSVAFSSD--NRQIVSGSRD 126 G S +DG + +W G R F H V V++S + S D Sbjct: 72 HPKYGNILASAGYDGKVLIWRELNGAWQRIFDFALHKASVNVVSWSPHEAGCLLACASSD 131 Query: 127 KTIKLWNTLGVCKYTVQDESHSEWVSCVRFSP---------------NSSNPIIVSCGWD 171 + + +H V+ V ++P ++ N V+ G D Sbjct: 132 GNVSVLEFRDNSWEHSIFHAHGLGVNSVSWAPATSPGSIVSSKPGPKSTGNRRFVTGGSD 191 Query: 172 KLVKVW--NLANCKLKTN---HIGHTGYLNTVTVSP---DGSLCASGGKDGQAMLWDLNE 223 +K+W + A K GHT ++ V SP S AS +D +W + Sbjct: 192 NALKIWAYDPATNTYKLEREPLTGHTDWVRDVAWSPTVLQKSYIASASEDRTVRIWTSDP 251 Query: 224 GKHLY----TLDGGDIINALCFSPNRYWLCAATGPS-IKIW 259 L L+ + + +S + L A+ G + + +W Sbjct: 252 ANPLQWNCKVLNFDAAVWRVSWSLSGNVLAASGGDNKVTLW 292 Score = 92.1 bits (227), Expect = 3e-19, Method: Composition-based stats. Identities = 32/203 (15%), Positives = 71/203 (34%), Gaps = 37/203 (18%) Query: 135 LGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLA--NCKLKTNHIGHT 192 + + + H + + + + +C D+ +K++ + +L GH Sbjct: 5 MAAGTQVIANSGHDDMIHDAVL--DYYGRRLATCSSDRTIKIFEIEGETQRLTETLKGHD 62 Query: 193 GYLNTVTV-SPD-GSLCASGGKDGQAMLWDLNEGKHLYTLD---GGDIINALCFSPNRY- 246 G + V+ P G++ AS G DG+ ++W G D +N + +SP+ Sbjct: 63 GAVWCVSWAHPKYGNILASAGYDGKVLIWRELNGAWQRIFDFALHKASVNVVSWSPHEAG 122 Query: 247 --WLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAW------------- 291 CA++ ++ + + + A S++W Sbjct: 123 CLLACASSDGNVSVLEFRDNSWEHSI--------FHAHGLGVNSVSWAPATSPGSIVSSK 174 Query: 292 ----SADGQTLFAGYTDNLVRVW 310 S + G +DN +++W Sbjct: 175 PGPKSTGNRRFVTGGSDNALKIW 197 Score = 49.7 bits (117), Expect = 2e-06, Method: Composition-based stats. Identities = 18/100 (18%), Positives = 40/100 (40%), Gaps = 11/100 (11%) Query: 221 LNEGKHLYTLDGGDII--NALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTS 278 + G + G D + +A+ R ++ +IKI+++EG + + ++ + Sbjct: 5 MAAGTQVIANSGHDDMIHDAVLDYYGRRLATCSSDRTIKIFEIEG-------ETQRLTET 57 Query: 279 SKAEPPQCTSLAWS--ADGQTLFAGYTDNLVRVWQVTIGT 316 K ++W+ G L + D V +W+ G Sbjct: 58 LKGHDGAVWCVSWAHPKYGNILASAGYDGKVLIWRELNGA 97 >3CFV-B nrPDB Length = 414 Score = 168 bits (426), Expect = 3e-42, Method: Composition-based stats. Identities = 74/291 (25%), Positives = 127/291 (43%), Gaps = 36/291 (12%) Query: 14 HNGWVTQIATTPQFPDMILSASRDKTIIMWKLTR-----DETNYGIPQRALRGHSHFVSD 68 H G V + PQ P +I + + ++++ T+ D + P LRGH Sbjct: 125 HEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGYG 184 Query: 69 VVISSD-GQFALSGSWDGTLRLWDLTTGTTTRR-------FVGHTKDVLSVAFSSDNRQI 120 + +S+ LS S D T+ LWD+ G + F GH+ V VA+ + + Sbjct: 185 LSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESL 244 Query: 121 V-SGSRDKTIKLWNTLG--VCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVW 177 S + D+ + +W+T K + ++H+ V+C+ F+P S I+ + DK V +W Sbjct: 245 FGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNP-YSEFILATGSADKTVALW 303 Query: 178 NLANCKLKT-NHIGHTGYLNTVTVSP-DGSLCASGGKDGQAMLWDLNE-GKHLYTLDGGD 234 +L N KLK H + V SP + ++ AS G D + +WDL++ G+ D D Sbjct: 304 DLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAED 363 Query: 235 I--------------INALCFSPNRYWLCA--ATGPSIKIWDLEGKIIVDE 269 I+ ++PN W+ + ++IW + I DE Sbjct: 364 GPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMAENIYNDE 414 Score = 157 bits (398), Expect = 4e-39, Method: Composition-based stats. Identities = 59/236 (25%), Positives = 101/236 (42%), Gaps = 23/236 (9%) Query: 11 LKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLT--RDETNYGIPQRALRGHSHFVSD 68 L+GH ++ +LSAS D T+ +W + E + GHS V D Sbjct: 175 LRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVED 234 Query: 69 VVISS-DGQFALSGSWDGTLRLWDLTTGTTTRR---FVGHTKDVLSVAFSSDNRQIV-SG 123 V S + D L +WD + TT++ HT +V ++F+ + I+ +G Sbjct: 235 VAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATG 294 Query: 124 SRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLA--- 180 S DKT+ LW+ + ESH + + V +SP++ I+ S G D+ + VW+L+ Sbjct: 295 SADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNET-ILASSGTDRRLNVWDLSKIG 353 Query: 181 -----------NCKLKTNHIGHTGYLNTVTVSPDGSLCA-SGGKDGQAMLWDLNEG 224 +L H GHT ++ + +P+ S +D +W + E Sbjct: 354 EEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMAEN 409 Score = 107 bits (266), Expect = 8e-24, Method: Composition-based stats. Identities = 37/189 (19%), Positives = 75/189 (39%), Gaps = 19/189 (10%) Query: 5 MTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSH 64 + + GH+ V +A + S + D+ +++W + T+ P + H+ Sbjct: 219 VDAKAIFTGHSAVVEDVAWHLLHESLFGSVADDQKLMIWDTRSNTTS--KPSHLVDAHTA 276 Query: 65 FVSDVVISSDGQF-ALSGSWDGTLRLWDLTTGT-TTRRFVGHTKDVLSVAFSSDNR-QIV 121 V+ + + +F +GS D T+ LWDL F H ++ V +S N + Sbjct: 277 EVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILA 336 Query: 122 SGSRDKTIKLWNTL-------------GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSC 168 S D+ + +W+ G + H+ +S ++PN +I S Sbjct: 337 SSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEP-WVICSV 395 Query: 169 GWDKLVKVW 177 D ++++W Sbjct: 396 SEDNIMQIW 404 Score = 100 bits (249), Expect = 9e-22, Method: Composition-based stats. Identities = 44/238 (18%), Positives = 89/238 (37%), Gaps = 34/238 (14%) Query: 102 VGHTKDVLSVAFSSDNRQIV---SGSRDKTIKLW-------NTLGVCKYTVQDESHSEWV 151 + H +V + N I+ + S D + + + G C ++ H + Sbjct: 123 INHEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEG 182 Query: 152 SCVRFSPNSSNPIIVSCGWDKLVKVWNLANCK-------LKTNHIGHTGYLNTVTVSP-D 203 + ++ N S ++ S D V +W++ K GH+ + V Sbjct: 183 YGLSWNSNLSGHLL-SASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLH 241 Query: 204 GSLCASGGKDGQAMLWDLNEG---KHLYTLDGGD-IINALCFSPNRYWLCA--ATGPSIK 257 SL S D + M+WD K + +D +N L F+P ++ A + ++ Sbjct: 242 ESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVA 301 Query: 258 IWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQT-LFAGYTDNLVRVWQVTI 314 +WDL ++ + ++ + + WS +T L + TD + VW ++ Sbjct: 302 LWDLRN--------LKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSK 351 Score = 57.8 bits (138), Expect = 6e-09, Method: Composition-based stats. Identities = 18/105 (17%), Positives = 45/105 (42%), Gaps = 11/105 (10%) Query: 2 TEQMTLRG-TLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTR-------DETNYG 53 + L+ T + H + Q+ +P ++ S+ D+ + +W L++ ++ G Sbjct: 305 LRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDG 364 Query: 54 IPQRALR--GHSHFVSDVVISSDGQFALSG-SWDGTLRLWDLTTG 95 P+ GH+ +SD + + + + S D +++W + Sbjct: 365 PPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMAEN 409 Score = 40.1 bits (92), Expect = 0.001, Method: Composition-based stats. Identities = 14/97 (14%), Positives = 35/97 (36%), Gaps = 4/97 (4%) Query: 225 KHLYTLDGGDIINALCFSPNRYWLCAATGPS--IKIWDLEGKIIVDELKQEVISTS-SKA 281 + ++ +N + P + A PS + ++D + E + Sbjct: 118 ECEIKINHEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRG 177 Query: 282 EPPQCTSLAWSAD-GQTLFAGYTDNLVRVWQVTIGTR 317 + L+W+++ L + D+ V +W + G + Sbjct: 178 HQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPK 214 >5WJC-A nrPDB Length = 430 Score = 167 bits (424), Expect = 4e-42, Method: Composition-based stats. Identities = 55/238 (23%), Positives = 94/238 (39%), Gaps = 26/238 (10%) Query: 7 LRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKL-----TRDETNYGIPQRALRG 61 + LKGH + P P + + + D+ I +W + T ET P Sbjct: 174 PQAVLKGHTAEGFGLCWNPNLPGNLATGAEDQVICLWDVQTQSFTSSETKVISPIAKYHR 233 Query: 62 HSHFVSDVVISSDGQ-FALSGSWDGTLRLWDLTTG---TTTRRFVGHTKDVLSVAFSSDN 117 H+ V+DV + S S D TL++ D + H+K + +VA + N Sbjct: 234 HTDIVNDVQFHPQHEALLASVSDDCTLQIHDTRLNPEEEAPKVIQAHSKAINAVAINPFN 293 Query: 118 RQIV-SGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKV 176 ++ + S DKT+ LW+ + E H + V + +SP+ PI+ S D+ V + Sbjct: 294 DYLLATASADKTVALWDLRNPYQRLHTLEGHEDEVYGLEWSPH-DEPILASSSTDRRVCI 352 Query: 177 WNLA--------------NCKLKTNHIGHTGYLNTVTVSPDGSLCA-SGGKDGQAMLW 219 W+L + +L H GHT ++ + P+ S D +W Sbjct: 353 WDLEKIGEEQTPEDAEDGSPELLFMHGGHTNRISEFSWCPNERWVVGSLADDNILQIW 410 Score = 150 bits (378), Expect = 8e-37, Method: Composition-based stats. Identities = 59/283 (20%), Positives = 113/283 (39%), Gaps = 37/283 (13%) Query: 14 HNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDE---TNYGIPQRALRGHSHFVSDVV 70 H+G V + PQ P++I + ++ T + T +PQ L+GH+ + Sbjct: 130 HDGDVNRARYMPQKPEIIATMGEGGNAYIFDTTCHDALTTGEALPQAVLKGHTAEGFGLC 189 Query: 71 ISSDGQ-FALSGSWDGTLRLWDLTTG----------TTTRRFVGHTKDVLSVAFSSDNR- 118 + + +G+ D + LWD+ T + ++ HT V V F + Sbjct: 190 WNPNLPGNLATGAEDQVICLWDVQTQSFTSSETKVISPIAKYHRHTDIVNDVQFHPQHEA 249 Query: 119 QIVSGSRDKTIKLWNTLGVCKYTVQ--DESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKV 176 + S S D T+++ +T + ++HS+ ++ V +P + ++ + DK V + Sbjct: 250 LLASVSDDCTLQIHDTRLNPEEEAPKVIQAHSKAINAVAINPFND-YLLATASADKTVAL 308 Query: 177 WNLAN-CKLKTNHIGHTGYLNTVTVSP-DGSLCASGGKDGQAMLWDLNEGKHLYTLD--- 231 W+L N + GH + + SP D + AS D + +WDL + T + Sbjct: 309 WDLRNPYQRLHTLEGHEDEVYGLEWSPHDEPILASSSTDRRVCIWDLEKIGEEQTPEDAE 368 Query: 232 ------------GGDIINALCFSPNRYWLCA--ATGPSIKIWD 260 + I+ + PN W+ A ++IW Sbjct: 369 DGSPELLFMHGGHTNRISEFSWCPNERWVVGSLADDNILQIWS 411 Score = 95.5 bits (236), Expect = 2e-20, Method: Composition-based stats. Identities = 42/237 (17%), Positives = 75/237 (31%), Gaps = 35/237 (14%) Query: 104 HTKDVLSVAFSSDN-RQIVSGSRDKTIKLWNTL-------GVCKYTVQDESHSEWVSCVR 155 H DV + I + +++T G + H+ + Sbjct: 130 HDGDVNRARYMPQKPEIIATMGEGGNAYIFDTTCHDALTTGEALPQAVLKGHTAEGFGLC 189 Query: 156 FSPNSSNPIIVSCGWDKLVKVWNLANCK----------LKTNHIGHTGYLNTVTVSPDGS 205 ++PN + + D+++ +W++ + HT +N V P Sbjct: 190 WNPNLPGN-LATGAEDQVICLWDVQTQSFTSSETKVISPIAKYHRHTDIVNDVQFHPQHE 248 Query: 206 -LCASGGKDGQAMLWDLN----EGKHLYTLDGGDIINALCFSP-NRYWLCAAT-GPSIKI 258 L AS D + D E INA+ +P N Y L A+ ++ + Sbjct: 249 ALLASVSDDCTLQIHDTRLNPEEEAPKVIQAHSKAINAVAINPFNDYLLATASADKTVAL 308 Query: 259 WDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSA-DGQTLFAGYTDNLVRVWQVTI 314 WDL + + + L WS D L + TD V +W + Sbjct: 309 WDLRN--------PYQRLHTLEGHEDEVYGLEWSPHDEPILASSSTDRRVCIWDLEK 357 Score = 40.4 bits (93), Expect = 0.001, Method: Composition-based stats. Identities = 14/90 (15%), Positives = 28/90 (31%), Gaps = 4/90 (4%) Query: 228 YTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVI-STSSKAEPPQC 286 + +N + P + + A G + + E + K + Sbjct: 126 QKIPHDGDVNRARYMPQKPEIIATMGEGGNAYIFDTTCHDALTTGEALPQAVLKGHTAEG 185 Query: 287 TSLAWSAD--GQTLFAGYTDNLVRVWQVTI 314 L W+ + G L G D ++ +W V Sbjct: 186 FGLCWNPNLPGN-LATGAEDQVICLWDVQT 214 Score = 31.6 bits (70), Expect = 0.46, Method: Composition-based stats. Identities = 7/35 (20%), Positives = 17/35 (48%) Query: 13 GHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTR 47 GH +++ + P ++ S + D + +W +R Sbjct: 380 GHTNRISEFSWCPNERWVVGSLADDNILQIWSPSR 414 >3C9C-A nrPDB Length = 432 Score = 167 bits (424), Expect = 4e-42, Method: Composition-based stats. Identities = 61/243 (25%), Positives = 103/243 (42%), Gaps = 25/243 (10%) Query: 4 QMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGI--PQRALRG 61 Q LR L+GH ++ P +LSAS D TI +W + + + + G Sbjct: 174 QPDLR--LRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTG 231 Query: 62 HSHFVSDVVIS-SDGQFALSGSWDGTLRLWDLTTGTT---TRRFVGHTKDVLSVAFSSDN 117 H+ V DV S + D L +WD T + HT +V ++F+ + Sbjct: 232 HTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYS 291 Query: 118 RQI-VSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKV 176 I +GS DKT+ LW+ + ESH + + V++SP++ I+ S G D+ + V Sbjct: 292 EFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNET-ILASSGTDRRLHV 350 Query: 177 WNLA--------------NCKLKTNHIGHTGYLNTVTVSPDGSLCA-SGGKDGQAMLWDL 221 W+L+ +L H GHT ++ + +P+ S +D +W + Sbjct: 351 WDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQM 410 Query: 222 NEG 224 E Sbjct: 411 AEN 413 Score = 167 bits (423), Expect = 5e-42, Method: Composition-based stats. Identities = 71/294 (24%), Positives = 128/294 (43%), Gaps = 36/294 (12%) Query: 14 HNGWVTQIATTPQFPDMILSASRDKTIIMWKLTR-----DETNYGIPQRALRGHSHFVSD 68 H G V + PQ +I + + ++++ T+ + + P LRGH Sbjct: 129 HEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYG 188 Query: 69 VVISSD-GQFALSGSWDGTLRLWDLTTGTTTRR-------FVGHTKDVLSVAFSSDNRQI 120 + + + + LS S D T+ LWD+ R F GHT V VA+ + + Sbjct: 189 LSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESL 248 Query: 121 V-SGSRDKTIKLWNTL--GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVW 177 S + D+ + +W+T K + ++H+ V+C+ F+P S I+ + DK V +W Sbjct: 249 FGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNP-YSEFILATGSADKTVALW 307 Query: 178 NLANCKLKTN-HIGHTGYLNTVTVSP-DGSLCASGGKDGQAMLWDLNE-GKHLYTLDGGD 234 +L N KLK + H + V SP + ++ AS G D + +WDL++ G+ T D D Sbjct: 308 DLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAED 367 Query: 235 I--------------INALCFSPNRYWLCA--ATGPSIKIWDLEGKIIVDELKQ 272 I+ ++PN W+ + +++W + + DE + Sbjct: 368 GPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENVYNDEEPE 421 Score = 112 bits (280), Expect = 2e-25, Method: Composition-based stats. Identities = 39/191 (20%), Positives = 73/191 (38%), Gaps = 19/191 (9%) Query: 3 EQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGH 62 + + GH V +A + S + D+ +++W + N P + H Sbjct: 221 RVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNN--NTSKPSHTVDAH 278 Query: 63 SHFVSDVVISSDGQF-ALSGSWDGTLRLWDLTTGT-TTRRFVGHTKDVLSVAFSSDNR-Q 119 + V+ + + +F +GS D T+ LWDL F H ++ V +S N Sbjct: 279 TAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETI 338 Query: 120 IVSGSRDKTIKLWNTL-------------GVCKYTVQDESHSEWVSCVRFSPNSSNPIIV 166 + S D+ + +W+ G + H+ +S ++PN II Sbjct: 339 LASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEP-WIIC 397 Query: 167 SCGWDKLVKVW 177 S D +++VW Sbjct: 398 SVSEDNIMQVW 408 Score = 101 bits (252), Expect = 4e-22, Method: Composition-based stats. Identities = 46/238 (19%), Positives = 92/238 (38%), Gaps = 34/238 (14%) Query: 102 VGHTKDVLSVAFSSDN-RQIVSGSRDKTIKLWNTL---------GVCKYTVQDESHSEWV 151 + H +V + N I + + + +++ G C+ ++ H + Sbjct: 127 INHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEG 186 Query: 152 SCVRFSPNSSNPIIVSCGWDKLVKVWNLANCK-------LKTNHIGHTGYLNTVTVSP-D 203 + ++PN N ++S D + +W++ K GHT + V Sbjct: 187 YGLSWNPN-LNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLH 245 Query: 204 GSLCASGGKDGQAMLWDL---NEGKHLYTLDGGD-IINALCFSPNRYWLCA--ATGPSIK 257 SL S D + M+WD N K +T+D +N L F+P ++ A + ++ Sbjct: 246 ESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVA 305 Query: 258 IWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQT-LFAGYTDNLVRVWQVTI 314 +WDL ++ S ++ + + WS +T L + TD + VW ++ Sbjct: 306 LWDLRN--------LKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSK 355 Score = 52.0 bits (123), Expect = 3e-07, Method: Composition-based stats. Identities = 25/146 (17%), Positives = 46/146 (31%), Gaps = 17/146 (11%) Query: 185 KTNHIGHTGYLNTVTVSP-DGSLCASGGKDGQAMLWDLN--------EGKHLYTLD---G 232 I H G +N P + + A+ +++D G+ L Sbjct: 123 IEIKINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGH 182 Query: 233 GDIINALCFSPN--RYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLA 290 L ++PN Y L A+ +I +WD+ E + +A Sbjct: 183 QKEGYGLSWNPNLNGYLLSASDDHTICLWDI--NATPKEHRVIDAKNIFTGHTAVVEDVA 240 Query: 291 WSADGQTLF-AGYTDNLVRVWQVTIG 315 W ++LF + D + +W Sbjct: 241 WHLLHESLFGSVADDQKLMIWDTRNN 266 Score = 38.9 bits (89), Expect = 0.003, Method: Composition-based stats. Identities = 11/44 (25%), Positives = 21/44 (47%) Query: 13 GHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQ 56 GH ++ + P P +I S S D + +W++ + N P+ Sbjct: 378 GHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENVYNDEEPE 421 >2YNP-A nrPDB Length = 604 Score = 166 bits (419), Expect = 2e-41, Method: Composition-based stats. Identities = 62/308 (20%), Positives = 113/308 (36%), Gaps = 23/308 (7%) Query: 5 MTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSH 64 + ++ T + V I P P +L+ + +W + R+++ Sbjct: 3 LDIKKTFSNRSDRVKGIDFHPTEP-WVLTTLYSGRVELWNYETQ-----VEVRSIQVTET 56 Query: 65 FVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGS 124 V + + + GS D +R+++ TG F H + S+A ++SGS Sbjct: 57 PVRAGKFIARKNWIIVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGS 116 Query: 125 RDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKL 184 D T+KLWN E H +V CV F+P + S D+ VKVW+L Sbjct: 117 DDLTVKLWNWENNWALEQTFEGHEHFVMCVAFNPKDPS-TFASGCLDRTVKVWSLGQSTP 175 Query: 185 KTNH-IGHTGYLNTVTV--SPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGG-DIINALC 240 G +N V PD + D +WD + TL+G ++ Sbjct: 176 NFTLTTGQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAV 235 Query: 241 FSPNRYWLCAAT-GPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQ--T 297 F P + + + ++KIW+ + L + + +A G+ Sbjct: 236 FHPTLPIIISGSEDGTLKIWNSSTYKVEKTLNVGLERS---------WCIATHPTGRKNY 286 Query: 298 LFAGYTDN 305 + +G+ + Sbjct: 287 IASGFDNG 294 Score = 162 bits (409), Expect = 2e-40, Method: Composition-based stats. Identities = 72/357 (20%), Positives = 121/357 (33%), Gaps = 67/357 (18%) Query: 4 QMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHS 63 L T +GH +V +A P+ P S D+T+ +W L + N+ + RG + Sbjct: 129 NWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQERGVN 188 Query: 64 HFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSG 123 + D D + ++ S D T+++WD T + GH +V F I+SG Sbjct: 189 YV--DYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAVFHPTLPIIISG 246 Query: 124 SRDKTIKLWNTLG-VCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANC 182 S D T+K+WN+ + T+ W C+ P I S G+D V +L N Sbjct: 247 SEDGTLKIWNSSTYKVEKTLNVGLERSW--CIATHPTGRKNYIAS-GFDNGFTVLSLGND 303 Query: 183 KLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDII------ 236 + T+++ P G L SGGK+ A + G + + Sbjct: 304 EP------------TLSLDPVGKLVWSGGKNAAA------SDIFTAVIRGNEEVEQDEPL 345 Query: 237 --------------NALCFSPNRYWLCAATGP------------------SIKIWDLEGK 264 +L SPN ++ +W + Sbjct: 346 SLQTKELGSVDVFPQSLAHSPNGRFVTVVGDGEYVIYTALAWRNKAFGKCQDFVWGPDSN 405 Query: 265 IIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGY-----TDNLVRVWQVTIGT 316 + I + S+ + LF+G +D V + GT Sbjct: 406 SYALIDETGQIKYYKNFKEVTSWSVPMHSAIDRLFSGALLGVKSDGFVYFFDWDNGT 462 Score = 156 bits (395), Expect = 9e-39, Method: Composition-based stats. Identities = 50/249 (20%), Positives = 91/249 (36%), Gaps = 10/249 (4%) Query: 29 DMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLR 88 + I+ S D I ++ E H ++ + + + LSGS D T++ Sbjct: 68 NWIIVGSDDFRIRVFNYNTGEKVVD-----FEAHPDYIRSIAVHPTKPYVLSGSDDLTVK 122 Query: 89 LWDLTTG-TTTRRFVGHTKDVLSVAFSS-DNRQIVSGSRDKTIKLWNTLGVCKYTVQDES 146 LW+ + F GH V+ VAF+ D SG D+T+K+W+ Sbjct: 123 LWNWENNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTG 182 Query: 147 HSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSL 206 V+ V + P P +++ D +K+W+ GH ++ P + Sbjct: 183 QERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAVFHPTLPI 242 Query: 207 CASGGKDGQAMLWDLNEGKHLYTLDGGDIIN-ALCFSPNR--YWLCAATGPSIKIWDLEG 263 SG +DG +W+ + K TL+ G + + P ++ + + L Sbjct: 243 IISGSEDGTLKIWNSSTYKVEKTLNVGLERSWCIATHPTGRKNYIASGFDNGFTVLSLGN 302 Query: 264 KIIVDELKQ 272 L Sbjct: 303 DEPTLSLDP 311 Score = 65.9 bits (159), Expect = 2e-11, Method: Composition-based stats. Identities = 18/129 (13%), Positives = 43/129 (33%), Gaps = 11/129 (8%) Query: 185 KTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGD-IINALCFSP 243 K + + + P + G+ LW+ + ++ + + A F Sbjct: 6 KKTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVELWNYETQVEVRSIQVTETPVRAGKFIA 65 Query: 244 NRYWLCAATGP-SIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGY 302 + W+ + I++++ V + + A P S+A + +G Sbjct: 66 RKNWIIVGSDDFRIRVFNYNTGEKVVDFE---------AHPDYIRSIAVHPTKPYVLSGS 116 Query: 303 TDNLVRVWQ 311 D V++W Sbjct: 117 DDLTVKLWN 125 Score = 35.1 bits (79), Expect = 0.041, Method: Composition-based stats. Identities = 13/85 (15%), Positives = 30/85 (35%), Gaps = 10/85 (11%) Query: 234 DIINALCFSPNRYWLCAA-TGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWS 292 D + + F P W+ +++W+ E ++ V ++ + + Sbjct: 14 DRVKGIDFHPTEPWVLTTLYSGRVELWNYETQVEVRSIQVTETP---------VRAGKFI 64 Query: 293 ADGQTLFAGYTDNLVRVWQVTIGTR 317 A + G D +RV+ G + Sbjct: 65 ARKNWIIVGSDDFRIRVFNYNTGEK 89 >5Y1U-A nrPDB Length = 456 Score = 165 bits (418), Expect = 2e-41, Method: Composition-based stats. Identities = 71/303 (23%), Positives = 130/303 (42%), Gaps = 36/303 (11%) Query: 14 HNGWVTQIATTPQFPDMILSASRDKTIIMWKLTR-----DETNYGIPQRALRGHSHFVSD 68 H G V + PQ P +I + + ++++ T+ D + P LRGH Sbjct: 154 HEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYG 213 Query: 69 VVISSD-GQFALSGSWDGTLRLWDLTTGTTTRR-------FVGHTKDVLSVAFSSDNRQI 120 + + + LS S D T+ LWD++ + F GHT V V++ + + Sbjct: 214 LSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESL 273 Query: 121 V-SGSRDKTIKLWNTLG--VCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVW 177 S + D+ + +W+T K + ++H+ V+C+ F+P S I+ + DK V +W Sbjct: 274 FGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNP-YSEFILATGSADKTVALW 332 Query: 178 NLANCKLKTN-HIGHTGYLNTVTVSP-DGSLCASGGKDGQAMLWDLNE-GKHLYTLDGGD 234 +L N KLK + H + V SP + ++ AS G D + +WDL++ G+ D D Sbjct: 333 DLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAED 392 Query: 235 I--------------INALCFSPNRYWLCA--ATGPSIKIWDLEGKIIVDELKQEVISTS 278 I+ ++PN W+ + +++W + I DE + + Sbjct: 393 GPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPE 452 Query: 279 SKA 281 + Sbjct: 453 GQG 455 Score = 164 bits (414), Expect = 6e-41, Method: Composition-based stats. Identities = 59/236 (25%), Positives = 101/236 (42%), Gaps = 23/236 (9%) Query: 11 LKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLT--RDETNYGIPQRALRGHSHFVSD 68 L+GH ++ P +LSAS D TI +W ++ E + GH+ V D Sbjct: 204 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVED 263 Query: 69 VVIS-SDGQFALSGSWDGTLRLWDLTTGTT---TRRFVGHTKDVLSVAFSSDNRQI-VSG 123 V S + D L +WD + T + HT +V ++F+ + I +G Sbjct: 264 VSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATG 323 Query: 124 SRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLA--- 180 S DKT+ LW+ + ESH + + V++SP++ I+ S G D+ + VW+L+ Sbjct: 324 SADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNET-ILASSGTDRRLNVWDLSKIG 382 Query: 181 -----------NCKLKTNHIGHTGYLNTVTVSPDGSLCA-SGGKDGQAMLWDLNEG 224 +L H GHT ++ + +P+ S +D +W + E Sbjct: 383 EEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAEN 438 Score = 110 bits (275), Expect = 7e-25, Method: Composition-based stats. Identities = 37/189 (19%), Positives = 74/189 (39%), Gaps = 19/189 (10%) Query: 5 MTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSH 64 + + GH V ++ + S + D+ +++W + N P ++ H+ Sbjct: 248 VDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSN--NTSKPSHSVDAHTA 305 Query: 65 FVSDVVISSDGQF-ALSGSWDGTLRLWDLTTGT-TTRRFVGHTKDVLSVAFSSDNR-QIV 121 V+ + + +F +GS D T+ LWDL F H ++ V +S N + Sbjct: 306 EVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILA 365 Query: 122 SGSRDKTIKLWNTL-------------GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSC 168 S D+ + +W+ G + H+ +S ++PN +I S Sbjct: 366 SSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEP-WVICSV 424 Query: 169 GWDKLVKVW 177 D +++VW Sbjct: 425 SEDNIMQVW 433 Score = 105 bits (262), Expect = 3e-23, Method: Composition-based stats. Identities = 53/268 (19%), Positives = 103/268 (38%), Gaps = 43/268 (16%) Query: 72 SSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIV---SGSRDKT 128 S G+F GS G + + + H +V + N I+ + S D Sbjct: 131 SEKGEFGGFGSVSGKIEI---------EIKINHEGEVNRARYMPQNPCIIATKTPSSDVL 181 Query: 129 IKLW-------NTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLAN 181 + + + G C ++ H + + ++PN S ++ S D + +W+++ Sbjct: 182 VFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLL-SASDDHTICLWDISA 240 Query: 182 CK-------LKTNHIGHTGYLNTVTVSP-DGSLCASGGKDGQAMLWDLNEG---KHLYTL 230 KT GHT + V+ SL S D + M+WD K +++ Sbjct: 241 VPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSV 300 Query: 231 DGGD-IINALCFSPNRYWLCA--ATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCT 287 D +N L F+P ++ A + ++ +WDL ++ S ++ + Sbjct: 301 DAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRN--------LKLKLHSFESHKDEIF 352 Query: 288 SLAWSADGQT-LFAGYTDNLVRVWQVTI 314 + WS +T L + TD + VW ++ Sbjct: 353 QVQWSPHNETILASSGTDRRLNVWDLSK 380 Score = 84.0 bits (206), Expect = 9e-17, Method: Composition-based stats. Identities = 27/144 (18%), Positives = 51/144 (35%), Gaps = 20/144 (13%) Query: 6 TLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHF 65 ++ H V ++ P ++ + S DKT+ +W L N + + H Sbjct: 295 KPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLR----NLKLKLHSFESHKDE 350 Query: 66 VSDVVISSDGQ-FALSGSWDGTLRLWDLTTGTTTRRFV--------------GHTKDVLS 110 + V S + S D L +WDL+ + GHT + Sbjct: 351 IFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISD 410 Query: 111 VAFSSDNRQ-IVSGSRDKTIKLWN 133 +++ + I S S D +++W Sbjct: 411 FSWNPNEPWVICSVSEDNIMQVWQ 434 Score = 67.8 bits (164), Expect = 6e-12, Method: Composition-based stats. Identities = 45/252 (17%), Positives = 78/252 (30%), Gaps = 33/252 (13%) Query: 88 RLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDES- 146 + L GT T H + SV +D+ Q + D + G ++ E Sbjct: 93 SIHRLVLGTHTSDEQNHLV-IASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIK 151 Query: 147 --HSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWN----------LANCKLKTNHIGHTGY 194 H V+ R+ P + II + V V++ C GH Sbjct: 152 INHEGEVNRARYMPQNP-CIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKE 210 Query: 195 LNTVTVSPD-GSLCASGGKDGQAMLWDLN----EGK----HLYTLDGGDIINALCFSP-- 243 ++ +P+ S D LWD++ EGK ++ + + Sbjct: 211 GYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLH 270 Query: 244 NRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQ-TLFAGY 302 + A + IWD S S A + L+++ + L G Sbjct: 271 ESLFGSVADDQKLMIWDTRSNNTSKP------SHSVDAHTAEVNCLSFNPYSEFILATGS 324 Query: 303 TDNLVRVWQVTI 314 D V +W + Sbjct: 325 ADKTVALWDLRN 336 Score = 37.4 bits (85), Expect = 0.010, Method: Composition-based stats. Identities = 11/44 (25%), Positives = 21/44 (47%) Query: 13 GHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQ 56 GH ++ + P P +I S S D + +W++ + N P+ Sbjct: 403 GHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPE 446 >6EOJ-D nrPDB Length = 470 Score = 165 bits (417), Expect = 2e-41, Method: Composition-based stats. Identities = 61/288 (21%), Positives = 107/288 (37%), Gaps = 43/288 (14%) Query: 63 SHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVS 122 H + + + +G+ + ++ G LW+ ++ T H V ++ +S D+ ++S Sbjct: 93 KHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMIS 152 Query: 123 GSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANC 182 G D IK+W + D +H+E + + FS N S V+C D ++K+WN +N Sbjct: 153 GDADGMIKIWQPNFSMVKEI-DAAHTESIRDMAFSSNDSK--FVTCSDDNILKIWNFSNG 209 Query: 183 KLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYT-LDGGDIINALCF 241 K + GH + + P+ L AS KD LWD G + + L + F Sbjct: 210 KQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRF 269 Query: 242 SPNR--YWLCAATGPSIKIWDLE-----------------------------GKIIVDEL 270 P + + + S +++D+ L Sbjct: 270 QPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSL 329 Query: 271 KQ--------EVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVW 310 K E I T A TSL+++ G D +R W Sbjct: 330 KHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFW 377 Score = 150 bits (378), Expect = 8e-37, Method: Composition-based stats. Identities = 58/263 (22%), Positives = 108/263 (41%), Gaps = 16/263 (6%) Query: 4 QMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHS 63 T ++ H+ VT + + D ++S D I +W + N+ + + H+ Sbjct: 124 SFTFETLMQAHDSAVTTMKYSHD-SDWMISGDADGMIKIW-----QPNFSMVKEIDAAHT 177 Query: 64 HFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSG 123 + D+ SS+ ++ S D L++W+ + G R GH DV S + + I S Sbjct: 178 ESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASA 237 Query: 124 SRDKTIKLWNTL-GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANC 182 S+D +KLW+ G C ++ H+ V RF P ++++ DK +V+++ Sbjct: 238 SKDNLVKLWDPRSGNCISSILKFKHT--VLKTRFQPT-KGNLLMAISKDKSCRVFDIRYS 294 Query: 183 KLKTNHIGHTGYLNTVTVSP-DGSLCASGGKDGQAMLWD----LNEGKHLYTLDGGDIIN 237 + + T+ P + S+ DG +D LNE I Sbjct: 295 MKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCIT 354 Query: 238 ALCFSPNRYWLC-AATGPSIKIW 259 +L ++P + AA +I+ W Sbjct: 355 SLSYNPVGHIFATAAKDRTIRFW 377 Score = 94.4 bits (233), Expect = 6e-20, Method: Composition-based stats. Identities = 35/194 (18%), Positives = 65/194 (33%), Gaps = 17/194 (8%) Query: 124 SRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCK 183 RD+ I L + H + ++++P ++ + + +WN ++ Sbjct: 73 GRDRVINL--PSKFTHLSSNKVKH--VIPAIQWTPEGRRLVVAT--YSGEFSLWNASSFT 126 Query: 184 LKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLN-EGKHLYTLDGGDIINALCFS 242 +T H + T+ S D SG DG +W N + I + FS Sbjct: 127 FETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFS 186 Query: 243 PN-RYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAG 301 N ++ + +KIW+ L S W + + + Sbjct: 187 SNDSKFVTCSDDNILKIWNFSNGKQERVL---------SGHHWDVKSCDWHPEMGLIASA 237 Query: 302 YTDNLVRVWQVTIG 315 DNLV++W G Sbjct: 238 SKDNLVKLWDPRSG 251 Score = 67.4 bits (163), Expect = 8e-12, Method: Composition-based stats. Identities = 21/125 (16%), Positives = 47/125 (37%), Gaps = 11/125 (8%) Query: 195 LNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDI-INALCFSPNRYWLCAAT- 252 + + +P+G G+ LW+ + + D + + +S + W+ + Sbjct: 96 IPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDA 155 Query: 253 GPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQV 312 IKIW +V E+ A +A+S++ DN++++W Sbjct: 156 DGMIKIWQ-PNFSMVKEID--------AAHTESIRDMAFSSNDSKFVTCSDDNILKIWNF 206 Query: 313 TIGTR 317 + G + Sbjct: 207 SNGKQ 211 Score = 29.3 bits (64), Expect = 2.5, Method: Composition-based stats. Identities = 9/54 (16%), Positives = 18/54 (33%) Query: 261 LEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTI 314 G+ V L + SS ++ W+ +G+ L +W + Sbjct: 71 YRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASS 124 >5A31-R nrPDB Length = 386 Score = 163 bits (412), Expect = 9e-41, Method: Composition-based stats. Identities = 55/252 (21%), Positives = 102/252 (40%), Gaps = 19/252 (7%) Query: 67 SDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRD 126 + + G G +G + ++D+ R GH V ++++ N + SGSRD Sbjct: 135 TSLSWIGAGSHLAVGQANGLVEIYDVMKRKCIRTLSGHIDRVACLSWN--NHVLTSGSRD 192 Query: 127 KTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKT 186 I + + ESH++ V +++ N ++ + S G D +V V+ + Sbjct: 193 HRILHRDVRMPDPFFETIESHTQEVCGLKW--NVADNKLASGGNDNVVHVYEGTSKSPIL 250 Query: 187 NHIGHTGYLNTVTVSPDGS-LCASGG--KDGQAMLWDLNEGKHLYTLDGGDIINALCFSP 243 H + + SP + A+GG D + +W++N + +D G I + +S Sbjct: 251 TFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDIDSGSQICNMVWSK 310 Query: 244 NRYWLCAATGPS---IKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFA 300 N L + G S + +WD + LK + L S DG T+ + Sbjct: 311 NTNELVTSHGYSKYNLTLWDCNSMDPIAILK---------GHSFRVLHLTLSNDGTTVVS 361 Query: 301 GYTDNLVRVWQV 312 G D +R W++ Sbjct: 362 GAGDETLRYWKL 373 Score = 117 bits (294), Expect = 6e-27, Method: Composition-based stats. Identities = 50/217 (23%), Positives = 91/217 (41%), Gaps = 14/217 (6%) Query: 9 GTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSD 68 TL GH V ++ ++ S SRD I L RD + H+ V Sbjct: 167 RTLSGHIDRVACLSWN---NHVLTSGSRDHRI----LHRDVRMPDPFFETIESHTQEVCG 219 Query: 69 VVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVS---GSR 125 + + SG D + +++ T+ + F H V ++A+S R +++ G+ Sbjct: 220 LKWNVADNKLASGGNDNVVHVYEGTSKSPILTFDEHKAAVKAMAWSPHKRGVLATGGGTA 279 Query: 126 DKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDK-LVKVWNLANCKL 184 D+ +K+WN K + D + + +S N +N ++ S G+ K + +W+ + Sbjct: 280 DRRLKIWNVNTSIKMSDIDSGSQ--ICNMVWSKN-TNELVTSHGYSKYNLTLWDCNSMDP 336 Query: 185 KTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDL 221 GH+ + +T+S DG+ SG D W L Sbjct: 337 IAILKGHSFRVLHLTLSNDGTTVVSGAGDETLRYWKL 373 Score = 94.0 bits (232), Expect = 7e-20, Method: Composition-based stats. Identities = 39/253 (15%), Positives = 90/253 (35%), Gaps = 16/253 (6%) Query: 15 NGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSD 74 T ++ + + + ++ + + + R L GH V+ + + Sbjct: 131 ENEYTSLSWIGAGSH-LAVGQANGLVEIYDVMKRK-----CIRTLSGHIDRVACLSW--N 182 Query: 75 GQFALSGSWDGTLRLWDLT-TGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWN 133 SGS D + D+ HT++V + ++ + ++ SG D + ++ Sbjct: 183 NHVLTSGSRDHRILHRDVRMPDPFFETIESHTQEVCGLKWNVADNKLASGGNDNVVHVYE 242 Query: 134 TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCG-WDKLVKVWNLANCKLKTNHIGHT 192 + + H V + +SP+ + G D+ +K+WN+ ++ Sbjct: 243 GTSKS-PILTFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDIDS-G 300 Query: 193 GYLNTVTVSPDGSLCAS--GGKDGQAMLWDLNEGKHLYTLDGGDI-INALCFSPNRYWLC 249 + + S + + + G LWD N + L G + L S + + Sbjct: 301 SQICNMVWSKNTNELVTSHGYSKYNLTLWDCNSMDPIAILKGHSFRVLHLTLSNDGTTVV 360 Query: 250 AATGP-SIKIWDL 261 + G +++ W L Sbjct: 361 SGAGDETLRYWKL 373 Score = 67.8 bits (164), Expect = 6e-12, Method: Composition-based stats. Identities = 27/142 (19%), Positives = 52/142 (36%), Gaps = 10/142 (7%) Query: 10 TLKGHNGWVTQIATTPQFPDMILSAS--RDKTIIMWKLTRDETNYGIPQRALRGHSHFVS 67 T H V +A +P ++ + D+ + +W + I + Sbjct: 251 TFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDIDS------GSQIC 304 Query: 68 DVVISSDGQFALSGS--WDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSR 125 ++V S + ++ L LWD + GH+ VL + S+D +VSG+ Sbjct: 305 NMVWSKNTNELVTSHGYSKYNLTLWDCNSMDPIAILKGHSFRVLHLTLSNDGTTVVSGAG 364 Query: 126 DKTIKLWNTLGVCKYTVQDESH 147 D+T++ W V + Sbjct: 365 DETLRYWKLFDVSVLNLFTRIR 386 Score = 47.8 bits (112), Expect = 6e-06, Method: Composition-based stats. Identities = 23/121 (19%), Positives = 47/121 (38%), Gaps = 10/121 (8%) Query: 192 TGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGG-DIINALCFSPNRYWLCA 250 +++ GS A G +G ++D+ + K + TL G D + L ++ N Sbjct: 131 ENEYTSLSWIGAGSHLAVGQANGLVEIYDVMKRKCIRTLSGHIDRVACLSWN-NHVLTSG 189 Query: 251 ATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVW 310 + I D+ + + ++ + L W+ L +G DN+V V+ Sbjct: 190 SRDHRILHRDVR--------MPDPFFETIESHTQEVCGLKWNVADNKLASGGNDNVVHVY 241 Query: 311 Q 311 + Sbjct: 242 E 242 >5WYK-BB nrPDB Length = 943 Score = 162 bits (411), Expect = 1e-40, Method: Composition-based stats. Identities = 66/322 (20%), Positives = 128/322 (39%), Gaps = 38/322 (11%) Query: 11 LKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVV 70 L+G V I + ++ +AS ++ +W + + R + Sbjct: 387 LQGQRTDVRSIDIS-DDNKLLATASN-GSLKIWNIKTHK-----CIRTFE--CGYALTCK 437 Query: 71 ISSDGQFALSGSWDGTLRLWDLTTGTTTRRFV-GHTKDVLSVAFSSDNRQIVSGSRDKTI 129 G + G+ +G L+L+DL + + H + S+ +SD +++V+GS DKT+ Sbjct: 438 FLPGGLLVILGTRNGELQLFDLASSSLLDTIEDAHDAAIWSLDLTSDGKRLVTGSADKTV 497 Query: 130 KLWNTL--------GVCKYTVQDESH-------SEWVSCVRFSPNSSNPIIVSCGWDKLV 174 K W+ K+ + H ++ + CVR SP+ + D V Sbjct: 498 KFWDFKVENSLVPGTKNKFLPVLKLHHDTTLELTDDILCVRVSPDDR--YLAISLLDNTV 555 Query: 175 KVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYT-LDGG 233 KV+ L + K + GH + ++ +S D + + D +W L+ G + Sbjct: 556 KVFFLDSMKFYLSLYGHKLPVLSIDISFDSKMIITSSADKNIKIWGLDFGDCHKSLFAHQ 615 Query: 234 DIINALCFSPNRY-WLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWS 292 D I + F P + + + +K WD E + +L A + +LA + Sbjct: 616 DSIMNVKFLPQSHNFFSCSKDAVVKYWDGEKFECIQKL---------YAHQSEVWALAVA 666 Query: 293 ADGQTLFAGYTDNLVRVWQVTI 314 DG + + D+ +R+W+ T Sbjct: 667 TDGGFVVSSSHDHSIRIWEETE 688 Score = 159 bits (401), Expect = 2e-39, Method: Composition-based stats. Identities = 53/225 (23%), Positives = 92/225 (40%), Gaps = 17/225 (7%) Query: 13 GHNGWVTQIATTPQFPDMILSASRDKTIIMWK------LTRDETNYGIPQRALRGHS--- 63 H+ + + T +++ S DKT+ W L N +P L + Sbjct: 471 AHDAAIWSLDLT-SDGKRLVTGSADKTVKFWDFKVENSLVPGTKNKFLPVLKLHHDTTLE 529 Query: 64 --HFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIV 121 + V +S D ++ D T++++ L + GH VLS+ S D++ I+ Sbjct: 530 LTDDILCVRVSPDDRYLAISLLDNTVKVFFLDSMKFYLSLYGHKLPVLSIDISFDSKMII 589 Query: 122 SGSRDKTIKLWNT-LGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLA 180 + S DK IK+W G C ++ +H + + V+F P S N SC D +VK W+ Sbjct: 590 TSSADKNIKIWGLDFGDCHKSLF--AHQDSIMNVKFLPQSHN--FFSCSKDAVVKYWDGE 645 Query: 181 NCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGK 225 + H + + V+ DG S D +W+ E + Sbjct: 646 KFECIQKLYAHQSEVWALAVATDGGFVVSSSHDHSIRIWEETEDQ 690 Score = 114 bits (284), Expect = 8e-26, Method: Composition-based stats. Identities = 46/201 (22%), Positives = 80/201 (39%), Gaps = 15/201 (7%) Query: 28 PDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSD-------VVISSDGQFALS 80 +I SA D + +W + + + G S + D Sbjct: 39 GQLITSALED--VNIWDIKTGDLVSKLSDGLPPGASDARGAKPAECTYLEAHKDTDLLAV 96 Query: 81 GSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKY 140 G DG +++WDL + T F GH + + F +++SGS+D I +W+ +G Sbjct: 97 GYADGVIKVWDLMSKTVLLNFNGHKAAITLLQFDGTGTRLISGSKDSNIIVWDLVGEV-G 155 Query: 141 TVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTV 200 + SH + ++ ++S D ++K+W+L + HI HTG + V Sbjct: 156 LYKLRSHKDSITGFWC---QGEDWLISTSKDGMIKLWDLKTHQCIETHIAHTGECWGLAV 212 Query: 201 SPDGSLCASGGKDGQAMLWDL 221 D L + G D Q +W L Sbjct: 213 KDD--LLITTGTDSQVKIWKL 231 Score = 104 bits (258), Expect = 8e-23, Method: Composition-based stats. Identities = 33/131 (25%), Positives = 59/131 (45%), Gaps = 6/131 (4%) Query: 2 TEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRG 61 + M +L GH V I + MI+++S DK I +W L ++G ++L Sbjct: 560 LDSMKFYLSLYGHKLPVLSIDIS-FDSKMIITSSADKNIKIWGL-----DFGDCHKSLFA 613 Query: 62 HSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIV 121 H + +V S S D ++ WD ++ H +V ++A ++D +V Sbjct: 614 HQDSIMNVKFLPQSHNFFSCSKDAVVKYWDGEKFECIQKLYAHQSEVWALAVATDGGFVV 673 Query: 122 SGSRDKTIKLW 132 S S D +I++W Sbjct: 674 SSSHDHSIRIW 684 Score = 100 bits (250), Expect = 6e-22, Method: Composition-based stats. Identities = 49/347 (14%), Positives = 104/347 (29%), Gaps = 70/347 (20%) Query: 25 PQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWD 84 + D++ D I +W L GH ++ + G +SGS D Sbjct: 88 HKDTDLLAVGYADGVIKVWDLMSKTVLLN-----FNGHKAAITLLQFDGTGTRLISGSKD 142 Query: 85 GTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNT-LGVCKYTVQ 143 + +WDL + H + + ++S S+D IKLW+ C T Sbjct: 143 SNIIVWDLVGEVGLYKLRSHKDSITGF-WCQGEDWLISTSKDGMIKLWDLKTHQCIETHI 201 Query: 144 DESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVW--NLANCKL----------KTNHIGH 191 + W V+ + ++++ G D VK+W ++ N K+ + Sbjct: 202 AHTGECWGLAVK------DDLLITTGTDSQVKIWKLDIENDKMGGKLTEMGIFEKQSKQR 255 Query: 192 TGYLNTVTVSPD-GSLCASGGKDGQAMLWDLNEGKHL----------------------- 227 + +T S D S D + + + + + Sbjct: 256 GLKIEFITNSSDKTSFFYIQNADKTIETFRIRKEEEIARGLKKREKRLKEKGLTEEEIAK 315 Query: 228 --------------YTLDGGDIINALCF----SPNRYWLCAATGPSIKIWD--LEGKIIV 267 T+ I + + S + + +I+ + E + Sbjct: 316 SIKESYSSFILHPFQTIRSLYKIKSASWTTVSSSKLELVLTTSSNTIEYYSIPYEKRDPT 375 Query: 268 DELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTI 314 + + + + S+ S D + L +++W + Sbjct: 376 SPAPLKTHTIELQGQRTDVRSIDISDDNKLLATASN-GSLKIWNIKT 421 Score = 100 bits (250), Expect = 7e-22, Method: Composition-based stats. Identities = 43/236 (18%), Positives = 85/236 (36%), Gaps = 36/236 (15%) Query: 101 FVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNT-LGVCKYTVQDESHSEWVSCVRFSPN 159 G DV S+ S DN+ + + S ++K+WN C T + + +F P Sbjct: 387 LQGQRTDVRSIDISDDNKLLATASN-GSLKIWNIKTHKCIRTFECG----YALTCKFLP- 440 Query: 160 SSNPIIVSCGWDKLVKVWNLANCKLKTN-HIGHTGYLNTVTVSPDGSLCASGGKDGQAML 218 +++ + +++++LA+ L H + ++ ++ DG +G D Sbjct: 441 -GGLLVILGTRNGELQLFDLASSSLLDTIEDAHDAAIWSLDLTSDGKRLVTGSADKTVKF 499 Query: 219 WDLNEGKHLY-----------------TLDGGDIINALCFSPN-RYWLCAATGPSIKIWD 260 WD L TL+ D I + SP+ RY + ++K++ Sbjct: 500 WDFKVENSLVPGTKNKFLPVLKLHHDTTLELTDDILCVRVSPDDRYLAISLLDNTVKVFF 559 Query: 261 LEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGT 316 L+ L S+ S D + + D +++W + G Sbjct: 560 LDSMKFYLSL---------YGHKLPVLSIDISFDSKMIITSSADKNIKIWGLDFGD 606 Score = 99.4 bits (246), Expect = 2e-21, Method: Composition-based stats. Identities = 42/208 (20%), Positives = 76/208 (36%), Gaps = 23/208 (11%) Query: 117 NRQIVSGSRDKTIKLWNTLGVCKYTVQDESH---------SEWVSCVRFSPNSSNPIIVS 167 + I S D + +W+ + + ++ C + ++ Sbjct: 39 GQLITSALED--VNIWDIKTGDLVSKLSDGLPPGASDARGAKPAECTYLEAHKDTDLLAV 96 Query: 168 CGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHL 227 D ++KVW+L + + N GH + + G+ SG KD ++WDL L Sbjct: 97 GYADGVIKVWDLMSKTVLLNFNGHKAAITLLQFDGTGTRLISGSKDSNIIVWDLVGEVGL 156 Query: 228 YTLDGGDIINALCFSPNRYWLCAAT-GPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQC 286 Y L + WL + + IK+WDL+ ++ A +C Sbjct: 157 YKLRSHKDSITGFWCQGEDWLISTSKDGMIKLWDLKTHQCIET---------HIAHTGEC 207 Query: 287 TSLAWSADGQTLFAGYTDNLVRVWQVTI 314 LA D L TD+ V++W++ I Sbjct: 208 WGLAVKDD--LLITTGTDSQVKIWKLDI 233 >5OQL-d nrPDB Length = 446 Score = 161 bits (407), Expect = 4e-40, Method: Composition-based stats. Identities = 54/261 (20%), Positives = 98/261 (37%), Gaps = 15/261 (5%) Query: 61 GHSHFVSDVVISSDG-QFALSGSWDGTLRLWDLTTGTTTR-RFVGHTKDVLSVAFSSDNR 118 GH V + + SGS DG +++WDLTT R H V + F++D + Sbjct: 64 GHVQGVYSMCKDKNSLNCIASGSGDGVVKVWDLTTRDEETWRVAAHNNIVKGLTFTND-K 122 Query: 119 QIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWN 178 +++S + D IKLW+ T + E S + S + +++W+ Sbjct: 123 KLLSCATDG-IKLWDPYASPSNTTPIATWQEGGPYTSLSFHRSANTFAASSGQGCIRIWD 181 Query: 179 LANCKLKTNHIGHTGYLNTVTV----SPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGD 234 L + I +++T+T + S+ S D +L+DL + Sbjct: 182 LEH-STAGQAIQWPSFVDTITDVCFNQVETSVIGSVATDRSIILFDLRTNMPVIKTVLHF 240 Query: 235 IINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSAD 294 N + F+P A I+ + + L + K + +S Sbjct: 241 ACNRIVFNPMEAMNLAVASEDHNIYIFDARNFDKALNIQ------KGHVAAVMDVEFSPT 294 Query: 295 GQTLFAGYTDNLVRVWQVTIG 315 G+ L +G D +R+W+ G Sbjct: 295 GEELVSGSYDRTIRLWRRDAG 315 Score = 141 bits (356), Expect = 3e-34, Method: Composition-based stats. Identities = 53/314 (16%), Positives = 110/314 (35%), Gaps = 24/314 (7%) Query: 12 KGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVI 71 GH V + + I S S D + +W LT + + H++ V + Sbjct: 63 NGHVQGVYSMCKDKNSLNCIASGSGDGVVKVWDLTTRDEE----TWRVAAHNNIVKGLTF 118 Query: 72 SSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHT---KDVLSVAFSSDNRQIVSGSRDKT 128 ++D + LS + DG ++LWD + + S++F + S Sbjct: 119 TNDKK-LLSCATDG-IKLWDPYASPSNTTPIATWQEGGPYTSLSFHRSANTFAASSGQGC 176 Query: 129 IKLWNTLG-VCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTN 187 I++W+ +Q S + ++ V F+ +I S D+ + +++L Sbjct: 177 IRIWDLEHSTAGQAIQWPSFVDTITDVCFN-QVETSVIGSVATDRSIILFDLRTNMPVIK 235 Query: 188 HIGHTGYLNTVTVSPDGSL-CASGGKDGQAMLWDLNEGKHLYTLD--GGDIINALCFSPN 244 + H N + +P ++ A +D ++D + + + FSP Sbjct: 236 TVLH-FACNRIVFNPMEAMNLAVASEDHNIYIFDARNFDKALNIQKGHVAAVMDVEFSPT 294 Query: 245 RYWLCAAT-GPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYT 303 L + + +I++W + + W+ D + + G Sbjct: 295 GEELVSGSYDRTIRLWRRDAG--------HSRDVYHTKRMQRVFRTMWTMDSKYILTGSD 346 Query: 304 DNLVRVWQVTIGTR 317 D VR+W+ R Sbjct: 347 DGNVRLWRANASER 360 Score = 32.4 bits (72), Expect = 0.27, Method: Composition-based stats. Identities = 11/67 (16%), Positives = 19/67 (28%), Gaps = 8/67 (11%) Query: 3 EQMTLRGTLKGHNGWVTQIATT--------PQFPDMILSASRDKTIIMWKLTRDETNYGI 54 + L GH+ V IL+ S D + +W+ E + Sbjct: 305 RTIRLWRRDAGHSRDVYHTKRMQRVFRTMWTMDSKYILTGSDDGNVRLWRANASERSGVK 364 Query: 55 PQRALRG 61 R + Sbjct: 365 ATRQRQA 371 >3JB9-g nrPDB Length = 558 Score = 161 bits (407), Expect = 4e-40, Method: Composition-based stats. Identities = 66/304 (21%), Positives = 106/304 (34%), Gaps = 59/304 (19%) Query: 10 TLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDV 69 T KGH ++ + P ++LS S D I +W++ D + R +GH+ + D+ Sbjct: 261 TWKGHTKGISCLRFFPISGHLLLSGSMDNQIKIWEVYHDRS----LLRTFQGHARPIRDL 316 Query: 70 VISSDGQFALSGSWDGTLRLWDLTTGTTT------------------------------- 98 S DG+ LS S+D T++LWD G Sbjct: 317 SFSQDGRSFLSTSFDKTIKLWDTELGKCLNCFNSDRLTNCVKFQVDPDKPNEFLAGTADK 376 Query: 99 -------------RRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDE 145 + + H + S+ F + ++ V+ S D +++ W + Sbjct: 377 RILQFDIRSPDIVQAYDHHLGGINSITFLENGKRFVTTSDDSSMRFWEYGTPVPIKFVAD 436 Query: 146 SHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNL-----ANCKLKTNHIGHTGYLNTVTV 200 + V PN + I D + V++ N K +GY V Sbjct: 437 IAMHSMPRVALRPNGKS--IACQSLDNCIYVYSAYEKYRQNKKKVFKGYSCSGYSLEVGF 494 Query: 201 SPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGD-IINALCFSPNRYWLCAAT---GPSI 256 SPDG SG G A WD K + L + ++ F P A + SI Sbjct: 495 SPDGRFVFSGDSSGNACFWDWKTCKLMAKLPAHSGPVQSMAFHPQETSKVATSSIVDGSI 554 Query: 257 KIWD 260 K WD Sbjct: 555 KYWD 558 Score = 115 bits (289), Expect = 2e-26, Method: Composition-based stats. Identities = 39/183 (21%), Positives = 71/183 (38%), Gaps = 15/183 (8%) Query: 137 VCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNL-ANCKLKTNHIGHTGYL 195 K+ + H++ +SC+RF P S + ++ S D +K+W + + L GH + Sbjct: 255 PKKHIFTWKGHTKGISCLRFFPISGHLLL-SGSMDNQIKIWEVYHDRSLLRTFQGHARPI 313 Query: 196 NTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCF--SPNRY--WLCAA 251 ++ S DG S D LWD GK L + + N + F P++ +L Sbjct: 314 RDLSFSQDGRSFLSTSFDKTIKLWDTELGKCLNCFNSDRLTNCVKFQVDPDKPNEFLAGT 373 Query: 252 TGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQ 311 I +D+ IV + S+ + +G+ D+ +R W+ Sbjct: 374 ADKRILQFDIRSPDIVQAYDHHL---------GGINSITFLENGKRFVTTSDDSSMRFWE 424 Query: 312 VTI 314 Sbjct: 425 YGT 427 Score = 56.6 bits (135), Expect = 1e-08, Method: Composition-based stats. Identities = 20/97 (20%), Positives = 38/97 (39%), Gaps = 13/97 (13%) Query: 224 GKHLYTLDGGD-IINALCFSP--NRYWLCAATGPSIKIWD-LEGKIIVDELKQEVISTSS 279 KH++T G I+ L F P L + IKIW+ + ++ + Sbjct: 256 KKHIFTWKGHTKGISCLRFFPISGHLLLSGSMDNQIKIWEVYHDRSLLRTFQ-------- 307 Query: 280 KAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGT 316 L++S DG++ + D +++W +G Sbjct: 308 -GHARPIRDLSFSQDGRSFLSTSFDKTIKLWDTELGK 343 Score = 40.1 bits (92), Expect = 0.001, Method: Composition-based stats. Identities = 12/40 (30%), Positives = 18/40 (45%), Gaps = 1/40 (2%) Query: 6 TLRGTLKGHNGWVTQIATTPQFPDMILSAS-RDKTIIMWK 44 L L H+G V +A PQ + ++S D +I W Sbjct: 519 KLMAKLPAHSGPVQSMAFHPQETSKVATSSIVDGSIKYWD 558 >3JRO-A nrPDB Length = 753 Score = 161 bits (406), Expect = 5e-40, Method: Composition-based stats. Identities = 61/248 (24%), Positives = 98/248 (39%), Gaps = 32/248 (12%) Query: 3 EQMTLRGTLKGHNGWVTQIAT-TPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRG 61 E L TL GH G V ++ P+F ++ S S D +++WK E N Q A+ Sbjct: 41 ETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWK----EENGRWSQIAVHA 96 Query: 62 -HSHFVSDVVISSD--GQFALSGSWDGTLRLWDLTTGTTTRRFV--GHTKDVLSVAFSS- 115 HS V+ V + G L S DG + + + TT + H V S +++ Sbjct: 97 VHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPA 156 Query: 116 ------------DNRQIVSGSRDKTIKLWNTLGVCKYTV---QDESHSEWVSCVRFSPNS 160 ++R+ V+G D +K+W + V E HS+WV V +SP Sbjct: 157 TIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTV 216 Query: 161 -SNPIIVSCGWDKLVKVW--NLANCKLKTNHIGHTGY---LNTVTVSPDGSLCASGGKDG 214 + S D+ +W + K + + L + S G++ A G D Sbjct: 217 LLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDN 276 Query: 215 QAMLWDLN 222 + LW N Sbjct: 277 KVTLWKEN 284 Score = 140 bits (352), Expect = 9e-34, Method: Composition-based stats. Identities = 51/280 (18%), Positives = 96/280 (34%), Gaps = 33/280 (11%) Query: 61 GHSHFVSDVVISSDGQFALSGSWDGTLRLWDL--TTGTTTRRFVGHTKDVLSVAFS--SD 116 H+ + D V+ G+ + S D T++++++ T GH V V ++ Sbjct: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKF 66 Query: 117 NRQIVSGSRDKTIKLWNTL-GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVK 175 + S S D + +W G HS V+ V+++P+ P+++ D V Sbjct: 67 GTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVS 126 Query: 176 VWNLANC--KLKTNHIGHTGYLNTVTVSP-------------DGSLCASGGKDGQAMLWD 220 V H +N+ + +P + +GG D +W Sbjct: 127 VVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWK 186 Query: 221 LNEGKHLYTLD-----GGDIINALCFSPN----RYWLCAATGPSIKIWDLEGKIIVDELK 271 N Y L+ D + + +SP Y + + IW + ++ Sbjct: 187 YNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDN----EQGP 242 Query: 272 QEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQ 311 + + P +WS G L