BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P62871 (340 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 5UZ7-B nrPDB 700 0.0 6N9G-C nrPDB 375 e-104 4V7E-Bg nrPDB 308 2e-84 5MZH-A nrPDB 124 7e-29 5NNZ-B nrPDB 120 6e-28 5GAN-H nrPDB 118 5e-27 6QX9-4B nrPDB 115 3e-26 5M25-A nrPDB 115 3e-26 2H9P-A nrPDB 115 4e-26 6F3T-A nrPDB 114 6e-26 6MZM-G nrPDB 113 9e-26 4V8M-A7 nrPDB 105 2e-23 5OPT-p nrPDB 100 2e-21 6G51-g nrPDB 99 2e-21 1VYH-C nrPDB 99 3e-21 6QX9-5O nrPDB 94 1e-19 5Z56-q nrPDB 92 4e-19 3JAP-g nrPDB 91 5e-19 6EOJ-D nrPDB 91 7e-19 6HQA-B nrPDB 91 7e-19 4LG8-A nrPDB 91 1e-18 6GMH-W nrPDB 90 1e-18 5I2T-A nrPDB 87 7e-18 5WLC-LO nrPDB 87 7e-18 5FL8-q nrPDB 87 1e-17 3DM0-A nrPDB 87 1e-17 4V6W-Ag nrPDB 86 2e-17 3JB9-L nrPDB 82 4e-16 6HHQ-h nrPDB 81 8e-16 5Y88-O nrPDB 80 1e-15 6ID0-T nrPDB 79 2e-15 5FVM-C nrPDB 77 1e-14 5WYK-BB nrPDB 75 3e-14 5NZU-C nrPDB 75 4e-14 4GGA-A nrPDB 74 7e-14 6EMK-B nrPDB 74 8e-14 5LCW-Q nrPDB 74 8e-14 5G04-R nrPDB 74 9e-14 4N14-A nrPDB 73 2e-13 3MKQ-A nrPDB 72 3e-13 2YNP-A nrPDB 72 4e-13 5L9T-R nrPDB 72 5e-13 4J0W-A nrPDB 71 8e-13 3FM0-A nrPDB 71 8e-13 4AEZ-A nrPDB 69 2e-12 4BTS-AR nrPDB 69 4e-12 6Q8F-A nrPDB 68 6e-12 5WYJ-BC nrPDB 67 1e-11 6BX3-A nrPDB 65 3e-11 5A31-R nrPDB 65 5e-11 4BH6-A nrPDB 65 5e-11 5K1B-B nrPDB 63 2e-10 6J6H-n nrPDB 63 2e-10 5OQL-L nrPDB 62 4e-10 6QDV-o nrPDB 62 5e-10 5YZG-W nrPDB 61 7e-10 3JB9-g nrPDB 61 8e-10 4U1E-I nrPDB 60 1e-09 5WBU-D nrPDB 60 2e-09 5MWJ-A nrPDB 59 3e-09 5XYI-g nrPDB 58 5e-09 5OQL-J nrPDB 57 1e-08 6CHG-A nrPDB 57 1e-08 5Y1U-A nrPDB 54 1e-07 3ODT-A nrPDB 53 1e-07 3CFV-B nrPDB 53 2e-07 5OQL-d nrPDB 52 2e-07 3C9C-A nrPDB 51 6e-07 5WLC-LU nrPDB 49 3e-06 4L9O-A nrPDB 48 6e-06 2HES-X nrPDB 48 7e-06 4XFV-A nrPDB 47 1e-05 5M89-A nrPDB 47 1e-05 3ACP-A nrPDB 47 2e-05 4OWR-A nrPDB 47 2e-05 5WYJ-BE nrPDB 46 2e-05 5K0Y-T nrPDB 46 2e-05 5WJC-A nrPDB 46 3e-05 4XYI-A nrPDB 46 3e-05 5A9Q-2 nrPDB 45 4e-05 3BG0-A nrPDB 45 4e-05 2PM9-A nrPDB 45 4e-05 6ELZ-p nrPDB 45 4e-05 5BJS-A nrPDB 45 6e-05 4A11-B nrPDB 45 6e-05 5WLC-LJ nrPDB 44 8e-05 1NR0-A nrPDB 44 8e-05 4YCZ-A nrPDB 44 9e-05 5CXC-A nrPDB 43 2e-04 5OQL-X nrPDB 42 4e-04 5WLC-LL nrPDB 42 4e-04 5A9Q-0 nrPDB 42 4e-04 2P9P-C nrPDB 42 5e-04 4G56-B nrPDB 40 0.001 2AQ5-A nrPDB 40 0.002 5WLC-LW nrPDB 40 0.002 4E5Z-B nrPDB 40 0.002 1PI6-A nrPDB 39 0.002 4J0X-A nrPDB 39 0.002 5WLC-SG nrPDB 39 0.003 3JB9-S nrPDB 38 0.005 6E29-D nrPDB 38 0.005 5CXB-B nrPDB 38 0.007 3DW8-B nrPDB 37 0.009 5TF2-A nrPDB 37 0.012 3JRP-A nrPDB 36 0.021 4BZK-B nrPDB 36 0.021 5N4A-A nrPDB 35 0.034 6CB1-s nrPDB 35 0.035 3JRO-A nrPDB 35 0.038 6C0F-s nrPDB 35 0.040 6EM1-m nrPDB 35 0.047 5MC6-j nrPDB 34 0.086 4YHC-A nrPDB 33 0.13 3JZG-A nrPDB 33 0.17 5K19-A nrPDB 33 0.18 6BX3-B nrPDB 33 0.19 5FA5-B nrPDB 33 0.22 1ZUW-A nrPDB 33 0.24 3F3P-A nrPDB 33 0.26 3I2N-A nrPDB 32 0.32 3CLR-D nrPDB 32 0.32 5OV3-A nrPDB 32 0.36 4PSX-B nrPDB 32 0.44 3EI3-B nrPDB 32 0.52 1Z68-A nrPDB 31 0.60 5WLC-LN nrPDB 31 0.68 5AMS-A nrPDB 31 0.68 5GRS-A nrPDB 31 0.82 5YZG-2 nrPDB 31 0.84 3DWL-C nrPDB 30 1.4 3W15-A nrPDB 30 2.1 5WLC-LV nrPDB 29 3.0 5I50-A nrPDB 29 3.1 6CHG-D nrPDB 29 3.2 4JNQ-A nrPDB 28 6.8 2VDU-B nrPDB 28 7.0 5WLC-LH nrPDB 28 7.8 6F1U-h nrPDB 28 7.9 >5UZ7-B nrPDB Length = 351 Score = 700 bits (1807), Expect = 0.0, Method: Compositional matrix adjust. Identities = 339/339 (100%), Positives = 339/339 (100%) Query: 2 SELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAM 61 SELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAM Sbjct: 13 SELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAM 72 Query: 62 HWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNIC 121 HWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNIC Sbjct: 73 HWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNIC 132 Query: 122 SIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFT 181 SIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFT Sbjct: 133 SIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFT 192 Query: 182 GHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAF 241 GHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAF Sbjct: 193 GHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAF 252 Query: 242 ATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALK 301 ATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALK Sbjct: 253 ATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALK 312 Query: 302 ADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 ADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN Sbjct: 313 ADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 351 >6N9G-C nrPDB Length = 353 Score = 375 bits (962), Expect = e-104, Method: Compositional matrix adjust. Identities = 179/341 (52%), Positives = 234/341 (68%), Gaps = 5/341 (1%) Query: 4 LDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHW 63 L L+ EAE LK ++ + R D L Q+ ++ +G+ M+TRRTL+GH K+ M W Sbjct: 12 LASLKSEAESLKGKLEEERAKLHDVELHQVAERVEALGQFVMKTRRTLKGHGNKVLCMDW 71 Query: 64 GTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSI 123 D R +VS+SQDGK+I+WDS+TTNK HA+ + +WVM CAYAPSG +ACGGLDN CS+ Sbjct: 72 CKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSV 131 Query: 124 YNLK--TREGNVRVSRELAGHTGYLSCCRFLD-DNQIVTSSGDTTCALWDIETGQQTTTF 180 Y L E + +A HT YLS C F + D QI+T+SGD TCALWD+E+GQ +F Sbjct: 132 YPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSF 191 Query: 181 TGHTGDVMSLSLAPDT--RLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNG 238 GH DV+ L LAP FVSG CD A +WD+R G C Q F HESD+N++ ++P+G Sbjct: 192 HGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDVNSVRYYPSG 251 Query: 239 NAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWD 298 +AFA+GSDDATCRL+DLRAD+E+ YS ++II G +SV FS SGRLL AGY+D+ NVWD Sbjct: 252 DAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWD 311 Query: 299 ALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIW 339 LK R +L GH+NRVS L V+ DG A +GSWD L++W Sbjct: 312 VLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352 Score = 54.7 bits (130), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 51/215 (23%), Positives = 91/215 (42%), Gaps = 7/215 (3%) Query: 133 VRVSRELAGHTGYLSCCRFLDDNQ-IVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLS 191 ++ R L GH + C + D + IV+SS D +WD T + T VM+ + Sbjct: 53 MKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACA 112 Query: 192 LAPDTRLFVSGACDASAKLW----DVREGMC--RQTFTGHESDINAICFFPNGNAFATGS 245 AP G D ++ D E M +++ H + ++A F + T S Sbjct: 113 YAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTAS 172 Query: 246 DDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRA 305 D TC L+D+ + Q L ++ ++ S++G ++G D VWD Sbjct: 173 GDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCV 232 Query: 306 GVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 H++ V+ + G A A+GS D+ ++++ Sbjct: 233 QAFETHESDVNSVRYYPSGDAFASGSDDATCRLYD 267 >4V7E-Bg nrPDB Length = 380 Score = 308 bits (790), Expect = 2e-84, Method: Compositional matrix adjust. Identities = 155/312 (49%), Positives = 213/312 (68%), Gaps = 21/312 (6%) Query: 49 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPS 108 RTL+GH K+Y++ W + +VSASQDG+LI+W++ T+ K HAI L WVM CA+AP+ Sbjct: 60 RTLQGHSGKVYSLDWTPEKNWIVSASQDGRLIVWNALTSQKTHAIKLHCPWVMECAFAPN 119 Query: 109 GNYVACGGLDNICSIYNLKT---REGNVRVSRELAGHTGYLSCCRFLDDNQ--IVTSSGD 163 G VACGGLD+ CSI+NL + R+GN+ VSR L GH GY S C+++ D + ++T SGD Sbjct: 120 GQSVACGGLDSACSIFNLSSQADRDGNMPVSRVLTGHKGYASSCQYVPDQETRLITGSGD 179 Query: 164 TTCALWDIETGQQTTTF-----TGHTGDVMSLSL-APDTRLFVSGACDASAKLWDVR-EG 216 TC LWD+ TGQ+ + F +GHT DV+SLS+ + + +F+SG+CD + +LWD+R Sbjct: 180 QTCVLWDVTTGQRISIFGSEFPSGHTADVLSLSINSLNANMFISGSCDTTVRLWDLRITS 239 Query: 217 MCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYS-----HDNIIC 271 +T+ GHE DIN++ FFP+G F TGSDD TCRLFD+R +L Y+ +DN + Sbjct: 240 RAVRTYHGHEGDINSVKFFPDGQRFGTGSDDGTCRLFDMRTGHQLQVYNREPDRNDNELP 299 Query: 272 GITSVSFSKSGRLLLAGYDDFNCNVWDALKADRA---GVLA-GHDNRVSCLGVTDDGMAV 327 +TSV+FS SGRLL AGY + +C VWD L A+ G L H+ R+SCLG++ DG A+ Sbjct: 300 IVTSVAFSISGRLLFAGYSNGDCYVWDTLLAEMVLNLGTLQNSHEGRISCLGLSSDGSAL 359 Query: 328 ATGSWDSFLKIW 339 TGSWD LKIW Sbjct: 360 CTGSWDKNLKIW 371 Score = 58.5 bits (140), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 53/218 (24%), Positives = 98/218 (44%), Gaps = 14/218 (6%) Query: 137 RELAGHTGYLSCCRFL-DDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPD 195 R L GH+G + + + N IV++S D +W+ T Q+T H VM + AP+ Sbjct: 60 RTLQGHSGKVYSLDWTPEKNWIVSASQDGRLIVWNALTSQKTHAIKLHCPWVMECAFAPN 119 Query: 196 TRLFVSGACDASAKLWDV-----REG--MCRQTFTGHESDINAICFFPNGNA-FATGSDD 247 + G D++ ++++ R+G + TGH+ ++ + P+ TGS D Sbjct: 120 GQSVACGGLDSACSIFNLSSQADRDGNMPVSRVLTGHKGYASSCQYVPDQETRLITGSGD 179 Query: 248 ATCRLFDLRADQELMTYSHD---NIICGITSVSF-SKSGRLLLAGYDDFNCNVWDALKAD 303 TC L+D+ Q + + + + S+S S + + ++G D +WD Sbjct: 180 QTCVLWDVTTGQRISIFGSEFPSGHTADVLSLSINSLNANMFISGSCDTTVRLWDLRITS 239 Query: 304 RA-GVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 RA GH+ ++ + DG TGS D ++++ Sbjct: 240 RAVRTYHGHEGDINSVKFFPDGQRFGTGSDDGTCRLFD 277 >5MZH-A nrPDB Length = 452 Score = 124 bits (310), Expect = 7e-29, Method: Compositional matrix adjust. Identities = 77/295 (26%), Positives = 138/295 (46%), Gaps = 10/295 (3%) Query: 49 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYA-P 107 + LR H+ + + ++ S D +W+++T +V + + V A+ P Sbjct: 88 KVLRAHILPLTNCAFNKSGDRFITGSYDRTCKVWNTFTGEEVFTLEGHKNVVYAIAFNNP 147 Query: 108 SGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIV-TSSGDTTC 166 G+ + G D C +++ T + + L GH + C F + I+ T S D T Sbjct: 148 YGDKIVTGSFDKTCKLWDAYTGQ----LYYTLKGHQTEIVCLSFNPQSTIIATGSMDNTA 203 Query: 167 ALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHE 226 LWD+ETGQ+ T GH +++SL L V+G+ D ++LWDVR G C +GH Sbjct: 204 KLWDVETGQERATLAGHRAEIVSLGFNTGGDLIVTGSFDHDSRLWDVRTGQCVHVLSGHR 263 Query: 227 SDINAICFFPNGNAFATGSDDATCRLFDLRADQEL-MTYSHDNIICGITSVSFSKSGRLL 285 ++++ F G +GS D T RL+D+R+ + L + H + + V+F +G + Sbjct: 264 GEVSSTQFNYAGTLVVSGSIDCTSRLWDVRSGRCLSVKQGHTD---EVLDVAFDAAGTKM 320 Query: 286 LAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 ++ D + ++ L L GH+ +S + G + T S D ++W+ Sbjct: 321 VSASADGSARLYHTLTGVCQHTLVGHEGEISKVAFNPQGTRLITASSDKTCRLWD 375 Score = 116 bits (291), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 81/262 (30%), Positives = 124/262 (47%), Gaps = 16/262 (6%) Query: 84 SYTTNKV---HAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELA 140 S+T KV H +PL + CA+ SG+ G D C ++N T E L Sbjct: 83 SFTLFKVLRAHILPLTN-----CAFNKSGDRFITGSYDRTCKVWNTFTGEEVF----TLE 133 Query: 141 GHTGYLSCCRFLDD--NQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRL 198 GH + F + ++IVT S D TC LWD TGQ T GH +++ LS P + + Sbjct: 134 GHKNVVYAIAFNNPYGDKIVTGSFDKTCKLWDAYTGQLYYTLKGHQTEIVCLSFNPQSTI 193 Query: 199 FVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRAD 258 +G+ D +AKLWDV G R T GH ++I ++ F G+ TGS D RL+D+R Sbjct: 194 IATGSMDNTAKLWDVETGQERATLAGHRAEIVSLGFNTGGDLIVTGSFDHDSRLWDVRTG 253 Query: 259 QELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCL 318 Q + S ++S F+ +G L+++G D +WD V GH + V + Sbjct: 254 QCVHVLSGHR--GEVSSTQFNYAGTLVVSGSIDCTSRLWDVRSGRCLSVKQGHTDEVLDV 311 Query: 319 GVTDDGMAVATGSWDSFLKIWN 340 G + + S D ++++ Sbjct: 312 AFDAAGTKMVSASADGSARLYH 333 Score = 115 bits (287), Expect = 4e-26, Method: Compositional matrix adjust. Identities = 69/256 (26%), Positives = 124/256 (48%), Gaps = 11/256 (4%) Query: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109 TL+GH +I + + S ++ + S D +WD T + + + +++ + G Sbjct: 174 TLKGHQTEIVCLSFNPQSTIIATGSMDNTAKLWDVETGQERATLAGHRAEIVSLGFNTGG 233 Query: 110 NYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRF-LDDNQIVTSSGDTTCAL 168 + + G D+ +++++T + L+GH G +S +F +V+ S D T L Sbjct: 234 DLIVTGSFDHDSRLWDVRTGQ----CVHVLSGHRGEVSSTQFNYAGTLVVSGSIDCTSRL 289 Query: 169 WDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESD 228 WD+ +G+ + GHT +V+ ++ VS + D SA+L+ G+C+ T GHE + Sbjct: 290 WDVRSGRCLSVKQGHTDEVLDVAFDAAGTKMVSASADGSARLYHTLTGVCQHTLVGHEGE 349 Query: 229 INAICFFPNGNAFATGSDDATCRLFDLRADQ--ELMTYSHDNIICGITSVSFSKSGRLLL 286 I+ + F P G T S D TCRL+D + +++ D I S +F+ G ++ Sbjct: 350 ISKVAFNPQGTRLITASSDKTCRLWDCDTGECLQVLEGHTDEIF----SCAFNYEGDFII 405 Query: 287 AGYDDFNCNVWDALKA 302 G D C +W AL A Sbjct: 406 TGSKDNTCRIWKALTA 421 Score = 43.9 bits (102), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 36/142 (25%), Positives = 64/142 (45%), Gaps = 9/142 (6%) Query: 33 ITNNIDPVGRI-QMRTRRTL---RGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTN 88 ++ +ID R+ +R+ R L +GH ++ + + +VSAS DG ++ + T Sbjct: 279 VSGSIDCTSRLWDVRSGRCLSVKQGHTDEVLDVAFDAAGTKMVSASADGSARLYHTLTGV 338 Query: 89 KVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSC 148 H + + A+ P G + D C +++ T E + L GHT + Sbjct: 339 CQHTLVGHEGEISKVAFNPQGTRLITASSDKTCRLWDCDTGE----CLQVLEGHTDEIFS 394 Query: 149 CRF-LDDNQIVTSSGDTTCALW 169 C F + + I+T S D TC +W Sbjct: 395 CAFNYEGDFIITGSKDNTCRIW 416 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 21/81 (25%), Positives = 38/81 (46%) Query: 48 RRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAP 107 + TL GH +I + + L++AS D +WD T + + + + +CA+ Sbjct: 340 QHTLVGHEGEISKVAFNPQGTRLITASSDKTCRLWDCDTGECLQVLEGHTDEIFSCAFNY 399 Query: 108 SGNYVACGGLDNICSIYNLKT 128 G+++ G DN C I+ T Sbjct: 400 EGDFIITGSKDNTCRIWKALT 420 >5NNZ-B nrPDB Length = 415 Score = 120 bits (302), Expect = 6e-28, Method: Compositional matrix adjust. Identities = 83/293 (28%), Positives = 130/293 (44%), Gaps = 10/293 (3%) Query: 50 TLRGHLAKIYAMHWGTD-SRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPS 108 TL GH +YA+ + + + S D +W T H ++ ++ ++ P Sbjct: 129 TLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQ 188 Query: 109 GNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRF-LDDNQIVTSSGDTTCA 167 VA G +D +++++ N L GH+ + F ++I+T S D T Sbjct: 189 STLVATGSMDTTAKLWDIQ----NGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVV 244 Query: 168 LWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHES 227 +WD +TG++ GH ++ S S D L ++G+ D + KLWD G C T TGH+ Sbjct: 245 VWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDD 304 Query: 228 DINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYS-HDNIICGITSVSFSKSGRLLL 286 +I CF G AT S D T R+F + + H+ I+ +SF+ G LL Sbjct: 305 EILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEG---EISKISFNPQGNHLL 361 Query: 287 AGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIW 339 G D +WDA VL GH + + G V TGS D+ +IW Sbjct: 362 TGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414 Score = 119 bits (298), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 85/264 (32%), Positives = 129/264 (48%), Gaps = 33/264 (12%) Query: 89 KVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYN------LKTREGNVRVSRELAGH 142 K H +PL + A SG+ G D C +++ L T EG+ V +A + Sbjct: 89 KAHILPLTN-----VALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFN 143 Query: 143 TGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSG 202 Y ++I T S D TC LW +ETG+ TF GHT +++ LS P + L +G Sbjct: 144 NPY--------GDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATG 195 Query: 203 ACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELM 262 + D +AKLWD++ G T GH ++I ++ F +G+ TGS D T ++D +++ Sbjct: 196 SMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKV- 254 Query: 263 TYSHDNIICG----ITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRV--S 316 NI+ G I+S SF+ L+L G D C +WDA L GHD+ + S Sbjct: 255 -----NILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDS 309 Query: 317 CLGVTDDGMAVATGSWDSFLKIWN 340 C T G +AT S D +I++ Sbjct: 310 CFDYT--GKLIATASADGTARIFS 331 Score = 114 bits (284), Expect = 8e-26, Method: Compositional matrix adjust. Identities = 71/253 (28%), Positives = 122/253 (48%), Gaps = 13/253 (5%) Query: 49 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPS 108 T RGH A+I + + S L+ + S D +WD +V+ + S+ +++ ++ S Sbjct: 171 HTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTS 230 Query: 109 GNYVACGGLDNICSIYNLKT-REGNVRVSRELAGHTGYLSCCRF-LDDNQIVTSSGDTTC 166 G+ + G D+ +++ T R+ N+ L GH +S F D + I+T S D TC Sbjct: 231 GDRIITGSFDHTVVVWDADTGRKVNI-----LIGHCAEISSASFNWDCSLILTGSMDKTC 285 Query: 167 ALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHE 226 LWD G+ T TGH +++ +L + + D +A+++ C GHE Sbjct: 286 KLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHE 345 Query: 227 SDINAICFFPNGNAFATGSDDATCRLFDLRADQ--ELMTYSHDNIICGITSVSFSKSGRL 284 +I+ I F P GN TGS D T R++D + Q +++ D I S +F+ G + Sbjct: 346 GEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIF----SCAFNYKGNI 401 Query: 285 LLAGYDDFNCNVW 297 ++ G D C +W Sbjct: 402 VITGSKDNTCRIW 414 Score = 109 bits (272), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 74/295 (25%), Positives = 136/295 (46%), Gaps = 10/295 (3%) Query: 49 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYA-P 107 + L+ H+ + + ++ S D +WD+ + +++ + + V A+ P Sbjct: 86 KVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNP 145 Query: 108 SGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIV-TSSGDTTC 166 G+ +A G D C +++++T + GHT + C F + +V T S DTT Sbjct: 146 YGDKIATGSFDKTCKLWSVETG----KCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTA 201 Query: 167 ALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHE 226 LWDI+ G++ T GH+ +++SLS ++G+ D + +WD G GH Sbjct: 202 KLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHC 261 Query: 227 SDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYS-HDNIICGITSVSFSKSGRLL 285 ++I++ F + + TGS D TC+L+D + + T + HD+ I F +G+L+ Sbjct: 262 AEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDD---EILDSCFDYTGKLI 318 Query: 286 LAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 D ++ A L GH+ +S + G + TGS D +IW+ Sbjct: 319 ATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWD 373 >5GAN-H nrPDB Length = 465 Score = 118 bits (295), Expect = 5e-27, Method: Compositional matrix adjust. Identities = 84/293 (28%), Positives = 136/293 (46%), Gaps = 15/293 (5%) Query: 58 IYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKV-HAIPLRSSWVMTCAYAPSGN--YVAC 114 I A+ TD ++ + S G L + +S T + + + + P N ++C Sbjct: 178 ISAVSLSTDDMVVATGSWAGDLQVLNSQTLQPLTQKLDSHVGKIGAIDWHPDSNNQMISC 237 Query: 115 GGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIV-TSSGDTTCALWDIET 173 D + + EG +R+ +L GH +S ++ + + ++S D T LWD T Sbjct: 238 AE-DGLIKNFQYSNEEGGLRLLGDLVGHERRISDVKYHPSGKFIGSASHDMTWRLWDAST 296 Query: 174 GQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAIC 233 Q+ GH V SLS D L SG D+ + LWD+R G T GH I + Sbjct: 297 HQELLLQEGHDKGVFSLSFQCDGSLVCSGGMDSLSMLWDIRSGSKVMTLAGHSKPIYTVA 356 Query: 234 FFPNGNAFATGSDDATCRLFDLRADQE---LMTYSHDNIICGITSVSFSKS---GRLLLA 287 + PNG ATG D ++D+R E +H NI +T V FSK +L+ Sbjct: 357 WSPNGYQVATGGGDGIINVWDIRKRDEGQLNQILAHRNI---VTQVRFSKEDGGKKLVSC 413 Query: 288 GYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 GYD+ NV+ + + G LAGH +++ L ++++ + +G WD +K+WN Sbjct: 414 GYDNL-INVYSSDTWLKMGSLAGHTDKIISLDISNNSHFLVSGGWDRSIKLWN 465 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 43/165 (26%), Positives = 86/165 (52%), Gaps = 7/165 (4%) Query: 52 RGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNY 111 GH ++++ + D L+ S D ++WD + +KV + S + T A++P+G Sbjct: 304 EGHDKGVFSLSFQCDGSLVCSGGMDSLSMLWDIRSGSKVMTLAGHSKPIYTVAWSPNGYQ 363 Query: 112 VACGGLDNICSIYNLKTR-EGNVRVSRELAGHTGYLSCCRFLDDN---QIVTSSGDTTCA 167 VA GG D I ++++++ R EG + ++ H ++ RF ++ ++V+ D Sbjct: 364 VATGGGDGIINVWDIRKRDEGQL---NQILAHRNIVTQVRFSKEDGGKKLVSCGYDNLIN 420 Query: 168 LWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWD 212 ++ +T + + GHT ++SL ++ ++ VSG D S KLW+ Sbjct: 421 VYSSDTWLKMGSLAGHTDKIISLDISNNSHFLVSGGWDRSIKLWN 465 >6QX9-4B nrPDB Length = 522 Score = 115 bits (288), Expect = 3e-26, Method: Compositional matrix adjust. Identities = 84/295 (28%), Positives = 133/295 (45%), Gaps = 30/295 (10%) Query: 62 HWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSG---------NYV 112 H+ +S++L +A G +W N +H + ++ V + P N Sbjct: 238 HFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLA 297 Query: 113 ACGGLDNICSIYNLKTREG-------NVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTT 165 +C D +++L + E VRV+R + +G RFL T+ D + Sbjct: 298 SCAA-DGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSG-----RFLG-----TTCYDRS 346 Query: 166 CALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGH 225 LWD+E ++ GH+ V ++ D L +G DA ++WD+R G C GH Sbjct: 347 WRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGH 406 Query: 226 ESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTY-SHDNIICGITSVSFSKSGRL 284 +I I F PNG ATGS D TC+++DLR + + T +H N++ G+ G Sbjct: 407 LKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPI--HGNF 464 Query: 285 LLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIW 339 LL G D +W LAGH+ +V L ++ DG +AT S+D K+W Sbjct: 465 LLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 51/204 (25%), Positives = 88/204 (43%), Gaps = 11/204 (5%) Query: 146 LSCCRFLDDNQIV-TSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRL------ 198 +S C F +++++ T+ C LW + T GH +V ++ P + + Sbjct: 234 ISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKD 293 Query: 199 --FVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLR 256 S A D S KLW + GH + + + P+G T D + RL+DL Sbjct: 294 VNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLE 353 Query: 257 ADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVS 316 A +E++ ++ G+ ++F + G L G D VWD L GH + Sbjct: 354 AQEEILHQEGHSM--GVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIY 411 Query: 317 CLGVTDDGMAVATGSWDSFLKIWN 340 + + +G +ATGS D+ K+W+ Sbjct: 412 GINFSPNGYHIATGSGDNTCKVWD 435 Score = 71.6 bits (174), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 53/205 (25%), Positives = 83/205 (40%), Gaps = 6/205 (2%) Query: 51 LRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGN 110 + GH ++ + W R L + D +WD ++ S V A+ G+ Sbjct: 319 IEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGS 378 Query: 111 YVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDN-QIVTSSGDTTCALW 169 GGLD +++L+T R L GH + F + I T SGD TC +W Sbjct: 379 LAGTGGLDAFGRVWDLRTG----RCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVW 434 Query: 170 DIETGQQTTTFTGHTGDVMSLSLAP-DTRLFVSGACDASAKLWDVREGMCRQTFTGHESD 228 D+ + T H V + P ++GA D +AK+W +T GHE Sbjct: 435 DLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGK 494 Query: 229 INAICFFPNGNAFATGSDDATCRLF 253 + + +G AT S D T +L+ Sbjct: 495 VMGLDISSDGQLIATCSYDRTFKLW 519 >5M25-A nrPDB Length = 434 Score = 115 bits (287), Expect = 3e-26, Method: Compositional matrix adjust. Identities = 72/246 (29%), Positives = 121/246 (49%), Gaps = 11/246 (4%) Query: 100 VMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHT-GYLSCCRFLDDNQIV 158 V + ++P+G ++A D + I+ +G + + ++GH G D N +V Sbjct: 148 VSSVKFSPNGEWLASSSADKLIKIWG--AYDG--KFEKTISGHKLGISDVAWSSDSNLLV 203 Query: 159 TSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMC 218 ++S D T +WD+ +G+ T GH+ V + P + L VSG+ D S ++WDV+ G C Sbjct: 204 SASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKC 263 Query: 219 RQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSF 278 +T H ++A+ F +G+ + S D CR++D + Q L T D+ ++ V F Sbjct: 264 LKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDD-NPPVSFVKF 322 Query: 279 SKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCL----GVTDDGMAVATGSWDS 334 S +G+ +LA D +WD K GH N C+ VT G + +GS D+ Sbjct: 323 SPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVT-GGKWIVSGSEDN 381 Query: 335 FLKIWN 340 + IWN Sbjct: 382 LVYIWN 387 Score = 106 bits (264), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 65/221 (29%), Positives = 109/221 (49%), Gaps = 13/221 (5%) Query: 46 RTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAY 105 + +T+ GH I + W +DS LLVSAS D L IWD + + + S++V C + Sbjct: 178 KFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNF 237 Query: 106 APSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRF-LDDNQIVTSSGDT 164 P N + G D I+++KT + + L H+ +S F D + IV+SS D Sbjct: 238 NPQSNLIVSGSFDESVRIWDVKTG----KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDG 293 Query: 165 TCALWDIETGQQTTTFTGHTGDVMS-LSLAPDTRLFVSGACDASAKLWDVREGMCRQTFT 223 C +WD +GQ T +S + +P+ + ++ D + KLWD +G C +T+T Sbjct: 294 LCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYT 353 Query: 224 GHESDINAICFFPN-----GNAFATGSDDATCRLFDLRADQ 259 GH+++ C F N G +GS+D +++L+ + Sbjct: 354 GHKNE--KYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKE 392 Score = 100 bits (249), Expect = 8e-22, Method: Compositional matrix adjust. Identities = 82/344 (23%), Positives = 153/344 (44%), Gaps = 14/344 (4%) Query: 3 ELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMH 62 + DQ ++ + N I +A + + +Q + PV + + TL GH + ++ Sbjct: 96 QADQTPEDLDMEDNDIIEAHREQIGGSATQ--SKPTPV-KPNYALKFTLAGHTKAVSSVK 152 Query: 63 WGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICS 122 + + L S+S D + IW +Y I + A++ N + D Sbjct: 153 FSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLK 212 Query: 123 IYNLKTREGNVRVSRELAGHTGYLSCCRF-LDDNQIVTSSGDTTCALWDIETGQQTTTFT 181 I+++ + + + L GH+ Y+ CC F N IV+ S D + +WD++TG+ T Sbjct: 213 IWDVSSG----KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLP 268 Query: 182 GHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHES-DINAICFFPNGNA 240 H+ V ++ D L VS + D ++WD G C +T ++ ++ + F PNG Sbjct: 269 AHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKY 328 Query: 241 FATGSDDATCRLFDLRADQELMTYS-HDN-IICGITSVSFSKSGRLLLAGYDDFNCNVWD 298 + D T +L+D + L TY+ H N C + S + G+ +++G +D +W+ Sbjct: 329 ILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVT-GGKWIVSGSEDNLVYIWN 387 Query: 299 ALKADRAGVLAGHDNRV--SCLGVTDDGMAVATGSWDSFLKIWN 340 + L GH + V + T++ +A A D +K+W Sbjct: 388 LQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 431 >2H9P-A nrPDB Length = 329 Score = 115 bits (287), Expect = 4e-26, Method: Compositional matrix adjust. Identities = 70/245 (28%), Positives = 119/245 (48%), Gaps = 9/245 (3%) Query: 100 VMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHT-GYLSCCRFLDDNQIV 158 V + ++P+G ++A D + I+ +G + + ++GH G D N +V Sbjct: 43 VSSVKFSPNGEWLASSSADKLIKIWG--AYDG--KFEKTISGHKLGISDVAWSSDSNLLV 98 Query: 159 TSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMC 218 ++S D T +WD+ +G+ T GH+ V + P + L VSG+ D S ++WDV+ G C Sbjct: 99 SASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKC 158 Query: 219 RQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSF 278 +T H ++A+ F +G+ + S D CR++D + Q L T D+ ++ V F Sbjct: 159 LKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNP-PVSFVKF 217 Query: 279 SKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGV---TDDGMAVATGSWDSF 335 S +G+ +LA D +WD K GH N C+ G + +GS D+ Sbjct: 218 SPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNL 277 Query: 336 LKIWN 340 + IWN Sbjct: 278 VYIWN 282 Score = 106 bits (265), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 66/226 (29%), Positives = 110/226 (48%), Gaps = 13/226 (5%) Query: 41 GRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWV 100 G + +T+ GH I + W +DS LLVSAS D L IWD + + + S++V Sbjct: 68 GAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYV 127 Query: 101 MTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRF-LDDNQIVT 159 C + P N + G D I+++KT + + L H+ +S F D + IV+ Sbjct: 128 FCCNFNPQSNLIVSGSFDESVRIWDVKTG----KCLKTLPAHSDPVSAVHFNRDGSLIVS 183 Query: 160 SSGDTTCALWDIETGQQTTTFTGHTGDVMS-LSLAPDTRLFVSGACDASAKLWDVREGMC 218 SS D C +WD +GQ T +S + +P+ + ++ D + KLWD +G C Sbjct: 184 SSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKC 243 Query: 219 RQTFTGHESDINAICFFPN-----GNAFATGSDDATCRLFDLRADQ 259 +T+TGH+++ C F N G +GS+D +++L+ + Sbjct: 244 LKTYTGHKNE--KYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKE 287 Score = 98.2 bits (243), Expect = 5e-21, Method: Compositional matrix adjust. Identities = 73/297 (24%), Positives = 133/297 (44%), Gaps = 9/297 (3%) Query: 48 RRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAP 107 + TL GH + ++ + + L S+S D + IW +Y I + A++ Sbjct: 33 KFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSS 92 Query: 108 SGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRF-LDDNQIVTSSGDTTC 166 N + D I+++ + + + L GH+ Y+ CC F N IV+ S D + Sbjct: 93 DSNLLVSASDDKTLKIWDVSSG----KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESV 148 Query: 167 ALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHE 226 +WD++TG+ T H+ V ++ D L VS + D ++WD G C +T + Sbjct: 149 RIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDD 208 Query: 227 S-DINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYS-HDNIICGITSVSFSKSGRL 284 + ++ + F PNG + D T +L+D + L TY+ H N I + G+ Sbjct: 209 NPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKW 268 Query: 285 LLAGYDDFNCNVWDALKADRAGVLAGHDNRV--SCLGVTDDGMAVATGSWDSFLKIW 339 +++G +D +W+ + L GH + V + T++ +A A D +K+W Sbjct: 269 IVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 325 Score = 75.5 bits (184), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 43/164 (26%), Positives = 78/164 (47%), Gaps = 6/164 (3%) Query: 179 TFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNG 238 T GHT V S+ +P+ S + D K+W +G +T +GH+ I+ + + + Sbjct: 35 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 94 Query: 239 NAFATGSDDATCRLFDLRADQELMTYS-HDN-IICGITSVSFSKSGRLLLAGYDDFNCNV 296 N + SDD T +++D+ + + L T H N + C +F+ L+++G D + + Sbjct: 95 NLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFC----CNFNPQSNLIVSGSFDESVRI 150 Query: 297 WDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 WD L H + VS + DG + + S+D +IW+ Sbjct: 151 WDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 194 >6F3T-A nrPDB Length = 608 Score = 114 bits (285), Expect = 6e-26, Method: Compositional matrix adjust. Identities = 73/247 (29%), Positives = 116/247 (46%), Gaps = 19/247 (7%) Query: 49 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTN-----KVHAIPLRSSWVMTC 103 + L GH +Y + D L+S+S+DG + +W T K H P V Sbjct: 345 KILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYP-----VWDT 399 Query: 104 AYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRF-LDDNQIVTSSG 162 ++P G Y GG D + ++ + + R AGH ++C RF + N + T S Sbjct: 400 QFSPYGYYFVSGGHDRVARLWATD----HYQPLRIFAGHLADVNCTRFHPNSNYVATGSA 455 Query: 163 DTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTF 222 D T LWD+ G FTGH G + SL+ +P+ R +GA D LWD+ G+ Sbjct: 456 DRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGEL 515 Query: 223 TGHESDINAICFFPNGNAFATGSDDATCRLFD-LRADQELMTYSHDNIICGITSVSFSKS 281 GH + ++ F +G A+GS D T RL+D ++A ++L T D+ ++ ++ Sbjct: 516 KGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLET---DDFTTATGHINLPEN 572 Query: 282 GRLLLAG 288 + LL G Sbjct: 573 SQELLLG 579 Score = 107 bits (266), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 68/203 (33%), Positives = 99/203 (48%), Gaps = 3/203 (1%) Query: 139 LAGHTGYLSCCRFLDD-NQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTR 197 L GH+G + F D N +++SS D T LW ++T + GH V +P Sbjct: 347 LYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGY 406 Query: 198 LFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRA 257 FVSG D A+LW + F GH +D+N F PN N ATGS D T RL+D+ Sbjct: 407 YFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLN 466 Query: 258 DQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSC 317 + ++ I S++FS +GR L G D +WD G L GH + V Sbjct: 467 GNCVRIFTGHK--GPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCS 524 Query: 318 LGVTDDGMAVATGSWDSFLKIWN 340 L + DG +A+GS D+ +++W+ Sbjct: 525 LRFSRDGEILASGSMDNTVRLWD 547 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 56/249 (22%), Positives = 95/249 (38%), Gaps = 28/249 (11%) Query: 106 APSGNYVACGGL---DNICSIYNLKTREGNVRVSRE----------LAGHTGYLSCCRFL 152 AP N + L D + I N+K VR+ + L + G L+ Sbjct: 229 APPQNRIPLPELKDSDKLDKIMNMKETTKRVRLGPDCLPSICFYTFLNAYQG-LTAVDVT 287 Query: 153 DDNQIVTSS-GDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLW 211 DD+ ++ D+T +W + + + S+ A D L + D ++ Sbjct: 288 DDSSLIAGGFADSTVRVWSVTPKK-----------LRSVKQASDLSLIDKESDDVLERIM 336 Query: 212 DVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIIC 271 D + + GH + F P+ N + S+D T RL+ L+ L+ Y N Sbjct: 337 DEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNY-- 394 Query: 272 GITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGS 331 + FS G ++G D +W + AGH V+C + VATGS Sbjct: 395 PVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGS 454 Query: 332 WDSFLKIWN 340 D +++W+ Sbjct: 455 ADRTVRLWD 463 >6MZM-G nrPDB Length = 800 Score = 113 bits (283), Expect = 9e-26, Method: Compositional matrix adjust. Identities = 73/247 (29%), Positives = 116/247 (46%), Gaps = 19/247 (7%) Query: 49 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTN-----KVHAIPLRSSWVMTC 103 + L GH +Y + D L+S+S+DG + +W T K H P V Sbjct: 537 KILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYP-----VWDT 591 Query: 104 AYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRF-LDDNQIVTSSG 162 ++P G Y GG D + ++ + + R AGH ++C RF + N + T S Sbjct: 592 QFSPYGYYFVSGGHDRVARLWATD----HYQPLRIFAGHLADVNCTRFHPNSNYVATGSA 647 Query: 163 DTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTF 222 D T LWD+ G FTGH G + SL+ +P+ R +GA D LWD+ G+ Sbjct: 648 DRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGEL 707 Query: 223 TGHESDINAICFFPNGNAFATGSDDATCRLFD-LRADQELMTYSHDNIICGITSVSFSKS 281 GH + ++ F +G A+GS D T RL+D ++A ++L T D+ ++ ++ Sbjct: 708 KGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLET---DDFTTATGHINLPEN 764 Query: 282 GRLLLAG 288 + LL G Sbjct: 765 SQELLLG 771 Score = 106 bits (265), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 68/203 (33%), Positives = 99/203 (48%), Gaps = 3/203 (1%) Query: 139 LAGHTGYLSCCRFLDD-NQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTR 197 L GH+G + F D N +++SS D T LW ++T + GH V +P Sbjct: 539 LYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGY 598 Query: 198 LFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRA 257 FVSG D A+LW + F GH +D+N F PN N ATGS D T RL+D+ Sbjct: 599 YFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLN 658 Query: 258 DQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSC 317 + ++ I S++FS +GR L G D +WD G L GH + V Sbjct: 659 GNCVRIFTGHK--GPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCS 716 Query: 318 LGVTDDGMAVATGSWDSFLKIWN 340 L + DG +A+GS D+ +++W+ Sbjct: 717 LRFSRDGEILASGSMDNTVRLWD 739 >4V8M-A7 nrPDB Length = 318 Score = 105 bits (263), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 74/257 (28%), Positives = 118/257 (45%), Gaps = 13/257 (5%) Query: 49 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPS 108 R L GH A + + + VSAS D L +W+ + + V++ A++P Sbjct: 61 RRLEGHSAFVSDVALSNNGNFAVSASWDHSLRLWNLQNGQCQYKFLGHTKDVLSVAFSPD 120 Query: 109 GNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRF---LDDNQIVTSSGDTT 165 + GG DN ++N+K G + HT ++SC RF LD IV+ D Sbjct: 121 NRQIVSGGRDNALRVWNVK---GECMHTLSRGAHTDWVSCVRFSPSLDAPVIVSGGWDNL 177 Query: 166 CALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGH 225 +WD+ TG+ T GHT V S++++PD L S D A+LWD+ +G Sbjct: 178 VKVWDLATGRLVTDLKGHTNYVTSVTVSPDGSLCASSDKDGVARLWDLTKGEALSEMAA- 236 Query: 226 ESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDN-----IICGITSVSFSK 280 + IN ICF PN + + + R+FDL ++ + ++ I+ S+++S Sbjct: 237 GAPINQICFSPN-RYWMCAATEKGIRIFDLENKDIIVELAPEHQGSKKIVPECVSIAWSA 295 Query: 281 SGRLLLAGYDDFNCNVW 297 G L +GY D VW Sbjct: 296 DGSTLYSGYTDNVIRVW 312 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 56/180 (31%), Positives = 93/180 (51%), Gaps = 12/180 (6%) Query: 137 RELAGHTGYLSCCRFLDD-NQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPD 195 R L GH+ ++S ++ N V++S D + LW+++ GQ F GHT DV+S++ +PD Sbjct: 61 RRLEGHSAFVSDVALSNNGNFAVSASWDHSLRLWNLQNGQCQYKFLGHTKDVLSVAFSPD 120 Query: 196 TRLFVSGACDASAKLWDVREGMCRQTFT--GHESDINAICFFPNGNA--FATGSDDATCR 251 R VSG D + ++W+V+ G C T + H ++ + F P+ +A +G D + Sbjct: 121 NRQIVSGGRDNALRVWNVK-GECMHTLSRGAHTDWVSCVRFSPSLDAPVIVSGGWDNLVK 179 Query: 252 LFDLRADQELMT--YSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLA 309 ++DL A L+T H N +TSV+ S G L + D +WD K + +A Sbjct: 180 VWDL-ATGRLVTDLKGHTNY---VTSVTVSPDGSLCASSDKDGVARLWDLTKGEALSEMA 235 Score = 75.5 bits (184), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 54/218 (24%), Positives = 102/218 (46%), Gaps = 16/218 (7%) Query: 138 ELAGHTGY---LSCCRFLDD-NQIVTSSGDTTCALWDIETGQQTTT---------FTGHT 184 +L GH G+ L+C + + ++V++S D T W + ++ GH+ Sbjct: 8 QLTGHRGWVTSLACPQTPETATKVVSTSRDKTLLSWGPNPDRHSSECSYGLPDRRLEGHS 67 Query: 185 GDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATG 244 V ++L+ + VS + D S +LW+++ G C+ F GH D+ ++ F P+ +G Sbjct: 68 AFVSDVALSNNGNFAVSASWDHSLRLWNLQNGQCQYKFLGHTKDVLSVAFSPDNRQIVSG 127 Query: 245 SDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKS--GRLLLAGYDDFNCNVWDALKA 302 D R+++++ + + T S ++ V FS S ++++G D VWD Sbjct: 128 GRDNALRVWNVKGEC-MHTLSRGAHTDWVSCVRFSPSLDAPVIVSGGWDNLVKVWDLATG 186 Query: 303 DRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 L GH N V+ + V+ DG A+ D ++W+ Sbjct: 187 RLVTDLKGHTNYVTSVTVSPDGSLCASSDKDGVARLWD 224 Score = 29.3 bits (64), Expect = 2.7, Method: Compositional matrix adjust. Identities = 31/157 (19%), Positives = 63/157 (40%), Gaps = 12/157 (7%) Query: 66 DSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYN 125 D+ ++VS D + +WD T V + +++V + +P G+ A D + +++ Sbjct: 165 DAPVIVSGGWDNLVKVWDLATGRLVTDLKGHTNYVTSVTVSPDGSLCASSDKDGVARLWD 224 Query: 126 LKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTG-HT 184 L E E+A C F + + ++ + ++D+E H Sbjct: 225 LTKGEA----LSEMAAGAPINQIC-FSPNRYWMCAATEKGIRIFDLENKDIIVELAPEHQ 279 Query: 185 G------DVMSLSLAPDTRLFVSGACDASAKLWDVRE 215 G + +S++ + D SG D ++W V E Sbjct: 280 GSKKIVPECVSIAWSADGSTLYSGYTDNVIRVWGVSE 316 >5OPT-p nrPDB Length = 318 Score = 99.8 bits (247), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 75/260 (28%), Positives = 114/260 (43%), Gaps = 17/260 (6%) Query: 48 RRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAP 107 R L GH A + + + VSAS D L +W+ T H + V++ ++P Sbjct: 60 ERRLEGHSAFVSDVALSNNGDFAVSASWDHSLRLWNLQTGVCQHKFLGHTKDVLSVTFSP 119 Query: 108 SGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRF---LDDNQIVTSSGDT 164 + GG DN ++N+K G + HT ++SC RF L+ IV+ D Sbjct: 120 DNRQIVSGGRDNALRVWNVK---GECLHTLGRGAHTDWVSCVRFSPSLETPLIVSGGWDN 176 Query: 165 TCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTG 224 +WDI +G+ T GHT + S++++PD L S D A+LWD+ +G Sbjct: 177 LVKVWDIASGRLLTDLKGHTNYITSVTVSPDGSLCASSDKDGVARLWDLTKGEALSEMAA 236 Query: 225 HESDINAICFFPNGNAFATGSDDATCRLFDLRAD-------QELMTYSHDNIICGITSVS 277 + IN ICF PN + + + R+FDL E S C S++ Sbjct: 237 G-APINQICFSPN-RYWMCAATEKGIRIFDLENKDVIVELAPEAQQKSKKTPEC--MSIA 292 Query: 278 FSKSGRLLLAGYDDFNCNVW 297 +S G L +GY D VW Sbjct: 293 WSADGNTLYSGYTDNVIRVW 312 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 56/218 (25%), Positives = 101/218 (46%), Gaps = 16/218 (7%) Query: 138 ELAGHTGYLSC--CRFLDDNQI--VTSSGDTTCALW---------DIETGQQTTTFTGHT 184 +L GH G+++ C + + I V++S D T W + E G GH+ Sbjct: 8 QLKGHRGWVTALACPQITETYIKAVSTSRDNTLIAWGSNMDRNSEECEYGFPERRLEGHS 67 Query: 185 GDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATG 244 V ++L+ + VS + D S +LW+++ G+C+ F GH D+ ++ F P+ +G Sbjct: 68 AFVSDVALSNNGDFAVSASWDHSLRLWNLQTGVCQHKFLGHTKDVLSVTFSPDNRQIVSG 127 Query: 245 SDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKS--GRLLLAGYDDFNCNVWDALKA 302 D R+++++ + L T ++ V FS S L+++G D VWD Sbjct: 128 GRDNALRVWNVKGEC-LHTLGRGAHTDWVSCVRFSPSLETPLIVSGGWDNLVKVWDIASG 186 Query: 303 DRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 L GH N ++ + V+ DG A+ D ++W+ Sbjct: 187 RLLTDLKGHTNYITSVTVSPDGSLCASSDKDGVARLWD 224 Score = 71.2 bits (173), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 54/180 (30%), Positives = 89/180 (49%), Gaps = 12/180 (6%) Query: 137 RELAGHTGYLSCCRFLDDNQI-VTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPD 195 R L GH+ ++S ++ V++S D + LW+++TG F GHT DV+S++ +PD Sbjct: 61 RRLEGHSAFVSDVALSNNGDFAVSASWDHSLRLWNLQTGVCQHKFLGHTKDVLSVTFSPD 120 Query: 196 TRLFVSGACDASAKLWDVREGMCRQTFT--GHESDINAICFFPNGNA--FATGSDDATCR 251 R VSG D + ++W+V+ G C T H ++ + F P+ +G D + Sbjct: 121 NRQIVSGGRDNALRVWNVK-GECLHTLGRGAHTDWVSCVRFSPSLETPLIVSGGWDNLVK 179 Query: 252 LFDLRADQELMT--YSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLA 309 ++D+ A L+T H N I TSV+ S G L + D +WD K + +A Sbjct: 180 VWDI-ASGRLLTDLKGHTNYI---TSVTVSPDGSLCASSDKDGVARLWDLTKGEALSEMA 235 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 42/215 (19%), Positives = 78/215 (36%), Gaps = 57/215 (26%) Query: 53 GHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIP--LRSSWVMTCAYAPS-- 108 GH + ++ + D+R +VS +D L +W+ +H + + WV ++PS Sbjct: 107 GHTKDVLSVTFSPDNRQIVSGGRDNALRVWN-VKGECLHTLGRGAHTDWVSCVRFSPSLE 165 Query: 109 GNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSS-GDTTCA 167 + GG DN+ ++++ + R+ +L GHT Y++ D + SS D Sbjct: 166 TPLIVSGGWDNLVKVWDIASG----RLLTDLKGHTNYITSVTVSPDGSLCASSDKDGVAR 221 Query: 168 LWDIETGQQTTTF----------------------------------------------- 180 LWD+ G+ + Sbjct: 222 LWDLTKGEALSEMAAGAPINQICFSPNRYWMCAATEKGIRIFDLENKDVIVELAPEAQQK 281 Query: 181 TGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVRE 215 + T + MS++ + D SG D ++W V E Sbjct: 282 SKKTPECMSIAWSADGNTLYSGYTDNVIRVWSVSE 316 >6G51-g nrPDB Length = 317 Score = 99.4 bits (246), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 74/267 (27%), Positives = 123/267 (46%), Gaps = 15/267 (5%) Query: 48 RRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAP 107 +R LRGH + + +D + +S S DG L +WD T + V++ A++ Sbjct: 56 QRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSS 115 Query: 108 SGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDD--NQIVTSSG-DT 164 + G D ++N G + + + H+ ++SC RF + N I+ S G D Sbjct: 116 DNRQIVSGSRDKTIKLWN---TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDK 172 Query: 165 TCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTG 224 +W++ + T GHTG + +++++PD L SG D A LWD+ EG T G Sbjct: 173 LVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG 232 Query: 225 HESDINAICFFPNGNAFATGSDDATCRLFDLRA-------DQELMTYSHDNIICGITSVS 277 + INA+CF PN + + + +++DL QE+++ S TS++ Sbjct: 233 GDI-INALCFSPN-RYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLA 290 Query: 278 FSKSGRLLLAGYDDFNCNVWDALKADR 304 +S G+ L AGY D VW R Sbjct: 291 WSADGQTLFAGYTDNLVRVWQVTIGTR 317 Score = 76.6 bits (187), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 72/250 (28%), Positives = 111/250 (44%), Gaps = 14/250 (5%) Query: 99 WVMTCAYAPS-GNYVACGGLDNICSIYNLKTREGNVRVS-RELAGHTGYLSCCRFLDDNQ 156 WV A P + + D ++ L E N + R L GH+ ++S D Q Sbjct: 17 WVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQ 76 Query: 157 IVTS-SGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVRE 215 S S D T LWD+ TG T F GHT DV+S++ + D R VSG+ D + KLW+ Sbjct: 77 FALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTL- 135 Query: 216 GMCRQTF--TGHESDINAICFFPNGN--AFATGSDDATCRLFDLRADQELMTYSHDNIIC 271 G+C+ T H ++ + F PN + + D ++++L A+ +L T +H Sbjct: 136 GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNL-ANCKLKT-NHIGHTG 193 Query: 272 GITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHD-NRVSCLGVTDDGMAVATG 330 + +V+ S G L +G D +WD + L G D C + ATG Sbjct: 194 YLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATG 253 Query: 331 SWDSFLKIWN 340 +KIW+ Sbjct: 254 ---PSIKIWD 260 >1VYH-C nrPDB Length = 410 Score = 98.6 bits (244), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 83/358 (23%), Positives = 153/358 (42%), Gaps = 32/358 (8%) Query: 6 QLRQEAEQLKNQIRDARKA-CADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWG 64 +L+++ +L++++ +A++ + L Q + + + R + L GH + + + + Sbjct: 60 RLQKKVMELESKLNEAKEEFTSGGPLGQKRDPKEWIPRPP--EKYALSGHRSPVTRVIFH 117 Query: 65 TDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIY 124 ++VSAS+D + +WD T + + + V ++ SG +A D ++ Sbjct: 118 PVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLW 177 Query: 125 NLKTREGNVRVSRELAGHTGYLSCCRFLDD-NQIVTSSGDTTCALWDIETGQQTTTFTGH 183 + + E R + GH +S + + + IV++S D T +W+++TG TFTGH Sbjct: 178 DFQGFE----CIRTMHGHDHNVSSVSIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGH 233 Query: 184 TGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPN------ 237 V + D L S + D + ++W V C+ H + I + P Sbjct: 234 REWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHRHVVECISWAPESSYSSI 293 Query: 238 --------------GNAFATGSDDATCRLFDLRADQELMTY-SHDNIICGITSVSFSKSG 282 G +GS D T +++D+ LMT HDN + G+ F G Sbjct: 294 SEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVL---FHSGG 350 Query: 283 RLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 + +L+ DD VWD L H++ V+ L V TGS D +K+W Sbjct: 351 KFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408 Score = 67.4 bits (163), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 50/229 (21%), Positives = 89/229 (38%), Gaps = 25/229 (10%) Query: 49 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPS 108 RT+ GH + ++ + +VSAS+D + +W+ T V WV Sbjct: 186 RTMHGHDHNVSSVSIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQD 245 Query: 109 GNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQ------------ 156 G +A D ++ + T+E EL H + C + ++ Sbjct: 246 GTLIASCSNDQTVRVWVVATKECKA----ELREHRHVVECISWAPESSYSSISEATGSET 301 Query: 157 ---------IVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDAS 207 +++ S D T +WD+ TG T GH V + + +S A D + Sbjct: 302 KKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKT 361 Query: 208 AKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLR 256 ++WD + C +T HE + ++ F TGS D T ++++ R Sbjct: 362 LRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410 >6QX9-5O nrPDB Length = 357 Score = 93.6 bits (231), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 72/252 (28%), Positives = 118/252 (46%), Gaps = 18/252 (7%) Query: 100 VMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRF-LDDNQIV 158 V C + P+G+ +A G D + ++N+ G+ L GH+G + + D + + Sbjct: 69 VYCCKFHPNGSTLASAGFDRLILLWNVY---GDCDNYATLKGHSGAVMELHYNTDGSMLF 125 Query: 159 TSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAP-DTRLFVSGACDASAKLWDVREGM 217 ++S D T A+WD ETG++ GHT V S A +L +G+ D + KLWD+R+ Sbjct: 126 SASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKA 185 Query: 218 CRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVS 277 QTF + + A+ F + +G D +++DLR Q +TY+ +T +S Sbjct: 186 AIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLR--QNKLTYTMRGHADSVTGLS 242 Query: 278 FSKSGRLLLAGYDDFNCNVWDA---------LKADRAGVLAGHDNRVSCLGVTDDGMAVA 328 S G LL+ D VWD +K + V N + C + DG +A Sbjct: 243 LSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRC-SWSPDGSKIA 301 Query: 329 TGSWDSFLKIWN 340 GS D F+ +W+ Sbjct: 302 AGSADRFVYVWD 313 Score = 89.4 bits (220), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 54/205 (26%), Positives = 99/205 (48%), Gaps = 6/205 (2%) Query: 139 LAGHTGYLSCCRFLDDNQIVTSSG-DTTCALWDIETG-QQTTTFTGHTGDVMSLSLAPDT 196 L+GH G + CC+F + + S+G D LW++ T GH+G VM L D Sbjct: 62 LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDG 121 Query: 197 RLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFA-TGSDDATCRLFDL 255 + S + D + +WD G + GH S +N+ G TGSDD T +L+D+ Sbjct: 122 SMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDI 181 Query: 256 RADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRV 315 R + T+ + + +T F+ + +++G D + VWD + + GH + V Sbjct: 182 RKKAAIQTFQNTYQVLAVT---FNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSV 238 Query: 316 SCLGVTDDGMAVATGSWDSFLKIWN 340 + L ++ +G + + + D+ +++W+ Sbjct: 239 TGLSLSSEGSYLLSNAMDNTVRVWD 263 Score = 88.2 bits (217), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 65/252 (25%), Positives = 118/252 (46%), Gaps = 17/252 (6%) Query: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109 TL+GH + +H+ TD +L SAS D + +WDS T +V + +S+V +C A G Sbjct: 104 TLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRG 163 Query: 110 NYVACGGLDN-ICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLD-DNQIVTSSGDTTCA 167 + C G D+ +++++ + + + +T + F D +QI++ D Sbjct: 164 PQLVCTGSDDGTVKLWDIRK-----KAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIK 218 Query: 168 LWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVR----EGMCRQTFT 223 +WD+ + T T GH V LSL+ + +S A D + ++WDVR + C + F Sbjct: 219 VWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQ 278 Query: 224 GH----ESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFS 279 G+ E ++ + P+G+ A GS D ++D + + L Y I V+F Sbjct: 279 GNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRIL--YKLPGHAGSINEVAFH 336 Query: 280 KSGRLLLAGYDD 291 ++++ D Sbjct: 337 PDEPIIISASSD 348 Score = 84.7 bits (208), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 80/300 (26%), Positives = 127/300 (42%), Gaps = 24/300 (8%) Query: 51 LRGHLAKIYAMHWGTDSRLLVSASQDGKLIIW------DSYTTNKVHAIPLRSSWVMTCA 104 L GH ++Y + + L SA D +++W D+Y T K H S VM Sbjct: 62 LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGH-----SGAVMELH 116 Query: 105 YAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYL-SCCRFLDDNQIV-TSSG 162 Y G+ + D ++++ +T E RV R L GHT ++ SC Q+V T S Sbjct: 117 YNTDGSMLFSASTDKTVAVWDSETGE---RVKR-LKGHTSFVNSCYPARRGPQLVCTGSD 172 Query: 163 DTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTF 222 D T LWDI TF +T V++++ + +SG D K+WD+R+ T Sbjct: 173 DGTVKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTM 231 Query: 223 TGHESDINAICFFPNGNAFATGSDDATCRLFDLR--ADQE----LMTYSHDNIICGITSV 276 GH + + G+ + + D T R++D+R A +E + + N + Sbjct: 232 RGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRC 291 Query: 277 SFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFL 336 S+S G + AG D VWD L GH ++ + D + + S D L Sbjct: 292 SWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRL 351 Score = 45.8 bits (107), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 28/163 (17%), Positives = 66/163 (40%), Gaps = 5/163 (3%) Query: 57 KIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGG 116 ++ A+ + S ++S D + +WD + + + V + + G+Y+ Sbjct: 195 QVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNA 254 Query: 117 LDNICSIYNLKTREGNVRVSRELAGHT-----GYLSCCRFLDDNQIVTSSGDTTCALWDI 171 +DN +++++ R + G+ L C D ++I S D +WD Sbjct: 255 MDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDT 314 Query: 172 ETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVR 214 + + GH G + ++ PD + +S + D + +++ Sbjct: 315 TSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYMGEIQ 357 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 34/152 (22%), Positives = 64/152 (42%), Gaps = 19/152 (12%) Query: 33 ITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWD--------- 83 I N+I Q + T+RGH + + ++ L+S + D + +WD Sbjct: 213 IDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKER 272 Query: 84 --SYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAG 141 VH ++ C+++P G+ +A G D +++ +R R+ +L G Sbjct: 273 CVKIFQGNVHNF---EKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSR----RILYKLPG 325 Query: 142 HTGYLSCCRFLDDNQIVTS-SGDTTCALWDIE 172 H G ++ F D I+ S S D + +I+ Sbjct: 326 HAGSINEVAFHPDEPIIISASSDKRLYMGEIQ 357 Score = 28.5 bits (62), Expect = 4.6, Method: Compositional matrix adjust. Identities = 10/34 (29%), Positives = 19/34 (55%) Query: 307 VLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 +L+GH+ V C +G +A+ +D + +WN Sbjct: 61 LLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWN 94 >5Z56-q nrPDB Length = 504 Score = 91.7 bits (226), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 54/214 (25%), Positives = 90/214 (42%), Gaps = 11/214 (5%) Query: 137 RELAGHTGY----------LSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGD 186 R++A H G L C D N+I+T D ++D + Q T GHT Sbjct: 208 RQVASHVGLHSASIPGILALDLCPS-DTNKILTGGADKNVVVFDKSSEQILATLKGHTKK 266 Query: 187 VMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSD 246 V S+ P L S + DA+ ++W V C Q HES + + G+ + SD Sbjct: 267 VTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSD 326 Query: 247 DATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAG 306 D D++ + L + + C +T F G + G D +WD + Sbjct: 327 DQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVA 386 Query: 307 VLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 GH ++ + +++G +AT + DS +K+W+ Sbjct: 387 NFPGHSGPITSIAFSENGYYLATAADDSSVKLWD 420 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 61/238 (25%), Positives = 106/238 (44%), Gaps = 9/238 (3%) Query: 65 TDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIY 124 +D+ +++ D ++++D + + + + V + + PS + V D I+ Sbjct: 232 SDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIW 291 Query: 125 NLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHT 184 ++ V+V R A + + +++SS D A DI+TG+ T T T Sbjct: 292 SVP-NASCVQVVR--AHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDET 348 Query: 185 G--DVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFA 242 + PD +F +G D+ K+WD++E F GH I +I F NG A Sbjct: 349 SGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLA 408 Query: 243 TGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDD---FNCNVW 297 T +DD++ +L+DLR + T DN + S+ F +SG L G D + C W Sbjct: 409 TAADDSSVKLWDLRKLKNFKTLQLDNNF-EVKSLIFDQSGTYLALGGTDVQIYICKQW 465 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 53/227 (23%), Positives = 108/227 (47%), Gaps = 7/227 (3%) Query: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109 TL+GH K+ ++ + L+ SAS D + IW + V + S V + +G Sbjct: 259 TLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATG 318 Query: 110 NYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIV-TSSGDTTCAL 168 +Y+ D + +++T +V+ E +G + L+C +F D I T + D+ + Sbjct: 319 DYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCS--LTCAQFHPDGLIFGTGTMDSQIKI 376 Query: 169 WDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFT-GHES 227 WD++ F GH+G + S++ + + + A D+S KLWD+R+ +T + Sbjct: 377 WDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNF 436 Query: 228 DINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYS-HDNIICGI 273 ++ ++ F +G A G D +++ + E++ ++ H + G+ Sbjct: 437 EVKSLIFDQSGTYLALGGTD--VQIYICKQWTEILHFTEHSGLTTGV 481 >3JAP-g nrPDB Length = 326 Score = 91.3 bits (225), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 85/323 (26%), Positives = 131/323 (40%), Gaps = 34/323 (10%) Query: 43 IQMRTRRTLRGHLAKIYAMHW-GTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRS---- 97 I + R TL GH + ++ LLVS S+D LI W + +P+RS Sbjct: 6 IMLVLRGTLEGHNGWVTSLSTSAAQPNLLVSGSRDKTLISWRLTENEQQFGVPVRSYKGH 65 Query: 98 -SWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTG-YLSCCRFLDDN 155 V + GNY D ++NL T R GHTG LS + + Sbjct: 66 SHIVQDVVVSADGNYAVSASWDKTLRLWNLATGNSEAR----FVGHTGDVLSVAIDANSS 121 Query: 156 QIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAP---------DTRL-FVSGACD 205 +I+++S D T +W+ G GHT V + +AP D R+ FVS D Sbjct: 122 KIISASRDKTIRVWNT-VGDCAYVLLGHTDWVTKVRVAPKNLEDGEVDDGRITFVSAGMD 180 Query: 206 ASAKLWDVREGMCR--QTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMT 263 + W + E R F GH + IN + P+G+ A+ D +++L+ M Sbjct: 181 KIVRSWSLNEDSYRIEADFIGHNNYINVVQPSPDGSLAASAGKDGQIYVWNLKHKSAFMN 240 Query: 264 YSHDNIICGITSVSFSKSGRLLLAG-------YDDFNCNVWDALKADRAGVLAGHDNRVS 316 + + + + +FS S L A YD N + D LK + AG D Sbjct: 241 FDAKDEVFAL---AFSPSRFWLTAATASGIKIYDLENEVLIDELKPEFAGYTKAQDPHAV 297 Query: 317 CLGVTDDGMAVATGSWDSFLKIW 339 L + DG + G D+ +++W Sbjct: 298 SLAWSADGQTLFAGYTDNVIRVW 320 Score = 58.9 bits (141), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 50/220 (22%), Positives = 92/220 (41%), Gaps = 20/220 (9%) Query: 139 LAGHTGYLSCCR--FLDDNQIVTSSGDTTCALWDIETGQQ-----TTTFTGHTGDVMSLS 191 L GH G+++ N +V+ S D T W + +Q ++ GH+ V + Sbjct: 14 LEGHNGWVTSLSTSAAQPNLLVSGSRDKTLISWRLTENEQQFGVPVRSYKGHSHIVQDVV 73 Query: 192 LAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCR 251 ++ D VS + D + +LW++ G F GH D+ ++ N + + S D T R Sbjct: 74 VSADGNYAVSASWDKTLRLWNLATGNSEARFVGHTGDVLSVAIDANSSKIISASRDKTIR 133 Query: 252 LFDLRADQELMTYSHDNIICGITSVSFS------KSGRLLL--AGYDDFNCNVWDALKAD 303 +++ D + H + + + + GR+ AG D W +L D Sbjct: 134 VWNTVGDCAYVLLGHTDWVTKVRVAPKNLEDGEVDDGRITFVSAGMDKI-VRSW-SLNED 191 Query: 304 RAGVLA---GHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 + A GH+N ++ + + DG A+ D + +WN Sbjct: 192 SYRIEADFIGHNNYINVVQPSPDGSLAASAGKDGQIYVWN 231 Score = 31.6 bits (70), Expect = 0.48, Method: Compositional matrix adjust. Identities = 36/168 (21%), Positives = 58/168 (34%), Gaps = 50/168 (29%) Query: 179 TFTGHTGDVMSLSL-APDTRLFVSGACDASAKLWDVRE-----GMCRQTFTGHESDINAI 232 T GH G V SLS A L VSG+ D + W + E G+ +++ GH + + Sbjct: 13 TLEGHNGWVTSLSTSAAQPNLLVSGSRDKTLISWRLTENEQQFGVPVRSYKGHSHIVQDV 72 Query: 233 CFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDF 292 +GN + S D T RL+ N+ G + F Sbjct: 73 VVSADGNYAVSASWDKTLRLW--------------NLATGNSEARF-------------- 104 Query: 293 NCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 GH V + + + + + S D +++WN Sbjct: 105 ----------------VGHTGDVLSVAIDANSSKIISASRDKTIRVWN 136 >6EOJ-D nrPDB Length = 470 Score = 90.9 bits (224), Expect = 7e-19, Method: Compositional matrix adjust. Identities = 76/289 (26%), Positives = 125/289 (43%), Gaps = 14/289 (4%) Query: 58 IYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGL 117 I A+ W + R LV A+ G+ +W++ + + S V T Y+ +++ G Sbjct: 96 IPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDA 155 Query: 118 DNICSIYNLKTREGNVRVSREL-AGHTGYLSCCRFL-DDNQIVTSSGDTTCALWDIETGQ 175 D + I+ + N + +E+ A HT + F +D++ VT S D +W+ G+ Sbjct: 156 DGMIKIW-----QPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGK 210 Query: 176 QTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFF 235 Q +GH DV S P+ L S + D KLWD R G C + + + F Sbjct: 211 QERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQ 270 Query: 236 P-NGNAFATGSDDATCRLFDLRAD-QELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFN 293 P GN S D +CR+FD+R +ELM + + ++S LA YD + Sbjct: 271 PTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINES-MFTLACYDG-S 328 Query: 294 CNVWDALKADRAGVLA---GHDNRVSCLGVTDDGMAVATGSWDSFLKIW 339 +D L+ +L HD ++ L G AT + D ++ W Sbjct: 329 LKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFW 377 Score = 61.6 bits (148), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 59/255 (23%), Positives = 108/255 (42%), Gaps = 16/255 (6%) Query: 51 LRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPS-G 109 ++ H + + M + DS ++S DG + IW + + + A++ + Sbjct: 131 MQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDS 190 Query: 110 NYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTS-SGDTTCAL 168 +V C DNI I+N N + R L+GH + C + + ++ S S D L Sbjct: 191 KFVTCSD-DNILKIWNF----SNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKL 245 Query: 169 WDIETGQQTTTFTGHTGDVMSLSLAPDT-RLFVSGACDASAKLWDVREGMCRQTFTGHES 227 WD +G ++ V+ P L ++ + D S +++D+R M E+ Sbjct: 246 WDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDET 305 Query: 228 DINAICFFP-NGNAFATGSDDATCRLFDL--RADQELMT--YSHDNIICGITSVSFSKSG 282 D + + P N + F D + + FDL ++ ++T Y+HD C ITS+S++ G Sbjct: 306 DYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDK--C-ITSLSYNPVG 362 Query: 283 RLLLAGYDDFNCNVW 297 + D W Sbjct: 363 HIFATAAKDRTIRFW 377 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 48/213 (22%), Positives = 81/213 (38%), Gaps = 50/213 (23%) Query: 46 RTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAY 105 + R L GH + + W + L+ SAS+D + +WD + N + +I V+ + Sbjct: 210 KQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRF 269 Query: 106 APS-GNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDT 164 P+ GN + D C ++ ++R S + L C R D Sbjct: 270 QPTKGNLLMAISKDKSCRVF-------DIRYSMK------ELMCVR------------DE 304 Query: 165 TCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGAC-DASAKLWDVREGMCRQTFT 223 T D M+L P + AC D S K +D+ + + T Sbjct: 305 T--------------------DYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILT 344 Query: 224 ---GHESDINAICFFPNGNAFATGSDDATCRLF 253 H+ I ++ + P G+ FAT + D T R + Sbjct: 345 IPYAHDKCITSLSYNPVGHIFATAAKDRTIRFW 377 Score = 29.6 bits (65), Expect = 2.0, Method: Compositional matrix adjust. Identities = 24/113 (21%), Positives = 47/113 (41%), Gaps = 4/113 (3%) Query: 229 INAICFFPNGNAFATGSDDATCRLFDLRADQ-ELMTYSHDNIICGITSVSFSKSGRLLLA 287 I AI + P G + L++ + E + +HD+ +T++ +S +++ Sbjct: 96 IPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDS---AVTTMKYSHDSDWMIS 152 Query: 288 GYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 G D +W + + A H + + + + T S D+ LKIWN Sbjct: 153 GDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWN 205 >6HQA-B nrPDB Length = 722 Score = 90.9 bits (224), Expect = 7e-19, Method: Compositional matrix adjust. Identities = 59/221 (26%), Positives = 106/221 (47%), Gaps = 7/221 (3%) Query: 124 YNLKTREG-NVRVSRELAGHTGYLSCCRFLDDNQ-IVTSSGDTTCALWDIETGQQTTTFT 181 YN + +G V+ SR L GH+G + F DN+ +++ S D T LW ++T ++ Sbjct: 433 YNQQNNDGVAVKGSRRLVGHSGAVYGVDFSPDNRYLISCSEDKTVRLWSLDTYTCLVSYK 492 Query: 182 GHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAF 241 GH+ V + +P F + + D +A+LW + F GH +D++ + F PN Sbjct: 493 GHSSSVWDVKFSPMGHYFATASHDQTARLWSCDHIYPLRIFAGHLNDVDCVEFHPNSTYL 552 Query: 242 ATGSDDATCRLFDL-RADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDAL 300 TGS D T R++D+ R + + H I ++ S GR L + +D +WD Sbjct: 553 FTGSSDKTARMWDIARGECVRVFMGHSG---AINCLAVSPDGRWLASAGEDSVVCLWDIS 609 Query: 301 KADRAGVLAGH-DNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 R + GH + + L + +G + + D+ +++W+ Sbjct: 610 TGRRIKAMRGHGRSSIYSLAFSREGTVLVSTGADNSVRVWD 650 Score = 89.7 bits (221), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 61/218 (27%), Positives = 97/218 (44%), Gaps = 26/218 (11%) Query: 146 LSCCRFLDDNQIVTSS-GDTTCALWDIE------------TGQQ---------TTTFTGH 183 L+C +F DD+ +V S D+ LW I+ QQ + GH Sbjct: 393 LTCLKFNDDSTMVASGFQDSFIKLWSIDGSPLRSLLKNDPYNQQNNDGVAVKGSRRLVGH 452 Query: 184 TGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFAT 243 +G V + +PD R +S + D + +LW + C ++ GH S + + F P G+ FAT Sbjct: 453 SGAVYGVDFSPDNRYLISCSEDKTVRLWSLDTYTCLVSYKGHSSSVWDVKFSPMGHYFAT 512 Query: 244 GSDDATCRLFDLRADQELMTYS-HDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKA 302 S D T RL+ L ++ H N + V F + L G D +WD + Sbjct: 513 ASHDQTARLWSCDHIYPLRIFAGHLN---DVDCVEFHPNSTYLFTGSSDKTARMWDIARG 569 Query: 303 DRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 + V GH ++CL V+ DG +A+ DS + +W+ Sbjct: 570 ECVRVFMGHSGAINCLAVSPDGRWLASAGEDSVVCLWD 607 Score = 33.9 bits (76), Expect = 0.11, Method: Compositional matrix adjust. Identities = 13/29 (44%), Positives = 20/29 (68%) Query: 312 DNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 +N ++CL DD VA+G DSF+K+W+ Sbjct: 390 NNDLTCLKFNDDSTMVASGFQDSFIKLWS 418 >4LG8-A nrPDB Length = 354 Score = 90.5 bits (223), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 54/214 (25%), Positives = 90/214 (42%), Gaps = 11/214 (5%) Query: 137 RELAGHTGY----------LSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGD 186 R++A H G L C D N+I+T D ++D + Q T GHT Sbjct: 58 RQVASHVGLHSASIPGILALDLCP-SDTNKILTGGADKNVVVFDKSSEQILATLKGHTKK 116 Query: 187 VMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSD 246 V S+ P L S + DA+ ++W V C Q HES + + G+ + SD Sbjct: 117 VTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSD 176 Query: 247 DATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAG 306 D D++ + L + + C +T F G + G D +WD + Sbjct: 177 DQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVA 236 Query: 307 VLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 GH ++ + +++G +AT + DS +K+W+ Sbjct: 237 NFPGHSGPITSIAFSENGYYLATAADDSSVKLWD 270 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 61/238 (25%), Positives = 106/238 (44%), Gaps = 9/238 (3%) Query: 65 TDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIY 124 +D+ +++ D ++++D + + + + V + + PS + V D I+ Sbjct: 82 SDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIW 141 Query: 125 NLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHT 184 ++ V+V R A + + +++SS D A DI+TG+ T T T Sbjct: 142 SVP-NASCVQVVR--AHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDET 198 Query: 185 G--DVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFA 242 + PD +F +G D+ K+WD++E F GH I +I F NG A Sbjct: 199 SGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLA 258 Query: 243 TGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDD---FNCNVW 297 T +DD++ +L+DLR + T DN + S+ F +SG L G D + C W Sbjct: 259 TAADDSSVKLWDLRKLKNFKTLQLDNNF-EVKSLIFDQSGTYLALGGTDVQIYICKQW 315 Score = 74.7 bits (182), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 53/227 (23%), Positives = 108/227 (47%), Gaps = 7/227 (3%) Query: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109 TL+GH K+ ++ + L+ SAS D + IW + V + S V + +G Sbjct: 109 TLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATG 168 Query: 110 NYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIV-TSSGDTTCAL 168 +Y+ D + +++T +V+ E +G + L+C +F D I T + D+ + Sbjct: 169 DYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCS--LTCAQFHPDGLIFGTGTMDSQIKI 226 Query: 169 WDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFT-GHES 227 WD++ F GH+G + S++ + + + A D+S KLWD+R+ +T + Sbjct: 227 WDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNF 286 Query: 228 DINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYS-HDNIICGI 273 ++ ++ F +G A G D +++ + E++ ++ H + G+ Sbjct: 287 EVKSLIFDQSGTYLALGGTD--VQIYICKQWTEILHFTEHSGLTTGV 331 >6GMH-W nrPDB Length = 305 Score = 90.1 bits (222), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 54/197 (27%), Positives = 102/197 (51%), Gaps = 5/197 (2%) Query: 59 YAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLD 118 + + + DS+ L + + GK+ I+ + K +++ R ++++ AY+P G Y+A G +D Sbjct: 110 WTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAID 169 Query: 119 NICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQI-VTSSGDTTCALWDIETGQQT 177 I +I+++ T ++ L GH + F D+Q+ VT+S D ++D++ Sbjct: 170 GIINIFDIATG----KLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLA 225 Query: 178 TTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPN 237 T +GH V++++ PD FVS + D S K+WDV C TF H+ + + + N Sbjct: 226 GTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGN 285 Query: 238 GNAFATGSDDATCRLFD 254 G+ + DD ++D Sbjct: 286 GSKIVSVGDDQEIHIYD 302 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 53/201 (26%), Positives = 91/201 (45%), Gaps = 5/201 (2%) Query: 112 VACGGLDNICSIYNLKTREGNVRVSRELAGHT-GYLSCCRFLDDNQIVTSSGDTTCALWD 170 V G LD++ ++ K R+ + + L GH G +S +SS D LWD Sbjct: 35 VVTGSLDDLVKVW--KWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWD 92 Query: 171 IETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDIN 230 +E G+Q + D +L+ +PD++ +G ++ V G + I Sbjct: 93 LENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFIL 152 Query: 231 AICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYD 290 +I + P+G A+G+ D +FD+ + L T + I S++FS +LL+ D Sbjct: 153 SIAYSPDGKYLASGAIDGIINIFDIATGKLLHTL--EGHAMPIRSLTFSPDSQLLVTASD 210 Query: 291 DFNCNVWDALKADRAGVLAGH 311 D ++D A+ AG L+GH Sbjct: 211 DGYIKIYDVQHANLAGTLSGH 231 Score = 70.9 bits (172), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 58/256 (22%), Positives = 120/256 (46%), Gaps = 7/256 (2%) Query: 44 QMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTC 103 ++ + +L GH + ++ + S+S D + +WD ++ +I T Sbjct: 53 RLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTL 112 Query: 104 AYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGD 163 A++P Y+A G +I+ +++ G S + G LS D + + + D Sbjct: 113 AFSPDSQYLATGTHVGKVNIFGVES--GKKEYSLDTRGKF-ILSIAYSPDGKYLASGAID 169 Query: 164 TTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFT 223 ++DI TG+ T GH + SL+ +PD++L V+ + D K++DV+ T + Sbjct: 170 GIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLS 229 Query: 224 GHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMT-YSHDNIICGITSVSFSKSG 282 GH S + + F P+ F + S D + +++D+ + T + H + + G V ++ +G Sbjct: 230 GHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWG---VKYNGNG 286 Query: 283 RLLLAGYDDFNCNVWD 298 +++ DD +++D Sbjct: 287 SKIVSVGDDQEIHIYD 302 >5I2T-A nrPDB Length = 742 Score = 87.4 bits (215), Expect = 7e-18, Method: Compositional matrix adjust. Identities = 50/165 (30%), Positives = 78/165 (47%), Gaps = 12/165 (7%) Query: 182 GHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAF 241 GH SL+ +PD V+ + D K+WD+ G C TF H S + A+ F G Sbjct: 368 GHFDSTNSLAYSPDGSRVVTASEDGKIKVWDITSGFCLATFEEHTSSVTAVQFAKRGQVM 427 Query: 242 ATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFS-----KSGRLLLAG-YDDFNCN 295 + S D T R +D L+ Y + G + F+ SG ++ AG D+F+ + Sbjct: 428 FSSSLDGTVRAWD------LIRYRNFRTFTGTERIQFNCLAVDPSGEVVCAGSLDNFDIH 481 Query: 296 VWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 VW L+GH+ VSCL + + +A+ SWD ++IW+ Sbjct: 482 VWSVQTGQLLDALSGHEGPVSCLSFSQENSVLASASWDKTIRIWS 526 Score = 62.0 bits (149), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 62/294 (21%), Positives = 115/294 (39%), Gaps = 55/294 (18%) Query: 52 RGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNY 111 +GH ++ + D +V+AS+DGK+ +WD + + +S V +A G Sbjct: 367 QGHFDSTNSLAYSPDGSRVVTASEDGKIKVWDITSGFCLATFEEHTSSVTAVQFAKRGQV 426 Query: 112 VACGGLD------NICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTT 165 + LD ++ N +T G R+ +C V SG+ Sbjct: 427 MFSSSLDGTVRAWDLIRYRNFRTFTGTERIQ---------FNCL-------AVDPSGEVV 470 Query: 166 CA---------LWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREG 216 CA +W ++TGQ +GH G V LS + + + S + D + ++W + Sbjct: 471 CAGSLDNFDIHVWSVQTGQLLDALSGHEGPVSCLSFSQENSVLASASWDKTIRIWSIFGR 530 Query: 217 MCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSV 276 + SD+ A+ P+G A + +F++ +++ NI C + Sbjct: 531 SQQVEPIEVYSDVLALSMRPDGKEVAVSTLKGQISIFNIEDAKQV-----GNIDCRKDII 585 Query: 277 SFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATG 330 SGR FN + + A ++R+ + + + DGMA+ G Sbjct: 586 ----SGR--------FNQDRFTAKNSERSKFF-------TTIHYSFDGMAIVAG 620 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 40/151 (26%), Positives = 67/151 (44%), Gaps = 7/151 (4%) Query: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTC-AYAPS 108 T H + + A+ + +++ S+S DG + WD C A PS Sbjct: 407 TFEEHTSSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVDPS 466 Query: 109 GNYVACGGLDNI-CSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSG-DTTC 166 G V G LDN +++++T + + L+GH G +SC F +N ++ S+ D T Sbjct: 467 GEVVCAGSLDNFDIHVWSVQTGQ----LLDALSGHEGPVSCLSFSQENSVLASASWDKTI 522 Query: 167 ALWDIETGQQTTTFTGHTGDVMSLSLAPDTR 197 +W I Q DV++LS+ PD + Sbjct: 523 RIWSIFGRSQQVEPIEVYSDVLALSMRPDGK 553 Score = 54.3 bits (129), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 72/347 (20%), Positives = 132/347 (38%), Gaps = 39/347 (11%) Query: 30 LSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNK 89 LS + N + I ++ H I A+ LL+S +DG+ I+ + N Sbjct: 55 LSPVGNRVSVFDLINNKSFTFEYEHRKNIAAIDLNKQGTLLISIDEDGRAILVNFKARNV 114 Query: 90 VHAIPLRSSWVMTCAYAPSGNY--VACGGLDNICSIYNL-KTREGNVRVSREL-AGHTGY 145 +H + ++P G +A G I ++ K R+ V + AGH Sbjct: 115 LHHFNFKEK-CSAVKFSPDGRLFALASGRFLQIWKTPDVNKDRQFAPFVRHRVHAGHFQD 173 Query: 146 LSCCRFLDDNQ-IVTSSGDTTCALWDIETGQQT---TTFTGHTGDVMSLSLAPDTRLFVS 201 ++ + D++ I+T+S D + +W +++ ++ TTF GH VM + D + Sbjct: 174 ITSLTWSQDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGAFFSHDQEKIYT 233 Query: 202 GACDASAKLW-----------------------DVREGMCRQT----FTGHESDINAICF 234 + D + +W D+ + R T F +++ + + F Sbjct: 234 VSKDGAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQAKVKCVTF 293 Query: 235 FPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDF-N 293 P A G RL+DL + S + +VS +++G L G Sbjct: 294 HPATRLLAVGFTSGEFRLYDLPDFTLIQQLSMGQ--NPVNTVSVNQTGEWLAFGSSKLGQ 351 Query: 294 CNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 V++ GH + + L + DG V T S D +K+W+ Sbjct: 352 LLVYEWQSESYILKQQGHFDSTNSLAYSPDGSRVVTASEDGKIKVWD 398 Score = 41.2 bits (95), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 61/308 (19%), Positives = 113/308 (36%), Gaps = 53/308 (17%) Query: 71 VSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTRE 130 ++ S DGK ++ S N+V L ++ T Y N +A L+ ++ + Sbjct: 45 ITFSDDGKQLL--SPVGNRVSVFDLINNKSFTFEYEHRKN-IAAIDLNKQGTLLISIDED 101 Query: 131 GNVRV----SRELAGHTGYLSCC---RFLDDNQIVTSSGDTTCALW---DIETGQQTTTF 180 G + +R + H + C +F D ++ + +W D+ +Q F Sbjct: 102 GRAILVNFKARNVLHHFNFKEKCSAVKFSPDGRLFALASGRFLQIWKTPDVNKDRQFAPF 161 Query: 181 T------GHTGDVMSLSLAPDTRLFVSGACDASAKLWDV---REGMCRQTFTGHESDINA 231 GH D+ SL+ + D+R ++ + D SAK+W V + + TF GH + Sbjct: 162 VRHRVHAGHFQDITSLTWSQDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMG 221 Query: 232 ICFFPNGNAFATGSDDATCRLFDL----------------------------RADQELMT 263 F + T S D +++ R ++ Sbjct: 222 AFFSHDQEKIYTVSKDGAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFF 281 Query: 264 YSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDD 323 Y++ + V+F + RLL G+ ++D L+ N V+ + V Sbjct: 282 YANQ---AKVKCVTFHPATRLLAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTVSVNQT 338 Query: 324 GMAVATGS 331 G +A GS Sbjct: 339 GEWLAFGS 346 >5WLC-LO nrPDB Length = 923 Score = 87.4 bits (215), Expect = 7e-18, Method: Compositional matrix adjust. Identities = 50/165 (30%), Positives = 78/165 (47%), Gaps = 12/165 (7%) Query: 182 GHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAF 241 GH SL+ +PD V+ + D K+WD+ G C TF H S + A+ F G Sbjct: 343 GHFDSTNSLAYSPDGSRVVTASEDGKIKVWDITSGFCLATFEEHTSSVTAVQFAKRGQVM 402 Query: 242 ATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFS-----KSGRLLLAG-YDDFNCN 295 + S D T R +D L+ Y + G + F+ SG ++ AG D+F+ + Sbjct: 403 FSSSLDGTVRAWD------LIRYRNFRTFTGTERIQFNCLAVDPSGEVVCAGSLDNFDIH 456 Query: 296 VWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 VW L+GH+ VSCL + + +A+ SWD ++IW+ Sbjct: 457 VWSVQTGQLLDALSGHEGPVSCLSFSQENSVLASASWDKTIRIWS 501 Score = 62.0 bits (149), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 62/294 (21%), Positives = 115/294 (39%), Gaps = 55/294 (18%) Query: 52 RGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNY 111 +GH ++ + D +V+AS+DGK+ +WD + + +S V +A G Sbjct: 342 QGHFDSTNSLAYSPDGSRVVTASEDGKIKVWDITSGFCLATFEEHTSSVTAVQFAKRGQV 401 Query: 112 VACGGLD------NICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTT 165 + LD ++ N +T G R+ +C V SG+ Sbjct: 402 MFSSSLDGTVRAWDLIRYRNFRTFTGTERIQ---------FNCL-------AVDPSGEVV 445 Query: 166 CA---------LWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREG 216 CA +W ++TGQ +GH G V LS + + + S + D + ++W + Sbjct: 446 CAGSLDNFDIHVWSVQTGQLLDALSGHEGPVSCLSFSQENSVLASASWDKTIRIWSIFGR 505 Query: 217 MCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSV 276 + SD+ A+ P+G A + +F++ +++ NI C + Sbjct: 506 SQQVEPIEVYSDVLALSMRPDGKEVAVSTLKGQISIFNIEDAKQV-----GNIDCRKDII 560 Query: 277 SFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATG 330 SGR FN + + A ++R+ + + + DGMA+ G Sbjct: 561 ----SGR--------FNQDRFTAKNSERSKFF-------TTIHYSFDGMAIVAG 595 Score = 56.6 bits (135), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 40/151 (26%), Positives = 67/151 (44%), Gaps = 7/151 (4%) Query: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTC-AYAPS 108 T H + + A+ + +++ S+S DG + WD C A PS Sbjct: 382 TFEEHTSSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVDPS 441 Query: 109 GNYVACGGLDNI-CSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSG-DTTC 166 G V G LDN +++++T + + L+GH G +SC F +N ++ S+ D T Sbjct: 442 GEVVCAGSLDNFDIHVWSVQTGQ----LLDALSGHEGPVSCLSFSQENSVLASASWDKTI 497 Query: 167 ALWDIETGQQTTTFTGHTGDVMSLSLAPDTR 197 +W I Q DV++LS+ PD + Sbjct: 498 RIWSIFGRSQQVEPIEVYSDVLALSMRPDGK 528 Score = 54.3 bits (129), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 72/347 (20%), Positives = 132/347 (38%), Gaps = 39/347 (11%) Query: 30 LSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNK 89 LS + N + I ++ H I A+ LL+S +DG+ I+ + N Sbjct: 30 LSPVGNRVSVFDLINNKSFTFEYEHRKNIAAIDLNKQGTLLISIDEDGRAILVNFKARNV 89 Query: 90 VHAIPLRSSWVMTCAYAPSGNY--VACGGLDNICSIYNL-KTREGNVRVSREL-AGHTGY 145 +H + ++P G +A G I ++ K R+ V + AGH Sbjct: 90 LHHFNFKEK-CSAVKFSPDGRLFALASGRFLQIWKTPDVNKDRQFAPFVRHRVHAGHFQD 148 Query: 146 LSCCRFLDDNQ-IVTSSGDTTCALWDIETGQQT---TTFTGHTGDVMSLSLAPDTRLFVS 201 ++ + D++ I+T+S D + +W +++ ++ TTF GH VM + D + Sbjct: 149 ITSLTWSQDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGAFFSHDQEKIYT 208 Query: 202 GACDASAKLW-----------------------DVREGMCRQT----FTGHESDINAICF 234 + D + +W D+ + R T F +++ + + F Sbjct: 209 VSKDGAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQAKVKCVTF 268 Query: 235 FPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDF-N 293 P A G RL+DL + S + +VS +++G L G Sbjct: 269 HPATRLLAVGFTSGEFRLYDLPDFTLIQQLSMGQ--NPVNTVSVNQTGEWLAFGSSKLGQ 326 Query: 294 CNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 V++ GH + + L + DG V T S D +K+W+ Sbjct: 327 LLVYEWQSESYILKQQGHFDSTNSLAYSPDGSRVVTASEDGKIKVWD 373 Score = 41.2 bits (95), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 64/315 (20%), Positives = 111/315 (35%), Gaps = 67/315 (21%) Query: 71 VSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVAC-----GGL------DN 119 ++ S DGK ++ S N+V L ++ T Y N A G L D Sbjct: 20 ITFSDDGKQLL--SPVGNRVSVFDLINNKSFTFEYEHRKNIAAIDLNKQGTLLISIDEDG 77 Query: 120 ICSIYNLKTREGNVRVSRELAGHTGYLSCC---RFLDDNQIVTSSGDTTCALW---DIET 173 + N K +R + H + C +F D ++ + +W D+ Sbjct: 78 RAILVNFK--------ARNVLHHFNFKEKCSAVKFSPDGRLFALASGRFLQIWKTPDVNK 129 Query: 174 GQQTTTFT------GHTGDVMSLSLAPDTRLFVSGACDASAKLWDV---REGMCRQTFTG 224 +Q F GH D+ SL+ + D+R ++ + D SAK+W V + + TF G Sbjct: 130 DRQFAPFVRHRVHAGHFQDITSLTWSQDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNG 189 Query: 225 HESDINAICFFPNGNAFATGSDDATCRLFDL----------------------------R 256 H + F + T S D +++ R Sbjct: 190 HRDYVMGAFFSHDQEKIYTVSKDGAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWR 249 Query: 257 ADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVS 316 ++ Y++ + V+F + RLL G+ ++D L+ N V+ Sbjct: 250 ITKKHFFYANQ---AKVKCVTFHPATRLLAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVN 306 Query: 317 CLGVTDDGMAVATGS 331 + V G +A GS Sbjct: 307 TVSVNQTGEWLAFGS 321 >5FL8-q nrPDB Length = 515 Score = 86.7 bits (213), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 78/336 (23%), Positives = 150/336 (44%), Gaps = 30/336 (8%) Query: 23 KACADATLSQITNNIDP--VGRIQMRTRRT--LRGH----LAKIYAMHWGTDSRLLVSAS 74 K ++T QIT P V +++ TR + + GH L +A H T SR+ V+ + Sbjct: 107 KPGYNSTEDQITLLYTPRAVFKVKPVTRSSSAIAGHGSTILCSAFAPH--TSSRM-VTGA 163 Query: 75 QDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVR 134 D IWD T +H + +WV+ +++P G +A G +DN +++ K+ + Sbjct: 164 GDNTARIWDCDTQTPMHTLKGHYNWVLCVSWSPDGEVIATGSMDNTIRLWDPKSGQC--- 220 Query: 135 VSRELAGHTGYLSCCRFLD--------DNQIVTSSGDTTCALWDIETGQQTTTFTGHTGD 186 + L GH+ +++ + ++ +SS D T +WD + T +GHT Sbjct: 221 LGDALRGHSKWITSLSWEPIHLVKPGSKPRLASSSKDGTIKIWDTVSRVCQYTMSGHTNS 280 Query: 187 VMSLSLAPDTRLFVSGACDASAKLWDVR-EGMCRQTFTGHESDINAICFFPNGNAFATGS 245 V + L+ SG+ D + ++WD+ +G C H +N + + A G+ Sbjct: 281 VSCVKWGGQGLLY-SGSHDRTVRVWDINSQGRCINILKSHAHWVNHLSLSTD-YALRIGA 338 Query: 246 DDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRA 305 D T + + + + IC S +++ DD+ +W+ LK+ + Sbjct: 339 FDHTGKKPSTPEEAQKKALENYEKICKKN----GNSEEMMVTASDDYTMFLWNPLKSTKP 394 Query: 306 -GVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 + GH V+ + + DG + + S+D+ +K+W+ Sbjct: 395 IARMTGHQKLVNHVAFSPDGRYIVSASFDNSIKLWD 430 Score = 67.4 bits (163), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 63/259 (24%), Positives = 117/259 (45%), Gaps = 29/259 (11%) Query: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNK-VHAIPLRSSWV----MTCA 104 T+ GH + + WG LL S S D + +WD + + ++ + + WV ++ Sbjct: 273 TMSGHTNSVSCVKWGGQG-LLYSGSHDRTVRVWDINSQGRCINILKSHAHWVNHLSLSTD 331 Query: 105 YAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQ--IVTSSG 162 YA + G D+ T E + + E Y C+ +++ +VT+S Sbjct: 332 YA-----LRIGAFDHTGK--KPSTPEEAQKKALE-----NYEKICKKNGNSEEMMVTASD 379 Query: 163 DTTCALWD-IETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQT 221 D T LW+ +++ + TGH V ++ +PD R VS + D S KLWD R+G T Sbjct: 380 DYTMFLWNPLKSTKPIARMTGHQKLVNHVAFSPDGRYIVSASFDNSIKLWDGRDGKFIST 439 Query: 222 FTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQ---ELMTYSHDNIICGITSVSF 278 F GH + + + + + + S D T +++D+R + +L + + + +V + Sbjct: 440 FRGHVASVYQVAWSSDCRLLVSCSKDTTLKVWDVRTRKLSVDLPGHKDE-----VYTVDW 494 Query: 279 SKSGRLLLAGYDDFNCNVW 297 S G+ + +G D +W Sbjct: 495 SVDGKRVCSGGKDKMVRLW 513 >3DM0-A nrPDB Length = 694 Score = 86.7 bits (213), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 71/271 (26%), Positives = 119/271 (43%), Gaps = 25/271 (9%) Query: 48 RRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAP 107 +R L GH + + +D + +S S DG+L +WD + V++ A++ Sbjct: 423 QRRLTGHSHFVEDVVLSSDGQFALSGSWDGELRLWDLAAGVSTRRFVGHTKDVLSVAFSL 482 Query: 108 SGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDN---QIVTSSGDT 164 + D ++N E +S GH ++SC RF + IV++S D Sbjct: 483 DNRQIVSASRDRTIKLWN-TLGECKYTISEGGEGHRDWVSCVRFSPNTLQPTIVSASWDK 541 Query: 165 TCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTG 224 T +W++ + +T GHTG V +++++PD L SG D LWD+ EG + Sbjct: 542 TVKVWNLSNCKLRSTLAGHTGYVSTVAVSPDGSLCASGGKDGVVLLWDLAEGKKLYSLEA 601 Query: 225 HESDINAICFFPNGNAFATGSD--------DATCRLFDLRADQELMTYSHDN-------- 268 + S I+A+CF PN ++ ++ + DL+ D + DN Sbjct: 602 N-SVIHALCFSPNRYWLCAATEHGIKIWDLESKSIVEDLKVDLKAEAEKADNSGPAATKR 660 Query: 269 --IICGITSVSFSKSGRLLLAGYDDFNCNVW 297 I C TS+++S G L +GY D VW Sbjct: 661 KVIYC--TSLNWSADGSTLFSGYTDGVIRVW 689 Score = 84.7 bits (208), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 81/324 (25%), Positives = 141/324 (43%), Gaps = 41/324 (12%) Query: 48 RRTLRGHLAKIYAMHWGTD-SRLLVSASQDGKLIIWDSYTTNKVHAIPLR-----SSWVM 101 + T+R H + A+ D + ++VSAS+D +I+W +K + + R S +V Sbjct: 375 KGTMRAHTDMVTAIATPIDNADIIVSASRDKSIILWKLTKDDKAYGVAQRRLTGHSHFVE 434 Query: 102 TCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTG-YLSCCRFLDDNQIVTS 160 + G + G D +++L +R GHT LS LD+ QIV++ Sbjct: 435 DVVLSSDGQFALSGSWDGELRLWDLAAGVS----TRRFVGHTKDVLSVAFSLDNRQIVSA 490 Query: 161 SGDTTCALWDIETGQQTTTFT----GHTGDVMSLSLAPDT--RLFVSGACDASAKLWDVR 214 S D T LW+ G+ T + GH V + +P+T VS + D + K+W++ Sbjct: 491 SRDRTIKLWNT-LGECKYTISEGGEGHRDWVSCVRFSPNTLQPTIVSASWDKTVKVWNLS 549 Query: 215 EGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGIT 274 R T GH ++ + P+G+ A+G D L+DL ++L + +++ I Sbjct: 550 NCKLRSTLAGHTGYVSTVAVSPDGSLCASGGKDGVVLLWDLAEGKKLYSLEANSV---IH 606 Query: 275 SVSFSKSGRLLLAGYDDFNCNVWD-----------------ALKADRAGVLAGHDNRVSC 317 ++ FS + R L + +WD A KAD +G A + C Sbjct: 607 ALCFSPN-RYWLCAATEHGIKIWDLESKSIVEDLKVDLKAEAEKADNSGPAATKRKVIYC 665 Query: 318 --LGVTDDGMAVATGSWDSFLKIW 339 L + DG + +G D +++W Sbjct: 666 TSLNWSADGSTLFSGYTDGVIRVW 689 Score = 33.9 bits (76), Expect = 0.11, Method: Compositional matrix adjust. Identities = 20/84 (23%), Positives = 41/84 (48%), Gaps = 2/84 (2%) Query: 46 RTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAY 105 + R TL GH + + D L S +DG +++WD K++++ S C + Sbjct: 552 KLRSTLAGHTGYVSTVAVSPDGSLCASGGKDGVVLLWDLAEGKKLYSLEANSVIHALC-F 610 Query: 106 APSGNYVACGGLDNICSIYNLKTR 129 +P+ Y C ++ I++L+++ Sbjct: 611 SPN-RYWLCAATEHGIKIWDLESK 633 >4V6W-Ag nrPDB Length = 318 Score = 86.3 bits (212), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 72/261 (27%), Positives = 115/261 (44%), Gaps = 17/261 (6%) Query: 48 RRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAP 107 ++ L GH I + +D +S S D L +WD + V++ A++ Sbjct: 57 QKRLYGHSHFISDVVLSSDGNYALSGSWDQTLRLWDLAAGKTTRRFEGHTKDVLSVAFSA 116 Query: 108 SGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDD--NQIVTSSG-DT 164 + G D ++N + + + GHT ++SC RF + N I+ S G D Sbjct: 117 DNRQIVSGSRDKTIKLWNTL---AECKFTIQEDGHTDWVSCVRFSPNHSNPIIVSCGWDR 173 Query: 165 TCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTG 224 T +W++ + GH G + +++++PD L SG D+ A LWD+ +G T Sbjct: 174 TVKVWNLANCKLKNNHHGHNGYLNTVTVSPDGSLCTSGGKDSKALLWDLNDGKNLYTLE- 232 Query: 225 HESDINAICFFPNGNAF--ATGSD----DATCR--LFDLRADQELMTYSHDNIICGITSV 276 H INA+CF PN A G D C+ + +LR + T D C S+ Sbjct: 233 HNDIINALCFSPNRYWLCVAYGPSIKIWDLACKKTVEELRPEVVSPTSKADQPQC--LSL 290 Query: 277 SFSKSGRLLLAGYDDFNCNVW 297 ++S G+ L AGY D VW Sbjct: 291 AWSTDGQTLFAGYSDNTIRVW 311 Score = 80.1 bits (196), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 77/318 (24%), Positives = 138/318 (43%), Gaps = 34/318 (10%) Query: 45 MRTRRTLRGHLAKIYAMHWGT-DSRLLVSASQDGKLIIWD---------SYTTNKVHAIP 94 ++ R TL GH + + D ++SAS+D LI+W Y +++ Sbjct: 5 LQLRGTLIGHNGWVTQIATNPKDPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRLYG-- 62 Query: 95 LRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTG-YLSCCRFLD 153 S ++ + GNY G D +++L + +R GHT LS D Sbjct: 63 -HSHFISDVVLSSDGNYALSGSWDQTLRLWDLAAG----KTTRRFEGHTKDVLSVAFSAD 117 Query: 154 DNQIVTSSGDTTCALWD-IETGQQTTTFTGHTGDVMSLSLAPD--TRLFVSGACDASAKL 210 + QIV+ S D T LW+ + + T GHT V + +P+ + VS D + K+ Sbjct: 118 NRQIVSGSRDKTIKLWNTLAECKFTIQEDGHTDWVSCVRFSPNHSNPIIVSCGWDRTVKV 177 Query: 211 WDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNII 270 W++ + GH +N + P+G+ +G D+ L+DL + L T H++I Sbjct: 178 WNLANCKLKNNHHGHNGYLNTVTVSPDGSLCTSGGKDSKALLWDLNDGKNLYTLEHNDI- 236 Query: 271 CGITSVSFSKSGRLLLAGYDDFNCNVWD-----ALKADRAGVLA--GHDNRVSCLGV--T 321 I ++ FS + L Y + +WD ++ R V++ ++ CL + + Sbjct: 237 --INALCFSPNRYWLCVAYGP-SIKIWDLACKKTVEELRPEVVSPTSKADQPQCLSLAWS 293 Query: 322 DDGMAVATGSWDSFLKIW 339 DG + G D+ +++W Sbjct: 294 TDGQTLFAGYSDNTIRVW 311 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 52/212 (24%), Positives = 95/212 (44%), Gaps = 11/212 (5%) Query: 139 LAGHTGYLS--CCRFLDDNQIVTSSGDTTCALW------DIETGQQTTTFTGHTGDVMSL 190 L GH G+++ D + I+++S D T +W D G GH+ + + Sbjct: 11 LIGHNGWVTQIATNPKDPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRLYGHSHFISDV 70 Query: 191 SLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATC 250 L+ D +SG+ D + +LWD+ G + F GH D+ ++ F + +GS D T Sbjct: 71 VLSSDGNYALSGSWDQTLRLWDLAAGKTTRRFEGHTKDVLSVAFSADNRQIVSGSRDKTI 130 Query: 251 RLFDLRADQELMTYSHDNIICGITSVSFSK--SGRLLLAGYDDFNCNVWDALKADRAGVL 308 +L++ A+ + T D ++ V FS S ++++ D VW+ Sbjct: 131 KLWNTLAECKF-TIQEDGHTDWVSCVRFSPNHSNPIIVSCGWDRTVKVWNLANCKLKNNH 189 Query: 309 AGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 GH+ ++ + V+ DG +G DS +W+ Sbjct: 190 HGHNGYLNTVTVSPDGSLCTSGGKDSKALLWD 221 >3JB9-L nrPDB Length = 340 Score = 81.6 bits (200), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 71/269 (26%), Positives = 120/269 (44%), Gaps = 59/269 (21%) Query: 100 VMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVT 159 V+ + PSG+Y A GG+D ++N+ G+V+ L G G ++ ++ D+++V Sbjct: 53 VLVARFDPSGSYFASGGMDRQILLWNV---FGDVKNYGVLNGCKGAITDLQWSRDSRVVY 109 Query: 160 -SSGDTTCALWDIETGQQTTTFTGHTGDVMSL-----------SLAPD------------ 195 SS DT WD +GQ+ GH G V +L S++ D Sbjct: 110 CSSSDTHLMSWDAVSGQKIRKHKGHAGVVNALDVLKVGSELLTSVSDDCTMKVWDSRSKD 169 Query: 196 --------------------TRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFF 235 T++F+ G D + K+WD+R C GH+ I ++ Sbjct: 170 CIKTIEEKYPLTAVAIAQQGTQVFI-GGIDGAIKIWDLRNNHCSHVLKGHKDIITSLAIS 228 Query: 236 PNGNAFATGSDDATCRLFDLR----ADQELMTYSHDNIICG----ITSVSFSKSGRLLLA 287 +G++ + S D T R+FD++ A ++L + + I G + V++S++ R + A Sbjct: 229 KDGSSLLSNSMDNTVRIFDVKPFASAQRQLQIF--EGAIHGQEHNLLGVAWSRNSRFVGA 286 Query: 288 GYDDFNCNVWDALKADRAGVLAGHDNRVS 316 G D N VW A D VL GH+ V+ Sbjct: 287 GSSDKNVYVWSA-TGDLRYVLPGHEGSVN 314 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 49/206 (23%), Positives = 90/206 (43%), Gaps = 6/206 (2%) Query: 138 ELAGHTGYLSCCRFLDDNQIVTSSG-DTTCALWDIETG-QQTTTFTGHTGDVMSLSLAPD 195 ++ GHT + RF S G D LW++ + G G + L + D Sbjct: 45 QMFGHTAEVLVARFDPSGSYFASGGMDRQILLWNVFGDVKNYGVLNGCKGAITDLQWSRD 104 Query: 196 TRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATG-SDDATCRLFD 254 +R+ + D WD G + GH +NA+ G+ T SDD T +++D Sbjct: 105 SRVVYCSSSDTHLMSWDAVSGQKIRKHKGHAGVVNALDVLKVGSELLTSVSDDCTMKVWD 164 Query: 255 LRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNR 314 R+ + T +T+V+ ++ G + G D +WD + VL GH + Sbjct: 165 SRSKDCIKTIEEK---YPLTAVAIAQQGTQVFIGGIDGAIKIWDLRNNHCSHVLKGHKDI 221 Query: 315 VSCLGVTDDGMAVATGSWDSFLKIWN 340 ++ L ++ DG ++ + S D+ ++I++ Sbjct: 222 ITSLAISKDGSSLLSNSMDNTVRIFD 247 Score = 62.8 bits (151), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 53/217 (24%), Positives = 97/217 (44%), Gaps = 16/217 (7%) Query: 49 RTLRGHLAKIYAMH-WGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAP 107 R +GH + A+ S LL S S D + +WDS + + + I + + A A Sbjct: 129 RKHKGHAGVVNALDVLKVGSELLTSVSDDCTMKVWDSRSKDCIKTIEEKYP-LTAVAIAQ 187 Query: 108 SGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDD-NQIVTSSGDTTC 166 G V GG+D I++L+ N S L GH ++ D + ++++S D T Sbjct: 188 QGTQVFIGGIDGAIKIWDLR----NNHCSHVLKGHKDIITSLAISKDGSSLLSNSMDNTV 243 Query: 167 ALWDIE----TGQQTTTFTG----HTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMC 218 ++D++ +Q F G +++ ++ + ++R +G+ D + +W G Sbjct: 244 RIFDVKPFASAQRQLQIFEGAIHGQEHNLLGVAWSRNSRFVGAGSSDKNVYVWSA-TGDL 302 Query: 219 RQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDL 255 R GHE +N + F P+ + + S D T L +L Sbjct: 303 RYVLPGHEGSVNHVDFHPHQDIILSCSSDRTIFLGEL 339 >6HHQ-h nrPDB Length = 319 Score = 80.9 bits (198), Expect = 8e-16, Method: Compositional matrix adjust. Identities = 78/313 (24%), Positives = 130/313 (41%), Gaps = 28/313 (8%) Query: 48 RRTLRGHLAKIYAMHWGT-DSRLLVSASQDGKLIIWDSYTTNKVHAIPLR-----SSWVM 101 R TL GH + ++ LL+SAS+D LI W ++ +P+R S V Sbjct: 10 RGTLEGHNGWVTSLATSAGQPNLLLSASRDKTLISWKLTGDDQKFGVPVRSFKGHSHIVQ 69 Query: 102 TCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGH-TGYLSCCRFLDDNQIVTS 160 C G Y D ++++ T E R GH + +S + I++ Sbjct: 70 DCTLTADGAYALSASWDKTLRLWDVATGETYQR----FVGHKSDVMSVDIDKKASMIISG 125 Query: 161 SGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAP------DTRLFVSGACDASAKLWDVR 214 S D T +W I+ GQ T GH V + + P D+ +S D K W++ Sbjct: 126 SRDKTIKVWTIK-GQCLATLLGHNDWVSQVRVVPNEKADDDSVTIISAGNDKMVKAWNLN 184 Query: 215 EGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGIT 274 + F GH S+IN + P+G A+ D L++L A + + T S + + Sbjct: 185 QFQIEADFIGHNSNINTLTASPDGTLIASAGKDGEIMLWNLAAKKAMYTLSAQDEVF--- 241 Query: 275 SVSFSKSGRLLLA----GYDDFNCN---VWDALKADRAGVLAGHDNRVSCLGVTDDGMAV 327 S++FS + L A G F+ + + D L+ + AG + L + DG + Sbjct: 242 SLAFSPNRYWLAAATATGIKVFSLDPQYLVDDLRPEFAGYSKAAEPHAVSLAWSADGQTL 301 Query: 328 ATGSWDSFLKIWN 340 G D+ +++W Sbjct: 302 FAGYTDNVIRVWQ 314 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 68/270 (25%), Positives = 109/270 (40%), Gaps = 24/270 (8%) Query: 49 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPS 108 R+ +GH + D +SAS D L +WD T S VM+ Sbjct: 59 RSFKGHSHIVQDCTLTADGAYALSASWDKTLRLWDVATGETYQRFVGHKSDVMSVDIDKK 118 Query: 109 GNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFL------DDNQIVTSSG 162 + + G D ++ +K + L GH ++S R + DD+ + S+G Sbjct: 119 ASMIISGSRDKTIKVWTIKG-----QCLATLLGHNDWVSQVRVVPNEKADDDSVTIISAG 173 Query: 163 -DTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQT 221 D W++ Q F GH ++ +L+ +PD L S D LW++ T Sbjct: 174 NDKMVKAWNLNQFQIEADFIGHNSNINTLTASPDGTLIASAGKDGEIMLWNLAAKKAMYT 233 Query: 222 FTGHESDINAICFFPN----GNAFATG----SDDATCRLFDLRADQELMTYSHDNIICGI 273 + + ++ ++ F PN A ATG S D + DLR E YS + Sbjct: 234 LSAQD-EVFSLAFSPNRYWLAAATATGIKVFSLDPQYLVDDLRP--EFAGYSKAAEPHAV 290 Query: 274 TSVSFSKSGRLLLAGYDDFNCNVWDALKAD 303 S+++S G+ L AGY D VW + A+ Sbjct: 291 -SLAWSADGQTLFAGYTDNVIRVWQVMTAN 319 >5Y88-O nrPDB Length = 451 Score = 80.1 bits (196), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 49/200 (24%), Positives = 88/200 (44%), Gaps = 6/200 (3%) Query: 134 RVSRELAGHTGYLSCCRF--LDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLS 191 ++SR + GH G++ C +D+ +T S DTT +WD+ TG+ TT GH V ++ Sbjct: 130 KLSRVINGHLGWVRCVAIDPVDNEWFITGSNDTTMKVWDLATGKLKTTLAGHVMTVRDVA 189 Query: 192 LAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCR 251 ++ S + D + K WD+ + + + GH S + + P + AT D+ + Sbjct: 190 VSDRHPYLFSVSEDKTVKCWDLEKNQIIRDYYGHLSGVRTVSIHPTLDLIATAGRDSVIK 249 Query: 252 LFDLRADQELMTY-SHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAG 310 L+D+R ++T H I V + +++ D +WD + VL Sbjct: 250 LWDMRTRIPVITLVGHKG---PINQVQCTPVDPQVVSSSTDATVRLWDVVAGKTMKVLTH 306 Query: 311 HDNRVSCLGVTDDGMAVATG 330 H V + +VA+ Sbjct: 307 HKRSVRATALHPKEFSVASA 326 Score = 77.4 bits (189), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 63/259 (24%), Positives = 108/259 (41%), Gaps = 12/259 (4%) Query: 46 RTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAY 105 + + TL GH+ + + L S S+D + WD + S V T + Sbjct: 173 KLKTTLAGHVMTVRDVAVSDRHPYLFSVSEDKTVKCWDLEKNQIIRDYYGHLSGVRTVSI 232 Query: 106 APSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLD-DNQIVTSSGDT 164 P+ + +A G D++ +++++TR + L GH G ++ + D Q+V+SS D Sbjct: 233 HPTLDLIATAGRDSVIKLWDMRTRIPVI----TLVGHKGPINQVQCTPVDPQVVSSSTDA 288 Query: 165 TCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTG 224 T LWD+ G+ T H V + +L P V+ AC + W + EG F Sbjct: 289 TVRLWDVVAGKTMKVLTHHKRSVRATALHPK-EFSVASACTDDIRSWGLAEGSLLTNFES 347 Query: 225 HESDINAICFFPNGNAFATGSDDATCRLFDLRAD---QELMTYSHDNIICGITSV---SF 278 ++ I + G D+ +D ++ Q L T + G SV +F Sbjct: 348 EKTGIINTLSINQDDVLFAGGDNGVLSFYDYKSGHKYQSLATREMVGSLEGERSVLCSTF 407 Query: 279 SKSGRLLLAGYDDFNCNVW 297 K+G L+ G D + +W Sbjct: 408 DKTGLRLITGEADKSIKIW 426 Score = 67.4 bits (163), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 70/291 (24%), Positives = 110/291 (37%), Gaps = 53/291 (18%) Query: 99 WVMTCAYAPSGN-YVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQI 157 WV A P N + G D +++L T G ++ + LAGH + D + Sbjct: 141 WVRCVAIDPVDNEWFITGSNDTTMKVWDLAT--GKLKTT--LAGHVMTVRDVAVSDRHPY 196 Query: 158 VTS-SGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREG 216 + S S D T WD+E Q + GH V ++S+ P L + D+ KLWD+R Sbjct: 197 LFSVSEDKTVKCWDLEKNQIIRDYYGHLSGVRTVSIHPTLDLIATAGRDSVIKLWDMRTR 256 Query: 217 MCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSV 276 + T GH+ IN + P + S DAT RL+D+ A + + +H T++ Sbjct: 257 IPVITLVGHKGPINQVQCTPVDPQVVSSSTDATVRLWDVVAGKTMKVLTHHKRSVRATAL 316 Query: 277 ----------------SFSKSGRLLLAGYDDFNCNVWDALKADRAGVL-AGHDN------ 313 S+ + LL ++ + + L ++ VL AG DN Sbjct: 317 HPKEFSVASACTDDIRSWGLAEGSLLTNFESEKTGIINTLSINQDDVLFAGGDNGVLSFY 376 Query: 314 ------------------------RVSCLGVTDDGMAVATGSWDSFLKIWN 340 V C G+ + TG D +KIW Sbjct: 377 DYKSGHKYQSLATREMVGSLEGERSVLCSTFDKTGLRLITGEADKSIKIWK 427 Score = 57.4 bits (137), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 38/160 (23%), Positives = 71/160 (44%), Gaps = 3/160 (1%) Query: 182 GHTGDVMSLSLAP-DTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNA 240 GH G V +++ P D F++G+ D + K+WD+ G + T GH + + Sbjct: 137 GHLGWVRCVAIDPVDNEWFITGSNDTTMKVWDLATGKLKTTLAGHVMTVRDVAVSDRHPY 196 Query: 241 FATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDAL 300 + S+D T + +DL +Q + Y + G+ +VS + L+ D +WD Sbjct: 197 LFSVSEDKTVKCWDLEKNQIIRDYY--GHLSGVRTVSIHPTLDLIATAGRDSVIKLWDMR 254 Query: 301 KADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 L GH ++ + T V + S D+ +++W+ Sbjct: 255 TRIPVITLVGHKGPINQVQCTPVDPQVVSSSTDATVRLWD 294 >6ID0-T nrPDB Length = 514 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 53/209 (25%), Positives = 91/209 (43%), Gaps = 6/209 (2%) Query: 134 RVSRELAGHTGYLSCCRFLDDNQ-IVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSL 192 ++ R ++GH G++ C NQ VT S D T +WD+ +G+ + TGH V + + Sbjct: 195 KLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIV 254 Query: 193 APDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRL 252 + + S D K WD+ + + GH S + + P + T S D+T R+ Sbjct: 255 STRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARI 314 Query: 253 FDLRADQELMTYS-HDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGH 311 +D+R + T S H N + +V + ++ G D +WD + L H Sbjct: 315 WDVRTKASVHTLSGHTN---AVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNH 371 Query: 312 DNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 V + + A+GS D+ +K W Sbjct: 372 KKSVRAVVLHPRHYTFASGSPDN-IKQWK 399 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 57/212 (26%), Positives = 97/212 (45%), Gaps = 7/212 (3%) Query: 46 RTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAY 105 + + +L GH++ + + T S L S +D ++ WD + S V Sbjct: 237 KLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDL 296 Query: 106 APSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCR-FLDDNQIVTSSGDT 164 P+ + + D+ I++++T+ L+GHT ++ R + QI+T S DT Sbjct: 297 HPTIDVLVTCSRDSTARIWDVRTKAS----VHTLSGHTNAVATVRCQAAEPQIITGSHDT 352 Query: 165 TCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTG 224 T LWD+ G+ T T H V ++ L P F SG+ D + K W +G Q +G Sbjct: 353 TIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPD-NIKQWKFPDGSFIQNLSG 411 Query: 225 HESDINAICFFPNGNAFATGSDDATCRLFDLR 256 H + IN + +G +G+D+ T L+D R Sbjct: 412 HNAIINTLTVNSDG-VLVSGADNGTMHLWDWR 442 Score = 75.5 bits (184), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 64/254 (25%), Positives = 109/254 (42%), Gaps = 15/254 (5%) Query: 49 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPS 108 R + GHL + + ++ V+ S D + IWD + ++ S V + Sbjct: 198 RVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTR 257 Query: 109 GNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQ----IVTSSGDT 164 Y+ G D ++L+ +V R GH LS LD + +VT S D+ Sbjct: 258 SPYLFSCGEDKQVKCWDLEYN----KVIRHYHGH---LSAVYGLDLHPTIDVLVTCSRDS 310 Query: 165 TCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTG 224 T +WD+ T T +GHT V ++ ++G+ D + +LWD+ G R T T Sbjct: 311 TARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTN 370 Query: 225 HESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRL 284 H+ + A+ P FA+GS D + + + S N I +V+ S + Sbjct: 371 HKKSVRAVVLHPRHYTFASGSPD-NIKQWKFPDGSFIQNLSGHNAIINTLTVN---SDGV 426 Query: 285 LLAGYDDFNCNVWD 298 L++G D+ ++WD Sbjct: 427 LVSGADNGTMHLWD 440 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 51/220 (23%), Positives = 82/220 (37%), Gaps = 8/220 (3%) Query: 49 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPS 108 R GHL+ +Y + +LV+ S+D IWD T VH + ++ V T + Sbjct: 282 RHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAA 341 Query: 109 GNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCAL 168 + G D +++L G RV+ L H + + S Sbjct: 342 EPQIITGSHDTTIRLWDLVA--GKTRVT--LTNHKKSVRAVVLHPRHYTFASGSPDNIKQ 397 Query: 169 WDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESD 228 W G +GH + +L++ D + VSGA + + LWD R G F + Sbjct: 398 WKFPDGSFIQNLSGHNAIINTLTVNSDG-VLVSGADNGTMHLWDWRTGY---NFQRVHAA 453 Query: 229 INAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDN 268 + FA D + RL AD+ + Y D+ Sbjct: 454 VQPGSLDSESGIFACAFDQSESRLLTAEADKTIKVYREDD 493 >5FVM-C nrPDB Length = 303 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 51/196 (26%), Positives = 91/196 (46%), Gaps = 12/196 (6%) Query: 154 DNQIVTSSGDTTCALWDIETGQQ--TTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLW 211 D + + ++G L+DI + ++F GH G+V S++ + R VS + D + K+W Sbjct: 43 DKKYLAAAGHLHVRLYDIRSNNPNPVSSFEGHKGNVTSIAFQQENRWMVSSSEDGTIKVW 102 Query: 212 DVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQ-ELMTYSHDNII 270 DVR ++ + H + +N + PN + D R++DL +Q DN Sbjct: 103 DVRSPSVQRNYK-HNAPVNEVAIHPNQGELISCDQDGNIRIWDLGENQCTNQLTPEDNT- 160 Query: 271 CGITSVSFSKSGRLLLAGYDDFNCNVW------DALKADRAGVLAGHDNRVSCLGVTDDG 324 + S+S + G +L+AG + NC VW DA + H ++ + ++ D Sbjct: 161 -PLQSLSVASDGSMLVAGNNKGNCYVWRMPHHTDASTLEPVTKFKSHTKYITRVLLSADV 219 Query: 325 MAVATGSWDSFLKIWN 340 +AT S D ++WN Sbjct: 220 KNLATCSADHTARVWN 235 Score = 62.0 bits (149), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 55/251 (21%), Positives = 104/251 (41%), Gaps = 28/251 (11%) Query: 34 TNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWD----SYTTNK 89 +NN +PV + GH + ++ + ++R +VS+S+DG + +WD S N Sbjct: 62 SNNPNPVS--------SFEGHKGNVTSIAFQQENRWMVSSSEDGTIKVWDVRSPSVQRNY 113 Query: 90 VHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCC 149 H P+ + G ++C NI I++L + +++ E +T S Sbjct: 114 KHNAPVNE----VAIHPNQGELISCDQDGNI-RIWDLGENQCTNQLTPE--DNTPLQSLS 166 Query: 150 RFLDDNQIVTSSGDTTCALW------DIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGA 203 D + +V + C +W D T + T F HT + + L+ D + + + Sbjct: 167 VASDGSMLVAGNNKGNCYVWRMPHHTDASTLEPVTKFKSHTKYITRVLLSADVKNLATCS 226 Query: 204 CDASAKLWDVREG-MCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELM 262 D +A++W++ + T GH+ + F + T D RL+DL + + Sbjct: 227 ADHTARVWNIEDNYQLETTLDGHQRWVWDCAFSADSAYLVTACSDHYVRLWDLSTSEIVR 286 Query: 263 TY--SHDNIIC 271 Y H +C Sbjct: 287 QYGGHHKGAVC 297 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 60/306 (19%), Positives = 108/306 (35%), Gaps = 55/306 (17%) Query: 67 SRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNL 126 S +L SA D + W++ T I S V Y+A G ++ +Y++ Sbjct: 2 SVILASAGYDHTIRFWEALTGVCSRTIQHADSQVNRLEITSDKKYLAAAGHLHV-RLYDI 60 Query: 127 KTREGNVRVSRELAGHTGYLSCCRFLDDNQ-IVTSSGDTTCALWDIETGQQTTTFTGHTG 185 ++ N S E GH G ++ F +N+ +V+SS D T +WD+ + + H Sbjct: 61 RSNNPNPVSSFE--GHKGNVTSIAFQQENRWMVSSSEDGTIKVWDVRSPSVQRNYK-HNA 117 Query: 186 DVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQ------------------------- 220 V +++ P+ +S D + ++WD+ E C Sbjct: 118 PVNEVAIHPNQGELISCDQDGNIRIWDLGENQCTNQLTPEDNTPLQSLSVASDGSMLVAG 177 Query: 221 ------------------------TFTGHESDINAICFFPNGNAFATGSDDATCRLFDLR 256 F H I + + AT S D T R++++ Sbjct: 178 NNKGNCYVWRMPHHTDASTLEPVTKFKSHTKYITRVLLSADVKNLATCSADHTARVWNIE 237 Query: 257 ADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVS 316 + +L T + D + +FS L+ D +WD ++ GH Sbjct: 238 DNYQLET-TLDGHQRWVWDCAFSADSAYLVTACSDHYVRLWDLSTSEIVRQYGGHHKGAV 296 Query: 317 CLGVTD 322 C+ + D Sbjct: 297 CVALND 302 Score = 37.4 bits (85), Expect = 0.008, Method: Compositional matrix adjust. Identities = 29/136 (21%), Positives = 56/136 (41%), Gaps = 10/136 (7%) Query: 64 GTDSRLLVSASQDGKLIIW------DSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGL 117 +D +LV+ + G +W D+ T V + ++ + +A Sbjct: 168 ASDGSMLVAGNNKGNCYVWRMPHHTDASTLEPVTKFKSHTKYITRVLLSADVKNLATCSA 227 Query: 118 DNICSIYNLKTREGNVRVSRELAGHTGYLSCCRF-LDDNQIVTSSGDTTCALWDIETGQQ 176 D+ ++N+ E N ++ L GH ++ C F D +VT+ D LWD+ T + Sbjct: 228 DHTARVWNI---EDNYQLETTLDGHQRWVWDCAFSADSAYLVTACSDHYVRLWDLSTSEI 284 Query: 177 TTTFTGHTGDVMSLSL 192 + GH + ++L Sbjct: 285 VRQYGGHHKGAVCVAL 300 >5WYK-BB nrPDB Length = 943 Score = 75.5 bits (184), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 55/224 (24%), Positives = 93/224 (41%), Gaps = 21/224 (9%) Query: 53 GHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKV---------------HAIPLRS 97 H A I+++ +D + LV+ S D + WD N + H L Sbjct: 471 AHDAAIWSLDLTSDGKRLVTGSADKTVKFWDFKVENSLVPGTKNKFLPVLKLHHDTTLEL 530 Query: 98 SWVMTCA-YAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHT-GYLSCCRFLDDN 155 + + C +P Y+A LDN ++ L + ++ L GH LS D Sbjct: 531 TDDILCVRVSPDDRYLAISLLDNTVKVFFLDS----MKFYLSLYGHKLPVLSIDISFDSK 586 Query: 156 QIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVRE 215 I+TSS D +W ++ G + H +M++ P + F S + DA K WD + Sbjct: 587 MIITSSADKNIKIWGLDFGDCHKSLFAHQDSIMNVKFLPQSHNFFSCSKDAVVKYWDGEK 646 Query: 216 GMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQ 259 C Q H+S++ A+ +G + S D + R+++ DQ Sbjct: 647 FECIQKLYAHQSEVWALAVATDGGFVVSSSHDHSIRIWEETEDQ 690 Score = 64.3 bits (155), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 69/321 (21%), Positives = 123/321 (38%), Gaps = 26/321 (8%) Query: 38 DPVGRIQMRTRRT-LRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLR 96 DP ++T L+G + ++ D++LL +AS +G L IW+ T + Sbjct: 373 DPTSPAPLKTHTIELQGQRTDVRSIDISDDNKLLATAS-NGSLKIWNIKTHKCIRT--FE 429 Query: 97 SSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQ 156 + +TC + P G V G + +++L + ++ + E A S D + Sbjct: 430 CGYALTCKFLPGGLLVILGTRNGELQLFDLAS--SSLLDTIEDAHDAAIWSLDLTSDGKR 487 Query: 157 IVTSSGDTTCALWDIETGQQTTTFTGH----------------TGDVMSLSLAPDTRLFV 200 +VT S D T WD + T + T D++ + ++PD R Sbjct: 488 LVTGSADKTVKFWDFKVENSLVPGTKNKFLPVLKLHHDTTLELTDDILCVRVSPDDRYLA 547 Query: 201 SGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLR-ADQ 259 D + K++ + + GH+ + +I + T S D +++ L D Sbjct: 548 ISLLDNTVKVFFLDSMKFYLSLYGHKLPVLSIDISFDSKMIITSSADKNIKIWGLDFGDC 607 Query: 260 ELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLG 319 ++H + I +V F + D WD K + L H + V L Sbjct: 608 HKSLFAHQD---SIMNVKFLPQSHNFFSCSKDAVVKYWDGEKFECIQKLYAHQSEVWALA 664 Query: 320 VTDDGMAVATGSWDSFLKIWN 340 V DG V + S D ++IW Sbjct: 665 VATDGGFVVSSSHDHSIRIWE 685 Score = 48.1 bits (113), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 49/198 (24%), Positives = 78/198 (39%), Gaps = 20/198 (10%) Query: 156 