DN V +W+ Sbjct: 243 WKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 282 Score = 126 bits (316), Expect = 1e-29, Method: Composition-based stats. Identities = 58/298 (19%), Positives = 106/298 (35%), Gaps = 36/298 (12%) Query: 27 FPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSD--GQFALSGSWD 84 + + + S DKTI ++++ E L GH V V + G S S+D Sbjct: 20 YGKRLATCSSDKTIKIFEV---EGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYD 76 Query: 85 GTLRLWDLTTGTT--TRRFVGHTKDVLSVAFSS--DNRQIVSGSRDKTIKLWNTLGVCKY 140 G + +W G H+ V SV ++ ++ S D + + Sbjct: 77 GKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTT 136 Query: 141 T-VQDESHSEWVSCVRFSP-----------NSSNPIIVSCGWDKLVKVW----NLANCKL 184 + + ++H+ V+ ++P + V+ G D LVK+W + L Sbjct: 137 SPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVL 196 Query: 185 KTNHIGHTGYLNTVTVSPD---GSLCASGGKDGQAMLW--DLNEGKHLYTLDGGDIINAL 239 ++ GH+ ++ V SP S AS +D ++W D +G TL + + Sbjct: 197 ESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDV 256 Query: 240 ----CFSPNRYWLC-AATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWS 292 +S + L + + +W E E EV + TS + Sbjct: 257 LWRASWSLSGNVLALSGGDNKVTLWK-ENLEGKWEPAGEVHQGGGGSGGGGATSKEFD 313 Score = 80.9 bits (198), Expect = 7e-16, Method: Composition-based stats. Identities = 31/158 (19%), Positives = 51/158 (32%), Gaps = 21/158 (13%) Query: 11 LKGHNGWVTQIATTP------------QFPDMILSASRDKTIIMWKLTRDETNYGIPQRA 58 + H V + P + ++ D + +WK D Y + + Sbjct: 141 IDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTY-VLEST 199 Query: 59 LRGHSHFVSDVVISSD---GQFALSGSWDGTLRLW--DLTTGTTTRRFVGHTK---DVLS 110 L GHS +V DV S + S S D T +W D G + + K + Sbjct: 200 LEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWR 259 Query: 111 VAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHS 148 ++S + D + LW K+ E H Sbjct: 260 ASWSLSGNVLALSGGDNKVTLWKENLEGKWEPAGEVHQ 297 Score = 44.3 bits (103), Expect = 7e-05, Method: Composition-based stats. Identities = 12/74 (16%), Positives = 27/74 (36%), Gaps = 9/74 (12%) Query: 245 RYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWS--ADGQTLFAGY 302 + ++ +IKI+++EG + + + + W+ G L + Sbjct: 22 KRLATCSSDKTIKIFEVEG-------ETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCS 74 Query: 303 TDNLVRVWQVTIGT 316 D V +W+ G Sbjct: 75 YDGKVLIWKEENGR 88 Score = 32.0 bits (71), Expect = 0.33, Method: Composition-based stats. Identities = 5/37 (13%), Positives = 13/37 (35%) Query: 277 TSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVT 313 + A G+ L +D +++++V Sbjct: 3 VIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVE 39 >4BH6-A nrPDB Length = 308 Score = 160 bits (405), Expect = 6e-40, Method: Composition-based stats. Identities = 55/252 (21%), Positives = 102/252 (40%), Gaps = 19/252 (7%) Query: 67 SDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRD 126 + + G G +G + ++D+ R GH V ++++ N + SGSRD Sbjct: 66 TSLSWIGAGSHLAVGQANGLVEIYDVMKRKCIRTLSGHIDRVACLSWN--NHVLTSGSRD 123 Query: 127 KTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKT 186 I + + ESH++ V +++ N ++ + S G D +V V+ + Sbjct: 124 HRILHRDVRMPDPFFETIESHTQEVCGLKW--NVADNKLASGGNDNVVHVYEGTSKSPIL 181 Query: 187 NHIGHTGYLNTVTVSPDGS-LCASGG--KDGQAMLWDLNEGKHLYTLDGGDIINALCFSP 243 H + + SP + A+GG D + +W++N + +D G I + +S Sbjct: 182 TFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDIDSGSQICNMVWSK 241 Query: 244 NRYWLCAATGPS---IKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFA 300 N L + G S + +WD + LK + L S DG T+ + Sbjct: 242 NTNELVTSHGYSKYNLTLWDCNSMDPIAILK---------GHSFRVLHLTLSNDGTTVVS 292 Query: 301 GYTDNLVRVWQV 312 G D +R W++ Sbjct: 293 GAGDETLRYWKL 304 Score = 115 bits (289), Expect = 2e-26, Method: Composition-based stats. Identities = 50/217 (23%), Positives = 91/217 (41%), Gaps = 14/217 (6%) Query: 9 GTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSD 68 TL GH V ++ ++ S SRD I L RD + H+ V Sbjct: 98 RTLSGHIDRVACLSWN---NHVLTSGSRDHRI----LHRDVRMPDPFFETIESHTQEVCG 150 Query: 69 VVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVS---GSR 125 + + SG D + +++ T+ + F H V ++A+S R +++ G+ Sbjct: 151 LKWNVADNKLASGGNDNVVHVYEGTSKSPILTFDEHKAAVKAMAWSPHKRGVLATGGGTA 210 Query: 126 DKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDK-LVKVWNLANCKL 184 D+ +K+WN K + D + + +S N +N ++ S G+ K + +W+ + Sbjct: 211 DRRLKIWNVNTSIKMSDIDSGSQ--ICNMVWSKN-TNELVTSHGYSKYNLTLWDCNSMDP 267 Query: 185 KTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDL 221 GH+ + +T+S DG+ SG D W L Sbjct: 268 IAILKGHSFRVLHLTLSNDGTTVVSGAGDETLRYWKL 304 Score = 92.1 bits (227), Expect = 3e-19, Method: Composition-based stats. Identities = 39/253 (15%), Positives = 90/253 (35%), Gaps = 16/253 (6%) Query: 15 NGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSD 74 T ++ + + + ++ + + + R L GH V+ + + Sbjct: 62 ENEYTSLSWIGAGSH-LAVGQANGLVEIYDVMKRK-----CIRTLSGHIDRVACLSW--N 113 Query: 75 GQFALSGSWDGTLRLWDLT-TGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWN 133 SGS D + D+ HT++V + ++ + ++ SG D + ++ Sbjct: 114 NHVLTSGSRDHRILHRDVRMPDPFFETIESHTQEVCGLKWNVADNKLASGGNDNVVHVYE 173 Query: 134 TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCG-WDKLVKVWNLANCKLKTNHIGHT 192 + + H V + +SP+ + G D+ +K+WN+ ++ Sbjct: 174 GTSKS-PILTFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDIDS-G 231 Query: 193 GYLNTVTVSPDGSLCAS--GGKDGQAMLWDLNEGKHLYTLDGGDI-INALCFSPNRYWLC 249 + + S + + + G LWD N + L G + L S + + Sbjct: 232 SQICNMVWSKNTNELVTSHGYSKYNLTLWDCNSMDPIAILKGHSFRVLHLTLSNDGTTVV 291 Query: 250 AATGP-SIKIWDL 261 + G +++ W L Sbjct: 292 SGAGDETLRYWKL 304 Score = 67.0 bits (162), Expect = 1e-11, Method: Composition-based stats. Identities = 26/133 (19%), Positives = 50/133 (37%), Gaps = 10/133 (7%) Query: 10 TLKGHNGWVTQIATTPQFPDMILSAS--RDKTIIMWKLTRDETNYGIPQRALRGHSHFVS 67 T H V +A +P ++ + D+ + +W + I + Sbjct: 182 TFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDIDS------GSQIC 235 Query: 68 DVVISSDGQFALSGS--WDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSR 125 ++V S + ++ L LWD + GH+ VL + S+D +VSG+ Sbjct: 236 NMVWSKNTNELVTSHGYSKYNLTLWDCNSMDPIAILKGHSFRVLHLTLSNDGTTVVSGAG 295 Query: 126 DKTIKLWNTLGVC 138 D+T++ W Sbjct: 296 DETLRYWKLFDKP 308 Score = 47.0 bits (110), Expect = 1e-05, Method: Composition-based stats. Identities = 23/121 (19%), Positives = 47/121 (38%), Gaps = 10/121 (8%) Query: 192 TGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGG-DIINALCFSPNRYWLCA 250 +++ GS A G +G ++D+ + K + TL G D + L ++ N Sbjct: 62 ENEYTSLSWIGAGSHLAVGQANGLVEIYDVMKRKCIRTLSGHIDRVACLSWN-NHVLTSG 120 Query: 251 ATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVW 310 + I D+ + + ++ + L W+ L +G DN+V V+ Sbjct: 121 SRDHRILHRDVR--------MPDPFFETIESHTQEVCGLKWNVADNKLASGGNDNVVHVY 172 Query: 311 Q 311 + Sbjct: 173 E 173 >5K0Y-T nrPDB Length = 329 Score = 160 bits (404), Expect = 8e-40, Method: Composition-based stats. Identities = 58/317 (18%), Positives = 115/317 (36%), Gaps = 29/317 (9%) Query: 11 LKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVV 70 L+GH +TQI + D++ + ++D + +W E GH+ V V Sbjct: 6 LQGHERSITQIKYNRE-GDLLFTVAKDPIVNVWYSVNGER-----LGTYMGHTGAVWCVD 59 Query: 71 ISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKT-- 128 D + L+GS D + RLWD TG V + F I+ + + Sbjct: 60 ADWDTKHVLTGSADNSCRLWDCETGKQLALLK-TNSAVRTCGFDFGGNIIMFSTDKQMGY 118 Query: 129 ---IKLWNTLGVCK-----YTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLA 180 + ++ + ++ + ++ + P I++ + ++ Sbjct: 119 QCFVSFFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGP--LGECIIAGHESGELNQYSAK 176 Query: 181 NCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALC 240 + ++ N H+ +N + +S + ++ + KD A L+D +H T Sbjct: 177 SGEVLVNVKEHSRQINDIQLSREMTMFVTASKDNTAKLFDSTTLEHQKTFRTEPPRELAA 236 Query: 241 FSPNRYWLCAATGP--------SIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWS 292 SPN + G S +I E + ++E K S+A+ Sbjct: 237 LSPNYEHVVVGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRV--KGHFGPINSVAFH 294 Query: 293 ADGQTLFAGYTDNLVRV 309 DG++ +G D VR+ Sbjct: 295 PDGKSYSSGGEDGYVRI 311 Score = 99.4 bits (246), Expect = 2e-21, Method: Composition-based stats. Identities = 50/270 (18%), Positives = 88/270 (32%), Gaps = 64/270 (23%) Query: 9 GTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRAL--------- 59 GT GH G V + +L+ S D + +W + + + Sbjct: 46 GTYMGHTGAVWCVDAD-WDTKHVLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGFDFG 104 Query: 60 -----------RGHSHFVS---------------------------DVVISSDGQFALSG 81 G+ FVS V G+ ++G Sbjct: 105 GNIIMFSTDKQMGYQCFVSFFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAG 164 Query: 82 SWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLG-VCKY 140 G L + +G H++ + + S + V+ S+D T KL+++ + Sbjct: 165 HESGELNQYSAKSGEVLVNVKEHSRQINDIQLSREMTMFVTASKDNTAKLFDSTTLEHQK 224 Query: 141 TVQDESHSEWVSCVRFSPNSSNPIIVSC--GWDKL----------VKVWNLANCKLKTNH 188 T + E E SPN + ++ D + ++LA + Sbjct: 225 TFRTEPPREL---AALSPNYEHVVVGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRV 281 Query: 189 IGHTGYLNTVTVSPDGSLCASGGKDGQAML 218 GH G +N+V PDG +SGG+DG + Sbjct: 282 KGHFGPINSVAFHPDGKSYSSGGEDGYVRI 311 Score = 86.7 bits (213), Expect = 1e-17, Method: Composition-based stats. Identities = 33/218 (15%), Positives = 64/218 (29%), Gaps = 47/218 (21%) Query: 142 VQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVS 201 + + H ++ +++ N ++ + D +V VW N + ++GHTG + V Sbjct: 4 ILLQGHERSITQIKY--NREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDAD 61 Query: 202 PDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATGPS------ 255 D +G D LWD GK L L + F + +T Sbjct: 62 WDTKHVLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGFDFGGNIIMFSTDKQMGYQCF 121 Query: 256 IKIWDLEGKIIVDELKQEV---------------------------------------IS 276 + +DL +D + + + Sbjct: 122 VSFFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGEVL 181 Query: 277 TSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTI 314 + K Q + S + DN +++ T Sbjct: 182 VNVKEHSRQINDIQLSREMTMFVTASKDNTAKLFDSTT 219 Score = 51.2 bits (121), Expect = 6e-07, Method: Composition-based stats. Identities = 30/138 (21%), Positives = 49/138 (35%), Gaps = 27/138 (19%) Query: 12 KGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGI---PQRALRGHSHFVSD 68 K H+ + I + + M ++AS+D T ++ T E P R L Sbjct: 185 KEHSRQINDIQLSREMT-MFVTASKDNTAKLFDSTTLEHQKTFRTEPPREL--------- 234 Query: 69 VVISSDGQFALSGS----WDGT----------LRLWDLTTGTTTRRFVGHTKDVLSVAFS 114 +S + + + G D T R + L R GH + SVAF Sbjct: 235 AALSPNYEHVVVGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFH 294 Query: 115 SDNRQIVSGSRDKTIKLW 132 D + SG D +++ Sbjct: 295 PDGKSYSSGGEDGYVRIH 312 Score = 50.8 bits (120), Expect = 8e-07, Method: Composition-based stats. Identities = 14/87 (16%), Positives = 26/87 (29%), Gaps = 10/87 (11%) Query: 232 GGDIINALCFSPNRYWL-CAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLA 290 I + ++ L A P + +W + E + T + Sbjct: 9 HERSITQIKYNREGDLLFTVAKDPIVNVW--------YSVNGERLGTYM-GHTGAVWCVD 59 Query: 291 WSADGQTLFAGYTDNLVRVWQVTIGTR 317 D + + G DN R+W G + Sbjct: 60 ADWDTKHVLTGSADNSCRLWDCETGKQ 86 Score = 31.6 bits (70), Expect = 0.45, Method: Composition-based stats. Identities = 10/38 (26%), Positives = 16/38 (42%) Query: 280 KAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGTR 317 + T + ++ +G LF D +V VW G R Sbjct: 7 QGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGER 44 >4L9O-A nrPDB Length = 349 Score = 157 bits (396), Expect = 8e-39, Method: Composition-based stats. Identities = 60/239 (25%), Positives = 98/239 (41%), Gaps = 22/239 (9%) Query: 3 EQMTLRGTLKGHNGWVTQIAT-TPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRG 61 E L TL GH G V Q+A P+F ++ S S D +++WK N Sbjct: 101 ENQRLVETLIGHEGPVWQVAWAHPKFGVILASCSYDGKVLIWKEDNGVWNKVAEHSV--- 157 Query: 62 HSHFVSDVVISSD--GQFALSGSWDGTLRLWDLTTGTTTRR--FVGHTKDVLSVAFSS-- 115 H V+ V + G L S DG + + + G GH V + +++ Sbjct: 158 HQASVNSVSWAPHEYGPVLLCASSDGKISIVEFKDGGALEPIVIQGHAIGVNAASWAPIS 217 Query: 116 ---DNRQIVSGSRDKTIKLWNTLGVCKYTVQDE---SHSEWVSCVRFSPNS-SNPIIVSC 168 + R+ VSG D +K+W K +++E HS+WV V +SP+ S I + Sbjct: 218 LPDNTRRFVSGGCDNLVKIWRYDDAAKTFIEEEAFQGHSDWVRDVAWSPSRLSKSYIATA 277 Query: 169 GWDKLVKVW--NLANCKLKTNHIGHTGYL---NTVTVSPDGSLCASGGKDGQAMLWDLN 222 D+ V +W + + K + + + + S G++ A G D + LW N Sbjct: 278 SQDRTVLIWTKDGKSNKWEKQPLTKEKFPDVCWRASWSLSGNVLAISGGDNKVTLWKEN 336 Score = 144 bits (363), Expect = 4e-35, Method: Composition-based stats. Identities = 56/275 (20%), Positives = 105/275 (38%), Gaps = 25/275 (9%) Query: 61 GHSHFVSDVVISSDGQFALSGSWDGTLRLWDL--TTGTTTRRFVGHTKDVLSVAFS--SD 116 H + D V+ G+ + S D T++++++ +GH V VA++ Sbjct: 67 AHDDLIHDAVLDYYGRRLATCSSDKTIKIFEIDGENQRLVETLIGHEGPVWQVAWAHPKF 126 Query: 117 NRQIVSGSRDKTIKLWN-TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVK 175 + S S D + +W GV + H V+ V ++P+ P+++ D + Sbjct: 127 GVILASCSYDGKVLIWKEDNGVWNKVAEHSVHQASVNSVSWAPHEYGPVLLCASSDGKIS 186 Query: 176 VWNLANCKLKT--NHIGHTGYLNTVTVSP-----DGSLCASGGKDGQAMLWDLNEGKHLY 228 + + GH +N + +P + SGG D +W ++ + Sbjct: 187 IVEFKDGGALEPIVIQGHAIGVNAASWAPISLPDNTRRFVSGGCDNLVKIWRYDDAAKTF 246 Query: 229 TLD-----GGDIINALCFSPNR----YWLCAATGPSIKIWDLEGKIIVDELKQEVISTSS 279 + D + + +SP+R Y A+ ++ IW +GK K E + Sbjct: 247 IEEEAFQGHSDWVRDVAWSPSRLSKSYIATASQDRTVLIWTKDGKSN----KWEKQPLTK 302 Query: 280 KAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTI 314 + P C +WS G L DN V +W+ I Sbjct: 303 EKFPDVCWRASWSLSGNVLAISGGDNKVTLWKENI 337 Score = 118 bits (296), Expect = 3e-27, Method: Composition-based stats. Identities = 52/257 (20%), Positives = 95/257 (36%), Gaps = 27/257 (10%) Query: 27 FPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSD--GQFALSGSWD 84 + + + S DKTI ++++ + L GH V V + G S S+D Sbjct: 80 YGRRLATCSSDKTIKIFEIDGENQR---LVETLIGHEGPVWQVAWAHPKFGVILASCSYD 136 Query: 85 GTLRLWDLTTGTTTRRFVG--HTKDVLSVAFSS--DNRQIVSGSRDKTIKLWNTL-GVCK 139 G + +W G + H V SV+++ ++ S D I + G Sbjct: 137 GKVLIWKEDNGVWNKVAEHSVHQASVNSVSWAPHEYGPVLLCASSDGKISIVEFKDGGAL 196 Query: 140 YTVQDESHSEWVSCVRFSPNS---SNPIIVSCGWDKLVKVW----NLANCKLKTNHIGHT 192 + + H+ V+ ++P S + VS G D LVK+W + GH+ Sbjct: 197 EPIVIQGHAIGVNAASWAPISLPDNTRRFVSGGCDNLVKIWRYDDAAKTFIEEEAFQGHS 256 Query: 193 GYLNTVTVSP---DGSLCASGGKDGQAMLW------DLNEGKHLYTLDGGDIINALCFSP 243 ++ V SP S A+ +D ++W + E + L D+ +S Sbjct: 257 DWVRDVAWSPSRLSKSYIATASQDRTVLIWTKDGKSNKWEKQPLTKEKFPDVCWRASWSL 316 Query: 244 NRYWLC-AATGPSIKIW 259 + L + + +W Sbjct: 317 SGNVLAISGGDNKVTLW 333 Score = 87.4 bits (215), Expect = 7e-18, Method: Composition-based stats. Identities = 39/183 (21%), Positives = 77/183 (42%), Gaps = 16/183 (8%) Query: 146 SHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVW--NLANCKLKTNHIGHTGYLNTVTV-SP 202 +H + + + + +C DK +K++ + N +L IGH G + V P Sbjct: 67 AHDDLIHDAVL--DYYGRRLATCSSDKTIKIFEIDGENQRLVETLIGHEGPVWQVAWAHP 124 Query: 203 D-GSLCASGGKDGQAMLWDLNEG---KHLYTLDGGDIINALCFSPNRY---WLCAATGPS 255 G + AS DG+ ++W + G K +N++ ++P+ Y LCA++ Sbjct: 125 KFGVILASCSYDGKVLIWKEDNGVWNKVAEHSVHQASVNSVSWAPHEYGPVLLCASSDGK 184 Query: 256 IKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADG-QTLFAGYTDNLVRVWQVTI 314 I I + + ++ + + + A SL D + +G DNLV++W+ Sbjct: 185 ISIVEFKDGGALEPIVIQGHAIGVNAASWAPISL---PDNTRRFVSGGCDNLVKIWRYDD 241 Query: 315 GTR 317 + Sbjct: 242 AAK 244 Score = 30.4 bits (67), Expect = 0.92, Method: Composition-based stats. Identities = 5/37 (13%), Positives = 13/37 (35%) Query: 277 TSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVT 313 T A G+ L +D ++++++ Sbjct: 63 TIGNAHDDLIHDAVLDYYGRRLATCSSDKTIKIFEID 99 >5MWJ-A nrPDB Length = 337 Score = 156 bits (393), Expect = 2e-38, Method: Composition-based stats. Identities = 60/275 (21%), Positives = 105/275 (38%), Gaps = 20/275 (7%) Query: 51 NYGIPQRALR----GHSHFVSDVVISSDGQFALSGSWDGTLRLWDLT-----TGTTTRRF 101 GIP+ A + H V V IS+ + +G G +++WD++ + + Sbjct: 35 GPGIPRHARQINTLNHGEVVCAVTISNPTRHVYTGG-KGCVKVWDISHPGNKSPVSQLDC 93 Query: 102 VGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSS 161 + + S D ++ G T+ +W+ L ++ E S +C + + Sbjct: 94 LNRDNYIRSCKLLPDGCTLIVGGEASTLSIWD-LAAPTPRIKAELTSSAPACYALAISPD 152 Query: 162 NPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDL 221 + + SC D + VW+L N L GHT + + +S DG+ +GG D WDL Sbjct: 153 SKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDL 212 Query: 222 NEGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKA 281 EG+ L D I +L + P WL +E + + Sbjct: 213 REGRQLQQHDFTSQIFSLGYCPTGEWLAVG---------MESSNVEVLHVNKPDKYQLHL 263 Query: 282 EPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGT 316 SL ++ G+ + DNL+ W+ G Sbjct: 264 HESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGA 298 Score = 116 bits (291), Expect = 1e-26, Method: Composition-based stats. Identities = 50/302 (16%), Positives = 103/302 (34%), Gaps = 19/302 (6%) Query: 14 HNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISS 73 H V + + + + + + +W ++ + Q +++ + Sbjct: 50 HGEVVCAVTISNPTRH-VYTGGKGC-VKVWDISHPGNKSPVSQLDCLNRDNYIRSCKLLP 107 Query: 74 DGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLS--VAFSSDNRQIVSGSRDKTIKL 131 DG + G TL +WDL T + + +A S D++ S D I + Sbjct: 108 DGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAV 167 Query: 132 WNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGH 191 W+ L Q + H++ SC+ S + + + + G D V+ W+L + H Sbjct: 168 WD-LHNQTLVRQFQGHTDGASCIDISNDGTK--LWTGGLDNTVRSWDLREGRQLQQHD-F 223 Query: 192 TGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYW-LCA 250 T + ++ P G A G + + +N+ + +L F+ W + Sbjct: 224 TSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDKYQLHLHESCVLSLKFAYCGKWFVST 283 Query: 251 ATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVW 310 + W + + K+ S S D + + G D V+ Sbjct: 284 GKDNLLNAWRTPYGASIFQSKE----------SSSVLSCDISVDDKYIVTGSGDKKATVY 333 Query: 311 QV 312 +V Sbjct: 334 EV 335 Score = 91.3 bits (225), Expect = 5e-19, Method: Composition-based stats. Identities = 39/180 (21%), Positives = 67/180 (37%), Gaps = 21/180 (11%) Query: 147 HSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNL-----ANCKLKTNHIGHTGYLNTVTVS 201 H E V V S + + + G VKVW++ + + + + Y+ + + Sbjct: 50 HGEVVCAVTIS--NPTRHVYTGGK-GCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCKLL 106 Query: 202 PDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDI---INALCFSPNRYW-LCAATGPSIK 257 PDG GG+ +WDL + AL SP+ + +I Sbjct: 107 PDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIA 166 Query: 258 IWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGTR 317 +WDL + +V + + + + S DG L+ G DN VR W + G + Sbjct: 167 VWDLHNQTLVRQFQ---------GHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQ 217 Score = 80.9 bits (198), Expect = 7e-16, Method: Composition-based stats. Identities = 30/180 (16%), Positives = 59/180 (32%), Gaps = 16/180 (8%) Query: 2 TEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRG 61 TL +GH + I + + + D T+ W L R L+ Sbjct: 170 LHNQTLVRQFQGHTDGASCIDIS-NDGTKLWTGGLDNTVRSWDLREG--------RQLQQ 220 Query: 62 H--SHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQ 119 H + + + G++ G + + + + H VLS+ F+ + Sbjct: 221 HDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHV-NKPDKYQLHLHESCVLSLKFAYCGKW 279 Query: 120 IVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNL 179 VS +D + W ++ S V + + + IV+ DK V+ + Sbjct: 280 FVSTGKDNLLNAW--RTPYGASIFQSKESSSV--LSCDISVDDKYIVTGSGDKKATVYEV 335 >5OQL-J nrPDB Length = 912 Score = 156 bits (393), Expect = 2e-38, Method: Composition-based stats. Identities = 64/254 (25%), Positives = 96/254 (37%), Gaps = 39/254 (15%) Query: 4 QMTLRGTLKGHNGWVTQIAT-------------TPQF--PDMILSASRDKTIIMWKLTRD 48 T GH V +A P P ++S S+D+ + + R Sbjct: 468 SYTCYAVFTGHLESVGAVALPKVVPPANSEAFKNPLDHPPAFLISGSQDRFVQKRDIPRQ 527 Query: 49 ETNYGIPQRALR--GHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTK 106 G +LR H ++ + IS +G+ S S D T+++WD+ GH + Sbjct: 528 LQKGGKLTSSLRRLAHDKDINALDISPNGKLFASASQDKTVKIWDVEKLEVQGILRGHKR 587 Query: 107 DVLSVAFSSDNRQIV--------------SGSRDKTIKLWNTLGVCKYTVQDESHSEWVS 152 V +V F+ N ++ +GS DKTIKLWN L E HS V Sbjct: 588 GVWTVRFAPLNTPVIQGEQGSVSGRGVVLTGSGDKTIKLWN-LSDYTCIRTFEGHSHNVL 646 Query: 153 CVRF-------SPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGS 205 V + S + S G D LVKVW+ + + H L T+ V + Sbjct: 647 KVVWLHISRDDSITKTKVQFASAGADTLVKVWDANTGETECTLDNHEDRLWTLAVHSKTN 706 Query: 206 LCASGGKDGQAMLW 219 + AS G D + W Sbjct: 707 ILASAGSDSKVTFW 720 Score = 140 bits (353), Expect = 7e-34, Method: Composition-based stats. Identities = 62/316 (19%), Positives = 120/316 (37%), Gaps = 62/316 (19%) Query: 47 RDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLT----TGTTTRRFV 102 R + +G L+GH V + + G + SGS D T RLW + + T F Sbjct: 417 RSGSYFGHDVALLKGHEDIVMSLDVDWSGHWIASGSKDNTARLWRVDPANNSYTCYAVFT 476 Query: 103 GHTKDVLSVAF-------------SSDNR---QIVSGSRDKTIKLWNTLGVCKY------ 140 GH + V +VA + + ++SGS+D+ ++ + + Sbjct: 477 GHLESVGAVALPKVVPPANSEAFKNPLDHPPAFLISGSQDRFVQKRDIPRQLQKGGKLTS 536 Query: 141 TVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTV 200 +++ +H + ++ + SPN + S DK VK+W++ +++ GH + TV Sbjct: 537 SLRRLAHDKDINALDISPNG--KLFASASQDKTVKIWDVEKLEVQGILRGHKRGVWTVRF 594 Query: 201 SP---------DGSL-----CASGGKDGQAMLWDLNEGKHLYTLDGGD--IINALCFSPN 244 +P GS+ +G D LW+L++ + T +G ++ + + Sbjct: 595 APLNTPVIQGEQGSVSGRGVVLTGSGDKTIKLWNLSDYTCIRTFEGHSHNVLKVVWLHIS 654 Query: 245 RY---------WLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADG 295 R + A +K+WD L + +LA + Sbjct: 655 RDDSITKTKVQFASAGADTLVKVWDANTGETECTLDN---------HEDRLWTLAVHSKT 705 Query: 296 QTLFAGYTDNLVRVWQ 311 L + +D+ V W+ Sbjct: 706 NILASAGSDSKVTFWR 721 Score = 137 bits (346), Expect = 5e-33, Method: Composition-based stats. Identities = 69/297 (23%), Positives = 107/297 (36%), Gaps = 49/297 (16%) Query: 9 GTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSD 68 LKGH V + I S S+D T +W++ N GH V Sbjct: 427 ALLKGHEDIVMSLDVD-WSGHWIASGSKDNTARLWRVDPAN-NSYTCYAVFTGHLESVGA 484 Query: 69 VVISS--------------DGQ--FALSGSWDGTLRLWD----LTTGTTTRRF---VGHT 105 V + D F +SGS D ++ D L G + H Sbjct: 485 VALPKVVPPANSEAFKNPLDHPPAFLISGSQDRFVQKRDIPRQLQKGGKLTSSLRRLAHD 544 Query: 106 KDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPN------ 159 KD+ ++ S + + S S+DKT+K+W+ + + H V VRF+P Sbjct: 545 KDINALDISPNGKLFASASQDKTVKIWDVEKLEVQGI-LRGHKRGVWTVRFAPLNTPVIQ 603 Query: 160 ------SSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTV---SPDGSL---- 206 S ++++ DK +K+WNL++ GH+ + V S D S+ Sbjct: 604 GEQGSVSGRGVVLTGSGDKTIKLWNLSDYTCIRTFEGHSHNVLKVVWLHISRDDSITKTK 663 Query: 207 --CASGGKDGQAMLWDLNEGKHLYTLDGGDI--INALCFSPNRYWLCAATGPSIKIW 259 AS G D +WD N G+ TLD + S A + + W Sbjct: 664 VQFASAGADTLVKVWDANTGETECTLDNHEDRLWTLAVHSKTNILASAGSDSKVTFW 720 Score = 124 bits (311), Expect = 5e-29, Method: Composition-based stats. Identities = 68/363 (18%), Positives = 120/363 (33%), Gaps = 64/363 (17%) Query: 6 TLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHF 65 + + H V IA +P+ +LS SRDKT+ +W L RD G P Sbjct: 223 DPKRKKEAHESNVQCIAYSPEQ-HALLSGSRDKTMTLW-LWRDGIWQGTPMLRHE----L 276 Query: 66 VSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKD---VLSVAFSSDNRQIVS 122 + V ++G++ S G LR+WD TT + + +LS + I+ Sbjct: 277 LESVGFLNEGKWMYSAGTSGVLRIWDTTTHHEITKKQDAKSEGEAILSAVSLPERSLILC 336 Query: 123 GSRDKTIKLWNTLGVCKYTVQDES------------HSEWVSCVRFSPNSSNPIIVSCGW 170 D T+ L+ E H E + P+ S I + Sbjct: 337 AQADFTLVLYRVPSPADVVSSSEGILLEPFRRISGTHDEILDLTYILPDQSMMAIATNSE 396 Query: 171 DKLVKVWNLANCKLKTN-----------------HIGHTGYLNTVTVSPDGSLCASGGKD 213 D +++ ++ + + + GH + ++ V G ASG KD Sbjct: 397 D--IRIVSVKDAQAYSEDNAECRSGSYFGHDVALLKGHEDIVMSLDVDWSGHWIASGSKD 454 Query: 214 GQAMLWDL----NEGKHLYTLDGG-------------DIINALCF-----SPNRYWLCAA 251 A LW + N G N+ F P + + + Sbjct: 455 NTARLWRVDPANNSYTCYAVFTGHLESVGAVALPKVVPPANSEAFKNPLDHPPAFLISGS 514 Query: 252 TGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQ 311 ++ D+ + + + + S A +L S +G+ + D V++W Sbjct: 515 QDRFVQKRDIPRQ--LQKGGKLTSSLRRLAHDKDINALDISPNGKLFASASQDKTVKIWD 572 Query: 312 VTI 314 V Sbjct: 573 VEK 575 Score = 117 bits (293), Expect = 6e-27, Method: Composition-based stats. Identities = 55/329 (16%), Positives = 98/329 (29%), Gaps = 58/329 (17%) Query: 45 LTRDETNYGIPQRALRG-HSHFVSDVVISSDGQFALSGSWDGTLRLWDLTT--------- 94 ++ E P R + G H + I D + +R+ + Sbjct: 355 VSSSEGILLEPFRRISGTHDEILDLTYILPDQSMMAIATNSEDIRIVSVKDAQAYSEDNA 414 Query: 95 --------GTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDE- 145 G GH V+S+ I SGS+D T +LW Sbjct: 415 ECRSGSYFGHDVALLKGHEDIVMSLDVDWSGHWIASGSKDNTARLWRVDPANNSYTCYAV 474 Query: 146 --SHSEWVSCVRFSP--------------NSSNPIIVSCGWDKLVKVWNLANCKLK---- 185 H E V V + ++S D+ V+ ++ K Sbjct: 475 FTGHLESVGAVALPKVVPPANSEAFKNPLDHPPAFLISGSQDRFVQKRDIPRQLQKGGKL 534 Query: 186 ---TNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGD-IINALCF 241 + H +N + +SP+G L AS +D +WD+ + + L G + + F Sbjct: 535 TSSLRRLAHDKDINALDISPNGKLFASASQDKTVKIWDVEKLEVQGILRGHKRGVWTVRF 594 Query: 242 SP---------------NRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQC 286 +P L + +IK+W+L + + + Sbjct: 595 APLNTPVIQGEQGSVSGRGVVLTGSGDKTIKLWNLSDYTCIRTFEGHSHNVLKVVWLHIS 654 Query: 287 TSLAWSADGQTLFAGYTDNLVRVWQVTIG 315 + + + D LV+VW G Sbjct: 655 RDDSITKTKVQFASAGADTLVKVWDANTG 683 Score = 109 bits (272), Expect = 2e-24, Method: Composition-based stats. Identities = 58/349 (16%), Positives = 121/349 (34%), Gaps = 55/349 (15%) Query: 11 LKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRD---ETNYGIPQRALRGHSHFVS 67 ++G ++ + TP +I+ SR T+ ++ L ++ R + H+ V Sbjct: 57 IQGDGEPISTLTITPSGSHLIV-CSRSLTMRIYSLAISPDYDSVEPTLVRTTKPHATPVV 115 Query: 68 DVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAF-------------- 113 + + +G+ DG +++WD+ G T G + V ++ F Sbjct: 116 VLAVDRTSTLLATGAADGAIKIWDIIGGYVTHTVSGPSVLVSALHFFEIAVTAESQSSNK 175 Query: 114 ----------SSDNRQIVS------GSRDKTIKLWNTLG------VCKYTVQDESHSEWV 151 + D +I S G++D I++++ + E+H V Sbjct: 176 KPKKGSRKGQNDDADEIASRFRLAWGTQDGRIRIFDLYKRTTTPVYADPKRKKEAHESNV 235 Query: 152 SCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGG 211 C+ +SP ++S DK + +W + + + L +V +G S G Sbjct: 236 QCIAYSPEQHA--LLSGSRDKTMTLWLWRDGIWQGTPMLRHELLESVGFLNEGKWMYSAG 293 Query: 212 KDGQAMLWDLN-----EGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIW------D 260 G +WD K +G I++A+ LCA ++ ++ D Sbjct: 294 TSGVLRIWDTTTHHEITKKQDAKSEGEAILSAVSLPERSLILCAQADFTLVLYRVPSPAD 353 Query: 261 LEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRV 309 + L+ + + E T + + D +R+ Sbjct: 354 VVSSSEGILLEPFRRISGTHDEILDLTYILPDQSMMAIATNSED--IRI 400 Score = 103 bits (257), Expect = 1e-22, Method: Composition-based stats. Identities = 55/309 (17%), Positives = 104/309 (33%), Gaps = 52/309 (16%) Query: 49 ETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRL--------WDLTTGTTTRR 100 E N G ++G +S + I+ G + S T+R+ +D T R Sbjct: 47 ELNTGKRLAEIQGDGEPISTLTITPSGSHLIVCSRSLTMRIYSLAISPDYDSVEPTLVRT 106 Query: 101 FVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRF---- 156 H V+ +A + + +G+ D IK+W+ +G T S VS + F Sbjct: 107 TKPHATPVVVLAVDRTSTLLATGAADGAIKIWDIIGGY-VTHTVSGPSVLVSALHFFEIA 165 Query: 157 ------------------SPNSSNPIIVS------CGWDKLVKVWNLANCK-------LK 185 N I S D +++++L K Sbjct: 166 VTAESQSSNKKPKKGSRKGQNDDADEIASRFRLAWGTQDGRIRIFDLYKRTTTPVYADPK 225 Query: 186 TNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYT-LDGGDIINALCFSPN 244 H + + SP+ SG +D LW +G T + +++ ++ F Sbjct: 226 RKKEAHESNVQCIAYSPEQHALLSGSRDKTMTLWLWRDGIWQGTPMLRHELLESVGFLNE 285 Query: 245 RYWL-CAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYT 303 W+ A T ++IWD + + + +K+E S + + Sbjct: 286 GKWMYSAGTSGVLRIWDTTTHHEITKKQD------AKSEGEAILSAVSLPERSLILCAQA 339 Query: 304 DNLVRVWQV 312 D + +++V Sbjct: 340 DFTLVLYRV 348 Score = 102 bits (255), Expect = 2e-22, Method: Composition-based stats. Identities = 50/290 (17%), Positives = 96/290 (33%), Gaps = 31/290 (10%) Query: 31 ILSASRDKTIIMWKLTR--DETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLR 88 + ++D I ++ L + Y P+R H V + S + LSGS D T+ Sbjct: 198 LAWGTQDGRIRIFDLYKRTTTPVYADPKRKKEAHESNVQCIAYSPEQHALLSGSRDKTMT 257 Query: 89 LWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHS 148 LW G + + + SV F ++ + + S +++W+T + T + ++ S Sbjct: 258 LWLWRDGIWQGTPMLRHELLESVGFLNEGKWMYSAGTSGVLRIWDTTTHHEITKKQDAKS 317 Query: 149 EWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLC- 207 E + + +I+ D + ++ + + V S +G L Sbjct: 318 EGEAILSAVSLPERSLILCAQADFTLVLYRVPS-------------PADVVSSSEGILLE 364 Query: 208 ----ASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEG 263 SG D L Y L ++ S + + + + + Sbjct: 365 PFRRISGTHDEILDL--------TYILPDQSMMAIATNSEDIRIVSVKDAQA---YSEDN 413 Query: 264 KIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVT 313 K SL G + +G DN R+W+V Sbjct: 414 AECRSGSYFGHDVALLKGHEDIVMSLDVDWSGHWIASGSKDNTARLWRVD 463 Score = 94.4 bits (233), Expect = 6e-20, Method: Composition-based stats. Identities = 36/152 (23%), Positives = 56/152 (36%), Gaps = 27/152 (17%) Query: 3 EQMTLRGTLKGHNGWVTQIATTPQFP-------------DMILSASRDKTIIMWKLTRDE 49 E++ ++G L+GH V + P ++L+ S DKTI +W L+ Sbjct: 574 EKLEVQGILRGHKRGVWTVRFAPLNTPVIQGEQGSVSGRGVVLTGSGDKTIKLWNLSD-- 631 Query: 50 TNYGIPQRALRGHSHFVSDVVISSDGQ---------FALSGSWDGTLRLWDLTTGTTTRR 100 R GHSH V VV + S D +++WD TG T Sbjct: 632 ---YTCIRTFEGHSHNVLKVVWLHISRDDSITKTKVQFASAGADTLVKVWDANTGETECT 688 Query: 101 FVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLW 132 H + ++A S + S D + W Sbjct: 689 LDNHEDRLWTLAVHSKTNILASAGSDSKVTFW 720 Score = 72.8 bits (177), Expect = 2e-13, Method: Composition-based stats. Identities = 35/253 (13%), Positives = 86/253 (33%), Gaps = 28/253 (11%) Query: 68 DVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDK 127 V + + + S + + L +L TG G + + ++ + ++ SR Sbjct: 25 SVALENGARILASTLGENAI-LTELNTGKRLAEIQGDGEPISTLTITPSGSHLIVCSRSL 83 Query: 128 TIKLWNTLGVCKY-------TVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLA 180 T+++++ Y + H+ V V + + ++ ++ + D +K+W++ Sbjct: 84 TMRIYSLAISPDYDSVEPTLVRTTKPHATPV--VVLAVDRTSTLLATGAADGAIKIWDII 141 Query: 181 NCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINA-- 238 + G + ++ + S + + +G D D I + Sbjct: 142 GGYVTHTVSGPSVLVSALHFFEIAVTAESQSSNKKPK-----KGSRKGQNDDADEIASRF 196 Query: 239 -LCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQT 297 L + I+I+DL + +A +A+S + Sbjct: 197 RLAW--------GTQDGRIRIFDLYKRTTTPVYADPKR--KKEAHESNVQCIAYSPEQHA 246 Query: 298 LFAGYTDNLVRVW 310 L +G D + +W Sbjct: 247 LLSGSRDKTMTLW 259 Score = 58.2 bits (139), Expect = 5e-09, Method: Composition-based stats. Identities = 39/214 (18%), Positives = 77/214 (35%), Gaps = 33/214 (15%) Query: 110 SVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCG 169 SVA + R + S + I L K + + E +S + +P+ S+ I+ S Sbjct: 25 SVALENGARILASTLGENAIL--TELNTGKRLAEIQGDGEPISTLTITPSGSHLIVCSRS 82 Query: 170 WDKLVKVWNLA--------NCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDL 221 +++++LA L H + + V +L A+G DG +WD+ Sbjct: 83 L--TMRIYSLAISPDYDSVEPTLVRTTKPHATPVVVLAVDRTSTLLATGAADGAIKIWDI 140 Query: 222 NEGKHLYTLDGGDI-INALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSK 280 G +T+ G + ++AL F +++ ++ S K Sbjct: 141 IGGYVTHTVSGPSVLVSALHF-----------------FEIAVTAESQSSNKKPKKGSRK 183 Query: 281 AEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTI 314 + +A L G D +R++ + Sbjct: 184 GQNDDADEIASRF---RLAWGTQDGRIRIFDLYK 214 Score = 53.9 bits (128), Expect = 8e-08, Method: Composition-based stats. Identities = 25/115 (21%), Positives = 51/115 (44%), Gaps = 3/115 (2%) Query: 203 DGSLCASGGKDGQAMLWDLNEGKHLYTLDG-GDIINALCFSPNR-YWLCAATGPSIKIWD 260 +G+ + A+L +LN GK L + G G+ I+ L +P+ + + + +++I+ Sbjct: 30 NGARILASTLGENAILTELNTGKRLAEIQGDGEPISTLTITPSGSHLIVCSRSLTMRIYS 89 Query: 261 LEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIG 315 L D ++ ++ T+ K LA L G D +++W + G Sbjct: 90 LAISPDYDSVEPTLVRTT-KPHATPVVVLAVDRTSTLLATGAADGAIKIWDIIGG 143 Score = 30.0 bits (66), Expect = 1.3, Method: Composition-based stats. Identities = 14/51 (27%), Positives = 22/51 (43%), Gaps = 1/51 (1%) Query: 10 TLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALR 60 TL H + +A +++ SA D + W+ T ET Q AL+ Sbjct: 688 TLDNHEDRLWTLAVH-SKTNILASAGSDSKVTFWRDTTAETQAAAAQAALK 737 >6J6H-n nrPDB Length = 455 Score = 153 bits (386), Expect = 9e-38, Method: Composition-based stats. Identities = 59/269 (21%), Positives = 113/269 (42%), Gaps = 16/269 (5%) Query: 53 GIPQRALR---GHSHFVSDVVISS-DGQFALSGSWDGTLRLWDLTTG-TTTRRFVGHTKD 107 +P++ +R GH + + G LSG D T+++WD R F GH K Sbjct: 149 YLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKP 208 Query: 108 VLSVAFSSDNRQIVSGSRDKTIKLWNT-LGVCKYTVQDESHSEWVSCVRFSPNSSNPIIV 166 + ++ F+ D + +S S D+++K+W+T G K + + + V P + + IV Sbjct: 209 IKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHL---NSTPADVESRPTNPHEFIV 265 Query: 167 SCGWDKLVKVWN--LANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWD--LN 222 K++ + N L + H + + PDGS S +D +W+ +N Sbjct: 266 GLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQIN 325 Query: 223 EGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAE 282 + + L P++ + CA + + +I+ K +++ S A Sbjct: 326 VPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDN-RIYSFSLKPKYKRHPKKIFKGHSSAG 384 Query: 283 PPQCTSLAWSADGQTLFAGYTDNLVRVWQ 311 SLA+S DG+ + +G + + + W Sbjct: 385 --YGISLAFSGDGRYICSGDSKSRLFTWD 411 Score = 135 bits (341), Expect = 2e-32, Method: Composition-based stats. Identities = 58/306 (18%), Positives = 103/306 (33%), Gaps = 58/306 (18%) Query: 6 TLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHF 65 + GH T + P+ +ILS D TI +W D R +GH+ Sbjct: 153 KVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHD----YECLRDFQGHNKP 208 Query: 66 VSDVVISSDGQFALSGSWDGTLRLWDLTTGTT---------------------------- 97 + + + D Q LS S+D ++++WD TG Sbjct: 209 IKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLS 268 Query: 98 -----------------TRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKY 140 + + H +L++ + D + +S S DKT+++W Sbjct: 269 NSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPI 328 Query: 141 TVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLAN---CKLKTNHIGHT--GYL 195 ++ + + P S + D + ++L K GH+ GY Sbjct: 329 KQISDTAQHSMPFLNVHP--SQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYG 386 Query: 196 NTVTVSPDGSLCASGGKDGQAMLWDLNEGKHL--YTLDGGDIINALCFSPNRYWLCAATG 253 ++ S DG SG + WD N + L + G I + + P +G Sbjct: 387 ISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQETSKVICSG 446 Query: 254 PSIKIW 259 + KI+ Sbjct: 447 AAGKIY 452 Score = 48.9 bits (115), Expect = 2e-06, Method: Composition-based stats. Identities = 17/88 (19%), Positives = 29/88 (32%), Gaps = 12/88 (13%) Query: 232 GGDIINALCFSPN--RYWLCAATGPSIKIWD-LEGKIIVDELKQEVISTSSKAEPPQCTS 288 + AL F P L +IKIWD + + + + Sbjct: 161 HPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQ---------GHNKPIKA 211 Query: 289 LAWSADGQTLFAGYTDNLVRVWQVTIGT 316 L ++ D Q+ + D V++W G Sbjct: 212 LRFTEDCQSFLSSSFDRSVKIWDTETGK 239 >3JRP-A nrPDB Length = 379 Score = 151 bits (380), Expect = 5e-37, Method: Composition-based stats. Identities = 58/247 (23%), Positives = 95/247 (38%), Gaps = 30/247 (12%) Query: 3 EQMTLRGTLKGHNGWVTQIAT-TPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRG 61 E L TL GH G V ++ P+F ++ S S D +++WK +E Sbjct: 43 ETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWK---EENGRWSQIAVHAV 99 Query: 62 HSHFVSDVVISSD--GQFALSGSWDGTLRLWDLTTGTTTRRFV--GHTKDVLSVAFSS-- 115 HS V+ V + G L S DG + + + TT + H V S +++ Sbjct: 100 HSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPAT 159 Query: 116 -----------DNRQIVSGSRDKTIKLWNTLGVCKYTV---QDESHSEWVSCVRFSPNS- 160 ++R+ V+G D +K+W + V E HS+WV V +SP Sbjct: 160 IEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVL 219 Query: 161 SNPIIVSCGWDKLVKVW--NLANCKLKTNHIGHTGY---LNTVTVSPDGSLCASGGKDGQ 215 + S D+ +W + K + + L + S G++ A G D + Sbjct: 220 LRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNK 279 Query: 216 AMLWDLN 222 LW N Sbjct: 280 VTLWKEN 286 Score = 131 bits (329), Expect = 4e-31, Method: Composition-based stats. Identities = 51/280 (18%), Positives = 96/280 (34%), Gaps = 33/280 (11%) Query: 61 GHSHFVSDVVISSDGQFALSGSWDGTLRLWDL--TTGTTTRRFVGHTKDVLSVAFS--SD 116 H+ + D V+ G+ + S D T++++++ T GH V V ++ Sbjct: 9 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKF 68 Query: 117 NRQIVSGSRDKTIKLWNTL-GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVK 175 + S S D + +W G HS V+ V+++P+ P+++ D V Sbjct: 69 GTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVS 128 Query: 176 VWNLANC--KLKTNHIGHTGYLNTVTVSP-------------DGSLCASGGKDGQAMLWD 220 V H +N+ + +P + +GG D +W Sbjct: 129 VVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWK 188 Query: 221 LNEGKHLYTLD-----GGDIINALCFSPN----RYWLCAATGPSIKIWDLEGKIIVDELK 271 N Y L+ D + + +SP Y + + IW + ++ Sbjct: 189 YNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDN----EQGP 244 Query: 272 QEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQ 311 + + P +WS G L DN V +W+ Sbjct: 245 WKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 284 Score = 117 bits (293), Expect = 6e-27, Method: Composition-based stats. Identities = 58/298 (19%), Positives = 106/298 (35%), Gaps = 36/298 (12%) Query: 27 FPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSD--GQFALSGSWD 84 + + + S DKTI ++++ E L GH V V + G S S+D Sbjct: 22 YGKRLATCSSDKTIKIFEV---EGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYD 78 Query: 85 GTLRLWDLTTGTT--TRRFVGHTKDVLSVAFSS--DNRQIVSGSRDKTIKLWNTLGVCKY 140 G + +W G H+ V SV ++ ++ S D + + Sbjct: 79 GKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTT 138 Query: 141 T-VQDESHSEWVSCVRFSP-----------NSSNPIIVSCGWDKLVKVW----NLANCKL 184 + + ++H+ V+ ++P + V+ G D LVK+W + L Sbjct: 139 SPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVL 198 Query: 185 KTNHIGHTGYLNTVTVSPD---GSLCASGGKDGQAMLW--DLNEGKHLYTLDGGDIINAL 239 ++ GH+ ++ V SP S AS +D ++W D +G TL + + Sbjct: 199 ESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDV 258 Query: 240 ----CFSPNRYWLC-AATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWS 292 +S + L + + +W E E EV + TS + Sbjct: 259 LWRASWSLSGNVLALSGGDNKVTLWK-ENLEGKWEPAGEVHQGGGGSGGGGATSKEFD 315 Score = 75.5 bits (184), Expect = 3e-14, Method: Composition-based stats. Identities = 31/158 (19%), Positives = 51/158 (32%), Gaps = 21/158 (13%) Query: 11 LKGHNGWVTQIATTP------------QFPDMILSASRDKTIIMWKLTRDETNYGIPQRA 58 + H V + P + ++ D + +WK D Y + + Sbjct: 143 IDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTY-VLEST 201 Query: 59 LRGHSHFVSDVVISSD---GQFALSGSWDGTLRLW--DLTTGTTTRRFVGHTK---DVLS 110 L GHS +V DV S + S S D T +W D G + + K + Sbjct: 202 LEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWR 261 Query: 111 VAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHS 148 ++S + D + LW K+ E H Sbjct: 262 ASWSLSGNVLALSGGDNKVTLWKENLEGKWEPAGEVHQ 299 Score = 46.6 bits (109), Expect = 1e-05, Method: Composition-based stats. Identities = 19/136 (13%), Positives = 39/136 (28%), Gaps = 15/136 (11%) Query: 182 CKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDL--NEGKHLYTLDGGD-IINA 238 + H ++ + G A+ D ++++ K + TL G + + Sbjct: 1 GSMVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWR 60 Query: 239 LCF-SPN--RYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSAD- 294 + + P + + IW E + S+ W+ Sbjct: 61 VDWAHPKFGTILASCSYDGKVLIWKEENG-------RWSQIAVHAVHSASVNSVQWAPHE 113 Query: 295 -GQTLFAGYTDNLVRV 309 G L +D V V Sbjct: 114 YGPLLLVASSDGKVSV 129 Score = 41.6 bits (96), Expect = 4e-04, Method: Composition-based stats. Identities = 12/74 (16%), Positives = 27/74 (36%), Gaps = 9/74 (12%) Query: 245 RYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWS--ADGQTLFAGY 302 + ++ +IKI+++EG + + + + W+ G L + Sbjct: 24 KRLATCSSDKTIKIFEVEG-------ETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCS 76 Query: 303 TDNLVRVWQVTIGT 316 D V +W+ G Sbjct: 77 YDGKVLIWKEENGR 90 Score = 30.8 bits (68), Expect = 0.79, Method: Composition-based stats. Identities = 5/37 (13%), Positives = 13/37 (35%) Query: 277 TSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVT 313 + A G+ L +D +++++V Sbjct: 5 VIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVE 41 >3JB9-L nrPDB Length = 340 Score = 149 bits (375), Expect = 2e-36, Method: Composition-based stats. Identities = 58/309 (18%), Positives = 117/309 (37%), Gaps = 32/309 (10%) Query: 13 GHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVIS 72 GH V P S D+ I++W + D NYG+ L G ++D+ S Sbjct: 48 GHTAEVLVARFDP-SGSYFASGGMDRQILLWNVFGDVKNYGV----LNGCKGAITDLQWS 102 Query: 73 SDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSG-SRDKTIKL 131 D + S D L WD +G R+ GH V ++ ++++ S D T+K+ Sbjct: 103 RDSRVVYCSSSDTHLMSWDAVSGQKIRKHKGHAGVVNALDVLKVGSELLTSVSDDCTMKV 162 Query: 132 WNTLGV-CKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIG 190 W++ C T+++ ++ V + + I G D +K+W+L N G Sbjct: 163 WDSRSKDCIKTIEE---KYPLTAVAIAQQGTQVFI--GGIDGAIKIWDLRNNHCSHVLKG 217 Query: 191 HTGYLNTVTVSPDGSLCASGGKDGQAMLWDL----NEGKHLYTLDGG-----DIINALCF 241 H + ++ +S DGS S D ++D+ + + L +G + + + Sbjct: 218 HKDIITSLAISKDGSSLLSNSMDNTVRIFDVKPFASAQRQLQIFEGAIHGQEHNLLGVAW 277 Query: 242 SPNRYWL-CAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFA 300 S N ++ ++ ++ +W G + + + + + Sbjct: 278 SRNSRFVGAGSSDKNVYVWSATGD----------LRYVLPGHEGSVNHVDFHPHQDIILS 327 Query: 301 GYTDNLVRV 309 +D + + Sbjct: 328 CSSDRTIFL 336 Score = 146 bits (369), Expect = 9e-36, Method: Composition-based stats. Identities = 55/221 (24%), Positives = 85/221 (38%), Gaps = 13/221 (5%) Query: 95 GTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCV 154 + GHT +VL F SG D+ I LWN G K ++ + Sbjct: 40 NVPNLQMFGHTAEVLVARFDPSGSYFASGGMDRQILLWNVFGDVKNYGVLNGCKGAITDL 99 Query: 155 RFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGS-LCASGGKD 213 ++S +S ++ D + W+ + + H GH G +N + V GS L S D Sbjct: 100 QWSRDSR--VVYCSSSDTHLMSWDAVSGQKIRKHKGHAGVVNALDVLKVGSELLTSVSDD 157 Query: 214 GQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWL-CAATGPSIKIWDLEGKIIVDELKQ 272 +WD + T++ + A+ + + +IKIWDL LK Sbjct: 158 CTMKVWDSRSKDCIKTIEEKYPLTAVAIAQQGTQVFIGGIDGAIKIWDLRNNHCSHVLK- 216 Query: 273 EVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVT 313 TSLA S DG +L + DN VR++ V Sbjct: 217 --------GHKDIITSLAISKDGSSLLSNSMDNTVRIFDVK 249 Score = 144 bits (363), Expect = 4e-35, Method: Composition-based stats. Identities = 57/277 (20%), Positives = 111/277 (40%), Gaps = 7/277 (2%) Query: 44 KLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDL-TTGTTTRRFV 102 + + ++ +P + GH+ V G + SG D + LW++ Sbjct: 31 SVLQRTSDLNVPNLQMFGHTAEVLVARFDPSGSYFASGGMDRQILLWNVFGDVKNYGVLN 90 Query: 103 GHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSN 162 G + + +S D+R + S D + W+ + + + + H+ V+ + S Sbjct: 91 GCKGAITDLQWSRDSRVVYCSSSDTHLMSWDAVS-GQKIRKHKGHAGVVNALDVLKVGSE 149 Query: 163 PIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLN 222 ++ S D +KVW+ + I L V ++ G+ GG DG +WDL Sbjct: 150 -LLTSVSDDCTMKVWDSRSKDCIKT-IEEKYPLTAVAIAQQGTQVFIGGIDGAIKIWDLR 207 Query: 223 EGKHLYTLDGG-DIINALCFSPNR-YWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSK 280 + L G DII +L S + L + +++I+D++ + ++ + Sbjct: 208 NNHCSHVLKGHKDIITSLAISKDGSSLLSNSMDNTVRIFDVKPFASAQR-QLQIFEGAIH 266 Query: 281 AEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGTR 317 + +AWS + + + AG +D V VW T R Sbjct: 267 GQEHNLLGVAWSRNSRFVGAGSSDKNVYVWSATGDLR 303 Score = 140 bits (352), Expect = 9e-34, Method: Composition-based stats. Identities = 48/216 (22%), Positives = 89/216 (41%), Gaps = 12/216 (5%) Query: 12 KGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVI 71 KGH G V + +++ S S D T+ +W + I ++ + ++ V I Sbjct: 132 KGHAGVVNALDVLKVGSELLTSVSDDCTMKVWDSRSKDCIKTIEEK------YPLTAVAI 185 Query: 72 SSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKL 131 + G G DG +++WDL + GH + S+A S D ++S S D T+++ Sbjct: 186 AQQGTQVFIGGIDGAIKIWDLRNNHCSHVLKGHKDIITSLAISKDGSSLLSNSMDNTVRI 245 Query: 132 WNTL-----GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKT 186 ++ + H + + + + + ++ + + DK V VW+ L+ Sbjct: 246 FDVKPFASAQRQLQIFEGAIHGQEHNLLGVAWSRNSRFVGAGSSDKNVYVWSA-TGDLRY 304 Query: 187 NHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLN 222 GH G +N V P + S D L +LN Sbjct: 305 VLPGHEGSVNHVDFHPHQDIILSCSSDRTIFLGELN 340 Score = 83.6 bits (205), Expect = 9e-17, Method: Composition-based stats. Identities = 36/125 (28%), Positives = 55/125 (44%), Gaps = 5/125 (4%) Query: 10 TLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKL---TRDETNYGIPQRALRGHSHFV 66 LKGH +T +A + +LS S D T+ ++ + + I + A+ G H + Sbjct: 214 VLKGHKDIITSLAISKDGSS-LLSNSMDNTVRIFDVKPFASAQRQLQIFEGAIHGQEHNL 272 Query: 67 SDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRD 126 V S + +F +GS D + +W TG GH V V F I+S S D Sbjct: 273 LGVAWSRNSRFVGAGSSDKNVYVWSA-TGDLRYVLPGHEGSVNHVDFHPHQDIILSCSSD 331 Query: 127 KTIKL 131 +TI L Sbjct: 332 RTIFL 336 Score = 42.4 bits (98), Expect = 3e-04, Method: Composition-based stats. Identities = 16/37 (43%), Positives = 20/37 (54%), Gaps = 1/37 (2%) Query: 6 TLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIM 42 LR L GH G V + P D+ILS S D+TI + Sbjct: 301 DLRYVLPGHEGSVNHVDFHPHQ-DIILSCSSDRTIFL 336 >4BZK-B nrPDB Length = 297 Score = 147 bits (370), Expect = 8e-36, Method: Composition-based stats. Identities = 58/247 (23%), Positives = 95/247 (38%), Gaps = 30/247 (12%) Query: 3 EQMTLRGTLKGHNGWVTQIAT-TPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRG 61 E L TL GH G V ++ P+F ++ S S D +++WK +E Sbjct: 41 ETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWK---EENGRWSQIAVHAV 97 Query: 62 HSHFVSDVVISSD--GQFALSGSWDGTLRLWDLTTGTTTRRFV--GHTKDVLSVAFSS-- 115 HS V+ V + G L S DG + + + TT + H V S +++ Sbjct: 98 HSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPAT 157 Query: 116 -----------DNRQIVSGSRDKTIKLWNTLGVCKYTV---QDESHSEWVSCVRFSPNS- 160 ++R+ V+G D +K+W + V E HS+WV V +SP Sbjct: 158 IEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVL 217 Query: 161 SNPIIVSCGWDKLVKVW--NLANCKLKTNHIGHTGY---LNTVTVSPDGSLCASGGKDGQ 215 + S D+ +W + K + + L + S G++ A G D + Sbjct: 218 LRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNK 277 Query: 216 AMLWDLN 222 LW N Sbjct: 278 VTLWKEN 284 Score = 127 bits (320), Expect = 5e-30, Method: Composition-based stats. Identities = 51/280 (18%), Positives = 96/280 (34%), Gaps = 33/280 (11%) Query: 61 GHSHFVSDVVISSDGQFALSGSWDGTLRLWDL--TTGTTTRRFVGHTKDVLSVAFS--SD 116 H+ + D V+ G+ + S D T++++++ T GH V V ++ Sbjct: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKF 66 Query: 117 NRQIVSGSRDKTIKLWNTL-GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVK 175 + S S D + +W G HS V+ V+++P+ P+++ D V Sbjct: 67 GTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVS 126 Query: 176 VWNLANC--KLKTNHIGHTGYLNTVTVSP-------------DGSLCASGGKDGQAMLWD 220 V H +N+ + +P + +GG D +W Sbjct: 127 VVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWK 186 Query: 221 LNEGKHLYTLD-----GGDIINALCFSPN----RYWLCAATGPSIKIWDLEGKIIVDELK 271 N Y L+ D + + +SP Y + + IW + ++ Sbjct: 187 YNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDN----EQGP 242 Query: 272 QEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQ 311 + + P +WS G L DN V +W+ Sbjct: 243 WKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 282 Score = 114 bits (284), Expect = 8e-26, Method: Composition-based stats. Identities = 50/265 (18%), Positives = 95/265 (35%), Gaps = 35/265 (13%) Query: 27 FPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSD--GQFALSGSWD 84 + + + S DKTI ++++ E L GH V V + G S S+D Sbjct: 20 YGKRLATCSSDKTIKIFEV---EGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYD 76 Query: 85 GTLRLWDLTTGTT--TRRFVGHTKDVLSVAFSS--DNRQIVSGSRDKTIKLWNTLGVCKY 140 G + +W G H+ V SV ++ ++ S D + + Sbjct: 77 GKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTT 136 Query: 141 T-VQDESHSEWVSCVRFSP-----------NSSNPIIVSCGWDKLVKVW----NLANCKL 184 + + ++H+ V+ ++P + V+ G D LVK+W + L Sbjct: 137 SPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVL 196 Query: 185 KTNHIGHTGYLNTVTVSPD---GSLCASGGKDGQAMLW--DLNEGKHLYTLDGGDIINAL 239 ++ GH+ ++ V SP S AS +D ++W D +G TL + + Sbjct: 197 ESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDV 256 Query: 240 CFS-----PNRYWLCAATGPSIKIW 259 + + + +W Sbjct: 257 LWRASWSLSGNVLALSGGDNKVTLW 281 Score = 73.6 bits (179), Expect = 1e-13, Method: Composition-based stats. Identities = 31/158 (19%), Positives = 51/158 (32%), Gaps = 21/158 (13%) Query: 11 LKGHNGWVTQIATTP------------QFPDMILSASRDKTIIMWKLTRDETNYGIPQRA 58 + H V + P + ++ D + +WK D Y + + Sbjct: 141 IDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTY-VLEST 199 Query: 59 LRGHSHFVSDVVISSD---GQFALSGSWDGTLRLW--DLTTGTTTRRFVGHTK---DVLS 110 L GHS +V DV S + S S D T +W D G + + K + Sbjct: 200 LEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWR 259 Query: 111 VAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHS 148 ++S + D + LW K+ E H Sbjct: 260 ASWSLSGNVLALSGGDNKVTLWKENLEGKWEPAGEVHQ 297 Score = 40.8 bits (94), Expect = 8e-04, Method: Composition-based stats. Identities = 12/74 (16%), Positives = 27/74 (36%), Gaps = 9/74 (12%) Query: 245 RYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWS--ADGQTLFAGY 302 + ++ +IKI+++EG + + + + W+ G L + Sbjct: 22 KRLATCSSDKTIKIFEVEG-------ETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCS 74 Query: 303 TDNLVRVWQVTIGT 316 D V +W+ G Sbjct: 75 YDGKVLIWKEENGR 88 Score = 30.0 bits (66), Expect = 1.2, Method: Composition-based stats. Identities = 5/37 (13%), Positives = 13/37 (35%) Query: 277 TSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVT 313 + A G+ L +D +++++V Sbjct: 3 VIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVE 39 >4XYI-A nrPDB Length = 430 Score = 145 bits (365), Expect = 3e-35, Method: Composition-based stats. Identities = 50/234 (21%), Positives = 99/234 (42%), Gaps = 26/234 (11%) Query: 11 LKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKL-----TRDETNYGIPQRALRGHSHF 65 L+ H + + + + D +I +W + + +++ P H+ Sbjct: 178 LRHHTSEGFGLGWNFIQEGTLATGTEDTSICVWDIKGKSLSLEKSIDVAPVSVYHRHTAV 237 Query: 66 VSDVVISSDGQFALSG-SWDGTLRLWDLT---TGTTTRRFVGHTKDVLSVAFSSDNRQIV 121 V+D+ + L+ S D TL++ D + + ++ H + V VAF+ N ++ Sbjct: 238 VNDLQFHLQHEALLTSVSDDCTLQIHDTRLPSSSSASQCVKAHEQPVNGVAFNPFNDYLL 297 Query: 122 -SGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLA 180 + S D T+ LW+ + + E H + V V++SP+ PI+V+ D+ V VW+L+ Sbjct: 298 ATASADHTVALWDLRRLNQRLHTLEGHEDEVYNVQWSPH-DEPILVTSSTDRRVCVWDLS 356 Query: 181 NC--------------KLKTNHIGHTGYLNTVTVSPDGSL-CASGGKDGQAMLW 219 +L H GHT ++ ++ +P+ AS D +W Sbjct: 357 KIGEEQTVEDSEDGAPELMFMHGGHTNRVSDLSWNPNNKWVLASLADDNILQIW 410 Score = 82.4 bits (202), Expect = 3e-16, Method: Composition-based stats. Identities = 33/237 (13%), Positives = 72/237 (30%), Gaps = 35/237 (14%) Query: 104 HTKDVLSVAFSSDN-RQIVSGSRDKTIKLWNTLGVCKYTVQDESHS-------EWVSCVR 155 H DV F N I + + +++ + + H + Sbjct: 130 HEGDVNKARFMPQNPDIIATLGLNGNGYIFDLNLYREQPIVQTGHQACLRHHTSEGFGLG 189 Query: 156 FSPNSSNPIIVSCGWDKLVKVWNLA----------NCKLKTNHIGHTGYLNTVTVSPDGS 205 ++ + + D + VW++ + + + HT +N + Sbjct: 190 WNFIQEG-TLATGTEDTSICVWDIKGKSLSLEKSIDVAPVSVYHRHTAVVNDLQFHLQHE 248 Query: 206 -LCASGGKDGQAMLWDLN---EGKHLYTLDGGD-IINALCFSP--NRYWLCAATGPSIKI 258 L S D + D + + +N + F+P + A+ ++ + Sbjct: 249 ALLTSVSDDCTLQIHDTRLPSSSSASQCVKAHEQPVNGVAFNPFNDYLLATASADHTVAL 308 Query: 259 WDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSA-DGQTLFAGYTDNLVRVWQVTI 314 WDL + + + + ++ WS D L TD V VW ++ Sbjct: 309 WDLR--------RLNQRLHTLEGHEDEVYNVQWSPHDEPILVTSSTDRRVCVWDLSK 357 Score = 69.3 bits (168), Expect = 2e-12, Method: Composition-based stats. Identities = 21/92 (22%), Positives = 48/92 (52%), Gaps = 10/92 (10%) Query: 10 TLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTR-------DETNYGIPQRALR-- 60 TL+GH V + +P +++++S D+ + +W L++ +++ G P+ Sbjct: 320 TLEGHEDEVYNVQWSPHDEPILVTSSTDRRVCVWDLSKIGEEQTVEDSEDGAPELMFMHG 379 Query: 61 GHSHFVSDVVISSDGQF-ALSGSWDGTLRLWD 91 GH++ VSD+ + + ++ S + D L++W Sbjct: 380 GHTNRVSDLSWNPNNKWVLASLADDNILQIWS 411 Score = 38.5 bits (88), Expect = 0.003, Method: Composition-based stats. Identities = 7/35 (20%), Positives = 17/35 (48%) Query: 13 GHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTR 47 GH V+ ++ P ++ S + D + +W ++ Sbjct: 380 GHTNRVSDLSWNPNNKWVLASLADDNILQIWSPSK 414 >3BG0-A nrPDB Length = 316 Score = 136 bits (343), Expect = 1e-32, Method: Composition-based stats. Identities = 61/249 (24%), Positives = 93/249 (37%), Gaps = 34/249 (13%) Query: 5 MTLRGTLKGHNGWVTQIAT-TPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHS 63 L L+GH G V Q+A P + +++ S S D+ +I+W R+E GH Sbjct: 47 QILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIW---REENGTWEKSHEHAGHD 103 Query: 64 HFVSDVVISSD--GQFALSGSWDGTLRL--------WDLTTGTTTRRF------------ 101 V+ V + G GS DG + L W++ Sbjct: 104 SSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVV 163 Query: 102 VGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTL--GVCKYTVQDESHSEWVSCVRFSPN 159 G D S + ++ SG D IKLW G K + E+HS+WV V ++P+ Sbjct: 164 PGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPS 223 Query: 160 SSNP--IIVSCGWDKLVKVWNL----ANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKD 213 P I SC D V +W +N + V+ S ++ A G D Sbjct: 224 IGLPTSTIASCSQDGRVFIWTCDDASSNTWSPKLLHKFNDVVWHVSWSITANILAVSGGD 283 Query: 214 GQAMLWDLN 222 + LW + Sbjct: 284 NKVTLWKES 292 Score = 119 bits (297), Expect = 2e-27, Method: Composition-based stats. Identities = 52/286 (18%), Positives = 95/286 (33%), Gaps = 39/286 (13%) Query: 62 HSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGT--TTRRFVGHTKDVLSVAFS--SDN 117 H + D + G + S D +++++D+ G GH V VA++ Sbjct: 12 HEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYG 71 Query: 118 RQIVSGSRDKTIKLW-NTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKV 176 + S S D+ + +W G + + + H V+ V ++P+ I+ D + + Sbjct: 72 NILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISL 131 Query: 177 WNL---ANCKLKTNHIGHTGYLNTVTVSP---DGSL--------------CASGGKDGQA 216 ++K + HT N V+ +P GSL ASGG D Sbjct: 132 LTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLI 191 Query: 217 MLWDLNE----GKHLYTLDGGDIINALCFSPN-----RYWLCAATGPSIKIWDLEGKIIV 267 LW E + D + + ++P+ + + IW Sbjct: 192 KLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIW-----TCD 246 Query: 268 DELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVT 313 D ++WS L DN V +W+ + Sbjct: 247 DASSNTWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKES 292 Score = 107 bits (268), Expect = 5e-24, Method: Composition-based stats. Identities = 54/269 (20%), Positives = 98/269 (36%), Gaps = 39/269 (14%) Query: 27 FPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSD--GQFALSGSWD 84 + + + S D+++ ++ + I LRGH V V + G S S+D Sbjct: 24 YGTRLATCSSDRSVKIFDVRNGGQ---ILIADLRGHEGPVWQVAWAHPMYGNILASCSYD 80 Query: 85 GTLRLWDLTTGTTTRRFV--GHTKDVLSVAFSS--DNRQIVSGSRDKTIKLWNTLGVCKY 140 + +W GT + GH V SV ++ + GS D I L G ++ Sbjct: 81 RKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQW 140 Query: 141 TVQ--DESHSEWVSCVRF-----------SPNSSNP----IIVSCGWDKLVKVWNLA--- 180 V+ + +H+ + V + P+ P S G D L+K+W Sbjct: 141 EVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDG 200 Query: 181 NCKLKTNHIGHTGYLNTVTVSPD----GSLCASGGKDGQAMLW-----DLNEGKHLYTLD 231 K + H+ ++ V +P S AS +DG+ +W N Sbjct: 201 QWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASSNTWSPKLLHK 260 Query: 232 GGDIINALCFSPNRYWLCAATGPS-IKIW 259 D++ + +S L + G + + +W Sbjct: 261 FNDVVWHVSWSITANILAVSGGDNKVTLW 289 Score = 89.0 bits (219), Expect = 3e-18, Method: Composition-based stats. Identities = 43/248 (17%), Positives = 87/248 (35%), Gaps = 45/248 (18%) Query: 104 HTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTV-QDESHSEWVSCVRFSPNSSN 162 H + ++ + S D+++K+++ + + H V V ++ Sbjct: 12 HEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYG 71 Query: 163 PIIVSCGWDKLVKVWNLANCKLKTNHI--GHTGYLNTVTVSPD--GSLCASGGKDGQAML 218 I+ SC +D+ V +W N + +H GH +N+V +P G + A G DG L Sbjct: 72 NILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISL 131 Query: 219 --------WDLNEGKHLYTLDGGDIINALCFSPN------------------RYWLCAAT 252 W++ + + +T+ NA+ ++P + + Sbjct: 132 LTYTGEGQWEVKKINNAHTI----GCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGC 187 Query: 253 GPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSAD----GQTLFAGYTDNLVR 308 IK+W E E + +A +AW+ T+ + D V Sbjct: 188 DNLIKLWKEEEDGQWKEEQ------KLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVF 241 Query: 309 VWQVTIGT 316 +W + Sbjct: 242 IWTCDDAS 249 Score = 58.2 bits (139), Expect = 5e-09, Method: Composition-based stats. Identities = 21/90 (23%), Positives = 31/90 (34%), Gaps = 4/90 (4%) Query: 4 QMTLRGTLKGHNGWVTQIATTPQFP---DMILSASRDKTIIMWKLTRDETNYGIPQRALR 60 Q L+ H+ WV +A P I S S+D + +W +N P+ L Sbjct: 201 QWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASSNTWSPKL-LH 259 Query: 61 GHSHFVSDVVISSDGQFALSGSWDGTLRLW 90 + V V S D + LW Sbjct: 260 KFNDVVWHVSWSITANILAVSGGDNKVTLW 289 Score = 32.7 bits (73), Expect = 0.23, Method: Composition-based stats. Identities = 9/44 (20%), Positives = 16/44 (36%) Query: 274 VISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGTR 317 VI+T + G L +D V+++ V G + Sbjct: 4 VINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQ 47 >5WYJ-BE nrPDB Length = 939 Score = 136 bits (342), Expect = 1e-32, Method: Composition-based stats. Identities = 47/234 (20%), Positives = 91/234 (38%), Gaps = 10/234 (4%) Query: 29 DMILSASRD-KTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTL 87 + I++A +D K W + G FV V +S G F GS +G++ Sbjct: 428 ENIITAHKDEKFARTWDMRNKRVGRWTFDTTDDG---FVKSVAMSQCGNFGFIGSSNGSI 484 Query: 88 RLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESH 147 ++++ +G +++ H + V ++ NR++VS D + ++ + Sbjct: 485 TIYNMQSGILRKKYKLHKRAVTGISLDGMNRKMVSCGLDGIVGFYDFN--KSTLLGKLKL 542 Query: 148 SEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLC 207 ++ + + +S + D + V + ++ GH+ + SP+G Sbjct: 543 DAPITAMVYHRSSD--LFALALDDLSIVVIDAVTQRVVRQLWGHSNRITAFDFSPEGRWI 600 Query: 208 ASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAA--TGPSIKIW 259 S D WDL G + + ++ + FSPN L TG I IW Sbjct: 601 VSASLDSTIRTWDLPTGGCIDGIIVDNVATNVKFSPNGDLLATTHVTGNGICIW 654 Score = 99.0 bits (245), Expect = 3e-21, Method: Composition-based stats. Identities = 58/338 (17%), Positives = 125/338 (36%), Gaps = 54/338 (15%) Query: 16 GWVTQIATTPQFPDMILSASRDKTII--MWKLTRDETNYGIPQ------RALRGHSHFVS 67 G VTQ P +I+++ D ++ ++ + + + + R+ GHS S Sbjct: 296 GGVTQATFLNGQP-IIVTSGGDNSLKEYVFDPSLSQGSGDVVVQPPRYLRSRGGHSQPPS 354 Query: 68 DVVIS-SDGQFALSGSWDGTLRLW------DLTTGTTTRRFVGHTK-------------- 106 + + S F LS S D + LW D + ++R H K Sbjct: 355 YIAFADSQSHFMLSASKDRS--LWSFSLRKDAQSQEMSQRL--HKKQDGGRVGGSTIKSK 410 Query: 107 --DVLSVAF--SSDNRQ--IVSGSRDKT-IKLWNTLGVCKYTVQDESHSE-WVSCVRFSP 158 +++++A + I++ +D+ + W+ ++ + +V V S Sbjct: 411 FPEIVALAIENARIGEWENIITAHKDEKFARTWDMRNKRVGRWTFDTTDDGFVKSVAMSQ 470 Query: 159 NSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAML 218 + I + + ++N+ + L+ + H + +++ S G DG Sbjct: 471 CGNFGFI--GSSNGSITIYNMQSGILRKKYKLHKRAVTGISLDGMNRKMVSCGLDGIVGF 528 Query: 219 WDLNEGKHLYTLDGGDIINALCFSPNRYWLC-AATGPSIKIWDLEGKIIVDELKQEVIST 277 +D N+ L L I A+ + + A SI + D + +V +L Sbjct: 529 YDFNKSTLLGKLKLDAPITAMVYHRSSDLFALALDDLSIVVIDAVTQRVVRQL------- 581 Query: 278 SSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIG 315 + T+ +S +G+ + + D+ +R W + G Sbjct: 582 --WGHSNRITAFDFSPEGRWIVSASLDSTIRTWDLPTG 617 Score = 58.6 bits (140), Expect = 3e-09, Method: Composition-based stats. Identities = 31/204 (15%), Positives = 72/204 (35%), Gaps = 20/204 (9%) Query: 117 NRQIVSGSRDKTIKLWNTLGVC---------KYTVQDESHSEWVSCVRFSPNSSNPIIVS 167 + + + D +I ++ K TV + E VS + + +V+ Sbjct: 125 GDYLCASTDDNSIFIYKKSDPQDKYPSEFYTKLTVTEIQGGEIVSLQHLATYLNKLTVVT 184 Query: 168 CGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHL 227 V ++N+ KL + T +P + A G G+ +++++ +GK + Sbjct: 185 KSN---VLLFNVRTGKLVFTSNEFPDQITTAEPAPVLDIIALGTVTGEVIMFNMRKGKRI 241 Query: 228 YTLD-GGDIINALCFSPNR--YWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPP 284 T+ I++L F + + + + +DL+ + + LK + Sbjct: 242 RTIKIPQSRISSLSFRTDGSSHLSVGTSSGDLIFYDLDRRSRIHVLKN-----IHRESYG 296 Query: 285 QCTSLAWSADGQTLFAGYTDNLVR 308 T + + DN ++ Sbjct: 297 GVTQATFLNGQPIIVTSGGDNSLK 320 Score = 57.4 bits (137), Expect = 8e-09, Method: Composition-based stats. Identities = 21/88 (23%), Positives = 34/88 (38%), Gaps = 8/88 (9%) Query: 4 QMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHS 63 + L GH+ +T +P+ I+SAS D TI W L GI Sbjct: 574 TQRVVRQLWGHSNRITAFDFSPE-GRWIVSASLDSTIRTWDLPTGGCIDGIIV------D 626 Query: 64 HFVSDVVISSDGQFALSGSWDGT-LRLW 90 + ++V S +G + G + +W Sbjct: 627 NVATNVKFSPNGDLLATTHVTGNGICIW 654 Score = 28.1 bits (61), Expect = 5.5, Method: Composition-based stats. Identities = 15/101 (14%), Positives = 38/101 (37%), Gaps = 12/101 (11%) Query: 214 GQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQE 273 ++D N L+ + + + S + +++ AA + I+ K ++E E Sbjct: 56 KTFQIYDANTLHLLFVSEKETPSSIVALSAHFHYVYAAYENKVGIY----KRGIEEHLLE 111 Query: 274 VISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTI 314 + + ++ G L A DN + +++ + Sbjct: 112 LETDANVEHLCIF--------GDYLCASTDDNSIFIYKKSD 144 >1NR0-A nrPDB Length = 611 Score = 135 bits (340), Expect = 2e-32, Method: Composition-based stats. Identities = 66/312 (21%), Positives = 121/312 (38%), Gaps = 59/312 (18%) Query: 56 QRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTT-----GTTTRRFVGHTKDVLS 110 HSH + S G + SG G +R+WD T TT F G V Sbjct: 52 TEIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSG---PVKD 108 Query: 111 VAFSSDNRQIVSGSRDK----TIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIV 166 +++ S++++I + + + L++T G + ++ ++ V F P+ II Sbjct: 109 ISWDSESKRIAAVGEGRERFGHVFLFDT-GTSNGNLTGQAR--AMNSVDFKPSRPFRII- 164 Query: 167 SCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKH 226 S D V ++ K K+ HT ++++V +PDGSL AS G DG +L++ +G Sbjct: 165 SGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTK 224 Query: 227 LYTLD--------GGDIINALCFSPNRYWLCAAT-GPSIKIWDLEGKIIVDELKQEVIST 277 + + L +SP+ + +A+ +IKIW++ + + Sbjct: 225 TGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIE 284 Query: 278 SSK----------------------------------AEPPQCTSLAWSADGQTLFAGYT 303 + T+L+ SADG+TLF+ Sbjct: 285 DQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADA 344 Query: 304 DNLVRVWQVTIG 315 + + W ++ G Sbjct: 345 EGHINSWDISTG 356 Score = 129 bits (325), Expect = 1e-30, Method: Composition-based stats. Identities = 69/314 (21%), Positives = 110/314 (35%), Gaps = 22/314 (7%) Query: 1 MTEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALR 60 + + T G L G + + P P I+S S D T+ ++ E + Sbjct: 133 LFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIF-----EGPPFKFKSTFG 187 Query: 61 GHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFV-------GHTKDVLSVAF 113 H+ FV V + DG S DGT+ L++ GT T F H+ V + + Sbjct: 188 EHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTW 247 Query: 114 SSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKL 173 S D +I S S DKTIK+WN + + + + +VS + Sbjct: 248 SPDGTKIASASADKTIKIWNVATLKVEKTIPVGTR--IEDQQLGIIWTKQALVSISANGF 305 Query: 174 VKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLD-- 231 + N + GH + ++ S DG S +G WD++ G Sbjct: 306 INFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDV 365 Query: 232 GGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAW 291 +I + + + +K+ G VD K SS+ LA Sbjct: 366 HATMITGIKTTSKGDLFTVSWDDHLKV-VPAGGSGVDSSKAVANKLSSQP-----LGLAV 419 Query: 292 SADGQTLFAGYTDN 305 SADG A + Sbjct: 420 SADGDIAVAACYKH 433 Score = 125 bits (313), Expect = 3e-29, Method: Composition-based stats. Identities = 66/400 (16%), Positives = 125/400 (31%), Gaps = 102/400 (25%) Query: 5 MTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALR--GH 62 + T H +V + P + S D TI+++ +L+ H Sbjct: 180 FKFKSTFGEHTKFVHSVRYNPD-GSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAH 238 Query: 63 SHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRF--------------------- 101 S V + S DG S S D T+++W++ T + Sbjct: 239 SGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALV 298 Query: 102 ----------------------VGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCK 139 GH K + +++ S+D + + S + I W+ Sbjct: 299 SISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGIS 358 Query: 140 YTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVW--------------NLANCKLK 185 V + H+ ++ ++ +S + + WD +KV N + + Sbjct: 359 NRVFPDVHATMITGIK---TTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPL 415 Query: 186 TNHIGHTGYL--------------------------NTVTVSPDGSLCASGGKDGQAMLW 219 + G + + V +S D A GG+D + ++ Sbjct: 416 GLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVY 475 Query: 220 DLN--EGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVIST 277 L+ + T+ I ++ FS N +L A D K+I + Sbjct: 476 KLSGASVSEVKTIVHPAEITSVAFSNNGAFLVAT--------DQSRKVIPYSVANNFELA 527 Query: 278 SSKA---EPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTI 314 + + + ++WS D L G DN V VW + Sbjct: 528 HTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNK 567 Score = 97.1 bits (240), Expect = 9e-21, Method: Composition-based stats. Identities = 63/384 (16%), Positives = 123/384 (32%), Gaps = 95/384 (24%) Query: 13 GHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRAL------------- 59 H+G V + +P I SAS DKTI +W + + IP Sbjct: 237 AHSGSVFGLTWSPD-GTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQ 295 Query: 60 -------------------------RGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTT 94 GH+ ++ + S+DG+ S +G + WD++T Sbjct: 296 ALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDIST 355 Query: 95 GTTTRRF-VGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNT------------------- 134 G + R F H + + +S + + S D +K+ Sbjct: 356 GISNRVFPDVHATMITGIKTTSKGD-LFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQP 414 Query: 135 ------------LGVCKYTVQDESHSEWV--------SCVRFSPNSSNPIIVSCGWDKLV 174 + C + SH + SCV S + + G D V Sbjct: 415 LGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALS--NDKQFVAVGGQDSKV 472 Query: 175 KVWNLANCKL-KTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLD-- 231 V+ L+ + + I H + +V S +G+ + + + + + + L + Sbjct: 473 HVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSW 532 Query: 232 --GGDIINALCFSPNRYWLCAAT-GPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTS 288 + + +SP+ L + S+ +W++ I S Sbjct: 533 TFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPS------DHPIIIKGAHAMSSVNS 586 Query: 289 LAWSADGQTLFAGYTDNLVRVWQV 312 + W + T+ + D+ ++ W V Sbjct: 587 VIWLNE-TTIVSAGQDSNIKFWNV 609 Score = 87.8 bits (216), Expect = 5e-18, Method: Composition-based stats. Identities = 53/297 (17%), Positives = 108/297 (36%), Gaps = 55/297 (18%) Query: 13 GHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVIS 72 GHN +T ++ + + SA + I W ++ +N P H+ ++ + + Sbjct: 322 GHNKAITALS-SSADGKTLFSADAEGHINSWDISTGISNRVFPDV----HATMITGIKTT 376 Query: 73 SDGQFALSGSWDGTLRLW------------------------------DLTTGTTTR--R 100 S G + SWD L++ D+ + Sbjct: 377 SKGD-LFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIA 435 Query: 101 FVGHTK--------DVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVS 152 H K + VA S+D + + G +D + ++ G V+ H ++ Sbjct: 436 IYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEIT 495 Query: 153 CVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIG---HTGYLNTVTVSPDGSLCAS 209 V FS N + +V+ + V +++AN + HT + V+ SPD A+ Sbjct: 496 SVAFSNNGA--FLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLAT 553 Query: 210 GGKDGQAMLWDLNEGKH----LYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLE 262 G D ++W++N+ + +N++ + + A +IK W++ Sbjct: 554 GSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWNVP 610 Score = 63.2 bits (152), Expect = 1e-10, Method: Composition-based stats. Identities = 31/186 (16%), Positives = 64/186 (34%), Gaps = 24/186 (12%) Query: 141 TVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCK--LKTNHIGHTGYLNTV 198 + SH V+ S S V++W+ LKT +G + + Sbjct: 54 IYTEHSHQTTVAKTS----PSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDI 109 Query: 199 TVSPDGSLCASGGKD----GQAMLWDLNEGKHLYTLDGGD-IINALCFSPNRYW--LCAA 251 + + A+ G+ G L+D G L G +N++ F P+R + + + Sbjct: 110 SWDSESKRIAAVGEGRERFGHVFLFD--TGTSNGNLTGQARAMNSVDFKPSRPFRIISGS 167 Query: 252 TGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQ 311 ++ I+ E ++ S+ ++ DG + D + ++ Sbjct: 168 DDNTVAIF---------EGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYN 218 Query: 312 VTIGTR 317 GT+ Sbjct: 219 GVDGTK 224 >2HES-X nrPDB Length = 330 Score = 134 bits (338), Expect = 4e-32, Method: Composition-based stats. Identities = 58/240 (24%), Positives = 96/240 (40%), Gaps = 23/240 (9%) Query: 2 TEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRG 61 T +M L ++GH V +A + + + SRDK++ +W+ Y L+ Sbjct: 94 TFEMDLLAIIEGHENEVKGVAWS-NDGYYLATCSRDKSVWIWETDESGEEY-ECISVLQE 151 Query: 62 HSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTG--TTTRRFVGHTKDVLSVAFSSDNR- 118 HS V V+ S S+D T+R+W GH V S F Sbjct: 152 HSQDVKHVIWHPSEALLASSSYDDTVRIWKDYDDDWECVAVLNGHEGTVWSSDFDKTEGV 211 Query: 119 -QIVSGSRDKTIKLWNTLGVCK--------YTVQDESHSEWVSCVRFSPNSSNPIIVSCG 169 ++ SGS D T+++W +G + + + H V V + N +I S G Sbjct: 212 FRLCSGSDDSTVRVWKYMGDDEDDQQEWVCEAILPDVHKRQVYNVAWGFNG---LIASVG 268 Query: 170 WDKLVKVWNLANCKLK---TNHIGHTGY-LNTVTVSP-DGS-LCASGGKDGQAMLWDLNE 223 D ++ V+ + + K + H Y +N V +G + A+GG DG W L + Sbjct: 269 ADGVLAVYEEVDGEWKVFAKRALCHGVYEINVVKWLELNGKTILATGGDDGIVNFWSLEK 328 Score = 132 bits (332), Expect = 2e-31, Method: Composition-based stats. Identities = 57/336 (16%), Positives = 108/336 (32%), Gaps = 37/336 (11%) Query: 7 LRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFV 66 L +LK + + + ++ + S D+ I + + D+ I H + Sbjct: 6 LIKSLKLYKEKIWSFDFS---QGILATGSTDRKIKLVSVKYDDFTL-IDVLDETAHKKAI 61 Query: 67 SDVVISSDGQFALSGSWDGTLRLW-------DLTTGTTTRRFVGHTKDVLSVAFSSDNRQ 119 V +GS+D T+ +W GH +V VA+S+D Sbjct: 62 RSVAWRPHTSLLAAGSFDSTVSIWAKEESADRTFEMDLLAIIEGHENEVKGVAWSNDGYY 121 Query: 120 IVSGSRDKTIKLWNTLGVCKY---TVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKV 176 + + SRDK++ +W T + + HS+ V V + P S ++ S +D V++ Sbjct: 122 LATCSRDKSVWIWETDESGEEYECISVLQEHSQDVKHVIWHP--SEALLASSSYDDTVRI 179 Query: 177 WNL--ANCKLKTNHIGHTGYLNTVTVSPDGSLC--ASGGKDGQAMLW--------DLNEG 224 W + + GH G + + + SG D +W D E Sbjct: 180 WKDYDDDWECVAVLNGHEGTVWSSDFDKTEGVFRLCSGSDDSTVRVWKYMGDDEDDQQEW 239 Query: 225 KHLYTLD--GGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAE 282 L + + + N + ++ VD + + Sbjct: 240 VCEAILPDVHKRQVYNVAWGFNGLIASVGADGVLAVY-----EEVDGEWKVFAKRALCHG 294 Query: 283 PPQCTSLAWSADG--QTLFAGYTDNLVRVWQVTIGT 316 + + W L G D +V W + Sbjct: 295 VYEINVVKWLELNGKTILATGGDDGIVNFWSLEKAA 330 >5OQL-L nrPDB Length = 557 Score = 134 bits (337), Expect = 6e-32, Method: Composition-based stats. Identities = 49/242 (20%), Positives = 93/242 (38%), Gaps = 21/242 (8%) Query: 87 LRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTV--QD 144 + ++ + + + D R +V+G +++++ + + Sbjct: 81 VEIFSIRKREPLKTIGRFDSEAHCGEIRPDGRVLVAGEDTGRMQVFDVGQGTRAVILKTW 140 Query: 145 ESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSP-- 202 H + V ++SP ++SC DK V++W+L + GHT Y+ P Sbjct: 141 HIHKQPVWVTKWSPT-ELTTLMSCSDDKTVRLWDLPSNDPTRLFTGHTDYVRCGAFMPGS 199 Query: 203 -DGSLCASGGKDGQAMLWDLNE-GKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWD 260 + +L SG D +WD G + T D I + P+ L AA+G +I + D Sbjct: 200 ANSNLLVSGSYDETVRVWDARAPGGAVMTFKHADPIEDVLPLPSGTTLLAASGNAISVLD 259 Query: 261 LEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRV-----WQVTIG 315 L + + TSL+ ++ G+ + +G D V+V W V G Sbjct: 260 LVAAKPLRLI---------TNHQKTVTSLSLASQGRRVVSGSLDGHVKVFETTSWNVVAG 310 Query: 316 TR 317 + Sbjct: 311 AK 312 Score = 133 bits (335), Expect = 1e-31, Method: Composition-based stats. Identities = 47/257 (18%), Positives = 94/257 (36%), Gaps = 22/257 (8%) Query: 12 KGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVI 71 + H G + ++++ + ++ + + + + H V Sbjct: 101 EAHCGEIR------PDGRVLVAGEDTGRMQVFDVGQGTRAVILKTWHI--HKQPVWVTKW 152 Query: 72 SSDG-QFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSS---DNRQIVSGSRDK 127 S +S S D T+RLWDL + TR F GHT V AF ++ +VSGS D+ Sbjct: 153 SPTELTTLMSCSDDKTVRLWDLPSNDPTRLFTGHTDYVRCGAFMPGSANSNLLVSGSYDE 212 Query: 128 TIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTN 187 T+++W+ + H++ + V P+ + + S + V +L K Sbjct: 213 TVRVWDARAPGGAVMTF-KHADPIEDVLPLPSGTTLLAASG---NAISVLDLVAAKPLRL 268 Query: 188 HIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINAL------CF 241 H + +++++ G SG DG +++ + I +L Sbjct: 269 ITNHQKTVTSLSLASQGRRVVSGSLDGHVKVFETTSWNVVAGAKYPSPILSLSVITAGAS 328 Query: 242 SPNRYWLCAATGPSIKI 258 +R+ + I Sbjct: 329 HDDRHLAVGMQSGVLSI 345 Score = 91.7 bits (226), Expect = 4e-19, Method: Composition-based stats. Identities = 33/133 (24%), Positives = 56/133 (42%), Gaps = 8/133 (6%) Query: 6 TLRGTLKGHNGWVTQIATTPQ--FPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHS 63 GH +V A P ++++S S D+T+ +W G + H+ Sbjct: 178 DPTRLFTGHTDYVRCGAFMPGSANSNLLVSGSYDETVRVWDARA----PGGAVMTFK-HA 232 Query: 64 HFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSG 123 + DV+ G L+ S + + DL R H K V S++ +S R++VSG Sbjct: 233 DPIEDVLPLPSGTTLLAASG-NAISVLDLVAAKPLRLITNHQKTVTSLSLASQGRRVVSG 291 Query: 124 SRDKTIKLWNTLG 136 S D +K++ T Sbjct: 292 SLDGHVKVFETTS 304 >5OQL-X nrPDB Length = 630 Score = 134 bits (336), Expect = 6e-32, Method: Composition-based stats. Identities = 65/357 (18%), Positives = 113/357 (31%), Gaps = 83/357 (23%) Query: 15 NGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQ------------------ 56 +G VT +A P + + ++D + WKL N Sbjct: 170 SGTVTSVAVCPPYAY---TTTKDGYLTKWKLQDLPKNQWPQTTKKKPKKPPAPPKKRPER 226 Query: 57 -------------RALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVG 103 + +GH V S DG+F ++G D L +++ + F Sbjct: 227 ICFAKADARKANDKTYQGHLKAPLVVKASQDGKFVVTGGADKRLVVYNAADLKPIKAFTQ 286 Query: 104 HTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNP 163 H V +AF Q+ S S+D+T+K+W +L Y H + + + Sbjct: 287 HRDAVTGLAFRRGTNQLYSCSKDRTVKVW-SLDELAYVETLFGHQDEI--LDIDALGQER 343 Query: 164 IIVSCGWDKLVKVWNLANCKLKTNHIG-----------------------HTGYLNTVTV 200 + D+ + W + G H G ++ V + Sbjct: 344 CVSVGARDRTARYWKVPEESQLVFRGGGEGGSSNTKKHKLPPGMDPASAAHEGSMDRVAM 403 Query: 201 SPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWD 260 D + +G +G LW + K L+ + P IK+ D Sbjct: 404 I-DDDMFVTGSDNGDLALWSIQRKKPLHVIARAH----------------GLEPPIKLED 446 Query: 261 LEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGTR 317 I D S +P T+L +F+G D +RVW+++ R Sbjct: 447 YSADEIPDP------SIIPAPQPRGITALRTLPYSDLIFSGSWDGCIRVWRLSEDKR 497 Score = 77.0 bits (188), Expect = 1e-14, Method: Composition-based stats. Identities = 47/235 (20%), Positives = 78/235 (33%), Gaps = 58/235 (24%) Query: 5 MTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSH 64 + H VT +A + + + S S+D+T+ +W L DE Y L GH Sbjct: 278 LKPIKAFTQHRDAVTGLAF-RRGTNQLYSCSKDRTVKVWSL--DELAY---VETLFGHQD 331 Query: 65 FVSDVVISSDGQFALSGSWDGTLRLWDL---------------TTGTTTRRF-------- 101 + D+ + G+ D T R W + ++ T + Sbjct: 332 EILDIDALGQERCVSVGARDRTARYWKVPEESQLVFRGGGEGGSSNTKKHKLPPGMDPAS 391 Query: 102 VGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHS------------- 148 H + VA D V+GS + + LW+ V +H Sbjct: 392 AAHEGSMDRVAMIDD-DMFVTGSDNGDLALWSIQRKKPLHVIARAHGLEPPIKLEDYSAD 450 Query: 149 -------------EWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIG 190 ++ +R P S +I S WD ++VW L+ K K +G Sbjct: 451 EIPDPSIIPAPQPRGITALRTLPYSD--LIFSGSWDGCIRVWRLSEDKRKLEAVG 503 >5WLC-LU nrPDB Length = 489 Score = 133 bits (334), Expect = 1e-31, Method: Composition-based stats. Identities = 59/337 (17%), Positives = 114/337 (33%), Gaps = 51/337 (15%) Query: 13 GHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVIS 72 GH V IA + + + S D I W ++ E + + H V+ + ++ Sbjct: 65 GHRDGVYAIAKNYGSLNKLATGSADGVIKYWNMSTREEFV-----SFKAHYGLVTGLCVT 119 Query: 73 S-----------DGQFALSGSWDGTLRLW----DLTTGTT-------------TRRFVGH 104 F LS S D T++LW D + R F G Sbjct: 120 QPRFHDKKPDLKSQNFMLSCSDDKTVKLWSINVDDYSNKNSSDNDSVTNEEGLIRTFDG- 178 Query: 105 TKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPI 164 + +N +G I LW+ + + ++ ++ ++F+ N ++ I Sbjct: 179 ESAFQGIDSHRENSTFATGGA--KIHLWDVNRLKPVSDLSWG-ADNITSLKFNQNETD-I 234 Query: 165 IVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSL-CASGGKDGQAMLWDLNE 223 + S G D + +++L T I T N + +P + + +D A +D+ Sbjct: 235 LASTGSDNSIVLYDLRTNSP-TQKIVQTMRTNAICWNPMEAFNFVTANEDHNAYYYDMRN 293 Query: 224 GKHLYTL--DGGDIINALCFSPNR-YWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSK 280 + D + + FSP + + SI+I+ Sbjct: 294 LSRSLNVFKDHVSAVMDVDFSPTGDEIVTGSYDKSIRIY--------KTNHGHSREIYHT 345 Query: 281 AEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGTR 317 + +S D + + +G D VR+W+ R Sbjct: 346 KRMQHVFQVKYSMDSKYIISGSDDGNVRLWRSKAWER 382 >3ODT-A nrPDB Length = 313 Score = 132 bits (332), Expect = 2e-31, Method: Composition-based stats. Identities = 77/311 (24%), Positives = 127/311 (40%), Gaps = 31/311 (9%) Query: 5 MTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSH 64 L TLKGH+ V + + S SRD T+ +W +D+ G +G Sbjct: 8 YQLSATLKGHDQDVRDVVA--VDDSKVASVSRDGTVRLWS--KDDQWLGTVVYTGQG--- 60 Query: 65 FVSDVVISSDGQFALSGSWDGTLR---LWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIV 121 F++ V S+ + L G D + L+ + +GH +V S++F ++ Sbjct: 61 FLNSVCYDSEKELLLFGGKDTMINGVPLFATSGEDPLYTLIGHQGNVCSLSFQDG--VVI 118 Query: 122 SGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLAN 181 SGS DKT K+W ++H+ V + S N + + DK +K+W N Sbjct: 119 SGSWDKTAKVWK---EGSLVYNLQAHNASVWDAKVVSFSENKFL-TASADKTIKLW--QN 172 Query: 182 CKLKTNHIG-HTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDI-INAL 239 K+ G H + + V DG S DG L D++ G L T +G + + + Sbjct: 173 DKVIKTFSGIHNDVVRHLAVVDDGH-FISCSNDGLIKLVDMHTGDVLRTYEGHESFVYCI 231 Query: 240 CFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLF 299 PN + +++IW E LKQ + + C S +G + Sbjct: 232 KLLPNGDIVSCGEDRTVRIWSKENGS----LKQVITLPAISIWSVDCMS-----NGDIIV 282 Query: 300 AGYTDNLVRVW 310 G +DNLVR++ Sbjct: 283 -GSSDNLVRIF 292 Score = 104 bits (258), Expect = 8e-23, Method: Composition-based stats. Identities = 54/263 (20%), Positives = 94/263 (35%), Gaps = 22/263 (8%) Query: 58 ALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDN 117 L+GH V DVV D + S S DGT+RLW + SV + S+ Sbjct: 13 TLKGHDQDVRDVVAVDDSK-VASVSRDGTVRLWSKDDQWLGTVVYTGQGFLNSVCYDSEK 71 Query: 118 RQIVSGSRDKTIK---LWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLV 174 ++ G +D I L+ T G H V + F + +++S WDK Sbjct: 72 ELLLFGGKDTMINGVPLFATSGE-DPLYTLIGHQGNVCSLSFQ----DGVVISGSWDKTA 126 Query: 175 KVWNLANCKLKTNHIGHTGYLNTVTV-SPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGG 233 KVW L N H + V S + + D LW ++ ++ Sbjct: 127 KVW--KEGSLVYNLQAHNASVWDAKVVSFSENKFLTASADKTIKLWQNDKVIKTFSGIHN 184 Query: 234 DIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSA 293 D++ L + +++ + IK+ D+ ++ + + Sbjct: 185 DVVRHLAVVDDGHFISCSNDGLIKLVDMHTGDVLRTYE---------GHESFVYCIKLLP 235 Query: 294 DGQTLFAGYTDNLVRVWQVTIGT 316 +G + + D VR+W G+ Sbjct: 236 NGD-IVSCGEDRTVRIWSKENGS 257 Score = 94.4 bits (233), Expect = 5e-20, Method: Composition-based stats. Identities = 49/181 (27%), Positives = 78/181 (43%), Gaps = 18/181 (9%) Query: 7 LRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRG-HSHF 65 L L+ HN V + L+AS DKTI +W+ + + G H+ Sbjct: 134 LVYNLQAHNASVWDAKVVSFSENKFLTASADKTIKLWQNDK-------VIKTFSGIHNDV 186 Query: 66 VSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSR 125 V + + DG F S S DG ++L D+ TG R + GH V + + IVS Sbjct: 187 VRHLAVVDDGHFI-SCSNDGLIKLVDMHTGDVLRTYEGHESFVYCIKLLPNGD-IVSCGE 244 Query: 126 DKTIKLW-NTLGVCKYTVQDESHSEW-VSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCK 183 D+T+++W G K + + S W V C+ SN I+ D LV++++ + Sbjct: 245 DRTVRIWSKENGSLKQVITLPAISIWSVDCM------SNGDIIVGSSDNLVRIFSQEKSR 298 Query: 184 L 184 Sbjct: 299 W 299 Score = 60.1 bits (144), Expect = 1e-09, Method: Composition-based stats. Identities = 36/183 (19%), Positives = 68/183 (37%), Gaps = 18/183 (9%) Query: 133 NTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHT 192 + + + + H + V V +S + S D V++W+ + L T Sbjct: 3 DPFTGYQLSATLKGHDQDVRDVVAVDDSK---VASVSRDGTVRLWSKDDQWLGTVVYTGQ 59 Query: 193 GYLNTVTVSPDGSLCASGGKD---GQAMLWDLNEGKHLYTLDGGDI-INALCFSPNRYWL 248 G+LN+V + L GGKD L+ + LYTL G + +L F + + Sbjct: 60 GFLNSVCYDSEKELLLFGGKDTMINGVPLFATSGEDPLYTLIGHQGNVCSLSF-QDGVVI 118 Query: 249 CAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVR 308 + + K+W + +V L+ A +++S D ++ Sbjct: 119 SGSWDKTAKVW--KEGSLVYNLQAH------NASVWDAKVVSFSE--NKFLTASADKTIK 168 Query: 309 VWQ 311 +WQ Sbjct: 169 LWQ 171 >6BX3-A nrPDB Length = 314 Score = 131 bits (329), Expect = 5e-31, Method: Composition-based stats. Identities = 57/264 (21%), Positives = 106/264 (40%), Gaps = 20/264 (7%) Query: 67 SDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRF-VGHTKDVLSVAFSSDNRQIVSGSR 125 + IS DGQF + + ++D+ T ++ H + + +S D + I + S Sbjct: 16 TCAKISPDGQFLAI-TQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASD 74 Query: 126 DKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLK 185 D ++++ + H+ V + + N ++ + D+ +K+W+ N L Sbjct: 75 DFSVEIIHL--SYGLLHTFIGHTAPV--ISLTFNRKGNLLFTSSMDESIKIWDTLNGSLM 130 Query: 186 TNHIGHTGYLNTVTV-SPDGSLCASGGKDGQAMLWDLNEGKHLYTL---------DGGDI 235 H+ + +V V D S+ +SG DG ++D G L TL +G Sbjct: 131 KTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVP 190 Query: 236 INALCFSPN-RYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSAD 294 I+ + FS N RY L + +KIWD G +V + + + L D Sbjct: 191 ISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLN-PED 249 Query: 295 GQT--LFAGYTDNLVRVWQVTIGT 316 G T + +GY + + W + Sbjct: 250 GSTPLVISGYENGDIYCWNSDTKS 273 Score = 104 bits (258), Expect = 8e-23, Method: Composition-based stats. Identities = 50/279 (17%), Positives = 104/279 (37%), Gaps = 27/279 (9%) Query: 1 MTEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALR 60 + + + + H +++ +P I +AS D ++ + L+ Sbjct: 40 INRRTVSQTLVTSHARPFSELCWSPD-GQCIATASDDFSVEIIHLSYG------LLHTFI 92 Query: 61 GHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFS-SDNRQ 119 GH+ V + + G + S D ++++WD G+ + H++ V+SV +D+ Sbjct: 93 GHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSI 152 Query: 120 IVSGSRDKTIKLWNT-LGVCKYTVQDES----HSEWVSCVRFSPNSSNPIIVSCGWDKLV 174 + SGS D I++++ G C T+ + + V + + + ++ D +V Sbjct: 153 LSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVV 212 Query: 175 KVWNLANCKLKTNHIGHTGYLNTVTVSP--------DGS--LCASGGKDGQAMLWDLNEG 224 K+W+ + + S DGS L SG ++G W+ + Sbjct: 213 KIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTK 272 Query: 225 KHLYTLDG---GDIINALCFSPNRYWLCA-ATGPSIKIW 259 L LDG + +C+ A +W Sbjct: 273 SLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGDCCLW 311 >4PSX-B nrPDB Length = 401 Score = 130 bits (328), Expect = 5e-31, Method: Composition-based stats. Identities = 59/282 (20%), Positives = 117/282 (41%), Gaps = 38/282 (13%) Query: 14 HNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISS 73 H +T+ PQ P+++ + + T ++ + Q L+ H + S+ Sbjct: 117 HEEEITRARYMPQDPNIVATINGQGTTFLYSRSEG------LQSTLKFHKDNGYALSFST 170 Query: 74 --DGQFALSGSWDGTLRLWDLTTGTTTRRFVG-----HTKDVLSVAFSSDNRQIV-SGSR 125 G+ LSGS D T+ LW++ +G + V H+ + + + N+ + + S Sbjct: 171 LVKGR-LLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSE 229 Query: 126 DKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLK 185 D +K+ + T+ + + + FS +SSN ++ + G D V +++L N K Sbjct: 230 DSLLKINDVR-ANNTTIDTVKCPQPFNTLAFSHHSSN-LLAAAGMDSYVYLYDLRNMKEP 287 Query: 186 TNHI-GHTGYLNTVTVSP--DGSLCASGGKDGQAMLWDLNE--------------GKHLY 228 +H+ GH +N + S DG + S G D + M+WDL + + + Sbjct: 288 LHHMSGHEDAVNNLEFSTHVDG-VVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIM 346 Query: 229 TLDGG-DIINALCFSPNRYWLCAAT--GPSIKIWDLEGKIIV 267 G +N +P WL A+ +++W + + Sbjct: 347 VHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCSHSLPI 388 Score = 110 bits (275), Expect = 8e-25, Method: Composition-based stats. Identities = 47/239 (19%), Positives = 94/239 (39%), Gaps = 20/239 (8%) Query: 7 LRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRG-HSHF 65 L+ TLK H ++ + +LS S D T+ +W++ + P R HS Sbjct: 152 LQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSG-GDPTKPVRTWNDLHSDI 210 Query: 66 VSDVVISS-DGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSS-DNRQIVSG 123 ++D + + + S D L++ D+ TT V + ++AFS + + + Sbjct: 211 INDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAA 270 Query: 124 SRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANC- 182 D + L++ + + H + V+ + FS + ++VS G D + +W+L Sbjct: 271 GMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDG-VVVSSGSDNRLMMWDLKQIG 329 Query: 183 -------------KLKTNHIGHTGYLNTVTVSPDGSLC-ASGGKDGQAMLWDLNEGKHL 227 +L H GH +N ++P AS ++ +W + + Sbjct: 330 AEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCSHSLPI 388 Score = 62.0 bits (149), Expect = 3e-10, Method: Composition-based stats. Identities = 36/220 (16%), Positives = 78/220 (35%), Gaps = 20/220 (9%) Query: 104 HTKDVLSVAFSS-DNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSN 162 H +++ + D + + + T L++ + T++ H + + FS Sbjct: 117 HEEEITRARYMPQDPNIVATINGQGTTFLYSRSEGLQSTLKF--HKDNGYALSFSTLVKG 174 Query: 163 PIIVSCGWDKLVKVWNLANC----KLKTNHIG-HTGYLNTVTVSP-DGSLCASGGKDGQA 216 ++ S D V +W + + K H+ +N + L + +D Sbjct: 175 RLL-SGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLL 233 Query: 217 MLWDLN-EGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVI 275 + D+ + T+ N L FS + L AA G ++ + + + + L Sbjct: 234 KINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPL----- 288 Query: 276 STSSKAEPPQCTSLAWSA--DGQTLFAGYTDNLVRVWQVT 313 +L +S DG + +G DN + +W + Sbjct: 289 -HHMSGHEDAVNNLEFSTHVDGVVVSSGS-DNRLMMWDLK 326 Score = 35.4 bits (80), Expect = 0.033, Method: Composition-based stats. Identities = 15/90 (16%), Positives = 32/90 (35%), Gaps = 9/90 (10%) Query: 227 LYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQC 286 + + I + P + A +G + + E + ++ K Sbjct: 112 TAKYEHEEEITRARYMPQDPNIVATING-------QGTTFLYS-RSEGLQSTLKFHKDNG 163 Query: 287 TSLAWSA-DGQTLFAGYTDNLVRVWQVTIG 315 +L++S L +G D+ V +W+V G Sbjct: 164 YALSFSTLVKGRLLSGSDDHTVALWEVGSG 193 Score = 33.5 bits (75), Expect = 0.11, Method: Composition-based stats. Identities = 12/46 (26%), Positives = 19/46 (41%) Query: 13 GHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRA 58 GH V PQ P ++ SA + + +WK + G P + Sbjct: 350 GHRSSVNDFDLNPQIPWLVASAEEENILQVWKCSHSLPIVGGPPKV 395 >5WLC-LJ nrPDB Length = 513 Score = 130 bits (327), Expect = 8e-31, Method: Composition-based stats. Identities = 61/322 (18%), Positives = 120/322 (37%), Gaps = 35/322 (10%) Query: 3 EQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGH 62 Q T +K HN VT I+ PQ P S + I TR + Sbjct: 28 RQYTSAQLVKEHNS-VTHISFNPQHPHDFAVTSSTRVQIFSSRTRQV------IKTFSRF 80 Query: 63 SHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVA--FSSDNRQI 120 V SDG+ +G G + ++D T + + V + DN+ + Sbjct: 81 KDVVYSASFRSDGKLLCAGDATGLVSVYDSYNPRTILLSINASTHPTHVTKFHTQDNKIL 140 Query: 121 VSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLA 180 + S D+ +LW+ + ++ +++V + F P + + ++ + +D L+++++ Sbjct: 141 ATASDDRVTRLWDISNAYEPQLELTGATDYVRTLSFIPAAPH-LVATGSYDGLIRLYDTR 199 Query: 181 -NCKLKTNHIGHTGYL-NTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTL-DGGDIIN 237 + + H + N + VSP + S G + +WDL K LY + + Sbjct: 200 SSGSTPIYSLNHDQPVENVIAVSP--TQIVSCGGNN-FKVWDLTSNKKLYERGNFNKAVT 256 Query: 238 ALCF-----SP-NRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAW 291 L + SP + ++ +K++D +D + + S A Sbjct: 257 CLDYVENFDSPMQSALIASSLDGHVKVFD-----PLDNFQVKF----GWKFSGPVLSCAV 307 Query: 292 SAD----GQTLFAGYTDNLVRV 309 S + L AG + L+ + Sbjct: 308 SPSTAQGNRHLVAGLSSGLLAI 329 Score = 120 bits (302), Expect = 5e-28, Method: Composition-based stats. Identities = 47/263 (17%), Positives = 103/263 (39%), Gaps = 23/263 (8%) Query: 59 LRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNR 118 ++ H+ V+ + + + + ++++ T + F V S +F SD + Sbjct: 36 VKEHNS-VTHISFNPQHPHDFAVTSSTRVQIFSSRTRQVIKTFSRFKDVVYSASFRSDGK 94 Query: 119 QIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWN 178 + +G + ++++ + + + +F N I+ + D++ ++W+ Sbjct: 95 LLCAGDATGLVSVYDSYNPRTILLSINASTHPTHVTKFH-TQDNKILATASDDRVTRLWD 153 Query: 179 LAN-CKLKTNHIGHTGYLNTVTVSPDG-SLCASGGKDGQAMLWDLNE--GKHLYTLDGGD 234 ++N + + G T Y+ T++ P L A+G DG L+D +Y+L+ Sbjct: 154 ISNAYEPQLELTGATDYVRTLSFIPAAPHLVATGSYDGLIRLYDTRSSGSTPIYSLNHDQ 213 Query: 235 II-NALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAW-- 291 + N + SP + + + G + K+WDL + E T L + Sbjct: 214 PVENVIAVSPTQ--IVSCGGNNFKVWDLTSNKKLYE---------RGNFNKAVTCLDYVE 262 Query: 292 ---SADGQTLFAGYTDNLVRVWQ 311 S L A D V+V+ Sbjct: 263 NFDSPMQSALIASSLDGHVKVFD 285 Score = 67.8 bits (164), Expect = 5e-12, Method: Composition-based stats. Identities = 24/180 (13%), Positives = 54/180 (30%), Gaps = 15/180 (8%) Query: 140 YTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVT 199 + Q V+ + F+P + V+ V++++ ++ + + + Sbjct: 31 TSAQLVKEHNSVTHISFNPQHPHDFAVTSS--TRVQIFSSRTRQVIKTFSRFKDVVYSAS 88 Query: 200 VSPDGSLCASGGKDGQAMLWDL--NEGKHLYTLDGGDIINALCFS--PNRYWLCAATGPS 255 DG L +G G ++D L + F N+ A+ Sbjct: 89 FRSDGKLLCAGDATGLVSVYDSYNPRTILLSINASTHPTHVTKFHTQDNKILATASDDRV 148 Query: 256 IKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLF-AGYTDNLVRVWQVTI 314 ++WD+ +L++ L G D L+R++ Sbjct: 149 TRLWDISNAYEPQ--------LELTGATDYVRTLSFIPAAPHLVATGSYDGLIRLYDTRS 200 Score = 52.4 bits (124), Expect = 2e-07, Method: Composition-based stats. Identities = 16/132 (12%), Positives = 42/132 (31%), Gaps = 11/132 (8%) Query: 187 NHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTL-DGGDIINALCFSPNR 245 + + ++ +P + + ++ + + T D++ + F + Sbjct: 34 QLVKEHNSVTHISFNPQHPHDFAVTSSTRVQIFSSRTRQVIKTFSRFKDVVYSASFRSDG 93 Query: 246 YWLCAATGPS-IKIWD-LEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYT 303 LCA + ++D + I+ + T Q D + L Sbjct: 94 KLLCAGDATGLVSVYDSYNPRTILLSINASTHPTHVTKFHTQ--------DNKILATASD 145 Query: 304 DNLVRVWQVTIG 315 D + R+W ++ Sbjct: 146 DRVTRLWDISNA 157 >4U1E-I nrPDB Length = 347 Score = 130 bits (326), Expect = 9e-31, Method: Composition-based stats. Identities = 55/326 (16%), Positives = 123/326 (37%), Gaps = 39/326 (11%) Query: 11 LKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVV 70 L GH +TQ+ + D++ S S+D + +W E L GH+ + + Sbjct: 6 LTGHERPLTQVKYNKE-GDLLFSCSKDSSASVWYSLNGER-----LGTLDGHTGTIWSID 59 Query: 71 ISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIK 130 + ++ ++GS D +++LWD++ G + V V FS + D +K Sbjct: 60 VDCFTKYCVTGSADYSIKLWDVSNGQCVATWKS-PVPVKRVEFSPCGNYFL-AILDNVMK 117 Query: 131 LWNTLGVCKYTVQDESHSEWVSCVRFSP------------------NSSNPIIVSCGWDK 172 N + Y ++ +S + ++ V P ++ I++ D Sbjct: 118 --NPGSINIYEIERDSATHELTKVSEEPIHKIITHEGLDAATVAGWSTKGKYIIAGHKDG 175 Query: 173 LVKVWNL-ANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLD 231 + +++ N + + H ++ + SPD + + +D + L D++ + L + Sbjct: 176 KISKYDVSNNYEYVDSIDLHEKSISDMQFSPDLTYFITSSRDTNSFLVDVSTLQVLKKYE 235 Query: 232 GGDIINALCFSPNRYWLCAATGP--------SIKIWDLEGKIIVDELKQEVISTSSKAEP 283 +N +P + ++ G S E + ++E+ + Sbjct: 236 TDCPLNTAVITPLKEFIILGGGQEAKDVTTTSANEGKFEARFYHKIFEEEIGRV--QGHF 293 Query: 284 PQCTSLAWSADGQTLFAGYTDNLVRV 309 ++A S G + +G D +R+ Sbjct: 294 GPLNTVAISPQGTSYASGGEDGFIRL 319 Score = 117 bits (294), Expect = 5e-27, Method: Composition-based stats. Identities = 43/186 (23%), Positives = 75/186 (40%), Gaps = 12/186 (6%) Query: 140 YTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVT 199 ++ H ++ V++ N ++ SC D VW N + GHTG + ++ Sbjct: 2 KAIKLTGHERPLTQVKY--NKEGDLLFSCSKDSSASVWYSLNGERLGTLDGHTGTIWSID 59 Query: 200 VSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATGP----- 254 V C +G D LWD++ G+ + T + + FSP + A Sbjct: 60 VDCFTKYCVTGSADYSIKLWDVSNGQCVATWKSPVPVKRVEFSPCGNYFLAILDNVMKNP 119 Query: 255 -SIKIWDLEGKIIVDEL---KQEVISTSSKAEPPQCTSLA-WSADGQTLFAGYTDNLVRV 309 SI I+++E EL +E I E ++A WS G+ + AG+ D + Sbjct: 120 GSINIYEIERDSATHELTKVSEEPIHKIITHEGLDAATVAGWSTKGKYIIAGHKDGKISK 179 Query: 310 WQVTIG 315 + V+ Sbjct: 180 YDVSNN 185 Score = 37.4 bits (85), Expect = 0.009, Method: Composition-based stats. Identities = 12/36 (33%), Positives = 17/36 (47%) Query: 58 ALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLT 93 ++GH ++ V IS G SG DG +RL Sbjct: 288 RVQGHFGPLNTVAISPQGTSYASGGEDGFIRLHHFE 323 Score = 35.4 bits (80), Expect = 0.034, Method: Composition-based stats. Identities = 21/146 (14%), Positives = 45/146 (30%), Gaps = 21/146 (14%) Query: 1 MTEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALR 60 ++ ++ H ++ + +P +++SRD + ++ + Sbjct: 182 VSNNYEYVDSIDLHEKSISDMQFSPDLT-YFITSSRDTNSFLVDVSTLQVLKKYETDC-- 238 Query: 61 GHSHFVSDVVISSDGQFALSGSW--------------DGTLRLWDLTTGTTTRRFVGHTK 106 ++ VI+ +F + G R + R GH Sbjct: 239 ----PLNTAVITPLKEFIILGGGQEAKDVTTTSANEGKFEARFYHKIFEEEIGRVQGHFG 294 Query: 107 DVLSVAFSSDNRQIVSGSRDKTIKLW 132 + +VA S SG D I+L Sbjct: 295 PLNTVAISPQGTSYASGGEDGFIRLH 320 Score = 32.7 bits (73), Expect = 0.23, Method: Composition-based stats. Identities = 9/44 (20%), Positives = 17/44 (38%) Query: 274 VISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGTR 317 + + T + ++ +G LF+ D+ VW G R Sbjct: 1 MKAIKLTGHERPLTQVKYNKEGDLLFSCSKDSSASVWYSLNGER 44 >5M89-A nrPDB Length = 329 Score = 127 bits (319), Expect = 6e-30, Method: Composition-based stats. Identities = 47/231 (20%), Positives = 91/231 (39%), Gaps = 19/231 (8%) Query: 74 DGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWN 133 + + A G DG L ++ + R + V + + ++V G+ +K+++ Sbjct: 62 ENECAAVGGLDGKLDIYSVVANKVERTLD-IGEPVTATEW--TGTKVVIGTAKGWVKVYD 118 Query: 134 TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTG 193 + + ++H+ V+ + P I+ S G DK ++L + Sbjct: 119 ---AGRESATFQTHAGPVTGLAVHP--GGRILASVGVDKSFVFYDLETGERVARGYA-DA 172 Query: 194 YLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATG 253 L T PDG+L A+G + G +++ + + G I AL FS N +W A Sbjct: 173 ALTTCAFHPDGNLFAAGTQTGHILVFHTTTLEQAESFPLGTPIQALAFSENGFWFAATGK 232 Query: 254 PS--IKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGY 302 + + I+DL K + + + + S++W GQ L G Sbjct: 233 GTSSVTIFDLR--------KSGAAAAVKELQTGEVLSISWDYTGQYLATGG 275 Score = 81.3 bits (199), Expect = 5e-16, Method: Composition-based stats. Identities = 34/242 (14%), Positives = 80/242 (33%), Gaps = 16/242 (6%) Query: 17 WVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQ 76 VT T ++ + + ++ R+ + H+ V+ + + G+ Sbjct: 94 PVTATEWT---GTKVVIGTAKGWVKVYDAGRE-------SATFQTHAGPVTGLAVHPGGR 143 Query: 77 FALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLG 136 S D + +DL TG R + + AF D +G++ I +++T Sbjct: 144 ILASVGVDKSFVFYDLETGERVAR-GYADAALTTCAFHPDGNLFAAGTQTGHILVFHTTT 202 Query: 137 VCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLA-NCKLKTNHIGHTGYL 195 + + + + + FS N + V +++L + TG + Sbjct: 203 LEQ--AESFPLGTPIQALAFSENG-FWFAATGKGTSSVTIFDLRKSGAAAAVKELQTGEV 259 Query: 196 NTVTVSPDGSLCASGGKDG-QAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATGP 254 +++ G A+GG G ++ + G + + + L + Sbjct: 260 LSISWDYTGQYLATGGGTGVTVQMYTKATKSWSEPVRLGMPVVGVKWGGEAKRLVVVSRE 319 Query: 255 SI 256 + Sbjct: 320 GV 321 Score = 69.0 bits (167), Expect = 3e-12, Method: Composition-based stats. Identities = 34/213 (15%), Positives = 76/213 (35%), Gaps = 15/213 (7%) Query: 9 GTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGH-SHFVS 67 T + H G VT +A P ++ S DK+ + + L E R RG+ ++ Sbjct: 124 ATFQTHAGPVTGLAVHP-GGRILASVGVDKSFVFYDLETGE-------RVARGYADAALT 175 Query: 68 DVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQI-VSGSRD 126 DG +G+ G + ++ TT F T + ++AFS + +G Sbjct: 176 TCAFHPDGNLFAAGTQTGHILVFHTTTLEQAESFPLGT-PIQALAFSENGFWFAATGKGT 234 Query: 127 KTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDK-LVKVWNLANCKLK 185 ++ +++ E + V + + + + + + G V+++ A Sbjct: 235 SSVTIFDLRKSGAAAAVKELQTGEVLSISW--DYTGQYLATGGGTGVTVQMYTKATKSW- 291 Query: 186 TNHIGHTGYLNTVTVSPDGSLCASGGKDGQAML 218 + + + V + ++G + Sbjct: 