QIVTSSGDTTCALWDIETGQQTTTFT------------GHTGDVMSLSLAPDTRLFVSGA 203 Q++TS+ + +WDI+TG + + + L DT L G Sbjct: 40 QLITSALED-VNIWDIKTGDLVSKLSDGLPPGASDARGAKPAECTYLEAHKDTDLLAVGY 98 Query: 204 CDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMT 263 D K+WD+ F GH++ I + F G +GS D+ ++DL + L Sbjct: 99 ADGVIKVWDLMSKTVLLNFNGHKAAITLLQFDGTGTRLISGSKDSNIIVWDLVGEVGLYK 158 Query: 264 Y-SHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTD 322 SH + I G + + L++ D +WD H L V D Sbjct: 159 LRSHKDSITGF----WCQGEDWLISTSKDGMIKLWDLKTHQCIETHIAHTGECWGLAVKD 214 Query: 323 DGMAVATGSWDSFLKIWN 340 D + + TG+ DS +KIW Sbjct: 215 D-LLITTGT-DSQVKIWK 230 Score = 43.5 bits (101), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 43/217 (19%), Positives = 85/217 (39%), Gaps = 35/217 (16%) Query: 66 DSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYN 125 D+ LL DG + +WD + + + + + +G + G D+ +++ Sbjct: 90 DTDLLAVGYADGVIKVWDLMSKTVLLNFNGHKAAITLLQFDGTGTRLISGSKDSNIIVWD 149 Query: 126 LKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTG 185 L G ++ TG+ C+ ++ ++++S D LWD++T Q T HTG Sbjct: 150 LVGEVGLYKLRSHKDSITGF--WCQ--GEDWLISTSKDGMIKLWDLKTHQCIETHIAHTG 205 Query: 186 DVMSLSLAPDTRLFVSGACDASAKLWD----------------VREGMCRQ-----TFTG 224 + L++ D L ++ D+ K+W + E +Q F Sbjct: 206 ECWGLAVKDD--LLITTGTDSQVKIWKLDIENDKMGGKLTEMGIFEKQSKQRGLKIEFIT 263 Query: 225 HESDINAICFFPNGNAFATGSDDATCRLFDLRADQEL 261 + SD + + N D T F +R ++E+ Sbjct: 264 NSSDKTSFFYIQNA--------DKTIETFRIRKEEEI 292 Score = 32.7 bits (73), Expect = 0.25, Method: Compositional matrix adjust. Identities = 36/187 (19%), Positives = 66/187 (35%), Gaps = 47/187 (25%) Query: 30 LSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNK 89 +S + N + M+ +L GH + ++ DS++++++S D + IW Sbjct: 548 ISLLDNTVKVFFLDSMKFYLSLYGHKLPVLSIDISFDSKMIITSSADKNIKIW------- 600 Query: 90 VHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCC 149 GLD G+ + L H + Sbjct: 601 --------------------------GLDF-----------GDCH--KSLFAHQDSIMNV 621 Query: 150 RFLDDNQ-IVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASA 208 +FL + + S D WD E + H +V +L++A D VS + D S Sbjct: 622 KFLPQSHNFFSCSKDAVVKYWDGEKFECIQKLYAHQSEVWALAVATDGGFVVSSSHDHSI 681 Query: 209 KLWDVRE 215 ++W+ E Sbjct: 682 RIWEETE 688 Score = 32.3 bits (72), Expect = 0.29, Method: Compositional matrix adjust. Identities = 26/121 (21%), Positives = 48/121 (39%), Gaps = 5/121 (4%) Query: 145 YLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGAC 204 YL + D + + D +WD+ + F GH + L +SG+ Sbjct: 84 YLEAHK--DTDLLAVGYADGVIKVWDLMSKTVLLNFNGHKAAITLLQFDGTGTRLISGSK 141 Query: 205 DASAKLWDVREGMCRQTFTGHESDINAICFFPNGNA-FATGSDDATCRLFDLRADQELMT 263 D++ +WD+ + H+ I F+ G + S D +L+DL+ Q + T Sbjct: 142 DSNIIVWDLVGEVGLYKLRSHKDSITG--FWCQGEDWLISTSKDGMIKLWDLKTHQCIET 199 Query: 264 Y 264 + Sbjct: 200 H 200 >5NZU-C nrPDB Length = 905 Score = 75.1 bits (183), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 72/296 (24%), Positives = 118/296 (39%), Gaps = 17/296 (5%) Query: 42 RIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVM 101 R+ ++ + T R K +H T+ +L S +G + +W+ T V + V Sbjct: 4 RLDIKRKLTARSDRVKSVDLH-PTEPWMLASLY-NGSVCVWNHETQTLVKTFEVCDLPVR 61 Query: 102 TCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQ-IVTS 160 + N+V G D ++N T E RV H+ Y+ C I+TS Sbjct: 62 AAKFVARKNWVVTGADDMQIRVFNYNTLE---RVHM-FEAHSDYIRCIAVHPTQPFILTS 117 Query: 161 SGDTTCALWDIETGQQ-TTTFTGHTGDVMSLSLAP-DTRLFVSGACDASAKLWDVREGMC 218 S D LWD + + F GHT VM + + P D F S + D + K+W + Sbjct: 118 SDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSP 177 Query: 219 RQTFTGHESDINAICFFPNGNA--FATGSDDATCRLFDLRADQELMTYS--HDNIICGIT 274 T GHE +N I ++ G+ +G+DD +++D + + T N+ C Sbjct: 178 NFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCA-- 235 Query: 275 SVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATG 330 SF +++ G +D +W + L RV C+ VA G Sbjct: 236 --SFHPELPIIITGSEDGTVRIWHSSTYRLESTLNYGMERVWCVASLRGSNNVALG 289 Score = 70.5 bits (171), Expect = 9e-13, Method: Compositional matrix adjust. Identities = 49/191 (25%), Positives = 85/191 (44%), Gaps = 8/191 (4%) Query: 155 NQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDV- 213 N +VT + D +++ T ++ F H+ + +++ P ++ + D KLWD Sbjct: 70 NWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWD 129 Query: 214 REGMCRQTFTGHESDINAICFFP-NGNAFATGSDDATCRLFDLRADQELMTYS-HDNIIC 271 ++ C Q F GH + I P + N FA+ S D T +++ L + T H+ Sbjct: 130 KKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEK--- 186 Query: 272 GITSVSFSKSG--RLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVAT 329 G+ + + G L++G DD +WD L GH VSC + + T Sbjct: 187 GVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIIIT 246 Query: 330 GSWDSFLKIWN 340 GS D ++IW+ Sbjct: 247 GSEDGTVRIWH 257 Score = 42.0 bits (97), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 39/165 (23%), Positives = 67/165 (40%), Gaps = 8/165 (4%) Query: 180 FTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGN 239 T + V S+ L P ++ + S +W+ +TF + + A F N Sbjct: 11 LTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVARKN 70 Query: 240 AFATGSDDATCRLFDLRADQEL-MTYSH-DNIICGITSVSFSKSGRLLLAGYDDFNCNVW 297 TG+DD R+F+ + + M +H D I C ++ + +L DD +W Sbjct: 71 WVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRC----IAVHPTQPFILTSSDDMLIKLW 126 Query: 298 D-ALKADRAGVLAGHDNRVSCLGV-TDDGMAVATGSWDSFLKIWN 340 D K + V GH + V + + D A+ S D +K+W Sbjct: 127 DWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQ 171 >4GGA-A nrPDB Length = 420 Score = 74.3 bits (181), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 64/285 (22%), Positives = 129/285 (45%), Gaps = 26/285 (9%) Query: 70 LVSASQDGKLIIWDSYTTNKVHAIPLRSS--WVMTCAYAPSGNYVACGGLDNICSIYNLK 127 +++ + D + +W + + + + + + ++ + A+ GNY+A G +++++ Sbjct: 118 VLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQ 177 Query: 128 TREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALW--DIETGQQ-TTTFTGHT 184 + + R + H+ + + N + SSG + + D+ + T +GH+ Sbjct: 178 QQ----KRLRNMTSHSARVGSLSW---NSYILSSGSRSGHIHHHDVRVAEHHVATLSGHS 230 Query: 185 GDVMSLSLAPDTRLFVSGACDASAKLWDVREG----MCRQTFTGHESDINAICFFP-NGN 239 +V L APD R SG D +W G + QTFT H+ + A+ + P N Sbjct: 231 QEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSN 290 Query: 240 AFATG--SDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCN-- 295 ATG + D R++++ + L + +C S+ +S + L++G+ F N Sbjct: 291 VLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVC---SILWSPHYKELISGHG-FAQNQL 346 Query: 296 -VWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIW 339 +W + L GH +RV L ++ DG VA+ + D L++W Sbjct: 347 VIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 391 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 48/185 (25%), Positives = 75/185 (40%), Gaps = 25/185 (13%) Query: 42 RIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRS---- 97 R+ TL GH ++ + W D R L S D + +W S + +PL++ Sbjct: 217 RVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPS-APGEGGWVPLQTFTQH 275 Query: 98 -SWVMTCAYAP-SGNYVACGG--------LDNICSIYNLKTREGNVRVSREL-AGHTGYL 146 V A+ P N +A GG + N+CS L + + +V L + H L Sbjct: 276 QGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKEL 335 Query: 147 SCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDA 206 NQ+V +W T + GHT V+SL+++PD S A D Sbjct: 336 ISGHGFAQNQLV---------IWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADE 386 Query: 207 SAKLW 211 + +LW Sbjct: 387 TLRLW 391 >6EMK-B nrPDB Length = 303 Score = 73.9 bits (180), Expect = 8e-14, Method: Compositional matrix adjust. Identities = 53/215 (24%), Positives = 93/215 (43%), Gaps = 14/215 (6%) Query: 136 SRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIET--GQQTTTFTGHTGDVMSLSLA 193 SR + ++ +D +++ ++G L+DI T +F GH G+V S+S Sbjct: 25 SRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQ 84 Query: 194 PDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLF 253 D R V+ + D + K+WDVR + + H + +N + PN + D R++ Sbjct: 85 QDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAPVNEVVIHPNQGELISCDRDGNIRIW 143 Query: 254 DLRADQ--ELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVW------DALKADRA 305 DL +Q +T D + S+S + G +L A NC VW DA Sbjct: 144 DLGENQCTHQLTPEDD---TSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPV 200 Query: 306 GVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 H ++ + ++ D +AT S D ++W+ Sbjct: 201 TKFRAHSTYITRILLSSDVKHLATCSADHTARVWS 235 Score = 65.1 bits (157), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 66/286 (23%), Positives = 116/286 (40%), Gaps = 21/286 (7%) Query: 67 SRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNL 126 S +LVSA D + W++ T I S V +A G N+ +Y++ Sbjct: 2 SVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNV-RLYDI 60 Query: 127 KTREGNVRVSRELAGHTGYLSCCRFLDDNQ-IVTSSGDTTCALWDIETGQQTTTFTGHTG 185 +T N S E GH G ++ F DN+ +VTSS D T +WD+ + + H Sbjct: 61 RTTNPNPVASFE--GHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNA 117 Query: 186 DVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHE-SDINAICFFPNGNAFATG 244 V + + P+ +S D + ++WD+ E C T + + + ++ +G+ A Sbjct: 118 PVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAA 177 Query: 245 SDDATCRLFDLRADQELMTYSHDNIICG-------ITSVSFSKSGRLLLAGYDDFNCNVW 297 + C ++++ + SH + IT + S + L D VW Sbjct: 178 NTKGNCYVWEMPNHTDA---SHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVW 234 Query: 298 ---DALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 D K + L GH V + D + T S D ++++W+ Sbjct: 235 SIDDDFKLE--TTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWD 278 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 52/251 (20%), Positives = 102/251 (40%), Gaps = 28/251 (11%) Query: 34 TNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWD----SYTTNK 89 T N +PV + GH + ++ + D+R +V++S+DG + +WD S N Sbjct: 62 TTNPNPVA--------SFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY 113 Query: 90 VHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCC 149 H P+ + G ++C NI I++L + +++ E T S Sbjct: 114 KHNAPVNE----VVIHPNQGELISCDRDGNI-RIWDLGENQCTHQLTPE--DDTSLQSLS 166 Query: 150 RFLDDNQIVTSSGDTTCALWDIETG------QQTTTFTGHTGDVMSLSLAPDTRLFVSGA 203 D + + ++ C +W++ + T F H+ + + L+ D + + + Sbjct: 167 MASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCS 226 Query: 204 CDASAKLWDVREGM-CRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELM 262 D +A++W + + T GH+ + F + T S D RL+DL + + Sbjct: 227 ADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVR 286 Query: 263 TY--SHDNIIC 271 Y H +C Sbjct: 287 QYGGHHKGAVC 297 Score = 35.8 bits (81), Expect = 0.026, Method: Compositional matrix adjust. Identities = 28/136 (20%), Positives = 61/136 (44%), Gaps = 10/136 (7%) Query: 64 GTDSRLLVSASQDGKLIIWD-SYTTNKVHAIPL-----RSSWVMTCAYAPSGNYVACGGL 117 +D +L +A+ G +W+ T+ H P+ S+++ + ++A Sbjct: 168 ASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSA 227 Query: 118 DNICSIYNLKTREGNVRVSRELAGHTGYLSCCRF-LDDNQIVTSSGDTTCALWDIETGQQ 176 D+ ++++ + + ++ L GH ++ C F D +VT+S D LWD+ T + Sbjct: 228 DHTARVWSI---DDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREI 284 Query: 177 TTTFTGHTGDVMSLSL 192 + GH + ++L Sbjct: 285 VRQYGGHHKGAVCVAL 300 >5LCW-Q nrPDB Length = 374 Score = 73.9 bits (180), Expect = 8e-14, Method: Compositional matrix adjust. Identities = 65/285 (22%), Positives = 129/285 (45%), Gaps = 26/285 (9%) Query: 70 LVSASQDGKLIIWDSYTTNKVHAIPLRSS--WVMTCAYAPSGNYVACGGLDNICSIYNLK 127 +++ + D + +W + + + + + + ++ + A+ GNY+A G +++++ Sbjct: 72 VLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQ 131 Query: 128 TREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALW--DIETGQQ-TTTFTGHT 184 + + R + H+ + L N + SSG + + D+ + T +GH+ Sbjct: 132 QQ----KRLRNMTSHSARVGS---LSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHS 184 Query: 185 GDVMSLSLAPDTRLFVSGACDASAKLWDVREG----MCRQTFTGHESDINAICFFP-NGN 239 +V L APD R SG D +W G + QTFT H+ + A+ + P N Sbjct: 185 QEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSN 244 Query: 240 AFATG--SDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCN-- 295 ATG + D R++++ + L + +C S+ +S + L++G+ F N Sbjct: 245 VLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVC---SILWSPHYKELISGHG-FAQNQL 300 Query: 296 -VWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIW 339 +W + L GH +RV L ++ DG VA+ + D L++W Sbjct: 301 VIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 345 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 48/185 (25%), Positives = 75/185 (40%), Gaps = 25/185 (13%) Query: 42 RIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRS---- 97 R+ TL GH ++ + W D R L S D + +W S + +PL++ Sbjct: 171 RVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPS-APGEGGWVPLQTFTQH 229 Query: 98 -SWVMTCAYAP-SGNYVACGG--------LDNICSIYNLKTREGNVRVSREL-AGHTGYL 146 V A+ P N +A GG + N+CS L + + +V L + H L Sbjct: 230 QGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKEL 289 Query: 147 SCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDA 206 NQ+V +W T + GHT V+SL+++PD S A D Sbjct: 290 ISGHGFAQNQLV---------IWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADE 340 Query: 207 SAKLW 211 + +LW Sbjct: 341 TLRLW 345 >5G04-R nrPDB Length = 499 Score = 73.9 bits (180), Expect = 9e-14, Method: Compositional matrix adjust. Identities = 65/285 (22%), Positives = 131/285 (45%), Gaps = 26/285 (9%) Query: 70 LVSASQDGKLIIWDSYTTNKVHAIPLRSS--WVMTCAYAPSGNYVACGGLDNICSIYNLK 127 +++ + D + +W + + + + + + ++ + A+ GNY+A G +++++ Sbjct: 197 VLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQ 256 Query: 128 TREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALW--DIETGQQ-TTTFTGHT 184 ++ R+ R + H+ + + N + SSG + + D+ + T +GH+ Sbjct: 257 QQK---RL-RNMTSHSARVGSLSW---NSYILSSGSRSGHIHHHDVRVAEHHVATLSGHS 309 Query: 185 GDVMSLSLAPDTRLFVSGACDASAKLWDVREG----MCRQTFTGHESDINAICFFP-NGN 239 +V L APD R SG D +W G + QTFT H+ + A+ + P N Sbjct: 310 QEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSN 369 Query: 240 AFATG--SDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCN-- 295 ATG + D R++++ + L + +C S+ +S + L++G+ F N Sbjct: 370 VLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVC---SILWSPHYKELISGHG-FAQNQL 425 Query: 296 -VWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIW 339 +W + L GH +RV L ++ DG VA+ + D L++W Sbjct: 426 VIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 47/177 (26%), Positives = 73/177 (41%), Gaps = 25/177 (14%) Query: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRS-----SWVMTCA 104 TL GH ++ + W D R L S D + +W S + +PL++ V A Sbjct: 304 TLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPS-APGEGGWVPLQTFTQHQGAVKAVA 362 Query: 105 YAP-SGNYVACGG--------LDNICSIYNLKTREGNVRVSREL-AGHTGYLSCCRFLDD 154 + P N +A GG + N+CS L + + +V L + H L Sbjct: 363 WCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQ 422 Query: 155 NQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLW 211 NQ+V +W T + GHT V+SL+++PD S A D + +LW Sbjct: 423 NQLV---------IWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470 >4N14-A nrPDB Length = 314 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 65/285 (22%), Positives = 131/285 (45%), Gaps = 26/285 (9%) Query: 70 LVSASQDGKLIIWDSYTTNKVHAIPLRSS--WVMTCAYAPSGNYVACGGLDNICSIYNLK 127 +++ + D + +W + + + + + + ++ + A+ GNY+A G +++++ Sbjct: 34 VLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQ 93 Query: 128 TREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALW--DIETGQQ-TTTFTGHT 184 ++ R+ R + H+ + + N + SSG + + D+ + T +GH+ Sbjct: 94 QQK---RL-RNMTSHSARVGSLSW---NSYILSSGSRSGHIHHHDVRVAEHHVATLSGHS 146 Query: 185 GDVMSLSLAPDTRLFVSGACDASAKLWDVREG----MCRQTFTGHESDINAICFFP-NGN 239 +V L APD R SG D +W G + QTFT H+ + A+ + P N Sbjct: 147 QEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSN 206 Query: 240 AFATG--SDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCN-- 295 ATG + D R++++ + L + +C S+ +S + L++G+ F N Sbjct: 207 VLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVC---SILWSPHYKELISGHG-FAQNQL 262 Query: 296 -VWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIW 339 +W + L GH +RV L ++ DG VA+ + D L++W Sbjct: 263 VIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 307 Score = 52.8 bits (125), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 55/225 (24%), Positives = 91/225 (40%), Gaps = 32/225 (14%) Query: 9 QEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRR-------TLRGHLAKIYAM 61 Q+ ++L+N + + + + S I ++ G I R TL GH ++ + Sbjct: 93 QQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGL 152 Query: 62 HWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRS-----SWVMTCAYAP-SGNYVACG 115 W D R L S D + +W S + +PL++ V A+ P N +A G Sbjct: 153 RWAPDGRHLASGGNDNLVNVWPS-APGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATG 211 Query: 116 G--------LDNICSIYNLKTREGNVRVSREL-AGHTGYLSCCRFLDDNQIVTSSGDTTC 166 G + N+CS L + + +V L + H L NQ+V Sbjct: 212 GGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLV-------- 263 Query: 167 ALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLW 211 +W T + GHT V+SL+++PD S A D + +LW Sbjct: 264 -IWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 307 >3MKQ-A nrPDB Length = 814 Score = 72.4 bits (176), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 47/192 (24%), Positives = 85/192 (44%), Gaps = 12/192 (6%) Query: 70 LVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTR 129 ++ S D ++ +++ T KV ++ + A P+ YV G D ++N Sbjct: 70 IIVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWNW--- 126 Query: 130 EGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSG--DTTCALWDIETGQQTTTFTGHTGDV 187 E N + + GH ++ C F + +SG D T +W + GQ T FT TG Sbjct: 127 ENNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSL--GQSTPNFTLTTGQE 184 Query: 188 MSLSLA-----PDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFA 242 ++ PD ++ + D + K+WD + C T GH S+++ F P Sbjct: 185 RGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAVFHPTLPIII 244 Query: 243 TGSDDATCRLFD 254 +GS+D T ++++ Sbjct: 245 SGSEDGTLKIWN 256 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 55/263 (20%), Positives = 114/263 (43%), Gaps = 12/263 (4%) Query: 43 IQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMT 102 +++ ++T ++ + + +++ G++ IW+ T +V +I + + V Sbjct: 1 MKLDIKKTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVEIWNYETQVEVRSIQVTETPVRA 60 Query: 103 CAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYL-SCCRFLDDNQIVTSS 161 + N++ G D ++N T E V + H Y+ S +++ S Sbjct: 61 GKFIARKNWIIVGSDDFRIRVFNYNTGEKVV----DFEAHPDYIRSIAVHPTKPYVLSGS 116 Query: 162 GDTTCALWDIETG-QQTTTFTGHTGDVMSLSLAP-DTRLFVSGACDASAKLWDVREGMCR 219 D T LW+ E TF GH VM ++ P D F SG D + K+W + + Sbjct: 117 DDLTVKLWNWENNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPN 176 Query: 220 QTF-TGHESDINAICFF--PNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSV 276 T TG E +N + ++ P+ T SDD T +++D + + T + + ++ Sbjct: 177 FTLTTGQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATL--EGHMSNVSFA 234 Query: 277 SFSKSGRLLLAGYDDFNCNVWDA 299 F + ++++G +D +W++ Sbjct: 235 VFHPTLPIIISGSEDGTLKIWNS 257 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 61/248 (24%), Positives = 100/248 (40%), Gaps = 20/248 (8%) Query: 97 SSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQ 156 WV+T Y SG V + + +++ E VR + +A N Sbjct: 25 EPWVLTTLY--SGR-VEIWNYETQVEVRSIQVTETPVRAGKFIA------------RKNW 69 Query: 157 IVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREG 216 I+ S D +++ TG++ F H + S+++ P +SG+ D + KLW+ Sbjct: 70 IIVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWNWENN 129 Query: 217 -MCRQTFTGHESDINAICFFP-NGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGIT 274 QTF GHE + + F P + + FA+G D T +++ L T + G+ Sbjct: 130 WALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQ-ERGVN 188 Query: 275 SVSFS--KSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSW 332 V + ++ DD +WD L GH + VS + +GS Sbjct: 189 YVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAVFHPTLPIIISGSE 248 Query: 333 DSFLKIWN 340 D LKIWN Sbjct: 249 DGTLKIWN 256 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 38/157 (24%), Positives = 62/157 (39%), Gaps = 3/157 (1%) Query: 99 WVMTCAYAPS-GNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQI 157 +VM A+ P + A G LD +++L N ++ Y+ D + Sbjct: 142 FVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQERGVNYVDYYPLPDKPYM 201 Query: 158 VTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGM 217 +T+S D T +WD +T T GH +V P + +SG+ D + K+W+ Sbjct: 202 ITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAVFHPTLPIIISGSEDGTLKIWNSSTYK 261 Query: 218 CRQTFTGHESDINAICFFPNG--NAFATGSDDATCRL 252 +T I P G N A+G D+ L Sbjct: 262 VEKTLNVGLERSWCIATHPTGRKNYIASGFDNGFTVL 298 Score = 44.7 bits (104), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 35/168 (20%), Positives = 71/168 (42%), Gaps = 14/168 (8%) Query: 179 TFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNG 238 TF+ + V + P ++ ++W+ + ++ E+ + A F Sbjct: 8 TFSNRSDRVKGIDFHPTEPWVLTTLYSGRVEIWNYETQVEVRSIQVTETPVRAGKFIARK 67 Query: 239 NAFATGSDDATCRLFDLRADQELMTY-SHDNIICGITSVSFSKSGRLLLAGYDDFNCNVW 297 N GSDD R+F+ ++++ + +H + I S++ + +L+G DD +W Sbjct: 68 NWIIVGSDDFRIRVFNYNTGEKVVDFEAHPDY---IRSIAVHPTKPYVLSGSDDLTVKLW 124 Query: 298 D-----ALKADRAGVLAGHDNRVSCLGV-TDDGMAVATGSWDSFLKIW 339 + AL+ GH++ V C+ D A+G D +K+W Sbjct: 125 NWENNWALEQ----TFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVW 168 Score = 40.8 bits (94), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 25/83 (30%), Positives = 40/83 (48%), Gaps = 3/83 (3%) Query: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDS--YTTNKVHAIPLRSSWVMTCAYAP 107 TL GH++ + + +++S S+DG L IW+S Y K + L SW + Sbjct: 223 TLEGHMSNVSFAVFHPTLPIIISGSEDGTLKIWNSSTYKVEKTLNVGLERSWCIATHPTG 282 Query: 108 SGNYVACGGLDNICSIYNLKTRE 130 NY+A G DN ++ +L E Sbjct: 283 RKNYIAS-GFDNGFTVLSLGNDE 304 >2YNP-A nrPDB Length = 604 Score = 72.0 bits (175), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 47/192 (24%), Positives = 85/192 (44%), Gaps = 12/192 (6%) Query: 70 LVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTR 129 ++ S D ++ +++ T KV ++ + A P+ YV G D ++N Sbjct: 70 IIVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWNW--- 126 Query: 130 EGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSG--DTTCALWDIETGQQTTTFTGHTGDV 187 E N + + GH ++ C F + +SG D T +W + GQ T FT TG Sbjct: 127 ENNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSL--GQSTPNFTLTTGQE 184 Query: 188 MSLSLA-----PDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFA 242 ++ PD ++ + D + K+WD + C T GH S+++ F P Sbjct: 185 RGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAVFHPTLPIII 244 Query: 243 TGSDDATCRLFD 254 +GS+D T ++++ Sbjct: 245 SGSEDGTLKIWN 256 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 61/248 (24%), Positives = 100/248 (40%), Gaps = 20/248 (8%) Query: 97 SSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQ 156 WV+T Y SG V + + +++ E VR + +A N Sbjct: 25 EPWVLTTLY--SGR-VELWNYETQVEVRSIQVTETPVRAGKFIA------------RKNW 69 Query: 157 IVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREG 216 I+ S D +++ TG++ F H + S+++ P +SG+ D + KLW+ Sbjct: 70 IIVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWNWENN 129 Query: 217 MC-RQTFTGHESDINAICFFP-NGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGIT 274 QTF GHE + + F P + + FA+G D T +++ L T + G+ Sbjct: 130 WALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQ-ERGVN 188 Query: 275 SVSFS--KSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSW 332 V + ++ DD +WD L GH + VS + +GS Sbjct: 189 YVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAVFHPTLPIIISGSE 248 Query: 333 DSFLKIWN 340 D LKIWN Sbjct: 249 DGTLKIWN 256 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 54/263 (20%), Positives = 114/263 (43%), Gaps = 12/263 (4%) Query: 43 IQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMT 102 +++ ++T ++ + + +++ G++ +W+ T +V +I + + V Sbjct: 1 MKLDIKKTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVELWNYETQVEVRSIQVTETPVRA 60 Query: 103 CAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYL-SCCRFLDDNQIVTSS 161 + N++ G D ++N T E V + H Y+ S +++ S Sbjct: 61 GKFIARKNWIIVGSDDFRIRVFNYNTGEKVV----DFEAHPDYIRSIAVHPTKPYVLSGS 116 Query: 162 GDTTCALWDIETG-QQTTTFTGHTGDVMSLSLAP-DTRLFVSGACDASAKLWDVREGMCR 219 D T LW+ E TF GH VM ++ P D F SG D + K+W + + Sbjct: 117 DDLTVKLWNWENNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPN 176 Query: 220 QTF-TGHESDINAICFF--PNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSV 276 T TG E +N + ++ P+ T SDD T +++D + + T + + ++ Sbjct: 177 FTLTTGQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATL--EGHMSNVSFA 234 Query: 277 SFSKSGRLLLAGYDDFNCNVWDA 299 F + ++++G +D +W++ Sbjct: 235 VFHPTLPIIISGSEDGTLKIWNS 257 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 38/157 (24%), Positives = 62/157 (39%), Gaps = 3/157 (1%) Query: 99 WVMTCAYAPS-GNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQI 157 +VM A+ P + A G LD +++L N ++ Y+ D + Sbjct: 142 FVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQERGVNYVDYYPLPDKPYM 201 Query: 158 VTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGM 217 +T+S D T +WD +T T GH +V P + +SG+ D + K+W+ Sbjct: 202 ITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAVFHPTLPIIISGSEDGTLKIWNSSTYK 261 Query: 218 CRQTFTGHESDINAICFFPNG--NAFATGSDDATCRL 252 +T I P G N A+G D+ L Sbjct: 262 VEKTLNVGLERSWCIATHPTGRKNYIASGFDNGFTVL 298 Score = 45.8 bits (107), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 36/169 (21%), Positives = 72/169 (42%), Gaps = 14/169 (8%) Query: 179 TFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNG 238 TF+ + V + P ++ +LW+ + ++ E+ + A F Sbjct: 8 TFSNRSDRVKGIDFHPTEPWVLTTLYSGRVELWNYETQVEVRSIQVTETPVRAGKFIARK 67 Query: 239 NAFATGSDDATCRLFDLRADQELMTY-SHDNIICGITSVSFSKSGRLLLAGYDDFNCNVW 297 N GSDD R+F+ ++++ + +H + I S++ + +L+G DD +W Sbjct: 68 NWIIVGSDDFRIRVFNYNTGEKVVDFEAHPDY---IRSIAVHPTKPYVLSGSDDLTVKLW 124 Query: 298 D-----ALKADRAGVLAGHDNRVSCLGV-TDDGMAVATGSWDSFLKIWN 340 + AL+ GH++ V C+ D A+G D +K+W+ Sbjct: 125 NWENNWALEQ----TFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWS 169 Score = 40.0 bits (92), Expect = 0.001, Method: Compositional matrix adjust. Identities = 25/83 (30%), Positives = 40/83 (48%), Gaps = 3/83 (3%) Query: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDS--YTTNKVHAIPLRSSWVMTCAYAP 107 TL GH++ + + +++S S+DG L IW+S Y K + L SW + Sbjct: 223 TLEGHMSNVSFAVFHPTLPIIISGSEDGTLKIWNSSTYKVEKTLNVGLERSWCIATHPTG 282 Query: 108 SGNYVACGGLDNICSIYNLKTRE 130 NY+A G DN ++ +L E Sbjct: 283 RKNYIAS-GFDNGFTVLSLGNDE 304 >5L9T-R nrPDB Length = 493 Score = 71.6 bits (174), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 64/248 (25%), Positives = 104/248 (41%), Gaps = 15/248 (6%) Query: 100 VMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVT 159 V + ++ GN VA G I++ + ++S L GHT + + + Q+ + Sbjct: 232 VTSVGWSERGNLVAVGTHKGFVQIWDAAAGK---KLSM-LEGHTARVGALAW-NAEQLSS 286 Query: 160 SSGDTTCALWDIETG--QQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGM 217 S D DI T Q GH +V L + D +L SG D +W+ Sbjct: 287 GSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLS 346 Query: 218 CRQTFTGHESDINAICFFPNGN---AFATGSDDATCRLFDLRADQELMTYSHDNIICGIT 274 Q +T H + + AI + P+ + A G+ D R ++ Q L + +C + Sbjct: 347 PVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNL- 405 Query: 275 SVSFSKSGRLLLA--GYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSW 332 ++SK L++ GY VW + L GH RV L ++ DG A+ TG+ Sbjct: 406 --AWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAG 463 Query: 333 DSFLKIWN 340 D L+ WN Sbjct: 464 DETLRFWN 471 Score = 65.1 bits (157), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 45/179 (25%), Positives = 80/179 (44%), Gaps = 19/179 (10%) Query: 45 MRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCA 104 +++ R L+GH ++ + W TD +LL S D KL++W+ + + V + V A Sbjct: 303 LQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIA 362 Query: 105 YAPSGN-YVACGG--LDNICSIYNLKTRE-------GNVRVSRELAGHTGYLSCCRFLDD 154 ++P + +A GG D +N T + G+ + + H L Sbjct: 363 WSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQ 422 Query: 155 NQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDV 213 NQI+ +W + Q TGH+ V+ L+++PD V+GA D + + W+V Sbjct: 423 NQIL---------VWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNV 472 >4J0W-A nrPDB Length = 343 Score = 70.9 bits (172), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 73/306 (23%), Positives = 119/306 (38%), Gaps = 55/306 (17%) Query: 49 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPS 108 R LRGH I + D + SA++D +I W + K+H IP Sbjct: 8 RVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAK----------- 56 Query: 109 GNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTT--C 166 K EG + GH+ ++ C D + + +SGD + Sbjct: 57 ------------------KGAEG------KPPGHSSHVLCMAISSDGKYL-ASGDRSKLI 91 Query: 167 ALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHE 226 +W+ ++ Q TFTGH V L+ T S + D S K+W+V E +T GH+ Sbjct: 92 LIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQ 151 Query: 227 SDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLL 286 + A+ G D T R++ + + +L+ Y H I I ++ ++ Sbjct: 152 DAVAALDALSRECCVTAGGRDGTVRVWKIPEESQLVFYGHQGSIDCIHLINEEH----MV 207 Query: 287 AGYDDFNCNVWDALKADRAGVL--AGHDNR----------VSCLGVTDDGMAVATGSWDS 334 +G DD + +W L R L H R +S + + VATGS S Sbjct: 208 SGADDGSVALW-GLSKKRPLALQREAHGLRGEPGLEQPFWISSVAALLNTDLVATGSHSS 266 Query: 335 FLKIWN 340 +++W Sbjct: 267 CVRLWQ 272 >3FM0-A nrPDB Length = 345 Score = 70.9 bits (172), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 54/208 (25%), Positives = 92/208 (44%), Gaps = 13/208 (6%) Query: 56 AKIYAMHWGTDSRLLVSASQDGKLIIW----DSYTTNKVHAIPLRSSWVMTCAYAPSGNY 111 ++ + + W LL S D ++ IW DS+ V + + + V A++P GNY Sbjct: 17 SRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRT-VRKVAWSPCGNY 75 Query: 112 VACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDD-NQIVTSSGDTTCALWD 170 +A D I+ K + + L GH + + N + T S D + +W+ Sbjct: 76 LASASFDATTCIW--KKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWE 133 Query: 171 IETGQQ---TTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREG--MCRQTFTGH 225 ++ + + HT DV + P L S + D + KL+ E +C T GH Sbjct: 134 VDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGH 193 Query: 226 ESDINAICFFPNGNAFATGSDDATCRLF 253 ES + ++ F P+G A+ SDD T R++ Sbjct: 194 ESTVWSLAFDPSGQRLASCSDDRTVRIW 221 Score = 64.7 bits (156), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 59/245 (24%), Positives = 103/245 (42%), Gaps = 32/245 (13%) Query: 89 KVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLK---------TREGNVRVSREL 139 +V A P W + A+ P+G +A G D I+ + EG+ R R++ Sbjct: 10 RVPAHPDSRCWFL--AWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKV 67 Query: 140 AGHTGYLSCCRFLDDNQIVTSSGDTTCALW--DIETGQQTTTFTGHTGDVMSLSLAPDTR 197 A + C N + ++S D T +W + + + TT GH +V S++ AP Sbjct: 68 A----WSPC-----GNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGN 118 Query: 198 LFVSGACDASAKLWDVREG---MCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFD 254 L + + D S +W+V E C H D+ + + P+ A+ S D T +L+ Sbjct: 119 LLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYR 178 Query: 255 LRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNR 314 D + + + + S++F SG+ L + DD +W L G++ Sbjct: 179 EEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQY-------LPGNEQG 231 Query: 315 VSCLG 319 V+C G Sbjct: 232 VACSG 236 Score = 50.8 bits (120), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 48/208 (23%), Positives = 88/208 (42%), Gaps = 22/208 (10%) Query: 149 CRFLDDNQ----IVTSSGDTTCALWDIETGQ---QTTTFTGHTGDVMSLSLAPDTRLFVS 201 C FL N + + GD +W E ++ GH V ++ +P S Sbjct: 19 CWFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLAS 78 Query: 202 GACDASAKLWDVREG--MCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQ 259 + DA+ +W + C T GHE+++ ++ + P+GN AT S D + ++++ + Sbjct: 79 ASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEED 138 Query: 260 E------LMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRA--GVLAGH 311 E L +++ D + V + S LL + D ++ + D L GH Sbjct: 139 EYECVSVLNSHTQD-----VKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGH 193 Query: 312 DNRVSCLGVTDDGMAVATGSWDSFLKIW 339 ++ V L G +A+ S D ++IW Sbjct: 194 ESTVWSLAFDPSGQRLASCSDDRTVRIW 221 Score = 36.6 bits (83), Expect = 0.017, Method: Compositional matrix adjust. Identities = 59/272 (21%), Positives = 93/272 (34%), Gaps = 63/272 (23%) Query: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSW---VMTCAYA 106 TL GH ++ ++ W LL + S+D + +W+ ++ + + +S V + Sbjct: 100 TLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWH 159 Query: 107 PSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQ-IVTSSGDTT 165 PS +A D+ +Y + E + L GH + F Q + + S D T Sbjct: 160 PSQELLASASYDDTVKLY--REEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRT 217 Query: 166 CALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSG-----ACDASAKLWDVREGMCRQ 220 +W R ++ G AC S W C Sbjct: 218 VRIW---------------------------RQYLPGNEQGVACSGSDPSW-----KCIC 245 Query: 221 TFTG-HESDINAICFFPNGNAFATGSDDATCRLF--DLRADQELMTYSHDNIICGITSVS 277 T +G H I I + A AT D R+F D +D + T Sbjct: 246 TLSGFHSRTIYDIAWCQLTGALATACGDDAIRVFQEDPNSDPQQPT-------------- 291 Query: 278 FSKSGRLLLAGYDDFNCNVWDALKADRAGVLA 309 FS + L A D NC W+ G+LA Sbjct: 292 FSLTAHLHQAHSQDVNCVAWN---PKEPGLLA 320 >4AEZ-A nrPDB Length = 401 Score = 69.3 bits (168), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 60/254 (23%), Positives = 117/254 (46%), Gaps = 20/254 (7%) Query: 96 RSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDN 155 S++V + ++ G++++ G + + IY+++++ R +AGH + C + N Sbjct: 133 ESTYVASVKWSHDGSFLSVGLGNGLVDIYDVESQTK----LRTMAGHQARVGCLSW---N 185 Query: 156 QIVTSSGDTTCALW--DIETG-QQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWD 212 + V SSG + A+ D+ Q T GH+ +V L+ D SG D ++WD Sbjct: 186 RHVLSSGSRSGAIHHHDVRIANHQIGTLQGHSSEVCGLAWRSDGLQLASGGNDNVVQIWD 245 Query: 213 VREGMCRQTFTGHESDINAICFFP-NGNAFAT--GSDDATCRLFDLRADQELMTYSHDNI 269 R + + T T H + + A+ + P N AT G+ D ++ + T + Sbjct: 246 ARSSIPKFTKTNHNAAVKAVAWCPWQSNLLATGGGTMDKQIHFWNAATGARVNTV---DA 302 Query: 270 ICGITSVSFSKSGRLLLA--GYDDFNCNVWDALKA--DRAGVLAGHDNRVSCLGVTDDGM 325 +TS+ +S + +++ G+ D N ++W + + + HD RV ++ DG Sbjct: 303 GSQVTSLIWSPHSKEIMSTHGFPDNNLSIWSYSSSGLTKQVDIPAHDTRVLYSALSPDGR 362 Query: 326 AVATGSWDSFLKIW 339 ++T + D LK W Sbjct: 363 ILSTAASDENLKFW 376 Score = 48.1 bits (113), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 46/182 (25%), Positives = 78/182 (42%), Gaps = 11/182 (6%) Query: 42 RIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVM 101 RI TL+GH +++ + W +D L S D + IWD+ ++ ++ V Sbjct: 204 RIANHQIGTLQGHSSEVCGLAWRSDGLQLASGGNDNVVQIWDARSSIPKFTKTNHNAAVK 263 Query: 102 TCAYAP-SGNYVACGG--LDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIV 158 A+ P N +A GG +D +N T RV+ AG + S +I+ Sbjct: 264 AVAWCPWQSNLLATGGGTMDKQIHFWNAAT---GARVNTVDAG-SQVTSLIWSPHSKEIM 319 Query: 159 TSSG--DTTCALWDIETGQQTTT--FTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVR 214 ++ G D ++W + T H V+ +L+PD R+ + A D + K W V Sbjct: 320 STHGFPDNNLSIWSYSSSGLTKQVDIPAHDTRVLYSALSPDGRILSTAASDENLKFWRVY 379 Query: 215 EG 216 +G Sbjct: 380 DG 381 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 49/219 (22%), Positives = 92/219 (42%), Gaps = 13/219 (5%) Query: 43 IQMRTR-RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTN-KVHAIPLRSSWV 100 ++ +T+ RT+ GH A++ + W + +L S S+ G + D N ++ + SS V Sbjct: 163 VESQTKLRTMAGHQARVGCLSW--NRHVLSSGSRSGAIHHHDVRIANHQIGTLQGHSSEV 220 Query: 101 MTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTS 160 A+ G +A GG DN+ I++ ++ + A C N + T Sbjct: 221 CGLAWRSDGLQLASGGNDNVVQIWDARSSIPKFTKTNHNAAVKAVAWCP--WQSNLLATG 278 Query: 161 SG--DTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVS--GACDASAKLWDV-RE 215 G D W+ TG + T + V SL +P ++ +S G D + +W Sbjct: 279 GGTMDKQIHFWNAATGARVNTVDAGS-QVTSLIWSPHSKEIMSTHGFPDNNLSIWSYSSS 337 Query: 216 GMCRQT-FTGHESDINAICFFPNGNAFATGSDDATCRLF 253 G+ +Q H++ + P+G +T + D + + Sbjct: 338 GLTKQVDIPAHDTRVLYSALSPDGRILSTAASDENLKFW 376 Score = 29.3 bits (64), Expect = 2.5, Method: Compositional matrix adjust. Identities = 13/35 (37%), Positives = 21/35 (60%) Query: 306 GVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 G L GH + V L DG+ +A+G D+ ++IW+ Sbjct: 211 GTLQGHSSEVCGLAWRSDGLQLASGGNDNVVQIWD 245 >4BTS-AR nrPDB Length = 343 Score = 68.6 bits (166), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 48/204 (23%), Positives = 91/204 (44%), Gaps = 16/204 (7%) Query: 153 DDNQIVTSSGDTTCALWDIETGQQTTTF-------TGHTGDVMSLSLAPDTRLFVSGACD 205 D +++ S D T +W + +Q F TGH V L+L+ + +S + D Sbjct: 38 DSPVLISGSRDKTVMIWKLYEEEQNGYFGIPHKALTGHNHFVSDLALSQENCFAISSSWD 97 Query: 206 ASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYS 265 + +LWD+R G + F GH+S++ ++ F P+ + + +L+++ + + + Sbjct: 98 KTLRLWDLRTGTTYKRFVGHQSEVYSVAFSPDNRQILSAGAEREIKLWNILGECKFSSAE 157 Query: 266 HDNIICGITSVSFS---KSGRLLLAGYDDFNCNVWDA-LKADRAGV-----LAGHDNRVS 316 +N ++ V +S KS + F WD LK H++ V+ Sbjct: 158 KENHSDWVSCVRYSPIMKSANKVQPFAPYFASVGWDGRLKVWNTNFQIRYTFKAHESNVN 217 Query: 317 CLGVTDDGMAVATGSWDSFLKIWN 340 L ++ +G +ATG D L IW+ Sbjct: 218 HLSISPNGKYIATGGKDKKLLIWD 241 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 69/330 (20%), Positives = 112/330 (33%), Gaps = 112/330 (33%) Query: 43 IQMRTRRTLRGH------LAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTT--NKVHAIP 94 IQ+ R L GH + ++ DS +L+S S+D ++IW Y N IP Sbjct: 9 IQVVKRGILEGHSDWVTSIVAGFSQKENEDSPVLISGSRDKTVMIWKLYEEEQNGYFGIP 68 Query: 95 LRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDD 154 ++ L GH ++S + Sbjct: 69 HKA-----------------------------------------LTGHNHFVSDLALSQE 87 Query: 155 NQI-VTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDV 213 N ++SS D T LWD+ TG F GH +V S++ +PD R +S + KLW++ Sbjct: 88 NCFAISSSWDKTLRLWDLRTGTTYKRFVGHQSEVYSVAFSPDNRQILSAGAEREIKLWNI 147 Query: 214 REGMCR----------------------------QTFT---------------------- 223 G C+ Q F Sbjct: 148 L-GECKFSSAEKENHSDWVSCVRYSPIMKSANKVQPFAPYFASVGWDGRLKVWNTNFQIR 206 Query: 224 ----GHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICG--ITSVS 277 HES++N + PNG ATG D ++D+ +TY G I ++ Sbjct: 207 YTFKAHESNVNHLSISPNGKYIATGGKDKKLLIWDILN----LTYPQREFDAGSTINQIA 262 Query: 278 FSKSGRLLLAGYDDFNCNVWDALKADRAGV 307 F+ + + G D +++ + +A V Sbjct: 263 FNPKLQWVAVGTDQ-GVKIFNLMTQSKAPV 291 Score = 58.9 bits (141), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 61/268 (22%), Positives = 106/268 (39%), Gaps = 30/268 (11%) Query: 48 RRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAP 107 + L GH + + ++ +S+S D L +WD T S V + A++P Sbjct: 69 HKALTGHNHFVSDLALSQENCFAISSSWDKTLRLWDLRTGTTYKRFVGHQSEVYSVAFSP 128 Query: 108 SGNYVACGGLDNICSIYNLKTREGNVRVSR-ELAGHTGYLSCCRF----LDDNQIVTSSG 162 + G + ++N+ G + S E H+ ++SC R+ N++ + Sbjct: 129 DNRQILSAGAEREIKLWNIL---GECKFSSAEKENHSDWVSCVRYSPIMKSANKVQPFAP 185 Query: 163 DTTCALWDIETG------QQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREG 216 WD Q TF H +V LS++P+ + +G D +WD+ Sbjct: 186 YFASVGWDGRLKVWNTNFQIRYTFKAHESNVNHLSISPNGKYIATGGKDKKLLIWDILNL 245 Query: 217 MCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRA---------DQELMTYSH- 266 Q S IN I F P A G+D ++F+L + E +T + Sbjct: 246 TYPQREFDAGSTINQIAFNPKLQWVAVGTDQG-VKIFNLMTQSKAPVCTIEAEPITKAEG 304 Query: 267 ---DNIICGITSVSFSKSGRLLLAGYDD 291 N C TS++++ G+ L AG+ D Sbjct: 305 QKGKNPQC--TSLAWNALGKKLFAGFTD 330 >6Q8F-A nrPDB Length = 514 Score = 68.2 bits (165), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 64/317 (20%), Positives = 129/317 (40%), Gaps = 33/317 (10%) Query: 47 TRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHA---------IPLRS 97 +R G + + + D + LV+ S DG + +W+ +TT K+ + Sbjct: 207 SRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWN-FTTGKIRKDLKYQAQDNFMMMD 265 Query: 98 SWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRF-LDDNQ 156 V+ ++ +A G D ++ +++ + R R H+ ++C F D +Q Sbjct: 266 DAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFER---AHSKGVTCLSFSKDSSQ 322 Query: 157 IVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREG 216 I+++S D T + +++G+ F GH+ V + D +S + D + K+W+++ Sbjct: 323 ILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTT 382 Query: 217 MCRQTF------TGHESDINAICFFP-NGNAFATGSDDATCRLFDLRADQELMTYSH--- 266 C TF G + +N++ P N F + T + +++ Q + ++S Sbjct: 383 ECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQG-QIVRSFSSGKR 441 Query: 267 ---DNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDD 323 D + C + S G + +DF + + L H+ V + Sbjct: 442 EGGDFVCCAL-----SPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPH 496 Query: 324 GMAVATGSWDSFLKIWN 340 +AT S D LK+W Sbjct: 497 QNLIATYSEDGLLKLWK 513 Score = 39.3 bits (90), Expect = 0.002, Method: Compositional matrix adjust. Identities = 42/186 (22%), Positives = 64/186 (34%), Gaps = 34/186 (18%) Query: 46 RTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTT------------------ 87 +T + RGH + + + D ++SAS DG + IW+ TT Sbjct: 341 KTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDIT 400 Query: 88 -NKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYL 146 N V +P + C S V I ++ REG G Sbjct: 401 VNSVILLPKNPEHFVVCNR--SNTVVIMNMQGQIVRSFSSGKREG------------GDF 446 Query: 147 SCCRFLDDNQIVTSSG-DTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACD 205 CC + + G D + TG+ T T H DV+ ++ P L + + D Sbjct: 447 VCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSED 506 Query: 206 ASAKLW 211 KLW Sbjct: 507 GLLKLW 512 >5WYJ-BC nrPDB Length = 817 Score = 66.6 bits (161), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 50/185 (27%), Positives = 79/185 (42%), Gaps = 15/185 (8%) Query: 72 SASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREG 131 +AS D ++I YT HA + + +P+ + A D C I+NL+ E Sbjct: 472 TASMDVQIIKVSEYTR---HA---HEKDINALSVSPNDSIFATASYDKTCKIWNLENGE- 524 Query: 132 NVRVSRELAGHTGYL---SCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVM 188 + LA H L S C++ D + TSSGD T +W ++T T GHT V Sbjct: 525 ---LEATLANHKRGLWDVSFCQY--DKLLATSSGDKTVKIWSLDTFSVMKTLEGHTNAVQ 579 Query: 189 SLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDA 248 S + +S D K+WD G C +T GH + + A+ +G+ + D Sbjct: 580 RCSFINKQKQLISCGADGLIKIWDCSSGECLKTLDGHNNRLWALSTMNDGDMIVSADADG 639 Query: 249 TCRLF 253 + + Sbjct: 640 VFQFW 644 Score = 63.9 bits (154), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 51/248 (20%), Positives = 98/248 (39%), Gaps = 20/248 (8%) Query: 109 GNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLD------DNQIVTSSG 162 G ++A DN ++ + + GH+ ++ + ++T+S Sbjct: 400 GLWIATASKDNTAIVWRYNENSCKFDIYAKYIGHSAAVTAVGLPNIVSKGYPEFLLTASN 459 Query: 163 DTTCALWDIETGQ--------QTTTFT--GHTGDVMSLSLAPDTRLFVSGACDASAKLWD 212 D T W I + + +T H D+ +LS++P+ +F + + D + K+W+ Sbjct: 460 DLTIKKWIIPKPTASMDVQIIKVSEYTRHAHEKDINALSVSPNDSIFATASYDKTCKIWN 519 Query: 213 VREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYS-HDNIIC 271 + G T H+ + + F AT S D T +++ L + T H N Sbjct: 520 LENGELEATLANHKRGLWDVSFCQYDKLLATSSGDKTVKIWSLDTFSVMKTLEGHTN--- 576 Query: 272 GITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGS 331 + SF + L++ D +WD + L GH+NR+ L +DG + + Sbjct: 577 AVQRCSFINKQKQLISCGADGLIKIWDCSSGECLKTLDGHNNRLWALSTMNDGDMIVSAD 636 Query: 332 WDSFLKIW 339 D + W Sbjct: 637 ADGVFQFW 644 Score = 61.2 bits (147), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 60/245 (24%), Positives = 100/245 (40%), Gaps = 29/245 (11%) Query: 120 ICSIYNLKTREGNVRVSREL-AGHTGYLSCCRFLDDNQ-IVTSSGDTTCALWDIETGQ-- 175 I + +L E ++ + E+ GH L+ +D I T+S D T +W Sbjct: 364 IIPVPDLSGPEASLPLDVEIYEGHEDLLNSLDATEDGLWIATASKDNTAIVWRYNENSCK 423 Query: 176 --QTTTFTGHTGDVMSLSLAPD------TRLFVSGACDASAKLWDVREG----------M 217 + GH+ V ++ L P+ ++ + D + K W + + + Sbjct: 424 FDIYAKYIGHSAAVTAVGL-PNIVSKGYPEFLLTASNDLTIKKWIIPKPTASMDVQIIKV 482 Query: 218 CRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLR-ADQELMTYSHDNIICGITSV 276 T HE DINA+ PN + FAT S D TC++++L + E +H G+ V Sbjct: 483 SEYTRHAHEKDINALSVSPNDSIFATASYDKTCKIWNLENGELEATLANHKR---GLWDV 539 Query: 277 SFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVS-CLGVTDDGMAVATGSWDSF 335 SF + +LL D +W L GH N V C + ++ G+ D Sbjct: 540 SFCQYDKLLATSSGDKTVKIWSLDTFSVMKTLEGHTNAVQRCSFINKQKQLISCGA-DGL 598 Query: 336 LKIWN 340 +KIW+ Sbjct: 599 IKIWD 603 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 41/161 (25%), Positives = 64/161 (39%), Gaps = 19/161 (11%) Query: 100 VMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVT 159 + P G Y+ + I++LKT G V S +++ + L D + Sbjct: 64 ITALKLTPDGQYLTYVSQAQLLKIFHLKT--GKVVRSMKISSPSYILDA----DSTSTLL 117 Query: 160 SSG--DTTCALWDIETGQQTTTFTGHTGDVMSLS----LAPDTRLFVSGACDASAKLWDV 213 + G D + + DIE G T +F GH G + SL L L SG + K+WD+ Sbjct: 118 AVGGTDGSIIVVDIENGYITHSFKGHGGTISSLKFYGQLNSKIWLLASGDTNGMVKVWDL 177 Query: 214 REGMCRQTFTGHESDINAICFF-------PNGNAFATGSDD 247 + C T H S + + P+ N + G DD Sbjct: 178 VKRKCLHTLQEHTSAVRGLDIIEVPDNDEPSLNLLSGGRDD 218 Score = 42.0 bits (97), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 47/247 (19%), Positives = 98/247 (39%), Gaps = 35/247 (14%) Query: 125 NLKTREGNVRVSRELAGHTGYLSCCRFL--DDNQIVTSSGDTTCALWDIE--TGQQTT-- 178 +LK E ++V+ +AG+ G ++ R++ + N++ ++ + + + +G + + Sbjct: 319 DLKNDEDTIQVTSSIAGNHGIIADMRYVGPELNKLALATNSPSLRIIPVPDLSGPEASLP 378 Query: 179 ----TFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCR----QTFTGHESDIN 230 + GH + SL D + + D +A +W E C+ + GH + + Sbjct: 379 LDVEIYEGHEDLLNSLDATEDGLWIATASKDNTAIVWRYNENSCKFDIYAKYIGHSAAVT 438 Query: 231 AICFFPN------GNAFATGSDDATCRLFDLRAD-----------QELMTYSHDNIICGI 273 A+ PN T S+D T + + + E ++H+ I Sbjct: 439 AVGL-PNIVSKGYPEFLLTASNDLTIKKWIIPKPTASMDVQIIKVSEYTRHAHEK---DI 494 Query: 274 TSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWD 333 ++S S + + D C +W+ + LA H + + +AT S D Sbjct: 495 NALSVSPNDSIFATASYDKTCKIWNLENGELEATLANHKRGLWDVSFCQYDKLLATSSGD 554 Query: 334 SFLKIWN 340 +KIW+ Sbjct: 555 KTVKIWS 561 Score = 30.0 bits (66), Expect = 1.4, Method: Compositional matrix adjust. Identities = 33/165 (20%), Positives = 58/165 (35%), Gaps = 51/165 (30%) Query: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIW--DSYTTNKVHAIPLRSSWVMTCAYAP 107 TL H ++ + + +LL ++S D + IW D+++ Sbjct: 528 TLANHKRGLWDVSFCQYDKLLATSSGDKTVKIWSLDTFSV-------------------- 567 Query: 108 SGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLD-DNQIVTSSGDTTC 166 +KT EG HT + C F++ Q+++ D Sbjct: 568 ------------------MKTLEG----------HTNAVQRCSFINKQKQLISCGADGLI 599 Query: 167 ALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLW 211 +WD +G+ T GH + +LS D + VS D + W Sbjct: 600 KIWDCSSGECLKTLDGHNNRLWALSTMNDGDMIVSADADGVFQFW 644 >6BX3-A nrPDB Length = 314 Score = 65.5 bits (158), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 61/209 (29%), Positives = 94/209 (44%), Gaps = 16/209 (7%) Query: 102 TCA-YAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELA-GHTGYLS-CCRFLDDNQIV 158 TCA +P G ++A NI IY++ R VS+ L H S C D I Sbjct: 16 TCAKISPDGQFLAITQGLNIL-IYDINRRT----VSQTLVTSHARPFSELCWSPDGQCIA 70 Query: 159 TSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMC 218 T+S D + + + G TF GHT V+SL+ L + + D S K+WD G Sbjct: 71 TASDDFSVEIIHLSYGL-LHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSL 129 Query: 219 RQTFTGH-ESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHD------NIIC 271 +T + H E+ ++ + + ++GS D R+FD L T ++D N + Sbjct: 130 MKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVV 189 Query: 272 GITSVSFSKSGRLLLAGYDDFNCNVWDAL 300 I+ V FS++ R LL D +WD + Sbjct: 190 PISQVKFSENARYLLVKSLDGVVKIWDCI 218 Score = 29.3 bits (64), Expect = 2.9, Method: Compositional matrix adjust. Identities = 18/81 (22%), Positives = 38/81 (46%), Gaps = 1/81 (1%) Query: 49 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPS 108 T GH A + ++ + LL ++S D + IWD+ + + I S V++ + Sbjct: 89 HTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMN 148 Query: 109 -GNYVACGGLDNICSIYNLKT 128 + ++ G D + I++ +T Sbjct: 149 DSSILSSGSYDGLIRIFDAET 169 >5A31-R nrPDB Length = 386 Score = 65.1 bits (157), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 57/245 (23%), Positives = 109/245 (44%), Gaps = 16/245 (6%) Query: 102 TCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTS- 160 + ++ +G+++A G + + IY++ R + R L+GH ++C + +N ++TS Sbjct: 136 SLSWIGAGSHLAVGQANGLVEIYDVMKR----KCIRTLSGHIDRVACLSW--NNHVLTSG 189 Query: 161 SGDTTCALWDIETGQQT-TTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCR 219 S D D+ T HT +V L SG D +++ Sbjct: 190 SRDHRILHRDVRMPDPFFETIESHTQEVCGLKWNVADNKLASGGNDNVVHVYEGTSKSPI 249 Query: 220 QTFTGHESDINAICFFPNGN---AFATGSDDATCRLFDLRADQELMTYSHDNIICGITSV 276 TF H++ + A+ + P+ A G+ D +++++ ++ + IC + Sbjct: 250 LTFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDIDSGSQICNMV-- 307 Query: 277 SFSKSGRLLLA--GYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDS 334 +SK+ L+ GY +N +WD D +L GH RV L +++DG V +G+ D Sbjct: 308 -WSKNTNELVTSHGYSKYNLTLWDCNSMDPIAILKGHSFRVLHLTLSNDGTTVVSGAGDE 366 Query: 335 FLKIW 339 L+ W Sbjct: 367 TLRYW 371 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 42/183 (22%), Positives = 77/183 (42%), Gaps = 15/183 (8%) Query: 49 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPS 108 T+ H ++ + W L S D + +++ + + + + V A++P Sbjct: 208 ETIESHTQEVCGLKWNVADNKLASGGNDNVVHVYEGTSKSPILTFDEHKAAVKAMAWSPH 267 Query: 109 GNYV-ACGG--LDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFL---DDNQIVTSSG 162 V A GG D I+N+ T ++++S +G C + + N++VTS G Sbjct: 268 KRGVLATGGGTADRRLKIWNVNT---SIKMSDIDSGS----QICNMVWSKNTNELVTSHG 320 Query: 163 DT--TCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQ 220 + LWD + GH+ V+ L+L+ D VSGA D + + W + + Sbjct: 321 YSKYNLTLWDCNSMDPIAILKGHSFRVLHLTLSNDGTTVVSGAGDETLRYWKLFDVSVLN 380 Query: 221 TFT 223 FT Sbjct: 381 LFT 383 >4BH6-A nrPDB Length = 308 Score = 64.7 bits (156), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 57/245 (23%), Positives = 109/245 (44%), Gaps = 16/245 (6%) Query: 102 TCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTS- 160 + ++ +G+++A G + + IY++ R + R L+GH ++C + +N ++TS Sbjct: 67 SLSWIGAGSHLAVGQANGLVEIYDVMKR----KCIRTLSGHIDRVACLSW--NNHVLTSG 120 Query: 161 SGDTTCALWDIETGQQT-TTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCR 219 S D D+ T HT +V L SG D +++ Sbjct: 121 SRDHRILHRDVRMPDPFFETIESHTQEVCGLKWNVADNKLASGGNDNVVHVYEGTSKSPI 180 Query: 220 QTFTGHESDINAICFFPNGN---AFATGSDDATCRLFDLRADQELMTYSHDNIICGITSV 276 TF H++ + A+ + P+ A G+ D +++++ ++ + IC + Sbjct: 181 LTFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDIDSGSQICNMV-- 238 Query: 277 SFSKSGRLLLA--GYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDS 334 +SK+ L+ GY +N +WD D +L GH RV L +++DG V +G+ D Sbjct: 239 -WSKNTNELVTSHGYSKYNLTLWDCNSMDPIAILKGHSFRVLHLTLSNDGTTVVSGAGDE 297 Query: 335 FLKIW 339 L+ W Sbjct: 298 TLRYW 302 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 47/209 (22%), Positives = 81/209 (38%), Gaps = 46/209 (22%) Query: 49 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNK-VHAIPLRSSWVMTCAYAP 107 RTL GH+ ++ + W ++ +L S S+D +++ D + I + V + Sbjct: 98 RTLSGHIDRVACLSW--NNHVLTSGSRDHRILHRDVRMPDPFFETIESHTQEVCGLKWNV 155 Query: 108 SGNYVACGGLDNICSIYN-----------------------------LKTREG------- 131 + N +A GG DN+ +Y L T G Sbjct: 156 ADNKLASGGNDNVVHVYEGTSKSPILTFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLK 215 Query: 132 --NVRVSRELAGHTGYLSCCRFL---DDNQIVTSSGDT--TCALWDIETGQQTTTFTGHT 184 NV S +++ C + + N++VTS G + LWD + GH+ Sbjct: 216 IWNVNTSIKMSDIDSGSQICNMVWSKNTNELVTSHGYSKYNLTLWDCNSMDPIAILKGHS 275 Query: 185 GDVMSLSLAPDTRLFVSGACDASAKLWDV 213 V+ L+L+ D VSGA D + + W + Sbjct: 276 FRVLHLTLSNDGTTVVSGAGDETLRYWKL 304 >5K1B-B nrPDB Length = 677 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 43/196 (21%), Positives = 87/196 (44%), Gaps = 12/196 (6%) Query: 155 NQIVTSSGDTTCALWDIETGQQ---TTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLW 211 N++ T+ D+ +W + +Q + HT V + L + + +S + D + K+W Sbjct: 43 NRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVW 102 Query: 212 DVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIIC 271 + +G C T H+ + A+ + + A+ D L+D+ L T S++ + Sbjct: 103 NAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTAL-TASNNTVTT 161 Query: 272 G--------ITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDD 323 I S++ ++ G ++++G + VWD + L GH + V L + D Sbjct: 162 SSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRD 221 Query: 324 GMAVATGSWDSFLKIW 339 G +GS D +++W Sbjct: 222 GTQCLSGSSDGTIRLW 237 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 49/200 (24%), Positives = 85/200 (42%), Gaps = 12/200 (6%) Query: 66 DSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYN 125 + + L+SAS D + +W+++ + + +V AYA VA GLD +++ Sbjct: 86 NGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWD 145 Query: 126 LKT-----REGNVRVSRELAGHTGYLSCCRFLDDNQ----IVTSSGDTTCALWDIETGQQ 176 + T N + L+G+ + L NQ IV+ S + +WD T + Sbjct: 146 VNTLTALTASNNTVTTSSLSGNKDSIYS---LAMNQLGTIIVSGSTEKVLRVWDPRTCAK 202 Query: 177 TTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFP 236 GHT +V +L L D +SG+ D + +LW + + C T+ H+ + A+ Sbjct: 203 LMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVND 262 Query: 237 NGNAFATGSDDATCRLFDLR 256 +G D DLR Sbjct: 263 AFTHVYSGGRDRKIYCTDLR 282 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 56/250 (22%), Positives = 100/250 (40%), Gaps = 31/250 (12%) Query: 41 GRIQMRTRRTLRGHLAK-----IYAMHWGTDSRLLVSASQDGKLIIW-------DSYTTN 88 GR +++ +R + K + A+ L +A +D + IW D Y + Sbjct: 11 GRRKVQVSYVIRDEVEKYNRNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIAS 70 Query: 89 KVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSC 148 H + WV +G + D ++N +G + L H Y+ Sbjct: 71 MEH----HTDWVNDIVLCCNGKTLISASSDTTVKVWN--AHKGFCMST--LRTHKDYVKA 122 Query: 149 CRFLDDNQIVTSSG-DTTCALWDIET---------GQQTTTFTGHTGDVMSLSLAPDTRL 198 + D ++V S+G D LWD+ T T++ +G+ + SL++ + Sbjct: 123 LAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTI 182 Query: 199 FVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRAD 258 VSG+ + ++WD R GH ++ A+ +G +GS D T RL+ L Sbjct: 183 IVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQ 242 Query: 259 QELMTYS-HD 267 + + TY HD Sbjct: 243 RCIATYRVHD 252 >6J6H-n nrPDB Length = 455 Score = 62.8 bits (151), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 44/154 (28%), Positives = 75/154 (48%), Gaps = 13/154 (8%) Query: 108 SGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQ-IVTSSGDTTC 166 +G+ + GG D+ I++ + R+ GH + RF +D Q ++SS D + Sbjct: 174 TGHLILSGGNDHTIKIWDFYH---DYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSV 230 Query: 167 ALWDIETGQQTTTF--TGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVR----EGMCRQ 220 +WD ETG+ T DV S P F+ G ++ +D R +G+ Q Sbjct: 231 KIWDTETGKVKTRLHLNSTPADVESRPTNPHE--FIVGLSNSKILHYDDRVSENQGLV-Q 287 Query: 221 TFTGHESDINAICFFPNGNAFATGSDDATCRLFD 254 T+ H S I A+ +FP+G+ F + S+D T R+++ Sbjct: 288 TYDHHLSSILALKYFPDGSKFISSSEDKTVRIWE 321 Score = 42.4 bits (98), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 48/210 (22%), Positives = 83/210 (39%), Gaps = 6/210 (2%) Query: 49 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPS 108 R +GH I A+ + D + +S+S D + IWD+ T KV +S P+ Sbjct: 200 RDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDT-ETGKVKTRLHLNSTPADVESRPT 258 Query: 109 GNYVACGGLDNICSI-YNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCA 167 + GL N + Y+ + E V + L+ F D ++ ++SS D T Sbjct: 259 NPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVR 318 Query: 168 LWDIETGQQTTTFTGHTGDVMS-LSLAPDTRLFVSGACDASAKLWDVREGMCR---QTFT 223 +W+ + + M L++ P F + + D + ++ R + F Sbjct: 319 IWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFK 378 Query: 224 GHESDINAICFFPNGNAFATGSDDATCRLF 253 GH S I +G+ S D+ RLF Sbjct: 379 GHSSAGYGISLAFSGDGRYICSGDSKSRLF 408 Score = 38.1 bits (87), Expect = 0.005, Method: Compositional matrix adjust. Identities = 22/72 (30%), Positives = 38/72 (52%), Gaps = 4/72 (5%) Query: 272 GITSVSF-SKSGRLLLAGYDDFNCNVWDALKADRAGV--LAGHDNRVSCLGVTDDGMAVA 328 G T++ F K+G L+L+G +D +WD D + GH+ + L T+D + Sbjct: 164 GTTALKFLPKTGHLILSGGNDHTIKIWD-FYHDYECLRDFQGHNKPIKALRFTEDCQSFL 222 Query: 329 TGSWDSFLKIWN 340 + S+D +KIW+ Sbjct: 223 SSSFDRSVKIWD 234 >5OQL-L nrPDB Length = 557 Score = 61.6 bits (148), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 44/147 (29%), Positives = 72/147 (48%), Gaps = 10/147 (6%) Query: 157 IVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAP---DTRLFVSGACDASAKLWDV 213 +++ S D T LWD+ + T FTGHT V + P ++ L VSG+ D + ++WD Sbjct: 160 LMSCSDDKTVRLWDLPSNDPTRLFTGHTDYVRCGAFMPGSANSNLLVSGSYDETVRVWDA 219 Query: 214 R-EGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQEL-MTYSHDNIIC 271 R G TF H I + P+G S +A + DL A + L + +H Sbjct: 220 RAPGGAVMTFK-HADPIEDVLPLPSGTTLLAASGNAIS-VLDLVAAKPLRLITNHQKT-- 275 Query: 272 GITSVSFSKSGRLLLAGYDDFNCNVWD 298 +TS+S + GR +++G D + V++ Sbjct: 276 -VTSLSLASQGRRVVSGSLDGHVKVFE 301 Score = 40.0 bits (92), Expect = 0.001, Method: Compositional matrix adjust. Identities = 34/163 (20%), Positives = 64/163 (39%), Gaps = 8/163 (4%) Query: 54 HLAKIYAMHWG-TDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAP---SG 109 H ++ W T+ L+S S D + +WD + + + +V A+ P + Sbjct: 143 HKQPVWVTKWSPTELTTLMSCSDDKTVRLWDLPSNDPTRLFTGHTDYVRCGAFMPGSANS 202 Query: 110 NYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALW 169 N + G D +++ + G V + H + L + ++ ++ Sbjct: 203 NLLVSGSYDETVRVWDARAPGGAVMTFK----HADPIEDVLPLPSGTTLLAASGNAISVL 258 Query: 170 DIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWD 212 D+ + T H V SLSLA R VSG+ D K+++ Sbjct: 259 DLVAAKPLRLITNHQKTVTSLSLASQGRRVVSGSLDGHVKVFE 301 Score = 32.3 bits (72), Expect = 0.28, Method: Compositional matrix adjust. Identities = 30/139 (21%), Positives = 59/139 (42%), Gaps = 9/139 (6%) Query: 209 KLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQE---LMTYS 265 +++ +R+ +T +S+ + P+G G D ++FD+ L T+ Sbjct: 82 EIFSIRKREPLKTIGRFDSEAHCGEIRPDGRVLVAGEDTGRMQVFDVGQGTRAVILKTWH 141 Query: 266 HDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGM 325 +T S ++ L++ DD +WD D + GH + V C G G Sbjct: 142 IHKQPVWVTKWSPTEL-TTLMSCSDDKTVRLWDLPSNDPTRLFTGHTDYVRC-GAFMPGS 199 Query: 326 A----VATGSWDSFLKIWN 340 A + +GS+D +++W+ Sbjct: 200 ANSNLLVSGSYDETVRVWD 218 >6QDV-o nrPDB Length = 513 Score = 61.6 bits (148), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 65/303 (21%), Positives = 115/303 (37%), Gaps = 24/303 (7%) Query: 53 GHLAKIYAMH-WGTDSRLLVSASQDGKLIIWDSYTTNK-VHAIPLRSSWVMTCAYAPSGN 110 GH + A+ + LL+S S D K+ +W+ Y + + S V + +G Sbjct: 220 GHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNTAGT 279 Query: 111 YVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDD----NQIVTSSGDTTC 166 D +++ +T + R + + C +F D N V D Sbjct: 280 QFLSAAYDRYLKLWDTETGQCISRFTNRKVPY-----CVKFNPDEDKQNLFVAGMSDKKI 334 Query: 167 ALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGM-CRQTFTGH 225 WDI +G+ + H G V ++ + R FVS + D S ++W+ + + Sbjct: 335 VQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAEPS 394 Query: 226 ESDINAICFFPNGNAFATGSDDATCRLFD----LRADQELMTYSHDNIICGIT-SVSFSK 280 + A+ PNG A S D +F R +++ + H ++ G V FS Sbjct: 395 MHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGH--MVAGYACQVDFSP 452 Query: 281 SGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVT---DDGMAVATGSWDSFLK 337 +++G + N+WD HD C+G + V T WD +K Sbjct: 453 DMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDK--VCIGAVWHPHETSKVITCGWDGLIK 510 Query: 338 IWN 340 +W+ Sbjct: 511 LWD 513 >5YZG-W nrPDB Length = 579 Score = 61.2 bits (147), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 63/266 (23%), Positives = 95/266 (35%), Gaps = 62/266 (23%) Query: 131 GNVRVSRELAGHTGYL-SCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMS 189 G R R GH+ + C Q ++++ D LWD ETGQ + FT Sbjct: 320 GERRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVP-YC 378 Query: 190 LSLAPDT---RLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSD 246 + PD LFV+G D WD+R G Q + H +N I F F + SD Sbjct: 379 VKFNPDEDKQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSD 438 Query: 247 DATCRLF--DLRADQELMTYSHDNIICGITSVSFSKSGRLL------------------- 285 D + R++ D+ D Y + + + +V+ S +G+ L Sbjct: 439 DKSLRVWEWDIPVD---FKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFR 495 Query: 286 -----------LAGYD---DFN--------------CNVWDALKADRAGVLAGHDNRVSC 317 +AGY DF+ N+WD HD C Sbjct: 496 LNKKKIFKGHMVAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDK--VC 553 Query: 318 LGVT---DDGMAVATGSWDSFLKIWN 340 +G + V T WD +K+W+ Sbjct: 554 IGAVWHPHETSKVITCGWDGLIKLWD 579 Score = 45.4 bits (106), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 42/167 (25%), Positives = 73/167 (43%), Gaps = 12/167 (7%) Query: 54 HLAKIYAMHWGTDSRLLVSASQDGKLIIW--DSYTTNKVHAIPLRSSWVMTCAYAPSGNY 111 HL + + + ++R VS S D L +W D K A P S + +P+G + Sbjct: 417 HLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHS-MPAVTLSPNGKW 475 Query: 112 VACGGLDNICSIYNLKTREGNVRVSRE--LAGH--TGYLSCCRFLDD-NQIVTSSGDTTC 166 +AC +DN I+ + R R++++ GH GY F D + +++ G+ Sbjct: 476 LACQSMDNQILIFGAQNR---FRLNKKKIFKGHMVAGYACQVDFSPDMSYVISGDGNGKL 532 Query: 167 ALWDIETGQQTTTFTGHTGDVMSLSLAP-DTRLFVSGACDASAKLWD 212 +WD +T + + F H + P +T ++ D KLWD Sbjct: 533 NIWDWKTTKLYSRFKAHDKVCIGAVWHPHETSKVITCGWDGLIKLWD 579 >3JB9-g nrPDB Length = 558 Score = 60.8 bits (146), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 58/242 (23%), Positives = 103/242 (42%), Gaps = 34/242 (14%) Query: 108 SGNYVACGGLDNICSIYN-------LKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTS 160 SG+ + G +DN I+ L+T +G+ R R+L+ D +++ Sbjct: 278 SGHLLLSGSMDNQIKIWEVYHDRSLLRTFQGHARPIRDLSFSQ---------DGRSFLST 328 Query: 161 SGDTTCALWDIETGQQTTTF-TGHTGDVMSLSLAPD-TRLFVSGACDASAKLWDVREGMC 218 S D T LWD E G+ F + + + + PD F++G D +D+R Sbjct: 329 SFDKTIKLWDTELGKCLNCFNSDRLTNCVKFQVDPDKPNEFLAGTADKRILQFDIRSPDI 388 Query: 219 RQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSF 278 Q + H IN+I F NG F T SDD++ R ++ + + D + + V+ Sbjct: 389 VQAYDHHLGGINSITFLENGKRFVTTSDDSSMRFWEYGTPVPI-KFVADIAMHSMPRVAL 447 Query: 279 SKSGRLLLAGYDDFNC----NVWDALKADRAGVLAGHDNRVSC------LGVTDDGMAVA 328 +G+ + D NC + ++ + ++ V G+ SC +G + DG V Sbjct: 448 RPNGKSIACQSLD-NCIYVYSAYEKYRQNKKKVFKGY----SCSGYSLEVGFSPDGRFVF 502 Query: 329 TG 330 +G Sbjct: 503 SG 504 Score = 53.5 bits (127), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 47/182 (25%), Positives = 77/182 (42%), Gaps = 8/182 (4%) Query: 161 SGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDT-RLFVSGACDASAKLWDV-REGMC 218 G+ TC + + T+ GHT + L P + L +SG+ D K+W+V + Sbjct: 247 PGEQTCYI----PKKHIFTWKGHTKGISCLRFFPISGHLLLSGSMDNQIKIWEVYHDRSL 302 Query: 219 RQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNII-CGITSVS 277 +TF GH I + F +G +F + S D T +L+D + L ++ D + C V Sbjct: 303 LRTFQGHARPIRDLSFSQDGRSFLSTSFDKTIKLWDTELGKCLNCFNSDRLTNCVKFQVD 362 Query: 278 FSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLK 337 K LAG D +D D H ++ + ++G T S DS ++ Sbjct: 363 PDKPNE-FLAGTADKRILQFDIRSPDIVQAYDHHLGGINSITFLENGKRFVTTSDDSSMR 421 Query: 338 IW 339 W Sbjct: 422 FW 423 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 43/166 (25%), Positives = 74/166 (44%), Gaps = 9/166 (5%) Query: 54 HLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMT-CAYAPSGNYV 112 HL I ++ + + + V+ S D + W+ T + + + M A P+G + Sbjct: 395 HLGGINSITFLENGKRFVTTSDDSSMRFWEYGTPVPIKFVADIAMHSMPRVALRPNGKSI 454 Query: 113 ACGGLDNICSIYNL--KTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTT--CAL 168 AC LDN +Y+ K R+ +V + + +GY F D + V SGD++ Sbjct: 455 ACQSLDNCIYVYSAYEKYRQNKKKVFKGYSC-SGYSLEVGFSPDGRFVF-SGDSSGNACF 512 Query: 169 WDIETGQQTTTFTGHTGDVMSLSLAPD--TRLFVSGACDASAKLWD 212 WD +T + H+G V S++ P +++ S D S K WD Sbjct: 513 WDWKTCKLMAKLPAHSGPVQSMAFHPQETSKVATSSIVDGSIKYWD 558 Score = 40.0 bits (92), Expect = 0.001, Method: Compositional matrix adjust. Identities = 57/305 (18%), Positives = 101/305 (33%), Gaps = 63/305 (20%) Query: 49 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPS 108 RT +GH I + + D R +S S D + +WD+ Sbjct: 304 RTFQGHARPIRDLSFSQDGRSFLSTSFDKTIKLWDTEL---------------------- 341 Query: 109 GNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDD----NQIVTSSGDT 164 G + C D + +C +F D N+ + + D Sbjct: 342 GKCLNCFNSDRLT-------------------------NCVKFQVDPDKPNEFLAGTADK 376 Query: 165 TCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTG 224 +DI + + H G + S++ + + FV+ + D+S + W+ + + Sbjct: 377 RILQFDIRSPDIVQAYDHHLGGINSITFLENGKRFVTTSDDSSMRFWEYGTPVPIKFVAD 436 Query: 225 -HESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGIT------SVS 277 + + PNG + A S D ++ + E + + G + V Sbjct: 437 IAMHSMPRVALRPNGKSIACQSLDNCIYVY---SAYEKYRQNKKKVFKGYSCSGYSLEVG 493 Query: 278 FSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGV-TDDGMAVATGSW-DSF 335 FS GR + +G N WD L H V + + VAT S D Sbjct: 494 FSPDGRFVFSGDSSGNACFWDWKTCKLMAKLPAHSGPVQSMAFHPQETSKVATSSIVDGS 553 Query: 336 LKIWN 340 +K W+ Sbjct: 554 IKYWD 558 Score = 35.8 bits (81), Expect = 0.028, Method: Compositional matrix adjust. Identities = 20/65 (30%), Positives = 32/65 (49%), Gaps = 3/65 (4%) Query: 278 FSKSGRLLLAGYDDFNCNVWDALKADRA--GVLAGHDNRVSCLGVTDDGMAVATGSWDSF 335 F SG LLL+G D +W+ DR+ GH + L + DG + + S+D Sbjct: 275 FPISGHLLLSGSMDNQIKIWEVYH-DRSLLRTFQGHARPIRDLSFSQDGRSFLSTSFDKT 333 Query: 336 LKIWN 340 +K+W+ Sbjct: 334 IKLWD 338 Score = 28.9 bits (63), Expect = 3.4, Method: Compositional matrix adjust. Identities = 15/68 (22%), Positives = 28/68 (41%), Gaps = 2/68 (2%) Query: 42 RIQMRTRRTLRGHLAKIYAMHWG--TDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSW 99 + + ++ +G+ Y++ G D R + S G WD T + +P S Sbjct: 471 KYRQNKKKVFKGYSCSGYSLEVGFSPDGRFVFSGDSSGNACFWDWKTCKLMAKLPAHSGP 530 Query: 100 VMTCAYAP 107 V + A+ P Sbjct: 531 VQSMAFHP 538 >4U1E-I nrPDB Length = 347 Score = 60.1 bits (144), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 55/219 (25%), Positives = 98/219 (44%), Gaps = 21/219 (9%) Query: 138 ELAGHTGYLSCCRFLDDNQIVTS-SGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDT 196 +L GH L+ ++ + ++ S S D++ ++W G++ T GHTG + S+ + T Sbjct: 5 KLTGHERPLTQVKYNKEGDLLFSCSKDSSASVWYSLNGERLGTLDGHTGTIWSIDVDCFT 64 Query: 197 RLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDA-----TCR 251 + V+G+ D S KLWDV G C T+ + + F P GN F D+ + Sbjct: 65 KYCVTGSADYSIKLWDVSNGQCVATWKS-PVPVKRVEFSPCGNYFLAILDNVMKNPGSIN 123 Query: 252 LFDLRAD---QELMTYSHDNI--------ICGITSVSFSKSGRLLLAGYDDFNCNVWDAL 300 ++++ D EL S + I + T +S G+ ++AG+ D + +D Sbjct: 124 IYEIERDSATHELTKVSEEPIHKIITHEGLDAATVAGWSTKGKYIIAGHKDGKISKYDVS 183 Query: 301 -KADRAGVLAGHDNRVSCLGVTDDGMAVATGSWD--SFL 336 + + H+ +S + + D T S D SFL Sbjct: 184 NNYEYVDSIDLHEKSISDMQFSPDLTYFITSSRDTNSFL 222 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 22/68 (32%), Positives = 35/68 (51%) Query: 273 ITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSW 332 +T V ++K G LL + D + +VW +L +R G L GH + + V TGS Sbjct: 13 LTQVKYNKEGDLLFSCSKDSSASVWYSLNGERLGTLDGHTGTIWSIDVDCFTKYCVTGSA 72 Query: 333 DSFLKIWN 340 D +K+W+ Sbjct: 73 DYSIKLWD 80 Score = 39.3 bits (90), Expect = 0.003, Method: Compositional matrix adjust. Identities = 60/313 (19%), Positives = 111/313 (35%), Gaps = 64/313 (20%) Query: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKV----HAIPLRSSWVMTCAY 105 TL GH I+++ ++ V+ S D + +WD V +P++ + Sbjct: 47 TLDGHTGTIWSIDVDCFTKYCVTGSADYSIKLWDVSNGQCVATWKSPVPVKR-----VEF 101 Query: 106 APSGNYVACGGLDNICSIYNLKTREGNV---RVSRELAGHTGYLSCCRFLDDNQIVTSSG 162 +P GNY LDN+ G++ + R+ A H L+ ++I+T G Sbjct: 102 SPCGNYF-LAILDNVMK------NPGSINIYEIERDSATHE--LTKVSEEPIHKIITHEG 152 Query: 163 --DTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGM-CR 219 T A W + + ++G D +DV Sbjct: 153 LDAATVAGWSTKG-----------------------KYIIAGHKDGKISKYDVSNNYEYV 189 Query: 220 QTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFS 279 + HE I+ + F P+ F T S D L D+ Q L Y D C + + + Sbjct: 190 DSIDLHEKSISDMQFSPDLTYFITSSRDTNSFLVDVSTLQVLKKYETD---CPLNTAVIT 246 Query: 280 KSGRLLLAG--------------YDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGM 325 ++ G F + + + G + GH ++ + ++ G Sbjct: 247 PLKEFIILGGGQEAKDVTTTSANEGKFEARFYHKIFEEEIGRVQGHFGPLNTVAISPQGT 306 Query: 326 AVATGSWDSFLKI 338 + A+G D F+++ Sbjct: 307 SYASGGEDGFIRL 319 Score = 34.3 bits (77), Expect = 0.083, Method: Compositional matrix adjust. Identities = 43/183 (23%), Positives = 67/183 (36%), Gaps = 32/183 (17%) Query: 103 CAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDD-NQIVTSS 161 ++ G Y+ G D S Y++ N + H +S +F D +TSS Sbjct: 159 AGWSTKGKYIIAGHKDGKISKYDVSN---NYEYVDSIDLHEKSISDMQFSPDLTYFITSS 215 Query: 162 GDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDV-----REG 216 DT L D+ T Q + T ++ ++ + F+ AK DV EG Sbjct: 216 RDTNSFLVDVSTLQVLKKY--ETDCPLNTAVITPLKEFIILGGGQEAK--DVTTTSANEG 271 Query: 217 MCRQTF------------TGHESDINAICFFPNGNAFATGSDDATCRL-------FDLRA 257 F GH +N + P G ++A+G +D RL FD + Sbjct: 272 KFEARFYHKIFEEEIGRVQGHFGPLNTVAISPQGTSYASGGEDGFIRLHHFEKSYFDFKY 331 Query: 258 DQE 260 D E Sbjct: 332 DVE 334 >5WBU-D nrPDB Length = 328 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 42/178 (23%), Positives = 76/178 (42%), Gaps = 13/178 (7%) Query: 70 LVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTR 129 L+ Q G + IWD T + IP + + P +Y+A C ++NL Sbjct: 145 LIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGG 204 Query: 130 EGN----VRVSRELAGHTGYLSCCRFLDDNQIV-TSSGDTTCALWDIETGQQTTTFTGHT 184 G+ + ++ HT Y CRF D+ ++ T S D TC +W T + + Sbjct: 205 IGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKS 264 Query: 185 GD--------VMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICF 234 G+ + + + D++ V+ + D A+LW V G ++ + GH+ + + F Sbjct: 265 GNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAF 322 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 26/108 (24%), Positives = 49/108 (45%), Gaps = 1/108 (0%) Query: 191 SLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATC 250 ++ D + + D + + W G+C +T +S +NA+ P+ + A Sbjct: 9 TVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHI- 67 Query: 251 RLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWD 298 R++DL ++ S+D + I SV F + GR + G +D +WD Sbjct: 68 RMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWD 115 Score = 42.0 bits (97), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 36/150 (24%), Positives = 63/150 (42%), Gaps = 5/150 (3%) Query: 157 IVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREG 216 + T+ D T W +G T T V +L + PD R ++ A +++D+ Sbjct: 17 LATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPD-RSMIAAAGYQHIRMYDLNSN 75 Query: 217 MCRQ--TFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGIT 274 ++ G +I ++ F +G TG +D T R++DLR+ + L + I Sbjct: 76 NPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRS-RNLQCQRIFQVNAPIN 134 Query: 275 SVSFSKSGRLLLAGYDDFNCNVWDALKADR 304 V + L+ G ++WD LK D Sbjct: 135 CVCLHPNQAELIVGDQSGAIHIWD-LKTDH 163 Score = 41.2 bits (95), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 44/237 (18%), Positives = 83/237 (35%), Gaps = 49/237 (20%) Query: 64 GTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSI 123 G+D +L +A D + W +++ + + S V P + +A G +I + Sbjct: 11 GSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHI-RM 69 Query: 124 YNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGH 183 Y+L + N +S + G ++ F +D + + + G+ Sbjct: 70 YDLNSNNPNPIISYD--GVNKNIASVGFHEDGRWMYTGGE-------------------- 107 Query: 184 TGDVMSLSLAPDTRLFVSGACDASAKLWDVREG--MCRQTFTGHESDINAICFFPNGNAF 241 D +A++WD+R C++ F + + IN +C PN Sbjct: 108 ---------------------DCTARIWDLRSRNLQCQRIFQVN-APINCVCLHPNQAEL 145 Query: 242 ATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWD 298 G ++DL+ D + ITS + A NC VW+ Sbjct: 146 IVGDQSGAIHIWDLKTDHNEQLIPEPEV--SITSAHIDPDASYMAAVNSTGNCYVWN 200 Score = 39.3 bits (90), Expect = 0.003, Method: Compositional matrix adjust. Identities = 48/289 (16%), Positives = 105/289 (36%), Gaps = 17/289 (5%) Query: 49 RTLRGHLAKIYAMHWGTDSRLLVSAS-QDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAP 107 RT++ +++ A+ D ++ +A Q ++ +S N + + + + + + Sbjct: 38 RTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHE 97 Query: 108 SGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCA 167 G ++ GG D I++L++R N++ R + C + +++ Sbjct: 98 DGRWMYTGGEDCTARIWDLRSR--NLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIH 155 Query: 168 LWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGM--------CR 219 +WD++T + S + PD + + +W++ G+ + Sbjct: 156 IWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPK 215 Query: 220 QTFTGHESDINAICFFPNGNAFATGSDDATCRL-----FDLRADQELMTYSHDNIICG-I 273 H F P+ AT S D TC++ F L + + + + G + Sbjct: 216 TKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWM 275 Query: 274 TSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTD 322 +FS + ++ D +W + GH V CL D Sbjct: 276 WGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFND 324 >5MWJ-A nrPDB Length = 337 Score = 58.9 bits (141), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 48/198 (24%), Positives = 84/198 (42%), Gaps = 7/198 (3%) Query: 145 YLSCCRFLDDNQIVTSSGD-TTCALWDI--ETGQQTTTFTGHTGDVMSLSLAPDTRLFVS 201 Y+ C+ L D + G+ +T ++WD+ T + T +L+++PD+++ S Sbjct: 99 YIRSCKLLPDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFS 158 Query: 202 GACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQEL 261 D + +WD+ + F GH + I +G TG D T R +DLR ++L Sbjct: 159 CCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQL 218 Query: 262 MTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVT 321 + + I S+ + +G L G + N V K D+ L H++ V L Sbjct: 219 QQH---DFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDKYQ-LHLHESCVLSLKFA 274 Query: 322 DDGMAVATGSWDSFLKIW 339 G + D+ L W Sbjct: 275 YCGKWFVSTGKDNLLNAW 292 Score = 58.2 bits (139), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 52/229 (22%), Positives = 95/229 (41%), Gaps = 16/229 (6%) Query: 77 GKLIIWD-SYTTNKVHAIPL----RSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREG 131 G + +WD S+ NK L R +++ +C P G + GG + SI++L Sbjct: 72 GCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCKLLPDGCTLIVGGEASTLSIWDLAAP-- 129 Query: 132 NVRVSRELAGHTGYLSCCRFLDDNQIVTS-SGDTTCALWDIETGQQTTTFTGHTGDVMSL 190 R+ EL D+++ S D A+WD+ F GHT + Sbjct: 130 TPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCI 189 Query: 191 SLAPDTRLFVSGACDASAKLWDVREG--MCRQTFTGHESDINAICFFPNGNAFATGSDDA 248 ++ D +G D + + WD+REG + + FT S I ++ + P G A G + + Sbjct: 190 DISNDGTKLWTGGLDNTVRSWDLREGRQLQQHDFT---SQIFSLGYCPTGEWLAVGMESS 246 Query: 249 TCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVW 297 + + + + H++ + S+ F+ G+ ++ D N W Sbjct: 247 NVEVLHVNKPDKYQLHLHESC---VLSLKFAYCGKWFVSTGKDNLLNAW 292 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 32/163 (19%), Positives = 68/163 (41%), Gaps = 6/163 (3%) Query: 183 HTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFT-----GHESDINAICFFPN 237 H V +++++ TR +G K+WD+ + + ++ I + P+ Sbjct: 50 HGEVVCAVTISNPTRHVYTGG-KGCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCKLLPD 108 Query: 238 GNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVW 297 G G + +T ++DL A + + +++ S ++ + D N VW Sbjct: 109 GCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVW 168 Query: 298 DALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 D GH + SC+ +++DG + TG D+ ++ W+ Sbjct: 169 DLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWD 211 Score = 31.2 bits (69), Expect = 0.71, Method: Compositional matrix adjust. Identities = 30/130 (23%), Positives = 61/130 (46%), Gaps = 9/130 (6%) Query: 45 MRTRRTLRGH--LAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMT 102 +R R L+ H ++I+++ + L + + + +K + + L S V++ Sbjct: 212 LREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDK-YQLHLHESCVLS 270 Query: 103 CAYAPSGNYVACGGLDNICSIYNLKTREG-NVRVSRELAGHTGYLSCCRFLDDNQIVTSS 161 +A G + G DN+ + + +T G ++ S+E + LSC +DD IVT S Sbjct: 271 LKFAYCGKWFVSTGKDNLLNAW--RTPYGASIFQSKE---SSSVLSCDISVDDKYIVTGS 325 Query: 162 GDTTCALWDI 171 GD ++++ Sbjct: 326 GDKKATVYEV 335 Score = 30.8 bits (68), Expect = 0.95, Method: Compositional matrix adjust. Identities = 25/97 (25%), Positives = 38/97 (39%), Gaps = 7/97 (7%) Query: 46 RTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAY 105 R + L YA+ DS++ S DG + +WD + V + Sbjct: 132 RIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDI 191 Query: 106 APSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGH 142 + G + GGLDN ++L REG R+L H Sbjct: 192 SNDGTKLWTGGLDNTVRSWDL--REG-----RQLQQH 221 >5XYI-g nrPDB Length = 335 Score = 58.2 bits (139), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 49/229 (21%), Positives = 102/229 (44%), Gaps = 26/229 (11%) Query: 47 TRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLR-SSWVMTCAY 105 T++ GH + + + +R ++S +D ++ IW+ NK L+ SSWV + A Sbjct: 114 TKKLFLGHKKDVLGVTFSPCNRRIISVGRDNQVKIWNILGENKAE---LQCSSWVTSVAC 170 Query: 106 APSGN-----YVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQ-IVT 159 AP + +A G D I+++ E ++ +E H G + F D + ++T Sbjct: 171 APMADETSPLVIAVGCWDGKVYIWSI---EKEAKLIKEFKAHDGRCTSVDFTPDGKWVIT 227 Query: 160 SSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDV----RE 215 D +W E G +T +FT + V +++ P T+ ++ A +WD+ + Sbjct: 228 GGSDRKVVMWLTENGAKTISFTAPS-PVHAVAACP-TQAWICAATYEGIAVWDIGAKQQI 285 Query: 216 GMCRQTF-------TGHESDINAICFFPNGNAFATGSDDATCRLFDLRA 257 + + F G D + + +G+ +G +D + R +++++ Sbjct: 286 DLVQPNFKHEGKRNAGRTPDCTCLAWAADGSVLYSGYNDGSIRAWEVKS 334 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 49/202 (24%), Positives = 85/202 (42%), Gaps = 24/202 (11%) Query: 110 NYVACGGLDNICSIYNL-KTREGNVRVSRELAGHTGYLSCCRF-LDDNQIVTSSGDTTCA 167 NY+ D ++ L +T+E L GH ++S D + ++TSS D+T Sbjct: 46 NYLVSASRDKSALVWKLNRTQEQWATPFTRLIGHNHFVSDVSLSRDASHLLTSSWDSTLR 105 Query: 168 LWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDV-----REGMCRQTF 222 LWD+ T F GH DV+ ++ +P R +S D K+W++ E C Sbjct: 106 LWDLSTRTTKKLFLGHKKDVLGVTFSPCNRRIISVGRDNQVKIWNILGENKAELQC---- 161 Query: 223 TGHESDINAICFFPNGN-----AFATGSDDATCRLFDLRADQELMT--YSHDNIICGITS 275 S + ++ P + A G D ++ + + +L+ +HD TS Sbjct: 162 ---SSWVTSVACAPMADETSPLVIAVGCWDGKVYIWSIEKEAKLIKEFKAHDG---RCTS 215 Query: 276 VSFSKSGRLLLAGYDDFNCNVW 297 V F+ G+ ++ G D +W Sbjct: 216 VDFTPDGKWVITGGSDRKVVMW 237 Score = 53.9 bits (128), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 57/267 (21%), Positives = 111/267 (41%), Gaps = 22/267 (8%) Query: 51 LRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWD--SYTTNKVHAIPLRSSWVMTCAYAPS 108 L GH + + D+ L+++S D L +WD + TT K+ + V+ ++P Sbjct: 76 LIGHNHFVSDVSLSRDASHLLTSSWDSTLRLWDLSTRTTKKLFLGHKKD--VLGVTFSPC 133 Query: 109 GNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDD-NQIVTSSG--DTT 165 + G DN I+N+ G + + + ++C D+ + +V + G D Sbjct: 134 NRRIISVGRDNQVKIWNIL---GENKAELQCSSWVTSVACAPMADETSPLVIAVGCWDGK 190 Query: 166 CALWDIET-GQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTG 224 +W IE + F H G S+ PD + ++G D +W G +FT Sbjct: 191 VYIWSIEKEAKLIKEFKAHDGRCTSVDFTPDGKWVITGGSDRKVVMWLTENGAKTISFTA 250 Query: 225 HESDINAICFFPNGNAFATGSDDATCRLFDLRADQEL----MTYSHDNI-----ICGITS 275 S ++A+ P A+ + ++D+ A Q++ + H+ T Sbjct: 251 -PSPVHAVAACPT-QAWICAATYEGIAVWDIGAKQQIDLVQPNFKHEGKRNAGRTPDCTC 308 Query: 276 VSFSKSGRLLLAGYDDFNCNVWDALKA 302 ++++ G +L +GY+D + W+ A Sbjct: 309 LAWAADGSVLYSGYNDGSIRAWEVKSA 335 Score = 52.8 bits (125), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 44/172 (25%), Positives = 79/172 (45%), Gaps = 14/172 (8%) Query: 179 TFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVR--EGMCRQTFT---GHESDINAIC 233 TF GH + S+ + + VS + D SA +W + + FT GH ++ + Sbjct: 28 TFVGHNAAIESIEIDNEHNYLVSASRDKSALVWKLNRTQEQWATPFTRLIGHNHFVSDVS 87 Query: 234 FFPNGNAFATGSDDATCRLFDL--RADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDD 291 + + T S D+T RL+DL R ++L H + G+T FS R +++ D Sbjct: 88 LSRDASHLLTSSWDSTLRLWDLSTRTTKKLF-LGHKKDVLGVT---FSPCNRRIISVGRD 143 Query: 292 FNCNVWDALKADRAGV-LAGHDNRVSCLGVTDD--GMAVATGSWDSFLKIWN 340 +W+ L ++A + + V+C + D+ + +A G WD + IW+ Sbjct: 144 NQVKIWNILGENKAELQCSSWVTSVACAPMADETSPLVIAVGCWDGKVYIWS 195 Score = 36.6 bits (83), Expect = 0.016, Method: Compositional matrix adjust. Identities = 35/128 (27%), Positives = 52/128 (40%), Gaps = 9/128 (7%) Query: 219 RQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICG---ITS 275 R TF GH + I +I N + S D + ++ L QE +I ++ Sbjct: 26 RATFVGHNAAIESIEIDNEHNYLVSASRDKSALVWKLNRTQEQWATPFTRLIGHNHFVSD 85 Query: 276 VSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTD---DGMAVATGSW 332 VS S+ LL D +WD + GH V LGVT + ++ G Sbjct: 86 VSLSRDASHLLTSSWDSTLRLWDLSTRTTKKLFLGHKKDV--LGVTFSPCNRRIISVGR- 142 Query: 333 DSFLKIWN 340 D+ +KIWN Sbjct: 143 DNQVKIWN 150 >5OQL-J nrPDB Length = 912 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 78/347 (22%), Positives = 122/347 (35%), Gaps = 75/347 (21%) Query: 66 DSRLLVSASQDGKLIIWDSYTTNKV---HAIPLRSSWVMTCAYAPSGNYVACGGLDNICS 122 + + + SA G L IWD+ T +++ +++ P + + C D Sbjct: 285 EGKWMYSAGTSGVLRIWDTTTHHEITKKQDAKSEGEAILSAVSLPERSLILCAQADFTLV 344 Query: 123 IYNLKTREGNVRVS--------RELAG-HTGYLSCCRFLDDNQ---IVTSSGDT-TCALW 169 +Y + + V S R ++G H L L D I T+S D ++ Sbjct: 345 LYRVPSPADVVSSSEGILLEPFRRISGTHDEILDLTYILPDQSMMAIATNSEDIRIVSVK 404 Query: 170 DIET--------------GQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVRE 215 D + G GH VMSL + SG+ D +A+LW V Sbjct: 405 DAQAYSEDNAECRSGSYFGHDVALLKGHEDIVMSLDVDWSGHWIASGSKDNTARLWRVDP 464 Query: 216 G----MCRQTFTGHESDINAICF---FPNGNAFA-------------TGSDDATCRLFDL 255 C FTGH + A+ P N+ A +GS D + D+ Sbjct: 465 ANNSYTCYAVFTGHLESVGAVALPKVVPPANSEAFKNPLDHPPAFLISGSQDRFVQKRDI 524 Query: 256 --------RADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGV 307 + L +HD I ++ S +G+L + D +WD K + G+ Sbjct: 525 PRQLQKGGKLTSSLRRLAHDK---DINALDISPNGKLFASASQDKTVKIWDVEKLEVQGI 581 Query: 308 LAGHDN-----RVSCL---------GVTDDGMAVATGSWDSFLKIWN 340 L GH R + L G V TGS D +K+WN Sbjct: 582 LRGHKRGVWTVRFAPLNTPVIQGEQGSVSGRGVVLTGSGDKTIKLWN 628 Score = 52.0 bits (123), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 41/179 (22%), Positives = 74/179 (41%), Gaps = 21/179 (11%) Query: 182 GHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAF 241 H D+ +L ++P+ +LF S + D + K+WDV + + GH+ + + F P Sbjct: 542 AHDKDINALDISPNGKLFASASQDKTVKIWDVEKLEVQGILRGHKRGVWTVRFAPLNTPV 601 Query: 242 A--------------TGSDDATCRLFDLRADQELMTYS-HDNIICGITSV------SFSK 280 TGS D T +L++L + T+ H + + + + S +K Sbjct: 602 IQGEQGSVSGRGVVLTGSGDKTIKLWNLSDYTCIRTFEGHSHNVLKVVWLHISRDDSITK 661 Query: 281 SGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIW 339 + + D VWDA + L H++R+ L V +A+ DS + W Sbjct: 662 TKVQFASAGADTLVKVWDANTGETECTLDNHEDRLWTLAVHSKTNILASAGSDSKVTFW 720 Score = 41.6 bits (96), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 33/161 (20%), Positives = 65/161 (40%), Gaps = 7/161 (4%) Query: 179 TFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNG 238 T H V+ L++ + L +GA D + K+WD+ G T +G ++A+ FF Sbjct: 106 TTKPHATPVVVLAVDRTSTLLATGAADGAIKIWDIIGGYVTHTVSGPSVLVSALHFF--- 162 Query: 239 NAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWD 298 A ++ + + ++ D I ++ GR+ + D Sbjct: 163 -EIAVTAESQSSNKKPKKGSRKGQNDDADEIASRFRLAWGTQDGRIRIF---DLYKRTTT 218 Query: 299 ALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIW 339 + AD H++ V C+ + + A+ +GS D + +W Sbjct: 219 PVYADPKRKKEAHESNVQCIAYSPEQHALLSGSRDKTMTLW 259 Score = 41.6 bits (96), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 44/199 (22%), Positives = 72/199 (36%), Gaps = 22/199 (11%) Query: 33 ITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHA 92 I + G++ RR H I A+ + +L SASQD + IWD Sbjct: 524 IPRQLQKGGKLTSSLRRL--AHDKDINALDISPNGKLFASASQDKTVKIWDVEKLEVQGI 581 Query: 93 IPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVS----------RELAGH 142 + V T +AP V G ++ + T G+ + R GH Sbjct: 582 LRGHKRGVWTVRFAPLNTPVIQGEQGSVSGRGVVLTGSGDKTIKLWNLSDYTCIRTFEGH 641 Query: 143 TGYLSCCRFL----DDN------QIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSL 192 + + +L DD+ Q ++ DT +WD TG+ T H + +L++ Sbjct: 642 SHNVLKVVWLHISRDDSITKTKVQFASAGADTLVKVWDANTGETECTLDNHEDRLWTLAV 701 Query: 193 APDTRLFVSGACDASAKLW 211 T + S D+ W Sbjct: 702 HSKTNILASAGSDSKVTFW 720 Score = 35.8 bits (81), Expect = 0.030, Method: Compositional matrix adjust. Identities = 60/351 (17%), Positives = 125/351 (35%), Gaps = 61/351 (17%) Query: 48 RRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIP-LRSSWVMTCAYA 106 +R H + + + + + L+S S+D + +W + P LR + + + Sbjct: 225 KRKKEAHESNVQCIAYSPEQHALLSGSRDKTMTLW-LWRDGIWQGTPMLRHELLESVGFL 283 Query: 107 PSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTC 166 G ++ G + I++ T + + LS + + I+ + D T Sbjct: 284 NEGKWMYSAGTSGVLRIWDTTTHHEITKKQDAKSEGEAILSAVSLPERSLILCAQADFTL 343 Query: 167 ALWDIETGQQTTT------------FTGHTGDVMSLS-LAPDTRLFVSGACDASAKLWDV 213 L+ + + + +G +++ L+ + PD + ++ V Sbjct: 344 VLYRVPSPADVVSSSEGILLEPFRRISGTHDEILDLTYILPDQSMMAIATNSEDIRIVSV 403 Query: 214 REGM--------CRQ---------TFTGHESDINAICFFPNGNAFATGSDDATCRLFDLR 256 ++ CR GHE + ++ +G+ A+GS D T RL+ R Sbjct: 404 KDAQAYSEDNAECRSGSYFGHDVALLKGHEDIVMSLDVDWSGHWIASGSKDNTARLW--R 461 Query: 257 ADQELMTYSHDNIICG----ITSVSFSK----------------SGRLLLAGYDDFNCNV 296 D +Y+ + G + +V+ K L++G D Sbjct: 462 VDPANNSYTCYAVFTGHLESVGAVALPKVVPPANSEAFKNPLDHPPAFLISGSQDRFVQK 521 Query: 297 WDALKA-DRAGVLA------GHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 D + + G L HD ++ L ++ +G A+ S D +KIW+ Sbjct: 522 RDIPRQLQKGGKLTSSLRRLAHDKDINALDISPNGKLFASASQDKTVKIWD 572 Score = 34.3 bits (77), Expect = 0.071, Method: Compositional matrix adjust. Identities = 47/231 (20%), Positives = 84/231 (36%), Gaps = 44/231 (19%) Query: 49 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWD---SYTTNKVHAIPLRSS-----WV 100 RT + H + + S LL + + DG + IWD Y T+ V + S + Sbjct: 105 RTTKPHATPVVVLAVDRTSTLLATGAADGAIKIWDIIGGYVTHTVSGPSVLVSALHFFEI 164 Query: 101 MTCAYAPSGNYVACGG--------LDNICSIYNLK--TREGNVRVSRELAGHTGYLSCCR 150 A + S N G D I S + L T++G +R+ +L T Sbjct: 165 AVTAESQSSNKKPKKGSRKGQNDDADEIASRFRLAWGTQDGRIRIF-DLYKRT------- 216 Query: 151 FLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKL 210 TT D + ++ H +V ++ +P+ +SG+ D + L Sbjct: 217 -------------TTPVYADPKRKKE-----AHESNVQCIAYSPEQHALLSGSRDKTMTL 258 Query: 211 WDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQEL 261 W R+G+ + T + ++ F G + R++D E+ Sbjct: 259 WLWRDGIWQGTPMLRHELLESVGFLNEGKWMYSAGTSGVLRIWDTTTHHEI 309 >6CHG-A nrPDB Length = 312 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 51/217 (23%), Positives = 92/217 (42%), Gaps = 16/217 (7%) Query: 91 HAIPLRSSWVMTCAYAPSGNYVA-CGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSC- 148 +P +C +P G +A C D + +Y + + ++ + H ++C Sbjct: 7 QVLPASGKISTSCQISPDGELIAICQNTDML--VYEISSS----KMMKLTTTHKECINCL 60 Query: 149 CRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASA 208 C D I + S D T + I G+ GHT V+S+ + S + D S Sbjct: 61 CWSPDSKCIASGSEDFTVEITHIIYGR-IRRLMGHTAPVISICYNNKGNILCSSSMDESI 119 Query: 209 KLWDVREGMCRQTFTGHESDINAICFFP-NGNAFATGSDDATCRLFDLRADQELMTYSHD 267 K W V G +T + H + +I + + ++GS D R+FD + L T ++D Sbjct: 120 KEWHVLSGTALKTMSAHSDAVVSIDIPKFDSSILSSGSYDGLIRIFDTESGHCLKTLTYD 179 Query: 268 ------NIICGITSVSFSKSGRLLLAGYDDFNCNVWD 298 + + I++V FS++G+ LL D +W+ Sbjct: 180 KDWIAEDGVVPISTVKFSRNGKFLLVKSLDNVVKLWE 216 Score = 40.8 bits (94), Expect = 9e-04, Method: Compositional matrix adjust. Identities = 64/318 (20%), Positives = 113/318 (35%), Gaps = 75/318 (23%) Query: 6 QLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLR---GHLAKIYAMH 62 Q ++ +I + + D L I N D + ++ + + ++ H I + Sbjct: 3 QFDKQVLPASGKISTSCQISPDGELIAICQNTDML-VYEISSSKMMKLTTTHKECINCLC 61 Query: 63 WGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICS 122 W DS+ + S S+D +T H I R Sbjct: 62 WSPDSKCIASGSED--------FTVEITHIIYGR-------------------------- 87 Query: 123 IYNLKTREGNVRVSRELAGHTG-YLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFT 181 R L GHT +S C N + +SS D + W + +G T + Sbjct: 88 -------------IRRLMGHTAPVISICYNNKGNILCSSSMDESIKEWHVLSGTALKTMS 134 Query: 182 GHTGDVMSLSLAP-DTRLFVSGACDASAKLWDVREGMCRQTFTGHESD---------INA 231 H+ V+S+ + D+ + SG+ D +++D G C +T T ++ D I+ Sbjct: 135 AHSDAVVSIDIPKFDSSILSSGSYDGLIRIFDTESGHCLKTLT-YDKDWIAEDGVVPIST 193 Query: 232 ICFFPNGNAFATGSDDATCRLFD----------LRADQELMTYSHDNIICGITSVSFSKS 281 + F NG S D +L++ L QE N CG+ + Sbjct: 194 VKFSRNGKFLLVKSLDNVVKLWEYTRGTVVRTFLWPHQETKAKLKYN--CGLELIYPQGK 251 Query: 282 GRLLLAGYDDFNCNVWDA 299 L+++G D + VW+ Sbjct: 252 DPLVISGNDSGSMCVWNV 269 >5Y1U-A nrPDB Length = 456 Score = 53.9 bits (128), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 50/159 (31%), Positives = 70/159 (44%), Gaps = 14/159 (8%) Query: 156 QIVTSSGDTTCALWDIETGQQ-------TTTFTGHTGDVMSLSLAP-DTRLFVSGACDAS 207 ++++S D T LWDI + T FTGHT V +S LF S A D Sbjct: 223 HLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQK 282 Query: 208 AKLWDVREG---MCRQTFTGHESDINAICFFPNGN-AFATGSDDATCRLFDLRADQELMT 263 +WD R + H +++N + F P ATGS D T L+DLR + +L Sbjct: 283 LMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLR-NLKLKL 341 Query: 264 YSHDNIICGITSVSFSKSGRLLLAGY-DDFNCNVWDALK 301 +S ++ I V +S +LA D NVWD K Sbjct: 342 HSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSK 380 >3ODT-A nrPDB Length = 313 Score = 53.1 bits (126), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 37/131 (28%), Positives = 63/131 (48%), Gaps = 14/131 (10%) Query: 123 IYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTG 182 +YNL+ +V ++ ++ +N+ +T+S D T LW + + TF+G Sbjct: 135 VYNLQAHNASVWDAKVVS-----------FSENKFLTASADKTIKLW--QNDKVIKTFSG 181 Query: 183 HTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFA 242 DV+ D F+S + D KL D+ G +T+ GHES + I PNG+ + Sbjct: 182 IHNDVVRHLAVVDDGHFISCSNDGLIKLVDMHTGDVLRTYEGHESFVYCIKLLPNGDIVS 241 Query: 243 TGSDDATCRLF 253 G +D T R++ Sbjct: 242 CG-EDRTVRIW 251 Score = 45.1 bits (105), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 52/236 (22%), Positives = 94/236 (39%), Gaps = 11/236 (4%) Query: 37 IDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLR 96 IDP Q+ TL+GH + + DS++ S S+DG + +W + Sbjct: 2 IDPFTGYQLSA--TLKGHDQDVRDVVAVDDSKV-ASVSRDGTVRLWSKDDQWLGTVVYTG 58 Query: 97 SSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQ 156 ++ + Y + GG D + + L G + L GH G + C D Sbjct: 59 QGFLNSVCYDSEKELLLFGGKDTMINGVPLFATSGEDPL-YTLIGHQGNV-CSLSFQDGV 116 Query: 157 IVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTR-LFVSGACDASAKLWDVRE 215 +++ S D T +W + G H V + + F++ + D + KLW + Sbjct: 117 VISGSWDKTAKVW--KEGSLVYNLQAHNASVWDAKVVSFSENKFLTASADKTIKLW--QN 172 Query: 216 GMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYS-HDNII 270 +TF+G +D+ + F + S+D +L D+ L TY H++ + Sbjct: 173 DKVIKTFSGIHNDVVRHLAVVDDGHFISCSNDGLIKLVDMHTGDVLRTYEGHESFV 228 Score = 44.3 bits (103), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 33/123 (26%), Positives = 53/123 (43%), Gaps = 3/123 (2%) Query: 132 NVRVSRELAG-HTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSL 190 N +V + +G H + +DD ++ S D L D+ TG T+ GH V + Sbjct: 172 NDKVIKTFSGIHNDVVRHLAVVDDGHFISCSNDGLIKLVDMHTGDVLRTYEGHESFVYCI 231 Query: 191 SLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATC 250 L P+ + VS D + ++W G +Q T I ++ NG+ GS D Sbjct: 232 KLLPNGDI-VSCGEDRTVRIWSKENGSLKQVITLPAISIWSVDCMSNGDIIV-GSSDNLV 289 Query: 251 RLF 253 R+F Sbjct: 290 RIF 292 Score = 37.4 bits (85), Expect = 0.010, Method: Compositional matrix adjust. Identities = 58/255 (22%), Positives = 100/255 (39%), Gaps = 59/255 (23%) Query: 134 RVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWD---------IETGQ--------- 175 ++S L GH + +DD+++ + S D T LW + TGQ Sbjct: 9 QLSATLKGHDQDVRDVVAVDDSKVASVSRDGTVRLWSKDDQWLGTVVYTGQGFLNSVCYD 68 Query: 176 ---------------------------QTTTFTGHTGDVMSLSLAPDTRLFVSGACDASA 208 T GH G+V SLS + +SG+ D +A Sbjct: 69 SEKELLLFGGKDTMINGVPLFATSGEDPLYTLIGHQGNVCSLSFQDG--VVISGSWDKTA 126 Query: 209 KLWDVREGMCRQTFTGHESDI-NAICFFPNGNAFATGSDDATCRLFDLRADQELMTYS-- 265 K+W +EG H + + +A + N F T S D T +L+ + D+ + T+S Sbjct: 127 KVW--KEGSLVYNLQAHNASVWDAKVVSFSENKFLTASADKTIKLW--QNDKVIKTFSGI 182 Query: 266 HDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGM 325 H++++ + V G + D + D D GH++ V C+ + +G Sbjct: 183 HNDVVRHLAVVD---DGHFISCSNDGL-IKLVDMHTGDVLRTYEGHESFVYCIKLLPNGD 238 Query: 326 AVATGSWDSFLKIWN 340 V+ G D ++IW+ Sbjct: 239 IVSCGE-DRTVRIWS 252 Score = 36.2 bits (82), Expect = 0.019, Method: Compositional matrix adjust. Identities = 25/112 (22%), Positives = 48/112 (42%), Gaps = 6/112 (5%) Query: 70 LVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTR 129 ++AS D + +W + K + + + V A G++++C D + + ++ T Sbjct: 158 FLTASADKTIKLWQNDKVIKTFS-GIHNDVVRHLAVVDDGHFISCSN-DGLIKLVDMHTG 215 Query: 130 EGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFT 181 + V R GH ++ C + L + IV+ D T +W E G T Sbjct: 216 D----VLRTYEGHESFVYCIKLLPNGDIVSCGEDRTVRIWSKENGSLKQVIT 263 >3CFV-B nrPDB Length = 414 Score = 52.8 bits (125), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 47/159 (29%), Positives = 70/159 (44%), Gaps = 14/159 (8%) Query: 156 QIVTSSGDTTCALWDIETGQQ-------TTTFTGHTGDVMSLSLAP-DTRLFVSGACDAS 207 ++++S D T LWDI G + FTGH+ V ++ LF S A D Sbjct: 194 HLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESLFGSVADDQK 253 Query: 208 AKLWDVREGMCRQT---FTGHESDINAICFFPNGN-AFATGSDDATCRLFDLRADQELMT 263 +WD R + H +++N + F P ATGS D T L+DLR + +L Sbjct: 254 LMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLR-NLKLKL 312 Query: 264 YSHDNIICGITSVSFSKSGRLLLAGY-DDFNCNVWDALK 301 ++ ++ I V +S +LA D NVWD K Sbjct: 313 HTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSK 351 >5OQL-d nrPDB Length = 446 Score = 52.4 bits (124), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 55/245 (22%), Positives = 101/245 (41%), Gaps = 15/245 (6%) Query: 103 CAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSG 162 C S N +A G D + +++L TR+ + +A H + F +D ++++ + Sbjct: 73 CKDKNSLNCIASGSGDGVVKVWDLTTRDEE---TWRVAAHNNIVKGLTFTNDKKLLSCAT 129 Query: 163 DTTCALWDIETGQQTTTFTG---HTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCR 219 D LWD TT G SLS F + + ++WD+ Sbjct: 130 DG-IKLWDPYASPSNTTPIATWQEGGPYTSLSFHRSANTFAASSGQGCIRIWDLEHSTAG 188 Query: 220 QT--FTGHESDINAICFFP-NGNAFATGSDDATCRLFDLRADQELM-TYSHDNIICGITS 275 Q + I +CF + + + D + LFDLR + ++ T H C Sbjct: 189 QAIQWPSFVDTITDVCFNQVETSVIGSVATDRSIILFDLRTNMPVIKTVLH--FACNRIV 246 Query: 276 VSFSKSGRLLLAGYDDFNCNVWDALKADRA-GVLAGHDNRVSCLGVTDDGMAVATGSWDS 334 + ++ L +A +D N ++DA D+A + GH V + + G + +GS+D Sbjct: 247 FNPMEAMNLAVAS-EDHNIYIFDARNFDKALNIQKGHVAAVMDVEFSPTGEELVSGSYDR 305 Query: 335 FLKIW 339 +++W Sbjct: 306 TIRLW 310 Score = 41.6 bits (96), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 25/86 (29%), Positives = 40/86 (46%), Gaps = 1/86 (1%) Query: 224 GHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGR 283 GH + + + F P G +GS D T RL+ A Y H + + ++ + Sbjct: 281 GHVAAVMDVEFSPTGEELVSGSYDRTIRLWRRDAGHSRDVY-HTKRMQRVFRTMWTMDSK 339 Query: 284 LLLAGYDDFNCNVWDALKADRAGVLA 309 +L G DD N +W A ++R+GV A Sbjct: 340 YILTGSDDGNVRLWRANASERSGVKA 365 Score = 36.2 bits (82), Expect = 0.020, Method: Compositional matrix adjust. Identities = 22/79 (27%), Positives = 33/79 (41%), Gaps = 1/79 (1%) Query: 182 GHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTF-TGHESDINAICFFPNGNA 240 GH VM + +P VSG+ D + +LW G R + T + + + Sbjct: 281 GHVAAVMDVEFSPTGEELVSGSYDRTIRLWRRDAGHSRDVYHTKRMQRVFRTMWTMDSKY 340 Query: 241 FATGSDDATCRLFDLRADQ 259 TGSDD RL+ A + Sbjct: 341 ILTGSDDGNVRLWRANASE 359 Score = 28.9 bits (63), Expect = 3.0, Method: Compositional matrix adjust. Identities = 17/67 (25%), Positives = 30/67 (44%), Gaps = 9/67 (13%) Query: 52 RGHLAKIYAMHWGTDSRLLVSASQDGKLIIW--------DSYTTNKVHAIPLRSSWVMTC 103 +GH+A + + + LVS S D + +W D Y T ++ + R+ W M Sbjct: 280 KGHVAAVMDVEFSPTGEELVSGSYDRTIRLWRRDAGHSRDVYHTKRMQRV-FRTMWTMDS 338 Query: 104 AYAPSGN 110 Y +G+ Sbjct: 339 KYILTGS 345 >3C9C-A nrPDB Length = 432 Score = 51.2 bits (121), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 53/225 (23%), Positives = 89/225 (39%), Gaps = 46/225 (20%) Query: 38 DPVGRIQMRTRRTLRGHLAKIYAMHWGTD-SRLLVSASQDGKLIIWDSYTTNKVHAIPLR 96 +P G Q R LRGH + Y + W + + L+SAS D + +WD T K H Sbjct: 168 EPSGECQPDLR--LRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEH----- 220 Query: 97 SSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQ 156 + N+ T G+ V ++A H L ++ Sbjct: 221 ----------------------RVIDAKNIFT--GHTAVVEDVAWH--------LLHESL 248 Query: 157 IVTSSGDTTCALWDIE---TGQQTTTFTGHTGDVMSLSLAPDTR-LFVSGACDASAKLWD 212 + + D +WD T + + T HT +V LS P + + +G+ D + LWD Sbjct: 249 FGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 308 Query: 213 VREGMCR-QTFTGHESDINAICFFP-NGNAFATGSDDATCRLFDL 255 +R + +F H+ +I + + P N A+ D ++DL Sbjct: 309 LRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDL 353 Score = 51.2 bits (121), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 48/158 (30%), Positives = 69/158 (43%), Gaps = 14/158 (8%) Query: 157 IVTSSGDTTCALWDIETGQQ-------TTTFTGHTGDVMSLSLAP-DTRLFVSGACDASA 208 ++++S D T LWDI + FTGHT V ++ LF S A D Sbjct: 199 LLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKL 258 Query: 209 KLWDVREG---MCRQTFTGHESDINAICFFPNGN-AFATGSDDATCRLFDLRADQELMTY 264 +WD R T H +++N + F P ATGS D T L+DLR + +L + Sbjct: 259 MIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLR-NLKLKLH 317 Query: 265 SHDNIICGITSVSFSKSGRLLLAGY-DDFNCNVWDALK 301 S ++ I V +S +LA D +VWD K Sbjct: 318 SFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSK 355 >5WLC-LU nrPDB Length = 489 Score = 48.9 bits (115), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 39/159 (24%), Positives = 71/159 (44%), Gaps = 7/159 (4%) Query: 153 DDNQIVTSSG-DTTCALWDIETGQQTTTFTGHTGDVMSLSLAP-DTRLFVSGACDASAKL 210 ++ I+ S+G D + L+D+ T T T ++ P + FV+ D +A Sbjct: 230 NETDILASTGSDNSIVLYDLRTNSPTQKIV-QTMRTNAICWNPMEAFNFVTANEDHNAYY 288 Query: 211 WDVREGMCR--QTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDN 268 +D+R + R F H S + + F P G+ TGS D + R++ Y H Sbjct: 289 YDMR-NLSRSLNVFKDHVSAVMDVDFSPTGDEIVTGSYDKSIRIYKTNHGHSREIY-HTK 346 Query: 269 IICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGV 307 + + V +S + +++G DD N +W + +R+ V Sbjct: 347 RMQHVFQVKYSMDSKYIISGSDDGNVRLWRSKAWERSNV 385 Score = 45.8 bits (107), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 63/272 (23%), Positives = 104/272 (38%), Gaps = 45/272 (16%) Query: 104 AYAPSGNY-----VACGGLDNICSIYNLKTREGNVRVSRELAGHTGY-LSCCRFLD---- 153 YA + NY +A G D + +N+ TRE V TG ++ RF D Sbjct: 70 VYAIAKNYGSLNKLATGSADGVIKYWNMSTREEFVSFKAHYGLVTGLCVTQPRFHDKKPD 129 Query: 154 ---DNQIVTSSGDTTCALWDIETGQQTT-----------------TFTGHTGDVMSLSLA 193 N +++ S D T LW I + TF G + + Sbjct: 130 LKSQNFMLSCSDDKTVKLWSINVDDYSNKNSSDNDSVTNEEGLIRTFDGESA-FQGIDSH 188 Query: 194 PDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAF--ATGSDDATCR 251 + F +G A LWDV + +I ++ F N +TGSD++ Sbjct: 189 RENSTFATGG--AKIHLWDVNRLKPVSDLSWGADNITSLKFNQNETDILASTGSDNSIV- 245 Query: 252 LFDLRAD---QELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRA-GV 307 L+DLR + Q+++ N IC +F+ + +D N +D R+ V Sbjct: 246 LYDLRTNSPTQKIVQTMRTNAICWNPMEAFN-----FVTANEDHNAYYYDMRNLSRSLNV 300 Query: 308 LAGHDNRVSCLGVTDDGMAVATGSWDSFLKIW 339 H + V + + G + TGS+D ++I+ Sbjct: 301 FKDHVSAVMDVDFSPTGDEIVTGSYDKSIRIY 332 Score = 32.0 bits (71), Expect = 0.41, Method: Compositional matrix adjust. Identities = 23/101 (22%), Positives = 40/101 (39%), Gaps = 3/101 (2%) Query: 70 LVSASQDGKLIIWDSYTTNK-VHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKT 128 V+A++D +D ++ ++ S VM ++P+G+ + G D IY KT Sbjct: 277 FVTANEDHNAYYYDMRNLSRSLNVFKDHVSAVMDVDFSPTGDEIVTGSYDKSIRIY--KT 334 Query: 129 REGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALW 169 G+ R +D I++ S D LW Sbjct: 335 NHGHSREIYHTKRMQHVFQVKYSMDSKYIISGSDDGNVRLW 375 >4L9O-A nrPDB Length = 349 Score = 47.8 bits (112), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 62/276 (22%), Positives = 100/276 (36%), Gaps = 68/276 (24%) Query: 45 MRTRRTLRGHLAKIYAMHWGTDS--RLLVSASQDGKLIIW--DSYTTNKVHAIPLRSSWV 100 R TL GH ++ + W +L S S DGK++IW D+ NKV + + V Sbjct: 103 QRLVETLIGHEGPVWQVAWAHPKFGVILASCSYDGKVLIWKEDNGVWNKVAEHSVHQASV 162 Query: 101 MTCAYAPS--GNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIV 158 + ++AP G + C D G +S F D + Sbjct: 163 NSVSWAPHEYGPVLLCASSD-------------------------GKISIVEFKDGGAL- 196 Query: 159 TSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAP-----DTRLFVSGACDASAKLWDV 213 + GH V + S AP +TR FVSG CD K+W Sbjct: 197 -----------------EPIVIQGHAIGVNAASWAPISLPDNTRRFVSGGCDNLVKIWRY 239 Query: 214 REG----MCRQTFTGHESDINAICFFP---NGNAFATGSDDATCRLFDL-----RADQEL 261 + + + F GH + + + P + + AT S D T ++ + +++ Sbjct: 240 DDAAKTFIEEEAFQGHSDWVRDVAWSPSRLSKSYIATASQDRTVLIWTKDGKSNKWEKQP 299 Query: 262 MTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVW 297 +T +C S+S SG +L D +W Sbjct: 300 LTKEKFPDVC--WRASWSLSGNVLAISGGDNKVTLW 333 >2HES-X nrPDB Length = 330 Score = 47.8 bits (112), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 49/228 (21%), Positives = 97/228 (42%), Gaps = 18/228 (7%) Query: 49 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKL----IIWDSYTTNKVHAIPLRSSWVMTCA 104 ++L+ + KI++ + +L + S D K+ + +D +T V + + A Sbjct: 8 KSLKLYKEKIWSFDFS--QGILATGSTDRKIKLVSVKYDDFTLIDVLDETAHKKAIRSVA 65 Query: 105 YAPSGNYVACGGLDNICSIYNLKT---REGNVRVSRELAGHTGYLSCCRFLDDNQ-IVTS 160 + P + +A G D+ SI+ + R + + + GH + + +D + T Sbjct: 66 WRPHTSLLAAGSFDSTVSIWAKEESADRTFEMDLLAIIEGHENEVKGVAWSNDGYYLATC 125 Query: 161 SGDTTCALWDI-ETGQQ---TTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREG 216 S D + +W+ E+G++ + H+ DV + P L S + D + ++W + Sbjct: 126 SRDKSVWIWETDESGEEYECISVLQEHSQDVKHVIWHPSEALLASSSYDDTVRIWKDYDD 185 Query: 217 --MCRQTFTGHESDINAICFFPNGNAFA--TGSDDATCRLFDLRADQE 260 C GHE + + F F +GSDD+T R++ D E Sbjct: 186 DWECVAVLNGHEGTVWSSDFDKTEGVFRLCSGSDDSTVRVWKYMGDDE 233 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 43/179 (24%), Positives = 75/179 (41%), Gaps = 25/179 (13%) Query: 181 TGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTF--------TGHESDINAI 232 T H + S++ P T L +G+ D++ +W +E +TF GHE+++ + Sbjct: 55 TAHKKAIRSVAWRPHTSLLAAGSFDSTVSIW-AKEESADRTFEMDLLAIIEGHENEVKGV 113 Query: 233 CFFPNGNAFATGSDDATCRLFDLRADQE-------LMTYSHDNIICGITSVSFSKSGRLL 285 + +G AT S D + +++ E L +S D + V + S LL Sbjct: 114 AWSNDGYYLATCSRDKSVWIWETDESGEEYECISVLQEHSQD-----VKHVIWHPSEALL 168 Query: 286 LAGYDDFNCNVWDALKADR--AGVLAGHDNRV--SCLGVTDDGMAVATGSWDSFLKIWN 340 + D +W D VL GH+ V S T+ + +GS DS +++W Sbjct: 169 ASSSYDDTVRIWKDYDDDWECVAVLNGHEGTVWSSDFDKTEGVFRLCSGSDDSTVRVWK 227 Score = 37.0 bits (84), Expect = 0.011, Method: Compositional matrix adjust. Identities = 32/115 (27%), Positives = 49/115 (42%), Gaps = 10/115 (8%) Query: 235 FPNGNAFATGSDDATCRLFDLRADQELMTYSHDNII--CGITSVSFSKSGRLLLAGYDDF 292 F G ATGS D +L ++ D + D I SV++ LL AG D Sbjct: 22 FSQG-ILATGSTDRKIKLVSVKYDDFTLIDVLDETAHKKAIRSVAWRPHTSLLAAGSFDS 80 Query: 293 NCNVW-------DALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 ++W + D ++ GH+N V + ++DG +AT S D + IW Sbjct: 81 TVSIWAKEESADRTFEMDLLAIIEGHENEVKGVAWSNDGYYLATCSRDKSVWIWE 135 Score = 34.3 bits (77), Expect = 0.075, Method: Compositional matrix adjust. Identities = 50/241 (20%), Positives = 87/241 (36%), Gaps = 35/241 (14%) Query: 43 IQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNK----VHAIPLRSS 98 +M + GH ++ + W D L + S+D + IW++ + + + + S Sbjct: 95 FEMDLLAIIEGHENEVKGVAWSNDGYYLATCSRDKSVWIWETDESGEEYECISVLQEHSQ 154 Query: 99 WVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDN--- 155 V + PS +A D+ I+ K + + L GH G + F Sbjct: 155 DVKHVIWHPSEALLASSSYDDTVRIW--KDYDDDWECVAVLNGHEGTVWSSDFDKTEGVF 212 Query: 156 QIVTSSGDTTCALW----DIETGQQTTTFTGHTGDV--------------MSLSLAPDTR 197 ++ + S D+T +W D E QQ DV + S+ D Sbjct: 213 RLCSGSDDSTVRVWKYMGDDEDDQQEWVCEAILPDVHKRQVYNVAWGFNGLIASVGADGV 272 Query: 198 LFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFP-NGNA-FATGSDDATCRLFDL 255 L V D K++ + +C + +IN + + NG ATG DD + L Sbjct: 273 LAVYEEVDGEWKVF-AKRALCHGVY-----EINVVKWLELNGKTILATGGDDGIVNFWSL 326 Query: 256 R 256 Sbjct: 327 E 327 >4XFV-A nrPDB Length = 792 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 66/285 (23%), Positives = 110/285 (38%), Gaps = 39/285 (13%) Query: 38 DPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIW---DSYTTNKVHAIP 94 DP+ TL+GH A++ + + DS +VSAS+D + IW D + I Sbjct: 46 DPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQ 105 Query: 95 LRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGY-----LSCC 149 S ++ + PS V C D SI+ + ++ E G+ LS Sbjct: 106 HYSKTIVALSALPSLISVGCA--DGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLS 163 Query: 150 RFLDDNQIVTSSGDTTCALW---------DIETGQQTTTFTGHTGDVMSLSL----APDT 196 + +++ + + + G T ++ IE + GH V SL+ P Sbjct: 164 K-VEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGD 222 Query: 197 RLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLR 256 L SG+ D +LW +R E D + N + DD +LR Sbjct: 223 YLLCSGSQDRYIRLWRIR---INDLIDDSEEDSKKLTLLSN-KQYKFQIDD------ELR 272 Query: 257 A--DQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDA 299 + E + HD+ I+S+ + +S LLA D + VW+ Sbjct: 273 VGINFEALIMGHDD---WISSLQWHESRLQLLAATADTSLMVWEP 314 Score = 33.1 bits (74), Expect = 0.17, Method: Compositional matrix adjust. Identities = 28/136 (20%), Positives = 58/136 (42%), Gaps = 21/136 (15%) Query: 139 LAGHTGYLSCCRFLDDN-QIVTSSGDTTCALWDIE---------------TGQQTTTFTG 182 + GH ++S ++ + Q++ ++ DT+ +W+ + + + +T TG Sbjct: 281 IMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATG 340 Query: 183 HTGDVMSLSLAPDTRL--FVSGACDASAKLWDVREGMC---RQTFTGHESDINAICFFPN 237 +G S R+ F++ S ++W ++ + R +G D+ I + P+ Sbjct: 341 SSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPS 400 Query: 238 GNAFATGSDDATCRLF 253 G S D T RLF Sbjct: 401 GEYLLATSLDQTTRLF 416 Score = 32.7 bits (73), Expect = 0.20, Method: Compositional matrix adjust. Identities = 15/48 (31%), Positives = 25/48 (52%), Gaps = 3/48 (6%) Query: 296 VWDALKADRAGV---LAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 +WD ++ + GV L GH+ V+C+ D + + S D +KIW Sbjct: 44 LWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWK 91 Score = 29.3 bits (64), Expect = 2.4, Method: Compositional matrix adjust. Identities = 26/109 (23%), Positives = 47/109 (43%), Gaps = 7/109 (6%) Query: 13 QLKNQIRDARKACADATL---SQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRL 69 ++ + I D+ + TL Q ID R+ + + GH I ++ W Sbjct: 240 RINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQ 299 Query: 70 LVSASQDGKLIIWDSYTTNKVHAIPLR----SSWVMTCAYAPSGNYVAC 114 L++A+ D L++W+ T+ + LR SS + A SG + +C Sbjct: 300 LLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSC 348 >5M89-A nrPDB Length = 329 Score = 46.6 bits (109), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 45/198 (22%), Positives = 84/198 (42%), Gaps = 15/198 (7%) Query: 113 ACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIE 172 A GGLD IY++ +V R L G ++V + ++D Sbjct: 67 AVGGLDGKLDIYSVVAN----KVERTL--DIGEPVTATEWTGTKVVIGTAKGWVKVYD-- 118 Query: 173 TGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGH-ESDINA 231 G+++ TF H G V L++ P R+ S D S +D+ G + G+ ++ + Sbjct: 119 AGRESATFQTHAGPVTGLAVHPGGRILASVGVDKSFVFYDLETG--ERVARGYADAALTT 176 Query: 232 ICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLA-GYD 290 F P+GN FA G+ +F ++ ++ + I +++FS++G A G Sbjct: 177 CAFHPDGNLFAAGTQTGHILVFHTTTLEQAESFP---LGTPIQALAFSENGFWFAATGKG 233 Query: 291 DFNCNVWDALKADRAGVL 308 + ++D K+ A + Sbjct: 234 TSSVTIFDLRKSGAAAAV 251 Score = 31.2 bits (69), Expect = 0.60, Method: Compositional matrix adjust. Identities = 21/85 (24%), Positives = 34/85 (40%), Gaps = 1/85 (1%) Query: 46 RTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAY 105 R T + H + + R+L S D + +D T +V A + + TCA+ Sbjct: 121 RESATFQTHAGPVTGLAVHPGGRILASVGVDKSFVFYDLETGERV-ARGYADAALTTCAF 179 Query: 106 APSGNYVACGGLDNICSIYNLKTRE 130 P GN A G +++ T E Sbjct: 180 HPDGNLFAAGTQTGHILVFHTTTLE 204 >3ACP-A nrPDB Length = 417 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 40/177 (22%), Positives = 73/177 (41%), Gaps = 9/177 (5%) Query: 105 YAPSGNYVACGGLDNICSIYNLKTREGNVRVSRE--LAGHTGYLSCCRFLDDNQIVTSSG 162 + G+++ LD ++N R+G+ + R A T L RF+ + T+ G Sbjct: 61 FEKVGSHLYKARLDGHDFLFNTIIRDGSKMLKRADYTAVDTAKLQMRRFI----LGTTEG 116 Query: 163 DTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTF 222 D + D Q H ++ L P +S + D K+W V++G +T Sbjct: 117 D--IKVLDSNFNLQREIDQAHVSEITKLKFFPSGEALISSSQDMQLKIWSVKDGSNPRTL 174 Query: 223 TGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSH-DNIICGITSVSF 278 GH + + I G + S D T RL++ + T++ +N G+ S++ Sbjct: 175 IGHRATVTDIAIIDRGRNVLSASLDGTIRLWECGTGTTIHTFNRKENPHDGVNSIAL 231 Score = 38.9 bits (89), Expect = 0.004, Method: Compositional matrix adjust. Identities = 18/70 (25%), Positives = 30/70 (42%) Query: 270 ICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVAT 329 + IT + F SG L++ D +W L GH V+ + + D G V + Sbjct: 136 VSEITKLKFFPSGEALISSSQDMQLKIWSVKDGSNPRTLIGHRATVTDIAIIDRGRNVLS 195 Query: 330 GSWDSFLKIW 339 S D +++W Sbjct: 196 ASLDGTIRLW 205 Score = 35.4 bits (80), Expect = 0.038, Method: Compositional matrix adjust. Identities = 54/261 (20%), Positives = 96/261 (36%), Gaps = 49/261 (18%) Query: 49 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAI--------------- 93 RTL GH A + + R ++SAS DG + +W+ T +H Sbjct: 172 RTLIGHRATVTDIAIIDRGRNVLSASLDGTIRLWECGTGTTIHTFNRKENPHDGVNSIAL 231 Query: 94 ---------PLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTG 144 + +S + G YV G + + +++N+ ++E +++ + Sbjct: 232 FVGTDRQLHEISTSKKNNLEFGTYGKYVIAGHVSGVITVHNVFSKEQTIQLPSKFT---- 287 Query: 145 YLSCCRFLDD----NQIVTSSGDTTCALWDIETGQ-QTTTFTGHTGDVMSLSLAPDTRLF 199 SC D N I + A WD+ + + F + G ++ LF Sbjct: 288 -CSCNSLTVDGNNANYIYAGYENGMLAQWDLRSPECPVGEFLINEGTPINNVYFAAGALF 346 Query: 200 VSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDAT---CRLFDLR 256 VS D S KL + ES+ AI F F +DD C + D Sbjct: 347 VSSGFDTSIKL---------DIISDPESERPAIEF--ETPTFLVSNDDEVSQFCYVSDDE 395 Query: 257 ADQELMTYSHDNIICGITSVS 277 ++ E++ +N C + ++S Sbjct: 396 SNGEVLEVGKNN-FCALYNLS 415 Score = 27.3 bits (59), Expect = 9.5, Method: Compositional matrix adjust. Identities = 23/105 (21%), Positives = 40/105 (38%) Query: 48 RRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAP 107 R + H+++I + + L+S+SQD +L IW + + + V A Sbjct: 129 REIDQAHVSEITKLKFFPSGEALISSSQDMQLKIWSVKDGSNPRTLIGHRATVTDIAIID 188 Query: 108 SGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFL 152 G V LD ++ T +R+ H G S F+ Sbjct: 189 RGRNVLSASLDGTIRLWECGTGTTIHTFNRKENPHDGVNSIALFV 233 >4OWR-A nrPDB Length = 339 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 30/116 (25%), Positives = 52/116 (44%), Gaps = 5/116 (4%) Query: 152 LDDNQIVTSSGDTTCALWDIETGQQTTTFTG--HTGDVMSLSLAPDTRLFVSGACDASAK 209 L N ++ S W+++ QT HTG V+ + + D + +CD +AK Sbjct: 23 LPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAK 82 Query: 210 LWDVREGMCRQTFTGHESDINAICFF--PNGNAFATGSDDATCRLFDLRADQELMT 263 +WD+ Q H++ + I + PN + TGS D T + +D R+ +M Sbjct: 83 MWDLSSNQAIQ-IAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWDTRSSNPMMV 137 Score = 35.4 bits (80), Expect = 0.033, Method: Compositional matrix adjust. Identities = 35/149 (23%), Positives = 63/149 (42%), Gaps = 13/149 (8%) Query: 190 LSLAPDT---RLFVSGACDASAKLWDVREG-----MCRQTFTGHESDINAICFFPNGNAF 241 LS +P T ++G+ + W+V++ +Q TG D+ C+ +G+ Sbjct: 16 LSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDV---CWSDDGSKV 72 Query: 242 ATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALK 301 T S D T +++DL ++Q + HD + I + + + ++ G D WD Sbjct: 73 FTASCDKTAKMWDLSSNQAIQIAQHDAPVKTIHWIK-APNYSCVMTGSWDKTLKFWDTRS 131 Query: 302 ADRAGVLAGHDNRVSCLGVTDDGMAVATG 330 ++ VL + R C V VAT Sbjct: 132 SNPMMVLQLPE-RCYCADVIYPMAVVATA 159 Score = 32.3 bits (72), Expect = 0.33, Method: Compositional matrix adjust. Identities = 26/105 (24%), Positives = 44/105 (41%), Gaps = 3/105 (2%) Query: 238 GNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVW 297 GN GS R ++++ + + + + V +S G + D +W Sbjct: 25 GNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMW 84 Query: 298 DALKADRAGVLAGHDNRVSCLG--VTDDGMAVATGSWDSFLKIWN 340 D L +++A +A HD V + + V TGSWD LK W+ Sbjct: 85 D-LSSNQAIQIAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWD 128 >5WYJ-BE nrPDB Length = 939 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 40/187 (21%), Positives = 78/187 (41%), Gaps = 6/187 (3%) Query: 157 IVTSSGDTTCA-LWDIETGQ--QTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDV 213 I+T+ D A WD+ + + T T G V S++++ G+ + S ++++ Sbjct: 430 IITAHKDEKFARTWDMRNKRVGRWTFDTTDDGFVKSVAMSQCGNFGFIGSSNGSITIYNM 489 Query: 214 REGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGI 273 + G+ R+ + H+ + I + D +D L D I Sbjct: 490 QSGILRKKYKLHKRAVTGISLDGMNRKMVSCGLDGIVGFYDFNKSTLLGKLKLD---API 546 Query: 274 TSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWD 333 T++ + +S L DD + V DA+ L GH NR++ + +G + + S D Sbjct: 547 TAMVYHRSSDLFALALDDLSIVVIDAVTQRVVRQLWGHSNRITAFDFSPEGRWIVSASLD 606 Query: 334 SFLKIWN 340 S ++ W+ Sbjct: 607 STIRTWD 613 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 37/137 (27%), Positives = 57/137 (41%), Gaps = 16/137 (11%) Query: 112 VACGGLDNICSIY--NLKTREGNVRVSRELAGHTGYLSCCRF---LDDNQIVTSSGDTTC 166 V+CG LD I Y N T G +++ + + S F LDD IV Sbjct: 518 VSCG-LDGIVGFYDFNKSTLLGKLKLDAPITAMVYHRSSDLFALALDDLSIV-------- 568 Query: 167 ALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHE 226 + D T + GH+ + + +P+ R VS + D++ + WD+ G C Sbjct: 569 -VIDAVTQRVVRQLWGHSNRITAFDFSPEGRWIVSASLDSTIRTWDLPTGGCIDGIIVDN 627 Query: 227 SDINAICFFPNGNAFAT 243 N + F PNG+ AT Sbjct: 628 VATN-VKFSPNGDLLAT 643 Score = 33.9 bits (76), Expect = 0.092, Method: Compositional matrix adjust. Identities = 49/192 (25%), Positives = 82/192 (42%), Gaps = 17/192 (8%) Query: 99 WVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIV 158 +V + A + GN+ G + +IYN+++ G +R +L H ++ N+ + Sbjct: 462 FVKSVAMSQCGNFGFIGSSNGSITIYNMQS--GILRKKYKL--HKRAVTGISLDGMNRKM 517 Query: 159 TSSG-DTTCALWDIETGQQTTTFTGHT---GDVMSLSLAPDTRLFVSGACDASAKLWD-V 213 S G D +D +T G + ++ + LF D S + D V Sbjct: 518 VSCGLDGIVGFYDF----NKSTLLGKLKLDAPITAMVYHRSSDLFALALDDLSIVVIDAV 573 Query: 214 REGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGI 273 + + RQ + GH + I A F P G + S D+T R +DL + DN+ Sbjct: 574 TQRVVRQLW-GHSNRITAFDFSPEGRWIVSASLDSTIRTWDLPTGGCIDGIIVDNV---A 629 Query: 274 TSVSFSKSGRLL 285 T+V FS +G LL Sbjct: 630 TNVKFSPNGDLL 641 Score = 31.6 bits (70), Expect = 0.51, Method: Compositional matrix adjust. Identities = 20/72 (27%), Positives = 34/72 (47%), Gaps = 1/72 (1%) Query: 43 IQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMT 102 + R R L GH +I A + + R +VSAS D + WD T + I + + Sbjct: 573 VTQRVVRQLWGHSNRITAFDFSPEGRWIVSASLDSTIRTWDLPTGGCIDGI-IVDNVATN 631 Query: 103 CAYAPSGNYVAC 114 ++P+G+ +A Sbjct: 632 VKFSPNGDLLAT 643 Score = 31.6 bits (70), Expect = 0.58, Method: Compositional matrix adjust. Identities = 22/84 (26%), Positives = 38/84 (45%), Gaps = 3/84 (3%) Query: 48 RRTLRGHL---AKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCA 104 + TL G L A I AM + S L A D +++ D+ T V + S+ + Sbjct: 533 KSTLLGKLKLDAPITAMVYHRSSDLFALALDDLSIVVIDAVTQRVVRQLWGHSNRITAFD 592 Query: 105 YAPSGNYVACGGLDNICSIYNLKT 128 ++P G ++ LD+ ++L T Sbjct: 593 FSPEGRWIVSASLDSTIRTWDLPT 616 >5K0Y-T nrPDB Length = 329 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 46/212 (21%), Positives = 89/212 (41%), Gaps = 11/212 (5%) Query: 139 LAGHTGYLSCCRF-LDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTR 197 L GH ++ ++ + + + T + D +W G++ T+ GHTG V + DT+ Sbjct: 6 LQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTK 65 Query: 198 LFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDAT-----CRL 252 ++G+ D S +LWD G + S + F GN +D Sbjct: 66 HVLTGSADNSCRLWDCETGK-QLALLKTNSAVRTCGFDFGGNIIMFSTDKQMGYQCFVSF 124 Query: 253 FDLRADQEL-MTYSHDNIICG---ITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVL 308 FDLR ++ + I C ITS + G ++AG++ N + A + + Sbjct: 125 FDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGEVLVNV 184 Query: 309 AGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 H +++ + ++ + T S D+ K+++ Sbjct: 185 KEHSRQINDIQLSREMTMFVTASKDNTAKLFD 216 Score = 42.0 bits (97), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 40/174 (22%), Positives = 70/174 (40%), Gaps = 18/174 (10%) Query: 93 IPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFL 152 IP S + + + P G + G + Y+ K+ E V V +E + + R + Sbjct: 142 IPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGEVLVNV-KEHSRQINDIQLSREM 200 Query: 153 DDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLW- 211 VT+S D T L+D T + TF ++ +L+P+ V G + + Sbjct: 201 --TMFVTASKDNTAKLFDSTTLEHQKTFRTEPPRELA-ALSPNYEHVVVGGGQEAMDVTT 257 Query: 212 -DVREGMCRQTF------------TGHESDINAICFFPNGNAFATGSDDATCRL 252 R G F GH IN++ F P+G ++++G +D R+ Sbjct: 258 TSTRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHPDGKSYSSGGEDGYVRI 311 Score = 33.1 bits (74), Expect = 0.16, Method: Compositional matrix adjust. Identities = 58/305 (19%), Positives = 115/305 (37%), Gaps = 56/305 (18%) Query: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109 T GH ++ + D++ +++ S D +WD T ++ A+ +S V TC + G Sbjct: 47 TYMGHTGAVWCVDADWDTKHVLTGSADNSCRLWDCETGKQL-ALLKTNSAVRTCGFDFGG 105 Query: 110 NYVACG-----GLDNICSIYNLK------TREGNVRV----SRELAGHTGYLSCCRFLDD 154 N + G S ++L+ E +++ S+ + G L C Sbjct: 106 NIIMFSTDKQMGYQCFVSFFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGEC----- 160 Query: 155 NQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVR 214 I+ + ++G+ H+ + + L+ + +FV+ + D +AKL+D Sbjct: 161 --IIAGHESGELNQYSAKSGEVLVNVKEHSRQINDIQLSREMTMFVTASKDNTAKLFDST 218 Query: 215 EGMCRQTF-TGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGI 273 ++TF T ++ A+ PN G QE M + + G Sbjct: 219 TLEHQKTFRTEPPRELAALS--PNYEHVVVG------------GGQEAMDVTTTSTRIGK 264 Query: 274 TSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWD 333 F LA ++F G + GH ++ + DG + ++G D Sbjct: 265 FEARF-----FHLAFEEEF-------------GRVKGHFGPINSVAFHPDGKSYSSGGED 306 Query: 334 SFLKI 338 +++I Sbjct: 307 GYVRI 311 >5WJC-A nrPDB Length = 430 Score = 45.8 bits (107), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 61/237 (25%), Positives = 93/237 (39%), Gaps = 38/237 (16%) Query: 139 LAGHT--GYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTG----------HTGD 186 L GHT G+ C + T + D LWD++T T++ T HT Sbjct: 178 LKGHTAEGFGLCWNPNLPGNLATGAEDQVICLWDVQTQSFTSSETKVISPIAKYHRHTDI 237 Query: 187 VMSLSLAPDTR-LFVSGACDASAKLWDVR---EGMCRQTFTGHESDINAICFFP-NGNAF 241 V + P L S + D + ++ D R E + H INA+ P N Sbjct: 238 VNDVQFHPQHEALLASVSDDCTLQIHDTRLNPEEEAPKVIQAHSKAINAVAINPFNDYLL 297 Query: 242 ATGSDDATCRLFDLRAD-QELMTYS-HDNIICGITSVSFSKSGRLLLAGYD-DFNCNVWD 298 AT S D T L+DLR Q L T H++ + G+ +S +LA D +WD Sbjct: 298 ATASADKTVALWDLRNPYQRLHTLEGHEDEVYGL---EWSPHDEPILASSSTDRRVCIWD 354 Query: 299 ALK--------------ADRAGVLAGHDNRVSCLG-VTDDGMAVATGSWDSFLKIWN 340 K + + GH NR+S ++ V + + D+ L+IW+ Sbjct: 355 LEKIGEEQTPEDAEDGSPELLFMHGGHTNRISEFSWCPNERWVVGSLADDNILQIWS 411 Score = 32.7 bits (73), Expect = 0.22, Method: Compositional matrix adjust. Identities = 14/36 (38%), Positives = 21/36 (58%), Gaps = 1/36 (2%) Query: 49 RTLRGHLAKIYAMHWGT-DSRLLVSASQDGKLIIWD 83 TL GH ++Y + W D +L S+S D ++ IWD Sbjct: 319 HTLEGHEDEVYGLEWSPHDEPILASSSTDRRVCIWD 354 >4XYI-A nrPDB Length = 430 Score = 45.8 bits (107), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 61/241 (25%), Positives = 94/241 (39%), Gaps = 46/241 (19%) Query: 143 TGYLSCCR------------FLDDNQIVTSSGDTTCALWDIETGQ----------QTTTF 180 TG+ +C R F+ + + T + DT+ +WDI+ + + Sbjct: 172 TGHQACLRHHTSEGFGLGWNFIQEGTLATGTEDTSICVWDIKGKSLSLEKSIDVAPVSVY 231 Query: 181 TGHTGDVMSLSLAPDTR-LFVSGACDASAKLWDVR---EGMCRQTFTGHESDINAICFFP 236 HT V L L S + D + ++ D R Q HE +N + F P Sbjct: 232 HRHTAVVNDLQFHLQHEALLTSVSDDCTLQIHDTRLPSSSSASQCVKAHEQPVNGVAFNP 291 Query: 237 -NGNAFATGSDDATCRLFDL-RADQELMTYS-HDNIICGITSVSFSKSGRLLLAGYDDFN 293 N AT S D T L+DL R +Q L T H++ + + + +L+ D Sbjct: 292 FNDYLLATASADHTVALWDLRRLNQRLHTLEGHEDEVYNVQWSPHDEP--ILVTSSTDRR 349 Query: 294 CNVWDALK----------ADRAGVL----AGHDNRVSCLG-VTDDGMAVATGSWDSFLKI 338 VWD K D A L GH NRVS L ++ +A+ + D+ L+I Sbjct: 350 VCVWDLSKIGEEQTVEDSEDGAPELMFMHGGHTNRVSDLSWNPNNKWVLASLADDNILQI 409 Query: 339 W 339 W Sbjct: 410 W 410 >5A9Q-2 nrPDB Length = 326 Score = 45.4 bits (106), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 49/182 (26%), Positives = 80/182 (43%), Gaps = 25/182 (13%) Query: 170 DIETGQQTTTFTGHTG-DVMSLSLAPDTRL--------FVSGACDASAKLW--DVREGMC 218 D+E Q T T H G V ++ +P+TRL F + A D +L+ D+++ Sbjct: 57 DVEGIQYKTLRTFHHGVRVDGIAWSPETRLDSLPPVIKFCTSAADMKIRLFTSDLQDKNE 116 Query: 219 RQTFTGHESDINAICFFPN-GNAFATGSDDATCRLFDLRADQ--ELMTYSHDNIICGITS 275 + GH IN + F P G A+ SDD TCR+++L Q + +S +C Sbjct: 117 YKVLEGHTDFINGLVFDPKEGQEIASVSDDHTCRIWNLEGVQTAHFVLHSPGMSVCWHPE 176 Query: 276 VSF-----SKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATG 330 +F K+G + YD +L++++ +++ H CL T AVA Sbjct: 177 ETFKLMVAEKNGTIRF--YDLLAQQAILSLESEQVPLMSAH----WCLKNTFKVGAVAGN 230 Query: 331 SW 332 W Sbjct: 231 DW 232 Score = 32.0 bits (71), Expect = 0.43, Method: Compositional matrix adjust. Identities = 20/61 (32%), Positives = 33/61 (54%), Gaps = 4/61 (6%) Query: 137 RELAGHTGYLSCCRF--LDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAP 194 + L GHT +++ F + +I + S D TC +W++E G QT F H+ MS+ P Sbjct: 118 KVLEGHTDFINGLVFDPKEGQEIASVSDDHTCRIWNLE-GVQTAHFVLHSPG-MSVCWHP 175 Query: 195 D 195 + Sbjct: 176 E 176 >3BG0-A nrPDB Length = 316 Score = 45.4 bits (106), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 73/286 (25%), Positives = 110/286 (38%), Gaps = 49/286 (17%) Query: 51 LRGHLAKIYAMHWGTD--SRLLVSASQDGKLIIW--DSYTTNKVHAIPLRSSWVMTCAYA 106 LRGH ++ + W +L S S D K+IIW ++ T K H S V + +A Sbjct: 53 LRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWA 112 Query: 107 PS--GNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDT 164 P G +ACG D S+ T EG V + HT + C N + + Sbjct: 113 PHDYGLILACGSSDGAISLLTY-TGEGQWEVKKINNAHT--IGC------NAVSWAPAVV 163 Query: 165 TCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVRE-GMCRQTFT 223 +L D +GQ+ + F SG CD KLW E G ++ Sbjct: 164 PGSLIDHPSGQKPNYI----------------KRFASGGCDNLIKLWKEEEDGQWKE--- 204 Query: 224 GHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGR 283 E + A + A+A T + D + ++ D+ + S + S + Sbjct: 205 --EQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDD------ASSNTWSPK 256 Query: 284 LLLAGYDDFNCNVWDALKADRAGVLA--GHDNRVSCLGVTDDGMAV 327 LL FN VW + A +LA G DN+V+ + DG V Sbjct: 257 LL----HKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWV 298 Score = 28.1 bits (61), Expect = 5.1, Method: Compositional matrix adjust. Identities = 29/123 (23%), Positives = 54/123 (43%), Gaps = 8/123 (6%) Query: 223 TGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTY---SHDNIICGITSVSFS 279 T HE I+ G AT S D + ++FD+R +++ H+ + + + + Sbjct: 10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQV-AWAHP 68 Query: 280 KSGRLLLAGYDDFNCNVWDALKA--DRAGVLAGHDNRVS--CLGVTDDGMAVATGSWDSF 335 G +L + D +W +++ AGHD+ V+ C D G+ +A GS D Sbjct: 69 MYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGA 128 Query: 336 LKI 338 + + Sbjct: 129 ISL 131 >2PM9-A nrPDB Length = 416 Score = 45.1 bits (105), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 20/78 (25%), Positives = 38/78 (48%), Gaps = 2/78 (2%) Query: 52 RGHLAKIYAMHW-GTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSG- 109 +GH I ++ W D LL+S+ +D +++W+ + ++ P R +W +AP Sbjct: 259 QGHQKGILSLDWCHQDEHLLLSSGRDNTVLLWNPESAEQLSQFPARGNWCFKTKFAPEAP 318 Query: 110 NYVACGGLDNICSIYNLK 127 + AC DN + L+ Sbjct: 319 DLFACASFDNKIEVQTLQ 336 Score = 32.0 bits (71), Expect = 0.40, Method: Compositional matrix adjust. Identities = 28/93 (30%), Positives = 37/93 (39%), Gaps = 3/93 (3%) Query: 116 GLDNICSIYNLKTREGNVRVSRELAGH-TGYLSCCRFLDDNQIVTSSG-DTTCALWDIET 173 G DN SI R N + GH G LS D ++ SSG D T LW+ E+ Sbjct: 235 GSDNDPSILIWDLRNANTPLQTLNQGHQKGILSLDWCHQDEHLLLSSGRDNTVLLWNPES 294 Query: 174 GQQTTTFTGHTGDVMSLSLAPDTR-LFVSGACD 205 +Q + F AP+ LF + D Sbjct: 295 AEQLSQFPARGNWCFKTKFAPEAPDLFACASFD 327 >6ELZ-p nrPDB Length = 460 Score = 45.1 bits (105), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 29/136 (21%), Positives = 58/136 (42%), Gaps = 29/136 (21%) Query: 99 WVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIV 158 WV + ++ G D I ++L GNV+ ++ +GH+G + +++ + ++V Sbjct: 105 WVSSLDVGDGSKHIISGSYDGIVRTWDL---SGNVQ--KQYSGHSGPIRAVKYISNTRLV 159 Query: 159 TSSGDTTCALW-----------------------DIETGQQTTTFTGHTGDVMSLSLAPD 195 ++ D T LW +IE G+ GH V+S+ ++ + Sbjct: 160 SAGNDRTLRLWKTKNDDLKLTSQQQAQEDDDDEVNIEDGKTLAILEGHKAPVVSIDVSDN 219 Query: 196 TRLFVSGACDASAKLW 211 +R+ S + D S W Sbjct: 220 SRIL-SASYDNSIGFW 234 Score = 39.3 bits (90), Expect = 0.002, Method: Compositional matrix adjust. Identities = 51/237 (21%), Positives = 97/237 (40%), Gaps = 31/237 (13%) Query: 46 RTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAY 105 +T L GH A + ++ +SR+L SAS D + W + PL Sbjct: 199 KTLAILEGHKAPVVSIDVSDNSRIL-SASYDNSIGFWSTIYKEMTVVDPLED-------I 250 Query: 106 APSGNYVACGGLDNICSIYNLKTREGNVRVSRELA---GHTGYLSCCRFLDDNQIV--TS 160 N ++ L ++G +R L+ HT + F + V + Sbjct: 251 NNPNNKISTAARKR----RKLTMKDGTIRRRAPLSLLESHTAPVEQVIFDSTDNTVGYSV 306 Query: 161 SGDTTCALWDIETGQ----QTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREG 216 S D T WD+ T + +TT+++ ++S++ L G+ L D R G Sbjct: 307 SQDHTIKTWDLVTARCIDTRTTSYS-----LLSIAQLSTLNLLACGSSARHITLHDPRVG 361 Query: 217 ----MCRQTFTGHESDINAICFFP-NGNAFATGSDDATCRLFDLRADQELMTYSHDN 268 + +Q GH++ ++++ P N +GS D T +++D+R+ + T + ++ Sbjct: 362 ASSKVTQQQLIGHKNFVSSLDTCPENEYILCSGSHDGTVKVWDVRSTSPMYTITRED 418 Score = 38.5 bits (88), Expect = 0.004, Method: Compositional matrix adjust. Identities = 33/154 (21%), Positives = 64/154 (41%), Gaps = 24/154 (15%) Query: 187 VMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSD 246 V SL + ++ +SG+ D + WD+ G ++ ++GH I A+ + N + G + Sbjct: 106 VSSLDVGDGSKHIISGSYDGIVRTWDL-SGNVQKQYSGHSGPIRAVKYISNTRLVSAG-N 163 Query: 247 DATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAG 306 D T RL+ + D +T V+ + G+ L Sbjct: 164 DRTLRLWKTKNDDLKLTSQQQAQEDDDDEVNI-EDGKTL--------------------A 202 Query: 307 VLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 +L GH V + V+D+ + + S+D+ + W+ Sbjct: 203 ILEGHKAPVVSIDVSDNSR-ILSASYDNSIGFWS 235 Score = 30.4 bits (67), Expect = 1.3, Method: Compositional matrix adjust. Identities = 19/58 (32%), Positives = 26/58 (44%), Gaps = 4/58 (6%) Query: 173 TGQQTTTFTGHTGDVMSLSLAPDTRLFV-SGACDASAKLWDVREGMCRQTFTGHESDI 229 T QQ GH V SL P+ + SG+ D + K+WDVR T T + + Sbjct: 367 TQQQ---LIGHKNFVSSLDTCPENEYILCSGSHDGTVKVWDVRSTSPMYTITREDKSV 421 >5BJS-A nrPDB Length = 605 Score = 44.7 bits (104), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 32/113 (28%), Positives = 51/113 (45%), Gaps = 15/113 (13%) Query: 195 DTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFP-NGNAFATGSDDATCRLF 253 D L + + K+++V EG +T GH IN + P N A+ SDD T R++ Sbjct: 147 DQPLLCIAGNEGNVKVYNVTEGKLYRTLVGHGGGINDLATSPANPYIIASASDDTTIRIW 206 Query: 254 DLRADQELMT---------YSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVW 297 L + E +S+D + SV+F +GR +L+ D N+W Sbjct: 207 SLAPEHEKQPCVCILGGEGHSYD-----LLSVAFHDNGRYVLSAGHDQVINLW 254 Score = 37.4 bits (85), Expect = 0.009, Method: Compositional matrix adjust. Identities = 30/124 (24%), Positives = 51/124 (41%), Gaps = 22/124 (17%) Query: 130 EGNVRVS--------RELAGHTGYLSCCRFLDDNQ--IVTSSGDTTCALWDIETGQQTTT 179 EGNV+V R L GH G ++ N I ++S DTT +W + + Sbjct: 157 EGNVKVYNVTEGKLYRTLVGHGGGINDLATSPANPYIIASASDDTTIRIWSLAPEHEKQP 216 Query: 180 FT------GHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAIC 233 GH+ D++S++ + R +S D LW + E F +I + Sbjct: 217 CVCILGGEGHSYDLLSVAFHDNGRYVLSAGHDQVINLWALPE------FPNEHMEIPIVI 270 Query: 234 FFPN 237 ++P+ Sbjct: 271 YYPH 274 Score = 32.7 bits (73), Expect = 0.23, Method: Compositional matrix adjust. Identities = 27/136 (19%), Positives = 50/136 (36%), Gaps = 11/136 (8%) Query: 153 DDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACD-ASAKLW 211 D + + + ++++ G+ T GH G + L+ +P ++ A D + ++W Sbjct: 147 DQPLLCIAGNEGNVKVYNVTEGKLYRTLVGHGGGINDLATSPANPYIIASASDDTTIRIW 206 Query: 212 DVREGMCRQTFT------GHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYS 265 + +Q GH D+ ++ F NG + D L+ L Sbjct: 207 SLAPEHEKQPCVCILGGEGHSYDLLSVAFHDNGRYVLSAGHDQVINLWALPE----FPNE 262 Query: 266 HDNIICGITSVSFSKS 281 H I I FS S Sbjct: 263 HMEIPIVIYYPHFSSS 278 >4A11-B nrPDB Length = 408 Score = 44.7 bits (104), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 47/192 (24%), Positives = 76/192 (39%), Gaps = 33/192 (17%) Query: 153 DDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTR---LFVSGACDASAK 209 D +SS D T +WD T Q F V S ++P + L G + Sbjct: 111 DTGMFTSSSFDKTLKVWDTNTLQTADVFNFEE-TVYSHHMSPVSTKHCLVAVGTRGPKVQ 169 Query: 210 LWDVREGMCRQTFTGHESDINAICFFPNGN-AFATGSDDATCRLFDLRADQELMTYSHDN 268 L D++ G C GH +I A+ + P + AT S D+ +L+D+R Sbjct: 170 LCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVR------------ 217 Query: 269 IICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVA 328 SG L+ D N A+++ H+ +V+ L T DG+ + Sbjct: 218 ----------RASGCLITL--DQHNGKKSQAVESANTA----HNGKVNGLCFTSDGLHLL 261 Query: 329 TGSWDSFLKIWN 340 T D+ +++WN Sbjct: 262 TVGTDNRMRLWN 273 Score = 42.7 bits (99), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 44/193 (22%), Positives = 77/193 (39%), Gaps = 22/193 (11%) Query: 168 LWDIETGQQTTTFTGHTGDVMSLSLAPDT-RLFVSGACDASAKLWDVREGM-CRQTF--- 222 L D+++G + GH +++++S +P + + + D+ KLWDVR C T Sbjct: 170 LCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQH 229 Query: 223 ------------TGHESDINAICFFPNGNAFATGSDDATCRLFDL-RADQELMTYSH--D 267 T H +N +CF +G T D RL++ + L+ Y + Sbjct: 230 NGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCN 289 Query: 268 NIICGIT-SVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMA 326 N G+ +VS S + Y V+ ++ +L GH V C + Sbjct: 290 NSKKGLKFTVSCGCSSEFVFVPYGS-TIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQE 348 Query: 327 VATGSWDSFLKIW 339 + +GS D + W Sbjct: 349 LYSGSRDCNILAW 361 >5WLC-LJ nrPDB Length = 513 Score = 44.3 bits (103), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 40/156 (25%), Positives = 73/156 (46%), Gaps = 16/156 (10%) Query: 195 DTRLFVSGACDASAKLWDVREGMCRQ-TFTGHESDINAICFFPNG-NAFATGSDDATCRL 252 D ++ + + D +LWD+ Q TG + + F P + ATGS D RL Sbjct: 136 DNKILATASDDRVTRLWDISNAYEPQLELTGATDYVRTLSFIPAAPHLVATGSYDGLIRL 195 Query: 253 FDLRADQELMTYS--HDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAG 310 +D R+ YS HD + + +VS ++ ++ G ++F VWD L +++ G Sbjct: 196 YDTRSSGSTPIYSLNHDQPVENVIAVSPTQ---IVSCGGNNF--KVWD-LTSNKKLYERG 249 Query: 311 HDNR-VSCLGVTDD-----GMAVATGSWDSFLKIWN 340 + N+ V+CL ++ A+ S D +K+++ Sbjct: 250 NFNKAVTCLDYVENFDSPMQSALIASSLDGHVKVFD 285 Score = 33.5 bits (75), Expect = 0.12, Method: Compositional matrix adjust. Identities = 51/252 (20%), Positives = 95/252 (37%), Gaps = 57/252 (22%) Query: 58 IYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGL 117 +Y+ + +D +LL + G + ++DS Sbjct: 84 VYSASFRSDGKLLCAGDATGLVSVYDS--------------------------------- 110 Query: 118 DNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQT 177 YN +T + +S + H +++ D+ + T+S D LWDI + Sbjct: 111 ------YNPRT----ILLSINASTHPTHVTKFHTQDNKILATASDDRVTRLWDISNAYEP 160 Query: 178 T-TFTGHTGDVMSLSLAP-DTRLFVSGACDASAKLWDVREGMCRQTFT-GHESDI-NAIC 233 TG T V +LS P L +G+ D +L+D R ++ H+ + N I Sbjct: 161 QLELTGATDYVRTLSFIPAAPHLVATGSYDGLIRLYDTRSSGSTPIYSLNHDQPVENVIA 220 Query: 234 FFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSF-----SKSGRLLLAG 288 P G++ +++DL ++++L Y N +T + + S L+A Sbjct: 221 VSPTQIVSCGGNN---FKVWDLTSNKKL--YERGNFNKAVTCLDYVENFDSPMQSALIAS 275 Query: 289 YDDFNCNVWDAL 300 D + V+D L Sbjct: 276 SLDGHVKVFDPL 287 >1NR0-A nrPDB Length = 611 Score = 44.3 bits (103), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 69/320 (21%), Positives = 118/320 (36%), Gaps = 66/320 (20%) Query: 77 GKLIIWDSYTTNKV--HAIPLRSSWVMTCAY-APSGNYVACG-GLDNICSIYNLKTREGN 132 G + IWD+ T + IP+ S V ++ + S A G G + ++ T N Sbjct: 81 GNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSN 140 Query: 133 VRVSRELAGHTGYLSCCRFLDDN--QIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSL 190 L G ++ F +I++ S D T A+++ + +TF HT V S+ Sbjct: 141 ----GNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSV 196 Query: 191 SLAPDTRLFVSGACDASAKLWDVREGMCRQTF-------TGHESDINAICFFPNGNAFAT 243 PD LF S D + L++ +G F H + + + P+G A+ Sbjct: 197 RYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIAS 256 Query: 244 GSDDATCRLFDLRA--------------DQEL---------------------------- 261 S D T +++++ DQ+L Sbjct: 257 ASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSI 316 Query: 262 --MTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAG-HDNRVSCL 318 + Y H+ IT++S S G+ L + + + N WD V H ++ + Sbjct: 317 DQVRYGHNK---AITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGI 373 Query: 319 GVTDDGMAVATGSWDSFLKI 338 T G + T SWD LK+ Sbjct: 374 KTTSKG-DLFTVSWDDHLKV 392 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 42/221 (19%), Positives = 79/221 (35%), Gaps = 28/221 (12%) Query: 44 QMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIP-------LR 96 + + T H ++++ + D L S DG +++++ K Sbjct: 179 PFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAH 238 Query: 97 SSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQ 156 S V ++P G +A D I+N+ T ++V + + T ++D Q Sbjct: 239 SGSVFGLTWSPDGTKIASASADKTIKIWNVAT----LKVEKTIPVGTR-------IEDQQ 287 Query: 157 I---------VTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDAS 207 + V+ S + + E G GH + +LS + D + S + Sbjct: 288 LGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGH 347 Query: 208 AKLWDVREGMCRQTFTG-HESDINAICFFPNGNAFATGSDD 247 WD+ G+ + F H + I I G+ F DD Sbjct: 348 INSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDD 388 Score = 38.1 bits (87), Expect = 0.005, Method: Compositional matrix adjust. Identities = 32/133 (24%), Positives = 54/133 (40%), Gaps = 10/133 (7%) Query: 216 GMCRQTFTGHESDINAICFFPNGN-AFATGSDDATCRLFDLRADQELMTYSHDNIICGIT 274 G TG +N++ F P+ +GSDD T +F+ + T+ + Sbjct: 137 GTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKF--VH 194 Query: 275 SVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVL-------AGHDNRVSCLGVTDDGMAV 327 SV ++ G L + D +++ + + GV H V L + DG + Sbjct: 195 SVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKI 254 Query: 328 ATGSWDSFLKIWN 340 A+ S D +KIWN Sbjct: 255 ASASADKTIKIWN 267 Score = 35.4 bits (80), Expect = 0.034, Method: Compositional matrix adjust. Identities = 28/104 (26%), Positives = 47/104 (45%), Gaps = 8/104 (7%) Query: 242 ATGSDDATCRLFDLRADQ--ELMTYSHDNIICGITSVSFSKSGRLLLA---GYDDFNCNV 296 A G D+ ++ L E+ T H ITSV+FS +G L+A +V Sbjct: 464 AVGGQDSKVHVYKLSGASVSEVKTIVHP---AEITSVAFSNNGAFLVATDQSRKVIPYSV 520 Query: 297 WDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 + + H +V+C+ + D + +ATGS D+ + +WN Sbjct: 521 ANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWN 564 Score = 31.2 bits (69), Expect = 0.76, Method: Compositional matrix adjust. Identities = 28/136 (20%), Positives = 60/136 (44%), Gaps = 10/136 (7%) Query: 85 YTTNKVHAIPLRSSWVMTC-AYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHT 143 Y+ K+ +P+ S+ +C A + +VA GG D+ +Y L G + H Sbjct: 437 YSHGKLTEVPI--SYNSSCVALSNDKQFVAVGGQDSKVHVYKL---SGASVSEVKTIVHP 491 Query: 144 GYLSCCRFLDDNQIVTSSGDTTCAL-WDIETG---QQTTTFTGHTGDVMSLSLAPDTRLF 199 ++ F ++ + ++ + + + + T ++T HT V +S +PD Sbjct: 492 AEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRL 551 Query: 200 VSGACDASAKLWDVRE 215 +G+ D S +W++ + Sbjct: 552 ATGSLDNSVIVWNMNK 567 >4YCZ-A nrPDB Length = 876 Score = 44.3 bits (103), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 62/281 (22%), Positives = 95/281 (33%), Gaps = 68/281 (24%) Query: 45 MRTRRTLRGHLAKIYAMHWGTDS--RLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMT 102 R TL+GH ++ + W +L SA DGK++IW L +W Sbjct: 52 QRLTETLKGHDGAVWCVSWAHPKYGNILASAGYDGKVLIWRE----------LNGAW--- 98 Query: 103 CAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSG 162 I++ + +V V G L C D N V Sbjct: 99 ------------------QRIFDFALHKASVNVVSWSPHEAGCLLACASSDGNVSVLEFR 140 Query: 163 DTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDT-----------------RLFVSGACD 205 D + + + F H V S+S AP T R FV+G D Sbjct: 141 DNSW---------EHSIFHAHGLGVNSVSWAPATSPGSIVSSKPGPKSTGNRRFVTGGSD 191 Query: 206 ASAKLWDVREG-----MCRQTFTGHESDINAICFFP---NGNAFATGSDDATCRLFDLRA 257 + K+W + R+ TGH + + + P + A+ S+D T R++ Sbjct: 192 NALKIWAYDPATNTYKLEREPLTGHTDWVRDVAWSPTVLQKSYIASASEDRTVRIWTSDP 251 Query: 258 DQELMTYSHD-NIICGITSVSFSKSGRLLLAGYDDFNCNVW 297 L N + VS+S SG +L A D +W Sbjct: 252 ANPLQWNCKVLNFDAAVWRVSWSLSGNVLAASGGDNKVTLW 292 >5CXC-A nrPDB Length = 510 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 56/278 (20%), Positives = 104/278 (37%), Gaps = 45/278 (16%) Query: 107 PSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTC 166 P V D + I+N S GHT + +FL +++ ++ D T Sbjct: 156 PGQERVLSASYDGLLRIWNASGSVIATSPSGSHGGHTASIKAAKFLTSDRLASAGMDRTV 215 Query: 167 ALW-----DIETGQQTTTFT--GHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCR 219 +W D TG+ T GHTG V L + ++ ++ + D + W + Sbjct: 216 RVWKYTESDHFTGELKPTLELYGHTGSVDWLDVDGHSKHILTASADGAIGFWSASKASAP 275 Query: 220 QT------------------------------FTGHESDINAICFFPNGNAFA-TGSDDA 248 + ++ H + A F P A + S D Sbjct: 276 EPDASLLPGAHVSKRRKATSSVSTAQRGPLGLWSIHTAPATAAIFDPRDRTVAYSASQDH 335 Query: 249 TCRLFDLRADQELMTYSHDNIICGITSVSFS-KSGRLLLAGYDDFNCNVWDALKADRAG- 306 T R DL Q + T + + + +++++ + + LL AG + + D +A A Sbjct: 336 TVRTLDLTTGQVVSTLTLTHPLLSLSALTRAGTTSPLLAAGTSARHITMVDP-RASSATT 394 Query: 307 ---VLAGHDNRVSCLGVT-DDGMAVATGSWDSFLKIWN 340 L GH N+V L + ++ ++ +GS D ++W+ Sbjct: 395 SVMTLRGHANKVVSLSPSPENEYSLVSGSHDGTCRVWD 432 Score = 37.0 bits (84), Expect = 0.013, Method: Compositional matrix adjust. Identities = 35/126 (27%), Positives = 56/126 (44%), Gaps = 11/126 (8%) Query: 142 HTGYLSCCRFLDDNQIV--TSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSL----APD 195 HT + F ++ V ++S D T D+ TGQ +T T T ++SLS Sbjct: 311 HTAPATAAIFDPRDRTVAYSASQDHTVRTLDLTTGQVVSTLT-LTHPLLSLSALTRAGTT 369 Query: 196 TRLFVSGACDASAKLWDVREGMCR---QTFTGHESDINAICFFP-NGNAFATGSDDATCR 251 + L +G + D R T GH + + ++ P N + +GS D TCR Sbjct: 370 SPLLAAGTSARHITMVDPRASSATTSVMTLRGHANKVVSLSPSPENEYSLVSGSHDGTCR 429 Query: 252 LFDLRA 257 ++DLR+ Sbjct: 430 VWDLRS 435 >5OQL-X nrPDB Length = 630 Score = 42.0 bits (97), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 55/269 (20%), Positives = 99/269 (36%), Gaps = 20/269 (7%) Query: 4 LDQLRQEAEQLKNQIRDARKACADATLSQITNNI-DPVGRIQMRTRRTLRGHLAKIYAMH 62 L++ R+E EQL DA + D ++ ++ + G++ R L A Sbjct: 108 LEKTRKEVEQLDEYAFDAEEIDRDLLAERLKEDVAEAKGKVYRRLASELAFDKATYTQFR 167 Query: 63 W--GTDSRLLV------SASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVAC 114 W GT + + V + ++DG L W K+ +P ++ W T P Sbjct: 168 WNSGTVTSVAVCPPYAYTTTKDGYLTKW------KLQDLP-KNQWPQTTKKKPKKPPAPP 220 Query: 115 GGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSG-DTTCALWDIET 173 R+ N + GH + D + V + G D +++ Sbjct: 221 KKRPERICFAKADARKAN---DKTYQGHLKAPLVVKASQDGKFVVTGGADKRLVVYNAAD 277 Query: 174 GQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAIC 233 + FT H V L+ T S + D + K+W + E +T GH+ +I I Sbjct: 278 LKPIKAFTQHRDAVTGLAFRRGTNQLYSCSKDRTVKVWSLDELAYVETLFGHQDEILDID 337 Query: 234 FFPNGNAFATGSDDATCRLFDLRADQELM 262 + G+ D T R + + + +L+ Sbjct: 338 ALGQERCVSVGARDRTARYWKVPEESQLV 366 Score = 27.7 bits (60), Expect = 7.3, Method: Compositional matrix adjust. Identities = 12/33 (36%), Positives = 17/33 (51%) Query: 140 AGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIE 172 A H G + +DD+ VT S + ALW I+ Sbjct: 392 AAHEGSMDRVAMIDDDMFVTGSDNGDLALWSIQ 424 >5WLC-LL nrPDB Length = 643 Score = 42.0 bits (97), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 25/90 (27%), Positives = 43/90 (47%), Gaps = 3/90 (3%) Query: 165 TCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGA-CDASAKLWDVREGMCRQTFT 223 + +L DIE + TF GH V +L + + F+SGA D ++D+ GM + Sbjct: 169 SISLIDIEEKKVVMTFPGHVSPVSTLQVITN-EFFISGAEGDRFLNVYDIHSGMTKCVLV 227 Query: 224 GHESDINAICFFPNGNAFATGSDDATCRLF 253 ESDI + ++ A ++D + +F Sbjct: 228 A-ESDIKELSHSGQADSIAVTTEDGSLEIF 256 >5A9Q-0 nrPDB Length = 380 Score = 42.0 bits (97), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 49/215 (22%), Positives = 88/215 (40%), Gaps = 26/215 (12%) Query: 66 DSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVM----TCAYAPSGNYVACGGLDNIC 121 D +V+AS G + ++ + N+ + + W T +PS + C G+ +C Sbjct: 84 DQERIVAASSTGCVTVFLHHPNNQT--LSVNQQWTTAHYHTGPGSPSYSSAPCTGV--VC 139 Query: 122 SIYNLKTREGNVRVSRELAGH-----------TGYLSCCRFLDDNQIVTSSGDTTCALWD 170 + + T + R++ A H + L FL +I+T + +WD Sbjct: 140 NNPEIVTVGEDGRINLFRADHKEAVRTIDNADSSTLHAVTFLRTPEILTVNSIGQLKIWD 199 Query: 171 I-ETGQQTTTFTGHTGDVMSLSLA---PDTRLFV-SGACDASAKLWDVREG-MCRQTFTG 224 + G + + TGD + L P+ + V +G D +WDVR+G M Sbjct: 200 FRQQGNEPSQILSLTGDRVPLHCVDRHPNQQHVVATGGQDGMLSIWDVRQGTMPVSLLKA 259 Query: 225 HESDINAICFFP-NGNAFATGSDDATCRLFDLRAD 258 HE+++ + F P N T S+D + +D D Sbjct: 260 HEAEMWEVHFHPSNPEHLFTCSEDGSLWHWDASTD 294 >2P9P-C nrPDB Length = 372 Score = 41.6 bits (96), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 32/128 (25%), Positives = 52/128 (40%), Gaps = 4/128 (3%) Query: 176 QTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAIC-- 233 Q H G V + APD+ V+ D +A +W ++ + T + A C Sbjct: 44 QVHELKEHNGQVTGVDWAPDSNRIVTCGTDRNAYVWTLKGRTWKPTLVILRINRAARCVR 103 Query: 234 FFPNGNAFATGSDDATCRL--FDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDD 291 + PN FA GS + F+ D + + I + S+ + + LL AG D Sbjct: 104 WAPNEKKFAVGSGSRVISICYFEQENDWWVCKHIKKPIRSTVLSLDWHPNSVLLAAGSCD 163 Query: 292 FNCNVWDA 299 F C ++ A Sbjct: 164 FKCRIFSA 171 Score = 36.6 bits (83), Expect = 0.017, Method: Compositional matrix adjust. Identities = 50/237 (21%), Positives = 94/237 (39%), Gaps = 47/237 (19%) Query: 89 KVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGN-----VRVSRELAGHT 143 +VH + + V +AP N + G D ++ LK R +R++R Sbjct: 44 QVHELKEHNGQVTGVDWAPDSNRIVTCGTDRNAYVWTLKGRTWKPTLVILRINRA----- 98 Query: 144 GYLSCCRFL-DDNQIVTSSGDTTCAL---------WDIETGQQTTTFTGHTGDVMSLSLA 193 C R+ ++ + SG ++ W + ++ T V+SL Sbjct: 99 --ARCVRWAPNEKKFAVGSGSRVISICYFEQENDWWVCKHIKKPIRST-----VLSLDWH 151 Query: 194 PDTRLFVSGACDASAKLWD--VREGMCRQTFTGHESD----------------INAICFF 235 P++ L +G+CD +++ ++E R T S ++ +CF Sbjct: 152 PNSVLLAAGSCDFKCRIFSAYIKEVEERPAPTPWGSKMPFGELMFESSSSCGWVHGVCFS 211 Query: 236 PNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDF 292 NG+ A S D+T L D AD+++ + + + +V+F L+ AG+D F Sbjct: 212 ANGSRVAWVSHDSTVCLAD--ADKKMAVATLASETLPLLAVTFITESSLVAAGHDCF 266 >4G56-B nrPDB Length = 357 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 36/145 (24%), Positives = 63/145 (43%), Gaps = 7/145 (4%) Query: 122 SIYNLKTREGNVRVSRELAG--HTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQ--T 177 SI+ K EG S AG ++ ++ + I+ +S LW+I + Sbjct: 71 SIWVFKDPEGAPNESLCTAGVQTEAGVTDVAWVSEKGILVASDSGAVELWEILEKESLLV 130 Query: 178 TTFTGHTGD--VMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFF 235 F + D V +LS+ D VSG D S K+WD+ + +++ H S++N + Sbjct: 131 NKFAKYEHDDIVKTLSVFSDGTQAVSGGKDFSVKVWDLSQKAVLKSYNAHSSEVNCVAAC 190 Query: 236 PNGNA-FATGSDDATCRLFDLRADQ 259 P + F + +D L+D R + Sbjct: 191 PGKDTIFLSCGEDGRILLWDTRKPK 215 Score = 27.7 bits (60), Expect = 6.8, Method: Compositional matrix adjust. Identities = 20/73 (27%), Positives = 34/73 (46%), Gaps = 5/73 (6%) Query: 272 GITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGV----LAGHDNRVSCLGVTDDGMAV 327 G+T V++ +L+A D +W+ L+ + V HD+ V L V DG Sbjct: 96 GVTDVAWVSEKGILVAS-DSGAVELWEILEKESLLVNKFAKYEHDDIVKTLSVFSDGTQA 154 Query: 328 ATGSWDSFLKIWN 340 +G D +K+W+ Sbjct: 155 VSGGKDFSVKVWD 167 >2AQ5-A nrPDB Length = 402 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 36/159 (22%), Positives = 60/159 (37%), Gaps = 13/159 (8%) Query: 153 DDNQIVTSSGDTTCALWDIETG-------QQTTTFTGHTGDVMSLSLAPDTR-LFVSGAC 204 +DN I + S D T +W+I G + T GHT V ++ P + + +S C Sbjct: 93 NDNVIASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKRVGIVAWHPTAQNVLLSAGC 152 Query: 205 DASAKLWDVREGMCRQTFTG--HESDINAICFFPNGNAFATGSDDATCRLFDLRADQELM 262 D +WDV G T H I ++ + +G T D R+ + R + Sbjct: 153 DNVILVWDVGTGAAVLTLGPDVHPDTIYSVDWSRDGALICTSCRDKRVRVIEPRKGTVVA 212 Query: 263 TYSHDNIICGITSVSFSKSGRLLLAGY---DDFNCNVWD 298 + F G++L G+ + +WD Sbjct: 213 EKDRPHEGTRPVHAVFVSEGKILTTGFSRMSERQVALWD 251 >5WLC-LW nrPDB Length = 554 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 37/153 (24%), Positives = 69/153 (45%), Gaps = 6/153 (3%) Query: 151 FLDDNQIVTSSGDTT-CALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAK 209 FL + ++ ++G+T D+ TGQ + G M+++ P + G + + Sbjct: 198 FLPYHYLLVTAGETGWLKYHDVSTGQLVSELRTKAGPTMAMAQNPWNAVMHLGHSNGTVS 257 Query: 210 LWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNI 269 LW +N+I +G AT D + +++D+R ++L +S +++ Sbjct: 258 LWSPSMPEPLVKLLSARGPVNSIAIDRSGYYMATTGADRSMKIWDIRNFKQL--HSVESL 315 Query: 270 ICGITSVSFSKSGRLLLAGYDDFNCNVW-DALK 301 T+VS S +G LLA + +W DALK Sbjct: 316 PTPGTNVSISDTG--LLALSRGPHVTLWKDALK 346 >4E5Z-B nrPDB Length = 436 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 33/155 (21%), Positives = 63/155 (40%), Gaps = 13/155 (8%) Query: 174 GQQTTTFTGHTGDVMSLSLAPDTRLFVSGA-CDASAKLWDVREGMCRQTFT---GHESDI 229 G++ H V ++L P F++ A D + K+WD+R+ + +F H + Sbjct: 240 GKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPV 299 Query: 230 NAICFFPNGNAFATGSDDATCRLFDLRADQ-----ELMTYSHDNI--ICGITSVSFSKSG 282 NA CF P+G T + R++ A Q L+ + H + + I + + Sbjct: 300 NAACFSPDGARLLTTDQKSEIRVYS--ASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYN 357 Query: 283 RLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSC 317 +++ Y D N + V G+ ++ C Sbjct: 358 LIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMC 392 >1PI6-A nrPDB Length = 615 Score = 39.3 bits (90), Expect = 0.002, Method: Compositional matrix adjust. Identities = 50/234 (21%), Positives = 94/234 (40%), Gaps = 22/234 (9%) Query: 51 LRGHLAKIYAMHWGTDSRLL--VSASQDGKLIIWDSYT-----TNKVHAIPLRSSWVMTC 103 + GH +I A H SR + ++ DG ++ + +++ H + S+V Sbjct: 156 VSGHSQRINACHL-KQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHH--KQGSFVRDV 212 Query: 104 AYAP-SGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSG 162 ++P SG +V G D S ++ K+ E + + G + +LD + T Sbjct: 213 EFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGA 272 Query: 163 DTTCALWDIETG---QQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCR 219 D T +WD+ T Q+ T G+ +A +S + D + +++ Sbjct: 273 DATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVL 332 Query: 220 QTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGI 273 +T +GH I A+ N +GS D R+ + + M H N+I + Sbjct: 333 KTISGHNKGITALTV----NPLISGSYDG--RIMEWSSSS--MHQDHSNLIVSL 378 Score = 35.4 bits (80), Expect = 0.032, Method: Compositional matrix adjust. Identities = 39/159 (24%), Positives = 69/159 (43%), Gaps = 20/159 (12%) Query: 185 GDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDI--NAICFFPNGNA-F 241 G + +LS D++ F + DA+ ++WDV C Q +T + + + GN Sbjct: 254 GGIFALSWL-DSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRI 312 Query: 242 ATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVW--DA 299 + S D T ++L D+ L T S N GIT+++ + L++G D W + Sbjct: 313 ISLSLDGTLNFYELGHDEVLKTISGHN--KGITALTVNP----LISGSYDGRIMEWSSSS 366 Query: 300 LKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKI 338 + D + ++ DN ++ SWD LK+ Sbjct: 367 MHQDHSNLIVSLDN--------SKAQEYSSISWDDTLKV 397 Score = 29.6 bits (65), Expect = 1.8, Method: Compositional matrix adjust. Identities = 33/132 (25%), Positives = 59/132 (44%), Gaps = 17/132 (12%) Query: 94 PLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRF-- 151 PLR+ + +PS Y+A G + +Y+L++RE V+ SR A T ++ + Sbjct: 486 PLRAK-PSYISISPSETYIAAGDVMGKILLYDLQSRE--VKTSR-WAFRTSKINAISWKP 541 Query: 152 ---------LDDNQIVTSSGDTTCALWDIETGQQ-TTTFTGHTGDVMSLSLAPDTRLFVS 201 ++++ + T S DT ++ ++ + H V +L + L S Sbjct: 542 AEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLWETPSTLVSS 601 Query: 202 GACDASAKLWDV 213 GA DA K W+V Sbjct: 602 GA-DACIKRWNV 612 >4J0X-A nrPDB Length = 451 Score = 39.3 bits (90), Expect = 0.002, Method: Compositional matrix adjust. Identities = 70/313 (22%), Positives = 113/313 (36%), Gaps = 65/313 (20%) Query: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPL--RSSWVMTCAYAP 107 T GH +I + D + +V+ +D KLI+W + + + V IP R V++ A+ Sbjct: 109 TTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRRGEVLSLAFRK 168 Query: 108 SGNYVACGGLDNICSIYNLKTREGNVRVSRE-LAGHTGYLSCCRFLDDNQIVT-SSGDTT 165 + + + C+ + ++T N E L GH + L + VT + D T Sbjct: 169 NSDQLYAS-----CADFKIRTYSINQFSQLEILYGHHDIVEDISALAMERCVTVGARDRT 223 Query: 166 CALWDIETGQQTTTFTGHTGDVMSLSLAPD-TRLFVSGACDASAKLWDVREGMCRQTFTG 224 LW I PD TRL G D KL +R M G Sbjct: 224 AMLWKI----------------------PDETRLTFRGG-DEPQKL--LRRWMKENAKEG 258 Query: 225 HESDIN------AICFFPNGNA----------FATGSDDATCRLFDLRADQELMTYSHDN 268 + ++ A FF G+ F TGSD+ L+ L + + T + Sbjct: 259 EDGEVKYPDESEAPLFFCEGSIDVVSMVDDFHFITGSDNGNICLWSLAKKKPIFT---ER 315 Query: 269 IICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADR-AGVLAGHDNRVSCLGVTDDGMAV 327 I GI L ++D + + L+ + G ++ L Sbjct: 316 IAHGI----------LPEPSFNDISGETDEELRKRQLQGKKLLQPFWITSLYAIPYSNVF 365 Query: 328 ATGSWDSFLKIWN 340 +GSW LK+W Sbjct: 366 ISGSWSGSLKVWK 378 Score = 31.6 bits (70), Expect = 0.57, Method: Compositional matrix adjust. Identities = 30/155 (19%), Positives = 53/155 (34%), Gaps = 4/155 (2%) Query: 186 DVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGS 245 D+ S P + G AK + T GH +I + P+G TG Sbjct: 78 DITDFSKRPKKLKYAKGG----AKYIPTSKHEYENTTEGHYDEILTVAASPDGKYVVTGG 133 Query: 246 DDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRA 305 D ++ + + + + S++F K+ L A DF + + + Sbjct: 134 RDRKLIVWSTESLSPVKVIPTKDRRGEVLSLAFRKNSDQLYASCADFKIRTYSINQFSQL 193 Query: 306 GVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 +L GH + V + V G+ D +W Sbjct: 194 EILYGHHDIVEDISALAMERCVTVGARDRTAMLWK 228 Score = 30.0 bits (66), Expect = 1.5, Method: Compositional matrix adjust. Identities = 33/129 (25%), Positives = 52/129 (40%), Gaps = 15/129 (11%) Query: 218 CRQTFTG-HESDINAI-CFFPNGNAF----ATGSDDATCRLFDLRADQELMTYSHDNIIC 271 +Q+FT E+++ I CF P N + ++ D RLF ++L +D Sbjct: 23 AKQSFTRVGENNLTCISCFQPVLNKYTFEESSNGDKNKGRLFAYTVSKDLQLTKYD---- 78 Query: 272 GITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGS 331 IT FSK + L Y K + GH + + + + DG V TG Sbjct: 79 -ITD--FSKRPKKL--KYAKGGAKYIPTSKHEYENTTEGHYDEILTVAASPDGKYVVTGG 133 Query: 332 WDSFLKIWN 340 D L +W+ Sbjct: 134 RDRKLIVWS 142 >5WLC-SG nrPDB Length = 573 Score = 39.3 bits (90), Expect = 0.003, Method: Compositional matrix adjust. Identities = 70/313 (22%), Positives = 113/313 (36%), Gaps = 65/313 (20%) Query: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPL--RSSWVMTCAYAP 107 T GH +I + D + +V+ +D KLI+W + + + V IP R V++ A+ Sbjct: 231 TTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRRGEVLSLAFRK 290 Query: 108 SGNYVACGGLDNICSIYNLKTREGNVRVSRE-LAGHTGYLSCCRFLDDNQIVT-SSGDTT 165 + + + C+ + ++T N E L GH + L + VT + D T Sbjct: 291 NSDQLYAS-----CADFKIRTYSINQFSQLEILYGHHDIVEDISALAMERCVTVGARDRT 345 Query: 166 CALWDIETGQQTTTFTGHTGDVMSLSLAPD-TRLFVSGACDASAKLWDVREGMCRQTFTG 224 LW I PD TRL G D KL +R M G Sbjct: 346 AMLWKI----------------------PDETRLTFRGG-DEPQKL--LRRWMKENAKEG 380 Query: 225 HESDIN------AICFFPNGNA----------FATGSDDATCRLFDLRADQELMTYSHDN 268 + ++ A FF G+ F TGSD+ L+ L + + T + Sbjct: 381 EDGEVKYPDESEAPLFFCEGSIDVVSMVDDFHFITGSDNGNICLWSLAKKKPIFT---ER 437 Query: 269 IICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADR-AGVLAGHDNRVSCLGVTDDGMAV 327 I GI L ++D + + L+ + G ++ L Sbjct: 438 IAHGI----------LPEPSFNDISGETDEELRKRQLQGKKLLQPFWITSLYAIPYSNVF 487 Query: 328 ATGSWDSFLKIWN 340 +GSW LK+W Sbjct: 488 ISGSWSGSLKVWK 500 Score = 31.2 bits (69), Expect = 0.68, Method: Compositional matrix adjust. Identities = 30/155 (19%), Positives = 53/155 (34%), Gaps = 4/155 (2%) Query: 186 DVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGS 245 D+ S P + G AK + T GH +I + P+G TG Sbjct: 200 DITDFSKRPKKLKYAKGG----AKYIPTSKHEYENTTEGHYDEILTVAASPDGKYVVTGG 255 Query: 246 DDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRA 305 D ++ + + + + S++F K+ L A DF + + + Sbjct: 256 RDRKLIVWSTESLSPVKVIPTKDRRGEVLSLAFRKNSDQLYASCADFKIRTYSINQFSQL 315 Query: 306 GVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 +L GH + V + V G+ D +W Sbjct: 316 EILYGHHDIVEDISALAMERCVTVGARDRTAMLWK 350 Score = 30.0 bits (66), Expect = 1.6, Method: Compositional matrix adjust. Identities = 33/129 (25%), Positives = 52/129 (40%), Gaps = 15/129 (11%) Query: 218 CRQTFTG-HESDINAI-CFFPNGNAF----ATGSDDATCRLFDLRADQELMTYSHDNIIC 271 +Q+FT E+++ I CF P N + ++ D RLF ++L +D Sbjct: 145 AKQSFTRVGENNLTCISCFQPVLNKYTFEESSNGDKNKGRLFAYTVSKDLQLTKYD---- 200 Query: 272 GITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGS 331 IT FSK + L Y K + GH + + + + DG V TG Sbjct: 201 -ITD--FSKRPKKL--KYAKGGAKYIPTSKHEYENTTEGHYDEILTVAASPDGKYVVTGG 255 Query: 332 WDSFLKIWN 340 D L +W+ Sbjct: 256 RDRKLIVWS 264 >3JB9-S nrPDB Length = 488 Score = 38.1 bits (87), Expect = 0.005, Method: Compositional matrix adjust. Identities = 24/105 (22%), Positives = 49/105 (46%), Gaps = 4/105 (3%) Query: 156 QIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVRE 215 + + ++ + C ++ +++ T H + SL++ PD LFV+G + + ++ Sbjct: 308 EYLLAASNEKCYIFSLKSQVYNITVAQH---ITSLAVHPDGNLFVAGLENGELRFFETSS 364 Query: 216 GMCRQTFTGHESDINAICFFPNGN-AFATGSDDATCRLFDLRADQ 259 G F H S + + F NG T +DD+ ++DLR + Sbjct: 365 GNELTKFGPHSSPVKTLQFGENGYWLVVTTNDDSDIFIWDLRKSE 409 Score = 35.4 bits (80), Expect = 0.039, Method: Compositional matrix adjust. Identities = 18/76 (23%), Positives = 38/76 (50%), Gaps = 3/76 (3%) Query: 229 INAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGR-LLLA 287 I ++ P+GN F G ++ R F+ + EL + + + ++ F ++G L++ Sbjct: 336 ITSLAVHPDGNLFVAGLENGELRFFETSSGNELTKFGPHS--SPVKTLQFGENGYWLVVT 393 Query: 288 GYDDFNCNVWDALKAD 303 DD + +WD K++ Sbjct: 394 TNDDSDIFIWDLRKSE 409 Score = 31.2 bits (69), Expect = 0.63, Method: Compositional matrix adjust. Identities = 25/113 (22%), Positives = 49/113 (43%), Gaps = 7/113 (6%) Query: 229 INAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAG 288 +N + P+G S++ C +F L++ +T + ITS++ G L +AG Sbjct: 298 VNFLQAHPSGEYLLAASNEK-CYIFSLKSQVYNITVAQH-----ITSLAVHPDGNLFVAG 351 Query: 289 YDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGM-AVATGSWDSFLKIWN 340 ++ ++ + H + V L ++G V T + DS + IW+ Sbjct: 352 LENGELRFFETSSGNELTKFGPHSSPVKTLQFGENGYWLVVTTNDDSDIFIWD 404 >6E29-D nrPDB Length = 345 Score = 38.1 bits (87), Expect = 0.005, Method: Compositional matrix adjust. Identities = 22/75 (29%), Positives = 36/75 (48%), Gaps = 1/75 (1%) Query: 143 TGYLSCCRFLDDNQIVTSSG-DTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVS 201 +G+ +C RF + S D T +WD+ET GH+ ++ SLS + R +S Sbjct: 25 SGHSTCVRFNRKGDFLASGRVDGTVVIWDLETMGVARKLRGHSKNITSLSWSRCGRYLLS 84 Query: 202 GACDASAKLWDVREG 216 LWD+++G Sbjct: 85 ACQGWKVILWDLQDG 99 Score = 34.3 bits (77), Expect = 0.070, Method: Compositional matrix adjust. Identities = 18/54 (33%), Positives = 26/54 (48%) Query: 45 MRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSS 98 M R LRGH I ++ W R L+SA Q K+I+WD + + R+ Sbjct: 57 MGVARKLRGHSKNITSLSWSRCGRYLLSACQGWKVILWDLQDGKRYREVRFRAP 110 Score = 32.0 bits (71), Expect = 0.39, Method: Compositional matrix adjust. Identities = 27/98 (27%), Positives = 45/98 (45%), Gaps = 11/98 (11%) Query: 210 LWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLR---ADQELMTYSH 266 L D E + +GH + + F G+ A+G D T ++DL ++L +S Sbjct: 12 LQDYPENITNTIRSGHST---CVRFNRKGDFLASGRVDGTVVIWDLETMGVARKLRGHSK 68 Query: 267 DNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADR 304 + ITS+S+S+ GR LL+ + +WD R Sbjct: 69 N-----ITSLSWSRCGRYLLSACQGWKVILWDLQDGKR 101 >5CXB-B nrPDB Length = 369 Score = 37.7 bits (86), Expect = 0.007, Method: Compositional matrix adjust. Identities = 15/34 (44%), Positives = 21/34 (61%) Query: 222 FTGHESDINAICFFPNGNAFATGSDDATCRLFDL 255 F GHE + ++ P G A ATG DD T R+++L Sbjct: 17 FRGHEGRVRSVAIDPTGVALATGGDDGTVRVWEL 50 Score = 32.7 bits (73), Expect = 0.21, Method: Compositional matrix adjust. Identities = 23/79 (29%), Positives = 39/79 (49%), Gaps = 11/79 (13%) Query: 176 QTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFT----GHESDINA 231 Q T F GH G V S+++ P +G D + ++W++ G RQ ++ G E+ +N Sbjct: 13 QQTIFRGHEGRVRSVAIDPTGVALATGGDDGTVRVWELLTG--RQVWSVKLNGDEA-VNT 69 Query: 232 ICFFPNGNAF----ATGSD 246 + + P + F A G D Sbjct: 70 VRWRPTKDTFILAAAAGED 88 Score = 30.4 bits (67), Expect = 1.3, Method: Compositional matrix adjust. Identities = 11/34 (32%), Positives = 20/34 (58%) Query: 307 VLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 + GH+ RV + + G+A+ATG D +++W Sbjct: 16 IFRGHEGRVRSVAIDPTGVALATGGDDGTVRVWE 49 >3DW8-B nrPDB Length = 447 Score = 37.4 bits (85), Expect = 0.009, Method: Compositional matrix adjust. Identities = 42/162 (25%), Positives = 59/162 (36%), Gaps = 33/162 (20%) Query: 171 IETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLW------------DVREGMC 218 +E + HT + S+S+ D ++S A D LW D++ Sbjct: 164 VEASPRRIFANAHTYHINSISINSDYETYLS-ADDLRINLWHLEITDRSFNIVDIKPANM 222 Query: 219 RQTFTGHESDINAICFFPNG-NAFATGSDDATCRLFDLRAD------QELMTYSHD---- 267 + I A F PN N F S T RL D+RA +L D Sbjct: 223 EEL----TEVITAAEFHPNSCNTFVYSSSKGTIRLCDMRASALCDRHSKLFEEPEDPSNR 278 Query: 268 ----NIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRA 305 II I+ V FS SGR ++ D + VWD +R Sbjct: 279 SFFSEIISSISDVKFSHSGRYMMTR-DYLSVKVWDLNMENRP 319 >5TF2-A nrPDB Length = 407 Score = 37.0 bits (84), Expect = 0.012, Method: Compositional matrix adjust. Identities = 18/63 (28%), Positives = 31/63 (49%), Gaps = 2/63 (3%) Query: 151 FLDDNQIVTSSG-DTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAK 209 F DN ++ + G D +W + + ++ F H G++ L+L PD +L G D A Sbjct: 180 FNHDNTLLATGGTDGYVRVWKVPSLEKVLEFKAHEGEIEDLALGPDGKLVTVGR-DLKAS 238 Query: 210 LWD 212 +W Sbjct: 239 VWQ 241 Score = 30.8 bits (68), Expect = 0.83, Method: Compositional matrix adjust. Identities = 14/52 (26%), Positives = 20/52 (38%) Query: 195 DTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSD 246 D L +G D ++W V F HE +I + P+G G D Sbjct: 183 DNTLLATGGTDGYVRVWKVPSLEKVLEFKAHEGEIEDLALGPDGKLVTVGRD 234 >3JRP-A nrPDB Length = 379 Score = 36.2 bits (82), Expect = 0.021, Method: Compositional matrix adjust. Identities = 51/225 (22%), Positives = 85/225 (37%), Gaps = 47/225 (20%) Query: 50 TLRGHLAKIYAMHWGTDS--RLLVSASQDGKLIIWDS----YTTNKVHAIPLRSSWVMTC 103 TL GH ++ + W +L S S DGK++IW ++ VHA+ S+ V + Sbjct: 50 TLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAV--HSASVNSV 107 Query: 104 AYAPS--GNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSS 161 +AP G + D S+ K G T + +D + I +S Sbjct: 108 QWAPHEYGPLLLVASSDGKVSVVEFKEN-----------GTTSPI----IIDAHAIGVNS 152 Query: 162 GDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLW----DVREGM 217 A W T ++ G ++R FV+G D K+W D + + Sbjct: 153 -----ASWAPATIEEDGEHNG----------TKESRKFVTGGADNLVKIWKYNSDAQTYV 197 Query: 218 CRQTFTGHESDINAICFFPN---GNAFATGSDDATCRLFDLRADQ 259 T GH + + + P + A+ S D TC ++ +Q Sbjct: 198 LESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQ 242 >4BZK-B nrPDB Length = 297 Score = 36.2 bits (82), Expect = 0.021, Method: Compositional matrix adjust. Identities = 51/225 (22%), Positives = 85/225 (37%), Gaps = 47/225 (20%) Query: 50 TLRGHLAKIYAMHWGTDS--RLLVSASQDGKLIIWDS----YTTNKVHAIPLRSSWVMTC 103 TL GH ++ + W +L S S DGK++IW ++ VHA+ S+ V + Sbjct: 48 TLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAV--HSASVNSV 105 Query: 104 AYAPS--GNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSS 161 +AP G + D S+ K G T + +D + I +S Sbjct: 106 QWAPHEYGPLLLVASSDGKVSVVEFKEN-----------GTTSPI----IIDAHAIGVNS 150 Query: 162 GDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLW----DVREGM 217 A W T ++ G ++R FV+G D K+W D + + Sbjct: 151 -----ASWAPATIEEDGEHNG----------TKESRKFVTGGADNLVKIWKYNSDAQTYV 195 Query: 218 CRQTFTGHESDINAICFFPN---GNAFATGSDDATCRLFDLRADQ 259 T GH + + + P + A+ S D TC ++ +Q Sbjct: 196 LESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQ 240 >5N4A-A nrPDB Length = 771 Score = 35.4 bits (80), Expect = 0.034, Method: Compositional matrix adjust. Identities = 36/199 (18%), Positives = 70/199 (35%), Gaps = 48/199 (24%) Query: 46 RTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAY 105 R +++ GH ++ W D L +A +DG + IW Sbjct: 95 RVEKSIEGHKGACISLRWSYDGTALATAGEDGSVKIW----------------------- 131 Query: 106 APSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTT 165 +R G +R + A Y S D +Q+ +G + Sbjct: 132 ----------------------SRNGMLRSTLAQADSPVY-SIVWAYDCDQLCYCTG-SN 167 Query: 166 CALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGH 225 + + + + + H G V+ + +P L ++G D K+WD + Q+ Sbjct: 168 VVIKSLSSNAKQNAWKAHDGVVLKVDWSPINHLIITGGEDCKYKVWDSFGRLLFQSGL-F 226 Query: 226 ESDINAICFFPNGNAFATG 244 + + ++ + P+G FA G Sbjct: 227 DYPVTSVAWAPSGELFAVG 245 Score = 34.3 bits (77), Expect = 0.076, Method: Compositional matrix adjust. Identities = 18/69 (26%), Positives = 33/69 (47%), Gaps = 1/69 (1%) Query: 52 RGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNY 111 + H + + W + L+++ +D K +WDS+ + L V + A+APSG Sbjct: 183 KAHDGVVLKVDWSPINHLIITGGEDCKYKVWDSFGRLLFQS-GLFDYPVTSVAWAPSGEL 241 Query: 112 VACGGLDNI 120 A GG + + Sbjct: 242 FAVGGFNTL 250 >6CB1-s nrPDB Length = 569 Score = 35.4 bits (80), Expect = 0.035, Method: Compositional matrix adjust. Identities = 14/44 (31%), Positives = 25/44 (56%) Query: 218 CRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQEL 261 C + GH+ + + P+G ATGSDD T R++++ +E+ Sbjct: 191 CSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREV 234 Score = 33.1 bits (74), Expect = 0.16, Method: Compositional matrix adjust. Identities = 22/80 (27%), Positives = 38/80 (47%), Gaps = 10/80 (12%) Query: 177 TTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREG--MCRQTFTGHESD----IN 230 +T + GH G V +LS+ P +G+ D + ++W++ G + R T E + I Sbjct: 192 STIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIE 251 Query: 231 AICFFPNGN----AFATGSD 246 I + P+ N A A G + Sbjct: 252 CIEWNPDANNGILAVAVGEN 271 Score = 30.4 bits (67), Expect = 1.0, Method: Compositional matrix adjust. Identities = 12/34 (35%), Positives = 20/34 (58%) Query: 307 VLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 + AGH +V L + G+ +ATGS D +++W Sbjct: 194 IYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWE 227 >3JRO-A nrPDB Length = 753 Score = 35.4 bits (80), Expect = 0.038, Method: Compositional matrix adjust. Identities = 51/216 (23%), Positives = 82/216 (37%), Gaps = 47/216 (21%) Query: 50 TLRGHLAKIYAMHWGTDS--RLLVSASQDGKLIIWDS----YTTNKVHAIPLRSSWVMTC 103 TL GH ++ + W +L S S DGK++IW ++ VHA+ S+ V + Sbjct: 48 TLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAV--HSASVNSV 105 Query: 104 AYAPS--GNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSS 161 +AP G + D S+ K G T + +D + I +S Sbjct: 106 QWAPHEYGPLLLVASSDGKVSVVEFKEN-----------GTTSPI----IIDAHAIGVNS 150 Query: 162 GDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLW----DVREGM 217 A + E G+ H G ++R FV+G D K+W D + + Sbjct: 151 ASWAPATIE-EDGE-------HNG-------TKESRKFVTGGADNLVKIWKYNSDAQTYV 195 Query: 218 CRQTFTGHESDINAICFFPN---GNAFATGSDDATC 250 T GH + + + P + A+ S D TC Sbjct: 196 LESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTC 231 >6C0F-s nrPDB Length = 807 Score = 35.4 bits (80), Expect = 0.040, Method: Compositional matrix adjust. Identities = 14/44 (31%), Positives = 25/44 (56%) Query: 218 CRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQEL 261 C + GH+ + + P+G ATGSDD T R++++ +E+ Sbjct: 429 CSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREV 472 Score = 33.5 bits (75), Expect = 0.14, Method: Compositional matrix adjust. Identities = 22/80 (27%), Positives = 38/80 (47%), Gaps = 10/80 (12%) Query: 177 TTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREG--MCRQTFTGHESD----IN 230 +T + GH G V +LS+ P +G+ D + ++W++ G + R T E + I Sbjct: 430 STIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIE 489 Query: 231 AICFFPNGN----AFATGSD 246 I + P+ N A A G + Sbjct: 490 CIEWNPDANNGILAVAVGEN 509 Score = 30.8 bits (68), Expect = 0.93, Method: Compositional matrix adjust. Identities = 12/33 (36%), Positives = 20/33 (60%) Query: 307 VLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIW 339 + AGH +V L + G+ +ATGS D +++W Sbjct: 432 IYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVW 464 >6EM1-m nrPDB Length = 807 Score = 35.0 bits (79), Expect = 0.047, Method: Compositional matrix adjust. Identities = 14/44 (31%), Positives = 25/44 (56%) Query: 218 CRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQEL 261 C + GH+ + + P+G ATGSDD T R++++ +E+ Sbjct: 429 CSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREV 472 Score = 33.5 bits (75), Expect = 0.15, Method: Compositional matrix adjust. Identities = 22/80 (27%), Positives = 38/80 (47%), Gaps = 10/80 (12%) Query: 177 TTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREG--MCRQTFTGHESD----IN 230 +T + GH G V +LS+ P +G+ D + ++W++ G + R T E + I Sbjct: 430 STIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIE 489 Query: 231 AICFFPNGN----AFATGSD 246 I + P+ N A A G + Sbjct: 490 CIEWNPDANNGILAVAVGEN 509 Score = 30.8 bits (68), Expect = 0.86, Method: Compositional matrix adjust. Identities = 12/33 (36%), Positives = 20/33 (60%) Query: 307 VLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIW 339 + AGH +V L + G+ +ATGS D +++W Sbjct: 432 IYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVW 464 >5MC6-j nrPDB Length = 397 Score = 34.3 bits (77), Expect = 0.086, Method: Compositional matrix adjust. Identities = 29/119 (24%), Positives = 49/119 (41%), Gaps = 20/119 (16%) Query: 242 ATGSDDATCRLFDLRADQELMTYSHDNIIC----GITSVSFSKSGRLLLAGYDD--FNC- 294 ATG ++ T ++ +L + L + + + I SV FS G LL +D F C Sbjct: 201 ATGFNNGTVQISELSTLRPLYNFESQHSMINNSNSIRSVKFSPQGSLLAIAHDSNSFGCI 260 Query: 295 NVWDALKADRAGVLA-------------GHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 +++ +R G L+ H + V L D G + + WD L+ W+ Sbjct: 261 TLYETEFGERIGSLSVPTHSSQASLGEFAHSSWVMSLSFNDSGETLCSAGWDGKLRFWD 319 Score = 29.3 bits (64), Expect = 2.9, Method: Compositional matrix adjust. Identities = 12/35 (34%), Positives = 20/35 (57%) Query: 96 RSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTRE 130 SSWVM+ ++ SG + G D +++KT+E Sbjct: 290 HSSWVMSLSFNDSGETLCSAGWDGKLRFWDVKTKE 324 >4YHC-A nrPDB Length = 468 Score = 33.5 bits (75), Expect = 0.13, Method: Compositional matrix adjust. Identities = 20/86 (23%), Positives = 38/86 (44%), Gaps = 5/86 (5%) Query: 183 HTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESD--INAICFFPNGNA 240 H D++ ++++ + + F S D S +WD+R+ + + + + AI P GN Sbjct: 29 HQLDILKIAVSENYKTFASVGLDRSLVVWDLRQWCTKLVLSKEQMPRTLKAIALDPQGNY 88 Query: 241 FATGSDDATCRLFDLRADQELMTYSH 266 + S D LF L + + H Sbjct: 89 VSLFSKDT---LFILNVESPSLMLQH 111 >3JZG-A nrPDB Length = 402 Score = 33.1 bits (74), Expect = 0.17, Method: Compositional matrix adjust. Identities = 32/121 (26%), Positives = 49/121 (40%), Gaps = 13/121 (10%) Query: 102 TCAYAPSGN----YVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRF--LDDN 155 TCA+ N +A G I I N T ++ + GH ++ +F D N Sbjct: 110 TCAWTYDSNTSHPLLAVAGSRGIIRIINPIT----MQCIKHYVGHGNAINELKFHPRDPN 165 Query: 156 QIVTSSGDTTCALWDIETGQQTTTF---TGHTGDVMSLSLAPDTRLFVSGACDASAKLWD 212 +++ S D LW+I+T F GH +V+S +S D S KLW Sbjct: 166 LLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWR 225 Query: 213 V 213 + Sbjct: 226 I 226 >5K19-A nrPDB Length = 569 Score = 33.1 bits (74), Expect = 0.18, Method: Compositional matrix adjust. Identities = 42/196 (21%), Positives = 73/196 (37%), Gaps = 17/196 (8%) Query: 150 RFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSL--------SLAPDTRLFVS 201 + ++ +++ S TC W G ++ H+ M L + AP +L Sbjct: 139 KLFNEERLIDKS-RVTCVKW--VPGSESLFLVAHSSGNMYLYNVEHTCGTTAPHYQLLKQ 195 Query: 202 GACDA--SAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQ 259 G A + K R + + T E +N F P+G A S D R+F+ D Sbjct: 196 GESFAVHTCKSKSTRNPLLKWTVG--EGALNEFAFSPDGKFLACVSQDGFLRVFNF--DS 251 Query: 260 ELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLG 319 + + + G+ V +S G+ ++ G +D VW + GH + VS + Sbjct: 252 VELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVA 311 Query: 320 VTDDGMAVATGSWDSF 335 +V G F Sbjct: 312 FDPYTTSVEEGDPMEF 327 Score = 32.7 bits (73), Expect = 0.25, Method: Compositional matrix adjust. Identities = 21/91 (23%), Positives = 47/91 (51%), Gaps = 8/91 (8%) Query: 63 WGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSW--VMTCAYAPSGNYVACGGLDNI 120 + D + L SQDG L +++ + + ++H ++S + ++ ++P G Y+ GG D++ Sbjct: 228 FSPDGKFLACVSQDGFLRVFN-FDSVELHGT-MKSYFGGLLCVCWSPDGKYIVTGGEDDL 285 Query: 121 CSIYNLKTREGNVRVSRELAGHTGYLSCCRF 151 ++++ + RV GH ++S F Sbjct: 286 VTVWSFV----DCRVIARGHGHKSWVSVVAF 312 Score = 29.6 bits (65), Expect = 1.8, Method: Compositional matrix adjust. Identities = 23/94 (24%), Positives = 37/94 (39%), Gaps = 5/94 (5%) Query: 104 AYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSC-CRFLDDNQIVTSSG 162 A++P G ++AC D ++N + V + + + G L C C D IVT Sbjct: 227 AFSPDGKFLACVSQDGFLRVFNFDS----VELHGTMKSYFGGLLCVCWSPDGKYIVTGGE 282 Query: 163 DTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDT 196 D +W + GH V ++ P T Sbjct: 283 DDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYT 316 >6BX3-B nrPDB Length = 412 Score = 33.1 bits (74), Expect = 0.19, Method: Compositional matrix adjust. Identities = 21/77 (27%), Positives = 37/77 (48%), Gaps = 8/77 (10%) Query: 234 FFPNGNAFATGSDDATCRLFDLRADQEL-----MTYSHDNIICGITSVSFSKSGRLLLAG 288 F P G+ A G + ++D+ + + M +H + ITS+++S GRLLL Sbjct: 33 FSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAH---VRPITSIAWSPDGRLLLTS 89 Query: 289 YDDFNCNVWDALKADRA 305 D++ +WD K + Sbjct: 90 SRDWSIKLWDLSKPSKP 106 Score = 31.2 bits (69), Expect = 0.69, Method: Compositional matrix adjust. Identities = 15/47 (31%), Positives = 26/47 (55%), Gaps = 4/47 (8%) Query: 51 LRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRS 97 L H+ I ++ W D RLL+++S+D + +WD +K PL+ Sbjct: 67 LGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSK----PLKE 109 Score = 30.8 bits (68), Expect = 0.86, Method: Compositional matrix adjust. Identities = 12/32 (37%), Positives = 20/32 (62%) Query: 182 GHTGDVMSLSLAPDTRLFVSGACDASAKLWDV 213 H + S++ +PD RL ++ + D S KLWD+ Sbjct: 69 AHVRPITSIAWSPDGRLLLTSSRDWSIKLWDL 100 Score = 30.8 bits (68), Expect = 0.88, Method: Compositional matrix adjust. Identities = 21/79 (26%), Positives = 37/79 (46%), Gaps = 4/79 (5%) Query: 94 PLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLD 153 PLR+ ++P G+Y+A G + IY++ T L H ++ + Sbjct: 25 PLRTE---CLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSP 81 Query: 154 DNQ-IVTSSGDTTCALWDI 171 D + ++TSS D + LWD+ Sbjct: 82 DGRLLLTSSRDWSIKLWDL 100 >5FA5-B nrPDB Length = 367 Score = 32.7 bits (73), Expect = 0.22, Method: Compositional matrix adjust. Identities = 21/84 (25%), Positives = 37/84 (44%), Gaps = 8/84 (9%) Query: 243 TGSDDATCRLFDLRADQELMT-----YSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVW 297 SD L++L ++ L+ Y HD+I+ ++VS SG ++G D VW Sbjct: 121 VASDSGAVELWELDENETLIVSKFCKYEHDDIV---STVSVLSSGTQAVSGSKDICIKVW 177 Query: 298 DALKADRAGVLAGHDNRVSCLGVT 321 D + H +V+C+ + Sbjct: 178 DLAQQVVLSSYRAHAAQVTCVAAS 201 Score = 31.2 bits (69), Expect = 0.73, Method: Compositional matrix adjust. Identities = 23/115 (20%), Positives = 54/115 (46%), Gaps = 5/115 (4%) Query: 151 FLDDNQIVTSSGDTTCALWDIETGQQ--TTTFTGHTGD--VMSLSLAPDTRLFVSGACDA 206 ++ + I+ +S LW+++ + + F + D V ++S+ VSG+ D Sbjct: 113 WVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDI 172 Query: 207 SAKLWDVREGMCRQTFTGHESDINAICFFPNGNA-FATGSDDATCRLFDLRADQE 260 K+WD+ + + ++ H + + + P+ ++ F + S+D L+D R + Sbjct: 173 CIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKP 227 Score = 29.6 bits (65), Expect = 1.8, Method: Compositional matrix adjust. Identities = 34/177 (19%), Positives = 65/177 (36%), Gaps = 10/177 (5%) Query: 100 VMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSC--CRFLDDNQI 157 V T + SG G D +++L + V H ++C D+ Sbjct: 153 VSTVSVLSSGTQAVSGSKDICIKVWDLAQQ----VVLSSYRAHAAQVTCVAASPHKDSVF 208 Query: 158 VTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLA---PDTRLFVSGACDASAKLWDVR 214 ++ S D LWD + + + SLA + +FV G + + L D + Sbjct: 209 LSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTK 268 Query: 215 EGMCRQTFTGHESDINAICFFPNGNAF-ATGSDDATCRLFDLRADQELMTYSHDNII 270 C + H + + F P+ F A+ S+D + + D + + +H + + Sbjct: 269 STSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQAHRDFV 325 >1ZUW-A nrPDB Length = 272 Score = 32.7 bits (73), Expect = 0.24, Method: Compositional matrix adjust. Identities = 18/63 (28%), Positives = 32/63 (50%), Gaps = 8/63 (12%) Query: 150 RFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAK 209 R++ ++ + SSGD ET ++ +T + G + +APD + +GA D AK Sbjct: 197 RYMGEHVNIISSGD--------ETAREVSTILSYKGLLNQSPIAPDHQFLTTGARDQFAK 248 Query: 210 LWD 212 + D Sbjct: 249 IAD 251 >3F3P-A nrPDB Length = 351 Score = 32.7 bits (73), Expect = 0.26, Method: Compositional matrix adjust. Identities = 67/286 (23%), Positives = 117/286 (40%), Gaps = 42/286 (14%) Query: 52 RGHLAKIYAMHWGTDS--RLLVSASQDGKLIIWDSYTT---------NKVHAIPLRSSWV 100 R H + I A+ W + R++ SAS D + +W+ NK+ + + Sbjct: 54 RAHDSSIVAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSL 113 Query: 101 MTCAYAPS--GNYVACGGLDNICSIYN----------LKTREGNVRVSRELAGHTGY--- 145 + +AP+ G +AC G D I +Y+ T E V +S A H Sbjct: 114 YSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKV-LSIPPANHLQSDFC 172 Query: 146 LSCC--RFLDDNQIVTSSGDTTCALWDIETGQQ--TTTFTGHTGDVMSLSLAPDT----R 197 LS C RF ++ S+ + + G+ GH + S+S AP + Sbjct: 173 LSWCPSRF-SPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQ 231 Query: 198 LFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAF--ATG-SDDATCRLFD 254 L +G D +++ + E + ES N+ F + + A G SD T + Sbjct: 232 LIATGCKDGRIRIFKITEKLS--PLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAE 289 Query: 255 LRADQELMTYS-HDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDA 299 L+++ ++ S HD+ + SVS++ +G +L + DD +W A Sbjct: 290 LQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKA 335 >3I2N-A nrPDB Length = 357 Score = 32.3 bits (72), Expect = 0.32, Method: Compositional matrix adjust. Identities = 44/210 (20%), Positives = 78/210 (37%), Gaps = 38/210 (18%) Query: 100 VMTCAYAP-SGNYVACGGLDNICSIYNL-KTREGNVRVSRELAGHTGYLSCCRF----LD 153 V C + P S +V G + L + + G++++ RE+ + C F L Sbjct: 21 VFDCKWVPCSAKFVTMGNFARGTGVIQLYEIQHGDLKLLREIE-KAKPIKCGTFGATSLQ 79 Query: 154 DNQIVTSSGDTTCALWDIETGQQTT-TFTGHTGDV---------MSLSLAPDTRLFVSGA 203 + T +W++E + + GH + AP+ V+G+ Sbjct: 80 QRYLATGDFGGNLHIWNLEAPEMPVYSVKGHKEIINAIDGIGGLGIGEGAPE---IVTGS 136 Query: 204 CDASAKLWDVRE-----GMCRQTFTGHESDINAICFFPNGNAF-------ATGSDDATCR 251 D + K+WD R+ ++ D + F GNA+ G D+ + Sbjct: 137 RDGTVKVWDPRQKDDPVANMEPVQGENKRDCWTVAF---GNAYNQEERVVCAGYDNGDIK 193 Query: 252 LFDLRADQELMTYSHDNIICGITSVSFSKS 281 LFDLR + NI G+ S+ F + Sbjct: 194 LFDLR---NMALRWETNIKNGVCSLEFDRK 220 >3CLR-D nrPDB Length = 321 Score = 32.3 bits (72), Expect = 0.32, Method: Compositional matrix adjust. Identities = 47/234 (20%), Positives = 85/234 (36%), Gaps = 37/234 (15%) Query: 24 ACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWD 83 A + ++ + +++D +G +T G +Y + + D + + K+ + Sbjct: 85 AAHNPSVVLLPHSVDSLGYASSLASKTGYGFATDVYIVEYQGDELVATRGGYNQKVNVEV 144 Query: 84 SYTTNKVHAIPLRSSW----------VMTCAYAPS-------GNYVACGG--------LD 118 + + +R S V++ APS +YV GG +D Sbjct: 145 DFPGKSTVVLTIRPSVFKPLEGAGSPVVSNVDAPSVQSRSQNKDYVEVGGGNDIDITTVD 204 Query: 119 NICSIYNLKTREGNVRVSRELAGHTGYLSCCR-------FLDDNQIVTSSGDT--TCALW 169 I SI E NV RELA G CC +L ++ V SG +C L+ Sbjct: 205 FIMSIGRGIGEETNVEQFRELADEAGATLCCSAPIADAGWLPKSRQVGQSGKVVGSCKLY 264 Query: 170 ---DIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQ 220 I Q H +++++ P +F A ++D+ E + Q Sbjct: 265 VAMGISGSIQHMAGMKHVPTIIAVNTDPGASIFTIAKYGIVADIFDIEEELKAQ 318 >5OV3-A nrPDB Length = 381 Score = 32.0 bits (71), Expect = 0.36, Method: Compositional matrix adjust. Identities = 22/74 (29%), Positives = 28/74 (37%), Gaps = 1/74 (1%) Query: 163 DTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTF 222 D +WD T + H V SL + D VS + D WDV G C Q F Sbjct: 46 DGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRF 105 Query: 223 TGHESDINAICFFP 236 S I + + P Sbjct: 106 R-FPSPILKVQYHP 118 Score = 31.2 bits (69), Expect = 0.66, Method: Compositional matrix adjust. Identities = 43/210 (20%), Positives = 85/210 (40%), Gaps = 17/210 (8%) Query: 98 SWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYL-SCCRFLDDNQ 156 S +TC + G +A G D I++ TR +++ ++ H + S C D ++ Sbjct: 26 SMALTCTFNRWGTLLAVGCNDGRIVIWDFLTR----GIAKIISAHIHPVCSLCWSRDGHK 81 Query: 157 IVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAP-DTRLFVSGACDASAKLWDVRE 215 +V++S D + WD+ +G F ++ + P D + ++ + + + Sbjct: 82 LVSASTDNIVSQWDVLSGDCDQRFR-FPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSD 140 Query: 216 GMCRQTFTGHESDINAICFFP-NGNAFATGSDDATCRLFDLRADQELMTYSHDNIICG-- 272 +SD+N + F G TG +A ++ L+ D + + S + G Sbjct: 141 SKHVVLPVDDDSDLNVVASFDRRGEYIYTG--NAKGKILVLKTDSQDLVASF-RVTTGTS 197 Query: 273 ----ITSVSFSKSGRLLLAGYDDFNCNVWD 298 I S+ F++ G L D V+D Sbjct: 198 NTTAIKSIEFARKGSCFLINTADRIIRVYD 227 Score = 29.6 bits (65), Expect = 1.8, Method: Compositional matrix adjust. Identities = 18/64 (28%), Positives = 29/64 (45%), Gaps = 3/64 (4%) Query: 63 WGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICS 122 WGT LL DG+++IWD T I V + ++ G+ + DNI S Sbjct: 36 WGT---LLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVS 92 Query: 123 IYNL 126 +++ Sbjct: 93 QWDV 96 >4PSX-B nrPDB Length = 401 Score = 32.0 bits (71), Expect = 0.44, Method: Compositional matrix adjust. Identities = 25/112 (22%), Positives = 44/112 (39%), Gaps = 19/112 (16%) Query: 108 SGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLD--DNQIVTSSGDTT 165 S N +A G+D+ +Y+L+ + + ++GH ++ F D +V+S D Sbjct: 263 SSNLLAAAGMDSYVYLYDLRNMKEPL---HHMSGHEDAVNNLEFSTHVDGVVVSSGSDNR 319 Query: 166 CALWDIET--GQQTT------------TFTGHTGDVMSLSLAPDTRLFVSGA 203 +WD++ +QT GH V L P V+ A Sbjct: 320 LMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASA 371 Score = 31.6 bits (70), Expect = 0.54, Method: Compositional matrix adjust. Identities = 45/205 (21%), Positives = 79/205 (38%), Gaps = 44/205 (21%) Query: 126 LKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTG 185 L +R ++ + + GY L ++++ S D T ALW++ +G T Sbjct: 145 LYSRSEGLQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWN 204 Query: 186 DVMSLSLAPDTR-------LFVSGACDASAKLWDVREG-------MCRQTFTGHESDINA 231 D+ S + D + LF + + D+ K+ DVR C Q F N Sbjct: 205 DLHS-DIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPF-------NT 256 Query: 232 ICF-FPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYD 290 + F + N A D+ L+DLR +E + + ++G++ Sbjct: 257 LAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHH---------------------MSGHE 295 Query: 291 DFNCNVWDALKADRAGVLAGHDNRV 315 D N+ + D V +G DNR+ Sbjct: 296 DAVNNLEFSTHVDGVVVSSGSDNRL 320 >3EI3-B nrPDB Length = 383 Score = 31.6 bits (70), Expect = 0.52, Method: Compositional matrix adjust. Identities = 24/99 (24%), Positives = 42/99 (42%), Gaps = 22/99 (22%) Query: 198 LFVSGACDASAKLWDVREGMCRQTFTG---HESDINAICFFPNGNAFATGSDDATCRLFD 254 L + + DA+ KLWD+R + ++ HE +NA F P D+T Sbjct: 219 LMATSSVDATVKLWDLRNIKDKNSYIAEMPHEKPVNAAYFNPT---------DST----- 264 Query: 255 LRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFN 293 +L+T N I +S +SK ++++ + F Sbjct: 265 -----KLLTTDQRNEIRVYSSYDWSKPDQIIIHPHRQFQ 298 >1Z68-A nrPDB Length = 719 Score = 31.2 bits (69), Expect = 0.60, Method: Compositional matrix adjust. Identities = 22/64 (34%), Positives = 32/64 (50%), Gaps = 5/64 (7%) Query: 151 FLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLS---LAPDTRLFVSGACDAS 207 ++ + + S D L++IETGQ T + T ++ S L+PD R FV D S Sbjct: 23 WISGQEYLHQSADNNIVLYNIETGQSYTILSNRTMKSVNASNYGLSPD-RQFVYLESDYS 81 Query: 208 AKLW 211 KLW Sbjct: 82 -KLW 84 >5WLC-LN nrPDB Length = 776 Score = 31.2 bits (69), Expect = 0.68, Method: Compositional matrix adjust. Identities = 19/63 (30%), Positives = 27/63 (42%), Gaps = 5/63 (7%) Query: 187 VMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFP---NGNAFAT 243 V S+ P T SG S K WD + Q+F H++D+ +C N F+ Sbjct: 241 VWSVIYLPRTDQIASGDSTGSIKFWDFQFATLNQSFKAHDADV--LCLTTDTDNNYVFSA 298 Query: 244 GSD 246 G D Sbjct: 299 GVD 301 Score = 27.7 bits (60), Expect = 7.2, Method: Compositional matrix adjust. Identities = 22/93 (23%), Positives = 37/93 (39%), Gaps = 14/93 (15%) Query: 160 SSGDTTCAL--WDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGM 217 +SGD+T ++ WD + +F H DV+ L+ D S D K++ + Sbjct: 254 ASGDSTGSIKFWDFQFATLNQSFKAHDADVLCLTTDTDNNYVFSAGVD--RKIFQFSQNT 311 Query: 218 CRQTFTG----------HESDINAICFFPNGNA 240 + H +DI AIC + + A Sbjct: 312 NKSQKNNRWVNSSNRLLHGNDIRAICAYQSKGA 344 >5AMS-A nrPDB Length = 431 Score = 31.2 bits (69), Expect = 0.68, Method: Compositional matrix adjust. Identities = 40/168 (23%), Positives = 68/168 (40%), Gaps = 27/168 (16%) Query: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLII---------WD-SYTTNKVHAIPLRSSW 99 TL G+ + + + ++ LV+A GK+++ W + +V I W Sbjct: 104 TLTGYGESVISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEI----VW 159 Query: 100 VMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDN---- 155 + T + A G D Y + ++G++ H S F++ + Sbjct: 160 LKT--HPTIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGEN 217 Query: 156 --QIVTSSGDTTCALWDIETGQQTTTFT-----GHTGDVMSLSLAPDT 196 ++VT S D+T W+ TGQQ T G +SLSLAP+T Sbjct: 218 TLELVTCSLDSTIVAWNCFTGQQLFKITQAEIKGLEAPWISLSLAPET 265 >5GRS-A nrPDB Length = 396 Score = 30.8 bits (68), Expect = 0.82, Method: Compositional matrix adjust. Identities = 19/86 (22%), Positives = 37/86 (43%), Gaps = 5/86 (5%) Query: 183 HTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESD--INAICFFPNGNA 240 H D++ ++++ + + F S D +WD+R+ + + + + AI P GN Sbjct: 29 HQLDILKIAVSENYKTFASVGLDRCLVVWDLRQWCTKLVLSKEQMPRTLKAIALDPQGNY 88 Query: 241 FATGSDDATCRLFDLRADQELMTYSH 266 + S D LF L + + H Sbjct: 89 VSLFSKDT---LFILNVESPSLMLQH 111 >5YZG-2 nrPDB Length = 646 Score = 30.8 bits (68), Expect = 0.84, Method: Compositional matrix adjust. Identities = 19/59 (32%), Positives = 31/59 (52%), Gaps = 2/59 (3%) Query: 157 IVTSSGDTTCALWD-IETGQQ-TTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDV 213 I+T+S D W IE G + F H G + S++++ + LF S D + K++DV Sbjct: 104 IITASHDGHVKFWKKIEEGIEFVKHFRSHLGVIESIAVSSEGALFCSVGDDKAMKVFDV 162 Score = 29.3 bits (64), Expect = 2.6, Method: Compositional matrix adjust. Identities = 18/72 (25%), Positives = 32/72 (44%), Gaps = 2/72 (2%) Query: 186 DVMSLSLAPDTRLFVSGACDASAKLWD-VREGM-CRQTFTGHESDINAICFFPNGNAFAT 243 DV++ + T ++ + D K W + EG+ + F H I +I G F + Sbjct: 91 DVITHVVCTKTDFIITASHDGHVKFWKKIEEGIEFVKHFRSHLGVIESIAVSSEGALFCS 150 Query: 244 GSDDATCRLFDL 255 DD ++FD+ Sbjct: 151 VGDDKAMKVFDV 162 >3DWL-C nrPDB Length = 377 Score = 30.0 bits (66), Expect = 1.4, Method: Compositional matrix adjust. Identities = 39/173 (22%), Positives = 67/173 (38%), Gaps = 34/173 (19%) Query: 43 IQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRS----- 97 + +R LR + I ++ W ++ LL + D K + +Y + V A P S Sbjct: 137 VSKHLKRPLR---STILSLDWHPNNVLLAAGCADRKAYVLSAYVRD-VDAKPEASVWGSR 192 Query: 98 -------------SWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTG 144 WV ++PSGN +A G D+ +I E R + Sbjct: 193 LPFNTVCAEYPSGGWVHAVGFSPSGNALAYAGHDSSVTIAYPSAPEQPPRALITVKLSQL 252 Query: 145 YLSCCRFLDDNQIVTSSGDTTCAL-------W----DIETGQQTTTFTGHTGD 186 L + +++ IV + + + L W D++ G T+FT HTG+ Sbjct: 253 PLRSLLWANESAIVAAGYNYSPILLQGNESGWAHTRDLDAGTSKTSFT-HTGN 304 >3W15-A nrPDB Length = 368 Score = 29.6 bits (65), Expect = 2.1, Method: Compositional matrix adjust. Identities = 21/82 (25%), Positives = 34/82 (41%), Gaps = 2/82 (2%) Query: 154 DNQIVTSSGDTTCALWDIETGQ-QTTTFTGHTGDVMSLSLAPDTRL-FVSGACDASAKLW 211 +NQ++ + GD T L+D + F H +V S + R F+S + D S K+W Sbjct: 75 ENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIW 134 Query: 212 DVREGMCRQTFTGHESDINAIC 233 T T +I + Sbjct: 135 SPLRKQSLMTLTPRPLEITKMV 156 >5WLC-LV nrPDB Length = 707 Score = 28.9 bits (63), Expect = 3.0, Method: Compositional matrix adjust. Identities = 32/144 (22%), Positives = 60/144 (41%), Gaps = 15/144 (10%) Query: 69 LLVSASQDGKLIIWDSYTTNKVHAIPL------RSSWVMTCAYAPSGNYVACGGLDNICS 122 LL + ++ + WD + ++V + L R V T ++ G ACG + Sbjct: 194 LLAAGTETNVVEFWDPRSRSRVSKLYLENNIDNRPFQVTTTSFRNDGLTFACGTSNGYSY 253 Query: 123 IYNLKTREGNVRVSRELAGHTGYLSCCRFLD----DNQIVTSSGDTTCALWDIETGQQTT 178 IY+L+T E ++ + G+ + +LD +N+IVT +WD G+ Sbjct: 254 IYDLRTSEPSIIKDQ---GYGFDIKKIIWLDNVGTENKIVTCDK-RIAKIWDRLDGKAYA 309 Query: 179 TFTGHTGDVMSLSLAPDTRLFVSG 202 + D+ + P T +F + Sbjct: 310 SMEPSV-DINDIEHVPGTGMFFTA 332 >5I50-A nrPDB Length = 118 Score = 28.9 bits (63), Expect = 3.1, Method: Compositional matrix adjust. Identities = 12/26 (46%), Positives = 20/26 (76%) Query: 1 MSELDQLRQEAEQLKNQIRDARKACA 26 +SE+D LR++ EQLK+++ R +CA Sbjct: 93 ISEIDLLRKQNEQLKHKLEQLRNSCA 118 >6CHG-D nrPDB Length = 439 Score = 28.9 bits (63), Expect = 3.2, Method: Compositional matrix adjust. Identities = 21/83 (25%), Positives = 38/83 (45%), Gaps = 3/83 (3%) Query: 105 YAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSG-D 163 ++P G+Y+A G + IY++ + + + HT + + +D + + SSG D Sbjct: 35 FSPRGDYLAVGCSNGAIIIYDMDSLKPIAMLGTHSGAHTRSVQSVCWSNDGRYLWSSGRD 94 Query: 164 TTCALWDIETGQQTTTFTGHTGD 186 LWD+ Q T F + D Sbjct: 95 WYAKLWDM--TQPTKCFQQYKFD 115 Score = 28.9 bits (63), Expect = 3.3, Method: Compositional matrix adjust. Identities = 20/83 (24%), Positives = 38/83 (45%), Gaps = 4/83 (4%) Query: 226 ESDINAIC--FFPNGNAFATGSDDATCRLFDLRADQEL-MTYSHDNIIC-GITSVSFSKS 281 E + A+C F P G+ A G + ++D+ + + + M +H + SV +S Sbjct: 25 EVPVAAVCVKFSPRGDYLAVGCSNGAIIIYDMDSLKPIAMLGTHSGAHTRSVQSVCWSND 84 Query: 282 GRLLLAGYDDFNCNVWDALKADR 304 GR L + D+ +WD + + Sbjct: 85 GRYLWSSGRDWYAKLWDMTQPTK 107 >4JNQ-A nrPDB Length = 345 Score = 27.7 bits (60), Expect = 6.8, Method: Compositional matrix adjust. Identities = 29/124 (23%), Positives = 45/124 (36%), Gaps = 6/124 (4%) Query: 53 GHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYV 112 G+ A IYA ++ Q G+L+I +A P++ W+M + N Sbjct: 38 GYTAAIYAARAMLKPVVIAGLQQGGQLMITTDVENYPGYAEPVQGPWMMEQMARQAENVG 97 Query: 113 ACGGLDNICSI------YNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTC 166 A D I + + LK G + L TG + L+ Q G + C Sbjct: 98 AQIVHDIITEVETTVRPFRLKGDSGTIYTCDALIIATGAQAKWLGLESEQTFMGGGVSAC 157 Query: 167 ALWD 170 A D Sbjct: 158 ATCD 161 >2VDU-B nrPDB Length = 450 Score = 27.7 bits (60), Expect = 7.0, Method: Compositional matrix adjust. Identities = 16/48 (33%), Positives = 26/48 (54%), Gaps = 4/48 (8%) Query: 135 VSRELAGHTGYLS--CCRFLDDNQIVTSSGDTTCALWDIETGQQTTTF 180 V + L GH ++S CC D ++++ GD WD +TG+ +TF Sbjct: 233 VDKWLFGHKHFVSSICCG--KDYLLLSAGGDDKIFAWDWKTGKNLSTF 278 >5WLC-LH nrPDB Length = 896 Score = 27.7 bits (60), Expect = 7.8, Method: Compositional matrix adjust. Identities = 15/67 (22%), Positives = 30/67 (44%), Gaps = 2/67 (2%) Query: 49 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTC-AYAP 107 R L+ H+ + ++ + D L+S + + +W TN +P + ++ C P Sbjct: 291 RLLKWHIDSVLSLSFSHDGSYLLSGGWEKVMSLW-QLETNSQQFLPRLNGIIIDCQVLGP 349 Query: 108 SGNYVAC 114 GNY + Sbjct: 350 QGNYYSL 356 >6F1U-h nrPDB Length = 612 Score = 27.7 bits (60), Expect = 7.9, Method: Compositional matrix adjust. Identities = 40/165 (24%), Positives = 68/165 (41%), Gaps = 18/165 (10%) Query: 46 RTRRTLRGHLAKIYAMHW-GT-DSRLLVSASQDGKLIIWD----SYTTNKVHAIPLRSSW 99 RT + H +Y ++ GT ++ L+S S DGK+ W S+ + + + +S Sbjct: 346 RTPLSAAAHTHPVYCVNVVGTQNAHNLISISTDGKICSWSLDMLSHPQDSMELVHKQSKA 405 Query: 100 V-MTCAYAPSG--NYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLS------CCR 150 V +T P G N G + S+Y +S GH G ++ Sbjct: 406 VAVTSMSFPVGDVNNFVVGSEEG--SVYTACRHGSKAGISEMFEGHQGPITGIHCHAAVG 463 Query: 151 FLDDNQI-VTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAP 194 +D + + VTSS D T LW + + +F + G V + +P Sbjct: 464 AVDFSHLFVTSSFDWTVKLWSTKNNKPLYSFEDNAGYVYDVMWSP 508 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 5UZ7-B nrPDB 431 e-121 6N9G-C nrPDB 343 6e-95 1VYH-C nrPDB 293 8e-80 4V7E-Bg nrPDB 291 2e-79 5M25-A nrPDB 285 2e-77 5NNZ-B nrPDB 280 7e-76 5MZH-A nrPDB 273 6e-74 6QX9-4B nrPDB 256 1e-68 2H9P-A nrPDB 254 3e-68 5GAN-H nrPDB 244 3e-65 5FL8-q nrPDB 238 3e-63 6F3T-A nrPDB 236 1e-62 6MZM-G nrPDB 232 1e-61 3DM0-A nrPDB 229 1e-60 6QX9-5O nrPDB 229 1e-60 5NZU-C nrPDB 228 2e-60 6HQA-B nrPDB 227 4e-60 6Q8F-A nrPDB 225 2e-59 5OPT-p nrPDB 221 4e-58 4V8M-A7 nrPDB 219 1e-57 6G51-g nrPDB 217 4e-57 6EOJ-D nrPDB 216 1e-56 6QDV-o nrPDB 214 6e-56 5YZG-W nrPDB 214 6e-56 6HHQ-h nrPDB 213 6e-56 4V6W-Ag nrPDB 211 2e-55 3MKQ-A nrPDB 210 6e-55 5G04-R nrPDB 210 8e-55 3JAP-g nrPDB 209 2e-54 4GGA-A nrPDB 206 9e-54 5WLC-LO nrPDB 205 2e-53 2YNP-A nrPDB 205 2e-53 5LCW-Q nrPDB 204 3e-53 5L9T-R nrPDB 203 1e-52 5I2T-A nrPDB 202 1e-52 3JB9-L nrPDB 199 1e-51 4N14-A nrPDB 199 2e-51 5Z56-q nrPDB 196 1e-50 5WYK-BB nrPDB 192 2e-49 6ID0-T nrPDB 191 3e-49 4LG8-A nrPDB 190 9e-49 5A31-R nrPDB 189 2e-48 5Y88-O nrPDB 188 3e-48 3FM0-A nrPDB 188 4e-48 4BH6-A nrPDB 186 2e-47 5WYJ-BC nrPDB 185 3e-47 4BTS-AR nrPDB 177 4e-45 5FVM-C nrPDB 177 6e-45 3JB9-g nrPDB 176 1e-44 4AEZ-A nrPDB 175 3e-44 6EMK-B nrPDB 174 4e-44 5OQL-X nrPDB 174 4e-44 5OQL-d nrPDB 166 2e-41 6GMH-W nrPDB 165 3e-41 3C9C-A nrPDB 164 7e-41 5Y1U-A nrPDB 163 8e-41 5K1B-B nrPDB 163 1e-40 5OQL-J nrPDB 161 4e-40 5MWJ-A nrPDB 161 5e-40 3CFV-B nrPDB 160 7e-40 2HES-X nrPDB 160 8e-40 6J6H-n nrPDB 159 1e-39 4J0W-A nrPDB 159 1e-39 4YCZ-A nrPDB 157 4e-39 1NR0-A nrPDB 157 9e-39 5WJC-A nrPDB 154 4e-38 5WYJ-BE nrPDB 154 4e-38 5XYI-g nrPDB 154 6e-38 6BX3-A nrPDB 154 7e-38 6CHG-A nrPDB 152 1e-37 4XYI-A nrPDB 151 3e-37 3ODT-A nrPDB 151 5e-37 5WBU-D nrPDB 149 1e-36 5CXC-A nrPDB 149 2e-36 4XFV-A nrPDB 148 4e-36 5K0Y-T nrPDB 144 5e-35 5WLC-LU nrPDB 144 5e-35 4U1E-I nrPDB 141 4e-34 5OQL-L nrPDB 139 1e-33 4L9O-A nrPDB 136 1e-32 6ELZ-p nrPDB 132 2e-31 2AQ5-A nrPDB 129 3e-30 4A11-B nrPDB 127 5e-30 3BG0-A nrPDB 126 1e-29 4E5Z-B nrPDB 123 1e-28 5WLC-LJ nrPDB 122 2e-28 5M89-A nrPDB 122 2e-28 3ACP-A nrPDB 117 9e-27 4G56-B nrPDB 114 5e-26 5WLC-LW nrPDB 109 2e-24 2PM9-A nrPDB 102 2e-22 4OWR-A nrPDB 102 2e-22 2P9P-C nrPDB 101 5e-22 5BJS-A nrPDB 100 1e-21 5A9Q-2 nrPDB 90 1e-18 5A9Q-0 nrPDB 86 2e-17 5WLC-LL nrPDB 65 6e-11 Sequences not found previously or not previously below threshold: 3JRO-A nrPDB 142 3e-34 3JRP-A nrPDB 133 1e-31 4BZK-B nrPDB 129 2e-30 1PI6-A nrPDB 122 2e-28 5N4A-A nrPDB 120 9e-28 5CXB-B nrPDB 112 2e-25 6EM1-m nrPDB 112 2e-25 5FA5-B nrPDB 112 2e-25 6C0F-s nrPDB 112 3e-25 6CB1-s nrPDB 112 3e-25 5WLC-LN nrPDB 107 1e-23 3W15-A nrPDB 101 5e-22 4J0X-A nrPDB 100 6e-22 5WLC-SG nrPDB 100 8e-22 5OV3-A nrPDB 100 1e-21 3F3P-A nrPDB 98 5e-21 4PSX-B nrPDB 97 8e-21 6F1U-h nrPDB 96 2e-20 5A9Q-7 nrPDB 95 4e-20 3EI3-B nrPDB 94 6e-20 6CHG-D nrPDB 93 2e-19 6BX3-B nrPDB 93 2e-19 6E29-D nrPDB 92 4e-19 3I2N-A nrPDB 89 2e-18 3JZG-A nrPDB 86 2e-17 3JB9-S nrPDB 85 4e-17 3DWL-C nrPDB 84 1e-16 5YZG-2 nrPDB 82 3e-16 5AMS-A nrPDB 79 3e-15 5MC6-j nrPDB 75 4e-14 5K19-A nrPDB 74 1e-13 2I3T-A nrPDB 73 2e-13 5LTD-A nrPDB 71 6e-13 5TF2-A nrPDB 70 1e-12 5AJA-A nrPDB 66 2e-11 6IYY-A nrPDB 65 6e-11 3DW8-B nrPDB 63 2e-10 5WLC-LV nrPDB 60 2e-09 5WLC-LS nrPDB 60 2e-09 5K1H-B nrPDB 59 4e-09 2VDU-B nrPDB 58 5e-09 5WLC-LH nrPDB 55 3e-08 6CVZ-A nrPDB 55 5e-08 4AV8-A nrPDB 52 4e-07 6N8P-A nrPDB 51 7e-07 4YHC-A nrPDB 47 1e-05 4NOX-A nrPDB 46 2e-05 4FHN-A nrPDB 46 3e-05 5GRS-A nrPDB 45 6e-05 1Z68-A nrPDB 43 2e-04 5BPW-A nrPDB 43 2e-04 5BPT-A nrPDB 42 3e-04 5WLC-LK nrPDB 42 4e-04 6NAU-A nrPDB 41 6e-04 5CWW-B nrPDB 37 0.010 6FYY-p nrPDB 37 0.012 4MHC-A nrPDB 36 0.026 5LJ5-t nrPDB 35 0.034 1K3I-A nrPDB 35 0.034 1MG2-A nrPDB 35 0.037 2J04-A nrPDB 35 0.040 3WJ9-A nrPDB 35 0.047 4ZB4-A nrPDB 35 0.052 4U1F-A nrPDB 35 0.067 6IGR-A nrPDB 34 0.073 2EEP-A nrPDB 34 0.12 2QT9-A nrPDB 33 0.16 5OLJ-A nrPDB 33 0.22 5HAX-A nrPDB 33 0.26 6GC1-A nrPDB 32 0.34 5SUM-A nrPDB 31 0.62 5L8S-A nrPDB 31 0.84 2GVU-A nrPDB 30 1.3 6AHV-A nrPDB 30 2.1 4BP8-A nrPDB 29 2.5 1D0M-A nrPDB 29 3.0 3MWP-A nrPDB 29 3.3 5JN2-A nrPDB 29 3.4 3MA6-A nrPDB 29 3.4 4Z25-A nrPDB 29 4.4 1RI6-A nrPDB 29 4.4 6FTI-5 nrPDB 28 5.2 3R3L-A nrPDB 28 5.7 1DBI-A nrPDB 28 5.8 >5UZ7-B nrPDB Length = 351 Score = 431 bits (1107), Expect = e-121, Method: Composition-based stats. Identities = 339/339 (100%), Positives = 339/339 (100%) Query: 2 SELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAM 61 SELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAM Sbjct: 13 SELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAM 72 Query: 62 HWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNIC 121 HWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNIC Sbjct: 73 HWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNIC 132 Query: 122 SIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFT 181 SIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFT Sbjct: 133 SIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFT 192 Query: 182 GHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAF 241 GHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAF Sbjct: 193 GHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAF 252 Query: 242 ATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALK 301 ATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALK Sbjct: 253 ATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALK 312 Query: 302 ADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 ADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN Sbjct: 313 ADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 351 >6N9G-C nrPDB Length = 353 Score = 343 bits (880), Expect = 6e-95, Method: Composition-based stats. Identities = 177/341 (51%), Positives = 233/341 (68%), Gaps = 5/341 (1%) Query: 4 LDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHW 63 L L+ EAE LK ++ + R D L Q+ ++ +G+ M+TRRTL+GH K+ M W Sbjct: 12 LASLKSEAESLKGKLEEERAKLHDVELHQVAERVEALGQFVMKTRRTLKGHGNKVLCMDW 71 Query: 64 GTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSI 123 D R +VS+SQDGK+I+WDS+TTNK HA+ + +WVM CAYAPSG +ACGGLDN CS+ Sbjct: 72 CKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSV 131 Query: 124 Y--NLKTREGNVRVSRELAGHTGYLSCCRFLDDN-QIVTSSGDTTCALWDIETGQQTTTF 180 Y E + +A HT YLS C F + + QI+T+SGD TCALWD+E+GQ +F Sbjct: 132 YPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSF 191 Query: 181 TGHTGDVMSLSLAPD--TRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNG 238 GH DV+ L LAP FVSG CD A +WD+R G C Q F HESD+N++ ++P+G Sbjct: 192 HGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDVNSVRYYPSG 251 Query: 239 NAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWD 298 +AFA+GSDDATCRL+DLRAD+E+ YS ++II G +SV FS SGRLL AGY+D+ NVWD Sbjct: 252 DAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWD 311 Query: 299 ALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIW 339 LK R +L GH+NRVS L V+ DG A +GSWD L++W Sbjct: 312 VLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352 Score = 136 bits (342), Expect = 1e-32, Method: Composition-based stats. Identities = 48/219 (21%), Positives = 90/219 (41%), Gaps = 7/219 (3%) Query: 129 REGNVRVSRELAGHTGYLSCCRF-LDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDV 187 + ++ R L GH + C + D +IV+SS D +WD T + T V Sbjct: 49 GQFVMKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWV 108 Query: 188 MSLSLAPDTRLFVSGACDASAKLW------DVREGMCRQTFTGHESDINAICFFPNGNAF 241 M+ + AP G D ++ + +++ H + ++A F + Sbjct: 109 MACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQI 168 Query: 242 ATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALK 301 T S D TC L+D+ + Q L ++ ++ S++G ++G D VWD Sbjct: 169 LTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRS 228 Query: 302 ADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 H++ V+ + G A A+GS D+ ++++ Sbjct: 229 GQCVQAFETHESDVNSVRYYPSGDAFASGSDDATCRLYD 267 >1VYH-C nrPDB Length = 410 Score = 293 bits (750), Expect = 8e-80, Method: Composition-based stats. Identities = 82/358 (22%), Positives = 151/358 (42%), Gaps = 32/358 (8%) Query: 6 QLRQEAEQLKNQIRDARKA-CADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWG 64 +L+++ +L++++ +A++ + L Q + + + R + L GH + + + + Sbjct: 60 RLQKKVMELESKLNEAKEEFTSGGPLGQKRDPKEWIPRPPEK--YALSGHRSPVTRVIFH 117 Query: 65 TDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIY 124 ++VSAS+D + +WD T + + + V ++ SG +A D ++ Sbjct: 118 PVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLW 177 Query: 125 NLKTREGNVRVSRELAGHTGYLSCCRFLDDN-QIVTSSGDTTCALWDIETGQQTTTFTGH 183 + + E R + GH +S + + IV++S D T +W+++TG TFTGH Sbjct: 178 DFQGFE----CIRTMHGHDHNVSSVSIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGH 233 Query: 184 TGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNA--- 240 V + D L S + D + ++W V C+ H + I + P + Sbjct: 234 REWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHRHVVECISWAPESSYSSI 293 Query: 241 -----------------FATGSDDATCRLFDLRADQELMTY-SHDNIICGITSVSFSKSG 282 +GS D T +++D+ LMT HDN + V F G Sbjct: 294 SEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDN---WVRGVLFHSGG 350 Query: 283 RLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 + +L+ DD VWD L H++ V+ L V TGS D +K+W Sbjct: 351 KFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408 >4V7E-Bg nrPDB Length = 380 Score = 291 bits (746), Expect = 2e-79, Method: Composition-based stats. Identities = 160/371 (43%), Positives = 231/371 (62%), Gaps = 32/371 (8%) Query: 1 MSELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTR-----------R 49 M+ + +L+++ + R+ + + +++ + Q RT R Sbjct: 1 MASVAELKEKHAAATASVNSLRERLRQRRQTLLDTDVEKYSKAQGRTAVSFNPTDLVCCR 60 Query: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109 TL+GH K+Y++ W + +VSASQDG+LI+W++ T+ K HAI L WVM CA+AP+G Sbjct: 61 TLQGHSGKVYSLDWTPEKNWIVSASQDGRLIVWNALTSQKTHAIKLHCPWVMECAFAPNG 120 Query: 110 NYVACGGLDNICSIYNLKT---REGNVRVSRELAGHTGYLSCCRFLDDN--QIVTSSGDT 164 VACGGLD+ CSI+NL + R+GN+ VSR L GH GY S C+++ D +++T SGD Sbjct: 121 QSVACGGLDSACSIFNLSSQADRDGNMPVSRVLTGHKGYASSCQYVPDQETRLITGSGDQ 180 Query: 165 TCALWDIETGQQTTTF-----TGHTGDVMSLSLAP-DTRLFVSGACDASAKLWDVR-EGM 217 TC LWD+ TGQ+ + F +GHT DV+SLS+ + +F+SG+CD + +LWD+R Sbjct: 181 TCVLWDVTTGQRISIFGSEFPSGHTADVLSLSINSLNANMFISGSCDTTVRLWDLRITSR 240 Query: 218 CRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYS-----HDNIICG 272 +T+ GHE DIN++ FFP+G F TGSDD TCRLFD+R +L Y+ +DN + Sbjct: 241 AVRTYHGHEGDINSVKFFPDGQRFGTGSDDGTCRLFDMRTGHQLQVYNREPDRNDNELPI 300 Query: 273 ITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVL----AGHDNRVSCLGVTDDGMAVA 328 +TSV+FS SGRLL AGY + +C VWD L A+ L H+ R+SCLG++ DG A+ Sbjct: 301 VTSVAFSISGRLLFAGYSNGDCYVWDTLLAEMVLNLGTLQNSHEGRISCLGLSSDGSALC 360 Query: 329 TGSWDSFLKIW 339 TGSWD LKIW Sbjct: 361 TGSWDKNLKIW 371 Score = 149 bits (375), Expect = 2e-36, Method: Composition-based stats. Identities = 62/281 (22%), Positives = 110/281 (39%), Gaps = 27/281 (9%) Query: 82 WDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAG 141 ++ + S V + + P N++ D ++N T + + + Sbjct: 51 FNPTDLVCCRTLQGHSGKVYSLDWTPEKNWIVSASQDGRLIVWNALTSQK----THAIKL 106 Query: 142 HTGYLSCCRFLDDNQIVTSSG-DTTCALWDIETG-------QQTTTFTGHTGDVMSLSLA 193 H ++ C F + Q V G D+ C+++++ + + TGH G S Sbjct: 107 HCPWVMECAFAPNGQSVACGGLDSACSIFNLSSQADRDGNMPVSRVLTGHKGYASSCQYV 166 Query: 194 PDTRL-FVSGACDASAKLWDVREGMCRQTF-----TGHESDINAICFFP-NGNAFATGSD 246 PD ++G+ D + LWDV G F +GH +D+ ++ N N F +GS Sbjct: 167 PDQETRLITGSGDQTCVLWDVTTGQRISIFGSEFPSGHTADVLSLSINSLNANMFISGSC 226 Query: 247 DATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAG 306 D T RL+DLR + H + I SV F G+ G DD C ++D + Sbjct: 227 DTTVRLWDLRITSRAVRTYHGHEGD-INSVKFFPDGQRFGTGSDDGTCRLFDMRTGHQLQ 285 Query: 307 VLAGHDNR-------VSCLGVTDDGMAVATGSWDSFLKIWN 340 V +R V+ + + G + G + +W+ Sbjct: 286 VYNREPDRNDNELPIVTSVAFSISGRLLFAGYSNGDCYVWD 326 Score = 91.3 bits (225), Expect = 5e-19, Method: Composition-based stats. Identities = 34/154 (22%), Positives = 59/154 (38%), Gaps = 17/154 (11%) Query: 42 RIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAI-------P 94 RI R RT GH I ++ + D + + S DG ++D T +++ Sbjct: 236 RITSRAVRTYHGHEGDINSVKFFPDGQRFGTGSDDGTCRLFDMRTGHQLQVYNREPDRND 295 Query: 95 LRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCC-RFLD 153 V + A++ SG + G + C +++ E + + H G +SC D Sbjct: 296 NELPIVTSVAFSISGRLLFAGYSNGDCYVWDTLLAEMVLNLGTLQNSHEGRISCLGLSSD 355 Query: 154 DNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDV 187 + + T S D +W F+GH V Sbjct: 356 GSALCTGSWDKNLKIW---------AFSGHRKIV 380 Score = 43.9 bits (102), Expect = 9e-05, Method: Composition-based stats. Identities = 11/55 (20%), Positives = 19/55 (34%) Query: 286 LAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 + ++ L GH +V L T + + + S D L +WN Sbjct: 40 YSKAQGRTAVSFNPTDLVCCRTLQGHSGKVYSLDWTPEKNWIVSASQDGRLIVWN 94 >5M25-A nrPDB Length = 434 Score = 285 bits (728), Expect = 2e-77, Method: Composition-based stats. Identities = 78/343 (22%), Positives = 145/343 (42%), Gaps = 12/343 (3%) Query: 3 ELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMH 62 + DQ ++ + N I +A + + +Q + PV + + TL GH + ++ Sbjct: 96 QADQTPEDLDMEDNDIIEAHREQIGGSATQ--SKPTPV-KPNYALKFTLAGHTKAVSSVK 152 Query: 63 WGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICS 122 + + L S+S D + IW +Y I + A++ N + D Sbjct: 153 FSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLK 212 Query: 123 IYNLKTREGNVRVSRELAGHTGYLSCCRFLD-DNQIVTSSGDTTCALWDIETGQQTTTFT 181 I+++ + + + L GH+ Y+ CC F N IV+ S D + +WD++TG+ T Sbjct: 213 IWDVSSG----KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLP 268 Query: 182 GHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTF-TGHESDINAICFFPNGNA 240 H+ V ++ D L VS + D ++WD G C +T ++ + F PNG Sbjct: 269 AHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKY 328 Query: 241 FATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFS-KSGRLLLAGYDDFNCNVWDA 299 + D T +L+D + L TY+ +FS G+ +++G +D +W+ Sbjct: 329 ILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNL 388 Query: 300 LKADRAGVLAGHDNRVSCLGVTDDGMAVATGSW--DSFLKIWN 340 + L GH + V +A+ + D +K+W Sbjct: 389 QTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 431 >5NNZ-B nrPDB Length = 415 Score = 280 bits (716), Expect = 7e-76, Method: Composition-based stats. Identities = 82/292 (28%), Positives = 129/292 (44%), Gaps = 8/292 (2%) Query: 50 TLRGHLAKIYAMHWG-TDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPS 108 TL GH +YA+ + + + S D +W T H ++ ++ ++ P Sbjct: 129 TLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQ 188 Query: 109 GNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRF-LDDNQIVTSSGDTTCA 167 VA G +D +++++ E L GH+ + F ++I+T S D T Sbjct: 189 STLVATGSMDTTAKLWDIQNGEEVY----TLRGHSAEIISLSFNTSGDRIITGSFDHTVV 244 Query: 168 LWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHES 227 +WD +TG++ GH ++ S S D L ++G+ D + KLWD G C T TGH+ Sbjct: 245 VWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDD 304 Query: 228 DINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLA 287 +I CF G AT S D T R+F + + + I+ +SF+ G LL Sbjct: 305 EILDSCFDYTGKLIATASADGTARIFSAATRKCIAKL--EGHEGEISKISFNPQGNHLLT 362 Query: 288 GYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIW 339 G D +WDA VL GH + + G V TGS D+ +IW Sbjct: 363 GSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414 Score = 259 bits (662), Expect = 1e-69, Method: Composition-based stats. Identities = 75/341 (21%), Positives = 149/341 (43%), Gaps = 8/341 (2%) Query: 2 SELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAM 61 +++ L +E ++ + + +R + ++ + + L+ H+ + + Sbjct: 39 TDVSALVEEIQKAEPLLTASRTEQVKLLIQRLQEKLGQNSNHTFYLFKVLKAHILPLTNV 98 Query: 62 HWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYA-PSGNYVACGGLDNI 120 ++ S D +WD+ + +++ + + V A+ P G+ +A G D Sbjct: 99 ALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKT 158 Query: 121 CSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIV-TSSGDTTCALWDIETGQQTTT 179 C +++++T + GHT + C F + +V T S DTT LWDI+ G++ T Sbjct: 159 CKLWSVETG----KCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYT 214 Query: 180 FTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGN 239 GH+ +++SLS ++G+ D + +WD G GH ++I++ F + + Sbjct: 215 LRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCS 274 Query: 240 AFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDA 299 TGS D TC+L+D + + T + I F +G+L+ D ++ A Sbjct: 275 LILTGSMDKTCKLWDATNGKCVATLT--GHDDEILDSCFDYTGKLIATASADGTARIFSA 332 Query: 300 LKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 L GH+ +S + G + TGS D +IW+ Sbjct: 333 ATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWD 373 Score = 218 bits (555), Expect = 3e-57, Method: Composition-based stats. Identities = 70/253 (27%), Positives = 118/253 (46%), Gaps = 7/253 (2%) Query: 46 RTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAY 105 + T RGH A+I + + S L+ + S D +WD +V+ + S+ +++ ++ Sbjct: 168 KCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSF 227 Query: 106 APSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFL-DDNQIVTSSGDT 164 SG+ + G D+ +++ T R L GH +S F D + I+T S D Sbjct: 228 NTSGDRIITGSFDHTVVVWDADTG----RKVNILIGHCAEISSASFNWDCSLILTGSMDK 283 Query: 165 TCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTG 224 TC LWD G+ T TGH +++ +L + + D +A+++ C G Sbjct: 284 TCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEG 343 Query: 225 HESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRL 284 HE +I+ I F P GN TGS D T R++D + Q L + I S +F+ G + Sbjct: 344 HEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVL--EGHTDEIFSCAFNYKGNI 401 Query: 285 LLAGYDDFNCNVW 297 ++ G D C +W Sbjct: 402 VITGSKDNTCRIW 414 Score = 102 bits (254), Expect = 3e-22, Method: Composition-based stats. Identities = 32/131 (24%), Positives = 56/131 (42%), Gaps = 5/131 (3%) Query: 40 VGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSW 99 + TL GH +I + +L+ +AS DG I+ + T + + Sbjct: 288 WDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGE 347 Query: 100 VMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFL-DDNQIV 158 + ++ P GN++ G D I++ +T + + L GHT + C F N ++ Sbjct: 348 ISKISFNPQGNHLLTGSSDKTARIWDAQTGQ----CLQVLEGHTDEIFSCAFNYKGNIVI 403 Query: 159 TSSGDTTCALW 169 T S D TC +W Sbjct: 404 TGSKDNTCRIW 414 >5MZH-A nrPDB Length = 452 Score = 273 bits (699), Expect = 6e-74, Method: Composition-based stats. Identities = 79/340 (23%), Positives = 151/340 (44%), Gaps = 8/340 (2%) Query: 3 ELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMH 62 +++ L + + + I + R+ + ++ + + + LR H+ + Sbjct: 42 DVEVLLSQIIRQEPLISENRRPALRQLIHRLIDKMLEQQHHSFTLFKVLRAHILPLTNCA 101 Query: 63 WGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAY-APSGNYVACGGLDNIC 121 + ++ S D +W+++T +V + + V A+ P G+ + G D C Sbjct: 102 FNKSGDRFITGSYDRTCKVWNTFTGEEVFTLEGHKNVVYAIAFNNPYGDKIVTGSFDKTC 161 Query: 122 SIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIV-TSSGDTTCALWDIETGQQTTTF 180 +++ T + + L GH + C F + I+ T S D T LWD+ETGQ+ T Sbjct: 162 KLWDAYTGQ----LYYTLKGHQTEIVCLSFNPQSTIIATGSMDNTAKLWDVETGQERATL 217 Query: 181 TGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNA 240 GH +++SL L V+G+ D ++LWDVR G C +GH ++++ F G Sbjct: 218 AGHRAEIVSLGFNTGGDLIVTGSFDHDSRLWDVRTGQCVHVLSGHRGEVSSTQFNYAGTL 277 Query: 241 FATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDAL 300 +GS D T RL+D+R+ + L + V+F +G +++ D + ++ L Sbjct: 278 VVSGSIDCTSRLWDVRSGRCLSV--KQGHTDEVLDVAFDAAGTKMVSASADGSARLYHTL 335 Query: 301 KADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 L GH+ +S + G + T S D ++W+ Sbjct: 336 TGVCQHTLVGHEGEISKVAFNPQGTRLITASSDKTCRLWD 375 Score = 271 bits (692), Expect = 3e-73, Method: Composition-based stats. Identities = 82/294 (27%), Positives = 131/294 (44%), Gaps = 10/294 (3%) Query: 50 TLRGHLAKIYAMHWG-TDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPS 108 TL GH +YA+ + +V+ S D +WD+YT + + + ++ ++ P Sbjct: 131 TLEGHKNVVYAIAFNNPYGDKIVTGSFDKTCKLWDAYTGQLYYTLKGHQTEIVCLSFNPQ 190 Query: 109 GNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDN-QIVTSSGDTTCA 167 +A G +DN +++++T + LAGH + F IVT S D Sbjct: 191 STIIATGSMDNTAKLWDVETGQER----ATLAGHRAEIVSLGFNTGGDLIVTGSFDHDSR 246 Query: 168 LWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHES 227 LWD+ TGQ +GH G+V S L VSG+ D +++LWDVR G C GH Sbjct: 247 LWDVRTGQCVHVLSGHRGEVSSTQFNYAGTLVVSGSIDCTSRLWDVRSGRCLSVKQGHTD 306 Query: 228 DINAICFFPNGNAFATGSDDATCRLFDLRADQELMTY-SHDNIICGITSVSFSKSGRLLL 286 ++ + F G + S D + RL+ T H+ I+ V+F+ G L+ Sbjct: 307 EVLDVAFDAAGTKMVSASADGSARLYHTLTGVCQHTLVGHEGE---ISKVAFNPQGTRLI 363 Query: 287 AGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 D C +WD + VL GH + + +G + TGS D+ +IW Sbjct: 364 TASSDKTCRLWDCDTGECLQVLEGHTDEIFSCAFNYEGDFIITGSKDNTCRIWK 417 Score = 225 bits (574), Expect = 2e-59, Method: Composition-based stats. Identities = 69/265 (26%), Positives = 123/265 (46%), Gaps = 7/265 (2%) Query: 40 VGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSW 99 + TL+GH +I + + S ++ + S D +WD T + + + Sbjct: 164 WDAYTGQLYYTLKGHQTEIVCLSFNPQSTIIATGSMDNTAKLWDVETGQERATLAGHRAE 223 Query: 100 VMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFL-DDNQIV 158 +++ + G+ + G D+ +++++T + L+GH G +S +F +V Sbjct: 224 IVSLGFNTGGDLIVTGSFDHDSRLWDVRTGQ----CVHVLSGHRGEVSSTQFNYAGTLVV 279 Query: 159 TSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMC 218 + S D T LWD+ +G+ + GHT +V+ ++ VS + D SA+L+ G+C Sbjct: 280 SGSIDCTSRLWDVRSGRCLSVKQGHTDEVLDVAFDAAGTKMVSASADGSARLYHTLTGVC 339 Query: 219 RQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSF 278 + T GHE +I+ + F P G T S D TCRL+D + L + I S +F Sbjct: 340 QHTLVGHEGEISKVAFNPQGTRLITASSDKTCRLWDCDTGECLQVL--EGHTDEIFSCAF 397 Query: 279 SKSGRLLLAGYDDFNCNVWDALKAD 303 + G ++ G D C +W AL A Sbjct: 398 NYEGDFIITGSKDNTCRIWKALTAS 422 >6QX9-4B nrPDB Length = 522 Score = 256 bits (654), Expect = 1e-68, Method: Composition-based stats. Identities = 80/297 (26%), Positives = 131/297 (44%), Gaps = 16/297 (5%) Query: 53 GHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNY- 111 G I H+ +S++L +A G +W N +H + ++ V + P Sbjct: 229 GDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVS 288 Query: 112 -------VACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIV-TSSGD 163 +A D +++L + E ++ GHT ++ + + + T+ D Sbjct: 289 LDPKDVNLASCAADGSVKLWSLDSDEP----VADIEGHTVRVARVMWHPSGRFLGTTCYD 344 Query: 164 TTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFT 223 + LWD+E ++ GH+ V ++ D L +G DA ++WD+R G C Sbjct: 345 RSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLE 404 Query: 224 GHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSK-SG 282 GH +I I F PNG ATGS D TC+++DLR + + T + +T V F G Sbjct: 405 GHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNL--VTGVKFEPIHG 462 Query: 283 RLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIW 339 LL G D +W LAGH+ +V L ++ DG +AT S+D K+W Sbjct: 463 NFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519 Score = 192 bits (489), Expect = 1e-49, Method: Composition-based stats. Identities = 69/317 (21%), Positives = 128/317 (40%), Gaps = 27/317 (8%) Query: 2 SELDQLRQEAEQLKN---QIRDARKA--CADATLSQITNNIDPVGRIQM------RTRRT 50 S++ +L + L N QI D R C + S++ G ++ T Sbjct: 209 SQMQELHKSLRSLNNFCSQIGDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHT 268 Query: 51 LRGHLAKIYAMHWGTDSRL--------LVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMT 102 LRGH + A+ + S + L S + DG + +W + V I + V Sbjct: 269 LRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVAR 328 Query: 103 CAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIV-TSS 161 + PSG ++ D +++L+ +E GH+ + F D + T Sbjct: 329 VMWHPSGRFLGTTCYDRSWRLWDLEAQEE----ILHQEGHSMGVYDIAFHQDGSLAGTGG 384 Query: 162 GDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQT 221 D +WD+ TG+ GH ++ ++ +P+ +G+ D + K+WD+R+ C T Sbjct: 385 LDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYT 444 Query: 222 FTGHESDINAICFFP-NGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSK 280 H++ + + F P +GN TG+ D T +++ L T + + + S Sbjct: 445 IPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLA--GHEGKVMGLDISS 502 Query: 281 SGRLLLAGYDDFNCNVW 297 G+L+ D +W Sbjct: 503 DGQLIATCSYDRTFKLW 519 Score = 169 bits (429), Expect = 1e-42, Method: Composition-based stats. Identities = 52/209 (24%), Positives = 85/209 (40%), Gaps = 11/209 (5%) Query: 141 GHTGYLSCCRFLDDNQ-IVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRL- 198 G +S C F +++ + T+ C LW + T GH +V ++ P + + Sbjct: 229 GDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVS 288 Query: 199 -------FVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCR 251 S A D S KLW + GH + + + P+G T D + R Sbjct: 289 LDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWR 348 Query: 252 LFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGH 311 L+DL A +E + G+ ++F + G L G D VWD L GH Sbjct: 349 LWDLEAQEE--ILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGH 406 Query: 312 DNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 + + + +G +ATGS D+ K+W+ Sbjct: 407 LKEIYGINFSPNGYHIATGSGDNTCKVWD 435 >2H9P-A nrPDB Length = 329 Score = 254 bits (650), Expect = 3e-68, Method: Composition-based stats. Identities = 72/311 (23%), Positives = 131/311 (42%), Gaps = 10/311 (3%) Query: 35 NNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIP 94 + PV + + TL GH + ++ + + L S+S D + IW +Y I Sbjct: 21 SKPTPV-KPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTIS 79 Query: 95 LRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLD- 153 + A++ N + D I+++ + + + L GH+ Y+ CC F Sbjct: 80 GHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSG----KCLKTLKGHSNYVFCCNFNPQ 135 Query: 154 DNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDV 213 N IV+ S D + +WD++TG+ T H+ V ++ D L VS + D ++WD Sbjct: 136 SNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDT 195 Query: 214 REGMCRQTF-TGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICG 272 G C +T ++ + F PNG + D T +L+D + L TY+ Sbjct: 196 ASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKY 255 Query: 273 ITSVSFS-KSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGS 331 +FS G+ +++G +D +W+ + L GH + V +A+ + Sbjct: 256 CIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAA 315 Query: 332 W--DSFLKIWN 340 D +K+W Sbjct: 316 LENDKTIKLWK 326 >5GAN-H nrPDB Length = 465 Score = 244 bits (624), Expect = 3e-65, Method: Composition-based stats. Identities = 82/294 (27%), Positives = 133/294 (45%), Gaps = 11/294 (3%) Query: 55 LAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKV-HAIPLRSSWVMTCAYAPSGN-YV 112 I A+ TD ++ + S G L + +S T + + + + P N + Sbjct: 175 TKPISAVSLSTDDMVVATGSWAGDLQVLNSQTLQPLTQKLDSHVGKIGAIDWHPDSNNQM 234 Query: 113 ACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIV-TSSGDTTCALWDI 171 D + + EG +R+ +L GH +S ++ + + ++S D T LWD Sbjct: 235 ISCAEDGLIKNFQYSNEEGGLRLLGDLVGHERRISDVKYHPSGKFIGSASHDMTWRLWDA 294 Query: 172 ETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINA 231 T Q+ GH V SLS D L SG D+ + LWD+R G T GH I Sbjct: 295 STHQELLLQEGHDKGVFSLSFQCDGSLVCSGGMDSLSMLWDIRSGSKVMTLAGHSKPIYT 354 Query: 232 ICFFPNGNAFATGSDDATCRLFDLR---ADQELMTYSHDNIICGITSVSFSKS--GRLLL 286 + + PNG ATG D ++D+R Q +H NI +T V FSK G+ L+ Sbjct: 355 VAWSPNGYQVATGGGDGIINVWDIRKRDEGQLNQILAHRNI---VTQVRFSKEDGGKKLV 411 Query: 287 AGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 + D NV+ + + G LAGH +++ L ++++ + +G WD +K+WN Sbjct: 412 SCGYDNLINVYSSDTWLKMGSLAGHTDKIISLDISNNSHFLVSGGWDRSIKLWN 465 Score = 159 bits (402), Expect = 1e-39, Method: Composition-based stats. Identities = 54/262 (20%), Positives = 101/262 (38%), Gaps = 18/262 (6%) Query: 47 TRRTLRGHLAKIYAMHWGTDS-RLLVSASQDGKLIIWDSYTTN----KVHAIPLRSSWVM 101 + L H+ KI A+ W DS ++S ++DG + + + + + Sbjct: 210 LTQKLDSHVGKIGAIDWHPDSNNQMISCAEDGLIKNFQYSNEEGGLRLLGDLVGHERRIS 269 Query: 102 TCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIV-TS 160 Y PSG ++ D +++ T + GH + F D +V + Sbjct: 270 DVKYHPSGKFIGSASHDMTWRLWDASTHQE----LLLQEGHDKGVFSLSFQCDGSLVCSG 325 Query: 161 SGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVR---EGM 217 D+ LWDI +G + T GH+ + +++ +P+ +G D +WD+R EG Sbjct: 326 GMDSLSMLWDIRSGSKVMTLAGHSKPIYTVAWSPNGYQVATGGGDGIINVWDIRKRDEGQ 385 Query: 218 CRQTFTGHESDINAICFFPN--GNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITS 275 Q H + + + F G + D ++ +D L S I S Sbjct: 386 LNQIL-AHRNIVTQVRFSKEDGGKKLVSCGYDNLINVYS--SDTWLKMGSLAGHTDKIIS 442 Query: 276 VSFSKSGRLLLAGYDDFNCNVW 297 + S + L++G D + +W Sbjct: 443 LDISNNSHFLVSGGWDRSIKLW 464 Score = 145 bits (366), Expect = 3e-35, Method: Composition-based stats. Identities = 41/215 (19%), Positives = 86/215 (40%), Gaps = 9/215 (4%) Query: 45 MRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCA 104 +R L GH +I + + + + SAS D +WD+ T ++ V + + Sbjct: 255 LRLLGDLVGHERRISDVKYHPSGKFIGSASHDMTWRLWDASTHQELLLQEGHDKGVFSLS 314 Query: 105 YAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDN-QIVTSSGD 163 + G+ V GG+D++ ++++++ LAGH+ + + + Q+ T GD Sbjct: 315 FQCDGSLVCSGGMDSLSMLWDIRSGSK----VMTLAGHSKPIYTVAWSPNGYQVATGGGD 370 Query: 164 TTCALWDIETGQQ--TTTFTGHTGDVMSLSLA--PDTRLFVSGACDASAKLWDVREGMCR 219 +WDI + H V + + + VS D ++ + Sbjct: 371 GIINVWDIRKRDEGQLNQILAHRNIVTQVRFSKEDGGKKLVSCGYDNLINVYSSDTWLKM 430 Query: 220 QTFTGHESDINAICFFPNGNAFATGSDDATCRLFD 254 + GH I ++ N + +G D + +L++ Sbjct: 431 GSLAGHTDKIISLDISNNSHFLVSGGWDRSIKLWN 465 >5FL8-q nrPDB Length = 515 Score = 238 bits (607), Expect = 3e-63, Method: Composition-based stats. Identities = 72/347 (20%), Positives = 145/347 (41%), Gaps = 24/347 (6%) Query: 9 QEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMR----TRRTLRGHLAKIYAMHWG 64 + + N K ++T QIT P +++ + + GH + I + Sbjct: 93 KTIDITDNLYSSLIKPGYNSTEDQITLLYTPRAVFKVKPVTRSSSAIAGHGSTILCSAFA 152 Query: 65 T-DSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSI 123 S +V+ + D IWD T +H + +WV+ +++P G +A G +DN + Sbjct: 153 PHTSSRMVTGAGDNTARIWDCDTQTPMHTLKGHYNWVLCVSWSPDGEVIATGSMDNTIRL 212 Query: 124 YNLKTREGNVRVSRELAGHTGYLSCCRFLD--------DNQIVTSSGDTTCALWDIETGQ 175 ++ K+ + + L GH+ +++ + ++ +SS D T +WD + Sbjct: 213 WDPKSGQC---LGDALRGHSKWITSLSWEPIHLVKPGSKPRLASSSKDGTIKIWDTVSRV 269 Query: 176 QTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVRE-GMCRQTFTGHESDINAICF 234 T +GHT V + L SG+ D + ++WD+ G C H +N + Sbjct: 270 CQYTMSGHTNSVSCVKWGGQG-LLYSGSHDRTVRVWDINSQGRCINILKSHAHWVNHLSL 328 Query: 235 FPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNC 294 + A G+ D T + + + + IC S +++ DD+ Sbjct: 329 STD-YALRIGAFDHTGKKPSTPEEAQKKALENYEKICKKN----GNSEEMMVTASDDYTM 383 Query: 295 NVWDALKADR-AGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 +W+ LK+ + + GH V+ + + DG + + S+D+ +K+W+ Sbjct: 384 FLWNPLKSTKPIARMTGHQKLVNHVAFSPDGRYIVSASFDNSIKLWD 430 Score = 234 bits (598), Expect = 3e-62, Method: Composition-based stats. Identities = 72/340 (21%), Positives = 134/340 (39%), Gaps = 55/340 (16%) Query: 49 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHA-IPLRSSWVMTCAYAP 107 TL+GH + + W D ++ + S D + +WD + + + S W+ + ++ P Sbjct: 180 HTLKGHYNWVLCVSWSPDGEVIATGSMDNTIRLWDPKSGQCLGDALRGHSKWITSLSWEP 239 Query: 108 -------SGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTS 160 S +A D I++ +R ++GHT +SC ++ + + Sbjct: 240 IHLVKPGSKPRLASSSKDGTIKIWDTVSRVCQY----TMSGHTNSVSCVKWGGQGLLYSG 295 Query: 161 SGDTTCALWDIET-GQQTTTFTGHTGDVMSLSLAPD------------------------ 195 S D T +WDI + G+ H V LSL+ D Sbjct: 296 SHDRTVRVWDINSQGRCINILKSHAHWVNHLSLSTDYALRIGAFDHTGKKPSTPEEAQKK 355 Query: 196 ---------------TRLFVSGACDASAKLWD-VREGMCRQTFTGHESDINAICFFPNGN 239 + V+ + D + LW+ ++ TGH+ +N + F P+G Sbjct: 356 ALENYEKICKKNGNSEEMMVTASDDYTMFLWNPLKSTKPIARMTGHQKLVNHVAFSPDGR 415 Query: 240 AFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDA 299 + S D + +L+D R + + T+ + + V++S RLL++ D VWD Sbjct: 416 YIVSASFDNSIKLWDGRDGKFISTF--RGHVASVYQVAWSSDCRLLVSCSKDTTLKVWDV 473 Query: 300 LKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIW 339 + L GH + V + + DG V +G D +++W Sbjct: 474 RTRKLSVDLPGHKDEVYTVDWSVDGKRVCSGGKDKMVRLW 513 Score = 153 bits (387), Expect = 8e-38, Method: Composition-based stats. Identities = 65/277 (23%), Positives = 113/277 (40%), Gaps = 18/277 (6%) Query: 73 ASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYN---LKTR 129 S D + K + P+++ + Y+ D I +Y + Sbjct: 70 TSDDPVPYTFSCTIQGKKASDPVKTIDITDNLYSSLIKPGYNSTEDQITLLYTPRAVFKV 129 Query: 130 EGNVRVSRELAGHTGYLSCCRFLD--DNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDV 187 + R S +AGH + C F +++VT +GD T +WD +T T GH V Sbjct: 130 KPVTRSSSAIAGHGSTILCSAFAPHTSSRMVTGAGDNTARIWDCDTQTPMHTLKGHYNWV 189 Query: 188 MSLSLAPDTRLFVSGACDASAKLWDVREGMCR-QTFTGHESDINAICFFP-------NGN 239 + +S +PD + +G+ D + +LWD + G C GH I ++ + P + Sbjct: 190 LCVSWSPDGEVIATGSMDNTIRLWDPKSGQCLGDALRGHSKWITSLSWEPIHLVKPGSKP 249 Query: 240 AFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDA 299 A+ S D T +++D + T S ++ V + G LL +G D VWD Sbjct: 250 RLASSSKDGTIKIWDTVSRVCQYTMS--GHTNSVSCVKWGGQG-LLYSGSHDRTVRVWDI 306 Query: 300 LK-ADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSF 335 +L H + V+ L ++ D A+ G++D Sbjct: 307 NSQGRCINILKSHAHWVNHLSLSTD-YALRIGAFDHT 342 Score = 84.0 bits (206), Expect = 9e-17, Method: Composition-based stats. Identities = 29/92 (31%), Positives = 43/92 (46%) Query: 34 TNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAI 93 N+I + T RGH+A +Y + W +D RLLVS S+D L +WD T + Sbjct: 423 DNSIKLWDGRDGKFISTFRGHVASVYQVAWSSDCRLLVSCSKDTTLKVWDVRTRKLSVDL 482 Query: 94 PLRSSWVMTCAYAPSGNYVACGGLDNICSIYN 125 P V T ++ G V GG D + ++ Sbjct: 483 PGHKDEVYTVDWSVDGKRVCSGGKDKMVRLWT 514 >6F3T-A nrPDB Length = 608 Score = 236 bits (602), Expect = 1e-62, Method: Composition-based stats. Identities = 78/286 (27%), Positives = 121/286 (42%), Gaps = 18/286 (6%) Query: 56 AKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACG 115 + A+ DS L+ D + +W + + A + + Sbjct: 279 QGLTAVDVTDDSSLIAGGFADSTVRVWSVTP-----------KKLRSVKQASDLSLIDKE 327 Query: 116 GLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDD-NQIVTSSGDTTCALWDIETG 174 D + I + E + L GH+G + F D N +++SS D T LW ++T Sbjct: 328 SDDVLERIMD----EKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTF 383 Query: 175 QQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICF 234 + GH V +P FVSG D A+LW + F GH +D+N F Sbjct: 384 TCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRF 443 Query: 235 FPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNC 294 PN N ATGS D T RL+D+ + ++ I S++FS +GR L G D Sbjct: 444 HPNSNYVATGSADRTVRLWDVLNGNCVRIFT--GHKGPIHSLTFSPNGRFLATGATDGRV 501 Query: 295 NVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 +WD G L GH + V L + DG +A+GS D+ +++W+ Sbjct: 502 LLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 547 Score = 228 bits (581), Expect = 3e-60, Method: Composition-based stats. Identities = 68/242 (28%), Positives = 110/242 (45%), Gaps = 7/242 (2%) Query: 49 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPS 108 + L GH +Y + D L+S+S+DG + +W T + + V ++P Sbjct: 345 KILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPY 404 Query: 109 GNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDD-NQIVTSSGDTTCA 167 G Y GG D + ++ + + R AGH ++C RF + N + T S D T Sbjct: 405 GYYFVSGGHDRVARLWATD----HYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVR 460 Query: 168 LWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHES 227 LWD+ G FTGH G + SL+ +P+ R +GA D LWD+ G+ GH Sbjct: 461 LWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTD 520 Query: 228 DINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLA 287 + ++ F +G A+GS D T RL+D A + D+ ++ ++ + LL Sbjct: 521 TVCSLRFSRDGEILASGSMDNTVRLWD--AIKAFEDLETDDFTTATGHINLPENSQELLL 578 Query: 288 GY 289 G Sbjct: 579 GT 580 Score = 86.7 bits (213), Expect = 1e-17, Method: Composition-based stats. Identities = 26/164 (15%), Positives = 59/164 (35%), Gaps = 21/164 (12%) Query: 40 VGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSW 99 + R GH I+++ + + R L + + DG++++WD V + + Sbjct: 462 WDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDT 521 Query: 100 VMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVT 159 V + ++ G +A G +DN +++ + L+ + T Sbjct: 522 VCSLRFSRDGEILASGSMDNTVRLWDA-------------------IKAFEDLETDDFTT 562 Query: 160 SSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGA 203 ++G L + T+ + V+ L + +GA Sbjct: 563 ATG--HINLPENSQELLLGTYMTKSTPVVHLHFTRRNLVLAAGA 604 >6MZM-G nrPDB Length = 800 Score = 232 bits (592), Expect = 1e-61, Method: Composition-based stats. Identities = 68/242 (28%), Positives = 110/242 (45%), Gaps = 7/242 (2%) Query: 49 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPS 108 + L GH +Y + D L+S+S+DG + +W T + + V ++P Sbjct: 537 KILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPY 596 Query: 109 GNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDD-NQIVTSSGDTTCA 167 G Y GG D + ++ + + R AGH ++C RF + N + T S D T Sbjct: 597 GYYFVSGGHDRVARLWATD----HYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVR 652 Query: 168 LWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHES 227 LWD+ G FTGH G + SL+ +P+ R +GA D LWD+ G+ GH Sbjct: 653 LWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTD 712 Query: 228 DINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLA 287 + ++ F +G A+GS D T RL+D A + D+ ++ ++ + LL Sbjct: 713 TVCSLRFSRDGEILASGSMDNTVRLWD--AIKAFEDLETDDFTTATGHINLPENSQELLL 770 Query: 288 GY 289 G Sbjct: 771 GT 772 Score = 222 bits (565), Expect = 2e-58, Method: Composition-based stats. Identities = 68/205 (33%), Positives = 100/205 (48%), Gaps = 3/205 (1%) Query: 137 RELAGHTGYLSCCRFLDD-NQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPD 195 + L GH+G + F D N +++SS D T LW ++T + GH V +P Sbjct: 537 KILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPY 596 Query: 196 TRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDL 255 FVSG D A+LW + F GH +D+N F PN N ATGS D T RL+D+ Sbjct: 597 GYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDV 656 Query: 256 RADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRV 315 + ++ I S++FS +GR L G D +WD G L GH + V Sbjct: 657 LNGNCVRIFT--GHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTV 714 Query: 316 SCLGVTDDGMAVATGSWDSFLKIWN 340 L + DG +A+GS D+ +++W+ Sbjct: 715 CSLRFSRDGEILASGSMDNTVRLWD 739 Score = 194 bits (493), Expect = 5e-50, Method: Composition-based stats. Identities = 68/265 (25%), Positives = 106/265 (40%), Gaps = 31/265 (11%) Query: 93 IPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFL 152 + S V +++P NY+ D +++L+T V GH + +F Sbjct: 539 LYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVG----YKGHNYPVWDTQFS 594 Query: 153 DDNQ-IVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLW 211 V+ D LW + Q F GH DV P++ +G+ D + +LW Sbjct: 595 PYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLW 654 Query: 212 DVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIIC 271 DV G C + FTGH+ I+++ F PNG ATG+ D L+D+ LM Sbjct: 655 DVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDI--GHGLMVGELKGHTD 712 Query: 272 GITSVSFSKSGRLLLAGYDDFNCNVWDALKA------DRAGVLAGH-------------- 311 + S+ FS+ G +L +G D +WDA+KA D GH Sbjct: 713 TVCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLETDDFTTATGHINLPENSQELLLGT 772 Query: 312 ----DNRVSCLGVTDDGMAVATGSW 332 V L T + +A G++ Sbjct: 773 YMTKSTPVVHLHFTRRNLVLAAGAY 797 Score = 88.2 bits (217), Expect = 4e-18, Method: Composition-based stats. Identities = 26/164 (15%), Positives = 59/164 (35%), Gaps = 21/164 (12%) Query: 40 VGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSW 99 + R GH I+++ + + R L + + DG++++WD V + + Sbjct: 654 WDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDT 713 Query: 100 VMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVT 159 V + ++ G +A G +DN +++ + L+ + T Sbjct: 714 VCSLRFSRDGEILASGSMDNTVRLWDA-------------------IKAFEDLETDDFTT 754 Query: 160 SSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGA 203 ++G L + T+ + V+ L + +GA Sbjct: 755 ATG--HINLPENSQELLLGTYMTKSTPVVHLHFTRRNLVLAAGA 796 >3DM0-A nrPDB Length = 694 Score = 229 bits (585), Expect = 1e-60, Method: Composition-based stats. Identities = 67/277 (24%), Positives = 115/277 (41%), Gaps = 23/277 (8%) Query: 41 GRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWV 100 + +R L GH + + +D + +S S DG+L +WD + V Sbjct: 416 DKAYGVAQRRLTGHSHFVEDVVLSSDGQFALSGSWDGELRLWDLAAGVSTRRFVGHTKDV 475 Query: 101 MTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDD---NQI 157 ++ A++ + D ++N E +S GH ++SC RF + I Sbjct: 476 LSVAFSLDNRQIVSASRDRTIKLWNTL-GECKYTISEGGEGHRDWVSCVRFSPNTLQPTI 534 Query: 158 VTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGM 217 V++S D T +W++ + +T GHTG V +++++PD L SG D LWD+ EG Sbjct: 535 VSASWDKTVKVWNLSNCKLRSTLAGHTGYVSTVAVSPDGSLCASGGKDGVVLLWDLAEGK 594 Query: 218 CRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICG----- 272 + S I+A+CF PN ++ +++DL + + D Sbjct: 595 KLYSLEA-NSVIHALCFSPNRYWLCAATE-HGIKIWDLESKSIVEDLKVDLKAEAEKADN 652 Query: 273 ------------ITSVSFSKSGRLLLAGYDDFNCNVW 297 TS+++S G L +GY D VW Sbjct: 653 SGPAATKRKVIYCTSLNWSADGSTLFSGYTDGVIRVW 689 Score = 218 bits (556), Expect = 2e-57, Method: Composition-based stats. Identities = 73/327 (22%), Positives = 133/327 (40%), Gaps = 41/327 (12%) Query: 45 MRTRRTLRGHLAKIYAMHWGTDS-RLLVSASQDGKLIIWDSYTTNK-----VHAIPLRSS 98 + + T+R H + A+ D+ ++VSAS+D +I+W +K + S Sbjct: 372 LVLKGTMRAHTDMVTAIATPIDNADIIVSASRDKSIILWKLTKDDKAYGVAQRRLTGHSH 431 Query: 99 WVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQ-I 157 +V + G + G D +++L +R GHT + F DN+ I Sbjct: 432 FVEDVVLSSDGQFALSGSWDGELRLWDLAAGVS----TRRFVGHTKDVLSVAFSLDNRQI 487 Query: 158 VTSSGDTTCALWDIETGQQTTTF----TGHTGDVMSLSLAPDT--RLFVSGACDASAKLW 211 V++S D T LW+ G+ T GH V + +P+T VS + D + K+W Sbjct: 488 VSASRDRTIKLWNTL-GECKYTISEGGEGHRDWVSCVRFSPNTLQPTIVSASWDKTVKVW 546 Query: 212 DVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIIC 271 ++ R T GH ++ + P+G+ A+G D L+DL ++L + +++ Sbjct: 547 NLSNCKLRSTLAGHTGYVSTVAVSPDGSLCASGGKDGVVLLWDLAEGKKLYSLEANSV-- 604 Query: 272 GITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLA----------------GHDNRV 315 I ++ FS + L A + +WD L +V Sbjct: 605 -IHALCFSPNRYWLCAATEHG-IKIWDLESKSIVEDLKVDLKAEAEKADNSGPAATKRKV 662 Query: 316 ---SCLGVTDDGMAVATGSWDSFLKIW 339 + L + DG + +G D +++W Sbjct: 663 IYCTSLNWSADGSTLFSGYTDGVIRVW 689 Score = 168 bits (426), Expect = 2e-42, Method: Composition-based stats. Identities = 55/217 (25%), Positives = 95/217 (43%), Gaps = 12/217 (5%) Query: 135 VSRELAGHTGYLSCCRFLDDNQ--IVTSSGDTTCALW-----DIETGQQTTTFTGHTGDV 187 + + HT ++ DN IV++S D + LW D G TGH+ V Sbjct: 374 LKGTMRAHTDMVTAIATPIDNADIIVSASRDKSIILWKLTKDDKAYGVAQRRLTGHSHFV 433 Query: 188 MSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDD 247 + L+ D + +SG+ D +LWD+ G+ + F GH D+ ++ F + + S D Sbjct: 434 EDVVLSSDGQFALSGSWDGELRLWDLAAGVSTRRFVGHTKDVLSVAFSLDNRQIVSASRD 493 Query: 248 ATCRLFDLRADQELMTYSH--DNIICGITSVSFSKSG--RLLLAGYDDFNCNVWDALKAD 303 T +L++ + T S + ++ V FS + +++ D VW+ Sbjct: 494 RTIKLWNT-LGECKYTISEGGEGHRDWVSCVRFSPNTLQPTIVSASWDKTVKVWNLSNCK 552 Query: 304 RAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 LAGH VS + V+ DG A+G D + +W+ Sbjct: 553 LRSTLAGHTGYVSTVAVSPDGSLCASGGKDGVVLLWD 589 Score = 148 bits (373), Expect = 4e-36, Method: Composition-based stats. Identities = 44/240 (18%), Positives = 89/240 (37%), Gaps = 33/240 (13%) Query: 40 VGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAI----PL 95 + R GH + ++ + D+R +VSAS+D + +W++ + I Sbjct: 457 WDLAAGVSTRRFVGHTKDVLSVAFSLDNRQIVSASRDRTIKLWNTL-GECKYTISEGGEG 515 Query: 96 RSSWVMTCAYAPS--GNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLD 153 WV ++P+ + D ++NL N ++ LAGHTGY+S Sbjct: 516 HRDWVSCVRFSPNTLQPTIVSASWDKTVKVWNLS----NCKLRSTLAGHTGYVSTVAVSP 571 Query: 154 DNQI-VTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWD 212 D + + D LWD+ G++ + + +L +P R ++ A + K+WD Sbjct: 572 DGSLCASGGKDGVVLLWDLAEGKKLYSLEA-NSVIHALCFSP-NRYWLCAATEHGIKIWD 629 Query: 213 VREGMCRQTFTGHESD-------------------INAICFFPNGNAFATGSDDATCRLF 253 + + ++ + +G+ +G D R++ Sbjct: 630 LESKSIVEDLKVDLKAEAEKADNSGPAATKRKVIYCTSLNWSADGSTLFSGYTDGVIRVW 689 Score = 81.7 bits (200), Expect = 4e-16, Method: Composition-based stats. Identities = 27/175 (15%), Positives = 60/175 (34%), Gaps = 28/175 (16%) Query: 37 IDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLR 96 + + R TL GH + + D L S +DG +++WD K++++ Sbjct: 543 VKVWNLSNCKLRSTLAGHTGYVSTVAVSPDGSLCASGGKDGVVLLWDLAEGKKLYSLEAN 602 Query: 97 SSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQ 156 S + ++P+ ++ C ++ I++L+++ + +L Sbjct: 603 -SVIHALCFSPNRYWL-CAATEHGIKIWDLESKSIVEDLKVDLKAEAEKADN-------- 652 Query: 157 IVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLW 211 + T + SL+ + D SG D ++W Sbjct: 653 --SGPAATKRKVI----------------YCTSLNWSADGSTLFSGYTDGVIRVW 689 >6QX9-5O nrPDB Length = 357 Score = 229 bits (584), Expect = 1e-60, Method: Composition-based stats. Identities = 68/296 (22%), Positives = 120/296 (40%), Gaps = 14/296 (4%) Query: 51 LRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSY-TTNKVHAIPLRSSWVMTCAYAPSG 109 L GH ++Y + + L SA D +++W+ Y + + S VM Y G Sbjct: 62 LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDG 121 Query: 110 NYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQ--IVTSSGDTTCA 167 + + D ++++ +T E + L GHT +++ C + T S D T Sbjct: 122 SMLFSASTDKTVAVWDSETGER----VKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVK 177 Query: 168 LWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHES 227 LWDI TF T V++++ + +SG D K+WD+R+ T GH Sbjct: 178 LWDIRKKAAIQTFQN-TYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHAD 236 Query: 228 DINAICFFPNGNAFATGSDDATCRLFDLR----ADQELMTY--SHDNIICGITSVSFSKS 281 + + G+ + + D T R++D+R ++ + + + N + S+S Sbjct: 237 SVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPD 296 Query: 282 GRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLK 337 G + AG D VWD L GH ++ + D + + S D L Sbjct: 297 GSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLY 352 Score = 211 bits (537), Expect = 3e-55, Method: Composition-based stats. Identities = 69/262 (26%), Positives = 120/262 (45%), Gaps = 16/262 (6%) Query: 89 KVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSC 148 + + V C + P+G+ +A G D + ++N+ G+ L GH+G + Sbjct: 58 PIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVY---GDCDNYATLKGHSGAVME 114 Query: 149 CRF-LDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDT-RLFVSGACDA 206 + D + + ++S D T A+WD ETG++ GHT V S A +L +G+ D Sbjct: 115 LHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDG 174 Query: 207 SAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSH 266 + KLWD+R+ QTF + + A+ F + +G D +++DLR ++ +TY+ Sbjct: 175 TVKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNK--LTYTM 231 Query: 267 DNIICGITSVSFSKSGRLLLAGYDDFNCNVWDAL----KADRAGVLAGH----DNRVSCL 318 +T +S S G LL+ D VWD K + G+ + + Sbjct: 232 RGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRC 291 Query: 319 GVTDDGMAVATGSWDSFLKIWN 340 + DG +A GS D F+ +W+ Sbjct: 292 SWSPDGSKIAAGSADRFVYVWD 313 Score = 195 bits (495), Expect = 3e-50, Method: Composition-based stats. Identities = 63/257 (24%), Positives = 111/257 (43%), Gaps = 17/257 (6%) Query: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109 TL+GH + +H+ TD +L SAS D + +WDS T +V + +S+V +C A G Sbjct: 104 TLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRG 163 Query: 110 NYVAC-GGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLD-DNQIVTSSGDTTCA 167 + C G D +++++ + + F D +QI++ D Sbjct: 164 PQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQ-----VLAVTFNDTSDQIISGGIDNDIK 218 Query: 168 LWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREG----MCRQTFT 223 +WD+ + T T GH V LSL+ + +S A D + ++WDVR C + F Sbjct: 219 VWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQ 278 Query: 224 G----HESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFS 279 G E ++ + P+G+ A GS D ++D + + L I V+F Sbjct: 279 GNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLP--GHAGSINEVAFH 336 Query: 280 KSGRLLLAGYDDFNCNV 296 ++++ D + Sbjct: 337 PDEPIIISASSDKRLYM 353 Score = 147 bits (371), Expect = 6e-36, Method: Composition-based stats. Identities = 40/212 (18%), Positives = 87/212 (41%), Gaps = 15/212 (7%) Query: 49 RTLRGHLAKIYAMHWGTDSRLLV-SASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAP 107 + L+GH + + + + LV + S DG + +WD + + V+ + Sbjct: 145 KRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQ-NTYQVLAVTFND 203 Query: 108 SGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCR-FLDDNQIVTSSGDTTC 166 + + + GG+DN +++L+ +++ + GH ++ + + +++++ D T Sbjct: 204 TSDQIISGGIDNDIKVWDLRQN----KLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTV 259 Query: 167 ALWDIETG----QQTTTFTG--H--TGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMC 218 +WD+ + F G H +++ S +PD +G+ D +WD Sbjct: 260 RVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRI 319 Query: 219 RQTFTGHESDINAICFFPNGNAFATGSDDATC 250 GH IN + F P+ + S D Sbjct: 320 LYKLPGHAGSINEVAFHPDEPIIISASSDKRL 351 Score = 103 bits (256), Expect = 1e-22, Method: Composition-based stats. Identities = 31/143 (21%), Positives = 60/143 (41%), Gaps = 13/143 (9%) Query: 33 ITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYT----TN 88 I N+I Q + T+RGH + + ++ L+S + D + +WD Sbjct: 213 IDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKER 272 Query: 89 KVHAIPLR----SSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTG 144 V ++ C+++P G+ +A G D +++ +R R+ +L GH G Sbjct: 273 CVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSR----RILYKLPGHAG 328 Query: 145 YLSCCRFLDDNQ-IVTSSGDTTC 166 ++ F D I+++S D Sbjct: 329 SINEVAFHPDEPIIISASSDKRL 351 Score = 67.8 bits (164), Expect = 6e-12, Method: Composition-based stats. Identities = 16/85 (18%), Positives = 28/85 (32%), Gaps = 1/85 (1%) Query: 257 ADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDAL-KADRAGVLAGHDNRV 315 + + + F +G L + D +W+ D L GH V Sbjct: 53 SSLQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAV 112 Query: 316 SCLGVTDDGMAVATGSWDSFLKIWN 340 L DG + + S D + +W+ Sbjct: 113 MELHYNTDGSMLFSASTDKTVAVWD 137 >5NZU-C nrPDB Length = 905 Score = 228 bits (582), Expect = 2e-60, Method: Composition-based stats. Identities = 62/300 (20%), Positives = 117/300 (39%), Gaps = 11/300 (3%) Query: 42 RIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVM 101 +++ +R L ++ ++ ++++ +G + +W+ T V + V Sbjct: 2 PLRLDIKRKLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVR 61 Query: 102 TCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQ-IVTS 160 + N+V G D ++N T E H+ Y+ C I+TS Sbjct: 62 AAKFVARKNWVVTGADDMQIRVFNYNTLER----VHMFEAHSDYIRCIAVHPTQPFILTS 117 Query: 161 SGDTTCALWDIETG-QQTTTFTGHTGDVMSLSLAP-DTRLFVSGACDASAKLWDVREGMC 218 S D LWD + + F GHT VM + + P D F S + D + K+W + Sbjct: 118 SDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSP 177 Query: 219 RQTFTGHESDINAICFFPNGN--AFATGSDDATCRLFDLRADQELMTYSHDNIICGITSV 276 T GHE +N I ++ G+ +G+DD +++D + + T + ++ Sbjct: 178 NFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTL--EGHAQNVSCA 235 Query: 277 SFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFL 336 SF +++ G +D +W + L RV C+ VA G + + Sbjct: 236 SFHPELPIIITGSEDGTVRIWHSSTYRLESTLNYGMERVWCVASLRGSNNVALGYDEGSI 295 Score = 193 bits (490), Expect = 1e-49, Method: Composition-based stats. Identities = 55/257 (21%), Positives = 105/257 (40%), Gaps = 11/257 (4%) Query: 88 NKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLS 147 + + RS V + P+ ++ + ++N +T+ + + + Sbjct: 6 DIKRKLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQT----LVKTFEVCDLPVR 61 Query: 148 CCRFL-DDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDA 206 +F+ N +VT + D +++ T ++ F H+ + +++ P ++ + D Sbjct: 62 AAKFVARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDM 121 Query: 207 SAKLWDVREG-MCRQTFTGHESDINAICFFP-NGNAFATGSDDATCRLFDLRADQELMTY 264 KLWD + C Q F GH + I P + N FA+ S D T +++ L + T Sbjct: 122 LIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTL 181 Query: 265 SHDNIICGITSVSFSKSG--RLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTD 322 + G+ + + G L++G DD +WD L GH VSC Sbjct: 182 --EGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHP 239 Query: 323 DGMAVATGSWDSFLKIW 339 + + TGS D ++IW Sbjct: 240 ELPIIITGSEDGTVRIW 256 Score = 187 bits (475), Expect = 6e-48, Method: Composition-based stats. Identities = 53/275 (19%), Positives = 108/275 (39%), Gaps = 10/275 (3%) Query: 47 TRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYA 106 +T + A + +V+ + D ++ +++ T +VH S ++ A Sbjct: 49 LVKTFEVCDLPVRAAKFVARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVH 108 Query: 107 PSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLD--DNQIVTSSGDT 164 P+ ++ D + +++ S+ GHT Y+ +NQ ++S D Sbjct: 109 PTQPFILTSSDDMLIKLWDWDK---KWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDR 165 Query: 165 TCALWDIETGQQTTTFTGHTGDVMSLSL--APDTRLFVSGACDASAKLWDVREGMCRQTF 222 T +W + + T GH V + D +SGA D K+WD + C QT Sbjct: 166 TIKVWQLGSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTL 225 Query: 223 TGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSG 282 GH +++ F P TGS+D T R++ + T ++ + + V+ + Sbjct: 226 EGHAQNVSCASFHPELPIIITGSEDGTVRIWHSSTYRLESTLNYG--MERVWCVASLRGS 283 Query: 283 RLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSC 317 + GYD+ + + + + A + + + Sbjct: 284 NNVALGYDEGSI-IVKLGREEPAMSMDANGKIIWA 317 Score = 152 bits (384), Expect = 2e-37, Method: Composition-based stats. Identities = 37/222 (16%), Positives = 74/222 (33%), Gaps = 9/222 (4%) Query: 36 NIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWD-SYTTNKVHAIP 94 I + H I + ++++S D + +WD + Sbjct: 80 QIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKKWSCSQVFE 139 Query: 95 LRSSWVMTCAYAP-SGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLD 153 + +VM P N A LD ++ L + N L GH ++C + Sbjct: 140 GHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNF----TLEGHEKGVNCIDYYS 195 Query: 154 DN---QIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKL 210 +++ + D +WD + T GH +V S P+ + ++G+ D + ++ Sbjct: 196 GGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIIITGSEDGTVRI 255 Query: 211 WDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRL 252 W T + + N A G D+ + + Sbjct: 256 WHSSTYRLESTLNYGMERVWCVASLRGSNNVALGYDEGSIIV 297 Score = 135 bits (340), Expect = 2e-32, Method: Composition-based stats. Identities = 38/210 (18%), Positives = 72/210 (34%), Gaps = 5/210 (2%) Query: 135 VSRELAGHTGYLSCCRFLDDNQIVTSS-GDTTCALWDIETGQQTTTFTGHTGDVMSLSLA 193 + R+L + + + +S + + +W+ ET TF V + Sbjct: 7 IKRKLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFV 66 Query: 194 PDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLF 253 V+GA D ++++ F H I I P T SDD +L+ Sbjct: 67 ARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLW 126 Query: 254 DLRADQELMTYSHDNIICGITSVSFSK-SGRLLLAGYDDFNCNVWDALKADRAGVLAGHD 312 D + + + + + + + D VW + L GH+ Sbjct: 127 DWD-KKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHE 185 Query: 313 NRVSCLGVTDDGM--AVATGSWDSFLKIWN 340 V+C+ G + +G+ D +KIW+ Sbjct: 186 KGVNCIDYYSGGDKPYLISGADDRLVKIWD 215 >6HQA-B nrPDB Length = 722 Score = 227 bits (579), Expect = 4e-60, Method: Composition-based stats. Identities = 60/271 (22%), Positives = 117/271 (43%), Gaps = 21/271 (7%) Query: 89 KVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIY----------------NLKTREG- 131 ++ ++ + + VA G D+ ++ N + +G Sbjct: 382 CMYTFHNTNNDLTCLKFNDDSTMVASGFQDSFIKLWSIDGSPLRSLLKNDPYNQQNNDGV 441 Query: 132 NVRVSRELAGHTGYLSCCRFLDDNQ-IVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSL 190 V+ SR L GH+G + F DN+ +++ S D T LW ++T ++ GH+ V + Sbjct: 442 AVKGSRRLVGHSGAVYGVDFSPDNRYLISCSEDKTVRLWSLDTYTCLVSYKGHSSSVWDV 501 Query: 191 SLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATC 250 +P F + + D +A+LW + F GH +D++ + F PN TGS D T Sbjct: 502 KFSPMGHYFATASHDQTARLWSCDHIYPLRIFAGHLNDVDCVEFHPNSTYLFTGSSDKTA 561 Query: 251 RLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAG 310 R++D+ + + + I ++ S GR L + +D +WD R + G Sbjct: 562 RMWDIARGECVRVF--MGHSGAINCLAVSPDGRWLASAGEDSVVCLWDISTGRRIKAMRG 619 Query: 311 H-DNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 H + + L + +G + + D+ +++W+ Sbjct: 620 HGRSSIYSLAFSREGTVLVSTGADNSVRVWD 650 Score = 213 bits (543), Expect = 7e-56, Method: Composition-based stats. Identities = 58/221 (26%), Positives = 102/221 (46%), Gaps = 6/221 (2%) Query: 41 GRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWV 100 + ++ R L GH +Y + + D+R L+S S+D + +W T + + SS V Sbjct: 439 DGVAVKGSRRLVGHSGAVYGVDFSPDNRYLISCSEDKTVRLWSLDTYTCLVSYKGHSSSV 498 Query: 101 MTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIV-T 159 ++P G+Y A D +++ ++ R AGH + C F ++ + T Sbjct: 499 WDVKFSPMGHYFATASHDQTARLWSCD----HIYPLRIFAGHLNDVDCVEFHPNSTYLFT 554 Query: 160 SSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCR 219 S D T +WDI G+ F GH+G + L+++PD R S D+ LWD+ G Sbjct: 555 GSSDKTARMWDIARGECVRVFMGHSGAINCLAVSPDGRWLASAGEDSVVCLWDISTGRRI 614 Query: 220 QTFTGH-ESDINAICFFPNGNAFATGSDDATCRLFDLRADQ 259 + GH S I ++ F G + D + R++D++ + Sbjct: 615 KAMRGHGRSSIYSLAFSREGTVLVSTGADNSVRVWDVKKNT 655 Score = 199 bits (505), Expect = 2e-51, Method: Composition-based stats. Identities = 59/278 (21%), Positives = 107/278 (38%), Gaps = 27/278 (9%) Query: 49 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTT--------------------- 87 T + + + DS ++ S QD + +W + Sbjct: 384 YTFHNTNNDLTCLKFNDDSTMVASGFQDSFIKLWSIDGSPLRSLLKNDPYNQQNNDGVAV 443 Query: 88 NKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLS 147 + S V ++P Y+ D +++L T V GH+ + Sbjct: 444 KGSRRLVGHSGAVYGVDFSPDNRYLISCSEDKTVRLWSLDTYTCLV----SYKGHSSSVW 499 Query: 148 CCRFLD-DNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDA 206 +F + T+S D T LW + F GH DV + P++ +G+ D Sbjct: 500 DVKFSPMGHYFATASHDQTARLWSCDHIYPLRIFAGHLNDVDCVEFHPNSTYLFTGSSDK 559 Query: 207 SAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSH 266 +A++WD+ G C + F GH IN + P+G A+ +D+ L+D+ + + Sbjct: 560 TARMWDIARGECVRVFMGHSGAINCLAVSPDGRWLASAGEDSVVCLWDISTGRRIKAMR- 618 Query: 267 DNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADR 304 + I S++FS+ G +L++ D + VWD K Sbjct: 619 GHGRSSIYSLAFSREGTVLVSTGADNSVRVWDVKKNTN 656 >6Q8F-A nrPDB Length = 514 Score = 225 bits (573), Expect = 2e-59, Method: Composition-based stats. Identities = 59/310 (19%), Positives = 119/310 (38%), Gaps = 19/310 (6%) Query: 47 TRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIP--------LRSS 98 +R G + + + D + LV+ S DG + +W+ T + + Sbjct: 207 SRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDD 266 Query: 99 WVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFL-DDNQI 157 V+ ++ +A G D ++ +++ + R R H+ ++C F D +QI Sbjct: 267 AVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFER---AHSKGVTCLSFSKDSSQI 323 Query: 158 VTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGM 217 +++S D T + +++G+ F GH+ V + D +S + D + K+W+++ Sbjct: 324 LSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTE 383 Query: 218 CRQTFT------GHESDINAICFFP-NGNAFATGSDDATCRLFDLRADQELMTYSHDNII 270 C TF G + +N++ P N F + T + +++ S Sbjct: 384 CSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKREG 443 Query: 271 CGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATG 330 + S G + +DF + + L H+ V + +AT Sbjct: 444 GDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATY 503 Query: 331 SWDSFLKIWN 340 S D LK+W Sbjct: 504 SEDGLLKLWK 513 Score = 100 bits (249), Expect = 1e-21, Method: Composition-based stats. Identities = 39/174 (22%), Positives = 64/174 (36%), Gaps = 10/174 (5%) Query: 46 RTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSS------W 99 +T + RGH + + + D ++SAS DG + IW+ TT + S Sbjct: 341 KTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDIT 400 Query: 100 VMTCAYAPSG-NYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIV 158 V + P + N I N++ + S + G G CC + + Sbjct: 401 VNSVILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKREG--GDFVCCALSPRGEWI 458 Query: 159 TS-SGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLW 211 D + TG+ T T H DV+ ++ P L + + D KLW Sbjct: 459 YCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLW 512 Score = 67.0 bits (162), Expect = 1e-11, Method: Composition-based stats. Identities = 20/91 (21%), Positives = 33/91 (36%), Gaps = 8/91 (8%) Query: 258 DQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGH------ 311 +L + + FS G+ L+ G D VW+ L Sbjct: 203 PTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFM 262 Query: 312 --DNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 D+ V C+ + D +ATG+ D +K+W Sbjct: 263 MMDDAVLCMCFSRDTEMLATGAQDGKIKVWK 293 Score = 39.7 bits (91), Expect = 0.002, Method: Composition-based stats. Identities = 10/44 (22%), Positives = 18/44 (40%) Query: 39 PVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIW 82 + + RTL H + + L+ + S+DG L +W Sbjct: 469 CFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLW 512 >5OPT-p nrPDB Length = 318 Score = 221 bits (562), Expect = 4e-58, Method: Composition-based stats. Identities = 71/262 (27%), Positives = 114/262 (43%), Gaps = 13/262 (4%) Query: 48 RRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAP 107 R L GH A + + + VSAS D L +W+ T H + V++ ++P Sbjct: 60 ERRLEGHSAFVSDVALSNNGDFAVSASWDHSLRLWNLQTGVCQHKFLGHTKDVLSVTFSP 119 Query: 108 SGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDD---NQIVTSSGDT 164 + GG DN ++N+K G + HT ++SC RF IV+ D Sbjct: 120 DNRQIVSGGRDNALRVWNVK---GECLHTLGRGAHTDWVSCVRFSPSLETPLIVSGGWDN 176 Query: 165 TCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTG 224 +WDI +G+ T GHT + S++++PD L S D A+LWD+ +G Sbjct: 177 LVKVWDIASGRLLTDLKGHTNYITSVTVSPDGSLCASSDKDGVARLWDLTKGEALSEMAA 236 Query: 225 HESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHD-----NIICGITSVSFS 279 + IN ICF PN + + + R+FDL ++ + + S+++S Sbjct: 237 -GAPINQICFSPN-RYWMCAATEKGIRIFDLENKDVIVELAPEAQQKSKKTPECMSIAWS 294 Query: 280 KSGRLLLAGYDDFNCNVWDALK 301 G L +GY D VW + Sbjct: 295 ADGNTLYSGYTDNVIRVWSVSE 316 Score = 194 bits (492), Expect = 6e-50, Method: Composition-based stats. Identities = 69/314 (21%), Positives = 124/314 (39%), Gaps = 33/314 (10%) Query: 51 LRGHLAKIYAMH---WGTDSRLLVSASQDGKLIIW---------DSYTTNKVHAIPLRSS 98 L+GH + A+ VS S+D LI W + + S+ Sbjct: 9 LKGHRGWVTALACPQITETYIKAVSTSRDNTLIAWGSNMDRNSEECEYGFPERRLEGHSA 68 Query: 99 WVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQ-I 157 +V A + +G++ D+ ++NL+T + GHT + F DN+ I Sbjct: 69 FVSDVALSNNGDFAVSASWDHSLRLWNLQTGVCQHKFL----GHTKDVLSVTFSPDNRQI 124 Query: 158 VTSSGDTTCALWDIETGQQTTTF--TGHTGDVMSLSLAP--DTRLFVSGACDASAKLWDV 213 V+ D +W+++ G+ T HT V + +P +T L VSG D K+WD+ Sbjct: 125 VSGGRDNALRVWNVK-GECLHTLGRGAHTDWVSCVRFSPSLETPLIVSGGWDNLVKVWDI 183 Query: 214 REGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGI 273 G GH + I ++ P+G+ A+ D RL+DL + L + I Sbjct: 184 ASGRLLTDLKGHTNYITSVTVSPDGSLCASSDKDGVARLWDLTKGEALSEMAA---GAPI 240 Query: 274 TSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVL-------AGHDNRVSCLGVTDDGMA 326 + FS + + A + ++D D L + + + DG Sbjct: 241 NQICFSPNRYWMCAATEKG-IRIFDLENKDVIVELAPEAQQKSKKTPECMSIAWSADGNT 299 Query: 327 VATGSWDSFLKIWN 340 + +G D+ +++W+ Sbjct: 300 LYSGYTDNVIRVWS 313 Score = 166 bits (421), Expect = 1e-41, Method: Composition-based stats. Identities = 54/220 (24%), Positives = 98/220 (44%), Gaps = 16/220 (7%) Query: 136 SRELAGHTGYLSCCRFLDDN----QIVTSSGDTTCALW---------DIETGQQTTTFTG 182 +L GH G+++ + V++S D T W + E G G Sbjct: 6 EGQLKGHRGWVTALACPQITETYIKAVSTSRDNTLIAWGSNMDRNSEECEYGFPERRLEG 65 Query: 183 HTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFA 242 H+ V ++L+ + VS + D S +LW+++ G+C+ F GH D+ ++ F P+ Sbjct: 66 HSAFVSDVALSNNGDFAVSASWDHSLRLWNLQTGVCQHKFLGHTKDVLSVTFSPDNRQIV 125 Query: 243 TGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKS--GRLLLAGYDDFNCNVWDAL 300 +G D R+++++ + L T ++ V FS S L+++G D VWD Sbjct: 126 SGGRDNALRVWNVK-GECLHTLGRGAHTDWVSCVRFSPSLETPLIVSGGWDNLVKVWDIA 184 Query: 301 KADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 L GH N ++ + V+ DG A+ D ++W+ Sbjct: 185 SGRLLTDLKGHTNYITSVTVSPDGSLCASSDKDGVARLWD 224 Score = 64.7 bits (156), Expect = 5e-11, Method: Composition-based stats. Identities = 24/143 (16%), Positives = 54/143 (37%), Gaps = 6/143 (4%) Query: 34 TNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAI 93 N + R L+GH I ++ D L S+ +DG +WD + + Sbjct: 175 DNLVKVWDIASGRLLTDLKGHTNYITSVTVSPDGSLCASSDKDGVARLWDLTKGEALSEM 234 Query: 94 PLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTG----YLSCC 149 + + ++P+ ++ C + I++L+ ++ V ++ E + +S Sbjct: 235 AA-GAPINQICFSPNRYWM-CAATEKGIRIFDLENKDVIVELAPEAQQKSKKTPECMSIA 292 Query: 150 RFLDDNQIVTSSGDTTCALWDIE 172 D N + + D +W + Sbjct: 293 WSADGNTLYSGYTDNVIRVWSVS 315 >4V8M-A7 nrPDB Length = 318 Score = 219 bits (558), Expect = 1e-57, Method: Composition-based stats. Identities = 72/261 (27%), Positives = 117/261 (44%), Gaps = 13/261 (4%) Query: 49 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPS 108 R L GH A + + + VSAS D L +W+ + + V++ A++P Sbjct: 61 RRLEGHSAFVSDVALSNNGNFAVSASWDHSLRLWNLQNGQCQYKFLGHTKDVLSVAFSPD 120 Query: 109 GNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDD---NQIVTSSGDTT 165 + GG DN ++N+K G + HT ++SC RF IV+ D Sbjct: 121 NRQIVSGGRDNALRVWNVK---GECMHTLSRGAHTDWVSCVRFSPSLDAPVIVSGGWDNL 177 Query: 166 CALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGH 225 +WD+ TG+ T GHT V S++++PD L S D A+LWD+ +G Sbjct: 178 VKVWDLATGRLVTDLKGHTNYVTSVTVSPDGSLCASSDKDGVARLWDLTKGEALSEMAA- 236 Query: 226 ESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDN-----IICGITSVSFSK 280 + IN ICF PN + + + R+FDL ++ + ++ I+ S+++S Sbjct: 237 GAPINQICFSPN-RYWMCAATEKGIRIFDLENKDIIVELAPEHQGSKKIVPECVSIAWSA 295 Query: 281 SGRLLLAGYDDFNCNVWDALK 301 G L +GY D VW + Sbjct: 296 DGSTLYSGYTDNVIRVWGVSE 316 Score = 194 bits (493), Expect = 5e-50, Method: Composition-based stats. Identities = 68/313 (21%), Positives = 128/313 (40%), Gaps = 33/313 (10%) Query: 51 LRGHLAKIYAMHWGTDSR---LLVSASQDGKLIIW----DSYTTNKVHAIP-----LRSS 98 L GH + ++ +VS S+D L+ W D +++ + +P S+ Sbjct: 9 LTGHRGWVTSLACPQTPETATKVVSTSRDKTLLSWGPNPDRHSSECSYGLPDRRLEGHSA 68 Query: 99 WVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQ-I 157 +V A + +GN+ D+ ++NL+ + + GHT + F DN+ I Sbjct: 69 FVSDVALSNNGNFAVSASWDHSLRLWNLQNGQCQYKFL----GHTKDVLSVAFSPDNRQI 124 Query: 158 VTSSGDTTCALWDIETGQQTTTFT--GHTGDVMSLSLAP--DTRLFVSGACDASAKLWDV 213 V+ D +W+++ G+ T + HT V + +P D + VSG D K+WD+ Sbjct: 125 VSGGRDNALRVWNVK-GECMHTLSRGAHTDWVSCVRFSPSLDAPVIVSGGWDNLVKVWDL 183 Query: 214 REGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGI 273 G GH + + ++ P+G+ A+ D RL+DL + L + I Sbjct: 184 ATGRLVTDLKGHTNYVTSVTVSPDGSLCASSDKDGVARLWDLTKGEALSEMAA---GAPI 240 Query: 274 TSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVL-AGHDNRV------SCLGVTDDGMA 326 + FS + + A + ++D D L H + + DG Sbjct: 241 NQICFSPNRYWMCAATEKG-IRIFDLENKDIIVELAPEHQGSKKIVPECVSIAWSADGST 299 Query: 327 VATGSWDSFLKIW 339 + +G D+ +++W Sbjct: 300 LYSGYTDNVIRVW 312 Score = 172 bits (436), Expect = 2e-43, Method: Composition-based stats. Identities = 53/223 (23%), Positives = 98/223 (43%), Gaps = 16/223 (7%) Query: 133 VRVSRELAGHTGYLSCCRFLDDN----QIVTSSGDTTCALW---------DIETGQQTTT 179 V +L GH G+++ ++V++S D T W + G Sbjct: 3 VAYEGQLTGHRGWVTSLACPQTPETATKVVSTSRDKTLLSWGPNPDRHSSECSYGLPDRR 62 Query: 180 FTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGN 239 GH+ V ++L+ + VS + D S +LW+++ G C+ F GH D+ ++ F P+ Sbjct: 63 LEGHSAFVSDVALSNNGNFAVSASWDHSLRLWNLQNGQCQYKFLGHTKDVLSVAFSPDNR 122 Query: 240 AFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSK--SGRLLLAGYDDFNCNVW 297 +G D R+++++ + + T S ++ V FS ++++G D VW Sbjct: 123 QIVSGGRDNALRVWNVK-GECMHTLSRGAHTDWVSCVRFSPSLDAPVIVSGGWDNLVKVW 181 Query: 298 DALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 D L GH N V+ + V+ DG A+ D ++W+ Sbjct: 182 DLATGRLVTDLKGHTNYVTSVTVSPDGSLCASSDKDGVARLWD 224 Score = 136 bits (343), Expect = 1e-32, Method: Composition-based stats. Identities = 43/224 (19%), Positives = 92/224 (41%), Gaps = 19/224 (8%) Query: 48 RRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIP--LRSSWVMTCAY 105 + GH + ++ + D+R +VS +D L +W+ +H + + WV + Sbjct: 102 QYKFLGHTKDVLSVAFSPDNRQIVSGGRDNALRVWNVK-GECMHTLSRGAHTDWVSCVRF 160 Query: 106 AP--SGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSG- 162 +P + GG DN+ +++L T R+ +L GHT Y++ D + SS Sbjct: 161 SPSLDAPVIVSGGWDNLVKVWDLATG----RLVTDLKGHTNYVTSVTVSPDGSLCASSDK 216 Query: 163 DTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTF 222 D LWD+ G+ + + + +P R ++ A + +++D+ Sbjct: 217 DGVARLWDLTKGEALSEMAA-GAPINQICFSP-NRYWMCAATEKGIRIFDLENKDIIVEL 274 Query: 223 TG-HES------DINAICFFPNGNAFATGSDDATCRLFDLRADQ 259 H+ + +I + +G+ +G D R++ + + Sbjct: 275 APEHQGSKKIVPECVSIAWSADGSTLYSGYTDNVIRVWGVSENA 318 Score = 69.3 bits (168), Expect = 2e-12, Method: Composition-based stats. Identities = 25/159 (15%), Positives = 57/159 (35%), Gaps = 10/159 (6%) Query: 20 DARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKL 79 DA + N + R L+GH + ++ D L S+ +DG Sbjct: 165 DAPVIVSGGW----DNLVKVWDLATGRLVTDLKGHTNYVTSVTVSPDGSLCASSDKDGVA 220 Query: 80 IIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSREL 139 +WD + + + + ++P+ ++ C + I++L+ ++ V ++ E Sbjct: 221 RLWDLTKGEALSEMAA-GAPINQICFSPNRYWM-CAATEKGIRIFDLENKDIIVELAPEH 278 Query: 140 AGHTG----YLSCCRFLDDNQIVTSSGDTTCALWDIETG 174 G +S D + + + D +W + Sbjct: 279 QGSKKIVPECVSIAWSADGSTLYSGYTDNVIRVWGVSEN 317 >6G51-g nrPDB Length = 317 Score = 217 bits (553), Expect = 4e-57, Method: Composition-based stats. Identities = 72/267 (26%), Positives = 120/267 (44%), Gaps = 15/267 (5%) Query: 48 RRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAP 107 +R LRGH + + +D + +S S DG L +WD T + V++ A++ Sbjct: 56 QRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSS 115 Query: 108 SGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQ---IVTSSGDT 164 + G D ++N G + + + H+ ++SC RF ++ IV+ D Sbjct: 116 DNRQIVSGSRDKTIKLWNT---LGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDK 172 Query: 165 TCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTG 224 +W++ + T GHTG + +++++PD L SG D A LWD+ EG T G Sbjct: 173 LVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG 232 Query: 225 HESDINAICFFPNGNAFATGSDDATCRLFDLRA-------DQELMTYSHDNIICGITSVS 277 INA+CF PN + + +++DL QE+++ S TS++ Sbjct: 233 -GDIINALCFSPNRYWLCAATG-PSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLA 290 Query: 278 FSKSGRLLLAGYDDFNCNVWDALKADR 304 +S G+ L AGY D VW R Sbjct: 291 WSADGQTLFAGYTDNLVRVWQVTIGTR 317 Score = 202 bits (513), Expect = 2e-52, Method: Composition-based stats. Identities = 72/316 (22%), Positives = 127/316 (40%), Gaps = 27/316 (8%) Query: 44 QMRTRRTLRGHLAKIYAMHWGTD-SRLLVSASQDGKLIIW-----DSYTTNKVHAIPLRS 97 QM R TL+GH + + +++SAS+D +I+W ++ A+ S Sbjct: 4 QMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHS 63 Query: 98 SWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQ- 156 +V + G + G D +++L T +R GHT + F DN+ Sbjct: 64 HFVSDVVISSDGQFALSGSWDGTLRLWDLTTGT----TTRRFVGHTKDVLSVAFSSDNRQ 119 Query: 157 IVTSSGDTTCALWDIET-GQQTTTFTGHTGDVMSLSLAPDTR--LFVSGACDASAKLWDV 213 IV+ S D T LW+ + T H+ V + +P++ + VS D K+W++ Sbjct: 120 IVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNL 179 Query: 214 REGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGI 273 + GH +N + P+G+ A+G D L+DL + L T +I I Sbjct: 180 ANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDI---I 236 Query: 274 TSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVL---------AGHDNRVSCLGVTDDG 324 ++ FS + L A + +WD L + + L + DG Sbjct: 237 NALCFSPNRYWLCAATG-PSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADG 295 Query: 325 MAVATGSWDSFLKIWN 340 + G D+ +++W Sbjct: 296 QTLFAGYTDNLVRVWQ 311 Score = 159 bits (401), Expect = 2e-39, Method: Composition-based stats. Identities = 47/220 (21%), Positives = 94/220 (42%), Gaps = 10/220 (4%) Query: 130 EGNVRVSRELAGHTGYLSCCRFLDD--NQIVTSSGDTTCALW-----DIETGQQTTTFTG 182 + + L GH G+++ + I+++S D T +W + G G Sbjct: 2 TEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRG 61 Query: 183 HTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFA 242 H+ V + ++ D + +SG+ D + +LWD+ G + F GH D+ ++ F + Sbjct: 62 HSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIV 121 Query: 243 TGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSG--RLLLAGYDDFNCNVWDAL 300 +GS D T +L++ T ++ ++ V FS + ++++ D VW+ Sbjct: 122 SGSRDKTIKLWNT-LGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLA 180 Query: 301 KADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 GH ++ + V+ DG A+G D +W+ Sbjct: 181 NCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWD 220 Score = 63.9 bits (154), Expect = 9e-11, Method: Composition-based stats. Identities = 19/144 (13%), Positives = 51/144 (35%), Gaps = 8/144 (5%) Query: 37 IDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLR 96 + + + GH + + D L S +DG+ ++WD ++ + Sbjct: 174 VKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG- 232 Query: 97 SSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGY-----LSCCRF 151 + ++P+ ++ C I++L+ + + +E+ + + + Sbjct: 233 GDIINALCFSPNRYWL-CAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAW 291 Query: 152 LDDNQIVTSSG-DTTCALWDIETG 174 D Q + + D +W + G Sbjct: 292 SADGQTLFAGYTDNLVRVWQVTIG 315 >6EOJ-D nrPDB Length = 470 Score = 216 bits (551), Expect = 1e-56, Method: Composition-based stats. Identities = 78/336 (23%), Positives = 132/336 (39%), Gaps = 20/336 (5%) Query: 11 AEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLL 70 E + D A ++ N + + I A+ W + R L Sbjct: 55 VEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVK------HVIPAIQWTPEGRRL 108 Query: 71 VSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTRE 130 V A+ G+ +W++ + + S V T Y+ +++ G D + I+ + Sbjct: 109 VVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIW-----Q 163 Query: 131 GNVRVSREL-AGHTGYLSCCRF-LDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVM 188 N + +E+ A HT + F +D++ VT S D +W+ G+Q +GH DV Sbjct: 164 PNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVK 223 Query: 189 SLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPN-GNAFATGSDD 247 S P+ L S + D KLWD R G C + + + F P GN S D Sbjct: 224 SCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKD 283 Query: 248 ATCRLFDLRAD-QELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAG 306 +CR+FD+R +ELM + + ++S L D + +D L+ Sbjct: 284 KSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLAC--YDGSLKHFDLLQNLNEP 341 Query: 307 VLA---GHDNRVSCLGVTDDGMAVATGSWDSFLKIW 339 +L HD ++ L G AT + D ++ W Sbjct: 342 ILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFW 377 Score = 77.4 bits (189), Expect = 8e-15, Method: Composition-based stats. Identities = 21/115 (18%), Positives = 42/115 (36%), Gaps = 2/115 (1%) Query: 226 ESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLL 285 + I AI + P G + L++ + +T++ +S + Sbjct: 93 KHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFT--FETLMQAHDSAVTTMKYSHDSDWM 150 Query: 286 LAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 ++G D +W + + A H + + + + T S D+ LKIWN Sbjct: 151 ISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWN 205 Score = 60.9 bits (146), Expect = 7e-10, Method: Composition-based stats. Identities = 18/96 (18%), Positives = 38/96 (39%), Gaps = 5/96 (5%) Query: 245 SDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADR 304 D L + S + + I ++ ++ GR L+ ++W+A Sbjct: 73 GRDRVINL-----PSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTF 127 Query: 305 AGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 ++ HD+ V+ + + D + +G D +KIW Sbjct: 128 ETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQ 163 Score = 45.8 bits (107), Expect = 3e-05, Method: Composition-based stats. Identities = 13/69 (18%), Positives = 24/69 (34%), Gaps = 4/69 (5%) Query: 61 MHWGTDSRLLVS-ASQDGKLIIWDSYTT--NKVHAIP-LRSSWVMTCAYAPSGNYVACGG 116 + W + + + A DG L +D + IP + + +Y P G+ A Sbjct: 310 LEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAA 369 Query: 117 LDNICSIYN 125 D + Sbjct: 370 KDRTIRFWT 378 >6QDV-o nrPDB Length = 513 Score = 214 bits (544), Expect = 6e-56, Method: Composition-based stats. Identities = 62/310 (20%), Positives = 108/310 (34%), Gaps = 18/310 (5%) Query: 43 IQMRTRRTLRGHLAKIYAMH-WGTDSRLLVSASQDGKLIIWDSYTTN-KVHAIPLRSSWV 100 + + GH + A+ + LL+S S D K+ +W+ Y + S V Sbjct: 210 LPKKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAV 269 Query: 101 MTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDD----NQ 156 + +G D +++ +T + R + C +F D N Sbjct: 270 RDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNR-----KVPYCVKFNPDEDKQNL 324 Query: 157 IVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREG 216 V D WDI +G+ + H G V ++ + R FVS + D S ++W+ Sbjct: 325 FVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIP 384 Query: 217 -MCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFD----LRADQELMTYSHDNIIC 271 + + A+ PNG A S D +F R +++ + H Sbjct: 385 VDFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGY 444 Query: 272 GITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTD-DGMAVATG 330 V FS +++G + N+WD HD + V T Sbjct: 445 AC-QVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETSKVITC 503 Query: 331 SWDSFLKIWN 340 WD +K+W+ Sbjct: 504 GWDGLIKLWD 513 Score = 64.3 bits (155), Expect = 7e-11, Method: Composition-based stats. Identities = 17/87 (19%), Positives = 34/87 (39%), Gaps = 3/87 (3%) Query: 42 RIQMRTRRTLRGH--LAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSW 99 R ++ ++ +GH + + D ++S +GKL IWD TT Sbjct: 427 RFRLNKKKIFKGHMVAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKV 486 Query: 100 VMTCAYAPS-GNYVACGGLDNICSIYN 125 + + P + V G D + +++ Sbjct: 487 CIGAVWHPHETSKVITCGWDGLIKLWD 513 >5YZG-W nrPDB Length = 579 Score = 214 bits (544), Expect = 6e-56, Method: Composition-based stats. Identities = 62/310 (20%), Positives = 108/310 (34%), Gaps = 18/310 (5%) Query: 43 IQMRTRRTLRGHLAKIYAMH-WGTDSRLLVSASQDGKLIIWDSYTTN-KVHAIPLRSSWV 100 + + GH + A+ + LL+S S D K+ +W+ Y + S V Sbjct: 276 LPKKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAV 335 Query: 101 MTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDD----NQ 156 + +G D +++ +T + R + C +F D N Sbjct: 336 RDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNR-----KVPYCVKFNPDEDKQNL 390 Query: 157 IVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREG 216 V D WDI +G+ + H G V ++ + R FVS + D S ++W+ Sbjct: 391 FVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIP 450 Query: 217 -MCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFD----LRADQELMTYSHDNIIC 271 + + A+ PNG A S D +F R +++ + H Sbjct: 451 VDFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGY 510 Query: 272 GITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTD-DGMAVATG 330 V FS +++G + N+WD HD + V T Sbjct: 511 AC-QVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETSKVITC 569 Query: 331 SWDSFLKIWN 340 WD +K+W+ Sbjct: 570 GWDGLIKLWD 579 Score = 64.3 bits (155), Expect = 7e-11, Method: Composition-based stats. Identities = 17/87 (19%), Positives = 34/87 (39%), Gaps = 3/87 (3%) Query: 42 RIQMRTRRTLRGH--LAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSW 99 R ++ ++ +GH + + D ++S +GKL IWD TT Sbjct: 493 RFRLNKKKIFKGHMVAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKV 552 Query: 100 VMTCAYAPS-GNYVACGGLDNICSIYN 125 + + P + V G D + +++ Sbjct: 553 CIGAVWHPHETSKVITCGWDGLIKLWD 579 >6HHQ-h nrPDB Length = 319 Score = 213 bits (543), Expect = 6e-56, Method: Composition-based stats. Identities = 75/317 (23%), Positives = 123/317 (38%), Gaps = 30/317 (9%) Query: 45 MRTRRTLRGHLAKIYAMHWGT-DSRLLVSASQDGKLIIW-----DSYTTNKVHAIPLRSS 98 + R TL GH + ++ LL+SAS+D LI W D V + S Sbjct: 7 LVLRGTLEGHNGWVTSLATSAGQPNLLLSASRDKTLISWKLTGDDQKFGVPVRSFKGHSH 66 Query: 99 WVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRF-LDDNQI 157 V C G Y D ++++ T E + GH + + I Sbjct: 67 IVQDCTLTADGAYALSASWDKTLRLWDVATGE----TYQRFVGHKSDVMSVDIDKKASMI 122 Query: 158 VTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAP------DTRLFVSGACDASAKLW 211 ++ S D T +W I+ GQ T GH V + + P D+ +S D K W Sbjct: 123 ISGSRDKTIKVWTIK-GQCLATLLGHNDWVSQVRVVPNEKADDDSVTIISAGNDKMVKAW 181 Query: 212 DVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIIC 271 ++ + F GH S+IN + P+G A+ D L++L A + + T S + Sbjct: 182 NLNQFQIEADFIGHNSNINTLTASPDGTLIASAGKDGEIMLWNLAAKKAMYTLSAQDE-- 239 Query: 272 GITSVSFSKSGRLLLAGYDDFNCNVW--------DALKADRAGVLAGHDNRVSCLGVTDD 323 + S++FS + L A V+ D L+ + AG + L + D Sbjct: 240 -VFSLAFSPNRYWLAAATATG-IKVFSLDPQYLVDDLRPEFAGYSKAAEPHAVSLAWSAD 297 Query: 324 GMAVATGSWDSFLKIWN 340 G + G D+ +++W Sbjct: 298 GQTLFAGYTDNVIRVWQ 314 Score = 182 bits (461), Expect = 3e-46, Method: Composition-based stats. Identities = 58/271 (21%), Positives = 106/271 (39%), Gaps = 26/271 (9%) Query: 49 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPS 108 R+ +GH + D +SAS D L +WD T S VM+ Sbjct: 59 RSFKGHSHIVQDCTLTADGAYALSASWDKTLRLWDVATGETYQRFVGHKSDVMSVDIDKK 118 Query: 109 GNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQ-------IVTSS 161 + + G D ++ +K + L GH ++S R + + + I+++ Sbjct: 119 ASMIISGSRDKTIKVWTIKG-----QCLATLLGHNDWVSQVRVVPNEKADDDSVTIISAG 173 Query: 162 GDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQT 221 D W++ Q F GH ++ +L+ +PD L S D LW++ T Sbjct: 174 NDKMVKAWNLNQFQIEADFIGHNSNINTLTASPDGTLIASAGKDGEIMLWNLAAKKAMYT 233 Query: 222 FTGHESDINAICFFPNGNAFATGSDDATCRLF---------DLRADQELMTYSHDNIICG 272 + + ++ ++ F PN A + ++F DLR + + + + Sbjct: 234 LSA-QDEVFSLAFSPNRYWLAAATATG-IKVFSLDPQYLVDDLRPEFAGYSKAAEPHA-- 289 Query: 273 ITSVSFSKSGRLLLAGYDDFNCNVWDALKAD 303 S+++S G+ L AGY D VW + A+ Sbjct: 290 -VSLAWSADGQTLFAGYTDNVIRVWQVMTAN 319 Score = 68.9 bits (167), Expect = 3e-12, Method: Composition-based stats. Identities = 24/142 (16%), Positives = 56/142 (39%), Gaps = 7/142 (4%) Query: 37 IDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLR 96 + Q + GH + I + D L+ SA +DG++++W+ ++ + + Sbjct: 178 VKAWNLNQFQIEADFIGHNSNINTLTASPDGTLIASAGKDGEIMLWNLAAKKAMYTLSAQ 237 Query: 97 SSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHT-----GYLSCCRF 151 V + A++P+ ++A +++L + + E AG++ +S Sbjct: 238 DE-VFSLAFSPNRYWLAAATATG-IKVFSLDPQYLVDDLRPEFAGYSKAAEPHAVSLAWS 295 Query: 152 LDDNQIVTSSGDTTCALWDIET 173 D + D +W + T Sbjct: 296 ADGQTLFAGYTDNVIRVWQVMT 317 >4V6W-Ag nrPDB Length = 318 Score = 211 bits (538), Expect = 2e-55, Method: Composition-based stats. Identities = 63/263 (23%), Positives = 110/263 (41%), Gaps = 15/263 (5%) Query: 48 RRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAP 107 ++ L GH I + +D +S S D L +WD + V++ A++ Sbjct: 57 QKRLYGHSHFISDVVLSSDGNYALSGSWDQTLRLWDLAAGKTTRRFEGHTKDVLSVAFSA 116 Query: 108 SGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQ---IVTSSGDT 164 + G D ++N + + + GHT ++SC RF ++ IV+ D Sbjct: 117 DNRQIVSGSRDKTIKLWNTLA---ECKFTIQEDGHTDWVSCVRFSPNHSNPIIVSCGWDR 173 Query: 165 TCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTG 224 T +W++ + GH G + +++++PD L SG D+ A LWD+ +G T Sbjct: 174 TVKVWNLANCKLKNNHHGHNGYLNTVTVSPDGSLCTSGGKDSKALLWDLNDGKNLYTLE- 232 Query: 225 HESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTY-------SHDNIICGITSVS 277 H INA+CF PN + +++DL + + + S++ Sbjct: 233 HNDIINALCFSPNRYWLCVAYG-PSIKIWDLACKKTVEELRPEVVSPTSKADQPQCLSLA 291 Query: 278 FSKSGRLLLAGYDDFNCNVWDAL 300 +S G+ L AGY D VW Sbjct: 292 WSTDGQTLFAGYSDNTIRVWQVS 314 Score = 206 bits (523), Expect = 1e-53, Method: Composition-based stats. Identities = 74/316 (23%), Positives = 128/316 (40%), Gaps = 28/316 (8%) Query: 45 MRTRRTLRGHLAKIYAMHWGT-DSRLLVSASQDGKLIIW------DSYTTNKVHAIPLRS 97 ++ R TL GH + + D ++SAS+D LI+W D+ + S Sbjct: 5 LQLRGTLIGHNGWVTQIATNPKDPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRLYGHS 64 Query: 98 SWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQ- 156 ++ + GNY G D +++L + +R GHT + F DN+ Sbjct: 65 HFISDVVLSSDGNYALSGSWDQTLRLWDLAAG----KTTRRFEGHTKDVLSVAFSADNRQ 120 Query: 157 IVTSSGDTTCALWDI-ETGQQTTTFTGHTGDVMSLSLAPDTR--LFVSGACDASAKLWDV 213 IV+ S D T LW+ + T GHT V + +P+ + VS D + K+W++ Sbjct: 121 IVSGSRDKTIKLWNTLAECKFTIQEDGHTDWVSCVRFSPNHSNPIIVSCGWDRTVKVWNL 180 Query: 214 REGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGI 273 + GH +N + P+G+ +G D+ L+DL + L T H++I I Sbjct: 181 ANCKLKNNHHGHNGYLNTVTVSPDGSLCTSGGKDSKALLWDLNDGKNLYTLEHNDI---I 237 Query: 274 TSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVL---------AGHDNRVSCLGVTDDG 324 ++ FS + L Y + +WD L + L + DG Sbjct: 238 NALCFSPNRYWLCVAYG-PSIKIWDLACKKTVEELRPEVVSPTSKADQPQCLSLAWSTDG 296 Query: 325 MAVATGSWDSFLKIWN 340 + G D+ +++W Sbjct: 297 QTLFAGYSDNTIRVWQ 312 Score = 157 bits (398), Expect = 4e-39, Method: Composition-based stats. Identities = 50/220 (22%), Positives = 96/220 (43%), Gaps = 11/220 (5%) Query: 131 GNVRVSRELAGHTGYLSCCRFLDDNQ--IVTSSGDTTCALW------DIETGQQTTTFTG 182 +++ L GH G+++ + I+++S D T +W D G G Sbjct: 3 ETLQLRGTLIGHNGWVTQIATNPKDPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRLYG 62 Query: 183 HTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFA 242 H+ + + L+ D +SG+ D + +LWD+ G + F GH D+ ++ F + Sbjct: 63 HSHFISDVVLSSDGNYALSGSWDQTLRLWDLAAGKTTRRFEGHTKDVLSVAFSADNRQIV 122 Query: 243 TGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKS--GRLLLAGYDDFNCNVWDAL 300 +GS D T +L++ A+ T D ++ V FS + ++++ D VW+ Sbjct: 123 SGSRDKTIKLWNTLAE-CKFTIQEDGHTDWVSCVRFSPNHSNPIIVSCGWDRTVKVWNLA 181 Query: 301 KADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 GH+ ++ + V+ DG +G DS +W+ Sbjct: 182 NCKLKNNHHGHNGYLNTVTVSPDGSLCTSGGKDSKALLWD 221 Score = 137 bits (344), Expect = 8e-33, Method: Composition-based stats. Identities = 50/228 (21%), Positives = 90/228 (39%), Gaps = 21/228 (9%) Query: 40 VGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIP--LRS 97 +T R GH + ++ + D+R +VS S+D + +W++ I + Sbjct: 91 WDLAAGKTTRRFEGHTKDVLSVAFSADNRQIVSGSRDKTIKLWNTLA-ECKFTIQEDGHT 149 Query: 98 SWVMTCAYAP--SGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDN 155 WV ++P S + G D ++NL N ++ GH GYL+ D Sbjct: 150 DWVSCVRFSPNHSNPIIVSCGWDRTVKVWNL----ANCKLKNNHHGHNGYLNTVTVSPDG 205 Query: 156 QIVTSSG-DTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVR 214 + TS G D+ LWD+ G+ T H + +L +P R ++ A S K+WD+ Sbjct: 206 SLCTSGGKDSKALLWDLNDGKNLYTLE-HNDIINALCFSP-NRYWLCVAYGPSIKIWDLA 263 Query: 215 EGMCRQTF---------TGHESDINAICFFPNGNAFATGSDDATCRLF 253 + + ++ + +G G D T R++ Sbjct: 264 CKKTVEELRPEVVSPTSKADQPQCLSLAWSTDGQTLFAGYSDNTIRVW 311 Score = 63.9 bits (154), Expect = 1e-10, Method: Composition-based stats. Identities = 21/145 (14%), Positives = 48/145 (33%), Gaps = 8/145 (5%) Query: 34 TNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAI 93 + + + GH + + D L S +D K ++WD ++ + Sbjct: 172 DRTVKVWNLANCKLKNNHHGHNGYLNTVTVSPDGSLCTSGGKDSKALLWDLNDGKNLYTL 231 Query: 94 PLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTG------YLS 147 + + ++P+ ++ C I++L ++ + E+ T LS Sbjct: 232 E-HNDIINALCFSPNRYWL-CVAYGPSIKIWDLACKKTVEELRPEVVSPTSKADQPQCLS 289 Query: 148 CCRFLDDNQIVTSSGDTTCALWDIE 172 D + D T +W + Sbjct: 290 LAWSTDGQTLFAGYSDNTIRVWQVS 314 >3MKQ-A nrPDB Length = 814 Score = 210 bits (535), Expect = 6e-55, Method: Composition-based stats. Identities = 61/300 (20%), Positives = 124/300 (41%), Gaps = 15/300 (5%) Query: 43 IQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMT 102 +++ ++T ++ + + +++ G++ IW+ T +V +I + + V Sbjct: 1 MKLDIKKTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVEIWNYETQVEVRSIQVTETPVRA 60 Query: 103 CAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQ-IVTSS 161 + N++ G D ++N T E V + H Y+ +++ S Sbjct: 61 GKFIARKNWIIVGSDDFRIRVFNYNTGEKVV----DFEAHPDYIRSIAVHPTKPYVLSGS 116 Query: 162 GDTTCALWDIETGQQT-TTFTGHTGDVMSLSLAP-DTRLFVSGACDASAKLWDVREGMCR 219 D T LW+ E TF GH VM ++ P D F SG D + K+W + + Sbjct: 117 DDLTVKLWNWENNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPN 176 Query: 220 QTF-TGHESDINAICF--FPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSV 276 T TG E +N + + P+ T SDD T +++D + + T + + ++ Sbjct: 177 FTLTTGQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATL--EGHMSNVSFA 234 Query: 277 SFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGM--AVATGSWDS 334 F + ++++G +D +W++ L R C+ G +A+G +D+ Sbjct: 235 VFHPTLPIIISGSEDGTLKIWNSSTYKVEKTLNVGLERSWCIATHPTGRKNYIASG-FDN 293 Score = 190 bits (483), Expect = 6e-49, Method: Composition-based stats. Identities = 60/258 (23%), Positives = 102/258 (39%), Gaps = 10/258 (3%) Query: 88 NKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLS 147 + RS V + P+ +V I+N +T+ R + + Sbjct: 4 DIKKTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVEIWNYETQVE----VRSIQVTETPVR 59 Query: 148 CCRFL-DDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDA 206 +F+ N I+ S D +++ TG++ F H + S+++ P +SG+ D Sbjct: 60 AGKFIARKNWIIVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDL 119 Query: 207 SAKLWDVREGMCR-QTFTGHESDINAICFFP-NGNAFATGSDDATCRLFDLRADQELMTY 264 + KLW+ QTF GHE + + F P + + FA+G D T +++ L T Sbjct: 120 TVKLWNWENNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTL 179 Query: 265 SHDNIICGITSVSFSK--SGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTD 322 + G+ V + ++ DD +WD L GH + VS Sbjct: 180 T-TGQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAVFHP 238 Query: 323 DGMAVATGSWDSFLKIWN 340 + +GS D LKIWN Sbjct: 239 TLPIIISGSEDGTLKIWN 256 Score = 181 bits (460), Expect = 3e-46, Method: Composition-based stats. Identities = 53/293 (18%), Positives = 112/293 (38%), Gaps = 14/293 (4%) Query: 7 LRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTD 66 ++++K + TL + ++ R+++ + A + Sbjct: 9 FSNRSDRVKGIDFHPTEPWVLTTLY--SGRVEIWNYETQVEVRSIQVTETPVRAGKFIAR 66 Query: 67 SRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNL 126 ++ S D ++ +++ T KV ++ + A P+ YV G D ++N Sbjct: 67 KNWIIVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWNW 126 Query: 127 KTREGNVRVSRELAGHTGYLSCCRFLDDNQ--IVTSSGDTTCALWDIETGQQTTTFTGHT 184 E N + + GH ++ C F + + D T +W + GQ T FT T Sbjct: 127 ---ENNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSL--GQSTPNFTLTT 181 Query: 185 GDVMSLSLA-----PDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGN 239 G ++ PD ++ + D + K+WD + C T GH S+++ F P Sbjct: 182 GQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAVFHPTLP 241 Query: 240 AFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDF 292 +GS+D T ++++ + T + + + + +G+D+ Sbjct: 242 IIISGSEDGTLKIWNSSTYKVEKTLNVGLERSWCIATHPTGRKNYIASGFDNG 294 >5G04-R nrPDB Length = 499 Score = 210 bits (534), Expect = 8e-55, Method: Composition-based stats. Identities = 62/291 (21%), Positives = 122/291 (41%), Gaps = 22/291 (7%) Query: 61 MHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSS--WVMTCAYAPSGNYVACGGLD 118 + W + +L A D + +W + + + + + + ++ + A+ GNY+A G Sbjct: 190 VDWSS-GNVLAVA-LDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSS 247 Query: 119 NICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQ-T 177 +++++ + + R + H+ + + + + S D+ + Sbjct: 248 AEVQLWDVQQQ----KRLRNMTSHSARVGSLSWNSY-ILSSGSRSGHIHHHDVRVAEHHV 302 Query: 178 TTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGM----CRQTFTGHESDINAIC 233 T +GH+ +V L APD R SG D +W G QTFT H+ + A+ Sbjct: 303 ATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVA 362 Query: 234 FFP-NGNAFATGSD--DATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYD 290 + P N ATG D R++++ + L + +C I +S + L++G+ Sbjct: 363 WCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSIL---WSPHYKELISGHG 419 Query: 291 --DFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIW 339 +W + L GH +RV L ++ DG VA+ + D L++W Sbjct: 420 FAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470 Score = 143 bits (360), Expect = 1e-34, Method: Composition-based stats. Identities = 48/221 (21%), Positives = 83/221 (37%), Gaps = 20/221 (9%) Query: 9 QEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRR-------TLRGHLAKIYAM 61 Q+ ++L+N + + + + S I ++ G I R TL GH ++ + Sbjct: 256 QQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGL 315 Query: 62 HWGTDSRLLVSASQDGKLIIWDSYTTN----KVHAIPLRSSWVMTCAYAP-SGNYVACGG 116 W D R L S D + +W S + V A+ P N +A GG Sbjct: 316 RWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGG 375 Query: 117 --LDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSG--DTTCALWDIE 172 D I+N+ + + H+ S ++++ G +W Sbjct: 376 GTSDRHIRIWNV----CSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYP 431 Query: 173 TGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDV 213 T + GHT V+SL+++PD S A D + +LW Sbjct: 432 TMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRC 472 Score = 139 bits (350), Expect = 2e-33, Method: Composition-based stats. Identities = 54/276 (19%), Positives = 101/276 (36%), Gaps = 12/276 (4%) Query: 10 EAEQLKNQIRDAR--KACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDS 67 + EQ I K + + + Q + R + H A++ ++ W S Sbjct: 221 QMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWN--S 278 Query: 68 RLLVSASQDGKLIIWDSY-TTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNL 126 +L S S+ G + D + V + S V +AP G ++A GG DN+ +++ Sbjct: 279 YILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPS 338 Query: 127 KTREGNVRVSRELAGHTGYLSCCRFLD--DNQIVTSSG--DTTCALWDIETGQQTTTFTG 182 EG + H G + + N + T G D +W++ +G + Sbjct: 339 APGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDA 398 Query: 183 HTGDVMSLSLAPDTRLFVSGA--CDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNA 240 H+ V S+ +P + +SG +W GH S + ++ P+G Sbjct: 399 HSQ-VCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGAT 457 Query: 241 FATGSDDATCRLFDLRADQELMTYSHDNIICGITSV 276 A+ + D T RL+ + +S+ Sbjct: 458 VASAAADETLRLWRCFELDPARRREREKASAAKSSL 493 Score = 104 bits (258), Expect = 7e-23, Method: Composition-based stats. Identities = 41/208 (19%), Positives = 77/208 (37%), Gaps = 15/208 (7%) Query: 143 TGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHT--GDVMSLSLAPDTRLFV 200 YL+ + N + + D + LW +G + S++ + Sbjct: 184 DYYLNLVDWSSGNVLAVA-LDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLA 242 Query: 201 SGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLR-ADQ 259 G A +LWDV++ + T H + + ++ + N ++GS D+R A+ Sbjct: 243 VGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW--NSYILSSGSRSGHIHHHDVRVAEH 300 Query: 260 ELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKAD----RAGVLAGHDNRV 315 + T S + + ++ GR L +G +D NVW + + H V Sbjct: 301 HVATLS--GHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAV 358 Query: 316 SCLGVTD-DGMAVATGS--WDSFLKIWN 340 + +ATG D ++IWN Sbjct: 359 KAVAWCPWQSNVLATGGGTSDRHIRIWN 386 >3JAP-g nrPDB Length = 326 Score = 209 bits (531), Expect = 2e-54, Method: Composition-based stats. Identities = 82/327 (25%), Positives = 128/327 (39%), Gaps = 34/327 (10%) Query: 40 VGRIQMRTRRTLRGHLAKIYAMHWGT-DSRLLVSASQDGKLIIWDSYTTN-----KVHAI 93 I + R TL GH + ++ LLVS S+D LI W V + Sbjct: 3 SSNIMLVLRGTLEGHNGWVTSLSTSAAQPNLLVSGSRDKTLISWRLTENEQQFGVPVRSY 62 Query: 94 PLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRF-L 152 S V + GNY D ++NL T R GHTG + Sbjct: 63 KGHSHIVQDVVVSADGNYAVSASWDKTLRLWNLATGNSEAR----FVGHTGDVLSVAIDA 118 Query: 153 DDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAP---------DTRL-FVSG 202 + ++I+++S D T +W+ G GHT V + +AP D R+ FVS Sbjct: 119 NSSKIISASRDKTIRVWNTV-GDCAYVLLGHTDWVTKVRVAPKNLEDGEVDDGRITFVSA 177 Query: 203 ACDASAKLWDVREGMCR--QTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQE 260 D + W + E R F GH + IN + P+G+ A+ D +++L+ Sbjct: 178 GMDKIVRSWSLNEDSYRIEADFIGHNNYINVVQPSPDGSLAASAGKDGQIYVWNLKHKSA 237 Query: 261 LMTYSHDNIICGITSVSFSKSGRLLLAG-------YDDFNCNVWDALKADRAGVLAGHDN 313 M + + + +++FS S L A YD N + D LK + AG D Sbjct: 238 FMNFDAKDE---VFALAFSPSRFWLTAATASGIKIYDLENEVLIDELKPEFAGYTKAQDP 294 Query: 314 RVSCLGVTDDGMAVATGSWDSFLKIWN 340 L + DG + G D+ +++W Sbjct: 295 HAVSLAWSADGQTLFAGYTDNVIRVWQ 321 Score = 167 bits (424), Expect = 5e-42, Method: Composition-based stats. Identities = 52/274 (18%), Positives = 101/274 (36%), Gaps = 26/274 (9%) Query: 49 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPS 108 R+ +GH + + D VSAS D L +W+ T N + V++ A + Sbjct: 60 RSYKGHSHIVQDVVVSADGNYAVSASWDKTLRLWNLATGNSEARFVGHTGDVLSVAIDAN 119 Query: 109 GNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDN-----------QI 157 + + D ++N + L GHT +++ R N Sbjct: 120 SSKIISASRDKTIRVWNTVG-----DCAYVLLGHTDWVTKVRVAPKNLEDGEVDDGRITF 174 Query: 158 VTSSGDTTCALWDI--ETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVRE 215 V++ D W + ++ + F GH + + +PD L S D +W+++ Sbjct: 175 VSAGMDKIVRSWSLNEDSYRIEADFIGHNNYINVVQPSPDGSLAASAGKDGQIYVWNLKH 234 Query: 216 GMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHD------NI 269 F + ++ A+ F P+ + +++DL + + + Sbjct: 235 KSAFMNFDA-KDEVFALAFSPSRFWLTAATASG-IKIYDLENEVLIDELKPEFAGYTKAQ 292 Query: 270 ICGITSVSFSKSGRLLLAGYDDFNCNVWDALKAD 303 S+++S G+ L AGY D VW + A+ Sbjct: 293 DPHAVSLAWSADGQTLFAGYTDNVIRVWQVMTAN 326 >4GGA-A nrPDB Length = 420 Score = 206 bits (525), Expect = 9e-54, Method: Composition-based stats. Identities = 62/291 (21%), Positives = 122/291 (41%), Gaps = 22/291 (7%) Query: 61 MHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSS--WVMTCAYAPSGNYVACGGLD 118 + W + +L A D + +W + + + + + + ++ + A+ GNY+A G Sbjct: 111 VDWSS-GNVLAVA-LDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSS 168 Query: 119 NICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQ-T 177 +++++ + + R + H+ + + + + S D+ + Sbjct: 169 AEVQLWDVQQQ----KRLRNMTSHSARVGSLSWNSY-ILSSGSRSGHIHHHDVRVAEHHV 223 Query: 178 TTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGM----CRQTFTGHESDINAIC 233 T +GH+ +V L APD R SG D +W G QTFT H+ + A+ Sbjct: 224 ATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVA 283 Query: 234 FFP-NGNAFATGSD--DATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYD 290 + P N ATG D R++++ + L + +C I +S + L++G+ Sbjct: 284 WCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSIL---WSPHYKELISGHG 340 Query: 291 --DFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIW 339 +W + L GH +RV L ++ DG VA+ + D L++W Sbjct: 341 FAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 391 Score = 140 bits (354), Expect = 5e-34, Method: Composition-based stats. Identities = 48/221 (21%), Positives = 83/221 (37%), Gaps = 20/221 (9%) Query: 9 QEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRR-------TLRGHLAKIYAM 61 Q+ ++L+N + + + + S I ++ G I R TL GH ++ + Sbjct: 177 QQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGL 236 Query: 62 HWGTDSRLLVSASQDGKLIIWDSYTTN----KVHAIPLRSSWVMTCAYAP-SGNYVACGG 116 W D R L S D + +W S + V A+ P N +A GG Sbjct: 237 RWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGG 296 Query: 117 --LDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSG--DTTCALWDIE 172 D I+N+ + + H+ S ++++ G +W Sbjct: 297 GTSDRHIRIWNV----CSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYP 352 Query: 173 TGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDV 213 T + GHT V+SL+++PD S A D + +LW Sbjct: 353 TMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRC 393 Score = 137 bits (344), Expect = 8e-33, Method: Composition-based stats. Identities = 54/276 (19%), Positives = 101/276 (36%), Gaps = 12/276 (4%) Query: 10 EAEQLKNQIRDAR--KACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDS 67 + EQ I K + + + Q + R + H A++ ++ W S Sbjct: 142 QMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWN--S 199 Query: 68 RLLVSASQDGKLIIWDSY-TTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNL 126 +L S S+ G + D + V + S V +AP G ++A GG DN+ +++ Sbjct: 200 YILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPS 259 Query: 127 KTREGNVRVSRELAGHTGYLSCCRFLD--DNQIVTSSG--DTTCALWDIETGQQTTTFTG 182 EG + H G + + N + T G D +W++ +G + Sbjct: 260 APGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDA 319 Query: 183 HTGDVMSLSLAPDTRLFVSGA--CDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNA 240 H+ V S+ +P + +SG +W GH S + ++ P+G Sbjct: 320 HSQ-VCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGAT 378 Query: 241 FATGSDDATCRLFDLRADQELMTYSHDNIICGITSV 276 A+ + D T RL+ + +S+ Sbjct: 379 VASAAADETLRLWRCFELDPARRREREKASAAKSSL 414 Score = 102 bits (253), Expect = 3e-22, Method: Composition-based stats. Identities = 41/208 (19%), Positives = 77/208 (37%), Gaps = 15/208 (7%) Query: 143 TGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHT--GDVMSLSLAPDTRLFV 200 YL+ + N + + D + LW +G + S++ + Sbjct: 105 DYYLNLVDWSSGNVLAVA-LDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLA 163 Query: 201 SGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLR-ADQ 259 G A +LWDV++ + T H + + ++ + N ++GS D+R A+ Sbjct: 164 VGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW--NSYILSSGSRSGHIHHHDVRVAEH 221 Query: 260 ELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKAD----RAGVLAGHDNRV 315 + T S + + ++ GR L +G +D NVW + + H V Sbjct: 222 HVATLS--GHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAV 279 Query: 316 SCLGVTD-DGMAVATGS--WDSFLKIWN 340 + +ATG D ++IWN Sbjct: 280 KAVAWCPWQSNVLATGGGTSDRHIRIWN 307 >5WLC-LO nrPDB Length = 923 Score = 205 bits (522), Expect = 2e-53, Method: Composition-based stats. Identities = 70/368 (19%), Positives = 127/368 (34%), Gaps = 72/368 (19%) Query: 44 QMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNK---VHAIPLRSSWV 100 R GH I ++ W DSR +++ S+D IW + K +V Sbjct: 135 PFVRHRVHAGHFQDITSLTWSQDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYV 194 Query: 101 MTCAYAPSGNYVACGGLDNICSIYNLKTR---------------------EGNVRVSRE- 138 M ++ + D ++ R + + R++++ Sbjct: 195 MGAFFSHDQEKIYTVSKDGAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKH 254 Query: 139 -LAGHTGYLSCCRFLDDNQIVTSSG-----------DTTC-------------------- 166 + + C F +++ D T Sbjct: 255 FFYANQAKVKCVTFHPATRLLAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTVSVNQTG 314 Query: 167 -------------ALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDV 213 +++ ++ GH SL+ +PD V+ + D K+WD+ Sbjct: 315 EWLAFGSSKLGQLLVYEWQSESYILKQQGHFDSTNSLAYSPDGSRVVTASEDGKIKVWDI 374 Query: 214 REGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGI 273 G C TF H S + A+ F G + S D T R +DL + T++ Sbjct: 375 TSGFCLATFEEHTSSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRYRNFRTFT-GTERIQF 433 Query: 274 TSVSFSKSGRLLLAGYDD-FNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSW 332 ++ SG ++ AG D F+ +VW L+GH+ VSCL + + +A+ SW Sbjct: 434 NCLAVDPSGEVVCAGSLDNFDIHVWSVQTGQLLDALSGHEGPVSCLSFSQENSVLASASW 493 Query: 333 DSFLKIWN 340 D ++IW+ Sbjct: 494 DKTIRIWS 501 Score = 170 bits (431), Expect = 7e-43, Method: Composition-based stats. Identities = 52/282 (18%), Positives = 107/282 (37%), Gaps = 33/282 (11%) Query: 52 RGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNY 111 +GH ++ + D +V+AS+DGK+ +WD + + +S V +A G Sbjct: 342 QGHFDSTNSLAYSPDGSRVVTASEDGKIKVWDITSGFCLATFEEHTSSVTAVQFAKRGQV 401 Query: 112 VACGGLDNICSIYNLKTREGNVRVSRELAGHTGY-LSCCRFLDDNQIV-TSSGDT-TCAL 168 + LD ++L R R G +C ++V S D + Sbjct: 402 MFSSSLDGTVRAWDLI----RYRNFRTFTGTERIQFNCLAVDPSGEVVCAGSLDNFDIHV 457 Query: 169 WDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDV----REGMCRQTFTG 224 W ++TGQ +GH G V LS + + + S + D + ++W + ++ + + Sbjct: 458 WSVQTGQLLDALSGHEGPVSCLSFSQENSVLASASWDKTIRIWSIFGRSQQVEPIEVY-- 515 Query: 225 HESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICG------------ 272 SD+ A+ P+G A + +F++ +++ I Sbjct: 516 --SDVLALSMRPDGKEVAVSTLKGQISIFNIEDAKQVGNIDCRKDIISGRFNQDRFTAKN 573 Query: 273 ------ITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVL 308 T++ +S G ++AG ++ + ++D Sbjct: 574 SERSKFFTTIHYSFDGMAIVAGGNNNSICLYDVPNEVLLKRF 615 Score = 166 bits (421), Expect = 9e-42, Method: Composition-based stats. Identities = 63/389 (16%), Positives = 125/389 (32%), Gaps = 79/389 (20%) Query: 29 TLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTN 88 LS + N + I ++ H I A+ LL+S +DG+ I+ + N Sbjct: 29 LLSPVGNRVSVFDLINNKSFTFEYEHRKNIAAIDLNKQGTLLISIDEDGRAILVNFKARN 88 Query: 89 KVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVS-----RELAGHT 143 +H + ++P G A I+ + + + R AGH Sbjct: 89 VLHHFNFKEK-CSAVKFSPDGRLFALASG-RFLQIWKTPDVNKDRQFAPFVRHRVHAGHF 146 Query: 144 GYLSCCRFLDDNQ-IVTSSGDTTCALWDIETGQQ---TTTFTGHTGDVMSLSLAPDTRLF 199 ++ + D++ I+T+S D + +W +++ ++ TTF GH VM + D Sbjct: 147 QDITSLTWSQDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGAFFSHDQEKI 206 Query: 200 VSGACDASAKLW-----------------------DVREGMC----RQTFTGHESDINAI 232 + + D + +W D+ + + F +++ + + Sbjct: 207 YTVSKDGAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQAKVKCV 266 Query: 233 CFFPNGNAFATGSDDATCRLFDL----------------------RADQEL--------- 261 F P A G RL+DL + + L Sbjct: 267 TFHPATRLLAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTVSVNQTGEWLAFGSSKLGQ 326 Query: 262 ----------MTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGH 311 S+++S G ++ +D VWD H Sbjct: 327 LLVYEWQSESYILKQQGHFDSTNSLAYSPDGSRVVTASEDGKIKVWDITSGFCLATFEEH 386 Query: 312 DNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 + V+ + G + + S D ++ W+ Sbjct: 387 TSSVTAVQFAKRGQVMFSSSLDGTVRAWD 415 Score = 123 bits (308), Expect = 1e-28, Method: Composition-based stats. Identities = 62/325 (19%), Positives = 118/325 (36%), Gaps = 42/325 (12%) Query: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPL-RSSWVMTCAYAPS 108 T H + + A+ + +++ S+S DG + WD A PS Sbjct: 382 TFEEHTSSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVDPS 441 Query: 109 GNYVACGGLDNI-CSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIV-TSSGDTTC 166 G V G LDN +++++T + + L+GH G +SC F +N ++ ++S D T Sbjct: 442 GEVVCAGSLDNFDIHVWSVQTGQ----LLDALSGHEGPVSCLSFSQENSVLASASWDKTI 497 Query: 167 ALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHE 226 +W I Q DV++LS+ PD + ++++ + + Sbjct: 498 RIWSIFGRSQQVEPIEVYSDVLALSMRPDGKEVAVSTLKGQISIFNIEDAKQVGNIDCRK 557 Query: 227 SDI--------------------NAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSH 266 I I + +G A G ++ + L+D+ + L + Sbjct: 558 DIISGRFNQDRFTAKNSERSKFFTTIHYSFDGMAIVAGGNNNSICLYDVPNEVLLKRFIV 617 Query: 267 DNIICGITSVSFSKSGRLLLAGYDDF------NCNVWDALKADRAGVLAGH--------- 311 + ++ F S ++ AG D N ++ D + G G Sbjct: 618 SRNMALNGTLEFLNSKKMTEAGSLDLIDDAGENSDLEDRIDNSLPGSQRGGDLSTRKMRP 677 Query: 312 DNRVSCLGVTDDGMAVATGSWDSFL 336 + RV+ + + A A S + L Sbjct: 678 EVRVTSVQFSPTANAFAAASTEGLL 702 Score = 97.1 bits (240), Expect = 1e-20, Method: Composition-based stats. Identities = 41/202 (20%), Positives = 80/202 (39%), Gaps = 12/202 (5%) Query: 149 CRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASA 208 F DD + + S +++D+ + T H ++ ++ L L +S D A Sbjct: 20 ITFSDDGKQLLSPVGNRVSVFDLINNKSFTFEYEHRKNIAAIDLNKQGTLLISIDEDGRA 79 Query: 209 KLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLF---DLRADQELMTY- 264 L + + F + +A+ F P+G FA S +++ D+ D++ + Sbjct: 80 ILVNFKARNVLHHFN-FKEKCSAVKFSPDGRLFALASG-RFLQIWKTPDVNKDRQFAPFV 137 Query: 265 ---SHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADR---AGVLAGHDNRVSCL 318 H ITS+++S+ R +L D + +W ++ A GH + V Sbjct: 138 RHRVHAGHFQDITSLTWSQDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGA 197 Query: 319 GVTDDGMAVATGSWDSFLKIWN 340 + D + T S D + +W Sbjct: 198 FFSHDQEKIYTVSKDGAVFVWE 219 Score = 80.1 bits (196), Expect = 1e-15, Method: Composition-based stats. Identities = 46/275 (16%), Positives = 87/275 (31%), Gaps = 46/275 (16%) Query: 36 NIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPL 95 +I + L GH + + + ++ +L SAS D + IW + ++ Sbjct: 454 DIHVWSVQTGQLLDALSGHEGPVSCLSFSQENSVLASASWDKTIRIWSIFGRSQQVEPIE 513 Query: 96 RSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDN 155 S V+ + P G VA L SI+N++ + + +G + RF N Sbjct: 514 VYSDVLALSMRPDGKEVAVSTLKGQISIFNIEDAKQVGNIDCRKDIISGRFNQDRFTAKN 573 Query: 156 QIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVRE 215 + + ++ + D V+G + S L+DV Sbjct: 574 -------------------------SERSKFFTTIHYSFDGMAIVAGGNNNSICLYDVPN 608 Query: 216 GMCRQTF-TGHESDIN-AICFFPNGNAFATGSDDATCRLFDLRADQELM----------- 262 + + F +N + F + GS D + D + +L Sbjct: 609 EVLLKRFIVSRNMALNGTLEFLNSKKMTEAGSLD---LIDDAGENSDLEDRIDNSLPGSQ 665 Query: 263 -----TYSHDNIICGITSVSFSKSGRLLLAGYDDF 292 + +TSV FS + A + Sbjct: 666 RGGDLSTRKMRPEVRVTSVQFSPTANAFAAASTEG 700 >2YNP-A nrPDB Length = 604 Score = 205 bits (522), Expect = 2e-53, Method: Composition-based stats. Identities = 59/296 (19%), Positives = 121/296 (40%), Gaps = 14/296 (4%) Query: 43 IQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMT 102 +++ ++T ++ + + +++ G++ +W+ T +V +I + + V Sbjct: 1 MKLDIKKTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVELWNYETQVEVRSIQVTETPVRA 60 Query: 103 CAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQ-IVTSS 161 + N++ G D ++N T E V + H Y+ +++ S Sbjct: 61 GKFIARKNWIIVGSDDFRIRVFNYNTGEKVV----DFEAHPDYIRSIAVHPTKPYVLSGS 116 Query: 162 GDTTCALWDIETGQQT-TTFTGHTGDVMSLSLAP-DTRLFVSGACDASAKLWDVREGMCR 219 D T LW+ E TF GH VM ++ P D F SG D + K+W + + Sbjct: 117 DDLTVKLWNWENNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPN 176 Query: 220 QTF-TGHESDINAICF--FPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSV 276 T TG E +N + + P+ T SDD T +++D + + T + + ++ Sbjct: 177 FTLTTGQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATL--EGHMSNVSFA 234 Query: 277 SFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGM--AVATG 330 F + ++++G +D +W++ L R C+ G +A+G Sbjct: 235 VFHPTLPIIISGSEDGTLKIWNSSTYKVEKTLNVGLERSWCIATHPTGRKNYIASG 290 Score = 186 bits (471), Expect = 1e-47, Method: Composition-based stats. Identities = 59/258 (22%), Positives = 102/258 (39%), Gaps = 10/258 (3%) Query: 88 NKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLS 147 + RS V + P+ +V ++N +T+ R + + Sbjct: 4 DIKKTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVELWNYETQVE----VRSIQVTETPVR 59 Query: 148 CCRFL-DDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDA 206 +F+ N I+ S D +++ TG++ F H + S+++ P +SG+ D Sbjct: 60 AGKFIARKNWIIVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDL 119 Query: 207 SAKLWDVREGMCR-QTFTGHESDINAICFFP-NGNAFATGSDDATCRLFDLRADQELMTY 264 + KLW+ QTF GHE + + F P + + FA+G D T +++ L T Sbjct: 120 TVKLWNWENNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTL 179 Query: 265 SHDNIICGITSVSFSK--SGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTD 322 + G+ V + ++ DD +WD L GH + VS Sbjct: 180 T-TGQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAVFHP 238 Query: 323 DGMAVATGSWDSFLKIWN 340 + +GS D LKIWN Sbjct: 239 TLPIIISGSEDGTLKIWN 256 Score = 177 bits (450), Expect = 4e-45, Method: Composition-based stats. Identities = 50/266 (18%), Positives = 104/266 (39%), Gaps = 12/266 (4%) Query: 34 TNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAI 93 + ++ R+++ + A + ++ S D ++ +++ T KV Sbjct: 34 SGRVELWNYETQVEVRSIQVTETPVRAGKFIARKNWIIVGSDDFRIRVFNYNTGEKVVDF 93 Query: 94 PLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLD 153 ++ + A P+ YV G D ++N E N + + GH ++ C F Sbjct: 94 EAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWNW---ENNWALEQTFEGHEHFVMCVAFNP 150 Query: 154 DNQ--IVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLA-----PDTRLFVSGACDA 206 + + D T +W + GQ T FT TG ++ PD ++ + D Sbjct: 151 KDPSTFASGCLDRTVKVWSL--GQSTPNFTLTTGQERGVNYVDYYPLPDKPYMITASDDL 208 Query: 207 SAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSH 266 + K+WD + C T GH S+++ F P +GS+D T ++++ + T + Sbjct: 209 TIKIWDYQTKSCVATLEGHMSNVSFAVFHPTLPIIISGSEDGTLKIWNSSTYKVEKTLNV 268 Query: 267 DNIICGITSVSFSKSGRLLLAGYDDF 292 + + + +G+D+ Sbjct: 269 GLERSWCIATHPTGRKNYIASGFDNG 294 >5LCW-Q nrPDB Length = 374 Score = 204 bits (520), Expect = 3e-53, Method: Composition-based stats. Identities = 62/291 (21%), Positives = 122/291 (41%), Gaps = 22/291 (7%) Query: 61 MHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSS--WVMTCAYAPSGNYVACGGLD 118 + W + +L A D + +W + + + + + + ++ + A+ GNY+A G Sbjct: 65 VDWSS-GNVLAVA-LDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSS 122 Query: 119 NICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQ-T 177 +++++ + + R + H+ + + + + S D+ + Sbjct: 123 AEVQLWDVQQQ----KRLRNMTSHSARVGSLSWNSY-ILSSGSRSGHIHHHDVRVAEHHV 177 Query: 178 TTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGM----CRQTFTGHESDINAIC 233 T +GH+ +V L APD R SG D +W G QTFT H+ + A+ Sbjct: 178 ATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVA 237 Query: 234 FFP-NGNAFATGSD--DATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYD 290 + P N ATG D R++++ + L + +C I +S + L++G+ Sbjct: 238 WCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSIL---WSPHYKELISGHG 294 Query: 291 --DFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIW 339 +W + L GH +RV L ++ DG VA+ + D L++W Sbjct: 295 FAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 345 Score = 139 bits (351), Expect = 1e-33, Method: Composition-based stats. Identities = 48/221 (21%), Positives = 83/221 (37%), Gaps = 20/221 (9%) Query: 9 QEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRR-------TLRGHLAKIYAM 61 Q+ ++L+N + + + + S I ++ G I R TL GH ++ + Sbjct: 131 QQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGL 190 Query: 62 HWGTDSRLLVSASQDGKLIIWDSYTTN----KVHAIPLRSSWVMTCAYAP-SGNYVACGG 116 W D R L S D + +W S + V A+ P N +A GG Sbjct: 191 RWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGG 250 Query: 117 --LDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSG--DTTCALWDIE 172 D I+N+ + + H+ S ++++ G +W Sbjct: 251 GTSDRHIRIWNV----CSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYP 306 Query: 173 TGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDV 213 T + GHT V+SL+++PD S A D + +LW Sbjct: 307 TMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRC 347 Score = 135 bits (341), Expect = 2e-32, Method: Composition-based stats. Identities = 54/276 (19%), Positives = 101/276 (36%), Gaps = 12/276 (4%) Query: 10 EAEQLKNQIRDAR--KACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDS 67 + EQ I K + + + Q + R + H A++ ++ W S Sbjct: 96 QMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWN--S 153 Query: 68 RLLVSASQDGKLIIWDSY-TTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNL 126 +L S S+ G + D + V + S V +AP G ++A GG DN+ +++ Sbjct: 154 YILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPS 213 Query: 127 KTREGNVRVSRELAGHTGYLSCCRFLD--DNQIVTSSG--DTTCALWDIETGQQTTTFTG 182 EG + H G + + N + T G D +W++ +G + Sbjct: 214 APGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDA 273 Query: 183 HTGDVMSLSLAPDTRLFVSGA--CDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNA 240 H+ V S+ +P + +SG +W GH S + ++ P+G Sbjct: 274 HSQ-VCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGAT 332 Query: 241 FATGSDDATCRLFDLRADQELMTYSHDNIICGITSV 276 A+ + D T RL+ + +S+ Sbjct: 333 VASAAADETLRLWRCFELDPARRREREKASAAKSSL 368 Score = 101 bits (251), Expect = 6e-22, Method: Composition-based stats. Identities = 41/208 (19%), Positives = 77/208 (37%), Gaps = 15/208 (7%) Query: 143 TGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHT--GDVMSLSLAPDTRLFV 200 YL+ + N + + D + LW +G + S++ + Sbjct: 59 DYYLNLVDWSSGNVLAVA-LDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLA 117 Query: 201 SGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLR-ADQ 259 G A +LWDV++ + T H + + ++ + N ++GS D+R A+ Sbjct: 118 VGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW--NSYILSSGSRSGHIHHHDVRVAEH 175 Query: 260 ELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKAD----RAGVLAGHDNRV 315 + T S + + ++ GR L +G +D NVW + + H V Sbjct: 176 HVATLS--GHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAV 233 Query: 316 SCLGVTD-DGMAVATGS--WDSFLKIWN 340 + +ATG D ++IWN Sbjct: 234 KAVAWCPWQSNVLATGGGTSDRHIRIWN 261 >5L9T-R nrPDB Length = 493 Score = 203 bits (516), Expect = 1e-52, Method: Composition-based stats. Identities = 67/289 (23%), Positives = 116/289 (40%), Gaps = 19/289 (6%) Query: 61 MHWGTDSRLLVSASQDGKLIIWDSYTTNKVH--AIPLRSSWVMTCAYAPSGNYVACGGLD 118 + W + + ++S + +W + T+ + + V + ++ GN VA G Sbjct: 193 VDWSSLN--VLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHK 250 Query: 119 NICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETG--QQ 176 I++ + L GHT + + + Q+ + S D DI T Q Sbjct: 251 GFVQIWDAAAG----KKLSMLEGHTARVGALAWNAE-QLSSGSRDRMILQRDIRTPPLQS 305 Query: 177 TTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFP 236 GH +V L + D +L SG D +W+ Q +T H + + AI + P Sbjct: 306 ERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSP 365 Query: 237 NGN-AFATGS--DDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLA--GYDD 291 + + A+G D R ++ Q L + +C +++SK L++ GY Sbjct: 366 HQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCN---LAWSKHANELVSTHGYSQ 422 Query: 292 FNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 VW + L GH RV L ++ DG A+ TG+ D L+ WN Sbjct: 423 NQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWN 471 Score = 138 bits (348), Expect = 3e-33, Method: Composition-based stats. Identities = 40/255 (15%), Positives = 94/255 (36%), Gaps = 13/255 (5%) Query: 56 AKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACG 115 + ++ W L+ + G + IWD+ K+ + ++ V A+ + ++ G Sbjct: 230 DSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAW--NAEQLSSG 287 Query: 116 GLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIV-TSSGDTTCALWDIETG 174 D + +++T ++ R L GH + ++ D+Q++ + D +W+ + Sbjct: 288 SRDRMILQRDIRTP--PLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSL 345 Query: 175 QQTTTFTGHTGDVMSLSLAPDTR-LFVSGA--CDASAKLWDVREGMCRQTFTGHESDINA 231 +T H V +++ +P L SG D + W+ G Q N Sbjct: 346 SPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCN- 404 Query: 232 ICFFPNGNAFAT--GSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGY 289 + + + N + G ++ + ++ + + ++ S G ++ G Sbjct: 405 LAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLT--GHSYRVLYLAMSPDGEAIVTGA 462 Query: 290 DDFNCNVWDALKADR 304 D W+ R Sbjct: 463 GDETLRFWNVFSKTR 477 Score = 120 bits (302), Expect = 7e-28, Method: Composition-based stats. Identities = 42/176 (23%), Positives = 81/176 (46%), Gaps = 9/176 (5%) Query: 43 IQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMT 102 +++ R L+GH ++ + W TD +LL S D KL++W+ + + V + V Sbjct: 301 PPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKA 360 Query: 103 CAYAPSGN-YVACGG--LDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVT 159 A++P + +A GG D +N T + + + + + N++V+ Sbjct: 361 IAWSPHQHGLLASGGGTADRCIRFWNTLTGQP----LQCIDTGSQVCNLAWSKHANELVS 416 Query: 160 SSG--DTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDV 213 + G +W + Q TGH+ V+ L+++PD V+GA D + + W+V Sbjct: 417 THGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNV 472 Score = 120 bits (300), Expect = 1e-27, Method: Composition-based stats. Identities = 44/227 (19%), Positives = 79/227 (34%), Gaps = 15/227 (6%) Query: 37 IDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTT--NKVHAIP 94 + + L GH A++ A+ W + L S S+D ++ D T + Sbjct: 253 VQIWDAAAGKKLSMLEGHTARVGALAWNAEQ--LSSGSRDRMILQRDIRTPPLQSERRLQ 310 Query: 95 LRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDD 154 V ++ +A GG DN ++N + + ++ H + + Sbjct: 311 GHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSS----LSPVQQYTEHLAAVKAIAWSPH 366 Query: 155 NQIVTSSG----DTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVS--GACDASA 208 + +SG D W+ TGQ V +L+ + VS G Sbjct: 367 QHGLLASGGGTADRCIRFWNTLTGQPLQCIDT-GSQVCNLAWSKHANELVSTHGYSQNQI 425 Query: 209 KLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDL 255 +W TGH + + P+G A TG+ D T R +++ Sbjct: 426 LVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNV 472 Score = 50.8 bits (120), Expect = 7e-07, Method: Composition-based stats. Identities = 14/79 (17%), Positives = 33/79 (41%), Gaps = 2/79 (2%) Query: 58 IYAMHWGTDSRLLVS--ASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACG 115 + + W + LVS ++++W + +V + S V+ A +P G + G Sbjct: 402 VCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTG 461 Query: 116 GLDNICSIYNLKTREGNVR 134 D +N+ ++ + + Sbjct: 462 AGDETLRFWNVFSKTRSTK 480 Score = 40.4 bits (93), Expect = 0.001, Method: Composition-based stats. Identities = 11/61 (18%), Positives = 22/61 (36%) Query: 28 ATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTT 87 +T N I + L GH ++ + D +V+ + D L W+ ++ Sbjct: 416 STHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSK 475 Query: 88 N 88 Sbjct: 476 T 476 >5I2T-A nrPDB Length = 742 Score = 202 bits (515), Expect = 1e-52, Method: Composition-based stats. Identities = 70/368 (19%), Positives = 127/368 (34%), Gaps = 72/368 (19%) Query: 44 QMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNK---VHAIPLRSSWV 100 R GH I ++ W DSR +++ S+D IW + K +V Sbjct: 160 PFVRHRVHAGHFQDITSLTWSQDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYV 219 Query: 101 MTCAYAPSGNYVACGGLDNICSIYNLKTR---------------------EGNVRVSRE- 138 M ++ + D ++ R + + R++++ Sbjct: 220 MGAFFSHDQEKIYTVSKDGAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKH 279 Query: 139 -LAGHTGYLSCCRFLDDNQIVTSSG-----------DTTC-------------------- 166 + + C F +++ D T Sbjct: 280 FFYANQAKVKCVTFHPATRLLAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTVSVNQTG 339 Query: 167 -------------ALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDV 213 +++ ++ GH SL+ +PD V+ + D K+WD+ Sbjct: 340 EWLAFGSSKLGQLLVYEWQSESYILKQQGHFDSTNSLAYSPDGSRVVTASEDGKIKVWDI 399 Query: 214 REGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGI 273 G C TF H S + A+ F G + S D T R +DL + T++ Sbjct: 400 TSGFCLATFEEHTSSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRYRNFRTFT-GTERIQF 458 Query: 274 TSVSFSKSGRLLLAGYDD-FNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSW 332 ++ SG ++ AG D F+ +VW L+GH+ VSCL + + +A+ SW Sbjct: 459 NCLAVDPSGEVVCAGSLDNFDIHVWSVQTGQLLDALSGHEGPVSCLSFSQENSVLASASW 518 Query: 333 DSFLKIWN 340 D ++IW+ Sbjct: 519 DKTIRIWS 526 Score = 168 bits (425), Expect = 3e-42, Method: Composition-based stats. Identities = 52/282 (18%), Positives = 107/282 (37%), Gaps = 33/282 (11%) Query: 52 RGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNY 111 +GH ++ + D +V+AS+DGK+ +WD + + +S V +A G Sbjct: 367 QGHFDSTNSLAYSPDGSRVVTASEDGKIKVWDITSGFCLATFEEHTSSVTAVQFAKRGQV 426 Query: 112 VACGGLDNICSIYNLKTREGNVRVSRELAGHTGY-LSCCRFLDDNQIV-TSSGDT-TCAL 168 + LD ++L R R G +C ++V S D + Sbjct: 427 MFSSSLDGTVRAWDLI----RYRNFRTFTGTERIQFNCLAVDPSGEVVCAGSLDNFDIHV 482 Query: 169 WDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDV----REGMCRQTFTG 224 W ++TGQ +GH G V LS + + + S + D + ++W + ++ + + Sbjct: 483 WSVQTGQLLDALSGHEGPVSCLSFSQENSVLASASWDKTIRIWSIFGRSQQVEPIEVY-- 540 Query: 225 HESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICG------------ 272 SD+ A+ P+G A + +F++ +++ I Sbjct: 541 --SDVLALSMRPDGKEVAVSTLKGQISIFNIEDAKQVGNIDCRKDIISGRFNQDRFTAKN 598 Query: 273 ------ITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVL 308 T++ +S G ++AG ++ + ++D Sbjct: 599 SERSKFFTTIHYSFDGMAIVAGGNNNSICLYDVPNEVLLKRF 640 Score = 164 bits (415), Expect = 5e-41, Method: Composition-based stats. Identities = 63/389 (16%), Positives = 125/389 (32%), Gaps = 79/389 (20%) Query: 29 TLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTN 88 LS + N + I ++ H I A+ LL+S +DG+ I+ + N Sbjct: 54 LLSPVGNRVSVFDLINNKSFTFEYEHRKNIAAIDLNKQGTLLISIDEDGRAILVNFKARN 113 Query: 89 KVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVS-----RELAGHT 143 +H + ++P G A I+ + + + R AGH Sbjct: 114 VLHHFNFKEK-CSAVKFSPDGRLFALASG-RFLQIWKTPDVNKDRQFAPFVRHRVHAGHF 171 Query: 144 GYLSCCRFLDDNQ-IVTSSGDTTCALWDIETGQQ---TTTFTGHTGDVMSLSLAPDTRLF 199 ++ + D++ I+T+S D + +W +++ ++ TTF GH VM + D Sbjct: 172 QDITSLTWSQDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGAFFSHDQEKI 231 Query: 200 VSGACDASAKLW-----------------------DVREGMC----RQTFTGHESDINAI 232 + + D + +W D+ + + F +++ + + Sbjct: 232 YTVSKDGAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQAKVKCV 291 Query: 233 CFFPNGNAFATGSDDATCRLFDL----------------------RADQEL--------- 261 F P A G RL+DL + + L Sbjct: 292 TFHPATRLLAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTVSVNQTGEWLAFGSSKLGQ 351 Query: 262 ----------MTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGH 311 S+++S G ++ +D VWD H Sbjct: 352 LLVYEWQSESYILKQQGHFDSTNSLAYSPDGSRVVTASEDGKIKVWDITSGFCLATFEEH 411 Query: 312 DNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 + V+ + G + + S D ++ W+ Sbjct: 412 TSSVTAVQFAKRGQVMFSSSLDGTVRAWD 440 Score = 121 bits (304), Expect = 4e-28, Method: Composition-based stats. Identities = 62/325 (19%), Positives = 118/325 (36%), Gaps = 42/325 (12%) Query: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPL-RSSWVMTCAYAPS 108 T H + + A+ + +++ S+S DG + WD A PS Sbjct: 407 TFEEHTSSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVDPS 466 Query: 109 GNYVACGGLDNI-CSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIV-TSSGDTTC 166 G V G LDN +++++T + + L+GH G +SC F +N ++ ++S D T Sbjct: 467 GEVVCAGSLDNFDIHVWSVQTGQ----LLDALSGHEGPVSCLSFSQENSVLASASWDKTI 522 Query: 167 ALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHE 226 +W I Q DV++LS+ PD + ++++ + + Sbjct: 523 RIWSIFGRSQQVEPIEVYSDVLALSMRPDGKEVAVSTLKGQISIFNIEDAKQVGNIDCRK 582 Query: 227 SDI--------------------NAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSH 266 I I + +G A G ++ + L+D+ + L + Sbjct: 583 DIISGRFNQDRFTAKNSERSKFFTTIHYSFDGMAIVAGGNNNSICLYDVPNEVLLKRFIV 642 Query: 267 DNIICGITSVSFSKSGRLLLAGYDDF------NCNVWDALKADRAGVLAGH--------- 311 + ++ F S ++ AG D N ++ D + G G Sbjct: 643 SRNMALNGTLEFLNSKKMTEAGSLDLIDDAGENSDLEDRIDNSLPGSQRGGDLSTRKMRP 702 Query: 312 DNRVSCLGVTDDGMAVATGSWDSFL 336 + RV+ + + A A S + L Sbjct: 703 EVRVTSVQFSPTANAFAAASTEGLL 727 Score = 95.9 bits (237), Expect = 2e-20, Method: Composition-based stats. Identities = 41/202 (20%), Positives = 80/202 (39%), Gaps = 12/202 (5%) Query: 149 CRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASA 208 F DD + + S +++D+ + T H ++ ++ L L +S D A Sbjct: 45 ITFSDDGKQLLSPVGNRVSVFDLINNKSFTFEYEHRKNIAAIDLNKQGTLLISIDEDGRA 104 Query: 209 KLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLF---DLRADQELMTY- 264 L + + F + +A+ F P+G FA S +++ D+ D++ + Sbjct: 105 ILVNFKARNVLHHFN-FKEKCSAVKFSPDGRLFALASG-RFLQIWKTPDVNKDRQFAPFV 162 Query: 265 ---SHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADR---AGVLAGHDNRVSCL 318 H ITS+++S+ R +L D + +W ++ A GH + V Sbjct: 163 RHRVHAGHFQDITSLTWSQDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGA 222 Query: 319 GVTDDGMAVATGSWDSFLKIWN 340 + D + T S D + +W Sbjct: 223 FFSHDQEKIYTVSKDGAVFVWE 244 Score = 78.6 bits (192), Expect = 3e-15, Method: Composition-based stats. Identities = 46/275 (16%), Positives = 87/275 (31%), Gaps = 46/275 (16%) Query: 36 NIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPL 95 +I + L GH + + + ++ +L SAS D + IW + ++ Sbjct: 479 DIHVWSVQTGQLLDALSGHEGPVSCLSFSQENSVLASASWDKTIRIWSIFGRSQQVEPIE 538 Query: 96 RSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDN 155 S V+ + P G VA L SI+N++ + + +G + RF N Sbjct: 539 VYSDVLALSMRPDGKEVAVSTLKGQISIFNIEDAKQVGNIDCRKDIISGRFNQDRFTAKN 598 Query: 156 QIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVRE 215 + + ++ + D V+G + S L+DV Sbjct: 599 -------------------------SERSKFFTTIHYSFDGMAIVAGGNNNSICLYDVPN 633 Query: 216 GMCRQTF-TGHESDIN-AICFFPNGNAFATGSDDATCRLFDLRADQELM----------- 262 + + F +N + F + GS D + D + +L Sbjct: 634 EVLLKRFIVSRNMALNGTLEFLNSKKMTEAGSLD---LIDDAGENSDLEDRIDNSLPGSQ 690 Query: 263 -----TYSHDNIICGITSVSFSKSGRLLLAGYDDF 292 + +TSV FS + A + Sbjct: 691 RGGDLSTRKMRPEVRVTSVQFSPTANAFAAASTEG 725 >3JB9-L nrPDB Length = 340 Score = 199 bits (506), Expect = 1e-51, Method: Composition-based stats. Identities = 66/338 (19%), Positives = 133/338 (39%), Gaps = 16/338 (4%) Query: 8 RQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDS 67 R+E+E N R D++L + + + + + GH A++ + Sbjct: 4 RKESESATNGHLVKRIRIQDSSLITEGSVLQRTSDLNVPNLQMF-GHTAEVLVARFDPSG 62 Query: 68 RLLVSASQDGKLIIWDSYTTNKVH-AIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNL 126 S D ++++W+ + K + + + ++ V C D ++ Sbjct: 63 SYFASGGMDRQILLWNVFGDVKNYGVLNGCKGAITDLQWSRDSRVVYCSSSDTHLMSWDA 122 Query: 127 KTREGNVRVSRELAGHTGYLSCCRFLD--DNQIVTSSGDTTCALWDIETGQQTTTFTGHT 184 + + R+ GH G ++ L + + S D T +WD + T Sbjct: 123 VSGQK----IRKHKGHAGVVNALDVLKVGSELLTSVSDDCTMKVWDSRSKDCIKTIE-EK 177 Query: 185 GDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATG 244 + ++++A G D + K+WD+R C GH+ I ++ +G++ + Sbjct: 178 YPLTAVAIAQQGTQVFIGGIDGAIKIWDLRNNHCSHVLKGHKDIITSLAISKDGSSLLSN 237 Query: 245 SDDATCRLFDLR----ADQELMTYSH--DNIICGITSVSFSKSGRLLLAGYDDFNCNVWD 298 S D T R+FD++ A ++L + + V++S++ R + AG D N VW Sbjct: 238 SMDNTVRIFDVKPFASAQRQLQIFEGAIHGQEHNLLGVAWSRNSRFVGAGSSDKNVYVWS 297 Query: 299 ALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFL 336 A D VL GH+ V+ + + + S D + Sbjct: 298 A-TGDLRYVLPGHEGSVNHVDFHPHQDIILSCSSDRTI 334 Score = 160 bits (404), Expect = 1e-39, Method: Composition-based stats. Identities = 63/256 (24%), Positives = 114/256 (44%), Gaps = 16/256 (6%) Query: 95 LRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDD 154 ++ V+ + PSG+Y A GG+D ++N+ G+V+ L G G ++ ++ D Sbjct: 48 GHTAEVLVARFDPSGSYFASGGMDRQILLWNVF---GDVKNYGVLNGCKGAITDLQWSRD 104 Query: 155 NQIVTSSG-DTTCALWDIETGQQTTTFTGHTGDVMSLSL-APDTRLFVSGACDASAKLWD 212 +++V S DT WD +GQ+ GH G V +L + + L S + D + K+WD Sbjct: 105 SRVVYCSSSDTHLMSWDAVSGQKIRKHKGHAGVVNALDVLKVGSELLTSVSDDCTMKVWD 164 Query: 213 VREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICG 272 R C +T + + A+ G G D +++DLR + ++ Sbjct: 165 SRSKDCIKTIEE-KYPLTAVAIAQQGTQVFIGGIDGAIKIWDLRNNHC--SHVLKGHKDI 221 Query: 273 ITSVSFSKSGRLLLAGYDDFNCNVWDALKADRA--------GVLAGHDNRVSCLGVTDDG 324 ITS++ SK G LL+ D ++D A G + G ++ + + + + Sbjct: 222 ITSLAISKDGSSLLSNSMDNTVRIFDVKPFASAQRQLQIFEGAIHGQEHNLLGVAWSRNS 281 Query: 325 MAVATGSWDSFLKIWN 340 V GS D + +W+ Sbjct: 282 RFVGAGSSDKNVYVWS 297 Score = 131 bits (330), Expect = 3e-31, Method: Composition-based stats. Identities = 41/262 (15%), Positives = 94/262 (35%), Gaps = 16/262 (6%) Query: 44 QMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTC 103 ++ L G I + W DSR++ +S D L+ WD+ + K+ + V Sbjct: 82 DVKNYGVLNGCKGAITDLQWSRDSRVVYCSSSDTHLMSWDAVSGQKIRKHKGHAGVVNAL 141 Query: 104 AYAPSGN-YVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSG 162 G+ + D +++ ++++ + + ++ Q+ Sbjct: 142 DVLKVGSELLTSVSDDCTMKVWDSRSKDCIKTIEEKYPLTAVAIAQ----QGTQVFIGGI 197 Query: 163 DTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVRE-GMCRQT 221 D +WD+ + GH + SL+++ D +S + D + +++DV+ ++ Sbjct: 198 DGAIKIWDLRNNHCSHVLKGHKDIITSLAISKDGSSLLSNSMDNTVRIFDVKPFASAQRQ 257 Query: 222 FTGHESDIN-------AICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGIT 274 E I+ + + N GS D ++ D + H+ + Sbjct: 258 LQIFEGAIHGQEHNLLGVAWSRNSRFVGAGSSDKNVYVWSATGDLRYVLPGHEG---SVN 314 Query: 275 SVSFSKSGRLLLAGYDDFNCNV 296 V F ++L+ D + Sbjct: 315 HVDFHPHQDIILSCSSDRTIFL 336 Score = 46.2 bits (108), Expect = 2e-05, Method: Composition-based stats. Identities = 18/85 (21%), Positives = 29/85 (34%), Gaps = 1/85 (1%) Query: 257 ADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDAL-KADRAGVLAGHDNRV 315 +D + + F SG +G D +W+ GVL G + Sbjct: 37 SDLNVPNLQMFGHTAEVLVARFDPSGSYFASGGMDRQILLWNVFGDVKNYGVLNGCKGAI 96 Query: 316 SCLGVTDDGMAVATGSWDSFLKIWN 340 + L + D V S D+ L W+ Sbjct: 97 TDLQWSRDSRVVYCSSSDTHLMSWD 121 >4N14-A nrPDB Length = 314 Score = 199 bits (505), Expect = 2e-51, Method: Composition-based stats. Identities = 62/291 (21%), Positives = 122/291 (41%), Gaps = 22/291 (7%) Query: 61 MHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSS--WVMTCAYAPSGNYVACGGLD 118 + W + +L A D + +W + + + + + + ++ + A+ GNY+A G Sbjct: 27 VDWSS-GNVLAVA-LDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSS 84 Query: 119 NICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQ-T 177 +++++ + + R + H+ + + + + S D+ + Sbjct: 85 AEVQLWDVQQQ----KRLRNMTSHSARVGSLSWNSY-ILSSGSRSGHIHHHDVRVAEHHV 139 Query: 178 TTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGM----CRQTFTGHESDINAIC 233 T +GH+ +V L APD R SG D +W G QTFT H+ + A+ Sbjct: 140 ATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVA 199 Query: 234 FFP-NGNAFATGSD--DATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYD 290 + P N ATG D R++++ + L + +C I +S + L++G+ Sbjct: 200 WCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSIL---WSPHYKELISGHG 256 Query: 291 --DFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIW 339 +W + L GH +RV L ++ DG VA+ + D L++W Sbjct: 257 FAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 307 Score = 135 bits (341), Expect = 2e-32, Method: Composition-based stats. Identities = 48/221 (21%), Positives = 83/221 (37%), Gaps = 20/221 (9%) Query: 9 QEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRR-------TLRGHLAKIYAM 61 Q+ ++L+N + + + + S I ++ G I R TL GH ++ + Sbjct: 93 QQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGL 152 Query: 62 HWGTDSRLLVSASQDGKLIIWDSYTTN----KVHAIPLRSSWVMTCAYAP-SGNYVACGG 116 W D R L S D + +W S + V A+ P N +A GG Sbjct: 153 RWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGG 212 Query: 117 --LDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSG--DTTCALWDIE 172 D I+N+ + + H+ S ++++ G +W Sbjct: 213 GTSDRHIRIWNV----CSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYP 268 Query: 173 TGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDV 213 T + GHT V+SL+++PD S A D + +LW Sbjct: 269 TMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRC 309 Score = 131 bits (330), Expect = 3e-31, Method: Composition-based stats. Identities = 53/253 (20%), Positives = 97/253 (38%), Gaps = 12/253 (4%) Query: 10 EAEQLKNQIRDAR--KACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDS 67 + EQ I K + + + Q + R + H A++ ++ W S Sbjct: 58 QMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWN--S 115 Query: 68 RLLVSASQDGKLIIWDSY-TTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNL 126 +L S S+ G + D + V + S V +AP G ++A GG DN+ +++ Sbjct: 116 YILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPS 175 Query: 127 KTREGNVRVSRELAGHTGYLSCCRFLD--DNQIVTSSG--DTTCALWDIETGQQTTTFTG 182 EG + H G + + N + T G D +W++ +G + Sbjct: 176 APGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDA 235 Query: 183 HTGDVMSLSLAPDTRLFVSGA--CDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNA 240 H+ V S+ +P + +SG +W GH S + ++ P+G Sbjct: 236 HSQ-VCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGAT 294 Query: 241 FATGSDDATCRLF 253 A+ + D T RL+ Sbjct: 295 VASAAADETLRLW 307 Score = 131 bits (329), Expect = 4e-31, Method: Composition-based stats. Identities = 42/257 (16%), Positives = 98/257 (38%), Gaps = 18/257 (7%) Query: 58 IYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGL 117 I ++ W + L + ++ +WD ++ + S+ V + ++ + ++ G Sbjct: 66 ISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW--NSYILSSGSR 123 Query: 118 DNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQ-IVTSSGDTTCALWDIETGQ- 175 ++++ E +V L+GH+ + R+ D + + + D +W G+ Sbjct: 124 SGHIHHHDVRVAEHHV---ATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEG 180 Query: 176 ---QTTTFTGHTGDVMSLSLAPD-TRLFVSGA--CDASAKLWDVREGMCRQTFTGHESDI 229 TFT H G V +++ P + + +G D ++W+V G C H S + Sbjct: 181 GWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAH-SQV 239 Query: 230 NAICFFPNGNAFATGS--DDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLA 287 +I + P+ +G ++ ++ + S++ S G + + Sbjct: 240 CSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAEL--KGHTSRVLSLTMSPDGATVAS 297 Query: 288 GYDDFNCNVWDALKADR 304 D +W + D Sbjct: 298 AAADETLRLWRCFELDP 314 Score = 98.2 bits (243), Expect = 5e-21, Method: Composition-based stats. Identities = 41/208 (19%), Positives = 77/208 (37%), Gaps = 15/208 (7%) Query: 143 TGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHT--GDVMSLSLAPDTRLFV 200 YL+ + N + + D + LW +G + S++ + Sbjct: 21 DYYLNLVDWSSGNVLAVA-LDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLA 79 Query: 201 SGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLR-ADQ 259 G A +LWDV++ + T H + + ++ + N ++GS D+R A+ Sbjct: 80 VGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW--NSYILSSGSRSGHIHHHDVRVAEH 137 Query: 260 ELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKAD----RAGVLAGHDNRV 315 + T S + + ++ GR L +G +D NVW + + H V Sbjct: 138 HVATLS--GHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAV 195 Query: 316 SCLGVTD-DGMAVATGS--WDSFLKIWN 340 + +ATG D ++IWN Sbjct: 196 KAVAWCPWQSNVLATGGGTSDRHIRIWN 223 Score = 38.5 bits (88), Expect = 0.004, Method: Composition-based stats. Identities = 9/39 (23%), Positives = 20/39 (51%) Query: 51 LRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNK 89 L+GH +++ ++ D + SA+ D L +W + + Sbjct: 276 LKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDP 314 >5Z56-q nrPDB Length = 504 Score = 196 bits (497), Expect = 1e-50, Method: Composition-based stats. Identities = 69/338 (20%), Positives = 131/338 (38%), Gaps = 15/338 (4%) Query: 10 EAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLA---KIYAMHWGT- 65 + Q K + + T+ + + + + + H A I A+ Sbjct: 174 QKLQDKATVLTTERKKRGKTVPEELVKPEELSKYRQVASHV-GLHSASIPGILALDLCPS 232 Query: 66 DSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYN 125 D+ +++ D ++++D + + + + V + + PS + V D I++ Sbjct: 233 DTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWS 292 Query: 126 LKTREGNVRVSRELAGHTGYLSCCRFL-DDNQIVTSSGDTTCALWDIETGQQTTTFTGHT 184 + N + + H ++ + +++SS D A DI+TG+ T T T Sbjct: 293 V----PNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDET 348 Query: 185 GDV--MSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFA 242 PD +F +G D+ K+WD++E F GH I +I F NG A Sbjct: 349 SGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLA 408 Query: 243 TGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKA 302 T +DD++ +L+DLR + T DN + S+ F +SG L G D + + Sbjct: 409 TAADDSSVKLWDLRKLKNFKTLQLDN-NFEVKSLIFDQSGTYLALGGTDVQIYI--CKQW 465 Query: 303 DRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 H + + +A+ D LK ++ Sbjct: 466 TEILHFTEHSGLTTGVAFGHHAKFIASTGMDRSLKFYS 503 Score = 141 bits (356), Expect = 3e-34, Method: Composition-based stats. Identities = 53/264 (20%), Positives = 101/264 (38%), Gaps = 44/264 (16%) Query: 34 TNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAI 93 N+ + + TL+GH K+ ++ + L+ SAS D + IW + V + Sbjct: 243 DKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVV 302 Query: 94 PLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLD 153 S V + +G+Y+ D + +++T +V+ E +G + L+C +F Sbjct: 303 RAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCS--LTCAQFHP 360 Query: 154 DNQIV-TSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWD 212 D I T + D+ +WD++ F GH+G + S++ + + + A D+S KLWD Sbjct: 361 DGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWD 420 Query: 213 VREGMCRQT-----------------------------------------FTGHESDINA 231 +R+ +T FT H Sbjct: 421 LRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQIYICKQWTEILHFTEHSGLTTG 480 Query: 232 ICFFPNGNAFATGSDDATCRLFDL 255 + F + A+ D + + + L Sbjct: 481 VAFGHHAKFIASTGMDRSLKFYSL 504 Score = 70.9 bits (172), Expect = 8e-13, Method: Composition-based stats. Identities = 24/141 (17%), Positives = 49/141 (34%), Gaps = 8/141 (5%) Query: 33 ITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHA 92 + + I + GH I ++ + + L +A+ D + +WD Sbjct: 370 MDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKT 429 Query: 93 IPLRSSW-VMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRF 151 + L +++ V + + SG Y+A GG D I H+G + F Sbjct: 430 LQLDNNFEVKSLIFDQSGTYLALGGTDVQIYI------CKQWTEILHFTEHSGLTTGVAF 483 Query: 152 -LDDNQIVTSSGDTTCALWDI 171 I ++ D + + + Sbjct: 484 GHHAKFIASTGMDRSLKFYSL 504 >5WYK-BB nrPDB Length = 943 Score = 192 bits (487), Expect = 2e-49, Method: Composition-based stats. Identities = 66/325 (20%), Positives = 119/325 (36%), Gaps = 28/325 (8%) Query: 35 NNIDPVGRIQMRTRRT-LRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAI 93 DP ++T L+G + ++ D++LL +AS G L IW+ T + Sbjct: 370 EKRDPTSPAPLKTHTIELQGQRTDVRSIDISDDNKLLATASN-GSLKIWNIKTHKCIRTF 428 Query: 94 PLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRF-L 152 + +TC + P G V G + +++L + + + H + Sbjct: 429 EC--GYALTCKFLPGGLLVILGTRNGELQLFDLAS---SSLLDTIEDAHDAAIWSLDLTS 483 Query: 153 DDNQIVTSSGDTTCALWDIE---------TGQQTTTFTGH-------TGDVMSLSLAPDT 196 D ++VT S D T WD + + H T D++ + ++PD Sbjct: 484 DGKRLVTGSADKTVKFWDFKVENSLVPGTKNKFLPVLKLHHDTTLELTDDILCVRVSPDD 543 Query: 197 RLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLR 256 R D + K++ + + GH+ + +I + T S D +++ L Sbjct: 544 RYLAISLLDNTVKVFFLDSMKFYLSLYGHKLPVLSIDISFDSKMIITSSADKNIKIWGLD 603 Query: 257 ADQE-LMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRV 315 ++H + I +V F + D WD K + L H + V Sbjct: 604 FGDCHKSLFAHQD---SIMNVKFLPQSHNFFSCSKDAVVKYWDGEKFECIQKLYAHQSEV 660 Query: 316 SCLGVTDDGMAVATGSWDSFLKIWN 340 L V DG V + S D ++IW Sbjct: 661 WALAVATDGGFVVSSSHDHSIRIWE 685 Score = 168 bits (426), Expect = 3e-42, Method: Composition-based stats. Identities = 51/226 (22%), Positives = 92/226 (40%), Gaps = 21/226 (9%) Query: 53 GHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKV---------HAIPLR------- 96 H A I+++ +D + LV+ S D + WD N + + L Sbjct: 471 AHDAAIWSLDLTSDGKRLVTGSADKTVKFWDFKVENSLVPGTKNKFLPVLKLHHDTTLEL 530 Query: 97 SSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFL-DDN 155 + ++ +P Y+A LDN ++ L + ++ L GH + D Sbjct: 531 TDDILCVRVSPDDRYLAISLLDNTVKVFFLDS----MKFYLSLYGHKLPVLSIDISFDSK 586 Query: 156 QIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVRE 215 I+TSS D +W ++ G + H +M++ P + F S + DA K WD + Sbjct: 587 MIITSSADKNIKIWGLDFGDCHKSLFAHQDSIMNVKFLPQSHNFFSCSKDAVVKYWDGEK 646 Query: 216 GMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQEL 261 C Q H+S++ A+ +G + S D + R+++ DQ Sbjct: 647 FECIQKLYAHQSEVWALAVATDGGFVVSSSHDHSIRIWEETEDQVF 692 Score = 137 bits (344), Expect = 9e-33, Method: Composition-based stats. Identities = 66/372 (17%), Positives = 123/372 (33%), Gaps = 50/372 (13%) Query: 6 QLRQEAEQLKNQIRDARKACADATLSQ-----ITNNIDPVGRIQMRTRRTLRGHLAKIYA 60 ++R+E E + + ++ + I + +T R+L KI + Sbjct: 285 RIRKEEEIARGLKKREKRLKEKGLTEEEIAKSIKESYSSFILHPFQTIRSLY----KIKS 340 Query: 61 MHWGTDSRL---LVSASQDGKLIIWDSYTTN---------KVHAI--PLRSSWVMTCAYA 106 W T S LV + + + K H I + + V + + Sbjct: 341 ASWTTVSSSKLELVLTTSSNTIEYYSIPYEKRDPTSPAPLKTHTIELQGQRTDVRSIDIS 400 Query: 107 PSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQI-VTSSGDTT 165 +A + I+N+KT + R GY C+FL + + + + Sbjct: 401 DDNKLLATAS-NGSLKIWNIKTH----KCIRTFE--CGYALTCKFLPGGLLVILGTRNGE 453 Query: 166 CALWDIETGQQTTTFT-GHTGDVMSLSLAPDTRLFVSGACDASAKLWDVR---------E 215 L+D+ + T H + SL L D + V+G+ D + K WD + + Sbjct: 454 LQLFDLASSSLLDTIEDAHDAAIWSLDLTSDGKRLVTGSADKTVKFWDFKVENSLVPGTK 513 Query: 216 GMCRQTFTGH-------ESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDN 268 H DI + P+ A D T ++F L D S Sbjct: 514 NKFLPVLKLHHDTTLELTDDILCVRVSPDDRYLAISLLDNTVKVFFL--DSMKFYLSLYG 571 Query: 269 IICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVA 328 + S+ S ++++ D N +W D L H + + + Sbjct: 572 HKLPVLSIDISFDSKMIITSSADKNIKIWGLDFGDCHKSLFAHQDSIMNVKFLPQSHNFF 631 Query: 329 TGSWDSFLKIWN 340 + S D+ +K W+ Sbjct: 632 SCSKDAVVKYWD 643 Score = 118 bits (295), Expect = 4e-27, Method: Composition-based stats. Identities = 47/201 (23%), Positives = 72/201 (35%), Gaps = 21/201 (10%) Query: 153 DDNQIVTSSGDTTCALWDIETGQQTTTFT------------GHTGDVMSLSLAPDTRLFV 200 I ++ D +WDI+TG + + + L DT L Sbjct: 38 PGQLITSALED--VNIWDIKTGDLVSKLSDGLPPGASDARGAKPAECTYLEAHKDTDLLA 95 Query: 201 SGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQE 260 G D K+WD+ F GH++ I + F G +GS D+ ++DL + Sbjct: 96 VGYADGVIKVWDLMSKTVLLNFNGHKAAITLLQFDGTGTRLISGSKDSNIIVWDLVGEVG 155 Query: 261 LMTY-SHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLG 319 L SH + I G + + L++ D +WD H L Sbjct: 156 LYKLRSHKDSITGF----WCQGEDWLISTSKDGMIKLWDLKTHQCIETHIAHTGECWGLA 211 Query: 320 VTDDGMAVATGSWDSFLKIWN 340 V DD + T DS +KIW Sbjct: 212 VKDD--LLITTGTDSQVKIWK 230 Score = 115 bits (288), Expect = 2e-26, Method: Composition-based stats. Identities = 66/387 (17%), Positives = 123/387 (31%), Gaps = 69/387 (17%) Query: 16 NQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHL-AKIYAMHWGTDSRLLVSAS 74 Q+ + + + + + + RG A+ + D+ LL Sbjct: 39 GQLITSALEDVNIWDIKTGDLVSKLSDGLPPGASDARGAKPAECTYLEAHKDTDLLAVGY 98 Query: 75 QDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVR 134 DG + +WD + + + + + +G + G D+ +++L G + Sbjct: 99 ADGVIKVWDLMSKTVLLNFNGHKAAITLLQFDGTGTRLISGSKDSNIIVWDLVGEVGLYK 158 Query: 135 VSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAP 194 L H ++ ++ ++++S D LWD++T Q T HTG+ L++ Sbjct: 159 ----LRSHKDSITGFWCQGEDWLISTSKDGMIKLWDLKTHQCIETHIAHTGECWGLAVKD 214 Query: 195 DTRLFVSGACDASAKLW--DVREGMCRQTF-------TGHESDINAICFFPNG----NAF 241 D L ++ D+ K+W D+ + I F N + F Sbjct: 215 D--LLITTGTDSQVKIWKLDIENDKMGGKLTEMGIFEKQSKQRGLKIEFITNSSDKTSFF 272 Query: 242 ATGSDDATCRLFDLRADQE----------------------------------LMTYSHD 267 + D T F +R ++E L + Sbjct: 273 YIQNADKTIETFRIRKEEEIARGLKKREKRLKEKGLTEEEIAKSIKESYSSFILHPFQTI 332 Query: 268 NIICGITSVSF---SKSGRLLLAGYDDFNCNVW-------DALKADRAGV----LAGHDN 313 + I S S+ S S L+ + D L G Sbjct: 333 RSLYKIKSASWTTVSSSKLELVLTTSSNTIEYYSIPYEKRDPTSPAPLKTHTIELQGQRT 392 Query: 314 RVSCLGVTDDGMAVATGSWDSFLKIWN 340 V + ++DD +AT S LKIWN Sbjct: 393 DVRSIDISDDNKLLATASN-GSLKIWN 418 Score = 111 bits (278), Expect = 4e-25, Method: Composition-based stats. Identities = 58/433 (13%), Positives = 119/433 (27%), Gaps = 111/433 (25%) Query: 11 AEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLL 70 A+ + +A K + I + GH A I + + L Sbjct: 77 AKPAECTYLEAHKDTDLLAVGYADGVIKVWDLMSKTVLLNFNGHKAAITLLQFDGTGTRL 136 Query: 71 VSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTRE 130 +S S+D +I+WD ++ + + + +++ D + +++LKT + Sbjct: 137 ISGSKDSNIIVWDLVGEVGLYKLRSHKDSITGF-WCQGEDWLISTSKDGMIKLWDLKTHQ 195 Query: 131 GNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALW--DIETGQ------QTTTFTG 182 HTG DD ++T+ D+ +W DIE + + F Sbjct: 196 ----CIETHIAHTGECWGLAVKDD-LLITTGTDSQVKIWKLDIENDKMGGKLTEMGIFEK 250 Query: 183 HTGDVMSLSL------APDTRLFVSGACDASAKLWDVREGMCRQ---------------- 220 + L + + T F D + + + +R+ Sbjct: 251 QSKQ-RGLKIEFITNSSDKTSFFYIQNADKTIETFRIRKEEEIARGLKKREKRLKEKGLT 309 Query: 221 -------------TFTGH-------ESDINAICF---FPNGNAFATGSDDATCRLFDLRA 257 +F H I + + + + T + + Sbjct: 310 EEEIAKSIKESYSSFILHPFQTIRSLYKIKSASWTTVSSSKLELVLTTSSNTIEYYSIPY 369 Query: 258 DQ---------ELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVL 308 ++ + T + S+ S +LL + + +W+ Sbjct: 370 EKRDPTSPAPLKTHTIELQGQRTDVRSIDISDDNKLLATAS-NGSLKIWNIKTHKCIRTF 428 Query: 309 -----------------------------------------AGHDNRVSCLGVTDDGMAV 327 HD + L +T DG + Sbjct: 429 ECGYALTCKFLPGGLLVILGTRNGELQLFDLASSSLLDTIEDAHDAAIWSLDLTSDGKRL 488 Query: 328 ATGSWDSFLKIWN 340 TGS D +K W+ Sbjct: 489 VTGSADKTVKFWD 501 Score = 89.4 bits (220), Expect = 2e-18, Method: Composition-based stats. Identities = 22/139 (15%), Positives = 54/139 (38%), Gaps = 5/139 (3%) Query: 33 ITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHA 92 + N + M+ +L GH + ++ DS++++++S D + IW + + Sbjct: 551 LDNTVKVFFLDSMKFYLSLYGHKLPVLSIDISFDSKMIITSSADKNIKIWGLDFGDCHKS 610 Query: 93 IPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRF- 151 + +M + P + D + ++ + E ++ H + Sbjct: 611 LFAHQDSIMNVKFLPQSHNFFSCSKDAVVKYWDGEKFECIQKLY----AHQSEVWALAVA 666 Query: 152 LDDNQIVTSSGDTTCALWD 170 D +V+SS D + +W+ Sbjct: 667 TDGGFVVSSSHDHSIRIWE 685 Score = 45.4 bits (106), Expect = 3e-05, Method: Composition-based stats. Identities = 11/38 (28%), Positives = 20/38 (52%) Query: 51 LRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTN 88 L H ++++A+ TD +VS+S D + IW+ Sbjct: 653 LYAHQSEVWALAVATDGGFVVSSSHDHSIRIWEETEDQ 690 >6ID0-T nrPDB Length = 514 Score = 191 bits (486), Expect = 3e-49, Method: Composition-based stats. Identities = 62/315 (19%), Positives = 119/315 (37%), Gaps = 17/315 (5%) Query: 34 TNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAI 93 P + R + GHL + + ++ V+ S D + IWD + ++ Sbjct: 183 PTMPKPQWHPPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSL 242 Query: 94 PLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLD 153 S V + Y+ G D ++L+ +V R GH + Sbjct: 243 TGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYN----KVIRHYHGHLSAVYGLDLHP 298 Query: 154 D-NQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWD 212 + +VT S D+T +WD+ T T +GHT V ++ ++G+ D + +LWD Sbjct: 299 TIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWD 358 Query: 213 VREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICG 272 + G R T T H+ + A+ P FA+GS D + + + S Sbjct: 359 LVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDN-IKQWKFPDGSFIQNLS--GHNAI 415 Query: 273 ITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGH--------DNRVSCLGVTDDG 324 I +++ + G +L++G D+ ++WD + ++ + Sbjct: 416 INTLTVNSDG-VLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSE 474 Query: 325 MAVATGSWDSFLKIW 339 + T D +K++ Sbjct: 475 SRLLTAEADKTIKVY 489 Score = 189 bits (480), Expect = 1e-48, Method: Composition-based stats. Identities = 51/209 (24%), Positives = 89/209 (42%), Gaps = 4/209 (1%) Query: 133 VRVSRELAGHTGYLSCCRFLDDNQ-IVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLS 191 ++ R ++GH G++ C NQ VT S D T +WD+ +G+ + TGH V + Sbjct: 194 WKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVI 253 Query: 192 LAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCR 251 ++ + S D K WD+ + + GH S + + P + T S D+T R Sbjct: 254 VSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTAR 313 Query: 252 LFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGH 311 ++D+R + T S + +V + ++ G D +WD + L H Sbjct: 314 IWDVRTKASVHTLS--GHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNH 371 Query: 312 DNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 V + + A+GS D+ +K W Sbjct: 372 KKSVRAVVLHPRHYTFASGSPDN-IKQWK 399 Score = 99.8 bits (247), Expect = 1e-21, Method: Composition-based stats. Identities = 36/234 (15%), Positives = 74/234 (31%), Gaps = 47/234 (20%) Query: 34 TNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAI 93 + + R GHL+ +Y + +LV+ S+D IWD T VH + Sbjct: 267 DKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTL 326 Query: 94 PLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTRE----------------------- 130 ++ V T + + G D +++L + Sbjct: 327 SGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYT 386 Query: 131 --------------GNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQ- 175 + + L+GH ++ D +V+ + + T LWD TG Sbjct: 387 FASGSPDNIKQWKFPDGSFIQNLSGHNAIINTLTVNSDGVLVSGADNGTMHLWDWRTGYN 446 Query: 176 --------QTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQT 221 Q + +G + + + ++ D + K++ + +T Sbjct: 447 FQRVHAAVQPGSLDSESG-IFACAFDQSESRLLTAEADKTIKVYREDDTATEET 499 >4LG8-A nrPDB Length = 354 Score = 190 bits (482), Expect = 9e-49, Method: Composition-based stats. Identities = 69/338 (20%), Positives = 131/338 (38%), Gaps = 15/338 (4%) Query: 10 EAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLA---KIYAMHWGT- 65 + Q K + + T+ + + + + + H A I A+ Sbjct: 24 QKLQDKATVLTTERKERGKTVPEELVKPEELSKYRQVASHV-GLHSASIPGILALDLCPS 82 Query: 66 DSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYN 125 D+ +++ D ++++D + + + + V + + PS + V D I++ Sbjct: 83 DTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWS 142 Query: 126 LKTREGNVRVSRELAGHTGYLSCCRFL-DDNQIVTSSGDTTCALWDIETGQQTTTFTGHT 184 + N + + H ++ + +++SS D A DI+TG+ T T T Sbjct: 143 V----PNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDET 198 Query: 185 GDV--MSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFA 242 PD +F +G D+ K+WD++E F GH I +I F NG A Sbjct: 199 SGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLA 258 Query: 243 TGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKA 302 T +DD++ +L+DLR + T DN + S+ F +SG L G D + + Sbjct: 259 TAADDSSVKLWDLRKLKNFKTLQLDN-NFEVKSLIFDQSGTYLALGGTDVQIYI--CKQW 315 Query: 303 DRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 H + + +A+ D LK ++ Sbjct: 316 TEILHFTEHSGLTTGVAFGHHAKFIASTGMDRSLKFYS 353 Score = 137 bits (345), Expect = 7e-33, Method: Composition-based stats. Identities = 53/264 (20%), Positives = 101/264 (38%), Gaps = 44/264 (16%) Query: 34 TNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAI 93 N+ + + TL+GH K+ ++ + L+ SAS D + IW + V + Sbjct: 93 DKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVV 152 Query: 94 PLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLD 153 S V + +G+Y+ D + +++T +V+ E +G + L+C +F Sbjct: 153 RAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCS--LTCAQFHP 210 Query: 154 DNQIV-TSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWD 212 D I T + D+ +WD++ F GH+G + S++ + + + A D+S KLWD Sbjct: 211 DGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWD 270 Query: 213 VREGMCRQT-----------------------------------------FTGHESDINA 231 +R+ +T FT H Sbjct: 271 LRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQIYICKQWTEILHFTEHSGLTTG 330 Query: 232 ICFFPNGNAFATGSDDATCRLFDL 255 + F + A+ D + + + L Sbjct: 331 VAFGHHAKFIASTGMDRSLKFYSL 354 Score = 68.6 bits (166), Expect = 4e-12, Method: Composition-based stats. Identities = 24/141 (17%), Positives = 49/141 (34%), Gaps = 8/141 (5%) Query: 33 ITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHA 92 + + I + GH I ++ + + L +A+ D + +WD Sbjct: 220 MDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKT 279 Query: 93 IPLRSSW-VMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRF 151 + L +++ V + + SG Y+A GG D I H+G + F Sbjct: 280 LQLDNNFEVKSLIFDQSGTYLALGGTDVQIYI------CKQWTEILHFTEHSGLTTGVAF 333 Query: 152 -LDDNQIVTSSGDTTCALWDI 171 I ++ D + + + Sbjct: 334 GHHAKFIASTGMDRSLKFYSL 354 >5A31-R nrPDB Length = 386 Score = 189 bits (479), Expect = 2e-48, Method: Composition-based stats. Identities = 62/286 (21%), Positives = 124/286 (43%), Gaps = 17/286 (5%) Query: 61 MHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNI 120 + W + L V+ + + D+ T + VH + + + ++ +G+++A G + + Sbjct: 98 IDWSSTDVLAVALG--KSIFLTDNNTGDVVHLCDTENEY-TSLSWIGAGSHLAVGQANGL 154 Query: 121 CSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQT-TT 179 IY++ R + R L+GH ++C + +++ + + S D D+ T Sbjct: 155 VEIYDVMKR----KCIRTLSGHIDRVACLSW-NNHVLTSGSRDHRILHRDVRMPDPFFET 209 Query: 180 FTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGN 239 HT +V L SG D +++ TF H++ + A+ + P+ Sbjct: 210 IESHTQEVCGLKWNVADNKLASGGNDNVVHVYEGTSKSPILTFDEHKAAVKAMAWSPHKR 269 Query: 240 -AFATGS--DDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLA--GYDDFNC 294 ATG D +++++ ++ + IC + +SK+ L+ GY +N Sbjct: 270 GVLATGGGTADRRLKIWNVNTSIKMSDIDSGSQICNMV---WSKNTNELVTSHGYSKYNL 326 Query: 295 NVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 +WD D +L GH RV L +++DG V +G+ D L+ W Sbjct: 327 TLWDCNSMDPIAILKGHSFRVLHLTLSNDGTTVVSGAGDETLRYWK 372 Score = 117 bits (292), Expect = 1e-26, Method: Composition-based stats. Identities = 41/239 (17%), Positives = 88/239 (36%), Gaps = 14/239 (5%) Query: 24 ACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWD 83 A + + Q ++ ++ + RTL GH+ ++ + W + +L S S+D +++ D Sbjct: 142 AGSHLAVGQANGLVEIYDVMKRKCIRTLSGHIDRVACLSWN--NHVLTSGSRDHRILHRD 199 Query: 84 SYTTNKVH-AIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGH 142 + I + V + + N +A GG DN+ +Y + H Sbjct: 200 VRMPDPFFETIESHTQEVCGLKWNVADNKLASGGNDNVVHVYE----GTSKSPILTFDEH 255 Query: 143 TGYLSCCRFLDDNQ--IVTSSG--DTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRL 198 + + + + T G D +W++ T + + + ++ + +T Sbjct: 256 KAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDIDS-GSQICNMVWSKNTNE 314 Query: 199 FVSGACDAS--AKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDL 255 V+ + LWD GH + + +G +G+ D T R + L Sbjct: 315 LVTSHGYSKYNLTLWDCNSMDPIAILKGHSFRVLHLTLSNDGTTVVSGAGDETLRYWKL 373 Score = 107 bits (268), Expect = 6e-24, Method: Composition-based stats. Identities = 36/259 (13%), Positives = 84/259 (32%), Gaps = 14/259 (5%) Query: 57 KIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGG 116 + ++ W L +G + I+D + + V ++ + G Sbjct: 133 EYTSLSWIGAGSHLAVGQANGLVEIYDVMKRKCIRTLSGHIDRVACLSWNNH--VLTSGS 190 Query: 117 LDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFL-DDNQIVTSSGDTTCALWDIETGQ 175 D+ +++ + + HT + ++ DN++ + D +++ + Sbjct: 191 RDHRILHRDVRMPDPFFE---TIESHTQEVCGLKWNVADNKLASGGNDNVVHVYEGTSKS 247 Query: 176 QTTTFTGHTGDVMSLSLAPDTR-LFVSGA--CDASAKLWDVREGMCRQTFTGHESDINAI 232 TF H V +++ +P R + +G D K+W+V + N + Sbjct: 248 PILTFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDIDSGSQICNMV 307 Query: 233 CFFPNGNAFAT--GSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYD 290 + N N T G L+D + + + ++ S G +++G Sbjct: 308 -WSKNTNELVTSHGYSKYNLTLWDCNSMDPIAIL--KGHSFRVLHLTLSNDGTTVVSGAG 364 Query: 291 DFNCNVWDALKADRAGVLA 309 D W + Sbjct: 365 DETLRYWKLFDVSVLNLFT 383 Score = 102 bits (255), Expect = 2e-22, Method: Composition-based stats. Identities = 41/187 (21%), Positives = 78/187 (41%), Gaps = 9/187 (4%) Query: 42 RIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVM 101 R+ T+ H ++ + W L S D + +++ + + + + V Sbjct: 201 RMPDPFFETIESHTQEVCGLKWNVADNKLASGGNDNVVHVYEGTSKSPILTFDEHKAAVK 260 Query: 102 TCAYAPSGN-YVACGG--LDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIV 158 A++P +A GG D I+N+ T ++++S +G + + + N++V Sbjct: 261 AMAWSPHKRGVLATGGGTADRRLKIWNVNT---SIKMSDIDSG-SQICNMVWSKNTNELV 316 Query: 159 TSSG--DTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREG 216 TS G LWD + GH+ V+ L+L+ D VSGA D + + W + + Sbjct: 317 TSHGYSKYNLTLWDCNSMDPIAILKGHSFRVLHLTLSNDGTTVVSGAGDETLRYWKLFDV 376 Query: 217 MCRQTFT 223 FT Sbjct: 377 SVLNLFT 383 >5Y88-O nrPDB Length = 451 Score = 188 bits (477), Expect = 3e-48, Method: Composition-based stats. Identities = 67/330 (20%), Positives = 121/330 (36%), Gaps = 19/330 (5%) Query: 21 ARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGT-DSRLLVSASQDGKL 79 A + + ++ + + R + GHL + + D+ ++ S D + Sbjct: 107 AEELIVNRYEKLLSQRPEW--HAPWKLSRVINGHLGWVRCVAIDPVDNEWFITGSNDTTM 164 Query: 80 IIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSREL 139 +WD T + V A + Y+ D ++L+ + + R+ Sbjct: 165 KVWDLATGKLKTTLAGHVMTVRDVAVSDRHPYLFSVSEDKTVKCWDLEKNQ----IIRDY 220 Query: 140 AGHTGYLSCCRFLDD-NQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRL 198 GH + + I T+ D+ LWD+ T T GH G + + P Sbjct: 221 YGHLSGVRTVSIHPTLDLIATAGRDSVIKLWDMRTRIPVITLVGHKGPINQVQCTPVDPQ 280 Query: 199 FVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRAD 258 VS + DA+ +LWDV G + T H+ + A P + A+ D R + L Sbjct: 281 VVSSSTDATVRLWDVVAGKTMKVLTHHKRSVRATALHPKEFSVASACTD-DIRSWGLAEG 339 Query: 259 QELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLA--------G 310 L + + I ++S ++ +L AG D+ + +D + LA Sbjct: 340 SLLTNFESEKTGI-INTLSINQD-DVLFAGGDNGVLSFYDYKSGHKYQSLATREMVGSLE 397 Query: 311 HDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 + V C G+ + TG D +KIW Sbjct: 398 GERSVLCSTFDKTGLRLITGEADKSIKIWK 427 >3FM0-A nrPDB Length = 345 Score = 188 bits (477), Expect = 4e-48, Method: Composition-based stats. Identities = 65/319 (20%), Positives = 115/319 (36%), Gaps = 35/319 (10%) Query: 55 LAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTN---KVHAIPLRSSWVMTCAYAPSGNY 111 ++ + + W LL S D ++ IW + + K V A++P GNY Sbjct: 16 DSRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNY 75 Query: 112 VACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLD-DNQIVTSSGDTTCALWD 170 +A D I+ K + + L GH + + N + T S D + +W+ Sbjct: 76 LASASFDATTCIW--KKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWE 133 Query: 171 IETG---QQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCR--QTFTGH 225 ++ + + HT DV + P L S + D + KL+ E T GH Sbjct: 134 VDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGH 193 Query: 226 ESDINAICFFPNGNAFATGSDDATCRLFDL---RADQELMTYSHDN-----------IIC 271 ES + ++ F P+G A+ SDD T R++ +Q + D Sbjct: 194 ESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSR 253 Query: 272 GITSVSFSKSGRLLLAGYDDFNCNVW--DALKADRAGVLA-------GHDNRVSCLGVTD 322 I +++ + L D V+ D + + H V+C+ Sbjct: 254 TIYDIAWCQLTGALATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNP 313 Query: 323 -DGMAVATGSWDSFLKIWN 340 + +A+ S D + W Sbjct: 314 KEPGLLASCSDDGEVAFWK 332 Score = 162 bits (411), Expect = 2e-40, Method: Composition-based stats. Identities = 54/268 (20%), Positives = 100/268 (37%), Gaps = 23/268 (8%) Query: 95 LRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLD- 153 S A+ P+G +A G D I+ + + GH + + Sbjct: 14 HPDSRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLS-EGHQRTVRKVAWSPC 72 Query: 154 DNQIVTSSGDTTCALW--DIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLW 211 N + ++S D T +W + + + TT GH +V S++ AP L + + D S +W Sbjct: 73 GNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVW 132 Query: 212 DVREG---MCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDN 268 +V E C H D+ + + P+ A+ S D T +L+ D + + + Sbjct: 133 EVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEG 192 Query: 269 IICGITSVSFSKSGRLLLAGYDDFNCNVW---------------DALKADRAGVLAG-HD 312 + S++F SG+ L + DD +W L+G H Sbjct: 193 HESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHS 252 Query: 313 NRVSCLGVTDDGMAVATGSWDSFLKIWN 340 + + A+AT D ++++ Sbjct: 253 RTIYDIAWCQLTGALATACGDDAIRVFQ 280 Score = 156 bits (394), Expect = 2e-38, Method: Composition-based stats. Identities = 62/281 (22%), Positives = 100/281 (35%), Gaps = 30/281 (10%) Query: 52 RGHLAKIYAMHWGTDSRLLVSASQDGKLIIW--DSYTTNKVHAIPLRSSWVMTCAYAPSG 109 GH + + W L SAS D IW + V + + V + A+APSG Sbjct: 58 EGHQRTVRKVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSG 117 Query: 110 NYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIV-TSSGDTTCAL 168 N +A D ++ + E L HT + + +++ ++S D T L Sbjct: 118 NLLATCSRDKSVWVWEVDE-EDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKL 176 Query: 169 WDIETGQ--QTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLW--------------- 211 + E T GH V SL+ P + S + D + ++W Sbjct: 177 YREEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSG 236 Query: 212 DVREGMCRQTFTG-HESDINAICFFPNGNAFATGSDDATCRLF--DLRADQELMTYS--- 265 C T +G H I I + A AT D R+F D +D + T+S Sbjct: 237 SDPSWKCICTLSGFHSRTIYDIAWCQLTGALATACGDDAIRVFQEDPNSDPQQPTFSLTA 296 Query: 266 --HDNIICGITSVSFSKSGR-LLLAGYDDFNCNVWDALKAD 303 H + V+++ LL + DD W + + Sbjct: 297 HLHQAHSQDVNCVAWNPKEPGLLASCSDDGEVAFWKYQRPE 337 Score = 134 bits (337), Expect = 5e-32, Method: Composition-based stats. Identities = 43/243 (17%), Positives = 85/243 (34%), Gaps = 32/243 (13%) Query: 49 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTT---NKVHAIPLRSSWVMTCAY 105 TL GH ++ ++ W LL + S+D + +W+ V + + V + Sbjct: 99 TTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVW 158 Query: 106 APSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDN-QIVTSSGDT 164 PS +A D+ +Y + E + L GH + F ++ + S D Sbjct: 159 HPSQELLASASYDDTVKLY--REEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDR 216 Query: 165 TCALW---------------DIETGQQTTTFTG-HTGDVMSLSLAPDTRLFVSGACDASA 208 T +W + + T +G H+ + ++ T + D + Sbjct: 217 TVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQLTGALATACGDDAI 276 Query: 209 KLW--DVREGMCRQTF-------TGHESDINAICFFP-NGNAFATGSDDATCRLFDLRAD 258 +++ D + TF H D+N + + P A+ SDD + + Sbjct: 277 RVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPKEPGLLASCSDDGEVAFWKYQRP 336 Query: 259 QEL 261 + L Sbjct: 337 EGL 339 Score = 40.8 bits (94), Expect = 7e-04, Method: Composition-based stats. Identities = 14/55 (25%), Positives = 20/55 (36%), Gaps = 1/55 (1%) Query: 32 QITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGT-DSRLLVSASQDGKLIIWDSY 85 Q N DP T + H + + W + LL S S DG++ W Sbjct: 280 QEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPKEPGLLASCSDDGEVAFWKYQ 334 >4BH6-A nrPDB Length = 308 Score = 186 bits (471), Expect = 2e-47, Method: Composition-based stats. Identities = 62/286 (21%), Positives = 124/286 (43%), Gaps = 17/286 (5%) Query: 61 MHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNI 120 + W + L V+ + + D+ T + VH + + + ++ +G+++A G + + Sbjct: 29 IDWSSTDVLAVALG--KSIFLTDNNTGDVVHLCDTENEY-TSLSWIGAGSHLAVGQANGL 85 Query: 121 CSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQT-TT 179 IY++ R + R L+GH ++C + +++ + + S D D+ T Sbjct: 86 VEIYDVMKR----KCIRTLSGHIDRVACLSW-NNHVLTSGSRDHRILHRDVRMPDPFFET 140 Query: 180 FTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGN 239 HT +V L SG D +++ TF H++ + A+ + P+ Sbjct: 141 IESHTQEVCGLKWNVADNKLASGGNDNVVHVYEGTSKSPILTFDEHKAAVKAMAWSPHKR 200 Query: 240 -AFATGS--DDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLA--GYDDFNC 294 ATG D +++++ ++ + IC + +SK+ L+ GY +N Sbjct: 201 GVLATGGGTADRRLKIWNVNTSIKMSDIDSGSQICNMV---WSKNTNELVTSHGYSKYNL 257 Query: 295 NVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 +WD D +L GH RV L +++DG V +G+ D L+ W Sbjct: 258 TLWDCNSMDPIAILKGHSFRVLHLTLSNDGTTVVSGAGDETLRYWK 303 Score = 114 bits (286), Expect = 4e-26, Method: Composition-based stats. Identities = 41/239 (17%), Positives = 88/239 (36%), Gaps = 14/239 (5%) Query: 24 ACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWD 83 A + + Q ++ ++ + RTL GH+ ++ + W + +L S S+D +++ D Sbjct: 73 AGSHLAVGQANGLVEIYDVMKRKCIRTLSGHIDRVACLSWN--NHVLTSGSRDHRILHRD 130 Query: 84 SYTTNKVH-AIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGH 142 + I + V + + N +A GG DN+ +Y + H Sbjct: 131 VRMPDPFFETIESHTQEVCGLKWNVADNKLASGGNDNVVHVYE----GTSKSPILTFDEH 186 Query: 143 TGYLSCCRFLDDNQ--IVTSSG--DTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRL 198 + + + + T G D +W++ T + + + ++ + +T Sbjct: 187 KAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDIDS-GSQICNMVWSKNTNE 245 Query: 199 FVSGACDAS--AKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDL 255 V+ + LWD GH + + +G +G+ D T R + L Sbjct: 246 LVTSHGYSKYNLTLWDCNSMDPIAILKGHSFRVLHLTLSNDGTTVVSGAGDETLRYWKL 304 Score = 105 bits (261), Expect = 4e-23, Method: Composition-based stats. Identities = 36/247 (14%), Positives = 83/247 (33%), Gaps = 14/247 (5%) Query: 57 KIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGG 116 + ++ W L +G + I+D + + V ++ + G Sbjct: 64 EYTSLSWIGAGSHLAVGQANGLVEIYDVMKRKCIRTLSGHIDRVACLSWNNH--VLTSGS 121 Query: 117 LDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFL-DDNQIVTSSGDTTCALWDIETGQ 175 D+ +++ + + HT + ++ DN++ + D +++ + Sbjct: 122 RDHRILHRDVRMPDPFFE---TIESHTQEVCGLKWNVADNKLASGGNDNVVHVYEGTSKS 178 Query: 176 QTTTFTGHTGDVMSLSLAPDTR-LFVSGA--CDASAKLWDVREGMCRQTFTGHESDINAI 232 TF H V +++ +P R + +G D K+W+V + N + Sbjct: 179 PILTFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDIDSGSQICNMV 238 Query: 233 CFFPNGNAFAT--GSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYD 290 + N N T G L+D + + + ++ S G +++G Sbjct: 239 -WSKNTNELVTSHGYSKYNLTLWDCNSMDPIAIL--KGHSFRVLHLTLSNDGTTVVSGAG 295 Query: 291 DFNCNVW 297 D W Sbjct: 296 DETLRYW 302 Score = 34.3 bits (77), Expect = 0.085, Method: Composition-based stats. Identities = 11/50 (22%), Positives = 19/50 (38%) Query: 36 NIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSY 85 N+ M L+GH ++ + D +VS + D L W + Sbjct: 256 NLTLWDCNSMDPIAILKGHSFRVLHLTLSNDGTTVVSGAGDETLRYWKLF 305 >5WYJ-BC nrPDB Length = 817 Score = 185 bits (469), Expect = 3e-47, Method: Composition-based stats. Identities = 49/264 (18%), Positives = 100/264 (37%), Gaps = 18/264 (6%) Query: 93 IPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFL 152 + + G ++A DN ++ + + GH+ ++ Sbjct: 384 YEGHEDLLNSLDATEDGLWIATASKDNTAIVWRYNENSCKFDIYAKYIGHSAAVTAVGLP 443 Query: 153 D------DNQIVTSSGDTTCALW---------DIETGQQT-TTFTGHTGDVMSLSLAPDT 196 + ++T+S D T W D++ + + T H D+ +LS++P+ Sbjct: 444 NIVSKGYPEFLLTASNDLTIKKWIIPKPTASMDVQIIKVSEYTRHAHEKDINALSVSPND 503 Query: 197 RLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLR 256 +F + + D + K+W++ G T H+ + + F AT S D T +++ L Sbjct: 504 SIFATASYDKTCKIWNLENGELEATLANHKRGLWDVSFCQYDKLLATSSGDKTVKIWSLD 563 Query: 257 ADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVS 316 + T + + SF + L++ D +WD + L GH+NR+ Sbjct: 564 TFSVMKTL--EGHTNAVQRCSFINKQKQLISCGADGLIKIWDCSSGECLKTLDGHNNRLW 621 Query: 317 CLGVTDDGMAVATGSWDSFLKIWN 340 L +DG + + D + W Sbjct: 622 ALSTMNDGDMIVSADADGVFQFWK 645 Score = 170 bits (431), Expect = 7e-43, Method: Composition-based stats. Identities = 44/289 (15%), Positives = 97/289 (33%), Gaps = 19/289 (6%) Query: 25 CADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDS 84 + + + P + + GH + ++ D + +AS+D I+W Sbjct: 359 SPSLRIIPVPDLSGPEASLPLDVE-IYEGHEDLLNSLDATEDGLWIATASKDNTAIVWRY 417 Query: 85 YTTNKVHAIP----LRSSWVMTCAYAP-----SGNYVACGGLDNICSIYNLKTREGNVRV 135 + I S+ V ++ D + + ++ V Sbjct: 418 NENSCKFDIYAKYIGHSAAVTAVGLPNIVSKGYPEFLLTASNDLTIKKWIIPKPTASMDV 477 Query: 136 ------SRELAGHTGYLSCCRFLDDNQI-VTSSGDTTCALWDIETGQQTTTFTGHTGDVM 188 H ++ ++ I T+S D TC +W++E G+ T H + Sbjct: 478 QIIKVSEYTRHAHEKDINALSVSPNDSIFATASYDKTCKIWNLENGELEATLANHKRGLW 537 Query: 189 SLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDA 248 +S +L + + D + K+W + +T GH + + F + D Sbjct: 538 DVSFCQYDKLLATSSGDKTVKIWSLDTFSVMKTLEGHTNAVQRCSFINKQKQLISCGADG 597 Query: 249 TCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVW 297 +++D + + L T D + ++S G ++++ D W Sbjct: 598 LIKIWDCSSGECLKTL--DGHNNRLWALSTMNDGDMIVSADADGVFQFW 644 Score = 157 bits (397), Expect = 7e-39, Method: Composition-based stats. Identities = 57/274 (20%), Positives = 98/274 (35%), Gaps = 31/274 (11%) Query: 53 GHLAKIYAMHWGTD-----SRLLVSASQDGKLIIWDSYTTN----------KVHAIPLRS 97 GH A + A+ L++AS D + W + Sbjct: 432 GHSAAVTAVGLPNIVSKGYPEFLLTASNDLTIKKWIIPKPTASMDVQIIKVSEYTRHAHE 491 Query: 98 SWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLD-DNQ 156 + + +P+ + A D C I+NL+ E + LA H L F D Sbjct: 492 KDINALSVSPNDSIFATASYDKTCKIWNLENGE----LEATLANHKRGLWDVSFCQYDKL 547 Query: 157 IVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREG 216 + TSSGD T +W ++T T GHT V S + +S D K+WD G Sbjct: 548 LATSSGDKTVKIWSLDTFSVMKTLEGHTNAVQRCSFINKQKQLISCGADGLIKIWDCSSG 607 Query: 217 MCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRA---------DQELMTYSHD 267 C +T GH + + A+ +G+ + D + + +L Sbjct: 608 ECLKTLDGHNNRLWALSTMNDGDMIVSADADGVFQFWKDCTEQEIEEEQEKAKLQVEQEQ 667 Query: 268 NIICGITSVSFSKSGRLLLAGYDDFNCNVWDALK 301 ++ ++ ++ + LLA D +++ LK Sbjct: 668 SLQNYMSKGDWTNA--FLLAMTLDHPMRLFNVLK 699 Score = 117 bits (292), Expect = 9e-27, Method: Composition-based stats. Identities = 69/417 (16%), Positives = 124/417 (29%), Gaps = 94/417 (22%) Query: 16 NQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHW----GTDSRLLV 71 + I DA + +I V + +GH I ++ + + LL Sbjct: 105 SYILDADSTSTLLAVGGTDGSIIVVDIENGYITHSFKGHGGTISSLKFYGQLNSKIWLLA 164 Query: 72 SASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYA--PSGNY----VACGGLDNICSIYN 125 S +G + +WD +H + +S V P + + GG D+I ++++ Sbjct: 165 SGDTNGMVKVWDLVKRKCLHTLQEHTSAVRGLDIIEVPDNDEPSLNLLSGGRDDIINLWD 224 Query: 126 LKTREGNVRVSRELAGHTGYLSCCRFLDDNQ----IVTSSGDTTCALWDIETG------- 174 ++ + + C FL D I T+ GD L D E+G Sbjct: 225 FNMKKKCKLLKTLPV--NQQVESCGFLKDGDGKRIIYTAGGDAIFQLIDSESGSVLKRTN 282 Query: 175 ---------------------------------------------QQTTTFTGHTGDVMS 189 Q T++ G+ G + Sbjct: 283 KPIEELFIIGVLPILSNSQMFLVLSDQTLQLINVEEDLKNDEDTIQVTSSIAGNHGIIAD 342 Query: 190 LSLA-PDTRLFVSGACDASAKLW---DVREGMC-----RQTFTGHESDINAICFFPNGNA 240 + P+ S ++ D+ + + GHE +N++ +G Sbjct: 343 MRYVGPELNKLALATNSPSLRIIPVPDLSGPEASLPLDVEIYEGHEDLLNSLDATEDGLW 402 Query: 241 FATGSDDATCRLFDLRADQELMTYSHD--NIICGITSVSFSK-----SGRLLLAGYDDFN 293 AT S D T ++ + +T+V LL +D Sbjct: 403 IATASKDNTAIVWRYNENSCKFDIYAKYIGHSAAVTAVGLPNIVSKGYPEFLLTASNDLT 462 Query: 294 CNVWDALKAD----------RAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 W K H+ ++ L V+ + AT S+D KIWN Sbjct: 463 IKKWIIPKPTASMDVQIIKVSEYTRHAHEKDINALSVSPNDSIFATASYDKTCKIWN 519 Score = 102 bits (254), Expect = 2e-22, Method: Composition-based stats. Identities = 49/260 (18%), Positives = 87/260 (33%), Gaps = 21/260 (8%) Query: 64 GTDSRLLVSASQDGKLIIWDSYTT--NKVHAIPLRS-SWVMTCAYAPSGNYVACGGLDNI 120 + ++L + D ++ I D +H I + P G Y+ + Sbjct: 26 SENGKILATPVLD-EINIIDLTPGSRKILHKISNEDEQEITALKLTPDGQYLTYVSQAQL 84 Query: 121 CSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTF 180 I++LKT +V R + + + D + + DIE G T +F Sbjct: 85 LKIFHLKTG----KVVRSMKISSPSYILDADSTSTLLAVGGTDGSIIVVDIENGYITHSF 140 Query: 181 TGHTGDVMSLSLAPDTR----LFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFF- 235 GH G + SL L SG + K+WD+ + C T H S + + Sbjct: 141 KGHGGTISSLKFYGQLNSKIWLLASGDTNGMVKVWDLVKRKCLHTLQEHTSAVRGLDIIE 200 Query: 236 -PNGNA----FATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSG---RLLLA 287 P+ + +G D L+D ++ + + S F K G R++ Sbjct: 201 VPDNDEPSLNLLSGGRDDIINLWDFNMKKKCKLLKTLPVNQQVESCGFLKDGDGKRIIYT 260 Query: 288 GYDDFNCNVWDALKADRAGV 307 D + D+ Sbjct: 261 AGGDAIFQLIDSESGSVLKR 280 Score = 101 bits (252), Expect = 4e-22, Method: Composition-based stats. Identities = 73/397 (18%), Positives = 128/397 (32%), Gaps = 81/397 (20%) Query: 18 IRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDG 77 + + K A L +I N ID + + +I A+ D + L SQ Sbjct: 25 VSENGKILATPVLDEI-NIIDLTPGSRKILHKISNEDEQEITALKLTPDGQYLTYVSQAQ 83 Query: 78 KLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSR 137 L I+ T V ++ + SS + +A GG D + +++ ++ Sbjct: 84 LLKIFHLKTGKVVRSMKI-SSPSYILDADSTSTLLAVGGTDGSIIVVDIENGY----ITH 138 Query: 138 ELAGHTGYLSCCRF---LDDNQIVTSSGDTT--CALWDIETGQQTTTFTGHTGDVMSLSL 192 GH G +S +F L+ + +SGDT +WD+ + T HT V L + Sbjct: 139 SFKGHGGTISSLKFYGQLNSKIWLLASGDTNGMVKVWDLVKRKCLHTLQEHTSAVRGLDI 198 Query: 193 --APDTR----LFVSGACDASAKLWD--VREGMCRQTFTGHESDINAICFFPNGN---AF 241 PD +SG D LWD +++ + + F +G+ Sbjct: 199 IEVPDNDEPSLNLLSGGRDDIINLWDFNMKKKCKLLKTLPVNQQVESCGFLKDGDGKRII 258 Query: 242 ATGSDDATCRLFDLRADQELMT-------------------------------------- 263 T DA +L D + L Sbjct: 259 YTAGGDAIFQLIDSESGSVLKRTNKPIEELFIIGVLPILSNSQMFLVLSDQTLQLINVEE 318 Query: 264 -YSHDNIICGITSVSFSKSG------------RLLLAGYDDFNCNVW--------DALKA 302 +D +TS G L + + + +A Sbjct: 319 DLKNDEDTIQVTSSIAGNHGIIADMRYVGPELNKLALATNSPSLRIIPVPDLSGPEASLP 378 Query: 303 DRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIW 339 + GH++ ++ L T+DG+ +AT S D+ +W Sbjct: 379 LDVEIYEGHEDLLNSLDATEDGLWIATASKDNTAIVW 415 Score = 94.4 bits (233), Expect = 7e-20, Method: Composition-based stats. Identities = 29/176 (16%), Positives = 61/176 (34%), Gaps = 15/176 (8%) Query: 5 DQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQM----------RTRRTLRGH 54 + + ++ R A + +A ++I TL H Sbjct: 473 ASMDVQIIKVSEYTRHAHEKDINALSVSPNDSIFATASYDKTCKIWNLENGELEATLANH 532 Query: 55 LAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVAC 114 ++ + + +LL ++S D + IW T + + + ++ V C++ + Sbjct: 533 KRGLWDVSFCQYDKLLATSSGDKTVKIWSLDTFSVMKTLEGHTNAVQRCSFINKQKQLIS 592 Query: 115 GGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCR-FLDDNQIVTSSGDTTCALW 169 G D + I++ + E + L GH L D + IV++ D W Sbjct: 593 CGADGLIKIWDCSSGE----CLKTLDGHNNRLWALSTMNDGDMIVSADADGVFQFW 644 Score = 62.0 bits (149), Expect = 3e-10, Method: Composition-based stats. Identities = 23/119 (19%), Positives = 42/119 (35%), Gaps = 7/119 (5%) Query: 226 ESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLL 285 E +I A+ P+G S ++F L+ + + + I + + LL Sbjct: 61 EQEITALKLTPDGQYLTYVSQAQLLKIFHLKTGKVVRSM---KISSPSYILDADSTSTLL 117 Query: 286 LAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGV----TDDGMAVATGSWDSFLKIWN 340 G D + V D GH +S L +A+G + +K+W+ Sbjct: 118 AVGGTDGSIIVVDIENGYITHSFKGHGGTISSLKFYGQLNSKIWLLASGDTNGMVKVWD 176 >4BTS-AR nrPDB Length = 343 Score = 177 bits (450), Expect = 4e-45, Method: Composition-based stats. Identities = 65/338 (19%), Positives = 122/338 (36%), Gaps = 49/338 (14%) Query: 43 IQMRTRRTLRGHLAKIYAM------HWGTDSRLLVSASQDGKLIIWDSYTTN-------K 89 IQ+ R L GH + ++ DS +L+S S+D ++IW Y Sbjct: 9 IQVVKRGILEGHSDWVTSIVAGFSQKENEDSPVLISGSRDKTVMIWKLYEEEQNGYFGIP 68 Query: 90 VHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCC 149 A+ + +V A + + D +++L+T + GH + Sbjct: 69 HKALTGHNHFVSDLALSQENCFAISSSWDKTLRLWDLRTGT----TYKRFVGHQSEVYSV 124 Query: 150 RFLDDNQ-IVTSSGDTTCALWDIETGQQT---TTFTGHTGDVMSLSLA----------PD 195 F DN+ I+++ + LW+I G+ H+ V + + P Sbjct: 125 AFSPDNRQILSAGAEREIKLWNIL-GECKFSSAEKENHSDWVSCVRYSPIMKSANKVQPF 183 Query: 196 TRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDL 255 F S D K+W+ R TF HES++N + PNG ATG D ++D+ Sbjct: 184 APYFASVGWDGRLKVWN-TNFQIRYTFKAHESNVNHLSISPNGKYIATGGKDKKLLIWDI 242 Query: 256 RADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVL------- 308 + I ++F+ + + G D +++ + +A V Sbjct: 243 LNLT--YPQREFDAGSTINQIAFNPKLQWVAVGTDQG-VKIFNLMTQSKAPVCTIEAEPI 299 Query: 309 ------AGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 G + + + L G + G D ++ ++ Sbjct: 300 TKAEGQKGKNPQCTSLAWNALGKKLFAGFTDGVIRTFS 337 Score = 174 bits (442), Expect = 4e-44, Method: Composition-based stats. Identities = 58/280 (20%), Positives = 106/280 (37%), Gaps = 28/280 (10%) Query: 48 RRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAP 107 + L GH + + ++ +S+S D L +WD T S V + A++P Sbjct: 69 HKALTGHNHFVSDLALSQENCFAISSSWDKTLRLWDLRTGTTYKRFVGHQSEVYSVAFSP 128 Query: 108 SGNYVACGGLDNICSIYNLKTREGNVRV-SRELAGHTGYLSCCRFLD-----------DN 155 + G + ++N+ G + S E H+ ++SC R+ Sbjct: 129 DNRQILSAGAEREIKLWNI---LGECKFSSAEKENHSDWVSCVRYSPIMKSANKVQPFAP 185 Query: 156 QIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVRE 215 + D +W+ Q TF H +V LS++P+ + +G D +WD+ Sbjct: 186 YFASVGWDGRLKVWNT-NFQIRYTFKAHESNVNHLSISPNGKYIATGGKDKKLLIWDILN 244 Query: 216 GMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDL--RADQELMTYSHDNII--- 270 Q S IN I F P A G+ D ++F+L ++ + T + I Sbjct: 245 LTYPQREFDAGSTINQIAFNPKLQWVAVGT-DQGVKIFNLMTQSKAPVCTIEAEPITKAE 303 Query: 271 ------CGITSVSFSKSGRLLLAGYDDFNCNVWDALKADR 304 TS++++ G+ L AG+ D + + Sbjct: 304 GQKGKNPQCTSLAWNALGKKLFAGFTDGVIRTFSFETSAN 343 Score = 108 bits (269), Expect = 4e-24, Method: Composition-based stats. Identities = 39/246 (15%), Positives = 77/246 (31%), Gaps = 32/246 (13%) Query: 40 VGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAI--PLRS 97 T + GH +++Y++ + D+R ++SA + ++ +W+ K + S Sbjct: 103 WDLRTGTTYKRFVGHQSEVYSVAFSPDNRQILSAGAEREIKLWNILGECKFSSAEKENHS 162 Query: 98 SWVMTCAYAPS----------GNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLS 147 WV Y+P Y A G D ++N N ++ H ++ Sbjct: 163 DWVSCVRYSPIMKSANKVQPFAPYFASVGWDGRLKVWNT-----NFQIRYTFKAHESNVN 217 Query: 148 CCRFLDDNQ-IVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDA 206 + + I T D +WDI + ++ P + G D Sbjct: 218 HLSISPNGKYIATGGKDKKLLIWDILNLTYPQREFDAGSTINQIAFNPKLQWVAVGT-DQ 276 Query: 207 SAKLWDV--REGMCRQTFT-----------GHESDINAICFFPNGNAFATGSDDATCRLF 253 K++++ + T G ++ + G G D R F Sbjct: 277 GVKIFNLMTQSKAPVCTIEAEPITKAEGQKGKNPQCTSLAWNALGKKLFAGFTDGVIRTF 336 Query: 254 DLRADQ 259 Sbjct: 337 SFETSA 342 >5FVM-C nrPDB Length = 303 Score = 177 bits (449), Expect = 6e-45, Method: Composition-based stats. Identities = 55/238 (23%), Positives = 103/238 (43%), Gaps = 14/238 (5%) Query: 111 YVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWD 170 +A G D+ + T SR + ++ D + + ++G L+D Sbjct: 4 ILASAGYDHTIRFWEALTGV----CSRTIQHADSQVNRLEITSDKKYLAAAGHLHVRLYD 59 Query: 171 IE--TGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESD 228 I ++F GH G+V S++ + R VS + D + K+WDVR ++ + H + Sbjct: 60 IRSNNPNPVSSFEGHKGNVTSIAFQQENRWMVSSSEDGTIKVWDVRSPSVQRNYK-HNAP 118 Query: 229 INAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAG 288 +N + PN + D R++DL +Q + ++ + S+S + G +L+AG Sbjct: 119 VNEVAIHPNQGELISCDQDGNIRIWDLGENQCTNQLTPED-NTPLQSLSVASDGSMLVAG 177 Query: 289 YDDFNCNVW------DALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 + NC VW DA + H ++ + ++ D +AT S D ++WN Sbjct: 178 NNKGNCYVWRMPHHTDASTLEPVTKFKSHTKYITRVLLSADVKNLATCSADHTARVWN 235 Score = 172 bits (435), Expect = 2e-43, Method: Composition-based stats. Identities = 57/281 (20%), Positives = 109/281 (38%), Gaps = 11/281 (3%) Query: 67 SRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNL 126 S +L SA D + W++ T I S V Y+A G +Y++ Sbjct: 2 SVILASAGYDHTIRFWEALTGVCSRTIQHADSQVNRLEITSDKKYLAAAGH-LHVRLYDI 60 Query: 127 KTREGNVRVSRELAGHTGYLSCCRFLDDNQ-IVTSSGDTTCALWDIETGQQTTTFTGHTG 185 ++ N GH G ++ F +N+ +V+SS D T +WD+ + + H Sbjct: 61 RSNNPN--PVSSFEGHKGNVTSIAFQQENRWMVSSSEDGTIKVWDVRSPSVQRNYK-HNA 117 Query: 186 DVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHES-DINAICFFPNGNAFATG 244 V +++ P+ +S D + ++WD+ E C T ++ + ++ +G+ G Sbjct: 118 PVNEVAIHPNQGELISCDQDGNIRIWDLGENQCTNQLTPEDNTPLQSLSVASDGSMLVAG 177 Query: 245 SDDATCRLFDLRADQELMTYS----HDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDAL 300 ++ C ++ + + T + IT V S + L D VW+ Sbjct: 178 NNKGNCYVWRMPHHTDASTLEPVTKFKSHTKYITRVLLSADVKNLATCSADHTARVWNIE 237 Query: 301 -KADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 L GH V + D + T D ++++W+ Sbjct: 238 DNYQLETTLDGHQRWVWDCAFSADSAYLVTACSDHYVRLWD 278 Score = 147 bits (372), Expect = 5e-36, Method: Composition-based stats. Identities = 50/276 (18%), Positives = 105/276 (38%), Gaps = 12/276 (4%) Query: 5 DQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWG 64 + Q A+ N++ A + + + + GH + ++ + Sbjct: 25 SRTIQHADSQVNRLEITSDKKYLAAAGHLHVRLYDIRSNNPNPVSSFEGHKGNVTSIAFQ 84 Query: 65 TDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIY 124 ++R +VS+S+DG + +WD + + ++ V A P+ + D I+ Sbjct: 85 QENRWMVSSSEDGTIKVWDVRSPSVQRNYK-HNAPVNEVAIHPNQGELISCDQDGNIRIW 143 Query: 125 NLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALW------DIETGQQTT 178 +L + ++ +T S D + +V + C +W D T + T Sbjct: 144 DLGENQCTNQL--TPEDNTPLQSLSVASDGSMLVAGNNKGNCYVWRMPHHTDASTLEPVT 201 Query: 179 TFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREG-MCRQTFTGHESDINAICFFPN 237 F HT + + L+ D + + + D +A++W++ + T GH+ + F + Sbjct: 202 KFKSHTKYITRVLLSADVKNLATCSADHTARVWNIEDNYQLETTLDGHQRWVWDCAFSAD 261 Query: 238 GNAFATGSDDATCRLFDLRADQELMTYS--HDNIIC 271 T D RL+DL + + Y H +C Sbjct: 262 SAYLVTACSDHYVRLWDLSTSEIVRQYGGHHKGAVC 297 Score = 57.0 bits (136), Expect = 1e-08, Method: Composition-based stats. Identities = 15/61 (24%), Positives = 24/61 (39%) Query: 44 QMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTC 103 + TL GH ++ + DS LV+A D + +WD T+ V + Sbjct: 239 NYQLETTLDGHQRWVWDCAFSADSAYLVTACSDHYVRLWDLSTSEIVRQYGGHHKGAVCV 298 Query: 104 A 104 A Sbjct: 299 A 299 >3JB9-g nrPDB Length = 558 Score = 176 bits (446), Expect = 1e-44, Method: Composition-based stats. Identities = 62/306 (20%), Positives = 103/306 (33%), Gaps = 57/306 (18%) Query: 88 NKVHAIPLRSSWVMTCAYAP-SGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYL 146 + + + + P SG+ + G +DN I+ + + + R GH + Sbjct: 257 KHIFTWKGHTKGISCLRFFPISGHLLLSGSMDNQIKIWEVYH---DRSLLRTFQGHARPI 313 Query: 147 SCCRFLDDNQ-IVTSSGDTTCALWDIETGQQTTTFTGHT-GDVMSLSLAPD-TRLFVSGA 203 F D + +++S D T LWD E G+ F + + + PD F++G Sbjct: 314 RDLSFSQDGRSFLSTSFDKTIKLWDTELGKCLNCFNSDRLTNCVKFQVDPDKPNEFLAGT 373 Query: 204 CDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMT 263 D +D+R Q + H IN+I F NG F T SDD++ R ++ + Sbjct: 374 ADKRILQFDIRSPDIVQAYDHHLGGINSITFLENGKRFVTTSDDSSMRFWEYGTPVPI-K 432 Query: 264 YSHDNIICGITSVS---------------------------------------------- 277 + D + + V+ Sbjct: 433 FVADIAMHSMPRVALRPNGKSIACQSLDNCIYVYSAYEKYRQNKKKVFKGYSCSGYSLEV 492 Query: 278 -FSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTD-DGMAVATGS-WDS 334 FS GR + +G N WD L H V + + VAT S D Sbjct: 493 GFSPDGRFVFSGDSSGNACFWDWKTCKLMAKLPAHSGPVQSMAFHPQETSKVATSSIVDG 552 Query: 335 FLKIWN 340 +K W+ Sbjct: 553 SIKYWD 558 Score = 125 bits (315), Expect = 2e-29, Method: Composition-based stats. Identities = 45/289 (15%), Positives = 100/289 (34%), Gaps = 24/289 (8%) Query: 25 CADATLSQITNNIDPVGRI-QMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWD 83 + N I RT +GH I + + D R +S S D + +WD Sbjct: 279 GHLLLSGSMDNQIKIWEVYHDRSLLRTFQGHARPIRDLSFSQDGRSFLSTSFDKTIKLWD 338 Query: 84 SYTTNKVHAIPLRSSWVMTCAY--APSG-NYVACGGLDNICSIYNLKTREGNVRVSRELA 140 + ++ + P N G D +++++ + + + Sbjct: 339 TELGKCLNCF-NSDRLTNCVKFQVDPDKPNEFLAGTADKRILQFDIRSPD----IVQAYD 393 Query: 141 GHTGYLSCCRFL-DDNQIVTSSGDTTCALWDIETG---QQTTTFTGHTGDVMSLSLAPDT 196 H G ++ FL + + VT+S D++ W+ T + H+ ++L P+ Sbjct: 394 HHLGGINSITFLENGKRFVTTSDDSSMRFWEYGTPVPIKFVADIAMHSMP--RVALRPNG 451 Query: 197 RLFVSGACDASAKLWDVREG---MCRQTFTGH--ESDINAICFFPNGNAFATGSDDATCR 251 + + D ++ E ++ F G+ + F P+G +G Sbjct: 452 KSIACQSLDNCIYVYSAYEKYRQNKKKVFKGYSCSGYSLEVGFSPDGRFVFSGDSSGNAC 511 Query: 252 LFDLRADQELMTYSHDNIICGITSVSFSK--SGRLLLAGYDDFNCNVWD 298 +D + + + + + S++F + ++ + D + WD Sbjct: 512 FWDWKTCKLMAKLPAHSG--PVQSMAFHPQETSKVATSSIVDGSIKYWD 558 >4AEZ-A nrPDB Length = 401 Score = 175 bits (443), Expect = 3e-44, Method: Composition-based stats. Identities = 58/288 (20%), Positives = 126/288 (43%), Gaps = 19/288 (6%) Query: 61 MHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPL-RSSWVMTCAYAPSGNYVACGGLDN 119 + W + +V+ + + + +W++ + + S++V + ++ G++++ G + Sbjct: 99 LDWSNLN--VVAVALERNVYVWNADSGSVSALAETDESTYVASVKWSHDGSFLSVGLGNG 156 Query: 120 ICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIE-TGQQTT 178 + IY+++++ R +AGH + C + + + + S D+ Q Sbjct: 157 LVDIYDVESQTK----LRTMAGHQARVGCLSWNR-HVLSSGSRSGAIHHHDVRIANHQIG 211 Query: 179 TFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFP-N 237 T GH+ +V L+ D SG D ++WD R + + T T H + + A+ + P Sbjct: 212 TLQGHSSEVCGLAWRSDGLQLASGGNDNVVQIWDARSSIPKFTKTNHNAAVKAVAWCPWQ 271 Query: 238 GNAFATGS--DDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLA--GYDDFN 293 N ATG D ++ + T + +TS+ +S + +++ G+ D N Sbjct: 272 SNLLATGGGTMDKQIHFWNAATGARVNTVDAGSQ---VTSLIWSPHSKEIMSTHGFPDNN 328 Query: 294 CNVWDALKA--DRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIW 339 ++W + + + HD RV ++ DG ++T + D LK W Sbjct: 329 LSIWSYSSSGLTKQVDIPAHDTRVLYSALSPDGRILSTAASDENLKFW 376 Score = 126 bits (317), Expect = 1e-29, Method: Composition-based stats. Identities = 40/256 (15%), Positives = 85/256 (33%), Gaps = 12/256 (4%) Query: 58 IYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGL 117 + ++ W D L +G + I+D + K+ + + V ++ + + ++ G Sbjct: 137 VASVKWSHDGSFLSVGLGNGLVDIYDVESQTKLRTMAGHQARVGCLSW--NRHVLSSGSR 194 Query: 118 DNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDN-QIVTSSGDTTCALWDIETGQQ 176 ++++ L GH+ + + D Q+ + D +WD + Sbjct: 195 SGAIHHHDVRIANHQ---IGTLQGHSSEVCGLAWRSDGLQLASGGNDNVVQIWDARSSIP 251 Query: 177 TTTFTGHTGDVMSLSLAPD-TRLFVSGA--CDASAKLWDVREGMCRQTFTGHESDINAIC 233 T T H V +++ P + L +G D W+ G T S + ++ Sbjct: 252 KFTKTNHNAAVKAVAWCPWQSNLLATGGGTMDKQIHFWNAATGARVNTVDA-GSQVTSLI 310 Query: 234 FFPNGNAFAT--GSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDD 291 + P+ + G D ++ + + + S GR+L D Sbjct: 311 WSPHSKEIMSTHGFPDNNLSIWSYSSSGLTKQVDIPAHDTRVLYSALSPDGRILSTAASD 370 Query: 292 FNCNVWDALKADRAGV 307 N W D Sbjct: 371 ENLKFWRVYDGDHVKR 386 Score = 108 bits (269), Expect = 4e-24, Method: Composition-based stats. Identities = 47/227 (20%), Positives = 90/227 (39%), Gaps = 20/227 (8%) Query: 9 QEAEQLKNQIRDARKACADATLSQITNNIDPVG-------RIQMRTRRTLRGHLAKIYAM 61 + +L+ + + + ++ G RI TL+GH +++ + Sbjct: 164 ESQTKLRTMAGHQARVGCLSWNRHVLSSGSRSGAIHHHDVRIANHQIGTLQGHSSEVCGL 223 Query: 62 HWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAP-SGNYVACGG--LD 118 W +D L S D + IWD+ ++ ++ V A+ P N +A GG +D Sbjct: 224 AWRSDGLQLASGGNDNVVQIWDARSSIPKFTKTNHNAAVKAVAWCPWQSNLLATGGGTMD 283 Query: 119 NICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLD-DNQIVTSSG--DTTCALWDIETGQ 175 +N T RV+ AG ++ + +I+++ G D ++W + Sbjct: 284 KQIHFWNAATG---ARVNTVDAGSQ--VTSLIWSPHSKEIMSTHGFPDNNLSIWSYSSSG 338 Query: 176 QTTT--FTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQ 220 T H V+ +L+PD R+ + A D + K W V +G + Sbjct: 339 LTKQVDIPAHDTRVLYSALSPDGRILSTAASDENLKFWRVYDGDHVK 385 Score = 74.0 bits (180), Expect = 8e-14, Method: Composition-based stats. Identities = 29/150 (19%), Positives = 66/150 (44%), Gaps = 6/150 (4%) Query: 193 APDTRLFVSGACDASAKLWDVREGMCRQTFTGHESD-INAICFFPNGNAFATGSDDATCR 251 V+ A + + +W+ G ES + ++ + +G+ + G + Sbjct: 100 DWSNLNVVAVALERNVYVWNADSGSVSALAETDESTYVASVKWSHDGSFLSVGLGNGLVD 159 Query: 252 LFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKAD-RAGVLAG 310 ++D+ + +L T + + +S+++ +L +G + D A+ + G L G Sbjct: 160 IYDVESQTKLRTMA--GHQARVGCLSWNRH--VLSSGSRSGAIHHHDVRIANHQIGTLQG 215 Query: 311 HDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 H + V L DG+ +A+G D+ ++IW+ Sbjct: 216 HSSEVCGLAWRSDGLQLASGGNDNVVQIWD 245 Score = 47.0 bits (110), Expect = 1e-05, Method: Composition-based stats. Identities = 16/94 (17%), Positives = 35/94 (37%), Gaps = 4/94 (4%) Query: 58 IYAMHWGTDSRLLVSASQ--DGKLIIWDSYTT--NKVHAIPLRSSWVMTCAYAPSGNYVA 113 + ++ W S+ ++S D L IW ++ K IP + V+ A +P G ++ Sbjct: 306 VTSLIWSPHSKEIMSTHGFPDNNLSIWSYSSSGLTKQVDIPAHDTRVLYSALSPDGRILS 365 Query: 114 CGGLDNICSIYNLKTREGNVRVSRELAGHTGYLS 147 D + + + R + ++ Sbjct: 366 TAASDENLKFWRVYDGDHVKRPIPITKTPSSSIT 399 >6EMK-B nrPDB Length = 303 Score = 174 bits (441), Expect = 4e-44, Method: Composition-based stats. Identities = 54/238 (22%), Positives = 99/238 (41%), Gaps = 14/238 (5%) Query: 111 YVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWD 170 + G D+ + T SR + ++ +D +++ ++G L+D Sbjct: 4 ILVSAGYDHTIRFWEALTG----VCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYD 59 Query: 171 IET--GQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESD 228 I T +F GH G+V S+S D R V+ + D + K+WDVR + + H + Sbjct: 60 IRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAP 118 Query: 229 INAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAG 288 +N + PN + D R++DL +Q + ++ + S+S + G +L A Sbjct: 119 VNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDD-TSLQSLSMASDGSMLAAA 177 Query: 289 YDDFNCNVW------DALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 NC VW DA H ++ + ++ D +AT S D ++W+ Sbjct: 178 NTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWS 235 Score = 173 bits (439), Expect = 8e-44, Method: Composition-based stats. Identities = 60/281 (21%), Positives = 105/281 (37%), Gaps = 11/281 (3%) Query: 67 SRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNL 126 S +LVSA D + W++ T I S V +A G N +Y++ Sbjct: 2 SVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQN-VRLYDI 60 Query: 127 KTREGNVRVSRELAGHTGYLSCCRFLDDNQ-IVTSSGDTTCALWDIETGQQTTTFTGHTG 185 +T N GH G ++ F DN+ +VTSS D T +WD+ + + H Sbjct: 61 RTTNPN--PVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNA 117 Query: 186 DVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESD-INAICFFPNGNAFATG 244 V + + P+ +S D + ++WD+ E C T + + ++ +G+ A Sbjct: 118 PVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAA 177 Query: 245 SDDATCRLFDLRA----DQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDA- 299 + C ++++ IT + S + L D VW Sbjct: 178 NTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSID 237 Query: 300 LKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 L GH V + D + T S D ++++W+ Sbjct: 238 DDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWD 278 Score = 142 bits (357), Expect = 2e-34, Method: Composition-based stats. Identities = 42/231 (18%), Positives = 93/231 (40%), Gaps = 12/231 (5%) Query: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109 + GH + ++ + D+R +V++S+DG + +WD + + ++ V P+ Sbjct: 70 SFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAPVNEVVIHPNQ 128 Query: 110 NYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALW 169 + D I++L + ++ T S D + + ++ C +W Sbjct: 129 GELISCDRDGNIRIWDLGENQCTHQL--TPEDDTSLQSLSMASDGSMLAAANTKGNCYVW 186 Query: 170 DIETG------QQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQT-F 222 ++ + T F H+ + + L+ D + + + D +A++W + + +T Sbjct: 187 EMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTL 246 Query: 223 TGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYS--HDNIIC 271 GH+ + F + T S D RL+DL + + Y H +C Sbjct: 247 DGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVC 297 Score = 73.6 bits (179), Expect = 1e-13, Method: Composition-based stats. Identities = 24/123 (19%), Positives = 44/123 (35%), Gaps = 5/123 (4%) Query: 32 QITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKV- 90 + + ++ R H I + +D + L + S D +W K+ Sbjct: 184 YVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLE 243 Query: 91 HAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCR 150 + WV CA++ Y+ D+ +++L TRE + R+ GH C Sbjct: 244 TTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTRE----IVRQYGGHHKGAVCVA 299 Query: 151 FLD 153 D Sbjct: 300 LND 302 >5OQL-X nrPDB Length = 630 Score = 174 bits (441), Expect = 4e-44, Method: Composition-based stats. Identities = 64/397 (16%), Positives = 126/397 (31%), Gaps = 75/397 (18%) Query: 4 LDQLRQEAEQLKNQIRDARKACADATLSQITNNI-DPVGRIQMRTRRTLRGHLAKIYAMH 62 L++ R+E EQL DA + D ++ ++ + G++ R L A Sbjct: 108 LEKTRKEVEQLDEYAFDAEEIDRDLLAERLKEDVAEAKGKVYRRLASELAFDKATYTQFR 167 Query: 63 WGT--------DSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVAC 114 W + + ++DG L W K+ +P ++ W T P Sbjct: 168 WNSGTVTSVAVCPPYAYTTTKDGYLTKW------KLQDLP-KNQWPQTTKKKPKKPPAPP 220 Query: 115 GGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIV-TSSGDTTCALWDIET 173 R+ N + GH + D + V T D +++ Sbjct: 221 KKRPERICFAKADARKAN---DKTYQGHLKAPLVVKASQDGKFVVTGGADKRLVVYNAAD 277 Query: 174 GQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAIC 233 + FT H V L+ T S + D + K+W + E +T GH+ +I I Sbjct: 278 LKPIKAFTQHRDAVTGLAFRRGTNQLYSCSKDRTVKVWSLDELAYVETLFGHQDEILDID 337 Query: 234 FFPNGNAFATGSDDATCRLFDLRADQELM------------------------TYSHDNI 269 + G+ D T R + + + +L+ + +H+ Sbjct: 338 ALGQERCVSVGARDRTARYWKVPEESQLVFRGGGEGGSSNTKKHKLPPGMDPASAAHEGS 397 Query: 270 ICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVL-AGHD---------------- 312 + + + + + G D+ + +W + V+ H Sbjct: 398 MDRVAMI----DDDMFVTGSDNGDLALWSIQRKKPLHVIARAHGLEPPIKLEDYSADEIP 453 Query: 313 ----------NRVSCLGVTDDGMAVATGSWDSFLKIW 339 ++ L + +GSWD +++W Sbjct: 454 DPSIIPAPQPRGITALRTLPYSDLIFSGSWDGCIRVW 490 Score = 103 bits (257), Expect = 1e-22, Method: Composition-based stats. Identities = 42/265 (15%), Positives = 82/265 (30%), Gaps = 58/265 (21%) Query: 49 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPS 108 +T +GHL + D + +V+ D +L+++++ + A V A+ Sbjct: 240 KTYQGHLKAPLVVKASQDGKFVVTGGADKRLVVYNAADLKPIKAFTQHRDAVTGLAFRRG 299 Query: 109 GNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFL-DDNQIVTSSGDTTCA 167 N + D +++L + L GH + L + + + D T Sbjct: 300 TNQLYSCSKDRTVKVWSLD----ELAYVETLFGHQDEILDIDALGQERCVSVGARDRTAR 355 Query: 168 LWDIETGQQTTTFTG------------------------HTGDVMSLSLAPDTRLFVSGA 203 W + Q F G H G + +++ D +FV+G+ Sbjct: 356 YWKVPEESQL-VFRGGGEGGSSNTKKHKLPPGMDPASAAHEGSMDRVAMI-DDDMFVTGS 413 Query: 204 CDASAKLWDVREGMCRQTF-TGH--------------------------ESDINAICFFP 236 + LW ++ H I A+ P Sbjct: 414 DNGDLALWSIQRKKPLHVIARAHGLEPPIKLEDYSADEIPDPSIIPAPQPRGITALRTLP 473 Query: 237 NGNAFATGSDDATCRLFDLRADQEL 261 + +GS D R++ L D+ Sbjct: 474 YSDLIFSGSWDGCIRVWRLSEDKRK 498 Score = 91.3 bits (225), Expect = 6e-19, Method: Composition-based stats. Identities = 33/220 (15%), Positives = 66/220 (30%), Gaps = 46/220 (20%) Query: 44 QMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTC 103 ++ + H + + + + L S S+D + +W V + ++ Sbjct: 277 DLKPIKAFTQHRDAVTGLAFRRGTNQLYSCSKDRTVKVWSLDELAYVETLFGHQDEILDI 336 Query: 104 AYAPSGNYVACGGLDNICSIYNLK---------TREGNVRVSREL----------AGHTG 144 V+ G D + + EG +++ A H G Sbjct: 337 DALGQERCVSVGARDRTARYWKVPEESQLVFRGGGEGGSSNTKKHKLPPGMDPASAAHEG 396 Query: 145 YLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTF-TGHTGD----------------- 186 + +DD+ VT S + ALW I+ + H + Sbjct: 397 SMDRVAMIDDDMFVTGSDNGDLALWSIQRKKPLHVIARAHGLEPPIKLEDYSADEIPDPS 456 Query: 187 ---------VMSLSLAPDTRLFVSGACDASAKLWDVREGM 217 + +L P + L SG+ D ++W + E Sbjct: 457 IIPAPQPRGITALRTLPYSDLIFSGSWDGCIRVWRLSEDK 496 Score = 80.1 bits (196), Expect = 1e-15, Method: Composition-based stats. Identities = 28/193 (14%), Positives = 57/193 (29%), Gaps = 40/193 (20%) Query: 184 TGDVMSLSLAPDTRLFVSGACDASAKLW---DVREGMCRQT------------------- 221 +G V S+++ P + D W D+ + QT Sbjct: 170 SGTVTSVAVCP--PYAYTTTKDGYLTKWKLQDLPKNQWPQTTKKKPKKPPAPPKKRPERI 227 Query: 222 --------------FTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHD 267 + GH + +G TG D +++ + + ++ Sbjct: 228 CFAKADARKANDKTYQGHLKAPLVVKASQDGKFVVTGGADKRLVVYNAADLKPIKAFT-- 285 Query: 268 NIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAV 327 +T ++F + L + D VW + L GH + + + V Sbjct: 286 QHRDAVTGLAFRRGTNQLYSCSKDRTVKVWSLDELAYVETLFGHQDEILDIDALGQERCV 345 Query: 328 ATGSWDSFLKIWN 340 + G+ D + W Sbjct: 346 SVGARDRTARYWK 358 >5OQL-d nrPDB Length = 446 Score = 166 bits (419), Expect = 2e-41, Method: Composition-based stats. Identities = 51/254 (20%), Positives = 98/254 (38%), Gaps = 16/254 (6%) Query: 95 LRSSWVMTCAYAPSG-NYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLD 153 V + + N +A G D + +++L TR+ + +A H + F + Sbjct: 64 GHVQGVYSMCKDKNSLNCIASGSGDGVVKVWDLTTRDEE---TWRVAAHNNIVKGLTFTN 120 Query: 154 DNQIVTSSGDTTCALWDIETGQQTTTFTG---HTGDVMSLSLAPDTRLFVSGACDASAKL 210 D ++++ + D LWD TT G SLS F + + ++ Sbjct: 121 DKKLLSCATDG-IKLWDPYASPSNTTPIATWQEGGPYTSLSFHRSANTFAASSGQGCIRI 179 Query: 211 WDVREGMCRQT--FTGHESDINAICFFP-NGNAFATGSDDATCRLFDLRADQELMTYSHD 267 WD+ Q + I +CF + + + D + LFDLR + ++ Sbjct: 180 WDLEHSTAGQAIQWPSFVDTITDVCFNQVETSVIGSVATDRSIILFDLRTNMPVIKTV-- 237 Query: 268 NIICGITSVSFSK-SGRLLLAGYDDFNCNVWDALKADRA-GVLAGHDNRVSCLGVTDDGM 325 + + F+ L +D N ++DA D+A + GH V + + G Sbjct: 238 -LHFACNRIVFNPMEAMNLAVASEDHNIYIFDARNFDKALNIQKGHVAAVMDVEFSPTGE 296 Query: 326 AVATGSWDSFLKIW 339 + +GS+D +++W Sbjct: 297 ELVSGSYDRTIRLW 310 Score = 148 bits (373), Expect = 3e-36, Method: Composition-based stats. Identities = 66/298 (22%), Positives = 108/298 (36%), Gaps = 19/298 (6%) Query: 53 GHLAKIYAMHWGTDS-RLLVSASQDGKLIIWDSYTTNKVH-AIPLRSSWVMTCAYAPSGN 110 GH+ +Y+M +S + S S DG + +WD T ++ + ++ V + Sbjct: 64 GHVQGVYSMCKDKNSLNCIASGSGDGVVKVWDLTTRDEETWRVAAHNNIVKGLTFTNDKK 123 Query: 111 YVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDD-NQIVTSSGDTTCALW 169 ++C D +++ N G + F N SSG +W Sbjct: 124 LLSCAT-DG-IKLWDPYASPSNTTPIATWQ-EGGPYTSLSFHRSANTFAASSGQGCIRIW 180 Query: 170 DIE---TGQQTTTFTGHTGDVMSLSLAP-DTRLFVSGACDASAKLWDVREGMCRQTFTGH 225 D+E GQ + + + +T + S A D S L+D+R M H Sbjct: 181 DLEHSTAGQAIQWPSF-VDTITDVCFNQVETSVIGSVATDRSIILFDLRTNMPVIKTVLH 239 Query: 226 ESDINAICFFPNGNA-FATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRL 284 N I F P A S+D +FD R + + + + V FS +G Sbjct: 240 F-ACNRIVFNPMEAMNLAVASEDHNIYIFDARNFDKALNI-QKGHVAAVMDVEFSPTGEE 297 Query: 285 LLAGYDDFNCNVWDALKADRAGVLAGHDN---RVSCLGVTDDGMAVATGSWDSFLKIW 339 L++G D +W V H RV T D + TGS D +++W Sbjct: 298 LVSGSYDRTIRLWRRDAGHSRDVY--HTKRMQRVFRTMWTMDSKYILTGSDDGNVRLW 353 Score = 135 bits (341), Expect = 2e-32, Method: Composition-based stats. Identities = 51/266 (19%), Positives = 98/266 (36%), Gaps = 11/266 (4%) Query: 48 RRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYT----TNKVHAIPLRSSWVMTC 103 + H + + + D + L+S + DG + +WD Y T + + + Sbjct: 103 TWRVAAHNNIVKGLTFTNDKK-LLSCATDG-IKLWDPYASPSNTTPIATWQEGGPY-TSL 159 Query: 104 AYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGD 163 ++ S N A I++L+ + T C ++ + I + + D Sbjct: 160 SFHRSANTFAASSGQGCIRIWDLEHSTAGQAIQWPSFVDTITDVCFNQVETSVIGSVATD 219 Query: 164 TTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRL-FVSGACDASAKLWDVRE-GMCRQT 221 + L+D+ T H + P + + D + ++D R Sbjct: 220 RSIILFDLRTNMPVIKTVLHFA-CNRIVFNPMEAMNLAVASEDHNIYIFDARNFDKALNI 278 Query: 222 FTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKS 281 GH + + + F P G +GS D T RL+ A Y H + + ++ Sbjct: 279 QKGHVAAVMDVEFSPTGEELVSGSYDRTIRLWRRDAGHSRDVY-HTKRMQRVFRTMWTMD 337 Query: 282 GRLLLAGYDDFNCNVWDALKADRAGV 307 + +L G DD N +W A ++R+GV Sbjct: 338 SKYILTGSDDGNVRLWRANASERSGV 363 Score = 65.9 bits (159), Expect = 2e-11, Method: Composition-based stats. Identities = 25/121 (20%), Positives = 45/121 (37%), Gaps = 7/121 (5%) Query: 224 GHESDINAICFFPNG-NAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSG 282 GH + ++C N N A+GS D +++DL E T+ + ++F+ Sbjct: 64 GHVQGVYSMCKDKNSLNCIASGSGDGVVKVWDLTTRDE-ETWRVAAHNNIVKGLTFTND- 121 Query: 283 RLLLAGYDDFNCNVWDAL-KADRAGVLAGHD--NRVSCLGVTDDGMAVATGSWDSFLKIW 339 + LL+ D +WD +A + L A S ++IW Sbjct: 122 KKLLSCATDG-IKLWDPYASPSNTTPIATWQEGGPYTSLSFHRSANTFAASSGQGCIRIW 180 Query: 340 N 340 + Sbjct: 181 D 181 Score = 33.5 bits (75), Expect = 0.15, Method: Composition-based stats. Identities = 9/33 (27%), Positives = 16/33 (48%), Gaps = 1/33 (3%) Query: 309 AGHDNRVSCLGVTDDG-MAVATGSWDSFLKIWN 340 GH V + + +A+GS D +K+W+ Sbjct: 63 NGHVQGVYSMCKDKNSLNCIASGSGDGVVKVWD 95 >6GMH-W nrPDB Length = 305 Score = 165 bits (417), Expect = 3e-41, Method: Composition-based stats. Identities = 54/295 (18%), Positives = 119/295 (40%), Gaps = 11/295 (3%) Query: 52 RGHLAKIYAMHWGTD----SRLLVSASQDGKLIIWDSYTT--NKVHAIPLRSSWVMTCAY 105 + H I+++ WGT+ S +V+ S D + +W + ++ V++ Sbjct: 13 QAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDI 72 Query: 106 APSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTT 165 + + A LD +++L+ + ++ AG + D + T + Sbjct: 73 SHTLPIAASSSLDAHIRLWDLENGK---QIKSIDAGPVDAWTLAFSPDSQYLATGTHVGK 129 Query: 166 CALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGH 225 ++ +E+G++ + ++S++ +PD + SGA D ++D+ G T GH Sbjct: 130 VNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGH 189 Query: 226 ESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLL 285 I ++ F P+ T SDD +++D++ T S + +V+F Sbjct: 190 AMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLS--GHASWVLNVAFCPDDTHF 247 Query: 286 LAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 ++ D + VWD H ++V + +G + + D + I++ Sbjct: 248 VSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302 Score = 163 bits (412), Expect = 1e-40, Method: Composition-based stats. Identities = 51/258 (19%), Positives = 118/258 (45%), Gaps = 7/258 (2%) Query: 44 QMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTC 103 ++ + +L GH + ++ + S+S D + +WD ++ +I T Sbjct: 53 RLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTL 112 Query: 104 AYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQ-IVTSSG 162 A++P Y+A G +I+ +++ + + ++ + D + + + + Sbjct: 113 AFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTR----GKFILSIAYSPDGKYLASGAI 168 Query: 163 DTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTF 222 D ++DI TG+ T GH + SL+ +PD++L V+ + D K++DV+ T Sbjct: 169 DGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTL 228 Query: 223 TGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSG 282 +GH S + + F P+ F + S D + +++D+ + T+ + + V ++ +G Sbjct: 229 SGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTF--FDHQDQVWGVKYNGNG 286 Query: 283 RLLLAGYDDFNCNVWDAL 300 +++ DD +++D Sbjct: 287 SKIVSVGDDQEIHIYDCP 304 Score = 148 bits (374), Expect = 3e-36, Method: Composition-based stats. Identities = 58/255 (22%), Positives = 106/255 (41%), Gaps = 9/255 (3%) Query: 91 HAIPLRSSWVMTCAY----APSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYL 146 + + A+ + V G LD++ ++ R+ + + L GH + Sbjct: 10 KQEQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKW--RDERLDLQWSLEGHQLGV 67 Query: 147 SCCRFLDDNQIV-TSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACD 205 I +SS D LWD+E G+Q + D +L+ +PD++ +G Sbjct: 68 VSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHV 127 Query: 206 ASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYS 265 ++ V G + I +I + P+G A+G+ D +FD+ + L T Sbjct: 128 GKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTL- 186 Query: 266 HDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGM 325 + I S++FS +LL+ DD ++D A+ AG L+GH + V + D Sbjct: 187 -EGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDT 245 Query: 326 AVATGSWDSFLKIWN 340 + S D +K+W+ Sbjct: 246 HFVSSSSDKSVKVWD 260 Score = 113 bits (283), Expect = 9e-26, Method: Composition-based stats. Identities = 37/180 (20%), Positives = 73/180 (40%), Gaps = 5/180 (2%) Query: 35 NNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIP 94 ++ G + +L I ++ + D + L S + DG + I+D T +H + Sbjct: 128 GKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLE 187 Query: 95 LRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRF-LD 153 + + + ++P + D IY+++ + ++ L+GH ++ F D Sbjct: 188 GHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQ----HANLAGTLSGHASWVLNVAFCPD 243 Query: 154 DNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDV 213 D V+SS D + +WD+ T TF H V + + VS D ++D Sbjct: 244 DTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYDC 303 Score = 84.7 bits (208), Expect = 5e-17, Method: Composition-based stats. Identities = 32/141 (22%), Positives = 59/141 (41%), Gaps = 5/141 (3%) Query: 31 SQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKV 90 I I+ + TL GH I ++ + DS+LLV+AS DG + I+D N Sbjct: 166 GAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLA 225 Query: 91 HAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCR 150 + +SWV+ A+ P + D ++++ TR H + + Sbjct: 226 GTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRT----CVHTFFDHQDQVWGVK 281 Query: 151 FL-DDNQIVTSSGDTTCALWD 170 + + ++IV+ D ++D Sbjct: 282 YNGNGSKIVSVGDDQEIHIYD 302 >3C9C-A nrPDB Length = 432 Score = 164 bits (414), Expect = 7e-41, Method: Composition-based stats. Identities = 62/282 (21%), Positives = 103/282 (36%), Gaps = 38/282 (13%) Query: 96 RSSWVMTCAYAP-SGNYVACGGLDNICSIYNLKTR------EGNVRVSRELAGHTGYLSC 148 V Y P + +A + +++ G + L GH Sbjct: 129 HEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYG 188 Query: 149 CRFLDD--NQIVTSSGDTTCALWDIETGQQ-------TTTFTGHTGDVMSLSLAP-DTRL 198 + + ++++S D T LWDI + FTGHT V ++ L Sbjct: 189 LSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESL 248 Query: 199 FVSGACDASAKLWDVREG---MCRQTFTGHESDINAICFFPNGN-AFATGSDDATCRLFD 254 F S A D +WD R T H +++N + F P ATGS D T L+D Sbjct: 249 FGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 308 Query: 255 LRADQELMTYSHDNIICGITSVSFSKSGRLLLAGY-DDFNCNVWDALK------------ 301 LR + +L +S ++ I V +S +LA D +VWD K Sbjct: 309 LR-NLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAED 367 Query: 302 --ADRAGVLAGHDNRVSCLGVTDDGMAVA-TGSWDSFLKIWN 340 + + GH ++S + + + S D+ +++W Sbjct: 368 GPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQ 409 Score = 147 bits (370), Expect = 9e-36, Method: Composition-based stats. Identities = 51/253 (20%), Positives = 95/253 (37%), Gaps = 31/253 (12%) Query: 34 TNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTD-SRLLVSASQDGKLIIWDSYTTNKVHA 92 + +P G Q R LRGH + Y + W + + L+SAS D + +WD T K H Sbjct: 164 PSKPEPSGECQPDLR--LRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHR 221 Query: 93 -------IPLRSSWVMTCAYA-PSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTG 144 ++ V A+ + D I++ + + S + HT Sbjct: 222 VIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNN-TSKPSHTVDAHTA 280 Query: 145 YLSCCRFLDDNQIV--TSSGDTTCALWDIETGQ-QTTTFTGHTGDVMSLSLAPDTR-LFV 200 ++C F ++ + T S D T ALWD+ + + +F H ++ + +P + Sbjct: 281 EVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILA 340 Query: 201 SGACDASAKLWDVRE--------------GMCRQTFTGHESDINAICFFPNGNAFATG-S 245 S D +WD+ + GH + I+ + PN S Sbjct: 341 SSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVS 400 Query: 246 DDATCRLFDLRAD 258 +D +++ + + Sbjct: 401 EDNIMQVWQMAEN 413 >5Y1U-A nrPDB Length = 456 Score = 163 bits (413), Expect = 8e-41, Method: Composition-based stats. Identities = 66/282 (23%), Positives = 103/282 (36%), Gaps = 38/282 (13%) Query: 96 RSSWVMTCAYAPSGNYV-ACGGLDNICSIYNLKTR------EGNVRVSRELAGHTGYLSC 148 V Y P + A + +++ G L GH Sbjct: 154 HEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYG 213 Query: 149 CRFLDD--NQIVTSSGDTTCALWDIET----GQQT---TTFTGHTGDVMSLSLA-PDTRL 198 + + ++++S D T LWDI G+ T FTGHT V +S L Sbjct: 214 LSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESL 273 Query: 199 FVSGACDASAKLWDVREG---MCRQTFTGHESDINAICFFPNGN-AFATGSDDATCRLFD 254 F S A D +WD R + H +++N + F P ATGS D T L+D Sbjct: 274 FGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 333 Query: 255 LRADQELMTYSHDNIICGITSVSFSKSGRLLLAGY-DDFNCNVWDALK------------ 301 LR + +L +S ++ I V +S +LA D NVWD K Sbjct: 334 LR-NLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAED 392 Query: 302 --ADRAGVLAGHDNRVSCLGVTDDGMAVA-TGSWDSFLKIWN 340 + + GH ++S + V + S D+ +++W Sbjct: 393 GPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQ 434 Score = 141 bits (355), Expect = 4e-34, Method: Composition-based stats. Identities = 49/253 (19%), Positives = 94/253 (37%), Gaps = 31/253 (12%) Query: 34 TNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTD-SRLLVSASQDGKLIIWDSYTTNKV-- 90 + DP G R LRGH + Y + W + S L+SAS D + +WD K Sbjct: 189 PSKPDPSGECNPDLR--LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGK 246 Query: 91 -----HAIPLRSSWVMTCAYA-PSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTG 144 ++ V ++ + D I++ ++ + S + HT Sbjct: 247 VVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNN-TSKPSHSVDAHTA 305 Query: 145 YLSCCRFLDDNQIV--TSSGDTTCALWDIETGQ-QTTTFTGHTGDVMSLSLAPDTR-LFV 200 ++C F ++ + T S D T ALWD+ + + +F H ++ + +P + Sbjct: 306 EVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILA 365 Query: 201 SGACDASAKLWDVRE--------------GMCRQTFTGHESDINAICFFPNGNA-FATGS 245 S D +WD+ + GH + I+ + PN + S Sbjct: 366 SSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVS 425 Query: 246 DDATCRLFDLRAD 258 +D +++ + + Sbjct: 426 EDNIMQVWQMAEN 438 >5K1B-B nrPDB Length = 677 Score = 163 bits (412), Expect = 1e-40, Method: Composition-based stats. Identities = 42/196 (21%), Positives = 86/196 (43%), Gaps = 10/196 (5%) Query: 155 NQIVTSSGDTTCALWDIETGQQ---TTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLW 211 N++ T+ D+ +W + +Q + HT V + L + + +S + D + K+W Sbjct: 43 NRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVW 102 Query: 212 DVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRA-------DQELMTY 264 + +G C T H+ + A+ + + A+ D L+D+ + + T Sbjct: 103 NAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTS 162 Query: 265 SHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDG 324 S I S++ ++ G ++++G + VWD + L GH + V L + DG Sbjct: 163 SLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDG 222 Query: 325 MAVATGSWDSFLKIWN 340 +GS D +++W+ Sbjct: 223 TQCLSGSSDGTIRLWS 238 Score = 161 bits (407), Expect = 4e-40, Method: Composition-based stats. Identities = 50/258 (19%), Positives = 94/258 (36%), Gaps = 7/258 (2%) Query: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109 ++ H + + + + L+SAS D + +W+++ + + +V AYA Sbjct: 70 SMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDK 129 Query: 110 NYVACGGLDNICSIYNLKTRE-----GNVRVSRELAGHTGYLSCCRFLD-DNQIVTSSGD 163 VA GLD ++++ T N + L+G+ + IV+ S + Sbjct: 130 ELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTE 189 Query: 164 TTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFT 223 +WD T + GHT +V +L L D +SG+ D + +LW + + C T+ Sbjct: 190 KVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYR 249 Query: 224 GHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGR 283 H+ + A+ +G D DLR + + + S Sbjct: 250 VHDEGVWALQVNDAFTHVYSGGRDRKIYCTDLRNPDIRVLICEEKAPVLKMELDRSADPP 309 Query: 284 L-LLAGYDDFNCNVWDAL 300 + N W Sbjct: 310 PAIWVATTKSTVNKWTLK 327 Score = 151 bits (382), Expect = 4e-37, Method: Composition-based stats. Identities = 52/252 (20%), Positives = 96/252 (38%), Gaps = 13/252 (5%) Query: 96 RSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFL-DD 154 + V P+ N + G D+I I+++ + + + HT +++ + Sbjct: 29 NRNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDP-YIASMEHHTDWVNDIVLCCNG 87 Query: 155 NQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVR 214 ++++S DTT +W+ G +T H V +L+ A D L S D LWDV Sbjct: 88 KTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVN 147 Query: 215 EGMCR---------QTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYS 265 + +G++ I ++ G +GS + R++D R +LM Sbjct: 148 TLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKL- 206 Query: 266 HDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGM 325 + ++ ++ G L+G D +W + HD V L V D Sbjct: 207 -KGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFT 265 Query: 326 AVATGSWDSFLK 337 V +G D + Sbjct: 266 HVYSGGRDRKIY 277 Score = 147 bits (370), Expect = 8e-36, Method: Composition-based stats. Identities = 51/262 (19%), Positives = 99/262 (37%), Gaps = 19/262 (7%) Query: 55 LAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNK---VHAIPLRSSWVMTCAYAPSGNY 111 + A+ L +A +D + IW + + ++ + WV +G Sbjct: 30 RNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKT 89 Query: 112 VACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSG-DTTCALWD 170 + D ++N L H Y+ + D ++V S+G D LWD Sbjct: 90 LISASSDTTVKVWNAHKGF----CMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWD 145 Query: 171 IETGQ---------QTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQT 221 + T T++ +G+ + SL++ + VSG+ + ++WD R Sbjct: 146 VNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMK 205 Query: 222 FTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKS 281 GH ++ A+ +G +GS D T RL+ L + + TY + G+ ++ + + Sbjct: 206 LKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDE--GVWALQVNDA 263 Query: 282 GRLLLAGYDDFNCNVWDALKAD 303 + +G D D D Sbjct: 264 FTHVYSGGRDRKIYCTDLRNPD 285 Score = 89.0 bits (219), Expect = 2e-18, Method: Composition-based stats. Identities = 24/116 (20%), Positives = 47/116 (40%), Gaps = 1/116 (0%) Query: 226 ESDINAICFFPNGNAFATGSDDATCRLFDLRADQE-LMTYSHDNIICGITSVSFSKSGRL 284 + +NA+ P N T D+ R++ + ++ S ++ + + +G+ Sbjct: 30 RNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKT 89 Query: 285 LLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 L++ D VW+A K L H + V L D VA+ D + +W+ Sbjct: 90 LISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWD 145 Score = 86.3 bits (212), Expect = 2e-17, Method: Composition-based stats. Identities = 47/268 (17%), Positives = 78/268 (29%), Gaps = 29/268 (10%) Query: 44 QMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTC 103 T +L G+ IY++ ++VS S + L +WD T K+ + + V Sbjct: 157 NTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKAL 216 Query: 104 AYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDD-NQIVTSSG 162 G G D +++L G R H + + D + + Sbjct: 217 LLNRDGTQCLSGSSDGTIRLWSL----GQQRCIATYRVHDEGVWALQVNDAFTHVYSGGR 272 Query: 163 DTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTF 222 D D+ V+ + L + D +W + Sbjct: 273 DRKIYCTDLRNPDIRVLICEEKAPVLKMELDR--------SADPPPAIWVATTKSTVNKW 324 Query: 223 TGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFS--K 280 + I N A+G D C L T I G + + Sbjct: 325 -----TLKGIH-----NFRASGDYDNDC----TNPITPLCTQPDQVIKGGASIIQCHILN 370 Query: 281 SGRLLLAGYDDFNCNVWDALKADRAGVL 308 R +L + N WD LKA + L Sbjct: 371 DKRHILTKDTNNNVAYWDVLKACKVEDL 398 Score = 36.2 bits (82), Expect = 0.021, Method: Composition-based stats. Identities = 23/153 (15%), Positives = 44/153 (28%), Gaps = 21/153 (13%) Query: 40 VGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSW 99 Q R T R H ++A+ + S +D K+ D + I + Sbjct: 237 WSLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDLRNPDIRVLICEEKAP 296 Query: 100 VMTCAYAPSGNY---VACGGLDNICSIYNLKTREG------------------NVRVSRE 138 V+ S + + + + + LK + + Sbjct: 297 VLKMELDRSADPPPAIWVATTKSTVNKWTLKGIHNFRASGDYDNDCTNPITPLCTQPDQV 356 Query: 139 LAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDI 171 + G + C D I+T + A WD+ Sbjct: 357 IKGGASIIQCHILNDKRHILTKDTNNNVAYWDV 389 >5OQL-J nrPDB Length = 912 Score = 161 bits (408), Expect = 4e-40, Method: Composition-based stats. Identities = 64/336 (19%), Positives = 120/336 (35%), Gaps = 51/336 (15%) Query: 55 LAKIYAMHWGTDSRLLVSA------SQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPS 108 + A+ ++ +VS S+D SY + V + VM+ S Sbjct: 385 DQSMMAIATNSEDIRIVSVKDAQAYSEDNAECRSGSYFGHDVALLKGHEDIVMSLDVDWS 444 Query: 109 GNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRF----------------- 151 G+++A G DN ++ + + GH + Sbjct: 445 GHWIASGSKDNTARLWRVDPANNSYTCYAVFTGHLESVGAVALPKVVPPANSEAFKNPLD 504 Query: 152 LDDNQIVTSSGDTTCALWDIE-----TGQQTTTFT--GHTGDVMSLSLAPDTRLFVSGAC 204 +++ S D DI G+ T++ H D+ +L ++P+ +LF S + Sbjct: 505 HPPAFLISGSQDRFVQKRDIPRQLQKGGKLTSSLRRLAHDKDINALDISPNGKLFASASQ 564 Query: 205 DASAKLWDVREGMCRQTFTGHESDINAICFFP--------------NGNAFATGSDDATC 250 D + K+WDV + + GH+ + + F P TGS D T Sbjct: 565 DKTVKIWDVEKLEVQGILRGHKRGVWTVRFAPLNTPVIQGEQGSVSGRGVVLTGSGDKTI 624 Query: 251 RLFDLRADQELMTYS-HDNIICGITSVSFSKSGRL------LLAGYDDFNCNVWDALKAD 303 +L++L + T+ H + + + + S+ + + D VWDA + Sbjct: 625 KLWNLSDYTCIRTFEGHSHNVLKVVWLHISRDDSITKTKVQFASAGADTLVKVWDANTGE 684 Query: 304 RAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIW 339 L H++R+ L V +A+ DS + W Sbjct: 685 TECTLDNHEDRLWTLAVHSKTNILASAGSDSKVTFW 720 Score = 158 bits (399), Expect = 4e-39, Method: Composition-based stats. Identities = 74/354 (20%), Positives = 118/354 (33%), Gaps = 77/354 (21%) Query: 60 AMHWGTDSRLLVSASQDGKLIIWDSYTTN---KVHAIPLRSSWVMTCAYAPSGNYVACGG 116 ++ + + + + SA G L IWD+ T + K +++ P + + C Sbjct: 279 SVGFLNEGKWMYSAGTSGVLRIWDTTTHHEITKKQDAKSEGEAILSAVSLPERSLILCAQ 338 Query: 117 LDNICSIYNLKTREGNV--------RVSRELAG-HTGYLSCCRFLDDNQ---IVTSSGD- 163 D +Y + + V R ++G H L L D I T+S D Sbjct: 339 ADFTLVLYRVPSPADVVSSSEGILLEPFRRISGTHDEILDLTYILPDQSMMAIATNSEDI 398 Query: 164 TTCALWDIET--------------GQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAK 209 ++ D + G GH VMSL + SG+ D +A+ Sbjct: 399 RIVSVKDAQAYSEDNAECRSGSYFGHDVALLKGHEDIVMSLDVDWSGHWIASGSKDNTAR 458 Query: 210 LWDVREG----MCRQTFTGHESDINAICF-----------------FPNGNAFATGSDDA 248 LW V C FTGH + A+ P +GS D Sbjct: 459 LWRVDPANNSYTCYAVFTGHLESVGAVALPKVVPPANSEAFKNPLDHP-PAFLISGSQDR 517 Query: 249 TCRLFDLRADQE--------LMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDAL 300 + D+ + L +HD I ++ S +G+L + D +WD Sbjct: 518 FVQKRDIPRQLQKGGKLTSSLRRLAHDKD---INALDISPNGKLFASASQDKTVKIWDVE 574 Query: 301 KADRAGVLAGHDNRVSCLGVTD--------------DGMAVATGSWDSFLKIWN 340 K + G+L GH V + V TGS D +K+WN Sbjct: 575 KLEVQGILRGHKRGVWTVRFAPLNTPVIQGEQGSVSGRGVVLTGSGDKTIKLWN 628 Score = 122 bits (305), Expect = 3e-28, Method: Composition-based stats. Identities = 45/204 (22%), Positives = 71/204 (34%), Gaps = 30/204 (14%) Query: 33 ITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHA 92 I + G++ RR H I A+ + +L SASQD + IWD Sbjct: 524 IPRQLQKGGKLTSSLRRL--AHDKDINALDISPNGKLFASASQDKTVKIWDVEKLEVQGI 581 Query: 93 IPLRSSWVMTCAYAPSGN--------------YVACGGLDNICSIYNLKTREGNVRVSRE 138 + V T +AP V G D ++NL + R Sbjct: 582 LRGHKRGVWTVRFAPLNTPVIQGEQGSVSGRGVVLTGSGDKTIKLWNLS----DYTCIRT 637 Query: 139 LAGHTGYLSCCRFL----DDN------QIVTSSGDTTCALWDIETGQQTTTFTGHTGDVM 188 GH+ + +L DD+ Q ++ DT +WD TG+ T H + Sbjct: 638 FEGHSHNVLKVVWLHISRDDSITKTKVQFASAGADTLVKVWDANTGETECTLDNHEDRLW 697 Query: 189 SLSLAPDTRLFVSGACDASAKLWD 212 +L++ T + S D+ W Sbjct: 698 TLAVHSKTNILASAGSDSKVTFWR 721 Score = 116 bits (290), Expect = 1e-26, Method: Composition-based stats. Identities = 70/411 (17%), Positives = 136/411 (33%), Gaps = 80/411 (19%) Query: 7 LRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTD 66 LR E + + + + + T S + D ++ ++ + I + + Sbjct: 272 LRHELLESVGFLNEGKWMYSAGT-SGVLRIWDTTTHHEITKKQDAKSEGEAILSAVSLPE 330 Query: 67 SRLLVSASQDGKLIIWDSYTT------------NKVHAIPLRSSWVMTCAYA-PSGNYVA 113 L++ A D L+++ + I ++ Y P + +A Sbjct: 331 RSLILCAQADFTLVLYRVPSPADVVSSSEGILLEPFRRISGTHDEILDLTYILPDQSMMA 390 Query: 114 CGGLDNICSIYNLKTREGNVRVSRE-------------LAGHTGYLSCCRF-LDDNQIVT 159 I ++K + + E L GH + + I + Sbjct: 391 IATNSEDIRIVSVKDAQAYSEDNAECRSGSYFGHDVALLKGHEDIVMSLDVDWSGHWIAS 450 Query: 160 SSGDTTCALWDIE----TGQQTTTFTGHTGDVMSLS---LAPDTR-------------LF 199 S D T LW ++ + FTGH V +++ + P Sbjct: 451 GSKDNTARLWRVDPANNSYTCYAVFTGHLESVGAVALPKVVPPANSEAFKNPLDHPPAFL 510 Query: 200 VSGACDASAKLWDV-----REGMCRQTFT--GHESDINAICFFPNGNAFATGSDDATCRL 252 +SG+ D + D+ + G + H+ DINA+ PNG FA+ S D T ++ Sbjct: 511 ISGSQDRFVQKRDIPRQLQKGGKLTSSLRRLAHDKDINALDISPNGKLFASASQDKTVKI 570 Query: 253 FDLRADQELMTYSHDNIICGITSVSFSK-------------SGR-LLLAGYDDFNCNVWD 298 +D+ + G+ +V F+ SGR ++L G D +W+ Sbjct: 571 WDVEKLEVQGIL--RGHKRGVWTVRFAPLNTPVIQGEQGSVSGRGVVLTGSGDKTIKLWN 628 Query: 299 ALKADRAGVLAGHDNRVSCLGV---TDDGMA------VATGSWDSFLKIWN 340 GH + V + + D A+ D+ +K+W+ Sbjct: 629 LSDYTCIRTFEGHSHNVLKVVWLHISRDDSITKTKVQFASAGADTLVKVWD 679 Score = 113 bits (283), Expect = 1e-25, Method: Composition-based stats. Identities = 56/364 (15%), Positives = 109/364 (29%), Gaps = 65/364 (17%) Query: 41 GRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWV 100 ++ RT + H + + S LL + + DG + IWD H + S V Sbjct: 97 DSVEPTLVRTTKPHATPVVVLAVDRTSTLLATGAADGAIKIWDIIGGYVTHTVSGPSVLV 156 Query: 101 MTCAY------------------------APSGNYVAC------GGLDNICSIYNLKTRE 130 + + +A G D I++L R Sbjct: 157 SALHFFEIAVTAESQSSNKKPKKGSRKGQNDDADEIASRFRLAWGTQDGRIRIFDLYKRT 216 Query: 131 GNV---RVSRELAGHTGYLSCCRFLDDNQ-IVTSSGDTTCALWDIETGQQTTTFTGHTGD 186 R+ H + C + + +++ S D T LW G T Sbjct: 217 TTPVYADPKRKKEAHESNVQCIAYSPEQHALLSGSRDKTMTLWLWRDGIWQGTPMLRHEL 276 Query: 187 VMSLSLAPDTRLFVSGACDASAKLWDV---REGMCRQTFTGHESDINAICFFPNGNAFAT 243 + S+ + + S ++WD E +Q I + P + Sbjct: 277 LESVGFLNEGKWMYSAGTSGVLRIWDTTTHHEITKKQDAKSEGEAILSAVSLPERSLILC 336 Query: 244 GSDDATCRLFDLRADQELMTYSHDNIICGITSVS-----------FSKSGRLLLAGYDDF 292 D T L+ + + ++++ S ++ +S ++ + Sbjct: 337 AQADFTLVLYRVPSPADVVSSSEGILLEPFRRISGTHDEILDLTYILPDQSMMAIATNSE 396 Query: 293 NCNVWDALKADR-----------------AGVLAGHDNRVSCLGVTDDGMAVATGSWDSF 335 + + A +L GH++ V L V G +A+GS D+ Sbjct: 397 DIRIVSVKDAQAYSEDNAECRSGSYFGHDVALLKGHEDIVMSLDVDWSGHWIASGSKDNT 456 Query: 336 LKIW 339 ++W Sbjct: 457 ARLW 460 Score = 107 bits (266), Expect = 9e-24, Method: Composition-based stats. Identities = 55/380 (14%), Positives = 116/380 (30%), Gaps = 68/380 (17%) Query: 21 ARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLI 80 A + A S + N + ++G I + L+ S+ + Sbjct: 27 ALENGARILASTLGENAILTELNTGKRLAEIQGDGEPISTLTITPSGSHLIVCSRSLTMR 86 Query: 81 IW--------DSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGN 132 I+ DS V ++ V+ A + +A G D I+++ Sbjct: 87 IYSLAISPDYDSVEPTLVRTTKPHATPVVVLAVDRTSTLLATGAADGAIKIWDIIGGY-- 144 Query: 133 VRVSRELAGHTGYLSCCRFL-----------------------DDN--------QIVTSS 161 V+ ++G + +S F +D+ ++ + Sbjct: 145 --VTHTVSGPSVLVSALHFFEIAVTAESQSSNKKPKKGSRKGQNDDADEIASRFRLAWGT 202 Query: 162 GDTTCALWDIE-------TGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVR 214 D ++D+ H +V ++ +P+ +SG+ D + LW R Sbjct: 203 QDGRIRIFDLYKRTTTPVYADPKRKKEAHESNVQCIAYSPEQHALLSGSRDKTMTLWLWR 262 Query: 215 EGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTY-SHDNIICGI 273 +G+ + T + ++ F G + R++D E+ + I Sbjct: 263 DGIWQGTPMLRHELLESVGFLNEGKWMYSAGTSGVLRIWDTTTHHEITKKQDAKSEGEAI 322 Query: 274 TSVSFSKSGRLLLAGYDDFNCNVWDALKA------------DRAGVLAGHDNRVSCLGV- 320 S L+L DF ++ + ++G + + L Sbjct: 323 LSAVSLPERSLILCAQADFTLVLYRVPSPADVVSSSEGILLEPFRRISGTHDEILDLTYI 382 Query: 321 TDDGMA--VATGSWDSFLKI 338 D +AT S D ++I Sbjct: 383 LPDQSMMAIATNSED--IRI 400 Score = 97.5 bits (241), Expect = 8e-21, Method: Composition-based stats. Identities = 47/284 (16%), Positives = 92/284 (32%), Gaps = 51/284 (17%) Query: 102 TCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDN-QIVTS 160 + A +A +N T + E+ G +S ++ Sbjct: 25 SVALENGARILASTLGENAI-----LTELNTGKRLAEIQGDGEPISTLTITPSGSHLIVC 79 Query: 161 SGDTTCALW--------DIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWD 212 S T ++ D T H V+ L++ + L +GA D + K+WD Sbjct: 80 SRSLTMRIYSLAISPDYDSVEPTLVRTTKPHATPVVVLAVDRTSTLLATGAADGAIKIWD 139 Query: 213 VREGMCRQTFTGHESDINAICF------------------------FPNGNAFAT----- 243 + G T +G ++A+ F + + A+ Sbjct: 140 IIGGYVTHTVSGPSVLVSALHFFEIAVTAESQSSNKKPKKGSRKGQNDDADEIASRFRLA 199 Query: 244 -GSDDATCRLFDL--RADQEL---MTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVW 297 G+ D R+FDL R + + + +++S LL+G D +W Sbjct: 200 WGTQDGRIRIFDLYKRTTTPVYADPKRKKEAHESNVQCIAYSPEQHALLSGSRDKTMTLW 259 Query: 298 DALKADRAGV-LAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 G + H+ + +G ++G + + L+IW+ Sbjct: 260 LWRDGIWQGTPMLRHE-LLESVGFLNEGKWMYSAGTSGVLRIWD 302 >5MWJ-A nrPDB Length = 337 Score = 161 bits (406), Expect = 5e-40, Method: Composition-based stats. Identities = 65/322 (20%), Positives = 111/322 (34%), Gaps = 52/322 (16%) Query: 24 ACADATLSQITNNID----PVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKL 79 AD + + D P R TL H + A+ +R + + + G + Sbjct: 17 VTADGQMQPVPFPPDALIGPGIPRHARQINTL-NHGEVVCAVTISNPTRHVYTGGK-GCV 74 Query: 80 IIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSREL 139 +WD P S V + + C DN Sbjct: 75 KVWDIS-------HPGNKSPV---------SQLDCLNRDNYIR----------------- 101 Query: 140 AGHTGYLSCCRFLDDNQIVTSSGDTTCALWDI--ETGQQTTTFTGHTGDVMSLSLAPDTR 197 SC D ++ +T ++WD+ T + T +L+++PD++ Sbjct: 102 -------SCKLLPDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSK 154 Query: 198 LFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRA 257 + S D + +WD+ + F GH + I +G TG D T R +DLR Sbjct: 155 VCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLRE 214 Query: 258 DQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSC 317 ++L + + I S+ + +G L G + N V K D+ L H++ V Sbjct: 215 GRQLQQH---DFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDKYQ-LHLHESCVLS 270 Query: 318 LGVTDDGMAVATGSWDSFLKIW 339 L G + D+ L W Sbjct: 271 LKFAYCGKWFVSTGKDNLLNAW 292 Score = 112 bits (279), Expect = 3e-25, Method: Composition-based stats. Identities = 45/245 (18%), Positives = 81/245 (33%), Gaps = 12/245 (4%) Query: 58 IYAMHWGTDSRLLVSASQDGKLIIWDS--YTTNKVHAIPLRSSWVMTCAYAPSGNYVACG 115 I + D L+ + L IWD T + + A +P Sbjct: 100 IRSCKLLPDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSC 159 Query: 116 GLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDN-QIVTSSGDTTCALWDIETG 174 D ++++L + + R+ GHT SC +D ++ T D T WD+ G Sbjct: 160 CSDGNIAVWDLHNQT----LVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREG 215 Query: 175 QQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICF 234 +Q T + SL P G ++ ++ V + Q HES + ++ F Sbjct: 216 RQLQQHDF-TSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDKYQ-LHLHESCVLSLKF 273 Query: 235 FPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNC 294 G F + D + + + S S + ++ G D Sbjct: 274 AYCGKWFVSTGKDNLLNAWRTPYGASIFQ---SKESSSVLSCDISVDDKYIVTGSGDKKA 330 Query: 295 NVWDA 299 V++ Sbjct: 331 TVYEV 335 Score = 109 bits (271), Expect = 2e-24, Method: Composition-based stats. Identities = 34/171 (19%), Positives = 69/171 (40%), Gaps = 7/171 (4%) Query: 175 QQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVR---EGMCRQTFT--GHESDI 229 +Q T H V +++++ TR +G K+WD+ ++ I Sbjct: 43 RQINTLN-HGEVVCAVTISNPTRHVYTGGK-GCVKVWDISHPGNKSPVSQLDCLNRDNYI 100 Query: 230 NAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGY 289 + P+G G + +T ++DL A + + +++ S ++ + Sbjct: 101 RSCKLLPDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCC 160 Query: 290 DDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 D N VWD GH + SC+ +++DG + TG D+ ++ W+ Sbjct: 161 SDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWD 211 Score = 93.2 bits (230), Expect = 1e-19, Method: Composition-based stats. Identities = 48/263 (18%), Positives = 84/263 (31%), Gaps = 23/263 (8%) Query: 1 MSELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVG-----RIQMRTRRTLRGHL 55 +S+LD L + N IR + K D + + R + L Sbjct: 88 VSQLDCLNR-----DNYIR-SCKLLPDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSA 141 Query: 56 AKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACG 115 YA+ DS++ S DG + +WD + V + + G + G Sbjct: 142 PACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTG 201 Query: 116 GLDNICSIYNLKTREGNVRVSRELAGH--TGYLSCCRFLDDNQ-IVTSSGDTTCALWDIE 172 GLDN ++L+ R+L H T + + + + + + + Sbjct: 202 GLDNTVRSWDLREG-------RQLQQHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHV- 253 Query: 173 TGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAI 232 H V+SL A + FVS D W G S + + Sbjct: 254 NKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKE-SSSVLSC 312 Query: 233 CFFPNGNAFATGSDDATCRLFDL 255 + TGS D ++++ Sbjct: 313 DISVDDKYIVTGSGDKKATVYEV 335 >3CFV-B nrPDB Length = 414 Score = 160 bits (405), Expect = 7e-40, Method: Composition-based stats. Identities = 63/282 (22%), Positives = 102/282 (36%), Gaps = 38/282 (13%) Query: 96 RSSWVMTCAYAPSGNYV-ACGGLDNICSIYNLKTR------EGNVRVSRELAGHTGYLSC 148 V Y P ++ A + +++ G L GH Sbjct: 125 HEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGYG 184 Query: 149 CRFLDD--NQIVTSSGDTTCALWDIETGQQ-------TTTFTGHTGDVMSLSLA-PDTRL 198 + + ++++S D T LWDI G + FTGH+ V ++ L Sbjct: 185 LSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESL 244 Query: 199 FVSGACDASAKLWDVREG---MCRQTFTGHESDINAICFFPNGN-AFATGSDDATCRLFD 254 F S A D +WD R H +++N + F P ATGS D T L+D Sbjct: 245 FGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 304 Query: 255 LRADQELMTYSHDNIICGITSVSFSKSGRLLLAGY-DDFNCNVWDALK------------ 301 LR + +L ++ ++ I V +S +LA D NVWD K Sbjct: 305 LR-NLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAED 363 Query: 302 --ADRAGVLAGHDNRVSCLGVTDDGMAVA-TGSWDSFLKIWN 340 + + GH ++S + V + S D+ ++IW Sbjct: 364 GPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQ 405 Score = 139 bits (350), Expect = 2e-33, Method: Composition-based stats. Identities = 52/253 (20%), Positives = 94/253 (37%), Gaps = 31/253 (12%) Query: 34 TNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTD-SRLLVSASQDGKLIIWDSYTTNKV-- 90 DP G R LRGH + Y + W ++ S L+SAS D + +WD K Sbjct: 160 PAKPDPSGECNPDLR--LRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGK 217 Query: 91 -----HAIPLRSSWVMTCAYA-PSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTG 144 S+ V A+ + D I++ ++ + S + HT Sbjct: 218 IVDAKAIFTGHSAVVEDVAWHLLHESLFGSVADDQKLMIWDTRSNT-TSKPSHLVDAHTA 276 Query: 145 YLSCCRFLDDNQIV--TSSGDTTCALWDIETGQ-QTTTFTGHTGDVMSLSLAPDTR-LFV 200 ++C F ++ + T S D T ALWD+ + + TF H ++ + +P + Sbjct: 277 EVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILA 336 Query: 201 SGACDASAKLWDVRE--------------GMCRQTFTGHESDINAICFFPNGNA-FATGS 245 S D +WD+ + GH + I+ + PN + S Sbjct: 337 SSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVS 396 Query: 246 DDATCRLFDLRAD 258 +D +++ + + Sbjct: 397 EDNIMQIWQMAEN 409 >2HES-X nrPDB Length = 330 Score = 160 bits (405), Expect = 8e-40, Method: Composition-based stats. Identities = 58/323 (17%), Positives = 123/323 (38%), Gaps = 32/323 (9%) Query: 47 TRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLII----WDSYTTNKVHAIPLRSSWVMT 102 ++L+ + KI++ + +L + S D K+ + +D +T V + + Sbjct: 6 LIKSLKLYKEKIWSFDFSQ--GILATGSTDRKIKLVSVKYDDFTLIDVLDETAHKKAIRS 63 Query: 103 CAYAPSGNYVACGGLDNICSIYNLKT---REGNVRVSRELAGHTGYLSCCRFLDDN-QIV 158 A+ P + +A G D+ SI+ + R + + + GH + + +D + Sbjct: 64 VAWRPHTSLLAAGSFDSTVSIWAKEESADRTFEMDLLAIIEGHENEVKGVAWSNDGYYLA 123 Query: 159 