292 SEPVRLGMPVVGVKWGGEAKRLVVVSREGVVSV 324 Score = 52.0 bits (123), Expect = 3e-07, Method: Composition-based stats. Identities = 28/159 (17%), Positives = 50/159 (31%), Gaps = 19/159 (11%) Query: 159 NSSNPIIVSCGWDKLVKVWNLANCKLKTNH-IGHTGYLNTVTVSPDGSLCASGGKDGQAM 217 + N G D + ++++ K++ IG + + G+ G G Sbjct: 60 DLENECAAVGGLDGKLDIYSVVANKVERTLDIGE--PVTATEWT--GTKVVIGTAKGWVK 115 Query: 218 LWDLNEGKHLYTLDGG-DIINALCFSPNRYWLCAAT-GPSIKIWDLEGKIIVDELKQEVI 275 ++D G+ T + L P L + S +DLE V + Sbjct: 116 VYDA--GRESATFQTHAGPVTGLAVHPGGRILASVGVDKSFVFYDLETGERVARGYADAA 173 Query: 276 STSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTI 314 T+ A+ DG AG + V+ T Sbjct: 174 ----------LTTCAFHPDGNLFAAGTQTGHILVFHTTT 202 Score = 46.2 bits (108), Expect = 2e-05, Method: Composition-based stats. Identities = 24/119 (20%), Positives = 46/119 (38%), Gaps = 12/119 (10%) Query: 199 TVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKI 258 ++ + A GG DG+ ++ + K TLD G+ + A ++ + + A G +K+ Sbjct: 58 SLDLENECAAVGGLDGKLDIYSVVANKVERTLDIGEPVTATEWTGTKVVIGTAKGW-VKV 116 Query: 259 WDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGTR 317 +D S + + T LA G+ L + D + + G R Sbjct: 117 YD-----------AGRESATFQTHAGPVTGLAVHPGGRILASVGVDKSFVFYDLETGER 164 >4A11-B nrPDB Length = 408 Score = 127 bits (318), Expect = 8e-30, Method: Composition-based stats. Identities = 50/237 (21%), Positives = 98/237 (41%), Gaps = 26/237 (10%) Query: 104 HTKDVLSVAFSS-DNRQIVSGSRDKTIKLWNTLGVCKYTV------------QDESHSEW 150 H + ++ + R ++SG D I L++ + + + H Sbjct: 42 HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYS 101 Query: 151 VSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKL-KTNHIGHTGYLNTVT-VSPDGSLCA 208 V V++ P+ + + S +DK +KVW+ + + T Y + ++ VS L A Sbjct: 102 VETVQWYPHDTG-MFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVA 160 Query: 209 SGGKDGQAMLWDLNEGKHLYTLDGG-DIINALCFSPNRYWL--CAATGPSIKIWDLEGKI 265 G + + L DL G + L G I A+ +SP ++ A+ +K+WD+ Sbjct: 161 VGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRAS 220 Query: 266 -------IVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIG 315 + K + + +++ A + L +++DG L TDN +R+W + G Sbjct: 221 GCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNG 277 Score = 105 bits (261), Expect = 4e-23, Method: Composition-based stats. Identities = 61/330 (18%), Positives = 116/330 (35%), Gaps = 43/330 (13%) Query: 14 HNGWVTQIATTPQFPDMILSASRDKTIIMWKL--TRDETNYGIPQRALRG------HSHF 65 H G + + P +LS D I+++ L + ++ Y G H + Sbjct: 42 HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYS 101 Query: 66 VSDVVISS-DGQFALSGSWDGTLRLWDLTT-------GTTTRRFVGHTKDVLSVAFSSDN 117 V V D S S+D TL++WD T + H V S+ + Sbjct: 102 VETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPV-----STKH 156 Query: 118 RQIVSGSRDKTIKLWNTL-GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKV 176 + G+R ++L + G C + +Q H + + V +SP I+ + D VK+ Sbjct: 157 CLVAVGTRGPKVQLCDLKSGSCSHILQ--GHRQEILAVSWSPRYD-YILATASADSRVKL 213 Query: 177 WNLA----------------NCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWD 220 W++ + +++ + H G +N + + DG + G D + LW+ Sbjct: 214 WDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWN 273 Query: 221 LNEGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSK 280 + G+ TL + ++ + I V + T K Sbjct: 274 SSNGE--NTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLK 331 Query: 281 AEPPQCTSLAWSADGQTLFAGYTDNLVRVW 310 + ++ Q L++G D + W Sbjct: 332 GHYKTVDCCVFQSNFQELYSGSRDCNILAW 361 Score = 79.7 bits (195), Expect = 2e-15, Method: Composition-based stats. Identities = 36/183 (19%), Positives = 73/183 (39%), Gaps = 19/183 (10%) Query: 11 LKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRD-------ETNYGIPQRALR--- 60 L+GH + ++ +P++ ++ +AS D + +W + R + + G +A+ Sbjct: 182 LQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESAN 241 Query: 61 -GHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTT-----RRFVGHTKDVLSVAFS 114 H+ V+ + +SDG L+ D +RLW+ + G T + K + Sbjct: 242 TAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSC 301 Query: 115 SDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLV 174 + + V TI ++ + T+ + H + V C F N + S D + Sbjct: 302 GCSSEFVFVPYGSTIAVYTVYSGEQITM-LKGHYKTVDCCVFQSNFQE--LYSGSRDCNI 358 Query: 175 KVW 177 W Sbjct: 359 LAW 361 Score = 79.4 bits (194), Expect = 2e-15, Method: Composition-based stats. Identities = 30/185 (16%), Positives = 66/185 (35%), Gaps = 21/185 (11%) Query: 147 HSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIG-------------HTG 193 H ++ + P ++S G D ++ +++L N ++ + H Sbjct: 42 HGGGINTLDIEP-VEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRY 100 Query: 194 YLNTVTVSP-DGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAAT 252 + TV P D + S D +WD N + + + + + SP + Sbjct: 101 SVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSP-----VSTK 155 Query: 253 GPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQT-LFAGYTDNLVRVWQ 311 + + K+ + +LK S + + +++WS L D+ V++W Sbjct: 156 HCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWD 215 Query: 312 VTIGT 316 V + Sbjct: 216 VRRAS 220 Score = 34.7 bits (78), Expect = 0.055, Method: Composition-based stats. Identities = 16/75 (21%), Positives = 27/75 (36%), Gaps = 1/75 (1%) Query: 11 LKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVV 70 LKGH V F + + S SRD I+ W + E + + + + Sbjct: 330 LKGHYKTVDCCVFQSNFQE-LYSGSRDCNILAWVPSLYEPVPDDDETTTKSQLNPAFEDA 388 Query: 71 ISSDGQFALSGSWDG 85 SS + + +W Sbjct: 389 WSSSDEEGGTSAWSH 403 Score = 30.0 bits (66), Expect = 1.4, Method: Composition-based stats. Identities = 8/69 (11%), Positives = 25/69 (36%), Gaps = 1/69 (1%) Query: 250 AATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSA-DGQTLFAGYTDNLVR 308 +++ E V L+ + +L +G+ + +G +D ++ Sbjct: 10 TGLEDPLRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIV 69 Query: 309 VWQVTIGTR 317 ++ + +R Sbjct: 70 LYDLENSSR 78 >2AQ5-A nrPDB Length = 402 Score = 126 bits (316), Expect = 1e-29, Method: Composition-based stats. Identities = 46/224 (20%), Positives = 78/224 (34%), Gaps = 10/224 (4%) Query: 13 GHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRD--ETNYGIPQRALRGHSHFVSDVV 70 GH V IA P ++I S S D T+++W++ P L GH+ V V Sbjct: 79 GHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKRVGIVA 138 Query: 71 ISSD-GQFALSGSWDGTLRLWDLTTGTTTRRFVG--HTKDVLSVAFSSDNRQIVSGSRDK 127 LS D + +WD+ TG H + SV +S D I + RDK Sbjct: 139 WHPTAQNVLLSAGCDNVILVWDVGTGAAVLTLGPDVHPDTIYSVDWSRDGALICTSCRDK 198 Query: 128 TIKLWNTLGVCKYTVQDESH--SEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLK 185 +++ +D H + V V S S ++ V +W+ + + Sbjct: 199 RVRVIEPRKGTVVAEKDRPHEGTRPVHAVFVSEGKILTTGFSRMSERQVALWDTKHLEEP 258 Query: 186 TNHIGHTGYLNTVT--VSPDGSLC-ASGGKDGQAMLWDLNEGKH 226 + + PD ++ G D +++ Sbjct: 259 LSLQELDTSSGVLLPFFDPDTNIVYLCGKGDSSIRYFEITSEAP 302 Score = 89.8 bits (221), Expect = 2e-18, Method: Composition-based stats. Identities = 34/138 (24%), Positives = 55/138 (39%), Gaps = 18/138 (13%) Query: 190 GHTGYLNTVTVSP-DGSLCASGGKDGQAMLWDLNEG-------KHLYTLDGGDI-INALC 240 GHT + + P + ++ ASG +D M+W++ +G + + TL+G + + Sbjct: 79 GHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKRVGIVA 138 Query: 241 FSP--NRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTL 298 + P L A I +WD+ V L P S+ WS DG + Sbjct: 139 WHPTAQNVLLSAGCDNVILVWDVGTGAAVLTL-------GPDVHPDTIYSVDWSRDGALI 191 Query: 299 FAGYTDNLVRVWQVTIGT 316 D VRV + GT Sbjct: 192 CTSCRDKRVRVIEPRKGT 209 Score = 85.9 bits (211), Expect = 2e-17, Method: Composition-based stats. Identities = 36/186 (19%), Positives = 75/186 (40%), Gaps = 10/186 (5%) Query: 10 TLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDV 69 TL+GH V +A P +++LSA D I++W + + H + V Sbjct: 126 TLEGHTKRVGIVAWHPTAQNVLLSAGCDNVILVWDVGTGAAVLTLGPDV---HPDTIYSV 182 Query: 70 VISSDGQFALSGSWDGTLRLWDLTTGTTTR---RFVGHTKDVLSVAFSSDNRQIVSG--- 123 S DG + D +R+ + GT R T+ V +V F S+ + + +G Sbjct: 183 DWSRDGALICTSCRDKRVRVIEPRKGTVVAEKDRPHEGTRPVHAV-FVSEGKILTTGFSR 241 Query: 124 SRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCK 183 ++ + LW+T + + E + + F +N + + D ++ + + + Sbjct: 242 MSERQVALWDTKHLEEPLSLQELDTSSGVLLPFFDPDTNIVYLCGKGDSSIRYFEITSEA 301 Query: 184 LKTNHI 189 +++ Sbjct: 302 PFLHYL 307 >6CHG-A nrPDB Length = 312 Score = 123 bits (308), Expect = 1e-28, Method: Composition-based stats. Identities = 52/259 (20%), Positives = 108/259 (41%), Gaps = 19/259 (7%) Query: 67 SDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRD 126 + IS DG+ + + ++++++ + H + + + +S D++ I SGS D Sbjct: 17 TSCQISPDGELIAIC-QNTDMLVYEISSSKMMKLTTTHKECINCLCWSPDSKCIASGSED 75 Query: 127 KTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKT 186 T+++ T + + H+ V + + N+ I+ S D+ +K W++ + Sbjct: 76 FTVEI--THIIYGRIRRLMGHTAPVISICY--NNKGNILCSSSMDESIKEWHVLSGTALK 131 Query: 187 NHIGHTGYLNTVTVSP-DGSLCASGGKDGQAMLWDLNEGKHLYTL---------DGGDII 236 H+ + ++ + D S+ +SG DG ++D G L TL DG I Sbjct: 132 TMSAHSDAVVSIDIPKFDSSILSSGSYDGLIRIFDTESGHCLKTLTYDKDWIAEDGVVPI 191 Query: 237 NALCFSPNR-YWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADG 295 + + FS N + L + +K+W+ +V T +K + L + G Sbjct: 192 STVKFSRNGKFLLVKSLDNVVKLWEYTRGTVVRTFLWPHQETKAKLKYNCGLELIY-PQG 250 Query: 296 Q--TLFAGYTDNLVRVWQV 312 + + +G + VW V Sbjct: 251 KDPLVISGNDSGSMCVWNV 269 Score = 112 bits (280), Expect = 2e-25, Method: Composition-based stats. Identities = 54/248 (21%), Positives = 97/248 (39%), Gaps = 30/248 (12%) Query: 2 TEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRG 61 ++ M L T H + + +P I S S D T+ + R L G Sbjct: 44 SKMMKLTTT---HKECINCLCWSPD-SKCIASGSEDFTVEI------THIIYGRIRRLMG 93 Query: 62 HSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSS-DNRQI 120 H+ V + ++ G S S D +++ W + +GT + H+ V+S+ D+ + Sbjct: 94 HTAPVISICYNNKGNILCSSSMDESIKEWHVLSGTALKTMSAHSDAVVSIDIPKFDSSIL 153 Query: 121 VSGSRDKTIKLWNTL-GVCKYTVQDESH------SEWVSCVRFSPNSSNPIIVSCGWDKL 173 SGS D I++++T G C T+ + +S V+FS N ++ S D + Sbjct: 154 SSGSYDGLIRIFDTESGHCLKTLTYDKDWIAEDGVVPISTVKFSRNGKFLLVKS--LDNV 211 Query: 174 VKVWNLANCKLKTNHI-GHTGYLNTVTVS-------PDGS--LCASGGKDGQAMLWDLNE 223 VK+W + + H + + P G L SG G +W++ Sbjct: 212 VKLWEYTRGTVVRTFLWPHQETKAKLKYNCGLELIYPQGKDPLVISGNDSGSMCVWNVYS 271 Query: 224 GKHLYTLD 231 + +D Sbjct: 272 KNLVQKID 279 Score = 108 bits (269), Expect = 4e-24, Method: Composition-based stats. Identities = 45/229 (19%), Positives = 89/229 (38%), Gaps = 22/229 (9%) Query: 9 GTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSD 68 L GH V I + +++ S+S D++I W + G + + HS V Sbjct: 89 RRLMGHTAPVISICYNNK-GNILCSSSMDESIKEWHVLS-----GTALKTMSAHSDAVVS 142 Query: 69 VVISS-DGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDV--------LSVAFSSDNRQ 119 + I D SGS+DG +R++D +G + + +V FS + + Sbjct: 143 IDIPKFDSSILSSGSYDGLIRIFDTESGHCLKTLTYDKDWIAEDGVVPISTVKFSRNGKF 202 Query: 120 IVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFS-------PNSSNPIIVSCGWDK 172 ++ S D +KLW H E + ++++ P +P+++S Sbjct: 203 LLVKSLDNVVKLWEYTRGTVVRTFLWPHQETKAKLKYNCGLELIYPQGKDPLVISGNDSG 262 Query: 173 LVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDL 221 + VWN+ + L +++S A+ +G+ L+ + Sbjct: 263 SMCVWNVYSKNLVQKIDEKHRNSPLISISASYDKVATLSLNGECNLFRV 311 Score = 98.6 bits (244), Expect = 3e-21, Method: Composition-based stats. Identities = 42/211 (19%), Positives = 84/211 (39%), Gaps = 9/211 (4%) Query: 109 LSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSC 168 S S D I + ++ + +H E ++C+ +SP+S I S Sbjct: 17 TSCQISPDGELIAICQNTDML-VYEISSSKMMKLTT-THKECINCLCWSPDS--KCIASG 72 Query: 169 GWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLY 228 D V++ ++ + +GHT + ++ + G++ S D W + G L Sbjct: 73 SEDFTVEITHIIYGR-IRRLMGHTAPVISICYNNKGNILCSSSMDESIKEWHVLSGTALK 131 Query: 229 TLDGGDIINALCFSP--NRYWLCAAT-GPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQ 285 T+ P + L + + I+I+D E + L + + P Sbjct: 132 TMSAHSDAVVSIDIPKFDSSILSSGSYDGLIRIFDTESGHCLKTLTYDKDWIAEDGVVP- 190 Query: 286 CTSLAWSADGQTLFAGYTDNLVRVWQVTIGT 316 +++ +S +G+ L DN+V++W+ T GT Sbjct: 191 ISTVKFSRNGKFLLVKSLDNVVKLWEYTRGT 221 >5FA5-B nrPDB Length = 367 Score = 119 bits (297), Expect = 2e-27, Method: Composition-based stats. Identities = 50/247 (20%), Positives = 91/247 (36%), Gaps = 7/247 (2%) Query: 15 NGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSD 74 V + + IL AS + +W+L +ET + + H VS V + S Sbjct: 105 EAGVADLTWVGERG--ILVASDSGAVELWELDENETLI-VSKFCKYEHDDIVSTVSVLSS 161 Query: 75 GQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNR-QIVSGSRDKTIKLWN 133 G A+SGS D +++WDL + H V VA S +S S D I LW+ Sbjct: 162 GTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWD 221 Query: 134 TLGVCKYT-VQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHT 192 T + + + + + + P S + + V + + + + H+ Sbjct: 222 TRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVF-GDENGTVSLVDTKSTSCVLSSAVHS 280 Query: 193 GYLNTVTVSPDG-SLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAA 251 + + SP AS +D + D + + + D + +SP + L Sbjct: 281 QCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQAHRDFVRDATWSPLNHSLLTT 340 Query: 252 TGPSIKI 258 G ++ Sbjct: 341 VGWDHQV 347 Score = 79.7 bits (195), Expect = 2e-15, Method: Composition-based stats. Identities = 34/173 (19%), Positives = 70/173 (40%), Gaps = 8/173 (4%) Query: 4 QMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHS 63 Q + + + H VT +A +P + LS S D I++W + I A Sbjct: 181 QQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSA---PG 237 Query: 64 HFVSDVVISSDGQFALS-GSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDN-RQIV 121 + + + G +GT+ L D + + H++ V + FS + + Sbjct: 238 YLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLA 297 Query: 122 SGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLV 174 S S D ++ + + + ++H ++V +SP ++ ++ + GWD V Sbjct: 298 SLSEDCSLAVLD--SSLSELFRSQAHRDFVRDATWSP-LNHSLLTTVGWDHQV 347 Score = 50.1 bits (118), Expect = 1e-06, Method: Composition-based stats. Identities = 27/129 (20%), Positives = 51/129 (39%), Gaps = 17/129 (13%) Query: 192 TGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLY-----TLDGGDIINALC-FSPNR 245 + +T + + G LW+L+E + L + DI++ + S Sbjct: 105 EAGVADLTWVGERGILV-ASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGT 163 Query: 246 YWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLF-AGYTD 304 + + IK+WD L Q+V+ +S +A Q T +A S ++F + D Sbjct: 164 QAVSGSKDICIKVWD---------LAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSED 214 Query: 305 NLVRVWQVT 313 N + +W Sbjct: 215 NRILLWDTR 223 Score = 45.5 bits (106), Expect = 3e-05, Method: Composition-based stats. Identities = 15/91 (16%), Positives = 35/91 (38%), Gaps = 5/91 (5%) Query: 222 NEGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKA 281 NEG + + L + R L A+ ++++W+L+ + V Sbjct: 94 NEGFCSAGVQTEAGVADLTWVGERGILVASDSGAVELWELDENETLI-----VSKFCKYE 148 Query: 282 EPPQCTSLAWSADGQTLFAGYTDNLVRVWQV 312 ++++ + G +G D ++VW + Sbjct: 149 HDDIVSTVSVLSSGTQAVSGSKDICIKVWDL 179 >6ELZ-p nrPDB Length = 460 Score = 117 bits (294), Expect = 5e-27, Method: Composition-based stats. Identities = 67/327 (20%), Positives = 115/327 (35%), Gaps = 49/327 (14%) Query: 15 NGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSD 74 WV+ + I+S S D + W L+ G Q+ GHS + V S+ Sbjct: 103 EDWVSSLDV-GDGSKHIISGSYDGIVRTWDLS------GNVQKQYSGHSGPIRAVKYISN 155 Query: 75 GQFALSGSWDGTLRLW-----------------------DLTTGTTTRRFVGHTKDVLSV 111 + +S D TLRLW ++ G T GH V+S+ Sbjct: 156 TR-LVSAGNDRTLRLWKTKNDDLKLTSQQQAQEDDDDEVNIEDGKTLAILEGHKAPVVSI 214 Query: 112 AFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQ-DESHSEWVSCVRFSPNSSNPIIVSCGW 170 S DN +I+S S D +I W+T+ V E + + + + + + Sbjct: 215 DVS-DNSRILSASYDNSIGFWSTIYKEMTVVDPLEDINNPNNKISTAARKRRKLTM---K 270 Query: 171 DKLVKVWNLANCKLKTNHIGHTGYLNTVTV-SPDGSLCASGGKDGQAMLWDLNEGKHLYT 229 D ++ + HT + V S D ++ S +D WDL + + T Sbjct: 271 DGTIR-----RRAPLSLLESHTAPVEQVIFDSTDNTVGYSVSQDHTIKTWDLVTARCIDT 325 Query: 230 LDGGDIINALC-FSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTS 288 + ++ S C ++ I + D +Q++I +S Sbjct: 326 RTTSYSLLSIAQLSTLNLLACGSSARHITLHDPRVGASSKVTQQQLI-----GHKNFVSS 380 Query: 289 LAWSADGQT-LFAGYTDNLVRVWQVTI 314 L + + L +G D V+VW V Sbjct: 381 LDTCPENEYILCSGSHDGTVKVWDVRS 407 Score = 83.2 bits (204), Expect = 1e-16, Method: Composition-based stats. Identities = 41/178 (23%), Positives = 69/178 (38%), Gaps = 21/178 (11%) Query: 11 LKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVV 70 L+ H V Q+ + S S+D TI W L S+ + + Sbjct: 283 LESHTAPVEQVIFDSTDNTVGYSVSQDHTIKTWDLVTARCIDTRTT------SYSLLSIA 336 Query: 71 ISSDGQFALSGSWDGTLRLWD----LTTGTTTRRFVGHTKDVLSVAFSSDNRQI-VSGSR 125 S GS + L D ++ T ++ +GH V S+ +N I SGS Sbjct: 337 QLSTLNLLACGSSARHITLHDPRVGASSKVTQQQLIGHKNFVSSLDTCPENEYILCSGSH 396 Query: 126 DKTIKLWNTLGVCK-YTVQDE------SHSEWVSCVRFSPNSSNPIIVSCGWDKLVKV 176 D T+K+W+ YT+ E ++ V V+++ I+S G DK +++ Sbjct: 397 DGTVKVWDVRSTSPMYTITREDKSVQKGVNDKVFAVKWA---EKVGIISAGQDKKIQI 451 Score = 80.9 bits (198), Expect = 8e-16, Method: Composition-based stats. Identities = 39/235 (16%), Positives = 81/235 (34%), Gaps = 41/235 (17%) Query: 106 KDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPII 165 V S+ ++ I+SGS D ++ W+ G + Q HS + V++ N+ + Sbjct: 104 DWVSSLDVGDGSKHIISGSYDGIVRTWDLSGNVQK--QYSGHSGPIRAVKYISNTR---L 158 Query: 166 VSCGWDKLVKVW-----------------------NLANCKLKTNHIGHTGYLNTVTVSP 202 VS G D+ +++W N+ + K GH + ++ VS Sbjct: 159 VSAGNDRTLRLWKTKNDDLKLTSQQQAQEDDDDEVNIEDGKTLAILEGHKAPVVSIDVS- 217 Query: 203 DGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLE 262 D S S D W + D + + +PN AA + Sbjct: 218 DNSRILSASYDNSIGFWST----IYKEMTVVDPLEDIN-NPNNKISTAARKRR------K 266 Query: 263 GKIIVDELKQEVISTSSKAEPPQCTSLAW-SADGQTLFAGYTDNLVRVWQVTIGT 316 + +++ + ++ + + S D ++ D+ ++ W + Sbjct: 267 LTMKDGTIRRRAPLSLLESHTAPVEQVIFDSTDNTVGYSVSQDHTIKTWDLVTAR 321 Score = 59.3 bits (142), Expect = 2e-09, Method: Composition-based stats. Identities = 18/87 (20%), Positives = 37/87 (42%), Gaps = 4/87 (4%) Query: 6 TLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIP---QRALRGH 62 + L GH +V+ + T P+ ++ S S D T+ +W + Y I + +G Sbjct: 366 VTQQQLIGHKNFVSSLDTCPENEYILCSGSHDGTVKVWDVRSTSPMYTITREDKSVQKGV 425 Query: 63 SHFVSDVVISSDGQFALSGSWDGTLRL 89 + V V + + +S D +++ Sbjct: 426 NDKVFAVKWA-EKVGIISAGQDKKIQI 451 Score = 38.5 bits (88), Expect = 0.004, Method: Composition-based stats. Identities = 11/91 (12%), Positives = 30/91 (32%), Gaps = 12/91 (13%) Query: 227 LYTLDGGDIINALCFSP-NRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQ 285 L + D +++L +++ + + ++ WDL G + Sbjct: 97 LNSFSNEDWVSSLDVGDGSKHIISGSYDGIVRTWDLSGNVQKQ----------YSGHSGP 146 Query: 286 CTSLAWSADGQTLFAGYTDNLVRVWQVTIGT 316 ++ + L + D +R+W+ Sbjct: 147 IRAVKY-ISNTRLVSAGNDRTLRLWKTKNDD 176 >4XFV-A nrPDB Length = 792 Score = 115 bits (289), Expect = 2e-26, Method: Composition-based stats. Identities = 62/373 (16%), Positives = 124/373 (33%), Gaps = 82/373 (21%) Query: 8 RGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVS 67 TLKGH VT + P D ++SAS D + +WK T + ++ + ++ +S + Sbjct: 56 YATLKGHEAEVTCVRFVPD-SDFMVSASEDHHVKIWKFT--DYSHLQCIQTIQHYSKTIV 112 Query: 68 DVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDV---------LSVAFSSDNR 118 + G DGT+ +W H + LS++ + + Sbjct: 113 ALSALPS--LISVGCADGTISIWRQNIQNDEFGL-AHEFTIKKGFFYPLCLSLSKVEEKK 169 Query: 119 QIVSGSRDKT-------IKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSS--NPIIVSCG 169 +++ I + + C+ + E H +WV + F + + ++ S Sbjct: 170 YLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGS 229 Query: 170 WDKLVKVW---------NLANCKLKTNHI------------------------GHTGYLN 196 D+ +++W + K + GH +++ Sbjct: 230 QDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWIS 289 Query: 197 TVTVSPDGSLCASGGKDGQAMLWD-----------------LNEGKHLYTLDGGDIINAL 239 ++ + D M+W+ ++G T G + L Sbjct: 290 SLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCL 349 Query: 240 CFSPNR--YWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQT 297 F+ R ++L S ++W + II D+ T +AWS G+ Sbjct: 350 WFTHERMDFFLTNGKTGSWRMWATKDNIICDQ------RLGISGATKDVTDIAWSPSGEY 403 Query: 298 LFAGYTDNLVRVW 310 L A D R++ Sbjct: 404 LLATSLDQTTRLF 416 Score = 101 bits (252), Expect = 3e-22, Method: Composition-based stats. Identities = 60/335 (17%), Positives = 111/335 (33%), Gaps = 50/335 (14%) Query: 1 MTEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALR 60 M E +T G TQ++ + ++ + KTI +W E N L+ Sbjct: 5 MVECITPEAIFIG-ANKQTQVSDIHKVKKIVAFGA-GKTIALWDPI--EPNNKGVYATLK 60 Query: 61 GHSHFVSDVVISSDGQFALSGSWDGTLRLW---DLTTGTTTRRFVGHTKDVLSVAFSSDN 117 GH V+ V D F +S S D +++W D + + ++K +++++ Sbjct: 61 GHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALP-- 118 Query: 118 RQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVS-------CVRFSPNSSNPIIVSCGW 170 I G D TI +W + +H + C+ S +++ G Sbjct: 119 SLISVGCADGTISIW--RQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGG 176 Query: 171 DKLVKVW---------NLANCKLKTNHIGHTGYLNTVTV----SPDGSLCASGGKDGQAM 217 V V+ + C++ GH ++ ++ +P L SG +D Sbjct: 177 -TNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIR 235 Query: 218 LWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEV-IS 276 LW + + + L + + I DEL+ + Sbjct: 236 LWRIRINDLIDDSEEDSKKLTLLSNKQYKF-----------------QIDDELRVGINFE 278 Query: 277 TSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQ 311 +SL W L A D + VW+ Sbjct: 279 ALIMGHDDWISSLQWHESRLQLLAATADTSLMVWE 313 Score = 92.5 bits (228), Expect = 2e-19, Method: Composition-based stats. Identities = 45/217 (20%), Positives = 86/217 (39%), Gaps = 22/217 (10%) Query: 118 RQIVSGSRDKTIKLWNTLGVCKY--TVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVK 175 ++IV+ KTI LW+ + + H V+CVRF P+S +VS D VK Sbjct: 31 KKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSD--FMVSASEDHHVK 88 Query: 176 VW---NLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG 232 +W + ++ + ++ + ++ P SL + G DG +W N + L Sbjct: 89 IWKFTDYSHLQCIQTIQHYSKTIVALSALP--SLISVGCADGTISIWRQNIQNDEFGLAH 146 Query: 233 GDIINALCFSP---------NRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEP 283 I F P + +L A G ++ ++ + +++ + + Sbjct: 147 EFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHE 206 Query: 284 PQCTSLAW----SADGQTLFAGYTDNLVRVWQVTIGT 316 SLA+ + L +G D +R+W++ I Sbjct: 207 DWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRIND 243 Score = 84.0 bits (206), Expect = 7e-17, Method: Composition-based stats. Identities = 52/237 (21%), Positives = 90/237 (37%), Gaps = 31/237 (13%) Query: 11 LKGHNGWVTQIATTPQFPDMILSASRDKT-----IIMWKLTRDETNYGIPQRALRGHSHF 65 L GH +T + +P +I SA R I ++ N+ + AL HS Sbjct: 558 LYGHGFEITCLDISPDQK-LIASACRSNNVQNAVIRIFS----TENWLEIKPALPFHSLT 612 Query: 66 VSDVVISSDGQFALSGSWDGTLRLW--DLTTGTTTRRFVG---HTKDVLSVAFSS--DNR 118 ++ + S DG+F LS D LW ++ T RF HT+ + ++ Sbjct: 613 ITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGN 672 Query: 119 QIVSGSRDKTIKLWNTLGVCKYTVQDES---HSEWVSCVRFSPN-SSNPIIVSCGWDK-- 172 V+ SRDKT+K+W E+ H++ V+ + + I++S G + Sbjct: 673 VFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGE 732 Query: 173 -LVKVWNLANCKLKTNHIGH---TGYLNTVTVS---PDGSLCA-SGGKDGQAMLWDL 221 + + L +L T + + S +G L G D ++ L Sbjct: 733 IYLYSYTLGKFELITQLNEDITPADKITRLRWSHLKRNGKLFLGVGSSDLSTRIYSL 789 Score = 75.5 bits (184), Expect = 3e-14, Method: Composition-based stats. Identities = 56/396 (14%), Positives = 122/396 (30%), Gaps = 94/396 (23%) Query: 3 EQMTLRGTLKGHNGWVTQIATTPQ---FPDMILSASRDKTIIMWKLTR----DETNYGIP 55 E+ + L+GH WV +A Q ++ S S+D+ I +W++ D++ Sbjct: 194 EKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSK 253 Query: 56 QRAL------------------------RGHSHFVSDVVISSDGQFALSGSWDGTLRLWD 91 + L GH ++S + L+ + D +L +W+ Sbjct: 254 KLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWE 313 Query: 92 LT---------------TGTTTRRFVGHTKDVLSVAF--SSDNRQIVSGSRDKTIKLWNT 134 + G + S + ++ + + ++W T Sbjct: 314 PDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWAT 373 Query: 135 LG--VCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVK-----VWNLANCKLKTN 187 +C + ++ V+ + +SP S +++ D+ + +++ + K + Sbjct: 374 KDNIICDQRLGISGATKDVTDIAWSP--SGEYLLATSLDQTTRLFAPWIYDASGRKREIA 431 Query: 188 HIG-------HTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEG-------------KHL 227 H + V D SGG + +DL +G + Sbjct: 432 TWHEFSRPQIHGYDMICVETVTDTR-FVSGGDEKILRSFDLPKGVAGMLQKFVGIQFEEK 490 Query: 228 YTLDGGDIINALCFSPN---------RYWLCAATGPSIKIWD----LEGKIIVDELKQEV 274 + + L S + I D LE + D+L++ + Sbjct: 491 SEMPDSATVPVLGLSNKAGEDDANEDDEEEEGGNKETPDITDPLSLLECPPMEDQLQRHL 550 Query: 275 I---STSSKAEPPQCTSLAWSADGQTLFAGYTDNLV 307 + + T L S D + + + N V Sbjct: 551 LWPEVEKLYGHGFEITCLDISPDQKLIASACRSNNV 586 Score = 65.1 bits (157), Expect = 4e-11, Method: Composition-based stats. Identities = 61/327 (18%), Positives = 110/327 (33%), Gaps = 50/327 (15%) Query: 11 LKGHNGWVTQIATTPQFPDMILSASRDKTIIMW-------KLTRDETNYGIPQRALRGHS 63 + G VT IA +P + +L+ S D+T ++ + E + H Sbjct: 385 ISGATKDVTDIAWSPS-GEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHG 443 Query: 64 HFVSDVVISSDGQFALSGSWDGTLRLWDLTTG--TTTRRFVGHTKDVLSVAFSSDNRQIV 121 + + V +D +F SG + LR +DL G ++FVG + F + Sbjct: 444 YDMICVETVTDTRFV-SGGDEKILRSFDLPKGVAGMLQKFVG-------IQFEEKSEMPD 495 Query: 122 SGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPI-IVSCG--WDKLVK--V 176 S T+ + +E E + +P+ ++P+ ++ C D+L + + Sbjct: 496 SA----TVPVLGLSNKAGEDDANEDDEEEEGGNKETPDITDPLSLLECPPMEDQLQRHLL 551 Query: 177 WNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQA-----MLWDLNEGKHLY-TL 230 W GH + + +SPD L AS + ++ + L Sbjct: 552 W-----PEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPAL 606 Query: 231 DGGD-IINALCFSPNR-YWLCAATGPSIKIW--DLEGKIIVDELKQEVISTSSKAEPPQC 286 I L FS + + L +W ++E K E K Sbjct: 607 PFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNE------KPHTRII 660 Query: 287 TSLAWSAD--GQTLFAGYTDNLVRVWQ 311 W+ G D V+VW+ Sbjct: 661 WDADWAPLEFGNVFVTASRDKTVKVWR 687 Score = 62.0 bits (149), Expect = 4e-10, Method: Composition-based stats. Identities = 37/237 (15%), Positives = 87/237 (36%), Gaps = 28/237 (11%) Query: 100 RFVGHTKDVLSVAFSSDNRQIVSGSRDKT-----IKLWNTLGVCKYTVQDESHSEWVSCV 154 + GH ++ + S D + I S R I++++T + HS ++ + Sbjct: 557 KLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRL 616 Query: 155 RFSPNSSNPIIVSCGWDKLVKVWNL----ANCKLKTNHI-GHTGYLNTVTVSP--DGSLC 207 +FS + ++S D+ +W +L+ + HT + +P G++ Sbjct: 617 KFSKDG--KFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVF 674 Query: 208 ASGGKDGQAMLWDLNEGKH-----LYTLDGGDIINALCFSPN---RYWLCAATGPSIKIW 259 + +D +W + ++ + A+ + L + + +I+ Sbjct: 675 VTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIY 734 Query: 260 DLEGKIIVDELKQEVISTSSKAEPPQCTSLAWS---ADGQTLF-AGYTDNLVRVWQV 312 + EL ++ + A + T L WS +G+ G +D R++ + Sbjct: 735 LYSYTLGKFELITQLNEDITPA--DKITRLRWSHLKRNGKLFLGVGSSDLSTRIYSL 789 Score = 46.6 bits (109), Expect = 1e-05, Method: Composition-based stats. Identities = 12/73 (16%), Positives = 28/73 (38%), Gaps = 6/73 (8%) Query: 242 SPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAG 301 + + G +I +WD E + + + K + T + + D + + Sbjct: 28 HKVKKIVAFGAGKTIALWD------PIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSA 81 Query: 302 YTDNLVRVWQVTI 314 D+ V++W+ T Sbjct: 82 SEDHHVKIWKFTD 94 >4G56-B nrPDB Length = 357 Score = 113 bits (282), Expect = 1e-25, Method: Composition-based stats. Identities = 51/232 (21%), Positives = 91/232 (39%), Gaps = 7/232 (3%) Query: 15 NGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSD 74 VT +A + IL AS + +W++ E+ + + A H V + + SD Sbjct: 94 EAGVTDVAWVSEKG--ILVASDSGAVELWEILEKESLL-VNKFAKYEHDDIVKTLSVFSD 150 Query: 75 GQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNR-QIVSGSRDKTIKLWN 133 G A+SG D ++++WDL+ + + H+ +V VA +S D I LW+ Sbjct: 151 GTQAVSGGKDFSVKVWDLSQKAVLKSYNAHSSEVNCVAACPGKDTIFLSCGEDGRILLWD 210 Query: 134 TLGVCKYTVQDESHSEWV-SCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHT 192 T T D S+ + + V + P + V + N+ N H+ Sbjct: 211 TRKPKPATRIDFCASDTIPTSVTWHPEKDD-TFACGDETGNVSLVNIKNPDSAQTSAVHS 269 Query: 193 GYLNTVTVSPDGS-LCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSP 243 + + S S AS +D + D + + L D + + +SP Sbjct: 270 QNITGLAYSYHSSPFLASISEDCTVAVLDADFSEVFRDLSHRDFVTGVAWSP 321 Score = 75.9 bits (185), Expect = 2e-14, Method: Composition-based stats. Identities = 33/175 (18%), Positives = 67/175 (38%), Gaps = 8/175 (4%) Query: 2 TEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRG 61 Q + + H+ V +A P + LS D I++W + + I Sbjct: 168 LSQKAVLKSYNAHSSEVNCVAACPGKDTIFLSCGEDGRILLWDTRKPKPATRI---DFCA 224 Query: 62 HSHFVSDVVISSDG-QFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFS-SDNRQ 119 + V + G G + L ++ + + H++++ +A+S + Sbjct: 225 SDTIPTSVTWHPEKDDTFACGDETGNVSLVNIKNPDSAQTSAVHSQNITGLAYSYHSSPF 284 Query: 120 IVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLV 174 + S S D T+ + + +D SH ++V+ V +SP + + GWD V Sbjct: 285 LASISEDCTVAVLD--ADFSEVFRDLSHRDFVTGVAWSPLDHSK-FTTVGWDHKV 336 Score = 48.2 bits (113), Expect = 5e-06, Method: Composition-based stats. Identities = 23/130 (17%), Positives = 42/130 (32%), Gaps = 17/130 (13%) Query: 192 TGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHL-----YTLDGGDIINALC-FSPNR 245 + V + + G LW++ E + L + DI+ L FS Sbjct: 94 EAGVTDVAWVSEKGILV-ASDSGAVELWEILEKESLLVNKFAKYEHDDIVKTLSVFSDGT 152 Query: 246 YWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLF-AGYTD 304 + S+K+WDL K ++ A + +A T+F + D Sbjct: 153 QAVSGGKDFSVKVWDLSQKAVLKSY---------NAHSSEVNCVAACPGKDTIFLSCGED 203 Query: 305 NLVRVWQVTI 314 + +W Sbjct: 204 GRILLWDTRK 213 Score = 45.5 bits (106), Expect = 3e-05, Method: Composition-based stats. Identities = 16/105 (15%), Positives = 39/105 (37%), Gaps = 10/105 (9%) Query: 214 GQAMLWDLNEGK-----HLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVD 268 G ++ EG + + + + + L A+ ++++W++ K + Sbjct: 70 GSIWVFKDPEGAPNESLCTAGVQTEAGVTDVAWVSEKGILVASDSGAVELWEILEKESLL 129 Query: 269 ELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVT 313 K + +L+ +DG +G D V+VW ++ Sbjct: 130 VNK-----FAKYEHDDIVKTLSVFSDGTQAVSGGKDFSVKVWDLS 169 >5A9Q-7 nrPDB Length = 360 Score = 112 bits (281), Expect = 2e-25, Method: Composition-based stats. Identities = 51/298 (17%), Positives = 108/298 (36%), Gaps = 46/298 (15%) Query: 62 HSHFVSDVVISSDGQFALSGSWDGTLRLWD---LTTGTTTRRFVGHTKDVLSVAFS--SD 116 H + DV G+ + S D ++++WD T + H+ V V ++ Sbjct: 11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEF 70 Query: 117 NRQIVSGSRDKTIKLW-NTLGVCKYTVQDESH----------SEWVSCVRFSPNSSNPII 165 + + S S D+T +W +G ++ +SH V+ V+F+P ++ Sbjct: 71 GQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLML 130 Query: 166 VSCGWDKLVKVWNLA-----NCKLKTNHIGHTGYLNTVTVSPDGS-----LCASGGKD-- 213 +C D +V+++ + + I + ++ +P S + A G D Sbjct: 131 ATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSPMIAVGSDDSS 190 Query: 214 ----GQAMLWDLNEGKHLYT-----LDGGDIINALCFSPN---RYWLCAATGPSIKIWDL 261 + +++ NE Y + D ++ + F+PN + + A ++I+ L Sbjct: 191 PNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAIATKDVRIFTL 250 Query: 262 EGKIIVDELKQEVISTSSK------AEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVT 313 + Q ++W+ G L + D VR+W+ Sbjct: 251 KPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWKAN 308 Score = 91.7 bits (226), Expect = 4e-19, Method: Composition-based stats. Identities = 50/278 (17%), Positives = 102/278 (36%), Gaps = 48/278 (17%) Query: 8 RGTLKGHNGWVTQIAT-TPQFPDMILSASRDKTIIMWKLTRDETN-------YGIPQRAL 59 + K H+G V ++ P+F ++ S S D+T +W+ E+N + + + L Sbjct: 50 TASWKTHSGSVWRVTWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTL 109 Query: 60 RGHSHFVSDVVISSD--GQFALSGSWDGTLRLWDLTTGTTTRRFVGH-----TKDVLSVA 112 V+DV + G + S DG +R+++ ++ ++ Sbjct: 110 VDSRTSVTDVKFAPKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCIS 169 Query: 113 FSSDNRQ-----IVSGSRDK------TIKLWNTLGVCKYTVQDESH---SEWVSCVRFSP 158 ++ + + I GS D ++++ + + E+ ++ V + F+P Sbjct: 170 WNPSSSRAHSPMIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAP 229 Query: 159 NSSNPIIVSCGWDKLVKVWNLANCKLKTN---------------HIGHTGYLNTVTVSPD 203 N + K V+++ L + + H + V+ + Sbjct: 230 NLGRSFHILAIATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNIT 289 Query: 204 GSLCASGGKDGQAMLWDLN---EGKHLYTLDG-GDIIN 237 G++ AS G DG LW N K L G G +N Sbjct: 290 GTVLASSGDDGCVRLWKANYMDNWKCTGILKGNGSPVN 327 Score = 40.4 bits (93), Expect = 0.001, Method: Composition-based stats. Identities = 19/88 (21%), Positives = 33/88 (37%), Gaps = 9/88 (10%) Query: 231 DGGDIINALCFSPN-RYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSL 289 D D+I+ + F + R ++ S+K+WD + S K + Sbjct: 10 DHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESG------DWHCTASWKTHSGSVWRV 63 Query: 290 AWS--ADGQTLFAGYTDNLVRVWQVTIG 315 W+ GQ L + D VW+ +G Sbjct: 64 TWAHPEFGQVLASCSFDRTAAVWEEIVG 91 Score = 32.4 bits (72), Expect = 0.26, Method: Composition-based stats. Identities = 6/41 (14%), Positives = 16/41 (39%) Query: 274 VISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTI 314 V + + +++ G+ + +D V+VW + Sbjct: 3 VARSIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSE 43 >5N4A-A nrPDB Length = 771 Score = 112 bits (280), Expect = 2e-25, Method: Composition-based stats. Identities = 48/289 (16%), Positives = 105/289 (36%), Gaps = 20/289 (6%) Query: 14 HNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRG--HSHFVSDVVI 71 H+ + + + + S D+TI W + + A H + VS Sbjct: 13 HSELTAAVGWNVW--NELFTCSDDQTIHKWNMLGEPEQKVSTLDAYFTDMHWYPVSSKKT 70 Query: 72 SSDG-QFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIK 130 + G DG++++ TG + GH +S+ +S D + + D ++K Sbjct: 71 QAGGTDVFAVACTDGSVKILS-RTGRVEKSIEGHKGACISLRWSYDGTALATAGEDGSVK 129 Query: 131 LWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIG 190 +W+ G+ + T+ V + ++ + + V + +L++ + Sbjct: 130 IWSRNGMLRSTLAQA--DSPVYSIVWAYDCDQLCYCTGSN---VVIKSLSSNAKQNAWKA 184 Query: 191 HTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCA 250 H G + V SP L +GG+D + +WD + + ++ ++P+ Sbjct: 185 HDGVVLKVDWSPINHLIITGGEDCKYKVWDSFGRLLFQSGLFDYPVTSVAWAPSGELFAV 244 Query: 251 ATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLF 299 ++++ D G S + +L+W+AD L Sbjct: 245 GGFNTLQLCDRMG---------WAYSKIHLNDTGSIMTLSWTADSTQLA 284 Score = 100 bits (249), Expect = 9e-22, Method: Composition-based stats. Identities = 38/210 (18%), Positives = 83/210 (39%), Gaps = 17/210 (8%) Query: 1 MTEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALR 60 ++ + +++GH G + + + +A D ++ +W G+ + L Sbjct: 90 LSRTGRVEKSIEGHKGACISLRWS-YDGTALATAGEDGSVKIWSRN------GMLRSTLA 142 Query: 61 GHSHFVSDVVISSDGQFAL--SGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNR 118 V +V + D +GS + + L++ + H VL V +S N Sbjct: 143 QADSPVYSIVWAYDCDQLCYCTGS---NVVIKSLSSNAKQNAWKAHDGVVLKVDWSPINH 199 Query: 119 QIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWN 178 I++G D K+W++ G + Q V+ V ++P S + G+ +++ + Sbjct: 200 LIITGGEDCKYKVWDSFG--RLLFQSGLFDYPVTSVAWAP--SGELFAVGGF-NTLQLCD 254 Query: 179 LANCKLKTNHIGHTGYLNTVTVSPDGSLCA 208 H+ TG + T++ + D + A Sbjct: 255 RMGWAYSKIHLNDTGSIMTLSWTADSTQLA 284 Score = 98.2 bits (243), Expect = 5e-21, Method: Composition-based stats. Identities = 44/215 (20%), Positives = 82/215 (38%), Gaps = 20/215 (9%) Query: 104 HTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNP 163 H++ +V ++ N + + S D+TI WN LG + V + + + + P SS Sbjct: 13 HSELTAAVGWNVWNE-LFTCSDDQTIHKWNMLGEPEQKVSTL--DAYFTDMHWYPVSSKK 69 Query: 164 -------IIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQA 216 + D VK+ + +++ + GH G ++ S DG+ A+ G+DG Sbjct: 70 TQAGGTDVFAVACTDGSVKILS-RTGRVEKSIEGHKGACISLRWSYDGTALATAGEDGSV 128 Query: 217 MLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVIS 276 +W N + ++ ++ + LC TG ++ I L Sbjct: 129 KIWSRNGMLRSTLAQADSPVYSIVWAYDCDQLCYCTGSNVVI---------KSLSSNAKQ 179 Query: 277 TSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQ 311 + KA + WS + G D +VW Sbjct: 180 NAWKAHDGVVLKVDWSPINHLIITGGEDCKYKVWD 214 Score = 35.1 bits (79), Expect = 0.037, Method: Composition-based stats. Identities = 17/106 (16%), Positives = 40/106 (37%), Gaps = 15/106 (14%) Query: 172 KLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNE-------- 223 V+ ++ A + HT + + +S G++ D Q ++ D N Sbjct: 439 TTVRFFDTAQGRPVGEPWQHTLEVKEIALSQAGTI-----NDRQLIVIDRNRDLYLLPVM 493 Query: 224 GKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDE 269 +H+ L + ++ + + L A + +W ++ VD+ Sbjct: 494 KRHVAKLAA--MCDSARWHDSTAMLSAMVDQRLCVWYYPSEVYVDK 537 >5WLC-SG nrPDB Length = 573 Score = 111 bits (277), Expect = 4e-25, Method: Composition-based stats. Identities = 57/317 (17%), Positives = 112/317 (35%), Gaps = 34/317 (10%) Query: 2 TEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRG 61 T + T +GH + +A +P +++ RD+ +I+W IP + RG Sbjct: 223 TSKHEYENTTEGHYDEILTVAASPD-GKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRRG 281 Query: 62 HSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIV 121 V + + + D +R + + + GH V ++ + R + Sbjct: 282 ---EVLSLAFRKNSDQLYASCADFKIRTYSINQFSQLEILYGHHDIVEDISALAMERCVT 338 Query: 122 SGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLAN 181 G+RD+T LW + T + + + R+ ++ G D VK + + Sbjct: 339 VGARDRTAMLWKIPDETRLTFRGGDEPQKLLR-RWMKENAKE-----GEDGEVKYPD-ES 391 Query: 182 CKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLD-GGDIINALC 240 G ++ V D +G +G LW L + K ++T I+ Sbjct: 392 EAPLFFCEGSIDVVSMV----DDFHFITGSDNGNICLWSLAKKKPIFTERIAHGILPEPS 447 Query: 241 FSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFA 300 F+ D+ G +EL++ + +P TSL + Sbjct: 448 FN-----------------DISG-ETDEELRKRQLQGKKLLQPFWITSLYAIPYSNVFIS 489 Query: 301 GYTDNLVRVWQVTIGTR 317 G ++VW+++ R Sbjct: 490 GSWSGSLKVWKISDNLR 506 Score = 54.7 bits (130), Expect = 5e-08, Method: Composition-based stats. Identities = 44/235 (18%), Positives = 77/235 (32%), Gaps = 47/235 (20%) Query: 4 QMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNY----------- 52 Q + L GH+ V I+ + +RD+T ++WK+ + Sbjct: 311 QFSQLEILYGHHDIVEDISALAME-RCVTVGARDRTAMLWKIPDETRLTFRGGDEPQKLL 369 Query: 53 --GIPQRALRGHSHFVS----------------DVVISSDGQFALSGSWDGTLRLWDLTT 94 + + A G V DVV D ++GS +G + LW L Sbjct: 370 RRWMKENAKEGEDGEVKYPDESEAPLFFCEGSIDVVSMVDDFHFITGSDNGNICLWSLAK 429 Query: 95 GTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCV 154 + +F+ +SG D+ ++ G W++ + Sbjct: 430 KKPIFTERIAHGILPEPSFND-----ISGETDEELRKRQLQGKKLLQPF------WITSL 478 Query: 155 RFSPNSSNPIIVSCGWDKLVKVW----NLANCKLKTNHIGHTGYLNTVTVSPDGS 205 P S + +S W +KVW NL + +L G G + + V G Sbjct: 479 YAIPYS--NVFISGSWSGSLKVWKISDNLRSFELLGELSGAKGVVTKIQVVESGK 531 >4J0X-A nrPDB Length = 451 Score = 110 bits (276), Expect = 6e-25, Method: Composition-based stats. Identities = 57/317 (17%), Positives = 112/317 (35%), Gaps = 34/317 (10%) Query: 2 TEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRG 61 T + T +GH + +A +P +++ RD+ +I+W IP + RG Sbjct: 101 TSKHEYENTTEGHYDEILTVAASPD-GKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRRG 159 Query: 62 HSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIV 121 V + + + D +R + + + GH V ++ + R + Sbjct: 160 ---EVLSLAFRKNSDQLYASCADFKIRTYSINQFSQLEILYGHHDIVEDISALAMERCVT 216 Query: 122 SGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLAN 181 G+RD+T LW + T + + + R+ ++ G D VK + + Sbjct: 217 VGARDRTAMLWKIPDETRLTFRGGDEPQKLLR-RWMKENAKE-----GEDGEVKYPD-ES 269 Query: 182 CKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLD-GGDIINALC 240 G ++ V D +G +G LW L + K ++T I+ Sbjct: 270 EAPLFFCEGSIDVVSMV----DDFHFITGSDNGNICLWSLAKKKPIFTERIAHGILPEPS 325 Query: 241 FSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFA 300 F+ D+ G +EL++ + +P TSL + Sbjct: 326 FN-----------------DISG-ETDEELRKRQLQGKKLLQPFWITSLYAIPYSNVFIS 367 Query: 301 GYTDNLVRVWQVTIGTR 317 G ++VW+++ R Sbjct: 368 GSWSGSLKVWKISDNLR 384 Score = 54.3 bits (129), Expect = 7e-08, Method: Composition-based stats. Identities = 44/235 (18%), Positives = 77/235 (32%), Gaps = 47/235 (20%) Query: 4 QMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNY----------- 52 Q + L GH+ V I+ + +RD+T ++WK+ + Sbjct: 189 QFSQLEILYGHHDIVEDISALAME-RCVTVGARDRTAMLWKIPDETRLTFRGGDEPQKLL 247 Query: 53 --GIPQRALRGHSHFVS----------------DVVISSDGQFALSGSWDGTLRLWDLTT 94 + + A G V DVV D ++GS +G + LW L Sbjct: 248 RRWMKENAKEGEDGEVKYPDESEAPLFFCEGSIDVVSMVDDFHFITGSDNGNICLWSLAK 307 Query: 95 GTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCV 154 + +F+ +SG D+ ++ G W++ + Sbjct: 308 KKPIFTERIAHGILPEPSFND-----ISGETDEELRKRQLQGKKLLQPF------WITSL 356 Query: 155 RFSPNSSNPIIVSCGWDKLVKVW----NLANCKLKTNHIGHTGYLNTVTVSPDGS 205 P S + +S W +KVW NL + +L G G + + V G Sbjct: 357 YAIPYS--NVFISGSWSGSLKVWKISDNLRSFELLGELSGAKGVVTKIQVVESGK 409 >3F3P-A nrPDB Length = 351 Score = 107 bits (267), Expect = 8e-24, Method: Composition-based stats. Identities = 63/342 (18%), Positives = 124/342 (36%), Gaps = 55/342 (16%) Query: 13 GHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVI- 71 GH+ V + + + + S D+ I ++KL +D +N+ + R H + + Sbjct: 9 GHDDLVHDVVYD-FYGRHVATCSSDQHIKVFKLDKDTSNWELSDS-WRAHDSSIVAIDWA 66 Query: 72 SSD-GQFALSGSWDGTLRLWDLTTG---------TTTRRFVGHTKDVLSVAFSS--DNRQ 119 S + G+ S S+D T++LW+ + SV F+ + Sbjct: 67 SPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLK 126 Query: 120 IVSGSRDKTIKLWNTLGVCKY------------TVQDESHSEWVSCVRFSPN--SSNPII 165 + D ++L++ L ++ +H + C+ + P+ S + Sbjct: 127 LACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLA 186 Query: 166 VSC---------GWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPD----GSLCASGGK 212 VS G D + V GH + +++ +P L A+G K Sbjct: 187 VSALEQAIIYQRGKDGKLHV--------AAKLPGHKSLIRSISWAPSIGRWYQLIATGCK 238 Query: 213 DGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWL-CAATGPSIKIWDLEGKIIVDELK 271 DG+ ++ + E L L + + N + A G S + E K + Sbjct: 239 DGRIRIFKITE--KLSPLASEESLTNSNMFDNSADVDMDAQGRSDS--NTEEKAELQSNL 294 Query: 272 QEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVT 313 Q + + + S++W+ G L + D VR+W+ T Sbjct: 295 QVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKAT 336 Score = 91.7 bits (226), Expect = 4e-19, Method: Composition-based stats. Identities = 48/308 (15%), Positives = 96/308 (31%), Gaps = 75/308 (24%) Query: 2 TEQMTLRGTLKGHNGWVTQIAT-TPQFPDMILSASRDKTIIMWKLTRDETNYGIPQR--- 57 T L + + H+ + I +P++ +I SAS DKT+ +W+ D+ + Sbjct: 44 TSNWELSDSWRAHDSSIVAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKL 103 Query: 58 -ALRGHSHFVSDVVISSD--GQFALSGSWDGTLRLWDLTTGTTTRRFV------------ 102 L + V + G DG LRL+D + R + Sbjct: 104 CTLNDSKGSLYSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPP 163 Query: 103 -GHTKDVLSVAFSSD----NRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFS 157 H + +++ + VS I G + H + + ++ Sbjct: 164 ANHLQSDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWA 223 Query: 158 PNSSN--PIIVSCGWDKLVKVWNLANC--------------------------------- 182 P+ +I + D ++++ + Sbjct: 224 PSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSN 283 Query: 183 -------------KLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDL---NEGKH 226 +L + H H G + +V+ + G++ +S G DG+ LW NE K Sbjct: 284 TEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKATYSNEFKC 343 Query: 227 LYTLDGGD 234 + + Sbjct: 344 MSVITAQQ 351 Score = 80.5 bits (197), Expect = 8e-16, Method: Composition-based stats. Identities = 46/247 (18%), Positives = 88/247 (35%), Gaps = 39/247 (15%) Query: 102 VGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNT---LGVCKYTVQDESHSEWVSCVRFSP 158 GH V V + R + + S D+ IK++ + + +H + + ++ Sbjct: 8 SGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWAS 67 Query: 159 NSSNPIIVSCGWDKLVKVWNLANCKL---------KTNHIGHTGYLNTVTVSPD--GSLC 207 II S +DK VK+W + G L +V +P G Sbjct: 68 PEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKL 127 Query: 208 ASGGKDGQAML-----------WDLNEGKHLYTLDGGDIINA---LCFSPNRYWLCAATG 253 A G DG L W L + ++ + + + L + P+R+ + Sbjct: 128 ACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRF-----SP 182 Query: 254 PSIKIWDLEGKIIVDELKQEVISTSSK--AEPPQCTSLAWSAD----GQTLFAGYTDNLV 307 + + LE II K + ++K S++W+ Q + G D + Sbjct: 183 EKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRI 242 Query: 308 RVWQVTI 314 R++++T Sbjct: 243 RIFKITE 249 Score = 29.3 bits (64), Expect = 2.0, Method: Composition-based stats. Identities = 4/37 (10%), Positives = 14/37 (37%) Query: 280 KAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGT 316 + + G+ + +D ++V+++ T Sbjct: 8 SGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDT 44 >3JZG-A nrPDB Length = 402 Score = 106 bits (265), Expect = 1e-23, Method: Composition-based stats. Identities = 54/272 (19%), Positives = 96/272 (35%), Gaps = 45/272 (16%) Query: 13 GHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVIS 72 GH + ++ P+ P+++LS S+D + +W + D + GH V Sbjct: 149 GHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDT--LVAIFGGVEGHRDEVLSADYD 206 Query: 73 SDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLW 132 G+ +S D +L+LW + + +R + K+ + NR +S + I Sbjct: 207 LLGEKIMSCGMDHSLKLWRINS----KRMMNAIKESYDYNPNKTNRPFIS----QKIHFP 258 Query: 133 NTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVW----------NLANC 182 + + H +V CVR+ +I+S + + W + Sbjct: 259 DFS-------TRDIHRNYVDCVRWL----GDLILSKSCENAIVCWKPGKMEDDIDKIKPS 307 Query: 183 KLKTNHIGHTGY----LNTVTVSPD--GSLCASGGKDGQAMLWDL----NEGKHLYTLDG 232 + +G Y + + S D + A G + G+ +WDL TL Sbjct: 308 ESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTH 367 Query: 233 GD---IINALCFSPNRYWLCA-ATGPSIKIWD 260 I FS + L A SI WD Sbjct: 368 HKCGAAIRQTSFSRDSSILIAVCDDASIWRWD 399 Score = 84.7 bits (208), Expect = 5e-17, Method: Composition-based stats. Identities = 57/304 (18%), Positives = 101/304 (33%), Gaps = 49/304 (16%) Query: 30 MILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISS-DGQFALSGSWDGTLR 88 ++ A I + + GH + ++++ D LS S D LR Sbjct: 123 LLAVAGSRGIIRI-----INPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALR 177 Query: 89 LWDLTTGTTTRRF---VGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDE 145 LW++ T T F GH +VLS + +I+S D ++KLW E Sbjct: 178 LWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKE 237 Query: 146 SHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGS 205 S ++PN +N +S + + + + + H Y++ V G Sbjct: 238 S-------YDYNPNKTNRPFIS----QKIHFPDFSTRDI------HRNYVDCVRWL--GD 278 Query: 206 LCASGGKDGQAMLWD-----------LNEGKHLYTLDGGD----IINALCFSPN---RYW 247 L S + + W ++ L D I + FS + + Sbjct: 279 LILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKML 338 Query: 248 LCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLV 307 + +WDLE + D K + + + ++S D L A D + Sbjct: 339 ALGNQVGKLYVWDLE---VEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASI 395 Query: 308 RVWQ 311 W Sbjct: 396 WRWD 399 Score = 70.1 bits (170), Expect = 1e-12, Method: Composition-based stats. Identities = 31/212 (14%), Positives = 78/212 (36%), Gaps = 17/212 (8%) Query: 93 TTGTTTRRFVG-HTKDVLSVAFSSDNR----QIVSGSRDKTIKLWNTLGVCKYTV----- 142 + H + + V F+ ++ + + + L+ + + Sbjct: 41 YSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYV 100 Query: 143 QDESHSEWVSCV-RFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVS 201 ++ + +C + N+S+P++ G ++++ N + +++GH +N + Sbjct: 101 DADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFH 160 Query: 202 P-DGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWL-----CAATGPS 255 P D +L S KD LW++ + G + S + L S Sbjct: 161 PRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHS 220 Query: 256 IKIWDLEGKIIVDELKQEVISTSSKAEPPQCT 287 +K+W + K +++ +K+ +K P + Sbjct: 221 LKLWRINSKRMMNAIKESYDYNPNKTNRPFIS 252 Score = 66.6 bits (161), Expect = 1e-11, Method: Composition-based stats. Identities = 23/186 (12%), Positives = 63/186 (33%), Gaps = 20/186 (10%) Query: 145 ESHSEWVSCVR--FSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGY-------- 194 E H++ + V+ + +P++ + V ++ + + Sbjct: 51 EDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYT 110 Query: 195 -LNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGG-DIINALCFSPNRY--WLCA 250 T + L A G G + + + + G + IN L F P L Sbjct: 111 CAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSV 170 Query: 251 ATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVW 310 + ++++W+++ +V + + S + G+ + + D+ +++W Sbjct: 171 SKDHALRLWNIQTDTLVAIF------GGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLW 224 Query: 311 QVTIGT 316 ++ Sbjct: 225 RINSKR 230 >5WLC-LN nrPDB Length = 776 Score = 105 bits (263), Expect = 2e-23, Method: Composition-based stats. Identities = 53/326 (16%), Positives = 104/326 (31%), Gaps = 36/326 (11%) Query: 15 NGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALR-----GHSHFVSDV 69 V +A D ++ D I +W +++ N G ++ S V V Sbjct: 187 EARVLTLAWKKD--DFVIGGCSDGRIRIWSAQKNDENMGRLLHTMKVDKAKKESTLVWSV 244 Query: 70 VISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTI 129 + SG G+++ WD T + F H DVL + +DN + S D+ I Sbjct: 245 IYLPRTDQIASGDSTGSIKFWDFQFATLNQSFKAHDADVLCLTTDTDNNYVFSAGVDRKI 304 Query: 130 KLW-------NTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANC 182 + + H + + + +VS G +K + + +L + Sbjct: 305 FQFSQNTNKSQKNNRWVNSSNRLLHGNDIRAICAYQSKGADFLVSGGVEKTLVINSLTSF 364 Query: 183 K--LKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGK---------HLYTLD 231 Y V V+ + L S + +W + TL Sbjct: 365 SNGNYRKMPTVEPYSKNVLVNKEQRLVVSWSE-STVKIWTMGTDSSTEQNYKLVCKLTLK 423 Query: 232 GGDIINALCFSPNRYWLCAATGPSIKIWDLE---GKIIVDELKQEVISTSSKAEPPQCTS 288 I+ SP+ L + K++ L+ K+ V +L +++ +S Sbjct: 424 DDQNISTCSLSPDGQVLVVGRPSTTKVFHLQPVGNKLKVTKLDNDLLLRTSTKLVKFI-- 481 Query: 289 LAWSADGQTLFAGYTDNLVRVWQVTI 314 D + ++ V + + Sbjct: 482 -----DNSKIVICSCEDDVFIVDLES 502 Score = 79.7 bits (195), Expect = 1e-15, Method: Composition-based stats. Identities = 45/320 (14%), Positives = 97/320 (30%), Gaps = 35/320 (10%) Query: 16 GWVTQIATTPQFPDMILSASR--------DKTIIMWKLTRDETNYGIPQRALRGHSHFVS 67 +T +A + + L+ S + I +W N+ G + Sbjct: 44 ATITSLAFSHKSNINKLTPSDLRLAIGRSNGNIEIWNPRN---NWFQEMVIEGGKDRSIE 100 Query: 68 DVVISS---DGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGS 124 + S+ + S + WDL TG R + ++ + S++ + ++ G Sbjct: 101 GLCWSNVNGESLRLFSIGGSTVVTEWDLATGLPLRNYDCNSGVIWSISINDSQDKLSVGC 160 Query: 125 RDKTIKLWNTLGVCKYTVQDE---SHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLAN 181 + T+ L + G D V + + + ++ D +++W+ Sbjct: 161 DNGTVVLIDISGGPGVLEHDTILMRQEARVLTLAWKKDD---FVIGGCSDGRIRIWSAQK 217 Query: 182 CKLKTNHIGHTGY----------LNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLD 231 + HT + +V P ASG G WD + Sbjct: 218 NDENMGRLLHTMKVDKAKKESTLVWSVIYLPRTDQIASGDSTGSIKFWDFQFATLNQSFK 277 Query: 232 GG--DIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSL 289 D++ + N Y A I + + + + V S++ ++ Sbjct: 278 AHDADVLCLTTDTDNNYVFSAGVDRKIFQFS-QNTNKSQKNNRWVNSSNRLLHGNDIRAI 336 Query: 290 AW--SADGQTLFAGYTDNLV 307 S L +G + + Sbjct: 337 CAYQSKGADFLVSGGVEKTL 356 Score = 72.8 bits (177), Expect = 2e-13, Method: Composition-based stats. Identities = 38/240 (15%), Positives = 89/240 (37%), Gaps = 10/240 (4%) Query: 85 GTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVC-KYTVQ 143 R D T T T H ++ + + ++ G + I++WN + V Sbjct: 34 HRCRFVDFTPATITSLAFSHKSNIN--KLTPSDLRLAIGRSNGNIEIWNPRNNWFQEMVI 91 Query: 144 DESHSEWVSCVRFSP-NSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSP 202 + + + +S N + + S G +V W+LA N+ ++G + +++++ Sbjct: 92 EGGKDRSIEGLCWSNVNGESLRLFSIGGSTVVTEWDLATGLPLRNYDCNSGVIWSISIND 151 Query: 203 DGSLCASGGKDGQAMLWDLNEGKHLYTLDG-----GDIINALCFSPNRYWLCAATGPSIK 257 + G +G +L D++ G + D + L + + + + + I+ Sbjct: 152 SQDKLSVGCDNGTVVLIDISGGPGVLEHDTILMRQEARVLTLAWKKDDFVIGGCSDGRIR 211 Query: 258 IWDLE-GKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGT 316 IW + + L + +K E S+ + + +G + ++ W T Sbjct: 212 IWSAQKNDENMGRLLHTMKVDKAKKESTLVWSVIYLPRTDQIASGDSTGSIKFWDFQFAT 271 >5K19-A nrPDB Length = 569 Score = 105 bits (263), Expect = 2e-23, Method: Composition-based stats. Identities = 53/275 (19%), Positives = 93/275 (33%), Gaps = 44/275 (16%) Query: 18 VTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRAL--RGHSHFV--------- 66 VT + P + L A + ++ + P L +G S V Sbjct: 152 VTCVKWVPGSESLFLVAHSSGNMYLYNV-EHTCGTTAPHYQLLKQGESFAVHTCKSKSTR 210 Query: 67 -------------SDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAF 113 ++ S DG+F S DG LR+++ + + +L V + Sbjct: 211 NPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCW 270 Query: 114 SSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSS-----NPIIVSC 168 S D + IV+G D + +W+ + C+ + H WVS V F P ++ +P+ S Sbjct: 271 SPDGKYIVTGGEDDLVTVWSFVD-CRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSG 329 Query: 169 GWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSL--CASGGKDGQAMLWDLNE--- 223 + + + + + N+ P S G+D Q LWDL E Sbjct: 330 SDEDFQDLLHFGRDRANSTQ-SRLSKRNSTDSRPVSVTYRFGSVGQDTQLCLWDLTEDIL 388 Query: 224 --GKHLYTLDGGDIINALCFSPNRYWLCAATGPSI 256 + L + P + G S+ Sbjct: 389 FPHQPLSRARTHTNVMNATSPP-----AGSNGNSV 418 Score = 58.9 bits (141), Expect = 3e-09, Method: Composition-based stats. Identities = 36/227 (15%), Positives = 84/227 (37%), Gaps = 30/227 (13%) Query: 91 DLTTGTTTRRFVGH---TKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESH 147 DL+ R + G D + ++++ ++ G ++L + + + +E Sbjct: 86 DLSKPIDKRIYKGTQPTCHDFNHLTATAESVSLLVGFSAGQVQLIDPIKKETSKLFNEER 145 Query: 148 ---SEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDG 204 V+CV++ P S + +V+ + ++N+ + H L Sbjct: 146 LIDKSRVTCVKWVPGSESLFLVAHSS-GNMYLYNVEH--TCGTTAPHYQLLKQGESFAVH 202 Query: 205 SLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAAT-GPSIKIWDLEG 263 + + ++ W + EG +N FSP+ +L + +++++ + Sbjct: 203 TCKSKSTRNPLLK-WTVGEGA----------LNEFAFSPDGKFLACVSQDGFLRVFNFDS 251 Query: 264 KIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVW 310 + + K+ + WS DG+ + G D+LV VW Sbjct: 252 VEL---------HGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVW 289 Score = 47.8 bits (112), Expect = 6e-06, Method: Composition-based stats. Identities = 27/180 (15%), Positives = 56/180 (31%), Gaps = 18/180 (10%) Query: 3 EQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGH 62 + + L GT+K + G + + +P I++ D + +W GH Sbjct: 250 DSVELHGTMKSYFGGLLCVCWSPD-GKYIVTGGEDDLVTVWSFVD-----CRVIARGHGH 303 Query: 63 SHFVSDVVISSDGQFA-------LSGSW-DGTLRLWDLTTGTTTRRFVGHTKDVLSVAFS 114 +VS V SGS D L + + ++ Sbjct: 304 KSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFGRDRANSTQSRLSKRNSTDSRPV 363 Query: 115 SDNRQIVSGSRDKTIKLWNTLG----VCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGW 170 S + S +D + LW+ + + +H+ ++ S+ + + G Sbjct: 364 SVTYRFGSVGQDTQLCLWDLTEDILFPHQPLSRARTHTNVMNATSPPAGSNGNSVTTPGN 423 Score = 33.1 bits (74), Expect = 0.16, Method: Composition-based stats. Identities = 21/145 (14%), Positives = 45/145 (31%), Gaps = 26/145 (17%) Query: 196 NTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLD-----GGDIINALCFSP--NRYWL 248 N +T + + G GQ L D + + + + + + P +L Sbjct: 107 NHLTATAESVSLLVGFSAGQVQLIDPIKKETSKLFNEERLIDKSRVTCVKWVPGSESLFL 166 Query: 249 CAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTS-------------------L 289 A + ++ ++++E +++ C S Sbjct: 167 VAHSSGNMYLYNVEHTCGTTAPHYQLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEF 226 Query: 290 AWSADGQTLFAGYTDNLVRVWQVTI 314 A+S DG+ L D +RV+ Sbjct: 227 AFSPDGKFLACVSQDGFLRVFNFDS 251 >3ACP-A nrPDB Length = 417 Score = 105 bits (261), Expect = 3e-23, Method: Composition-based stats. Identities = 51/233 (21%), Positives = 91/233 (39%), Gaps = 34/233 (14%) Query: 12 KGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVI 71 + H +T++ P + ++S+S+D + +W + G R L GH V+D+ I Sbjct: 133 QAHVSEITKLKFFPS-GEALISSSQDMQLKIWSV-----KDGSNPRTLIGHRATVTDIAI 186 Query: 72 SSDGQFALSGSWDGTLRLWDLTTGTTTRRF---VGHTKDVLSVA---------------- 112 G+ LS S DGT+RLW+ TGTT F V S+A Sbjct: 187 IDRGRNVLSASLDGTIRLWECGTGTTIHTFNRKENPHDGVNSIALFVGTDRQLHEISTSK 246 Query: 113 -----FSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVS 167 F + + +++G I + N + + + + N++N I + Sbjct: 247 KNNLEFGTYGKYVIAGHVSGVITVHNVFSKEQTIQLPSKFTCSCNSLTVDGNNAN-YIYA 305 Query: 168 CGWDKLVKVWNLANCKLK--TNHIGHTGYLNTVTVSPDGSLCASGGKDGQAML 218 + ++ W+L + + I +N V + G+L S G D L Sbjct: 306 GYENGMLAQWDLRSPECPVGEFLINEGTPINNVYFAA-GALFVSSGFDTSIKL 357 Score = 100 bits (248), Expect = 1e-21, Method: Composition-based stats. Identities = 51/300 (17%), Positives = 113/300 (37%), Gaps = 29/300 (9%) Query: 44 KLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVG 103 + ++N+ + + + H ++ + G+ +S S D L++W + G+ R +G Sbjct: 117 DIKVLDSNFNLQREIDQAHVSEITKLKFFPSGEALISSSQDMQLKIWSVKDGSNPRTLIG 176 Query: 104 HTKDVLSVAFSSDNRQIVSGSRDKTIKLWN--TLGVCKYTVQDESHSEWVSCVRFSPNSS 161 H V +A R ++S S D TI+LW T + E+ + V+ + + Sbjct: 177 HRATVTDIAIIDRGRNVLSASLDGTIRLWECGTGTTIHTFNRKENPHDGVNSIALFVGTD 236 Query: 162 -------------------NPIIVSCGWDKLVKVWNLANCKLKTNHIGH-TGYLNTVTVS 201 +++ ++ V N+ + + T N++TV Sbjct: 237 RQLHEISTSKKNNLEFGTYGKYVIAGHVSGVITVHNVFSKEQTIQLPSKFTCSCNSLTVD 296 Query: 202 -PDGSLCASGGKDGQAMLWDLNEGKH---LYTLDGGDIINALCFSPNRYWLCAATGPSIK 257 + + +G ++G WDL + + ++ G IN + F+ ++ + SIK Sbjct: 297 GNNANYIYAGYENGMLAQWDLRSPECPVGEFLINEGTPINNVYFAAGALFVSSGFDTSIK 356 Query: 258 ---IWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTI 314 I D E + E + S+ E Q ++ + +N ++ ++ Sbjct: 357 LDIISDPESERPAIEFETPTFLVSNDDEVSQFCYVSDDESNGEVLEVGKNNFCALYNLSN 416 Score = 71.3 bits (173), Expect = 6e-13, Method: Composition-based stats. Identities = 33/243 (13%), Positives = 76/243 (31%), Gaps = 34/243 (13%) Query: 76 QFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTL 135 + + G+ +G +++ D H ++ + F ++S S+D +K+W+ Sbjct: 107 RRFILGTTEGDIKVLDSNFNLQREIDQAHVSEITKLKFFPSGEALISSSQDMQLKIWSVK 166 Query: 136 GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGY- 194 H V+ + N ++S D +++W Sbjct: 167 DGSNPR-TLIGHRATVTDIAIIDRGRN--VLSASLDGTIRLWECGTGTTIHTFNRKENPH 223 Query: 195 --LNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAAT 252 +N++ + G D Q +++ K N L F ++ A Sbjct: 224 DGVNSIAL--------FVGTDRQLH--EISTSKK----------NNLEFGTYGKYVIAGH 263 Query: 253 GPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADG-QTLFAGYTDNLVRVWQ 311 + + + +E C SL + ++AGY + ++ W Sbjct: 264 VSGV-------ITVHNVFSKEQTIQLPSKFTCSCNSLTVDGNNANYIYAGYENGMLAQWD 316 Query: 312 VTI 314 + Sbjct: 317 LRS 319 Score = 62.4 bits (150), Expect = 2e-10, Method: Composition-based stats. Identities = 30/223 (13%), Positives = 71/223 (31%), Gaps = 21/223 (9%) Query: 112 AFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWD 171 F + D L+NT+ + + V + + + Sbjct: 60 TFEKVGSHLYKARLDGHDFLFNTIIRDGSKMLKRADYTAVDTAKLQM----RRFILGTTE 115 Query: 172 KLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLD 231 +KV + + H + + P G S +D Q +W + +G + TL Sbjct: 116 GDIKVLDSNFNLQREIDQAHVSEITKLKFFPSGEALISSSQDMQLKIWSVKDGSNPRTLI 175 Query: 232 GG-DIINALCFSP-NRYWLCAATGPSIKIWDLEGKIIVDELKQE----------VISTSS 279 G + + R L A+ +I++W+ + ++ + + Sbjct: 176 GHRATVTDIAIIDRGRNVLSASLDGTIRLWECGTGTTIHTFNRKENPHDGVNSIALFVGT 235 Query: 280 KAEPPQCTS-----LAWSADGQTLFAGYTDNLVRVWQVTIGTR 317 + + ++ L + G+ + AG+ ++ V V + Sbjct: 236 DRQLHEISTSKKNNLEFGTYGKYVIAGHVSGVITVHNVFSKEQ 278 >5CXC-A nrPDB Length = 510 Score = 103 bits (257), Expect = 8e-23, Method: Composition-based stats. Identities = 56/302 (18%), Positives = 95/302 (31%), Gaps = 41/302 (13%) Query: 29 DMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLR 88 + +LSAS D + +W P + GH+ + + + S D T+R Sbjct: 159 ERVLSASYDGLLRIWNA-SGSVIATSPSGSHGGHTASIKAAKFLTSDR-LASAGMDRTVR 216 Query: 89 LW-----DLTTGTTTRRFV--GHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYT 141 +W D TG GHT V + ++ I++ S D I W+ Sbjct: 217 VWKYTESDHFTGELKPTLELYGHTGSVDWLDVDGHSKHILTASADGAIGFWSASKASAP- 275 Query: 142 VQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVS 201 E + + S VS + +W++ HT Sbjct: 276 ---EPDASLLPGAHVSKRRKATSSVSTAQRGPLGLWSI-----------HTAPATAAIFD 321 Query: 202 PDGSLCA-SGGKDGQAMLWDLNEGKHLYTLDGGDIINALCF-------SPNRYWLCAATG 253 P A S +D DL G+ + TL + +L SP + Sbjct: 322 PRDRTVAYSASQDHTVRTLDLTTGQVVSTLTLTHPLLSLSALTRAGTTSP--LLAAGTSA 379 Query: 254 PSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQT-LFAGYTDNLVRVWQV 312 I + D + + + + SL+ S + + L +G D RVW + Sbjct: 380 RHITMVDPRASSATTSV------MTLRGHANKVVSLSPSPENEYSLVSGSHDGTCRVWDL 433 Query: 313 TI 314 Sbjct: 434 RS 435 Score = 100 bits (248), Expect = 1e-21, Method: Composition-based stats. Identities = 57/334 (17%), Positives = 113/334 (33%), Gaps = 61/334 (18%) Query: 13 GHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYG--IPQRALRGHSHFVSDVV 70 GH + D + SA D+T+ +WK T + G P L GH+ V + Sbjct: 190 GHTASIKAAKFL--TSDRLASAGMDRTVRVWKYTESDHFTGELKPTLELYGHTGSVDWLD 247 Query: 71 ISSDGQFALSGSWDGTLRLWDLT-----------------------TGTTTRRFVG---- 103 + + L+ S DG + W + T + + G Sbjct: 248 VDGHSKHILTASADGAIGFWSASKASAPEPDASLLPGAHVSKRRKATSSVSTAQRGPLGL 307 Query: 104 ---HTKDVLSVAFSSDNRQIV-SGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPN 159 HT + F +R + S S+D T++ + + +H Sbjct: 308 WSIHTAPATAAIFDPRDRTVAYSASQDHTVRTLDLTTGQVVSTLTLTHPLLSLSALTRAG 367 Query: 160 SSNPIIVSCGWDKLVKVWNLANCKL---KTNHIGHTGYLNTVTVSP-DGSLCASGGKDGQ 215 +++P++ + + + + + GH + +++ SP + SG DG Sbjct: 368 TTSPLLAAGTSARHITMVDPRASSATTSVMTLRGHANKVVSLSPSPENEYSLVSGSHDGT 427 Query: 216 AMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVI 275 +WDL + +G L + P ++ +E + + K++ Sbjct: 428 CRVWDLRSVRPATKEEGS--------------LGGVSEP---VYVIERESWASKGKKKR- 469 Query: 276 STSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRV 309 + + S+ W G +F+G D V+V Sbjct: 470 --PVAGDGCKVFSVVWDKLG--IFSGGEDKKVQV 499 Score = 75.9 bits (185), Expect = 2e-14, Method: Composition-based stats. Identities = 46/228 (20%), Positives = 81/228 (35%), Gaps = 37/228 (16%) Query: 2 TEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWK----------------- 44 T ++ L GH G V + ++ +AS D I W Sbjct: 227 TGELKPTLELYGHTGSVDWLDVDGHSKHIL-TASADGAIGFWSASKASAPEPDASLLPGA 285 Query: 45 -LTRDETNYGIPQRALRG-------HSHFVSDVVISSDGQFAL-SGSWDGTLRLWDLTTG 95 +++ A RG H+ + + + S S D T+R DLTTG Sbjct: 286 HVSKRRKATSSVSTAQRGPLGLWSIHTAPATAAIFDPRDRTVAYSASQDHTVRTLDLTTG 345 Query: 96 TTTRRFVGHTKDVLSVA----FSSDNRQIVSGSRDKTIKLWNTLGVCKYT--VQDESHSE 149 T +LS++ + + + +G+ + I + + T + H+ Sbjct: 346 QVVSTLTL-THPLLSLSALTRAGTTSPLLAAGTSARHITMVDPRASSATTSVMTLRGHAN 404 Query: 150 WVSCVRFSPNSSNPI-IVSCGWDKLVKVWNLANCKLKTNHIGHTGYLN 196 V V SP+ N +VS D +VW+L + + T G G ++ Sbjct: 405 KV--VSLSPSPENEYSLVSGSHDGTCRVWDLRSVRPATKEEGSLGGVS 450 Score = 55.5 bits (132), Expect = 3e-08, Method: Composition-based stats. Identities = 30/126 (23%), Positives = 46/126 (36%), Gaps = 20/126 (15%) Query: 6 TLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHF 65 T TL+GH V ++ +P+ ++S S D T +W L + +L G S Sbjct: 394 TSVMTLRGHANKVVSLSPSPENEYSLVSGSHDGTCRVWDLRSVRPAT-KEEGSLGGVSEP 452 Query: 66 VSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSR 125 V + S W + G R G V SV + I SG Sbjct: 453 VYVIERES----------------W-ASKGKKKRPVAGDGCKVFSVVWDKLG--IFSGGE 493 Query: 126 DKTIKL 131 DK +++ Sbjct: 494 DKKVQV 499 Score = 50.8 bits (120), Expect = 8e-07, Method: Composition-based stats. Identities = 28/193 (14%), Positives = 52/193 (26%), Gaps = 35/193 (18%) Query: 155 RFSPNSSNPIIVS--CGWDKLVKVWNLANCKLKTN--HIGHTGYLNTVTV----SPDGSL 206 F +S + S + + + + + H +++ V V SP G Sbjct: 85 SFLRSSLEDYLTSNGLSLETTLTLQYVRSLIPPVYEASFEHDDWVSAVDVLSATSPAGRW 144 Query: 207 ----------------CASGGKDGQAMLWDLNEGKHLYTLDGGD------IINALCFSPN 244 S DG +W+ G + T G I A F + Sbjct: 145 SSAANSSAAVQPGQERVLSASYDGLLRIWN-ASGSVIATSPSGSHGGHTASIKAAKFLTS 203 Query: 245 RYWLCAATGPSIKIWDL-EGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYT 303 A ++++W E ELK + L + + Sbjct: 204 DRLASAGMDRTVRVWKYTESDHFTGELKP---TLELYGHTGSVDWLDVDGHSKHILTASA 260 Query: 304 DNLVRVWQVTIGT 316 D + W + + Sbjct: 261 DGAIGFWSASKAS 273 >5BJS-A nrPDB Length = 605 Score = 100 bits (249), Expect = 8e-22, Method: Composition-based stats. Identities = 43/148 (29%), Positives = 58/148 (39%), Gaps = 17/148 (11%) Query: 6 TLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRD-ETNYGIPQRALRGHSH 64 L TL GH G + +AT+P P +I SAS D TI +W L + E + GHS+ Sbjct: 169 KLYRTLVGHGGGINDLATSPANPYIIASASDDTTIRIWSLAPEHEKQPCVCILGGEGHSY 228 Query: 65 FVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTR-------------RFVGHTKDVLSV 111 + V +G++ LS D + LW L H V V Sbjct: 229 DLLSVAFHDNGRYVLSAGHDQVINLWALPEFPNEHMEIPIVIYYPHFSSSEIHNNLVDCV 288 Query: 112 AFSSDNRQIVS-GSRDKTIKLWNTLGVC 138 AF I+S + TI LW G Sbjct: 289 AF--YGDLILSRACHEDTIVLWRIEGFS 314 Score = 86.7 bits (213), Expect = 1e-17, Method: Composition-based stats. Identities = 41/195 (21%), Positives = 74/195 (37%), Gaps = 19/195 (9%) Query: 136 GVCKYTVQDESHSEWVSCVRF---SPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHT 192 C+ +C P + P++ G + VKV+N+ KL +GH Sbjct: 119 NPCEIIQLIRDDGNEANCASCWSKDPITDQPLLCIAGNEGNVKVYNVTEGKLYRTLVGHG 178 Query: 193 GYLNTVTVSP-DGSLCASGGKDGQAMLWDLN---EGKHLYTLDGGD----IINALCFSPN 244 G +N + SP + + AS D +W L E + + GG+ + ++ F N Sbjct: 179 GGINDLATSPANPYIIASASDDTTIRIWSLAPEHEKQPCVCILGGEGHSYDLLSVAFHDN 238 Query: 245 -RYWLCAATGPSIKIWDLEGKIIVDELKQEVIS----TSSKAEPPQCTSLAWSADGQTLF 299 RY L A I +W L VI +SS+ +A+ G + Sbjct: 239 GRYVLSAGHDQVINLWALPEFPNEHMEIPIVIYYPHFSSSEIHNNLVDCVAF--YGDLIL 296 Query: 300 A-GYTDNLVRVWQVT 313 + ++ + +W++ Sbjct: 297 SRACHEDTIVLWRIE 311 Score = 82.4 bits (202), Expect = 2e-16, Method: Composition-based stats. Identities = 48/277 (17%), Positives = 96/277 (34%), Gaps = 43/277 (15%) Query: 25 PQFPDMILSASRDKTI--IMWKLTRDETNYGIPQRALRGHSHFVSDV-VIS----SDGQF 77 P P + + S+ + + + T + N + +R + + S +D Sbjct: 91 PGAPPVFAATSKKHAVICRLTQTTDKDANPCEIIQLIRDDGNEANCASCWSKDPITDQPL 150 Query: 78 ALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIV-SGSRDKTIKLWNT-- 134 +G ++++++T G R VGH + +A S N I+ S S D TI++W+ Sbjct: 151 LCIAGNEGNVKVYNVTEGKLYRTLVGHGGGINDLATSPANPYIIASASDDTTIRIWSLAP 210 Query: 135 ---LGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGH 191 C + E HS + V F N ++S G D+++ +W L Sbjct: 211 EHEKQPCVCILGGEGHSYDLLSVAFHDNGR--YVLSAGHDQVINLWALPE------FPNE 262 Query: 192 TGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAA 251 + V P + ++++ + F + A Sbjct: 263 HMEIPIVIYYPH----------------------FSSSEIHNNLVDCVAFYGDLILSRAC 300 Query: 252 TGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTS 288 +I +W +EG D + + + + Q S Sbjct: 301 HEDTIVLWRIEGFSSDDPIPGPLDAPTPTDMTKQTRS 337 >6E29-D nrPDB Length = 345 Score = 100 bits (248), Expect = 1e-21, Method: Composition-based stats. Identities = 51/285 (17%), Positives = 99/285 (34%), Gaps = 34/285 (11%) Query: 61 GHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQI 120 GHS + V + G F SG DGT+ +WDL T R+ GH+K++ S+++S R + Sbjct: 26 GHS---TCVRFNRKGDFLASGRVDGTVVIWDLETMGVARKLRGHSKNITSLSWSRCGRYL 82 Query: 121 VSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVW--- 177 +S + + LW+ +Y V P + + + D+ + V Sbjct: 83 LSACQGWKVILWDLQDGKRYREVRF--RAPVYGAELHPWNHHQFAAALFEDQPMLVDITE 140 Query: 178 ---------------NLANCKLKTNHIGHTGYLN---TVTVSPDGSLCASGGKDGQAMLW 219 + + + + G +G G+ + Sbjct: 141 PVEVRYVLPSVPKRTSTETDPALREKQAKEDAKHMTTAIVYTASGDHLLAGTTKGRLNII 200 Query: 220 DLNEGKHLYTLD-GGDIINALCFSPN-RYWLCAATGPSIKIWDLEGKIIVDELKQEVIST 277 D + +Y+ II L + + R L A I+ + + D + Sbjct: 201 DARTREIIYSEKIASGIITTLRLTESGRELLVNAQDRIIRTFIVPNLSAADLDPDTIQLP 260 Query: 278 SSKAEPPQCTSL-----AWSADGQTL-FAGYTDNLVRVWQVTIGT 316 L A+SA G+ + + Y ++ + +W+ G+ Sbjct: 261 LEHKFQDVVNRLSWNHVAFSATGEYVAASTYNNHELYIWERGHGS 305 Score = 87.1 bits (214), Expect = 1e-17, Method: Composition-based stats. Identities = 55/339 (16%), Positives = 110/339 (32%), Gaps = 57/339 (16%) Query: 13 GHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVIS 72 GH+ T + + D + S D T+++W L R LRGHS ++ + S Sbjct: 26 GHS---TCVRFNRK-GDFLASGRVDGTVVIWDL-----ETMGVARKLRGHSKNITSLSWS 76 Query: 73 SDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSS-DNRQIVSGSRDKTIKL 131 G++ LS + LWDL G R V ++ Q + + L Sbjct: 77 RCGRYLLSACQGWKVILWDLQDGKRYREVRFR-APVYGAELHPWNHHQFAAALFEDQPML 135 Query: 132 WNTL-----GVCKYTVQDESHSEWVSCVR------FSPNSSNPIIVSCGWD--------K 172 + +V + +E +R + + + I+ + D Sbjct: 136 VDITEPVEVRYVLPSVPKRTSTETDPALREKQAKEDAKHMTTAIVYTASGDHLLAGTTKG 195 Query: 173 LVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLW--------DLNEG 224 + + + ++ + +G + T+ ++ G +D + DL+ Sbjct: 196 RLNIIDARTREIIYSEKIASGIITTLRLTESGRELLVNAQDRIIRTFIVPNLSAADLDPD 255 Query: 225 KHLYTLDGGD-------IINALCFSPNRYWLCAATGPS--IKIWDLEGKIIVDELKQEVI 275 L+ N + FS ++ A+T + + IW+ +V L+ Sbjct: 256 TIQLPLEHKFQDVVNRLSWNHVAFSATGEYVAASTYNNHELYIWERGHGSLVRMLEGPKE 315 Query: 276 STSSKAEPPQCTSLAWSADGQTLFAGYTD-NLVRVWQVT 313 + W L A + + +W VT Sbjct: 316 EQGV---------IEWHPHRALLAACGLETGRINIWSVT 345 Score = 63.2 bits (152), Expect = 1e-10, Method: Composition-based stats. Identities = 41/301 (13%), Positives = 103/301 (34%), Gaps = 51/301 (16%) Query: 2 TEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRG 61 E M + L+GH+ +T ++ + + +LSA + +I+W L + + RA Sbjct: 54 LETMGVARKLRGHSKNITSLSWS-RCGRYLLSACQGWKVILWDLQDGKRYREVRFRA--- 109 Query: 62 HSHFVSDVVISS-DGQFALSGSWDGTLRLWDLTTGTTTRRF-------VGHTKDV----- 108 V + + + ++ L D+T R D Sbjct: 110 ---PVYGAELHPWNHHQFAAALFEDQPMLVDITEPVEVRYVLPSVPKRTSTETDPALREK 166 Query: 109 ----------LSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSP 158 ++ +++ +++G+ + + + + ++ S ++ +R + Sbjct: 167 QAKEDAKHMTTAIVYTASGDHLLAGTTKGRLNIIDAR-TREIIYSEKIASGIITTLRLTE 225 Query: 159 NSSNPIIVSCGWDKLVKVW--------NLANCKLKTNHIGHTGYL------NTVTVSPDG 204 + ++ D++++ + +L ++ + N V S G Sbjct: 226 SGRELLV--NAQDRIIRTFIVPNLSAADLDPDTIQLPLEHKFQDVVNRLSWNHVAFSATG 283 Query: 205 SLCASGGKDGQ-AMLWDLNEGKHLYTLDGGDIINALC-FSPNRYWLCAATGPS--IKIWD 260 A+ + +W+ G + L+G + + P+R L A + I IW Sbjct: 284 EYVAASTYNNHELYIWERGHGSLVRMLEGPKEEQGVIEWHPHRALLAACGLETGRINIWS 343 Query: 261 L 261 + Sbjct: 344 V 344 Score = 57.0 bits (136), Expect = 1e-08, Method: Composition-based stats. Identities = 30/118 (25%), Positives = 46/118 (38%), Gaps = 7/118 (5%) Query: 169 GWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLY 228 D L++ + T GH+ V + G ASG DG ++WDL Sbjct: 7 SDDYLLQ--DYPENITNTIRSGHS---TCVRFNRKGDFLASGRVDGTVVIWDLETMGVAR 61 Query: 229 TLDGGDI-INALCFSP-NRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPP 284 L G I +L +S RY L A G + +WDL+ E++ ++ P Sbjct: 62 KLRGHSKNITSLSWSRCGRYLLSACQGWKVILWDLQDGKRYREVRFRAPVYGAELHPW 119 Score = 52.0 bits (123), Expect = 3e-07, Method: Composition-based stats. Identities = 22/99 (22%), Positives = 36/99 (36%), Gaps = 12/99 (12%) Query: 220 DLNEGKHLYTLDGGDIINALCFSPNRYWLCAAT-GPSIKIWDLEGKIIVDELKQEVISTS 278 D E G + F+ +L + ++ IWDLE + +L+ Sbjct: 14 DYPENITNTIRSGHS--TCVRFNRKGDFLASGRVDGTVVIWDLETMGVARKLR------- 64 Query: 279 SKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGTR 317 TSL+WS G+ L + V +W + G R Sbjct: 65 --GHSKNITSLSWSRCGRYLLSACQGWKVILWDLQDGKR 101 Score = 38.5 bits (88), Expect = 0.004, Method: Composition-based stats. Identities = 9/54 (16%), Positives = 21/54 (38%), Gaps = 3/54 (5%) Query: 261 LEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTI 314 L ++ + + + +T T + ++ G L +G D V +W + Sbjct: 6 LSDDYLLQDYPENITNTIRSGHS---TCVRFNRKGDFLASGRVDGTVVIWDLET 56 >4E5Z-B nrPDB Length = 436 Score = 99.8 bits (247), Expect = 1e-21, Method: Composition-based stats. Identities = 60/320 (18%), Positives = 113/320 (35%), Gaps = 30/320 (9%) Query: 19 TQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISS-DGQF 77 T +A P P + S+ I++W + I G ++ + + + Sbjct: 123 TSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGI---GAGGSITGLKFNPLNTNQ 179 Query: 78 ALSGSWDGTLRLWDLTTGTTTRRFVGHTK---DVLSVAFSSDNRQIVSGSRDKTIKLWNT 134 + S +GT RL D G R F S+ S+ +R +V+G + L N Sbjct: 180 FYASSMEGTTRLQDFK-GNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNM 238 Query: 135 LGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNH---IGH 191 G + ++ H + V+ V +P + + D+ VK+W+L + K + + H Sbjct: 239 DGKELWNLRM--HKKKVTHVALNPCCD-WFLATASVDQTVKIWDLRQVRGKASFLYSLPH 295 Query: 192 TGYLNTVTVSPDGSLCASGGKDGQAML-----WDLNEG---KHLYTLDGGDIINALCFSP 243 +N SPDG+ + + + + WD G I A + P Sbjct: 296 RHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKA-AWHP 354 Query: 244 NRYWLCAATGP-----SIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLA-WSADGQT 297 + P S ++L + D +++ E +SL ++ G T Sbjct: 355 RYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDT 414 Query: 298 LFAGYTDNLVRVWQVTIGTR 317 L + + +W R Sbjct: 415 LASAMG-YHILIWSEQEEAR 433 Score = 67.8 bits (164), Expect = 6e-12, Method: Composition-based stats. Identities = 34/223 (15%), Positives = 66/223 (29%), Gaps = 44/223 (19%) Query: 9 GTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSD 68 L+ H VT +A P + +AS D+T+ +W L + H H V+ Sbjct: 244 WNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLP--HRHPVNA 301 Query: 69 VVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSV------AFSSDNRQIVS 122 S DG L+ +R++ + + H A+ IV Sbjct: 302 ACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVV 361 Query: 123 GSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANC 182 G + + E + + V++ + Sbjct: 362 G------------RYPDPNFKSCTPYEL---------------------RTIDVFDGNSG 388 Query: 183 KLKTNHI-GHTGYLNTV-TVSPDGSLCASGGKDGQAMLWDLNE 223 K+ + ++++ +P G AS ++W E Sbjct: 389 KMMCQLYDPESSGISSLNEFNPMGDTLASA-MGYHILIWSEQE 430 >3W15-A nrPDB Length = 368 Score = 99.8 bits (247), Expect = 2e-21, Method: Composition-based stats. Identities = 55/320 (17%), Positives = 110/320 (34%), Gaps = 51/320 (15%) Query: 21 IATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISS-DGQFAL 79 +A + +L A D T+ ++ T E P + H V + + Q L Sbjct: 68 LAWNESHENQVLVAQGDGTLRLFDTTFKE----FPIAIFKEHEREVFSCNWNLVNRQNFL 123 Query: 80 SGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCK 139 S SWDG++++W + ++ + N I+ K Sbjct: 124 SSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMV-DPLNAIIL---------------KKK 167 Query: 140 YTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLA--NCKLKTNHIGHTGYLNT 197 + V +FSP+ +++SC + ++++ + K + N + H+G L Sbjct: 168 SFTGISKNRNCVYQAQFSPH-DQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSG-LEA 225 Query: 198 VTVSPD---GSLCASGGKDGQAMLWDLN----------EGKHLYTLD--GGDIINALCFS 242 +T + + A+GG D +WD+ + + G I + +S Sbjct: 226 LTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNPGQLHNSSCINEIPNAHGLAIRKVTWS 285 Query: 243 PNRY--WLCAATGPSIKIW-DLEGKIIVDELKQEVISTSSKA------EPPQCTSLAWSA 293 P+ + A+ + +IW DL + K + + WS Sbjct: 286 PHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSL 345 Query: 294 DGQ--TLFAGYTDNLVRVWQ 311 G+ + + D + VW Sbjct: 346 WGKPGYVASTAWDGNLFVWN 365 Score = 94.8 bits (234), Expect = 5e-20, Method: Composition-based stats. Identities = 53/269 (19%), Positives = 94/269 (34%), Gaps = 56/269 (20%) Query: 7 LRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYG------------- 53 K H V LS+S D +I +W R ++ Sbjct: 98 PIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVD 157 Query: 54 ------IPQRALRGHSHFVSDV---VISS-DGQFALSGSWDGTLRLWDLT--TGTTTRRF 101 + +++ G S + V S D LS S + L+D+ +G F Sbjct: 158 PLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNF 217 Query: 102 VGHTK-DVLSVAFSSDNRQIV-SGSRDKTIKLWNTLGVCKYTVQDE----------SHSE 149 + H+ + L+ F+ +V +G D I++W+ + K Q +H Sbjct: 218 LVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNPGQLHNSSCINEIPNAHGL 277 Query: 150 WVSCVRFSPNSSNPIIVSCGWDKLVKVW-NLANCKLKTN---------------HIGHTG 193 + V +SP+ SN I++S +D ++W +L+N K H+ Sbjct: 278 AIRKVTWSPHHSN-ILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSE 336 Query: 194 YLNTVTVSPDGS--LCASGGKDGQAMLWD 220 ++ S G AS DG +W+ Sbjct: 337 FVFGADWSLWGKPGYVASTAWDGNLFVWN 365 Score = 59.7 bits (143), Expect = 2e-09, Method: Composition-based stats. Identities = 28/211 (13%), Positives = 72/211 (34%), Gaps = 27/211 (12%) Query: 108 VLSVAFSSDN-RQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIV 166 + +A++ + Q++ D T++L++T + H V ++ + + Sbjct: 65 LFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFL- 123 Query: 167 SCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKH 226 S WD +K+W+ + + + V P ++ L + Sbjct: 124 SSSWDGSIKIWSPLRKQSLMTLTPRPLEITKM-VDPLNAII-------------LKKKSF 169 Query: 227 LYTLDGGDIINALCFSP-NRYWLCAATGPS-IKIWDLEGKIIVDELKQEVISTSSKAEPP 284 + + FSP ++ + + +G S ++D+ L + Sbjct: 170 TGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIR-------LPSGKNQNNFLVHSG 222 Query: 285 -QCTSLAWSADGQTLF-AGYTDNLVRVWQVT 313 + + ++ + G DN +R+W + Sbjct: 223 LEALTCDFNKYRPYVVATGGVDNAIRIWDIR 253 >1PI6-A nrPDB Length = 615 Score = 97.5 bits (241), Expect = 7e-21, Method: Composition-based stats. Identities = 56/305 (18%), Positives = 111/305 (36%), Gaps = 25/305 (8%) Query: 13 GHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVIS 72 GH+ + P ++ D +++ ++ + + R FV DV S Sbjct: 158 GHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFK--FSASDRTHHKQGSFVRDVEFS 215 Query: 73 SD-GQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSS---DNRQIVSGSRDKT 128 D G+F ++ D + +D +G + + V F+ D+++ + D T Sbjct: 216 PDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADAT 275 Query: 129 IKLWN-TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTN 187 I++W+ T C + V + II S D + + L + ++ Sbjct: 276 IRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRII-SLSLDGTLNFYELGHDEVLKT 334 Query: 188 HIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYW 247 GH + +TV+P SG DG+ M W + D ++I +L S + + Sbjct: 335 ISGHNKGITALTVNP----LISGSYDGRIMEWSSSSMHQ----DHSNLIVSLDNSKAQEY 386 Query: 248 LCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTL---FAGYTD 304 + ++K+ I E + S+ T++ + D + F G Sbjct: 387 SSISWDDTLKV----NGITKHEFGSQPKVASAN--NDGFTAVLTNDDDLLILQSFTGDII 440 Query: 305 NLVRV 309 VR+ Sbjct: 441 KSVRL 445 Score = 80.5 bits (197), Expect = 1e-15, Method: Composition-based stats. Identities = 58/369 (15%), Positives = 116/369 (31%), Gaps = 80/369 (21%) Query: 15 NGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSD 74 G + ++ + D TI +W +T + + + V V + + Sbjct: 253 QGGIFALSWL--DSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVA-TGN 309 Query: 75 GQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNT 134 G+ +S S DGTL ++L + GH K + ++ + ++SGS D I W++ Sbjct: 310 GR-IISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNP----LISGSYDGRIMEWSS 364 Query: 135 L-----GVCKYTVQDESHSEWVSCVRFSPN-----------SSNPIIVSCGWDKLVKVWN 178 D S ++ S + + S P + S D V Sbjct: 365 SSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLT 424 Query: 179 LANCKLKTNHIGHTGYLNTVTVSPDG-------SLCASGGKDG-QAMLWDLNEGKHLYTL 230 + L + +V ++ G + A G ++G ++ L++ + + L Sbjct: 425 NDDDLLILQSFT-GDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDL 483 Query: 231 DGG--DIINALCFSPNRYWLCAAT-GPSIKIWDLEGKII--------------------- 266 + + SP+ ++ A I ++DL+ + + Sbjct: 484 KTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFRTSKINAISWKPAE 543 Query: 267 --------------VDELKQEVISTSSKAEPPQCTSLAWSADG---------QTLFAGYT 303 L + S K +L DG TL + Sbjct: 544 KGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLWETPSTLVSSGA 603 Query: 304 DNLVRVWQV 312 D ++ W V Sbjct: 604 DACIKRWNV 612 Score = 78.2 bits (191), Expect = 4e-15, Method: Composition-based stats. Identities = 43/272 (15%), Positives = 87/272 (31%), Gaps = 26/272 (9%) Query: 65 FVSDVVISSDGQFAL-SGSWDGTLRLWDLTTGTTTR--RFVGH-TKDVLSVAFSS--DNR 118 F + + +R D +F GH + V +V FS ++ Sbjct: 20 FTTHLSYDPTTNAIAYPCGKSAFVRCLDDGDSKVPPVVQFTGHGSSVVTTVKFSPIKGSQ 79 Query: 119 QIVSGSRDKTIKLWN-TLGVCKYTVQDESHSE------WVSCVRFSPNSSNPIIVSCGWD 171 + SG + +W T +V+ SE +S + + +V G D Sbjct: 80 YLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEGRD 139 Query: 172 KLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCA-SGGKDGQAMLWDLNEGKHLYTL 230 + + GH+ +N + + + + G DG + + K + Sbjct: 140 NFGVFISWDSGNSLGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASD 199 Query: 231 DGG----DIINALCFSPN--RYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPP 284 + + FSP+ + + + I +D + + ++ + + Sbjct: 200 RTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDD-----QEPVQG 254 Query: 285 QCTSLAWSADGQTLFAGYTDNLVRVWQVTIGT 316 +L+W D Q D +RVW VT Sbjct: 255 GIFALSW-LDSQKFATVGADATIRVWDVTTSK 285 >5OV3-A nrPDB Length = 381 Score = 96.3 bits (238), Expect = 2e-20, Method: Composition-based stats. Identities = 47/259 (18%), Positives = 93/259 (35%), Gaps = 16/259 (6%) Query: 69 VVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKT 128 + G G DG + +WD T + H V S+ +S D ++VS S D Sbjct: 31 CTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNI 90 Query: 129 IKLWNTL-GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTN 187 + W+ L G C + + V++ P N ++V V + L++ K Sbjct: 91 VSQWDVLSGDCDQRFRF---PSPILKVQYHPRDQNKVLVCPMKSAPVML-TLSDSKHVVL 146 Query: 188 HIGHTGYLNTV-TVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLD------GGDIINALC 240 + LN V + G +G G+ ++ + + + I ++ Sbjct: 147 PVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIE 206 Query: 241 FSPNRY-WLCAATGPSIKIWDLEG-KIIVDELKQEVISTSSKAEPPQCT-SLAWSADGQT 297 F+ +L I+++D + + E + +S DG+ Sbjct: 207 FARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEY 266 Query: 298 LFAGYT-DNLVRVWQVTIG 315 + AG + + +W+ +IG Sbjct: 267 IVAGSARQHALYIWEKSIG 285 Score = 91.7 bits (226), Expect = 4e-19, Method: Composition-based stats. Identities = 49/302 (16%), Positives = 97/302 (32%), Gaps = 35/302 (11%) Query: 28 PDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTL 87 ++ D I++W + + H H V + S DG +S S D + Sbjct: 37 GTLLAVGCNDGRIVIWDFLTRGIA-----KIISAHIHPVCSLCWSRDGHKLVSASTDNIV 91 Query: 88 RLWDLTTGTTTRRFVGHTKDVLSVAFSSD--NRQIVSGSRDKTIKLWNTLGVCKYTVQDE 145 WD+ +G +RF +L V + N+ +V + + L TL K+ V Sbjct: 92 SQWDVLSGDCDQRFRF-PSPILKVQYHPRDQNKVLVCPMKSAPVML--TLSDSKHVVLPV 148 Query: 146 SHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNH-----IGHTGYLNTVTV 200 ++ V S + I + + V + L + +T + ++ Sbjct: 149 DDDSDLNVVA-SFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEF 207 Query: 201 SPDGSLCASGGKDGQAMLWDLNE------------GKHLYTLDGGDIINALCFSPNRYWL 248 + GS D ++D E + L L CFS + ++ Sbjct: 208 ARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYI 267 Query: 249 CAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVR 308 A + ++ E I ++ +AW + + + +V Sbjct: 268 VAGSARQHALYIWEKSI------GNLVKILHGTRGELLLDVAWHPVRPIIASISS-GVVS 320 Query: 309 VW 310 +W Sbjct: 321 IW 322 Score = 75.5 bits (184), Expect = 3e-14, Method: Composition-based stats. Identities = 39/275 (14%), Positives = 94/275 (34%), Gaps = 41/275 (14%) Query: 11 LKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETN----YGIPQRALRGHSHFV 66 + H V + + + ++SAS D + W + + + + P ++ H Sbjct: 63 ISAHIHPVCSLCWS-RDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQ 121 Query: 67 SDVVISS--DGQFALSGSWDGTLRL-WDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSG 123 + V++ L+ S + L D + +F I +G Sbjct: 122 NKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVA-----------SFDRRGEYIYTG 170 Query: 124 SRDKTIKLWNTLGVCK----YTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNL 179 + I + T S++ + + F+ S +I + D++++V++ Sbjct: 171 NAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTA--DRIIRVYDG 228 Query: 180 A------------NCKLKTNHIGHTGYLNTVTVSPDGSLCASGG-KDGQAMLWDLNEGKH 226 + + + T + S DG +G + +W+ + G Sbjct: 229 REILTCGRDGEPEPMQKLQDLVNRTPWKKCC-FSGDGEYIVAGSARQHALYIWEKSIGNL 287 Query: 227 LYTLDG--GDIINALCFSPNRYWLCAATGPSIKIW 259 + L G G+++ + + P R + + + + IW Sbjct: 288 VKILHGTRGELLLDVAWHPVRPIIASISSGVVSIW 322 Score = 64.7 bits (156), Expect = 5e-11, Method: Composition-based stats. Identities = 32/207 (15%), Positives = 69/207 (33%), Gaps = 12/207 (5%) Query: 109 LSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSC 168 L+ F+ + G D I +W+ L + +H V + +S + +VS Sbjct: 29 LTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKI-ISAHIHPVCSLCWSRDGHK--LVSA 85 Query: 169 GWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSP--DGSLCASGGKDGQAMLWDLNEGKH 226 D +V W++ + + V P + K ML + Sbjct: 86 STDNIVSQWDVLSGDCDQRFR-FPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHV 144 Query: 227 LYTLDGGDIINALCFSPNR--YWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPP 284 + +D +N + R Y I + + + +V + ++++ A Sbjct: 145 VLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTA--- 201 Query: 285 QCTSLAWSADGQTLFAGYTDNLVRVWQ 311 S+ ++ G D ++RV+ Sbjct: 202 -IKSIEFARKGSCFLINTADRIIRVYD 227 Score = 50.1 bits (118), Expect = 1e-06, Method: Composition-based stats. Identities = 20/70 (28%), Positives = 24/70 (34%), Gaps = 9/70 (12%) Query: 247 WLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNL 306 I IWD + I + A SL WS DG L + TDN+ Sbjct: 40 LAVGCNDGRIVIWDFLTRGI---------AKIISAHIHPVCSLCWSRDGHKLVSASTDNI 90 Query: 307 VRVWQVTIGT 316 V W V G Sbjct: 91 VSQWDVLSGD 100 >6F1U-h nrPDB Length = 612 Score = 95.9 bits (237), Expect = 2e-20, Method: Composition-based stats. Identities = 55/333 (16%), Positives = 111/333 (33%), Gaps = 49/333 (14%) Query: 18 VTQIATTPQFPDMILSASR----------DKTIIMWKLTRDETNYGIPQRALRGHSHFVS 67 V+ + + Q+P++++ AS D ++W + +T P+ S +S Sbjct: 256 VSCLDWSSQYPELLV-ASYNNNEDAPHEPDGVALVWNMKYKKT---TPEYVFHCQSAVMS 311 Query: 68 D--VVISSDGQFALSGSWDGTLRLWDLTTGT------TTRRFVGHTKDVLSVAF--SSDN 117 + + G++ G + LWD + T HT V V + + Sbjct: 312 ATFAKFHPN--LVVGGTYSGQIVLWDNRSNKRTPVQRTPLSAAAHTHPVYCVNVVGTQNA 369 Query: 118 RQIVSGSRDKTIKLWNTLGVCKY-----TVQDESHSEWVSCVRFSPNSSNPIIVSCGWDK 172 ++S S D I W+ + V +S + V+ + F P V + Sbjct: 370 HNLISISTDGKICSWSLDMLSHPQDSMELVHKQSKAVAVTSMSF-PVGDVNNFVVGSEEG 428 Query: 173 LVKVW--NLANCKLKTNHIGHTGYLNTVTVSPD------GSLCASGGKDGQAMLWDLNEG 224 V + + + GH G + + L + D LW Sbjct: 429 SVYTACRHGSKAGISEMFEGHQGPITGIHCHAAVGAVDFSHLFVTSSFDWTVKLWSTKNN 488 Query: 225 KHLYTLDGGDI-INALCFSPNRY-WLCAATG-PSIKIWDLEGKIIVDELKQEVISTSSKA 281 K LY+ + + + +SP G + +W+L V ++ S Sbjct: 489 KPLYSFEDNAGYVYDVMWSPTHPALFACVDGMGRLDLWNLNNDTEV------PTASISVE 542 Query: 282 EPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTI 314 P + W+ G+ + G ++ + ++ V Sbjct: 543 GNPALNRVRWTHSGREIAVGDSEGQIVIYDVGE 575 Score = 92.5 bits (228), Expect = 2e-19, Method: Composition-based stats. Identities = 53/286 (18%), Positives = 106/286 (37%), Gaps = 31/286 (10%) Query: 15 NGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQ-RALRGHSHFVSDVVI-- 71 V P++++ + I++W ++ + H+H V V + Sbjct: 306 QSAVMSATFAKFHPNLVVGGTYSGQIVLWDNRSNKRTPVQRTPLSAAAHTHPVYCVNVVG 365 Query: 72 SSDGQFALSGSWDGTLRLWDLTTGTTTRRFVG--HTK----DVLSVAFS-SDNRQIVSGS 124 + + +S S DG + W L + + + H + V S++F D V GS Sbjct: 366 TQNAHNLISISTDGKICSWSLDMLSHPQDSMELVHKQSKAVAVTSMSFPVGDVNNFVVGS 425 Query: 125 RDKTIKLWNTLGVCKY------TVQDESHSEWVSCVRFSPNSS----NPIIVSCGWDKLV 174 + ++ C++ + E H ++ + + + V+ +D V Sbjct: 426 EEGSV-----YTACRHGSKAGISEMFEGHQGPITGIHCHAAVGAVDFSHLFVTSSFDWTV 480 Query: 175 KVWNLANCKLKTNHIGHTGYLNTVTVSPDGS-LCASGGKDGQAMLWDLNEGKHLYT---- 229 K+W+ N K + + GY+ V SP L A G+ LW+LN + T Sbjct: 481 KLWSTKNNKPLYSFEDNAGYVYDVMWSPTHPALFACVDGMGRLDLWNLNNDTEVPTASIS 540 Query: 230 LDGGDIINALCF-SPNRYWLCAATGPSIKIWDLEGKIIVDELKQEV 274 ++G +N + + R + I I+D+ +I V + Sbjct: 541 VEGNPALNRVRWTHSGREIAVGDSEGQIVIYDVGEQIAVPRNDEWA 586 Score = 82.8 bits (203), Expect = 2e-16, Method: Composition-based stats. Identities = 51/293 (17%), Positives = 103/293 (35%), Gaps = 54/293 (18%) Query: 64 HFVSDVVISSDGQFALSGSW----------DGTLRLWDLTTGTTTRRFVGHT-KDVLSVA 112 VS + SS L S+ DG +W++ TT +V H V+S Sbjct: 254 RVVSCLDWSSQYPELLVASYNNNEDAPHEPDGVALVWNMKYKKTTPEYVFHCQSAVMSAT 313 Query: 113 FSSDN-RQIVSGSRDKTIKLWNTLGVCKYTVQ-----DESHSEWVSCVRFSPNSSNPIIV 166 F+ + +V G+ I LW+ + VQ +H+ V CV + ++ Sbjct: 314 FAKFHPNLVVGGTYSGQIVLWDNRSNKRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNLI 373 Query: 167 SCGWDKLVKVWNLANCKLKTNHIG--HTGY----LNTVTVSPDGSL--CASGGKDGQAM- 217 S D + W+L + + H + +++ P G + G ++G Sbjct: 374 SISTDGKICSWSLDMLSHPQDSMELVHKQSKAVAVTSMSF-PVGDVNNFVVGSEEGSVYT 432 Query: 218 ------------LWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKI 265 +++ ++G + + + A+ FS ++ ++ ++K+W + Sbjct: 433 ACRHGSKAGISEMFEGHQG-PITGIHCHAAVGAVDFS--HLFVTSSFDWTVKLWSTKNNK 489 Query: 266 IVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVR--VWQVTIGT 316 + + + WS LFA D + R +W + T Sbjct: 490 PLYSFEDNA---------GYVYDVMWSPTHPALFAC-VDGMGRLDLWNLNNDT 532 Score = 63.9 bits (154), Expect = 8e-11, Method: Composition-based stats. Identities = 27/134 (20%), Positives = 52/134 (38%), Gaps = 16/134 (11%) Query: 11 LKGHNGWVTQIATTP-----QFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHF 65 +GH G +T I F + +++S D T+ +W ++ P + ++ + Sbjct: 446 FEGHQGPITGIHCHAAVGAVDFSHLFVTSSFDWTVKLWSTKNNK-----PLYSFEDNAGY 500 Query: 66 VSDVVISSDGQ-FALSGSWDGTLRLWDLTTGTTTRR----FVGHTKDVLSVAFSSDNRQI 120 V DV+ S G L LW+L T G+ + V ++ R+I Sbjct: 501 VYDVMWSPTHPALFACVDGMGRLDLWNLNNDTEVPTASISVEGNPA-LNRVRWTHSGREI 559 Query: 121 VSGSRDKTIKLWNT 134 G + I +++ Sbjct: 560 AVGDSEGQIVIYDV 573 Score = 62.0 bits (149), Expect = 3e-10, Method: Composition-based stats. Identities = 28/195 (14%), Positives = 63/195 (32%), Gaps = 20/195 (10%) Query: 17 WVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHS---------HFVS 67 VT ++ + + S + ++ + R + GI + GH V Sbjct: 407 AVTSMSFPVGDVNNFVVGSEEGSV--YTACRHGSKAGISE-MFEGHQGPITGIHCHAAVG 463 Query: 68 DVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRD- 126 V S ++ S+D T++LW F + V V +S + + + Sbjct: 464 AVDFSH---LFVTSSFDWTVKLWSTKNNKPLYSFEDNAGYVYDVMWSPTHPALFACVDGM 520 Query: 127 KTIKLWNTLG-VCKYTVQDESHSEW-VSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKL 184 + LWN T ++ VR++ + I + + ++++ Sbjct: 521 GRLDLWNLNNDTEVPTASISVEGNPALNRVRWTHSGRE--IAVGDSEGQIVIYDVGEQIA 578 Query: 185 KTNHIGHTGYLNTVT 199 + + T+ Sbjct: 579 VPRNDEWARFGRTLA 593 Score = 45.1 bits (105), Expect = 4e-05, Method: Composition-based stats. Identities = 13/91 (14%), Positives = 33/91 (36%), Gaps = 2/91 (2%) Query: 2 TEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRG 61 T+ + + + G+V + +P P + + +W L D Sbjct: 485 TKNNKPLYSFEDNAGYVYDVMWSPTHPALFACVDGMGRLDLWNLNNDTEVPTASISV--E 542 Query: 62 HSHFVSDVVISSDGQFALSGSWDGTLRLWDL 92 + ++ V + G+ G +G + ++D+ Sbjct: 543 GNPALNRVRWTHSGREIAVGDSEGQIVIYDV 573 >2PM9-A nrPDB Length = 416 Score = 95.1 bits (235), Expect = 3e-20, Method: Composition-based stats. Identities = 50/292 (17%), Positives = 102/292 (34%), Gaps = 26/292 (8%) Query: 19 TQIATTPQFPDMILSASRD-KTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVIS-SDGQ 76 + + + I++ + D ++ ++ T + N HS V V + Sbjct: 71 NDLDWSHN--NKIIAGALDNGSLELYS-TNEANNAINSMARFSNHSSSVKTVKFNAKQDN 127 Query: 77 FALSGSWDGTLRLWDL---------TTGTTTRRFVGHTKDVLSVAFSSD-NRQIVSGSRD 126 SG +G + +WD+ T T + + +V+S+A++ S Sbjct: 128 VLASGGNNGEIFIWDMNKCTESPSNYTPLTPGQSMSSVDEVISLAWNQSLAHVFASAGSS 187 Query: 127 KTIKLWNTLGVCKYTVQDESHSEW-----VSCVRFSPNSSNPIIVSCGWDK--LVKVWNL 179 +W+ + + +S V + P +S + + G D + +W+L Sbjct: 188 NFASIWDLKAKKEVIHLSYTSPNSGIKQQLSVVEWHPKNSTRVATATGSDNDPSILIWDL 247 Query: 180 AN--CKLKTNHIGHTGYLNTVTV-SPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG-GDI 235 N L+T + GH + ++ D L S G+D +LW+ + L G+ Sbjct: 248 RNANTPLQTLNQGHQKGILSLDWCHQDEHLLLSSGRDNTVLLWNPESAEQLSQFPARGNW 307 Query: 236 INALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCT 287 F+P L A KI + + + L ++ T + Sbjct: 308 CFKTKFAPEAPDLFACASFDNKIEVQTLQNLTNTLDEQETETKQQESETDFW 359 Score = 90.1 bits (222), Expect = 1e-18, Method: Composition-based stats. Identities = 60/327 (18%), Positives = 112/327 (34%), Gaps = 52/327 (15%) Query: 22 ATTPQFPDMILSA----------SRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVI 71 A + +++S S D ++ +W L ++ I + +D+ Sbjct: 19 AWSHDKIPLLVSGTVSGTVDANFSTDSSLELWSLLAADSEKPIASLQV---DSKFNDLDW 75 Query: 72 SSDGQFALSGSWDGTLRLWDLTTGT----TTRRFVGHTKDVLSVAFS-SDNRQIVSGSRD 126 S + + +G+L L+ + RF H+ V +V F+ + + SG + Sbjct: 76 SHNNKIIAGALDNGSLELYSTNEANNAINSMARFSNHSSSVKTVKFNAKQDNVLASGGNN 135 Query: 127 KTIKLWN----TLGVCKYTVQDESHS----EWVSCVRFSPNSSNPIIVSCGWDKLVKVWN 178 I +W+ T YT S + V + ++ S + S G +W+ Sbjct: 136 GEIFIWDMNKCTESPSNYTPLTPGQSMSSVDEVISLAWN-QSLAHVFASAGSSNFASIWD 194 Query: 179 LANCKLKTNHI------GHTGYLNTVTVSPDGSL---CASGGK-DGQAMLWDLNE-GKHL 227 L K + G L+ V P S A+G D ++WDL L Sbjct: 195 LKAKKEVIHLSYTSPNSGIKQQLSVVEWHPKNSTRVATATGSDNDPSILIWDLRNANTPL 254 Query: 228 YTLD--GGDIINALCFS--PNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEP 283 TL+ I +L + L + ++ +W+ E + + A Sbjct: 255 QTLNQGHQKGILSLDWCHQDEHLLLSSGRDNTVLLWNPESAEQLSQFP---------ARG 305 Query: 284 PQCTSLAWSADGQTLFA-GYTDNLVRV 309 C ++ + LFA DN + V Sbjct: 306 NWCFKTKFAPEAPDLFACASFDNKIEV 332 Score = 86.3 bits (212), Expect = 2e-17, Method: Composition-based stats. Identities = 56/281 (19%), Positives = 99/281 (35%), Gaps = 47/281 (16%) Query: 70 VISSDG-QFALSG----------SWDGTLRLWDLTTGTTTRRFVGHTKDV--LSVAFSSD 116 S D +SG S D +L LW L + + D + +S + Sbjct: 19 AWSHDKIPLLVSGTVSGTVDANFSTDSSLELWSLLAADSEKPIASLQVDSKFNDLDWSHN 78 Query: 117 NRQIVSGSRDKTIKLWNTLGVCKYT---VQDESHSEWVSCVRFSPNSSNPIIVSCGWDKL 173 N+ I + +++L++T + +HS V V+F+ N ++ S G + Sbjct: 79 NKIIAGALDNGSLELYSTNEANNAINSMARFSNHSSSVKTVKFNAKQDN-VLASGGNNGE 137 Query: 174 VKVWNLANCK---------LKTNHIGHTGYLNTVTVSPD-GSLCASGGKDGQAMLWDLNE 223 + +W++ C + + ++ + + AS G A +WDL Sbjct: 138 IFIWDMNKCTESPSNYTPLTPGQSMSSVDEVISLAWNQSLAHVFASAGSSNFASIWDLKA 197 Query: 224 GKHLYTLDGGDI-------INALCFSP-NRYWLCAAT----GPSIKIWDLEGKIIVDELK 271 K + L ++ + + P N + AT PSI IWDL Sbjct: 198 KKEVIHLSYTSPNSGIKQQLSVVEWHPKNSTRVATATGSDNDPSILIWDLRNANT----- 252 Query: 272 QEVISTSSKAEPPQCTSLAW-SADGQTLFAGYTDNLVRVWQ 311 + T ++ SL W D L + DN V +W Sbjct: 253 --PLQTLNQGHQKGILSLDWCHQDEHLLLSSGRDNTVLLWN 291 Score = 85.5 bits (210), Expect = 3e-17, Method: Composition-based stats. Identities = 32/225 (14%), Positives = 71/225 (31%), Gaps = 18/225 (8%) Query: 11 LKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHS----HFV 66 H+ V + + +++ S + I +W + + + G S V Sbjct: 109 FSNHSSSVKTVKFNAKQDNVLASGGNNGEIFIWDMNKCTESPSNYTPLTPGQSMSSVDEV 168 Query: 67 SDVVISSDGQFA-LSGSWDGTLRLWDLTTGTTTRRF------VGHTKDVLSVAFSSDNRQ 119 + + S +WDL G + + V + N Sbjct: 169 ISLAWNQSLAHVFASAGSSNFASIWDLKAKKEVIHLSYTSPNSGIKQQLSVVEWHPKNST 228 Query: 120 IV---SGSR-DKTIKLWNTLGVCKYTVQD-ESHSEWVSCVRFSPNSSNPIIVSCGWDKLV 174 V +GS D +I +W+ + H + + + + + +++S G D V Sbjct: 229 RVATATGSDNDPSILIWDLRNANTPLQTLNQGHQKGILSLDWC-HQDEHLLLSSGRDNTV 287 Query: 175 KVWNLANCKLKTNHIGHTGYLNTVTVSPDGS-LCASGGKDGQAML 218 +WN + + + + +P+ L A D + + Sbjct: 288 LLWNPESAEQLSQFPARGNWCFKTKFAPEAPDLFACASFDNKIEV 332 Score = 51.2 bits (121), Expect = 6e-07, Method: Composition-based stats. Identities = 27/185 (14%), Positives = 58/185 (31%), Gaps = 21/185 (11%) Query: 152 SCVRFSPNSSNPIIVSC----------GWDKLVKVWNL--ANCKLKTNHIGHTGYLNTVT 199 + +S + P++VS D +++W+L A+ + + N + Sbjct: 16 ATFAWS-HDKIPLLVSGTVSGTVDANFSTDSSLELWSLLAADSEKPIASLQVDSKFNDLD 74 Query: 200 VSPDGSLCASGGKDGQAMLWDLNE-----GKHLYTLDGGDIINALCFS--PNRYWLCAAT 252 S + + A +G L+ NE + + + F+ + Sbjct: 75 WSHNNKIIAGALDNGSLELYSTNEANNAINSMARFSNHSSSVKTVKFNAKQDNVLASGGN 134 Query: 253 GPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSAD-GQTLFAGYTDNLVRVWQ 311 I IWD+ + S + + SLAW+ + + N +W Sbjct: 135 NGEIFIWDMNKCTESPSNYTPLTPGQSMSSVDEVISLAWNQSLAHVFASAGSSNFASIWD 194 Query: 312 VTIGT 316 + Sbjct: 195 LKAKK 199 Score = 48.9 bits (115), Expect = 3e-06, Method: Composition-based stats. Identities = 17/86 (19%), Positives = 33/86 (38%), Gaps = 7/86 (8%) Query: 6 TLRGTL-KGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSH 64 T TL +GH + + Q ++LS+ RD T+++W E P R + Sbjct: 252 TPLQTLNQGHQKGILSLDWCHQDEHLLLSSGRDNTVLLWNPESAEQLSQFPAR-----GN 306 Query: 65 FVSDVVISSDGQ-FALSGSWDGTLRL 89 + + + S+D + + Sbjct: 307 WCFKTKFAPEAPDLFACASFDNKIEV 332 >4OWR-A nrPDB Length = 339 Score = 94.8 bits (234), Expect = 5e-20, Method: Composition-based stats. Identities = 50/300 (16%), Positives = 98/300 (32%), Gaps = 66/300 (22%) Query: 18 VTQIATTPQF--PDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDG 75 + ++ +P + +++ S + W++ ++ IP+ A + H+ V DV S DG Sbjct: 13 IGCLSFSPPTLPGNFLIAGSWANDVRCWEVQ--DSGQTIPK-AQQMHTGPVLDVCWSDDG 69 Query: 76 QFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAF--SSDNRQIVSGSRDKTIKLWN 133 + S D T ++WDL++ + H V ++ + + + +++GS DKT+K W+ Sbjct: 70 SKVFTASCDKTAKMWDLSSNQAI-QIAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWD 128 Query: 134 TLGVCKYTVQDESHSEWVSCVRF------------------------------------- 156 T V + + V + Sbjct: 129 TRSSNPMMVLQLPERCYCADVIYPMAVVATAERGLIVYQLENQPSEFRRIESPLKHQHRC 188 Query: 157 -----SPNSSNPIIVSCGWDKLVKVWNL---ANCKLKTNHIGHTG------------YLN 196 + + V + + K H +N Sbjct: 189 VAIFKDKQNKPTGFALGSIEGRVAIHYINPPNPAKDNFTFKCHRSNGTNTSAPQDIYAVN 248 Query: 197 TVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLD-GGDIINALCFSPNRYWLCAATGPS 255 + P A+ G DG+ WD + L T + I+A CF+ N A+ Sbjct: 249 GIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQPISACCFNHNGNIFAYASSYD 308 Score = 70.9 bits (172), Expect = 8e-13, Method: Composition-based stats. Identities = 27/134 (20%), Positives = 53/134 (39%), Gaps = 6/134 (4%) Query: 144 DESHSEWVSCVRFSP-NSSNPIIVSCGWDKLVKVWNLAN--CKLKTNHIGHTGYLNTVTV 200 S + + C+ FSP +++ W V+ W + + + HTG + V Sbjct: 6 TSSPDDSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCW 65 Query: 201 SPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCF--SPNRYWLCAAT-GPSIK 257 S DGS + D A +WDL+ + + + + + +PN + + ++K Sbjct: 66 SDDGSKVFTASCDKTAKMWDLSSNQAIQIAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLK 125 Query: 258 IWDLEGKIIVDELK 271 WD + L+ Sbjct: 126 FWDTRSSNPMMVLQ 139 Score = 59.3 bits (142), Expect = 2e-09, Method: Composition-based stats. Identities = 16/132 (12%), Positives = 39/132 (29%), Gaps = 19/132 (14%) Query: 192 TGYLNTVTVSPD---GSLCASGGKDGQAMLWDLNEGKHLYTLD---GGDIINALCFSPNR 245 + ++ SP G+ +G W++ + + +C+S + Sbjct: 10 DDSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDG 69 Query: 246 Y-WLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAW--SADGQTLFAGY 302 A+ + K+WDL + ++ W + + + G Sbjct: 70 SKVFTASCDKTAKMWDLSSNQAIQ----------IAQHDAPVKTIHWIKAPNYSCVMTGS 119 Query: 303 TDNLVRVWQVTI 314 D ++ W Sbjct: 120 WDKTLKFWDTRS 131 >5YZG-2 nrPDB Length = 646 Score = 93.6 bits (231), Expect = 9e-20, Method: Composition-based stats. Identities = 42/239 (17%), Positives = 84/239 (35%), Gaps = 29/239 (12%) Query: 14 HNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISS 73 H +T + T D I++AS D + WK + + + R H + + +SS Sbjct: 89 HRDVITHVVCTK--TDFIITASHDGHVKFWKKIEEGIEF---VKHFRSHLGVIESIAVSS 143 Query: 74 DGQFALSGSWDGTLRLWDLTTGTTTRR-----FVGHTKDVLSVAFSSDNRQIVSGSRDKT 128 +G S D ++++D+ F G + + + + S Sbjct: 144 EGALFCSVGDDKAMKVFDVVNFDMINMLKLGYFPGQCEWIYCPG-DAISSVAASEKSTGK 202 Query: 129 IKLWNTLGVCKYTVQDES-HSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKT- 186 I +++ G + + H+ ++ +R +P +VS +++ W + K Sbjct: 203 IFIYDGRGDNQPLHIFDKLHTSPLTQIRLNPVYKA--VVSSDKSGMIEYWTGPPHEYKFP 260 Query: 187 --------------NHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLD 231 Y +V SPDG A+ G D + ++ GK + D Sbjct: 261 KNVNWEYKTDTDLYEFAKCKAYPTSVCFSPDGKKIATIGSDRKVRIFRFVTGKLMRVFD 319 Score = 83.2 bits (204), Expect = 1e-16, Method: Composition-based stats. Identities = 45/247 (18%), Positives = 90/247 (36%), Gaps = 22/247 (8%) Query: 88 RLW--DLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTV-QD 144 R++ +L + + R H + V + I++ S D +K W + V Sbjct: 71 RVYLDNLPSASMYERSYMHRDVITHVV-CTKTDFIITASHDGHVKFWKKIEEGIEFVKHF 129 Query: 145 ESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKL-----KTNHIGHTGYLNTVT 199 SH + + S S + S G DK +KV+++ N + G ++ Sbjct: 130 RSHLGVIESIAVS--SEGALFCSVGDDKAMKVFDVVNFDMINMLKLGYFPGQCEWIYCPG 187 Query: 200 VSPDGSLCASGGKDGQAMLWDLN-EGKHLYTLD--GGDIINALCFSPNRYWLCAATGPS- 255 S+ AS G+ ++D + + L+ D + + +P + ++ Sbjct: 188 -DAISSVAASEKSTGKIFIYDGRGDNQPLHIFDKLHTSPLTQIRLNPVYKAVVSSDKSGM 246 Query: 256 IKIWDLEG------KIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRV 309 I+ W K + E K + TS+ +S DG+ + +D VR+ Sbjct: 247 IEYWTGPPHEYKFPKNVNWEYKTDTDLYEFAKCKAYPTSVCFSPDGKKIATIGSDRKVRI 306 Query: 310 WQVTIGT 316 ++ G Sbjct: 307 FRFVTGK 313 Score = 43.5 bits (101), Expect = 1e-04, Method: Composition-based stats. Identities = 29/194 (14%), Positives = 55/194 (28%), Gaps = 59/194 (30%) Query: 11 LKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSD-- 68 + H G + IA + + S DK + ++ + + + G ++ Sbjct: 129 FRSHLGVIESIAVS-SEGALFCSVGDDKAMKVFDVVNFDMINMLKLGYFPGQCEWIYCPG 187 Query: 69 -----VVISS---------DGQ-------------------------FALSGSWDGTLRL 89 V S DG+ + S D + + Sbjct: 188 DAISSVAASEKSTGKIFIYDGRGDNQPLHIFDKLHTSPLTQIRLNPVYKAVVSSDKSGMI 247 Query: 90 -----------------WDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLW 132 W+ T T F SV FS D ++I + D+ ++++ Sbjct: 248 EYWTGPPHEYKFPKNVNWEYKTDTDLYEFAKCKAYPTSVCFSPDGKKIATIGSDRKVRIF 307 Query: 133 NTLGVCKYTVQDES 146 + V DES Sbjct: 308 RFVTGKLMRVFDES 321 >5CXB-B nrPDB Length = 369 Score = 92.1 bits (227), Expect = 3e-19, Method: Composition-based stats. Identities = 53/366 (14%), Positives = 104/366 (28%), Gaps = 74/366 (20%) Query: 8 RGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVS 67 + +GH G V +A P + + D T+ +W+L + L G V+ Sbjct: 14 QTIFRGHEGRVRSVAIDP-TGVALATGGDDGTVRVWELLTGRQ---VWSVKLNG-DEAVN 68 Query: 68 DVVISSDGQ---FALSGSWDGTLRL---------WDLTTGTTTRRFVGHTKD-------- 107 V A + D L + D + GH + Sbjct: 69 TVRWRPTKDTFILAAAAGEDIFLMIPTHPSVTPALDQASRDILNAGFGHATNGKQQANLP 128 Query: 108 ------------------------------VLSVAFSSDNRQI--VSGSRDKTIKLWNTL 135 + ++++ VS S ++ +TL Sbjct: 129 PGKEPPGKWARPGTRLEDEGVLLRITVRSTIKAISWHRRGDHFATVSPSGQRSSVAIHTL 188 Query: 136 GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYL 195 + + F P + + + ++ ++L +L ++ Sbjct: 189 SKHLTQIPFRKLNGLAQTASFHPLRPLFFVAT---QRSIRCYDLQKLELVKIVQPGAKWI 245 Query: 196 NTVTVSPDGSLCASGGKDGQAMLWDLN--EGKHLYTLDGGDI-INALCFSPNRY--WLCA 250 ++ V P G G D + LW + T+ I A+ F + A Sbjct: 246 SSFDVHPGGDNLVVGSYDKRL-LWHDLDLSNRPYKTMRFHTEAIRAVRFHKGGLPLFADA 304 Query: 251 ATGPSIKIWDLEGKIIVDELKQEVISTSS--KAEPP----QCTSLAWSADGQTLFAGYTD 304 + S++I+ GK+ D+L+ I K + W + D Sbjct: 305 SDDGSLQIF--HGKVPNDQLENPTIVPVKMLKGHKVVNKLGVLDIDWHPREPWCVSAGAD 362 Query: 305 NLVRVW 310 R+W Sbjct: 363 GTARLW 368 Score = 69.7 bits (169), Expect = 2e-12, Method: Composition-based stats. Identities = 49/287 (17%), Positives = 88/287 (30%), Gaps = 38/287 (13%) Query: 44 KLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFV- 102 + + Q RGH V V I G +G DGT+R+W+L TG Sbjct: 2 SPDELKPFPTVQQTIFRGHEGRVRSVAIDPTGVALATGGDDGTVRVWELLTGRQVWSVKL 61 Query: 103 GHTKDVLSVAFSSDNRQIV---SGSRDKTIKLWNTLGVCKYTVQDESHSEWVS-CVRFSP 158 + V +V + + + D + + D++ + ++ + Sbjct: 62 NGDEAVNTVRWRPTKDTFILAAAAGEDIFLMI--PTHPSVTPALDQASRDILNAGFGHAT 119 Query: 159 NSSNPIIVSCGWDKLVKVWNLANCKLKTN----HIGHTGYLNTVTVSPDGSLCASGGKDG 214 N + G + K W +L+ I + ++ G A+ G Sbjct: 120 NGKQQANLPPGKEPPGK-WARPGTRLEDEGVLLRITVRSTIKAISWHRRGDHFATVSPSG 178 Query: 215 QAMLWDLNEGKHLYTLDGG----------DIINALCFSPNRYWLCAATGPSIKIWDLEGK 264 Q ++TL + F P R AT SI+ +DL+ Sbjct: 179 Q------RSSVAIHTLSKHLTQIPFRKLNGLAQTASFHPLRPLFFVATQRSIRCYDLQKL 232 Query: 265 IIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQ 311 +V ++ +S G L G D + +W Sbjct: 233 ELVKIVQPGA---------KWISSFDVHPGGDNLVVGSYDKRL-LWH 269 Score = 60.5 bits (145), Expect = 9e-10, Method: Composition-based stats. Identities = 21/93 (22%), Positives = 37/93 (39%), Gaps = 8/93 (8%) Query: 6 TLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMW--KLTRD--ETNYGIPQRALRG 61 T++ H + + + AS D ++ ++ K+ D E +P + L+G Sbjct: 276 RPYKTMRFHTEAIRAVRFHKGGLPLFADASDDGSLQIFHGKVPNDQLENPTIVPVKMLKG 335 Query: 62 H----SHFVSDVVISSDGQFALSGSWDGTLRLW 90 H V D+ + +S DGT RLW Sbjct: 336 HKVVNKLGVLDIDWHPREPWCVSAGADGTARLW 368 Score = 47.8 bits (112), Expect = 6e-06, Method: Composition-based stats. Identities = 13/44 (29%), Positives = 19/44 (43%) Query: 274 VISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGTR 317 V T + + S+A G L G D VRVW++ G + Sbjct: 12 VQQTIFRGHEGRVRSVAIDPTGVALATGGDDGTVRVWELLTGRQ 55 >3JB9-S nrPDB Length = 488 Score = 91.7 bits (226), Expect = 3e-19, Method: Composition-based stats. Identities = 53/244 (21%), Positives = 101/244 (41%), Gaps = 18/244 (7%) Query: 63 SHFVSDVVISS-DGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIV 121 + + S + F L D L L D+ + +T + F G L+ + + ++ V Sbjct: 209 TESTTSFFPSPENSSFVLCLHKDELLCL-DIQSNSTLKIFEG---SALACCWLTSSKIAV 264 Query: 122 SGSRDKTIKLWNTLGVCKYTVQDESHSEWVS-CVRF-SPNSSNPIIVSCGWDKLVKVWNL 179 + + +I + +V + + S + V F + S +++ +K +++L Sbjct: 265 ATADAISIFEFPVSSSGLQSVGEPTSSIPIDEKVNFLQAHPSGEYLLAASNEK-CYIFSL 323 Query: 180 ANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTL-DGGDIINA 238 + H + ++ V PDG+L +G ++G+ ++ + G L + Sbjct: 324 KSQVYNITVAQH---ITSLAVHPDGNLFVAGLENGELRFFETSSGNELTKFGPHSSPVKT 380 Query: 239 LCFSPNRYWLCAAT--GPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTS-LAWSADG 295 L F N YWL T I IWDL +V ++ + T A TS L S+DG Sbjct: 381 LQFGENGYWLVVTTNDDSDIFIWDLRKSELVQKIPLQ---TKVAAVSLDITSQLLVSSDG 437 Query: 296 QTLF 299 +TL+ Sbjct: 438 ETLY 441 Score = 73.6 bits (179), Expect = 1e-13, Method: Composition-based stats. Identities = 37/207 (17%), Positives = 80/207 (38%), Gaps = 17/207 (8%) Query: 15 NGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSD 74 + V + P + +L+AS +K ++ L N + Q ++ + + D Sbjct: 295 DEKVNFLQAHPS-GEYLLAASNEK-CYIFSLKSQVYNITVAQH--------ITSLAVHPD 344 Query: 75 GQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQI-VSGSRDKTIKLWN 133 G ++G +G LR ++ ++G +F H+ V ++ F + + V+ + D I +W+ Sbjct: 345 GNLFVAGLENGELRFFETSSGNELTKFGPHSSPVKTLQFGENGYWLVVTTNDDSDIFIWD 404 Query: 134 TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKL-VKVWNLANCKLKTNHIGHT 192 VQ V+ V S ++VS + L V ++ ++ + H Sbjct: 405 LR--KSELVQKIPLQTKVAAVSLDITS--QLLVSSDGETLYVHIYVKSSKSWRCMSQTHV 460 Query: 193 GYLNTVTVSPD-GSLCASGGKDGQAML 218 ++ + + L S L Sbjct: 461 SSISNLVWLNELHQLLFSTSNGAILRL 487 Score = 49.7 bits (117), Expect = 1e-06, Method: Composition-based stats. Identities = 32/174 (18%), Positives = 62/174 (35%), Gaps = 29/174 (16%) Query: 152 SCVRFSPNSSNPIIVSC-GWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVS-PDGSLCAS 209 S F P+ N V C D+L+ + ++ + G + + S A Sbjct: 211 STTSFFPSPENSSFVLCLHKDELLCL-DIQSNSTLKIFEG-----SALACCWLTSSKIAV 264 Query: 210 GGKDGQAMLWDLNE--------GKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDL 261 D +++ G+ ++ + +N L P+ +L AA+ I+ L Sbjct: 265 ATADA-ISIFEFPVSSSGLQSVGEPTSSIPIDEKVNFLQAHPSGEYLLAASNEKCYIFSL 323 Query: 262 EGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIG 315 + ++ + Q TSLA DG AG + +R ++ + G Sbjct: 324 KSQVYNITVAQH------------ITSLAVHPDGNLFVAGLENGELRFFETSSG 365 Score = 41.2 bits (95), Expect = 5e-04, Method: Composition-based stats. Identities = 17/120 (14%), Positives = 46/120 (38%), Gaps = 8/120 (6%) Query: 14 HNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISS 73 H+ V + ++++ + D I +W L + E IP + V+ V + Sbjct: 374 HSSPVKTLQFGENGYWLVVTTNDDSDIFIWDLRKSELVQKIPLQT------KVAAVSLDI 427 Query: 74 DGQFALSG-SWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAF-SSDNRQIVSGSRDKTIKL 131 Q +S + ++ ++ + H + ++ + + ++ + S S ++L Sbjct: 428 TSQLLVSSDGETLYVHIYVKSSKSWRCMSQTHVSSISNLVWLNELHQLLFSTSNGAILRL 487 >5A9Q-2 nrPDB Length = 326 Score = 89.0 bits (219), Expect = 2e-18, Method: Composition-based stats. Identities = 40/221 (18%), Positives = 76/221 (34%), Gaps = 24/221 (10%) Query: 8 RGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVS 67 L+GH ++ + P+ I S S D T +W L +T + + HS Sbjct: 117 YKVLEGHTDFINGLVFDPKEGQEIASVSDDHTCRIWNLEGVQTAHFVL------HSPG-M 169 Query: 68 DVVISSDGQF-ALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRD 126 V + F + +GT+R +DL ++S + N V Sbjct: 170 SVCWHPEETFKLMVAEKNGTIRFYDLLAQQAILSLESEQVPLMSAHWCLKNTFKVGAVAG 229 Query: 127 KTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKT 186 +W+ + H + R+S S N + + G+ + + + Sbjct: 230 NDWLIWDITRSSYPQNKRPVHMDRACLFRWSTISEN-LFATTGYPGKMA------SQFQI 282 Query: 187 NHIGHTGYL--------NTVTVSPDGSLCASGGKDGQAMLW 219 +H+GH + + ++ LC GG D + + W Sbjct: 283 HHLGHPQPILMGSVAVGSGLSWHRTLPLCVIGG-DHKLLFW 322 Score = 80.1 bits (196), Expect = 1e-15, Method: Composition-based stats. Identities = 36/230 (15%), Positives = 73/230 (31%), Gaps = 23/230 (10%) Query: 15 NGWVTQIATTP----QFPDMILSASRD----KTIIMWKLTRDETNYGIPQRALRGHSHFV 66 +V + P ++I + T + D H V Sbjct: 16 EDYVHVVEFNPFENGDSGNLIAYGGNNYVVIGTCTFQEEEADVEGIQYKTLRTFHHGVRV 75 Query: 67 SDVVISSDGQF--------ALSGSWDGTLRLW--DLTTGTTTRRFVGHTKDVLSVAFSS- 115 + S + + + + D +RL+ DL + GHT + + F Sbjct: 76 DGIAWSPETRLDSLPPVIKFCTSAADMKIRLFTSDLQDKNEYKVLEGHTDFINGLVFDPK 135 Query: 116 DNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVK 175 + ++I S S D T ++WN GV T HS V + P + ++V+ ++ Sbjct: 136 EGQEIASVSDDHTCRIWNLEGV--QTAHFVLHS-PGMSVCWHPEETFKLMVAEKN-GTIR 191 Query: 176 VWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGK 225 ++L + + L + + ++WD+ Sbjct: 192 FYDLLAQQAILSLESEQVPLMSAHWCLKNTFKVGAVAGNDWLIWDITRSS 241 Score = 78.2 bits (191), Expect = 5e-15, Method: Composition-based stats. Identities = 33/177 (18%), Positives = 68/177 (38%), Gaps = 12/177 (6%) Query: 117 NRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNP------IIVSCGW 170 N +V G+ + + G+ T++ H V + +SP + + Sbjct: 41 NNYVVIGTCTFQEEEADVEGIQYKTLRTFHHGVRVDGIAWSPETRLDSLPPVIKFCTSAA 100 Query: 171 DKLVKVW--NLANCKLKTNHIGHTGYLNTVTVSP-DGSLCASGGKDGQAMLWDLNEGKHL 227 D ++++ +L + GHT ++N + P +G AS D +W+L EG Sbjct: 101 DMKIRLFTSDLQDKNEYKVLEGHTDFINGLVFDPKEGQEIASVSDDHTCRIWNL-EGVQT 159 Query: 228 YTLDGGDIINALCFSPNRYW--LCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAE 282 ++C+ P + + A +I+ +DL + + L+ E + S Sbjct: 160 AHFVLHSPGMSVCWHPEETFKLMVAEKNGTIRFYDLLAQQAILSLESEQVPLMSAHW 216 Score = 53.2 bits (126), Expect = 1e-07, Method: Composition-based stats. Identities = 24/145 (16%), Positives = 49/145 (33%), Gaps = 28/145 (19%) Query: 192 TGYLNTVTVSP-----DGSLCASGGKD----GQAMLWDLNEG------KHLYTLDGGDII 236 Y++ V +P G+L A GG + G + K L T G + Sbjct: 16 EDYVHVVEFNPFENGDSGNLIAYGGNNYVVIGTCTFQEEEADVEGIQYKTLRTFHHGVRV 75 Query: 237 NALCFSPNRYWLC-------AATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSL 289 + + +SP + +KI ++ +L+ + + L Sbjct: 76 DGIAWSPETRLDSLPPVIKFCTSAADMKI-----RLFTSDLQDKNEYKVLEGHTDFINGL 130 Query: 290 AWSA-DGQTLFAGYTDNLVRVWQVT 313 + +GQ + + D+ R+W + Sbjct: 131 VFDPKEGQEIASVSDDHTCRIWNLE 155 >6EM1-m nrPDB Length = 807 Score = 88.6 bits (218), Expect = 3e-18, Method: Composition-based stats. Identities = 60/378 (15%), Positives = 116/378 (30%), Gaps = 87/378 (23%) Query: 13 GHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNY-GIPQRALRGHSHFVSDVVI 71 GH G V ++ P + + S D T+ +W++ Y + + + Sbjct: 435 GHKGKVRTLSIDP-SGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIECIEW 493 Query: 72 SSD---GQFALSGSWDGTLRL-----WDLTTGTTTR--------RFVGHTKDVLSVAFSS 115 + D G A++ + L + +D+ T+ F K L V + Sbjct: 494 NPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLEVNENG 553 Query: 116 DN------------------------------RQIVSGSRDKTIKL--WNTLGVCKYTVQ 143 D ++ S KT+K W+ G TVQ Sbjct: 554 DGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHRKGDYFVTVQ 613 Query: 144 DES-------HSEW--------------VSCVRFSPNSSNPIIVSCGWDKLVKVWNLANC 182 +S H + +F P + S + V++++L+ Sbjct: 614 PDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVCS---QRYVRIYDLSQQ 670 Query: 183 KLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLW---DLNEGKHLYTLDGGDIINAL 239 L + +L+ + + P G + D + LW DL + + ++ Sbjct: 671 ILVKKLLPGARWLSKIDIHPRGDNLIASSFDKRV-LWHDLDLASTPYKTLRYHEKAVRSV 729 Query: 240 CFSPNRYWL-CAATGPSIKIW------DLEGKIIVDELKQEVISTSSKAEPPQCTSLAWS 292 F AA +I ++ D+ ++ LK+ ++ W Sbjct: 730 NFHKKLPLFSSAADDGTIHVFHATVYDDMMKNPMIVPLKK--LTGHKVINSLGVLDAIWH 787 Query: 293 ADGQTLFAGYTDNLVRVW 310 LF+ DN R+W Sbjct: 788 PREAWLFSAGADNTARLW 805 Score = 76.3 bits (186), Expect = 2e-14, Method: Composition-based stats. Identities = 47/289 (16%), Positives = 90/289 (31%), Gaps = 42/289 (14%) Query: 55 PQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRF------VGHTKDV 108 GH V + I G + +GS DGT+R+W++ TG R + Sbjct: 429 CSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHI 488 Query: 109 LSVAFSSD-NRQIVSGSRDKTIKL-------WNTLGVCKYTVQDE----------SHSEW 150 + ++ D N I++ + + I L ++ K ++D + Sbjct: 489 ECIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLE 548 Query: 151 VSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTN----HIGHTGYLNTVTVSPDGSL 206 V+ K V WN + K I + ++ G Sbjct: 549 VNENGDGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHRKGDY 608 Query: 207 CASG---GKDGQAMLWDLNEGKHLYTL-DGGDIINALCFSPNRYWLCAATGPSIKIWDLE 262 + + ++ +++ II F P + L + ++I+DL Sbjct: 609 FVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVCSQRYVRIYDLS 668 Query: 263 GKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQ 311 +I+V +L + + G L A D V +W Sbjct: 669 QQILVKKLLPGA---------RWLSKIDIHPRGDNLIASSFDKRV-LWH 707 Score = 66.6 bits (161), Expect = 1e-11, Method: Composition-based stats. Identities = 34/251 (13%), Positives = 82/251 (32%), Gaps = 43/251 (17%) Query: 96 TTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEW----- 150 + + GH V +++ + +GS D T+++W L + E Sbjct: 428 RCSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYH 487 Query: 151 VSCVRFSPNSSNPIIVSCGWDKL------VKVWNLANCKLKTNHIGH------TGYLNTV 198 + C+ ++P+++N I+ + + + +++ N G T + + Sbjct: 488 IECIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNL 547 Query: 199 TVSPDGSLCASGGKDG-----------QAMLWDLNEGKHL-----YTLDGGDIINALCFS 242 V+ +G G +DG Q W+ K L T+ + L + Sbjct: 548 EVNENGD----GDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWH 603 Query: 243 PNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGY 302 + S +++ ++ + + + K + LF Sbjct: 604 RKGDYFVTVQPDSGN-----TSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVCS 658 Query: 303 TDNLVRVWQVT 313 VR++ ++ Sbjct: 659 Q-RYVRIYDLS 668 Score = 61.2 bits (147), Expect = 5e-10, Method: Composition-based stats. Identities = 25/93 (26%), Positives = 37/93 (39%), Gaps = 9/93 (9%) Query: 6 TLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDE----TNYGIPQRALRG 61 T TL+ H V + + P + SA+ D TI ++ T + +P + L G Sbjct: 714 TPYKTLRYHEKAVRSVNFHKKLP-LFSSAADDGTIHVFHATVYDDMMKNPMIVPLKKLTG 772 Query: 62 H----SHFVSDVVISSDGQFALSGSWDGTLRLW 90 H S V D + + S D T RLW Sbjct: 773 HKVINSLGVLDAIWHPREAWLFSAGADNTARLW 805 Score = 47.4 bits (111), Expect = 8e-06, Method: Composition-based stats. Identities = 12/42 (28%), Positives = 17/42 (40%) Query: 275 ISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGT 316 ST + +L+ G L G D VRVW++ G Sbjct: 429 CSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGR 470 >3EI3-B nrPDB Length = 383 Score = 88.2 bits (217), Expect = 4e-18, Method: Composition-based stats. Identities = 57/336 (16%), Positives = 110/336 (32%), Gaps = 42/336 (12%) Query: 2 TEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRG 61 + L T + VT + P P + S+ II+W I G Sbjct: 60 LKSYKLHRTASPFDRRVTSLEWHPTHPTTVAVGSKGGDIILWDYDVQNKTSFIQG---MG 116 Query: 62 HSHFVSDVVISS-DGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTK---DVLSVAFSSDN 117 ++ + + + S G L D +G+ + F V S Sbjct: 117 PGDAITGMKFNQFNTNQLFVSSIRGATTLRDF-SGSVIQVFAKTDSWDYWYCCVDVSVSR 175 Query: 118 RQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVW 177 + + +G D T +L +++ H V+ F+P ++ + D VK+W Sbjct: 176 QMLATG--DSTGRLLLLGLDGHEIFKEKLHKAKVTHAEFNPRCD-WLMATSSVDATVKLW 232 Query: 178 NLANCKLKTNHIG---HTGYLNTVTVSP-DGSLCASGGKDGQAML---WDLNEGKHLYTL 230 +L N K K ++I H +N +P D + + + + + +D ++ + Sbjct: 233 DLRNIKDKNSYIAEMPHEKPVNAAYFNPTDSTKLLTTDQRNEIRVYSSYDWSKPDQIIIH 292 Query: 231 DG----GDIINALCFSPNRYWLCAA----------TGPSIKIWDLEGKIIVDELKQEVIS 276 + P + A +I I+D +V +L+ + Sbjct: 293 PHRQFQHLTPIKATWHPMYDLIVAGRYPDDQLLLNDKRTIDIYDANSGGLVHQLRDPNAA 352 Query: 277 TSSKAEPPQCTSLA-WSADGQTLFAGYTDNLVRVWQ 311 SL +S G L +G N + +W Sbjct: 353 --------GIISLNKFSPTGDVLASGMGFN-ILIWN 379 Score = 55.1 bits (131), Expect = 4e-08, Method: Composition-based stats. Identities = 28/186 (15%), Positives = 66/186 (35%), Gaps = 24/186 (12%) Query: 14 HNGWVTQIATTPQFPDMILSASRDKTIIMWKLTR-DETNYGIPQRALRGHSHFVSDVVIS 72 H VT P+ ++ ++S D T+ +W L + N I + H V+ + Sbjct: 203 HKAKVTHAEFNPRCDWLMATSSVDATVKLWDLRNIKDKNSYIAE---MPHEKPVNAAYFN 259 Query: 73 S-DGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKD------VLSVAFSSDNRQIVSG-- 123 D L+ +R++ + + + H + + IV+G Sbjct: 260 PTDSTKLLTTDQRNEIRVYSSYDWSKPDQIIIHPHRQFQHLTPIKATWHPMYDLIVAGRY 319 Query: 124 -------SRDKTIKLWNTLGVCKYTVQDESHSEWVSCV-RFSPNSSNPIIVSCGWDKLVK 175 + +TI +++ + ++ + + +FSP +++ G + Sbjct: 320 PDDQLLLNDKRTIDIYDANSGGLVHQLRDPNAAGIISLNKFSPTGD---VLASGMGFNIL 376 Query: 176 VWNLAN 181 +WN + Sbjct: 377 IWNRED 382 Score = 42.4 bits (98), Expect = 3e-04, Method: Composition-based stats. Identities = 28/178 (15%), Positives = 59/178 (33%), Gaps = 41/178 (23%) Query: 178 NLANCKLKTNHIGHTGYLNTVTVSPDG-SLCASGGKDGQAMLWDLNEGKHLYTLDG---G 233 +L + KL + ++ P + A G K G +LWD + + G G Sbjct: 59 SLKSYKLHRTASPFDRRVTSLEWHPTHPTTVAVGSKGGDIILWDYDVQNKTSFIQGMGPG 118 Query: 234 DIINALCFSP---NRYWLCAA---------TGPSIKI------WDLEGKIIVDELKQEVI 275 D I + F+ N+ ++ + +G I++ WD + + ++++ Sbjct: 119 DAITGMKFNQFNTNQLFVSSIRGATTLRDFSGSVIQVFAKTDSWDYWYCCVDVSVSRQML 178 Query: 276 STS------------------SKAEPPQCTSLAWSADGQTL-FAGYTDNLVRVWQVTI 314 +T K + T ++ L D V++W + Sbjct: 179 ATGDSTGRLLLLGLDGHEIFKEKLHKAKVTHAEFNPRCDWLMATSSVDATVKLWDLRN 236 >6C0F-s nrPDB Length = 807 Score = 87.8 bits (216), Expect = 5e-18, Method: Composition-based stats. Identities = 60/378 (15%), Positives = 116/378 (30%), Gaps = 87/378 (23%) Query: 13 GHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNY-GIPQRALRGHSHFVSDVVI 71 GH G V ++ P + + S D T+ +W++ Y + + + Sbjct: 435 GHKGKVRTLSIDPS-GLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIECIEW 493 Query: 72 SSD---GQFALSGSWDGTLRL-----WDLTTGTTTR--------RFVGHTKDVLSVAFSS 115 + D G A++ + L + +D+ T+ F K L V + Sbjct: 494 NPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLEVNENG 553 Query: 116 DN------------------------------RQIVSGSRDKTIKL--WNTLGVCKYTVQ 143 D ++ S KT+K W+ G TVQ Sbjct: 554 DGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHRKGDYFVTVQ 613 Query: 144 DES-------HSEW--------------VSCVRFSPNSSNPIIVSCGWDKLVKVWNLANC 182 +S H + +F P + S + V++++L+ Sbjct: 614 PDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVCS---QRYVRIYDLSQQ 670 Query: 183 KLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLW---DLNEGKHLYTLDGGDIINAL 239 L + +L+ + + P G + D + LW DL + + ++ Sbjct: 671 ILVKKLLPGARWLSKIDIHPRGDNLIASSFDKRV-LWHDLDLASTPYKTLRYHEKAVRSV 729 Query: 240 CFSPNRYWL-CAATGPSIKIW------DLEGKIIVDELKQEVISTSSKAEPPQCTSLAWS 292 F AA +I ++ D+ ++ LK+ ++ W Sbjct: 730 NFHKKLPLFSSAADDGTIHVFHATVYDDMMKNPMIVPLKK--LTGHKVINSLGVLDAIWH 787 Query: 293 ADGQTLFAGYTDNLVRVW 310 LF+ DN R+W Sbjct: 788 PREAWLFSAGADNTARLW 805 Score = 75.5 bits (184), Expect = 2e-14, Method: Composition-based stats. Identities = 47/289 (16%), Positives = 90/289 (31%), Gaps = 42/289 (14%) Query: 55 PQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRF------VGHTKDV 108 GH V + I G + +GS DGT+R+W++ TG R + Sbjct: 429 CSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHI 488 Query: 109 LSVAFSSD-NRQIVSGSRDKTIKL-------WNTLGVCKYTVQDE----------SHSEW 150 + ++ D N I++ + + I L ++ K ++D + Sbjct: 489 ECIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLE 548 Query: 151 VSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTN----HIGHTGYLNTVTVSPDGSL 206 V+ K V WN + K I + ++ G Sbjct: 549 VNENGDGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHRKGDY 608 Query: 207 CASG---GKDGQAMLWDLNEGKHLYTL-DGGDIINALCFSPNRYWLCAATGPSIKIWDLE 262 + + ++ +++ II F P + L + ++I+DL Sbjct: 609 FVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVCSQRYVRIYDLS 668 Query: 263 GKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQ 311 +I+V +L + + G L A D V +W Sbjct: 669 QQILVKKLLPGA---------RWLSKIDIHPRGDNLIASSFDKRV-LWH 707 Score = 66.3 bits (160), Expect = 2e-11, Method: Composition-based stats. Identities = 34/251 (13%), Positives = 82/251 (32%), Gaps = 43/251 (17%) Query: 96 TTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEW----- 150 + + GH V +++ + +GS D T+++W L + E Sbjct: 428 RCSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYH 487 Query: 151 VSCVRFSPNSSNPIIVSCGWDKL------VKVWNLANCKLKTNHIGH------TGYLNTV 198 + C+ ++P+++N I+ + + + +++ N G T + + Sbjct: 488 IECIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNL 547 Query: 199 TVSPDGSLCASGGKDG-----------QAMLWDLNEGKHL-----YTLDGGDIINALCFS 242 V+ +G G +DG Q W+ K L T+ + L + Sbjct: 548 EVNENGD----GDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWH 603 Query: 243 PNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGY 302 + S +++ ++ + + + K + LF Sbjct: 604 RKGDYFVTVQPDSGN-----TSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVCS 658 Query: 303 TDNLVRVWQVT 313 VR++ ++ Sbjct: 659 Q-RYVRIYDLS 668 Score = 61.2 bits (147), Expect = 6e-10, Method: Composition-based stats. Identities = 25/93 (26%), Positives = 37/93 (39%), Gaps = 9/93 (9%) Query: 6 TLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDE----TNYGIPQRALRG 61 T TL+ H V + + P + SA+ D TI ++ T + +P + L G Sbjct: 714 TPYKTLRYHEKAVRSVNFHKKLP-LFSSAADDGTIHVFHATVYDDMMKNPMIVPLKKLTG 772 Query: 62 H----SHFVSDVVISSDGQFALSGSWDGTLRLW 90 H S V D + + S D T RLW Sbjct: 773 HKVINSLGVLDAIWHPREAWLFSAGADNTARLW 805 Score = 47.4 bits (111), Expect = 9e-06, Method: Composition-based stats. Identities = 12/42 (28%), Positives = 17/42 (40%) Query: 275 ISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGT 316 ST + +L+ G L G D VRVW++ G Sbjct: 429 CSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGR 470 >6CB1-s nrPDB Length = 569 Score = 87.4 bits (215), Expect = 8e-18, Method: Composition-based stats. Identities = 60/378 (15%), Positives = 116/378 (30%), Gaps = 87/378 (23%) Query: 13 GHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNY-GIPQRALRGHSHFVSDVVI 71 GH G V ++ P + + S D T+ +W++ Y + + + Sbjct: 197 GHKGKVRTLSIDPS-GLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIECIEW 255 Query: 72 SSD---GQFALSGSWDGTLRL-----WDLTTGTTTR--------RFVGHTKDVLSVAFSS 115 + D G A++ + L + +D+ T+ F K L V + Sbjct: 256 NPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLEVNENG 315 Query: 116 DN------------------------------RQIVSGSRDKTIKL--WNTLGVCKYTVQ 143 D ++ S KT+K W+ G TVQ Sbjct: 316 DGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHRKGDYFVTVQ 375 Query: 144 DES-------HSEW--------------VSCVRFSPNSSNPIIVSCGWDKLVKVWNLANC 182 +S H + +F P + S + V++++L+ Sbjct: 376 PDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVCS---QRYVRIYDLSQQ 432 Query: 183 KLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLW---DLNEGKHLYTLDGGDIINAL 239 L + +L+ + + P G + D + LW DL + + ++ Sbjct: 433 ILVKKLLPGARWLSKIDIHPRGDNLIASSFDKRV-LWHDLDLASTPYKTLRYHEKAVRSV 491 Query: 240 CFSPNRYWL-CAATGPSIKIW------DLEGKIIVDELKQEVISTSSKAEPPQCTSLAWS 292 F AA +I ++ D+ ++ LK+ ++ W Sbjct: 492 NFHKKLPLFSSAADDGTIHVFHATVYDDMMKNPMIVPLKK--LTGHKVINSLGVLDAIWH 549 Query: 293 ADGQTLFAGYTDNLVRVW 310 LF+ DN R+W Sbjct: 550 PREAWLFSAGADNTARLW 567 Score = 75.1 bits (183), Expect = 3e-14, Method: Composition-based stats. Identities = 47/289 (16%), Positives = 90/289 (31%), Gaps = 42/289 (14%) Query: 55 PQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRF------VGHTKDV 108 GH V + I G + +GS DGT+R+W++ TG R + Sbjct: 191 CSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHI 250 Query: 109 LSVAFSSD-NRQIVSGSRDKTIKL-------WNTLGVCKYTVQDE----------SHSEW 150 + ++ D N I++ + + I L ++ K ++D + Sbjct: 251 ECIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLE 310 Query: 151 VSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTN----HIGHTGYLNTVTVSPDGSL 206 V+ K V WN + K I + ++ G Sbjct: 311 VNENGDGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHRKGDY 370 Query: 207 CASG---GKDGQAMLWDLNEGKHLYTL-DGGDIINALCFSPNRYWLCAATGPSIKIWDLE 262 + + ++ +++ II F P + L + ++I+DL Sbjct: 371 FVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVCSQRYVRIYDLS 430 Query: 263 GKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQ 311 +I+V +L + + G L A D V +W Sbjct: 431 QQILVKKLLPGA---------RWLSKIDIHPRGDNLIASSFDKRV-LWH 469 Score = 65.9 bits (159), Expect = 2e-11, Method: Composition-based stats. Identities = 34/251 (13%), Positives = 82/251 (32%), Gaps = 43/251 (17%) Query: 96 TTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEW----- 150 + + GH V +++ + +GS D T+++W L + E Sbjct: 190 RCSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYH 249 Query: 151 VSCVRFSPNSSNPIIVSCGWDKL------VKVWNLANCKLKTNHIGH------TGYLNTV 198 + C+ ++P+++N I+ + + + +++ N G T + + Sbjct: 250 IECIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNL 309 Query: 199 TVSPDGSLCASGGKDG-----------QAMLWDLNEGKHL-----YTLDGGDIINALCFS 242 V+ +G G +DG Q W+ K L T+ + L + Sbjct: 310 EVNENGD----GDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWH 365 Query: 243 PNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGY 302 + S +++ ++ + + + K + LF Sbjct: 366 RKGDYFVTVQPDSGN-----TSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVCS 420 Query: 303 TDNLVRVWQVT 313 VR++ ++ Sbjct: 421 Q-RYVRIYDLS 430 Score = 60.9 bits (146), Expect = 7e-10, Method: Composition-based stats. Identities = 25/93 (26%), Positives = 37/93 (39%), Gaps = 9/93 (9%) Query: 6 TLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDE----TNYGIPQRALRG 61 T TL+ H V + + P + SA+ D TI ++ T + +P + L G Sbjct: 476 TPYKTLRYHEKAVRSVNFHKKLP-LFSSAADDGTIHVFHATVYDDMMKNPMIVPLKKLTG 534 Query: 62 H----SHFVSDVVISSDGQFALSGSWDGTLRLW 90 H S V D + + S D T RLW Sbjct: 535 HKVINSLGVLDAIWHPREAWLFSAGADNTARLW 567 Score = 47.4 bits (111), Expect = 9e-06, Method: Composition-based stats. Identities = 12/42 (28%), Positives = 17/42 (40%) Query: 275 ISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGT 316 ST + +L+ G L G D VRVW++ G Sbjct: 191 CSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGR 232 >6BX3-B nrPDB Length = 412 Score = 85.5 bits (210), Expect = 3e-17, Method: Composition-based stats. Identities = 59/350 (16%), Positives = 117/350 (33%), Gaps = 55/350 (15%) Query: 5 MTLRGTLKGHNGWVT----------QIATTPQFPDMILSASRDKTIIMWKLTRDETNYGI 54 LK H +T + +P D + + ++++ + + Sbjct: 5 QDPFAVLKEHPEKLTHTIENPLRTECLQFSP-CGDYLALGCANGALVIYDMDTFRPI-CV 62 Query: 55 PQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFS 114 P L H ++ + S DG+ L+ S D +++LWDL+ + + + + + Sbjct: 63 PGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWL 122 Query: 115 SDNRQIVSG-------------SRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSS 161 R++ S D L + + + + H +V Sbjct: 123 DAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPD-HG-YVLVCTVHTKHP 180 Query: 162 NPIIV--SCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLW 219 N IIV S GW K +L + + + + + VS +G A D + Sbjct: 181 NIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQY 240 Query: 220 DLN---EGKHLY-TLDGGD-------IINALCFSPN--RYWLCAATGPS---IKIWDLEG 263 +++ E + TL+ N + FS N Y + + G S + IW+ Sbjct: 241 EISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTS 300 Query: 264 KIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFA-GYTDNLVRVWQV 312 +V L+ + + W ++ + G+ V VW V Sbjct: 301 GTLVRVLE---------GAEEELIDINWDFYSMSIVSNGFESGNVYVWSV 341 Score = 57.8 bits (138), Expect = 7e-09, Method: Composition-based stats. Identities = 34/219 (15%), Positives = 68/219 (31%), Gaps = 57/219 (26%) Query: 153 CVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTN----HIGHTGYLNTVTVSPDGSLCA 208 C++FSP + + + ++++ + H + ++ SPDG L Sbjct: 30 CLQFSPCGD--YLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLL 87 Query: 209 SGGKDGQAMLWDLNE-GKHLYTLDGGDIINALCFSPNRYWLCAAT---GPSIKIWDLEGK 264 + +D LWDL++ K L + I + + LC AT + D Sbjct: 88 TSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSND 147 Query: 265 II------------------------------------------VDELKQEVISTSSKAE 282 + +D K + + Sbjct: 148 PVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIH 207 Query: 283 PPQCTS-----LAWSADGQTLFAGYTDNLVRVWQVTIGT 316 + TS L S +G+ L +D +R ++++I Sbjct: 208 SLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDD 246 Score = 55.5 bits (132), Expect = 3e-08, Method: Composition-based stats. Identities = 21/94 (22%), Positives = 40/94 (42%), Gaps = 6/94 (6%) Query: 225 KHLYTLDGGDIINALCFSPNRYWLC-AATGPSIKIWDLEGKIIVDELKQEVISTSSKAEP 283 K +T++ L FSP +L ++ I+D++ + V A Sbjct: 17 KLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPIC-----VPGNMLGAHV 71 Query: 284 PQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGTR 317 TS+AWS DG+ L D +++W ++ ++ Sbjct: 72 RPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSK 105 >2P9P-C nrPDB Length = 372 Score = 85.5 bits (210), Expect = 3e-17, Method: Composition-based stats. Identities = 39/265 (14%), Positives = 90/265 (33%), Gaps = 34/265 (12%) Query: 64 HFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTT--TRRFVGHTKDVLSVAFSSDNRQIV 121 +S + D + + +++ + H V V ++ D+ +IV Sbjct: 9 EPISCHAWNKDRTQIAICPNNHEVHIYEKSGNKWVQVHELKEHNGQVTGVDWAPDSNRIV 68 Query: 122 SGSRDKTIKLWNTLG-VCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLA 180 + D+ +W G K T+ + CVR++PN + S + + Sbjct: 69 TCGTDRNAYVWTLKGRTWKPTLVILRINRAARCVRWAPNEKKFAVGSGSRVISICYFEQE 128 Query: 181 NCKLKTNHIGHT--GYLNTVTVSPDGSLCASGGKDGQAMLW------------------D 220 N HI + ++ P+ L A+G D + ++ Sbjct: 129 NDWWVCKHIKKPIRSTVLSLDWHPNSVLLAAGSCDFKCRIFSAYIKEVEERPAPTPWGSK 188 Query: 221 LNEGKHLYTLDGG-DIINALCFSPNRYWLC-AATGPSIKIWDLEGKIIVDELKQEVISTS 278 + G+ ++ ++ +CFS N + + ++ + D + K+ V L E + Sbjct: 189 MPFGELMFESSSSCGWVHGVCFSANGSRVAWVSHDSTVCLADADKKMAVATLASETLP-- 246 Query: 279 SKAEPPQCTSLAWSADGQTLFAGYT 303 ++ + + + AG+ Sbjct: 247 -------LLAVTFITESSLVAAGHD 264 Score = 77.8 bits (190), Expect = 5e-15, Method: Composition-based stats. Identities = 39/267 (14%), Positives = 85/267 (31%), Gaps = 42/267 (15%) Query: 17 WVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQ 76 ++ A I + + +++ + N + L+ H+ V+ V + D Sbjct: 10 PISCHAWNKDRT-QIAICPNNHEVHIYEKS---GNKWVQVHELKEHNGQVTGVDWAPDSN 65 Query: 77 FALSGSWDGTLRLWDL--TTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKL--- 131 ++ D +W L T T + + V ++ + ++ GS + I + Sbjct: 66 RIVTCGTDRNAYVWTLKGRTWKPTLVILRINRAARCVRWAPNEKKFAVGSGSRVISICYF 125 Query: 132 ------WNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNL------ 179 W + K V + + PNS ++ + D ++++ Sbjct: 126 EQENDWWVCKHIKKPI------RSTVLSLDWHPNS--VLLAAGSCDFKCRIFSAYIKEVE 177 Query: 180 ------------ANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHL 227 +L G+++ V S +GS A D L D ++ + Sbjct: 178 ERPAPTPWGSKMPFGELMFESSSSCGWVHGVCFSANGSRVAWVSHDSTVCLADADKKMAV 237 Query: 228 YTLDGGD-IINALCFSPNRYWLCAATG 253 TL + A+ F + A Sbjct: 238 ATLASETLPLLAVTFITESSLVAAGHD 264 Score = 76.3 bits (186), Expect = 2e-14, Method: Composition-based stats. Identities = 39/221 (17%), Positives = 73/221 (33%), Gaps = 27/221 (12%) Query: 11 LKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVV 70 LK HNG VT + P + I++ D+ +W L + + + V Sbjct: 48 LKEHNGQVTGVDWAPD-SNRIVTCGTDRNAYVWTLKGRTWKPTLVILRI---NRAARCVR 103 Query: 71 ISSDGQFALSGSWDGTLRL--WDLTTG--TTTRRFVGHTKDVLSVAFSSDNRQIVSGSRD 126 + + + GS + + ++ VLS+ + ++ + +GS D Sbjct: 104 WAPNEKKFAVGSGSRVISICYFEQENDWWVCKHIKKPIRSTVLSLDWHPNSVLLAAGSCD 163 Query: 127 KTIKLWNT-----------------LGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCG 169 ++++ + + + S WV V FS N S + Sbjct: 164 FKCRIFSAYIKEVEERPAPTPWGSKMPFGELMFESSSSCGWVHGVCFSANGSR--VAWVS 221 Query: 170 WDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASG 210 D V + + T L VT + SL A+G Sbjct: 222 HDSTVCLADADKKMAVATLASETLPLLAVTFITESSLVAAG 262 Score = 71.3 bits (173), Expect = 6e-13, Method: Composition-based stats. Identities = 35/167 (20%), Positives = 55/167 (32%), Gaps = 11/167 (6%) Query: 149 EWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHI--GHTGYLNTVTVSPDGSL 206 E +SC + N I C + V ++ + K H H G + V +PD + Sbjct: 9 EPISCHAW--NKDRTQIAICPNNHEVHIYEKSGNKWVQVHELKEHNGQVTGVDWAPDSNR 66 Query: 207 CASGGKDGQAMLW--DLNEGKH-LYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEG 263 + G D A +W K L L + ++PN +G + + Sbjct: 67 IVTCGTDRNAYVWTLKGRTWKPTLVILRINRAARCVRWAPNEKKFAVGSGSRV----ISI 122 Query: 264 KIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVW 310 E V K SL W + L AG D R++ Sbjct: 123 CYFEQENDWWVCKHIKKPIRSTVLSLDWHPNSVLLAAGSCDFKCRIF 169 Score = 71.3 bits (173), Expect = 6e-13, Method: Composition-based stats. Identities = 35/226 (15%), Positives = 73/226 (32%), Gaps = 20/226 (8%) Query: 107 DVLSVAFSSDNRQIVSGSRDKTIKLWNTLG-VCKYTVQDESHSEWVSCVRFSPNSSNPII 165 + A++ D QI + + ++ G + + H+ V+ V ++P+S+ I Sbjct: 10 PISCHAWNKDRTQIAICPNNHEVHIYEKSGNKWVQVHELKEHNGQVTGVDWAPDSNR--I 67 Query: 166 VSCGWDKLVKVWNLANCKLKTNH--IGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNE 223 V+CG D+ VW L K + V +P+ A G + + Sbjct: 68 VTCGTDRNAYVWTLKGRTWKPTLVILRINRAARCVRWAPNEKKFAVGSGSRVISICYFEQ 127 Query: 224 GKHLYTLDG-----GDIINALCFSPNRYWLCAAT-GPSIKIWDLEGKIIVDELKQEVIST 277 + + +L + PN L A + +I+ K + + + Sbjct: 128 ENDWWVCKHIKKPIRSTVLSLDWHPNSVLLAAGSCDFKCRIFSAYIKEVEERPAPTPWGS 187 Query: 278 SSKAEP---------PQCTSLAWSADGQTLFAGYTDNLVRVWQVTI 314 + +SA+G + D+ V + Sbjct: 188 KMPFGELMFESSSSCGWVHGVCFSANGSRVAWVSHDSTVCLADADK 233 Score = 42.8 bits (99), Expect = 2e-04, Method: Composition-based stats. Identities = 14/81 (17%), Positives = 28/81 (34%), Gaps = 8/81 (9%) Query: 234 DIINALCFSPNRYWLC-AATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWS 292 + I+ ++ +R + + I++ G V + K Q T + W+ Sbjct: 9 EPISCHAWNKDRTQIAICPNNHEVHIYEKSGNKWVQVHE-------LKEHNGQVTGVDWA 61 Query: 293 ADGQTLFAGYTDNLVRVWQVT 313 D + TD VW + Sbjct: 62 PDSNRIVTCGTDRNAYVWTLK 82 >3I2N-A nrPDB Length = 357 Score = 79.4 bits (194), Expect = 2e-15, Method: Composition-based stats. Identities = 44/273 (16%), Positives = 87/273 (31%), Gaps = 36/273 (13%) Query: 72 SSDGQFALSGSWDGTLRLWDLTTGT-TTRRFVGHTKDVLSVAFSSDNRQ------IVSGS 124 S ++ +G + G L +W+L GH + + ++ IV+GS Sbjct: 77 SLQQRYLATGDFGGNLHIWNLEAPEMPVYSVKGHKEIINAIDGIGGLGIGEGAPEIVTGS 136 Query: 125 RDKTIKLWNTLGVCKYTVQDE------SHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWN 178 RD T+K+W+ E W + N ++ + + +K+++ Sbjct: 137 RDGTVKVWDPRQKDDPVANMEPVQGENKRDCWTVAFGNAYNQEERVVCAGYDNGDIKLFD 196 Query: 179 LANCKLKTNHIGHTGYLNTVTVSPD---GSLCASGGKDGQAMLWDLNEGKHLYTL----- 230 L N L+ + ++ + + +G+ ++D+ Sbjct: 197 LRNMALRWE-TNIKNGVCSLEFDRKDISMNKLVATSLEGKFHVFDMRTQHPTKGFASVSE 255 Query: 231 -DGGDIINALCFSPN--RYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQ-- 285 + + P +L A + +W E I + E I Sbjct: 256 KAHKSTVWQVRHLPQNRELFLTAGGAGGLHLWKYEYPIQRSKKDSEGIEMGVAGSVSLLQ 315 Query: 286 --------CTSLAWSADGQTLFAGYT-DNLVRV 309 +SL WS D + L + D VRV Sbjct: 316 NVTLSTQPISSLDWSPDKRGLCVCSSFDQTVRV 348 Score = 72.8 bits (177), Expect = 2e-13, Method: Composition-based stats. Identities = 39/245 (15%), Positives = 81/245 (33%), Gaps = 38/245 (15%) Query: 10 TLKGHNGWVTQIATTPQFPDM-----ILSASRDKTIIMWKLTRDETNYGIPQRALRGHSH 64 ++KGH + I I++ SRD T+ +W + + + + Sbjct: 106 SVKGHKEIINAIDGIGGLGIGEGAPEIVTGSRDGTVKVWDPRQKDDPVANMEPVQGENKR 165 Query: 65 FVSDVVIS---SDGQFALSGSWD-GTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDN--- 117 V + + + +D G ++L+DL R V S+ F + Sbjct: 166 DCWTVAFGNAYNQEERVVCAGYDNGDIKLFDLRNMA-LRWETNIKNGVCSLEFDRKDISM 224 Query: 118 RQIVSGSRDKTIKLWNTLGVCKY----TVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKL 173 ++V+ S + +++ +V +++H V VR P + + + G Sbjct: 225 NKLVATSLEGKFHVFDMRTQHPTKGFASVSEKAHKSTVWQVRHLPQNRELFLTAGGA-GG 283 Query: 174 VKVWN-------------------LANCKLKTNHIGHTGYLNTVTVSPDGS-LCASGGKD 213 + +W + L N T ++++ SPD LC D Sbjct: 284 LHLWKYEYPIQRSKKDSEGIEMGVAGSVSLLQNVTLSTQPISSLDWSPDKRGLCVCSSFD 343 Query: 214 GQAML 218 + Sbjct: 344 QTVRV 348 Score = 47.0 bits (110), Expect = 9e-06, Method: Composition-based stats. Identities = 28/188 (14%), Positives = 68/188 (36%), Gaps = 27/188 (14%) Query: 148 SEWVSCVRFSPNSSNPIIVSCGW----DKLVKVWNLANCKLKT-NHIGHTGYLNTVTV-- 200 + V ++ P S+ V+ G +++++ + + LK I + T Sbjct: 18 NYTVFDCKWVPCSAK--FVTMGNFARGTGVIQLYEIQHGDLKLLREIEKAKPIKCGTFGA 75 Query: 201 -SPDGSLCASGGKDGQAMLWDLNE-GKHLYTLDGGDIINALCFSPNR--------YWLCA 250 S A+G G +W+L +Y++ G I + Sbjct: 76 TSLQQRYLATGDFGGNLHIWNLEAPEMPVYSVKGHKEIINAIDGIGGLGIGEGAPEIVTG 135 Query: 251 ATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAW----SADGQTLFAGYTDNL 306 + ++K+WD K + V + + C ++A+ + + + + AGY + Sbjct: 136 SRDGTVKVWDPRQKDDPVANMEPVQGENKR----DCWTVAFGNAYNQEERVVCAGYDNGD 191 Query: 307 VRVWQVTI 314 ++++ + Sbjct: 192 IKLFDLRN 199 >6CHG-D nrPDB Length = 439 Score = 79.4 bits (194), Expect = 2e-15, Method: Composition-based stats. Identities = 52/285 (18%), Positives = 91/285 (31%), Gaps = 41/285 (14%) Query: 68 DVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFV----GHTKDVLSVAFSSDNRQIVSG 123 V S G + G +G + ++D+ + HT+ V SV +S+D R + S Sbjct: 32 CVKFSPRGDYLAVGCSNGAIIIYDMDSLKPIAMLGTHSGAHTRSVQSVCWSNDGRYLWSS 91 Query: 124 SRDKTIKLWNTL--GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLAN 181 RD KLW+ C + + VR+ N IV+ + V L + Sbjct: 92 GRDWYAKLWDMTQPTKCFQQYKFDGPLWSCHVVRW-----NVCIVTVVEEPTAYVLTLTD 146 Query: 182 CK----------LKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLW--DLNEG----- 224 + + GH L S+ +G G + DL G Sbjct: 147 RQNAFHCFPLLEQDQDISGHGYTLVACPHPTIESIIITGTSKGWINAFQLDLESGFEDKI 206 Query: 225 -KHLYTLDGGDIINALCFSPNRYWLC-AATGPSIKIWDL--EGKIIVDELKQEVISTSSK 280 I + SP+ + + +I+ + L E V Sbjct: 207 RCCYEEKIANANIKQIIISPSGTRIAINGSDRTIRQYQLIVEDNESEGGSSHSVSIELEH 266 Query: 281 AEPPQCTSLAWSA------DGQTLFA---GYTDNLVRVWQVTIGT 316 L W+ G+ L A G + + + +W+ + G+ Sbjct: 267 KYQDIINRLQWNTIFFSNHSGEYLVASAHGSSAHDLYLWETSSGS 311 Score = 74.3 bits (181), Expect = 6e-14, Method: Composition-based stats. Identities = 51/340 (15%), Positives = 106/340 (31%), Gaps = 52/340 (15%) Query: 14 HNGWV----TQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDV 69 H V + +P+ D + + II++ + + + + H+ V V Sbjct: 22 HTLEVPVAAVCVKFSPR-GDYLAVGCSNGAIIIYDMDSLKPIAMLGTHS-GAHTRSVQSV 79 Query: 70 VISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTI 129 S+DG++ S D +LWD+T T + + S N IV+ + T Sbjct: 80 CWSNDGRYLWSSGRDWYAKLWDMTQPTKCFQQYKFDGPLWSCHVVRWNVCIVTVVEEPTA 139 Query: 130 KLWNTLGVCKYTV-------QDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVW--NLA 180 + + + V + II++ + + +L Sbjct: 140 YVLTLTDRQNAFHCFPLLEQDQDISGHGYTLVACPHPTIESIIITGTSKGWINAFQLDLE 199 Query: 181 NC-----KLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDL----------NEGK 225 + + + + +SP G+ A G D + L + Sbjct: 200 SGFEDKIRCCYEEKIANANIKQIIISPSGTRIAINGSDRTIRQYQLIVEDNESEGGSSHS 259 Query: 226 HLYTLDG--GDIINALCF-------SPNRYWLCAATG---PSIKIWDLEGKIIVDELKQE 273 L+ DIIN L + Y + +A G + +W+ +V L+ Sbjct: 260 VSIELEHKYQDIINRLQWNTIFFSNHSGEYLVASAHGSSAHDLYLWETSSGSLVRVLE-- 317 Query: 274 VISTSSKAEPPQCTSLAWSADGQTLFA-GYTDNLVRVWQV 312 + + W+ + + G+ V +W + Sbjct: 318 -------GADEELLDIDWNFYSMRIASNGFESGWVYMWSI 350 Score = 55.1 bits (131), Expect = 4e-08, Method: Composition-based stats. Identities = 23/94 (24%), Positives = 42/94 (44%), Gaps = 6/94 (6%) Query: 225 KHLYTLDGGDIINALCFSPNR-YWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEP 283 K +TL+ + FSP Y + +I I+D++ + ++ T S A Sbjct: 19 KLTHTLEVPVAAVCVKFSPRGDYLAVGCSNGAIIIYDMDSLKPIA-----MLGTHSGAHT 73 Query: 284 PQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGTR 317 S+ WS DG+ L++ D ++W +T T+ Sbjct: 74 RSVQSVCWSNDGRYLWSSGRDWYAKLWDMTQPTK 107 >5MC6-j nrPDB Length = 397 Score = 77.4 bits (189), Expect = 8e-15, Method: Composition-based stats. Identities = 56/331 (16%), Positives = 115/331 (34%), Gaps = 43/331 (12%) Query: 12 KGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTR-DETNYGIPQRALRGHSHFVSDVV 70 K H+ + ++ F +S S D + +W D N + H + V Sbjct: 13 KAHDADIFSVSACNSFT---VSCSGDGYLKVWDNKLLDNENPKDKSYSHFVHKSGLHHVD 69 Query: 71 ISS-------DGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIV-- 121 + + + S+ G L + +T T++ + D+L + + Sbjct: 70 VLQAIERDAFELCLVATTSFSGDLLFYRITREDETKKVIFEKLDLLDSDMKKHSFWALKW 129 Query: 122 SGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLAN 181 S D+ + K T +F P + ++ W +++ Sbjct: 130 GASNDRLLSHRLVATDVKGTT---------YIWKFHPFADESNSLTLNWSPTLEL----- 175 Query: 182 CKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGG-------D 234 + + + + +V +S G L A+G +G + +L+ + LY + + Sbjct: 176 QGTVESPMTPSQFATSVDISERG-LIATGFNNGTVQISELSTLRPLYNFESQHSMINNSN 234 Query: 235 IINALCFSPNRYWLCAATGPS----IKIWDLEGKIIVDELKQEVISTSSK----AEPPQC 286 I ++ FSP L A + I +++ E + L S+ + A Sbjct: 235 SIRSVKFSPQGSLLAIAHDSNSFGCITLYETEFGERIGSLSVPTHSSQASLGEFAHSSWV 294 Query: 287 TSLAWSADGQTLFAGYTDNLVRVWQVTIGTR 317 SL+++ G+TL + D +R W V R Sbjct: 295 MSLSFNDSGETLCSAGWDGKLRFWDVKTKER 325 Score = 64.3 bits (155), Expect = 7e-11, Method: Composition-based stats. Identities = 38/203 (18%), Positives = 72/203 (35%), Gaps = 37/203 (18%) Query: 28 PDMILSASRDKTIIMWKL------TRDETNYGIPQRALRG-------HSHFVSDVVISSD 74 +++ T +WK + T P L+G S F + V IS Sbjct: 138 SHRLVATDVKGTTYIWKFHPFADESNSLTLNWSPTLELQGTVESPMTPSQFATSVDISER 197 Query: 75 GQFALSGSWDGTLRLWDL------TTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKT 128 G +G +GT+++ +L + + ++ + SV FS + + Sbjct: 198 G-LIATGFNNGTVQISELSTLRPLYNFESQHSMINNSNSIRSVKFSPQGSLLAIAHDSNS 256 Query: 129 ---IKLWNT------------LGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKL 173 I L+ T + ++ + +HS WV + F N S + S GWD Sbjct: 257 FGCITLYETEFGERIGSLSVPTHSSQASLGEFAHSSWVMSLSF--NDSGETLCSAGWDGK 314 Query: 174 VKVWNLANCKLKTNHIGHTGYLN 196 ++ W++ + T H + Sbjct: 315 LRFWDVKTKERITTLNMHCDDIE 337 Score = 53.5 bits (127), Expect = 1e-07, Method: Composition-based stats. Identities = 20/105 (19%), Positives = 37/105 (35%), Gaps = 12/105 (11%) Query: 15 NGWVTQIATTPQFPDMILSASRDKT---IIMWKLTRDETNYGIPQRAL--------RGHS 63 + + + +PQ ++ A + I +++ E + HS Sbjct: 233 SNSIRSVKFSPQ-GSLLAIAHDSNSFGCITLYETEFGERIGSLSVPTHSSQASLGEFAHS 291 Query: 64 HFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDV 108 +V + + G+ S WDG LR WD+ T H D+ Sbjct: 292 SWVMSLSFNDSGETLCSAGWDGKLRFWDVKTKERITTLNMHCDDI 336 >5WLC-LW nrPDB Length = 554 Score = 72.8 bits (177), Expect = 2e-13, Method: Composition-based stats. Identities = 35/243 (14%), Positives = 83/243 (34%), Gaps = 17/243 (6%) Query: 19 TQIATTPQFPDMILSASRDKTIIM-WKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQF 77 I ++++ + M W+ + + + HS + Q+ Sbjct: 114 YHIKYAKNGTHLLITGRKGHVASMDWRKGQLRAELFLNETC---HSA-----TYLQNEQY 165 Query: 78 ALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGV 137 T ++D GT R H + + F + +V+ +K + Sbjct: 166 FAVAQKKYTF-IYD-HEGTELHRLKQHI-EARHLDFLPYHYLLVTAGETGWLKYHDVSTG 222 Query: 138 CKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNT 197 + E ++ + + N N ++ + V +W+ + + + G +N+ Sbjct: 223 QLVS---ELRTKAGPTMAMAQNPWNAVMHLGHSNGTVSLWSPSMPEPLVKLLSARGPVNS 279 Query: 198 VTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG-GDIINALCFSPNRYWLCAATGPSI 256 + + G A+ G D +WD+ K L++++ + S L + GP + Sbjct: 280 IAIDRSGYYMATTGADRSMKIWDIRNFKQLHSVESLPTPGTNVSISDTG-LLALSRGPHV 338 Query: 257 KIW 259 +W Sbjct: 339 TLW 341 Score = 59.3 bits (142), Expect = 2e-09, Method: Composition-based stats. Identities = 25/226 (11%), Positives = 64/226 (28%), Gaps = 18/226 (7%) Query: 91 DLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEW 150 D++T + ++ + ++ R + + + + + Sbjct: 96 DVSTANKALDLSLKEFGPYHIKYAKNGTHLLITGRKGHVASMDWR-KGQLRAELFLNE-- 152 Query: 151 VSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASG 210 + N + K +++ H + + P L + Sbjct: 153 --TCHSATYLQNEQYFAVAQKKYTFIYD-HEGTELHRLKQHIEARH-LDFLPYHYLLVTA 208 Query: 211 GKDGQAMLWDLNEGKHLYTLDG-GDIINALCFSP-NRYWLCAATGPSIKIWDLEGKIIVD 268 G+ G D++ G+ + L A+ +P N + ++ +W Sbjct: 209 GETGWLKYHDVSTGQLVSELRTKAGPTMAMAQNPWNAVMHLGHSNGTVSLWS-------- 260 Query: 269 ELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTI 314 E + A P S+A G + D +++W + Sbjct: 261 PSMPEPLVKLLSARGP-VNSIAIDRSGYYMATTGADRSMKIWDIRN 305 Score = 58.6 bits (140), Expect = 4e-09, Method: Composition-based stats. Identities = 36/247 (14%), Positives = 86/247 (34%), Gaps = 20/247 (8%) Query: 67 SDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRD 126 + + +G L G + D G + S + + + + Sbjct: 114 YHIKYAKNGTHLLITGRKGHVASMDWRKGQLRAELFL-NETCHSATYLQNEQYFAVA-QK 171 Query: 127 KTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKT 186 K +++ G + ++ + + F P + ++V+ G +K +++ +L + Sbjct: 172 KYTFIYDHEGTELHRLKQHIEA---RHLDFLPY--HYLLVTAGETGWLKYHDVSTGQLVS 226 Query: 187 NHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTL-DGGDIINALCFSPNR 245 G + +P ++ G +G LW + + L L +N++ + Sbjct: 227 ELRTKAGPTMAMAQNPWNAVMHLGHSNGTVSLWSPSMPEPLVKLLSARGPVNSIAIDRSG 286 Query: 246 YWLCA-ATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTD 304 Y++ S+KIWD+ + ++ T+++ S G L A Sbjct: 287 YYMATTGADRSMKIWDIRNFKQLHSVESLPTPG---------TNVSISDTG--LLALSRG 335 Query: 305 NLVRVWQ 311 V +W+ Sbjct: 336 PHVTLWK 342 Score = 37.4 bits (85), Expect = 0.009, Method: Composition-based stats. Identities = 19/119 (15%), Positives = 39/119 (32%), Gaps = 11/119 (9%) Query: 197 TVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATGPSI 256 + + +G+ G+ G D +G+ L + ++ + N + A Sbjct: 115 HIKYAKNGTHLLITGRKGHVASMDWRKGQLRAELFLNETCHSATYLQNEQYFAVAQKKYT 174 Query: 257 KIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIG 315 I+D EG + LKQ + + L + L ++ V+ G Sbjct: 175 FIYDHEGTEL-HRLKQHI----------EARHLDFLPYHYLLVTAGETGWLKYHDVSTG 222 >5TF2-A nrPDB Length = 407 Score = 72.0 bits (175), Expect = 3e-13, Method: Composition-based stats. Identities = 36/231 (15%), Positives = 73/231 (31%), Gaps = 34/231 (14%) Query: 69 VVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKT 128 V + D +G DG +R+W + + F H ++ +A D + +V+ RD Sbjct: 178 VCFNHDNTLLATGGTDGYVRVWKVPSLEKVLEFKAHEGEIEDLALGPDGK-LVTVGRDLK 236 Query: 129 IKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDK-------LVKV----- 176 +W V E +P D+ V++ Sbjct: 237 ASVW----QKDQLVTQLHWQENGPTFSSTPYRYQACRFGQVPDQPAGLRLFTVQIPHKRL 292 Query: 177 ----------WNLANCKLKTNHI-GHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGK 225 W+ +N GH ++ + VS G+ G G ++ + Sbjct: 293 RQPPPCYLTAWDGSNFLPLRTKSCGHEV-VSCLDVSESGTFLGLGTVTGSVAIYIAFSLQ 351 Query: 226 HLYTLD--GGDIINALCFSPN---RYWLCAATGPSIKIWDLEGKIIVDELK 271 LY + G ++ + F P L + ++ ++ + + L Sbjct: 352 CLYYVREAHGIVVTDVAFLPEKGRGPELLGSHETALFSVAVDSRCQLHLLP 402 Score = 52.8 bits (125), Expect = 2e-07, Method: Composition-based stats. Identities = 20/128 (15%), Positives = 42/128 (32%), Gaps = 8/128 (6%) Query: 179 LANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGD-IIN 237 + N + V + D +L A+GG DG +W + + + + I Sbjct: 159 VENLQAVQTDFSSDPLQKVVCFNHDNTLLATGGTDGYVRVWKVPSLEKVLEFKAHEGEIE 218 Query: 238 ALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAW-----S 292 L P+ + +W + +V +L + + + P + + + Sbjct: 219 DLALGPDGKLVTVGRDLKASVW--QKDQLVTQLHWQENGPTFSSTPYRYQACRFGQVPDQ 276 Query: 293 ADGQTLFA 300 G LF Sbjct: 277 PAGLRLFT 284 Score = 38.1 bits (87), Expect = 0.006, Method: Composition-based stats. Identities = 18/76 (23%), Positives = 27/76 (35%), Gaps = 11/76 (14%) Query: 237 NALCFSPNRYWLC-AATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADG 295 +CF+ + L T +++W + V E K A + LA DG Sbjct: 176 KVVCFNHDNTLLATGGTDGYVRVWKVPSLEKVLEFK---------AHEGEIEDLALGPDG 226 Query: 296 QTLFAGYTDNLVRVWQ 311 + L D VWQ Sbjct: 227 K-LVTVGRDLKASVWQ 241 Score = 37.0 bits (84), Expect = 0.013, Method: Composition-based stats. Identities = 10/24 (41%), Positives = 14/24 (58%) Query: 289 LAWSADGQTLFAGYTDNLVRVWQV 312 + ++ D L G TD VRVW+V Sbjct: 178 VCFNHDNTLLATGGTDGYVRVWKV 201 >5AJA-A nrPDB Length = 361 Score = 71.6 bits (174), Expect = 4e-13, Method: Composition-based stats. Identities = 41/232 (17%), Positives = 81/232 (34%), Gaps = 23/232 (9%) Query: 67 SDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGS-- 124 + S+ +F + G+ G L+L+++ +G + H + + S D +++ + Sbjct: 41 TCCAFSARERFLMLGTCTGQLKLYNVFSGQEEASYNCHNSAITHLEPSRDGSLLLTSATW 100 Query: 125 RDKTIKLWNTLGVCKYTVQDESHS-EWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCK 183 LW +V D HS V FS +S + +I + G + ++++ Sbjct: 101 SQPLSALW-----GMKSVFDMKHSFTEDHYVEFSKHSQDRVIGTKGD--IAHIYDIQTGN 153 Query: 184 LKTNHIG----HTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINAL 239 + N T +P L DG LWD+ + ++ D ++ + Sbjct: 154 KLLTLFNPDLANNYKRNCATFNPTDDLVL---NDGV--LWDVRSAQAIHKFDKFNMNISG 208 Query: 240 CFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAW 291 F PN + T IWDL ++ + A Sbjct: 209 VFHPNGLEVIINTE----IWDLRTFHLLHTVPALDQCRVVFNHTGTVMYGAM 256 Score = 46.6 bits (109), Expect = 1e-05, Method: Composition-based stats. Identities = 31/198 (15%), Positives = 71/198 (35%), Gaps = 22/198 (11%) Query: 123 GSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANC 182 G D+ + +++ + +C FS ++ +C +K++N+ + Sbjct: 13 GCFDRHL-IFSRFRPISVFREANEDESGFTCCAFSARERFLMLGTCT--GQLKLYNVFSG 69 Query: 183 KLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAM--LWDLNE---GKHLYTLDGGDIIN 237 + + ++ H + + S DGSL + Q + LW + KH +T D + Sbjct: 70 QEEASYNCHNSAITHLEPSRDGSLLLTSATWSQPLSALWGMKSVFDMKHSFTEDHYVEFS 129 Query: 238 ALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQT 297 S +R + G I+D++ + L ++ + K ++ Sbjct: 130 --KHSQDR--VIGTKGDIAHIYDIQTGNKLLTLFNPDLANNYKR-----NCATFNPTDDL 180 Query: 298 LFAGYTDNLVRVWQVTIG 315 + D + +W V Sbjct: 181 VL---NDGV--LWDVRSA 193 Score = 45.5 bits (106), Expect = 3e-05, Method: Composition-based stats. Identities = 35/238 (14%), Positives = 83/238 (34%), Gaps = 28/238 (11%) Query: 19 TQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFA 78 T A + + ++L + + ++ + + + H+ ++ + S DG Sbjct: 41 TCCAFSARERFLML-GTCTGQLKLYNVFSGQEE-----ASYNCHNSAITHLEPSRDGSLL 94 Query: 79 L-SGSWDGTLR-LWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLG 136 L S +W L LW + + + V FS ++ V G++ +++ Sbjct: 95 LTSATWSQPLSALWGMKSVFDMKHSFTEDHYVE---FSKHSQDRVIGTKGDIAHIYDIQT 151 Query: 137 VCKYTVQDE---SHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTG 193 K +++ +C F+P + D + +W++ + + Sbjct: 152 GNKLLTLFNPDLANNYKRNCATFNPTDDLVL-----NDGV--LWDVRSAQAIHKFDKFNM 204 Query: 194 YLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAA 251 ++ V P+G + +WDL L+T+ D + F+ + A Sbjct: 205 NISGV-FHPNGLEVIINTE-----IWDLRTFHLLHTVPALDQ-CRVVFNHTGTVMYGA 255 >2I3T-A nrPDB Length = 341 Score = 68.2 bits (165), Expect = 5e-12, Method: Composition-based stats. Identities = 41/280 (14%), Positives = 94/280 (33%), Gaps = 24/280 (8%) Query: 60 RGHSHFVSDVVISSDGQFALSGSWDGTLRLW--DLTTGTT-TRRFVGHTKDVLSVAFSSD 116 + ++SD+ I L SWDG+L ++ D+ + + + +L F + Sbjct: 8 QAPKDYISDIKIIPSKSLLLITSWDGSLTVYKFDIQAKNVDLLQSLRYKHPLLCCNFIDN 67 Query: 117 NR-QIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVK 175 QI G+ I + +G + + + C R + +I + WD L++ Sbjct: 68 TDLQIYVGTVQGEILKVDLIGSPSFQALTNNEANLGIC-RICKYGDDKLIAA-SWDGLIE 125 Query: 176 VWNLANC----KLKTNHIGHTGYLNT--VTVSPDGSLCASGGKDGQAMLWDLN----EGK 225 V + N N + + T+ + S G + Q + L + Sbjct: 126 VIDPRNYGDGVIAVKNLNSNNTKVKNKIFTMDTNSSRLIVGMNNSQVQWFRLPLCEDDNG 185 Query: 226 HLYTLDGGDIINALCFSPNRY--WLCAATGPSIKI--WDLEGKIIVDE----LKQEVIST 277 + I + P + C++ + + +D +G + ++ Sbjct: 186 TIEESGLKYQIRDVALLPKEQEGYACSSIDGRVAVEFFDDQGDDYNSSKRFAFRCHRLNL 245 Query: 278 SSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGTR 317 S+ +S + L+ +D ++ W + + Sbjct: 246 KDTNLAYPVNSIEFSPRHKFLYTAGSDGIISCWNLQTRKK 285 Score = 50.8 bits (120), Expect = 7e-07, Method: Composition-based stats. Identities = 40/238 (16%), Positives = 77/238 (32%), Gaps = 40/238 (16%) Query: 45 LTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGT----TTRR 100 LT +E N GI + G ++ SWDG + + D + Sbjct: 95 LTNNEANLGICRICKYGDDK-------------LIAASWDGLIEVIDPRNYGDGVIAVKN 141 Query: 101 FVGHTKDVLSVAFSSD--NRQIVSGSRDKTIKLWNTLGVC---KYTVQDESHSEWVSCVR 155 + V + F+ D + +++ G + + W L +C T+++ + V Sbjct: 142 LNSNNTKVKNKIFTMDTNSSRLIVGMNNSQV-QWFRLPLCEDDNGTIEESGLKYQIRDVA 200 Query: 156 FSPNSSNPIIVSCGWDKLVKV--WNLA----NCKLKTNHIGHTG---------YLNTVTV 200 P D V V ++ N + H +N++ Sbjct: 201 LLPKEQEGY-ACSSIDGRVAVEFFDDQGDDYNSSKRFAFRCHRLNLKDTNLAYPVNSIEF 259 Query: 201 SPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLC-AATGPSIK 257 SP + G DG W+L K + + + + + + LC A + + K Sbjct: 260 SPRHKFLYTAGSDGIISCWNLQTRKKIKNFAKFNEDSVVKIACSDNILCLATSDDTFK 317 Score = 47.0 bits (110), Expect = 1e-05, Method: Composition-based stats. Identities = 26/150 (17%), Positives = 55/150 (36%), Gaps = 16/150 (10%) Query: 13 GHNGWVTQIATTPQFPDMILSASRDKTIIM--WKLTRDETNYGIPQRALRGHS------- 63 G + +A P+ + +S D + + + D+ N + A R H Sbjct: 191 GLKYQIRDVALLPKEQEGYACSSIDGRVAVEFFDDQGDDYNSSK-RFAFRCHRLNLKDTN 249 Query: 64 --HFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIV 121 + V+ + S +F + DG + W+L T + F +D V + + + Sbjct: 250 LAYPVNSIEFSPRHKFLYTAGSDGIISCWNLQTRKKIKNFAKFNED-SVVKIACSDNILC 308 Query: 122 SGSRDKTIKLWNTLGVCKYTVQDESHSEWV 151 + D T + T T++ + S ++ Sbjct: 309 LATSDDT---FKTNAAIDQTIELNASSIYI 335 >3DWL-C nrPDB Length = 377 Score = 67.0 bits (162), Expect = 1e-11, Method: Composition-based stats. Identities = 42/252 (16%), Positives = 81/252 (32%), Gaps = 50/252 (19%) Query: 70 VISSDGQFALSGSWDGTLRLW--DLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDK 127 +S ++ + + L+ D R F H K V V ++ + +IV+ S+D+ Sbjct: 18 AFNSQRTEFVTTTATNQVELYEQDGNGWKHARTFSDHDKIVTCVDWAPKSNRIVTCSQDR 77 Query: 128 TIKLWNTL--GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLK 185 ++ G K T+ + + VR+SPN + S V + N Sbjct: 78 NAYVYEKRPDGTWKQTLVLLRLNRAATFVRWSPNEDKFAVGSGARVISVCYFEQENDWWV 137 Query: 186 TNHIGHT--GYLNTVTVSPDGSLCASGGKDGQ-----AMLWDLNEGKHLYTLDGGDIINA 238 + H+ + ++ P+ L A+G D + A + D++ N Sbjct: 138 SKHLKRPLRSTILSLDWHPNNVLLAAGCADRKAYVLSAYVRDVDAKPEASVWGSRLPFNT 197 Query: 239 LCF-SPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQT 297 +C P+ W+ A + +S G Sbjct: 198 VCAEYPSGGWVHA--------------------------------------VGFSPSGNA 219 Query: 298 LFAGYTDNLVRV 309 L D+ V + Sbjct: 220 LAYAGHDSSVTI 231 Score = 66.3 bits (160), Expect = 2e-11, Method: Composition-based stats. Identities = 36/230 (15%), Positives = 76/230 (33%), Gaps = 37/230 (16%) Query: 9 GTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSD 68 T H+ VT + P+ + I++ S+D+ +++ D L + + Sbjct: 49 RTFSDHDKIVTCVDWAPK-SNRIVTCSQDRNAYVYEKRPD--GTWKQTLVLLRLNRAATF 105 Query: 69 VVISSDGQFALSGSWDGTLRL--------WDLTTGTTTRRFVGHTKDVLSVAFSSDNRQI 120 V S + GS + + W + R +LS+ + +N + Sbjct: 106 VRWSPNEDKFAVGSGARVISVCYFEQENDW-WVSKHLKRPLR---STILSLDWHPNNVLL 161 Query: 121 VSGSRDKT----------------IKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPI 164 +G D+ +W + + WV V FSP+ + Sbjct: 162 AAGCADRKAYVLSAYVRDVDAKPEASVWGSRLPFNTVCAEYPSGGWVHAVGFSPSGNA-- 219 Query: 165 IVSCGWDKLVKV-WNLANCKLKTNHIGH---TGYLNTVTVSPDGSLCASG 210 + G D V + + A + I L ++ + + ++ A+G Sbjct: 220 LAYAGHDSSVTIAYPSAPEQPPRALITVKLSQLPLRSLLWANESAIVAAG 269 Score = 62.8 bits (151), Expect = 2e-10, Method: Composition-based stats. Identities = 42/267 (15%), Positives = 82/267 (30%), Gaps = 38/267 (14%) Query: 44 KLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLT---TGTTTRR 100 +L + N R H V+ V + ++ S D +++ T T Sbjct: 36 ELYEQDGNGWKHARTFSDHDKIVTCVDWAPKSNRIVTCSQDRNAYVYEKRPDGTWKQTLV 95 Query: 101 FVGHTKDVLSVAFSSDNRQIVSGSRDKTIKL--WNTLGVCKYTVQDESH-SEWVSCVRFS 157 + + V +S + + GS + I + + + + + + + Sbjct: 96 LLRLNRAATFVRWSPNEDKFAVGSGARVISVCYFEQENDWWVSKHLKRPLRSTILSLDWH 155 Query: 158 PNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAM 217 PN N ++ + D+ V + Y+ V P+ S+ S Sbjct: 156 PN--NVLLAAGCADRKAYVLSA--------------YVRDVDAKPEASVWGS-------- 191 Query: 218 LWDLNEGKHLYTLDGGDIINALCFSPNRYWLC-AATGPSIKIWDLEGKIIVDELKQEVIS 276 L G ++A+ FSP+ L A S+ I + Sbjct: 192 --RLPFNTVCAEYPSGGWVHAVGFSPSGNALAYAGHDSSVTI-----AYPSAPEQPPRAL 244 Query: 277 TSSKAEPPQCTSLAWSADGQTLFAGYT 303 + K SL W+ + + AGY Sbjct: 245 ITVKLSQLPLRSLLWANESAIVAAGYN 271 Score = 32.4 bits (72), Expect = 0.28, Method: Composition-based stats. Identities = 7/72 (9%), Positives = 20/72 (27%), Gaps = 6/72 (8%) Query: 240 CFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLF 299 F+ R T + + ++ + + + T + W+ + Sbjct: 18 AFNSQRTEFVTTTATN------QVELYEQDGNGWKHARTFSDHDKIVTCVDWAPKSNRIV 71 Query: 300 AGYTDNLVRVWQ 311 D V++ Sbjct: 72 TCSQDRNAYVYE 83 Score = 27.4 bits (59), Expect = 8.9, Method: Composition-based stats. Identities = 28/177 (15%), Positives = 58/177 (32%), Gaps = 18/177 (10%) Query: 16 GWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDG 75 GWV + +P + + A D ++ + ++ + ++ +++ Sbjct: 206 GWVHAVGFSPS-GNALAYAGHDSSVTI-AYPSAPEQPPRALITVKLSQLPLRSLLWANES 263 Query: 76 QFALSGSWDGTLRL------W----DLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSR 125 +G + L W DL GT+ F HT + + + R Sbjct: 264 AIVAAGYNYSPILLQGNESGWAHTRDLDAGTSKTSFT-HTGN-TGEGREEEGPVSFTALR 321 Query: 126 DKTIKLWNTLGVCKYTVQDES-HSEWVSCVRFSPNSSNPI--IVSCGWDKLVKVWNL 179 T + + G + + H ++ +R + I S G D V +W L Sbjct: 322 -STFRNMDLKGSSQSISSLPTVHQNMIATLRPYAGTPGNITAFTSSGTDGRVVLWTL 377 >5A9Q-0 nrPDB Length = 380 Score = 66.6 bits (161), Expect = 1e-11, Method: Composition-based stats. Identities = 26/172 (15%), Positives = 60/172 (34%), Gaps = 11/172 (6%) Query: 31 ILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLW 90 I++ D I +++ E R + V L+ + G L++W Sbjct: 144 IVTVGEDGRINLFRADHKE-----AVRTIDNADSSTLHAVTFLRTPEILTVNSIGQLKIW 198 Query: 91 DLTTGTT----TRRFVGHTKDVLSVAFSSDNRQIV-SGSRDKTIKLWNTLGVCKYTVQDE 145 D G + V + + +V +G +D + +W+ + Sbjct: 199 DFRQQGNEPSQILSLTGDRVPLHCVDRHPNQQHVVATGGQDGMLSIWDVRQGTMPVSLLK 258 Query: 146 SHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNT 197 +H + V F P++ + +C D + W+ + + + + H G ++ Sbjct: 259 AHEAEMWEVHFHPSNPE-HLFTCSEDGSLWHWDASTDVPEKSSLFHQGGRSS 309 Score = 64.7 bits (156), Expect = 5e-11, Method: Composition-based stats. Identities = 49/271 (18%), Positives = 88/271 (32%), Gaps = 43/271 (15%) Query: 78 ALSGSWDGT---LRLWDLTTGTTTRRFVG------------HTKDVLSVAFSSDNRQIVS 122 +GSWD + LW + G H DV+ + F D +IV+ Sbjct: 32 FATGSWDNEENYISLWSIGDFGNLDSDGGFEGDHQLLCDIRHHGDVMDLQF-FDQERIVA 90 Query: 123 GSRDKTIKLW------NTLGVCKYTVQDESHSEWVS-CVRFSPNS----SNPIIVSCGWD 171 S + ++ TL V + H+ S +P + +NP IV+ G D Sbjct: 91 ASSTGCVTVFLHHPNNQTLSVNQQWTTAHYHTGPGSPSYSSAPCTGVVCNNPEIVTVGED 150 Query: 172 KLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDL----NEGKHL 227 + ++ + + + GQ +WD NE + Sbjct: 151 GRINLFRADHKEAVRTIDNADSSTLHAVTFLRTPEILTVNSIGQLKIWDFRQQGNEPSQI 210 Query: 228 YTLDGG-DIINALCFSPNRYWLCAATGPS--IKIWDLEGKIIVDELKQEVISTSSKAEPP 284 +L G ++ + PN+ + A G + IWD+ + L KA Sbjct: 211 LSLTGDRVPLHCVDRHPNQQHVVATGGQDGMLSIWDVRQGTMPVSL--------LKAHEA 262 Query: 285 QCTSLAWSADG-QTLFAGYTDNLVRVWQVTI 314 + + + + LF D + W + Sbjct: 263 EMWEVHFHPSNPEHLFTCSEDGSLWHWDAST 293 Score = 58.6 bits (140), Expect = 3e-09, Method: Composition-based stats. Identities = 17/96 (17%), Positives = 38/96 (39%), Gaps = 5/96 (5%) Query: 10 TLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDV 69 +L G + + P ++ + +D + +W + + +P L+ H + +V Sbjct: 212 SLTGDRVPLHCVDRHPNQQHVVATGGQDGMLSIWDVRQGT----MPVSLLKAHEAEMWEV 267 Query: 70 VISSDG-QFALSGSWDGTLRLWDLTTGTTTRRFVGH 104 + + S DG+L WD +T + + H Sbjct: 268 HFHPSNPEHLFTCSEDGSLWHWDASTDVPEKSSLFH 303 >5LTD-A nrPDB Length = 525 Score = 66.3 bits (160), Expect = 2e-11, Method: Composition-based stats. Identities = 38/205 (18%), Positives = 77/205 (37%), Gaps = 33/205 (16%) Query: 93 TTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVS 152 T F G +L+V + + ++ ++TI +++ + + E+ S Sbjct: 109 QTTICELTFPG---AILAVKLNRERLVVL---LEETIYIYDINNM-RLLHTIETPSNPNG 161 Query: 153 CVRFSPNSSNPIIVSCGWDKL---------------------VKVWNLANCKLKTNHIGH 191 + SP+S N + KL V +++ + + H Sbjct: 162 LIALSPSSENNYLAYPSPQKLAPNPQTEVTLHSNPQTVRNGDVIIFDAKTLQPTSVIEAH 221 Query: 192 TGYLNTVTVSPDGSLCASGGKDGQ-AMLWDLNEGKHLYTLDGG---DIINALCFSP-NRY 246 L + +S DG L A+ G ++ + G LY G I +L FSP NR+ Sbjct: 222 RTSLAAIALSKDGLLLATASDKGTIIRVFSVATGIKLYQFRRGTYPTKIYSLAFSPDNRF 281 Query: 247 WLCAATGPSIKIWDLEGKIIVDELK 271 + ++ ++ I+ L + + +K Sbjct: 282 VIASSATETVHIFRLGEEEAANTIK 306 Score = 65.9 bits (159), Expect = 2e-11, Method: Composition-based stats. Identities = 27/115 (23%), Positives = 53/115 (46%), Gaps = 5/115 (4%) Query: 21 IATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALS 80 +A PQ + S +T+ + + P + H ++ + +S DG + Sbjct: 182 LAPNPQTEVTLH--SNPQTVRNGDVIIFDAKTLQPTSVIEAHRTSLAAIALSKDGLLLAT 239 Query: 81 GSWDGT-LRLWDLTTGTTTRRFVGHTKD--VLSVAFSSDNRQIVSGSRDKTIKLW 132 S GT +R++ + TG +F T + S+AFS DNR +++ S +T+ ++ Sbjct: 240 ASDKGTIIRVFSVATGIKLYQFRRGTYPTKIYSLAFSPDNRFVIASSATETVHIF 294 Score = 46.2 bits (108), Expect = 2e-05, Method: Composition-based stats. Identities = 19/106 (17%), Positives = 46/106 (43%), Gaps = 4/106 (3%) Query: 84 DGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKT-IKLWNT-LGVCKYT 141 +G + ++D T T H + ++A S D + + S T I++++ G+ Y Sbjct: 201 NGDVIIFDAKTLQPTSVIEAHRTSLAAIALSKDGLLLATASDKGTIIRVFSVATGIKLYQ 260 Query: 142 VQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTN 187 + ++ + + FSP+ N +++ + V ++ L + Sbjct: 261 FRRGTYPTKIYSLAFSPD--NRFVIASSATETVHIFRLGEEEAANT 304 Score = 44.3 bits (103), Expect = 7e-05, Method: Composition-based stats. Identities = 14/91 (15%), Positives = 35/91 (38%), Gaps = 5/91 (5%) Query: 3 EQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTI-IMWKLTRDETNYGIPQRALRG 61 + + ++ H + IA + ++ +AS TI ++ + Y + Sbjct: 210 KTLQPTSVIEAHRTSLAAIALSKD-GLLLATASDKGTIIRVFSVATGIKLYQFRRGTY-- 266 Query: 62 HSHFVSDVVISSDGQFALSGSWDGTLRLWDL 92 + + S D +F ++ S T+ ++ L Sbjct: 267 -PTKIYSLAFSPDNRFVIASSATETVHIFRL 296 >2VDU-B nrPDB Length = 450 Score = 62.4 bits (150), Expect = 2e-10, Method: Composition-based stats. Identities = 30/175 (17%), Positives = 69/175 (39%), Gaps = 10/175 (5%) Query: 72 SSDGQFALSGSWDGTLRLWDLT-TGTTTRRFVGH---TKDVLSVAFSSDNRQIVSGSRDK 127 S + + D +L ++D+ T + +K +++ + D+ ++ + Sbjct: 112 SDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTVIIADKFG 171 Query: 128 TIKLWNTLGVCKYTVQDE---SHSEWVSCVRFSPNSS-NPIIVSCGWDKLVKVWNLANCK 183 + + + + E H ++ V +S + I++ D+ +K+ + C Sbjct: 172 DVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYPQCF 231 Query: 184 LKTN-HIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIIN 237 + GH +++++ D L S G D + WD GK+L T D +I Sbjct: 232 IVDKWLFGHKHFVSSICCGKD-YLLLSAGGDDKIFAWDWKTGKNLSTFDYNSLIK 285 Score = 42.4 bits (98), Expect = 3e-04, Method: Composition-based stats. Identities = 24/93 (25%), Positives = 34/93 (36%), Gaps = 7/93 (7%) Query: 13 GHNGWVTQIATTPQFPD--MILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVV 70 GH +T + I+++ RD+ I + I + L GH HFVS + Sbjct: 193 GHVSMLTDVHLIKDSDGHQFIITSDRDEHIKI----SHYPQCFIVDKWLFGHKHFVSSIC 248 Query: 71 ISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVG 103 D LS D + WD TG F Sbjct: 249 CGKD-YLLLSAGGDDKIFAWDWKTGKNLSTFDY 280 Score = 33.1 bits (74), Expect = 0.17, Method: Composition-based stats. Identities = 21/164 (12%), Positives = 48/164 (29%), Gaps = 8/164 (4%) Query: 159 NSSNPIIVSCGWDKLVKVWNL----ANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDG 214 + + +I DK + V+++ N + N ++++ D + K G Sbjct: 112 SDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTVIIADKFG 171 Query: 215 QAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEV 274 D+N I+ + + + + + G I + I + Sbjct: 172 DVYSIDINS-IPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYPQC 230 Query: 275 ISTSS--KAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGT 316 +S+ D L + D+ + W G Sbjct: 231 FIVDKWLFGHKHFVSSICCGKD-YLLLSAGGDDKIFAWDWKTGK 273 >3DW8-B nrPDB Length = 447 Score = 61.2 bits (147), Expect = 6e-10, Method: Composition-based stats. Identities = 55/327 (16%), Positives = 105/327 (32%), Gaps = 69/327 (21%) Query: 15 NGWVTQIATTPQFP--DMILSASRDKTIIMWKLTRDET-----NYGIPQRALRGHSHFVS 67 + +I PQ +LS + DKTI +WK++ + N R + + Sbjct: 93 EEKINKIRWLPQKNAAQFLLS-TNDKTIKLWKISERDKRPEGYNLKEEDGRYRDPTTVTT 151 Query: 68 -DVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVG-HTKDVLSVAFSSDNRQIVSGSR 125 V + + S R F HT + S++ +SD +S Sbjct: 152 LRVPVFRPMDLMVEAS--------------PRRIFANAHTYHINSISINSDYETYLSA-D 196 Query: 126 DKTIKLWNTLGVCK-------YTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWN 178 D I LW+ + E +E ++ F PNS N + S +++ + Sbjct: 197 DLRINLWHLEITDRSFNIVDIKPANMEELTEVITAAEFHPNSCNTFVYSSSK-GTIRLCD 255 Query: 179 LANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNE--GKHLYTLDGGDII 236 + AS D + L++ E + + I Sbjct: 256 MR---------------------------ASALCDRHSKLFEEPEDPSNRSFFSEIISSI 288 Query: 237 NALCFSPNRYWLCAATGPSIKIWDL-------EGKIIVDELKQEVISTSSKAEPPQCTSL 289 + + FS + ++ S+K+WDL E + + L+ ++ S Sbjct: 289 SDVKFSHSGRYMMTRDYLSVKVWDLNMENRPVETYQVHEYLRSKLCSLYENDCIFDKFEC 348 Query: 290 AWSADGQTLFAGYTDNLVRVWQVTIGT 316 W+ + G +N R++ Sbjct: 349 CWNGSDSVVMTGSYNNFFRMFDRNTKR 375 Score = 55.9 bits (133), Expect = 2e-08, Method: Composition-based stats. Identities = 49/306 (16%), Positives = 102/306 (33%), Gaps = 68/306 (22%) Query: 64 HFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLS------------- 110 +S V + G+ +G G + ++ + +V S Sbjct: 29 DIISTVEFNHSGELLATGDKGGRVVIFQQEQENKIQSHSRGEYNVYSTFQSHEPEFDYLK 88 Query: 111 ----------VAFSSDNR--QIVSGSRDKTIKLWNTLGVCKYTVQDESHSE--------W 150 + + Q + + DKTIKLW K E Sbjct: 89 SLEIEEKINKIRWLPQKNAAQFLLSTNDKTIKLWKISERDKRPEGYNLKEEDGRYRDPTT 148 Query: 151 VSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASG 210 V+ +R ++V + HT ++N+++++ D S Sbjct: 149 VTTLRVPVFRPMDLMVEAS-------------PRRIFANAHTYHINSISINSDYETYLSA 195 Query: 211 GKDGQAMLWDLN---------EGKHLYTLDGGDIINALCFSPNR--YWLCAATGPSIKIW 259 D + LW L + K + ++I A F PN ++ +++ +I++ Sbjct: 196 -DDLRINLWHLEITDRSFNIVDIKPANMEELTEVITAAEFHPNSCNTFVYSSSKGTIRLC 254 Query: 260 DLEGKIIVD---ELKQEVISTSSKAEPPQCTS----LAWSADGQTLFAGYTDN-LVRVWQ 311 D+ + D +L +E S+++ + S + +S G+ + D V+VW Sbjct: 255 DMRASALCDRHSKLFEEPEDPSNRSFFSEIISSISDVKFSHSGRYMMT--RDYLSVKVWD 312 Query: 312 VTIGTR 317 + + R Sbjct: 313 LNMENR 318 Score = 48.5 bits (114), Expect = 4e-06, Method: Composition-based stats. Identities = 24/231 (10%), Positives = 67/231 (29%), Gaps = 49/231 (21%) Query: 15 NGWVTQIATTPQFPDMILSASRDKTI---------------IMWKLTRDETNYGIPQRAL 59 +T P + + +S TI +++ D +N + Sbjct: 226 TEVITAAEFHPNSCNTFVYSSSKGTIRLCDMRASALCDRHSKLFEEPEDPSNRSFFSEII 285 Query: 60 RGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLT-TGTTTRRFVGHTK------------ 106 +SDV S G++ ++ + ++++WDL + H Sbjct: 286 ----SSISDVKFSHSGRYMMTRDY-LSVKVWDLNMENRPVETYQVHEYLRSKLCSLYEND 340 Query: 107 ---DVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNP 163 D ++ + +++GS + ++++ T++ + V Sbjct: 341 CIFDKFECCWNGSDSVVMTGSYNNFFRMFDRNTKRDITLEASRENNKPRTVL----KPRK 396 Query: 164 IIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDG 214 + S ++ + + + P ++ A + Sbjct: 397 VCASG---------KRKKDEISVDSLDFNKKILHTAWHPKENIIAVATTNN 438 >5AMS-A nrPDB Length = 431 Score = 58.6 bits (140), Expect = 4e-09, Method: Composition-based stats. Identities = 29/194 (14%), Positives = 63/194 (32%), Gaps = 20/194 (10%) Query: 137 VCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKT--NHIGHTGY 194 + H++ V + PN P++ + G D L +W + K G+ Sbjct: 54 SNNSLTYFDKHTDSVFAIGHHPNL--PLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGES 111 Query: 195 LNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGG-DIINALCF---SPN--RYWL 248 + + + + +G + G+ ++ +G + L + + + P R + Sbjct: 112 VISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFA 171 Query: 249 CAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQ-----TLFAGYT 303 AT S +W + L+Q S C+ + + L Sbjct: 172 FGATDGS--VWCYQINEQDGSLEQ---LMSGFVHQQDCSMGEFINTDKGENTLELVTCSL 226 Query: 304 DNLVRVWQVTIGTR 317 D+ + W G + Sbjct: 227 DSTIVAWNCFTGQQ 240 Score = 57.0 bits (136), Expect = 1e-08, Method: Composition-based stats. Identities = 33/244 (13%), Positives = 66/244 (27%), Gaps = 28/244 (11%) Query: 94 TGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLG-VCKYTVQDESHSEWVS 152 + + F HT V ++ + + +G D LW + K+ + E V Sbjct: 54 SNNSLTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVI 113 Query: 153 CVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDG----SLCA 208 F S +V+ V V + + + A Sbjct: 114 SCSF--TSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFA 171 Query: 209 SGGKDGQAMLWDLNE-----GKHLYTLDGGDIINALCFSPNR------YWLCAATGPSIK 257 G DG + +NE + + + F + + +I Sbjct: 172 FGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIV 231 Query: 258 IWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSAD------GQTLFAGYTDNLVRVWQ 311 W+ + ++ Q I SL+ + + + G + L+ V Sbjct: 232 AWNCFTGQQLFKITQAEIKGLEAPW----ISLSLAPETLTKGNSGVVACGSNNGLLAVIN 287 Query: 312 VTIG 315 G Sbjct: 288 CNNG 291 Score = 50.8 bits (120), Expect = 7e-07, Method: Composition-based stats. Identities = 30/217 (13%), Positives = 74/217 (34%), Gaps = 30/217 (13%) Query: 31 ILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISS------DGQFALSGSWD 84 +++ S D TI+ W + + I Q ++G + ++ + GS + Sbjct: 221 LVTCSLDSTIVAWNCFTGQQLFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSNN 280 Query: 85 GTLRLWDLTTGTTTRRFVGH----------TKDVLSVAFSSDNRQIVSGSRDKTIKLWNT 134 G L + + G + S+++SS + G I L++T Sbjct: 281 GLLAVINCNNGGAILHLSTVIELKPEQDELDASIESISWSSKFSLMAIGLVCGEILLYDT 340 Query: 135 LGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGY 194 + V+ + F + + + + V +N + K +GH Sbjct: 341 SAW--RVRHKFVLEDSVTKLMFDNDD----LFASCINGKVYQFNARTGQEKFVCVGHNMG 394 Query: 195 LNT-VTVSPDGSL-------CASGGKDGQAMLWDLNE 223 + + + P + + G +G ++++++ Sbjct: 395 VLDFILLHPVANTGTEQKRKVITAGDEGVSLVFEVPN 431 Score = 49.7 bits (117), Expect = 2e-06, Method: Composition-based stats. Identities = 32/280 (11%), Positives = 82/280 (29%), Gaps = 30/280 (10%) Query: 62 HSHFVSDVVISSDGQFALSGSWDGTLRLW--DLTTGTTTRRFVGHTKDVLSVAFSSDNRQ 119 H+ V + + +G D LW G+ + V+S +F+S+ Sbjct: 64 HTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGF 123 Query: 120 IVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSN--PIIVSCGWDKLVKVW 177 +V+ + + + S + V + + D V + Sbjct: 124 LVTADMSGKVLVH-MGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCY 182 Query: 178 NLA----NCKLKTNHIGHTG------YLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHL 227 + + + + H ++NT + + D + W+ G+ L Sbjct: 183 QINEQDGSLEQLMSGFVHQQDCSMGEFINT-DKGENTLELVTCSLDSTIVAWNCFTGQQL 241 Query: 228 YTLDGGD------IINALCFSPN-------RYWLCAATGPSIKIWDLEGKIIVDELKQEV 274 + + + +L +P C + + + + + L + Sbjct: 242 FKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSNNGLLAVINCNNGGAILHLSTVI 301 Query: 275 ISTSSKAE-PPQCTSLAWSADGQTLFAGYTDNLVRVWQVT 313 + E S++WS+ + G + ++ + Sbjct: 302 ELKPEQDELDASIESISWSSKFSLMAIGLVCGEILLYDTS 341 Score = 38.5 bits (88), Expect = 0.004, Method: Composition-based stats. Identities = 13/89 (14%), Positives = 29/89 (32%), Gaps = 8/89 (8%) Query: 220 DLNEGKHLYTLDGGDIINALCFSPNRYWLCAATGPSI-KIWDLEGKIIVDELKQEVISTS 278 D++ Y D + A+ PN +C G ++ +W + + + Sbjct: 52 DMSNNSLTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLW-------TSHSQPPKFAGT 104 Query: 279 SKAEPPQCTSLAWSADGQTLFAGYTDNLV 307 S +++++G L V Sbjct: 105 LTGYGESVISCSFTSEGGFLVTADMSGKV 133 >6CVZ-A nrPDB Length = 351 Score = 58.2 bits (139), Expect = 5e-09, Method: Composition-based stats. Identities = 53/297 (17%), Positives = 96/297 (32%), Gaps = 48/297 (16%) Query: 2 TEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRG 61 T M + H + +A + ++LSAS D TI + T ETN + Sbjct: 61 TANMKSSQYIPMHGKQIRGLAFSSYLRGLLLSASLDNTIKL---TSLETNTVVQTYNA-- 115 Query: 62 HSHFVSDVVISSD-GQFALSGSWDGTLRLWDLTT------------GTTTRRFVGHTKDV 108 V D + +G +G++ ++D+ + + Sbjct: 116 -GRPVWSCCWCLDEANYIYAGLANGSILVYDVRNTSSHVQELVAQKARCPLVSLSYMPRA 174 Query: 109 LSVAFSSDNRQIVSGSRDKTIKLW----NTLGVCKYT-------VQDESHSEWVSC-VRF 156 S AF + D W + + ++ + C V + Sbjct: 175 ASAAF-PYGGVLAGTLED--ASFWEQKMDFSHWPHVLPLEPGGCIDFQTENSSRHCLVTY 231 Query: 157 SPNSSNPIIVSCGWDKLVKVWNLAN----CKLKTNHIG----HTGYLNTVTVSP--DGSL 206 P+ ++ I S + ++ + N C+ G N + SP DG++ Sbjct: 232 RPDKNHTTIRSVLMEMSYRLDDTGNPICSCQPVHTFFGGPTCKLLTKNAIFQSPENDGNI 291 Query: 207 CASGGKD--GQAMLWDLNEGKHLYTLDGGDIINALC-FSPNRY-WLCAATGPSIKIW 259 G + A+LWD G L L + +C F NR +L T + I+ Sbjct: 292 LVCTGDEAANSALLWDAASGSLLQDLQTDQPVLDICPFEVNRNSYLATLTEKMVHIY 348 Score = 57.8 bits (138), Expect = 7e-09, Method: Composition-based stats. Identities = 38/247 (15%), Positives = 77/247 (31%), Gaps = 38/247 (15%) Query: 62 HSHFVSDVVISSDGQ-FALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDN-RQ 119 H + + SS + LS S D T++L L T T + + + V S + D Sbjct: 73 HGKQIRGLAFSSYLRGLLLSASLDNTIKLTSLETNTVVQTY-NAGRPVWSCCWCLDEANY 131 Query: 120 IVSGSRDKTIKLWNTLGVCKYTVQDESH--SEWVSCVRFSPNSS------NPIIVSCGWD 171 I +G + +I +++ + + + + + + P ++ ++ D Sbjct: 132 IYAGLANGSILVYDVRNTSSHVQELVAQKARCPLVSLSYMPRAASAAFPYGGVLAGTLED 191 Query: 172 KLV-----------KVWNLANCKLKTNHIGHTGYLNTVTVSPD--GSLCASGGKDGQAML 218 V L ++ VT PD + S + L Sbjct: 192 ASFWEQKMDFSHWPHVLPLEPGGCIDFQTENSSRHCLVTYRPDKNHTTIRSVLMEMSYRL 251 Query: 219 WDLN----EGKHLYTLDGGDIINALCFS-------PNRYWLCAATG---PSIKIWDLEGK 264 D + ++T GG L + + L S +WD Sbjct: 252 DDTGNPICSCQPVHTFFGGPTCKLLTKNAIFQSPENDGNILVCTGDEAANSALLWDAASG 311 Query: 265 IIVDELK 271 ++ +L+ Sbjct: 312 SLLQDLQ 318 Score = 43.5 bits (101), Expect = 1e-04, Method: Composition-based stats. Identities = 30/144 (20%), Positives = 49/144 (34%), Gaps = 9/144 (6%) Query: 174 VKVWNLANCKLKTNHIGHTGYLNTVTVSPDGS-LCASGGKDGQAMLWDLNEGKHLYTLDG 232 VK+ + AN K H + + S L S D L L + T + Sbjct: 56 VKMLSTANMKSSQYIPMHGKQIRGLAFSSYLRGLLLSASLDNTIKLTSLETNTVVQTYNA 115 Query: 233 GDIINALCFSPNR--YWLCAATGPSIKIWDLEG-KIIVDEL--KQEVISTSSKAEPPQCT 287 G + + C+ + Y SI ++D+ V EL ++ S + P+ Sbjct: 116 GRPVWSCCWCLDEANYIYAGLANGSILVYDVRNTSSHVQELVAQKARCPLVSLSYMPRAA 175 Query: 288 SLAWSADGQTLFAGYTDNLVRVWQ 311 S A+ G L D W+ Sbjct: 176 SAAF-PYGGVLAGTLEDAS--FWE 196 Score = 43.1 bits (100), Expect = 1e-04, Method: Composition-based stats. Identities = 33/180 (18%), Positives = 63/180 (35%), Gaps = 21/180 (11%) Query: 87 LRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNR-QIVSGSRDKTIKLWNTLGVCKYTVQDE 145 +++ +++ H K + +AFSS R ++S S D TIKL + + Sbjct: 56 VKMLSTANMKSSQYIPMHGKQIRGLAFSSYLRGLLLSASLDNTIKLTSLETNTVVQTYNA 115 Query: 146 SHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLAN-CKLKTNHIGHTGYLNTVTVS--- 201 W C I + + + V+++ N + V++S Sbjct: 116 GRPVWSCCWCL---DEANYIYAGLANGSILVYDVRNTSSHVQELVAQKARCPLVSLSYMP 172 Query: 202 -------PDGSLCASGGKDGQAMLW----DLNEGKHLYTLDGGDIINALCFSPNRYWLCA 250 P G + A +D W D + H+ L+ G I+ + +R+ L Sbjct: 173 RAASAAFPYGGVLAGTLEDAS--FWEQKMDFSHWPHVLPLEPGGCIDFQTENSSRHCLVT 230 >5WLC-LS nrPDB Length = 594 Score = 58.2 bits (139), Expect = 5e-09, Method: Composition-based stats. Identities = 43/228 (18%), Positives = 86/228 (37%), Gaps = 26/228 (11%) Query: 11 LKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHF--VSD 68 L+G+NGW+ + ++ + I + + + G + L + + V + Sbjct: 377 LQGNNGWINIL--HSTSGLWLMGCKIEGVITDFCIDYQPISRGKFRTILIAVNAYGEVWE 434 Query: 69 VVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFV---GHTKDVLSVAFSS--DNRQIVSG 123 ++ +G +R W G + G T ++ S NR + G Sbjct: 435 FDLNKNG---------HVIRRWKDQGGVGITKIQVGGGTTTTCPALQISKIKQNRWLAVG 485 Query: 124 SRDKTIKLWN-----TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWN 178 S + L++ T + + +S ++FSP+ + S +++ + Sbjct: 486 SESGFVNLYDRNNAMTSSTPTPVAALDQLTTTISNLQFSPDGQILCMASRAVKDALRLVH 545 Query: 179 LANCKLKTNHIGH---TGYLNTVTVSPDGSLCASGGKDGQAMLWDLNE 223 L +C + +N G + +V SP G L A G + G+ LW LN Sbjct: 546 LPSCSVFSNWPTSGTPLGKVTSVAFSPSGGLLAVGNEQGKVRLWKLNH 593 Score = 55.5 bits (132), Expect = 3e-08, Method: Composition-based stats. Identities = 62/355 (17%), Positives = 113/355 (31%), Gaps = 66/355 (18%) Query: 16 GWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVI---- 71 + ++ P P ++L+ DKT+ ++ + +TN+ + L G + Sbjct: 249 SAIQSLSFHPSKP-LLLTGGYDKTLRIYHID-GKTNHLVTSLHLVG--SPIQTCTFYTSL 304 Query: 72 -SSDGQFALSGSWDGTLRLWDLTTGTTTR----------RFVGHTKD--------VLSVA 112 + + Q + + WDL+ T R GH V + Sbjct: 305 SNQNQQNIFTAGRRRYMHSWDLSLENLTHSQTAKIEKFSRLYGHESTQRSFENFKVAHLQ 364 Query: 113 FSSDNR---QIVSGSRDKTIKL-WNTLGVCKYTVQDESHSEWVSCVRFSPNSSNP---II 165 S N ++ + I + +T G+ + E C+ + P S I+ Sbjct: 365 NSQTNSVHGIVLLQGNNGWINILHSTSGLWLMGCKIEG-VITDFCIDYQPISRGKFRTIL 423 Query: 166 VSCGWDKLVKVWNLANCKLKTNHIGHTGYL---------------NTVTVSP--DGSLCA 208 ++ V ++L G + + +S A Sbjct: 424 IAVNAYGEVWEFDLNKNGHVIRRWKDQGGVGITKIQVGGGTTTTCPALQISKIKQNRWLA 483 Query: 209 SGGKDGQAMLWDLNEGKHLYT-------LDGGDIINALCFSPNRYWLCAATGPSIKIWDL 261 G + G L+D N T I+ L FSP+ LC A+ Sbjct: 484 VGSESGFVNLYDRNNAMTSSTPTPVAALDQLTTTISNLQFSPDGQILCMASRAV-----K 538 Query: 262 EGKIIVDELKQEVISTSSKAEPP--QCTSLAWSADGQTLFAGYTDNLVRVWQVTI 314 + +V V S + P + TS+A+S G L G VR+W++ Sbjct: 539 DALRLVHLPSCSVFSNWPTSGTPLGKVTSVAFSPSGGLLAVGNEQGKVRLWKLNH 593 Score = 50.8 bits (120), Expect = 7e-07, Method: Composition-based stats. Identities = 36/296 (12%), Positives = 84/296 (28%), Gaps = 64/296 (21%) Query: 62 HSHFVSDVVISSDGQFALSGSWDGTLRLWDLT--TGTTTRRFVGHTKDVLSVAF-----S 114 HS + + L+G +D TLR++ + T + + F + Sbjct: 248 HSA-IQSLSFHPSKPLLLTGGYDKTLRIYHIDGKTNHLVTSLHLVGSPIQTCTFYTSLSN 306 Query: 115 SDNRQIVSGSRDKTIKLWNT---------------------------------------- 134 + + I + R + + W+ Sbjct: 307 QNQQNIFTAGRRRYMHSWDLSLENLTHSQTAKIEKFSRLYGHESTQRSFENFKVAHLQNS 366 Query: 135 -LGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCG-----WDKLVKVWNLANCKLKTNH 188 V + ++ W++ + ++S ++ C D + ++ K +T Sbjct: 367 QTNSVHGIVLLQGNNGWINILH---STSGLWLMGCKIEGVITDFCIDYQPISRGKFRTIL 423 Query: 189 IGHT--GYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRY 246 I G + ++ +G + G + + G T I+ + NR+ Sbjct: 424 IAVNAYGEVWEFDLNKNGHVIRRWKDQGGVGITKIQVGGGTTTTCPALQISKIK--QNRW 481 Query: 247 WLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGY 302 + + ++D + ++L +S DGQ L Sbjct: 482 LAVGSESGFVNLYDRNNAMTSSTPTPVAALDQL---TTTISNLQFSPDGQILCMAS 534 Score = 34.3 bits (77), Expect = 0.063, Method: Composition-based stats. Identities = 18/97 (18%), Positives = 40/97 (41%), Gaps = 10/97 (10%) Query: 133 NTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVW--NLANCKLKTNHIG 190 + + + SHS + + F P S P++++ G+DK ++++ + L T+ Sbjct: 234 DIVRLKDANASHPSHSA-IQSLSFHP--SKPLLLTGGYDKTLRIYHIDGKTNHLVTSLHL 290 Query: 191 HTGYLNTVTV-----SPDGSLCASGGKDGQAMLWDLN 222 + T T + + + G+ WDL+ Sbjct: 291 VGSPIQTCTFYTSLSNQNQQNIFTAGRRRYMHSWDLS 327 Score = 33.5 bits (75), Expect = 0.12, Method: Composition-based stats. Identities = 8/48 (16%), Positives = 19/48 (39%), Gaps = 2/48 (4%) Query: 268 DELKQEVISTSSKAEPPQ--CTSLAWSADGQTLFAGYTDNLVRVWQVT 313 +L + ++ + P SL++ L G D +R++ + Sbjct: 231 KKLDIVRLKDANASHPSHSAIQSLSFHPSKPLLLTGGYDKTLRIYHID 278 >6IYY-A nrPDB Length = 317 Score = 51.6 bits (122), Expect = 4e-07, Method: Composition-based stats. Identities = 30/209 (14%), Positives = 59/209 (28%), Gaps = 45/209 (21%) Query: 147 HSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSL 206 H + F N + CG + +V+N K K G + V + + Sbjct: 6 HGNGLLYAGF--NQDHGCFA-CGMENGFRVYNTDPLKEKEKQEFLEGGVGHVEMLFRCNY 62 Query: 207 CA-SGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGK- 264 A GG + M+WD + K + ++ + A+ +R + IK++ Sbjct: 63 LALVGGGKKKVMIWDDLKKKTVIEIEFSTEVKAVKLRRDR--IVVVLDSMIKVFTFTHNP 120 Query: 265 -------------------------------------IIVDELKQEVISTSSKAEPPQCT 287 +VD E A + Sbjct: 121 HQLHVFETCYNPKGLCVLCPNSNNSLLAFPGTHTGHVQLVDLASTEKPPVDIPAHEGVLS 180 Query: 288 SLAWSADGQTLFAGYTDNL-VRVWQVTIG 315 +A + G + +R++ + G Sbjct: 181 CIALNLQGTRIATASEKGTLIRIFDTSSG 209 Score = 51.6 bits (122), Expect = 5e-07, Method: Composition-based stats. Identities = 27/163 (16%), Positives = 51/163 (31%), Gaps = 28/163 (17%) Query: 37 DKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALS-----------GSWDG 85 D I ++ T + H V + + G L G+ G Sbjct: 108 DSMIKVFTFTHNP------------HQLHVFETCYNPKGLCVLCPNSNNSLLAFPGTHTG 155 Query: 86 TLRLWDL-TTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKT-IKLWNTLGVCKYTVQ 143 ++L DL +T H + +A + +I + S T I++++T Sbjct: 156 HVQLVDLASTEKPPVDIPAHEGVLSCIALNLQGTRIATASEKGTLIRIFDTSSGHLIQEL 215 Query: 144 DESHSEW-VSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLK 185 + C+ F N +I V ++ + K K Sbjct: 216 RRGSQAANIYCINF--NQDASLICVSSDHGTVHIFAAEDPKSK 256 Score = 44.7 bits (104), Expect = 5e-05, Method: Composition-based stats. Identities = 22/134 (16%), Positives = 48/134 (35%), Gaps = 10/134 (7%) Query: 11 LKGHNGWVTQIATTPQFPDMILSASRDKT-IIMWKLTRDETNYGIPQRALRGHSHFVSDV 69 + H G ++ IA I +AS T I ++ + + I + + + + Sbjct: 172 IPAHEGVLSCIALN-LQGTRIATASEKGTLIRIFDTSSG---HLIQELRRGSQAANIYCI 227 Query: 70 VISSDGQFALSGSWDGTLRLWDLTTGTTT---RRFVGHTKDVLSVAFSSDNRQIVSGSRD 126 + D S GT+ ++ + +F + AF ++ +++ D Sbjct: 228 NFNQDASLICVSSDHGTVHIFAAEDPKSKWSFSKFQVPSGSPCICAFGTEPNAVIAICAD 287 Query: 127 KTI--KLWNTLGVC 138 + L+N G C Sbjct: 288 GSYYKFLFNPKGEC 301 >6N8P-A nrPDB Length = 979 Score = 51.2 bits (121), Expect = 5e-07, Method: Composition-based stats. Identities = 46/273 (16%), Positives = 86/273 (31%), Gaps = 50/273 (18%) Query: 56 QRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVG-H--TKDVLSVA 112 + G H S + S + G+ G ++L+ G F+G H V + Sbjct: 14 KTVEHGFPHQPSALGYSPSLRILAIGTRSGAIKLY----GAPGVEFMGLHQENNAVTQIH 69 Query: 113 FSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHS-----------EWVSCVRFSPNSS 161 Q+V+ D ++ LW+ + E S P+SS Sbjct: 70 LLPGQCQLVTLLDDNSLHLWSLKVKGGASELQEDESFTLRGPPGAAPSATQITVVLPHSS 129 Query: 162 NPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDL 221 ++ V V L + + T+S D L + ++++ Sbjct: 130 CELLYLGTESGNVFVVQLPAFRALEDR----------TISSDAVLQRLPEEARHRRVFEM 179 Query: 222 NEGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKA 281 E + D PN+ L + + IWDL+G ++ + Sbjct: 180 VEALQEHPRD-----------PNQ-ILIGYSRGLVVIWDLQGSRVLYHFLSSQQLEN--- 224 Query: 282 EPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTI 314 + W DG+ L + ++D W V+ Sbjct: 225 -------IWWQRDGRLLVSCHSDGSYCQWPVSS 250 Score = 45.8 bits (107), Expect = 2e-05, Method: Composition-based stats. Identities = 33/239 (13%), Positives = 73/239 (30%), Gaps = 39/239 (16%) Query: 19 TQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFA 78 + + +P ++ +R I ++ G+ L ++ V+ + + Sbjct: 25 SALGYSPSL-RILAIGTRSGAIKLYGAP------GVEFMGLHQENNAVTQIHLLPGQCQL 77 Query: 79 LSGSWDGTLRLWDLT--------TGTTTRRFVGHTKD------VLSVAFSSDNRQIVSGS 124 ++ D +L LW L + G + V S + G+ Sbjct: 78 VTLLDDNSLHLWSLKVKGGASELQEDESFTLRGPPGAAPSATQITVVLPHSSCELLYLGT 137 Query: 125 RDKTIKLWNTLGVC-------------KYTVQDESHS---EWVSCVRFSPNSSNPIIVSC 168 + + + ++ H E V ++ P N I++ Sbjct: 138 ESGNVFVVQLPAFRALEDRTISSDAVLQRLPEEARHRRVFEMVEALQEHPRDPNQILIGY 197 Query: 169 GWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHL 227 LV +W+L ++ + + + L + DG L S DG W ++ Sbjct: 198 SR-GLVVIWDLQGSRVLYHFLS-SQQLENIWWQRDGRLLVSCHSDGSYCQWPVSSEAQQ 254 Score = 41.2 bits (95), Expect = 6e-04, Method: Composition-based stats. Identities = 47/282 (16%), Positives = 78/282 (27%), Gaps = 49/282 (17%) Query: 64 HFVSDVVISS-DGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVS 122 V + D L G G + +WDL F+ ++ + ++ + D R +VS Sbjct: 178 EMVEALQEHPRDPNQILIGYSRGLVVIWDLQGSRVLYHFLS-SQQLENIWWQRDGRLLVS 236 Query: 123 GSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANC 182 D + W + P P C + Sbjct: 237 CHSDGSYCQWPVSSEAQQPEPLR---------SLVPYGPFP----CKAITRILWLTTRQG 283 Query: 183 KLKTNHIG-----HTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIIN 237 T G G + ++V DG A L E T D + Sbjct: 284 LPFTIFQGGMPRASYGDRHCISVIHDGQQTAFDFTSRVIGFTVLTEADPAATFDDPYALV 343 Query: 238 ALC-------------FSPNR-YWLCAATGPSIKIWDLEGKIIVDELK-QEVISTSSKAE 282 L + P + +L + +I + LK E I + + Sbjct: 344 VLAEEELVVIDLQTAGWPPVQLPYLASLHCSAIT---CSHHVSNIPLKLWERIIAAGSRQ 400 Query: 283 PPQCTSLAWSADGQT-----------LFAGYTDNLVRVWQVT 313 +++ W DG T L G+ D VR W + Sbjct: 401 NAHFSTMEWPIDGGTSLTPAPPQRDLLLTGHEDGTVRFWDAS 442 Score = 40.4 bits (93), Expect = 0.001, Method: Composition-based stats. Identities = 43/277 (15%), Positives = 79/277 (28%), Gaps = 71/277 (25%) Query: 18 VTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQF 77 V + P+ P+ IL +++W L Y S + ++ DG+ Sbjct: 180 VEALQEHPRDPNQILIGYSRGLVVIWDLQGSRVLYHFLS------SQQLENIWWQRDGRL 233 Query: 78 ALSGSWDGTLRLW----DLTTGTTTRRFVGH----TKDVLSVAF---------------- 113 +S DG+ W + R V + K + + + Sbjct: 234 LVSCHSDGSYCQWPVSSEAQQPEPLRSLVPYGPFPCKAITRILWLTTRQGLPFTIFQGGM 293 Query: 114 ---SSDNRQIVSGSRDKTIKLWNTLGVCK-YTVQDESHSEWVSCVRFS------------ 157 S +R +S D ++ +TV E+ ++ Sbjct: 294 PRASYGDRHCISVIHDGQQTAFDFTSRVIGFTVLTEADPAATFDDPYALVVLAEEELVVI 353 Query: 158 -------PNSSNPIIVS--CGWDKL--------VKVWN---LANCKLKTNHIGHTGYL-- 195 P P + S C +K+W A + + + Sbjct: 354 DLQTAGWPPVQLPYLASLHCSAITCSHHVSNIPLKLWERIIAAGSRQNAHFSTMEWPIDG 413 Query: 196 -NTVTVSPDGS-LCASGGKDGQAMLWDLNEGKHLYTL 230 ++T +P L +G +DG WD G L L Sbjct: 414 GTSLTPAPPQRDLLLTGHEDGTVRFWD-ASGVCLRLL 449 >5WLC-LH nrPDB Length = 896 Score = 50.5 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 42/262 (16%), Positives = 85/262 (32%), Gaps = 32/262 (12%) Query: 63 SHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVS 122 + +VS + I + GQ G G + + L R H VLS++FS D ++S Sbjct: 256 TRYVSSMAIDNMGQQLAVGFASGVISIVSLADLQ-IRLLKWHIDSVLSLSFSHDGSYLLS 314 Query: 123 GSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIV------SCGWDKLVKV 176 G +K + LW + + + + C P + ++ + D + Sbjct: 315 GGWEKVMSLWQLETNSQQFLP-RLNGIIIDCQVLGPQGNYYSLILQMTENNSNSDYQFLL 373 Query: 177 WNLANCKLKTNHIG----------HTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKH 226 N ++ K + G H + + + + S + + + Sbjct: 374 LNASDLTSKLSINGPLPVFNSTIKHIQQPISAMNTKNSNSITSLNHSKK------KQSRK 427 Query: 227 LYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVD--------ELKQEVISTS 278 L D + +P L +++I+D V+ + Sbjct: 428 LIKSRRQDFTTNVEINPINKNLYFPHISAVQIFDFYKNEQVNYQYLTSGVNNSMGKVRFE 487 Query: 279 SKAEPPQCTSLAWSADGQTLFA 300 + P T L ++ DGQ + Sbjct: 488 LNLQDPIITDLKFTKDGQWMIT 509 Score = 47.8 bits (112), Expect = 6e-06, Method: Composition-based stats. Identities = 46/284 (16%), Positives = 94/284 (33%), Gaps = 46/284 (16%) Query: 6 TLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHF 65 L+ T G +I P D++ S + W +ETN+ + + + H Sbjct: 497 DLKFTKDGQWMITYEIEYPPN--DLLSSKDLTHILKFWTKNDNETNWNLKTKVINPHGIS 554 Query: 66 VSDVVISS------DGQFALSGSWDGTLRLWDLTTGT---TTRRFV----GHTKDVLSVA 112 V I + Q L+ +G L+ W + ++ H + +S+A Sbjct: 555 VPITKILPSPRSVNNSQGCLTADNNGGLKFWSFDSHESNWCLKKISLPNFNHFSNSVSLA 614 Query: 113 FSSDNRQIVSGSRDKT-IKLWNTLGV-----CKYTVQDESHSEWVSCVRFSPNSSNPIIV 166 +S D I G DK I ++T TV + + + V+ N +N I+ Sbjct: 615 WSQDGSLIFHGFDDKLQILDFDTFKKFESLENTKTVSEFTLDSEIQTVKL-INDTNLIVA 673 Query: 167 SCGWDKLVKV--------WNLANCKLKTNHIGHTGYLNTVT--------------VSPDG 204 + + + ++L GH L T DG Sbjct: 674 TRTTLNAINLLRGQVINSFDLYPFVNGVYKNGHMDRLITCDERTGNIALVINQQLTDLDG 733 Query: 205 SLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWL 248 + + +++D + L + I+ + ++ + ++ Sbjct: 734 --VPTINYKSRIIIFDSDLSTKLGNFTHHEYISWIGWNYDTDFI 775 Score = 45.1 bits (105), Expect = 4e-05, Method: Composition-based stats. Identities = 54/347 (15%), Positives = 105/347 (30%), Gaps = 58/347 (16%) Query: 9 GTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSD 68 LK H V ++ + +LS +K + +W+L + + + + Sbjct: 291 RLLKWHIDSVLSLSFSHD-GSYLLSGGWEKVMSLWQLETNSQQFLPRLNGI-----IIDC 344 Query: 69 VVISSDGQFAL--------SGSWDGTLRLWDLTTGTTTRRFVG----------HTKDVLS 110 V+ G + + + D L + + T+ G H + +S Sbjct: 345 QVLGPQGNYYSLILQMTENNSNSDYQFLLLNASDLTSKLSINGPLPVFNSTIKHIQQPIS 404 Query: 111 VAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGW 170 + ++ I S + K + + + ++ + P+ S I Sbjct: 405 AMNTKNSNSITSLNHSKKKQSRKLIKSRRQDFTTNVEINPINKNLYFPHISAVQIFDFYK 464 Query: 171 DKLVKVWNLANC------KLKTNHIGHTGYLNTVTVSPDGSLCAS-----------GGKD 213 ++ V L + K++ + + + DG + KD Sbjct: 465 NEQVNYQYLTSGVNNSMGKVRFELNLQDPIITDLKFTKDGQWMITYEIEYPPNDLLSSKD 524 Query: 214 --GQAMLWDLNEGKHLYTLDG--------GDIINALCFSPNRY-----WLCAATGPSIKI 258 W N+ + + L I + SP L A +K Sbjct: 525 LTHILKFWTKNDNETNWNLKTKVINPHGISVPITKILPSPRSVNNSQGCLTADNNGGLKF 584 Query: 259 WDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDN 305 W + LK+ IS + SLAWS DG +F G+ D Sbjct: 585 WSFDSHESNWCLKK--ISLPNFNHFSNSVSLAWSQDGSLIFHGFDDK 629 Score = 45.1 bits (105), Expect = 4e-05, Method: Composition-based stats. Identities = 19/82 (23%), Positives = 31/82 (37%), Gaps = 7/82 (8%) Query: 15 NGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSD 74 +V+ +A + I + L + R L+ H V + S D Sbjct: 256 TRYVSSMAIDNM-GQQLAVGFASGVISIVSLAD------LQIRLLKWHIDSVLSLSFSHD 308 Query: 75 GQFALSGSWDGTLRLWDLTTGT 96 G + LSG W+ + LW L T + Sbjct: 309 GSYLLSGGWEKVMSLWQLETNS 330 Score = 39.7 bits (91), Expect = 0.001, Method: Composition-based stats. Identities = 10/38 (26%), Positives = 20/38 (52%) Query: 280 KAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGTR 317 K SL++S DG L +G + ++ +WQ+ ++ Sbjct: 294 KWHIDSVLSLSFSHDGSYLLSGGWEKVMSLWQLETNSQ 331 >5K1H-B nrPDB Length = 576 Score = 50.1 bits (118), Expect = 1e-06, Method: Composition-based stats. Identities = 48/280 (17%), Positives = 94/280 (33%), Gaps = 28/280 (10%) Query: 35 SRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTT 94 S D+T I W +D + R + V S G + + G + LW Sbjct: 143 SGDRTSIFWNDVKDPVSIEERARWTE------TYVRWSPKGTYLATFHQRG-IALWGGEK 195 Query: 95 GTTTRRFVGHTKDVLSVAFSSDNRQIVSGS------RD-KTIKLWNTL-GVCKYTVQDES 146 +RF + V + FS R +V+ S D + I +W+ L G K ES Sbjct: 196 FKQIQRFS--HQGVQLIDFSPCERYLVTFSPLMDTQDDPQAIIIWDILTGHKKRGFHCES 253 Query: 147 HSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSL 206 + W ++S D + ++ + L + + SP G++ Sbjct: 254 SAHW-PIFKWS--HDGKFFARMTLD-TLSIYETPSMGLLDKKSLKISGIKDFSWSPGGNI 309 Query: 207 CAS-GGKDG----QAMLWDLNEGKHLYTLDGGDII-NALCFSPNRYWLCAATGPSIK-IW 259 A +D + L L + + + +++ L + N +LC + K Sbjct: 310 IAFWVPEDKDIPARVTLMQLPSRQEIRVRNLFNVVDCKLHWQKNGDYLCVKVDRTPKGTQ 369 Query: 260 DLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLF 299 + + ++++ + + AW +G Sbjct: 370 GVVTNFEIFRMREKQVPVDVVEMKETIIAFAWEPNGSKFA 409 Score = 50.1 bits (118), Expect = 1e-06, Method: Composition-based stats. Identities = 33/211 (15%), Positives = 72/211 (34%), Gaps = 17/211 (8%) Query: 90 WDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSE 149 WD+ + G+ + L A D ++ S D+T WN + + +E Sbjct: 110 WDIPEKQPFKDL-GNLRYWLEEAECRDQYSVIFESGDRTSIFWNDVKDPVSIEERARWTE 168 Query: 150 WVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCAS 209 + VR+SP + + + + + +W K H G + + SP + Sbjct: 169 --TYVRWSPKGT--YLATF-HQRGIALWGGEKFKQIQRF-SHQG-VQLIDFSPCERYLVT 221 Query: 210 GG------KDGQ-AMLWDLNEGKHLYTLDGGDI--INALCFSPNRYWLCAATGPSIKIWD 260 D Q ++WD+ G +S + + T ++ I++ Sbjct: 222 FSPLMDTQDDPQAIIIWDILTGHKKRGFHCESSAHWPIFKWSHDGKFFARMTLDTLSIYE 281 Query: 261 LEGKIIVDELKQEVISTSSKAEPPQCTSLAW 291 ++D+ ++ + P +A+ Sbjct: 282 TPSMGLLDKKSLKISGIKDFSWSPGGNIIAF 312 Score = 45.8 bits (107), Expect = 2e-05, Method: Composition-based stats. Identities = 46/310 (14%), Positives = 96/310 (30%), Gaps = 37/310 (11%) Query: 14 HNGWVTQIATTP------QFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVS 67 H G V I +P F ++ + + II+W + G +R S Sbjct: 204 HQG-VQLIDFSPCERYLVTFSPLMDTQDDPQAIIIWDI-----LTGHKKRGFHCESSAHW 257 Query: 68 DV-VISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQI-VSGSR 125 + S DG+F + D TL +++ + + + ++S I Sbjct: 258 PIFKWSHDGKFFARMTLD-TLSIYETPSMGLLDKKSLKISGIKDFSWSPGGNIIAFWVPE 316 Query: 126 DKTIKLWNTLGVCKYTVQDESHS--EWVSC-VRFSPNSSNPII-------VSCGWDKLVK 175 DK I TL + + V C + + N + + G + Sbjct: 317 DKDIPARVTLMQLPSRQEIRVRNLFNVVDCKLHWQKNGDYLCVKVDRTPKGTQGVVTNFE 376 Query: 176 VWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDG---QAMLWDLNE--GKHLYTL 230 ++ + ++ + + + P+GS A + + + L + Sbjct: 377 IFRMREKQVPVDVVEMKETIIAFAWEPNGSKFAVLHGEAPRISVSFYHVKSNGKIELSKM 436 Query: 231 DGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLA 290 N + +SP ++ A S+ VD + + AE + + Sbjct: 437 FDKQQANTIFWSPQGQFVVLAGLRSMN----GALAFVDTSD---CTVMNIAEHYMASDVE 489 Query: 291 WSADGQTLFA 300 W G+ + Sbjct: 490 WDPTGRYVVT 499 Score = 39.3 bits (90), Expect = 0.002, Method: Composition-based stats. Identities = 18/158 (11%), Positives = 43/158 (27%), Gaps = 22/158 (13%) Query: 170 WDKLVKV---WNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKH 226 +DK + + W++ + + +L D D ++ W+ + Sbjct: 100 FDKYMTISDEWDIPEKQPFKDLGNLRYWLEEAEC-RDQYSVIFESGDRTSIFWNDVKDPV 158 Query: 227 LYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQC 286 + +SP +L I +W E + + Sbjct: 159 SIEERARWTETYVRWSPKGTYLATFHQRGIALWGGEKFKQIQRFSHQ-----------GV 207 Query: 287 TSLAWSADGQTLFAGY------TD-NLVRVWQVTIGTR 317 + +S + L D + +W + G + Sbjct: 208 QLIDFSPCERYLVTFSPLMDTQDDPQAIIIWDILTGHK 245 >4AV8-A nrPDB Length = 339 Score = 49.3 bits (116), Expect = 2e-06, Method: Composition-based stats. Identities = 22/144 (15%), Positives = 51/144 (35%), Gaps = 9/144 (6%) Query: 38 KTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGT-LRLWDLTTGT 96 I + +L D ++ H++ V V ++ G + S DGT +R++ G Sbjct: 154 GQIHVTRLQTDAEQVVGKGVLVKAHANPVKMVRLNRKGDMVATCSQDGTLIRVFQTDNGV 213 Query: 97 TTRRFVGHTKD--VLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSC- 153 R F ++ + +S D ++ S T+ ++ + +W++ Sbjct: 214 LVREFRRGLDRTSIIDMRWSPDGSKLAVVSDKWTLHVFEVFNDAENKRHVLK--DWINIK 271 Query: 154 ---VRFSPNSSNPIIVSCGWDKLV 174 +S + + D + Sbjct: 272 YFQSEWSICNFKLKVSKGSNDCKI 295 Score = 47.0 bits (110), Expect = 1e-05, Method: Composition-based stats. Identities = 26/102 (25%), Positives = 44/102 (43%), Gaps = 10/102 (9%) Query: 3 EQMTLRGTL-KGHNGWVTQIATTPQFPDMILSASRDKT-IIMWKLTRDETNYGIPQRALR 60 EQ+ +G L K H V + + DM+ + S+D T I ++ +T+ G+ R R Sbjct: 166 EQVVGKGVLVKAHANPVKMVRLNRK-GDMVATCSQDGTLIRVF-----QTDNGVLVREFR 219 Query: 61 GHSHFVS--DVVISSDGQFALSGSWDGTLRLWDLTTGTTTRR 100 S D+ S DG S TL ++++ +R Sbjct: 220 RGLDRTSIIDMRWSPDGSKLAVVSDKWTLHVFEVFNDAENKR 261 Score = 45.5 bits (106), Expect = 3e-05, Method: Composition-based stats. Identities = 27/144 (18%), Positives = 50/144 (34%), Gaps = 11/144 (7%) Query: 133 NTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKL-VKVWNLANCKLKTNHIG- 190 + V V ++H+ V VR N ++ +C D ++V+ N L Sbjct: 164 DAEQVVGKGVLVKAHANPVKMVRL--NRKGDMVATCSQDGTLIRVFQTDNGVLVREFRRG 221 Query: 191 -HTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIIN----ALCFSPNR 245 + + SPDGS A ++++ D IN +S Sbjct: 222 LDRTSIIDMRWSPDGSKLAVVSDKWTLHVFEVFNDAENKRHVLKDWINIKYFQSEWSICN 281 Query: 246 YWLCAATG-PSIKI-WDLEGKIIV 267 + L + G KI W + +++ Sbjct: 282 FKLKVSKGSNDCKIAWISDTGLVI 305 Score = 41.6 bits (96), Expect = 4e-04, Method: Composition-based stats. Identities = 37/265 (13%), Positives = 88/265 (33%), Gaps = 28/265 (10%) Query: 61 GHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQI 120 S+ + D + D + + + ++++ + + N Sbjct: 12 HVSNPIVDYEFNQDQSCLIVSTP-KSFDIYNVHPLKRIMSQEMPDAGTIRM-LHRTNYIA 69 Query: 121 VSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLA 180 ++ + + +W+ + T + + V+ S I+VS G ++ ++ Sbjct: 70 FVSTKKELLHIWDDVKKQDIT-----RVKLDAAVKDLFLSREFIVVSQGD--VISIFKFG 122 Query: 181 NCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKD-GQAMLWDLNE------GKHLYTLDGG 233 N K G + +G L S + GQ + L GK + Sbjct: 123 NPWNKITEDIKFGGVCEFA---NGLLVYSNEFNLGQIHVTRLQTDAEQVVGKGVLVKAHA 179 Query: 234 DIINALCFSPNRYWL--CAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAW 291 + + + + + C+ G I+++ + ++V E ++ + TS + W Sbjct: 180 NPVKMVRLNRKGDMVATCSQDGTLIRVFQTDNGVLVREFRRGLDRTS-------IIDMRW 232 Query: 292 SADGQTLFAGYTDNLVRVWQVTIGT 316 S DG L + V++V Sbjct: 233 SPDGSKLAVVSDKWTLHVFEVFNDA 257 >4FHN-A nrPDB Length = 394 Score = 48.5 bits (114), Expect = 3e-06, Method: Composition-based stats. Identities = 31/157 (19%), Positives = 62/157 (39%), Gaps = 13/157 (8%) Query: 14 HNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDV---- 69 H+G + ++P + + +D T+ + + GH +FV+D+ Sbjct: 89 HDGDGN-VNSSPVYSLFLACVCQDNTVRLIITKNETIITQHVLGGKSGHHNFVNDIDIAD 147 Query: 70 VISSDGQF----ALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDN-RQIVSGS 124 V S+D + S D TL +W LT + +SV F N Q++ G Sbjct: 148 VYSADNRLAEQVIASVGDDCTLIIWRLTDEGPILAGYPLSSPGISVQFRPSNPNQLIVGE 207 Query: 125 RDKTIKLWN---TLGVCKYTVQDESHSEWVSCVRFSP 158 R+ I++++ L + + + + W+ + P Sbjct: 208 RNGNIRIFDWTLNLSAEENSQTELVKNPWLLTLNTLP 244 Score = 46.2 bits (108), Expect = 2e-05, Method: Composition-based stats. Identities = 24/113 (21%), Positives = 42/113 (37%), Gaps = 16/113 (14%) Query: 164 IIVSCGWDKLVKVWNLANCKLKTNHI-----GHTGYLNTVT----VSPD----GSLCASG 210 + D V++ N + T H+ GH ++N + S D + AS Sbjct: 104 FLACVCQDNTVRLIITKNETIITQHVLGGKSGHHNFVNDIDIADVYSADNRLAEQVIASV 163 Query: 211 GKDGQAMLWDLN-EGKHLYTLDGGDIINALCFSPNRY--WLCAATGPSIKIWD 260 G D ++W L EG L ++ F P+ + +I+I+D Sbjct: 164 GDDCTLIIWRLTDEGPILAGYPLSSPGISVQFRPSNPNQLIVGERNGNIRIFD 216 Score = 39.7 bits (91), Expect = 0.002, Method: Composition-based stats. Identities = 19/115 (16%), Positives = 39/115 (33%), Gaps = 11/115 (9%) Query: 119 QIVSGSRDKTIKLWNTLGVCKYTVQD----ESHSEWVSCVRFSPNSS------NPIIVSC 168 + +D T++L T T H +V+ + + S +I S Sbjct: 104 FLACVCQDNTVRLIITKNETIITQHVLGGKSGHHNFVNDIDIADVYSADNRLAEQVIASV 163 Query: 169 GWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSP-DGSLCASGGKDGQAMLWDLN 222 G D + +W L + + +V P + + G ++G ++D Sbjct: 164 GDDCTLIIWRLTDEGPILAGYPLSSPGISVQFRPSNPNQLIVGERNGNIRIFDWT 218 Score = 36.6 bits (83), Expect = 0.013, Method: Composition-based stats. Identities = 20/88 (22%), Positives = 33/88 (37%), Gaps = 15/88 (17%) Query: 13 GHNGWVTQIATTPQFP-------DMILSASRDKTIIMWKLTRDETNY-GIPQRALRGHSH 64 GH+ +V I + +I S D T+I+W+LT + G P S Sbjct: 135 GHHNFVNDIDIADVYSADNRLAEQVIASVGDDCTLIIWRLTDEGPILAGYPL------SS 188 Query: 65 FVSDVVISSDGQ-FALSGSWDGTLRLWD 91 V + G +G +R++D Sbjct: 189 PGISVQFRPSNPNQLIVGERNGNIRIFD 216 >5CWW-B nrPDB Length = 595 Score = 47.8 bits (112), Expect = 7e-06, Method: Composition-based stats. Identities = 22/107 (20%), Positives = 35/107 (32%), Gaps = 11/107 (10%) Query: 222 NEGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVD-----ELKQEVIS 276 G + D I L SPN+ +L T ++ I L + K + + Sbjct: 103 TAGYRIIKTPVADDIRQLVMSPNQDFLAVLTSHTVHICILPDSSHLHIQDTTPFKPKFWT 162 Query: 277 TSSKAEP---PQCTSLAWSA---DGQTLFAGYTDNLVRVWQVTIGTR 317 S W +G L D +VRVW+++ R Sbjct: 163 LGPTTHVTSRSAVVSAVWHPLGVNGHALVTVTEDAIVRVWELSTADR 209 Score = 35.1 bits (79), Expect = 0.046, Method: Composition-based stats. Identities = 17/100 (17%), Positives = 29/100 (29%), Gaps = 21/100 (21%) Query: 1 MTEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTI---IMWKLTRDETNYGIPQR 57 M+ L H I P + + +D T W L Sbjct: 122 MSPNQDFLAVLTSHT---VHICILPDSSHLHI---QDTTPFKPKFWTLGPTTHVTS---- 171 Query: 58 ALRGHSHFVSDVVISS---DGQFALSGSWDGTLRLWDLTT 94 V V +G ++ + D +R+W+L+T Sbjct: 172 -----RSAVVSAVWHPLGVNGHALVTVTEDAIVRVWELST 206 Score = 32.0 bits (71), Expect = 0.34, Method: Composition-based stats. Identities = 9/63 (14%), Positives = 21/63 (33%), Gaps = 9/63 (14%) Query: 170 WDKLVKVWNLANCKLK------TNHIGHTGYLNTVTVSP---DGSLCASGGKDGQAMLWD 220 + + + K K T H+ + + P +G + +D +W+ Sbjct: 144 DSSHLHIQDTTPFKPKFWTLGPTTHVTSRSAVVSAVWHPLGVNGHALVTVTEDAIVRVWE 203 Query: 221 LNE 223 L+ Sbjct: 204 LST 206 >5WLC-LV nrPDB Length = 707 Score = 47.8 bits (112), Expect = 7e-06, Method: Composition-based stats. Identities = 34/212 (16%), Positives = 79/212 (37%), Gaps = 22/212 (10%) Query: 111 VAFSSDNRQ-IVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCG 169 + S D + + +G+ I +++ +++ + H++ + V F I+S Sbjct: 62 IKVSRDGQYCMATGTYKPQIHVYD---FANLSLKFDRHTDAEN-VDF-------TILSDD 110 Query: 170 WDKLVKVWNLANCKLKTNHIGH-----TGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEG 224 W K V + N + + + H + ++ + G + +L +G Sbjct: 111 WTKSVHLQNDRSIQFQNKGGLHYTTRIPKFGRSLVYNKVNCDLYVGASGNELYRLNLEKG 170 Query: 225 KHLYTLD-GGDIINALCFSPNRYWLCAATGPSIK-IWDLEGKIIVDELKQEVISTSSKAE 282 + L + +N + + L A T ++ WD + V +L E + Sbjct: 171 RFLNPFKLDTEGVNHVSINEVNGLLAAGTETNVVEFWDPRSRSRVSKLYLE---NNIDNR 227 Query: 283 PPQCTSLAWSADGQTLFAGYTDNLVRVWQVTI 314 P Q T+ ++ DG T G ++ ++ + Sbjct: 228 PFQVTTTSFRNDGLTFACGTSNGYSYIYDLRT 259 Score = 38.5 bits (88), Expect = 0.004, Method: Composition-based stats. Identities = 20/125 (16%), Positives = 49/125 (39%), Gaps = 9/125 (7%) Query: 15 NGWVTQIATTPQFPDMILSASRDKTIIMWKL-TRDETNYGIPQRALRGHSHFVSDVVISS 73 V ++ + ++ + + + W +R + + + V+ + Sbjct: 180 TEGVNHVSIN-EVNGLLAAGTETNVVEFWDPRSRSRVSKLYLENNIDNRPFQVTTTSFRN 238 Query: 74 DGQFALSGSWDGTLRLWDLTTGT-TTRRFVGHTKDVLSVAFSSD---NRQIVSGSRDKTI 129 DG G+ +G ++DL T + + G+ D+ + + + +IV+ DK I Sbjct: 239 DGLTFACGTSNGYSYIYDLRTSEPSIIKDQGYGFDIKKIIWLDNVGTENKIVTC--DKRI 296 Query: 130 -KLWN 133 K+W+ Sbjct: 297 AKIWD 301 >3WJ9-A nrPDB Length = 412 Score = 47.0 bits (110), Expect = 1e-05, Method: Composition-based stats. Identities = 32/134 (23%), Positives = 49/134 (36%), Gaps = 24/134 (17%) Query: 192 TGYLNTVTVSPDGSLC--ASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPN-RYWL 248 G ++ V + D G + ++D + ++ N L FSPN RY L Sbjct: 268 EGPIHDVCWNADSKEFGIVYGYMPAKTAIFDNRAN--VVSIIPPAPRNTLIFSPNSRYIL 325 Query: 249 CAATGP---SIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYT-- 303 A G SI I+D + + E CT +S D Q L T Sbjct: 326 LAGFGNLQGSIDIFDAANN----------MKKITTVEAANCTYCEFSPDSQFLLTAVTSP 375 Query: 304 ----DNLVRVWQVT 313 DN +++W +T Sbjct: 376 RLRVDNSIKIWHIT 389 Score = 39.3 bits (90), Expect = 0.003, Method: Composition-based stats. Identities = 12/84 (14%), Positives = 32/84 (38%), Gaps = 12/84 (14%) Query: 67 SDVVISSDGQFALSGS---WDGTLRLWDLTTG-TTTRRFVGHTKDVLSVAFSSDNRQIVS 122 + ++ S + ++ L G++ ++D + FS D++ +++ Sbjct: 313 NTLIFSPNSRYILLAGFGNLQGSIDIFDAANNMKKITTVEA--ANCTYCEFSPDSQFLLT 370 Query: 123 GSR------DKTIKLWNTLGVCKY 140 D +IK+W+ G + Sbjct: 371 AVTSPRLRVDNSIKIWHITGAPMF 394 Score = 34.7 bits (78), Expect = 0.059, Method: Composition-based stats. Identities = 18/91 (19%), Positives = 27/91 (29%), Gaps = 20/91 (21%) Query: 234 DIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSA 293 + C+SPN AT + I D E + +L L +S Sbjct: 35 EPARNACYSPNGKLFAYATATQVVINDTESGAKLTQLPAANTYE-----------LGFSP 83 Query: 294 DGQTLFA---------GYTDNLVRVWQVTIG 315 G+ L G ++VW G Sbjct: 84 LGKYLSTWERPGKEADGTPKQNMKVWNTETG 114 >4NOX-A nrPDB Length = 746 Score = 44.7 bits (104), Expect = 5e-05, Method: Composition-based stats. Identities = 29/155 (18%), Positives = 43/155 (27%), Gaps = 30/155 (19%) Query: 171 DKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTL 230 D + WN + + V SP G+ S G LW L Sbjct: 177 DTVGVFWNNEKDQPENIVDRQHWTETFVQWSPLGTYLTSVHAQG-VQLWGGASWSRLRRF 235 Query: 231 DGGDIINALCFSPNRYWLCAATGPSIK-------------------IWDLEGKIIVDELK 271 +N + FSP +L + I+ IWD+E + Sbjct: 236 P-HPFVNLVAFSPGEKYLVTWSNRPIQIPDSGHPVLTLDDDGKNYIIWDIETARPLRSFA 294 Query: 272 QEVISTSSKA-------EPPQCTSLAWSADGQTLF 299 Q+ I P WSAD + + Sbjct: 295 QQDIHPEEHGPKKGPPKFPWPVF--KWSADDKYVA 327 Score = 36.6 bits (83), Expect = 0.016, Method: Composition-based stats. Identities = 38/339 (11%), Positives = 100/339 (29%), Gaps = 68/339 (20%) Query: 25 PQFPDMILSASRDKT-IIMWKLTRDETNYGIPQRAL--------RGHSHFVSDV-VISSD 74 P +L+ D I+W + Q+ + +G F V S+D Sbjct: 263 PDSGHPVLTLDDDGKNYIIWDIETARPLRSFAQQDIHPEEHGPKKGPPKFPWPVFKWSAD 322 Query: 75 GQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQ--------------- 119 ++ + ++ +++L + + V+ ++ Q Sbjct: 323 DKYVARLNQGTSISIYELPKMNLLDKQAVKIEGVMDFEWAPATVQREGVKTYEQLFCFWT 382 Query: 120 -----------IVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSC 168 ++S + ++ N V + +S ++ CV+ +S + Sbjct: 383 PEIGNNPARVGLMSIPSKQIVRTLNLFSVSDVKMHWQSEGTYL-CVKVDRHSKSKK---- 437 Query: 169 GWDKLVKVWNLAN-CKLKTNHIGHTGYLNTVTVSPDGSLCA-----------SGGKDGQA 216 ++++ + + P G + Sbjct: 438 SQATTLEIFRVKEKGVPVEVVDTIKDTVINFAWEPKGDRFVIITTPEPVGATAVPPKTSV 497 Query: 217 MLW--DLNEGKHLYTLDGGDII-----NALCFSPNRYWLCAAT-----GPSIKIWDLEGK 264 + +L +G + + + NA+ +SP ++ AT ++ WDL+ Sbjct: 498 SFFCPELKKGNQVGSFKHLRTLEKKNHNAIYWSPKGRFVVIATVHNTQSSDLEFWDLDFD 557 Query: 265 IIVDELKQEVISTS---SKAEPPQCTSLAWSADGQTLFA 300 E ++++ + + T + W G+ + Sbjct: 558 GEKPENEKDLAACLQLMGTGDHYGITDVEWDPSGRYVAT 596 Score = 34.7 bits (78), Expect = 0.057, Method: Composition-based stats. Identities = 14/115 (12%), Positives = 33/115 (28%), Gaps = 12/115 (10%) Query: 212 KDGQAMLWDLNEGKHLYTLDGGDIINA-LCFSPNRYWLCAATGPSIKIWDLEGKIIVDEL 270 D + W+ + + +D + +SP +L + +++W + Sbjct: 176 GDTVGVFWNNEKDQPENIVDRQHWTETFVQWSPLGTYLTSVHAQGVQLWGGASWSRLRRF 235 Query: 271 KQEVISTSSKAEPPQCTSLAWSA-------DGQTLFAGYTD--NLVRVWQVTIGT 316 P + + WS G + D N + +W + Sbjct: 236 -PHPFVNLVAFSPGEKYLVTWSNRPIQIPDSGHPVLTLDDDGKNYI-IWDIETAR 288 Score = 34.7 bits (78), Expect = 0.061, Method: Composition-based stats. Identities = 16/124 (12%), Positives = 34/124 (27%), Gaps = 26/124 (20%) Query: 63 SHFVSDVVISSDGQFALSGSWDGT----LRLWDLTTGT-----------TTRRF-VGHTK 106 + + S G+F + + T L WDL + G Sbjct: 521 KKNHNAIYWSPKGRFVVIATVHNTQSSDLEFWDLDFDGEKPENEKDLAACLQLMGTGDHY 580 Query: 107 DVLSVAFSSDNRQIVS------GSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNS 160 + V + R + + + + L++ G E +W ++ P Sbjct: 581 GITDVEWDPSGRYVATWASAWKHTMENGYHLYDFKGELLREEHIEKFKQW----QWRPRP 636 Query: 161 SNPI 164 + Sbjct: 637 PTLL 640 Score = 30.8 bits (68), Expect = 0.76, Method: Composition-based stats. Identities = 15/93 (16%), Positives = 35/93 (37%), Gaps = 20/93 (21%) Query: 19 TQIATTPQFPDMIL-----SASRDKTIIMWKL------TRDETNYGIPQRAL-RGHSHFV 66 I +P+ +++ + S D + W L +E + + + G + + Sbjct: 525 NAIYWSPKGRFVVIATVHNTQSSD--LEFWDLDFDGEKPENEKDLAACLQLMGTGDHYGI 582 Query: 67 SDVVISSDGQFALS--GSWDGTLR----LWDLT 93 +DV G++ + +W T+ L+D Sbjct: 583 TDVEWDPSGRYVATWASAWKHTMENGYHLYDFK 615 >5BPT-A nrPDB Length = 741 Score = 43.9 bits (102), Expect = 1e-04, Method: Composition-based stats. Identities = 16/96 (16%), Positives = 38/96 (39%), Gaps = 14/96 (14%) Query: 154 VRFSPNSSNPIIVSCGWD-------KLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSL 206 + +SP +V+ + + +VW+L + + + PDG + Sbjct: 19 LAWSPKRDLIALVNKAGEVLLHRLANIQRVWSLPPNENTG------KEVTCLAWRPDGKI 72 Query: 207 CASGGKD-GQAMLWDLNEGKHLYTLDGGDIINALCF 241 A G D + +L D+ + + L++ I+ + + Sbjct: 73 LAFGLADTKKVILCDVEKPESLHSFSLETPISCMQW 108 Score = 37.8 bits (86), Expect = 0.006, Method: Composition-based stats. Identities = 23/167 (13%), Positives = 62/167 (37%), Gaps = 14/167 (8%) Query: 21 IATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALS 80 +A +P+ D+I ++ +++ +L + + +P G V+ + DG+ Sbjct: 19 LAWSPKR-DLIALVNKAGEVLLHRLANIQRVWSLPPNENTG--KEVTCLAWRPDGKILAF 75 Query: 81 GSWD-GTLRLWDLTTGTTTRRFVGHTKDVLSVAF---SSDNRQIVS---GSRDKTIKLWN 133 G D + L D+ + F + + + + +N + S + + L Sbjct: 76 GLADTKKVILCDVEKPESLHSFSL-ETPISCMQWMEVNVENSVLTSFYNAEDEANVLLPK 134 Query: 134 TLGVCKY---TVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVW 177 + K T + S + ++ ++ +V G ++++ Sbjct: 135 LPALPKNYTATAKIFSEEKSDEILKLLGDARLNALVLGGDSGQIEIY 181 Score = 31.6 bits (70), Expect = 0.42, Method: Composition-based stats. Identities = 17/71 (23%), Positives = 24/71 (33%), Gaps = 7/71 (9%) Query: 235 IINALCFSPNRYWLC-AATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSA 293 I L +SP R + + + L V L + + T LAW Sbjct: 15 EIIFLAWSPKRDLIALVNKAGEVLLHRLANIQRVWSLPPNENTGK------EVTCLAWRP 68 Query: 294 DGQTLFAGYTD 304 DG+ L G D Sbjct: 69 DGKILAFGLAD 79 Score = 30.4 bits (67), Expect = 0.93, Method: Composition-based stats. Identities = 14/65 (21%), Positives = 26/65 (40%), Gaps = 4/65 (6%) Query: 198 VTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLD----GGDIINALCFSPNRYWLCAATG 253 + SP L A K G+ +L L + +++L G + L + P+ L Sbjct: 19 LAWSPKRDLIALVNKAGEVLLHRLANIQRVWSLPPNENTGKEVTCLAWRPDGKILAFGLA 78 Query: 254 PSIKI 258 + K+ Sbjct: 79 DTKKV 83 >4MHC-A nrPDB Length = 826 Score = 42.0 bits (97), Expect = 4e-04, Method: Composition-based stats. Identities = 24/114 (21%), Positives = 41/114 (35%), Gaps = 12/114 (10%) Query: 211 GKDGQAMLWDLNEGKHLYTLDGGD----IINALCFSPN------RYWLCAATGPSIKIWD 260 D + +LW++N + +D + + + SPN L AT I I Sbjct: 108 TSDNKLILWNINNSSEYHCIDEIEHTILKVKLVKPSPNTFVSSVENLLIVATLFDIYILT 167 Query: 261 LEGKIIVDELKQEVISTSSKAEPPQCTSL-AWSADGQTLFAGYTDNLVRVWQVT 313 + EL +++ ++ GQ F G TD V VW++ Sbjct: 168 ISFNDRTHELNIFNTGLKVNVTGFNVSNIISYERTGQIFFTGATDG-VNVWELQ 220 >5BPW-A nrPDB Length = 843 Score = 40.4 bits (93), Expect = 0.001, Method: Composition-based stats. Identities = 14/96 (14%), Positives = 36/96 (37%), Gaps = 14/96 (14%) Query: 154 VRFSPNSSNPIIVSCGWDKLV-------KVWNLANCKLKTNHIGHTGYLNTVTVSPDGSL 206 + +SP + + + L+ +VW+ + + + PDG L Sbjct: 26 LVWSPKRDLIALANTAGEVLLHRLASFHRVWSFPPNENTG------KEVTCLAWRPDGKL 79 Query: 207 CASGGKD-GQAMLWDLNEGKHLYTLDGGDIINALCF 241 A D + +L D+ + + L++ ++ + + Sbjct: 80 LAFALADTKKIVLCDVEKPESLHSFSVEAPVSCMHW 115 Score = 34.7 bits (78), Expect = 0.057, Method: Composition-based stats. Identities = 10/74 (13%), Positives = 20/74 (27%), Gaps = 13/74 (17%) Query: 41 IMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWD-GTLRLWDLTTGTTTR 99 +W +E V+ + DG+ D + L D+ + Sbjct: 54 RVWSFPPNENT-----------GKEVTCLAWRPDGKLLAFALADTKKIVLCDVEKPESLH 102 Query: 100 RFVGHTKDVLSVAF 113 F V + + Sbjct: 103 SFS-VEAPVSCMHW 115 Score = 31.6 bits (70), Expect = 0.47, Method: Composition-based stats. Identities = 14/65 (21%), Positives = 24/65 (36%), Gaps = 4/65 (6%) Query: 198 VTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLD----GGDIINALCFSPNRYWLCAATG 253 + SP L A G+ +L L +++ G + L + P+ L A Sbjct: 26 LVWSPKRDLIALANTAGEVLLHRLASFHRVWSFPPNENTGKEVTCLAWRPDGKLLAFALA 85 Query: 254 PSIKI 258 + KI Sbjct: 86 DTKKI 90 Score = 31.2 bits (69), Expect = 0.62, Method: Composition-based stats. Identities = 17/72 (23%), Positives = 24/72 (33%), Gaps = 7/72 (9%) Query: 234 DIINALCFSPNRYWLC-AATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWS 292 I L +SP R + A T + + L V + + T LAW Sbjct: 21 QEIIFLVWSPKRDLIALANTAGEVLLHRLASFHRVWSFPPNENTGK------EVTCLAWR 74 Query: 293 ADGQTLFAGYTD 304 DG+ L D Sbjct: 75 PDGKLLAFALAD 86 >4YHC-A nrPDB Length = 468 Score = 40.1 bits (92), Expect = 0.001, Method: Composition-based stats. Identities = 17/114 (14%), Positives = 39/114 (34%), Gaps = 6/114 (5%) Query: 169 GWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLN---EGK 225 D + +++ + H + + VS + AS G D ++WDL Sbjct: 10 STDTTLH---EEKFRIEPVPVHHQLDILKIAVSENYKTFASVGLDRSLVVWDLRQWCTKL 66 Query: 226 HLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSS 279 L + A+ P ++ + ++ I ++E ++ + S Sbjct: 67 VLSKEQMPRTLKAIALDPQGNYVSLFSKDTLFILNVESPSLMLQHSYHSKPNSK 120 Score = 40.1 bits (92), Expect = 0.001, Method: Composition-based stats. Identities = 17/92 (18%), Positives = 36/92 (39%), Gaps = 4/92 (4%) Query: 104 HTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVC-KYTVQDESHSEWVSCVRFSPNSSN 162 H D+L +A S + + S D+++ +W+ C K + E + + P + Sbjct: 29 HQLDILKIAVSENYKTFASVGLDRSLVVWDLRQWCTKLVLSKEQMPRTLKAIALDPQGNY 88 Query: 163 PIIVSCGWDKLVKVWNLANCKLKTNHIGHTGY 194 + S + + N+ + L H H+ Sbjct: 89 VSLFSK---DTLFILNVESPSLMLQHSYHSKP 117 Score = 39.3 bits (90), Expect = 0.002, Method: Composition-based stats. Identities = 19/142 (13%), Positives = 48/142 (33%), Gaps = 15/142 (10%) Query: 134 TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTG 193 TL K+ ++ + ++ + + + S G D+ + VW+L K Sbjct: 14 TLHEEKFRIEPVPVHHQLDILKIAVSENYKTFASVGLDRSLVVWDLRQWCTKLVLSKEQM 73 Query: 194 Y--LNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINA---LCFSPNRY-- 246 L + + P G+ + KD + ++ + N+ + + P + Sbjct: 74 PRTLKAIALDPQGNYVSLFSKD-TLFILNVESPSLMLQHSYHSKPNSKLNVFWMPGTHKD 132 Query: 247 -------WLCAATGPSIKIWDL 261 + + I+++ L Sbjct: 133 DEWKNFELVVVESSGEIQVFSL 154 Score = 34.3 bits (77), Expect = 0.068, Method: Composition-based stats. Identities = 15/94 (15%), Positives = 39/94 (41%), Gaps = 5/94 (5%) Query: 14 HNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISS 73 H + +IA + + S D+++++W L + T + + + + + + Sbjct: 29 HQLDILKIAVS-ENYKTFASVGLDRSLVVWDLRQWCTKLVLSKEQM---PRTLKAIALDP 84 Query: 74 DGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKD 107 G + S D TL + ++ + + + H+K Sbjct: 85 QGNYVSLFSKD-TLFILNVESPSLMLQHSYHSKP 117 Score = 30.8 bits (68), Expect = 0.90, Method: Composition-based stats. Identities = 12/68 (17%), Positives = 25/68 (36%), Gaps = 2/68 (2%) Query: 61 GHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGH--TKDVLSVAFSSDNR 118 H + + +S + + S D +L +WDL T + + ++A Sbjct: 28 HHQLDILKIAVSENYKTFASVGLDRSLVVWDLRQWCTKLVLSKEQMPRTLKAIALDPQGN 87 Query: 119 QIVSGSRD 126 + S+D Sbjct: 88 YVSLFSKD 95 >4IMM-A nrPDB Length = 399 Score = 40.1 bits (92), Expect = 0.001, Method: Composition-based stats. Identities = 41/289 (14%), Positives = 86/289 (29%), Gaps = 48/289 (16%) Query: 49 ETNYGIPQRALRGHSHFVSDVVISSDGQFALSGS------WDGTL---------RLWDLT 93 + I A G + +V ++ SS +SG GT+ +W Sbjct: 129 RSGKLIALDARTGAARWVVELASSSLAPALISGDKVIVITNSGTIFGLDINSGATVWQYA 188 Query: 94 TGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKY------TVQDESH 147 T G K + D R ++ G D I +T+ Sbjct: 189 TQVPNTSVRGMAKP-----LALDARTVLIGGADGRIHALDTMTGAPVWTRRVGLAMGSGE 243 Query: 148 SEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLC 207 + + + +P + + + + + +++ + + +T D Sbjct: 244 IDQLRDIDGTPTVVDHYLYAASYSGQLAGFDMTTGRTM--FVSELSSTKKLTTLADA--V 299 Query: 208 ASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSP---NRYWLCAATGPSIKIWDLEGK 264 DG + ++ G+ L + D+ +P Y + I + +G+ Sbjct: 300 IGSSTDGDVVAFNRMTGEKL--WENHDLKYRGLTNPVTIGTYIAVGDADGVVHILNHQGQ 357 Query: 265 IIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVT 313 II + ++ + L+A D +V VWQ Sbjct: 358 IISRANTKGALT-------------NLTVINNRLYAQSADGVVTVWQFK 393 Score = 31.2 bits (69), Expect = 0.56, Method: Composition-based stats. Identities = 16/105 (15%), Positives = 37/105 (35%), Gaps = 10/105 (9%) Query: 29 DMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLR 88 D ++ +S D ++ + E + RG ++ V+ G + G DG + Sbjct: 297 DAVIGSSTDGDVVAFNRMTGEKLWENHDLKYRGLTNPVTI------GTYIAVGDADGVVH 350 Query: 89 LWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWN 133 + L + ++ N ++ + S D + +W Sbjct: 351 I--LNHQGQIISRANTKGALTNLTVI--NNRLYAQSADGVVTVWQ 391 >5GRS-A nrPDB Length = 396 Score = 39.7 bits (91), Expect = 0.002, Method: Composition-based stats. Identities = 17/92 (18%), Positives = 34/92 (36%), Gaps = 4/92 (4%) Query: 104 HTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVC-KYTVQDESHSEWVSCVRFSPNSSN 162 H D+L +A S + + S D+ + +W+ C K + E + + P + Sbjct: 29 HQLDILKIAVSENYKTFASVGLDRCLVVWDLRQWCTKLVLSKEQMPRTLKAIALDPQGNY 88 Query: 163 PIIVSCGWDKLVKVWNLANCKLKTNHIGHTGY 194 + S + + N+ + L H H Sbjct: 89 VSLFSK---DTLFILNVESPSLMLQHSYHCKP 117 Score = 39.3 bits (90), Expect = 0.002, Method: Composition-based stats. Identities = 16/108 (14%), Positives = 38/108 (35%), Gaps = 6/108 (5%) Query: 169 GWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLN---EGK 225 D + +++ + H + + VS + AS G D ++WDL Sbjct: 10 STDTTLH---EEKFRIEPVPVHHQLDILKIAVSENYKTFASVGLDRCLVVWDLRQWCTKL 66 Query: 226 HLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQE 273 L + A+ P ++ + ++ I ++E ++ + Sbjct: 67 VLSKEQMPRTLKAIALDPQGNYVSLFSKDTLFILNVESPSLMLQHSYH 114 Score = 38.1 bits (87), Expect = 0.005, Method: Composition-based stats. Identities = 19/142 (13%), Positives = 48/142 (33%), Gaps = 15/142 (10%) Query: 134 TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTG 193 TL K+ ++ + ++ + + + S G D+ + VW+L K Sbjct: 14 TLHEEKFRIEPVPVHHQLDILKIAVSENYKTFASVGLDRCLVVWDLRQWCTKLVLSKEQM 73 Query: 194 Y--LNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINA---LCFSPNRY-- 246 L + + P G+ + KD + ++ + N+ + + P + Sbjct: 74 PRTLKAIALDPQGNYVSLFSKD-TLFILNVESPSLMLQHSYHCKPNSKLNVFWMPGTHKD 132 Query: 247 -------WLCAATGPSIKIWDL 261 + + I+++ L Sbjct: 133 DEWKNFELVVVESSGEIQVFSL 154 Score = 30.8 bits (68), Expect = 0.86, Method: Composition-based stats. Identities = 12/68 (17%), Positives = 24/68 (35%), Gaps = 2/68 (2%) Query: 61 GHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGH--TKDVLSVAFSSDNR 118 H + + +S + + S D L +WDL T + + ++A Sbjct: 28 HHQLDILKIAVSENYKTFASVGLDRCLVVWDLRQWCTKLVLSKEQMPRTLKAIALDPQGN 87 Query: 119 QIVSGSRD 126 + S+D Sbjct: 88 YVSLFSKD 95 >5TXC-A nrPDB Length = 705 Score = 38.5 bits (88), Expect = 0.004, Method: Composition-based stats. Identities = 20/90 (22%), Positives = 29/90 (32%), Gaps = 10/90 (11%) Query: 71 ISSDGQFALSGSWD-GTLRLWDLT-TGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKT 128 S G D G +R+W + G + D+ V + DN I SG Sbjct: 134 WSPSGTHLAYLRQDQGRVRVWRASVKGEGASPVIEDAYDIEDVQWLDDNTLIYSG----- 188 Query: 129 IKLWNTLGVCKYTVQDESHSEWVSCVRFSP 158 + ++ E WV RF P Sbjct: 189 ---RPGFVEAEAEIEREGRRGWVYDERFHP 215 >2EEP-A nrPDB Length = 706 Score = 37.8 bits (86), Expect = 0.006, Method: Composition-based stats. Identities = 33/185 (17%), Positives = 65/185 (35%), Gaps = 25/185 (13%) Query: 132 WNTLGVCKYTVQDESHS-EWVSCVRFSPNSSN------PIIVSCGWDKLVKVWNLANCKL 184 W+ G C + + + V + P + P+ + V +++LA K Sbjct: 188 WSPKGSCLAFYRMDQSMVKPTPIVDYHPLEAESKPLYYPMAGTPSHHVTVGIYHLATGKT 247 Query: 185 KTNHIGH--TGYLNTVTVSPDGSLCASGGKDG-----QAMLWDLNEGKHLYTL------D 231 G +L ++ SPD ++ + + +D G+ + TL Sbjct: 248 VYLQTGEPKEKFLTNLSWSPDENILYVAEVNRAQNECKVNAYDAETGRFVRTLFVETDKH 307 Query: 232 GGDIINALCFSPNRY----WLCAATG-PSIKIWDLEGKIIVDELKQEVISTSSKAEPPQC 286 + ++ L F P W G + ++D G++I K E T+ P+ Sbjct: 308 YVEPLHPLTFLPGSNNQFIWQSRRDGWNHLYLYDTTGRLIRQVTKGEWEVTNFAGFDPKG 367 Query: 287 TSLAW 291 T L + Sbjct: 368 TRLYF 372 >5LJ5-t nrPDB Length = 503 Score = 37.4 bits (85), Expect = 0.009, Method: Composition-based stats. Identities = 20/122 (16%), Positives = 44/122 (36%), Gaps = 8/122 (6%) Query: 200 VSPDGSLCASGGKDGQAMLWDLNEGKHLYT---LDGGDIINALCFSPNRYWLCAATGPSI 256 + D L A DG +++L+ + +D I + F+ N YW+ ++ Sbjct: 338 LHKDSLLLALYSPDGILDVYNLSSPDQASSRFPVDEEAKIKEVKFADNGYWMVVECDQTV 397 Query: 257 KIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTD-NLVRVWQVTIG 315 +DL + T + + T G+ + A + N + +++ Sbjct: 398 VCFDLRKDVGTLAY---PTYTIPEFKTGTVTY-DIDDSGKNMIAYSNESNSLTIYKFDKK 453 Query: 316 TR 317 T+ Sbjct: 454 TK 455 Score = 32.7 bits (73), Expect = 0.21, Method: Composition-based stats. Identities = 24/162 (14%), Positives = 53/162 (32%), Gaps = 12/162 (7%) Query: 70 VISSDGQFALSGSWDGTLRLWDLTT--GTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDK 127 V+ D S DG L +++L++ ++R V + V F+ + +V D+ Sbjct: 337 VLHKDSLLLALYSPDGILDVYNLSSPDQASSRFPVDEEAKIKEVKFADNGYWMVVE-CDQ 395 Query: 128 TIKLWN------TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLAN 181 T+ ++ TL YT+ + + +S +I + ++ Sbjct: 396 TVVCFDLRKDVGTLAYPTYTIPEFKTGTVTYDID---DSGKNMIAYSNESNSLTIYKFDK 452 Query: 182 CKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNE 223 + + + G G A + N+ Sbjct: 453 KTKNWTKDEESALCLQSDTADFTDMDVVCGDGGIAAILKTND 494 >5WLC-LL nrPDB Length = 643 Score = 36.6 bits (83), Expect = 0.013, Method: Composition-based stats. Identities = 18/104 (17%), Positives = 38/104 (36%), Gaps = 14/104 (13%) Query: 42 MWKLTRDET--NYGIPQRALRGHSHFVSDVVIS-----SDGQ---FALSGSWDGTLRLWD 91 +W + + + + Q L H + V ++ G L S ++ L D Sbjct: 117 LWCIDSSDAFYQFDLLQFKLLQHFRINNCVQLNKLTIVPAGDSVAQLLVAS--HSISLID 174 Query: 92 LTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSR-DKTIKLWNT 134 + F GH V ++ N +SG+ D+ + +++ Sbjct: 175 IEEKKVVMTFPGHVSPVSTLQVI-TNEFFISGAEGDRFLNVYDI 217 Score = 33.1 bits (74), Expect = 0.15, Method: Composition-based stats. Identities = 17/90 (18%), Positives = 40/90 (44%), Gaps = 3/90 (3%) Query: 44 KLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSW-DGTLRLWDLTTGTTTRRFV 102 ++ + GH VS + + ++ +F +SG+ D L ++D+ +G T V Sbjct: 169 SISLIDIEEKKVVMTFPGHVSPVSTLQVITN-EFFISGAEGDRFLNVYDIHSGMTKCVLV 227 Query: 103 GHTKDVLSVAFSSDNRQIVSGSRDKTIKLW 132 D+ ++ S I + D +++++ Sbjct: 228 A-ESDIKELSHSGQADSIAVTTEDGSLEIF 256 >4ZB4-A nrPDB Length = 360 Score = 36.6 bits (83), Expect = 0.015, Method: Composition-based stats. Identities = 20/122 (16%), Positives = 44/122 (36%), Gaps = 8/122 (6%) Query: 200 VSPDGSLCASGGKDGQAMLWDLNEGKHLYT---LDGGDIINALCFSPNRYWLCAATGPSI 256 + D L A DG +++L+ + +D I + F+ N YW+ ++ Sbjct: 195 LHKDSLLLALYSPDGILDVYNLSSPDQASSRFPVDEEAKIKEVKFADNGYWMVVECDQTV 254 Query: 257 KIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTD-NLVRVWQVTIG 315 +DL + T + + T G+ + A + N + +++ Sbjct: 255 VCFDLRKDVGTLAY---PTYTIPEFKTGTVTY-DIDDSGKNMIAYSNESNSLTIYKFDKK 310 Query: 316 TR 317 T+ Sbjct: 311 TK 312 Score = 32.0 bits (71), Expect = 0.35, Method: Composition-based stats. Identities = 24/162 (14%), Positives = 53/162 (32%), Gaps = 12/162 (7%) Query: 70 VISSDGQFALSGSWDGTLRLWDLTT--GTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDK 127 V+ D S DG L +++L++ ++R V + V F+ + +V D+ Sbjct: 194 VLHKDSLLLALYSPDGILDVYNLSSPDQASSRFPVDEEAKIKEVKFADNGYWMVVE-CDQ 252 Query: 128 TIKLWN------TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLAN 181 T+ ++ TL YT+ + + +S +I + ++ Sbjct: 253 TVVCFDLRKDVGTLAYPTYTIPEFKTGTVTYDID---DSGKNMIAYSNESNSLTIYKFDK 309 Query: 182 CKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNE 223 + + + G G A + N+ Sbjct: 310 KTKNWTKDEESALCLQSDTADFTDMDVVCGDGGIAAILKTND 351 >1FLG-A nrPDB Length = 582 Score = 35.4 bits (80), Expect = 0.030, Method: Composition-based stats. Identities = 18/106 (16%), Positives = 40/106 (37%), Gaps = 6/106 (5%) Query: 172 KLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLD 231 ++ + + K+ H H L ++ G+L +G DG +D GK L+ Sbjct: 466 GSLRAMDPVSGKVVWEHKEHL-PLWAGVLATAGNLVFTGTGDGYFKAFDAKSGKELWKFQ 524 Query: 232 GGDIINA--LCFSPNRYW---LCAATGPSIKIWDLEGKIIVDELKQ 272 G I + + + + + G ++ +W + + + Q Sbjct: 525 TGSGIVSPPITWEQDGEQYLGVTVGYGGAVPLWGGDMADLTRPVAQ 570 >3TKN-A nrPDB Length = 452 Score = 34.7 bits (78), Expect = 0.061, Method: Composition-based stats. Identities = 17/71 (23%), Positives = 26/71 (36%), Gaps = 5/71 (7%) Query: 234 DIINALCFSPNRY----WLCAATGPSIKIWD-LEGKIIVDELKQEVISTSSKAEPPQCTS 288 I + F P Y + +I ++D L + L + S A T Sbjct: 125 SSIKKVLFHPKSYRDSCIVVLKEDDTITMFDILNSQEKPIVLNKPNNSFGLDARVNDITD 184 Query: 289 LAWSADGQTLF 299 L +S DG TL+ Sbjct: 185 LEFSKDGLTLY 195 >6BN7-A nrPDB Length = 864 Score = 33.5 bits (75), Expect = 0.12, Method: Composition-based stats. Identities = 19/142 (13%), Positives = 50/142 (35%), Gaps = 11/142 (7%) Query: 74 DGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKL-- 131 +G+ S + T+RL++ TT R H +++++ + I+ G +++ L Sbjct: 601 NGKLLA--SINSTVRLYEWTTEKELRTECNHYNNIMALYLKTKGDFILVGDLMRSVLLLA 658 Query: 132 WNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIG- 190 + + + + + W+S V + + G + ++ T Sbjct: 659 YKPMEGNFEEIARDFNPNWMSAVEILDDDNFL-----GAENAFNLFVCQKDSAATTDEER 713 Query: 191 -HTGYLNTVTVSPDGSLCASGG 211 H + + ++ G Sbjct: 714 QHLQEVGLFHLGEFVNVFCHGS 735 >6IGB-A nrPDB Length = 364 Score = 33.5 bits (75), Expect = 0.13, Method: Composition-based stats. Identities = 41/262 (15%), Positives = 84/262 (32%), Gaps = 46/262 (17%) Query: 81 GSWDGTLRLW--DLTTGTTTRRFV-GHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGV 137 GS +G ++++ D G+ HT + + F+ D R + + + +T+G Sbjct: 14 GSSEG-IQVYRFDGADGSVKGPLRVAHTSNPSYLTFAPDQRTLFVVNENGRGGKGDTVGR 72 Query: 138 CKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKL---VKVWNLA-------------- 180 D + + +P S D V +++ Sbjct: 73 ATSYRFDPISGRLQQISQVQTLADHPTYSSLSHDGRYLFVANYSVQPEGSVAVLPVRADG 132 Query: 181 NCKLKTNHIGHT----------GYLNTVTVSPDGSLCAS--GGKDGQAMLWDLNEGKHLY 228 + H G++++V SPDG + G D + ++ + Sbjct: 133 SLAPVVQVESHQASKVHPRQVSGHVHSVVSSPDGQYLFAPDLGAD-KVFVYRYAPEQAER 191 Query: 229 TLDGGDI----------INALCFSPNRYW--LCAATGPSIKIWDLEGKIIVDELKQEVIS 276 L D L FS + + L + ++ EG + +L+ ++ Sbjct: 192 PLQAADPAFVPTPPGSGPRHLIFSADGRFAYLTLELSGQVMVFAHEGNGRLRQLQTHDLA 251 Query: 277 TSSKAEPPQCTSLAWSADGQTL 298 + +L SADG+ L Sbjct: 252 PAGFQGKVGAGALHLSADGRFL 273 Score = 33.1 bits (74), Expect = 0.16, Method: Composition-based stats. Identities = 25/158 (15%), Positives = 52/158 (32%), Gaps = 25/158 (15%) Query: 168 CGWDKL-VKVWNLANCKLKTNH-IGHTGYLNTVTVSPDGSLCASGGKDG----------- 214 + + V ++ A+ +K + HT + +T +PD ++G Sbjct: 14 GSSEGIQVYRFDGADGSVKGPLRVAHTSNPSYLTFAPDQRTLFVVNENGRGGKGDTVGRA 73 Query: 215 QAMLWDLNEGK-----HLYTLDGGDIINALCFSPNRYWLCAAT---GPSIKIW----DLE 262 + +D G+ + TL ++L ++ + S+ + D Sbjct: 74 TSYRFDPISGRLQQISQVQTLADHPTYSSLSHDGRYLFVANYSVQPEGSVAVLPVRADGS 133 Query: 263 GKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFA 300 +V + + S+ S DGQ LFA Sbjct: 134 LAPVVQVESHQASKVHPRQVSGHVHSVVSSPDGQYLFA 171 >3AZQ-A nrPDB Length = 662 Score = 32.7 bits (73), Expect = 0.18, Method: Composition-based stats. Identities = 20/125 (16%), Positives = 36/125 (28%), Gaps = 8/125 (6%) Query: 178 NLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDL-----NEGKHLYTLDG 232 + +T G + +PDGSL + + G W+L G Sbjct: 227 DGRFADTRTLLGGPEEAIAQAEWAPDGSLIVATDRTG---WWNLHRVDPATGAATQLCRR 283 Query: 233 GDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWS 292 + ++P W I + +G ++ L E A P + + Sbjct: 284 EEEFAGPLWTPGMRWFAPLANGLIAVVHGKGAAVLGILDPESGELVDAAGPWTEWAATLT 343 Query: 293 ADGQT 297 G Sbjct: 344 VSGTR 348 >2QT9-A nrPDB Length = 766 Score = 32.7 bits (73), Expect = 0.20, Method: Composition-based stats. Identities = 18/101 (17%), Positives = 37/101 (36%), Gaps = 22/101 (21%) Query: 36 RDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFAL-------------SGS 82 ++ I+++ ++ + H ++D IS DGQF L + S Sbjct: 72 QENNILVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNYVKQWRHSYTAS 131 Query: 83 WDGTLRLWDLTTGTTTR--RFVGHTKDVLSVAFSSDNRQIV 121 +D ++DL R +T+ V +S ++ Sbjct: 132 YD----IYDLNKRQLITEERIPNNTQWVT---WSPVGHKLA 165 Score = 31.6 bits (70), Expect = 0.44, Method: Composition-based stats. Identities = 25/153 (16%), Positives = 49/153 (32%), Gaps = 23/153 (15%) Query: 170 WDKLVKVWNLANCKL-----KTNHIGHTGYLNTVTVSPDGSLC---------ASGGKDGQ 215 + + V+N + +N ++SPDG Sbjct: 72 QENNILVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNYVKQWRHSYTAS 131 Query: 216 AMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATGPSI--KIW-DLEGKIIVDELKQ 272 ++DLN+ + + + + +SP + L I KI +L I K+ Sbjct: 132 YDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKIEPNLPSYRITWTGKE 191 Query: 273 EVISTSSKAEPPQC------TSLAWSADGQTLF 299 ++I + ++L WS +G L Sbjct: 192 DIIYNGITDWVYEEEVFSAYSALWWSPNGTFLA 224 >5SUM-A nrPDB Length = 468 Score = 31.6 bits (70), Expect = 0.42, Method: Composition-based stats. Identities = 14/50 (28%), Positives = 20/50 (40%), Gaps = 1/50 (2%) Query: 192 TGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCF 241 TG + V DG GG D ++D+ K L + G IN + Sbjct: 366 TGSSTYIHVH-DGKYLLQGGLDRYVRIFDIKTNKMLVKVYVGSRINFIVM 414 Score = 31.2 bits (69), Expect = 0.55, Method: Composition-based stats. Identities = 7/23 (30%), Positives = 11/23 (47%) Query: 294 DGQTLFAGYTDNLVRVWQVTIGT 316 DG+ L G D VR++ + Sbjct: 376 DGKYLLQGGLDRYVRIFDIKTNK 398 Score = 31.2 bits (69), Expect = 0.58, Method: Composition-based stats. Identities = 8/30 (26%), Positives = 15/30 (50%) Query: 73 SDGQFALSGSWDGTLRLWDLTTGTTTRRFV 102 DG++ L G D +R++D+ T + Sbjct: 375 HDGKYLLQGGLDRYVRIFDIKTNKMLVKVY 404 >5WLC-LK nrPDB Length = 575 Score = 30.8 bits (68), Expect = 0.89, Method: Composition-based stats. Identities = 27/163 (16%), Positives = 52/163 (31%), Gaps = 21/163 (12%) Query: 162 NPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDL 221 V+ D + V++ +N K N I + + + D S D Sbjct: 99 ENFFVNGFPDGRIVVYS-SNGKDIVNIIKNKKEI--LGADTDESDIWILDSDKVVKKLQY 155 Query: 222 NEGKHLYTL-----DGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVIS 276 N K L T +I++ N L + K +V + Sbjct: 156 NNSKPLKTFTLVDGKDDEIVHFQILHQNGTLLVC----------IITKQMVYIVDPSKRR 205 Query: 277 TSSK--AEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGTR 317 S+K E + +S+DG+ L + L+ + + ++ Sbjct: 206 PSTKYSFEISDAVACEFSSDGKYLLIANNEELI-AYDLKEDSK 247 >5JRK-A nrPDB Length = 756 Score = 30.4 bits (67), Expect = 0.99, Method: Composition-based stats. Identities = 27/157 (17%), Positives = 51/157 (32%), Gaps = 35/157 (22%) Query: 150 WVSCVRFSPNSSNPIIVSCGWD-------KLVKVWNLANCKLKTNHIGHTGYLNTVTVSP 202 V+ + S N I + D +++ ++ + K T + ++ P Sbjct: 64 EVNEIALSDNGRLAIYAAEIADLDAGKPRSHIRIVDVETGRTKELLTVDT--IKSLRSVP 121 Query: 203 DGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLE 262 G +D A++ DL EG+ LY +D + L +PN + A Sbjct: 122 -------GTQDWSALV-DLGEGQQLYRIDTEGKLLPLIVNPNPVPVGKADMS-------- 165 Query: 263 GKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLF 299 + + WS DG+ L+ Sbjct: 166 ----------FPLGGGIRPSHIGILDYDWSPDGKWLW 192 >4IQB-A nrPDB Length = 315 Score = 30.4 bits (67), Expect = 1.0, Method: Composition-based stats. Identities = 13/70 (18%), Positives = 25/70 (35%), Gaps = 13/70 (18%) Query: 254 PSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDN------LV 307 +I I+ ++ K + +++T L W +G TD V Sbjct: 55 GTISIFGMQSKYCLRNGTIPLLTTKRVYWKGVLEELLW------FISGSTDGKLLMEKNV 108 Query: 308 RVWQVTIGTR 317 ++W+ G R Sbjct: 109 KIWE-KNGDR 117 >4Q1V-A nrPDB Length = 710 Score = 30.0 bits (66), Expect = 1.4, Method: Composition-based stats. Identities = 15/132 (11%), Positives = 38/132 (28%), Gaps = 15/132 (11%) Query: 71 ISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIK 130 S G D ++ T +V +V + S + Sbjct: 171 WSPKGNLLAFYRMDESMV-----TQYPLVDITARVGEVNNVRYPMAGM----TSHQVKVG 221 Query: 131 LWN-TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKL---VKVWNLANCKLKT 186 ++N G Y + + + + ++P+ + ++ D+ + +N + Sbjct: 222 IYNPATGKSIYLNAGDPTDRYFTNISWAPDEKSLYLIEVNRDQNHAKLCQYNAETGEPMG 281 Query: 187 NHIG--HTGYLN 196 H Y+ Sbjct: 282 VLYEEMHPKYVE 293 >4R40-A nrPDB Length = 411 Score = 30.0 bits (66), Expect = 1.4, Method: Composition-based stats. Identities = 39/217 (17%), Positives = 66/217 (30%), Gaps = 21/217 (9%) Query: 53 GIPQRALRGHSHFVSDVVISSDGQFALSG---SWDGTLRLWDLTTG--TTTRRFVGHTKD 107 G Q + + S DG S L + L G F H Sbjct: 170 GYNQFVVHRSPEPLMSPAWSPDGSKIAYVTFESGKSALVIQTLANGAIRQVASFPRHNGA 229 Query: 108 VLSVAFSSDNRQIVSG-SRDKTIKLW--NTLGVCKYTVQDESHSEWVSCVRFSPNSSNPI 164 AFS D ++ S+ ++ L+ + V D + + + P+S N + Sbjct: 230 P---AFSPDGTKLAFALSKSGSLNLYVMDLASGQISQVTDGRSNN--TEPSWFPDSQN-L 283 Query: 165 IVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNT-VTVSPDGSLCASGGKDG---QAMLWD 220 + +V+ + I G N VSPDG +G D Sbjct: 284 AYTSDQGGRPQVYKVNINGGVPQRITWEGSQNQNADVSPDGKFLVLVSSNGGAQHIAKQD 343 Query: 221 LNEGK-HLYTLDGGDIINALCFSPNRYWLCAATGPSI 256 L G + T D ++ PN + ++ + Sbjct: 344 LETGAVQVLTDTLLDETPSIA--PNGTMVIYSSTQGL 378 >3R3L-A nrPDB Length = 582 Score = 30.0 bits (66), Expect = 1.5, Method: Composition-based stats. Identities = 9/23 (39%), Positives = 14/23 (60%) Query: 168 CGWDKLVKVWNLANCKLKTNHIG 190 G D +V+VW++ N +L N G Sbjct: 155 AGRDGVVRVWDVKNAELLNNQFG 177 >3MWP-A nrPDB Length = 577 Score = 30.0 bits (66), Expect = 1.5, Method: Composition-based stats. Identities = 9/23 (39%), Positives = 14/23 (60%) Query: 168 CGWDKLVKVWNLANCKLKTNHIG 190 G D +V+VW++ N +L N G Sbjct: 163 AGRDGVVRVWDVKNAELLNNQFG 185 >1MG2-A nrPDB Length = 390 Score = 29.7 bits (65), Expect = 1.6, Method: Composition-based stats. Identities = 16/76 (21%), Positives = 26/76 (34%), Gaps = 11/76 (14%) Query: 172 KLVKVWNLANCKLKTNHI-GHTGYLNTVTVSPDGS--LCASGGKDGQAMLWDLNEGKHLY 228 + V V + + GH ++++ VS D L A D + D G+ L Sbjct: 315 RFVVVLDAKTGERLAKFEMGHE--IDSINVSQDEKPLLYALSTGDKTLYIHDAESGEELR 372 Query: 229 TLDGGDIINALCFSPN 244 +N L P Sbjct: 373 ------SVNQLGHGPQ 382 >5AYI-A nrPDB Length = 457 Score = 29.3 bits (64), Expect = 2.5, Method: Composition-based stats. Identities = 8/34 (23%), Positives = 14/34 (41%) Query: 87 LRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQI 120 + +WD + T + G T DV ++ I Sbjct: 32 VSIWDTFSHTPGKIADGTTGDVACDSYHRYGEDI 65 >2FTW-A nrPDB Length = 521 Score = 29.3 bits (64), Expect = 2.5, Method: Composition-based stats. Identities = 13/71 (18%), Positives = 20/71 (28%), Gaps = 1/71 (1%) Query: 36 RDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTG 95 D+ I+W+ + Q S I G DG + +WD Sbjct: 352 EDRMSIVWENGVNTGKLTWCQFVRATSSERARIFNIYPRKGRIDVG-CDGDIVIWDPNQS 410 Query: 96 TTTRRFVGHTK 106 T + H Sbjct: 411 KTISKDTHHHA 421 >1C5K-A nrPDB Length = 439 Score = 29.3 bits (64), Expect = 2.6, Method: Composition-based stats. Identities = 35/211 (16%), Positives = 70/211 (33%), Gaps = 28/211 (13%) Query: 108 VLSVAFSSDNRQ------IVSGSRDKTIKLWNTLGVCKYTVQDESHS------EWVSCVR 155 V V + D + +G T+ N+ V K ++ H+ E ++ ++ Sbjct: 102 VGQVTPNPDGSYNVAYQLVDTGGAPGTVLAQNSYKVNKQWLRYAGHTASDEVFEKLTGIK 161 Query: 156 FSPNSSNPIIV---SCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASG-- 210 + + +V + ++V + H L + SPDGS A Sbjct: 162 GAFRTRIAYVVQTNGGQFPYELRVSDYDGYNQFVVHRS-PQPLMSPAWSPDGSKLAYVTF 220 Query: 211 -GKDGQAMLWDLNEG--KHLYTLDGGDIINALCFSPNRYWLCAATGPS----IKIWDLEG 263 ++ L G + + + + FSP+ L A + + + DL Sbjct: 221 ESGRSALVIQTLANGAVRQVASFPRHNGAP--AFSPDGSKLAFALSKTGSLNLYVMDLAS 278 Query: 264 KIIVDELKQEVISTSSKAEPPQCTSLAWSAD 294 I +T P +LA+++D Sbjct: 279 GQIRQVTDGRSNNTEPT-WFPDSQNLAFTSD 308 >1YJS-A nrPDB Length = 419 Score = 29.3 bits (64), Expect = 2.6, Method: Composition-based stats. Identities = 13/59 (22%), Positives = 23/59 (38%), Gaps = 7/59 (11%) Query: 159 NSSNPIIVSCGWDKLVKVWNLANCKL-------KTNHIGHTGYLNTVTVSPDGSLCASG 210 + +VS G D + + +L +L + +G T NT+ P+ SG Sbjct: 297 QNEGFTLVSGGTDNHLLLVDLRPQQLTGKTAEKVLDEVGITVNKNTIPYDPESPFVTSG 355 >6IDE-A nrPDB Length = 256 Score = 28.9 bits (63), Expect = 2.7, Method: Composition-based stats. Identities = 16/65 (24%), Positives = 25/65 (38%), Gaps = 3/65 (4%) Query: 189 IGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWL 248 GH+ + + PDG A W ++GK T+ G + +W+ Sbjct: 78 TGHSVKVLDIHPYPDGHWHAHI---FTKTPWRDSQGKIQGTIFFGQDLTDTAILEVGHWV 134 Query: 249 CAATG 253 C ATG Sbjct: 135 CRATG 139 >2J04-A nrPDB Length = 588 Score = 28.9 bits (63), Expect = 2.7, Method: Composition-based stats. Identities = 13/113 (11%), Positives = 34/113 (30%), Gaps = 15/113 (13%) Query: 158 PNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYL--NTVTVSPDGSLCASGGKDGQ 215 P+ + + + V V+ + G+ + +P S G +DG+ Sbjct: 93 PSPIDDWMAVLSNNGNVSVFKDNKMLTNLDSKGNLSSRTYHCFEWNPIESSIVVGNEDGE 152 Query: 216 AMLWDLNEGKH------------LYTLDGGDIINALCFSPNRYWLCAATGPSI 256 + + + L D + + + + + A + S+ Sbjct: 153 LQFFSIRKNSENTPEFYFESSIRLSDAGSKDWVTHIVWYED-VLVAALSNNSV 204 >1JOF-A nrPDB Length = 365 Score = 28.9 bits (63), Expect = 2.8, Method: Composition-based stats. Identities = 17/82 (20%), Positives = 26/82 (31%), Gaps = 4/82 (4%) Query: 220 DLNEGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEG-KIIVDELKQEVISTS 278 L + Y I+ + F P +L +A + K+W EL V + Sbjct: 131 KLEKNVQNYEYQENTGIHGMVFDPTETYLYSADLTANKLWTHRKLASGEVELVGSVDAPD 190 Query: 279 SKAEPPQCTSLAWSADGQTLFA 300 P A G L+A Sbjct: 191 PGDHPRWV---AMHPTGNYLYA 209 >1K3I-A nrPDB Length = 656 Score = 28.9 bits (63), Expect = 3.1, Method: Composition-based stats. Identities = 13/71 (18%), Positives = 23/71 (32%), Gaps = 9/71 (12%) Query: 237 NALCFSPNRYWLCAATGPSIKI---WDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSA 293 L +S R + I + WD I+ D + + C ++ Sbjct: 199 RVLMWSSYRNDAFGGSPGGITLTSSWDPSTGIVSDR------TVTVTKHDMFCPGISMDG 252 Query: 294 DGQTLFAGYTD 304 +GQ + G D Sbjct: 253 NGQIVVTGGND 263 >3MUN-A nrPDB Length = 693 Score = 28.9 bits (63), Expect = 3.2, Method: Composition-based stats. Identities = 12/68 (17%), Positives = 26/68 (38%), Gaps = 5/68 (7%) Query: 192 TGYLNTVTVSPDGSLCA-----SGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRY 246 T L+ ++ S DG + A +G + L D+ + L T + + + N Sbjct: 128 TTALDQLSFSRDGRILAYSLSLAGSDWREIHLMDVESKQPLETPLKDVKFSGISWLGNEG 187 Query: 247 WLCAATGP 254 + ++ Sbjct: 188 FFYSSYDK 195 >6IGR-A nrPDB Length = 656 Score = 28.9 bits (63), Expect = 3.3, Method: Composition-based stats. Identities = 22/193 (11%), Positives = 54/193 (27%), Gaps = 48/193 (24%) Query: 50 TNYGIPQRALRGHSHFVSDVVISSDGQFAL-SGSWDGTLR-------------------- 88 G R + + VS S DG+F + + D + Sbjct: 110 PLKGGEARRVTHFKNGVSGPQWSPDGRFIAFTTTADTEDKRDERGEARVLTRPVYRANGA 169 Query: 89 -----------LWDLTTGTTTRRFVGHTKDVLSVAFSSDNR-QIVSGSRDKT-IKLWNTL 135 L+D+ R + + ++++ D+R ++ S D+ W Sbjct: 170 DWLPERPAALWLYDVEADK-LREWYAPEIGIGALSWWPDSRGVLIVQSEDEWQASQWRQD 228 Query: 136 GVCKYTVQDESHSEWVSCVRF-------SPNSSNPII------VSCGWDKLVKVWNLANC 182 ++ + + + +P+ G + ++ + N Sbjct: 229 VYDLPLPTADAPAAPQKLLDWNSAAHGLAPHPDGQRFALIGRPAGKGNTEHAHLYLIENG 288 Query: 183 KLKTNHIGHTGYL 195 + + GH + Sbjct: 289 QHRRLDTGHDHPV 301 >2Z67-A nrPDB Length = 456 Score = 28.1 bits (61), Expect = 4.7, Method: Composition-based stats. Identities = 12/76 (15%), Positives = 29/76 (38%), Gaps = 3/76 (3%) Query: 94 TGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKT---IKLWNTLGVCKYTVQDESHSEW 150 + + H + +V+F N ++V D + + + K ++ + Sbjct: 176 SNVVIYPYASHKSPIKAVSFVGMNMRLVETVLDGDRVYVPVEDIENAIKKEIELGNRPCV 235 Query: 151 VSCVRFSPNSSNPIIV 166 +S + F P ++ IV Sbjct: 236 LSTLTFFPPRNSDDIV 251 >1Z68-A nrPDB Length = 719 Score = 28.1 bits (61), Expect = 4.9, Method: Composition-based stats. Identities = 37/171 (21%), Positives = 57/171 (33%), Gaps = 22/171 (12%) Query: 82 SWDGTLRLWDLTTGTTTRRFVGHT-KDVLSVAF--SSDNRQIVSGSRDKTIKLWNTLGVC 138 S D + L+++ TG + T K V + + S D + + S KLW Sbjct: 33 SADNNIVLYNIETGQSYTILSNRTMKSVNASNYGLSPDRQFVYLESD--YSKLWRYSYTA 90 Query: 139 KYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTV 198 Y + D S+ E+V P + S KL V+ N G + Sbjct: 91 TYYIYDLSNGEFVRGNEL-PRPIQYLCWSPVGSKLAYVY--QNNIYLKQRPG--DPPFQI 145 Query: 199 TVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLC 249 T + + +G D W E AL +SPN +L Sbjct: 146 TFNGRENKIFNGIPD-----WVYEEEMLATKY-------ALWWSPNGKFLA 184 >6FTI-5 nrPDB Length = 705 Score = 27.7 bits (60), Expect = 6.2, Method: Composition-based stats. Identities = 16/88 (18%), Positives = 33/88 (37%), Gaps = 9/88 (10%) Query: 58 ALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTK--DVLSVAFSS 115 HS +V+ SS + DG+ ++D ++ H D +++ Sbjct: 470 TYTFHSTWVTSEAYSSPSIVLSARGGDGSRIIFD--DFREAYYWLRHNTPEDAKVMSWWD 527 Query: 116 DNRQIVSGSRDKTIKL----WNTLGVCK 139 QI + ++TI + WN + + Sbjct: 528 YGYQI-TAMANRTILVDNNTWNNTHISR 554 >4KQP-A nrPDB Length = 232 Score = 27.7 bits (60), Expect = 6.3, Method: Composition-based stats. Identities = 19/94 (20%), Positives = 28/94 (29%), Gaps = 3/94 (3%) Query: 207 CASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFS--PNRYWLCAATGPSIKIWDLEGK 264 A+ D W +GK L +G + L Y + T + L Sbjct: 98 IATSSTDDSIKSWKDLKGKTLGAKNGTASFDYLNAHAKEYGYTVKTFTDATTMYSSLNNG 157 Query: 265 IIVDELKQEV-ISTSSKAEPPQCTSLAWSADGQT 297 I + E I + K T + DGQ Sbjct: 158 SINALMDDEPVIKYAIKQGQKFATPIKPIPDGQY 191 >5OLJ-A nrPDB Length = 723 Score = 27.7 bits (60), Expect = 7.3, Method: Composition-based stats. Identities = 17/77 (22%), Positives = 24/77 (31%), Gaps = 10/77 (12%) Query: 59 LRGHSHFVSDVVISSDGQFALSGSWDG-TLRLWDLTT-------GTTTRRFVGHTKDVLS 110 L H V S DG+ + ++ +D T G G T V Sbjct: 135 LSEHVGKVMIPTFSPDGRMVAFVRDNNIFIKKFDFDTEVQVTTDGQINSVLNGATDWVYE 194 Query: 111 VAFSSDNRQIVSGSRDK 127 F N ++S S D Sbjct: 195 EEFGVTN--LMSWSADN 209 >3THY-A nrPDB Length = 934 Score = 27.4 bits (59), Expect = 7.7, Method: Composition-based stats. Identities = 13/54 (24%), Positives = 22/54 (40%) Query: 5 MTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRA 58 L LKG G A P+ + + +S I +L D++N+G + Sbjct: 239 QDLNRLLKGKKGEQMNSAVLPEMENQVAVSSLSAVIKFLELLSDDSNFGQFELT 292 >2GBG-A nrPDB Length = 730 Score = 27.4 bits (59), Expect = 7.9, Method: Composition-based stats. Identities = 27/182 (14%), Positives = 54/182 (29%), Gaps = 56/182 (30%) Query: 109 LSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTV----QDESHSEWVSCVRFSPNSSNPI 164 S+ + SD+ + ++ I L+N E + +S SP+ + Sbjct: 19 YSLRWVSDSEYLY--KQENNILLFNAEHGNSSIFLENSTFEIFGDSISDYSVSPDRLFVL 76 Query: 165 I-----------VSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKD 213 + + + +++L +L T +T S +G A Sbjct: 77 LEYNYVKQWRHSYTASYS----IYDLNKRQLITEEKIPNNTQW-ITWSQEGHKLA----- 126 Query: 214 GQAMLWD----------------LNEGKHLYTLDGGDII----------NALCFSPNRYW 247 +W + GK +G + +AL +SPN + Sbjct: 127 ---YVWKNDIYVKIEPHLPSHRITSTGKENVIFNGINDWVYEEEIFGAYSALWWSPNGTF 183 Query: 248 LC 249 L Sbjct: 184 LA 185 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.311 0.132 0.377 Lambda K H 0.267 0.0409 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 12,997,615 Number of Sequences: 36641 Number of extensions: 491295 Number of successful extensions: 7279 Number of sequences better than 10.0: 193 Number of HSP's better than 10.0 without gapping: 258 Number of HSP's successfully gapped in prelim test: 73 Number of HSP's that attempted gapping in prelim test: 1412 Number of HSP's gapped (non-prelim): 1565 length of query: 317 length of database: 10,336,785 effective HSP length: 97 effective length of query: 220 effective length of database: 6,782,608 effective search space: 1492173760 effective search space used: 1492173760 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.3 bits) S2: 59 (27.3 bits)