TSSGDTTCALWDI----ETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVR 214 T S D + +W+ E + + H+ DV + P L S + D + ++W Sbjct: 124 TCSRDKSVWIWETDESGEEYECISVLQEHSQDVKHVIWHPSEALLASSSYDDTVRIWKDY 183 Query: 215 EG--MCRQTFTGHESDINAICFFPNGNA--FATGSDDATCRLF-------DLRADQELMT 263 + C GHE + + F +GSDD+T R++ D + + Sbjct: 184 DDDWECVAVLNGHEGTVWSSDFDKTEGVFRLCSGSDDSTVRVWKYMGDDEDDQQEWVCEA 243 Query: 264 YSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLA------GHDNRVSC 317 D + +V++ +G L+ + D V++ + + ++ V Sbjct: 244 ILPDVHKRQVYNVAWGFNG-LIASVGADGVLAVYEEVDGEWKVFAKRALCHGVYEINVVK 302 Query: 318 LGVTDDGMAVATGSWDSFLKIWN 340 + +ATG D + W+ Sbjct: 303 WLELNGKTILATGGDDGIVNFWS 325 Score = 125 bits (314), Expect = 3e-29, Method: Composition-based stats. Identities = 53/275 (19%), Positives = 100/275 (36%), Gaps = 26/275 (9%) Query: 53 GHLAKIYAMHWGTDSRLLVSASQDGKLIIW-------DSYTTNKVHAIPLRSSWVMTCAY 105 H I ++ W + LL + S D + IW ++ + + I + V A+ Sbjct: 56 AHKKAIRSVAWRPHTSLLAAGSFDSTVSIWAKEESADRTFEMDLLAIIEGHENEVKGVAW 115 Query: 106 APSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIV-TSSGDT 164 + G Y+A D I+ L H+ + + ++ +SS D Sbjct: 116 SNDGYYLATCSRDKSVWIWETDESGEEYECISVLQEHSQDVKHVIWHPSEALLASSSYDD 175 Query: 165 TCALWDIETG--QQTTTFTGHTGDVMSLSLAPDTRLF--VSGACDASAKLW--------D 212 T +W + GH G V S +F SG+ D++ ++W D Sbjct: 176 TVRIWKDYDDDWECVAVLNGHEGTVWSSDFDKTEGVFRLCSGSDDSTVRVWKYMGDDEDD 235 Query: 213 VREGMCRQTFTG-HESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHD--NI 269 +E +C H+ + + + NG A+ D +++ + + + Sbjct: 236 QQEWVCEAILPDVHKRQVYNVAWGFNG-LIASVGADGVLAVYEEVDGEWKVFAKRALCHG 294 Query: 270 ICGITSVSFSK-SGR-LLLAGYDDFNCNVWDALKA 302 + I V + + +G+ +L G DD N W KA Sbjct: 295 VYEINVVKWLELNGKTILATGGDDGIVNFWSLEKA 329 Score = 114 bits (285), Expect = 7e-26, Method: Composition-based stats. Identities = 45/236 (19%), Positives = 84/236 (35%), Gaps = 25/236 (10%) Query: 43 IQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTT----NKVHAIPLRSS 98 +M + GH ++ + W D L + S+D + IW++ + + + S Sbjct: 95 FEMDLLAIIEGHENEVKGVAWSNDGYYLATCSRDKSVWIWETDESGEEYECISVLQEHSQ 154 Query: 99 WVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDN--- 155 V + PS +A D+ I+ K + + L GH G + F Sbjct: 155 DVKHVIWHPSEALLASSSYDDTVRIW--KDYDDDWECVAVLNGHEGTVWSSDFDKTEGVF 212 Query: 156 QIVTSSGDTTCALW----DIETGQQTTTFTG-----HTGDVMSLSLAPDTRLFVSGACDA 206 ++ + S D+T +W D E QQ H V +++ + L S D Sbjct: 213 RLCSGSDDSTVRVWKYMGDDEDDQQEWVCEAILPDVHKRQVYNVAWGFNG-LIASVGADG 271 Query: 207 SAKLWDVREGMC----RQTFTGHESDINAICF--FPNGNAFATGSDDATCRLFDLR 256 +++ +G ++ +IN + + ATG DD + L Sbjct: 272 VLAVYEEVDGEWKVFAKRALCHGVYEINVVKWLELNGKTILATGGDDGIVNFWSLE 327 >6J6H-n nrPDB Length = 455 Score = 159 bits (403), Expect = 1e-39, Method: Composition-based stats. Identities = 60/263 (22%), Positives = 102/263 (38%), Gaps = 18/263 (6%) Query: 90 VHAIPLRSSWVMTCAYAPS-GNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSC 148 + P + P G+ + GG D+ I++ + R+ GH + Sbjct: 155 IRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYH---DYECLRDFQGHNKPIKA 211 Query: 149 CRFLDDNQ-IVTSSGDTTCALWDIETGQQTTTFT--GHTGDVMSLSLAPDTRLFVSGACD 205 RF +D Q ++SS D + +WD ETG+ T DV S P F+ G + Sbjct: 212 LRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHE--FIVGLSN 269 Query: 206 ASAKLWDVREGM---CRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELM 262 + +D R QT+ H S I A+ +FP+G+ F + S+D T R+++ + + + Sbjct: 270 SKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIK 329 Query: 263 TYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDA---LKADRAGVLAGHD--NRVSC 317 S D + ++ S A D + K + GH Sbjct: 330 QIS-DTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGIS 388 Query: 318 LGVTDDGMAVATGSWDSFLKIWN 340 L + DG + +G S L W+ Sbjct: 389 LAFSGDGRYICSGDSKSRLFTWD 411 Score = 131 bits (329), Expect = 5e-31, Method: Composition-based stats. Identities = 55/351 (15%), Positives = 120/351 (34%), Gaps = 26/351 (7%) Query: 4 LDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGR---------IQMRTRRTLRGH 54 LD + E E++ + + K N++D R + + R GH Sbjct: 102 LDSEQIEVEEVSHFYGKSEKDYQGRGYLYPPNDVDVDLREERISFRCYLPKKVIRNYPGH 161 Query: 55 LAKIYAMHWGT-DSRLLVSASQDGKLIIWDSYTT-NKVHAIPLRSSWVMTCAYAPSGNYV 112 A+ + L++S D + IWD Y + + + + Sbjct: 162 PEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSF 221 Query: 113 ACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWD-- 170 D I++ +T + R+ T R + ++ + ++ +D Sbjct: 222 LSSSFDRSVKIWDTETGKVKTRLHLN---STPADVESRPTNPHEFIVGLSNSKILHYDDR 278 Query: 171 -IETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGH-ESD 228 E T+ H +++L PD F+S + D + ++W+ + + + + + Sbjct: 279 VSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHS 338 Query: 229 INAICFFPNGNAFATGSDDATCRLFDLRAD----QELMTYSHDNIICGITSVSFSKSGRL 284 + + P+ N F S D F L+ + + H + GI S++FS GR Sbjct: 339 MPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGI-SLAFSGDGRY 397 Query: 285 LLAGYDDFNCNVWDALKADRAGVLA-GHDNRVSCLGVTD--DGMAVATGSW 332 + +G WD + + + ++ + + +G+ Sbjct: 398 ICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQETSKVICSGAA 448 Score = 123 bits (309), Expect = 1e-28, Method: Composition-based stats. Identities = 46/261 (17%), Positives = 93/261 (35%), Gaps = 16/261 (6%) Query: 49 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPS 108 R +GH I A+ + D + +S+S D + IWD+ T KV +S P+ Sbjct: 200 RDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETG-KVKTRLHLNSTPADVESRPT 258 Query: 109 GNY-VACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDN-QIVTSSGDTTC 166 + G ++ Y+ + E + + H + ++ D + ++SS D T Sbjct: 259 NPHEFIVGLSNSKILHYDDRVSENQG-LVQTYDHHLSSILALKYFPDGSKFISSSEDKTV 317 Query: 167 ALWDIETGQQTTTFT---GHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREG---MCRQ 220 +W+ + + H+ L++ P F + + D + ++ ++ Sbjct: 318 RIWENQINVPIKQISDTAQHSMPF--LNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKK 375 Query: 221 TFTGHESDIN--AICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSF 278 F GH S ++ F +G +G + +D + L IT V + Sbjct: 376 IFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNK-PITQVDW 434 Query: 279 SKSG-RLLLAGYDDFNCNVWD 298 ++ V D Sbjct: 435 HPQETSKVICSGAAGKIYVCD 455 Score = 109 bits (272), Expect = 2e-24, Method: Composition-based stats. Identities = 33/172 (19%), Positives = 64/172 (37%), Gaps = 7/172 (4%) Query: 174 GQQTTTFTGHTGDVMSLSLAPD-TRLFVSGACDASAKLWD-VREGMCRQTFTGHESDINA 231 + + GH +L P L +SG D + K+WD + C + F GH I A Sbjct: 152 KKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKA 211 Query: 232 ICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDD 291 + F + +F + S D + +++D + ++ + S + + G + Sbjct: 212 LRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPH--EFIVGLSN 269 Query: 292 FNCNVWDALKADR---AGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 +D ++ H + + L DG + S D ++IW Sbjct: 270 SKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWE 321 Score = 40.8 bits (94), Expect = 8e-04, Method: Composition-based stats. Identities = 15/87 (17%), Positives = 35/87 (40%), Gaps = 4/87 (4%) Query: 41 GRIQMRTRRTLRGHLAKIY--AMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLR-S 97 + + ++ +GH + Y ++ + D R + S +L WD T+ ++ I + + Sbjct: 367 PKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGN 426 Query: 98 SWVMTCAYAP-SGNYVACGGLDNICSI 123 + + P + V C G + Sbjct: 427 KPITQVDWHPQETSKVICSGAAGKIYV 453 >4J0W-A nrPDB Length = 343 Score = 159 bits (403), Expect = 1e-39, Method: Composition-based stats. Identities = 66/306 (21%), Positives = 115/306 (37%), Gaps = 30/306 (9%) Query: 49 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAI-----------PLRS 97 R LRGH I + D + SA++D +I W + K+H I P S Sbjct: 8 RVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHS 67 Query: 98 SWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDD-NQ 156 S V+ A + G Y+A G + I+ ++ + GH +S F +Q Sbjct: 68 SHVLCMAISSDGKYLASGDRSKLILIWEAQS----CQHLYTFTGHRDAVSGLAFRRGTHQ 123 Query: 157 IVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREG 216 + ++S D + +W++ T GH V +L +G D + ++W + E Sbjct: 124 LYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPE- 182 Query: 217 MCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQE--LMTYSHD------- 267 + F GH+ I+ I N +G+DD + L+ L + L +H Sbjct: 183 ESQLVFYGHQGSIDCIHLI-NEEHMVSGADDGSVALWGLSKKRPLALQREAHGLRGEPGL 241 Query: 268 NIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGH---DNRVSCLGVTDDG 324 I+SV+ + L+ G +W + R L ++ L + G Sbjct: 242 EQPFWISSVAALLNTDLVATGSHSSCVRLWQCGEGFRQLDLLCDIPLVGFINSLKFSSSG 301 Query: 325 MAVATG 330 + G Sbjct: 302 DFLVAG 307 Score = 159 bits (402), Expect = 2e-39, Method: Composition-based stats. Identities = 55/271 (20%), Positives = 105/271 (38%), Gaps = 25/271 (9%) Query: 90 VHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAG-------H 142 + + + P + + D +++++ + R G H Sbjct: 7 IRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGH 66 Query: 143 TGYLSCCRFLDDNQIVTSSGDTT--CALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFV 200 + ++ C D + + +SGD + +W+ ++ Q TFTGH V L+ T Sbjct: 67 SSHVLCMAISSDGKYL-ASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLY 125 Query: 201 SGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQE 260 S + D S K+W+V E +T GH+ + A+ G D T R++ + + + Sbjct: 126 STSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQ 185 Query: 261 LMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLA-GHDNR----- 314 L+ Y H I I + + +++G DD + +W K + H R Sbjct: 186 LVFYGHQGSIDCIHLI----NEEHMVSGADDGSVALWGLSKKRPLALQREAHGLRGEPGL 241 Query: 315 -----VSCLGVTDDGMAVATGSWDSFLKIWN 340 +S + + VATGS S +++W Sbjct: 242 EQPFWISSVAALLNTDLVATGSHSSCVRLWQ 272 Score = 130 bits (327), Expect = 8e-31, Method: Composition-based stats. Identities = 58/292 (19%), Positives = 102/292 (34%), Gaps = 20/292 (6%) Query: 11 AEQLKNQIRDARKACADA-TLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRL 69 + I A K C+ + + + R + GH + + M +D + Sbjct: 22 VTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSHVLCMAISSDGKY 81 Query: 70 LVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTR 129 L S + ++IW++ + ++ V A+ + + D ++N+ Sbjct: 82 LASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNV--- 138 Query: 130 EGNVRVSRELAGHTGYLSCC-RFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVM 188 L GH ++ + + D T +W I Q F GH G + Sbjct: 139 -AENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQL-VFYGHQGSID 196 Query: 189 SLSLAPDTRLFVSGACDASAKLWDVREGMCRQT------FTGHES-----DINAICFFPN 237 + L + VSGA D S LW + + G I+++ N Sbjct: 197 CIHLI-NEEHMVSGADDGSVALWGLSKKRPLALQREAHGLRGEPGLEQPFWISSVAALLN 255 Query: 238 GNAFATGSDDATCRLFDLRADQELMTYSHDNIICG-ITSVSFSKSGRLLLAG 288 + ATGS + RL+ + D + G I S+ FS SG L+AG Sbjct: 256 TDLVATGSHSSCVRLWQCGEGFRQLDLLCDIPLVGFINSLKFSSSGDFLVAG 307 >4YCZ-A nrPDB Length = 876 Score = 157 bits (398), Expect = 4e-39, Method: Composition-based stats. Identities = 57/280 (20%), Positives = 98/280 (35%), Gaps = 36/280 (12%) Query: 52 RGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSY--TTNKVHAIPLRSSWVMTCAYAP-- 107 GH I+ R L + S D + I++ T + V ++A Sbjct: 15 SGHDDMIHDAVLDYYGRRLATCSSDRTIKIFEIEGETQRLTETLKGHDGAVWCVSWAHPK 74 Query: 108 SGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLD---DNQIVTSSGDT 164 GN +A G D I+ + G + + A H ++ + + +S D Sbjct: 75 YGNILASAGYDGKVLIW--RELNGAWQRIFDFALHKASVNVVSWSPHEAGCLLACASSDG 132 Query: 165 TCALWDIE-TGQQTTTFTGHTGDVMSLSLAP-----------------DTRLFVSGACDA 206 ++ + + + F H V S+S AP R FV+G D Sbjct: 133 NVSVLEFRDNSWEHSIFHAHGLGVNSVSWAPATSPGSIVSSKPGPKSTGNRRFVTGGSDN 192 Query: 207 SAKLW--DVREGMCR---QTFTGHESDINAICFFPN---GNAFATGSDDATCRLFDLRAD 258 + K+W D + + TGH + + + P + A+ S+D T R++ Sbjct: 193 ALKIWAYDPATNTYKLEREPLTGHTDWVRDVAWSPTVLQKSYIASASEDRTVRIWTSDPA 252 Query: 259 QELMTYSHD-NIICGITSVSFSKSGRLLLAGYDDFNCNVW 297 L N + VS+S SG +L A D +W Sbjct: 253 NPLQWNCKVLNFDAAVWRVSWSLSGNVLAASGGDNKVTLW 292 Score = 142 bits (358), Expect = 2e-34, Method: Composition-based stats. Identities = 45/244 (18%), Positives = 82/244 (33%), Gaps = 38/244 (15%) Query: 45 MRTRRTLRGHLAKIYAMHWGTD--SRLLVSASQDGKLIIWD--SYTTNKVHAIPLRSSWV 100 R TL+GH ++ + W +L SA DGK++IW + ++ L + V Sbjct: 52 QRLTETLKGHDGAVWCVSWAHPKYGNILASAGYDGKVLIWRELNGAWQRIFDFALHKASV 111 Query: 101 MTCAYAPS--GNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLD----- 153 +++P G +AC D S+ + N H ++ + Sbjct: 112 NVVSWSPHEAGCLLACASSDGNVSVLEFR---DNSWEHSIFHAHGLGVNSVSWAPATSPG 168 Query: 154 -------------DNQIVTSSGDTTCALW--DIETGQQTTT---FTGHTGDVMSLSLAP- 194 + + VT D +W D T TGHT V ++ +P Sbjct: 169 SIVSSKPGPKSTGNRRFVTGGSDNALKIWAYDPATNTYKLEREPLTGHTDWVRDVAWSPT 228 Query: 195 --DTRLFVSGACDASAKLWDVREGMCRQ---TFTGHESDINAICFFPNGNAFATGSDDAT 249 S + D + ++W Q ++ + + + +GN A D Sbjct: 229 VLQKSYIASASEDRTVRIWTSDPANPLQWNCKVLNFDAAVWRVSWSLSGNVLAASGGDNK 288 Query: 250 CRLF 253 L+ Sbjct: 289 VTLW 292 Score = 134 bits (338), Expect = 5e-32, Method: Composition-based stats. Identities = 49/234 (20%), Positives = 85/234 (36%), Gaps = 35/234 (14%) Query: 140 AGHTGYL-SCCRFLDDNQIVTSSGDTTCALWDIE--TGQQTTTFTGHTGDVMSLSL-APD 195 +GH + ++ T S D T +++IE T + T T GH G V +S P Sbjct: 15 SGHDDMIHDAVLDYYGRRLATCSSDRTIKIFEIEGETQRLTETLKGHDGAVWCVSWAHPK 74 Query: 196 -TRLFVSGACDASAKLWDVREGMCRQTFT--GHESDINAICFFPN--GNAFATGSDDATC 250 + S D +W G ++ F H++ +N + + P+ G A S D Sbjct: 75 YGNILASAGYDGKVLIWRELNGAWQRIFDFALHKASVNVVSWSPHEAGCLLACASSDGNV 134 Query: 251 RLFDLRADQELMTYSHDNIICGITSVSFSKS-----------------GRLLLAGYDDFN 293 + + R + + H G+ SVS++ + R + G D Sbjct: 135 SVLEFRDNSWEHSIFH-AHGLGVNSVSWAPATSPGSIVSSKPGPKSTGNRRFVTGGSDNA 193 Query: 294 CNVW--DALKADRA---GVLAGHDNRVSCLGVTDDG---MAVATGSWDSFLKIW 339 +W D L GH + V + + +A+ S D ++IW Sbjct: 194 LKIWAYDPATNTYKLEREPLTGHTDWVRDVAWSPTVLQKSYIASASEDRTVRIW 247 Score = 132 bits (331), Expect = 3e-31, Method: Composition-based stats. Identities = 48/291 (16%), Positives = 95/291 (32%), Gaps = 42/291 (14%) Query: 87 TNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYL 146 +V A + G +A D I+ ++ R++ L GH G + Sbjct: 8 GTQVIANSGHDDMIHDAVLDYYGRRLATCSSDRTIKIFEIEG--ETQRLTETLKGHDGAV 65 Query: 147 SCCRFLD---DNQIVTSSGDTTCALWDIETG--QQTTTFTGHTGDVMSLSLAPD--TRLF 199 C + N + ++ D +W G Q+ F H V +S +P L Sbjct: 66 WCVSWAHPKYGNILASAGYDGKVLIWRELNGAWQRIFDFALHKASVNVVSWSPHEAGCLL 125 Query: 200 VSGACDASAKLWDVREGMCRQ-TFTGHESDINAICFFP-----------------NGNAF 241 + D + + + R+ F H +N++ + P F Sbjct: 126 ACASSDGNVSVLEFRDNSWEHSIFHAHGLGVNSVSWAPATSPGSIVSSKPGPKSTGNRRF 185 Query: 242 ATGSDDATCRLF--DLRADQ-ELMTYSHDNIICGITSVSFSKS---GRLLLAGYDDFNCN 295 TG D +++ D + +L + V++S + + + +D Sbjct: 186 VTGGSDNALKIWAYDPATNTYKLEREPLTGHTDWVRDVAWSPTVLQKSYIASASEDRTVR 245 Query: 296 VWDALKADRAGVLAGH------DNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 +W +D A L + D V + + G +A D+ + +W Sbjct: 246 IW---TSDPANPLQWNCKVLNFDAAVWRVSWSLSGNVLAASGGDNKVTLWK 293 Score = 98.2 bits (243), Expect = 5e-21, Method: Composition-based stats. Identities = 34/193 (17%), Positives = 61/193 (31%), Gaps = 24/193 (12%) Query: 171 IETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDV--REGMCRQTFTGHESD 228 + G Q +GH + L R + + D + K++++ +T GH+ Sbjct: 5 MAAGTQVIANSGHDDMIHDAVLDYYGRRLATCSSDRTIKIFEIEGETQRLTETLKGHDGA 64 Query: 229 INAICF-FPN-GNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKS--GRL 284 + + + P GN A+ D ++ + + VS+S G L Sbjct: 65 VWCVSWAHPKYGNILASAGYDGKVLIWRELNGAWQRIFDFALHKASVNVVSWSPHEAGCL 124 Query: 285 LLAGYDDFNCNVWDALKADRA-GVLAGHDNRVSCLGVTD-----------------DGMA 326 L D N +V + + H V+ + Sbjct: 125 LACASSDGNVSVLEFRDNSWEHSIFHAHGLGVNSVSWAPATSPGSIVSSKPGPKSTGNRR 184 Query: 327 VATGSWDSFLKIW 339 TG D+ LKIW Sbjct: 185 FVTGGSDNALKIW 197 Score = 70.1 bits (170), Expect = 1e-12, Method: Composition-based stats. Identities = 24/110 (21%), Positives = 43/110 (39%), Gaps = 7/110 (6%) Query: 37 IDPVGRIQMRTRRTLRGHLAKIYAMHWGT---DSRLLVSASQDGKLIIWDSYTTNKVH-- 91 DP R L GH + + W + SAS+D + IW S N + Sbjct: 199 YDPATNTYKLEREPLTGHTDWVRDVAWSPTVLQKSYIASASEDRTVRIWTSDPANPLQWN 258 Query: 92 -AIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELA 140 + + V +++ SGN +A G DN +++ + +G + + Sbjct: 259 CKVLNFDAAVWRVSWSLSGNVLAASGGDNKVTLWK-ENLKGEWECVKTIE 307 >1NR0-A nrPDB Length = 611 Score = 157 bits (396), Expect = 9e-39, Method: Composition-based stats. Identities = 58/300 (19%), Positives = 111/300 (37%), Gaps = 18/300 (6%) Query: 54 HLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKV--HAIPLRSSWVMTCAY-APSGN 110 H + S G + IWD+ T + IP+ S V ++ + S Sbjct: 58 HSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKR 117 Query: 111 YVACG-GLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDN--QIVTSSGDTTCA 167 A G G + ++ T N L G ++ F +I++ S D T A Sbjct: 118 IAAVGEGRERFGHVFLFDTGTSNGN----LTGQARAMNSVDFKPSRPFRIISGSDDNTVA 173 Query: 168 LWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFT---- 223 +++ + +TF HT V S+ PD LF S D + L++ +G F Sbjct: 174 IFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSL 233 Query: 224 ---GHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSK 280 H + + + P+G A+ S D T +++++ + T I + Sbjct: 234 KNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIED-QQLGIIW 292 Query: 281 SGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 + + L++ + N + V GH+ ++ L + DG + + + + W+ Sbjct: 293 TKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWD 352 Score = 118 bits (296), Expect = 3e-27, Method: Composition-based stats. Identities = 52/376 (13%), Positives = 106/376 (28%), Gaps = 92/376 (24%) Query: 53 GHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIP------------------ 94 H ++ + W D + SAS D + IW+ T IP Sbjct: 237 AHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQA 296 Query: 95 -------------------------LRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTR 129 + + + + G + + + +++ T Sbjct: 297 LVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTG 356 Query: 130 EGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCAL--------------------- 168 N H ++ + + T S D + Sbjct: 357 ISNRVFPDV---HATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQ 413 Query: 169 -----------WDIETGQQTTTFTGHTGDV--------MSLSLAPDTRLFVSGACDASAK 209 + + H ++L+ D + G D+ Sbjct: 414 PLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVH 473 Query: 210 LWDVREGMCRQTFTG-HESDINAICFFPNGNAFATGSDDATCRLFDLRADQEL-MTYSHD 267 ++ + + T H ++I ++ F NG + + + EL T S Sbjct: 474 VYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWT 533 Query: 268 NIICGITSVSFSKSGRLLLAGYDDFNCNVWDALK-ADRAGVLAG-H-DNRVSCLGVTDDG 324 + VS+S L G D + VW+ K +D ++ G H + V+ + ++ Sbjct: 534 FHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNE- 592 Query: 325 MAVATGSWDSFLKIWN 340 + + DS +K WN Sbjct: 593 TTIVSAGQDSNIKFWN 608 Score = 107 bits (266), Expect = 1e-23, Method: Composition-based stats. Identities = 52/315 (16%), Positives = 106/315 (33%), Gaps = 15/315 (4%) Query: 34 TNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAI 93 N + + + T H ++++ + D L S DG +++++ K Sbjct: 169 DNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVF 228 Query: 94 P-------LRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYL 146 S V ++P G +A D I+N+ T + + L Sbjct: 229 EDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQL 288 Query: 147 SCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDA 206 +V+ S + + E G GH + +LS + D + S + Sbjct: 289 GIIW--TKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEG 346 Query: 207 SAKLWDVREGMCRQTFTG-HESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYS 265 WD+ G+ + F H + I I G+ F DD + + + Sbjct: 347 HINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAV 406 Query: 266 HDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGM 325 + + ++ S G + +A + ++ K + SC+ +++D Sbjct: 407 ANKLSSQPLGLAVSADGDIAVAA-CYKHIAIYSHGKLTEVPI----SYNSSCVALSNDKQ 461 Query: 326 AVATGSWDSFLKIWN 340 VA G DS + ++ Sbjct: 462 FVAVGGQDSKVHVYK 476 Score = 89.7 bits (221), Expect = 1e-18, Method: Composition-based stats. Identities = 42/292 (14%), Positives = 98/292 (33%), Gaps = 47/292 (16%) Query: 53 GHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIP-LRSSWVMTCAYAPSGNY 111 GH I A+ D + L SA +G + WD T P + ++ + G+ Sbjct: 322 GHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDL 381 Query: 112 VACGGLDNICSIYNLKTREGNVRVSRE---------------------------LAGH-- 142 D++ + + + + + H Sbjct: 382 FTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGK 441 Query: 143 ------TGYLSCCRFLDDNQIVTSSG-DTTCALWDIETGQQTTTFTG--HTGDVMSLSLA 193 + SC +D Q V G D+ ++ + +G + H ++ S++ + Sbjct: 442 LTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKL-SGASVSEVKTIVHPAEITSVAFS 500 Query: 194 PDTRLFVSGACDASAKLWDVREGMCRQ---TFTGHESDINAICFFPNGNAFATGSDDATC 250 + V+ + V ++T H + + + + P+ ATGS D + Sbjct: 501 NNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSV 560 Query: 251 RLFDLR--ADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDAL 300 ++++ +D ++ + + + SV + + +++ D N W+ Sbjct: 561 IVWNMNKPSDHPIIIKGA-HAMSSVNSVIW-LNETTIVSAGQDSNIKFWNVP 610 Score = 87.4 bits (215), Expect = 9e-18, Method: Composition-based stats. Identities = 39/230 (16%), Positives = 71/230 (30%), Gaps = 58/230 (25%) Query: 167 ALWDIETGQQTTT--FTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGM--CRQTF 222 +++ + G T T +T H+ +P SG + ++WD + + T Sbjct: 40 SVYTVPVGSLTDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTI 99 Query: 223 TGHESDINAICFFPNGNAFA---------------------------------------- 242 + I + A Sbjct: 100 PVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSR 159 Query: 243 -----TGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVW 297 +GSDD T +F+ + T+ + SV ++ G L + D ++ Sbjct: 160 PFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKF--VHSVRYNPDGSLFASTGGDGTIVLY 217 Query: 298 DALKADRAGVLA-------GHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 + + + GV H V L + DG +A+ S D +KIWN Sbjct: 218 NGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWN 267 >5WJC-A nrPDB Length = 430 Score = 154 bits (390), Expect = 4e-38, Method: Composition-based stats. Identities = 63/295 (21%), Positives = 101/295 (34%), Gaps = 40/295 (13%) Query: 84 SYTTNKVHAIPLRSSWVMTCAYAPSG-NYVACGGLDNICSIYNLKTRE----GNVRVSRE 138 SYT IP V Y P +A G I++ + G Sbjct: 119 SYTIEISQKIP-HDGDVNRARYMPQKPEIIATMGEGGNAYIFDTTCHDALTTGEALPQAV 177 Query: 139 LAGHTGYLSCCRFLDD--NQIVTSSGDTTCALWDIETGQ----------QTTTFTGHTGD 186 L GHT + + + T + D LWD++T + HT Sbjct: 178 LKGHTAEGFGLCWNPNLPGNLATGAEDQVICLWDVQTQSFTSSETKVISPIAKYHRHTDI 237 Query: 187 VMSLSLAPDTR-LFVSGACDASAKLWDVR---EGMCRQTFTGHESDINAICFFP-NGNAF 241 V + P L S + D + ++ D R E + H INA+ P N Sbjct: 238 VNDVQFHPQHEALLASVSDDCTLQIHDTRLNPEEEAPKVIQAHSKAINAVAINPFNDYLL 297 Query: 242 ATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKS-GRLLLAGYDDFNCNVWDAL 300 AT S D T L+DLR + ++ + + + +S +L + D +WD Sbjct: 298 ATASADKTVALWDLRNPYQ-RLHTLEGHEDEVYGLEWSPHDEPILASSSTDRRVCIWDLE 356 Query: 301 K--------------ADRAGVLAGHDNRVSCLGVTDDGMAVA-TGSWDSFLKIWN 340 K + + GH NR+S + V + + D+ L+IW+ Sbjct: 357 KIGEEQTPEDAEDGSPELLFMHGGHTNRISEFSWCPNERWVVGSLADDNILQIWS 411 Score = 130 bits (328), Expect = 7e-31, Method: Composition-based stats. Identities = 46/238 (19%), Positives = 89/238 (37%), Gaps = 32/238 (13%) Query: 48 RRTLRGHLAKIYAMHWGTD-SRLLVSASQDGKLIIWDSYTT----------NKVHAIPLR 96 + L+GH A+ + + W + L + ++D + +WD T + + Sbjct: 175 QAVLKGHTAEGFGLCWNPNLPGNLATGAEDQVICLWDVQTQSFTSSETKVISPIAKYHRH 234 Query: 97 SSWVMTCAYAPSGN-YVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLD-- 153 + V + P +A D I++ + + + H+ ++ Sbjct: 235 TDIVNDVQFHPQHEALLASVSDDCTLQIHDTRLNPEEEAP-KVIQAHSKAINAVAINPFN 293 Query: 154 DNQIVTSSGDTTCALWDIETG-QQTTTFTGHTGDVMSLSLAP-DTRLFVSGACDASAKLW 211 D + T+S D T ALWD+ Q+ T GH +V L +P D + S + D +W Sbjct: 294 DYLLATASADKTVALWDLRNPYQRLHTLEGHEDEVYGLEWSPHDEPILASSSTDRRVCIW 353 Query: 212 DVRE------------GMCRQTF--TGHESDINAICFFPNGNAFA-TGSDDATCRLFD 254 D+ + G F GH + I+ + PN + +DD +++ Sbjct: 354 DLEKIGEEQTPEDAEDGSPELLFMHGGHTNRISEFSWCPNERWVVGSLADDNILQIWS 411 Score = 58.5 bits (140), Expect = 4e-09, Method: Composition-based stats. Identities = 21/100 (21%), Positives = 40/100 (40%), Gaps = 16/100 (16%) Query: 42 RIQMRTRRTLRGHLAKIYAMHWGT-DSRLLVSASQDGKLIIWDSY--------------T 86 R + TL GH ++Y + W D +L S+S D ++ IWD + Sbjct: 312 RNPYQRLHTLEGHEDEVYGLEWSPHDEPILASSSTDRRVCIWDLEKIGEEQTPEDAEDGS 371 Query: 87 TNKVHAIPLRSSWVMTCAYAPSGNYVA-CGGLDNICSIYN 125 + ++ + ++ P+ +V DNI I++ Sbjct: 372 PELLFMHGGHTNRISEFSWCPNERWVVGSLADDNILQIWS 411 >5WYJ-BE nrPDB Length = 939 Score = 154 bits (390), Expect = 4e-38, Method: Composition-based stats. Identities = 51/323 (15%), Positives = 109/323 (33%), Gaps = 43/323 (13%) Query: 56 AKIYAMHWGTDSRLLVSASQDGKLI--IWD-----------SYTTNKVHAIPLRSSWVMT 102 + + ++V++ D L ++D + + S Sbjct: 296 GGVTQATFLNGQPIIVTSGGDNSLKEYVFDPSLSQGSGDVVVQPPRYLRSRGGHSQPPSY 355 Query: 103 CAYAPSGNY-VACGGLDNICSIYNLKTREGNVRVSRELAGHTG----------------Y 145 A+A S ++ + D S+++ R+ H Sbjct: 356 IAFADSQSHFMLSASKDR--SLWSFSLRKDAQSQEMSQRLHKKQDGGRVGGSTIKSKFPE 413 Query: 146 LSCCRFLDDN-----QIVTSSGDTTC-ALWDIETGQ--QTTTFTGHTGDVMSLSLAPDTR 197 + + I+T+ D WD+ + + T T G V S++++ Sbjct: 414 IVALAIENARIGEWENIITAHKDEKFARTWDMRNKRVGRWTFDTTDDGFVKSVAMSQCGN 473 Query: 198 LFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRA 257 G+ + S +++++ G+ R+ + H+ + I + D +D Sbjct: 474 FGFIGSSNGSITIYNMQSGILRKKYKLHKRAVTGISLDGMNRKMVSCGLDGIVGFYDFNK 533 Query: 258 DQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSC 317 L D IT++ + +S L DD + V DA+ L GH NR++ Sbjct: 534 STLLGKLKLD---APITAMVYHRSSDLFALALDDLSIVVIDAVTQRVVRQLWGHSNRITA 590 Query: 318 LGVTDDGMAVATGSWDSFLKIWN 340 + +G + + S DS ++ W+ Sbjct: 591 FDFSPEGRWIVSASLDSTIRTWD 613 Score = 101 bits (252), Expect = 5e-22, Method: Composition-based stats. Identities = 45/233 (19%), Positives = 82/233 (35%), Gaps = 13/233 (5%) Query: 70 LVSASQD-GKLIIWDSYTTNKVH-AI-PLRSSWVMTCAYAPSGNYVACGGLDNICSIYNL 126 +++A +D WD +V + A + GN+ G + +IYN+ Sbjct: 430 IITAHKDEKFARTWDMRNKRVGRWTFDTTDDGFVKSVAMSQCGNFGFIGSSNGSITIYNM 489 Query: 127 KTREGNVRVSRELAGHTGYLSCCRFLDDN-QIVTSSGDTTCALWDIETGQQTTTFTGHTG 185 ++ + ++ H ++ N ++V+ D +D Sbjct: 490 QSGI----LRKKYKLHKRAVTGISLDGMNRKMVSCGLDGIVGFYDFNKSTLLGKLKL-DA 544 Query: 186 DVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGS 245 + ++ + LF D S + D + GH + I A F P G + S Sbjct: 545 PITAMVYHRSSDLFALALDDLSIVVIDAVTQRVVRQLWGHSNRITAFDFSPEGRWIVSAS 604 Query: 246 DDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFN-CNVW 297 D+T R +DL + DN+ V FS +G LL + N +W Sbjct: 605 LDSTIRTWDLPTGGCIDGIIVDNVATN---VKFSPNGDLLATTHVTGNGICIW 654 Score = 70.5 bits (171), Expect = 1e-12, Method: Composition-based stats. Identities = 22/91 (24%), Positives = 40/91 (43%), Gaps = 2/91 (2%) Query: 36 NIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPL 95 +I + + R R L GH +I A + + R +VSAS D + WD T + I + Sbjct: 566 SIVVIDAVTQRVVRQLWGHSNRITAFDFSPEGRWIVSASLDSTIRTWDLPTGGCIDGIIV 625 Query: 96 RSSWVMTCAYAPSGNYVACGGLDNI-CSIYN 125 + ++P+G+ +A + I+ Sbjct: 626 -DNVATNVKFSPNGDLLATTHVTGNGICIWT 655 Score = 58.9 bits (141), Expect = 3e-09, Method: Composition-based stats. Identities = 45/258 (17%), Positives = 90/258 (34%), Gaps = 31/258 (12%) Query: 109 GNYVACGGLDNICSIYNLKTREGNV--RVSRELAGHT---GYLSCC----RFLDDNQIVT 159 G+Y+ DN IY + +L G + +L+ +VT Sbjct: 125 GDYLCASTDDNSIFIYKKSDPQDKYPSEFYTKLTVTEIQGGEIVSLQHLATYLNKLTVVT 184 Query: 160 SSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCR 219 S L+++ TG+ T + + AP + G ++++R+G Sbjct: 185 KS---NVLLFNVRTGKLVFTSNEFPDQITTAEPAPVLDIIALGTVTGEVIMFNMRKGKRI 241 Query: 220 QTFTGHESDINAICFFPNG-NAFATGSDDATCRLFDL--RADQELMTYSHDNIICGITSV 276 +T +S I+++ F +G + + G+ +DL R+ ++ H G+T Sbjct: 242 RTIKIPQSRISSLSFRTDGSSHLSVGTSSGDLIFYDLDRRSRIHVLKNIHRESYGGVTQA 301 Query: 277 SFSKSGRLLLAGYDDFNCN--VWDALKA--------DRAGVLA---GHDNRVSCLGVTDD 323 +F +++ D + V+D + L GH S + D Sbjct: 302 TFLNGQPIIVTSGGDNSLKEYVFDPSLSQGSGDVVVQPPRYLRSRGGHSQPPSYIAFADS 361 Query: 324 GMAV-ATGSWDSFLKIWN 340 + S D +W+ Sbjct: 362 QSHFMLSASKDRS--LWS 377 Score = 58.9 bits (141), Expect = 3e-09, Method: Composition-based stats. Identities = 20/117 (17%), Positives = 45/117 (38%), Gaps = 7/117 (5%) Query: 55 LAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVAC 114 A I AM + S L A D +++ D+ T V + S+ + ++P G ++ Sbjct: 543 DAPITAMVYHRSSDLFALALDDLSIVVIDAVTQRVVRQLWGHSNRITAFDFSPEGRWIVS 602 Query: 115 GGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGD--TTCALW 169 LD+ ++L T + + + +F + ++ ++ +W Sbjct: 603 ASLDSTIRTWDLPTGGCIDGIIVDNVA-----TNVKFSPNGDLLATTHVTGNGICIW 654 >5XYI-g nrPDB Length = 335 Score = 154 bits (388), Expect = 6e-38, Method: Composition-based stats. Identities = 57/316 (18%), Positives = 116/316 (36%), Gaps = 33/316 (10%) Query: 48 RRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTN-----KVHAIPLRSSWVMT 102 R T GH A I ++ + LVSAS+D ++W T + + +V Sbjct: 26 RATFVGHNAAIESIEIDNEHNYLVSASRDKSALVWKLNRTQEQWATPFTRLIGHNHFVSD 85 Query: 103 CAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLD-DNQIVTSS 161 + + +++ D+ +++L TR + GH + F + +I++ Sbjct: 86 VSLSRDASHLLTSSWDSTLRLWDLSTRT----TKKLFLGHKKDVLGVTFSPCNRRIISVG 141 Query: 162 GDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTR-----LFVSGACDASAKLWDVR-E 215 D +W+I G+ + V S++ AP + G D +W + E Sbjct: 142 RDNQVKIWNIL-GENKAELQC-SSWVTSVACAPMADETSPLVIAVGCWDGKVYIWSIEKE 199 Query: 216 GMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITS 275 + F H+ ++ F P+G TG D ++ + ++++ + + Sbjct: 200 AKLIKEFKAHDGRCTSVDFTPDGKWVITGGSDRKVVMWLTENGAKTISFTA---PSPVHA 256 Query: 276 VSFSKSGRLLLAGYDDFNCNVWDALKADRAGVL-----------AGHDNRVSCLGVTDDG 324 V+ + + A + VWD + ++ AG +CL DG Sbjct: 257 VAACPTQAWICAATYEG-IAVWDIGAKQQIDLVQPNFKHEGKRNAGRTPDCTCLAWAADG 315 Query: 325 MAVATGSWDSFLKIWN 340 + +G D ++ W Sbjct: 316 SVLYSGYNDGSIRAWE 331 Score = 149 bits (377), Expect = 1e-36, Method: Composition-based stats. Identities = 51/265 (19%), Positives = 97/265 (36%), Gaps = 14/265 (5%) Query: 49 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPS 108 L GH + + D+ L+++S D L +WD T V+ ++P Sbjct: 74 TRLIGHNHFVSDVSLSRDASHLLTSSWDSTLRLWDLSTRTTKKLFLGHKKDVLGVTFSPC 133 Query: 109 GNYVACGGLDNICSIYNLKT-REGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCA 167 + G DN I+N+ + ++ S + I D Sbjct: 134 NRRIISVGRDNQVKIWNILGENKAELQCSSWVTSVACAPMADETSP-LVIAVGCWDGKVY 192 Query: 168 LWDIE-TGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHE 226 +W IE + F H G S+ PD + ++G D +W G +FT Sbjct: 193 IWSIEKEAKLIKEFKAHDGRCTSVDFTPDGKWVITGGSDRKVVMWLTENGAKTISFTA-P 251 Query: 227 SDINAICFFPNGNAFATGSDDATCRLFDLRADQEL----MTYSHDNI-----ICGITSVS 277 S ++A+ P + + ++D+ A Q++ + H+ T ++ Sbjct: 252 SPVHAVAACPTQAWICAATYEG-IAVWDIGAKQQIDLVQPNFKHEGKRNAGRTPDCTCLA 310 Query: 278 FSKSGRLLLAGYDDFNCNVWDALKA 302 ++ G +L +GY+D + W+ A Sbjct: 311 WAADGSVLYSGYNDGSIRAWEVKSA 335 Score = 137 bits (344), Expect = 9e-33, Method: Composition-based stats. Identities = 46/221 (20%), Positives = 88/221 (39%), Gaps = 16/221 (7%) Query: 131 GNVRVSRELAGHTGYLSCCRFLDD-NQIVTSSGDTTCALWDIETGQ-----QTTTFTGHT 184 + GH + ++ N +V++S D + +W + Q T GH Sbjct: 21 AHFAPRATFVGHNAAIESIEIDNEHNYLVSASRDKSALVWKLNRTQEQWATPFTRLIGHN 80 Query: 185 GDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATG 244 V +SL+ D ++ + D++ +LWD+ ++ F GH+ D+ + F P + Sbjct: 81 HFVSDVSLSRDASHLLTSSWDSTLRLWDLSTRTTKKLFLGHKKDVLGVTFSPCNRRIISV 140 Query: 245 SDDATCRLFDLRADQELMTYSHDNIICGITSVSFSK-----SGRLLLAGYDDFNCNVWDA 299 D +++++ + + +TSV+ + S ++ G D +W Sbjct: 141 GRDNQVKIWNILGENKAEL----QCSSWVTSVACAPMADETSPLVIAVGCWDGKVYIWSI 196 Query: 300 LK-ADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIW 339 K A HD R + + T DG V TG D + +W Sbjct: 197 EKEAKLIKEFKAHDGRCTSVDFTPDGKWVITGGSDRKVVMW 237 Score = 135 bits (339), Expect = 3e-32, Method: Composition-based stats. Identities = 47/235 (20%), Positives = 96/235 (40%), Gaps = 24/235 (10%) Query: 40 VGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSW 99 T++ GH + + + +R ++S +D ++ IW+ NK SSW Sbjct: 107 WDLSTRTTKKLFLGHKKDVLGVTFSPCNRRIISVGRDNQVKIWNILGENKAEL--QCSSW 164 Query: 100 VMTCAYAPSGN-----YVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDD 154 V + A AP + +A G D I+++ E ++ +E H G + F D Sbjct: 165 VTSVACAPMADETSPLVIAVGCWDGKVYIWSI---EKEAKLIKEFKAHDGRCTSVDFTPD 221 Query: 155 NQ-IVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDV 213 + ++T D +W E G +T +FT + V +++ P T+ ++ A +WD+ Sbjct: 222 GKWVITGGSDRKVVMWLTENGAKTISFTAPS-PVHAVAACP-TQAWICAATYEGIAVWDI 279 Query: 214 REGMCRQTFT-----------GHESDINAICFFPNGNAFATGSDDATCRLFDLRA 257 G D + + +G+ +G +D + R +++++ Sbjct: 280 GAKQQIDLVQPNFKHEGKRNAGRTPDCTCLAWAADGSVLYSGYNDGSIRAWEVKS 334 Score = 95.9 bits (237), Expect = 2e-20, Method: Composition-based stats. Identities = 38/173 (21%), Positives = 70/173 (40%), Gaps = 10/173 (5%) Query: 176 QTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVRE-----GMCRQTFTGHESDIN 230 TF GH + S+ + + VS + D SA +W + GH ++ Sbjct: 25 PRATFVGHNAAIESIEIDNEHNYLVSASRDKSALVWKLNRTQEQWATPFTRLIGHNHFVS 84 Query: 231 AICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYD 290 + + + T S D+T RL+DL + + V+FS R +++ Sbjct: 85 DVSLSRDASHLLTSSWDSTLRLWDLSTRTTKKLFL--GHKKDVLGVTFSPCNRRIISVGR 142 Query: 291 DFNCNVWDALKADRAGV-LAGHDNRVSCLGVTDDGM--AVATGSWDSFLKIWN 340 D +W+ L ++A + + V+C + D+ +A G WD + IW+ Sbjct: 143 DNQVKIWNILGENKAELQCSSWVTSVACAPMADETSPLVIAVGCWDGKVYIWS 195 Score = 38.9 bits (89), Expect = 0.003, Method: Composition-based stats. Identities = 12/66 (18%), Positives = 18/66 (27%) Query: 21 ARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLI 80 A ID V + G + W D +L S DG + Sbjct: 269 ATYEGIAVWDIGAKQQIDLVQPNFKHEGKRNAGRTPDCTCLAWAADGSVLYSGYNDGSIR 328 Query: 81 IWDSYT 86 W+ + Sbjct: 329 AWEVKS 334 >6BX3-A nrPDB Length = 314 Score = 154 bits (388), Expect = 7e-38, Method: Composition-based stats. Identities = 61/258 (23%), Positives = 102/258 (39%), Gaps = 23/258 (8%) Query: 101 MTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQ-IVT 159 +P G ++A N IY++ R + + + H S + D Q I T Sbjct: 16 TCAKISPDGQFLAITQGLN-ILIYDINRRTVSQTL---VTSHARPFSELCWSPDGQCIAT 71 Query: 160 SSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCR 219 +S D + + + G TF GHT V+SL+ L + + D S K+WD G Sbjct: 72 ASDDFSVEIIHLSYG-LLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLM 130 Query: 220 QTFTGHESDINAIC-FFPNGNAFATGSDDATCRLFDLRADQELMTYSHD------NIICG 272 +T + H + ++ + + ++GS D R+FD L T ++D N + Sbjct: 131 KTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVP 190 Query: 273 ITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVL------AG--HDNRVSCLGVTDDG 324 I+ V FS++ R LL D +WD + G H + +DG Sbjct: 191 ISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDG 250 Query: 325 MA--VATGSWDSFLKIWN 340 V +G + + WN Sbjct: 251 STPLVISGYENGDIYCWN 268 Score = 137 bits (345), Expect = 6e-33, Method: Composition-based stats. Identities = 55/304 (18%), Positives = 109/304 (35%), Gaps = 31/304 (10%) Query: 59 YAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAI-PLRSSWVMTCAYAPSGNYVACGGL 117 D + L +Q ++I+D + + ++P G +A Sbjct: 16 TCAKISPDGQFLA-ITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASD 74 Query: 118 DNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLD-DNQIVTSSGDTTCALWDIETGQQ 176 D I +L + GHT + F N + TSS D + +WD G Sbjct: 75 DFSVEIIHLSYG-----LLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSL 129 Query: 177 TTTFTGHTGDVMSLSL-APDTRLFVSGACDASAKLWDVREGMCRQTFTGHES-------- 227 T + H+ V+S+ + D+ + SG+ D +++D G C +T T + Sbjct: 130 MKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVV 189 Query: 228 DINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKS------ 281 I+ + F N S D +++D + T+ + G+ S Sbjct: 190 PISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPED 249 Query: 282 --GRLLLAGYDDFNCNVWDALKADRAGVLAG----HDNRVSCLGVTDDGMAVATGSWDSF 335 L+++GY++ + W++ +L G H + V + G + + + + Sbjct: 250 GSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSI--HCFGNIMCSLALNGD 307 Query: 336 LKIW 339 +W Sbjct: 308 CCLW 311 Score = 115 bits (287), Expect = 3e-26, Method: Composition-based stats. Identities = 47/302 (15%), Positives = 99/302 (32%), Gaps = 28/302 (9%) Query: 22 RKACADATLSQITN--NIDPVGRIQMRTRRTL-RGHLAKIYAMHWGTDSRLLVSASQDGK 78 K D IT NI + +TL H + W D + + +AS D Sbjct: 18 AKISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDFS 77 Query: 79 LIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRE 138 + I + +H ++ V++ + GN + +D I++ + + Sbjct: 78 VEI-IHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNG----SLMKT 132 Query: 139 LAGHTGYLSCCRF--LDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGD--------VM 188 ++ H+ + D + + + S D ++D ETG T T + Sbjct: 133 ISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPIS 192 Query: 189 SLSLAPDTRLFVSGACDASAKLWDVREGMCRQTF------TGHESDINAICFFPNGN--- 239 + + + R + + D K+WD G +TF G + F + Sbjct: 193 QVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGST 252 Query: 240 -AFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWD 298 +G ++ ++ L +S G ++ + + +C +W Sbjct: 253 PLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGDCCLWR 312 Query: 299 AL 300 + Sbjct: 313 WV 314 >6CHG-A nrPDB Length = 312 Score = 152 bits (385), Expect = 1e-37, Method: Composition-based stats. Identities = 56/268 (20%), Positives = 107/268 (39%), Gaps = 24/268 (8%) Query: 91 HAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCR 150 +P +C +P G +A ++ +Y + + ++ + H ++C Sbjct: 7 QVLPASGKISTSCQISPDGELIAICQNTDML-VYEISSS----KMMKLTTTHKECINCLC 61 Query: 151 FLDDNQ-IVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAK 209 + D++ I + S D T + I G+ GHT V+S+ + S + D S K Sbjct: 62 WSPDSKCIASGSEDFTVEITHIIYGR-IRRLMGHTAPVISICYNNKGNILCSSSMDESIK 120 Query: 210 LWDVREGMCRQTFTGHESDINAICFFP-NGNAFATGSDDATCRLFDLRADQELMTYSHD- 267 W V G +T + H + +I + + ++GS D R+FD + L T ++D Sbjct: 121 EWHVLSGTALKTMSAHSDAVVSIDIPKFDSSILSSGSYDGLIRIFDTESGHCLKTLTYDK 180 Query: 268 -----NIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGV-LAGHDNRVSCLGVT 321 + + I++V FS++G+ LL D +W+ + L H + L Sbjct: 181 DWIAEDGVVPISTVKFSRNGKFLLVKSLDNVVKLWEYTRGTVVRTFLWPHQETKAKLKYN 240 Query: 322 -------DDGM--AVATGSWDSFLKIWN 340 G V +G+ + +WN Sbjct: 241 CGLELIYPQGKDPLVISGNDSGSMCVWN 268 Score = 146 bits (368), Expect = 2e-35, Method: Composition-based stats. Identities = 47/317 (14%), Positives = 117/317 (36%), Gaps = 31/317 (9%) Query: 6 QLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLR---GHLAKIYAMH 62 Q ++ +I + + D L I N D + ++ + + ++ H I + Sbjct: 3 QFDKQVLPASGKISTSCQISPDGELIAICQNTDML-VYEISSSKMMKLTTTHKECINCLC 61 Query: 63 WGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICS 122 W DS+ + S S+D + I ++ + ++ V++ Y GN + +D Sbjct: 62 WSPDSKCIASGSEDFTVEI-THIIYGRIRRLMGHTAPVISICYNNKGNILCSSSMDESIK 120 Query: 123 IYNLKTREGNVRVSRELAGHTGYLSCCRFL--DDNQIVTSSGDTTCALWDIETGQQTTTF 180 +++ + + ++ H+ + D + + + S D ++D E+G T Sbjct: 121 EWHVLSGTA----LKTMSAHSDAVVSIDIPKFDSSILSSGSYDGLIRIFDTESGHCLKTL 176 Query: 181 TGHTGD--------VMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFT-GHESDINA 231 T + ++ + + + + + D KLW+ G +TF H+ Sbjct: 177 TYDKDWIAEDGVVPISTVKFSRNGKFLLVKSLDNVVKLWEYTRGTVVRTFLWPHQETKAK 236 Query: 232 ICFF-------PNGN--AFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSG 282 + + P G +G+D + ++++ + + + + S+ S S Sbjct: 237 LKYNCGLELIYPQGKDPLVISGNDSGSMCVWNVYSKNLVQKIDEKHRNSPLISI--SASY 294 Query: 283 RLLLAGYDDFNCNVWDA 299 + + CN++ Sbjct: 295 DKVATLSLNGECNLFRV 311 Score = 109 bits (272), Expect = 2e-24, Method: Composition-based stats. Identities = 39/214 (18%), Positives = 86/214 (40%), Gaps = 12/214 (5%) Query: 136 SRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPD 195 + L + C+ D +++ +T +++I + + T H + L +PD Sbjct: 6 KQVLPASGKISTSCQISPDGELIAICQNTDMLVYEISSSKMMKLTTTHKECINCLCWSPD 65 Query: 196 TRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDL 255 ++ SG+ D + ++ + G R+ GH + + +IC+ GN + S D + + + + Sbjct: 66 SKCIASGSEDFTVEITHIIYGRIRR-LMGHTAPVISICYNNKGNILCSSSMDESIKEWHV 124 Query: 256 RADQELMTYSHDNIICGITSVSFSK-SGRLLLAGYDDFNCNVWDALKADRAGVLAGHDN- 313 + L T S + S+ K +L +G D ++D L + Sbjct: 125 LSGTALKTMSA--HSDAVVSIDIPKFDSSILSSGSYDGLIRIFDTESGHCLKTLTYDKDW 182 Query: 314 -------RVSCLGVTDDGMAVATGSWDSFLKIWN 340 +S + + +G + S D+ +K+W Sbjct: 183 IAEDGVVPISTVKFSRNGKFLLVKSLDNVVKLWE 216 >4XYI-A nrPDB Length = 430 Score = 151 bits (382), Expect = 3e-37, Method: Composition-based stats. Identities = 65/284 (22%), Positives = 105/284 (36%), Gaps = 39/284 (13%) Query: 95 LRSSWVMTCAYAPSG-NYVACGGLDNICSIYNLKTREGNVRVS----RELAGHT--GYLS 147 V + P + +A GL+ I++L V L HT G+ Sbjct: 129 HHEGDVNKARFMPQNPDIIATLGLNGNGYIFDLNLYREQPIVQTGHQACLRHHTSEGFGL 188 Query: 148 CCRFLDDNQIVTSSGDTTCALWDIETGQ----------QTTTFTGHTGDVMSLSLA-PDT 196 F+ + + T + DT+ +WDI+ + + HT V L Sbjct: 189 GWNFIQEGTLATGTEDTSICVWDIKGKSLSLEKSIDVAPVSVYHRHTAVVNDLQFHLQHE 248 Query: 197 RLFVSGACDASAKLWDVR---EGMCRQTFTGHESDINAICFFP-NGNAFATGSDDATCRL 252 L S + D + ++ D R Q HE +N + F P N AT S D T L Sbjct: 249 ALLTSVSDDCTLQIHDTRLPSSSSASQCVKAHEQPVNGVAFNPFNDYLLATASADHTVAL 308 Query: 253 FDLRADQELMTYSHDNIICGITSVSFSKS-GRLLLAGYDDFNCNVWDALK---------- 301 +DLR + ++ + + +V +S +L+ D VWD K Sbjct: 309 WDLRRLNQ-RLHTLEGHEDEVYNVQWSPHDEPILVTSSTDRRVCVWDLSKIGEEQTVEDS 367 Query: 302 ----ADRAGVLAGHDNRVSCLGVTDDGMAV-ATGSWDSFLKIWN 340 + + GH NRVS L + V A+ + D+ L+IW+ Sbjct: 368 EDGAPELMFMHGGHTNRVSDLSWNPNNKWVLASLADDNILQIWS 411 Score = 122 bits (305), Expect = 3e-28, Method: Composition-based stats. Identities = 47/285 (16%), Positives = 97/285 (34%), Gaps = 37/285 (12%) Query: 54 HLAKIYAMHWGT-DSRLLVSASQDGKLIIWD---SYTTNKVHA-----IPLRSSWVMTCA 104 H + + + ++ + +G I+D V + +S Sbjct: 130 HEGDVNKARFMPQNPDIIATLGLNGNGYIFDLNLYREQPIVQTGHQACLRHHTSEGFGLG 189 Query: 105 YAPSGN-YVACGGLDNICSIYNLKTRE------GNVRVSRELAGHTGYLSCCRFL--DDN 155 + +A G D ++++K + +V HT ++ +F + Sbjct: 190 WNFIQEGTLATGTEDTSICVWDIKGKSLSLEKSIDVAPVSVYHRHTAVVNDLQFHLQHEA 249 Query: 156 QIVTSSGDTTCALWDIE---TGQQTTTFTGHTGDVMSLSLAP-DTRLFVSGACDASAKLW 211 + + S D T + D + + H V ++ P + L + + D + LW Sbjct: 250 LLTSVSDDCTLQIHDTRLPSSSSASQCVKAHEQPVNGVAFNPFNDYLLATASADHTVALW 309 Query: 212 DVRE-GMCRQTFTGHESDINAICFFP-NGNAFATGSDDATCRLFDLRADQELMTYS---- 265 D+R T GHE ++ + + P + T S D ++DL E T Sbjct: 310 DLRRLNQRLHTLEGHEDEVYNVQWSPHDEPILVTSSTDRRVCVWDLSKIGEEQTVEDSED 369 Query: 266 --------HDNIICGITSVSFSKSGRLLLAG-YDDFNCNVWDALK 301 H ++ +S++ + + +LA DD +W K Sbjct: 370 GAPELMFMHGGHTNRVSDLSWNPNNKWVLASLADDNILQIWSPSK 414 Score = 111 bits (278), Expect = 4e-25, Method: Composition-based stats. Identities = 45/243 (18%), Positives = 93/243 (38%), Gaps = 32/243 (13%) Query: 43 IQMRTRRTLRGHLAKIYAMHWG-TDSRLLVSASQDGKLIIWDSYTTN----------KVH 91 +Q + LR H ++ + + W L + ++D + +WD + V Sbjct: 170 VQTGHQACLRHHTSEGFGLGWNFIQEGTLATGTEDTSICVWDIKGKSLSLEKSIDVAPVS 229 Query: 92 AIPLRSSWVMTCAYAPSGN-YVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCR 150 ++ V + + D I++ + + S+ + H ++ Sbjct: 230 VYHRHTAVVNDLQFHLQHEALLTSVSDDCTLQIHDTRLPSSSSA-SQCVKAHEQPVNGVA 288 Query: 151 FLD--DNQIVTSSGDTTCALWDI-ETGQQTTTFTGHTGDVMSLSLAP-DTRLFVSGACDA 206 F D + T+S D T ALWD+ Q+ T GH +V ++ +P D + V+ + D Sbjct: 289 FNPFNDYLLATASADHTVALWDLRRLNQRLHTLEGHEDEVYNVQWSPHDEPILVTSSTDR 348 Query: 207 SAKLWDVREGMCRQTFT--------------GHESDINAICFFPNGNA-FATGSDDATCR 251 +WD+ + QT GH + ++ + + PN A+ +DD + Sbjct: 349 RVCVWDLSKIGEEQTVEDSEDGAPELMFMHGGHTNRVSDLSWNPNNKWVLASLADDNILQ 408 Query: 252 LFD 254 ++ Sbjct: 409 IWS 411 Score = 61.6 bits (148), Expect = 5e-10, Method: Composition-based stats. Identities = 21/100 (21%), Positives = 42/100 (42%), Gaps = 16/100 (16%) Query: 42 RIQMRTRRTLRGHLAKIYAMHWGT-DSRLLVSASQDGKLIIWDSYTTNKVHAIP------ 94 R + TL GH ++Y + W D +LV++S D ++ +WD + + Sbjct: 312 RRLNQRLHTLEGHEDEVYNVQWSPHDEPILVTSSTDRRVCVWDLSKIGEEQTVEDSEDGA 371 Query: 95 --------LRSSWVMTCAYAPSGNY-VACGGLDNICSIYN 125 ++ V ++ P+ + +A DNI I++ Sbjct: 372 PELMFMHGGHTNRVSDLSWNPNNKWVLASLADDNILQIWS 411 >3ODT-A nrPDB Length = 313 Score = 151 bits (381), Expect = 5e-37, Method: Composition-based stats. Identities = 61/306 (19%), Positives = 118/306 (38%), Gaps = 16/306 (5%) Query: 37 IDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLR 96 IDP Q+ TL+GH + + DS++ S S+DG + +W + Sbjct: 2 IDPFTGYQLS--ATLKGHDQDVRDVVAVDDSKV-ASVSRDGTVRLWSKDDQWLGTVVYTG 58 Query: 97 SSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQ 156 ++ + Y + GG D + + L G + L GH G + F D Sbjct: 59 QGFLNSVCYDSEKELLLFGGKDTMINGVPLFATSGEDPLY-TLIGHQGNVCSLSF-QDGV 116 Query: 157 IVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAP-DTRLFVSGACDASAKLWDVRE 215 +++ S D T +W + G H V + F++ + D + KLW + Sbjct: 117 VISGSWDKTAKVW--KEGSLVYNLQAHNASVWDAKVVSFSENKFLTASADKTIKLW--QN 172 Query: 216 GMCRQTFTG-HESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGIT 274 +TF+G H + + +G F + S+D +L D+ L TY + + Sbjct: 173 DKVIKTFSGIHNDVVRHLAVVDDG-HFISCSNDGLIKLVDMHTGDVLRTY--EGHESFVY 229 Query: 275 SVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDS 334 + +G +++ +D +W V+ + + +G + GS D+ Sbjct: 230 CIKLLPNGD-IVSCGEDRTVRIWSKENGSLKQVITLPAISIWSVDCMSNGDIIV-GSSDN 287 Query: 335 FLKIWN 340 ++I++ Sbjct: 288 LVRIFS 293 >5WBU-D nrPDB Length = 328 Score = 149 bits (377), Expect = 1e-36, Method: Composition-based stats. Identities = 55/293 (18%), Positives = 102/293 (34%), Gaps = 21/293 (7%) Query: 64 GTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSI 123 G+D +L +A D + W +++ + + S V P + +A G + Sbjct: 11 GSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQ-HIRM 69 Query: 124 YNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIV-TSSGDTTCALWDI--ETGQQTTTF 180 Y+L + N +S + G ++ F +D + + T D T +WD+ Q F Sbjct: 70 YDLNSNNPNPIISYD--GVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIF 127 Query: 181 TGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNA 240 + + L P+ + G + +WD++ Q E I + P+ + Sbjct: 128 QV-NAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASY 186 Query: 241 FATGSDDATCRLFDLRA--DQELMTYSHDNIICGIT----SVSFSKSGRLLLAGYDDFNC 294 A + C +++L E+ I T FS LL D C Sbjct: 187 MAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTC 246 Query: 295 NVWDALKADRAGVL------AGHDNR--VSCLGVTDDGMAVATGSWDSFLKIW 339 +W L G +R + + D + T S D+ ++W Sbjct: 247 KIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLW 299 Score = 133 bits (334), Expect = 1e-31, Method: Composition-based stats. Identities = 44/194 (22%), Positives = 77/194 (39%), Gaps = 13/194 (6%) Query: 55 LAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVAC 114 A I + + L+ Q G + IWD T + IP + + P +Y+A Sbjct: 130 NAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAA 189 Query: 115 GGLDNICSIYNLKTREGN----VRVSRELAGHTGYLSCCRFLDDNQIV-TSSGDTTCALW 169 C ++NL G+ + ++ HT Y CRF D+ ++ T S D TC +W Sbjct: 190 VNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIW 249 Query: 170 DIETGQQTTTF--------TGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQT 221 T G + + + D++ V+ + D A+LW V G ++ Sbjct: 250 RTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKRE 309 Query: 222 FTGHESDINAICFF 235 + GH+ + + F Sbjct: 310 YGGHQKAVVCLAFN 323 Score = 103 bits (256), Expect = 1e-22, Method: Composition-based stats. Identities = 30/148 (20%), Positives = 62/148 (41%), Gaps = 4/148 (2%) Query: 195 DTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFD 254 D + + D + + W G+C +T +S +NA+ P+ + A R++D Sbjct: 13 DPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQH-IRMYD 71 Query: 255 LRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKAD--RAGVLAGHD 312 L ++ S+D + I SV F + GR + G +D +WD + + + Sbjct: 72 LNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNA 131 Query: 313 NRVSCLGVTDDGMAVATGSWDSFLKIWN 340 ++C+ + + + G + IW+ Sbjct: 132 P-INCVCLHPNQAELIVGDQSGAIHIWD 158 Score = 100 bits (249), Expect = 9e-22, Method: Composition-based stats. Identities = 35/186 (18%), Positives = 69/186 (37%), Gaps = 4/186 (2%) Query: 157 IVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREG 216 + T+ D T W +G T T V +L + PD + + +++D+ Sbjct: 17 LATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQH-IRMYDLNSN 75 Query: 217 MCRQT--FTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGIT 274 + G +I ++ F +G TG +D T R++DLR+ L + I Sbjct: 76 NPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRN-LQCQRIFQVNAPIN 134 Query: 275 SVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDS 334 V + L+ G ++WD ++ + ++ + D +A + Sbjct: 135 CVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTG 194 Query: 335 FLKIWN 340 +WN Sbjct: 195 NCYVWN 200 Score = 67.8 bits (164), Expect = 7e-12, Method: Composition-based stats. Identities = 29/124 (23%), Positives = 50/124 (40%), Gaps = 20/124 (16%) Query: 39 PVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSS 98 P +I TR L+ + DS LL + S D IW + + + + ++S Sbjct: 214 PKTKIPAHTRYALQ--------CRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSG 265 Query: 99 --------WVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCR 150 W+ CA++ Y+ DN+ ++ ++T E + RE GH + C Sbjct: 266 NPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGE----IKREYGGHQKAVVCLA 321 Query: 151 FLDD 154 F D Sbjct: 322 FNDS 325 Score = 27.3 bits (59), Expect = 9.7, Method: Composition-based stats. Identities = 5/19 (26%), Positives = 10/19 (52%) Query: 322 DDGMAVATGSWDSFLKIWN 340 D + +AT +D ++ W Sbjct: 12 SDPVILATAGYDHTVRFWQ 30 >5CXC-A nrPDB Length = 510 Score = 149 bits (375), Expect = 2e-36, Method: Composition-based stats. Identities = 54/277 (19%), Positives = 99/277 (35%), Gaps = 43/277 (15%) Query: 107 PSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTC 166 P V D + I+N S GHT + +FL +++ ++ D T Sbjct: 156 PGQERVLSASYDGLLRIWNASGSVIATSPSGSHGGHTASIKAAKFLTSDRLASAGMDRTV 215 Query: 167 ALW-----DIETGQQTTTFT--GHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCR 219 +W D TG+ T GHTG V L + ++ ++ + D + W + Sbjct: 216 RVWKYTESDHFTGELKPTLELYGHTGSVDWLDVDGHSKHILTASADGAIGFWSASKASAP 275 Query: 220 QT------------------------------FTGHESDINAICFFPNGNAFA-TGSDDA 248 + ++ H + A F P A + S D Sbjct: 276 EPDASLLPGAHVSKRRKATSSVSTAQRGPLGLWSIHTAPATAAIFDPRDRTVAYSASQDH 335 Query: 249 TCRLFDLRADQELMTYSHDNIICGITSVSFS-KSGRLLLAGYDDFNCNVWDA---LKADR 304 T R DL Q + T + + + +++++ + + LL AG + + D Sbjct: 336 TVRTLDLTTGQVVSTLTLTHPLLSLSALTRAGTTSPLLAAGTSARHITMVDPRASSATTS 395 Query: 305 AGVLAGHDNRVSCLGVTDDGMA-VATGSWDSFLKIWN 340 L GH N+V L + + + +GS D ++W+ Sbjct: 396 VMTLRGHANKVVSLSPSPENEYSLVSGSHDGTCRVWD 432 Score = 101 bits (252), Expect = 4e-22, Method: Composition-based stats. Identities = 64/325 (19%), Positives = 112/325 (34%), Gaps = 55/325 (16%) Query: 53 GHLAKIYAMHWGTDSRLLVSASQDGKLIIW-----DSYTTN--KVHAIPLRSSWVMTCAY 105 GH A I A + T S L SA D + +W D +T + + V Sbjct: 190 GHTASIKAAKFLT-SDRLASAGMDRTVRVWKYTESDHFTGELKPTLELYGHTGSVDWLDV 248 Query: 106 APSGNYVACGGLDNICSIYNLKTREGNVRVSRELAG------------------------ 141 ++ D ++ + L G Sbjct: 249 DGHSKHILTASADGAIGFWSASKASAPEPDASLLPGAHVSKRRKATSSVSTAQRGPLGLW 308 Query: 142 --HTGYLSCCRFLDDNQIV--TSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSL----A 193 HT + F ++ V ++S D T D+ TGQ +T T T ++SLS Sbjct: 309 SIHTAPATAAIFDPRDRTVAYSASQDHTVRTLDLTTGQVVSTLTL-THPLLSLSALTRAG 367 Query: 194 PDTRLFVSGACDASAKLWDVREGMC---RQTFTGHESDINAICFFP-NGNAFATGSDDAT 249 + L +G + D R T GH + + ++ P N + +GS D T Sbjct: 368 TTSPLLAAGTSARHITMVDPRASSATTSVMTLRGHANKVVSLSPSPENEYSLVSGSHDGT 427 Query: 250 CRLFDLRADQELMTYS-----HDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADR 304 CR++DLR+ + + I S++ G+ D C V+ + D+ Sbjct: 428 CRVWDLRSVRPATKEEGSLGGVSEPVYVIERESWASKGKKKRPVAGDG-CKVFSVV-WDK 485 Query: 305 AGVLAGHDNRVSCLGVTDDGMAVAT 329 G+ +G +++ + + G + T Sbjct: 486 LGIFSGGEDKKVQV---NRGRNIVT 507 Score = 50.8 bits (120), Expect = 8e-07, Method: Composition-based stats. Identities = 27/142 (19%), Positives = 44/142 (30%), Gaps = 19/142 (13%) Query: 28 ATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRL-LVSASQDGKLIIWDSYT 86 T ++ +DP + TLRGH K+ ++ ++ LVS S DG +WD + Sbjct: 376 GTSARHITMVDPRASSATTSVMTLRGHANKVVSLSPSPENEYSLVSGSHDGTCRVWDLRS 435 Query: 87 TNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYL 146 V Y A G + R +AG + Sbjct: 436 VRPATKEEGSLGGVSEPVYVIERESWASKG-----------------KKKRPVAGDGCKV 478 Query: 147 SCCRFLDDNQIVTSSGDTTCAL 168 + D I + D + Sbjct: 479 FSVVW-DKLGIFSGGEDKKVQV 499 >4XFV-A nrPDB Length = 792 Score = 148 bits (373), Expect = 4e-36, Method: Composition-based stats. Identities = 59/373 (15%), Positives = 122/373 (32%), Gaps = 73/373 (19%) Query: 38 DPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIW---DSYTTNKVHAIP 94 DP+ TL+GH A++ + + DS +VSAS+D + IW D + I Sbjct: 46 DPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQ 105 Query: 95 LRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGY----LSCCR 150 S ++ + P + ++ G D SI+ + ++ E G+ Sbjct: 106 HYSKTIVALSALP--SLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLS 163 Query: 151 FLDDNQIVTSSGDTTCALW---------DIETGQQTTTFTGHTGDVMSLSL----APDTR 197 +++ + + + G T ++ IE + GH V SL+ P Sbjct: 164 KVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDY 223 Query: 198 LFVSGACDASAKLWDVREGMCR---------------------------------QTFTG 224 L SG+ D +LW +R G Sbjct: 224 LLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMG 283 Query: 225 HESDINAICFFPNGNAFATGSDDATCRLF--DLRADQELMTY-----------SHDNIIC 271 H+ I+++ + + + D + ++ D + + + + Sbjct: 284 HDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSG 343 Query: 272 GITSVSF--SKSGRLLLAGYDDFNCNVW---DALKADRAGVLAGHDNRVSCLGVTDDGMA 326 G S + + L + +W D + D+ ++G V+ + + G Sbjct: 344 GFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEY 403 Query: 327 VATGSWDSFLKIW 339 + S D +++ Sbjct: 404 LLATSLDQTTRLF 416 Score = 102 bits (254), Expect = 2e-22, Method: Composition-based stats. Identities = 48/209 (22%), Positives = 76/209 (36%), Gaps = 26/209 (12%) Query: 155 NQIVTSSGDTTCALWDI---ETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLW 211 +IV T ALWD T GH +V + PD+ VS + D K+W Sbjct: 31 KKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIW 90 Query: 212 ---DVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLF--DLRAD----QELM 262 D C QT + I A+ P + + G D T ++ +++ D Sbjct: 91 KFTDYSHLQCIQTIQHYSKTIVALSALP--SLISVGCADGTISIWRQNIQNDEFGLAHEF 148 Query: 263 TYSHDNIICGITSVSFSKSGRLLLA-GYDDFNCNVWD-------ALKADRAGVLAGHDNR 314 T S+S + + LLA G + N + K L GH++ Sbjct: 149 TIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDW 208 Query: 315 VSCLGV----TDDGMAVATGSWDSFLKIW 339 V L T + +GS D ++++W Sbjct: 209 VKSLAFRHQETPGDYLLCSGSQDRYIRLW 237 Score = 84.7 bits (208), Expect = 5e-17, Method: Composition-based stats. Identities = 40/232 (17%), Positives = 81/232 (34%), Gaps = 27/232 (11%) Query: 51 LRGHLAKIYAMHWGTDSRLLVSASQDGKL-----IIWDSYTTNKVH-AIPLRSSWVMTCA 104 L GH +I + D +L+ SA + + I+ + ++ A+P S + Sbjct: 558 LYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLK 617 Query: 105 YAPSGNYVACGGLDNICSIYNLKTREGNVRV-SRELAGHTGYLSCCRFLD---DNQIVTS 160 ++ G ++ D +++ + + + HT + + N VT+ Sbjct: 618 FSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTA 677 Query: 161 SGDTTCALWDIETGQ----QTTTFTGHTGDVMSLSLAPD---TRLFVSGA-CDASAKLWD 212 S D T +W + HT V ++S+ ++ +S + L+ Sbjct: 678 SRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIYLYS 737 Query: 213 VREGMCRQTFTGHE-----SDINAICFF---PNGNAFA-TGSDDATCRLFDL 255 G +E I + + NG F GS D + R++ L Sbjct: 738 YTLGKFELITQLNEDITPADKITRLRWSHLKRNGKLFLGVGSSDLSTRIYSL 789 Score = 68.6 bits (166), Expect = 4e-12, Method: Composition-based stats. Identities = 57/384 (14%), Positives = 113/384 (29%), Gaps = 88/384 (22%) Query: 8 RQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDS 67 R L + + K + Q ID R+ + + GH I ++ W Sbjct: 238 RIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESR 297 Query: 68 RLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLK 127 L++A+ D L++W+ T+ + WV + + A + + Sbjct: 298 LQLLAATADTSLMVWEPDETSGI--------WVCSLRLGEMSSKGASTATGSSGGFW--- 346 Query: 128 TREGNVRVSRELAGHTGYLSCCRFLDDNQ--IVTSSGDTTCALW---DIETGQQTTTFTG 182 SC F + +T+ + +W D Q +G Sbjct: 347 -------------------SCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISG 387 Query: 183 HTGDVMSLSLAPDTRLFVSGACDASAK-----LWDVRE-GMCRQTF------TGHESDIN 230 T DV ++ +P ++ + D + + ++D T+ H D+ Sbjct: 388 ATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMI 447 Query: 231 AICFFPNGNAFATGSDDATCRLFDLRADQ----------ELMTYSHDNIICGITSVSFS- 279 + + F +G D+ R FDL + S + + S Sbjct: 448 CVETVTD-TRFVSGGDEKILRSFDLPKGVAGMLQKFVGIQFEEKSEMPDSATVPVLGLSN 506 Query: 280 ------------------------KSGRLLLAG--YDDFNCNVWDALKADRAGVLAGHDN 313 LL +D L + L GH Sbjct: 507 KAGEDDANEDDEEEEGGNKETPDITDPLSLLECPPMEDQLQR--HLLWPE-VEKLYGHGF 563 Query: 314 RVSCLGVTDDGMAVATGSWDSFLK 337 ++CL ++ D +A+ + ++ Sbjct: 564 EITCLDISPDQKLIASACRSNNVQ 587 Score = 67.0 bits (162), Expect = 1e-11, Method: Composition-based stats. Identities = 27/133 (20%), Positives = 44/133 (33%), Gaps = 13/133 (9%) Query: 219 RQTFTGHESDINAICFFPNGNAFATGSDDA-----TCRLFDLRADQELMTYSHDNIICGI 273 + GH +I + P+ A+ R+F E+ + + I Sbjct: 555 VEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLT-I 613 Query: 274 TSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVL-----AGHDNRVSCLGVTD--DGMA 326 T + FSK G+ LL+ D +W+ D L H + G Sbjct: 614 TRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNV 673 Query: 327 VATGSWDSFLKIW 339 T S D +K+W Sbjct: 674 FVTASRDKTVKVW 686 Score = 65.9 bits (159), Expect = 2e-11, Method: Composition-based stats. Identities = 25/161 (15%), Positives = 51/161 (31%), Gaps = 15/161 (9%) Query: 176 QTTTFTGHTGDVMSLSLAPDTRLFVSGA-----CDASAKLWDVRE-GMCRQTFTGHESDI 229 + GH ++ L ++PD +L S +A +++ + H I Sbjct: 554 EVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTI 613 Query: 230 NAICFFPNGNAFATGSDDATCRLFDLRADQ---ELMTYSHDNIICGITSVSFSKS--GRL 284 + F +G + D L++ + EL + I ++ G + Sbjct: 614 TRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNV 673 Query: 285 LLAGYDDFNCNVW-DALKADRAGVLAG---HDNRVSCLGVT 321 + D VW + VL H V+ + + Sbjct: 674 FVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIH 714 Score = 59.7 bits (143), Expect = 2e-09, Method: Composition-based stats. Identities = 27/190 (14%), Positives = 64/190 (33%), Gaps = 21/190 (11%) Query: 45 MRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAI-----PLRSSW 99 + + L H I + + D + L+S +D K +W+ + + + Sbjct: 600 LEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRI 659 Query: 100 VMTCAYAPS--GNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLD---- 153 + +AP GN D ++ + + V HT ++ D Sbjct: 660 IWDADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIR 719 Query: 154 DNQIVTSSGDTT-CALWDIETGQ-----QTTTFTGHTGDVMSLSLA---PDTRLFV-SGA 203 + +++ + L+ G+ Q + L + + +LF+ G+ Sbjct: 720 EKILISVGLENGEIYLYSYTLGKFELITQLNEDITPADKITRLRWSHLKRNGKLFLGVGS 779 Query: 204 CDASAKLWDV 213 D S +++ + Sbjct: 780 SDLSTRIYSL 789 Score = 58.2 bits (139), Expect = 5e-09, Method: Composition-based stats. Identities = 14/61 (22%), Positives = 27/61 (44%), Gaps = 3/61 (4%) Query: 283 RLLLAGYDDFNCNVWDALKADR---AGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIW 339 + ++A +WD ++ + L GH+ V+C+ D + + S D +KIW Sbjct: 31 KKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIW 90 Query: 340 N 340 Sbjct: 91 K 91 >5K0Y-T nrPDB Length = 329 Score = 144 bits (363), Expect = 5e-35, Method: Composition-based stats. Identities = 46/212 (21%), Positives = 88/212 (41%), Gaps = 11/212 (5%) Query: 139 LAGHTGYLSCCRFLDDNQIV-TSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTR 197 L GH ++ ++ + ++ T + D +W G++ T+ GHTG V + DT+ Sbjct: 6 LQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTK 65 Query: 198 LFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDAT-----CRL 252 ++G+ D S +LWD G S + F GN +D Sbjct: 66 HVLTGSADNSCRLWDCETGKQLALLKT-NSAVRTCGFDFGGNIIMFSTDKQMGYQCFVSF 124 Query: 253 FDLRADQEL-MTYSHDNIICG---ITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVL 308 FDLR ++ + I C ITS + G ++AG++ N + A + + Sbjct: 125 FDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGEVLVNV 184 Query: 309 AGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 H +++ + ++ + T S D+ K+++ Sbjct: 185 KEHSRQINDIQLSREMTMFVTASKDNTAKLFD 216 Score = 127 bits (318), Expect = 1e-29, Method: Composition-based stats. Identities = 51/314 (16%), Positives = 104/314 (33%), Gaps = 34/314 (10%) Query: 51 LRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGN 110 L+GH I + + + LL + ++D + +W S ++ + V Sbjct: 6 LQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTK 65 Query: 111 YVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTT----- 165 +V G DN C +++ +T + + + + + + C F I+ S D Sbjct: 66 HVLTGSADNSCRLWDCETGK-QLALLKTNSA----VRTCGFDFGGNIIMFSTDKQMGYQC 120 Query: 166 -CALWDIETGQQTTT------FTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMC 218 + +D+ Q + + S P ++G + + G Sbjct: 121 FVSFFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGEV 180 Query: 219 RQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSF 278 H IN I F T S D T +LFD + T+ + + Sbjct: 181 LVNVKEHSRQINDIQLSREMTMFVTASKDNTAKLFDSTTLEHQKTFRTEP---PRELAAL 237 Query: 279 SKSGRLLLAGY--------------DDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDG 324 S + ++ G F + + G + GH ++ + DG Sbjct: 238 SPNYEHVVVGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHPDG 297 Query: 325 MAVATGSWDSFLKI 338 + ++G D +++I Sbjct: 298 KSYSSGGEDGYVRI 311 Score = 109 bits (273), Expect = 1e-24, Method: Composition-based stats. Identities = 49/282 (17%), Positives = 101/282 (35%), Gaps = 26/282 (9%) Query: 37 IDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLR 96 ++ + T GH ++ + D++ +++ S D +WD T ++ + Sbjct: 34 VNVWYSVNGERLGTYMGHTGAVWCVDADWDTKHVLTGSADNSCRLWDCETGKQLALLKTN 93 Query: 97 SSWVMTCAYAPSGNYVACG-----GLDNICSIYNLK--TREGNVRVSRELAGHTGYLSCC 149 S V TC + GN + G S ++L+ ++ N ++ + ++ Sbjct: 94 -SAVRTCGFDFGGNIIMFSTDKQMGYQCFVSFFDLRDPSQIDNNEPYMKIPCNDSKITSA 152 Query: 150 RFLD-DNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASA 208 + I+ + ++G+ H+ + + L+ + +FV+ + D +A Sbjct: 153 VWGPLGECIIAGHESGELNQYSAKSGEVLVNVKEHSRQINDIQLSREMTMFVTASKDNTA 212 Query: 209 KLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGS----DDAT----------CRLFD 254 KL+D ++TF E PN G D T R F Sbjct: 213 KLFDSTTLEHQKTFRT-EPPRELAALSPNYEHVVVGGGQEAMDVTTTSTRIGKFEARFFH 271 Query: 255 LRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNV 296 L ++E I SV+F G+ +G +D + Sbjct: 272 LAFEEEFGRV--KGHFGPINSVAFHPDGKSYSSGGEDGYVRI 311 Score = 33.9 bits (76), Expect = 0.11, Method: Composition-based stats. Identities = 9/49 (18%), Positives = 16/49 (32%) Query: 93 IPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAG 141 + + + A+ P G + GG D I+ + AG Sbjct: 281 VKGHFGPINSVAFHPDGKSYSSGGEDGYVRIHYFDPQYFEFEFEAREAG 329 >5WLC-LU nrPDB Length = 489 Score = 144 bits (363), Expect = 5e-35, Method: Composition-based stats. Identities = 46/290 (15%), Positives = 100/290 (34%), Gaps = 41/290 (14%) Query: 50 TLRGHLAKIYAMHWGTD-----------SRLLVSASQDGKLIIWDSYTTNK--------- 89 + + H + + ++S S D + +W + Sbjct: 105 SFKAHYGLVTGLCVTQPRFHDKKPDLKSQNFMLSCSDDKTVKLWSINVDDYSNKNSSDND 164 Query: 90 --------VHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAG 141 + S++ + A GG ++++ ++ +L+ Sbjct: 165 SVTNEEGLIRTFDGESAF-QGIDSHRENSTFATGGA--KIHLWDVN----RLKPVSDLSW 217 Query: 142 HTGYLSCCRFLDDNQ--IVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRL- 198 ++ +F + + ++ D + L+D+ T T T ++ P Sbjct: 218 GADNITSLKFNQNETDILASTGSDNSIVLYDLRTNSPTQKIV-QTMRTNAICWNPMEAFN 276 Query: 199 FVSGACDASAKLWDVRE-GMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRA 257 FV+ D +A +D+R F H S + + F P G+ TGS D + R++ Sbjct: 277 FVTANEDHNAYYYDMRNLSRSLNVFKDHVSAVMDVDFSPTGDEIVTGSYDKSIRIYKTNH 336 Query: 258 DQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGV 307 Y H + + V +S + +++G DD N +W + +R+ V Sbjct: 337 GHSREIY-HTKRMQHVFQVKYSMDSKYIISGSDDGNVRLWRSKAWERSNV 385 Score = 129 bits (324), Expect = 2e-30, Method: Composition-based stats. Identities = 55/275 (20%), Positives = 95/275 (34%), Gaps = 35/275 (12%) Query: 95 LRSSWVMTCAYA-PSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTG-YLSCCRFL 152 V A S N +A G D + +N+ TRE V TG ++ RF Sbjct: 65 GHRDGVYAIAKNYGSLNKLATGSADGVIKYWNMSTREEFVSFKAHYGLVTGLCVTQPRFH 124 Query: 153 DD-------NQIVTSSGDTTCALW---------------DIETGQQ--TTTFTGHTGDVM 188 D N +++ S D T LW D T ++ TF G + Sbjct: 125 DKKPDLKSQNFMLSCSDDKTVKLWSINVDDYSNKNSSDNDSVTNEEGLIRTFDGESAF-Q 183 Query: 189 SLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNG-NAFATGSDD 247 + + F +G LWDV + +I ++ F N + A+ D Sbjct: 184 GIDSHRENSTFATGGA--KIHLWDVNRLKPVSDLSWGADNITSLKFNQNETDILASTGSD 241 Query: 248 ATCRLFDLRADQELMTYSHDNIICGITSVSFSK-SGRLLLAGYDDFNCNVWDALK-ADRA 305 + L+DLR + ++ ++ + +D N +D + Sbjct: 242 NSIVLYDLRTNSPTQKIV---QTMRTNAICWNPMEAFNFVTANEDHNAYYYDMRNLSRSL 298 Query: 306 GVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 V H + V + + G + TGS+D ++I+ Sbjct: 299 NVFKDHVSAVMDVDFSPTGDEIVTGSYDKSIRIYK 333 Score = 58.2 bits (139), Expect = 5e-09, Method: Composition-based stats. Identities = 18/99 (18%), Positives = 38/99 (38%), Gaps = 2/99 (2%) Query: 42 RIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRS-SWV 100 R R+ + H++ + + + +V+ S D + I+ + + + V Sbjct: 292 RNLSRSLNVFKDHVSAVMDVDFSPTGDEIVTGSYDKSIRIYKTNHGHSREIYHTKRMQHV 351 Query: 101 MTCAYAPSGNYVACGGLDNICSIYNLKTRE-GNVRVSRE 138 Y+ Y+ G D ++ K E NV+ +RE Sbjct: 352 FQVKYSMDSKYIISGSDDGNVRLWRSKAWERSNVKTTRE 390 >3JRO-A nrPDB Length = 753 Score = 142 bits (357), Expect = 3e-34, Method: Composition-based stats. Identities = 50/277 (18%), Positives = 95/277 (34%), Gaps = 34/277 (12%) Query: 53 GHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSY--TTNKVHAIPLRSSWVMTCAYAPS-- 108 H I+ + L + S D + I++ T + + V +A Sbjct: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKF 66 Query: 109 GNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLD---DNQIVTSSGDTT 165 G +A D I+ K G A H+ ++ ++ ++ +S D Sbjct: 67 GTILASCSYDGKVLIW--KEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGK 124 Query: 166 CALWDIETGQQTT--TFTGHTGDVMSLSLAP-------------DTRLFVSGACDASAKL 210 ++ + + T+ H V S S AP ++R FV+G D K+ Sbjct: 125 VSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKI 184 Query: 211 W----DVREGMCRQTFTGHESDINAICFFPN---GNAFATGSDDATCRLF---DLRADQE 260 W D + + T GH + + + P + A+ S D TC ++ + + + Sbjct: 185 WKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWK 244 Query: 261 LMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVW 297 + + S+S SG +L D +W Sbjct: 245 KTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 Score = 130 bits (326), Expect = 1e-30, Method: Composition-based stats. Identities = 44/240 (18%), Positives = 82/240 (34%), Gaps = 34/240 (14%) Query: 46 RTRRTLRGHLAKIYAMHWGTD--SRLLVSASQDGKLIIWDSYTTN--KVHAIPLRSSWVM 101 + TL GH ++ + W +L S S DGK++IW ++ + S+ V Sbjct: 44 KLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVN 103 Query: 102 TCAYAPS--GNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLD------ 153 + +AP G + D S+ K + + H ++ + Sbjct: 104 SVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPII--IDAHAIGVNSASWAPATIEED 161 Query: 154 --------DNQIVTSSGDTTCALW----DIETGQQTTTFTGHTGDVMSLSLAPD---TRL 198 + VT D +W D +T +T GH+ V ++ +P Sbjct: 162 GEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSY 221 Query: 199 FVSGACDASAKLW--DVREGMCRQTF---TGHESDINAICFFPNGNAFATGSDDATCRLF 253 S + D + +W D +G ++T + + +GN A D L+ Sbjct: 222 LASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 Score = 129 bits (323), Expect = 2e-30, Method: Composition-based stats. Identities = 43/214 (20%), Positives = 74/214 (34%), Gaps = 28/214 (13%) Query: 154 DNQIVTSSGDTTCALWDIE--TGQQTTTFTGHTGDVMSLSL-APD-TRLFVSGACDASAK 209 ++ T S D T ++++E T + T TGH G V + P + S + D Sbjct: 21 GKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVL 80 Query: 210 LWDVREGMCRQTFTG--HESDINAICFFPN--GNAFATGSDDATCRLFDLRADQELMTYS 265 +W G Q H + +N++ + P+ G S D + + + + Sbjct: 81 IWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPII 140 Query: 266 HDNIICGITSVSFSK-------------SGRLLLAGYDDFNCNVW----DALKADRAGVL 308 D G+ S S++ R + G D +W DA L Sbjct: 141 IDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTL 200 Query: 309 AGHDNRVSCLGVTDDG---MAVATGSWDSFLKIW 339 GH + V + + +A+ S D IW Sbjct: 201 EGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIW 234 Score = 119 bits (299), Expect = 1e-27, Method: Composition-based stats. Identities = 42/278 (15%), Positives = 86/278 (30%), Gaps = 34/278 (12%) Query: 95 LRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLD- 153 + + G +A D I+ ++ ++ L GH G + + Sbjct: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEG--ETHKLIDTLTGHEGPVWRVDWAHP 64 Query: 154 --DNQIVTSSGDTTCALWDIETGQ--QTTTFTGHTGDVMSLSLAPD--TRLFVSGACDAS 207 + + S D +W E G+ Q H+ V S+ AP L + + D Sbjct: 65 KFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGK 124 Query: 208 AKLWDVREG--MCRQTFTGHESDINAICFFP-------------NGNAFATGSDDATCRL 252 + + +E H +N+ + P F TG D ++ Sbjct: 125 VSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKI 184 Query: 253 FDLRADQELMTYSH--DNIICGITSVSFSKS---GRLLLAGYDDFNCNVW--DALKADRA 305 + +D + + + V++S + L + D C +W D + Sbjct: 185 WKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWK 244 Query: 306 GVLAGHDNR---VSCLGVTDDGMAVATGSWDSFLKIWN 340 L + + + G +A D+ + +W Sbjct: 245 KTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 282 Score = 98.2 bits (243), Expect = 4e-21, Method: Composition-based stats. Identities = 32/181 (17%), Positives = 59/181 (32%), Gaps = 21/181 (11%) Query: 181 TGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVR--EGMCRQTFTGHESDINAICF-FPN 237 H + L + + + D + K+++V T TGHE + + + P Sbjct: 6 NAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPK 65 Query: 238 -GNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKS--GRLLLAGYDDFNC 294 G A+ S D ++ + H + SV ++ G LLL D Sbjct: 66 FGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKV 125 Query: 295 NVWDALKADRAG--VLAGHDNRVSCLGVTD-------------DGMAVATGSWDSFLKIW 339 +V + + ++ H V+ + TG D+ +KIW Sbjct: 126 SVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIW 185 Query: 340 N 340 Sbjct: 186 K 186 Score = 58.9 bits (141), Expect = 3e-09, Method: Composition-based stats. Identities = 28/138 (20%), Positives = 49/138 (35%), Gaps = 9/138 (6%) Query: 10 EAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTD--- 66 E + N +++RK + + TL GH + + W Sbjct: 159 EEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLL 218 Query: 67 SRLLVSASQDGKLIIW--DSYTTNKVHAIPLRSSWV---MTCAYAPSGNYVACGGLDNIC 121 L S SQD IIW D+ + + +++ SGN +A G DN Sbjct: 219 RSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKV 278 Query: 122 SIYNLKTREGNVRVSREL 139 +++ + EG + E+ Sbjct: 279 TLWK-ENLEGKWEPAGEV 295 >4U1E-I nrPDB Length = 347 Score = 141 bits (355), Expect = 4e-34, Method: Composition-based stats. Identities = 52/213 (24%), Positives = 94/213 (44%), Gaps = 19/213 (8%) Query: 139 LAGHTGYLSCCRFLDDNQIV-TSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTR 197 L GH L+ ++ + ++ + S D++ ++W G++ T GHTG + S+ + T+ Sbjct: 6 LTGHERPLTQVKYNKEGDLLFSCSKDSSASVWYSLNGERLGTLDGHTGTIWSIDVDCFTK 65 Query: 198 LFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDD-----ATCRL 252 V+G+ D S KLWDV G C T+ + + F P GN F D+ + + Sbjct: 66 YCVTGSADYSIKLWDVSNGQCVATWKS-PVPVKRVEFSPCGNYFLAILDNVMKNPGSINI 124 Query: 253 FDLRAD---QELMTYSHDNIICGITS--------VSFSKSGRLLLAGYDDFNCNVWDAL- 300 +++ D EL S + I IT +S G+ ++AG+ D + +D Sbjct: 125 YEIERDSATHELTKVSEEPIHKIITHEGLDAATVAGWSTKGKYIIAGHKDGKISKYDVSN 184 Query: 301 KADRAGVLAGHDNRVSCLGVTDDGMAVATGSWD 333 + + H+ +S + + D T S D Sbjct: 185 NYEYVDSIDLHEKSISDMQFSPDLTYFITSSRD 217 Score = 127 bits (318), Expect = 9e-30, Method: Composition-based stats. Identities = 50/322 (15%), Positives = 108/322 (33%), Gaps = 42/322 (13%) Query: 51 LRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGN 110 L GH + + + + LL S S+D +W S ++ + + + + Sbjct: 6 LTGHERPLTQVKYNKEGDLLFSCSKDSSASVWYSLNGERLGTLDGHTGTIWSIDVDCFTK 65 Query: 111 YVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDT------ 164 Y G D ++++ + + + F + D Sbjct: 66 YCVTGSADYSIKLWDVSNGQCVATWKSPV-----PVKRVEFSPCGNYFLAILDNVMKNPG 120 Query: 165 TCALWDIE-----------TGQQTTTFTGHTG-DVMSLS-LAPDTRLFVSGACDASAKLW 211 + +++IE + + H G D +++ + + ++G D + Sbjct: 121 SINIYEIERDSATHELTKVSEEPIHKIITHEGLDAATVAGWSTKGKYIIAGHKDGKISKY 180 Query: 212 DVREG-MCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNII 270 DV + HE I+ + F P+ F T S D L D+ Q L Y D Sbjct: 181 DVSNNYEYVDSIDLHEKSISDMQFSPDLTYFITSSRDTNSFLVDVSTLQVLKKYETD--- 237 Query: 271 CGITSVSFSKSGRLLLAGY--------------DDFNCNVWDALKADRAGVLAGHDNRVS 316 C + + + ++ G F + + + G + GH ++ Sbjct: 238 CPLNTAVITPLKEFIILGGGQEAKDVTTTSANEGKFEARFYHKIFEEEIGRVQGHFGPLN 297 Query: 317 CLGVTDDGMAVATGSWDSFLKI 338 + ++ G + A+G D F+++ Sbjct: 298 TVAISPQGTSYASGGEDGFIRL 319 Score = 67.4 bits (163), Expect = 9e-12, Method: Composition-based stats. Identities = 22/80 (27%), Positives = 36/80 (45%) Query: 261 LMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGV 320 + +T V ++K G LL + D + +VW +L +R G L GH + + V Sbjct: 1 MKAIKLTGHERPLTQVKYNKEGDLLFSCSKDSSASVWYSLNGERLGTLDGHTGTIWSIDV 60 Query: 321 TDDGMAVATGSWDSFLKIWN 340 TGS D +K+W+ Sbjct: 61 DCFTKYCVTGSADYSIKLWD 80 Score = 61.2 bits (147), Expect = 5e-10, Method: Composition-based stats. Identities = 30/197 (15%), Positives = 69/197 (35%), Gaps = 12/197 (6%) Query: 26 ADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSY 85 + T+ + V + T G L W T + +++ +DGK+ +D Sbjct: 125 YEIERDSATHELTKVSEEPIHKIITHEG-LDAATVAGWSTKGKYIIAGHKDGKISKYDVS 183 Query: 86 TT-NKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTG 144 V +I L + ++P Y D + ++ T + + + +T Sbjct: 184 NNYEYVDSIDLHEKSISDMQFSPDLTYFITSSRDTNSFLVDVSTLQVLKKYETDCPLNTA 243 Query: 145 YLSCCRFL-------DDNQIVTSS---GDTTCALWDIETGQQTTTFTGHTGDVMSLSLAP 194 ++ + + + T+S G + ++ GH G + +++++P Sbjct: 244 VITPLKEFIILGGGQEAKDVTTTSANEGKFEARFYHKIFEEEIGRVQGHFGPLNTVAISP 303 Query: 195 DTRLFVSGACDASAKLW 211 + SG D +L Sbjct: 304 QGTSYASGGEDGFIRLH 320 >5OQL-L nrPDB Length = 557 Score = 139 bits (351), Expect = 1e-33, Method: Composition-based stats. Identities = 59/277 (21%), Positives = 107/277 (38%), Gaps = 19/277 (6%) Query: 65 TDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIY 124 T+ V+A ++ I+ + I S P G + G ++ Sbjct: 69 TNDLFAVTAGP--RVEIFSIRKREPLKTIGRFDSEAHCGEIRPDGRVLVAGEDTGRMQVF 126 Query: 125 NLKTREGNVRVSRELAGHTGYLSCCRFLDD--NQIVTSSGDTTCALWDIETGQQTTTFTG 182 ++ V + + H + ++ +++ S D T LWD+ + T FTG Sbjct: 127 DVGQGTRAV-ILKTWHIHKQPVWVTKWSPTELTTLMSCSDDKTVRLWDLPSNDPTRLFTG 185 Query: 183 HTGDVMSLSLAP---DTRLFVSGACDASAKLWDVR-EGMCRQTFTGHESDINAICFFPNG 238 HT V + P ++ L VSG+ D + ++WD R G TF H I + P+G Sbjct: 186 HTDYVRCGAFMPGSANSNLLVSGSYDETVRVWDARAPGGAVMTFK-HADPIEDVLPLPSG 244 Query: 239 NAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWD 298 S + DL A + L + N +TS+S + GR +++G D + V++ Sbjct: 245 TTLLAASG-NAISVLDLVAAKPLRLIT--NHQKTVTSLSLASQGRRVVSGSLDGHVKVFE 301 Query: 299 ALKADRAGVLAGHDNRVSCLGV-----TDDGMAVATG 330 + + + + L V + D +A G Sbjct: 302 TTSWNVVAGAK-YPSPILSLSVITAGASHDDRHLAVG 337 Score = 133 bits (335), Expect = 9e-32, Method: Composition-based stats. Identities = 59/248 (23%), Positives = 102/248 (41%), Gaps = 20/248 (8%) Query: 103 CAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSR-ELAGHTGYLSCCRFLDDNQIVTSS 161 A A + + A I++++ RE + R + H G + D +++ + Sbjct: 64 VAAAKTNDLFAVTAGPR-VEIFSIRKREPLKTIGRFDSEAHCGEIR-----PDGRVLVAG 117 Query: 162 GDT-TCALWDIETGQQTTTFTG---HTGDVMSLSLAPDT-RLFVSGACDASAKLWDVREG 216 DT ++D+ G + H V +P +S + D + +LWD+ Sbjct: 118 EDTGRMQVFDVGQGTRAVILKTWHIHKQPVWVTKWSPTELTTLMSCSDDKTVRLWDLPSN 177 Query: 217 MCRQTFTGHESDINAICFFP---NGNAFATGSDDATCRLFDLRA-DQELMTYSHDNIICG 272 + FTGH + F P N N +GS D T R++D RA +MT+ H + I Sbjct: 178 DPTRLFTGHTDYVRCGAFMPGSANSNLLVSGSYDETVRVWDARAPGGAVMTFKHADPIED 237 Query: 273 ITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSW 332 + + SG LLA +V D + A ++ H V+ L + G V +GS Sbjct: 238 VLPL---PSGTTLLAASG-NAISVLDLVAAKPLRLITNHQKTVTSLSLASQGRRVVSGSL 293 Query: 333 DSFLKIWN 340 D +K++ Sbjct: 294 DGHVKVFE 301 Score = 122 bits (307), Expect = 2e-28, Method: Composition-based stats. Identities = 49/285 (17%), Positives = 103/285 (36%), Gaps = 22/285 (7%) Query: 21 ARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLI 80 A D ++ + +T+ ++ + D R+LV+ G++ Sbjct: 65 AAAKTNDLFAVTAGPRVEIFSIRKREPLKTIGRFDSEAHCGEIRPDGRVLVAGEDTGRMQ 124 Query: 81 IWDSYTTN---KVHAIPLRSSWVMTCAYAP-SGNYVACGGLDNICSIYNLKTREGNVRVS 136 ++D + + V ++P + D +++L + + + Sbjct: 125 VFDVGQGTRAVILKTWHIHKQPVWVTKWSPTELTTLMSCSDDKTVRLWDLPSNDP----T 180 Query: 137 RELAGHTGYLSCCRFLDD----NQIVTSSGDTTCALWDIET-GQQTTTFTGHTGDVMSLS 191 R GHT Y+ C F+ N +V+ S D T +WD G TF H + + Sbjct: 181 RLFTGHTDYVRCGAFMPGSANSNLLVSGSYDETVRVWDARAPGGAVMTFK-HADPIEDVL 239 Query: 192 LAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCR 251 P ++ + +A + D+ + T H+ + ++ G +GS D + Sbjct: 240 PLPSGTTLLAASGNA-ISVLDLVAAKPLRLITNHQKTVTSLSLASQGRRVVSGSLDGHVK 298 Query: 252 LFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNV 296 +F+ + + + I S+S +G A +DD + V Sbjct: 299 VFETTSWNVVAGAKY---PSPILSLSVITAG----ASHDDRHLAV 336 Score = 119 bits (297), Expect = 2e-27, Method: Composition-based stats. Identities = 41/208 (19%), Positives = 73/208 (35%), Gaps = 14/208 (6%) Query: 54 HLAKIYAMHWGT-DSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAP---SG 109 H ++ W + L+S S D + +WD + + + +V A+ P + Sbjct: 143 HKQPVWVTKWSPTELTTLMSCSDDKTVRLWDLPSNDPTRLFTGHTDYVRCGAFMPGSANS 202 Query: 110 NYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALW 169 N + G D +++ + G V + H + L + ++ ++ Sbjct: 203 NLLVSGSYDETVRVWDARAPGGAVMTFK----HADPIEDVLPLPSGTTLLAASGNAISVL 258 Query: 170 DIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKL-----WDVREGMCRQTFTG 224 D+ + T H V SLSLA R VSG+ D K+ W+V G + Sbjct: 259 DLVAAKPLRLITNHQKTVTSLSLASQGRRVVSGSLDGHVKVFETTSWNVVAGAKYPSPIL 318 Query: 225 HESDINAICFFPNGNAFATGSDDATCRL 252 S I A + A G + Sbjct: 319 SLSVITAGA-SHDDRHLAVGMQSGVLSI 345 Score = 96.3 bits (238), Expect = 2e-20, Method: Composition-based stats. Identities = 31/165 (18%), Positives = 64/165 (38%), Gaps = 6/165 (3%) Query: 182 GHTGDVMS-LSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNA 240 G T V S L A T + +++ +R+ +T +S+ + P+G Sbjct: 54 GTTALVSSSLVAAAKTNDLFAVTAGPRVEIFSIRKREPLKTIGRFDSEAHCGEIRPDGRV 113 Query: 241 FATGSDDATCRLFDLRADQELMTYSHDN-IICGITSVSFSKSG-RLLLAGYDDFNCNVWD 298 G D ++FD+ + + + +S + L++ DD +WD Sbjct: 114 LVAGEDTGRMQVFDVGQGTRAVILKTWHIHKQPVWVTKWSPTELTTLMSCSDDKTVRLWD 173 Query: 299 ALKADRAGVLAGHDNRVSCLGV---TDDGMAVATGSWDSFLKIWN 340 D + GH + V C + + + +GS+D +++W+ Sbjct: 174 LPSNDPTRLFTGHTDYVRCGAFMPGSANSNLLVSGSYDETVRVWD 218 Score = 52.4 bits (124), Expect = 3e-07, Method: Composition-based stats. Identities = 20/99 (20%), Positives = 41/99 (41%), Gaps = 4/99 (4%) Query: 29 TLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTN 88 L+ N I + + + R + H + ++ + R +VS S DG + ++++ + N Sbjct: 247 LLAASGNAISVLDLVAAKPLRLITNHQKTVTSLSLASQGRRVVSGSLDGHVKVFETTSWN 306 Query: 89 KVHAIPLRSS----WVMTCAYAPSGNYVACGGLDNICSI 123 V S V+T + ++A G + SI Sbjct: 307 VVAGAKYPSPILSLSVITAGASHDDRHLAVGMQSGVLSI 345 >4L9O-A nrPDB Length = 349 Score = 136 bits (342), Expect = 1e-32, Method: Composition-based stats. Identities = 56/269 (20%), Positives = 95/269 (35%), Gaps = 26/269 (9%) Query: 53 GHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNK--VHAIPLRSSWVMTCAYAPS-- 108 H I+ R L + S D + I++ N+ V + V A+A Sbjct: 67 AHDDLIHDAVLDYYGRRLATCSSDKTIKIFEIDGENQRLVETLIGHEGPVWQVAWAHPKF 126 Query: 109 GNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLD---DNQIVTSSGDTT 165 G +A D I+ K G E + H ++ + ++ +S D Sbjct: 127 GVILASCSYDGKVLIW--KEDNGVWNKVAEHSVHQASVNSVSWAPHEYGPVLLCASSDGK 184 Query: 166 CALWDIETGQ--QTTTFTGHTGDVMSLSLAP-----DTRLFVSGACDASAKLWDVREGM- 217 ++ + + G + GH V + S AP +TR FVSG CD K+W + Sbjct: 185 ISIVEFKDGGALEPIVIQGHAIGVNAASWAPISLPDNTRRFVSGGCDNLVKIWRYDDAAK 244 Query: 218 ---CRQTFTGHESDINAICFFPN---GNAFATGSDDATCRLFDL---RADQELMTYSHDN 268 + F GH + + + P+ + AT S D T ++ E + + Sbjct: 245 TFIEEEAFQGHSDWVRDVAWSPSRLSKSYIATASQDRTVLIWTKDGKSNKWEKQPLTKEK 304 Query: 269 IICGITSVSFSKSGRLLLAGYDDFNCNVW 297 S+S SG +L D +W Sbjct: 305 FPDVCWRASWSLSGNVLAISGGDNKVTLW 333 Score = 126 bits (317), Expect = 1e-29, Method: Composition-based stats. Identities = 47/234 (20%), Positives = 83/234 (35%), Gaps = 26/234 (11%) Query: 44 QMRTRRTLRGHLAKIYAMHWGTD--SRLLVSASQDGKLIIW--DSYTTNKVHAIPLRSSW 99 R TL GH ++ + W +L S S DGK++IW D+ NKV + + Sbjct: 102 NQRLVETLIGHEGPVWQVAWAHPKFGVILASCSYDGKVLIWKEDNGVWNKVAEHSVHQAS 161 Query: 100 VMTCAYAPS--GNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLD---- 153 V + ++AP G + C D SI K + + GH ++ + Sbjct: 162 VNSVSWAPHEYGPVLLCASSDGKISIVEFKDGGALEPI--VIQGHAIGVNAASWAPISLP 219 Query: 154 --DNQIVTSSGDTTCALWD----IETGQQTTTFTGHTGDVMSLSLAP---DTRLFVSGAC 204 + V+ D +W +T + F GH+ V ++ +P + + Sbjct: 220 DNTRRFVSGGCDNLVKIWRYDDAAKTFIEEEAFQGHSDWVRDVAWSPSRLSKSYIATASQ 279 Query: 205 DASAKLW--DVREGMCRQ---TFTGHESDINAICFFPNGNAFATGSDDATCRLF 253 D + +W D + + T + +GN A D L+ Sbjct: 280 DRTVLIWTKDGKSNKWEKQPLTKEKFPDVCWRASWSLSGNVLAISGGDNKVTLW 333 Score = 121 bits (304), Expect = 4e-28, Method: Composition-based stats. Identities = 39/221 (17%), Positives = 75/221 (33%), Gaps = 21/221 (9%) Query: 140 AGHTGYL-SCCRFLDDNQIVTSSGDTTCALW--DIETGQQTTTFTGHTGDVMSLSL-APD 195 H + ++ T S D T ++ D E + T GH G V ++ P Sbjct: 66 NAHDDLIHDAVLDYYGRRLATCSSDKTIKIFEIDGENQRLVETLIGHEGPVWQVAWAHPK 125 Query: 196 -TRLFVSGACDASAKLWDVREGMCRQTFTG--HESDINAICFFPN--GNAFATGSDDATC 250 + S + D +W G+ + H++ +N++ + P+ G S D Sbjct: 126 FGVILASCSYDGKVLIWKEDNGVWNKVAEHSVHQASVNSVSWAPHEYGPVLLCASSDGKI 185 Query: 251 RLFDLRADQELMTYSHDNIICGITSVSFSK-----SGRLLLAGYDDFNCNVWDA----LK 301 + + + L G+ + S++ + R ++G D +W Sbjct: 186 SIVEFKDGGALEPIVIQGHAIGVNAASWAPISLPDNTRRFVSGGCDNLVKIWRYDDAAKT 245 Query: 302 ADRAGVLAGHDNRVSCLGVTDDG---MAVATGSWDSFLKIW 339 GH + V + + +AT S D + IW Sbjct: 246 FIEEEAFQGHSDWVRDVAWSPSRLSKSYIATASQDRTVLIW 286 Score = 119 bits (298), Expect = 2e-27, Method: Composition-based stats. Identities = 44/270 (16%), Positives = 88/270 (32%), Gaps = 26/270 (9%) Query: 95 LRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDD 154 + G +A D I+ + N R+ L GH G + + Sbjct: 67 AHDDLIHDAVLDYYGRRLATCSSDKTIKIFEIDG--ENQRLVETLIGHEGPVWQVAWAHP 124 Query: 155 NQ---IVTSSGDTTCALWDIETG--QQTTTFTGHTGDVMSLSLAPD--TRLFVSGACDAS 207 + + S D +W + G + + H V S+S AP + + + D Sbjct: 125 KFGVILASCSYDGKVLIWKEDNGVWNKVAEHSVHQASVNSVSWAPHEYGPVLLCASSDGK 184 Query: 208 AKLWDVREGMCRQ--TFTGHESDINAICFFP-----NGNAFATGSDDATCRLF--DLRAD 258 + + ++G + GH +NA + P N F +G D +++ D A Sbjct: 185 ISIVEFKDGGALEPIVIQGHAIGVNAASWAPISLPDNTRRFVSGGCDNLVKIWRYDDAAK 244 Query: 259 QELMTYSHDNIICGITSVSFSKSG---RLLLAGYDDFNCNVW----DALKADRAGVLAGH 311 + + + V++S S + D +W + K ++ + Sbjct: 245 TFIEEEAFQGHSDWVRDVAWSPSRLSKSYIATASQDRTVLIWTKDGKSNKWEKQPLTKEK 304 Query: 312 DNRV-SCLGVTDDGMAVATGSWDSFLKIWN 340 V + G +A D+ + +W Sbjct: 305 FPDVCWRASWSLSGNVLAISGGDNKVTLWK 334 >3JRP-A nrPDB Length = 379 Score = 133 bits (334), Expect = 1e-31, Method: Composition-based stats. Identities = 50/277 (18%), Positives = 95/277 (34%), Gaps = 34/277 (12%) Query: 53 GHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSY--TTNKVHAIPLRSSWVMTCAYAPS-- 108 H I+ + L + S D + I++ T + + V +A Sbjct: 9 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKF 68 Query: 109 GNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLD---DNQIVTSSGDTT 165 G +A D I+ K G A H+ ++ ++ ++ +S D Sbjct: 69 GTILASCSYDGKVLIW--KEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGK 126 Query: 166 CALWDIETGQQTT--TFTGHTGDVMSLSLAP-------------DTRLFVSGACDASAKL 210 ++ + + T+ H V S S AP ++R FV+G D K+ Sbjct: 127 VSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKI 186 Query: 211 W----DVREGMCRQTFTGHESDINAICFFPN---GNAFATGSDDATCRLF---DLRADQE 260 W D + + T GH + + + P + A+ S D TC ++ + + + Sbjct: 187 WKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWK 246 Query: 261 LMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVW 297 + + S+S SG +L D +W Sbjct: 247 KTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 283 Score = 121 bits (304), Expect = 4e-28, Method: Composition-based stats. Identities = 44/240 (18%), Positives = 82/240 (34%), Gaps = 34/240 (14%) Query: 46 RTRRTLRGHLAKIYAMHWGTD--SRLLVSASQDGKLIIWDSYTTN--KVHAIPLRSSWVM 101 + TL GH ++ + W +L S S DGK++IW ++ + S+ V Sbjct: 46 KLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVN 105 Query: 102 TCAYAPS--GNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLD------ 153 + +AP G + D S+ K + + H ++ + Sbjct: 106 SVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPII--IDAHAIGVNSASWAPATIEED 163 Query: 154 --------DNQIVTSSGDTTCALW----DIETGQQTTTFTGHTGDVMSLSLAPD---TRL 198 + VT D +W D +T +T GH+ V ++ +P Sbjct: 164 GEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSY 223 Query: 199 FVSGACDASAKLW--DVREGMCRQTF---TGHESDINAICFFPNGNAFATGSDDATCRLF 253 S + D + +W D +G ++T + + +GN A D L+ Sbjct: 224 LASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 283 Score = 120 bits (302), Expect = 6e-28, Method: Composition-based stats. Identities = 43/214 (20%), Positives = 74/214 (34%), Gaps = 28/214 (13%) Query: 154 DNQIVTSSGDTTCALWDIE--TGQQTTTFTGHTGDVMSLSL-APD-TRLFVSGACDASAK 209 ++ T S D T ++++E T + T TGH G V + P + S + D Sbjct: 23 GKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVL 82 Query: 210 LWDVREGMCRQTFTG--HESDINAICFFPN--GNAFATGSDDATCRLFDLRADQELMTYS 265 +W G Q H + +N++ + P+ G S D + + + + Sbjct: 83 IWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPII 142 Query: 266 HDNIICGITSVSFSK-------------SGRLLLAGYDDFNCNVW----DALKADRAGVL 308 D G+ S S++ R + G D +W DA L Sbjct: 143 IDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTL 202 Query: 309 AGHDNRVSCLGVTDDG---MAVATGSWDSFLKIW 339 GH + V + + +A+ S D IW Sbjct: 203 EGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIW 236 Score = 111 bits (278), Expect = 4e-25, Method: Composition-based stats. Identities = 42/278 (15%), Positives = 86/278 (30%), Gaps = 34/278 (12%) Query: 95 LRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLD- 153 + + G +A D I+ ++ ++ L GH G + + Sbjct: 9 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEG--ETHKLIDTLTGHEGPVWRVDWAHP 66 Query: 154 --DNQIVTSSGDTTCALWDIETGQ--QTTTFTGHTGDVMSLSLAPD--TRLFVSGACDAS 207 + + S D +W E G+ Q H+ V S+ AP L + + D Sbjct: 67 KFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGK 126 Query: 208 AKLWDVREG--MCRQTFTGHESDINAICFFP-------------NGNAFATGSDDATCRL 252 + + +E H +N+ + P F TG D ++ Sbjct: 127 VSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKI 186 Query: 253 FDLRADQELMTYSH--DNIICGITSVSFSKS---GRLLLAGYDDFNCNVW--DALKADRA 305 + +D + + + V++S + L + D C +W D + Sbjct: 187 WKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWK 246 Query: 306 GVLAGHDNR---VSCLGVTDDGMAVATGSWDSFLKIWN 340 L + + + G +A D+ + +W Sbjct: 247 KTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 284 Score = 92.1 bits (227), Expect = 3e-19, Method: Composition-based stats. Identities = 32/181 (17%), Positives = 59/181 (32%), Gaps = 21/181 (11%) Query: 181 TGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVR--EGMCRQTFTGHESDINAICF-FPN 237 H + L + + + D + K+++V T TGHE + + + P Sbjct: 8 NAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPK 67 Query: 238 -GNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKS--GRLLLAGYDDFNC 294 G A+ S D ++ + H + SV ++ G LLL D Sbjct: 68 FGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKV 127 Query: 295 NVWDALKADRAG--VLAGHDNRVSCLGVTD-------------DGMAVATGSWDSFLKIW 339 +V + + ++ H V+ + TG D+ +KIW Sbjct: 128 SVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIW 187 Query: 340 N 340 Sbjct: 188 K 188 Score = 69.3 bits (168), Expect = 2e-12, Method: Composition-based stats. Identities = 22/127 (17%), Positives = 39/127 (30%), Gaps = 6/127 (4%) Query: 216 GMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITS 275 G H I+ G AT S D T ++F++ + + + + Sbjct: 1 GSMVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWR 60 Query: 276 VSF-SKS-GRLLLAGYDDFNCNVWDALKADR--AGVLAGHDNRVSCLGVTDD--GMAVAT 329 V + G +L + D +W V A H V+ + G + Sbjct: 61 VDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLV 120 Query: 330 GSWDSFL 336 S D + Sbjct: 121 ASSDGKV 127 Score = 55.5 bits (132), Expect = 4e-08, Method: Composition-based stats. Identities = 28/138 (20%), Positives = 49/138 (35%), Gaps = 9/138 (6%) Query: 10 EAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTD--- 66 E + N +++RK + + TL GH + + W Sbjct: 161 EEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLL 220 Query: 67 SRLLVSASQDGKLIIW--DSYTTNKVHAIPLRSSWV---MTCAYAPSGNYVACGGLDNIC 121 L S SQD IIW D+ + + +++ SGN +A G DN Sbjct: 221 RSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKV 280 Query: 122 SIYNLKTREGNVRVSREL 139 +++ + EG + E+ Sbjct: 281 TLWK-ENLEGKWEPAGEV 297 Score = 30.4 bits (67), Expect = 1.1, Method: Composition-based stats. Identities = 8/39 (20%), Positives = 15/39 (38%) Query: 302 ADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 + H+ + + G +AT S D +KI+ Sbjct: 1 GSMVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFE 39 >6ELZ-p nrPDB Length = 460 Score = 132 bits (332), Expect = 2e-31, Method: Composition-based stats. Identities = 55/313 (17%), Positives = 102/313 (32%), Gaps = 76/313 (24%) Query: 95 LRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDD 154 WV + ++ G D I ++L V ++ +GH+G + +++ + Sbjct: 101 SNEDWVSSLDVGDGSKHIISGSYDGIVRTWDLSGN-----VQKQYSGHSGPIRAVKYISN 155 Query: 155 NQIVTSSGDTTCALW-----------------------DIETGQQTTTFTGHTGDVMSLS 191 ++V++ D T LW +IE G+ GH V+S+ Sbjct: 156 TRLVSAGNDRTLRLWKTKNDDLKLTSQQQAQEDDDDEVNIEDGKTLAILEGHKAPVVSID 215 Query: 192 LAPDTRLFVSGACDASAKLWD--------------------------------------V 213 ++ D +S + D S W + Sbjct: 216 VS-DNSRILSASYDNSIGFWSTIYKEMTVVDPLEDINNPNNKISTAARKRRKLTMKDGTI 274 Query: 214 REGMCRQTFTGHESDINAICFFPNGNAFA-TGSDDATCRLFDLRADQELMTYSHDNIICG 272 R H + + + F N + S D T + +DL + + T + + Sbjct: 275 RRRAPLSLLESHTAPVEQVIFDSTDNTVGYSVSQDHTIKTWDLVTARCIDTRTTSYSLLS 334 Query: 273 ITSVSFSKSGRLLLAGYDDFNCNVWDA----LKADRAGVLAGHDNRVSCLGVTDDGMAV- 327 I +S + LL G + + D L GH N VS L + + Sbjct: 335 IAQLS---TLNLLACGSSARHITLHDPRVGASSKVTQQQLIGHKNFVSSLDTCPENEYIL 391 Query: 328 ATGSWDSFLKIWN 340 +GS D +K+W+ Sbjct: 392 CSGSHDGTVKVWD 404 Score = 90.5 bits (223), Expect = 8e-19, Method: Composition-based stats. Identities = 45/259 (17%), Positives = 76/259 (29%), Gaps = 58/259 (22%) Query: 46 RTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDS---------------YTTNKV 90 +T L GH A + ++ D+ ++SAS D + W + NK+ Sbjct: 199 KTLAILEGHKAPVVSIDVS-DNSRILSASYDNSIGFWSTIYKEMTVVDPLEDINNPNNKI 257 Query: 91 HA-----------------------IPLRSSWVMTCAYAPSGNYV-ACGGLDNICSIYNL 126 + ++ V + + N V D+ ++L Sbjct: 258 STAARKRRKLTMKDGTIRRRAPLSLLESHTAPVEQVIFDSTDNTVGYSVSQDHTIKTWDL 317 Query: 127 KTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTT----FTG 182 T R LS + N + S L D G + G Sbjct: 318 VT----ARCIDTRTTSYSLLSIAQLSTLNLLACGSSARHITLHDPRVGASSKVTQQQLIG 373 Query: 183 HTGDVMSLSLAPDTRL-FVSGACDASAKLWDVREGMCRQTF--------TGHESDINAIC 233 H V SL P+ SG+ D + K+WDVR T G + A+ Sbjct: 374 HKNFVSSLDTCPENEYILCSGSHDGTVKVWDVRSTSPMYTITREDKSVQKGVNDKVFAVK 433 Query: 234 FFPNGNAFATGSDDATCRL 252 + + D ++ Sbjct: 434 WA-EKVGIISAGQDKKIQI 451 Score = 55.9 bits (133), Expect = 3e-08, Method: Composition-based stats. Identities = 21/106 (19%), Positives = 41/106 (38%), Gaps = 10/106 (9%) Query: 27 DATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLV-SASQDGKLIIWDSY 85 ++ IT + VG T++ L GH + ++ ++ ++ S S DG + +WD Sbjct: 347 GSSARHITLHDPRVGASSKVTQQQLIGHKNFVSSLDTCPENEYILCSGSHDGTVKVWDVR 406 Query: 86 TTNKVHAIPLRSSWVM--------TCAYAPSGNYVACGGLDNICSI 123 +T+ ++ I V +A + G D I Sbjct: 407 STSPMYTITREDKSVQKGVNDKVFAVKWA-EKVGIISAGQDKKIQI 451 Score = 51.2 bits (121), Expect = 7e-07, Method: Composition-based stats. Identities = 11/77 (14%), Positives = 29/77 (37%), Gaps = 2/77 (2%) Query: 264 YSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDD 323 + + ++S+ + +++G D WD L + +GH + + + Sbjct: 97 LNSFSNEDWVSSLDVGDGSKHIISGSYDGIVRTWD-LSGNVQKQYSGHSGPIRAVKYISN 155 Query: 324 GMAVATGSWDSFLKIWN 340 + + D L++W Sbjct: 156 -TRLVSAGNDRTLRLWK 171 >4BZK-B nrPDB Length = 297 Score = 129 bits (324), Expect = 2e-30, Method: Composition-based stats. Identities = 50/277 (18%), Positives = 95/277 (34%), Gaps = 34/277 (12%) Query: 53 GHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSY--TTNKVHAIPLRSSWVMTCAYAPS-- 108 H I+ + L + S D + I++ T + + V +A Sbjct: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKF 66 Query: 109 GNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLD---DNQIVTSSGDTT 165 G +A D I+ K G A H+ ++ ++ ++ +S D Sbjct: 67 GTILASCSYDGKVLIW--KEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGK 124 Query: 166 CALWDIETGQQTT--TFTGHTGDVMSLSLAP-------------DTRLFVSGACDASAKL 210 ++ + + T+ H V S S AP ++R FV+G D K+ Sbjct: 125 VSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKI 184 Query: 211 W----DVREGMCRQTFTGHESDINAICFFPN---GNAFATGSDDATCRLF---DLRADQE 260 W D + + T GH + + + P + A+ S D TC ++ + + + Sbjct: 185 WKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWK 244 Query: 261 LMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVW 297 + + S+S SG +L D +W Sbjct: 245 KTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 Score = 117 bits (294), Expect = 5e-27, Method: Composition-based stats. Identities = 44/240 (18%), Positives = 82/240 (34%), Gaps = 34/240 (14%) Query: 46 RTRRTLRGHLAKIYAMHWGTD--SRLLVSASQDGKLIIWDSYTTN--KVHAIPLRSSWVM 101 + TL GH ++ + W +L S S DGK++IW ++ + S+ V Sbjct: 44 KLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVN 103 Query: 102 TCAYAPS--GNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLD------ 153 + +AP G + D S+ K + + H ++ + Sbjct: 104 SVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPII--IDAHAIGVNSASWAPATIEED 161 Query: 154 --------DNQIVTSSGDTTCALW----DIETGQQTTTFTGHTGDVMSLSLAPD---TRL 198 + VT D +W D +T +T GH+ V ++ +P Sbjct: 162 GEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSY 221 Query: 199 FVSGACDASAKLW--DVREGMCRQTF---TGHESDINAICFFPNGNAFATGSDDATCRLF 253 S + D + +W D +G ++T + + +GN A D L+ Sbjct: 222 LASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 Score = 117 bits (293), Expect = 7e-27, Method: Composition-based stats. Identities = 43/214 (20%), Positives = 74/214 (34%), Gaps = 28/214 (13%) Query: 154 DNQIVTSSGDTTCALWDIE--TGQQTTTFTGHTGDVMSLSL-APD-TRLFVSGACDASAK 209 ++ T S D T ++++E T + T TGH G V + P + S + D Sbjct: 21 GKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVL 80 Query: 210 LWDVREGMCRQTFTG--HESDINAICFFPN--GNAFATGSDDATCRLFDLRADQELMTYS 265 +W G Q H + +N++ + P+ G S D + + + + Sbjct: 81 IWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPII 140 Query: 266 HDNIICGITSVSFSK-------------SGRLLLAGYDDFNCNVW----DALKADRAGVL 308 D G+ S S++ R + G D +W DA L Sbjct: 141 IDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTL 200 Query: 309 AGHDNRVSCLGVTDDG---MAVATGSWDSFLKIW 339 GH + V + + +A+ S D IW Sbjct: 201 EGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIW 234 Score = 108 bits (269), Expect = 4e-24, Method: Composition-based stats. Identities = 42/278 (15%), Positives = 86/278 (30%), Gaps = 34/278 (12%) Query: 95 LRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLD- 153 + + G +A D I+ ++ ++ L GH G + + Sbjct: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEG--ETHKLIDTLTGHEGPVWRVDWAHP 64 Query: 154 --DNQIVTSSGDTTCALWDIETGQ--QTTTFTGHTGDVMSLSLAPD--TRLFVSGACDAS 207 + + S D +W E G+ Q H+ V S+ AP L + + D Sbjct: 65 KFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGK 124 Query: 208 AKLWDVREG--MCRQTFTGHESDINAICFFP-------------NGNAFATGSDDATCRL 252 + + +E H +N+ + P F TG D ++ Sbjct: 125 VSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKI 184 Query: 253 FDLRADQELMTYSH--DNIICGITSVSFSKS---GRLLLAGYDDFNCNVW--DALKADRA 305 + +D + + + V++S + L + D C +W D + Sbjct: 185 WKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWK 244 Query: 306 GVLAGHDNR---VSCLGVTDDGMAVATGSWDSFLKIWN 340 L + + + G +A D+ + +W Sbjct: 245 KTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 282 Score = 89.4 bits (220), Expect = 2e-18, Method: Composition-based stats. Identities = 32/181 (17%), Positives = 59/181 (32%), Gaps = 21/181 (11%) Query: 181 TGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVR--EGMCRQTFTGHESDINAICF-FPN 237 H + L + + + D + K+++V T TGHE + + + P Sbjct: 6 NAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPK 65 Query: 238 -GNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKS--GRLLLAGYDDFNC 294 G A+ S D ++ + H + SV ++ G LLL D Sbjct: 66 FGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKV 125 Query: 295 NVWDALKADRAG--VLAGHDNRVSCLGVTD-------------DGMAVATGSWDSFLKIW 339 +V + + ++ H V+ + TG D+ +KIW Sbjct: 126 SVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIW 185 Query: 340 N 340 Sbjct: 186 K 186 Score = 82.0 bits (201), Expect = 3e-16, Method: Composition-based stats. Identities = 39/200 (19%), Positives = 66/200 (33%), Gaps = 27/200 (13%) Query: 54 HLAKIYAMHWGTD--SRLLVSASQDGKLII--WDSYTTNKVHAIPLRSSWVMTCAYAP-- 107 H A + ++ W LL+ AS DGK+ + + T I + V + ++AP Sbjct: 98 HSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPAT 157 Query: 108 -----------SGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDD-- 154 GG DN+ I+ + + L GH+ ++ + Sbjct: 158 IEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVL 217 Query: 155 --NQIVTSSGDTTCALW--DIETGQQTTTFTGHTGD---VMSLSLAPDTRLFVSGACDAS 207 + + + S D TC +W D E G T + S + + D Sbjct: 218 LRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNK 277 Query: 208 AKLWDVR-EGMCRQTFTGHE 226 LW EG H+ Sbjct: 278 VTLWKENLEGKWEPAGEVHQ 297 Score = 53.9 bits (128), Expect = 1e-07, Method: Composition-based stats. Identities = 25/124 (20%), Positives = 43/124 (34%), Gaps = 8/124 (6%) Query: 10 EAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTD--- 66 E + N +++RK + + TL GH + + W Sbjct: 159 EEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLL 218 Query: 67 SRLLVSASQDGKLIIW--DSYTTNKVHAIPLRSSWV---MTCAYAPSGNYVACGGLDNIC 121 L S SQD IIW D+ + + +++ SGN +A G DN Sbjct: 219 RSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKV 278 Query: 122 SIYN 125 +++ Sbjct: 279 TLWK 282 >2AQ5-A nrPDB Length = 402 Score = 129 bits (323), Expect = 3e-30, Method: Composition-based stats. Identities = 45/218 (20%), Positives = 75/218 (34%), Gaps = 18/218 (8%) Query: 141 GHTGYLSCCRF--LDDNQIVTSSGDTTCALWDIETG-------QQTTTFTGHTGDVMSLS 191 GHT + + +DN I + S D T +W+I G + T GHT V ++ Sbjct: 79 GHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKRVGIVA 138 Query: 192 LAP-DTRLFVSGACDASAKLWDVREGMCRQTF--TGHESDINAICFFPNGNAFATGSDDA 248 P + +S CD +WDV G T H I ++ + +G T D Sbjct: 139 WHPTAQNVLLSAGCDNVILVWDVGTGAAVLTLGPDVHPDTIYSVDWSRDGALICTSCRDK 198 Query: 249 TCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGY---DDFNCNVWDALKADRA 305 R+ + R + + F G++L G+ + +WD + Sbjct: 199 RVRVIEPRKGTVVAEKDRPHEGTRPVHAVFVSEGKILTTGFSRMSERQVALWDTKHLEEP 258 Query: 306 GVLA--GHDNRVSCLGVTDDGMAVATGSW-DSFLKIWN 340 L + V D V DS ++ + Sbjct: 259 LSLQELDTSSGVLLPFFDPDTNIVYLCGKGDSSIRYFE 296 Score = 109 bits (272), Expect = 2e-24, Method: Composition-based stats. Identities = 39/231 (16%), Positives = 87/231 (37%), Gaps = 22/231 (9%) Query: 53 GHLAKIYAMHWGT-DSRLLVSASQDGKLIIWDSYTT-------NKVHAIPLRSSWVMTCA 104 GH A + + W + ++ S S+D +++W+ V + + V A Sbjct: 79 GHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKRVGIVA 138 Query: 105 YAPSG-NYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIV-TSSG 162 + P+ N + G DN+ ++++ T + + ++ H + + D ++ TS Sbjct: 139 WHPTAQNVLLSAGCDNVILVWDVGTGAAVLTLGPDV--HPDTIYSVDWSRDGALICTSCR 196 Query: 163 DTTCALWDIETGQQTTT-FTGHTG--DVMSLSLAPDTRLFVSG---ACDASAKLWDVREG 216 D + + G H G V ++ + ++ +G + LWD + Sbjct: 197 DKRVRVIEPRKGTVVAEKDRPHEGTRPVHAV-FVSEGKILTTGFSRMSERQVALWDTKHL 255 Query: 217 MCRQTFT--GHESDINAICFFPNGNAF-ATGSDDATCRLFDLRADQELMTY 264 + S + F P+ N G D++ R F++ ++ + Y Sbjct: 256 EEPLSLQELDTSSGVLLPFFDPDTNIVYLCGKGDSSIRYFEITSEAPFLHY 306 Score = 86.3 bits (212), Expect = 2e-17, Method: Composition-based stats. Identities = 31/176 (17%), Positives = 67/176 (38%), Gaps = 12/176 (6%) Query: 50 TLRGHLAKIYAMHWGTD-SRLLVSASQDGKLIIWDSYTTNKVHAI--PLRSSWVMTCAYA 106 TL GH ++ + W +L+SA D +++WD T V + + + + ++ Sbjct: 126 TLEGHTKRVGIVAWHPTAQNVLLSAGCDNVILVWDVGTGAAVLTLGPDVHPDTIYSVDWS 185 Query: 107 PSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSG---- 162 G + D + + R G T + F+ + +I+T+ Sbjct: 186 RDGALICTSCRDKRVRVIEPRKGTVVAEKDRPHEG-TRPVHAV-FVSEGKILTTGFSRMS 243 Query: 163 DTTCALWDIETGQQTTTFT--GHTGDVMSLSLAPDTRLFVSGAC-DASAKLWDVRE 215 + ALWD + ++ + + V+ PDT + D+S + +++ Sbjct: 244 ERQVALWDTKHLEEPLSLQELDTSSGVLLPFFDPDTNIVYLCGKGDSSIRYFEITS 299 >4A11-B nrPDB Length = 408 Score = 127 bits (320), Expect = 5e-30, Method: Composition-based stats. Identities = 61/321 (19%), Positives = 100/321 (31%), Gaps = 78/321 (24%) Query: 96 RSSWVMTCAYAP-SGNYVACGGLDNICSIYNL--KTREGNVRVSRELA-------GHTGY 145 + T P G Y+ GG D + +Y+L +R+ + H Sbjct: 42 HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYS 101 Query: 146 LSCCRF--LDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTR---LFV 200 + ++ D +SS D T +WD T Q F V S ++P + L Sbjct: 102 VETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEE-TVYSHHMSPVSTKHCLVA 160 Query: 201 SGACDASAKLWDVREGMCRQTFTGHESDINAICFFPN-GNAFATGSDDATCRLFDLR-AD 258 G +L D++ G C GH +I A+ + P AT S D+ +L+D+R A Sbjct: 161 VGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRAS 220 Query: 259 QELMTYSHDN-------------IICGITSVSFSKSGRLLLAGYDDFNCNVWD------- 298 L+T N + + F+ G LL D +W+ Sbjct: 221 GCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENT 280 Query: 299 ----------------------------------------ALKADRAGVLAGHDNRVSCL 318 ++ +L GH V C Sbjct: 281 LVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCC 340 Query: 319 GVTDDGMAVATGSWDSFLKIW 339 + + +GS D + W Sbjct: 341 VFQSNFQELYSGSRDCNILAW 361 Score = 99.4 bits (246), Expect = 2e-21, Method: Composition-based stats. Identities = 47/235 (20%), Positives = 83/235 (35%), Gaps = 39/235 (16%) Query: 142 HTGYLSCCRFLD--DNQIVTSSGDTTCALWDIETGQQTTTFT-------------GHTGD 186 H G ++ +++ D L+D+E + + +T H Sbjct: 42 HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYS 101 Query: 187 VMSLSLAP-DTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGN---AFA 242 V ++ P DT +F S + D + K+WD F E + + P A Sbjct: 102 VETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFN-FEETVYSHHMSPVSTKHCLVA 160 Query: 243 TGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLA-GYDDFNCNVWDALK 301 G+ +L DL++ I +VS+S +LA D +WD + Sbjct: 161 VGTRGPKVQLCDLKSGSCSHIL--QGHRQEILAVSWSPRYDYILATASADSRVKLWDVRR 218 Query: 302 AD-RAGVL---------------AGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 A L H+ +V+ L T DG+ + T D+ +++WN Sbjct: 219 ASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWN 273 Score = 99.0 bits (245), Expect = 3e-21, Method: Composition-based stats. Identities = 49/287 (17%), Positives = 91/287 (31%), Gaps = 48/287 (16%) Query: 54 HLAKIYAMHWGT-DSRLLVSASQDGKLIIWDSYT------TNKVHAIPLRSSWVMTCAYA 106 H + + W D+ + S+S D L +WD+ T N + ++ + Sbjct: 98 HRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKH- 156 Query: 107 PSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLD--DNQIVTSSGDT 164 VA G + +LK+ S L GH + + D + T+S D+ Sbjct: 157 ---CLVAVGTRGPKVQLCDLKSG----SCSHILQGHRQEILAVSWSPRYDYILATASADS 209 Query: 165 TCALWDIE-TGQQTTTF---------------TGHTGDVMSLSLAPDTRLFVSGACDASA 208 LWD+ T T H G V L D ++ D Sbjct: 210 RVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRM 269 Query: 209 KLWDVREGM---------CRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQ 259 +LW+ G C + G + ++ C + F +T ++ + + + Sbjct: 270 RLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGC----SSEFVFVPYGSTIAVYTVYSGE 325 Query: 260 ELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAG 306 ++ + F + + L +G D N W + Sbjct: 326 QITML--KGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLYEPVP 370 Score = 85.5 bits (210), Expect = 3e-17, Method: Composition-based stats. Identities = 35/185 (18%), Positives = 68/185 (36%), Gaps = 23/185 (12%) Query: 48 RRTLRGHLAKIYAMHWGTDSRL-LVSASQDGKLIIWDS------------YTTNKVHAIP 94 L+GH +I A+ W L +AS D ++ +WD + K A+ Sbjct: 179 SHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVE 238 Query: 95 ----LRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCR 150 + V + G ++ G DN ++N E + ++ ++ + Sbjct: 239 SANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSK--KGLK 296 Query: 151 FLDD----NQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDA 206 F ++ V +T A++ + +G+Q T GH V + + SG+ D Sbjct: 297 FTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDC 356 Query: 207 SAKLW 211 + W Sbjct: 357 NILAW 361 >3BG0-A nrPDB Length = 316 Score = 126 bits (316), Expect = 1e-29, Method: Composition-based stats. Identities = 55/265 (20%), Positives = 87/265 (32%), Gaps = 36/265 (13%) Query: 51 LRGHLAKIYAMHWGTD--SRLLVSASQDGKLIIW--DSYTTNKVHAIPLRSSWVMTCAYA 106 LRGH ++ + W +L S S D K+IIW ++ T K H S V + +A Sbjct: 53 LRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWA 112 Query: 107 PS--GNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDD---------- 154 P G +ACG D S+ T EG V + HT + + Sbjct: 113 PHDYGLILACGSSDGAISLLTY-TGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHP 171 Query: 155 --------NQIVTSSGDTTCALWDIETG---QQTTTFTGHTGDVMSLSLAPD----TRLF 199 + + D LW E ++ H+ V ++ AP T Sbjct: 172 SGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTI 231 Query: 200 VSGACDASAKLW---DVREGMC-RQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDL 255 S + D +W D + + + + N A D L+ Sbjct: 232 ASCSQDGRVFIWTCDDASSNTWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKE 291 Query: 256 RADQELMTYSHDNIICGITSVSFSK 280 D + + S N G S S ++ Sbjct: 292 SVDGQWVCISDVNKGQGSVSASVTE 316 Score = 110 bits (274), Expect = 1e-24, Method: Composition-based stats. Identities = 53/282 (18%), Positives = 89/282 (31%), Gaps = 42/282 (14%) Query: 54 HLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNK--VHAIPLRSSWVMTCAYAP--SG 109 H I+ L + S D + I+D + + + V A+A G Sbjct: 12 HEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYG 71 Query: 110 NYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQ---IVTSSGDTTC 166 N +A D I+ + G S E AGH ++ + + + S D Sbjct: 72 NILASCSYDRKVIIW--REENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAI 129 Query: 167 ALWDIETG----QQTTTFTGHTGDVMSLSL-----------APDTR------LFVSGACD 205 +L TG + HT ++S P + F SG CD Sbjct: 130 SL-LTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCD 188 Query: 206 ASAKLWDVREG---MCRQTFTGHESDINAICFFPN----GNAFATGSDDATCRLF---DL 255 KLW E Q H + + + P+ + A+ S D ++ D Sbjct: 189 NLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDA 248 Query: 256 RADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVW 297 ++ H + VS+S + +L D +W Sbjct: 249 SSNTWSPKLLHK-FNDVVWHVSWSITANILAVSGGDNKVTLW 289 Score = 105 bits (261), Expect = 4e-23, Method: Composition-based stats. Identities = 43/219 (19%), Positives = 74/219 (33%), Gaps = 33/219 (15%) Query: 154 DNQIVTSSGDTTCALWDIETGQQ--TTTFTGHTGDVMSLSL-AP-DTRLFVSGACDASAK 209 ++ T S D + ++D+ G Q GH G V ++ P + S + D Sbjct: 25 GTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVI 84 Query: 210 LWDVREGMC--RQTFTGHESDINAICFFPNGN--AFATGSDDATCRLFD-LRADQELMTY 264 +W G GH+S +N++C+ P+ A GS D L Q + Sbjct: 85 IWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKK 144 Query: 265 SHDNIICGITSVSF-----------SKSG------RLLLAGYDDFNCNVWDALK---ADR 304 ++ G +VS+ SG + +G D +W + Sbjct: 145 INNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKE 204 Query: 305 AGVLAGHDNRVSCLGVTDD----GMAVATGSWDSFLKIW 339 L H + V + +A+ S D + IW Sbjct: 205 EQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIW 243 Score = 102 bits (254), Expect = 3e-22, Method: Composition-based stats. Identities = 47/283 (16%), Positives = 92/283 (32%), Gaps = 38/283 (13%) Query: 94 PLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLD 153 + G +A D I+++ R G + +L GH G + + Sbjct: 10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDV--RNGGQILIADLRGHEGPVWQVAWAH 67 Query: 154 ---DNQIVTSSGDTTCALWDIETG--QQTTTFTGHTGDVMSLSLAPD--TRLFVSGACDA 206 N + + S D +W E G +++ GH V S+ AP + G+ D Sbjct: 68 PMYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDG 127 Query: 207 SAKLWDVR-EGMC--RQTFTGHESDINAICF-----------FPNG------NAFATGSD 246 + L EG ++ H NA+ + P+G FA+G Sbjct: 128 AISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGC 187 Query: 247 DATCRLF-DLRADQELMTYSHDNIICGITSVSFSKS----GRLLLAGYDDFNCNVWDA-- 299 D +L+ + Q + + V+++ S + + D +W Sbjct: 188 DNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDD 247 Query: 300 --LKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 +L ++ V + + +A D+ + +W Sbjct: 248 ASSNTWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWK 290 Score = 88.6 bits (218), Expect = 4e-18, Method: Composition-based stats. Identities = 33/189 (17%), Positives = 63/189 (33%), Gaps = 26/189 (13%) Query: 178 TTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREG--MCRQTFTGHESDINAICF- 234 T T H + + + + D S K++DVR G + GHE + + + Sbjct: 7 TVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWA 66 Query: 235 FPN-GNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKS--GRLLLAGYDD 291 P GN A+ S D ++ ++ H + SV ++ G +L G D Sbjct: 67 HPMYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSD 126 Query: 292 FNCNVWDAL---KADRAGVLAGHDNRVSCLGV-----------TDDGM------AVATGS 331 ++ + + + H + + G A+G Sbjct: 127 GAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGG 186 Query: 332 WDSFLKIWN 340 D+ +K+W Sbjct: 187 CDNLIKLWK 195 Score = 48.5 bits (114), Expect = 4e-06, Method: Composition-based stats. Identities = 21/116 (18%), Positives = 49/116 (42%), Gaps = 15/116 (12%) Query: 44 QMRTRRTLRGHLAKIYAMHWGT----DSRLLVSASQDGKLIIW-------DSYTTNKVHA 92 Q + + L H + + W + + S SQDG++ IW ++++ +H Sbjct: 201 QWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASSNTWSPKLLHK 260 Query: 93 IPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSC 148 + V +++ + N +A G DN +++ ++ +G ++ G +S Sbjct: 261 F---NDVVWHVSWSITANILAVSGGDNKVTLWK-ESVDGQWVCISDVNKGQGSVSA 312 >4E5Z-B nrPDB Length = 436 Score = 123 bits (308), Expect = 1e-28, Method: Composition-based stats. Identities = 49/330 (14%), Positives = 112/330 (33%), Gaps = 21/330 (6%) Query: 17 QIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRG---HLAKIYAMHWGTD-SRLLVS 72 + K + S + + + + R L+ + ++ W + Sbjct: 79 RTLHQHKLGRASWPS-VQQGLQQSFLHTLDSYRILQKAAPFDRRATSLAWHPTHPSTVAV 137 Query: 73 ASQDGKLIIWDSYTTNKVHAIPL--RSSWVMTCAYAP-SGNYVACGGLDNICSIYNLKTR 129 S+ G +++W+ +K I + + P + N ++ + + K Sbjct: 138 GSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFK-G 196 Query: 130 EGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMS 189 + + + S +VT L +++ G++ H V Sbjct: 197 NILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMD-GKELWNLRMHKKKVTH 255 Query: 190 LSLAPDTRLF-VSGACDASAKLWDVREGMCRQTFT---GHESDINAICFFPNGNAFATGS 245 ++L P F + + D + K+WD+R+ + +F H +NA CF P+G T Sbjct: 256 VALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTD 315 Query: 246 DDATCRL-----FDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAG-YDDFNCNVWDA 299 + R+ +D + H + I + ++ L++ G Y D N Sbjct: 316 QKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKA-AWHPRYNLIVVGRYPDPNFKSCTP 374 Query: 300 LKADRAGVLAGHDNRVSCLGVTDDGMAVAT 329 + V G+ ++ C + +++ Sbjct: 375 YELRTIDVFDGNSGKMMCQLYDPESSGISS 404 Score = 77.0 bits (188), Expect = 1e-14, Method: Composition-based stats. Identities = 37/158 (23%), Positives = 60/158 (37%), Gaps = 6/158 (3%) Query: 188 MSLSLAP-DTRLFVSGACDASAKLWDVREGMCRQTFTG--HESDINAICFFP-NGNAFAT 243 SL+ P G+ LW+ G I + F P N N F Sbjct: 123 TSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYA 182 Query: 244 GSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKAD 303 S + T RL D + + + S D I S+ S S R+++ G + N + + + Sbjct: 183 SSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLN-MDGK 241 Query: 304 RAGVLAGHDNRVSCLGVTDDGMA-VATGSWDSFLKIWN 340 L H +V+ + + +AT S D +KIW+ Sbjct: 242 ELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWD 279 Score = 67.8 bits (164), Expect = 7e-12, Method: Composition-based stats. Identities = 38/224 (16%), Positives = 73/224 (32%), Gaps = 39/224 (17%) Query: 143 TGYLSCCRFLDD--NQIVTSSGDTTCALWDIETGQQTTTFTGHT--GDVMSLSLAP-DTR 197 + + + + S LW+ + T G G + L P +T Sbjct: 119 DRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTN 178 Query: 198 LFVSGACDASAKLWDVREGMCRQTFTGHESDIN----AICFFPNGNAFATGSDDATC--- 250 F + + + + +L D + G + F IN ++ + TG + Sbjct: 179 QFYASSMEGTTRLQDFK-GNILRVF-ASSDTINIWFCSLDVSASSRMVVTGDNVGNVILL 236 Query: 251 -----RLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDAL----K 301 L++LR ++ +T+ N C + L D +WD K Sbjct: 237 NMDGKELWNLRMHKKKVTHVALNPCC-----DW-----FLATASVDQTVKIWDLRQVRGK 286 Query: 302 ADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKI-----WN 340 A L H + V+ + DG + T S +++ W+ Sbjct: 287 ASFLYSLP-HRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWD 329 Score = 45.8 bits (107), Expect = 3e-05, Method: Composition-based stats. Identities = 14/134 (10%), Positives = 40/134 (29%), Gaps = 20/134 (14%) Query: 54 HLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSS------WVMTCAYAP 107 H + A + D L++ Q ++ ++ + + + + A+ P Sbjct: 295 HRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHP 354 Query: 108 SGNYVACGGLD------------NICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDN 155 N + G +++ + + ++ + +G S F Sbjct: 355 RYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPES--SGISSLNEFNPMG 412 Query: 156 QIVTSSGDTTCALW 169 + S+ +W Sbjct: 413 DTLASAMGYHILIW 426 >5WLC-LJ nrPDB Length = 513 Score = 122 bits (307), Expect = 2e-28, Method: Composition-based stats. Identities = 55/318 (17%), Positives = 112/318 (35%), Gaps = 22/318 (6%) Query: 18 IRDARKACADATLSQITNNIDPVGRI--QMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQ 75 + AR + + P R Q + + ++ H + + + + + + Sbjct: 1 MSTARPRIITSKAPLLPQQTTPEQRYWRQYTSAQLVKEHNS-VTHISFNPQHPHDFAVTS 59 Query: 76 DGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRV 135 ++ I+ S T + V + ++ G + G + S+Y+ + Sbjct: 60 STRVQIFSSRTRQVIKTFSRFKDVVYSASFRSDGKLLCAGDATGLVSVYDSYNP---RTI 116 Query: 136 SRELAGHTGYLSCCRFL--DDNQIVTSSGDTTCALWDIETG-QQTTTFTGHTGDVMSLSL 192 + T +F D+ + T+S D LWDI + TG T V +LS Sbjct: 117 LLSINASTHPTHVTKFHTQDNKILATASDDRVTRLWDISNAYEPQLELTGATDYVRTLSF 176 Query: 193 APDTRLF-VSGACDASAKLWDVREGMCRQTFT-GHESDI-NAICFFPNGNAFATGSDDAT 249 P +G+ D +L+D R ++ H+ + N I P + + Sbjct: 177 IPAAPHLVATGSYDGLIRLYDTRSSGSTPIYSLNHDQPVENVIAVSPT--QIVSCGGNN- 233 Query: 250 CRLFDLRADQELMTYSHDNIICGITSVSF-----SKSGRLLLAGYDDFNCNVWDALKADR 304 +++DL ++++L Y N +T + + S L+A D + V+D L + Sbjct: 234 FKVWDLTSNKKL--YERGNFNKAVTCLDYVENFDSPMQSALIASSLDGHVKVFDPLDNFQ 291 Query: 305 AGVLAGHDNRVSCLGVTD 322 V V+ Sbjct: 292 VKFGWKFSGPVLSCAVSP 309 Score = 115 bits (287), Expect = 4e-26, Method: Composition-based stats. Identities = 50/274 (18%), Positives = 102/274 (37%), Gaps = 26/274 (9%) Query: 80 IIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSREL 139 W YT+ + +S V ++ P + I++ +TR+ V + Sbjct: 25 RYWRQYTS--AQLVKEHNS-VTHISFNPQHPHDFAVTSSTRVQIFSSRTRQ----VIKTF 77 Query: 140 AGHTGYLSCCRFLDDNQIVTSSGDTT--CALWDIETGQQTT-TFTGHTGDVMSLSLA-PD 195 + + F D +++ +GD T +++D + + T D Sbjct: 78 SRFKDVVYSASFRSDGKLL-CAGDATGLVSVYDSYNPRTILLSINASTHPTHVTKFHTQD 136 Query: 196 TRLFVSGACDASAKLWDVREG-MCRQTFTGHESDINAICFFPN-GNAFATGSDDATCRLF 253 ++ + + D +LWD+ + TG + + F P + ATGS D RL+ Sbjct: 137 NKILATASDDRVTRLWDISNAYEPQLELTGATDYVRTLSFIPAAPHLVATGSYDGLIRLY 196 Query: 254 DLRA--DQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGH 311 D R+ + + +HD + + +V S +++ N VWD + Sbjct: 197 DTRSSGSTPIYSLNHDQPVENVIAV----SPTQIVSCGG-NNFKVWDLTSNKKLYERGNF 251 Query: 312 DNRVSCLGV-----TDDGMAVATGSWDSFLKIWN 340 + V+CL + A+ S D +K+++ Sbjct: 252 NKAVTCLDYVENFDSPMQSALIASSLDGHVKVFD 285 Score = 99.0 bits (245), Expect = 2e-21, Method: Composition-based stats. Identities = 45/278 (16%), Positives = 97/278 (34%), Gaps = 23/278 (8%) Query: 34 TNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSY-TTNKVHA 92 + + + +T +Y+ + +D +LL + G + ++DSY + + Sbjct: 60 STRVQIFSSRTRQVIKTFSRFKDVVYSASFRSDGKLLCAGDATGLVSVYDSYNPRTILLS 119 Query: 93 IPLRSSWVMTCAYAP-SGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRF 151 I + + +A D + ++++ EL G T Y+ F Sbjct: 120 INASTHPTHVTKFHTQDNKILATASDDRVTRLWDISN---AYEPQLELTGATDYVRTLSF 176 Query: 152 LDD--NQIVTSSGDTTCALWDIETGQQTTTFT-GHTGDVMSL-SLAPDTRLFVSGACDAS 207 + + + T S D L+D + T ++ H V ++ +++P VS + Sbjct: 177 IPAAPHLVATGSYDGLIRLYDTRSSGSTPIYSLNHDQPVENVIAVSP--TQIVSCGGNNF 234 Query: 208 AKLWDVREGMCRQTFTGHESDINAICF-----FPNGNAFATGSDDATCRLFDLRADQELM 262 K+WD+ + + + P +A S D ++FD + ++ Sbjct: 235 -KVWDLTSNKKLYERGNFNKAVTCLDYVENFDSPMQSALIASSLDGHVKVFDPLDNFQVK 293 Query: 263 TYSHDNIICGITSVSFSKS----GRLLLAGYDDFNCNV 296 + S + S S R L+AG + Sbjct: 294 F--GWKFSGPVLSCAVSPSTAQGNRHLVAGLSSGLLAI 329 Score = 88.6 bits (218), Expect = 4e-18, Method: Composition-based stats. Identities = 35/280 (12%), Positives = 90/280 (32%), Gaps = 16/280 (5%) Query: 54 HLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTT-NKVHAIPLRSSWVMTCAYAPSGNYV 112 H + H D+++L +AS D +WD + + +V T ++ P+ ++ Sbjct: 125 HPTHVTKFH-TQDNKILATASDDRVTRLWDISNAYEPQLELTGATDYVRTLSFIPAAPHL 183 Query: 113 -ACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDI 171 A G D + +Y+ ++ S H + + QIV+ G +WD+ Sbjct: 184 VATGSYDGLIRLYDTRSSGSTPIYSLN---HDQPVENVIAVSPTQIVSCGG-NNFKVWDL 239 Query: 172 ETGQQTTTFTGHTGDVMSLSL-----APDTRLFVSGACDASAKLWDVREGMCRQTFTGHE 226 + ++ V L +P ++ + D K++D + + Sbjct: 240 TSNKKLYERGNFNKAVTCLDYVENFDSPMQSALIASSLDGHVKVFDPLDNFQVKFGWKFS 299 Query: 227 SDINAICFFPN----GNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSG 282 + + P+ G + + ++ + + S + Sbjct: 300 GPVLSCAVSPSTAQGNRHLVAGLSSGLLAIRTKKKEKRSSDKENAPASFNKNAKSNNFQR 359 Query: 283 RLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTD 322 + + Y ++ K + + ++ ++ Sbjct: 360 MMRGSEYQGDQEHIIHNDKVRSQRRMRAFERNINQFKWSE 399 >1PI6-A nrPDB Length = 615 Score = 122 bits (307), Expect = 2e-28, Method: Composition-based stats. Identities = 49/312 (15%), Positives = 115/312 (36%), Gaps = 29/312 (9%) Query: 51 LRGH-LAKIYAMHWGT--DSRLLVSASQDGKLIIW--------DSYTTNKVHAIPLRSSW 99 GH + + + + S+ L S + GK+I+W +S N + + Sbjct: 59 FTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGP 118 Query: 100 VMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDN--QI 157 + ++ G + G + + + E++GH+ ++ C + Sbjct: 119 ISDISWDFEGRRLCVVGEGR--DNFGVFISWDSGNSLGEVSGHSQRINACHLKQSRPMRS 176 Query: 158 VTSSGDTTCALWDIETGQQTTTFTGHT---GDVMSLSLAPD-TRLFVSGACDASAKLWDV 213 +T D + + + + + H V + +PD ++ D +D Sbjct: 177 MTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDG 236 Query: 214 REGMCRQTFTGHESDI----NAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNI 269 + G + + + A+ + + FAT DAT R++D+ + + ++ D Sbjct: 237 KSGEFLKYIEDDQEPVQGGIFALSWL-DSQKFATVGADATIRVWDVTTSKCVQKWTLDKQ 295 Query: 270 ICGITSVSFSKSGR-LLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVA 328 G V +G +++ D N ++ + ++GH+ ++ L V + Sbjct: 296 QLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNP----LI 351 Query: 329 TGSWDSFLKIWN 340 +GS+D + W+ Sbjct: 352 SGSYDGRIMEWS 363 Score = 95.9 bits (237), Expect = 2e-20, Method: Composition-based stats. Identities = 46/253 (18%), Positives = 89/253 (35%), Gaps = 20/253 (7%) Query: 52 RGHLAKIYAMHW-GTDSRLLVSASQDGKLIIWDSYTTNKV---HAIPLRSSWVMTCAYAP 107 GH +I A H + ++ DG ++ + + S+V ++P Sbjct: 157 SGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSP 216 Query: 108 S-GNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTC 166 G +V G D S ++ K+ E + + G + +LD + T D T Sbjct: 217 DSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATI 276 Query: 167 ALWDIETGQQTTTFTGHTGDVMSLS---LAPDTRLFVSGACDASAKLWDVREGMCRQTFT 223 +WD+ T + +T + + +A +S + D + +++ +T + Sbjct: 277 RVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTIS 336 Query: 224 GHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGR 283 GH I A+ P +GS D + + H + I S+ SK+ Sbjct: 337 GHNKGITALTVNP----LISGSYDGRIMEWSSSS-------MHQDHSNLIVSLDNSKAQE 385 Query: 284 LLLAGYDDFNCNV 296 + D V Sbjct: 386 Y-SSISWDDTLKV 397 Score = 76.7 bits (187), Expect = 2e-14, Method: Composition-based stats. Identities = 49/321 (15%), Positives = 100/321 (31%), Gaps = 59/321 (18%) Query: 64 GTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSI 123 T + ++S S DG L ++ + I + + P + G D Sbjct: 306 ATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNP----LISGSYDGRIME 361 Query: 124 YNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCA---LWDIETGQQTTTF 180 ++ + H+ + + + S D T + E G Q Sbjct: 362 WSSSS---------MHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVA 412 Query: 181 TGHTGDVMSLSLAPDTRLF---VSGACDASAKLWD---------------VREGMCRQTF 222 + + ++ D L +G S +L + EG Q F Sbjct: 413 SANNDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVF 472 Query: 223 TGHESDINA------------ICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNII 270 + +++ I P+ A G L+DL++ +E+ T Sbjct: 473 KLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQS-REVKTSRWAFRT 531 Query: 271 CGITSVSFSKSGR----------LLLAGYDDFNCNVWDALKADR-AGVLAGHDNRVSCLG 319 I ++S+ + + L+ G D N ++ + + L H + V+ L Sbjct: 532 SKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLL 591 Query: 320 VTDDGMAVATGSWDSFLKIWN 340 + + + D+ +K WN Sbjct: 592 W-ETPSTLVSSGADACIKRWN 611 Score = 55.9 bits (133), Expect = 3e-08, Method: Composition-based stats. Identities = 34/209 (16%), Positives = 78/209 (37%), Gaps = 21/209 (10%) Query: 61 MHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDN- 119 + + + D L+I S+T + + ++ L S A + S NYVA G + Sbjct: 411 VASANNDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPGS---AVSLSQNYVAVGLEEGN 467 Query: 120 ICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGD-TTCALWDIETGQQTT 178 ++ L E + + L Y+S + + L+D+++ + T Sbjct: 468 TIQVFKLSDLEVSFDLKTPLRAKPSYIS---ISPSETYIAAGDVMGKILLYDLQSREVKT 524 Query: 179 TF-TGHTGDVMSLSLAP----------DTRLFVSGACDASAKLWDV-REGMCRQTFTGHE 226 + T + ++S P + L +G+ D + ++ V R + H+ Sbjct: 525 SRWAFRTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNAHK 584 Query: 227 SDINAICFFPNGNAFATGSDDATCRLFDL 255 +N + + + + DA + +++ Sbjct: 585 DGVNNLLWE-TPSTLVSSGADACIKRWNV 612 Score = 50.8 bits (120), Expect = 8e-07, Method: Composition-based stats. Identities = 26/184 (14%), Positives = 65/184 (35%), Gaps = 26/184 (14%) Query: 11 AEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYA---------- 60 + I + + + + ++ N VG + T + + ++ Sbjct: 432 LQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAKP 491 Query: 61 --MHWGTDSRLLVSASQDGKLIIWDSYTTN-KVHAIPLRSSWVMTCAYAP---------- 107 + + + GK++++D + K R+S + ++ P Sbjct: 492 SYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFRTSKINAISWKPAEKGANEEEI 551 Query: 108 SGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCA 167 + VA G LD IY++K +++ + L H ++ + + +V+S D Sbjct: 552 EEDLVATGSLDTNIFIYSVKRP---MKIIKALNAHKDGVNNLLWETPSTLVSSGADACIK 608 Query: 168 LWDI 171 W++ Sbjct: 609 RWNV 612 Score = 48.9 bits (115), Expect = 3e-06, Method: Composition-based stats. Identities = 33/178 (18%), Positives = 64/178 (35%), Gaps = 27/178 (15%) Query: 58 IYAMHWGTDSRLLVSASQD---------GKLIIWDSYTTNKVHAIPLRSSWVMT-CAYAP 107 I ++ + VS SQ+ + ++ + + + +P Sbjct: 440 IKSVRLNSPGS-AVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYISISP 498 Query: 108 SGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLD-----------DNQ 156 S Y+A G + +Y+L++RE V+ SR A T ++ + ++ Sbjct: 499 SETYIAAGDVMGKILLYDLQSRE--VKTSRW-AFRTSKINAISWKPAEKGANEEEIEEDL 555 Query: 157 IVTSSGDTTCALWDIETG-QQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDV 213 + T S DT ++ ++ + H V +L VS DA K W+V Sbjct: 556 VATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLWET-PSTLVSSGADACIKRWNV 612 >5M89-A nrPDB Length = 329 Score = 122 bits (306), Expect = 2e-28, Method: Composition-based stats. Identities = 49/227 (21%), Positives = 93/227 (40%), Gaps = 16/227 (7%) Query: 108 SGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCA 167 A GGLD IY++ +V R L ++ + ++V + Sbjct: 62 ENECAAVGGLDGKLDIYSVVAN----KVERTLDI-GEPVTATEWT-GTKVVIGTAKGWVK 115 Query: 168 LWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGH-E 226 ++D G+++ TF H G V L++ P R+ S D S +D+ G + G+ + Sbjct: 116 VYD--AGRESATFQTHAGPVTGLAVHPGGRILASVGVDKSFVFYDLETGE--RVARGYAD 171 Query: 227 SDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLL 286 + + F P+GN FA G+ +F ++ ++ + I +++FS++G Sbjct: 172 AALTTCAFHPDGNLFAAGTQTGHILVFHTTTLEQAESF---PLGTPIQALAFSENGFWFA 228 Query: 287 A-GYDDFNCNVWDALKADRAGVLAG-HDNRVSCLGVTDDGMAVATGS 331 A G + ++D K+ A + V + G +ATG Sbjct: 229 ATGKGTSSVTIFDLRKSGAAAAVKELQTGEVLSISWDYTGQYLATGG 275 Score = 84.0 bits (206), Expect = 9e-17, Method: Composition-based stats. Identities = 32/211 (15%), Positives = 69/211 (32%), Gaps = 11/211 (5%) Query: 46 RTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAY 105 R T + H + + R+L S D + +D T +V + + TCA+ Sbjct: 121 RESATFQTHAGPVTGLAVHPGGRILASVGVDKSFVFYDLETGERVARGYA-DAALTTCAF 179 Query: 106 APSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTT 165 P GN A G +++ T E + F ++ ++G T Sbjct: 180 HPDGNLFAAGTQTGHILVFHTTTLEQAESFPLGT-----PIQALAFSENGFWFAATGKGT 234 Query: 166 --CALWDIE-TGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDA-SAKLWDVREGMCRQT 221 ++D+ +G TG+V+S+S + +G + +++ + Sbjct: 235 SSVTIFDLRKSGAAAAVKELQTGEVLSISWDYTGQYLATGGGTGVTVQMYTKATKSWSEP 294 Query: 222 FTGHESDINAICFFPNGNAFATGSDDATCRL 252 + + + S + + Sbjct: 295 VRLGM-PVVGVKWGGEAKRLVVVSREGVVSV 324 Score = 48.9 bits (115), Expect = 3e-06, Method: Composition-based stats. Identities = 19/99 (19%), Positives = 38/99 (38%), Gaps = 7/99 (7%) Query: 242 ATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALK 301 A G D ++ + A++ T +I +T+ ++ G ++ G V+DA Sbjct: 67 AVGGLDGKLDIYSVVANKVERTL---DIGEPVTATEWT--GTKVVIGTAKGWVKVYDA-- 119 Query: 302 ADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 + H V+ L V G +A+ D ++ Sbjct: 120 GRESATFQTHAGPVTGLAVHPGGRILASVGVDKSFVFYD 158 >5N4A-A nrPDB Length = 771 Score = 120 bits (301), Expect = 9e-28, Method: Composition-based stats. Identities = 46/286 (16%), Positives = 92/286 (32%), Gaps = 25/286 (8%) Query: 54 HLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGN--- 110 H A+ W + L + S D + W+ + ++ + P + Sbjct: 13 HSELTAAVGWNVWNE-LFTCSDDQTIHKWNML-GEPEQKVSTLDAYFTDMHWYPVSSKKT 70 Query: 111 ------YVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFL-DDNQIVTSSGD 163 A D I + RV + + GH G R+ D + T+ D Sbjct: 71 QAGGTDVFAVACTDGSVKILS-----RTGRVEKSIEGHKGACISLRWSYDGTALATAGED 125 Query: 164 TTCALWDIETGQQTTTFTGHTGDVMSLSLA-PDTRLFVSGACDASAKLWDVREGMCRQTF 222 + +W G +T V S+ A +L + K + + + Sbjct: 126 GSVKIWS-RNGMLRSTLAQADSPVYSIVWAYDCDQLCYCTGSNVVIK--SLSSNAKQNAW 182 Query: 223 TGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSG 282 H+ + + + P + TG +D +++D + + +TSV+++ SG Sbjct: 183 KAHDGVVLKVDWSPINHLIITGGEDCKYKVWD---SFGRLLFQSGLFDYPVTSVAWAPSG 239 Query: 283 RLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVA 328 L G + D + + + + L T D +A Sbjct: 240 ELFAVGGF-NTLQLCDRMGWAYSKIHLNDTGSIMTLSWTADSTQLA 284 Score = 100 bits (250), Expect = 8e-22, Method: Composition-based stats. Identities = 36/208 (17%), Positives = 73/208 (35%), Gaps = 15/208 (7%) Query: 142 HTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAP------- 194 H+ + + N++ T S D T W++ G+ + + P Sbjct: 13 HSELTAAVGWNVWNELFTCSDDQTIHKWNML-GEPEQKVSTLDAYFTDMHWYPVSSKKTQ 71 Query: 195 --DTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRL 252 T +F D S K+ R G ++ GH+ ++ + +G A AT +D + ++ Sbjct: 72 AGGTDVFAVACTDGSVKILS-RTGRVEKSIEGHKGACISLRWSYDGTALATAGEDGSVKI 130 Query: 253 FDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHD 312 + R T + + + S+ ++ L N + + HD Sbjct: 131 WS-RNGMLRSTLAQAD--SPVYSIVWAYDCDQLCYCTG-SNVVIKSLSSNAKQNAWKAHD 186 Query: 313 NRVSCLGVTDDGMAVATGSWDSFLKIWN 340 V + + + TG D K+W+ Sbjct: 187 GVVLKVDWSPINHLIITGGEDCKYKVWD 214 Score = 94.4 bits (233), Expect = 6e-20, Method: Composition-based stats. Identities = 38/200 (19%), Positives = 71/200 (35%), Gaps = 13/200 (6%) Query: 46 RTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAY 105 R +++ GH ++ W D L +A +DG + IW + S V + + Sbjct: 95 RVEKSIEGHKGACISLRWSYDGTALATAGEDGSVKIWS-RNGMLRSTLAQADSPVYSIVW 153 Query: 106 APSGNYV-ACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQ-IVTSSGD 163 A + + C G + + + ++ + H G + + N I+T D Sbjct: 154 AYDCDQLCYCTGSNVVIKSLSSNAKQNAWK------AHDGVVLKVDWSPINHLIITGGED 207 Query: 164 TTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFT 223 +WD G+ V S++ AP LF G + + +L D R G Sbjct: 208 CKYKVWD-SFGRLLFQSGLFDYPVTSVAWAPSGELFAVGGFN-TLQLCD-RMGWAYSKIH 264 Query: 224 GH-ESDINAICFFPNGNAFA 242 + I + + + A Sbjct: 265 LNDTGSIMTLSWTADSTQLA 284 Score = 29.7 bits (65), Expect = 2.1, Method: Composition-based stats. Identities = 16/94 (17%), Positives = 32/94 (34%), Gaps = 9/94 (9%) Query: 164 TTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDV-REGMCRQTF 222 TT +D G+ HT +V ++L+ + D + D R+ Sbjct: 439 TTVRFFDTAQGRPVGEPWQHTLEVKEIALSQAGTI-----NDRQLIVIDRNRDLYLLPVM 493 Query: 223 TGHESDINAICFFP---NGNAFATGSDDATCRLF 253 H + + A+C + A + D ++ Sbjct: 494 KRHVAKLAAMCDSARWHDSTAMLSAMVDQRLCVW 527 >3ACP-A nrPDB Length = 417 Score = 117 bits (292), Expect = 9e-27, Method: Composition-based stats. Identities = 47/261 (18%), Positives = 92/261 (35%), Gaps = 30/261 (11%) Query: 105 YAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDT 164 + G+++ LD ++N R+G+ + R L + + + + Sbjct: 61 FEKVGSHLYKARLDGHDFLFNTIIRDGSKMLKRA----DYTAVDTAKLQMRRFILGTTEG 116 Query: 165 TCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTG 224 + D Q H ++ L P +S + D K+W V++G +T G Sbjct: 117 DIKVLDSNFNLQREIDQAHVSEITKLKFFPSGEALISSSQDMQLKIWSVKDGSNPRTLIG 176 Query: 225 HESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYS-HDNIICGITSVS------ 277 H + + I G + S D T RL++ + T++ +N G+ S++ Sbjct: 177 HRATVTDIAIIDRGRNVLSASLDGTIRLWECGTGTTIHTFNRKENPHDGVNSIALFVGTD 236 Query: 278 ---------------FSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTD 322 F G+ ++AG+ V + ++ L SC +T Sbjct: 237 RQLHEISTSKKNNLEFGTYGKYVIAGHVSGVITVHNVFSKEQTIQLPSKFTC-SCNSLTV 295 Query: 323 DG---MAVATGSWDSFLKIWN 340 DG + G + L W+ Sbjct: 296 DGNNANYIYAGYENGMLAQWD 316 Score = 98.2 bits (243), Expect = 5e-21, Method: Composition-based stats. Identities = 40/244 (16%), Positives = 87/244 (35%), Gaps = 33/244 (13%) Query: 125 NLKTREGNVRVSREL-AGHTGYLSCCRFLDDNQ-IVTSSGDTTCALWDIETGQQTTTFTG 182 ++K + N + RE+ H ++ +F + +++SS D +W ++ G T G Sbjct: 117 DIKVLDSNFNLQREIDQAHVSEITKLKFFPSGEALISSSQDMQLKIWSVKDGSNPRTLIG 176 Query: 183 HTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFT----GHESDINAIC----- 233 H V +++ R +S + D + +LW+ G TF H +N+I Sbjct: 177 HRATVTDIAIIDRGRNVLSASLDGTIRLWECGTGTTIHTFNRKENPH-DGVNSIALFVGT 235 Query: 234 ----------------FFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVS 277 F G G + ++ + ++ + C S++ Sbjct: 236 DRQLHEISTSKKNNLEFGTYGKYVIAGHVSGVITVHNVFSKEQTIQLPSK-FTCSCNSLT 294 Query: 278 FS-KSGRLLLAGYDDFNCNVWDALKADRA--GVLAGHDNRVSCLGVTDDGMAVATGSWDS 334 + + AGY++ WD + L ++ + G + +D+ Sbjct: 295 VDGNNANYIYAGYENGMLAQWDLRSPECPVGEFLINEGTPINNVYFAA-GALFVSSGFDT 353 Query: 335 FLKI 338 +K+ Sbjct: 354 SIKL 357 Score = 92.4 bits (228), Expect = 2e-19, Method: Composition-based stats. Identities = 44/248 (17%), Positives = 81/248 (32%), Gaps = 26/248 (10%) Query: 30 LSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNK 89 L +I + R + H+++I + + L+S+SQD +L IW + Sbjct: 111 LGTTEGDIKVLDSNFNLQREIDQAHVSEITKLKFFPSGEALISSSQDMQLKIWSVKDGSN 170 Query: 90 VHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCC 149 + + V A G V LD ++ T +R+ H G S Sbjct: 171 PRTLIGHRATVTDIAIIDRGRNVLSASLDGTIRLWECGTGTTIHTFNRKENPHDGVNSIA 230 Query: 150 RFLD---------------------DNQIVTSSGDTTCALWDIETGQQTTTFTGH-TGDV 187 F+ ++ + ++ + +QT T Sbjct: 231 LFVGTDRQLHEISTSKKNNLEFGTYGKYVIAGHVSGVITVHNVFSKEQTIQLPSKFTCSC 290 Query: 188 MSLSLAPDT-RLFVSGACDASAKLWDVREGMC-RQTFTGHES-DINAICFFPNGNAFATG 244 SL++ + +G + WD+R C F +E IN + F G F + Sbjct: 291 NSLTVDGNNANYIYAGYENGMLAQWDLRSPECPVGEFLINEGTPINNVYFAA-GALFVSS 349 Query: 245 SDDATCRL 252 D + +L Sbjct: 350 GFDTSIKL 357 >4G56-B nrPDB Length = 357 Score = 114 bits (286), Expect = 5e-26, Method: Composition-based stats. Identities = 48/224 (21%), Positives = 86/224 (38%), Gaps = 9/224 (4%) Query: 122 SIYNLKTREGNVRVSRELAG--HTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTT 179 SI+ K EG S AG ++ ++ + I+ +S LW+I + Sbjct: 71 SIWVFKDPEGAPNESLCTAGVQTEAGVTDVAWVSEKGILVASDSGAVELWEILEKESLLV 130 Query: 180 FTG----HTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFF 235 H V +LS+ D VSG D S K+WD+ + +++ H S++N + Sbjct: 131 NKFAKYEHDDIVKTLSVFSDGTQAVSGGKDFSVKVWDLSQKAVLKSYNAHSSEVNCVAAC 190 Query: 236 PNGN-AFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKS-GRLLLAGYDDFN 293 P + F + +D L+D R + TSV++ G + N Sbjct: 191 PGKDTIFLSCGEDGRILLWDTRKPKPATRIDFCASDTIPTSVTWHPEKDDTFACGDETGN 250 Query: 294 CNVWDALKADRAGVLAGHDNRVSCLGVTDDGM-AVATGSWDSFL 336 ++ + D A A H ++ L + +A+ S D + Sbjct: 251 VSLVNIKNPDSAQTSAVHSQNITGLAYSYHSSPFLASISEDCTV 294 Score = 101 bits (252), Expect = 4e-22, Method: Composition-based stats. Identities = 44/236 (18%), Positives = 84/236 (35%), Gaps = 18/236 (7%) Query: 55 LAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKV----HAIPLRSSWVMTCAYAPSGN 110 A + + W ++ +LV AS G + +W+ + A V T + G Sbjct: 94 EAGVTDVAWVSEKGILV-ASDSGAVELWEILEKESLLVNKFAKYEHDDIVKTLSVFSDGT 152 Query: 111 YVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQ--IVTSSGDTTCAL 168 GG D +++L V + H+ ++C ++ D L Sbjct: 153 QAVSGGKDFSVKVWDLS----QKAVLKSYNAHSSEVNCVAACPGKDTIFLSCGEDGRILL 208 Query: 169 WDIETGQQTTTFTGHTGDV--MSLSLAPD-TRLFVSGACDASAKLWDVREGMCRQTFTGH 225 WD + T D S++ P+ F G + L +++ QT H Sbjct: 209 WDTRKPKPATRIDFCASDTIPTSVTWHPEKDDTFACGDETGNVSLVNIKNPDSAQTSAVH 268 Query: 226 ESDINAICFFPNGN-AFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSK 280 +I + + + + A+ S+D T + D + SH + +T V++S Sbjct: 269 SQNITGLAYSYHSSPFLASISEDCTVAVLDADFSEVFRDLSHRDF---VTGVAWSP 321 Score = 67.4 bits (163), Expect = 8e-12, Method: Composition-based stats. Identities = 22/121 (18%), Positives = 47/121 (38%), Gaps = 10/121 (8%) Query: 226 ESDINAICFFPNGNAFATGSDDATCRLFDLRADQELM-----TYSHDNIICGITSVSFSK 280 E+ + + + SD L+++ + L+ Y HD+I+ ++ S Sbjct: 94 EAGVTDVAWVSEKGILV-ASDSGAVELWEILEKESLLVNKFAKYEHDDIVKTLSVFS--- 149 Query: 281 SGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVA-TGSWDSFLKIW 339 G ++G DF+ VWD + H + V+C+ + + D + +W Sbjct: 150 DGTQAVSGGKDFSVKVWDLSQKAVLKSYNAHSSEVNCVAACPGKDTIFLSCGEDGRILLW 209 Query: 340 N 340 + Sbjct: 210 D 210 Score = 42.0 bits (97), Expect = 4e-04, Method: Composition-based stats. Identities = 21/99 (21%), Positives = 39/99 (39%), Gaps = 7/99 (7%) Query: 248 ATCRLFDLRADQELMTYSHDNIIC--GITSVSFSKSGRLLLAGYDDFNCNVWDALKADRA 305 + +F + + G+T V++ +L+A D +W+ L+ + Sbjct: 70 GSIWVFKDPEGAPNESLCTAGVQTEAGVTDVAWVSEKGILVA-SDSGAVELWEILEKESL 128 Query: 306 GVLA----GHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 V HD+ V L V DG +G D +K+W+ Sbjct: 129 LVNKFAKYEHDDIVKTLSVFSDGTQAVSGGKDFSVKVWD 167 Score = 38.9 bits (89), Expect = 0.003, Method: Composition-based stats. Identities = 17/90 (18%), Positives = 33/90 (36%), Gaps = 3/90 (3%) Query: 34 TNNIDPVGRIQMRTRRTLRGHLAKIYAMHWG-TDSRLLVSASQDGKLIIWDSYTTNKVHA 92 T N+ V + +T H I + + S L S S+D + + D+ + Sbjct: 248 TGNVSLVNIKNPDSAQTSAVHSQNITGLAYSYHSSPFLASISEDCTVAVLDADFSEVFRD 307 Query: 93 IPLRSSWVMTCAYAP-SGNYVACGGLDNIC 121 + +V A++P + G D+ Sbjct: 308 L-SHRDFVTGVAWSPLDHSKFTTVGWDHKV 336 >5CXB-B nrPDB Length = 369 Score = 112 bits (281), Expect = 2e-25, Method: Composition-based stats. Identities = 53/369 (14%), Positives = 101/369 (27%), Gaps = 67/369 (18%) Query: 36 NIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPL 95 + D + + RGH ++ ++ L + DG + +W+ T +V ++ L Sbjct: 2 SPDELKPFPTVQQTIFRGHEGRVRSVAIDPTGVALATGGDDGTVRVWELLTGRQVWSVKL 61 Query: 96 R-SSWVMTCAYAPSGN---YVACGGLDNICSIYNLKT-----REGNVRVSRELAGHT--- 143 V T + P+ + A G D I + + + + GH Sbjct: 62 NGDEAVNTVRWRPTKDTFILAAAAGEDIFLMIPTHPSVTPALDQASRDILNAGFGHATNG 121 Query: 144 -----------------------------------GYLSCCRFLD-DNQIVTSSGDT--- 164 + + + T S Sbjct: 122 KQQANLPPGKEPPGKWARPGTRLEDEGVLLRITVRSTIKAISWHRRGDHFATVSPSGQRS 181 Query: 165 TCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTG 224 + A+ + F G + S P LF S + +D+++ + Sbjct: 182 SVAIHTLSKHLTQIPFRKLNGLAQTASFHPLRPLFFVATQ-RSIRCYDLQKLELVKIVQP 240 Query: 225 HESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRL 284 I++ P G+ GS D L+ + I +V F K G Sbjct: 241 GAKWISSFDVHPGGDNLVVGSYDKRL-LWHDLDLSNRPYKTMRFHTEAIRAVRFHKGGLP 299 Query: 285 LLA-GYDDFNCNVWDAL---------KADRAGVLAGHD----NRVSCLGVTDDGMAVATG 330 L A DD + ++ +L GH V + + Sbjct: 300 LFADASDDGSLQIFHGKVPNDQLENPTIVPVKMLKGHKVVNKLGVLDIDWHPREPWCVSA 359 Query: 331 SWDSFLKIW 339 D ++W Sbjct: 360 GADGTARLW 368 Score = 53.9 bits (128), Expect = 1e-07, Method: Composition-based stats. Identities = 24/148 (16%), Positives = 45/148 (30%), Gaps = 14/148 (9%) Query: 35 NNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIW-DSY-TTNKVHA 92 +I ++ + ++ I + LV S D +L +W D + Sbjct: 222 RSIRCYDLQKLELVKIVQPGAKWISSFDVHPGGDNLVVGSYDKRL-LWHDLDLSNRPYKT 280 Query: 93 IPLRSSWVMTCAYAPSG-NYVACGGLDNICSIY-----NLKTREGNVRVSRELAGHT--- 143 + + + + G A D I+ N + + + L GH Sbjct: 281 MRFHTEAIRAVRFHKGGLPLFADASDDGSLQIFHGKVPNDQLENPTIVPVKMLKGHKVVN 340 Query: 144 --GYLSCCRFLDDNQIVTSSGDTTCALW 169 G L + V++ D T LW Sbjct: 341 KLGVLDIDWHPREPWCVSAGADGTARLW 368 >6EM1-m nrPDB Length = 807 Score = 112 bits (281), Expect = 2e-25, Method: Composition-based stats. Identities = 53/346 (15%), Positives = 102/346 (29%), Gaps = 39/346 (11%) Query: 29 TLSQITNNIDPVG--RIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYT 86 S I P +R GH K+ + L + S DG + +W+ T Sbjct: 409 PNSLIPELPSPKDLRPFPIRCSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILT 468 Query: 87 TNKVH------AIPLRSSWVMTCAYAPS---GNYVACGGLDNICSIYNLKTREGNVRVSR 137 +V+ + + P G G + + + + Sbjct: 469 GREVYRTTLIDDEENPDYHIECIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKT 528 Query: 138 ELAGHTGYLSCCRFLDDNQIVTSSGD---------------TTCALWDIETGQQTTTFTG 182 ++ GY + N V +GD A W+ + +Q Sbjct: 529 KIEDGFGYDTFGTVKKSNLEVNENGDGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDIC 588 Query: 183 HT----GDVMSLSLAPDTRLFVSG---ACDASAKLWDVREGMCRQTFTGHESDINAICFF 235 T V LS FV+ + + S + V + + + F + I F Sbjct: 589 ITISCKKTVKKLSWHRKGDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFH 648 Query: 236 PNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCN 295 P S R++DL Q+++ ++ + G L+A D Sbjct: 649 PFKPQLFVCSQ-RYVRIYDL--SQQILVKKLLPGARWLSKIDIHPRGDNLIASSFDKRV- 704 Query: 296 VWD--ALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIW 339 +W L + L H+ V + ++ + D + ++ Sbjct: 705 LWHDLDLASTPYKTLRYHEKAVRSVNFHKKLPLFSSAADDGTIHVF 750 Score = 90.5 bits (223), Expect = 1e-18, Method: Composition-based stats. Identities = 43/321 (13%), Positives = 91/321 (28%), Gaps = 42/321 (13%) Query: 58 IYAMHWGTDSR---LLVSASQDGKLII-----WDSYTTNKVHAIPLRSSWVMTCAYAPSG 109 I + W D+ L V+ ++ LI+ +D K + Sbjct: 488 IECIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNL 547 Query: 110 NYVACGGLD-------------NICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQ 156 G D + +N +++ + + + Sbjct: 548 EVNENGDGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHRKGD 607 Query: 157 IVTS----SGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWD 212 + SG+T+ + + + F G +M P + +++D Sbjct: 608 YFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVCSQ-RYVRIYD 666 Query: 213 VREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICG 272 + + + + ++ I P G+ S D L+ + Sbjct: 667 LSQQILVKKLLPGARWLSKIDIHPRGDNLIASSFDKRV-LWHDLDLASTPYKTLRYHEKA 725 Query: 273 ITSVSFSKSGRLLLAGYDDFNCNVWDALKAD---------RAGVLAGHDNRVSCLG---- 319 + SV+F K L + DD +V+ A D L GH ++ LG Sbjct: 726 VRSVNFHKKLPLFSSAADDGTIHVFHATVYDDMMKNPMIVPLKKLTGH-KVINSLGVLDA 784 Query: 320 -VTDDGMAVATGSWDSFLKIW 339 + + D+ ++W Sbjct: 785 IWHPREAWLFSAGADNTARLW 805 Score = 58.9 bits (141), Expect = 3e-09, Method: Composition-based stats. Identities = 34/244 (13%), Positives = 72/244 (29%), Gaps = 42/244 (17%) Query: 134 RVSRELAGHTGYLSCCRFLDDN-QIVTSSGDTTCALWDIETGQQTTTFTGHTGD------ 186 R S AGH G + + T S D T +W+I TG++ T + Sbjct: 428 RCSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYH 487 Query: 187 VMSLSLAPDTRL-FVSGACDASAKL-------WDVREGMCRQTFTGHE----SDINA--I 232 + + PD ++ A + L +D+ + G + + Sbjct: 488 IECIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNL 547 Query: 233 CFFPNGNAFATGSDDA-----------TCRLFDLRADQELMTYSHDNIIC--GITSVSFS 279 NG+ G +D ++ + ++L I C + +S+ Sbjct: 548 EVNENGD----GDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWH 603 Query: 280 KSGRLLLAGYDDF---NCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFL 336 + G + D + + K + + S ++ Sbjct: 604 RKGDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVCSQ-RYV 662 Query: 337 KIWN 340 +I++ Sbjct: 663 RIYD 666 Score = 50.8 bits (120), Expect = 9e-07, Method: Composition-based stats. Identities = 14/92 (15%), Positives = 34/92 (36%), Gaps = 13/92 (14%) Query: 48 RRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTN---------KVHAIPLRSS 98 +TLR H + ++++ L SA+ DG + ++ + + + + Sbjct: 716 YKTLRYHEKAVRSVNFHKKLPLFSSAADDGTIHVFHATVYDDMMKNPMIVPLKKLTGHKV 775 Query: 99 W----VMTCAYAPSGNYVACGGLDNICSIYNL 126 V+ + P ++ G DN ++ Sbjct: 776 INSLGVLDAIWHPREAWLFSAGADNTARLWTT 807 >5FA5-B nrPDB Length = 367 Score = 112 bits (280), Expect = 2e-25, Method: Composition-based stats. Identities = 33/198 (16%), Positives = 76/198 (38%), Gaps = 7/198 (3%) Query: 143 TGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTG----HTGDVMSLSLAPDTRL 198 ++ ++ + I+ +S LW+++ + H V ++S+ Sbjct: 105 EAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQ 164 Query: 199 FVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPN-GNAFATGSDDATCRLFDLRA 257 VSG+ D K+WD+ + + ++ H + + + P+ + F + S+D L+D R Sbjct: 165 AVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRC 224 Query: 258 DQELMTYSHDNIICGITSVSFSK-SGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVS 316 + TS+++ + + G ++ ++ D A H V+ Sbjct: 225 PKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVT 284 Query: 317 CLGVTDD-GMAVATGSWD 333 L + +A+ S D Sbjct: 285 GLVFSPHSVPFLASLSED 302 Score = 101 bits (251), Expect = 5e-22, Method: Composition-based stats. Identities = 40/232 (17%), Positives = 79/232 (34%), Gaps = 10/232 (4%) Query: 112 VACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDN-QIVTSSGDTTCALWD 170 + ++ L E + H +S L Q V+ S D +WD Sbjct: 119 ILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWD 178 Query: 171 IETGQQTTTFTGHTGDVMSLSLAPD-TRLFVSGACDASAKLWDVREGMCRQTFTGHESDI 229 + +++ H V ++ +P +F+S + D LWD R Sbjct: 179 LAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGY 238 Query: 230 --NAICFFPNGN-AFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSG-RLL 285 ++ + P + F G ++ T L D ++ + S +T + FS L Sbjct: 239 LPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCV--LSSAVHSQCVTGLVFSPHSVPFL 296 Query: 286 LAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTD-DGMAVATGSWDSFL 336 + +D + V D+ ++ H + V + + + T WD + Sbjct: 297 ASLSEDCSLAVLDSSLSELFRS-QAHRDFVRDATWSPLNHSLLTTVGWDHQV 347 Score = 99.8 bits (247), Expect = 1e-21, Method: Composition-based stats. Identities = 44/243 (18%), Positives = 84/243 (34%), Gaps = 18/243 (7%) Query: 55 LAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIP----LRSSWVMTCAYAPSGN 110 A + + W + +LV AS G + +W+ + V T + SG Sbjct: 105 EAGVADLTWVGERGILV-ASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGT 163 Query: 111 YVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLD--DNQIVTSSGDTTCAL 168 G D +++L V H ++C D+ ++ S D L Sbjct: 164 QAVSGSKDICIKVWDL----AQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILL 219 Query: 169 WDIETGQQTTTFTGHTGDV--MSLSLAP-DTRLFVSGACDASAKLWDVREGMCRQTFTGH 225 WD + + SL+ P + +FV G + + L D + C + H Sbjct: 220 WDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVH 279 Query: 226 ESDINAICFFPNG-NAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRL 284 + + F P+ A+ S+D + + D + + +H + + ++S Sbjct: 280 SQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQAHRDF---VRDATWSPLNHS 336 Query: 285 LLA 287 LL Sbjct: 337 LLT 339 Score = 91.7 bits (226), Expect = 4e-19, Method: Composition-based stats. Identities = 30/200 (15%), Positives = 65/200 (32%), Gaps = 4/200 (2%) Query: 54 HLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSG-NYV 112 H + + + VS S+D + +WD + + ++ V A +P + Sbjct: 149 HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVF 208 Query: 113 ACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIE 172 DN +++ + + ++ G+ V + T +L D + Sbjct: 209 LSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTK 268 Query: 173 TGQQTTTFTGHTGDVMSLSLAPDT-RLFVSGACDASAKLWDVREGMCRQTFTGHESDINA 231 + + H+ V L +P + S + D S + D ++ H + Sbjct: 269 STSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRS-QAHRDFVRD 327 Query: 232 ICFFP-NGNAFATGSDDATC 250 + P N + T D Sbjct: 328 ATWSPLNHSLLTTVGWDHQV 347 Score = 69.7 bits (169), Expect = 2e-12, Method: Composition-based stats. Identities = 25/121 (20%), Positives = 52/121 (42%), Gaps = 10/121 (8%) Query: 226 ESDINAICFFPNGNAFATGSDDATCRLFDLRADQELM-----TYSHDNIICGITSVSFSK 280 E+ + + + SD L++L ++ L+ Y HD+I+ ++ +S Sbjct: 105 EAGVADLTWVGERGILV-ASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLS--- 160 Query: 281 SGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVA-TGSWDSFLKIW 339 SG ++G D VWD + H +V+C+ + +V + S D+ + +W Sbjct: 161 SGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLW 220 Query: 340 N 340 + Sbjct: 221 D 221 Score = 69.7 bits (169), Expect = 2e-12, Method: Composition-based stats. Identities = 28/179 (15%), Positives = 61/179 (34%), Gaps = 12/179 (6%) Query: 37 IDPVGRIQMRTRRTLRGHLAKIYAMHWGT-DSRLLVSASQDGKLIIWDSYTTNKVHAIPL 95 I Q + R H A++ + + +S S+D ++++WD+ I Sbjct: 174 IKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGC 233 Query: 96 RSSW--VMTCAYAP-SGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFL 152 + + A+ P G + S+ + K+ A H+ ++ F Sbjct: 234 SAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKS----TSCVLSSAVHSQCVTGLVFS 289 Query: 153 DDNQ--IVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAP-DTRLFVSGACDASA 208 + + + S D + A+ D + + H V + +P + L + D Sbjct: 290 PHSVPFLASLSEDCSLAVLDSSLSELFRS-QAHRDFVRDATWSPLNHSLLTTVGWDHQV 347 >6C0F-s nrPDB Length = 807 Score = 112 bits (279), Expect = 3e-25, Method: Composition-based stats. Identities = 53/346 (15%), Positives = 102/346 (29%), Gaps = 39/346 (11%) Query: 29 TLSQITNNIDPVG--RIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYT 86 S I P +R GH K+ + L + S DG + +W+ T Sbjct: 409 PNSLIPELPSPKDLRPFPIRCSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILT 468 Query: 87 TNKVH------AIPLRSSWVMTCAYAPS---GNYVACGGLDNICSIYNLKTREGNVRVSR 137 +V+ + + P G G + + + + Sbjct: 469 GREVYRTTLIDDEENPDYHIECIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKT 528 Query: 138 ELAGHTGYLSCCRFLDDNQIVTSSGD---------------TTCALWDIETGQQTTTFTG 182 ++ GY + N V +GD A W+ + +Q Sbjct: 529 KIEDGFGYDTFGTVKKSNLEVNENGDGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDIC 588 Query: 183 HT----GDVMSLSLAPDTRLFVSG---ACDASAKLWDVREGMCRQTFTGHESDINAICFF 235 T V LS FV+ + + S + V + + + F + I F Sbjct: 589 ITISCKKTVKKLSWHRKGDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFH 648 Query: 236 PNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCN 295 P S R++DL Q+++ ++ + G L+A D Sbjct: 649 PFKPQLFVCSQ-RYVRIYDL--SQQILVKKLLPGARWLSKIDIHPRGDNLIASSFDKRV- 704 Query: 296 VWD--ALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIW 339 +W L + L H+ V + ++ + D + ++ Sbjct: 705 LWHDLDLASTPYKTLRYHEKAVRSVNFHKKLPLFSSAADDGTIHVF 750 Score = 89.7 bits (221), Expect = 1e-18, Method: Composition-based stats. Identities = 43/321 (13%), Positives = 91/321 (28%), Gaps = 42/321 (13%) Query: 58 IYAMHWGTDSR---LLVSASQDGKLII-----WDSYTTNKVHAIPLRSSWVMTCAYAPSG 109 I + W D+ L V+ ++ LI+ +D K + Sbjct: 488 IECIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNL 547 Query: 110 NYVACGGLD-------------NICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQ 156 G D + +N +++ + + + Sbjct: 548 EVNENGDGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHRKGD 607 Query: 157 IVTS----SGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWD 212 + SG+T+ + + + F G +M P + +++D Sbjct: 608 YFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVCSQ-RYVRIYD 666 Query: 213 VREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICG 272 + + + + ++ I P G+ S D L+ + Sbjct: 667 LSQQILVKKLLPGARWLSKIDIHPRGDNLIASSFDKRV-LWHDLDLASTPYKTLRYHEKA 725 Query: 273 ITSVSFSKSGRLLLAGYDDFNCNVWDALKAD---------RAGVLAGHDNRVSCLG---- 319 + SV+F K L + DD +V+ A D L GH ++ LG Sbjct: 726 VRSVNFHKKLPLFSSAADDGTIHVFHATVYDDMMKNPMIVPLKKLTGH-KVINSLGVLDA 784 Query: 320 -VTDDGMAVATGSWDSFLKIW 339 + + D+ ++W Sbjct: 785 IWHPREAWLFSAGADNTARLW 805 Score = 58.5 bits (140), Expect = 4e-09, Method: Composition-based stats. Identities = 34/244 (13%), Positives = 72/244 (29%), Gaps = 42/244 (17%) Query: 134 RVSRELAGHTGYLSCCRFLDDN-QIVTSSGDTTCALWDIETGQQTTTFTGHTGD------ 186 R S AGH G + + T S D T +W+I TG++ T + Sbjct: 428 RCSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYH 487 Query: 187 VMSLSLAPDTRL-FVSGACDASAKL-------WDVREGMCRQTFTGHE----SDINA--I 232 + + PD ++ A + L +D+ + G + + Sbjct: 488 IECIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNL 547 Query: 233 CFFPNGNAFATGSDDA-----------TCRLFDLRADQELMTYSHDNIIC--GITSVSFS 279 NG+ G +D ++ + ++L I C + +S+ Sbjct: 548 EVNENGD----GDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWH 603 Query: 280 KSGRLLLAGYDDF---NCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFL 336 + G + D + + K + + S ++ Sbjct: 604 RKGDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVCSQ-RYV 662 Query: 337 KIWN 340 +I++ Sbjct: 663 RIYD 666 Score = 50.5 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 14/92 (15%), Positives = 34/92 (36%), Gaps = 13/92 (14%) Query: 48 RRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTN---------KVHAIPLRSS 98 +TLR H + ++++ L SA+ DG + ++ + + + + Sbjct: 716 YKTLRYHEKAVRSVNFHKKLPLFSSAADDGTIHVFHATVYDDMMKNPMIVPLKKLTGHKV 775 Query: 99 W----VMTCAYAPSGNYVACGGLDNICSIYNL 126 V+ + P ++ G DN ++ Sbjct: 776 INSLGVLDAIWHPREAWLFSAGADNTARLWTT 807 >6CB1-s nrPDB Length = 569 Score = 112 bits (279), Expect = 3e-25, Method: Composition-based stats. Identities = 53/346 (15%), Positives = 102/346 (29%), Gaps = 39/346 (11%) Query: 29 TLSQITNNIDPVG--RIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYT 86 S I P +R GH K+ + L + S DG + +W+ T Sbjct: 171 PNSLIPELPSPKDLRPFPIRCSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILT 230 Query: 87 TNKVH------AIPLRSSWVMTCAYAPS---GNYVACGGLDNICSIYNLKTREGNVRVSR 137 +V+ + + P G G + + + + Sbjct: 231 GREVYRTTLIDDEENPDYHIECIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKT 290 Query: 138 ELAGHTGYLSCCRFLDDNQIVTSSGD---------------TTCALWDIETGQQTTTFTG 182 ++ GY + N V +GD A W+ + +Q Sbjct: 291 KIEDGFGYDTFGTVKKSNLEVNENGDGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDIC 350 Query: 183 HT----GDVMSLSLAPDTRLFVSG---ACDASAKLWDVREGMCRQTFTGHESDINAICFF 235 T V LS FV+ + + S + V + + + F + I F Sbjct: 351 ITISCKKTVKKLSWHRKGDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFH 410 Query: 236 PNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCN 295 P S R++DL Q+++ ++ + G L+A D Sbjct: 411 PFKPQLFVCSQ-RYVRIYDL--SQQILVKKLLPGARWLSKIDIHPRGDNLIASSFDKRV- 466 Query: 296 VWD--ALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIW 339 +W L + L H+ V + ++ + D + ++ Sbjct: 467 LWHDLDLASTPYKTLRYHEKAVRSVNFHKKLPLFSSAADDGTIHVF 512 Score = 89.7 bits (221), Expect = 2e-18, Method: Composition-based stats. Identities = 32/239 (13%), Positives = 72/239 (30%), Gaps = 21/239 (8%) Query: 119 NICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTS----SGDTTCALWDIETG 174 + +N +++ + + + + SG+T+ + + Sbjct: 332 KQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHRKGDYFVTVQPDSGNTSVLIHQVSKH 391 Query: 175 QQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICF 234 + F G +M P + +++D+ + + + ++ I Sbjct: 392 LTQSPFKKSKGIIMDAKFHPFKPQLFVCSQ-RYVRIYDLSQQILVKKLLPGARWLSKIDI 450 Query: 235 FPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNC 294 P G+ S D L+ + + SV+F K L + DD Sbjct: 451 HPRGDNLIASSFDKRV-LWHDLDLASTPYKTLRYHEKAVRSVNFHKKLPLFSSAADDGTI 509 Query: 295 NVWDALKAD---------RAGVLAGHDNRVSCLG-----VTDDGMAVATGSWDSFLKIW 339 +V+ A D L GH ++ LG + + D+ ++W Sbjct: 510 HVFHATVYDDMMKNPMIVPLKKLTGH-KVINSLGVLDAIWHPREAWLFSAGADNTARLW 567 Score = 84.4 bits (207), Expect = 7e-17, Method: Composition-based stats. Identities = 27/240 (11%), Positives = 69/240 (28%), Gaps = 23/240 (9%) Query: 77 GKLIIWDSYTTNKVHA----IPLRSSWVMTCAYAPSGNYVACGGLDN---ICSIYNLKTR 129 ++ W+ + ++ V ++ G+Y D+ I+ + Sbjct: 332 KQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHRKGDYFVTVQPDSGNTSVLIHQVSKH 391 Query: 130 EGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMS 189 + G + +F + ++D+ + Sbjct: 392 LTQSPFKKS----KGIIMDAKFHPFKPQLFVCSQRYVRIYDLSQQILVKKLLPGARWLSK 447 Query: 190 LSLAPDTRLFVSGACDASAKLWDVR-EGMCRQTFTGHESDINAICFFPNGNAFATGSDDA 248 + + P ++ + D D+ +T HE + ++ F F++ +DD Sbjct: 448 IDIHPRGDNLIASSFDKRVLWHDLDLASTPYKTLRYHEKAVRSVNFHKKLPLFSSAADDG 507 Query: 249 TCRLF------DLRADQELMTYSHDNIICGITSVS-----FSKSGRLLLAGYDDFNCNVW 297 T +F D+ + ++ I S+ + L + D +W Sbjct: 508 TIHVFHATVYDDMMKNPMIVPLKKLTGHKVINSLGVLDAIWHPREAWLFSAGADNTARLW 567 Score = 58.5 bits (140), Expect = 4e-09, Method: Composition-based stats. Identities = 34/244 (13%), Positives = 72/244 (29%), Gaps = 42/244 (17%) Query: 134 RVSRELAGHTGYLSCCRFLDDN-QIVTSSGDTTCALWDIETGQQTTTFTGHTGD------ 186 R S AGH G + + T S D T +W+I TG++ T + Sbjct: 190 RCSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYH 249 Query: 187 VMSLSLAPDTRL-FVSGACDASAKL-------WDVREGMCRQTFTGHE----SDINA--I 232 + + PD ++ A + L +D+ + G + + Sbjct: 250 IECIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNL 309 Query: 233 CFFPNGNAFATGSDDA-----------TCRLFDLRADQELMTYSHDNIIC--GITSVSFS 279 NG+ G +D ++ + ++L I C + +S+ Sbjct: 310 EVNENGD----GDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWH 365 Query: 280 KSGRLLLAGYDDF---NCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFL 336 + G + D + + K + + S ++ Sbjct: 366 RKGDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVCSQ-RYV 424 Query: 337 KIWN 340 +I++ Sbjct: 425 RIYD 428 Score = 50.5 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 14/92 (15%), Positives = 34/92 (36%), Gaps = 13/92 (14%) Query: 48 RRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTN---------KVHAIPLRSS 98 +TLR H + ++++ L SA+ DG + ++ + + + + Sbjct: 478 YKTLRYHEKAVRSVNFHKKLPLFSSAADDGTIHVFHATVYDDMMKNPMIVPLKKLTGHKV 537 Query: 99 W----VMTCAYAPSGNYVACGGLDNICSIYNL 126 V+ + P ++ G DN ++ Sbjct: 538 INSLGVLDAIWHPREAWLFSAGADNTARLWTT 569 >5WLC-LW nrPDB Length = 554 Score = 109 bits (271), Expect = 2e-24, Method: Composition-based stats. Identities = 48/243 (19%), Positives = 93/243 (38%), Gaps = 14/243 (5%) Query: 61 MHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNI 120 + + + L+ + G + D + L + + Y + Y A Sbjct: 116 IKYAKNGTHLLITGRKGHVASMDWRKGQLRAELFLNET-CHSATYLQNEQYFAVAQKKYT 174 Query: 121 CSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGD-TTCALWDIETGQQTTT 179 IY+ + E + A H FL + ++ ++G+ D+ TGQ + Sbjct: 175 -FIYDHEGTELHRLKQHIEARH------LDFLPYHYLLVTAGETGWLKYHDVSTGQLVSE 227 Query: 180 FTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGN 239 G M+++ P + G + + LW +N+I +G Sbjct: 228 LRTKAGPTMAMAQNPWNAVMHLGHSNGTVSLWSPSMPEPLVKLLSARGPVNSIAIDRSGY 287 Query: 240 AFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVW-D 298 AT D + +++D+R ++L +S +++ T+VS S +G LLA + +W D Sbjct: 288 YMATTGADRSMKIWDIRNFKQL--HSVESLPTPGTNVSISDTG--LLALSRGPHVTLWKD 343 Query: 299 ALK 301 ALK Sbjct: 344 ALK 346 Score = 73.2 bits (178), Expect = 2e-13, Method: Composition-based stats. Identities = 27/189 (14%), Positives = 57/189 (30%), Gaps = 8/189 (4%) Query: 153 DDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWD 212 + ++ + A D GQ S + + + F + ++D Sbjct: 121 NGTHLLITGRKGHVASMDWRKGQLRAEL-FLNETCHSATYLQNEQYFAVAQKKYTF-IYD 178 Query: 213 VREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTY-SHDNIIC 271 EG H + F P T + + D+ Q + + Sbjct: 179 -HEGTELHRLKQHIEA-RHLDFLPYHYLLVTAGETGWLKYHDVSTGQLVSELRTKAGPTM 236 Query: 272 GITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGS 331 + ++ L G+ + ++W + L V+ + + G +AT Sbjct: 237 AMAQNPWNAVMHL---GHSNGTVSLWSPSMPEPLVKLLSARGPVNSIAIDRSGYYMATTG 293 Query: 332 WDSFLKIWN 340 D +KIW+ Sbjct: 294 ADRSMKIWD 302 Score = 42.4 bits (98), Expect = 3e-04, Method: Composition-based stats. Identities = 20/124 (16%), Positives = 39/124 (31%), Gaps = 5/124 (4%) Query: 46 RTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAY 105 + LR AM + ++ +G + +W + + V + A Sbjct: 223 QLVSELRTKAGPTMAMAQNPWNAVMHLGHSNGTVSLWSPSMPEPLVKLLSARGPVNSIAI 282 Query: 106 APSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTT 165 SG Y+A G D I++++ N + + + D + S Sbjct: 283 DRSGYYMATTGADRSMKIWDIR----NFKQLHSVESLPTPGTNVSISDTGLLAL-SRGPH 337 Query: 166 CALW 169 LW Sbjct: 338 VTLW 341 >5WLC-LN nrPDB Length = 776 Score = 107 bits (266), Expect = 1e-23, Method: Composition-based stats. Identities = 52/314 (16%), Positives = 98/314 (31%), Gaps = 32/314 (10%) Query: 53 GHLAKIYAMHWGT---DSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109 G I + W +S L S + WD T + S + + + S Sbjct: 94 GKDRSIEGLCWSNVNGESLRLFSIGGSTVVTEWDLATGLPLRNYDCNSGVIWSISINDSQ 153 Query: 110 NYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALW 169 + ++ G + + ++ G + L + + D+ ++ D +W Sbjct: 154 DKLSVGCDNGTVVLIDISGGPGVLEHDTILMRQEARVLTLAWKKDDFVIGGCSDGRIRIW 213 Query: 170 DIETGQQTTTFTGHTGD----------VMSLSLAPDTRLFVSGACDASAKLWDVREGMCR 219 + + HT V S+ P T SG S K WD + Sbjct: 214 SAQKNDENMGRLLHTMKVDKAKKESTLVWSVIYLPRTDQIASGDSTGSIKFWDFQFATLN 273 Query: 220 QTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELM---------TYSHDNII 270 Q+F H++D+ + + N + D F ++ H N I Sbjct: 274 QSFKAHDADVLCLTTDTDNNYVFSAGVDRKIFQFSQNTNKSQKNNRWVNSSNRLLHGNDI 333 Query: 271 CGITSVSFSKSGRLLLAGYDDFNCNV-----WDALKADRAGVLAGHDNRVSCLGVTDDGM 325 I + SK L++G + + + + + + V V + Sbjct: 334 RAICAYQ-SKGADFLVSGGVEKTLVINSLTSFSNGNYRKMPTVEPYSKNVL---VNKEQR 389 Query: 326 AVATGSWDSFLKIW 339 V + S S +KIW Sbjct: 390 LVVSWSE-STVKIW 402 Score = 74.0 bits (180), Expect = 8e-14, Method: Composition-based stats. Identities = 29/217 (13%), Positives = 68/217 (31%), Gaps = 19/217 (8%) Query: 141 GHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETG--QQTTTFTGHTGDVMSLSL---APD 195 H ++ D ++ + +W+ Q+ G + L + Sbjct: 52 SHKSNINKLTPS-DLRLAIGRSNGNIEIWNPRNNWFQEMVIEGGKDRSIEGLCWSNVNGE 110 Query: 196 TRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDL 255 + S WD+ G+ + + + I +I + + + G D+ T L D+ Sbjct: 111 SLRLFSIGGSTVVTEWDLATGLPLRNYDCNSGVIWSISINDSQDKLSVGCDNGTVVLIDI 170 Query: 256 RADQELMTYSH--DNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKAD---------- 303 ++ + + ++++ K ++ G D +W A K D Sbjct: 171 SGGPGVLEHDTILMRQEARVLTLAWKKD-DFVIGGCSDGRIRIWSAQKNDENMGRLLHTM 229 Query: 304 RAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 + V + +A+G +K W+ Sbjct: 230 KVDKAKKESTLVWSVIYLPRTDQIASGDSTGSIKFWD 266 Score = 50.1 bits (118), Expect = 1e-06, Method: Composition-based stats. Identities = 30/175 (17%), Positives = 63/175 (36%), Gaps = 22/175 (12%) Query: 47 TRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIP--------LRSS 98 ++ + H A + + TD+ + SA D K+ + T L + Sbjct: 272 LNQSFKAHDADVLCLTTDTDNNYVFSAGVDRKIFQFSQNTNKSQKNNRWVNSSNRLLHGN 331 Query: 99 WVMTCAY--APSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQ 156 + + +++ GG++ I +L + R++ Y + + Sbjct: 332 DIRAICAYQSKGADFLVSGGVEKTLVINSLTSFSNGN--YRKMPTVEPYSKNVLVNKEQR 389 Query: 157 IVTSSGDTTCALW----DIETGQ-----QTTTFTGHTGDVMSLSLAPDTRLFVSG 202 +V S ++T +W D T Q T ++ + SL+PD ++ V G Sbjct: 390 LVVSWSESTVKIWTMGTDSSTEQNYKLVCKLTLKD-DQNISTCSLSPDGQVLVVG 443 >2PM9-A nrPDB Length = 416 Score = 102 bits (255), Expect = 2e-22, Method: Composition-based stats. Identities = 50/318 (15%), Positives = 111/318 (34%), Gaps = 43/318 (13%) Query: 61 MHWGTDS-RLLVSA----------SQDGKLIIWDS---YTTNKVHAIPLRSSWVMTCAYA 106 W D LLVS S D L +W + + ++ + S ++ Sbjct: 18 FAWSHDKIPLLVSGTVSGTVDANFSTDSSLELWSLLAADSEKPIASLQV-DSKFNDLDWS 76 Query: 107 PSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFL--DDNQIVTSSGDT 164 + +A + +Y+ + + H+ + +F DN + + + Sbjct: 77 HNNKIIAGALDNGSLELYSTNEANNAINSMARFSNHSSSVKTVKFNAKQDNVLASGGNNG 136 Query: 165 TCALWDIETGQQTTTFTGHT-----------GDVMSLSLAPD-TRLFVSGACDASAKLWD 212 +WD+ + T + + +T +V+SL+ +F S A +WD Sbjct: 137 EIFIWDMN--KCTESPSNYTPLTPGQSMSSVDEVISLAWNQSLAHVFASAGSSNFASIWD 194 Query: 213 VREGMCRQTF------TGHESDINAICFFP-NGNAFATGSD---DATCRLFDLRADQELM 262 ++ +G + ++ + + P N AT + D + ++DLR + Sbjct: 195 LKAKKEVIHLSYTSPNSGIKQQLSVVEWHPKNSTRVATATGSDNDPSILIWDLRNANTPL 254 Query: 263 TYSHDNIICGITSVSF-SKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVT 321 + GI S+ + + LLL+ D +W+ A++ N Sbjct: 255 QTLNQGHQKGILSLDWCHQDEHLLLSSGRDNTVLLWNPESAEQLSQFPARGNWCFKTKFA 314 Query: 322 DDGMAVATG-SWDSFLKI 338 + + S+D+ +++ Sbjct: 315 PEAPDLFACASFDNKIEV 332 Score = 93.6 bits (231), Expect = 1e-19, Method: Composition-based stats. Identities = 43/273 (15%), Positives = 97/273 (35%), Gaps = 29/273 (10%) Query: 95 LRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDD 154 + + SG A D+ +++L + + L + + + + + Sbjct: 21 SHDKIPLLVSGTVSGTVDANFSTDSSLELWSLLAADSE-KPIASLQVDSKF-NDLDWSHN 78 Query: 155 NQIVTSSGDT-TCALWDIETGQ----QTTTFTGHTGDVMSLSLA-PDTRLFVSGACDASA 208 N+I+ + D + L+ F+ H+ V ++ + SG + Sbjct: 79 NKIIAGALDNGSLELYSTNEANNAINSMARFSNHSSSVKTVKFNAKQDNVLASGGNNGEI 138 Query: 209 KLWDV----REGMCRQTFTGHE-----SDINAICFFPN-GNAFATGSDDATCRLFDLRAD 258 +WD+ T + ++ ++ + + + FA+ ++DL+A Sbjct: 139 FIWDMNKCTESPSNYTPLTPGQSMSSVDEVISLAWNQSLAHVFASAGSSNFASIWDLKAK 198 Query: 259 QELMTYSHDNIICGITS----VSFSKSGRLLLA---GYD-DFNCNVWDALKAD-RAGVLA 309 +E++ S+ + GI V + +A G D D + +WD A+ L Sbjct: 199 KEVIHLSYTSPNSGIKQQLSVVEWHPKNSTRVATATGSDNDPSILIWDLRNANTPLQTLN 258 Query: 310 -GHDNRVSCLGV-TDDGMAVATGSWDSFLKIWN 340 GH + L D + + D+ + +WN Sbjct: 259 QGHQKGILSLDWCHQDEHLLLSSGRDNTVLLWN 291 Score = 88.6 bits (218), Expect = 4e-18, Method: Composition-based stats. Identities = 48/225 (21%), Positives = 85/225 (37%), Gaps = 22/225 (9%) Query: 50 TLRGHLAKIYAMHWG-TDSRLLVSASQDGKLIIWDS-----YTTNKVHAIPLRS----SW 99 H + + + + +L S +G++ IWD +N P +S Sbjct: 108 RFSNHSSSVKTVKFNAKQDNVLASGGNNGEIFIWDMNKCTESPSNYTPLTPGQSMSSVDE 167 Query: 100 VMTCAYAPS-GNYVACGGLDNICSIYNLKTREGNVRVSRE--LAGHTGYLSCCRFLDDN- 155 V++ A+ S + A G N SI++LK ++ + +S +G LS + N Sbjct: 168 VISLAWNQSLAHVFASAGSSNFASIWDLKAKKEVIHLSYTSPNSGIKQQLSVVEWHPKNS 227 Query: 156 -QIVTSSG---DTTCALWDIETGQ-QTTTFT-GHTGDVMSLSL-APDTRLFVSGACDASA 208 ++ T++G D + +WD+ T GH ++SL D L +S D + Sbjct: 228 TRVATATGSDNDPSILIWDLRNANTPLQTLNQGHQKGILSLDWCHQDEHLLLSSGRDNTV 287 Query: 209 KLWDVREGMCRQTFTGHESDINAICFFPN-GNAFATGSDDATCRL 252 LW+ F + F P + FA S D + Sbjct: 288 LLWNPESAEQLSQFPARGNWCFKTKFAPEAPDLFACASFDNKIEV 332 Score = 65.5 bits (158), Expect = 4e-11, Method: Composition-based stats. Identities = 20/83 (24%), Positives = 38/83 (45%), Gaps = 2/83 (2%) Query: 52 RGHLAKIYAMHW-GTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSG- 109 +GH I ++ W D LL+S+ +D +++W+ + ++ P R +W +AP Sbjct: 259 QGHQKGILSLDWCHQDEHLLLSSGRDNTVLLWNPESAEQLSQFPARGNWCFKTKFAPEAP 318 Query: 110 NYVACGGLDNICSIYNLKTREGN 132 + AC DN + L+ Sbjct: 319 DLFACASFDNKIEVQTLQNLTNT 341 >4OWR-A nrPDB Length = 339 Score = 102 bits (254), Expect = 2e-22, Method: Composition-based stats. Identities = 32/130 (24%), Positives = 56/130 (43%), Gaps = 9/130 (6%) Query: 143 TGYLSCCRF----LDDNQIVTSSGDTTCALWDIE-TGQQTTT-FTGHTGDVMSLSLAPDT 196 + C F L N ++ S W+++ +GQ HTG V+ + + D Sbjct: 10 DDSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDG 69 Query: 197 RLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICF--FPNGNAFATGSDDATCRLFD 254 + +CD +AK+WD+ Q H++ + I + PN + TGS D T + +D Sbjct: 70 SKVFTASCDKTAKMWDLSSNQAIQ-IAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWD 128 Query: 255 LRADQELMTY 264 R+ +M Sbjct: 129 TRSSNPMMVL 138 Score = 92.8 bits (229), Expect = 2e-19, Method: Composition-based stats. Identities = 41/317 (12%), Positives = 89/317 (28%), Gaps = 83/317 (26%) Query: 55 LAKIYAMHWGTD---SRLLVSASQDGKLIIWDSYTTNKV--HAIPLRSSWVMTCAYAPSG 109 I + + L++ S + W+ + + A + + V+ ++ G Sbjct: 10 DDSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDG 69 Query: 110 NYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFL---DDNQIVTSSGDTTC 166 + V D +++L + + ++A H + ++ + + ++T S D T Sbjct: 70 SKVFTASCDKTAKMWDLSSNQAI-----QIAQHDAPVKTIHWIKAPNYSCVMTGSWDKTL 124 Query: 167 ALWDIETGQQTTTFT-------------------------------------------GH 183 WD + H Sbjct: 125 KFWDTRSSNPMMVLQLPERCYCADVIYPMAVVATAERGLIVYQLENQPSEFRRIESPLKH 184 Query: 184 TGDVMSLSLAPDTRL---FVSGACDASAKLWDVREGMCRQ---TFTGHES---------- 227 +++ F G+ + + + + TF H S Sbjct: 185 QHRCVAI-FKDKQNKPTGFALGSIEGRVAIHYINPPNPAKDNFTFKCHRSNGTNTSAPQD 243 Query: 228 --DINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLL 285 +N I F P AT D +D A +L T + + I++ F+ +G + Sbjct: 244 IYAVNGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKT--SEQLDQPISACCFNHNGNIF 301 Query: 286 LAGYDDFNCNVWDALKA 302 +D K Sbjct: 302 AYASS------YDWSKG 312 Score = 84.4 bits (207), Expect = 6e-17, Method: Composition-based stats. Identities = 40/276 (14%), Positives = 87/276 (31%), Gaps = 31/276 (11%) Query: 90 VHAIPLRSSWVMTCAYAPS---GNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYL 146 + + +++P GN++ G N + ++ + ++++ HTG + Sbjct: 3 IEVTSSPDDSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQM--HTGPV 60 Query: 147 SCCRFLDDN-QIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSL--APDTRLFVSGA 203 + DD ++ T+S D T +WD+ + Q H V ++ AP+ ++G+ Sbjct: 61 LDVCWSDDGSKVFTASCDKTAKMWDLSSNQAIQ-IAQHDAPVKTIHWIKAPNYSCVMTGS 119 Query: 204 CDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMT 263 D + K WD R E A +P + + ++ L Sbjct: 120 WDKTLKFWDTRSSNPMMVLQLPERCYCADVIYPMA---VVATAERGLIVYQLENQPSEFR 176 Query: 264 YSHDNIICGITSVSFSKSGRL----LLAGYDDFNCNV--WDALKADRAG-VLAGHDNR-- 314 + V+ K + G + + + + H + Sbjct: 177 RIESPLKHQHRCVAIFKDKQNKPTGFALGSIEGRVAIHYINPPNPAKDNFTFKCHRSNGT 236 Query: 315 ----------VSCLGVTDDGMAVATGSWDSFLKIWN 340 V+ + +AT D W+ Sbjct: 237 NTSAPQDIYAVNGIAFHPVHGTLATVGSDGRFSFWD 272 >2P9P-C nrPDB Length = 372 Score = 101 bits (251), Expect = 5e-22, Method: Composition-based stats. Identities = 44/217 (20%), Positives = 76/217 (35%), Gaps = 25/217 (11%) Query: 145 YLSCCRFLDD-NQIVTSSGDTTCALWDIETGQ--QTTTFTGHTGDVMSLSLAPDTRLFVS 201 +SC + D QI + +++ + Q H G V + APD+ V+ Sbjct: 10 PISCHAWNKDRTQIAICPNNHEVHIYEKSGNKWVQVHELKEHNGQVTGVDWAPDSNRIVT 69 Query: 202 GACDASAKLWDVREGMCRQTFTGHES--DINAICFFPNGNAFATGSDDATCRL--FDLRA 257 D +A +W ++ + T + + PN FA GS + F+ Sbjct: 70 CGTDRNAYVWTLKGRTWKPTLVILRINRAARCVRWAPNEKKFAVGSGSRVISICYFEQEN 129 Query: 258 DQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDAL----KADRAGVLAGHD- 312 D + + I + S+ + + LL AG DF C ++ A + A G Sbjct: 130 DWWVCKHIKKPIRSTVLSLDWHPNSVLLAAGSCDFKCRIFSAYIKEVEERPAPTPWGSKM 189 Query: 313 -------------NRVSCLGVTDDGMAVATGSWDSFL 336 V + + +G VA S DS + Sbjct: 190 PFGELMFESSSSCGWVHGVCFSANGSRVAWVSHDSTV 226 Score = 84.4 bits (207), Expect = 7e-17, Method: Composition-based stats. Identities = 47/330 (14%), Positives = 90/330 (27%), Gaps = 55/330 (16%) Query: 49 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDS--YTTNKVHAIPLRSSWVMTCAYA 106 L+ H ++ + W DS +V+ D +W T I + +A Sbjct: 46 HELKEHNGQVTGVDWAPDSNRIVTCGTDRNAYVWTLKGRTWKPTLVILRINRAARCVRWA 105 Query: 107 PSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTS-SGDTT 165 P+ A G + SI + + + ++ ++ + S D Sbjct: 106 PNEKKFAVGSGSRVISICYFEQENDWWVCKHIKKPIRSTVLSLDWHPNSVLLAAGSCDFK 165 Query: 166 CALWD------------------IETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDAS 207 C ++ + G+ + G V + + + + D++ Sbjct: 166 CRIFSAYIKEVEERPAPTPWGSKMPFGELMFESSSSCGWVHGVCFSANGSRVAWVSHDST 225 Query: 208 AKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATG--------SDDATCRLFDLRADQ 259 L D + M T + A+ F + A G + D+ Sbjct: 226 VCLADADKKMAVATLASETLPLLAVTFITESSLVAAGHDCFPVLFTYDSAAGKLSFGGRL 285 Query: 260 ELMTYSHDNIICGITSVSF-----SKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNR 314 ++ S + S G D + H N Sbjct: 286 DVPKQSSQRGLTARERFQNLDKKASSEGSAAAGAGLD-----------------SLHKNS 328 Query: 315 VSCLGVTDDGMA----VATGSWDSFLKIWN 340 VS + V G A T D + IW+ Sbjct: 329 VSQISVLSGGKAKCSQFCTTGMDGGMSIWD 358 Score = 80.9 bits (198), Expect = 7e-16, Method: Composition-based stats. Identities = 45/254 (17%), Positives = 81/254 (31%), Gaps = 25/254 (9%) Query: 100 VMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDD-NQIV 158 + A+ +A ++ IY + EL H G ++ + D N+IV Sbjct: 11 ISCHAWNKDRTQIAICPNNHEVHIYEKSGNK--WVQVHELKEHNGQVTGVDWAPDSNRIV 68 Query: 159 TSSGDTTCALWDI--ETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREG 216 T D +W + T + T + AP+ + F G+ + + Sbjct: 69 TCGTDRNAYVWTLKGRTWKPTLVILRINRAARCVRWAPNEKKFAVGSGSRVISICYFEQE 128 Query: 217 M----CRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFD------------LRADQE 260 C+ S + ++ + PN A GS D CR+F + Sbjct: 129 NDWWVCKHIKKPIRSTVLSLDWHPNSVLLAAGSCDFKCRIFSAYIKEVEERPAPTPWGSK 188 Query: 261 LMT----YSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVS 316 + + + + V FS +G + D + DA K LA + Sbjct: 189 MPFGELMFESSSSCGWVHGVCFSANGSRVAWVSHDSTVCLADADKKMAVATLASETLPLL 248 Query: 317 CLGVTDDGMAVATG 330 + + VA G Sbjct: 249 AVTFITESSLVAAG 262 Score = 78.2 bits (191), Expect = 5e-15, Method: Composition-based stats. Identities = 19/161 (11%), Positives = 47/161 (29%), Gaps = 6/161 (3%) Query: 186 DVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQT--FTGHESDINAICFFPNGNAFAT 243 + + D + +++ Q H + + + P+ N T Sbjct: 10 PISCHAWNKDRTQIAICPNNHEVHIYEKSGNKWVQVHELKEHNGQVTGVDWAPDSNRIVT 69 Query: 244 GSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVW----DA 299 D ++ L+ T I V ++ + + G ++ + Sbjct: 70 CGTDRNAYVWTLKGRTWKPTLVILRINRAARCVRWAPNEKKFAVGSGSRVISICYFEQEN 129 Query: 300 LKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 + + V L + + +A GS D +I++ Sbjct: 130 DWWVCKHIKKPIRSTVLSLDWHPNSVLLAAGSCDFKCRIFS 170 Score = 47.0 bits (110), Expect = 1e-05, Method: Composition-based stats. Identities = 34/224 (15%), Positives = 64/224 (28%), Gaps = 67/224 (29%) Query: 55 LAKIYAMHWGTDSRLLVSASQDGKLIIWDSYT------------------TNKVHAIPLR 96 + + ++ W +S LL + S D K I+ +Y + Sbjct: 142 RSTVLSLDWHPNSVLLAAGSCDFKCRIFSAYIKEVEERPAPTPWGSKMPFGELMFESSSS 201 Query: 97 SSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQ 156 WV ++ +G+ VA D+ + + + LA T L F+ ++ Sbjct: 202 CGWVHGVCFSANGSRVAWVSHDSTVCLADADKK----MAVATLASETLPLLAVTFITESS 257 Query: 157 IVTSSGDTTCALWDIETGQQTTTFTG---------------------------------- 182 +V + D L+ ++ +F G Sbjct: 258 LVAAGHDCFPVLFTYDSAAGKLSFGGRLDVPKQSSQRGLTARERFQNLDKKASSEGSAAA 317 Query: 183 -------HTGDVMSLSLAPDT----RLFVSGACDASAKLWDVRE 215 H V +S+ F + D +WDVR Sbjct: 318 GAGLDSLHKNSVSQISVLSGGKAKCSQFCTTGMDGGMSIWDVRS 361 >3W15-A nrPDB Length = 368 Score = 101 bits (251), Expect = 5e-22, Method: Composition-based stats. Identities = 69/367 (18%), Positives = 123/367 (33%), Gaps = 78/367 (21%) Query: 47 TRRTLRGHLAKIYAMHWGT--DSRLLVSASQD----GKLIIWDSYTTNKVHAIPLRSSWV 100 R ++G Y + + D+RL V+A + G ++ + + S Sbjct: 4 LRYHMQGFSG--YGVQYSPFFDNRLAVAAGSNFGLVGNGKLFILEIDRSGRIVEVNSFLT 61 Query: 101 MTCAYA-----PSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFL--D 153 C + N V D +++ +E + + +E H + C + + Sbjct: 62 QDCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKE---HEREVFSCNWNLVN 118 Query: 154 DNQIVTSSGDTTCALWDIETGQ------------------------QTTTFTGHTGDVMS 189 ++SS D + +W Q + +FTG + + Sbjct: 119 RQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNC 178 Query: 190 L---SLAP-DTRLFVSGACDASAKLWDVR--EGMCRQTFTGHES-DINAICFFP-NGNAF 241 + +P D L +S + ++ A L+D+R G + F H + F Sbjct: 179 VYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVV 238 Query: 242 ATGSDDATCRLFDLR----ADQELMTYSHDNIICG-----ITSVSFSK-SGRLLLAGYDD 291 ATG D R++D+R +L S N I I V++S +L++ D Sbjct: 239 ATGGVDNAIRIWDIRMLNKNPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYD 298 Query: 292 FNCNVWDALKADRAGV----------------LAGHDNRVSCLGVTDDGM--AVATGSWD 333 C +W L D A H V + G VA+ +WD Sbjct: 299 MTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWD 358 Query: 334 SFLKIWN 340 L +WN Sbjct: 359 GNLFVWN 365 >4J0X-A nrPDB Length = 451 Score = 100 bits (250), Expect = 6e-22, Method: Composition-based stats. Identities = 55/318 (17%), Positives = 103/318 (32%), Gaps = 57/318 (17%) Query: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRS--SWVMTCAYAP 107 T GH +I + D + +V+ +D KLI+W + + + V IP + V++ A+ Sbjct: 109 TTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRRGEVLSLAFRK 168 Query: 108 SGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLD-DNQIVTSSGDTTC 166 + + + D Y++ L GH + L + + + D T Sbjct: 169 NSDQLYASCADFKIRTYSIN----QFSQLEILYGHHDIVEDISALAMERCVTVGARDRTA 224 Query: 167 ALWDIET--------GQQTTTF----------TGHTGDVM----------------SLSL 192 LW I G + G G+V + Sbjct: 225 MLWKIPDETRLTFRGGDEPQKLLRRWMKENAKEGEDGEVKYPDESEAPLFFCEGSIDVVS 284 Query: 193 APDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRL 252 D F++G+ + + LW + + T + F +G D R Sbjct: 285 MVDDFHFITGSDNGNICLWSLAKKKPIFTERIAHGILPEPSFND-----ISGETDEELRK 339 Query: 253 FDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDAL----KADRAGVL 308 L+ + L + ITS+ + ++G + VW + G L Sbjct: 340 RQLQGKKLLQPF-------WITSLYAIPYSNVFISGSWSGSLKVWKISDNLRSFELLGEL 392 Query: 309 AGHDNRVSCLGVTDDGMA 326 +G V+ + V + G Sbjct: 393 SGAKGVVTKIQVVESGKH 410 Score = 80.9 bits (198), Expect = 8e-16, Method: Composition-based stats. Identities = 24/124 (19%), Positives = 44/124 (35%) Query: 217 MCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSV 276 T GH +I + P+G TG D ++ + + + + S+ Sbjct: 105 EYENTTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRRGEVLSL 164 Query: 277 SFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFL 336 +F K+ L A DF + + + +L GH + V + V G+ D Sbjct: 165 AFRKNSDQLYASCADFKIRTYSINQFSQLEILYGHHDIVEDISALAMERCVTVGARDRTA 224 Query: 337 KIWN 340 +W Sbjct: 225 MLWK 228 Score = 74.0 bits (180), Expect = 8e-14, Method: Composition-based stats. Identities = 25/145 (17%), Positives = 53/145 (36%), Gaps = 7/145 (4%) Query: 171 IETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTF--TGHESD 228 + T GH ++++++ +PD + V+G D +W + + Sbjct: 101 TSKHEYENTTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRRGE 160 Query: 229 INAICFFPNGNAFATGSDDATCRLFDLRADQELMT-YSHDNIICGITSVSFSKSGRLLLA 287 + ++ F N + D R + + +L Y H +I+ I++++ R + Sbjct: 161 VLSLAFRKNSDQLYASCADFKIRTYSINQFSQLEILYGHHDIVEDISALAM---ERCVTV 217 Query: 288 GYDDFNCNVWDALKADRAGVLAGHD 312 G D +W R G D Sbjct: 218 GARDRTAMLWKIPDETRL-TFRGGD 241 Score = 47.8 bits (112), Expect = 8e-06, Method: Composition-based stats. Identities = 14/85 (16%), Positives = 28/85 (32%), Gaps = 2/85 (2%) Query: 255 LRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNR 314 + + + + I +V+ S G+ ++ G D VW V+ D R Sbjct: 99 IPTSKHEYENTTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRR 158 Query: 315 --VSCLGVTDDGMAVATGSWDSFLK 337 V L + + D ++ Sbjct: 159 GEVLSLAFRKNSDQLYASCADFKIR 183 Score = 43.1 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 19/78 (24%), Positives = 28/78 (35%), Gaps = 2/78 (2%) Query: 263 TYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTD 322 T S D + FSK + L Y K + GH + + + + Sbjct: 67 TVSKDLQLTKYDITDFSKRPKKL--KYAKGGAKYIPTSKHEYENTTEGHYDEILTVAASP 124 Query: 323 DGMAVATGSWDSFLKIWN 340 DG V TG D L +W+ Sbjct: 125 DGKYVVTGGRDRKLIVWS 142 Score = 34.7 bits (78), Expect = 0.065, Method: Composition-based stats. Identities = 17/106 (16%), Positives = 35/106 (33%), Gaps = 9/106 (8%) Query: 14 LKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLA----KIYAMHWGTDSRL 69 K + + N+I ++R +R L+G I +++ S + Sbjct: 306 AKKKPIFTERIAHGILPEPSFNDISGETDEELR-KRQLQGKKLLQPFWITSLYAIPYSNV 364 Query: 70 LVSASQDGKLIIW----DSYTTNKVHAIPLRSSWVMTCAYAPSGNY 111 +S S G L +W + + + + V SG + Sbjct: 365 FISGSWSGSLKVWKISDNLRSFELLGELSGAKGVVTKIQVVESGKH 410 >5WLC-SG nrPDB Length = 573 Score = 100 bits (250), Expect = 8e-22, Method: Composition-based stats. Identities = 55/318 (17%), Positives = 103/318 (32%), Gaps = 57/318 (17%) Query: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRS--SWVMTCAYAP 107 T GH +I + D + +V+ +D KLI+W + + + V IP + V++ A+ Sbjct: 231 TTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRRGEVLSLAFRK 290 Query: 108 SGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLD-DNQIVTSSGDTTC 166 + + + D Y++ L GH + L + + + D T Sbjct: 291 NSDQLYASCADFKIRTYSIN----QFSQLEILYGHHDIVEDISALAMERCVTVGARDRTA 346 Query: 167 ALWDIET--------GQQTTTF----------TGHTGDVM----------------SLSL 192 LW I G + G G+V + Sbjct: 347 MLWKIPDETRLTFRGGDEPQKLLRRWMKENAKEGEDGEVKYPDESEAPLFFCEGSIDVVS 406 Query: 193 APDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRL 252 D F++G+ + + LW + + T + F +G D R Sbjct: 407 MVDDFHFITGSDNGNICLWSLAKKKPIFTERIAHGILPEPSFND-----ISGETDEELRK 461 Query: 253 FDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDAL----KADRAGVL 308 L+ + L + ITS+ + ++G + VW + G L Sbjct: 462 RQLQGKKLLQPF-------WITSLYAIPYSNVFISGSWSGSLKVWKISDNLRSFELLGEL 514 Query: 309 AGHDNRVSCLGVTDDGMA 326 +G V+ + V + G Sbjct: 515 SGAKGVVTKIQVVESGKH 532 Score = 80.5 bits (197), Expect = 8e-16, Method: Composition-based stats. Identities = 24/124 (19%), Positives = 44/124 (35%) Query: 217 MCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSV 276 T GH +I + P+G TG D ++ + + + + S+ Sbjct: 227 EYENTTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRRGEVLSL 286 Query: 277 SFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFL 336 +F K+ L A DF + + + +L GH + V + V G+ D Sbjct: 287 AFRKNSDQLYASCADFKIRTYSINQFSQLEILYGHHDIVEDISALAMERCVTVGARDRTA 346 Query: 337 KIWN 340 +W Sbjct: 347 MLWK 350 Score = 74.0 bits (180), Expect = 9e-14, Method: Composition-based stats. Identities = 25/145 (17%), Positives = 53/145 (36%), Gaps = 7/145 (4%) Query: 171 IETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTF--TGHESD 228 + T GH ++++++ +PD + V+G D +W + + Sbjct: 223 TSKHEYENTTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRRGE 282 Query: 229 INAICFFPNGNAFATGSDDATCRLFDLRADQELMT-YSHDNIICGITSVSFSKSGRLLLA 287 + ++ F N + D R + + +L Y H +I+ I++++ R + Sbjct: 283 VLSLAFRKNSDQLYASCADFKIRTYSINQFSQLEILYGHHDIVEDISALAM---ERCVTV 339 Query: 288 GYDDFNCNVWDALKADRAGVLAGHD 312 G D +W R G D Sbjct: 340 GARDRTAMLWKIPDETRL-TFRGGD 363 Score = 47.4 bits (111), Expect = 8e-06, Method: Composition-based stats. Identities = 14/85 (16%), Positives = 28/85 (32%), Gaps = 2/85 (2%) Query: 255 LRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNR 314 + + + + I +V+ S G+ ++ G D VW V+ D R Sbjct: 221 IPTSKHEYENTTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRR 280 Query: 315 --VSCLGVTDDGMAVATGSWDSFLK 337 V L + + D ++ Sbjct: 281 GEVLSLAFRKNSDQLYASCADFKIR 305 Score = 43.1 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 19/78 (24%), Positives = 28/78 (35%), Gaps = 2/78 (2%) Query: 263 TYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTD 322 T S D + FSK + L Y K + GH + + + + Sbjct: 189 TVSKDLQLTKYDITDFSKRPKKL--KYAKGGAKYIPTSKHEYENTTEGHYDEILTVAASP 246 Query: 323 DGMAVATGSWDSFLKIWN 340 DG V TG D L +W+ Sbjct: 247 DGKYVVTGGRDRKLIVWS 264 Score = 34.7 bits (78), Expect = 0.065, Method: Composition-based stats. Identities = 17/106 (16%), Positives = 35/106 (33%), Gaps = 9/106 (8%) Query: 14 LKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLA----KIYAMHWGTDSRL 69 K + + N+I ++R +R L+G I +++ S + Sbjct: 428 AKKKPIFTERIAHGILPEPSFNDISGETDEELR-KRQLQGKKLLQPFWITSLYAIPYSNV 486 Query: 70 LVSASQDGKLIIW----DSYTTNKVHAIPLRSSWVMTCAYAPSGNY 111 +S S G L +W + + + + V SG + Sbjct: 487 FISGSWSGSLKVWKISDNLRSFELLGELSGAKGVVTKIQVVESGKH 532 >5OV3-A nrPDB Length = 381 Score = 100 bits (248), Expect = 1e-21, Method: Composition-based stats. Identities = 44/295 (14%), Positives = 97/295 (32%), Gaps = 31/295 (10%) Query: 67 SRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNL 126 LL DG+++IWD T I V + ++ G+ + DNI S +++ Sbjct: 37 GTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDV 96 Query: 127 KTREGNVRVSRELAGHTGYLSCCRFLD--DNQIVTSSGDTTCALWDIETGQQTTTFTGHT 184 + + + R + ++ N+++ + + + + Sbjct: 97 LSGDCDQRFRFP-----SPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDD 151 Query: 185 GDVMSLS-LAPDTRLFVSGACDASAKLWDVREGMCRQTF-----TGHESDINAICFFPNG 238 D+ ++ +G + +F T + + I +I F G Sbjct: 152 SDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKG 211 Query: 239 NAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVS------------FSKSGRLLL 286 + F + D R++D +E++T D + + FS G ++ Sbjct: 212 SCFLINTADRIIRVYD---GREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIV 268 Query: 287 AGYD-DFNCNVWDALKADRAGVLAGHDNR-VSCLGVTDDGMAVATGSWDSFLKIW 339 AG +W+ + +L G + + +A+ S + IW Sbjct: 269 AGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISS-GVVSIW 322 Score = 92.4 bits (228), Expect = 3e-19, Method: Composition-based stats. Identities = 35/204 (17%), Positives = 64/204 (31%), Gaps = 8/204 (3%) Query: 143 TGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSG 202 + L+C + D +WD T + H V SL + D VS Sbjct: 26 SMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSA 85 Query: 203 ACDASAKLWDVREGMCRQTFTGHESDINAICFFP-NGNAFATGSDDATCRLFDLRADQEL 261 + D WDV G C Q F S I + + P + N + + L + + Sbjct: 86 STDNIVSQWDVLSGDCDQRFR-FPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHV 144 Query: 262 MTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVL-----AGHDNRVS 316 + D+ + + SF + G + G V D + + Sbjct: 145 VLPVDDDSDLNVVA-SFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIK 203 Query: 317 CLGVTDDGMAVATGSWDSFLKIWN 340 + G + D +++++ Sbjct: 204 SIEFARKGSCFLINTADRIIRVYD 227 Score = 86.3 bits (212), Expect = 2e-17, Method: Composition-based stats. Identities = 38/278 (13%), Positives = 83/278 (29%), Gaps = 27/278 (9%) Query: 40 VGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSW 99 + + + H+ + ++ W D LVSAS D + WD + + S Sbjct: 52 WDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFR-FPSP 110 Query: 100 VMTCAYAPS--GNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQI 157 ++ Y P + C + T + V + + F + Sbjct: 111 ILKVQYHPRDQNKVLVCPMKSAPVML----TLSDSKHVVLPVDDDSDLNVVASFDRRGEY 166 Query: 158 V-TSSGDTTCALWDIETGQQTTTFTGHTGD-----VMSLSLAPDTRLFVSGACDASAKLW 211 + T + + ++ +F TG + S+ A F+ D +++ Sbjct: 167 IYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVY 226 Query: 212 DVR---------EGMCRQTFTG--HESDINAICFFPNGNAFATGS-DDATCRLFDLRADQ 259 D R E Q + + CF +G GS +++ Sbjct: 227 DGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGN 286 Query: 260 ELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVW 297 + H + V++ ++ + ++W Sbjct: 287 LVKIL-HGTRGELLLDVAWHPVRPIIASISS-GVVSIW 322 >5BJS-A nrPDB Length = 605 Score = 100 bits (248), Expect = 1e-21, Method: Composition-based stats. Identities = 36/174 (20%), Positives = 63/174 (36%), Gaps = 21/174 (12%) Query: 185 GDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFP-NGNAFAT 243 S D L + + K+++V EG +T GH IN + P N A+ Sbjct: 137 ASCWSKDPITDQPLLCIAGNEGNVKVYNVTEGKLYRTLVGHGGGINDLATSPANPYIIAS 196 Query: 244 GSDDATCRLFDLRADQ----ELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDA 299 SDD T R++ L + + + + SV+F +GR +L+ D N+W Sbjct: 197 ASDDTTIRIWSLAPEHEKQPCVCILGGEGHSYDLLSVAFHDNGRYVLSAGHDQVINLWAL 256 Query: 300 LKADRA-------------GVLAGHDNRVSCLGVTDDGMAVAT-GSWDSFLKIW 339 + H+N V C+ G + + + + +W Sbjct: 257 PEFPNEHMEIPIVIYYPHFSSSEIHNNLVDCVAF--YGDLILSRACHEDTIVLW 308 Score = 82.4 bits (202), Expect = 3e-16, Method: Composition-based stats. Identities = 30/154 (19%), Positives = 53/154 (34%), Gaps = 16/154 (10%) Query: 35 NNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRL-LVSASQDGKLIIWDSYTTN----- 88 N+ + + RTL GH I + + + SAS D + IW + Sbjct: 158 GNVKVYNVTEGKLYRTLVGHGGGINDLATSPANPYIIASASDDTTIRIWSLAPEHEKQPC 217 Query: 89 -KVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSREL-------- 139 + S +++ A+ +G YV G D + +++ L + Sbjct: 218 VCILGGEGHSYDLLSVAFHDNGRYVLSAGHDQVINLWALPEFPNEHMEIPIVIYYPHFSS 277 Query: 140 -AGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIE 172 H + C F D + + + T LW IE Sbjct: 278 SEIHNNLVDCVAFYGDLILSRACHEDTIVLWRIE 311 Score = 57.0 bits (136), Expect = 1e-08, Method: Composition-based stats. Identities = 14/77 (18%), Positives = 31/77 (40%), Gaps = 1/77 (1%) Query: 265 SHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTD-D 323 ++ S LL ++ N V++ + L GH ++ L + + Sbjct: 131 GNEANCASCWSKDPITDQPLLCIAGNEGNVKVYNVTEGKLYRTLVGHGGGINDLATSPAN 190 Query: 324 GMAVATGSWDSFLKIWN 340 +A+ S D+ ++IW+ Sbjct: 191 PYIIASASDDTTIRIWS 207 >3F3P-A nrPDB Length = 351 Score = 97.8 bits (242), Expect = 5e-21, Method: Composition-based stats. Identities = 49/329 (14%), Positives = 100/329 (30%), Gaps = 42/329 (12%) Query: 52 RGHLAKIYAMHWGTDSRLLVSASQDGKLIIW----DSYTTNKVHAIPLRSSWVMTCAYA- 106 GH ++ + + R + + S D + ++ D+ + S ++ +A Sbjct: 8 SGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWAS 67 Query: 107 -PSGNYVACGGLDNICSIYNLKTREGNVRVSR-----ELAGHTGYLSCCRFLDDN---QI 157 G +A D ++ + R L G L +F + ++ Sbjct: 68 PEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKL 127 Query: 158 VTSSGDTTCALWDIETGQQTTTFT-------------GHTGDVMSLSLAPD---TRLFVS 201 D L+D ++T H LS P Sbjct: 128 ACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAV 187 Query: 202 GACDASAKLWDVREGM--CRQTFTGHESDINAICFFPN----GNAFATGSDDATCRLFDL 255 A + + ++G GH+S I +I + P+ ATG D R+F + Sbjct: 188 SALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKI 247 Query: 256 RADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFN----CNVWDALKADRAGVLAGH 311 +L + + + S + G D N + L+ + H Sbjct: 248 TE--KLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDH 305 Query: 312 DNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 + V + G +++ D +++W Sbjct: 306 NGEVWSVSWNLTGTILSSAGDDGKVRLWK 334 Score = 86.7 bits (213), Expect = 1e-17, Method: Composition-based stats. Identities = 57/282 (20%), Positives = 110/282 (39%), Gaps = 34/282 (12%) Query: 52 RGHLAKIYAMHWGTD--SRLLVSASQDGKLIIWDSYT---------TNKVHAIPLRSSWV 100 R H + I A+ W + R++ SAS D + +W+ NK+ + + Sbjct: 54 RAHDSSIVAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSL 113 Query: 101 MTCAYAPS--GNYVACGGLDNICSIYNLK--------TREGNVRVSRELAG-HTGYLSCC 149 + +AP+ G +AC G D I +Y+ T ++V H C Sbjct: 114 YSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCL 173 Query: 150 RFLDDN----QIVTSSGDTTCALWDIETGQQT--TTFTGHTGDVMSLSLAP----DTRLF 199 + ++ S+ + + G+ GH + S+S AP +L Sbjct: 174 SWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLI 233 Query: 200 VSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATG-SDDATCRLFDLRAD 258 +G D +++ + E + ++ N + + A G SD T +L+++ Sbjct: 234 ATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSN 293 Query: 259 QELMTYS-HDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDA 299 ++ S HD+ + SVS++ +G +L + DD +W A Sbjct: 294 LQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKA 335 Score = 42.0 bits (97), Expect = 4e-04, Method: Composition-based stats. Identities = 16/86 (18%), Positives = 35/86 (40%), Gaps = 3/86 (3%) Query: 9 QEAEQLKNQIRDARKACADA---TLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGT 65 +E+ N ++ DA + S + +Q+ H +++++ W Sbjct: 257 EESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNL 316 Query: 66 DSRLLVSASQDGKLIIWDSYTTNKVH 91 +L SA DGK+ +W + +N+ Sbjct: 317 TGTILSSAGDDGKVRLWKATYSNEFK 342 >4PSX-B nrPDB Length = 401 Score = 97.5 bits (241), Expect = 8e-21, Method: Composition-based stats. Identities = 36/242 (14%), Positives = 80/242 (33%), Gaps = 30/242 (12%) Query: 47 TRRTLRGHLAKIYAMHWGT-DSRLLVSASQDGKLIIWDSYTT----NKVHAI-PLRSSWV 100 + TL+ H YA+ + T L+S S D + +W+ + V L S + Sbjct: 152 LQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDII 211 Query: 101 MTCAYAP-SGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFL--DDNQI 157 + + + D++ I +++ + + + F N + Sbjct: 212 NDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQ----PFNTLAFSHHSSNLL 267 Query: 158 VTSSGDTTCALWDIET-GQQTTTFTGHTGDVMSLSLAPD-TRLFVSGACDASAKLWDVRE 215 + D+ L+D+ + +GH V +L + + VS D +WD+++ Sbjct: 268 AAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQ 327 Query: 216 --------------GMCRQTFTGHESDINAICFFPNGNAF-ATGSDDATCRLFDLRADQE 260 GH S +N P A+ ++ +++ Sbjct: 328 IGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCSHSLP 387 Query: 261 LM 262 ++ Sbjct: 388 IV 389 Score = 92.4 bits (228), Expect = 2e-19, Method: Composition-based stats. Identities = 50/282 (17%), Positives = 97/282 (34%), Gaps = 32/282 (11%) Query: 85 YTTNKVHAIPLRSSWVMTCAYAP-SGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHT 143 + ++ A + Y P N VA +Y+ + L H Sbjct: 106 RSNIRITAKYEHEEEITRARYMPQDPNIVATINGQGTTFLYSRSEG-----LQSTLKFHK 160 Query: 144 GYLSCCRFLD--DNQIVTSSGDTTCALWDIETG----QQTTTFTG-HTGDVMSLSLAP-D 195 F ++++ S D T ALW++ +G + T+ H+ + + Sbjct: 161 DNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFN 220 Query: 196 TRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPN-GNAFATGSDDATCRLFD 254 LF + + D+ K+ DVR N + F + N A D+ L+D Sbjct: 221 KDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYD 280 Query: 255 LRADQELMTYSHDNIICGITSVSFSKS-GRLLLAGYDDFNCNVWDALK------------ 301 LR +E + + ++ FS ++++ D +WD + Sbjct: 281 LRNMKE-PLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAED 339 Query: 302 --ADRAGVLAGHDNRVSCLGVTDDGMA-VATGSWDSFLKIWN 340 + V AGH + V+ + VA+ ++ L++W Sbjct: 340 GVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWK 381 >6F1U-h nrPDB Length = 612 Score = 95.9 bits (237), Expect = 2e-20, Method: Composition-based stats. Identities = 51/318 (16%), Positives = 96/318 (30%), Gaps = 76/318 (23%) Query: 58 IYAMHWGTDSRLLVSASQ----------DGKLIIWDSYTTNKVHAIPLR-SSWVMTCAYA 106 + + W + L+ AS DG ++W+ S VM+ +A Sbjct: 256 VSCLDWSSQYPELLVASYNNNEDAPHEPDGVALVWNMKYKKTTPEYVFHCQSAVMSATFA 315 Query: 107 P-SGNYVACGGLDNICSIYNLKT--REGNVRVSRELAGHTGYLSCCRFL---DDNQIVTS 160 N V G +++ ++ R R A HT + C + + + +++ Sbjct: 316 KFHPNLVVGGTYSGQIVLWDNRSNKRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNLISI 375 Query: 161 SGDTTCALW--------------------------------DIETGQQTTT--------- 179 S D W D+ + Sbjct: 376 STDGKICSWSLDMLSHPQDSMELVHKQSKAVAVTSMSFPVGDVNNFVVGSEEGSVYTACR 435 Query: 180 ----------FTGHTGDVMSLSLA------PDTRLFVSGACDASAKLWDVREGMCRQTFT 223 F GH G + + + LFV+ + D + KLW + +F Sbjct: 436 HGSKAGISEMFEGHQGPITGIHCHAAVGAVDFSHLFVTSSFDWTVKLWSTKNNKPLYSFE 495 Query: 224 GHESDINAICFFPN-GNAFATGSDDATCRLFDLRADQELMTYS-HDNIICGITSVSFSKS 281 + + + + P FA L++L D E+ T S + V ++ S Sbjct: 496 DNAGYVYDVMWSPTHPALFACVDGMGRLDLWNLNNDTEVPTASISVEGNPALNRVRWTHS 555 Query: 282 GRLLLAGYDDFNCNVWDA 299 GR + G + ++D Sbjct: 556 GREIAVGDSEGQIVIYDV 573 Score = 90.9 bits (224), Expect = 7e-19, Method: Composition-based stats. Identities = 45/248 (18%), Positives = 86/248 (34%), Gaps = 34/248 (13%) Query: 34 TNNIDPVGRIQMRTRRTLRGHLAKIYAMHW--GTDSRLLVSASQDGKLIIWDSYTTNKVH 91 +N PV R + H +Y ++ ++ L+S S DGK+ W + Sbjct: 338 SNKRTPVQRTPLSA----AAHTHPVYCVNVVGTQNAHNLISISTDGKICSWSLDMLSHPQ 393 Query: 92 A------IPLRSSWVMTCAYAPSGNY--VACGGLDNICSIYNLKTREGNVRVSRELAGHT 143 ++ V + ++ P G+ G + S+Y +S GH Sbjct: 394 DSMELVHKQSKAVAVTSMSF-PVGDVNNFVVGSEEG--SVYTACRHGSKAGISEMFEGHQ 450 Query: 144 GYLS---------CCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAP 194 G ++ F + VTSS D T LW + + +F + G V + +P Sbjct: 451 GPITGIHCHAAVGAVDFS--HLFVTSSFDWTVKLWSTKNNKPLYSFEDNAGYVYDVMWSP 508 Query: 195 DTRLFVSGACDASAK--LWDVREGMCRQTFTGH---ESDINAICFFPNGNAFATGSDDAT 249 + D + LW++ T + +N + + +G A G + Sbjct: 509 THPALFAC-VDGMGRLDLWNLNNDTEVPTASISVEGNPALNRVRWTHSGREIAVGDSEGQ 567 Query: 250 CRLFDLRA 257 ++D+ Sbjct: 568 IVIYDVGE 575 >5A9Q-7 nrPDB Length = 360 Score = 94.8 bits (234), Expect = 4e-20, Method: Composition-based stats. Identities = 55/328 (16%), Positives = 112/328 (34%), Gaps = 58/328 (17%) Query: 48 RRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWD---SYTTNKVHAIPLRSSWVMTCA 104 R H I+ + + R + + S D + +WD S + + S V Sbjct: 5 RSIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVT 64 Query: 105 YAPS--GNYVACGGLDNICSIYNLKTREGNVRVSR--------ELAGHTGYLSCCRFLDD 154 +A G +A D +++ E N ++ L ++ +F Sbjct: 65 WAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPK 124 Query: 155 N---QIVTSSGDTTCALW---DIETGQQTTTFTGHT--GDVMSLSLAP-----DTRLFVS 201 + + T S D ++ D+ Q + + +S P + + Sbjct: 125 HMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSPMIAV 184 Query: 202 GACDA------SAKLWDVREGMCR----QTFTGHESDINAICFFPNG----NAFATGSDD 247 G+ D+ ++++ E + +T ++ I F PN + A + D Sbjct: 185 GSDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAIATKD 244 Query: 248 ATCRLFDLRADQELMTYS-------------HDNIICGITSVSFSKSGRLLLAGYDDFNC 294 R+F L+ ++ +T S DN + VS++ +G +L + DD Sbjct: 245 --VRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCV 302 Query: 295 NVWDAL---KADRAGVLAGHDNRVSCLG 319 +W A G+L G+ + V+ Sbjct: 303 RLWKANYMDNWKCTGILKGNGSPVNGSS 330 Score = 91.7 bits (226), Expect = 4e-19, Method: Composition-based stats. Identities = 38/297 (12%), Positives = 97/297 (32%), Gaps = 53/297 (17%) Query: 96 RSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLD-- 153 + ++ G +A D +++ K+ G+ + H+G + + Sbjct: 11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWD-KSESGDWHCTASWKTHSGSVWRVTWAHPE 69 Query: 154 -DNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDV------------MSLSLAPD--TRL 198 + + S D T A+W+ G+ G + V + AP + Sbjct: 70 FGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLM 129 Query: 199 FVSGACDASAKLWDVREGMCRQTFT-GHESDIN----AICFFPNGN-----AFATGSDDA 248 + + D ++++ + M ++ HE I + P+ + A GSDD+ Sbjct: 130 LATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSPMIAVGSDDS 189 Query: 249 T------CRLFDLRADQELMTYSHD--NIICGITSVSFSKSG----RLLLAGYDDFNCNV 296 + ++F+ + + + + ++F+ + +L D Sbjct: 190 SPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAIATKDVRIFT 249 Query: 297 WDALKADR-------------AGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 ++ + H+++V + G +A+ D +++W Sbjct: 250 LKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWK 306 Score = 50.5 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 17/78 (21%), Positives = 27/78 (34%), Gaps = 5/78 (6%) Query: 268 NIICGITSVSFSKSGRLLLAGYDDFNCNVWDALK---ADRAGVLAGHDNRVSCLGV-TDD 323 + I VSF GR + D + VWD + H V + + Sbjct: 10 DHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPE 69 Query: 324 -GMAVATGSWDSFLKIWN 340 G +A+ S+D +W Sbjct: 70 FGQVLASCSFDRTAAVWE 87 Score = 40.1 bits (92), Expect = 0.001, Method: Composition-based stats. Identities = 9/64 (14%), Positives = 23/64 (35%), Gaps = 3/64 (4%) Query: 41 GRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYT---TNKVHAIPLRS 97 + ++ H ++++ + W +L S+ DG + +W + + Sbjct: 264 TKFEIHIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWKANYMDNWKCTGILKGNG 323 Query: 98 SWVM 101 S V Sbjct: 324 SPVN 327 >3EI3-B nrPDB Length = 383 Score = 94.4 bits (233), Expect = 6e-20, Method: Composition-based stats. Identities = 54/319 (16%), Positives = 107/319 (33%), Gaps = 27/319 (8%) Query: 46 RTRRTLRGHLAKIYAMHWGTDSRL-LVSASQDGKLIIWDSYTTNKVHAIPLRS--SWVMT 102 + RT ++ ++ W + S+ G +I+WD NK I + Sbjct: 64 KLHRTASPFDRRVTSLEWHPTHPTTVAVGSKGGDIILWDYDVQNKTSFIQGMGPGDAITG 123 Query: 103 CAYAP-SGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSS 161 + + N + + ++ + ++V + + C Q++ + Sbjct: 124 MKFNQFNTNQLFVSSIRGATTLRDFSG--SVIQVFAKTDSWDYWYCCVDVSVSRQMLATG 181 Query: 162 GDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTR-LFVSGACDASAKLWDVREGMCRQ 220 T L G + H V P L + + DA+ KLWD+R + Sbjct: 182 DSTGRLLLLGLDGHEIFKEKLHKAKVTHAEFNPRCDWLMATSSVDATVKLWDLRNIKDKN 241 Query: 221 TFTG---HESDINAICFFP-NGNAFATGSDDATCRL---FDLRADQELMTYSHDNIIC-G 272 ++ HE +NA F P + T R+ +D +++ + H Sbjct: 242 SYIAEMPHEKPVNAAYFNPTDSTKLLTTDQRNEIRVYSSYDWSKPDQIIIHPHRQFQHLT 301 Query: 273 ITSVSFSKSGRLLLAG---------YDDFNCNVWDALKADRAGVLAG-HDNRVSCL-GVT 321 ++ L++AG D +++DA L + + L + Sbjct: 302 PIKATWHPMYDLIVAGRYPDDQLLLNDKRTIDIYDANSGGLVHQLRDPNAAGIISLNKFS 361 Query: 322 DDGMAVATGSWDSFLKIWN 340 G +A+G + L IWN Sbjct: 362 PTGDVLASGMGFNIL-IWN 379 >6CHG-D nrPDB Length = 439 Score = 93.2 bits (230), Expect = 2e-19, Method: Composition-based stats. Identities = 54/347 (15%), Positives = 107/347 (30%), Gaps = 49/347 (14%) Query: 38 DPVG---RIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIP 94 DP G + TL +A + + + L +G +II+D + + + Sbjct: 8 DPFGVLKEYPEKLTHTLEVPVAAV-CVKFSPRGDYLAVGCSNGAIIIYDMDSLKPIAMLG 66 Query: 95 LRSSW----VMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCR 150 S V + ++ G Y+ G D ++++ + + G R Sbjct: 67 THSGAHTRSVQSVCWSNDGRYLWSSGRDWYAKLWDMTQPTKCFQQYK-FDGPLWSCHVVR 125 Query: 151 FL--------DDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPD---TRLF 199 + + V + D A +Q +GH +L P + Sbjct: 126 WNVCIVTVVEEPTAYVLTLTDRQNAFHCFPLLEQDQDISGHG---YTLVACPHPTIESII 182 Query: 200 VSGACDASAKLW--DVREG-----MCRQTFTGHESDINAICFFPNGNAFATGSDDATCRL 252 ++G + D+ G C ++I I P+G A D T R Sbjct: 183 ITGTSKGWINAFQLDLESGFEDKIRCCYEEKIANANIKQIIISPSGTRIAINGSDRTIRQ 242 Query: 253 FDL---------RADQELMTYSHDNIICGITSVSFSK------SGRLLLA---GYDDFNC 294 + L + + I + ++ SG L+A G + Sbjct: 243 YQLIVEDNESEGGSSHSVSIELEHKYQDIINRLQWNTIFFSNHSGEYLVASAHGSSAHDL 302 Query: 295 NVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGS-WDSFLKIWN 340 +W+ VL G D + + M +A+ ++ +W+ Sbjct: 303 YLWETSSGSLVRVLEGADEELLDIDWNFYSMRIASNGFESGWVYMWS 349 >6BX3-B nrPDB Length = 412 Score = 93.2 bits (230), Expect = 2e-19, Method: Composition-based stats. Identities = 47/317 (14%), Positives = 101/317 (31%), Gaps = 42/317 (13%) Query: 60 AMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHA----IPLRSSWVMTCAYAPSGNYVACG 115 + + L +G L+I+D T + + + + A++P G + Sbjct: 30 CLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTS 89 Query: 116 GLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLD--------------DNQIVTSS 161 D +++L ++ R + C++LD D ++ S Sbjct: 90 SRDWSIKLWDLSKPSKPLKEIRF----DSPIWGCQWLDAKRRLCVATIFEESDAYVIDFS 145 Query: 162 GDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDA----SAKLWDVREGM 217 D +L +Q ++ H G V+ ++ + K + + Sbjct: 146 NDPVASLLSKSDEKQLSSTPDH-GYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTE 204 Query: 218 CRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELM----TYSHDNIICGI 273 C + S+I + NG A D T R +++ D E T H I Sbjct: 205 CIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHK-YQDVI 263 Query: 274 TSVSF------SKSGRLLLA---GYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDG 324 + + + + L+A G +W+ VL G + + + Sbjct: 264 NKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEEELIDINWDFYS 323 Query: 325 MAVATGS-WDSFLKIWN 340 M++ + + +W+ Sbjct: 324 MSIVSNGFESGNVYVWS 340 Score = 60.5 bits (145), Expect = 1e-09, Method: Composition-based stats. Identities = 19/90 (21%), Positives = 38/90 (42%), Gaps = 5/90 (5%) Query: 255 LRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRA----GVLAG 310 L+ E +T++ +N + + FS G L G + ++D +L Sbjct: 11 LKEHPEKLTHTIENPLRT-ECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGA 69 Query: 311 HDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 H ++ + + DG + T S D +K+W+ Sbjct: 70 HVRPITSIAWSPDGRLLLTSSRDWSIKLWD 99 >6E29-D nrPDB Length = 345 Score = 91.7 bits (226), Expect = 4e-19, Method: Composition-based stats. Identities = 43/217 (19%), Positives = 81/217 (37%), Gaps = 23/217 (10%) Query: 143 TGYLSCCRFLDDNQIVTSSG-DTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVS 201 +G+ +C RF + S D T +WD+ET GH+ ++ SLS + R +S Sbjct: 25 SGHSTCVRFNRKGDFLASGRVDGTVVIWDLETMGVARKLRGHSKNITSLSWSRCGRYLLS 84 Query: 202 GACDASAKLWDVREGMCRQTFTGHESDINAICFFP-NGNAFATGSDDATCRLFDLRADQE 260 LWD+++G + + + P N + FA + L D+ E Sbjct: 85 ACQGWKVILWDLQDGKRYREVR-FRAPVYGAELHPWNHHQFAAALFEDQPMLVDITEPVE 143 Query: 261 L--------------------MTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDAL 300 + + ++ T++ ++ SG LLAG N+ DA Sbjct: 144 VRYVLPSVPKRTSTETDPALREKQAKEDAKHMTTAIVYTASGDHLLAGTTKGRLNIIDAR 203 Query: 301 KADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLK 337 + ++ L +T+ G + + D ++ Sbjct: 204 TREIIYSEKIASGIITTLRLTESGRELLVNAQDRIIR 240 Score = 91.7 bits (226), Expect = 4e-19, Method: Composition-based stats. Identities = 47/322 (14%), Positives = 99/322 (30%), Gaps = 36/322 (11%) Query: 52 RGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNY 111 GH + + L S DG ++IWD T + S + + +++ G Y Sbjct: 25 SGHS---TCVRFNRKGDFLASGRVDGTVVIWDLETMGVARKLRGHSKNITSLSWSRCGRY 81 Query: 112 VACGGLDNICSIYNLKTRE--GNVRVSRELAG------HTGYLSCCRFLDDNQIVTSSGD 163 + +++L+ + VR + G + + F D +V + Sbjct: 82 LLSACQGWKVILWDLQDGKRYREVRFRAPVYGAELHPWNHHQFAAALFEDQPMLVDITEP 141 Query: 164 TTCALWDIETGQQTTTFTGHT-----------GDVMSLSLAPDTRLFVSGACDASAKLWD 212 ++T+T T ++ ++G + D Sbjct: 142 VEVRYVLPSVPKRTSTETDPALREKQAKEDAKHMTTAIVYTASGDHLLAGTTKGRLNIID 201 Query: 213 VREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLF--------DLRADQELMTY 264 R + I + +G + D R F DL D + Sbjct: 202 ARTREIIYSEKIASGIITTLRLTESGRELLVNAQDRIIRTFIVPNLSAADLDPDTIQLPL 261 Query: 265 SH--DNIICGITS--VSFSKSGRLLLAG-YDDFNCNVWDALKADRAGVLAGHDNRVSCLG 319 H +++ ++ V+FS +G + A Y++ +W+ +L G + Sbjct: 262 EHKFQDVVNRLSWNHVAFSATGEYVAASTYNNHELYIWERGHGSLVRMLEGPKEEQGVIE 321 Query: 320 VTDDGMAVATGSWD-SFLKIWN 340 +A + + IW+ Sbjct: 322 WHPHRALLAACGLETGRINIWS 343 Score = 37.0 bits (84), Expect = 0.013, Method: Composition-based stats. Identities = 12/52 (23%), Positives = 22/52 (42%), Gaps = 5/52 (9%) Query: 289 YDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 DD+ D + + +GH +C+ G +A+G D + IW+ Sbjct: 7 SDDYLLQ--DYPENITNTIRSGHS---TCVRFNRKGDFLASGRVDGTVVIWD 53 >5A9Q-2 nrPDB Length = 326 Score = 89.7 bits (221), Expect = 1e-18, Method: Composition-based stats. Identities = 49/192 (25%), Positives = 78/192 (40%), Gaps = 33/192 (17%) Query: 170 DIETGQQTTTFTGHTG-DVMSLSLAPDTRL--------FVSGACDASAKLW--DVREGMC 218 D+E Q T T H G V ++ +P+TRL F + A D +L+ D+++ Sbjct: 57 DVEGIQYKTLRTFHHGVRVDGIAWSPETRLDSLPPVIKFCTSAADMKIRLFTSDLQDKNE 116 Query: 219 RQTFTGHESDINAICFFP-NGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVS 277 + GH IN + F P G A+ SDD TCR+++L Q H SV Sbjct: 117 YKVLEGHTDFINGLVFDPKEGQEIASVSDDHTCRIWNLEGVQTAHFVLH----SPGMSVC 172 Query: 278 FSKSGRL-LLAGYDDFNCNVWDA--------LKADRAGVLAGHDNRVSCLGVTDDGMAVA 328 + L+ + +D L++++ +++ H CL T AVA Sbjct: 173 WHPEETFKLMVAEKNGTIRFYDLLAQQAILSLESEQVPLMSAH----WCLKNTFKVGAVA 228 Query: 329 TGSWDSFLKIWN 340 W IW+ Sbjct: 229 GNDW----LIWD 236 Score = 77.4 bits (189), Expect = 9e-15, Method: Composition-based stats. Identities = 40/259 (15%), Positives = 80/259 (30%), Gaps = 20/259 (7%) Query: 95 LRSSWVMTCAYAPSGNY--------VACGGLDNICSIYNLKTREGNVRVSRELAGHTGYL 146 V A++P D ++ ++ N + L GHT ++ Sbjct: 70 HHGVRVDGIAWSPETRLDSLPPVIKFCTSAADMKIRLFTSDLQDKNE--YKVLEGHTDFI 127 Query: 147 SCCRFLD--DNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRL-FVSGA 203 + F +I + S D TC +W++E G QT F H+ MS+ P+ + Sbjct: 128 NGLVFDPKEGQEIASVSDDHTCRIWNLE-GVQTAHFVLHSPG-MSVCWHPEETFKLMVAE 185 Query: 204 CDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQ--EL 261 + + + +D+ + + + + + ++D+ + Sbjct: 186 KNGTIRFYDLLAQQAILSLESEQVPLMSAHWCLKNTFKVGAVAGNDWLIWDITRSSYPQN 245 Query: 262 MTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALK-ADRAGVLAGHDNRVSCLGV 320 H + C + S++ GY + + +L G S L Sbjct: 246 KRPVHMDRACLFRWSTISEN-LFATTGYPGKMASQFQIHHLGHPQPILMGSVAVGSGLSW 304 Query: 321 TDDGMAVATGSWDSFLKIW 339 G D L W Sbjct: 305 HRTLPLCVIGG-DHKLLFW 322 Score = 68.9 bits (167), Expect = 3e-12, Method: Composition-based stats. Identities = 27/213 (12%), Positives = 57/213 (26%), Gaps = 14/213 (6%) Query: 48 RRTLRGHLAKIYAMHWGT-DSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYA 106 + L GH I + + + + + S S D IW+ H + M+ + Sbjct: 117 YKVLEGHTDFINGLVFDPKEGQEIASVSDDHTCRIWNLEGVQTAHFVLHSPG--MSVCWH 174 Query: 107 PSGNY-VACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSS-GDT 164 P + + + Y+L ++ L L + N + Sbjct: 175 PEETFKLMVAEKNGTIRFYDLLAQQA----ILSLESEQVPLMSAHWCLKNTFKVGAVAGN 230 Query: 165 TCALWDI-ETGQQTTTFTGHTGDVMSLSLAP-DTRLFVSGAC-DASAKLWDVRE-GMCRQ 220 +WDI + H + LF + A + + G + Sbjct: 231 DWLIWDITRSSYPQNKRPVHMDRACLFRWSTISENLFATTGYPGKMASQFQIHHLGHPQP 290 Query: 221 TFTGHESDINAICFFPNGNAFATGSDDATCRLF 253 G + + + + D + Sbjct: 291 ILMGSVAVGSGLSWHRTLP-LCVIGGDHKLLFW 322 >3I2N-A nrPDB Length = 357 Score = 89.0 bits (219), Expect = 2e-18, Method: Composition-based stats. Identities = 49/338 (14%), Positives = 103/338 (30%), Gaps = 55/338 (16%) Query: 52 RGHLAKIYAMHWGTDSRLLVSASQ----DGKLIIWDSYTTN-KVHAIPLRSSWVMTCAYA 106 +G ++ W S V+ G + +++ + K+ ++ + + Sbjct: 15 KGFNYTVFDCKWVPCSAKFVTMGNFARGTGVIQLYEIQHGDLKLLREIEKAKPIKCGTFG 74 Query: 107 PSG---NYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDD-------NQ 156 + Y+A G I+NL+ E + GH ++ + + Sbjct: 75 ATSLQQRYLATGDFGGNLHIWNLEAPE---MPVYSVKGHKEIINAIDGIGGLGIGEGAPE 131 Query: 157 IVTSSGDTTCALWDIETG-QQTTTFT---GHTG-DVMSLSL----APDTRLFVSGACDAS 207 IVT S D T +WD G D +++ + R+ +G + Sbjct: 132 IVTGSRDGTVKVWDPRQKDDPVANMEPVQGENKRDCWTVAFGNAYNQEERVVCAGYDNGD 191 Query: 208 AKLWDVREGMCRQTFTGHESDINAICFFPNG---NAFATGSDDATCRLFDLRADQE---L 261 KL+D+R M + T ++ + ++ F N S + +FD+R Sbjct: 192 IKLFDLRN-MALRWETNIKNGVCSLEFDRKDISMNKLVATSLEGKFHVFDMRTQHPTKGF 250 Query: 262 MTYSHDNIICGITSVSFSK-SGRLLLAGYDDFNCNVWDAL-------------------K 301 + S + V + L L ++W Sbjct: 251 ASVSEKAHKSTVWQVRHLPQNRELFLTAGGAGGLHLWKYEYPIQRSKKDSEGIEMGVAGS 310 Query: 302 ADRAGVLAGHDNRVSCLGVTDDGMAVATGSW-DSFLKI 338 + +S L + D + S D +++ Sbjct: 311 VSLLQNVTLSTQPISSLDWSPDKRGLCVCSSFDQTVRV 348 Score = 50.1 bits (118), Expect = 1e-06, Method: Composition-based stats. Identities = 22/131 (16%), Positives = 43/131 (32%), Gaps = 13/131 (9%) Query: 223 TGHESDINAICFFPNGNAFAT----GSDDATCRLFDLRAD--QELMTYSHDNIICGITSV 276 G + + P F T +L++++ + L I T Sbjct: 15 KGFNYTVFDCKWVPCSAKFVTMGNFARGTGVIQLYEIQHGDLKLLREIEKAKPIKCGTFG 74 Query: 277 SFSKSGRLLLAGYDDFNCNVWDALKAD-RAGVLAGHDNRVSCLGVTDDGMA------VAT 329 + S R L G N ++W+ + + GH ++ + + T Sbjct: 75 ATSLQQRYLATGDFGGNLHIWNLEAPEMPVYSVKGHKEIINAIDGIGGLGIGEGAPEIVT 134 Query: 330 GSWDSFLKIWN 340 GS D +K+W+ Sbjct: 135 GSRDGTVKVWD 145 >3JZG-A nrPDB Length = 402 Score = 86.3 bits (212), Expect = 2e-17, Method: Composition-based stats. Identities = 46/306 (15%), Positives = 95/306 (31%), Gaps = 43/306 (14%) Query: 59 YAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAP-SGNYVACGGL 117 + T LL A G + I + T + + + + P N + Sbjct: 113 WTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSK 172 Query: 118 DNICSIYNLKTREGNVRVSRELAGHTGYLSCCRF-LDDNQIVTSSGDTTCALWDIETGQQ 176 D+ ++N++T + V + + GH + + L +I++ D + LW I + + Sbjct: 173 DHALRLWNIQT-DTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRM 231 Query: 177 TTTFTGHTGDVMSLSLAPD--TRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICF 234 S P+ R F+S D H + ++ + + Sbjct: 232 MNAIK------ESYDYNPNKTNRPFIS----QKIHFPDFSTRDI------HRNYVDCVRW 275 Query: 235 FPNGNAFATGSDDATCRLF----------DLRADQELMTY--SHDNIICGITSVSFSKS- 281 G+ + S + + ++ + +T D C I + FS Sbjct: 276 L--GDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDF 333 Query: 282 -GRLLLAGYDDFNCNVWDA----LKADRAGVLAGHD--NRVSCLGVTDDGMAVATGSWDS 334 ++L G VWD + L H + + D + D+ Sbjct: 334 WQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDA 393 Query: 335 FLKIWN 340 + W+ Sbjct: 394 SIWRWD 399 Score = 61.6 bits (148), Expect = 5e-10, Method: Composition-based stats. Identities = 38/225 (16%), Positives = 72/225 (32%), Gaps = 41/225 (18%) Query: 52 RGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNY 111 GH ++ + + ++S D L +W + ++AI + Y P+ Sbjct: 194 EGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKE------SYDYNPNKTN 247 Query: 112 VACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALW-- 169 + TR+ H Y+ C R+L + I++ S + W Sbjct: 248 RPFISQ--KIHFPDFSTRDI----------HRNYVDCVRWL-GDLILSKSCENAIVCWKP 294 Query: 170 -----DIETGQQTT---TFTGHTG------DVMSLSLAPDTRLFVSGACDASAKLWDVR- 214 DI+ + + T G M S+ ++ G +WD+ Sbjct: 295 GKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEV 354 Query: 215 ---EGMCRQTFTGHE--SDINAICFFPNGNAFATGSDDATCRLFD 254 T T H+ + I F + + DDA+ +D Sbjct: 355 EDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWD 399 Score = 52.0 bits (123), Expect = 4e-07, Method: Composition-based stats. Identities = 20/139 (14%), Positives = 42/139 (30%), Gaps = 13/139 (9%) Query: 215 EGMCRQTF-TGHESDINAICF---FPNGNAFATGS-DDATCRLFDLRADQELMTY----- 264 C + H + + F G+ + L++ + E+ Sbjct: 42 SFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVD 101 Query: 265 --SHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTD 322 + +N + + S LL + + + GH N ++ L Sbjct: 102 ADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHP 161 Query: 323 -DGMAVATGSWDSFLKIWN 340 D + + S D L++WN Sbjct: 162 RDPNLLLSVSKDHALRLWN 180 >5A9Q-0 nrPDB Length = 380 Score = 85.9 bits (211), Expect = 2e-17, Method: Composition-based stats. Identities = 49/283 (17%), Positives = 93/283 (32%), Gaps = 41/283 (14%) Query: 97 SSWVMTCAYAP-------SGNYVACGGLDNI---CSIYNLK---------TREGNVRVSR 137 S + + P + A G DN S++++ EG+ ++ Sbjct: 10 SQKISKTRWRPLPPGSLQTAETFATGSWDNEENYISLWSIGDFGNLDSDGGFEGDHQLLC 69 Query: 138 ELAGHTGYLSCCRFLDDNQIVTSSGDT--TCALWDIET-----GQQTTTFTGHTGDVM-- 188 ++ H G + +F D +IV +S T L QQ TT HTG Sbjct: 70 DIRHH-GDVMDLQFFDQERIVAASSTGCVTVFLHHPNNQTLSVNQQWTTAHYHTGPGSPS 128 Query: 189 -----SLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFT-GHESDINAICFFPNGNAFA 242 + + V+ D L+ +T S ++A+ F Sbjct: 129 YSSAPCTGVVCNNPEIVTVGEDGRINLFRADHKEAVRTIDNADSSTLHAVTFLRTPEILT 188 Query: 243 TGSDDATCRLFDLRA--DQELMTYSHDNIICGITSVSFSKSGRLLLA-GYDDFNCNVWDA 299 S +++D R ++ S + V + + ++A G D ++WD Sbjct: 189 VNSI-GQLKIWDFRQQGNEPSQILSLTGDRVPLHCVDRHPNQQHVVATGGQDGMLSIWDV 247 Query: 300 LKAD-RAGVLAGHDNRVSCLGVTD-DGMAVATGSWDSFLKIWN 340 + +L H+ + + + + T S D L W+ Sbjct: 248 RQGTMPVSLLKAHEAEMWEVHFHPSNPEHLFTCSEDGSLWHWD 290 Score = 77.4 bits (189), Expect = 7e-15, Method: Composition-based stats. Identities = 24/166 (14%), Positives = 55/166 (33%), Gaps = 4/166 (2%) Query: 66 DSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYN 125 ++ +V+ +DG++ ++ + V I S + + I++ Sbjct: 140 NNPEIVTVGEDGRINLFRADHKEAVRTIDNADSSTLHAVTFLRTPEILTVNSIGQLKIWD 199 Query: 126 LKTREGNVRVSRELAGHTGYLSCCRFLDDNQ--IVTSSGDTTCALWDIETGQ-QTTTFTG 182 + + L G L C + Q + T D ++WD+ G + Sbjct: 200 FRQQGNEPSQILSLTGDRVPLHCVDRHPNQQHVVATGGQDGMLSIWDVRQGTMPVSLLKA 259 Query: 183 HTGDVMSLSLAPDTR-LFVSGACDASAKLWDVREGMCRQTFTGHES 227 H ++ + P + + D S WD + ++ H+ Sbjct: 260 HEAEMWEVHFHPSNPEHLFTCSEDGSLWHWDASTDVPEKSSLFHQG 305 Score = 74.0 bits (180), Expect = 9e-14, Method: Composition-based stats. Identities = 48/279 (17%), Positives = 91/279 (32%), Gaps = 47/279 (16%) Query: 54 HLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVM----TCAYAPSG 109 H + + + D +V+AS G + ++ + N + + W T +PS Sbjct: 73 HHGDVMDLQFF-DQERIVAASSTGCVTVFLHHPNN--QTLSVNQQWTTAHYHTGPGSPSY 129 Query: 110 NYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALW 169 + C G+ +C+ + T + R++ A H + D + + + Sbjct: 130 SSAPCTGV--VCNNPEIVTVGEDGRINLFRADHKEAVRTIDNADSSTLHAVTF------- 180 Query: 170 DIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVR----EGMCRQTFTGH 225 + T + T V S+ K+WD R E + TG Sbjct: 181 -LRTPEILT--------VNSI---------------GQLKIWDFRQQGNEPSQILSLTGD 216 Query: 226 ESDINAICFFPNG-NAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRL 284 ++ + PN + ATG D ++D+R ++ + V F S Sbjct: 217 RVPLHCVDRHPNQQHVVATGGQDGMLSIWDVRQGTMPVSL-LKAHEAEMWEVHFHPSNPE 275 Query: 285 -LLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTD 322 L +D + WDA H S ++ Sbjct: 276 HLFTCSEDGSLWHWDASTDVPEKSSLFHQGGRSSTFLSH 314 Score = 40.4 bits (93), Expect = 0.001, Method: Composition-based stats. Identities = 13/59 (22%), Positives = 26/59 (44%), Gaps = 1/59 (1%) Query: 51 LRGHLAKIYAMHWGT-DSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPS 108 L+ H A+++ +H+ + L + S+DG L WD+ T + + + S Sbjct: 257 LKAHEAEMWEVHFHPSNPEHLFTCSEDGSLWHWDASTDVPEKSSLFHQGGRSSTFLSHS 315 >3JB9-S nrPDB Length = 488 Score = 85.1 bits (209), Expect = 4e-17, Method: Composition-based stats. Identities = 51/347 (14%), Positives = 121/347 (34%), Gaps = 33/347 (9%) Query: 2 SELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAM 61 S +++ QE + + + K D +SQ+ + T T + Sbjct: 164 STVEKTFQELSSKRKRTKLQPKWATDDAVSQLLQATPSTILENLETEST--------TSF 215 Query: 62 HWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNIC 121 ++ V +L+ D + + + + + C + + + +A D Sbjct: 216 FPSPENSSFVLCLHKDELLCLDIQSNSTLKIFEGSA---LACCWL-TSSKIAVATADA-I 270 Query: 122 SIYNLKTREGNVRVSRELAGH---TGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTT 178 SI+ ++ E ++ + + + ++ + C ++ +++ Sbjct: 271 SIFEFPVSSSGLQSVGEPTSSIPIDEKVNFLQAHPSGEYLLAASNEKCYIFSLKSQVYNI 330 Query: 179 TFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNG 238 T H + SL++ PD LFV+G + + ++ G F H S + + F NG Sbjct: 331 TVAQH---ITSLAVHPDGNLFVAGLENGELRFFETSSGNELTKFGPHSSPVKTLQFGENG 387 Query: 239 NAF-ATGSDDATCRLFDLRADQELMTYSHDNIICGI-----TSVSFSKSGRLLLAGYDDF 292 T +DD+ ++DLR + + + + + + S G L Sbjct: 388 YWLVVTTNDDSDIFIWDLRKSELVQKIPLQTKVAAVSLDITSQLLVSSDGETLYV----- 442 Query: 293 NCNVWDALKADRAGVLAGHDNRVSCLGVTDD-GMAVATGSWDSFLKI 338 + V + H + +S L ++ + + S + L++ Sbjct: 443 HIYVKSSKSWRCMSQT--HVSSISNLVWLNELHQLLFSTSNGAILRL 487 Score = 50.8 bits (120), Expect = 7e-07, Method: Composition-based stats. Identities = 30/162 (18%), Positives = 52/162 (32%), Gaps = 14/162 (8%) Query: 184 TGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFAT 243 T S +P+ FV D++ + F G A C+ + A Sbjct: 209 TESTTSFFPSPENSSFVLCLHKDELLCLDIQSNSTLKIFEG---SALACCWL-TSSKIAV 264 Query: 244 GSDDATCRLFDLRADQE-LMTYSHDNIICGI----TSVSFSKSGRLLLAGYDDFNCNVWD 298 + DA +F+ L + I + SG LLA ++ C ++ Sbjct: 265 ATADA-ISIFEFPVSSSGLQSVGEPTSSIPIDEKVNFLQAHPSGEYLLAASNE-KCYIFS 322 Query: 299 ALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 +A H ++ L V DG G + L+ + Sbjct: 323 LKSQVYNITVAQH---ITSLAVHPDGNLFVAGLENGELRFFE 361 >3DWL-C nrPDB Length = 377 Score = 83.6 bits (205), Expect = 1e-16, Method: Composition-based stats. Identities = 44/206 (21%), Positives = 75/206 (36%), Gaps = 24/206 (11%) Query: 157 IVTSSGDTTCALW--DIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVR 214 VT++ L+ D + TF+ H V + AP + V+ + D +A +++ R Sbjct: 26 FVTTTATNQVELYEQDGNGWKHARTFSDHDKIVTCVDWAPKSNRIVTCSQDRNAYVYEKR 85 Query: 215 -EGMCRQTFT--GHESDINAICFFPNGNAFATGSDDATCRL--FDLRADQELMTYSHDNI 269 +G +QT + + PN + FA GS + F+ D + + + Sbjct: 86 PDGTWKQTLVLLRLNRAATFVRWSPNEDKFAVGSGARVISVCYFEQENDWWVSKHLKRPL 145 Query: 270 ICGITSVSFSKSGRLLLAGYDDFNCNVWDAL----KADRAGVLAGHD------------- 312 I S+ + + LL AG D V A A + G Sbjct: 146 RSTILSLDWHPNNVLLAAGCADRKAYVLSAYVRDVDAKPEASVWGSRLPFNTVCAEYPSG 205 Query: 313 NRVSCLGVTDDGMAVATGSWDSFLKI 338 V +G + G A+A DS + I Sbjct: 206 GWVHAVGFSPSGNALAYAGHDSSVTI 231 Score = 74.7 bits (182), Expect = 6e-14, Method: Composition-based stats. Identities = 35/251 (13%), Positives = 83/251 (33%), Gaps = 33/251 (13%) Query: 46 RTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSY---TTNKVHAIPLRSSWVMT 102 + RT H + + W S +V+ SQD +++ T + + + Sbjct: 46 KHARTFSDHDKIVTCVDWAPKSNRIVTCSQDRNAYVYEKRPDGTWKQTLVLLRLNRAATF 105 Query: 103 CAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGY-LSCCRFLDDNQIVTS- 160 ++P+ + A G + S+ +E + VS+ L + + +N ++ + Sbjct: 106 VRWSPNEDKFAVGSGARVISV-CYFEQENDWWVSKHLKRPLRSTILSLDWHPNNVLLAAG 164 Query: 161 SGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQ 220 D + + V + P+ ++ S + Sbjct: 165 CADRKAYV--------------LSAYVRDVDAKPEASVWGS----------RLPFNTVCA 200 Query: 221 TFTGHESDINAICFFPNGNAFATGSDDATCRL--FDLRADQELMTYSHDNIICGITSVSF 278 + ++A+ F P+GNA A D++ + + + S+ + Sbjct: 201 EYPS-GGWVHAVGFSPSGNALAYAGHDSSVTIAYPSAPEQPPRALITVKLSQLPLRSLLW 259 Query: 279 SKSGRLLLAGY 289 + ++ AGY Sbjct: 260 ANESAIVAAGY 270 Score = 67.8 bits (164), Expect = 6e-12, Method: Composition-based stats. Identities = 41/255 (16%), Positives = 79/255 (30%), Gaps = 29/255 (11%) Query: 104 AYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLD-DNQIVTSSG 162 A+ N +Y + +R + H ++C + N+IVT S Sbjct: 18 AFNSQRTEFVTTTATNQVELYEQDGNG--WKHARTFSDHDKIVTCVDWAPKSNRIVTCSQ 75 Query: 163 DTTCALWDIE---TGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGM-- 217 D +++ T +QT + +P+ F G+ + + Sbjct: 76 DRNAYVYEKRPDGTWKQTLVLLRLNRAATFVRWSPNEDKFAVGSGARVISVCYFEQENDW 135 Query: 218 --CRQTFTGHESDINAICFFPNGNAFATGSDDA-----TCRLFDLRADQELMTYSHD--- 267 + S I ++ + PN A G D + + D+ A E + Sbjct: 136 WVSKHLKRPLRSTILSLDWHPNNVLLAAGCADRKAYVLSAYVRDVDAKPEASVWGSRLPF 195 Query: 268 NIIC-------GITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAG----VLAGHDNRVS 316 N +C + +V FS SG L D + + ++ + + Sbjct: 196 NTVCAEYPSGGWVHAVGFSPSGNALAYAGHDSSVTIAYPSAPEQPPRALITVKLSQLPLR 255 Query: 317 CLGVTDDGMAVATGS 331 L ++ VA G Sbjct: 256 SLLWANESAIVAAGY 270 Score = 67.0 bits (162), Expect = 1e-11, Method: Composition-based stats. Identities = 25/159 (15%), Positives = 52/159 (32%), Gaps = 9/159 (5%) Query: 188 MSLSLAPDTRLFVSGACDASAKLWDVREGMCRQ--TFTGHESDINAICFFPNGNAFATGS 245 + FV+ +L++ + TF+ H+ + + + P N T S Sbjct: 15 YEHAFNSQRTEFVTTTATNQVELYEQDGNGWKHARTFSDHDKIVTCVDWAPKSNRIVTCS 74 Query: 246 DDATCRLFDLRAD-QELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADR 304 D +++ R D T + T V +S + G +V + + Sbjct: 75 QDRNAYVYEKRPDGTWKQTLVLLRLNRAATFVRWSPNEDKFAVGSGARVISVC-YFEQEN 133 Query: 305 AGVLAGHDNR-----VSCLGVTDDGMAVATGSWDSFLKI 338 ++ H R + L + + +A G D + Sbjct: 134 DWWVSKHLKRPLRSTILSLDWHPNNVLLAAGCADRKAYV 172 Score = 47.0 bits (110), Expect = 1e-05, Method: Composition-based stats. Identities = 15/121 (12%), Positives = 34/121 (28%), Gaps = 5/121 (4%) Query: 220 QTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFS 279 Q F F T + L++ + + + +T V ++ Sbjct: 5 QVLHILPKPSYEHAFNSQRTEFVTTTATNQVELYEQDGNGWKHARTFSDHDKIVTCVDWA 64 Query: 280 KSGRLLLAGYDDFNCNVW----DALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSF 335 ++ D N V+ D +L + + + + + A GS Sbjct: 65 PKSNRIVTCSQDRNAYVYEKRPDGTWKQTLVLLRLN-RAATFVRWSPNEDKFAVGSGARV 123 Query: 336 L 336 + Sbjct: 124 I 124 Score = 43.9 bits (102), Expect = 1e-04, Method: Composition-based stats. Identities = 37/173 (21%), Positives = 62/173 (35%), Gaps = 32/173 (18%) Query: 43 IQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGK-------LI---------IWDSY- 85 + +R LR + I ++ W ++ LL + D K + +W S Sbjct: 137 VSKHLKRPLR---STILSLDWHPNNVLLAAGCADRKAYVLSAYVRDVDAKPEASVWGSRL 193 Query: 86 TTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGY 145 N V A WV ++PSGN +A G D+ +I E R + Sbjct: 194 PFNTVCAEYPSGGWVHAVGFSPSGNALAYAGHDSSVTIAYPSAPEQPPRALITVKLSQLP 253 Query: 146 LSCCRFLDDNQIVTSS-----------GDTTCALWDIETGQQTTTFTGHTGDV 187 L + +++ IV + D++ G T+FT HTG+ Sbjct: 254 LRSLLWANESAIVAAGYNYSPILLQGNESGWAHTRDLDAGTSKTSFT-HTGNT 305 >5YZG-2 nrPDB Length = 646 Score = 82.4 bits (202), Expect = 3e-16, Method: Composition-based stats. Identities = 38/236 (16%), Positives = 76/236 (32%), Gaps = 29/236 (12%) Query: 54 HLAKIYAMHWGTDSRLLVSASQDGKLIIWD--SYTTNKVHAIPLRSSWVMTCAYAPSGNY 111 H I + T + +++AS DG + W V + + A + G Sbjct: 89 HRDVITHVV-CTKTDFIITASHDGHVKFWKKIEEGIEFVKHFRSHLGVIESIAVSSEGAL 147 Query: 112 VACGGLDNICSIYNLKTREGNVRVSRE-LAGHTGYLSCCRFLDDNQIVT--SSGDTTCAL 168 G D ++++ + + G ++ C + I + +S +T + Sbjct: 148 FCSVGDDKAMKVFDVVNFDMINMLKLGYFPGQCEWIYC----PGDAISSVAASEKSTGKI 203 Query: 169 --WDIE-TGQQTTTFTG-HTGDVMSLSLAPDTRLFVSGACDASAKLW------------- 211 +D Q F HT + + L P + VS + W Sbjct: 204 FIYDGRGDNQPLHIFDKLHTSPLTQIRLNPVYKAVVSSDKSGMIEYWTGPPHEYKFPKNV 263 Query: 212 --DVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYS 265 + + F ++ ++CF P+G AT D R+F + + + Sbjct: 264 NWEYKTDTDLYEFAKCKAYPTSVCFSPDGKKIATIGSDRKVRIFRFVTGKLMRVFD 319 Score = 79.7 bits (195), Expect = 2e-15, Method: Composition-based stats. Identities = 38/224 (16%), Positives = 77/224 (34%), Gaps = 31/224 (13%) Query: 142 HTGYLSCCRFLDDNQIVTSSGDTTCALWD-IETG-QQTTTFTGHTGDVMSLSLAPDTRLF 199 H ++ + I+T+S D W IE G + F H G + S++++ + LF Sbjct: 89 HRDVITHVVCTKTDFIITASHDGHVKFWKKIEEGIEFVKHFRSHLGVIESIAVSSEGALF 148 Query: 200 VSGACDASAKLWDVREGMCRQTFT-----GHESDINAICFFPNGNAFAT--GSDDAT--C 250 S D + K++DV G I G+A ++ S+ +T Sbjct: 149 CSVGDDKAMKVFDVVNFDMINMLKLGYFPGQCEWIYC-----PGDAISSVAASEKSTGKI 203 Query: 251 RLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVW------------- 297 ++D R D + + +T + + + +++ W Sbjct: 204 FIYDGRGDNQPLHIFDKLHTSPLTQIRLNPVYKAVVSSDKSGMIEYWTGPPHEYKFPKNV 263 Query: 298 --DALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIW 339 + A + + + DG +AT D ++I+ Sbjct: 264 NWEYKTDTDLYEFAKCKAYPTSVCFSPDGKKIATIGSDRKVRIF 307 Score = 78.2 bits (191), Expect = 5e-15, Method: Composition-based stats. Identities = 29/253 (11%), Positives = 68/253 (26%), Gaps = 35/253 (13%) Query: 83 DSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGH 142 + + + + + + +++ D + K E + + H Sbjct: 76 NLPSASMYERSYMHRDVITHVVCTKT-DFIITASHDGHVKFW--KKIEEGIEFVKHFRSH 132 Query: 143 TGYLSCCRFLDDNQIV-TSSGDTTCALWDIETGQ-----QTTTFTGHTGDVMSLSLAPD- 195 G + + + + D ++D+ + F G + P Sbjct: 133 LGVIESIAVSSEGALFCSVGDDKAMKVFDVVNFDMINMLKLGYFPGQCEWIYC----PGD 188 Query: 196 --TRLFVSGACDASAKLWDVR-EGMCRQTFTG-HESDINAICFFPNGNAFATGSDDATCR 251 + + S ++D R + F H S + I P A + Sbjct: 189 AISSVAASEKSTGKIFIYDGRGDNQPLHIFDKLHTSPLTQIRLNPVYKAVVSSDKSGMIE 248 Query: 252 LF---------------DLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNV 296 + + + D +L ++ TSV FS G+ + D + Sbjct: 249 YWTGPPHEYKFPKNVNWEYKTDTDLYEFAKCKAYP--TSVCFSPDGKKIATIGSDRKVRI 306 Query: 297 WDALKADRAGVLA 309 + + V Sbjct: 307 FRFVTGKLMRVFD 319 Score = 72.4 bits (176), Expect = 3e-13, Method: Composition-based stats. Identities = 46/296 (15%), Positives = 91/296 (30%), Gaps = 45/296 (15%) Query: 51 LRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTN-----KVHAIPLRSSWVMTCAY 105 R HL I ++ ++ L S D + ++D + K+ P + W+ C Sbjct: 129 FRSHLGVIESIAVSSEGALFCSVGDDKAMKVFDVVNFDMINMLKLGYFPGQCEWIY-CPG 187 Query: 106 APSGNYVACGGLDNICSIYNLKTREGNVRVSREL-AGHTGYLSCCRFLDDNQIVTSSGDT 164 + A IY+ G+ + HT L+ R + V SS D Sbjct: 188 DAISSVAASEKSTGKIFIYD---GRGDNQPLHIFDKLHTSPLTQIRLNPVYKAVVSS-DK 243 Query: 165 TCAL-----------------WDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDAS 207 + + W+ +T F S+ +PD + + D Sbjct: 244 SGMIEYWTGPPHEYKFPKNVNWEYKTDTDLYEFAKCKAYPTSVCFSPDGKKIATIGSDRK 303 Query: 208 AKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHD 267 +++ G + F S + +L D+ + + Sbjct: 304 VRIFRFVTGKLMRVFDESLSMFTELQQMRQ-------------QLPDMEFGRRMAVEREL 350 Query: 268 NIICGI--TSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDN-RVSCLGV 320 + + ++ F ++G +L G V + +L +N RV L + Sbjct: 351 EKVDAVRLINIVFDETGHFVLYGTMLG-IKVINVETNRCVRILGKQENIRVMQLAL 405 Score = 45.4 bits (106), Expect = 3e-05, Method: Composition-based stats. Identities = 11/74 (14%), Positives = 28/74 (37%), Gaps = 3/74 (4%) Query: 269 IICGITSVSFSKSGRLLLAGYDDFNCNVWDALKA--DRAGVLAGHDNRVSCLGVTDDGMA 326 IT V +K+ ++ D + W ++ + H + + V+ +G Sbjct: 89 HRDVITHVVCTKT-DFIITASHDGHVKFWKKIEEGIEFVKHFRSHLGVIESIAVSSEGAL 147 Query: 327 VATGSWDSFLKIWN 340 + D +K+++ Sbjct: 148 FCSVGDDKAMKVFD 161 >5AMS-A nrPDB Length = 431 Score = 78.6 bits (192), Expect = 3e-15, Method: Composition-based stats. Identities = 51/308 (16%), Positives = 105/308 (34%), Gaps = 40/308 (12%) Query: 44 QMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTC 103 + TL G+ + + + ++ LV+A GK+++ + + V Sbjct: 98 PPKFAGTLTGYGESVISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEI 157 Query: 104 AYAPS----GNYVACGGLDNICSIYNLKTREGNVRVSRELAG--HTGYLSCCRFLDDNQ- 156 + + A G D S++ + E + + + ++G H S F++ ++ Sbjct: 158 VWLKTHPTIARTFAFGATDG--SVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKG 215 Query: 157 -----IVTSSGDTTCALWDIETGQQT-----TTFTGHTGDVMSLSLAP------DTRLFV 200 +VT S D+T W+ TGQQ G +SLSLAP ++ + Sbjct: 216 ENTLELVTCSLDSTIVAWNCFTGQQLFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVA 275 Query: 201 SGACDASAKLWDVREGMCRQTF----------TGHESDINAICFFPNGNAFATGSDDATC 250 G+ + + + G ++ I +I + + A G Sbjct: 276 CGSNNGLLAVINCNNGGAILHLSTVIELKPEQDELDASIESISWSSKFSLMAIGLVCGEI 335 Query: 251 RLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAG 310 L+D A + + ++ + + L A + ++A V G Sbjct: 336 LLYDTSAWRVRHKFVLEDSVTKLMF-----DNDDLFASCINGKVYQFNARTGQEKFVCVG 390 Query: 311 HDNRVSCL 318 H+ V Sbjct: 391 HNMGVLDF 398 Score = 71.6 bits (174), Expect = 4e-13, Method: Composition-based stats. Identities = 40/309 (12%), Positives = 99/309 (32%), Gaps = 35/309 (11%) Query: 54 HLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVH--AIPLRSSWVMTCAYAPSGNY 111 H ++A+ + L+ + D +W S++ + V++C++ G + Sbjct: 64 HTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGF 123 Query: 112 VACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDD--NQIVTSSGDTTCALW 169 + + ++ + +++ ++ + + + D + + Sbjct: 124 LVTADMSGKVLVHMGQKGGAQWKLASQMQ-EVEEIVWLKTHPTIARTFAFGATDGSVWCY 182 Query: 170 DI--ETGQQTTTFTG--HTGDVMSLSLAP-----DTRLFVSGACDASAKLWDVREGM--- 217 I + G +G H D +T V+ + D++ W+ G Sbjct: 183 QINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNCFTGQQLF 242 Query: 218 --CRQTFTGHESDINAICFFP------NGNAFATGSDDATCRLFDLRADQELMTYS---- 265 + G E+ ++ P N A GS++ + + ++ S Sbjct: 243 KITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSNNGLLAVINCNNGGAILHLSTVIE 302 Query: 266 ----HDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVT 321 D + I S+S+S L+ G ++D ++ V+ L Sbjct: 303 LKPEQDELDASIESISWSSKFSLMAIGLVCGEILLYDTSAWRVRHKFVL-EDSVTKLMFD 361 Query: 322 DDGMAVATG 330 +D A+ Sbjct: 362 ND-DLFASC 369 Score = 69.7 bits (169), Expect = 1e-12, Method: Composition-based stats. Identities = 40/240 (16%), Positives = 79/240 (32%), Gaps = 25/240 (10%) Query: 86 TTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGY 145 + N + + V + P+ V GG DN+ ++ + + + L G+ Sbjct: 54 SNNSLTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWT--SHSQPPKFAGTLTGYGES 111 Query: 146 LSCCRF-LDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSL---APD-TRLFV 200 + C F + +VT+ + + G +V + P R F Sbjct: 112 VISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFA 171 Query: 201 SGACDASAKLWDVRE--GMCRQTFTG--HESDINAICFFPNGN-----AFATGSDDATCR 251 GA D S + + E G Q +G H+ D + F T S D+T Sbjct: 172 FGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIV 231 Query: 252 LFDLRADQELMTYSH---DNIICGITSVSFSK------SGRLLLAGYDDFNCNVWDALKA 302 ++ Q+L + + S+S + + ++ G ++ V + Sbjct: 232 AWNCFTGQQLFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSNNGLLAVINCNNG 291 Score = 59.3 bits (142), Expect = 2e-09, Method: Composition-based stats. Identities = 31/181 (17%), Positives = 57/181 (31%), Gaps = 13/181 (7%) Query: 173 TGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQ--TFTGHESDIN 230 + T F HT V ++ P+ L +G D A LW + T TG+ + Sbjct: 54 SNNSLTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVI 113 Query: 231 AICFFPNGNAFATGSDDATCRL-FDLRADQELMTYSHDNIICGITSVSFSKS-GRLLLAG 288 + F G T + + + S + I + + R G Sbjct: 114 SCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFG 173 Query: 289 YDDFNCNVWDALK--ADRAGVLAG--HD-----NRVSCLGVTDDGMAVATGSWDSFLKIW 339 D + + + +++G H ++ + + T S DS + W Sbjct: 174 ATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAW 233 Query: 340 N 340 N Sbjct: 234 N 234 Score = 48.5 bits (114), Expect = 5e-06, Method: Composition-based stats. Identities = 25/132 (18%), Positives = 37/132 (28%), Gaps = 7/132 (5%) Query: 212 DVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIIC 271 D+ F H + AI PN TG D L+ + + Sbjct: 52 DMSNNSLTY-FDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGE 110 Query: 272 GITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVAT-- 329 + S SF+ G L+ V K LA V + +A Sbjct: 111 SVISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTF 170 Query: 330 --GSWDSFLKIW 339 G+ D + W Sbjct: 171 AFGATDGSV--W 180 >5MC6-j nrPDB Length = 397 Score = 75.1 bits (183), Expect = 4e-14, Method: Composition-based stats. Identities = 60/330 (18%), Positives = 108/330 (32%), Gaps = 64/330 (19%) Query: 52 RGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDS-----------YTTNKVHAIPLRSSWV 100 + H A I+++ + VS S DG L +WD+ ++ VH L V Sbjct: 13 KAHDADIFSV--SACNSFTVSCSGDGYLKVWDNKLLDNENPKDKSYSHFVHKSGLHHVDV 70 Query: 101 MTCAYAP--SGNYVACGGLDNICSIYNLKTREGNVRVS--------RELAGHTGYLSCCR 150 + VA Y + + +V ++ H+ + + Sbjct: 71 LQAIERDAFELCLVATTSFSGDLLFYRITREDETKKVIFEKLDLLDSDMKKHSFW--ALK 128 Query: 151 FLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKL 210 + N + S D++ F + SL+L L + G Sbjct: 129 WGASNDRLLSHR---LVATDVKGTTYIWKFHPFADESNSLTLNWSPTLELQGT------- 178 Query: 211 WDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNII 270 V M F ++ G ATG ++ T ++ +L + L + + + Sbjct: 179 --VESPMTPSQFA------TSVDISERG-LIATGFNNGTVQISELSTLRPLYNFESQHSM 229 Query: 271 CG----ITSVSFSKSGRLLLAGYDDFN---CNVWDALKADRAGVLA-------------G 310 I SV FS G LL +D + +++ +R G L+ Sbjct: 230 INNSNSIRSVKFSPQGSLLAIAHDSNSFGCITLYETEFGERIGSLSVPTHSSQASLGEFA 289 Query: 311 HDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 H + V L D G + + WD L+ W+ Sbjct: 290 HSSWVMSLSFNDSGETLCSAGWDGKLRFWD 319 Score = 67.0 bits (162), Expect = 1e-11, Method: Composition-based stats. Identities = 40/213 (18%), Positives = 71/213 (33%), Gaps = 43/213 (20%) Query: 59 YAMHWGTDSRLLVS---ASQD--GKLIIW---------DSYTTNKVHAIPLR-------- 96 +A+ WG + L+S + D G IW +S T N + L+ Sbjct: 125 WALKWGASNDRLLSHRLVATDVKGTTYIWKFHPFADESNSLTLNWSPTLELQGTVESPMT 184 Query: 97 -SSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVS--RELAGHTGYLSCCRFLD 153 S + + + G +A G + I L T + ++ + +F Sbjct: 185 PSQFATSVDISERG-LIATGFNNGTVQISELSTLRPLYNFESQHSMINNSNSIRSVKFSP 243 Query: 154 DNQIVTSSGDTT----CALWDIETGQQTTTFT-------------GHTGDVMSLSLAPDT 196 ++ + D+ L++ E G++ + + H+ VMSLS Sbjct: 244 QGSLLAIAHDSNSFGCITLYETEFGERIGSLSVPTHSSQASLGEFAHSSWVMSLSFNDSG 303 Query: 197 RLFVSGACDASAKLWDVREGMCRQTFTGHESDI 229 S D + WDV+ T H DI Sbjct: 304 ETLCSAGWDGKLRFWDVKTKERITTLNMHCDDI 336 Score = 48.5 bits (114), Expect = 4e-06, Method: Composition-based stats. Identities = 11/48 (22%), Positives = 21/48 (43%) Query: 53 GHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWV 100 H + + ++ + L SA DGKL WD T ++ + + + Sbjct: 289 AHSSWVMSLSFNDSGETLCSAGWDGKLRFWDVKTKERITTLNMHCDDI 336 >5K19-A nrPDB Length = 569 Score = 73.6 bits (179), Expect = 1e-13, Method: Composition-based stats. Identities = 34/194 (17%), Positives = 66/194 (34%), Gaps = 20/194 (10%) Query: 55 LAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVAC 114 + + D + L SQDG L +++ + + ++ ++P G Y+ Sbjct: 220 EGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVT 279 Query: 115 GGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLD--------DNQIVTSSGD--T 164 GG D++ ++++ + RV GH ++S F D + S + Sbjct: 280 GGEDDLVTVWSFV----DCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQ 335 Query: 165 TCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREG-----MCR 219 + + T + S ++ T F S D LWD+ E Sbjct: 336 DLLHFGRDRANSTQSRLSKRNSTDSRPVS-VTYRFGSVGQDTQLCLWDLTEDILFPHQPL 394 Query: 220 QTFTGHESDINAIC 233 H + +NA Sbjct: 395 SRARTHTNVMNATS 408 Score = 73.2 bits (178), Expect = 2e-13, Method: Composition-based stats. Identities = 36/217 (16%), Positives = 65/217 (29%), Gaps = 42/217 (19%) Query: 156 QIVTSSGDTTCALWDIETGQQTTTFTGHT----GDVMSLSLAPDT-RLFVSGACDASAKL 210 ++ L D + + F V + P + LF+ + L Sbjct: 117 SLLVGFSAGQVQLIDPIKKETSKLFNEERLIDKSRVTCVKWVPGSESLFLVAHSSGNMYL 176 Query: 211 WDVR----------------------------EGMCRQTFTGHESDINAICFFPNGNAFA 242 ++V +T E +N F P+G A Sbjct: 177 YNVEHTCGTTAPHYQLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLA 236 Query: 243 TGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKA 302 S D R+F+ + + T + G+ V +S G+ ++ G +D VW + Sbjct: 237 CVSQDGFLRVFNFDSVELHGTM--KSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDC 294 Query: 303 DRAGVLAGHDNRVSCLGVTDDGMAV-------ATGSW 332 GH + VS + +V +GS Sbjct: 295 RVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSD 331 Score = 70.9 bits (172), Expect = 8e-13, Method: Composition-based stats. Identities = 48/315 (15%), Positives = 90/315 (28%), Gaps = 51/315 (16%) Query: 20 DARKACADATLSQITNNIDPVGRIQMRTRRTLRG----HLAKIYAMHWGTDS-RLLVSAS 74 A + + + I+ T + +++ + W S L + A Sbjct: 110 TATAESVSLLVGFSAGQVQLIDPIKKETSKLFNEERLIDKSRVTCVKWVPGSESLFLVAH 169 Query: 75 QDGKLIIWDSY----------------------------TTNKVHAIPLRSSWVMTCAYA 106 G + +++ T N + + + A++ Sbjct: 170 SSGNMYLYNVEHTCGTTAPHYQLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFS 229 Query: 107 PSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQ-IVTSSGDTT 165 P G ++AC D ++N + V + + + G L C + D + IVT D Sbjct: 230 PDGKFLACVSQDGFLRVFNFDS----VELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDL 285 Query: 166 CALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLF-------VSGAC-DASAKLWDVREGM 217 +W + GH V ++ P T SG+ D L R+ Sbjct: 286 VTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFGRDRA 345 Query: 218 CRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRAD-----QELMTYSHDNIICG 272 + + F + D L+DL D Q L + Sbjct: 346 NSTQSRLSKRNSTDSRPVSVTYRFGSVGQDTQLCLWDLTEDILFPHQPLSRARTHTNVMN 405 Query: 273 ITSVSFSKSGRLLLA 287 TS +G + Sbjct: 406 ATSPPAGSNGNSVTT 420 >2I3T-A nrPDB Length = 341 Score = 73.2 bits (178), Expect = 2e-13, Method: Composition-based stats. Identities = 45/313 (14%), Positives = 98/313 (31%), Gaps = 36/313 (11%) Query: 55 LAKIYAMHWGTDSRLLVSASQDG--KLIIWDSYTTNKVHAIPLRSSWVMTCA--YAPSGN 110 I + LL+ S DG + +D N LR + C + Sbjct: 11 KDYISDIKIIPSKSLLLITSWDGSLTVYKFDIQAKNVDLLQSLRYKHPLLCCNFIDNTDL 70 Query: 111 YVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWD 170 + G + +L + + + G C++ DD +++ +S D + D Sbjct: 71 QIYVGTVQGEILKVDL-IGSPSFQALTNNEANLGICRICKYGDD-KLIAASWDGLIEVID 128 Query: 171 IETGQQ----TTTFTGHTGDVMS--LSLAPDTRLFVSGACDASAK-----LWDVREGMCR 219 + V + ++ ++ + G ++ + L + G Sbjct: 129 PRNYGDGVIAVKNLNSNNTKVKNKIFTMDTNSSRLIVGMNNSQVQWFRLPLCEDDNGTIE 188 Query: 220 QTFTGHESDINAICFFPNGNA-FATGSDDATCRLF-------DLRADQELMTYSH----- 266 ++ G + I + P +A S D + D + + H Sbjct: 189 ES--GLKYQIRDVALLPKEQEGYACSSIDGRVAVEFFDDQGDDYNSSKRFAFRCHRLNLK 246 Query: 267 -DNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVL-AGHDNRVSCLGVTDDG 324 N+ + S+ FS + L D + W+ + +++ V + +D+ Sbjct: 247 DTNLAYPVNSIEFSPRHKFLYTAGSDGIISCWNLQTRKKIKNFAKFNEDSVVKIACSDNI 306 Query: 325 MAVATGSWDSFLK 337 + +AT D K Sbjct: 307 LCLATS--DDTFK 317 Score = 57.4 bits (137), Expect = 9e-09, Method: Composition-based stats. Identities = 39/281 (13%), Positives = 81/281 (28%), Gaps = 31/281 (11%) Query: 88 NKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLS 147 V ++ PS + + D ++Y + NV + + L + L Sbjct: 2 QIVQIEQAPKDYISDIKIIPSKSLLLITSWDGSLTVYKFDIQAKNVDLLQSLR-YKHPLL 60 Query: 148 CCRFLDDNQI-----VTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSG 202 CC F+D+ + L + Q T + G D ++ Sbjct: 61 CCNFIDNTDLQIYVGTVQGEILKVDLIGSPSFQALTNNEANLGICRICKYGDD--KLIAA 118 Query: 203 ACDASAKLWDVRE----GMCRQTFTGHESDINAICF--FPNGNAFATGSDDATCRLFDLR 256 + D ++ D R + + + + + F N + G +++ + F L Sbjct: 119 SWDGLIEVIDPRNYGDGVIAVKNLNSNNTKVKNKIFTMDTNSSRLIVGMNNSQVQWFRLP 178 Query: 257 A-DQELMTYSHDNIICGITSVSFSKSGRLLLAGYD-DFNCNV------WDALKADRAGVL 308 + + T + I V+ + A D V D + + Sbjct: 179 LCEDDNGTIEESGLKYQIRDVALLPKEQEGYACSSIDGRVAVEFFDDQGDDYNSSKRFAF 238 Query: 309 AGHDNR---------VSCLGVTDDGMAVATGSWDSFLKIWN 340 H V+ + + + T D + WN Sbjct: 239 RCHRLNLKDTNLAYPVNSIEFSPRHKFLYTAGSDGIISCWN 279 >5LTD-A nrPDB Length = 525 Score = 71.3 bits (173), Expect = 6e-13, Method: Composition-based stats. Identities = 37/287 (12%), Positives = 90/287 (31%), Gaps = 33/287 (11%) Query: 55 LAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVAC 114 I ++ D VS I++ + ++ S ++ ++ S + Sbjct: 31 NDNINFANFNQDFSC-VSVGYSNGYKIYNCEPFGQCYSKSDGSIGIVEMLFSSSLLAIVG 89 Query: 115 GGLDNIC---SIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDI 171 G + + + T+ G + + + +V + T ++DI Sbjct: 90 MGEQHSLSPRRLKIINTKRQTTICELTFPG---AILAVKLNRERLVVL--LEETIYIYDI 144 Query: 172 ETGQQTTTFTGHTGDVMSLSLAP--DTRLFVSGA---------------------CDASA 208 + T + ++L+P + + + Sbjct: 145 NNMRLLHTIETPSNPNGLIALSPSSENNYLAYPSPQKLAPNPQTEVTLHSNPQTVRNGDV 204 Query: 209 KLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATC-RLFDLRADQELMTYSHD 267 ++D + H + + AI +G AT SD T R+F + +L + Sbjct: 205 IIFDAKTLQPTSVIEAHRTSLAAIALSKDGLLLATASDKGTIIRVFSVATGIKLYQFRRG 264 Query: 268 NIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNR 314 I S++FS R ++A +++ + + A + + + Sbjct: 265 TYPTKIYSLAFSPDNRFVIASSATETVHIFRLGEEEAANTIKSANKK 311 Score = 60.1 bits (144), Expect = 1e-09, Method: Composition-based stats. Identities = 33/203 (16%), Positives = 69/203 (33%), Gaps = 25/203 (12%) Query: 78 KLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSR 137 + I+D +H I S+ A +PS +N + + + N + Sbjct: 138 TIYIYDINNMRLLHTIETPSNPNGLIALSPS-------SENNYLAYPSPQKLAPNPQTEV 190 Query: 138 ELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTR 197 L H+ + + ++D +T Q T+ H + +++L+ D Sbjct: 191 TL--HSNPQTV-------------RNGDVIIFDAKTLQPTSVIEAHRTSLAAIALSKDGL 235 Query: 198 LFVSGACDAS-AKLWDVREGMCRQTFTGHESD--INAICFFPNGNAFATGSDDATCRLFD 254 L + + + +++ V G+ F I ++ F P+ S T +F Sbjct: 236 LLATASDKGTIIRVFSVATGIKLYQFRRGTYPTKIYSLAFSPDNRFVIASSATETVHIFR 295 Query: 255 LRADQELMTYSHDNIICGITSVS 277 L ++ T N +T Sbjct: 296 LGEEEAANTIKSANKKARLTKAQ 318 Score = 57.4 bits (137), Expect = 8e-09, Method: Composition-based stats. Identities = 33/278 (11%), Positives = 79/278 (28%), Gaps = 43/278 (15%) Query: 94 PLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLD 153 P ++ + + + V+ G + Y + E + + G G + F Sbjct: 28 PRKNDNINFANFNQDFSCVSVGYSNG----YKIYNCEPFGQCYSKSDGSIGIVEML-FSS 82 Query: 154 DNQIVTSSGD------TTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDAS 207 + G+ + + + T G ++++ L + + + + + Sbjct: 83 SLLAIVGMGEQHSLSPRRLKIINTKRQTTICELTF-PGAILAVKLNRERLVVL---LEET 138 Query: 208 AKLWDVREGMCRQTFT--GHESDINAICFFPNGNAFATGS-------------------- 245 ++D+ T + + + A+ N A S Sbjct: 139 IYIYDINNMRLLHTIETPSNPNGLIALSPSSENNYLAYPSPQKLAPNPQTEVTLHSNPQT 198 Query: 246 -DDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNC-NVWDALKAD 303 + +FD + Q + +++ SK G LL D V+ Sbjct: 199 VRNGDVIIFDAKTLQPTSVIEA--HRTSLAAIALSKDGLLLATASDKGTIIRVFSVATGI 256 Query: 304 RAGVLAGHD--NRVSCLGVTDDGMAVATGSWDSFLKIW 339 + ++ L + D V S + I+ Sbjct: 257 KLYQFRRGTYPTKIYSLAFSPDNRFVIASSATETVHIF 294 Score = 50.1 bits (118), Expect = 1e-06, Method: Composition-based stats. Identities = 16/95 (16%), Positives = 34/95 (35%), Gaps = 3/95 (3%) Query: 40 VGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGK-LIIWDSYTTNKVHAIP--LR 96 ++ + H + A+ D LL +AS G + ++ T K++ Sbjct: 207 FDAKTLQPTSVIEAHRTSLAAIALSKDGLLLATASDKGTIIRVFSVATGIKLYQFRRGTY 266 Query: 97 SSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREG 131 + + + A++P +V I+ L E Sbjct: 267 PTKIYSLAFSPDNRFVIASSATETVHIFRLGEEEA 301 >5TF2-A nrPDB Length = 407 Score = 70.5 bits (171), Expect = 1e-12, Method: Composition-based stats. Identities = 34/204 (16%), Positives = 55/204 (26%), Gaps = 38/204 (18%) Query: 61 MHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNI 120 + + D+ LL + DG + +W + KV + A P G V G D Sbjct: 178 VCFNHDNTLLATGGTDGYVRVWKVPSLEKVLEFKAHEGEIEDLALGPDGKLVTVG-RDLK 236 Query: 121 CSIY---NLKTREGNVRVSRELAGHTGYLSCCRF-----------------------LDD 154 S++ L T+ + CRF Sbjct: 237 ASVWQKDQLVTQLHWQENGPTFSSTPYRYQACRFGQVPDQPAGLRLFTVQIPHKRLRQPP 296 Query: 155 NQIVTSSGDTTCALWDIETGQQTTTFT-GHTGDVMSLSLAPDTRLFVSGACDASAKLWDV 213 +T+ WD T + GH V L ++ G S ++ Sbjct: 297 PCYLTA--------WDGSNFLPLRTKSCGHE-VVSCLDVSESGTFLGLGTVTGSVAIYIA 347 Query: 214 REGMCR-QTFTGHESDINAICFFP 236 C H + + F P Sbjct: 348 FSLQCLYYVREAHGIVVTDVAFLP 371 Score = 65.5 bits (158), Expect = 3e-11, Method: Composition-based stats. Identities = 31/166 (18%), Positives = 48/166 (28%), Gaps = 26/166 (15%) Query: 190 LSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDAT 249 + D L +G D ++W V F HE +I + P+G T D Sbjct: 178 VCFNHDNTLLATGGTDGYVRVWKVPSLEKVLEFKAHEGEIEDLALGPDGK-LVTVGRDLK 236 Query: 250 CRLFD----------LRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFN------ 293 ++ + + C V +G L Sbjct: 237 ASVWQKDQLVTQLHWQENGPTFSSTPYRYQACRFGQVPDQPAGLRLFTVQIPHKRLRQPP 296 Query: 294 ---CNVWDALKADRAGVLA-GHDNRVSCLGVTDDGMAV----ATGS 331 WD + GH+ VSCL V++ G + TGS Sbjct: 297 PCYLTAWDGSNFLPLRTKSCGHE-VVSCLDVSESGTFLGLGTVTGS 341 Score = 56.6 bits (135), Expect = 1e-08, Method: Composition-based stats. Identities = 17/81 (20%), Positives = 26/81 (32%), Gaps = 2/81 (2%) Query: 261 LMTYSHDNIICGITSVS-FSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLG 319 L D + V F+ LL G D VW ++ H+ + L Sbjct: 162 LQAVQTDFSSDPLQKVVCFNHDNTLLATGGTDGYVRVWKVPSLEKVLEFKAHEGEIEDLA 221 Query: 320 VTDDGMAVATGSWDSFLKIWN 340 + DG + T D +W Sbjct: 222 LGPDGK-LVTVGRDLKASVWQ 241 >5AJA-A nrPDB Length = 361 Score = 65.9 bits (159), Expect = 2e-11, Method: Composition-based stats. Identities = 39/236 (16%), Positives = 81/236 (34%), Gaps = 27/236 (11%) Query: 59 YAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVA-CGGL 117 + R L+ + G+L +++ ++ + + +S + + G+ + Sbjct: 41 TCCAFSARERFLMLGTCTGQLKLYNVFSGQEEASYNCHNSAITHLEPSRDGSLLLTSATW 100 Query: 118 DNICS-IYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQ 176 S ++ +K+ + Y+ + D I T ++DI+TG + Sbjct: 101 SQPLSALWGMKS---VFDMKHSFT-EDHYVEFSKHSQDRVIGTKGD--IAHIYDIQTGNK 154 Query: 177 TTTF----TGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAI 232 T + + P L + D LWDVR F +I+ + Sbjct: 155 LLTLFNPDLANNYKRNCATFNPTDDLVL---NDGV--LWDVRSAQAIHKFDKFNMNISGV 209 Query: 233 CFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAG 288 F PNG ++ ++DLR L T + V F+ +G ++ Sbjct: 210 -FHPNGLEVIINTE-----IWDLRTFHLLHTVPALDQC----RVVFNHTGTVMYGA 255 Score = 53.9 bits (128), Expect = 1e-07, Method: Composition-based stats. Identities = 30/191 (15%), Positives = 61/191 (31%), Gaps = 23/191 (12%) Query: 44 QMRTRRTLRG--------HLAKIYAMHWGTDSRLLV-SASQDGKLI-IWDSYTTNKVHAI 93 Q++ G H + I + D LL+ SA+ L +W + + Sbjct: 60 QLKLYNVFSGQEEASYNCHNSAITHLEPSRDGSLLLTSATWSQPLSALWGMKSVFDMKHS 119 Query: 94 PLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLD 153 +V ++ G +I IY+++T + + + +C F Sbjct: 120 FTEDHYV---EFSKHSQDRVIGTKGDIAHIYDIQTGNKLLTLFNPDLANNYKRNCATFNP 176 Query: 154 DNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDV 213 + +V LWD+ + Q F ++ + P+ + +WD+ Sbjct: 177 TDDLVL----NDGVLWDVRSAQAIHKFDKFNMNISGV-FHPNGLEVIINTE-----IWDL 226 Query: 214 REGMCRQTFTG 224 R T Sbjct: 227 RTFHLLHTVPA 237 Score = 53.2 bits (126), Expect = 2e-07, Method: Composition-based stats. Identities = 39/259 (15%), Positives = 77/259 (29%), Gaps = 76/259 (29%) Query: 115 GGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIV---TSSGDTTCALWDI 171 G D + +R + V RE +CC F + + T +G L+++ Sbjct: 13 GCFDRHL----IFSRFRPISVFREANEDESGFTCCAFSARERFLMLGTCTG--QLKLYNV 66 Query: 172 ETGQQTTTFTGHTGDVMSLSLAPDTRLFVSG----------------------------- 202 +GQ+ ++ H + L + D L ++ Sbjct: 67 FSGQEEASYNCHNSAITHLEPSRDGSLLLTSATWSQPLSALWGMKSVFDMKHSFTEDHYV 126 Query: 203 -----ACDASA-------KLWDVREGMCRQTF----TGHESDINAICFFPNGNAFATGSD 246 + D ++D++ G T + N F P + + Sbjct: 127 EFSKHSQDRVIGTKGDIAHIYDIQTGNKLLTLFNPDLANNYKRNCATFNPTDDLVL---N 183 Query: 247 DATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAG 306 D L+D+R+ Q + + D I+ V F +G ++ + +WD Sbjct: 184 DGV--LWDVRSAQAIHKF--DKFNMNISGV-FHPNGLEVIINTE-----IWDLRTFHLLH 233 Query: 307 VLAG---------HDNRVS 316 + H V Sbjct: 234 TVPALDQCRVVFNHTGTVM 252 Score = 52.4 bits (124), Expect = 3e-07, Method: Composition-based stats. Identities = 24/159 (15%), Positives = 54/159 (33%), Gaps = 16/159 (10%) Query: 188 MSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSD- 246 + + R + G C KL++V G ++ H S I + +G+ T + Sbjct: 41 TCCAFSARERFLMLGTCTGQLKLYNVFSGQEEASYNCHNSAITHLEPSRDGSLLLTSATW 100 Query: 247 -DATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRA 305 L+ +++ + + V FSK + + G +++D ++ Sbjct: 101 SQPLSALWGMKS-----VFDMKHSFTEDHYVEFSKHSQDRVIGTKGDIAHIYDIQTGNKL 155 Query: 306 GVLA----GHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340 L ++ + +C V D +W+ Sbjct: 156 LTLFNPDLANNYKRNCATFNPTDDLVL---NDGV--LWD 189 >6IYY-A nrPDB Length = 317 Score = 64.7 bits (156), Expect = 6e-11, Method: Composition-based stats. Identities = 28/204 (13%), Positives = 68/204 (33%), Gaps = 9/204 (4%) Query: 142 HTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSL-APDTRLFV 200 H L F D+ + +++ + ++ G V + + L + Sbjct: 6 HGNGLLYAGFNQDHGCFACGMENGFRVYNTDPLKEKEKQEFLEGGVGHVEMLFRCNYLAL 65 Query: 201 SGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRAD-Q 259 G +WD + +++ A+ + D+ ++F + Sbjct: 66 VGGGKKKVMIWDDLKKKTVIEIE-FSTEVKAVKLRRDRIVVV---LDSMIKVFTFTHNPH 121 Query: 260 ELMTY-SHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGV-LAGHDNRVSC 317 +L + + N S + L G + + D ++ V + H+ +SC Sbjct: 122 QLHVFETCYNPKGLCVLCPNSNNSLLAFPGTHTGHVQLVDLASTEKPPVDIPAHEGVLSC 181 Query: 318 LGVTDDGMAVATGSWDSF-LKIWN 340 + + G +AT S ++I++ Sbjct: 182 IALNLQGTRIATASEKGTLIRIFD 205 Score = 63.2 bits (152), Expect = 1e-10, Method: Composition-based stats. Identities = 40/290 (13%), Positives = 74/290 (25%), Gaps = 32/290 (11%) Query: 63 WGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVA-CGGLDNIC 121 + D + ++++ + V NY+A GG Sbjct: 15 FNQDHGCFA-CGMENGFRVYNTDPLKEKEKQEFLEGGVGHVEMLFRCNYLALVGGGKKKV 73 Query: 122 SIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFT 181 I++ + F + + V D + D T T Sbjct: 74 MIWDDLK--------------KKTVIEIEFSTEVKAVKLRRDRIVVVLDSMIKVFTFTHN 119 Query: 182 GHTGDVMSLSLAP-----------DTRLFVSGACDASAKLWDV-REGMCRQTFTGHESDI 229 H V P ++ L G +L D+ HE + Sbjct: 120 PHQLHVFETCYNPKGLCVLCPNSNNSLLAFPGTHTGHVQLVDLASTEKPPVDIPAHEGVL 179 Query: 230 NAICFFPNGNAFATGSDDAT-CRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAG 288 + I G AT S+ T R+FD + + + I ++F++ L+ Sbjct: 180 SCIALNLQGTRIATASEKGTLIRIFDTSSGHLIQELRRGSQAANIYCINFNQDASLICVS 239 Query: 289 YDDFNCNVW---DALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSF 335 D +++ D + AV D Sbjct: 240 SDHGTVHIFAAEDPKSKWSFSKFQVPSGSPCICAFGTEPNAVIAICADGS 289 Score = 59.7 bits (143), Expect = 2e-09, Method: Composition-based stats. Identities = 36/262 (13%), Positives = 78/262 (29%), Gaps = 37/262 (14%) Query: 96 RSSWVMTCAYAPSGNYVACGGLDNICSIYNLK--TREGNVRVSRELAGHTGYLSCCRFLD 153 + ++ + ACG + +YN + GH L C +L Sbjct: 6 HGNGLLYAGFNQDHGCFACGMENGF-RVYNTDPLKEKEKQEFLEGGVGHVEMLFRCNYLA 64 Query: 154 DNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDV 213 + G +WD + T +V ++ L D + V D+ K++ Sbjct: 65 ----LVGGGKKKVMIWDDLKKKTVIEIEFST-EVKAVKLRRDRIVVV---LDSMIKVFTF 116 Query: 214 REGMCRQTFTGHESDINAICFFPNGNAFAT-----------GSDDATCRLFDLRA--DQE 260 H+ + C+ P G G+ +L DL + Sbjct: 117 THN-------PHQLHVFETCYNPKGLCVLCPNSNNSLLAFPGTHTGHVQLVDLASTEKPP 169 Query: 261 LMTYSHDNIICGITSVSFSKSGRLLLAGYDDFN-CNVWDALKADRAGVLA--GHDNRVSC 317 + +H+ + ++ ++ + G + + ++D L + C Sbjct: 170 VDIPAHEGV---LSCIALNLQGTRIATASEKGTLIRIFDTSSGHLIQELRRGSQAANIYC 226 Query: 318 LGVTDDGMAVATGSWDSFLKIW 339 + D + S + I+ Sbjct: 227 INFNQDASLICVSSDHGTVHIF 248 Score = 50.8 bits (120), Expect = 9e-07, Method: Composition-based stats. Identities = 12/116 (10%), Positives = 36/116 (31%), Gaps = 3/116 (2%) Query: 53 GHLAKIYAMHWGTDSRLLVSASQDGK-LIIWDSYTTNKVHAIPLRSSW--VMTCAYAPSG 109 H + + + +AS+ G + I+D+ + + + + S + + Sbjct: 174 AHEGVLSCIALNLQGTRIATASEKGTLIRIFDTSSGHLIQELRRGSQAANIYCINFNQDA 233 Query: 110 NYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTT 165 + + I+ + + S+ C + N ++ D + Sbjct: 234 SLICVSSDHGTVHIFAAEDPKSKWSFSKFQVPSGSPCICAFGTEPNAVIAICADGS 289 >5WLC-LL nrPDB Length = 643 Score = 64.7 bits (156), Expect = 6e-11, Method: Composition-based stats. Identities = 39/210 (18%), Positives = 80/210 (38%), Gaps = 13/210 (6%) Query: 51 LRGHLAKIYAMHW----GTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSW-VMTCAY 105 L K+ + W +D+ ++ +G++ ++ + +S+ + Sbjct: 53 LEDSKLKVTCLKWVNLASSDTVAIILGMNNGEIWLYSVLANEVTYKFTTGNSYEIKDIDL 112 Query: 106 APSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDD-NQIVTSSGDT 164 GN + C + ++L + L+ D Q++ +S Sbjct: 113 --MGNQLWCIDSSDAFYQFDLLQFKLLQHFRINNCVQLNKLTIVPAGDSVAQLLVAS--H 168 Query: 165 TCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGAC-DASAKLWDVREGMCRQTFT 223 + +L DIE + TF GH V +L + F+SGA D ++D+ GM + Sbjct: 169 SISLIDIEEKKVVMTFPGHVSPVSTLQVIT-NEFFISGAEGDRFLNVYDIHSGMTKCVLV 227 Query: 224 GHESDINAICFFPNGNAFATGSDDATCRLF 253 ESDI + ++ A ++D + +F Sbjct: 228 A-ESDIKELSHSGQADSIAVTTEDGSLEIF 256 Score = 46.6 bits (109), Expect = 2e-05, Method: Composition-based stats. Identities = 30/241 (12%), Positives = 76/241 (31%), Gaps = 24/241 (9%) Query: 65 TDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAY----APSGNYVACGGLDNI 120 ++ S+ D +W+ + V + + + G + Sbjct: 32 QPTQRATSSGVD---TVWN----ENFLYLEDSKLKVTCLKWVNLASSDTVAIILGMNNGE 84 Query: 121 CSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTF 180 +Y++ E + + G++ + + + S D +D+ + F Sbjct: 85 IWLYSVLANEVTYKFT---TGNSYEIKDIDLMGNQLWCIDSSD-AFYQFDLLQFKLLQHF 140 Query: 181 T-GHTGDVMSLSLAPDTR---LFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFP 236 + + L++ P + + S L D+ E TF GH S ++ + Sbjct: 141 RINNCVQLNKLTIVPAGDSVAQLLVAS--HSISLIDIEEKKVVMTFPGHVSPVSTLQVIT 198 Query: 237 NGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNV 296 N + D ++D+ + ++ I +S S + +D + + Sbjct: 199 NEFFISGAEGDRFLNVYDIHSGMTKCVLVAESD---IKELSHSGQADSIAVTTEDGSLEI 255 Query: 297 W 297 + Sbjct: 256 F 256 Score = 34.7 bits (78), Expect = 0.057, Method: Composition-based stats. Identities = 13/91 (14%), Positives = 38/91 (41%), Gaps = 1/91 (1%) Query: 34 TNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAI 93 +++I + + + T GH++ + + T+ + A D L ++D ++ + Sbjct: 167 SHSISLIDIEEKKVVMTFPGHVSPVSTLQVITNEFFISGAEGDRFLNVYDIHSGM-TKCV 225 Query: 94 PLRSSWVMTCAYAPSGNYVACGGLDNICSIY 124 + S + +++ + +A D I+ Sbjct: 226 LVAESDIKELSHSGQADSIAVTTEDGSLEIF 256 >3DW8-B nrPDB Length = 447 Score = 62.8 bits (151), Expect = 2e-10, Method: Composition-based stats. Identities = 53/369 (14%), Positives = 105/369 (28%), Gaps = 115/369 (31%) Query: 58 IYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVH-----------AIPLRSS-------- 98 I + + LL + + G+++I+ NK+ Sbjct: 31 ISTVEFNHSGELLATGDKGGRVVIFQQEQENKIQSHSRGEYNVYSTFQSHEPEFDYLKSL 90 Query: 99 ----WVMTCAYAPSGN--YVACGGLDNICSIYNLKTREG--------------------- 131 + + P N D ++ + R+ Sbjct: 91 EIEEKINKIRWLPQKNAAQFLLSTNDKTIKLWKISERDKRPEGYNLKEEDGRYRDPTTVT 150 Query: 132 --------------NVRVSRELA-GHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQ- 175 R A HT +++ D + S+ D LW +E Sbjct: 151 TLRVPVFRPMDLMVEASPRRIFANAHTYHINSISINSDYETYLSADDLRINLWHLEITDR 210 Query: 176 -------QTTTFTGHTGDVMSLSLAPDT-RLFVSGACDASAKLWDVREGMCRQTFTGHES 227 + T + + P++ FV + + +L D+R Sbjct: 211 SFNIVDIKPANMEELTEVITAAEFHPNSCNTFVYSSSKGTIRLCDMR------------- 257 Query: 228 DINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLA 287 A+ D +LF+ D ++ + II I+ V FS SGR ++ Sbjct: 258 --------------ASALCDRHSKLFEEPEDPSNRSFFSE-IISSISDVKFSHSGRYMMT 302 Query: 288 GYDDFNCNVWDAL-KADRAGVLAGHD---NRVSCL------------GVTDDGMAVATGS 331 D + VWD + H+ +++ L V TGS Sbjct: 303 R-DYLSVKVWDLNMENRPVETYQVHEYLRSKLCSLYENDCIFDKFECCWNGSDSVVMTGS 361 Query: 332 WDSFLKIWN 340 +++F ++++ Sbjct: 362 YNNFFRMFD 370 >5WLC-LV nrPDB Length = 707 Score = 59.7 bits (143), Expect = 2e-09, Method: Composition-based stats. Identities = 39/311 (12%), Positives = 89/311 (28%), Gaps = 26/311 (8%) Query: 32 QITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRL-LVSASQDGKLIIWDSYTTNKV 90 Q+ N+++ R+++ + D + + + + ++ ++D + Sbjct: 36 QLKNDLEYQNRVELIQDFEF---SEASNKIKVSRDGQYCMATGTYKPQIHVYDFANLSLK 92 Query: 91 HAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCR 150 + V + D N R+ + + Sbjct: 93 FDRHTDAENVDFTILSDDWTKSVHLQNDRSIQFQNKGGLHYTTRIPK-------FGRSLV 145 Query: 151 FLDDNQ--IVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASA 208 + N V +SG+ L ++E G+ F T V +S+ L +G Sbjct: 146 YNKVNCDLYVGASGNELYRL-NLEKGRFLNPFKLDTEGVNHVSINEVNGLLAAGTETNVV 204 Query: 209 KLWDVREGMCRQTFTGHES------DINAICFFPNGNAFATGSDDATCRLFDLRADQELM 262 + WD R + + F +G FA G+ + ++DLR + Sbjct: 205 EFWDPRSRSRVSKLYLENNIDNRPFQVTTTSFRNDGLTFACGTSNGYSYIYDLRTSEP-S 263 Query: 263 TYSHDNIICGITSVSFSKS---GRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLG 319 I + + + ++ D +WD L + ++ + Sbjct: 264 IIKDQGYGFDIKKIIWLDNVGTENKIVTC-DKRIAKIWDRLDGKAYASMEP-SVDINDIE 321 Query: 320 VTDDGMAVATG 330 T Sbjct: 322 HVPGTGMFFTA 332 >5WLC-LS nrPDB Length = 594 Score = 59.7 bits (143), Expect = 2e-09, Method: Composition-based stats. Identities = 46/345 (13%), Positives = 103/345 (29%), Gaps = 63/345 (18%) Query: 56 AKIYAMHWGTDSRLLVSASQDGKLIIW--DSYTTNKVHAIPLRSSWVMTCAY-----APS 108 + I ++ + LL++ D L I+ D T + V ++ L S + TC + + Sbjct: 249 SAIQSLSFHPSKPLLLTGGYDKTLRIYHIDGKTNHLVTSLHLVGSPIQTCTFYTSLSNQN 308 Query: 109 GNYVACGGLDNICSIYNLK------TREGNVRVSRELAGHTGYLSC-----CRFLDDNQI 157 + G ++L ++ + L GH L ++Q Sbjct: 309 QQNIFTAGRRRYMHSWDLSLENLTHSQTAKIEKFSRLYGHESTQRSFENFKVAHLQNSQT 368 Query: 158 VTSSGDTTCALWDIETGQQTTTFTGHTGDVM-----------SLSLAPDTR-----LFVS 201 + G L G + +M + P +R + ++ Sbjct: 369 NSVHG---IVLLQGNNGWINILHSTSGLWLMGCKIEGVITDFCIDYQPISRGKFRTILIA 425 Query: 202 GACDASAKLWDVR-EGMCRQTFT--------------GHESDINAICFFP--NGNAFATG 244 +D+ G + + G + A+ A G Sbjct: 426 VNAYGEVWEFDLNKNGHVIRRWKDQGGVGITKIQVGGGTTTTCPALQISKIKQNRWLAVG 485 Query: 245 SDDATCRLFD----LRADQELMTYSHDNIICGITSVSFSKSGRLL--LAGYDDFNCNVWD 298 S+ L+D + + + D + I+++ FS G++L + + Sbjct: 486 SESGFVNLYDRNNAMTSSTPTPVAALDQLTTTISNLQFSPDGQILCMASRAVKDALRLVH 545 Query: 299 ALKADRAGVLAGHD---NRVSCLGVTDDGMAVATGSWDSFLKIWN 340 +V+ + + G +A G+ +++W Sbjct: 546 LPSCSVFSNWPTSGTPLGKVTSVAFSPSGGLLAVGNEQGKVRLWK 590 Score = 54.7 bits (130), Expect = 6e-08, Method: Composition-based stats. Identities = 28/203 (13%), Positives = 58/203 (28%), Gaps = 24/203 (11%) Query: 27 DATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYT 86 + ++ + P+ R + RT +++ + + + W Sbjct: 401 EGVITDFCIDYQPISRGKFRTILIAVNAYGEVWEFDLNKNGHV---------IRRWKDQG 451 Query: 87 TNKVHAIPLRSSWVMTC-----AYAPSGNYVACGGLDNICSIYNLKTR--EGNVRVSREL 139 + I + TC + ++A G ++Y+ L Sbjct: 452 GVGITKIQVGGGTTTTCPALQISKIKQNRWLAVGSESGFVNLYDRNNAMTSSTPTPVAAL 511 Query: 140 AGHTGYLSCCRFLDDNQIVTSSGDTTCA----LWDIETGQQ---TTTFTGHTGDVMSLSL 192 T +S +F D QI+ L + + T G V S++ Sbjct: 512 DQLTTTISNLQFSPDGQIL-CMASRAVKDALRLVHLPSCSVFSNWPTSGTPLGKVTSVAF 570 Query: 193 APDTRLFVSGACDASAKLWDVRE 215 +P L G +LW + Sbjct: 571 SPSGGLLAVGNEQGKVRLWKLNH 593 Score = 54.3 bits (129), Expect = 7e-08, Method: Composition-based stats. Identities = 46/316 (14%), Positives = 85/316 (26%), Gaps = 80/316 (25%) Query: 79 LIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRE 138 + + D+ ++ H S + + ++ PS + GG D IY++ + ++ S Sbjct: 236 VRLKDANASHPSH------SAIQSLSFHPSKPLLLTGGYDKTLRIYHIDGKTNHLVTSLH 289 Query: 139 LAGHTGYLSCCRF------LDDNQIVTSSGDTTCALWDIETGQQT----------TTFTG 182 L G + C F + I T+ WD+ T + G Sbjct: 290 LVG--SPIQTCTFYTSLSNQNQQNIFTAGRRRYMHSWDLSLENLTHSQTAKIEKFSRLYG 347 Query: 183 H-------------------TGDVMSLSL----APDTRLFVSGA-------------CDA 206 H T V + L + S + D Sbjct: 348 HESTQRSFENFKVAHLQNSQTNSVHGIVLLQGNNGWINILHSTSGLWLMGCKIEGVITDF 407 Query: 207 SAKLWDVREGMCRQTFTGHES--DINAICFFPNGNAFATGSDDATCRLFDLRAD---QEL 261 + G R + ++ NG R + + ++ Sbjct: 408 CIDYQPISRGKFRTILIAVNAYGEVWEFDLNKNG---------HVIRRWKDQGGVGITKI 458 Query: 262 MTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWD------ALKADRAGVLAGHDNRV 315 C +S K R L G + N++D + L + Sbjct: 459 QVGGGTTTTCPALQISKIKQNRWLAVGSESGFVNLYDRNNAMTSSTPTPVAALDQLTTTI 518 Query: 316 SCLGVTDDGMAVATGS 331 S L + DG + S Sbjct: 519 SNLQFSPDGQILCMAS 534 Score = 51.2 bits (121), Expect = 7e-07, Method: Composition-based stats. Identities = 24/116 (20%), Positives = 36/116 (31%), Gaps = 9/116 (7%) Query: 195 DTRLFVSGACDASAKLWD------VREGMCRQTFTGHESDINAICFFPNGNAFATGSD-- 246 R G+ L+D + I+ + F P+G S Sbjct: 478 QNRWLAVGSESGFVNLYDRNNAMTSSTPTPVAALDQLTTTISNLQFSPDGQILCMASRAV 537 Query: 247 DATCRLFDLRADQELMTYSHDNIICG-ITSVSFSKSGRLLLAGYDDFNCNVWDALK 301 RL L + + G +TSV+FS SG LL G + +W Sbjct: 538 KDALRLVHLPSCSVFSNWPTSGTPLGKVTSVAFSPSGGLLAVGNEQGKVRLWKLNH 593 >5K1H-B nrPDB Length = 576 Score = 58.5 bits (140), Expect = 4e-09, Method: Composition-based stats. Identities = 60/370 (16%), Positives = 117/370 (31%), Gaps = 49/370 (13%) Query: 6 QLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGT 65 + + A + +R + K AT Q I G + + + H + + + Sbjct: 159 SIEERARWTETYVRWSPKGTYLATFHQ--RGIALWGGEKFKQIQRFS-HQG-VQLIDFSP 214 Query: 66 DSRLLVSAS------QD-GKLIIWDSYTTNKVHAIPLRSSWVMTC-AYAPSGNYVACGGL 117 R LV+ S D +IIWD T +K SS ++ G + A L Sbjct: 215 CERYLVTFSPLMDTQDDPQAIIIWDILTGHKKRGFHCESSAHWPIFKWSHDGKFFARMTL 274 Query: 118 DNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIV--TSSGDT----TCALWDI 171 D SIY + + S +++G + + I+ D L + Sbjct: 275 D-TLSIYETPSMGLLDKKSLKISG----IKDFSWSPGGNIIAFWVPEDKDIPARVTLMQL 329 Query: 172 ETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAK----------LWDVREGMCRQT 221 + Q+ L + D + K ++ +RE Sbjct: 330 PSRQEIRVRNLFNVVDCKLHWQKNGDYLCV-KVDRTPKGTQGVVTNFEIFRMREKQVPVD 388 Query: 222 FTGHESDINAICFFPNGNAFATGSDDA---TCRLFDLRADQELMTYSHDNIICGITSVSF 278 + I A + PNG+ FA +A + + ++++ ++ S ++ + Sbjct: 389 VVEMKETIIAFAWEPNGSKFAVLHGEAPRISVSFYHVKSNGKIE-LSKMFDKQQANTIFW 447 Query: 279 SKSGRLLLAG---YDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATG-SW-- 332 S G+ ++ + D + + S + G V T SW Sbjct: 448 SPQGQFVVLAGLRSMNGALAFVDTSDCTVMNIAEHYM--ASDVEWDPTGRYVVTSVSWWS 505 Query: 333 ---DSFLKIW 339 D+ +W Sbjct: 506 HKVDNAYWLW 515 Score = 53.5 bits (127), Expect = 1e-07, Method: Composition-based stats. Identities = 43/222 (19%), Positives = 75/222 (33%), Gaps = 22/222 (9%) Query: 76 DGKLII---WDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGN 132 D + I WD + W+ + + G D +N ++ Sbjct: 101 DKYMTISDEWDIPEKQPFKDLGNLRYWLEEAECRDQYSVIFESG-DRTSIFWN-DVKDPV 158 Query: 133 VRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSL 192 R T R+ + + ALW E +Q F+ H G V + Sbjct: 159 SIEERARWTETY----VRWSPKGTYLATFHQRGIALWGGEKFKQIQRFS-HQG-VQLIDF 212 Query: 193 APDTRLFVSGA------CD-ASAKLWDVREGMCRQTFTGHESDINAI-CFFPNGNAFATG 244 +P R V+ + D + +WD+ G ++ F S I + +G FA Sbjct: 213 SPCERYLVTFSPLMDTQDDPQAIIIWDILTGHKKRGFHCESSAHWPIFKWSHDGKFFARM 272 Query: 245 SDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLL 286 + D T +++ + L S I GI S+S G ++ Sbjct: 273 TLD-TLSIYETPSMGLLDKKSLK--ISGIKDFSWSPGGNIIA 311 >2VDU-B nrPDB Length = 450 Score = 58.2 bits (139), Expect = 5e-09, Method: Composition-based stats. Identities = 31/176 (17%), Positives = 54/176 (30%), Gaps = 11/176 (6%) Query: 58 IYAMHWGTDSRLLVSASQ-DGKLIIWDSYTTNK----VHAIPLRSSWVMTCAYAPSGNYV 112 I + +D L++ + D L+++D T+K + S + A V Sbjct: 105 IRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTV 164 Query: 113 ACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQ----IVTSSGDTTCAL 168 ++ + + GH L+ + D+ I+TS D + Sbjct: 165 IIADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKI 224 Query: 169 WDIETGQQTTT-FTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFT 223 GH V S+ L +S D WD + G TF Sbjct: 225 SHYPQCFIVDKWLFGHKHFVSSIC-CGKDYLLLSAGGDDKIFAWDWKTGKNLSTFD 279 Score = 50.8 bits (120), Expect = 8e-07, Method: Composition-based stats. Identities = 23/178 (12%), Positives = 60/178 (33%), Gaps = 14/178 (7%) Query: 106 APSGNYVACGGLDNICSIYNLK-TREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDT 164 + +AC D ++++ T + +++ + + DD ++ + Sbjct: 112 SDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTVIIADKFG 171 Query: 165 TCALWDIETGQQTTT----FTGHTGDVMSLSL---APDTRLFVSGACDASAKLWDVREGM 217 DI + + GH + + L + + ++ D K+ Sbjct: 172 DVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKI--SHYPQ 229 Query: 218 CRQT---FTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICG 272 C GH+ +++IC + D +D + + L T+ ++++I Sbjct: 230 CFIVDKWLFGHKHFVSSIC-CGKDYLLLSAGGDDKIFAWDWKTGKNLSTFDYNSLIKP 286 Score = 47.8 bits (112), Expect = 7e-06, Method: Composition-based stats. Identities = 30/173 (17%), Positives = 57/173 (32%), Gaps = 29/173 (16%) Query: 24 ACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWD 83 ACAD+ S + ++D + ++ R+ + + A D +II D Sbjct: 119 ACADSDKSLLVFDVDKTSKNVLKLRKRF----------CFSKRPNAISIAEDDTTVIIAD 168 Query: 84 SY----------------TTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLK 127 + T + + V + ++ D I Sbjct: 169 KFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKI---S 225 Query: 128 TREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTF 180 V + L GH ++S D ++++ GD WD +TG+ +TF Sbjct: 226 HYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGGDDKIFAWDWKTGKNLSTF 278 Score = 34.3 bits (77), Expect = 0.089, Method: Composition-based stats. Identities = 15/47 (31%), Positives = 21/47 (44%), Gaps = 1/47 (2%) Query: 51 LRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRS 97 L GH + ++ G D LL+SA D K+ WD T + S Sbjct: 237 LFGHKHFVSSICCGKD-YLLLSAGGDDKIFAWDWKTGKNLSTFDYNS 282 >5WLC-LH nrPDB Length = 896 Score = 55.5 bits (132), Expect = 3e-08, Method: Composition-based stats. Identities = 51/348 (14%), Positives = 92/348 (26%), Gaps = 69/348 (19%) Query: 49 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPS 108 R L+ H+ + ++ + D L+S + + +W T ++ L + P Sbjct: 291 RLLKWHIDSVLSLSFSHDGSYLLSGGWEKVMSLWQLETNSQQFLPRLNGIIIDCQVLGPQ 350 Query: 109 GNYVA--------CGGLDNICSIYN-------LKTREGNVRVSRELAGHTGYLSCCRFLD 153 GNY + D + N L + + +S + Sbjct: 351 GNYYSLILQMTENNSNSDYQFLLLNASDLTSKLSINGPLPVFNSTIKHIQQPISAMNTKN 410 Query: 154 DNQIVT---SSGDTTCALW-----DIETGQQTTTFTG-----HTGDVMSLSL---APDTR 197 N I + S + L D T + H V Sbjct: 411 SNSITSLNHSKKKQSRKLIKSRRQDFTTNVEINPINKNLYFPHISAVQIFDFYKNEQVNY 470 Query: 198 LFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFAT-----------GSD 246 +++ + S G R + I + F +G T S Sbjct: 471 QYLTSGVNNS-------MGKVRFELNLQDPIITDLKFTKDGQWMITYEIEYPPNDLLSSK 523 Query: 247 D--ATCRLF---DLRADQELMT--YSHDNIICGITSVSFSK----SGRLLLAGYDDFNCN 295 D + + D + L T + I IT + S + + L ++ Sbjct: 524 DLTHILKFWTKNDNETNWNLKTKVINPHGISVPITKILPSPRSVNNSQGCLTADNNGGLK 583 Query: 296 VWD--------ALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSF 335 W LK H + L + DG + G D Sbjct: 584 FWSFDSHESNWCLKKISLPNFN-HFSNSVSLAWSQDGSLIFHGFDDKL 630 Score = 45.8 bits (107), Expect = 3e-05, Method: Composition-based stats. Identities = 14/68 (20%), Positives = 31/68 (45%), Gaps = 1/68 (1%) Query: 273 ITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSW 332 ++S++ G+ L G+ ++ L + +L H + V L + DG + +G W Sbjct: 259 VSSMAIDNMGQQLAVGFASGVISIVS-LADLQIRLLKWHIDSVLSLSFSHDGSYLLSGGW 317 Query: 333 DSFLKIWN 340 + + +W Sbjct: 318 EKVMSLWQ 325 Score = 44.7 bits (104), Expect = 6e-05, Method: Composition-based stats. Identities = 12/86 (13%), Positives = 33/86 (38%), Gaps = 1/86 (1%) Query: 175 QQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICF 234 QT + + +T V S+++ + G + + + + H + ++ F Sbjct: 247 SQTQSLSYNTRYVSSMAIDNMGQQLAVGFASGVISIVSLADLQ-IRLLKWHIDSVLSLSF 305 Query: 235 FPNGNAFATGSDDATCRLFDLRADQE 260 +G+ +G + L+ L + + Sbjct: 306 SHDGSYLLSGGWEKVMSLWQLETNSQ 331 Score = 42.4 bits (98), Expect = 3e-04, Method: Composition-based stats. Identities = 16/91 (17%), Positives = 38/91 (41%), Gaps = 1/91 (1%) Query: 39 PVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSS 98 P+G I ++L + + +M + L G + I + + Sbjct: 240 PLGSILSSQTQSLSYNTRYVSSMAIDNMGQQLAVGFASGVISIVSLADLQ-IRLLKWHID 298 Query: 99 WVMTCAYAPSGNYVACGGLDNICSIYNLKTR 129 V++ +++ G+Y+ GG + + S++ L+T Sbjct: 299 SVLSLSFSHDGSYLLSGGWEKVMSLWQLETN 329 Score = 38.9 bits (89), Expect = 0.003, Method: Composition-based stats. Identities = 37/375 (9%), Positives = 104/375 (27%), Gaps = 79/375 (21%) Query: 18 IRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSR----LLVSA 73 + ++K + + + I + H++ + + + + L S Sbjct: 417 LNHSKKKQSRKLIKSRRQDFTTNVEINPINKNLYFPHISAVQIFDFYKNEQVNYQYLTSG 476 Query: 74 SQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNY-------------VACGGLDNI 120 ++ + L+ + + G + ++ L +I Sbjct: 477 --------VNNSMGKVRFELNLQDPIITDLKFTKDGQWMITYEIEYPPNDLLSSKDLTHI 528 Query: 121 CSIYNLKTREGNVRV-SRELAGHTGYLSCCRFLDDNQI-------VTSSGDTTCALWDIE 172 + E N + ++ + H + + L + +T+ + W + Sbjct: 529 LKFWTKNDNETNWNLKTKVINPHGISVPITKILPSPRSVNNSQGCLTADNNGGLKFWSFD 588 Query: 173 TGQQTTTFTG-------HTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGH 225 + + H + +SL+ + D L G D ++ D ++ Sbjct: 589 SHESNWCLKKISLPNFNHFSNSVSLAWSQDGSLIFHG-FDDKLQILDFDTFKKFESLENT 647 Query: 226 E--------SDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVS 277 + S+I + + N T +L Q + ++ + G+ Sbjct: 648 KTVSEFTLDSEIQTVKLINDTNLIVATRT--TLNAINLLRGQVINSFDLYPFVNGVYK-- 703 Query: 278 FSKSGRLLLAGYD------------------------DFNCNVWDALKADRAGVLAGHDN 313 + L+ + ++D+ + + G H+ Sbjct: 704 -NGHMDRLITCDERTGNIALVINQQLTDLDGVPTINYKSRIIIFDSDLSTKLGNFTHHE- 761 Query: 314 RVSCLGVTDDGMAVA 328 +S +G D + Sbjct: 762 YISWIGWNYDTDFIF 776 Score = 37.7 bits (86), Expect = 0.008, Method: Composition-based stats. Identities = 17/82 (20%), Positives = 32/82 (39%), Gaps = 3/82 (3%) Query: 220 QTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFS 279 Q+ + + ++++ G A G + L Q + H I + S+SFS Sbjct: 250 QSLSYNTRYVSSMAIDNMGQQLAVGFASGVISIVSLADLQIRLLKWH---IDSVLSLSFS 306 Query: 280 KSGRLLLAGYDDFNCNVWDALK 301 G LL+G + ++W Sbjct: 307 HDGSYLLSGGWEKVMSLWQLET 328 >6CVZ-A nrPDB Length = 351 Score = 55.1 bits (131), Expect = 5e-08, Method: Composition-based stats. Identities = 28/158 (17%), Positives = 54/158 (34%), Gaps = 22/158 (13%) Query: 130 EGNVRVSRELAGHTGYLSCCRFLDD--NQIVTSSGDTTCALWDIETGQQTTTFTGHTGDV 187 N++ S+ + H + F ++++S D T L +ET T+ V Sbjct: 61 TANMKSSQYIPMHGKQIRGLAFSSYLRGLLLSASLDNTIKLTSLETNTVVQTYNA-GRPV 119 Query: 188 MSLSLAPDT-RLFVSGACDASAKLWDVR-EGMCRQTFTGHESDINAICFF---------- 235 S D +G + S ++DVR Q ++ + Sbjct: 120 WSCCWCLDEANYIYAGLANGSILVYDVRNTSSHVQELVAQKARCPLVSLSYMPRAASAAF 179 Query: 236 PNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGI 273 P G A +DA+ ++ + M +SH + + Sbjct: 180 PYGGVLAGTLEDAS--FWE-----QKMDFSHWPHVLPL 210 Score = 49.3 bits (116), Expect = 2e-06, Method: Composition-based stats. Identities = 50/300 (16%), Positives = 99/300 (33%), Gaps = 42/300 (14%) Query: 37 IDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSR-LLVSASQDGKLIIWDSYTTNKVHAIPL 95 + + M++ + + H +I + + + R LL+SAS D + + T V Sbjct: 56 VKMLSTANMKSSQYIPMHGKQIRGLAFSSYLRGLLLSASLDNTIKLTSLETNTVVQTYNA 115 Query: 96 RSSWVMTCAY-APSGNYVACGGLDNICSIYNLKTREGNV--------RVSRELAGHTGYL 146 V +C + NY+ G + +Y+++ +V R + Sbjct: 116 -GRPVWSCCWCLDEANYIYAGLANGSILVYDVRNTSSHVQELVAQKARCPLVSLSYMPRA 174 Query: 147 SCCRFLDDNQIVTSSGDTTCALWD-------------IETGQQTTTFTGHTGDVMSLSLA 193 + F + + D + W+ +E G T ++ ++ Sbjct: 175 ASAAFPYGGVLAGTLEDASF--WEQKMDFSHWPHVLPLEPGGCIDFQTENSSRHCLVTYR 232 Query: 194 PDTRL--FVSGACDASAKLWDVREGMC----RQTFTGHES----DINAICFFP--NGNAF 241 PD S + S +L D +C TF G + NAI P +GN Sbjct: 233 PDKNHTTIRSVLMEMSYRLDDTGNPICSCQPVHTFFGGPTCKLLTKNAIFQSPENDGNIL 292 Query: 242 ATGSDD--ATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDF-NCNVWD 298 D+ + L+D + L D + I +++ L + + W+ Sbjct: 293 VCTGDEAANSALLWDAASGSLLQDLQTDQPVLDICPFEVNRNS-YLATLTEKMVHIYKWE 351 Score = 30.8 bits (68), Expect = 0.79, Method: Composition-based stats. Identities = 7/69 (10%), Positives = 23/69 (33%), Gaps = 2/69 (2%) Query: 271 CGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGM-AVAT 329 ++ + S+ + F + + + H ++ L + + + Sbjct: 34 DALSCLVISQPSPQ-ASFLPGFGVKMLSTANMKSSQYIPMHGKQIRGLAFSSYLRGLLLS 92 Query: 330 GSWDSFLKI 338 S D+ +K+ Sbjct: 93 ASLDNTIKL 101 >4AV8-A nrPDB Length = 339 Score = 51.6 bits (122), Expect = 4e-07, Method: Composition-based stats. Identities = 41/258 (15%), Positives = 79/258 (30%), Gaps = 24/258 (9%) Query: 52 RGH-LAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRS-SWVMTCAYAPSG 109 H I + D L+ + +D Y + + I + T Sbjct: 10 ENHVSNPIVDYEFNQDQSCLIVS----TPKSFDIYNVHPLKRIMSQEMPDAGTIRMLHRT 65 Query: 110 NYVA-CGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCAL 168 NY+A + I++ ++ RV + + FL IV S GD ++ Sbjct: 66 NYIAFVSTKKELLHIWDDVKKQDITRVKLD-----AAVKDL-FLSREFIVVSQGDV-ISI 118 Query: 169 WDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACD-ASAKLWDVREGMCRQT-----F 222 + T G V + + L S + + ++ + Sbjct: 119 FKFGNPWNKITEDIKFGGVCEFA---NGLLVYSNEFNLGQIHVTRLQTDAEQVVGKGVLV 175 Query: 223 TGHESDINAICFFPNGNAFATGSDDAT-CRLFDLRADQELMTYSHDNIICGITSVSFSKS 281 H + + + G+ AT S D T R+F + + I + +S Sbjct: 176 KAHANPVKMVRLNRKGDMVATCSQDGTLIRVFQTDNGVLVREFRRGLDRTSIIDMRWSPD 235 Query: 282 GRLLLAGYDDFNCNVWDA 299 G L D + +V++ Sbjct: 236 GSKLAVVSDKWTLHVFEV 253 Score = 50.8 bits (120), Expect = 8e-07, Method: Composition-based stats. Identities = 17/93 (18%), Positives = 36/93 (38%), Gaps = 3/93 (3%) Query: 181 TGHTGDVMSLSLAPDTRLFVSGACDAS-AKLWDVREGMCRQTFTGHES--DINAICFFPN 237 H V + L + + + D + +++ G+ + F I + + P+ Sbjct: 176 KAHANPVKMVRLNRKGDMVATCSQDGTLIRVFQTDNGVLVREFRRGLDRTSIIDMRWSPD 235 Query: 238 GNAFATGSDDATCRLFDLRADQELMTYSHDNII 270 G+ A SD T +F++ D E + + I Sbjct: 236 GSKLAVVSDKWTLHVFEVFNDAENKRHVLKDWI 268 Score = 49.7 bits (117), Expect = 2e-06, Method: Composition-based stats. Identities = 22/152 (14%), Positives = 53/152 (34%), Gaps = 4/152 (2%) Query: 52 RGHLAKIYAMHWGTDSRLLVSASQDGK-LIIWDSYTTNKVHAIP--LRSSWVMTCAYAPS 108 + H + + ++ + SQDG + ++ + V L + ++ ++P Sbjct: 176 KAHANPVKMVRLNRKGDMVATCSQDGTLIRVFQTDNGVLVREFRRGLDRTSIIDMRWSPD 235 Query: 109 GNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCAL 168 G+ +A ++ + N R + + Y + + ++ S G C + Sbjct: 236 GSKLAVVSDKWTLHVFEVFNDAENKRHVLKDWINIKYFQSEWSICNFKLKVSKGSNDCKI 295 Query: 169 -WDIETGQQTTTFTGHTGDVMSLSLAPDTRLF 199 W +TG D L+ D ++ Sbjct: 296 AWISDTGLVIVWPNRRLADTFKLNYNDDEHVW 327 Score = 32.7 bits (73), Expect = 0.25, Method: Composition-based stats. Identities = 25/208 (12%), Positives = 61/208 (29%), Gaps = 23/208 (11%) Query: 143 TGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSG 202 + + F D + S + ++++ ++ + + + L + Sbjct: 14 SNPIVDYEFNQDQSCLIVSTPKSFDIYNVHPLKRIMSQEMPDAGTIRM-LHRTNYIAFVS 72 Query: 203 ACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELM 262 +WD + T ++ + + F + D +F + Sbjct: 73 TKKELLHIWDDVKKQDI-TRVKLDAAVKDL-FLSREFIVVSQGD--VISIFKFGNPWNKI 128 Query: 263 TYS-HDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGV--------LAGHDN 313 T +C +G L+ ++FN + + H N Sbjct: 129 TEDIKFGGVCEF------ANGLLVY--SNEFNLGQIHVTRLQTDAEQVVGKGVLVKAHAN 180 Query: 314 RVSCLGVTDDGMAVATGSWDSF-LKIWN 340 V + + G VAT S D ++++ Sbjct: 181 PVKMVRLNRKGDMVATCSQDGTLIRVFQ 208 Score = 32.0 bits (71), Expect = 0.43, Method: Composition-based stats. Identities = 9/67 (13%), Positives = 20/67 (29%), Gaps = 3/67 (4%) Query: 269 IICGITSVSFSKSGRLLLAGYDDFN-CNVWDALKADRAGVLAGHDNR--VSCLGVTDDGM 325 + V ++ G ++ D V+ +R + + + DG Sbjct: 178 HANPVKMVRLNRKGDMVATCSQDGTLIRVFQTDNGVLVREFRRGLDRTSIIDMRWSPDGS 237 Query: 326 AVATGSW 332 +A S Sbjct: 238 KLAVVSD 244 >6N8P-A nrPDB Length = 979 Score = 51.2 bits (121), Expect = 7e-07, Method: Composition-based stats. Identities = 42/254 (16%), Positives = 76/254 (29%), Gaps = 46/254 (18%) Query: 83 DSYTTNKV--HAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELA 140 D + NK H P + S Y+PS +A G +Y E L Sbjct: 8 DLFQFNKTVEHGFPHQPS---ALGYSPSLRILAIGTRSGAIKLYGAPGVE-----FMGLH 59 Query: 141 GHTGYLSCCRFLDDN-QIVTSSGDTTCALWDIETG--------QQTTTFTGHTG------ 185 ++ L Q+VT D + LW ++ ++ T G G Sbjct: 60 QENNAVTQIHLLPGQCQLVTLLDDNSLHLWSLKVKGGASELQEDESFTLRGPPGAAPSAT 119 Query: 186 DVMSLSLAPDTRLFVSGACDASAKLWDV-----------REGMCRQTFTG---HESD--- 228 + + L G + + + Q H Sbjct: 120 QITVVLPHSSCELLYLGTESGNVFVVQLPAFRALEDRTISSDAVLQRLPEEARHRRVFEM 179 Query: 229 INAICFFP-NGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLA 287 + A+ P + N G ++DL+ + L H + ++ + + GRLL++ Sbjct: 180 VEALQEHPRDPNQILIGYSRGLVVIWDLQGSRVLY---HFLSSQQLENIWWQRDGRLLVS 236 Query: 288 GYDDFNCNVWDALK 301 + D + W Sbjct: 237 CHSDGSYCQWPVSS 250 Score = 43.9 bits (102), Expect = 9e-05, Method: Composition-based stats. Identities = 58/324 (17%), Positives = 97/324 (29%), Gaps = 72/324 (22%) Query: 17 QIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGT-DSRLLVSASQ 75 + + R +DA L ++ + R RR + A+ D ++ Sbjct: 151 RALEDRTISSDAVLQRLPE--------EARHRRVFE----MVEALQEHPRDPNQILIGYS 198 Query: 76 DGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRV 135 G ++IWD + ++ L S + + G + D + + + Sbjct: 199 RGLVVIWDLQGSRVLYHF-LSSQQLENIWWQRDGRLLVSCHSDGSYCQWPVSSEAQQPEP 257 Query: 136 SRELAGHTGYLSCCRFLDDNQIVT----------------SSGDTTC--ALWDIETGQQT 177 R L + G C + T S GD C + D GQQT Sbjct: 258 LRSLVPY-GPFPCKAITRILWLTTRQGLPFTIFQGGMPRASYGDRHCISVIHD---GQQT 313 Query: 178 TTFTGHTGDVMSLSL---------APDTRLFVSGACDASAKLWDVREGMCRQT-----FT 223 T V+ ++ D V A + + D++ + Sbjct: 314 AFDF--TSRVIGFTVLTEADPAATFDDPYALVVLAEEELVVI-DLQTAGWPPVQLPYLAS 370 Query: 224 GHESDINAICFFPN------GNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVS 277 H S I N A GS R + T + I G TS++ Sbjct: 371 LHCSAITCSHHVSNIPLKLWERIIAAGS----------RQNAHFSTM--EWPIDGGTSLT 418 Query: 278 FS-KSGRLLLAGYDDFNCNVWDAL 300 + LLL G++D WDA Sbjct: 419 PAPPQRDLLLTGHEDGTVRFWDAS 442 Score = 41.2 bits (95), Expect = 7e-04, Method: Composition-based stats. Identities = 45/381 (11%), Positives = 90/381 (23%), Gaps = 97/381 (25%) Query: 55 LAKIYAMHWGTDSRLLVSASQDGKLIIWDSY--------TTNKVHAIPLRSSW------V 100 + +H LV+ D L +W ++ + + Sbjct: 62 NNAVTQIHLLPGQCQLVTLLDDNSLHLWSLKVKGGASELQEDESFTLRGPPGAAPSATQI 121 Query: 101 MTCAYAPSGNYVACGGLDNICSIYNLK----------TREGNVRVSRELAGHTGYLSCCR 150 S + G + L + + ++ E A H Sbjct: 122 TVVLPHSSCELLYLGTESGNVFVVQLPAFRALEDRTISSDAVLQRLPEEARHRRVFEMVE 181 Query: 151 FL-----DDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACD 205 L D NQI+ +WD++ + F + + ++ D RL VS D Sbjct: 182 ALQEHPRDPNQILIGYSRGLVVIWDLQGSRVLYHFLS-SQQLENIWWQRDGRLLVSCHSD 240 Query: 206 ASAKLWDVRE----GMCRQTFTGHE----SDINAICF-------------------FPNG 238 S W V ++ + I I + Sbjct: 241 GSYCQWPVSSEAQQPEPLRSLVPYGPFPCKAITRILWLTTRQGLPFTIFQGGMPRASYGD 300 Query: 239 NAFATGSDDATCRLFDLRA---------------------------DQELMTYSHDNIIC 271 + D FD + ++EL+ Sbjct: 301 RHCISVIHDGQQTAFDFTSRVIGFTVLTEADPAATFDDPYALVVLAEEELVVIDLQTAGW 360 Query: 272 GITSVSF--SKSGRLLLAGYDDFNC--NVWDALKADRAGVLAGHDNRV-------SCLGV 320 + + S + + N +W+ H + + + L Sbjct: 361 PPVQLPYLASLHCSAITCSHHVSNIPLKLWE-RIIAAGSRQNAHFSTMEWPIDGGTSLTP 419 Query: 321 TD-DGMAVATGSWDSFLKIWN 340 + TG D ++ W+ Sbjct: 420 APPQRDLLLTGHEDGTVRFWD 440 Score = 34.7 bits (78), Expect = 0.069, Method: Composition-based stats. Identities = 16/79 (20%), Positives = 32/79 (40%), Gaps = 2/79 (2%) Query: 262 MTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVT 321 T H +++ +S S R+L G ++ A + G L +N V+ + + Sbjct: 14 KTVEH-GFPHQPSALGYSPSLRILAIGTRSGAIKLYGAPGVEFMG-LHQENNAVTQIHLL 71 Query: 322 DDGMAVATGSWDSFLKIWN 340 + T D+ L +W+ Sbjct: 72 PGQCQLVTLLDDNSLHLWS 90 Score = 32.7 bits (73), Expect = 0.25, Method: Composition-based stats. Identities = 13/55 (23%), Positives = 23/55 (41%), Gaps = 3/55 (5%) Query: 194 PDTRLFVSGACDASAKLWDVREGMCRQ-TFTGHESDINAICFFPNGNAFATGSDD 247 P L ++G D + + WD G+C + + + PN N F+ +D Sbjct: 422 PQRDLLLTGHEDGTVRFWDA-SGVCLRLLYKLSTVRVFLTDTDPNEN-FSAQGED 474 Score = 30.8 bits (68), Expect = 0.83, Method: Composition-based stats. Identities = 11/60 (18%), Positives = 23/60 (38%), Gaps = 2/60 (3%) Query: 35 NNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSR-LLVSASQDGKLIIWDSYTTNKVHAI 93 I G Q T+ + ++ R LL++ +DG + WD+ + + + Sbjct: 391 ERIIAAGSRQNAHFSTMEWPIDGGTSLTPAPPQRDLLLTGHEDGTVRFWDA-SGVCLRLL 449 >4YHC-A nrPDB Length = 468 Score = 46.6 bits (109), Expect = 1e-05, Method: Composition-based stats. Identities = 15/90 (16%), Positives = 31/90 (34%), Gaps = 1/90 (1%) Query: 224 GHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGR 283 H+ DI I N FA+ D + ++DLR + S + + + +++ G Sbjct: 28 HHQLDILKIAVSENYKTFASVGLDRSLVVWDLRQWCTKLVLSKEQMPRTLKAIALDPQGN 87 Query: 284 LLLAGYDDFNCNVWDALKADRAGVLAGHDN 313 + D + + + H Sbjct: 88 YVSLFSKD-TLFILNVESPSLMLQHSYHSK 116 Score = 45.1 bits (105), Expect = 5e-05, Method: Composition-based stats. Identities = 19/100 (19%), Positives = 46/100 (46%), Gaps = 3/100 (3%) Query: 183 HTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESD--INAICFFPNGNA 240 H D++ ++++ + + F S D S +WD+R+ + + + + AI P GN Sbjct: 29 HQLDILKIAVSENYKTFASVGLDRSLVVWDLRQWCTKLVLSKEQMPRTLKAIALDPQGNY 88 Query: 241 FATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSK 280 + S D T + ++ + ++ +S+ + +V + Sbjct: 89 VSLFSKD-TLFILNVESPSLMLQHSYHSKPNSKLNVFWMP 127 Score = 37.7 bits (86), Expect = 0.008, Method: Composition-based stats. Identities = 24/113 (21%), Positives = 38/113 (33%), Gaps = 13/113 (11%) Query: 19 RDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGK 78 D + D TL + I+PV H I + + + S D Sbjct: 4 SDHDELSTDTTLHEEKFRIEPVPVH----------HQLDILKIAVSENYKTFASVGLDRS 53 Query: 79 LIIWDSYTT--NKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTR 129 L++WD V + + A P GNYV+ D I N+++ Sbjct: 54 LVVWDLRQWCTKLVLSKEQMPRTLKAIALDPQGNYVSLFSKD-TLFILNVESP 105 Score = 31.2 bits (69), Expect = 0.65, Method: Composition-based stats. Identities = 12/107 (11%), Positives = 28/107 (26%), Gaps = 4/107 (3%) Query: 125 NLKTREGNVRVSRELAGHT-GYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGH 183 + E R+ H L + + D + +WD+ + Sbjct: 12 DTTLHEEKFRIEPVPVHHQLDILKIAVSENYKTFASVGLDRSLVVWDLRQWCTKLVLSKE 71 Query: 184 TGDVM--SLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESD 228 +++L P + D + + +V + H Sbjct: 72 QMPRTLKAIALDPQGNYVSLFSKD-TLFILNVESPSLMLQHSYHSKP 117 Score = 28.5 bits (62), Expect = 4.8, Method: Composition-based stats. Identities = 11/65 (16%), Positives = 21/65 (32%), Gaps = 7/65 (10%) Query: 276 VSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSF 335 + +S L D K V H + + V+++ A+ D Sbjct: 1 MGWSDHDEL----STDTTL---HEEKFRIEPVPVHHQLDILKIAVSENYKTFASVGLDRS 53 Query: 336 LKIWN 340 L +W+ Sbjct: 54 LVVWD 58 >4NOX-A nrPDB Length = 746 Score = 46.2 bits (108), Expect = 2e-05, Method: Composition-based stats. Identities = 24/191 (12%), Positives = 48/191 (25%), Gaps = 33/191 (17%) Query: 162 GDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQT 221 GDT W+ E Q + +P S +LW + Sbjct: 176 GDTVGVFWNNEKDQPENIVDRQHWTETFVQWSPLGTYLTSVHAQG-VQLWGGASWSRLRR 234 Query: 222 FTGHESDINAICFFPNGNAFATGS-----------------DDA-TCRLFDLRADQELMT 263 F +N + F P T S DD ++D+ + L + Sbjct: 235 FPH--PFVNLVAFSPGEKYLVTWSNRPIQIPDSGHPVLTLDDDGKNYIIWDIETARPLRS 292 Query: 264 YSHDN------------IICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGH 311 ++ + +S + + + ++++ K + A Sbjct: 293 FAQQDIHPEEHGPKKGPPKFPWPVFKWSADDKYVARLNQGTSISIYELPKMNLLDKQAVK 352 Query: 312 DNRVSCLGVTD 322 V Sbjct: 353 IEGVMDFEWAP 363 Score = 32.0 bits (71), Expect = 0.40, Method: Composition-based stats. Identities = 23/91 (25%), Positives = 28/91 (30%), Gaps = 20/91 (21%) Query: 213 VREGMCRQTFTGHESDINAICFFPNGNAFA------TGSDDATCRLFDLRADQELMTYSH 266 V +T NAI + P G T S D +DL D E Sbjct: 510 VGSFKHLRTLEKKNH--NAIYWSPKGRFVVIATVHNTQSSD--LEFWDLDFDGEKPENEK 565 Query: 267 DNIIC----------GITSVSFSKSGRLLLA 287 D C GIT V + SGR + Sbjct: 566 DLAACLQLMGTGDHYGITDVEWDPSGRYVAT 596 >4FHN-A nrPDB Length = 394 Score = 45.8 bits (107), Expect = 3e-05, Method: Composition-based stats. Identities = 21/111 (18%), Positives = 37/111 (33%), Gaps = 9/111 (8%) Query: 52 RGHLAKIYAMH----WGTDSR----LLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTC 103 GH + + + D+R ++ S D LIIW + A SS ++ Sbjct: 134 SGHHNFVNDIDIADVYSADNRLAEQVIASVGDDCTLIIWRLTDEGPILAGYPLSSPGISV 193 Query: 104 AYAPSG-NYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLD 153 + PS N + G + I++ S+ +L L Sbjct: 194 QFRPSNPNQLIVGERNGNIRIFDWTLNLSAEENSQTELVKNPWLLTLNTLP 244 Score = 42.0 bits (97), Expect = 4e-04, Method: Composition-based stats. Identities = 27/195 (13%), Positives = 60/195 (30%), Gaps = 24/195 (12%) Query: 82 WDSYTTNKVHAIP-LRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELA 140 W S + + + + + + + + G + ++ ++T + +S + Sbjct: 24 WCSQSPSCSNLLAIGHDTGITIYCASEEQTPGSTGLT--LQELFTIQTGLPTLHLSFSSS 81 Query: 141 G------HTGYLSCCRFLDDNQIVTS-SGDTTCALWDIETGQQTTTF-----TGHTGDVM 188 H G + + + D T L + T +GH V Sbjct: 82 CSYSENLHDGDGNVNSSPVYSLFLACVCQDNTVRLIITKNETIITQHVLGGKSGHHNFVN 141 Query: 189 SLSLAPD--------TRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFP-NGN 239 + +A ++ S D + +W + + S ++ F P N N Sbjct: 142 DIDIADVYSADNRLAEQVIASVGDDCTLIIWRLTDEGPILAGYPLSSPGISVQFRPSNPN 201 Query: 240 AFATGSDDATCRLFD 254 G + R+FD Sbjct: 202 QLIVGERNGNIRIFD 216 Score = 40.8 bits (94), Expect = 9e-04, Method: Composition-based stats. Identities = 22/130 (16%), Positives = 41/130 (31%), Gaps = 23/130 (17%) Query: 184 TGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCR--QTF---TGHESDINAIC----F 234 + V SL D + +L + +GH + +N I + Sbjct: 97 SSPVYSL-------FLACVCQDNTVRLIITKNETIITQHVLGGKSGHHNFVNDIDIADVY 149 Query: 235 FPNGNA----FATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSG-RLLLAGY 289 + A+ DD T ++ L + + + SV F S L+ G Sbjct: 150 SADNRLAEQVIASVGDDCTLIIWRLTDEGP--ILAGYPLSSPGISVQFRPSNPNQLIVGE 207 Query: 290 DDFNCNVWDA 299 + N ++D Sbjct: 208 RNGNIRIFDW 217 >5GRS-A nrPDB Length = 396 Score = 44.7 bits (104), Expect = 6e-05, Method: Composition-based stats. Identities = 15/88 (17%), Positives = 30/88 (34%), Gaps = 1/88 (1%) Query: 224 GHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGR 283 H+ DI I N FA+ D ++DLR + S + + + +++ G Sbjct: 28 HHQLDILKIAVSENYKTFASVGLDRCLVVWDLRQWCTKLVLSKEQMPRTLKAIALDPQGN 87 Query: 284 LLLAGYDDFNCNVWDALKADRAGVLAGH 311 + D + + + H Sbjct: 88 YVSLFSKD-TLFILNVESPSLMLQHSYH 114 Score = 42.8 bits (99), Expect = 2e-04, Method: Composition-based stats. Identities = 18/100 (18%), Positives = 44/100 (44%), Gaps = 3/100 (3%) Query: 183 HTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESD--INAICFFPNGNA 240 H D++ ++++ + + F S D +WD+R+ + + + + AI P GN Sbjct: 29 HQLDILKIAVSENYKTFASVGLDRCLVVWDLRQWCTKLVLSKEQMPRTLKAIALDPQGNY 88 Query: 241 FATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSK 280 + S D T + ++ + ++ +S+ +V + Sbjct: 89 VSLFSKD-TLFILNVESPSLMLQHSYHCKPNSKLNVFWMP 127 Score = 38.1 bits (87), Expect = 0.006, Method: Composition-based stats. Identities = 24/113 (21%), Positives = 38/113 (33%), Gaps = 13/113 (11%) Query: 19 RDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGK 78 D + D TL + I+PV H I + + + S D Sbjct: 4 SDHDELSTDTTLHEEKFRIEPVPVH----------HQLDILKIAVSENYKTFASVGLDRC 53 Query: 79 LIIWDSYTT--NKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTR 129 L++WD V + + A P GNYV+ D I N+++ Sbjct: 54 LVVWDLRQWCTKLVLSKEQMPRTLKAIALDPQGNYVSLFSKD-TLFILNVESP 105 Score = 28.9 bits (63), Expect = 3.6, Method: Composition-based stats. Identities = 10/84 (11%), Positives = 21/84 (25%), Gaps = 3/84 (3%) Query: 125 NLKTREGNVRVSRELAGHT-GYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGH 183 + E R+ H L + + D +WD+ + Sbjct: 12 DTTLHEEKFRIEPVPVHHQLDILKIAVSENYKTFASVGLDRCLVVWDLRQWCTKLVLSKE 71 Query: 184 TGDVM--SLSLAPDTRLFVSGACD 205 +++L P + D Sbjct: 72 QMPRTLKAIALDPQGNYVSLFSKD 95 Score = 28.1 bits (61), Expect = 6.1, Method: Composition-based stats. Identities = 11/65 (16%), Positives = 21/65 (32%), Gaps = 7/65 (10%) Query: 276 VSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSF 335 + +S L D K V H + + V+++ A+ D Sbjct: 1 MGWSDHDEL----STDTTL---HEEKFRIEPVPVHHQLDILKIAVSENYKTFASVGLDRC 53 Query: 336 LKIWN 340 L +W+ Sbjct: 54 LVVWD 58 >1Z68-A nrPDB Length = 719 Score = 43.1 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 26/163 (15%), Positives = 59/163 (36%), Gaps = 28/163 (17%) Query: 151 FLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTG-DVMSLSL--APDTRLFVSGACDAS 207 ++ + + S D L++IETGQ T + T V + + +PD + + + Sbjct: 23 WISGQEYLHQSADNNIVLYNIETGQSYTILSNRTMKSVNASNYGLSPDRQFVYLESDYSK 82 Query: 208 A---------KLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSD----------DA 248 ++D+ G + I +C+ P G+ A D Sbjct: 83 LWRYSYTATYYIYDLSNGEFVRG-NELPRPIQYLCWSPVGSKLAYVYQNNIYLKQRPGDP 141 Query: 249 TCRL-FDLRADQELMTYSH----DNIICGITSVSFSKSGRLLL 286 ++ F+ R ++ + ++ ++ +S +G+ L Sbjct: 142 PFQITFNGRENKIFNGIPDWVYEEEMLATKYALWWSPNGKFLA 184 >5BPW-A nrPDB Length = 843 Score = 42.8 bits (99), Expect = 2e-04, Method: Composition-based stats. Identities = 18/113 (15%), Positives = 38/113 (33%), Gaps = 5/113 (4%) Query: 126 LKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTF---TG 182 T + RV E + + I ++ L + + + +F Sbjct: 4 FPTCFPSFRVVGEKQLPQEIIFLVWSPKRDLIALANTAGEVLLHRLASFHRVWSFPPNEN 63 Query: 183 HTGDVMSLSLAPDTRLFVSGACD-ASAKLWDVREGMCRQTFTGHESDINAICF 234 +V L+ PD +L D L DV + +F+ E+ ++ + + Sbjct: 64 TGKEVTCLAWRPDGKLLAFALADTKKIVLCDVEKPESLHSFSV-EAPVSCMHW 115 Score = 41.2 bits (95), Expect = 6e-04, Method: Composition-based stats. Identities = 16/104 (15%), Positives = 37/104 (35%), Gaps = 4/104 (3%) Query: 190 LSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHES---DINAICFFPNGNAFATGSD 246 L +P L L + +F +E+ ++ + + P+G A Sbjct: 26 LVWSPKRDLIALANTAGEVLLHRLASFHRVWSFPPNENTGKEVTCLAWRPDGKLLAFALA 85 Query: 247 D-ATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGY 289 D L D+ + L ++S + + + + + +L + Y Sbjct: 86 DTKKIVLCDVEKPESLHSFSVEAPVSCMHWMEVTVESSVLTSFY 129 Score = 40.8 bits (94), Expect = 8e-04, Method: Composition-based stats. Identities = 16/96 (16%), Positives = 37/96 (38%), Gaps = 3/96 (3%) Query: 227 SDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYS-HDNIICGITSVSFSKSGRLL 285 +I + + P + A + L L + + ++ ++N +T +++ G+LL Sbjct: 21 QEIIFLVWSPKRDLIALANTAGEVLLHRLASFHRVWSFPPNENTGKEVTCLAWRPDGKLL 80 Query: 286 LAGYDD-FNCNVWDALKADRAGVLAGHDNRVSCLGV 320 D + D K + + + VSC+ Sbjct: 81 AFALADTKKIVLCDVEKPESLHSFSV-EAPVSCMHW 115 Score = 33.1 bits (74), Expect = 0.16, Method: Composition-based stats. Identities = 10/51 (19%), Positives = 22/51 (43%), Gaps = 2/51 (3%) Query: 56 AKIYAMHWGTDSRLLVSASQD-GKLIIWDSYTTNKVHAIPLRSSWVMTCAY 105 ++ + W D +LL A D K+++ D +H+ + + V + Sbjct: 66 KEVTCLAWRPDGKLLAFALADTKKIVLCDVEKPESLHSFSVE-APVSCMHW 115 Score = 32.0 bits (71), Expect = 0.44, Method: Composition-based stats. Identities = 12/73 (16%), Positives = 21/73 (28%), Gaps = 3/73 (4%) Query: 264 YSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDN---RVSCLGV 320 + I + +S L+ + R ++N V+CL Sbjct: 14 VGEKQLPQEIIFLVWSPKRDLIALANTAGEVLLHRLASFHRVWSFPPNENTGKEVTCLAW 73 Query: 321 TDDGMAVATGSWD 333 DG +A D Sbjct: 74 RPDGKLLAFALAD 86 >5BPT-A nrPDB Length = 741 Score = 42.4 bits (98), Expect = 3e-04, Method: Composition-based stats. Identities = 17/104 (16%), Positives = 38/104 (36%), Gaps = 4/104 (3%) Query: 190 LSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHES---DINAICFFPNGNAFATGSD 246 L+ +P L L + + +E+ ++ + + P+G A G Sbjct: 19 LAWSPKRDLIALVNKAGEVLLHRLANIQRVWSLPPNENTGKEVTCLAWRPDGKILAFGLA 78 Query: 247 D-ATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGY 289 D L D+ + L ++S + I + + + +L + Y Sbjct: 79 DTKKVILCDVEKPESLHSFSLETPISCMQWMEVNVENSVLTSFY 122 Score = 41.6 bits (96), Expect = 6e-04, Method: Composition-based stats. Identities = 16/96 (16%), Positives = 37/96 (38%), Gaps = 3/96 (3%) Query: 227 SDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYS-HDNIICGITSVSFSKSGRLL 285 +I + + P + A + L L Q + + ++N +T +++ G++L Sbjct: 14 HEIIFLAWSPKRDLIALVNKAGEVLLHRLANIQRVWSLPPNENTGKEVTCLAWRPDGKIL 73 Query: 286 LAGYDD-FNCNVWDALKADRAGVLAGHDNRVSCLGV 320 G D + D K + + + +SC+ Sbjct: 74 AFGLADTKKVILCDVEKPESLHSFSL-ETPISCMQW 108 Score = 39.3 bits (90), Expect = 0.002, Method: Composition-based stats. Identities = 14/96 (14%), Positives = 32/96 (33%), Gaps = 6/96 (6%) Query: 144 GYLSCCRFLDDNQIVT-SSGDTTCALWDIETGQQTTTF---TGHTGDVMSLSLAPDTRLF 199 + + ++ + L + Q+ + +V L+ PD ++ Sbjct: 14 HEIIFLAWSPKRDLIALVNKAGEVLLHRLANIQRVWSLPPNENTGKEVTCLAWRPDGKIL 73 Query: 200 VSGACD-ASAKLWDVREGMCRQTFTGHESDINAICF 234 G D L DV + +F E+ I+ + + Sbjct: 74 AFGLADTKKVILCDVEKPESLHSF-SLETPISCMQW 108 Score = 34.7 bits (78), Expect = 0.060, Method: Composition-based stats. Identities = 9/51 (17%), Positives = 21/51 (41%), Gaps = 2/51 (3%) Query: 56 AKIYAMHWGTDSRLLVSASQD-GKLIIWDSYTTNKVHAIPLRSSWVMTCAY 105 ++ + W D ++L D K+I+ D +H+ L + + + Sbjct: 59 KEVTCLAWRPDGKILAFGLADTKKVILCDVEKPESLHSFSLETP-ISCMQW 108 Score = 33.9 bits (76), Expect = 0.093, Method: Composition-based stats. Identities = 14/83 (16%), Positives = 22/83 (26%), Gaps = 15/83 (18%) Query: 260 ELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNC---------NVWDALKADRAGVLAG 310 + I +++S L+ VW + G Sbjct: 3 PFRQVGEKQLPHEIIFLAWSPKRDLIALVNKAGEVLLHRLANIQRVWSLPPNENTG---- 58 Query: 311 HDNRVSCLGVTDDGMAVATGSWD 333 V+CL DG +A G D Sbjct: 59 --KEVTCLAWRPDGKILAFGLAD 79 >5WLC-LK nrPDB Length = 575 Score = 42.0 bits (97), Expect = 4e-04, Method: Composition-based stats. Identities = 32/217 (14%), Positives = 59/217 (27%), Gaps = 11/217 (5%) Query: 113 ACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIE 172 A N IY L + V S ++ + + D S L D + Sbjct: 22 ASVAQKNNVDIYPLNETKDYVVNSSLVSHIDYETNDMKVSDVIFFGWCSD-----LIDTQ 76 Query: 173 TGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAI 232 + G S S FV+G D ++ G ++ +I Sbjct: 77 SSNIKRKLDEDEGTGES-SEQRCENFFVNGFPDGRIVVYS-SNGKDIVNIIKNKKEILGA 134 Query: 233 CFFPNGNAFATGSDDATCRLFDLRADQELMTYSH-DNIICGITSVSF-SKSGRLLLAGYD 290 + D + + L T++ D I ++G LL+ Sbjct: 135 DTDESDIWIL--DSDKVVKKLQYNNSKPLKTFTLVDGKDDEIVHFQILHQNGTLLVCIIT 192 Query: 291 DFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAV 327 + D K + + + + DG + Sbjct: 193 KQMVYIVDPSKRRPSTKYSFEISDAVACEFSSDGKYL 229 >6NAU-A nrPDB Length = 334 Score = 41.2 bits (95), Expect = 6e-04, Method: Composition-based stats. Identities = 31/185 (16%), Positives = 56/185 (30%), Gaps = 28/185 (15%) Query: 51 LRG-HLAKI-------YAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMT 102 L G H A I + D L + S DG L + + Sbjct: 129 LEGCHSANISPDNRTLWVPALKQDRICLFTLSDDGFL-----SAQEPAEVTTVEGAGPRH 183 Query: 103 CAYAPSGNYVACGG-LDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRF------LDDN 155 + P+ Y C L++ ++ LK +GN+ + L S R+ D Sbjct: 184 MVFHPNQQYGYCVNELNSSIDVWELKDPKGNIECVQTLDMMPPDFSGVRWAADIHITPDG 243 Query: 156 QIVTSSGDTTCALWDI----ETGQQTTTFTGHTGDVMSLSLAPDTR---LFVSGACDASA 208 + + + D T ++ + E G + D L +G Sbjct: 244 RHLYAC-DRTASIITVFSVSEDGSVLAVEGYQPTETQPRGFNLDHSGKYLIAAGQKSHHI 302 Query: 209 KLWDV 213 ++D+ Sbjct: 303 AVYDI 307 Score = 30.4 bits (67), Expect = 1.0, Method: Composition-based stats. Identities = 16/97 (16%), Positives = 31/97 (31%), Gaps = 5/97 (5%) Query: 241 FATGS-DDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAG-YDDFNCNVWD 298 T S + ++ L AD +L + + + S + L G +F + Sbjct: 8 VYTASPESQQIHVWSLEADGKLTLVQVVDAPGQVQPMVVSPNKEFLYVGVRPEFRVLAYR 67 Query: 299 ALKADRAGVLAGHD---NRVSCLGVTDDGMAVATGSW 332 + A AG + + G V + S+ Sbjct: 68 ITPDNGALTFAGEAALPGSPTHISTDRHGRFVFSASY 104 >5CWW-B nrPDB Length = 595 Score = 37.4 bits (85), Expect = 0.010, Method: Composition-based stats. Identities = 18/92 (19%), Positives = 34/92 (36%), Gaps = 15/92 (16%) Query: 172 ETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASA---KLWDVREGMCRQTFTGHESD 228 T HT + + + PD+ D + K W + + S Sbjct: 124 PNQDFLAVLTSHT---VHICILPDSSHLHI--QDTTPFKPKFWTLGPTTHVTS----RSA 174 Query: 229 INAICFFP---NGNAFATGSDDATCRLFDLRA 257 + + + P NG+A T ++DA R+++L Sbjct: 175 VVSAVWHPLGVNGHALVTVTEDAIVRVWELST 206 Score = 33.9 bits (76), Expect = 0.092, Method: Composition-based stats. Identities = 18/95 (18%), Positives = 31/95 (32%), Gaps = 17/95 (17%) Query: 227 SDINAICFFPNGNAFATGS----------DDATCRLFDLRADQE----LMTYSHDNIICG 272 DI + PN + A + D + + D + L +H Sbjct: 115 DDIRQLVMSPNQDFLAVLTSHTVHICILPDSSHLHIQDTTPFKPKFWTLGPTTHVTSRSA 174 Query: 273 ITSVSFSK---SGRLLLAGYDDFNCNVWDALKADR 304 + S + +G L+ +D VW+ ADR Sbjct: 175 VVSAVWHPLGVNGHALVTVTEDAIVRVWELSTADR 209 Score = 31.2 bits (69), Expect = 0.67, Method: Composition-based stats. Identities = 6/37 (16%), Positives = 17/37 (45%), Gaps = 3/37 (8%) Query: 55 LAKIYAMHWGT---DSRLLVSASQDGKLIIWDSYTTN 88 + + + W + LV+ ++D + +W+ T + Sbjct: 172 RSAVVSAVWHPLGVNGHALVTVTEDAIVRVWELSTAD 208 >6FYY-p nrPDB Length = 763 Score = 37.0 bits (84), Expect = 0.012, Method: Composition-based stats. Identities = 47/356 (13%), Positives = 101/356 (28%), Gaps = 74/356 (20%) Query: 2 SELDQLRQEAEQLKNQIRDARKACADAT--LSQITNNIDPVGRIQMRTRRTLRGHLAKIY 59 S ++ E +N + + T S + G R H + Sbjct: 216 SMFNEEDSLVESRENWSTNYVRFSPKGTYLFSYHQQGVTAWGGPNFDRLRRFY-HPD-VR 273 Query: 60 AMHWGTDSRLLVSAS-------QD------------GKLIIWDSYTTNKVHAIPLRSSWV 100 + + LV+ S +D +L IWD + + P+ S Sbjct: 274 NSSVSPNEKYLVTFSTEPIIVEEDNEFSPFTKKNEGHQLCIWDIASGLLMATFPVIKSPY 333 Query: 101 MT---CAYAPSGNYVACGGLDNIC-------------------SIYNLKTREGNVRVSRE 138 + ++ + Y A D++ I + V++ Sbjct: 334 LKWPLVRWSYNDKYCARMVGDSLIVHDATKNFMPLEAKALKPSGIRDFSFAPEGVKLQPF 393 Query: 139 LAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRL 198 G + + + + T A ++ G+ T ++L Sbjct: 394 RNGDEPSVLLAYWTPETNNSACTA--TIA--EVPRGRVLKTVNLVQVSNVTLHWQNQAEF 449 Query: 199 FV--------SGACD-ASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGS---- 245 SG ++ ++ + E + + + P+GN F T S Sbjct: 450 LCFNVERHTKSGKTQFSNLQICRLTERDIPVEKVELKDSVFEFGWEPHGNRFVTISVHEV 509 Query: 246 DD-------ATCRLF--DLRADQELMT---YSHDNIICGITSVSFSKSGRLLLAGY 289 D T R + + + +++ + +VS+S +GR ++ G Sbjct: 510 ADMNYAIPANTIRFYAPETKEKTDVIKRWSLVKEIPKTFANTVSWSPAGRFVVVGA 565 >4MHC-A nrPDB Length = 826 Score = 35.8 bits (81), Expect = 0.026, Method: Composition-based stats. Identities = 24/137 (17%), Positives = 48/137 (35%), Gaps = 20/137 (14%) Query: 203 ACDASAKLWDVREGMCRQTFTGHESDINAICFF-PNGNAFATGSDDATC--RLFDL---- 255 D LW++ E I + P+ N F + ++ LFD+ Sbjct: 108 TSDNKLILWNINNSSEYHCIDEIEHTILKVKLVKPSPNTFVSSVENLLIVATLFDIYILT 167 Query: 256 ----RADQELMTYSHDNIICGITS------VSFSKSGRLLLAGYDDFNCNVWDALKADRA 305 EL + + + +T +S+ ++G++ G D NVW+ Sbjct: 168 ISFNDRTHELNIF-NTGLKVNVTGFNVSNIISYERTGQIFFTGATDG-VNVWELQYNCSE 225 Query: 306 GVLAGHDNRVSCLGVTD 322 + N++ CL ++ Sbjct: 226 NLFNSKSNKI-CLTKSN 241 >5LJ5-t nrPDB Length = 503 Score = 35.4 bits (80), Expect = 0.034, Method: Composition-based stats. Identities = 23/140 (16%), Positives = 42/140 (30%), Gaps = 23/140 (16%) Query: 101 MTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTS 160 + +A D I +YNL + + SR + +F D+ + Sbjct: 334 SSGVLHKDSLLLALYSPDGILDVYNLSSPDQAS--SRFPVDEEAKIKEVKFADNGYWMVV 391 Query: 161 SGDTTCALWDIETGQQTTTF--------TGHTGDV---------MSLSLAPDTRLFVSGA 203 D T +D+ + T TG V ++ + ++ Sbjct: 392 ECDQTVVCFDLR--KDVGTLAYPTYTIPEFKTGTVTYDIDDSGKNMIAYSNESNSLTIYK 449 Query: 204 CDASAKLW--DVREGMCRQT 221 D K W D +C Q+ Sbjct: 450 FDKKTKNWTKDEESALCLQS 469 Score = 30.4 bits (67), Expect = 1.2, Method: Composition-based stats. Identities = 18/147 (12%), Positives = 47/147 (31%), Gaps = 12/147 (8%) Query: 157 IVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASA--KLWDVR 214 I+ S + ++++ + GH +V T F+ + + ++ Sbjct: 268 ILDSKTNKVLREIEVDSANEIIYMYGH-NEVN-------TEYFIWADNRGTIGFQSYEDD 319 Query: 215 EGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGIT 274 + + + + A S D +++L + + + + I Sbjct: 320 SQYIVHSAKSDVEYSSGV-LHKDSLLLALYSPDGILDVYNLSSPDQASSRFPVDEEAKIK 378 Query: 275 SVSFSKSGRLLLAGYDDFNCNVWDALK 301 V F+ +G ++ D +D K Sbjct: 379 EVKFADNGYWMVV-ECDQTVVCFDLRK 404 >1K3I-A nrPDB Length = 656 Score = 35.4 bits (80), Expect = 0.034, Method: Composition-based stats. Identities = 17/73 (23%), Positives = 26/73 (35%), Gaps = 11/73 (15%) Query: 152 LDDNQIVTSSGDTTCALWDIETG---QQTTTFTGHTGDVMSLSLAPDTRLFVSGACD-AS 207 +TSS WD TG +T T T H +S+ + ++ V+G D Sbjct: 214 SPGGITLTSS-------WDPSTGIVSDRTVTVTKHDMFCPGISMDGNGQIVVTGGNDAKK 266 Query: 208 AKLWDVREGMCRQ 220 L+D Sbjct: 267 TSLYDSSSDSWIP 279 >1MG2-A nrPDB Length = 390 Score = 35.4 bits (80), Expect = 0.037, Method: Composition-based stats. Identities = 16/76 (21%), Positives = 34/76 (44%), Gaps = 9/76 (11%) Query: 159 TSSGDTTCALWDIETGQQTTTFT-GHTGDVMSLSLAPDTR--LFVSGACDASAKLWDVRE 215 T+S + D +TG++ F GH ++ S++++ D + L+ D + + D Sbjct: 312 TAS--RFVVVLDAKTGERLAKFEMGH--EIDSINVSQDEKPLLYALSTGDKTLYIHDAES 367 Query: 216 GMCRQTFT--GHESDI 229 G ++ GH + Sbjct: 368 GEELRSVNQLGHGPQV 383 Score = 29.3 bits (64), Expect = 2.3, Method: Composition-based stats. Identities = 16/72 (22%), Positives = 30/72 (41%), Gaps = 6/72 (8%) Query: 119 NICSIYNLKTREGNVRVSRELAGHT-GYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQT 177 + + KT E R+++ GH ++ + S+GD T + D E+G++ Sbjct: 315 RFVVVLDAKTGE---RLAKFEMGHEIDSINVSQDEKPLLYALSTGDKTLYIHDAESGEEL 371 Query: 178 TTFT--GHTGDV 187 + GH V Sbjct: 372 RSVNQLGHGPQV 383 >2J04-A nrPDB Length = 588 Score = 35.4 bits (80), Expect = 0.040, Method: Composition-based stats. Identities = 13/116 (11%), Positives = 39/116 (33%), Gaps = 13/116 (11%) Query: 190 LSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDIN--AICFFPNGNAFATGSDD 247 +P + + + ++ + + G+ S + P ++ G++D Sbjct: 91 CKPSPIDDWMAVLSNNGNVSVFKDNKMLTNLDSKGNLSSRTYHCFEWNPIESSIVVGNED 150 Query: 248 ATCRLFDLRADQEL---------MTYSHDNIICGITSVSFSKSGRLLLAGYDDFNC 294 + F +R + E + S +T + + + +L+A + + Sbjct: 151 GELQFFSIRKNSENTPEFYFESSIRLSDAGSKDWVTHIVWYED--VLVAALSNNSV 204 Score = 28.9 bits (63), Expect = 3.2, Method: Composition-based stats. Identities = 11/119 (9%), Positives = 27/119 (22%), Gaps = 13/119 (10%) Query: 55 LAKIYAMHWGTDSRLLVSASQDGKLIIWDS---YTTNKVHAIP--------LRSSWVMTC 103 + W +V ++DG+L + WV Sbjct: 129 SRTYHCFEWNPIESSIVVGNEDGELQFFSIRKNSENTPEFYFESSIRLSDAGSKDWVTHI 188 Query: 104 AYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSG 162 + + +N + ++ + +D ++T G Sbjct: 189 VWYED--VLVAALSNNSVFSMTVSASSHQPVSRMIQNASRRKITDLKIVDYKVVLTCPG 245 >3WJ9-A nrPDB Length = 412 Score = 35.0 bits (79), Expect = 0.047, Method: Composition-based stats. Identities = 21/119 (17%), Positives = 38/119 (31%), Gaps = 17/119 (14%) Query: 92 AIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRF 151 S Y+P+G A + + E ++++ A +T L F Sbjct: 29 KFEAISEPARNACYSPNGKLFAYATATQVV----INDTESGAKLTQLPAANTYELG---F 81 Query: 152 LDDNQIVTS------SGDTT----CALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFV 200 + +++ D T +W+ ETGQ +F +L D L Sbjct: 82 SPLGKYLSTWERPGKEADGTPKQNMKVWNTETGQLVFSFVQRNQTGWNLQYTCDESLAA 140 >4ZB4-A nrPDB Length = 360 Score = 35.0 bits (79), Expect = 0.052, Method: Composition-based stats. Identities = 23/140 (16%), Positives = 42/140 (30%), Gaps = 23/140 (16%) Query: 101 MTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTS 160 + +A D I +YNL + + SR + +F D+ + Sbjct: 191 SSGVLHKDSLLLALYSPDGILDVYNLSSPDQAS--SRFPVDEEAKIKEVKFADNGYWMVV 248 Query: 161 SGDTTCALWDIETGQQTTTF--------TGHTGDV---------MSLSLAPDTRLFVSGA 203 D T +D+ + T TG V ++ + ++ Sbjct: 249 ECDQTVVCFDLR--KDVGTLAYPTYTIPEFKTGTVTYDIDDSGKNMIAYSNESNSLTIYK 306 Query: 204 CDASAKLW--DVREGMCRQT 221 D K W D +C Q+ Sbjct: 307 FDKKTKNWTKDEESALCLQS 326 Score = 29.7 bits (65), Expect = 1.8, Method: Composition-based stats. Identities = 18/147 (12%), Positives = 47/147 (31%), Gaps = 12/147 (8%) Query: 157 IVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASA--KLWDVR 214 I+ S + ++++ + GH +V T F+ + + ++ Sbjct: 125 ILDSKTNKVLREIEVDSANEIIYMYGH-NEVN-------TEYFIWADNRGTIGFQSYEDD 176 Query: 215 EGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGIT 274 + + + + A S D +++L + + + + I Sbjct: 177 SQYIVHSAKSDVEYSSGV-LHKDSLLLALYSPDGILDVYNLSSPDQASSRFPVDEEAKIK 235 Query: 275 SVSFSKSGRLLLAGYDDFNCNVWDALK 301 V F+ +G ++ D +D K Sbjct: 236 EVKFADNGYWMVV-ECDQTVVCFDLRK 261 >4U1F-A nrPDB Length = 497 Score = 34.7 bits (78), Expect = 0.067, Method: Composition-based stats. Identities = 47/356 (13%), Positives = 101/356 (28%), Gaps = 74/356 (20%) Query: 2 SELDQLRQEAEQLKNQIRDARKACADAT--LSQITNNIDPVGRIQMRTRRTLRGHLAKIY 59 S ++ E +N + + T S + G R H + Sbjct: 48 SMFNEEDSLVESRENWSTNYVRFSPKGTYLFSYHQQGVTAWGGPNFDRLRRFY-HPD-VR 105 Query: 60 AMHWGTDSRLLVSAS-------QD------------GKLIIWDSYTTNKVHAIPLRSSWV 100 + + LV+ S +D +L IWD + + P+ S Sbjct: 106 NSSVSPNEKYLVTFSTEPIIVEEDNEFSPFTKKNEGHQLCIWDIASGLLMATFPVIKSPY 165 Query: 101 MT---CAYAPSGNYVACGGLDNIC-------------------SIYNLKTREGNVRVSRE 138 + ++ + Y A D++ I + V++ Sbjct: 166 LKWPLVRWSYNDKYCARMVGDSLIVHDATKNFMPLEAKALKPSGIRDFSFAPEGVKLQPF 225 Query: 139 LAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRL 198 G + + + + T A ++ G+ T ++L Sbjct: 226 RNGDEPSVLLAYWTPETNNSACTA--TIA--EVPRGRVLKTVNLVQVSNVTLHWQNQAEF 281 Query: 199 FV--------SGACD-ASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGS---- 245 SG ++ ++ + E + + + P+GN F T S Sbjct: 282 LCFNVERHTKSGKTQFSNLQICRLTERDIPVEKVELKDSVFEFGWEPHGNRFVTISVHEV 341 Query: 246 DD-------ATCRLF--DLRADQELMT---YSHDNIICGITSVSFSKSGRLLLAGY 289 D T R + + + +++ + +VS+S +GR ++ G Sbjct: 342 ADMNYAIPANTIRFYAPETKEKTDVIKRWSLVKEIPKTFANTVSWSPAGRFVVVGA 397 >6IGR-A nrPDB Length = 656 Score = 34.3 bits (77), Expect = 0.073, Method: Composition-based stats. Identities = 34/265 (12%), Positives = 74/265 (27%), Gaps = 49/265 (18%) Query: 55 LAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVAC 114 + W D R + + D +V P+ + + P Sbjct: 123 KNGVSGPQWSPDGRFIAFTTTADTEDKRDERGEARVLTRPVYRA--NGADWLPE------ 174 Query: 115 GGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQ--IVTSSGDTTCA----- 167 +Y+++ + RE + + D++ ++ S D A Sbjct: 175 --RPAALWLYDVEADK-----LREWYAPEIGIGALSWWPDSRGVLIVQSEDEWQASQWRQ 227 Query: 168 -LWDIE-----TGQQTTTFTGHTGDVMSLSLAPDTRLFVS----GACDAS--AKLWDVRE 215 ++D+ L+ PD + F + A L+ + Sbjct: 228 DVYDLPLPTADAPAAPQKLLDWNSAAHGLAPHPDGQRFALIGRPAGKGNTEHAHLYLIEN 287 Query: 216 GMCRQTFTGHESDINAIC--------------FFPNGNAFATGSDDATCRLFDLRADQEL 261 G R+ TGH+ + + + + + LF + Sbjct: 288 GQHRRLDTGHDHPVGDAVGGDCHVGAFPEGPRWLDGDTLLFSSTVRGSVGLFTAHIGGGV 347 Query: 262 MTYSHDNIICGITSVSFSKSGRLLL 286 Y HD I++ + ++ G L+ Sbjct: 348 KAYDHDPQGV-ISAFTANEHGVALI 371 >2EEP-A nrPDB Length = 706 Score = 33.5 bits (75), Expect = 0.12, Method: Composition-based stats. Identities = 10/65 (15%), Positives = 23/65 (35%), Gaps = 5/65 (7%) Query: 249 TCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDF-----NCNVWDALKAD 303 T ++ L + + + + +T++S+S +L + N +DA Sbjct: 236 TVGIYHLATGKTVYLQTGEPKEKFLTNLSWSPDENILYVAEVNRAQNECKVNAYDAETGR 295 Query: 304 RAGVL 308 L Sbjct: 296 FVRTL 300 >2QT9-A nrPDB Length = 766 Score = 33.1 bits (74), Expect = 0.16, Method: Composition-based stats. Identities = 21/117 (17%), Positives = 33/117 (28%), Gaps = 27/117 (23%) Query: 188 MSLSLAPDTRLFVSGACDASAKLWDVREGM-----CRQTFTGHESDINAICFFPNGNAFA 242 SL D + + +++ G TF IN P+G Sbjct: 58 YSLRWISDHEYLY--KQENNILVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFIL 115 Query: 243 -------------TGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLL 286 T S D ++DL Q + + I V++S G L Sbjct: 116 LEYNYVKQWRHSYTASYD----IYDLNKRQ---LITEERIPNNTQWVTWSPVGHKLA 165 Score = 30.8 bits (68), Expect = 0.94, Method: Composition-based stats. Identities = 24/218 (11%), Positives = 65/218 (29%), Gaps = 54/218 (24%) Query: 101 MTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELA---GHTGYLSCCRFLDDNQI 157 + + Y+ +N ++N + +V + GH+ ++ D Q Sbjct: 58 YSLRWISDHEYLY--KQENNILVFNAEYGNSSVFLENSTFDEFGHS--INDYSISPDGQF 113 Query: 158 V--------------TSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGA 203 + T+S D ++D+ +Q T + ++ +P Sbjct: 114 ILLEYNYVKQWRHSYTASYD----IYDL-NKRQLITEERIPNNTQWVTWSPVGHKLA--- 165 Query: 204 CDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMT 263 +W+ + I + + G D +++ Sbjct: 166 -----YVWN---NDIYVKIEPNL-PSYRITWTGKEDIIYNGITD---WVYE--------- 204 Query: 264 YSHDNIICGITSVSFSKSGRLLL-AGYDDFNCNVWDAL 300 + + +++ +S +G L A ++D + + Sbjct: 205 ---EEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYS 239 >5OLJ-A nrPDB Length = 723 Score = 32.7 bits (73), Expect = 0.22, Method: Composition-based stats. Identities = 21/103 (20%), Positives = 34/103 (33%), Gaps = 20/103 (19%) Query: 123 IYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCAL----WDIE-----T 173 +Y+ R + + L+ H G + F D ++V D + +D E Sbjct: 122 VYDYDVR---RNLVKPLSEHVGKVMIPTFSPDGRMVAFVRDNNIFIKKFDFDTEVQVTTD 178 Query: 174 GQQTTTFTGHTGDVMS--------LSLAPDTRLFVSGACDASA 208 GQ + G T V +S + D D SA Sbjct: 179 GQINSVLNGATDWVYEEEFGVTNLMSWSADNAFLAFVRSDESA 221 Score = 30.8 bits (68), Expect = 0.77, Method: Composition-based stats. Identities = 12/54 (22%), Positives = 23/54 (42%), Gaps = 2/54 (3%) Query: 211 WDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDAT-CRLFDLRADQELMT 263 +DVR + + + H + F P+G A D+ + FD + ++ T Sbjct: 125 YDVRRNL-VKPLSEHVGKVMIPTFSPDGRMVAFVRDNNIFIKKFDFDTEVQVTT 177 Score = 28.1 bits (61), Expect = 5.9, Method: Composition-based stats. Identities = 9/34 (26%), Positives = 16/34 (47%), Gaps = 1/34 (2%) Query: 296 VWDA-LKADRAGVLAGHDNRVSCLGVTDDGMAVA 328 V+D ++ + L+ H +V + DG VA Sbjct: 122 VYDYDVRRNLVKPLSEHVGKVMIPTFSPDGRMVA 155 >5HAX-A nrPDB Length = 742 Score = 32.7 bits (73), Expect = 0.26, Method: Composition-based stats. Identities = 29/230 (12%), Positives = 62/230 (26%), Gaps = 42/230 (18%) Query: 73 ASQDGKLIIWDSYTTNK-VHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLK---- 127 AS D L +WD N + + + A P V + ++ + Sbjct: 86 ASIDSSLFLWDYTHPNPELIGYEEATHTITAVALVPPKPGVFVKTITHVLVVATTSEIIL 145 Query: 128 ---TREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHT 184 + S+ L ++ +S R D + + D G + Sbjct: 146 LGVSATPTPSGSKSLTLYSTRMSVHRGGSDVSFIVGTKDGRI------------FLGGES 193 Query: 185 G-DVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGH------ESDINAICFFPN 237 D+ + + R F S C + H + + + Sbjct: 194 DTDIHEIFYQQEERWFSS---------------RCGKINHSHPFGSRQQEWLRGLYVDDT 238 Query: 238 GNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLA 287 N + S+ +T R + + ++L + + + L Sbjct: 239 RNLLYSLSNRSTIRTYHMEGPEKLTKVIEKDKTSCLRDFAHMADSSPLFT 288 >6GC1-A nrPDB Length = 579 Score = 32.0 bits (71), Expect = 0.34, Method: Composition-based stats. Identities = 23/132 (17%), Positives = 45/132 (34%), Gaps = 26/132 (19%) Query: 193 APDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRL 252 P + LFV+ + ++ + +++G + G +N FA G D Sbjct: 428 DPWSCLFVADSESSTVRTVSLKDGAVKHLVGGERDPMN---------LFAFGDVDG---- 474 Query: 253 FDLRADQELMTYSHDNIICGITSVSFSKSGRLL-LAGYDDFNCNVWDALKADRAGVL-AG 310 + + +L V++ K LL +A + V D + + G Sbjct: 475 --VGINAKLQ---------HPLGVTWDKKRNLLYVADSYNHKIKVVDPKTKNCTTLAGTG 523 Query: 311 HDNRVSCLGVTD 322 N V+ T+ Sbjct: 524 DTNNVTSSSFTE 535 >5SUM-A nrPDB Length = 468 Score = 31.2 bits (69), Expect = 0.62, Method: Composition-based stats. Identities = 7/28 (25%), Positives = 14/28 (50%) Query: 237 NGNAFATGSDDATCRLFDLRADQELMTY 264 +G G D R+FD++ ++ L+ Sbjct: 376 DGKYLLQGGLDRYVRIFDIKTNKMLVKV 403 Score = 30.0 bits (66), Expect = 1.3, Method: Composition-based stats. Identities = 13/65 (20%), Positives = 19/65 (29%), Gaps = 2/65 (3%) Query: 241 FATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDAL 300 T FD + L D+I T + G+ LL G D ++D Sbjct: 338 VITTDYKKNVFKFD-GNGRMLGKVGRDDITGSSTYIHVH-DGKYLLQGGLDRYVRIFDIK 395 Query: 301 KADRA 305 Sbjct: 396 TNKML 400 Score = 28.1 bits (61), Expect = 5.4, Method: Composition-based stats. Identities = 6/24 (25%), Positives = 10/24 (41%) Query: 65 TDSRLLVSASQDGKLIIWDSYTTN 88 D + L+ D + I+D T Sbjct: 375 HDGKYLLQGGLDRYVRIFDIKTNK 398 >5L8S-A nrPDB Length = 604 Score = 30.8 bits (68), Expect = 0.84, Method: Composition-based stats. Identities = 18/122 (14%), Positives = 36/122 (29%), Gaps = 6/122 (4%) Query: 171 IETGQQTTTFTGHTGDVMSLSLAPDT-RLFVSGACDASAKLWDVREGMCRQTFTGHESD- 228 I + T T + + +++ D RL + + LW + H + Sbjct: 2 INFPKPTVEQFFRTYTITNFAVSSDEKRLVFNANLNGKMNLWAMDLPDTYPYLFAHRDES 61 Query: 229 INAICFFPNGNAFATG---SDDATCRLFDLRADQEL-MTYSHDNIICGITSVSFSKSGRL 284 N I F P G D +++ + + L + S G+ Sbjct: 62 CNFIKFDPENRYVLAGFDKDGDENYQIYAIPNEGGLPHPLITGDASEKYYFSHLSADGKC 121 Query: 285 LL 286 + Sbjct: 122 VY 123 >2GVU-A nrPDB Length = 314 Score = 30.0 bits (66), Expect = 1.3, Method: Composition-based stats. Identities = 12/98 (12%), Positives = 24/98 (24%), Gaps = 10/98 (10%) Query: 54 HLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVA 113 H M + D+ LLV+ + ++ I + P + Sbjct: 224 HEGGANGMDFDEDNNLLVANWGSSHIEVFGPDGGQPKMRIRCPFEKPSNLHFKPQTKTIF 283 Query: 114 CGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRF 151 +N + + G Y +F Sbjct: 284 VTEHEN----------NAVWKFEWQRNGKKQYCETLKF 311 >6AHV-A nrPDB Length = 363 Score = 29.7 bits (65), Expect = 2.1, Method: Composition-based stats. Identities = 9/36 (25%), Positives = 16/36 (44%), Gaps = 1/36 (2%) Query: 213 VREGMCRQ-TFTGHESDINAICFFPNGNAFATGSDD 247 +++G C T+ H + N + PNG + D Sbjct: 87 IKKGSCYALTYNTHIDEDNTVALLPNGKLILSLDKD 122 >4BP8-A nrPDB Length = 715 Score = 29.3 bits (64), Expect = 2.5, Method: Composition-based stats. Identities = 33/241 (13%), Positives = 62/241 (25%), Gaps = 62/241 (25%) Query: 58 IYAMHWGTDSRLLVSASQDGK------LIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNY 111 + + LV+ S D + +KV + + P+ Sbjct: 149 VGCVAPAPPEHALVAYSVDYCGDEVYSIRFVRDVVADKVEGTNG------SVVWGPNAEC 202 Query: 112 VACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTS----SGDTTCA 167 D + + +V R + G C + DD+ + + SGD Sbjct: 203 FFYITKD---------ASKRDNKVWRHIIGQPQSEDVCLYTDDDPLFSVGVGRSGDGKTL 253 Query: 168 LW-------------DIETGQQTTTFTG----HTGDVMSLSLAPDTRLFVSGACDASAKL 210 + D+ G + T G ++ + L V D Sbjct: 254 IICSMSSETSESHLLDLRKGVKHNTLEMVRPREKGVRYTVEMHGTDTLIVLTNKDKCV-- 311 Query: 211 WDVREGMCRQT-----------FTGHESDIN--AICFFPNGNAFATGSDDATCRLFDLRA 257 G T H+ + + F A +G D R++ +R Sbjct: 312 ----NGKVVLTKRSAPTDWGTVLIPHDDKVTIDDVAVFA-KFAVLSGRRDGLTRVWTVRL 366 Query: 258 D 258 Sbjct: 367 G 367 >1D0M-A nrPDB Length = 322 Score = 28.9 bits (63), Expect = 3.0, Method: Composition-based stats. Identities = 13/88 (14%), Positives = 24/88 (27%), Gaps = 3/88 (3%) Query: 227 SDINAICFF-PNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLL 285 + + F P + +G + + D L G S + Sbjct: 137 DALATLSFNYPRRAEYFSGELETFLLMARDEQDDPLNLKGSFAGAMGYGQFMPSSYKQYA 196 Query: 286 LAGYDDFNCNVWDALK--ADRAGVLAGH 311 + D + N+WD + A H Sbjct: 197 VDFSGDGHINLWDPVDAIGSVANYFKAH 224 >3MWP-A nrPDB Length = 577 Score = 28.9 bits (63), Expect = 3.3, Method: Composition-based stats. Identities = 7/46 (15%), Positives = 11/46 (23%) Query: 195 DTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNA 240 D ++WDV+ G + C G Sbjct: 156 GGNQGARAGRDGVVRVWDVKNAELLNNQFGTMPSLTLACLTKQGQV 201 >5JN2-A nrPDB Length = 525 Score = 28.9 bits (63), Expect = 3.4, Method: Composition-based stats. Identities = 19/92 (20%), Positives = 31/92 (33%), Gaps = 2/92 (2%) Query: 35 NNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIP 94 + +D I+ H KI ++ LL S S+D + I D + A Sbjct: 165 SEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASK 224 Query: 95 LRSSWVMTCAYAPSGNYVACGGLDNICSIYNL 126 + T Y V G D C +++ Sbjct: 225 KMKDKIGTAYYI--APEVLHGTYDEKCDVWST 254 >3MA6-A nrPDB Length = 298 Score = 28.9 bits (63), Expect = 3.4, Method: Composition-based stats. Identities = 19/92 (20%), Positives = 31/92 (33%), Gaps = 2/92 (2%) Query: 35 NNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIP 94 + +D I+ H KI ++ LL S S+D + I D + A Sbjct: 130 SEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASK 189 Query: 95 LRSSWVMTCAYAPSGNYVACGGLDNICSIYNL 126 + T Y V G D C +++ Sbjct: 190 KMKDKIGTAYYI--APEVLHGTYDEKCDVWST 219 >4Z25-A nrPDB Length = 652 Score = 28.5 bits (62), Expect = 4.4, Method: Composition-based stats. Identities = 14/77 (18%), Positives = 24/77 (31%), Gaps = 4/77 (5%) Query: 170 DIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDI 229 D G++ + D+ S + + T +D+ Sbjct: 551 DTPAGREFADTLSKLSYYPRVGAHLDSHQGCSCSIGRTV----DSNLKVIGTQNVRVADL 606 Query: 230 NAICFFPNGNAFATGSD 246 +A F P GN +AT S Sbjct: 607 SAAAFPPGGNTWATASM 623 >1RI6-A nrPDB Length = 343 Score = 28.5 bits (62), Expect = 4.4, Method: Composition-based stats. Identities = 14/98 (14%), Positives = 30/98 (30%), Gaps = 4/98 (4%) Query: 239 NAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAG-YDDFNCNVW 297 + + +++L + L ++ + + S R L G +F + Sbjct: 6 TVYIASPESQQIHVWNLNHEGALTLTQVVDVPGQVQPMVVSPDKRYLYVGVRPEFRVLAY 65 Query: 298 DALKADRAGVLAGHD---NRVSCLGVTDDGMAVATGSW 332 D A A ++ + G V GS+ Sbjct: 66 RIAPDDGALTFAAESALPGSLTHISTDHQGQFVFVGSY 103 >6FTI-5 nrPDB Length = 705 Score = 28.1 bits (61), Expect = 5.2, Method: Composition-based stats. Identities = 14/77 (18%), Positives = 28/77 (36%), Gaps = 4/77 (5%) Query: 92 AIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRF 151 S+WV + AY+ ++ G D I++ RE + +S + Sbjct: 470 TYTFHSTWVTSEAYSSPSIVLSARGGDGSRIIFD-DFREAYYWLRHNTPEDAKVMS---W 525 Query: 152 LDDNQIVTSSGDTTCAL 168 D +T+ + T + Sbjct: 526 WDYGYQITAMANRTILV 542 >3R3L-A nrPDB Length = 582 Score = 28.1 bits (61), Expect = 5.7, Method: Composition-based stats. Identities = 7/39 (17%), Positives = 11/39 (28%) Query: 202 GACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNA 240 D ++WDV+ G + C G Sbjct: 155 AGRDGVVRVWDVKNAELLNNQFGTMPSLTLACLTKQGQV 193 >1DBI-A nrPDB Length = 280 Score = 28.1 bits (61), Expect = 5.8, Method: Composition-based stats. Identities = 12/98 (12%), Positives = 33/98 (33%), Gaps = 3/98 (3%) Query: 233 CFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSV---SFSKSGRLLLAGY 289 NG+ + DA D A+ ++ D + + +++K ++ A Sbjct: 104 ALDRNGSGTLSDIADAIIYAADSGAEVINLSLGCDCHTTTLENAVNYAWNKGSVVVAAAG 163 Query: 290 DDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAV 327 ++ + ++ + + D ++ G V Sbjct: 164 NNGSSTTFEPASYENVIAVGAVDQYDRLASFSNYGTWV 201 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.308 0.133 0.359 Lambda K H 0.267 0.0405 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 12,411,160 Number of Sequences: 36641 Number of extensions: 459729 Number of successful extensions: 6747 Number of sequences better than 10.0: 182 Number of HSP's better than 10.0 without gapping: 249 Number of HSP's successfully gapped in prelim test: 76 Number of HSP's that attempted gapping in prelim test: 1235 Number of HSP's gapped (non-prelim): 1551 length of query: 340 length of database: 10,336,785 effective HSP length: 98 effective length of query: 242 effective length of database: 6,745,967 effective search space: 1632524014 effective search space used: 1632524014 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.1 bits) S2: 59 (27.4 bits)